tbuckley/cabot-search huggingface dataset:
B-Cell Receptor Profiling Suggests a Limited Number of Antigens Involved in the Pathogenesis of Chronic Lymphocytic Leukemia.
Authors: Mascha Binder, Fabian Müller, Mareike Frick, Claudia Wehr, Milena Pantic, Dietmar Pfeifer, Renata Pasqualini, Wadih Arap, Hendrik Veelken, Roland H. Mertelsmann, Martin Trepel
Journal: Blood (2008)
Primary Treatment of Waldenstrom's Macroglobulinemia with Dexamethasone, Rituximab and Cyclophosphamide (DRC): Final Analysis of a Phase II Study
Authors: Meletios A. Dimopoulos, Maria Roussou, Efstathios Kastritis, Evdoxia Hadjiharissi, Marie-Christine Kyrtsonis, Argiris Symeonidis, Panagiotis Repoussis, Eurydiki Michalis, Sosana Delimpasi, Konstantinos Tsatalas, Panagiotis Tsirigotis, Amalia Vassou, Elina Vervessou, Eirini Katodritou, Maria Gavriatopoulou, Dimitra Gika, Evangelos Terpos, Konstantinos Zervas
Journal: Blood (2012)
Factors That Increase Risk of Celiac Disease Autoimmunity After a Gastrointestinal Infection in Early Life
Authors: Kaisa M. Kemppainen, Kristian F. Lynch, Edwin Liu, Maria Lönnrot, Ville Simell, Thomas Briese, Sibylle Koletzko, William Hagopian, Marian Rewers, Jin-Xiong She, Olli Simell, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Jeffrey P. Krischer, Åke Lernmark, Heikki Hyöty, Eric W. Triplett, Daniel Agardh
Journal: Clinical Gastroenterology and Hepatology (2016)
R-CHOP21 Vs R-CHOP14 in 950 Diffuse Large B-Cell Lymphoma Patients: Results of a Multicentre Retrospective Study Form Italian Lymphoma Foundation (FIL)
Authors: Luigi Rigacci, Benedetta Puccini, Maria Giuseppina Cabras, Luca Nassi, Alberto Fabbri, Annalisa Chiappella, Alice Di Rocco, Monica Balzarotti, Michele Spina, Enrico Orciuolo, Angela Maria Mamusa, Silvia Franceschetti, Daniela Dessì, Lorenzo Iovino, Alice Pietrini, Sara Gandolfi, Paolo Paesano, Sofia Kovalchuk, Gemma Benelli, Gianluca Gaidano, Umberto Vitolo, Alberto Bosi
Journal: Blood (2012)
Association of Deferasirox and Vitamin D Promotes Cell Differentiation and Improves Overall Survival in Acute Myeloid Leukemia (AML) Elderly Patients After Demethylating Agents Failure: A Retrospective Case Control Study
Authors: Etienne Paubelle, Felipe Suarez, Florence Zylbersztejn, Celine Callens, Michael Dussiot, Marc Benhamou, Françoise Isnard, Marie T Rubio, Gandhi Damaj, Norbert C. Gorin, Jean-Pierre Marolleau, Ivan Cruz Moura, Olivier Hermine
Journal: Blood (2012)
AB0956 Atypical Patterns of Antinuclear Antibodies in Colombian General Population: Table 1.
Authors: J.A. Gόmez-Puerta, A. Londoño, V.E. Estrada, S.L. Puerta, S.M. Osorno, J.A. Carmona
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Since more common patterns of antinuclear antibodies (ANAs) such as homogeneous or nucleolar patterns are well recognized, the prevalence of uncommon or atypical pattern is not well described <h3>Objectives</h3> Our aim was to describe the prevalence of atypical ANAs patterns in a big cohort of ANA measurements in general Colombian population. <h3>Methods</h3> We included all ANAS determinations done during 2 consecutive years (2013 and 2014) from Dinamica IPS in 8 different cities in Colombia. We defined such as uncommon patters the following: anti MSA-2 (mitotic spindle apparatus), cytoplasmatic fibers, lysosomal, Golgi, multiple dots, NuMA1 (MSA-1), anti MSA-3, PCNA, centrosome and nuclear envelope. All patient sera submitted for ANAs testing were tested by conventional indirect immunofluorescence using Hep-2 cells (AESKU.DIAGNOSTICS, Wendelsheim, Germany). We use 3 images for sample and in some cases several dilutions were needed. Parametric test were used for comparison among groups. <h3>Results</h3> The overall sample included 113,491 consecutive samples for ANAs, being positive in 62,501 (55%) cases. 912 (1.45%) samples in 838 patients were classified as atypical pattern. Mean age for atypical positive pattern patients was 47±16.8 years and 80% of patients were female. The most common atypical patterns are summarized in Table. We did not find any difference among sex according atypical patterns. In subgroup analysis, centrosome pattern was more common in younger patients (&lt;18 years) than in older than 18 years (27.84% vs 11.5%; Chi2, p=0.001), anti MSA-2 pattern was significantly more common in patients &gt;18 years than in ≤18 years (23.6% vs 11.3%; Chi2, p=0.038), and cytoplasmic fibers was more prevalent in patients older than 55 years (14.7 vs 9%, p=0.013). <h3>Conclusions</h3> In this large cohort of almost 130.000 samples of ANAs from a Colombian general population, the prevalence of atypical ANAs was around 1.5%. That prevalence is in concordance with some other series (1). Anti NuMa and MSA-2 patterns were the most common atypical ANAS. Anti centrosome were more common in young people, anti MSA in middle age patients and anti cytoplasmic fibers in elderly population. <h3>References</h3> Vermeersch P et al. Autoimmunity Rev 2013;12:998–1003 <h3>Disclosure of Interest</h3> None declared
Successful Long- Term Outcome and Chimeric Status Following Allogeneic Stem Cell Transplantation for Non-Malignant Disorders Using Moderate T Cell Depletion with No Post Transplant Gvhd Prophylaxis.
Authors: Ronit Elhasid, Irina Zaidman, Khalil Abdalla, Miriam Ben-Arush, Nuhad Haddad, Tsila Zuckerman, Osnat Gidoni, Dina Rubin, Rina Katz, Shimon Polack, Yair Reisner, Jacob M. Rowe
Journal: Blood (2008)
Phase II Study of Liposome Encapsulated Doxorubicin Citrate Complex, NPLD (Myocet™) in Myelofibrosis with Myeloid Metaplasia (MMM).
Authors: Francesco Iuliano, Daniela Cilloni, Molica Stefano, Sterpone Paola, Di Maio Massimo, Gottardi Enrico, Messa Emanuela, Serra Anna, Peta Antonio
Journal: Blood (2006)
Effect of Treatment With Low Doses of Hydrocortisone and Fludrocortisone on Mortality in Patients With Septic Shock
Authors: Djillali Annane
Journal: JAMA (2002)

EVERE SEPSIS REMAINS AN IMPORtant cause of death, accounting for 9.3% of all deaths in the United States in 1995. 1 If our understanding of the mechanisms of host response to stress has strongly progressed during the last 2 decades, 2 the various drugs developed for specific targets of the cytokine cascade have failed to improve patient survival. 3,4orticosteroids were the first antiinflammatory drugs tested in randomized trials.At high doses during short courses, they did not induce favorable effects. 5,6However, the observation that severe sepsis may be associated with relative adrenal insufficiency 7,8 or systemic inflammation-induced glucocorticoid receptor resistance 9 prompted renewed interest of a replacement therapy
Abstract 10324: Balancing Work, Life and Health: A Mixed Methods Study Describing the Self-care Practices of an Older Working Population With Coronary Heart Disease (CHD)
Authors: Victoria Dickson, Jin Jun, Nicholas Warren, Gail D'Eramo Melkus
Journal: Circulation (2015)

For the 3.5 million workers with CHD, daily self-care (i.e., treatment adherence, symptom monitoring and symptom management) must take place within the context of work. Objective: To describe the self-care practices of aging workers (&gt;age 50 years) with CHD and examine the relationship of work organization (work processes and organizational practices), job-level factors and self-care. Methods: In this mixed methods study, 125 working adults with CHD completed valid and reliable instruments about organizational and job-related factors (job stress, job control, and work-life balance (WLB)), individual-level factors (mood, physical functioning) and self-care. A purposively selected subsample (n=40) participated in interviews about self-care within the context of work. Multiple regression examined the determinants of self-care. Then, qualitative data were analyzed using thematic content analysis, followed by data integration. Results: In this sample (69% Male, 85% White; mean age 59±5 years), 49% reported a recent myocardial infarction, 67% were overweight/obese and 60% had depressive symptoms. Overall, 68% reported adequate self-care (Self-Care Heart Disease Index mean 76±14) with significant differences in self-care by age, ethnicity and job type. There were significant interaction effects of job control and job type on self-care ( F 2.097, p =.038); and WLB and job type on self-care ( F 2.53, p =.024). Narrative accounts of self-care revealed that most struggled with diet and exercise due to job demands. These older workers with CHD reported competing WLB issues (e.g., as caregivers to adults vs. own health) for which they felt ill-equipped to manage. Those with poor self-care measured quantitatively reported feeling stressed and fatigued which they attributed to their job. Few interpreted the symptoms as related to CHD. Workers were selective in whom they discussed their CHD, self-care needs and daily symptoms, articulated as fear of discrimination and quantified as workplace injustice (mean 23±6). Conclusions: Self-care is challenging for many older workers with CHD and influenced by multi-dimensional factors. In this population with CHD, WLB encompasses balancing self-care with job and daily life responsibilities.
Protein ratio of OPRT/TS or OPRT/ (TS+DPD) evaluated by quantitative double fluorescence immunohistochemistry is a useful tool to predict drug efficacy of S-1 for gastric cancer
Authors: Keita Kai, Yoshihiko Kitajima, Kazuyoshi Hashiguchi, Osamu Tokunaga, Kohji Miyazaki
Journal: Cancer Research (2008)

1548   Background:  hymidylate synthase (TS), orotate phosphoribosyltransferase (OPRT) and dihydropyrimidine dehydrogenase (DPD) are known worldwide as key enzymes to predict efficacy of 5-FU treatment. We currently established a novel technology, quantitative double fluorescence immunohistochemistry (qDFIHC; Cancer Letters, 2007). In this method, cancer specimens were double stained by Cy3 labeled β-actin and FITC labeled target proteins. Total intensity of target protein/β-actin was automatically estimated on confocal Laser Scanning Microscope and the quantity of TS, DPD and OPRT expressions was determined.  Methods:  sing the qDFIHC method, we estimated expression levels of the 3 enzymes in 23 formalin-fixed paraffin-embedded gastric cancer tissues, which endoscopically obtained before S-1 based neoadjuvant chemotherapy. The expression values of the 3 proteins were compared with clinical response to the neoadjuvant chemotherapy.  Results:  atios of OPRT/DPD, OPRT/TS, and OPRT/ (DPD+TS) were revealed to be significantly higher in responder than non-responder to the neoadjuvant chemotherapy (P value: 0.0147, 0.0012, 0.0004, respectively).  Conclusions:  he Protein ratio of OPRT/TS or OPRT/ (TS+DPD) evaluated by qDFIHC might to be a powerful tool to predict drug efficacy by S-1 based neoadjuvant chemotherapy for gastric cancer. The qDFIHC enables us to assess protein expression level even in the formalin-fixed paraffin-embedded tiny biopsy specimens.
A Skin Cancer Prevention Campaign
Authors: Osvaldo Correia, Bernardo Correia, Ana Filipa Duarte
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Upregulation of the polycomb group protein EZH2 in proliferating, cultured mantle cell lymphoma.
Authors: H.P.J. Visser, M.J. Gunster, A.P. Otte, E.M.M. Manders, F.M. Raaphorst, R. Willemze, H.C. Kluin-Nelemans
Journal: Blood (2000)
The Efficacy and Safety of Darbepoetin Alfa for Treating Anemia in Low-Risk Myelodysplastic Syndrome Patients: Results after 53/55 Weeks.
Authors: Janice Gabrilove, Ronald Paquette, Roger M. Lyons, Chaudhry Mushtaq, Mikkael A. Sekeres, Hung Lam, Lyndah Dreiling
Journal: Blood (2006)
Doctor-Patient Communication and Perception of Treatment Discontinuation in Myelodysplastic Syndromes (MDS) Diverge at the Time of Disease Progression
Authors: Aaron T. Gerds, Betsy Dennison, Joan Latsko, Alice Houk, Stephanie Chisolm, John M. Huber, Richard M. Stone, Jaroslaw P. Maciejewski, Rami S Komrokji, Guillermo Garcia-Manero, David P. Steensma, Mikkael A. Sekeres
Journal: Blood (2014)
A case of heart failure and diarrhoea
Authors: Bradley Anderson, Sumera Rizvi, Grace Lin, Vandana Nehra
Journal: Gut (2016)

A 20-year-old man with no significant medical history presented with a 5-day history of intermittent chest pain and dyspnoea. He also reported a 3-month history of daily diarrhoea characterised by multiple, loose, watery, non-bloody stools. Physical examination was notable for tachycardia and a soft systolic murmur at the apex. Laboratory evaluation was significant for microcytic anaemia (serum iron 17 μg/dL; normal range 50–150 μg/dL) and an NT-proBNP (N-terminal pro-brain natriuretic peptide) of 18 995 pg/mL (normal <51 pg/mL). A colonoscopy with random biopsies for evaluation of diarrhoea was unremarkable. Esophagogastroduodenoscopy demonstrated a scalloped and mosaic pattern in the second and …
MPTH-36. COMPREHENSIVE GENOMIC ANALYSIS OF YOUNG ADULT GLIOBLASTOMAS REVEALS FOUR SUBCLASSES WITH DISTINCT DRIVER EVENTS
Authors: Shakti Ramkissoon, Manna Chang
Journal: Neuro-Oncology (2016)

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults; however, recent studies have shown that GBM is comprised of biologically and genetically distinct diseases which share a common morphologic appearance. In this study, we demonstrate that young adult GBMs (yaGBM, 18-40 years) comprise genomically distinct subclasses with unique collections of driver events. DNA was extracted from 271 yaGBM (female 110, male 161, median age 34 years) samples and comprehensive genomic profiling was performed using hybridization-capture, adaptor ligation-based libraries for 315 cancer-related genes including selected introns from 31 genes frequently rearranged in cancer. The most commonly altered genes were TP53 (65.3%), IDH1 (40.6%), ATRX (40.6%), CDKN2A/B (39.1%/33.6%), PTEN (24.0%), TERT (20.3%), NF1 (18.1%), PIK3CA (17.3%), CDK4 (15.5%), EGFR (14.0%), H3F3A (12.5%), PDGFRA (11.4%), and RB1 (11.4%). Genomic rearrangements included FGFR1-TACC1 (n=2), FGFR2-GKAP1 (n=1), FGFR3-TACC3 (n=2), and BRAF-KIAA1549 (n=1). Unsupervised latent class analysis revealed four distinct classes of yaGBM largely defined as (1) IDH1/TP53 mutant (2) IDH1/TP53 mutant with PDGFRA amplification, (3) H3F3A/TP53 mutant, and (4) PI3K activation (PTEN/EGFR mutant, TP53 wild type). The median tumor mutation burden (TMB) was 3.6 mutations/Mb (range <1 to 666 mutations/Mb). Samples with TMBs ≥ 10 mutations/Mb (n=39, 10.7%) were enriched for genomic alterations involving DNA repair/mismatch repair genes including MSH6 (23.9%), MLH1 (21.7%), ATM (19.6%), MLL2 (15.2%), and MSH2 (13.0%). Taken together these findings demonstrate that yaGBMs can be subdivided into four genetically distinct subclasses each with unique driver events. Furthermore, these findings highlight clinically actionable alterations for which targeted agents are available including IDH1, PIK3CA, PDGFRA, or EGFR inhibitors while a subpopulation of patients with hypermutated GBMs may benefit from immunotherapy agents.
Absence of Relationship of Myocardial T2* to Right Ventricular Function In Thalassaemia Major
Authors: Vassilios Perifanis, Antonia Kondou, Aikaterini Teli, Efthimia Vlachaki, Marina Economou, Giannoula Tsatra, George P Spanos, Miranda Athanassiou-Metaxa
Journal: Blood (2010)
Gene Expression Profile of Protein Kinases Reveals a Distinctive Signature of Chronic Lymphocytic Leukemia (CLL) and Points to a Role of Second Generation Protein Kinase Inhibitors.
Authors: Simona Tavolaro, Sabina Chiaretti, Monica Messina, Francesca R. Mauro, Ilaria Del Giudice, Roberta Maggio, Emanuela M. Ghia, Marilisa Marinelli, Simona Santangelo Miss, Anna Guarini, Robert Foa
Journal: Blood (2006)
AB0108 Resveratrol Inhibits Canonical Wnt Signaling and Ameliorates Experimental Arthritis
Authors: S.S. Koca, S. Yolbas, A. Yildirim, Z.B. Celik, E.E. Onalan, M. Akin
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is an inflammatory joint disorder, the progression of which leads to the destruction of cartilage and bone. Wnt signaling pathway act several important biological functions, such as cell differentiation, embryonic development, limb development and joint formation. Accumulated evidence has suggested that this signaling pathway plays a key role in the FLS activation, bone resorption and joint destruction in RA. <h3>Objectives</h3> The purpose of this study was to investigate the activity of Wnt/β-catenin pathway in collagen-induced arthritis (CIA) in rats, and to research the therapeutic effect of resveratrol in this arthritis model. <h3>Methods</h3> Thirty Wistar albino female rats were randomized to 3 groups (n=10 in each group): Group-I as the control group, Group-II as the arthritis (sham) group, and Group-III as the Resveratrol group. Arthritis was induced by intradermal injection of chicken type II collagen combined with incomplete Freund9s adjuvant. One day after the onset of arthritis, resveratrol (20 mg/kg/day) was given via oral gavage, until they were killed on day 29. Animals were sacrificed at the 15th day after the onset of arthritis. The paws of the rats were obtained for further analysis. Perisynovial inflammation and cartilage-bone destruction were determined histopathologically in the paws. Tissue Wnt-5a, axin-2, DKK1, mitogen-activated protein kinase (MAPK), Src tyrosine kinase and signal transducer and activator of transcription-3 (STAT3) mRNA expressions were determined by real-time polymerase chain reaction (RT-PCR). <h3>Results</h3> Arthritis was clinically developed at 12 to 13 days after the injection of collagen (Fig. 1a). The 29th day scores were decreased in the paricalcitol and pyrvinium groups compared to the own 13th day score (p&lt;0.05 for both), while it was increased in the sham group (p&lt;0.05). Histopathological analysis demonstrated the extensive perisynovial inflammation and marked cartilage-bone destruction in sham group rats. Resveratrol treatment decreased the perisynovial inflammation and cartilage-bone destruction in the paws. Moreover, the tissue mRNA expressions of Wnt5a (11 folds), axin-2 (22 folds) and DKK1 (3 folds) were increased in the sham group compared to the control group (Fig. 1b-d). However, resveratrol treatment decreased their expressions. <h3>Conclusions</h3> The present study shows that Wnt signaling pathway is active in CIA model. Resveratrol inhibits Wnt pathway and ameliorates CIA. <h3>References</h3> Zou Y, et al. Mol Med Rep. 2015;12(5):7221–6. Liu H, et al. Stem Cells Int. 2016;2016:2524092. Kotha A, et al. Mol Cancer Ther. 2006;5(3):621–9. Zhong LX, et al. J Ovarian Res. 2015;8:25. <h3>Acknowledgement</h3> None <h3>Disclosure of Interest</h3> None declared
Influence of Stem Cell Mobilization After Cyclophosphamide, Thalidomide and Dexamethasone (CTD) Regimen in Patients with Newly Diagnosed Multiple Myeloma
Authors: Jae-Sook Ahn, Deok-Hwan Yang, Sung-Hoon Jung, Soo-Young Bae, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, Je-Jung Lee
Journal: Blood (2011)
Splenic and Circulating Human T Follicular Helper Cell Regulation By B Cell Depleting Therapy during Immune Thrombocytopenia
Authors: Sylvain Audia, Marzia Rossato, Maxime Samson, Malika Trad, Kim Santegoets, Alexandrine Gautheron, Olivier Facy, Pablo Ortega-Deballon, Laurent Martin, Marion Ciudad, Nona Janikashvili, Philippe Saas, Timothy Radstake, Bernard Bonnotte
Journal: Blood (2015)
The Effect Of CMV Reactivation On Relapse and Survival In Patients With AML and MDS After Allogeneic Stem Cell Transplant (allo-HCT)
Authors: Armin Ghobadi, Amir Hamdi, Piyanuch Kongtim, Denai Milton, Amin Alousi, Paolo Anderlini, Stefan O. Ciurea, Betul Oran, Issa Khouri, Simrit Parmar, Muzaffar H. Qazilbash, Partow Kebriaei, Uday R Popat, Katy Rezvani, Roy F Chemaly, Elizabeth J Shpall, Richard E Champlin, Qaiser Bashir
Journal: Blood (2013)
Effectiveness of somatostatin analogs plus prednisone in aggressive histotype and advanced stage of thymic epithelial tumors
Authors: M. Ottaviano, V. Damiano, L. Nappi, P. Rescigno, L. Montella, M. Marino, S. Del Vecchio, I. Tucci, C. von Arx, E. Matano, G. Palmieri
Journal: Annals of Oncology (2015)
Intact interferon-γ response against Coxiella burnetii by peripheral blood mononuclear cells in chronic Q fever
Authors: T. Schoffelen, J. Textoris, C.P. Bleeker-Rovers, A. Ben Amara, J.W.M. van der Meer, M.G. Netea, J.-L. Mege, M. van Deuren, E. van de Vosse
Journal: Clinical Microbiology and Infection (2016)
Effect of pirfenidone on mortality: pooled analyses and meta-analyses of clinical trials in idiopathic pulmonary fibrosis
Authors: Steven D Nathan, Carlo Albera, Williamson Z Bradford, Ulrich Costabel, Ian Glaspole, Marilyn K Glassberg, David R Kardatzke, Monica Daigl, Klaus-Uwe Kirchgaessler, Lisa H Lancaster, David J Lederer, Carlos A Pereira, Jeffrey J Swigris, Dominique Valeyre, Paul W Noble
Journal: The Lancet Respiratory Medicine (2016)
Interim Results for the Safety and Efficacy of Different Lenalidomide Starting Dose Regimens in Subjects with Relapsed or Refractory Chronic Lymphocytic Leukemia (CC-5013-CLL-009 Study)
Authors: Clemens Wendtner, Graeme Fraser, Stuart L. Goldberg, Adrian JC Bloor, Stephan Stilgenbauer, Florence Cymbalista, Thomas Kipps, Brendan Purse, Jennie Zhang, Jay Mei, Asher Chanan-Khan
Journal: Blood (2011)