tbuckley/cabot-search huggingface dataset:
Case 9-1964
Authors: Robert S. Pinals, Wallace H. Clark
Journal: New England Journal of Medicine (1964)

Presentation of CaseA thirty-three-year-old construction worker entered the hospital because of hemoptysis.He had been in excellent health until three weeks previously, when a sore throat occurred, followed by pain in the left shoulder. During the next two and a half weeks pain and swelling developed in a symmetrical fashion in the feet, ankles, knees, shoulders and metacarpophalangeal and proximal interphalangeal joints. Phenylbutazone (Butazolidin) and propoxyphene hydrochloride (Darvon) were prescribed for relief of pain, and he stated that cortisone was injected into the right knee joint. Four days before entry a rash appeared on the feet and the dorsum . . .
Le paludisme dans la région Europe de l'OMS (1971-1999)
Authors: G Sabatinelli, M Ejov, P Joergensen
Journal: Eurosurveillance (2001)

Entre 1996 et 1999, les cas endemiques autochtones declares de paludisme ont diminue de 90 506 a 37 170 dans la region Europe de l’OMS. Cependant, les cas importes ont ete multiplies par huit depuis les annees 1970 : 1 500 cas ont ete declares en 1972, 13 000 en 1999. La France, l’Allemagne, l’Italie et le Royaume-Uni sont les pays les plus touches en Europe occidentale.
P1258 : Prevalence of significant hepatic fibrosis and cirrhosis assessed by the NAFLD fibrosis score in patients attending the diabetic clinic
Authors: J.L. Chin, G. Chan, P.S.-P. Sin, Z. Siddiqui, E. O’Rathallaigh, A. Rahman Aftab, G. Courtney, C. McGurk
Journal: Journal of Hepatology (2015)
Case 24-1963
Authors: Samuel L. Katz, Wallace H. Clark
Journal: New England Journal of Medicine (1963)

Presentation of CaseA thirty-one-year-old mother of two children was admitted to the hospital because of dyspnea and cyanosis.Five days before entry a rash developed over the trunk, associated with symptoms of an upper respiratory infection, and during the next day the rash covered the entire body and face in successive stages. She had moderately severe low-back pain, which was aggravated by walking and voiding and partially relieved by bed rest. Two days before entry there was the onset of a severe cough that was productive of pink, frothy sputum and associated with deep chest pain; tetracycline was given. . . .
Metastatic peritoneal seeding patterns demonstrated by FDG positron emission tomographic imaging.
Authors: EUGENE LIN, JAMES LEAR, ROBERT QUAIFE
Journal: Clinical Nuclear Medicine (2001)

From the Division of Nuclear Medicine, University of Colorado Health Sciences Center, Denver, Colorado Received for publication May 17, 2000. Accepted July 10, 2000. Reprint requests: Eugene C. Lin, Department of Radiology, University Hospital, Box A-034, 4200 East Ninth Avenue, Denver, Colorado 80262. E-mail: [email protected]
Baton-Crc: a Phase 2 Randomized Trial Comparing Tivozanib (Tivo) + Mfolfox6 with Bevacizumab (Bev) + Mfolfox6 in Stage Iv Metastatic Colorectal Cancer (Mcrc)
Authors: A. Benson, J.A. Bridgewater, I. Kiss, F. Eskens, J. Chen, C. Sasse, S. Vossen, C. van Sant, H. Ball, A. Keating, A. Krisvoshik
Journal: Annals of Oncology (2014)
Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents
Authors: Thomas M. Lancaster, David E. Linden, Katherine E. Tansey, Tobias Banaschewski, Arun L. W. Bokde, Uli Bromberg, Christian Büchel, Anna Cattrell, Patricia J. Conrod, Herta Flor, Vincent Frouin, Jürgen Gallinat, Hugh Garavan, Penny Gowland, Andreas Heinz, Bernd Ittermann, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Herve Lemaitre, Frauke Nees, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Michael N. Smolka, Nora C. Vetter, Sarah Jurk, Eva Mennigen, Henrik Walter, Robert Whelan, Gunter Schumann
Journal: JAMA Psychiatry (2016)

Psychotic disorders are characterized by attenuated activity in the brain's valuation system in key reward processing areas, such as the ventral striatum (VS), as measured with functional magnetic resonance imaging.To examine whether common risk variants for psychosis are associated with individual variation in the VS.A cross-sectional study of a large cohort of adolescents from the IMAGEN study (a European multicenter study of reinforcement sensitivity in adolescents) was performed from March 1, 2008, through December 31, 2011. Data analysis was conducted from October 1, 2015, to January 9, 2016. Polygenic risk profile scores (RPSs) for psychosis were generated for 1841 healthy adolescents. Sample size and characteristics varied across regression analyses, depending on mutual information available (N = 1524-1836).Reward-related brain function was assessed with blood oxygen level dependency (BOLD) in the VS using the monetary incentive delay (MID) task, distinguishing reward anticipation and receipt. Behavioral impulsivity, IQ, MID task performance, and VS BOLD were regressed against psychosis RPS at 4 progressive P thresholds (P < .01, P < .05, P < .10, and P < .50 for RPS models 1-4, respectively).In a sample of 1841 healthy adolescents (mean age, 14.5 years; 906 boys and 935 girls), we replicated an association between increasing psychosis RPS and reduced IQ (matrix reasoning: corrected P = .003 for RPS model 2, 0.4% variance explained), supporting the validity of the psychosis RPS models. We also found a nominally significant association between increased psychosis RPS and reduced MID task performance (uncorrected P = .03 for RPS model 4, 0.2% variance explained). Our main finding was a positive association between psychosis RPS and VS BOLD during reward anticipation at all 4 psychosis RPS models and for 2 P thresholds for reward receipt (RPS models 1 and 3), correcting for the familywise error rate (0.8%-1.9% variance explained).These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual's response to rewarding stimuli.
Histochemical Demonstration of Acid Phosphatases With Naphthol AS-Phosphates
Authors: M. S. Burstone
Journal: JNCI Journal of the National Cancer Institute (1958)

A simple, reliable, and convenient azo-dye method for the demonstration of acid phosphatase and phosphamidase in paraffin-embedded tissues is described. The best results are obtained with frozen-dried tissues. Phosphates of naphthols AS-BI, AS-BS, AS-LC, and AS-TR are useful substrates (text-fig. 1, II). The stability and potential high chromogenicity of these substrates suggest their use in quantitative determinations. The present study indicates that acid phosphatase is not as sensitive an enzyme as previously assumed, and that with reasonable care it can be preserved even in mounted sections over a long period.
Efficacy of crizotinib in ROS1-rearranged lung cancer: The European experience.
Authors: Julien Mazieres, Gerard Zalcman, Lucio Crino, Pamela Biondani, Benjamin Besse, Anne-Marie C. Dingemans, Hervé Lena, Isabelle Monnet, Sacha Rothschild, Federico Cappuzzo, Luc Thiberville, Damien Rouvière, Rafal Dziadziuszko, Egbert F. Smit, Juergen Wolf, Christian Spirig, Nicolas Pécuchet, Joachim Diebold, Julie Milia, Oliver Gautschi
Journal: Journal of Clinical Oncology (2014)

11035 Background: ROS1 chromosomal rearrangement (ROS1+) was described as an oncogenic driver in approximately 1% of non-small cell lung cancers (NSCLC). Due to the structural analogy of ROS1 and ALK, crizotinib is a potent inhibitor of both targets. An expansion cohort of a phase I trial reported promising activity [Ou et al., ASCO 2013]. Here, we describe the characteristics and outcomes of ROS1+ NSCLC patients treated with crizotinib in a large European case series. Methods: We conducted a retrospective study among European clinicians screening ROS1+ NSCLC. Eligible patients had advanced NSCLC, known ROS1+ NSCLC diagnosed by FISH and received crizotinib for at least 1 week at the dose of 250 mg BID through national access program or an individual off-label use basis. Treatment response was performed according to RECIST criteria version 1.1. Informed consent and IRB approval were obtained according to local regulations. Data were analyzed centrally. Results: We identified 28 ROS1+ NSCLC patients treated with crizotinib. Our population was characterized by a median age of 58 yr (34 to 78 yr), a gender-ratio of 17 women and 11 men and a high proportion of never smokers (n = 19, 67.9%). All the patients had stage IV disease and were pretreated with none (n=2), one (n = 8), two (n = 5), three (n = 3) or more (n = 10) lines of chemotherapy before the administration of crizotinib. All tumors were adenocarcinomas including 4 with lepidic pattern. ROS1 rearrangement was the exclusive driver except for 2 tumors with concomitant KRAS mutation. Twenty-six patients were evaluable for response (the waterfall plot will be presented at the meeting). We observed 3 progressive diseases, 3 stable diseases and 20 objective responses including 4 complete responses (overall response rate 77%, disease control rate 88%). Crizotinib primary resistance was associated with concomitant KRAS mutation or progression in the brain. Crizotinib was generally well tolerated and no unexpected adverse effects were observed. Conclusions: These results confirm the high crizotinib activity in ROS1+ NSCLC. Further patients should be treated in ongoing clinical trials to test the long-term activity of ROS1 inhibitors.
Outcome Of Standard Risk B-Precursor Acute Lymphoblastic Leukemia Treated Following The Children’s Cancer Group-1991 (CCG-1991) Study: Experience From a Single Center In Saudi Arabia
Authors: Wasil Jastaniah, Naglla Elimam, Khalid Abdalla, Mohammed Burhan Abrar, Taha Khattab, Basheer Ahmed Cittana Iqbal, Sami Felimban
Journal: Blood (2013)
Abstract 3122: Differences in Intima Media Thickness of the Common and Internal Carotid Arteries
Authors: Joseph F Polak, Michael J Pencina, Karol M Pencina, Lisa S Brown, Philip A Wolf, Ralph B D'Agostino
Journal: Circulation (2008)

Purpose: Carotid artery intima media thickness (IMT) measurements are recognized as a surrogate marker of atherosclerosis. In risk assessment, it is not clear if IMT measurements should focus on th...
Neoadjuvant Endocrine Therapy for Estrogen Receptor–Positive Breast Cancer
Authors: Laura M. Spring, Arjun Gupta, Kerry L. Reynolds, Michele A. Gadd, Leif W. Ellisen, Steven J. Isakoff, Beverly Moy, Aditya Bardia
Journal: JAMA Oncology (2016)

<h3>Importance</h3> Estrogen receptor–positive (ER+) tumors of the breast are generally highly responsive to endocrine treatment. Although endocrine therapy is the mainstay of adjuvant treatment for ER+ breast cancer, the role of endocrine therapy in the neoadjuvant setting is unclear. <h3>Objective</h3> To evaluate the effect of neoadjuvant endocrine therapy (NET) on the response rate and the rate of breast conservation surgery (BCS) for ER+ breast cancer. <h3>Data Sources</h3> Based on PRISMA guidelines, a librarian-led search of PubMed and Ovid MEDLINE was performed to identify eligible trials published from inception to May 15, 2015. The search was performed in May 2015. <h3>Study Selection</h3> Inclusion criteria were prospective, randomized, neoadjuvant clinical trials that reported response rates with at least 1 arm incorporating NET (n = 20). Two authors independently analyzed the studies for inclusion. <h3>Data Extraction and Synthesis</h3> Pooled odds ratios (ORs), 95% CIs, and<i>P</i>values were estimated for end points using the fixed- and random-effects statistical model. <h3>Results</h3> The analysis included 20 studies with 3490 unique patients. Compared with combination chemotherapy, NET as monotherapy with aromatase inhibitors had a similar clinical response rate (OR, 1.08; 95% CI, 0.50-2.35;<i>P</i> = .85; n = 378), radiological response rate (OR, 1.38; 95% CI, 0.92-2.07;<i>P</i> = .12; n = 378), and BCS rate (OR, 0.65; 95% CI, 0.41-1.03;<i>P</i> = .07; n = 334) but with lower toxicity. Aromatase inhibitors were associated with a significantly higher clinical response rate (OR, 1.69; 95% CI, 1.36-2.10;<i>P</i> &lt; .001; n = 1352), radiological response rate (OR, 1.49; 95% CI, 1.18-1.89;<i>P</i> &lt; .001; n = 1418), and BCS rate (OR, 1.62; 95% CI, 1.24-2.12;<i>P</i> &lt; .001; n = 918) compared with tamoxifen. Dual combination therapy with growth factor pathway inhibitors was associated with a higher radiological response rate (OR, 1.59; 95% CI, 1.04-2.43;<i>P</i> = .03; n = 355), but not clinical response rate (OR, 0.76; 95% CI, 0.54-1.07;<i>P</i> = .11; n = 537), compared with endocrine monotherapy. The incidence of pathologic complete response was low (&lt;10%). <h3>Conclusions and Relevance</h3> Neoadjuvant endocrine therapy, even as monotherapy, is associated with similar response rates as neoadjuvant combination chemotherapy but with significantly lower toxicity, suggesting that NET needs to be reconsidered as a potential option in the appropriate setting. Additional research is needed to develop rational NET combinations and predictive biomarkers to personalize the optimal neoadjuvant strategy for ER+ breast cancer.
Derniers échos sur les activités et résultats d’EARSS
Authors: U Buchholz, S L A M Bronzwaer, P Schrijnemakers, J Monen, J. L. Kool
Journal: Eurosurveillance (2001)

Les derniers resultats (1999–2000) d’EARSS suggerent que les taux de S. aureus resistant a la meticilline et de S. pneumoniae de sensibilite reduite a la penicilline sont plus eleves dans les pays du sud de l’Europe que dans ceux du nord. Pour les souches S. pneumoniae de sensibilite reduite a la penicilline, le groupe le plus a risque est celui des jeunes enfants, suivi des personnes âgees. Le risque d’etre infecte par une souche de S. aureus meti-R augmente avec l’âge, les patients en services de soins intensifs etant plus exposes.
Trends in Methadone Distribution for Pain Treatment, Methadone Diversion, and Overdose Deaths — United States, 2002–2014
Authors: Christopher M. Jones, Grant T. Baldwin, Teresa Manocchio, Jessica O. White, Karin A. Mack
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Use of the prescription opioid methadone for treatment of pain, as opposed to treatment of opioid use disorder (e.g., addiction), has been identified as a contributor to the U.S. opioid overdose epidemic. Although methadone accounted for only 2% of opioid prescriptions in 2009 (1), it was involved in approximately 30% of overdose deaths. Beginning with 2006 warnings from the Food and Drug Administration (FDA), efforts to reduce methadone use for pain have accelerated (2,3). The Office of the Assistant Secretary for Planning and Evaluation of the U.S. Department of Health and Human Services and CDC analyzed methadone distribution, reports of diversion (the transfer of legally manufactured methadone into illegal markets), and overdose deaths during 2002-2014. On average, the rate of grams of methadone distributed increased 25.1% per year during 2002-2006 and declined 3.2% per year during 2006-2013. Methadone-involved overdose deaths increased 22.1% per year during 2002-2006 and then declined 6.5% per year during 2006-2014. During 2002-2006, rates of methadone diversion increased 24.3% per year; during 2006-2009, the rate increased at a slower rate, and after 2009, the rate declined 12.8% per year through 2014. Across sex, most age groups, racial/ethnic populations, and U.S. Census regions, the methadone overdose death rate peaked during 2005-2007 and declined in subsequent years. There was no change among persons aged ≥65 years, and among persons aged 55-64 years the methadone overdose death rate continued to increase through 2014. Additional clinical and public health policy changes are needed to reduce harm associated with methadone use for pain, especially among persons aged ≥55 years.
Response to ‘Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis’ by Rühlemann<i>et al</i>
Authors: Martin Kummen, Johannes R Hov
Journal: Gut (2016)

We read with great interest and enthusiasm the letter from Ruhlemann et al 1 regarding the possible diagnostic role of the faecal microbial profile in primary sclerosing cholangitis (PSC). In the study, 73 well-characterised patients with PSC were compared with 98 healthy control (HC) subjects and 88 subjects with UC in order to validate a diagnostic panel of microbial markers identified in our recent study of PSC.2

Out of 12 taxa included in a diagnostic panel, 10 were also identified in the German dataset. Using these 10 taxa, Ruhlemann et al obtained the area under the curves (AUCs) of 0.86 and 0.79 for discriminating HC from PSC, and UC from PSC, respectively, validating …
&lt;emph type="ital"&gt;Niagara&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Functional state of endothelium in bronchial asthma children
Authors: Natalya Orlova, Esfir Atkina, Larisa Guryeva, Lubov Babenkova, Gulnara Sakaeva, Alfia Biktasheva, Svetlana Levasheva
Journal: European Respiratory Journal (2011)

To examine the association between the functional state of endothelium and bronchial asthma the oxide nitrogen (NO) condition in blood samples was evaluated in 118 bronchial asthma children with a wide range of desease severity with the use of Yemchenko L.N. method (1994) by determination of terminal stabile metabolites, and endothelin-1 (ET-1) concentration with enzyme immunoassays analysis, and also with the use of J. Hladovec method (1978) of circulation endothelial cells (CEC) level establishing. The credible increase of ET-1 (0,525±0,06 fmol/ml), NO (66,59±4,45 mkM/ml), CEC ( 7,28±0,63 cells/100 mkl) levels in bronchial asthma children compared with control (0,22±0,01 fmol/ml, 29,86±0,77 mkM/ml, 3,03±0,22 accordingly, p<0,01). The levels of endothelial markers credibly decreased on the background of anti-inflammatory therapy by inhalative glucocorticosteroids (NO 82,69±14,38 mkM/ml and 42,12±9,66 mkM/ml, p=0,001; ET-1 0,64±0,15 fmol/ml and 0,35±0,06 fmol/ml, p=0,001; CEC 7,3±1,67 and 5,0±0,32 cells/100 mkl p=0,0017). All the trial results may be used as an additional standard definition of bronchial asthma severity and therapeutic efficiency in bronchial asthma children.
Public health implications of influenza B outbreaks in closed settings in the United Kingdom in the 2007/08 influenza season
Authors: P Mook, J Ellis, J  M Watson, CI Thompson, M Zambon, J McMenamin, B Smyth, DRh Thomas, R  G Pebody
Journal: Eurosurveillance (2008)

Several influenza B outbreaks occurred in closed settings late in the 2007/08 influenza season (October to mid-May) in the United Kingdom (UK), with implications for public health management. Influenza B viruses usually circulate late in the season and cause a milder disease than influenza A viruses [1]. Epidemics of influenza B usually occur every two to three years with the burden of disease falling predominantly on school-aged children [2].
Secreted Frizzled-Related Protein 4 (SFRP4): A Novel Biomarker of β-Cell Dysfunction and Insulin Resistance in Individuals With Prediabetes and Type 2 Diabetes
Authors: Kaviya Anand, Sudha Vidyasagar, Ian Lasrado, Gautam Kumar Pandey, Anandakumar Amutha, Harish Ranjani, Ranjit Mohan Anjana, Viswanathan Mohan, Kuppan Gokulakrishnan
Journal: Diabetes Care (2016)

Studying biomarkers early could help to identify high-risk individuals who could be targeted for the prevention of type 2 diabetes (T2D). Secreted frizzled-related protein 4 (SFRP4) is highly expressed in the islets, and its levels are increased several years before diabetes diagnosis (1). We report here on the systemic levels of SFRP4 and its association with insulin resistance and β-cell dysfunction.

Individuals with normal glucose tolerance (NGT; n = 100), impaired glucose tolerance (IGT; n = 60), and T2D ( n = 100) were recruited from a large tertiary diabetes center in Chennai and a medical college hospital at Manipal in southern India. NGT, IGT, and T2D were defined using World Health Organization consulting group criteria (2). β-Cell function and insulin resistance were calculated by the oral disposition index (DIo) and the HOMA of insulin resistance (HOMA-IR), respectively. SFRP4 levels were measured by ELISA. …
The Medical Treatment of Peptic Ulcer.
Authors: R S NELSON
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal