tbuckley/cabot-search huggingface dataset:
Panel Discussion: Role of the Knowledge of High Risk Groups in Occupational Health Policies and Practices
Authors: Michael Wright, D. Jack Kilian, Nicholas A. Ashford, Paul Kotin
Journal: Environmental Health Perspectives (1979)

This conference includes people from many scientific disciplines and people concerned primarily with policy issues. None of us are experts in all of those areas. Many of us may have felt that one session or another at this conference was out of our field of interest. That's an unfortunate situation, because more and more, we're going to have to start making links between the science and the policy. Those who are concerned primarily with occupational health policy are going to have to gain a detailed knowledge of the science. Those who are in scientific research have to begin to recognize the policy implications of the work. Certainly, all of us have to have a commitment to pursuing both the science and the policy as honestly and objectively as we can. Finally, and most important, all of us have to begin to make this knowledge accessible to people who are directly concerned-workers in the mines and mills and factories and labs and everywhere else. They are the ones whose health and whose jobs are on the line. They should be the ones to make the decisions. All of us have the responsibility to see that we communicate with them in an honest and effective manner. Let me explain my biases. In the Steelworker's Safety and Health Department we are concerned with the health of our members and of all working people and we are concerned with the economic livelihood of our members and all working people. We don't think our members or anyone else should have to choose between those things. In the past, a lot of our people have been told that they do have to choose between those things. There are plenty of examples of companies claiming they will have to shut down if they are forced to meet OSHA standards: in other words, they're saying  money or your life. So, if some of us are a little worried by
789 SERUM INTERLEUKIN-6 LEVELS DURING TREATMENT CORRELATE WITH RESISTANCE TO TELAPREVIR-BASED TRIPLE THERAPY IN CHRONIC HEPATITIS C
Authors: Y. Asahina, M. Nakagawa, M. Taniguchi, F. Kawai, J. Fujiki, T. Otani, H. Yamanaka, M. Murakawa, S. Nitta, A. Kitazume, T. Watanabe, Y. Sakurai, S. Azuma, S. Kakinuma, M. Watanabe
Journal: Journal of Hepatology (2013)
Discordant Uptake on Ga-67 and Tc-99m MDP Scintigraphy in a Patient with Multiple Myeloma
Authors: TONG LI, JACK FARINHAS, K. J. CHUN, LEONARD M. FREEMAN
Journal: Clinical Nuclear Medicine (2003)

LI, TONG M.D.; FARINHAS, JACK M.D.; CHUN, K. J. M.D.; FREEMAN, LEONARD M. M.D. Author Information
WATCHFUL OBSERVATION VERSUS EARLY AORTIC VALVE REPLACEMENT FOR SYMPTOMATIC LOW-GRADIENT SEVERE AORTIC STENOSIS WITH PRESERVED EJECTION FRACTION: A MULTICENTER COHORT STUDY
Authors: Duk-Hyun Kang, Jeong Yoon Jang, Sung-Ji Park, Dae-Hee Kim, Jong-Min Song, Seung Woo Park, Kee-Joon Choi, Joo-Hee Zo, Jae-Kwan Song, Jae Won Lee
Journal: Journal of the American College of Cardiology (2015)
Overview: the female physician and her marriage
Authors: M F Myers
Journal: American Journal of Psychiatry (1984)

Previous research has addressed the marital problems of male but not female physicians. The author reviews the literature on women in medicine, reports findings on 16 female physicians with dysfunctional marriages whom he saw as patients, and describes several problem areas: delayed help seeking, self-blaming attitude toward subjective symptoms, ambiguity in self-image, "passivity" in marital communication, role strain, unmet needs in husbands, bilateral competitiveness, and problems with intimacy and sexuality. The author emphasizes a biopsychosocial approach to treatment and discusses transference-countertransference issues.
ASSOCIATION BETWEEN DAILY GLUCOSE FLUCTUATION AND CORONARY PLAQUE PROPERTIES IN PATIENTS RECEIVING LIPID-LOWERING THERAPY ASSESSED BY CONTINUOUS GLUCOSE MONITORING AND OPTICAL COHERENCE TOMOGRAPHY: A PROSPECTIVE OBSERVATIONAL STUDY
Authors: Masaru Kuroda, Toshiro Shinke, Kazuhiko Sakaguchi, Hiromasa Otake, Tomofumi Takaya, Yushi Hirota, Tsuyoshi Osue, Hiroto Kinutani, Akihide Konishi, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Yuto Shinkura, Natsuko Tahara, Koji Kuroda, Daiji Kashiwagi, Keisuke Nagasawa, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2015)
Risk factors that may modify the innate and adaptive immune responses in periodontal diseases
Authors: Ellie T. Knight, Jenny Liu, Gregory J. Seymour, Clovis M. Faggion, Mary P. Cullinan
Journal: Periodontology 2000 (2016)

Abstract Plaque‐induced periodontal diseases occur in response to the accumulation of dental plaque. Disease manifestation and progression is determined by the nature of the immune response to the bacterial complexes in plaque. In general, predisposing factors for these periodontal diseases can be defined as those factors which retain or hinder the removal of plaque and, depending upon the nature of the immune response to this plaque, the disease will either remain stable and not progress or it may progress and result in chronic periodontitis. In contrast, modifying factors can be defined as those factors that alter the nature or course of the inflammatory lesion. These factors do not cause the disease but rather modify the chronic inflammatory response, which, in turn, is determined by the nature of the innate and adaptive immune responses and the local cytokine and inflammatory mediator networks. Chronic inflammation is characterized by vascular, cellular and repair responses within the tissues. This paper will focus on how common modifying factors, such as smoking, stress, hormonal changes, diabetes, metabolic syndrome and HIV/AIDS, influence each of these responses, together with treatment implications. As treatment planning in periodontics requires an understanding of the etiology and pathogenesis of the disease, it is important for all modifying factors to be taken into account. For some of these, such as smoking, stress and diabetic control, supportive health behavior advice within the dental setting should be an integral component for overall patient management.
PWE-178 Feasibility, safety and efficacy of endoscopic resection of upper gastrointestinal submucosal lesions in a western setting: Abstract PWE-178 Table 1
Authors: P J Basford, R J Mead, M D Duku, G R Longcroft-Wheaton, P Bhandari
Journal: Gut (2012)

<h3>Introduction</h3> Submucosal lesions are a relatively common finding at upper gastrointestinal endoscopy. Endoscopic resection (ER) may be warranted in larger lesions, those causing symptoms or those with malignant potential. However submucosal origin makes these lesions difficult to resect by an endoscopic approach. Advances in resection techniques have made this feasible. <h3>Methods</h3> Portsmouth Hospitals is a tertiary referral centre for advanced ER. All ER procedures between 2005 and 2011 were recorded in a prospective database. We analysed our database to identify all submucosal lesions removed by ER in the past 7 years. All procedures were carried out by a single skilled endoscopist. Demographic data, histology, procedure success, long-term outcome and complications were assessed. <h3>Results</h3> A total of 161 lesions were treated by UGI ER between 2005 and 2011. 14 of 161 were submucosal lesions. Nine of the 14 patients were female and the mean age was 54.3 years (range 34–69 years). Five lesions were located in the oesophagus, seven in the stomach and two in the duodenum. Histology revealed granular cell tumour (3), neuroendocrine tumour (5), inflammatory fibroid polyp (2), lipoma (2), gastrointestinal stromal tumour (1), Leiomyoma (1). All cases were successfully treated in a single ER session of which 6 cases were treated by conventional EMR, 9 by ESD techniques. The single complication was a microperforation during ESD of an oesophageal GIST which was endoscopically clipped. The patient was managed conservatively with intravenous antibiotics and was discharged after 3 days. There were no cases of significant bleeding and no patient required surgery. After a mean follow-up of 19.5 months all patients remain well and have no signs of recurrence. <h3>Conclusion</h3> The caseload of UGI ER for submucosal lesions in low with an average of two cases per year in a large UK specialist centre. The majority of cases required ESD skills and therefore these cases should be treated in specialist centres with expertise in this technique. Outcomes and complication rates were acceptable in this small series and major surgery was avoided in these patients reducing costs and bed occupancy. <h3>Competing interests</h3> None declared.
Abstract 2663: SPECT/CT analysis of distribution of intracranially infused interleukin-13 <i>Pseudomonas</i> exotoxin, a targeted agent for interleukin-13 receptor expressing brain tumors.
Authors: Akiko Suzuki, Pamela Leland, Peter L. Choyke, Tomio Inoue, Bharat H. Joshi, Raj K. Puri
Journal: Cancer Research (2013)

Abstract Interleukin-13 Pseudomonas exotoxin (IL-13PE), a powerful targeted agent for IL-13 receptor α2 (IL-13Rα2) - positive tumors is being tested for safety and effectiveness in glioblastoma multiforme (GBM) clinical trials. However, distribution of IL-13PE after intra-cranial convection-enhanced delivery (CED) has not been determined. To study this, we radiolabeled IL-13PE with 125I and determined its binding and biological activity in vitro and distribution in a murine model of GBM. 125IL-13PE maintained its specific binding activity to IL-13Rα2 positive U251 glioblastoma tumor cells but not to T98G cells, as these cells did not express IL-13Rα2. 125IL-13PE was as cytotoxic to glioblastoma cells as non-radiolabeled IL-13PE, which killed U251 tumor cells in a concentration dependent manner but not T98G cells. Both binding and cytotoxic activities were blocked by a 100-fold excess of IL-13, which indicated that IL-13PE binding was specific. Athymic nude mice with intracranially implanted U251 tumors were given stereotactic intratumoral injections of 125I-IL-13PE by either a bolus injection or a 3-day-CED. Animals were imaged by micro-SPECT/CT at various time points. SPECT/CT imaging revealed retention of 125I-IL-13PE in U251 tumors. CED showed significantly higher volumes of distribution and maintained detectable drug levels for longer periods of time compared to bolus injection. SPECT/CT images of whole brains corroborated with the autoradiography results performed on sectioned brain. These results indicate that IL-13PE can be successfully radiolabled with 125I without the loss of binding and cytotoxic activity and that 125I-IL-13PE administered by CED showed higher volumes of distribution than the bolus route. Thus, future clinical studies with 125I-IL-13PE or other agents should consider the CED mode of delivery for better distribution in intracranial environments. Volume of distribution of 125I-IL-13PE after bolus or CED administration into mouse brain Injection parameters SPECT Time Vi (μl)* Vd (mm3)** Vd:Vi ratio Bolus - day 1 10 minutes 5 10.2 ± 0.4 204.7 ± 7.0 Bolus - day 7 10 minutes 5 0.1 ± 0.02 2.0 ± 0.4 CED - day 1 3 days 100 120.4 ± 21.8 120.4 ± 21.6 CED - day 7 3 days 100 81.7 ± 6.9 81.7 ± 6.7 *Vi: Volume of injection **Vd: Volume of distribution Citation Format: Akiko Suzuki, Pamela Leland, Peter L. Choyke, Tomio Inoue, Bharat H. Joshi, Raj K. Puri. SPECT/CT analysis of distribution of intracranially infused interleukin-13 Pseudomonas exotoxin, a targeted agent for interleukin-13 receptor expressing brain tumors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2663. doi:10.1158/1538-7445.AM2013-2663
PTU-062 Significant response to local ablative bridging treatments facilitates acceptable rates of survival following liver transplantation for HCC in a UK centre
Authors: R Lochan, R Coates, J French, H reeves, B Jaques, S White, D Manas
Journal: Gut (2012)

<h3>Introduction</h3> Liver Transplantation (LT) is a well-recognised treatment option for selected patients with hepatocellular carcinoma (HCC). However there is always concern regarding tumour progression while on the waiting list. As yet there is no agreed consensus on how to reduce progression of disease while waiting. UK guidelines recommend local ablative therapy for all HCC patients being considered for LT. We have sought to review this practice and evaluate its benefit. <h3>Methods</h3> All consecutive patients with HCC who have undergone LT between 2001 and 2010 were identified from our prospectively maintained database. All patients are discussed at our LT assessment meeting and also at a separate HPB MDT for consideration of bridging treatment. Our imaging protocol includes (1) triple phase CT to assess the number of hyper vascular liver lesions, presence of venous washout, or extra-hepatic disease, (2) MRI to re-characterise any atypical lesions or (3) CEUS for further characterisation. Patients undergo either trans-arterial chemo-embolisation (TACE) and/or percutaneous/laparoscopic radio frequency ablation (RFA) while on the LT waiting list. The response to bridging treatment is assessed and intensive surveillance for disease progression is also undertaken. <h3>Results</h3> 55 HCC patients underwent LT (M:F=43:12), Childs-Pugh A (n=9), B (n= 30) and C (n=16). Bridging treatments were either TACE n=31, RFA n=28, or both treatments n=4. TACE treatments per patient were 1 (n=12), 2 (n=12), 3 (n=6) or 4 (n=1). Six patients did not undergo any form of bridging treatment as they rapidly progressed to LT. The response to bridging treatment was complete (n=8), good (n=28), poor (n=4) or no response (n=15). There were two deaths within 100 post-operative days. At last follow-up, 28 patients had died due to recurrent disease, stable recurrent disease n=4 or disease free n= 21. Overall survival [median (95% CI)] was 62 (53–71) months. For those with a good response to bridging treatments it was 67 (55–79) months while for those with poor/no response it was 53 (42–64) months (log-rank p=0.059). <h3>Conclusion</h3> This study demonstrates the feasibility of various bridging treatments for patients with HCC who await liver transplantation in the UK. In combination with careful patient selection and surveillance acceptable rates of survival can be achieved. <h3>Competing interests</h3> None declared.
OUTCOMES IN PATIENTS TREATED WITH TICAGRELOR OR CLOPIDOGREL AFTER ACUTE CORONARY SYNDROME: EXPERIENCES FROM SWEDEHEART REGISTRY
Authors: Anders Sahlén, Christoph Varenhorst, Bo Lagerqvist, Henrik Renlund, Elmir Omerovic, David Erlinge, Lars Wallentin, Stefan James, Tomas Jernberg
Journal: Journal of the American College of Cardiology (2016)
Abstract 2234: Circulating tumor cells are rare in patients with curable oligometastatic cancer
Authors: Daniel J. Boffa, Xiaojie Guo, Annette Molinaro, Betsy Finan, Frank Detterbeck, David L. Rimm
Journal: Cancer Research (2010)

Abstract Background: In the majority of patients with solid organ malignancies, tumor metastasis marks a transition from curable to terminal. However, a subset of metastatic cancer patients develops only a very limited number of metastases (known as oligometastatic). Survival in this cohort is considerably better than patients with widely disseminated cancer. In fact, in highly select subgroups, as many as 30% of oligometastatic patients are actually cured of cancer. The mechanism that distinguishes limited (or oligometastatic) cancer, from the more lethal, widely disseminated, is unknown. Tumor cell circulation is a critical component of metastasis formation, with circulating tumor cells being detectable in as many as 40-70% of patients with metastatic cancer. We hypothesize that patients with limited metastasis formation, have limited tumor cell circulation. To test this hypothesis, we quantified circulating tumor cells in patients with oligometastatic disease. Methods: Circulating tumor cells (CTCs) were quantified in patients with metastatic epithelial malignancies using the Veridex assay. Patients with &amp;gt; 2 CTCs in a 7.5 ml specimen were considered positive, as a single CTC has previously been shown to carry a substantially higher false positive rate (6.4%) than &amp;gt;2 CTCs (.3%). Results: From April 2008 to December 2009, a total of 20 patients with oligometastatic cancer were enrolled. In all patients the primary tumor had been previously removed and each was being evaluated for curative surgery to remove the oligometastatic cancer. The origin of the primary tumor was colon (17 patients), head and neck (1 patient), ovarian (1 patient), and pancreas (1 patient). The site of oligometastatic cancer was the liver (12 patients), lungs (4 patients) or both liver and lungs (4 patients). Only 1 of the 20 patients with oligometastatic cancer (5%) was found to have &amp;gt;2 circulating tumor cells. During the same time frame, CTCs were more common in patients with disseminated cancer as 4 of 7 patients (57%) with incurable, widely disseminated metastatic cancer had &amp;gt; 2 CTCs (two tailed P value = .0089). Conclusions: Circulating tumor cells are rare in patients with oligometastatic cancer. One mechanism by which oligometastatic cancer patients avoid more widely disseminated cancer may relate to the frequency and duration of tumor cell circulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2234.
UTILIDAD DE LA PAAF GUIADA POR ULTRASONOGRAFÍA ENDOSCÓPICA EN EL DIAGNÓSTICO DE TUMORES NEUROENDOCRINOS
Authors: S Maisterra, J Gornals, C Pons, M Varas, M De la Hera, I Catalá, T Serrano, D Bargalló, N Peláez, J Fabregat
Journal: Endoscopy (2010)

Objetivo: Los tumores neuroendocrinos (TNE) constituyen una patología poco frecuente. El objetivo del estudio fue evaluar la precisión diagnóstica de la punción aspirativa con aguja fina guiada por ultrasonografía endoscópica (USE-PAAF) en la confirmación citológica de los TNE con estudio inmunocitoquímico.
Studies must have policies on feeding back health related findings to participants, says new guidance
Authors: S. Mayor
Journal: BMJ (2014)

Researchers carrying out studies involving human participants in the United Kingdom must have clear policies on whether or not health related findings will be fed back to participants, new guidance has recommended.

There is currently intense debate about whether and how health related findings from human studies, such as identifying a brain tumour during a brain imaging study or an elevated risk of Alzheimer’s disease in a genome-wide study in diabetes, should be fed back to …
P93 Social risk factors associated with tuberculosis in a high incidence area of the UK: Abstract P93 Table 1.
Authors: WM Ricketts, LF Anderson, VLC White
Journal: Thorax (2013)

<h3>Introduction</h3> The London Borough of Newham consistently has the highest incidence of tuberculosis (TB) in the UK (≈120/100,000), with case numbers continuing to rise. We sought to investigate social risk factors for TB as compared with the general population in this borough. <h3>Methods</h3> Of 242 adult patients diagnosed with TB in 2012 at the Newham Chest Clinic 170 (70.3%) completed a structured interview assessing for social risk factors. Demographic data was obtained from hospital records. TB case data was compared with 2011 census data using Fisher’s exact test or t-tests as appropriate. <h3>Results</h3> Data directly comparable to 2011 census data is summarised in Table 1. Cases had a mean of 3.43 (95% CI 3.07–3.8) household contacts, 2.28 (1.41–3.16) non-household family contacts and 2.02 (1.71–2.33) close friends. Household and family contacts were almost exclusively of the same ethnicity as the cases, but with 18.4% of household contacts and 49.2% of family contacts being UK born, compared with 7.7% of cases. The majority of friends were of the same ethnicity (86%) with 18.4% UK born, 89.4% of cases had no close friends from a different ethnic group. None of the cohort reported alcohol or drug abuse or had been in prison in the last 5 years, one was currently homeless. Fifteen (8.8%) reported recent visitors from abroad and 61 (38.9% of foreign born) reported returning to their country of birth for greater than three weeks, with 75.4% having returned within the last two years, a further eleven had travelled to a high incidence country in the last ten years, six of whom were UK born travelling to their parents’ country of birth. <i>Conclusions </i>In this high incidence area of an otherwise low incidence country TB is significantly more common in those of South-Asian birth and ethnicity. It is more common in young adults who have lived in the UK between two and five years and work in unskilled jobs or are unemployed. This picture is likely driven by TB reactivation in new immigrants accompanied by a lack of social mixing and suggesting the influence of relative poverty in the development of TB.
Imaging of a Mediastinal Thymic Carcinoid Tumor With Radiolabeled Somatostatin Analogue
Authors: DANIEL G. CADIGAN, PETER D. HOLLETT, PETER W. COLLINGWOOD, EHUD UR
Journal: Clinical Nuclear Medicine (1996)

A patient underwent imaging with In-111 DTPA (Octreotide) as part of investigation for MEN-1 syndrome and possible therapy with nonradioactive somatostatin. Uptake of radionuclide correlated to an anterior mediastinal mass seen on CT, biopsy specimens proved it to be a thymic carcinoid. Very few nuclear images of these lesions have been published in the literature. This is another example of the use of somatostatin analogue imaging in endocrine neoplasia.
Aortic Graft Infection Diagnosed on a Tc-99m HMPAO Leukocyte Scan
Authors: David M Stark, David Cline, Gerald Longa, Bashar Kashlan, Lowell Houpt, Dennis Cavanaugh
Journal: Clinical Nuclear Medicine (2002)

STARK, DAVID M. B.S.,*; CLINE, LCDR DAVID MC, USN,†; LONGA, GERALD M.D.,†; KASHLAN, BASHAR M.D.,†; HOUPT, LOWELL C.N.M.T.†; CAVANAUGH, DENNIS M.D.† Author Information
GENETIC RISK SCORES PREDICT RECURRENCE OF ACUTE CORONARY SYNDROME
Authors: Satu Vaara, Emmi Tikkanen, Olavi Parkkonen, Marja-Liisa Lokki, Samuli Ripatti, Markus Perola, Markku S. Nieminen, Juha Sinisalo
Journal: Journal of the American College of Cardiology (2016)
Fatal and Near-Fatal Anaphylactic Reactions to Food in Children and Adolescents
Authors: Hugh A. Sampson, Louis Mendelson, James P. Rosen
Journal: New England Journal of Medicine (1992)

Reports of fatal or near-fatal anaphylactic reactions to foods in children and adolescents are rare. We identified six children and adolescents who died of anaphylactic reactions to foods and seven others who nearly died and required intubation. All the cases but one occurred in one of three metropolitan areas over a period of 14 months. Our investigations included a review of emergency medical care reports, medical records, and depositions by witnesses to the events, as well as interviews with parents (and some patients).