tbuckley/cabot-search huggingface dataset:
Use of Wearable Monitoring Devices to Change Health Behavior—Reply
Authors: Mitesh S. Patel, David A. Asch, Kevin G. Volpp
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Phase II Study of Targeted Subcutaneous (SC) Bortezomib for Patients with Low- or Intermediate-1 (Int-1)-Risk Myelodysplastic Syndrome (MDS) with Evidence of NF-κB Activation
Authors: Jasleen K. Randhawa, Kausar Jabeen Jabbar, Tapan Kadia, Gautam Borthakur, Naveen Pemmaraju, Naval Daver, Hagop M. Kantarjian, Jorge E. Cortes, Katherine Hearn, Carlos E. Bueso-Ramos, Guillermo Garcia-Manero
Journal: Blood (2014)
Comparitive study of quality of life in locally advanced head and neck cancers with concurrent chemoradiotherpy with three weekly cisplatin versus weekly cisplatin regimen.
Authors: Kesava Ramgopal Adavikolanu, Monica Malik, Pavankumar Lachi, Syedakram Kothwal, Deepajoseph M, Fayaz ahmed Syed, Suresh Pamidighantam, Jagannathraonaidu K.V
Journal: Journal of Clinical Oncology (2013)

e17028 Background: Concurrent chemoradiotherapy with three weekly cisplatin is the standard of care for organ preservation in locally advanced head and neck cancers. Quality of life (QoL) is vital in this strategy and this study aims to compare QoL in patients of locally advanced head and neck cancers treated with concurrent chemoradiation with either three weekly or weekly cisplatin regimen. Methods: Between January 2011 and May 2012, 30 patients of locally advanced head and neck cancer were divided into two arms each consisting of 15 patients. All patients received conformal radiotherapy (RT) on linear accelerator to a total dose of 70 Gy, 2 Gy per fraction over 35 fractions. Patients in Arm A received concurrent chemotherapy with Cisplatin 100mg/m 2 given on day1,22,43. Patients in Arm B received concurrent chemotherapy with Cisplatin 40 mg/m 2 given weekly for seven weeks. QoL was assessed using EORTC QLQ-C30 and QLQ-H&amp;N35 questionnaires at baseline, completion of RT and at one and two months following completion of treatment. The collected data was analyzed using standard statistical software package (SPSS version 20.0). Results: Median age in Arm A and Arm B were 45 years (range 23-67years) and 48 years (range 36-71) respectively. All patients completed the planned RT, 73% of patients in Arm A and 93% of patients in Arm B received the planned dose of chemotherapy. Compliance with completion of QoL questionnaires was high in both arms. QoL scores decreased during chemoradiotherapy in both arms, and the scores were better in Arm B without statistical significance. The QoL scores reached baseline earlier in the Arm B compared to Arm A for most of the function scales and symptom scales at second month follow up. There was no statistical difference between the two arms for most of the parameters, except for symptom scales of pain (p=0.029) at 1 st month follow-up and swallowing (p=0.023) at 2 nd month follow-up favouring Arm B. Conclusions: Chemoradiotherapy with weekly cisplatin 40mg/m 2 with its better compliance and favourable quality of life can serve as an alternative for the conventional three weekly cisplatin regimen.
Methylphenidate for Attention-Deficit/Hyperactivity Disorder
Authors: Marcel Romanos, Andreas Reif, Tobias Banaschewski
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
68Ga-PSMA Uptake in Hepatocellular Carcinoma
Authors: Sangeeta Taneja, Rajesh Taneja, Vikas Kashyap, Abhishek Jha, Amarnath Jena
Journal: Clinical Nuclear Medicine (2016)

Ga-PSMA based integrated PET/MRI is emerging as a novel imaging technique for the staging of prostate carcinoma. We report a case of a 77-year-old man with raised prostate-specific antigen who presented to us for Glu-NH-CO-NH-Lys-(Ahx)-[Ga-(HBED-CC)] (Ga-PSMA) simultaneous PET/MRI scan for prostate cancer evaluation. A PSMA avid hepatic lesion on the background of cirrhotic liver was noted apart from PSMA avid lesion in the peripheral gland of the prostate. On histopathological examination, the hepatic lesion turned out to be hepatocellular carcinoma.
Response by Lai and Gladwin to Letter Regarding Article, “SIRT3-AMP–Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction”
Authors: Yen-Chun Lai, Mark T. Gladwin
Journal: Circulation (2016)
Male Gender, Quality of Grafted Cells, Advanced Age, Rituximab and Radiotherapy Are the Main Factors That Variously Influence the Occurrence of Secondary Malignancies Following High-Dose Therapy and Autograft: A GITIL (Gruppo Italiano Terapie Innovative nei Linfomi) Survey in 1,347 Lymphoma Patients.
Authors: Corrado Tarella, Roberto Passera, Michele Magni, Andrea Rossi, Fabio Benedetti, Angela Gueli, Caterina Patti, Guido Parvis, Fabio Ciceri, Andrea Gallamini, Sergio Cortelazzo, Paolo Corradini, Valerio Zoli, Antonio Mule', Roberto Crocchiolo, Marco Bosa, Anna Barbui, Massimo Di Nicola, Daniele Caracciolo, Marco Sorio, Alessandro M. Gianni, Alessandro Rambaldi
Journal: Blood (2009)
P92 Predictive factors for early cardiac events following liver transplantation
Authors: J Leithead, K Kandiah, R Steeds, J W Ferguson
Journal: Gut (2010)

Introduction  Coronary artery disease (CAD) is associated with increased short-term morbidity and mortality following liver transplantation. As a result, the AASLD recommends that all high risk individuals should undergo CAD evaluation during transplant assessment. The AASLD defines high risk as age over 50 years, a clinical or family history of cardiac disease, known diabetes or a positive smoking history. However, whether such traditional risk factors for CAD are associated with an increased risk of post operative cardiac events in this setting remains unclear.  Aim  To determine if the AASLD criteria for CAD evaluation identify patients at risk of an early CE post liver transplant.  Method  Retrospective study of 252 consecutive patients who were assessed and subsequently underwent elective liver transplantation 01/2007–03/2010. Variables were recorded at time of transplant assessment. A CE was defined as myocardial infarction, cardiac arrest, cardiogenic pulmonary oedema or complete heart block (Lee  et al  1999) by 90-days post transplant. ROC analysis was used to determine appropriate cut-off values.  Results  10 patients had a CE during the specified time period following transplantation. The CE patients were older (age, 59.3 vs 52.9 yrs, p=0.046) than the non CE patients but had similar gender (M:F, 2.3:1 vs 1.9:1, p=0.529) and ethnicity (white:asian:other, 7.6:1:0.3 vs 4:1:0, p=0.605). 216 patients (86.4%) fulfilled the AASLD criteria for CAD evaluation. The CE rate was 5.7% and 0% in patients who did and did not fulfil the criteria, respectively (p=0.225). When considered individually, known cardiac disease (CE 30.0%, non-CE 4.9%, p=0.017), but not smoking (CE 70.0%, non-CE 56.9%, p=0.317), age >50 yrs (CE 90.0%, non-CE 68.8%, p=0.140) or diabetes (CE 40.0%, non-CE 26.8%, p=0.230), was predictive of a CE. The variables that were associated with post transplant CE were age=57 yrs (p=0.010), hypertension (p=0.067), BMI=30 (p=0.052), hyponatraemia (p=0.005), diuretic therapy (p=0.001), MELD=16 (p=0.058) and UKELD=54 (p=0.002). On multivariate analysis, the variables associated with a CE were known cardiac disease (OR 11.1; 95%CI 1.5 to 85.3, p=0.020), age=57 yrs (7.5; 95%CI 1.3 to 42.0, p=0.022), hypertension (OR 4.5; 95%CI 0.9 to 23.0, p=0.072) and UKELD=54 (OR 33.4; 95% CI 3.8 to 291.8, p=0.002). The presence of =2 of these variables predicted a CE with a sensitivity of 90.0%, specificity of 82.7% and NPV of 99.4%.  Conclusion  The AASLD criteria for CAD evaluation do not identify patients at risk of an early CE following liver transplantation. Alternative variables may be more appropriate for stratifying patients into low and high risk groups.
Health secretary promises “world class” hospital IT
Authors: Matthew Limb
Journal: BMJ (2016)

England’s health secretary, Jeremy Hunt, has pledged to improve and extend the NHS’s digital services, bolstered by a new staff skills academy and a so called “Ivy League” of exemplar trusts.

He said that digital technologies could improve the quality of care and safety of patients and that the NHS needed a “new generation” of skilled clinical information specialists to ensure “world class” information technology in hospitals.

Hunt said, “IT transformations fail if they don’t have clinical leadership. We have to make sure every penny we spend improves doctor productivity, because then we’ll get doctor buy-in and nurse buy-in to these changes.”

He was speaking on Wednesday 7 September at NHS England’s Expo 2016 in Manchester, where he …
MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells
Authors: Shogo Kuwagata, Shinji Kume, Masami Chin-Kanasaki, Hisazumi Araki, Shinichi Araki, Jun Nakazawa, Takeshi Sugaya, Daisuke Koya, Masakazu Haneda, Hiroshi Maegawa, Takashi Uzu
Journal: Kidney International (2016)
Transferrin Receptor 2 and HFE Regulate Hepcidin Levels Independently of Bmp6 and Hemojuvelin
Authors: Céline Besson-Fournier, Chloé Latour, Ophélie Gourbeyre, Patricia Aguilar-Martinez, Laura Silvestri, Marie-Paule Roth, Hélène Coppin
Journal: Blood (2014)
Cases in Bioethics From the Hastings Center Report
Authors: Mark E. Battista
Journal: JAMA (1983)

Your patient's first trimester exposure to a drug associated with a fourfold increase in the incidence of cleft palate leads her to request an abortion, although the actual risk is very small and the condition can be corrected. Another patient has just announced her engagement to a man you have certified as homosexual for draft exemption purposes, and you are quite sure she isn't aware of his sexual preference. A "premed" student preparing for the MCAT approaches you with some persuasive arguments that the small doses of amphetamines he is asking for, to enhance his examination performance, won't hurt him or you. There is the patient whose motor vehicle accident, you are almost certain, was self-inflicted. Now he needs lifesaving surgery but calmly and apparently rationally refuses to consent. Or, as a resident you may be torn by your awareness that your program's unusually tough work schedule is hurting both
Heinrich Koebner and His Phenomenon
Authors: Marco Diani, Chiara Cozzi, Gianfranco Altomare
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Abstract P115: Cardiorespiratory Fitness Level is Associated with Metabolic Risk in an Asymptomatic Population
Authors: Ebenezer T Oni, Michael J Blaha, Seth S Martin, Arthur S Agatston, Roger S Blumenthal, Jose A Carvalho, Raquel D Conceiçao, Romeu S Meneghelo, Raul D Santos, Khurram Nasir
Journal: Circulation (2016)

Background: Cardiorespiratory fitness (CRF) is a measure of habitual physical activity level of an individual. We evaluate the association between CRF and measures of metabolic risk: Fatty Liver Index (FLI) and Lipid Accumulation Product (LAP). Methods: This study evaluated 3,154 asymptomatic Brazilian subjects (43±10 years, 80% males) who had metabolic equivalent (METS) measured during routine health screen between November 2008 and July 2010. Both FLI and LAP were calculated from standardized algorithms. Results: The prevalence of METS attained were classified into 3; category 1: METS ≤ 12 (44%, n=1,377), category 2 METS &gt;12 &amp; &lt;14 (33%, n=1050) and category 3: METS ≥ 14 (23%, n=727). There was a steady decrease in both median FLI and LAP with higher CRF categories, Figure 1. A logistic regression analysis showed that higher fitness level was associated with lower LAP and FLI levels, see table 1. Conclusions: Higher CRF level is associated with reduced cardiometabolic risk among asymptomatic individuals. This re-emphasis the importance of promoting increasing fitness level to improve health.
Prospective Study of Oral Health and Risk of Primary Open-Angle Glaucoma in Men
Authors: Louis R. Pasquale, Leslie Hyman, Janey L. Wiggs, Bernard A. Rosner, Kaumudi Joshipura, Mark McEvoy, Zachary E. McPherson, John Danias, Jae H. Kang
Journal: Ophthalmology (2016)
Transferability Of Results From Randomized Trials To Clinical Practice: The Case Of Diffuse Large B Cell Lymphoma Patients Treated With R-CHOP When Comorbidities Are Present
Authors: Andrea Rossi, Giuseppe Gritti, Ariel Amaru Calzada, Cristina Boschini, Federica Delaini, BiolSc, Alessandro Rambaldi
Journal: Blood (2013)
A20 inhibition of STAT1 expression in myeloid cells: a novel endogenous regulatory mechanism preventing development of enthesitis
Authors: Katelijne De Wilde, Arne Martens, Stijn Lambrecht, Peggy Jacques, Michael B Drennan, Karlijn Debusschere, Srinath Govindarajan, Julie Coudenys, Eveline Verheugen, Fien Windels, Leen Catrysse, Rik Lories, Dennis McGonagle, Rudi Beyaert, Geert van Loo, Dirk Elewaut
Journal: Annals of the Rheumatic Diseases (2016)

A20 is an important endogenous regulator of inflammation. Single nucleotide polymorphisms in A20 have been associated with various immune-mediated inflammatory diseases, and cell-specific deletion of A20 results in diverse inflammatory phenotypes. Our goal was to delineate the underlying mechanisms of joint inflammation in myeloid-specific A20-deficient mice (A20myelKO mice).Inflammation in A20myelKO mice was assessed in a time-dependent manner. Western blot analysis and quantitative PCR analysis were performed on bone marrow-derived macrophages from A20myelKO and littermate control mice to study the effect of A20 on STAT1/STAT3 expression and STAT1/STAT3-dependent gene transcription in myeloid cells. The in vivo role of Janus kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling in the development of enthesitis in A20myelKO mice was assessed following administration of a JAK inhibitor versus placebo control.Enthesitis was found to be an early inflammatory lesion in A20myelKO mice. A20 negatively modulated STAT1-dependent, but generally not STAT3-dependent gene transcription in myeloid cells by suppressing STAT1 but not STAT3 expression, both in unstimulated conditions and after interferon-γ or interleukin-6 stimulation. The increase in STAT1 gene transcription in the absence of A20 was shown to be JAK-STAT-dependent. Moreover, JAK inhibition in vivo resulted in significant reduction of enthesitis, both clinically and histopathologically.Our data reveal an important and novel interplay between myeloid cells and tissue resident cells at entheseal sites that is regulated by A20. In the absence of A20, STAT1 but not STAT3 expression is enhanced leading to STAT1-dependent inflammation. Therefore, A20 acts as a novel endogenous regulator of STAT1 that prevents onset of enthesitis.
ABVD chemotherapy with interferon for advanced-stage classical Hodgkin's lymphoma: A 10-year follow-up study.
Authors: N. Batty, F. B. Hagemeister, J. E. Romaguera, M. A. Rodriguez, P. McLaughlin, F. Samaniego, A. Copeland, B. S. Dabaja, A. Younes
Journal: Journal of Clinical Oncology (2010)

8057 Background: Adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy has been the standard of care for Hodgkin's lymphoma (HL) for almost three decades. Previous studies demonstrated clinical benefit by combining interferon-alpha (IFN-α) with chemotherapy in newly diagnosed patients (pts) with follicular lymphoma (Sola-Celigny, N Eng J Med. 1993). In this study, we examined the safety and efficacy of the novel IFN-α and ABVD regimen in pts with advanced stage classical HL. Methods: Pts with newly diagnosed advanced stage classical HL were enrolled between July 1997 and March 2000 on Phase II trial of IFN-α + ABVD as initial therapy. The regimen consisted of 6 cycles of ABVD with concurrent IFN-α followed by XRT if indicated. The IFN-α was 6 million IU/ m2 administered subcutaneously on daily schedule for 3 days prior to starting chemotherapy and on day 4 the pts received IFN-α with ABVD. The courses were repeated every 2 weeks for a maximum of 12 doses. IFN-α, dose reduction was allowed for cytopenias. Outcome and baseline characteristics were reported. Results: Twenty eight newly diagnosed pts were eligible: Ann Arbor stages of II, III, IV, were 2 (7%), 9 (32%), and 17 (61%), respectively; International prognostic score (IPS) of 0-2 and ≥ 3 were 15 (54%) and 13 (46%), respectively. Fourteen pts (50%) underwent XRT. With a median follow-up of 10 years, the three-year event-free (EFS) and overall survival was 80% and 100%, respectively. The EFS at three years for pts with IPS of 0-2 and ≥ 3 were 78.5 % and 82.5%, respectively. The treatment was well tolerated with only three pts requiring dose reduction or discontinuation of IFN-α due to cytopenia. Conclusions: IFN-α + ABVD is well tolerated and has promising clinical activity, especially in pts with high IPS. Further development of this regimen is warranted. No significant financial relationships to disclose.
Multiple Polyploidization Events across Asteraceae with Two Nested Events in the Early History Revealed by Nuclear Phylogenomics
Authors: Chien-Hsun Huang, Caifei Zhang, Mian Liu, Yi Hu, Tiangang Gao, Ji Qi, Hong Ma
Journal: Molecular Biology and Evolution (2016)

Biodiversity results from multiple evolutionary mechanisms, including genetic variation and natural selection. Whole-genome duplications (WGDs), or polyploidizations, provide opportunities for large-scale genetic modifications. Many evolutionarily successful lineages, including angiosperms and vertebrates, are ancient polyploids, suggesting that WGDs are a driving force in evolution. However, this hypothesis is challenged by the observed lower speciation and higher extinction rates of recently formed polyploids than diploids. Asteraceae includes about 10% of angiosperm species, is thus undoubtedly one of the most successful lineages and paleopolyploidization was suggested early in this family using a small number of datasets. Here, we used genes from 64 new transcriptome datasets and others to reconstruct a robust Asteraceae phylogeny, covering 73 species from 18 tribes in six subfamilies. We estimated their divergence times and further identified multiple potential ancient WGDs within several tribes and shared by the Heliantheae alliance, core Asteraceae (Asteroideae–Mutisioideae), and also with the sister family Calyceraceae. For two of the WGD events, there were subsequent great increases in biodiversity; the older one proceeded the divergence of at least 10 subfamilies within 10 My, with great variation in morphology and physiology, whereas the other was followed by extremely high species richness in the Heliantheae alliance clade. Our results provide different evidence for several WGDs in Asteraceae and reveal distinct association among WGD events, dramatic changes in environment and species radiations, providing a possible scenario for polyploids to overcome the disadvantages of WGDs and to evolve into lineages with high biodiversity.
Highlights of the Year in JACC 2007
Authors: Anthony N. DeMaria, Jeroen J. Bax, Ori Ben-Yehuda, Paul Clopton, Gregory K. Feld, Geoffrey S. Ginsburg, Barry H. Greenberg, James D. Knoke, Wilbur Y.W. Lew, João A.C. Lima, Alan S. Maisel, Sanjiv M. Narayan, Jagat Narula, David J. Sahn, Sotirios Tsimikas
Journal: Journal of the American College of Cardiology (2008)
Computerized Physician Order Entry Systems and Medication Errors
Authors: A. Keillor
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal