tbuckley/cabot-search huggingface dataset:
Soft tissue injuries are still a challenge in musculoskeletal sports and exercise medicine
Authors: Nikos Malliaropoulos, Mourad Ghrairi, Yacine Zerguini, Nat Padhiar
Journal: British Journal of Sports Medicine (2016)

Soft tissue injuries in sports are a challenge both for sports and exercise medicine practitioners, athletes, coaches and the team. In this issue we present the latest research on hamstring, ankle, groin and Achilles tendon injuries.

Lateral ankle sprain has a high prevalence both in the athletic and the general population. Even though it is a common injury it can be associated with long term complications such as chronic ankle instability. The Executive Committee of the International Ankle Consortium presents their position recommendations for information, implementation and continued research in order to improve prevention and early management of lateral ankle sprain and reduce the prevalence of long-term sequelae ( see pages 1493 and 1496 ).

Hamstring injuries are still quite a challenge. This edition includes a a PEDro systematic review update on the conservative management for hamstring injuries. This …
Incidence and Outcomes of a Rare Translocation t(3,5) in Patients (pts) with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)
Authors: Mona Lisa Alattar, Hagop M. Kantarjian, Jorge E. Cortes, Tapan M. Kadia, Gautam Borthakur, Maro Ohanian, Farhad Ravandi, Guillermo Garcia-Manero, Alfonso Quintas-Cardamas, Elias Jabbour, Naval Daver, Sherry A. Pierce, Mark Brandt, Stefan Faderl, Naveen Pemmaraju
Journal: Blood (2012)
Better evidence for smarter policy making
Authors: David J Hunter, Shelina Visram
Journal: BMJ (2016)

European countries endorse WHO’s action plan 

As countries struggle to transform their health systems to cope with rising demand, ageing populations, and largely avoidable lifestyle related illnesses within limited budgets, policy makers are desperate for the right kind of evidence. It is not the “what” question that preoccupies them, since the main components of health system transformation are well known and accepted, but how to implement them.1

It is therefore timely that WHO Europe is seeking to strengthen the use of evidence and research for policy making. Its action plan was endorsed by all 53 member states at the recent regional committee meeting in Copenhagen.2 The goal is to consolidate, strengthen, and promote the generation and use of multidisciplinary and intersectoral sources of evidence for making health policy in line with the health related sustainable development goals and the Health 2020 policy framework.3 One of the four agreed areas for action is knowledge translation and …
IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus
Authors: S Drennan, A D'Avola, Y Gao, C Weigel, E Chrysostomou, A J Steele, T Zenz, C Plass, P W Johnson, A P Williams, G Packham, F K Stevenson, C C Oakes, F Forconi
Journal: Leukemia (2016)
Identification and Monitoring of Pathogenic T Cell Clones Using Deep TCR Sequencing in T-Large Granular Lymphocyte Leukemia and Aplastic Anemia
Authors: Michael J. Clemente, Bartlomiej Przychodzen, Hideki Makishima, Manuel G. Afable, Marcin W Wlodarski, Alan E. Lichtin, Jaroslaw P. Maciejewski
Journal: Blood (2012)
Bortezomib (Velcade) When Given Pretransplant and Once Weekly as Consolidation Therapy Following High Dose Chemotherapy (HDCT) Leads to High Rates of Reactivation of Varicella Zoster Virus (VZV).
Authors: Shachar Peles, Nicholas M. Fisher, Steven M. Devine, Michael H. Tomasson, John F. DiPersio, Ravi Vij
Journal: Blood (2005)
Prevalence, Profile, and Prognosis of Severe Obesity in Contemporary Hospitalized Heart Failure Trial Populations
Authors: Emer Joyce, Anuradha Lala, Susanna R. Stevens, Lauren B. Cooper, Omar F. AbouEzzeddine, John D. Groarke, Justin L. Grodin, Eugene Braunwald, Kevin J. Anstrom, Margaret M. Redfield, Lynne W. Stevenson
Journal: JACC Heart Failure (2016)
Activation of the mTOR Signaling Pathway in Multiple Myeloma Patients and Its Prognostic Significance.
Authors: Tommasina Guglielmelli, Susanna Cappia, Emilia Giugliano, Roberta Merlini, Stefano Mussino, Elena Bacillo, Enrico Bracco, Maurizio Papotti, Giuseppe Saglio
Journal: Blood (2007)
Significant Correlation between Survival Endpoints and Exposure to Ofatumumab (HuMax-CD20) in Chronic Lymphocytic Leukemia.
Authors: Bertrand Coiffier, H. Tilly, L.M. Pedersen, T. Plesner, H. Frederiksen, M.H.J. van Oers, J. Wooldridge, J.S. Kloczko, J. Holowiecki, A. Hellmann, J. Walewski, M. Flensburg, J. Petersen, T. Robak
Journal: Blood (2006)
Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism
Authors: Grant Kauwe, Kazuya Tsurudome, Jay Penney, Megumi Mori, Lindsay Gray, Mario R. Calderon, Fatima Elazouzzi, Nicole Chicoine, Nahum Sonenberg, A. Pejmun Haghighi
Journal: Neuron (2016)
Influence of Genetic Variability of GSTM1 and GSTT1 Null Alleles Between Donor and Recipient in the Development of Acute Graft Versus Host Disease.
Authors: Alejandro Contento-Gonzalo, Magdalena Alcala-Peña, Manuel Barrios, Macarena Ortiz-Pareja, Antonio Jiménez-Velasco, José Román-Gómez, Antonio P. Torres Gomez, Ana Isabel Heiniger
Journal: Blood (2009)
ASBMT Risk Group and CD 34+ Dose Predicted for the Development of aGVHD in Allogeneic MRD Transplants When the Donors Who Received a Combined Mobilization and In Vivo TCD Regimen Using rhg-CFS and Dexamethasone.
Authors: Khaleel K. Ashraf, Arabella B. Tilden, Yufeng Li, Sameer Gupta, Lawrence S. Lamb, Donna E. Salzman, Richard Lopez, William P. Vaughan
Journal: Blood (2007)
Tyrosine 641 of the EZH2 Oncogene Is Frequently Mutated in Follicular and Diffuse Large B-Cell Lymphomas of Germinal Center Origin.
Authors: Ryan Morin, Nathalie Johnson, Tesa Severson, Andrew J. Mungall, Jianghong An, Jessica Paul, Merrill Boyle, Bruce Woolcock, Florian Kuchenbauer, Damian Yap, R. Keith Humphries, Obi Griffith, Sohrab P Shah, Richard Corbett, Angela Tam, Richard Varhol, Duane Smailus, Michelle Moksa, Yongjun Zhao, Allen Delaney, Hong Qian, Inanc Birol, Henry Zhu, Michelle Kimbara, Pavel Shashkin, Jean Charlot, Marianna Tcherpakov, Samuel Aparicio, Jacqueline E. Schein, Richard Moore, Robert A. Holt, Doug Horsman, Joseph M. Connors, Steven Jones, Martin Hirst, Randy D. Gascoyne, Marco A. Marra
Journal: Blood (2009)
Lenalidomide (CC5013, Revlimid®) Promotes T Helper-1 Function Bias and Increases Responsiveness to Autologous Bone Marrow Antigens in Myelodysplastic Syndrome (MDS).
Authors: Edna Ku, JianXiang Zou, Fanqi Bai, Jeffrey S. Painter, Alan F. List, P.K. Epling-Burnette
Journal: Blood (2006)
Molecularly Defined Clonal Evolution in Patients with Chronic Myeloid Leukemia Independent of the BCR-ABL Status
Authors: Thomas Ernst, Mathias Schmidt, Jenny Rinke, Vivien Schäfer, Anja Waldau, Ellen Obstfelder, Nils Winkelmann, Janine Ziermann, Susanne Schnittger, Torsten Haferlach, Claudia Haferlach, Andreas Hochhaus
Journal: Blood (2014)
Prognostic Value of Immunophenotype in Patients with Non-Promyelocytic Acute Myeloid Leukemia Treated with Intensive Chemotherapy. A Single Centre Study.
Authors: Pau Montesinos, Amparo Sempere, Federico Gomis, Jose Cervera, Mariluz Perez-Sirvent, Leonor Senent, Ninotchka Mendoza, Jaime Sanz, Noemi Puig, Federico Moscardo, Guillermo Martin, Ignacio Lorenzo, Jesus Martinez, Javier de la Rubia, Javier Palau, Guillermo Sanz, Miguel Sanz
Journal: Blood (2007)
Donor NK Cell Engraftment and Overall and Progression-Free Survivals after Allogeneic Hematopoietic Cell Transplantation (HCT) with Nonmyeloablative Conditioning.
Authors: Frederic Baron, T. Gooley, M.T. Little, E. Petersdorf, M. Malkki, D. Maloney, M. Maris, P. Stroup, S. Shin, J. Baker, T. Chauncey, K. Blume, B. Sandmaier, R. Storb
Journal: Blood (2005)
Liposomal Amphotericin B (L-AMB) Is Superior to Amphotericin B Deoxycholate (AmB-d) in Preventing Breakthrough Fungal Infections in Patients with Prolonged Neutropenia and Fever: Results of a Sub-Group Analysis of an Empirical Antifungal Therapy Trial.
Authors: Catherine Cordonnier, Thomas J. Walsh, Mark Bresnik
Journal: Blood (2004)
Effects of Direct Factor Xa Inhibitor, YM150, on Clot Formation and Clot Lysis In Vitro Compared with Other Anticoagulants.
Authors: Seiji Kaku, Ken-ichi Suzuki, Toshiyuki Funatsu, Minori Saitoh, Hiroyuki Koshio, Tsukasa Ishihara, Fukushi Hirayama, Tomihisa Kawasaki
Journal: Blood (2007)
A Monoclonal Antibody to Lactadherin Inhibits Sickle Red Blood Cell Adhesion to Vascular Endothelial Cells in a Plasma Milieu.
Authors: Swapan K. Dasgupta, Prasenjit Guchhait, Anhquyen Le, Sarvari Yellapragada, Jose Lopez, Perumal Thiagarajan
Journal: Blood (2006)
Profiles of Antibodies Specific to Platelet Glycoproteins in ITP Differ in Remission, Relapse and Stable Phases; and Anti-GpIIb/IIIa, -GpIb/IX Were Associated with Bleeding Manifestations.
Authors: Carlos J. Bidot, Wenche Jy, Lawrence L. Horstman, Eugene Ahn, Vincenzo Fontana, Yisel Valdes, Rayden Llano, Loreta Bidot, Yeon S. Ahn
Journal: Blood (2005)
Low Representation of ETV6-RUNX1 Fusion Oncogene in Pediatric Acute Lymphoblastic Leukemia Patients from Saudi Arabia and Strong Association with Clinical Response to Day-14 of Remission Induction Therapy
Authors: Khalid Aljamaan, Talal Khalid Aljumah, Saleh Aloraibi, Muhammad Absar, Giuseppe Saglio, Zafar Iqbal
Journal: Blood (2015)
Development of a Novel in Vivo Model for Human Myeloma Via Humanization of the Bone Marrow Niche
Authors: Till Strowig, Anja Hafemann, Stephanie Hopf, Kartik Sehgal, Srinivas Koduru, Mehmet H. Kocoglu, Rituparna Das, Madhav V. Dhodapkar, Richard A. Flavell
Journal: Blood (2012)
Zoledronic Acid (ZOL) Markedly Improves Bone Mineral Density (BMD) for Patients (Pts) with Monoclonal Gammopathy of Undetermined Significance (MGUS) and Bone Loss.
Authors: James R. Berenson, Ori Yellin, Ralph V. Boccia, Marshall S. Flam, Siu-Fun Wong, Olcay Batuman, Mehdi M. Moezi, Donald Woytowitz, Herb Duvivier, Youram Nassir, Regina A. Swift
Journal: Blood (2007)
Hematopoietic Allotransplant Studies in Complement Deficient Mice Reveal Beneficial Role of Innate Immunity in Ameliorating Consequences of GVHD.
Authors: Oktawiusz Wiecha, Witold Miezynski, Leszek Wojakiewicz, Anna Zebzda, Anna Wendrychowicz, Jolanta Gozdzik, Mariusz Z. Ratajczak, Marcin Majka
Journal: Blood (2006)
The C677T Polymorphism in the Methylenetetrahydrofolate Reductase (MTHFR)Gene Is an Important Determinant of Bone Mineral Density in Pediatric Acute Lymphoblastic Leukemia Patients.
Authors: Robert D. van Beek, Sabine M.P.F. de Muinck Keizer-Schrama, Robert de Jonge, Rob Pieters, Marry M. van den Heuvel-Eibrink
Journal: Blood (2004)
Genetic and Functional Investigation of Germline JAK2 Alleles That Predispose to Myeloproliferative Neoplasms
Authors: Alison M Schram, Xing Xu, Outi Kilpivaara, Semanti Mukherjee, Aaron D Viny, Olga Guryanova, Robert J Klein, Ross L Levine
Journal: Blood (2011)
ETNK1 Is an Early Event and SETBP1 a Late Event in Atypical Chronic Myeloid Leukemia
Authors: Antonio Niro, Rocco Piazza, Gabriele Merati, Alessandra Pirola, Carla Donadoni, Diletta Fontana, Sara Redaelli, Caterina Mezzatesta, Rossella Renso, Francesca Farina, Delphine Rea, Carlo Gambacorti-Passerini
Journal: Blood (2015)
T-Cell Large Granular Lymphocyte (T-LGL) Expansion Post Adult Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) – ‘A Prognostic Indicator for Improved Overall Survival’.
Authors: Mayur S Ramesh, Zaid Al-Kadhimi, Stephanie Mellon-Reppens, Jason Valent, Lawrence G Lum, Lois Ayash, Muneer H Abidi, Voravit Ratanatharathorn, Joseph Uberti
Journal: Blood (2009)
Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β phosphorylation in a tau transgenic Drosophila model of Alzheimer’s disease
Authors: Bei Zhang, Qiongqiong Li, Xingkun Chu, Suya Sun, Shengdi Chen
Journal: Translational Neurodegeneration (2016)

Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment against AD. Salidroside (Sal) is the main effective component of Rhodiola rosea L., which has several pharmacological activities. The objective of this study was to investigate the efficacy of Sal in the treatment of AD transgenic Drosophila and the associated mechanisms.We used tau transgenic Drosophila line (TAU) in which tau protein is expressed in the central nervous system and eyes by the Gal4/UAS system. After feeding flies with Sal, the lifespan and locomotor activity were recorded. We further examined the appearance of vacuoles in the mushroom body using immunohistochemistry, and detected the levels of total glycogen synthase kinase 3β (t-GSK-3β), phosphorylated GSK-3β (p-GSK-3β), t-tau and p-tau in the brain by western blot analysis.Our results showed that the longevity was improved in salidroside-fed Drosophila groups as well as the locomotor activity. We also observed less vacuoles in the mushroom body, upregulated level of p-GSK-3β and downregulated p-tau following Sal treatment.Our data presented the evidence that Sal was capable of reducing the neurodegeneration in tau transgenic Drosophila and inhibiting neuronal loss. The neuroprotective effects of Sal were associated with its up-regulation of the p-GSK-3β and down-regulation of the p-tau.
Use of Magnetic Resonance Imaging to Visualize Leptomeningeal Inflammation in Patients With Multiple Sclerosis
Authors: Jonathan Zurawski, Hans Lassmann, Rohit Bakshi
Journal: JAMA Neurology (2016)

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system traditionally characterized by an initial relapsing-remitting clinical course and focal inflammatory lesions that have a predilection for the periventricular white matter. Recently, however, histopathologic and imaging studies have illustrated a more complex pathologic substrate involving cortical demyelination, gray matter atrophy, and meningeal inflammation. Neuroimaging advances have facilitated improved detection of cortical pathology, but our understanding of the pathogenesis of cortical disease remains incomplete. The purpose of this review is to evaluate the current status and future prospects regarding the emerging role of magnetic resonance imaging to visualize leptomeningeal enhancement in patients with MS and place these findings in the proper pathobiologic and clinical context.Cortical atrophy and demyelination along the subpial surface appear early in the disease course in patients with MS but accelerate in progressive stages. Histopathologic studies of patients have shown the presence of inflammatory infiltrates, in some cases with features of B cell-rich tertiary lymph follicles, along the cortical meningeal surface. Recent magnetic resonance imaging data demonstrate the ability to detect such inflammation using high-resolution gadolinium-enhanced contrast scans by the presence of leptomeningeal enhancement. Clinical and magnetic resonance imaging correlation studies indicate that leptomeningeal enhancement is most common in patients with progressive forms of MS and shows a relationship to subpial cortical lesions and cortical atrophy.A growing body of evidence suggests that gray matter demyelination, cortical atrophy, and leptomeningeal inflammation may be important components of progressive MS pathology and provide a new therapeutic target. Leptomeningeal enhancement may prove a useful surrogate marker for such pathology, perhaps improving our understanding of the natural history of progressive MS, although its ultimate effect on therapeutic development and clinical care requires further study.
Signaling Mechanisms of Anti-Proliferation by Sphingosine 1-Phoshate(S1P) on Acute Promyelocytic Leukemia(APL) Cell Lines.
Authors: Yeung-Chul Mun, Eui-Soo Hwang, Kyoung-Eun Lee, Jung Mi Kwon, Seung-Hyun Nam, Eun Sun Yoo, Yun-Kyung Bae, Seung-Eun Lee, Jee-Young Ahn, Myung Soo Hyun, Ki Young Kwon, Soon Nam Lee, Chu-Myong Seong
Journal: Blood (2004)
Over 30% of Smoldering Myeloma Patients Have Tumor Cell Bone Marrow Infiltration Patterns Similar to Multiple Myeloma: A Large (n=544) Clinical Study Using Whole-Body MRI.
Authors: Jens Hillengass, Kerstin Kilk, Karin Listl, Thomas Hielscher, Kai Neben, Dirk Hose, Marc-André Weber, Anthony D. Ho, Hartmut Goldschmidt, Ola Landgren
Journal: Blood (2012)
Improved Survival in Patients with Peripheral T Cell Lymphoma, Unspecified Following High-Dose Therapy and Stem Cell Transplantation: A Retrospective Review of a Single Institution’s Experience.
Authors: Ryan A. Wilcox, Ahmet Dogan, Kay Ristow, Joseph P. Colgan, Thomas M. Habermann, David J. Inwards, Patrick B. Johnston, Svetomir N. Markovic, Ivana N. M. Micallef, Luis F. Porrata, Thomas E. Witzig, Stephen M. Ansell
Journal: Blood (2006)
Plantar Shear Stress in Individuals With a History of Diabetic Foot Ulcer: An Emerging Predictive Marker for Foot Ulceration
Authors: Metin Yavuz, Ali Ersen, Jessica Hartos, Brandy Schwarz, Alan G. Garrett, Lawrence A. Lavery, Dane K. Wukich, Linda S. Adams
Journal: Diabetes Care (2016)

Plantar shear stress has been held accountable as a causative factor in diabetic foot ulcers (DFU) (1,2). Delbridge et al. (2) recognized shear stress as a major causative factor by stating that it is shear rather than vertical load that is responsible for tissue breakdown that occurs deep to the skin. Historically, research in this area has been hampered by an underestimation of the importance of shear stress and the lack of technology to measure it. Emerging evidence within the past decade has demonstrated the clinical significance of shear to foot ulceration (3–5). We previously revealed that individuals with diabetic neuropathy (DN) experience higher plantar shear compared with control subjects (5). However, to our knowledge, no study has compared peak shear in individuals with a history of DFU to those patients with DN but no history of DFU.

We quantified peak plantar shear (PS) in 9 subjects with (DFU) and 16 DN subjects without (DN) previous ulcers …
Safety and Efficacy of Ibrutinib in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Who Have Undergone Prior Allogeneic Stem Cell Transplant
Authors: Steven Coutre, Susan O'Brien, John C. Byrd, Peter Hillmen, Jennifer R. Brown, Martin JS Dyer, Anthony R. Mato, David B. Miklos, Michael Keating, Cathy Zhou, Maria Fardis, Lori Styles, Samantha Jaglowski
Journal: Blood (2014)
Standardized Long-Term Follow-up after Allogeneic Stem Cell Transplantation: A Cross-Sectional 1-Year Evaluation in 260 Adults
Authors: Maria Teresa Lupo-Stanghellini, Andrea Assanelli, Alessia Orsini, Raffaella Greco, Fabio Giglio, Sara Mastaglio, Mara Morelli, Francesca Pavesi, Elisa Sala, Margherita Brambilla, Simona Piemontese, Elisabetta Xue, Luca Vago, Carlo Messina, Serena Camilla Dalto, Francesca Lorentino, Lucia Malabarba, Ambra Malerba, Magda Marcatti, Elena Guggiari, Sarah Marktel, Matteo G Carrabba, Francesca Lunghi, Massimo Bernardi, Chiara Bonini, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri
Journal: Blood (2015)
A Phase II Trial of the Oral mTOR Inhibitor Everolimus (RAD001) in Relapsed Aggressive Non-Hodgkin Lymphoma (NHL).
Authors: Craig B. Reeder, Michel K. Gornet, Thomas M. Habermann, Stephen M. Ansell, Ivana N. Micallef, Luis F. Porrata, Patrick B. Johnston, Matthew J. Maurer, Betsy LaPlant, Brian Kabat, David J. Inwards, Joseph P. Colgan, Timothy Call, Svetomir Markovic, Clive S. Zent, Steven R. Zeldenrust, Han W. Tun, Thomas E. Witzig
Journal: Blood (2007)
Efficacy, PK and Safety Results of a Phase I/II Clinical Trial of Recombinant Fusion Protein Linking Coagulation Factor IX with Albumin (rIX-FP) in Previously Treated Patients with Haemophilia B (PROLONG - 9FP)
Authors: Uriel Martinowitz, Aaron Lubetsky, Elena Santagostino, Gantcho Jotov, Jacob Luboshitz, Shadan Lalezari, Tami Barazani-Brutman, Christine Voigt, Tina Moises, Iris C. Jacobs, Toshko Lissitchkov
Journal: Blood (2012)
Oral Realgar-Indigo Naturalis Formula Achieved Comparably High Rate of Remission and Survival to Intravenous Arsenic Trioxide As a Front-Line Treatment in Newly Diagnosed Acute Promyelocytic Leukemia: A Multi-Center Randomized Trial APL07
Authors: Zhu-Hong Zhu, De-Pei Wu, Jie Jin, Jian-Yong Li, Jun Ma, Jiangxiang Wang, Hao Jiang, Sai-Juan Chen, Xiao-Jun Huang
Journal: Blood (2012)
GENO-37MOLECULAR PROFILING OF LONG-TERM SURVIVORS OF GLIOBLASTOMA
Authors: Ryan Youland, Dioval Remonde, Alissa Caron, Ann Mladek, Paul Decker, Hughes Sicotte, Daniel Lachance, Benjamin Kipp, Jeanette Eckel-Passow, Jason Huse, Caterina Giannini, Robert Jenkins, Jann Sarkaria
Journal: Neuro-Oncology (2015)

Few patients with glioblastoma survive beyond 5 years. In this project, the molecular features associated with these exceptional long term survivors (LTS) were evaluated. Patients diagnosed with glioblastoma within the past 30 years surviving >= 5 years were identified from the Mayo tumor registry. Of 1176 patients with glioblastoma in the registry, 40 were LTS (median age 50.4 years; median survival 7.8 years). Pathology was reviewed and diagnosis confirmed by a certified neuropathologist (CG). Histology was fibrillary in 30 (75%) patients. Most (23, 58%) tumors were located in the frontal lobes. Gross total resection was achieved in 26 (65%). Adjuvant radiotherapy was delivered in 35 ( >= 60 Gy in 31). Temozolomide was given in 20 (50%) and BCNU in 12 (30%). In the 22 patients with tissue available for analysis (median age 49.2 years; median survival 7.0 years), TCGA molecular subtype breakdown from RNA extracts analyzed by Nanostring was: proneural 11, neural 0, classical 6, mesenchymal 2, and unknown 3 (insufficient RNA). Next-generation sequencing revealed the following mutations: 12 TERT, 12 ATRX, 12 TP53, 10 IDH, 8 PIK3CA/PIK3R1, 8 PTEN, 4 RB1, and 3 EGFR. 1p19q codeletion (determined via OncoScan assay), TERT, and IDH mutations were used to stratify patients into risk categories: 9 TERT-mutation only, 8 IDH-mutation only, 2 triple positive, and 3 triple negative. The frequency of IDH mutation in LTS (8/22) was significantly higher than observed in a contemporaneous cohort of short-surviving glioblastoma (32/470, p < 0.0001). All IDH mutations were in TCGA proneural patients. Long-term glioblastoma survival is enriched for patients with IDH-mutation only gliomas, although approximately half of tumors have molecular features associated with a more typical aggressive clinical course. Future studies are focused on understanding the mechanisms associated with prolonged survival in the TERT-mutation only tumors.
P0330 : Cost-effectiveness analysis of hepatocellular carcinoma surveillance in patients with hepatitis C related cirrhosis after sustained virological response
Authors: H. Farhang Zangneh, W.W. Wong, B. Sander, C.M. Bell, K. Mumtaz, M. Kowgier, A.J. Van Der Meer, S.P. Cleary, K. Chan, J.J. Feld
Journal: Journal of Hepatology (2015)