tbuckley/cabot-search huggingface dataset:
The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study
Authors: Maria Grau-Pérez, Chin-Chi Kuo, Miranda Spratlen, Kristina A. Thayer, Michelle A. Mendez, Richard F. Hamman, Dana Dabelea, John L. Adgate, William C. Knowler, Ronny A. Bell, Frederick W. Miller, Angela D. Liese, Chongben Zhang, Christelle Douillet, Zuzana Drobná, Elizabeth J. Mayer-Davis, Miroslav Styblo, Ana Navas-Acien
Journal: Diabetes Care (2016)

OBJECTIVE Little is known about arsenic and diabetes in youth. We examined the association of arsenic with type 1 and type 2 diabetes in the SEARCH for Diabetes in Youth Case-Control (SEARCH-CC) study. Because one-carbon metabolism can influence arsenic metabolism, we also evaluated the potential interaction of folate and vitamin B12 with arsenic metabolism on the odds of diabetes. RESEARCH DESIGN AND METHODS Six hundred eighty-eight participants &amp;lt;22 years of age (429 with type 1 diabetes, 85 with type 2 diabetes, and 174 control participants) were evaluated. Arsenic species (inorganic arsenic [iAs], monomethylated arsenic [MMA], dimethylated arsenic [DMA]), and one-carbon metabolism biomarkers (folate and vitamin B12) were measured in plasma. We used the sum of iAs, MMA, and DMA (∑As) and the individual species as biomarkers of arsenic concentrations and the relative proportions of the species over their sum (iAs%, MMA%, DMA%) as biomarkers of arsenic metabolism. RESULTS Median ∑As, iAs%, MMA%, and DMA% were 83.1 ng/L, 63.4%, 10.3%, and 25.2%, respectively. ∑As was not associated with either type of diabetes. The fully adjusted odds ratios (95% CI), rescaled to compare a difference in levels corresponding to the interquartile range of iAs%, MMA%, and DMA%, were 0.68 (0.50–0.91), 1.33 (1.02–1.74), and 1.28 (1.01–1.63), respectively, for type 1 diabetes and 0.82 (0.48–1.39), 1.09 (0.65–1.82), and 1.17 (0.77–1.77), respectively, for type 2 diabetes. In interaction analysis, the odds ratio of type 1 diabetes by MMA% was 1.80 (1.25–2.58) and 0.98 (0.70–1.38) for participants with plasma folate levels above and below the median (P for interaction = 0.02), respectively. CONCLUSIONS Low iAs% versus high MMA% and DMA% was associated with a higher odds of type 1 diabetes, with a potential interaction by folate levels. These data support further research on the role of arsenic metabolism in type 1 diabetes, including the interplay with one-carbon metabolism biomarkers.
B Cell Receptor (BCR) Ligation Enhances Cell Survival in Progressive Chronic Lymphocytic Leukemia (CLL).
Authors: Pierre-Antoine Deglesne, Natalie Chevallier, Remi Letestu, Celia Salanoubat, Laurence Sanhes, Joelle Nataf, Nadine Varin-Blank, Florence Ajchenbaum-Cymbalista
Journal: Blood (2004)
Glucose Hypermetabolism in Contralateral Basal Ganglia Demonstrated by Serial FDG PET/CT Scans in a Patient With SLE Chorea
Authors: Na Niu, Ruixue Cui
Journal: Clinical Nuclear Medicine (2016)

We reported a 24-year-old woman who developed a movement disorder of mouth and limbs during systemic lupus erythematosus. Brain MRI did not find any abnormalities. Increased FDG uptake in basal ganglia was found using FDG PET/CT brain scan. The symptoms remitted after therapy and the activities of the original hypermetabolic regions were down to normal in the follow-up FDG PET/CT scan. This case implies that the pathophysiology of chorea in systemic lupus erythematosus is different from that of chorea in other diseases, such as Huntington disease and chorea-acanthocytosis, in which hypometabolic basal ganglia was found.
Pharmacokinetics of a Recombinant Von Willebrand Factor in Patients with Severe Von Willebrand Disease
Authors: Margaret V Ragni, Giancarlo Castaman, Joan Cox Gill, Peter Kouides, Miranda Chapman, Arthur Sytkowski, Ortrun Obermann-Slupetzky, Isabella Presch, Sandor Fritsch, Bruce M. Ewenstein
Journal: Blood (2015)
Regulatory Mrna/Microrna Networks in CD34+ Cells From Primary Myelofibrosis.
Authors: Ruggiero Norfo, Roberta Zini, Valentina Pennucci, Elisa Bianchi, Simona Salati, Paola Guglielmelli, Andrea Bisognin, Vittorio Rosti, Daniela Pietra, Clara Ricci, Tiziana Fanelli, Silvia Salmoiraghi, Giorgia Sacchi, Samantha Ruberti, Giovanni Barosi, Mario Cazzola, Stefania Bortoluzzi, Sergio Ferrari, Enrico Tagliafico, Alessandro M. Vannucchi, Rossella Manfredini
Journal: Blood (2012)
84P Predictive factors for non-sentinel lymph node involvement in patients with breast cancer and 1-2 positive sentinel lymph nodes treated with breast conservation
Authors: Y. Tanaka, T. Fujita, Y. Sagara, S. Nishida, S. Shiba, C. Miyazaki, H. Joutoku, M. Sakuragi, A.K. Lefor, Y. Hozumi, N. Sata
Journal: Annals of Oncology (2015)
Unravelling the multiple roles of apolipoprotein E in the hepatitis C virus life cycle
Authors: Philippe Roingeard, Julie Dreneau, Jean-Christophe Meunier
Journal: Gut (2016)

Worldwide, about 3% of the population is infected with HCV, and chronic infection is associated with a risk of serious progressive liver disease. The recent introduction of direct-acting antiviral agents (DAAs) has considerably improved the treatment of chronic HCV infection, and most patients are now cured without major side effects.1 However, subgroups of patients difficult-to-treat and requiring additional therapeutic approaches will probably emerge. Furthermore, DAAs are very expensive, limiting their use in some countries.1 Thus, in the absence of prophylactic vaccines, improvements to our understanding of the mechanisms underlying virus assembly, maturation and secretion from the cell are required, to facilitate the development of new treatment options.

In patients, HCV particles circulate as hybrid particles, known as lipoviroparticles (LVPs), combining components of both HCV and very low-density lipoprotein (VLDL).2 LVPs have a low density (<1.06 g/mL) and are highly infectious. Their maturation and release are tightly associated with VLDL synthesis, leading to cholesterol and triglyceride export from hepatocytes. Similar characteristics have been described for viruses produced in cell culture (HCVcc) by human Huh7.5 hepatoma cells.2

LVPs are rich in triacylglycerol and total cholesterol. They contain the viral RNA, capsid protein, envelope glycoproteins and apolipoproteins. They carry highly variable amounts of lipids and are therefore highly heterogeneous in size and density. LVPs have been shown to associate with apolipoprotein B and apolipoprotein E (ApoE).3 ApoE is a soluble and exchangeable apolipoprotein. It plays a critical role in VLDL assembly and is also involved in cellular lipid transport.2

The importance of ApoE for the life cycle of HCV has been confirmed by studies showing ApoE to be required for LVP production4 ,5 HCV infectivity being associated with the presence of ApoE in …
OCT-1 Activity in CML CD34+ Cells Is Not Predictive of Molecular Response to Imatinib Treatment in CP-CML Patients, Despite the Strong Predictive Value of MNC OCT-1 Activity.
Authors: Jane R Engler, Amity Frede, Verity A Saunders, Andrew Christopher William Zannettino, Deborah L White, Timothy P. Hughes
Journal: Blood (2009)
Hepatitis C virus and lymphoma
Authors: Antonio Ponzetto, Guido Carloni
Journal: Hepatology (2016)

These subgroups could represent those in need of frequent examinations to exclude lymphoid neoplasias. Antonio Ponzetto, M.D.1 Guido Carloni, M.D.2 1Department of Internal Medicine University of Turin Turin, Italy 2Istituto Farmacologia Traslazionale Consiglio Nazionale delle Ricerche Rome, Italy
Preparticipation cardiovascular screening: clinical partnership is the only certainty
Authors: Aaron L Baggish, Richard J Kovacs
Journal: British Journal of Sports Medicine (2016)

Sports cardiology is a rapidly evolving medical subspecialty with an overarching aim of providing comprehensive clinical cardiovascular care for competitive athletes and highly active patients. In Europe, the USA and beyond, a growing number of cardiologists are dedicating themselves to the acquisition of the specific skills required to optimally care for this unique population. At the most fundamental level, effective sports cardiology requires partnership with other members of the athlete care team including team physicians, sports medicine specialist, athletic trainers and coaches. In no setting is the importance of these partnerships more critical, than in the arena of preparticipation cardiovascular screening (PPCS). For several decades, professional governance bodies charged with overseeing the cardiovascular care of athletes have universally recommended PPCS based on the notion that detection and subsequent management of occult cardiovascular diseases has the potential to reduce the incidence of sudden death during athletic participation.1 ,2 Despite near universal endorsement by cardiovascular and sports medicine organisations, PPCS remains shrouded in controversy. Key unresolved issues including the …
Matched Cohort Analysis of Allogeneic Hematopoietic Cell Transplantation (HCT) with Total Marrow Irradiation/Fludarabine/Melphalan (TFM) Versus Fludarabine/Melphalan (FM) Conditioning for Acute Leukemia
Authors: Joseph Rosenthal, Jefrrey Wong, Anthony Selwyn Stein, Tracy Stiller, Joycelynne Palmer, Stephen J. Forman
Journal: Blood (2012)
Predictive Value of Cytogenetics on Outcomes of Stem Cell Transplantation in Acute Myeloid Leukemia.
Authors: Jinny Park, Mark H. Lee, Se-Hoon Lee, Joon Oh Park, Kihyun Kim, Chul W. Jung, Won Seok Kim, Young Suk Park, Young-Hyuck Im, Won Ki Kang, Keunchil Park
Journal: Blood (2004)
WP1130 Inhibits Signaling through BCR-ABL Ubiquitination and Cytoplasmic to Aggresome Trafficking to Induce Apoptosis of CML Cells.
Authors: Nicholas J Donato, Hanshi Sun, Vaibhav Kapuria, Luke F Peterson, Geoffrey Bartholomeusz, William G. Bornmann, Moshe Talpaz
Journal: Blood (2009)
Should Chemotherapy Be Used in Nonmetastatic Prostate Cancer?
Authors: Julie N. Graff, Joshi J. Alumkal, Tomasz M. Beer
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Donor Lymphocyte Infusions (DLI) Following Haplo Bone Marrow Transplantation (hBMT) with High-Dose of Cyclophosphamide Post-Transplant As Gvhd Prophylaxis
Authors: Anna Ghiso, Annamaria Raiola, Francesca Gualandi, Alida Dominietto, Riccardo Varaldo, Maria Teresa van Lint, Stefania Bregante, Carmen Di Grazia, Teresa Lamparelli, Silvia Luchetti, Simona Geroldi, Elisabetta Tedone, Andrea P Bacigalupo
Journal: Blood (2012)
Progressive and Biased Divergent Evolution Underpins the Origin and Diversification of Peridinin Dinoflagellate Plastids
Authors: Richard G. Dorrell, Christen M. Klinger, Robert J. Newby, Erin R. Butterfield, Elisabeth Richardson, Joel B. Dacks, Christopher J. Howe, Ellen R. Nisbet, Chris Bowler
Journal: Molecular Biology and Evolution (2016)

Dinoflagellates are algae of tremendous importance to ecosystems and to public health. The cell biology and genome organization of dinoflagellate species is highly unusual. For example, the plastid genomes of peridinin-containing dinoflagellates encode only a minimal number of genes arranged on small elements termed "minicircles". Previous studies of peridinin plastid genes have found evidence for divergent sequence evolution, including extensive substitutions, novel insertions and deletions, and use of alternative translation initiation codons. Understanding the extent of this divergent evolution has been hampered by the lack of characterized peridinin plastid sequences. We have identified over 300 previously unannotated peridinin plastid mRNAs from published transcriptome projects, vastly increasing the number of sequences available. Using these data, we have produced a well-resolved phylogeny of peridinin plastid lineages, which uncovers several novel relationships within the dinoflagellates. This enables us to define changes to plastid sequences that occurred early in dinoflagellate evolution, and that have contributed to the subsequent diversification of individual dinoflagellate clades. We find that the origin of the peridinin dinoflagellates was specifically accompanied by elevations both in the overall number of substitutions that occurred on plastid sequences, and in the Ka/Ks ratio associated with plastid sequences, consistent with changes in selective pressure. These substitutions, alongside other changes, have accumulated progressively in individual peridinin plastid lineages. Throughout our entire dataset, we identify a persistent bias toward non-synonymous substitutions occurring on sequences encoding photosystem I subunits and stromal regions of peridinin plastid proteins, which may have underpinned the evolution of this unusual organelle.
Thalidomide (thal), Lenalidomide (len), and Dexamethasone (dex)-Associated Venous Thromboembolism (VTE) and Reported VTE Rates Pre- and Post-FDA Approval: Optimal Prophylaxis Strategies Are Still Unclear
Authors: Monica Boen, June McKoy, Dennis West, Beatrice Edwards, Jayesh Mehta, Seema Singhal, Charles L. Bennett
Journal: Blood (2008)
Scenarios for the future of mental health care: a social perspective
Authors: Domenico Giacco, Michaela Amering, Victoria Bird, Thomas Craig, Giuseppe Ducci, Jürgen Gallinat, Steven George Gillard, Tim Greacen, Phil Hadridge, Sonia Johnson, Nikolina Jovanovic, Richard Laugharne, Craig Morgan, Matthijs Muijen, Georg Schomerus, Martin Zinkler, Simon Wessely, Stefan Priebe
Journal: The Lancet Psychiatry (2016)
Clinical Significance of the Tumor Suppressor p53 Codon 72 Polymorphic Variants in Multiple Myeloma.
Authors: Natalia C. Gonzalez-Paz, Wee Joo Chng, Shaji Kumar, Tammy Price-Troska, Scott Van Wier, Gregory Ahmann, Kimberly Henderson, Morie Gertz, Robert Kyle, Philip Greipp, Rafael Fonseca
Journal: Blood (2005)
Influence of Age on Survival after a Tandem Hematopoietic Stem Cell Transplantation Procedure in Patients with Multiple Myeloma: Results of the Prospective GEM-2000 Protocol.
Authors: A. Sureda, J. Blade, J.J. Lahuerta, J. de la Rubia, R. Martinez, D. Carrera, J. Garcia-Laraña, A. Alegre, M. Hernandez, C. Rivas, J.M. Ribera, M.J. Peñarrubia, L. Palomera, F. Prosper, F. de Arriba, A. Leon, E. Abella, B. Hernandez-Ruiz, F. Casado, J.C. Garcia-Ruiz, J. Besalduch, F.J. Fernandez-Calvo, A. Touchard, J. San Miguel
Journal: Blood (2004)
SNP Array Analysis Reveals Copy Number Alterations and Uniparental Disomy in Mantle Cell Lymphomas at High Resolution.
Authors: Elena M. Hartmann, Itziar Salaverria, Silvia Bea, Andreas Zettl, Pedro Jares, Francesc Bosch, German Ott, Hans Konrad Muller-Hermelink, Andreas Rosenwald, Elias Campo
Journal: Blood (2007)
Deferasirox (Exjade®, ICL670) Is Effective and Tolerable in β-Thalassemia Patients with High Iron Burden and History of Inadequate Chelation Therapy.
Authors: A. Taher, A. El-Beshlawy, A. Al Jefri, M. Elalfy, K. Al Zir, S. Daar, G. Damanhouri, U. Krahn, D. Hadler
Journal: Blood (2006)
Transporter occluded-state conformation-induced endocytosis: Amino acid transporter ATB0,+-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy
Authors: Qiuhua Luo, Ping Gong, Mengchi Sun, Longfa Kou, Vadivel Ganapathy, Yongkui Jing, Zhonggui He, Jin Sun
Journal: Journal of Controlled Release (2016)
Reduced CD26 Dipeptidylpeptidase IV Membrane Expression and Activity of CD34+ Cells from Patients with Myelofibrosis with Myeloid Metaplasia.
Authors: Rita Campanelli, Margherita Massa, Vittorio Rosti, Gaetano Bergamaschi, Gianluca Viarengo, Monia Marchetti, Ronald Hoffman, Giovanni Barosi
Journal: Blood (2006)
The Addition of Rituximab to Dose-Adjusted EPOCH with HAART Suspension Is Highly Effective and Tolerable in AIDS-Related Lymphoma (ARL) and Allows the Delivery of Abbreviated Chemotherapy.
Authors: Kieron Dunleavy, Alan Wayne, Richard Little, Nicole Grant, Seth Steinberg, Elaine S. Jaffe, Stefania Pittaluga, Robert Yarchoan, Jorge Carrasquillo, John Janik, Wyndham H. Wilson
Journal: Blood (2005)
Efficacy of Thalidomide in the Treatment of Severe Recurrent Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT): Preliminary Results of an Ongoing Study
Authors: Carlo L Balduini, Francesca Bellistri, Fabio Pagella, Francesco Chu, Elina Matti, Giuseppe Spinozzi, Federica Ornati, Cecilia Canzonieri, Carla Olivieri, Cesare Danesino, Marco Benazzo, Rosangela Invernizzi
Journal: Blood (2012)
Surgical and long-term outcomes following oesophagectomy in oesophageal cancer patients with comorbidity
Authors: Hiroshi Ichikawa, Shin-ichi Kosugi, Tatsuo Kanda, Kazuhito Yajima, Takashi Ishikawa, Takaaki Hanyu, Yusuke Muneoka, Takahiro Otani, Masayuki Nagahashi, Jun Sakata, Takashi Kobayashi, Hitoshi Kameyama, Toshifumi Wakai
Journal: International Journal of Surgery (2016)
Detailed Mapping of the Binding Site within Platelet Glycoprotein Ibα for Leukocyte Integrin Mac-1 (αMβ2).
Authors: Qiang Han, Yuandong Peng, Zhiping Chen, Valentin A. Ustinov, Tatiana P. Ugarova, Edward F. Plow, Daniel I. Simon, José A. López
Journal: Blood (2004)
Auditory verbal hallucinations and continuum models of psychosis: A systematic review of the healthy voice-hearer literature
Authors: David Baumeister, Ottilie Sedgwick, Oliver Howes, Emmanuelle Peters
Journal: Clinical Psychology Review (2016)

Recent decades have seen a surge of research interest in the phenomenon of healthy individuals who experience auditory verbal hallucinations, yet do not exhibit distress or need for care. The aims of the present systematic review are to provide a comprehensive overview of this research and examine how healthy voice-hearers may best be conceptualised in relation to the diagnostic versus ‘quasi-‘ and ‘fully-dimensional’ continuum models of psychosis. A systematic literature search was conducted, resulting in a total of 398 article titles and abstracts that were scrutinised for appropriateness to the present objective. Seventy articles were identified for full-text analysis, of which 36 met criteria for inclusion. Subjective perceptual experience of voices, such as loudness or location (i.e., inside/outside head), is similar in clinical and non-clinical groups, although clinical voice-hearers have more frequent voices, more negative voice content, and an older age of onset. Groups differ significantly in beliefs about voices, control over voices, voice-related distress, and affective difficulties. Cognitive biases, reduced global functioning, and psychiatric symptoms such as delusions, appear more prevalent in healthy voice-hearers than in healthy controls, yet less than in clinical samples. Transition to mental health difficulties is increased in HVHs, yet only occurs in a minority and is predicted by previous mood problems and voice distress. Whilst healthy voice-hearers show similar brain activity during hallucinatory experiences to clinical voice-hearers, other neuroimaging measures, such as mismatch negativity, have been inconclusive. Risk factors such as familial and childhood trauma appear similar between clinical and non-clinical voice-hearers. Overall the results of the present systematic review support a continuum view rather than a diagnostic model, but cannot distinguish between ‘quasi’ and ‘fully’ dimensional models. Healthy voice-hearers may be a key resource in informing transdiagnostic approaches to research of auditory hallucinations.
Facing the Rising Tide of Multidrug Resistant Gram-Negative Pathogens in Allogeneic HSCT with Nanosphere's Verigene® System
Authors: Raffaella Greco, Maria Chiara Barbanti, Nicasio Mancini, Laura Infurnari, Renée Pasciuta, Alessandra Forcina, Luca Vago, Fabio Giglio, Carlo Messina, Mara Morelli, Tommaso Perini, Stefania Girlanda, Matteo G Carrabba, Maria Teresa Lupo Stanghellini, Sarah Marktel, Andrea Assanelli, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Massimo Clementi, Fabio Ciceri
Journal: Blood (2015)
Coexistence of OSA may compensate for sleep related reduction in neural respiratory drive in patients with COPD
Authors: Bai-Ting He, Gan Lu, Si-Chang Xiao, Rui Chen, Joerg Steier, John Moxham, Michael I Polkey, Yuan-Ming Luo
Journal: Thorax (2016)

<h3>Background</h3> The mechanisms underlying sleep-related hypoventilation in patients with coexisting COPD and obstructive sleep apnoea (OSA), an overlap syndrome, are incompletely understood. We compared neural respiratory drive expressed as diaphragm electromyogram (EMG<sub>di</sub>) and ventilation during stage 2 sleep in patients with COPD alone and patients with overlap syndrome. <h3>Methods</h3> EMG<sub>di</sub> and airflow were recorded during full polysomnography in 14 healthy subjects, 14 patients with OSA and 39 consecutive patients with COPD. The ratio of tidal volume to EMG<sub>di</sub> was measured to indirectly assess upper airway resistance. <h3>Results</h3> Thirty-five patients with COPD, 12 healthy subjects and 14 patients with OSA completed the study. Of 35 patients with COPD, 19 had COPD alone (FEV<sub>1</sub> 38.5%±16.3%) whereas 16 had an overlap syndrome (FEV<sub>1</sub> 47.5±16.2%, AHI 20.5±14.1 events/hour). Ventilation (V<sub>E</sub>) was lower during stage 2 sleep than wakefulness in both patients with COPD alone (8.6±2.0 to 6.5±1.5 L/min, p&lt;0.001) and those with overlap syndrome (8.3±2.0 to 6.1±1.8 L/min). Neural respiratory drive from wakefulness to sleep decreased significantly for patients with COPD alone (29.5±13.3% to 23.0±8.9% of maximal, p&lt;0.01) but it changed little in those with overlap syndrome. The ratio of tidal volume to EMG<sub>di</sub> was unchanged from wakefulness to sleep in patients with COPD alone and healthy subjects but was significantly reduced in patients with OSA or overlap syndrome (p&lt;0.05). <h3>Conclusions</h3> Stage 2 sleep-related hypoventilation in COPD alone is due to reduction of neural respiratory drive, but in overlap syndrome it is due to increased upper airway resistance.