tbuckley/cabot-search huggingface dataset:
Differential ability of mutant H-RAS and mutant K-RAS to enhance radiation-induced signaling and cell survival
Authors: Ruben Caron, Adly Yacoub, Michael P. Hagan, Steven Grant, Paul Dent
Journal: Cancer Research (2004)

1297   Previous studies have shown that ionizing radiation causes activation of ERBB1 and downstream signaling pathways in carcinoma cells in two waves: the first wave as an initial response to radiation exposure, the second due to the autocrine actions of TGF alpha. We have examined the impact, in an isogenic background, of mutant active H-RAS and mutant active K-RAS on the expression of autocrine growth factors, ERBB family receptors, radiation-induced activation of downstream signaling pathways and radiation-induced reduction of clonogenic survival. HCT116 cells, wild type and mutant K-RAS deleted, were transfected with vector control and mutant H-RAS plasmids, respectively. Clones were isolated and studied. Deletion of mutant K-RAS enhanced expression of ERBB1 and ERBB3, and expression of mutant H-RAS further enhanced ERBB1 and ERBB3 levels. Deletion of mutant K-RAS abolished expression of epiregulin whereas expression of mutant H-RAS enhanced expression of heregulin without restoring epiregulin expression. The levels of TGF alpha and HB-EGF remained approximately constant. Radiation caused phasic activation of ERK1/2 and AKT in wild type cells that were abolished in mutant K-RAS deleted cells. The introduction of mutant H-RAS into mutant K-RAS deleted cells restored basal and radiation-stimulated ERK1/2 and AKT activation, which in the case of AKT, was greater than that observed in wild type cells expressing mutant K-RAS. Mutant H-RAS cells had a higher plating efficiency and were more radio-resistant than wild type cells. Thus loss of mutant K-RAS expression and introduction of mutant H-RAS promoted increased expression of ERBB3 and its ligand heregulin that correlated with enhanced AKT activation and elevated radio-resistance. Thus mutant RAS isoforms may differentially alter the ability of cells to respond to irradiation by altering the levels of ERBB receptors, their ligands and the activation downstream signaling pathways.
T-Cells with Extremely Short Telomeres and High Telomerase Activity in T-Cell Prolymphocytic Leukemia (T-PLL): The Ideal Target for Telomerase Inhibition.
Authors: Alexander Roeth, Jan Duerig, Heike Himmelreich, Reiner Siebert, Stefanie Bug, Ulrich Duehrsen, Peter M. Lansdorp, Gabriela Baerlocher
Journal: Blood (2006)
Rituximab maintenance for the Treatment of patients with Follicular Lymphoma: Systematic Review and Meta-Analysis of Randomized Trials - 2010 Update.
Authors: Liat Vidal, Anat Gafter-Gvili, Gilles Salles, Martin H. Dreyling, Michele Ghielmini, Shu-Fang Hsu Schmitz, Ruth Pettengell, Mathias Witzens-Harig, Ofer Shpilberg
Journal: Blood (2010)
SAT0573 Validity of The Short Form 6d Utility Measure in Early Axial Spondyloarthritis: Results from The Desir Cohort
Authors: C. Gaujoux-Viala, L. Gossec, M. Dougados, J.-P. Daurès
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The quantification of health improvements is essential, notably in the current context of increasingly expensive therapies and more and more limited resources. Preference-based measures of health have become important for estimating health states in calculating quality-adjusted life years (QALYs), an essential component of cost-utility analysis. The SF-6D is an indirect preference-based health-related quality of life instruments increasingly being used for economic evaluation of clinical interventions and health programs. Data on economic as well as QoL outcomes among early axial Spondyloarthtritis (axSpA) patients remain scarce. <h3>Objectives</h3> To evaluate the validity of an utility measure, the SF-6D, in early axSpA especially concerning the ability of this measure to reflect the change in patients9 condition over time. <h3>Methods</h3> DESIR (Devenir des Spondyloarthropathies Indifférenciées Récentes) is a French, multicentre, longitudinal cohort of 708 patients with early inflammatory back pain suggestive of axSpA. SF-6D utility measures were assessed in 607 patients over 1 year. To investigate whether the change in SF-6D is a valid measure of change in axSpA health status, we used Spearman9s product-moment correlation to compare change scores for SF6D with those for external measures of health, the HAQ, SF36 physical component, SF36 mental component and AS-QOL from baseline to 6 and 12 months. Responsiveness was tested by the effect size (ES) at 6 and 12 months for the entire sample and subgroups by disease evolution (increase or decrease-stabilization in BASDAI). Bootstrap methods were used to estimate 95% confidence intervals [95% CI]. Sensitivity to change of the HAQ was calculated as a benchmark. <h3>Results</h3> At baseline, mean value of SF-6D was 0.69±0.12 (range 0.30 to 0.95). The distribution was near normal. Few missing values were observed: 2.4%. No floor or ceiling effects were evidenced. Correlations of the SF6D change with change in HAQ and physical component of SF-36 scores were moderate at 6 months (r=-0.42 and 0.44, respectively). Correlations with change in mental component of SF-36 and AS-QOL scores were good (r=0.60 and -0.60, respectively). Correlations were stable over 1 year. For the entire sample at 6 months, the SF-6D was more sensitive to change than the HAQ: ES 0.36 [95% CI 0.28;0.44] versus -0.22 [-0.28;-0.17]. The SF-6D was more responsive than the HAQ for improved condition: ES 0.45 [0.37;0.54] vs -0.32 [-0.38;-0.26] without difference for patients with deteriorated condition: ES SF-6D -0.23 [-0.41;-0.04] vs 0.33 [0.18;0.50] for HAQ. Results were similar at 12 months. <h3>Conclusions</h3> The SF-6D is valid and able to reflect the change in patients9 condition over time, especially improvement, in patients with early inflammatory back pain suggestive of axSpA. <h3>Disclosure of Interest</h3> None declared
Abstract 018: Egg Consumption and Risk of Cardiovascular Disease: Findings from Three Large Prospective US Cohort Studies of Men and Women
Authors: Amanda L Sands, Deirdre K Tobias, Meir J Stampfer, Walter C Willett, Frank B Hu
Journal: Circulation (2013)

Background: Limiting dietary cholesterol intake is widely recommended for prevention of cardiovascular disease (CVD). Eggs are a major source of dietary cholesterol, but they also contain a variety of other nutrients. Several recent studies have examined egg intake and CVD with conflicting findings. Objective: To prospectively evaluate the association between egg intake and CVD risk in three large cohorts. Methods: Women and men from the Nurses’ Health Study (1980-2010; N=84,537), Nurses’ Health Study II (1991-2010; N=92,588), and Health Professionals Follow-up Study (1986-2010; N=42,815) were included if they were free of CVD and cancer at baseline. Egg intake was assessed every 4 years via validated food frequency questionnaire and evaluated in the following categories for frequency of consuming 1 egg: &lt;1/month (reference), 1-3/month, 1/week, 2-4/week, 5-6/week, 1+/day. Incident coronary heart disease (CHD) (nonfatal myocardial infarction (MI) and fatal coronary disease) and stroke cases were ascertained via self-report and confirmed with review of medical records. Relative risks (HR) and 95% confidence intervals (CI) for CVD risk across categories of egg intake were estimated using multivariate Cox proportional hazards models, adjusted for age, race, smoking, physical activity, BMI, family history of CVD, alcohol, red and processed meat, whole milk, and other dietary covariates. Individual cohort estimates were combined using fixed effects meta-analysis. Results: We identified 5,838 incident cases of CHD (nonfatal MI and fatal CHD) and 6,030 stroke cases. Consumption of up to 1+eggs/day was not significantly associated with risk of incident total CVD (CHD and stroke) after adjustment for several diet and lifestyle factors (HR (CI) by category: &lt;1/month: 1(reference); 1-3/month: 0.95(0.88, 1.02); 1/week: 0.85(0.79, 0.91); 2-4/week: 0.88(0.81, 0.96); 5-6/week: 0.96(0.84, 1.09); 1+/day: 0.99 (0.87, 1.13) (p-trend=0.77). When incident stroke and CHD were evaluated individually, egg intake was not associated with either endpoint (p-trend=0.09 for CHD and 0.52 for stroke). Conclusions: After controlling for lifestyle and dietary factors, egg intake (up to 1+/day) was not associated with increased risk of CVD in three prospective cohorts of men and women.
Relationship Of Serum Free Light Chain Reduction To Best Overall Response In Phase 2 Single-Agent and Combination Studies Of Carfilzomib In Patients With Relapsed Or Relapsed and/Or Refractory Multiple Myeloma
Authors: Ravi Vij, Michael Wang, Sundar Jagannath, Ruben Niesvizky, Andrzej J. Jakubowiak, Edward Kavalerchik, Mei Huang, David S. Siegel
Journal: Blood (2013)
The Relevance of Minimal Residual Disease (MRD) Monitoring in Elderly Multiple Myeloma (MM) Patients
Authors: Bruno Paiva, Teresa Cedena, Noemi Puig, Lourdes Cordon, Joaquin Martinez-López, Enrique M. Ocio, Miguel T Hernandez, Ana Isabel Teruel, Mercedes Gironella, M Asuncion Echeveste, Laura Rosiñol, Rafael Martinez, Albert Oriol, Jesus Martin, Norma C Gutiérrez, Maria Belen Vidriales, Joan Blade, Juan Jose Lahuerta, Maria-Victoria Mateos, Jesus San Miguel
Journal: Blood (2015)
Non-Random Integration and Clone Selection by Lentiviral SIN-LTR Vectors.
Authors: Cynthia C. Bartholomae, Annette Deichmann, Manfred Schmidt, Rafael J. Yanez-Munoz, Steven J. Howe, Sonja Schmidt, Claudia Prinz, Adrian J. Thrasher, Christof von Kalle
Journal: Blood (2006)
Cardiac Toxicity and Non-Relapse Mortality in Patients with Low Left Ventricular Ejection Fraction Undergoing Stem Cell Transplantation.
Authors: Diem T. Chu, Rima Saliba, Suhail Qureshi, Amin Alousi, Paolo Anderlini, Farhan Bukhari, Marcos Delima, Sergio A. Giralt, Partow Kebriaei, Issa F. Khouri, Gaurav Parik, Uday Popat, Elizabeth J. Shpall, Wamique S. Yusuf, Richard E. Champlin, Muzaffar H. Qazilbash, Chitra Hosing
Journal: Blood (2007)
Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A/C Mutation Carriers
Authors: Saurabh Kumar, Samuel H. Baldinger, Estelle Gandjbakhch, Philippe Maury, Jean-Marc Sellal, Alexander F.A. Androulakis, Xavier Waintraub, Philippe Charron, Anne Rollin, Pascale Richard, William G. Stevenson, Ciorsti J. Macintyre, Carolyn Y. Ho, Tina Thompson, Jitendra K. Vohra, Jonathan M. Kalman, Katja Zeppenfeld, Frederic Sacher, Usha B. Tedrow, Neal K. Lakdawala
Journal: Journal of the American College of Cardiology (2016)
Autologous Hematopoietic Stem Cell Transplantation Versus Intravenous Pulse Therapy Cyclophosphamide for Severe or Rapidly Progressive Systemic Sclerosis, the Astis Trial
Authors: Farge Dominique, Jaap Van Laar, Jacob K Sont, Kamran Naraghi, Zora Marjanovic, Jerome Largero, Annemie Schuerwegh, Erik W.A. Marijt, Madelon Vonk, Anton Schattenberg, Marco Matucci, Irene Miniati, Alexandre Voskuyl, Arjan A. Van de Loosdrecht, Thomas Daikeler, Ina Koetter, Marc Schmarlzing, Thierry Martin, Stefan Weiner, Christophe Deligny, jean Marc Durand, Paul Emery, klaus P Machold, Françoise Sarrot-Reynauld, Klaus Warnatz, Daniel Adoue, Joel Constans, Hans-Peter Tony, Nicoletta Del Papa, Athanasios Fassas, Andrea Himsel, David Launay, Andrea Lo Monaco, Pierre Philippe, Isabelle Quere, Eric Rich, Rene Westhovens, Bridget Griffiths, Riccardo Saccardi, Frank H Van Den Hoogen, Willem E. Fibbe, Gerard Socie, Alois Gratwohl, Alan Tyndall
Journal: Blood (2012)
Lip b 1 is a novel allergenic protein isolated from the booklouse, <i>Liposcelis bostrychophila</i>
Authors: O. Ishibashi, K. Sakuragi, Y. Fukutomi, Y. Kawakami, Y. Kamata, M. Sakurai, S. Nakayama, H. Uchiyama, H. Kobayashi, H. Kojima, T. Inui
Journal: Allergy (2016)

Abstract Background Booklice, belonging to the order Psocoptera, are small household insect pests that are distributed worldwide. Liposcelis bostrychophila , a common home‐inhabiting species of booklouse, infests old books, sheets of paper, and stored food. Recent entomological and serological studies demonstrated that L. bostrychophila accounted for the majority of detectable insects in house dust and could be a potent inducer of respiratory allergy. Our recent proteomic analysis identified a potent allergenic protein from L. bostrychophila , designated Lip b 1, and determined its partial amino acid sequences. Methods Cloning of c DNA s for Lip b 1 was performed by large‐scale transcriptome analysis ( RNA ‐seq) and subsequent reverse transcription polymerase chain reaction. The full‐length amino acid sequences deduced from Lip b 1 cDNA s were bioinformatically analyzed. The recombinant proteins of glutathione S ‐transferase ( GST )‐fused Lip b 1 were analyzed by Western blot and enzyme‐linked immunosorbent assay. Results Lip b 1 c DNA s encoding two types of 254‐amino acid proteins were cloned. The clones shared 87% identity, and the deduced molecular weights and isoelectric points were consistent with those determined in our previous study. The two types of Lip b 1 proteins in the GST ‐fused form were similarly reactive with sera from allergic patients sensitized with L. bostrychophila . Conclusions Lip b 1 is a novel protein possibly causing booklouse allergy.
AB0612 Multicenter Registry on Inflammatory Myopathies in Madrid (REMICAM): Descriptive Analysis
Authors: L. Nuño, M.J. García, F.J. Lόpez Longo, V. Maldonado, I. Llorente, C. Barbadillo, P. García de la Peña, L. Ruiz, H. Moruno, T. Cobo, R. Almodovar, L. Lojo, B. Joven
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Clinical manifestations, evolution and prognosis of idiopathic inflammatory myopathies (IIM) are very heterogeneous which, together with its low prevalence, limits the study of the disease. <h3>Objectives</h3> To analyze the clinical characteristics of patients diagnosed of IIM in a multicenter study. <h3>Methods</h3> A multicenter retrospective descriptive study from REMICAM<sup>1</sup> myositis study group was performed. All patients were diagnosed with IIM according to Bohan and Peter<sup>2</sup> criteria, were followed up sometime between January 1980 and December 2014 and were classified into 7 different clinical subgroups: primary dermatomyositis (DM), primary polymyositis (PM), juvenile dermatomyositis (JuvM), cancer associated myositis (CAM), overlap myositis (OM), inclusion body myositis (IBM) and necrotizing myositis (NM). <h3>Results</h3> 478 IIM cases were included. 74% of the cases was women, with an age at diagnosis of 43.7±22.6 years, and an average follow-up time of 9.7±8.3 years. The main IIM subgroups were primary myopathies (PM 28%, DM 22%, OM 19.9%, JuvM 19.2%, CAM 8.4%, NM 1.3%, BMI 1.3%). The connective tissue diseases more frequently associated in OM subgroup were MCTD (30%), systemic sclerosis (27%) and SLE (18,9%). The main extramuscular manifestations were cutaneous lesions (65%), arthritis (43%), general symptoms (39%) gastrointestinal complications (33%), and interstitial lung disease (ILD) (30%). Patients with OM had a higher prevalence of ILD (46.8% vs. 25.8%;p&lt;0.001), Raynaud (67% vs. 19.4%;p&lt;0.001), arthritis (70% vs. 35.8%;p&lt;0.001) and cytopenias (55.9% vs. 21.5%; p&lt;0.001), whereas JuvM patients developed more calcinosis (30.4% vs. 5.7%;p&lt;0.001) but fewer serious infections (4.7% vs. 29.3%;p&lt;0.001). During the period of study 114 patients died (24%), and the main causes of death were infections (24%), cancer (24%) and cardiovascular events (22%). <h3>Conclusions</h3> In this multicenter REMICAM registry 478 IIM cases have been included. The most common subtypes were primary myopathies, and the most frequent extramuscular manifestation were typical cutaneous lesions. Overlap myositis patients presented with more extramuscular manifestations than the other subgroups. <h3>References</h3> REMICAM: Registry on inflammatory myopathies from Madrid Bohan A, Peter JB. N Engl J Med 1975 Feb 13;292(7):344–7. <h3>Disclosure of Interest</h3> None declared
PTH-136 Gender Differences in Leadership, Workforce, and Scholarly Presentation within A National Society; A Gastroenterology Perspective
Authors: AJ Brooks, EA Arthurs, C Edwards, R Gardner, MJ Lockett, P Neild, J Solomon, EJ Taylor, S Thomas-Gibson, J Eaden
Journal: Gut (2016)

<h3>Introduction</h3> In the UK, gastroenterology historically has been a male predominant medical speciality, but specific data regarding the outcomes of gender within workforce, academia and leadership at a national level are lacking. <h3>Methods</h3> Data regarding scholarly presentation at the British Society of Gastroenterology (BSG) 2013, 2014, 2015 annual conferences were collected and analysed. In 2015 this included member societies for Digestive Diseases Federation (DDF). Data from the 2013–2015 BSG annual workforce report were examined. <h3>Results</h3> In 2015 female higher speciality trainees made up 39% (328/850) of the trainee workforce, compared to 37% and 35% in 2014 and 2013 respectively. From 2013–2015 the proportion of female academic trainees has been 22%, 23% and 24% respectively. In the years from 2013–2015, less than a fifth (18%) of all consultant gastroenterologists were female. Female consultant (18%), trainee (39%), associate (86%) and student attendance (47%) at DDF 2015 did not change significantly from 2013–2014. The number of female speakers 43/331 (13%) was significantly lower at DDF 2015 compared with BSG 2014 56/212 (26.4%) (<i>P</i> = 0.0001) and BSG 2013 63/231 (37%) (<i>P</i> = 0.0001). The number of female chairs did not differ between the annual conferences; 23/173 (13%) in 2015, 20/94 (21%) in 2014, 29/118 (25%) in 2013, nor did delivery of the named lectures; 2/15 (13%) in 2015, and 1/6 (17%) in both 2014 and 2013. Prizes (oral, poster, ‘Dragon’s Den) awarded to females was 44%, 30% and 20% respectively, and did not differ significantly in 2013/2014. Female leadership at the BSG via representation at Council and Executive was 4/30 (13%) in 2015, and did not differ in 2013/2014, with no <i>elected</i> council members since 2008 and 1 female president in 1973. <h3>Conclusion</h3> The proportion of female gastroenterology trainees and consultants is increasing, but remains lower than across all medical specialties at 52% and 34% respectively.<sup>1</sup> Female attendance and scholarly presentation at conferences reflects the workforce. Lower numbers of female speakers at DDF 2015 may reflect differences in surgical and allied specialties. Action within the BSG is underway to address female underrepresentation in leadership roles. Strategies to encourage female recruitment and retention to gastroenterology are being tested and evaluated. <h3>Reference</h3> 1 Census of consultant physicians and higher speciality trainees in the UK, 2014–2015. RCP, 2016. <h3>Disclosure of Interest</h3> None Declared
Rituximab (R) + Hypercvad Alternating with R-Methotrexate/Cytarabine after 9 Years: Continued High Rate of Failure-Free Survival in Untreated Mantle Cell Lymphoma (MCL)
Authors: Jorge Romaguera, Luis Fayad, Alma Rodriguez, Fb Hagemeister, Barbara Pro, Peter McLaughlin, Anas Younes, Felipe Samaniego, Jatin Shah, Pamela Weaver, Kim Hartig, Fernando Cabanillas, Larry Kwak, Hagop Kantarjian, Michael Wang
Journal: Blood (2008)
Genetic Polymorphisms Associated with Clinical Outcome in the Intergroup Trial S9321, Comparing High Dose Therapy with Standard Dose Therapy for Myelomaon, on Behalf of ECOG, SWOG, CALGB, and the Bank on a Cure.
Authors: Rafael Santana-Davila, John Crowley, Brian Durie, Bart Barlogie, Philip Greipp, Brian Van Ness
Journal: Blood (2004)
Abstract 3512: Measuring intracellular target engagement and drug residence time with nanoBRET
Authors: Matthew B. Robers, Melanie Dart, Chad Zimprich, Thomas Kirkland, Sergiy Levin, Thomas Machleidt, Jim Hartnett, Kris Zimmerman, Rachel Ohana, Danette Daniels, Mei Cong, Frank Fan, Keith Wood
Journal: Cancer Research (2015)

Abstract We present a biophysical method to directly measure target engagement within intact mammalian cells using bioluminescence energy transfer (BRET). Compound interactions with intracellular targets can be detected with complete specificity by their ability to compete with energy transfer complexes introduced into the cells. These complexes can be detected at physiologically relevant levels by exploiting an extraordinarily bright luciferase (NanoLuc), together with fluorescent tracers optimized for cell-permeability and spectral resolution from the luciferase. We demonstrate applications of the technology for target engagement among key drug target classes, including; kinases, histone deacetylases (HDACs), bromodomains, and the methyltransferase EZH2. Intracellular selectivity and affinity profiles of various reference compounds and approved drugs will be presented. For a panel of HDAC inhibitors, affinity profiles for specific HDAC isozymes strongly correlate with phenotypic potencies (e.g. cell viability). Furthermore, the luminescent output of the energy transfer complex enables a technique to monitor ligand occupancy in real-time. Association and dissociation rates can be derived from the kinetic measurements, providing a means to quantify drug residence time on select targets within intact cell populations. This novel application of intracellular BRET should significantly advance target engagement work flows, and allow for intracellular target affinities to be coupled to phenotypic outcomes. Citation Format: Matthew B. Robers, Melanie Dart, Chad Zimprich, Thomas Kirkland, Sergiy Levin, Thomas Machleidt, Jim Hartnett, Kris Zimmerman, Rachel Ohana, Danette Daniels, Mei Cong, Frank Fan, Keith Wood. Measuring intracellular target engagement and drug residence time with nanoBRET. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3512. doi:10.1158/1538-7445.AM2015-3512
THU0554 Polymorphisms of Transient Receptor Potential Vanilloid (TRPV) 2 and Trpv3 Gene Polymorphisms Were Associated with fibromyalgia in A Korean Population
Authors: J.-H. Kang, D.-J. Park, S.-H. Kim, S.-S. Nah, J.H. Lee, S.-K. Kim, Y.-A. Lee, S.-J. Hong, H.-S. Kim, H.-S. Lee, H.A. Kim, C.-I. Joung, S.-H. Kim, S.-S. Lee
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Objectives</h3> Researchers continue to gather evidence that transient receptor potential vanilloid (<i>TRPV</i>) channels contribute towards pain signaling pathways. However, it is unknown whether polymorphisms of the <i>TRPV</i> gene are associated with fibromyalgia (FM). For the first time, we investigated the association between the polymorphisms of the <i>TRPV2</i> and <i>TRPV3</i> genes with FM susceptibility and the severity of the symptoms. <h3>Methods</h3> A total of 409 patients with FM and 423 controls were enrolled from 10 medical centers that participated in the Korean nationwide FM survey. The alleles and genotypes at three positions [rs3813768 (C&gt;G), rs8121 (C&gt;T), and rs1129235 (C&gt;A)] in the <i>TRPV2</i> gene, and two positions [rs7216486 (G&gt;A) and rs395357 (C&gt;T)] in the <i>TRPV3</i> gene, were genotyped. <h3>Results</h3> The frequencies of the alleles and genotypes of individual <i>TRPV2</i> and <i>TRPV3</i> genes were not significantly associated with FM susceptibility. However, the GTA haplotype of <i>TRPV2</i> showed a defense against FM susceptibility (<i>P</i>=0.035). In addition, polymorphisms of <i>TRPV3</i> were associated with symptom severity in FM patients. The single nucleotide polymorphism (SNP) rs395357 of <i>TRPV3</i> was associated with the scores of the Brief Fatigue Inventory (BFI) (<i>P</i>=0.017) in FM patients. Furthermore, haplotypes of <i>TRPV3</i> were associated with the BFI and the SF-36 mental health summary scores (<i>P</i>=0.036, respectively) <h3>Conclusions</h3> This study was the first to evaluate the associations of <i>TRPV</i> gene polymorphisms with FM. Our results suggest that certain <i>TRPV2</i> haplotypes may have a protective role against FM, and also that some genotypes and haplotypes of <i>TRPV3</i> contribute towards the symptoms of FM. <h3>Disclosure of Interest</h3> None declared