tbuckley/cabot-search huggingface dataset:
Abstract 2067: Tumor cell survival under microenvironmental stress: Hypoxia and/or low glucose upregulate poline oxidase
Authors: Wei Liu, Anit Sharma, James M. Phang
Journal: Cancer Research (2011)

Abstract Proline is a stress substrate which can be readily released from collagen in extracelluar matrix (ECM) initiated by matrix metalloproteinases accompanying tumor progression and invasion. Proline oxidase (POX) can metabolize proline to generate reactive oxygen species (ROS) for inducing apoptosis or autophagy; it also is a source of energy (ATP) under metabolic stress. However, the contribution of proline metabolism to tumorigenesis under concurrent hypoxia and low-glucose in the tumor microenvironment, has not been explored. In the present study, we showed that hypoxia and low glucose induced POX expression in HT29 colorectal cancer cells. The combination of low-glucose and hypoxia had additive effects on POX expression. Knockdown of HIF-1α, an important mediator of the hypoxic response, did not alter POX expression. Instead, inhibition of the activation of AMPK, the celluar energy sensor, by its antagonist (Compound C) blocked the upregulation of POX under conditions of either hypoxia or low glucose. Functional studies showed POX was consistently responsible for the maintenance of cell growth under hypoxia, low-glucose or with the combination of both. However, ATP and ROS assays showed that ATP production from POX was favored under low-glucose condition with or without hypoxia, whereas POX preferred ROS production with hypoxia. POX knockdown partially decreased hypoxia-induced prosurvival autophagy, which was also decreased by the antioxidant, N-acetylcysteine. Taken together, these results suggest that the induction of proline metabolism with hypoxia and/or low-glucose contributes an important mechanism by which tumor cells switch to a survival mode. These findings offer new insights into our understanding of energy metabolism in tumor cells beyond the well-recognized Warburg effect of aerobic glycolysis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2067. doi:10.1158/1538-7445.AM2011-2067
THE IMPACT OF ATRIAL FIBRILLATION ON ENDOTHELIAL DYSFUNCTION
Authors: Gerasimos Siasos, Savvas Mazaris, Konstantinos Zisimos, Evangelos Oikonomou, Eleni Kokkou, Theodosia Konsola, Konstantinos Mourouzis, Manolis Vavuranakis, Theodoros Zografos, Marina Zaromitidou, George Lazaros, Christine Chrysohoou, Athanasios Papavassiliou, Christodoulos I Stefanadis, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2015)
SAT0428 A Randomized Single-Blind Controlled Clinical Trial of Phonophoresis for the Treatment of Chronic Neck Pain
Authors: D. Durmus, G. Alayli, A. Bilgici, O. Kuru
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Chronic neck pain (CNP) is a severe health problem in the general population due to its high prevalence and frequent association with disability. There are various approaches involved in the treatment of the CNP. <h3>Objectives</h3> The aim of this trial was to investigate and compare the effects of phonophoresis (PP), placebo PP and exercise therapies on pain, range of motion of neck, disability, sleep quality, and depression in the patients with chronic neck pain (CNP). <h3>Methods</h3> This is a randomized, single-blind placebo controlled study. A total of 61 patients with definite CNP were included in this study. The patients were randomized into three groups. Group 1 (<i>n =</i> 21) received PP with capsaicin treatment and exercises. Group 2 (<i>n =</i> 20) received placebo PP with capsaicin and exercises. Group 3 (<i>n =</i> 20) was given only exercises. All of the programs were performed 3 days a week, for 6 weeks. The pain (visual analog scale, VAS), disability (The neck pain disability index, NPDI), range of motion of neck, depression (Beck Depression Inventory scores, BDI), and sleep quality (Pittsburgh Sleep Quality Index, PSQI) of all participants were evaluated. Measurements were taken before and after treatment. <h3>Results</h3> All of the groups showed statistically significant improvements in pain, range of motion of neck, disability, sleep quality, and depression. The intergroup comparison showed significant differences in pain, range of motion of neck, and disability among three groups except depression and sleep quality. These differences were statistically significant in groups 1 and 2 compared with the group 3. The intergroup comparison showed significant difference in pain, range of motion of neck, disability, between groups 1 and 2. This difference was statistically significant in the group 1. <h3>Conclusions</h3> We observed that PP treatment was effective in the treatment of patients with CNP. A combination of PP with exercises can be used to obtain optimal clinical results. <h3>Disclosure of Interest</h3> None Declared
Differential Clubbing and Cyanosis
Authors: T M Anoop, K C George
Journal: New England Journal of Medicine (2011)

A 30-year-old woman with known congenital heart disease presented to our clinic with a 1-year history of fatigue, hemoptysis, and progressive exertional dyspnea. On examination, the toes had mild cyanosis and marked clubbing, but the fingers had subtle clubbing only. She was noted to have a left parasternal heave, a palpable second heart sound, and a systolic ejection murmur audible in the pulmonic area. Contrast echocardiography showed right atrial and right ventricular dilatation, an elevated mean pulmonary-artery pressure of 68 mm Hg, and bidirectional flow through a patent ductus arteriosus. In Eisenmenger's syndrome, a long-standing systemic-to-pulmonary circulatory shunt results in . . .
Gastroentero anastomose par technique NOTES pure et apposition tissulaire par prothèse métallique couverte courte « diabolo »: une étude prospective expérimentale sur modèle porcin
Authors: G Vanbiervliet, R Garcès, JM Gonzalez, EA Bonin, MC Saint Paul, E Garnier, S Berdah, M Barthet
Journal: Endoscopy (2014)

Plusieurs travaux ont montré la faisabilité de la gastro entéro anastomose par technique N.O.T.E.S exclusive sur modèle porcin vivant. Mais la courbe d'apprentissage et la spécificité du matériel en limite la diffusion. Le but de cette étude expérimentale est de déterminer la faisabilité et la reproductibilité d'une nouvelle technique d'anastomose gastro jéjunale in vivo chez le cochon en technique N.O.T.E.S exclusive avec usage de prothèse métallique couverte.
Birth of a Normal Girl after in Vitro Fertilization and Preimplantation Diagnostic Testing for Cystic Fibrosis
Authors: Alan H. Handyside, John G. Lesko, Juan J. Tarín, Robert M.L. Winston, Mark R. Hughes
Journal: New England Journal of Medicine (1992)

Cystic fibrosis is a common, severe autosomal recessive disease caused in a majority of cases by a three-nucleotide deletion (ΔF508) in the cystic fibrosis transmembrane regulator gene. Current methods of prenatal diagnosis involve chorionic-villus sampling or amniocentesis. In vitro fertilization and diagnosis during embryonic development before implantation would allow only unaffected embryos to be selected for transfer to the uterus, thereby avoiding the need to terminate a pregnancy.
DRENAJE DE LA VESÍCULA BILIAR GUIADO POR ULTRASONOGRAFÍA ENDOSCÓPICA (USE) MEDIANTE PRÓTESIS DE APOSICIÓN LUMINAL (PAL) COMO TRATAMIENTO PALIATIVO DEFINITIVO: RESULTADOS A LARGO PLAZO
Authors: I Peñas, R Sánchez, F Santos, V Busto, A Loza, R Amo, P Fernández, MA Vallecillo, C De La Serna, M Perez-Miranda
Journal: Endoscopy (2014)

Introducción: El drenaje de la vesícula biliar guiado por USE (DVB-USE) es comparable en pacientes de alto riesgo a la colecistostomía percutánea a corto plazo (Jang, Gastroenterology 2012). Las PAL podrían añadir eficacia al DVB-USE, pero los seguimientos son limitados (De la Serna-Higuera, GI Endosc 2013).
P4-19-06: Ghrelin Expression Is Associated with Favorable Outcome in Male Breast Cancer.
Authors: M Grönberg, C Nilsson, I Johansson, I Hedenfalk, ET Janson, M-L Fjällskog
Journal: Cancer Research (2011)

Abstract Background: Expression of the peptide hormones ghrelin and obestatin has previously been demonstrated in normal breast as well as in breast cancer. Interestingly, ghrelin expression has been shown to be associated with longer survival in female patients suffering from invasive breast cancer. However, the clinical implications of the expression of these peptides in male breast cancer are unclear. The aim of this study was to further investigate the role and potential clinical value of these peptides in male breast cancer. Methods: A tissue microarray containing male breast cancer specimens from 197 patients was immunostained with antibodies directed towards the peptides. The expression of the peptides was evaluated and correlated to previously known prognostic factors in breast cancer and to the outcome. Cox regression analysis was used to assess whether these markers may predict survival of male breast cancer patients. Results: Immunoreactivity for ghrelin and obestatin was observed in 81% and 87% of the cases, respectively. No strong correlations were found between ghrelin or obestatin expression and other known prognostic factors. Only ghrelin expression was significantly correlated to breast cancer-specific survival (HR=0.37−0.39, p=0.01−0.03) in both uni- and multivariate analyses. Reproducibility between the two readers was good to very good for both stainings with kappa values of 0.65−0.89. Conclusions: Male breast cancer patients with tumors expressing ghrelin had 3 times lower risk for breast cancer death than those lacking ghrelin expression. Ghrelin expression is easily assessable with good reproducibility using immunohistochemistry. Further studies are needed to establish the clinical significance of ghrelin as a biomarker in breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-19-06.
Sodium-Potassium-ATPase Activity Is Influenced by Ethnic Origin and Not by Obesity
Authors: Ernest Beutler, Wanda Kuhl, Peter Sacks
Journal: New England Journal of Medicine (1983)

Previous investigations have suggested that red-cell ouabain binding (an indirect measure of sodium-potassium-ATPase activity) is lower in severely obese patients than in normal controls. We now confirm that ouabain binding measures sodium-potassium-ATPase activity, and we demonstrate that the level of this activity is genetically determined. The activity of this enzyme differs in various ethnic and racial groups, relatively high levels being encountered in non-Jewish white subjects, particularly those with some Scandinavian ancestry. On the other hand, black, Asian, and Jewish white subjects have lower sodium-potassium-ATPase activity. In contrast, no difference was found in red-cell sodium-potassium-ATPase activity between severely obese and normal persons, nor could we confirm a putative effect of food intake on the level of the red-cell enzyme. We suggest that in most earlier studies in which differences were found between normal and severely obese persons, those differences could have been due to differences in the ethnic origins of the obese and control populations. (N Engl J Med 1983; 309:756–60.)
¿LA INSUFLACIÓN CON CO2 PUEDE REDUCIR LA NECESIDAD DE SEDACIÓN EN COLONOSCOPIA? ESTUDIO DE COHORTES PROSPECTIVO EN PACIENTES AMBULATORIOS
Authors: B Crespo Suárez, A Salazar Laya, T Vázquez Rey, L García Dieguez, N Pin Vieito, I Couto Wörner, R Pardeiro Pértega, L Vázquez Pérez-Coleman, M Blanco Rodriguez, PA Alonso Aguirre
Journal: Endoscopy (2011)

Introducción: La sedación durante la colonoscopia mejora la calidad del examen y su satisfacción aunque su realización no está exenta de riesgos. Múltiples estudios han comunicado una reducción significativa de las molestias abdominales provocadas durante la colonoscopia gracias a la insuflación con CO2 frente al aire.
AB1067 Golimumab Utilization Patterns and Refill Adherence in Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis
Authors: L. Ellis, S. Bolge, P. Rice
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Golimumab (GLM) is a subcutaneous anti-TNF medication indicated once-monthly for patients with rheumatoid arthritis (RA), psoriatic arthritis (PSA), and ankylosing spondylitis (AS). Information about real-world utilization patterns is important for rheumatologists understanding about how patients take their medication. <h3>Objectives</h3> This study reports real-world utilization patterns observed for RA, PSA, and AS patients treated with GLM. <h3>Methods</h3> Patients with an ICD-9 code for RA, PSA, or AS receiving ≥2 fills of GLM as their first biologic medication (bionaive) or most recent biologic medication (bio-experienced) were identified between 1/1/2008 and 12/31/2010 in a large healthcare claims dataset (Truven Health). Patient characteristics and refill patterns were summarized using descriptive statistics. The proportion of adherent refills was calculated as the number of refills occurring between 21and 38 days from a previous fill divided by the total refill intervals. <h3>Results</h3> A total of 1,515 patients with ≥2 GLM fills and a diagnosis of RA (n=1,036), PSA (n=325) or AS (n=154) were identified in the database. Median age was: RA 52 years; PsA 50 years; AS 47 years. The majority were bio-experienced (RA 72%; PsA 79%; AS 79%). A total of 13,738 GLM refills were observed (RA 9,398; PsA 2,961; AS 1,369). The number of refills per patient ranged from 2 to 34 with a mean (SD) of 10.1 (7.25) and median of 8. The mean (SD) interval for all refills was 34.8±13.0 days; median was 31 days. Median refill interval for RA, PsA and AS was 31 days in bio-experienced subgroups and 32 days for bionaive subgroups. The proportion of adherent refills overall was 78%; (RA 79%; PSA 76%; AS 78%). The proportion of adherent refills appeared similar for bionaive and bioexperienced patients except in the AS group (bionaive 73.8%; bioexperienced 79.3%). <h3>Conclusions</h3> This retrospective observational study confirms earlier findings that GLM is utilized largely in patients who have used other biologic medications. A high proportion of GLM-treated patients were adherent to refilling medication and median refill intervals occurred as recommended in the GLM prescribing information. <h3>Disclosure of Interest</h3> L. Ellis Employee of: Janssen Scientific Affairs, LLC, S. Bolge Employee of: Janssen Scientific Affairs, LLC, P. Rice Consultant for: Janssen Scientific Affairs, LLC <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3027
AB0491 Treatment of Incident Sle, Results from the Finnish Nationwide Register 2000-2007
Authors: P. Elfving, K. Puolakka, H. Kautiainen, L. Virta, T. Pohjolainen, O. Kaipiainen-Seppänen
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> To examine the first-year treatment of incident SLE. <h3>Methods</h3> The Finnish nationwide register data on special reimbursement decisions for SLE medication costs was screened to identify the inception cohort of adult SLE patient years 2000-2007. The cohort was shared in 2-year time periods according to index date. The patients were linked to prescription register, which includes drugs purchased from pharmacies. Both registries are maintained by the Social Insurance Institution. The first-year treatment of incident SLE was evaluated. <h3>Results</h3> A total of 566 subjects (87% females) were included in the incident cohort. Five percent of patients had not used any medicine and 80% had used some disease modifying anti-rheumatic drug (DMARD) during the first- year treatment. Prescriptions of mycophenolate mofetil as an initial treatment increased significantly throughout the time periods (2000-01, 2002-03, 2004-05 and 2006-07). Since year 2004 orally taken cyclophosphamide was not used in the first-year treatment of SLE. <h3>Conclusions</h3> Mycophenolate mofetil had a significant increasing trend in treatment of incident SLE during the study time. During the follow-up use of hydroxychloroquine and disease modifying anti-rheumatic drugs (DMARDs) was stable. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3086
Case 28-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, James M. Becker, Carolyn C. Compton
Journal: New England Journal of Medicine (1990)

Presentation of CaseA 72-year-old woman was admitted to the hospital because of severe abdominal pain.The patient was well and active until five days earlier, when there was the onset of severe band-like pain about the level of the umbilicus, without radiation elsewhere, accompanied by a sensation of abdominal bloating; the pain was constant and was not affected by position or antacids but increased in severity about half an hour after meals. The patient's stools became soft, with a single episode of hematochezia; after two or three days she stopped passing stools. Several days before admission the pain became . . .
P91CB2 receptor influences adaptation of cardiomyocytes to hypoxia and their survival during inflammatory stress in vitro
Authors: JC Heinemann, GD Duerr, O Dewald
Journal: Cardiovascular Research (2014)

Purpose: The endocannabinoid system and cannabinoid receptor CB2 have been associated with modulation of inflammatory response and myocardial adaptation after ischemic injury. We recently demonstrated activation of endocannabinoid system and CB2 receptor being associated with inflammatory response in patients with myocardial hypertrophy due to aortic stenosis. Therefore we evaluated CB2 effects on cardiomyocytes and macrophages in cell culture under stress conditions in vitro. Methods: Murine embryonic (eCM) and adult (CM) cardiomyocytes as well as murine macrophages (MO) were derived from wildtype- (WT) and CB2-deficient (CNR2(-/-)) mice and cultured under normoxia and hypoxic conditions (2% O2). We investigated each cell line in separate cultures as well as in co-culture of MOs and eCMs in order to analyse the impact of inflammation on eCM survival. Immunohistochemical and molecular analysis (qPCR) were performed. MO proliferation was assessed using CFSE, migration in Boyden chamber and phagocytosis activity with FITC-dextrane uptake. Results: We found a significant induction of CB2 receptor mRNA and protein in both murine cardiomyocytes (eCMs & CMs) and MOs in vitro following the cultivation under hypoxic conditions and/or stimulation with pro-inflammatory interferon g. CNR2(-/-)-CMs showed a significantly higher level of conglobated, non-vital CMs after incubation under hypoxic conditions when compared to respective WT-CMs. CNR2(-/-)-eCMs showed a significantly less induction of cardioprotective superoxide dismutase 3 under hypoxic conditions. We observed a prolonged proliferation, a significantly stronger migration, but less phagocytosis potential in CNR2(-/-)-MOs than in corresponding WT-cultures. Co-culture revealed a significantly higher loss of eCMs and an induction of their apoptosis after cultivation with CNR2(-/-)-MOs due to their TNF-a and caspase-3 induction. Conclusions: CB2 receptor seems to provide cardioprotection under hypoxia through a complex mechanism including induction of superoxide dismutase 3 in cardiomyocytes and modulation of macrophage function via release of pro-apoptotic factors, thus contributing to survival of cardiomyocytes.
Is It a Record?
Authors: E. R. C. Walker
Journal: BMJ (1969)

premises, but had undertaken several modem hospital, university, and school contracts.The building consists-of panelbdard on a concrete base covered by tiles with pebbledash, which enhances the appearance, and is treated against damp and fungus.The roof is to B.S.I. specification and has metal joints and a gfadient to ensure correct draining
Robin Hood Caught in Wonderland
Authors: David Morland, Valérie Wolff, Jean-Louis Dietemann, Christian Marescaux, Izzie Jacques Namer
Journal: Clinical Nuclear Medicine (2013)

We present the case of a 53-year-old woman presenting several episodes of body image distortions, ground deformation illusions, and problems assessing distance in the orthostatic position corresponding to the Alice in Wonderland syndrome. No symptoms were reported when sitting or lying down. She had uncontrolled hypertension, hyperglycemia, hypercholesterolemia, and a history of head trauma. Her condition had been diagnosed with left internal carotid artery dissection 2 years earlier. Brain SPECT with 99mTc-ECD performed after IV injection of the radiotracer in supine and in standing positions showed hypoperfusion in the healthy contralateral frontoparietal operculum (Robin Hood syndrome), deteriorating when standing up.
Ixmyelocel-T for patients with ischaemic heart failure: a prospective randomised double-blind trial
Authors: Amit N Patel, Timothy D Henry, Arshed A Quyyumi, Gary L Schaer, R David Anderson, Catalin Toma, Cara East, Ann E Remmers, James Goodrich, Akshay S Desai, David Recker, Anthony DeMaria
Journal: The Lancet (2016)
Myotonia of the Tongue
Authors: Zhan Jun Wang, Xu Sheng Huang
Journal: New England Journal of Medicine (2011)

A 27-year-old woman presented with a 1-year history of progressive weakness and grip myotonia in both hands. There was no family history of any similar condition and no personal history of cataracts. Physical examination revealed weakness of the muscles of the face, neck, shoulder girdle, and hands. Myotonia was elicited with percussion of the tongue (see video), finger extensors, and thenar eminence. Sensation, coordination, and cognition were normal. Electromyography showed myotonic discharges and low-amplitude motor-unit potentials of short duration, indicating myopathy. Serum levels of electrolytes and thyrotropin were normal; the level of serum creatine kinase was mildly elevated at 245 . . .
PREDICTORS FOR ADVERSE OUTCOMES AFTER TRICUSPID VALVE SURGERY
Authors: Luis D. Meggo Quiroz, Luis Bowen, Olufisayo Otusanya, Okechukwu Mgbemena, Sameer Ather, Himanshu Aggarwal, Navkaranbir Bajaj, Mustafa Ahmed, Mark Sasse, Massoud Leesar, Oluseun Alli
Journal: Journal of the American College of Cardiology (2015)