tbuckley/cabot-search huggingface dataset:
Reply to "Uveal melanoma cells are resistant to EZH2 inhibition regardless of BAP1 status"
Authors: Lindsay M LaFave, Wendy Béguelin, Richard Koche, Matt Teater, Barbara Spitzer, Alan Chramiec, Efthymia Papalexi, Matthew D Keller, Todd Hricik, Katerina Konstantinoff, Jean-Baptiste Micol, Benjamin Durham, Sarah K Knutson, John E Campbell, Gil Blum, Xinxu Shi, Emma H Doud, Andrei V Krivtsov, Young Rock Chung, Inna Khodos, Elisa de Stanchina, Ouathek Ouerfelli, Prasad S Adusumilli, Paul M Thomas, Neil L Kelleher, Minkui Luo, Heike Keilhack, Omar Abdel-Wahab, Ari Melnick, Scott A Armstrong, Ross L Levine
Journal: Nature Medicine (2016)
Maintenance treatment and 6-month outcome for bulimic patients who respond to initial treatment
Authors: R L Pyle, J E Mitchell, E D Eckert, D Hatsukami, C Pomeroy, R Zimmerman
Journal: American Journal of Psychiatry (1990)

Bulimic subjects who responded to intensive group psychotherapy plus imipramine or placebo or to imipramine alone (N = 68) were assigned to 4-month maintenance with weekly support groups and/or medication (placebo or imipramine) and were evaluated 6 months after initial treatment (N = 61). Thirty percent of the subjects relapsed during the 6 months. Initial treatment with group psychotherapy plus placebo or imipramine was associated with a lower relapse rate than initial treatment with imipramine alone. Neither attendance at the maintenance group sessions nor imipramine maintenance was associated with better outcome.
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity
Authors: Tomokazu Souma, Stuart W. Tompson, Benjamin R. Thomson, Owen M. Siggs, Krishnakumar Kizhatil, Shinji Yamaguchi, Liang Feng, Vachiranee Limviphuvadh, Kristina N. Whisenhunt, Sebastian Maurer-Stroh, Tammy L. Yanovitch, Luba Kalaydjieva, Dimitar N. Azmanov, Simone Finzi, Lucia Mauri, Shahrbanou Javadiyan, Emmanuelle Souzeau, Tiger Zhou, Alex W. Hewitt, Bethany Kloss, Kathryn P. Burdon, David A. Mackey, Keri F. Allen, Jonathan B. Ruddle, Sing-Hui Lim, Steve Rozen, Khanh-Nhat Tran-Viet, Xiaorong Liu, Simon John, Janey L. Wiggs, Francesca Pasutto, Jamie E. Craig, Jing Jin, Susan E. Quaggin, Terri L. Young
Journal: Journal of Clinical Investigation (2016)

Primary congenital glaucoma (PCG) is a devastating eye disease and an important cause of childhood blindness worldwide. In PCG, defects in the anterior chamber aqueous humor outflow structures of the eye result in elevated intraocular pressure (IOP); however, the genes and molecular mechanisms involved in the etiology of these defects have not been fully characterized. Previously, we observed PCG-like phenotypes in transgenic mice that lack functional angiopoietin-TEK signaling. Herein, we identified rare TEK variants in 10 of 189 unrelated PCG families and demonstrated that each mutation results in haploinsufficiency due to protein loss of function. Multiple cellular mechanisms were responsible for the loss of protein function resulting from individual TEK variants, including an absence of normal protein production, protein aggregate formation, enhanced proteasomal degradation, altered subcellular localization, and reduced responsiveness to ligand stimulation. Further, in mice, hemizygosity for Tek led to the formation of severely hypomorphic Schlemm’s canal and trabecular meshwork, as well as elevated IOP, demonstrating that anterior chamber vascular development is sensitive to Tek gene dosage and the resulting decrease in angiopoietin-TEK signaling. Collectively, these results identify TEK mutations in patients with PCG that likely underlie disease and are transmitted in an autosomal dominant pattern with variable expressivity.
Collaboration between Ohio psychiatrists and the legislature to update commitment laws
Authors: V M Victoroff
Journal: American Journal of Psychiatry (1977)

The author describes how the Ohio Psychiatric Association (OPA) worked with the state legislature to ensure that the revision of Ohio's laws regarding involuntary commitment of the mentally ill reflected what psychiatrists felt to be in the best interests of patients. The OPA was successful in changing the definition of "persons subject to hospitalization by court order," in abolishing suggested 90-day and 180-day limits on the hospitalization of certain kinds of patients, in supporting the participation of psychologists in the admission process after the presence of a medical examiner had been affirmed, and in protecting the confidentiality of private patients' records.
PWE-288 Is computed tomographic colonography more useful than colonoscopy in 2 week wait patients?
Authors: A Gumber, C Ntala, G Kaur
Journal: Gut (2015)

<h3>Introduction</h3> CT colonography (CTC) is now widely available as the radiological imaging test for the colon, replacing barium enema. It is recommended that regular audit processes should be in place to audit the quality of CTC service provision against internationally agreed standards. This is especially important when considering the national bowel cancer screening programme with reference to FOB positive patients unfit for a colonoscopy and/or with incomplete colonoscopic examinations. The other advantage of CTC is the ability to detect extra colonic lesions at the same time as evaluating the colon. We aimed to audit our CTC practice with reference to endoscopic findings and to determine the value of any extra colonic lesions found on CTC, especially in our 2 week wait and bowel cancer screening patients. <h3>Method</h3> All patients who had a CTC performed over a period of 13 months were evaluated against the electronic record of endoscopic procedures. Of 264 patients who had a CTC, 78 also had a contemporaneous flexible sigmoidoscopy or colonoscopy performed. <h3>Results</h3> The main indications for an investigation of the colon were altered bowel habit (45%), anaemia (11%), abdominal pain (6.8%) and cancer/ polyp follow up (7.9%). The most common indication for CTC in the 264 patients reviewed was exclusion of synchronous colonic tumours in patients who had an incomplete colonoscopy (112 patients); 140 patients had been deemed unfit to have a colonoscopy and 12 patients declined one. 11 BCSP underwent CTC, 5 due to an incomplete scope and 6 were deemed unfit for colonoscopy. 68% of the CTC and endoscopic findings were in agreement. 19/78 endoscopic abnormalities were not picked up on CTC (24%). No cancers were missed on CTC. The most common positive findings were diverticular disease (24%) and polyps (14%). We found that 37.5% of patients had extra colonic abnormalities. There were no recorded complications. <h3>Conclusion</h3> It is essential to audit the quality of CTC service provision against standards set by the International CT Colonography Standards Collaboration and the NHS Bowel Cancer Screening Programme. In our institution, the correlation of CTC and endoscopic findings was reassuring. In addition, a large number of extra colonic abnormalities were detected using CTC, some of which were significant – this is especially important in the 2 week wait patients. Colonoscopy, however, still remains the gold standard investigation for the detection of colon related pathology. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Johnson CD, Chen MH, Toledano AY <i>et al</i>. Accuracy of CT colonography for detection of large adenomas and cancer. NEJM. 2008;359:1207–17 Burling D. Effect of Directed training on reader performance for CT colonography: multicenter study. Radiology. 2007;242:152–61 NICE guidelines CT Colonography. http://guidance.nice.org.uk/IPG129;2009
Fungus Ball
Authors: R S Mikkilineni, D Flores
Journal: New England Journal of Medicine (1995)

Figure 1. A 67-year-old man, adequately treated for tuberculosis 15 years previously, had a three-week history of hemoptysis that was not accompanied by fever, chills, malaise, night sweats, weight loss, or other systemic symptoms. He also had no chest pain, sputum production, or other pulmonary symptoms. He was not immunosuppressed. Linear tomography of the chest (Panel A) showed a cavity in the left upper lobe containing a round mass (large arrow) that was separated from the cavity wall by an air space (small arrow). Bronchoscopy performed preoperatively revealed no endobronchial lesion or tumor. Lobectomy was carried out for severe hemoptysis, . . .
Prevention of the spread of infection – the need for a family-centred approach to hygiene promotion
Authors: S Bloomfield, M Exner, G  M Fara, E A Scott
Journal: Eurosurveillance (2008)

Infectious diseases circulating in the home and community are a continuing and significant burden on the health and prosperity of the European community. They could, however, be significantly reduced by better standards of hygiene. Across Europe, public health is currently structured such that the separate aspects of hygiene in different settings (food hygiene, personal hygiene, handwashing, pandemic flu preparedness, patient empowerment etc.) are dealt with by separate agencies. If efforts to promote hygiene at community level are to be successful in changing behaviour, we need a concerted family-centred approach to ensure that a basic understanding of infectious disease agents and their mechanisms of spread, together with an understanding of a risk-based approach to hygiene, are promoted as part of the school curriculum and as part of public health campaigns. Alongside this, we also need unambiguous communication with the public on issues such as the hygiene hypothesis and environmental issues.
PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals
Authors: Riddhima Banga, Francesco Andrea Procopio, Alessandra Noto, Georgios Pollakis, Matthias Cavassini, Khalid Ohmiti, Jean-Marc Corpataux, Laurence de Leval, Giuseppe Pantaleo, Matthieu Perreau
Journal: Nature Medicine (2016)
Fish Oil Supplements
Authors: L Limon
Journal: JAMA (2014)

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SAT0580 Serum Salusin-Alpha is Increased in Patients with Psoriatic Arthritis
Authors: S. Kobak, M. Akyildiz, A. Gokduman, T. Atabay, H. Vural
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized with skin lesions and joint involvement. Mechanisms of developing early atherosclerosis in PsA patients is not elucidated yet. Salusin- α and salusin-β are two new bioactive molecules. Salusin-β has been reported to have pro-atherosclerotic effects, but salusin-α has anti-atherosclerotic effects. Mechanisms of atherosclerosis developing in PsA patients may be associated with salusins <h3>Objectives</h3> The purpose of this study was to identify the serum salusin-α and salusin-β levels in patients with PsA and to determine the possible relationship with the disease findings. <h3>Methods</h3> Forty patients diagnosed with PsA according to CASPAR classification criteria and 40healthy volunteers were included in the study. Demographic, clinical, laboratory and radiological data were recorded in all patients. Disease activity indexes (PASI, BASDAI, BASFI, HAQ) were recorded. Serum salusin-α and salusin-β level were measured by ELISA method. <h3>Results</h3> Among 40PsA patients 13 (32.5%)were males and 27 (67.5%) were female, mean age was 48.5year and mean disease duration was 2.4 year. Demographic and clinical assessment of patients were as follows: 20 (50%) patients had family history, 18 (45%) patients were smoker, 19 (47.5%) patients had HLA-B27 positivity, 33 (82.5%) had sacroiliitis, 36 (90%) had enthesitis, 23 (57.5%) had DIP joints and nail involvement, 26 (65%) had wrist involvement, and 11 (27.5%) had ankle involvement. 20 (50%) patients had elevated CRP level and 25 (62.5%) patients had elevated ESR level. Compared with the control group PsA patients had elevated serum salusin-α level (p=0.004). The relationship between serum salusin-α level and ankle arthritis and dactylitis were determined (p=0.04, p=0.03). Serum levels of salusin-β were similar in PsA patients and controls (p=0.285). Serum salusin-β level were correlated with ankle arthritis (p=0.02). <h3>Conclusions</h3> We found elevated serum salusin-α and normal serum salusin-β levels in PsA patients. Salusins may plays an important role in the pathogenesis of early atherosclerosis development in patients with PsA. In this regard, there is a need for multicenter prospective studies. <h3>Disclosure of Interest</h3> None declared
Nondisclosure of Financial Interest in Clinical Practice Guideline Development: An Intractable Problem?
Authors: Hilda Bastian
Journal: PLoS Medicine (2016)

This week in PLOS Medicine, Stelfox and colleagues [1] report that only half of a large sample of clinical practice guidelines included financial disclosure statements for committee members (51%).They were studying 290 national or international practice guidelines for medical professionals published by 95 organizations in the United States National Guideline Clearinghouse in 2012.That's about the same rate that Taylor and Giles found in 2004 [2] and Norris and colleagues found in 2010 [3].There may be even less transparency across the whole spectrum of clinical practice guidelines.The National Guideline Clearinghouse includes a selected group, all published in English.It's hard to know how reflective those are of guidelines generally.In the late 1990s, when Grilli and colleagues studied guidelines identified via MEDLINE, they found that 67% did not report any description at all of the professionals involved in developing the guidelines [4].A 2013 study of Danish specialty societies found that only one out of 45 guidelines disclosed financial interests the authors identified from an official national disclosure list [5], and a 2015 study of primary care guidelines found no statements about conflicts of interest in 69% [6].When guideline recommendations are controversial-and that's often-suspicion quickly turns to financial conflicts of interest.The perception of conflicts can call the reliability of a recommendation into question, and even more so if there was no disclosure.This new study adds fuel to those concerns.Stelfox and colleagues found that organizations with weaker policies on financial conflicts tended to make more positive recommendations about the use of biomedical products.
Differential Metabolic Responses of Susceptible and Resistant Mouse Leukemia Cells to 8-Azaguanine&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Dean Burk, John Laszlo, Jehu Hunter, Kent Wight, Mark Woods
Journal: JNCI Journal of the National Cancer Institute (1960)

Leukemia cells susceptible and resistant to 8-azaguanine have been studied with regard to direct metabolic changes in respiration and glycolysis produced by this drug. 8-Azaguanine caused a prompt and marked increase in glycolysis in vitro of susceptible cells but not of resistant cells, with concentrations of drug that ranged from about one-fourth to four times the pharmacologic level commonly employed (50 mg./kg.). Respiratory inhibition was observed in both types of cells, but at lower doses in the susceptible cells than in the resistant line. The increase in glycolysis and decrease in respiration were also observed in vitro following a single subcutaneous dose of 8-azaguanine given to mice bearing the susceptible cells. These metabolic effects observed in vitro tended to disappear after repeated daily exposure of the cells to the drug in vivo, and did so within a transplant generation. The significance of these findings is discussed in relation to a rationale of chemotherapy based on well-established metabolic properties characteristic of all cancer cells.
Fast-cycling bipolar disorder induced by withdrawal from long-term treatment with a tricyclic antidepressant
Authors: B D Jones, S Steinberg, G Chouinard
Journal: American Journal of Psychiatry (1984)

A unipolar depressed patient developed a fast-cycling bipolar disorder on abrupt discontinuation of long-term treatment with a tricyclic antidepressant. The case illustrates the potential for drug withdrawal to induce mood disturbance that is more severe than the original illness.
SAT0320 Clinical Features of Women with Gout Arthritis in Cameroon, Central Africa: Table 1.
Authors: F. Kemta Lekpa, M.S. Doualla
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Few data are available on clinical features of women with gouty arthritis in sub-Saharan Africa <h3>Objectives</h3> To assess differences in the clinical features of gouty arthritis between female and male patients in a sub-Saharan Cameroonian population <h3>Methods</h3> A cross-sectional study from January 2004 to December 2014 conducted in the Rheumatology Unit of the General Hospital, Douala, Cameroon. We included patients with diagnosis of gout according to 1977 ACR criteria. A comparison with male patients with gout was made <h3>Results</h3> We included 511 patients (415 men and 96 women). The main characteristics of patients are summarized in Table 1. Gout in women was characterized by an elevated age at onset, high frequency of fever during acute attacks, high frequency of hyperuricemia and uric acid crystals in the synovial fluid, greater prevalence of cardiovascular diseases, diuretics and low-dose aspirin intake. Women had fewer tophy than men (p&gt;0.05); also, women had more tophi at the distal and proximal interphalangeal joints than men. <h3>Conclusions</h3> Gout in women seems to present specific characteristics. Further studies are needed to better understand these differences <h3>Disclosure of Interest</h3> None declared
The Musical Footprint of Cushing Syndrome
Authors: Louis-Marie Terrier, Aymeric Amelot, Stéphane Velut, Patrick François, Ilyess Zemmoura
Journal: JAMA Internal Medicine (2016)

The adenoma was surgically removed by a transsphenoidal approach.The patient's postoperative course was uneventful.Normalization of 24-hour urinary free cortisol level was achieved 4 days after surgery (200 nmol/24 hours).Histological examination confirmed the diagnosis of corticotroph pituitary adenoma.At 6 months, postoperative MRI confirmed total resection of the adenoma (Figure 2B).The patient had lost 12 kg, the purple marks had significantly decreased, endocrine functions were normalized, and he now continues to play his guitar.
Impact of Node Status and Radiotherapy on Failure-Free Survival in Patients with Newly Diagnosed Non-Metastatic Prostate Cancer: Data from &gt;690 Patients in the Control Arm of the Stampede Trial
Authors: N. James, M. Spears, N.W. Clarke, M. Sydes, C. Parker, D. Dearnaley, J.M. Russell, A. Ritchie, G. Thalmann, J.S. de Bono, G. Attard, C. Amos, M.K. Parmar, M. Mason
Journal: Annals of Oncology (2014)
18F-FDG PET/CT Osteometabolic Activity in Metastatic Parathyroid Carcinoma
Authors: Rômulo Hermeto Bueno do Vale, Marcelo Araújo Queiroz, Artur Martins Novaes Coutinho, Carlos Alberto Buchpiguel, Marcos Roberto de Menezes
Journal: Clinical Nuclear Medicine (2016)

Parathyroid cancer is an uncommon type of malignancy, which is frequently associated with poor prognosis. Clinical manifestations are caused by elevated serum calcium and parathyroid hormone (PTH). Diagnostic imaging studies as neck ultrasonography, technetium Tc Tc-sestamibi whole body scintigraphy, CT, and MR are already established tools for this malignancy. Nevertheless, the role of F-FDG PET/CT remains unknown in this scenario, with few published studies in literature. Hence, in this article, we aimed to report an illustrative case of increased skeletal FDG uptake associated with high calcium and PTH levels.
SP0226 Biologic-Induced Immunodeficiency? Is it an Issue?
Authors: M.J. Santos
Journal: Annals of the Rheumatic Diseases (2015)

Biological therapies have transformed the paradigm of treatment of several inflammatory rheumatic diseases such as rheumatoid arthritis, spondyloarthritis, vasculitis or systemic lupus, among others. Since the first TNF antagonists, numerous molecules targeting other immune pathways (IL-1, IL-6, IL-17, IL-12/IL-23, B Lymphocytes and co-stimulation) have become broadly available and the use of biologics is increasing worldwide. Nevertheless, blocking and neutralizing major pro-inflammatory pathways, depleting B-cells and interfering with T-cell function lowers the threshold for infections. In fact, patients on biologics are at higher risk of infectious complications, including serious infections and rare opportunistic infections. This risk is not the same for all biologics, nor for all patients, and it represents a real issue that clinicians should be aware of, recognize promptly and anticipate whenever appropriated. This lecture aims to provide an overview of current knowledge on the infectious risk associated with the use of biologics, in particular of viral infections. Importantly, preventive strategies will be addressed. <h3>Disclosure of Interest</h3> None declared