tbuckley/cabot-search huggingface dataset:
Abstract B08: Inflammasome components caspase-1, IL1β, IL18 and NLRP3 (NOD-like receptor family, pyrin domain containing 3) are increased in a spontaneous model (chicken: Gallus gallus) of human ovarian cancer
Authors: Judith Luborsky, Seara Edassery, Seby L. Edassery, Animesh Barua, Janice M. Bahr
Journal: Cancer Research (2016)

Abstract Chronic inflammation is associated with cancer risk and development. There is increasing evidence that a chronic, pro-inflammatory environment is mediated by multi-protein inflammasome complexes that promote activation of IL1β and IL18, which are apex cytokines for regulation of inflammation. The objective was to determine if the inflammasome components NLRP3, caspase-1, IL1β and IL18 were expressed in ovarian cancer and if the expression differed between normal ovary and ovarian tumors using the hen, an animal model of spontaneous ovarian cancer. mRNA was measured by qRT-PCR using primers based on chicken orthologs of human genes from the NCBI database as follows, NLRP3 XM_001233261.3; Caspase-1 XM_003642384.2; IL1β NM_204524.1; IL18 NM_204608; IL17 NM_204460.1. mRNA expression (mean fold change compared to normal ovary = mFC) was increased significantly (t -test) compared to normal ovaries for caspase-1 (mFC=14.6±12.6; p=0.01), IL1β (mFC=6.5±5.3 p=0.01) and IL18 (mean fold change=4.9±3.4; p=0.01) with a moderate increase in NLRP3 (mFC=1.7±0.98; p=0.04) in cancer (n=8) compared to normal ovary (n=6). Expression of the pro-inflammatory cytokine, IL17 was increased (mFC=4.0±6.0; p=0.1) but not significantly in this limited sample set. Moderate protein expression of the same components was evident by immunohistochemistry in groups of tumor cells but not in all tumor cells. Expression also occurred in tumor immune cells; the number of immunohistochemically reactive immune cells varied among tumors. Differences in invading immune cells with an activated inflammasome could account for the range of total mRNA values; differences among tumor expression of inflammasomes infers a potential basis for differences in response to immunotherapies. The results demonstrate expression of inflammasome components in a spontaneous model resembling human ovarian cancer and suggest a mechanism by which a chronic pro-inflammatory, pro-tumor environment is maintained. Improved understanding of the role of inflammasomes could lead to methods for management of the tumor immune environment and responses to immunotherapy. Citation Format: Judith Luborsky, Seara Edassery, Seby L. Edassery, Animesh Barua, Janice M. Bahr. Inflammasome components caspase-1, IL1β, IL18 and NLRP3 (NOD-like receptor family, pyrin domain containing 3) are increased in a spontaneous model (chicken: Gallus gallus) of human ovarian cancer. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr B08.
Case 21-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, James E. Dalen, Eugene J. Mark
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 76-year-old woman was admitted to the hospital because of dyspnea and abdominal pain.There was a long history of hypertension and a heart murmur, and she had experienced occasional chest pain on exertion, with questionable response to nitroglycerin. Seven years before entry syncope developed, and she came to this hospital. Physical examination showed evidence of aortic stenosis. Right-sided and left-sided cardiac catheterization showed that the right atrial mean pressure was 4 mm Hg, the right ventricular pressure 32/6 mm Hg, the pulmonary-artery pressure 32/12 mm Hg, the pulmonary arterial mean pressure 20 mm Hg, the pulmonary-capillary . . .
The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder [published erratum appears in Am J Psychiatry 1993 Aug;150(8):1280]
Authors: M F Ward, P H Wender, F W Reimherr
Journal: American Journal of Psychiatry (1993)

In an attempt to surmount the problem of retrospectively establishing the childhood diagnosis of attention deficit hyperactivity disorder, the authors constructed the 61-item Wender Utah Rating Scale (WURS) for adults to use to describe their own childhood behavior. In this paper they present their initial data collection and evaluation of the instrument's validity.The scale was administered to 81 adult outpatients with attention deficit hyperactivity disorder, 100 "normal" adults, and 70 psychiatric adult outpatients with unipolar depression. The authors analyzed data from the 25 items of the scale that showed the greatest difference between the patients with attention deficit hyperactivity disorder and the normal comparison subjects and the relationship between the WURS and the patients' parents' judgment of childhood activity as measured by the Parents' Rating Scale.The patients with attention deficit hyperactivity disorder had significantly higher mean scores on all 25 items than did the two comparison groups. The difference between the mean total scores of the patients with attention deficit hyperactivity disorder and the normal subjects was also highly significant. A cutoff score of 46 or higher correctly identified 86% of the patients with attention deficit hyperactivity disorder, 99% of the normal subjects, and 81% of the depressed subjects. Correlations obtained between WURS scores and Parents' Rating Scale scores were moderate but impressive. The ability of WURS scores to predict response to methylphenidate replicated the authors' finding regarding the ability of Parents' Rating Scale scores to predict response to pemoline.The WURS is sensitive in identifying childhood attention deficit hyperactivity disorder and may be useful in recognizing attention deficit hyperactivity disorder in patients with ambiguous adult psychopathology.
The frequency of major psychiatric disorder in Chinese inpatients
Authors: S M Yan, D Z Xiang, Y Z Chao, D Y Chen, D Q Zhang, M A Taylor
Journal: American Journal of Psychiatry (1984)

The authors applied DSM-III criteria to 268 consecutive Chinese inpatients. Nearly a quarter had affective disorder, a third had schizophrenia, and, except for one patient, none had alcoholism or drug abuse. The authors discuss the factors influencing hospitalization in China.
Immunological Consequences of Intestinal Fungal Dysbiosis
Authors: Matthew L. Wheeler, Jose J. Limon, Agnieszka S. Bar, Christian A. Leal, Matthew Gargus, Jie Tang, Jordan Brown, Vincent A. Funari, Hanlin L. Wang, Timothy R. Crother, Moshe Arditi, David M. Underhill, Iliyan D. Iliev
Journal: Cell Host & Microbe (2016)
Abstract B14: Targeting a network of cancer control nodes through rescue of c-Cbl: A novel therapeutic approach in GBM
Authors: Jennifer L. Stripay, Brett M. Stevens, Addie L. Bardin, Mark D. Noble
Journal: Cancer Research (2015)

Abstract Glioblastoma multiforme is the most common primary brain tumor in adults, the most malignant of all intracranial tumors, and is associated with inevitable recurrence and 15 month mean survival despite multimodal therapy. The majority of GBM tumors maintain heterogeneous amplifications (many in the absence of genetic mutation) in receptor tyrosine kinases (RTKs), which are mediators of growth factor signaling. Our lab has discovered that control over RTK levels in normal CNS progenitors is maintained by the Redox/Fyn/c-Cbl (RFC) pathway whereby increased oxidative state results in activation of the E3 ubiquitin ligase c-Cbl and the subsequent internalization and degradation of target RTKs. RFC signaling is disrupted in GBM due to a physical sequestration of c-Cbl, preventing pro-oxidative chemotherapeutics from reducing pro-survival signaling through Epidermal Growth Factor Receptor, Platelet-Derived Growth Factor Receptor, etc. Using a triangulating drug screen, we identified candidate FDA-approved small molecules capable of reducing signaling downstream of c-Cbl-targeted RTKs. We found that candidate URMC-06, an antidepressant with a good clinical safety profile, could rescue RFC signaling and significantly enhance the sensitivity of GBM cells to a pro-oxidative agent (Tamoxifen) in a c-Cbl-dependent manner. There is significant evidence to suggest that a tumor initiating cell population mediates the malignancy of GBM tumors. These cells express stem-cell associated markers and exhibit self-renewal capacity. We observed a c-Cbl-dependent inhibition of neurosphere formation (an in vitro measure of self-renewal) and a reduction in the expression of stem cell markers Sox2, beta-catenin, FoxM1 and Nestin in GBM cells treated with URMC-06. Our candidate also facilitated reduction in heat shock signaling and an inhibition of autophagy (both putative survival mechanisms) in GBM cells. URMC-06 was effective, in combination with clinically relevant agents (Temozolomide and Tamoxifen), at reducing tumor progression in an in vivo xenograft model of GBM. Our work supports the hypothesis that c-Cbl is a critical player in GBM that integrates multiple nodes of cancer control and that pharmacological rescue of c-Cbl represents a potentially powerful therapeutic approach. Citation Format: Jennifer L. Stripay, Brett M. Stevens, Addie L. Bardin, Mark D. Noble. Targeting a network of cancer control nodes through rescue of c-Cbl: A novel therapeutic approach in GBM. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr B14.
Production of Malignancy &lt;italic&gt;in vitro&lt;/italic&gt;. XII. Further Transformations of Mouse Fibroblasts to Sarcomatous Cells
Authors: Katherine K. Sanford, Wilton R. Earle, Emma Shelton, Edward L. Schilling, Emily M. Duchesne, Gwendolyn D. Likely, Mary M. Becker
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article Production of Malignancy in vitro. XII. Further Transformations of Mouse Fibroblasts to Sarcomatous Cells Get access Katherine K. Sanford, Katherine K. Sanford Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle, Wilton R. Earle Search for other works by this author on: Oxford Academic PubMed Google Scholar Emma Shelton, Emma Shelton Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward L. Schilling, Edward L. Schilling Search for other works by this author on: Oxford Academic PubMed Google Scholar Emily M. Duchesne, Emily M. Duchesne Search for other works by this author on: Oxford Academic PubMed Google Scholar Gwendolyn D. Likely, Gwendolyn D. Likely Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary M. Becker Mary M. Becker National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 2, October 1950, Pages 351–375, https://doi.org/10.1093/jnci/11.2.351 Published: 01 October 1950 Article history Received: 25 July 1950 Published: 01 October 1950
Abstract P4-03-07: Contribution of high-resolution ultrasonography in the diagnosis of non-palpable breast cancer with calcification
Authors: T Arai, K Takebe
Journal: Cancer Research (2016)

Abstract Background: In diagnosis of non-palpable calcificated breast cancer (NPCBC), stereo-guided mammotome (ST-MMT) serves as the standard. However, ultrasound resolution has improved dramatically recently. We hypothesized that through ultrasonography, it will become possible to diagnose NPCBC by US guided examination such as fine needle aspiration cytology (FNAC) and core needle biopsy (CNB) with much less invasion than ST-MMT. Method: (Study1) The results of ultrasonic detection ability and US guided examination were studied among the benign lesions of 35 cases and 90 NPCBC patients histologically diagnosed in our facilities from 2010 to 2012. Of the 90 histological types, 74 (82%) were DCIS, and 16 (18%) were invasive carcinoma. (Study 2) The results of 193 progress observation cases from 2008 to 2012 with Birads Category 3 and 4a calcification were examined. Result: (Study1) Using ultrasonography (Toshiba Aprio XG), calcification was detected in 88 of the 90 NPCBC lesions as echogenic foci. Two non-detectable lesions were DCIS of Van Nuys 1 and Van Nuys 2. The results of the FNAC were 80% positive and 20% indeterminate (there were no negative cases). In the 88 cases of possible calcified substance extracted through FNAC, 99% were confirmed under microscopic observation. (Study 2) 163 of 193 cases were able to be followed-up every six months for two to four years. An increase in calcification was observed in nine cases. Five of these cases were diagnosed with DCIS: Four were Van Nuys 1; one was Van Nuys 2. All five cases were of low-grade-malignancy. Conclusion: The diagnostic method using FNAC to visualize calcification using high-resolution ultrasonography is an effective method to reduce the non-efficient, invasive breast cancer detecting method of ST-MMT. The diagnostic method is particularly useful in women of small breast size in Asian countries. The few low-grade DCIS cases included were not detected with ultrasound. However, we believe it is not a diagnostic error. As a result, we stopped using the ST-MMT from 2010. In spite of this, in the MMG screening performed in our facilities from 2010 to 2012, the detection rate of NPCBC without mass on MMG was 0.17 %. This detection rate is excellent in our country. Citation Format: Arai T, Takebe K. Contribution of high-resolution ultrasonography in the diagnosis of non-palpable breast cancer with calcification. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-03-07.
New endemic West Nile virus lineage 1a in northern Italy, July 2012
Authors: L Barzon, M Pacenti, E Franchin, E Lavezzo, T Martello, L Squarzon, S Toppo, F Fiorin, G Marchiori, F Russo, M Cattai, R Cusinato, G Palù
Journal: Eurosurveillance (2012)

Binary file ES_Abstracts_Final_ECDC.txt matches
A measles outbreak in children under 15 months of age in La Rioja, Spain, 2005-2006
Authors: M Perucha, E Ramalle-Gómara, M E Lezaun, A Blanco, C Quiñones, M Blasco, M A Gonzalez, C Cuesta, J E Echevarria, M M Mosquera, F de Ory
Journal: Eurosurveillance (2006)

This paper describes a measles outbreak in La Rioja, Spain, which began in December 2005 and mainly affected children under 15 months of age who were not yet immunised with MMR vaccine. The measles cases were detected by the mandatory reporting system, under which laboratories must report every confirmed measles case. Cases were classified in accordance with the National Measles Elimination Plan: suspected and laboratory-confirmed. In the period 14 December 2005 to 19 February 2006, 29 suspected cases of measles were investigated, and 18 were confirmed. The mean incubation period was 13.8 days (range: 9 to 18). Of the 18 confirmed cases, only two were in adults. MMR vaccination was recommended for all household contacts, as well as for children aged 6 to 14 months who attended the daycare centres where the cases had appeared. At these centres, the second dose of MMR was administered ahead of schedule for children under three years of age. It was recommended that the first dose of MMR vaccine be administered ahead of schedule for all children aged 9 to 14 months. During an outbreak of measles, children aged 6 months or older, who have not previously been vaccinated against measles, mumps and rubella, should receive a first dose as soon as possible, and those who have had a first dose should receive a second dose as soon as possible, provided that a minimum of one month has elapsed between the two doses.
A Wash-Free Homogeneous Colorimetric Immunoassay Method
Authors: Huiqiao Liu, Pengfei Rong, Hongwei Jia, Jie Yang, Bo Dong, Qiong Dong, Cejun Yang, Pengzhi Hu, Wei Wang, Haitao Liu, Dingbin Liu
Journal: Theranostics (2015)

Rapid and convenient biosensing platforms could be beneficial to timely diagnosis and treatment of diseases in virtually any care settings. Sandwich immunoassays, the most commonly used methods for protein detection, often rely on expensive tags such as enzyme and tedious wash and incubation procedures operated by skilled labor. In this report, we revolutionized traditional sandwich immunoassays by providing a wash-free homogeneous colorimetric immunoassay method without requirement of any separation steps. The proposed strategy was realized by controlling the growth of gold nanoparticles (AuNPs) to mediate the interparticle spacing in the protein-AuNP oligomers. We have demonstrated the successful in vitro detection of cancer biomarker in serum samples from patients with high clinical sensitivity and specificity.
MYC Translocations Are Associated with Poor Overall Survival in DLBCL Patients in Both the Chemotherapy and Immunochemotherapy Eras.
Authors: Ahmet Dogan, Matthew J Maurer, William R Macon, David J Inwards, Ivana N Micallef, Patrick L Johnston, Mark Law, Kay Ristow, Thomas E Witzig, James R Cerhan, Thomas M Habermann
Journal: Blood (2009)
Abstract B27: Involvement of c-MET signaling in BCRP/ABCG2 activation and resistance to doxorubicin and photodynamic therapy
Authors: Bo-hyun Choi, Kyeong-Ah Jung, Mi-Kyoung Kwak
Journal: Cancer Research (2016)

Abstract Overexpression of BCRP/ABCG2, a xenobiotic efflux transporter, is related to anticancer drug resistance in tumors. Proto-oncogene c-MET induces cancer cell proliferation, motility, and survival, and its aberrant activation was found to be a prognostic factor in advanced ovarian cancers. In this study, we demonstrate the potential cross-resistance of doxorubicin-resistant ovarian cancer cells to the pheophorbide a (Pba)-based photodynamic therapy (PDT) and suggest c-MET and BCRP/ABCG2 overexpression as an underlying molecular mechanism. The doxorubicin resistant A2780 cell line (A2780DR) showed enhanced resistance to PDT cytotoxicity with decreased level of reactive oxygen species generation and Pba accumulation than A2780. In microarray analysis, BCRP/ABCG2 is the sole drug transporter which was upregulated in A2780DR. The incubation with the BCRP/ABCG2 specific inhibitor reversed the both Pba-PDT and doxorubicin resistance in A2780DR. Importantly, we identified that the expression of c-Met, which is an oncogene activating PI3K signaling, was increased in A2780DR and the inhibition of PI3K/AKT or c-MET repressed resistance to doxorubicin and PDT. Finally, we showed that the pharmacological and genetic inhibition of c-MET diminished levels of BCRP/ABCG2 in A2780DR. Collectively, our results provide evidence that c-MET overexpression is linked to BCRP/ABCG2 activation and this mechanism leads to crossresistance to both chemotherapy and PDT. Citation Format: Bo-hyun Choi, Kyeong-Ah Jung, Mi-Kyoung Kwak. Involvement of c-MET signaling in BCRP/ABCG2 activation and resistance to doxorubicin and photodynamic therapy. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr B27.
Initial findings on preventive intervention for families with parental affective disorders
Authors: W R Beardslee, L Hoke, I Wheelock, P C Rothberg, P van de Velde, S Swatling
Journal: American Journal of Psychiatry (1992)

The purpose of this study was to develop a clinician-based cognitive, psychoeducational, preventive intervention for families with parental affective disorder that would be suitable to widespread use, test its feasibility and safety, and define the areas affected by the intervention. The intervention was designed to increase understanding of parental illness and resilience in the children.The authors studied the first seven families (14 parents) to receive the intervention. Enrollment criteria included affective disorder during the preceding year in at least one parent, presence of at least one child between the ages of 8 and 14 years who was not psychiatrically ill at the time of participation, and willingness to participate in the research study. The intervention consisted of parent, child, and family sessions. Assessment included semistructured interviews with parents about affective disorders, standard ratings of marital satisfaction and therapeutic alliance, and a recently developed semistructured interview to assess response to the intervention.Overall satisfaction with the intervention was rated moderate to high by parents. No harm was reported. Ten of 14 parent subjects reported five or more behavior and attitude changes that they attributed to the intervention. The most frequent behavior and attitudinal changes reported were increased discussion of the illness and related issues and increased understanding of information about affective illness.The authors conclude that the intervention is safe and feasible in families with parental affective disorder.
Evidence for a graft-versus-tumor effect in a patient treated with marrow ablative chemotherapy and allogeneic bone marrow transplantation for breast cancer
Authors: B Eibl, H Schwaighofer, D Nachbaur, C Marth, A Gachter, R Knapp, G Bock, C Gassner, L Schiller, F Petersen, D Niederwieser
Journal: Blood (1996)
P-178 First-line chemotherapy with gemcitabine in advanced pancreatic cancer: a retrospective single-center analysis
Authors: H. Magalhães, M. Cassiano Neves, M. Fontes e Sousa, M. Machado, D. Marques, C. Faustino, N. Sousa, P. Ferreira, A. Raimundo, M. Fragoso, M. Luis, C. Sales
Journal: Annals of Oncology (2015)
Cardiovascular diseases in Paralympic athletes
Authors: Antonio Pelliccia, Filippo M Quattrini, Maria Rosaria Squeo, Stefano Caselli, Franco Culasso, Mark S Link, Antonio Spataro, Marco Bernardi
Journal: British Journal of Sports Medicine (2016)

Sport participation (SP) of individuals with impairments has recently grown exponentially. Scarce scientific data, however, exist regarding cardiovascular (CV) risk associated with competitive SP.Assessing the prevalence of CV abnormalities and the risk for SP in Paralympic athletes (PA).PA (n=267; 76% men), aged 35±9 years, engaged in 18 sport disciplines, with a spectrum of lesions including: spinal cord injury (paraplegia and spina bifida) (n=116); amputation, poliomyelitis, cerebral palsy and other neuromuscular and/or skeletal disorders (Les autres) or visual impairment (n=151) entered the study. CV evaluation included history, PE, 12-lead and exercise ECG, echocardiography. Of these, 105 participated in ≥2 consecutive games, and had evaluations available over a 6±4 year follow-up.Structural CV abnormalities were identified in 33 athletes (12%), including arrhythmogenic cardiomyopathies in 3, aortic root dilation in 3, valvular diseases in 7 (mitral valve prolapse in 4, bicuspid aortic valve in 3) and systemic hypertension in 11 (4%). In addition, ventricular (polymorphic, couplets or non-sustained ventricular tachycardia) or supraventricular tachyarrhythmias (atrial flutter, paroxysmal atrial fibrillation or SVT) were identified in 9 others. Over a 6-year follow-up, 6 of the 105 athletes (6%) developed CV diseases, including dilated cardiomyopathy in 1 and systemic hypertension in 5.PA present an unexpected high prevalence of CV abnormalities (12%), including a non-trivial proportion of diseases at risk for sudden death (2%), such as arrhythmogenic cardiomyopathies and dilated aortic root. This observation suggests that tailored recommendations for preparticipation screening and safe SP in this special athletic population are timely and appropriate.