Postsplenectomy Thrombocytosis
Authors: DONALD M. HAYES
Journal: Annals of Internal Medicine (1963)

Article1 February 1963Postsplenectomy ThrombocytosisDONALD M. HAYES, M.D., CHARLES L. SPURR, M.D., F.A.C.P., LUCILLE W. HUTAFF, M.D., F.A.C.P., JAMES A. SHEETS, M.D.DONALD M. HAYES, M.D.Search for more papers by this author, CHARLES L. SPURR, M.D., F.A.C.P.Search for more papers by this author, LUCILLE W. HUTAFF, M.D., F.A.C.P.Search for more papers by this author, JAMES A. SHEETS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-2-259 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPostsplenectomy thrombocytosis is a complication of splenectomy about which there is little published information. Our purpose is to review the literature concerning this problem, to present data from 3 cases encountered within the past 2 years, and to discuss how these data indicate that this entity should be better known.In 1923, Rosenthal (1) pointed out that there were 2 groups into which patients with "Banti's disease" could be divided. One is the thrombocytopenic group in whom platelets are diminished before splenectomy, followed by a transient rise and then a fall to normal values following splenectomy. The second group he...References1. ROSENTHAL N: Clinical and hematologic studies on Banti's disease. I. The blood platelet factor with reference to splenectomy. JAMA 84: 1887, 1923. CrossrefGoogle Scholar2. DAWBARNEARLAMEVANS RYFWH: The relation of the blood platelets to thrombosis after operation and parturition. J. Path. Bact. 31: 833, 1931. CrossrefGoogle Scholar3. KRUMBHAAR EB: The changes produced in the blood picture by removal of the normal mammalian spleen. Amer. J. Med. Sci. 184: 215, 1932. CrossrefGoogle Scholar4. WOLLSTEINKREIDEL MKV: Blood picture after splenectomy in children. Amer. J. Dis. Child. 51: 765, 1936. CrossrefGoogle Scholar5. DIAMOND LK: Indications for splenectomy in childhood. Amer. J. Surg. 39: 400, 1938. CrossrefGoogle Scholar6. ADAMS E: Postoperative thrombocytosis. Arch. Intern. Med. 73: 329, 1944. CrossrefGoogle Scholar7. SALTERSHERLOCK PPEC: Splenectomy, thrombocytosis, and venous thrombosis. Amer. Surg. 23: 549, 1957. MedlineGoogle Scholar8. SHARNOFF JG: Increased pulmonary megakaryocytes—probable role in postoperative thromboembolism. JAMA 169: 688, 1959. CrossrefMedlineGoogle Scholar9. LIPSONBAYRDWATKINS RLEDCH: The postsplenectomy blood picture. Amer. J. Clin. Path. 32: 526, 1959. CrossrefMedlineGoogle Scholar10. MEILLEURMEYERS PAMC: Thrombocytosis: a postsplenectomy complication in agnogenic myeloid metaplasia. Amer. J. Med. Sci. 241: 68, 1961. CrossrefMedlineGoogle Scholar11. BIGGSMACFARLANE RRG: Human Blood Coagulation and Its Disorders, 2d Ed., Blackwell Scientific Publications, Oxford, 1957, p. 175. Google Scholar12. SINGERMILLERDAMESHEK KEBW: Hematologic changes following splenectomy in man, with particular reference to target cells, hemolytic index, and lysolecithin. Amer. J. Med. Sci. 202: 171, 1941. CrossrefGoogle Scholar13. CRONKITEBONDFLIEDNERPAGLIAADAMIK EPVPTMDAER: Studies on the origin, production, and destruction of platelets, in Blood Platelets, Henry Ford Hospital Symposium, Little, Brown and Company, Boston, 1961. Google Scholar14. ODELLANDERSON TTB: Production and life span of platelets, in Proceedings of Conference on Kinetics of Cellular Proliferation in Hemopoietic Tissues, ed. by Stohlman, F. S., Grune & Stratton, Inc., New York, 1959, p. 278. Google Scholar15. ODELLTAUSCHEFURTH TTFGJ: Platelet life span as measured by transfusion of isotopically labeled platelets into rats. Acta Haemat. 13: 45, 1955. CrossrefMedlineGoogle Scholar16. GUNZ FW: Hemorrhagic thrombocythemia: a critical review. Blood 15: 706, 1960. CrossrefMedlineGoogle Scholar17. WASSERMAN LR: Polycythemia vera—its course and treatment: relation to myeloid metaplasia and leukemia. Bull. NY Acad. Med. 3: 343, 1954. Google Scholar18. QUICK AJ: Hemorrhagic Diseases, Lea and Febiger, Philadelphia, 1957, p. 252. Google Scholar19. SPAETBAUERMELAMED THSS: Hemorrhagic thrombocythemia, a blood coagulation disorder. Arch. Intern. Med. 98: 376, 1956. CrossrefGoogle Scholar20. KLEINFIORENTINO ER: Effects of varying concentrations of platelets and their lyophilized derivatives on generation of thromboplastin. Proc. Soc. Exp. Biol. Med. 94: 357, 1957. CrossrefMedlineGoogle Scholar21. HYUNDAWSONCUSTER BHEARP: Evaluation of thrombocythemia by the thromboplastin generation test. Amer. J. Clin. Path. 29: 539, 1958. CrossrefMedlineGoogle Scholar22. SPURRHAYES CLDM: Clinical observations on newer chemotherapeutic agents. Southern Med. J. 53: 1005, 1960. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Winston-Salem, North CarolinaFrom the Department of Medicine, The Bowman Gray School of Medicine of Wake Forest College and the North Carolina Baptist Hospital, Winston-Salem, North Carolina.Presented in part at the Annual North Carolina Regional Meeting of the American College of Physicians, Winston-Salem, North Carolina, December 7, 1961.This study was supported by grant CRTY-5035 from the National Cancer Institute, United States Public Health Service.Requests for reprints should be addressed to Donald M. Hayes, M.D., Department of Internal Medicine, Wake Forest College, The Bowman Gray School of Medicine, Winston-Salem 7, North Carolina. 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Recurrent arterial thromboembolism and death.REBOUND THROMBOCYTOSIS AFTER ALCOHOL ABUSE: A POSSIBLE FACTOR IN THE PATHOGENESIS OF THROMBOEMBOLIC DISEASEPostsplenectomy Thrombocythemia: An Unmasked Myeloproliferative DisorderNonatherosclerotic Causes of StrokeJONATHAN LEVINE, M.D., PHILLIP D. SWANSON, M.D.BIBLIOGRAPHYAcute Infantile Hemiplegia Associated with ThrombocytosisSPLENECTOMY IN HEMATOLOGIC DISEASESTHROMBO-EMBOLISM AND INCREASED PLATELET ADHESIVENESS IN POST-SPLENECTOMY THROMBOCYTOSISPersistent Post-Splenectomy Thrombocytosis and Thrombo-embolism: A Consequence of Continuing AnaemiaZur Frage einer depressorischen Knochenmarkwirkung „hypersplener” MilzenIndications for splenectomy in the pediatric patient 1 February 1963Volume 58, Issue 2Page: 259-267KeywordsBlood plasmaFallsHemolytic anemiaHospital medicineMedical servicesPlateletsSplenectomyThrombocytosis Issue Published: 1 February 1963 PDF downloadLoading ...