tbuckley/cabot-search huggingface dataset:
Antibodies to Epstein-Barr Virus-Associated Antigens in Relatives of Cancer Patients2
Authors: Paul H. Levine, Joseph F. Fraumeni, Joel I. Reisher, Deward E. Waggoner
Journal: JNCI Journal of the National Cancer Institute (1974)

Elevated antibody levels to Epstein-Barr virus (EBV)-associated antigens in patients with infectious mononucleosis (IM) and lymphomas implicated EBV in the etiology of these diseases. Only in IM, however, has an etiologic role for EBV been documented. In lymphoma patients, therefore, EBV titers could be a result of the disease process or a marker of susceptibility to another oncogenic factor rather than a specific response to a suspected etiologic agent (EBV). To investigate these possibilities, sera were collected from 21 families with multiple cases of cancer, including lymphomas, which permitted the prospective evaluation of normal individuals at high risk of developing tumors. Antibody levels to the EBV capsid antigen and early antigen were significantly higher in the 83 infected members of multiple-case families than in 144 normal controls. The differences between the cancer families and the controls were most prominent in individuals under the age of 20, since antibody to EBV-associated antigens appears higher in older individuals. Antibody titers were higher in families where the prominent tumor types were carcinoma and soft-tissue sarcoma as well as lymphoma. High EBV titers in certain individuals, rather than reflecting a recent infection with EBV, may represent an abnormal immune response perhaps related to a familial susceptibility to cancer.
Use of a Duodenoscope in the Management of a Ureteral Calculus in a Patient with Ureterosigmoidostomy (Mainz Pouch II; Rectosigmoid Pouch)
Authors: P. Mosler, R. Kiesslich, R. Stein, P. Galle, J. Thüroff, S. Kanzler
Journal: Endoscopy (2003)

Mainz pouch II (modified ureterosigmoidostomy) is an established technique for permanent urinary diversion in patients with congenital malformations or acquired diseases of the bladder [1]. If urolithiasis occurs, an effective and minimally invasive therapy is mandatory. Extracorporeal shock-wave lithotripsy and surgical procedures are frequently used treatment strategies [2]. Retrograde endoscopic management is an alternative option, which has been reported rarely.
Elevated CSF levels of interleukin-2 in neuroleptic-free schizophrenic patients
Authors: J Licinio, J P Seibyl, M Altemus, D S Charney, J H Krystal
Journal: American Journal of Psychiatry (1993)

Levels of CSF fluid interleukin-2, but not interleukin-1 alpha, were found to be higher in 10 neuroleptic-free schizophrenic patients than in 10 healthy subjects matched for sex and age. Because interleukin-2 increases dopaminergic neurotransmission and participates in autoimmunity and cell growth, the authors postulate that elevated levels of central interleukin-2 might contribute to the increased dopaminergic neurotransmission, autoimmune phenomena, and abnormal brain morphology described in some patients with schizophrenia.
Complications of Colonic Stenting: A Case of Stent Migration and Fracture
Authors: N. Suzuki, B. Saunders, S. Thomas-Gibson, M. Marshall, S. Halligan, J. Northover
Journal: Endoscopy (2003)

A 67-year-old woman underwent stent insertion (Wallstent 22 mm diameter, 6 cm long, Schneider, Bulach, Switzerland) for obstructing, metastatic, sigmoid colon cancer. Although abdominal decompression was achieved, the stent migrated to the rectum on the second day. After retrieval of the displaced stent using manual traction and gentle anal dilation without anaesthesia, another stent (Memotherm 30 mm diameter, 10 mm long, Bard, Karlsruhe, Germany) was inserted.
Psychiatric comorbidity in patients with generalized anxiety disorder
Authors: O Brawman-Mintzer, R B Lydiard, N Emmanuel, R Payeur, M Johnson, J Roberts, M P Jarrell, J C Ballenger
Journal: American Journal of Psychiatry (1993)

The goal of this study was to test the validity of generalized anxiety disorder as an independent diagnostic entity and to evaluate the prevalence and type of other psychiatric disorders coexisting with generalized anxiety disorder. Although a few published studies have addressed the subject, this study presents data from a larger group of subjects and excludes concurrent major depression as a potential confound.The authors studied patients with a primary diagnosis of generalized anxiety disorder assigned after evaluation with the Structured Clinical Interview for DSM-III-R. Patients with a concurrent major depressive episode were excluded. All diagnoses for which the patient met criteria were determined, including lifetime occurrence of major depressive episode and substance use.One hundred nine patients with generalized anxiety disorder were included in the analysis. Twenty-eight (26%) of these patients were not given any other lifetime psychiatric diagnosis. The most prevalent comorbid diagnoses were social phobia (25 [23%] of the patients) and simple phobia (23 [21%] of the patients). Forty-six (42%) of the patients with generalized anxiety disorder had experienced at least one major depressive episode during their lifetime.These results support previous findings of high rates of psychiatric comorbidity in generalized anxiety disorder and validate the usefulness of generalized anxiety disorder as a separate diagnostic entity.
The pathology of chronic oesophagitis
Authors: R. J. Sandry
Journal: Gut (1962)

This paper reports the results of a histological study of severe chronic oesophagitis. The material consisted of 46 specimens removed by oesophagogastrectomy. Two distinct types of lesion were found: chronic superficial oesophagitis and localized penetrating ulceration, the latter being found closely related to intrusions of gastric cardiac type (mucosa) into the lower oesophagus.
SAT0006 High Systemic LDL Cholesterol Levels Lead to Synovial Activation and Strongly Accelerate Development of Ectopic Bone Formation During Experimental Osteoarthritis
Authors: W. de Munter, M.H. van den Bosch, S.W. Annet, K. Croce, N. Hogg, T. Vogl, J. Roth, W.B. van den Berg, P.M. van der Kraan, P.L. van Lent
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> A relation between osteoarthritis (OA) and increased cholesterol levels is apparent. <h3>Objectives</h3> In the present study we investigate OA pathology in apolipoprotein E-deficient (ApoE<sup>-/-</sup>) mice with and without a cholesterol-rich diet, a model for high systemic low density lipoprotein (LDL) cholesterol levels independent of weight. <h3>Methods</h3> Wild type (WT), ApoE<sup>-/-</sup>, S100A9<sup>-/-</sup> and ApoE<sup>-/-</sup>S100A9<sup>-/-</sup> mice received a standard or cholesterol-rich diet. Experimental OA was induced by intra-articular injection of collagenase and animals were sacrificed at day 10 and 36. Joint pathology was investigated by immunohistochemistry and RNA expression and protein production by synovium were determined using RT-PCR and luminex, respectively. Data are depicted as mean ± standard deviation. <h3>Results</h3> Although minimal differences in cartilage damage were found between the WT and ApoE<sup>-/-</sup> mice, an increase in synovial thickening was found in the latter. At end-stage OA, ApoE<sup>-/-</sup> mice on a standard diet showed increased ectopic bone formation, particularly at the medial collateral ligament, compared to OA in WT mice. Furthermore, a significant increase in synovial gene expression of both S100A8 and S100A9 and S100A8/S100A9 protein levels was found in ApoE<sup>-/-</sup> mice as well as increased levels of the chemokine KC, suggesting an activated inflammatory status of synovial cells. In both ApoE<sup>-/-</sup> and WT mice, addition of a cholesterol-rich diet resulted in excessive bone formation in the medial collateral ligament at end point. Interestingly, at the early time point, proteoglycan-deposition was already significantly increased in ApoE<sup>-/-</sup> mice compared with WT mice. Mice deficient for both ApoE and S100A9 also showed increased ectopic bone formation, but no increase in KC-levels, suggesting a role for S100-proteins in cholesterol-mediated synovial activation. <h3>Conclusions</h3> Increased cholesterol levels result in synovial activation and ectopic bone formation in experimental OA. Excessive LDL levels strongly elevate synovial activation and ectopic bone formation in early-stage collagenase-induced OA. <h3>Disclosure of Interest</h3> None declared
Psychiatric effects of prolonged Asian captivity: a two-year follow-up
Authors: R C Hall, P T Malone
Journal: American Journal of Psychiatry (1976)

The authors have been following a group of 6 prisoners of war and their families since the men were returned from North Viet Nam. They found that most of the men experiences cognitive, social, work, emotional, and family difficulties during the first two years after their return. However, most of these problems were resolved after two years, and there was no evidence of the concentration camp syndrome, homicidal or suicidal behavior, violent physical aggression, impotence, fugue states, psychosomatic disorders, or major psychiatric illnesses in any of the men. On the basis of their findings, the authors make recommendations for future reentry programs.
Adverse Effects of Activated Cytotoxic T Lymphocytes on the Clinical Outcome of Nodal Anaplastic Large Cell Lymphoma
Authors: Rosita L. ten Berge, Danny F. Dukers, Joost J. Oudejans, Karen Pulford, Gert J. Ossenkoppele, Daphne de Jong, Jo F.M.M. Miseré, Chris J.L.M. Meijer
Journal: Blood (1999)
The fiscal crisis in New York City: effects on the mental health care of minority populations
Authors: P Ruiz
Journal: American Journal of Psychiatry (1979)

The author describes the effect that severe budget cuts accompanied by guidelines stipulating that direct services be given priority over primary preventive services had on a community mental health center in New York City. He focuses his discussion on the effect these guidelines had on the mental health care services provided the minority populations served by the center. Before the budget cuts, 1 out of every 4 staff members was a nonprofessional indigenous worker. After the cutback, 2 out of every 3 of the people laid off were nonprofessionals. The author provides a number of recommendations to help government agencies plan budget reductions without sacrificing primary prevention efforts.
Beyond the Ebola Battle — Winning the War against Future Epidemics
Authors: Victor J. Dzau, Peter Sands
Journal: New England Journal of Medicine (2016)

The battle to contain and defeat the recent Ebola epidemic was won at immense cost. It would be a huge mistake to turn away and declare the war over; West Africa remains vulnerable to a resurgence, and there will undoubtedly be outbreaks of other infectious diseases.
SAT0462 Mortality and Main Causes of Death in a Multicenter Cohort of Inflammatory Idiopathic Myositis
Authors: L. Nuño, F.J. Lopez Longo, B. Joven, V. Maldonado, L. Ruiz, P. García de la Peña, I. Llorente, C. Barbadillo, H. Moruno, T. Cobo, L. Lojo, R. Almodovar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Clinical manifestations and prognosis of idiopathic inflammatory myopathies (IIM) are extremely heterogeneous which, combined with its low prevalence, makes difficult the study of the disease in the absence of multicenter studies. <h3>Objectives</h3> To analyze the clinical characteristics and mortality in a cohort of patients diagnosed with IIM in rheumatology units from several hospitals in Madrid. <h3>Methods</h3> A multicenter retrospective longitudinal descriptive study from REMICAM myositis study group was performed. All patients diagnosed with IIM according to Bohan and Peter<sup>1</sup> criteria for myositis and in follow-up sometime between January 1980 and December 2014 in rheumatology units were included. Patients were classified into clinical subgroups: primary dermatomyositis (DM), primary polymyositis (PM), juvenile dermatomyositis (JDM), paraneoplasic myositis, overlap myositis (OM), inclusion body myositis (IBM) and necrotizing myositis (NM). Main causes of death and influence of age and sex were studied. <h3>Results</h3> 485 cases were included in this study, with a medium age at diagnosis of 43,3±23,2 years and mean follow-up time of 11,3±19 years. Most cases were Caucasian (93%), and women (74,4%). The most frequent form of classification were primary myopathies (28,8% PM; 21% DM; 20,6% OM; 19,4% JDM; 8,3% paraneoplasic myositis; 1% IBM and 0.8% NM) and the most frequent myositis specific antibodies detected were anti-Jo-1 (16,3% anti-Jo-1; 4,1% anti-Mi-2; 2,7% anti-PM-Scl; 0,6% anti-SRP; 0,2% anti-Ku). 25,4% of patients died, with a higher mortality rate in men (32,5% vs. 22,9; p=0,04) and older age at onset (54,1±24,8 years vs. 37,2±26,4 years, p&lt;0,001). The clinical subtypes with higher mortality were paraneoplasic myositis (70%) and OM (36%). Main causes of death were cancer (23,4%) and cardiovascular events (23,4%), followed by infections (22,4%), interstitial lung disease (7.5%) and other causes. In clinical subsets, main causes of death were infections in DM (37,5%), and cardiovascular disease in OM (32,3%) and PM (32,1%). <h3>Conclusions</h3> In our cohort of IIM 25,4% of patients died, with a worse prognosis in men and older age at onset, mainly due to cancer and cardiovascular events. Cardiovascular events are the most important cause of death in PM and MCTD, and infections in DM. <h3>References</h3> Bohan A, Peter JB. N Engl J Med 1975 Feb 13;292(7):344-7. <h3>Disclosure of Interest</h3> None declared
The role of second and third line tyrosine kinase inhibitor monotherapy in EGFR wild-type (and unknown mutational status) advanced non-small-cell lung cancer patients: Findings from a retrospective analysis
Authors: G. Bronte, T. Franchina, M. Alù, G. Sortino, C. Celesia, F. Passiglia, S. Giuseppina, L. Agata, R. Alessandro, A. Picone, S. Rizzo, L. Blasi, V. Adamo, A. Russo
Journal: Annals of Oncology (2015)
Herpes Simplex Encephalitis
Authors: J M Zajkowska, T Hermanowska-Szpakowicz, S A Pancewicz
Journal: New England Journal of Medicine (1981)

Herpes simplex virus infection of the central nervous system is still a significant cause of morbidity and often mortality. Changes of central nervous system are results of primary infection or activation of latent HSV-1, HSV-2. Neurological deficits often follow encephalitis herpetica. The application of PCR is prompt and specific diagnosis of herpes simplex virus infections of the brain. Advances in treatment herpes simplex encephalitis with acyclovir have improved outcome.
Regulation of Effector Treg Cells in Murine Lupus
Authors: Uma Chandrasekaran, Woelsung Yi, Sanjay Gupta, Chien‐Huan Weng, Eugenia Giannopoulou, Yurii Chinenov, Rolf Jessberger, Casey T. Weaver, Govind Bhagat, Alessandra B. Pernis
Journal: Arthritis & Rheumatology (2016)

Treg cells need to acquire an effector phenotype to function in settings of inflammation. Whether effector Treg cells can limit disease severity in lupus is unknown. Interferon regulatory factor 4 (IRF-4) is an essential controller of effector Treg cells and regulates their ability to express interleukin-10 (IL-10). In non-Treg cells, IRF-4 activity is modulated by interactions with DEF-6 and its homolog switch-associated protein 70 (SWAP-70). Although mice lacking both DEF-6 and SWAP-70 (double-knockout [DKO] mice) develop lupus, they display normal survival, suggesting that in DKO mice, Treg cells can moderate disease development. The purpose of this study was to investigate whether Treg cells from DKO mice have an increased capacity to become effector Treg cells due to the ability of DEF-6 and SWAP-70 to restrain IRF-4 activity.Treg cells were evaluated by fluorescence-activated cell sorting. The B lymphocyte-induced maturation protein 1 (BLIMP-1)/IL-10 axis was assessed by crossing DKO mice with BLIMP-1-YFP-10BiT dual-reporter mice. Deletion of IRF-4 in Treg cells from DKO mice was achieved by generating FoxP3(Cre) IRF-4(fl/fl) DKO mice.The concomitant absence of DEF-6 and SWAP-70 led to increased numbers of Treg cells, which acquired an effector phenotype in a cell-intrinsic manner. In addition, Treg cells from DKO mice exhibited enhanced expression of the BLIMP-1/IL-10 axis. Notably, DKO effector Treg cells survived and expanded as disease progressed. The accumulation of Treg cells from DKO mice was associated with the up-regulation of genes controlling autophagy. IRF-4 was required for the expansion and function of effector Treg cells from DKO mice.This study revealed the existence of mechanisms that, by acting on IRF-4, can fine-tune the function and survival of effector Treg cells in lupus. These findings suggest that the existence of a powerful effector Treg cell compartment that successfully survives in an unfavorable inflammatory environment could limit disease development.
Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone
Authors: D Puthier, R Bataille, S Barille, MP Mellerin, JL Harousseau, A Ponzio, N Robillard, J Wijdenes, M Amiot
Journal: Blood (1996)
Concurrent validation of a diagnostic interview for borderline patients
Authors: P H Soloff
Journal: American Journal of Psychiatry (1981)

Further study is needed to determine lithium’s effect on seizure disorders. The varying results mentioned above could be explained on the basis of drug-drug interactions or a differential effect on different seizure types. This case report demonstrates that lithium may dramatically increase the frequency of petit mal seizunes. Whether lithium would have the same effect on
AB0112 Differences in Serum Biomarker Profiles of Anti-Citrullinated Protein Antibody-Positive and Anti-Citrullinated Protein Antibody-Negative Rheumatoid Arthritis
Authors: A. Novikov, E. Aleksandrova, D. Karateev, E. Lutchihina, T. Popkova, M. Cherkasova, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Comparative data on serum biomarker profile in anti-citrullinated peptide/protein antibody positive (ACPA+) and ACPA negative (ACPA-) rheumatoid arthritis (RA) patients are scarce. <h3>Objectives</h3> Our aim was to analyze serum levels of proteomic biomarkers in patients with RA according to the presence or absence of ACPA. <h3>Methods</h3> We examined serum samples from 118 pts: 37 with early RA (&lt;6 months disease duration, median and interquartile range (25th–75th percentile) of age 51 (41-62) years, 76% female, 79% ACPA+); 81 with established RA (&gt;6 months disease duration, 49 (41-57) years, 88% female, 79% ACPA+). Patients were defined as ACPA - if serum was negative to three different ACPAs (second anti-CCP2, anti-MCV, anti-keratin antibodies). Anti-CCP2, anti-MCV, IgA RF was measured by ELISA; anti-keratin antibodies by indirect immunofluorescence assay; IgM RF by immunonephelometry. Cytokine analyses were performed with multiplex technology (Human Grp I Cytokine 27-plex panel for BioPlex 200). <h3>Results</h3> ACPA+ with early RA had significantly higher levels of IgM RF, IL-15, G-CSF, with established RA – IgM/IgA RF, TNF-α, IL-15, -1ra, -2, -5, -9-10, -12, eotaxin, GM-CSF, MCP-1 than ACPA pts. <h3>Conclusions</h3> ACPA+ patients had higher levels of RF, anti- and pro-inflammatory cytokines, colony-stimulating factors and chemokines than ACPA- patients. <h3>Disclosure of Interest</h3> None declared
Lymphoscintigraphic Sentinel Node Imaging and Gamma Probe Detection in Breast Cancer with Tc-99m Nanocolloidal Albumin
Authors: THOMAS RINK, THOMAS HEUSER, HARTMUT FITZ, HANS-JOACHIM SCHROTH, ESRA WELLER, HANS H. ZIPPEL
Journal: Clinical Nuclear Medicine (2001)

The purpose of this study was to aid in the standardization of lymphoscintigraphy for detecting the sentinel node (SN) in breast cancer using Tc-99m-labeled nanocolloidal albumin.One hundred twenty-three women with proved breast cancer were enrolled. Four injections of 10 to 15 MBq (0.27 to 0.41 mCi) Tc-99m nanocolloid in 0.1 ml physiologic saline were administered intra- and subdermally at the margin of the skin overlying the tumor. Planar scintigraphic images in the lateral and anterior projections were obtained 2.5 to 18 hours after tracer administration. With a gamma probe used as a guide, all radioactive lymph nodes in the axilla were resected. Complete dissection then followed.In 116 of the 123 (94%) women, axillary nodal tracer uptake was revealed. Six of the 7 women in whom detection failure occurred had histologically proved tumor infiltration of the lymphatics and axillary involvement. In 36 (31%) of the patients with visualized lymph nodes, the SN was metastatic. The remaining 80 patients with negative SN included three cases with axillary involvement. The sensitivity of the SN with respect to the histologic status of the entire axilla thus was 92.3%, and the negative predictive value was 96.3%. The overall accuracy of the method was 97.4%. The number of hot nodes in women with and without axillary involvement was significantly different.The described protocol represents an easily reproduced and reliable method for SN detection in breast cancer. Furthermore, the number of visualized axillary nodes reflects the histologic status of the axilla.
Screening for Osteoporosis
Authors: Gary F Cunningham
Journal: New England Journal of Medicine (2005)

1975 ture had levels below 15 ng per milliliter, and that among all postmenopausal women in the metaanalysis, up to 86 percent had levels below 20 ng per milliliter. 2 However, there was significant heterogeneity in the populations studied with regard to the prevalence of vitamin D deficiency. I agree that to consider a patient as having vitamin D deficiency, the cutoff should be higher than 15 ng per milliliter, although whether it should be 20, 25, or 30 ng per milliliter is still being debated. 3 Clifford J. Rosen, M.D.
Concerning Antisense Inhibition of the Multiple Drug Resistance Gene
Authors: J W Jaroszewski, O Kaplan, J L Syi, M Sehested, P J Faustino, J S Cohen
Journal: Cancer Communications (1990)

Recently, Vasanthakumar and Ahmed reported (Vasanthakumar, G.; Ahmed, N.K., Cancer Communications 1:225-232; 1989) a complete inhibition of the multiple drug resistance gene (MDR1) in the K562/III erythroleukemia cells, using a 15 bases-long methylphosphonate oligodeoxynucleotide analog. The sequence used, however, contained three mismatches relative to the corresponding fragment of the human MDR1 gene and, hence, the results reported cannot at present be regarded as a classical antisense effect. We have made attempts to inhibit the expression of the MDR1 gene in MCF-7 human breast cancer cells selected for resistance to Adriamycin using phosphorothioate analogs of oligodeoxynucleotides. Studies with model 35S-labeled-phosphorothioates indicated poor uptake of the compounds into the cells; the radioactivity was located mainly in the soluble fraction (cytoplasm), but membranes and the nuclear fraction were also labeled. Unmodified oligodeoxynucleotides were toxic to the cells, whereas the phosphorothioates were not. The MDR1 inhibition with phosphorothioates was studied by measuring their effects on adriamycin toxicity and by immunocytochemical titration of P170. Elevation of adriamycin cytotoxicity consistent with a decreased drug resistance was observed with one antisense sequence, but the immunocytochemical assay indicated only slight inhibition of the synthesis of P170. In the wild type (drug sensitive) MCF-7 cells phosphorothioates decreased adriamycin toxicity in a sequence-independent manner. The results indicate that the effects of antisense oligodeoxynucleotides on cells are complex. Computer simulation of the secondary structure of MDR1 mRNA indicated not only extensive folding but, also, the presence of many regions not involved in intramolecular hybridization, which are of potential interest as targets for antisense oligodeoxynucleotides.