tbuckley/cabot-search huggingface dataset:
Changing Outcomes in Pregnant Surgical Patients
Authors: Roxanne L. Massoumi, O. Joe Hines
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
FIP1L1/PDGFRα Imposes Commitment towards Eosinophil Lineage on Hematopoietic Stem/Progenitor Cells by Modifying the Expression and Function of Lineage Specific Transcription Factors.
Authors: Kentaro Fukushima, Itaru Matsumura, Sachiko Ezoe, Hirohiko Shibayama, Michiko Ichii, Takafumi Yokota, Hirokazu Tanaka, Yuzuru Kanakura
Journal: Blood (2007)
The Impact of Postoperative Radiotherapy for Thymoma and Thymic Carcinoma
Authors: Matthew W. Jackson, David A. Palma, D. Ross Camidge, Bernard L. Jones, Tyler P. Robin, David J. Sher, Matthew Koshy, Brian D. Kavanagh, Laurie E. Gaspar, Chad G. Rusthoven
Journal: Journal of Thoracic Oncology (2017)
The Non-Death Domain Containing TNFR Member HVEM Induces Apoptosis and Chemokine Production on B-Chronic Lymphocytic Leukemia Cells.
Authors: Daniel R. Olive, Christine Pasero, Bernadette Barbarat, Alem Truneh, Sylvaine Just, Therese Aurrand, Jerome Rey, Regis T. Costello
Journal: Blood (2007)
A Metabolome-Wide Study of Dry Eye Disease Reveals Serum Androgens as Biomarkers
Authors: Jelle Vehof, Pirro G. Hysi, Christopher J. Hammond
Journal: Ophthalmology (2017)

<h3>Purpose</h3> To test the association between serum metabolites and dry eye disease (DED) using a hypothesis-free metabolomics approach. <h3>Design</h3> Cross-sectional association study. <h3>Participants</h3> A total of 2819 subjects from the population-representative TwinsUK cohort in the United Kingdom, with a mean age of 57 years (range, 17–82 years). <h3>Methods</h3> We tested associations between 222 known serum metabolites and DED. All subjects underwent nontargeted metabolomic analysis of plasma samples using gas and liquid chromatography in combination with mass spectrometry (Metabolon Inc., Durham, NC). Dry eye disease was defined from the validated Short Questionnaire for Dry Eye Syndrome (SQDES) as a previous diagnosis of DED by a clinician or "often" or "constant" symptoms of dryness and irritation. Analyses were performed with linear mixed effect models that included age, BMI, and sex as covariates, corrected for multiple testing. <h3>Main Outcome Measures</h3> Primary outcome was DED as defined by the SQDES, and secondary outcomes were symptom score of DED and a clinical diagnosis of DED. <h3>Results</h3> Prevalence of DED as defined by the SQDES was 15.5% (n = 436). A strong and metabolome-wide significant association with DED was found with decreased levels of the metabolites androsterone sulfate (<i>P</i> = 0.00030) and epiandrosterone sulfate (<i>P</i> = 0.00036). Three other metabolites involved in androgen metabolism, 4-androsten-3beta,17beta-diol disulfate 1 and 2, and dehydroepiandrosterone sulfate, were the next most strongly associated of the 222 metabolites, but did not reach metabolome-wide significance. Dryness and irritation symptoms, as opposed to a clinical diagnosis, were particularly strongly associated with decreased androgen steroid metabolites, with all reaching metabolome-wide significance (androsterone sulfate, <i>P</i> = 0.000000029; epiandrosterone sulfate, <i>P</i> = 0.0000040; 4-androsten-3beta,17beta-diol disulfate 1, <i>P</i> = 0.000016; 4-androsten-3beta,17beta-diol disulfate 2, <i>P</i> = 0.000064; and dehydroepiandrosterone sulfate, <i>P</i> = 0.00011). Of these 5 androgens, epiandrosterone sulfate (<i>P</i> = 0.0076) was most associated with 2-year incidence of clinician-diagnosed DED. In addition, we found decreased glycerophosphocholines to be associated with DED, although not at metabolome-wide significance. <h3>Conclusions</h3> This hypothesis-free metabolomic approach found decreased serum androgens to be highly associated with DED and adds important evidence to the growing body of research that links androgens to ocular surface disease and DED.
Tight Glycemic Control in Critically Ill Children
Authors: Michael S.D. Agus, David Wypij, Eliotte L. Hirshberg, Vijay Srinivasan, E. Vincent Faustino, Peter M. Luckett, Jamin L. Alexander, Lisa A. Asaro, Martha A.Q. Curley, Garry M. Steil, Vinay M. Nadkarni
Journal: New England Journal of Medicine (2017)

In multicenter studies, tight glycemic control targeting a normal blood glucose level has not been shown to improve outcomes in critically ill adults or children after cardiac surgery. Studies involving critically ill children who have not undergone cardiac surgery are lacking.
Halofuginone, a Novel Antimyeloma Agent, Upregulates C-Jun, JNK and P-53 Protein in Vitro, and Inhibits Tumor Growth and Improves Survival in in Vivo Multiple Myeloma(MM) Animal Models
Authors: Merav Leiba, Jana Jakubikova, Steffen Klippel, Constantine S. Mitsiades, Teru Hideshima, Yu-Tzu Tai, Paul Richardson, Yutaka Okawa, Hiroshi Ikeda, Arnon Nagler, Kenneth C. Anderson
Journal: Blood (2008)
Elevating CXCR7 Improves Angiogenic Function of EPCs via Akt/GSK-3β/Fyn-Mediated Nrf2 Activation in Diabetic Limb Ischemia
Authors: Xiaozhen Dai, Xiaoqing Yan, Jun Zeng, Jing Chen, Yuehui Wang, Jun Chen, Yan Li, Michelle T. Barati, Kupper A. Wintergerst, Kejian Pan, Matthew A. Nystoriak, Daniel J. Conklin, Gregg Rokosh, Paul N. Epstein, Xiaokun Li, Yi Tan
Journal: Circulation Research (2017)

Rationale: Endothelial progenitor cells (EPCs) respond to stromal cell–derived factor 1 (SDF-1) through chemokine receptors CXCR7 and CXCR4. Whether SDF-1 receptors involves in diabetes mellitus–induced EPCs dysfunction remains unknown. Objective: To determine the role of SDF-1 receptors in diabetic EPCs dysfunction. Methods and Results: CXCR7 expression, but not CXCR4 was reduced in EPCs from db/db mice, which coincided with impaired tube formation. Knockdown of CXCR7 impaired tube formation of EPCs from normal mice, whereas upregulation of CXCR7 rescued angiogenic function of EPCs from db/db mice. In normal EPCs treated with oxidized low-density lipoprotein or high glucose also reduced CXCR7 expression, impaired tube formation, and increased oxidative stress and apoptosis. The damaging effects of oxidized low-density lipoprotein or high glucose were markedly reduced by SDF-1 pretreatment in EPCs transduced with CXCR7 lentivirus but not in EPCs transduced with control lentivirus. Most importantly, EPCs transduced with CXCR7 lentivirus were superior to EPCs transduced with control lentivirus for therapy of ischemic limbs in db/db mice. Mechanistic studies demonstrated that oxidized low-density lipoprotein or high glucose inhibited protein kinase B and glycogen synthase kinase-3β phosphorylation, nuclear export of Fyn and nuclear localization of nuclear factor (erythroid-derived 2)-like 2 (Nrf2), blunting Nrf2 downstream target genes heme oxygenase-1, NAD(P)H dehydrogenase (quinone 1) and catalase, and inducing an increase in EPC oxidative stress. This destructive cascade was blocked by SDF-1 treatment in EPCs transduced with CXCR7 lentivirus. Furthermore, inhibition of phosphatidylinositol 3-kinase/protein kinase B prevented SDF-1/CXCR7-mediated Nrf2 activation and blocked angiogenic repair. Moreover, Nrf2 knockdown almost completely abolished the protective effects of SDF-1/CXCR7 on EPC function in vitro and in vivo. Conclusions: Elevated expression of CXCR7 enhances EPC resistance to diabetes mellitus–induced oxidative damage and improves therapeutic efficacy of EPCs in treating diabetic limb ischemia. The benefits of CXCR7 are mediated predominantly by a protein kinase B/glycogen synthase kinase-3β/Fyn pathway via increased activity of Nrf2.
Delirium, Dementia, and Decline
Authors: Tamara G. Fong, Sharon K. Inouye, Richard N. Jones
Journal: JAMA Psychiatry (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Pokémon GO: are limited physical activity benefits undermined by McFlurries consumed?
Authors: Mohammed Jawad, Anthony A Laverty, Christopher Millett
Journal: BMJ (2017)

We welcome attempts from Howe and colleagues to evaluate the impact of Pokemon GO,1 which is the most downloaded smartphone app of all time. This, and nearly all other known Pokemon GO analyses, limit their investigations to the number of steps taken or other markers of physical activity.23 But what about changes in diet?

Central to players’ progression through …
Phase II Study of the Pan-Deacetylase Inhibitor Panobinostat in Combination with Bortezomib and Dexamethasone in Relapsed and Bortezomib-Refractory Multiple Myeloma (PANORAMA 2)
Authors: Paul G. Richardson, Melissa Alsina, Donna M. Weber, Steven E. Coutre, Sagar Lonial, Cristina Gasparetto, Ghulam Warsi, Michael Ondovik, Sutapa Mukhopadhyay, Susan Snodgrass, Robert Schlossman
Journal: Blood (2011)
Improved Cell Viability, Viable Cell Recovery and Faster Engraftment of Products Thawed Using a Premixed Solution of Human Serum Albumin and Dextran 40 Compared to Sequential Addition During the Thawing Procedure
Authors: Carolyn A. Keever-Taylor, Steve Konings, Sarah M Heidtke, Hong Zeng, Sara A Wieczorek, Allen Tsao, David A Margolis
Journal: Blood (2010)
New strategies for cancer immunotherapy: targeting regulatory T cells
Authors: Francesca Finotello, Zlatko Trajanoski
Journal: Genome Medicine (2017)

The immunosuppressive action of regulatory T (Treg) cells is one mechanism attributed to the limited success of cancer immunotherapies with checkpoint blockers. Two recent studies report distinct transcriptional profiles of tumor-infiltrating Treg cells and expression of specific molecules, suggesting novel strategies to overcome resistance to cancer immunotherapy.
Overexpression of CXCR4 in Acute Myeloid Leukemia Predicts Adverse Overall and Progression-Free Survival Independently of FLT3 Gene Mutation.
Authors: Sergej Konoplev, George Z. Rassidakis, Elihu H. Estey, Hagop M. Kantarjian, Xuelin Huang, Lianchun Xiao, Michael Andreeff, Marina Konopleva, L. Jeffrey Medeiros
Journal: Blood (2006)
Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the <i>APOE</i> ε4 Genotype
Authors: Janina Krell-Roesch, Prashanthi Vemuri, Anna Pink, Rosebud O. Roberts, Gorazd B. Stokin, Michelle M. Mielke, Teresa J. H. Christianson, David S. Knopman, Ronald C. Petersen, Walter K. Kremers, Yonas E. Geda
Journal: JAMA Neurology (2017)

Cross-sectional associations between engagement in mentally stimulating activities and decreased odds of having mild cognitive impairment (MCI) or Alzheimer disease have been reported. However, little is known about the longitudinal outcome of incident MCI as predicted by late-life (aged ≥70 years) mentally stimulating activities.To test the hypothesis of an association between mentally stimulating activities in late life and the risk of incident MCI and to evaluate the influence of the apolipoprotein E (APOE) ε4 genotype.This investigation was a prospective, population-based cohort study of participants in the Mayo Clinic Study of Aging in Olmsted County, Minnesota. Participants 70 years or older who were cognitively normal at baseline were followed up to the outcome of incident MCI. The study dates were April 2006 to June 2016.At baseline, participants provided information about mentally stimulating activities within 1 year before enrollment into the study. Neurocognitive assessment was conducted at baseline, with evaluations at 15-month intervals. Cognitive diagnosis was made by an expert consensus panel based on published criteria. Hazard ratios (HRs) and 95% CIs were calculated using Cox proportional hazards regression models after adjusting for sex, age, and educational level.The final cohort consisted of 1929 cognitively normal persons (median age at baseline, 77 years [interquartile range, 74-82 years]; 50.4% [n = 973] female) who were followed up to the outcome of incident MCI. During a median follow-up period of 4.0 years, it was observed that playing games (HR, 0.78; 95% CI, 0.65-0.95) and engaging in craft activities (HR, 0.72; 95% CI, 0.57-0.90), computer use (HR, 0.70; 95% CI, 0.57-0.85), and social activities (HR, 0.77; 95% CI, 0.63-0.94) were associated with a decreased risk of incident MCI. In a stratified analysis by APOE ε4 carrier status, the data point toward the lowest risk of incident MCI for APOE ɛ4 noncarriers who engage in mentally stimulating activities (eg, computer use: HR, 0.73; 95% CI, 0.58-0.92) and toward the highest risk of incident MCI for APOE ɛ4 carriers who do not engage in mentally stimulating activities (eg, no computer use: HR, 1.74; 95% CI, 1.33-2.27).Cognitively normal elderly individuals who engage in specific mentally stimulating activities even in late life have a decreased risk of incident MCI. The associations may vary by APOE ε4 carrier status.
The IgM receptor FcμR limits tonic BCR signaling by regulating expression of the IgM BCR
Authors: Trang T T Nguyen, Kathrin Kläsener, Christa Zürn, Patricia A Castillo, Ingrid Brust-Mascher, Denise M Imai, Charles L Bevins, Colin Reardon, Michael Reth, Nicole Baumgarth
Journal: Nature Immunology (2017)
Real-Time In Vivo Biodistribution of Multipotent Adult Progenitor Cells (MAPC): Role of the Immune System in MAPC Resistance in Non-Transplanted and Bone Marrow Transplanted Mice.
Authors: Jakub Tolar, Scott Bell, Ron McElmurry, Lily Xia, R. Scott McIvor, Stephen R. Yant, Mark A. Kay, Christopher H. Contag, Catherine M. Verfaillie, Bruce R. Blazar
Journal: Blood (2004)
miR-18a-5p Inhibits Sub-pleural Pulmonary Fibrosis by Targeting TGF-β Receptor II
Authors: Qian Zhang, Hong Ye, Fei Xiang, Lin-Jie Song, Li-Ling Zhou, Peng-Cheng Cai, Jian-Chu Zhang, Fan Yu, Huan-Zhong Shi, Yunchao Su, Jian-Bao Xin, Wan-Li Ma
Journal: Molecular Therapy (2017)

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease that typically leads to respiratory failure and death within 3–5 years of diagnosis. Sub-pleural pulmonary fibrosis is a pathological hallmark of IPF. Bleomycin treatment of mice is a an established pulmonary fibrosis model. We recently showed that bleomycin-induced epithelial-mesenchymal transition (EMT) contributes to pleural mesothelial cell (PMC) migration and sub-pleural pulmonary fibrosis. MicroRNA (miRNA) expression has recently been implicated in the pathogenesis of IPF. However, changes in miRNA expression in PMCs and sub-pleural fibrosis have not been reported. Using cultured PMCs and a pulmonary fibrosis animal model, we found that miR-18a-5p was reduced in PMCs treated with bleomycin and that downregulation of miR-18a-5p contributed to EMT of PMCs. Furthermore, we determined that miR-18a-5p binds to the 3′ UTR region of transforming growth factor β receptor II (TGF-βRII) mRNA, and this is associated with reduced TGF-βRII expression and suppression of TGF-β-Smad2/3 signaling. Overexpression of miR-18a-5p prevented bleomycin-induced EMT of PMC and inhibited bleomycin-induced sub-pleural fibrosis in mice. Taken together, our data indicate that downregulated miR-18a-5p mediates sub-pleural pulmonary fibrosis through upregulation of its target, TGF-βRII, and that overexpression of miR-18a-5p might therefore provide a novel approach to the treatment of IPF. Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease that typically leads to respiratory failure and death within 3–5 years of diagnosis. Sub-pleural pulmonary fibrosis is a pathological hallmark of IPF. Bleomycin treatment of mice is a an established pulmonary fibrosis model. We recently showed that bleomycin-induced epithelial-mesenchymal transition (EMT) contributes to pleural mesothelial cell (PMC) migration and sub-pleural pulmonary fibrosis. MicroRNA (miRNA) expression has recently been implicated in the pathogenesis of IPF. However, changes in miRNA expression in PMCs and sub-pleural fibrosis have not been reported. Using cultured PMCs and a pulmonary fibrosis animal model, we found that miR-18a-5p was reduced in PMCs treated with bleomycin and that downregulation of miR-18a-5p contributed to EMT of PMCs. Furthermore, we determined that miR-18a-5p binds to the 3′ UTR region of transforming growth factor β receptor II (TGF-βRII) mRNA, and this is associated with reduced TGF-βRII expression and suppression of TGF-β-Smad2/3 signaling. Overexpression of miR-18a-5p prevented bleomycin-induced EMT of PMC and inhibited bleomycin-induced sub-pleural fibrosis in mice. Taken together, our data indicate that downregulated miR-18a-5p mediates sub-pleural pulmonary fibrosis through upregulation of its target, TGF-βRII, and that overexpression of miR-18a-5p might therefore provide a novel approach to the treatment of IPF.
Alemtuzumab for Treatment of Acute Gvhd In Steroid-Refractory Patients.
Authors: Alexandre Sucupira, Mauricio Ostronoff, Fabiana Ostronoff, ANA Patricia Souto Maior, Jose Carlos Freitas, Rodrigo Florencio, Luis Fabio Botelho, Monique Martins, Rodolfo Calixto
Journal: Blood (2010)
A Faculty-Student Mentoring Program to Enhance Collaboration in Public Health Research in Surgery
Authors: Blair J. Smart, R. Sterling Haring, Cheryl K. Zogg, Marie Diener-West, Eric B. Schneider, Adil H. Haider, Elliott R. Haut
Journal: JAMA Surgery (2017)

This study reports participant characteristics and academic productivity of a structured mentoring program combining the disciplines of public health research and surgery to enhance the academic experience for students and faculty.
Clonal Changes Are Frequent in Relapsed TEL-AML1+ ALL and Predominate in Young Children.
Authors: Renate Panzer-Grümayer, Giovanni Cazzaniga, Vincent van der Velden, Laura del Giudice, Martina Peham, Conny Eckert, Andre Schrauder, Jochen Harbott, Guiseppe Basso, Andrea Biondi, Jacques van Dongen, Oskar Haas, Helmut Gadner
Journal: Blood (2004)
Intraductal Papillary Mucinous Neoplasm Around the World
Authors: Laura Maggino, Charles M. Vollmer
Journal: JAMA Surgery (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Long Term Results of Fludarabine/Melphalan as Reduced Intensity Conditioning Regimen (RIC) for Transplantation in Mantle Cell Lymphoma (MCL): Age Matters
Authors: Jorge Gayoso, Rodrigo Martino, Pascual Balsalobre, Javier De la Serna, José Francisco Tomás, Alberto Fernandez de Sevilla, David Serrano, Anna Sureda, Jorge Sierra, Jose L. Diez-Martin, Dolores Caballero
Journal: Blood (2008)
Palliative care needs: Symptom reporting during geriatric oncology evaluation.
Authors: Marie Anne Flannery, Chintan Pandya, Mohamedtaki Abdulaziz Tejani, Charles Stewart Kamen, Allison Magnuson, William Dale, Gary R. Morrow, Supriya Gupta Mohile
Journal: Journal of Clinical Oncology (2014)

184 Background: Although extensive descriptive work has been conducted on the symptom experience in cancer, relatively little is known about the specific palliative care needs for geriatric oncology populations. When all age groups are studied older individuals report less symptoms and the symptom experience of older cancer patients is minimized. Utilizing data collected from two geriatric oncology referral clinics the primary aim of this study was to identify geriatric oncology patients’ symptom reports, the number of symptoms experienced, and interference reported from symptoms. Methods: Patients referred to a geriatric oncology consult clinic were asked to complete the MD Anderson Symptom Inventory (MDASI) total of 13 items. In addition all patients underwent comprehensive geriatric assessment with a battery of tests. Results: 192 patients completed the symptom inventory with a median age of 81 years (range 65-95). 94% of patients reported at least one symptom, &gt;45% reported experiencing 10 of the 13 symptoms (mean number of symptoms =5.7, SD= 3.7). Most frequently reported symptoms were in order: drowsiness, trouble remembering, dry mouth, disturbed sleep, pain, distress, decreased appetitive, dyspnea, and sadness. Severity ratings for individual symptoms M’s= 0.3-2.5, although the complete range of 0-10 was reported. 67% of patients reported that symptoms were interfering with their quality of life, general activity level and walking ability. Conclusions: In contrast to the myth that older cancer patients have minimal symptoms, at time of referral to a geriatric oncology consultation patients report on average experiencing six symptoms which interfere with their quality of life. There is an intersection between geriatric oncology and palliative care and these descriptive findings highlight the importance of systematic symptom assessment for older individuals with cancer to identify needed symptom relief strategies.