tbuckley/cabot-search huggingface dataset:
Abstract 1732: PI3K inhibition potentiates ABT-737 induced apoptosis in colorectal cancer cells independent of MCL1 downregulation or AKT/mTOR inhibition.
Authors: Danielle S. Potter, Paul J. Kelly, Olive A. Denneny, Caroline Dive, Christopher J. Morrow
Journal: Cancer Research (2013)

Abstract Background Colorectal cancer (CRC) is the third most common cancer and is a leading cause of morbidity worldwide. The five year survival rate of patients with advanced or metastatic CRC is less than 5%, identifying the need for new and improved therapies in the treatment of advanced and metastatic CRC. Phosphoinositide 3-kinase (PI3K) signaling has been implicated in several hallmarks of cancer, such as sustained proliferation, resisting cell death and invasion, and is frequently deregulated in CRC via a mutation of effectors such as PIK3CA, PIK3R1 and PTEN, making it an attractive therapeutic drug target. Despite this, inhibition of PI3K signaling does not cause cell death in CRC cells. Furthermore, CRC cells are relatively resistant to the BH3 mimetic ABT-737, which directly targets the BCL2 family of proteins inducing apoptosis via the mitochondrial pathway. Therefore, we investigated whether combining PI3K inhibitors and ABT-737 in CRC cells might synergise to induce apoptosis. Results PI3K inhibition enhanced ABT-737 induced apoptosis by 2.3-4.5 fold and reduced expression levels of Mcl-1, an established resistance biomarker for ABT-737. PI3K inhibition enhanced ABT-737-induced apoptosis a further 1.4-2.4 fold in CRC cells with siRNA depleted Mcl-1 suggesting contributory mechanisms additional to Mcl-1 down regulation. PI3K inhibition increased levels of Bcl-xL bound BimEL independently of Mcl-1 depletion. Further investigations are being carried out to determine whether this is the cause of increase ABT-737 sensitivity. ABT-737-induced apoptosis was unaffected by inhibition of PI3K downstream effectors AKT and mTOR. A siRNA library screen has been conducted to identify proteins downstream of PI3K which affect ABT-737 sensitivity and the results will be reported. Conclusions These data reveal a PI3K inhibition enhanced, ABT-737 driven apoptosis that occurs via Mcl-1, AKT and mTOR independent mechanism(s) consistent with increased association of BimEL and Bcl-xL. Further work is ongoing to elucidate the molecular mechanisms that underpin enhanced response to this BH-3 mimetic in CRC. Citation Format: Danielle S. Potter, Paul J. Kelly, Olive A. Denneny, Caroline Dive, Christopher J. Morrow. PI3K inhibition potentiates ABT-737 induced apoptosis in colorectal cancer cells independent of MCL1 downregulation or AKT/mTOR inhibition. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1732. doi:10.1158/1538-7445.AM2013-1732
The Windshield Wiper and Scintillating Scotoma
Authors: H. A. Johnson
Journal: JAMA (1967)

<h3>To the Editor:—</h3> Vision is a chemical process and, though rapid, it takes time. It takes 1/10 of a second from visual impression of danger to application of one's foot to the brake pedal. If at the crucial moment the retinal image is "burned out" by a flash of light from your car's windshield wiper, much might happen at 60 mph. (88 ft/sec) in that 1/10 of a second. The National Traffic Safety Agency has recommended that nonreflective surfaces be used on windshield wiper arms on cars built after 1968, but a lot can happen before then. For the interim, I have a suggestion, something I've been doing for years: Get a can of flat black enamel and an inexpensive child's watercolor brush. The enamel sticks surprisingly well to the chrome even after two years. Life is so wonderfully full, I'll do anything that might prolong it—even painting that lovely
AB0447 Behcet’s disease: is there an association between gender and severity?
Authors: F. Izmailova, M. Kudaev, E. Nasonov, Z. Alekberova
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> It is postulated by some authors that neurological disturbances, thrombosis, ocular lesions and other severe clinical signs of Behcet’s disease (BD) are most common in males (m) than in females (f). <h3>Objectives</h3> To compare the frequency of main clinical features of BD in males and females from Dagestan ethnic cohort. <h3>Methods</h3> 85 patients with BD (ISBD criteria) were enrolled (m=63, mean age 31±9,8 years, f=22, mean age 29±8,6 years. M/F ratio was 2,8:1. Disease duration in m was 11,27±7,4 years, in f - 7,8±7,1 years. <h3>Results</h3> The main features of BD in m and f are summarized and compared in Table 1. Oral aphthosis occurred with the same frequency in m and f and was 98%. Uveitis, retinal vasculitis and skin lesions were more often in men than in women with BD. Moreover, severe symptoms of BD, such as vasculo-Behcet, or venous thrombosis developed more frequently in males. There was no difference in the frequency of central nervous system and gastro-intestinal damage between m and f with BD. <h3>Conclusions</h3> It is obvious that disease course is more serious in males than in females with BD from Dagestan ethnic cohort. Possibly there is an influence of HLA-B51 positivity. This antigen appeared to be positive in 75% of males and 47% of females. <h3>Disclosure of Interest</h3> None Declared
INFLUENCE OF LEFT BUNDLE BRANCH BLOCK IN ASSESSMENT OF MYOCARDIAL BLOOD FLOW FROM RUBIDIUM 82 POSITRON EMISSION TOMOGRAPHY IMAGING
Authors: Andrea Falcao, William Chalela, Maria Giorgi, Rodrigo Imada, Jose Soares Jr, Marisa Izaki, Roberto Kalil-Filho, Jose C. Meneghetti
Journal: Journal of the American College of Cardiology (2015)
Moving Forward With a “Second Generation” Lymphoma Vaccine
Authors: Susan Jenks
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Moving Forward With a “Second Generation” Lymphoma Vaccine Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 2, 20 January 1993, Pages 91–92, https://doi.org/10.1093/jnci/85.2.91 Published: 20 January 1993
Ventral Hernia Resulting in Increased Fluorodeoxyglucose Uptake on Positron Emission Tomographic Imaging
Authors: Alan Rebenstock, Hongming Zhuang, Marc Hickeson, Charles Lau, Abass Alavi
Journal: Clinical Nuclear Medicine (2002)

REBENSTOCK, ALAN M.D.; ZHUANG, HONGMING M.D., Ph.D.; HICKESON, MARC M.D; LAU, CHARLES M.D.; ALAVI, ABASS M.D. Author Information
Extensive Extraskeletal Osteosarcoma in the Liver and Abdomen as Demonstrated by Bone Scintigraphy
Authors: ROZINA MAREDIA, DAVID L. WARD, ALBERT J. MORENO, ALAN L. CARPENTER
Journal: Clinical Nuclear Medicine (1997)

A 66-year-old man had abdominal pain and ascites. Eight months previously, he had an exploratory laparotomy in which a 21-pound extraskeletal retroperitoneal osteosarcoma was resected. Recent bone scintigraphy demonstrated extensive peritoneal and hepatic metastatic foci. Computed tomography demonstrated calcified metastases within the liver and within the peritoneum.
Intermittent abdominal pain due to pancreatic pseudocyst hemorrhage diagnosed by endoscopic ultrasound
Authors: C. Rodrigues, J. Pontes, N. Pignatelli, V. Nunes, J. Deus
Journal: Endoscopy (2013)

A 36-year-old man presented to the emergency room with a 3-week history of intermittent, intense epigastric pain. He had an episode of alcoholic pancreatitis 8 months before, which was complicated by a 9-cm pseudocyst located in the body and tail of the pancreas. The patient did not attend the follow-up appointment. He denied having fever, vomiting, weight loss, or gastrointestinal hemorrhage, and claimed to be abstemious. Physical examination was normal, except for epigastric tenderness. Blood tests including hemogram, amylase, lipase, and inflammatory markers were unremarkable. Computed tomography (CT) scan showed that the pseudocyst remained stable in size and contained a small amount of high-attenuation debris ([Fig. 1]); there were signs of left portal hypertension determined by compression of the splenic vein. Endoscopic ultrasound (EUS) revealed a vessel within the cyst, evidence of intracystic hemorrhage, and hemosuccus pancreaticus ([Fig. 2]). The patient remained hemodynamically stable but his hemoglobin level dropped by 1.5 g/dL. No pseudoaneurysm or contrast extravasation was detected on abdominal angiography. Emergent surgery was proposed, but the patient refused further intervention and was discharged on request. A few weeks later, the patient returned to the emergency room due to abdominal pain. CT demonstrated a vessel within the cystic wall ([Fig. 3]). The patient underwent surgery with ligation of the vessel and drainage of the cyst; he remains asymptomatic at 6-month follow-up.
Abstract 4722: Evaluation of common genetic variation in 1,300 cancer-related candidate genes and endometrial cancer risk
Authors: Hannah P. Yang, Amanda Spurdle, Mia M. Gaudet, Louise A. Brinton, Jolanta Lissowska, Beata Peplonska, Mark Sherman, Penny Webb, Kaltin Ferguson, Tracy O'Mara, ‘ ANECS, Stephen Chanock, Montserrat Garcia-Closas
Journal: Cancer Research (2010)

Abstract Background: Endometrial cancer genetic susceptibility studies have largely focused on genes in the sex steroid hormone, checkpoint, and cell-cycle pathways, but single nucleotide polymorphisms (SNPs) in genes involved in other cancer-related pathways might also influence risk. Methods: We investigated the association between endometrial cancer risk and ∼29,000 SNPs in over 1,300 cancer-related candidate genes in the inflammation, metabolism, and other carcinogenic pathways in the Polish Endometrial Cancer Study (PECS), a population-based investigation involving 417 cases and 407 controls. TagSNPs were located in the respective gene or within 10 kb or 5 kb downstream; had a minor allele frequency (MAF) &amp;gt;5% in various ethnic groups; and were not represented by a current tag SNP in linkage disequilibrium (LD; r2&amp;gt;0.80). We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using unconditional logistic regression, adjusting for age (5-year categories). The most significant finding was followed up in the Australian National Endometrial Cancer Study (ANECS), a population-based case-control study of 815 cases and 822 controls. Results: In PECS, we found three SNPs in two loci associated with endometrial cancer risk at P&amp;lt;0.0001. Two highly correlated SNPs in IQGAP1, rs2601207 (OR = 0.65; 95% CI: 0.53 - 0.81, P trend = 6.0 × 10−5) and rs6496677 (0.66; 0.54 - 0.81, P trend = 8.0 × 10−5), were associated with a decreased risk. In addition, a variant in UBE3A, rs4445877, was associated with increased risk (1.53; 1.24 - 1.90, P trend = 9.0 × 10−5). We followed up the rs2601207 association in ANECS and observed a non-significantly decreased risk (0.90; 0.77 - 1.05, P trend = 0.18). The pooled per allele OR was 0.81 (95% CI: 0.72 - 0.92), P trend = 0.001); however, there was evidence for heterogeneity by study (P-heterogeneity = 0.01). Conclusion: Data from PECS suggests associations between endometrial cancer risk and variants in IQGAP1, a gene that is a key mediator in several cellular processes related to carcinogenesis, and UBE3A, encoding ubiquitin protein ligase 3A involved in the degradation of cancer-associated proteins such TP53. The association with IQGAP1 was not confirmed in a larger study population; and further studies are needed to follow up other potential associations between endometrial cancer risk and cancer candidate genes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4722.
Curious Radioactivity in the Lower Abdomen on Bone Scintigraphy
Authors: SEOK TAE LIM, MYUNG-HEE SOHN, SOON-A. PARK
Journal: Clinical Nuclear Medicine (2000)

A 44-year-old woman had Tc-99m MDP bone scintigraphy for breast cancer staging that showed lesions of abnormally intense accumulation of radiotracer in suprapubic and infrapubic areas along with urinary bladder activity. After voiding, the bladder and infrapubic accumulation disappeared, but the suprapubic activity persisted. A subsequent abdominopelvic computed tomograph revealed that the suprapubic radioactivity corresponded to the urinary bladder, which was displaced in the anterosuperior direction by a huge uterine myoma.
Acute pancreatitis: rare complication of retrograde single-balloon enteroscopy
Authors: W. Yip, K. Lok, L. Lai, K. Li, K. Li, M. Szeto
Journal: Endoscopy (2009)

A 46-year-old woman with chronic renal disease was diagnosed as having pulmonary tuberculosis. She was passing fresh melena intermittently. Upper endoscopy was unremarkable and colonoscopy, which was carried out four times, only revealed small cecal ulcers and fresh blood coming from the small bowel. A retrograde (per rectal) single-balloon enteroscopy (SBE) was carried out. The balloon was inflated when the enteroscope was still in the colon, for assisting in terminal ileal intubation. A large ulcer was found in the distal ileum, 50 cm proximal to the ileocecal valve ([Fig. 1]).
Resurrection of a Stem-Cell Funding Barrier — Dickey–Wicker in Court
Authors: George J. Annas
Journal: New England Journal of Medicine (2010)

Embryo research was born political. Expressions of shock and surprise at the August 23 ruling of federal district court judge Royce Lamberth enjoining federal funding of stem-cell research — which was based largely on his reading of an amendment to an appropriations bill — are thus not terribly persuasive.1 The amendment, known as the Dickey–Wicker amendment, provides that no federal funds can be expended by the National Institutes of Health (NIH) for "(1) the creation of a human embryo or embryos for research purposes; or (2) research in which a human embryo or embryos are destroyed, discarded, or knowingly subjected . . .
1254 KRUPPEL-LIKE FACTOR 6 SPLICE VARIANT 3 (KLF6-SV3) - THE REDOX SENSITIVE SPLICE VARIANT OF KLF6 EXPRESSED IN NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Authors: G.L. Patman, K.-Y. Hui, Q.M. Anstee, H.L. Reeves
Journal: Journal of Hepatology (2012)
Abstract 3218: Interrogating the role of NOX4 in colon cancer metastasis.
Authors: Kerry M. Bauer, Steven Buechler, Amanda B. Hummon
Journal: Cancer Research (2013)

Abstract Colon cancer is a major cause of cancer-related deaths worldwide. Adjuvant chemotherapy significantly reduces mortality in stage III colon cancer; however, it is only marginally effective in stage II patients. Molecular biomarkers are used to partition tumors into a poor prognosis group that is likely to metastasize and a good prognosis group that has a higher probability to be relapse-free. These biomarkers for relapse risk are of clinical interest, and lead to insight into how a tumor progresses to metastasis. There is increasing evidence that cancer of the ascending (right-side) colon is different from the descending (left-side) colon. There are site-specific differences in histological and molecular characteristics and different signaling pathways have been shown to dominate progression to relapse in right and left-side colon cancer. We have observed that the genes altered in expression between the poor prognosis and good prognosis tumors vary significantly depending on whether the malignancy originates on the right or left side of the colon. We have identified NADPH oxidase 4 (NOX4) to be highly predictive of relapse in stage II and stage III left-side colon cancer where elevated expression of NOX4 is correlated with relapse. Furthermore, NOX4 expression is greatly elevated in the human colon cancer derived metastatic cell line SW620 compared to human cell lines derived from primary adenoma or carcinoma colon tumors. NOX4 silencing using RNA interference results in decreased levels of reactive oxygen species (ROS). The NOX family of genes has been implicated in cancer development in several types of cancer while overproduction of ROS has been implicated in tumor metastasis. We are exploring the newly identified role of NOX4-mediated ROS generation in metastatic colon cancer. To investigate the underlying molecular mechanism we are analyzing the effect of NOX4 silencing via RNA interference and NOX4 inhibition using pharmacological NOX inhibitors on global protein expression patterns in metastatic-derived SW620 cells. Proteomic changes are being assessed by iTRAQ labeling and mass spectrometry. Bioinformatics and cluster analysis will be used to identify the functional role of redox responsive and ROS regulative proteins in colon cancer metastasis. The role of NOX4 as a prognostic biomarker in colon cancer makes it an important target for research in cancer biology and therapeutics. Citation Format: Kerry M. Bauer, Steven Buechler, Amanda B. Hummon. Interrogating the role of NOX4 in colon cancer metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3218. doi:10.1158/1538-7445.AM2013-3218
Platelet Activation in Unstable Coronary Disease
Authors: Desmond J. Fitzgerald, Louis Roy, Francesca Catella, Garret A. FitzGerald
Journal: New England Journal of Medicine (1986)

Pathological and clinical studies have suggested that platelets have a role in the pathogenesis of unstable angina and myocardial infarction. However, the relation of platelet activation to episodic ischemia in patients with unstable angina is unknown. We assessed the biosynthesis of thromboxane and prostacyclin as indexes of platelet activation in patients with stable and unstable coronary disease by physicochemical analysis of metabolites in plasma and urine. Prostacyclin biosynthesis was markedly elevated in patients with acute myocardial infarction and correlated with plasma creatine kinase (r = 0.795; P less than 0.001). The largest rise in thromboxane synthesis was observed in patients with unstable angina, in whom 84 percent of the episodes of chest pain were associated with phasic increases in the excretion of thromboxane and prostacyclin metabolites. However, 50 percent of such increases were not associated with chest pain, possibly reflecting silent myocardial ischemia. These data indicate that platelet activation occurs during spontaneous ischemia in patients with unstable angina. The increment in prostacyclin biosynthesis during such episodes may be a compensatory response of vascular endothelium that limits the degree or effects of platelet activation. If so, biochemically selective inhibition of the synthesis or action of thromboxane A2 would be desirable in the treatment of unstable angina. In contrast, thromboxane inhibitors or antagonists would not be expected to be effective in patients with chronic stable angina, in whom there was no increase in the formation of thromboxane A2.
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT) IN PSYCHIATRY.
Authors: R. A. OʼConnell, R. L. Van Heertum, A. R. Holt, D. M. Rostenthal, S. B. Billick, A. G. Gonzalez
Journal: Clinical Nuclear Medicine (1987)

O'Connell, R. A.; Heertum, R. L. Van; Holt, A. R.; Rostenthal, D. M.; Billick, S. B.; Gonzalez, A. G. Author Information
Anti-Cancer Drug Origins: Truth Is Stranger Than Fiction
Authors: S. Jenks, N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Anti-Cancer Drug Origins: Truth Is Stranger Than Fiction Get access Susan Jenks, Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 3, 2 February 1994, Pages 173–174, https://doi.org/10.1093/jnci/86.3.173 Published: 02 February 1994
Abstract 872: Skin cancers in African albinos: A cause for public concern
Authors: Samuel A. Ademola, Olayinka A. Olawoye, Odunayo M. Oluwatosin, Ayodele O. Iyun
Journal: Cancer Research (2010)

Abstract Purpose: Skin cancers are uncommon in the black Africans and as such there is little or no formal preventive program against skin cancer in most parts of Africa. In Albinos who live in tropical Africa however, skin cancers are not uncommon and their effects could be devastating. The aim of this report therefore is to evaluate the occurrence of skin cancers in albinos and to highlight the factors that make skin cancers in them a public health issue. Methods: All patients with clinical suspicion of skin cancers presenting to a major tertiary center in Nigeria were referred to the plastic surgery division of the hospital for evaluation. The chart of all albinos referred to this division between 1989 and 2009 were reviewed. Analysis was done with the aid of Statistical Package for the Social Sciences (SPSS) computer software. Results: There were 32 patients comprising 20 males and 12 females. Most of the patients were either unemployed or engaged in a low income earning occupation. The mean duration of symptoms at the time of presentation was 21.3 months. Many had multiple lesions at presentation with an average of 3 lesions per patient. The average diameter of the lesions was 8.8cm. Over 80% of the lesions were ulcerated and were located in the head and neck region. Majority of the patients had associated lymph node and surrounding contiguous tissues involvement and therefore requires major reconstructive surgery following tumor excision. Conclusion: Skin cancers constitute a major health concern in albinos who live in tropical Africa. Majority of the patients present with advanced disease that require major reconstructive surgery for disease control. There is need for institution of educational programs on preventive measures and early medical consultation in order to reduce the tumor burden in this region. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 872.
PAPEL DE LA ECOENDOSCOPIA EN EL DIAGNÓSTICO DE LESIONES QUÍSTICAS DE PÁNCREAS: EXPERIENCIA EN UNA UNIDAD DE ENDOSCOPIA
Authors: M Maraver Zamora, C Ortiz Moyano, P Guerrero Jiménez, M Romero Gómez
Journal: Endoscopy (2011)

Introducción: Con la mejora de las técnicas de imagen, las lesiones quísticas pancreáticas han resultado ser mucho más frecuentes de lo que cabría esperar. La ultrasonografia endoscópica (USE) y la punción-aspiración con aguja fina (PAAF) guiada por USE, han demostrado incrementar la sensibilidad en su diagnóstico y la diferenciación entre lesiones quísticas benignas y potencialmente malignas.
Upregulated Mirna 21 in Kras Mutated Patients is Related to Prognosis in Resectable Non-Small Cell Lung Cancer
Authors: S. Gallach, S. Calabuig-Fariñas, E. Jantus-Lewintre, D. Montaner, E. Escorihuela, A. Blasco, R. Guijarro, C. Camps
Journal: Annals of Oncology (2015)
P882 COMBINED OR NOT COMBINED LIVER/KIDNEY TRANSPLANTATION FOR SYMPTOMATIC POLYCYSTIC LIVER DISEASE: SINGLE CENTER LONG-TERM OUTCOME EXPERIENCE
Authors: F. Temmerman, L.J. Ceulemans, D. Monbaliu, R. Aerts, J. van Pelt, T. Darius, D. Kuypers, J. Pirenne, F. Nevens
Journal: Journal of Hepatology (2014)