tbuckley/cabot-search huggingface dataset:
THU0605-HPR Patterns of Physical Activity Matter: Bout Analysis Reveals Differences Between Patients with Axial Spondyloarthritis and Healthy Controls
Authors: T. Swinnen, M. Milosevic, T. Scheers, J. Lefevre, S. Van Huffel, W. Dankaerts, R. Westhovens, K. de Vlam
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Low total physical activity (PA) levels and remarkably less (very)vigorous physical activities have been shown in patients with axial spondyloarthritis (aSpA) compared to healthy controls using objective sensor-based technology<sup>1</sup>. Ten minute bouts of moderate to (very)vigorous PA (instead of frequent interruptions) are associated with additional health benefits. These within-day patterns of PA are unknown in aSpA. <h3>Objectives</h3> To compare PA patterns (bouts) between patients with aSpA and healthy controls. <h3>Methods</h3> PA was compared between 40 patients with aSpA (male/female: 24/16; Mean ± SD, Age:44.38±11.30 yrs, BMI:26.27±5.11 kg/m<sup>2</sup>, disease duration: 11.40±9.50 yrs) and 40 healthy, age and sex matched controls (Age:44.33±10.63 yrs, BMI:25.05±3.59 kg/m<sup>2</sup>) during five consecutive days (three weekdays and two weekend days) using the SenseWear Pro3 Armband. Weekly PA accumulated in 10-minute bouts (A) and the number of bouts (N) for each PA intensity level were contrasted between groups with Wilcoxon signed- rank tests (p&lt;.05). Differences with prior non-bout (NB) data were provided for comparison with median group differences in %. <h3>Results</h3> Weekly vigorous and very vigorous PA were significantly lower in aSpA irrespective of analysis technique (vigorous: NB: p&lt;0.001,A&amp;N: p=.003; very vigorous: NB p&lt;001,A&amp;N p=.008). Bouts analysis revealed novel and more profound (%) differences for moderate PA (NB: p=.070,-28%, A: p=.062,-49%, N:.046,-55%) and moderate to (very)vigorous PA (NB: p=.029,-32%, A: p=.003,-65%, N:p=.002,-67%) with lower values for patients. Thus in absolute terms, patients accumulate 21 minutes (trend) and two 10-minute bouts (significant) less moderate PA per day, a difference not detected with NB analysis. Similarly, patients performed 40 minutes and three 10-minute bouts less moderate to (very)vigorous PA. No differences between groups were found for inactivity and light PA (p&gt;.05). <h3>Conclusions</h3> Bout analysis revealed additional differences in health-enhancing PA behavior between patients with aSpA and healthy controls. This work adds to the emerging body of evidence showing lower PA in this patient group. Future work in aSpA should focus on the consequences of low PA, its relevance for outcome assessment and on the development of tailored PA interventions. <h3>References</h3> Swinnen TW, Scheers T, Lefevre J, Dankaerts W, Westhovens R, de Vlam K. Physical activity assessment in patients with axial spondyloarthritis compared to healthy controls: a technology-based approach. PLoS One. 2014 Feb 28;9(2): e85309. <h3>Disclosure of Interest</h3> None declared
Vital Signs: Predicted Heart Age and Racial Disparities in Heart Age Among U.S. Adults at the State Level
Authors: Quanhe Yang, Yuna Zhong, Matthew Ritchey, Mark Cobain, Cathleen Gillespie, Robert Merritt, Yuling Hong, Mary G. George, Barbara A Bowman
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Cardiovascular disease is a leading cause of morbidity and mortality in the United States. Heart age (the predicted age of a person's vascular system based on their cardiovascular risk factor profile) and its comparison with chronological age represent a new way to express risk for developing cardiovascular disease. This study estimates heart age and differences between heart age and chronological age (excess heart age) and examines racial, sociodemographic, and regional disparities in heart age among U.S. adults aged 30-74 years.Weighted 2011 and 2013 Behavioral Risk Factor Surveillance System data were applied to the sex-specific non-laboratory-based Framingham risk score models, stratifying the results by age and race/ethnic group, educational and income level, and state. These results were then translated into age-standardized heart age values, mean excess heart age was calculated, and the findings were compared across groups.Overall, average predicted heart age for adult men and women was 7.8 and 5.4 years older than their chronological age, respectively. Statistically significant (p<0.05) racial/ethnic, sociodemographic, and regional differences in heart age were observed: heart age among non-Hispanic black men (58.7 years) and women (58.9 years) was greater than other racial/ethnic groups, including non-Hispanic white men (55.3 years) and women (52.5 years). Excess heart age was lowest for men and women in Utah (5.8 and 2.8 years, respectively) and highest in Mississippi (10.1 and 9.1 years, respectively).The predicted heart age among U.S. adults aged 30-74 years was significantly higher than their chronological age. Use of predicted heart age might 1) simplify risk communication and motivate more persons to live heart-healthy lifestyles and better comply with recommended therapeutic interventions, and 2) motivate communities to implement programs and policies that support cardiovascular health.
Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011
Authors: P Gaibani, A C Finarelli, R Cagarelli, A Pierro, G Rossini, M Calzolari, M Dottori, P Bonilauri, M P Landini, V Sambri
Journal: Eurosurveillance (2012)

Preview this article: Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo-encephalitis does not reveal past Japanese encephalitis virus infection, Emilia Romagna, Italy, 2011, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/35/art20257-en-1.gif
Enzymatic Desamidation of Glutamine in the Presence of Pyruvate Furnished by Concomitant Reactions
Authors: Gonçalves, Jose M., Greenstein, Jesse P.
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Enzymatic Desamidation of Glutamine in the Presence of Pyruvate Furnished by Concomitant Reactions Get access Jose M. Gonçalves, Jose M. Gonçalves follow of the Rockefeller Foundation National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 269–274, https://doi.org/10.1093/jnci/7.4.269 Published: 01 February 1947 Article history Received: 17 December 1946 Published: 01 February 1947
FRI0413 Comorbidity in a Cohort of Primary Sjögren's Syndrome Patients
Authors: M. Fernandez Castro, J.L. Andreu, J. Rosas, V. Martínez Taboada, A. Olivé, C. Sánchez-Piedra, R. Menor, B. Rodriguez, A. García Aparicio, F.J. Lόpez Longo, S. Manrique-Arija, J.A. García Vadillo, S. Gil Barato, R. Lόpez González, F.J. Narváez, C. Galisteo, J. González Martín, E. Ruiz Lucea, C. Erausquin, C. Guillén Astete, I. Castellvi, C. Bohόrquez, J. Loricera, J. Belzunegui
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Primary Sjögren9s syndrome (pSS) is a chronic systemic autoimmune disease with a substantial impact on patient9s quality of life and associated comorbidities could worsen the prognosis and complicate the management of the disease. <h3>Objectives</h3> The aim of our study was to describe comorbidities in a Spanish cohort os pSS patients. <h3>Methods</h3> We took advantage of a multicenter descriptive transversal study of a cohort of pSS patients fulfilling European/American criteria. It is a randomised register of patients obtained from thirty three Reumathology clinics all over Spain. The presence of comorbidities was investigated in every patient. Previous informed consent was obtained and local ethics committees approved the study. Variables were analysed by descriptive statistical methods, using means, medians, and rates, with their deviations and interquartile ranges (p25-p75). <h3>Results</h3> A total of 437 patients were included, 95% of them women, with a median age of 58 years. Dyslipidemia was the most common comorbidity, appearing in 33% of the cases, with hypertension in second place with a prevalence of 25%. Osteoporosis was present in 18% of patients. Furthermore, 37 patients had at least an osteoporotic fracture. Seventy four patients had never smoked. Diabetes was present in 6% of cases. Less than 7% of the patients had some kind of cardiovascular event: 4 patients ischemic heart disease, 14 patients peripheral arterial disease and 15 patients strokes. Among patients with peripheral arterial disease, only one patient showed positive anti phospholipid antibodies. Thirteen patients (3%) had heart failure. Sixty four patients (14%) had fibromyalgia. Five patients (1%) had celiac disease and 2 (0.46%), multiple sclerosis. Seven lymphomas were observed, four of them MALT type and two Hogdkin9s disease. Three patients developed multiple myeloma and two Waldenstrom9s macroglobulinemia. Twenty one cases of other malignancy were registered. <h3>Conclusions</h3> Primary Sjögren9s syndrome9s patients frequently present associated comorbidities, been dyslipidemia, arterial hypertension and osteoporosis the most prevalent. Lymphoma prevalence rate for this series is 1,6 percent. <h3>Disclosure of Interest</h3> None declared
Prevalence of HIV-2 infection in Europe
Authors: F Cazein, F F Hamers, J Alix, J B Brunet
Journal: Eurosurveillance (1996)

The HIV/AIDS pandemic is primarily caused by HIV-1. Another type of virus, HIV-2, is found mainly in certain West African countries In Europe, most of the cases of HIV-2 infection described have been in people from Africa. The objective of this study was
Prevalence of nosocomial infections in two Latvian hospitals.
Authors: U Dumpis, A Balode, D Vīgante, I Narbute, R Valinteliene, V Pïrags, A Martinsons, I Vingre
Journal: Eurosurveillance (2003)

The first point prevalence survey of the nosocomial infection (NI) rate was conducted in two Latvian hospitals. At the time of the survey 17.5% (226/1291) patients had symptoms or were being treated for infection. The overall prevalence rate was 5.6% (72/1291) for NI and 12.7% for community acquired infections (164/1291). Surgical site infection (SSI) was the most common NI (62%) followed by respiratory tract infection (RTI) (7.5%), and urinary tract infection (UTI) (6.4%). NI rate was higher with increasing age of patients, in intensive care units and surgical wards, and among those who had an intravenous device or urinary catheter. Microbiological investigation yielded positive results in 29% (21/72) of patients with NIs. Antibacterial treatment was given to 22.3% (288/1291) of hospitalised patients and in 62% (182/288) of these, cefazolin was prescribed. Results from this study will be used to plan a national prevalence survey.
PWE-404 Emergency general surgery: emergence of a subspecialty by stealth
Authors: L Pearce, E Parkin, S Smith, J Kennedy, A Macdonald
Journal: Gut (2015)

<h3>Introduction</h3> Emergency surgical patients account for around half of all NHS surgical workload and 80% of surgical deaths. Few trainees opt to CCT in General Surgery, and there is no recognised subspecialty training program in Emergency General Surgery (EGS). Despite this lack of training and relevant assessment by examination, there appears to be an increasing number of EGS posts advertised. This may be associated with a reduction in the numbers of breast or vascular surgery posts that have general surgical commitments. We sought to explore changes in consultant surgeon job adverts over time. <h3>Method</h3> All consultant surgeon posts, advertised in the British Medical Journal between January 2009 and December 2014 were included. Posts in 9non-general surgical9 specialties were excluded. Data collected included specialty, region and institute of advertised post. For the purposes of statistical analysis, data was divided into two separate year bands: 2009 – 2011 and 2012 – 2014. Statistical analysis was by Chi-squared test; p &lt; 0.01 was considered statistically significant. <h3>Results</h3> Over the six-year study period, there were 1240 consultant job adverts in a general surgical specialty. Nine hundred and seventy-five were substantive posts; the region with the most jobs was London and the South East (n = 278). The total number of posts was 645 in 2009–11 and 595 2012–14. The most common specialties advertised were colorectal (313), breast (248), upper GI (207), pure general surgery (170) and vascular (80). There were 55 jobs advertised in EGS, either with (20) or without (35) another subspecialty. The number of EGS adverts increased significantly in 2012–14 compared to 2009–11 (p = 0.008). London and the South East were the highest recruiters to EGS posts (10% of all consultant surgeon posts advertised in the region). There was a borderline decrease in the number of breast with general surgery posts advertised (p = 0.021). Numbers of vascular with general surgery jobs and purely general surgery jobs did not change significantly over time. <h3>Conclusion</h3> This data demonstrates increasing societal need for EGS consultants over the last six years and the emergence of Emergency Surgery as a new subspecialty. The current training system in EGS on an ‘ad hoc’ basis alongside subspecialty training, may not adequately prepare newly appointed consultants. This is confounded by shortened training times in pre-existing subspecialties and introduction of EWTD. In order to meet the EGS needs of the NHS, general surgical training and the examination system need to be revised. <h3>Disclosure of interest</h3> None Declared.
Medical History Begets Humility
Authors: E J HUTH
Journal: Annals of Internal Medicine (1962)

Editorials1 February 1962Medical History Begets HumilityE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-56-2-353 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOf pleasures we get from reading history, the one rarely confessed is the looking back in time to see an eminent and usually wise man slip on a conceptual banana peel. Was Benjamin Rush's zealous blood-letting such a slip by such a man? In Philadelphia's yellow fever epidemic of 1793 he probably killed more Philadelphians with his fervent, evangelical "erythromania"* than he saved. His reputation was so vulnerable on this point that one of his political enemies, the Royalist William Cobbett, though a layman, could attack Rush more viciously on medical than on political grounds:The times are ominous indeed,...Reference1. HAYWARD OS: The basis in Sydenham, Rush, and Armstrong for Nathan Smith's practice. Ann. Intern. Med. 56: 343, 1962. LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *A term used by Hayward (1) in his paper "The Basis in Sydenham, Rush, and Armstrong for Nathan Smith's practice." By this term Hayward refers to Rush's enthusiasm for blood-letting, and not to excessive blushing, the usual definition. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 February 1962Volume 56, Issue 2Page: 353-354KeywordsFevers Issue Published: 1 February 1962 PDF downloadLoading ...
Role of thoracic radiotherapy in limited-stage small-cell lung cancer: quantitative review based on the literature versus meta-analysis based on individual data.
Authors: J P Pignon, R Arriagada
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.11.1819 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1328553 Role of thoracic radiotherapy in limited-stage small-cell lung cancer: quantitative review based on the literature versus meta-analysis based on individual data. J P PignonxJ P PignonSearch for articles by this author , R ArriagadaxR ArriagadaSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.11.1819 PDF "Role of thoracic radiotherapy in limited-stage small-cell lung cancer: quantitative review based on the literature versus meta-analysis based on individual data.." Journal of Clinical Oncology, 10(11), pp. 1819–1820© 1992 by American Society of Clinical Oncology
Abstract 46: Temporal Ubiquitin-Proteasomal Degradation of Smad9 Mediated by its Specific E3 Ligase Asb2 is Required for Cardiac Development through the Regulation of Tbx2 Expression
Authors: Kyung-Duk Min, Masanori Asakura, Shin Ito, Miki Imazu, Kazuhiro Shindo, Masafumi Kitakaze
Journal: Circulation Research (2014)

Background: The bone morphogenetic protein (BMP) pathway plays crucial roles in cardiac development. Recent studies have reported that mutations in Smad9, one of the regulatory Smad specific for the BMP pathway, might result in cardiovascular diseases. However, both regulation and function of Smad9 in the cardiovascular system have not been elucidated. Methods and Results: We conducted DNA microarray using P19CL6 cells with forced expression of Smad9. Microarray analysis using Ingenuity Pathway Analysis elucidated that 19 genes including Tbx2 were related to BMP pathway and showed significantly altered expression levels by transient expression of Smad9. We confirmed by qRT-PCR that only Tbx2, but not other Tbx families, were induced by Smad9. Importantly, the expression of Tbx2 was more up-regulated by Smad9 than by Smad1. Moreover, we identified Asb2 as a specific E3 ligase that targets Smad9, but not Smad1/5, for proteasomal degradation. The in situ hybridization using murine embryo revealed that Asb2 is expressed predominantly in the heart during embryonic development, suggesting that Asb2 quantitatively regulates Smad9 in the developing heart. Biochemical analysis demonstrated that Tbx2 expression induced by Smad9 was attenuated by Asb2, which was restored by the treatment with proteasome inhibitor, lactacystin. Developmental studies using both P19CL6 cells and zebrafish showed that the ablation of Asb2 leads accumulation of Smad9 resulting in the up-regulation of Tbx2, which attenuates myocardial development while induces non-myocardial tissue including cardiac cushion. Indeed, alcian blue staining of morpholino-mediated knockdown of zebrafish Asb2 showed significantly dilated ventricle and thinned ventricular wall, accompanied with decreased myocardium and increased cardiac jelly. Conclusions: Smad9 induces the expression of Tbx2 during cardiac development and is temporally and quantitatively regulated by its specific E3 ligase Asb2. This is the first study to show both the target gene and specific E3 ligase of Smad9.
Human Listeria monocytogenes infections in Europe - an opportunity for improved European surveillance
Authors: J Denny, J McLauchlin
Journal: Eurosurveillance (2008)

The 2006 Community Summary Report from the European Food Safety Authority (EFSA) and the European Centre for Disease Prevention and Control (ECDC) was published recently with the latest trends and figures on the occurrence of zoonotic infections and agents, antimicrobial resistance and foodborne outbreaks in the then 25 European Union (EU) Member States and five non-EU countries. This article seeks to expand further upon reports of human listeriosis (Listeria monocytogenes infections) and changes in the epidemiology of this disease, in order to inform of important developments as they relate to an opportunity for the establishment of a formalized listeriosis surveillance network in Europe.
A comparison of high- and low-dose lorazepam with amylobarbitone in patients with anxiety states
Authors: K Schapira, H A McClelland, D J Newell
Journal: American Journal of Psychiatry (1977)

A double-blind crossover trial comparing lorazepam at two dosage levels with amylobarbitone supported previous reports of the effective anxiolytic action of the drug. Evaluation of the patients' responses during each week of treatment was based on a physician's weekly rating and on daily self-rating by patients. The results were analyzed by sequential and nonsequential analyses. The main side effect of the drug was drowsiness, which occurred to a clinically significant degree among the high-dose group of patients. The authors emphasize the value of two dosage trials, particularly in devising subsequent flexible individual treatment regimens.
Acute salicylate poisoning.
Authors: Dagmara Reingardiene, Robertas Lazauskas
Journal: BMJ (1972)

Although aspirin (acetylsalicylic acid) has become widely available without prescription, cases of self-poisoning due to overdose of salicylates are quite uncommon, with a low reported mortality. However, severe poisoning with these preparations is life threatening. Besides the aspirin, there are other sources of salicylate poisoning, such as an excessive application of topical agents, ingestion of salicylate containing ointments, use of keratolytic agents or agents containing methyl salicylate (e.g. oil of wintergreen). Most of these preparations are liquid, highly concentrated and lipid soluble, and, therefore, they are able to provoke a severe, rapid salicylate poisoning. On the basis of clinical and metabolic features or salicylate concentration in plasma it is very important to diagnose severe poisoning with salicylates in time and prescribe an adequate treatment. In the present review article various aspects of salicylate poisoning and its treatment are discussed: epidemiology, pharmacokinetics and pharmacodynamics of salicylates, clinical manifestations of their toxicity, management, enhanced elimination and prognosis.