tbuckley/cabot-search huggingface dataset:
Association of Acetaminophen Use During Pregnancy With Behavioral Problems in Childhood
Authors: Evie Stergiakouli, Anita Thapar, George Davey Smith
Journal: JAMA Pediatrics (2016)

<h3>Importance</h3> Acetaminophen (paracetamol) is used by a large proportion of pregnant women. Research suggests that acetaminophen use in pregnancy is associated with abnormal fetal neurodevelopment. However, it is possible that this association might be confounded by unmeasured behavioral factors linked to acetaminophen use. <h3>Objective</h3> To examine associations between offspring behavioral problems and (1) maternal prenatal acetaminophen use, (2) maternal postnatal acetaminophen use, and (3) partner’s acetaminophen use. <h3>Design, Setting, and Participants</h3> From February 2015 to March 2016, we collected and analyzed data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a prospective birth cohort. We studied 7796 mothers enrolled in ALSPAC between 1991 and 1992 along with their children and partners. <h3>Exposures</h3> Acetaminophen use was assessed by questionnaire completion at 18 and 32 weeks of pregnancy and when the child was 61 months old. <h3>Main Outcomes and Measures</h3> Maternal reports of behavioral problems using the Strengths and Difficulties Questionnaire (SDQ) when the children were 7 years old. We estimated risk ratios for behavioral problems in children after prenatal, postnatal, and partner’s exposure to acetaminophen and mutually adjusted each association. <h3>Results</h3> Maternal prenatal acetaminophen use at 18 (n = 4415; 53%) and 32 weeks of pregnancy (n = 3381; 42%) was associated with higher odds of having conduct problems (risk ratio [RR], 1.42; 95% CI, 1.25-1.62) and hyperactivity symptoms (RR, 1.31; 95% CI, 1.16-1.49), while maternal acetaminophen use at 32 weeks was also associated with higher odds of having emotional symptoms (RR, 1.29; 95% CI, 1.09-1.53) and total difficulties (RR, 1.46; 95% CI, 1.21-1.77). This was not the case for maternal postnatal (n = 6916; 89%) or partner’s (n = 3454; 84%) acetaminophen use. We found the associations between maternal prenatal acetaminophen use and all the SDQ domains unchanged even after adjusting for maternal postnatal or partner’s acetaminophen use. <h3>Conclusions and Relevance</h3> Children exposed to acetaminophen prenatally are at increased risk of multiple behavioral difficulties, and the associations do not appear to be explained by unmeasured behavioral or social factors linked to acetaminophen use insofar as they are not observed for postnatal or partner’s acetaminophen use. Although these results could have implications for public health advice, further studies are required to replicate the findings and to understand mechanisms.
Phase 1b/2a Open-Label, Multiple-Dose, Dose-Escalation Study To Evaluate The Safety and Tolerability Of Intravenous Infusion Of SNS01-T In Patients With Relapsed Or Refractory Multiple Myeloma, Mantle Cell Lymphoma, Or Diffuse Large B Cell Lymphoma
Authors: John A Lust, Charles Barranco, Saad Z Usmani, Frits van Rhee, Mehdi Hamadani, John Thompson, Catherine A Taylor, Richard Dondero, Leslie J. Browne, David Siegel, William I. Bensinger
Journal: Blood (2013)
Social and economic factors in patients with coronary disease
Authors: P. L. Morris
Journal: JAMA (1992)

To the Editor.  —The JOURNALrecently published two articles and an Editorial on the influence of social and economic factors on mortality following coronary artery disease. 1-3 Psychosocial effects on mortality following vascular disease affecting another end organ, the brain, have been studied by our group in recent years. Our findings are of relevance to the observations published inTHE JOURNAL.  In an initial study of 88 Australian stroke patients followed up for 15 months, we found that depressed patients had a sevenfold higher risk of death than nondepressed patients (odds ratio, 7.9; 95% confidence interval, 1.2 to 53.2). 4 In a second series of 91 patients in Baltimore, Md, followed up for 10 years, we found that initially depressed patients had nearly three-and-a-half times the risk of death than nondepressed patients (odds ratio, 3.4; 95% confidence interval, 1.4 to 8.2). This finding held true even when other risk
Use of Epinephrine for Cardiac Arrest Prior to Hospital Arrival—Reply
Authors: Akihito Hagihara, Takeru Abe, Takashi Nagata
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Internet-Based Cognitive Behavioral Therapy for Social Anxiety with and without Guidance Compared to a Wait List in China: A Propensity Score Study
Authors: Tomoko Kishimoto, Tobias Krieger, Thomas Berger, Mingyi Qian, Huijing Chen, Yin Yang
Journal: Psychotherapy and Psychosomatics (2016)

Letter to the Editor (approx.200 million adult people) in combination with a huge unmet need for treatment of mental disorders [1] .Internet interventions might be an easily accessible and cost-effective way to deliver evidence-based treatment for mental disorders to people who otherwise never would have the opportunity to receive effective treatment.Although there is a wealth of studies that show the efficacy and effectiveness of Internet-based cognitive behavioral therapy (ICBT) in Western countries, there is a considerable lack of studies that investigate the efficacy of such treatments in non-Western countries [2] .So far, several studies have evaluated the efficacy of ICBT for SAD in controlled trials in Western countries with promising results [3] .An important discussion in the field is about the degree of support and guidance needed during Internet-based selfhelp treatments [4] .The aim of the present study was to investigate the effectiveness of an established self-help program for increased social anxiety in a Chinese population.Additionally, we investigated whether minimal guidance by trained therapists had an incremental value regarding symptom improvement and adherence.The present study was approved by the local ethics committee.Participants were recruited by announcements on websites and sev-Social anxiety disorder (SAD) is one of the most common mental disorders in Western countries.The 12-month prevalence of SAD in China is much lower (0.2%) than in Western countries.However, it translates into an enormous number of people in China
Is It Time to Redefine Response in Elderly Patients with WHO-Acute Myeloid Leukemia (AML) Unfit for Intensive Chemotherapy?
Authors: Lisa Pleyer, Sonja Burgstaller, Reinhard Stauder, Michael Girschikofsky, Heinz Sill, Konstantin Schlick, Josef Thaler, Britta Halter, Sigrid Machherndl-Spandl, Armin Zebisch, Angelika Pichler, Michael Pfeilstöcker, Eva-Maria Autzinger, Alois Lang, Klaus Geissler, Daniela Voskova, Dietmar Geissler, Wolfgang R Sperr, Sabine Hojas, Inga Mandac Rogulj, Johannes Andel, Richard Greil
Journal: Blood (2015)
HIF expression and Max-SUV-18F-FDG-PET in non-small cell lung cancer (NSCLC) patients
Authors: R. Lopez, E. Gallardo, A. Ruibal, L. Leon, A. Sanchez-Salmon, I. Abdulkader, F. Gude, T. Curiel, J. Barandela, L. Gayoso
Journal: Journal of Clinical Oncology (2009)

e22010 Background: Tumor hipoxia induces the up-regulation of several genes via the hipoxia-inducible transcription factors (HIF) 1 and 2. HIF-2 alpha (HIF-2 α) and HIF-1 alpha (HIF-1α) are associated with the prognosis of operable NSCLC patients. We studied the immunohistochemical expression of HIF-1α and HIF-2 α in patients with NSCLC and the possible correlation with the maximum standardised uptake value (max SUV) of 18F-FDG as well as other biological parameters. Methods: We used a Tissue Arrayer device (Beecher Instruments. WI) to construct a TMA block, according to conventional protocols for the study of immunohistochemical expression of HIF-1α, HIF-2 α, EGFR, bcl-2, MIB1, p16, p63 and cyclins A, B1, D1 and D3. Sections were scored as positive if &gt;10% of cells stained positively. Staining patterns were correlated to clinical variables. Results: HIF- 1α expression was observed in 84/96 patients (34/39 adenocarcinomas and 50/57 squamous cell carcinomas), however it did not correlate with clinical stage (I-II: 41/45 vs III-IV: 44/51). HIF-1α correlated positively with HIF-2 α (p:0,001) and EGFR (p:&lt;0,001) expressions. The maxSUV values of 18F-FDG-PET were higher (p:0,039) in HIF-1α -positive (17,1±8,6) than in negative tumors (11,8±4,4). HIF-2 α expression was observed in 60/103 cases (27/42 adenocarcinomas and 33/61 squamous cell carcinomas) and it did not correlate with clinical stage ((I-II: 28/45 vs III-IV: 32/57). HIF-2 α correlated positively with HIF-1α (p:0,001), MIB1 (p:0,045) and EGFR (p:0,091) expressions. After multivariate analysis, only the clinical stage (RR: 2,2) was a prognostic factor. Conclusions: 1) HIF-1α and HIF-2 α expressions are frequent in patients with NSCLCs and it did not correlate with clinical stage; 2) maxSUVs FDG-PET values were higher in HIF1alpha positive than in HIF-1α negative patients; 3) HIF-1α was correlated with EGFR expression, while HIF-2 α was correlated with MIB1 expression. No significant financial relationships to disclose.
Correction: Guidelines for Accurate and Transparent Health Estimates Reporting: the GATHER statement
Authors: Gretchen A. Stevens, Leontine Alkema, Robert E. Black, J. Ties Boerma, Gary S. Collins, Majid Ezzati, John T. Grove, Daniel R. Hogan, Margaret C. Hogan, Richard Horton, Joy E. Lawn, Ana Marušić, Colin D. Mathers, Christopher J. L. Murray, Igor Rudan, Joshua A. Salomon, Paul J. Simpson, Theo Vos, Vivian Welch
Journal: PLoS Medicine (2016)

[This corrects the article DOI: 10.1371/journal.pmed.1002056.].
Cytomegalovirus Reactivation After Allogeneic Stem Cell Transplantation Is Associated With a Reduced Risk Of Relapse In Patients With Acute Myeloid Leukemia: The Japan Society For Hematopoietic Cell Transplantation (JSHCT) Transplantation-Related Complication Working Group
Authors: Katsuto Takenaka, Tetsuya Nishida, Yuki Asano-Mori, Kumi Oshima, Gaku Oshikawa, Koichi Miyamura, Tetsuya Eto, Hirohisa Nakamae, Hisashi Sakamaki, Yasuo Morishima, Ritsuro Suzuki, Takuhiro Yamaguchi, Takahiro Fukuda
Journal: Blood (2013)
Abstract P3-14-05: Recurrence in Patients Diagnosed with Ductal Carcinoma in Situ: Predictors and Prognostic Significance
Authors: GR Sue, B Killelea, NR Horowitz, DR Lannin, AB Chagpar
Journal: Cancer Research (2012)

Abstract Background: While patients diagnosed with ductal carcinoma in situ (DCIS) enjoy a favorable prognosis, recurrence after definitive management does occur in a subset of these patients. Factors influencing the development of recurrence, and the ultimate impact of this event on overall survival, remain poorly understood. We sought to determine clinicopathologic factors affecting recurrence and the prognostic role this plays in patients with DCIS. Methods: A retrospective chart review of 205 consecutive patients who presented to an academic breast center with DCIS from 2000 to 2003 was conducted under an IRB-approved protocol. Non-parametric statistical analyses comparing patients who recurred to those who did not were then performed using SPSS Statistical Software. Results: With a median follow-up of 8.5 years, 14 (6.8%) of the 205 patients who presented with DCIS between 2000–2003 had an invasive or in situ recurrence. The median age of all patients at the time of diagnosis of their initial DCIS was 55.5 years (range; 35.8–88.9). 51 (24.9%) had possible (albeit not definitive) microinvasion on their initial specimen. The majority were grade 2 (91; 44.4%), and 99 (48.3%) had comedo histology. The median size of DCIS on the initial excision was 10 mm (range; 0.1–80). All patients underwent definitive surgery to negative margins. The mean time to recurrence was 4.7 years (range; 1.1–10.6). On bivariate analysis, histologic grade of DCIS was the only factor that was significantly correlated with the risk of recurrence. Patients with grade 3 DCIS were more likely to develop a recurrence compared to those with grade 2 or grade 1 DCIS (12.3% vs. 3.3% vs. 0%, respectively, p = 0.032). Patient age, race, extent of DCIS, and histologic subtype were not associated with recurrence (see table below). 5-year actuarial overall survival was no different between those who developed a recurrence and those who did not (92.9 vs. 95.7%, p = 0.171). Conclusions: Approximately 7% of patients diagnosed with DCIS will recur within 10 years. Patients with high grade DCIS are more likely to recur, and this seems to be more predictive of recurrence than other clinicopathologic markers. Irrespective of whether or not patients with DCIS recur, overall survival is not significantly different between these two groups, and patients with DCIS enjoy an outstanding prognosis regardless. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-14-05.
Retrospective assessment of adherence to ASCO Surveillance Guidelines following treatment for stage II and III colorectal cancer (CRC)
Authors: J. M. Davies, S. Lupichuk, E. Batuyong, R. J. Hilsden, J. Easaw
Journal: Journal of Clinical Oncology (2009)

e17517 Background: The 2005 ASCO guidelines for surveillance following adjuvant therapy for CRC outlined recommended surveillance tests and their frequencies including history and physical examination, CEA testing, CT scan and colonoscopy. The purpose of this study was to assess the impact of these guidelines post treatment of stage II and III CRC in the Calgary Health Region (CHR) before and after implementation of a computer generated, personalized discharge letter (DL). Methods: Cohort 1 patients completed adjuvant chemotherapy or radiotherapy for stage II and III CRC between September 1, 2006, and November 30, 2007, prior to implementation of the DL. Cohort 1 was retrospectively identified from the Alberta Cancer Registry. Registry data was collated with laboratory data and diagnostic imaging data is forthcoming. Adherence to the guidelines at 1-year follow-up in cohort 1 was measured. Prospective data collection on patients who completed adjuvant treatment after implementation of the DL (cohort 2) is ongoing. Comparison of adherence rates to surveillance testing between the two cohorts will be reported upon study completion. Results: For cohort 1, 209 of 238 patients referred to the cancer centre were from the CHR and hence included in the analysis. The average age was 65 and 53% were male. Most patients (136/209) had stage III CRC. 1/209 had a local recurrence only. 27/209 progressed to metastatic disease during the 1-year follow-up period, of which 23 of these patients were initially diagnosed with stage III CRC. CEA adherence (≥4 tests taken within 1-year follow-up period) was 38.3% (95% CI 31.7–44.9). CT scan adherence and use of “inappropriate” surveillance testing for cohort 1 will be available at the meeting. Conclusions: This study assesses compliance with the 2005 ASCO CRC surveillance guidelines at 1-year follow-up post adjuvant treatment at a tertiary cancer centre. Analysis of cohort 1 reveals that adherence to CEA testing is suboptimal. The next phase of this study will assess the impact of a DL, sent to patients and primary care providers outlining recommended surveillance tests and dates, on adherence rates. No significant financial relationships to disclose.
Ramifications of New Terminology for Encapsulated Follicular Variant of Papillary Thyroid Carcinoma
Authors: Juan P. Brito, Naykky M. Singh Ospina, John C. Morris
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
GPI-80 Defines Primitive Human Cord Blood-Derived CD34-Positive and Negative Hematopoietic Stem Cells
Authors: Yoshikazu Matsuoka, Keisuke Sumide, Hiroshi Kawamura, Ryusuke Nakatsuka, Tatsuya Fujioka, Yutaka Sasaki, Yoshiaki Sonoda
Journal: Blood (2015)
Breast Cancer Risk From Diet, Tobacco, and Alcohol
Authors: Randall E. Harris
Journal: JAMA (1993)

<h3>To the Editor.</h3> —A large prospective study of 89 538 nurses by Willett et al<sup>1</sup>concluded after 4 years of follow-up that moderate alcohol consumption is a risk factor for development of breast cancer. In a recent paper by the same group of investigators, additional information is given on the number of women who developed breast cancer by stratum of alcohol consumption. The purpose of this letter is to draw attention to an apparent diminishing temporal trend in the risk of breast cancer associated with alcohol in the study. The data in the Table were directly abstracted from the 1987 study by Willett et al<sup>1</sup>(Table 2, p 1176) and the 1992 study by Willett et al<sup>2</sup>(Table 4, p 2042) and show the number of cases by alcohol intake strata during years 1 through 4 and 5 through 8 of follow-up. As shown in the Table, the
A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies
Authors: Intan D.M. Azmi, Peter P. Wibroe, Lin-Ping Wu, Ali I. Kazem, Heinz Amenitsch, Seyed M. Moghimi, Anan Yaghmur
Journal: Journal of Controlled Release (2016)
Ascertaining Whether Suicides Are Caused by Infections
Authors: Lena C. Brundin, Jamie Grit
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Comparison of Out-of-Pocket Costs and Quality of Life (QOL) for Patients (pts) with Hodgkin’s Disease (HD), Indolent Non-Hodgkin’s Lymphoma (INHL) and Aggressive Non-Hodgkin’s Lymphoma (ANHL).
Authors: Narissa J. Nonzee, Sheila O. Brown, Chih-Hung Chang, Andrew M. Evens, Leo I. Gordon, Jane N. Winter, Lee Bowman, Lucie Kutikova, Charles L. Bennett
Journal: Blood (2006)
Predicting isocitrate dehydrogenase genotype in malignant glioma with multimodality imaging markers.
Authors: Biqi Zhang, Ken Chang, Shakti Ramkissoon, Shyam Kumar Tanguturi, Wenya Linda Bi, David A. Reardon, Keith L. Ligon, Brian Michael Alexander, Patrick Y. Wen, Raymond Yi-kun Huang
Journal: Journal of Clinical Oncology (2016)

2009 Background: Malignant gliomas with mutations in the isocitrate dehydrogenase (IDH) gene family confer longer overall survival relative to their IDH wild-type counterparts. Accurately determining IDH genotype pre-operatively may have both prognostic and diagnostic value that contributes to treatment decision-making. The current study used a machine-learning algorithm to generate a model predictive of IDH genotype based on multi-modal imaging and clinical features. Methods: Preoperative magnetic resonance images were obtained for 120 patients with primary grade III (n = 35) and IV (n = 85) glioma in this retrospective study. IDH genotype was confirmed for grade III (32/35, 91%) and IV (22/85, 26%) tumors by immunohistochemistry, spectrometry-based mutation genotyping (OncoMap), or multiplex exome sequencing (OncoPanel). Patients were randomly assigned to either the training (n = 90) or validation cohort (n = 30). A total of 2970 imaging features were extracted from pre- and post-contrast T1-weighted, T2-weighted, and Apparent Diffusion Coefficient map. Using a random forest algorithm, non-redundant features were integrated with clinical data to generate a predictive model for IDH genotype. Results: IDH genotype prediction using our model achieved an accuracy of 86% (specificity = 90%, sensitivity = 83%) in the training cohort and 89% (sensitivity = 84%, specificity = 89%) in the validation cohort. The misclassification error using ten-fold cross-validation in the training set was 17%. Features with the highest predictive value included patient age as well as parametric intensity, texture, and shape features. Conclusions: Using a machine-learning algorithm, we achieved accurate prediction of IDH genotype in malignant gliomas with preoperative MRI and clinical features.