Moderate Alcohol Intake and Cardiometabolic Risk in Adults With Type 2 Diabetes
Authors: Douglas G. Altman
Journal: Annals of Internal Medicine (2016)

Letters5 July 2016Moderate Alcohol Intake and Cardiometabolic Risk in Adults With Type 2 DiabetesDouglas G. Altman, DScDouglas G. Altman, DScFrom Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-5013 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read Gepner and colleagues' article (1) with interest. In their most common form, randomized trials compare groups of persons receiving different interventions that are studied simultaneously. Each participant receives 1 intervention selected at random at enrollment. The probabilities of being allocated to each treatment are usually equal (for example, an allocation ratio of 1:1). That all participants have the same probability of receiving each treatment is implied. That principle is violated if the allocation ratio is changed (for example, from 1:1 to 1:2) partway through the trial. Although all participants are randomly assigned to 1 of ...References1. Gepner Y, Golan R, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Shelef I, et al. Effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type 2 diabetes: a 2-year randomized, controlled trial. Ann Intern Med. 2015;163:569-79. [PMID: 26458258]. doi:10.7326/M14-1650 LinkGoogle Scholar2. Armitage P, Borchgrevink CF. Prevention of recurrences of myocardial infarction. Comments on a previous article. Arch Intern Med. 1966;118:270-4. [PMID: 5947307] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Centre for Statistics in Medicine, University of Oxford, Oxford, United Kingdom.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L16-0013. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes Yftach Gepner , Rachel Golan , Ilana Harman-Boehm , Yaakov Henkin , Dan Schwarzfuchs , Ilan Shelef , Ronen Durst , Julia Kovsan , Arkady Bolotin , Eran Leitersdorf , Shoshana Shpitzen , Shai Balag , Elad Shemesh , Shula Witkow , Osnat Tangi-Rosental , Yoash Chassidim , Idit F. Liberty , Benjamin Sarusi , Sivan Ben-Avraham , Anders Helander , Uta Ceglarek , Michael Stumvoll , Matthias Blüher , Joachim Thiery , Assaf Rudich , Meir J. Stampfer , and Iris Shai Moderate Alcohol Intake and Cardiometabolic Risk in Adults With Type 2 Diabetes Alain Braillon Moderate Alcohol Intake and Cardiometabolic Risk in Adults With Type 2 Diabetes Richard Saitz and Timothy Naimi Moderate Alcohol Intake and Cardiometabolic Risk in Adults With Type 2 Diabetes Richard Saitz and Timothy Naimi Moderate Alcohol Intake and Cardiometabolic Risk in Adults With Type 2 Diabetes Alain Braillon Metrics Cited byAvoiding bias in trials in which allocation ratio is varied 5 July 2016Volume 165, Issue 1Page: 67-68KeywordsAlcoholsConflicts of interestDisclosureRandomized trialsType 2 diabetesWine ePublished: 5 July 2016 Issue Published: 5 July 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...