tbuckley/cabot-search huggingface dataset:
Presidential Commission Seeks Greater Funding for Breast Cancer Research
Authors: S. Jenks, T. Parkins
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Presidential Commission Seeks Greater Funding for Breast Cancer Research Get access Susan Jenks, Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar Troy Parkins Troy Parkins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 23, 1 December 1993, Pages 1902–1903, https://doi.org/10.1093/jnci/85.23.1902 Published: 01 December 1993
PTU-078 Delays in the diagnosis and management of patients with suspected sphincter of oddi dysunction
Authors: E J Lunn, F Gohar, P Basumani, M Karajeh, K Kapur
Journal: Gut (2012)

Introduction Sphincter of oddi dysfunction (SOD) is difficult to diagnose and treat. Biliary manometry is considered to be the gold standard for diagnosing SOD but is not widely available. A significant number of patients, that we think are likely to have sphincter oddi dysfunction, present to our hospitals with recurrent upper abdominal pain. They have multiple investigations, recurrent A+E attendances and repeated admissions without a clear diagnosis or definitive treatment. Our aim was to identify this patient group in order to streamline their investigations and allow definitive treatment at an early stage, prevent readmission and save resources. Methods A retrospective case note review of patients across three hospitals in South Yorkshire, in whom the final diagnosis was SOD based on their clinical presentation and investigations. Results We reviewed 40 case notes in total. 88% of patients were female with a median patient age of 40 (18–75 years) Patients on average presented to A+E 6 times (0–50), median number of inpatient admissions was 4 (0–20) with additional outpatient clinic appointments. 70% (28/40) of patients have previously undergone cholecystectomy, with 100% continuing to have similar pain to that prior to surgery. The most common provisional diagnosis at presentation was bile duct stones (38%). Median duration of symptoms was 3 years (range 5 months-23 years). 35% (14/40) of patients initially presented to the surgeons. 100% of patient had abdominal USS (1–5) and 63% had undergone at least one OGD. All patients had a MRCP (range 1–4), 17 (43%) patients had a CT abdomen (0–4) and 12 (30%) patients underwent a HIDA scan. Patients were categorised into SOD type 1 (22%), type 2 (56%) or type 3 (22%) on their clinical presentation and investigations. 28% (7/40) of patient had a trial of Botox, 48% (19/40) underwent ERCP and biliary sphincterotomy with 53% (10/19) having symptomatic improvement. The remainder were managed on medial therapy. Conclusion There is a significant group of patients, who have recurrent abdominal pain, recurrent admissions, undergo multiple investigations and trials of medical therapy without a definitive diagnosis being made. In addition, these patients are often subjected to invasive interventions such as ERCP and sphincterotomy with the potential risk of serious complications. This audit highlights the need for a designated service to streamline work-up and management of these patients: both to reduce cost and to improve outcomes. Competing interests None declared.
Infection after Cardiovascular Surgery
Authors: Jay S. Goodman, William Schaffner, Harold A. Collins, Edward J. Battersby, M. Glenn Koenig
Journal: New England Journal of Medicine (1968)

A prospective study of 72 patients undergoing cardiovascular surgery showed that postoperative infections occurred in 20 - three after 31 nonbypass and 17 after 41 cardiopulmonary bypass procedures. Postoperative fever and leukocytic response did not help to identify the presence of infection, but infected patients tended to have lower white-cell counts and more juvenile polymorphonuclear leukocytes. Prophylactic antibiotic regimens consisting of placebo, penicillin-streptomycin or oxacillin were administered in a double-blind manner. The placebo treatment was eliminated after two patients on this regimen were found to have pneumococcal endocarditis. The antibiotic regimens did not appear to alter the frequency of postoperative infection in this small group of patients, but the specific organisms responsible for major infections may have been determined by the prophylactic regimen employed.
Failure of Association of Premature Rupture of Membranes with Respiratory-Distress Syndrome
Authors: M. Douglas Jones, Laurence I. Burd, Watson A. Bowes, Frederick C. Battaglia, Lula O. Lubchenco
Journal: New England Journal of Medicine (1975)

Records on 16,458 consecutive births were examined to determine associations between the respiratory-distress syndrome of the newborn and cesarean section, maternal diabetes, ante-partum hemorrhage, toxemia of pregnancy, low one-minute Apgar scores and prolonged rupture of fetal membranes. Groups of infants were compared by four-week gestational age blocks. One-minute Apgar scores of less than 5 and of less than 8 were associated with a significant (p < 0.05) increase in the incidence of respiratory-distress syndrome at gestational ages beyond 30 weeks. Cesarean section was associated with a significant increase after 34 weeks of gestation. There was no association between the syndrome and toxemia of pregnancy, ante-partum hemorrhage or prolonged rupture of fetal membranes. These data do not support the hypothesis that there is a lower incidence of the respiratory-distress syndrome in infants born after prolonged rupture of fetal membranes. (N Engl J Med 292:1253–1257, 1975)
AB0880 Differences in education, employment status and reason of unemployment between european and non-european patients with spondylarthritis fulfilling ASAS criteria (axial, peripheral or both) and having associated psoriasis:
Authors: E. Roussou, D. Lunda Ngandu, S. Intzes
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To assess differences in the level of education, employment status (working, not working) and reason of unemployment between European (E) and non-European (nE) patients living in the same area and suffering from spondylarthritis fulfilling ASAS criteria (axial, peripheral or both) and having associated psoriasis. <h3>Methods</h3> A structured validated questionnaire administered to patients attending Rheumatology-Dermatology outpatients' clinic between 2004 and 2008. The ASAS criteria applied retrospectively. The level of education assessed as: no schooling, primary school, secondary school, college or technical skills and higher education. Patients were asked whether they were on employment or not. If unemployed they were asked to state whether they were unemployed solely due to arthritis, partly due to arthritis, for reasons other than arthritis. <h3>Results</h3> From a total of 134 patients with SpA 87 were European (64.9%) and 47 (35%) non European, 4 patients had axial disease (3E, 1 nE), 130 had peripheral disease (75 E, 38nE) 17 had both axial and peripheral disease (9E, 8nE). Table shows education, employment, unemployment and reason for unemployment in the total group, in the E and nE group. There was no difference in the educational status (p=0.9) and employment status (p=0.9), between E and nE, There was statistical difference in the unemployment group (p&lt;0.05)in that more nE were indented to work and more E were retired and unable to work. In the reason for unemployment more nE were unemployed due to arthritis 37.9% vs 28% and more E were unemployed for reasons other than arthritis 30% vs 6.9% p&lt;0.001 <h3>Conclusions</h3> There was no difference in the educational status and employment status, between E and nE, There was statistical difference in the unemployment group (p&lt;0.05)in that more nE were indented to work and more E were retired and unable to work. In the reason for unemployment more nE were unemployed due to arthritis and more E were unemployed for reasons other than arthritis. <h3>Disclosure of Interest</h3> None Declared
1289 INHIBITION OF microRNA-21 ATTENUATES NON ALCOHOLIC STEATOHEPATITIS IN MALE LOW-DENSITY LIPOPROTEIN RECEPTOR KNOCKOUT (LDLR−−) MICE
Authors: P.-E. Rautou, X. Loyer, J. Scetbun, N. Colnot, C.L. Guérin, M. Romain, J.-L. Paul, P. Bedossa, C. Boulanger, V. Paradis, A. Tedgui
Journal: Journal of Hepatology (2013)
PTU-010 Does patient satisfaction differ between bowel cancer screening and symptomatic patients?
Authors: A Ignjatovic, S Sivanesan, C Fraser, B P Saunders, N Suzuki, M Vance, S Thomas-Gibson
Journal: Gut (2010)

<h3>Introduction</h3> Bowel cancer screening (BCSP) began in England in 2006. Patients found to have a positive faecal occult blood test undergo a colonoscopy performed by an accredited colonoscopist. In contrast to “symptomatic” patients referred for a colonoscopy, those within BCSP first have a 45-min pre-assessment appointment with a specialist screening practioner (SSP). The same SSP then follows the patient throughout their episode, attending the colonoscopy and personally following up the patient. This is in contrast to the more fragmented care routinely offered to patients. The aim of this study was to assess whether there was any difference in patient satisfaction between these two patient groups. <h3>Methods</h3> Between Jan and March2009, 100 consecutive patients (50 routine diagnostic and 50 BCSP colonoscopies), were given a questionnaire to complete at home following their procedure. The questionnaire addressed three domains – pre, during and post procedure experiences. Fisher9s exact test was used to compare the satisfaction responses between two groups. <h3>Results</h3> The overall response rate was 76/100, 76% (42 in BCSP and 34 diagnostic group). Although there was no difference in the overall level of satisfaction between the two groups, 4/30 (13%) of patients having diagnostic colonoscopy reported not having been given adequate explanation of the risk compared to no patients within BCSP (p=0.03). 6/24 (25%) of patients in the routine colonoscopy group felt they needed more sedation compared to 0/30 (0%) of patients in the BCSP group (p=0.005). Similarly, the level of discomfort reported was higher in diagnostic group compared to BCSP, with 14/33 (42%) diagnostic patients reporting a “quite or extremely uncomfortable procedure” compared to only 4/41 (10%) in the BCSP, p=0.004. 39/40 (97%) of patients in the BCSP felt there were given adequate explanation of findings compared to 21/32 (64%) of those having routine colonoscopy, p&lt;0.001. <h3>Conclusion</h3> There are differences in satisfaction between BCSP patients and those having routine diagnostic colonoscopy, particularly relating to degree of comfort during and explanation given after the procedure. The reasons for this maybe multifactorial (presence of SSPs, accredited colonoscopists, asymptomatic vs symptomatic patients) however improvements in pre and post procedural care should be addressed to ensure an equal quality of service is offered to all patients.
THE ADDITIVE DIAGNOSTIC, PROGNOSTIC AND THERAPEUTIC VALUE OF SPECT IMAGING OVER EXERCISE ELECTROCARDIOGRAPHY ALONE IN PATIENTS WITH A NORMAL BASELINE ELECTROCARDIOGRAM
Authors: Saurabh Malhotra, Ravi Sharma, Deepak Kumar Pasupula, Mukul Khanna, Prem Soman
Journal: Journal of the American College of Cardiology (2014)
The Use of the Rice Diet in the Treatment of Hypertension in Nonhospitalized Patients
Authors: Andrew W. Contratto, Miriam B. Rogers
Journal: New England Journal of Medicine (1948)

THIS report covers the first six months of a study of a group of ambulatory or nonhospitalized patients with hypertension who were treated with the rice diet. With the work of Kempner1 2 3 4 as a guide but unlike his series in which all but a few patients were initially confined to a hospital, our patients were not hospitalized. So far as possible, nothing was changed in the daily routine of the patient except the diet. If he was ambulatory and working, this activity was continued. Patients who, when first started on the regime, were inactive because of their illness, continued on . . .
DIAGNOSTIC ACCURACY OF CT ANGIOGRAPHY (CTA) FOR CRITICAL PATHOLOGIC FEATURES IN ANOMALOUS AORTIC ORIGIN OF THE CORONARY ARTERIES (AAOCA) IN CHILDREN: A COMPARATIVE STUDY WITH SURGERY IN A SINGLE CENTER
Authors: Rajesh Krishnamurthy, Prakash Masand, Siddharth Jadhav, Wei Zhang, Silvana Molossi, Kristen Sexson, Dean McKenzie, Charles Fraser, Carlos Mery
Journal: Journal of the American College of Cardiology (2015)
Abstract LB-77: The Closing of the Every Woman Counts Program in California and Our Efforts to Reopen It
Authors: Sammantha McDonald
Journal: Cancer Research (2011)

Abstract The California Collaborative of Susan G. Komen for the Cure includes the seven California affiliates located in Sacramento, San Francisco, Fresno, Los Angeles, Inland Empire, Orange County and San Diego. The Collaborative was originally formed to share best practices and synergies, but has since included public policy issues in its initiatives. The ‘Every Woman Counts’ program was administered by California's Department of Public Health and provided breast and cervical cancer testing, diagnosis and treatment to uninsured women 40 years and older. The Public Policy Committee of the Collaborative worked very hard with the state's elected officials to help helped draft new legislation, propose an audit of the program, and lobby Capitol Hill. Advocates worked with the governor's health staff to ask for the capitol building to be lit pink to help raise breast cancer awareness. Supporters also spoke with anyone who would listen about the importance of this program for the insured and the lives that could potentially be lost if breast cancer went undetected. As a result of their efforts, the Collaborative found several supportive members in the state's legislature. The organization's representatives managed to pass legislation in late August to reinstate the ‘Every Woman Counts’ program. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-77. doi:10.1158/1538-7445.AM2011-LB-77
Starch Blockers — Their Effect on Calorie Absorption from a High-Starch Meal
Authors: George W. Bo-Linn, Carol A. Santa Ana, Stephen G. Morawski, John S. Fordtran
Journal: New England Journal of Medicine (1982)

It has been known for more than 25 years that certain plant foods, such as kidney beans and wheat, contain a substance that inhibits the activity of salivary and pancreatic amylase. More recently, this antiamylase has been purified and marketed for use in weight control under the generic name "starch blockers." Although this approach to weight control is highly popular, it has never been shown whether starch-blocker tablets actually reduce the absorption of calories from starch. Using a oneday calorie-balance technique and a high-starch (100 g) meal (spaghetti, tomato sauce, and bread), we measured the excretion of fecal calories after normal subjects had taken either placebo or starch-blocker tablets. If the starch-blocker tablets had prevented the digestion of starch, fecal calorie excretion should have increased by 400 kcal. However, fecal calorie excretion was the same on the two test days (mean ±S.E.M., 80±4 as compared with 78±2). We conclude that starch-blocker tablets do not inhibit the digestion and absorption of starch calories in human beings. (N Engl J Med. 1982; 307:1413–6.)
FRI0150 Chronic Back Pain (CBP) Characteristics Associated with the Presence of Sacroiliitis on Magnetic Resonance Imaging (MRI) in Patients with Suspected Axial Spondyloarthritis (AXSPA): Results from the Esperanza Cohort: Table 1
Authors: V. Navarro-Compán, R. Almodόvar, A. Hernández, E. Beltrán, E. de Miguel, P. Zarco
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> CBP is nowadays the starting point for the ASAS classification criteria for axSpA. Later, two possible entry criteria based on complementary examinations (imaging and HLA-B27) are considered. CBP is a very prevalent symptom, so it is necessary to identify those characteristics more likely resulting in a positive complementary test. <h3>Objectives</h3> To evaluate which inflammatory characteristics of CBP are associated with the presence of sacroiliitis on MRI in patients with suspected axSpA. <h3>Methods</h3> Baseline dataset from the EsPeranza cohort (&lt;45 years old, symptoms duration 3-24 months and with inflammatory back pain -IBP- or asymmetrical arthritis or spinal/joint pain plus ≥1 SpA features) was used. Data from 326 patients with axial symptoms who underwent sacroiliac joint (SIJ) MRI were analysed. Odds ratio were estimated for the association between IBP characteristics (morning stiffness, improve with exercise and not with rest, alternating buttock pain, insidious onset, awakening at 2nd half of night and good response to NSAID) and their different combinations with a positive SIJ MRI (ASAS definition). <h3>Results</h3> A total of 130 (40%) patients had sacroiliitis.Table shows the results for the association between the individual and combined IBP characteristics with a positive MRI. Alternating buttock pain (OR=3.43; p&lt;0.001), insidious onset (OR=2.15; p&lt;0.05) and awakening at 2nd half of the night (OR=1.71; p&lt;0.05) were associated with a positive MRI. The combination of these characteristics or the addition of alternating buttock pain to the ASAS definition of IBP were the most specific (OR=3.08; p&lt;0.001; Spe 92% and OR=6.17; p&lt;0.001; Spe 94%, respectively). <h3>Conclusions</h3> Alternating buttock pain is the IBP characteristic most strongly associated with a positive SIJ MRI in patients with suspected axSpA. The inclusion of this characteristic in the current definition of IBP could improve the efficiency of SIJ MRI. <h3>Acknowledgements</h3> The EsPeranza Program has been supported by an unrestricted grant from Pfizer <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1768
AB0450 Myeloid Dendritic Cells and Plasmacytoid Dendritic Cells as Possible Target for the Immunotherapy in Patients with Rheumatoid Arthritis
Authors: S.A. Falaleeva, V.V. Kurilin, N.S. Shkaruba, O.A. Chumasova, A.E. Sizikov, S.V. Sennikov
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Recently, dendritic cells (DC) are considered as an object to create a new therapeutic strategy in rheumatoid arthritis (RA), since they are involved in all stages of the inflammatory process. States of phenotypic and functional characteristics of DCs will depend on the possibility of their use as a therapeutic modulator and the targeted object to other biological treatment strategies [1]. <h3>Objectives</h3> To research the phenotypic and functional properties of myeloid (mDC) and (pDC) plasmacytoid DC in peripheral blood (PB) of patients with RA. <h3>Methods</h3> Blood samples were obtained from 10 patients during the exacerbation of RA. Analysis of the DC target populations contents was performed using flow cytometer "BD FACS Aria". Phenotypic characterization of immature mDC (Lin-HLA-DR+CD123-CD11c+) and pDC (Lin-HLA-DR+CD123+CD11c-) in the whole blood was estimated by the positive expression of CD80, CD83, CCR7, IL-10, IL-4, IL-12, IFN-α. To determine the ability of DC to mature stimulants R848 and lipopolysaccharide (LPS E.colli 0114: B4) were used. <h3>Results</h3> The relative content of PB in the RA patients mDC (1%) and healthy donors (1.02%) did not differ, then the amount of pDC in RA patients (0.1%) was significantly lower than in healthy donors (0.6%). DC of RA patients have low levels of expression of CD80 CD83, both the mDC and pDC. In RA patients on pDC, an increase in the expression of CCR7 (62%) compared with normal (30.5%). In the PB of RA patients compared with healthy donors, shows the increased IL- 12, IFN-α and decreased IL- 4 and IL- 10 expression mDC and pDC [2]. <h3>Conclusions</h3> In PB of RA patients formation of unbalance as in cytokines as well in subsets of dendritic cells is observed. DC of patients with RA are characterized by less mature state wherein pDC have higher migration potential compared to healthy donors. Estimated data may lead to development of DC-targeting therapy in autoimmune diseases. <h3>References</h3> Prevosto C., Goodall J.C., Hill Gaston J.S. Cytokine secretion by pathogen recognition receptor-stimulated dendritic cells in rheumatoid arthritis and ankylosing spondylitis. J.Rheumatol. 2012; 39(10): 1918-28. Van Krinks C.H., Matyszak M.K., Gaston J.S. Characterization of plasmacytoid dendritic cells in inflammatory arthritis synovial fluid. Rheumatology (Oxford). 2004; 43(4): 453-460. <h3>Acknowledgements</h3> Work is supported by grants of the FTP "Scientific and Scientific-Pedagogical Personnel of the Innovative Russia in 2009-2013" (Agreement No. 8790) <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1136
Many State Health Departments Begin Major Cancer Control Efforts
Authors: M. E. Newman
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Many State Health Departments Begin Major Cancer Control Efforts Get access Michael E. Newman Michael E. Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 14, 19 July 1989, Pages 1053–1055, https://doi.org/10.1093/jnci/81.14.1053 Published: 19 July 1989
The Value of 18F-FDG PET/CT in Diagnostic Procedure of Intravascular Large B-Cell Lymphoma Presenting Fever of Unknown Origin and Pulmonary Hypertension as an Initial Manifestation
Authors: Fengyu Wu, Zhenguang Wang, Xiaoming Xing, Mingming Yu, Bin Shi
Journal: Clinical Nuclear Medicine (2016)

A 57-year-old man presented with fever of unknown origin and pulmonary hypertension. An 18F-FDG PET/CT scan was performed to evaluate the source of fever, which showed diffuse, homogeneously increased FDG uptake in both lungs, which prompted the transbronchial lung biopsy. The pathological examination from biopsy specimen demonstrated intravascular large B-cell lymphoma.
A Day in Its Life: The Cancer Information Service in Miami
Authors: C. K. Wittenberg
Journal: JNCI Journal of the National Cancer Institute (1989)

A Day in Its Life: The Cancer Information Service in Miami Get access Clarissa K. Wittenberg Clarissa K. Wittenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 15, 2 August 1989, Pages 1128–1130, https://doi.org/10.1093/jnci/81.15.1128 Published: 02 August 1989