tbuckley/cabot-search huggingface dataset:
Abstract 2154: Paroxysmal Atrial Tachyarrhythmia (AT) as a Trigger for Heart Failure Exacerbations: Assessment by Implanted Trans-pulmonary Impedance Sensor
Authors: Rajat Jhanjee, Grant Templeton, John Nguyen, Scott Sakaguchi, Fei Lu, Keith G Lurie, Simon Milstein, Laura Van Heel, David G Benditt
Journal: Circulation (2008)

Introduction: From clinical experience, it is known that worsening of heart failure (HF) is often associated with a seemingly greater susceptibility to atrial tachyarrhythmias (AT), particularly atrial fibrillation. However, it is not clear whether it is the HF or the AT that is the sentinel event, and triggers the other. recently, certain contemporary implantable pulse generators (IPGs) are able to estimate intra-thoracic fluid status by means of detecting alterations of trans-pulmonary electrical impedance (OptiVol® [OV], Medtronic Inc). This capability permits long-term assessment of HF in pts. Employing this tool (i.e., OV) this study examined the temporal relationship between HF as assessed by OV method and AT events. Methods: Fourteen patients (pts: males, 71%, mean age 70±6.7 years) with OV-capable IPGs were enrolled. At each patient visit, OV index values since last follow-up, and AT duration (hours) were collected. OV Index &gt;60 based on Medtronic Impedance Diagnostics in Heart Failure Trial (MID-HeFT) data was used as a cutoff to signify HF. Devices were interrogated to ascertain the temporal relationship of OV Index &gt;60 and incidence of AT. Results are presented as mean ± SD. Results: Eighty-five pt visits were analyzed (mean=6.1 visits per pt, average follow-up, 21.7±5.7 months). Left-ventricular ejection fraction was 40±10%, with ischemic cardiomyopathy accounting for 57% pts. In 23 of 85 visits the OV index exceeded threshold and episodes of AT were detected by the device. Of these 23 instances in which there was AT-HF concordance, AT onset preceded the increase of OV index above threshold in 21/23 cases (91% of the time), comprising 9 of 14 pts (64%). Conclusions: In patients with both systolic HF and paroxysmal AT, our findings suggest that AT tends to precede worsening of heart failure and may act as the trigger event.
TREATMENT OF CROUPOUS PNEUMONIA.
Authors: M BURGER
Journal: JAMA (1891)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life according to Wilde
Authors: F. Charatan
Journal: BMJ (2004)

vided doctors with guidelines for levels of blood pressure that should be considered out of control, we asked them to use their own judgment. Satisfaction with medical careAll of the factors measured for patient satisfaction were equivalent in the two groups, as was patients' satisfaction with the care of their blood pressure by their doctor (see bmj.com).More patients in the six month group thought that the doctor did not take their blood pressure problem seriously enough towards the end of the study. Adherence to treatmentAdherence to treatment was equivalent between groups.However, we found that pill counts in this pragmatic trial were unreliable.
A survey of Canadian psychiatric residents regarding resident-educator sexual contact
Authors: M L Carr, G E Robinson, D E Stewart, D Kussin
Journal: American Journal of Psychiatry (1991)

A survey of all Canadian psychiatric residents was undertaken to ascertain the prevalence of resident-educator sexual contact in training programs, the residents' feelings about this contact, their knowledge of the ethical standards of the profession, and the extent of the information they had been given about this subject. An investigator-designed questionnaire was circulated to all psychiatric residents in Canada through the directors of postgraduate training programs. To ensure confidentiality, the residents returned their questionnaires directly to the investigators.Of the 314 respondents, 4.1% (N = 6) of the female residents and 1.2% (N = 2) of the male residents reported sexual involvements with their educators. Although the majority of these eight residents had positive or neutral feelings about the contact, 37.5% (N = 3) of the involved residents had mixed feelings. The residents' education concerning resident-educator sexual contact was strikingly sparse.This study highlights the need for inclusion of this tissue in residency programs.
LMI-14PRACTICAL IMPLEMENTATION OF 3-D RADIOTHERAPY TRAINING IN AFRICA WITH A FOCUS ON PAEDIATRIC NEURO-ONCOLOGY
Authors: Jeannette Parkes, Hester Burger, Nanette Bruwer, Bridget Wyrley-Burch, Jose-Manuel Valentim, Jens Groll
Journal: Neuro-Oncology (2016)
AT-22ALISERTIB MONOTHERAPY IN THE TREATMENT OF RELAPSED ATYPICAL TERATOID RHABDOID TUMOR (ATRT)
Authors: Magimairajan Issai Vanan, Patrick McDonald, Colin Kazina, Junliang Liu, Sherry Krawitz, Martin Bunge, Annie Ong, Brent Orr
Journal: Neuro-Oncology (2016)

AT-22. ALISERTIB MONOTHERAPY IN THE TREATMENT OF RELAPSED ATYPICAL TERATOID RHABDOID TUMOR (ATRT) Magimairajan Issai Vanan1, Patrick McDonald2, Colin Kazina3, Junliang Liu1, Sherry Krawitz4, Martin Bunge5, Annie Ong1, and Brent Orr6; CancerCare Manitoba/Winnipeg Children’s Hospital, Winnipeg, MB, Canada; Pediatric Neuro-surgery/BC Children’s Hospital, Vancouver, BC, Canada; Pediatric Neuro-Surgery/University of Manitoba, Winnipeg, MB, Canada; Neuropathology/University of Manitoba, Winnipeg, MB, Canada; Radiology/University of Manitoba, Winnipeg, MB, Canada; Pathology/ St Jude Children’s Research Hospital, Memphis, TN, USA Atypical teratoid rhabdoid tumors (ATRTs) account for up to 20% of brain tumors in children less than 3yrs of age. The overall prognosis of ATRTs is extremely poor with median survival in the range of 10-18mths from the time of diagnosis. Aurora A Kinase (AURKA) encodes a protein that regulates the formationandstabilityof themitotic spindleand ishighlyactive inATRTthrough loss of the INI1 tumor suppressor gene. Alisertib (MLN8237) is a selective small molecule inhibitor of AURKA. We report a case of recurrent ATRT treated with alisertib monotherapy producing sustained and durable disease remission. Our patient underwent gross total resection (GTR) of the Posterior fossa tumor at diagnosis and was initially treated as per ACNS0333 protocol. She remained in remission for 15 months after completion of chemotherapy when she relapsed in the right frontal lobe. She underwent sub-total resection (STR) followed by focal IMRT (54Gy/30 fractions) followed by chemotherapy (DFCI-IRS-III, modified protocol) with Doxorubicin / Etoposide alternating with Actinomycin-D and triple intrathecal chemotherapy. After 7 months of treatment, she relapsed again in the right frontal region, presenting with focal seizures. She received 10 cycles of alisertib (60mg/m2 by mouth once daily for 7 days of a 21 day treatment cycle) monotherapyand is clinically stablewith her imaging showingsustained regression of disease. Somnolescence and neutropenia were the most common side effects seen in our patient. Neuro-Oncology 18:iii1–iii6, 2016. doi:10.1093/neuonc/now065.21 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
AT-19SYSTEMATIC RADIOLOGICAL PHENOTYPING OF ATYPICAL TERATOID RHABDOID TUMOURS USING LANGUAGE MODELLED MACHINE LEARNING APPROACHES
Authors: John-Paul Kilday, Michal Zapotocky, John Keane, Dimitrios Karanopoulos, Suzanne Laughlin, Annie Huang, Stavros Stivaros
Journal: Neuro-Oncology (2016)
Uterine Sensitivity to Progesterone (Deciduoma Reaction) in Mice of High and Low Mammary Tumor Incidence
Authors: Alexander Symeonidis, Prosper Loustalot
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Uterine Sensitivity to Progesterone (Deciduoma Reaction) in Mice of High and Low Mammary Tumor Incidence Get access Alexander Symeonidis, Alexander Symeonidis Search for other works by this author on: Oxford Academic PubMed Google Scholar Prosper Loustalot Prosper Loustalot National Cancer Institute4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 4, February 1953, Pages 851–857, https://doi.org/10.1093/jnci/13.4.851 Published: 01 February 1953 Article history Received: 17 September 1952 Published: 01 February 1953
Action of BAL on the Tumor-Damaging Potency of Certain Trivalent Arsenic Compounds
Authors: L V BECK
Journal: JNCI Journal of the National Cancer Institute (1952)

Action of BAL on the Tumor-Damaging Potency of Certain Trivalent Arsenic Compounds Lyle V. Beck Lyle V. Beck Department of Physiology and Pharmacology, University of Pittsburgh School of Medicine, and Laboratory of Chemical Pharmacology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 3, December 1952, Pages 619–625, https://doi.org/10.1093/jnci/13.3.619 Published: 01 December 1952 Article history Received: 12 May 1952 Published: 01 December 1952
Resection of Colon or Rectum for Malignant Neoplasm in Patients 80 Years of Age and Older
Authors: C W MAYO, R A JOHNSON
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transthoracic 3D Echocardiographic Left Heart Chamber Quantification Using an Automated Adaptive Analytics Algorithm
Authors: Wendy Tsang, Ivan S Salgo, Diego Medvedofsky, Masaaki Takeuchi, David Prater, Lynn Weinert, Megan Yamat, Victor Mor-Avi, Amit R Patel, Roberto M Lang
Journal: JACC. Cardiovascular imaging (2016)
Elimination of Latently HIV-infected Cells from Antiretroviral Therapy-suppressed Subjects by Engineered Immune-mobilizing T-cell Receptors
Authors: Hongbing Yang, Sandrine Buisson, Giovanna Bossi, Zoë Wallace, Gemma Hancock, Chun So, Rebecca Ashfield, Annelise Vuidepot, Tara Mahon, Peter Molloy, Joanne Oates, Samantha J Paston, Milos Aleksic, Namir J Hassan, Bent K Jakobsen, Lucy Dorrell
Journal: Molecular Therapy (2016)

Persistence of human immunodeficiency virus (HIV) in a latent state in long-lived CD4+ T-cells is a major barrier to eradication. Latency-reversing agents that induce direct or immune-mediated cell death upon reactivation of HIV are a possible solution. However, clearance of reactivated cells may require immunotherapeutic agents that are fine-tuned to detect viral antigens when expressed at low levels. We tested the antiviral efficacy of immune-mobilizing monoclonal T-cell receptors against viruses (ImmTAVs), bispecific molecules that redirect CD8+ T-cells to kill HIV-infected CD4+ T-cells. T-cell receptors specific for an immunodominant Gag epitope, SL9, and its escape variants were engineered to achieve supraphysiological affinity and fused to a humanised CD3-specific single chain antibody fragment. Ex vivo polyclonal CD8+ T-cells were efficiently redirected by immune-mobilising monoclonal T-cell receptors against viruses to eliminate CD4+ T-cells from human histocompatibility leukocyte antigen (HLA)-A*0201-positive antiretroviral therapy-treated patients after reactivation of inducible HIV in vitro. The efficiency of infected cell elimination correlated with HIV Gag expression. Immune-mobilising monoclonal T-cell receptors against viruses have potential as a therapy to facilitate clearance of reactivated HIV reservoir cells.
Psychiatric peer review: the Washington, D.C., experience, 1972-1975
Authors: P Chodoff, P Santora
Journal: American Journal of Psychiatry (1977)

The authors describe the method by which claims review for psychiatric practice is carried out by an APA district branch peer review committee in the Washington, D.C., metropolitan area and analyze the claims reviews handled by the committee from 1972 through 1975. On the basis of their findings they conclude that peer review of psychiatric treatment can be carried out in a medical framework, that it can have some effect in diminishing costs incurred by improper utilization or by abuses, and that it can improve the quality of psychiatric practice.
Abstract 2314: Altered Metabolism of Asymetric Dimethylarginine (ADMA) is Associated with Endothelial Dysfunction and Negative Arterial Remodelling After Heart Transplantation
Authors: Andrew Wilson, Sean Virani, Cecile Holweg, Jan Kielstein, Stefanie Bode-Boger, Hannah Valantine, John P Cooke, William F Fearon
Journal: Circulation (2007)

Cardiac allograft vasculopathy (TAV) is a diffuse and progressive form of coronary artery disease occurring after heart transplantation (HT) characterized by endothelial dysfunction (ED) and negative arterial remodeling. However, TAV risk factors are not well understood. We hypothesized that asymmetric dimethylarginine (ADMA), a circulating inhibitor of nitric oxide synthase, mediates HT related ED and remodeling. Methods and Results Forty eight consecutive cardiac transplant recipients underwent baseline angiography within 8 weeks of cardiac transplantation and at 1 year after transplantation. Intravascular ultrasound indices were measured at baseline and 1 year in all and coronary response to infused acetylcholine and glyceryl trinitrate at 1 year as a measure of ED in 31 subjects. ADMA and its circulating metabolite symmetric DMA (SDMA) were measured at 8 weeks and 1 year by LC-mass spectroscopy. Rejection was diagnosed histologically in endomyocardial biopsies and subjects were subdivided into those with without treated rejection in the first year after HT. Responses to Ach were significantly impaired in patients with a history of treated rejection in the first year after transplant versus those without rejection (mean % change vessel diameter ± SD; −19.4 ± 12.7 versus −8.4 ± 10.2, p = 0.026). There was no difference in response to glyceryl trinitrate in those with and without rejection. Plasma ADMA levels decreased significantly after HT (0.55 ±0.12 versus 0.48 ± 0.09 micromol/l, p &lt;0.001). Using stepwise multivariate regression in a model including age, gender, lipid levels, glucose and blood pressure, plasma ADMA was an independent correlate of Ach coronary artery response 1 year after transplant (p = 0.004, R2 = 46%). Other predictors were female gender and rejection. The ADMA/SDMA ratio (a marker of ADMA breakdown) was correlated inversely with change in vessel volume and change in lumen volume as measured by IVUS between baseline and 1 year (r = −0.036, p = 0.04). Conclusion Levels of ADMA correlated with impaired endothelial function as did episodes of treated rejection. The ADMA/SDMA ratio, a marker of ADMA breakdown, correlated with negative arterial remodeling. Abnormalities in ADMA metabolism may contribute to the pathogenesis of CAV.
LG-58THERAPEUTIC IMPLICATIONS OF MOLECULAR BIOMARKERS IN INFANTS WITH PEDIATRIC LOW-GRADE GLIOMA
Authors: Ana Guerreiro Stucklin, Alvaro Lassaletta, Matthew Mistry, Anthony Arnoldo, Scott Ryall, Cino Ling, Rahul Krishnatry, Nataliya Zhukova, Michal Zapotocky, Vijay Ramaswamy, Ute Bartels, Annie Huang, Eric Bouffet, Cynthia Hawkins, Uri Tabori
Journal: Neuro-Oncology (2016)
Three vs. 1 year of adjuvant imatinib (IM) for operable high-risk GIST: The second planned analysis of the randomized SSGXVIII/AIO trial.
Authors: Heikki Joensuu, Mikael Eriksson, Kirsten Sundby Hall, Annette Reichardt, Giuliano Ramadori, Peter Hohenberger, Salah-Eddin Al-Batran, Marcus Schlemmer, Sebastian Bauer, Daniel Pink, Justus Duyster, Bengt E. Nilsson, Odd R Monge, Raija Kallio, Petri Bono, Jouni Junnila, Eva Wardelmann, Thor Alvegard, Peter Reichardt
Journal: Journal of Clinical Oncology (2015)

10505 Background: Three years of adjuvant IM is recommended after surgery for patients (pts) with high-risk GIST with an IM-sensitive mutation. This recommendation is based on the findings from the SSGXVIII/AIO trial that compared 1 year (Arm A) to 3 years (Arm B) duration of administration of adjuvant IM. After a median follow-up of 4.5 yrs, 3 yrs of IM resulted in superior recurrence-free survival (RFS) and overall survival (OS), but the OS benefit was based only on 37 events. Methods: Pts with high-risk GIST according to the modified NIH risk stratification who had GIST resected macroscopically completely were eligible. The pts were randomly assigned 1:1 to Arm A or B, and were scheduled to receive IM 400 mg/day either for 12 or 36 months after surgery. Tumor histology was reviewed centrally after randomization. The study protocol was amended in October 2006 to exclude pts who had completely resected metastatic disease from the study. We now present the second planned analysis of the trial based on a median follow-up time of 7.5 years. Results: 400 patients were entered to this multicenter, open study between February 4, 2004, and September 29, 2008. The 397 pts who provided informed consent formed the Intention-To-Treat (ITT) population (A, 199; B, 198 pts). Pts who did not have GIST at central pathology review (n = 15) and those with metastatic GIST at study entry (n = 24) were excluded to form the Efficacy Population (i.e. “the true adjuvant GIST population”; A, 181; B, 177). In this second analysis, 171 recurrences and 68 deaths were detected (ITT). Pts assigned to 3 yrs of IM had longer RFS (HR 0.60, 95% CI 0.44 - 0.81; P < 0.001) and longer OS (HR 0.61, 95% CI 0.38 - 1.00; P = 0.046) than those assigned to 1 yr of IM in the ITT population, and also in the Efficacy Population (HR 0.62; 95% CI 0.45-0.85; P=0.003; and HR 0.54, 95% CI 0.31-0.96; P = 0.032, respectively). 5-year OS was 86.8% and 93.4% in the 1-year and 3-year groups, respectively, despite the high-risk features of GISTs (Efficacy Population). The frequency of cardiac events (A, 10; B, 6) and the numbers of second cancers (A, 18; B, 23) were similar in the groups. Conclusions: Three years of adjuvant IM resulted in superior RFS and OS as compared to 1 year of IM. Clinical trial information: NCT00116935.
Partial hospitalization (day treatment) for psychiatrically ill elderly patients
Authors: D A Plotkin, K B Wells
Journal: American Journal of Psychiatry (1993)

The purpose of this paper is to present initial findings from a retrospective chart review of geriatric day treatment patients in order to focus attention on this potentially important area, add to the limited database in this area, and generate hypotheses for future investigations.Data were abstracted from the charts of 100 geriatric day treatment patients over a period of approximately 5 years (1985-1989). Descriptive, univariate, and multiple regression techniques were used to describe the patients and identify variables associated with their outcomes.The typical patient in this program was a widowed white woman in her 70s who suffered from a depressive disorder. During the initial treatment period (usually approximately 3 months), 57% of the patients experienced some clinical improvement. Variables associated with a favorable outcome included diagnosis of a mood disorder rather than a psychotic disorder, better initial functional status, greater initial social support, fewer stressful events during treatment, and longer duration of treatment.Geriatric day treatment can be effective and merits further study as a mode of treatment for psychiatrically ill elderly patients.
The Proceedings of the Fourth Annual Meeting of the Association of Military Surgeons of the United States.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Publicly Funded HIV Counseling and Testing—United States, 1990
Authors: J T Weber, R L Frey, R Horsley, M L Gwinn
Journal: JAMA (1991)

Data are collected and reported through the Centers for Disease Control and Prevention (CDC) Counseling and Testing System (CTS) on episodes of publicly funded counseling and HIV testing in the Unites States. The objective of this analysis is to describe testing data reported from 1992 through 1995. In 1992, 2,689,056 tests were performed, and 55,024 (2.0%) were positive; in 1995, 2,491,434 tests were performed, of which 40,605 (1.6%) were positive. Among tests reported with client-level data, the proportion of tests of men and women at higher risk for HIV infection remained stable or declined; the proportion of tests of persons who had been previously tested increased each year; and in 1995, the proportion of tests that included posttest counseling was 86% for anonymous and 70% for confidential tests. Although information collected through CTS could be improved by changing the system so that individuals could be distinguished from testing episodes, the CTS does provide important monitoring information to local and state health departments.