tbuckley/cabot-search huggingface dataset:
P1-07-22: A Venezuelan Study of Breast Cancer Estrogen Receptor, Progesterone Receptor and HER2 Receptor Expression by the Standard Method, Immunohistochemistry (IHC), Compared to a New Method, Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR).
Authors: C-EM Marin, AC Ramirez, FL Baehner, C Yoshizawa, MM Acosta
Journal: Cancer Research (2011)

Abstract Background: Assessment of ER, PR and HER2 is of significant importance in breast cancer diagnosis and treatment. We have performed the first large assessment of central IHC for ER, PR and HER2 by a South American (Caracas, Venezuela) Central Lab to Central Lab RT-PCR by Oncotype DX®. Design: Breast cancer specimens from the Fundación BADAN were evaluated by IHC for ER (clone 1D5), PR (clone 636) using 1% staining for positivity using ASCO/CAP guidelines and HER2 (clone A0485) using ASCO/CAP guidelines of 3+ in ≥30%. Standardized quantitative RT-PCR analysis for ER and PR used Oncotype DX with the pre-defined cutoffs of 6.5 units and 5.5 units for positivity, respectively. For HER2 the standard pre-defined cutoffs were used: positive ≥11.5 units, equivocal &amp;gt;10.7-&amp;lt;11.5 units, and negative ≥10.7 units. For HER2 concordance analysis the equivocal range was excluded from both assays according to ASCO/CAP Guidelines (Wolff et al, 2006). For all quantitative RT-PCR assessments the reference normalized expression measurements ranged from 0 to 15, where each 1-unit increase reflects about a 2-fold increase in RNA. Result: Evaluable data was obtained in 96 pts for ER, 95 pts for PR (1 patient assessment unavailable) and 89 pts for HER2 (7 patient assessments unavailable). Two-by-two tables (below) compare IHC versus RT-PCR for ER, PR and HER2. The overall concordance for ER between IHC and RT-PCR was 94% (Kappa 0.467; 95% CI 0.107, 0.828); for PR between IHC and RT-PCR was 92% (Kappa 0.668; 95% CI 0.457, 0.878); and for HER2 between IHC and RT-PCR was 97% (Kappa = 0.649; 95% CI 0.280, 1.000). Three IHC 2+ cases and 4 equivocal cases by Oncotype DX were excluded from Concordance and Kappa statistics. Conclusion: RT-PCR by Oncotype DX for ER, PR and HER2 status is useful for active monitoring of IHC assays as mandated by ASCO/CAP guidelines. There is a high degree of overall concordance between central IHC performed in South America (Caracas, Venezuela) and central RT-PCR for ER, PR and HER2 status. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P1-07-22.
FRI0143 The Effectiveness of Educational Programs for Patients with Early Ankylosing Spondylitis in Clinical Practice
Authors: S. Lapshina, L. Myasoutova, R. Abdrakipov, R. Mukhina, M. Sadykov
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Effective and long-term therapy of ankylosing spondylitis (AS) is not possible without the active participation of the patient in this process, which requires educational programs. <h3>Objectives</h3> To evaluate the effectiveness of educational activities for patients with early AS. <h3>Methods</h3> Main group: 25 patients with a documented AS, disease duration less than 5 years and ra diological stage no more than 2, were trained in schools for patients 4 times (2 in the first month and 2 every 2 months). The issues of the importance of regular exercises, physical therapy, continuous administration of non-steroidal anti-inflammatory drugs (NSAIDs), the need for monitoring at the rheumatologist were discussed. Control group: 25 patients received information about their disease only during rheumatologist consultation. The groups were matched for sex, age, duration of symptoms, disease activity, appointed drug therapy. At baseline and after 6 months BASDAI, ASDAS, BASFI, WPAI, regularity of exercises and commitment to treatment were determined. <h3>Results</h3> After 6 months of the training BASDAI decreased by 2,9±0,2 points in the main group and 1,6±0,3 points in the control group (p&lt;0,05), BASFI at 1,9±0,3 score - main group, 1,01±0,3 control group (p&lt;0,05), ASDAS decreased by 1,91±0,35 in the group trained and 123±0,26 in the control group (p&lt;0,05). After 6 months, 80% patients achieved improvement criteria ASAS40, 44% patients - partial remission (main group) against 48.0% and 14% respectively in the control, p&lt;0.05. After 6 months, the proportion of patients, who regularly perform physical exercises in the study group increased by 4 times and amounted to 84% of patients, in the control group - 2 times and amounted to 44%. In the study group 76% of the patients constantly used NSAIDs, regardless of pain, in the control group 36% of patients received NSAIDs on request only. WPAI was 32.4% at baseline in training patients, after 6 months - 20.6%, in the control group - 30.4% at baseline and 25.8% at 6 months, respectively. Dynamics in patients who have received training was more important, which determined to significant differences between groups for most indicators (p&lt;0.05). <h3>Conclusions</h3> Educational program for patients with early AS, increases compliance to treatment and contributes to a better implementation of the recommendations of the doctor, which helps to control disease activity, to achieve remission, improves functional status and performance of patients with AS. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5558
Mechatronic concept of a semiautonomous instrument changing system for flexible NOTES platforms
Authors: A Fiolka, G Horst, H Ulbrich, A Schneider, H Feussner
Journal: Endoscopy (2012)

Objective: NOTES mechatronic support systems are still needed to overcome the well-known problems of the new technique. New developments will be established only if they are adapted to the clinical workflow. Therefore it is important that tasks of the assistant and of the physicians are equally considered. Changing of flexible instruments is a task that is mostly carried out by the assistant. Because of the flexible design and the length of the manipulators the handling is quite difficult. Instruments can be contaminated by carelessness during the insertion into the working channel and changing is a time consuming task which should be facilitated. We describe a mechanical instrument changing system to standardize, and to accelerate this process and to reduce the workload of the staff.
TRANSCATHETER AORTIC VALVE IMPLANTATION IN PATIENTS WITH CONCOMITANT MITRAL OR TRICUSPID REGURGITATION
Authors: Maria I. Drakopoulou, Konstantinos Toutouzas, Archontoula Michelongona, Konstantinos Stathogiannis, George Latsios, Andreas Synetos, George Peskesis, Constadina Aggeli, Eleftherios Tsiamis, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2016)
Smoking Control Effort Moves to Second Phase
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Smoking Control Effort Moves to Second Phase Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 21, 3 November 1993, Pages 1720–1721, https://doi.org/10.1093/jnci/85.21.1720 Published: 03 November 1993
SAT0466 The “table-1 P value” issue; baseline group comparison is inappropriately omitted in non-randomized studies
Authors: K. Tascilar, E. Atac, F. Esen, H. Yazici
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Guidelines on reporting randomized controlled trials advise against performing baseline comparison in randomized groups (1). Such comparison is considered futile as any difference will be by chance by definition (2). In non-randomized studies, on the contrary, the baseline characteristics of the study groups should be compared because the differences may have direct implications on the results. <h3>Objectives</h3> The aim of this study was to determine the frequency of inappropriate commission or omission of baseline comparisons in randomized and non-randomized studies, respectively. <h3>Methods</h3> A PubMed search was conducted to identify clinical studies among humans, designed to test the effect of a treatment or an observation in more than one group in 3 major rheumatology journals; Annals of the Rheumatic Diseases, Arthritis and Rheumatism and Rheumatology (Oxford) from June 2010 to June 2011. Studies were grouped as either randomized or non-randomized. We evaluated each study as to how the baseline characteristics were presented. Also the frequencies of inappropriate commission or omission of statistical comparisons were tabulated. <h3>Results</h3> 205 studies were found, 107 were included. There were 60 randomized trials and 47 non-randomized studies. Among the randomized studies, 6/60 (10%) reported inappropriate baseline statistical comparisons. On the other hand among the non-randomized studies, 27/47 (57%) omitted baseline statistical comparison. In 10 of these 27 studies, there was no table presenting the characteristics of the groups subject to comparison. 17 studies on the other hand presented baseline groups in a table 1 but did no statistical comparisons although necessary. <h3>Conclusions</h3> The CONSORT statement seems to be better adhered to when reporting randomized controlled trials. On the other hand there is common and inappropriate omission of the necessary statistical comparisons at baseline in non-randomized studies. In this line there’s an obvious need to improve adherence to the TREND statement (3). <h3>References</h3> J Pharmacol Pharmacother. 2010;1:100-7. Lett Ed Rheumatol 1:e110002. doi:10.2399/ler.11.0002. Am J Public Health. 2004; 94: 361–366. <h3>Disclosure of Interest</h3> None Declared
Case 31-2011
Authors: Michael Lanuti, Lecia V. Sequist, Amita Sharma, Mari Mino-Kenudson
Journal: New England Journal of Medicine (2011)

A 55-year-old man was seen at this hospital because of headaches, weakness of the left side of the body, and a mass in the brain. Chest CT showed a mass in the right lower lobe of the lung; biopsy revealed adenocarcinoma. Additional diagnostic testing was performed.
Endoscopic Submucosal Resection with Double Ligation Technique for Treatment of Small Rectal Carcinoid Tumors
Authors: J. Moon, J. Kim, C. Park, J. Jung, W. Shin, J. Kim, K. Kim, T. Hahn, K.-S. Yoo, S. Park, C. Park
Journal: Endoscopy (2006)

It is difficult to achieve complete endoscopic resection of rectal carcinoid tumors without any procedure-related complications. In this study, we evaluated the efficacy and safety of endoscopic submucosal resection with double ligation (ESMR-DL) for the treatment of small rectal carcinoid tumors.Eleven rectal carcinoid tumors (in 11 patients) were resected by ESMR-DL between November 2001 and April 2004, using a conventional single-channel endoscope with an attached band-ligator device. The lesion was aspirated into the ligator device and an elastic band was placed around the base; a detachable snare was then used to ligate the stalk below the elastic band; and snare resection was performed above the elastic band. The resected specimens were examined with respect to size, histological atypia, depth of invasion, and the histological appearance of the resection margins.All the lesions were excised completely without any complications. There was no tumor invasion beyond the submucosal layer and there was no evidence of atypia in any of the specimens. Tumor diameter varied from 2.0 mm to 10.0 mm (average 6.2 mm). None of the 11 specimens showed histopathological evidence of tumor involvement at the resection margins. There were no immediate or late complications (bleeding or perforation) after ESMR-DL. There was no local recurrence and there were no distant metastases in any patients during the mean follow-up period of 18 months.Endoscopic submucosal resection with double ligation is a useful and safe method for the treatment of small rectal carcinoid tumors.
PTH-026 Evaluation Of A Service To Manage Inflammatory Bowel Disease (ibd) In Pregnancy
Authors: C Parker, M Gunn
Journal: Gut (2014)

<h3>Introduction</h3> Following the publication of a consensus for management of IBD in pregnancy a service was set up in our institution (April 2013) to optimise the management of pregnant women with IBD. Its’ aim is to enable multidisciplinary management of patients with a consultant gastroenterologist, consultant obstetrician, colorectal surgeon and IBD specialist nurse. It provides a baseline health check in the early stages of pregnancy, more intensive foetal growth monitoring with additional growth scans at 28 and 32 weeks of pregnancy, discussion of delivery methods and anticipation of potential peripartum problems including liaison with colorectal surgical team. A review of the service was performed after 8 months to provide an overview of management of patients, demand and outcomes following set up of the service. <h3>Methods</h3> A retrospective review of medical notes was performed of patients seen in the clinic. Information was gathered on diagnosis, previous surgery for IBD, parity, outcomes of previous pregnancies, medication preconception and during pregnancy, disease activity preconception and during pregnancy and outcome of pregnancy. <h3>Results</h3> Data was collected on 20 patients. 8 had Crohns disease (CD), 12 had ulcerative colitis (UC). Surgery: In the UC group 3/12 had previous surgery:2 ileoanal pouch, 1 subtotal colectomy. In CD group 4/8 had an ileocolonic resection. Parity: 5=para 1, 8=para 2, 6=para 3, 1=para 4. Medication: 11/20 were on no medication (6 UC, 5 CD). 3 were on infliximab, last infusion 20/40, 3 were on azathioprine, 5 were on a 5ASA. Disease activity: 19/20 were well preconception, 1 was unwell around time of conception (miscarriage at 11/40). 10/20 had a flare of disease activity during pregnancy: 1 settled with topical treatment, 1 settled with 5ASA, 8 required oral steroids. All 3 patients on infliximab had a flare after stopping it and required oral steroids. 1 of these had a stillbirth shortly after commencing steroids for a flare. Outcomes: 10/20 have not yet delivered, 3 are planned for elective CS (1 perianal disease, 1 previous CS, 1 previous forceps delivery). 3 had CS (2 had ileoanal pouches and 1 had perianal disease), 1 stillbirth, 1 miscarriage, 5 had normal vaginal delivery (NVD). No preterm births or low birth weights reported. <h3>Conclusion</h3> Those with ileoanal pouches and perianal disease are being appropriately considered for a planned CS. 50% of our patients have a NVD which as expected is lower than the general population. 50% of our patients had a flare in disease during pregnancy which is higher than literature (30%)<sup>1. </sup>80% required oral prednisolone to settle and both adverse outcomes appear to be related to a flare in disease. Those on infliximab appear to be at high risk of flaring after their last dose around 20 weeks. <h3>Reference</h3> 1 Janneke van der Woude <i>et al</i>. J Crohns Colitis 2010:4:493–510 <h3>Disclosure of Interest</h3> None Declared.
Recent Advances in the Care of the Surgical Complications of Diabetes Mellitus
Authors: Leland S. McKittrick
Journal: New England Journal of Medicine (1946)

MUCH has already been written on the factors involved in the care of the surgical complications of patients with diabetes mellitus. The purpose of this paper is not to review the entire problem but rather to consider the effects of many recent advances in medical science on the care of these patients. I shall confine my remarks to the consideration of the surgical problems.It is difficult to evaluate the factors that have improved the care of poor-risk and elderly patients in recent years. The security of all patients undergoing surgical procedures has been aided immeasurably by more careful and . . .
517 EFFECTIVENESS AND SAFETY OF BACLOFEN TREATMENT IN ALCOHOL-DEPENDENT PATIENTS WITH OR WITHOUT LIVER CIRRHOSIS: RESULTS OF AN OPEN STUDY IN TRUE LIFE
Authors: C. Barrault, H. Lison, E. Sarlon, M. Cordonnier, I. Rosa, D. Belloula, G. Pulwermacher, H. Hagège, J.-F. Cadranel
Journal: Journal of Hepatology (2013)
Case 9-2014
Authors: Kai Saukkonen, Timothy C. Tan, Amita Sharma, Richard N. Channick, Mandakolathur R. Murali, Lawrence R. Zukerberg
Journal: New England Journal of Medicine (2014)

A 34-year-old woman with a history of Raynaud's phenomenon and symmetric joint pain was admitted to the hospital because of increasing dyspnea. An echocardiogram showed severe pulmonary hypertension. Diagnostic test results were received.
BRL 43694: A Novel Antiemetic to Prevent Nausea and Vomiting Induced by Chemotherapy
Authors: R. A. JOSS, J. RICHNER, K. W. BRUNNER, D. ROHRBACH, M. PIROVINO, J.-P. TERREY, J. UPWARD
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article BRL 43694: A Novel Antiemetic to Prevent Nausea and Vomiting Induced by Chemotherapy Get access RUDOLPH A. JOSS, RUDOLPH A. JOSS Division of Medical Oncology, Department of Internal Medicine, KantonsspitalCH-6004 Lucerne, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar JÜRG RICHNER, JÜRG RICHNER Institute for Medical Oncology, University of Bern, InselspitalCH-3010 Bern, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar KURT W. BRUNNER, KURT W. BRUNNER Institute for Medical Oncology, University of Bern, InselspitalCH-3010 Bern, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar DANIELA ROHRBACH, DANIELA ROHRBACH Department of Medicine, University of Bern, InselspitalCH-3010 Bern, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar MAURO PIROVINO, MAURO PIROVINO Department of Medicine, University of Bern, InselspitalCH-3010 Bern, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar JEAN-PIERRE TERREY, JEAN-PIERRE TERREY Beecham Pharmaceuticals Research Division HarlowEssex, England Search for other works by this author on: Oxford Academic PubMed Google Scholar JAMES UPWARD JAMES UPWARD Beecham Pharmaceuticals Research Division HarlowEssex, England Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 16, 19 October 1988, Pages 1340–1341, https://doi.org/10.1093/jnci/80.16.1340 Published: 19 October 1988
THE EFFECT ON LESION CONTRAST EFFECTS OF A SCANNING LINE SOURCE ATTENUATION CORRECTION METHOD
Authors: M. W. Groch, S. M. Spies, J. Zadlo, W. D. Erwin, P. J. Groch
Journal: Clinical Nuclear Medicine (1997)

Scientific Abstracts: Central Chapter, Society Of Nuclear Medicine Meeting, April 11-13, 1997, Grand Geneva Resort, Lake Geneva, Wi
1147 VIROLOGICAL RESPONSE AND RELAPSE RATES IN FRENCH CHC PATIENTS TREATED WITH PEGINTERFERON ALFA-2A/RIBAVIRIN: A SUB-ANALYSIS OF THE FINAL POPULATION FROM THE PROPHESYS STUDY
Authors: D. Ouzan, D. Larrey, F. Habersetzer, A.-J. Remy, J.-M. Combis, G. Riachi, D. Lucidarme, V. Leroy, T. Constant, M. Schmitz, V. Cartier, P. Marcellin
Journal: Journal of Hepatology (2012)
Lack of TLR4 on bone marrow derived cells ameliorates experimental arthritis and decreases cd4<sup>-</sup>IL-17<sup>+</sup>cells
Authors: Ben T van den Brand, Shahla Abdollahi-Roodsaz, Miranda B Bennink, Onno J Arntz, Wim B van den Berg, Fons A van de Loo
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background and objectives</h3> The IL-1 receptor antagonist knockout mice (IL-1Ra<sup>-/-</sup>) spontaneously develop a T cell driven arthritis with profound IL-17 production. When cross bred with TLR4 knock out (TLR4<sup>-/-</sup>) these animals showed reduced inflammation, joint destruction, and diminished IL-17 levels.1 Here, the authors set out to determine the role TLR4 on bone marrow derived cells in experimental arthritis. <h3>Materials and methods</h3> An age-matched, sex-mismatched reciprocal bone marrow transplantation was performed with TLR4<sup>-/-</sup> and TLR4<sup>+/+</sup> mice in the IL-1Ra-/- background. Reconstitution was assessed by staining bone marrow cells for Y-chromosome and peritoneal macrophages were stimulated with lipopolysaccharide (LPS). Clinical manifestation of disease was monitored macroscopically (0–2 per joint). Joint pathology and inflammation were scored on Safranin-O and haematoxylin/eosin stained sections (0–5). T cell analysis was performed on cells from draining lymph nodes using flow cytometry. <h3>Results</h3> Reconstitution of bone marrow was successful as determined by Y-chromosome staining. Peritoneal macrophages from animals engrafted with TLR4+/+ bone marrow showed normal IL-6 mRNA up regulation after LPS challenge, whereas IL-6 mRNA up regulation was significantly reduced by 90% in animals that received TLR4-/- bone marrow. Arthritis incidence was not affected by TLR4 deficiency and ranged between 50 and 87% in all bone marrow chimeras. However, animals that lacked TLR4 on the engrafted bone marrow cells, radio-resistant cells, or both showed 38 to 44% reduced arthritis score compared to animals expressing TLR4 on all cells. This decrease also reflected in bone erosion and cartilage scores of the joints, which were diminished in animals partially or complete TLR4 deficient. Cell analysis of draining lymph nodes showed reduced percentage of IL-17+ cells. Strikingly, no differences were found in Th17 (CD4+IL-17+) levels, but in the CD4-IL-17+ population. When TLR4 was lacking on bone marrow cells the percentage of CD4- IL-17+ cells was reduced by 50%. Further analysis in IL-1Ra-/- mice showed that the CD4-IL-17+ cells in draining lymph nodes consisted for 80% of γδ T cells. Indicating these cells as main IL-17 producers in the IL-1Ra-/- arthritis model. <h3>Conclusions</h3> The role of TLR4 on bone marrow cells in experimental arthritis is promoting IL-17 production by CD4- cells, most likely γδ T cells, and thereby aggravating arthritis. TLR4 increases macrophage activation which leads to attraction of γδ T cells to the inflammation in the joint and subsequent IL-17 production at the inflammation site aggravating joint pathology.
268 MIR-155 IS AN INDUCER FOR THE INSULIN-LIKE GROWTH FACTOR II MITOGENIC SIGNALING PATHWAY IN HCV-PROGRESSED HEPATOCELLULAR CARCINOMA
Authors: H.M. El Tayebi, K.A. Hosny, G. Esmat, K. Breuhahn, A.I. Abdelaziz
Journal: Journal of Hepatology (2012)
SP0140 Prognosis and Outcome of Dermatomyositis in Children
Authors: A. Reed
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Childhood dermatomyositis, the most common inflammatory myopathy of childhood, is an autoimmune vasculopathy that is characterized by classic rashes and proximal muscle weakness. We have begun to make progress to understand the genetic contribution, importance of environmental exposures, local environmental milieu and need for early and effective treatments for both new onset and resistant disease. Even with these great strides we still have a great deal to learn about disease pathogenesis and how to better define disease prognosis and outcomes. In this discussion we will start by reviewing longitudinal cohort data which demonstrates potential disease complications and comorbidities followed by a review of the disease subsets and those clinical and biologic features that help determine disease course, involvement and response to treatment. In this context, we will review autoantibodies specificities related to disease subset, biomarkers of disease and the tissue specific changes that predict out come. <h3>Disclosure of Interest</h3> None Declared