tbuckley/cabot-search huggingface dataset:
Effects of dexamethasone (Dex) pretreatment on toxicity and efficacy of carboplatin and gemcitabine (Carbo/Gem) in patients with non-small cell lung cancer (NSCLC)
Authors: M. Leggas, K. Kuo, G. Cloud, M. Li, H. Wang, R. Zhang, F. Robert, J. J. Rinehart
Journal: Journal of Clinical Oncology (2007)

18124 Background: Our preclinical data showed that treating mice with Dex 4 days prior to chemotherapy increased efficacy and decreased toxicity of Carbo/Gem in nude mice bearing human NSCLC by increasing drug concentration in tumors, and decreasing drug concentration in normal tissue without altering plasma pharmacokinetics (PK). Thus, we undertook a Phase I/II trial to determine the optimal dose of Dex, and the effect of Dex on Carbo/Gem plasma PK. Methods: Patients (n=30) with untreated, stage IV NSCLC and PS =2 received Gem, 1g/m2 days 1&amp;8, and Carbo, AUC 5.5 on day 1. Patients were randomized (1:2:2) to receive no Dex (arm 1), or Dex at 8 and 16 mg bid po 4 days before and on day 1 (arms 2 and 3). Dex was administered in courses 2, 3, and 4 (only) to allow course 1 vs course 2 intra-patient toxicity and Carbo/Gem plasma PK assessment. Plasma samples were analyzed by HPLC for Carbo/Gem. Plasma PK analysis was performed with NONMEM v5 using a 5-compatment or 2-compartment structural models for Gem and Carbo. Results: Patients in arms 1, 2, and 3 were similar in PS, age, gender, and histology. In arms 1, 2, and 3, patients completing 4 planned courses of therapy: 1/6, 6/12, 9/12; partial responses (RECIST): 2/6, 7/12, and 8/12. Hematologic toxicity in arms 1 (no Dex), 2, and 3 (Dex) was compared. Platelet nadirs (course2÷course1): 0.6±0.2, 3.77±2.0, 3.4±0.72 (p&lt;0.02); AGC nadirs: 1.1±0.3, 2.32±0.4, 4.95±1.04 (p&lt; 0.01); Change in median time to recovery from day 1 (course 2-course 1) of AGC to 1,500 mm3 in days: +9, -15, -19; Change in median time to recovery of platelets to 100,000 mm3: +5, -1, -1.5. Comparison of nadir AGC and platelets between courses 2, 3, and 4 consistently demonstrated superiority of arm 3 over arm 2. No significant differences in non-hematologic toxicities were seen between arms 1, 2 and 3. Gem and Carbo clearance values were not significantly different among arms or courses. Area under the time-concentration curves (course2÷course1): 0.91±0.18, 0.77±0.15, 0.80±0.16. Conclusions: Dex pretreatment appears to reduce toxicity and improve efficacy of Carbo/Gem in NSCLC patients, with arm 3&gt;2. These effects are not due to alteration of plasma PK since no significant decrease in chemotherapy exposure was observed in arms 2 and 3. [Table: see text]
PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis
Authors: Partha Mukhopadhyay, Béla Horváth, Mohanraj Rajesh, Zoltán V. Varga, Karim Gariani, Dongryeol Ryu, Zongxian Cao, Eileen Holovac, Ogyi Park, Zhou Zhou, Ming-Jiang Xu, Wei Wang, Grzegorz Godlewski, Janos Paloczi, Balazs Tamas Nemeth, Yuri Persidsky, Lucas Liaudet, György Haskó, Peter Bai, A. Hamid Boulares, Johan Auwerx, Bin Gao, Pal Pacher
Journal: Journal of Hepatology (2016)
3D Cell‐Printing: 3D Cell Printing of Functional Skeletal Muscle Constructs Using Skeletal Muscle‐Derived Bioink (Adv. Healthcare Mater. 20/2016)
Authors: Yeong‐Jin Choi, Taek Gyoung Kim, Jonghyeon Jeong, Hee‐Gyeong Yi, Ji Won Park, Woonbong Hwang, Dong‐Woo Cho
Journal: Advanced Healthcare Materials (2016)

On page 2636, Dong-Woo Cho and co-workers introduce a skeletal muscle-derived bioink with 3D cell printing technology that facilitates the fabrication of 3D functional muscle constructs. 3D cell printing technology can generate various types of constructs and cellular alignments in a controlled manner. The bioink retains the major ECM molecules that provide a microenvironment similar to that of native muscle and induce myogenesis in 3D cell-printed muscle constructs.
In vivo mapping of the effects of radiotherapy on neovascular permeability using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)
Authors: W. Ceelen, P. Smeets, N. van Damme, T. Boterberg, P. Demetter, M. El-Malt, P. Pattyn, M. Peeters
Journal: Journal of Clinical Oncology (2005)

3550 Background: Neoadjuvant therapy is an integral part of rectal cancer management. Prediction of response to radiotherapy (RT) is highly relevant for both further surgery and prognosis in these patients. In a rat colorectal cancer model, we studied the use of DCE-MRI with a new macromolecular rapid clearance contrast agent (P792) to visualize tumor vascular permeability as a surrogate marker for angiogenesis and evaluate the effect of RT. Methods: Male WAG/Rij rats were injected with 2x106 CC531 cells in the hind leg. Once the tumor reached a diameter of 1 cm, DCE-MRI with high temporal resolution was performed before and 5 days after 5x500 cGy of external RT. The DCE-MRI data were used to generate parametric tissue permeability maps of the endothelial transfer constant (Ktrans) according to the Tofts-Kermode two compartment mathematical model. Separate region of interest (ROI) analyses were performed of the entire tumor (T), periferal vascular rim (P) and tumor core (C). In order to differentiate permeability changes from flow and oxygenation effects of RT, fiber optic tissue pO2 and microcirculatory laser blood flow (LBF) histogram mapping was performed in each tumor before and after RT using a stepwise micromanipulator technique. Results: The biophysical properties of P792 allowed excellent discrimination between tumor and normal tissue. Mean Ktrans (ml/min/1000g tissue) value changes measured over all pixels in a ROI were as follows: T: 24.03 vs 5.47 (p<0.05); P: 29.7 vs 10.4 (p<0.05); and C: 8.65 vs 0.47 (p<0.05) before and after radiotherapy. Microcirculatory LBF (arbitrary units) decreased from 117.3 to 84.7 (p<0.001) after RT. All tumors were severely hypoxic with a mean tissue pO2 over a 4 mm trajectory of 3.5 mm Hg before and 5.6 mm Hg after RT (p<0.001). Conclusions: High temporal resolution DCE-MRI with P792 allows non-invasive imaging and quantification of neovascular permeability in this colorectal cancer model. Administration of RT significantly reduces permeability and microcirculatory flow. RT enhanced oxygenation, but all tumors remained severely hypoxic after radiotherapy. DCE-MRI could have an important role in therapy monitoring. No significant financial relationships to disclose.
MINI01.10: Diverse Populations may be Underrepresented in Community Lung Cancer Screening Programs
Authors: Bretta M. McCall, Candice L. Wilshire, Hannah E. Modin, Joelle T. Fathi, Christopher R. Gilbert, Brian Louie, Ralph W. Aye, Alexander S. Farivar, Eric Vallieres, Jed A. Gorden
Journal: Journal of Thoracic Oncology (2016)
TCT-60 1-year Clinical Outcomes of Absorb Bioresorbable Vascular Scaffold (BVS) in Diabetic and Non-Diabetic Patients: Patient-Level Pooled Analysis from the ABSORB Randomized Trials
Authors: Ariel Furer, Ori Ben-Yehuda, Bjorn Redfors, Patrick Serruys, Runlin Gao, Takeshi Kimura, Dean Kereiakes, Stephen Ellis, Weiying Zhao, Minh-Thien Vu, Yoshinobu Onuma, Gregg Stone
Journal: Journal of the American College of Cardiology (2016)
Single fasting plasma glucose measurement compared with 75 g oral glucose-tolerance test in prediction of adverse perinatal outcomes: a prospective cohort study from China
Authors: Songying Shen, Jinhua Lu, Lifang Zhang, Jianrong He, Weidong Li, Niannian Chen, Xingxuan Wen, Wanqing Xiao, Mingyang Yuan, Lan Qiu, Kar Keung Cheng, Huimin Xia, Ben Willem J Mol, Xiu Qiu
Journal: The Lancet (2016)
Timing and approaches in congenital cataract surgery: a randomised controlled trial
Authors: Weirong Chen, Erping Long, Jingjing Chen, Zhenzhen Liu, Zhuoling Lin, Qianzhong Cao, Xiaohang Wu, Qiwei Wang, Duoru Lin, Xiaoyan Li, Lixia Luo, Bo Qu, Haotian Lin, Yizhi Liu
Journal: The Lancet (2016)
TCT-67 Impact of the SYNTAX score in patients with diabetes and left-main and/or multivessel coronary disease: a pooled analysis of individual patient level data from the SYNTAX, PRECOMBAT and BEST trials
Authors: Rafael Cavalcante, Yohei Sotomi, Pannipa Suwannasom, Cheol Whan Lee, Jung-Min Ahn, ERHAN TENEKECIOGLU, Yaping Zeng, Carlos Collet, Yosuke Miyazaki, Yoshinobu Onuma, Seung-Jung Park, Patrick Serruys
Journal: Journal of the American College of Cardiology (2016)
Royal colleges issue list of 40 unnecessary interventions
Authors: Ingrid Torjesen
Journal: BMJ (2016)

The Academy of Medical Royal Colleges has issued a list of 40 tests, treatments, and procedures that it says are of little or no benefit to patients.1

The list has been created by the academy’s member royal colleges and faculties, with input from patient groups and the National Institute for Health and Care Excellence, and released to mark the launch of the academy’s Choosing Wisely campaign, which includes advice about treatments for doctors and patients.

The Choosing Wisely initiative aims to encourage doctors and patients to have a fully informed conversation about the risks and benefits of treatments and procedures before proceeding with them. It recommends that patients should always ask five key questions when seeking treatment: do I really need this test, treatment, or procedure; what are the risks or downsides; what are the possible side effects; are there simpler, safer options; and what will happen if …
TCT-831 Novel Thin Strut (100 μm) Ultra-High Molecular Weight PLLA Sirolimus-Eluting Bioresorbable Scaffold: A Comparative Preclinical Evaluation in Porcine Coronary Arteries
Authors: Andres Valencia, Pawel Gasior, Yanping Cheng, Jinggang Xia, Alex Estrada, Jenn McGregor, Kamal Ramzipoor, Chang Lee, Gerard Conditt, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2016)
Preparedness for Zika Virus Disease — New York City, 2016
Authors: Syra S. Madad, Joseph Masci, Nicholas V. Cagliuso, Machelle Allen
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

The rapid spread of Zika virus across the World Health Organization's Region of the Americas has had a direct effect on the U.S. health care delivery system. Hospitals in New York City (NYC) have been implementing prevention and response efforts consistent with CDC guidance. As of September 21, 2016, a total of 715 cases of laboratory-confirmed Zika virus disease had been diagnosed in New York state among travelers who returned from affected areas, their sexual contacts, or infants infected in utero. This represents the highest number of reported cases in any state to date, and underscores the importance of health care systems preparing to care for patients with possible Zika virus disease (1). Building upon a framework that was established in 2014 to screen patients for possible exposure to Ebola virus disease (Ebola), NYC Health + Hospitals,* the largest municipal health care delivery system in the United States, implemented a Zika Preparedness and Response Action Plan† (Zika Action Plan) to address the threat from Zika and ensure appropriate patient care. The plan developed by NYC Health + Hospitals includes universal travel screening, signage depicting areas with active Zika virus transmission, clinical and epidemiologic evaluation for possible Zika virus exposure, diagnostic testing for Zika virus infection and linking of infected patients to appropriate specialists, and education on Zika virus disease and preventive measures (e.g., avoiding travel to areas with active Zika virus transmission).
TCT-313 Incidence and Predictors of Very Late Major Adverse Cardiac Events After Metallic Stents: A Patient-Level Pooled Analysis from Seventeen Randomized Trials
Authors: Mahesh Madhavan, Ajay Kirtane, Bjorn Redfors, Philippe Généreux, Pieter Smits, Roxana Mehran, Rupa Parvataneni, Gregg Stone
Journal: Journal of the American College of Cardiology (2016)
TCT-778 Outcomes from the Chocolate BAR: a Large, Multi-Center, Prospective, Post-Market Study on use of the Chocolate Percutaneous Transluminal Angioplasty (PTA) Balloon
Authors: Georgios Bouras, Alexandra Lansky, John McClure, Mehdi Shishehbor, Michael Jaff, Prakash Makam, Sarah Johnson, Thomas Davis, Jihad Mustapha
Journal: Journal of the American College of Cardiology (2016)
TCT-118 Sex Differences in Coronary Angiography, Percutaneous Coronary Intervention, and Outcomes During Hospitalization After Out of Hospital Cardiac Arrest with Ventricular Fibrillation or Pulseless Ventricular Tachycardia
Authors: Nileshkumar Patel, Nish Patel, Shilpkumar Arora, Apurva Badheka, Abhishek Deshmukh, Carlos Alfonso, Eduardo DeMarchena, Mauricio Cohen, Deepak Bhatt, Robert J. Myerburg
Journal: Journal of the American College of Cardiology (2016)
TCT-685 Pre-existing Right Bundle-Branch Block Increases Risk of Death after Transcatheter Aortic Valve Implantation with a Balloon-Expandable Valve
Authors: Yusuke Watanabe, Ken Kozuma, Hirofumi Hioki, Hideyuki Kawashima, Yugo Nara, Makoto Nakashima, Fukuko Nagura, Akihisa Kataoka, Shirai Shinichi, Norio Tada, Motoharu Araki, Kensuke Takagi, Futoshi Yamanaka, Masanori Yamamoto, Kentaro Hayashida
Journal: Journal of the American College of Cardiology (2016)
TCT-12 Real World Utilization of Computed Tomography Derived Fractional Flow Reserve: Single Center Initial Experience in the United States
Authors: Anas Fares, Ahmad Alkhalil, Bradley Martin, Amer Alaiti, Fahd Nadeem, Prashanth Thakker, Daniel Simon, Robert Gilkeson, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2016)
Clonus Associated with Tropical Spastic Paraparesis
Authors: Mateus S do Rosário
Journal: New England Journal of Medicine (2016)

A 53-year-old woman with tropical spastic paraparesis reported several months of worsening weakness of the legs and feet. On examination, she had severe spasticity and weakness of both legs and feet, bilateral Babinski sign, and bilateral patellar clonus, shown in a video.
Effectiveness and impact of a reduced infant schedule of 4CMenB vaccine against group B meningococcal disease in England: a national observational cohort study
Authors: Sydel R Parikh, Nick J Andrews, Kazim Beebeejaun, Helen Campbell, Sonia Ribeiro, Charlotte Ward, Joanne M White, Ray Borrow, Mary E Ramsay, Shamez N Ladhani
Journal: The Lancet (2016)
TCT-408 Thirty-day Outcome Following Polymeric Bioresorbable Scaffold Implantation in 347 STEMI Patients Enrolled in the Multicenter “Registro Absorb Italiano” (RAI Registry)
Authors: Alfonso Ielasi, Elisabetta Moscarella, Bruno Loi, Bernardo Cortese, Paolo Calabro', Giuseppe Tarantini, Roberto Gistri, Francesco Pisano, Pietro Mazzarotto, Gabriele Gabrielli, Giampaolo Pasquetto, Leonardo Misuraca, Valerio Lucci, Gabriele Tumminello, Luciano Moretti, Maurizio Ferrario, Alessandro Colombo, Alessandro Durante, Massimo Fineschi, Annamaria Nicolino, Davide Piraino, Attilio Varricchio, Maurizio Tespili, Donatella Corrado, Giuseppe Steffenino
Journal: Journal of the American College of Cardiology (2016)
Gene Amplifications In 84 Patients With Acute Myeloid Leukemia and 31 Patients With Myelodysplastic Syndrome Investigated By Array CGH
Authors: Andreas Roller, Simone Weber, Alexander Kohlmann, Melanie Zenger, Marita Staller, Wolfgang Kern, Susanne Schnittger, Torsten Haferlach, Claudia Haferlach
Journal: Blood (2013)
TCT-442 3-year clinical outcomes of complete versus partial stent fracture after percutaneous coronary intervention with second-generation drug-eluting stent
Authors: Dong-Kie Kim, Ji-Hoon Jang, Yun Seok Song, Guang-Won Seo, Pil Sang Song, Ki-Hun Kim, Sang-Hoon Seol, Doo-Il Kim
Journal: Journal of the American College of Cardiology (2016)
Platelets from Patients with Myocardial Infarction Can Activate T Cells in Vitro
Authors: Elena E. Solomou, Vasilios Gizas, Theodora Babali, Angelos Perperis, Evgenia Verigou, Periklis Ntavlouros, Charalambos Gogos, Dimitrios Alexopoulos
Journal: Blood (2015)
TCT-844 Safety and Feasibility of Sirolimus Eluting Bioresorbable Stents in Porcine Renal Arteries – 90-Day Angiographic and OCT study in Normal Swine
Authors: Ariel Furer, Pawel Gasior, Jenn McGregor, Taylor Palmieri, Gerard Conditt, Juan Granada, Greg Kaluza
Journal: Journal of the American College of Cardiology (2016)
TCT-325 The effects of types of guidewires and pressure applied during stent implantation in the main vessel on the incidence of damage to coronary guidewires during angioplasty of coronary bifurcation lesions - Wide Beast study
Authors: Piotr Kwiatkowski, Edyta Sutkowska, Jerzy Malachowski, Wioletta Jakubas-Kwiatkowska, Slawomir Golebiewski, Robert Gil
Journal: Journal of the American College of Cardiology (2016)
TCT-319 Side Branch Mortality Score for Prediction of Five Year Mortality After Provisional Side Branch Coronary Bifurcation Stenting – a New Tool Based on Intracoronary Electrocardiogram (iECG) From iECG and Myonecrosis After Bifurcation Stenting (COSIBRIA&amp;CO) (ClinicalTrials.gov Identifier:NCT01268228)
Authors: Dobrin Vassilev, Kiril Karamfiloff, Liubomir Dosev, Jivka Stoykova, Vladimir Naunov, Ralitsa Pancheva, Galina Zlatancheva, Monika Shumkova, Dobrin Svinarov, Adelina Cakova, Gianluca Rigatelli, Robert Gil
Journal: Journal of the American College of Cardiology (2016)
Risk Factors for Tumor Lysis Syndrome (TLS) In Patients with Chronic Lymphocytic Leukemia (CLL) Treated with the Cyclin Dependent Kinase Inhibitor, Flavopiridol.
Authors: Kristie A. Blum, Amy S. Ruppert, Jennifer A. Woyach, Jeffrey A. Jones, Leslie Andritsos, Joseph M. Flynn, Brad Rovin, Miguel Villalona-Calero, Jia Ji, Mitchell Phelps, Amy J. Johnson, Michael R. Grever, John C. Byrd
Journal: Blood (2010)
Prognostic value of age in nasopharyngeal carcinoma patients: A single institution analysis
Authors: N. L. Downing, P. Wong, D. Petrik, W. Hara, Q. Le
Journal: Journal of Clinical Oncology (2007)

6080 Background: Nasopharyngeal carcinoma (NPC) has a bimodal age distribution with peaks at 15–25 and 40–50 years of age, though it is unclear if the prognosis differs significantly between the two age groups. Here, we compare treatment outcomes between two age groups of patients treated at a single institution. Methods: We retrospectively analyzed the data of 99 NPC patients who received definitive treatment at our institution between March 1985 and June 2004. All patients received a median dose of 66 Gy of external beam radiation therapy and 70% received either concurrent or induction chemotherapy. We compared patient, tumor, and treatment characteristics as well as treatment outcomes in juvenile patients (age = 25 years at diagnosis), versus adult patients (age &gt; 25 years at diagnosis). Survival curves were estimated by the Kaplan-Meier method. Results: There was a significant difference in the ethnic composition between the age groups, with more Asians and fewer Whites and Hispanics in the adult group (see table ). Also, there was a significant difference between the groups in the proportion of patients receiving chemotherapy, especially induction chemotherapy (see table ). There was no difference in the distribution of tumor stage and WHO histology between the two age groups. At a median follow-up for all patients of 42 months (range 4 to 234), there were no statistically significant differences in treatment outcomes between the two age groups although the survival data numerically favored the juvenile patients (see table ). Conclusions: Although there were significant differences in racial distributions and treatment characteristics between the two age groups, treatment outcomes were similar. Aggressive treatment with radiotherapy and chemotherapy resulted in excellent outcomes for both patient populations. No significant financial relationships to disclose. [Table: see text]
Co-Morbidity and Disease Status at the Time of Transplant Predict Outcome Following Allogeneic Haematopoietic Stem Cell Transplantation (HSCT) for Poor Risk Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukaemia (AML).
Authors: Wendy Ingram, Zi Y. Lim, Michelle Kenyon, Stephen Devereux, Antonio Pagliuca, Aloysius Y.L. Ho, Mufti Ghulam
Journal: Blood (2006)
Public may accept national insurance rise to boost NHS funding, say experts
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The general public could be willing to accept a rise in their national insurance contributions if specifically earmarked for the NHS, experts have told peers.

Peers on the House of Lords committee for long term sustainability of the NHS quizzed witnesses during an evidence session on 25 October about how public support for NHS funding was matched by a willingness to pay for it and how.

They asked how politicians could most easily boost NHS funding, such as by introducing a publicly acceptable tax rise or a hike in national insurance contributions.

Ben Page, chief executive of the market research company Ipsos MORI, giving evidence, said, “Some sort …
A replication-defective human cytomegalovirus vaccine for prevention of congenital infection
Authors: Dai Wang, Daniel C. Freed, Xi He, Fengsheng Li, Aimin Tang, Kara S. Cox, Sheri A. Dubey, Suzanne Cole, Muneeswara Babu Medi, Yaping Liu, Jingyuan Xu, Zhi-Qiang Zhang, Adam C. Finnefrock, Liping Song, Amy S. Espeseth, John W. Shiver, Danilo R. Casimiro, Tong-Ming Fu
Journal: Science Translational Medicine (2016)

A new replication-defective human cytomegalovirus vaccine shows promise in protecting against this dangerous virus that can cause severe neurodevelopmental defects in babies.
Safety-Net Hospitals Care
Authors: Gerard M. Doherty
Journal: JAMA Surgery (2016)

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NHS will not deliver improvements without extra cash, MPs tell Chancellor
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The NHS in England will not be able to deliver the expected transformation as set out in the NHS Five Year Forward View1 without more money, MPs have told the Chancellor, Philip Hammond.

MPs on the parliamentary health committee took the unusual step of writing directly to the Chancellor on 31 October with a public letter that set out their concerns over pressures on the NHS, even before they published a report from their inquiry into the state of NHS finances.2

“We write as members of the health committee to express our concern that the extent of this pressure is not sufficiently recognised by the government,” they said in the letter, saying that they needed to alert the Chancellor to …
TCT-467 Comparison biolimus- and everolimus-eluting stents in patients with small vessels disease. Five year follow-up from the COMPARE II trial
Authors: Valeria Paradies, George Vlachojannis, Sjoerd H. Hofma, Mario Togni, Nicolas Vazquez, Mariano Valdes, Vassilis Voudris, ton slagboom, Jean-Jacques Goy, Andre Vuilliomenet, Antonio Serra, Ramiro Trillo, Peter Den Heijer, Martin van der Ent, Pieter Smits
Journal: Journal of the American College of Cardiology (2016)
TCT-816 Trend of Utilization &amp; Procedural Outcomes of Endomyocardial Biopsy in United States: A Nationwide Inpatient Sample Based Study
Authors: None alok saurav, Aiman Smer, Abhilash Akinapelli, Arun Kanmanthareddy, Muhammad Azzouz, Manu Kaushik, Himanshu Agarwal, Michael White, Venkata M. Alla, Claire C. Hunter, Syed Mohiuddin, Michael Delcore, Aryan Mooss, Dennis Esterbrooks
Journal: Journal of the American College of Cardiology (2016)