tbuckley/cabot-search huggingface dataset:
P108 Quality of life, diet and exercise measurements in obese individuals with and without ventilatory failure: Abstract P108 Table 1
Authors: CD Turnbull, AR Manuel, L Pirkis, JR Stradling
Journal: Thorax (2015)

<h3>Introduction</h3> Obesity is associated with reduced quality of life (QOL), particularly physical health. In addition obesity has been linked to reduced exercise and high calorie diet. We aimed to describe these factors in obese individuals with and without ventilatory failure, and investigate the hypothesis that ventilatory failure would have a negative impact on QOL. <h3>Methods</h3> QOL, diet and exercise was assessed as part of an open cross-sectional study of ventilatory failure in obese subjects referred either for assessment of sleep disordered breathing or bariatric surgery. The SF-12 was completed; a validated questionnaire to assess QOL giving summary scores for physical health (PCS) and mental health (MCS), and compared to data from a large non-obese UK cohort.<sup>1</sup> Participants underwent actigraphy (<i>SenseWear BodyMedia) </i>and from this the daily energy expenditure was estimated. A sedentary lifestyle was defined as &lt;5000 steps/day. Participants completed a validated food frequency questionnaire, which calculates daily dietary calorie intake from patient reported three month food habits. This was compared to UK guideline recommended daily maximum intake. Arterial base excess was measured as a marker of ventilatory failure and the correlations between quality of life indices and arterial base excess were calculated. <h3>Results</h3> 72 individuals with a mean age of 52.0 years (SD 8.9) and median BMI of 46.7 kg/m<sup>2</sup> (IQR 39.5, 52.6) participated in the study. Median duration of actigraphy was 23.2 days (IQR 21.2, 23.4). Arterial base excess was significantly but weakly correlated to MCS (r = 0.33, p = 0.01) but not to PCS (r = 0.05, p = 0.74). <h3>Conclusions</h3> Obesity had a large negative impact on both physical and mental QOL not reproducibly reported elsewhere. Ventilatory failure was only a weak predictor of mental, but not physical QOL scores. The majority of participants were sedentary and dietary calorie intake was higher than the recommended daily allowance for most women and a significant number of men. Actigraphy energy expenditure estimates exceeded patient reported dietary intake, which is probably due to patient underreporting. This highlights the clinical importance of considering mental health, physical activity and diet together when obese individuals are seen in a tertiary centre. <h3>Reference</h3> 1 <i>J Pub Health Med</i>. 2001;<b>23</b>:187–94
MB-69RELEVANCE OF CYTOSPIN QUALITY FOR DETECTION OF MICROSCOPIC LEPTOMENINGEAL DISSEMINATION IN MEDULLOBLASTOMA PATIENTS
Authors: Veronika Faltermeier, Christian Hagel, Katja Petrasch, Renate Schmid, Frank Deinlein, Martin Mynarek, André O. von Bueren, Carsten Friedrich, B. Ole Juhnke, Nicolas U. Gerber, Katja von Hoff, Stefan Rutkowski
Journal: Neuro-Oncology (2016)
Carcinogenic Activity of Cigarette-Smoke Condensate. I. Effect of Trauma and Remote X Irradiation&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Fred G. Bock, George E. Moore
Journal: JNCI Journal of the National Cancer Institute (1959)

In Swiss mice painted with cigarette-smoke condensate, benign and malignant skin tumors were produced in all groups, regardless of coincident irritation. The data indicate that qualitative differences in laboratory results probably are not due to minor differences in skin-painting techniques but may be due to differences in mouse stocks employed. In Swiss female and C3H male mice, intense irradiation of a small area increased the sensitivity of distant areas of skin to painting with cigarette-smoke condensate. In this case, X irradiation apparently acted as a systemic initiating agent of carcinogenesis. The Swiss female mice were much more sensitive to the combined treatment than were the C3H males.
Cockroaches and cherry stones
Authors: D. L. Wilbur
Journal: JAMA (1968)

Let me express again my deep gratitude for the great honor you have conferred on me by permitting me to address you as your President. In my inaugural remarks, I tried to make clear that the most important function of local and state medical associations and the AMA is to plan—plan thoroughly and wisely toward the goal of medical care of high quality for everyone in America. I posed many questions for the medical profession and for all medical associations. Now I would like to discuss these questions in greater detail and to suggest some answers. <h3>Changes in Medicine in the 19th Century</h3> But first to show that accident as well as planning is vital in medical progress—as well as in planning to take advantage of unexpected developments—here are two delightful vignettes of great changes in medicine in the 19th century. Cockroaches and cherry stones! What have they to do
Endoscopic Ultrasonography and Endoscopic Ultrasound-Guided Fine-Needle Aspiration Biopsy for the Diagnosis of Lower Digestive Tract Disease
Authors: K Hara, K Yamao, K Ohashi, T Nakamura, T Suzuki, A Sawaki, K Matsumoto, K Okubo, K Tanaka, I Moriyama, K Matsueda, T Kosikawa, U Ueyama, T Yokoi
Journal: Endoscopy (2003)

We evaluated the efficacy of endoscopic ultrasonography (EUS) and endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) biopsy for the diagnosis of lower digestive tract lesions. Between 1997 and 2001, ten patients whose barium enema or colonoscopy results were highly suspicious of lower digestive tract disease underwent EUS and EUS-FNA biopsy. In all these ten patients, while endoscopic biopsy could not provide a definitive diagnosis, mass lesions were detectable by EUS. However EUS images alone were insufficient for accurate diagnosis. The diagnostic accuracy rate of EUS-FNA biopsy was 90 % (9/10).
QOS-56THE PREVALENCE OF FEMALE SUBFERTILITY AFTER ‘PACKER’ CHEMOTHERAPY IN PNET TUMOURS: 19 YEAR FOLLOW UP STUDY FROM A SINGLE CENTRE
Authors: Soumya Pandalai, Joana Serra-Caetano, Olivia Jones, Kim Phipps, Helen Spoudeas
Journal: Neuro-Oncology (2016)
Abdominal Surgery
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1973)

ColonCrohn's DiseaseIn addition to the references given above, it should be noted that when ulcerative disease of the colon is present without small-bowel involvement, a strict differentiation between Crohn's disease and idiopathic ulcerative colitis is impossible, and that in our experience approximately 20 per cent of the cases will fall into an indeterminate group. Schachter et al. studied 100 cases of ulcerative colonic disease in the University of Chicago treated by proctosigmoidectomy.107 Approximately 80 per cent of the specimens were proved to be idiopathic ulcerative colitis, and the others had Crohn's disease. The clinical diagnosis was correct in . . .
Cognitive changes in acute schizophrenia with brief neuroleptic treatment
Authors: M Wahba, P T Donlon, A Meadow
Journal: American Journal of Psychiatry (1981)

The authors studied 44 acutely decompensated, hospitalized schizophrenic patients who were placed on a double-blind basis for 10 days in three treatment groups: patients given high, moderate, and standard doses of haloperidol. To assess changes in the patients' concentration, abstract thinking, and ability to respond appropriately they administered two clinical rating scales and three psychological tests. Patients in all three treatment groups showed similar and significant improvements according to both clinical and psychological ratings after haloperidol administration. Normal control subjects showed no change in psychological test scores over time. The authors conclude that brief treatment with neuroleptics produces measurable improvement in schizophrenic thinking.
Case 44-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Michael D. Walker, Edward P. Richardson, Robert E. Scully
Journal: New England Journal of Medicine (1978)

Presentation of Case First admission. A 57-year-old woman was admitted to the hospital because of pain in the arm.She was well until seven months previously, when she noticed pain in the left side of the chest on elevation of the arm; straining and coughing provoked pain and tingling that extended from the left axilla to the elbow. Five months before entry she began to awake during the night with pain that spread from the left scapula into the left arm. During the three months before admission she observed milder pain in the right arm and noticed that flexion . . .
RELATIONSHIP BETWEEN SOCIAL ATTITUDES TOWARD AGING AND THE DELINQUENCIES OF YOUTH
Authors: MAURICE E. LINDEN
Journal: American Journal of Psychiatry (1957)

In the awesome network of social forces that relate to character and behavior distortion the hypothetical factor herein presented concerns itself with but one thread, perhaps a guyline. There seems to be a commonsense logic in the viewpoint that degradation of the elder role-model of social authority is paralleled by an increase in arrogance and wilfulness in the young. The fact remains that aging in our culture is generally unattractive and unrewarding. A newspaper supplement recently stated the case succinctly, "the world is made for youth and youth is the time for fun." Can we expect the young to make provident and prudent psychological preparations for the advancing years, when the later period is so often seen in threatening aspect. Desirable character formation in the young requires that the group character of a culture present a social atmosphere of dignified elderhood in which symbolic authority is implicit, an authority enriched with warmth, humanism, and charity, yet firm in its leadership, independently motivated, and oriented around group principles. Nature has endowed youth heavily with a capacity to achieve its own rewards. Aging needs social support. If the rewards of youth are to be wisely invested to insure that lives are well spent, then the elders must be reinstated in their time-honored position as brokers in experience and consultants in living.
Medical Ethics
Authors: ROGER J. LEWIS
Journal: Annals of Internal Medicine (1975)

Comments1 December 1975Medical EthicsROGER J. LEWIS, M.D.ROGER J. LEWIS, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-6-900 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Medical ethics is a charged field, but I read with alarm Dr. Ingelfinger's "The Unethical in Medical Ethics" (1) and noted these points: it was received and accepted on the same day, 14 May 1975; most other articles in the August issue were received much earlier and accepted only after substantial delays; and Dr. Ingelfinger is associated with a major journal that is generally thought to be a competitor of "The Annals."The rapid publication of this paper, which cannot have been critically reviewed, can, from the viewpoint of other authors in the journal, only seem to...Reference1. INGELFINGER F: The unethical in medical ethics. Ann Intern Med 83:267-270, 1975 LinkGoogle Scholar1. GREENBERG D: "Progress" in cancer research—don't say it isn't so. N Engl J Med 292:707-708, 1975 CrossrefMedlineGoogle Scholar1. CALLAHAN D: The ethics backlash. Hastings Center Rep 5(4):18, 1975 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Harlem Hospital Center 135th Street and Lenox Avenue New York, New York 10037 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLove’s ObligationsH 1 December 1975Volume 83, Issue 6Page: 900-901KeywordsMedical ethics ePublished: 1 December 2008 Issue Published: 1 December 1975 PDF downloadLoading ...
Effect of lithium therapy on glomerular filtration rate
Authors: P Decina, J A Oliver, R R Sciacca, E Colt, R R Fieve
Journal: American Journal of Psychiatry (1983)

Patients taking lithium had a slightly higher serum creatinine concentration than controls. Creatinine concentration was independent of lithium level or therapy length, suggesting that lithium decreases glomerular filtration but that this effect is small, noncumulative, and of marginal clinical significance.
EPN-03C11orf95-RELA FUSION POSITIVE PEDIATRIC SUPRATENTORIAL EPENDYMOMAS ARE AN AGGRESSIVE SUBSET WITH INCREASED EXPRESSION OF STEM CELL MARKER NESTIN AND VASCULAR ENDOTHELIAL DERIVED GROWTH FACTOR
Authors: Aruna Nambirajan, Prit Benny Malgulwar, Pankaj Pathak, Mohammed Faruq, Madhu Rajeshwari, Rakesh Kumar Gupta, Vaishali Suri, Chitra Sarkar, Manmohan Singh, Mehar Chand Sharma
Journal: Neuro-Oncology (2016)
UNUSUAL LESIONS OF VERMIFORM APPENDIX.
Authors: D C COLLINS
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RO-22FIRST EXPERIENCE OF MONITORING RADIOLOGICAL RESPONSE USING MRI DURING A PROTON IRRADIATION OF A PAEDIATRIC CHORDOMA: A NEW APPROACH?
Authors: Sabina Vennarini, Nicola Bizzocchi, Barbara Rombi, Stefano Lorentini, Amedeo Calisto, Andrea Carai, Antonella Cacchione, Benedetta Pettorini, Angela Mastronuzzi, Maurizio Amichetti
Journal: Neuro-Oncology (2016)
The evolution of psychiatric services in a health maintenance organization
Authors: T E Bittker, S Idzorek
Journal: American Journal of Psychiatry (1978)

The authors describe a prepaid mental health service program in which outpatients referrals were 34.7 per 1,000 members per month, the hospital admission rate was .80 admissions per 1,000 members per year, and the average length of hospital stay was 5.03 days. They offer several explanations for their finding that the costs for mental health services in this program appear lower than those in fee-for-service programs.
RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation
Authors: Qi Xie, Qiulian Wu, Leo Kim, Tyler E. Miller, Brian B. Liau, Stephen C. Mack, Kailin Yang, Daniel C. Factor, Xiaoguang Fang, Zhi Huang, Wenchao Zhou, Kareem Alazem, Xiuxing Wang, Bradley E. Bernstein, Shideng Bao, Jeremy N. Rich
Journal: Journal of Clinical Investigation (2016)

Glioblastomas co-opt stem cell regulatory pathways to maintain brain tumor–initiating cells (BTICs), also known as cancer stem cells. NOTCH signaling has been a molecular target in BTICs, but NOTCH antagonists have demonstrated limited efficacy in clinical trials. Recombining binding protein suppressor of hairless (RBPJ) is considered a central transcriptional mediator of NOTCH activity. Here, we report that pharmacologic NOTCH inhibitors were less effective than targeting RBPJ in suppressing tumor growth. While NOTCH inhibitors decreased canonical NOTCH gene expression, RBPJ regulated a distinct profile of genes critical to BTIC stemness and cell cycle progression. RBPJ was preferentially expressed by BTICs and required for BTIC self-renewal and tumor growth. MYC, a key BTIC regulator, bound the RBPJ promoter and treatment with a bromodomain and extraterminal domain (BET) family bromodomain inhibitor decreased MYC and RBPJ expression. Proteomic studies demonstrated that RBPJ binds CDK9, a component of positive transcription elongation factor b (P-TEFb), to target gene promoters, enhancing transcriptional elongation. Collectively, RBPJ links MYC and transcriptional control through CDK9, providing potential nodes of fragility for therapeutic intervention, potentially distinct from NOTCH.
Depression in veterans two years after Viet Nam
Authors: E P Nace, A L Meyers, C P O'Brien, N Ream, J Mintz
Journal: American Journal of Psychiatry (1977)

The authors evaluated the incidence of depression in a sample of 202 Viet Nam veterans an average of 28 months after their return from Viet Nam. Approximately one-third of the sample fell within the clinically depressed range of the Beck Depression Inventory. Comparison of the depressed and nondepressed groups indicated that the former had higher frequencies of drug abuse (particularly while in Viet Nam), more marital difficulties, a higher unemployment rate, and more current legal problems. This high incidence of depression, coupled with the finding that few of these men were being treated for the illness, indicates the need for an outreach approach to this population.
Case 28-1962
Authors: Eugene A. Stead
Journal: New England Journal of Medicine (1962)

Presentation of Case*A seventy-five-year-old active housewife entered the hospital because of dyspnea.The patient's health was good until the onset of progressive orthopnea and dyspnea on exertion three weeks before admission. There was no cough, hemoptysis, palpitation or ankle edema. During the two days before entry she experienced severe dyspnea at rest and felt alternately hot and cold.There was no history of hypertension. A bilateral extraction of lenticular cataracts was performed a year and a half previously.Physical examination revealed a well nourished, acutely dyspneic woman. The pharynx was injected, and the neck veins were distended 4 cm. . . .
Obinutuzumab-induced coagulopathy in chronic lymphocytic leukaemia with trisomy 12
Authors: H S Walter, S Jayne, P Mensah, F M Miall, M Lyttelton, M J S Dyer
Journal: Blood Cancer Journal (2016)

Figure 1.(a) Sequencing trace showing the NOTCH1 mutation c.7544_7545delCT mutation (RefSeq NM_017617.2);arrows point to the position of the nucleotide change.(b-e) show abnormal blood parameters observed on completion of the infusion.
A randomized, open-label, phase III trial of NOV-002 in combination with paclitaxel (P) and carboplatin (C) versus paclitaxel and carboplatin alone for the treatment of advanced non-small cell lung cancer (NSCLC).
Authors: P. Fidias, T. A. Ciuleanu, O. Gladkov, G. M. Manikhas, I. N. Bondarenko, A. Pluzanska, R. Ramlau, T. J. Lynch
Journal: Journal of Clinical Oncology (2010)

LBA7007 Background: NOV-002 is a formulation of disodium glutathione disulfide (GSSG). GSSG is a naturally occurring substance that functions as a component of the glutathione (GSH) pathway, vital to the regulation of the intracellular redox state. A key function of the GSH/GSSG redox couple is to dynamically regulate protein functions, including cell signaling pathways, through the reversible formation of mixed disulfides between protein cysteines and GSH (S-glutathionylation). Based on positive results from a randomized, phase I/II study of carboplatin and paclitaxel (CP) with or without NOV-002, as well as positive results from 2 ex-U.S. phase II studies with cisplatin-based chemotherapy, an international phase III randomized trial was launched. Methods: Patients with advanced NSCLC (stages wet IIIB and IV, inclusive of all histological subtypes) were eligible if they had a PS of 0-1 and adequate end-organ function. Patients with CNS metastases were excluded. Eligible patients were randomized to C (AUC 6), P (200 mg/m 2 ), and NOV-002 (Group A) or C and P alone (Group B). NOV-002 was administered as two-60 mg IV boluses on day -1 of cycle 1 and as one IV bolus on day 1 of each cycle, followed by daily 60-mg subcutaneous injections. A total of 725 events were required to detect a difference in overall survival (OS) from 10.0 to 12.5 months with 85% power and a two-sided significance level of 0.05. No interim analysis was performed. Results: From 11/06 until 9/09, 903 patients were randomized, with target enrollment reached in March 2008. Patient characteristics for Groups A and B were as follows: stage IV (91.5/90.8%), PS 1 (76.6/72.6%), male (69.9/72.4%), never smoker (22.3/19.1%) median age (59.6/59.5), and histology (adenocarcinoma [40.0/36.8%] squamous [41.2/40.8%]). The median overall survival for Groups A and B was 10.2/10.8 months (p = 0.375), median progression-free survival was 5.3/5.6 months, objective response rate was 26.6/26.0% and 54/53% of patients completed at least six cycles of chemotherapy. Major toxicities for Groups A and B included grade 3/4 neutropenia (29.7/26.3%), febrile neutropenia (2.2/1.8%), grade 3/4 thrombocytopenia (3.8/2.9%), and grade 3/4 neuropathy (2.9/2.4%). Adverse events resulting in death in Groups A and B were reported in 5.6 and 3.1%, respectively. Conclusions: The addition of NOV-002 to CP does not improve overall survival in patients with advanced NSCLC. NOV002 does not appear to add to the overall toxicity of chemotherapy. [Table: see text]
Accurate Quantification of Disease Markers in Human Serum Using Iron Oxide Nanoparticle-linked Immunosorbent Assay
Authors: Linlin Zhang, Sheng Tong, Jun Zhou, Gang Bao
Journal: Theranostics (2016)

Accurate and reliable quantification of biomarkers in the blood is essential in disease screening and diagnosis. Here we describe an iron oxide nanoparticle (IONP)-linked immunosorbent assay (ILISA) for detecting biomolecules in human serum. Sandwich ILISA was optimized for the detection of four important serological markers, IgA, IgG, IgM, and C-reactive protein (CRP), and assessed with normal sera, simulated disease-state sera and the serum samples from patients infected with West Nile virus (WNV) or human herpes virus (HHV). Our study shows that using the detection assay formulated with 18.8 nm wüstite nanocrystals, ILISA can achieve sub-picomolar detection sensitivity, and all four markers can be accurately quantified over a large dynamic range. In addition, ILISA is not susceptible to variations in operating procedures and shows better linearity and higher stability compared with ELISA, which facilitates its integration into detection methods suitable for point of care. Our results demonstrate that ILISA is a simple and versatile nanoplatform for highly sensitive and reliable detection of serological biomarkers in biomedical research and clinical applications.
Effects of Nerve Growth Factor on Processes Regulating Bone Marrow Progenitor Cells Mobilization after Myocardial Infarction
Authors: Marco Meloni, Andrea Caporali, Daniela Cesselli, Elisa Avolio, Orazio Fortunato, Jonathan Rowlinson, Gaia Spinetti, Raimondo Ascione, AP Beltrami, Paolo R Madeddu, Costanza Emanueli
Journal: Circulation (2012)
Late stage lung cancer diagnosis is more likely in younger patients
Authors: Anne Gulland
Journal: BMJ (2016)

Patients aged 50 to 64 in England are more likely to be have late stage lung cancer diagnosed than older patients, new data have shown.

The analysis, presented at the Cancer Outcomes and Data Conference on 14 June, showed that a higher proportion of patients aged 50 to 64 had lung cancer diagnosed at a late stage than patients aged 65 to 69. People in their 70s are more likely to have an …
QOS-28EVALUATING THE ROLE OF A NEURO-ONCOLOGY-ENDOCRINE NURSE KEYWORKER IN OPTIMISING PATHWAYS, QUALITY OF SURVIVAL OUTCOMES AND PATIENT AND FAMILY EXPERIENCE IN A LARGE SINGLE CENTRE BRAIN TUMOUR SURVIVORSHIP COHORT
Authors: Nicola Farrell, Kim Phipps, Kate Golding, Zoe Berger, Helen Spoudeas, Ainsley Moven
Journal: Neuro-Oncology (2016)