tbuckley/cabot-search huggingface dataset:
Effects of BCG and Two of Its Phenotypes on Ehrlich Tumor
Authors: R. Turcotte, M. Quevillon
Journal: JNCI Journal of the National Cancer Institute (1974)

Two phenotypes derived from 1 substrain of BCG had quite opposite effects on the early development of subcutaneous transplants of Ehrlich carcinoma in Swiss mice: Phenotype 1 enhanced and phenotype 3 inhibited, whereas the parental BCG was without any detectable immediate effect. On the other hand, the 3 bacillary preparations prolonged the survival of mice with the intraperitoneal tumor.
With Appreciation
Authors: Ram Y Gordon
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Nutcracker and jackhammer esophagus treatment: a three-case survey, including two novel cases of eosinophilic infiltration into the muscularis propria
Authors: Hiroki Sato, Manabu Takeuchi, Kazuya Takahashi, Yuichi Sato, Satoru Hashimoto, Kenichi Mizuno, Kenji Suzuki, Masaaki Kobayashi, Terasu Honma, Haruhiro Inoue, Shuji Terai
Journal: Endoscopy (2015)

Nutcracker esophagus and jackhammer esophagus are largely unknown motility disorders, also sometimes called hypertensive and hypercontractile peristalsis, respectively. There is currently no standardized diagnostic or management plan for these diseases. Here, we report on three patients with jackhammer/nutcracker esophagus who were treated with either peroral endoscopic myotomy or a systemic steroid regimen, focusing particularly on two novel presentations of nutcracker and jackhammer esophagus involving eosinophilic infiltration into the muscularis propria, and their responses to both interventions.
Development of 9&lt;italic&gt;α&lt;/italic&gt;-Fluorohydrocortisone Resistance in 9&lt;italic&gt;α&lt;/italic&gt;-Fluorohydrocortisone-Sensitive Lymphosarcoma of the Mouse&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Lampkin-Hibbard, Julia McCain
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Development of 9α-Fluorohydrocortisone Resistance in 9α-Fluorohydrocortisone-Sensitive Lymphosarcoma of the Mouse Get access Julia McCain Lampkin-Hibbard Julia McCain Lampkin-Hibbard Cancer Research Laboratory, University of Miami, Coral Gables, Florida Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 24, Issue 6, June 1960, Pages 1341–1352, https://doi.org/10.1093/jnci/24.6.1341 Published: 01 June 1960 Article history Received: 17 November 1959 Revision received: 04 January 1960 Published: 01 June 1960
Nathaniel Chapman (1780-1853) First President of the American Medical Association
Authors: N A D'Amato
Journal: JAMA (1970)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Massachusetts Medical Society
Authors: Maurice S. Segal
Journal: New England Journal of Medicine (1975)

JOSEPH TARTAKOFF, M.D.Dr. Joseph Tartakoff, the teacher, scholar, humanitarian, surgeon who marshaled the friends and staff of the Mount Auburn Hospital in the development of the presently modernized Cambridge teaching medical center, died on June 23, 1974, after a protracted and painful illness. Memorial services held at the Longy School of Music in Cambridge on June 28, 1974, and personal tributes offered by some of his colleagues reflected the passing of an extraordinary, sensitive, and brilliant man who had lived a full life in too short a time.Dr. Tartakoff left a family of scholars and scientists: his wife, . . .
PTH-283 Presentation and referral pathway for colorectal cancer patients: is national screening programme and 2 week wait making a difference?
Authors: L Douglas, K Sasapu
Journal: Gut (2015)

<h3>Introduction</h3> Colorectal cancer is the second largest cause of cancer death in the UK, and survival is significantly improved when diagnosed at an early stage; thus the call for earlier detection and faster referral. However, there are concerns that many cancers are still left undetected. This cross-sectional study aims to explore variations in the presentation and referral pathway for colorectal cancer patients in a district general hospital. <h3>Method</h3> Data from 388 histologically proven colorectal cancer patients diagnosed between 1<sup>st</sup>January 2012 and 31<sup>st</sup>December 2014 were analysed, and the method of presentation was reviewed. For patients presenting as elective admissions, their referral pathway was further analysed to establish the impact of faster referral methods, including 2 week wait and National Screening Programme. This was reviewed against the 4,950 patients referred to the trust as 2 week wait in the same time period. Finally, MDT outcomes were quantitatively analysed to explore the reasons why patients did not undergo surgical intervention for their cancer. <h3>Results</h3> Of the 388 colorectal cancer patients, 34.3% (n = 133) presented through 2 week wait, 8.7% (n = 34) were referred through National Screening; 17.3% (n = 67) elective patients presented as routine. Of all the colorectal patients 32.7% (n = 123) patients were still presenting through emergency admissions. Of the 4,950 patients who presented via 2 week wait in the 36 months analysed, only 2.7% (n = 133) had a positive cancer diagnosis. Quantitative analysis of management showed that of the 388 colorectal cancer patients, 53.4% (n = 207) underwent surgical resection as part of their management. Of the 181 patients who did not undergo surgical resection, 65.7% were due to the advanced stage of the cancer on presentation, and 21.9% were due to patient factors including co-morbidities and patient refusal. <h3>Conclusion</h3> Whilst the number of patients with colorectal cancer presenting through faster referral methods is high, the percentage of positive 2 week wait referrals is very low; and a worrying amount of patients are still presenting through emergency admissions. Furthermore, there are large amounts of patients presenting who do not undergo surgical intervention. Overall this would suggest that despite the 2 week wait and National Screening Programme, many patients are presenting late with cancer, or indeed being missed all together in the community. <h3>Disclosure of interest</h3> None Declared.
Case 7-1981
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Charles A. Boucher, John T. Fallon
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 55-year-old man was admitted to the hospital because of hemoptysis.He was well until two years earlier, when hyper-tension was found, and hydrochlorothiazide was administered. Six months before entry a routine physical examination was negative; no murmur was heard. One month before admission another routine examination by a second physician revealed a Grade 3 systolic murmur. An electrocardiogram and an x-ray film of the chest were normal. Four days before entry the patient experienced an abrupt onset of substernal "heaviness" that radiated to the left shoulder and back, accompanied by persistent dyspnea. One day later a . . .
Nuclear Cardiology
Authors: Harvey J. Berger, Barry L. Zaret
Journal: New England Journal of Medicine (1981)

Cardiovascular PerformanceIn 1971, the technique of gated cardiac blood-pool imaging was developed. In this approach, the electrocardiogram is introduced into the imaging process to control the temporal sequence of imaging of the entire equilibrium blood pool.97 , 98 This technique was initially proposed as a means of evaluating both regional wall motion and global left ventricular function. In the following year, first-pass radionuclide angiocardiography was described.99 In this approach, only the first transit of the radionuclide bolus through the central circulation is analyzed. Since their introduction, these two radionuclide techniques have progressed from the investigational stage to one of widespread clinical . . .
Abstract 18808: Higher Short Term Mortality in Sickle Cell Patients Presenting With ST Elevation Myocardial Infarction
Authors: Riaz Rahman, Raef Hajjali
Journal: Circulation (2015)

Introduction: Sickle cell disease (SCD) has been shown in multiple studies worldwide to be associated with considerable morbidity and mortality, including a higher risk for acute myocardial infarction (AMI). However, the effect of SCD on outcome in patients with myocardial infarction remains unclear. We sought to investigate the in-hospital mortality in patients with SCD presenting with acute ST elevation myocardial infarction (STEMI) compared to the general population. Hypothesis: Short term mortality in patients with SCD presenting with STEMI is higher when compared to the general population. Methods: The National Inpatient Sample (NIS), part of the Healthcare Cost and Utilization Project (HCUP), is the largest publicly available inpatient database designed to provide information on characteristics and outcomes of patients discharged from US hospitals. Using the NIS database, we identified 879,108 adult patients with a primary diagnosis of STEMI in the period between 1998 and 2012. Among this patient population, 52 patients also had a diagnosis of SCD. Results: Compared to the general population, patients with SCD were significantly younger (55 years vs. 66 years, p&lt;0.001), were more likely to be female (60% vs. 37%, p=0.001), and had a lower prevalence of hypertension (35% vs. 47%, p=0.06) and dyslipidemia (2% vs. 13%, p=0.02). They were less likely to undergo revascularization procedures compared to the general population (38% vs. 53%, p=0.04). The in-hospital mortality for patients with STEMI and SCD was 19.2% compared to 10.0% in patients without SCD (p=0.03). After adjusting for pertinent covariates using logistic regression analysis, SCD remained an independent predictor of higher in-hospital mortality (p=0.02, OR 2.4; 95% CI 1.1-5.1). Conclusions: Sickle cell patients have a higher in-hospital mortality compared to the general population when presenting with STEMI.
AB0208 Transcripts' Evaluation Involved in Fibrosis of Skin in Systemic Sclerosis: Environment Characterization and Association with Clinical Manifestations
Authors: R.S.G. Gonçalves, M.C. Pereira, A.T. Dantas, C.D.L. Marques, M.J.B.D.M. Rego, I.D.R. Pitta, A.L.B.P. Duarte, M.G.D.R. Pitta
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Although a number of cytokines and chemokines have been investigated as possible mediators of fibrosis in Systemic Sclerosis (SSc), specific correlation between cytokines and organ involvement have not been found yet, and a cytokine profile characteristic of SSc is far to be identified. <h3>Objectives</h3> Establish a profile of anti and profibrotic molecules involved in skin fibrosis of SSc patients. <h3>Methods</h3> The mRNA expression was detected by real-time quantitative polymerase chain reaction (RT-qPCR) in skin9s biopsies from 14 patients: 7 patients with cutaneous diffuse SSc (dSSc) and 7 patients with cutaneous limited SSc (lSSc), and 5 sex and age-matched controls. All patients with SSc were biopsied at a lesional forearm site, and met the American College of Rheumatology (ACR) criteria for the classification of SSc. The transcriptome of samples extracted from skin biopsies of SSc and healthy controls was observed using quantitative real-time-polymerase chain reaction (qRT-PCR) of eleven molecules: TGF-b, PDGF, CTGF, CCL3, IL-6, IL-13, IL-7, IFNg, IL-17, IL-22, and RORc <h3>Results</h3> The CCL3, IL-13, IFN-g and IL-7 were more expressed in the SSc9s skin (respectively, p=0.0002, p=0.0243, p=0.0335, p=0.0082) when compared with healthy controls. We found positive correlation in expression levels between CCL3 and IL-7 (p=0.0050 r =0.7187), besides a negative correlation between IL-7 and TGF-b (p=0,0136 r = -0,6527). Furthermore, we obtained relation with some clinical manifestation and the relative genes expression. <h3>Conclusions</h3> We demonstrated that the relative mRNA expression of IL-7, IFN-g, CCL3 e IL-13 were increased on the microenvironment of the SS9s skin when compared with the healthy controls. Our study suggests interesting correlation between IL-7 and CCL3, so we propose large studies with SSc to establish the real role of these two molecules. Furthermore, we also ratified the potential probability antifibrotic role of IL-7 as well IFN-g. <h3>Acknowledgements</h3> We thank Dr. Emerson Andrade Lima for performing the skin biopsies <h3>Disclosure of Interest</h3> None declared
Identification of genetic variants in pharmacokinetic genes associated with Ewing Sarcoma treatment outcome
Authors: S. Ruiz-Pinto, G. Pita, A. Patiño-García, P. García-Miguel, J. Alonso, A. Pérez-Martínez, A. Sastre, G. Gómez-Mariano, A. Lissat, K. Scotlandi, M. Serra, R. Ladenstein, E. Lapouble, G. Pierron, U. Kontny, P. Picci, H. Kovar, O. Delattre, A. González-Neira
Journal: Annals of Oncology (2016)
AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12).
Authors: Satoru Tanabe, Stefan K. Bohlander, Christine V. Vignon, Rafael Espinosa, Nanding Zhao, Pamela L. Strissel, Nancy J. Zeleznik-Le, Janet D. Rowley
Journal: Blood (1996)
SAT0123 Inheritance in Rheumatic Diseases (Rheumatoid Arthritis) and in Vitro Fertilization
Authors: M. Panchovska, F. Martinova, N. Nikolov, D. Stoychev
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In 1989 Gleicher and co-authors describe for the first time the so called reproductive autoimmune failure syndrome (RAFS) in women with infertility, endometriosis and high levels of autoantibodies. The complex interrelations between autoimmune diseases and reproductive processes are still investigated. In the context of assisted reproductive technologies there is a discussion about the induction of autoimmune disorders in relation with the hormonal therapy and the ovarian hyperstimulation, especially in the presence of genetic predisposition. <h3>Methods</h3> Case Report: A 30-year-old woman was operated in relation with Polycystic Ovary Syndrome (Stein–Leventhal syndrome). Subsequently due to impossibility for conception, 10 unsuccessful attempts of intrauterine insemination were conducted. In 2009 in accordance with the respective protocol an attempt for in vitro fertilization was made, again unsuccessful. In the progress of the assisted reproduction, hormonal preparations were applied. The patient developed arthralgias of the small joints of the hands and began self-treatment with non-steroid anti-inflammatory drugs. The mother of the patient has rheumatoid polyarthritis associated with Sjögren and Raynaud syndromes. Before the commencement of a new reproductive cycle, the young woman was immunologically analized. The presence of anti-nuclear antibodies (ANA-dsDNA) was discovered. The results of the other immunological tests were in the reference ranges. After the discontinuation of the hormonal drugs, the articular manifestations faded away and the immunological indicators returned to normal. The results of the immunogenotyping of the patient and her mother (using DNA-PCR-SSP) revealed carriage of HLA-A*01, B*08, Cw*07, DRB1*03, DQB1*02 haplotype in both. In 2013 after a new attempt for in vitro fertilization and hormonal therapy, the patient developed symmetrical arthritis of the small joints of the hands, positive anti-CCP antibodies and rentgenological erosive changes of the affected joints. (Registered after a 10 month self-treatment with non-steroid anti-inflammatory and analgesic drugs.) <h3>Conclusions</h3> Discussion: The presented case demonstrates a strong predisposition towards autoimmune diseases, associated with the carriage of the pointed out haplotype: HLA-A*01, B*08, Cw*07, DRB1*03, DQB1*02. In the case of the mother there are clinical manifestations of autoimmune rheumatic diseases – rheumatoid arthritis, Sjögren and Raynaud syndromes. Meanwhile in the young woman the autoimmune disease is initially disguised by the presence of ANA and infertility. During a subsequent attempt for in vitro fertilization and hormonal therapy, the patient develops seropositive rheumatoid arthritis. <h3>Disclosure of Interest</h3> None declared
Physicians' self-reports of reactions to malpractice litigation
Authors: S C Charles, J R Wilbert, E C Kennedy
Journal: American Journal of Psychiatry (1984)

The authors devised a survey as a first step in assessing physicians' perceptions of the impact of medical malpractice litigation on their professional practice and personal lives. Subjects were a sample of physicians in Cook County, Ill., who had been sued during 1977-1981. Many respondents reported changes in how they practiced their profession. Two clusters of self-reported symptoms in reaction to the litigation also emerged. Further studies, including clinical interviews, are needed to clarify the impact of medical malpractice suits on the sociological reality of medical practice.
Case 24-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely
Journal: New England Journal of Medicine (1982)

Presentation of Case A 51-year-old woman was admitted to the hospital because of asthma and hemoptysis. There was a history of bronchial asthma that began in childhood and was severe for the past 25 years. During the 10 years before entry she was admitted to another hospital about once a year for a stay of one to two weeks because of wheezing. Her treatment included adrenocorticosteroids. Wheezing was precipitated by exposure to molds, feathers, and animals and followed respiratory-tract infections. Two years before admission she was treated at another hospital for pneumonia of the left lower lobe, and a diagnosis . . .
FRI0506 High Prevalence of Extracutaneous Manifestations and Comorbidities in 108 Patients with Juvenile Localized Scleroderma
Authors: A.K. Kienast, I. Foeldvari
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile localized scleroderma (jLS) is an orphan disease. Only one large survey looked at the prevalence of extracutaneous involvement (EI), but without a standardised assessment protocol. <h3>Objectives</h3> Aim of our study was to assess retrospectively EI and comorbidities (CM) of patients with jLS. <h3>Methods</h3> We performed a retrospective chart review of consecutive patients with jLS seen in our centre for paediatric rheumatology from May 1999 until October 2014. We collected information regarding demographics, EI and CM. <h3>Results</h3> 108 patients were identified. 85 of them had at least one follow up appointment. Mean time of follow- up of the patients was 36.8 months. Mean disease duration to first visit was 50.4 months (n=101). 70 of the 108 patients (64.8%) patients were female. The subset distribution of jLS (n=108) was 28.7% linear scleroderma of the trunk/limbs and 21.3% linear scleroderma of the head (“en coup the sabre”); 24.1% mixed morphea, 9.3% circumscribed superficial morphea, 8.3% generalized, 7.4% circumscribed deep morphea and 0.9% pansclerotic morphea. Mean age at first visit was 12.6 years and 14 patients were older than 18 years old at the time of their first visit. 46 (43%) of the patients showed extracutaneous manifestations. 47 of the 85 were clinically screened for temporomandibular joint arthritis (TMJ) and 9 (19.1%) showed signs of TMJ- arthritis, of these 9 patients had arthritis on clinical exam, 8 on MRI. 3 patients of 72 (4.2%) who were followed and examined by an ophthalmologist developed anterior uveitis. As clinical consequences of the extracutaneous manifestations 5.5% developed lateral trusion at mouth opening, 4.6% decreased mouth opening, 22.2% contractures and 5.5% restricted joint range in non-TMJ. 13% developed length discrepancy of the effected limb and 5.5% leg dystrophy. No patient developed visual impairment. 49 of the 108 patients showed 43 different comorbidities: 7.4% had juvenile idiopathic arthritis, 0.9% rheumatoid arthritis, 6.5% were diagnosed with allergies and 6.5% of atopic eczema, 4% scoliosis, 3.7% migraine and 1.8% hashimoto-thyreoiditis. <h3>Conclusions</h3> This retrospective analysis shows a high incidence of patients with EI like TMJ- arthritis, arthritis and uveitis. We would recommend regular clinical investigations for assessment of arthritis, especially TMJ- arthritis and uveitis at least 6 monthly, as suggested from the PReS Scleroderma working group. The extracutaneous manifestations were most common in linear scleroderma of the trunk/limbs subtype. <h3>Disclosure of Interest</h3> None declared
Nucleolar Volume Changes in the Mouse Pancreas after Repeated Pilocarpine Injections&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Hisako O. Yokoyama, Robert E. Stowell
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Nucleolar Volume Changes in the Mouse Pancreas after Repeated Pilocarpine Injections Get access Hisako O. Yokoyama, Hisako O. Yokoyama Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert E. Stowell Robert E. Stowell Department of Oncology, University of Kansas Medical Center, Kansas City, Kansas. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 5, April 1951, Pages 939–945, https://doi.org/10.1093/jnci/11.5.939 Published: 01 April 1951 Article history Received: 14 December 1950 Published: 01 April 1951
CARDIAC ALLOGRAFT VASCULOPATHY AND SURVIVAL AFTER HEART TRANSPLANTATION FOR CHAGAS &amp;lsquo;HEART DISEASE
Authors: Mirta Diez, Liliana Favaloro, Alejandro Bertolotti, Carlos Vigliano, Margarita Peradejordi, Alejandro Schijman, Roberto Favaloro
Journal: Journal of the American College of Cardiology (2012)