tbuckley/cabot-search huggingface dataset:
Motility of Normal and Leukemic Human Lymphocytes
Authors: R SCHREK
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0842 Gastrointestinal Safety and Tolerability of Long-Term GCSB-5 of Dried Extracts of Six Herbs in Patients with Osteoarthritis: A 24 Weeks, Multi-Centers, Single Arm Phase IV Study
Authors: Y.-B. Park, C.-W. Ha, H.-S. Kyung, H.-C. Lim, S.-E. Park, H.-C. Kim, M.-C. Lee, Y.-Y. Won, C.-W. Kim, J.-G. Kim, J.-S. Kang, J.-K. Seon, S.-I. Bin
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> A previous study on GCSB-5 showed non-inferiority to Celecoxib in efficacy and safety in treating osteoarthritis, but its safety information on the gastrointestinal (GI) safety was limited to only 12 weeks. A longer term (24 weeks) study with a larger number of patients is necessary to establish the GI safety of GCSB-5. <h3>Objectives</h3> The primary goal of this study was to determine the incidence of GI disorders associated with GCSB-5. The secondary goal was to collect the GI safety data of GCSB-5 and compare them with the safety data of the previously reported Celecoxib Long-term Arthritis Safety Study (CLASS). <h3>Methods</h3> A single arm safety study of 24-week GCSB-5 for osteoarthritis patients was conducted. Then, the results of GI safety in this study were compared with those from the CLASS. This study was performed in 19 academic institutions between May 2012 and June 2013. Two GCSB-5 capsules (300 mg per capsule) were prescribed two times per day for 24 weeks. A total of 761 patients with osteoarthritis were enrolled and 756 patients took at least one dose of study drug. A total of 629 patients (82.7%) completed the 24 weeks follow-up visit. Incidence of GI disorders was the primary outcome. Incidence of GI perforation, ulcer obstruction and bleeding (PUB), and dropout due to GI complications were the major secondary outcome variables. All the suspected PUB events were forwarded to the GI event committee (GEC), consisted of GI specialist independent of investigators, for PUB diagnosis, treatment and related tests. <h3>Results</h3> The incidence of GI disorders was 23.7%. Concomitant Aspirin use did not show any significant difference in GI disorders in this study cohort. The annualized incidence rate of PUB was 0.0%. The drop-out rate due to GI disorders in GCSB-5 was 4.8%. In comparison with CLASS, GCSB-5 was significantly lower in the incidence of GI disorders (23.7% vs 31.4%, p&lt;0.001), annualized rate of PUB and gastroduodenal ulcer (0.0% vs 2.2%, p=0.004), and drop-out rate (4.8% vs 8.7%, p&lt;0.001) due to GI disorders. <h3>Conclusions</h3> This study indicated GCSB-5 was safe for osteoarthritis patients during long-term treatment. Furthermore, the safety results of GCSB-5 associated with GI disorder were comparable to Celecoxib. <h3>Acknowledgements</h3> This study was supported by Green Cross Corporation, South Korea. <h3>Disclosure of Interest</h3> None declared
AB0973 Temporomandibular Joint Arthroscopy in Juvenile Idiopathic Arthritis. Successfully Treatment with Synovial Electrocoagulation
Authors: E. Iglesias, G.-Y. Cho, E. Inarejos, R. Bou, M. Navallas, N. Rodríguez, J. Sánchez-Manubens, V. Torrente-Segarra, J. Calzada, J. Antόn
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Temporomandibular joint (TMJ) is affected in approximately 80% of Juvenile Idiopathic Arthritis (JIA) patients, usually asymptomatic. Magnetic Resonance Imaging (MRI) with contrast remains as the gold standard for its diagnosis. Main objectives of management are to control active synovitis and prevent chronic damage but nowadays there is not a consensus on how to treat these patients. TMJ arthroscopy seems to be a non-invasive technique that allows direct examination and local treatment. <h3>Objectives</h3> To review our JIA patients who have been treated with TMJ arthroscopy because of local active synovitis. Assess clinical and MRI with contrast outcome after 6 and 12 months. <h3>Methods</h3> We made a retrospective charts review of our JIA patients in whom TMJ arthroscopy had been done. Clinical symptoms and signs were evaluated as pain, maximum interincisal opening, mouth opening deviation and/or presence of microretrognatia. MRI with contrast of TMJ was done before and after arthroscopy. Activity and damage was evaluated with <i>Cron et</i><i>al</i> score. Arthroscopy was made under general anesthesia and nasotracheal intubation. We used a 1.9 mm glass lens arthroscope for small joints. If synovitis was detected local electrocoagulation was done. We made local infiltration with 1 ml of triamcinolone hexacetonide and sodic hialuronidate. <h3>Results</h3> 12 patients were included. Clinical symptoms and imaging score improved after arthroscopy in all patients. We have not complications. Not local relapse have been identified. <h3>Conclusions</h3> TMJ arthroscopy is a complex technique that allows direct joint examination. Electrocoagulation produces a synovial scar that reduce relapse with low index of complications. This technique seems to be promising in patients with TMJ active synovitis despite of systemic treatment. <h3>References</h3> Stoll ML, Sharpe T, Beukelman T, Good J, Young D, Cron RQ. Risk factors for temporomandibular joint arthritis in children with juvenile idiopathic arthritis. J Rheumatol 2012;39(9)1880-87 Vaid YN, Dunnavant FD, Royal SA, Beukelman T, Stoll ML, Cron RQ. Imaging of the temporomandibular joint in juvenile idiopathic arthritis. Arthritis Care Res 2014;66(1):47-54 <h3>Disclosure of Interest</h3> None declared
Cirrhosis
Authors: Ann R. Punnoose, Cassio Lynm, Robert M. Golub
Journal: JAMA (2012)

Jacob A. Udell, MD, MPH, FRCPC; Charlie S. Wang, MD, MSc, FRCPC; Jill Tinmouth, MD, PhD, FRCPC; J. Mark FitzGerald, MB, FRCPC; Najib T. Ayas, MD, MPH, FRCPC; David L. Simel, MD, MHS; Michael Schulzer, MD, PhD; Edwin Mak, BASc; Eric M. Yoshida, MD, MHSc, FRCPC
OC-071 Oesophageal physiology findings in 80 patients with recurrent dysphagia post-achalasia treatment: retest before retreating
Authors: JLS Ooi, R Hewett, E Yazaki, D Sifrim, P Woodland
Journal: Gut (2015)

<h3>Introduction</h3> Achalasia is a relatively rare primary oesophageal motor disorder characterised by absent peristalsis and failure of relaxation of the lower oesophageal sphincter (LOS). The standards of treatment for achalasia are pneumatic balloon dilatation and surgical myotomy. Although 85–95% success at 2 years is reported with these procedures, in the longer term, dysphagia may return in over 50%, prompting consideration of re-treatment. The definition of recurrence is often based on symptom evaluation, particularly dysphagia. Treatment of dysphagia in achalasia is targeted at the LOS, but in some patients dysphagia may be multifactorial and may not be improved by attempting to further lower LOS pressure. We aimed to evaluate the GI physiological findings of patients undergoing studies in our tertiary referral unit to investigate recurrence of dysphagia post-treatment. <h3>Method</h3> We interrogated our database for patients undergoing high resolution oesophageal manometry +/- 24-hour pH studies due to dysphagia post-treatment for achalasia between 2010–2014. We recorded achalasia subtype, LOS relaxation pressure (known as integrated relaxation pressure, or IRP), and reflux study results if performed. <h3>Results</h3> 80 eligible patients (38 female; age range 11–83 years, median 46 years) were identified with recurrent dysphagia. All had high resolution oesophageal manometry performed, and 18 patients had 24-hour pH studies due to concomitant heartburn and/or regurgitation. 52 patients had undergone at least one previous pneumatic dilatation, 23 had undergone surgical myotomy, and 5 had no response to Botox injection. 40 patients were found to have type 1 achalasia, 25 had type 2 achalasia, and 6 had type 3 achalasia. 9 patients had normal peristalsis unlikely to be consistent with a diagnosis of achalasia. 22 of the 80 patients had an IRP &gt;15 mmHg (upper range of normal). 10 patients had a very low (&lt;5 mmHg) IRP. 11 patients had pathological oesophageal acid exposure on 24-hour reflux testing. <h3>Conclusion</h3> We investigated a large cohort of patients with recurrent dysphagia post-treatment of achalasia. The most frequent achalasia subtype was type 1. Although 28% patients had high residual LOS pressures, a significant proportion of patients had findings not consistent with a need to re-treat with dilatation or myotomy (due to very low LOS pressure, gastro-oesophageal reflux disease, or possible incorrect diagnosis). These results highlight the need to carefully re-evaluate patients presenting with recurrent dysphagia after achalasia treatment before deciding on repeat therapy. <h3>Disclosure of interest</h3> None Declared.
Modification of Treatment Schedules in the Management of Advanced Mouse Leukemia with Amethopterin
Authors: Goldin, Abraham, Venditti, John M., Humphreys, Stewart R., Mantel, Nathan
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Modification of Treatment Schedules in the Management of Advanced Mouse Leukemia with Amethopterin Get access Abraham Goldin, Abraham Goldin Laboratory of Chemical Pharmacology and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar John M. Venditti, John M. Venditti Laboratory of Chemical Pharmacology and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Stewart R. Humphreys, Stewart R. Humphreys Laboratory of Chemical Pharmacology and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Nathan Mantel Nathan Mantel Laboratory of Chemical Pharmacology and Biometry and Epidemiology Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 2, August 1956, Pages 203–212, https://doi.org/10.1093/jnci/17.2.203 Published: 01 August 1956 Article history Received: 06 April 1956 Published: 01 August 1956
Medical school factors and career choice of psychiatry
Authors: F Sierles
Journal: American Journal of Psychiatry (1982)

Using questionnaires sent to training directors, the author examined the relationships between 35 medical school variables and selection of psychiatry by students. The results indicate that there are complex but significant relationships between medical school factors and choice of psychiatry. Variables most strongly predictive of recruitment are the academic rank of the director, the in-house prestige of the department of psychiatry, and the receipt of a teaching award by the director. These findings suggest that the role of the director is crucial for recruitment and that departmental efforts which augment the prestige of the department should enhance recruitment.
Male subfertility
Authors: A. Hirsh
Journal: BMJ (2003)

Abnormal semen quality or sexual dysfunction are contributing factors in about half of subfertile couples. As natural pregnancy is substantially reduced in these cases, the man should be assessed by an appropriately trained gynaecologist in a reproductive medicine clinic, or by a clinical andrologist. Subfertile men often defer consultations because they perceive subfertility as a threat to their masculinity. Consultations should help them to distinguish between fertility and virility, which may ease their anxiety. However, achievement of a wanted pregnancy is more likely to restore manly feelings.​feelings.



Table 1

Semen analysis terminology
PWE-027 Oesophageal candidiasis: does taking a biopsy affect the outcome? a dgh experience
Authors: M Stammers, D Zhu, J Shutt, S Bridger, J Jupp
Journal: Gut (2015)

<h3>Introduction</h3> Oesophageal Candidiasis (OC) is strongly associated with various immunocompromised states. We noted locally that some endoscopists feel confident in their ability to identify the condition visually at OGD, and therefore do not biopsy the oesophagus. The aim of this retrospective study was to analyse the outcomes for a cohort of patients diagnosed with OC at endoscopy to see whether oesophageal biopsy affected outcomes. <h3>Method</h3> All OGDs performed at DCH over one year (21/03/13–21/03/14) were reviewed. Patients diagnosed with OC at endoscopy were followed up. Three groups were identified: Group 1, Histology proven OC; Group 2, oesophageal histology suggesting alternative diagnosis; and Group 3, patients not biopsied. Diagnoses and patient outcomes were assessed between 10 and 22 months following the initial OGD. <h3>Results</h3> 3375 OGDs were performed. 103 patients (63 female, 40 male), mean age 72.9 years, (range 34–97 yrs) had endoscopic evidence of possible OC. 49 patients (47.5%) had an oesophageal biopsy. Only 61% of these biopsies confirmed OC (Group 1); of these patients one was subsequently diagnosed with HIV, seven took inhaled steroids, seven had cancer, one had intercurrent sepsis, one was reflux related, one had poor diabetic control, two took continuous antibiotics and ten were on a PPI. Mortality in Group 1 was 10% within one month following OGD (all were related to disseminated malignancy). 39% of biopsied patients had histology negative for candida (Group 2) with the following alternative diagnoses made histologically: 16 had reflux oesophagitis, one had HSV oesophagitis, one had eosinophilic oesophagitis and one had bisophosphonate-related oesophagitis. Mortality in Group 2 was 0%. 52.5% of patients with suspected OC did not receive a biopsy (Group 3). Four patients had contraindications to biopsy: two oesophageal varices, two were over anti-coagulated. 57% of these patients had strong risk factors for OC pre-endoscopy: 12 were on long term inhaled/oral steroid, 11 had cancer, three were acutely malnourished, two had decompensated liver disease, and two were on other immunosuppressant medication. Mortality in Group 3 was high: 42.6% in six months (Range: 0–17 months) with varied causes of death that included fungal pneumonia and colonic adenocarcinoma. <h3>Conclusion</h3> We suggest all patients with endoscopically suspected OC should be biopsied unless there are compelling reasons not to, as up to 40% of patients will have an alternative diagnosis despite similar endoscopic appearances. Histologically proven OC is often associated with immunocompromise, it is therefore important for endoscopists to advise upon further investigation, particularly in the setting of GP open access endoscopy. Our data suggest a high mortality in this group although treatable diseases may be found. <h3>Disclosure of interest</h3> None Declared.
Effects of Ionizing Irradiation Treatments on Tumor Regression
Authors: J W HOLLCROFT, M MATTHEWS
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Effects of Ionizing Irradiation Treatments on Tumor Regression Get access Joanne W. Hollcroft, Joanne W. Hollcroft Search for other works by this author on: Oxford Academic PubMed Google Scholar Marion Matthews Marion Matthews Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 527–535, https://doi.org/10.1093/jnci/14.3.527 Published: 01 December 1953 Article history Received: 16 June 1953 Published: 01 December 1953
Patients First
Authors: John Lister
Journal: New England Journal of Medicine (1980)

The government has responded to the report of the Royal Commission on the National Health Service (NHS)1 by publishing a paper2 summarizing its proposals for changes in the structure and management of the NHS in England and Wales. This document, with the imaginative title, "Patients First," is commendably brief, and, as the title indicates, the emphasis is on identifying the changes required to improve the standard of patient care. Thus, it is emphasized that the NHS exists to serve patients and that the main objective of the government is to establish a structure that will allow efficient planning and management . . .
Esophageal Hiatus Hernia
Authors: J. Murray Beardsley
Journal: New England Journal of Medicine (1956)

DURING the past ten years, the x-ray diagnosis of esophageal hiatus hernia has been made at the Rhode Island Hospital in approximately 350 cases. In 93, or over 25 per cent, surgical repair has been carried out. My own experience has been with 15 cases by the thoracic and 28 by the abdominal route, totaling 43 cases. The remaining 50 operations were carried out by 11 other surgeons. Operation was recommended only for the relief of symptoms and then only after a reasonable trial of medical therapy. It is now believed that more of these patients should be operated upon . . .
Necroptosis: Mechanisms and Relevance to Disease
Authors: Lorenzo Galluzzi, Oliver Kepp, Francis Ka-Ming Chan, Guido Kroemer
Journal: Annual Review of Pathology Mechanisms of Disease (2016)

Necroptosis is a form of regulated cell death that critically depends on receptor-interacting serine-threonine kinase 3 (RIPK3) and mixed lineage kinase domain-like (MLKL) and generally manifests with morphological features of necrosis. The molecular mechanisms that underlie distinct instances of necroptosis have just begun to emerge. Nonetheless, it has already been shown that necroptosis contributes to cellular demise in various pathophysiological conditions, including viral infection, acute kidney injury, and cardiac ischemia/reperfusion. Moreover, human tumors appear to obtain an advantage from the downregulation of key components of the molecular machinery for necroptosis. Although such an advantage may stem from an increased resistance to adverse microenvironmental conditions, accumulating evidence indicates that necroptosis-deficient cancer cells are poorly immunogenic and hence escape natural and therapy-elicited immunosurveillance. Here, we discuss the molecular mechanisms and relevance to disease of necroptosis.
Enuresis treatment with imipramine hydrochloride: a 10-year follow-up study
Authors: P M Bindelglas, G Dee
Journal: American Journal of Psychiatry (1978)

The authors followed 29 young adults who had been treated for enuresis with imipramine hydrochloride 10 years earlier. To test beliefs that enuresis is symptomatic of severe psychopathology or of urological conditions, they studied whether the treatment had been followed by psychological decompensation; an inhibition of learning; a predisposition to drug abuse; negative effects on health, growth, weight, and development; or continued urinary symptoms. None of these negative effects was present; in general the subjects were active, well-motivated, and sociable and showed no significant psychiatric symptoms. One patient still wetted but only occasionally.
Bone marrow-derived and resident liver macrophages display unique transcriptomic signatures but similar biological functions
Authors: Lynette Beattie, Amy Sawtell, Jason Mann, Teija C.M. Frame, Bianca Teal, Fabian de Labastida Rivera, Najmeeyah Brown, Katherine Walwyn-Brown, John W.J. Moore, Sandy MacDonald, Eng-Kiat Lim, Jane E. Dalton, Christian R. Engwerda, Kelli P. MacDonald, Paul M. Kaye
Journal: Journal of Hepatology (2016)
Simple Method for in Vitro Metabolic Studies Using Small Volumes of Tissue and Medium
Authors: H KEEN, J B FIELD, I H PASTAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Squamous Papilloma of the Upper Respiratory Epithelium
Authors: P LAMPERTICO, W O RUSSELL, W S MACCOMB
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal