tbuckley/cabot-search huggingface dataset:
Abstract 3990: The role of Th17 cells in the microenvironment of oral squamous cell carcinoma.
Authors: Rongfa Bu
Journal: Cancer Research (2013)

Abstract Objective: To find out if there is any abnormal in the Th17 level of OSCC patients in vivo, to affirm their inhibitory effects on OSCC and find relative mechanism.To find new way to control OSCC though Th-17 relatived pathway. Methods: Flow cytometry was used to evaluate the level of Th17 and Treg in the peripheral blood samples of OSCC patients and control group. Th17 and Treg in The tumor microenvironment were detected too and the relation between them was evaluated. Stable transfection was performed to transfect human tongue carcinoma cell line TCA8113 with human-IL-17a gene. TCA8113/IL-17 cell and hu-PBL -SCID-beige mice were used to investigate the change of the tumor microenvironment and the possible mechanism of how Th17 inhibite the OSCC tumor grow. Results: The level of Th17 cells in the peripheral blood of OSCC patients is higher than the normal control group; The level of CD4 + CD25high CD127lowT cell in peripheral blood of OSCC patients was higher than the normal control. The level of CD31+Treg in peripheral blood of OSCC patients was higher than the normal control. Th17 cells and Treg infiltration were found in the local tumor microenvironment of OSCC and a inverse relationship between them was found. The second part: TCA8113/IL-17 cell which stable express IL-17A was successfully established, and the shape was good. The proliferation of cells in vitro was samiliar to TCA8113 and TCA8113/PCDNA3.1 cells.The Hu-PBL-SCID-beige mice immune reconstitution model was successfully established, and human-IgG can be detected in peripheral blood of all mice with an average concentration of 2.105g/L. The success rate of reconstruction was 100%.Experimental mouse model of OSCC were constructed with TCA8113, TCA8113/IL-17, and TCA8113/pcDNA3.1 cell. Success rate was 95%.Tumor growth rate in T +17 group was lower than T and T+P group. The final tumor volume of T+17 group (1.219 ± 0.626cm3) was lower than T group (2.858 ± 1.188cm3) and T+P group (2.59±1.199 cm3).The mRNA and protein expression levels of IL-17a, IL-6, granzyme B and RORγt in T+17 group were higher than the T group and T + P group. Conclusion:Th17 and Treg levels of peripheral blood were increased in OSCC patients, but there was no relation between them. The immune environment in OSCC patients was in a suppressive state. CD4 + CD25highCD127low was a better way than o CD4+CD25highFoxP3+ to marked Treg in OSCC. Infiltration of Th17 and Treg in tumor microenviroment could be evaluated, and negative correlation between them could be investigated. Treg in the OSCC microenvironment may inhibited the Th17 differentiation and function. Citation Format: Rongfa Bu. The role of Th17 cells in the microenvironment of oral squamous cell carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3990. doi:10.1158/1538-7445.AM2013-3990
SP0168 How to Get A SESSION Proposal Accepted: Practical Tips
Authors: R. Ferreira
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> EULAR endeavours to stimulate the participation and representation of all European nations, in order to promote better care to people with rheumatic diseases. It does not matter if your country has developed care in this field, you can be involved in the EULAR Health Professionals work. This lecture aims to present some practical tips about how to get a session proposal accepted, and how to influence the EULAR-HP discussion. Two sessions accepted in the EULAR 2014 will be given as example, describing how the process was performed. The contribution of EULAR education grants will be addressed as well. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6244
FREQUENCY AND PROGNOSTIC IMPACT OF INTRAVASCULAR IMAGING-GUIDED URGENT PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION: RESULTS FROM J-MINUET
Authors: Hiroyuki Okura, Masaharu Ishihara, Masashi Fujino, Hisao Ogawa, Koichi Nakao, Satoshi Yasuda, Teruo Noguchi, Yukio Ozaki, Kazuo Kimura, Satoru Suwa, Kazuteru Fujimoto, Yasuharu Nakama, Takashi Morita, Wataru Shimizu, Yoshihiko Saito, Atsushi Hirohata, Yasuhiro Morita, Teruo Inoue, Atsunori Okamura, Masaaki Uematsu, Kazuhito Hirata, Kengo Tanabe, Yoshisato Shibata, Mafumi Owa, Seiji Hokimoto
Journal: Journal of the American College of Cardiology (2016)
Circulating microRNAs in metastatic colorectal cancer (mCRC) patients (pts) treated with regorafenib
Authors: C. Antoniotti, F. Loupakis, M. Schirripa, C. Cremolini, L. Poliseno, L. Salvatore, A. Tuccoli, R. D'Aurizio, F. Marmorino, B. Borelli, D. Rossini, A. Saettini, S. Gini, R. Moretto, I. Rizzo, E. Dell'Aquila, M. Pellegrini, A. Falcone
Journal: Annals of Oncology (2015)
Case 16-2010
Authors: Benjamin D. Medoff, Gerald F. Abbott, Abner Louissaint
Journal: New England Journal of Medicine (2010)

A 48-year-old man was seen at this hospital because of cough and pain and a lytic lesion in the scapula. He had been well until 2.5 months earlier, when a cough and scapular pain developed; a chest radiograph reportedly revealed pneumonia and a lytic lesion in the scapula. An excisional biopsy of the scapular lesion showed granulomatous osteomyelitis; all cultures were negative. Computed tomography of the chest revealed reticulonodular infiltrates and cystic lesions in the upper lungs. A diagnostic procedure was performed.
Magnetic-Affinity Cell Sorting of Human Multidrug-Resistant Cells
Authors: R. Padmanabhan, T. Tsuruo, S. E. Kane, M. C. Willingham, B. H. Howard, M. M. Gottesman, I. Pastan
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Magnetic-Affinity Cell Sorting of Human Multidrug-Resistant Cells Get access Raji Padmanabhan, Raji Padmanabhan Laboratory of Cell Biology, National Cancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar Takashi Tsuruo, Takashi Tsuruo Division of Experimental Chemotherapy, Cancer Chemotherapy Center, Japanese Foundation for Cancer ResearchTokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Susan E. Kane, Susan E. Kane Laboratory of Cell Biology, National Cancer InstituteBethesda, Md Present address: S. E. Kane, Department of Cell and Tumor Biology, City of Hope Medical Center, Duarte, Calif Search for other works by this author on: Oxford Academic PubMed Google Scholar Mark C. Willingham, Mark C. Willingham Laboratory of Molecular Biology, National C4ancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar Bruce H. Howard, Bruce H. Howard Laboratory of Molecular Biology, National C4ancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael M. Gottesman, Michael M. Gottesman * Laboratory of Cell Biology, National Cancer InstituteBethesda, Md *Correspondence to: Michael M. Gottesman, MD, Laboratory of Cell Biology, Bldg 37, Rm IB22, National Institutes of Health, Bethesda, MD 20892. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ira Pastan Ira Pastan Laboratory of Molecular Biology, National C4ancer InstituteBethesda, Md Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 8, 17 April 1991, Pages 565–569, https://doi.org/10.1093/jnci/83.8.565 Published: 17 April 1991 Article history Received: 29 June 1990 Revision received: 08 January 1991 Accepted: 04 February 1991 Published: 17 April 1991
Metaplastic breast carcinoma: clinicopathologic features and prognostic value of triple-negativity.
Authors: K Lim, D Oh, E Chie, W Han, S Im, T Kim, I Park, D Nho, S Ha, Y Bang
Journal: Cancer Research (2009)

Abstract Abstract #1085 Backgroud Metaplastic breast carcinomas (MBC) are a rare type of breast cancer comprising &amp;lt;1% of all invasive breast cancers and are generally characterized by hormone receptor and human epidermal growth factor receptor 2 (HER2) negativity. There is a paucity of information on prognosis according to hormone receptor and HER2 expression for these rare tumors. The aim of this study was to compare the clinical features and prognosis, between triple negative metaplastic carcinoma (TNMC) and non-triple negative metaplastic carcinoma (NTNMC).&amp;#x2028; Material and Methods We retrospectively analyzed MBC patients treated at Seoul National University Hospital between 1996 and 2006. Pathologic, immunohistochemical findings and clinical outcome information were reviewed.&amp;#x2028; Results fifty-one patients were identified. The median age at presentation was 45.8 years (range: 27.3-83.8). Median tumor size at diagnosis was 3.0 cm (range: 0.8-12.0). 34 cases (66.7%) were node-negative, 16 (31.4%) node-positive, and 1 (2.0%) were missing. Estrogen receptor (ER)/progesterone receptor (PR) yielded negative results in 49 cases (96.1%) and 48 cases (94.1%), respectively. HER2 overexpression by immunohistochemistry was negative in 41 of 51 (80.4%). At median follow-up of 40.8 months, the 5-year overall survival rate and disease free survival were 73.9% and 64.9%, respectively. Non-triple negativity (p=0.031) correlated significant with overall survival in multivariate analysis.&amp;#x2028; Of the 51 patients, 39 (76.5%) were TNMC, and 12 (23.5%) were NTNMC. In TNMC and NTNMC group, median ages were 45.6 and 51.5 years and tumor sizes were 3.0 cm and 3.0 cm, respectively. There were 12 patients (30.8%) in TNMC and 4 patients (33.3%) in NTNMC for lymph node metastasis. Two groups did not differ significantly by age, tumor size, or nodal status. Positive rates for ER, PR and HER2 were 16.7%, 25% and 83.3% in NTNMC. The 3-year overall survival rates in TNMC and NTNMC were 91.4% and 61.9%, respectively (p=0.029). As regards to 3-years disease-free survival, there was no statistically significant difference between TNMC and NTNMC (p=0.694, 75.8% versus 75.0%).&amp;#x2028; Discussion MBC mainly has triple negative features. However, in subgroup analysis of MBC, non-triple negative group displayed a poor prognosis compared with triple negative group, which is contrary to the case of invasive ductal carcinoma of breast. Further research exploring mechanism of this result. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1085.
Case 28-2013
Authors: David F.M. Brown, Farouc A. Jaffer, Joshua N. Baker, M. Edip Gurol
Journal: New England Journal of Medicine (2013)

A 52-year-old man was brought to the emergency department with chest pain and ST-segment elevation. Seconds after his arrival, cardiac arrest occurred. CPR was begun, and nine external countershocks were administered, without resolution. Management decisions were made.
1019 URINARY NGAL IS USEFUL TO PREDICT CAUSE AND SEVERITY OF KIDNEY FUNCTION IMPAIRMENT AND IS A PROGNOSTIC MARKER IN PATIENTS HOSPITALIZED FOR COMPLICATIONS OF CIRRHOSIS
Authors: R. Barreto, C. Fagundes, R. Moreira, E. Rodriguez, R. Cela, S. Elsa, I. Graupera, X. Ariza, G. Pereira, M. Morales, E. Poch, W. Jiménez, M. Guevara, V. Arroyo, P. Ginès
Journal: Journal of Hepatology (2013)
SP0096 Promoting Awareness and the Ability to Adapt and Self-Manage the Conditions to Improve the Suitability of Work in Fibromyalgia
Authors: R. Geenen
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Work is a way to contribute to society, to meet other people, to structure everyday life, and to have an income that can help to live a valuable life. Despite these merits, work is also a burden when pain, low energy levels, and musculoskeletal problems hamper the performance of tasks, or when commuting between home and work causes strain, and superiors or colleagues do not understand the consequences of fibromyalgia. To reduce the burden of work, employers are often imposed upon to make adaptations in the working hours, tasks or environment of employed patients, for example, by letting them work less hours, start later in the day, have a restricted physical work load, or have technical aids available. These adaptations do mostly not take into account other factors that may play a role in the work ability of patients with fibromyalgia, such as their home situation. In the Netherlands, researchers and patient representatives together have identified all relevant characteristics of suitable work as perceived by patients with fibromyalgia (1). The subsequent step was to develop an instrument that people with fibromyalgia can use to become aware of the conditions that will make their work more suitable for them. The name of the new instrument is 'Passport Suitable Work'. The first part of the booklet includes a forced choice format that helps individual employees to become aware of the characteristics of suitable work that are important for them. The next part of the booklet offers tools that employees can use to negotiate with their employer and company physician to improve the match between job demands and capabilities. The 'passport' that was introduced in the past month is an example of an active and dynamic way to adapt to and self-manage the challenge of work. We expect that both employees with fibromyalgia and employers are positive about people with fibromyalgia becoming more active partners in discussions aimed to improve the suitability of their work. Bossema ER, Kool MB, Cornet D, Vermaas P, de Jong M, van Middendorp H &amp; Geenen R. Characteristics of suitable work from the perspective of patients with fibromyalgia. Rheumatology 2012;51:311-8. <h3>Disclosure of Interest</h3> None Declared
An alternative view of the neurobiology of dreaming
Authors: G W Vogel
Journal: American Journal of Psychiatry (1978)

The author critiques the recently proposed activation-synthesis hypothesis about the origin and formation of dreams. Many findings do not support the new hypothesis that specific pontine physiological processes, rather than mental processes, instigate dreams and produce their distortion. First, dreaming often occurs in the absence of the pontine processes. Second, forebrain activity (which can have mental correlates) is crucial to the instigation and maintenance of dreaming sleep. Finally, activity of the proposed pontine dream generator, which is claimed to cause dream distortion, is not reliably accompanied by dream distortion.
Abstract 1152: Identification of protein tyrosine kinase 7 gene in hepatocellular carcinoma using a novel triple-combination array analysis.
Authors: Mitsuhiro Hishida, Shuji Nomoto, Yoshikuni Inokawa, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Shin Takeda, Yasuhiro Kodera
Journal: Cancer Research (2013)

Abstract Background. Hepatocellular carcinoma (HCC) is one of the top five causes of cancer-related deaths worldwide. Recent developments in the treatment of HCC still have failed to prevent HCC. Genome-wide gene-expression profile analyses can now detect many candidate genes that are modified by HCC. We have developed a new technique to identify suppressor genes of HCC: triple-combination array analysis, which combines gene expression profile, single nucleotide polymorphism array and methylation array. Methods. Triple-combination array analysis was performed on one HCC sample from a 68-year-old female patient, and one candidate of tumor suppressor gene was selected. Subsequently, we analyzed the identified gene by quantitative real-time reverse-transcriptase polymerase chain reaction (PCR) and methylation-specific PCR in samples from 48 HCC patients and in nine cell lines. Results. Using this method, protein tyrosine kinase 7 (PTK7) was detected as a candidate of tumor suppressor gene. PTK7 gene is located on 6q21.2, and expression was reduced in HCC tissues at the high level of -2.5 compared with normal tissues. PTK7 locus did not show any deletion or amplification in the SNP array. The methylation value (0-1.0) in the tumor sample was 0.825 compared to 0.047 in normal tissues, indicating high methylation in tumor tissues in the methylation array. Of the 48 clinical samples, 30 (62.5%) showed PTK7 promoter hypermethylation. The PTK7 promoter hypermethylated cases were significantly low expressions status (P=0.035), and bad prognosis in both overall survival (P&amp;lt;0.01) and recurrence-free survival (P=0.018) compared to hypomethylated cases. On the other hand, the cases, of which the PTK7 expressions in tumor tissues decreased by more than 20% degrees compared to those in normal tissues, were significantly worse prognosis in overall survival (P=0.0136) than the other cases, but not in recurrence-free survival (P=0.3102). Conclusions. We suggest that the PTK7 gene acts as a tumor suppressor gene in HCC. This present study indicates that triple-combination array is an available and convenient technique for detecting the genes with altered expression in disease. Citation Format: Mitsuhiro Hishida, Shuji Nomoto, Yoshikuni Inokawa, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Shin Takeda, Yasuhiro Kodera. Identification of protein tyrosine kinase 7 gene in hepatocellular carcinoma using a novel triple-combination array analysis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1152. doi:10.1158/1538-7445.AM2013-1152
A2.2 Pro-inflammatory macrophages mediated TNF-alpha signalling is required for caudal fin regenerationin zebrafish larvae
Authors: B Laplace-Builhe, M Nguyen-Chi, J Travnickova, P Luz-Crawford, G Tejedor, K Kissa, G Lutfalla, C Jorgensen, F Djouad
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Introduction</h3> Macrophages play an important role in the immune response to injury. However, a broader role in repair and regeneration has been reported. While macrophage ablation impairs epithelialisation and reduces scar formation in skin repair model in mammals, it impairs the regeneration of the limb in axolotl and of the fin in adult zebrafish. This discrepancy is likely due to the high plasticity of macrophages, which can adopt various phenotypes and functions. Here we used the zebrafish larva to study the role of pro-inflammatory, M1-like macrophages during caudal fin regeneration. <h3>Materials, methods and results</h3> Using 4D confocal microscopy and double transgenic larvae to visualise macrophages and TNF-α producer cells, we showed that initially most recruited macrophages expressed TNF-α (referred as M1-like). However TNF-α expression was transient and decreased from 24 h post amputation, due to the recruitment of a second wave of non-inflammatory macrophages (referred as M2-like) and to a local phenotypic conversion of macrophages. We demonstrated that TNF-α expressing macrophages were crucial for fin regeneration as early depletion of macrophages blocked blastema formation and regeneration process, while the depletion of late M2-like macrophages did not. We then turned our attention to the trophic control exerted by M1-like macrophages on the regeneration process and investigated the role of TNF-α signalling. Using a combination of morpholino knock down strategy and parabiosis experiments, we showed that TNFR1 played a necessary and direct role in the induction of fin regeneration by expanding blastemal cell. <h3>Conclusion</h3> In summary the present data strongly suggest that TNF-α producing macrophages stimulate blastemal cell proliferation through the TNFR1 activation, revealing a new insight into the mechanism of caudal fin regeneration.
An Association between Air Pollution and Mortality in Six U.S. Cities
Authors: Douglas W. Dockery, C. Arden Pope, Xiping Xu, John D. Spengler, James H. Ware, Martha E. Fay, Benjamin G. Ferris, Frank E. Speizer
Journal: New England Journal of Medicine (1993)

Recent studies have reported associations between particulate air pollution and daily mortality rates. Population-based, cross-sectional studies of metropolitan areas in the United States have also found associations between particulate air pollution and annual mortality rates, but these studies have been criticized, in part because they did not directly control for cigarette smoking and other health risks.In this prospective cohort study, we estimated the effects of air pollution on mortality, while controlling for individual risk factors. Survival analysis, including Cox proportional-hazards regression modeling, was conducted with data from a 14-to-16-year mortality follow-up of 8111 adults in six U.S. cities.Mortality rates were most strongly associated with cigarette smoking. After adjusting for smoking and other risk factors, we observed statistically significant and robust associations between air pollution and mortality. The adjusted mortality-rate ratio for the most polluted of the cities as compared with the least polluted was 1.26 (95 percent confidence interval, 1.08 to 1.47). Air pollution was positively associated with death from lung cancer and cardiopulmonary disease but not with death from other causes considered together. Mortality was most strongly associated with air pollution with fine particulates, including sulfates.Although the effects of other, unmeasured risk factors cannot be excluded with certainty, these results suggest that fine-particulate air pollution, or a more complex pollution mixture associated with fine particulate matter, contributes to excess mortality in certain U.S. cities.
Intense Uptake of In-111 Satumomab Pendetide in an Inflammatory Mass
Authors: EDWARD B. SILBERSTEIN, EDWARD SAEKS
Journal: Clinical Nuclear Medicine (1996)

Intensely increased upper abdominal uptake of In-111 labeled anti-tumor associated glycoprotein in a patient with a history of pancreatic carcinoma persisted over 6 days in the same location. At laparotomy chronic inflammation, fibrosis, calcification, and lymph node granulomas were found, but no tumor. The patient remained tumor free 8 months later.
Abstract LB-40: How patient advocacy can positively impact clinical research
Authors: Grace E. Schroer
Journal: Cancer Research (2012)

Abstract The Bladder Cancer Advocacy Network (BCAN) was the first national patient advocacy group to focus on blader cancer. Since its establishment in 2005, BCAN has put forth a number of programs designed to advance the three goals of our mission; raising awareness of bladder cancer, providing education and support to the bladder cancer community and advancing bladder cancer research. As part of BCAN's mission to advance to advance research, they has sought to encourage collaboration among physicians and research who are dedicated to the study of bladder cancer and its prevention, diagnosis and treatment by hosting an annual scientific Think Tank meeting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-40. doi:1538-7445.AM2012-LB-40