tbuckley/cabot-search huggingface dataset:
AB0833 An Internet Survey of Common Treatments Used by Patients with Gout
Authors: J.A. Singh, A. Bharat, L. Edwards
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Little is known about patients with gout with regards to the use of complimenatry and non-pharmacological approaches to treatment of gout. Qualitative work has shown that patients are interested in these treatment options. To our knowledge, there are no other studies of characteristics of patients who use supplements for gout. <h3>Objectives</h3> To assess the frequency of use of urate-lowering therapy (ULT) and natural supplements including cherry extract by patients with gout. <h3>Methods</h3> A pop-up on the website the Gout and Uric Acid Education Society9s website (http://gouteducation.org) informed people about the optional survey from 11/20/2013 to 01/15/14. The survey queried people regarding the use of ULT and supplements. <h3>Results</h3> Of the 162 survey respondents, 121 (74%) reported gout. Mean age of survey responders was 55.4 years (standard deviation, 14.5), 69% were men and 71% were White. Gout disease duration was ≤1 year in 29%, 1-5 years in 22%, 5-10 years in 22% and &gt;10 years in 21% (missing, 6%). Gout flares were common, with 89% with ≥1 gout flare in the last month (i.e. &gt;3/year). 51% had been prescribed allopurinol of febuxostat, 78% missed it for &lt;7 days/month. 42% participants were taking cherry extract or juice and 21% were taking other natural supplements. <h3>Conclusions</h3> Use of cherry extract and natural supplements is not uncommon in patients with gout. Only half of all gout patients were prescribed ULT by their providers. <h3>Acknowledgements</h3> We thanks gouteducation.org for displaying our survey. <h3>Disclosure of Interest</h3> J. Singh Grant/research support: Takeda, Savient, Consultant for: Takeda, Savient, Novartis, Allergan, Regeneron, A. Bharat: None declared, L. Edwards: None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4846
Abstract P5-06-01: Active pak6 induces aneuploidy in breast cancer cells.
Authors: BA Paul, ML Lu
Journal: Cancer Research (2012)

Abstract The natural history of breast cancer remains largely undefined. More than 50% of clinical specimens exhibit aneuploidy. Among these aneuploid cancers, nearly half have chromosome copy numbers approaching tetraploid. The high incidence of aneuploidy in advanced breast cancer is thought to be a byproduct of chromosome mis-segregation resulting from mutations in tumor suppressor genes regulating cell cycle checkpoints and corresponding to disease progression. However, recent large-scale sequencing projects have revealed that most tumors contain approximately 14–20 different mutant genes, suggesting heterogeneity exists throughout the genomes of cancer cells. This notion revives the concept that aneuploidy resulting from chromosome mis-segregation or other similar mechanisms may play an active role leading to transformation and disease progression. A novel p21-activated kinase 6 (PAK6) was recently identified to be an androgen receptor (AR) and estrogen receptor (ER) interacting protein. An estrogen-stimulated PAK6 activation was observed in BT474 breast cancer cells. This activation is mediated by estrogen-stimulated activation of PKA. At the cellular level, active PAK6 promotes transformation to metastatic phenotypes in MCF7 breast cancer cells as evidenced by increases in cell motility, matrigel invasion, and soft agar growth. Further characterization of MCF7 cells expressing a constitutively active PAK6 mutant revealed an accumulation of cells with higher ploidy as compared to that of parental cells. Using a proteomic approach to determine the PAK6 downstream target, we identified that Cdt1, a DNA pre-replicative complex subunit, is overexpressed in response to PAK6 activation. In eukaryotes, the expression and stability of Cdt1 are strictly regulated to ensure only one round of DNA replication in each cell cycle. Deregulated overexpression of Cdt1 has previously been demonstrated to induce aneuploidy and malignant transformation due to re-initiation of DNA replication within the same S-phase. The identification of Cdt1 overexpression in response to PAK6 activation provides a plausible mechanism for the observed accumulation of higher ploidy cells in MCF7 cells expressing active PAK6. Taken together these findings suggest a direct link between hormonal signals, DNA replication, and maintenance of genomic integrity. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-06-01.
Bursitis and Tenosynovitis Due to <i>Mycobacterium avium</i> Complex
Authors: Jacob C Dutilh, Babette van Hees
Journal: New England Journal of Medicine (2015)

A 58-year-old woman presented with painless swellings around several joints and drenching night sweats. Aspiration of the bursae revealed pus in three distinct locations; culture of the pus grew Mycobacterium avium complex.
Abstract 3308: Axl is required for EMT-induced stem cell traits and metastasis in breast cancer
Authors: Crina Tiron, Ingunn Stefansson, Hallvard Haugen, Tone Sandal, Emmet McCormack, Bjørn Tore Gjertsen, David Micklem, Johanna Ivaska, Lars Akslen, James Lorens
Journal: Cancer Research (2012)

Abstract Epithelial-to-mesenchymal transition (EMT) endows carcinoma cells with migratory, survival and stem cell-like attributes that facilitate metastasis. We have shown that expression of the receptor tyrosine kinase Axl in primary breast cancer is a strong independent predictor of poor overall survival and is further enhanced in matched patient metastases. Axl is upregulated by EMT-induction in mammary epithelial cells and establishes an autocrine signaling loop with its ligand, Gas6. Axl signaling is required to maintain the mesenchymal and stem cell-like phenotype induced by EMT-transcription factors. Axl-inhibition downregulated mesenchymal and stem cell marker expression, blocked invasiveness, inhibited mammosphere formation and reversed drug resistance. Axl knockdown completely prevented the spread of metastatic breast carcinoma cells from the mammary gland and increased overall survival in two different orthotopic breast cancer models. Axl was also required for breast cancer cells to extravasate into the lung following intravenous injection. These results suggest that Axl signaling is necessary for metastasis, stem cell and therapy resistance traits in breast cancer. Hence, Axl-inhibition represents a novel therapeutic opportunity to target stem-like and drug resistant breast cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3308. doi:1538-7445.AM2012-3308
PARE0007 Better living my rheumatoid arthritis : a validated website
Authors: S. Trope Chirol, A. Szczygiel, G. Thibaud
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> the democratization of access to the Internet has dramatically changed the behavior of patients. The number of searches related to health topics is growing. Every month in France, 165,000 searches are made with the key word "inflammation" and 74,000 with "rheumatoid arthritis" (RA). Many websites are available and it becomes difficult to identify reliable sources. At the same time, few resources are available to those affected by juvenile idiopathic arthritis (JIA). <h3>Objectives</h3> Enable patients to access reliable information 24/7 on RA and JIA through a website focusing on quality of life. <h3>Methods</h3> The Patients Association ANDAR interviewed 10 rheumatologists across France on the relevance of this project and the reasons that would lead them to invite their patients to visit the website. A focus group consisting of five patients (4 JIA and 1 PR), a rheumatologist with a double expertise (pediatric and adult) and a representative of the association was held. The ANDAR volunteers were also involved in the creative choices and contents revision. An agency specialized in communication with the young audience was mandated. <h3>Results</h3> Rheumatologists were enthusiastic and gave many recommendations: –the website should not only be designed to address teenagers but also young adults and adults; –JIA and RA should be distinct; Thanks to a collaborative work of the association, the focus group and the agency, 19 dossiers were developed, gathered in 4 chapters : "Understanding and managing my disease", "Better enjoying my everyday life", "Better moving around" and "Better enjoying my family". Each chapter offers a FAQ, tips and tricks as well as testimonials and external resources (links). The writing is definitely accessible and friendly, blog style to create a bond with the reader: "BETTER LIVING MY RHEUMATOID ARTHRITIS.COM", the website that unlocks ... your fixed opinions about RA !" <h3>Conclusions</h3> In 11 months the website www.mieux-vivre-ma-pr.com received 29,000 visits of 4 minutes on average. The most popular pages are those related to RA treatment and nutrition. An upgraded version will be available in Q2 2013 with more content (a 3D movie about the disease, more FAQ, quizzes, a new home page to optimize SEO and adding social networking features). <h3>Acknowledgements</h3> Thanks to : the rheumatologists who have been interviewed and gave their input, the members of the focus group, Dr. Julien Wipff, Dr. J David Cohen, the Junium agency. This work was supported by AbbVie <h3>Disclosure of Interest</h3> None Declared
NUEVAS APLICACIONES PARA UNA TERAPÉUTICA CONSOLIDADA: INFUSIÓN DE DUODOPA MEDIANTE SONDA DE GASTROSTOMÍA MODIFICADA A DUODENO
Authors: O Nogales Rincón, B Merino Rodríguez, L Holguera Ortiz, C González Asanza, E Cos Arregui, P Menchén Fernández Pacheco
Journal: Endoscopy (2012)

Introducción: la gastrostomía endoscópica percutánea (PEG) es una técnica ampliamente utilizada en la endoscopia, principalmente para mejorar el soporte nutricional. De manera marginal se ha utilizado como método de descompresión en caso de obstrucción intestinal o para la infusión de medicaciones. La colocación de una sonda PEG específica (PEG-Duodopa) para infusión continua con bomba de un preparado de Levodopa y carbidopa monohidrato en formulación gel (Duodopa) parece permitir un manejo adecuado de pacientes con enfermedad de Parkinson refractaria (EPR). Material y método: se incluyeron todos los pacientes remitidos por el Servicio de Neurología para la colocación de una sonda PEG-Duodopa en el HGU Gregorio Marañón, entre Enero/2010 hasta Mayo/2012. Se recogieron las características demográficas de los pacientes, eventos endoscópicos y anestésicos durante la colocación de la sonda, incluyendo éxito técnico, y complicaciones tempranas y tardías de la técnica, así como la necesidad de intervenciones endoscópicas posteriores (recambio y retirada de sondas). Resultados: se incluyeron 14 pacientes con EPR desde el inicio de la técnica en nuestro centro. La distribución por sexos V/M fue de 4/10. La edad media fue de 66,5 años (rango 54–76 años). El tiempo medio de evolución de la enfermedad fue de 15,7 años (rango 7–40 años). El éxito en el control de la sintomatología motora se alcanzó en 14/14 pacientes (100%). La colocación de la sonda PEG-Duodopa se logró en todos los pacientes (14/14), sin complicaciones anestésicas asociadas. El tiempo medio para su colocación fue de 18 minutos (rango 10–29 minutos), disminuyendo en relación con la curva de aprendizaje de la técnica. Se produjeron complicaciones en 6/14 pacientes (42%): lo más frecuente fue la infección alrededor del orificio de PEG en 4/14 pacientes, no complicada, que se resolvió con tratamiento antibiótico, salvo en un paciente que presentó infección tardía del orificio (>1 mes tras su colocación), y que requirió retirada de PEG-Duodopa hasta su resolución, con recolocación posterior. Un paciente presentó un neumoperitoneo sintomático con ileo paralítico asociado, que se resolvió de manera conservadora. Otro paciente presentó neumoperitoneo complicado tras extracción de sonda mediante tracción externa, que requirió intervención quirúrgica urgente, con buena evolución posterior. Estos 14 pacientes han requerido la colocación de 23 sondas a lo largo del tiempo de seguimiento (1,3 sondas/paciente/año), habitualmente por desconexión del sistema de la sonda pigtail duodenal. Conclusiones: la colocación de una sonda PEG para infusión de Duodopa es una técnica de gran utilidad para el grupo de pacientes con enfermedad de Parkinson refractaria a terapias estándar. Es necesario vigilar la aparición de complicaciones tras la exploración, especialmente la infección del orificio de gastrostomía.
Successful treatment of acute gastric volvulus by emergency endoscopic reduction in a patient with cerebral palsy
Authors: Serta Kılınçalp, Hakan Akinci, Şahin Çoban
Journal: Endoscopy (2014)

A 25-year-old man with mixed dystonic/spastic cerebral palsy was admitted to our emergency department with a 12-hour history of severe abdominal pain, abdominal distension, and retching. His medical history was otherwise unremarkable. Physical examination revealed a distended, tympanic mass in the left upper quadrant and epigastric region. The results of laboratory investigations were unremarkable.
Nation Calls for Increased Yew Tree Collection
Authors: M. Folkemer, S. Bennett
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Nation Calls for Increased Yew Tree Collection Get access Mary Folkemer, Mary Folkemer Search for other works by this author on: Oxford Academic PubMed Google Scholar Sylvia Bennett Sylvia Bennett Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 7, April 1992, Pages 479–480, https://doi.org/10.1093/jnci/84.7.479 Published: 01 April 1992
P200 Use of hypertonic saline in bronchoprovocation for the diagnosis of bronchial asthma
Authors: S. M. A. Al Mamun
Journal: Thorax (2011)

<h3>Purpose</h3> To find out a simple, chief, standard &amp; easily available agent for bronchoprovocation &amp; also to determine the provocating dose of hypertonic saline, which will reduce at least 20% of FEV<sub>1</sub> in bronchial asthma patient. <h3>Methods</h3> A prospective case control study was carried out among 50 patients with bronchial asthma and 50 normal healthy control at Asthma centre in NIDCH, Bangladesh. Hypertonic saline of different concentration in doubling doses (1.8%, 3.6%, 7.2%), sequentially from lower to higher concentration was inhaled to both group by nebuliser and the test was terminated when drop of at least 20% FEV<sub>1</sub> had occurred. Patients were selected according to prefixed inclusion &amp; exclusion criteria. Structured questionnaire was filled-up by each patient. Written consent was taken from every patient &amp; control after proper explanation about the procedure &amp; its outcome. <h3>Results</h3> In the control group M/F ratio was 1.27:1, age ranged from 11 years to 50 years and of 5 different occupations (student, service holder, businessman, housewife and worker). In patient group M:F was 1.38:1, age range from 11 to 50 years and five different occupation was same as control. There were no statistically significant differences between the two groups regarding age, sex and occupation. In control, graded amount of hypertonic saline (1.8%, 3.6%, 7.2%) was given by nebuliser inhalation. None of them showed fall of FEV<sub>1</sub> significantly (20%). But in patient group, with similar concentration of hypertonic saline inhalation, there was highly significant fall in FEV<sub>1</sub>, χ<sup>2</sup> test showed highly significant value, χ<sup>2</sup>=75.42 and p&lt;0.001. <h3>Conclusion</h3> Hypertonic saline induced broncho provocation is actually very safe, simple &amp; cheap. So the people of third world countries can afford this test in minimum cost. Provocative dose of Hypertonic saline is 7.2% (20% fall of FEV<sub>1</sub>). <h3>Clinical implications</h3> For the diagnosis of cough variant asthma &amp; also in the suspected cases of bronchial asthma, we can performed this test confidently.
Occipital Calcification and Celiac Disease
Authors: Rubens Gisbert Cury, Camila Hobi Moreira
Journal: New England Journal of Medicine (2014)

A 24-year-old man presented with a 10-year history of recurrent episodes of throbbing, occipital headache associated with complex visual symptoms, lasting from a few minutes to an hour. He had been treated for migraine, with little response.
LOWER PLAQUE LIPID CONTENT ON NEAR-INFRARED SPECTROSCOPY IN STATIN-TREATED PATIENTS: INSIGHTS FROM THE COLOR REGISTRY
Authors: Stephen J. Nicholls, Jordan Andrews, Alex Janssan, Akiko Maehara, Mitsuaki Matsumura, Myong Hwa Yamamoto, Annapoorna Kini, Jonathan Tobis, Simon Dixon, Priti Shah, Gregg Stone, James Muller, Gary Mintz, Giora Weisz
Journal: Journal of the American College of Cardiology (2016)
A1.19 Zinc and cadmium homeostasis is altered in rheumatoid arthritis synoviocytes
Authors: Paola Bonaventura, Fabien Lavocat, Giulia Benedetti, Aline Lambroux, Francis Albarede, Pierre Miossec
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease with uncontrolled proliferation of synoviocytes. Pro-inflammatory cytokines, notably IL-17 and TNF-α contribute to RA perpetuation. Zinc (Zn) is critical for the function of the immune system and its homeostasis is controlledby ZIPs importers, ZnTs exporters and Metallothioneins (MTs), metal binding proteins in cytosol. The aim of the work is the study of the homeostasis of Zn and other metals in RA compared to Osteoarthritis (OA) synoviocytes. <h3>Materials and Methods</h3> A metal-enriched culture medium (Cadmium (Cd), Indium, Tin, Lead, Bismuth) was prepared with or without Zn (2ppm), IL-17 and TNF-α. Metal levels were studied by Induced-Coupled-Plasma Mass Spectrometry after a two week culture to estimate their Dissociation Constant cells/medium ((K<sub>D</sub>) = (Me/Zn)cells/(Me/Zn)medium; Me: metal). mRNAs of Zn trafficking molecules were quantified by qRT-PCR in cells first treated overnight with or without IL-17 and TNF-α, then with addition or not of Zn (0.9 ppm) for 6 hours. Cd was added to inhibit Zn activity. <h3>Results</h3> Metal quantification showed that Cd is preferentially absorbed by synoviocytes (OA, RA) compared to Zn (K<sub>D</sub> Cd/Zn = 100). IL-17 and TNF-α addition had a low effect on ZIP-8 but not on ZnT1 and MTs mRNA in both cells. Increasing Zn concentration (0.4, 0.9, 3.6 ppm) proportionally modified transporter expression and cytokines/Zn co-exposure enhanced their expression. MTs expression significantly increased with Cd exposure in comparison to the control situation (p &lt; 0.01), which was further enhanced with cytokines. Controversially, addition of small amount (0.9 ppm) of Zn in the presence of Cd (0.1 ppm) reduced the Cd-induced MTs expression in both cell types. Importantly, the effects of Cd/Zn or cytokine addition were reduced in RA vs. OA synoviocytes resulting in a reduced apoptotic ratio of RA synoviocytes measured by Annexin V staining. <h3>Conclusion</h3> Synoviocytes (OA, RA) preferentially absorb Cd, regardless to its toxicity. Homeostasis of Zn and Cd is modified in RA compared to OA synoviocytes. This could explain their resistance to apoptosis and their uncontrolled proliferation. Moreover addition of Zn could reduce Cd-induced apoptosis.
UTILIZATION OF HEMODYNAMIC SUPPORT IN STATUS 1A PATIENTS AWAITING HEART TRANSPLANT: INSIGHT FROM UNITED NETWORK OF ORGAN SHARING (UNOS)
Authors: Sachin Kumar, Sadeer Al-Kindi, Mobolaji Ige, Chantal Elamm, Mahazarin Ginwalla, Guilherme Oliveira
Journal: Journal of the American College of Cardiology (2015)
Eosinophil Response to Adrenocortical Stimulation in Peptic-Ulcer Disease
Authors: Alvin J. Cummins, Michael L. Gompertz, Marie H. Jones
Journal: New England Journal of Medicine (1957)

THERE is considerable evidence that the administration of adrenocortical steroids or ACTH to human subjects produces increased gastric acid and uropepsin output.1 , 2 These studies, as well as numerous reports of the production, activation or aggravation of peptic ulcers in patients receiving these hormones,3 have led to the suspicion that hyperadrenocorticism is involved in some way in the pathogenesis of human peptic-ulcer disease. Surprisingly few investigations have been made, however, to attempt proof of this supposition. In 1951 Turner4 reported deficient eosinophil response to adrenocortical stimulation with subcutaneously administered epinephrine (0.3 mg.) and intramuscularly administered aqueous ACTH (25 mg.) in 43 . . .
1057 BASIGIN PREDICTS ADVANCED DISEASE IN HEPATOCELLULAR CARCINOMA
Authors: A. Lee, A.P. Rode, A.J. Nicoll, L. Lim, S. Lim, P. Angus, I. Kronborg, N. Arachchi, E. Prakoso, F.J. Warner, S.V. McLennan, N.A. Shackel
Journal: Journal of Hepatology (2012)
AB0107 Sonic hedgehog promotes survival and apoptosis resistance through smoothened protein in human umbilical vein endothelial cell
Authors: S. Zhu, J. Huang, W. Peng, M. Wang, J. Gu
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is characterized by chronic synovitis and pannus formation, leading to destruction of cartilage and bone. Sonic Hedgehog (Shh) signaling pathway plays significant role in regulating the morphogenesis during development and promotes angiogenesis in tumor. Earlier studies showed that endothelial cell apoptosis may play a major regulatory role in neovascularization. <h3>Objectives</h3> We investigated the expression level of Smoothened(Smo) in endothelial cells in synovial tissue from patients with RA and analyzed the expression of Shh signaling pathway components(Shh, Ptch1, Smo and Gli1) in human umbilical vein endothelial cell line (EA.hy926 cell) and examined the effect of Smo protein on endothelial cell survival and apoptosis. <h3>Methods</h3> The expression of Shh signaling pathway component Smo in synovial tissues from 4 RA patients and 4 patients with traumatic or meniscal injury was examined by immunohistochemistry assay. EA.hy926 cells were used as the model of human umbilical vein endothelial cells. Shh, Ptch1, Smo, Gli1 mRNA expression levels in EA.hy926 cells exposed to TNFα with or without specific Shh signaling pathway inhibitor(Cyclopamine) were detected by Real time-PCR, and the protein expression levels were measured by Western blot analysis.EA.hy926 cells were treated with different concentrations of Cyclopamine or transfected with the small interfering RNA (siRNA) specifically targeting Smo gene before exposure to TNFα and actinomycinD (ActD). The cell survival rate was detected by CCK-8 assay and the cell apoptotic rate was examined by flow cytometry. <h3>Results</h3> Smo was highly expressed in synovial tissue in RA, especially in endothelial cells than that in control group. TNFα significantly increased the mRNA and protein expression of Shh signaling pathway components in EA.hy926 cells, while the expression was decreased in the presence of TNFα and Cyclopamine. EA.hy926 cells treated with Cyclopamine or transfected with Smo-siRNA showed a significant decrease in cell viability, with decreased cell survival rates and increased apoptotic rates, compared with those of the control group. <h3>Conclusions</h3> Shh signaling pathway may play a role in the regulatory of apoptosis in endothelial cells in RA synovium and promote angiogenesis. <h3>References</h3> Gravallese EM. Bone destruction in arthritis. Ann Rheum Dis. 2002. 61 Suppl 2: ii84-6. Dimmeler S, Zeiher AM. Endothelial cell apoptosis in angiogenesis and vessel regression. Circ Res. 2000. 87(6): 434-9. Varjosalo M, Taipale J. Hedgehog: functions and mechanisms. Genes Dev. 2008. 22(18): 2454-72. <h3>Disclosure of Interest</h3> None Declared
Jejunal Diverticular Hemorrhage Localized by Red Blood Cell Scintigraphy
Authors: DAVID M. SCHUSTER, WILLIAM E. CHAPMAN, ERNEST T. AHL, PAUL AHEARNE
Journal: Clinical Nuclear Medicine (2001)

SCHUSTER, DAVID M. M.D.; CHAPMAN, WILLIAM E. M.D.; AHL, ERNEST T. M.D.; AHEARNE, PAUL M.D. Author Information