tbuckley/cabot-search huggingface dataset:
AB0740 Comparative Study of Patients with Peripheral Psoriatic Arthritis, Axial Psoriatic Arthritis and Axial Spondyloarthritis without Psoriasis
Authors: A. Danve, N. Garg, A. Reddy, J. Ku, A. Deodhar
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Axial involvement in Psoriatic Arthritis (PsA) is reported to be between 40 -70%<sup>1</sup>. We aimed to compare the disease characteristics and quality of life (QoL) in patients with PsA with axial involvement (PsAax), PsA with only peripheral disease without axial involvement (PsApr), and axial spondyloarthritis patients without psoriasis (axSpA). <h3>Objectives</h3> To compare the disease characteristics and quality of life (QoL) in patients with PsAax, PsApr, and axSpA <h3>Methods</h3> Patients seen at Oregon Health &amp; Sciences University with new diagnosis of PsAax between 2007 and 2012 were identified by searching electronic medical records. Age and sex matched patients with PsApr (polyarticular arthritis) and axSpA without psoriasis were identified. Demographic and clinical data was collected retrospectively. Disease activity and QoL was measured using validated measures like RAPID 3 and BASDAI. Statistical significance was estimated using Mann-Whitney, Chi square and Fisher9s exact tests as applicable. <h3>Results</h3> Twenty eight patients with PsAax were compared to age and sex matched patients with PsApr (n=26) and axSpA without psoriasis (n=29) respectively. Mean age, disease duration, BMI, BASDAI and RAPID 3 scores were similar among three groups (see Table). Smokers were more prevalent in axSpA than PsAPr patients (p=0.05). PsAax patients had more peripheral arthritis compared to axSpA patients (p=0.01 for both). Uveitis was significantly more prevalent in axSpA than the other 2 groups. Prevalence of depression was more in patients with psoriasis (PsAax and PsApr (about 40%)) compared to axSpA (24%) but did not reach statistical significance. Prevalence of fibromyalgia, inflammatory bowel disease, mean ESR and CRP were similar in all three groups. More patients in axSpA group used NSAIDs compared to PsAax group (p=0.05). DMARDs were used more often in patients with PsAax (p=0.01) and PsApr (p=0.01) than in axSpA. TNF blockers were used more often in PsAax than in axSpA group (p=0.03). <h3>Conclusions</h3> In this comparative study between PsA patients with axial and peripheral disease and axSpA patients without psoriasis, PsAax patients had higher prevalence of peripheral arthritis compared to those with axSpA alone. Uveitis was less prevalent in PsAax and PsApr compared to axSpA patients. Depression was more prevalent in patients with psoriasis suggesting an important impact on QoL related to skin disease. <h3>References</h3> Hanly JG, Russell ML, Gladman DD (1988) Psoriatic spondyloarthropathy: a long term prospective study. Ann Rheum Dis 47:386–393 <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1322
Abstract 300: CTGF is overexpression in asbestos-induced malignant mesothelioma and promotes beta-catenin-T-cell factor/Lef signaling.
Authors: Li Jiang
Journal: Cancer Research (2013)

Abstract It is a well-known fact that malignant mesothelioma is primarily caused by the exposure to asbestos. Due to the widespread use of asbestos, cases of malignant mesothelioma are increasing at a dramatic rate. Histopathological examinations have revealed different subtypes of malignant mesothelioma. Based on cellular morphology, it is classified into epithelial (EM), sarcomatous (SM) and biphasic (BM) (containing a mixture of epithelial and sarcomatous cells) subtypes. Although sarcomatous mesothelioma is not as common as epithelial mesothelioma, it is recognized as the most aggressive type of malignant mesothelioma and patients diagnosed with this type of mesothelioma usually have a remarkably short survival period. Driven by the interest to know what are the molecular mechanisms underlying the relatively more aggressive phenotype of sarcomatous mesothelioma, we have initiated our study. From the microarray results, we have singled out a candidate gene (connective tissue growth factor, CTGF) whose expression is significantly increased in SM samples compared to the EM and normal control. We found CTGF regulated mesothelioma cells, especial SM cells proliferation, migration, invasion via activating β-catenin-T-cell factor/Lef signaling pathway. Mesothelioma cells decreased proliferation, migration, invasion after knockdown CTGF. We injected mesothelioma cells or CTGF-knockdown mesothelioma cells into nude mice. The tumor size of CTGF-knockdown mesothelioma injection is significant smaller than non-treated mesothelioma, especially in SM. We also found a causal association between high CTGF expression and the poor prognosis of sarcomatous mesothelioma and that the underlying molecular mechanism is related to the promotion of EMT (epithelial-mesenchymal transition) by CTGF. Many EMT regulators including Slug, Snail and Twist have been activated when over-expressed CTGF in EM. Conversely, the MET also is found when knockdown CTGF in SM. Our study is expected to have a great impact by offering novel therapeutic targets which are urgently needed at present. Our preliminary data appears to be very promising and we are highly confident that through the manipulation of our candidate gene, we will be able to at least greatly reduce the malignancy of sarcomatous subtype of mesothelioma and extend patient's lifespan, if not fully cure it. Citation Format: Li Jiang. CTGF is overexpression in asbestos-induced malignant mesothelioma and promotes beta-catenin-T-cell factor/Lef signaling. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 300. doi:10.1158/1538-7445.AM2013-300
Abstract 1154: Genetic variation in NFκB signaling pathway genes in colorectal cancer susceptibility and survival
Authors: Jonas Ungerbäck, Dimitri Belenki, Mats Fredrikson, Nils Elander, Deepti Verma, Peter Söderkvist
Journal: Cancer Research (2012)

Abstract PURPOSE: Genetic alterations in inflammatory genes are associated with chronic inflammatory bowel disease, a well-known risk factor for colorectal cancer (CRC). The purpose of this study was to investigate the association between alterations in inflammatory NFκB signaling pathway genes and CRC susceptibility and survival. EXPERIMENTAL DESIGN: Using 344 CRC cases and 793 randomly selected healthy individuals from southeastern Sweden, we examined seven polymorphisms in NFκB, TNFAIP3, NLRP3, CARD8 and TLR4 genes. Chi-square tests and multiple logistic regression analysis were used to test for associations between the SNPs and CRC susceptibility, while log-rank tests and Cox proportional hazard regression were used to examine the association between the SNPs and CRC-specific survival. Loss of heterozygosity and mutational analyses of TNFAIP3 were carried out in 137 and 79 tumors, respectively. RESULTS: Adjusted for age, gender and polypoid/ulcerative CRC phenotype, a panel of heterozygous and mutant TNFAIP3 (rs6920220), mutant NF B −94 ATTG ins/del and heterozygous NLRP3 (Q705K) was associated with poorer survival in patients diagnosed with invasive CRC (aHR = 5.2 95% CI 2.5-10.9, P &amp;lt; 0.001). Continuous or partial LOH of 6q23.3, the location of the TNFAIP3 gene was detected in 17% of the colorectal tumors while mutations in TNFAIP3 were detected in two out of 79 colorectal tumors (2.5%). CONCLUSIONS: We propose TNFAIP3 as a novel tumor suppressor in CRC and also present evidence that a panel of the TNFAIP3 (rs6920220), NF B −94 ATTG ins/del and NLRP3 (Q705K) polymorphisms could be used as a prognostic marker to identify patients at high risk for rapid CRC progression and poor survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1154. doi:1538-7445.AM2012-1154
Assisted Reproductive Technologies: Analysis and Recommendations for Public Policy
Authors: K. Dawson
Journal: BMJ (1998)

New York State Task Force on Life and the Law, $12, pp 474

ISBN 1 881268 03 9

This report is a well referenced synthesis of many perspectives, which presents the views of some religions, doctors, infertile patients, and the courts, within the context of applications of assisted reproductive technology. It deals with the complex issues of gamete donation, the parental rights and responsibilities of patients and gamete donors, the recording of information relating to births arising from assisted reproductive technology, and also the issues raised by health insurance and money-back payment treatment plans that are unique to the United States.

Many well reasoned recommendations about the public policy implications of assisted reproductive technology are explained in the report, which will be useful …
SAT0588 Educational Quality of Knee Arthrocentesis Videos on Youtube
Authors: J. Fischer, J. Geurts, V. Valderrabano, T. Hügle
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Knee arthrocentesis is a commonly performed diagnostic and therapeutic procedure in rheumatology and orthopedic surgery. Classic teaching of arthrocentesis skills relies on hands-on practice under supervision. Video-based online teaching is an increasingly utilized educational tool in higher and clinical education. YouTube is a popular video-sharing Web site that can be accessed as a teaching source. <h3>Objectives</h3> The objective of this study was to assess the educational value of YouTube videos on knee arthrocentesis posted by health professionals and institutions during the period from 2008 to 2012. <h3>Methods</h3> The YouTube video database was systematically searched using 5 search terms related to knee arthrocentesis. Two independent clinical reviewers assessed videos for procedural technique and educational value using a 5-point global score, ranging from 1 = poor quality to 5 = excellent educational quality. As validated international guidelines are lacking, we used the guidelines of the Swiss Society of Rheumatology as criterion standard for the procedure. <h3>Results</h3> Of more than thousand findings, 13 videos met the inclusion criteria. Of those, 2 contained additional animated video material: one was purely animated, and one was a check list. The average length was 3.31±2.28 minutes. The most popular video had 1388 hits per month. Our mean global score for educational value was 3.1±1.0. Eight videos (62%) were considered useful for teaching purposes. Use of a “no-touch” procedure, meaning that once disinfected the skin remains untouched before needle penetration, was present in all videos. Six videos (46%) demonstrated full sterile conditions. There was no clear preference of a medial (n=8) versus lateral (n=5) approach. <h3>Conclusions</h3> A discreet number of YouTube videos on knee arthrocentesis appeared to be suitable for application in a Web-based format for medical students, fellows, and residents. The low-average mean global score for overall educational value suggests an improvement of future video-based instructional materials on YouTube would be necessary before regular use for teaching could be recommended. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1786
Interweaving Knowledge Resources to Address Complex Environmental Health Challenges
Authors: Beth Ellen Anderson, Marisa F. Naujokas, William A. Suk
Journal: Environmental Health Perspectives (2015)

Complex problems do not respect academic disciplinary boundaries. Environmental health research is complex and often moves beyond these boundaries, integrating diverse knowledge resources to solve such challenges. Here we describe an evolving paradigm for interweaving approaches that integrates widely diverse resources outside of traditional academic environments in full partnerships of mutual respect and understanding. We demonstrate that scientists, social scientists, and engineers can work with government agencies, industry, and communities to interweave their expertise into metaphorical knowledge fabrics to share understanding, resources, and enthusiasm.Our goal is to acknowledge and validate how interweaving research approaches can contribute to research-driven, solution-oriented problem solving in environmental health, and to inspire more members of the environmental health community to consider this approach.The National Institutes of Health's National Institute of Environmental Health Sciences Superfund Research Program (SRP), as mandated by Congress, has evolved to become a program that reaches across a wide range of knowledge resources. SRP fosters interweaving multiple knowledge resources to develop innovative multidirectional partnerships for research and training. Here we describe examples of how motivation, ideas, knowledge, and expertise from different people, institutions, and agencies can integrate to tackle challenges that can be as complex as the resources they bring to bear on it.By providing structure for interweaving science with its stakeholders, we are better able to leverage resources, increase potential for innovation, and proactively ensure a more fully developed spectrum of beneficial outcomes of research investments.Anderson BE, Naujokas MF, Suk WA. 2015. Interweaving knowledge resources to address complex environmental health challenges. Environ Health Perspect 123:1095-1099; http://dx.doi.org/10.1289/ehp.1409525.
AB0202 Changes and significance of dendritic cells in peripheral blood in patients with systemic lupus erythematosus
Authors: G. Wang, X. Zhao, D. Yu, X. Li, X. Li
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by immunological intolerance, hyperactivity of various immunocyte and production of a variety of autoantibodies. Although etiology of the disease remains unclear, there is an increasing evidence that the presence and accumulation of dendritic cells in target tissues may play a role in the pathogenesis of SLE. <h3>Objectives</h3> To explore the changes and significance of plasmacytoid dendritic cells (PDC), myeloid dendritic cells (MDC) and cytokines in peripheral blood in patients with SLE. <h3>Methods</h3> The propotions of PDC and MDC in peripheral blood from 38 SLE and 15 normal individuals were measured by flowcytometer. The concentrations of IFN-α, TNF-α and IL- 6 were detected using ELISA. <h3>Results</h3> 1. The levels of PDC and MDC in peripheral blood of SLE patients decreased significantly comparing with normal controls (P&lt;0.01). 2. It was found that the percentage of PDC in SLE patients with stable disease was significantly higher than patient with active disease (P&lt;0.05). No significant difference was found in MDC between patients with and without disease activity. 3. SLE patients with proteinuria had lower percentage of PDC comparing with patients without proteinuria (P&lt;0.05). In addition, anti-dsDNA negative patients had higher percentage of PDC than anti-dsDNA positive patients (P&lt;0.05). 4. The percentage of PDC was correlated significantly with SLEDAI, C3 and ESR (with r value of -0.363, 0.451, -0.453 and p value of 0.031, 0.001, 0.008 respectively). 5. Further study found SLE patients had higher level of IFN-α, IL-6 and TNF-α than controls (P&lt;0.05). No correlation was found between the percentage of PDC, MDC and level of IFN-α, IL-6 and TNF-α. <h3>Conclusions</h3> The percentages of PDC and MDC in peripheral blood are decreased in patients with SLE. The reduction of PDC is correlated with disease activity and kidney damage of SLE. <h3>Disclosure of Interest</h3> None Declared
Abstract 867: Oral contraceptive, menopausal hormone therapy use and risk of B-cell non-Hodgkin lymphoma in the California Teachers Study
Authors: Yani Lu, Jane Sullivan-Halley, Katherine D. Henderson, Huiyan Ma, Lei Duan, Sophia S. Wang, James Lacey, Ellen T. Chang, Dennis Deapen, Leslie Bernstein
Journal: Cancer Research (2010)

Abstract Objective: To evaluate whether use of oral contraceptives (OC) or menopausal hormonal therapy (MHT) is associated with B-cell non-Hodgkin lymphoma (NHL). Methods: Within the prospective California Teachers Study cohort, women under age 85 with no history of hematopoietic cancer were followed from 1995 through 2007 for diagnosis of B-cell NHL. Overall, 547 women of 116,779 women eligible for analysis of OC use and 402 of 54,758 postmenopausal women eligible for analysis of MHT use developed B-cell NHL. Relative risks (RR) and 95% confidence intervals (CI) were estimated by fitting multivariable Cox proportional hazards models. Results: Women who used OCs had marginally lower risk of B-cell NHL than women who had never used OCs (RR=0.86, 95% CI=0.69-1.06). The reduced risk was most pronounced among women who started OCs before age 25, but did not decrease with increasing duration. No association with MHT was observed when MHT ever users were compared to the never users (RR=1.05, 95% CI=0.83-1.33); this result was consistent across formulations of MHT [unopposed estrogen therapy (ET), combined estrogen and progestin therapy (EPT)]. Among women who had never used MHT, women with a bilateral oophorectomy had three times greater risk than those with natural menopause (RR=3.15, 95% CI=1.62-6.13), whereas there was no association with bilateral oophorectomy among women who had used MHT. In stratified analyses according to hysterectomy and oophrectomy status, ET and EPT did not affect risk for women with natural menopause or those with hysterectomy who had at least part of an ovary remaining. Among women who had a bilateral oophorectomy, ET reduced risk of NHL (RR=0.41, 95% CI=0.21-0.82). Conclusion: These data suggest that ET use decreases the risk of B-cell NHL among women with both ovaries removed, but not among women retaining at least part of an ovary. In other subgroups MHT does not influence risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 867.
SP0053 Human T Cells Recognize CD1A Antigen Presenting Molecules Bound to Lipid Autoantigens
Authors: D.B. Moody
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> For decades, human alpha beta T cells were thought to solely or predominantly recognize peptide antigens bound to MHC proteins. However CD1 proteins bind diverse lipid antigens and display them to T cells. These recent studies provide a new perspective on T cell function that expands the range of natural antigens for T cells to include many types of cellular lipids. CD1 proteins are expressed on key antigen presenting cells including B cells, myeloid dendritic cells and Langerhans cells. Many studies now show that CD1 proteins bind and display bacterial antigens for T cell recognition. However, information on lipid autoantigens has been very limited. Using new strategies by which autoantigens are extracted from human tissues and then added back to CD1a proteins, we report that lipid autoantigens for CD1a are hydrophobic oils including squalene, wax esters and free fatty acids. In human patients, CD1a autoreactive T cells are common in the blood and home to skin, joints and other tissues. Certain CD1a autoreactive T cells produce high levels of interleukin-22, a specialized cytokine implicated in inflammation and wound repair, whose production is associated with rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) activity. Whereas clinicians have long understood that oils and lipids have unexplained immunological properties, these studies provide a specific cellular mechanism of T cell response to lipids. Further, these studies of human polyclonal T cells suggest a new mechanism by which tissue damage releases lipid autoantigens and promote cytokine-driven inflammation in the joints and skin. Because all human express nearly identical CD1a proteins, these lipids can be developed as T cell immunomodulatory agents for use in all patients, regardless of the MHC background. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6256
PATHOLOGY OF EDWARDS SAPIEN TRANSCATHETER AORTIC VALVE FOLLOWING IMPLANTATION IN HUMANS
Authors: Kazuyuki Yahagi, Elena Ladich, Roya Zarpak, Oscar D. Sanchez, Tobias Koppara, Hiroyoshi Mori, Michelle Olson, Frank Kolodgie, Martin Leon, Michael Joner, Renu Virmani
Journal: Journal of the American College of Cardiology (2015)
Novel diagnostic approach to pancreatic cysts: is confocal laser endomicroscopy bridging the gap?
Authors: Marco Bruno
Journal: Endoscopy (2014)

With the advent and growing use of cross-sectional imaging, an increasing number of individuals are being diagnosed with a cyst in the pancreas. In the majority of cases, scanning is done for reasons other than the suspicion of pancreatic disease, and the finding of a pancreatic cyst is therefore coincidental. The reported prevalence rates vary, but even the most conservative estimates indicate that a sizable number of individuals are affected, all of whom are potential candidates for diagnostic and/or follow-up investigations [1].
Health bill risks disrupting care for offenders leaving prison, warns peer
Authors: M. Limb
Journal: BMJ (2011)

A Labour peer who led an independent review of prison drugs treatment has warned that the coalition government’s commissioning reforms could harm the healthcare of offenders.

Lord Patel of Bradford said integrated care was crucial for prisoners leaving custody with complex needs, including drug, alcohol, and mental health problems.

But, he told a seminar in London on 13 September: “I’m becoming more concerned that the continuity of care for people on release will be fragmented.”

Lord Patel chairs the prison drug treatment strategy review group. He was speaking at a seminar organised by the Westminster legal policy forum entitled “Next steps for offender health—assessing a renewed strategy.”

Under government reforms in England, it is proposed the NHS Commissioning Board will be responsible for coordinating the commissioning of all healthcare services …