tbuckley/cabot-search huggingface dataset:
Distinct evolution and dynamics of epigenetic and genetic heterogeneity in acute myeloid leukemia
Authors: Sheng Li, Francine E Garrett-Bakelman, Stephen S Chung, Mathijs A Sanders, Todd Hricik, Franck Rapaport, Jay Patel, Richard Dillon, Priyanka Vijay, Anna L Brown, Alexander E Perl, Joy Cannon, Lars Bullinger, Selina Luger, Michael Becker, Ian D Lewis, Luen Bik To, Ruud Delwel, Bob Löwenberg, Hartmut Döhner, Konstanze Döhner, Monica L Guzman, Duane C Hassane, Gail J Roboz, David Grimwade, Peter J M Valk, Richard J D'Andrea, Martin Carroll, Christopher Y Park, Donna Neuberg, Ross Levine, Ari M Melnick, Christopher E Mason
Journal: Nature Medicine (2016)
Tumors of the Alimentary Tract Induced in Mice by Feeding Olive-Oil Emulsions Containing Carcinogenic Hydrocarbons&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Egon Lorenz, Harold L. Stewart
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Tumors of the Alimentary Tract Induced in Mice by Feeding Olive-Oil Emulsions Containing Carcinogenic Hydrocarbons Get access Egon Lorenz, Egon Lorenz National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Stewart Harold L. Stewart National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 227–238, https://doi.org/10.1093/jnci/7.4.227 Published: 01 February 1947 Article history Received: 13 January 1947 Published: 01 February 1947
Ultrasound and Physiology
Authors: L BERLIN, I WALDMAN
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A method for quantifying and comparing civil commitment processes
Authors: L R Faulkner, B H McFarland, J D Bloom, T O Stern
Journal: American Journal of Psychiatry (1986)

The authors present a three-step civil commitment model and formulas for calculating 1) the probability of release from the commitment process and 2) the relative importance of the three steps in determining outcome. Using data from Oregon's civil commitment process, they present five examples that demonstrate how their method might be used to study and monitor civil commitment processes within and between jurisdictions. The major public policy and research implications are discussed.
HG-55DEVELOPMENT OF IN VIVO MODELS OF DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) FROM STEREOTACTIC BIOPSIES PERFORMED AT DIAGNOSIS
Authors: Alexandre Plessier, Ludivine Le Dret, Laurence Fiette, Sébastien Mériaux, Kévin Beccaria, Pascale Varlet, Stéphanie Puget, Jacques Grill, Marie-Anne Debily, David Castel
Journal: Neuro-Oncology (2016)
Car-Bird [Carfilzomib, Clarithromycin(Biaxin(R)), Lenalidomide/(Revlimid(R)), Dexamethasone) For Newly-Diagnosed Multiple Myeloma
Authors: Tomer M Mark, John N. Allan, Geoffrey Marano, Adriana C Rossi, Roger N Pearse, Faiza Zafar, Linda Tegnestam, Karen Pekle, David Jayabalan, Morton Coleman, Scott A Ely, Ruben Niesvizky
Journal: Blood (2013)
Executive impairment among the functionally dependent: comparisons between schizophrenic and elderly subjects
Authors: D R Royall, R K Mahurin, J E True, B Anderson, I P Brock, L Freeburger, A Miller
Journal: American Journal of Psychiatry (1993)

Executive deficits have traditionally been associated with frontal lobe brain damage. They are relevant to a variety of disabling mental conditions, including schizophrenia and Alzheimer's disease. To measure these deficits, the authors developed the Executive Interview, a 25-item, 15-minute interview. It has been validated among elderly subjects across a wide range of functional impairment.Forty young, chronically ill schizophrenic residents of a state mental health facility and 104 elderly residents, representing three levels of care, of a comprehensive retirement community were tested with the Executive Interview and the Mini-Mental State.When age, gender, education, and number of prescribed medications were controlled, cognitive impairment on the Executive Interview and Mini-Mental State rose with level of care. The Executive Interview alone discriminated between subjects at each level of care, and it was more sensitive to cognitive impairment than the Mini-Mental State. Executive Interview scores correlated the strongest with level of care. Mini-Mental State scores, number of prescribed medications, and age also correlated significantly. Schizophrenic patients showed as much executive impairment on the Executive Interview as elderly subjects at the same level of care despite significant differences in age, sex, and neuroleptic use. Executive Interview and Mini-Mental State scores were highly correlated among the elderly but less so among the schizophrenic patients. Cross-group differences were also found in the pattern of failure on selected Executive Interview items despite similar total Executive Interview scores.Increasing executive dyscontrol is associated with the need for increasing levels of care and supervision. This finding is neither age nor disease specific. Cross-group differences on selected Executive Interview items suggest the existence of disease-specific patterns of failure. Their recognition could prove useful in the identification of anatomically or pathophysiologically distinct subgroups among patients with executive dyscontrol.
NS-17A PHASE 1 SAFETY AND IMAGING STUDY OF BLZ-100 IN PEDIATRIC BRAIN TUMORS
Authors: Amy Lee, Bonnie Cole, Sandra Poliachik, Jeffrey Ojemann, Sam Browd, Dennis Miller, Carolyn Gombotz, Stacey Hansen, Laura Ishak, J. Russell Geyer, Sarah Leary
Journal: Neuro-Oncology (2016)
SmiNet-2: Description of an internet-based surveillance system for communicable diseases in Sweden
Authors: P Rolfhamre, A Janson, M Arneborn, K Ekdahl
Journal: Eurosurveillance (2006)

Electronic systems for communicable diseases surveillance enhance quality by simplifying reporting, improving completeness, and increasing timeliness. In this article we outline the ideas and technologies behind SmiNet-2, a new comprehensive regional/national system for communicable disease surveillance in Sweden. The system allows for reporting from physicians (web form) and laboratories (direct from lab data system) over the internet. Using a unique personal identification number, SmiNet-2 automatically merges clinical and laboratory notifications to case records. Privileged users, at national and county level, work against a common central server containing all notifications and case records. In addition, SmiNet-2 has separate county servers with tools for outbreak investigations, contact tracing and case management. SmiNet-2 was first used in September 2004. Individual counties receive up to 90% of all notifications electronically. In its first year, SmiNet-2 received 54 980 clinical notifications and 32 765 laboratory notifications, which generated 58 891 case records. Since most clinicians in Sweden have easy access to the internet, a general web-based reporting has been feasible, and it is anticipated that within a few years all reporting to SmiNet-2 will be over the internet. In this context, some of the major advantages of SmiNet-2 when compared with other systems are timeliness in the dataflow (up to national level), the full integration of clinical and laboratory notifications, and the capability to handle more than 50 diseases with tailor-made notification forms within one single system.
Incorporation of Acetate-1-C&lt;sup&gt;14&lt;/sup&gt; Into Cholesterol by Human Intracranial Tumors &lt;italic&gt;In Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Daniel L. Azarnoff, George L. Curran, William P. Williamson
Journal: JNCI Journal of the National Cancer Institute (1958)

Normal adult human brain does not incorporate C14-labeled acetate into cholesterol in vitro. Under similar conditions, glioblastoma multiforme, astrocytomas, meningiomas, neurofibromas, acoustic neurinomas, and ependymomas can accomplish this conversion. The synthetic pathway in the tumors appears to be similar to that in normal liver tissue. Cholesterol biosynthesis in human central nervous system tumors is inhibited by oral administration of vanadium as diammonium oxytartratovanadate.
Validation Of a Brief Arsenic Trioxide (ATO)-Based Consolidation Chemotherapy In The Upfront Management Of Acute Promyelocytic Leukemia (APL): Less Anthracycline Exposure and Faster Completion Of Consolidation Therapy With Equivalent Survival
Authors: Mindy Leech, Moshe Stewart, Xu Zhang, Asad Bashey, H. Kent Holland, Scott R. Solomon, Hetty E Carraway, B. Douglas Smith, Lawrence E. Morris, Steven D. Gore, Amer M. Zeidan
Journal: Blood (2013)
The effect of patients' beliefs about their illnesses on compliance in psychotherapy
Authors: E F Foulks, J B Persons, R L Merkel
Journal: American Journal of Psychiatry (1986)

Sixty patients treated in the outpatient psychiatric clinic of a large urban teaching hospital were surveyed regarding their beliefs about the causes of their illness. Patients' beliefs were found to be related to two measures of compliance: number of visits and manner of termination from therapy. Subjects endorsing more medical and fewer nonmedical explanations for their illness made more visits to the clinic and ended treatment in a more compliant manner than did patients who endorsed more nonmedical beliefs about the causes of their illness. Results also showed that, except for age, demographic and diagnostic variables were not related to compliance.
Lung cancer screening white paper: a slippery step forward?
Authors: Hans-Ulrich Kauczor, Lorenzo Bonomo, Mina Gaga, Kristiaan Nackaerts, Nir Peled, Mathias Prokop, Martine Remy-Jardin, Oyunbileg von Stackelberg, Jean-Paul Sculier
Journal: European Respiratory Journal (2015)

Lung cancer kills, the more advanced the disease the lower the chance of survival and therefore early diagnosis is key to improve survival [1]. Recent data from the largest screening study, including more than 50 000 high-risk patients, shows benefit with lung cancer screening, while data from other studies are awaited [2]. The joint white paper published by the European Society of Radiology (ESR) and the European Respiratory Society (ERS) on lung cancer screening is not a general recommendation to perform lung cancer screening in Europe, but a recommendation on how to do it right and under what circumstances [3]. A lung cancer screening programme using CT will only yield positive effects if implemented properly with high quality <http://ow.ly/S1rGR>
Effect of Exercise on Lipoprotein Lipase Activity of Rat Heart, Adipose Tissue and Skeletal Muscle
Authors: E A NIKKILAE, P TORSTI, O PENTTILAE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2853: The Prevalence of Ion Channel Disorders in Victims of Sudden Adult Death Syndrome
Authors: Agnes C Chlebinska, Sandeep Basavarajaiah, Ann O’Sullivan, Sanjay Sharma
Journal: Circulation (2007)

Objectives: Sudden adult death syndrome (SADS) accounts for at least 4% of all sudden cardiac deaths in the United Kingdom and is often attributed to an ion channel disorder. The precise prevalence of and hence efficacy of effectiveness for screening for ion channel disorders utilising non-invasive cardiac tests in first degree relatives of victims of SADS is unknown. The aim of this study was to identify the prevalence of ion channel disorders in victims of SADS. Methods: Between March 2006 and March 2007, 17 families of victims of SADS were evaluated in a tertiary inherited cardiac clinic. A total of 46 individuals underwent 12-lead ECG, echocardiography, exercise stress testing, 24 hour Holter and, when applicable, an Ajmaline provocation test and/or cardiac magnetic resonance scan. Results: All family members had a structurally normal heart. An ion channel disorder was identified in 7 out of 17 (41%) families. Of these, 5 (71%) families exhibited the Brugada phenotype and 2 families manifested the long QT syndrome phenotype. A total of 11 of 46 (24%) asymptomatic family members were identified with an ion channel disorder. Conclusions: Non-invasive cardiac evaluation of first-degree family members of victims of SADS in a tertiary inherited cardiac diseases clinic suggests that ion channel disorders, particularly Brugada’s syndrome, account for at least 40% of all SADS deaths in the UK.
XC Cell Cytopathogenicity as an Assay for Murine Myeloma C-Type Virus 2
Authors: Loy E. Volkman, R. G. Krueger
Journal: JNCI Journal of the National Cancer Institute (1973)

An adaptation of the XC cell cytopathogenicity test for detection of murine leukemia virus (MuLV) and MuLV-infected cells was used for assaying murine myeloma C-type virus. Fusion-inducing activity was present in MOPC-21 and FLOPC-1 (filter-Lucite-originated plasma cell tumor) cell culture lines, as well as in the gradient-purified C-type virus. Activity was not present in MOPC-21 and FLOPC-1 cells from in vivo tumors, which corresponded with electron microscopic evidence that the in vivo tumor cells were devoid of any C-type virus. Syncytium formation induced by cells or purified virus was not prevented by treatment with several inhibitors of macromolecular synthesis. However, extracellular fusion-inducing activity was sensitive to temperature, trypsin, ether, ultraviolet light, and RNAse.
Further Studies on the Relation of the Mammary-Tumor Agent to Mammary Tumors of Hybrid Mice
Authors: Howard B. Andervont, Thelma B. Dunn
Journal: JNCI Journal of the National Cancer Institute (1948)

Further Studies on the Relation of the Mammary-Tumor Agent to Mammary Tumors of Hybrid Mice Get access Howard B. Andervont, Howard B. Andervont biologist Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn Thelma B. Dunn pathologist National Cancer Institute, National Institute of Health, Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 2, October 1948, Pages 89–104, https://doi.org/10.1093/jnci/9.2.89 Published: 01 October 1948 Article history Received: 07 June 1948 Published: 01 October 1948
Orotracheal Intubation
Authors: Christopher Kabrhel, Todd W Thomsen, Gary S Setnik, Ron M Walls
Journal: New England Journal of Medicine (2007)

Emergency orotracheal intubation is indicated in any situation in which definitive control of the airway is needed. Specific indications include cardiac or respiratory arrest, failure to protect the airway from aspiration, inadequate oxygenation or ventilation, and impending or existing airway obstruction. Orotracheal intubation is also commonly performed as part of the care of the critically ill patient with multisystem disease or injuries, and to facilitate control of the airway during surgical procedures requiring general anesthesia. Contraindications: In emergent cases, such as cardiac arrest, airway management is of paramount importance, and there are very few contraindications to orotracheal intubation. Unstable . . . .
Effect of Diets Deficient in Certain Amino Acids on the Induction of Leukemia in DBA Mice&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Julius White, Florence R. White, G. Burroughs Mider
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Effect of Diets Deficient in Certain Amino Acids on the Induction of Leukemia in DBA Mice Get access Julius White, Julius White principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service and the University of Rochester School of Medicine and Dentistry, Department of Surgery, Rochester, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Florence R. White, Florence R. White biochemist National Cancer Institute, National Institute of Health, United States Public Health Service and the University of Rochester School of Medicine and Dentistry, Department of Surgery, Rochester, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar G. Burroughs Mider G. Burroughs Mider National Cancer Institute, National Institute of Health, United States Public Health Service and the University of Rochester School of Medicine and Dentistry, Department of Surgery, Rochester, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 199–202, https://doi.org/10.1093/jnci/7.4.199 Published: 01 February 1947 Article history Received: 14 January 1947 Published: 01 February 1947
Natural interferon-alpha versus its combination with 6-methyl- prednisolone in the therapy of type II mixed cryoglobulinemia: a long- term, randomized, controlled study
Authors: F Dammacco, D Sansonno, JH Han, V Shyamala, V Cornacchiulo, AR Iacobelli, G Lauletta, R Rizzi
Journal: Blood (1994)
Low-Flow Aortic Stenosis After Transcutaneous Aortic Valve Replacement
Authors: James D. Thomas
Journal: JAMA Cardiology (2016)

Venkatesh Y. Anjan, MD; Howard C. Herrmann, MD; Philippe Pibarot, PhD; William J. Stewart, MD; Samir Kapadia, MD; E. Murat Tuzcu, MD; Vasilis Babaliaros, MD; Vinod H. Thourani, MD; Wilson Y. Szeto, MD; Joseph E. Bavaria, MD; Susheel Kodali, MD; Rebecca T. Hahn, MD; Mathew Williams, MD; D. Craig Miller, MD; Pamela S. Douglas, MD; Martin B. Leon, MD
GP struck off for making false claims under quality and outcomes framework
Authors: Clare Dyer
Journal: BMJ (2016)

A Scottish former GP has been struck off the medical register for dishonesty after making false claims for incentive payments under the quality and outcomes framework (QOF), the scheme set up to reward GP practices for providing improved primary care.

Nigel Ostrowski, then senior partner at Bangholm Medical Centre in Edinburgh, said that he had seen patients with chronic illnesses and reviewed their health, then made false entries in their medical records.

A medical …
Response to letter, ‘Immortal time bias in retrospective analysis’
Authors: M A Dimopoulos, A S Swern, J S Li, M Hussein, L Weiss, Y Nagarwala, R Baz
Journal: Blood Cancer Journal (2015)

We appreciate the response from Hsieh et al. 1 to our publication, 'Efficacy and safety of long-term treatment with lenalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma'. 2As a part of our original study, we assessed the effect of lenalidomide and dexamethasone treatment on 'humoral improvement' in multiple myeloma patients, which was defined as an increase in uninvolved immunoglobulin A levels from baseline.We found that, compared with humoral nonresponders whose mean immunoglobulin A levels remained unchanged, humoral responders to lenalidomide and dexamethasone treatment showed improvements in long-term outcomes such as progression-free survival (PFS) and overall survival (OS), as determined by log-rank tests (P o 0.0001 for PFS and OS; Figures 2a andb).In the letter by Hsieh et al., 'Immortal time bias in retrospective analysis', 1 the group questions the use of log-rank tests (or Cox regression models using response as a timeindependent covariate), and remarks that this could have resulted in 'immortal time bias '. 3 In this context, this means that a bias towards improved outcomes may have occurred in the humoral responder patient group, dependent on the longer observation time in that group.In other words, patients who remained alive and progression-free had a higher chance of achieving a humoral response.Humoral response rate was 79% in patients experiencing longterm benefit of therapy (PFS ⩾ 3 years) versus other patients (54%; P = 0.006); however, median time to humoral response was 1 month in both groups.To address the concerns of Hsieh et al., 1 we reanalyzed PFS and OS using humoral response as a time-dependent covariate, as suggested.Following reanalysis, humoral response in patients receiving lenalidomide and dexamethasone was again found to be a highly significant determinant of patient outcome.Comparing humoral responders and nonresponders revealed significant differences in PFS (hazard ratio 0.59, 95% confidence interval 0.43-0.82;P = 0.0016) and OS (hazard ratio 0.55, 95% confidence interval 0.40-0.76;P = 0.0003).Humoral responders had a 41% reduction in the risk of progression or death and a 45% risk reduction in death.This time-dependent analysis confirms that humoral response significantly predicts the long-term benefit of lenalidomide and dexamethasone therapy for patients with relapsed/refractory multiple myeloma, in agreement with the original conclusions of the paper.
A human case of travel-related rabies in Austria, September 2004
Authors: R Strauss, A Gränz, M Wassermann-Neuhold, R Krause, Z Bago, S Revilla-Fernández, F Simón-Soria, J E Echevarria, T Popow-Kraupp, F Allerberger, M Schönbauer, H Hrabcik
Journal: Eurosurveillance (2005)

A young male Austrian tourist, aged 23 years and unvaccinated against rabies, was bitten by a dog in Morocco in July 2004. One month later he was hospitalised in Ceuta with symptoms compatible with rabies. He died on 23 September in an Austrian hospital after a diagnosis of rabies was confirmed by FAT, IHC and RT-PCR (including sequencing) of the neck skin and the RT-PCR (including sequencing) of the pharyngeal swab. This Austrian case of laboratory confirmed rabies highlights the urgent need for reinforcement of the international recommendations for travel vaccinations.