tbuckley/cabot-search huggingface dataset:
Endoscopic full-thickness resection: the logical step toward more extended endoscopic oncologic resections?
Authors: Alexander Meining
Journal: Endoscopy (2015)

Few other disciplines have undergone a more dynamic development in the short-term history of medicine than flexible endoscopic surgery. Endoscopic polypectomy and mucosal resection successfully replaced the surgical resection of mucosal neoplasia – a major step in the reduction of trauma. Furthermore, the popularity of endoscopic submucosal dissection (ESD) is increasing because en bloc resections and the complete resection of larger lesions can be achieved with this technique. However, ESD is one of the most complex endoscopic procedures and remains challenging because of the long procedure time required and the relatively high risk for complications, including bleeding and perforation. For both of these complications, the “over-the-scope clip” (OTSC) system offers effective treatment. Therefore, now that we have the means to close iatrogenic perforations reliably [1], the next logical step is to perform full-thickness resections. Adequate specimens can be obtained for precise histopathologic assessment, as with laparoscopic wedge resection.
Abstract 3912: Comprehensive Characterization of SOX4 Protein Complexes in Prostate Cancer Cells
Authors: Yu-Heng Lai, Junmin Peng, Jessica Cheng, Carlos S. Moreno
Journal: Cancer Research (2010)

Abstract Title: Comprehensive Characterization of SOX4 Protein Complexes in Prostate Cancer Cells. Authors: Yu Heng Lai, Junmin Peng, Jessica Cheng, and Carlos S. Moreno Abstract: SOX4 is a developmental transcription factor in vertebrates that is required for differentiation and proliferation in multiple tissues. SOX4 is overexpressed in many human malignancies, but the precise role of SOX4 in cancer progression is still not well understood. Although it is known that SOX4 directly interacts with p53 and β-catenin, many of SOX4's protein binding partners remain unknown. Thus, the identification of additional SOX4 binding partners is essential for elucidating the mechanism of SOX4-mediated effects in cancer progression. We have adapted a one-step affinity purification method that allows rapid purification of via intracellular biotinylation of the amino-terminus of SOX4. We have transiently expressed SOX4 protein in LNCaP prostate cancer cells and purified SOX4 complexes with streptavidin-linked paramagnetic beads in order to perform large scale of proteomics analysis. We have identified several proteins that interact with SOX4 in vivo by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Details of these SOX4 protein-protein binding partners will be discussed. These proteomic data provide insights into the role of SOX4 in key pathways in cell proliferation, development, and cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3912.
Combination of Glucagon and Low-Dose Metoclopramide in Management of Cisplatin-Induced Nausea and Vomiting
Authors: M. BINDI, F. PEPI, L. SEBASTE, E. TUCCI, L. PIRTOLI
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Combination of Glucagon and Low-Dose Metoclopramide in Management of Cisplatin-Induced Nausea and Vomiting Get access MIRCO BINDI, MIRCO BINDI Department of Radiotherapy, University of SienaStr. del Mandorlo 17, 53100 Siena, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar FLORELLA PEPI, FLORELLA PEPI Department of Radiotherapy, University of SienaStr. del Mandorlo 17, 53100 Siena, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar LUCIO SEBASTE, LUCIO SEBASTE Department of Radiotherapy, University of SienaStr. del Mandorlo 17, 53100 Siena, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar ENRICO TUCCI, ENRICO TUCCI Department of Radiotherapy, University of SienaStr. del Mandorlo 17, 53100 Siena, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar LUIGI PIRTOLI LUIGI PIRTOLI Department of Radiotherapy, University of SienaStr. del Mandorlo 17, 53100 Siena, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 12, 17 August 1988, Page 973, https://doi.org/10.1093/jnci/80.12.973 Published: 17 August 1988
Treatment for the parents of feminine boys
Authors: L E Newman
Journal: American Journal of Psychiatry (1976)

Because extreme boyhood femininity is often a precursor of adult transsexualism, transvestism, and homosexuality, the author recommends early intervention for boys who meet specific behavioral criteria of gender disturbance. It is necessary to involve the parents in such treatment and to deal with the resistances they may have to recognizing and working on the problem as well as problems within the marital relationship that may affect the child's behavior. These boys are remarkably responsive to treatment given between the ages of 5 and 12, becoming more masculine in behavior and more comfortable with their identity as males.
FRI0246 Serious infusion-related reactions after rituximab in patients with rheumatoid arthritis: data from the autoimmunity and rituximab registry
Authors: J. H. Salmon, P. Ravaud, T. Bardin, P. Cacoub, A. Cantagruel, B. Combe, M. Dougados, R.-M. Flipo, B. Godeau, L. Guillevin, X. Le Loët, E. Hachulla, T. Schaeverbeke, J. Sibilia, I. Pane, G. Baron, X. Mariette, J.-E. Gottenberg
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To evaluate the prevalence of serious infusion-related reactions after rituximab (RTX) in a large prospective registry of patients with rheumatoid arthritis. <h3>Methods</h3> The Autoimmunity and Rituximab registry (AIR) is an independent registry promoted by the French Society of Rheumatology that included 1983 patients with rheumatoid arthritis treated with rituximab and followed-up prospectively for seven years. An infusion-related reaction (IRR) was defined as occurring during or in the 24 hours following an infusion. <h3>Results</h3> Overall, 45 IRR resulted in RTX discontinuation [2.2% of all patients with RA, 0.4% of all infusions]. These serious IRR occurred after the first cycle in 17 patients, the second cycle in 18, the third cycle in 7, the fourth cycle in 2 patients and after the fifth cycle in 1 patient. Serious IRR mainly occurred after the first infusion of the cycle (71% of the 45 IRR vs 39% after the second infusion). 32 patients (73%) had allergic or anaphylactic manifestations such as a skin rash (18 patients), a throat irritation (8 patients), an anaphylaxis (3 patients), a bronchospasm (2 patients) or an angioedema (1 patient), 5 (11%) hypertension, 3 patients (7%) fever, 4 patients (8.5%) other symptoms and 1 missing data. Among the 30 patients who had a serious IRR after the second or subsequent infusions, 15 (50%) had previously had a milder IRR requiring a transient interruption or a reduction in the infusion flow. There was no fatal infusion-related reaction, and all infusion-related reactions resolved after discontinuation of RTX and symptomatic treatment. <h3>Conclusions</h3> The real life frequency of IRR resulting in RTX discontinuation is similar to that observed in clinical studies, approximately 0.5 %. Allergic manifestations were the most frequent. These reactions mainly occurred during the first two cycles, but nearly a quarter of them occurred after the 3d or subsequent cycles. Last, severe reactions had been preceded by a milder infusion reaction to a former infusion in 50% of patients <b>Disclosure of Interest</b>: None Declared
FRI0490 The four finger examination technique is superior to the standard two finger technique to detect metacarpal phalangeal joint swelling in rheumatoid arthritis - a validation by power doppler ultrasound
Authors: E. C. Keystone, M. A. Omair, P. Akhaven, A. Naraghi, D. A. Weber, J. Xiong, S. Mittoo, M. L. Weber
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Swollen joints (SJs) are a strong clinical predictor of radiographic progression in rheumatoid arthritis (RA). The metacarpal phalangeal joints (MCP) SJs are particularly relevant since they are the earliest joints demonstrating radiographic progression. Thus, more sensitive detection of less obvious SJs is important for improved assessment of disease activity. A novel four finger (FF) examination technique was developed to be more sensitive than the two finger (TF) technique in the detection of less clinically apparent joint swelling. <h3>Objectives</h3> To compare the sensitivity of the FF vs. TF technique to detect synovitis by ultrasound (US). <h3>Methods</h3> We compared the FF vs. TF examination technique in 180 MCPs in 18 RA patients. The population was comprised of 94.4% females, mean age of 55.8 yrs and mean disease duration of 19.9 yrs. Patients were examined twice on the same day by 4 rheumatologists; 2 performed FF and 2 used the TF technique. SJs were determined by palpation defined by being either (1) ballotable or (2) spongy (non-ballotable swelling). TJs were also assessed. We evaluated the agreement between the SJ/TJ examination techniques with US using grey scale, power Doppler (PD) positivity, or the presence of an effusion. <h3>Results</h3> Consistent with previous literature, the inter-observer agreement (IA) using Kappa statistics was poor to moderate for both SJ techniques. We therefore evaluated only joints in which there was agreement between the 2 examiners for each SJ technique. With the TF and FF techniques respectively, there were 115 &amp; 134 SJs in which there were agreement for the joints being ballotable and 99 &amp; 122 SJs for being spongy. The Kappa agreement between FF and TF techniques respectively, for ballottement by PD was 0.55 vs 0.27; by grey scale 0.35 vs. 0.12, and by effusion: 0.18 vs. 0.08. For SJ detected by being spongy, the relationship between FF and TF was the same, but the Kappas were lower. The agreement between TJs and US was extremely poor with mean Kappas for the 4 examiners for PD of 0.07; for grey scale: 0.06 and for effusion: -0.08. <h3>Conclusions</h3> The results of this study demonstrate that for MCPs, the FF technique is more sensitive than the TF technique for detection of synovitis as determined by US and therefore a better examination technique for clinical decision making. Of significance, the data provide strong support for the importance of detecting SJs (rather than TJs) as a prognostic guide for structural damage in RA. <h3>Disclosure of Interest</h3> None Declared
Abstract 795: Patterns of T-cell distribution at the invasive margin of colorectal cancer liver metastases: Downstream recruitment of T cells and spatial heterogeneity
Authors: Niels Halama, Inka Zoernig, Anna Spille, Peter Schirmacher, Karsten Brand, Christine Falk, Niels Grabe, Dirk Jäger
Journal: Cancer Research (2011)

Abstract The local immunological cancer microenvironment influences the clinical course of colorectal cancer. The interface between colorectal cancer liver metastases and adjacent normal liver represents a clear border. Typically, T cells in the vicinity of the tumor are located on the stromal compartment of the tumor and only few cells are in direct contact with the tumor epithelium. Patterns of T cell distribution at the invasive margin are heterogeneous and have not been analyzed systematically. Using high-throughput whole slide imaging technology, tissue areas of 1 mm2 size were analyzed for precise T cell density and localization, showing distinct density patterns of localization in relation to the malignant tissue across the invasive margins of samples from different patients. Unsupervised clustering revealed distinct patterns: regions with T cells in close contact to the tumor usually had significantly elevated T cell numbers further away from the tumor, whereas the other groups showed limited enrichment. Additionally, in the distance of around 20 to 40 µm from the tumor a decrease in T cells was found. The distribution of the cells in the tissues could be accounted for by cell-matrix interactions, immune cell – immune cell interactions or chemotactic fields potentially generated by tumor or other cells. Direct T cell – tumor interaction however leads to subsequent far-reaching attraction and activation of T cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 795. doi:10.1158/1538-7445.AM2011-795
Oral Manifestations of Crohn's Disease
Authors: T Stricker, C P Braegger
Journal: New England Journal of Medicine (2000)

Figure 1. An eight-year-old girl had a four-month history of painful mouth lesions, resulting in decreased oral intake and weight loss, and a one-year history of intermittent abdominal pain and irregular bowel movements. On examination, she had cheilitis, redness and swelling of the gingiva, and oral ulcerations (Panels A and B), as well as tenderness of the right lower quadrant and a perianal fissure. Colonoscopy with multiple biopsies revealed findings consistent with the presence of Crohn's disease. Five weeks after the initiation of treatment with 40 mg of oral prednisone daily (2 mg per kilogram of body weight), the patient's . . .
Pancreatico-gastric anastomotic insufficiency successfully treated with endoscopic vacuum therapy
Authors: T. Schorsch, C. Müller, G. Loske
Journal: Endoscopy (2013)

We carried out an adapted Kausch–Whipple operation with gastro-pancreatic anastomosis in a 65-year-old male patient with duodenal adenocarcinoma (pT3, pN0, M0, R0). On postoperative day 2 we observed substantial discharge of air and biliary fluid from the perianastomotic drain. Initial endoscopy showed a semicircular dehiscence of the pancreatico-gastric anastomosis ([Fig. 1]). The postpyloric anastomosis was intact. There was no general abdominal guarding in the spontaneously breathing and hemodynamically stable patient.
Cytokine Receptors in Congenital Hematopoietic Disease
Authors: Jeffrey S. Flier, Lisa H. Underhill, Alan D. D'Andrea
Journal: New England Journal of Medicine (1994)

Hematopoietic growth factors promote both growth and differentiation of blood cells1,2. These factors activate specific hematopoietic growth factor receptors that are expressed on the surface of blood progenitor cells of the bone marrow. The past decade has witnessed the identification and cloning of several genes for hematopoietic growth factors and growth factor receptors. The availability of the complementary DNA encoding these polypeptides has provided tools for understanding the normal process of blood-cell production and the abnormal processes of leukemia and other diseases in humans.Hematopoietic Growth FactorsThe identification of hematopoietic growth factors was made possible primarily by . . .
Radiofrequency ablation for the treatment of radiation proctitis
Authors: Xavier Dray, Gorgio Battaglia, Dov Wengrower, Pedro Gonzalez, Alessandra Carlino, Marine Camus, Tomer Adar, Francisco Pérez-Roldán, Philippe Marteau, Alessandro Repici
Journal: Endoscopy (2014)

<b>Background and study aims: </b>The main endoscopic therapy for radiation proctitis is argon plasma coagulation (APC); however treatment is not always successful. Radiofrequency ablation (RFA) is a possible treatment for radiation proctitis but data are scarce. The aim of this study was to report on the safety and efficacy of RFA in the treatment of radiation proctitis. <b>Patients and methods:</b> This study was an open-label, retrospective, multicenter study of patients with chronic hemorrhagic radiation proctitis who were treated with RFA. Data included a three-item symptom score, the number of packed red blood cell transfusions, the lowest hemoglobin concentration, and complications, during the 6 months prior to and after RFA. Clinical success was defined as a decrease in the symptom score. Biological success was defined as an increase in the hemoglobin rate with equal or decreased number of transfusions required. <b>Results:</b> A total of 17 patients underwent a median of 2 RFA sessions (range 1 – 4), without perioperative complications. Symptom scores decreased in 16 patients (clinical success 94 %), from a mean score of 3.6 (median 4) to 1.4 (median 1) (<i>P</i> < 0.01). Two patients developed rectal ulceration, with no local symptoms. During the 6 months after RFA, hemoglobin concentration increased in all 17 patients (from mean 8.3 ± 2.8 g/dL [median 7.5] to 11.3 ± 2.2 g/dL [median 11.0]; <i>P</i> < 0.01). Among 13 patients who were transfusion dependent prior to RFA (mean 7.2 ± 7.7 transfusions [median 4]), 9 patients (69 %) were weaned off transfusions after RFA. A significant increase in the hemoglobin level was observed in this subgroup of patients (from mean 7.2 ± 1.4 g/dL [median 7.3] to 10.7 ± 1.5 g/dL [median 10.5]; <i>P</i> < 0.001). Biological success was 100 %. <b>Conclusions:</b> RFA seems to significantly decrease clinical symptoms and increase the hemoglobin concentration, thus reducing the need for transfusions.
Epstein-Barr virus-associated B-cell lymphoproliferative disorder in a patient with Sézary syndrome treated by methotrexate
Authors: S. Ingen-Housz-Oro, N. Ortonne, N. Cordel, J. Moroch, G. Do-Pham, M.H. Delfau, C. Haioun, O. Chosidow
Journal: British Journal of Dermatology (2016)
Abstract P1-09-03: Chemoprevention in patients with newly diagnosed breast cancers
Authors: AP Refinetti, J Chun, F Schnabel, A Guth, D Axelrod
Journal: Cancer Research (2012)

Abstract Background: Chemoprevention (including tamoxifen, raloxifene, and exemestane) is a strategy to reduce breast cancer incidence in high risk women. Studies have shown at least a 50% decrease in the incidence of breast cancer in users of these drugs. Despite this benefit, the majority of high risk, unaffected women who are offered chemoprevention decline the therapy. However, there is a growing population of women who have used these agents for primary prevention, and a larger population of survivors who have used these drugs as part of their systemic treatment. The purpose of this study was to identify a cohort of women with newly diagnosed breast cancers who had utilized chemoprevention and describe their patterns of disease. Methods: The Breast Cancer Database of NYU Langone Medical Center was queried for patients who used chemopreventive drugs and developed breast cancer between 1/2010-1/2012. Patients were divided into primary and secondary chemoprevention groups (no previous history of breast cancer and previous history of breast cancer, respectively). Descriptive statistics were utilized. Results: In the study period, 24 (2%) of 996 patients had used a chemopreventive agent. For 16 of the 24 (67%), the drug was part of systemic therapy for prior breast cancer, with a median of 12 years from the initial diagnosis to the diagnosis of a second breast cancer. The primary chemoprevention group included women with risk based on family history and atypical hyperplasias. The majority of patients were diagnosed with early stage disease (88% DCIS and stage I). This likely reflects their screening behaviors. In both groups, the majority of cancers were ductal in origin. Five of the 8 patients in the primary chemoprevention group were on treatment at the time of their cancer diagnosis, while 63% of patients in the secondary group were prior users. In the secondary group, the majority of cases were contralateral second primary breast cancers, with 31% ipsilateral recurrences. Interestingly, the majority of cancers in both groups were ER/PR positive. Conclusions: Our cohort of women who used chemoprevention drugs were overwhelmingly diagnosed with early stage breast cancer, likely reflecting their commitment to screening. The majority of cancers were ER/PR positive. In this group, the choice of cancer treatment will need to be modified in light of prior hormonal treatment. Many of the patients in the secondary group were past users of prevention agents and further work is needed to clarify the duration of benefit of these drugs. In a similar vein, we look forward to research efforts to define the optimal age to initiate primary chemoprevention in high risk women. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-09-03.
Cardioversion of Atrial Fibrillation
Authors: Bernard Lown, Mark G. Perlroth, Sami Kaidbey, Tadaaki Abe, Dwight E. Harken
Journal: New England Journal of Medicine (1963)

ATRIAL fibrillation is one of the most prevalent of the chronic rhythm disorders of the heart. It is a derangement with serious implications. Even when the patient is asymptomatic the arrhythmia is by no means innocuous. The increased tendency to atrial mural-thrombus formation threatens the propagation of systemic and pulmonary emboli. Between one quarter and one third of all patients with atrial fibrillation due to disease of the mitral valve experience clinically recognizable embolic events. Atrial fibrillation also impairs cardiac performance. This is especially likely in the heart already compromised by disease.The method of terminating atrial fibrillation has . . .
Efficacy and safety of Endoscopic Ultrasound guided fine needle aspiration biopsy (EUS FNAB) in gastrointestinal and mediastinal disease
Authors: SO Riordan, E Clarke, F Gleeson, S Sengupta, DO Donovan, N Mulligan, J Lennon, P Macmathuna
Journal: Endoscopy (2006)

Background: Management of GI malignancy is determined by accurate staging (TNM) using CT, MRI and PET. These modalities have limitations with regard to tumour stage, local extension and the differentiation of benign and malignant adenopathy, which may be overcome by EUS / EUS FNAB. Aim: To assess the technical success, the diagnostic yield and complications of EUS FNAB. Method: 61 patients were referred for EUS FNAB for the evaluation of suspected or confirmed upper gastrointestinal, pancreaticobiliary and mediastinal malignancy. All patients had CT / MRI evaluation of disease prior to EUS FNAB. Results: Tissue was acquired in 97% (59/61) of cases with an average of 2 needle passes. Diagnostic yield was 84% (51/61) – Table 1. Mediastinal nodes / mass 21 Pancreatic mass, nodes, ascites 31 GI Tract primary lesions 9 Transient chest pain occurred in 2 patients following mediastinal biopsy. Nodal and ascitic fluid FNAB significantly upstaged disease and influenced management. Conclusion: EUS FNAB is a safe and effective modality for tissue diagnosis of upper gastrointestinal and thoracic benign and malignant disease.
358 REDUCED FGF19 LEVEL IN BILE AND DECREASED FGF19 EXPRESSION IN THE GALLBLADDER OF PATIENTS WITH PRIMARY SCLEROSING CHOLANGITIS
Authors: S.J.L.B. Zweers, A. Shiryaev, T.H. Karlsen, P.L.M. Jansen, F.G. Schaap
Journal: Journal of Hepatology (2012)
DECELERATION TIME OF EARLY DIASTOLIC MITRAL ANNULAR VELOCITY AS A NEW INDEX FOR NONINVASIVE ASSESSMENT OF LEFT VENTRICULAR END-DIASTOLIC PRESSURE
Authors: Takeshi Hozumi, Kazushi Takemoto, Kumiko Hirata, Makoto Orii, Akio Kuroi, Takeyoshi Kameyama, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Takashi Kubo, Atsushi Tanaka, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2016)