tbuckley/cabot-search huggingface dataset:
AB0353 Knee Arthroplasty Results in Rheumatoid Arthritis Patients with Secondary Gonarthrosis
Authors: I. Akhtyamov, S. Lapshina, L. Myasoutova, I. Gilmutdinov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Endoprosthesis is an effective method of pain relief and can improve knee function in patients with rheumatoid arthritis (RA). There remains the question of RA drug therapy in the perioperative period <h3>Objectives</h3> To review the results of knee arthroplasty depending on the initial activity of the disease. <h3>Methods</h3> Knee replacement was done 54 RA patients (48 women, 6 men), mean age 49, 8±16,14 years. At the time of the operation duration of the disease was 12,79±6,18 years, high activity (DAS28) - in 26%, moderate - in 55.5%, low - 18.5% of patients. 44 (81.5%) pts continued to take basic anti-rheumatic drugs (DMARDs), 22 (40.8%) pts received steroids, including in combination with DMARDs - 10 (18.6%). Before the operation, and after the 6 months estimated joint pain (VAS), disease activity - DAS28, functional capacity index HAQ were evaluated. In 28 patients the same parameters were assessed after 12 months. <h3>Results</h3> Decrease in pain intensity on the VAS was observed in the first month after knee arthroplasty, after 6 months the pain (VAS) decreased almost to 31.9 mm (p&lt;0.05). Disease activity decreased with HAQ index 1,68±0,94 to 1,15±0,73 (p&lt;0, 05). After 12 months, VAS was 25,4±11,8 mm, HAQ - 1,06±0,63. 6 months after surgery evaluation showed that VAS in patients treated with corticosteroids (n=22) was - 44,2±16,2 mm, receiving DMARDs without corticosteroids (n=32) -35,4±12,1 mm (p&lt;0.05), after 12 months VAS was 30,8±10,6 mm and 21,3±9,6 mm (p&lt;0.05), respectively, in groups. Significantly (p&lt;0.05) was observed than the positive dynamics in relation to the functional capacity of patients in the group receiving DMARDs with corticosteroids (HAQ 6 months -0,98±0,64, 12 months- 0,89±0,56) compared with patients receiving basic therapy without corticosteroids (HAQ 6 months -1,23±0,69, 12 months- 1,14±0,61) <h3>Conclusions</h3> Knee joint arthroplasty is an effective method to improve functional capacity, pain relief in gonarthrosis and reduces inflammatory activity. Joint function after surgery and in the remote period is better for patients receiving DMARDs compared to patients receiving corticosteroids. <h3>Disclosure of Interest</h3> None declared
Radionuclide imaging in bilateral os trigonum syndrome in a young athlete.
Authors: M Minoves, A Company, J Ardevol, R B Matas, J M Costansa, J Setoain, F M Domenech-Torné
Journal: Clinical Nuclear Medicine (2001)

MINOVES, MONTSE M.D.; COMPANY, ANA M.D.; ARDEVOL, JORGE M.D.; BALIUS MATAS, RAMON M.D.; COSTANSA, JOSE M. M.D.; SETOAIN, JORGE M.D.; DOMENECH-TORNÉ, FRANCISCO M. M.D. Author Information
SAT0384 Multireader Reliability Using Us in Salivary Glands: An International Web Exercice to Evaluate a New Us Scoring (NUSC) in Primary Sjogren Syndrome
Authors: S. Jousse, E. Nowak, E. Theander, A. Hocevar, M. Jonsson, V. Milic, A. Visink, A. Saraux, S.J. Bowman, V. Devauchelle-Pensec, J. Rout, J. Brown, J. Fradin, N. Luciano, M. Carotti, A. Carr, B. Fisher
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Ultrasonography (US) has been shown to be a sensitive tool to diagnose major salivary gland echotexture abnormalities in primary Sjögren9s syndrome (pSS). <h3>Objectives</h3> The purpose of this study was [1] to assess definitions of the different ultrasonographic components of the salivary glands and [2] to study the reliability of these definitions on static images with an international web exercice. <h3>Methods</h3> [1]The consensus exercice about definitions was done and discussed between 12 experts on the field of US pSS during 3 annual meetings. All experts were part of the US-pSS study group. [2]Using these preliminary definitions, a reliability exercice was done on static images. A centre (Brest- France) was in charge to send to the participants different representative US images collection of the agreed elementary lesions.30 parotid glands images and 30 submandibular glands images were sent to the experts by mail.They were asked to score each components of each glands in standardized file. Two rounds of exercicewere performed in order to obtain intra and inter reliability. The first round was in January 2014 and the second round was in March 2014. Inter and intra-observer agreements were estimated using the kappa index considering binary variables (agreements are almost perfect k:0.81 to 1.0; substantial: 0.61 to 0.8, moderate: 0.41 to 0.6, fair: 0.21 to 0.4, poor: -1.0 to 0.2). <h3>Results</h3> All experts were trained for US of salivary gland with at least 5 years of experience. We obtained definitions about 8 different components evaluating the abnormal parenchyma (echogenicity, homogenicity, presence or absence of hyperechoic bands, number of hypoechoic ares, and location of hypoechoic areas, lymph nodes, presence or absence of calcifications, visualisation of posterior border) on salivary glands in pSS patients. Results of the reliability web exercise is shown on table 1. Without practical training session, we showed good results concerning the intra and inter observer reliabilities applying these definitions on US parotid gland and submandibular glands, particularly in taking homogeneity as the main important item in this definition. Reliabilities for calcifications and posterior band were low. <h3>Conclusions</h3> This is the first consensus-based US definitions on salivary glands and its elementary components. These first results of the reliability exercice on static images without any training showed good results and permit to apply these preliminary definitions in routine practice and for further studies on pSS patients. <h3>Disclosure of Interest</h3> None declared
The Relative Activity of Xanthine Dehydrogenase, Catalase, and Amylase in Normal and Cancerous Hepatic Tissues of the Rat
Authors: Jesse P. Greenstein, Wendell V. Jenrette, Julius White
Journal: JNCI Journal of the National Cancer Institute (1941)

The Relative Activity of Xanthine Dehydrogenase, Catalase, and Amylase in Normal and Cancerous Hepatic Tissues of the Rat Jesse P. Greenstein, Jesse P. Greenstein research fellow Search for other works by this author on: Oxford Academic PubMed Google Scholar Wendell V. Jenrette, Wendell V. Jenrette junior physiologist Search for other works by this author on: Oxford Academic PubMed Google Scholar Julius White Julius White research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 2, Issue 1, August 1941, Pages 17–22, https://doi.org/10.1093/jnci/2.1.17 Published: 01 August 1941
Damage Induced in Sarcoma 37 with Chemical Agents. VI. Biphenyl, Fluorene, Phenanthrene, and Tropolone Derivatives
Authors: J. Leiter, J. L. Hartwell, J. S. Kahler, I. Kline, M. J. Shear
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Damage Induced in Sarcoma 37 with Chemical Agents. VI. Biphenyl, Fluorene, Phenanthrene, and Tropolone Derivatives Get access J. Leiter, J. Leiter Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. Hartwell, J. L. Hartwell Search for other works by this author on: Oxford Academic PubMed Google Scholar J. S. Kahler, J. S. Kahler Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Kline, I. Kline Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Shear M. J. Shear Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 2, October 1953, Pages 365–374, https://doi.org/10.1093/jnci/14.2.365 Published: 01 October 1953 Article history Received: 21 May 1953 Published: 01 October 1953
Effect of tricyclic antidepressants on the dexamethasone suppression test
Authors: J D Amsterdam, A Winokur, S Caroff
Journal: American Journal of Psychiatry (1981)

Twelve depressed outpatients were studied to determine if tricyclic antidepressants affect the dexamethasone suppression test (DST). The authors administered the DST to patients while they were drug free and 3 weeks after they had taken tricyclics. The difference between tests was not significant.
Increased expression of AT-1/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation
Authors: Rikki Hullinger, Mi Li, Jingxin Wang, Yajing Peng, James A. Dowell, Ewa Bomba-Warczak, Heather A. Mitchell, Corinna Burger, Edwin R. Chapman, John M. Denu, Lingjun Li, Luigi Puglielli
Journal: The Journal of Experimental Medicine (2016)

The import of acetyl-CoA into the lumen of the endoplasmic reticulum (ER) by AT-1/SLC33A1 regulates Nε-lysine acetylation of ER-resident and -transiting proteins. Specifically, lysine acetylation within the ER appears to influence the efficiency of the secretory pathway by affecting ER-mediated quality control. Mutations or duplications in AT-1/SLC33A1 have been linked to diseases such as familial spastic paraplegia, developmental delay with premature death, and autism spectrum disorder with intellectual disability. In this study, we generated an AT-1 Tg mouse model that selectively overexpresses human AT-1 in neurons. These animals demonstrate cognitive deficits, autistic-like social behavior, aberrations in synaptic plasticity, an increased number of dendritic spines and branches, and widespread proteomic changes. We also found that AT-1 activity regulates acetyl-CoA flux, causing epigenetic modulation of the histone epitope H3K27 and mitochondrial adaptation. In conclusion, our results indicate that increased expression of AT-1 can cause an autistic-like phenotype by affecting key neuronal metabolic pathways.
Symptom patterns associated with posttraumatic stress disorder among Vietnam veterans exposed to war trauma
Authors: R S Laufer, E Brett, M S Gallops
Journal: American Journal of Psychiatry (1985)

The authors tested whether the relationship between traumatic stress and posttraumatic stress disorder is captured more accurately by aggregating symptoms, as in DSM-III, or differentiating them into the subtypes of denial and reexperiencing. Their findings indicate that distinguishing between the responses of denial and reexperiencing is an alternative and potentially more useful approach for understanding posttraumatic stress disorder and its origins in war trauma than the comprehensive model proposed in DSM-III. The analysis suggests that biases in the current model of posttraumatic stress disorder may lead to underestimation of its prevalence. The authors conclude that reconsideration of what constitutes the disorder is warranted.
Damage Induced in Sarcoma 37 With Chemical Agents. V. Derivatives of Colchicine and Isocolchicine
Authors: J LEITER, J L HARTWELL, G E ULLYOT, M J SHEAR
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Damage Induced in Sarcoma 37 With Chemical Agents. V. Derivatives of Colchicine and Isocolchicine Get access J. Leiter, J. Leiter Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. Hartwell, J. L. Hartwell Search for other works by this author on: Oxford Academic PubMed Google Scholar G. E. Ullyot, G. E. Ullyot Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Shear M. J. Shear Laboratory of Chemical Pharmacology, National Cancer Institute2Bethesda, Md.Smith, Kline and French Laboratories, Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 5, April 1953, Pages 1201–1211, https://doi.org/10.1093/jnci/13.5.1201 Published: 01 April 1953 Article history Received: 22 October 1952 Published: 01 April 1953
PTU-136 Evaluation of speech and language therapy involvement in enhanced recovery post transhiatal oesophagectomy
Authors: CM Iezzi, JA Gossage, AR Davies, SK Archer
Journal: Gut (2015)

<h3>Introduction</h3> Patients who have undergone a transhiatal oesophagectomy (THO) are at risk of pharyngeal dysphagia and subsequent aspiration due to potential disruption in deglutitive biomechanics and/or neuropraxic injury to the recurrent laryngeal nerve. An evaluation was conducted of a new multidisciplinary enhanced recovery pathway (ERP) where all patients undergoing oesophagectomy with cervical anastomosis are seen both pre and post operatively by Speech and Language Therapy (SLT). <h3>Method</h3> All patients undergoing THO are provided with pre operative counselling and assessment to exclude pre morbid pharyngeal dysphagia. A clinical exam is conducted on day two post surgery and an SLT assisted water soluble swallow (WSS) is conducted on day three, enabling evaluation of deglutitive biomechanics, effectiveness of postural strategies in eliminating aspiration, in conjunction with assessment of anastomic integrity. Data on all patients who underwent THO between February 2014–February 2015 were collected to evaluate SLT intervention, incidence of pharyngeal dysphagia and patient outcomes using the Functional Oral Intake Scale (FOIS). <h3>Results</h3> 42 patients underwent THO. No patients had pre-morbid pharyngeal dysphagia. Post operatively 62% (n = 26) of patients presented with pharyngeal dysphagia on radiological examination with reduced hyolaryngeal excursion, reduced epiglottic deflection and opening of the upper oesophageal sphincter. 38.1% (n = 16) patients were identified at bedside assessment as high risk of aspiration and pharyngeal dysphagia was confirmed on WSS. In 100% of these (n = 16) no aspiration occurred when a chin tuck strategy was recommended at onset of WSS. A further 10 patients aspirated on WSS; a chin tuck strategy was recommended and this was effective in eliminating aspiration in 80% (n = 8). All patients were able to commence sips of clear fluid on day three if anastomotic leak was excluded despite pharyngeal dysphagia and aspiration risk with implementation of postural techniques. Overall, 90.5% (n = 38) of patients were tolerating oral intake at time of discharge (FOIS score &gt; 6). Four patients with anastomotic leaks were excluded from outcome measures. <h3>Conclusion</h3> Results suggest that involvement of SLT in ERP helps identify patients at risk of aspiration and introduction of strategies e.g. chin tuck can eliminate aspiration which may improve patient care. Further research is indicated to determine the effect of SLT input on patient outcomes. <h3>Disclosure of interest</h3> None Declared.
Unilateral Absence of Pulmonary Perfusion in Swyer-James Syndrome
Authors: PINAR ÖZGEN KIRATLI, MELTEM ÇAĞLAR, M. FANİ BOZKURT
Journal: Clinical Nuclear Medicine (1999)

Swyer-James syndrome is a rare disorder, usually affecting children after viral bronchitis. It is generally discovered on a chest radiograph as increased translucency involving one hemithorax because of diminished vascular markings. Bronchoscopy does not reveal obstruction, but extensive bronchitis or bronchiolitis may be observed on biopsy. The airways are normal in number, but mainly the pulmonary artery on the affected side is hypoplastic. Patency of the pulmonary artery observed on angiography differentiates this disorder from other types of pulmonary artery stenosis or atresia. The authors present a case of Swyer-James syndrome for which lung scintigraphy revealed reduced ventilation and perfusion on the affected side.
PWE-238 The prevalence of upper limb temperature dissociation in subgroups of FGID patients
Authors: KJ Etherson, C Emmett, P Syme, Y Yiannakou
Journal: Gut (2015)

<h3>Introduction</h3> Upper limb temperature dissociation has been demonstrated to exist in a prevalence of approximately 72% of FGID patients in our clinic, and in approximately 34% of controls. The prevalence of temperature dissociation in the subgroups of FGIDs are unknown. <h3>Aims</h3> To assess the prevalence of upper limb temperature dissociation in FGID subgroups and compare against an expected prevalence previously demonstrated in controls. <h3>Method</h3> Clinic attenders with a FGID diagnosis from a specialist tertiary clinic were sequentially invited to undertake the temperature sensation test. This comprised holding a bag of ice in both hands for 5 s and stating if they perceived the temperature to be either unilaterally colder or bilaterally equally cold. Unilaterally colder was considered to be evidence of upper limb temperature sensory dissociation. The actual percentage prevalence in each FGID subgroup was tested against an expected prevalence of 34.5% using a CHI-squared test with Fisher’s correction where applicable. <h3>Results</h3> Temperature sensory dissociation in the upper limbs was prevalent in most patients with FGIDs: 120/173 in the overall cohort (69%) [P &lt; 0.0001], 79/109 with functional constipation (72.5%) [P &lt; 0.0001], 10/13 with IBS-C (76.9%) [P = 0.001], 6/7 with IBS-D (85.7%) [P = 0.004], 7/10 with IBS-A (70%) [P = 0.018], 9/14 with gastropareisis (64.3%) [P = 0.018], 8/10 with functional vomiting (80%) [P = 0.002], and 6/9 with non-ulcer dyspepsia (67%) [P = 0.04]. There appeared to be no significant difference in patients with functional abdominal pain 7/14 (50%), and the rarer FGID subgroups were of an insufficiently small size to analyse. <h3>Conclusion</h3> Upper limb temperature sensory dissociation appears to be significantly more prevalent in most subgroups of the FGIDs. This may imply a connexion with a central autonomic aetiology for these conditions. These results are an interesting observation from our clinic but are likely to be limited by inherent methodological biases in the data collection. Further investigation of the prevalence of temperature dissociation is required in both patients and controls in order to validate these findings. <h3>Disclosure of interest</h3> None Declared.
PTH-215 Trace elements and vitamin levels in long-term home parenteral nutrition paediatric patients
Authors: R Núñez-Ramos, S Gallego, D Gayda-Pimlott, S Macdonald, J Koeglmeier, S Hill
Journal: Gut (2015)

<h3>Introduction</h3> Parenteral Nutrition (PN) is lifesaving therapy for children with intestinal failure (IF). Long-term home PN patients depend on commercially prepared intravenous multivitamin and trace element (TE) formulations. Patients should have regular assessment of micronutrient and vitamin status to avoid deficiencies. Our aim is to analyse micronutrient levels in our home PN cohort. <h3>Method</h3> We performed a retrospective review including children with IF who had been on home PN for at least 1 year. Demographic and clinical data were collected, including serum concentration of copper, selenium, iron, zinc, vitamin A, E, D, B12, folate and ferritin. Patients were categorised as deficient or normal, based on the mean value assessed in the last 6 months. Deficiencies were defined according to our laboratory reference range. The most commonly used TE, fat-soluble vitamins and water-soluble vitamins supplementation formulations were Peditrace®, Vitalipid® and Solivito®, prescribed according to ESPGHAN<sup>1</sup>guidelines, with adjustments as needed depending on each patient’s requirement. Micronutrient enteral supplementation was also recorded. <h3>Results</h3> 30 patients (16 male), median age 7.65 years (2.18–16.71), were included. The indications for home PN were gastrointestinal motility disorders (11 patients), short bowel syndrome (SBS, 8 cases), congenital enteropathies (6 cases), eosinophilic enteropathies (3 cases) and protein-losing enteropathy (2 cases). Median time on home PN was 3.85 years (0.67–12.08), ranging from 2 to 7 days a week, ussually infused over 12 h overnight. Twenty-two patients (73.3%) had at least one TE deficiency, 43.3% (13 patients) had at least one vitamin deficiency, and 26.7% (8 patients) had multiple micronutrient dificiencies. The most common micronutrient deficiencies identified were copper (46.7%), vitamin A (43.3%), selenium (20%), ferritin (20%) and zinc (10%). The higher rates of TE deficiencies were found among patientes with diagnosis of congenital enteropathies (83.3%) and SBS (75%). No morbidity associated with these deficiencies was observed. Vitamin E, D, B12 and folate levels were all normal. Eight patients were receiving enteral vitamin supplementation in addition to PN vitamins. <h3>Conclusion</h3> Although laboratory results outside the normal range were common in children with IF on home PN, there were no significant clinical abnormalities. The most frequent findings were suboptimal copper, vitamin A, selenium and ferritin levels. Our results emphasise the critical importance of routine surveillance of TE and vitamin levels and the need to prescribe home PN according to individual requirements. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Koletzko B, <i>et al</i>. Pediatr Gastroenterol Nutr. 2005;41
A follow-up of 78 patients with Gilles de la Tourette's syndrome
Authors: R D Bruun, A K Shapiro, E Shapiro, R Sweet, H Wayne, G E Solomon
Journal: American Journal of Psychiatry (1976)

The authors conducted a follow-up study of 78 patients with Gilles de la Tourette's syndrome. Four of the patients were in spontaneous remission; 59 patients taking haloperidol showed an average improvement of 79.3% and the remaining patients, 3 of whom were taking medication other than haloperidol and 12 of whom were not taking any medication, showed an average improvement of 24.7%. Side effects were the main cause of discontinuing haloperidol. The authors found that response to haloperidol was unrelated to family history of tics, age at onset, type or severity of symptoms, or signs of organicity.
The solitary thyroid nodule
Authors: C S Sinnatamby, D Attygalle, H K Fernando
Journal: JAMA (1980)

<h3>To the Editor.—</h3> We share the concern and opinion expressed by Blum and Rothschild (1980;243:242) in their article on suppressive therapy for the thyroid nodule. We have previously reported that clinical differentiation of thyroid cancer from benign goiter is satisfactory (1962;181:179). In a double-blind study in which placebo and triiodothyronine (T<sub>3</sub>) were compared, we have shown that the regression of goiter could be achieved by T<sub>3</sub>at a significantly higher rate than the spontaneous regression by placebo (46% vs 9%,<i>P</i>&lt;.001) (1963;185:29). In another randomized doubleblind study, we have also demonstrated that both T<sub>3</sub>and thyroxine (T<sub>4</sub>) were effective in shrinking goiters.<sup>1</sup>However, we found that T<sub>3</sub>achieves significantly better results than T<sub>4</sub>(73% vs 49%,<i>P</i>&lt;.025) and that a modest dose of thyroactive substances (50 μg per day for T<sub>3</sub>and 0.2 mg per day for T<sub>4</sub>) is
The value of sentinel lymph node biopsy in Merkel cell carcinoma
Authors: R. Russell-Jones
Journal: British Journal of Dermatology (2016)

The review of sentinel lymph-node biopsy (SLNB) in 721 patients with Merkel Cell Carcinoma (MCC) by Gunaratne and co-workers (1) is a valuable addition to the literature, but reflects many of the dilemmas surrounding the use of SLNB in malignant melanoma (2). Thus it is impossible to draw any conclusions from this review as to whether SLNB followed by completion lymphadenectomy in positive cases confers any survival advantage over observation, as no randomized trial has been performed in patients with MCC, and retrospective comparisons are invalid for the reasons pointed out by the authors.

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