tbuckley/cabot-search huggingface dataset:
Role of endoscopic ultrasonography in determining indications for endoscopic resection of early gastric cancer
Authors: Mandai Koichiro, Yasuda Kenjiro
Journal: Endoscopy (2011)

Endoscopic resection (ER) of early gastric cancer (EGC) is used for cases fitting criteria that predict minimal risk of lymph nodal metastasis: (1) well-differentiated adenocarcinoma (tub1) or moderately differentiated adenocarcinoma (tub2) limited to mucosa without ulcerative change (UL (-)); (2) tub1 or tub2 limited to mucosa with ulcerative change (UL (+)) (size, ≤30mm), (3) tub1 or tub2, with <500µm of submucosal invasion (sm1) (size, ≤30mm).
Interpersonal Psychotherapy for Mental Health Problems: A Comprehensive Meta-Analysis
Authors: Pim Cuijpers, Tara Donker, Myrna M. Weissman, Paula Ravitz, Ioana A. Cristea
Journal: American Journal of Psychiatry (2016)

Objective: Interpersonal psychotherapy (IPT) has been developed for the treatment of depression but has been examined for several other mental disorders. A comprehensive meta-analysis of all randomized trials examining the effects of IPT for all mental health problems was conducted. Method: Searches in PubMed, PsycInfo, Embase, and Cochrane were conducted to identify all trials examining IPT for any mental health problem. Results: Ninety studies with 11,434 participants were included. IPT for acute-phase depression had moderate-to-large effects compared with control groups (g=0.60; 95% CI=0.45–0.75). No significant difference was found with other therapies (differential g=0.06) and pharmacotherapy (g=–0.13). Combined treatment was more effective than IPT alone (g=0.24). IPT in subthreshold depression significantly prevented the onset of major depression, and maintenance IPT significantly reduced relapse. IPT had significant effects on eating disorders, but the effects are probably slightly smaller than those of cognitive-behavioral therapy (CBT) in the acute phase of treatment. In anxiety disorders, IPT had large effects compared with control groups, and there is no evidence that IPT was less effective than CBT. There was risk of bias as defined by the Cochrane Collaboration in the majority of studies. There was little indication that the presence of bias influenced outcome. Conclusions: IPT is effective in the acute treatment of depression and may be effective in the prevention of new depressive disorders and in preventing relapse. IPT may also be effective in the treatment of eating disorders and anxiety disorders and has shown promising effects in some other mental health disorders.
ASSOCIATION BETWEEN PRE-CATHETERIZATION USE OF P2Y12 INHIBITORS WITH TIMING OF CABG AND CABG-RELATED OUTCOMES IN PATIENTS PRESENTING WITH NSTEMI AND SURGICAL CORONARY DISEASE: INSIGHTS FROM NCDR ®
Authors: Marwan Badri, Amr Abdelbaky, Shuang Li, Karen Chiswell, Tracy Wang
Journal: Journal of the American College of Cardiology (2016)
UTILIZATION OF A SIMPLE HISTORY AND EKG-BASED ALGORITHM TO IMPROVE DIAGNOSTIC ACCURACY OF ST ELEVATIONS FOR ACUTE EPICARDIAL OCCLUSION
Authors: Jason Matos, Benjamin Bier, Ara Tachjian, Ankur Kalra, Fernando Contreras Valdes, Michael Gavin, Duane Pinto
Journal: Journal of the American College of Cardiology (2016)
Childhood Cancer and Cystic Fibrosis
Authors: C. M. ROBERTSON, M. M. HAWKINS
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Childhood Cancer and Cystic Fibrosis Get access C. M. ROBERTSON, C. M. ROBERTSON Search for other works by this author on: Oxford Academic PubMed Google Scholar M. M. HAWKINS M. M. HAWKINS Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 19, 4 October 1995, Pages 1486–1487, https://doi.org/10.1093/jnci/87.19.1486-a Published: 04 October 1995
TCTAP C-107 Successful Retrograde Coronary Angioplasty of Left Circumflex Ostial Chronic Total Occlusion by Pulling RG3 Guidewire with Gooseneck Wire Because of Stucking at Acute Branching of Circumflex from Left Main Trunk
Authors: Hiroaki Yamamoto, Chieko Itamoto, Hideo Miura, Mutsuki Kodaira, Tsunesuke Kohno, Masashi Hattori, Yu Matsumura, Fukitaka Yamaki
Journal: Journal of the American College of Cardiology (2015)
Dermatomyositis Complicated by Generalized Amyloidosis
Authors: Albert H. Gelderman, Robert A. Levine, Kenneth A. Arndt
Journal: New England Journal of Medicine (1962)

THE nature and pathogenesis of amyloidosis remain enigmatic despite a variety of suggested etiologic factors. Among those proposed is an alteration in the chemical composition and physical properties of the connective-tissue ground substance,1 which is also considered to be the basis of many of the connective-tissue disorders.2 Evidence of a causal relation beween the so-called "collagen diseases" and amyloidosis is supported by the frequent association of the latter with rheumatoid arthritis.3 The concurrence of two rare diseases, dermatomyositis and generalized amyloidosis, prompted this report. This association, to our knowledge, has not previously been reported, and suggests the possibility of a . . .
AB0728 Comparison of effects of standard- and low-dose etanercept on inflammatory synovitis in rheumatoid arthritis patients as assessed by ultrasonography
Authors: K. Mamoto, T. Koike, T. Okano, Y. Sugioka, M. Tada, K. Inui, H. Nakamura
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> The presence of synovitis has been recognized as one of the most important predictive factors of subsequent structural damage in patients with rheumatoid arthritis (RA). We previously reported that the effects of low-dose etanercept (ETN) (25 mg/week) were not inferior to the effects of standard-dose ETN (50 mg/week) clinically, but in terms of the radiographic non-progression rate, the effects of low-dose ETN were inferior to the effects of standard-dose ETN in the PRECEPT study. It was considered that low-dose ETN may not be able to suppress inflammatory synovitis. The aim of this study was to compare ultrasonographic inflammatory synovitis between patients using standard- and low-dose ETN for RA. <h3>Methods</h3> Patients with RA receiving standard- and low-dose ETN underwent musculoskeletalultrasonography (US) at 34 synovial sites (30 joints) in the following joints: bilateral first to fifth MCP joints (dorsal recess), first IP and second to fifth PIP (dorsal recess) joints, the wrists (dorsal radial, dorsal median, and dorsal ulnar) and second to fifth MTP (dorsal recess) joints. The gray scale (GS) and power Doppler (PD) signals were scored in each joint using a semiquantitative scale from 0 to 3. The GSUS and PDUS scores were compared with the sums of scores obtained for the 34 synovial sites and the maximum score between two groups. <h3>Results</h3> We analyzed 31 and 21 patients who received standard- and low-dose ETN, respectively. The overall comparison showed no significant differences between groups. However, when we analyzed patients in remission and low disease activity, the PDUS score and maximum PD score were significantly higher in the low-dose ETN group. In particular, the PDUS score in wrist were significantly higher in the low-dose ETN group. But, GSUS score showed no significant difference between two groups. (Table 1) <h3>Conclusions</h3> Low-dose ETN is not inferior to standard-dose ETN in terms of effects on clinical assessment. However, in terms of ultrasonographic inflammatory synovitis, the effects of low-dose ETN may be inferior to the effects of standard-dose ETN. We consider that synovitis may not be suppressed sufficiently, and therefore joint destruction may progress, in RA patients receiving low-dose ETN. <h3>Disclosure of Interest</h3> K. Mamoto: None Declared, T. Koike Speakers bureau: akeda Pharmaceutical, Mitsubishi, T. Okano: None Declared, Y. Sugioka: None Declared, M. Tada Grant/research support from: Japan Osteoporosis Foundation grant 2013, K. Inui: None Declared, H. Nakamura: None Declared
FACTORS ASSOCIATED WITH STATIN RE-INITIATION IN MEDICARE BENEFICIARIES: A CASE-CROSSOVER STUDY
Authors: John N. Booth, Lisandro Colantonio, Robert Rosenson, Ligong Chen, Monika Safford, Meredith Kilgore, Todd Brown, Emily Levitan, Benjamin Taylor, Ricardo Dent, Keri Monda, Paul Muntner
Journal: Journal of the American College of Cardiology (2016)
OC-028 Developing sustainable GI endoscopy training in Malawi
Authors: J Geraghty, A Kankwatira, M Feeney, M Hendrickse, L Kalongolera, R Malamba, N Mtunthama, H Mwandumba, P O'Toole, M Gordon
Journal: Gut (2012)

<h3>Introduction</h3> Sustainable endoscopy services could improve management of upper gastrointestinal malignancy and haemorrhage, both common in Malawi. Since 2008 we have committed to improving endoscopy training through an International Health Link (IHL) partnership with Malawi. We aimed to (1) develop a sustainable training "hub" with locally-trained Trainers in Blantyre (2) develop locally-relevant training courses, (3) extend training support to regional hospital "spokes". <h3>Methods</h3> We partnered in five training visits to Malawi, funded by the Tropical Health Education Trust and the British Society of Gastroenterology. We ran 14 courses (Basic Skills, Skills Enhancement, Training the Gastroscopy Trainers (TGT) and Endoscopy Nurses) involving 52 delegate-training-episodes (29 local doctors, 12 clinical officers (COs), three expatriate doctors, eight nurses). Outcomes were monitored by JAG-format DOPS and course evaluations. Progress over time towards the three aims was assessed. <h3>Results</h3> Aim 1) Training models and audit, reporting and assessment tools were introduced in Blantyre. The mean number of delegate-episodes increased from 6.3 during the first four visits, to 20 during the last two visits. During the first four visits the local faculty was four expatriate doctors and one CO, increasing to seven local doctors, five COs, two nurses and one expatriate doctor during the last two visits. In the first four visits, 16/21 delegate-episodes involved only skills learning and 5/21 (24%) were as mentored or local faculty, while in the last two visits, 25/40 involved only skills learning and 15/40 (38%) were as mentored or local faculty. In 2011 we ran and evaluated the first TGT within Malawi. Aim 2) We developed a Basic Skills in Gastroscopy course appropriate to local circumstances, which was delivered, evaluated and modified over each visit, and ultimately delivered by two locally-trained Trainers. Aim 3) The delegates9 region of origin for the first four visits was 18/19 from Blantyre, and for the last two visits was 15/40 Blantyre, 13/40 Lilongwe, 7/40 Zomba, 3/40 Mzuzu and 2/40 Zambia. The origin of UK external faculty increased from 1 to 3 sites, and two new IHLs were established with Lilongwe and Zomba. <h3>Conclusion</h3> IHL partnerships represent a sustainable means of improving GI endoscopy training. Modified JAG-format courses, assessments and evaluations were useful even in a resource-limited setting. A hub-and-spoke model helped to support other regions. Future training priorities include training in therapy and further development of local trainers. Local reporting tools should allow audit of outcomes across regions. <h3>Competing interests</h3> None declared.
Expression of fatty acid synthase as a prognostic marker in triple negative breast cancer.
Authors: S Kang, Y Jeon, S Lee, Y Bae
Journal: Cancer Research (2009)

Abstract Abstract #1082 Background: Fatty acid synthase (FAS), the key enzyme required for fatty acid biosynthesis, is minimally expressed in most normal human tissue. Recent studies have demonstrated that hyperactivity or overexpression of FAS is a common feature in subset of sex steroid-related tumors, including breast carcinoma. Moreover, up-regulation of FAS gene expression is more pronounced in more advanced tumors, and strong expression of FAS seems to be associated with a poor prognosis of breast cancer. We examined the expression of FAS in invasive breast carcinomas to investigate the prognostic value of FAS expression in a large cohort of breast carcinomas with long term follow up data.&amp;#x2028; Methods: Five hundred and ninety six cases of invasive breast carcinoma, retrospectively selected from 1987-2004, were incorporated into tissue microarrays (TMAs). We performed immunohistochemical stains for FAS, ER, progesterone receptor (PR) and Her-2/neu. Triple-negative breast cancers (TNBCs) were defined as those with ER-, PR- and Her-2/neu-negative results. The results of immunohistochemical stains were correlated with other known clinicopathologic parameters and evaluated for an effect on estimating prognosis.&amp;#x2028; Results: The mean age at diagnosis was 47.2 (ranges 20∼85 years) with a mean tumor size of 2.5cm (ranges 0.4∼11cm). The expression of FAS was positive in 437 (73.3%) cases. There was no significant correlation between the expression of FAS and clinicopathologic characteristics of the tumor (age, tumor size, lymph node metastasis and lymphovascular invasion) (p&amp;gt;0.05). FAS expression was inversely correlated with histologic grade (p=0.009) and positively correlated with the expression of ER (p&amp;lt;0.001), PR (p&amp;lt;0.001) and Her-2/neu (p&amp;lt;0.001). One hundred thirty eight of 596 cases (23.1%) were TNBCs. FAS-expressing breast invasive carcinomas had a higher tendency to have triple-negative phenotype when compared to FAS-negative cancers (p&amp;lt;0.001) with a mean follow up of 72.3 months, there was no significant survival difference according to the FAS expression (p&amp;gt;0.05). However, FAS-positive group showed shorter disease free survival (DFS) (p=0.014) and overall survival (OS) (p=0.021) than FAS-negative group in patients with TNBC.&amp;#x2028; Conclusion: This study showed that FAS expression is strongly associated with the expression of hormonal receptors and Her-2/neu in invasive breast carcinomas. Especially FAS could be a potential prognostic marker in TNBCs. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1082.
O5.09 * VENTRICULAR HIGH GRADE GLIOMA: NEUROENDOSCOPY AND ADJUVANT THERAPY
Authors: P. A. Oppido, F. Cattani, C. M. Carapella, V. Villani
Journal: Neuro-Oncology (2014)

INTRODUCTION: In ventricular high grade glioma the obstructive hydrocephalus and the subsequent neurological worsening are usually the limit for chemotherapy and radiotherapy. Recently, in ventricular tumours causing obstructive hydrocephalus neuroendoscopy has gained even more appeal as a first choice procedure since it is possible to simultaneously perform tumour biopsy and endoscopic third ventriculostomy (ETV) or septostomy. The immediate relief of intracranial hypertension and the availability of specimens for a pathological diagnosis allow time for planning the most suitable treatment strategy based on histological diagnosis and CSF tumour markers. METHODS: Since 2001 in 35 patients affected by hydrocephalus due to a ventricular tumour the neuroendoscopic biopsy was performed. In 15 patients ( age 17 - 79 yrs) the NMR showed hydrocephalus due to an infiltrating tumour with contrast enhancement: in 7 inside the third ventricle, in 8 inside the lateral ventricle. In all patients the clinical signs of progressive intracranial hypertension at admission were present. After neuroendoscopy and histological diagnosis radiotherapy and/or chemotherapy were performed. RESULTS: In 14 patients the biopsy was performed, while in one case of occipital corn tumour was abandoned. In 9 cases tumour biopsy the Tu laser for bleeding control and tumour ablation was used. The histology was: in 10 GBM, in 1 malignant PNET, in 1 malignant xanthoastrcytoma, in 1 anaplastic ependymoma, 1 metastasis. During the same neuroendoscopic procedure in 7 cases the third ventricolostomy (ETV) and in 4 the septostomy were realized. In 12 patients the clinical outcome improved and radiotherapy and chemotherapy were possible. The median overall survival was 4 months (2 - 12) for progression disease. CONCLUSION: Based on our experience, the neuroendoscopic biopsy should be considered in the diagnosis and therapy of ventricular tumours, allowing subsequent tumor therapy. Furthermore, CSF pathways can be restored by ETV or septostomy to control intracranial hypertension. By improving the clinical outcome radiotherapy and /or chemotherapy in high grade glioma is possible.
OC-035 Lifetouch®: A Novel Remote Monitoring Device To Identify Patients With Advanced Cirrhosis Most At Risk Of Decompensation – A Proof Of Concept Study
Authors: D Chatterjee, HE Jones, AG León, G Privitera, R Jalan, RP Mookerjee
Journal: Gut (2014)

<h3>Introduction</h3> Hospital readmission from inter-current illness is common in advanced cirrhosis. Community monitoring of these patients with simple information-based technology may facilitate early problem recognition and intervention. Heart rate variability (HRV) has been deemed the ‘gold standard’ tool to characterise autonomic dysfunction, which is widely reported in cirrhosis, and remains independent of aetiology, and its severity has been shown to correlate with prognosis. However, the methods to study continuous measurement of HRV and studies in advanced cirrhosis are limited. <h3>Aims</h3> This study used a wireless-monitoring technology, Lifetouch® system (Isansys), to assess changes of HRV remotely in acute-on-chronic liver failure (ACLF) patients, and evaluated the relationship to the severity of disease and inflammatory indices. <h3>Methods</h3> Following ethical and local site approval, nineteen patients (13 male/6 female; mean age 52.5 ± 12.0 years) had HRV assessment following presentation to The Royal Free hospital, using the Lifetouch<sup>®</sup> system, with the standard deviation of the R-R interval (SDNN) used to collect changes in HRV. This novel system enabled continuous, wireless evaluation of HRV, which was compared with clinical, biochemical and inflammatory indices (IL-6, IL-8 and IL-10 measured by multiplex cytokine analysis). <h3>Results</h3> HRV, as determined by SDNN, was significantly greater in cirrhosis patients with Child-Pugh scores &lt;10 compared to &gt;10 (31.26 ± 14.90 vs. 10.80 ± 5.61 ms). Similarly, UKELD correlated inversely with SDNN (R<sup>2 </sup>= -0.46; p &lt; 0.01). Spearman’s rank analysis of SDNN in relation to the inflammatory indices: WCC, CRP, IL-6, IL-8 and IL-10 levels were -0.60 (p = 0.01), -0.56 (p = 0.01), -0.77 (p = 0.02), -0.86 (p = 0.01) and -0.79 (p = 0.04), respectively. Using a SDNN cut-off of ≤20 ms to signify patients with advanced disease (Child C), all inflammatory indices were shown to be significantly increased (P &lt; 0.01). <h3>Conclusion</h3> This pilot study provides proof of concept that remote monitoring showing reduced HRV, identifies patients with increased inflammation, more advanced liver disease and those most likely to present with acute decompensation of cirrhosis. Further study and refinement of this system may facilitate community monitoring of advanced liver disease patients, to provide ‘alarm’ signals that highlight acute decompensation and precipitate early intervention care pathways. <h3>Disclosure of Interest</h3> None Declared.
P65 Is serum N-terminal pro B type natriuretic peptide (NT-proBNP) measurement useful in the investigation of unilateral pleural effusions?--a prospective observational study
Authors: C. E. Hooper, I. Rider, R. S. Finn, A. J. Morley, J. E. Harvey, A. Skyrme-Jones, N. A. Maskell
Journal: Thorax (2010)

Measurement of serum NT-proBNP has been proposed in the investigation of pleural effusions, particularly in the diagnosis of cardiac failure in those misclassified as exudates by Light9s criteria. Studies have reported excellent diagnostic accuracy for the test but have included both bilateral and unilateral effusions and applied short follow-up periods. We prospectively examined the diagnostic utility of serum NT-proBNP in a consecutive series of unilateral pleural effusions with robust follow-up and diagnostic criteria. <h3>Method</h3> Consecutive patients presenting to a UK teaching hospital with an undiagnosed unilateral pleural effusion underwent clinical assessment including CXR, ECG, echocardiogram, thoracentesis (and CT when appropriate). Light9s criteria were applied. Serum NT-proBNP was measured using point of care ELISA. Patients were followed up to histological/microbiological diagnosis, radiographic resolution or 12 months. Echocardiograms were double reported and diagnosis determined independently by two respiratory consultants—all blind to NT-proBNP results. <h3>Results</h3> 118 patients. Median age 74 (42–95). 39 in patients, 79 outpatients. 18 transudates, 92 exudates. 30 large, 66 moderate, 22 small. Diagnoses: primary cardiac cause (PCC) 20/118, Malignant 57/118, PE 4/118, Non-cardiac transudate 3/118, other benign cause 30/118. The ROC curve for NT-proBNP discriminating effusions of PCC gave an AUC of 0.845 (0.774–0.934). At cut-off of age and sex adjusted 97.5th centile (healthy population) NT-proBNP had sensitivity 100%, Specificity 53%, PPV 30% and NPV 100% and all four cardiac exudates were correctly diagnosed. At an optimum cut-off of 1500 pg/ml—sensitivity 75%, specificity 76%, PPV 38% and NPV 94%. Co-morbid cardiac disease was common in patients without a PCC for effusion with 70% having significant abnormalities on echocardiogram but cardiac disease was considered to be contributing to effusion in only 9/98 of this group. <h3>Conclusion</h3> The excellent negative predictive value of NT-proBNP, particularly at an age and sex adjusted cut-off level gives the test utility to rule out a primarily cardiac cause in selected cases of unilateral pleural effusion. Co-morbid cardiac disease and associated NT-proBNP elevation is very common in patients with a non-cardiac origin of pleural effusion such that a positive test at baseline should not alter the initial investigation pathway, particularly amongst pleural exudates.
Abstract 4752: Induction of cytotoxic T lymphocytes primed with tumor RNA-loaded dendritic cells in esophageal squamous cell carcinoma: Preliminary step for DC vaccine design
Authors: Omeed Moaven, Mehran Gholamin, Moein Farshchian, Mahmoud Mahmoudi, Mojtaba Sankian, Bahram Memar, Mohammad N. Forghani, Reza Malekzadeh, Mohammad R. Abbaszadegan
Journal: Cancer Research (2010)

Abstract Backgrounds: Dendritic Cells (DC) are potent antigen presenting cells with the ability to prime naïve T cells and convert them to cytotoxic CTL. We evaluated the capability of autologous DCs transfected with total Tumor and normal RNA to induce cytotoxic CTL as the preliminary step to design DC-based vaccine in the esophageal squamous cell carcinoma (ESCC). Methods: Monocytes-derived DCs were electroporated with either total tumor RNA or normal RNA. T cells were then primed with tumor RNA transfected DCs and lysing effects of the generated CTL were measured with Cytotoxicity assay and IFN-γ Release Elispot Assay. Results: Cytotoxicity against DCs loaded with tumoral RNA was induced (%24.8±5.2 SEM) while in normal RNA-loaded DCs it was minimal (%6.1±2.4 SEM) and significantly lower (p &amp;lt; 0.05). INF-γ secretion was more than 2-folds higher in tumoral RNA-loaded DCs when compared with normal RNA-loaded DCs (p &amp;lt; 0.05). Conclusion: Electroporating DCs with tumor RNA made tumor antigen presenting cells that enhanced cytotoxicity effects of T cells against ESCC. This may be a useful autologous ex vivo screening tool for confirming the lytic effects of primed T cells on tumor and evaluate probable further adverse effects on noncancerous tissue. These data are a crucial preliminary step to establish a total tumor RNA-pulsed DC vaccine therapy of ESCC. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4752.