tbuckley/cabot-search huggingface dataset:
Abstract 2454: Targeting the translational enhancer complex MCT-1:DenR to disrupt NHL survival
Authors: Sean D. Stowe, Michael C. Cavalier, Raquel Godoy-Ruiz, Kristen J. Varney, Paul T. Wilder, Ronald B. Gartenhaus, David J. Weber
Journal: Cancer Research (2015)

Abstract Despite the vast number of therapeutic advances that have been made, Non-Hodgkin Lymphoma (NHL) remains a leading cause of cancer-related deaths in the United States. In order to increase the NHL cure rate, new targeted options are needed. One such option that has been the focus of much recent interest is the post-transcriptional regulation in anti-apoptotic phenotypes of NHL, particularly the translational enhancer complex of MCT-1 and DENR. Involved in translation initiation and ribosomal recycling for transcripts regulated by 5′-uORF’s, the MCT-1:DENR complex has been shown to increase cell proliferation and the translation of survival-related transcripts through the combination of two critical RNA-binding domains. The goal of this project has been to biophysically characterize the formation and activity of this complex and to develop a method for evaluating the effects of disrupting its formation in vivo through the combination of NMR, X-ray crystallography, cell-free and cell-based assays. Ultimately, the information gained from this study will be used to evaluate a library of perturbagens that interfere with dimer formation and the development of MCT-1 driven anti-apoptotic phenotypes. Citation Format: Sean D. Stowe, Michael C. Cavalier, Raquel Godoy-Ruiz, Kristen J. Varney, Paul T. Wilder, Ronald B. Gartenhaus, David J. Weber. Targeting the translational enhancer complex MCT-1:DenR to disrupt NHL survival. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2454. doi:10.1158/1538-7445.AM2015-2454
Psychiatrist-wife-mother: some aspects of role integration
Authors: M Scher, E Benedek, A Candy, K Carey, J Mules, B Sachs
Journal: American Journal of Psychiatry (1976)

Throughout her professional life the woman who chooses to combine the roles of psychiatrist, wife, and mother may find them not only compatible but complementary. If she can adopt a philosophy of life that permits her to function in these roles, and if those around her support her activities, she can perform with relative ease and proficiency. Her lifestyle must of necessity differ from that of her male colleagues, but differing lifestyles among members of a profession vitalize the field. A broad perspective is desirable, especially in a profession that deals with the emotional and mental lives of people. Married women and mothers afford such a broadened perspective to the field of psychiatry.
Abstract P4-01-06: Microcalcifications as imaging biomarker in breast cancer: High-throughput radiogenomic analysis using microarrya data
Authors: SU Shin, W Kim, SE Song, A Chu, W Han, WK Moon
Journal: Cancer Research (2016)

Abstract Purpose: To investigate relationships between microcalcifications and gene expression pattern using microarray analysis in breast cancer. Materials and methods: The institutional review board approved this retrospective study and waived the informed consent. Clinicopathologic finding, mammographic features, and gene expression data were evaluated in 133 women (mean age, 50.1 years; range, 21-79 years) with stage I-III breast cancer. Women with microcalcifications (n=33) and without microcalcifications (n=100) were compared. Immunohistochemical analysis of estrogen receptor, progesterone receptor, HER-2, and Ki-67 expression was performed. Differentially expressed genes (DEGs) using Affymetrix GeneChip® Human Gene 2.0 ST arrays (53,427 probes) were identified in tissue with microcalcifications versus without microcalcifications. In addition, genes included in the prediction analysis of PAM50, MammaPrint® and OncotypeDX® were also compared between two groups (microcalcifications versus no calcification). To further investigate the functions and underlying biology of DEGs, we performed enrichment analysis using the Gene Ontology database and pathway anlyais using the Kyoto Encyclopedia of Genes and Genomes database and Ingenuity Pathway Analysis. Results: Among clinicopathologic varibales, HER2 positivity (p&amp;lt;0.001) and presence of comedo necrosis (p=0.024) are significantly higher in the calcification group. About 128 genes had differential expression (&amp;gt; 1.5 fold difference, adjusted p value&amp;lt;0.05). Among known gene signatures, GRB7 (fold change=2.26, p=0.006) and ERBB2 (fold change=2.13, p=0.001) which are known as associated with recurrence, cell invasion and poor survival were highly expressed. In contrast, ZNF385B which is associated with p53-mediated apoptosis and good prognosis was underexpressed (fold change=0.39, p=0.001) in calcification group. Significant gene ontology terms included response to wounding, coagulation, wound healing, and response to hypoxia. Network and canonical pathway analysis indicated that increased cellular movement, cellular growth and proliferation, cellular develoment, coagulation and atherosclerosis signaling in breast cancer with microcalcifications, suggesting biological aggressiveness. Conclusion: Gene expression patterns are different according to microcalcifications status in breast cancer. Breast cancers with mammographic microcalcifications are associated with metabolic aggressiveness and poor prognosis. Citation Format: Shin SU, Kim W, Song SE, Chu A, Han W, Moon WK. Microcalcifications as imaging biomarker in breast cancer: High-throughput radiogenomic analysis using microarrya data. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-01-06.
Collagenases
Authors: Edward D. Harris, Stephen M. Krane
Journal: New England Journal of Medicine (1974)

"... native collagen is unaffected by enzymes of mammalian origin acting within the pH range that exists in connective tissue..."1THIS comment, written in 1959 in a review of the structure and stability of collagen, was an accurate assessment of the biomedical literature at that time. However, multiple biologic and pathologic situations — ranging from remodeling of long bones during growth,2 resorption of the uterus after parturition3,4 to the rapid development of trophic ulcers of the skin in paralyzed patients5 and destruction of joints in rheumatoid arthritis6 — suggested that there were indeed enzymatic mechanisms for destruction of collagen.Then, . . .
Abstract B49: Giant cancer stem cells of high-grade ovarian serous carcinoma .
Authors: Jinsong Liu
Journal: Clinical Cancer Research (2016)

Abstract Polyploid giant cancer cells (PGCCs) have been observed by pathologists for over a century. PGCCs or nuclear atypia are an important diagnosis feature for high grade serous carcinoma and frequently present in post-chemotherapy patients and contribute to tumor heterogeneity, but their functions are largely undefined. Little attention has been given to these cells, largely because PGCCs have been generally thought to originate from repeated mitosis/cytokinesis failure and have no capacity for long-term survival and cell proliferation. Here we report that we successfully purified and cultured PGCCs from human ovarian cancer cell lines and primary ovarian cancer. These cells are highly resistant to oxygen deprivation and could form through endoreduplication or cell fusion, generating regular-sized cancer cells through budding or burst. They are positive for normal and cancer stem cell markers, divided asymmetrically and cycled slowly. They can differentiate into adipose, cartilage, bone, and erythroid cells. A single PGCC formed cancer spheroids in vitro and generated tumors in immunodeficient mice. PGCC-derived tumor gained a mesenchymal phenotype with increased expression of cancer stem cell markers CD44 and CD133 and become more resistant to the treatment of cisplatin. Together, our results reveal that the PGCCs present a resistant form of human cancer cells like mother cancer stem cells that can contribute to generation of daughter cancer stem-like cells. The PGCCs may play a fundamental role in regulating tumor heterogeneity, stemness, and chemoresistance in human cancer. In contrast to the phenotype unstable cancer stem cells selected by cell surface markers, PGCCs can be stably passaged and maintained, thus these cells provide reproducible experimental system to study mechanisms involved in generation of ovarian cancer stem cells. Citation Format: Jinsong Liu. Giant cancer stem cells of high-grade ovarian serous carcinoma . [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B49.
Never Look a Gift Horse in the Mouth? Four Reasons Not to Blur the Line Between Research and Care in Low- and Middle-Income Countries
Authors: Wim Pinxten, Raffaella Ravinetto, Anne Buvé
Journal: The American Journal of Bioethics (2016)

In their target article “Clinical Trials Infrastructure as a Quality Improvement Intervention in Low- and Middle-Income Countries,” Denburg and colleagues (2016) suggest that it makes sense for low...
Clinical Evaluation of Combined Endoscopic Variceal Ligation and Sclerotherapy of Gastric Varices in Liver Cirrhosis
Authors: Y Arakaki, K Murakami, K Takahashi, R Sato, T Okimoto, H Ishitobi, M Nasu, J Kagawa, M Kodama, T Fujioka
Journal: Endoscopy (2003)

Endoscopic injection sclerotherapy (EIS) using cyanoacrylate and balloon-occluded retrograde transvenous obliteration (B-RTO) are the main procedures used to treat gastric varices. However, neither technique is free of problems. EIS for gastric varices may cause embolism in other organs; B-RTO requires a gastrorenal shunt and may aggravate esophageal varices. We have developed a combined form of endoscopic therapy involving band ligation and sclerotherapy which is an effective and safe procedure for treating gastric varices.Fifty-six patients with gastric varices and liver cirrhosis were treated at Almeida Memorial Hospital from June 1997 to May 2002 using the combined procedure. Each gastric varix was tightly ligated with O-rings, and 1 % polidocanol was injected into the submucosa around the ligated varix. If necessary, additional sclerotherapy was carried out after the initial treatment.The rate of hemostasis for variceal bleeding was 100 %, and no critical complications were noted. Complete disappearance of the gastric varices was observed endoscopically in all cases. Computed tomography showed that collateral vessels outside the gastric wall were not occluded by the treatment. Endoscopic follow-up examinations were carried out, and gastric varices recurred in seven patients (12.5 %). Only two of the patients (3.6 %) had a small amount of oozing bleeding. Additional endoscopic variceal ligation (EVL) and/or EIS were performed in these seven cases, and none of the patients died as a result of a bleeding gastric varix.The combined procedure was easily performed immediately after endoscopic examination, and required no special apparatus. It was found to be a safe and effective method of treating gastric varices.
Tulip-bundle technique as rescue hemostatic therapy in a deep Mallory–Weiss tear
Authors: Ana Ponte, Rolando Pinho, Joana Silva, Jaime Rodrigues, João Carvalho
Journal: Endoscopy (2016)

An 80-year-old woman who was anticoagulated with rivaroxaban for a previous deep venous thrombosis of the left lower limb presented with a 12-hour history of hematemesis. Her physical examination was unremarkable, and she had a blood pressure of 153/78 mmHg and heart rate of 75 beats/minute. Laboratory test results showed a hemoglobin level of 13.1 g/dL. Upper gastrointestinal endoscopy revealed a deep Mallory–Weiss tear with a visible vessel and active pulsatile bleeding located in a hiatus hernia ([Fig. 1 a]).
Geographic Variation in the Association between Ambient Fine Particulate Matter (PM <sub>2.5</sub> ) and Term Low Birth Weight in the United States
Authors: Yongping Hao, Heather Strosnider, Lina Balluz, Judith R. Qualters
Journal: Environmental Health Perspectives (2015)

Studies on the association between prenatal exposure to fine particulate matter ≤ 2.5 μm in aerodynamic diameter (PM2.5) and term low birth weight (LBW) have resulted in inconsistent findings. Most studies were conducted in snapshots of small geographic areas and no national study exists.We investigated geographic variation in the associations between ambient PM2.5 during pregnancy and term LBW in the contiguous United States.A total of 3,389,450 term singleton births in 2002 (37-44 weeks gestational age and birth weight of 1,000-5,500 g) were linked to daily PM2.5 via imputed birth days. We generated average daily PM2.5 during the entire pregnancy and each trimester. Multi-level logistic regression models with county-level random effects were used to evaluate the associations between term LBW and PM2.5 during pregnancy.Without adjusting for covariates, the odds of term LBW increased 2% [odds ratio (OR) = 1.02; 95% CI: 1.00, 1.03] for every 5-μg/m(3) increase in PM2.5 exposure during the second trimester only, which remained unchanged after adjusting for county-level poverty (OR = 1.02; 95% CI: 1.01, 1.04). The odds did change to null after adjusting for individual-level predictors (OR = 1.00; 95% CI: 0.99, 1.02). Multi-level analyses, stratified by census division, revealed significant positive associations of term LBW and PM2.5 exposure (during the entire pregnancy or a specific trimester) in three census divisions of the United States: Middle Atlantic, East North Central, and West North Central, and significant negative association in the Mountain division.Our study provided additional evidence on the associations between PM2.5 exposure during pregnancy and term LBW from a national perspective. The magnitude and direction of the estimated associations between PM2.5 exposure and term LBW varied by geographic locations in the United States.
Abstract B36: NF-kappaB-dependent and -independent roles for NIK in regulating GBM cell invasion
Authors: Camille L. Duran, Linda Herrera de Lechuga, Dong W. Lee, Kayla J. Bayless, Raquel Sitcheran
Journal: Cancer Research (2015)

Abstract The aggressive invasion of GBM cells into healthy brain tissue is a major factor contributing to the therapy resistance and poor prognosis of this malignancy. Our recent results demonstrated that the alternative, or noncanonical, NF-kappaB signaling pathway, predominates in the aggressive mesenchymal subtype of GBM. Additionally, NF-kappaB-inducing kinase (NIK), a key upstream activator of noncanonical NF-kappaB signaling, robustly promotes GBM cell invasion and pathogenesis. We demonstrate that expression of NIK is increased in response to exposure to collagen, a major extracellular matrix (ECM) protein present in GBM tumors, with NIK protein levels continuing to increase during invasion in 3D collagen matrices. Interestingly, NIK expression levels correlates with induction of membrane type-1 matrix metalloproteinase (MT1-MMP), a critical enzyme in many invasive tumors, functioning to degrade the basement membrane and ECM during cell migration and invasion. We provide evidence that NIK promotes MT1-MMP activation through increased phosphorylation at membrane protrusions and elevated enzymatic activity. Notably, the activation of MT1-MMP and the pro-invasive effects of NIK persist in the absence of the downstream NF-kappaB transcription factors RelA/p65 and RelB. Together, these data demonstrate a novel ability of NIK to promote GBM cell migration and invasion that is independent of NF-kappaB transcriptional activation functions. The results underscore the therapeutic potential of targeting noncanonical NF-kappaB signaling in these highly invasive tumors. Citation Format: Camille L. Duran, Linda Herrera de Lechuga, Dong W. Lee, Kayla J. Bayless, Raquel Sitcheran. NF-kappaB-dependent and -independent roles for NIK in regulating GBM cell invasion. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr B36.
Freedon of inquiry and subjects' rights: an introduction
Authors: D Reiss
Journal: American Journal of Psychiatry (1977)

The author introduces the Special Section papers to follow, pointing out that two new issues have attached themselves to the issue of the physical safety and civil dignity of human subjects. One new issue is an emphatically legal defense of the concept of subjects' rights; the other is the evolution of political characterizations and caricatures of many forms of research.
Abstract P4-09-09: Verification of the breast cancer progression-associated miRNA hsa-miR-199a-5p using NanoString® platform
Authors: T Fehm, S Schultz, H Bartsch, K Petat-Dutter, S Kahlert, K Sotlar, D Niederacher, H Neubauer
Journal: Cancer Research (2016)

Abstract A fundamental and clinically important step during breast tumourigenesis is the transition from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC). Improved knowledge of this transition from pre-invasive to invasive breast cancer will pave the way for novel preventative and therapeutic strategies. We have previously reported on differential expression of the miRNA hsa-miR-199a-5p in 15 matched pairs of DCIS and IDC areas isolated by laser capture microdissection (LCM) from formalin fixed and paraffin embedded (FFPE) breast cancer tissues using Illumina miRNA BeadChip microarray platform. Differential expression of hsa-miR-199a-5p was validated by quantitative RT-PCR in additional independent DCIS/IDC sample pairs from 25 breast cancer patients. Knock down of hsa-miR-199a-5p in invasive MDA-MB-231 and TMX2-28 breast cancer cells using a specific inhibitor significantly reduced invasiveness by approx. 73% and 71%, respectively (P &amp;lt;0.01 and P&amp;lt;0.05). Now we report on experiments to validate differential expression of hsa-miR-199a-5p using a new platform – NanoString® (nCounter® miRNA Expression Assay, NanoString Technologies®). The NanoString® System is an automated, digital detection and counting system which uses a novel barcoding technology to directly profile up to 800 miRNAs simultaneously from a single sample. Total RNA from 6 DCIS/IDC FFPE tumours was used for miRNA expression analysis. This analysis resulted in 10 differentially expressed miRNAs including hsa-miR-199a-5p which is upregulated in IDC (P &amp;lt;0.05). Besides hsa-mir-199a-5p, hsa-miR-222 is significantly differentially expressed between DCIS and IDC which could be found in both expression data sets (Illumina® and NanoString®). In this project we identified candidate progression-associated miRNAs which are differentially expressed between DCIS and IDC. Hsa-miR-199a-5p was validated in an independent sample cohort and its expression was further verified using the new miRNA expression analysis platform NanoString®. Hsa-miR-199a5-p is influencing in vitro cell invasiveness and may therefore be a potential drugable regulator of tumour progression and invasion in breast cancer. Citation Format: Fehm T, Schultz S, Bartsch H, Petat-Dutter K, Kahlert S, Sotlar K, Niederacher D, Neubauer H. Verification of the breast cancer progression-associated miRNA hsa-miR-199a-5p using NanoString® platform. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-09-09.
A controlled study of transitional day care for non-chronically-ill patients
Authors: I D Glick, L Fleming, N DeChillo, N Meyerkopf, C Jackson, D Muscara, M Good-Ellis
Journal: American Journal of Psychiatry (1986)

The authors randomly assigned 79 inpatients with nonchronic schizophrenia or affective disorder to either an intensive experimental day program called "transitional treatment" or a control treatment--weekly clinically believed to require intensive posthospital treatment to make the transition to the community. Although initially there was a significantly higher dropout rate from the control condition, at the point of discharge from the two programs as well as at 6- and 12-month follow-up there was no difference in outcome. Direct costs for the transitional treatment, however, were much higher.
A clinical study of four Unification church members
Authors: A Deutsch, M J Miller
Journal: American Journal of Psychiatry (1983)

Four women who were or had been members of the Unification church were studied by means of clinical interviews and psychological tests. The authors found that these women shared the following characteristics: 1) difficulties with heterosexual relations; 2) idealism and usually the wish to serve or unify others; 3) a spiritual world view with "magical-mystical" overtones; and 4) a tendency to deny and "wish away" threatening perceptions, specifically noted in projective testing. They suggest how these characteristics may have influenced the subjects' affinity for the life style and doctrines of the sect.
Dorpsstraat
Authors: M Therese Southgate
Journal: JAMA (2006)

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In Utero Depletion Of Fetal Host Hematopoietic Stem Cells Improves Engraftment Following Neonatal Transplantation In Mice
Authors: Chris Derderian, Charmin King, Priya Togarrati, Agnieszka Czechowicz, Ninnia Lescano, Damien Reynaud, Emmanuelle Passegue, Irving L Weissman, Tippi MacKenzie
Journal: Blood (2013)