tbuckley/cabot-search huggingface dataset:
Distinct mutations at the same positions of STAT3 cause either loss or gain of function
Authors: Prabha Chandrasekaran, Ofer Zimmerman, Michelle Paulson, Elizabeth P. Sampaio, Alexandra F. Freeman, Kathryn J. Sowerwine, Darell Hurt, Julio C. Alcántara-Montiel, Amy P. Hsu, Steven M. Holland
Journal: Journal of Allergy and Clinical Immunology (2016)
A Randomized Phase Ii Trial of Cisplatin Plus Gemcitabine Versus Carboplatin Plus Gemcitabine in Patients with Completely Resected Non-Small Cell Lung Cancer: Hokkaido Lung Cancer Clinical Study Group Trial (Hot0703)
Authors: T. Harada, S. Fukumoto, M. Harada, K. Nakano, N. Sukoh, S. Fuke, H. Asahina, K. Takamura, M. Yamamoto, Y. Fujita, K. Akie, I. Kinoshita, S. Oizumi, H. Akita, H. Isobe, M. Nishimura
Journal: Annals of Oncology (2014)
Abstract A33: Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcemic type.
Authors: Anthony N. Karnezis, Yemin Wang, Pilar Ramos, William Hendricks, Holly Yin, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa R. Nucci, Torsten O. Nielsen, Bernard E. Weissman, Jeffrey M. Trent, C Blake Gilks, David G. Huntsman
Journal: Clinical Cancer Research (2016)

Abstract Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a lethal and sometimes familial ovarian tumor of young women and children. We and others recently discovered that over 90% of SCCOHT harbor inactivating mutations in the chromatin remodeling gene SMARCA4 with concomitant loss of its encoded protein SMARCA4 (BRG1), one of two mutually-exclusive ATPases of the SWI/SNF chromatin remodeling complex. To determine the specificity of SMARCA4 loss for SCCOHT, we examined the expression of SMARCA4 by immunohistochemistry (IHC) in more than 3000 primary gynecologic tumors. Among ovarian tumors, it was only absent in clear cell carcinoma (15 of 360, 4%). In the uterus, it was absent in endometrial stromal sarcomas (4 of 52, 8%) and high-grade endometrioid carcinomas (2 of 338, 1%). Recent studies have shown that SMARCA2 (BRM), the other mutually exclusive ATPase of the SWI/SNF complex, is necessary for survival of tumor cells lacking SMARCA4. Therefore, we examined SMARCA2 expression and discovered that all SMARCA4-negative SCCOHTs also lacked SMARCA2 protein by IHC, including the SCCOHT cell lines BIN67 and SCCOHT1. Among ovarian tumors, the SMARCA4/SMARCA2 dual loss phenotype appears completely specific for SCCOHT. SMARCA2 loss was not due to mutation but rather from an absence of mRNA expression, which was restored by treatment with the histone deacetylase (HDAC) inhibitor trichostatin A. Treatment with HDAC inhibitors or re-expression of either SMARCA4 or SMARCA2 potently inhibited the growth of BIN67 and SCCOHT1 cell lines. Our results indicate that SMARCA4 loss, either alone or with SMARCA2 loss, is the first highly sensitive and specific diagnostic immunohistochemical marker of SCCOHT, and that HDAC inhibitors are promising agents to explore for the treatment of SCCOHT. Citation Format: Anthony N. Karnezis, Yemin Wang, Pilar Ramos, William Hendricks, Holly Yin, Esther Oliva, Emanuela D'Angelo, Jaime Prat, Marisa R. Nucci, Torsten O. Nielsen, Bernard E. Weissman, Jeffrey M. Trent, C Blake Gilks, David G. Huntsman. Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcemic type. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A33.
Resistance to Marek's Disease. Effect of Corynebacterium parvum and Marek's Tumor Cell Vaccines on Tumorigenesis in Chickens 2
Authors: John Donahoe, Stanley Kleven, Caswell Edison
Journal: JNCI Journal of the National Cancer Institute (1978)

A study of nonspecific stimulation of the avian immune system with Corynebacterium parvum and specific stimulation with Marek's tumor cell vaccines revealed that nonspecifically stimulated outbred White Leghorn-type cockerels had higher incidences of tumors than did controls. A study of tumor cell cytotoxicity of sera from Marek's disease virus-exposed birds indicated that humoral factors may play some role in tumor resistance.
Training psychiatrists in the community: a report of the Italian experience
Authors: L Burti, L Mosher
Journal: American Journal of Psychiatry (1986)

In 1978 a revolutionary mental health act was passed in Italy. By closing large mental hospitals and replacing them with community programs, it required a radical shift in psychiatric practice. The authors discuss the background philosophy, principles, and practical implications of this change. They describe a model program and training design of a 4-year residency in which psychiatrists learn the skills for community work while actually working in the community. The residency differs from most U.S. residencies in having trainees responsible for patients wherever they are being treated (residents are not rotated between services), its strong team orientation, and the value placed on community work.
Rational Design of Prevascularized Large 3D Tissue Constructs Using Computational Simulations and Biofabrication of Geometrically Controlled Microvessels
Authors: Chiara Arrigoni, Matilde Bongio, Giuseppe Talò, Simone Bersini, Junko Enomoto, Junji Fukuda, Matteo Moretti
Journal: Advanced Healthcare Materials (2016)

A major challenge in the development of clinically relevant 3D tissue constructs is the formation of vascular networks for oxygenation, nutrient supply, and waste removal. To this end, this study implements a multimodal approach for the promotion of vessel‐like structures formation in stiff fibrin hydrogels. Computational simulations have been performed to identify the easiest microchanneled configuration assuring normoxic conditions throughout thick cylindrical hydrogels (8 mm height, 6 mm ∅), showing that in our configuration a minimum of three microchannels (600 μm ∅), placed in a non‐planar disposition, is required. Using small hydrogel bricks with oxygen distribution equal to the microchanneled configuration, this study demonstrates that among different culture conditions, co‐culture of mesenchymal and endothelial cells supplemented with ANG‐1 and VEGF leads to the most developed vascular network. Microchanneled hydrogels have been then cultured in the same conditions both statically and in a bioreactor for 7 d. Unexpectedly, the combination between shear forces and normoxic conditions is unable to promote microvascular networks formation in three‐channeled hydrogels. Differently, application of either shear forces or normoxic conditions alone results in microvessels outgrowth. These results suggest that to induce angiogenesis in engineered constructs, complex interactions between several biochemical and biophysical parameters have to be modulated.
Platelet Transfusion Practices Among Very-Low-Birth-Weight Infants
Authors: Katherine A. Sparger, Susan F. Assmann, Suzanne Granger, Abigail Winston, Robert D. Christensen, John A. Widness, Cassandra Josephson, Sean R. Stowell, Matthew Saxonhouse, Martha Sola-Visner
Journal: JAMA Pediatrics (2016)

Thrombocytopenia and intraventricular hemorrhage (IVH) are common among very-low-birth-weight (VLBW) infants. Survey results suggest that US neonatologists frequently administer platelet transfusions to VLBW infants with mild to moderate thrombocytopenia.To characterize platelet transfusion practices in US neonatal intensive care units (NICUs), to determine whether severity of illness influences platelet transfusion decisions, and to examine the association between platelet count (PCT) and the risk for IVH in the first 7 days of life.This multicenter, retrospective cohort study included 972 VLBW infants treated in 6 US NICUs, with admission dates from January 1, 2006, to December 31, 2007. Data were collected from all infants until NICU discharge or death (last day of data collected, December 4, 2008). Data were entered into the central database, cleaned, and analyzed from May 1, 2009, to February 11, 2016.Platelet transfusion.Number of platelet transfusions and incidence of IVH.Among the 972 VLBW infants (520 [53.5%] male; mean [SD] gestational age, 28.2 [2.9] weeks), 231 received 1002 platelet transfusions (mean [SD], 4.3 [6.0] per infant; range, 1-63 per infant). The pretransfusion PCT was at least 50 000/μL for 653 of 998 transfusions (65.4%) with this information. Two hundred eighty-one transfusions (28.0%) were given during the first 7 days of life. During that period, platelet transfusions were given on 35 of 53 days (66.0%) when the patient had a PCT less than 50 000/μL and on 203 of 436 days (46.6%) when the patient had a PCT of 50 000/μL to 99 000/μL. At least 1 marker of severe illness was present on 198 of 212 patient-days (93.4%) with thrombocytopenia (PCT, <100 000/μL) when a platelet transfusion was given compared with 113 of 190 patient-days (59.5%) with thrombocytopenia when no platelet transfusion was given. Thrombocytopenia was a risk factor for intraventricular hemorrhage during the first 7 days of life (hazard ratio, 2.17; 95% CI, 1.53-3.08; P < .001). However, no correlation was found between severity of thrombocytopenia and risk for IVH. After controlling for significant clinical factors and thrombocytopenia, platelet transfusions did not have a significant effect on the incidence of IVH (hazard ratio, 0.92; 95% CI, 0.49-1.73; P = .80).A large proportion of platelet transfusions were given to VLBW infants with PCT greater than 50 000/μL. Severity of illness influenced transfusion decisions. However, the severity of thrombocytopenia did not correlate with the risk for IVH, and platelet transfusions did not reduce this risk.
Association between patient reported outcomes and vibratory perception threshold test for measuring neurotoxicity in patients with chemotherapy induced peripheral neuropathy
Authors: G. Lunardi, R. Magarotto, A. Inno, P. Cassandrini, M. Cirillo, S. Duranti, M. Nicodemo, V. Picece, M. Turazza, F. Marchetti, B. Micheloni, M. Valerio, L. Zenari, S. Gori
Journal: Annals of Oncology (2015)
Allergic Pulmonary Aspergillosis
Authors: A W FRANKLAND, E D HAMILTON
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Desipramine for the treatment of "pure" dysthymia versus "double" depression
Authors: D B Marin, J H Kocsis, A J Frances, M Parides
Journal: American Journal of Psychiatry (1994)

The authors report results of an 8-week, open trial of desipramine in 42 patients with DSM-III-R dysthymia with a concurrent diagnosis of major depression ("double" depression) and 33 patients with dysthymia who had no other depressive diagnosis ("pure" dysthymia). Either complete or partial remission was achieved by 70% of the patients with "pure" dysthymia. This compared favorably with but was not significantly different from results in the "double" depression group.
Meningococcal disease in healthcare workers
Authors: C. Trujillo
Journal: BMJ (2000)

# Vaccine is available in Latin America {#article-title-2} EDITOR—I read with interest the editorial by Pollard and Begg.1 For eight years, a vaccine for serogroup meningococcus B has been available in Latin America. This vaccine is produced in Cuba, and, although it may not be perfect, it has shown immunogenicity. The statement that there is no vaccine is incorrect. I would like to know whether Pollard and Begg are aware of this but think it is not a recommended vaccine, or if they are not aware of it. 1. 1.↵1. Pollard AJ, 2. Begg N . Meningococcal disease and healthcare workers. BMJ 1999; 319: 1147–1148. (30 October.) [OpenUrl][1][FREE Full Text][2] # Prophylaxis is not necessary {#article-title-4} EDITOR—Traditionally, Monday mornings are depressing times for medical microbiologists. Until now, this has largely been a result of the handful of new cases of methicillin resistant Staphylococcus aureus discovered over the preceding weekend. In November, however, my usual gloom was turned to despair by a flurry of telephone calls from colleagues in various states of panic demanding prophylaxis for meningococcal disease. I am a consultant microbiologist and infection control doctor, and it has taken me a long time to convince healthcare workers at my trust that antimeningococcal prophylaxis is not necessary for healthcare workers, including ambulance crews, after nursing a patient with meningococcal disease. The only exception to this rule is after mouth to mouth resuscitation. Pollard and Begg in their editorial are advising that antibiotics should be offered to healthcare workers with direct exposure to potentially infected secretions, despite their own assertions that few published reports exist of healthcare workers or laboratory staff developing invasive meningococcal disease.1 This advice seems to be based on a single case of a paediatrician in France, who developed meningococcaemia after intubating a child with meningococcal disease.2 I do not know whether or not a causal link was proved in this case. Such advice is contrary to national guidance.3 Furthermore, the risks of antibiotic chemoprophylaxis are not adequately covered in … [1]: {openurl}?query=rft.jtitle%253DBMJ%26rft.stitle%253DBMJ%26rft.issn%253D0007-1447%26rft.aulast%253DPollard%26rft.auinit1%253DA.%2BJ%26rft.volume%253D319%26rft.issue%253D7218%26rft.spage%253D1147%26rft.epage%253D1148%26rft.atitle%253DMeningococcal%2Bdisease%2Band%2Bhealthcare%2Bworkers%26rft_id%253Dinfo%253Apmid%252F10541486%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=FULL&journalCode=bmj&resid=319/7218/1147&atom=%2Fbmj%2F320%2F7229%2F247.atom
Diagnosis and treatment of mixed mania
Authors: S K Secunda, A Swann, M M Katz, S H Koslow, J Croughan, S Chang
Journal: American Journal of Psychiatry (1987)

In a study of 19 manic patients, the authors found that eight suffered from mixed mania, a condition in which depressive symptoms are found in the context of classic manic features. The presence of a mixed manic state predicted at least a slower and possibly a poor response to lithium therapy. The authors suggest that the delineation of a subgroup of mixed manic patients might help to identify potential lithium-resistant patients.
Updated Clinical Practice Guidelines on Heart Failure: An International Alignment
Authors: Elliott M. Antman, Jeroen Bax, Richard A. Chazal, Mark A. Creager, Gerasimos Filippatos, Jonathan L. Halperin, Steven Houser, JoAnn Lindenfeld, Fausto J. Pinto, Panos Vardas, Mary Norine Walsh, Kim A. Williams, Jose L. Zamorano
Journal: Circulation (2016)
Parkinsonian side effects induced by a monoamine oxidase inhibitor
Authors: J P Teusink, G S Alexopoulos, C A Shamoian
Journal: American Journal of Psychiatry (1984)

A 75-year-old depressed woman treated with the monoamine oxidase inhibitor (MAOI) phenelzine developed a parkinsonian syndrome that remitted after discontinuation of the drug. The authors discuss possible explanations for this unusual phenomenon.
Chronic Hypertension in Pregnancy
Authors: J C Livingston, B D Maxwell, B M Sibai
Journal: New England Journal of Medicine (2011)

Hypertension is the most common medical disorder during pregnancy. Chronic hypertension is a serious medical complication in pregnancy with increased maternal and perinatal morbidity and mortality. Those who develop uncontrolled severe hypertension, those with target organ damage, and those who are poorly compliant with prenatal visits are at high risk for poor perinatal outcome. Maternal complications include abruptio placenta, stroke, and superimposed pre-eclampsia. Fetal complications include prematurity, low birth weight, and perinatal death. Careful antepartum, intrapartum and postpartum management of women with high-risk chronic hypertension in pregnancies may reduce morbidity and mortality.
Junior doctors will have a month to look at details of new contract
Authors: Abi Rimmer
Journal: BMJ (2016)

Junior doctors in England will have just over a month to examine details of their new contract before voting on whether to accept it, as part of an agreement reached between the BMA and the UK government.

On 18 May the arbitration body Acas (the Advisory, Conciliation and Arbitration Service), which facilitated talks between the BMA and the government, announced that an agreement on …
Abstract B07: Long noncoding RNAs underlying genetic predispositions to prostate cancer
Authors: Haiyang Guo, Musaddeque Ahmed, Junjie Tony Hua, Yi Liang, Housheng Hansen He
Journal: Cancer Research (2016)

Abstract Trait-associated SNPs identified through Genome-Wide Association Studies are enriched in regulatory regions. However, the functional link between these SNPs and their target genes remains elusive. Due to their involvement in fundamental biological processes, long noncoding RNAs (lncRNAs) represent an attractive class of molecules mediating cancer risk. Through integrative analysis of the lncRNA transcriptome with genomic and prostate cancer risk SNP data, we identified 60 candidate lncRNAs associated with risk to prostate cancer. The mechanism underlying the top hit, PCAT1, was evaluated further. The risk variant at rs7463708 decreases HOXB13 and increases AR binding at a distal enhancer that loops to PCAT1 promoter, resulting in upregulation of PCAT1 upon prolonged androgen treatment. In addition, PCAT1 interacts with AR and LSD1 and is required for their recruitment to the enhancers of GNMT and DHCR24, two androgen late response genes implicated in prostate cancer development and progression. These findings suggest that modulating lncRNA expression is an important mechanism for risk SNPs in promoting prostate transformation. Note: This abstract was not presented at the conference. Citation Format: Haiyang Guo, Musaddeque Ahmed, Junjie Tony Hua, Yi Liang, Housheng Hansen He. Long noncoding RNAs underlying genetic predispositions to prostate cancer. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr B07.
Pleural tuberculosis: A retrospective study in the tuberculous control unit of Blida between 2005 and 2009
Authors: Lotfi Nacef, Omar Saighi
Journal: European Respiratory Journal (2011)

Introduction: Pleural tuberculosis is among the most common sites of extrapulmonary tuberculosis, which represent 30% of all tuberculosis cases in Algeria. She reached preferentially the young adults.

Aims and objectives: The aim of our study is to clarify the characteristics of the epidemiology, diagnosis, treatements and outcome of pleural tuberculosis and also to clarify the predisposing factors.

Methods: Our retrospective study concerned 117 cases of tuberculous pleurisy supported for 05 years from 2005 to 2009 among a total of 764 cases followed for extrapulmonary tuberculosis at the Blida tuberculous control unit.

Results: Our study has assembled 67 men and 50 women with a mean age of 30 years. Comorbidities in number of 7 are represented by 4 cases of metabolic syndrome. The impairment is most often right sided in 57.2% of cases, and bilateral in 11% of cases. The investigations carried out showed a tuberculin allergy in 31.6% of cases. The histology diagnosis was mainly contributing in 42.7% of cases by finding caseofollicular tuberculous, and in 23.9% of cases by a tuberculoid inflammation. The antibiotic treatment was started in all cases with a favorable outcome to the healing in 50.4% of cases and with sequelae in 45.2% of cases. However, we noted 4 cases of lost sight and one patient transferred for therapeutic monitoring.

Conclusion: The management of tuberculous pleurisy is correlated by the improvement of diagnostic methods, certainty including pleural biopsy and thoracoscopy.
The forgotten group at risk for breast cancer.
Authors: V C Jordan
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.8.1445 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2380764 The forgotten group at risk for breast cancer. V C JordanxV C JordanSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.8.1445 PDF "The forgotten group at risk for breast cancer.." Journal of Clinical Oncology, 8(8), pp. 1445–1446© 1990 by American Society of Clinical Oncology
Proteomic analysis of ascending colon biopsies from a paediatric inflammatory bowel disease inception cohort identifies protein biomarkers that differentiate Crohn's disease from UC
Authors: Amanda E Starr, Shelley A Deeke, Zhibin Ning, Cheng-Kang Chiang, Xu Zhang, Walid Mottawea, Ruth Singleton, Eric I Benchimol, Ming Wen, David R Mack, Alain Stintzi, Daniel Figeys
Journal: Gut (2016)

<h3>Objective</h3> Accurate differentiation between Crohn9s disease (CD) and UC is important to ensure early and appropriate therapeutic intervention. We sought to identify proteins that enable differentiation between CD and UC in children with new onset IBD. <h3>Design</h3> Mucosal biopsies were obtained from children undergoing baseline diagnostic endoscopy prior to therapeutic interventions. Using a super-stable isotope labeling with amino acids in cell culture (SILAC)-based approach, the proteomes of 99 paediatric control and biopsies of patients with CD and UC were compared. Multivariate analysis of a subset of these (n=50) was applied to identify novel biomarkers, which were validated in a second subset (n=49). <h3>Results</h3> In the discovery cohort, a panel of five proteins was sufficient to distinguish control from IBD-affected tissue biopsies with an AUC of 1.0 (95% CI 0.99 to 1.0); a second panel of 12 proteins segregated inflamed CD from UC within an AUC of 0.95 (95% CI 0.86 to 1.0). Application of the two panels to the validation cohort resulted in accurate classification of 95.9% (IBD from control) and 80% (CD from UC) of patients. 116 proteins were identified to have correlation with the severity of disease, four of which were components of the two panels, including visfatin and metallothionein-2. <h3>Conclusions</h3> This study has identified two panels of candidate biomarkers for the diagnosis of IBD and the differentiation of IBD subtypes to guide appropriate therapeutic interventions in paediatric patients.