tbuckley/cabot-search huggingface dataset:
Ricolinostat (ACY-1215), a Selective HDAC6 Inhibitor, in Combination with Lenalidomide and Dexamethasone: Results of a Phase 1b Trial in Relapsed and Relapsed Refractory Multiple Myeloma
Authors: Andrew J Yee, Peter M. Voorhees, William Bensinger, Jesus G. Berdeja, Jeffrey G Supko, Paul G. Richardson, David Tamang, Simon S Jones, Gretchen Patrick, Catherine Wheeler, Noopur Raje
Journal: Blood (2014)
Council of Europe tackles drug industry’s “less noble” side
Authors: Rory Watson
Journal: BMJ (2015)

Parliamentarians from 47 European countries have overwhelmingly given their backing to moves for more openness in drug companies’ relationships with the health sector. In particular, they want the companies to make all links with the sector publicly available and to disclose the real costs of researching and developing new medicines.

The demands were contained in a resolution adopted by the Council of Europe’s parliamentary assembly on 29 September and directed at national governments. Although not legally binding, the resolution carries political and moral weight, as it was approved by nationally elected politicians across the continent by 118 votes to eight, with just seven abstentions.

Liliane Maury Pasquier, a Swiss socialist MP …
Abstract 1429: Contribution of membrane-bound carboxypeptidase M to tumor growth and metastasis by regulating epithelial mesenchymal transition in esophageal squamous carcinoma
Authors: Yuji Kudo, Junki Fukuda, Ritsuko Harigai, Kazunori Kato
Journal: Cancer Research (2015)

Abstract Carboxypeptidase M (CPM) is a membrane-bound exopeptidase that recognizes the arginine (Arg) and lysine (Lys) residues in a C-terminal of polypeptide chain or protein. The cleavage of some soluble factors such as SDF-1 and EGF by CPM leads to the alteration of binding affinity to their receptors. In this study, we examined the properties of CPM for tumor growth and metastasis in human esophageal carcinoma cells. In order to investigate the expression of CPM on human tumor cells, we established the monoclonal antibody specific for human CPM and found the constitutive expression of CPM on various human carcinomas by flow cytometry and confocal laser microscopy. Treatment of cancer cells with EMT-mediated cytokines, including TGF-beta, IL-6 and OSM, increased CPM expression on their cell surface followed by enhancement of cell migration and change of cell shapes from epithelial to mesenchymal type. Silencing CPM expression by small interfering RNA (siRNA) specific for CPM in esophageal and breast carcinoma cells were confirmed by flow cytometry. We found that CPM-silenced carcinoma exhibited reduced cell proliferation not only in 2D culture flask but also in 3D spheroid culture plate. Importantly, the treatment of siRNA for CPM inhibited the expression of EMT-related genes such as snail and slug which are important for cancer motility. Consistently, we found that CPM-silenced carcinoma exhibited reduced motility of cell in wound healing assay. Taken together, these data indicate that CPM contributes to cell growth and EMT and might be a therapeutic target in esophageal carcinoma. Citation Format: Yuji Kudo, Junki Fukuda, Ritsuko Harigai, Kazunori Kato. Contribution of membrane-bound carboxypeptidase M to tumor growth and metastasis by regulating epithelial mesenchymal transition in esophageal squamous carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1429. doi:10.1158/1538-7445.AM2015-1429
UK anaesthetist workforce is expanding too slowly, warn experts
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The rate at which consultant anaesthetists are joining the NHS workforce needs to double to meet growing demand and ensure that safe care of patients is maintained, the Royal College of Anaesthetists has said in a new report.

On 12 June the college published its Medical Workforce Census Report 2015 ,1 in which it made stark warnings about gaps in rotas, vacancies, and the ageing workforce.

For the report the college gathered data from every anaesthetic department across the United Kingdom and found that in 2015 there were 7422 consultants and 2033 staff and associate specialist (SAS) and trust grade doctors. The data showed that the total number of consultants …
Successful treatment of systemic juvenile xanthogranulomatosis with cytarabine and 2‐chlorodeoxyadenosine: case report and review of the literature
Authors: L. Maintz, J. Wenzel, M. Irnich, H. Reinhard, T. Bieber
Journal: British Journal of Dermatology (2016)

The non‐Langerhans cell histiocytosis (LCH) juvenile xanthogranulomatosis (JXG) is usually a benign disease limited to the skin. Only a few cases of systemic disease with at least two affected organs and lethal outcomes have been reported to date. Treatment is controversial and no standard protocol is available. We report the rare case of a 22‐month‐old boy presenting multiple erythematous brownish papules of the head, trunk and legs, which had developed starting from his 6th month of life. Additional symptoms were delayed psychomotor development, hydrocephalus and hepatosplenomegaly. Further diagnostics revealed a systemic JXG with involvement of the skin, central nervous system, liver and spleen. The patient did not respond to initial therapy with prednisone and vinblastine according to protocol III for LCH. However, further therapy with cytarabine and 2‐chlorodeoxyadenosine followed by a consolidation phase with 2‐chlorodeoxyadenosine alone was successful and the patient is in his 4th year of remission. We provide a comprehensive review of the reported cases of systemic JXG to date.
Acute graft-versus-host disease prophylaxis with methotrexate and cyclosporine after busulfan and cyclophosphamide in patients with hematologic malignancies
Authors: A von Bueltzingsloewen, R Belanger, C Perreault, Y Bonny, DC Roy, Y Lalonde, J Boileau, J Kassis, R Lavallee, M Lacombe
Journal: Blood (1993)
WR-2721 protects against the hematologic toxicity of cyclophosphamide.
Authors: T L Phillips
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.4.458 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3007682 WR-2721 protects against the hematologic toxicity of cyclophosphamide. T L PhillipsxT L PhillipsSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.4.458 PDF "WR-2721 protects against the hematologic toxicity of cyclophosphamide.." Journal of Clinical Oncology, 4(4), p. 458© 1986 by American Society of Clinical Oncology
Serum Haptoglobin Type in Females With Genital Cancer
Authors: Atena Miluničová, Anna Jandová, Vladimir Škoda
Journal: JNCI Journal of the National Cancer Institute (1969)

The distribution of haptoglobin types was studied in 291 females with genital cancer and in 170 females with precancerous or benign changes of endometrium. The frequency of haptoglobin types in neither group differed from normal values. No aberrations in frequency of haptoglobin types depending on site or type of cancer were observed. The distribution of haptoglobin types in our patients showed no correlation with other genetically determined characters (blood group ABO, Rh/Hr genotype, or serum group Gm) studied simultaneously with haptoglobins in our series.
Case 38-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Murray L. Janower, Gerald Nash
Journal: New England Journal of Medicine (1972)

PRESENTATION OF CASEA 42-year-old man was admitted to the hospital because of dyspnea.He had been in good health until three months previously, when he began to experience postprandial epigastric distress associated with anorexia and a loss of 4 kg in weight. Seven weeks before admission he noticed several nontender lumps on the left side of the neck, and two weeks later he was admitted to the hospital. Physical examination revealed a firm, nontender lymph node, 1.5 by 2 cm, in the left supraclavicular region, surrounded by a cluster of firm 1-cm nodes. The lungs and heart were normal, . . .
Dichloromethotrexate--a critical reassessment.
Authors: P J O'Dwyer, B Leyland-Jones, M T Alonso, M Eisenberger, D F Hoth
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.8.1148 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4020413 Dichloromethotrexate--a critical reassessment. P J O'DwyerxP J O'DwyerSearch for articles by this author , B Leyland-JonesxB Leyland-JonesSearch for articles by this author , M T AlonsoxM T AlonsoSearch for articles by this author , M EisenbergerxM EisenbergerSearch for articles by this author , D F HothxD F HothSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.8.1148 First Page PDF © 1985 by American Society of Clinical Oncology
Cancer Registries Underestimate both the Type of Disease and also Number of Cases due to Pollution
Authors: A. Adovasio, E. Aitini, M. Ceppi, M. Bruzzone, B. Pisanelli, C. Oliani, E. Patruno, F. Adami, R. Ridolfi, P. Gentilini, G. Comella, B. Castagneto, S. Barni, R. Labianca, S. Crispino, G. Porcile, V. Gennaro
Journal: Annals of Oncology (2015)
Society for immunotherapy of cancer (SITC) statement on the proposed changes to the common rule
Authors: Howard L. Kaufman, Lisa H. Butterfield, Pierre G. Coulie, Sandra Demaria, Robert L. Ferris, Jérôme Galon, Samir N. Khleif, Ira Mellman, Pamela S. Ohashi, Willem W. Overwijk, Suzanne L. Topalian, Francesco M. Marincola
Journal: Journal for ImmunoTherapy of Cancer (2016)

The Common Rule is a set of ethical principles that provide guidance on the management of human subjects taking part in biomedical and behavioral research in the United States. The elements of the Common Rule were initially developed in 1981 following a revision of the Declaration of Helsinki in 1975. Most academic facilities follow the Common Rule in the regulation of clinical trials research. Recently, the government has suggested a revision of the Common Rule to include more contemporary and streamlined oversight of clinical research. In this commentary, the leadership of the Society for Immunotherapy of Cancer (SITC) provides their opinion on this plan. While the Society recognizes the considerable contribution of clinical research in supporting progress in tumor immunotherapy and supports the need for revisions to the Common Rule, there is also some concern over certain elements which may restrict access to biospecimens and clinical data at a time when high throughput technologies, computational biology and assay standardization is allowing major advances in understanding cancer biology and providing potential predictive biomarkers of immunotherapy response. The Society values its professional commitment to patients for improving clinical outcomes with tumor immunotherapy and supports continued discussion with all stakeholders before implementing changes to the Common Rule in order to ensure maximal patient protections while promoting continued clinical research at this historic time in cancer research.
A National Study of the Prevalence of Life-Threatening Diagnoses in Patients With Chest Pain
Authors: Renee Y. Hsia, Zachariah Hale, Jeffrey A. Tabas
Journal: JAMA Internal Medicine (2016)

A National Study of the Prevalence of Life-Threatening Diagnoses in Patients With Chest PainNontraumatic chest pain is the second most frequent cause of emergency department (ED) visits among adults, resulting in more than 8 million visits annually in the United States. 1 Although the predictive value of many signs, symptoms, and diagnostic tests have been defined for life-threatening diagnoses, to our knowledge, the frequency of these diagnoses has not been determined in a nationally representative sample.The pretest probability of a given condition is critical to drive Bayesian analysis and help determine posttest probability when known predictive values of findings from the history, physical examination, and any laboratory, electrocardiographic, or radiologic testing are applied.Methods | We analyzed the National Hospital Ambulatory Medical Care Survey database, a national probability sample of visits to nonfederal, general, acute care hospitals in the United States conducted by the National Center for Health Statistics. 2 We included all ED visits from January 1, 2005, to December 31, 2011, for adults 18 years and older with the chief concern of nontraumatic chest pain.Data analysis was conducted from September 22, 2014, to September 30, 2015.We calculated the overall frequency of each diagnosis as a percentage of all included visits and for age-based subgroups.We identified 6 life-threatening conditions that are traditionally taught to be considered in patients who present with chest pain: acute coronary syndrome, aortic dissection, pulmonary embolism, tension pneumothorax, esophageal rupture, and perforated peptic ulcer. 3,4 The University of California, San Francisco, Institutional Review Board waived review of this study.Patient data from the National Hospital Ambulatory Medical Care Survey database were deidentified.Results | We analyzed 10 907 patient records, representing 42 579 676 patient visits to the ED with a primary symptom of chest pain; these visits represented 4.7% of all sampled ED visits.Table 1 provides descriptive characteristics and weighted percentages of these visits.Most patients were aged 18 to 64 years (8215 [75.6%]), female (5685 [52.7%]), non-Hispanic white (6904 [64.5%]), and treated in an urban area (9519 [84.4%]).Private insurance, Medicare, and Medicaid rates were 45.1% (n = 4914), 13.6% (n = 1443), and 18.8% (n = 2132), respectively.In terms of visit disposition, Table 2. Sources and Content of Information on Safe Storage and Proper Disposal of Opioid Medications Receipt of Information Weighted %, (SE) [No.] a Safe Storage
The Treatment of Pneumococcic Pneumonia in the Adult
Authors: M F COLLEN
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Arthroscopic Partial Meniscectomy for Degenerative Meniscal Tear
Authors: David S Jevsevar, Adolph J Yates, James O Sanders
Journal: New England Journal of Medicine (2014)

Dr. Stuart reports receiving consulting fees and royalties from Arthrex and Stryker, and receiving research funding from Stryker; and Dr. Levy, receiving consulting fees and royalties from Arthrex and VOT Solutions, and receiving research funding from Arthrex, Biomet, and Stryker. No other potential conflict of interest relevant to this letter was reported.
CR-04HISTORY BEFORE DIAGNOSIS IN CHILDHOOD CRANIOPHARYNGIOMA: ASSOCIATIONS WITH INITIAL PRESENTATION AND LONG-TERM PROGNOSIS
Authors: Anika Hoffmann, Svenja Boekhoff, Ursel Gebhardt, Anthe S. Sterkenburg, Anna M. Daubenbüchel, Maria Eveslage, Hermann L. Müller
Journal: Neuro-Oncology (2016)

OBJECTIVE: Childhood craniopharyngiomas (CP) are often diagnosed after long duration of history (DOH).Tumor size, hypothalamic involvement (HI), and obesity are associated with reduced overall survival (OS) and functional capacity (FC).The effect of DOH and specific symptoms in history on
Preferred Animal Model in Tobacco-Inhalation Studies
Authors: F. Homburger, M.D., P. Bernfeld, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Preferred Animal Model in Tobacco-Inhalation Studies Get access F. Homburger, M.D., F. Homburger, M.D. Director and President Research Bio-Research Institute, Inc.380 Green Street Cambridge, Massachusetts 02139 Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Bernfeld, Ph.D. P. Bernfeld, Ph.D. Senior Vice President, Director Research Bio-Research Institute, Inc.380 Green Street Cambridge, Massachusetts 02139 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 75, Issue 2, August 1985, Page 393, https://doi.org/10.1093/jnci/75.2.393 Published: 01 August 1985
A New Ultrasonic Probe for Endosonographic Imaging of the Upper GI Tract
Authors: T Rösch, M Classen
Journal: Endoscopy (1990)

A new ultrasonic probe (7.5 MHz, diameter 3.7 mm) was used in vitro in 3 gastric resection specimens and in vivo in 12 patients in an attempt to visualize normal and pathological wall structure of the esophagus, stomach and duodenum via the working channel of a gastroscope, and of the biliary tract via the percutaneous approach. In 5 of these patients conventional endosonography was performed. The probe visualizes the normal layer structure and pathological lesions of the upper GI-tract wall, since it can be accurately positioned at the structure of interest under visual control; water is instilled into the hollow organs to improve transmission of the ultrasound beam. Intra- and transmural changes such as blood vessels in the wall of the esophagus and stomach in portal hypertension, or gastric and esophageal tumors were demonstrated. The important advantage of the probe is that it can be used in stenosed or narrowed hollow organs, where conventional endosonography fails. However, the depth of penetration of the ultrasonic beam (10-15 mm) and circumferential imaging of the gastric wall are still inferior to those of conventional endoscopic ultrasound. As the focus distance of the ultrasound probe to the biliary ducts is too small, visualization of the biliary system is incomplete. Technical improvements could make this new probe an irreplacable diagnostic tool in the future.
Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias
Authors: K Wang, M Sanchez-Martin, X Wang, K M Knapp, R Koche, L Vu, M K Nahas, J He, M Hadler, E M Stein, M S Tallman, A L Donahue, G M Frampton, D Lipson, S Roels, P J Stephens, E M Sanford, T Brennan, G A Otto, R Yelensky, V A Miller, M G Kharas, R L Levine, A Ferrando, S A Armstrong, A V Krivtsov
Journal: Leukemia (2016)
Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets
Authors: Anton Bespalov, Thomas Steckler, Bruce Altevogt, Elena Koustova, Phil Skolnick, Daniel Deaver, Mark J. Millan, Jesper F. Bastlund, Dario Doller, Jeffrey Witkin, Paul Moser, Patricio O'Donnell, Ulrich Ebert, Mark A. Geyer, Eric Prinssen, Theresa Ballard, Malcolm Macleod
Journal: Nature Reviews Drug Discovery (2016)
Psychiatric training and practice in the People's Republic of China
Authors: P D Walls, L H Walls, D G Langsley
Journal: American Journal of Psychiatry (1975)

Improved political relations between the United States and the People's Republic of China have led to closer contact in many areas. The authors trace the development of psychiatric training and practice in China with emphasis on the years after 1949. Since then, China has expanded psychiatric services to meet the needs of a vast population and has developed a theoretical approach to psychiatry that emphasizes sociopolitical factors. Additional information given to the authors in 1973 by psychiatrists in Nanking and Shanghai is presented and correlated with reports by other recent visitors to the People's Republic of China.
Genetics of Ocular-Tumor Development in Fishes (Preliminary Report)&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Myron Gordon
Journal: JNCI Journal of the National Cancer Institute (1946)

Journal Article Genetics of Ocular-Tumor Development in Fishes (Preliminary Report) Get access Myron Gordon Myron Gordon research associate in genetics New York Aquarium, New York Zoological Society Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 2, October 1946, Pages 87–92, https://doi.org/10.1093/jnci/7.2.87 Published: 01 October 1946 Article history Received: 12 September 1946 Published: 01 October 1946
Development of Bacterial Resistance to Antibiotics
Authors: S P HALBERT
Journal: JAMA (2022)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal