tbuckley/cabot-search huggingface dataset:
Diagnostic rate of comorbid personality disorder in elderly psychiatric inpatients
Authors: M E Kunik, B H Mulsant, A H Rifai, R A Sweet, R Pasternak, G S Zubenko
Journal: American Journal of Psychiatry (1994)

Among 547 elderly inpatients grouped by DSM-III-R axis I diagnoses, the diagnostic rate of comorbid personality disorder varied four-fold, from 6% in patients with an organic mental disorder to 24% in those with major depression. The previously reported low prevalence of comorbid personality disorder in geriatric patients may be due to its lower rate of diagnosis among patients with organic mental disorders.
The National Epirubicin Adjuvant Trial (NEAT) and Scottish Cancer Trials Breast Group (SCTBG) br9601 randomized phase III adjuvant early breast cancer trials: The updated definitive joint analysis
Authors: H. Earl, L. Hiller, J. A. Dunn, S. Bathers, R. J. Grieve, D. Spooner, R. K. Agrawal, L. Foster, C. Twelves, C. J. Poole
Journal: Journal of Clinical Oncology (2007)

534 Background: NEAT and the SCTBG BR9601 trial address the role of Epirubicin (E) as an adjunct to CMF in adjuvant chemotherapy for women with early breast cancer (EBC). Methods: NEAT compared E (100mg/m 2 x4cycles) followed by classical (c)CMF (x4cycles) with cCMF (x6cycles); BR9601 compared E (100mg/m 2 × 4cycles) followed by iv dose modified CMF q3w (750:50:600 ×4cycles) with iv CMF (x8cycles). Eligibility was completely excised EBC, requiring adjuvant chemotherapy, and start of treatment &lt;10 wks from surgery. Primary outcome measures were relapse-free-survival (RFS) and overall survival (OS). A joint efficacy analysis of NEAT (n=2,021) and BR9601 (n=370) triggered by planned 5-year median follow-up (FU) and estimated 800 RFS events and 600 deaths has 85% power to detect 5% two-sided differences. Results: In 2,391 eligible patients, characteristics were balanced across treatments: 72% node +ve; 59% &lt;50 years old; 47% pre-menopausal; 58% tumours grade 3; 55% &gt;2cms; 32% ER-ve, 50% ER+ve (18% NA). At a median FU of 6.2 yrs, 710 relapses or deaths without relapse and 570 deaths are observed. Despite lower than anticipated event rates in the control arm, these updated results confirm a highly significant benefit in favour of ECMF for both RFS (HR 0.75 (95%CI 0.64–0.87) p=0.0002) and OS (HR 0.74 (0.62–0.87) p=0.0004), independent of trial and prognostic factors. In 1458 NEAT patients (in whom data are available), 68% were to receive tamoxifen; chemotherapy scheduling data is available for 843, of whom 46% were declared concurrent and 54% sequential. In a non-pre-planned retrospective analysis, sequential tamoxifen shows a trend for advantage on RFS (HR 0.78 (0.59–1.02) p=0.06). We have amenorrhoea data on 598 NEAT and BR9601 pre-menopausal women, of whom 72% became amenorrhoeic by the end of chemotherapy. In this instance, developing amenorrhoea showed no advantage for RFS (HR 0.90 (0.65–1.24) or OS (HR 0.99 (0.68–1.44)). Conclusions: This updated definitive analysis adds to the Overview in respect of an anthracycline advantage and confirms ECMF as an established and effective standard adjuvant therapy for EBC. [Table: see text]
Prognostic Impact of Immune Response in Resectable Colorectal Liver Metastases Treated with and Without Perioperative Folfox Chemotherapy
Authors: E. Tanis, C. Julie, J. Emile, B. Nordlinger, M. Mauer, D. Aust, A.D. Roth, M.P. Lutz, T. Ruers
Journal: Annals of Oncology (2014)
REACTIVITY OF ANTINUCLEAR ANTIBODIES WITH HISTONES AND OTHER ANTIGENS IN JUVENILE RHEUMATOID ARTHRITIS
Authors: Peter Malleson, Ross E. Petty, Marinda Fung, E. Peter M. Candido
Journal: Arthritis & Rheumatology (1989)

Antinuclear antibodies are found in serum samples from most children with juvenile rheumatoid arthritis (JRA), but the antigenic specificities of these antibodies are not known. Using an immunoblot technique, we found that JRA patients' sera react with a variety of proteins in the nuclei of HEp-2 cells. Antibody to histone H1 was found in 42% of the JRA serum samples. An IgG antibody to a 45-kd protein was found in serum samples from some patients without uveitis, but it was not found in any sample from patients with uveitis. The immunoblot reactivity patterns do not appear to be useful in distinguishing between disease onset types or disease course types in patients with JRA.
Size of the Androgen Receptor CAG Repeat and Prostate Cancer: Does It Matter?
Authors: Gerhard Coetzee, Ryan Irvine
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.17.3572 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12202654 Size of the Androgen Receptor CAG Repeat and Prostate Cancer: Does It Matter? Gerhard CoetzeexGerhard CoetzeeSearch for articles by this author , Ryan IrvinexRyan IrvineSearch for articles by this author Show More University of Southern California/Norris Cancer Center, Keck School of Medicine, Los Angeles, CA https://doi.org/10.1200/JCO.2002.20.17.3572 Full Text PDF Figures and Tables "Size of the Androgen Receptor CAG Repeat and Prostate Cancer: Does It Matter?." Journal of Clinical Oncology, 20(17), pp. 3572–3573© 2002 by American Society of Clinical Oncology
FDG-PET/CT Manifestation of Tumor Seeding Along Percutaneous Biliary Drainage Catheter Tract
Authors: Darshan Patel, Yang Lu
Journal: Clinical Nuclear Medicine (2015)

A 55-year-old man with liver metastases from colon cancer developed obstructive jaundice secondary to bile duct compression from tumor burden, which required percutaneous biliary drainage until subsequent internal biliary stent could be placed. Follow-up FDG-PET/CT performed 2 months after removal of percutaneous biliary drainage catheter revealed FDG avid metastases along the catheter tract, extending from anterior abdominal wall to the peripheral liver at the insertion site of previous biliary catheter.
A pilot study of molecularly tailored therapy for patients with metastatic pancreatic cancer (MPC).
Authors: Michael J. Pishvaian, Hongkun Wang, Aiwu Ruth He, Lisa Ley, Karen Dorsch-Vogel, Marion L. Hartley, Erin Carney, Louis M. Weiner, Brandon George Smaglo, Jonathan Robert Brody, John Marshall
Journal: Journal of Clinical Oncology (2015)

329 Background: We have entered an era where multiple chemotherapeutic (chemo) agents can be utilized in the treatment (Tx) of patients (pts) with MPC. However, there are no methods for selecting the optimal regimen for any individual pt, and pure empiricism has not proven to be an optimal strategy. Molecular profiling is now widely used, albeit without evidence-based studies linking molecular profiles to Tx choices. Methods: We initiated a pilot study to assess the feasibility of following a simple algorithm, basing Tx on 3 published predictive markers of response to chemo: RRM1 (for gemcitabine); ERCC1 (for platinums); and TS (for 5FU). Pts with untreated, biopsiable MPC were eligible. Tissue biopsies were analyzed by Caris, and the results used to assign pts to 1 of 7 doublet regimens. Our 1 o objective was to provide preliminary data to inform a larger, randomized trial. Key 2 o objectives included assessment of the response rate (RR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS). Results: Between 12-2012 and 08-2014, 26 pts were enrolled. Eleven failed screening primarily due to inadequate tumor tissue availability (and pts not wanting to wait for a 2 nd biopsy). Of the 15 pts profiled, 6 different doublets were assigned, reflecting the breadth of profile results. Three pts were not evaluable for response by the date of this abstract. Of the 12 pts who received Tx, the RR was 9%, but the DCR rate was 82%. The median PFS and OS were 5.9 and 10.4 months, respectively. Conclusions: The incorporation of chemo biomarkers is feasible and resulted in a promising PFS and OS for pts with MPC. Our pilot experience suggests that there may be value to assessing a pt’s tumor molecular profile to select Tx. Expansion of this experience into a randomized trial of profile-directed Tx vs. Tx based on the physician’s discretion would not only be realistic, but could be critical to realizing the full, clinically meaningful benefit of molecular profiling. We do however caution that biomarker-directed Tx can be challenging in untreated pts, where initiation of Tx is time critical, and delays due to inadequate tumor samples may be untenable. Thus, a randomized trial in the second line setting may be more appropriate. Clinical trial information: NCT01888978.
Persistent psychophysiologic insomnia: preliminary Research Diagnostic Criteria and EEG sleep data
Authors: C F Reynolds, L S Taska, D E Sewitch, K Restifo, P A Coble, D J Kupfer
Journal: American Journal of Psychiatry (1984)

Some patients with persistent psychophysiologic insomnia have a history of generalized anxiety, minor depression, or drug misuse. Their sleep resembles sleep of patients with generalized anxiety (except for night 2 improvement in the insomniacs' sleep continuity) but differs from sleep of patients with major depression.
Human herpesvirus-8 DNA sequences in human immunodeficiency virus- negative angioimmunoblastic lymphadenopathy and benign lymphadenopathy with giant germinal center hyperplasia and increased vascularity
Authors: M Luppi, P Barozzi, A Maiorana, T Artusi, R Trovato, R Marasca, M Savarino, L Ceccherini-Nelli, G Torelli
Journal: Blood (1996)
A Modified Technique for Nerve-Sparing Retroperitoneal Lymph Node Dissection in Stage II Nonseminomatous Germ Cell Tumors Using Intraoperative Measurement of Bladder Neck Pressure Alterations following Sympathetic Nerve Fiber Electrostimulation
Authors: W Weidner, G Zöller, D Sauerwein, C Fischer, G Hummel, M Kallerhoff, R H Ringert
Journal: European Urology (1994)
Estimation of Relative Risk From Vital Data: Smoking and Cancers of the Lung and Bladder
Authors: Joan M. Davies
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Estimation of Relative Risk From Vital Data: Smoking and Cancers of the Lung and Bladder Get access Joan M. Davies Joan M. Davies Division of Epidemiology Institute of Cancer Research, Clifton Avenue, Sutton, Surrey SM2 5PX, England. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 66, Issue 4, April 1981, Pages 611–612, https://doi.org/10.1093/jnci/66.4.611 Published: 01 April 1981
Toxicity of Homologous Immune Serum to a Transplantable Tumor: Studies Using Phase Microscopy and Cinemicrography&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: R SCHREK, F W PRESTON
Journal: JNCI Journal of the National Cancer Institute (1956)

Toxicity of Homologous Immune Serum to a Transplantable Tumor: Studies Using Phase Microscopy and Cinemicrography2 Robert Schrek, Robert Schrek Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederick W. Preston Frederick W. Preston Search for other works by this author on: Oxford Academic PubMed Google Scholar 3The authors are indebted to Dr. Anna Goldfeder, who provided us with the Bagg tumor and to Dr. Kurt Stern for the Lewis lymphoma. Author Notes JNCI: Journal of the National Cancer Institute, Volume 16, Issue 4, February 1956, Pages 1021–1045, https://doi.org/10.1093/jnci/16.4.1021 Published: 01 February 1956 Article history Received: 29 August 1955 Published: 01 February 1956
Colonic ischaemia as a severe Shiga toxin/verotoxin producing Escherichia coli O104:H4 complication in a patient without haemolytic uraemic syndrome, Germany, June 2011
Authors: S Cordesmeyer, U Peitz, N Gödde, H U Kasper, M W Hoffmann, E Allemeyer
Journal: Eurosurveillance (2011)

An increasing rate of infections with Shiga toxin/verotoxin-producing Escherichia coli (STEC/VTEC) O104:H4 has been observed in Germany since May 2011, with unusually high numbers of patients suffering from haemolytic uraemic syndrome (HUS). We report a STEC/VTEC O104:H4 case without HUS, presenting with colonic ischaemia demanding surgery. This atypical clinical presentation of STEC O104:H4 infection might indicate new severe complications associated with this uncommon strain, and highlights the importance of immediate interdisciplinary assessment of STEC/VTEC patients.
Design of Cancer Assays for Pharmaceutical Agents: A Reply
Authors: G. A. Boorman, J. E. Huff, B. A. Schwetz
Journal: JNCI Journal of the National Cancer Institute (1986)

Design of Cancer Assays for Pharmaceutical Agents: A Reply Get access G. A. Boorman, G. A. Boorman Toxicology Research and Testing Program, National Institute of Environmental Health Sciences, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. E. Huff, J. E. Huff Toxicology Research and Testing Program, National Institute of Environmental Health Sciences, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar B. A. Schwetz B. A. Schwetz Toxicology Research and Testing Program, National Institute of Environmental Health Sciences, Public Health Service, U.S. Department of Health and Human Services, Research Triangle Park, North Carolina 27709 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 77, Issue 2, August 1986, Pages 589–590, https://doi.org/10.1093/jnci/77.2.589 Published: 01 August 1986
Multicenter Survey of Endoscopic Treatment of Vesicoureteral Reflux in Children
Authors: S. Geiss., P. Alessandrini, G. Allouch, D. Aubert, M. Bayard, J.M. Bondonny, J.P. Canarelli, Y. Chavrier, P. Delmas, H. Dodat, B. Fremont, B. Jehannin, A. Lacombe, Y. Melin, P. Montupet, P. Sauvage, C.C. Schulman, J. Valayer, J.S. Valla, C. Viville
Journal: European Urology (1990)
OC-091 Uk experience of endoscopic ultrasound (eus) guided pancreatic fluid collection (pfc) drainage: review of 100 consecutive cases
Authors: C Shekhar, C Forde, BS Mahon
Journal: Gut (2015)

<h3>Introduction</h3> Endoscopic ultrasound guided drainage is an effective, minimally invasive first line modality for the drainage of pancreatic fluid collection (PFC) resulting in a shorter hospital stay and less morbidity compared with surgical cystogastrostomy.<sup>1</sup>The revised Atlanta classification subdivides PFC more than 4 weeks old as either pancreatic pseudocyst (PP) or walled-off necrosis (WON).<sup>2</sup> <h3>Method</h3> Retrospective reveiw of 100 consecutive EUS guided drainages of PFC was undertaken utilising EUS reports; clinical notes and imaging with follow up to 12 months. <h3>Technique</h3> All procedures were undertaken under conscious sedation with EUS guidance alone (without fluoroscopy). After initial access, cystgastrostomy tract dilatation was carried with a 10F cystotome followed by balloon dilatation to 8 mm (6–15 mm) before placement of plastic double pigtail stents. <h3>Results</h3> All procedures were undertaken at least 4 weeks after acute pancreatitis (AP). Alcohol (35%) and gallstone (32%) were leading causes of AP. Pain, signs of infection, weight loss and early satiety were most frequent indications for drainage. Of 76 cases of PP and 24 of WON, drainage was successful in 94 patients after 1 procedure and a total of 96 patients after 2 procedures comprising of (97% (77/79) in PP and 92% (22/24) in WON). Sign/symptoms of infection were present in 4% (3/76) PP and 42% (10/24) WON. Median size of cyst was 9 cm (3–23 cm). All but one case (93/94) had successful placement of 2 (1–3) 7Fr stents. Median interval for stent removal was 7 months (3.5–12 months). Stents fell out spontaneously in 2 patients. Symptoms improvement and cyst resolutionwas achieved in 94% (89/94) cases. 9% (8/94; 6 PP and 2 WON) required 2 further EUS guided dilatation of the tract and additional stent insertion. Immediate complications included bleeding: 4% (4/94) of which 1 required endoscopic intervention whilst 3 were treated conservatively; infection 4% (4/94, 2 requiring external drain) and leak in peritoneal cavity 1% (1/94, requiring external drain). In 4% further intervention was required: 1 WON (surgery) and 3 PP (CT guided external drain). There were no cases of cyst recurrence after stent removal. <h3>Conclusion</h3> This is the largest series from a single UK centre demonstrating that EUS guided cystogastrostomy PFC drainage using plastic double pig tail stents is sufficient in high majority (96%) of cases with PFC including that of WON, with or without infection. It can be carried out under conscious sedation without propofol or general anaesthetic in the vast majority of cases with low morbidity. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Gastroenterology 2013;145(3):583–90 Gut 2013;62:102–111
Blue Macule on the Volar Surface of the Left Thumb—Quiz Case
Authors: Loren Zech, Norris Nolan, Scott A Norton
Journal: JAMA Dermatology (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
The Patient Himself
Authors: W SCHEIDT
Journal: JAMA (2020)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prediction of antidepressant responses to lithium
Authors: E F Donnelly, F K Goodwin, I N Waldman, D L Murphy
Journal: American Journal of Psychiatry (1978)

The authors studied 53 patients hospitalized for depression to evaluate possible associations between pretreatment responses to the Minnesota Multiphasic Personality Inventory and behaviorally rated responses to lithium. Patients were randomly assigned to two groups (A and B) in which responders and nonresponders were balanced for sex. For the 18 women in group A, a lithium response scale discriminated responders with 89% accuracy. For the 9 males, a separate scale discriminated responders with 100% accuracy. In a cross-validation, the two scales discriminated responders and nonresponders with 100% accuracy in group B. The empirical methodology of this study suggests an alternative to the theoretical-rational approach of predicting response to antidepressant drugs based on pretreatment depressive symptoms.
Clonal Analysis of Variant Cell Lines Transformed to Malignant Cells in Tissue Culture
Authors: Katherine K. Sanford, Ruth M. Merwin, Gwendolyn L. Hobbs, James M. Young, Wilton R. Earle
Journal: JNCI Journal of the National Cancer Institute (1959)

The following alternative interpretations of the difference between a low and high sarcoma-producing line of mouse cells derived in vitro from one cell of normal tissue origin have been examined: (1) The two lines might differ quantitatively in the proportion of malignant transplantable cells present in the cell populations. (2) Cells of the low line as compared with those of the high might possess entirely different heritable characteristics accounting for the low incidence of takes and the prolonged latent period for tumor development in vivo. A clonal analysis of the two populations has furnished evidence for the second interpretation. Five single cells from the low and high lines duplicated in their derived clones most of the characteristic properties of the line from which each originated, including the characteristic rate of tumor formation in vivo. Some differences between clones from the same line were also observed, revealing variations or potentialities for further change among individual components of the cell population. In addition, the type of culture medium was an important factor influencing the transplantability of tissue-culture cells to animals of the inbred strain of origin. The importance of transplantation for detecting the malignant conversion of cells in vitro, factors influencing the transplantability of tissue-culture cells, possible causes of the malignant transformation of cells in vitro, and interpretations of the differences between these cell lines and clones are discussed.