tbuckley/cabot-search huggingface dataset:
Retrocardiac Uptake of Tc-99m Sestamibi: Manifestation of a Hiatal Hernia
Authors: JAMES D. SLAVIN, ISMAIL O. ENGIN, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (1998)

A 79-year-old woman underwent cardiac bypass surgery for three vessel disease. Three years later she was admitted to the hospital because of atypical chest pain. Myocardial imaging revealed retrocardiac uptake of intravenously administered Tc-99m sestamibi. This was due to a hiatal hernia which had accumulated the radiotracer.
Abstract 771: Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis.
Authors: Amy Farrell, Carl Pelz, Xiaoyan Wang, Colin Daniel, Yulong Su, Mahnaz Janghorban, Soren Impey, Rosalie C. Sears
Journal: Cancer Research (2013)

Abstract The c-Myc oncoprotein is generally considered to be a master regulator of gene transcription by virtue of its ability to activate or repress the expression of a large percentage of all genes. However, mechanisms that direct c-Myc's recruitment to DNA and target gene selection to elicit specific cellular functions have not been well elucidated. Here, we report that the Pin1 prolyl-isomerase regulates c-Myc transcriptional activity by altering c-Myc's association with target gene promoters. Specifically, we show that Pin1 enhances the recruitment of Serine62-phosphorylated c-Myc along with its co-activators to selected target gene promoters during gene activation, followed by promoting c-Myc's release associated with its degradation, resulting in cyclic c-Myc DNA binding. This facilitates c-Myc's activation of target genes associated with an increase in elongating RNA Polymerase II in the gene body. Genes impacted by this mechanism are involved in cell growth and metabolism, resulting in enhanced pro-proliferative activity, even while controlling c-Myc expression. In cancer cells with impaired c-Myc degradation, Pin1 still regulates cyclic c-Myc DNA binding, even though it no longer enhances c-Myc degradation. This allows for simultaneous high expression of Pin1 and c-Myc in cancer, which can drive a gene expression pattern that we show is enriched in poor outcome subtypes of breast cancer. This study provides new insight into mechanisms regulating c-Myc DNA binding and oncogenic activity, it reveals a novel role for Pin1 in transcription factor regulation, and it elucidates a mechanism that can contribute to oncogenic cooperation between Pin1 and c-Myc. Citation Format: Amy Farrell, Carl Pelz, Xiaoyan Wang, Colin Daniel, Yulong Su, Mahnaz Janghorban, Soren Impey, Rosalie C. Sears. Pin1 regulates the dynamics of c-Myc DNA binding to facilitate target gene regulation and oncogenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 771. doi:10.1158/1538-7445.AM2013-771
Chronic Frontal Sinusitis Showing a Ring-Like Accumulation Demonstrated by Tc-99m HMDP Bone Imaging
Authors: TSUNEO HIRANO, HIDENORI OTAKE, MARI KANUMA, YASUO MOGI, TAKASHI TATEZAWA
Journal: Clinical Nuclear Medicine (1997)

Bone scintigraphy with Tc-99m HMDP in a 67-year-old man with squamous cell carcinoma of the lung showed increased uptake in the left frontal lesion. A CT scan showed mucosal thickening of the left frontal sinus. Chronic sinusitis caused mucosal thickening, which accumulated the radionuclide in a ring-like appearance.
AB0717 Inflammatory Bowel Disease Associated Arthropathy: Characteristics of the Disease and Validity of Diagnoses Based on Icd-Coding in Sweden
Authors: P. Drivelegka, N. Papachrysos, I.F. Petersson, A. Bremander, L.T. Jacobsson
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Epidemiological studies of IBD-associated arthritis (IBD-aA) are scarce, but both axial and peripheral muskuloskeletal manifestations are considered to be more common in IBD-aA than in the general population. <h3>Objectives</h3> To determine: 1) the validity of ICD-10 codes for IBD-aA in administrative databases, 2) the frequency and characteristics of axial and peripheral arthritis by type of IBD. <h3>Methods</h3> The SpA Scania cohort consists of all the subjects aged 15 years or older in the Skåne region (1.2 million inhabitants in southern Sweden) having recieved a diagnosis of any type of Spondyloarthritis during 2003-2007 at primary or specialised care visits (N=5771) recorded in the Skåne Health Care Register (SHCR). This included patients with Ankylosing Spondylitis (26%), Undiffentiated Spondyloarthritis (22%), Psoriatic Arthritis (39%) and IBD-aA (ICD-codes: M07.4, M07.5, 2.3%). Medical records were reviewed following a stuctured protocol in the subgroup of IBD-aA patients (N=65) that also responded to a postal survey sent to the Spa Scania cohort in 2009. <h3>Results</h3> Of the 65 patients with IBD-aA diagnosis in the register, 80% (n=52) and 94% had both IBD and arthritis according to the medical records when requiring ≥1 or ≥2 visits with diagnoses of IBD-aA respectively. Of the 52 patients (80%) where IBD and rheumatic disease could be verified (17 men), the mean age at the time of onset of arthritis symptoms was 39.8 years (SD: 13.9). Of the 29 patients with ulcerative colitis (UC) 83% had peripheral and 45% had axial arthritis. For Crohn9s disease (CD) (n=23) the corresponding figures were 91% and 48%. In 78% of the patients, bowel disease preceded the arthritis symptoms. Only in 8 patients (15,4%) the onset of arthritis preceded the IBD and 7 of them had axial arthropathy. Overlap between peripheral and axial arthritis was found in 18 patients (34,6%). In women peripheral arthritis was more common than axial (91% vs 40%), whereas in men a more equal distribution was observed (76% vs 65%). <h3>Conclusions</h3> The ICD10 codes for IBD-aA had a high validity supporting larger epidemiological studies. Peripheral arthritis was more common than axial disease in both UC and CD. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4540
P381 THE ROLE OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) IN CHOLESTASIS AND BILE ACID (BA) SYNTHESIS
Authors: J. Svinka, P. Stiedl, M. Mair, T. Claudel, E. Einwallner, P. Rampetsreiter, W. Mikulits, H.U. Marschall, J. Hengstler, V. Poli, H. Esterbauer, E. Casanova, M. Sibilia, M. Trauner, R. Eferl
Journal: Journal of Hepatology (2014)
Coexisting Renal Vein Thrombosis and Bilateral Adrenal Hemorrhage
Authors: KAZUYOSHI SUGA, AKIHIKO HARA, KAZUMI MOTOYAMA, YUKO ISHIKAWA, NORIHIKO KUME, NAOFUMI MATSUNAGA
Journal: Clinical Nuclear Medicine (2000)

A rare case of simultaneous renal vein thrombosis and bilateral adrenal hemorrhage is presented, showing the utility of Tc-99m DTPA and DMSA renal scans to identify the condition and to assess renal function. The characteristic appearances of suprarenal tracer-free areas encircled by peripheral radioactive rims over the inferiorly displaced kidneys on a Tc-99m DTPA renal scan, and that of the flattened upper poles of the kidneys on a Tc-99m DMSA scan, were pathognomonic and strongly indicative of bilateral adrenal hemorrhage. These two scans also showed markedly diminished tracer uptake in the poorly functioning right thrombosed kidney. Follow-up imaging using these two renal scans well demonstrated the functional and morphologic alterations and recovery of the kidneys.
Goodbye, for Now
Authors: Jerome P. Kassirer
Journal: New England Journal of Medicine (1999)

Because the officers of the Massachusetts Medical Society and I could not resolve our differences over administrative and publishing issues, they decided to seek a new editor-in-chief, and I leave the post in a few days. Shepherding the Journal through the past 425 issues has been an honor. From week to week the Journal is a complex weave of the best clinical research, health policy, ethics, medical wisdom, and spirited commentary. This unique blend makes it far more than the sum of its parts. The Journal is a venerable institution that remains unchallenged today.Reflecting on the calm atmosphere of . . .
ENDOTHELIAL DYSFUNCTION AND THE OCCURRENCE RADIAL ARTERY SPASM DURING TRANSRADIAL CORONARY PROCEDURES: THE ACRA-SPASM STUDY
Authors: Dirk Jan Van Der Heijden, Maarten A.H. van Leeuwen, Jailen Hermie, Ferdinand Kiemeneij, Niels Van Royen
Journal: Journal of the American College of Cardiology (2016)
AB0537 Usability of an innovative and interactive electronic system for collection of patient-reported data in axial spondyloarthritis: comparison with the traditional paper-administered format
Authors: F. Salaffi, S. Gasparini, A. Ciapetti, M. Gutierrez, M. Carotti, W. Grassi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To evaluate the validity, in terms of the patients' acceptance, preference, feasibility, and reliability of an innovative, interactive computerized system for collection of patient-reported outcome (PRO) data on axial spondyloarthritis (axial-SpA) against the paper-and-pencil version. <h3>Methods</h3> Fifty five patients with axial-SpA completed both the touch-screen and the paper-administered set of questionnaires. A computerized touch-screen system, namely SPEAMonitor, was developed to capture PRO data. Variables recorded include demographic data, patient's assessment of general health status, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), Bath AS Metrology Index (BASMI)and acute phase reactants levels. In order to assess the patient's acceptance, preference, and the feasibility of computer-based questionnaires, the participants filled in an additional questionnaire. Time taken to complete both formats was measured. In a further test-retest study, 25 patients were evaluated. <h3>Results</h3> The agreement between the paper-administered and computer touch-screen format of the BASFI, BASDAI questionnaires and the ASDAS scores was excellent. Intraclass correlation coefficients (ICC) between data ranged from 0.90 to 0.96. Additionally, the test-retest study showed a very good agreement between the scores for the two administrations (ICC ≥0.90). Age, computer experience, or educational level had no significant impact on the results. The computerized questionnaires were reported to be easier to use. Mean time spent completing the questionnaires on touch-screen was 5.1 min and on paper 7.9 min. <h3>Conclusions</h3> Our newly developed computer-assisted touch-screen questionnaires for PRO in axial-SpA were well accepted by patients, with good data quality, reliability, and score agreement. <h3>Acknowledgements</h3> The study was sponsored by an unrestricted educational grant from AbbVie S.r.l. - Abbott Italia. AbbVie played no role in the study design or in the collection, analysis, or interpretation of the data, the writing of the manuscript, or in the decision to submit the manuscript for publication. <h3>Disclosure of Interest</h3> F. Salaffi Grant/research support from: Bristol-Myers Squibb, Speakers bureau: Bristol-Myers Squibb, Abbott Immunology, Wyeth Lederle and Pfizer, S. Gasparini: None Declared, A. Ciapetti Speakers bureau: Bristol-Myers Squibb, M. Gutierrez Speakers bureau: Abbott Immunology, UCB Pharma, Esaote, and Bristol-Myers Squibb., M. Carotti: None Declared, W. Grassi Grant/research support from: Bristol-Myers Squibb and Abbott Immunology, Speakers bureau: Bristol-Myers Squibb, Abbott Immunology and Pfizer
FRI0509 Upper Gastrointestinal Bleeding is Associated with Significantly Higher Mortality in Systemic Sclerosis Patients
Authors: Y. Braun-Moscovici, D. Markovits, I. Gralnek, K. Toledano, R. Beshara-Garzoz, A. Dagan, A. Rozin, Y. Chowers, A. Balbir-Gurman
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The gastrointestinal tract is involved in nearly all patients with systemic sclerosis (SSc) and is a source of significant morbidity and even mortality. <h3>Objectives</h3> To assess whether there is correlation between upper gastrointestinal (UGI) endoscopy findings and mortality in SSc patients. <h3>Methods</h3> The records of 256 SSc patients seen in our rheumathologic clinic between 2003-2013 were reviewed. 140 patients who had at least one detailed upper endoscopy report and at least 6 months follow-up were included in the study. Patient data included demographics, type of SSc, disease duration, modified Rodnan skin score (mRSS), lung, cardiac, renal or musculoskeletal involvement, hemoglobin at endoscopy and type of antibodies. Endoscopic findings that were included in the analysis were esophagitis, ulcerations, tumors, gastric antral vascular ectasia (GAVE), gastric erosions, submucosal hemorrhages and lumenal blood. The statistical methods used included descriptive statistics, T test, bivariable analysis, cox regression analysis <h3>Results</h3> Forty seven patients (16 diffuse SSc) had evidence of GAVE or antral erosions and hemorrhage. The mortality rate in this group, during the follow up was 37% vs. 25% in the group of 93 (39 diffuse) SSc patients without GAVE or UGI bleeding (p=0.001). There were no statistical differences between the groups regarding mean ages (55) or Hb (10.87 in the group with the UGI bleeding vs 11.77). The mean mRSS score was higher in the group with UGI bleeding 8 vs.5.6 (p=0.019). Mean (median) disease duration was 6.9 (4.5) years in the group with UGI bleeding vs 10.4 (10) (p&lt;0.001). Esophagitis was found in 90% of patients, despite use of PPI. Co-morbidity of myositis had a negative impact on survival. The mortality hazard ratio (95% CI) for UGI bleeding, myositis and interstitial lung disease were 5.9 (2.7-13.2), 4.9 (2-12.4) and 2.7 (1.3-5.8) respectively. <h3>Conclusions</h3> A diagnosis of GAVE or UGI bleeding on upper endoscopy was associated with significantly higher mortality. In our cohort of SSc patients, myositis was associated also with increased mortality. The long-term survival of patients with GAVE/UGI bleeding was similar to the patients with myositis that were free of such GI complications. The patients with both myositis and GI bleeding had a very poor prognosis. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3613
Application of Cryogenic Surgery to Resection of Parenchymal Organs
Authors: Irving S. Cooper, Teruo Hirose
Journal: New England Journal of Medicine (1966)

THE use of extreme cold as a surgical tool has been applied to an increasing number of diverse surgical problems since the development of a vacuum-insulated cryogenic surgical system.1 Originally developed to provide a means of producing controlled areas of physiologic inhibition or sharply demarcated lesions within the brain by cooling, or by rapid freezing at extremely low temperatures,2 this cryosurgical system can provide a safe, controllable method of necrosis of biologic tissue in situ,3 4 5 as well as a relatively avascular means of surgical removal of neoplasms.6 Experience with cryosurgery for removal of brain tumors over the past three years . . .
Book: The Malthus Factor
Authors: F. Paccaud
Journal: BMJ (1999)

Eric B Ross ZED Books, £14.95, pp 270 ISBN 1 85649 564 7 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img> Malthus's ideas are still popular today, and this book tries to explain why and how Malthus offers a political theory of poverty that rests on two principles: firstly, that poverty is originated by the poor themselves (that is, via their reproductive behaviour) and, secondly, that only external pressures on the poor can correct any imbalance between population and resources, namely moral pressure (sexual restraint) or violent circumstances (famine or war). According to Ross, the decades after Malthus's … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif
Near real-time monitoring of HIV transmission hotspots from routine HIV genotyping: an implementation case study
Authors: Art F Y Poon, Réka Gustafson, Patricia Daly, Laura Zerr, S Ellen Demlow, Jason Wong, Conan K Woods, Robert S Hogg, Mel Krajden, David Moore, Perry Kendall, Julio S G Montaner, P Richard Harrigan
Journal: The Lancet HIV (2016)
TRENDS IN RIGHT VENTRICULAR DYSFUNCTION AND TRICUSPID REGURGITATION AFTER SINGLE VENTRICLE PALLIATION OF HYPOPLASTIC LEFT HEART SYNDROME AND THEIR DIFFERENTIAL IMPACT ON SURVIVAL
Authors: Travis J. Wilder, Eugene Blackstone, Jeevanantham Rajeswaran, Christopher Caldarone, Peter J. Gruber, Bahaaldin Alsoufi, Robert Jaquiss, Christo I. Tchervenkov, James Jaggers, Ming-Sing Si, Christopher Mascio, Christian Pizarro, David Overman, Edward Hickey
Journal: Journal of the American College of Cardiology (2015)
Abstract 1469: Mechanisms of oncostatin M (OSM)-mediated breast cancer metastasis to bone: Evidence for a role in osteoclastogenesis
Authors: Celeste M. Bolin, Ken Tawara, Caleb Sutherland, Robin Anderson, Cheryl Jorcyk
Journal: Cancer Research (2011)

Abstract Oncostatin M (OSM) is an interleukin-6 (IL-6)-family cytokine that has been implicated in a number of biological processes including the induction of inflammation and modulation of the extracellular matrix. OSM was initially shown to inhibit the proliferation of breast cancer cell lines in vitro and has been evaluated as a potential cancer therapy. However, evidence in the literature and our data suggest that OSM may actually promote tumor invasion and metastasis. Using the orthotopic 4T1.2 mouse mammary model of metastasis, we have investigated the ability of OSM to enhance the formation of metastases in organs such as lung and bone in vivo. OSM expression was knocked down using shRNA in 4T1.2 cells, which endogenously express both OSM and its receptor. These 4T1.2-OSM cells were orthotopically injected into Balb/c mice and resulted in a 98% decrease in metastasis to bone and a 55% decrease in metastasis to lung compared to that of 4T1.2-Lac Z control cells. Metastases were quantified using qPCR to detect the vector neomycin resistance gene in post-mortem organ samples. In this study we investigate the specific cellular mechanisms that might be important for tumor cell-derived OSM promotion of metastasis to bone, such as hypoxia-inducible factor 1 alpha (HIF1α) and vascular endothelial growth factor (VEGF). An in vitro model was developed using the pre-osteoclast cell line (RAW 264.7) co-cultured with 4T1.2 mouse mammary tumor cells treated with and without recombinant OSM. Osteoclastogenesis of co-cultured RAW 264.7 cells was measured by staining for differentiated osteoclasts using the TRAP (tartrate-resistant acid phosphatase) assay and was found to increase with OSM treatment. Additionally, suppression of HIF1α expression by siRNA resulted in a 76% decrease in OSM-induced osteoclastogenesis. As RAW 264.7 cells do not express the OSM receptor beta (OSMRβ) necessary for OSM signaling, we suggest that this inhibition of osteoclast differentiation is via an autocrine signaling mechanism in the 4T1.2 cells that initiates the secretion of osteoclast differentiation factors including VEGF. Currently, we are investigating what these secreted factors from 4T1.2 cells are that affect RAW 264.7 cell differentiation and activity. Our results suggest that OSM might be an important therapeutic target in the prevention of metastatic breast cancer invasion of bone. Funded by ACS RSG-09-276-01-CSM, Susan G Komen for the Cure KG100513, and NIH/NCRR P20RR016454. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1469. doi:10.1158/1538-7445.AM2011-1469
Case 21-2014
Authors: Nagagopal Venna, John L. Niles, Michael H. Lev, Matthew P. Frosch
Journal: New England Journal of Medicine (2014)

A 68-year-old man with a history of granulomatosis with polyangiitis was admitted to this hospital because of diplopia of 2 days' duration. On examination, there was left facial weakness and ptosis.
Abstract P6-14-13: A Flavone from Traditional East Asian Natural Extract Inhibits STAT3 and Tumor Growth in a Syngeneic Mouse Breast Cancer Model
Authors: M Senthil, YM Akmal, Q Xing, J Yan, JH. Yim
Journal: Cancer Research (2010)

Abstract Background: Recent studies have shown that increased dietary consumption of flavones and isoflavones is associated with reduced risk of developing cancer. Natural plants/herbs used in Traditional East Asian Medicine (TEAM) have been recognized as potentially efficacious natural treatments against cancer and are enriched with isoflavones and flavones, as well as other interesting compounds. We used a novel high throughput screening method to identify natural extracts that may have a potential anti-cancer effect and identified the TEAM natural product Scutellaria baicalensis and a known active component, the flavone, baicalein. The objective of our current study is to investigate the anti-cancer effects of baicalein in vitro and in vivo. Methods: In vitro testing was performed in mouse (C3L5) and human (SKBR3) breast cancer cell lines. Cell viability was assessed by MTT assay. Apoptosis was assessed using FITC-Annexin V and PI staining with bivariate reading by flow cytometry at 48 h. A syngeneic mouse breast cancer model (C3H/HeJ — C3L5) was used for in vivo testing. Mice bearing subcutaneous tumors were either treated with daily intraperitoneal injection of vehicle or baicalein (20 mg/kg) five days a week for three weeks (n=6/group). Tumor size and weights were measured. Results: Baicalein had a marked cytotoxic effect in C3L5 cells with an IC50 of less than 10mM (data not shown). FITC-Annexin V and PI analysis with flow cytometry for C3L5 cells treated at 10μM for 48h showed a marked increase in the Annexin V positive fraction indicative of apoptosis. In vivo studies demonstrated a significantly decreased tumor growth in mice treated with intraperitoneal baicalein when compared to the control group (P&amp;lt;0.05). Baicalein treated cells demonstrated STAT3 inhibition on western blot analysis by decreased presence of phospho-STAT3 (data not shown). Conclusions: Baicalein, a flavone from TEAM demonstrates significant anti-cancer effects due to apoptosis in breast cancer. STAT3, a well-known anti-apoptotic signaling intermediate, is inhibited in activation as reflected by decreased phosphoSTAT3 which may account for these effects. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-14-13.
RESULTADOS DEL TRATAMIENTO ENDOSCÓPICO DE LA DISRUPCIÓN NO TRAUMÁTICA DEL WIRSUNG
Authors: JJ Vila, M Gómez, M Basterra, M Kutz, F Bolado, J Urman, C Prieto, O Nantes, I Fernández-Urién, FJ Jiménez
Journal: Endoscopy (2011)

Introducción: La disrupción del Wirsung (DW) tras pancreatitis severa ocurre en el 37% de los casos. El tratamiento endoscópico consigue la curación en el 55–100% con 7% complicaciones.