tbuckley/cabot-search huggingface dataset:
FRI0080 Racial Disparities in Total Ankle Arthroplasty Utilization and Outcomes
Authors: J.A. Singh, R. Ramachandran
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Studies of racial disparities in total ankle arthroplasty are lacking. <h3>Objectives</h3> Our objective was to study the racial disparities in total ankle arthroplasty (TAA) utilization and outcomes. <h3>Methods</h3> We used the Nationwide Inpatient Sample (NIS) to study the time-trends. Race was categorized as White and Black. Utilization rates were calculated for the U.S. general population per 100,000. Hospital length of stay, discharge disposition and mortality after TAA were assessed. We used the Cochran Armitage trend test to assess time-trends from 1998 to 2011 and chi-square test to compare TAA utilization. We used analysis of variance or chi-squared test to compare the characteristics of Whites and Blacks undergoing TAA and logistic regression to compare mortality, length of stay and discharge to home vs medical facility. <h3>Results</h3> The mean ages for Whites undergoing TAA were 62 years and for Blacks was 52 years. Significant racial disparities were noted in TAA utilization rates (/100,000) in 1998, 0.14 in Whites vs. 0.07 in Blacks (p&lt;0.0001; 2-fold) and in 2011, 1.17 in Whites vs. 0.33 in Blacks (p&lt;0.0001; 4-fold). Racial disparities in TAA utilization increased significantly from 1998 to 2011 (p&lt;0.0001). There was a trend towards statistical significance in the length of hospital stay in Blacks vs. Whites (52.9% vs. 44.3% with length of hospital stay higher than the median; p=0.08). Differences in the proportion discharged to an inpatient medical facility after TAA, 16% Blacks vs. 13% Whites, were not significant (p=0.47) <h3>Conclusions</h3> This study demonstrated significant racial disparities with lower TAA utilization and suboptimal outcomes in Blacks compared to Whites. Further studies are needed to understand the mediators of these disparities and to assess whether these mediators can be targeted to reduce racial disparities in TAA. <h3>Acknowledgements</h3> This material is the result of work supported by the resources and use of facilities at the Birmingham VA Medical Center, Alabama, USA. J.A.S. is also supported by grants from the Agency for Health Quality and Research Center for Education and Research on Therapeutics (CERTs), National Institute of Arthritis, Musculoskeletal and Skin Diseases (NIAMS), National Institute of Aging (NIA) and National Cancer Institute (NCI). <h3>Disclosure of Interest</h3> J. Singh Grant/research support from: takeda, savient, Consultant for: takeda, Savient, Allergan, Regeneron, R. Ramachandran: None declared
Brief Communication: An In Vitro Micromethod for Testing Cytotoxic Compounds2
Authors: Alexander S. Pacsa
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Brief Communication: An In Vitro Micromethod for Testing Cytotoxic Compounds Get access Alexander S. Pacsa Alexander S. Pacsa 3Virus Laboratory, Institute of Microbiology, University Medical School, Pees, 7643 Hungary. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 5, November 1974, Pages 1399–1401, https://doi.org/10.1093/jnci/53.5.1399 Published: 01 November 1974 Article history Received: 04 June 1974 Accepted: 18 July 1974 Published: 01 November 1974
Effect of 2-Ethylamino-1,3,4-Thiadiazole on the Incorporation of Glycine into Urinary Purines and Uric Acid in Man
Authors: J E SEEGMILLER, A I GRAYZEL, L LIDDLE, J B WYNGAARDEN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SMOKING AND ESOPHAGEAL HISTOLOGY
Authors: F A KINGERY
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Associations Between Spondyloarthritis Features and Magnetic Resonance Imaging Findings: A Cross‐Sectional Analysis of 1,020 Patients With Persistent Low Back Pain
Authors: Bodil Arnbak, Anne Grethe Jurik, Kim Hørslev‐Petersen, Oliver Hendricks, Louise Thuesen Hermansen, Anne Gitte Loft, Mikkel Østergaard, Susanne Juhl Pedersen, Anna Zejden, Niels Egund, René Holst, Claus Manniche, Tue Secher Jensen
Journal: Arthritis & Rheumatology (2015)

Objective The Assessment of SpondyloArthritis international Society (ASAS) has previously published criteria for spondyloarthritis (SpA). In the Spines of Southern Denmark cohort, which included patients with persistent low back pain and an unknown proportion of patients with SpA, our objectives were 1) to estimate the prevalence of magnetic resonance imaging (MRI) findings and clinical features included in the ASAS criteria for SpA and 2) to explore the associations between MRI findings and clinical features. Methods We included patients ages 18–40 years with persistent low back pain who had been referred to the Spine Centre of Southern Denmark. We collected information on clinical features (including HLA–B27 and high‐sensitivity C‐reactive protein) and MRI findings in the spine and sacroiliac (SI) joints. Results Of 1,020 included patients, 537 (53%) had at least 1 of the clinical features included in the ASAS criteria for SpA. Three clinical features were common—inflammatory back pain according to the ASAS criteria, a good response to nonsteroidal antiinflammatory drugs (NSAIDs), and family history of SpA. The prevalence of these features ranged from 15% to 17%. Sacroiliitis on MRI according to the ASAS definition was present in 217 patients (21%). Of those 217 patients, 91 (42%) had the minimum amount of bone marrow edema required according to the ASAS definition (a low bone marrow edema score). The presence of HLA–B27, peripheral arthritis, a good response to NSAIDs, and preceding infection were independently positively associated with MRI findings in the SI joints (odds ratios [ORs] of 1.9–9.0). The remaining 8 clinical features were not positively associated with MRI findings. Importantly, only age was independently associated with low bone marrow edema score at the SI joints (OR of 1.1 per year). Conclusion In this population, 53% had at least 1 clinical feature included in the ASAS criteria for SpA, and 21% had sacroiliitis according to the ASAS definition; furthermore, the associations between the clinical and imaging domains were inconsistent. The results indicate a need for further investigation of the importance of these findings in SpA, including investigation of the minimum requirements for defining sacroiliitis on MRI.
David Oliver: The pundits who do doctors down
Authors: David Oliver
Journal: BMJ (2016)

Rigorous, lengthy medical training is a good thing. High levels of public trust in doctors don’t result from qualifications obtained like lottery tickets.1 Yet a select right wing commentariat with no credible background in healthcare argues that medics are overqualified, overpaid, or operating a cartel to increase income and status.

The Times newspaper quoted UK taxpayer costs of £560 000 (€735 000; $820 000) to train a consultant, conveniently forgetting the decade spent in paid employment, delivering clinical services night and day while studying for exams in “spare time.”

Henry Hill, of the Conservative Home blog, proposed an …
Uremic Leontiasis Ossea in a Patient With Chronic Renal Insufficiency Demonstrated on Bone Scintigraphy
Authors: Yeon-Hee Han, Hwan-Jeong Jeong, Seok Tae Lim, Myung-Hee Sohn
Journal: Clinical Nuclear Medicine (2016)

A 37-year-old woman with chronic renal insufficiency underwent bone scintigraphy to evaluate renal osteodystrophy (ROD). Markedly increased uptakes were shown in the maxilla and the mandible, which suggested extensive maxillary and mandibular hypertrophy. CT image revealed that diffuse bony thickening and ground-glass appearance in the skull, maxilla, and mandible with poor distinction of the corticomedullary junction. Whole-body bone scintigraphy images also demonstrated various skeletal characteristics of ROD. This case emphasizes the utility of bone scintigraphy for the surveillance of the whole body in ROD.
AB0021 PTPN22 C1858T Variant is a Risk Factor for Systemic Lupus Erythematosus but not for Rheumatoid Arthritis in the Algerian Population
Authors: S.S. Salah, D. Fodil, H. Iguerguezdaoune, H. Amroun, M. Benidir, M. Djennane, A. Moussa Mebarek, D. Hakem, D. Acheli, F. Mechid, C. Makhloufi-Dahou, H. Djoudi, M.C. Abbadi, R. Tamouza, S. Lefkir-Tafiani, N. Attal
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> PTPN22 is a protein phosphatase regulating negatively T-cell activation and participates in BCR signaling pathways. C1858T single nucleotide polymorphism (SNP) in PTPN22 encoding the R620W allele variant has been associated with autoimmunity as it leads to increased levels of auto reactive immature B cells, reduced BCR signaling and fewer B cells deletion. Genetic data strongly support the link between C1858T SNP and susceptibility to a number of autoimmune diseases including SLE, RA, type 1 diabetes, and auto immune thyroiditis. <h3>Objectives</h3> We analyzed the effects of functional PTPN22 C1858T polymorphism (rs2476601) on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) susceptibility in a in a group of Algerian affected patients. <h3>Methods</h3> We conducted a case-control study including 676 samples from 299 RA, 152 SLE patients compared to 225 sex-, age-, and ethnicity-matched healthy controls. The TaqMan allele discrimination assay was used for sample genotyping. Screening and characterization of autoantibody [Anti-nuclear antibodies (ANA), Anti-citrullinated peptide antibodies (ACPA) and Rheumatoid Factor (RF)] specificities were performed using immuno-assay tests. <h3>Results</h3> Our results showed a significant association between either 1858T allele (OR =3.34, 95% CI =1.06-12.38, pc =0.03) or 1858CT genotype (OR =3.43, 95% CI =1.07-12.83, pc =0.03) and susceptibility to SLE. However, no significant association was observed between this polymorphism and RA. Furthermore, after stratification according to autoantibody positivity, we found an association with either LES anti-dsDNA positive patients (pc =0.005) or LES anti-Ro/SSA60KDa positive patients (pc =0.01) compared with healthy controls. No association was found with positivity of ACPA and RF positive patients. <h3>Conclusions</h3> Our results suggest that the PTPN22 1858T allelic variant is associated with genetic susceptibility to SLE but not of RA in the Algerian population, and that it may contribute also to anti-dsDNA and anti-Ro/SSA60KDa autoantibody production. <h3>References</h3> Giltiay NV et al. (2012) B-cell selection and the development of autoantibodies. Arthritis Research &amp; Therapy 2012, 14(Suppl 4):S1, doi: 10.1186/ar3918. Bottini N et al. (2014) Tyrosine phosphatase PTPN22: multifunctional regulator of immune signaling, development, and disease. Annu Rev Immunol., 32, 83-119. Lea WW et al (2011) The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update. Lupus. 2011 Jan;20(1):51-7. <h3>Disclosure of Interest</h3> None declared
Probable cases of Crimean-Congo-haemorrhagic fever in Bulgaria: a preliminary report
Authors: A Kunchev, M Kojouharova
Journal: Eurosurveillance (2008)

Between 20 January and 10 April 2008, six probable Crimean-Congo-haemorrhagic fever (CCHF) cases were reported in the municipality of Gotse Delchev, in Blagoevgrad district.
Endoscopic and Percutaneous Treatment of Difficult Bile Duct Stones
Authors: H Neuhaus
Journal: Endoscopy (2003)

About 90 % of ductal stones can be extracted after endoscopic sphincterotomy (EST) with routine endoscopic maneuvers. The main reasons for failure are a difficult gastroduodenal or biliary anatomy, or impacted or excessively large stones which cannot be grasped with basket catheters. Various nonsurgical procedures complementary to endoscopic retrograde cholangiopancreatography (ERCP) are available for these selected cases. For each of these methods, risks and benefits must be weighed against a surgical common bile duct exploration.
Correlates of lateral ventricular size in chronic schizophrenia, II: biological measures
Authors: M F Losonczy, I S Song, R C Mohs, A A Mathé, M Davidson, B M Davis, K L Davis
Journal: American Journal of Psychiatry (1986)

CSF homovanillic acid levels showed a significant negative correlation with ventricle-brain ratios (VBRs) in a group of drug-free chronic schizophrenic male veterans, while CSF 5-hydroxyindoleacetic acid levels showed a similar, nearly significant trend. The response of plasma human growth hormone to 0.75 mg of apomorphine also demonstrated a significant negative correlation with VBR in this group, but other measures of central neurotransmitter activity were unrelated to ventricular size.
Part II. Clinical Evaluation of a Serologically Active Non-Saponifiable Fraction of Liver of Cancer-Bearing Patients&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: George C. Hall, M. D., Andrew H. Dowdy, M. D., Harry S. Penn, M. D., Albert W. Bellamy, Ph. D.
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Part II. Clinical Evaluation of a Serologically Active Non-Saponifiable Fraction of Liver of Cancer-Bearing Patients Get access George C. Hall, M. D., George C. Hall, M. D. Director Professor of Zoology, University of California at Los Angeles, Los Angeles, Calif.Tumor Control Center, Veterans Administration and Assistant Clinical Professor of Radiology (Oncology), School of Medicine, Search for other works by this author on: Oxford Academic PubMed Google Scholar Andrew H. Dowdy, M. D., Andrew H. Dowdy, M. D. Professor of Zoology, University of California at Los Angeles, Los Angeles, Calif.Professor and Chairman of the Department of Radiology, School of Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar Harry S. Penn, M. D., Harry S. Penn, M. D. Professor of Zoology, University of California at Los Angeles, Los Angeles, Calif.Research Associate, Department of Zoology Search for other works by this author on: Oxford Academic PubMed Google Scholar Albert W. Bellamy, Ph. D. Albert W. Bellamy, Ph. D. Professor of Zoology, University of California at Los Angeles, Los Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1399–1416, https://doi.org/10.1093/jnci/12.6.1399 Published: 01 June 1952 Article history Received: 14 March 1951 Published: 01 June 1952
Insensitivity of Laminin Degradation Directed by Receptor Bound Urokinase to PAI-1 in Cultured Colon Cancer
Authors: J W Schlechte, D D Boyd
Journal: Cancer Communications (1990)

This laboratory recently reported that laminin degradation by cultured colon cancer was plasminogen dependent and reflected the presence of urokinase bound to cell surface receptors. (Schlecte, W.; Murano, G.; Boyd D. Cancer Res., 49:6064-6069; 1989). The present study was undertaken to determine the sensitivity of urokinase receptor directed proteolysis to the type I plasminogen activator inhibitor (PAI-1). Colon cancer cell types, that were highly effective in degrading laminin in vitro, elaborated into their conditioned medium an inhibitor which was indistinguishable from PAI-1 on the basis of its performance in reverse zymography, western blotting, and immunoprecipitation assays. A fraction of this PAI-1 was active, as evidenced by complex formation with the active site of radioactive urokinase. Laminin degradation by the colon cancer cells, however, did not appear to be affected by the endogenous inhibitor, since an antibody to the inhibitor, which blocked urokinase-PAI-1 interactions, had little effect on laminin turnover. Further, addition of exogenous PAI-1, activated by guanidine hydrochloride pretreatment, to the colon cancer cells did not perturb laminin degradation. Because laminin degradation by colonic cells was a function of receptor bound urokinase, presumably immobilized plasminogen activator escaped the neutralizing effect of the inhibitor. These data suggest either a shielding effect of the receptor on the plasminogen activator or a physical separation of activator and inhibitor. Either way, for cultured colon cancer at least, laminin degradation directed by urokinase receptor bound plasminogen activator appeared unaffected by the presence of this inhibitor.
NODULAR GOITER AND THYROID CANCER
Authors: E A Valdina
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Amitriptyline in human breast milk and the nursing infant's serum
Authors: T F Bader, K Newman
Journal: American Journal of Psychiatry (1980)

6. Hollister LE: Clinical Pharmacology of Psychotherapeutic Drugs. New York, Churchill Livingstone, 1978 7. Shader RI, DiMascio A: Psychotropic Drug Side Effects. Baltimore, Williams & Wilkins Co. 1970 8. Biros D, Schiele BC, Ferguson D: A comparison of Melitracen and imipramine, in Treatment of Depressed Patients, Current Therapeutic Research, vol 2. New York, Therapeutic Research Press, 1969, pp 289-295 9. Barker PA, Ashcroft GW, Binns JK: Imipramine in chronic depression. J Ment Sci 106:1447-1451, 1960
Response to memory training and individual differences in verbal intelligence and state anxiety
Authors: J A Yesavage, J Sheikh, E D Tanke, R Hill
Journal: American Journal of Psychiatry (1988)

Prior studies have documented the effectiveness of several types of memory training for the elderly with normal age-related memory losses. Despite these positive results, there is substantial variability of individual response to treatment. The authors describe attributes of individuals most likely to benefit from two types of memory training. They found that for 40 elderly volunteers performance on the WAIS vocabulary subscale correlated with response to a treatment combining mnemonics and verbal elaboration techniques and scores on the Spielberger State-Trait Anxiety Inventory correlated with response to a treatment combining mnemonics and relaxation techniques.
Effects of neuroleptic adjustment on clinical condition and tardive dyskinesia in schizophrenic patients
Authors: M H Branchey, L B Branchey, M A Richardson
Journal: American Journal of Psychiatry (1981)

The authors decreased neuroleptic medication in 21 chronic schizophrenic patients in an attempt to minimize the risks of tardive dyskinesia. Level of psychopathology and severity of dyskinetic symptoms were monitored while the neuroleptic was gradually decreased over 3 months and then discontinued. Only 1 patient relapsed during drug decrease; however, 15 patients relapsed within 6 months after drug withdrawal. After relapse, medication was gradually increased. The doses needed to induce recovery were higher than those which had been sufficient to prevent relapse during gradual drug reduction. Dyskinetic symptoms were not significantly modified during drug reduction but increased significantly after drug discontinuation.
Nontranssexual Men Who Seek Sex Reassignment
Authors: Lawrence E. Newman, Robert J. Stoller
Journal: American Journal of Psychiatry (1974)

Men other than those with true psychosexual inversion (e.g., transvestites, homosexuals, and schizophrenics) may seek sex-reassignment surgery for a variety of reasons related to individual psychopathology. Unlike transsexuals, however, these patients have a deep underlying attachment to their masculinity, and their desire for sex change is transitory. Thus it is important that the psychiatrist allow sufficient time to evaluate the stability of the patient's desire for surgery.
CASE REPORTS
Authors: JAMES E. RAMIN, HENRY VEIT
Journal: American Journal of Psychiatry (1953)

1. As Kalinowsky and Hoch indicate, fractures of the scapula are rare, but they do occur. 2. A loud snapping noise, such as the "snapping of a stepped-on bent twig" is considered a diagnostic sign for scapular fractures. 3. As a variety of complications do occur, though rarely, it is to be recommended that doctors doing electroshock treatment receive special instructions in regard to the electroshock unit and the possible complications.