tbuckley/cabot-search huggingface dataset:
Focal neurologic symptoms in panic attacks
Authors: P K Coyle, A B Sterman
Journal: American Journal of Psychiatry (1986)

Among 350 referrals to a neurology service, 19 (5%) had panic attacks manifesting as focal neurologic symptoms. Diagnostic clues included multiple symptoms, normal results on neurologic examination, personal stress, dietary extremes, age 20-50 years, and symptom reproduction by hyperventilation. Focal neurologic symptoms should not exclude a diagnosis of panic attack.
Limbus Vertebra on Bone Scintigraphy in a Pediatric Patient
Authors: Wei Zhang, Summer L. Kaplan, Sabah Servaes, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2015)

Limbus vertebra involving the anterosuperior corner of a vertebral body is usually seen in adult patients, and it generally does not cause symptoms. An 8-year-old girl experienced lower back pain. Bone SPECT images revealed significantly increased tracer activity in the region of the anterior L4 vertebral body, which was shown on MRI to be a limbus vertebra.
Case 6-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Arthur T. Skarin, John C. Long
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 56-year-old woman was admitted to the hospital because of the nephrotic syndrome.She was well until 10 years earlier, when a respiratory-tract infection developed. The cold agglutinins were positive in a titer of 1:16. One year later she began to have joint pains, with stiffness of the shoulders, hips and back. Six years before admission the erythrocyte sedimentation rate was 43 mm per hour. Three years before entry a psoriasiform rash developed. One year later a violaceous rash was observed over the anterior aspects of the shins. The joint pains improved but recurred during the next . . .
SAT0465 Construct Validity of the Promis-29 in Systemic Sclerosis: Preliminary Results from the Scleroderma Patient-Centered Intervention Network (Spin) Cohort
Authors: L. Kwakkenbos, B.D. Thombs, S. Bartlett, M. Hudson, L. Mouthon, V. Malcarne, M. Sauvé, D. Khanna
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Patient-Reported Outcomes Measurement Information System (PROMIS®) initiative is a cooperative research program designed to develop, evaluate, and standardize item banks to measure patient-reported outcomes across medical conditions. The PROMIS-29 measure contains 29 items, which include four items each for domains reflecting physical function, anxiety, depression, fatigue, sleep disturbance, pain interference, and ability to perform social roles, plus a single item on pain intensity. Scores are standardized with a mean of 50 and standard deviation (SD) of 10. Higher scores represent more of the domain being measured (e.g., greater sleep disturbance, greater ability to perform social roles). <h3>Objectives</h3> To examine feasibility and construct validity of the PROMIS29 in patients with systemic sclerosis (SSc) enrolled in a large multinational study. <h3>Methods</h3> English-speaking patients with SSc and ≥18 years of age were enrolled in the Scleroderma Patient-centered Intervention Network (SPIN) Cohort between April 2014 and January 2015 from 17 centers across Canada, the USA and the UK. Baseline medical data are provided by the enrolling physician, and SPIN Cohort patients complete outcome measures online every 3 months. Patients were included in the analyses if they completed at least one PROMIS-29 domain at baseline. Floor and ceiling effects were defined as &gt;15% of patients having the lowest or highest possible domain score, respectively. To examine convergent validity of domains, hypotheses were formulated a-priori about the associations of domains and legacy measures. The magnitude of the correlations was interpreted as small (|r| ≤0.3), moderate (0.3 &lt; |r| &lt;0.5), or large (|r| ≥0.5). <h3>Results</h3> In total, 376 patients were included in analyses. Mean age was 55.1 years (SD=11.9) and mean time since onset of the first non-Raynaud symptom was 14.4 years (SD=11.8). Most patients were female (n=329, 87.5%) and diagnosed with limited SSc (n=207, 55.1%). Means for the PROMIS-29 domains were: function 42.4 (SD=8.7), anxiety 51.8 (SD=10.1), depression 50.9 (SD=9.3), fatigue 56.2 (SD=11.4), sleep 52.0 (SD=5.2), roles 47.4 (SD=9.5), pain interference 55.9 (SD=9.8), and pain intensity 3.8 (SD=2.7). There was a floor effect for anxiety (33.8%) and depression (37.7%), and ceiling effects for function (19.1%), roles (15.1%) and pain interference (24%). Most hypotheses were confirmed (7 of 9) and all were in the hypothesized direction (Table 1). <h3>Conclusions</h3> Results of our study support the construct validity of the PROMIS-29 in patients with SSc. Future studies should examine the influence of floor- and ceiling effects for some domains, as well as other psychometric properties of the measure. <h3>Disclosure of Interest</h3> None declared
Pericardial Effusion
Authors: John L. Zeller, Cassio Lynm, Richard M. Glass
Journal: JAMA (2007)

Pericardial EffusionT he pericardium is a thin sac that surrounds the heart and the large blood vessels closely associated with the heart.The pericardium has an inner and an outer layer with a small amount of lubricating fluid between them.Pericarditis is a condition in which the pericardium becomes inflamed (increased blood flow and a protective cell response due to injury).With pericarditis, the amount of fluid increases within the pericardial layers, squeezes the heart, and can restrict the motion of the heart.This is called a pericardial effusion.If the onset is rapid or if the volume of the pericardial effusion is large, cardiac tamponade can occur.Cardiac tamponade diminishes the force of heart contractions because of compression by the fluid trapped within the pericardial space.Among individuals with a pericardial effusion, 7% to 10% are at risk of developing a cardiac tamponade.The April 25, 2007, issue of JAMA includes an article that discusses the accuracy of the medical history, physical examination, and basic diagnostic tests for the diagnosis of cardiac tamponade.
More on Chewing Gum
Authors: D A Florman
Journal: New England Journal of Medicine (2000)

Hepatic Arterial Infusion of Chemotherapy for Metastatic Colorectal CancerTo the Editor: The study of hepatic arterial infusion of chemotherapy after resection of hepatic metastases in patients with colorectal cancer, reported by Kemeny et al. (Dec.30 issue), 1 represents a positive development in the management of colorectal cancer.However, clinicians planning to use this therapy may be confused by the dosages reported in the article.By convention, the dosage for hepatic intraarterial chemotherapy is based on the amount of drug delivered to the patient.Since infusion devices have variable flow rates and deliver only part of their contents in 14 days, the total dose of floxuridine placed in the device is much more than the dose the patient receives.Kemeny et al. state that the infusion pump was filled with "0.25 mg of floxuridine per kilogram of body weight per day for 14 days in combination with 20 mg of dexamethasone; 50,000 U of heparin, and enough normal saline to result in a volume of 50 ml."This does not mean that the dose delivered to patients was 0.25 mg per kilogram per day for 14 days.Because the average flow rate for these devices is approximately 2.0 ml per day, the dose of floxuridine that each patient received was about 0.14 mg per kilogram per day.Given the risk of hepatobiliary toxicity and the narrow therapeutic index for this treatment, 2 the dose of hepatic intraarterial floxuridine is a critical factor in the safe administration of regional chemotherapy.The dose of floxuridine should be based on the flow rate of the pump used to deliver the drug.
Review of behavioral psychotherapy, II: sexual disorders
Authors: I M Marks
Journal: American Journal of Psychiatry (1981)

Sexual dysfunction has been shown to respond to a "behavioral Masters and Johnson" approach. Several controlled studies have found this approach to be superior to other methods, with one follow-up showing improvement up to 18 months later. Good results have usually been obtained using one rather than two therapists per couple. This brings into question whether the doubling of expense by use of two therapists is justified by the marginal gains in outcome. Results of early group treatment experiments with couples with sexual dysfunction have been encouraging. Behavioral methods are also useful in reducing a variety of sexual deviations (paraphilias); recent emphasis has moved away from the patient being passively averted by the therapist toward devising his own self-management program, including self-administered aversion when necessary.
Season of birth in schizophrenia and neurosis
Authors: E H Hare
Journal: American Journal of Psychiatry (1975)

National studies in Scandinavia and in England and Wales have shown that schizophrenic patients are born significantly more often in the early months of the year than would be expected from comparison with the general population. The author examines additional evidence from England and Wales and discusses possible sources of technical error. Although there is currently no evidence of a causal association between season of birth and schizophrenia, he suggests that this possibility should be given consideration.
Epidemiologic surveillance system implemented in the Hautes-Alpes District, France, during the Winter Olympic Games, Torino 2006
Authors: F Franke, L Coulon, C Renaudat, B Euillot, N Kessalis, P Malfait
Journal: Eurosurveillance (2006)

Some of the competitions of the Olympic Winter Games in Torino, 10 to 26 February 2006, were organised in France near the city of Briançon, in the department of Hautes-Alpes. An epidemiologic surveillance system was set up by the local health authorities. The goals were to detect in a timely fashion any phenomenon which could justify prevention or sanitary control action, and to guide interventions in the case of outbreak or environmental pollution. Surveillance was implemented from 30 January to15 March 2006 in the Briançon area. Mortality was tracked using by analysing the number and cause of deaths. A sentinel network of general practitioners was set up and reported the frequency of acute gastroenteritis, influenza-like illness and measles. Medical laboratories provided data about the analyses they undertook. Hospital emergency department and emergency ambulance service activities were followed up. Statutory notification diseases and toxic effects of carbon monoxide surveillances were reinforced. Analysed data were transmitted daily to the health authorities. A French/English report was sent weekly to all participants. The participation rate was close to 100%, and data transmission deadlines were respected. No adverse health event was identified. The strong acceptability of this surveillance system comes from its good understanding by the participants. This surveillance, structured around routine and ad-hoc systems, allowed the establishment of the foundations of a network to be used in case of outbreak or environmental pollution.
Government Moves To Increase Taxol Supply
Authors: E. Blurne
Journal: JNCI Journal of the National Cancer Institute (1991)

Government Moves To Increase Taxol Supply Get access Elaine Blurne Elaine Blurne Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Pages 1054–1056, https://doi.org/10.1093/jnci/83.15.1054 Published: 07 August 1991
Clinical staging in rhabdomyosarcoma: current limitations and future prospects.
Authors: P A Pizzo, T J Triche
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.1.8 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3806163 Clinical staging in rhabdomyosarcoma: current limitations and future prospects. P A PizzoxP A PizzoSearch for articles by this author , T J TrichexT J TricheSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.1.8 PDF "Clinical staging in rhabdomyosarcoma: current limitations and future prospects.." Journal of Clinical Oncology, 5(1), pp. 8–9© 1987 by American Society of Clinical Oncology
Hypnotically induced auditory hallucinations and the mouth-opening maneuver: a failure to duplicate findings
Authors: E E Levitt, T G Waldo
Journal: American Journal of Psychiatry (1991)

The authors sought to replicate the part of a study by Bick and Kinsbourne in which hypnotically induced auditory hallucinations in normal volunteer subjects were abolished by requiring the subjects to open their mouths.Sixty-four normal volunteer subjects were hypnotized, and an attempt was made to induce auditory hallucinations. The subjects in whom hallucinations were successfully induced were then asked to perform the mouth-opening maneuver and the control maneuvers of putting their fingers in their ears or squeezing their eyes shut in an effort to end the hallucinations.Sixteen subjects reported having hallucinations. None of them reported that a hallucination was abolished by opening the mouth or closing the eye; four reported ending hallucinations by putting their fingers in their ears.Opening the mouth does not affect auditory hallucinations induced by hypnosis in normal persons. The most likely reason for the discrepancy between the results of this experiment and those of the Bick and Kinsbourne study is that the design of the latter study was faulty because it permitted demand characteristics to influence the results.
The &lt;italic&gt;In Vivo&lt;/italic&gt; Effect on Liver Catalase by a Tumor&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;
Authors: J P GREENSTEIN
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article The In Vivo Effect on Liver Catalase by a Tumor Get access Jesse P. Greenstein Jesse P. Greenstein Laboratory of Biochemistry, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue Supplement_5, April 1955, Pages 1603–1605, https://doi.org/10.1093/jnci/15.Supplement_5.1603 Published: 01 April 1955
PTH-002 The yield of pathology from diagnostic flexible sigmoidoscopy in patients under 40yrs
Authors: P Orchard, M Rashid, C Thorn, R Alexander
Journal: Gut (2015)

<h3>Introduction</h3> Flexible sigmoidoscopy (FS) allows both macroscopic and histological assessment of the left colon and rectum. Current guidelines define the need for FS in patients over 40 yrs, but is lacking in those under 40 yrs. <h3>Method</h3> Data was analysed from our prospectively collected database over a 1 year period (April 2013–14). Patients undergoing diagnostic FS under 40ys were included (n = 136). Fisher’s exact and Chi squared were used for analysis. <h3>Results</h3> 38 patients (28%) yielded pathology; 29 (21%) had a colitis, 5 (4%) had polyps, and 4 patients had other benign pathology. No patients had a cancer. Analysis of indication for FS, indicated a non-significant (p = 0.09) propensity of finding pathology in patients with rectal bleeding and abdo pain or change of bowel habit (46%). Our data supports a smaller published series (Mittapalli <i>et al</i>2008) for pathology yield (p = 0.33). <h3>Conclusion</h3> This study provides evidence that FS in the under 40’s identifies pathology in approximately 1 in 4 patients. Presenting with a PR bleed in addition to other symptoms is, perhaps more likely to yield pathology. <h3>Disclosure of interest</h3> None Declared.
Plastic surgeons support centralisation of services
Authors: P J Sykes
Journal: BMJ (1995)

objective of a reduction in weight.This is the only measure of dietary compliance presented, except that 74% and 69% of non-obese and obese subjects respectively remained on the diet alone (but with no weight loss; in fact they gained weight).I appreciate the difficulties of doing such a large study over so many years with so many centres participating, but this does not excuse the authors from drawing conclusions that may be misleading.A more prudent conclusion might have been that dietary advice given as part of normal care did not work but that there is no evidence to say whether a predetermined diet, given under controlled conditions with compliance properly monitored, is not effective.At a pragmatic level "usual care" is what people get, and this study is therefore helpful in that sense, but if readers draw the conclusion that diet does not work under any circumstances then this paper will have been unhelpful.
Visualization of an Incidental Ectopic Gallbladder Location on 99mTc-MIBI Myocardial Perfusion Imaging With SPECT/CT
Authors: Po-Nien Hou, Cheng-Kai Huang, Jay Wu
Journal: Clinical Nuclear Medicine (2015)

An ectopically located gallbladder is rare and unusual. In this study, we described a case of a 52-year-old woman who underwent SPECT–myocardial perfusion imaging because of exertional dyspnea and chest tightness. The rest sinograms reveal 2 substantially increased tracer uptakes in the right chest. Subsequently, a SPECT/CT scan was performed to clarify the indeterminate findings on the SPECT–myocardial perfusion imaging. The coregistered SPECT/CT images depict intense focal activity in the right chest, which corresponds to the gallbladder on the CT scan, thus explaining the peculiar ectopic gallbladder finding.
AB0967 Auto-Inflammatory Diseases Are a Main Cause of Early-Onset Panniculitis
Authors: B. Bader-Meunier, I. Melki, F. Touzot, J.-L. Casanova, B. Neven, P. Quartier, C. Wouters, S. Fraitag, C. Bodemer
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Childhood-onset panniculitides are rare and classically include infectious, connective tissue, malignant, metabolic, and drugs, cold or trauma-induced panniculitis. Some specific types of panniculitis are only seen in neonates and very young infants, and include subcutaneous fat of the newborn, poststeroid panniculitis, sclerema neonatorum, and cold panniculitis. However, no specific discoverable etiology can be identified in many patients. <h3>Objectives</h3> To describe the spectrum of clinical and pathological manifestations of childhood-onset panniculitis of unknown cause <h3>Methods</h3> A retrospective single-center study of children presenting with panniculitis diagnosed by skin biopsy <h3>Results</h3> Eighteen patients were identified. The onset of symptoms occurred within the first two years of life in 15/18 patients (83%). Panniculitis was the revealing manifestation in 15/18 (83%) patients, and relapsed in 13/18 (72%) patients. Associated-non-cutaneous features occurred in 16/18 (89%) patients, especially autoinflammatory manifestations in 13/18 patients (72%), associated with immunodeficiency in 5 patients (low T or B cells count with hypogammaglobulinemia in 4 and 1 patients respectively). Autoinflammatory manifestations consisted in attacks of fever with an elevation of acute phase reactants associated with polyarthritis or polyarthralgia (2 patients), rash (2 patients) or aseptic adenitis (2 patients). Panniculitis was mostly lobular in 10 (55%) patients, septal in 3 (17%) patients or both in 5 patients (28%). Predominant infiltrate consisted of neutrophils, cytophagic histiocytes, lymphocytes, eosinophils in 8 (44%), 5 (28%), 3 (17%), and 1 (5.5%) patients respectively, and included granuloma in 1 patient. No relationship was found between clinical and pathological features. Genomic mutations were identified in 3 of the 4 patients who underwent genetic analysis: mutations in <i>TRNT1</i>, <i>MVK</i> (mevalonate kinase) and <i>LCK</i> genes. <h3>Conclusions</h3> This series underlines that auto-inflammatory diseases, possibly associated with inherited immunodeficiency, are a main cause of early-onset panniculitis. The identification of a monogenic cause in 3 patients and the early-onset presentation of the disease suggest that a subset of patients has a genetic predisposition to develop panniculitis, especially early-onset panniculitis. <h3>Disclosure of Interest</h3> None declared
PTH-082 Factors associated with rating of care and the family and friends test: secondary analysis of the uk ibd audit inpatient experience survey
Authors: T Gledhill, K Bodger
Journal: Gut (2015)

<h3>Introduction</h3> There is growing emphasis on subjective care ratings as a tool to drive standards. The simple ‘Friends and Family Test’ is offered to all NHS inpatients after discharge. We included a selection of ‘rating’ style questions in the UK IBD audit inpatient experience survey.<sup>1</sup>This secondary analysis further evaluated patient factors associated with variation in ratings and explored their correlation with survey items asking about hospital experiences relevant to UK IBD Standards. <h3>Method</h3> Responses to inpatient questionnaire (3<sup>rd</sup>round UK IBD audit) were analysed. Factors associated with overall rating (‘Rating’: ‘How would you rate the care you received?’) and the Friends and Family Test (‘FFT’: ‘Would you recommend this hospital to your friends and family?’) were explored: age, gender, disease type, admission type (emergency medical; emergency surgery; elective surgery) and health state at the time of questionnaire completion (EQ5D). 15 items were mapped onto specific IBD standards. <h3>Results</h3> 2,067 respondents (UC 1,078, CD 989; 42.6% male; mean age 46.2 yrs; Elective surgery 20.7%, Emergency surgery 12.3%; 67.0% Medical therapy). Patients with CD had a lower QoL (EQ5D: UC 0.75 vs. CD 0.69, p &lt; 0.001). Most patients (90.3%) reported good, v. good or excellent care; 90.4% of patients would probably or definitely recommend the hospital to friends and family. Increasing age correlated with better score (Rating: r = 0.136; FFT: r = 0.153). Mean scores of males higher than females (Rating: 4.17 vs. 3.92; FFT 2.58 vs. 2.43; p &lt; 0.001), and UC patients answered more favourably (Rating: UC 4.09 vs. CD 3.96; FFT UC 2.52 vs. CD 2.47; p &lt; 0.05). Emergency medical patients had least favourable responses. Better QoL correlated with Rating (r = 0.207) and FFT (r = 0.173). In multiple regression, independent variables predictive of Rating were EQ5D, age and gender, whereas for FFT the predictors were EQ5D, age, gender and type of admission. Correlation with 15 items linked to IBD standards varied from weak (Dietician Visit, r = 0.07) to moderately strong (‘Enough information to manage condition after discharge’, r = 0.50). In regression models adjusting for patient factors, only 5 of 15 questions were retained for ‘rating’ (r-sq: 0.47) and 4 for FFT (r-sq: 0.31). <h3>Conclusion</h3> In IBD patients, ‘rating’ style questions are influenced by independent patient variables and current state of health and require careful interpretation. Correlation with questions relevant to IBD standards is variable, confirming that patient experience surveys should include items that map onto specific events and experiences rather than subjective ratings alone. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> UK IBD Audit. National report of the results of the UK IBD audit 3rd round inpatient experience questionnaire responses. https://www.rcplondon.ac.uk/projects/ibdauditround3