tbuckley/cabot-search huggingface dataset:
AB0351 Risk Factors of Coronary Artery Stenosis in Patients with Rheumatiod Arthritis
Authors: H. Gerasimova, D. Kolmakova, O. Fomicheva, D. Novikova, T. Popkova, Y. Karpov, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) patients (pts) have increased cardiovascular (CV) morbidity and mortality. Coronary angiography (CAG) is the gold standard to identify and assess the degree of coronary artery (CA) involvement. CAD development in RA pts is associated with the accumulation of traditional risk factors and immunological mechanisms. RA therapy may also contribute to CAD development. <h3>Objectives</h3> To determine clinical predictors and contribution of anti-rheumatic therapy on development of CA stenosis in RA patients. <h3>Methods</h3> This is a prospective study of 63 RA pts (25 men and 38 women, mean age 58 [52; 63] years, with a long history of the disease (10,5 [7; 23] years), seropositive for IgM rheumatoid factor (RF) (82%) and anti-cyclic citrullinated peptide (ACCP) (58%), with moderate to high clinical disease activity DAS 28 =4,7 [3,3; 5,8]). All pts underwent CA angiography. Pts were divided into two groups: Group (1)- RA pts with significant stenosis (&gt;50%) of at least one CA (n=22), Group (2) – pts without coronary stenosis (n=41). The study compared clinical characteristics and RA therapies in two groups. <h3>Results</h3> Groups were comparable in terms of age, disease duration and DAS 28 scores. Males prevailed in Group 1: 15/22 (68%) vs 10/41 (24%) in Group 2 (<i>p</i>&lt;0,05). The prevalence of traditional risk factors was similar in both groups: hypertension - 77% and 88%, dyslipidemia - 26% and 33%, diabetes mellitus - 5% and 17%, smoking – 45% and 17%, physical inactivity - 58% and 42%, obesity - 45% and 32% pts in Group 1 and 2, respectively. Serum HDL cholesterol concentrations in Group 1 (1,2 [1,0; 1.5]mmol/l) was lower, than in Group 2 (1,55 [1,3; 2.0]mmol/l, <i>p</i> =0,03). CVD incidence was higher in Group 1pts with coronary stenosis, i.e.: history of MI 32% vs 2%; CAD - 77% vs 32% pts with and without CA stenosis, respectively <i>p</i>&lt;0,05. Carotid artery atherosclerotic plaques were detected in 19% and 16%, thickening of the intima-media - in 53% and 56% pts from Group 1 and 2, respectively, <i>p</i>&gt;0,05. Patients received the following treatment (Group 1 vs Group 2): methotrexate (MTX) (45% vs 85%), leflunomide (13% vs 7%), sulfasalazine (9% vs 2%), biological therapy (18% vs 20%), glucocorticiods (GCs) (54% vs 54%). There were no differences in almost all drugs dosing regiments, with the only exclusion: MTX doses were somewhat lower in Group 1 (10 [10; 15]mg/week) pts as compared to Group 2 (17,5 [12; 25] mg/week), <i>p</i>=0,07). Duration of GCs therapy was higher in Group 1 pts (5,3 [4; 12] years) vs (3,1 [1,5; 8], <i>p</i>&lt;0,05) Group 2. <h3>Conclusions</h3> Male gender, low HDL cholesterol and long-term GCs therapy seem to increase the risk of coronary artery stenosis in RA pts. <h3>Disclosure of Interest</h3> None declared
Pemoline and urinary excretion of catecholamines and indoleamines in children with attention deficit disorder
Authors: A J Zametkin, M Linnoila, F Karoum, R Sallee
Journal: American Journal of Psychiatry (1986)

To test the hypothesis that any change in urinary noradrenergic excretion accompanies drug-induced improvement in attention deficit disorder with hyperactivity, the authors gave pemoline (mean dose, 2.9 mg/kg of body weight) to 11 boys with this disorder in a 4-week open trial. Pemoline administration improved behavior but did not significantly change urinary catecholamine excretion. Serotonin excretion was unchanged, but phenylethylamine (PEA) and 5-hydroxyindoleacetic acid (5-HIAA) were significantly decreased. Clinical responders and nonresponders did not differ with respect to baseline urinary monoamine excretion or change in PEA and 5-HIAA excretion.
Transdiaphragmatic endoscopic ultrasound-guided right hepaticogastrostomy for biliary drainage after Ivor-Lewis esophagectomy
Authors: Laurent Poincloux, Constance Hordonneau, Olivier Rouquette
Journal: Endoscopy (2016)

Two male patients, aged 64 years (case 1) and 62 years (case 2), developed obstructive jaundice after presenting with peritoneal carcinomatosis. The patients had previously undergone Ivor-Lewis esophagectomy for esophageal adenocarcinoma, and received perioperative chemotherapy 24 and 20 months, respectively, after the initial surgery.
Induction of Xenogeneic Graft-Versus-Host Disease through Administration of HuPBMC to Immune Deficient RAG2−/−γc−/− Mice: A Model for B Cell-Involvement in Chronic Graft-Versus-Host Disease.
Authors: Marijke C. Canninga-van Dijk, Rozemarijn S. van Rijn, Elles R. Simonetti, Marieke C. Hogenes, Saskia Smulders, Roel A. de Weger, Anton Hagenbeek, Jan G. van de Tweel, Leo F. Verdonck, Anton C.M. Martens, Saskia B. Ebeling
Journal: Blood (2005)
The contribution of UGT1A and ABCB1 to irinotecan-induced toxicity: A prospective pharmacogenetic study of patients with metastatic colorectal cancer.
Authors: E. Levesque, A. Bélanger, F. Couture, D. J. Jonker, L. Villeneuve, M. Harvey, C. Guillemette
Journal: Journal of Clinical Oncology (2010)

3101 Background: We investigated candidate pharmacogenetic markers of chemotherapy toxicity in a prospective study of metastatic colorectal cancer (mCRC) patients. Methods: We recruited115 mCRC patients treated with irinotecan-based chemotherapy. The primary objective was to assess the relationship between genetic variations and toxicity. Toxicity was prospectively evaluated according to NCI-CTCAE v3.0 criteria. The secondary objective was to explore the relationship between genetic markers and tumor response. Twenty polymorphisms in the UGT1A metabolic gene and 19 in the ABC/OATP transporter genes were assessed. Results: In univariate analyses, several functional UGT1A variants, including UGT1A1*28 (c. -54--53 TA7), as well as ABCC1 and ABCB1 variants were shown to significantly influence severe hematological toxicity. In multivariate analyses, UGT1A6 c.184 and UGT1A7 c.208 were associated with severe neutropenia (odds ratio [OR] 3.01, 95% CI [1.42-6.36], p=0.004; OR=2.53, 95% CI [1.19-5.35], p=0.016, respectively). In contrast, a newly defined UGT1A haplotype (H1a) corresponding to the reference sequence but varying in the 3'-UTR was highly predictive of the absence of severe neutropenia (OR=0.23, 95% CI [0.05-0.98], p=0.034). In addition, ABCB1 c.1236 was a predictor of severe delayed diarrhea (OR=2.35, 95% CI [1.21-5.23], p=0.024) and better response (OR=1.80, 95% CI [1.04-3.13], p=0.049), whereas UGT1A7 c.208 was associated gastrointestinal protection (OR=0.41, 95% CI [0.17-0.99], p=0.049). Conclusions: This study suggests that specific polymorphisms in the major detoxifying systems involving UGT1A and ABC transporters influence irinotecan-associated toxicity and drug response, and these polymorphisms should be considered to refine pharmacogenetics testing. This work is supported by the Canadian Institutes of Health Research. EL and ASB contributed equally. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Roche, sanofi-aventis
Case 37-1981
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Edward A. Nardell, Eugene J. Mark
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 71-year-old woman was admitted to the hospital because of dyspnea and cough.She was well until 10 days earlier, when a dry cough and mild exertional dyspnea developed. A physician prescribed pseudoephedrine and erythromycin, but the dyspnea worsened progressively and finally occurred at rest. On the day of admission an x-ray film of the chest was reported to be abnormal, and she was referred to this hospital.Two years before admission x-ray films of the chest, taken elsewhere, showed a 3-mm nodule in the right lung that was interpreted as consistent with a granuloma. There was . . .
European Immunization Week 2008: Progress towards regional goals
Authors: Collective WHO
Journal: Eurosurveillance (2008)

The World Health Organization (WHO) Regional Office for Europe established the European Immunization Week (EIW, http://www.euro.who.int/vaccine) in 2005 for three reasons: 1) to raise public awareness of the benefits of immunisation, 2) to support national immunisation systems, and 3) to provide a framework for mobilising public and political support for governmental efforts to protect the public through universal childhood immunisation.
SP0021 The Association Between Fatigue, Sleep and Physcial Activity in Patients with Rheumatoid Arthritis
Authors: K. Loeppenthin
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> It is well establish that absence of fatigue and good sleep are important for maintaining good physical and mental health. However, evidence shows that fatigue and poor sleep are prevalent and severe problems for patients with rheumatoid arthritis. Physical activity may both represent a health promoting behavior in addition as a strategy for symptom management. <h3>Aim</h3> The overall focus for the lecture will be on fatigue and sleep in addition to a health promotion and health prevention perspective of physical activity and in the context of fatigue and sleep. The specific focus areas will be on: 1) Physical activity in a health promotion perspective 2) The association between physical activity, fatigue and sleep in patients with rheumatoid arthritis 3) Perspectives of physical activity as a part of the management of symptoms related to rheumatoid arthritis <h3>Method</h3> The lecture is primary based on results from a qualitative study (n=16) with the aim to investigate the patients9 experience of physical activity maintenance, and a cross-sectional study (n=500), with the aim to examine the association between fatigue, sleep and physical activity in patients with rheumatoid arthritis. <h3>Results</h3> The qualitative study show that patients with rheumatoid arthritis experience maintenance of physical activity as important for a sense of wellbeing and increased control over bodily function and symptoms. Furthermore, the cross-sectional study documented a high prevalence (61%) of poor sleep in patients with rheumatoid arthritis and that different dimensions of fatigue are of importance for the association to physical activity and sleep respectively. <h3>Perspective</h3> The lecture will contribute with knowledge regarding the importance of symptom management for patients with rheumatoid arthritis, including the importance of implementing a health promotion perspective in clinical practice. <h3>Disclosure of Interest</h3> None declared
AB0491 Current Management Patterns of Synthetic Dmards for Rheumatoid Arthritis in the Clinical Practice Setting: Sar-Fame Study: Table 1.
Authors: B. Hernández Cruz, I. Ureña Garnica, R. Sánchez Parera, E. Rubio Romero, J. Calvo Gutiérrez, A. García Sánchez, C. Rodríguez Escalera, F. Navarro Sarabia
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The application of the "treat-to-target" strategy in rheumatoid arthritis requires being proactive in the management of the disease to get the better outcomes. The treatment changes in daily practice are directed to improve the efficacy and/or tolerance, and also reduce the toxicity. <h3>Objectives</h3> The present study aimed to describe the percentage of patients who suffered a change in their synthetic DMARD regimen due to loss of efficacy (LoE), adverse events (AEs), intolerance, and other reasons. Also the therapeutic strategies chosen by rheumatologists for management of synthetic DMARD after treatment failure were evaluated. <h3>Methods</h3> This retrospective, observational and multicenter study included patients diagnosed with RA (fulfillment of the ACR/EULAR 2010 diagnostic criteria) from 2008 to 2012, who have started on at least one synthetic DMARD within this period. Patients were included in a routine clinical visit performed in 2014. Patient clinical characteristics and previous/current medications for RA were retrospectively collected from patients9 medical records after the consensus of the participant rheumatologists in the study. Descriptive analysis of the data retrieved at the study visit in 2014 is presented. <h3>Results</h3> 12 sites in Andalucía (Spain) included 301 patients (mean age: 56.6±14.0; female: 71%; RA duration: 3.6±1.5), whose clinical characteristics are shown in the table. 57% of patients have received a single synthetic DMARD, with metothrexate (MTX) (57%), leflunomide (20%) and hydroxychloroquine (9%) as the most commonly DMARDs prescribed as monotherapy. During the study period, 69% of patients suffered ≥1 change in the first- or subsequent-line DMARDs for AEs, intolerance or LoE. Of the 341 changes registered, 42% were due to LoE, 28% due to AEs (31% liver disorders, 19% gastrointestinal symptoms), 14% due to intolerance, and the remaining 16% due to the following reasons: patient preference, lack of adherence, pregnancy plans and loss of follow-up. DMARD was definitely and temporarily interrupted in 35% and 8% of the cases, respectively. Both the addition of and the switch to another conventional DMARD occurred in 11%, and DMARD dosage was adjusted in 28% of the cases. <h3>Conclusions</h3> In clinical practice, MTX was the main DMARD prescribed for initial treatment. Most of all changes made in DMARD therapy (84%) were due to lack of efficacy, AEs and intolerance. Definitely interruptions (35%) and dosage adjustments (28%) were the therapeutic strategies mainly chosen by rheumatologists. <h3>Disclosure of Interest</h3> None declared
Consecutive Primary Carcinomas of Bronchus and Larynx
Authors: Joseph Goorwitch
Journal: JAMA (1963)

THE PHENOMENON OF primary carcinomas occurring simultaneously or consecutively in two or more organs is encountered not uncommonly in modern oncologic literature. However, an autopsy series of 234 multiple primary malignant neoplasms performed from 1926 to 1944 and reported by Warren and co-workers in 1932<sup>1</sup>and 1944<sup>2</sup>contained only a single instance of primary carcinoma of bronchus and larynx in the same patient. In a series of 113 patients with multiple primary malignant neoplasms who were treated surgically at the Mayo Clinic in 1937 and reported by Stalker and co-workers,<sup>3</sup>there was not a single primary carcinoma of bronchus and larynx in the same patient. In 1955 Cahan<sup>4</sup>reported 19 instances of this combination of primary neoplasms among 81 cases of multiple primary carcinomas which were collected over a period of 28 yr at the Memorial Center for Cancer and Allied Diseases. A recent published report
Endoscopic versus Open Vein-Graft Harvesting
Authors: Mark W Connolly, Robert S Poston
Journal: New England Journal of Medicine (2009)

To the Editor: Lopes and colleagues (July 16 issue) 1 report data on vein-graft harvesting techniques from the Project of Ex-vivo Vein Graft Engineering via Transfection IV (PREVENT IV) study and conclude that endoscopic vein-graft harvesting, as compared with open harvesting, is independently associated with increased vein-graft failure and adverse outcomes. In another analysis from the same study, 2 offpump and on-pump coronary-artery bypass grafting (CABG) were compared. An interesting finding was that with endoscopically harvested grafts, the probability of graft failure was significantly higher in the off-pump group than in the on-pump group (odds ratio, 1.78 vs. 1.27). In addition, vein grafts of poor or fair quality (as compared with those of good quality) had a significantly higher rate of failure with off-pump than with on-pump CABG. The failure rate of left internal thoracic artery grafts was about 8%, as compared with a failure rate of about 25% for vein grafts. The failure rate of grafts to the left anterior descending artery was much lower than that of grafts to the right coronary artery and circumflex arteries. The study by Lopes et al. does not adjust for the use of off-pump CABG or of left internal thoracic artery grafts. Furthermore, there is no information on the quality of the veins or of the target vessels. These are major omissions that may have an effect on the results and conclusions of the study.
Endoscopic ultrasound-guided duodenojejunal anastomosis to treat postsurgical Roux-en-Y hepaticojejunostomy stricture: a dream or a reality?
Authors: Massimiliano Mutignani, Raffaele Manta, Francesco Pugliese, Antonio Rampoldi, Lorenzo Dioscoridi, Edoardo Forti
Journal: Endoscopy (2015)

Roux-en-Y hepaticojejunostomy stricture develops in 8 % to 40 % of patients, and reintervention is frequently required [1] [2]. Surgery remains the gold standard to treat this problem. We present the case of a 67-year-old man with recurrent cholangitis due to benign stricture of a bilioenteric anastomosis. The patient had a history of sclerosing cholangitis and left hepatectomy with Roux-en-Y bilioenteric reconstruction.
Lobe-Specific Nodal Dissection for Clinical Stage I and II NSCLC: Japanese Multi-Institutional Retrospective Study Using a Propensity Score Analysis
Authors: Tomoyuki Hishida, Etsuo Miyaoka, Kohei Yokoi, Masahiro Tsuboi, Hisao Asamura, Katsuyuki Kiura, Kazuhisa Takahashi, Hirotoshi Dosaka-Akita, Hideo Kobayashi, Hiroshi Date, Hirohito Tada, Meinoshin Okumura, Ichiro Yoshino
Journal: Journal of Thoracic Oncology (2016)

ObjectivesThe purpose of this study was to assess the surgical outcomes according to the extent of mediastinal lymph node dissection for patients with NSCLC by using a nationwide registry database.MethodsFrom among 11,663 patients in a Japanese lung cancer registry study for 2004, 5392 patients with clinical stage (c-stage) I or II NSCLC that was completely resected by lobectomy and either systematic (SND) or lobe-specific nodal dissection (LSD) were enrolled. Patients who received preoperative therapy or had middle lobe tumor were excluded. In the LSD group, inferior mediastinal (subcarinal) nodes were not dissected for upper lobe tumors, and superior mediastinal nodes were not dissected for lower lobe tumors. To reduce the selection bias, an inverse probability of treatment weighting method using a propensity score was implemented.ResultsLSD and SND were performed in 1268 patients (23.5%) and 4124 patients (76.5%), respectively. The LSD group included more upper lobe and c-stage I tumors and less pathological N2 disease than the SND group. Extended pathological N2 disease outside LSD area was found in 3.2% of the SND group. The 5-year overall survival was 81.5% in the LSD group and 75.9% in the SND group. An inverse probability of treatment weighting–adjusted Cox model showed that LSD did not have a negative prognostic impact and instead was associated with favorable survival (hazard ratio = 0.68, 95% confidence interval: 0.60−0.77).ConclusionsThis retrospective registry study suggested that LSD is an alternative to SND for selected patients with c-stage I or II NSCLC. Future prospective studies are warranted to determine whether LSD is applicable and provides clinical benefit for the general population of patients with c-stage I or II NSCLC.
Is more better? Dose intensity in neuroblastoma.
Authors: J R Anderson, P F Coccia
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.6.902 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2033426 Is more better? Dose intensity in neuroblastoma. J R AndersonxJ R AndersonSearch for articles by this author , P F CocciaxP F CocciaSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.6.902 First Page PDF © 1991 by American Society of Clinical Oncology
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Authors: Stephanie Halford, Gerald Liew, Donna S. Mackay, Panagiotis I. Sergouniotis, Richard Holt, Suzanne Broadgate, Emanuela V. Volpi, Louise Ocaka, Anthony G. Robson, Graham E. Holder, Anthony T. Moore, Michel Michaelides, Andrew R. Webster
Journal: Ophthalmology (2015)
Medicine and books: The Audit Society: Rituals of Verification
Authors: Lois Quam
Journal: BMJ (1998)

Michael Power 

Oxford University Press, £19.99, pp 183 

ISBN 0 19 8289472 

This book is valuable precisely because of the obscurity of its subject. Very little has been written about the purpose, context, or process of auditing. This book, therefore, fills a gap. The obscurity of the topic also makes the book somewhat heavy going. It is a meaty, dense read. At times, the book tries to cover too much and requires the reader to work hard to keep engaged. 

Michael Power turns a critical eye towards his former audit profession. He is rightly critical of the current high status given to the act of observing rather than the act of doing. Doctors and NHS managers will enjoy this perspective as they try to cope with difficult clinical or administrative tasks. The auditor’s luxurious position, of passive and retrospective review, can cause doctors’ and managers’ decisions to seem faulty when, in fact, they may have been effective in the circumstances. The author cautions that the auditor’s superiority is misplaced. 

The book could easily and more effectively be divided into two separate books. A book is needed that describes the history and context of the audit profession and considers the reasons for the recent explosion in audit. In addition, a “how to” book on audit for the auditee would be beneficial. The author tries to cover both areas, resulting in a book that is harder to read than it needs to be. 

I would recommend this book for managers and physicians interested in understanding and appraising more critically the role of audit in their organisations. It has some helpful tools for avoiding the excessive focus on process, which can come as a result of audit. The manager’s job is to use audit as a tool for better performance and to make sure it does not become a hindrance to managerial and clinical innovation toward improved patient outcomes.
The Prevention of Tuberculosis
Authors: J P Zellweger
Journal: BMJ (1899)

Tuberculosis is transmitted by aerial route from an infected patient to a healthy subject and is facilitated when the receiver is immunologically sensitive. Even when the risk of transmission is low, measures should be taken to prevent emission of bacilli, their suspension in air and inhalation by sensitive subjects, especially immunodeficient subjects. Surveillance of hospital staff and preventive antituberculosis regimens are generally recommended, but often quite controversial.
QUANTITATIVE STUDIES OF BRUCELLA PRECIPITIN SYSTEMS
Authors: R. B. Pennell, I. F. Huddleson
Journal: The Journal of Experimental Medicine (1938)

It has been shown that the precipitation by the endoantigens of the three species of brucella of their homologous antibodies may be described by equations developed from the law of mass action. The endoantigens may be used for the accurate calibration of brucella antisera. The nitrogen-containing constituent of the endoantigens does not always seem to be intimately connected with the ability to precipitate the specific antibodies.