AB0218 Rheumatoid Factor Is Associated with More Parameters of The Disease Activity than Anti-Citrullinated Peptide Antibodies in Patients with Rheumatoid Arthritis
Authors: L.K. Damjanovska
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is an evolving disease. In order to have a tight control and treat it to target, different markers for the measurement of disease activity have been investigated. A new hope emerged with the appearance of the new diagnostic anti-citrullinated protein antibodies (ACPA), such as anti-CCP and antibodies against mutated citrullinated vimentin (anti-MCV). <h3>Objectives</h3> The aim of this study was to evaluate the association of ACPA and RF with the parameters of the disease activity and composite disease activity indices. <h3>Methods</h3> We performed a cross-sectional study with 220 participants: 95 RA patients, 95 Non-RA patients with systemic inflammatory diseases and 55 healthy controls (HC). Demographic data, laboratory data and physical examination were performed and radiographies taken. ACPA antibody were measured with ELISA method and RF was measured with conventional Latex test. <h3>Results</h3> The mean age of the patients was 50, mean disease duration 4,8 years and average disease activity DAS 28 4,83. The sensitivity and specificity of the Anti-MCV, anti-CCP and RF regarding Non-RA patients were as follows: sensitivity 0.72, 0.71 and 0.69 and specificity 0.82, 0.88 and 0.86, respectfully with the area under the curve 0.77, 0,80 and 0,77. Anti-MCV and Anti-CCP antibody positivity was associated with 8 parameters of the disease activity. The common parameters for all the 3 antibodies were ESR, CRP, DAS28 and SDAI. Anti-MCV positivity was associated with Anti-CCP (p&lt;0,001) but not with RF positivity, with higher platelet number, morning stiffness and swollen joint count with p&lt;0,05. Anti-CCP positivity was associated with anti-MCV and RF positivity and titer (p&lt;0,001) and it was exclusively associated with the higher Sharp van der Heijde radiography scores. RF positivity was associated with anti-CCP and anti-MCV positivity and titer, (p&lt;0,05 and 0,04), patient assessment of pain, SJC, TJC, DAS28, CDAI, SDAI and HAQ DI (p&lt;0,05). <h3>Conclusions</h3> ACPA antibodies should be further evaluated in association with parameters of RA disease activity but RF should not be neglected as well. <h3>References</h3> Toes R. van der Woude D. Anti citrullinated protein antibodies (ACPA) and rheumatoid arthritis. Acta Rheumatol Port. 36 (3); 205–207 Van Venrooij WJ, van Beers JJB, Prujin GJM. Anti-CCP antibodies: the past, the present and the future. Nature Reviews Rheumatology 2011; 7: 391–397 Ursum J, Nielen M, van Schaardenburg D, van der Horst A, et al. Antibodies to mutated citrullinated vimentin and disease activity score in early arthritis: a cohort study. Arthritis Research and Therapy 2008; 10: R12 Besada E, Nikolaisen C, Nossent H. Diagnostic value of antibodies against mutated citrullinated vimentin for rheumatoid arthritis. Clin Exp Rheumatol 2011; 29(1):85–8 Prujin GJM, Wiik A, van Venrooij WJ. The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis. Arthritis Research and Therapy 2010; 12:203 Luime JJ, Colin EM, Hazes JMW, Lubberts E. Does anti-MCV has additional value as serological marker in the diagnostic and prognostic work-up of patients with rheumatoid arthritis? A systematic review. Ann Rheum Dis 2010; 69: 337–344 <h3>Acknowledgement</h3> This study was supported by ILAR as a part of the ILAR 2009 project in FYR Macedonia. <h3>Disclosure of Interest</h3> None declared