tbuckley/cabot-search huggingface dataset:
Frequent Detection of Human Herpesvirus 6 in Oral Carcinoma
Authors: M. Yadav, A. Chandrashekran, D. M. Vasudevan, D. V. Ablashi
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Frequent Detection of Human Herpesvirus 6 in Oral Carcinoma Get access M. Yadav, M. Yadav Department of Genetics and Cellular Biology, University of MalayaKuala Lumpur, Malaysia Correspondence to: Professor M. Yadav, Ph.D., Department of Genetics and Cellular Biology, University of Malaya, 59100 Kuala Lumpur, Malaysia. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Chandrashekran, A. Chandrashekran Department of Genetics and Cellular Biology, University of MalayaKuala Lumpur, Malaysia Search for other works by this author on: Oxford Academic PubMed Google Scholar D. M. Vasudevan, D. M. Vasudevan Department of Biochemistry, Government Medical CollegeTrichur, Kerala, India Search for other works by this author on: Oxford Academic PubMed Google Scholar D. V. Ablashi D. V. Ablashi Department of Microbiology and Immunology, Georgetown University School of MedicineWashington, D.C.Advanced Biotechnologies Inc.Columbia, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 23, 7 December 1994, Pages 1792–1794, https://doi.org/10.1093/jnci/86.23.1792 Published: 07 December 1994 Article history Received: 08 April 1994 Revision received: 22 July 1994 Accepted: 15 September 1994 Published: 07 December 1994
P16 TB Infection in the UK indigenous white elderly population: a retrospective study of interferon gamma release assays (IGRAs)
Authors: M. Gautam, J. Darroch, P. Davies
Journal: Thorax (2011)

<h3>Introduction</h3> Recent data from The Health Protection Agency (HPA) UK indicates a further rise in the incidence of TB and about 15% cases of newly diagnosed cases of TB occur in those aged =65. Within the indigenous white population in the UK, it is the elderly population in whom TB is principally an issue. In contrast to previous studies looking at TST positivity, the application of IGRAs to detect infected cases of TB across various ethnic groups has not yet been reported. In addition to further quantify TB infection in the UK white population, this study also looked at IGRA positivity in the elderly population. <h3>Methodology</h3> Retrospective study of IGRAs which were performed in cases where latent or active TB was suspected. Data were collected from regional IGRA database and individual hospital audit departments were approached to obtain ethnicity data. <h3>Results</h3> Ethnicity data was available in 575/1119 cases and comprised 482 white British, 26 Asian/Asian British, 34 black/black British and 33 other. IGRAs results in the UK population are shown in the Abstract P16 table 1 below: The difference in the prevalence of a positive IGRA between the ethnic groups was statistically significant (p&lt;0.001). Further age specific analysis was performed for the white British population for whom age data was available. Of these 468/482 cases, 47% were male (222/468) and the mean age was 50 years. The study demonstrated a significant association between age upon the occurrence of a positive IGRA result (p&lt;0.001). The likelihood of a positive IGRA result was found to increase for older subjects. In the Mersey region, for the UK white population aged =65, the prevalence of a positive IGRA result was between 18% and 37% (95% CI). <h3>Conclusions</h3> IGRA positivity was found to be lowest in the white British population compared with other ethnic groups. Interestingly, of the UK indigenous white elderly population almost 1/3 are infected with TB (latent or active) highlighting significant disease burden among older age groups. With IGRAs heralded as the more specific and reliable diagnostic test, such results may aid future planning and policy making for the management of TB in the UK.
AB1122 Coronary artery abnormalities in children with systemic-onset juvenile idiopathic arthritis
Authors: C. Galeotti, I. Koné-Paut
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic-onset juvenile idiopathic arthritis (SoJIA) is characterized by hectic daily fevers, arthritis and evanescent rashes. Diagnosis of SoJIA is often challenging. Infectious diseases and other inflammatory conditions, including Kawasaki disease (KD) may mimic SoJIA. By some way SoJIA and KD share common pattern of autoinflammatory diseases such as fever, rash, and marked elevation of acute phase reactants. Clinicians often rely on echocardiographic evidence of coronary artery dilation to differentiate KD and SoJIA, especially when KD feature is uncomplete. Coronary artery dilation would typically favor the diagnosis of KD. However, in a prospective study in 2004, 5 patients among 12 with SoJIA had coronary artery dilation <sup>1</sup>. <h3>Objectives</h3> We present three other children with SoJIA, and coronary artery abnormalities at the beginning of their disease. <h3>Methods</h3> Patients had an echocardiography before the diagnosis of SoJIA, and while we suspected KD. <h3>Results</h3> The diagnosis of SoJIA was made at the age of 10 months for two patients and 15 months for one patient. KD was suspected initially because they were toddlers with prolonged fever, cutaneous rash and marked biological inflammation. The initial echocardiography of the first patient showed pericarditis and irregular wall of the left coronary artery, without dilation. The second patient had left coronary artery dilation and pericarditis. The third patient had thickening of the left coronary artery wall, without dilatation or pericarditis. They both received IVIg without success. SoJIA was recognized because they did not respond to two infusions of IVIg and because they subsequently developed arthritis. The three patients evolved toward severe corticodependant SoJIA responsive to tocilizumab only in two of them due to refractory polyarthritis. <h3>Conclusions</h3> In very young patients, KD and SoJIA may be confused at the beginning not only by similar observable clinical symptoms but also by the eventuality of subclinical and transient coronary arteries vasculitis. The association of coronary abnormalities to higher severity of SoJIA needs to be confirmed. <h3>References</h3> Binstadt BA, Levine JC, Nigrovic PA, et al. Coronary artery dilation among patients presenting with systemic-onset juvenile idiopathic arthritis. Pediatrics 2005; 116:e89-93. <h3>Disclosure of Interest</h3> None Declared
A Prospective, Matched Comparison Study of SUV Measurements From Time-of-Flight Versus Non–Time-of-Flight PET/CT Scanners
Authors: Holly M. Thompson, Ryogo Minamimoto, Mehran Jamali, Amir Barkhodari, Rie von Eyben, Andrei Iagaru
Journal: Clinical Nuclear Medicine (2016)

As quantitative F-FDG PET numbers and pooling of results from different PET/CT scanners become more influential in the management of patients, it becomes imperative that we fully interrogate differences between scanners to fully understand the degree of scanner bias on the statistical power of studies.Participants with body mass index (BMI) greater than 25, scheduled on a time-of-flight (TOF)-capable PET/CT scanner, had a consecutive scan on a non-TOF-capable PET/CT scanner and vice versa. SUVmean in various tissues and SUVmax of malignant lesions were measured from both scans, matched to each subject. Data were analyzed using a mixed-effects model, and statistical significance was determined using equivalence testing, with P < 0.05 being significant.Equivalence was established in all baseline organs, except the cerebellum, matched per patient between scanner types. Mixed-effects method analysis of lesions, repeated between scan types and matched per patient, demonstrated good concordance between scanner types.Patients could be scanned on either a TOF or non-TOF-capable PET/CT scanner without clinical compromise to quantitative SUV measurements.
AB0510 The relationship between nailfold capillaroscopic assessment and telangiectasia score with severity of peripheral vascular involvement in systemic sclerosis
Authors: Y. Yalcinkaya, O. Pehlivan, N. Alpay, A. Omma, B. Erer, S. Kamali, L. Ocal, M. Inanc
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To determine the association of nailfold videocapillaroscopy(NVC)findings and telangiectasia score with DU history and severity of peripheral vascular involvement(PVI) in Systemic Sclerosis(SSc). <h3>Methods</h3> Fifty-nine SSc patients fulfilling Leroy and Medsger criteria were evaluated including Telangiectasia Score(TS)(Shah AA et al. J Rheumatol 2010), Modifiye Rodnan Skin Score(MRSS), Valentine Activity Scale(VAS) and Medsger Severity Scale(SS). Qualitative(early, active and late patterns) and semiquantitative assessments [capillary number(CN), irregularly enlarged capillaries(IEC), giant capillaries(GC), capillary ramifications(CR), microhaemorrhages(H), capillary array disorganisation(CAD) and microangiopathy evolution score(MES)]. was performed by NVC(Sulli et al. Ann Rheum Dis 2008) <h3>Results</h3> The mean age of patients was 45.6 and 91,5% were females. The mean duration of Raynaud's(RS), non-Raynaud symptoms(NRS), skin involvement(SI)(year) were 6.1±6.5, 3.1±2.0, 3.0±2.0 respectively. Of the patients 20(34%) were diffuse cutaneous,35(59%) were limited and 4(7%) were sine-scleroderma;13(22%) were anti-centromere(+) and 29(49%) were anti-Scl70(+). DU history (DU+) was present in 27(46%) and telangiectases were present in 34(58%). When we compare DU- and DU + groups, the mean score of CN was 1.4±0.7 vs 2.0±0.5*(p&lt;0.001), IEC was 1.4±0.7 vs 1.8±0.6**(p&lt;0.05), MES was 1.8±1.0 vs 2.5±1.5**(p&lt;0.05); early pattern was in 9 vs 1, active pattern was in 16 vs 14, late pattern was in 7 vs 12 patients. Current PVI grouped as Not Severe(SS;0-1)(n=43) or Severe(SS;2-4)(n=16). The frequency of severe PVI was 22% in females(12/54) and 80% in males(4/5). The mean values of TS, MRSS, VAS, SS were similar between groups. When we compare Not Severe and Severe groups, the mean score of CN was 1.5±0.7 vs 2.1±0.4*(p&lt;0.001), MES was 1.8±1.1 vs 2.8±1.6** (p&lt;0.05); early pattern was in 10 vs 0, active pattern was in 21 vs 9, late pattern was in 12 vs 7 patients. <h3>Conclusions</h3> DU history and severe PVI in SSc was associated with capillary loss and microangiopathy. 'Early' NVC pattern was very rare in patients with DU history and was not found in severe PVI. Severe PVI in males was more frequent than females. Telangiectasia scores were not found to be related to PVI. NVC may be a helpful method in the assessment of SSc patients for PVI prognosis, warranting prospective studies. <h3>Disclosure of Interest</h3> None Declared
PTU-011 Identifying The Learning Needs Of Bsw Colonoscopists Using An Active Learning Diary During Screening Lists
Authors: N Hawkes, J McDonald
Journal: Gut (2014)

<h3>Introduction</h3> In the Bowel Screening Wales (BSW) programme screeni, UKng colonoscopists must meet specified performance criteria and pass both a knowledge-based and practical skills assessment. As such they are highly skilled endoscopists who engage in self-directed learning. We aimed to determine the nature and frequency of ongoing learning opportunities arising on BSW screening lists and practicality of using a structured learning diary. <h3>Methods</h3> A stratified randomisation identified six BSW colonoscopists (one from each Health Board). A structured diary recording 'active' learning opportunities and self-reflection on learning events (after Knowles) was combined with semi-structured interviews after data collection (minimum 4 BSW lists). A deductive approach to data analysis using a modified grounded theory approach described by Burnard <i>et al</i>. (2008) was used. <h3>Results</h3> BSW colonoscopists identified lesion assessment and decision-making (cognitive skills) as the most common learning points. Technical challenges (skills based) and aspects of team performance (attitudinal) were also common. Problems requiring 'situational awareness' or where things were not going to plan (including equipment failure) were less common but prompted more active reflection by colonoscopists. Cumulative entries recorded 35 distinct learning points (some duplicated by more than one colonoscopist) in the following domains; polyp detection and assessment; optimising field of view and access; polyp pre-treatment or lifting; snare selection/technique; diathermy modes and settings; complications; situational awareness and teamwork; judgement and decision-making. All participants felt the data recorded was representative of their normal screening lists (making the learning points transferable to other colonoscopists) and felt that using the diary was feasible and helpful. Participants did not always translate recorded reflections into discernable action plans with specific learning goals mainly due to time constraints – where behaviour changed this was facilitated by local opportunities to discuss with near-peers or during formal endoscopy-based multi-disciplinary meetings. A variety of learning resources were used. <h3>Conclusion</h3> The structured learning diary proved to be a practical and useful tool to identify learning opportunities in the context of routine BSW screening lists. Participants identified a number of learning needs – most commonly reported were cognitive skills related to lesion assessment and decision-making. Active reflection promoted by using this kind of tool is most effective when leading to the setting of specific goals and linked to supportive local collaborative working patterns. <h3>Reference</h3> Burnard P, Gill P, Stewart K, <i>et al</i>. Analysing and presenting qualitative data. <i>Br Dental J</i> 2008;204:429–432. <h3>Disclosure of Interest</h3> None Declared.
Factor V Leiden mutation in patients with breast cancer and a central venous catheter: Relationship with deep vein thrombosis
Authors: G. Curigliano, M. Mandalà, P. Bucciarelli, G. Peruzzotti, M. Colleoni, R. Biffi, P. Mannucci, F. De Braud, P. Pelicci, A. Goldhirsch
Journal: Journal of Clinical Oncology (2004)

8020 Background: Disorders of coagulation are encountered in up to 90% of cancer patients (pts), although only 15% of them develop a localized acute or chronic deep venous thrombosis (DVT) or a disseminated intravascular coagulation. Aim of the study was to assess the influence of the prothrombotic factor V Leiden and G20210A prothrombin mutation on the prevalence of the 1st event of catheter-related deep vein thrombosis in a cohort of pts with locally advanced or metastatic breast cancer during continuous venous insult (infusion of fluorouracil-based chemotherapy). Methods: Between 1.1999 and 2.2001, we retrospectively analyzed the incidence of first deep vein thrombosis in 300 consecutive pts with locally advanced or metastatic breast cancer treated in a single institution with a combination of chemotherapy administered continuously through a totally implanted access port. We identified 25 women (study group; cases) with catheter-related deep vein thrombosis. For each we selected two pts (50 pts - controls) for identical chemotherapy, similar age, stage of disease and prognostic features. The prothrombotic factor V Leiden and prothrombin mutation G20210A genotype analyses were performed in all patients who signed a specific informed consent. All samples were blinded. Results: All 25 cases and 50 frequency-matched controls were evaluated for Factor V Leiden. Five cases and 2 controls were found with the mutation in the factor V Leiden for a frequency of 20% (95% CI= 9%–39%) and 4% (95% CI=1%-14%) respectively. Thus, the frequency of the mutation was significantly higher in the cases than in controls (p=0.04) and a logistic regression analysis, adjusted by age, yielded an odds ratio of 6.1 (95% CI=1.1–34.3; p=0.04). Only one patient (case) was found with the G20210A mutation in the prothrombin gene. Conclusions: Factor V Leiden carriers with locally advanced or metastatic breast cancer are at high risk of catheter-related deep vein thrombosis during chemotherapy. Clinicians should be aware of this increased risk and antithrombotic phophylaxis should be considered for these patients. No significant financial relationships to disclose.
Abstract P1-13-09: A multicenter randomized study comparing the dose dense G-CSF-supported sequential administration of FEC followed by docetaxel versus paclitaxel as adjuvant chemotherapy in women with axillary lymph node positive breast cancer.
Authors: D Mavroudis, N Malamos, I Boukovinas, S Kakolyris, C Kourousis, A Athanasiadis, N Ziras, P Makrantonakis, A Polyzos, C Christophylakis, V Georgoulias
Journal: Cancer Research (2012)

Abstract Purpose: To compare the efficacy of dose dense docetaxel versus paclitaxel following FEC as adjuvant chemotherapy in node positive early breast cancer. Patients and treatment: Women 18–75 years old with histologically confirmed HER2-negative invasive breast carcinoma surgically resected with at least one infiltrated axillary lymph node and absence of metastatic disease were randomized to receive 4 cycles of fluorouracil (700mg/m2), epirubicin (75mg/m2), cyclophosphamide (700mg/m2) followed by 4 cycles of either docetaxel (75mg/m2) or paclitaxel (175mg/m2). All chemotherapy cycles were administered every 14 days with G-CSF support. Stratification was based on menopausal status, number of involved nodes and hormone receptor expression. The primary endpoint of the study was to compare the disease-free survival (DFS) at 3 years and 239 patients were scheduled to enroll on each arm. Results: Between 2004–2007, 481 women were randomized and received FEC followed by docetaxel (arm A; n=240) or paclitaxel (arm B; n=241). The median age was 55 years in both arms, premenopausal status 31.3% versus 32.8%, more than 10 involved axillary nodes in 12.9% versus 12.4%, histological grade 3 tumor in 36.3% versus 35.3% and hormone receptor negative disease in 14.6% versus 12% of patients in arms A and B, respectively. After a median follow up of 56.3 and 55.6 months (p = 0.3) for arms A and B, respectively, there were 42 (17.5%) versus 47 (19.5%) disease relapses (p = 0.5) and 20 (8.3%) versus 22 (9.1%) disease-related deaths (p = 0.7), respectively. The 3-year DFS rates were 88.1% versus 87.3% for arms A and B, respectively. Toxicity included grade 2–4 neutropenia in 31% versus 21% (p = 0.01), thrombocytopenia 3.5% versus 0.8% (p = 0.06), febrile neutropenia 2.1% versus 1.2% (p = 0.5), diarrhea 3.7% versus 2.5% (p = 0.4), neurotoxicity 2.9% versus 4.6% (p = 0.3) of patients in arms A and B, respectively. There were no toxic deaths. Conclusion: The dose dense administration with G-CSF support of FEC followed by either docetaxel or paclitaxel as adjuvant chemotherapy in women with node positive early breast cancer is well tolerated and results in a similar 3-year DFS rate. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-13-09.
Targeted Drug Development in Pediatric Cancer Despite a Low Frequency of Tumor Driving Mutations
Authors: J.J. Molenaar, J. Koster, M. Ebus, D.A. Zwijnenburg, P. van Sluis, F. Lamers, L. Schild, I. van der Ploeg, H.N. Caron, R. Versteeg
Journal: Annals of Oncology (2013)
Film: Patch Adams
Authors: C Essex
Journal: BMJ (1999)

was the quintessential "action painter."A muscular man stooping over canvasses he'd laid on the ground, he dripped and flung paint in the white T shirt and faded jeans immortalised in iconic portraits.He had appropriated this "uniform" long before Bruce Springsteen wore it.Indeed, his very "Americaness" prompted claims that he was not a great painter at all but a stooge for the New York art scene elite, set up to rival the European tradition, in particular Picasso.Certainly, it is difficult to overlook the resemblance to the work of the Spaniard in many of Pollock's early and middle paintings.Pollock breaks free only when he puts aside representation altogether and enters the abstract realm (violently).It begins with the Mural he painted for the heiress Peggy Guggenheim one apocryphal New Year's night .In fact, the painting could not have been completed in one "campaign" or the colours would have bled into each other on the canvass; the life of Pollock lends itself to legend from beginning to end.He was born in Cody, Wyoming, in 1912, the youngest of five brothers.His father made a series of business errors and spent periods working away from home, living the itinerant life in working gangs, where violence and alcoholism were common.Jackson was the third brother to become an artist, but he lacked the technical facility of his siblings.His early style is brutish and ordinary, and his young adulthood is more notable for his drinking, fighting, and failing with women.He was at pains to prove his masculinity.He believed that he would be an artist, a belief as much to do with acquiring an identity as expressing a point of view.He progressed through a series of attachments to father figures-some of them artists who encouraged him and others critics who saw in him something they could mould.Periods of relative tranquillity and creativity accompanied Pollock's time in Jungian analysis and the early years of his marriage to Lee Krasner.But when his forging ahead into newer forms of abstraction began to falter he resorted to drink, and his demons returned.Seeing all of Pollock's oeuvre in one exhibition is a profoundly moving experience.The colours, the brio, cry out to be seen.The complexity of synapses floods these rooms; an abstract language seared with emotion.And then there is the last phase as he scrambles for new forms, his powers failing; the "black" series presages a coming storm.Jackson Pollock died in a car crash on an empty road.He was 44.He had been drinking all day.
658 microRNA PROFILE IN CHRONIC HEPATITIS B RELATED HEPATOCELLULAR CARCINOMA: OVEREXPRESSION OF microRNA-224 IN HEPATOCELLULAR CARCINOMA TISSUE CAN PREDICT RECURRENCE AFTER CURATIVE RESECTION
Authors: S.J. Lee, J.E. Yeon, H.R. Kim, K.H. Kang, S.H. Kang, H.J. Lee, E.L. Yoon, S.J. Suh, J.H. Kim, Y.S. Seo, H.J. Yim, K.S. Byun
Journal: Journal of Hepatology (2013)
SYSTEMIC INFLAMMATION IS ASSOCIATED WITH CORONARY ARTERY CALCIFICATION AND ALL-CAUSE MORTALITY IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Authors: In-Chang Hwang, Hyo Eun Park, Hack-Lyoung Kim, Hyue Mee Kim, Jun-Bean Park, Yeonyee Yoon, Seung-Pyo Lee, Hyung-Kwan Kim, Goo Yeong Cho, Dae Won Sohn, Yong-Jin Kim
Journal: Journal of the American College of Cardiology (2016)