tbuckley/cabot-search huggingface dataset:
Inheritance of Diabetes Mellitus
Authors: M B Rosenthal, I D Goldfine, M D Siperstein
Journal: New England Journal of Medicine (1976)

The quotient Q02 is cubic millimeters of 02 (reduced to standard temperature and pressure) used per hour, divided by the weight of the tissue in milligrams after drying at 100°C.Qurea is similarly the number of cubic millimeters of CO2 (reduced to standard temperature and pressure) obtained after the action of urease, divided by the duration of the urea synthesis in hours, and the dry weight of the tissue in milligrams.Summary.-(1)A modification of the Warburg technique is described facilitating the handling and measurement of the respiration of a large number of tissue slices in one vessel.(2) With this technique employing rat liver slices, an increased oxygen consumption was found to accompany the synthesis of urea from ammonium bicarbonate in Ringer's solution.(3) It is pointed out that this process is probably responsible for part (not more than 20 per cent) of the specific dynamic action of protein.
Forensic psychiatry and applied clinical ethics: theory and practice
Authors: J R Ciccone, C Clements
Journal: American Journal of Psychiatry (1984)

The authors briefly describe and then apply a new method--applied clinical ethics--for identifying and working with ethical problems. This method, starting from the clinical context, develops ethical constructs that may be tested in clinical practice and revised if required. The work was done in the context of a combined university-county forensic psychiatric service. The authors discuss three of the identified ethical issues: effects of deinstitutionalization, countertransference with forensic populations, and prediction of dangerousness. They discuss the basis for developing ethical norms from clinical experience and suggest ethical guidelines for medical practice.
Epstein Barr Virus (ebv) of head and neck primary extranodal NHL in Egypt: Pathogenetic mechanism and thrapeutic outcome
Authors: L. M. Sedky, A. Bahnasy, A. Zekry, S. El Housini, N. Mokhtar
Journal: Journal of Clinical Oncology (2004)

9633 Background: PENHL of H&N; represent 16% of all malignant lymphomas at the NCI Cairo. EBV infection is highly associated with lymphoma in immuno-compromised patients, however the situation in immuno-competent patients is still unclear. Method: We investigated 50 Egyptian cases for: EBV association, expression of p53, Ki-67, bcl2,and Bax, in relation to the therapeutic outcome. Results: Phenotype analysis showed B cell type in 31 patients & T cell in 19 cases, distributed in nose & PNS (n=11), nasopharynx (n=11), 13 in tonsils, 7 in oropharynx, and 8 in oral cavity. Using EBER in situ hybridization and PCR, EBV was +ve in 90% and 70% of the cases respectively with 70% concordance between both techniques . Both showed that all the nasal cases (n=10) were EBV +ve. Strain typing revealed the presence of type 1 EBV in all the +ve cases. 24/35 cases scored +ve by PCR, showed 30 base pair deletion of the LMP-1 (del-LMP1) gene, while 11/35 harbored the wild type variant either alone or mixed with del LMP1. A significant difference in the frequency of del-LMP1 was documented between the lymphoma and normal tissues (P<0.05). Protein over-expression was as follows: Ki-67 in 78.1%, p53 in 62.5%, bcl2 in 20% while Bax was abscent in 18% of cases. Multivariate analysis showed that p53 over-expression and advanced disease stage were significantly associated with poor prognosis (P=0.0001). Conclusion: EBV infection is frequent among Egyptian H&N; NHL. The pathogenesis mechanisms may involve p53 deregulation coupled with enhanced proliferation as expressed by high Ki-67 index. The presence of del-LMP1 variants, p53 over-expression and advanced disease stage are associated with poor outcome. No significant financial relationships to disclose.
Desamidation of Amino Acid Amides in Rat-Liver Extracts of Varying Concentrations
Authors: Jose M. Gonçalves, Vincent E. Price, Jesse P. Greenstein
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Desamidation of Amino Acid Amides in Rat-Liver Extracts of Varying Concentrations Get access Jose M. Gonçalves, Jose M. Gonçalves fellow of the Rockefeller Foundation National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincent E. Price, Vincent E. Price assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 281–284, https://doi.org/10.1093/jnci/7.4.281 Published: 01 February 1947 Article history Received: 06 January 1947 Published: 01 February 1947
P18 The impact of Health Protection Agency guidelines on the management of hepatitis B in West Kent
Authors: I Coltart, J Petersen-Camp, M Holland, G Bird
Journal: Gut (2010)

Introduction  In 2006, the Health Protection Agency (HPA) issued standards regarding the follow-up of Hepatitis B infection. West Kent has a catchment population of 655 000 and a local viral hepatitis service.  Aim  We wished to assess the management of Hepatitis B infection within West Kent following the introduction of these guidelines and audit local compliance.  Method  We identified all patients who tested positive for Hepatitis B surface Antigen (HBsAg) over a 2-year period (January 2006 until December 2007) from microbiology records. We examined the referral source, and whether basic demographic, biochemical, and virological parameters had been recorded. In addition, we examined whether the patient was referred to the viral hepatitis service. The referral source was grouped into six categories: Primary Care, Obstetrics, Genito-Urinary Medicine, Occupational Health, General Medicine and “Other”.  Results  21 366 screening tests for Hepatitis B were performed during the 2-year period. Obstetrics accounted for 8299/21 366 (38.8%) of requests, followed by Genito-Urinary Medicine 6998/21 366 (32.8%), Primary Care 4284/21 366 (20.1%), and “Other” with 1128/21 366 (5.2%). Occupational Health (329/21 366) and General medicine (328/21 366) accounted for 1.5% of all screening requests. 89/21 366 (0.4%) of tests were positive for HBsAg. The median age of patients testing positive for HBsAg was 34 years. Ethnicity data were missing in 60% (53/89) of positive results. 59% (52/89) of positive results had been requested in Primary Care, followed by 21% (19/89) in General Medicine, and 11% (10/89) in Genito-Urinary Medicine. 57% (41/89) of patients testing positive for HBsAg had liver function tests checked within 6 months. 44% (39/89) of patients were referred on to specialist hepatology services. 28% (25/89) had radiological imaging following the positive HBsAg result. 6% (5/89) patients met the diagnosis criteria for acute hepatitis B but only two of these patients were referred on to specialist services.  Conclusion  During the 2-year study period, 3.3% of the population in West Kent was tested for Hepatitis B infection. The majority of positive cases were in samples referred from primary care. However, less than half the patients with a positive HBsAg result were referred to specialist services. This contravenes HPA guidelines and leaves patients at risk of developing the sequelae of untreated Hepatitis B infection. Our experience shows that the HPA standards are yet to fully penetrate into routine clinical practice. With thanks to the Department of Microbiology, Maidstone Hospital.
LG-03COMPLETE REMISSION OF AN EXTRA-CRANIALLY DISSEMINATED PLEOMORPHIC XANTHOASTROCYTOMA (PXA) WITH EVEROLIMUS: CASE REPORT AND LITERATURE REVIEW
Authors: Amanda Saraf, Ghada Elhawary, Suzanne Scott, Pournima Navalkele, Diana S. Osorio, Daniel R. Boue', Christopher R. Pierson, Jonathan L. Finlay, Randal Olshefski, Mohamed S. AbdelBaki
Journal: Neuro-Oncology (2016)
Developmental regression of hyaloid vasculature is triggered by neurons
Authors: Yusuke Yoshikawa, Toru Yamada, Ikue Tai-Nagara, Keisuke Okabe, Yuko Kitagawa, Masatsugu Ema, Yoshiaki Kubota
Journal: The Journal of Experimental Medicine (2016)

Vascular development involves not only vascular growth, but also regression of transient or unnecessary vessels. Hyaloid vasculature is the temporary circulatory system in fetal eyes, which spontaneously degenerates when the retinal blood vessels start to grow. Failure of the hyaloid vessels to regress leads to disease in humans, persistent hyperplastic primary vitreous, which causes severe intraocular hemorrhage and impairs visual function. However, the mechanism underlying the endogenous program that mediates spontaneous regression of the hyaloid vessels is not well understood. In this study, we identify a robust switch triggering this program directed by neurons in mice. Marked up-regulation of vascular endothelial growth factor (VEGF) receptor 2 (VEGFR2) occurs in retinal neurons just after birth via distal-multipotent-mesodermal enhancer, a hemangioblast-specific enhancer of VEGFR2. Genetic deletion of neuronal VEGFR2 interrupts this program, resulting in massive hyaloid vessels that persist even during late postnatal days. This abnormality is caused by excessive VEGF proteins in the vitreous cavity as a result of impairment in the neuronal sequestration of VEGF. Collectively, our data indicate that neurons trigger transition from the fetal to the postnatal circulatory systems in the retina.
ΔNp63/DGCR8-Dependent MicroRNAs Mediate Therapeutic Efficacy of HDAC Inhibitors in Cancer
Authors: Marco Napoli, Avinashnarayan Venkatanarayan, Payal Raulji, Brooke A. Meyers, William Norton, Lingegowda S. Mangala, Anil K. Sood, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Harina Vin, Madeleine Duvic, Michael B. Tetzlaff, Jonathan L. Curry, Alain H. Rook, Hussein A. Abbas, Cristian Coarfa, Preethi H. Gunaratne, Kenneth Y. Tsai, Elsa R. Flores
Journal: Cancer Cell (2016)
LG-69PEDIATRIC OPTIC PATHWAY GLIOMAS – THERAPY AND OUTCOMES OVER A DECADE
Authors: Nirav Thacker, Nitya Gulati, Girish Chinnaswamy, Tushar Vora, Maya Prasad, Epari Sridhar, Prakash Shetty, Aliashgar Moiyadi, Tejpal Gupta, Jayant Goda, Rakesh Jalali
Journal: Neuro-Oncology (2016)
HG-108MULTISPECIFIC CHIMERIC ANTIGEN RECEPTOR (CAR) T-CELLS OVERCOME INTER-PATIENT TUMOR HETEROGENEITY AND EXHIBIT ENHANCED ANTITUMOR FUNCTIONALITY IN THE TREATMENT OF GLIOBLASTOMA
Authors: Kevin Bielamowicz, Kristen Fousek, Tiara Byrd, Malani Mukherjee, Nikita Aware, Kevin Chow, Simone Krebs, Zhongzhen Yi, Gianpietro Dotti, Pavel Sumazin, Stephen Gottschalk, Meena Hegde, Nabil Ahmed
Journal: Neuro-Oncology (2016)
Influence of Amethopterin on Tumor Growth and Liver Glutathione Levels of Mice Bearing Lymphocytic Leukemias&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Shacter, Bernard, Law, L. W.
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Influence of Amethopterin on Tumor Growth and Liver Glutathione Levels of Mice Bearing Lymphocytic Leukemias Get access Bernard Shacter, Bernard Shacter National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar L. W. Law L. W. Law National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 3, September 1956, Pages 391–398, https://doi.org/10.1093/jnci/17.3.391 Published: 01 September 1956 Article history Received: 12 June 1956 Published: 01 September 1956
Re: Reecha Sharma, Avi Harlev, Ashok Agarwal, Sandro C. Esteves. Cigarette Smoking and Semen Quality: A New Meta-analysis Examining the Effect of the 2010 World Health Organization Laboratory Methods for the Examination of Human Semen. Eur Urol 2016;70:635–45
Authors: Eugenio Ventimiglia, Francesco Montorsi, Andrea Salonia
Journal: European Urology (2016)
MCP-1, not MIP-1α, Is the Endogenous Chemokine That Cooperates With TGF-β to Inhibit the Cycling of Primitive Normal but not Leukemic (CML) Progenitors in Long-Term Human Marrow Cultures
Authors: J.D. Cashman, C.J. Eaves, A.H. Sarris, A.C. Eaves
Journal: Blood (1998)
Discontinuation of Infliximab in Patients With Ulcerative Colitis Is Associated With Increased Risk of Relapse: A Multinational Retrospective Cohort Study
Authors: Gionata Fiorino, Pablo Navarro Cortes, Pierre Ellul, Carla Felice, Pantelis Karatzas, Marco Silva, Peter L. Lakatos, Fabrizio Bossa, Bella Ungar, Shaji Sebastian, Federica Furfaro, Konstantinos Karmiris, Konstantinos H. Katsanos, Martina Muscat, Dimitrios K. Christodoulou, Giovanni Maconi, Uri Kopylov, Fernando Magro, Gerassimos J. Mantzaris, Alessandro Armuzzi, Marta Maia Boscà-Watts, Shomron Ben-Horin, Stefanos Bonovas, Silvio Danese
Journal: Clinical Gastroenterology and Hepatology (2016)
Deoxyribosidic Compounds in the Novikoff Rat Hepatoma&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Walter C. Schneider
Journal: JNCI Journal of the National Cancer Institute (1957)

Deoxyribosidic Compounds in the Novikoff Rat Hepatoma Get access Walter C. Schneider Walter C. Schneider National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 4, April 1957, Pages 569–578, https://doi.org/10.1093/jnci/18.4.569 Published: 01 April 1957 Article history Received: 13 December 1956 Published: 01 April 1957
170P Ion proton next-generation sequencing for identification of clinically relevent mutations in Moroccan colorectal cancer cases
Authors: F. Azzam, F. Jouali, N. Marchoudi, M. Karkouri, J. Fekkak, D. Squalli Houssaini, Y. Bakri, R. Aboukhalid, S. Amzazi
Journal: Annals of Oncology (2015)
DIABETES AND HYPERTENSION
Authors: E N Smolar
Journal: JAMA (1967)

Diabetes and hypertension have a higher than expected comorbidity. They share common etiology, pathophysiology, and organ effects. Long-term therapeutic goals are to prevent renal failure and atherosclerosis. Management should inhibit pathophysiologic mechanisms and avoid stimulating them. The most appropriate pharmacologic agents to treat hypertension in the diabetic are ACE inhibitors, selected calcium channel blockers, alpha adrenengic blockers, and certain central alpha agonists. The only diuretics that should be used are indapamide and torsemide.
Notified cases of legionnaires’ disease in France in 2001
Authors: C Campese, B Decludt
Journal: Eurosurveillance (2002)

In 2001, 807 cases of Legionnaires' disease were reported to the Institut de veille sanitaire (French national public health centre). The incidence of the disease was 1.35 cases per 100,000 inhabitants, compared to a mean European incidence of 0,6 per 100,000. The median age was 59 years [16-97], the group aged more than 80 being the most affected. The sex ratio M/W was 3.1. The outcome of the disease was known in 69% of all cases, the case fatality ratio rating 19.9%. Among the contributing factors found in 558 cases, 11% had a cancer or blood disease, 12% received an immunosuppressant treatment, 10% were diabetic and 40% were smokers. In 2001, 13% (105/807) cases stayed in a hospital or a clinic during the incubation period, compared to 20% in 2000, and 11% were travel-associated.
XDR-TB transmission in London: Case management and contact tracing investigation assisted by early whole genome sequencing
Authors: Amber Arnold, Adam A. Witney, Stephania Vergnano, Anita Roche, Catherine A. Cosgrove, Angela Houston, Katherine A. Gould, Jason Hinds, Peter Riley, Derek Macallan, Philip D. Butcher, Tom S. Harrison
Journal: Journal of Infection (2016)
Clinical Characteristics and Risk Factors of Extensive Macular Atrophy with Pseudodrusen
Authors: Aymeric Douillard, Marie-Christine Picot, Cécile Delcourt, Annie Lacroux, Xavier Zanlonghi, Bernard Puech, Sabine Defoort-Dhelemmes, Isabelle Drumare, Elsa Jozefowicz, Béatrice Bocquet, Corinne Baudoin, Nour Al-Dain Marzouka, Sarah Perez-Roustit, Sophie Arsène, Valérie Gissot, François Devin, Carl Arndt, Benjamin Wolff, Martine Mauget-Faÿsse, Maddalena Quaranta, Thibault Mura, Dominique Deplanque, Hassiba Oubraham, Salomon Yves Cohen, Pierre Gastaud, Olivia Zambrowsky, Catherine Creuzot-Garcher, Saddek Mohand Saïd, Rocio Blanco Garavito, Eric Souied, José-Alain Sahel, Isabelle Audo, Christian Hamel, Isabelle Meunier
Journal: Ophthalmology (2016)
LP30 : Liver-directed allosteric inhibitors of acetyl-coa carboxylase favorably impact pathophysiology in the progression from nafld to nash and hepatocellular carcinoma, including hepatic steatosis, inflammation, and fibrosis
Authors: W.F. Westlin, H.J. Harwood, D.K. DePeralta, O. Moaven, L. Wei, J. Greenwood, S. Bhat, B.C. Fuchs, R. Kapeller, G. Harriman
Journal: Journal of Hepatology (2015)
The educational process as a treatment modality in a drug rehabilitation program
Authors: L Suchotliff, S Meyer
Journal: American Journal of Psychiatry (1975)

The authors describe an eductional program that is an integral part of a residential drug rehabilitation program. They believe that effective treatment of drug addiction must provide individuals with the opportunity to acquire skills that will make it easier for them to compete in the job market when they leave the program. They discuss how the educational process serves as a treatment modality that supplements and complements the other aspects of the therapeutic community.
A long non-coding RNA signature to improve prognosis prediction of gastric cancer
Authors: Xiaoqiang Zhu, Xianglong Tian, Chenyang Yu, Chaoqin Shen, Tingting Yan, Jie Hong, Zheng Wang, Jing-Yuan Fang, Haoyan Chen
Journal: Molecular Cancer (2016)

Increasing evidence suggests long non-coding RNAs (lncRNAs) are frequently aberrantly expressed in cancers, however, few related lncRNA signatures have been established for prediction of cancer prognosis. We aimed at developing alncRNA signature to improve prognosis prediction of gastric cancer (GC).Using a lncRNA-mining approach, we performed lncRNA expression profiling in large GC cohorts from Gene Expression Ominus (GEO), including GSE62254 data set (N = 300) and GSE15459 data set (N = 192). We established a set of 24-lncRNAs that were significantly associated with the disease free survival (DFS) in the test series.Based on this 24-lncRNA signature, the test series patients could be classified into high-risk or low-risk subgroup with significantly different DFS (HR = 1.19, 95 % CI = 1.13-1.25, P < 0.0001). The prognostic value of this 24-lncRNA signature was confirmed in the internal validation series and another external validation series, respectively. Further analysis revealed that the prognostic value of this signature was independent of lymph node ratio (LNR) and postoperative chemotherapy. Gene set enrichment analysis (GSEA) indicated that high risk score group was associated with several cancer recurrence and metastasis associated pathways.The identification of the prognostic lncRNAs indicates the potential roles of lncRNAs in GC biogenesis. Our results may provide an efficient classification tool for clinical prognosis evaluation of GC.
Case 7-1965
Authors: Arnold N. Weinberg, F. Daniel Foley
Journal: New England Journal of Medicine (1965)

Presentation of CaseA fifty-nine-year-old schizophrenic woman was admitted to the hospital after a fall.The patient had been committed to a state hospital thirty-nine years previously because of mental illness. Ten years before admission electric shock and insulin were given, and she was discharged to the care of her family one year later. For two years before entry she had a chronic cough and ate poorly, with a loss of considerable weight. During the four months before admission dyspnea, paroxysmal nocturnal dyspnea and edema developed, and she was intermittently febrile. Three days before entry she fell, striking her head . . .
PCM-03A COMPREHENSIVE PANEL OF PATIENT-DERIVED ORTHOTOPIC XENOGRAFT MOUSE MODELS OF MALIGNANT PEDIATRIC BRAIN TUMORS
Authors: Lin Qi, Mari Kogiso, Yuchen Du, Holly Lindsay, Huiyuan Zhang, Sibo Zhao, Frank K. Braun, Qin Shu, Litian Yu, Xiumei Zhao, Zhigang Liu, Yulun Huang, Laszlo Perlaky, Jack Su, Patricia Baxter, Adekunle Adesina, D. Will Parsons, Murali Chintagumpala, Xiao-Nan Li
Journal: Neuro-Oncology (2016)
<i>Tropheryma whippelii</i>
Authors: E J Fricker, T J McDonald
Journal: New England Journal of Medicine (1996)

Figure 1. A 46-year-old man presented with a 50-lb (23-kg) weight loss and diarrhea. An electron micrograph (Panel A, ×6913) of tissue from the small bowel showed numerous extracellular bacilli (Tropheryma whippelii; A), a phagosome containing bacilli (B) within a macrophage (M), and a neutrophil (N). Staining of the tissue with hematoxylin and eosin (Panel B, ×10) revealed clubbed epithelial villi (E) and foamy macrophages (FM). Periodic acid–Schiff staining (Panel C, ×40) showed clubbed villi, lipid droplets, and lamina propria packed with positive-staining macrophages.