tbuckley/cabot-search huggingface dataset:
Assessment of viable myocardium within infarct zone by exercise thallium-201 scintigraphy.
Authors: Makoto Kondo, Schunichi Miyazaki, Mamoru Takahashi, Yukio Shimono
Journal: Circulation (1984)

The viability of the myocardial regions corresponding to pathologic Q waves was evaluated. Thirty-four patients with prior myocardial infarction underwent serial thallium-201 scintigraphy during treadmill exercise testing. On the delayed images, 8 of the initial 85 segmental defects (8 patients, 9%) showed total redistribution (RD) and 11 (6 patients, 13%) showed partial RD. In contrast, 66 segments showed persistent defect. The segments with total RD were more likely to be associated with normal or hypokinetic wall motion than the segments with persistent defect (p less than 0.05). Six of the 38 segments (13%) with collateral vessels showed total RD and 10 (21%) showed partial RD. However, 35 of 38 segments (92%) without collateral vessels showed persistent defect. There was a significant difference (p = 0.02) in myocardial thallium uptake patterns when the segments with and without collateral vessels were compared. It is concluded that (1) exercise-induced thallium RD may occur in patients with prior myocardial infarction, and myocardial infarct regions with total RD are highly associated with good contractility; these suggest the presence of viable but jeopardized myocardium within the infarct zone, and (2) collateral vessels may play a role in limiting infarct size.
P3.02b-080 Analysis of Patient-Reported Symptom Response with Osimertinib (AZD9291) Treatment for Advanced Non-Small-Cell Lung Cancer
Authors: Silvia Novello, Katja Rüdell, Carolyn Bodnar, Sarah Vowler, Tina Rupnik, Serban Ghiorghiu
Journal: Journal of Thoracic Oncology (2017)
Defining blast characteristics in relapsed childhood acute lymphoblastic leukemia using gene expression profiling
Authors: D. Bhojwani, D.-J. J. Min, D. Viswanatha, E. Raetz, C. L. Willman, W. Carroll
Journal: Journal of Clinical Oncology (2004)

8502 Background: Despite significant advances in the treatment of childhood acute lymphoblastic leukemia (ALL), one in four children still relapse. Treatment for relapsed ALL remains unsatisfactory, especially for early marrow relapse, where survival is less than 10%. Understanding the biological factors that render the relapsed blast refractory to conventional therapy using techniques like DNA microarrays may help in refining treatment and improving outcome. Methods: Total RNA was purified from 30 bone marrow samples from patients with newly diagnosed B-precursor ALL, treated on Pediatric Oncology Group trials, and 12 marrow samples from patients with initial marrow relapses treated on the current Children's Oncology Group (COG) AALL01P2 study. All samples were obtained from COG tumor banks and Reference Laboratories. RNA was amplified, labeled and hybridized to the Affymetrix U-133A microarrays. The data was analyzed by Robust Multichip Analysis and clustered using Genetraffic software. Significant genes were identified by Prediction Analysis for Microarrays (PAM)(Tibshirani et al; PNAS 2002). A ten-fold balanced cross-validation was completed to minimize classification errors. Results: Unsupervised clustering of the samples, using all 22,283 probe sets showed two distinct clusters, inferring clear differences between the two cohorts. Next, we identified the top 22 genes that best differentiated diagnostic and relapsed ALL samples using PAM, a supervised statistical approach. This set of genes accurately classified samples from each cohort with an overall misclassification error rate of zero. Genes predominantly over-expressed in the relapsed samples included genes involved in cell growth (RANBP9), cell cycle regulation (GSK3B), and DNA synthesis (SFRS5, SET). Conclusions: Differentially expressed genes identified by DNA arrays may provide insight into the biology of relapse and serve as targets for new treatment strategies in the future. Ongoing analysis of samples from COG AALL01P2 will validate and expand on these early results. No significant financial relationships to disclose.
PUB064 Correlation between Estrogen Receptor Alpha and Beta and the Markers Coexpression in Non-Small Cell Lung Cancer (NSCLC) Tissue
Authors: Evgeniya Ponomarenko, Evgeny Dudko, Tatiana Bogush, Dmitriy Novikov, Olga Rjabinina, Anna Basharina, Elena Bogush, Boris Polotsky, Mikhail Davydov, Mikhail Davydov
Journal: Journal of Thoracic Oncology (2017)
P3.02b-032 Association between EGFR T790M Mutation Copy Numbers in Cell-Free Plasma DNA and Response to Osimertinib in Advanced NSCLC
Authors: Anna Buder, Maximilian Hochmair, Sophia Holzer, Andrea Mohn-Staudner, Peter Errhalt, Tatjana Bundalo, Peter Schenk, Ulrike Setinek, Otto Burghuber, Robert Pirker, Martin Filipits
Journal: Journal of Thoracic Oncology (2017)
Bortezomib + Low Dose Cytarabine in Int-2 and High Risk MDS. Interim Results of a Phase I/II Trial by the GFM.
Authors: Shanti Natarajan, Pierre Fenaux, Norbert Vey, A. Guerci, I. Coulibaly, A. Charbonnier, C. Ravoet, S. Courby, G. Etienne, M.P. Chaury, S. Cheze, A. Stamatoullas, L. Legros, E. Berger, A. Lescoute, S. Vaultier, F. Dreyfus
Journal: Blood (2007)
P14 Examining the outcomes of a pleural disease clinic
Authors: DT Whitehall, JB McCafferty
Journal: Thorax (2016)

<h3>Background</h3> Pleural effusions, the result of the accumulation of fluid in the pleural space, are a common medical problem. Patients with symptoms of cough and breathlessness with associated signs and chest x-ray (CXR) changes suggestive of a pleural effusion commonly present acutely to the medical assessment unit or to the respiratory outpatient department. Pleural effusions may also develop during admission. Advances in the availability of pleural diagnostic techniques, including thoracic ultrasound, thoracocentesis kits, and medical thoracoscopy means that pleural expertise can be concentrated in a dedicated clinic with the aim of facilitating ambulatory care, reducing hospital admissions and rationalising the use of laboratory services. This study aimed to assess the impact of a dedicated pleural clinic on these factors. <h3>Methods</h3> A retrospective analysis of the hospital electronic patient records was carried out on patients attending the pleural clinic from 2014 to 2016. 146 patients were identified. Hospital admission data was also evaluated to assess inpatient admission for pleural effusion before and after the pleural clinic was instituted. In addition, quantification of laboratory samples sent pre- and post-pleural clinic was carried out. <h3>Results</h3> Malignant disease was diagnosed in 44% of cases versus 46% for benign disease. A 29% reduction in ward admissions for pleural effusion was seen over 2 years. With a median length of stay of 5 days this resulted in 175 bed days saved in 205 with an associated annual cost saving of approximately £87,000. The number of diagnostic samples sent for cytology dropped by 11% following the introduction of the pleural clinic with estimated annual cost savings of around £3000. <h3>Conclusions</h3> The introduction of a pleural clinic is not only cost effective in reducing hospital admissions and optimising diagnostic costs but also improves the patient journey by facilitating ambulatory care wherever possible.
Reduced-Intensity Conditioning for Allograft (RICT) after Cytoreductive Autograft (ASCT) in Relapsed/Resistant Hodgkin’s Lymphoma (HL)
Authors: A. M. Carella, E. Todisco, L. Castagna, A. Santoro, G. Catania, S Nati, A Congiu, R Vimercati, E Rossi, M Spriano, R Varaldo
Journal: Blood (2008)
P2.03b-084 Profiling of Eph Signaling in Malignant Pleural Effusions- Identification of Therapy Approaches and Associated Biomarkers
Authors: Metka Novak, Petra Hååg, Katarzyna Zielinska Chomej, Xiaoyan Qian, Luigi De Petris, Simon Ekman, Per Hydbring, Caroline Kamali, Lena Kanter, Magnus Löfdahl, Mats Nilsson, Kristina Viktorsson, Rolf Lewensohn
Journal: Journal of Thoracic Oncology (2017)
Transposition of the Great Arteries in the Developing World
Authors: David N. Schidlow, Kathy J. Jenkins, Kimberlee Gauvreau, Ulisses A. Croti, Do Thi Cam Giang, Rama K. Konda, William M. Novick, Nestor F. Sandoval, Aldo Castañeda
Journal: Journal of the American College of Cardiology (2017)
Mutations in the D1 Domain Inhibit Propeptide-Dependent Multimerization, Trafficking and Regulated Secretion of Von Willebrand Factor in VWD
Authors: Jie Yin, Zhenni Ma, Jian Su, Xiaojuan Zhao, Zhaoyue Wang, Ziqiang Yu, Wanyan Ouyang, Xia Bai, Changgeng Ruan
Journal: Blood (2014)
Impaired Viability, Platelet Survival, Morphology and Function in Mice Lacking Filamin A.
Authors: Herve Falet, Michael P. Marchetti, Karin M. Hoffmeister, Joseph E. Italiano, Yuanyi Feng, Thomas P. Stossel, David J. Kwiatkowski, Christopher A. Walsh, John H. Hartwig
Journal: Blood (2006)
MA05.01 Virtual Bronchoscopic Navigation-Guided Ultrathin Bronchoscopy for Diagnosing Peripheral Pulmonary Lesions
Authors: Marta Diez-Ferrer, Arturo Morales, Noelia Cubero, Rosa Lopez-Lisbona, Nikos Koufos, Jordi Dorca, Antoni Rosell
Journal: Journal of Thoracic Oncology (2017)
P3.02a-012 Patient-Reported Symptoms and Quality of Life (QoL) in East Asian Patients with ALK+ NSCLC Treated with Crizotinib vs Chemotherapy
Authors: You Lu, Jianying Zhou, Chin-Hee Chung, Elizabeth Masters, Keith Wilner, Paulina Selaru, Yiyun Tang, Yi Long Wu
Journal: Journal of Thoracic Oncology (2017)
P1.01-058 Demographic Profile of Lung Cancer from Eastern India
Authors: Prasanta Mohapatra, Sourin Bhuniya, Manoj Panigrahi, Susama Patra, Pritinanda Mishra, Gourahari Pradhan, Saroj Das Majumdar, Priyadarshini Behera, Dillip Muduly, Madhabananda Kar
Journal: Journal of Thoracic Oncology (2017)
Sensitivity and Applicability of Six-Color Flow Cytometry Is Comparable to ASO-Primer-Real-Time PCR (RQ-PCR) for Minimal Residual Disease (MRD) Monitoring in Adult Acute Lymphoblastic Leukemia (ALL) - A Comparative Analysis in 70 Patients from the German Multicenter Study Group for Adult Acute Lymphoblastic Leukemia (GMALL).
Authors: Sebastian Boettcher, Sebastian Irmer, Silke Lueschen, Matthias Ritgen, Thorsten Raff, Nicola Goekbuget, Dieter Hoelzer, Heinz-August Horst, Michael Kneba, Monika Brueggemann
Journal: Blood (2006)
Screening for Leptomeningeal Disease by High-Sensitivity Flow Cytometry in High Risk Patients with Aggressive Non-Hodgkin’s Lymphoma.
Authors: Joy Mangel, Jazmin Marlinga, Mike Keeney, Jan Popma, Anargyros Xenocostas, Kang Howson-Jan, Kamilia Rizkalla, Ian Chin-Yee
Journal: Blood (2007)
P88 Follow-up after surgical treatment of lung cancer: the potential impact of international guidelines on current uk practice
Authors: J Capps, V Grannon, S Baksi, S Khalid
Journal: Thorax (2016)

<h3>Introduction and objectives</h3> International guidelines suggest regular CT scan follow-up for non-small-cell lung cancer (NSCLC) that is surgically treated with curative intent.<sup>1,2</sup> NICE guidance does not specify the type or frequency of imaging. Our aims were to assess current follow-up practice in such patients in our region, and estimate the potential impact of implementing international guidelines. <h3>Methods</h3> We surveyed a majority of hospitals (six NHS trusts) in our region about their current follow-up practice. A retrospective study was performed of patients in our trust who underwent curative surgery for NSCLC between March 2013 and December 2014. <h3>Results</h3> None of the surveyed trusts were following ESMO or ACCP guidelines. Only two had a local policy in place. The majority used chest X-ray (CXR) rather than CT follow-up, which reflected our practice. We identified 79 patients who had undergone surgery with curative intent in our trust. 5 patients were excluded, as notes were unavailable for 2, and 3 died before any follow-up. Amongst the remaining 74 patients, follow-up was for a mean of 19 months. During this time the mean number of CTs and CXRs per patient was 1.3 and 2.7 respectively. Following ESMO guidelines would reduce the number of CT scans compared to our overall current practice, to 1.1 per patient,<sup>1</sup> whilst ACCP guidelines would result in an increase to 2.7 CTs per patient.<sup>2</sup> <h3>Conclusions</h3> Most patients in our region are followed-up by CXR rather than CT. Most hospitals are not using follow-up guidelines, resulting in practice variation. Compared to current practice in our trust, following ESMO guidelines would not result in an increase in CT scans for this purpose, and no CXRs would be required for routine follow-up. Therefore it may be feasible to adopt this more uniform, evidence-based approach. <h3>References</h3> Vansteenkiste J, Crino L, Dooms C, <i>et al</i>. 2nd ESMO Consensus Conference on Lung Cancer: early-stage non-small-cell lung cancer consensus on diagnosis, treatment and follow-up. <i>Annals of Oncology</i> 2014;<b>25</b>:1462–1474. Colt H, Murgu S, Korst R, <i>et al</i>. Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. <i>Chest</i> 2013;<b>143</b>(5 Suppl):e437S–e454S.
P3.02c-072 Predictive Immunologic Markers of Response to Nivolumab in Non-Small Cell Lung Cancer
Authors: Carlo Genova, Paolo Carrega, Roberta Distefano, Selene Ottonello, Gabriella Pietra, Irene Cossu, Erika Rijavec, Federica Biello, Giovanni Rossi, Giulia Barletta, Maria Giovanna Dal Bello, Angela Alama, Simona Coco, Irene Vanni, Claudia Maggioni, Franco Merlo, Maria Cristina Mingari, Francesco Grossi
Journal: Journal of Thoracic Oncology (2017)
The Synthetic Pentasaccharide, Fondaparinux, Reduces Inflammation and Neutrophil Accumulation in Kidney Ischemia-Reperfusion Injury.
Authors: Gernot Schabbauer, Rolf D. Frank, Todd Holscher, Yuichiro Sato, Michael Tencati, Rafal Pawlinski, Nigel Mackman
Journal: Blood (2004)
Diffuse Pattern of Bone Marrow Involvement in MRI Is Associated with High Risk Cytogenetics and Poor Outcome in Newly Diagnosed, Symptomatic Patients with Multiple Myeloma,
Authors: Lia A Moulopoulos, Efstathios Kastritis, Evangelos Terpos, Maria Gkotzamanidou, Maria Roussou, Andreas Koureas, Magdalini Migkou, Maria Gavriatopoulou, Dimitra Gika, Vasilios Koutoulidis, Meletios Athanasios Dimopoulos
Journal: Blood (2011)
Preoperative prediction of the axillary lymph nodes status in patients with breast cancer
Authors: E. Angelidou, G. Sotiropoulou, E. Poulianou, E. Politi, H. Koutselini
Journal: Journal of Clinical Oncology (2006)

10547 Background: We developed a preoperative score-system (S) and evaluated prospectively its predictive value for the axillary(a) status of patients (p) with breast cancer. Our aim was to select preoperatively (p) with negative axilla, who could possibly avoid the standard (a) surgery. (S) uses preoperative clinical, epidemiological and immunocytological data, obtained from the FNA-smears of (p)‘ tumors, and attempts to guide the choice of (a) treatment, as an alternative to the method of sentinel lymph node. Methods: (S) is calculated by adding the preoperative values of clinical tumor size, (p) age, nuclear grade (NG), type of the cancer cells and the immunocytochemical positiveness of the biomarkers p53, HER2 and MIB1. Values range from 1–4 for size (1–10, 11–15, 16–20, 20–30 mm), 1 to 4 for age (70 and over, 51–69, 41–50, 40 years or less), 1–3 for NG1–3, 1–2 for type of cancer cells (lobular, ductal) respectively and 0–3 for the expression (1 point for every positive biomarker) or absence (0) of p53, HER2 and MIB1 in the FNA of the primary tumors of the (p). (S) ranges from 4 to 16.We applied (S) to 224 (p), with clinically negative axilla. These (p) underwent modified radical mastectomy or lumpectomy and standard (a) dissection level I and II. The number of the infiltrated nodes was identified in each case. Results: (S) of 4 - 8 (57 patients, group 1) identify (p) with free nodes ( node positive rate 0%). (S) of 9 and 10 (67 patients, group 2) carry an average node positive rate of 65,67%, of which 31,34% involves the invasion of 1 node, 23,88% of 2–3 and 10,44% of 4 or more nodes (P &lt; 0.001, group 1 versus group 2). (S) of 11 and more (100 patients, group 3) identify (p) with an average node positive rate of 83%, of which 55% involves the invasion of 4 or more nodes (P &lt; 0.001, group 3 versus group 1). (S) allows the separation of (p) into two (a) management groups. Group 1 are those (p), who possibly have free lymph nodes and therefore may need no (a) surgery at all, whereas group 2 and 3 may be considered for standard (a) dissection, because they present with increased possibility infiltrated nodes. Conclusion: (S) was studied to aid the selection of (p) towards reasonable (a) treatment choices for the benefit of (p). (S) might serve as a guideline in the clinical practice to reduce the postoperative morbidity of the breast cancer (p). No significant financial relationships to disclose.
The Balance in Chimerism between T Cells and Blood Dendritic Cells in Relapsed CML Patients Influences the Induction of Alloreactivity Following Donor Lymphocyte Infusion.
Authors: Henriette Levenga, Rob Woestenenk, Antonius V.M.B. Schattenberg, Frans Maas, Joop H. Jansen, Reinier Raymakers, Pieter H.M. De Mulder, Nicolaas Schaap, T.M. de Witte, Harry Dolstra
Journal: Blood (2006)
Intriguing structure of the HCV particle
Authors: Agata Budkowska
Journal: Gut (2017)

HCV is a major cause of chronic liver disease worldwide. Much has been learned about HCV since its discovery 27 years ago by molecular cloning when standard virological methods failed to identify this important human pathogen. Elaboration of in vitro models enabled studies of the HCV life cycle and a search for inhibitors of viral replication, leading to the development of effective therapies of chronic HCV infection based on direct-acting antivirals with cure rates of more than 95%.

Despite of the tremendous success of HCV therapy and substantial progress in our knowledge of the virus life cycle, the structure, composition and morphogenesis of HCV particles circulating in the blood of infected patients still remain elusive and determination of the ultrastructure of HCV particles by electron microscopy is a significant challenge.

The putative infectious HCV particle consists of a nucleocapsid-containing the single-stranded RNA genome associated with the viral core protein and a lipid bilayer where the viral envelope proteins (E1 and E2) are assembled as heterodimers. In reality, the structure of HCV is more complex and the virus exhibits unusual and striking features. Indeed, a hallmark of HCV particles is their association with host-cell lipids and lipoproteins, mainly very low-density lipoproteins (VLDL) and low-density lipoproteins (LDL).1 ,2 Thus, virus particles in patients' sera …
A bioengineered living cell construct activates an acute wound healing response in venous leg ulcers
Authors: Rivka C. Stone, Olivera Stojadinovic, Ashley M. Rosa, Horacio A. Ramirez, Evangelos Badiavas, Miroslav Blumenberg, Marjana Tomic-Canic
Journal: Science Translational Medicine (2017)

Chronic nonhealing venous leg ulcers (VLUs) are widespread and debilitating, with high morbidity and associated costs; about $15 billion is spent annually on the care of VLUs in the United States. Despite this, there is a paucity of treatments for VLUs because of the lack of pathophysiologic insight into ulcer development as well as the lack of knowledge regarding biologic actions of existing VLU-targeted therapies. The bioengineered bilayered living cellular construct (BLCC) skin substitute is a U.S. Food and Drug Administration-approved biologic treatment for healing VLUs. To elucidate the mechanisms through which the BLCC promotes healing of chronic VLUs, we conducted a clinical trial (NCT01327937) in which patients with nonhealing VLUs were treated with either standard of care (compression therapy) or the BLCC together with standard of care. Tissue was collected from the VLU edge before and 1 week after treatment, and the samples underwent comprehensive microarray mRNA and protein analyses. Ulcers treated with the BLCC skin substitute displayed three distinct transcriptomic patterns, suggesting that BLCC induced a shift from a nonhealing to a healing tissue response, involving modulation of inflammatory and growth factor signaling, keratinocyte activation, and attenuation of Wnt/β-catenin signaling. In these ways, BLCC application orchestrated a shift from the chronic nonhealing ulcer microenvironment to a distinctive healing milieu resembling that of an acute, healing wound. Our findings provide in vivo evidence in VLU patients of pathways that can be targeted in the design of new therapies to promote healing of chronic VLUs.
P3.02c-092 Nivolumab in Multi-Treated Patients with Advanced Sq-NSCLC: Data from the Italian Cohort of Expanded Access Programme (EAP)
Authors: Marcello Tiseo, Lucio Crinò, Domenico Galetta, Maria Ida Abbate, Angelo Delmonte, Francesco Grossi, Filippo De Marinis, Serena Ricciardi, Anna Manzo, Antonio Palla, Carlo Tondini, Davide Tassinari, Antonio Frassoldati, Francesco Verderame, Alessio Aligi Cogoni, Francesco Cognetti, Gennaro Palmiotti, Alfonso Illiano, Franco Silvestris, Hector Josè Soto Parra
Journal: Journal of Thoracic Oncology (2017)
The Wiskott-Aldrich-Syndrome family member 1 (WASF1) gene on 6q21 is down-regulated in specific AML cytogenetic subtypes.
Authors: S. Debernardi, Frederik W. Van Delft, A Davies, Debra Lillington, M Smith, Ta. Lister, V Saha, B D Young, J. Fitzgibbon
Journal: Blood (2003)
Activity of Serono-AS703569, a Dual Inhibitor of Bcr-Abl and Aurora Kinases in Bcr-Abl Transformed Cells, Is Dependent On Aurora B Inhibition, and Is Not Affected by the Presence of the Highly Imatinib Resistant Bcr-Abl Mutation T315I.
Authors: Anna Katharina Seitz, Nikolas von Bubnoff, Samantha M. Sarno, Christian Peschel, Justus Duyster
Journal: Blood (2009)
Role of Protein Kinase CK2 in the Retinoic Acid-Induced Differentiation of Acute Promyelocytic Leukemia Cells.
Authors: Carmela Gurrieri, Francesco A. Piazza, Maria Ruzzene, Laura Quotti Tubi, Kendra Tosoni, Marianna Gnoato, Anna Cabrelle, Luca Bonanni, Livio Trentin, Renato Zambello, Giorgio Arrigoni, Lorenzo A. Pinna, Gianpietro Semenzato
Journal: Blood (2007)
Transplant-Associated Thrombotic Microangiopathy (TAM): A Study Comparing Hemopoietic Stem Cells (HSCT) and Solid Organ (SO) Transplant (TX) Recipients.
Authors: Dolores Puente, Maria Tabares, Alejandro Requejo, Colorio Cecilia, Nicolas Bonini, Andrea Rossi, Viviana Listello, Vera Milovic, Gregorio Jaimovich, Gonzalo Pombo, Leonardo Feldman
Journal: Blood (2006)