tbuckley/cabot-search huggingface dataset:
Imported extensively drug-resistant Mycobacterium tuberculosis Beijing genotype, Marseilles, France, 2011
Authors: S Cohen-Bacrie, I Ben Kahla, E Botelho-Nevers, M Million, P Parola, P Brouqui, M Drancourt
Journal: Eurosurveillance (2011)

Multidrug- (MDR) and extensively drug-resistant (XDR) tuberculosis (TB) are reported to gradually spread across European countries with low TB prevalence including France. Some isolates may even accumulate traits of resistance in addition to the XDR profile, as a result of therapeutic mismanagement. We report here the first case of XDR TB in Marseilles and discuss the potential effectiveness of sulfamide treatment in such cases.
Lineage Instructive Function of C/EBPα in Multipotent Hematopoietic Progenitor Cells Revealed in a Novel Cebpa-Cre Knock-in Model
Authors: Albert Wolfler, Astrid A Danen-van Oorschot, Jurgen Haanstra, Marijke Valkhof, Paulette van Strien, Elwin Rombouts, Ivo P Touw
Journal: Blood (2008)
Use Of Rearranged Immune Receptor Sequencing To Measure Minimal Residual Disease (MRD) In Bone Marrow, Cerebrospinal Fluid and Testes In Relapsed Childhood Acute Lymphoblastic Leukemia
Authors: Norman J. Lacayo, Li Weng, Charles Gawad, Malek Faham, Gary V Dahl
Journal: Blood (2013)
Updated Outcomes and Impact of Age With Lenalidomide and Low-Dose Dexamethasone or Melphalan, Prednisone, and Thalidomide in the Randomized, Phase III FIRST Trial
Authors: Cyrille Hulin, Andrew Belch, Chaim Shustik, Maria Teresa Petrucci, Ulrich Dührsen, Jin Lu, Kevin Song, Philippe Rodon, Brigitte Pégourié, Laurent Garderet, Hannah Hunter, Isabelle Azais, Richard Eek, Heinz Gisslinger, Margaret Macro, Shaker Dakhil, Cristina Goncalves, Richard LeBlanc, Ken Romeril, Bruno Royer, Chantal Doyen, Xavier Leleu, Fritz Offner, Nicolas Leupin, Vanessa Houck, Guang Chen, Annette Ervin-Haynes, Meletios A. Dimopoulos, Thierry Facon
Journal: Journal of Clinical Oncology (2016)

Purpose This analysis of the FIRST trial in patients with newly diagnosed multiple myeloma (MM) ineligible for stem-cell transplantation examined updated outcomes and impact of patient age. Patients and Methods Patients with untreated symptomatic MM were randomly assigned at a one-to-one-to-one ratio to lenalidomide plus low-dose dexamethasone until disease progression (Rd continuous), Rd for 72 weeks (18 cycles; Rd18), or melphalan, prednisone, and thalidomide (MPT; 72 weeks), stratified by age (≤ 75 v > 75 years), disease stage (International Staging System stage I/II v III), and country. The primary end point was progression-free survival. Rd continuous and MPT were primary comparators. Results Between August 21, 2008, and March 7, 2011, 1,623 patients were enrolled (Rd continuous, n = 535; Rd18, n = 541; MPT, n = 547), including 567 (35%) age older than 75 years. Higher rates of advanced-stage disease and renal impairment were observed in patients older than 75 versus 75 years of age or younger. Rd continuous reduced the risk of progression or death compared with MPT by 31% (hazard ratio [HR], 0.69; 95% CI, 0.59 to 0.80; P < .001) overall, 36% (HR, 0.64; 95% CI, 0.53 to 0.77; P < .001) in patients age 75 years or younger, and 20% (HR, 0.80; 95% CI, 0.62 to 1.03; P = .084) in those age older than 75 years. Median overall survival was longer with Rd continuous than with MPT, including a 14-month difference in patients age older than 75 years. Progression-free survival with Rd18 was similar to that with MPT, and overall survival with Rd18 was marginally inferior to that with Rd continuous. Rates of grade 3 to 4 treatment-emergent adverse events were similar for Rd continuous-treated patients age 75 years or older and those age older than 75 years; however, older patients had more frequent lenalidomide dose reductions. Conclusion Results support Rd continuous treatment as a new standard of care for stem-cell transplantation-ineligible patients with newly diagnosed MM of all ages.
Tobacco giant loses legal action over Uruguay’s tobacco packaging rules
Authors: Ingrid Torjesen
Journal: BMJ (2016)

International tobacco company Philip Morris has lost its legal challenge against Uruguay’s tobacco packaging rules, which it argued violated its trade rights under investment agreements between Uruguay and Switzerland.

Philip Morris, which has its headquarters in Switzerland, first brought its case in 2010, claiming $25m (£19.3m; €22.6m) in damages over laws enacted in Uruguay in 2006 that banned tobacco advertising and smoking in public. Under Uruguay’s …
Obstructive Sleep Apnea: Update and Future
Authors: Diane C. Lim, Allan I. Pack
Journal: Annual Review of Medicine (2016)

Obstructive sleep apnea (OSA) is a worldwide disease whose prevalence is increasing as obesity rates increase. The link between obesity and OSA is likely to be the deposition of fat in the tongue, compromising upper airway size. The role of obesity varies in different ethnic groups, with Chinese being particularly sensitive to increases in weight. OSA lends itself to a personalized approach to diagnosis and therapy. For example, different clinical OSA subtypes likely benefit from therapy in different ways. Hypoglossal nerve stimulation is a useful second-line therapy in patients who cannot tolerate continous positive airway pressure (CPAP) machines or intraoral devices. Technological advances allow patients to participate in their own care, and doing so improves CPAP compliance. We are entering a future where we can focus efforts to predict and prevent OSA on an individual level.
Preclinical evaluation of anti-MET antibodies for immunohistochemical staining.
Authors: Hartmut Koeppen, Chenery Lowe, Sandra Rost
Journal: Journal of Clinical Oncology (2014)

11103 Background: The monovalent anti-MET antibody onartuzumab in combination with erlotinib showed clinical benefit in a phase II trial in advanced non-small cell lung cancer (NSCLC); this benefit was limited to MET-positive tumors as determined by immunohistochemistry (IHC) using the CONFIRM anti-total MET rabbit monoclonal antibody (Ventana). The trial results demonstrate the importance of a reliable IHC assay to distinguish MET-positive from MET-negative cancers. Therefore, it is important to gain a pre-clinical understanding of available antibodies that may warrant further investigation. The aim of this study was to evaluate nine anti-MET antibodies for sensitivity and specificity using various standard staining conditions. Methods: All antibodies were evaluated on eight formalin-fixed paraffin-embedded (FFPE) cell lines with known RNA and protein (ELISA) MET expression levels. Antibodies with adequate sensitivity and specificity were then analyzed on a NSCLC tissue microarray (TMA) and on whole sections of NSCLC and gastric adenocarcinoma (GAC) of known MET status. The antibody evaluation included four autostainers (Ventana Benchmark XT, Leica BOND-III, Dako Autostainer Plus and Dako Omnis), 14 antigen retrieval (AR) methods and 7 detection methods. Results: The SP44 and D1C2 antibodies showed staining on cell lines, NSCLC TMA, and large sections of NSCLC and GAC of adequate sensitivity and specificity when used under the following conditions: (1) Ventana Benchmark XT with CC1 standard and CC1 extended AR, (2) Leica BOND-III with ER2 AR, (3)DAKO Autostainer with EnVision FLEX Target High pH AR. All other antibodies and AR/detection methodologies showed inferior staining characteristics due to insufficient sensitivity and/or specificity. Conclusions: SP44 and D1C2 showed staining performance similar in sensitivity and specificity to the CONFIRM anti-Total MET antibody. Additional validation on larger cohorts of clinically annotated tissues is required prior to any clinical application. MET antibodies. Vendor Clone or product # Spring Bioscience SP44 Cell Signaling D1C2 My Biosource 3D4 IBL polyclonal #18321 Santa Cruz N-17; C-12; C-28 Abcam 8F11 R&D Systems polyclonal #AF276
Case 14-1964
Authors: Charles S. Davidson, Benjamin Castleman
Journal: New England Journal of Medicine (1964)

Presentation of Case*A seventy-two-year-old automobile mechanic entered the hospital because of abdominal swelling.Fourteen years previously he had pneumonia and thereafter had a chronic cough that was productive of small amounts of clear sputum. Five years before admission exertional dyspnea appeared, and he was told that he was hypertensive. During the year before entry he lost 35 pounds in weight and was intermittently constipated. Three months before admission he experienced steady, aching pain in the anterior portion of the chest for a week; an electrocardiogram was interpreted as normal. During the two months before entry he became increasingly fatigued, . . .
Historique des épidémies de trichinellose liées à la consommation de viande chevaline, 1975-1998
Authors: T Ancelle
Journal: Eurosurveillance (1998)

La trichinellose se transmet a l'homme par la consommation de viande, crue ou peu cuite, d'animaux eux-memes contamines par le parasite du genre Trichinella. Dans la nature, le cycle implique la plupart des animaux carnivores, omnivores et de nombreux rongeurs. Les animaux domestiques peuvent etre infectes, notamment le porc (1).
Virus Replication and Cell Modifications in Organ Cultures of Tumor Tissue From Chickens With Marek's Disease
Authors: Françoise Coudert, L. Cauchy
Journal: JNCI Journal of the National Cancer Institute (1975)

Organ cultures of lymphomas from chickens infected with Marek's disease (MD) virus were examined by electron microscopy at various periods after explantation. Nonenveloped herpes-type virions were observed in explants 18 days after the culture was initiated. Cytolytic virus was replicated often in lymphoblastoid cells and occasionally in other cell types (permissive and nonpermissive transformed). The permissive cells were numerous, but non permissive transformed cells were also present as indicated by the longevity of some cultures. The presence of both permissive and transformed cell types in the organ cultures and reasons for their sequential appearance were discussed. The results unequivocally demonstrated that lymphoid cells of tumors induced by MD virus were sites of virus replication under proper culture conditions.
Persistent Structural Plasticity Optimizes Sensory Information Processing in the Olfactory Bulb
Authors: Kurt A. Sailor, Matthew T. Valley, Martin T. Wiechert, Hermann Riecke, Gerald J. Sun, Wayne Adams, James C. Dennis, Shirin Sharafi, Guo-li Ming, Hongjun Song, Pierre-Marie Lledo
Journal: Neuron (2016)
P-121 Phase Ib trial of oxaliplatin, UGT1A1 genotype-directed dosing of irinotecan and chronomodulated capecitabine (OXIRI) chemotherapy in patients with advanced pancreatic cancer
Authors: C. Ng, B. Chowbay, S.P. Choo, D. Tai, N. Somasundaram, Y. Yu, S. Lam, Y. Chang
Journal: Annals of Oncology (2016)
Prognostic factors for actual 5-year survivors after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal cancer with peritoneal surface disease.
Authors: P. Shen, G. Watson, J. H. Stewart, T. P. McCoy, E. A. Levine
Journal: Journal of Clinical Oncology (2010)

3601 Background: Cytoreductive surgery (CS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for metastatic colorectal cancer has been reported to produce long-term survivors in selected patients. This survival benefit has been mostly derived from actuarial data. In this study actual 5-year survivors are examined to determine outcomes and prognostic factors. Methods: Retrospective review of a prospectively maintained database was performed on patients who underwent CS and HIPEC for colorectal peritoneal surface disease from 1991-2004. Overall survival (OS) was calculated from the time of surgery using the Kaplan-Meier method. Results: There were 119 consecutive patients identified. Resection status was R0/R1 and R2 in 55 (46.2%) and 64 (53.8%) patients, respectively. Median OS was 17.4 months (95% CI = [14.7, 22.7]).There were 16 actual 5- year survivors with a median f/u of 101.1 months (range = 64.5-164.5). In this group there were 14 R1/R0 and 2 R2 resections. Thirty-one percent of these patients died after their 5-year follow-up. On univariate analysis of the entire cohort, prognostic factors for OS were ECOG performance status (p = 0.010), ascites (p < 0.001), bowel obstruction (p < 0.001), pre-op CEA levels (p = 0.006), and resection status (p < 0.001). The 5-year OS for all patients undergoing R0/R1 and R2 resections was 28.6% (95% CI = [17.3, 40.9]) and 4.7% (95% CI = [1.2%, 11.8%]), respectively. Patients undergoing R1/R0 resections (25.5%) were more likely to survive longer than five years compared to those undergoing R2 resections (3.1%) (p = 0.003). Conclusions: More than a quarter of patients were actual long-term survivors after complete cytoreduction of peritoneal surface disease and HIPEC for metastatic colorectal cancer. However among 5-year survivors, one third will still die from recurrent cancer. Patients with incomplete resection of all gross disease have poor long-term clinical outcomes. No significant financial relationships to disclose.
In vivo imaging and quantification of oxygen tension within solid tumor.
Authors: Wen Jiang, Yuanxin Chen, Steven H. Lin, Betty Y.S. Kim
Journal: Journal of Clinical Oncology (2016)

e23154 Background: The tumor microenvironment plays a critical role in regulating cancer cell survival, proliferation, and invasiveness. It also acts as key driver in promoting tumor-mediated evasion of host immune surveillance. Low oxygen tension or hypoxic conditions are well known to be associated with immune suppressive properties. Despite its importance, characterizations of intratumoral hypoxia have been limited by indirect studies of hypoxia related gene and proteins expressions as well as ex-vivo staining of surrogate markers. In vivo, real-time, direct measurements of oxygenation status can provide important insights into pathophysiology and immunological characteristics of solid tumors. Methods: Utilizing two-photon phosphorescence lifetime microscopy, our study aims to quantify local oxygen tension within solid tumors in vivo. Using murine glioma as a model system, we performed non-invasive measurements of oxygen partial pressures (pO2 ) within different regions of a single tumor. High-resolution intravital microscopy simultaneously correlated pO2 quantifications with structural characterizations to demonstrate functional oxygen mapping within the tumor. Results: We demonstrated that a significant degree of local pO2 heterogeneity exists within the tumor. We also observed a positive correlation of intratumoral blood vessel perfusion capacity with pO2 . Treatments with anti-VEGFr antibody and conventional chemotherapy significantly altered the local oxygen tension profile, potentially due to modification of tumor vascular supply and oxygen consumption, respectively. Interestingly, while the change in pO2 after anti-VEGFr treatment is predominantly located within the peripheral regions of the tumor, administration of chemotherapy resulted in the alteration of pO2 throughout the tumor interstitium. Conclusions: Our study provided a new platform to study the endogenous tumor microenvironment and generated direct evidence of its spatiotemporally heterogeneity. Importantly, our data also demonstrated a dynamic response of the metabolic tumor microenvironment towards stress-inducing stimuli, and how this may have contributed to tumor therapeutic response and the development of drug resistance.
Assessment of the Ki67 labeling index: A Japanese validation ring study.
Authors: Naoki Niikura, Takashi Sakatani, Nobuyuki Arima, Yasuyo Ohi, Naoko Honma, Naoki Kanomata, Kazuya Yoshida, Takayuki Kadoya, Kentaro Tamaki, Nobue Kumaki, Takayuki Iwamoto, Tomoharu Sugie, Takuya Moriya
Journal: Journal of Clinical Oncology (2014)

e11538 Background: A lack of consistent methods to evaluate Ki67 expression is problematic in terms of accurately predicting prognosis in breast cancer. Accordingly, this study aimed to identify the causes of discrepancies in Ki67 labeling index measurements by different observers under different conditions using breast cancer samples. Methods: This Japanese study group compared and assessed immunohistochemical (IHC) analysis of the Ki67 labeling index when measured by different pathologists. Six pathologists (pathologists A–F) in Japan participated in this ring study. One hundred and ten surgical cases of estrogen receptor-positive and human epidermal growth factor receptor 2-negative invasive breast cancer treated in 2007 were identified from the breast cancer database of Tokai University Hospital and were included in this study. Results: For all 6 pathologists, the Ki67 labeling index were significantly different between grade 3 and grade 1 cases and between grade 3 and grade 2 cases, whereas the index tended to be different between grade 1 and grade 2 cases. Further, the Ki67 labeling index measured by the 6 pathologists were strongly correlated (Rho: 0.73–0.88). The IHC scores recorded by pathologist A were in fair to good agreement with those recorded by the others in patients with a Ki67 labeling index of <13.25% and in those with a Ki67 labeling index of >13.25% (κ = 0.429–0.660). The Ki67 low and high concordance rates between pathologist A and the others were 0.452–0.778 and 0.862–0.979, respectively. The most pertinent reason for discrepancy in scores seemed to be the selection of the area for counting and the quality of nuclear staining. Conclusions: The Ki67 labeling index measured by 6 pathologists without method standardization were in fair to good agreement. We plan to undertake a second ring study, pending recommendations by the international Ki67 panel.
A Young Woman With Recurrent Atrial Fibrillation
Authors: Ashish H. Shah, Diego Delgado, S. Lucy Roche
Journal: JAMA Cardiology (2016)

An 18-year-old woman was referred to our adult congenital heart disease center for investigation of chest pain and atrial fibrillation (AF).She had reported intermittent chest pain without precipitating factors since the age of 8 years.This had been evaluated by a pediatric cardiologist and was felt to be noncardiac in nature.Persistence of pain and associated distress eventually prompted referral to adolescent psychiatry.At age 17 years she experienced 3 episodes of AF, each treated with direct-current cardioversion.An electrophysiologist commenced treatment with flecainide and warfarin.Warfarin was stopped after 6 months arrhythmia-free.At our clinic, she reported intermittent, nonexertional, atypical chest pain and exertional dyspnea with a gradual decline in exercise capacity, confirmed by cardiopulmonary exercise test (oxygen consumption peak 65% predicted).Electrocardiogram demonstrated sinus rhythm, a prominent biphasic p-wave, and occasionally prolonged interval between the beginning of the electrocardiographic wave representing ventricular depolarization and the end of the T-wave (QT, QTc up to 594 milliseconds) (Figure 1A).Transthoracic echocardiogram revealed normal ventricular dimensions and systolic function with biatrial dilatation (left > right) (Figure 1B), dilated pulmonary veins, and abnormal diastolic filling.Cardiac magnetic resonance imaging with gadolinium confirmed dilatation of the atria, pulmonary veins, and inferior vena cava with normal ventricular size, mass, and ejection fraction without enhancement suggestive of infarction, inflammation, or fibrosis.Pericardium was of normal thickness.Electrocardiogram A Transthoracic echocardiogram B Figure 1.A, Electrocardiogram demonstrating prominent and biphasic P-wave and ST-T segment abnormalities.B, Four-chamber view of transthoracic echocardiogram.aVF indicates augmented vector foot; aVL indicates augmented vector left arm; and aVR indicates augmented vector right arm.WHAT WOULD YOU DO NEXT? A. Start diuretic, β-blocker, and angiotensin-converting enzyme inhibitor B. Start diuretic, implant cardioverter defibrillator, and evaluate for cardiac transplantation C. Discontinue flecainide, start amiodarone and warfarin
Symptom Burden and Health-Related Quality Of Life (HRQoL) In Patients With Myelofibrosis (MF) Treated With Fedratinib (SAR302503) In a Phase III Study (JAKARTA)
Authors: Ruben A. Mesa, Jorge E. Cortes, Francisco Cervantes, Donald Milligan, Tamás Masszi, Elena Mishchenko, Eric Jourdan, Alessandro M. Vannucchi, Mark Drummond, Mindaugas Jurgutis, Kazimierz Kuliczkowski, Emanuil Gheorghita, Francesco Passamonti, Frank Neumann, Florence Joulain, Sheikh Usman Iqbal, Claire N Harrison
Journal: Blood (2013)
DSM-III subclassification of dissociative disorders applied to psychiatric outpatients in India
Authors: S Saxena, K V Prasad
Journal: American Journal of Psychiatry (1989)

In subclassifying 62 cases of DSM-III dissociative disorders in India, the authors found that 56 (90.3%) fell into the atypical subcategory. These cases could be easily separated into two additional subcategories, simple dissociative disorder and possession disorder, by using specified diagnostic criteria.
Expression of Vascular Endothelial Growth Factor in Ovarian Cancer Inhibits Tumor Immunity through the Accumulation of Myeloid-Derived Suppressor Cells
Authors: Naoki Horikawa, Kaoru Abiko, Noriomi Matsumura, Junzo Hamanishi, Tsukasa Baba, Ken Yamaguchi, Yumiko Yoshioka, Masafumi Koshiyama, Ikuo Konishi
Journal: Clinical Cancer Research (2016)

Abstract Purpose: High VEGF expression in ovarian cancer is an unfavorable prognostic factor. However, the role of VEGF in tumor immunity remains unclear. Here, we examined the impact of VEGF on local immunity, including induction of myeloid-derived suppressor cells (MDSC), in ovarian cancer. Experimental Design: High-grade serous ovarian cancer (HGSOC) cases were analyzed by gene expression microarray and IHC for VEGF, CD8, and CD33. VEGF receptor (VEGFR) 1 and VEGFR2 expression levels on MDSCs were analyzed in a mouse model, and the direct effects of VEGF-A on MDSC expansion were investigated. Gr1+ MDSCs and lymphocyte frequencies were analyzed in control tumors and tumors derived from cells harboring short hairpin RNA targeting Vegf-a. In addition, the therapeutic effects of anti-Gr-1 antibodies were examined. Results: Microarray analysis revealed the upregulation of several myeloid cell chemoattractants and the downregulation of lymphocyte-related pathways in cases with high VEGF expression. In immunohistochemical analysis, VEGF expression in peritoneal dissemination correlated with MDSC infiltration. Cases with high MDSC infiltration, which was inversely correlated with intratumoral CD8+ T-cell infiltration, exhibited shorter overall survival. In a mouse model, intratumoral MDSCs expressed both VEGFR1 and VEGFR2. MDSC migration and differentiation were augmented by VEGF signaling. Vegf-a knockdown in tumor cells resulted in decreased MDSC infiltration and increased CD8+ T-cell infiltration. Moreover, treatment with anti-Gr-1 antibodies delayed the growth of control tumors, whereas Vegf-a-knockdown tumors were unaffected by anti-Gr-1 antibody treatment. Conclusions: VEGF expression in ovarian cancer induced MDSCs, inhibited local immunity, and contributed to poor prognosis. Clin Cancer Res; 23(2); 587–99. ©2016 AACR.
Late News: International Workshop Assesses Evidence for Breast Screening
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Late News : International Workshop Assesses Evidence for Breast Screening Get access Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 6, 17 March 1993, Pages 436–438, https://doi.org/10.1093/jnci/85.6.436 Published: 17 March 1993