tbuckley/cabot-search huggingface dataset:
Characteristics of first relapse in stage III melanoma patients with no evidence of disease (NED): Guidelines for follow-up
Authors: E. Romano, M. Scordo, P. Chapman
Journal: Journal of Clinical Oncology (2009)

9069 Background: Follow up (F/U) of patients (pts) with AJCC stage III melanoma but with NED is currently empiric with respect to frequency of clinical exams, F/U duration, and diagnostic tests. Data-based F/U guidelines are needed. Methods: Clinical records of 429 pts with stage III NED pts seen at MSKCC between 1998 and 2002 and who ultimately relapsed were reviewed retrospectively to evaluate: site and date of 1st relapse, interval between the stage III NED and 1st relapse; how the 1st relapse was detected, date of death or last F/U. We also determined the overall 5 yr relapse-free survival (RFS) of all stage III pts seen at MSKCC during this period. Results: The overall 5 yr RFS for stage IIIA, B, and C patients at MSKCC was: 52%, 29%, and 15%, respectively. Among the relapsing pts, 280 had adequate F/U to be evaluable for all parameters (35 stage IIIA, 155 stage IIIB, 90 stage IIIC). The site of 1st relapse was local/in-transit (28%), regional nodal (20%), or systemic sites (52%). The most common sites of 1 st systemic relapse were lung, liver, brain. There were significant differences among substages. First relapses were detected by the pt or family, MD, or by screening radiological tests in 52%, 19%, and 29% of cases, respectively. Multivariate analysis revealed better overall survival (OS) was not associated with time to relapse but was associated with younger age and if 1st relapse was: a) local/in-transit or nodal, b) asymptomatic, or c) resectable. By noting when the risk for 1st local/intransit, nodal, or systemic (lung, liver, brain) relapse became sufficiently low (&lt;5%) for each substage, we generated tentative F/U guidelines ( Table ). Conclusions: Our data suggest that F/U strategies for stage III should be adapted by substage and indicate time ranges beyond which more prolonged F/U would be unlikely to benefit pts. Whether frequent F/U within these time ranges can increase the chances of complete surgical resection or improve OS is not known. [Table: see text] No significant financial relationships to disclose.
Reply:
Authors: Dahee Choi, Kyoung-Jin Oh, Seung-Hoi Koo
Journal: Hepatology (2012)

As Xu etal. stated,1 the previous study by Krones-Herzig etal. clearly demonstrated the functional significance of protein arginine methyltransferase-4 [PRMT4; also known as coactivator-associated arginine methyltransferase-1 (CARM-1)]-dependent regulation of hepatic glucose production in cultured hepatocytes.2 Specifically, they showed that PRMT4 was recruited to the cyclic adenosine monophosphate (cAMP) response element of promoters of both phosphoenol pyruvate carboxykinase (PEPCK) and glucose 6-phosphatase catalytic subunit (G6Pase), which resulted in the increased methylation of arginine 17 on histone H3 and acetylation of histone H4. These results indicated that cAMP response element-binding protein (CREB) might recruit PRMT4 and other known histone acetyltransferases, such as CREB-binding protein (CBP)/p300, onto the promoters of gluconeogenic genes. Indeed, phosphorylation of serine 133 of CREB by cAMP-dependent protein kinase is a key mechanism for the recruitment of CBP/p300 and subsequent activation of CREB-target gene transcription.3 Although we showed that protein arginine methyltransferase-1 (PRMT1) is critical in activating FoxO1-dependent gluconeogenesis by promoting arginine methylation of FoxO1,4 we failed to detect any PRMT1-dependent increase in arginine methylation of histone H3 or H4, at least using the adenovirus-mediated overexpression system in hepatocytes (data not shown). Indeed, we suspect that FoxO1-dependent transcriptional activation might be quite a bit more complicated, because CBP/p300, a potent histone acetyltransferase that normally activates transcription factors, was shown to be involved in the direct acetylation/inhibition of FoxO1.5 Furthermore, recent studies also indicated that histone deacetylase 3 was recruited onto the FoxO1-binding sites of both PEPCK and G6Pase in primary hepatocytes,6 suggesting that certain regions of gluconeogenic promoters might be potentially hypoacetylated. Currently, we are in the process of generating liver-specific knockout mice for PRMT1 to directly address this issue. Further studies utilizing this mouse model will be helpful to decipher the complex histone codes in the regulation of hepatic gluconeogenic gene expression. Dahee Choi B.S.*, Kyoung-Jin Oh Ph.D.*, Seung-Hoi Koo Ph.D.*, * Division of Biochemistry and Molecular Biology, Department of Molecular Cell Biology and Samsung Biomedical Institute, Sungkyunkwan University School of Medicine, Suwon, Korea.
AB1178 Spectrum of Rheumatic Diseases Associated with Primary Immunodeficiencies
Authors: S. Blazina, G. Markelj, N. Toplak, M. Debeljak, T. Avčin
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Primary immunodeficiency (PID) can present as rheumatic disease due to improper immune regulation. <h3>Objectives</h3> Study objective was to evaluate prevalence of rheumatic diseases in Slovene patients with PID. <h3>Methods</h3> Medical records of patients entered in Slovene PID registry were reviewed. Data on rheumatic disease and PID were collected and analysed. <h3>Results</h3> 240 patients with 49 different PIDs are registered in Slovene PID registry. At least one rheumatic disease is diagnosed in 12 (5%) patients in Slovene PID registry. Five different rheumatic diseases were diagnosed: juvenile idiopathic arthritis (6 patients), rheumatoid arthritis (2 patients), skin vasculitis (2 patients), systemic lupus erythematosus (1 patient) and Kawasaki disease (1 patient). Rheumatic disease was the presenting manifestation of PID in 8 patients. Four patients developed rheumatic disease after PID has been diagnosed. Rheumatic disease was present in 5 out of 19 patients with IgA deficiency, 3 patients with yet undefined PID, 2 out of 12 patients with CVID, 1 out of 3 patients with autoimmune lymphoproliferative syndrome and 1 out of 13 patients with DiGeorge syndrome. <h3>Conclusions</h3> Patients with PID do suffer from different rheumatic diseases. Therefore patients with rheumatic disease should be evaluated for possible underlying PID. Rheumatic diseases are most common in Slovene patients with predominantly antibody deficiencies which form the largest group of inherited disorders of immune system. Patients with PID should be screened for signs of autoimmunity when diagnosis of PID is made and during follow up. <h3>Disclosure of Interest</h3> None declared
Risk of reproductive complications following chlamydia testing: a population-based retrospective cohort study in Denmark
Authors: Bethan Davies, Katy M E Turner, Maria Frølund, Helen Ward, Margaret T May, Steen Rasmussen, Thomas Benfield, Henrik Westh
Journal: The Lancet Infectious Diseases (2016)

BackgroundUncertainty in the risk of reproductive complications (pelvic inflammatory disease, ectopic pregnancy, and tubal factor infertility) following chlamydia infection and repeat infection hampers the design of evidence-based chlamydia control programmes. We estimate the association between diagnosed chlamydia and episodes of hospital health care (inpatient, outpatient, and emergency department) for a reproductive complication.MethodsWe constructed and analysed a retrospective population-based cohort of women aged 15–44 years from administrative records in Denmark (1995–2012). We used a subset of the national Danish Chlamydia Study. The master dataset contains all residents of Denmark (including Greenland) who had a positive chlamydia test recorded by a public health microbiology laboratory from Jan 1, 1992, to Nov 2, 2011. Individuals were randomly matched (by age and sex) to four individuals drawn from the population register (Danish Civil Registration System) who did not have a positive chlamydia test during this interval. The outcomes in the study were hospital episodes of health-care (inpatient, outpatient, and emergency department) with a diagnosis of pelvic inflammatory disease, ectopic pregnancy, or tubal factor infertility.FindingsThe 516 720 women (103 344 positive, 182 879 negative, 230 497 never-tested) had a mean follow-up of 7·96 years. Compared with women with only negative tests, the risk of each complication was 30% higher in women with one or more positive tests (pelvic inflammatory disease, adjusted hazard ratio [AHR] 1·50 [95% CI 1·43–1·57]; ectopic pregnancy, AHR 1·31 [1·25–1·38]; tubal factor infertility, AHR 1·37 [1·24–1·52]) and 60% lower in women who were never-tested (pelvic inflammatory disease, AHR 0·33 [0·31–0·35]; ectopic pregnancy, AHR 0·42 [0·39–0·44]; tubal factor infertility AHR 0·29 [0·25–0·33]). A positive test had a minor absolute impact on health as the difference in the lifetime incidence of complications was small between women who tested positive and those who tested negative (pelvic inflammatory disease, 0·6%; ectopic pregnancy, 0·2%; tubal factor infertility, 0·1%). Repeat infections increased the risk of pelvic inflammatory disease by a further 20% (AHR 1·20, 95% CI 1·11–1·31).InterpretationA single diagnosed chlamydia infection increased the risk of all complications and a repeat diagnosed infection further increased the risk of pelvic inflammatory disease. Therefore, control programmes must prevent first and repeat infections to improve women's reproductive health.FundingUnrestricted partial funding from Frederiksberg Kommune, Frederiksberg, Denmark. BD held an Medical Research Council Population Health Scientist Fellowship (G0902120). KT held an National Institute for Health Research Post-Doctoral Fellowship 2009-02-055.
LABELING OF PRESCRIPTION DRUGS
Authors: W H Barnard
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Successful treatment of a proximal esophageal rupture with a luminal sponge
Authors: Michael Scharl, Nadine Stanek, Arne Kröger, Peter Bauerfeind, Christoph Gubler
Journal: Endoscopy (2015)

A 55-year-old man presented to the emergency department because of dysphagia. On admission, the patient reported retrosternal chest pain, and he was observed to be tachycardic and hypotensive. Physical examination showed soft-tissue emphysema over the sternal notch extending up to the neck bilaterally. Computed tomography identified a pneumomediastinum ([Fig. 1]).
Prognostic factors for time to progression and residual survival under second-line chemotherapy in advanced pancreatic cancer
Authors: C. Herrmann, U. Abel, W. Stremmel, D. Jaeger, T. Herrmann
Journal: Journal of Clinical Oncology (2008)

15631 Background: Second-line chemotherapy is widely used in advanced pancreatic cancer. However, only little data exist concerning the question which patients might benefit from second-line therapy. We intended to identify prognostic factors for time to second progression and rest survival under second-line chemotherapy of advanced pancreatic cancer. Methods: We performed a retrospective cohort study of 78 patients who started palliative chemotherapy at our department from January 2004 to June 2006 due to advanced adenocarcinoma of the pancreas. This analysis focusses on 46 patients who experienced progression under first-line therapy. Results: In multivariate analyses time to first progression below 6 months and elevated LDH at the time of diagnosis were shown to be strong and highly significant independent prognostic factors for time to second progression and residual survival. For patients with time to first progression shorter than 6 months the prognosis was poor with a median residual survival of 4.4 months versus 7.5 months for those with time to first progression of 6 months or more. Conclusions: In our cohort of patients with advanced pancreatic cancer who receive second-line chemotherapy, time to first progression below 6 months is a strong negative prognostic factor for time to second progression and residual survival. No significant financial relationships to disclose.
AB0646 Predicting Temporal Artery Biopsy Results… Offering Insights Into Temporal Arteritis Diagnosis
Authors: G.S. Jutley, A.S. Ahluwalia, T. Ali
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Biopsy of the temporal artery is considered fundamental to making the diagnosis of temporal arteritis. Besides carrying a significant false negative rate owing to skip lesions, the procedure has a small risk of significant complications including facial nerve injury<sup>1</sup>, scalp necrosis<sup>2</sup> and stroke<sup>3</sup>. The procedure may be contraindicated by delay in undertaking the biopsy from commencement of treatment, patient9s wishes or bleeding diathesis. <h3>Objectives</h3> To study the incidence of biopsy-proven temporal arteritis in the population surrounding Chesterfield Royal Hospital, United Kingdom. <h3>Methods</h3> A retrospective review of 235 consecutive patients who underwent a temporal artery biopsy in Chesterfield Royal Hospital from January 2009 to January 2015. Study variables included age at diagnosis, gender, CRP, ESR and ALP results prior to treatment. <h3>Results</h3> Among these 235 patients who underwent temporal artery biopsy, the mean age of those in the biopsy-positive group, 76.4 years (95% CI 73.8, 79.0), was higher than that of those in the biopsy-negative group, 70.4 (95% CI 69.0, 71.8). Using a two sample t-test, this generated a p value of 0.0002. A logistic regression model showed there is a statistically significant increase in the odds of a positive temporal artery biopsy of 1.072487 (CI 1.03045 to 1.116238) for every year increase of age, in addition to an odds increase of 1.022069 (CI 1.011327 to 1.032925) for every 1mm/hr increase in ESR. There was no statistical correlation between biopsy positive and biopsy-negative groups for CRP or ALP level; but a number patients had no CRP (97) or ALP (71) measured prior to diagnosis. <h3>Conclusions</h3> Our results show there is a significant increase of likelihood of a positive temporal artery biopsy as the patient9s age increases and the higher the value of ESR. Given a large enough sample, these results suggest that a scoring system may be created which can attempt to predict the likelihood of a positive temporal artery biopsy. This may be useful for patients in which temporal arteritis is suspected and biopsy is precluded. <h3>References</h3> Slavin ML. Brow droop after superficial temporal artery biopsy. Arch Ophthalmol 1986. 1041127. Dummer W, Zillikens D, Schulz A. et al. Scalp necrosis in temporal (giant cell) arteritis:implications for the dermatologic surgeon. Clin Exp Dermatol 1996. 21154–158.158. Haist SA. Stroke after temporal artery biopsy. Mayo Clin Proc 1985. 6053. <h3>Disclosure of Interest</h3> None declared
Enzyme Induction
Authors: Thomas D. Gelehrter
Journal: New England Journal of Medicine (1976)

Models of Enzyme InductionThe results presented in the preceding sections of this review did not appear to be compatible with a model of enzyme induction in which the inducer acts exclusively at the gene level to stimulate specific mRNA synthesis (as described below). Therefore, Tomkins and his colleagues presented a model in which the inducing steroids were thought to have a single action: to antagonize a labile post-transcriptional repressor, which both inhibits messenger translation and enhances messenger degradation.64,75,86 Since most models of the mechanism of enzyme induction in higher organisms have been based on models derived from the study . . .
Investigations on the Properties of Agents Causing Fowl Tumors. III. Attempts at Desiccation of the Fowl-Tumor Agents Freed from Extraneous Proteins&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: L DMOCHOWSKI
Journal: JNCI Journal of the National Cancer Institute (1948)

Investigations on the Properties of Agents Causing Fowl Tumors. III. Attempts at Desiccation of the Fowl-Tumor Agents Freed from Extraneous Proteins Get access L. Dmochowski L. Dmochowski Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 2, October 1948, Pages 73–75, https://doi.org/10.1093/jnci/9.2.73 Published: 01 October 1948 Article history Received: 08 December 1947 Published: 01 October 1948
Multidrug-resistant organisms detected in refugee patients admitted to a University Hospital, Germany June‒December 2015
Authors: Claudia Reinheimer, Volkhard A. J. Kempf, Stephan Göttig, Michael Hogardt, Thomas A. Wichelhaus, Fiona O’Rourke, Christian Brandt
Journal: Eurosurveillance (2016)

Multidrug-resistant Gram-negative bacteria (MDR GNB) were found to colonise 60.8% (95% confidence interval: 52.3–68.9) of 143 refugee patients mainly from Syria (47), Afghanistan (29), and Somalia (14) admitted to the University Hospital Frankfurt, Germany, between June and December 2015. This percentage exceeds the prevalence of MDR GNB in resident patients four–fold. Healthcare personnel should be aware of this and the need to implement or adapt adequate infection control measures.
STUDIES ON THE ANTIGENICITY OF ß- AND α1-LIPOPROTEINS OF HUMAN SERUM
Authors: Angelo Scanu, Lena A. Lewis, Irvine H. Page
Journal: The Journal of Experimental Medicine (1958)

The techniques of agar immunoelectrophoresis and agar double diffusion were applied to the study of the antigenicity of beta- and alpha(1)-lipoproteins separated by ultracentrifugation from normal human sera. The effects of delipidation were also investigated. It was shown that beta- and alpha(1)-lipoproteins are antigenically distinct. For each class of lipoprotein studied, a single antigenic component was demonstrated. In some, but not all, preparations of alpha(1)-lipoprotein a second, small antigenic component was detected, and identified as albumin. Absorption with lipoprotein-free serum or albumin removed this component without changing the lipoprotein band. Delipidation did not affect the antigenicity of either beta- or alpha(1)-lipoproteins. Immunoelectrophoresis, because of its high sensitivity and specificity, provides an additional criterion of purity for antigenic proteins in addition to the data that can be obtained from ultracentrifugal and free electrophoretic analysis.
Abstract 818: Chronic oxidative stress induces conversion of estrogen-dependent non-aggressive breast cancer cells into estrogen-independent aggressive phenotype
Authors: Prathap Kumar S. Mahalingaiah, Logeswari Ponnusamy, Kamaleshwar P. Singh
Journal: Cancer Research (2015)

Abstract We have recently reported increased growth and tumorigenic potential of estrogen receptor (ER) positive breast cancer cells with chronic exposure to oxidative stress. In this study, we evaluated mechanistic basis for chronic oxidative stress-induced aggressiveness in ER positive MCF-7 breast cancer cells. Loss of estrogen dependency is known to be associated with acquisition of aggressive form in breast cancer cells. Therefore, the objective of this study was to evaluate changes in estrogen response in ER-positive breast cancer cells exposed to chronic oxidative stress. MCF-7 cells were exposed to hydrogen peroxide (H2O2)-induced oxidative stress for chronic period (6 months). Using these cells, growth response to 17-β estradiol was evaluated by MTT assay and cell cycle analysis. Surprisingly, in response to 17-β estradiol treatment, there was no significant growth stimulation in cells exposed to chronic oxidative stress. Cell cycle analysis by flow cytometry further confirmed the cell growth data. Quantitative RT-PCR analysis also revealed significant down regulation of ER-α in chronically exposed breast cancer cells. To understand the role of epigenetic mechanism, the expression of epigenetic regulatory genes were determined at both transcript and protein level. In addition, the levels of histone modifications were also evaluated by Western blot analysis. Changes in both the expression of epigenetic regulatory genes (DNMT1, DNMT3b, HDAC1, MBD4, and HAT1) and the levels of histone modifications (H3K27 tri-methylation and H3K18 acetylation) were observed in MCF-7 cells chronically exposed to H2O2. Treatment with DNA de-methylating agent (5-aza-2′-deoxycytidine) restored the ER-α expression level, estrogen-induced growth and oxidative stress induced histone modifications. To summarize, the findings of this study suggest that chronic exposure to oxidative stress can convert estrogen-dependent non-aggressive breast cancer cells into estrogen-independent aggressive form potentially by epigenetic mechanism. Citation Format: Prathap Kumar S. Mahalingaiah, Logeswari Ponnusamy, Kamaleshwar P. Singh. Chronic oxidative stress induces conversion of estrogen-dependent non-aggressive breast cancer cells into estrogen-independent aggressive phenotype. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 818. doi:10.1158/1538-7445.AM2015-818