tbuckley/cabot-search huggingface dataset:
FRI0263 Activation of the interferon pathway is dependent upon autoantibodies in african american sle patients, but not in european-american sle patients
Authors: K. Ko, Y. Koldobskaya, E. Rosenzweig, T. B. Niewold
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Lupus is a heterogeneous autoimmune disease characterized by anti-RNA-binding protein autoantibodies and high circulating levels of interferon. The disease is more prevalent and more severe in African-Americans as compared to European-Americans. <h3>Objectives</h3> We aimed to explore how IFN-related gene expression pathways differ in patients according to their ancestry and anti-RBP profile. <h3>Methods</h3> Whole blood from 33 female SLE patients and 16 matched controls from EA and AA ancestral backgrounds was analyzed through Affymetrix gene expression arrays, and the data were further studied through Ingenuity Pathways Analysis for canonical pathway comparison. An independent replication cohort of more than 100 SLE patient samples and 30 controls was used to test the hypotheses generated by the microarray data, using qPCR to quantify gene expression. <h3>Results</h3> Both EA and AA patients with positive anti-RBP (RBP+) showed involvement of IFN-related canonical pathways including IFN Signaling (P = 5.8 x 10-11 and 1.3 x 10-7 respectively), and a number of pattern recognition receptor pathways. All of these pathways were also involved in EA patients with negative anti-RBP (RBP-) but they were completely absent in AA patients with RBP-. The microarray results were confirmed by a replication study through qPCR on 3 IFN-inducible genes, IFIT1, MX1 and PKR. <h3>Conclusions</h3> Our data show that IFN-induced gene expression is completely dependent on the presence of autoantibodies in AA SLE patients but not in EA patients. <b>Disclosure of Interest</b>: None Declared
Parasite stress is not so critical to the history of religions or major modern group formations
Authors: Scott Atran
Journal: Behavioral and Brain Sciences (2012)

Abstract Fincher &amp; Thornhill's (F&amp;T's) central hypothesis is that strong in-group norms were formed in part to foster parochial social alliances so as to enable cultural groups to adaptively respond to parasite stress. Applied to ancestral hominid environments, the story fits with evolutionary theory and the fragmentary data available on early hominid social formations and their geographical distributions. Applied to modern social formations, however, the arguments and inferences from data are problematic.
Abstract 3016: Roles of histone deacetylase inhibitors in the regulation of DNA methyltransferase 1
Authors: Asami Takashima, Douglas V. Faller
Journal: Cancer Research (2011)

Abstract DNA methylation and histone deacetylation are the two major classes of genomic modifications which can contribute to transcriptionally-repressive chromatin structure.Tumor suppressor genes are hypermethylated in their promoter regions in certain cancers, which leads to transcriptional repression of these genes, and histone deacetylases (HDACs) cooperate with DNA methyltransferases (DNMTs) in this process, by their subsequent recruitment to methylated DNA. HDAC inhibitors, which can variably induce differentiation, apoptosis and/or cell cycle arrest in tumor cells, are known to alter gene expression patterns by disrupting the transcriptional regulatory complexes with which DNMT1 and HDAC1 or HDAC2 associate. Surprisingly, a series of recent studies by our group and others, using HDAC inhibitors, suggests that HDAC activity may influence DNA methylation, in addition to the established and reciprocal ability of CpG methylation to influence HDAC recruitment and transcriptional repression. HDAC inhibitors appear to influence DNA methylation by regulating the expression of DNMT1, although the molecular pathway mediating this regulation has not been fully elucidated. We have documented DNMT1 downregulation at the level of mRNA and protein abundance in human cancer cell lines, following exposure to any of several structurally-different HDAC inhibitors, suggesting that HDAC inhibitors decrease DNMT1 expression at the level of mRNA. We determined at which level, transcription or RNA degradation, DNMT1 mRNA is affected by HDAC inhibition, by measuring the time course of RNA degradation using real-time PCR following treatment of Actinomycin D, an inhibitor of de novo transcription. In spite of their ability to upregulate AUF1, a known regulator of DNMT1 mRNA stability, HDAC inhibitors did not significantly alter DNMT1 mRNA half-life in comparison to vehicle-treated controls. In agreement with this finding, specific knockdown of AUF1 by siRNA did not abrogate the decrease in DNMT1 protein expression caused by HDAC inhibition. Exposure to HDAC inhibitors in the presence of cycloheximide, an inhibitor of de novo protein synthesis, prevented the downregulation of DNMT1 mRNA, suggesting that new protein synthesis is required for the effect of HDAC inhibitors on DNMT1 expression. Thus, the downregulation of DNMT1 expression by HDAC inhibitor treatment is induced at the transcriptional level in LNCap cells, possibly in an indirect manner. These findings begin to elucidate the mechanism whereby HDACs and their inhibitors may influence DNA methylation, in addition to the established and reciprocal ability of CpG methylation to influence HDAC recruitment and transcriptional repression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3016. doi:10.1158/1538-7445.AM2011-3016
Acute obscure-overt gastrointestinal bleeding: capsule endoscopy first?
Authors: P. Mensink
Journal: Endoscopy (2012)

Every experienced clinical gastroenterologist can recall a recent case of this particular type of patient: presenting with an acute gastrointestinal bleeding, and with negative findings on initial "emergency" upper endoscopy and colonoscopy. In quite a number of these patients the gastrointestinal bleeding is recurrent or ongoing, necessitating further diagnostics to locate the source of bleeding, followed by guided therapeutic intervention. We know that about 5 % of all patients with an iron deficiency anemia with a suspected gastrointestinal bleeding, whether presenting with visible or nonvisible blood loss, will finally be classified as having an obscure gastrointestinal bleeding (OGIB). The percentage of patients with obscure – overt gastrointestinal bleeding (OOGIB) is not exactly known, but is likely to be a smaller portion of all patients with OGIB. As in OGIB patients, in OOGIB patients the logical next step is evaluation of the small bowel, for identification of a likely small bowel lesion as the source of the bleeding. In recent years, since the introduction of capsule endoscopy in 2000, followed by double-balloon enteroscopy (DBE) in 2001, the earlier-used push enteroscopy and laparotomy-assisted enteroscopy have both been widely replaced by these two newer techniques. In more recent years, single-balloon and spiral enteroscopy have been added to the enteroscopic options, generally referred to as "device-assisted enteroscopy" (DAE). Radiological options are abdominal CT angiography with contrast, conventional intra-arterial contrast angiography, and "classical" tagged (technetium-99m-labeled) red blood cell scan. To date, no studies have compared the use of any of these, mainly diagnostic, techniques in this particular and challenging group of patients.
P640New in vitro model for proarrhythmia screening: iks inhibition potentiates the qtc prolonging effect of ikr inhibitors in isolated guinea pig hearts
Authors: P Kui, SZ Orosz, A Sarusi, CS Cseko, T Forster, A Varro, A Farkas, AS Farkas
Journal: Cardiovascular Research (2014)

Purpose: We hypothesised that Langendorff-perfused guinea pig hearts with pharmacologically reduced repolarization reserve would be suitable for assessing the proarrhythmic liability of drugs. We tested the electrocardiographic QT interval prolonging effect of the IKr K+ channel inhibitors dofetilide and cisapride in such experimental setting, and examined whether selective inhibition of the IKs K+ current by HMR-1556 can augment IKr-blocker-induced QT prolongation.
THU0019 Genome-wide pathway analysis of genome-wide association studies on psoriasis and behcet’s disease
Authors: Y.H. Lee
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Genome-wide association studies (GWASs) have been successfully used to identify novel common genetic variants that contribute to susceptibility to complex diseases, but individual GWASs are limited in terms of identifying new loci. Thus, pathway-based analysis is required to identify further new loci that contribute to susceptibility to complex diseases. <h3>Objectives</h3> The aim of this study was to explore candidate single nucleotide polymorphisms (SNPs) and candidate mechanisms of psoriasis and Behcets's disease (BD) and to generate an SNP à gene à pathway hypothesis, using pathway analysis. <h3>Methods</h3> A psoriasis GWAS dataset that included 436,192 SNPs in 1,409 psoriasis cases and 1,436 controls of European descent and a BD GWAS dataset that contained 310,324 SNPs in 1,215 BD cases and 1,278 controls were used in this study. Pathway-based analysis using ICSNPathway (Identify candidate Causal SNPs and Pathways) analysis was applied to the GWAS datasets. <h3>Results</h3> ICSNPathway analysis identified 15 candidate SNPs and 28 candidate causal pathways. The top 5 candidate causal SNPs were rs1063478 (<i>P</i> =1.45E-10), rs8084 (<i>P</i> =2.20E-08), rs7192 (<i>P</i> =5.18E-08), rs20541 (<i>P</i> =5.30E-06), and rs1130838 (<i>P</i> =5.65E-06), which with the exception of rs20541 (interleukin [IL]-13) are at HLA loci. These candidate SNPs and pathways provided ten hypothetical biological mechanisms. The most strongly associated pathway concerned human leukocyte antigen (HLA). When HLA loci were excluded, ICSNPathway analysis provided one hypothetical biological mechanism. rs20541 (non_synonymous_coding) à IL-13 à dendritic cell involvement in the regulation of Th1 and Th2 development, and the GATA3 pathway. ICSNPathway analysis identified four candidate causal SNPs, eleven candidate causal pathways, and three hypothetical biological mechanisms. One of them was as follows; rs2072895 (non_synonymous_coding &amp; splice_site)) and rs2735059 (non_synonymous_coding) à HLA-F à Type I diabetes mellitus, antigen processing and presentation, and autoimmune thyroid disease. <h3>Conclusions</h3> The application of ICSNPathway analysis to GWAS datasets of psoriasis and BD resulted in the identification of candidate SNPs and candidate pathways that might contribute to psoriasis susceptibility. <h3>Disclosure of Interest</h3> None Declared
Editorial authors' reply to Freedhoff
Authors: A. Floegel, T. Pischon
Journal: BMJ (2012)

Freedhoff’s claim that our recommendation for clinicians to advise against the long term use of low carbohydrate-high protein diets because of higher morbidity and mortality from cardiovascular diseases is not evidence based is not correct.1 2

Currently, no randomised controlled trials (RCTs) or meta-analyses of RCTs have investigated the association between low carbohydrate-high protein diets and hard clinical endpoints of cardiovascular disease. Because of this …
Diagnostic Procedures in Cardiology: A Clinician's Guide.
Authors: J.V. Warren, R.P. Lewis
Journal: Annals of Internal Medicine (1986)

This book contains 31 papers. Some of the titles are: Cardiovascular radiology; Nuclear cardiology; echocardiography; The use and conduct of exercise tests; Lipid studies in cardiology; and The practice of cardiology in an era of high technology.
Successful placement of a fully covered esophageal stent to bridge a difficult-to-close mucosal incision during peroral endoscopic myotomy
Authors: Dennis Yang, Qing Zhang, Peter Draganov
Journal: Endoscopy (2014)

Closure of the mucosal entry during peroral endoscopic myotomy (POEM) can be achieved using standard clips in most cases, but on rare occasions clip closure may not be possible. Alternative salvage methods for closure have been described, including the over-the-scope clip [1] [2] and an endoluminal suturing device [3]. We report the first POEM case in which a fully covered stent was used to seal a mucosal incision that was difficult to close.
Abstract LB-111: Overexpression of esophageal squamous cell carcinoma (ESCC)-associated genes located within the homogeneously staining region (HSR) in chromosome 17p
Authors: Christina D. Liu, K. C. Pak, L. Hu, X.y. Guan, George S.W. Tsao, S. Law, K Y. Lam, Johnny C. O. Tang
Journal: Cancer Research (2010)

Abstract The homogeneously staining region (HSR) has been shown to contain amplified genes that give selective advantages to the progression of cancer-cell growth. In this study, fluorescent in situ hybridization and array comparative genomic hybridization analysis were conducted on SLMT-1 (an ESCC cell line of Hong Kong Chinese origin) and revealed a HSR which was derived from chromosome 17p13.3. To identify the potential novel oncogene(s) with overexpression in ESCC, the overexpression study of the non-tumor suppressor genes within the region 17p13.3 was conducted in 15 ESCC cell lines by utilizing reverse transcription and multiplex PCR analysis. Eight non-tumor suppressor genes within this region were studied and three genes Timm22, JC-1 and JC-2 showed high percentages of overexpression compared with the non-tumor esophageal epithelial cell line NE1. Forty-six percent (7/15) of cell lines showed overexpression for Timm22 and both JC-1 and JC-2 were overexpressed in seventy-three percent (11/15) of ESCC cell lines. Further investigation on the JC-1, which showed the highest overexpression rate among the cell lines, was performed for its oncogenic properties. The entire coding sequence of JC-1 cloned into the mammalian expression vector pcDNA3.1(-) was transfected into mouse fibroblast NIH-3T3 cells. The JC-1-transfected NIH-3T3 cells showed an enhanced growth rate as determined by MTS assay, ncreased ability to form foci under anchorage dependent growth and increased migration rate in vitro. Thus, the results of the present study contribute to the investigation of potential novel oncogenes with overexpression in ESCC and may enrich our understanding of molecular pathogenesis of ESCC in the long run. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-111.
TCT-668 Aortic Annulus and Root Characteristics In Severe Aortic Stenosis Due To Bicuspid Aortic Valve And Tricuspid Aortic Valves: Implications For Transcatheter Aortic Valve Therapies
Authors: Femi Philip, E. Murat Tuzcu, Lars Svensson, Samir Kapadia
Journal: Journal of the American College of Cardiology (2014)
IMPACT OF ANNUAL INSTITUTIONAL VOLUMES ON COMPARATIVE SAFETY OUTCOMES OF CATHETER DIRECTED THROMBOLYSIS VERSUS ANTICOAGULATION THERAPY IN THE TREATMENT OF LOWER EXTREMITY PROXIMAL DEEP VEIN THROMBOSIS
Authors: Harish Jarrett, Chad Zack, Vladimir Lakhter, Estefania Oliveros, Yevgeniy Brailovsky, Michael Lashner, Vikas Aggarwal, Grayson Wheatley, Alfred Bove, Riyaz Bashir
Journal: Journal of the American College of Cardiology (2015)
Testicular I-131 6β-Iodomethyl-19-Norcholesterol Uptake in a Patient With Adrenogenital Syndrome
Authors: ZAKARIA I. ASSI, NICOLAAS I. BOHNEN, DAVID E. SCHTEINGART, MILTON D. GROSS, BRAHM SHAPIRO
Journal: Clinical Nuclear Medicine (1999)

A 38-year-old man with congenital adrenal hyperplasia, salt losing variety, on a maintenance dose of 25 mg of cortisone acetate daily, presented with decreased libido and premature ejaculation, but no other constitutional symptoms. He was noted to have bilateral testicular masses. Ultrasound showed infiltrative tumors in both testicles. Laboratory testing revealed an elevated ACTH of 500 pg/ml (normal range 9-52 pg/ml) reflecting inadequate corticosteroid replacement. A I-131 6β-Iodomethyl-19-Norcholesterol (NP-59) scan demonstrated prominent testicular uptake indicating the steroid producing nature of the testicular masses.
RADIOIODINATION OF MONOCLONAL ANTIBODIES. LABELING WITH PARA-IODOPHENYL (PIP) DERIVATIVES USING PROTEIN SULFHYDRYLS
Authors: M. D. Hylarides, D. S. Wilbur, J. R. Schroeder, L. M. Grant, J. R. Seubert, P. Beaumier, A. R. Fritzberg
Journal: Clinical Nuclear Medicine (1988)

Hylarides, M. D.; Wilbur, D. S.; Schroeder, J. R.; Grant, L. M.; Seubert, J. R.; Beaumier, P.; Fritzberg, A. R. Author Information
TRANSCATHETER AORTIC VALVE REPLACEMENT CUSTOMIZATION BASED ON PARAVALVULAR AORTIC REGURGITATION LOCATION
Authors: Olivia N. Gilbert, Daniel D. Hermann, Lucia Alvarez, Christian Deutsch, Alex Aldrich, Matthew Sacrinty, Min Pu, Richard Stacey, Robert Applegate, Sanjay Gandhi, David Zhao
Journal: Journal of the American College of Cardiology (2015)
SP0105 Motivational interviewing from the patient’s perspective to increase physical activity in arthritis
Authors: L. Ehrlich-Jones
Journal: Annals of the Rheumatic Diseases (2013)

Many people with arthritis are not physically active even though physical activity has been shown to improve function, decrease pain, maintain joint health, and prevent disability. There are many reasons for reluctance to engage in formal exercise programs, such as fear of pain or injury, joint symptoms, having functional limitations, as well as many health care providers failing to promote physical activity during an office visit. Changing behavior is no easy task. Self-determination theory is a framework that it used in the study of motivation for behavior change. Important concepts of this theory include the person’s experience of autonomy, competence and relatedness to others. Motivation from extrinsic as well as intrinsic factors can play a role in behavior change. Self-regulation is the capacity to alter your own behavior. Behaviors are changed based on some standards, ideals or goals that come from either intrinsic or extrinsic expectations. Motivational interviewing (MI) is a counseling style used successfully in some health care settings where the patient and health professional work together to achieve behavior change. MI is a patient centered, directed approach to enhance intrinsic motivation to change by exploring and resolving the individual’s ambivalence to change. The counselor or coach utilizes an interpersonal style characterized by the acceptance of the person expressed by respect, empathy, and support and the absence of confrontation or persuasion. The main skills of MI include open ended questions, affirmations, reflective listening, and summarization. The coach and patient work together to achieve collaboratively set goals emphasizing that the patient has the main role in the process. Health coaching studies have shown that this type of behavioral change intervention is promising, although more studies are needed. It is unknown how the patient perceives the interaction of MI in relation to physical activity behavior change. The Client Perception of Motivational Interviewing Encounter Instrument has been created to assess how patients with arthritis view this type of counseling style. Qualitative data from patient focus groups and preliminary psychometric data for this new instrument will be discussed. Future studies highlighting interventions to promote healthy lifestyle will be reviewed. <h3>Disclosure of Interest</h3> None Declared
Abstract 3111: Expression of chromobox homolog 7 (Cbx7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via regulating TRAIL-induced apoptotic pathway.
Authors: Yoriko Yamashita, Kanako Shinjo, Eiko Yamamoto, Shinya Akatsuka, Takashi Takahashi, Hiroaki Kajiyama, Fumitaka Kikkawa, Shinya Toyokuni
Journal: Cancer Research (2013)

Abstract Ovarian cancer is the most lethal gynecologic malignancy, and among them, clear cell adenocarcinoma of the ovary (OCCA) has relatively worse prognosis associated with chemoresistancy. Chromobox (Cbx) 7 is a component of the polycomb repressive complex 1 that prolongs the lifespan of normal human cells via down-regulating the expression of INK4a/ARF and thus related with cell-cycle progression. However, recent reports studying the relationship between Cbx7 expression and the patient's survival differs among the cell origins of the tumors, and the precise role of Cbx7 in human carcinomas remains obscure. In this study, we analyzed the expression of Cbx7 by immunohistochemistry in 81 OCCA patients and evaluated the association with their clinical outcome. Both overall survival and progression-free survival of the patients were significantly shorter in Cbx7-positive than Cbx7-negative (P&amp;lt;0.05) tumors in OCCA. Cbx7 knockdown experiments using two OCCA cell lines, TOV21G and KOC-7C, revealed that the viability of the cells were significantly reduced compared to control (P&amp;lt;0.001). Expression microarray analysis revealed that apoptosis-related genes, especially TRAIL, were significantly upregulated in Cbx7 knockdown cells (P&amp;lt;0.01). We further confirmed that Cbx-7 knockdown resulted in TRAIL-induced apoptosis in OCCA cells. Thus, in this study, we showed for the first time that Cbx7 is associated with worse prognosis in OCCA. We also successfully demonstrated that the TRAIL pathway is a novel target of Cbx7 in these cells, and therapeutic agents utilizing the TRAIL pathway may be specifically effective targeting OCCA. Citation Format: Yoriko Yamashita, Kanako Shinjo, Eiko Yamamoto, Shinya Akatsuka, Takashi Takahashi, Hiroaki Kajiyama, Fumitaka Kikkawa, Shinya Toyokuni. Expression of chromobox homolog 7 (Cbx7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via regulating TRAIL-induced apoptotic pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3111. doi:10.1158/1538-7445.AM2013-3111 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Contamination of Botanical Dietary Supplements by<i>Digitalis lanata</i>
Authors: Nancy R. Slifman, William R. Obermeyer, Brenda K. Aloi, Steven M. Musser, William A. Correll, Stanley M. Cichowicz, Joseph M. Betz, Lori A. Love
Journal: New England Journal of Medicine (1998)

OR many years, the Food and Drug Administration (FDA) regulated botanical dietary-supplement ingredients, in most circumstances, under the provisions for food additives of the Federal Food, Drug, and Cosmetic Act to ensure that they were safe and wholesome.Currently, dietary supplements (such as botanical products, vitamins and minerals, amino acids, and tissue extracts) are regulated under the Dietary Supplement Health and Education Act of 1994, which includes several provisions that apply only to dietary supplements and dietary ingredients of dietary supplements.Included in these provisions was the removal of the ingredients of dietary supplements from regulation as food additives and the requirement that the FDA bear the burden of proof that a marketed dietary supplement presents a serious or unreasonable risk under the conditions of use on the label or as commonly consumed.This requirement is in contrast to what is required for drugs, which must be shown to be safe and effective for a particular indication before they are approved for marketing.The case of a previously healthy patient who presented with a toxic serum digoxin level after the ingestion of botanical dietary supplements was reported to the FDA in 1997.We sought to determine the source of the patient's exposure to cardiac glycosides and to investigate the extent and duration of distribution of the suspect raw material and the products containing it.We also investigated a sec-