tbuckley/cabot-search huggingface dataset:
OP0165 Subfertility in Female Rheumatoid Arthritis Patients is Often Unexplained or Caused by Anovulation
Authors: J. Brouwer, R. Fleurbaaij, J.M. Hazes, J.S. Laven, R.J. Dolhain
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Subfertility is an important problem in younger female rheumatoid arthritis (RA) patients. Approximately 40% of these women have a time to pregnancy longer than 12 months, or do not get pregnant at all. This percentage is considerably higher than in the general population. Active disease and anti-rheumatic treatment have been shown to be associated with a reduced fertility in women with RA.(1) However, results of gynecological work-up in these women have not been reported in literature thus far. <h3>Objectives</h3> To study the outcomes of fertility work-up in female RA patients. <h3>Methods</h3> A cross-sectional study was performed in participants of a nationwide cohort of female RA patients who were pregnant or tried to conceive in 2002-2008 (PARA study).(2) All patients who had given consent for future contact (n=260) were sent a questionnaire on their reproductive history, visits to their gynecologist, fertility work-up and fertility treatments. Medical files were obtained from attending gynecologists to study diagnoses and performed fertility treatments. <h3>Results</h3> A completed questionnaire was returned by 178 women (69%). The current age was 40.5±4.2 years. Most women (96%) had ended their efforts to conceive. Eighty-two subjects (46%) had at least one subfertile episode, and 56% of these patients were subfertile throughout their complete reproductive history. Subfertile women with RA had significantly less pregnancies and less children than fertile RA patients. In subfertile women, 50% (n=68) conceived at least once with the help of a fertility treatment, accounting for 17% of all pregnancies in the cohort. Sixty-four (78%) of the subfertile women gave their consent for obtaining medical files from their attending gynecologist. Gynecological diagnoses (n=61) included: unexplained subfertility (41%), anovulation (27%), male subfertility (16%), endometriosis (6%) and other factors (all &lt;5%). <h3>Conclusions</h3> Unexplained subfertility and anovulation are the most common diagnoses in subfertile female RA patients. Especially unexplained subfertility is diagnosed more often than in the general subfertile population. Therefore, it is likely that RA related factors, such as severity of the disease, inflammation, and the use of anti-rheumatic drugs, are involved in subfertility in women with RA. <h3>References</h3> Brouwer J, Hazes JM, Laven JS, Dolhain RJ. Fertility in women with rheumatoid arthritis: Influence of disease activity and medication. Ann Rheum Dis 2014. de Man YA, Dolhain RJ, van de Geijn FE, Willemsen SP, Hazes JM. Disease activity of rheumatoid arthritis during pregnancy: Results from a nationwide prospective study. Arthritis Rheum 2008;59:1241-8. <h3>Acknowledgements</h3> This study is funded by the Dutch Arthritis Foundation (Reumafonds). <h3>Disclosure of Interest</h3> None declared
ETHICS OF A PROTESTANT PHYSICIAN
Authors: J H TALBOTT
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0875 Role of Physical Therapy in Management of Knee Osteoarthritis: Table 1
Authors: L. Metoui, R. Dhahri, N. Boussetta, F. Laajili, N. Ben Abdelhafidh, B. Louzir, I. Gharsallah, S. Othmeni, I. Ksibi, R. Maaouia, A. Aouadi, H. Rahali
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Physical therapists provide a variety of interventions, such as manual therapy techniques, balance, coordination, and functional retraining techniques, knee taping techniques, electrical stimulation, and foot orthotics to assist in overcoming some of the barriers that make participation in exercise and physical activity difficult. <h3>Objectives</h3> This study aimed to assess the role of physical therapy in management of knee osteoarthritis on both levels pain and function. <h3>Methods</h3> Retrospective longitudinal study done on the department of Physical and Rehabilitation Medicine of the Principal Military Hospital of Tunis between January 2011 and December 2012, about 60 patients with knee OA. These patients were divided into two groups of 30 cases: patients aged 65 years and over (SA) and young adults 30 to 55 years (SJ). The evaluation protocol included clinical algofunctional before and after medical and rehabilitative treatment performed on an outpatient program with three sessions per week for two months. <h3>Results</h3> There were 35 women and 25 men with a mean age of 58±6.27 years. The average duration of knee OA was 63.74±38.62 months. The main characteristics of elderly subjects compared to young subjects, before rehabilitation, were the bilateral involvement of the knees (p=0.02), severity of pain (p=0.02), disability (p=0.006), stiffness (p=0.02), muscle weakness of the quadriceps (p=0.006), hamstrings (p=0.03), the retraction of the latter (p=0.04) and reducing the walking distance (p=0.04). 38 patients (19 and 19 SA SJ) adhered to the rehabilitation program. After rehabilitation, the main features were the reduction of pain by 60%, improving activities of daily life of 50%. The rehabilitative treatment was more effective in the elderly in terms of pain (p=0.03) and activities of daily living improvement (p=0.01). Patients in both groups improved their scores with no significant differences related to age. Considering respectively the VAS pain (p=0.48), WOMAC index (p=0.39) and LEQUESNE Index (p=0.75). At the end of the rehabilitation program, a reduction in pain intensity was observed in all AS (19 cases), 13 of them have lowered their VAS pain threshold of less than 50 mm. In young subjects, the pain remained stationary in 2 cases and was exacerbated in one case. <h3>Conclusions</h3> Physical therapy appears to be an important tool for KOA management. Future studies are needed to improve our understanding of factors that can influence the responsiveness of patients with knee osteoarthritis to exercise and physical activity programs. <h3>Disclosure of Interest</h3> None declared
Investigation of a tuberculosis cluster at a job centre in Manchester, United Kingdom
Authors: A Kirkpatrick, C Bell, M Petrovic, M Woodhead, A Barrett, E Duffell, A Verma, F Reynolds
Journal: Eurosurveillance (2006)

During the summer of 2005, four cases of active tuberculosis from the same occupational setting were investigated in Manchester, UK. The index case had been diagnosed in December of the previous year. At that stage the closest occupational contacts had been screened, all of whom were assessed as being free from active disease, and none had met nationally recommended criteria for chemoprophylaxis for latent tuberculosis infection (LTBI). In June 2005, two work contacts developed progressive primary extrapulmonary (pleural) TB. Following a detailed risk assessment, the screening programme was widened to include 137 staff who worked at the job centre (employment agency) where the first four cases had been found. This screening programme was based on tuberculin Mantoux testing, CXR and gamma-interferon testing. Of these 137 contacts screened, one additional person was found to have active disease and six others were offered chemoprophylaxis for LTBI. The isolates from the index case and the first two secondary cases were indistinguishable on VNTR-MIRU (variable number tandem repeat - mycobacterial interspersed repetitive unit) typing at 15 loci. No samples were available for testing from the fourth case of active disease. Management of this incident has benefited from the evolving fields of both genotyping and diagnostic testing for LTBI. However, further research into the epidemiological inferences made through genotyping, as well as the significance of a positive gamma-interferon test in assessing the risk of development of active disease, is still required.
NHS money is wasted on short term action rather than fixing the underlying problems
Authors: S. Black
Journal: BMJ (2015)

The Blair government doubled the budget, but that didn’t keep deficits away for long. Scotland abolished the commissioner-provider split but that didn’t yield better performance or 14% more money.1 Top-down changes and mergers don’t seem to help.2 3 4

This failure of top-down initiatives points …
Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments (vol 57, pg 475, 2008)
Authors: Peter D Fairclough
Journal: Gut (2008)

Edited by J Cohen. . Published by Blackwell, Oxford, 2007, pp 317, hardcover with DVD, £110. ISBN 9781405158862

Narrow band imaging (NBI) comes as standard with the latest version of the hardware sold by the UK’s most popular supplier of endoscopy equipment, but how many UK gastroenterologists know the theory of the new modality, how to use it, the appearances of even common lesions and the potential benefits for patients? This book attempts to bring the experience of the (mostly Japanese) front runners in NBI to a more general audience.

NBI uses restricted parts of the spectrum of white light to enhance the vessel pattern and superficial detail of mucosal lesions, allowing the diagnosis of early lesions such as cancers and dysplasia, so poor in current UK …
A Latin American perspective on DSM-III
Authors: R D Alarcon
Journal: American Journal of Psychiatry (1983)

The author examines some of the basic postulates and initial accomplishments of DSM-III from a Latin American vantage point. The phenomenological approach taken by DSM-III has enjoyed a long and prestigious tradition in Latin America. The author cites some of the difficulties posed by the personality disorders section, the exclusion of cultural criteria and psychocultural syndromes, and the practical inapplicability of the axis IV and V specifications for Latin American patients. DSM-III, however, is a challenging stimulus for Latin American and Third World psychiatrists and a real test for the influence and consistency of American psychiatry across the world.
Mad or bad? some clinical considerations in the misdiagnosis of schizophrenia as antisocial personality disorder
Authors: S Travin, B Protter
Journal: American Journal of Psychiatry (1982)

Some clinicians tend to misdiagnose schizophrenia when there is accompanying antisocial behavior, thus depriving the patient of appropriate treatment. Four factors appear to contribute to this misdiagnosis, the most important of which is the nature of the interaction between examiner and examinee. The authors present a case illustration and discuss the implications for treatment.
P2-124: Focal adhesion paxillin induces nodular cell growth, invasion, and angiogenesis in lung cancer
Authors: Ramasamy Jagadeeswaran, Osvaldo Zumba, Soundararajan Krishnaswamy, Varalakshmi Janamanchi, Tanguy Y. Seiwert, Sivakumar Loganathan, Rajani Kanteti, Vidya Nallasura, Leonardo Faoro, Everett E. Vokes, Ravi Salgia
Journal: Journal of Thoracic Oncology (2007)
FRI0594 Is Lymphocytic Sialadenitis IGG4-Related? An Observational Study
Authors: N. Chavarot, M. Hourseau, T. Papo, K. Sacre
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> IgG4-related disease is a systemic fibroinflammatory condition characterized by a dense IgG4-positive lymphoplasmocytic infiltrate in involved organs. Salivary gland is one of the most common sites of the disease and, besides submandibular and parotid glands, minor lip salivary glands involvement has been described <h3>Objectives</h3> The main objective of our study was to determine the prevalence of IgG4-related disease among patients with well-defined lymphocytic sialadenitis on labial salivary gland biopsy <h3>Methods</h3> All labial salivary gland biopsies (LSGB) performed in a French University Hospital Center over a one-year period were retrospectively screened. IgG4 immunostaining was performed on all LSGB showing lymphocytic sialadenitis defined by a Chisholm score ≥3. Histopathological criteria for IgG4-related disease according to international criteria and final diagnosis associated with lymphocytic sialadenitis were analyzed in all cases. <h3>Results</h3> Three hundred and fifty patients had a labial salivary gland biopsy (LSGB). Among them, 79 (23%) had a lymphocytic sialadenitis. Mean age was of 55.5±15.7 years old. Female/Male Sex ratio was 3.2/1. LSGB was performed because of sicca symptoms in most cases (48/79, 60.8%). Only one (1/79, 1.3%) LSGB showed histopathological features of IgG4-related disease in a patient who otherwise displayed obvious extra-salivary features of IgG4-related disease. Overall, the diagnoses associated with lymphocytic sialadenitis were Sjögren9s syndrome (29/79, 36.7%), other autoimmune disorders (besides Sjogren9s syndrome) (17/79, 21.5%), idiopathic pulmonary fibrosis (5/79, 6.3%), sarcoidosis (3/79, 3.8%), B-cell hemopathy (3/79, 3.8%), hepatitis C infection (2/79, 2.5%), unclassified arthritis (1/79, 1.3%), idiopathic uveitis (1/79, 1.3%), multiple sclerosis (1/79, 1.3%) and tuberculosis (1/79, 1.3%). In 15 cases (19%), no diagnosis could be obtained despite extensive work-up. Of note, IgG4 staining was negative in all patients with unexplained lymphocytic sialadenitis. <h3>Conclusions</h3> The prevalence of IgG4-related disease among patients with lymphocytic sialadenitis on LSGB is very low. Hence, IgG4 immunostaining has a poor diagnostic yield and should not be systematically performed in lymphocytic sialadenitis. On the other hand, LSGB, by being simple and safe, can be useful for a definite diagnosis when IgG4-related disease is suspected <h3>Disclosure of Interest</h3> None declared
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia
Authors: M Z Wamboldt, N H Kalin, S J Weiler
Journal: American Journal of Psychiatry (1985)

The authors present a longitudinal case study of a 57-year-old man whose initial symptoms consisted of depression and dementia associated with an abnormal dexamethasone suppression test (DST). Antidepressant therapy resulted in consistent reversal of the DST and partial remission of the patient's vegetative signs. Nevertheless, the patient's condition deteriorated over 36 months to end-stage dementia.
When insulin has to work hard to keep the sugar at bay the upper airway collapses away
Authors: Danny J. Eckert, Arie Oliven
Journal: European Respiratory Journal (2016)

Obesity is a major risk factor for both obstructive sleep apnoea (OSA) and metabolic disease. As obesity rates continue to rise, so too does the prevalence of OSA and metabolic disorders. Indeed, recent community sample data from over 2000 adults aged 40–85 years in Switzerland indicate that up to 50% of men and almost a quarter of women have apnoea–hypopnoea indices (AHI) within the moderate to severe range (>15 events·h−1 sleep) [1]. Insulin resistance, a strong predictor for the development of type 2 diabetes [2], is being recognised earlier with prevalence rates in children varying between 3 and 44% [3]. Thus, OSA and insulin resistance are major health issues. Insulin resistance may increase upper airway collapsibility and directly contribute to sleep apnoea pathogenesis <http://ow.ly/10BTf9>
Phospholipid End‐Capped Acid‐Degradable Polyurethane Micelles for Intracellular Delivery of Cancer Therapeutics
Authors: Johnson V. John, Reju George Thomas, Hye Ri Lee, Hongyu Chen, Yong Yeon Jeong, Il Kim
Journal: Advanced Healthcare Materials (2016)

Nanoscale drug carriers fabricated by phospholipid end-capped polyurethane bearing acetal backbones that degrade in acidic conditions are fabricated. These micelles effectively allow drugs to enter the blood circulation, and then disintegrate in acidic endosomes and lysosomes for intelligent delivery of payloads.
Doxorubicin/heparin composite nanoparticles for caspase-activated prodrug chemotherapy
Authors: Nisar Ul Khaliq, Febrina Carolina Sandra, Dal Yong Park, Jae Young Lee, Keun Sang Oh, Dongkyu Kim, Youngro Byun, In-San Kim, Ick Chan Kwon, Sang Yoon Kim, Soon Hong Yuk
Journal: Biomaterials (2016)
J. R. Elkinton and the Editorial Road
Authors: E.J. H.
Journal: Annals of Internal Medicine (1971)

Editorials1 July 1971J. R. Elkinton and the Editorial RoadE.J. H.E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-75-1-128 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the preceding editorial Dr. Marshall Fulton, Chairman of the Committee on Publications through most of Dr. Elkinton's editorship, has sketched many of his attributes and how they have influenced the content and style of the ANNALSthrough the past decade. From my view of Dr. Elkinton's editorship as his associate through all of his service, I venture to judge that he considered reliability of content to be among the leading desiderata for growth of the journal's reputation. His first major decision on assuming the editorship in 1960 was to seek and to continue to seek the critical advice of...Reference1. ELKINTONDANOWSKI JT: The Body Fluids: Basic Physiology and Practical Therapeutics. Baltimore, The Williams & Wilkins Co., 1955 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIn Memoriam: J. Russell Elkinton, MD, MACP, FRCP(L); 1910–2002; Editor, Annals of Internal Medicine, 1960–1971Edward J. Huth, MD, Editor EmeritusA Tribute to Edward Huth, EditorJohn R. Ball, MD, JDJ. Russell Elkinton, M.D., M.A.C.P.: A TributeMARSHALL N. FULTON, M.D. 1 July 1971Volume 75, Issue 1Page: 128-130 ePublished: 1 December 2008 Issue Published: 1 July 1971 PDF downloadLoading ...
PTH-134 Reduced calcineurin inhibitor exposure early after liver transplantation protects against renal dysfunction independently of the use of basiliximab induction therapy
Authors: S Onali, A Mansell, S Aspite, L De Luca, E Tsochatzis, J O’Beirne, D. Patch, D Thorburn, M Pinzani, P Manousou
Journal: Gut (2015)

<h3>Introduction</h3> Basiliximab use with delayed entry of Tacrolimus (TAC) as renal sparing agent may help reduce renal impairment in liver transplant (LT) recipients. We aimed to evaluate factors affecting renal dysfunction and the effect of basiliximab post-LT. <h3>Method</h3> All consecutive LT patients (1/2006–1/2014) with a follow up &gt;3months and eGFR &lt;90 ml/min/1.73m<sup>2</sup>at day 1 post-LT were analysed for factors known to affect renal dysfunction: biochemical/clinical data, donor age, cold/warm ischemia time, mean trough TAC levels up to days 7, 15, 30 post-LT, basiliximab use, initial/maintenance immunosuppression, acute cellular rejection (ACR), diabetes mellitus (DM) pre and post-LT, systemic hypertension, days on filtration post-LT. Renal impairment was defined as mild: eGFR 60–89 and moderate/severe: eGFR &lt;60. Endpoints were eGFR at 3 months and at last follow up post-LT. <h3>Results</h3> 126 patients given basiliximab were compared with 189 consecutive patients with eGFR &lt;90 at day 1 post-LT (control group). Basiliximab group had mean TAC trough levels 3.4ng/ml vs 5.9ng/ml of controls at the first week and 4.2ng/ml vs 6.6 ng/ml respectively at 15 days post-LT. 20(16%) on basiliximab had ACR vs 72/188(38%) controls (p = 0.001). Of those not on basiliximab, 35%(35/97) with TAC levels &gt;5 ng/ml vs 41%(38/92) with TAC &lt;5 ng/ml at week 1 post-LT experienced ACR episodes (p=NS). Logistic regression analysis showed that factors associated with moderate-severe renal impairment (eGFR &lt;60) at 3 months post-LT were: recipient age &gt;50years (p &lt; 0.001, OR=1.06, 95% CI=1.03–1.1), mean CNI levels &gt;5 ng/ml at week 1 post-LT(p = 0.003, OR=0.4, 95% CI=0.3–0.7) and mean CNI levels &gt;7 ng/ml up to 15 days post-LT(p = 0.019 OR=0.85, 95% CI=0.75–0.97). The same factors were associated with mild renal impairment (eGFR &lt;90). Factors associated with moderate/severe renal impairment at last follow up (median 48 m) in the Cox regression analysis were: mean TAC levels &gt;7 ng/ml at days 15 post-LT (p = 0.003 OR=1,9 95% CI=1.2–2.9) and use of steroids &gt;3months post-LT(p = 0.006, OR=0.7, 95% CI=0.5–0.9). <h3>Conclusion</h3> Basiliximab use allows reduced TAC trough levels with less episodes of ACR compared with the control group. However, TAC trough levels &lt;7 ng/ml at 15 days post-LT regardless of basiliximab use, were protective of renal function without predisposing to ACR in patients with renal impairment at baseline. <h3>Disclosure of interest</h3> None Declared.
Sources of Variation in Sweat Chloride Measurements in Cystic Fibrosis
Authors: Joseph M. Collaco, Scott M. Blackman, Karen S. Raraigh, Harriet Corvol, Johanna M. Rommens, Rhonda G. Pace, Pierre-Yves Boelle, John McGready, Patrick R. Sosnay, Lisa J. Strug, Michael R. Knowles, Garry R. Cutting
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Expanding the use of cystic fibrosis transmembrane conductance regulator (CFTR) potentiators and correctors for the treatment of cystic fibrosis (CF) requires precise and accurate biomarkers. Sweat chloride concentration provides an in vivo assessment of CFTR function, but it is unknown the degree to which CFTR mutations account for sweat chloride variation.