tbuckley/cabot-search huggingface dataset:
Clinical significance of minimal residual disease in peripheral blood on day 8 induction in childhood B-precursor acute lymphoblastic leukemia: Report from Children’s Cancer Hospital in Egypt.
Authors: Seham Gohar, Iman Sidhom, Magda Assem, Iman Attia, Dina Yassin, Sherine Salem, Sonya Soliman, Nayera Hamdy, Nesreen Ali, Sarah Youssef, Wafaa Rashed, Amr EL Nashar, Khaled Shaaban
Journal: Journal of Clinical Oncology (2015)

e21008 Background: Minimal residual disease (MRD) in childhood acute lymphoblastic leukemia (ALL) during the early stages of therapy is statistically significant indicator of outcome. Aim: To study the prognostic significance of MRD by flow-cytometry in peripheral blood (PB) on day-8 induction in pediatric B-precursor ALL. Patients and Methods: This study included 140 newly diagnosed pediatric B-precursor ALL patients treated at the Children’s Cancer Hospital-Egypt during the period between mid of March 2010 and end of September 2011. ALL patients received adopted protocol of St. Jude Children’s Research Hospital total study XV for low or standard/high risk ALL. Results: The 3-year relapse-free survival (RFS) and event-free survival (EFS) were 87±3.5% and 82±3.7% respectively. Median follow up was 34.9 months (range 24–42). MRD PB day-8 < 1% was encountered in 78% of patients. Patients with day-8 MRD < 1% had 3-year RFS of 90.6±3.4% compared to 73±10.7% for day-8 MRD ≥ 1% (P =0.042). The prognostic factors which had statistically significant impact on RFS by univariate analysis were patient risk, favorable triple trisomies, and MRD PB day-8. By multivariate analysis, patient risk was the only independent factor affecting RFS. (HR = 6.9; and 95% (CI):1.7-27.8). Day-8 PB MRD had statistical significant association with initial TLC, DNA index, molecular translocations including t(12,21), t(9,22) and risk groups. Patients having favorable double or triple trisomies with MRD PB day-8 < 1% had 3-year RFS of 97±2.7% compared with 74±16% for similar patients having MRD day-8 ≥ 1% (P = 0.028). Conclusions: MRD in PB by flow-cytometry on day-8 induction constitutes an early prognostic index for children with B-Precursor ALL. MRD PB day-8 can help in identification of a subgroup of patients with favorable double or triple trisomies in whom de-escalation of therapy can be considered especially in developing countries to help reducing therapy related morbidity and mortality.
PWE-175 Prevalence of pathological gastroesophageal reflux in patients with severe oesophageal hypomotility who do not present with typical reflux symptoms
Authors: C Premathilaka, G Sui, T Wong, J Jafari
Journal: Gut (2015)

<h3>Introduction</h3> Oesophageal hypomotility (OH) disorders are characterised by a decrease in the vigour of distal oesophageal contractions. An estimated 21 to 49% of patients with pathological gastroesophageal reflux (GOR) also have associated OH. However, prevalence of pathological GOR in OH who do not present with reflux symptoms has not been characterised. Overlooked reflux in these patients may hamper the success in treatment and also increase the risk of long-term side effects from chronic reflux. The aim of this study was to investigate the prevalence of pathological GOR and clinical presentation of patients with severe OH who do not present typical gastroesophageal reflux disease (GORD) symptoms. <h3>Method</h3> All patients diagnosed with frequent failed peristalsis or absent peristalsis on oesophageal high resolution manometry during January 2013 – December 2014 were selected retrospectively. Exclusion criteria were having typical reflux symptoms (heartburn and/or regurgitation) and history of antireflux surgery. All patients underwent ambulatory 24 h reflux monitoring. pH cut off 4 was used and pathological GOR was defined as high acid exposure time (total &gt;6.3%, supine &gt;1.2%, upright &gt;4.2%)<sup>1</sup>and/or high number of reflux events &gt;73. Symptoms were reported by the patient during interview. P value &lt; 0.05 was considered significant. <h3>Results</h3> In total, 78 patients (30 male, 48 female; mean age 55 [19–82]) were included. Pathological GOR was detected in 28/78 (36%) of the patients [abnormal acid exposure time: 12/78 (15%) upright, 11/78 (14%) supine, 12/78 (15%) total, abnormal number of reflux events 15/78 (19%)]. The most common symptoms in patients with pathological GOR: dysphagia 21/28 (75%), chest pain 11/28 (39%) and cough 9/28 (32%) and in patients without GOR: epigastric pain: 19/50 (38%), chest pain 18/50 (36%), dysphagia 16/50 (32%). Epigastric pain was more commonly reported in patients without pathological GOR (P &lt; 0.001). <h3>Conclusion</h3> Pathological GOR is prevalent in one third of the patients with severe OH without typical GORD symptoms. Reflux monitoring maybe indicated in patients with severe OH regardless of their presenting symptoms. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Johnson LF, DeMeester TR. Twenty-four-hour pH monitoring of the distal esophagus. A quantitative measure of gastroesophageal reflux. Am J Gastroenterol. 1974:62:325–332.
George Hall Hogeboom 1913–1956
Authors: W C SCHNEIDER
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article George Hall Hogeboom 1913–1956 Get access Walter C. Schneider Walter C. Schneider Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages III–IX, https://doi.org/10.1093/jnci/17.5.III Published: 01 November 1956
Paranoid disorder: the Soviet viewpoint
Authors: D W Swanson, D K Swanson
Journal: American Journal of Psychiatry (1986)

The Russian-language psychiatric literature on the paranoid disorders was reviewed for a recent 10-year period. The authors were from a variety of facilities and geographic locations. Bibliography references were primarily European, although 41% of the articles included references to American publications. The paranoid patient population was similar to that in the United States. There was extensive longitudinal study of the disorders; epidemiologic investigations, diagnostic classification, pharmacotherapy, treatment outcome, and etiologic theories allowed comparison with these issues in the United States.
Adjuvants for peptide-based cancer vaccines
Authors: Hiep Khong, Willem W. Overwijk
Journal: Journal for ImmunoTherapy of Cancer (2016)

Cancer therapies based on T cells have shown impressive clinical benefit. In particular, immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing dramatic tumor shrinkage and prolonged patient survival in a variety of cancers. However, many patients do not benefit, possibly due to insufficient spontaneous T cell reactivity against their tumors and/or lacking immune cell infiltration to tumor site. Such tumor-specific T cell responses could be induced through anti-cancer vaccination; but despite great success in animal models, only a few of many cancer vaccine trials have demonstrated robust clinical benefit. One reason for this difference may be the use of potent, effective vaccine adjuvants in animal models, vs. the use of safe, but very weak, vaccine adjuvants in clinical trials. As vaccine adjuvants dictate the type and magnitude of the T cell response after vaccination, it is critical to understand how they work to design safe, but also effective, cancer vaccines for clinical use. Here we discuss current insights into the mechanism of action and practical application of vaccine adjuvants, with a focus on peptide-based cancer vaccines.
Non-bacterial thrombotic endocarditis.
Authors: G Amaral, E H Santos Júnior, L C de Azevedo, L A de Azevedo, J Pimenta
Journal: BMJ (1971)

A case of a 38 year-old female patient admitted to the hospital with stroke is reported. Transesophageal echodoppler cardiogram showed mitral valve prolapse associated with a vegetation on its anterior leaflet, and this vegetation was a possible embolic source. The follow-up without signs of infectious disease, the good clinical outcome and the regression of the valvar vegetation without use of antibiotics consolidated the diagnosis of nonbacterial thrombotic endocarditis. As far as it is known, this is the first reported case with antemortem diagnosis and good outcome with treatment with aspirin and ticlopidine.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1973)

COMMITTEE ON MATERNAL WELFAREDiabetes and Cardiac ArrestA 23-year-old gravida 2, para 1 (by cesarean section), died early in the third trimester after a second cardiac arrest during her third hospital admission. The baby had been delivered six days earlier.Diabetes mellitus, discovered at the age of 10 and requiring large doses of insulin, had initiated a career of frequent hospital admissions, recalcitrant behavior, insulin reactions and episodes of ketoacidosis. Management of the first pregnancy at the age of 19 years had been difficult because of emotional instability, limited intelligence and lack of co-operation, but it was successfully terminated . . .
Study of Effects of Norepinephrine on Microcirculation of Dog Omentum in Oligemic Shock
Authors: W SCHUMER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Canadian Mammography Study To Be Reviewed by Outside Team
Authors: K Smigel
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Canadian Mammography Study To Be Reviewed by Outside Team Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 6, 15 March 1995, Pages 413–414, https://doi.org/10.1093/jnci/87.6.413 Published: 15 March 1995
"Coffee groups": a nine-year follow-up study
Authors: R Masnik, S W Olarte, A Rosen
Journal: American Journal of Psychiatry (1980)

The authors present a 9-year follow-up study of 76 chronically ill psychiatric patients treated in "coffee groups," a maintenance treatment approach first described in a pilot study in 1976. Their findings show a significant drop in rehospitalization rates for chronic schizophrenic patients after they had started to attend the group, despite irregular patterns of participation and attendance. There was a leveling off of measurable change in psychosocial functioning in contrast to earlier optimistic reports. The coffee group formula has proved to be economical and is viable for a wide chronic diagnostic range and for a variety of therapists' styles.
Implicit preadmission screening criteria in an alcoholism treatment program
Authors: M R O'Leary, M L Speltz, D M Donovan, R D Walker
Journal: American Journal of Psychiatry (1979)

The fact that alcoholism programs are biased in terms of the kind of patients admitted to treatment is well recognized. The authors examined the possible bias of preadmission screening procedures in an alcoholism treatment program and investigated some of the criteria used by staff clinicians in determining an applicant's acceptability for treatment. They found that accepted and rejected applicants had highly similar characteristics, differing only in age (accepted applicants were slightly younger than those rejected) and source of referral. The overall findings suggest that clinicians implicitly evaluate problem drinkers along dimensions related to their perceived "treatability" in a given therapeutic setting.
AB0409 Relationship Between Disease Activity and Muscle Wasting in Rheumatoid Arthritis (RA) Patients
Authors: Z. Ozbalkan, K. Sahin, M. Erdugan, S. Masatlioglu, Y. Karaaslan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Not only joint destruction but also muscle wasting due to rheumatoid cachexia has been problem in terms of quality of life with RA. In this case control prospective study we want to show a relation between disease activity and serum creatinin kinase-a marker, which reflects muscle mass-levels in active RA patients. <h3>Methods</h3> Age matched 71 female RA patients as study group and 34 female osteoarthritis patients as control group were included in to the study. Patient9s data including acute phase reactants (erythrocyte sedimentation rate-ESR and C-reactive protein-CRP), rheumatoid factor (RF) and anti-CCP positivity and disease activity scores (DAS28-RA) were collected. Serum creatinin kinase (CK) levels were measured. <h3>Results</h3> RA patients group: DAS28: 5.79±1.29; ESR: 69±31 mm/h; CRP 32.5±40 IU/L; RF: 183±23.1 IU/mL; CCP: 91.5IU/mL. 18 patients were obese (BMI&gt;30) and remaining patients9 BMI&lt;30. 56 patients were using steroids and mean steroid dose was 5.13±2.8 mg/daily. All patients were in at least one disease-modifying antirheumatic drugs (DMARDs) therapy alone or in combination. Mean CK level was 38±25 mg/dL. OA control group: ESR 23±16 mm/h, CRP: 7.3±4.4 IU/L; RF: 18.3±34.8 IU/mL, CCP: 24.0±15.6 IU/L. 16 of controls were obese (BMI&gt;30), the remaining controls were in normal ranges (BMI&lt;30). None of the controls were using steroids. Mean CK level was 73±34mg/dL. “Pearson9s Correlation Analysis” was performed. P&lt;0.05 was accepted as significant. There was a significant difference between the study and control groups about the CK levels (p&lt;0.004). Inverse correlation between DAS 28 and serum CK levels were significant (p&lt;0.001). <h3>Conclusions</h3> Increased activity was accompanied by a decrease in serum creatinin kinase. From 1978 we know that in active RA, urinary creatinin excretion was invariably increased according to the disease activity. Therefore, inflammation could be characterized as double-edge sword, requiring a balance between health as maintained by regular exercise and activities that would exacerbate inflammatory response. In RA patient population exercise is necessary to prevent muscle contractions and mobility. Type of exercise should be well decided and balanced in RA patients. <h3>References</h3> Helliwell PS, Jackson S. Ann Rheum Dis 1994; 53:726-28. Kramer HR, Fontaine KR, Bathon JM. Arthritis Rheum 2012 Aug; 64(8): 2438-50. <h3>Disclosure of Interest</h3> None declared
CSF GABA in normal subjects and patients with depression, schizophrenia, mania, and anorexia nervosa
Authors: R H Gerner, T A Hare
Journal: American Journal of Psychiatry (1981)

The authors examined the CSF GABA of 87 subjects: 29 normal control subjects, 11 patients with schizophrenia, 26 with depression, 6 with mania, and 15 with anorexia nervosa. Depressed patients had significantly lower CSF GABA levels than did normal subjects. This finding suggests that GABA may have a direct or indirect association with depressive affective disorders.
Platelet Monoamine Oxidase Activity in Schizophrenia: A Review of the Data
Authors: Richard Jed Wyatt, Steven G. Potkin, Dennis L. Murphy
Journal: American Journal of Psychiatry (1979)

The authors review studies of platelet and white cell monoamine oxidase (MAO) activity in schizophrenic patients. The data on acute schizophrenic patients remain inconclusive. Review of 26 reports of chronic schizophrenic patients leaves little doubt, however, that there is a subgroup in which the enzyme activity is decreased. Despite the strong association of decreased MAO activity and chronic schizophrenia, the etiological relationship of low platelet MAO activity to schizophrenia has not been demonstrated. More complete diagnostic descriptions will shed light on precisely which patients have lowered MAO activity. Further metabolic investigations with such patients are needed to determine the physiological significance of this phenomenon.
In vivo inhibition of platelet MAO activity by tricyclic antidepressants
Authors: J L Sullivan, C Dackis, C Stanfield
Journal: American Journal of Psychiatry (1977)

Platelet MAO activity decreased by 40% (p less than .001) in a group of 11 male patients with primary depression after 3 weeks of treatment with either amitriptyline or imipramine. This finding, together with data from previous in vitro studies demonstrating tricyclic-induced inhibition of mitochondrial MAO, suggests that inhibition of MAO plays a role in the clinical action of tricyclic antidepressant drugs.
PTU-034 Autofluorescence imaging in post-operative crohn’s disease colonoscopy differentiates disease recurrence from anastomotic ulceration
Authors: B Hayee, P Dubois, A Haji
Journal: Gut (2015)

<h3>Introduction</h3> Colonoscopic assessment after post-operative resection and re-anastomosis for Crohn’s disease (CD) is an accepted part of the routine follow-up of such patients. Anastomotic ulcers (figure) are a relatively frequent observation and may be misinterpreted as recurrent CD, thus incurring the need and cost of biopsy examination. Autofluorescence imaging (AFI) technology detects the wavelengths of light emitted by endogenous molecules (fluorophores; such as NAD, FAD), corresponding to their concentration, metabolic state and spatial distribution<sup>1</sup>. In tissue with a high metabolic rate or under oxidative stress (inflammation or dysplasia), AFI generates a purple colouration, compared to green when normal tissue is imaged. We hypothesised that AFI might discriminate between appearances due to anastomotic ulceration and CD recurrence. <h3>Method</h3> Patients at our Institution undergoing per-protocol colonoscopy as part of routine post-operative evaluation of CD were examined with the AFI colonoscope (Olympus CF-FH260AZL and either 260 or 290 series processor) by three consultant Endoscopists familiar with AFI technology. The Endoscopists’ opinion as to whether the endoscopic appearance was most in keeping with anastomotic ulceration, with mostly fixed purple (AFI+) or green (AFI-) fluorescence was recorded and compared to eventual histology results. As the measurement of faecal calprotectin (FCALP) is also protocolised post-operatively, we were also able to take into account this well-validated marker. <h3>Results</h3> 10 patients were examined with AFI. 4 were AFI+ and all were confirmed as having histologic evidence of IBD. 5 were AFI- and again all were confirmed by histologic examination. 1 patient had equivocal changes on AFI and biopsies excluded recurrent CD. Faecal calprotectin was &lt;100 mcg/g at 3 and 6 months post-operatively 5/6 patients in whom AFI was normal or equivocal, and elevated at 6 months &gt;100 in all 4 patients AFI+. <h3>Conclusion</h3> Although a small cohort, our results indicate that AFI may be highly discriminatory and suggests potential new applications for this technology: combining non-invasive markers and findings on AFI, NBI and magnification might obviate the need for biopsy to exclude disease recurrence; the degree and extent of mucosal inflammation could be assessed; dysplasia could more readily be detected. Further prospective studies are planned to determine and establish the role of AFI in IBD. Use of the 290 series processor with this technology may improve detection and discrimination. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> ASGE technology assessment. Gastrointest Endosc 2011;<b>73</b>:647–50
The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph+ CML
Authors: Irina Sadovnik, Harald Herrmann, Sabine Cerny-Reiterer, Wolfgang Warsch, Andrea Hoelbl, Katharina Blatt, Barbara Peter, Gabriele Stefanzl, Gregor Hoermann, Susanne Herndlhofer, Berthold Streubel, Wolfgang R Sperr, Christine Mannhalter, Veronika Sexl, Peter Valent
Journal: Blood (2013)
Letters
Authors: Robert L. Carolla
Journal: Annals of Internal Medicine (2015)

Letters17 November 2015LettersRobert L. Carolla, MDRobert L. Carolla, MDFrom CoxHealth, Springfield, Missouri.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-5168 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I appreciate Dr. Hartmark-Hill's kind comments about my essay. I am touched that it may be a tool to inspire future physicians. Nearly 40 physicians have taken the time to communicate their comments to me—mostly by e-mail but also with handwritten notes and letters. I have heard from oncologists as well as other subspecialists. All comments have been positive. I am truly stunned by the response. Clearly, the article has struck a chord with many. In a sense, it went viral, Annals style!Of course, our patients desire state-of-the-art care. This is what our training is all about, ... Author, Article, and Disclosure InformationAffiliations: From CoxHealth, Springfield, Missouri.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M14-2884. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoLetters Robert L. Carolla Metrics 17 November 2015Volume 163, Issue 10Page: 806KeywordsDisclosureEmotionsFearForecastingPatient advocacyPatientsSub-specialty care ePublished: 17 November 2015 Issue Published: 17 November 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...