tbuckley/cabot-search huggingface dataset:
Colorectal Cancer Screening With Colonoscopy
Authors: David Lieberman
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Liver Transplantation
Authors: Janet M. Torpy, Cassio Lynm, Robert M. Golub
Journal: JAMA (2012)

Transplant recipient Anatomy of the liver Portal veinInferior vena cava Stomach T he liver has many functions, including building proteins and other substances for the body to use, drug metabolism, and energy storage.The liver also removes waste products and toxins from the blood.Liver disease causes these crucial functions to fail.When liver failure is too severe to respond to medications, liver transplantation may be an option.Because transplantation is a major surgical procedure and there is a shortage of available donor organs, not every person with liver failure can receive a transplant.At each transplant center, a multidisciplinary team reviews and selects patients who are then placed on a waiting list for a suitable donor organ.These donor organs are allocated based on need (the most severely ill persons are considered first) and compatibility of donor and recipient.The January 18, 2012, issue of JAMA includes an article about liver transplantation in children.This Patient Page is based on one previously published in the May 10, 2006, issue of JAMA.
Chemotherapy dose escalation: case unproven.
Authors: L L Siu, I F Tannock
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.8.2765 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9256117 Chemotherapy dose escalation: case unproven. L L SiuxL L SiuSearch for articles by this author , I F TannockxI F TannockSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.8.2765 First Page PDF © 1997 by American Society of Clinical Oncology
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
Authors: Nenad Bartonicek, Jesper L. V. Maag, Marcel E. Dinger
Journal: Molecular Cancer (2016)

The previous decade has seen long non-coding RNAs (lncRNAs) rise from obscurity to being defined as a category of genetic elements, leaving its mark on the field of cancer biology. With the current number of curated lncRNAs increasing by 10,000 in the last five years, the field is moving from annotation of lncRNA expression in various tumours to understanding their importance in the key cancer signalling networks and characteristic behaviours. Here, we summarize the previously identified as well as recently discovered mechanisms of lncRNA function and their roles in the hallmarks of cancer. Furthermore, we identify novel technologies for investigation of lncRNA properties and their function in carcinogenesis, which will be important for their translation to the clinic as novel biomarkers and therapeutic targets.
Patient progress rounds on a university hospital cardiology service
Authors: C Hollingsworth, R Hoffman, C Scalzi, B Sokol
Journal: American Journal of Psychiatry (1977)

The authors describe patient progress rounds, a weekly meeting of representatives of all disciplines associated with a university hospital cardiology service. The objective is coordination of treatment for all patients in the interest of providing comprehensive care. Each patient's clinical status is reviewed, but primary attention is given to psychosocial aspects. These rounds provide a medium for identifying and dealing with patients' needs, a cooperative teaching and learning venture for staff, a multidisciplinary team approach that increases quality of care, and an opportunity for doctors to confront the reality of their patients as psychosocial beings. Case vignettes illustrate the use and effectiveness of patient progress rounds.
Hypoglycemia in Diabetes Mellitus
Authors: K Irsigler
Journal: New England Journal of Medicine (1962)

Type 1 diabetic patients experience symptomatic hypoglycemia once or twice a week. 30% of insulin-treated patients suffer from hypoglycemic coma at least once during their life, 10% at least once a year. 3% are incapacitated by frequent and severe attacks, 3 to 4% die from hypoglycemia. In contrast the incidence of symptomatic hypoglycemia in sulfonylurea-treated patients is about 0.2 per 1000 patients' years, the mortality of severe attacks being about 8%. The cause of hypoglycemia is always an excess of insulin, in absolute or relative terms. Additional precipitating factors are defective counterregulation after longer duration of diabetes, as well as a lowered threshold for counterregulation and/or for perception of warning symptoms, as seen under strict glycemic control. Considering the risks associated with hypoglycemia, preventive measures must be emphasized.
Abstract A17: A lincRNA orchestrates glioma stem cell-mediated angiogenesis in glioblastoma
Authors: Jenny J. Wang, Megan Wu, Christopher Li, Uswa Shahzad, Jason Karamchandani, Phil Marsden, Sunit Das
Journal: Cancer Research (2016)

Abstract Angiogenesis is a hallmark of glioblastoma. Recent data suggest that glioma stem cells (GSCs) contribute to pathologic angiogenesis through transdifferentiation into endothelial cells or vascular pericytes. Using an unbiased screen, we identified a lincRNA near the VEGFR1 gene, which we named LIVE (lincRNA-VEGFR1), that directs physiologic vascular network formation through global effects on gene expression. LIVE is highly expressed in glioblastoma and enriched in GSCs. Over-expression of LIVE results in specification of GSCs along a vascular lineage. LIVE associates with PARP1 in GSCs and RNA helicase A in endothelial cells to drive pericyte-specific and endothelial-associated gene expression, respectively. Depletion of LIVE in a xenograft model of glioblastoma results in decreased microvascular density, vascular perfusion and pericyte coverage, and depletion of GSCs within the vascular niche. Our findings demonstrate a novel role for lincRNAs in the orchestration of tumour angiogenesis and reveal a therapeutic potential for targeting LIVE in glioblastoma. Citation Format: Jenny J. Wang, Megan Wu, Christopher Li, Uswa Shahzad, Jason Karamchandani, Phil Marsden, Sunit Das. A lincRNA orchestrates glioma stem cell-mediated angiogenesis in glioblastoma. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr A17.
AN INDEX OF PSYCHIC DISTRESS
Authors: O E AUFRANC, W N JONES, W G STEWART
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database
Authors: Daniel P Nussbaum, Christel N Rushing, Whitney O Lane, Diana M Cardona, David G Kirsch, Bercedis L Peterson, Dan G Blazer
Journal: The Lancet Oncology (2016)
The Croonian Lectures on the Hygienic and Climatic Treatment of Chronic Pulmonary Phthisis
Authors: H. Weber
Journal: BMJ (1885)

Defective Arrangements for the Treat.ment of Phthisis in General Hospitals; Brompton and Ventnor Hos.pitals; Necessity for Nnmerous Small Hospitals for Phthiis in the Country.-ii.Bxrcisc.--iv..Manageent of Skin; Clothing
P2-140: GSTT1 polymorphism and cytogenetic changes in peripheral blood and tissues of patients suffering from lung cancer
Authors: Alena Mikhalenka, Natalia Chakava, Swetlana Palanetskaya, Natalia Chebotareva, Alexander Zilko, Yudzin Demidchik, Evelina Krupnova, Sergey Dromashko
Journal: Journal of Thoracic Oncology (2007)
Alcoholic Cardiomyopathy
Authors: DAVID H. JACKSON
Journal: Annals of Internal Medicine (1974)

Comments and Corrections1 September 1974Alcoholic CardiomyopathyDAVID H. JACKSON, M.D.DAVID H. JACKSON, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-3-415 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In the last paragraph of "The Natural Course of Alcoholic Cardiomyopathy" (Ann Intern Med80:293-297, 1974), the authors compare their data to those of McDonald, Burch, and Walsh and, it appears, incorrectly. They state that McDonald and his associates had shown a return to normal heart size in 21 of 42 patients and that that was 44%. Obviously, it is 50% of those who were followed. Furthermore, they said that in that group, the heart size of nine continued to remain normal when the patients were mobilized. But if 9 of the 21 whose heart size returned...References1. MCDONALDBURCHWALSH CGJ: Alcoholic cardiomyopathy managed with prolonged bed rest. Ann Intern Med 74: 681-691, 1971 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: The Medical Center School of Medicine University of Alabama in Birmingham Birmingham, Alabama 35233 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 September 1974Volume 81, Issue 3Page: 415-416KeywordsAlcoholicsCardiomyopathiesHeart Issue Published: 1 September 1974 PDF DownloadLoading ...
<i>Covered Wagon</i>
Authors: Jeanette M. Smith
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pretreatment Anemia Portends Poor Survival and Nonlocal Disease Progression in Patients with Stage I Non–Small Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy
Authors: Narek Shaverdian, Darlene Veruttipong, Jason Wang, Patrick Kupelian, Michael Steinberg, Percy Lee
Journal: Journal of Thoracic Oncology (2016)
Pimping as a Practice in Medical Education
Authors: Matthew Imm
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sodium lactate response and familial risk for panic disorder
Authors: A H Reschke, S Mannuzza, T F Chapman, J D Lipsitz, M R Liebowitz, J M Gorman, D F Klein, A J Fyer
Journal: American Journal of Psychiatry (1995)

The authors used the family study method to test the hypothesis that sodium lactate response defines two subtypes of panic disorder.Rates of panic disorder in 142 first-degree relatives of patients who responded to sodium lactate, 88 first-degree relatives of patients who did not respond to sodium lactate, and 231 first-degree relatives of never mentally ill subjects were compared.No difference in familial transmission of panic disorder was found between the two patient groups.The findings do not support the notion that panic disorder subtypes are associated with lactate sensitivity.
Abstract 19353: Prohibitin: A Potential Circulating Mitokine That May be Involved in Pulmonary Arterial Hypertension
Authors: Roxane PAULIN, Adam Kinnaird, Aristeidis Boukouris, Vikram Gurtu, Alois Haromy, Evangelos D Michelakis
Journal: Circulation (2015)

Introduction: In Pulmonary Arterial Hypertension (PAH), a “cancer-like” mitochondrial suppression in pulmonary vascular cells underlies in part the apoptosis resistance that characterizes the proliferative vascular remodeling. There is emerging evidence that a similar mitochondrial suppression is present in extra-pulmonary tissues like the skeletal muscle or circulating cells in PAH. We speculated that this may be due to a circulating factor. In cancer, such factors may underlie muscle wasting (cancer cachexia). In worms, there is evidence that “mitokines” secreted by one organ can “condition” other organs remotely by suppressing mitochondria. We hypothesized that Prohibitin (PHB-1; a protein increased both in the tumor and in the serum of cancer patients) maybe a candidate mitokine in PAH. Results: To determine whether the pulmonary circulation responds to endogenously produced PHB-1, we studied a rat tumor xenotransplant model with CRL-2335 breast cancer cells. Rats with tumors exhibited higher PA pressures compared to rats without tumors (mPAP=12±1mmHg vs 20±2mmHg, n=18) and this increase correlated with tumor size. Importantly, this increase in PA pressures was not due to thromboembolism and was associated with increased muscularization of resistance PAs. PHB-1 levels were increased in the PAs and serum of rats with tumors compared to controls and in the culture media of CRL2335 compared to normal cells. PASMCs exposed to Recombinant (Rec)PHB-1 displayed inhibited pyruvate dehydrogenase, increased mitochondrial membrane potential (TMRM live cell imaging 37±0.5AFU vs 53±1.2AFU), decreased mitochondrial respiration and suppressed apoptosis, mimicking the PAH phenotype. Preliminary data suggested that RecPHB-1 activates the plasma membrane receptor ErbB2, which is translocated into the mitochondria (immunoblot on isolated mitochondria and immunostaining) where it acts as a negative regulator of mitochondrial function. Conclusion: The pulmonary circulation may be responsive to endogenous circulating mitochondrial inhibitors originating from extra-pulmonary tissues. PHB-1 may be a potential mitokine in PAH.
Treatment of urinary schistosomiasis.
Authors: D M Forsyth
Journal: BMJ (1972)

Treatment of Urinary Schistosomiasis SIR,-In the leading article "Chemotherapy in Schistosomiasis" (15 January, p. 128) no reference was made to trichlorphon (metriphonate) for treating urinary schistosomiasis.This drug was used to treat hundreds of infected people in Tanzania with results which were uniformly excellent.1-3There were no toxic side-effects when 7.5 mg/kg were given by mouth at intervals of two or more weeks, there was no evidence of cumulative effects, and the capsules being tasteless were readily accepted by patients.Under favourable conditions the permanent cure rate is 100%.The drug is very cheap, much cheaper than antimony, niridazole, or hycanthone.Trichlorphon does not cure patients with intestinal schistosomiasis.'-I am, etc.,
Vascular Complications of Diabetes
Authors: Joshua A. Beckman, Mark A. Creager
Journal: Circulation Research (2016)

Over the last several decades, the global incidence and prevalence of diabetes mellitus has increased significantly. The raised incidence rate is projected to continue as greater numbers of persons adopt a Western lifestyle and diet. Patients with diabetes mellitus are at heightened risk of both adverse microvascular and cardiovascular events. Moreover, once cardiovascular disease develops, diabetes mellitus exacerbates progression and worsens outcomes. The medical management of patients with diabetes mellitus mandates comprehensive risk factor modification and antiplatelet therapy. Recent clinical trials of new medical therapies continue to inform the care of patients with diabetes mellitus to reduce both cardiovascular morbidity and mortality.
Chronic osteomyelitis: clarification of nuclear medicine findings by fusion scans.
Authors: PHILIP WIEST, MICHAEL HARTSHORNE
Journal: Clinical Nuclear Medicine (2001)

From the Imaging Service, New Mexico VA Health Care System, and the University of New Mexico Department of Radiology, Albuquerque, New Mexico Received for publication June 12, 2000. Accepted July 10, 2000. Reprint requests: Michael F. Hartshorne, Chief, Imaging Service (114), New Mexico VA Health Care System, 1501 San Pedro, SE, Albuquerque, New Mexico 87108. E-mail: [email protected]
GP is struck off for dishonesty for second time
Authors: Clare Dyer
Journal: BMJ (2015)

A GP who gave misleading evidence in a court case arising from a bitter partnership dispute between her husband and his former practice partners has been struck off the medical register for dishonesty for a second time.

Catherine Lawrance was struck off for the first time in 2014, but her case was sent back to the Medical Practitioners Tribunal Service after she successfully appealed to the High Court.

Lawrance had withdrawn part way through the first hearing, which carried …
Strengths and limitations of assessing influenza vaccine effectiveness using routinely collected, passive surveillance data in Ontario, Canada, 2007 to 2012: balancing efficiency versus quality
Authors: R D Savage, A L Winter, L C Rosella, R Olsha, J B Gubbay, D M Skowronski, N S Crowcroft
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
Predictors of outpatient mental health utilization by primary care patients in a health maintenance organization
Authors: G E Simon, M VonKorff, M L Durham
Journal: American Journal of Psychiatry (1994)

The authors examined the volume and predictors of outpatient mental health utilization among primary care patients in a large staff-model health maintenance organization (HMO).Consecutive primary care patients (N = 1,810) were screened by using the 12-item General Health Questionnaire, and a stratified random sample (N = 373) completed the 28-item General Health Questionnaire and Composite International Diagnostic Interview. Telephone interviews and computerized records were used to examine use of mental health services inside and outside the HMO over the following 3 months.Over 3 months, 6.7% of the screened patients used mental health services within the HMO. Utilization increased with higher General Health Questionnaire score (2.9% among those scoring 0, 22.3% among those scoring 8 or more) and decreased with higher out-of-pocket cost for mental health visits (7.5% for those with no change, 3.3% for those paying $30/visit). Among the interviewed subjects, 5.1% used mental health services within the HMO (mean = 2.92 visits) and 8.9% used outside mental health services (mean = 8.86 visits). Use of outside services was more strongly related to sociodemographic factors, and use of inside services was more related to severity of psychological disorder.Among these subjects, use of mental health care was high and services purchased outside the HMO exceeded those inside the HMO. Increasing copayment levels progressively reduced demand without respect to severity of illness. Attempts to control outpatient mental health costs must address equity and clinical need.
Smart hyaluronidase-actived theranostic micelles for dual-modal imaging guided photodynamic therapy
Authors: Wenjun Li, Cuifang Zheng, Zhengyin Pan, Chi Chen, Dehong Hu, Guanhui Gao, Shendong Kang, Haodong Cui, Ping Gong, Lintao Cai
Journal: Biomaterials (2016)
Human erythrocytes bearing electroinserted CD4 neutralize infection in vitro by primary isolates of human immunodeficiency virus type 1
Authors: PF Tosi, D Schwartz, U Sharma, Y Mouneimne, J Hannig, G Li, G McKinley, M Grieco, CW Flexner, J Lazarte, D Norse, C Nicolau, DJ Volsky
Journal: Blood (1996)