tbuckley/cabot-search huggingface dataset:
Role of Implanted Inbred-Strain Thymic Tissue in the Development of Leukemia in F&lt;sub&gt;1&lt;/sub&gt; Hybrid Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: R RASK-NIELSEN
Journal: JNCI Journal of the National Cancer Institute (1958)

Two experiments attempting to elucidate the role of the thymus in the development of leukemia and a third experiment testing for the presence of a leukemogenic virus in leukemic cells were performed. Subcutaneous implantation of thymic tissue from mice of strains C57BL and DBA into (C57BL × DBA)F1 hybrids and from strain C57BL and C3H mice into (C57BL × C3H)F1 hybrids was followed in 3 to 4 weeks by injections of 0.02 mg. of 7,12-dimethylbenz[a]anthracene into the thymic grafts. No tumors appeared in the thymic grafts, and no influence on the incidence of leukemia in the hosts was observed. Subcutaneous implantation of thymic tissue from DBA/2 mice into (CBA × DBA/2)F1 hybrid mice showed no effect, whereas implantation of CBA thymic tissue into F1 hybrids of the same genetic constitution accelerated the development of leukemia in the hosts. No leukemic tumors were found in the thymic grafts. Leukemic tissue from DBA/2 mice was killed by X irradiation in vivo and injected intraperitoneally into (CBA × DBA/2)F1 mice. No influence on the incidence of leukemia was observed. In experiments 2 and 3, the incidence of leukemia in 213 (CBA × DBA/2)F1 mice over 18 months of age was about 50 percent. Most of the leukemias were of the plasma-cell variety; several of them and their transplantation lines showed abnormal serum-protein fractions in the β- or γ-globulin ranges. Several reticulosarcomatoses and localized reticulosarcomas, one atypical, presumably monocytic leukemia, and a number of leukemias, probably lymphatic, were observed.
Relationship Between Estrogen-Receptor Genotype and Tooth Loss in Postmenopausal Women
Authors: Akira Taguchi
Journal: JAMA (2001)

Tooth loss is known to be influenced by environmental factors, but the role of genetic factors remains unknown. It is likely that the estrogen-receptor (ER) gene could be associated with tooth loss in women because recent studies in the United State reported the protective effect of estrogen replacement therapy on tooth retention in the elderly. We first demonstrated relationship between ER genotype and tooth loss in post-menopausal women. However, further investigation is necessary to clarify unknown pathways in which ER genotype contributes to tooth loss in women.
SAT0249 Arterial Stiffness Interrelated with Axial Mobility but not with the Current Activity of the Disease in Patients with Ankylosing Spondylitis (Bechterew's Disease): Table 1.
Authors: I. Gaydukova, A.P. Rebrov, A.V. Aparkina, A.I. Akulova, O.A. Lebedinskaya, E.V. Khondkaryan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patients with ankylosing spondylitis (AS) have a higher cardiovascular morbidity and mortality compared with the general population [1]. Traditional methods of assessing cardiovascular risk not always reflect the real risk of cardiovascular disease, so it is important to look for clinical markers of cardiovascular risk related with musculoskeletal disorder. <h3>Objectives</h3> The goal of the present study is to establish the relationship between the rigidity of arterial wall, current activity parameters and the mobility of the spine in patients with ankylosing spondylitis without cardiovascular disease. <h3>Methods</h3> 91 patients, fulfilled to the modified New York criteria for AS, included in the study (age 41,89±12,36 year, disease duration 13,89±10,56 year, male – 49 patients). Patients with cardiovascular diseases and/or the presence of atherosclerotic plaques in carotids were excluded. Augmentation index (AixB) measured in the brachial artery, pulse wave velocity in the aorta (PWAo) (arteriograph Tensioclinik, Hungary). Ankylosing Spondylitis Disease Activity Score (ASDAS), the Bath AS Disease Activity Index (BASDAI), highsensitive C-reactive protein (CRP, mg/l) were determined as current activity parameters. Components of the Bath AS Metrology Index (BASMI) were taken into account as axial mobility parameters. For statistical analysis used SPSS17. <h3>Results</h3> Significant relationships were found between AixB and chest expansion (Spearmen9s R= -0.28, p=0.032), the tragus-wall distance (R= -0.44, p=0.001), the cervical rotation (R= -0.39, p=0.002), the lateral mobility of the lumbar spine (R= -0.29, p=0.03), the intermalleolar distance (R= -0.34, p=0.01), mSchober9s test (R= -0.39, p=0.02), and BASMI (R=0.38, p=0.04). PWAo was correlated with chest expansion (R= -0.36, p=0.006), the lateral mobility of the lumbar spine (R = -0.29, p=0.03), intermalleolar distance (R= -0.41, p=0.002), the BASMI (R=0.36, p=0.007). Statistically significant relationship between arterial stiffness parameters and current activity of AS parameters (CRP index BASDAI, index ASDAS) was not found, table1. <h3>Conclusions</h3> Arterial stiffness in ankylosing spondylitis patients without cardiovascular diseases is interralated with spinal mobility, but not with the current disease activity. <h3>References</h3> Lehtinen K. Ann Rheum Dis. 1993; 52:174-6. <h3>Disclosure of Interest</h3> None declared
PTU-298 Small bowel endoscopy: a 13-year experience of demand and outcomes
Authors: D Rattehalli, DS Sanders, ME McAlindon, K Drew, R Sidhu
Journal: Gut (2015)

<h3>Introduction</h3> Historically the small bowel has been considered a black box, which is technically difficult to examine due to its length, tortuosity and location. Diagnosis and management of small bowel pathology has entered a new era with the advent of capsule endoscopy (CE) and enteroscopy. We have been providing a comprehensive small bowel endoscopy service and we present our experience from the last 13 years, evaluating demand, diagnostic yield and management. <h3>Method</h3> A retrospective analysis was conducted on patients who underwent CE, push enteroscopy (PE), double balloon enteroscopy (DBE) and intraoperative enteroscopy (IOE) between January 2002 and October 2014. Data collected included demographics, indications, diagnosis, subsequent change in management and complications. <h3>Results</h3> A total of 4288 CEs, 294 PEs, 399 DBEs and 19 IOEs were performed over 142 months. The most common indication across all 4 modalities was obscure gastrointestinal bleeding (OGB). The majority of patients (91%) had CE prior to DBE or PE, which helped direct the route and modality of enteroscopy. The diagnostic yield for CE, PE, DBE and IOE were 29%, 43%, 49% and 89% respectively (p &lt; 0.0001). Whilst the demand for CE has continued to rise over the years (p &lt; 0.0001), the diagnostic yield has fallen (p &lt; 0.0001). The diagnostic yield was highest for the indication of OGB (36%) in CE compared to Crohn’s disease (30%, p &lt; 0.001). Significant pathology was found outside the small bowel in 8% of patients (colon 36%, gastric 64%). With the advent of DBE, the demand for PE has fallen (p = 0.03, r = -0.6) and was mainly used for proximal lesions seen on CE. In contrast, the demand for DBE has risen gradually in tandem with the diagnostic yield (p &lt; 0.0001, r = 0.9). Management was altered by CE in 25%, 43% for PE and 41% for DBE. The rate of therapeutics for PE and DBE were 21% and 24% respectively. In 2014, for every 13 CEs performed, one patient underwent DBE locally. Whilst there were no complications for PE, the complication rate for DBE was 1.25% and 10.5% for IOE. Capsule retention data was collected for patients undergoing CE from 2010. Of the 2882 procedures done in this period, CE retention &gt;2 weeks occurred in 6 patients (0.2%), of which 5 were due to a stricture (Crohn’s n = 4, non-steroidal n = 1) and 1 was due to delayed gastric emptying. Three patients required further intervention for capsule removal (endoscopic n = 2, surgery n = 1). <h3>Conclusion</h3> This is the largest series to date comparing the clinical utility of all four small bowel endoscopic modalities. Enteroscopy has an important role in altering management post CE in patients with small bowel pathology as reflected by the rising demand and yield. Future tariffs for the modalities particularly CE are likely to influence this demand. <h3>Disclosure of interest</h3> None Declared.
Quantities and Units in Clinical Chemistry.
Authors: R Dybkaer
Journal: Annals of Internal Medicine (1968)

HE COMMISSION ON CLINICAL CHESIIsTEY (CCC) of 1UPACt in 1965 nominated a Subeommission for Standards and Units ill Clinical Chemistry4 Concerning units, the primary task of the subcommission was to study (1) the individual and iiational efforts to counteract the increasingly chaotic use of quantities and units in clinical chemistry; (2) the current usage in related fields of science, especially biochemistry and general chemistry; and (3) the official recommendations from IUPAC, IUB, IUPAP,II and ISO.1T Secondarily, the subcommission was to submit a draft for a CCC Recommendation. An intermediate result, the pamphlet “A Primer of Quantities and Units in Clinical Chemistry (1966)” (1), was distributed among a number of national clinical chemical societies**_all the members of IFCCt f-and criticism was invited. At the Sixth International Congress of Clinical Chemistry in Munich in 1966, the contents were approved, with minor modifications, by CCC and IFCC. The preparation of a draft for the Recommendation 1966 of CCC and IFCC was left to B. Dybktr and K. J#{248}rgensen. The result was approved by the titular members of CCCI4 and forms part of a recently published, more comprehensive treatise (2). The Recommendation 1966 was finally accepted by the ITJPAC Section on Clinical Chemistry in Prague in 1967, and the future development was entrusted to
FRI0282 Experience of Biological Agents Treatment of Refractory Takayasu Arteritis in Children
Authors: Y. Kostina, G. Lyskina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Takayasu arteritis (TA) is a rare form of large vessel vasculitis characterized by granulematous inflammation. There are no controlled studies of medical treatment of children with TA. <h3>Objectives</h3> Tumor necrosis factor (TNF) and interlecinus-6 (IL-6) is the most important in the formation of granulomas. The granulomatous nature of the histopathologic lesion in TA led us to consider an evaluation of the therapeutic benefits of anti-TNF and IL-6 therapy in patients with refractory TA. In our study five children (5 girls) aged from 10 to 17 years with widespread inflammation in the aorta and its main branches were treated with infliximab and 1 girl was treated with tocilizumab during 12 months. The mean duration of the disease was 4.2 years. All patients received oral steroids and methotrexate or cyclophosphamide. The cause for biological treatment was standart therapy tolerance and uncontrolled arterial hypertension. Patients were tested for tuberculosis by skin test and chest roentgenography. Also we excluded active systemic infections, neutropenia, thrombocytopenia and liver dysfunction. <h3>Methods</h3> The efficacy of therapy was evaluated by inflammation markers – erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), fibrinogen, - clinical symptoms and results of doppler ultrasound. <h3>Results</h3> The success of 3 months biological therapy was evaluated according to the normal significances of ESP, CRP and lack of active disease symptoms, after 6 months – there were reduced of vessel wall thickness, after 12 months – clinical and laboratory remission. <h3>Conclusions</h3> In children with refractory TA infliximab and tocilizumab therapy was associated with remission and facilitating dose reduction of corticosteroids and other immunosuppressive treatment. The presented experience justifies a randomized, controlled clinical trial of anti-TNF and IL-6 treatment of TA in children. <h3>Disclosure of Interest</h3> None declared
PTH-158 The presence of perineural, blood and lymphvessel invasion after neoadjuvant therapy and oesophagectomy identifies high risk patients for recurrence
Authors: SM Lagarde, M Navidi, AW Phillips, B Disep, A Immanuel, M Griffin
Journal: Gut (2015)

<h3>Introduction</h3> In patients with oesophageal cancer, little attention has been paid to the relevance of tumour invasion in blood (AI) and lymphatic vessels (LVI) as well as perineural invasion (PNI) after neoadjuvant therapy. Therefore, the aim of the present study was to assess the incidence and prognostic significance of these factors in a consecutive series of patients with cancer of the oesophagus or gastro-oesophageal junction (GOJ) who underwent neoadjuvant therapy followed by oesophagectomy. <h3>Method</h3> From a prospectively collected database, a consecutive series of patients was analysed. All patients with potentially curable adeno- or squamous cell carcinoma of the oesophagus or GOJ were treated with neoadjuvant chemotherapy or chemoradiation therapy followed by transthoracic oesophagectomy and two-field lymphadenectomy. The presence of AI, LVI and PNI was prospectively collected. <h3>Results</h3> Between January 2000 and September 2013, a consecutive series of 396 patients underwent a potentially curative oesophagectomy after neoadjuvant therapy for adeno- or squamous cell carcinoma. AI was seen in 150 (38%) of patients, LVI was seen in 203 (51%) of patients and PNI was seen in 204 (52%) of patients. 123 (31%) had no AI, LVI or PNI whatsoever. 96 (24%) had a combination of two out of three factors and 94 (24%) had presence of AI, LVI and PNI. The presence of AI, LVI and PNI was significantly (P = 0.001) related with ypT- and ypN-stage. Median overall survival was 170.8 months (95% CI: 68.9–272.8) if AI, LVI and PNI were all absent, 44.0 months (95% CI: 20.9–67.2) when one factor was present, 27.1 months (95% CI: 22.8–31.4) when two factors were present and 16.0 months (95% CI: 9.4–22.6) when AI, LVI and PNI were all present. On multivariate analyses the presence of AI, LVI and PNI or a combination of these factors were independent predictors. <h3>Conclusion</h3> These findings suggest the importance of the presence of AI, LVI and PNI after neoadjuvant therapy followed by oesophagectomy. The presence of AI, LVI and PNI should be incorporated in the standardised pathology report. It provides additional information for identyfying patients at high risk who may be candidates for adjuvant therapies. <h3>Disclosure of interest</h3> None Declared.
AB0659 Characteristics of Neurological Manifestations of Behçet's Disease: About 60 CASES
Authors: N. Boughanmi, S. Boughanmi, A. Choker, N. Miladi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Behçet9s disease (BD) is a chronic multisystem inflammatory disorder wich can involve the central nervous system. Neurological involvement is one of the most devastating manifestations of BD. <h3>Objectives</h3> The purpose of this study was to describe epidemiological and clinical characteristics of neurological involvement in BD. <h3>Methods</h3> The medical notes of 60 patients with neuro-behçet9s disease (NBD) fulfilling the criteria of the international study group for BD were retrospectively reviewed. <h3>Results</h3> Sixty patients with NBD were studied. Their mean age was 31,8 years; 50 were men and 10 were women. Average disease duration of BD before neurological manifestations onset was 5,1 years. Parenchymal involvement occurred in 34 patients (56,66%) [brainstem: 13 (38,23%), hemispheric involvement: 10 (29,41%), aseptic meningitis: 8 (23,52%), spinal cord: 3 (8,82%)]. Non-parenchymal NBD occurred in 26 patients (43,33%). Involvement of the main vascular structures was the most common non-parenchymal NBD found in 20 patients (76,92%) consisting of cerebral vein thrombosis (CVT) in 16 cases and cerebral arterial thrombosis in 4 cases. The mean duration of follow up of patients with NBD was 5 years.Complete recovery or improvement with mild neurological impairement was seen in 34 cases,improvement with severe disability in 12 cases,worsening in 7 cases,the course was stationary in 4 cases and 3 patients died. <h3>Conclusions</h3> Clinical and epidemiological features of NBD are various.In our cohort, NBD occurred frequently in men and was more serious especially in parenchymal involvement. <h3>References</h3> Al-Araji A, Kidd DP. Neuro-Behçet9s disease: epidemiology, clinical characteristics, and management. Lancet Neurol. 2009;8(2):192-204. <h3>Disclosure of Interest</h3> None declared
THU0084 Can Autoantibody Level Changes Predict Arthritis in Arthralgia Patients?
Authors: M.V. Beers, M. Stuiver, M.D. Koning, L.V.D. Stadt, D.V. Schaardenburg
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> A preclinical phase of rheumatoid arthritis (RA) has been recognized in which abnormalities in autoantibodies exist, frequently accompanied by arthralgia. IgM rheumatoid factor (IgM-RF) and anti-citrullinated protein antibodies (ACPA) can be present many years before the diagnosis of RA, and blood donor cohorts show a rise in these markers 1-3 years preceding diagnosis. <h3>Objectives</h3> The present study was undertaken to develop individual prediction models using the autoantibody levels over time. <h3>Methods</h3> Data came from 263 patients in an ongoing prospective cohort of arthralgia patients with ACPA and/or IgM-RF positivity and with repeated measurements of ACPA and IgM-RF, who were followed for arthritis development. These patients were used to fit a joint model of IgM-RF/ACPA levels over time combined with time-to-event data for arthritis. <h3>Results</h3> Ninety-six patients (26%) developed arthritis after a median of 22 months (IQR 15-37). A total of 986 antibody measurements were included with a median number of 4 (IQR 3-5). The course of antibody levels over time was highly variable. On a group level, there was no statistically significant change of RF levels over time between the groups of patients who developed arthritis compared to those who did not. ACPA levels over time on the group level showed a small but statistically significant difference between the groups, with a rise of 10log transformed ACPA of 0.004 per month in the arthritis group and 0 per month in the patients who did not develop arthritis. The combination of longitudinally measured ACPA with time-to-event data for arthritis in the joint models showed a corrected hazard ratio of 2.6 (95%CI: 1.9-3.6, p&lt;0.001) for the development of arthritis, with an Area Under the Curve (AUC) of 0.769. However, when using only baseline levels of ACPA the AUC was 0.748. RF levels over time did not show any significant associations between the groups and in the joint models. <h3>Conclusions</h3> ACPA levels over time had limited additional predictive value over baseline measurement of ACPA levels only, while longitudinally measured RF had no predictive value for development of arthritis in seropositive arthralgia patients. The use of repeated antibody measurements for the individual prediction of arthritis development in the symptomatic at risk phase does not seem useful. <h3>Disclosure of Interest</h3> None declared
AB0633 A Very High Prevalance of Avascular Necrosis in Turkish Patients with Granulomatosis with Polyangiitis (Wegener's): Preliminary Results from a Single Centre: Table 1.
Authors: B. Toz, B. Erer, N. Alpay Kanıtez, B. Artım Esen, A. Gül, M. İnanç, L. Öcal, S. Kamalı
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Avascular necrosis (AVN) in ANCA associated vasculitides (AAV) is a rare finding of damage that has not been investigated in detail in terms of risk factors. <h3>Objectives</h3> To investigate the prevalance of AVN risk factors in patients with AAV <h3>Methods</h3> AAV cohort diagnosed according to CHCC, presented with ≥1 organ involvement, being followed-up and treated ≥6 months after diagnosis were included into the study. All symptomatic AVN was demonstrated by MRI. Demographic and clinical data including pre-defined AVN risk factors such as high BMI (≥25), hyperlipidemia, diabetes, smoking status, alcohol intake and cumulative glucocorticoid (GC) exposure were noted into a protocol. Initial BVAS and cumulative VDI were calculated in the majority of cohort. The patients were stratified in accordance to the presence of AVN (AVN+/AVN-). Demographics and AVN risk factors were compared between the groups by using Mann Whitney U test. <h3>Results</h3> The study group consisted of 129 AAV (16 e-GPA, 28 MPA, 85 GPA) patients (63 female) with the mean age at diagnosis 44±15 and mean follow-up time 60±46.7 (6-182) (med 48). Eighteen of 129 (14%) AAV patients developed AVN (2 MPA, 16 GPA). AVN was observed in knee (2), shoulder (1), hip (14) and ankle (1) and bilateral in 66%. Comparison of the AVN risk factors in AAV patients was shown in Table. <h3>Conclusions</h3> A very high prevalence of AVN was found in our GPA cohort, which is quite higher than the previously reported frequencies (&lt;1%). However, comparison of GC exposure data could not be done between our preliminary analysis and that of previously reported trial results. Other undefined risk factors to AVN such as variables affecting bone metabolism may contribute to observed differences warranting further investigations. Male gender has been identified as a new risk factor in our cohort, which has to be confirmed in large cohorts. <h3>Disclosure of Interest</h3> None declared
SAT0637-HPR Impairment in the Activities of Daily Living in Older Adults with and Without Osteoporosis, Osteoarthritis and Chronic Back Pain: Results of a Population-Based Cross-Sectional Study
Authors: T.A. Stamm, K. Pieber, J. Smolen, T. Dorner
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Independence in performing activities of daily living (ADLs) is a central aspect of functioning. Older adults frequently experience impairments and limitations in functioning in various life areas. <h3>Objectives</h3> The aim of this survey was to explore the limitations in the activities of daily living in older adults in a population-based survey in Austria. <h3>Methods</h3> 3097 subjects aged ≥65 years of the Austrian health interview survey formed the cohort of this analysis. Descriptive statistics were used to calculate frequencies of problems in the ADLs. A principal component analysis was applied to analyze the main dimensions of 19 items of ADL. Binary logistic regression models were used with the ADL dimensions as the dependent variables and osteoarthritis, chronic back pain, osteoporosis, sex, education level, anxiety or depression, age and pain intensity as independent variables. <h3>Results</h3> People with musculoskeletal conditions were significantly more often affected by ADL problems than people without these diseases. The ADL domain which caused problems in the highest proportion of people was "doing heavy housework" (43.9%), followed by "bending or kneeling down" (39.3%), "climbing stairs up and down without walking aids" (23.1%), and "walking 500 meter without walking aids" (22.8%). The principal components analysis revealed four dimensions of ADLs: (1) intense "heavy burden" ADLs, (2) basic instrumental ADLs, (3) basic ADLs and (3) hand-focused ADLs. The proportion of subjects who had problems with the respective dimensions was 58.2%, 29.2%, 23.0%, and 9.2%. Anxiety/ depression (greatest effect), followed by the chronic musculoskeletal disease itself, female sex, higher age and pain intensity were significant predictors of ADL problems. <h3>Conclusions</h3> This population-based survey indicates that older people have considerable ADL problems. Older adults with musculoskeletal complaints could be a special target group for ADL specialists such as physical medicine and rehabilitation physicians and occupational therapists. More attention should be paid to the high impact of pain intensity, anxiety and depression on ADLs. <h3>Disclosure of Interest</h3> None declared