tbuckley/cabot-search huggingface dataset:
Compounding the Ordeal of ALS
Authors: David Rabin, Pauline L. Rabin, Roni Rabin
Journal: New England Journal of Medicine (1982)

IT has been three years since my first symptoms suggested a diagnosis of amyotrophic lateral sclerosis (ALS). The pain and anguish of this illness are known to most physicians and are an inevitable accompaniment of the disease, but there are other unpleasant aspects that are avoidable. In this article I want to relate my personal story and to emphasize the extraordinary change that my illness brought about in my interrelations with fellow physicians.I turned 45 in January 1979. I was then director of endocrinology at the Vanderbilt Medical Center, and my research in the areas of metabolism and reproduction . . .
Everolimus combined with R-CHOP-21 for new, untreated, diffuse large B-cell lymphoma (NCCTG 1085 [Alliance]): safety and efficacy results of a phase 1 and feasibility trial
Authors: Patrick B Johnston, Betsy LaPlant, Ellen McPhail, Thomas M Habermann, David J Inwards, Ivana N Micallef, Joseph P Colgan, Grzegorz S Nowakowski, Stephen M Ansell, Thomas E Witzig
Journal: The Lancet Haematology (2016)
Serum creatine phosphokinase levels in patients meeting the St. Louis research diagnostic criteria for schizophrenia
Authors: D S Schubert, K Brocco, F T Miller, M Patterson
Journal: American Journal of Psychiatry (1982)

In this study 18 patients with a research diagnostic criteria diagnosis of schizophrenia had a mean initial serum creatine phosphokinase level significantly higher than that of 36 control subjects with other RDC diagnoses. There were no corresponding elevations in the serum levels of nondrinking alcoholics or patients with primary or secondary affective disorders. The authors suggest that increased creatine phosphokinase levels in schizophrenic patients may be due to a sudden increase in the substance in the dopaminergic or limbic system due to increased muscle membrane permeability or to sympathetic nervous system or adrenergic dominance.
PWE-119 Complex symptom burden and unmet need in end-stage liver disease
Authors: S Kriese, K Bristowe, WM Prentice, MA Heneghan, IJ Higginson, FEM Murtagh
Journal: Gut (2015)

<h3>Introduction</h3> End-stage liver disease (ESLD) is now the third most common cause of death in those of working age in England and Wales. Despite this, little is known about the palliative care needs of this population, including symptom burden. This study aims to describe the prevalence and severity of symptoms in end-stage liver disease. <h3>Method</h3> A cross-sectional survey of adults with ESLD in two UK centres as part of a wider longitudinal study of symptoms, quality of life and other concerns. English-speaking adult patients with Childs Pugh C cirrhosis of any aetiology were eligible for the study. Patients were inelibible if on active antiviral therapy or had persistent grade II (or above) hepatic encephalopathy. Patients were recruited from inpatient and outpatient settings in a tertiary liver unit and a regional liver unit in the southeast of England. Symptoms were assessed using the Intergrated Palliative Care Outcome Scale (IPOS). The IPOS is a ten item questionnaire assessing physical symptoms, emotional, information and support needs in patients with advanced illness. Prevalence and severity of symptoms presented as counts and proportions. Bivariate analysis performed using ordered logistic regression in STATA SE 12.1. <h3>Results</h3> We present preliminary data from 27 participants; 67% were male with median age of 55 yrs (IQR 48–60 yrs), mean MELD 17.7 (SD 3.9) and UKELD 53.7 (SD 3.4). Disease aetiology included alcohol (12), PSC (5), NASH (4), PBC (2), viral (2), and other causes (2). Participants reported a median of 8 symptoms of any severity (range 2–13). 75% reported one or more ‘severe’ or ‘overwhelming’ symptom (s). The prevalence of severe/overwhelming symptoms largely mirrored the overall prevalence of each individual symptom. The three most common severe symptoms were weakness and lack of energy (46%), drowsiness (34%) and shortness of breath (15%). 24% of particpants reported feeling anxious about their illness most or all of the time. Total number of reported symptoms of any severity and counts of severe/overwhelming symptoms were not associated with age, gender, aetiology, MELD or UKELD. <h3>Conclusion</h3> This study demonstrates that patients with ESLD have considerable symptom control needs. These needs are not associated with disease severity as assessed by conventional prognostic scores. Patients with ESLD and may benefit from the earlier integration of specialist palliative care services alongside standard hepatological care. <h3>Disclosure of interest</h3> None Declared.
Cameroon's MDR-TB treatment programme jeopardised by cross-border migration
Authors: Jürgen Noeske, Jean-Louis Abena Foe, Christopher Kuaban
Journal: European Respiratory Journal (2016)

We read with interest in a recent issue of the European Respiratory Journal , a paper by Lönnroth et al . [1] entitled. "Towards tuberculosis elimination: an action framework for low-incidence countries". The authors highlight cross-border migration as a major challenge for tuberculosis (TB) control efforts and their action framework pleads for strong international partnerships for reaching global TB elimination targets. To further comment on the challenges posed by cross-border migration, we here report on a recent experience of Cameroon's National TB Programme (NTP). MDR-TB treatment programme can be jeopardised by cross-border migration as seen in Cameroon <http://ow.ly/WHbxw>
Serum Glutamic-Oxalacetic Transaminase in Coronary Artery Disease
Authors: BERNARD H. OSTROW, DANIEL STEINBERG, HOWARD E. TICKTIN, GEORGE N. POLIS, JOHN M. EVANS
Journal: Circulation (1956)

The results of serial glutamic-oxalacetic transaminase (GOT) assays in 201 cases in which coronary artery disease was suspected are correlated with the clinical, laboratory, and electrocardiographic changes. In 95 per cent of the cases diagnosed as myocardial infarction on the basis of clinical and electrocardiographic evidence there was an elevation of serum GOT. On the other hand, in 12 per cent of the cases in which clinical and electrocardiographic findings were negative or equivocal with regard to myocardial infarction, there was an elevated serum GOT. In 18 cases that were autopsied the correlation between acute myocardial necrosis and serum GOT elevation was 100 per cent.
Whole Exome Sequencing In Relapsed Pediatric T-ALL: Progression Into Relapse Is Characterized By An Increased Number Of Somatic Mutations and a Conservation Of Mutations In Leukemogenic Driver Genes
Authors: Joachim Kunz, Tobias Rausch, Obul R Bandapalli, Martina U. Muckenthaler, Adrian M Stuetz, Martin Stanulla, Martin Schrappe, Rupert Handgretinger, Smadar Avigad, Jan Korbel, Andreas E. Kulozik
Journal: Blood (2013)
Hypersensitivity to carbon dioxide in panic disorder
Authors: L A Papp, R Goetz, R Cole, D F Klein, F Jordan, M R Liebowitz, A J Fyer, E Hollander, J M Gorman
Journal: American Journal of Psychiatry (1989)

Seven male panic patients did not panic but were significantly more sensitive to steady-state carbon dioxide inhalation than five male normal control subjects. The male patients' hypersensitivity to carbon dioxide was unrelated to current state of anxiety or acute panic.
AB0970 Improvement of the Long-Term Outcome in Greek Adult Patients with Juvenile Idiopathic Arthritis in the 21St Century
Authors: D. Dimopoulou, M. Trachana, P. Pratsidou-Gertsi, P. Sidiropoulos, A. Theodoridou, F. Kanakoudi, A. Garyfallos
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> During the last decade there is evidence of a rising improvement regarding the long-term outcome of patients with Juvenile Idiopathic Arthritis (JIA). <h3>Objectives</h3> To compare long-term outcome between patients with disease onset before and after 2000. <h3>Methods</h3> Patients (pts) ≥18 years with an established JIA, a disease onset ≥5 years and no history of &gt;6 months care from external rheumatologists, were enrolled in the study. Clinical, laboratory and radiographic examination were performed at the last follow-up visit, 17.2 years post-diagnosis. The outcome variables were: radiographic damage assessed by the total modified Sharp/van der Heijde Score (TmSvdHS), articular and extra-articular damage by Juvenile Arthritis Damage Index (JADI-A and JADI-E) and physical ability by the Health Assessment Questionnaire-Disability Index (HAQ-DI). In the multivariate analysis, possible explanatory variables were characteristics present at onset and active disease duration within 5 years of onset. <h3>Results</h3> A total of 102 (72 F) pts were enrolled. The age at disease onset (mean ± SD) was 7.7±4 yrs, the interval from onset to last visit 17.2±6.7 yrs and the pts9 current age 25±5.9 yrs. 28 patients were diagnosed after 2000 (Group 1) and 74 patients before 2000 (Group 2). The 2 Groups didn9t differ in demographic and clinical characteristics, as gender, type of disease onset and ACPA positivity. At the last follow-up visit, Group 1 had better TmSvdHS, better JADI-A and better JADI-E score as compared to Group 2 (p&lt;0.001, p&lt;0.001, p=0.003, respectively). In contrast, HAQ-DI score did not differ between the 2 Groups (p=0.55) but disease duration within 5 yrs of onset was longer in Group 2 (p=0.02). Prognostic factors for joint damage were disease duration [B (95%CI) 2.114 (0.206,4.022), p=0.03], cumulative % time spent in a state of active disease [B (95%CI) 0.007 (0.004,0.011), p&lt;0.001] and cumulative time spent in a state of clinical remission off medication over the entire disease course [B (95%CI) -0.667 (-1.048,-0.286), p=0.001]. <h3>Conclusions</h3> Pts diagnosed after 2000, had a better long term outcome as compared to those before 2000. Despite the difference in disease duration, active disease duration within 5 years of onset proved to be a critical prognostic factor, probably reflecting the availability of biologics nowadays and the treat-to-target strategies. <h3>References</h3> Minden K. Adult outcomes of patients with juvenile idiopathic arthritis. Horm Res 2009; 72:20-25. <h3>Disclosure of Interest</h3> None declared
Depression in borderline personality disorder: lifetime prevalence at interview and longitudinal course of symptoms
Authors: J C Perry
Journal: American Journal of Psychiatry (1985)

The author compared a group of patients with borderline personality disorder with groups of subjects with antisocial personality and bipolar II illness. The lifetime prevalence at interview of DSM-III major depression was high in all groups. Chronic depression demonstrated a specific relationship to borderline psychopathology. Prospectively, borderline psychopathology predicted high levels of depressive and anxiety symptoms. This relationship was reversed for depressive symptoms in patients with antisocial personality disorder, suggesting that when borderline and antisocial personality disorders occur together, some features may arise that differentiate patients with both disorders from those with either disorder alone.
Activity of the Mammary Tumor Agent in Mice of Different Ages and Their Progeny&lt;xref ref-type="author-notes" rid="FN1"&gt;2&lt;/xref&gt;
Authors: John J. Bittner
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Activity of the Mammary Tumor Agent in Mice of Different Ages and Their Progeny Get access John J. Bittner John J. Bittner Division of Cancer Biology, Department of Physiology, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 1, January 1957, Pages 65–76, https://doi.org/10.1093/jnci/18.1.65 Published: 01 January 1957 Article history Received: 12 July 1956 Published: 01 January 1957
1-Carbamyl-2-Phenylhydrazine Tumorigenesis in Swiss Mice. Morphology of Lung Adenomas2
Authors: Bela Toth, Hidesuke Shimizu
Journal: JNCI Journal of the National Cancer Institute (1974)

A solution of 0.25% 1-carbamyl-2-phenylhydrazine was administered daily for life in the drinking water of randomly bred Swiss mice. In the treated animals the incidence of lung tumors was 78% in females and 69% in males, whereas the corresponding incidences in the untreated controls were 21 and 23%, respectively. Light, transmission, and scanning electron microscopic examination of the induced lung lesions revealed adenomas composed of alveolar cells, type B. Ultrastructural characteristics in the cytoplasm included lamellar and osmiophilic bodies, membrane-bound lakelike structures, dense particles, and myelin figures. Free cell surface characteristics were described and illustrated. The results proved, for the first time, the tumorigenicity of this substituted hydrazine which is known to possess antipyretic action.
Sleep-related penile tumescence as a function of age
Authors: I Karacan, R L Williams, J I Thornby, P J Salis
Journal: American Journal of Psychiatry (1975)

The authors conducted a study of nocturnal penile tumescence (NPT) in 125 healthy males aged 3 to 79 by means of EEG recordings to provide normative data on how general the phenomenon is, its range of charateristics, and how it is related to man's sexual function. The results indicate that NPT occurs consistently in a healthy male population, that its expression is significantly affected by age, that it is related to stage of psychosexual development, and that it is worthy of further investigation. Clinical experience indicates that it is a useful, objective method of discriminating among various types of biogenic and psychogenic impotence.
Rapid Worsening of Esophageal Varices in a Patient with Small Hepatocellular Carcinomas after Percutaneous Ethanol Injection Therapy
Authors: Y Terui, H Togashi, T Matsuo, M Aoki, Y Takeda, T Takeda, H Mitsuhashi, H Watanabe, K Saito, T Saito, T Takahashi, H Shinzawa
Journal: Endoscopy (2001)

Figure 1 a, b A 64-year-old woman with liver cirrhosis C was admitted to our hospital for the treatment of hepatocellular carcinomas (HCCs). Percutaneous ethanol injection therapy was performed for HCCs and complete tumor necrosis was achieved. A month after the final percutaneous ethanol injection, upper gastrointestinal endoscopy revealed exacerbation of the esophageal varices. The size and shape of the varices had enlarged remarkably and red spots were observed as indicated by the arrow heads. VA, varix A; VB, varix B; VC, varix C.
B-Cell Characteristics of Human Peripheral and Cord Blood Lymphocytes Transformed by Epstein-Barr Virus
Authors: Paul K. Pattengale, Richard W. Smith, Paul Gerber
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article B-Cell Characteristics of Human Peripheral and Cord Blood Lymphocytes Transformed by Epstein-Barr Virus Get access Paul K. Pattengale, Paul K. Pattengale Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard W. Smith, Richard W. Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Gerber Paul Gerber Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1081–1086, https://doi.org/10.1093/jnci/52.4.1081 Published: 01 April 1974 Article history Received: 05 October 1973 Accepted: 05 December 1973 Published: 01 April 1974
Psychologic and behavioral disturbance among epileptic children treated with barbiturate anticonvulsants
Authors: M Ferrari, G Barabas, W S Matthews
Journal: American Journal of Psychiatry (1983)

From their studies of epileptic children, the authors found that barbiturate anticonvulsants have several unexpected psychologic and behavioral effects. They suggest that clinicians dealing with depression in epileptic patients consider the possibility that barbiturate anticonvulsants may be a contributing factor.
One Thousand Consecutive Contact Lens Cases
Authors: H H BOYD
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evidence for a permanent presence of schistosomiasis in Corsica, France, 2015
Authors: Antoine Berry, Judith Fillaux, Guillaume Martin-Blondel, Jérôme Boissier, Xavier Iriart, Bruno Marchou, Jean François Magnaval, Pierre Delobel
Journal: Eurosurveillance (2016)

We present a case of acute schistosomiasis acquired in Corsica after bathing in the Cavu River during the summer of 2015. The diagnosis was made following epidemiological, laboratory and serological assessments. After a previous outbreak of urogenital schistosomiasis during the summer of 2013, when more than 120 infections were diagnosed, this further case indicates transmission was still effective in 2015, thus suggesting a permanent presence of schistosomiasis in Corsica.
Effects of behavioral skills training and schedule of nicotine gum administration on smoking cessation
Authors: M G Goldstein, R Niaura, M J Follick, D B Abrams
Journal: American Journal of Psychiatry (1989)

Eighty-nine smokers were randomly assigned to four nicotine gum treatments for smoking cessation: behavioral treatment plus a fixed schedule of nicotine gum, behavioral treatment plus an ad lib schedule, education plus a fixed schedule, and education plus an ad lib schedule. The four treatment conditions produced similar rates of abstinence (40.9% to 58.3%) at the end of 11 weeks of treatment. However, at 6-month follow-up, the subjects who had received behavioral treatment had a significantly better abstinence rate (36.7%) than those receiving education (17.5%). Nicotine gum schedule had no effect on treatment outcome.
Tardive dyskinesia: are first signs reversible?
Authors: F Quitkin, A Rifkin, L Gochfeld, D F Klein
Journal: American Journal of Psychiatry (1977)

Although tardive dyskinesia, a serious and sometimes irreversible side effect of antipsychotic drug use, is becoming increasingly common, there is still considerable confusion concerning the course of the syndrome. The authors observed 12 psychiatric patients with tardive dyskinesia from the inception of the syndrome. They found that first symptoms rarely persisted if antipsychotics were discontinued and concluded that the length of time symptoms have persisted prior to drug discontinuation, not age at onset, may be the major variable determining reversibility of the syndrome.
Remarks on "molecular markers and stem-cell transplants: are they made for each other?".
Authors: F Cabanillas
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.9.2472 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7666109 Remarks on "molecular markers and stem-cell transplants: are they made for each other?". F CabanillasxF CabanillasSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.9.2472 PDF "Remarks on "molecular markers and stem-cell transplants: are they made for each other?".." Journal of Clinical Oncology, 13(9), pp. 2472–2473© 1995 by American Society of Clinical Oncology
PTU-240 Comparison of outcomes of abdominal and colorectal surgery in patients with left ventricular assist devices versus heart transplants
Authors: MX Traa, A Asban, N Melnitchouk
Journal: Gut (2015)

<h3>Introduction</h3> As survival of patients with left ventricular assist devices (LVADs) and cardiac transplantation improves, surgeons must increasingly decide whether and when to operate on them. <h3>Method</h3> We conducted a retrospective review of abdominal and colorectal operations performed on patients with heart transplants or LVADs at a tertiary care hospital in Boston, MA between 2003–2013. Data were collected on comorbidities, anticoagulation and immunosuppression status, intra-and post-operative complications, need for blood product transfusion, type of surgery performed, 24-hr and thirty day mortality, and time post-transplant or LVAD insertion. Statistical testing for significance was done using the two-sided Fisher’s exact test. <h3>Results</h3> Over the 11-year period, 13 patients with LVADs and 32 patients with heart transplants underwent a total of 67 colorectal (22%) and other abdominal (78%) operations. The median time between LVAD insertion or heart transplant and abdominal surgery was 175 days and 765 days respectively. There was a tendency towards a higher proportion of elective (vs emergency) cases in heart transplant (74%) vs LVAD patients (53%) (p = 0.13). LVAD patients were more likely to be anticoagulated, and had an 18% incidence of postoperative bleeding, with a significantly greater proportion of patients requiring blood transfusion within the first postoperative week (47%) compared to transplant patients (8%) (p = 0.001). Venous thromboembolic (VTE) events were also significantly more common in the LVAD group (21%) vs transplant group (0%) (p = 0.01). Subgroup analysis revealed the incidence of VTE was significantly decreased in the LVAD group bridged for surgery (p = 0.0008). Despite all transplant patients being on immunosuppression medication, and 46% on steroids, there was no statistically significant difference in surgical site infections between the transplant (6%) and LVAD (12%) groups (p = 0.59). Mortality within 24 h tended to be higher in the LVAD group (13%) vs transplant group (0%), with borderline significance (p = 0.06). 30-day mortality was significantly higher in the LVAD group (21%) vs transplant group (0%) (p = 0.01). <h3>Conclusion</h3> Surgical outcomes were better in patients who had undergone heart transplantation compared to those with LVADs, especially with respect to the need for postoperative transfusion, the incidence of VTE, and 24-hr and 30-day mortality. The observed tendency to perform fewer elective cases in LVAD patients compared to transplant patients may be a reflection of clinical intuition of this finding. Surgeons should assess these higher-risk patients on a case-by-case basis. Surgeons should also bridge anticoagulation for LVAD patients whenever possible to reduce the risk of VTE. <h3>Disclosure of interest</h3> None Declared.
Outcomes in 50 Patients with Advanced Gastric Cancer Treated in Phase I Trials: the Ncche Experience
Authors: Akihito Kawazoe, Kohei Shitara, Yasutoshi Kuboki, Hideaki Bando, Wataru Okamoto, Takashi Kojima, Nozomu Fuse, Takayuki Yoshino, Toshihiko Doi, Atsushi Ohtsu
Journal: Annals of Oncology (2014)
Technical Performance Score Predicts Resource Utilization in Congenital Cardiac Procedures
Authors: Meena Nathan, Kimberlee Gauvreau, Mihail Samnaliev, Al Ozonoff, Kathy Jenkins, Lisa Bergersen, Jean Connor, Frank A. Pigula, Steven D. Colan, John E. Mayer, Pedro J. del Nido
Journal: Journal of the American College of Cardiology (2016)