tbuckley/cabot-search huggingface dataset:
Abstract 1936: Notch signaling is switched off and displays properties of a tumor suppressor in Ewing's sarcoma
Authors: Idriss M. Bennani-Baiti, Dave N.T. Aryee, Jozef Ban, Maximilain Kauer, Karin Mühlbacher, Isidro Machado, Gabriele Amann, Antonio Llombart-Bosch, Heinrich Kovar
Journal: Cancer Research (2011)

Abstract Notch can act as an oncogene or as a tumor suppressor and thus can either promote or inhibit tumor cell growth. To establish Notch status in Ewing's sarcoma family of tumors (ESFT), we investigated the Notch pathway by gene expression profiling meta-analysis or immunohistochemistry in samples obtained from 96 and 24 ESFT patients, respectively. We find that although Notch receptors were highly expressed, Notch did not appear to be active as evidenced by the absence of Notch receptors in cell nuclei. High expression of the Notch effector HES1 transcription factor, usually used as a surrogate marker for active Notch, was also restricted to outside of the nucleus in the majority of tumors, and analysis of HES1 gene targets indicated HES1 to be transcriptionally inactive. Neither forced activation nor pharmacological or genetic blocking of Notch affected HES1 expression in ESFT cells, indicating HES1 expression to be uncoupled from the Notch pathway. Additional functional studies in ESFT cell lines confirmed Notch to be switched off. Finally, unlike experiments in which HES1 expression was modulated, experimental activation of Notch in ESFT cell lines via several means blocked cell proliferation. These indicate that HES1 is uncoupled from Notch in ESFT, that EWS-FLI1-mediated inhibition of Notch contributes to ESFT aggressive cell growth, and supports a role for Notch in ESFT tumor suppression, at least partly through the Notch effector HEY1. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1936. doi:10.1158/1538-7445.AM2011-1936
Cancer Researcher Chosen for Space Mission
Authors: Michael E. Newman
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Cancer Researcher Chosen for Space Mission Get access Michael E. Newman Michael E. Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 14, 17 July 1991, Page 987, https://doi.org/10.1093/jnci/83.14.987 Published: 17 July 1991
Bilateral Obstructive Uropathy and Anuria From a Single Ureteric Calculus
Authors: IAN D. KIRKWOOD, KIRK FREY, MELVYN T. KOROBKIN
Journal: Clinical Nuclear Medicine (1998)

A woman presented with acute bilateral loin pain and anuria. An unenhanced spiral CT revealed bilateral renal obstruction and a calculus within the left ureter. After the insertion of a stent into the left ureter, a diuretic renal scan and a contrast-enhanced CT scan showed a calculus at the anastomosis of a right transureteroureterostomy and relief of the obstruction. This case illustrates bilateral obstructive uropathy caused by a solitary ureteric calculus.
Ga-67 SPECT To Detect Endocarditis After Replacement of an Aortic Valve
Authors: FRANCISCO JOSÉ PENA, IGNACIO BANZO, REMEDIOS QUIRCE, NICOLÁS KURT VALLINA, ANA HERNÁNDEZ, CONSTANTINO GUEDE, JOSÉ MANUEL CARRIL
Journal: Clinical Nuclear Medicine (2002)

Ga-67 SPECT was crucial in making the diagnosis of infectious endocarditis in a 28-year-old man with a history of aortic valve replacement who was referred to the nuclear medicine service because of persistent fever. In the planar left anterior oblique view, an area of slight, diffuse activity was noted. The shape and site of the infectious focus were well defined by Ga-67 SPECT. After Ga-67 imaging, results of a computed tomographic (CT) scan were negative and the patient was treated with antibiotics and discharged from the hospital after showing clinical improvement. However, the fever returned and he was readmitted. A second Ga-67 SPECT was also positive, but a spiral CT scan showed only minor inflammatory changes. Finally, transesophageal ultrasonographic images suggested vegetation on the prosthetic valve. Cultures of the graft and the valve were obtained surgically and showed staphylococcal endocarditis. Exaggerated confidence in negative CT scan results led to unnecessarily delayed surgical treatment of the infection. Ga-67 SPECT was a powerful noninvasive tool in the diagnosis of infectious complications after prosthetic valve surgery.
THU0328 The Efficacy of Classical Indian Yoga in the Treatment of Fibromyalgia: A Randomized Controlled Trial
Authors: V. Trivedi, P. Mishra
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Fibromyalgia (FM) is a complex musculoskeletal disorder treated with multidisciplinary therapies. It is manifested by widespread musculoskeletal pain, functional disability, sleep disturbances and poor quality of life. Classical Indian Yoga is an ancient life style healing technique which has an integrated mind-body approach to enhance both physical and mental health, thus having a positive impact in treatment of FM. <h3>Objectives</h3> To study the role of Classical Indian Yoga as an integrated mind-body healing approach in the comprehensive treatment of fibromyalgia. <h3>Methods</h3> This study incorporated a 6 months, single-blind, randomized trial of Classical Indian Yoga (50 patients) versus attention control group (stretching and wellness education) of 50 patients for Fibromyalgia. The classical Yoga involved 60-minute group sessions thrice-weekly. The primary outcome measure was change in the FM Impact Questionnaire (FIQ) score at 1 year. Secondary outcome measures were tender point count, patient and physician global assessments, sleep quality (PSQI), 10-minute walk, timed chair stand, grip strength, depression and quality of life. These outcome measures were repeated at 1 year to test durability of response. Both groups were compared using an intent-to-treat analysis. <h3>Results</h3> Mean age of 100 patients was 55 years (SD 11), disease duration 10 years (SD 7) and BMI 30 kg/m<sup>2</sup> (SD 8), 80 patients were females. Patients baseline expectations of benefit from an exercise intervention were similar: Classical Yoga =4.1 and the controls=4.3. After 6 months patients in the classical Yoga group had a significantly greater improvement in FIQ score: between-group change -20, 95% CI (-24.0 to -8.8); P=0.0005). The Yoga group patients also had significant improvement in secondary outcome measures: reduction in pain scale (VAS), improved patient global assessment, physical function, depression, and health status. After 1 year patients compliant with the classical Yoga had sustained and durable benefits in FIQ score quality of sleep and quality of life. The two groups did not differ in medication usage. No adverse events were noted. <h3>Conclusions</h3> Classical Indian Yoga appears to be highly effective in the management of FM having a positive impact on physical, psychological and social aspects of FM. Yoga can be used as a useful adjunctive treatment in the multidisciplinary treatment of this complex disorder. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1020
SP0176 Management of Primary Care for People with Knee Osteoarthritis: The Beep Study (Best Evidence for Exercise in Knee Pain)
Authors: N. E. Foster
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Nearly all available international guidelines for the management of knee osteoarthritis recommend exercise as a core treatment, ideal for primary care delivery, with effect sizes in the region of 0.3 to 0.4 (moderate effects). This presentation will briefly review best evidence for exercise including recent primary care randomised trials that highlight the benefits of exercise on pain, function and proportions of treatment responders. In addition data on current practice will be presented that highlights the ‘know-do’ gap between best evidence and current primary care management of patients. These data highlight the challenges in supporting evidence-based exercise practice and provide the underpinning rationale for a current large trial, the BEEP study (Best Evidence for Exercise in knee Pain) in the UK. The objective of the BEEP study is to test ways to improve outcomes for patients with knee osteoarthritis from exercise and physical activity, helping people find the right exercise routine and maintain it over time. BEEP is a multicentre randomised controlled trial, funded by the National Institute for Health Research (NIHR) involving adults aged 45 years and over in primary care with a clinical diagnosis of knee osteoarthritis. 526 patients who are eligible and consent to take part are randomised to receive 1 of 3 exercise based interventions delivered by physiotherapists, who have each participated in a BEEP study training programme: - UK usual care: up to 4 treatment sessions over 12 weeks - Individualised, supervised and progressed exercise: between 6 to 8 treatment sessions over 12 weeks and focused on lower limb strengthening, stretching and balance - Targeted exercise adherence: 4 treatment sessions within 12 weeks, plus between 4 to 6 additional contacts from week 12 to month 6, focused on supporting patients to make the transition from lower limb exercise to general physical activity engagement and maintenance. All patients are followed up at 3, 6, 9, 18 and 36 months, to compare the clinical and cost-effectiveness of efforts to optimise exercise care for people with knee osteoarthritis. The study completed recruitment in 2012 and is in follow-up. This presentation will provide a key example of testing approaches to optimise primary care for patients with knee osteoarthritis. <h3>Acknowledgements</h3> NE Foster is supported through an NIHR Research Professorship. This abstract presents independent research funded by the National Institute for Health Research (NIHR) under its Programme Grants for Applied Research Programme (Grant Reference Number RP-PG-0407-10386). The views expressed are those of the author and not necessarily those of the NHS, the NIHR or the Department of Health. <h3>Disclosure of Interest</h3> None Declared
PLASMA ENDOTHELIN-1 INDEPENDENTLY PREDICTS 180-DAY MORTALITY IN ACUTE HEART FAILURE: AN ASCEND-HF SUB-STUDY
Authors: Antonio Perez, Justin Grodin, Adrian Hernandez, Javed Butler, Marco Metra, G. Michael Felker, Adriaan A. Voors, John McMurray, Paul Armstrong, Robert Califf, Randall Starling, Christopher O’Connor, Wai Hong Tang
Journal: Journal of the American College of Cardiology (2015)
Acute Renal Insufficiency Due to Lower-Nephron Nephrosis
Authors: Maurice B. Strauss
Journal: New England Journal of Medicine (1948)

ACUTE renal insufficiency due to the disorder now known as lower-nephron nephrosis1 or hemoglobinuric nephrosis2 occurs in association with a large variety of conditions, including intravascular hemolysis associated with transfusion reactions,3 4 5 6 7 blackwater fever,8 quinine sensitivity9 and transurethral prostatectomy,10 , 11 as well as in the crush syndrome,12 13 14 15 16 17 18 19 20 21 22 23 nontraumatic muscle ischemia,24 electrical injury to muscle,25 heat stroke,26 ureteroplacental damage,27 , 28 after abortion,29 alkalosis from excessive vomiting,30 thermal burns,31 , 32 sulfonamide sensitivity 33 34 35 36 and from various poisons of diverse origin,1 including the most common offender, carbon tetrachloride.37 38 39 40 41 42 43 44 45 46 47 48 The purpose of this communication is to present certain data pertinent to this syndrome and to suggest that treatment based . . .
Apparent Relative Hypermetabolism of Selective Brain Areas in Huntington Disease and Importance of Reference Region for Analysis
Authors: Su Jin Lee, Won Yong Lee, Yu Kyeong Kim, Young-Sil An, Jin Whan Cho, Joon Young Choi, Byung-Tae Kim, Kyung-Han Lee
Journal: Clinical Nuclear Medicine (2012)

We investigated the pattern of reduced and increased metabolism in symptomatic Huntington chorea (HD) patients and assessed the influence of intensity normalization method.FDG brain PET was performed in 11 manifest HD patients and 11 age-matched controls. Images underwent statistical parametric mapping analysis after global normalization or with white matter or pons as reference region. Region of interest analysis of FDG uptake ratios was also performed using total region or white matter as reference. Correlation between regional uptake ratios to that of the caudate was evaluated by linear regression analysis.Although statistical parametric mapping analysis identified striatal hypometabolism and thalamic hypermetabolism in HD patients with all methods, substantially different FDG uptake patterns were shown depending on the method of intensity normalization. Global normalization displayed large areas of relative normalized hypermetabolism across the cerebral cortex and cerebellum. With white matter as reference, relative normalized hypermetabolism was observed in the thalamus and a much more limited area of the cortex. With pons as reference, relative normalized hypermetabolism was largely confined to the thalamus and a small area of the cerebellum.These results demonstrate apparent relative normalized hypermetabolism in selective brain regions in manifest HD patients. Furthermore, the choice of reference region for intensity normalization is critical for accurate monitoring of this metabolic change with FDG PET.
Low-Grade Gliomas: Answering One Question in a Myriad of New Questions
Authors: John M. Buatti, Sanford L. Meeks, Timothy C. Ryken, Thomas L. Carlisle
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.9.2223 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11980992 Low-Grade Gliomas: Answering One Question in a Myriad of New Questions John M. BuattixJohn M. BuattiSearch for articles by this author , Sanford L. MeeksxSanford L. MeeksSearch for articles by this author , Timothy C. RykenxTimothy C. RykenSearch for articles by this author , Thomas L. CarlislexThomas L. CarlisleSearch for articles by this author Show More University of Iowa College of Medicine, Iowa City, IA https://doi.org/10.1200/JCO.2002.20.9.2223 Full Text PDF Figures and Tables "Low-Grade Gliomas: Answering One Question in a Myriad of New Questions." Journal of Clinical Oncology, 20(9), pp. 2223–2224© 2002 by American Society of Clinical Oncology
TCT-701 A Multidisciplinary, Multimodality, but Minimalist (3M) approach to transfemoral transcatheter aortic valve replacement facilitates safe next day discharge home in high risk patients: 1 year follow up
Authors: David A. Wood, Rohan Poulter, Richard Cook, Dion Stub, Jonathon A. Leipsic, Jian Ye, Anson Cheung, Danny Dvir, Iefan Lim, Mathieu Lempereur, Nigussie Bogale, Imran A. Shiekh, Peter Fahmy, John S. Tan, John Jue, Ken Gin, Jonathan K. Todd, Peggy M. DeJong, Philippe Genereux, Leslie Achtem, David Cohen, Sandra Lauck, Martin Leon, Webb John
Journal: Journal of the American College of Cardiology (2014)
Clinicopathologic Features Predicting HER2 Overexpression in Gastric Cancer
Authors: J.S. Park, S. Lim, H.J. Chon, M.H. Hong, B. Kang, M. Jung, S.Y. Rha, J.-b. Ahn, H.C. Chung, H.S. Kim
Journal: Annals of Oncology (2013)
AB0881 Biologic Disease Modifying Anti-Rheumatic Drug Use in the Treatment of Juvenile Idiopathic Arthritis: Data from the Rheumatic Diseases Portuguese Register, Reuma.Pt
Authors: A.F. Mourão, M.J. Santos, J.A. Melo Gomes, F.M. Martins, F. Ramos, S. Fernandes, M. Salgado, M. Guedes, S. Carvalho, J.A. Costa, C. Duarte, I. Brito, R. Figueira, G. Figueiredo, A.C. Furtado, A. Lopes, M. Oliveira, A. Rodrigues, G. Sequeira, M. Sousa, J.C. Branco, J. Eurico Fonseca, H. Canhão
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The Portuguese Society of Rheumatology developed the Rheumatic Diseases Portuguese Register (Reuma.pt) encompassing also Juvenile Idiopathic Arthritis patients followed by rheumatologists and pediatricians. <h3>Objectives</h3> 1. To obtain an overview of biological agents use in Portuguese children with JIA. 2. To assess the effectiveness and safety of biological therapy at 6 months and 1 year of treatment. <h3>Methods</h3> We retrieved data from Reuma.pt, until December 2013. We collected baseline patient and disease characteristics of patients with JIA who started treatment with biological agents. Follow-up data were analyzed and are presented at 6 months and 1 year. Disease activity was assessed using the number of active joints, ESR and CHAQ. <h3>Results</h3> 812 patients with JIA,227 received biological therapy.The mean age at disease onset of patients treated with biologic DMARDs was 6.9±4.7years and the mean age for starting biological therapy was 16.1±9.4years. The most common JIA categories were polyarticular RF negative (23.3%), polyarticular RF+(17.5%) and extended oligoarticular (16.0%).The median duration of the first biological agent was 5.76years. Most patients were treated with antiTNF as first line (90.3%):etanercept 69.2%,adalimumab 12.8%,infliximab 8.4%. Mean baseline active joint count was 5.1±5.8, decreasing to 1.2±2.4 and 1.0±3.1 after 6 months and 1 year of therapy. Mean ESR was 33.9±25.3 mm/1<sup>sth</sup> and 26.9±23.9 and 19.1±180 after 6 months and 1 year. CHAQ decreased from 0.8±0.7 to 0.4±0.5 and 0.4±0.5 at 6 months and 1 year. 14.1% switched once to other biological therapy (3.08% in the first 6 months,4.4% in the first year), 5.73% switched twice (0.88% in the first 6 months,1.76% in the first year) and 2 patients (0.88%) switched 3 times after the first year of treatment. 14 serious adverse events were reported leading to discontinuation of the treatment, 6 in the first 6 months and 8 in the first year of treatment. There were no reported deaths. The one-year treatment retention with biological agents was 91%. <h3>Conclusions</h3> JIA patients treated with biologics and registered in Reuma.pt showed a good profile of effectiveness and safety at 1 year. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3142
OC-039 Improving Quality In A National Intestinal Failure Unit: Greater Efficiency, Improved Access, Reduced Mortality
Authors: E Donaldson, M Taylor, A Abraham, G Carlson, O Fletcher, V Jacqui, A Teubner, S Lal
Journal: Gut (2014)

<h3>Introduction</h3> In 2010, there was a significant waiting list for admission to the Intestinal Failure Unit (IFU) at Salford, one of two current nationally-accredited centres. There had also been a steady increase in referrals to the IFU (89 patients in 2005; 152 patients in 2012) and the number of established patients requiring home parenteral nutrition (HPN) (135 patients in 2005; 206 patients in 2012). The impact of the long waiting list for these complex patients was that patient deaths occurred in those awaiting admission. Furthermore, the 'Strategic Framework for IF and HPN Services' in England had earlier highlighted the need for services to 'foster equity of access'.<sup>1</sup> The SRFT IFU team therefore conducted a rigorous assessment of its processes in order to improve patient flow and access to the IFU. The primary aim was to reduce inpatient length of stay (LOS) by 10%. <h3>Methods</h3> We employed continuous improvement methodology, utilising the Model for Improvement and running sequential Plan-Do-Study-Act cycles. In addition to the key flow data, such as LOS and referral times, process data were collected, including time to intravenous feeding line insertion, time to radiology studies etc., when looking to streamline specific areas of practice. Data were analysed using statistical process control charts produced using QI Macros (KnowWare International, INC.). Statistically significant shifts were determined 'a priori' according to standard operating principals for special cause variation.<sup>2</sup> <h3>Results</h3> Process improvements yielded a 20.8% reduction in average length of stay on the IFU from 55.7 to 44.1 days and a reduction of 70.7% in the average length of time spent on the waiting list for admission from 65.1 to 19.1 days. These changes were associated with concomitant reduction in 30-day readmission rates from 12.1 to 4.5% and early suggestions of reduced waiting list mortality. The number of inpatient deaths did not increase; indeed, there was a sustained increase in the number of complete discharge episodes between inpatient deaths (mean increase from 13 to 44). <h3>Conclusion</h3> A quality improvement model is an effective means of enhancing the efficiency of a large National centre dealing with complex medical and surgical patients. Improvements in inpatient efficiency can reduce waiting times for admission, thus improving access and reducing waiting list mortality. The improvements in efficiency can be achieved without compromising patient safety. <h3>References</h3> 1 Strategic Framework for Intestinal Failure and Home Parenteral Nutrition Services for Adults in England 2008 2 Langley, G <i>et al</i>. 2009. The improvement guide: a practical approach to enhancing organizational performance. John Wiley &amp; Sons <h3>Disclosure of Interest</h3> None Declared.
Abstract 3448: Synergistic effect of benzo(a)pyrene (BaP) and dietary fat on biotransformation enzymes, DNA adducts and colon tumors in Apc<i>Min</i> mice
Authors: Deacqunita L. Harris, Mary K. Washington, Darryl B. Hood, Lyman J. Roberts, Aramandla Ramesh
Journal: Cancer Research (2010)

Abstract Studies in our laboratory thus far have shown formation of colon tumors in ApcMin mice subsequent to ingestion of fat containing BaP, an environmental carcinogen. These findings have human health relevance in that around 60,000 lives/year are lost to colon cancer in US alone. Diet and environment have been implicated in the development of sporadic colon tumors. Since biotransformation of toxicants is one of the factors that trigger carcinogenesis, the objective of this study was to determine how dietary fat potentiates the development of colon tumors through altered BaP biotransformation, using the ApcMin mouse model. Benzo(a)pyrene was administered to ApcMin mice in unsaturated- (peanut oil) and saturated- (coconut oil) fats at doses of 50 and 100 μg/kg via oral gavage over a 60-day period. Blood, colon and liver were collected at the end of exposure period. The expression of BaP biotransformation enzymes (CYP1A1, CYP1B1 and GST) in liver and colon were assayed at the level of mRNA and activities. Tissue samples were analyzed by reverse phase-HPLC for BaP metabolites, and 32P-postlabeling method for BaP- DNA adducts. BaP exposure through dietary fat altered its biotransformation in a dose-dependent manner, with 100 μg/kg dose group registering an elevated expression of BaP biotransformation enzymes, greater concentration of BaP metabolites, BaP-DNA adducts and more adenomas compared to the 50 μg/kg dose group (p &amp;lt; 0.05). This effect was more pronounced for saturated fat group compared to unsaturated fat group (p &amp;lt; 0.05). These findings establish that saturated fat contributes to sustained induction of BaP biotransformation enzymes and extensive metabolism of this carcinogen. As a consequence, the reactive metabolites such as epoxides and quinones generated in colon bind with DNA, and form adducts resulting in colon tumors in a long term exposure situation (funded by NIH grants S11ES014156, 1F31ES017391-01, 5T32 HL007735-14 and RO3CA130112-01). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3448.
398 VIRAL REPLICATION IN HBV-TRANSGENIC MICE LACKING THE HBsAg SIGNIFICANTLY INDUCES INTERFERON RESPONSES
Authors: C.I. Real, R. Broering, M. Trippler, K. Jahn-Hofmann, L. Ickenstein, M. John, K. Kleinehr, S. Driftmann, T. Kemper, H.-P. Vornlocher, R. Schirmbeck, M. Lu, G. Gerken, J.F. Schlaak
Journal: Journal of Hepatology (2013)