tbuckley/cabot-search huggingface dataset:
Dramatic change in public attitudes towards vaccination during the 2009 influenza A(H1N1) pandemic in France
Authors: P Peretti-Watel, P Verger, J Raude, A Constant, A Gautier, C Jestin, F Beck
Journal: Eurosurveillance (2013)

We investigated the potential impact of the 2009 influenza A(H1N1) pandemic on attitudes towards vaccination among people aged 18 to 75 years and living in metropolitan France. We used data from three national telephone surveys conducted on representative samples in 2000, 2005 and 2010 (n=12,256, n=23,931, n=8,573 respectively). In France, unfavourable attitudes towards vaccination in general dramatically increased from 8.5% in 2000 and 9.6% in 2005 to 38.2% in 2010. In 2010, among respondents who held unfavourable attitudes towards vaccination, 50% mentioned specifically their opposition to the influenza A(H1N1) vaccine. The sociodemographic profile associated with these attitudes also changed greatly. In particular, unfavourable attitudes towards vaccination in general became significantly more frequent among less educated people in 2010. These attitudes were also correlated with vaccination behaviours. For example, parents who were unfavourable towards vaccination in general were more likely to report that they had at least one child who did not get the measles-mumps-rubella vaccine. As this shift in attitude may have a significant impact on future vaccination coverage, health authorities should urgently address the vaccine confidence gap.
DOES ANTIPLATELET THERAPY INCREASE THE BLEEDING EVENTS AMONG PATIENTS WITH NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANT IN REAL WORLD?
Authors: Yoji Okamoto, Satoki Fujii, Masatomo Ozaki, Mitsuru Yoshino, Noriyuki Ohashi, Hiroshi Tasaka, Kazushige Kadota, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2015)
Changing the Intraoperative Nodal Status of a Breast Cancer Patient Using Freehand SPECT for Sentinel Lymph Node Biopsy
Authors: Christina Bluemel, Andreas Schnelzer, Alexandra Ehlerding, Klemens Scheidhauer, Marion Kiechle
Journal: Clinical Nuclear Medicine (2013)

Radio-guided sentinel lymph node biopsy in early-stage breast cancer is standard of care. Freehand SPECT is a system for intraoperative visualization of radioactivity in the body. It generates a 3-dimensional image of the radioactivity distribution complementing the acoustic information of the gamma probe by providing depth and radioactive uptake information. In the reported case, freehand SPECT was used in a breast cancer patient as a control method after conventional sentinel lymph node biopsy. Freehand SPECT identified an additional lymph node, changing the original stage from pN1(mic) (micrometastasis) to pN1a (nodal positive), resulting in an axillary lymph node dissection.
Comparative Reactivities of Aortic Strips from Hypertensive and Normotensive Rats to Epinephrine and Levarterenol
Authors: SAMUEL MALLOV
Journal: Circulation Research (1959)

Rats were rendered hypertensive by two different technics. Isometric tensions developed by strips of aorta from these rats, when exposed to various concentrations of epinephrine and levarterenol, were compared with those developed by aortic strips from normotensive controls. Almost all of the aortic strips from the DCA-salt hypertensive rats responded with smaller contraction tensions to both pressor agents than did the corresponding control strips from the normotensive animals. The same was true for most of the strips obtained from the renal hypertensive rats. These results do not lend support to the hypothesis that vascular hyperreactivity is the basis of many forms of hypertension.
Abstract 4764: The Bromodomain inhibitors regulate long noncoding RNAs controlling glioblastoma progression
Authors: Chiara Pastori, Philip Kapranov, Clara Penas, Georges St. Laurent, Nagi Ayad, Claes Wahlestedt
Journal: Cancer Research (2015)

Abstract Bromodomain and extra-terminal domain (BET) proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule mimics of acetylated histones inhibit BET protein function and reduce expression of several oncogenes required for glioblastoma (GBM) progression. However, the mechanism through which BET protein inhibition reduces GBM growth is not completely understood. Long noncoding RNAs (lncRNAs) are important epigenetic regulators with critical roles in cancer initiation and malignant progression but mechanistic insight into their expression and regulation by bromodomain inhibitors remains elusive. In this study we utilized single molecule sequencing (SMS) to comprehensively profile lncRNAs differentially expressed in GBM and we identified a subset of GBM-specific lncRNAs whose expression is regulated by BET proteins. Treatment of GBM cells with the BET protein inhibitor I-BET151 reduced levels of the tumor-promoting lncRNA HOTAIR and restored the expression of several other GBM-down-regulated lncRNAs. Conversely, overexpression of HOTAIR in conjunction with I-BET treatment rescues the antiproliferative activity of I-BET151. Moreover, chromatin immunoprecipitation analysis demonstrated binding of Brd4 to the HOTAIR promoter suggesting that BET proteins can directly regulate lncRNA expression. Our data unravel a previously unappreciated mechanism through which BET proteins control tumor growth of glioblastoma cells and suggest that lncRNA networks may, in part, mediate the anti-proliferative effects of many epigenetic inhibitors currently in clinical trials for cancer and other diseases. Note: This abstract was not presented at the meeting. Citation Format: Chiara Pastori, Philip Kapranov, Clara Penas, Georges St.Laurent,Nagi Ayad, Claes Wahlestedt. The Bromodomain inhibitors regulate long noncoding RNAs controlling glioblastoma progression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4764. doi:10.1158/1538-7445.AM2015-4764
The Influence of Pregnancy on Otosclerosis
Authors: Richard T. Barton
Journal: New England Journal of Medicine (1945)

THE relation of pregnancy to otosclerosis, the indication for abortion and the effect of abortion on the progress of the disease are topics that have rarely been discussed in the English medical literature. The literature in Europe in the last decade has been stimulated and influenced by German attempts to lay down rules for their eugenics courts to regulate this particular disease. In this country, no formal statements have been made on the subject, yet the interruption of a pregnancy complicating otosclerosis is not an infrequent procedure in hospitals.Material and MethodsAll the cases of otosclerosis at the University . . .
AB0791 Investigation of OA Progressing Factors in Prospective 5-Years Observation: Table 1.
Authors: N. Kashevarova, E. Zaytseva, A. Smirnov, O. Pushkova, N. Demin, L. Alekseeva, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Prediction of osteoarthritis (OA) course presents certain difficulties, as early diagnostics of the disease is practically absent, the data on risk factors of progressing are controversial till now. <h3>Objectives</h3> To single out the risk factors of structural knee joints OA progressing during 5-years prospective observation. <h3>Methods</h3> 5-years prospective investigation includes 110 women aged 42 - 80 with primary knee joints OA according ACR criteria, examined in 2004 – 2006 and once again in 2009 – 2011. All patients questioned, index Womac was assessed, they had radiography, ultrasound investigation (US) of knee joints, densitometry of subchonrdal regions of femoral and tibial bones at the beginning and end of observation. <h3>Results</h3> During the 5-years period of observation knee joints OA progressing (increase of X-ray stage) was noticed in 40 patients, 70 demonstrated the same stage. During the first examination of the group of patients with gonarthritis progressing the 1st radiological stage was found in 30% of patients, 2nd and 3 –d in 70%, 4th stage was not found, during the second examination in the same group in 5 years the 1-st stage was not found in anybody, 2nd and 3d were found in 62,5% and 4th almost in 40% of patients. Patients in both were comparable by age and disease duration. During the first examination patiens with progressing had more intensive pain in knees at walking 57,86±16,63 against 48,77±13,33 mm by WASH (p=0,002), higher values of BMI 33,2±6,05 against 30,51±5,63 kg/m<sup>2</sup> (p=0,021), knee jonts synovitis was more frequently found according US data 50,0% against 18,6% (p=0,002), during densitometry of subchondral regions of femoral and tibial bones a tendency was noted to increase of mineral density of bone tissue (BMD) in the region of medial condyle of the femur in all the length, which could be regarded as risk factors of knee joints OA progressing. After second examination in 5 years the growth of values of the mentioned factors was observed. Thus, BMI from 33,2±6,05 to 34,18±6,24, pain intensity from 57,86±16,63 to 67,68±21,49, knee joints synovites from 50,0% to 62,5% and BMD increase in subchondral regions of the femur in all the length from 0,7 [0,6-0,8] to 0,8 [0,5-0,9]. Basing on discriminate analysis these variables were singled out as risk factors of knee joints OA progressing (Table 1). Correctness of grouped cases: 68,1% observations were classified right. <h3>Conclusions</h3> Thus, the obtained data of 5-year long observation testify to the fact, that factors of OA progressing include: high indices of pain intensity, BMI, presence of synovitis and BMD increase in sunchondral regions of the femur in all the length. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3103
S38 TGF-Beta1 Negatively Regulates BMP4 Signalling in Human Pulmonary Artery Smooth Muscle Cells Via A Smad3-Dependent Mechanism
Authors: PD Upton, RJ Davies, T Tajsic, L Long, A Crosby, NW Morrell
Journal: Thorax (2012)

<h3>Introduction</h3> BMP4 signals via the Smad pathway to induce the expression of the ID dominant-negative basic helix-loop-helix transcription factors (ID1–4) that regulate cell differentiation. We have shown that ID induction is blunted in human pulmonary artery smooth muscle cells (HPASMCs) from pulmonary arterial hypertension (PAH) patients with mutations in the bone morphogenetic type-II receptor (BMPR-II). TGFβ1 is implicated in the pathogenesis of PAH. We therefore examined whether TGFβ1 and BMP4 signalling directly interact in HPASMCs. <h3>Methods</h3> Explant-derived HPASMCs from unaffected donors or PAH patients with identified BMPR-II mutations were studied. The transcriptional responses of ID1, ID2, PAI1 and CTGF to BMP4, TGFβ1 or co-treatment were examined by qPCR In some experiments, cells were pre-incubated with cycloheximide or pharmacological inhibitors of ALK5 (SD208), MAP kinase (U0126), TAK1 or p38 MAP kinase (SB203580). The roles of Smad2, Smad3, Smad6 and Smad7 were investigated using siRNAs. Smad-dependent transcription was examined using the BMP-responsive luciferase reporter (BRE-luc) and the TGF-responsive luciferase reporter, CAGA12-luc. Protein lysates collected at 1 and 4hrs were immunoblotted for phosphorylated and total Smads and candidate kinases. In some experiments, nuclear and cytoplasmic fractions were prepared and immunoblotted. <h3>Results</h3> BMP4 induced ID1 and ID2 expression at 1, 4 and 24h whereas TGFβ1 induced ID1/2 at 1h and repressed them at 4h and 24h. TGFβ1, but not BMP4, induced PAI1 and CTGF expression. BMP4 did not alter TGFβ1-mediated transcriptional responses. In contrast, TGFβ1 attenuated BMP4-mediated ID1/2 induction and the BRE-luc response in donor HPASMCs. Moreover, TGFβ1 abolished BMP4 responses in PAH PASMCs with BMPR-II mutations. This was reversed by the ALK5 inhibitor, SD208, but not by cycloheximide or a TAK1 inhibitor. BMP-Smad phosphorylation and nuclear translocation did not differ between co-treatment and treatment with individual ligands. Smad3 siRNA, but not Smad2, Smad6 or Smad7, reversed the inhibitory effect of TGFβ1. <h3>Conclusions</h3> TGFβ1 negatively regulates BMP4-mediated ID genes transcription by interfering with BMP-Smad signalling via Smad3, abolishing the BMP signals in cells with BMPR-II mutations. These data reinforce the notion that TGFβ1 plays a pathogenic role in PAH, via direct inhibition of the attenuated BMP response caused by BMPR-II insufficiency.
Prevention Centers Planned For U.S., France
Authors: Cori Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Prevention Centers Planned For U.S., France Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 1, 1 January 1992, Pages 12–13, https://doi.org/10.1093/jnci/84.1.12 Published: 01 January 1992
WORSENING RISK FACTORS BUT IMPROVED EVIDENCE BASED MEDICAL THERAPY IN PATIENTS UNDERGOING STRESS TESTING: INSIGHTS FROM A 220,000 PATIENT REGISTRY
Authors: Serge C. Harb, Leslie Cho, Yuping Wu, Carol Rouphael, Paul Cremer, Theresa Guy, Venu Menon, Wael Jaber
Journal: Journal of the American College of Cardiology (2016)
A Controlled Study of Ranitidine for the Prevention of Recurrent Hemorrhage from Duodenal Ulcer
Authors: Dennis M. Jensen, Susie Cheng, Thomas Kovacs, Gayle Randall, Mary Ellen Jensen, Terry Reedy, Harold Frankl, Gustavo Machicado, James Smith, Michael Silpa, Gary Van Deventer
Journal: New England Journal of Medicine (1994)

Hemorrhage is the most common complication of duodenal ulcer disease, but there is little information about the effectiveness and safety of long-term maintenance therapy with histamine H2-receptor blockers.We conducted a double-blind study in patients with endoscopically documented hemorrhage from duodenal ulcers. Patients were randomly assigned to maintenance therapy with ranitidine (150 mg at night) or placebo and were followed for up to three years. Endoscopy was performed at base line (to document that the ulcers had healed), at exit from the study, and when a patient had persistent ulcer symptoms unrelieved by antacids or had gastrointestinal bleeding. Symptomatic relapses without bleeding were treated with ranitidine; if the ulcer healed within eight weeks, the patient resumed taking the assigned study medication.The two groups were similar at entry, which usually occurred about three months after the index hemorrhage. After a mean follow-up of 61 weeks, 3 of the 32 patients treated with ranitidine had recurrent hemorrhage, as compared with 12 of the 33 given placebo (P < 0.05). Half the episodes of recurrent bleeding were asymptomatic. One patient in the ranitidine group withdrew from the study because of asymptomatic thrombocytopenia during the first month.For patients whose duodenal ulcers heal after severe hemorrhage, long-term maintenance therapy with ranitidine is safe and reduces the risk of recurrent bleeding.
Traitement des hémorragies digestives par application de poudre hémostatique par voie endoscopique: résultats d'une étude prospective multicentrique du GRAPHE réalisée en pratique courante
Authors: S Haddara, J Branche, P Bichard, Y Le Baleur, U Chaput, S Lecleire, J Jacques, J Privat, J Levy, A Charachon, B Godart, D Sautereau, V Quentin, S Leblanc, E Coron
Journal: Endoscopy (2014)

Le risque d'échec d'hémostase endoscopique par méthodes classiques (sclérose au sérum adrénaliné, clips) est d'environ 10%. En particulier, certaines conditions techniques, l'existence de troubles de l'hémostase ou le type de lésion hémorragique peuvent rendre l'hémostase endoscopique difficile. Récemment, l'utilisation d'une poudre hémostatique a permis de traiter des hémorragies digestives avec des résultats prometteurs chez l'homme dans les études pilotes. Les buts de ce travail prospectif multicentrique étaient de déterminer 1) la faisabilité de l'application de la poudre hémostatique en pratique clinique de routine, et 2) son efficacité à court et moyen terme dans différentes situations cliniques.
FLT PET/CT Is Better Than FDG PET/CT in Differentiating Benign From Malignant Pancreatobiliary Lesions
Authors: P.M. Vineeth Kumar, G.R. Verma, B.R. Mittal, Kanhaiyalal Agrawal, Rahul Gupta, Rakesh Kochhar, Virendra Singh, Lileshwar Kaman, Rajinder Singh
Journal: Clinical Nuclear Medicine (2016)

F-fluorothymidine (FLT), unlike FDG, is incorporated exclusively into DNA and is considered a specific marker of cell proliferation. The role of FLT PET/CT scan in differentiating benign from malignant pancreatobiliary tumors is unknown.Twenty-five suspected pancreatobiliary tumors on contrast-enhanced CT (CECT) scan in 23 patients were evaluated by FDG PET/CT and FLT PET/CT scans. The histopathology or fine-needle aspiration cytology was considered as criterion standard for the diagnosis. Surgeons were blinded to FLT PET/CT results. Management decision was guided by clinical and CECT scan and FDG PET/CT.Five of 23 patients had metastatic disease on CECT imaging. The remaining 18 underwent exploratory laparotomy. Two of them had synchronous lesions. Histopathology/fine-needle aspiration cytology confirmed malignancy in 17 lesions and benign disease in the remaining 8 lesions. All 8 benign lesions were negative on FLT PET/CT. Seven of the 8 benign lesions were clinically diagnosed as malignancy on CECT and FDG PET/CT. The specificity, positive predictive value, and accuracy were higher for FLT PET/CT (100%, 100%, and 92%) compared with CECT (12.5%, 70.83%, and 72%) and FDG PET/CT (12.50%, 69.57%, and 68%). However, the sensitivity of FLT PET/CT (88.24%) was similar to CECT (100%) and FDG PET/CT (94.12%).Molecular-based FLT PET/CT is a better imaging than FDG PET/CT in differentiating benign from malignant lesions in the pancreatobiliary region. It has a potential to bring down the incidence of preventable radical resection in suspected pancreatobiliary tumors.
Abstract LB-196: Treatment with anti-CD137 mAbs causes intense accumulations of liver T cells without selective antitumor immunotherapeutic effects
Authors: Juan Dubrot, Asis Palazon, Francisca Milheiro, Ivan Martinez-Forero, Ignacio Melero
Journal: Cancer Research (2010)

Abstract Discussion Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-196.
Incidentally Detected Arterial Thrombosis in 99mTc-Methylene Diphosphonate Skeletal Scintigraphy
Authors: Ankur Pruthi, Vishu Vijayant Chauhan, S A Rao, P S Choudhury
Journal: Clinical Nuclear Medicine (2013)

The association between cancer and venous thrombosis is well established. However, that between malignancy and arterial thrombosis is less well described. We herein report a 48-year-old male patient diagnosed with base of tongue carcinoma, referred for Tc-methylene diphosphonate (MDP) bone scan study to evaluate recently developed pain and numbness in his right leg while undergoing chemoradiation. Tc-MDP bone scan study revealed complete absence of radiotracer distribution in the right lower limb below the knee region. This finding was inferred to be due to avascularity in this region secondary to thrombo-embolism that was substantiated by color Doppler sonography.
FRI0093 Power doppler assessment of synovial vascularity predicts the presence of magnetic resonance imaging-proven osteitis in patients with rheumatoid arthritis
Authors: S.-Y. Kawashiri, T.S. Suzuki, A. Okada, M. Tamai, H. Nakamura, T. Origuchi, M. Uetani, K. Aoyagi, A. Kawakami
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Musculoskeletal ultrasonography (MSKUS) and magnetic resonance imaging (MRI) are known as high sensitive imaging modality toward the patients with rheumatoid arthritis (RA). Especially, the synovial vascularity determined by power Doppler (PD) assessment and osteitis proved by MRI are most important findings to classify as well as reflect the radiographic outcome of RA patients. <h3>Objectives</h3> To investigate whether PD assessment of synovial vascularity predict the presence of MRI-proven osteitis in patients with RA. <h3>Methods</h3> Twenty-seven RA patients, who fulfilled 2010 RA classification criteria and are naïve to disease-modifying antirheumatic drugs (DMARDs) including biologics or glucocorticoids, are consecutively enrolled in this studyfrom May 2010 through December 2011. Twenty-two joints from each patient including bilateralwrists and finger joints of the 1st – 5th metacarpophalangeal (MCP) joints, the 1st interpharangeal (IP) joint and the 2nd -5th proximal interpharangeal (PIP) joints were examined by both MSKUS and plain MRI. Therefore, a total of 570 joints were investigated in the present study. PD signals were graded on a semi-quantitative manner and MRI-proven osteitis was determined by RAMRI scoring (RAMRIS) technique as previously described. The Cochran-Armitage test was used to test for a trend in the prevalence of osteitis according to PD grade. <h3>Results</h3> The mean disease duration, age, DAS28-ESR, prevalence of RF and anti-cyclic citrullinated peptide antibodies (ACPA) at examination were 17 months, 60 years-old, 4.99, 81.5% and 70.4%, respectively. PD grade 1, grade 2 and grade 3 were found in 35 joints, 54 joints and 41 joints, respectively. MRI-proven osteitis was found in 61 joints. A remarkable correlation of the PD grade with the presence of osteitis was demonstrated by the Cochran-Armitage test (p&lt;0.001). <h3>Conclusions</h3> The present study may reinforce an importance of PD signals on MSKUS and MRI-proven osteitis to characterize the joint injury in patients with RA. <h3>References</h3> Kawashiri SY, et al. The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in patients with rheumatoid arthritis. Rheumatology (Oxford) 2011; 50: 962-5. Tamai M, et al. A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies. Arthritis Rheum. 2009;61:772-8. <h3>Disclosure of Interest</h3> None Declared
Mini-Sentinel and Regulatory Science — Big Data Rendered Fit and Functional
Authors: Bruce M. Psaty, Alasdair M. Breckenridge
Journal: New England Journal of Medicine (2014)

Under the leadership of the FDA and study investigators, the Mini-Sentinel project has not only transformed big medical data into a national research resource fit for purpose, but also created a collaborative research capacity for high-quality pharmacoepidemiology.