tbuckley/cabot-search huggingface dataset:
FRI0179 Comparative Effectiveness of Biologic Disease Modifying Anti-Rheumatic Drug Therapy in US Veterans with Rheumatoid Arthritis: Table 1
Authors: G.W. Cannon, T. He, C.-C. Teng, J. Leng, C.-C. Lu, D. Tang, N. Shah, D.J. Harrison, B. Sauer
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Comparison of effectiveness of biologic disease modifying anti-rheumatic drugs (DMARDs) in clinical practice may provide important insight into their clinical benefit in patients with rheumatoid arthritis (RA). A recent validated algorithm is available to evaluate clinical effectiveness in US veterans.<sup>1</sup> <h3>Objectives</h3> To compare the effectiveness of abatacept (ABA), adalimumab (ADA), etanercept (ETN), infliximab (INF), and rituximab (RIT) in US veterans with RA and assess the reasons for failure. <h3>Methods</h3> National Veterans Affairs (VA) pharmacy and administrative databases were evaluated on all US veterans initiating biologics from Jan 1, 2008 to Jan 1, 2012 and followed until Jan 1, 2013 to allow ≥1-year of follow-up per patient. The analysis was limited to the first treatment course beginning ≥180 days after VA enrollment, consistent with a new biologic initiation and agents with ≥100 dispensing episodes. The validated effectiveness algorithm is based on administrative claims data. Medications were classified as effective if all of the following criteria were met: high adherence, Medication Possession Ratio (MPR) &gt;80% for self-injected biologic or receiving at least 80% of the minimum recommended number of infusions, no biologic dose increase, no switching biologics, no new non-biologic disease modifying antirheumatic drugs (DMARD), &lt;2 intra-articular injections, no new glucocorticoids or glucocorticoid dose increases.<sup>1</sup> <h3>Results</h3> During the study period, 19,244 RA patients were treated with biologics; 9,979 had 1-year of follow-up and 4,704 patients had their first course beginning &gt;180 days after VA enrollment. <h3>Conclusions</h3> Algorithm-defined effectiveness was higher for injectable tumor necrosis factor inhibitors (ADA, ETN) than for infused biologics, ABA, INF, and RIT. Major factors associated with lower effectiveness were low adherence and biologic dose escalation. <h3>References</h3> Curtis et al. Arthritis Res Ther, 2011, 13(5), R155. <h3>Acknowledgements</h3> Research funded by VA Research Program and Immunex Corporation, a wholly owned subsidiary of Amgen Inc., and by Wyeth, which was acquired by Pfizer Inc. in October 2009. <h3>Disclosure of Interest</h3> G. Cannon: None declared, T. He: None declared, C.-C. Teng: None declared, J. Leng: None declared, C.-C. Lu: None declared, D. Tang Shareholder of: Amgen, Employee of: Amgen, N. Shah Shareholder of: Amgen, Employee of: Amgen, D. Harrison Shareholder of: Amgen, Employee of: Amgen, B. Sauer: None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1903
Gastric band cutter to remove a migrated gastric band
Authors: A. Herreros de Tejada, J. Calleja, M. Jiménez, V. Rojo, C. Santander, J. Rial, R. García, J. Chennat, A. Picardo, L. Abreu
Journal: Endoscopy (2012)

Laparoscopic adjustable gastric banding is a popular method in bariatric surgery. A silicone ring is adjusted in the gastric fundus to create a smaller proximal compartment [1]. Intragastric migration of a gastric band is a common complication that might require surgical treatment.
Case 3-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Philip C. Amrein, Carolyn C. Compton
Journal: New England Journal of Medicine (1990)

Presentation of CaseA 66-year-old woman was admitted to the hospital because of Waldenström's macroglobulinemia, with severe weakness, diarrhea, and gastrointestinal bleeding.There was a long history of abuse of tobacco and alcohol. The patient was otherwise in a stable state of health until two months before admission, when fatigue, myalgia, arthralgia, and a low-grade fever developed, with occasional night sweats. Diarrhea, weakness, and peripheral edema soon appeared, and she was admitted to another hospital. Physical examination showed splenomegaly without hepatomegaly; there was prominent peripheral edema. The hematocrit was 26 percent; the mean corpuscular volume (MCV) was 114 μm3 per . . .
Abstract 1767: Gene expression signatures as predictors of chemotherapeutic response in breast cancer
Authors: Marcia V. Fournier, Katherine J. Martin
Journal: Cancer Research (2010)

Abstract The purpose of this study is to evaluate a novel 22-gene signature as a predictor of response to chemotherapy in breast cancer. The extent of residual viable tumor following chemotherapy is the most important predictor of long-term outcome in breast cancer. It is essential to identify patients who will not respond to chemotherapy to avoid ineffective therapies as well as unnecessary side effects. The rate of complete pathologic response to chemotherapy is relatively low, ranging from 3% to 27% of patients. Much work has been performed to predict chemotherapy responsiveness, but, as of yet, no test is effective and widely used in the clinic. Gene expression signatures are a multifaceted approach to characterizing disease states. They offer the potential to tailor a chemotherapy regimen to an individual patient. Here we compare the ability of multiple gene signatures, including the 70-gene prognostic signature (MammaPrint) and the 22-gene signature among others, to accurately predict response to multiple different regimens of primary chemotherapy in breast cancer. Predictive ability is compared in independent microarray datasets totaling approximately 157 breast cancer patients treated with primary chemotherapy. Sensitivity, specificity, and overall accuracy were evaluated by receiver operating characteristics (ROC) graphs, a technique for visualizing, organizing, and selecting classifiers based on their performance. Results show that the 22-gene signature accurately predicts response to multiple primary chemotherapies (p&amp;lt;0.05). Importantly, the 22-gene signature outperformed other signatures with highly significant p-values in all datasets tested. This signature potentially represents a clinically useful method to select a personalized chemotherapy regimen for breast cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1767.
AB0939 Anti TNF therapy and malignancy in psoriatic arthritis and ankylosing spondylitis: The biosparegister
Authors: K. de Vlam, I. Westhovens, P. Verschueren
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Tumor necrosis factor alpha (TNF-a) is a key member of a large family of cytokines and receptors that are crucial to cellular organization. The development and use of biological therapy in the last several years, such as the TNF-a antagonists, has opened new perspectives for the treatment of patients with spondyloarthropathy (SpA). Nevertheless, it is now clear that TNF plays a paradoxical role in the evolution and treatment of malignant disease and the occurrence of malignancy has been considered as a possible adverse event in anti-TNF therapy. <h3>Objectives</h3> To report systematically the malignancy incidence seen in a large cohort of patients with SpA treated with one or more anti-TNF therapies and to compare the results with the malignancy incidence in the global population. <h3>Methods</h3> 231 patients with SpA that were treated with one or more anti-TNF therapies were included in a prospective observational cohort study for a total of 1199,83 patient years follow-up. The primary outcome for this study was the incidence of malignancy after starting anti-TNF treatment. Incidence rates were compared with the incidence rates of malignancy in Belgium by the Belgian Cancer Registry in the age group of 45-50 year old population in 2006. <h3>Results</h3> In our study population, 6 out of 231 patients (2,6%) developed a malignancy after the start of anti-TNF treatment. The overall incidence rate of malignancy is 500,1 per 100000 patient years. Incidence rate for malignancy in female SpA patients is more than two-fold higher than that in males, but standardised incidence ratios are similar for male and female patients and indicate a higher incidence of malignancy in our study population compared to the control population <h3>Conclusions</h3> Allthough there are certain study weaknesses, we can see a tendency towards a higher incidence of malignancy in SpA patients that are treated with anti-TNF therapy. It is still not clear whether this is a disease-related risk or a treatment-related risk. <h3>Disclosure of Interest</h3> None Declared
Case 15-2003
Authors: Carolyn M. Fleming, Jo-Anne O. Shepard, Eugene J. Mark
Journal: New England Journal of Medicine (2003)

Presentation of CaseA 47-year-old man was evaluated in the pulmonary clinic because of waxing and waning pulmonary lesions several years after treatment for seminoma.The patient had been well until five years earlier, when a left testicular seminoma was diagnosed. A left radical orchiectomy was performed; there was no evidence of lymphatic or blood-vessel invasion, and the resection margins, epididymis, and spermatic cord were free of tumor. A computed tomographic (CT) study of the chest, performed after the oral administration of contrast material, disclosed slight anterior pericardial thickening, with no axillary, hilar, or mediastinal lymphadenopathy or evidence of pulmonary . . .
Standards for foundation trust status will not be lowered even if trusts fail the test, says Monitor
Authors: A. O'Dowd
Journal: BMJ (2012)

Background/Aim: This study was designed to provide further evidence for the interactions between hydrogen sulfide (H<sub>2</sub>S) and nitric oxide (NO) in ischemia/reperfusion (I/R) injury. Materials and Methods: Rat hearts were studied with the Langendorff technique using the H<sub>2</sub>S donor sodium hydrosulfide (NaHS, 40 μM) and the cystathionine gamma-lyase (CTH or CSE) inhibitor DL-propargylglycine (PAG, 1 mM). NO synthase inhibitor L-NG-nitroarginine methyl ester (L-NAME, 30 mg/kg, 7 days) was administered before the isolation. The hearts were homogenized for biochemical and molecular analysis. Results: NaHS reversed I/R-induced cardiac performance impairment, increased tissue nitric oxide production and decreased tissue markers for cardiac injury, while L-NAME inhibited these effects. The expression of CTH was increased with PAG, which was suppressed by L-NAME. Conclusion: H<sub>2</sub>S and NO increase each other9s production suggesting their interaction and cooperation in cardioprotection against I/R injury.
Occult Spinal Dysraphism
Authors: Hsien-Yi Chiu, Yi-Hua Liao
Journal: New England Journal of Medicine (2014)

A 3-year-old girl was referred for the removal of excess hair on the back, which had been present since birth, for cosmetic reasons. Physical examination revealed a tuft of coarse, dark hair in the midline of the back, just above the natal cleft.
Inhibition of Granulocyte Adherence by Ethanol, Prednisone, and Aspirin, Measured with an Assay System
Authors: Rob Roy MacGregor, Phillip J. Spagnuolo, Arnold L. Lentnek
Journal: New England Journal of Medicine (1974)

A simple, rapid, in vitro assay was developed to study granulocyte adherence, an important component of the inflammatory reaction. Heparinized whole blood is filtered through nylon fiber packed in Pasteur pipettes, and the percentage of granulocytes adhering is calculated. Test variability from morning to evening, before and after meals, and on successive days is less than 10 per cent. In vitro exposure of whole blood to ethanol concentrations varying from 100 to 1000 mg per 100 ml caused a dose-dependent, significant inhibition of adherence (16–87 per cent, p<0.05), but incubation with sodium salicylate (5 to 50 mg per 100 ml) or hydrocortisone sodium succinate (500 to 3000 μg per 100 ml) had no effect. In all volunteers receiving 40 mg of prednisone or 1.2 g of aspirin, impaired adherence developed, suggesting that glucocorticoids and salicylates may affect adherence in vivo by inducing an inhibitor. The anti-inflammatory effect of salicylates, hydrocortisone and ethanol may be secondary to their inhibition of granulocyte adherence. (N Engl J Med 291:642–646, 1974)
Phenotypic heterogeneity in<i>PIK3CA</i>-related overgrowth spectrum
Authors: H. Vahidnezhad, L. Youssefian, T. Baghdadi, S. Sotoudeh, A. Tavassoli, S. Zeinali, S. Afsharaalam, J. Uitto
Journal: British Journal of Dermatology (2016)
‘Liver Tail’ Pseudospleen Appearance in Denatured Erythrocyte Scintigraphy with Computed Tomographic and Magnetic Resonance Correlations
Authors: Khatijah Abu Bakar, David MacFARLANE, William Fong, Louise McEWAN
Journal: Clinical Nuclear Medicine (2000)

A patient had thrombocytopenia 15 years after splenectomy for idiopathic thrombocytopenia. A liver–spleen scan was requested to identify possible splenic regrowth. Heat-denatured erythrocyte scintigraphy showed normal hepatic activity, with increased radiotracer activity in the splenic bed, possibly representing significant splenic regrowth. However, both computed tomographic and magnetic resonance images of the abdomen confirmed that the scintigraphic findings represented contiguous tissues arising from the left lobe of the liver, giving a “liver-tail” appearance with all imaging methods. There was no evidence of splenosis elsewhere. Pseudospleen appearance on labeled erythrocyte studies is a potential problem in patients after splenectomy.
FDG Positron Emission Tomographic Imaging of a Large Abdominal Aortic Aneurysm
Authors: Mark D Wilkinson, Edwin Szeto, Michael  J Fulham, Chris J Constable, Brian C McCaughan
Journal: Clinical Nuclear Medicine (2003)

WILKINSON, MARK D. M.B.CH.B.; SZETO, EDWIN F.R.A.C.P.; FULHAM, MICHAEL J. F.R.A.C.P.; CONSTABLE, CHRIS J. B.APP.SC.; MCCAUGHAN, BRIAN C. F.R.A.C.S. Author Information
AB0152 The rs11792633-t allele of il-33 gene is associated with systemic sclerosis
Authors: S. S. Koca, Y. Pehlivan, M. Kara, F. A. Oner, N. Yilmaz, G. Y. Cetin, B. Kisacik, M. Ozgen, O. N. Pamuk, H. Direskeneli, M. Sayarlioglu, A. M. Onat
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by widespread fibrosis of the skin and several visceral organs. Its pathogenesis is not fully known. However, T lymphocytes actives fibroblasts directly via CD154/CD40 ligand or indirectly via pro-fibrotic cytokines including interleukin (IL)-4, IL-6 and transforming growth factor (TGF)-β. Therefore, extracellular matrix components such as collagen and fibronectin are produced by active fibroblasts. The pro-fibrotic potential of IL-33 has been demonstrated by in both <i>in vitro</i> and <i>in vivo</i> settings; moreover, increased level of IL-33 has also been reported in patients with SSc. <h3>Objectives</h3> The aim of the present study was to detect the potential association of IL-33 gene polymorphisms on the susceptibility of SSc. <h3>Methods</h3> 300 SSc patients and 280 healthy controls (HC) from 6 different regions of Turkey were enrolled in this multicentric preliminary candidate gene study. DNA samples were harvested using an appropriate commercial DNA isolation kit. Four single nucleotide polymorphisms (SNPs) of IL-33 gene (rs7044343, rs1157505, rs11792633 and rs1929992) were genotyped using the appropriate commercial primer/probe sets on <i>real-time</i>PCR. Statistical analysis was performed by <i>Chi-square</i> test, and <i>odds</i> ratio (OR) and 95% confidence interval (CI) were determined for alleles. The Tukey-Kramer's method for multiple testing was used and P values less than 0.0125 were considered as significant. <h3>Results</h3> There was no significant difference in terms of the genotypic distributions of evaluated four IL-33 polymorphisms between the SSc and HC groups (p&gt;0.05 for all). Moreover, allelic distributions and MAF of rs7044343, rs1157505, and rs1929992 polymorphism were not significantly different (p&gt;0.05 for all). However, the frequency of rs11792633-T allele was significantly higher in the SSc group compared to the HC group (0.0001, OR: 1.5, % 95 CI: 1.2-1.8). <h3>Conclusions</h3> This preliminary candidate gene study demonstrates thatrs11792633-T allele of IL-33 gene is associated with the susceptibility to the SSc in Turkish population. It may be suggested that IL-33 gene may be a candidate gene to research in SSc. <h3>References</h3> Schmitz J, et al. Immunity. 2005;23:479-90. Rankin AL, et al. J Immunol. 2010;184(3):1526-35. Manetti M, et al. Ann Rheum Dis. 2011;70(10):1876-8. Yanaba K, et al. Clin Rheumatol. 2011;30(6):825-30. Terras S, et al. Ann Rheum Dis. 2013;72(1):144-5. <h3>Acknowledgements</h3> none <h3>Disclosure of Interest</h3> None Declared
Endoscopic sleeve gastroplasty for the treatment of obesity
Authors: Gontrand Lopez-Nava, Manoel Galvão, Immacula da Bautista-Castaño, Amaya Jimenez, Teresa De Grado, Juan Fernandez-Corbelle
Journal: Endoscopy (2014)

<b>Background and study aims:</b> Emerging endoscopic techniques are minimally invasive and can mimic the anatomic alterations achieved by surgical sleeve gastrectomy. The objective of this study was to evaluate endoscopic sleeve gastroplasty. <b>Patients and methods:</b> This was a prospective, single-center study of 20 patients who underwent flexible endoscopic suturing for endoluminal gastric volume reduction. A multidisciplinary team provided postprocedure care. Patient status and weight were recorded at baseline, and at 1, 3, and 6 months after the procedure. <b>Results:</b> There were no adverse events and all patients were discharged in less than 24 hours. Baseline mean body mass index was 38.5 kg/m<sup>2</sup>, and mean age was 45.8 years. Initial body weight (108.5 ± 14.9 kg) was significantly reduced. Following the procedure, the mean body weight reduction was 8.2 ± 2.5 kg at 1 month (% of initial weight loss 7.6 %; <i>P</i> < 0.05), 13.6 ± 4.8 kg at 3 months (12.4 % weight loss; <i>P</i> < 0.05), and 19.3 ± 8.9 kg at 6 months (17.8 % weight loss; <i>P</i> < 0.05). <b>Conclusion:</b> Endoscopic sleeve gastroplasty can be effective for the treatment of patients with obesity.
Tl-201 Chloride SPECT Imaging of Hepatocellular Carcinoma
Authors: JEFFREY S. KEMPF, ROBERT HUDAK, HUSSEIN M. ABDEL-DAYEM, HAL FREIMAN, YVONNE CHEUNG
Journal: Clinical Nuclear Medicine (1996)

Tl-201 chloride has been used to image viable tumors in various sites of the body. There has been limited use of Tl-201 below the diaphragm because of normal uptake in the liver, spleen, kidneys, and intestines. The use of sequential Tl-201 and Tc-99m sulfur colloid in the detection and characterization of suspected hepatocellular carcinoma (HCC) was prospectively evaluated.Four patients with indeterminate liver nodules on radiologic imaging studies were studied with sequential Tl-201 and sulfur colloid liver scans on a triple-headed gamma camera with planar and SPECT acquisition. All patients had subsequent pathologic correlation.There were three focal nodular HCC lesions and one case of multicentric HCC, size varying between 1.9 cm and greater than 4.0 cm (multicentric HCC). In all lesions, Tl-201 SPECT images showed abnormal increased uptake at sites of HCC, which corresponded to areas of photopenia on sulfur colloid. Computed tomography detected a lesion in two of four patients, whereas US was positive in all patients. However, US was specific for tumor in only one patient and CT was not specific in any patient.We believe that in patients with suspected HCC, Tl-201 SPECT imaging will have an important role in the detection and characterization of HCC, especially in the cirrhotic patient. Planar Tl-201 hepatic images will usually be normal, except in large lesions, and high-resolution SPECT technique is essential in successful liver tumor imaging.
Abstract 5327: In vivo fluorescence imaging of solid tumor-bisphosphonate interaction
Authors: Rao V. Papineni, Thirupandiyur Udayakumar, Mansoor Ahmed, John Pizzonia, Alan Pollack
Journal: Cancer Research (2011)

Abstract Bisphosphonates are used for the osteoporosis and in palliative cancer related bone pain management. A role in the cancer cell proliferation and metastases prevention has been proposed. Here, we determined the possibility of utilizing NIR dye conjugated bisphosphonate drug as a potential theragnostic agent. Alendronate was conjugated to water soluble, near-infrared tricarbocyanine, cyclic enamine-functionalized dye, and the imaging probe was used for the purpose. Near-infrared (NIR) fluorescence imaging of both LNCaP cells in cell culture and grown orthotopically in nude mice indicate NIR-bisphosphonate binding. Both in vivo and ex vivo NIRF image analysis of 4 nmol of NIR conjugate delivery show substantial tumor residence time and routine biodistribution to areas of high metabolic bone activity. We present here early evidence of NIR-bisphosphonate analog as a potential diagnostic tool. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5327. doi:10.1158/1538-7445.AM2011-5327