tbuckley/cabot-search huggingface dataset:
P2-120: BH3 domain of BID induces potent and selective apoptosis of non-small cell lung cancer cells: mechanisms and implications for therapy
Authors: Alex Chacko, Nyree Crawford, Gary Coleman, Brett Greer, Pat Harriott, George McCartney, Anne-Marie Baird, Kenneth O'Byrne, Eyal Gotlieb, Dean A. Fennell
Journal: Journal of Thoracic Oncology (2007)
Psychological treatment of obesity with phentermine resin as an adjunct
Authors: C R Roberts
Journal: American Journal of Psychiatry (1978)

The author treated 12 patients who had demonstrated only a minimal response to psychiatric treatment alone for their obesity with a combination of psychotherapy and an anorectic, phentermine resin. Psychotherapy was directed toward developing an awareness of the underlying anxiety related to the problem of obesity and fostering the subsequent ability to change the pattern of overeating. All 12 patients were treated successfully, and 9 reached ideal weight. Weight loss was maintained or additional weight was lost when the medication was discontinued.
Low back pain
Authors: Cathy Speed
Journal: BMJ (2004)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Low back pain Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Does knee replacement surgery for osteoarthritis improve survival? The jury is still out
Authors: Devyani Misra, Na Lu, David Felson, Hyon K Choi, John Seeger, Thomas Einhorn, Tuhina Neogi, Yuqing Zhang
Journal: Annals of the Rheumatic Diseases (2016)

The relation of knee replacement (KR) surgery to all-cause mortality has not been well established owing to potential biases in previous studies. Thus, we aimed to examine the relation of KR to mortality risk among patients with knee osteoarthritis (OA) focusing on identifying biases that may threaten the validity of prior studies.We included knee OA subjects (ages 50-89 years) from The Health Improvement Network, an electronic medical records database in the UK. Risk of mortality among KR subjects was compared with propensity score-matched non-KR subjects. To explore residual confounding bias, subgroup analyses stratified by age and propensity scores were performed.Subjects with KR had 28% lower risk of mortality than non-KR subjects (HR 0.72, 95% CI 0.66 to 0.78). However, when stratified by age, protective effect was noted only in older age groups (>63 years) but not in younger subjects (≤63 years). Further, the mortality rate among KR subjects decreased as candidacy (propensity score) for KR increased among subjects with KR, but no such consistent trend was noted among non-KR subjects.While a protective effect of KR on mortality cannot be ruled out, findings of lower mortality among older KR subjects and those with higher propensity scores suggest that prognosis-based selection for KR may lead to intractable confounding by indication; hence, the protective effect of KR on all-cause mortality may be overestimated.
Report of Children's Cancer Study Group.
Authors: J D Rowley
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.1.1 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3965627 Report of Children's Cancer Study Group. J D RowleyxJ D RowleySearch for articles by this author https://doi.org/10.1200/JCO.1985.3.1.1 PDF "Report of Children's Cancer Study Group.." Journal of Clinical Oncology, 3(1), pp. 1–2© 1985 by American Society of Clinical Oncology
Brain Tumors
Authors: Janet M. Torpy
Journal: JAMA (2005)

Brain TumorsT umors (growths) may occur in the brain.These tumors may be benign (noncancerous) or malignant (cancerous).Even noncancerous tumors may cause compression of the brain tissue, so they may need to be aggressively treated or removed surgically.Malignant brain tumors may be primary (cancers of the brain tissue itself) or metastatic (spread from a cancer somewhere else in the body).The February 2, 2005, issue of JAMA includes an article about primary malignant brain tumors.
Commentary: “Double loop” learning
Authors: Ed Peile
Journal: BMJ (2004)

As well as sympathising with the patient, many respondents to this case commentary found themselves engaging in the difficulties faced by the general practitioner.1 Donald Schon, in Educating the Reflective Practitioner, described a “swampy lowland” wherein lie the problems of greatest human concern and where “messy, confusing problems defy technical solution.”2 Schon contrasts beautifully the technical and rational approaches of the theoretical high ground with the reflective approaches we often need in professional practice.
Case 78-1963
Authors: George Van S. Smith, Robert E. Scully
Journal: New England Journal of Medicine (1963)

Presentation of Case First admission. A forty-five-year-old woman entered the hospital because of severe anemia.Six years previously the patient consulted a physician because of fatigue and was told that she was anemic. She was given iron tablets and periodic injections of liver extract and felt better until one year before admission, when the symptoms recurred and the liver injections were resumed. The menses had always been regular and profuse, requiring five or six pads daily; two months before admission spotting occurred for twelve days. The most recent menstrual period began eight days before admission and lasted for two . . .
Valproate and spina bifida.
Authors: P Oakeshott, G M Hunt
Journal: BMJ (1989)

She said that the GMC "successfully kept the whole question of self regulation off the agenda."Although the absolute number of lay members was increased their proportion had decreased."It could be argued," she wrote, "that the act, rather than being a radical reform, was a revision, a revision which made it possible for a medical elite, as little changed as possible, to remain in power and for professional self- regulation to continue unchallenged."For Stacey the reforms of 1978 reunited the profession-which has so often threatened to split into factions of academics, royal colleges, and general practitioners-but did little for the public interest.Stacey thinks-with others-that self regulation looks anachronistic at the end of the twentieth century."A task," she said, "which now faces the profession, and commentators upon it, is to think through what might be viable alternatives, more appropriate for modern health care practice....
Clinical Usefulness of Ajcc Response Criteria in Stage Ii/Iii Breast Cancer Patients Who Treated with Long Course Neoadjuvant Chemotherapy
Authors: Y. Yang, S. Im, B. Keam, K. Lee, T. Kim, D. Oh, S. Han, T. Kim, W. Han, H. Moon, I.A. Park, D. Noh
Journal: Annals of Oncology (2014)
Correlates of anxiety in psychiatrically hospitalized children and their parents
Authors: J H Kashani, A F Vaidya, S M Soltys, A C Dandoy, L M Katz, J C Reid
Journal: American Journal of Psychiatry (1990)

The authors separated 100 children hospitalized in a child psychiatry service into three groups according to their level of anxiety on the basis of the responses of the children and their parents to diagnostic interviews. Differentiation of the groups of children was validated by independent test instruments. Results of tests administered to the children and their parents revealed significant relationships between anxiety in the adults and in the children. In addition, parents of anxious children reported more SCL-90-R symptoms as well as more negative family relations than parents of nonanxious children and the more severely anxious children had higher rates of dysthymia and negative life events.
PU.1 and Spi-B Oppose Transformation Of Pre-B Cells Through Activation Of Key Genes Involved In B Cell Receptor Signalling
Authors: Darah A. Christie, Shereen A. Turkistany, Li S. Xu, Stephen K. H. Li, Ian Welch, Heather C. Broughton, Gillian I. Bell, David A. Hess, Rodney P. DeKoter
Journal: Blood (2013)
Current status of measles immunization
Authors: V A FULGINITI
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Schedule-dependent edatrexate toxicity.
Authors: E A Perez
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.1.322 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8558215 Schedule-dependent edatrexate toxicity. E A PerezxE A PerezSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.1.322 PDF "Schedule-dependent edatrexate toxicity.." Journal of Clinical Oncology, 14(1), pp. 322–323© 1996 by American Society of Clinical Oncology
Phase II open-label, safety, pharmacokinetic and efficacy study of 2-methoxyestradiol nanocrystal colloidal dispersion administered orally to patients with recurrent glioblastoma multiforme
Authors: J. Kirkpatrick, A. Desjardins, J. Quinn, J. Rich, J. Vredenburgh, S. Sathornsumetee, S. Gururangan, C. Sidor, H. Friedman, D. Reardon
Journal: Journal of Clinical Oncology (2007)

2065 Background: 2-methoxyestradiol (2ME2) inhibits tumor cell proliferation and induces apoptosis by inhibiting microtubule polymerization and increasing reactive oxygen species-induced cell damage. In addition, 2ME2 downregulates HIF-1a at the posttranscriptional level and inhibits HIF-1a-mediated VEGF expression. Preclinical studies confirm significant in vitro and in vivo anti-glioma activity including tumor regression in combination with temozolomide. We therefore performed a single-center, phase 2 study to evaluate 2ME2 in recurrent glioblastoma multiforme (GBM) patients. Methods: Key eligibility include: adults with GBM at first or second recurrence; measurable disease; Karnofsky performance status = 70% and adequate organ function. 2ME2 was given orally 4 times/day at a dose of 1000mg for the first 11 patients and then escalated to 1500 mg for remaining patients. Patients are evaluated after every 28-day cycle. The primary efficacy endpoint is 6-month progression-free survival. Results: Sixteen patients (14 male) have been enrolled, including 7 at first recurrence and 9 at second recurrence. The median age is 52 years (range, 32–64 years). Thirty-five cycles have been administered to date. Grade II-IV, attributable toxicities include transaminase elevation (grade 3, n=3; grade 2, n=1); hypophosphatemia (grade 3, n=1); anorexia (grade 2, n=1) and rash (grade 2, n=1). Six patients (38%) have achieved stable disease including one minor response. PK studies revealed similar 2ME2 exposures to those achieved among solid tumor patients treated at the same dose level and no differences between GBM patients on or not on CYP3A-inducing anti-epileptic agents. Further accrual and follow-up is ongoing. Conclusions: Continuous daily 2ME2 dosing, administered as a monotherapeutic, is well tolerated and is associated with modest anti-tumor activity among recurrent GBM patients. Combination studies with temozolomide are underway. No significant financial relationships to disclose.
Value of Chromoendoscopy and Magnification Endoscopy in the Evaluation of Duodenal Abnormalities: a Prospective, Randomized Comparison
Authors: R Kiesslich, K Mergener, C Naumann, M Hahn, M Jung, H H Koehler, B Nafe, S Kanzler, P R Galle
Journal: Endoscopy (2003)

Background and Study Aims: Endoscopic staining methods are increasingly being used to evaluate lesions in the esophagus and colon. The aim of this prospective study was to investigate chromoendoscopy and magnification endoscopy for the evaluation of mucosal lesions in the duodenum. Patients and Methods: Consecutive patients were randomly assigned to undergo conventional endoscopy without staining (group A) or intravital staining of the duodenal mucosa with indigo carmine and evaluation with a conventional video endoscope (group B) or a magnification endoscope (group C). Visible lesions were characterized before and after staining, and biopsies were taken for histological assessment. Results: A total of 118 patients was examined. Chromoendoscopy detected significantly more lesions in the duodenal bulb (98 vs. 28; P = 0.0042) in more patients (29 vs. 15; P = 0.0025) compared with conventional endoscopy (group A). After mucosal staining, there was no difference between video endoscopy and magnification endoscopy with regard to the number or extent of the lesions identified. Significantly more targeted biopsies were possible after intravital staining. The most commonly identified lesions on targeted biopsies included (staining/control groups): gastric metaplasia (14/3), hyperplastic Brunner’s glands (6/3), inflammatory changes (7/6), villous atrophy (1/3), adenoma (1/0). Conclusions: Intravital staining of the duodenum with indigo carmine may be useful for detecting mucosal abnormalities, delineating their extent, and allowing targeted biopsies. Magnification endoscopy, when used in addition to chromoendoscopy, does not appear to further increase the diagnostic yield for detecting duodenal abnormalities.
Abstract P2-05-26: Focal adhesion kinase is required for efficient tumor-induced osteoclastogenesis via control of macrophage colony stimulating factor expression
Authors: K Landon, GA Howe, H Zhao, CL Addison
Journal: Cancer Research (2016)

Abstract Breast cancer most commonly metastasizes to bone where metastases cause the potentiation of the vicious cycle. During this process, breast cancer bone metastases inhibit osteoblasts from forming new bone, while also activating osteoclasts to degrade bone. This in turn causes release of bone-matrix bound growth factors which propagate tumor growth. The overall net bone destruction can lead to significant adverse clinical consequences for patients including fractures or substantial pain. While agents such as bisphosphonates or the monoclonal antibody to RANKL denosumab, both of which inhibit the osteolytic activity of osteoclasts, are currently used in breast cancer bone metastatic patients to alleviate these adverse clinical outcomes, they have not been associated with increased patient survival. Given the lack of successful treatments for bone metastases providing survival advantages, we sought to evaluate the role of focal adhesion kinase (FAK), a novel therapeutic target, in breast cancer mediated osteolysis. FAK is a non-receptor tyrosine kinase that regulates many pathways that contribute to enhanced tumor progression and metastasis. FAK is also expressed in all the cell types involved in the vicious cycle. We thus hypothesized that FAK plays an important role in breast tumor-induced osteolysis and that its inhibition would lead to restoration of bone homeostasis, in addition to inhibition of tumor progression. Using in vitro siRNA-targeted depletion of FAK in breast cancer tumor cell lines, we found that production of numerous soluble growth factors, many of which are known contributors to osteoclastogenesis, was inhibited. We confirmed that FAK regulates the expression of the osteoclastogenic factor macrophage colony stimulating factor in breast cancer cell lines. Further, using conditioned media from FAK expressing versus depleted breast cancer tumor cells in osteoclastogenesis assays, we show that FAK-depletion results in impaired osteoclastogenesis. These data suggest that in addition to its proven direct anti-tumor effects, inhibition of FAK may also result in therapeutic blockade of bone degradation. Citation Format: Landon K, Howe GA, Zhao H, Addison CL. Focal adhesion kinase is required for efficient tumor-induced osteoclastogenesis via control of macrophage colony stimulating factor expression. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-05-26.
Chemotherapy of Tumors in Rats. I. The Treatment of Sarcoma 231 in the King a Rat with 2,4,6-Triethylenimino-S-Triazine and Related Products&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn4"&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/xref&gt;
Authors: M. L. Crossley, J. B. Allison, W. W. Wainio, J. B. Muenzen
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Chemotherapy of Tumors in Rats. I. The Treatment of Sarcoma 231 in the King a Rat with 2,4,6-Triethylenimino-S-Triazine and Related Products Get access M. L. Crossley, M. L. Crossley Bureau of Biological Research, Rutgers University, New Brunswick, N. J. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. B. Allison, J. B. Allison Bureau of Biological Research, Rutgers University, New Brunswick, N. J. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. W. Wainio, W. W. Wainio Bureau of Biological Research, Rutgers University, New Brunswick, N. J. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. B. Muenzen J. B. Muenzen Bureau of Biological Research, Rutgers University, New Brunswick, N. J. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 2, October 1951, Pages 305–321, https://doi.org/10.1093/jnci/12.2.305 Published: 01 October 1951 Article history Received: 01 May 1951 Published: 01 October 1951
ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging
Authors: Chenggen Qian, Yulei Chen, Sha Zhu, Jicheng Yu, Lei Zhang, Peijian Feng, Xin Tang, Quanyin Hu, Wujin Sun, Yue Lu, Xuanzhong Xiao, Qun-Dong Shen, Zhen Gu
Journal: Theranostics (2016)

Stimuli-responsive and imaging-guided drug delivery systems hold vast promise for enhancement of therapeutic efficacy.Here we report an adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging.We demonstrate that the conjugated polymeric nanocarriers functionalized with phenylboronic acid tags on surface as binding sites for ATP could be converted to the water-soluble conjugated polyelectrolytes in an ATP-rich environment, which promotes the disassembly of the drug carrier and subsequent release of the cargo.In vivo studies validate that this formulation exhibits promising capability for inhibition of tumor growth.We also evaluate the metabolism process by monitoring the fluorescence signal of the conjugated polymer through the in vivo NIR imaging.
Magnetic Resonance Imaging
Authors: Robert R. Edelman, Steven Warach
Journal: New England Journal of Medicine (1993)

Musculoskeletal SystemMRI is widely used to assist in the diagnosis of joint injuries, bone marrow disorders, soft-tissue tumors, and other musculoskeletal abnormalities. Fibrocartilage and ligaments normally appear dark because of a paucity of mobile protons61. In the knee, MRI has a reported sensitivity of 75 to 100 percent for the identification of meniscal tears, as indicated by an increased signal intensity in the fibrocartilaginous meniscus that extends to an articular surface (Figure 6A). MRI has largely supplanted arthrography62,63. Meniscal degeneration not seen at arthroscopy is detected as an increase in intrameniscal signal intensity; this finding is . . .
Amsacrine (AMSA)--a clinical review.
Authors: A C Louie, B F Issell
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.4.562 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3884748 Amsacrine (AMSA)--a clinical review. A C LouiexA C LouieSearch for articles by this author , B F IssellxB F IssellSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.4.562 First Page PDF © 1985 by American Society of Clinical Oncology
Psychiatric training for the primary care obstetrician-gynecologist resident
Authors: P D Boekelheide
Journal: American Journal of Psychiatry (1978)

The author describes a model for the psychiatric training of obstetrics-gynecology house staff members who serve as primary care physicians for women. By integrating psychiatric skills with specialty training, the psychiatrist can enhance continuity of patient care for the resident during his transition to the role of primary care obstetrician-gynecologist.
Locoregional treatment for advanced biliary tract cancer (aBTC): evaluation of efficacy and safety
Authors: F. Battaglin, V. Vaccaro, F. Bergamo, C. Vivaldi, G. Brandi, S. Cereda, M. Russano, E. Vasile, F. Leone, M. Milella, L. Fornaro, G. Aprile, C. Aliberti, V.A. Marsico
Journal: Annals of Oncology (2015)
Introduction of U-100 insulin.
Authors: C Hardwick, A Bloom, H Keen, P J Watkins
Journal: BMJ (1979)

Obstetric anaesthetic and analgesic services in Wales SIR,-We agree with Dr D J Bowen and his colleagues (20 October, p 1002) that epidural analgesia should be available in every consultant obstetric unit as part of the pain relief service.However, there are considerable logistic difficulties to overcome in imple- menting this policy, such as the size and location of the unit and, not least, a shortage of trained anaesthetists.Unless the service can be safely offered mortality and morbidity are inevitable.It will take time to achieve this aim and our survey in Wales showed that the present deficiencies are substantial.We believed that our suggestions might go some way towards improving the situation.Dr Bowen and his colleagues are puzzled because we stated that there were few medical indications for epidural block and feel that breech deliveries, pre-eclamptic toxaemia, forceps deliveries, etc, are indications.However, there are no controlled trials to support their views.
Care Quality Commission does not take into account what really matters to patients
Authors: Hendrik J Beerstecher
Journal: BMJ (2016)

McCarthy’s list of “qualities” that the Care Quality Commission (CQC) takes into account does not include access.1 What good are cleaning schedules, audits, and drugs policies if patients cannot access the doctor in the first place? What good are wordy entries in the records if there is no time for patients to bring their concerns to their doctor? How have CQC inspections changed …