tbuckley/cabot-search huggingface dataset:
FRI0404 Which factors are associated with X-rays lesions in early axial spondyloarthritis? Results from the desir cohort
Authors: M. Blachier, F. Canoui-Poitrine, C. Poulain, M. Dougados, S. Ferkal, B. Fautrel, P. Le Corvoisier, A. Rahmouni, V. Farrenq, S. Bastugi-Garin, P. Claudepierre
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> According to the recent ASAS criteria for spondyloarthritis (SpA), axial SpA can be diagnosed without any sacroiliac joints (SIJs) or spinal x-rays lesions. Furthermore, some studies suggested that those non radiographic axial SpA (nRaSpA) did not differ from the radiographic ones with respect to the main characteristics of SpA spectrum. The objective was to assess factors associated with early axial x-rays lesions within early axial SpA patients included in the DESIR cohort. <h3>Methods</h3> We conducted a cross-sectional study of baseline data inpatients from the DESIR cohort (with inflammatory back pain of less than 3 years)who fulfilled the ASAS criteria for aSpA. Demographic, clinical phenotype and activity, biological, quality of life data as well as radiographs and MRI scans of the SIJs and of the spine were collected at baseline. Patients were considered as having x-rays lesions if they had at least one grade 2 SIJ lesion or a grade of 2 on at least one vertebral edge or a grade of 1 on at least 2 vertebral edges (at the cervical or lumbar level according to mSASSS scoring). Associations between baseline characteristics and presence of x-rays lesions were evaluated by estimating multi-adjusted odd ratios (aORs) and their 95% confidence intervals (CIs) using a logistic regression model. <h3>Results</h3> 475 patients fulfilled the axial ASAS criteria and were included in the analysis. Their mean age was 33 (±8.6) years, 239 (50.3%) were men, and 395 (83.3%),HLA B27 positive. One hundred and eighty (37.9%) patients had x-rays lesions. In multivariate analysis, drinking (aOR=2.20 95% CI: 1.19-4.09; p=0.01), CRP level (aOR <sub>1sdincrease</sub>=1.43 95% CI: 1.10-1.85; p=0.007), NSAIDs mean daily intake (aOR<sub>1sdincrease</sub>=1.38 95% CI: 1.07-1.79; p=0.01), spine MRI inflammatory lesions and SIJ MRI inflammatory lesions (aOR=1.92 95% CI: 1.12-3.29; p=0.02 and aOR=2.39 95% CI: 1.46-3.89; p=0.0001 respectively) were positively associated with x-rays lesions. Conversely, good responder to NSAIDs (aOR=0.28 95% CI: 0.14-0.54; p=0.0001) and BAS-G (aOR=0.90 95% CI: 0. 82-0.99; p=0.04) were inversely associated with x-rays lesions. <h3>Conclusions</h3> These cross sectional results suggest that alcohol consumption, NSAIDs mean daily intake and response to NSAIDs, biological and MRI inflammation are independently associated with early axial x-rays lesions in early axial SpA. <h3>Disclosure of Interest</h3> M. Blachier: None Declared, F. Canoui-Poitrine: None Declared, C. Poulain: None Declared, M. Dougados: None Declared, S. Ferkal: None Declared, B. Fautrel: None Declared, P. Le Corvoisier: None Declared, A. Rahmouni: None Declared, V. Farrenq: None Declared, S. Bastugi-Garin: None Declared, P. Claudepierre Grant/Research support from: Pfizer
Abstract 1976: Monocytic/macrophagic differentiation status of human promyelocytic leukemia cells dictates targeting efficacy of NF-kappaB downstream gene productes
Authors: Amélie Vézina, Borhane Annabi
Journal: Cancer Research (2012)

Abstract Disruption of the endothelial blood-brain barrier (BBB) facilitates the translocation of circulating microbes and immune cells. As a consequence, secondary cerebral infections and development of brain pathologies may occur. Enhanced transendothelial migration of HL-60-derived macrophages was recently demonstrated, but the intrinsic signalling mechanisms involved poorly documented. In this study, we investigated NF-kB signalling pathway targets associated with phorbol 12-myristate 13-acetate (PMA)-induced promyelocytic HL-60 differentiation into macrophages. Given that the inhibition of matrix metalloproteinase (MMP)-9 and of cyclooxygenase (COX)-2 limits BBB disruption, we also investigated the efficacy of the chemopreventive and dietary-derived epigallocatechin-3-gallate (EGCG) molecule on the NF-kB-mediated transcriptional regulation of a panel of 89 biomarkers including MMP-9 and COX-2. PMA-induced HL-60 cell differentiation and adhesion were reflected by IkB degradation, a signalling process that was reversible by EGCG. Using gene expression arrays, we identified moderately-to-highly expressed NF-kB gene targets associated with HL-60 differentiation process, among which EGCG was able to efficiently inhibit gene and protein MMP-9 and COX-2 expression. In contrast, EGCG was not only inefficient in reversing some PMA-induced NF-kB genes in terminally-differentiated macrophages but rather showed selective antagonism towards COX-2 expression while that of MMP-9 still remained high. Decreased expression of the 67 kDa Laminin Receptor in terminally-differentiated macrophages may contribute to such differential EGCG efficacy. Our results suggest that MMP-9-mediated BBB disruption may be prevented by EGCG only during procarcinogenic processes that trigger HL-60 macrophagic differentiation. Terminally-differentiated macrophage transendothelial migration associated to neuroinflammation may however not be pharmacologically affected by such a specific class of chemopreventive flavonoid. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1976. doi:1538-7445.AM2012-1976
Corneal Staining in Systemic Lupus Erythematosus
Authors: George Link Spaeth
Journal: New England Journal of Medicine (1967)

AMONG the various ocular abnormalities in patients with systemic lupus erythematosus corneal changes have rarely been mentioned.1 2 3 4 5 6 7 8 9 Together with other eye findings, however, they form an important part of the clinical picture of this disease.Materials and MethodsTwenty-four patients hospitalized at the National Institutes of Health were given thorough ocular examinations, including slit-lamp biomicroscopy, binocular indirect ophthalmoscopy with pupils dilated, tonography and perimetry. After instillation of a drop from a fluorescein-impregnated filter paper strip‡ moistened with physiologic saline solution, the cornea was inspected with the Haag–Streit biomicroscope (magnification twenty-five times with a cobalt-blue filter in front of the light . . .
Incidental Finding of Tc-99m MDP Bone Scintigraphy in a Case of X-Linked Spondyloepiphyseal Dysplasia Tarda
Authors: Fang Yang, Hai-Qing Xu, Chun-Lin Li, Ji-Gang Yang
Journal: Clinical Nuclear Medicine (2012)

A 26-year-old male presented with a history of backache and multijoint pain over the preceding 15 years. Bone scintigraphy demonstrated a short spine in addition to abnormally increased activity in multiple joints. The patient was eventually diagnosed to have X-linked spondyloepiphyseal dysplasia tarda.
Abstract 82: Expression of MUC17, a marker of pancreatic cancer, is under the control of epigenetic modifications
Authors: Sho Kitamoto, Norishige Yamada, Seiya Yokoyama, Izumi Houjou, Michiyo Higashi, Masamichi Goto, Surinder K. Batra, Suguru Yonezawa
Journal: Cancer Research (2011)

Abstract MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract. It has been reported that aberrant MUC17 expression is observed in pancreatic ductal adenocarcinomas (PDACs) and correlated with the malignancy potential. In the present study, we provided the first report of the MUC17 gene expression through epigenetic regulation such as promoter methylation, histone modification and microRNA (miRNA) expression. To investigate DNA methylation status in the 5’flanking region of MUC17, MassARRAY analysis was performed on 10 cell lines. This method permits the high-throughput identification of the methylation sites and their semi-quantitative measurement. Near the transcriptional start site (−179 to +52), a high level of CpG methylation was observed in MUC17-negative/low cells (e.g., Panc-1), whereas that of MUC17-positive cells (e.g., AsPC-1) was low. We also examined the relationship between DNA methylation and histone modification in MUC17 expression by ChIP assay, resulting the presence of dimethyl-H3-K9 in cells with no or low MUC17 was confirmed, whereas histone H3-K9 was more highly acetylated in MUC17-positive cells than in cells with no or low MUC17. These results suggest that the combination of DNA methylation and histone H3-K9 modification contribute to MUC17 expression. Futhermore, in the result of miRNA microarray analysis, we revealed that the five potential miRNAs are existed for the post-transcriptional regulation of MUC17. Our findings indicate that MUC17 is regulated tightly through epigenetic manners including DNA methylation, histone modification and miRNA regulation and also suggest the possible functional importance of MUC17 in both physiological and pathological conditions. Furthermore, for the clinical aspect, the DNA hypomethylation was also observed in patients with PDAC. This may be of importance for the diagnosis of carcinogenic risk and the prediction of outcomes for cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 82. doi:10.1158/1538-7445.AM2011-82
Treatment of Bacterial Endocarditis with Cephalothin
Authors: James J. Rahal, Burt R. Meyers, Louis Weinstein
Journal: New England Journal of Medicine (1968)

Ten patients with bacterial endocarditis were treated with cephalothin. Nine (Streptococcus viridans, four, microaerophilic streptococcus, two, anaerobic streptococcus, one, and Staphylococcus aureus, two) appeared cured when studied six months to four years after therapy ended. The tenth (Staph. albus) had negative blood cultures at the time of death. In seven, bacterial strains were available for testing, and growth was inhibited by a 30-μg cephalothin disk. In two other patients with enterococcal endocarditis, no serum bactericidal activity was demonstrated in vitro after administration of cephalothin in combination with streptomycin. Side effects of cephalothin included mild rashes, fever and superficial thrombophlebitis. An excessive blood level (51 μg per milliliter) developed in a patient who had a serum creatinine of 2.2 mg per 100 ml. In another, serum creatinine rose from 1.7 to 6.6 mg per 100 ml after 8 gm daily for 23 days. Cephalothin appears to be an excellent substitute for penicillin in treating bacterial endocarditis due to Staph. aureus or streptococcus other than enterococcus in patients for whom penicillin G is contraindicated.
PREVALENCE OF ISCHEMIA IN PATIENTS WITH A CHRONIC TOTAL OCCLUSION AND PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Authors: Wijnand Stuijfzand, Roel Driessen, Pieter Raijmakers, Mischa Rijnierse, Maurits Hollander, Adriaan Lammertsma, Albert van Rossum, Alexander Nap, Niels Van Royen, Paul Knaapen
Journal: Journal of the American College of Cardiology (2016)
Epidemiologic Features of Chronic Atrial Fibrillation
Authors: William B. Kannel, Robert D. Abbott, Daniel D. Savage, Patricia M. McNamara
Journal: New England Journal of Medicine (1982)

In the Framingham Study 2325 men and 2866 women 30 to 62 years old at entry were followed biennially over 22 years for the development of chronic atrial fibrillation in relation to antecedent cardiovascular disease and risk factors. During surveillance, atrial fibrillation developed in 49 men and 49 women. The incidence rose sharply with age but did not differ significantly between the sexes. Overall, there was a 2.0 per cent chance that the disorder would develop in two decades. Atrial fibrillation usually followed the development of overt cardiovascular disease. Only 18 men and 12 women (31 per cent) had chronic atrial fibrillation in the absence of cardiovascular disease. Cardiac failure and rheumatic heart disease were the most powerful predictive precursors, with relative risks in excess of sixfold. Hypertensive cardiovascular disease was the most common antecedent disease, largely because of its frequency in the general population. Among the risk factors for cardiovascular disease, diabetes and electrocardiographic evidence of left ventricular hypertrophy were related to the occurrence of atrial fibrillation. The development of chronic atrial fibrillation was associated with a doubling of overall mortality and of mortality from cardiovascular disease.
P732Interrelations of cholesterol high density lypoproteids with viscosity of blood and inflammatory activity on DAS-28-CRP scale at patients with rheumatoid arthritis
Authors: D Bublikov, A Andrienko, A Nemcev, K Goryacheva
Journal: Cardiovascular Research (2014)

Aim. To estimate interrelations of cholesterol high density lipoproteids (HDL) level with activity an inflammation and viscosity of blood (VB) at patients with rheumatoid arthritis (RA).

Materials and methods. Research included patients wiht RA (n=114). Middle age made 55,77±1,12 years. All patients were have a rheumatoid factor in blood, lasting RA more than one year, an activity index on DAS-28-CRP 4,25±0,54. At the time of inclusion patients had no clinical and laboratory data of the sharp inflammatory process connected with an infection. Activity of an inflammation determined by DAS-28-CRP scale. VB - on the capillary viscometer.

Results. Negative correlation communication of the average force (r=0,65) between the HDL level and activity of RA on DAS-28-CRP is found. VB had negative correlation communication of the average force (r=0,45) with the HDL level and positive (r=0,85) with level of inflammatory activity on DAS-28-CRP scale.

Conclusion. The received interrelations once again emphasize a role of a system inflammation in development of a dislipidemiya and their thin mutually interlacings that demands profound studying of these processes.
Setting the Price for Cancer Drug Development
Authors: K. Nagy
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Setting the Price for Cancer Drug Development Get access Kate Nagy Kate Nagy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 5, 3 March 1993, Pages 352–353, https://doi.org/10.1093/jnci/85.5.352 Published: 03 March 1993
Abstract LB-515: Guanine nucleotide exchange factor Dock7 expression is increased in human glioblastoma and mediates tumor cell invasion.
Authors: David W. Murray, Sebastien Didier, Amanda Chan, Vincent Paulino, Nhan Tran, Annette Byrne, Marc Symons
Journal: Cancer Research (2012)

Abstract Glioblastoma multiforme (GBM), the most common and deadly adult brain malignancy, is an incurable disease with an average life expectancy of 14 months following diagnosis. GBM morbidity is primarily due to its rapid growth, neovascularization and invasion throughout the brain. Recently, anti-VEGF therapies approved in this indication have paradoxically been shown to stimulate the invasive behavior of GBM. Members of the Rho family of small GTPases have been established as important mediators of GBM cell invasion. These proteins are activated by guanine nucleotide exchange factors (GEFs). In the current study, we sought to identify GEFs that are up-regulated in high-grade glioma and which may be of functional importance in human GBM. In this study we have shown that that Dock7, a GEF that can mediate signaling of Rac1 and Cdc42 Rho GTPases is up-regulated in human GBM tissue in comparison with normal brain. We have further demonstrated that Dock7 silencing by RNA-interference inhibits invasion of U87 and SNB19 GBM cells into ex vivo brain slices. Dock7 silencing inhibits Hepatocyte Growth Factor (HGF)-induced cell invasion in a 3D in vitro assay. HGF is known to strongly stimulate GBM cell invasiveness and both HGF and its receptor c-MET have been shown to be up-regulated in high- versus low-grade gliomas. Interestingly, we have also shown that Dock7 binds to c-MET in an HGF-dependent manner and that this interaction requires the GAB1 adaptor protein. Dock7 silencing reduced HGF-induced activation of Rac1 and consistent with this, we have shown that Dock7 silencing results in the inhibition of HGF-induced lamellipodia formation in GBM cells. Finally Dock7 was shown to be activated in an HGF-dependant manner, using Rac1-G15A pull-down assay. In summary, our data suggests a role for Dock7 in GBM cell invasion thus, Dock7 may present a potential therapeutic target in the management of invasive GBM, in particular in the adjuvant setting in combination with anti-VEGF therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-515. doi:1538-7445.AM2012-LB-515
An Epidemiologic Study of Lyme Disease in Southern Sweden
Authors: J Berglund, R Eitrem, K Ornstein, A Lindberg, A Ringér, H Elmrud, M Carlsson, A Runehagen, C Svanborg, R Norrby
Journal: New England Journal of Medicine (1995)

Background.Lyme disease is the most common vector-borne infection in some temperate regions of the Northern Hemisphere.However, for most areas of endemic disease reliable epidemiologic data are sparse.Methods.Over a one-year period, we conducted a prospective, population-based survey of cases of Lyme disease in southern Sweden.The diagnosis was made on the basis of the presence of erythema migrans at least 5 cm in diameter or characteristic clinical manifestations such as arthritis, neuroborreliosis, and carditis.Results.We identified 1471 patients with Lyme disease, for an overall annual incidence of 69 cases per 100,000 inhabitants.The incidence varied markedly according to geographic region, and there were several areas where disease was widely prevalent.The incidence varied according to age, with the highest rates among people 5 to 9 and 60 to 74 years of age, but not according to sex.The most frequent clinical manifestation was erythema migrans (seen in 77 percent of all cases), followed by neuroborreliosis (16 percent) and arthritis (7 percent).Carditis was rare.A preceding tick bite was reported by 79 percent of the patients.Bites in the head and neck region were more common among children than among adults and were associated with an increased risk of neuroborreliosis.Conclusions.Lyme disease is very common in southern Sweden, with a relatively high frequency of neurologic complications and arthritis.With the exception of the low incidence of carditis, the pattern of disease we found in Sweden was similar to that reported in the United States.
SAFETY AND EFFICACY OF RIVAROXABAN IN PATIENTS WITH CARDIAC IMPLANTABLE ELECTRONIC DEVICES: OBSERVATIONS FROM THE ROCKET AF TRIAL
Authors: George Leef, Anne Hellkamp, Manesh Patel, Richard Becker, Scott Berkowitz, Guenter Breithardt, Jonathan Halperin, Christopher Nessel, Daniel Singer, Keith Fox, Kenneth Mahaffey, Jonathan Piccini
Journal: Journal of the American College of Cardiology (2016)
THU0561 Hyaluronan Alone, Combined with Botulinus Toxin or Placebo Injection Therapy for Treatment of Chronic Noninsertional Achilles Tendinopathy
Authors: R. Petrella, M. Petrella, J. Decaria
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Tendinopathy is a failed healing response of the tendon. Despite an abundance of therapeutic options, very few randomized prospective, placebo-controlled trials have been carried out to assist physicians in choosing the best evidence-based management. Mechanisms that propose to promote collagen fiber cross-link formation within the tendon, thereby facilitating tendon remodeling would be optimal. Hyaluronan may be a treatment option for midportion Achilles tendinopathy. <h3>Objectives</h3> To compare the effectiveness of 2 peri-tendinous injection management strategies utilizing Hyaluronan in patients with mid-portion non-insertional Achilles tendinopathy. <h3>Methods</h3> Thirty-five patients with a chronic recalcitrant (&gt;6 months) noninsertional Achilles tendinopathy were enrolled in a randomized controlled study. All patients had also received unsuccessful management for &gt;3 months, including nonsteroidal anti-inflammatory drugs and physiotherapy. A computerized random-number generator was used to draw up an allocation schedule. Hyaluronan (2.8cc, 730-1300kDa) or normal saline (2.8cc) was injected peri-tendinously under ultrasound guidance at baseline and 7 days. Assessments were done at baseline, days 7, 14, 30 and 90. Primary outcome measure was the VISA-A (Victorian Institute of Sport Assessment - Achilles) score. Secondary outcomes included patient's pain VAS on weight bearing (0-100mm), patients' global assessment of Achilles injury (5 point categorical scale), patients' assessment of normal function/activity (5 point categorical scale), physician's global assessment of Achilles injury (5 point categorical scale), patients/physician satisfaction assessment (10 point categorical scale), time to return to pain-free and disability-free sport and adverse events as per WHO definition. <h3>Results</h3> All patients completed the study. Two patients in the placebo group experienced injection pain. There were no severe adverse events. The VISA-A score increased in the Hyaluronan group, from 53 to 81 points (P&lt;0.01) at 30 days and to 92 points at 90 days (P 0.01). No change was noted in the placebo group. There was less weight bearing pain, and higher rated patient and physician global ratings at 14, 30 and 90 days compared to to the placebo group (P&lt; 0.001). There was a faster return to sport in the Hyaluronan group compared to placebo at 90 days (P&lt;0.001). <h3>Conclusions</h3> Hyaluronan injection therapy is an effective treatment for chronic noninsertional Achilles tendinopathy. <h3>Disclosure of Interest</h3> None Declared