tbuckley/cabot-search huggingface dataset:
Analysis of Recurrence Patterns in Acral Versus Nonacral Melanoma: Should Histologic Subtype Influence Treatment Guidelines?
Authors: Priyanka V. Gumaste, Nathaniel H. Fleming, Ines Silva, Richard L. Shapiro, Russell S. Berman, Judy Zhong, Iman Osman, Jennifer A. Stein
Journal: Journal of the National Comprehensive Cancer Network (2014)

Current surgical treatment of primary melanoma is uniform for all histosubtypes, although certain types of melanoma, such as acral lentiginous melanoma (ALM), have a worse prognosis. No study has explored the effectiveness of standard melanoma treatment guidelines for managing ALM compared with nonacral melanoma (NAM). Study subjects were identified from a prospectively enrolled database of patients with primary melanoma at New York University. Patients with ALM were matched to those with NAM (1:3) by gender and melanoma stage, including substage (ALM, 61; NAM, 183). All patients received standard-of-care treatment. Recurrence and survival outcomes in both cohorts were compared. ALM histologic subtype was an independent negative predictor of recurrence-free survival (hazard ratio [HR], 2.24; P=.001) and melanoma-specific survival (HR, 2.58; P=.001) compared with NAM. Recurrence was significantly more common in patients with ALM than in those with NAM (49% vs 30%; P=.007). For tumors less than 2 mm in thickness, a significantly higher recurrence rate was seen with ALM versus NAM (P=.048). No significant difference was seen in recurrence for tumors greater than 2 mm (P=.12). Notably, the rate of locoregional recurrence was nearly double for ALM compared with NAM (P=.001). The data presented herein reveal a high rate of locoregional failure in ALM compared with NAM when controlling for AJCC stage. These results raise the question of whether ALM may require more aggressive surgical treatment than nonacral cutaneous melanomas of equal thickness, particularly in tumors less than 2 mm thick. Larger multicenter trials are necessary for further conclusions.
Periodic Organic Psychosis Associated with Recurrent Herpes Simplex
Authors: Marshall L. Shearer, Stuart M. Finch
Journal: New England Journal of Medicine (1964)

RECURRENT herpes-simplex encephalitis has A never been proved in human beings although cases suggestive of it have been reported. It has been demonstrated in laboratory animals. This is a report of 17 episodes of an organic psychosis associated with recurrent herpes-simplex labialis.Case ReportA 9-year-old boy was well until June 28, 1959, when he became lethargic and vomited. His father noted 2 small pustules on the right side of the lower lip. On the following day fever, with swelling of the mouth, developed, and lesions appeared on both lips. These were diagnosed as herpes simplex. On July 31 he . . .
Attenuation of Isoproterenol-Mediated Vasodilatation in Blacks
Authors: Chim C. Lang, C. Michael Stein, R. Michael Brown, Robert Deegan, Richard Nelson, Huai B. He, Margaret Wood, Alastair J.J. Wood
Journal: New England Journal of Medicine (1995)

The mechanism of enhanced vascular reactivity in young blacks, which may play a part in the development of hypertension, has not been defined. To determine the contribution of blunted vasodilatation mediated by β2-adrenergic receptors to this phenomenon, we compared forearm blood-flow responses to isoproterenol in young black and white normotensive men.
Decreased <i>SMG7</i> expression associates with lupus-risk variants and elevated antinuclear antibody production
Authors: Yun Deng, Jian Zhao, Daisuke Sakurai, Andrea L Sestak, Vadim Osadchiy, Carl D Langefeld, Kenneth M Kaufman, Jennifer A Kelly, Judith A James, Michelle A Petri, Sang-Cheol Bae, Marta E Alarcón-Riquelme, Graciela S Alarcón, Juan-Manuel Anaya, Lindsey A Criswell, Barry I Freedman, Diane L Kamen, Gary S Gilkeson, Chaim O Jacob, Joan T Merrill, Patrick M Gaffney, Kathy Moser Sivils, Timothy B Niewold, Rosalind Ramsey-Goldman, John D Reveille, R Hal Scofield, Anne M Stevens, Susan A Boackle, Luis M Vilá, I I Woong Sohn, Seung Lee, Deh-Ming Chang, Yeong Wook Song, Timothy J Vyse, John B Harley, Elizabeth E Brown, Jeffrey C Edberg, Robert P Kimberly, Rita M Cantor, Bevra H Hahn, Jennifer M Grossman, Betty P Tsao
Journal: Annals of the Rheumatic Diseases (2016)

Objectives Following up the systemic lupus erythematosus (SLE) genome-wide association studies (GWAS) identification of NMNAT2 at rs2022013, we fine-mapped its 150 kb flanking regions containing NMNAT2 and SMG7 in a 15 292 case–control multi-ancestry population and tested functions of identified variants. Methods We performed genotyping using custom array, imputation by IMPUTE 2.1.2 and allele specific functions using quantitative real-time PCR and luciferase reporter transfections. SLE peripheral blood mononuclear cells (PBMCs) were cultured with small interfering RNAs to measure antinuclear antibody (ANA) and cyto/chemokine levels in supernatants using ELISA. Results We confirmed association at NMNAT2 in European American (EA) and Amerindian/Hispanic ancestries, and identified independent signal at SMG7 tagged by rs2702178 in EA only (p=2.4×10 −8 , OR=1.23 (95% CI 1.14 to 1.32)). In complete linkage disequilibrium with rs2702178, rs2275675 in the promoter region robustly associated with SMG7 mRNA levels in multiple expression quantitative trait locus (eQTL) datasets. Its risk allele was dose-dependently associated with decreased SMG7 mRNA levels in PBMCs of 86 patients with SLE and 119 controls (p=1.1×10 −3 and 6.8×10 −8 , respectively) and conferred reduced transcription activity in transfected HEK-293 (human embryonic kidney cell line) and Raji cells (p=0.0035 and 0.0037, respectively). As a critical component in the nonsense-mediated mRNA decay pathway, SMG7 could regulate autoantigens including ribonucleoprotein (RNP) and Smith (Sm). We showed SMG7 mRNA levels in PBMCs correlated inversely with ANA titres of patients with SLE (r=−0.31, p=0.01), and SMG7 knockdown increased levels of ANA IgG and chemokine (C-C motif) ligand 19 in SLE PBMCs (p=2.0×10 −5 and 2.0×10 −4 , respectively). Conclusion We confirmed NMNAT2 and identified independent SMG7 association with SLE. The inverse relationship between levels of the risk allele-associated SMG7 mRNAs and ANA suggested the novel contribution of mRNA surveillance pathway to SLE pathogenesis.
Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency
Authors: Suk See De Ravin, Xiaolin Wu, Susan Moir, Lela Kardava, Sandra Anaya-O’Brien, Nana Kwatemaa, Patricia Littel, Narda Theobald, Uimook Choi, Ling Su, Martha Marquesen, Dianne Hilligoss, Janet Lee, Clarissa M. Buckner, Kol A. Zarember, Geraldine O’Connor, Daniel McVicar, Douglas Kuhns, Robert E. Throm, Sheng Zhou, Luigi D. Notarangelo, I. Celine Hanson, Mort J. Cowan, Elizabeth Kang, Coleen Hadigan, Michael Meagher, John T. Gray, Brian P. Sorrentino, Harry L. Malech
Journal: Science Translational Medicine (2016)

Lentiviral gene therapy with conditioning achieves humoral reconstitution in older SCID-X1 patients.
Kaposi's sarcoma and the acquired immunodeficiency syndrome: treatment with high and low doses of recombinant leukocyte A interferon.
Authors: F X Real, H F Oettgen, S E Krown
Journal: Journal of Clinical Oncology (1986)

The efficacy of recombinant leukocyte A interferon (rIFN-alpha A [Roferon-A, Hoffman-La Roche, Nutley, NJ]) treatment of Kaposi's sarcoma in patients with acquired immunodeficiency syndrome was evaluated in sequential trials using high doses (36 X 10(6) units) and low doses (3 X 10(6) units) of interferon. A major response was seen in 38% of patients treated at the high dose, with a median response duration of 18 months. At the low dose, the major response rate was 3%; dose escalation to 36 X 10(6) units resulted in an additional major response rate of 17% in low-dose nonresponders, with a median response duration of 10 months. Four of 11 patients who achieved a complete response remain free of disease, whereas all partial responders have shown disease progression. Unacceptable toxicity occurred in 27% of patients initially treated at the high dose and only in 10% of those who had progressive dose escalation up to 36 X 10(6) units. Prior opportunistic infections correlated negatively with therapeutic response, whereas large tumor burden and gastrointestinal involvement did not. Responding patients showed a significantly longer survival and a lower incidence of subsequent opportunistic infections than nonresponders. However, from our study we cannot determine whether rIFN-alpha A has an effect on the natural history of Kaposi's sarcoma in patients with the acquired immunodeficiency syndrome.
Prolonged Treatment of Urinary-Tract Infections with Sulfamethoxypyridazine
Authors: Hans G. Grieble, George Gee Jackson
Journal: New England Journal of Medicine (1958)

THE outstanding role of pyelonephritis in renal pathology is well documented.1 2 3 In a recent series it was found in 21 per cent, or more frequently than all other forms of nephritis together.4 Other reports have emphasized the fact that renal infections commonly escape clinical recognition.5 6 7 8 9 10 These findings are in contrast to the apparent optimism about therapy based on the treatment of bacterial infections with effective antimicrobial agents.A favorable impact of the antibiotic era on the prevalence of pyelonephritis was suggested by autopsy records from this hospital,5 but clinical experience has shown that many patients with chronic Urinary Tract infections . . .
A phase II study of UCN-01 in combination with topotecan in patients with advanced recurrent ovarian cancer: A Princess Margaret Phase II Consortium Trial
Authors: H. W. Hirte
Journal: Journal of Clinical Oncology (2005)

3127 Background: The treatment of platinum-resistant recurrent ovarian cancer remains problematic with low response rates which are generally of short duration. The staurosporine derivate UCN-01 has been shown to potentiate the cytotoxicity of topotecan in preclinical models. To determine whether the clinical efficacy of topotecan, one of the standard agents used platinum-resistant ovarian cancer, could be enhanced, it was combined with the cell cycle inhibitor UCN-01. Methods: This phase II study was designed to evaluate the activity and toxicity profile of topotecan and UCN-01 in recurrent ovarian cancer. Patients were required to have measurable disease, 0–2 previous chemotherapy regimens for recurrent disease and performance status 0–2. Topotecan was administered at the phase II recommended doses of 1 mg/m2 iv on days 1 to 5, and UCN-01 at 70 mg/m2 iv on day 1 of the first cycle, and 35 mg/m2 iv on day 1 of subsequent cycles. Matched tumor biopsies have been obtained on 7 patients, pre-treatment and after the first cycle of therapy. Results: A total of 29 patients have been enrolled in the study, all of whom are evaluable for toxicity and response. Median age was 55 (23–72). All patients had received prior platinum and paclitaxel, median number of previous chemotherapy regimens being 2. The most commonly observed grade 3–4 toxicities were neutropenia (79%), anemia (41%), thrombocytopenia (14%), hyperglycemia (10%), febrile neutropenia (10%) and pain (10%). Patients received a median of 3 cycles (1–11). Three patients achieved a PR (10%), 15 SD (52%), and 9 PD (31%). Conclusions: The study criterion to proceed to stage 2 of the protocol required 4 PRs in the first 19 patients in stage 1. Since only 3 PRs have been achieved in the 29 patients, the combination of topotecan and UCN-01 has been deemed insufficiently active to proceed to stage 2 of the protocol and the study has been closed to further accrual. No significant financial relationships to disclose.
The mind-body dichotomy reified: an illustrative case
Authors: M Schoenberg, M G Miller, C E Schoenberg
Journal: American Journal of Psychiatry (1978)

Cartesian dualism, the splitting of human existence into mind versus body, is at times reified with unfortunate consequences. The authors report a case in which a social policy formulation based on such diagnostic dualism resulted in the denial of health-related facility placement to a patient. They argue that this denial was prejudicial and illogical and that benefits should be related to a functional disability rather than to diagnosis.
Case 5-1994
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Barry W. Levine, Volker Nickeleit
Journal: New England Journal of Medicine (1994)

Presentation of CaseA 34-year-old woman was admitted to the hospital because of a dry cough, exertional dyspnea, and interstitial pulmonary disease.The patient had been well until three months earlier, when she experienced the insidious onset of fatigue and mild exertional dyspnea. An antibiotic was prescribed, with temporary improvement. Two months before entry she began to have mild night sweats and had an intermittent low-grade fever. Two weeks before admission a cough developed, and the dyspnea worsened slightly; a physician prescribed clarithromycin and an inhaler, without improvement. On the day of admission the patient was seen at another hospital, . . .
Abstract # 12286: Contribution of Family History to the Prediction of Atrial Fibrillation Risk
Authors: Steven A Lubitz, Xiaoyan Yin, Joao D Fontes, Jared W Magnani, Michiel Rienstra, Ramachandran S Vasan, Michael J Pencina, Daniel Levy, Martin G Larson, Patrick T Ellinor, Emelia J Benjamin
Journal: Circulation (2010)
Apoptosis in the Failing Human Heart
Authors: Giorgio Olivetti, Rakesh Abbi, Federico Quaini, Jan Kajstura, Wei Cheng, James A. Nitahara, Eugenio Quaini, Carla Di Loreto, Carlo A. Beltrami, Stanislaw Krajewski, John C. Reed, Piero Anversa
Journal: New England Journal of Medicine (1997)

Loss of myocytes is an important mechanism in the development of cardiac failure of either ischemic or nonischemic origin. However, whether programmed cell death (apoptosis) is implicated in the terminal stages of heart failure is not known. We therefore studied the magnitude of myocyte apoptosis in patients with intractable congestive heart failure.
Depersonalization and temporal disintegration in acute mental illness
Authors: A M Freeman, F T Melges
Journal: American Journal of Psychiatry (1977)

The authors assessed the relationship between depersonalization (defined by self-estrangement and body image diffusion) and temporal disintegration (impaired goal-directedness and temporal indistinction) in 37 acutely ill hospitalized psychiatric patients. Substantial correlations were found between these two phenomena, confirming previous work. The finding that body image diffusion is positively correlated with temporal disintegration suggests that distortions of personal space accompany distortions of personal time.
Case 24-2007
Authors: Andrew J. Cole, John W. Henson, Michael H.A. Roehrl, Matthew P. Frosch
Journal: New England Journal of Medicine (2007)

A 20-year-old pregnant woman was admitted at 26 weeks' gestation because of dizziness, confusion, and difficulty walking. Six weeks earlier, she was confused and had odd head movements. Four days before admission, she had dizziness and weakness; she began to fall to her left and vomited. On admission, examination of the cerebrospinal fluid showed a lymphocytic pleocytosis with mildly elevated protein and normal glucose levels. During the next 18 days, her condition worsened.
Parabiotic Shifts and the &lt;italic&gt;H-2&lt;/italic&gt; Locus&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Eichwald, E. J., Weissman, I. L., Kowalchuk, J., Lustgraaf, E. C.
Journal: JNCI Journal of the National Cancer Institute (1963)

Journal Article Parabiotic Shifts and the H-2 Locus Get access E. J. Eichwald, E. J. Eichwald Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar I. L. Weissman, I. L. Weissman Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Kowalchuk, J. Kowalchuk Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar E. C. Lustgraaf E. C. Lustgraaf Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 30, Issue 4, April 1963, Pages 783–794, https://doi.org/10.1093/jnci/30.4.783 Published: 01 April 1963 Article history Received: 23 November 1962 Published: 01 April 1963
Overview: model programs for chronic mental patients
Authors: L L Bachrach
Journal: American Journal of Psychiatry (1980)

Model programs for chronic mental patients may be viewed from four perspectives: evaluation of individual programs, commonalities in successful programs, generalizability and reproducibility of specific programs, and relevance of model programs to problems of service delivery in mental health systems. Although successful model programs share certain common structural elements, such programs cannot be readily reproduced or generalized. Having limited value for the problems of service delivery in mental health systems, model programs are best seen as experimental efforts, not as solutions. Strategies for translating model-derived knowledge into systems-related action are needed.
P76 Psychogenic voice disorder mimicking treatment-refractory respiratory disease
Authors: J Selby, G Sandhu, G Scadding, A Menzies-Gow, JH Hull
Journal: Thorax (2015)

<h3>Introduction and objectives</h3> Psychogenic voice disorder (PVD) is widely acknowledged by voice and ENT specialists as an important cause of dysphonia and breathlessness. The significance of abnormal vocal function in the aetiology of respiratory symptoms is under-recognised in respiratory medicine. The aim of this study is to highlight the importance of PVD as a key differential diagnosis for patients who present with respiratory symptoms and altered voice quality. <h3>Methods</h3> We retrospectively reviewed referrals with respiratory symptoms and dysphonia to the upper airway service at the Royal Brompton, over a 12 month period to 2015. PVD was identified according to accepted criteria:<sup>1</sup> no structural or neurological laryngeal disease, discrepancy between laryngeal status and voice quality, temporary loss of volitional control over phonation, (e.g. frequently reported as secondary to dyspnoea), normal voicing on vegetative manoeuvres (e.g. coughing) and positive psychological factors associated with onset of symptoms. Perceptual voice quality was rated using the GRBAS scale. <h3>Results</h3> Ten female patients were identified as having PVD (70% type 2, 20% type 3, 10% type 1). All patients had preserved spirometric indices but daily symptoms of dyspnoea and dysphonia. Respiratory diagnoses at referral included chronic cough (20%), difficult asthma (50%) and unexplained dyspnoea (30%), with symptoms of between 2 months and 15 years’ duration. The majority of patients (70%) were receiving treatment with either oral +/- inhaled corticosteroid prior to referral. Perceptual voice quality varied among patients, but in all cases normal voice was restored by the end of the first treatment session, leading to subjective reduction in breathlessness. Relevant psychological factors were identified as an underlying cause of the voice disorder. <h3>Conclusion</h3> PVD is an under-recognised cause of treatment-refractory respiratory symptoms in patients with altered voice quality. Prior to referral, these symptoms are often attributed to the use of inhaled corticosteroid, yet accurate diagnosis and targeted therapy permits rapid restoration of normal voice and symptomatic improvement. This case series underpins the importance of collaborative working between SLT and respiratory medicine to ensure patients receive timely and appropriate specialist treatment. <h3>Reference</h3> 1 Butcher P, Elias A, Cavalli L. Understanding and treating psychogenic voice disorder: A CBT framework, 2007
Staphylococcal Endocarditis after Mitral Valvulotomy
Authors: John C. Dalton, Bryan Williams, Leonard Atkins
Journal: New England Journal of Medicine (1956)

BACTERIAL endocarditis after cardiac surgery has been previously reported in 6 patients.1 2 3 4 5 Four had undergone mitral valvulotomy, the fifth had a transventricular commissurotomy for aortic stenosis, and the sixth had been operated on for pulmonic stenosis. In 2 of these cases, the organism proved to be an antibiotic-resistant staphylococcus, and the patients succumbed to the infection.1 , 2 In a third patient, whose blood culture had yielded a staphylococcus, large doses of penicillin, sulfisoxazole and chloramphenicol resulted in recovery.3 Pseudomonas aeruginosa was recovered from the blood and from the vegetations on the heart valves in the fourth case, reported in England by . . .
PTH-302 Enhanced recovery after surgery after malignant colorectal resection in elderly: a single centre experience
Authors: M Gok, KI Malik, A Jeff, UA Khan
Journal: Gut (2015)

<h3>Introduction</h3> Enhanced recovery after surgery (ERAS) employs a multi-modal rehabilitation programme to aid post operative recovery following colorectal resections. ERAS can be applied in both laparoscopic and open surgery. The aim of the study is to assess ERAS versus conventional post operative care in malignant colorectal cancer resections (CRC) at a single institution. <h3>Method</h3> This is a retrospective study carried out at Macclesfield District General Hospital. ERAS became an integrated into colorectal surgery in 2008. Descriptive data, patient factors and post-operative features were collected for all elective malignant colorectal resections. <h3>Results</h3> See Table 1 <h3>Conclusion</h3> Despite a prolonged operative time, ERAS resulted in a shorter hospital stay (p &lt; 0.05). Departures from ERAS can result in delayed hospital discharge, which can occur in the presence of major surgical complications (ileus, anastomotic leak, collections). A targeted rehabilitation programme especially in the elderly patients can provide a cost effective earlier recovery. <h3>Disclosure of interest</h3> None Declared.
A critical review of epidemiological studies of Puerto Rican mental health
Authors: P J Guarnaccia, B J Good, A Kleinman
Journal: American Journal of Psychiatry (1990)

Through a review of the epidemiological literature on the mental health of Puerto Ricans and other Hispanics, the authors argue that lack of attention to cultural issues in epidemiological studies leaves many questions unanswered and raises concerns about the validity of studies in this area. The authors point out that the mental health status of Puerto Ricans in New York City is still poorly understood after 30 years of research. The roles of cultural response styles and of culturally meaningful expressions of distress in shaping responses to research interviews should be central concerns in developing research in cross-cultural psychiatry.
33P Prognostic factors associated with lung cancer survival. A population-based study in the South of Spain
Authors: I. Linares, J. Expósito, J.P. Arrebola, J. Sánchez-Cantalejo, Y.L. Chang-Chan, E. Molina, R. Guerrero, M.J. Sánchez
Journal: Journal of Thoracic Oncology (2016)