tbuckley/cabot-search huggingface dataset:
Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges
Authors: Wei‐Lin Jin, Xiao‐Yuan Mao, Guan‐Zhong Qiu
Journal: Medicinal Research Reviews (2016)

Abstract Glioblastoma (GBM) is regarded as the most common primary intracranial neoplasm. Despite standard treatment with tumor resection and radiochemotherapy, the outcome remains gloomy. It is evident that a combination of oncogenic gain of function and tumor‐suppressive loss of function has been attributed to glioma initiation and progression. The ubiquitin–proteasome system is a well‐orchestrated system that controls the fate of most proteins by striking a dynamic balance between ubiquitination and deubiquitination of substrates, having a profound influence on the modulation of oncoproteins, tumor suppressors, and cellular signaling pathways. In recent years, deubiquitinating enzymes (DUBs) have emerged as potential anti‐cancer targets due to their targeting several key proteins involved in the regulation of tumorigenesis, apoptosis, senescence, and autophagy. This review attempts to summarize recent studies of GBM‐associated DUBs, their roles in various cellular processes, and discuss the relation between DUBs deregulation and gliomagenesis, especially how DUBs regulate glioma stem cells pluripotency, microenvironment, and resistance of radiation and chemotherapy through core stem‐cell transcriptional factors. We also review recent achievements and progress in the development of potent and selective reversible inhibitors of DUBs, and attempted to find a potential GBM treatment by DUBs intervention.
TCT-572 Use of Intravascular Imaging During Chronic Total Occlusion Percutaneous Coronary Intervention: Insights from a Contemporary Multicenter Registry
Authors: Judit Karacsonyi, Khaldoon Alaswad, Farouc Jaffer, Robert Yeh, Mitul Patel, John Bahadorani, Barbara Anna Danek, Aris Karatasakis, Anthony Doing, J. Aaron Grantham, Dimitri Karmpaliotis, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, William Lombardi, David Kandzari, Nicholas Lembo, Santiago Garcia, R. Michael Wyman, Aya Alame, Jose Roberto Martinez-Parachini, Phuong-Khanh Nguyen-Trong, Erica Resendes, Pratik Kalsaria, Bavana Rangan, Imre Ungi, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2016)
TCT-231 The Glasgow Trans-radial Rotablation Registry – A Retrospective Analysis of High-speed Rotational Atherectomy
Authors: Alice Jackson, Kieran Docherty, Jim Christie, Mitchell Lindsay, Keith Oldroyd, Stuart Watkins, Aadil Shaukat, Colin Berry, Keith Robertson, Richard Good, Mark Petrie, Stuart Hood, Andrew Davie, Hany Eteiba, Margaret McEntegart, John Paul Rocchiccioli
Journal: Journal of the American College of Cardiology (2016)
Fetal Vs. Adult Hematopoietic Progenitors Respond Differently to NOTCH1: Implications for Pediatric Vs. Adult T-ALL.
Authors: Vincenzo Giambra, Sonya H Lam, Amy Ng, Claudia Benz, Olena O Shevchuk, Connie J. Eaves, Andrew P Weng
Journal: Blood (2012)
Visualization, Quantification and Characterization of Caerulein-Induced Acute Pancreatitis in Rats by 3.0T Clinical MRI, Biochemistry and Histomorphology
Authors: Ting Yin, Ronald Peeters, Yewei Liu, Yuanbo Feng, Xinyuan Zhang, Yansheng Jiang, Jie Yu, Steven Dymarkowski, Uwe Himmelreich, Raymond Oyen, Yicheng Ni
Journal: Theranostics (2016)

Purpose: To investigate whether Caerulein-induced acute pancreatitis (AP) in rats could be noninvasively studied by clinical magnetic resonance imaging (MRI) techniques and validated by enzymatic biochemistry and histomorphology. Materials and Methods: The study was approved by the institutional animal ethical committee. The AP was induced in 26 rats by intraperitoneal injections of Caerulein, as compared to 6 normal rats. T2-weighted 3D MRI, T2 relaxation measurement and contrast enhanced T1-weighted MRI were performed at 3 Tesla. Pancreatic volume and contrast ratio of pancreas against surrounding tissues were measured by MRI. Animals were scarified at 3, 8, 24 and 48-hr respectively for analyses of serum lipase and amylase levels, and biliopancreatic perfusion-assisted histomorphology. Results: The AP could be observed on MRI 3-hr onwards after Caerulein-administration. T2 relaxation within the pancreas was prolonged due to high water content or edema. Increase of vascular permeability was indicated by T1 contrast enhancement. Both edema and vascular permeability gradually recovered afterwards (p<0.05/0.01), paralleled by declining serum enzyme levels (p<0.05). Microscopy revealed cell vacuolization and edema for early stage, and increased inflammatory cell infiltration and acinar cell loss after 24 and 48-hr. Conclusion: Multiparametric MRI techniques at 3.0T could facilitate noninvasive diagnosis and characterization of Caerulein induced AP in rats, as validated by a novel ex vivo method.
TCT-440 Impact of optimal implantation technique on bioresorbable scaffold expansion and one-year clinical outcomes in patients presenting with acute coronary syndromes and calcified lesions. A pooled analysis of BVS STEMI First and BVS Expand Studies
Authors: Mariusz Tomaniak, Cordula Felix, Jiang Ming Fam, Robert-Jan van Geuns, Nicolas Van Mieghem, Evelyn Regar, Joost Daemen, Felix Zijlstra, Roberto Diletti
Journal: Journal of the American College of Cardiology (2016)
TCT-281 Development and Validation of a Scoring System for Predicting Major Adverse Cardiovascular Events during Percutaneous Coronary Interventions of Chronic Total Occlusions: The PROGRESS CTO (Prospective Global Registry for the Study of Chronic Total Occlusion Intervention) MACE Score
Authors: Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R. Michael Wyman, J. Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2016)
TCT-677 Comparison of surgical versus interventional treatment of aortic valve stenosis in kidney transplant recipients
Authors: Stefan Büttner, Helge Weiler, Carolin Zöller, Sammy Patyna, Jörg Honold, Nestoras Papadopoulos, Helmut Geiger, Ingeborg A. Hauser, Mariuca Vasa-Nicotera, Stephan Fichtlscherer
Journal: Journal of the American College of Cardiology (2016)
Effect of the third generation selective estrogen receptor modulator arzoxifene on mammographic breast density
Authors: B. F. Kimler, G. Ursin, C. J. Fabian, J. R. Anderson, C. Chamberlain, M. S. Mayo, J. A. O’Shaughnessy, H. T. Lynch, K. A. Johnson, D. Browne
Journal: Journal of Clinical Oncology (2006)

562 Background: Arzoxifene (ARZ) is currently being studied for treatment of breast cancer patients in a Phase II trial because of tamoxifen-like efficacy but lack of uterine agonist effect. We conducted a Phase II chemoprevention trial in women at high risk for development of breast cancer on the basis of personal or family history. Methods: Potential subjects had multiple biomarkers assessed, including random periareolar fine needle aspiration (RPFNA) with breast epithelial cells processed for cytomorphology and immunocytochemistry. Women who exhibited cytologic hyperplasia ± atypia were eligible for enrollment. Subjects were stratified on the basis of atypia, estrogen receptor expression, menopause status, germline BrCa1/2 mutation status, and accrual site. Subjects were randomized (double-blind) between placebo and ARZ (LY353381.HCI, 20 mg daily) for 6 mo, with an option to continue on study for another 6 mo while receiving open-label ARZ. Assessments conducted at baseline, 6 mo, and 12 mo included mammographic breast density. Mammograms were digitized to image files which were cropped to remove labels and dates, and then identified by a study subject ID number and a random coding for baseline, 6 or 12 mo. This allowed the reader (GU) to view the three files for a subject, but to remain blinded as to the sequence of the films or the study agent. The files were assessed for mammographic density using the Madena computer-assisted system. Results: Of 199 subjects enrolled on the study, 52% were pre-menopausal; with 101 women randomized to placebo and 98 to ARZ. At baseline, mean values were comparable for placebo and ARZ groups for breast area (∼244 cm 2 ), total dense area (∼100 cm 2 ), and the percent of the breast at increased density (41.3% vs 46.2%). After 6 mo, there were minimal changes in total breast area (P=0.13); but statistically significant decreases (P&lt;0.001) for the comparison of placebo vs ARZ (2-sided T-test) for change in both dense area (+3.8 vs −12.9 cm 2 ) and percent breast density (+0.8% vs −4.6%). Conclusions: The 3rd generation SERM arzoxifene administered for 6 mo produces statistically significant decreases in mammographic breast density relative to placebo in women at high risk for development of breast cancer. No significant financial relationships to disclose.
TCT-188 The impact of the location on left ventricular function in ST-elevation Myocardial Infarction patients with a chronic total occlusion in a non-infarct related artery treated with percutaneous coronary intervention
Authors: Joelle Elias, Ivo van Dongen, Loes Hoebers, Dagmar Ouweneel, Bimmer Claessen, Jose Henriques
Journal: Journal of the American College of Cardiology (2016)
TCT-206 Tailoring the Intensity of Antiplatelet Pharmacotherapy to Ischemic and Bleeding Risk: A Cost Optimizing Simulation From PARIS
Authors: Daniel Leisman, Usman Baber, David Cohen, C. Michael Gibson, Stuart Pocock, Timothy Henry, Philippe Gabriel Steg, George Dangas, David Moliterno, Bernhard Witzenbichler, Annapoorna Kini, Mitchell Krucoff, Jeffrey Bruckel, Antonio Colombo, Alaide Chieffo, Roxana Mehran
Journal: Journal of the American College of Cardiology (2016)
TCT-46 Coronary artery aneurysms: incididence, etiology, management and outcomes in a long-term follow up.
Authors: Santiago Jesús Camacho Freire, Antonio Gomez Menchero, Javier Leon Jimenez, Hany Tawfik, JESSICA ROA-GARRIDO, ROSAMARIACARDENAL PIRIS, PRUDENCIAGMEZ FERNANDEZ, Francisco Javier Landero Garcia, J.F. Diaz Fernandez
Journal: Journal of the American College of Cardiology (2016)
TCT-312 Increased Cardiac Death and Stent Thrombosis in Chronic Obstructive Pulmonary Disease Patients Undergoing Percutaneous Coronary Intervention. An analysis of the BASKET-PROVE I and II trials
Authors: Tannas Jatene, Tor Biering-Sørensen, Kotaro Nochioka, Fernanda Mangione, Kim Hansen, Rikke Sørensen, Jan Skov Jensen, Peter Jørgensen, Raban Jeger, Christoph Kaiser, Matthias Pfisterer, Soeren Galatius
Journal: Journal of the American College of Cardiology (2016)
¿CÓMO INFLUYE EL INTERVALO DE TIEMPO DE SEGUIMIENTO EN PACIENTES DE ALTO RIESGO DE CANCER COLORRECTAL EN UN PROGRAMA DE CRIBADO? UN ESTUDIO DE SUPERVIVENCIA
Authors: B Martínez Andrés, JF Sánchez-Melgarejo, JM Rubio Mateos, E Torrella Cortés, S Chacón Martínez, P Bebia Conesa, JL Rodrigo Agudo, F Pérez-Riquelme, E Pérez-Cuadrado Martínez, E Pérez-Cuadrado Robles
Journal: Endoscopy (2016)

Introducción: Las guías de cribado de cáncer colorrectal han ido modificando el intervalo de seguimiento tras la colonoscopia inicial en base a sus hallazgos. Además, en la práctica clínica, la lista de espera y condicionantes individuales modifican los mismos. Las últimas guías europeas establecen un seguimiento a 3 años si ≥3 adenomas y/o ≥10 mm (alto riesgo).
TCT-403 Bioresorbable Coronary Devices in Bifurcations: Immediate and 6-month Results of the REPARA Registry
Authors: Felipe Hernandez, Jose M. de la Torre Hernandez, Bruno Garcia, Jose Rumoroso, Ramiro Trillo, Armando Perez de Prado, eduardo molina, Raul Moreno, Jose Diaz, Ivan Gomez Blazquez, Hipolito Gutierrez, Pedro Canas da Silva, Vasco Gama Ribeiro
Journal: Journal of the American College of Cardiology (2016)
TCT-84 Outcomes of Transcatheter Aortic Valve Replacement without predilation of the aortic valve: Insights from 1942 patients included in the SOURCE 3 Registry
Authors: Nicolas Dumonteil, Thomas Walther, Frederic Pinaud, Christian Terkelsen, Christian Frerker, Frederic Collart, Jochen Wöhrle, Stephan Windecker, Christian Butter, Leo Ihlberg
Journal: Journal of the American College of Cardiology (2016)
Bortezomib, Pegylated-Lyposomal-Doxorubicin and Dexamethasone Followed by Melphalan 100 mg/m2 in Elderly Newly Diagnosed Patients: An Interim Analysis.
Authors: Antonio Palumbo, Ilaria Avonto, Francesca Patriarca, Claudia Crippa, Maria T. Petrucci, Fausto Rossini, Paolo Corradini, Anna M. Liberati, Nicola Giuliani, Norbert Pescosta, Patrizia Falco, Alessandra Larocca, Paola Omedè, Massimo Offidani, Renato Fanin, Mario Boccadoro
Journal: Blood (2007)
Rituximab in CD20 Positive Multiple Myeloma: A Prospective Study from the IFM Group.
Authors: Philippe Moreau, Laurent Voillat, Lotfi Benboubker, Charles Dumontet, Claire Mathiot, Cyrille Hulin, Nelly Robillard, Herve Avet Loiseau, Olivier Herault, Francine Garnache, Nathalie Varoqueaux, Jean-luc Harousseau, Regis Bataille
Journal: Blood (2006)
EFICACIA Y SEGURIDAD DE LA FISTULOTOMÍA BILIAR EN LA CANULACIÓN BILIAR SELECTIVA EN CASOS DE CANULACIÓN DIFÍCIL
Authors: D Martínez-Ares, J Ramada, A Parente, P Sousa, F Pinto, A Cadeco, L Lopes
Journal: Endoscopy (2016)

Aunque la canulación selectiva de la vía biliar principal (VBP) es un paso fundamental para la realización de la CPRE puede ser fallida hasta en un 15% de casos. La fistulotomía realizada con esfinterotomo de aguja puede ser una alternativa en estos casos, aunque varios estudios le consideran el como factor de riesgo independiente de pancreatitis post-CPRE.
The Novel Small Molecule Chk1/Chk2 Inhibitor PF-0477736 (Pfizer) Is Highly Active As Single Agent in Philadelphia-Positive Acute Lymphoblastic Leukemia (Ph+ ALL)
Authors: Ilaria Iacobucci, Federica Cattina, Silvia Pomella, Annalisa Lonetti, Enrico Derenzini, Elisa Brighenti, Anna Ferrari, Cristina Papayannidis, Maria Vittoria Verga Falzacappa, Viviana Guadagnuolo, Michela Aluigi, Emanuela Ottaviani, Serena Formica, Maria Chiara Abbenante, Simona Soverini, Domenico Russo, Fabrizio Pane, Pier Guiseppe Pellicci, Michele Baccarani, Giovanni Martinelli
Journal: Blood (2011)
Integrating a prospective pilot trial and patient-derived xenografts to trace metabolic changes associated with acute myeloid leukemia
Authors: Matteo G. Carrabba, Laurette Tavel, Giacomo Oliveira, Alessandra Forcina, Giacomo Quilici, Francesca Nardelli, Cristina Tresoldi, Alessandro Ambrosi, Fabio Ciceri, Massimo Bernardi, Luca Vago, Giovanna Musco
Journal: Journal of Hematology & Oncology (2016)

Despite the considerable progress in understanding the molecular bases of acute myeloid leukemia (AML), new tools to link disease biology to the unpredictable patient clinical course are still needed. Herein, high-throughput metabolomics, combined with the other "-omics" disciplines, holds promise in identifying disease-specific and clinically relevant features. In this study, we took advantage of nuclear magnetic resonance (NMR) to trace AML-associated metabolic trajectory employing two complementary strategies. On the one hand, we performed a prospective observational clinical trial to identify metabolic changes associated with blast clearance during the first two cycles of intensive chemotherapy in nine adult patients. On the other hand, to reduce the intrinsic variability associated with human samples and AML genetic heterogeneity, we analyzed the metabolic changes in the plasma of immunocompromised mice upon engraftment of primary human AML blasts. Combining the two longitudinal approaches, we narrowed our screen to seven common metabolites, for which we observed a mirror-like trajectory in mice and humans, tracing AML progression and remission, respectively. We interpreted this set of metabolites as a dynamic fingerprint of AML evolution. Overall, these NMR-based metabolomic data, to be consolidated in larger cohorts and integrated in more comprehensive system biology approaches, hold promise for providing valuable and non-redundant information on the systemic effects of leukemia.
TCT-698 Comparison of the fully repositionable and retrievable Lotus Valve and Direct Flow Medical Valve for the treatment of severe aortic stenosis: a high-volume single center experience
Authors: Francesco Giannini, Azeem Latib, Matteo Montorfano, Neil Ruparelia, Vittorio Romano, Matteo Longoni, Andrea Aurelio, Richard Jabbour, Damiano Regazzoli, Luca Angelo Ferri, Antonio Mangieri, Marco Ancona, Akihito Tanaka, Eustachio Agricola, Alaide Chieffo, Ottavio Alfieri, Antonio Colombo
Journal: Journal of the American College of Cardiology (2016)
TCT-683 A Meta-analysis and Meta-regression of Long-Term Outcomes of Transcatheter versus Surgical Aortic Valve Replacement for Severe Aortic Stenosis
Authors: Pedro Villablanca, Mohammed Makkiya, Verghese Mathew, Vinod Thourani, Josep Rodés-Cabau, Sripal Bangalore, Peter Vlismas, David Briceno, David Slovut, Cynthia Taub, Patrick McCarthy, John Augoustides, Harish Ramakrishna
Journal: Journal of the American College of Cardiology (2016)
Asthma attacks: should we nail our colours to the mast (cell)?
Authors: Louise Fleming, Sejal Saglani, Andrew Bush
Journal: European Respiratory Journal (2016)

Many common airway diseases are characterised by chronic symptoms with interspersed acute and unpredictable deteriorations, conventionally called “pulmonary exacerbations”. Until relatively recently, these so-called exacerbations were a rather Cinderella subject, relatively neglected in favour of treating day-to-day problems. This may in part be because in asthma, for example, we have treatments such as inhaled corticosteroids (ICS) which are enormously effective in treating chronic symptoms, but prevention of exacerbations is much less successful. However, it is becoming increasingly clear that pulmonary exacerbations carry much more sinister overtones than once we thought, to the extent that the term “lung attacks” has been proposed to describe them [1, 2]. In cystic fibrosis (CF), treatment of lung attacks even with intravenous antibiotics may fail to restore spirometry to baseline [3], and are associated with an accelerated decline in lung function [4] and a worse prognosis [5]. Failure of response is also described in primary ciliary dyskinesia [6]. Lung attacks, as we shall continue to describe them, have been used as clinical trial end-points in CF [7] and bronchiectasis [8], and may be a more sensitive marker of response than spirometry [9]. They are very far from being a minor and reversible inconvenience to the patient with airways disease. Why do only some asthmatic children exacerbate, what is the underlying pathology, and how should we treat them? <http://ow.ly/Mrik304eIVU>
Talpid Mole Phylogeny Unites Shrew Moles and Illuminates Overlooked Cryptic Species Diversity
Authors: Kai He, Akio Shinohara, Kristofer M. Helgen, Mark S. Springer, Xue-Long Jiang, Kevin L. Campbell
Journal: Molecular Biology and Evolution (2016)

The mammalian family Talpidae (moles, shrew moles, desmans) is characterized by diverse ecomorphologies associated with terrestrial, semi-aquatic, semi-fossorial, fossorial, and aquatic-fossorial lifestyles. Prominent specializations involved with these different lifestyles, and the transitions between them, pose outstanding questions regarding the evolutionary history within the family, not only for living but also for fossil taxa. Here, we investigate the phylogenetic relationships, divergence times, and biogeographic history of the family using 19 nuclear and 2 mitochondrial genes (∼16 kb) from ∼60% of described species representing all 17 genera. Our phylogenetic analyses help settle classical questions in the evolution of moles, identify an ancient (mid-Miocene) split within the monotypic genus Scaptonyx, and indicate that talpid species richness may be nearly 30% higher than previously recognized. Our results also uniformly support the monophyly of long-tailed moles with the two shrew mole tribes and confirm that the Gansu mole is the sole living Asian member of an otherwise North American radiation. Finally, we provide evidence that aquatic specializations within the tribes Condylurini and Desmanini evolved along different morphological trajectories, though we were unable to statistically reject monophyly of the strictly fossorial tribes Talpini and Scalopini.
Enhanced Detection of Cancer Biomarkers in Blood-Borne Extracellular Vesicles Using Nanodroplets and Focused Ultrasound
Authors: Robert J. Paproski, Juan Jovel, Gane Ka-Shu Wong, John D. Lewis, Roger J. Zemp
Journal: Cancer Research (2016)

Abstract The feasibility of personalized medicine approaches will be greatly improved by the development of noninvasive methods to interrogate tumor biology. Extracellular vesicles shed by solid tumors into the bloodstream have been under recent investigation as a source of tumor-derived biomarkers such as proteins and nucleic acids. We report here an approach using submicrometer perfluorobutane nanodroplets and focused ultrasound to enhance the release of extracellular vesicles from specific locations in tumors into the blood. The released extracellular vesicles were enumerated and characterized using micro flow cytometry. Only in the presence of nanodroplets could ultrasound release appreciable levels of tumor-derived vesicles into the blood. Sonication of HT1080-GFP tumors did not increase the number of circulating tumor cells or the metastatic burden in the tumor-bearing embryos. A variety of biological molecules were successfully detected in tumor-derived extracellular vesicles, including cancer-associated proteins, mRNAs, and miRNAs. Sonication of xenograft HT1080 fibrosarcoma tumors released extracellular vesicles that contained detectable RAC1 mRNA with the highly tumorigenic N92I mutation known to exist in HT1080 cells. Deep sequencing serum samples of embryos with sonicated tumors allowed the identification of an additional 13 known heterozygous mutations in HT1080 cells. Applying ultrasound to HT1080 tumors increased tumor-derived DNA in the serum by two orders of magnitude. This work is the first demonstration of enhanced extracellular vesicle release by ultrasound stimulation and suggests that nanodroplets/ultrasound offers promise for genetic profiling of tumor phenotype and aggressiveness by stimulating the release of extracellular vesicles. Cancer Res; 77(1); 3–13. ©2016 AACR.
Shorter regimen for multi drug resistant tuberculosis cures more than 80% of patients
Authors: Sophie Cousins
Journal: BMJ (2016)

A nine month treatment regimen for multiple drug resistant tuberculosis (MDR-TB) patients across nine African countries has shown a success rate of more than 80%, according to results announced at the World Conference on Lung Health in Liverpool, UK.

The results give further impetus for the shortened treatment regimen to be widely adopted, those involved with the study said.

The previous standard regimen for treating MDR-TB lasted for at least 20 months and had a cure rate of less than 55%, often with severe side effects including hearing loss. The treatment consisted …
Cell Engineering with Glycogen Synthase Kinase-3 Beta Inhibitor-Loaded Synthetic Nanoparticles Enhances Hematopoietic Engraftment of Bone Marrow Mononuclear Cells Following in Utero Transplantation
Authors: Stavros P Loukogeorgakis, Haiying Li, Li Tang, Aimee G Kim, Jesse D Vrecenak, Ilana Nissim, Michael A Conner, Izhtak Nissim, Paolo De Coppi, William Peranteau, Darrell J Irvine, Alan W Flake
Journal: Blood (2014)
HSP70 Inhibitor, YK5, Synergizes with Chemotherapeutic Agents and Prevents Chemoresistance in Acute Myelogenous Leukemia (AML).
Authors: Krishan K. Sharma, Juan Felipe Rico, Michael W. Becker, Gail J. Roboz, Gabriela Chiosis, Monica L. Guzman
Journal: Blood (2012)