tbuckley/cabot-search huggingface dataset:
THU0129 Urogenital AA Amyloidosis in Rheumatoid Arthritis – A Postmortem Clinicopathologic Study of 234 Autopsy Patients
Authors: Ά. Apáthy, M. Bély
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> AA amyloidosis (AAa) is one of the main complications of rheumatoid arthritis (RA). All visceral organs may be involved to various degrees. <h3>Objectives</h3> The aim of this study was to determine the <i>prevalence</i>, and <i>severity</i> of amyloid A deposits in male urogenital organs of RA patients. <h3>Methods</h3> A randomized autopsy population of 234 in-patients with RA was studied. AAa complicated RA in 48 (20.5%) of 234 cases (females 38, and males 10). RA was diagnosed clinically according to the criteria of the American College of Rheumatology (ACR). The existence of amyloid A deposits in male urogenital organs were determined histologically. The “severity” (extent) of amyloid A deposits was evaluated by semi-quantitative, visual estimation on a 0 to 3 plus scale, based on the number of involved blood vessels per light microscopic field (x40 objective of an Olympus BX51). <h3>Results</h3> The prevalence and the average amount of amyloid A deposits in male urogenital organs are summarized in Table 1, and demonstrated in Figure 1 <h3>Conclusions</h3> Amyloid A precursors are produced by the liver and via the blood stream deposit in various organs according to the blood perfusion (1). The rate and amount of amyloid deposition in organs is basically determined by their volume and by the volume of blood per minute reaching those (2). The deposition of amyloid A is more pronounced in kidneys, testis or prostate than in the epididymis or penis. Kidney, prostate or testes (because the high prevalence and massivity of amyloid A deposits) – like the gastrointestinal tract – could be a good target for biopsy to diagnose amyloidosis. Biopsy of prostate is less stressful than biopsy of kidneys. The risk of AAa is high in RA, therefore all tissue samples – regardless of the reason for removal – is suggested to be screened for amyloiosis in any case. The diagnosis of amyloidosis depends on the specificity and sensitivity of the applied method. Using a less sensitive staining method some positive cases – with minimal amyloid deposits – remain undetected. The more specific and sensitive Congo red staining according to Romhányi is suggested for detection of amyloid deposits in comparison with Puchtler9s Congo red methods (3). <h3>References</h3> Bély M, Apáthy Ά. Histochemical and immunohistichemical differential diagnosis of amyloidosis - a brief illustrated essay and personal experience with Romhányi9s method. Amyloid, 2000; 7:212-217. Bély M, Apáthy Ά, Pintér T, Ratkό I. Generalized secondary amyloidosis in rheumatoid arthritis. Acta Morph. Acad Sci Hung 1992;40:49-69. Bély M, Makovitzky J. Sensitivity and Specificity of Congo red Staining According to Romhányi - Comparison with Puchtler9s or Bennhold9s Methods. Acta Histochemica, 2006; 108:175-180 <h3>Disclosure of Interest</h3> None declared
SP0222 Top Tips for a Successful Pregnancy for Couples Affected by an RMD
Authors: M. Ostensen
Journal: Annals of the Rheumatic Diseases (2015)

New effective therapies have made it possible for many patients with rheumatic disease (RD) to consider having children. Living with a chronic disease means a lot of uncertainty in regard to the future, so the patient needs to plan many things much more carefully than healthy people. Having a family is one of the options in life that should be planned in case of RD. Given the fact that RDs often have an undulating disease course with good and bad days, and that medication use to control disease activity is necessary over prolonged periods of time, family planning is crucial. Studies have shown that pregnancies that occur during very active disease carry the risk of a worsening of disease in the mother and of unfavourable outcomes for the child. Therefore conception should take place during a period of remission or low disease activity. Therapy with drugs should be stable and consist of medications that are compatible with pregnancy. A clinical assessment by the rheumatologist will reveal particular risks for a future pregnancy, and which measures can be taken to reduce them. Taking drugs during pregnancy is often a great concern for the mother, therefore a discussion with the rheumatologist already before a planned pregnancy is important. Only few dugs administered for RD can harm the child, and these must be discontinued before pregnancy. However, a patient should not stop any medication without having consulted with her physician. A flare of disease may occur after the sudden stop of a medication. Some drugs protect against a worsening of disease and should therefore be continued during pregnancy. Management of pregnancy in a patient with RD requires collaboration of several specialists including the rheumatologist, obstetrician, and sometimes a paediatrician as well. The patient should ensure that the health professionals involved in her care know of each other and take contact with each other. In case collaboration is neglected the patient may get confused by contradictory advice, experience repetition of laboratory tests that already have been taken by one specialist or suffer a delay of treatment because none of the specialists knows for sure which responsibility he or she should have. To establish good interaction between the doctors, nurses, midwives and others is really important for the pregnant patient. The key messages for a successful pregnancy are: –Plan pregnancy –Take a pre-pregnancy counselling with the doctors involved in your care –Don9t stop all medication before pregnancy –Facilitate good collaboration between the specialists who manage your pregnancy <h3>References</h3> Østensen M. Contraception and pregnancy counseling in rheumatoid arthritis. Curr Op Rheumatol 2014; 26(3): 302-7. <h3>Disclosure of Interest</h3> None declared
Association analysis of the catechol O-methyltransferase gene and bipolar affective disorder
Authors: B Gutiérrez, J Bertranpetit, R Guillamat, V Vallès, M J Arranz, R Kerwin, L Fañanás
Journal: American Journal of Psychiatry (1997)

Catechol O-methyltransferase (COMT) is an enzyme that inactivates catecholamines. Two common COMT alleles determine high and low activity of the enzyme. Previous studies using biochemical methods found lower enzyme activity in patients with major depression and bipolar disorder in comparison with control values, suggesting that a dysfunction in catecholamine metabolism may be related to the etiology of depression.The authors studied two recently described DNA polymorphisms at the COMT gene (a silent C256G mutation and a structural mutation, Val-108-Met) in 88 patients with bipolar disorder and in 113 healthy comparison subjects, all of Spanish origin.The frequency of the C256 allele was 0.58 in the patients and 0.54 in the comparison subjects. The frequency of the Val108 variant was 0.57 for both the patients and the comparison subjects. No allelic or genotypic associations were observed.The lack of association suggests that the COMT gene is not a major risk factor for bipolar disorder.
Effect of hospital admission on DST results
Authors: E F Coccaro, J Prudic, A Rothpearl, H G Nurnberg
Journal: American Journal of Psychiatry (1984)

The authors examined the dexamethasone suppression test (DST) responses of 41 patients with primary major depressive disorder and 40 patients with other psychiatric disorders who were tested within 2-6 days of hospital admission. Significantly more patients with primary depression who were tested on day 2 demonstrated abnormal cortisol suppression than those who were tested on days 3, 4, or 3-6 and than patients with other psychiatric disorders regardless of test day. These results suggest that patients with primary depression may be sensitive to psychophysiologic stresses associated with hospital admission and that the utility of the DST may require further evaluation vis-à-vis the day of DST administration.
Spontaneous Regression of Pulmonary Metastases and Long-Term Survival of a Patient with Metastatic Renal Cell Carcinoma, after Immunostimulation with Bacillus Calmette-Guérin and Extirpation of Brain and Contralateral Lung Metastases
Authors: L Martínez-Piñeiro, J de la Peña, M L Picazo, J Jiménez León, M Beneitez, J A Martínez-Piñeiro
Journal: European Urology (1988)
The impact of antipsychotic drug regulations on psychotropic prescribing practices in nursing homes
Authors: B W Rovner, B A Edelman, M P Cox, Y Shmuely
Journal: American Journal of Psychiatry (1992)

The authors prospectively studied psychotropic prescribing practices and quality assurance data in 17 nursing homes in the Baltimore area to assess the impact of federal antipsychotic drug regulations. There was a 36% reduction in prescriptions for neuroleptics over 6 months, no increase in prescriptions for sedative/hypnotics, and a small increase in prescriptions for antidepressants. The authors conclude that psychotropic drug prescribing practices and patient outcomes remain important areas of study in nursing homes.
Fiberoptic Bronchoscopy
Authors: William J. Fulkerson
Journal: New England Journal of Medicine (1984)

DIRECT examination of the tracheobronchial tree with flexible fiberoptic bronchoscopy has greatly facilitated the diagnosis, staging, and management of pulmonary neoplasms and other lung diseases.1 New technology and techniques have expanded the indications for bronchoscopy. The purpose of this brief review is to help physicians understand the indications, diagnostic and therapeutic utility, limitations, and potential complications of fiberoptic bronchoscopy.IndicationsThe generally accepted indications for fiberoptic bronchoscopy are listed in Table 1. Physical-examination findings, chest radiographs, or sputum studies that suggest neoplasia should lead to fiberoptic bronchoscopy to determine the tissue type and endobronchial extent of the tumor.Patients with an . . .
Necroptosis: A Novel Cell Death Modality and Its Potential Relevance for Critical Care Medicine
Authors: Gabriel Moreno-Gonzalez, Peter Vandenabeele, Dmitri V. Krysko
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Section:ChooseTop of pageAbstract <<Molecular Mechanisms of N...Necroptosis in the Physio...Sepsis and Systemic Infla...Acute Kidney InjuryOther Illnesses Relevant ...Are Tools Available to St...ConclusionsReferencesCITING ARTICLES
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1979)

COMMITTEE ON MATERNAL WELFAREPulmonary Hypertension and Pre-eclampsiaA five-year-old girl with congenital heart disease was found on cardiac catheterization to have a ventricular septal defect, dilatation of the pulmonary artery, and pulmonary hypertension (Eisenmenger's syndrome). The abnormality was considered inoperable not only initially, but also at subsequent annual reexaminations and after a second catheterization when the patient was 14.Only moderately restricted during childhood, she was married at the age of 15 and practiced contraception until 19, when she sought advice regarding pregnancy. Studied by a cardiologist and an obstetrician, she was informed that a successful pregnancy might be . . .
A New Diagnostic Aid in Traumatic Hemobilia
Authors: M Tanaka, M Uchiyama, T Umezaki, T Gotoh
Journal: Endoscopy (1977)

A case report of traumatic hemobilia following suture of superficial laceration of the liver is presented. The diagnosis was confirmed by emergency endoscopy preoperatively. Segmental hepatic resection was successful. Endoscopy is the most convenient as well as harmless procedure in establishing the diagnosis preoperatively. The importance of careful observation of the papilla of Vater in endoscopy to determine the site of upper gastrointestinal hemorrhage is emphasized. In addition, the introduction of serial endoscopy to follow the course of mild hemobilia is suggested.
Ethical Issues in Environmental Health Research Related to Public Health Emergencies: Reflections on the GuLF STUDY
Authors: David B. Resnik, Aubrey K. Miller, Richard K. Kwok, Lawrence S. Engel, Dale P. Sandler
Journal: Environmental Health Perspectives (2015)

SummaryHealth research in the context of an environmental disaster with implications for public health raises challenging ethical issues. This article explores ethical issues that arose in the Gulf Long-term Follow-up Study (GuLF STUDY) and provides guidance for future research. Ethical issues encountered by GuLF STUDY investigators included a) minimizing risks and promoting benefits to participants, b) obtaining valid informed consent, c) providing financial compensation to participants, d) working with vulnerable participants, e) protecting participant confidentiality, f) addressing conflicts of interest, g) dealing with legal implications of research, and h) obtaining expeditious review from the institutional review board (IRB), community groups, and other committees. To ensure that ethical issues are handled properly, it is important for investigators to work closely with IRBs during the development and implementation of research and to consult with groups representing the community. Researchers should consider developing protocols, consent forms, survey instruments, and other documents prior to the advent of a public health emergency to allow for adequate and timely review by constituents. When an emergency arises, these materials can be quickly modified to take into account unique circumstances and implementation details.
The Protective Effects of Fasting on Irinotecan Induced Side Effects; a Pharmacokinetic Study
Authors: S.A. Huisman, P. De Bruijn, I. Ghobadi Moghaddam-Helmantel, J.N.M. Ijzermans, E.A.C. Wiemer, R.H.J. Mathijssen, R.W.F. De Bruin
Journal: Annals of Oncology (2014)
Randomized trials in rare tumors.
Authors: J F Holland
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.9.1163 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4031966 Randomized trials in rare tumors. J F HollandxJ F HollandSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.9.1163 First Page PDF © 1985 by American Society of Clinical Oncology
Worlds Apart
Authors: Daniel A Waxman
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous Cerebrospinal Fluid Leak With Venous Engorgement Mimicking a Contrast-Enhancing Cervical Mass
Authors: Marina Herwerth, Sascha Prothmann, Kornelia Kreiser, Bernhard Hemmer, Markus Ploner
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Development and External Validation of a Melanoma Risk Prediction Model Based on Self-assessed Risk Factors
Authors: Kylie Vuong, Bruce K. Armstrong, Elisabete Weiderpass, Eiliv Lund, Hans-Olov Adami, Marit B. Veierod, Jennifer H. Barrett, John R. Davies, D. Timothy Bishop, David C. Whiteman, Catherine M. Olsen, John L. Hopper, Graham J. Mann, Anne E. Cust, Kevin McGeechan
Journal: JAMA Dermatology (2016)

<h3>Importance</h3> Identifying individuals at high risk of melanoma can optimize primary and secondary prevention strategies. <h3>Objective</h3> To develop and externally validate a risk prediction model for incident first-primary cutaneous melanoma using self-assessed risk factors. <h3>Design, Setting, and Participants</h3> We used unconditional logistic regression to develop a multivariable risk prediction model. Relative risk estimates from the model were combined with Australian melanoma incidence and competing mortality rates to obtain absolute risk estimates. A risk prediction model was developed using the Australian Melanoma Family Study (629 cases and 535 controls) and externally validated using 4 independent population-based studies: the Western Australia Melanoma Study (511 case-control pairs), Leeds Melanoma Case-Control Study (960 cases and 513 controls), Epigene-QSkin Study (44 544, of which 766 with melanoma), and Swedish Women’s Lifestyle and Health Cohort Study (49 259 women, of which 273 had melanoma). <h3>Main Outcomes and Measures</h3> We validated model performance internally and externally by assessing discrimination using the area under the receiver operating curve (AUC). Additionally, using the Swedish Women’s Lifestyle and Health Cohort Study, we assessed model calibration and clinical usefulness. <h3>Results</h3> The risk prediction model included hair color, nevus density, first-degree family history of melanoma, previous nonmelanoma skin cancer, and lifetime sunbed use. On internal validation, the AUC was 0.70 (95% CI, 0.67-0.73). On external validation, the AUC was 0.66 (95% CI, 0.63-0.69) in the Western Australia Melanoma Study, 0.67 (95% CI, 0.65-0.70) in the Leeds Melanoma Case-Control Study, 0.64 (95% CI, 0.62-0.66) in the Epigene-QSkin Study, and 0.63 (95% CI, 0.60-0.67) in the Swedish Women’s Lifestyle and Health Cohort Study. Model calibration showed close agreement between predicted and observed numbers of incident melanomas across all deciles of predicted risk. In the external validation setting, there was higher net benefit when using the risk prediction model to classify individuals as high risk compared with classifying all individuals as high risk. <h3>Conclusions and Relevance</h3> The melanoma risk prediction model performs well and may be useful in prevention interventions reliant on a risk assessment using self-assessed risk factors.
Acute Lymphoblastic Leukemia Is a Bcl-2 Dependent Disease: Proteomic Profiling and Pre-Clinical Efficacy Of a Selective Bcl-2 Antagonist ABT-199
Authors: Marina Konopleva, Juliana M Benito, Karine G. Harutyunyan, Isabel Marzo, LaKiesha Debose, Oscar Gonzalo, Ping Zhou, Rodrigo Jacamo, Eugene Park, Markus Muschen, James C. Mulloy, Linda J Bendall, Patrick A Zweidler-McKay, Kevin R. Coombes, Yihua Qiu, Nianxiang Zhang, Joel Leverson, Deborah A. Thomas, Susan O'Brien, Hagop M. Kantarjian, Steven M. Kornblau, Michael Andreeff
Journal: Blood (2013)
Responses to hypercarbia induced by acetazolamide in panic disorder patients
Authors: R J Mathew, W H Wilson, S Tant
Journal: American Journal of Psychiatry (1989)

CO2 inhalation has been reported to induce panic attacks in panic disorder patients. State anxiety, somatic symptoms of anxiety, physiological changes, and cerebral blood flow (CBF) were monitored in panic disorder patients before and after intravenous injections of 1 g of acetazolamide (13 patients) and saline (10 patients), given under double-blind conditions. In spite of significant hypercarbia, as evidenced by increased CBF in the former group, only one subject reported panic and even that attack did not meet DSM-III-R criteria. There was only one significant difference between the drug and placebo groups; the acetazolamide group experienced significantly more dizziness.
Adjustment of a Group of Vietnamese People to the United States
Authors: A. Joe Vignes, Richard C.W. Hall
Journal: American Journal of Psychiatry (1979)

The authors collected data on 50 Vietnamese families living in Baton Rouge, Louisiana, by individual and group interview questionnaire. They also used interviews of all of the Vietnamese people who came to the local community mental health center and studied the records of the center and other local social agencies for sociodemographic data. They define a number of specific sociological stresses encountered by Vietnamese refugees but conclude that basically these people are adjusting well without losing their cultural identity.
Genome sequence analysis of Ebola virus in clinical samples from three British healthcare workers, August 2014 to March 2015
Authors: A Bell, K Lewandowski, R Myers, D Wooldridge, E Aarons, A Simpson, R Vipond, M Jacobs, S Gharbia, M Zambon
Journal: Eurosurveillance (2015)

We determined complete viral genome sequences from three British healthcare workers infected with Ebola virus (EBOV) in Sierra Leone, directly from clinical samples. These sequences closely resemble those previously observed in the current Ebola virus disease outbreak in West Africa, with glycoprotein and polymerase genes showing the most sequence variation. Our data indicate that current PCR diagnostic assays remain suitable for detection of EBOV in this epidemic and provide confidence for their continued use in diagnosis.