tbuckley/cabot-search huggingface dataset:
Increased Preoperative Collection of Autologous Blood with Recombinant Human Erythropoietin Therapy
Authors: Lawrence Tim Goodnough, Seth Rudnick, Thomas H. Price, Samir K. Ballas, Myra L. Collins, James P. Crowley, Martin Kosmin, Margot S. Kruskall, Bruce A. Lenes, Jay E. Menitove, Leslie E. Silberstein, Kenneth J. Smith, Charles H. Wallas, Robert Abels, Mark Von Tress
Journal: New England Journal of Medicine (1989)

To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before surgery, we conducted a randomized, controlled trial of erythropoietin in 47 adults scheduled for elective orthopedic procedures. The patients received either erythropoietin (600 units per kilogram of body weight) or placebo intravenously twice a week for 21 days, during which time up to 6 units of blood was collected. Patients were excluded from donation when their hematocrit values were less than 34 percent. All patients received iron sulfate (325 mg orally three times daily). The mean number of units collected per patient (±SE) was 5.4±0.2 for the erythropoietin group and 4.1 ±0.2 for the placebo group. The mean red-cell volume donated by the patients who received erythropoietin was 41 percent greater than that donated by the patients who received placebo (961 vs. 683 ml, P<0.05). Only 1 of the 23 patients treated with erythropoietin was unable to donate ≥4 units(4 percent) as compared with 7 of the 24 patients who received placebo (29 percent). No adverse effects were attributed to erythropoietin. We conclude that recombinant human erythropoietin increases the ability of patients about to undergo elective surgery to donate autologous blood. (N Engl J Med 1989; 321:1163–8.)
Clinical and Laboratory Studies of Mumps
Authors: John P. Utz, Vernon N. Houk, David W. Alling
Journal: New England Journal of Medicine (1964)

IN previous studies1 , 2 of patients with mumps viruria has been detected as early as the first day and as late as the fifteenth day of illness. In one2 of these studies 72 per cent of the urine specimens collected during the first five days of illness were culturally positive. These observations suggested the possibility of renal involvement in mumps and prompted a prospective study of renal function and viral cultures of the urine in patients. The results of that study form the basis of this report.Patients and MethodsPatientsAll patients were young-adult Navy servicemen consecutively admitted with mumps . . .
Abstract 362: Comparison of Mig-6 and hormone receptor expression to BMI as predictors of responsiveness to progestin therapy for endometrial hyperplasia and cancer
Authors: Jessica Poisson, Emma Rossi, Steven Young, Paola A. Gehrig, Victoria L. Bae-Jump
Journal: Cancer Research (2011)

Abstract Objectives: Mitogen-inducible gene 6 (Mig-6) is an immediate early response gene that can be induced by stressful stimuli and mitogens, including hormones and growth factors. Ablation of Mig-6 leads to epithelial hyperplasia and adenocarcinomas in a variety of organs, including the endometrium. Mig-6 has been identified as a downstream target of the progesterone receptor (PR) in the uterus. Thus, our goal was to compare Mig-6 and hormone receptor expression to BMI as predictors of responsiveness to progestin therapy for endometrial hyperplasia and cancer. Methods: Women were identified who underwent progestin treatment (oral or IUD) for either endometrial hyperplasia or cancer. Expression of Mig-6 and the hormone receptors, G-protein coupled receptor 30 (GPR30), estrogen receptor (ER) and PR were evaluated by immunohistochemistry (IHC) in 58 paired formalin-fixed, paraffin-embedded endometrial biopsy specimens before and after progestin treatment. Tissue microarrays were constructed, and three cores were analyzed for each patient. IHC staining was scored according to the intensity (1+ to 3+) and qualitative percent cells staining per core. A “histoscore” was calculated, based on multiplying these two determinants ranging from 0 to 300 (i.e. intensity x % labeled). Results were analyzed using the Student t-test and ANOVA. Results: There were 41 responders to progestin therapy and 17 non-responders. The majority had endometrial hyperplasia (56/58) but 2 women had grade I endometrial carcinomas. The BMI between the two groups was statistically different at 40.2 for the responders and 49.9 for the non-responders (p=0.0008). There was no difference in age or ER/PR status between the two groups. Mig-6 expression prior to treatment did not predict response to progestin therapy (183.5 = responders, 196.6 = non-responders, p=0.47). GPR30 expression prior to progestin treatment was 118.8 for the responders and 68.9 for the non-responders but was not statistically significant (p=0.06). Neither post-treatment Mig-6 (179.1 = responders, 204.0 = non-responders) or GPR30 (103.6 = non-responders, 108.6 = responders) histoscores or change in histoscores pre- and post-treatment predicted response to progestin therapy. Conclusions: BMI but not Mig-6 expression or hormone receptor expression predicted response to progestin therapy in women with endometrial hyperplasia and cancer. GPR30 may have potential as a biomarker of progestin responsiveness but needs to be evaluated in a larger cohort of women. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 362. doi:10.1158/1538-7445.AM2011-362
Skeletal Tumor Burden on Baseline 18F-Fluoride PET/CT Predicts Bone Marrow Failure After 223Ra Therapy
Authors: Elba C. Etchebehere, John C. Araujo, Denái R. Milton, William D. Erwin, Richard E. Wendt, Nancy M. Swanston, Patricia Fox, Homer A. Macapinlac, Eric M. Rohren
Journal: Clinical Nuclear Medicine (2016)

Purpose Determine if skeletal tumor burden on 18F-fluoride PET/CT (fluoride PET/CT) predicts the risk of bone marrow failure (BMF) after 223Ra dichloride therapy (223Ra). Methods Forty-one metastatic prostate cancer patients (43-89 years old; mean, 71 ± 9 years.) underwent fluoride PET/CT prior to 223Ra. Bone marrow failure was the primary end point and was defined as (1) development of hematologic toxicity (World Health Organization grade 3 or 4) associated with no recovery after 6 weeks or (2) death due to BMF after the last 223Ra dose. Bone marrow failure was correlated to fluoride PET/CT skeletal tumor burden (TLF10 [total lesion on fluoride PET/CT with SUVmax of 10 or greater]), use of chemotherapy, serum hemoglobin concentration, serum ALP, and serum prostate-specific antigen. Results The number of 223Ra cycles ranged from 2 to 6 (mean, 5). Of the 41 patients, 16 developed BMF (G3 = 12; G4 = 4). A significantly increased risk of developing BMF was observed in patients with TLF10 of 12,000 or greater (hazard ratio [HR], 11.09; P < 0.0001), hemoglobin of less than 10 g/dL (HR, 7.35; P = 0.0002), and AP > 146 UI/L (HR, 4.52; P = 0.0100). Neither concomitant (HR, 0.91; P = 0.88) nor subsequent use of chemotherapy (HR, 0.14; P = 0.84) increased the risk of BMF, nor was prostate-specific antigen greater than 10 μg/L (HR, 0.90; P = 0.86). Moreover, in a multivariable analysis, TLF10 was the only independent predictor of BMF (HR, 6.66; P = 0.0237). Conclusions 223Ra was beneficial and reduced the risk of death even in patients with a high skeletal tumor burden. Fluoride PET/CT is able to determine which patients will benefit from 223Ra and which will develop BMF.
TCT-112 Impact of Race/Ethnicity On 30 Day Readmission After Percutaneous Coronary Intervention: Results From a Multiethnic, Single Center Registry
Authors: Ioannis Mastoris, usman baber, Melissa Aquino, Swathi Roy, Roja Thapi, Jason Kovacic, Robert T. Pyo, Joe Sweeny, George Dangas, Roxana Mehran, Annapoorna Kini, Samin Sharma
Journal: Journal of the American College of Cardiology (2014)
RAPID ONSET OF POTASSIUM:LOWERING WITH SODIUM ZIRCONIUM CYCLOSILICATE (ZS-9) ACROSS PATIENTS STRATIFIED BY RACE, AGE, AND COMORBIDITIES IN THE RANDOMIZED, DOUBLE:BLIND, PLACEBO:CONTROLLED PHASE 3 HARMONIZE STUDY
Authors: Joseph S. Alpert, Bhupinder Singh, Jose Menoyo, Henrik Rasmussen, Mikhail Kosiborod
Journal: Journal of the American College of Cardiology (2016)
AB0723 Subclinical ultrasound synovitis in a particular joint is associated with ultrasound evidence of bone erosions in the same joint, in patients with rheumatoid arthritis in clinical remission
Authors: F. Vreju, E. Filippucci, M. Gutierrez, L. Di Geso, P. Ciurea, F. Salaffi, W. Grassi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> the aim of the present study was to investigate the relationship between ultrasound (US) findings indicative of joint inflammation and both clinical and US features characterizing synovitis at joint level in patients with rheumatoid arthritis in sustained clinical remission. <h3>Methods</h3> 24 consecutive patients with rheumatoid arthritis in clinical remission according to EULAR criteria (DAS28&lt;2.6) underwent clinical and ultrasound (US) assessment. US examination included second to fifth metacarpophalangeal joints of both hands and used a multiplanar scanning technique according to the EULAR guidelines. <h3>Results</h3> A total of 192 metacarpophalangeal joints were assessed in 24 rheumatoid arthritis patients in clinical remission, defined by EULAR criteria (DAS28&lt;2,6). Ultrasound examination found more active joints that clinical evaluation, both by grayscale (GS) and Power Doppler (PD). 105 joints from the total number of 192 had GS changes (54,68%). By scanning more than one aspect of a joint, we found 56 areas positive for erosions, in both hands, with more than half being hot erosions (53,57% positive for PD). Both, the median/average Power Doppler score and GS score were higher in the joints with erosions compared to those without erosions (p&lt;0,01). <h3>Conclusions</h3> Joint with bone erosions are more frequently ultrasound inflamed, which explains the fact that treating the rheumatoid arthritis in the window of opportunity, before the radiological changes occur, would offer a higher chance of remission. In the same time suggests that some of the joints need local anti-inflammatory treatment, besides the systemic therapy with DMARDS <h3>Disclosure of Interest</h3> None Declared
SP0185 Exercising safely? A physiotherapy perspective
Authors: M. van der Esch
Journal: Annals of the Rheumatic Diseases (2013)

Moderately intensive aerobic and strengthening exercises are recommended in treatment guidelines and are effective in reducing pain and activity limitations in patients with rheumatic diseases, including rheumatoid arthritis and knee and/or hip osteoarthritis. Although exercises are effective and deemed to be safe, adverse events have been reported from exercise trials in the field of rheumatology. The incidence of adverse events, including an increase in pain during and after exercise, an increase in joint inflammation, increased cartilage degeneration, musculoskeletal injuries and falls due to exercise, is low. Although the frequency of adverse events seems to be low, the question arises as to how people with rheumatic diseases can exercise more safely and therefore avoid adverse events. There is a need to investigate adverse events resulting from exercising as part of the improvement of care for patients with rheumatic diseases. Such studies could focus on the type of patients who are at a greater risk of being confronted with adverse events of exercise and the intensity of exercising. The results of studies investigating these issues will contribute to improving the knowledge of effective exercising in patients with rheumatic diseases. <h3>Disclosure of Interest</h3> None Declared
The reproductive toxicity of boric acid.
Authors: R E Chapin, W W Ku
Journal: Environmental Health Perspectives (1994)

Previous studies on the reproductive toxicity of boric acid have indicated that male rodents suffer testicular atrophy after treatment. There were, however, no studies of the potential effects on female fertility or on the neonate. In addition, no study described the development of the testicular lesion, thought to be related to the mechanism of toxicity. A Reproductive Assessment by Continuous Breeding (RACB) study using mice exposed to boric acid at 1000, 4500, and 9000 ppm in the diet indicated that there are probably multiple sites of action, although male fertility appears very sensitive. Possible effects on female fertility cannot be separated from potential developmental toxicity and need additional investigation. Decrements in sperm motility were observed at all exposure levels, and testicular atrophy was confirmed in high- and middle-dose-group males. This was investigated further by timed serial-sacrifice studies using 9000 ppm in the diet of rats, which found that the first lesion seen in the testis was an inhibition of spermiation (release of mature spermatids). With continued dosing, this was followed by a disorganization of the normal ordered layering of the seminiferous epithelium, germ cell sloughing and death, and finally, atrophy. Subsequent studies using additional doses (2000, 3000, 4500, 6000, and 9000 ppm) found that it was possible to observe inhibited spermiation that did not progress to atrophy (4500 ppm and below) within the 9-week exposure period.(ABSTRACT TRUNCATED AT 250 WORDS)
Reversal of Early Neurologic and Neuroradiologic Manifestations of X-Linked Adrenoleukodystrophy by Bone Marrow Transplantation
Authors: Patrick Aubourg, Stéphane Blanche, Isabelle Jambaqué, Francis Rocchiccioli, Gabriel Kalifa, Catherine Naud-Saudreau, Marie-Odile Rolland, Mariane Debré, Jean-Louis Chaussain, Claude Griscelli, Alain Fischer, Pierre-François Bougnères
Journal: New England Journal of Medicine (1990)

X-LINKED adrenoleukodystrophy is an inherited peroxisomal disease caused by a defective gene located within the Xq28 region of the X chromosome.1 Childhood adrenoleukodystrophy is characterized by ...
The Role of Ischemia Modified Album in Acute Pulmonary Embolism
Authors: Zeynettin Kaya, Mehmet Kayrak, Enes Elvin Gül, Gökhan Altunbaş, Aysun Toker, Aysel Kıyıcı, Mehmet Gündüz, Hayruddin Alibasic, Hakan Akıllı, Alpay Arıbaş, Abdullah Tuncez
Journal: Journal of the American College of Cardiology (2013)
INCIDENCE AND POTENTIAL MECHANISM(S) OF POST-PROCEDURAL RISE OF CARDIAC BIOMARKERS IN THE RANDOMIZED ABSORB II TRIAL COMPARING AN ABSORB SCAFFOLD AND A XIENCE STENT.
Authors: Dariusz Dudek, Yuki Ishibashi, Maik Grundeken, Hector Garcia Garcia, Yoshinobu Onuma, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2015)
SG-03 * A ROLE FOR NADPH OXIDASE 4-GENERATED REACTIVE OXYGEN SPECIES IN SONIC HEDGEHOG-DRIVEN PROLIFERATION OF CEREBELLAR GRANULE NEURON PRECURSORS
Authors: C. Potts, R. Rotenberry, A. Kenney
Journal: Neuro-Oncology (2015)

Medulloblastoma is the most common solid malignant pediatric brain tumor. These tumors arise in the cerebellum and can be molecularly subdivided into 4 consensus subgroups, one of which is marked by amplification and activation of Sonic hedgehog (Shh) pathway components and downstream targets. This subclass is proposed to arise from the oncogenic transformation of cerebellar granule neuron precursors (CGNPs), whose expansion during post-natal brain development requires activation of the Shh pathway and downstream targets. These tumors often demonstrate similarities with normal cerebellar development at the molecular level, thus allowing us to use primary CGNP cultures as a model system for the Sonic hedgehog (Shh) driven subclass of medulloblastoma. In addition to mitogens driving proliferation in cancer, it has been shown in the past that low levels of intracellular reactive oxygen species (ROS) can contribute to proliferation through, amongst other methods, phosphatase inhibition and subsequent deregulation of key pathways including pathways that collaborate with Shh signaling. To this end we've studied a reported ROS-generating effector of insulin and insulin-like growth factor signaling, NADPH oxidase 4 (Nox4). It is thought that Nox4 is both upregulated by insulin signaling and synergizes with it downstream via ROS-induced sustained phosphorylation of Akt. Our work in CGNPs revealed a marked induction of Nox4 in response to Shh at the mRNA and protein levels as well as an increase in total reactive oxygen species content. Subsequent studies suggest that Nox4 activity is critical to sustaining proliferation of Shh driven CGNPs. Western blots of shRNA knockdowns of Nox4 showed reduction of proliferative marker CyclinD2. The knockdowns also precipitated a drop in phosphorylated Akt perhaps leaving the Shh pathway without the full effects of one of its major signaling partners, the PI3K/Akt pathway.
Interstitial Lung Diseases of Unknown Cause
Authors: Ronald G. Crystal, Peter B. Bitterman, Stephen I. Rennard, Allan J. Hance, Brendan A. Keogh
Journal: New England Journal of Medicine (1984)

THE interstitial lung diseases are a heterogeneous group of disorders of the lower respiratory tract characterized by derangements of the alveolar walls and loss of functional alveolar capillary units.1 2 3 More than 100 agents are known to cause interstitial disease, but in two thirds of all cases, no cause can be identified.3 This group, commonly referred to as interstitial lung diseases of unknown cause, is responsible for more than 10,000 hospital admissions in the United States each year and has a prevalence of 5 to 10 cases per 100,000 population.3The list of interstitial lung diseases of unknown cause includes 35 . . .
Abstract P2-13-02: Phase II Study of Glucosamine with Chondroitin on Joint Symptoms Induced by Aromatase Inhibitors in Breast Cancer Patients
Authors: H Greenlee, KD Crew, T Shao, G Kranwinkel, L Brafman, K Kalinsky, M Maurer, WY Tsai, DL. Hershman
Journal: Cancer Research (2010)

Abstract Background: Aromatase inhibitors (AIs) are commonly used as adjuvant endocrine therapy in postmenopausal women with hormone receptor-positive breast cancer (BC). However, many patients treated with AIs experience joint symptoms which may lead to non-adherence to treatment. We examined whether glucosamine plus chondroitin improves AI-induced arthralgias in women with early stage BC. Methods: This is a single-arm Phase II study evaluating the efficacy of glucosamine and chondroitin in postmenopausal BC patients with moderate to severe AI-induced arthralgias. Patients took glucosamine sulfate (1500mg/d) + chondroitin sulfate (1200mg/d) for 24 weeks, and were assessed every 6 weeks. The primary endpoint was change in Outcome Measure in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) criteria at 24 weeks. Secondary endpoints include changes in Brief Pain/Stiffness Inventory-Short Form (BPI-SF), Western Ontario and McMaster Universities Osteoarthritis (WOMAC), Modified Score for the Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH), quality of life, grip strength and estradiol level. A Simon two-stage design was used. If 7/22 responses were observed, the trial would continue. Results: Of 36/46 patients enrolled to date, 21 were evaluable at 24 weeks. Median age: 61 (46-80); White/Hispanic/Black/Asian: 11/5/4/1. At 24 weeks, 12/21 patients (57%) had improved pain/stiffness or function in their knees or hips, and 14/21 patients (67%) had improvement in their hands, and 80% had improvement in hands and/or knees. There were also decreases in BPI pain/stiffness severity and functional interference (P&amp;lt;0.05). Reassuringly, there was no increase in serum estradiol levels. Conclusion: Glucosamine and chondroitin is a well-tolerated and potentially effective treatment for AI-induced arthralgia. Evaluation of these agents in a placebo controlled phase III study is warranted. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-13-02.
P175 Measurement Of Air Leak Post-thoracic Surgery: Implications For Medical Management Of Pneumothorax
Authors: R. Hallifax, J. Mitchell, J. Corcoran, I. Psallidas, N. Rahman, E. Belcher
Journal: Thorax (2014)

<h3>Introduction</h3> Use of digital suction devices post-thoracic surgery is widespread, allowing patients to be more mobile and potentially reducing the time to chest drain removal post-op (in comparison with standard underwater seal). Spontaneous pneumothorax (SP) is common (5,000/yr in the UK). However, there are no good predictors of outcome for patients with pneumothorax. Measurement of early air leak could potentially predict which patients who will not resolve spontaneously and will require surgery. Post-surgical data may provide an interesting analogy to ongoing air leak in spontaneous pneumothorax. The hypothesis is that reduction in air leak to &lt;50 ml/min within 30 min of attachment can predict air leak over next 48 h and overall drain duration. <h3>Methods</h3> Retrospective review of the use of digital suction device (Thopaz, Medela UK) post-op in the Thoracic Surgical department of a tertiary referral centre between May and December 2012. The detailed air leak measurements were assessed against duration of drainage. <h3>Results</h3> Operations included 88 lung resections (wedge resections, lobectomies and metastasectomies via VATS and thoracotomy), 28 pleural procedures (VATS pleurodesis +/- bullectomy) and 12 empyema drainage/decortication. Average air leak over the entire duration was significantly different between the groups: 80.6 ml/min, 54.3 ml/min and 304.5 ml/min respectively (p = 0.01). Patients with early reduction of air leak (i.e. reduced to &lt;50 ml/min within the initial 30 mins) were compared to patients with &gt;50 ml/min air leak (see Table). The mean air leak over the subsequent 48 h was significantly different between the groups for patients post-lung resection (34.4 vs 164.9 ml/min, p = 0.01), and post-pleural operation (9.1 vs 196.7 ml/min, p = 0.03); but not after empyema surgery (9.8 vs 1001.4 ml/min, p = 0.08). The duration of chest drain <i>in situ</i> post-op was lower in the group with early reduction in air leak (but did not reach statistical significance). <h3>Conclusion</h3> This sample of post-surgical data suggests that early resolution of air leak is associated with ongoing low air leak (and early drain removal). Equivalent prospective studies are now required in the medical management of pneumothorax to determine whether early physiological measurements can predict outcome.