tbuckley/cabot-search huggingface dataset:
PTH-115 Increasing Access to Hepatitis C Treatment in The North East of England
Authors: S Welsh, M Valappil, C Miller, E Robinson, A Price, M Schmid, S Masson, S McPherson
Journal: Gut (2016)

<h3>Introduction</h3> Chronic infection with hepatitis C (HCV) is a major cause of cirrhosis and hepatocellular carcinoma. Many patients are now eligible for oral direct acting antivirals (DAAs), with cure rates &gt;90% possible. The main challenge for viral hepatitis teams now is to engage known HCV infected individuals in treatment, and to find undiagnosed cases. There are an estimated 2000 HCV infected individuals in North of Tyne (NOT) Region (Newcastle, North Tyneside and Northumberland). However, it is unknown what proportion of HCV infected individuals diagnosed in this region ultimately receive treatment. <h3>Aim</h3> 1) To determine the proportion of HCV infected individuals in our region who were referred for treatment, received treatment and achieved a sustained virological response (SVR). 2) To determine whether contact can be made with patients who never had HCV RNA confirmatory testing, were never referred, or persistently missed clinic appointments. <h3>Methods</h3> We conducted a retrospective review of all patients with a NEW positive HCV antibody test between Jan 2011 and Dec 2012 in the NOT region. Patients were identified from the North East Public Health Laboratory. Medical records and treatment databases were accessed to establish outcomes for all patients. For patients never referred or lost to follow up a letter was sent to their GP advising them to contact the patient and discuss re-referral. <h3>Results</h3> Overall 92% of HCV antibody positive patients have HCV RNA testing performed (Figure 1). 88% of HCV RNA positive patients are referred for consideration for treatment. Of these, 47% commenced antiviral therapy, with an overall SVR of 66%. Persistent non-attendance was the main reason for not starting treatment. Letters were sent to GPs of 77 patients who were never referred or were lost to follow up. The GP response rate was 31% (24/77) after 8 weeks. Six (8%) patients were re-referred to the service. <h3>Conclusion</h3> There is a high rate of referral for HCV RNA positive patients (88%) in the North of Tyne region, with 47% commencing PEG-IFN based treatment. Some reasons for not starting treatment should resolve in the DAA era, increasing treatment rates.Contacting GPs to re-refer known HCV RNA positive patients is an inexpensive approach, but resulted in relatively few referrals. Improving HCV testing across the region is essential to increase access to treatment. <h3>Disclosure of Interest</h3> None Declared
Phase 1/2 Trial of the XIAP Antisense Oligonucleotide (AEG35156) in Combination with Idarubicin and Cytarabine in Patients with Relapsed/Refractory AML
Authors: Aaron D Schimmer, Elihu H Estey, Gautam Borthakur, Bing Carter, Gary J. Schiller, Martin S. Tallman, Jessica K Altman, Judith E. Karp, Jeannine Kassis, Christine Jacob, Stephen Morris, Jacques Jolivet, Michael Andreeff
Journal: Blood (2008)
Magnetic Ressonance Imaging (MRI) in the Evaluation of Iron Overload in Patients with Beta Thalassaemia. The Brazilian National Program Preliminary Results.
Authors: Nelson Hamerschlak, Laercio Rosemberg, Alexandre Parma, Fernanda F. Assir, Frederico R. Moreira, Jose R. Parga, Edson Amaro, Morrhy Samira, Lira Edgar, Fisher Claudio, Loggeto Sandra, Verissimo Monica, Araujo Aderson, Baldanzi Giorgio, Fabron Antonio, Velloso Claudia, Steagall A. Merula, Tricta Fernando, Cury Alexandre, Vieira Marcelo, Funari G. Marcelo, Magao S. Fernanda, Nogueira C. Joice
Journal: Blood (2005)
Significance of a Single Human Leukocyte Antigen Mismatch on the Outcome of Nonmyeloablative Allogeneic Stem Cell Transplantation from Related Donors Using the Mexican Schedule.
Authors: Guillermo J. Ruiz-Arguelles, Briceida López-Martínez, Carlos Manzano, J. D. Gómez-Rangel
Journal: Blood (2004)
Reduced-Intensity Unrelated Cord Blood Transplantation in Adult – a Single Center Analysis of 318 Transplants.
Authors: Shuichi Taniguchi, Atsushi Wake, Kazuhiro Masuoka, Naoyuki Uchida, Naofumi Matsuno, Shinsuke Takagi, Hisashi Yamamoto, Masanori Tsuji, Kazuya Ishiwata, Yoshimi Mayumi, Kimiko Sagawa, Madoka Narita, Shigeyoshi Makino, Hideki Araoka, Akiko Yoneyama
Journal: Blood (2008)
Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study
Authors: John S. House, Annah B. Wyss, Jane A. Hoppin, Marie Richards, Stuart Long, David M. Umbach, Paul K. Henneberger, Laura E. Beane Freeman, Dale P. Sandler, Elizabeth Long O'Connell, Christie Barker-Cummings, Stephanie J. London
Journal: Journal of Allergy and Clinical Immunology (2016)
NIMG-72TRACKING THE PYRAMIDAL TRACT IN TUMOUR PATIENTS USING DIFFERENT FUNCTIONAL LOCALIZER METHODS: PLAUSIBILITY OF DTI-TRACTS USING FUNCTIONAL MRI VS. NAVIGATED TRANSCRANIAL MAGNETIC STIMULATION
Authors: Irada Tursunova, Volker Neuschmelting, Hannah Lockau, Charlotte Nettekoven, Ana-Maria Oros-Peusquens, Gabriele Stoffels, Andrea Maria Faymonville, Christian Grefkes, Roland Goldbrunner, Carolin Weiss Lucas
Journal: Neuro-Oncology (2015)

INTRODUCTION: Imaging of the course of the corticospinal tract (CST) by diffusion tensor imaging (DTI) is useful for function-preserving tumour surgery especially of gliomas infiltrating the white matter. The integration of functional data such as functional MRI (fMRI) or navigated transcranial magnetic stimulation (nTMS) for the delineation of starting Regions of Interest (ROI) can improve the fibre tracking results in a multiple-ROI approach. Here, both functional localizer methods are compared for the plausibility of the resulting fibre course. METHODS: 32 patients with intracerebral tumours were allocated to the prospective study. The cortical seeding ROIs were defined by the nTMS hot-spots or by the fMRI local-activation-maximum representing the primary motor area (M1) of the hand, the foot and the tongue. The CST originating from the contralesional M1 hand area was mapped as intra-individual reference. As subcortical ROI, we used the anterior inferior pontine region (aiP). The plausibility of the fibre trajectories was assessed by a-priori defined anatomical criteria by two independent raters. As potential co-factors i.a. the franctional anisotropy threshold (FAT) was analysed. RESULTS: Both methods revealed excellent plausibility results for the contralesional hand-CST (100%). NTMS seems to be favourable to construct the hand-CST on the lesional side (NTMS/fMRI: 97%/81%) whereas no significant difference could be observed for the foot- and the tongue-CST. Plausibility rates were significantly deteriorated at low FAT values (ROC-cut-off: FAT = 0.105) for both nTMS- and fMRI-derived CST (p < 0.001). The interrater reliability was excellent (Cohen's k = 0.96). CONCLUSIONS: In summary, we found excellent plausibility rates using a deterministic multiple-ROI approach with a cortical ROI defined by functional localizer methods. In comparison, nTMS was advantageous for the hand-CST tractography whereas both localizer methods revealed adequate results for the foot- and the tongue-CST. In general, tractography results at FAT lower than 0.105 should be interpreted with particular caution.
All-Payer Claims Databases — Uses and Expanded Prospects after <i>Gobeille</i>
Authors: John D. Freedman, Linda Green, Bruce E. Landon
Journal: New England Journal of Medicine (2016)

To permit research that could improve health care system functioning, some states have established all-payer claims databases. Though a March 2016 Supreme Court decision prohibited state-mandated reporting from self-insured employer plans, it suggested a path forward.
OC-037 A Perianal Swab-Based PCR Assay for Diagnosing Colonisation by Pathogenic C.difficile
Authors: NM Joshi, E Taylor, RM  , A Whiley, M Wilks, D Rampton
Journal: Gut (2016)

<h3>Introduction</h3> C.difficile is a Gram-positive anaerobe that can cause life-threatening diarrhoea. There is no current method with which to identify pathogenic C.difficile colonisation (PCDC) quickly. In order to be pathogenic, C.difficile must have the ability to make toxin B. We have designed and validated an rtPCR assay targeting the toxin B with which to diagnose PCDC quickly using a perianal swab. <h3>Methods</h3> Perianal swabs were taken prospectively from 99 patients with proven stool culture-positive C.difficile infection (CDI) within 24 hours of diagnosis. DNA from swab tips was extracted using the automated QIAsymphony platform. Half of the DNA extracts from patients with CDI along with control C.difficile DNA were used to optimise an rtPCR assay using primers targeting the C.difficile toxin B gene. PCRs were run as 10μL reactions on 96 well plates in duplicate and the volume of extract per reaction was varied (1–3μL). PCR positive was defined as: amplification curve crossing the threshold at &lt;40 cycles, &lt;0.5 CT difference between duplicates, melting points to be ± 1.25 OC of that of C.difficile DNA and no amplification in negative controls. PCR positivity was compared to culture result as the gold standard. Once optimised, the assay was validated using the remaining 48 DNA extracts from CDI patients and extracts from swabs taken from 11 control patients with C.difficile-negative diarrhoea. <h3>Results</h3> In optimisation, assay sensitivity increased as more DNA extract was added (40%, 62% and 78% for 1μL, 2μL and 3μL respectively, p = 0.0042). The 3μL assay showed 92% efficiency and linearity of 0.997 was selected for the validation study. For validation using perianal swabs from 48 patients with proven CDI and 11 C.difficile stool culture-negative patients, assay sensitivity was 69%, specificity 93%, positive predictive value (PPV) 97% and negative predictive value (NPV) 48%. <h3>Conclusion</h3> We designed an rtPCR assay to identify C.difficile toxin B in DNA extracted from perianal swabs taken from patients with diarrhoea. Although the sensitivity in the validation experiments was low (69%), the high specificity and PPV mean that the assay may have clinical applicability. As almost all patients testing positive with the PCR swab test will be colonised with pathogenic C.difficile, they could be isolated on hospital admission to reduce the chance of nosocomial spread. Patients testing positive could also be prospectively followed to see if colonisation with pathogenic C.difficile on admission is a risk factor for subsequent C.difficile-induced diarrhoea (CDI), poorer outcome if diagnosed with CDI, or relapsing disease. <h3>Disclosure of Interest</h3> None Declared
Severe Pulmonary Adverse Events in Healthy Unrelated Donors of Peripheral Blood Stem Cells Following G-CSF Administration,
Authors: Katrin Wetzko, Matthias Blechschmidt, Kristina Hölig, Kirsten Poppe-Thiede, Susanne Ganepola, Roman Fischbach, Rainer Ordemann, Michael Laniado, Bernhard Schulte-Hubbert, Markus Schuler, Livia Cotta, Dietrich Braumann, Gerhard Ehninger, Frank Kroschinsky
Journal: Blood (2011)
Multivariate Survival Analysis of Transformed Lymphoma in the Chemoimmunotherapy Era: Impact of the NCCN International Prognostic Index
Authors: Patrick T. Griffin, Samir Dalia, Bijal D. Shah, Lubomir Sokol, Celeste M. Bello, Paul A. Chervenick, Eduardo M. Sotomayor, Julio C Chavez
Journal: Blood (2014)
FRI0127 Angiogenic Placental Factors during Pregnancy in Rheumatoid Arthritis
Authors: F. Förger, M. Baumann, L. Risch, L. Raio, D. Surbek, U. Wiedemann, A. Zbinden
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Reduced birth weight in infants born to women with rheumatoid arthritis (RA) is often related to active maternal disease during pregnancy. <h3>Objectives</h3> We hypothesized that RA might have an influence on placental function and investigated whether pro-angiogenic and anti-angiogenic placental proteins such as placental growths factors (PLGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) were differently regulated in patients with RA compared to healthy controls. <h3>Methods</h3> Sera of 27 pregnancies in RA patients and of 10 aged-matched healthy women were analyzed for PLGF and sFLT-1 by ELISA once at each trimester (gestational week 10–12, 20–22 and 30–32). Disease activity of all RA patients was measured by DAS28-CRP and CRP. Neonatal birth weights and birth weight percentiles were correlated with PLGF- and sFLT-1- levels. <h3>Results</h3> Of the 37 pregnancies there was no case of preeclampsia, neither in the group of RA patients nor in the group of healthy controls. Median birth weight of the newborns from RA patients was 2890 g (range 1250–4000). Among all pregnancies of RA patients, the levels of PLGF and sFLT-1 were similar in active and inactive disease. At the third trimester of pregnancy, RA patients showed lower levels of the pro-angiogenic placental protein PLGF than healthy controls (P=0.021). By contrast, levels of the anti-angiogenic protein sFLT-1 did not differ between RA patients and healthy women. The sFLT-1/PLGF ratio was lower in healthy women than in RA patients (P=0.021). Moreover the sFLT-1/PLGF ratio showed a negative correlation with the birth weight percentile. <h3>Conclusions</h3> RA patients showed reduced levels of the pro-angiogenic placental protein PLGF which might reflect a dysfunction of the placenta with an effect on birth weight in this disease. <h3>Disclosure of Interest</h3> None declared
Dynamics of cerebral blood flow in patients with mild non‐ischaemic heart failure
Authors: Christian D. Erkelens, Haye H. van der Wal, Bauke M. de Jong, Jan‐Willem Elting, Remco Renken, Marleen Gerritsen, Peter Jan van Laar, Vincent M. van Deursen, Peter van der Meer, Dirk J. van Veldhuisen, Adriaan A. Voors, Gert‐Jan Luijckx
Journal: European Journal of Heart Failure (2016)
Maximum Standard Uptake Value (SUVmax) on FDG-PET Imaging Predicts Time to First Treatment in Patients with Low Grade Follicular Lymphoma,
Authors: Jakub Svoboda, Elise A. Chong, Emeline R Chong, Sunita D. Nasta, Drew Torigian, Abass Alavi, Stephen J. Schuster
Journal: Blood (2011)
Intense Uptake in Amyloidosis of the Seminal Vesicles on 68Ga-PSMA PET Mimicking Locally Advanced Prostate Cancer
Authors: Maximilian Stephens, David Insoo Kim, Benjamin Shepherd, Sonja Gustafson, Paul Thomas
Journal: Clinical Nuclear Medicine (2016)

We report a case of benign senile seminal vesicle amyloidosis demonstrating intense 68Ga–prostate-specific membrane antigen (PSMA) uptake on PET/CT. A 68-year-old man underwent staging PSMA PET/CT and MRI for biopsy-proven prostate adenocarcinoma. There was an intense focus of 68Ga-PSMA uptake in the primary malignancy, as well as symmetrical intense uptake in the seminal vesicles bilaterally that was reported as multifocal disease with local invasion. Final histology after radical prostatectomy showed amyloidosis of the seminal vesicles without any evidence of prostate cancer. Care should be taken in the interpretation of seminal vesicle PSMA uptake to avoid overstaging.
Miscalculation and Errors in Numbers Reported in Table
Authors: Andreas Beyerlein, Fabienne Wehweck, Anette-Gabriele Ziegler, Maren Pflueger
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
EPIG-04THE CHROMATIN LANDSCAPE OF MEDULLOBLASTOMA
Authors: Serap Erkek, Marc Zapatka, Lukas Chavez, Sebastian M. Waszak, Volker Hovestadt, Pascal D. Johann, Laura Sieber, David T. W. Jones, Marcel Kool, Peter Lichter, Jan O. Korbel, Paul A. Northcott, Stefan M. Pfister
Journal: Neuro-Oncology (2015)

Medulloblastoma is a highly malignant pediatric brain tumor characterized by four distinct molecular subgroups - WNT, SHH, Group 3 and Group 4 - each exhibiting disparate clinical features and tumor biology. Genomics has revealed considerable heterogeneity both between and within MB subgroups. Somatic alterations affecting chromatin-modifying genes are among the most penetrant driver events in medulloblastoma, occurring across patient subgroups and suggesting deregulation of the epigenome as an essential event during medulloblastoma pathogenesis. To date, however, the medulloblastoma epigenome remains largely unexplored. In this study, we used histone ChIP-sequencing to systematically characterize the medulloblastoma chromatin landscape in a series of 26 primary fresh-frozen cases encompassing all four subgroups. ChIP-seq performed for six histone marks (H3K4me3, H3K9me3, H3K27me3, H3K27ac, H3K4me1 and H3K36me3) enabled systematic discovery and annotation of chromatin states, revealing the differential representation of polycomb repressed, active promoter, and poised enhancer states across medulloblastoma subgroups. Intriguingly, coverage of the poised enhancer state was significantly higher in Group 4 compared to other medulloblastoma subgroups, exemplified by the priming of enhancers associated with genes involved in neuronal differentiation. Furthermore, integration of chromatin states with sample-matched RNA-seq data demonstrated that the expression of chromatin modifiers and cell cycle genes is correlative with the coverage of different chromatin states in the medulloblastoma epigenome. Ongoing efforts focus on the identification of chromatin state transitions between medulloblastoma subgroups and integration of orthogonal ‘omics’ data to further explore the link between chromatin-modifier deregulation and the epigenome. This comprehensive dataset describing the chromatin landscape of medulloblastoma will dramatically enhance our understanding of the epigenome underlying this malignancy and how it relates to both tumor biology and subgroup-specific cellular origins. These ‘omics’-driven insights are desperately needed to facilitate the development of improved treatment options for this molecularly heterogeneous childhood cancer impoverished of highly penetrant driver genetic events.
Systematic Drug Repositioning By Integrating Transcriptome and Historical Clinical Data, Identification of Digoxin As a Novel Drug Reposition Candidate for High-Risk Myelodysplastic Syndromes
Authors: Huojun Cao, Zheng Yin, Shenyi Chen, Timothy Liu, Jiyong Liu, Yaping Hu, Hong Zhao, Lawrence Rice, Swaminathan Padmanabhan Iyer, Stephen Wong
Journal: Blood (2015)
SP0043 Clinical Outcomes for Gout Patients in Rheumatological Care
Authors: T. Uhlig
Journal: Annals of the Rheumatic Diseases (2016)

With increased interest in gout and the advent of better management opportunities more attention has been paid to defining relevant outcomes in gout, also for use in clinical practice. International guidelines advocate treatment to below a threshold of 360 μmol/l (6 mg/dl) and below 300 μmol/l (5 mg/dl) if a patient has tophi. While this is the target for treatment, other outcome domains have been developed as part of OMERACT work. Identified outcomes for acute gout include mandatory core outcomes: pain, joint swelling, joint tenderness, patient global assessment of disease activity, and activity limitations. In addition there are additional domains for assessment which include: an acute phase marker of inflammation, work disability, joint impairment, joint erythema, and physician global assessment of disease activity. Many different instruments have been used to assess the acute gout core domains. In order to reduce existing variation, standardisation of measuring the most important domains of gout is recommended. In clinical practice flares indicate a failure of ongoing treatment of gout. On the other hand the development of a responder index is an area of investigation as is the definition of remission in gout. Ongoing research tries to define a time period in which a flare needs to be absent so the patient can be defined as in remission. <h3>Disclosure of Interest</h3> None declared
The Combination of Brentuximab Vedotin (Bv) and Bendamustine (B) Demonstrates Marked Activity in Heavily Treated Patients with Relapsed or Refractory Hodgkin Lymphoma (HL) and Anaplastic Large T-Cell Lymphoma (ALCL): Results of an International Multi Center Phase I/II Experience
Authors: Ahmed Sawas, Joseph M. Connors, John G. Kuruvilla, Celeste Rojas, Renee Lichtenstein, Ellen Neylon, Emily Lichtenstein, Changchun Deng, Jennifer E Amengual, Diego Villa, Michael Crump, Owen A. O'Connor
Journal: Blood (2015)
Tacrolimus and Sirolimus without Methotrexate as Acute GVHD Prophylaxis after Matched Related Donor Reduced Intensity Conditioning (RIC) Stem Cell Transplantation (SCT).
Authors: Vincent T. Ho, Haesook Kim, Shuli Li, Corey Cutler, John Koreth, Phillipe Armand, Robert J. Soiffer, Joseph H. Antin, Edwin P. Alyea
Journal: Blood (2007)
Two Specific Domains on the Upper Surface of the αIib β Propeller Determine the Sensitivity of αIibβ3 for RGD-Containing Peptides.
Authors: Ramesh B. Basani, Michael A. Thornton, Bruce S. Sachais, M. Anna Kowalska, William F. Degrado, Joel S. Bennett, Mortimer Poncz
Journal: Blood (2005)
Gene Expression Profiling of Polycomb and Polycomb-Regulated Genes in Patients with Acute Myeloid Leukaemia - Significance and Relationship to Other Molecular Aberrations.
Authors: Lykke C. Grubach, Caroline Juhl-Christensen, Anita Rethmeier, Lene H. Olesen, Peter Hokland, Mette Østergaard
Journal: Blood (2007)
Upregulation of Caspase 10 Contributes to Acquired Resistance of Acute T-Lymphoblastic Leukemia Cells to Proapoptotic Cytokine TRAIL.
Authors: Pavel Klener, Jan Molinsky, Marie Markova, Sergiu Leahomschi, Tereza Simonova, Ladislav Andera, Emanuel Necas, Jan Zivny
Journal: Blood (2009)