tbuckley/cabot-search huggingface dataset:
AB0155 Microrna-155 Mediates Augmented Cd40 Expression in Lupus Plasmacytoid Dendritic Cells
Authors: Y. Sheng, A.L.Y. Yim, R.C.Y. Tam, A. Chan, L. Lu, C.S. Lau, V.S.F. Chan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic multi-organ autoimmune disease characterized by hyperactivated immune responses to self and persistent systemic inflammation. In addition to autoreactive T and B cells, dendritic cells also play an important role in inducing inflammation. Previously, we have reported abnormalities in circulating and bone marrow (BM)-derived plasmacytoid dendritic cells (pDCs) from SLE patients which suggested that pDCs may play a role in mediating SLE pathogenesis<sup>1–3</sup>. <h3>Objectives</h3> In this investigation, we aim to seek for potential regulators that mediate functional aberrations of pDCs in SLE. <h3>Methods</h3> Bone marrow-derived pDCs from NZB/W F1 mice before and after the disease onset were compared for costimulatory molecule expressions and toll-like receptor (TLR) 7 stimulated responses. TLR7-induced microRNA (miRNA) profile changes in pDCs were examined to identify specific miRNA regulator. Functional validation of specific miRNA was further studied by transfection of miRNA mimics. <h3>Results</h3> <i>In vitro</i> derivation of pDCs from BM of pre-symptomatic and symptomatic NZB/W F1 mice showed similar basal expression of co-stimulatory molecules and TLRs -7 and -9. Functionally, symptomatic pDCs exhibited hypersensitivity to TLR7 but not TLR9 stimulation, as represented by the elevated upregulation of CD40, CD86 and MHC class II molecules upon R837 stimulation. In miRNA profiling, a significantly higher induction of miR-155 in symptomatic pDCs following TLR7 stimulation was observed. The transfection of miR-155 mimics in pre-symptomatic pDCs induced an augmented expression of <i>Cd40</i> which is consistent with the increased CD40 expression in symptomatic pDCs. <i>Cd40</i> expression was also found to negatively correlate with the miR-155 target <i>Ship1</i> in pDCs. <h3>Conclusions</h3> Overall, results from the current study provide evidence for miR-155-mediated regulation in pDC functional abnormalities in SLE. Findings from this study contribute to a better understanding of SLE pathogenesis and ignite future interests in evaluating the molecular regulation in autoimmunity. <h3>References</h3> Jin, O., et al., Systemic lupus erythematosus patients have increased number of circulating plasmacytoid dendritic cells, but decreased myeloid dendritic cells with deficient CD83 expression. Lupus. 2008;17(7):654–62 Jin, O., et al., Abnormalities in circulating plasmacytoid dendritic cells in patients with systemic lupus erythematosus. Arthritis research &amp; therapy. 2010;12(4):R137 Nie, Y.J., et al, Phenotypic and functional abnormalities of bone marrow-derived dendritic cells in systemic lupus erythematosus. Arthritis research &amp; therapy. 2010;12(3):R91. <h3>Acknowledgement</h3> Hong Kong Research Grant Council General Research Fund (770213) <h3>Disclosure of Interest</h3> None declared
Final Results of a Prospective, Non-Interventional Study on Bortezomib (Velcade®, VEL) in the Treatment of Multiple Myeloma (MM) in Office-Based Hematology Units (OBH).
Authors: Wolfgang Ulrich Knauf, Burkhard Otremba, Friedrich Overkamp, Susanne Bammer, Ralf Angermund
Journal: Blood (2006)
Matched Pair Analysis Comparing the Outcomes of Primary Breast and Nodal Diffuse Large B Cell Lymphoma In Patients Treated with R-Chop; Consortium for Improving Survival of Lymphoma (CISL) Study.
Authors: Ho-Young Yhim, Jae-Yong Kwak, Hye Jin Kang, Seok Jin Kim, Won Seog Kim, Jin Seok Kim, Chul Won Choi, Hyeon Seok Eom, Jeong-A Kim, Jae Hoon Lee, Jong Ho Won, Hyeok Shim, Dae Ho Lee, Cheolwon Suh
Journal: Blood (2010)
Serum Interleukin-18 Level Determines Clinical Outcome in Patients with Diffuse Large B-Cell Lymphoma in Rituximab Era.
Authors: Naoe Goto, Hisashi Tsurumi, Senji Kasahara, Takeshi Hara, Nobuhiro Kanemura, Takeshi Yoshikawa, Soranobu Ninomiya, Kengo Ogawa, Toshiki Yamada, Michio Sawada, Tsuyoshi Takami, Hisataka Moriwaki
Journal: Blood (2009)
S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer
Authors: Thamir M. Ismail, Daimark Bennett, Angela M. Platt-Higgins, Morteta Al-Medhity, Roger Barraclough, Philip S. Rudland
Journal: Cancer Research (2016)

Abstract Many human glandular cancers metastasize along nerve tracts, but the mechanisms involved are generally poorly understood. The calcium-binding protein S100A4 is expressed at elevated levels in human cancers, where it has been linked to increased invasion and metastasis. Here we report genetic studies in a Drosophila model to define S100A4 effector functions that mediate metastatic dissemination of mutant Ras-induced tumors in the developing nervous system. In flies overexpressing mutant RasVal12 and S100A4, there was a significant increase in activation of the stress kinase JNK and production of the matrix metalloproteinase MMP1. Genetic or chemical blockades of JNK and MMP1 suppressed metastatic dissemination associated with S100A4 elevation, defining required signaling pathway(s) for S100A4 in this setting. In clinical specimens of human breast cancer, elevated levels of the mammalian paralogs MMP2, MMP9, and MMP13 are associated with a 4- to 9-fold relative decrease in patient survival. In individual tumors, levels of MMP2 and MMP13 correlated more closely with levels of S100A4, whereas MMP9 levels correlated more closely with the S100 family member S100P. Overall, our results suggest the existence of evolutionarily conserved pathways used by S100A4 to promote metastatic dissemination, with potential prognostic and therapeutic implications for metastasis by cancers that preferentially exploit nerve tract migration routes. Cancer Res; 77(3); 780–9. ©2016 AACR.
Prognostic Significance of NQO1 Polymorphism and GST-M1 Deletion in De Novo Acute Myeloid Leukemia
Authors: Yeo-Kyeoung Kim, Hee-Je Kim, Woo-Sung Min, Jong- Ho Won, Deog-Yeon Jo, Moo-Rim Park, Hee-Nam Kim, Il-Kwon Lee, Jae-Sook Ahn, Deok-Hwan Yang, Je-Jung Lee, Hyeoung-Joon Kim
Journal: Blood (2008)
Results of a Phase I Study of Vorinostat In Combination with Pegylated Liposomal Doxorubicin and Bortezomib In Patients with Relapsed/Refractory Multiple Myeloma
Authors: Peter M Voorhees, Cristina Gasparetto, Keren Osman, Kristy Richards, Madlyn Ferraro, Reynaldo Garcia, Jennifer MacLean, Diane Winans, Dominic Moore, John Strader, Robert Z. Orlowski, David Duane Hurd
Journal: Blood (2010)
Safety and Efficacy Profile of rAHF-PFM for Immune Tolerance Induction as Assessed In 3 Clinical Trials (PUP ITI, PRE-PAIR, and PAIR).
Authors: Gerald Spotts, Brigitt E. Abbuehl, Huong D. Luu, Clara K. Song, Jacqueline A. Dyck-Jones, Norma Guzman-Becerra, LieLing Wu, MyungShin Oh, Michael Zoerer, Judith Jill V. Sosa, Darby E. Stephens, Linda J. Yamamoto, Bruce M. Ewenstein
Journal: Blood (2010)
SAT0111 Increased Insulin Resistance and Impaired Beta-Cell Function in Patients with Rheumatoid Arthritis: Could Inflammation Fully Explain These Metabolic Disturbances?: Table 1.
Authors: G.G. Ristic, V. Subota, D. Stanisavljevic, B. Glisic, M. Petronijevic, D. Stefanovic
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Chronic inflammation, the basic feature of rheumatoid arthritis (RA), plays a major role in accelerated atherosclerosis through its influence on insulin resistance (IR), lipid status, and other risk factors. <h3>Objectives</h3> To investigate the level of IR and β-cell function in RA pts compared to healthy controls and evaluate whether inflammation can explain these metabolic disturbances. <h3>Methods</h3> The study population included 127 nondiabetic subjects (90 RA pts and 37 matched healthy controls). We determined body mass index (BMI), waist circumference (WC), presence of hypertension and metabolic syndrome (MetS). All pts were on disease modifying antirheumatic drugs (93.3% on methotrexate), 65.6% on steroids (median 5 mg/day, range 5–10, none on steroids &gt;10 mg/day), and 27.8% on biologic therapy. Laboratory analyses included inflammation markers (SE, hsCRP, IL-6), glucose, insulin, and C peptide (as a marker of insulin secretion). IR was calculated using the updated-computer Homeostasis Model Assessment (HOMA2-IR), based on fasting plasma glucose and specific insulin concentrations. Serum specific insulin was measured by a sensitive ELISA, which employs a monoclonal antibody to insulin. The output of the HOMA2 model was calibrated to give IR of 1 as normal. Therefore, values were considered abnormal when HOMA2-IR was &gt;1. <h3>Results</h3> Insulin resistance (HOMA2-IR&gt;1) was detected in 67/90 (74.4%) of RA pts and in 20/37 (54.2%) of controls, p=0.025. RA pts had significantly higher concentration of specific insulin, C peptide and HOMA2-IR than healthy controls, while HOMA2-B was not statistically different. Importantly, both groups were comparable regarding all other factors known to affect glucose metabolism in the general population (age, WC, presence of hypertension or MetS). As it was expected we found significant differences in inflammation markers between RA pts and controls: ESR 29.5 (14–44) vs. 16.0 (10.0–20.0); hsCRP 5.5 (2.8–15) vs. 3.0 (1.8–3.9); IL-6; 7.4 (2.0–18.8) vs. 2.0 (2.0–2.4); p&lt;0.000 for all. In logistic regression analysis, after adjustment for inflammation markers, statisticaly significant differences for HOMA2-IR and insulin became less important but still persisted (Table), while significance for C peptide disappeared. <h3>Conclusions</h3> RA pts had higher IR and impaired β-cell function in comparison to healthy controls. The persistence of statistical significance for IR after correction for inflammation markers, may implicate that the influence of inflammatory disease burden is important but not the only risk factor for IR in RA. <h3>Disclosure of Interest</h3> None declared
P0099 : Cholestatic liver fibrosis correlates with increased IL-17 and TGFβ-2 expression
Authors: M. Bueno-Topete, S. Zepeda-Morales, L. García-Benavides, S. Del Toro-Arreola, E. Bastidas-Ramírez, M. Fafutis-Morris
Journal: Journal of Hepatology (2015)
Clinical Significance of Bone Marrow Imaging of Appendicular Skeletons By Low-Dose Multi-Detector Computed Tomography in Patients with Bone Marrow Failure Syndrome
Authors: Manabu Fujisawa, Yasuhito Suehara, Kota Fukumoto, Yoshiaki Usui, Kentaro Narita, Masami Takeuchi, Kosei Matsue
Journal: Blood (2015)
Gut Microbiota, Bacterial Translocation, and Interactions with Diet: Pathophysiological Links between Major Depressive Disorder and Non-Communicable Medical Comorbidities
Authors: Anastasiya Slyepchenko, Michael Maes, Felice N. Jacka, Cristiano A. Köhler, Tatiana Barichello, Roger S. McIntyre, Michael Berk, Iria Grande, Jane A. Foster, Eduard Vieta, André F. Carvalho
Journal: Psychotherapy and Psychosomatics (2016)

Persistent low-grade immune-inflammatory processes, oxidative and nitrosative stress (O&amp;NS), and hypothalamic-pituitary-adrenal axis activation are integral to the pathophysiology of major depressive disorder (MDD). The microbiome, intestinal compositional changes, and resultant bacterial translocation add a new element to the bidirectional interactions of the gut-brain axis; new evidence implicates these pathways in the patho-aetiology of MDD. In addition, abnormalities in the gut-brain axis are associated with several chronic non-communicable disorders, which frequently co-occur in individuals with MDD, including but not limited to irritable bowel syndrome (IBS), chronic fatigue syndrome (CFS), obesity, and type 2 diabetes mellitus (T2DM).We searched the PubMed/MEDLINE database up until May 1, 2016 for studies which investigated intestinal dysbiosis and bacterial translocation (the 'leaky gut') in the pathophysiology of MDD and co-occurring somatic comorbidities with an emphasis on IBS, CFS, obesity, and T2DM.The composition of the gut microbiota is influenced by several genetic and environmental factors (e.g. diet). Several lines of evidence indicate that gut-microbiota-diet interactions play a significant pathophysiological role in MDD and related medical comorbidities. Gut dysbiosis and the leaky gut may influence several pathways implicated in the biology of MDD, including but not limited to immune activation, O&amp;NS, and neuroplasticity cascades. However, methodological inconsistencies and limitations limit comparisons across studies.Intestinal dysbiosis and the leaky gut may constitute a key pathophysiological link between MDD and its medical comorbidities. This emerging literature opens relevant preventative and therapeutic perspectives.
Angiogenic Cytokines: Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor Levels in Serum of Children with Hematopoietic Malignancies and Solid Tumors.
Authors: Izabela Palgan, Mariusz Wysocki, Krzysztof Palgan, Robert Debski, Jan Styczynski
Journal: Blood (2004)
Acute Myeloid Leukemia-Derived Exosomes Transform Bone Marrow Niche into Leukemic Niche.
Authors: Bijender Kumar, Mayra Garcia, Lihong Weng, Xiaoman Lewis, Jodi Murakami, Xingbin Hu, Tinisha McDonald, David DiGiusto, Ashish Kumar, Ravi Bhatia, Ching-Cheng Chen
Journal: Blood (2014)
PO67LEVETIRACETAM MAY BE INDEPENDENTLY ASSOCIATED WITH HIGHER FATIGUE IN ADULT GLIOMA OUTPATIENTS
Authors: A.G. Rooney, K. Zienius, L. Heimans, S. Woltz, S. McNamara, R. Grant
Journal: Neuro-Oncology (2015)

INTRODUCTION: The widely used antiepileptic drug (AED) Levetiracetam has previously been associated with behavioural changes. We hypothesised that patients taking Levetiracetam would experience higher levels of fatigue than patients on other AEDs. METHOD: Secondary analysis of a prospective observational study. Clinically stable adult outpatients with cerebral glioma completed a Visual Analogue Scale for fatigue (range 0-100mm, called ‘high' if >60mm). AED prescription was prospectively recorded. RESULTS: N = 166 patients consented to participate in the parent study (61% male; mean age 49yrs; 70% high-grade glioma). Fatigue was commonly reported (high in 43%; 95%CI 35-50%). AEDs were prescribed singly or multiply to most patients (n = 113). Levetiracetam (LEV) was the most frequent AED monotherapy. With clinical and statistical significance, patients on LEV monotherapy reported higher fatigue (n = 33, mean = 57mm, SD 5.2, 95%CI 46-67mm) than those on monotherapy with any other AED (n = 50, mean = 43mm, SD 3.9, 95%CI 35-50mm, t-test p < 0.0001). Surprisingly, this association was independent of functional status (ANCOVA p = 0.04, LR p < 0.0001, R2 = 27.7). Patients on LEV were more than twice as likely to report high fatigue as patients on other AEDs (OR 2.7 [1.1-6.2]). We observed similar findings with polytherapy involving LEV. CONCLUSION: Therapy-related side effects reduce quality of life and treatment compliance while increasing healthcare costs. Our data suggest that fatigue may be more common with Levetiracetam therapy specifically. Specialist review of AED medication may benefit some glioma patients with severe or persistent fatigue. Explanatory biological mechanisms of LEV-specific fatigue could be experimentally pursued.
PWE-088a Should Meals Be Blocked During Ambulatory pH Monitoring?: Abstract PWE-088 Table 1
Authors: E Athanasakos, S Harrington, L Neilan, A Raeburn, N Zarate, A Emmanuel, R Sweis
Journal: Gut (2016)

<h3>Introduction</h3> The pH sensor cannot differentiate retrograde from anterograde bolus movement. Physiologists often block meals in pH studies to reduce the artefact of acid-containing food/fluids; however there is no clear evidence with regards to the appropriateness of this practice. The aim of this study was to compare results of ambulatory pH monitoring without and with meals blocked in patients being investigated for reflux symptoms. <h3>Methods</h3> Standard pH parameters were compared without and with meals blocked in consecutive patients presenting to University College London Hospital Oesophageal Unit, a tertiary referral centre. T-test was used for quantitative and chi-square for qualitative variables. Results are presented as mean±standard deviation(SD) <h3>Results</h3> pH studies for 99 patients with reflux-like symptoms were collected prospectively over 3 months. Under 17 hour recordings (n = 2) or studies ON acid-reducing therapy (n = 6) were excluded. Mean age of the 91 remaining patients (M31:F60) was 50±15 years. Time spent without and with meals blocked was 1388±100 and 1243±114 minutes respectively (p &lt; 0.001); 145±111 min difference. There was no difference in the quantitative or qualitative Total reflux (% time pH &lt; 4; TR), Upright reflux (UR) or Supine Reflux (SR) when analysed without and with meals excluded.(Table) At individual level, meal exclusion changed TR/UR/SR to become negative in 4 and positive in 2 patients; average 5% (range 2.5–23 min) of the mealtime was taken up swallowing acid-containing products. Food diary occasionally provided guidance, although quality of self-reports was widely variable. There was no difference in qualitative (p = 0.538) or quantitative (p = 0.338) Symptom Index (SI) when meals were not blocked (12 positive; mean 16.9±22.6%) compared to when meals were blocked (16 positive; mean 18.4±25.4%). Also there was no difference in any pH parameters between the two groups with all symptoms pooled, or with typical (heartburn, regurgitation, chest pain; n = 59) and atypical symptoms (laryngopharyngeal reflux, cough, belch, dysphagia; n = 33) analysed separately (p = NS for all). Furthermore there was no difference in any pH parameter when results were analysed with (n = 43) or without (n = 48) a hiatus hernia (p = NS for all). <h3>Conclusion</h3> In 93% of patients, routine blocking of meals had no impact on the final report. In a small minority, the artefact of swallowing acidic products as well as shortening of the 24 hour study to exclude meals (average ≥2 hours) can also change results from positive to negative and vice versa. <h3>Disclosure of Interest</h3> None Declared
Phosphorus Magnetic Resonance Spectroscopy Predicts Outcome to Chemotherapy In Patients with Diffuse Large B-Cell Lymphoma: A Prospective International Multicenter Analysis of a Pretreatment Metabolic Biomarker of Response
Authors: Fernando Arias-Mendoza, Geoffrey Payne, Kristen Zakian, Marion Stubbs, Hamed Mojahed, Adam Schwarz, Amita Shukla-Dave, Franklyn Howe, Harish Poptani, Seung-Cheol Lee, Mitchell R Smith, Owen A. O'Connor, Ruth Pettengell, Stephen J. Schuster, David Cunningham, Martin O. Leach, Jason A. Koutcher, John R. Griffiths, Arend Heerschap, Jerry D. Glickson, Truman R. Brown
Journal: Blood (2010)
Peripheral T-Cell Lymphomas with Follicular Growth Patterns Are Derived from Follicular Helper T Cells (TFH): A Link with Angioimmunoblastic T-Cell Lymphomas?.
Authors: Yenlin Huang, Anne Moreau, Jehan Dupuis, Berthold Streubel, Barbara Petit, S. Legouill, Nadine Martin-Garcia, Christiane Copie-Bergman, Fanny Gaillard, Anne-Catherine Baglin, Josette Briere, Giovanna Roncador, Corinne Haioun, Marie-Helene Delfau-Larue, Andreas Chott, Philippe Gaulard
Journal: Blood (2007)
Haemophagocytic Lymphohistiocytosis Following Fludarabine/Cyclophosphamide Chemotherapy for Chronic Lymphocytic Leukaemia
Authors: Deepa Ranjani Jayakody Arachchillage, Samuel Moses, Stephen O'Brien, Tobias Menne, Peter Carey, Fiona Keenan, Jonathan Wallis
Journal: Blood (2011)
3-year safety follow-up of radium-223 dichloride (Ra-223) in patients (Pts) with castration resistant prostate cancer (CRPC) and symptomatic bone metastases (Mets) from ALSYMPCA
Authors: D. Amadori, C. Rossetti, M. Aglietta, C. Messina, A. Versari, N.J. Vogelzang, A. Sartor, R.E. Coleman, S. Govi, F. Fang, I. Skjorestad, S. Nilsson, C. Parker
Journal: Annals of Oncology (2015)
Coping strategies, alexithymia and anxiety in young patients with food allergy
Authors: L. Polloni, A. DunnGalvin, E. Ferruzza, R. Bonaguro, F. Lazzarotto, A. Toniolo, N. Celegato, A. Muraro
Journal: Allergy (2016)

Food allergy is major public health concern affecting nearly 15 million Americans and 80 million Europeans. Risk of anaphylaxis and implications for social activities affect patients' quality of life and psychological well-being. We previously found that young patients reported higher levels of alexithymia (difficulty in recognizing and expressing emotions) compared with healthy peers and may influence affect, management style and clinical outcomes. This study aimed to explore links between coping strategies, alexithymia and anxiety among food-allergic adolescents and young adults.Ninety-two patients with IgE-mediated food allergy (mean age 18.6 years) completed Coping Orientation to Problems Experienced Inventory, Toronto Alexithymia Scale and Trait Anxiety subscale of State-Trait Anxiety Inventory. Multivariate analyses of variance assessed differences and associations between subgroups on the scales.Significant differences found between alexithymia levels in coping style were explained by Avoidance strategies. 'Avoidance' had the highest contribution in explaining alexithymia, followed by trait anxiety, age, anaphylaxis and social support. Respondents with higher alexithymia use avoidance as coping strategy over and above other coping strategies such as problem-solving and positive thinking, are younger, will have experienced anaphylaxis and will have lower social support.Recognizing the specific role of affect regulation in health behaviours may constitute an important step in supporting patients to explore more adaptive strategies.
Synergistic Lethal Effects Between Gemcitabine and Arsenic Trioxide on Non-Hodgkin Lymphoma Cell Lines Is Associated with Modulation of PI3K/Akt Signaling Pathway
Authors: Mingwan Zhang, Xiaojun Xu, Yongbin Ye, Ziwen Guo, Xiaochun Bai, Jing Wang, Ruiqing Zhou, Dafa Qiu, Huiqing He, Xin He, Wenfang Yi, Guangyang Weng, Guo Kunyuan
Journal: Blood (2014)
In Vitro Expansion of Human Hematopoietic Cells with Delayed but Sustained Multi-Lineage Repopulating Activity
Authors: Alice M.S. Cheung, Stefan Wohrer, Paul H. Miller, Suzan Imren, Shabnam Rostamirad, Kiran Dhillon, David Knapp, Robert A.J. Oostendorp, R. Keith Humphries, Connie J. Eaves
Journal: Blood (2011)