Abstract 4836: Gene and environment interactions of height and selected candidate SNPs in prostate cancer: results from the PRACTICAL consortium.
Authors: Kenneth R. Muir, Artitaya Lophatananon, Rosalind Eeles, Graham G. Giles, Zsofia Kote Jarai, Richard M. Martin, Jong Park, Gianluca Severi, Janet Standford, Fredrick Schumacher, Sarah Stewart Brown, Ruth Travis, Fredrik Wiklund, Douglas Easton
Journal: Cancer Research (2013)

Abstract Abstract We analysed data from the PRACTICAL (PRostate cancer AssoCiation group To Investigate Cancer Associated aLterations in the genome) consortium on height and over 160 selected candidate SNP's predominantly in growth factor pathways. 12 case-control and nested case-control studies provided epidemiological data including information on height (5064 cases and 3074 controls). We present results here on the associations of height and the selected SNPs on prostate cancer risk and on their interaction. The mean height was 176.3 cm in cases and 176.9 cm in controls. Results of meta-analysis of the association between height and prostate cancer risk indicated study homogeneity and thus data were pooled to obtain pooled odds ratios (ORs). Mean and standard deviation (sd) was used to define subjects as normal (mean ±sd), short (&amp;lt;mean- sd) and tall stature (&amp;gt;mean+sd). Analyses were adjusted for age and family history of prostate cancer in first degree relatives. Height was not significantly associated with risk in shorter and taller men compared to men with a normal height: OR of 1.08 (95%CI 0.91-1.29) and 0.98 (95% CI 0.84-1.15), respectively. For the genotyping results, a log additive model was used to assess the associations between the SNPs and prostate cancer risk and the results showed that 3 SNPs (rs1509461, OR 1.09 (95%CI 1.01-1.17) in the GHR gene, rs2946834 OR 1.13 (95%CI 1.04-1.22) and rs1520220 OR 1.10 (95%CI 1.00 -1.22) in the IGF-1 gene) were significantly associated with prostate cancer after adjusting for age and family history of prostate cancer, all P-values &amp;lt;0.05. For gene and environment interaction analyses, the synergy factor estimation and an empirical Bayes method were used. Only one SNPs showed a marginal negative interaction with height in tall statured men (rs1520220 in the IGF-1 gene) with a synergy factor of 0.76, 95% CI 0.59-0.99. In summary, height did not show any significant association with prostate cancer risk. Three candidates SNP's showed modest increased risks. Overall there was little indication of an effect of height and/or its interaction with the candidate SNPs. Citation Format: Kenneth R. Muir, Artitaya Lophatananon, Rosalind Eeles, Graham G. Giles, Zsofia Kote Jarai, Richard M. Martin, Jong Park, Gianluca Severi, Janet Standford, Fredrick Schumacher, Sarah Stewart Brown, Ruth Travis, Fredrik Wiklund, Douglas Easton, The PRACTICAL CONSORTIUM. Gene and environment interactions of height and selected candidate SNPs in prostate cancer: results from the PRACTICAL consortium. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4836. doi:10.1158/1538-7445.AM2013-4836 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.