tbuckley/cabot-search huggingface dataset:
Abstract P6-09-01: Breast Cancer Incidence and Hormonal Infertility Treatments: A Systematic Review of Population Studies
Authors: A Gennari, M Costa, M Puntoni, A De Censi, M D'Amico, P. Bruzzi
Journal: Cancer Research (2010)

Abstract Background: With the increasing practice of hormonal infertility treatments in infertile women, both for ovulation induction in anovulatory women and for ovarian hyperstimulation in assisted reproductive technologies, concerns have been raised about the long-term effects of such practice on the subsequent risk of breast cancer. Sterility itself is an independent risk factor, though its effect is not yet clear. In the past years, a number of population-based studies has investigated the possible association between breast cancer incidence and infertility treatments, with inconsistent results. With these premises, we performed a pooled analysis of the association between infertility treatments by any kind of hormonal manipulation and breast cancer incidence, based on published data. Methods: Population cohort studies, evaluating the association between BC incidence and hormonal infertility treatments were identified by MEDLINE search. Standardised Incidence Ratios (SIRs) were pooled across the studies by inverse variance weighting. Subgroup analyses were performed according to the following covariates: lenght of follow up (&amp;lt; 10 yrs vs ≥10 yrs), type of hormonal therapy (clomiphene vs gonadotropins) and type of control group (population based on internal control, ie infertile women). All statistical tests were two-sided. Results: Thirteen eligible cohort studies, including 364.342 women were identified and retrieved. Data on breast cancer incidence and type of fertility treatments were available for all studies. Overall hormonal infertility treatments were associated with a 15% increase in the incidence of breast cancer as compared with untreated women (SIR 1.15, CI 1.09-1.21; p &amp;lt; 0.0001). Breast cancer risk was significantly higher in clomiphene treated women (SIR 1.21; 95%CI 1.10-1.32) than in gonadotropins users (SIR 1.04; 95%CI 0.91-1.20, p for interaction &amp;lt; 0.05). The increase in breast cancer incidence seems to be dependent on the length of follow up (SIR 1.05; 95%CI 0.96-1.14 for &amp;lt;10 yrs versus 1.23; 95%CI 1.16-1.31 for ≥10yrs, p for interaction = 0.03). In the subset of cohort studies using population based estimates as controls, hormonal infertility treatment was associated with an increase in breast cancer risk (SIR 1.22; 95% CI 1.15-1.30); in studies with internal controls, i.e. cohorts of untreated infertile women, a similar breast cancer risk was observed (SIR 1.03; 95%CI 0.93-1.13; p for interaction = 0.09). Conclusions: Overall hormonal infertility treatments are associated with a significant increase in breast cancer incidence. This increase is mainly observed with clomiphene administration, whereas gonadotropins seem not to affect breast cancer risk. Finally, subset analyses according to type of controls suggest that the observed increased risk may be due to the infertility condition itself. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-09-01.
Surviving the Perfect Storm: An RVU-Based Model to Evaluate the Continuing Impact of MMA on the Practice of Oncology
Authors: David M. Dunning, Thomas A. Paivanas
Journal: Journal of the National Comprehensive Cancer Network (2006)

The Resource-Based Relative Value Scale (RBRVS) system instituted by Centers for Medicare and Medicaid Services has lead to the implementation of a new financial analysis paradigm based on relative value units (RVUs). RVU-based financial tools have great potential to allow in-depth analysis of all components of the cancer care delivery system. Because all medical oncology practices must become conversant in RVU terminology and methodology, RVU-based financial tools will allow standardization and benchmarking for intra- and interpractice comparisons. Understanding this approach is essential for sound business management. The emotional and financial pressures facing the medical oncologist in private practice are enormous, with no real relief in sight. The complexity of managing the business of private practice oncology rivals that of managing the complexity of cancer care. With anticipated reductions in total net revenue per clinical treatment protocol per course of care, funds available for providers and their practices will be severely reduced. Only those practices with superlative RVU-based cost and revenue accounting systems will be able to prospectively and efficiently manage their businesses. Clearly, management of the Oncology Practice Econometric Model (OPEM) expense RVU or similar RVU-based data will be required for survival. The purpose of this article is to explore an RVU-based model to analyze the professional, infusion, and therapeutic components of contemporary cancer care.
Effects of Thyroxine Supplementation on Neurologic Development in Infants Born at Less Than 30 Weeks' Gestation
Authors: Aleid G. van Wassenaer, Joke H. Kok, Jan J.M. de Vijlder, Judy M. Briët, Bert J. Smit, Pieter Tamminga, Anneloes van Baar, Friedo W. Dekker, Thomas Vulsma
Journal: New England Journal of Medicine (1997)

Premature infants who have transient hypothyroxinemia in the first weeks of life may have developmental delay and neurologic dysfunction. Whether thyroxine treatment during this period results in improved developmental outcomes is not known.
SP0057 Stromal cell: Leukocyte interactions in early arthritis
Authors: A. Filer
Journal: Annals of the Rheumatic Diseases (2013)

Tissue fibroblasts are not passive players in the initiation and resolution of inflammation: They act as innate immune sentinels, and engage in critical soluble and contact mediated interactions with both tissue resident and recruited inflammatory leukocyte subpopulations. They are now known to have active roles in determining the switches governing progression from acute to chronic inflammation, and also those governing resolution or the progression to chronic, persistent inflammation. The "switch to resolution" is an important signal that permits tissue repair to take place and enables immune cells to return to draining lymphoid nodes in order for immunological memory to become established. However in RA, certain fibroblast subpopulations become persistently activated and contribute to the inappropriate recruitment and retention of leukocytes in a site or organ-dependent manner, leading to tissue and site specific initiation and subsequent relapse of chronic persistent inflammatory disease; effectively a "switch to persistence". This talk will review the field of stromal cell: leukocyte interactions, examining recent data from work with early arthritis fibroblasts and potential for therapeutic targeting. <h3>Disclosure of Interest</h3> None Declared
Diabetes Care in Health Maintenance Organizations
Authors: David L Geffner
Journal: Diabetes Care (1992)

An increasing amount of health care today is directed to the amelioration of chronic diseases for which there are no cures. Technological advances and the aging of the population have increased the costs of that care. In an attempt to control costs and increase the efficiency of health care, it is being increasingly delivered in alternate health-care systems where third-party payors influence the access, use, and quality of that care. This article traces the history of the development of alternative health-care delivery systems and describes how they attempt to deal with the tension between cost and quality in the context of the delivery of health care to people with diabetes. Systems for home health care, health education and dietary counseling, prescriptions and durable medical equipment, medical technology assessment, quality management, peer review, and cost containment in the various alternative health-care settings are described. Theoretically, the health maintenance organization offers an ideal system for delivering care that is accessible, affordable, and of good quality.
THU0532 Estrogen Upregulates Interleukin-21 Production of Clusters of Differentiation 4 Positive T Lymphocytes in Patients with Systemic Lupus Erythematosus
Authors: J. Lee, J.H. Koh, H.K. Min, J.Y. Kang, Y.S. Suh, J.-H. Lee, S.-M. Jung, J.Y. Lee, J.-M. Kim, S.-K. Kwok, J.H. Ju, K.-S. Park, H.-Y. Kim, S.-H. Park
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease in which various organs and tissues are damaged through abnormal immune responses mediated by tissue-binding autoantibodies and immune complex deposition. As the majority of SLE patients are women of child-bearing age, estrogen has been suggested to play an important role in the pathogenesis of SLE. One of the proposed roles of estrogen is to increase autoantibody production. IL-21, a common-γ chain cytokine, has been shown to be crucial in the differentiation of activated B cells into plasma cells. <h3>Objectives</h3> Based on these concepts, we investigated the effect of estrogen on the production of IL-21 by T cells and subsequent B cell activation in SLE patients. <h3>Methods</h3> Peripheral blood mononuclear cells (PBMCs) were obtained from peripheral blood of 23 SLE patients and 16 healthy controls. CD4+ T cells, non CD4+ T cells and B cells were isolated using microbeads. Isolated cells were treated with 17-β estradiol at various concentrations for 48hrs. The expression of IL-21 and its receptor was assessed by measuring the level of protein and mRNA using ELISA and RT-PCR, respectively. The level of immunoglobulin G was measured with specific ELISA. <h3>Results</h3> The expression of IL-21 and its receptor in serum, PBMCs, and CD4+ T cells were higher in the patients with SLE compared to healthy controls. Exposure of CD4+ T cells from SLE patients to 17-β estradiol leads to a dose-and time-dependent increase in the IL-21 expression. The increase was abolished in the presence of MAP kinase (MEK, p38, JNK) inhibitors. B cells of healthy controls showed an increased antibody production when they were co-cultured with estrogen treated CD4+ T cells of patients with SLE. Treatment with anti-IL-21 antibody abrogated the increased antibody production of the co-culture systems, suggesting the increase was mediated by IL-21 dependent manner. <h3>Conclusions</h3> Estrogen upregulates IL-21 expression of CD4+ T cells via MAPK dependent pathways in SLE patients, which in turn induces increased antibody production by B cells. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3160
Abstract 3641: Breaking through the ceiling: A program to significantly increase efficacy in KRAS and BRAF mutant colorectal cancer xenograft tumors whose growth is arrested by Cetuximab + irinotecan therapy
Authors: Erik Corcoran, Anthony Pennello, David Surguladze, Keren Paz, James Tonra
Journal: Cancer Research (2011)

Abstract Cetuximab has significant clinical benefits alone or in combination with irinotecan in metastatic colorectal cancer (mCRC) patients with KRAS wild type tumors, but efficacy in patients with KRAS mutant tumors has thus far been elusive. Mutant BRAF in mCRC tumors may also predict for reduced benefit with EGFR antibodies. Interestingly, in preclinical CRC models, cetuximab, alone or in combination with irinotecan, has significant efficacy in tumor models with mutant KRAS or BRAF. Here we examine if this preclinical efficacy can be significantly increased in a screen for add-on therapies that may provide clinically meaningful efficacy in mCRC patients requiring an EGFR antibody. HT-29 (BRAF mutant-V600E) and HCT-116 (KRAS mutant-G38D) cell lines were utilized as models of CRC. We screened 14 compounds that could potentially add to the effects of cetuximab+irinotecan (C+I) treatment, including inhibitors of inflammation, enzymes, receptor tyrosine kinases, HSP90, cyclins, mTOR, an ATP mimetic, activators of apoptosis and PPARγ. Of the compounds evaluated only 17-AAG (HSP90 inhibitor), everolimus(mTOR inhibitor) and DC101 (antibody targeting murine VEGFR2) significantly broke the ceiling of tumor stasis established with C+I treatment alone in both models. 17-AAG+C+I resulted in T/C% values of 14 and 32% in HCT-116 and HT-29, respectively, compared to 25 and 62% in the C+I treatment group. Follow up studies showed this benefit to be due to an additive interaction between 17-AAG and irinotecan, which was also associated with significant weight loss. Everolimus+C+I treatment resulted in a T/C% of 15 and 22% in HCT-116 and HT-29, respectively, compared to 22 and 35% in the C+I treatment group. The benefits of everolimus+C+I on the other hand required all three agents. The combination of DC101+C+I was significantly more efficacious than C+I in both models, with a T/C% of 11 and 33% in HCT-116 and HT-29, respectively, compared to 19 and 53% in C+I treatment group. In contrast to these three therapies, all other compounds evaluated did not improve the antitumor effects of C+I alone. Results demonstrate a ceiling effect in CRC models with KRAS or BRAF gene mutations that may be associated with the limited clinical benefits observed with cetuximab in patients. The fact that this ceiling can be broken with everolimus in a manner that requires cetuximab, supports the potential utility of cetuximab in these patients in a combination approach. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3641. doi:10.1158/1538-7445.AM2011-3641
PARE0001 Patient Public Involvement in Nhs. LIP Service? How Hard is IT to Have Any Impact?
Authors: C. Lim, J. Kirk, E. Edwards, B. Colaco, M. Hoffmann
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> NHS England and the Health Care act 2012 encourages patients involvement in design and delivery of targeted care. The system changes with Community led commissioning of care has brought a raft of new measures for providers and patients to negotiate. <h3>Objectives</h3> The Central Middlesex Hospital Rheumatology Support Group (CMRSG) was initially set up to benefit the psychosocial wellbeing of the patients of the Unit. It aimed to meet on a regular basis to improve the liason between the small Rheumatology Unit and the local patient population, and commit to effect positive changes. Diminishing staff and unmanaged waiting lists led to regular patient representative complaints to an unresponsive Secondary Care Trust Provider senior management. <h3>Methods</h3> The group meets monthly and provides support and advice between members, and arranges outside speakers giving motivational and/or clinically relevant informative talks. It also aims to involve patients in helping to give patients a say in the way services are delivered, and to ensure the NHS remains accountable, dynamic and responsive to their needs. <h3>Results</h3> The group has explored use of email contact with over 300 members now and over 100 by snail mail. An audit of patient preferences by survey monkey was a powerful confidentially managed tool to let management know the patients were not to be relocated and that staff who had been withdrawn were required back. Interim Locum Consultant arrangements have relieved a lot of pressure on waiting lists and temporarily improved patient safety and outcomes we believe. This group has obtained advice from experienced patient reps at Trust board level and pursued objectives via local Government Health strategy boards to effect pressure upon the Commissioning body (CCG) and the provider arm (NHS Trust). Latterly, meetings with Trust Strategy team has happened. This was because of perceived power from the group to now retain business from a run down clinic in the face of CCG expression of recommissioning with any willing provider. The aim is to support local clinic services which have been built up on a virtually single handed basis over 20 years by one Specialist consultant. <h3>Conclusions</h3> Patient groups are important for the wellbeing of patients by acting as a group towards common goals. Patients can help determine service design to improve access and outcomes. The campaign to keep the CMH Rheumatology service is still in action and we won the first stage by discovering and following the complaints mechanism which halted the decision of decommissioning on a procedural technicality. We are now moving to the next stage which will improve our Rheumatology service at CMH and look forward to work with managers in monitoring resource and demand management in some detail. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5992
Abstract 3006: A systematical view on key genetic factors affecting somatic copy number alternations in different cancers
Authors: Yudong Li, Yuan Yuan, Han Liang
Journal: Cancer Research (2012)

Abstract Along with somatic mutations and translocations, somatic copy number alternations (SCNAs) play essential roles in the development of cancers. However, it remains poorly understood what mutagenic features driving cancer SCNAs are encoded in the genome sequence and how their effects vary across different cancer types. Taking advantage of recently available the Cancer Genome Atlas (TCGA) data, we performed a systematic analysis on the effects of various genetic sequence features on cancer SCNAs. We first assessed the correlations of breakpoint density across different cancer types and found that they overall showed very strong positive correlations, but in some cases, the correlations varied from chromosome to chromosome. Next, we investigated the dependence of SCNAs on 16 sequence features and found that compared to copy number variations in human populations, SCNAs showed much weaker correlations, suggesting a stronger effect of functional selection on their observed patterns. Finally, we built integrative models to identify key features affecting different cancer SCNAs. Our study provides a systematic view how genome-wide sequence features affect cancer SCNAs and lays a foundation for identifying key SCNAs driving cancer pathogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3006. doi:1538-7445.AM2012-3006
What can and what cannot be adjusted in the movement patterns of cerebellar patients?
Authors: Patrick Haggard
Journal: Behavioral and Brain Sciences (1996)

This commentary reviews the case of a patient who could alter the coordination of her prehensile movements when removal of visual feedback reduced her kinetic tremor, but could not coordinate her hand aperture with her hand transport within a single movement. This suggests a dissociation between different subtypes of cerebellar context-response linkage, rather than a single, general association function, [THACH]
Abstract 2712: Heterogeneous nuclear ribonucleoprotein H1 confers transcription and transactivation of androgen receptor: Implications for prostate cancer progression in African American men
Authors: Yijun Yang, Dingwu Jia, Rodney Davis, Krishnarao Moparty, Raju Thomas, Krzysztof Moroz, Krishna C. Agrawal, Asim B. Abdel-Mageed
Journal: Cancer Research (2010)

Abstract Caucasian American (CA) and other ethnic minority groups. The causes of this ethnic disparity in clinical manifestation and outcome of the disease are not well understood. Here we identified, by employing a combined approach of laser capture microdissected (LCM), suppressive subtractive hybridization (SSH), and custom race-based CaP cDNA microarray on fresh specimens, selective expression of heterogeneous nuclear ribonucleoprotein H1 (hnRNPH1) in prostate tumor cells of AA men in comparison to CA men. An ethnicity-based tissue microarray (TMA) analysis revealed selective nuclear accumulation of hnRNPH1 in tumor cells compared to adjacent normal epithelium and benign prostatic hyperplasia (BPH). We also show that hnRNPH1 up-regulates transcription, physically interact with, and confers hormone-dependent (HD) and independent (HI) transactivation of androgen receptor (AR) in CaP cells. Further, our reporter, ChIP, and EMSA analyses demonstrate hnRNPH1 binds to androgen response elements (AREs) on promoter and enhancer element of PSA gene and the ligand binding domain-encoding exons D, E and H of the AR gene, suggesting it acts as a coactivator of AR in CaP cells. Interestingly, siRNA silencing of hnRNPH1caused growth arrest and enhanced cytotoxicty of Bicalutamide in AR-expressing CaP cells. These findings support a model in which hnRNP H1 is an exclusive auxiliary factor for AR to elicit androgen-specific transcriptional regulation of androgen-regulated genes and drug resistance. Given heterogeneity of CaP and that AR is implicated in androgen independent progression of CaP, the results demonstrate a previously uncharacterized mechanism for AR-hnRNPH1 axis in disease progression and hormone refractory via enhancing HD and HI mediated transcription and transactivation of AR in a subset of prostate tumor cells in AA men. The results not only reveal racial differences in the biology of CaP, but also provide, for the first time, a new frontier for the development of diagnostic, preventive, and/or targeted therapeutic strategies to circumvent disease progression in AA men. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2712.
LONG-TERM CLINICAL IMPLICATIONS OF RESIDUAL PULMONARY VASCULAR OBSTRUCTION AFTER PULMONARY EMBOLISM: A VENTILATION-PERFUSION LUNG SCAN FOLLOW-UP STUDY AT TWO TIMEPOINTS
Authors: Romain Chopard, Bruno Genet, Marc Badoz, Fiona Ecarnot, Benjamin Bonnet, Marie-France Seronde, Francois Schiele, Nicolas Meneveau
Journal: Journal of the American College of Cardiology (2016)
Potential utility of double-balloon enteroscopy for the diagnosis and evaluation of gastrointestinally mediated allergy
Authors: Martin Raithel, Heinz Albrecht, Ralf Rieker, Alexander Hagel, Markus Neurath
Journal: Endoscopy (2014)

A 41-year-old man was admitted because of postprandial abdominal pain, diarrhea, headache, and reduced physical activity. After extensive investigations to clarify the differential diagnosis, all of which produced unremarkable findings, rectal double-balloon enteroscopy (rDBE) was performed with the newly available double-ballon enteroscope EN 580-T (FujiFilm Europe, Düsseldorf, Germany). The procedure was performed with carbon dioxide insufflation, reaching a level of 160 cm above the ileocecal valve without causing significant pain.
Committee Recommends Triple Attack on Breast Cancer
Authors: N. S. Larsen
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Committee Recommends Triple Attack on Breast Cancer Get access Natalie S. Larsen Natalie S. Larsen Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 12, 16 June 1993, Pages 946–947, https://doi.org/10.1093/jnci/85.12.946 Published: 16 June 1993