tbuckley/cabot-search huggingface dataset:
Abstract 1283: A study towards identification of plausible protein markers of squamous cell carcinoma
Authors: Manish Mahajan, Pallavi Manral, Mayank Saraswat, N K. Shukla, A Srinivasan, Savita Yadav
Journal: Cancer Research (2012)

Abstract Oral cancer is a group of carcinoma that accounts for most common cancer related morbidity in India and 6th most common in western world. Use of Clinical proteomics is a novel way of studying differential proteins in diseased and non- diseased states. 2 - Dimensional Gel Electrophoresis followed by mass spectrometry was used to study the differential protein expression in case of squamous cell carcinoma of buccal pouch using human whole saliva as sample. It was found that there was consistent over - expression of three proteins viz., Cytokeratin type I, Cytoskeletal Associated Protein −2 and a hypothetical protein. Elevation of cytokeratin expression is a well-known tool for immunohistological staining for various cancers of epithelial origin. Cytoskeletal Associated Protein −2 is p53 target genes whose functions are still under scrutiny but related to microtubule stabilization during mitosis. This may be implicated in causing aneuploidy in cancer cell, thus, affecting their overall prognosis. This finding in other cases may be used as a method to segregate cases of buccal pouch cancer as poor prognosis and hence, early intervention and better treatment outcome. Over expression of hypothetical protein in our results still needs further experimentation to vindicate our findings. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1283. doi:1538-7445.AM2012-1283
AUTO-FELLATIO
Authors: MORRIS M. KESSLER, GEORGE E. POUCHER
Journal: American Journal of Psychiatry (1946)

1. Reference is made to the first recorded case of self-or auto-fellatio and a second one is presented. 2. The original patient was overtly homosexual; ours had strong latent homosexual tendencies. 3. The relationship of auto-fellatio, narcissism and homosexuality is discussed.
Interstitial Nephritis with Anti-Tubular-Basement-Membrane Antibody
Authors: Jerry Bergstein, Neil Litman
Journal: New England Journal of Medicine (1975)

To determine the pathogenesis of interstitial nephtitis, immunopathological studies were performed with kidney and serum from a six-year-old boy. The kidney revealed linear staining of tubular basement membranes with antiserums specific for human IgG and C3; the membranes also showed fixation of heterologous complement. After incubation of the patient's serum on frozen sections from normal human kidneys, linear staining with IgG was detected by indirect fluorescence. This staining was eliminated by absorption of the serum with purified tubular basement membranes, but was unaltered by absorption with purified glomerular basement membrane. The antibody reacted with mouse, rabbit, dog, sheep, monkey, Sprague-Dawley and Lewis/Brown Norway rat tubular basement membranes, but not with that of Lewis rat or guinea pig, or with human skin, thyroid, parotid, lung, liver or pancreas. Anit-tubular-basement-membrane antibody may be involved in the pathogenesis of the patient's disease.
PROTESIS ESOFÁGICAS TOTALMENTE CUBIERTAS EN EL TRATAMIENTO DE LAS FÍSTULAS ANASTOMOTICAS POSTQUIRURGICAS
Authors: A Repiso, JJ Blanco, JM Carrobles
Journal: Endoscopy (2011)

Objetivos: Evaluar en nuestro medio la utilidad de las prótesis esofágicas totalmente cubiertas en el tratamiento de las fistulas anastomóticas postquirúrgicas.
AT-60 * A RANDOMIZED DOUBLE BLIND PLACEBO-CONTROLLED PHASE 2 TRIAL OF DENDRITIC CELL (DC) VACCINE ICT-107 FOLLOWING STANDARD TREATMENT IN NEWLY DIAGNOSED PATIENTS WITH GBM
Authors: P. Wen, D. Reardon, S. Phuphanich, R. Aiken, J. Landolfi, W. Curry, J.-J. Zhu, M. Glantz, D. Peereboom, J. Markert, R. Larocca, D. O'Rourke, K. Fink, L. Kim, M. Gruber, G. Lesser, E. Pan, S. Kesari, J. Yu
Journal: Neuro-Oncology (2014)

BACKGROUND: This double-blinded randomized phase 2 trial of ICT-107 in newly-diagnosed glioblastoma (GBM) patients rigorously tested efficacy, safety, QoL, and immune response. METHODS: HLA-A1+ and/or -A2+ resected patients with residual tumor <1 cm3 received 6wks of concurrent temozolomide (TMZ) and radiation. 124 patients, randomized 2:1, received ICT-107 (autologous DCs pulsed with 6 synthetic peptide CTL epitopes targeting GBM tumor/stem cell-associated antigens MAGE-1, HER-2, AIM-2, TRP-2, gp100, and IL-13Rα2) or matching control (unpulsed DC). Patients then received induction ICT-107 or control QWx4 followed by maintenance TMZ, 5 days/mo for 12mos. Maintenance vaccinations occurred at 1, 3, and 6mos after induction, and every 6mos thereafter until progression. RESULTS: ICT-107 was generally safe and well tolerated, with no AE imbalance between treated and control. At the 67-event trial completion, median OS had not been reached. Follow-up continues: at 79 events, median OS favored ICT-107 by 1.6mos in the ITT and 1.9mos in the PP (117 patients completing induction) groups, although not statistically significant (p = 0.64 two-sided, HR = 0.89, and p = 0.48, HR = 0.84, respectively). Median PFS was significantly improved in the ICT-107 ITT and PP groups by 2.2mos and 2.4mos (p = 0.01, HR = 0.57, p = 0.006, HR = 0.54, respectively). Treatment extended PFS with sustained QoL assessed by FACT-BR, KPS, and steroid usage. The frequency of HLA-A2 primary tumor antigen expression was higher than that for HLA-A1 patients, and HLA-A2 patients had higher vaccine response (via Elispot) than HLA-A1 patients. PP HLA-A2 patients in both the MGMT methylated and unmethylated pre-specified subgroups saw a clinically meaningful ICT-107 effect, although HLA-A1 patients received no benefit from vaccine. CONCLUSIONS: PFS was significantly improved in ICT-107 treated patients with maintenance of QoL. Patients in the HLA-A2 MGMT subgroups show stronger ICT-107 activity clinically and immunologically, and these groups will be studied in a future phase 3 trial.
FDG PET/CT in IgG4-Related Peripulmonary Arteritis
Authors: Aisheng Dong, Yang Wang, Changjing Zuo
Journal: Clinical Nuclear Medicine (2016)

IgG4-related peripulmonary arteritis is rare. A 60-year-old woman presented with fatigue for more than 2 years. Transthoracic echocardiography revealed a lesion measuring 2.1 × 1.5 cm in the pulmonary artery bifurcation. CT pulmonary angiography showed marked stenosis of the right and left pulmonary arteries. FDG PET/CT showed increased FDG uptake of the thickened walls in the bilateral pulmonary arteries with SUVmax of 5.8. The patient underwent partial resection of the pulmonary artery lesion. IgG4-related peripulmonary arteritis was confirmed by pathology.
Linkage Heterogeneity of Autosomal Dominant Polycystic Kidney Disease
Authors: William J. Kimberling, Pamela R. Fain, J.B. Kenyon, David Goldgar, Eva Sujansky, Patricia A. Gabow
Journal: New England Journal of Medicine (1988)

Autosomal dominant polycystic kidney disease has been shown to be closely linked to the alpha-hemoglobin complex on the short arm of chromosome 16. We describe a five-generation kindred, descendants of Sicilian immigrants, in which the disease occurs but without linkage to the alpha-hemoglobin complex. DNA probes were used in genetic-linkage studies on blood samples from 163 family members, of whom 71 were affected by or at risk for autosomal dominant polycystic kidney disease. Diagnoses were confirmed by ultrasound examination. In this family the frequency of recombination between the alpha-hemoglobin complex and the region previously shown to contain the mutation causing polycystic kidney disease exceeded 24 percent, indicating a mutation at a different locus. The clinical findings in this family were indistinguishable from those in other families with polycystic kidney disease. We conclude that there is a second gene for autosomal dominant polycystic kidney disease. This apparent heterogeneity means that prenatal and presymptomatic diagnosis must be approached with caution until a method is found to distinguish between the two forms of the disease.
AB0684 Comparison of Two Referral Strategies for the Diagnosis of Axial Spondyloarthritis in Romania: the Rabbit Study
Authors: C.M. Ancuta, C. Pomirleanu, D. Opris, R. Chirieac, C. Codreanu, M. Bojinca, S. Rednic, R. Ionescu
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Despite recent advances in classifying and diagnosing axial spondyloarthropathies (SpA), screening of patients with chronic low back pain and referral from the primary care settings remain unsatisfactory. <h3>Objectives</h3> RADAR study aimed to identify the best referral strategy for diagnosing axial SpA in patients with chronic back pain (CBP). <h3>Methods</h3> Hundred-and-six Romanian patients with CBP occurring before 45 years were assigned to either a simple (any of inflammatory back pain, HLA-B27 positivity or sacroiliitis on imaging) (38 patients) or a complex referral strategy (two of inflammatory back pain, HLA-B27, sacroiliitis, familial SpA history, extra-articular manifestations, good response to nonsteroidal antiinflammatory drugs) (68 patients). Primary end points were to compare the percentage of patients diagnosed with definite axial SpA by referral strategy and the degree of concordance of selection criteria between referring physicians and rheumatologists. <h3>Results</h3> Final analysis was performed in hundred-and-three patients (37 per strategy 1, 66 per strategy 2); definite axial SpA was established in 70.3% and 65.2% patients by referral strategies, mostly in the radiographic disease (56.8% and 54.5%). The first three commonly used for referral were inflammatory back pain (99.1%) with 83.2% concordance rate with rheumatologists, 89% positive predictive value, 94.2% sensitivity, 57.9% specificity; response to NSAIDs (50.9%) with 90.4% concordance rate, 79.7% positive predictive value, 80.9% sensitivity, 26.3% specificity; and sacroiliitis (48.1%), 72.9% concordance rate, 75% sensitivity <h3>Conclusions</h3> Both referral strategies showed comparable effectiveness in diagnosing patients with axial SpA; a simple screening strategy using three criteria should be routinely used in primary care settings in recognizing axial SpA. <h3>Acknowledgements</h3> This study was supported by a grant from Schering-Plough (presently Merck &amp; Co Inc, Whitehouse Station, New Jersey, USA). <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5577
Factors Associated with Early Remission of Type I Diabetes in Children Treated with Cyclosporine
Authors: P F Bougneres, J C Carel, L Castano, C Boitard, J P Gardin, P Landais, J Hors, M J Mihatsch, M Paillard, J L Chaussain
Journal: New England Journal of Medicine (1988)

To improve criteria for entry into future trials of immunosuppression, we enrolled 40 children with recent-onset Type I insulin-dependent diabetes in a pilot trial of cyclosporine. Twenty-seven patients were able to discontinue insulin therapy 48 +/- 5 days after the start of immunosuppression. At four months, their fasting and postprandial blood glucose concentrations averaged 110 and 160 mg per deciliter (6.1 and 8.9 mmol per liter) with a mean hemoglobin A1c level of 6.15 percent. Seventy-five percent of these patients with early remission still did not need insulin at 12 months, and their glycemic control was similar to that at 4 months. The major differences between the 27 patients with remission and the 13 without remission were the duration of symptoms before diagnosis (26.8 vs. 48.0 days, P less than 0.01), the degree of weight loss (3.2 vs. 10 percent of body weight, P less than 0.001), the initial hemoglobin A1c level (10.7 vs. 13.2 percent, P less than 0.001), and the frequency of ketoacidosis (11 vs. 61.5 percent, P less than 0.001). The lesser degree of weight loss was the strongest independent predictor of remission. The response of C-peptide to intravenous glucagon (0.50 vs. 0.17 pmol per milliliter, P less than 0.05) was also an independent predictor. No differences were observed between the two groups of patients in age, sex, HLA phenotype, autoantibodies to insulin or islet-cell antigens, or doses or trough levels of cyclosporine. Only minimal manifestations of toxicity were detected over the period of observation. We conclude that early treatment with cyclosporine in children with recent-onset Type I diabetes can induce remission from insulin dependence, with half the patients not requiring insulin after a full year.
The Diagnosis and Treatment of Baroreflex Failure
Authors: David Robertson, Alan S. Hollister, Italo Biaggioni, James L. Netterville, Rogelio Mosqueda-Garcia, Rose Marie Robertson
Journal: New England Journal of Medicine (1993)

Baroreflexes originate in the great vessels of the neck and thorax and prevent arterial pressure from rising or falling excessively.This study was undertaken to clarify the cause, clinical spectrum, and therapy of this disorder. We studied 11 patients with baroreflex failure presenting as severe, labile hypertension and hypotension, often with headache, diaphoresis, and emotional instability, and characterized by the failure of exogenous vasoactive substances to alter heart rate. Each underwent hemodynamic monitoring and biochemical, physiologic, and pharmacologic testing.The patients' maximal systolic blood pressures ranged from 164 to 280 mm Hg, and their minimal systolic pressures ranged from 58 to 96 mm Hg. Plasma norepinephrine and epinephrine concentrations were sometimes many times normal during blood-pressure surges. All the patients had excessive pressor and tachycardia responses to the mental-arithmetic and cold pressor tests and marked hypersensitivity to clonidine. The underlying causes of baroreflex failure included the familial paraganglioma syndrome, neck surgery or radiation therapy for pharyngeal carcinoma, bilateral lesions of the nucleus tractus solitarii, and surgical section of the glossopharyngeal nerves; in two patients the cause was unknown. Therapy with clonidine reduced the frequency of attacks by 81 percent and attenuated the elevated blood pressure and heart rate in the attacks that occurred.The syndrome of baroreflex failure should be considered in patients with otherwise unexplained labile hypertension. Clonidine attenuates the pressor and tachycardic surges in baroreflex failure.
Age as a Factor in the Distribution of Lower-Airway Conductance and in the Pathologic Anatomy of Obstructive Lung Disease
Authors: J. C. Hogg, J. Williams, J. B. Richardson, P. T. Macklem, W. M. Thurlbeck
Journal: New England Journal of Medicine (1970)

Measurements with a retrograde catheter technic showed little change with age in the conductance of airways central to those of the twelfth to the fifteenth generation. Conductance of peripheral airways, on the other hand, rose sharply at about five years of age. Morphologic measurements suggested that changes in the linear dimension of peripheral airways were responsible for the increase observed. Lower-airway disease appeared to be a common factor in bronchiolitis, fibrocystic disease and bronchiectasis. The age of the patient may determine to a large extent the type of resulting anatomic disorder.
A Prospective Study of Moderate Alcohol Consumption and the Risk of Coronary Disease and Stroke in Women
Authors: Meir J. Stampfer, Graham A. Colditz, Walter C. Willett, Frank E. Speizer, Charles H. Hennekens
Journal: New England Journal of Medicine (1988)

In 1980, 87,526 female nurses 34 to 59 years of age completed a dietary questionnaire that assessed their consumption of beer, wine, and liquor. By 1984, during 334,382 person-years of follow-up, we had documented 200 incident cases of severe coronary heart disease (164 nonfatal myocardial infarctions and 36 deaths due to coronary disease), 66 ischemic strokes, and 28 subarachnoid hemorrhages. Follow-up was 98 percent complete. As compared with nondrinkers, women who consumed 5 to 14 g of alcohol per day (three to nine drinks per week) had a relative risk of coronary disease of 0.6 (95 percent confidence interval, 0.4 to 0.9); for 15 to 24 g per day the relative risk was 0.6 (0.3 to 1.1), and for 25 g or more per day it was 0.4 (0.2 to 0.8), after adjustment for risk factors for coronary disease. Alcohol intake was also associated with a decreased risk of ischemic stroke. For 5 to 14 g of alcohol per day the relative risk was 0.3 (0.1 to 0.7), and for 15 g per day or more it was 0.5 (0.2 to 1.1). In contrast, although the number of cases of subarachnoid hemorrhage was small, alcohol intake tended to be associated with an increased risk of this disorder; for 5 to 14 g per day the relative risk was 3.7 (1.0 to 13.8). These prospective data suggest that among middle-aged women, moderate alcohol consumption decreases the risks of coronary heart disease and ischemic stroke but may increase the risk of subarachnoid hemorrhage. (N Engl J Med 1988; 319:267–73.)
Case 30-2009
Authors: Donald S. Kaufman, W. Scott McDougal, Mukesh G. Harisinghani, Chin-Lee Wu
Journal: New England Journal of Medicine (2009)

A 77-year-old man was seen at this hospital because of a mass in the left ureter and cytologic examination of a urine specimen that was positive for transitional-cell carcinoma. Eight years earlier, right nephroureterectomy was performed because of transitional-cell carcinoma of the right renal pelvis. Several years later, cytologic examination of urine specimens was positive for transitional-cell carcinoma, but no tumor was evident on examination until 10 months before evaluation, when circumferential thickening of the left ureter was seen on imaging studies. A management decision was made.
SP0189 Induction of Remission by Low-Dose IL-2-Therapy in One SLE Patient with Increased Disease Activity Refractory to Standard Therapies
Authors: J.Y. Humrich
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> IL-2 deficiency and associated regulatory T cell (Treg) defects critically contribute to SLE pathogenesis. In our previous translational work we proved the efficacy and safety of a low-dose IL-2 therapy in animal models and identified a reversible IL-2 deprivation of Treg also in human SLE patients. Together, these studies provided the rationales for an IL-2-based immunotherapy of SLE in order to restore Treg activity and thus to re-establish endogenous mechanisms of tolerance that can counteract autoimmunity. Here we report that a cyclic and subcutaneously applied low-dose IL-2-therapy induced a rapid, strong and sustained reduction of disease activity in parallel to a remarkable and selective expansion of the Treg population in a SLE patient with increased disease activity (SELENA-SLEDAI 14) refractory to a large variety of approved and experimental therapies. Already after the first therapeutic cycle, signs of arthritis and later also myositis and active skin eruptions disappeared. In addition, levels of anti-dsDNA antibodies dramatically declined (ELISA) or even turned negative (Crithidia IFT). Throughout the residual three therapeutic cycles, organ manifestations remained absent and disease activity remained low with a SELENA-SLEDAI of 4. In addition, the daily dose of glucocorticosteroids could be reduced from 30 mg/d at baseline to 10 mg/d after the 4th and last therapeutic cycle. The therapy was very well tolerated and adverse events were minimal suggesting that this therapy is very safe in SLE patients. In summary, these data provide the first evidence for the clinical efficacy and safety of a subcutaneous low-dose IL-2-therapy in conjunction with the <i>in vivo</i> augmentation of Treg activity in SLE patients and strongly support the rationales of this biologic and patho-physiologically-driven therapeutic approach. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6341
The Immunobiology of Eosinophils
Authors: Jeffrey S. Flier, Lisa H. Underhill, Peter F. Weller
Journal: New England Journal of Medicine (1991)

EOSINOPHILS, like neutrophils and basophils, are a type of granulocyte derived from bone marrow, distinguished by their morphologic features, constituents, products, and associations with specific diseases. The original denominating property of eosinophils was the cardinal affinity of their cytoplasmic granules for acid aniline dyes, such as eosin. Eosinophils contain several eosinophil-specific proteins in their cytoplasmic granules, yet to date no cell-surface proteins unique to eosinophils have been recognized. Thus, tinctorial properties remain the routine basis for identifying and enumerating these leukocytes in blood and tissues. Eosinophilia, characterized by both heightened production of eosinophils in bone marrow and the accumulation of . . .
Idiopathic Thrombopenic Purpura in Childhood
Authors: William A. Newton, Wolf W. Zuelzer
Journal: New England Journal of Medicine (1951)

THE syndrome of "idiopathic" or "primary" thrombopenic purpura has been discussed by a number of authors,1 2 3 4 but these studies usually have included all age groups or have used large subdivisions of age ranges. The condition as it is seen in childhood has not been dealt with specifically or in detail for some time. McLean5 in 1932 reported a short follow-up study of 21 cases, and Diamond6 briefly summarized the results of therapy in 28 cases in 1938. Since then, except for studies on congenital purpura,7 no comprehensive publications have appeared on thrombopenic purpura in childhood.This paper reports on 47 . . .