tbuckley/cabot-search huggingface dataset:
Letters to the Editor
Authors: F. E. SHIDEMAN
Journal: Circulation Research (1974)

Responsiveness of the 4-Day-Old EmbryonicChick Heart to Catecholamines In a recent paper (Circ Res 31:932-952, 1972) Shigenobu and Sperelakis reported that they were unable to demonstrate a significant effect of either epinephrine or isoproterenol in concentrations as high as 1 X 10~5M on electrical or mechanical activity of driven ventricular muscle from young chick embryos (3-5 days old).Similarly, Hollman and Green (Fed Proc 32:711 [abstr.],1973) could not obtain a positive inotropic response to isoproterenol from the electrically driven (Green, personal communication) myocardium of 4-day-old chick embryo.On the other hand, McCarty et al. (J Pharmacol Exp Ther 129:315-321, 1960) showed that epinephrine at a concentration as low as 5.47 X 10~1 0 M exerts both positive inotropic and chronotropic effects in the isolated, spontaneously beating 4-day-old embryonic chick heart.Because of my interest in using the 4-day-old embryonic chick heart as a model to study certain characteristics of the adrenergic receptor, it was necessary for me to establish beyond reasonable doubt that such receptors exist and are functional at this stage of development.Accordingly, I have used isolated, spontaneously beating hearts from embryos of this age and determined their responsiveness to the four catecholamines, lisoproterenol, /-epinephrine, /-norepinephrine, and dopamine.The method originally described by Mc-Carty et al. (
QOS-26HEALTH-RELATED QUALITY OF LIFE (HRQOL) IN HIT-SIOP-PNET4 TRIAL SURVIVORS: DIFFERENCES BETWEEN MEDULLOBLASTOMA MOLECULAR SUBGROUPS
Authors: Kim Bull, Colin Kennedy, Ed Schwalbe, Debbie Hicks, Francois Doz, Stefan Rutkowski, Birgitta Lannering, Torsten Pietsch, Steven Clifford
Journal: Neuro-Oncology (2016)
Solving the Problem of Video Recording Gaps in Capsule Endoscopy of Overweight Patients
Authors: U.  Seitz, N.  Soehendra
Journal: Endoscopy (2003)

Capsule endoscopy [1] is a novel tool for visualizing the small intestine. A passively transported capsule (M2A capsule, Given Imaging, Yoqneam, Israel) transmits two images per second to a sensor array taped onto the patient’s abdomen. A small portable recorder collects more than 50 000 images, which are downloaded to a computer and then evaluated. Unfortunately, transmission gaps sometimes are observed.
Tentonin 3/TMEM150c Confers Distinct Mechanosensitive Currents in Dorsal-Root Ganglion Neurons with Proprioceptive Function
Authors: Gyu-Sang Hong, Byeongjun Lee, Jungwon Wee, Hyeyeon Chun, Hyungsup Kim, Jooyoung Jung, Joo Young Cha, Tae-Ryong Riew, Gyu Hyun Kim, In-Beom Kim, Uhtaek Oh
Journal: Neuron (2016)
Caractéristiques anatomopathologiques, endoscopiques et moléculaires de la “jupe” – une nouvelle entité lésionnelle des berges de tumeurs à extension latérale
Journal: Endoscopy (2016)

Les tumeurs à extension latérale (les fameuses “laterally spreading tumors” ou LST selon les anglo-saxons) sont des lésions pré-cancéreuses coliques le plus souvent localisées dans le rectum, qui peuvent être classées en LST granulaires, non-granulaires (= lisses) ou mixtes. De mieux en mieux connues, elles sont considérées comme un précurseur du cancer colorectal et pourraient dégénérer selon une voie de carcinogénèse particulière.
Behavioral therapy for urinary incontinence
Authors: Cheryl B Iglesia
Journal: JAMA (1989)

<h3>In Reply. —</h3> The nursing research assistants employed in follow-up did not know the patients' assignments (treatment or control) to avoid potential datacollection bias. There are several possible explanations for the durability of the training effect. First, the study may have had a carryover effect on the homes' regular nursing aides, who may have been more responsive even during follow-up because a research study was being conducted. Second, encouraging patients to hold their urine (a study objective) may have helped physiologically to reduce incontinence, especially among the 34% more cognitively alert treatment participants (Mini-Mental State Examination score, &gt;17). Last, the reinstatement of hourly checking during follow-up may have created a "checking effect" that reminded patients they needed to toilet. However, any checking effect should have affected both the experimental and the control groups. Since the experimental group consistently improved more than the control group, we are inclined to give more
"MEDICAL CARE FOR THE AMERICAN PEOPLE"
Authors: L H BAUER
Journal: Annals of Internal Medicine (1933)

We are concerned with a problem on which there are sharp differences of opinion. In fact, were there not these differences of opinion there would be no problem.  As to the ultimate aim we are all agreed. I believe no one can quarrel with the platform of the American Medical Association, adopted in June 1944, which calls for availability of medical care of a high quality to every person in the United States, The differences of opinion arise as to how this aim is to be achieved.  As doctors we see the problem in a way no one else can possibly see it. It pertains to our daily work and we are naturally closer to it than any one else. One does not consult a doctor if one wishes to draw up a will. One goes to a lawyer. Neither does one
Results of the Prospective Evaluation of Radial Keratotomy (PERK) Study Five Years after Surgery
Authors: George O. Waring, Michael J. Lynn, Azhar Nizam, Michael H. Kutner, John W. Cowden, William Culbertson, Peter R. Laibson, Marguerite B. McDonald, J. Daniel Nelson, Stephen A. Obstbaum, J. James Rowsey, James J. Salz, Linda B. Bourque
Journal: Ophthalmology (1991)
Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo
Authors: Ewa M. Kosciuczuk, Diana Saleiro, Barbara Kroczynska, Elspeth M. Beauchamp, Frank Eckerdt, Gavin T. Blyth, Sameem M. Abedin, Francis J. Giles, Jessica K. Altman, Leonidas C. Platanias
Journal: Blood (2016)
Diagnosis of Latent Tuberculosis Infection in HIV-infected Pregnant Women. “Baby Steps” toward Better Tuberculosis Control in Pregnancy
Authors: Dominik Zenner, David Ashkin
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Despite significant reductions in incidence, the global burden of tuberculosis (TB) is immense. In 2014, there were an estimated 9.6 million new cases, accounting for 1.1 million deaths, with an estimated 1.2 million (12.5%) of these new cases being in patients infected with HIV. Although TB is more common among men, globally TB is a leading cause of death among women of childbearing age. The higher risk for TB during pregnancy, as well as adverse outcomes for mother and child, have been previously recognized (2–5) and are potentially related to the physiological partial inhibition of the cellular immune system necessary to tolerate the fetus.
Osteoporosis in Men
Authors: Willem F Lems, Piet P M M Geusens
Journal: New England Journal of Medicine (2008)

Traditionally, osteoporosis has been predominantly studied in women; nevertheless, men are not protected from bone loss and its complications. Remarkably, mortality after osteoporotic fractures is higher in men compared to women. In men, both estrogens and androgens play an important role in the regulation of bone turnover. Pathophysiological specificities of osteoporosis in men are osteoblastic deficiency and a high frequency of secondary causes of osteoporosis. Several randomized control trials specifically investigated the treatment of osteoporosis in men and demonstrated a reduction of vertebral fracture incidence.
Sex differences in recurrent depression: are there any that are significant?
Authors: E Frank, L L Carpenter, D J Kupfer
Journal: American Journal of Psychiatry (1988)

The authors report on sex differences in a group of 230 patients with recurrent depression. Male and female patients were similar in clinical characteristics and baseline measures of severity. Some sex differences in depressive symptoms were apparent, especially as reflected by self-report instruments. The women reported more appetite and weight increase, more somatization, and expressed anger and hostility. The men demonstrated a more rapid response to treatment. Various interpretations of these findings are discussed.
ASCO--as a young adult.
Authors: J R Durant
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.9.1431 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3528406 ASCO--as a young adult. J R DurantxJ R DurantSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.9.1431 First Page PDF © 1986 by American Society of Clinical Oncology
MB-22ACTIVATED Wnt SIGNALING FOR THE THERAPEUTIC TARGETING OF TREATMENT-REFRACTORY MEDULLOBLASTOMA STEM CELLS
Authors: Branavan Manoranjan, Sujeivan Mahendram, David Bakhshinyan, Michelle Kameda-Smith, Chitra Venugopal, Bradley Doble, Sheila Singh
Journal: Neuro-Oncology (2016)
Exploring Coping Strategies for Patients With Hidradenitis Suppurativa
Authors: Joslyn S. Kirby, Mia Sisic, Jerry Tan
Journal: JAMA Dermatology (2016)

and stage 3 (9 [42.9%]) disease.Nearly all the participants (n = 18, 85.7%) commented on their own coping strategies, including physical and social coping.Half of the participants (n = 10, 47.6%) reported on the role of social support from friends, family, strangers, etc.The Box provides examples of some direct quotes about coping strategies used by participants that demonstrate the data supporting these findings.Discussion | In this study, patients with HS used several coping and social support strategies.Studies of patients with psoriasis show patients' QOL is related to coping style.For example, those with an emotive coping style (eg, daydreaming about a different life) had lower QOL.In contrast, those with higher perceived social support or a normalizing style of coping, which includes informing others about their condition, had a higher QOL. 5 For nondermatologic conditions, changes in coping style are correlated with improved QOL and functional outcomes for patients with musculoskeletal injuries. 6his is an exploratory qualitative study of limited size, but it may have an effect on practice in 2 ways.First, this research expands on earlier studies to demonstrate the presence of multiple coping styles and social support strategies for patients with HS.Second, this research highlights patients' physical and social coping skills as well as the importance of having social support from others (friends, family, and others).Future research could study the coping strategies used by patients with HS, the impact of teaching those coping strategies to patients with less positive styles, and the subsequent impact on QOL and HS severity.
リポ蛋白(a)の血清レベルに対するアスピリン治療の影響:アポリポ蛋白質(a)アイソフォームの分析
Authors: Akaike M, Azuma H, Matsumoto K, Hayashi I, Tamura K, Nishiuchi T, Kagawa A, Kanagawa Y, Aihara K, Matsuyama M, Takamori N, Matsumoto T
Journal: Circulation (1999)
Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites
Authors: You Zhou, Matej Orešič, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia Hyötyläinen, Hannele Yki-Järvinen
Journal: Clinical Gastroenterology and Hepatology (2016)
PNR-39DISTINCT GENE FUSIONS SEGREGATE SUB-CLASSES OF CNS-PNETs
Authors: Joseph Norman, Jonathon Torchia, Nicolas De Jay, Daniel Picard, Patricia Rakopoulos, Dariusz Adamek, Daniel Catchpoole, Steven Clifford, Xing Fan, Jason Fangusaro, Fabien Forest, Maryam Fouladi, Amar Garjjar, Yancey Gillespie, Jordan Hansford, James Hayden, Lindsay Hoffman, Suradej Hongeng, Chris Jones, Anne Jouvet, Audrey Kaorshunov, Ching Lau, Suzanne Miller, Karin Muraszko, Ho-keung Ng, Stefan Pfister, Joanna Phillips, Scott Pomeroy, Alyssa Reddy, Hazel Rogers, Helen Toledano, Timorthy Van Meter, Yin Wang, Cheng Ying Ho, Ra Young-Shin, Michael Taylor, Diane Birks, Cynthia Hawkins, Eric Bouffet, Richard Grundy, Nada Jabado, Claudia Kleinman, Annie Huang
Journal: Neuro-Oncology (2016)
Brief Report: Atypical Femoral Fracture in Rheumatoid Arthritis Patients Treated With Bisphosphonates: A Nested Case–Control Study
Authors: Jung Hee Koh, Jun Pyo Myong, Seung Min Jung, Jennifer Lee, Seung‐Ki Kwok, Sung‐Hwan Park, Ji Hyeon Ju
Journal: Arthritis & Rheumatology (2015)

To examine the clinical characteristics of atypical femoral fracture (AFF) and to determine the risk factors for and clinical outcomes of AFFs in rheumatoid arthritis (RA) patients treated with bisphosphonates (BPs).A nested case-control study was conducted using data derived from the medical records of all RA patients treated with BPs at Seoul St. Mary's Hospital, a tertiary rheumatology center, from January 1, 2008 to December 31, 2014. All of the patients with RA and had been treated with BPs for at least 1 year. Ten RA patients with AFF were identified, and each of these patients (cases) was age- and sex-matched with 4 RA patients without AFF (controls).Five hundred fifty-two RA patients had BP exposure. Of the 10 with AFF, all were female (mean ± SD age 66.3 ± 8.7 years), and 90% of cases involved fracture of the proximal femur. The mean ± SD length of BP exposure in patients with AFF was 7.4 ± 3.2 years. Compared with controls, patients with AFF had a longer exposure to BPs and more often had a femorotibial angle of <175 degrees (both P < 0.001). There were no differences in RA duration, medications taken during the previous 6 months, and bone mineral density in the femur and lumbar spine between patients with and those without AFF. Multivariate logistic analyses identified longer BP exposure (odds ratio 2.386 [95% confidence interval 1.066-5.343]) as being associated with an increased risk of AFF.RA patients who have a valgus deformity and are receiving long-term BP treatment are at higher risk of AFF compared with matched control patients with RA. These patients should be carefully followed up with hip radiography or dual x-ray absorptiometry.
Italy’s new vaccination schedule reduced coverage of poliomyelitis vaccine in Naples
Authors: M. G. Panico, N M Trinchese, B Serpieri, F Attena
Journal: Eurosurveillance (2000)

Italy s health ministry introduced changes to the immunisation schedules for children on 7 April 1999, including immunisation against poliomyelitis. The changes included the replacement of the first two childhood doses of oral poliomyelitis vaccine (OPV)
The Federal Cancer Control Program
Authors: Carl Voegtlin, R.R. Spencer
Journal: JNCI Journal of the National Cancer Institute (1940)

The Federal Cancer Control Program Get access Carl Voegtlin, Carl Voegtlin Chief National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar R.R. Spencer R.R. Spencer Assistant Chief National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 1, 1940-1941, Pages 1–9, https://doi.org/10.1093/jnci/1.1.1 Published: 01 August 1940
Respiration Disorders in Panic Attacks
Authors: D F Klein
Journal: JAMA (1995)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Anti-tumor Efficiency of Lipid-coated Cisplatin Nanoparticles Co-loaded with MicroRNA-375
Authors: Tan Yang, Pengxuan Zhao, Zhao Rong, Bin Li, Huiying Xue, Jia You, Chuanchuan He, Weijie Li, Xingxing He, Robert J. Lee, Xiang Ma, Guangya Xiang
Journal: Theranostics (2015)

One of the major challenges in the hepatocellular carcinoma (HCC) treatment is its insensitivity to chemotherapeutic drugs.Here, we report the development of novel lipid-coated cisplatin nanoparticles co-loaded with microRNA-375 (NPC/miR-375) as a potential treatment for chemotherapy insensitive HCC.The NPC/miR-375 was fabricated by mixing two reverse microemulsions containing KCl solution and a highly soluble cis-diaminedihydroplatinum (II) coated with a cationic lipid layer.Subsequently, the miR-375 was incorporated into the lipid-coated cisplatin nanoparticles.The NPC/miR375 nanoparticles were expected to further decrease cell proliferation and to enhance the anti-tumor effect of cisplatin in chemotherapy resistant HCC cells.In vitro analysis of intracellular trafficking revealed that NPC/miR-375 were able to escape from the late endosomes instead of lysosomes thus avoiding degradation of the miR-375 in lysosomes.Importantly, NPC/miR-375 enhanced apoptosis and induced cell cycle arrest in HCC cells in vitro.In the double oncogenes Akt/Ras-induced primary HCC mouse model, multiple doses of NPC/miR-375 significantly inhibited tumor growth and delayed the tumor relapse.Our results indicate that cisplatin nanoparticles co-loaded with miR-375 represent a potential therapeutic agent for chemotherapy-insensitive HCC.
LG-71MALIGNANT TRANSFORMATION OF A PEDIATRIC SPINAL CORD LOW-GRADE GLIONEURONAL TUMOR WITH BRAF DUPLICATION: A CASE REPORT
Authors: Ana Aguilar-Bonilla, Emily Owens Pickle, Rachel Gray, Amy Smith
Journal: Neuro-Oncology (2016)

LG-71. MALIGNANT TRANSFORMATION OF A PEDIATRIC SPINAL CORD LOW-GRADE GLIONEURONAL TUMOR WITH BRAF DUPLICATION: A CASE REPORT Ana Aguilar-Bonilla, Emily Owens Pickle, Rachel Gray, and Amy Smith; Arnold Palmer Hospital for Children, Orlando, FL, USA Pediatric low-grade glioma is the most common type brain tumor diagnosed in childhood. Low-grade tumors generally have a good prognosis and rarely undergo malignant transformation. We present the case of a patient with a low-grade glioneuronal tumor of the spinal cord with BRAF duplication that transformed into a high-grade poorly differentiated tumor 20 months after diagnosis. Recent studies have identified BRAF alterations in low-grade gliomas; two commonly described aberrations are KIAA1549-BRAF fusion and BRAFV600E mutation. BRAF fusion is more commonly seen in pilocytic astrocytomas and BRAF mutations in pleomorphic xanthoastrocytomas. Our patient was a 14 year old female with a spinal cord tumor that extended from C3-C4 to the conus medullaris. An aggressive sub-total resection was performed with residual tumor observed in the thoracic cord and conus medullaris. Pathology wasconsistentwith a low-grade tumor buthad local progression after an initial 3 month observation period. She received chemotherapy with Carboplatin and Vincristine. Fifteen months into treatment, imaging revealed disseminated leptomeningeal spread throughout the CNS. Repeat tumor biopsy was consistent with a high-grade tumor. Her tumor progressed rapidly despite chemotherapy and radiation. She developed abdominal seeding of her tumor and died of disease 22 months after initial diagnosis. Although it is still early to know the significance of these mutations, several studies have shown that BRAF fusion positive tumors have better outcome. Here we present an unusual case of a patient with BRAF fusion + low grade glioneuronal tumor with rapid progression into a highly malignant tumor with peritoneal dissemination. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.71 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Morphologic Changes in Salivary-Gland Tissue of the Newborn Mouse Exposed to Parotid-Tumor Agent &lt;italic&gt;In Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Clyde J. Dawe, Lloyd W. Law
Journal: JNCI Journal of the National Cancer Institute (1959)

Salivary-gland tissue of newborn C3Hf/BiLw mice was excised and exposed to parotid-tumor agent (polyoma virus) before transferral to tissue cultures. The cultures were examined microscopically at intervals from 5 to 48 days after explantation. Control cultures were prepared and examined in the same way, without exposure to the agent. In both the test and control cultures at 5 and 12 days there was atrophy and necrosis within the explants with no significant difference between the exposed and unexposed tissues. From the 19th day onward, differences between the exposed and unexposed cultures were consistently evident. Salivary-gland epithelium in the test cultures developed characteristics very similar to those of salivary tumor cells in vivo. There was active proliferation with filling of the glandular lumens by altered cells. Solid cords of cells extended from the glands and reproduced the patterns of the analogous tumors in vivo. The mitotic index was higher in the test cultures than in the controls. Cytologic changes characteristic of salivary tumors in vivo also were noted in the exposed cultures. Nuclei were enlarged, nucleoli more prominent, and intranuclear, clear spaces were often present, sometimes surrounding a large, amphophilic body. The cytolytic effect of the agent was apparent in vitro as in vivo. It is concluded that the parotid-tumor agent acts on the salivary-gland epithelium, without intermediation of other organs, to produce morphologic changes similar to those seen in vivo.
NS-24CURRENT TREATMENT APPROACHES FOR INFANTS WITH BRAIN TUMORS AND LONG-TERM OUTCOMES
Authors: Kaspot Matuev, Sergey Gorelyshev, Andrey Lubnin
Journal: Neuro-Oncology (2016)

NS-24. CURRENT TREATMENT APPROACHES FOR INFANTS WITH BRAIN TUMORS AND LONG-TERM OUTCOMES Kaspot Matuev1,2, Sergey Gorelyshev1,2, and Andrey Lubnin1; Burdenko Neurosurgical Institute, Moscow, Russia; Russian Medical Academy of Postgraduate Education, Moscow, Russia The long-termresults strictlydependon radicalityof tumor removalandhistology of the tumor. Most of brain tumors in infants shoud be radically removed. We aimed to analyse of the long-term results of comprehensive treatment of brain tumors in infants, according to radicality of surgery, tumor location and degree of malignancy. We analised the long-term results in 80 infants (1 to 12 months) with brain tumors, that were operated on from 2000 to 2010 in the Burdenko Neurosurgical Institute, Moscow, Russia. Total removal was achieved in 85% cases of the lateral and third ventricle tumors; tumors of large hemispheres 82%; posterior fossa tumors 83%. Total removal in cases of chiasmatic region tumors was possible in the minority of patients 15%. Five-year overall survival rates depended on the malignancy of tumor: GrI-II 92%, GrIII-IV 48%. The best long-term outcomes were obtained after total removal of astrocytomas GrI, GrIII and plexus papilloma. Total removal malignant gliomas, plexus carcinoma, ependymoma increases the efficiency of adjuvant therapy and progression free survival.