tbuckley/cabot-search huggingface dataset:
TWO CASES OF RECOVERY AFTER OPERATION FOR DIFFUSE PERITONITIS FROM PERFORATION OF THE APPENDIX
Authors: C. A. Morton
Journal: BMJ (1902)

Seven weeks before admission an abscess lhad formed in the abdominal wall,a1ad hidburst by three openings, tlhrough which faeces had been constantly dischiarged.The abdomen was opened, and a growth, about 5 inches long, was found invading the transverse colon.Fortunately there wbre no adhesions except to the andominal wall, where the bowel *had given way on the proximal side of the obstruction.The growth was prolapsed through the abdominal incision, and fixed there.Four days -later the whole growth was cut away, a Paul's tube being tied Into tlle colon.The patient did well, but of course all the faeces passed thlroughi the opening in the transverse colon, and, as thley were liquid, produced a considerable amount of excoriation.On January 24th, Igot, the patient was again put under an anaesthetic, the abdomen opened in the middle line below the umbilicus, and an ileo-sigmoidostomy performed. ,He passed a motion naturally for the first time on January 3oth, and from that date the greater part of the motions were passed by tlle rectum, but a considerable aimount still passed by tlle colotomy wound.In order to close this the abdomen was reopeued on February 7th, and the ilcum between the anastomosis and the caecum was completely divided, the two ends being invaginated upon themselve3 and closed with sutures.After this operationr the colotomy wound quickly contracted, niothing but a little mucus occasionally escaped.The patient regained health and weight.and returned to work.: When seen at the end of October, Igor, his -general condition was perfect.CASX v.-A female, aged 79, whom I saw with Dr. A. R Fegan, of Black- heath had suffered with some difficulty witlh the bowels and abdominal pain for about six months.Duting the later few weeks she had one or two attacks of almost complete obstruction, which, however, had been * Read before the Bath and Bristol Branclh of tlhe British Medica) Association.
Diabetes and the Kidney
Authors: S. Parmet
Journal: JAMA (2003)

Diabetes and the Kidney Diabetes mellitus is a disease in which the body either fails to produce enough insulin or is unable to use insulin properly.Insulin is a hormone that is needed to convert sugar, starches, and other food into energy used for daily life.If there is not enough insulin, blood glucose (sugar) levels can become high.High levels of glucose in the bloodstream for long periods can damage a number of body organs and systems, including the kidneys.The June 25, 2003, issue of JAMA includes an article about kidney complications in patients with diabetes.
REGENERATION OF PERIPHERAL NERVES.
Authors: A M DOGLIOTTI, L SOLERIO
Journal: JAMA (1905)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Varenicline, combination NRT, and nicotine patch did not differ for smoking cessation at 6 mo
Authors: Brian A. Primack
Journal: Annals of Internal Medicine (2016)

Source Citation Baker TB, Piper ME, Stein JH, et al. Effects of nicotine patch vs varenicline vs combination nicotine replacement therapy on smoking cessation at 26 weeks: a randomized clinical trial. JAMA. 2016;315:371-9. 26813210
Wells Rule and<scp>d</scp>-Dimer Testing to Rule Out Pulmonary Embolism
Authors: Nick van Es, Tom van der Hulle, Josien van Es, Paul L. den Exter, Renée A. Douma, Robbert J. Goekoop, Inge C.M. Mos, Javier Galipienzo, Pieter W. Kamphuisen, Menno V. Huisman, Frederikus A. Klok, Harry R. Büller, Patrick M. Bossuyt
Journal: Annals of Internal Medicine (2016)

Background: The performance of different diagnostic strategies for pulmonary embolism (PE) in patient subgroups is unclear. Purpose: To evaluate and compare the efficiency and safety of the Wells rule with fixed or age-adjusted d-dimer testing overall and in inpatients and persons with cancer, chronic obstructive pulmonary disease, previous venous thromboembolism, delayed presentation, and age 75 years or older. Data Sources: MEDLINE and EMBASE from 1 January 1988 to 13 February 2016. Study Selection: 6 prospective studies in which the diagnostic management of PE was guided by the dichotomized Wells rule and quantitative d-dimer testing. Data Extraction: Individual data of 7268 patients; risk of bias assessed by 2 investigators with the QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies 2) tool. Data Synthesis: The proportion of patients in whom imaging could be withheld based on a "PE-unlikely" Wells score and a negative d-dimer test result (efficiency) was estimated using fixed (≤500 µg/L) and age-adjusted (age × 10 µg/L in patients aged >50 years) d-dimer thresholds; their 3-month incidence of symptomatic venous thromboembolism (failure rate) was also estimated. Overall, efficiency increased from 28% to 33% when the age-adjusted (instead of the fixed) d-dimer threshold was applied. This increase was more prominent in elderly patients (12%) but less so in inpatients (2.6%). The failure rate of age-adjusted d-dimer testing was less than 3% in all examined subgroups. Limitation: Post hoc analysis, between-study differences in patient characteristics, use of various d-dimer assays, and limited statistical power to assess failure rate. Conclusion: Age-adjusted d-dimer testing is associated with a 5% absolute increase in the proportion of patients with suspected PE in whom imaging can be safely withheld compared with fixed d-dimer testing. This strategy seems safe across different high-risk subgroups, but its efficiency varies. Primary Funding Source: None.
Massachusetts Medical Society
Authors: Fred S. Rosen
Journal: New England Journal of Medicine (1960)

FREDERIC HAGLER, M.D.Frederic Hagler died on May 13, 1960, of an acute coronary mishap. Despite a similar seizure several years ago, he had carried on a general surgical practice with zeal, and at only a slightly slower pace, until his retirement in 1957. He was a thoughtful surgeon, conservative but open-minded withal, ever taking time to study and evaluate new ways and methods of the times before adopting them. Trusted and respected alike by his patients and his confreres, he won rightful place among the acknowledged leaders of the profession in his community. He was soft-spoken but steadfast, and . . .
Abstract P6-03-03: The Q-CROC-3 project reveals novel genomic alterations in triple negative breast cancers in residual tumors after neoadjuvant chemotherapy
Authors: M Basik, A Aguilar-Mahecha, J Lafleur, E Bareke, E Przybytkowski, N Alirezaie, F Discepola, S Légaré, B Kovacina, C Lan, CL Mihalcioiu, A Robidoux, E Marcus, J-A Roy, M Pelmus, O Aleynikova, S Nabavi, P Tonellato, J Majewski
Journal: Cancer Research (2016)

Abstract The prognosis of triple negative breast cancer that shows resistance and/or incomplete response to cytotoxic chemotherapy is poor. In order to understand the mechanisms of resistance to chemotherapy and the genomic evolution of TNBCs treated with chemotherapy, an international multi-center biopsy-driven clinical trial was created for the collection and study of drug-resistant primary and metastatic freshly frozen tumors (Q-CROC-03: NCT01276899). We consented 60 patients with operable TNBC undergoing neoadjuvant Anthracycline/Taxane-based chemotherapy for pre and post-treatment biopsies as well as collection of residual tumor at the time of surgery and serial blood sampling. In 12-15 patients, adequate residual tumor material was available for genomic studies, which included whole exome sequencing, array CGH, gene expression microarray profiling and RNAseq of paired tumors. Whole exome sequencing revealed clonal shifts as well as the relatively infrequent appearance of novel mutations in individual tumors, without any recurrently detected variants. Array CGH revealed a remarkable stability in the number of DNA copy number alterations with a few functional alterations enriched for in the residual tumor, including an amplicon involving the NFIB gene. Finally, gene expression profiling showed shifts towards the immune-modulatory and basal TNBC subtypes after chemotherapy as well as an increase in the expression of several targetable genes, including DUSP1, a dual specificity phosphatase. In the 4 cases of primary and matching metastatic tumors, the post-NAC residual tumor had acquired changes many of which persisted in the metastatic sites, indicating that the analysis of the residual tumors can provide a partial picture of genomic changes present in metastases but not in the primary tumor. In summary, the genomic characterization of residual post-NAC tumor tissue provides important information for the development of novel therapeutic strategies for drug-resistant TNBCs as well as a portrait of genomic evolution of TNBCs subjected to chemotherapy. Citation Format: Basik M, Aguilar-Mahecha A, Lafleur J, Bareke E, Przybytkowski E, Alirezaie N, Discepola F, Légaré S, Kovacina B, Lan C, Mihalcioiu CL, Robidoux A, Marcus E, Roy J-A, Pelmus M, Aleynikova O, Nabavi S, Tonellato P, Majewski J. The Q-CROC-3 project reveals novel genomic alterations in triple negative breast cancers in residual tumors after neoadjuvant chemotherapy. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-03-03.
A study of transsexuals seeking gender reassignment
Authors: J C Finney, J M Brandsma, M Tondow, G Lemaistre
Journal: American Journal of Psychiatry (1975)

The authors report the results. of a computerized psychodiagnostic assessment of 19 males and 1 female seeking sex-reassignment surgery. The most pervasive finding was hysterical personality trend (13 of 20 cases). Twelve patients exhibited psychotic trends: 6 showed psychotic thinking on test scores, and 6 received computer-preferred diagnoses of paranoid or schizoid personality. However, most of these 12 patients were not considered psychotic on interview, and those who had sex-reassignment surgery had good results
Psychological factors in susceptibility to drug-induced extrapyramidal symptoms
Authors: P Levinson, R Malen, G Hogben, H Smith
Journal: American Journal of Psychiatry (1978)

In an effort to identify nonneurobiologic factors in the susceptibility to neuroleptic-induced extrapyramidal symptoms (EPS), the EPS response in 20 patients was correlated with field dependence, self-object differentiation, and premorbid social competence. Only the last proved to be a good predictor, which suggests that psychosocial factors play a role in a patient's EPS response.
Sustained virologic response to interferon-free therapies ameliorates HCV-induced portal hypertension
Authors: Mattias Mandorfer, Karin Kozbial, Philipp Schwabl, Clarissa Freissmuth, Rémy Schwarzer, Rafael Stern, David Chromy, Albert Friedrich Stättermayer, Thomas Reiberger, Sandra Beinhardt, Wolfgang Sieghart, Michael Trauner, Harald Hofer, Arnulf Ferlitsch, Peter Ferenci, Markus Peck-Radosavljevic
Journal: Journal of Hepatology (2016)
Required educational objectives in community psychiatry
Authors: J H Shore, J D Kinzie, J D Bloom
Journal: American Journal of Psychiatry (1979)

Community psychiatry is an essential requirement of approved residency training. The authors present a format of required educational objectives for this experience. They feel that recent attempts to limit psychiatric consultation to the consultation-liaison model are restrictive and incomplete. In their view of the psychiatrist's role, community consultation techniques are essential skills for the psychiatric practitioner.
Evaluation of new drugs in untreated patients with small-cell lung cancer: its time has come.
Authors: D S Ettinger
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.3.374 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2155306 Evaluation of new drugs in untreated patients with small-cell lung cancer: its time has come. D S EttingerxD S EttingerSearch for articles by this author Show More Johns Hopkins Oncology Center, Baltimore, MD. https://doi.org/10.1200/JCO.1990.8.3.374 First Page PDF © 1990 by American Society of Clinical Oncology
High users of outpatient mental health services, I: Definition and characteristics
Authors: C A Taube, H H Goldman, B J Burns, L G Kessler
Journal: American Journal of Psychiatry (1988)

Mental health coverage generally limits benefits for high use, which is assumed to be discretionary. The authors present data from the National Medical Care Utilization and Expenditure Survey. Of the individuals who made mental health outpatient visits in 1980, 9.4% made 25 or more visits and accounted for 50% of mental health visits and expenditures. These high users were compared with low users and with high users of other health care. One-third of the mental health high users were highly disabled and had multiple medical disorders. The authors point out the heterogeneity of this population and suggest that psychiatric benefits be differentiated according to patients' needs and services offered.
Second tumors after radiation treatment of testicular germ cell tumors.
Authors: R T Oliver
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.11.2286 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8229145 Second tumors after radiation treatment of testicular germ cell tumors. R T OliverxR T OliverSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.11.2286 PDF "Second tumors after radiation treatment of testicular germ cell tumors.." Journal of Clinical Oncology, 11(11), pp. 2286–2287© 1993 by American Society of Clinical Oncology
Treating Childhood Leukemia without Cranial Irradiation
Authors: Harris V Naina, Samar Harris, Mrinal M Patnaik
Journal: New England Journal of Medicine (2009)

To the Editor: Pui and colleagues (June 25 issue)1 report a high likelihood of event-free and overall survival among children with acute lymphoblastic leukemia (ALL) treated with an intensive regimen of intrathecal chemotherapy and systemic drugs that penetrate the central nervous system (CNS). Their goal was to eliminate cranial irradiation and its late toxic effects. Most other trials of treatment for childhood ALL already treat the majority of patients (80% or more) without cranial irradiation, with similarly favorable results. Indeed, only 14% of patients in the study reported on by Pui et al. would have received cranial irradiation in previous trials. In these patients, survival did not appear to be adversely affected by the elimination of irradiation. Although the overall outcome of this trial was favorable, some subgroups of patients remained at high risk for relapse. Also, the acute systemic and CNS toxic effects of the treatment were not insubstantial, and the long-term neurocognitive outcomes are unknown. Before this investigational approach can be considered the standard of care, its consequences should be more thoroughly evaluated, ideally in randomized trials with larger numbers of patients and longer follow-up. Stephen E. Sallan, M.D.
Abstract CS1-3: Contemporary role of radiotherapy in axillary management
Authors: R Jagsi
Journal: Cancer Research (2016)

Abstract Sentinel lymph node evaluation is an innovation that has radically transformed the surgical approach to the axilla in many patients with breast cancer. This revolution in surgical management has important implications for the optimal use of radiotherapy. The context of decision-making has changed dramatically with the recent maturation of studies that have demonstrated low rates of axillary failure in select patients with clinically negative axillae and 1-2 nodes positive on sentinel node biopsy, even without completion axillary dissection. Optimizing the radiotherapeutic management of the axilla in this modern context requires sophisticated understanding of the characteristics of patients who enrolled on trials such as ACOSOG Z0011 and IBSCG 23-01, including their risk factors and systemic management, as well as the radiation fields actually treated. Many patients treated on these trials received substantial incidental radiation to axillary levels I and II from tangential radiotherapy fields, and some even received directed nodal irradiation, but others did well with little or no radiation at all to the axilla. Understanding how to apply the results of these trials to guide current practice requires the radiation oncologist to integrate the insights of these studies with those from other recent studies evaluating the role of more comprehensive regional nodal radiotherapy that included the supraclavicular and internal mammary regions. Recognizing how the patient populations treated on the NCIC MA20 and EORTC 22922 trials may have differed from those on ACOSOG Z0011 and IBSCG 23-01 is necessary to help reconcile the findings of these studies and guide us in optimizing our patients' radiotherapeutic management decisions. In addition, the landmark AMAROS study, in which patients with clinically negative axillae were randomized to axillary dissection versus axillary radiation after a positive sentinel node biopsy, adds to a long history of clinical trials evaluating the question of optimal axillary management. These studies must be considered in detail in order to determine how best to individualize the use of radiation therapy to maximize disease control and minimize treatment-related morbidity. These issues will be the focus of this clinical science symposium lecture, which will provide a radiation oncologist's perspective on regional nodal management for patients diagnosed with invasive breast cancer, with a specific focus on the axilla. Citation Format: Jagsi R. Contemporary role of radiotherapy in axillary management. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr CS1-3.
Successful graft-versus-host disease prevention without graft failure in 32 HLA-identical allogeneic bone marrow transplantations with marrow depleted of T cells by monoclonal antibodies and complement
Authors: P Herve, JY Cahn, M Flesch, E Plouvier, E Racadot, A Noir, Y Couteret, G Goldstein, A Bernard, R Lenys
Journal: Blood (1987)
The medical student's perspective of psychiatry residency selection procedures
Authors: M H Sacks, S Karasu, A M Cooper, R D Kaplan
Journal: American Journal of Psychiatry (1983)

To determine what factors influence medical students' perception of the application and selection procedures of psychiatric residency programs, the authors sent a questionnaire to 100 medical students interviewed for the residency program at a major psychiatric facility; 43 returned the forms. There was general concordance between the respondents' perception of the institution's selection criteria and their convictions regarding what those criteria ought to be, with the exception that applicants tended to downgrade the dean's letter. Factors important in the residents' evaluation were the warmth, enthusiasm, and interviewing skills of the faculty and residents. They did not object to psychologically probing interviews if the interviews were skillfully conducted. It was important to them that they met the chairman and program director, and if the applicant was a woman, she wanted to have at least one woman interviewer.
Prevalence of Selected Chronic Digestive Conditions. United States, July-December, 1968.
Authors: R W Wilson
Journal: Annals of Internal Medicine (1974)

This report on chronic digestive conditions is the first of a new series of reports on the prevalence of selected chronic conditions" based on data collected as a part of the Health Interview Survey. Estimates of the prevalence of chronic diseases or impairments have been made from information reported in the Health Interview Survey since its inception in July of 1957. Since that time efforts have been made to improve the quality of the data on the prevalence of chronic conditions. Chronic conditions reported in interviews may be described as those of which the respondent is aware and which he is willing to report to an interviewer. The diagnostic accuracy of reported conditions is dependent on the information the attending physician has passed on to the family or, in the absence of medical attention, on the previous medical experience or education of the family. Prior to 1968 in the Health Interview Survey an attempt was made to obtain data on all chronic conditions that respondents had had during the. 12-month period before the date of the interview; checklists of about 40 to 50 chronic conditions and impairments were used. Beginning in 1968 the procedure was changed, and data were obtained only for chronic conditions within one system of conditions each year (although data on all conditions causing long term limitations of activity, disability days, and physician visits were still obtained). In 1968 respondents were read a list of 25 conditions, the majority of which were digestive conditions (see question 16a, appendix III). A more detailed discussion of basic changes made in 1968 can be found in Vital and Health Statistics, Series 2, Number 48.