tbuckley/cabot-search huggingface dataset:
Abstract P3-11-09: Body Mass Index (BMI) and Survival: A Retrospective Review of Women with Triple Negative Breast Cancer (An Update)
Authors: A Sudhindra, D Dammarich, R Ochoa, C Takita, MF Mendiola, J Hurley, S Gluck, C Welsh, J Slingerland, S Richman, C Gomez-Fernandez, P Timothee, A Diaz, OE. Silva
Journal: Cancer Research (2010)

Abstract Body Mass Index (BMI) has been reported as a risk factor for recurrence and decreased survival in women with breast cancer. At the Inter-American Breast Cancer Conference we presented data showing the effect BMI has on overall survival in women with triple negative breast cancer (TNBC). Here we present an update of this data which to our knowledge is the only study addressing the effect BMI has on outcomes in TNBC. We conducted a retrospective review of 170 patients with TNBC seen at the University of Miami Sylvester Comprehensive Cancer Center and Jackson Memorial Hospital between December of 1999 and April 2010. Charts were reviewed looking at BMI at the time of diagnosis and overall survival defined as date of last contact or date of death when known. 163 patients were included in the study. BMI was defined as normal (BMI 18.5-24.9) and overweight or obese (25 or greater). The average age at diagnosis was 50.96 years with a mean OS of 44.67 months. 21 patients (13%) had stage I disease, 61 (37.4%) had stage II disease, 81 (49.6%) had stage III disease. In patients with stage I disease 33% had a normal BMI with a mean OS of 51.7 months. 67% were overweight or obese with a mean OS of 60.2 months. In patients with stage II disease 33% had a normal BMI with a mean OS of 30.8 months. 67% were overweight or obese with a mean OS of 48.4 months. In patients with stage III disease 28% had a normal BMI with a mean OS of 37.2 months. 72% were overweight or obese with a mean OS of 43.1 months. Survival in patients with TNBC does not appear to be negatively impacted by the patients BMI at diagnosis. While not statistically significant (p=0.274) patients with stage I TNBC that were overweight or obese tended to have an increased OS compared to those with a normal BMI. In patients with stage II disease there was a statistically significant (p=0.010) increase in OS in overweight or obese patients compared to those with a normal BMI. In the patients with stage III disease there was no significant difference in the OS (p=0.458) between patients with a normal BMI and those that were overweight or obese. Our study shows that increased BMI at the time of diagnosis may have a positive impact on OS in patients with TNBC. Overweight and obese patients with stage I and II TNBC have an increased OS compared to those with a normal BMI. In those with stage II disease the difference was statistically significant. Although this study was limited by small sample size, if confirmed, it might suggest a relationship between obesity and survival in TNBC. Further studies are needed to evaluate these findings. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-11-09.
Abstract ES6-1: Quantitative Methods To Assess Eligibility for Breast Cancer Therapy
Authors: Rimm DL
Journal: Cancer Research (2010)

Abstract Breast cancer is one of the few tumors where the judgment of level of protein expression by immunohistochemistry (IHC) directly results in therapy. Although the pathologist is not the prescribing physician, their “reading” of ER, PR, and Her2 can result in prescription of life-saving therapies. As a result of that, many studies have been done to attempt to be more quantitative in the assessment of exactly how much protein is on the slide. However, these efforts have largely failed to gain clinical acceptance, even up to April 2010, when the ASCO/CAP guidelines recommended, but did not require, a quantitative approach. Key reasons for the hesitation to require quantification included lack of standardization, lack of data on pre-analytic variables and lack of a universally accepted reproducible quantitative method. This presentation will examine the current methods for quantitative measurement of ER and Her2 in breast cancer tissue including review of the current technologies and devices for both IHC and quantitative immunofluorescence (QIF). Then issues and some new data related to standardization and pre-analytic variability will be presented. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr ES6-1.
AB0555 Cardiovascular Risk Assessment in A SLE Cohort – Where do We Stand?
Authors: T. Meirinhos, J. Caniço, R. Aguiar, C. Ambrόsio, A. Barcelos
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The pathogenesis of cardiovascular risk in Systemic Erythematosus Lupus (SLE) is the result of a complex interaction between traditional risk factors, disease specific factors and chronic inflammation. To minimize de cardiovascular risk in these patients, doctors should control every risk as possible, to avoid an increase in the mortality and morbidity. <h3>Objectives</h3> In order to implement a follow-up protocol in our SLE patients, the authors made a transversal assessment on cardiovascular risk factors, and how they are controlled, or not, in a SLE cohort. <h3>Methods</h3> A convenient sample of outpatients with SLE attending our Rheumatology Clinic was recruited. Clinical and laboratorial data were collected using the hospital information records. Statistical analysis was performed using Excel. <h3>Results</h3> 60 patients were enrolled (54 women and 6 men), with a mean age of 41,1 years and a mean disease duration of 7,4 years. Mean SLEDAI was 2.86±3.36. 13 patients had smoking habits and 22 patients were overweight, but there were no available data of the weigh or height of 21 patients. 12 patients had a blood pressure superior to 130/80 mmHg. Only 5 patients were insulin resistant, none was diabetic. Mean creatinine was 0,81 mg/dl and albumin 3,9 g/dl. 25 patients had proteinuria &gt;300mg/24 hours. Mean C-reactive protein was 0,73 mg/dl. Concerning cholesterol levels in this SLE patient9s cohort: 21 had LDH&gt;100 mg/dl, 12 total cholesterol&gt;200 mg/dl, 7 HDL&lt;40 mg/dl and 5 had triglycerides&gt;150 mg/dl. 7 patients had no lipid profile in the last year. 12 patients were medicated with statins and 28 with angiotensin –converting enzyme inhibitors or angiotensin receptor blockers. The mean dose of corticosteroid was 5.6 mg pd. In this SLE cohort, there were 8 thrombotic vascular events but 5 of these patients had also antiphospholipid syndrome. <h3>Conclusions</h3> The results reinforce the importance of a protocolled follow-up that could avoid the lack of some important clinical and laboratorial data and a better/more efficient control of co-morbidities in SLE patients. <h3>References</h3> Magder LS, Petri M. Incidence of and risk factors for adverse cardiovascular events among patients with systemic lupuserythematosus. Am J Epidemiol. 2012 Oct 15;176(8):708-19 <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4626
THU0313 Impaired Pre-Attentive Auditory Processing in Fibromyalgia: A Mismatch Negativity Study
Authors: H.A. Kim, W. Choi, C.-K. Chung
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Fibromyalgia (FM) is characterized by chronic widespread pain. Patients are more sensitive to sensory stimulation regardless of type and modality, suggesting generalized dysfunction in sensory processing. Mismatch Negativity (MMN) is an event-related potential measuring pre-attentive auditory processing. <h3>Objectives</h3> The present study aimed to explore pre-attentive auditory processing, which might be affected as a part of generalized sensory processing dysfunction in FM by measuring MMN in FM patients and healthy controls (HC). Also we tried to find an association between MMN parameters and pain sensitivity in FM patients. <h3>Methods</h3> Auditory evoked fields were recorded using magnetoencephalography in 18 right-handed female FM patients and 21 age-, sex- and education-matched right handed HC during a duration-deviant auditory oddball paradigm (50-ms standard and 100-ms deviant tones). The magnetic counterpart of the MMN (MMNm) was obtained by subtracting the response to standard stimuli from the response to deviant stimuli. Peak latencies, amplitudes and directional asymmetry coefficient (AC) of the MMNm source were compared between two groups. Pressure pain threshold over the thenar and trapezius muscle was assessed for measuring pain sensitivity. <h3>Results</h3> FM patients exhibited reduced MMNm amplitude in the right hemisphere. Rightward asymmetry of MMNm was altered in FM patients indexed by lower AC values. Also, smaller right MMNm amplitude was associated with lower pressure pain threshold of thenar muscle in FM patients. <h3>Conclusions</h3> Pre-attentive auditory processing was compromised in FM indexed by reduced MMNm amplitude. This result suggests likelihood of generalized sensory processing dysfunction in FM. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4728
881 HIGH SVR RATES (SVR4) FOR 12-WEEK TOTAL TELAPREVIR COMBINATION THERAPY IN IL28B CC TREATMENT-NAÏVES AND PRIOR RELAPSERS WITH G1 CHRONIC HEPATITIS C: CONCISE INTERIM ANALYSIS
Authors: D.R. Nelson, F. Poordad, J.J. Feld, M.W. Fried, I.M. Jacobson, P.J. Pockros, M.S. Sulkowski, S. Zeuzem, L. Bengtsson, S. George, M.I. Friedman
Journal: Journal of Hepatology (2013)
Incidental Detection of Single Vertebral Osteomyelitis in a Patient Operated on for Parathyroid Hyperplasia
Authors: T F Cermik, M Yüksel, E Yalniz, M Kaya, B Uğur, A Tuğrul, S Berkarda
Journal: Clinical Nuclear Medicine (2001)

FIKRET ÇERMIK, T. M.D.*; YÜKSEL, MAHMUT M.D.*; YALNIZ, EROL M.D.†; KAYA, MERYEM M.D.*; UĞUR, BETÜL M.D.*; TUĞRUL, ARMAĞAN M.D.‡; BERKARDA, ŞAKIR M.D.* Author Information
A Personalized Care Platform: Incorporating Structured Data In Allergy Clinical Care
Authors: J. Meng, C. Barnes, C. Ciaccio, J. Portnoy, K. Kelly, G.A. Salzman, T. Carver, P. Dowling, B. Jones, M. Amado, C. Miller, K. Kennedy, L.J. Rosenwasser
Journal: Journal of Allergy and Clinical Immunology (2012)
Maintaining registers that provide reliable and valid information is not easy
Authors: R. Smith, R. Johnston
Journal: BMJ (2013)

In publishing risk adjusted mortality rates by hospital and surgeon, the Society for Cardiothoracic Surgeons in Great Britain and Ireland sets a standard to which other surgical specialties should aspire.1 However, careful statistical analysis is needed for valid comparisons between hospitals or surgeons, even for a binary outcome such as death. The analysis will lose the confidence of surgeons and …
ASSOCIATION OF PERIARTERIAL NEOVASCULARIZATION WITH PROGRESSION OF CARDIAC ALLOGRAFT VASCULOPATHY AND LONG-TERM CLINICAL OUTCOMES IN HEART TRANSPLANT RECIPIENTS
Authors: Hideki Kitahara, Kozo Okada, Shigemitsu Tanaka, Hyoung-Mo Yang, Yuhei Kobayashi, Takumi Kimura, Helen Luikart, Paul Yock, Alan Yeung, Peter Fitzgerald, Kiran Khush, William Fearon, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2015)
Three cases of pancreatic pseudocysts mimicking mucinous cystadenoma and pancreatic cancer on Endoscopic Ultrasound
Authors: Kim Sae Hee
Journal: Endoscopy (2011)

Purpose: Pancreatic pseudocysts, which account for 70 to 90% of pancreatic cystic lesions, are non-epithelially lined cystic cavities contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute, chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances, especially macrocystic neoplasms. We report three cases of pancreatic pseudocysts mimicking mucinous cystadenomas and pancreatic cancer.
GENDER DISPARITIES IN CARDIOVASCULAR CARE ACCESS AND DELIVERY IN INDIA: INSIGHTS FROM THE AMERICAN COLLEGE OF CARDIOLOGY'S PINNACLE INDIA QUALITY IMPROVEMENT PROGRAM (PIQIP)
Authors: Ankur Kalra, Yashashwi Pokharel, Nathan Glusenkamp, Jessica Wei, Vikas Thakran, Prafulla G. Kerkar, William Oetgen, Salim Virani
Journal: Journal of the American College of Cardiology (2016)
Abstract 3953: Senescence induced of smooth muscel protein 22-alpha (SM22) and Radiation patients change human-link genes expression level
Authors: Myeong Ok Kim, Younjoo Kim, Younmi Ko
Journal: Cancer Research (2012)

Abstract P53 and RB protein is famous for its capacity to suppress tumor senescence pathway member. Senescence is a leading cause of cancer-related death, considerable uncertainty still remains about their effectiveness. However, each marker in an increased risk that experience genomic data with a cancer-specific mutations. So, senescence marker that techniques can't develop patient-specific treatment for particular about experimental study-conditions and result-analysis. This study was undertaken to evaluate the sm22 (smooth muscel protein 22-alpha) protein relation of senescence marker and changes condition of the radiation at human-link senescence marker genes. We were determined the expression of senescence-associated β-galactosidase and western-blot assay. It was performed in colon cancers that were 17 patients each of normal and adenoma, 16 patients each of normal and adenocarcinoma. To conformed enzyme efficiency is β-galactosidase, senescence pathway using of p16, p21 and p53. On the other hand, sm22 use of senescence marker in study. we have decided to micro-array analysis that 3 patients each of normal and adenoma, 2 patients each of normal and adenocarcinoma, 2 patients each of normal and irradiation-adenocarcinoma (2 weeks after) available miRNA sequences on the Agilent Human whole genome 8x60K array chip. Gene expression levels were calculated with Feature Extraction v10.7.3.1 (Agilent technologies, CA) Relative signal intensities for each gene were generated using the Robust Multi-Array Average algorithm. Senescence induced p16 expression in dependent β-galactosidase assay results, sm22 protein suppressed cellular senescence levels as well as p16 protein. The expression of p16 and sm22 was analyzed that not involved each normals, adenomas and adenocarcinomas tissue by western blot analysis. In addition, it found that these results were similar to those of micro array. The three groups (adenoma, adeno-carcinoma and irradiation-adeno-carcinoma) can be compared in terms of total 2-fold changed gene (least 200% of controls for up-regulated and lower than 50% of controls for down-regulated genes). We found this integrative data analysis tool to the LCN2, LYPD5 and LOC100132051 genes as well as CDKN2 (p16) and TAGLN2 (sm22) gene expression. Irradiation groups was much less than the adenoma (45.3 %) and adenocarcinoma (71.1 %) 2-fold changed gene expression. The LCN2, LYPD5 and LOC100132051 genes lower than adeno-carcinoma group level. Our observations suggest that shared gene and protein expression profiles may contribute to sm22 and p16 of senescence marker, irradiation induces cellular senescence of colon cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3953. doi:1538-7445.AM2012-3953
FRI0312 The cross-sectional and longitudinal associations between radiographic features and joint tenderness in hand osteoarthritis:
Authors: I.K. Haugen, B. Slatkowsky-Christensen, P. Bøyesen, D. van der Heijde, T.K. Kvien
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Longitudinal studies have shown no associations between increased amount of radiographic hand osteoarthritis (OA) and more hand pain. <h3>Objectives</h3> We therefore aimed to study whether radiographic hand OA was related to joint tenderness in cross-sectional and longitudinal settings with focus on joint-specific analyses. <h3>Methods</h3> We included 200 patients (182 women, mean (SD) age 61.5 (5.8) years) from the Oslo hand OA cohort, of which 102 had 7-years follow-up data. The bilateral distal and proximal interphalangeal and carpometacarpal joints were scored for radiographic OA according to the Kellgren-Lawrence scale and OARSI atlas for assessment of individual features (osteophytes and joint space narrowing (JSN) grade 0-3, and absence/presence of erosions, cysts, sclerosis and malaligment). The same joints were clinically examined for tenderness on palpation. The associations between radiographic hand OA and tenderness in the same joint were examined by uni-/multivariate logistic regression analyses with Generalized Estimating Equations. In the longitudinal analyses we included joints with potential for radiographic progression and without tenderness at baseline. Features that were associated with joint tenderness in univariate analyses (p&lt;0.20) were included in a multivariate model and excluded by backward selection. Analyses were adjusted for age and sex. <h3>Results</h3> Increasing severity of radiographic OA was associated with higher odds of tenderness, and joints that progressed into severe radiographic OA had the highest odds of developing tenderness during follow-up (table). Progression of osteophytes and JSN were associated with incident tenderness, but incident erosions seemed to the most important predictor for incident tenderness. Sclerosis and cysts were not associated with tenderness in the multivariate models, and malalignment remained in the multivariate model for cross-sectional data only (table). <h3>Conclusions</h3> Radiographic hand OA is associated with tenderness in the same joint, and erosive development can strongly predict future joint tenderness. <h3>Disclosure of Interest</h3> None Declared
MOLECULAR-BASED GRADING IN IDH-MUTANT LOWER GRADE GLIOMAS
Authors: K. Aldape, G. Zadeh, E. Sulman
Journal: Neuro-Oncology (2014)

BACKGROUND: As diffuse grade II-III gliomas are further characterized using genome-wide studies, additional markers could be used clinically to stratify patients into distinct risk groups A rational grading system for lower grade gliomas might account for IDH status, since this marker defines 2 biologic groups of diffuse gliomas. Methylation profiling using the Illumina 450k array provides a source of possible biomarkers for patient outcome. This study examined factors associated with prognosis in IDHmut tumors from the TCGA LGG study. METHODS: Illumina 450k data and associated clinical were available on 164 cases in the TCGA LGG study. Average beta-values in clinically favorable versus unfavorable outcome patients for progression-free and overall survival (using cutoffs of 2 years and 5 years, respectively) were calculated from the highly variable CpG sites among the 164 samples. Approximately 800 CpG sites showed a fold change of >1.5 or <0.7, at a significance level <0.1 in both OS and PFS analyses and among those 14 genes, (representing 38 CpG sites) showed representation of multiple CpG sites within the CpG island of the gene. RESULTS: Patient age and 1p/19q status were associated with outcome in univariate analyses for IDHmut cases (p < 0.05 for both PFS and OS) but interestingly WHO grade was not associated with outcome (p > 0.2 for both). A score from the 38 markers was calculated and high methylation score-cases showed improved outcome compared to low methylation score-cases for both PFS (7.1 years vs. 3.1 years) and OS (9.0 years vs. 4.5 years, both p < 0.01, log rank). In multivariate analysis, methylation score remained significantly associated with outcome (p < 0.01) after adjustment for patient age and 1p/19q status. Interestingly, the prognostic methylation score derived from IDHmut cases was not prognostic when applied to IDHwt cases. CONCLUSIONS: WHO histologic grade (II vs. III) may not be optimal for IDHmut diffuse gliomas, indicating a need for alternative modalities to stratify patients into clinically distinct risk groups. Genome-wide studies, including Illumina 450k data offer a promising source of markers. As more cases and data are analyzed, additional markers will be identified from TCGA data and this study provides proof-of-principle that set of markers from can be identified that stratifies distinct risk groups of patients with IDHmut tumors. Future stratification of diffuse gliomas into clinical risk groups should account for distinct biologic subtypes based on early genetic lesions such as IDH status. SECONDARY CATEGORY: n/a.
Ga-67 and Tl-201 Accumulation in Squamous Cell Carcinoma of the Thyroid
Authors: K Usui, N Shuke, W Yamamoto, T Aburano, T Goto, Y Harabuchi, N Miyokawa
Journal: Clinical Nuclear Medicine (2000)

A 64-year-old man was hospitalized for examination of a neck tumor. A computed tomographic (CT) scan showed a thyroid tumor, including calcification and cystic changes in the right lobe, and soft tissue density masses were seen in the neck and mediastinum. Tc-99m pertechnetate imaging showed a defect in the area corresponding to the mass seen on CT. Tl-201 imaging showed marked accumulation in the mass both in the early and delayed images. On Ga-67 imaging, there was accumulation comparable to that seen with Tl-201 in the same area. Surgical biopsy revealed that the tumor was squamous cell carcinoma. Because no other primary lesion was detected, the lesion was thought to be thyroid in origin.
Pulmonary Atresia With Intact Septum
Authors: D J Fisher, S L Ferency, D M Rosenbaum, J P McCloskey
Journal: Clinical Nuclear Medicine (1997)

Right ventricular size in cases of pulmonary atresia is determined by blood flow into and out of the right ventricle. A hypoplastic or enlarged right ventricle can result. In cases of an intact septum, elevated right ventricular pressure results in retrogated flow of blood from a blind-ending right ventricle into the coronary artery circulation via enlarged myocardial sinusoids. In some cases, no connection exists between the coronary arteries and the aorta. Stress sestamibi myocardial perfusion scan is helpful in determining if myocardium is at risk for ischemia or infarction in cases in which coronary circulation is influenced by right ventricular-coronary artery communications.
Erythropoietin for the Treatment of Porphyria Cutanea Tarda in a Patient on Long-Term Hemodialysis
Authors: Karl E. Anderson, Douglas E. Goeger, Richard W. Carson, Shung-Man K. Lee, Richard B. Stead
Journal: New England Journal of Medicine (1990)

PORPHYRIA cutanea tarda, which is the most common and readily treated form of porphyria in humans, results from a deficiency of uroporphyrinogen decarboxylase in the liver.1 2 3 It is characterized by cutaneous photosensitivity. The disease is usually classified as sporadic if uroporphyrinogen decarboxylase is deficient only in the liver, and as familial (autosomal dominant) if the enzyme is also deficient in nonhepatic tissues such as erythrocytes.3 4 5 There is also a familial form in which only the hepatic enzyme is deficient.6 Increased iron content in the liver is a major contributing factor in both sporadic and familial porphyria cutanea tarda,7 as are . . .