tbuckley/cabot-search huggingface dataset:
PTH-016 Post colonoscopy colorectal cancer (pccrc) rates – a district general hospital experience
Authors: R Saleem, J Iqbal, M Vithayathil, ZA Sher, P Mairs
Journal: Gut (2015)

<h3>Introduction</h3> Colorectal cancer (CRC) is the second leading cause of cancer related deaths in the United Kingdom. Colonoscopy is recommended first line investigation for CRC. Most studies recommend counselling patients undergoing colonoscopy about a “miss rate” of up to 6%.<sup>1</sup>The aim of this retrospective study was to evaluate the frequency of post colonoscopy colorectal cancer (PCCRC) in a District General Hospital. <h3>Method</h3> Data for all patients with a new diagnosis of CRC were obtained from our local colorectal cancer services between Jan 2011 to Sept 2014. We identified all patients who have had colonoscopy within 36 months of a CRC diagnosis. PCCRC was defined as those who had colonoscopy within 6–36 months of diagnosis, whereas the cancers were classified as “detected” if diagnosis was made within 6 month of preceding colonoscopy. Patients with incomplete colonoscopy were excluded. <h3>Results</h3> 494 patients were diagnosed with CRC. Of these, 161 patients had a colonoscopy within 36 months preceding diagnosis. 2.5% (4/161) patients were found to have PCCRC. 75% were male and mean age of the patients was 77 years (range 61–86 years). Bowel preparation was reported to be good in all procedures. The location of the PCCRC was sigmoid (2), descending colon (1) and transverse colon (1). The indication for colonoscopy was anaemia (2), bleeding per rectum (1) and Crohn’s colitis surveillance (1). Only 1 colonoscopy detected colonic polyp, tubulovillous adenoma with high grade dysplasia; however this was not followed up as per guidelines. The mean time between colonoscopy and definitive colon cancer diagnosis was 30 months (range 19–36 months). All patients with PCCRC died with a mean survival time of 376 days from the time of cancer diagnosis. Two of these four patients had metastatic disease at the time of diagnosis with one of the patient had extensive metastasis and died within 16 days of diagnosis. <h3>Conclusion</h3> In our study, rate of PCCRC was 2.5%, although this rate is low compared to most studies<sup>2</sup>but it has serious implications and may lead to diagnosis at an advanced stage. It is prudent to audit the miss rate of colonoscopy to improve colonoscopy quality and the rate of PCCRC occurrence should be incorporated as a quality indicator of a colonoscopy service <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Bressler B, Paszat LF, Chen Z <i>et al</i>. Rates of new or missed colorectal cancers after colonoscopy and their risk factors: a population-based analysis. Gastroenterology 2007;132:96–102 Morris EJ, Rutter MD, Finan PJ <i>et al</i>. Post-colonoscopy colorectal cancer (PCCRC) rates vary considerably depending on the method used to calculate them: a retrospective observational population-based study of PCCRC in the English National Health Service. <i>Gut</i>2014. doi: 10.1136/gutjnl-2014-308362
Hypertension, the Swedish Patient Register, and Selection Bias—Reply
Authors: Casey Crump, Jan Sundquist, Kristina Sundquist
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
THU0214 Effect of TNF Inhibitors On Radiographic Progression of Sacroiliac Joints in Axial Spondyloarthrities Tunisian Patients
Authors: I. Mahmoud, K. Maatallah, O. Saidane, L. Metoui, W. Hamdi, R. Tekaya, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Spondyloarthities primarily manifest in the axial skeleton, with a majority of patients having manifestations in the sacroiliac (SI) joints. <h3>Objectives</h3> To assess the efficacy of TNF inhibitors in reducing sacroiliac (SI) joint progression in patients with Axial Spondyloarthities (AS) <h3>Methods</h3> AS patients (satisfying ASAS criteria 2009) with at least two sets of Antero-posterior X-rays of the pelvis at a minimum gap of 2 years were included and were divided into two groups: Group1: received TNF-inhibitors and group 2 received non-steroidal antiinflammatory and/or scDMARDs. Radiographic severity was assessed by Forrestier classification at beseline, at 2years and after an average of 5 years. Patients with grade 4 SI joints were excluded. Bath AS Disease Activity Index (BASDAI), BASFI, ESR, CRP, HLA-B27 and age of onset were included in the model <h3>Results</h3> Group 1 included 46 patients. The median age of onset of the disease was 25 years [16-49ans], HLA B27 was positive in 53% of cases. The median BASDAI and BASFI scores were respectively 5,8 and 5,4. The average ESR and CRP were respectively 49 and 35. Patients received Infliximab 48%, Adalimumab 14% and Etanercept 36%. Twenty two patients received csDMARDs and 24 NSAID. The mean SI joint grade at baseline was 3. Sixty four percent of patients had SI joint grade 3 and 36% had SI joint grade2. Group 2 included 38 patients. There were no significant differences between the two groups for the mean age of onset, the mean CRP and ESR level and SI joint grade at baseline, however BASDAI and BASFI scores at baseline were significantly higher in Group1. In the group of study 30% of patients with SI joint grade 3 progressed to grade 4 and 22% o of patients with SI joint grade2 progressed to grade 3.There were no significant difference between the two groups <h3>Conclusions</h3> TNF inhibitors do not seem to prevent radiographic progression of the sacroiliac joints. <h3>Disclosure of Interest</h3> None declared
Linkage disequilibrium between the CA microsatellite D16S283 and PKD1.
Authors: G D Wright, A E Hughes, K A Larkin, C C Doherty, N C Nevin
Journal: Journal of the American Society of Nephrology (1994)

Journal of the American Society of Nephrology : JASN 5(4):p 1159-1160, October 1994. | DOI: 10.1681/ASN.V541159
The legacy of Ewald Hecker: a new translation of "Die Hebephrenie". Translated by Marie-Louise Schoelly
Authors: M J Sedler
Journal: American Journal of Psychiatry (1985)

Early descriptions of schizophrenia may be found in the writings of Haslam and Morel, but the turning point in the development of the modern concept was Ewald Hecker's classic paper on hebephrenia in 1871. The syndrome he described--a psychosis of early onset with a deteriorating course characterized by a "silly" affect, behavioral peculiarities, and formal thought disorder--not only adumbrated Kraepelin's generic category of dementia praecox but quite specifically defined the later subtype of hebephrenic, or disorganized, schizophrenia as well. The present translation into English of Hecker's "Die Hebephrenie" makes accessible a crucial milestone in the history of modern psychiatry.
Effect of Adrenalectomy and of Desoxycorticosterone Acetate on the Formation of Liver Lesions in Rats Fed <italic>p</italic>-Dimethylaminoazobenzene
Authors: Alexander Symeonidis, Ambadas S. Mulay, Frederick H. Burgoyne
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Effect of Adrenalectomy and of Desoxycorticosterone Acetate on the Formation of Liver Lesions in Rats Fed p-Dimethylaminoazobenzene Get access Alexander Symeonidis, Alexander Symeonidis National Cancer Institute,4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ambadas S. Mulay, Ambadas S. Mulay National Cancer Institute,4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederick H. Burgoyne Frederick H. Burgoyne National Cancer Institute,4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 4, February 1954, Pages 805–817, https://doi.org/10.1093/jnci/14.4.805 Published: 01 February 1954 Article history Received: 27 March 1953 Published: 01 February 1954
Should We Treat for Subclinical Hypothyroidism?
Authors: Risa B. Burns, Carol K. Bates, Pamela Hartzband, Gerald W. Smetana
Journal: Annals of Internal Medicine (2016)

In May 2015, the U.S. Preventive Services Task Force issued a guideline on screening for thyroid disease that included a systematic evidence review and an update of its 2004 recommendations. The review assessed the effect of treating screen-detected subclinical thyroid dysfunction on health outcomes. It found adequate evidence that treating subclinical hypothyroidism does not provide clinically meaningful improvements in blood pressure, body mass index, bone mineral density, lipid levels, or quality-of-life measures. The review also concluded that evidence was inadequate to determine whether screening for thyroid dysfunction reduced cardiovascular disease or related morbidity and mortality. In separate guidelines, the American Association of Clinical Endocrinologists and American Thyroid Association advocated aggressive case-finding and recommended screening persons with certain clinical conditions or characteristics rather than the general population. These societies argue that subclinical hypothyroidism adversely affects cardiovascular outcomes and thus merits case-finding. Here, 2 experts discuss their perspectives on whether treating subclinical hypothyroidism reduces morbidity and mortality, whether there are harms of treatment, and how they would balance the benefits and harms of treatment both in general and for a specific patient.
Ambient Temperature and the Risk of Preterm Birth in Guangzhou, China (2001–2011)
Authors: Jian-Rong He, Yu Liu, Xiao-Yan Xia, Wen-Jun Ma, Hua-Liang Lin, Hai-Dong Kan, Jin-Hua Lu, Qiong Feng, Wei-Jian Mo, Ping Wang, Hui-Min Xia, Xiu Qiu, Louis J. Muglia
Journal: Environmental Health Perspectives (2015)

Although effects of weather changes on human health have been widely reported, there is limited information regarding effects on pregnant women in developing countries.We investigated the association between maternal exposure to ambient temperature and the risk of preterm birth (< 37 weeks of gestation) in Guangzhou, China.We used a Cox proportional hazards model to estimate associations between preterm birth and average temperature during each week of gestation, with weekly temperature modeled as a time-varying exposure during four time windows: 1 week (the last week of the pregnancy), 4 weeks (the last 4 weeks of the pregnancy), late pregnancy (gestational week 20 onward), and the entire pregnancy. Information on singleton vaginal birth between 2001 and 2011 was collected. Daily meteorological data during the same period were obtained from the Guangzhou Meteorological Bureau.A total of 838,146 singleton vaginal births were included, among which 47,209 (5.6%) were preterm births. High mean temperatures during the 4 weeks, late pregnancy, and the entire pregnancy time windows were associated with an increased risk of preterm birth. Compared with the median temperature (24.4°C), weekly exposures during the last 4 weeks of the pregnancy to extreme cold (7.6°C, the 1st percentile) and extreme heat (31.9°C, the 99th percentile) were associated with 17.9% (95% CI: 10.2, 26.2%) and 10.0% (95% CI: 2.9, 17.6%) increased risks of preterm birth, respectively. The association between extreme heat and preterm birth was stronger for preterm births during weeks 20-31 and 32-34 than those during weeks 35-36.These findings might have important implications in preventing preterm birth in Guangzhou as well as other areas with similar weather conditions.He JR, Liu Y, Xia XY, Ma WJ, Lin HL, Kan HD, Lu JH, Feng Q, Mo WJ, Wang P, Xia HM, Qiu X, Muglia LJ. 2016. Ambient temperature and the risk of preterm birth in Guangzhou, China (2001-2011). Environ Health Perspect 124:1100-1106; http://dx.doi.org/10.1289/ehp.1509778.
Pituitary-Gonadal Function in Schoolboys with Varicocele and Indications of Varicocelectomy
Authors: Hiroaki Itatani, Takao Sonoda, Toshihiro Aono, Shigeru Mitsubayashi, Takao Yoshida, Mitsuo Miyagawa, Akihiko Okuyama, Takuo Koide
Journal: European Urology (1981)
SP0238 How Can Quality Indicators be used to Assess or Monitor Quality of Care?
Authors: L. Li
Journal: Annals of the Rheumatic Diseases (2015)

Quality indicators (QIs) are evidence-based tools that define the minimum standard of care patients should receive for a health condition. The objective of this presentation is to discuss the use of QIs to assess the quality of non-pharmacological care received by people with knee/hip osteoarthritis (OA) in the community. We conducted a postal survey to evaluate four Arthritis Foundation quality indicators for knee/hip OA: 1) advice to exercise, 2) advice to lose weight, 3) assessment for ambulatory function, and 4) assessment for non-ambulatory function. Eligible participants were identified from the administrative database of British Columbia, Canada between 1992 and 2006. 1,349 participants reported knee and/or hip OA [knee (51.9%); hip (19.3%); knee and hip=388 (28.8%)]. The overall pass rate of the four quality indicators was 22.4% (95% CI=20.5, 24.3). The pass rate for the individual quality indicator ranged from 6.9% for assessment of non-ambulatory function to 29.2% for receiving assessment of ambulatory function. Receiving exercise advice was associated with having a university degree (versus high school diploma; OR=3.10, 95% CI=2.00, 4.80). Receiving weight-loss advice was associated with being female (OR=2.64, 95% CI=1.71, 4.08), being aged 55–64 years (compared to being aged 75 and over; OR=1.96, 95% CI=1.02, 3.76), and having higher WOMAC scores (for every 10-point increment; OR=1.14, 95% CI=1.02, 1.26). On the other hand, having less than high school education reduced the odds of weight-loss advice (OR=0.52, 95% CI=0.30, 0.88). We concluded that the quality of non-pharmacological care for people with knee/hip OA in the community was suboptimal. In particular, advice on exercise and weight management might not be provided equally across sex, age, disability and formal education levels. The presentation will conclude by introducing a new initiative led by Dr. Marie Westby to develop QIs on total hip/knee arthroplasty rehabilitation for monitoring quality of care and guiding clinical practice in Canada. <h3>Disclosure of Interest</h3> None declared
Corneal and lenticular opacities in mentally retarded young adults treated with thioridazine and chlorpromazine
Authors: C T Gualtieri, W H Lefler, M Guimond, J I Staye
Journal: American Journal of Psychiatry (1982)

Of 18 mentally retarded institutionalized subjects who had received long-term, high-dose treatment primarily with thioridazine or chlorpromazine, 2 developed definite corneal and lenticular opacities and 2 had equivocal ocular changes. In view of this finding, the authors suggest that alternative treatment, including different neuroleptics, be considered with mentally retarded institutionalized subjects; when that is not possible, subjects should be given periodic evaluation, including annual slit-lamp examination.
3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering
Authors: Andrew C. Daly, Gráinne M. Cunniffe, Binulal N. Sathy, Oju Jeon, Eben Alsberg, Daniel J. Kelly
Journal: Advanced Healthcare Materials (2016)

The ability to print defined patterns of cells and extracellular-matrix components in three dimensions has enabled the engineering of simple biological tissues; however, bioprinting functional solid organs is beyond the capabilities of current biofabrication technologies. An alternative approach would be to bioprint the developmental precursor to an adult organ, using this engineered rudiment as a template for subsequent organogenesis in vivo. This study demonstrates that developmentally inspired hypertrophic cartilage templates can be engineered in vitro using stem cells within a supporting gamma-irradiated alginate bioink incorporating Arg-Gly-Asp adhesion peptides. Furthermore, these soft tissue templates can be reinforced with a network of printed polycaprolactone fibers, resulting in a ≈350 fold increase in construct compressive modulus providing the necessary stiffness to implant such immature cartilaginous rudiments into load bearing locations. As a proof-of-principal, multiple-tool biofabrication is used to engineer a mechanically reinforced cartilaginous template mimicking the geometry of a vertebral body, which in vivo supported the development of a vascularized bone organ containing trabecular-like endochondral bone with a supporting marrow structure. Such developmental engineering approaches could be applied to the biofabrication of other solid organs by bioprinting precursors that have the capacity to mature into their adult counterparts over time in vivo.
The Genetic Basis for Variation in Sensitivity to Lead Toxicity in <i>Drosophila melanogaster</i>
Authors: Shanshan Zhou, Tatiana V. Morozova, Yasmeen N. Hussain, Sarah E. Luoma, Lenovia McCoy, Akihiko Yamamoto, Trudy F.C. Mackay, Robert R.H. Anholt
Journal: Environmental Health Perspectives (2016)

Lead toxicity presents a worldwide health problem, especially due to its adverse effects on cognitive development in children. However, identifying genes that give rise to individual variation in susceptibility to lead toxicity is challenging in human populations.Our goal was to use Drosophila melanogaster to identify evolutionarily conserved candidate genes associated with individual variation in susceptibility to lead exposure.To identify candidate genes associated with variation in susceptibility to lead toxicity, we measured effects of lead exposure on development time, viability and adult activity in the Drosophila melanogaster Genetic Reference Panel (DGRP) and performed genome-wide association analyses to identify candidate genes. We used mutants to assess functional causality of candidate genes and constructed a genetic network associated with variation in sensitivity to lead exposure, on which we could superimpose human orthologs.We found substantial heritabilities for all three traits and identified candidate genes associated with variation in susceptibility to lead exposure for each phenotype. The genetic architectures that determine variation in sensitivity to lead exposure are highly polygenic. Gene ontology and network analyses showed enrichment of genes associated with early development and function of the nervous system.Drosophila melanogaster presents an advantageous model to study the genetic underpinnings of variation in susceptibility to lead toxicity. Evolutionary conservation of cellular pathways that respond to toxic exposure allows predictions regarding orthologous genes and pathways across phyla. Thus, studies in the D. melanogaster model system can identify candidate susceptibility genes to guide subsequent studies in human populations.Zhou S, Morozova TV, Hussain YN, Luoma SE, McCoy L, Yamamoto A, Mackay TF, Anholt RR. 2016. The genetic basis for variation in sensitivity to lead toxicity in Drosophila melanogaster. Environ Health Perspect 124:1062-1070; http://dx.doi.org/10.1289/ehp.1510513.
A Triboelectric‐Based Artificial Basilar Membrane to Mimic Cochlear Tonotopy
Authors: Jongmoon Jang, JangWoo Lee, Jeong Hun Jang, Hongsoo Choi
Journal: Advanced Healthcare Materials (2016)

A triboelectric-based artificial basilar membrane (TEABM) can mimic cochlear tonotopy by triboelectrification between Kapton film and aluminum foil. The two films are stacked and clamped to form a beam structure. The TEABM tonotopy is tested using an animal model to verify the feasibility of a self-powered acoustic sensor for a prototype cochlear implant. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Carbapenem-resistant Acinetobacter baumannii carrying the NDM-1 gene, Czech Republic, 2011
Authors: A Nemec, L Krizova
Journal: Eurosurveillance (2012)

Preview this article: Carbapenem-resistant Acinetobacter baumannii carrying the NDM-1 gene, Czech Republic, 2011, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/11/art20121-en-1.gif
Local Anesthesia
Authors: Benjamin G. Covino
Journal: New England Journal of Medicine (1972)

Pharmacokinetic Considerations of Local-Anesthetic AgentsLocal-anesthetic activity and the potential toxicity of these agents are influenced by factors such as systemic absorption from site of injection, distribution, metabolism and excretion. In recent years, much information has been forthcoming concerning these various aspects, in large part owing to the development of specific and sensitive analytical methods (e.g., gas chromatography) for measuring the concentration of local-anesthetic agents in blood and tissues.AbsorptionThe various factors that influence the systemic absorption of local-anesthetic agents have been studied by several groups of investigators.67 68 69 70 In a comprehensive investigation, Braid and Scott determined the relation between . . .
Contrast medium "recalls" interleukin-2 toxicity.
Authors: R K Oldham, J Brogley, E Braud
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.5.942 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2332778 Contrast medium "recalls" interleukin-2 toxicity. R K OldhamxR K OldhamSearch for articles by this author , J BrogleyxJ BrogleySearch for articles by this author , E BraudxE BraudSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.5.942 PDF "Contrast medium "recalls" interleukin-2 toxicity.." Journal of Clinical Oncology, 8(5), pp. 942–943© 1990 by American Society of Clinical Oncology