tbuckley/cabot-search huggingface dataset:
SP0079 Pathogenesis of Idiopathic Inflammatory Myopathies
Authors: K. Nagaraju
Journal: Annals of the Rheumatic Diseases (2015)

Idiopathic inflammatory myopathies (IIMs) are a heterogenous group of complex muscle diseases of unknown cause. These diseases are characterized by muscle inflammation, progressive muscle weakness and damage, together with involvement of other organ systems. Conventionally, adaptive immune mechanisms (cell mediated and humoral) have been implicated in the pathogenesis of inflammatory myopathies. However, recent studies have provided evidence that not only adaptive immune pathways but also innate immune (e.g., TLR-NF-κB) signaling, and non-immune pathways such as endoplasmic reticulum stress response, autophagy, metabolic deficits in ATP generating pathways and hypoxia are involved in the disease pathogenesis. However, the relative contributions of each of these mechanisms to disease pathogenesis are currently unknown. Understanding the relative contributions of each of these pathways to disease pathogenesis would help to identify drugs that target these pathways to improve muscle weakness and quality of life for patients suffering from these debilitating muscle diseases. <h3>Disclosure of Interest</h3> None declared
The Response of Acinetobacter baumannii to Zinc Starvation
Authors: Brittany L. Nairn, Zachery R. Lonergan, Jiefei Wang, Joseph J. Braymer, Yaofang Zhang, M. Wade Calcutt, John P. Lisher, Benjamin A. Gilston, Walter J. Chazin, Valerie de Crécy-Lagard, David P. Giedroc, Eric P. Skaar
Journal: Cell Host & Microbe (2016)
PARE0012 Building Patient Led Organisations – An Example of Hungary
Authors: J. Ortutay, E. Rozán
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Hungarian League organised a very successful campaign for people with rheumatoid arthritis in 2013. The aim of the campaign "Take a paintbrush" was to raise awareness of this severe disease and to help people with rheumatoid arthritis (RA) to get closer to each other and to their health care providers by using the tools of graphic art. In eight cities of Hungary painting together the world9s biggest postcard, which was awarded by the Guinness World Records, resulted in a positive teamwork experience for all participants: people with RA, doctors, nurses, family members, friends and media stars. After this campaign authors decided to make use of it and motivate the participants to build patient organisations in those towns, which did not have any by this time. <h3>Methods</h3> By organising cultural programs and meetings where the good practice was reported – by patients leading clubs and organisations country-wide – and the local problems were discussed, people in four towns decided to form local branches of the Hungarian League. They were supported by the board of the league, and a generous sponsor too. All of them are patient led organisations. <h3>Results</h3> Among the first activities they participated in the World Arthritis Day 2014 campaign in Budapest, where little origami ships with thoughts of RA patients were setting afloat in a fountain with thermal water. Another new member of the Hungarian League is the Association of Rheumatic Patients for Targeted Therapy, founded in 2014. This patient led organisation is collecting people receiving biologics, they support them by education program about this very special therapy, help in self management, overcoming the fairs about side effects, and raising awareness of RA. The Hungarian League utilizes the beneficial effect of the literature to build patient led organisations by organising meetings in several cities to show people example and solution by the help of books written by patients or telling stories about people with chronic diseases (RA). These books with biblio-therapeutic method support them to understand their situation, their needs, to cope with their problems, and if it is possible, to build an own patient led organisation. <h3>Conclusions</h3> The board of the Hungarian League aimed to modify the attitude of its member associations, encouraging them to have more people with arthritis/rheumatism in their board: helps them by educating board members how to set goals and work active for others. This work is supported generously by the EULAR-PARE Standing Committee, the good practice of other European Leagues, the training workshops of the Annual Conference, and the training course of the European Patient Forum. <h3>Disclosure of Interest</h3> None declared
Neuropsychology still needs to model organismic processes “from within”
Authors: Juan Pascual-Leone, Antonio Pascual-Leone, Marie Arsalidou
Journal: Behavioral and Brain Sciences (2015)

Abstract Four issues are discussed: (1) differences between cognition and emotion; (2) affect, emotion, and motivation differentials, including a neuropsychological model of motivation; (3) mental attention (working memory) as a resource neither affective nor cognitive, but applicable to both; and (4) explication of neuropsychological scheme units, which have neuronal circuits as functional infrastructure, thus helping to clarify the semantics of functional connectivity.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1971)

COMMITTEE ON MATERNAL WELFAREPLACENTA PRAEVIA AND ACCRETAA 27-year-old gravida 3 with a contracted pelvis and two previous cesarean sections entered the emergency room at 24 weeks bleeding profusely.Both previous pregnancies had been uneventful, but in the present one, "bleeding off and on throughout" had required admission on the first visit at 21 weeks. After x-ray study showed the placenta in the fundus anteriorly, without excluding marginal implantation, the patient had been discharged in 48 hours.Three weeks later profuse bleeding recurred at 7:30 a.m. She was admitted to the hospital at 10:00 a.m., and the first transfusion . . .
SAT0273 Deaths Associated with Ankylosing Spondylitis in France from 1969 to 2009
Authors: C. Prati, X. Guillot, D. Wendling
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic inflammatory joint disease that can lead to chronic pain in the axial and peripheral joints and to functional impairments. AS is a systemic disease that can cause extraarticular manifestations which could participate to excess mortality. The aim of the study is to describe characteristics of deaths for which AS was mentioned on the death certificate as either the underlying cause or anywhere on the death certificate and to analyze trends in AS related mortality from 1969 to 2009 in France. <h3>Methods</h3> Data were obtained from the Centre of Epidemiology on the Medical Causes of Death (CépiDc) for individuals aged 18 years and over died in France. Owing to implementation of International Classification of Diseases (ICD) 8, ICD-9 and ICD-10 for recording causes of deaths, three separate periods were analyzed (1969-78; 1979–99 and 2000–09). Initial, terminal and associated causes of deaths were analyzed. Initial Causes of deaths were compared with deaths of French general population in the same periods (CIM9 and 10) using Standard Mortality Ratio (SMR) adjusted for age and sex and mortality rate <h3>Results</h3> In the global period (1969-2009), AS appeared in 2942 deaths certificates, 2292 men (mean age of death 68,7 years) and 650 women (mean age of 75,8), 601 between 1969-78 (ICD8), 1471 between 1979-1999 (ICD9) and 867 between 2000 and 2009 (ICD10). While mortality rate decreases in the population since 1979, mortality rate of AS remains stable. The number of deaths with AS on the death certificates is increasing due to change of ICD and increase of diagnosis. AS is mentioned as initial cause in 38% in 1969-1978, 33% in 1979-1999 and 5% in 2000-2009. Apart from AS, most frequent initial causes are diseases of the circulatory system (28,5% in ICD8, 23,1% in ICD9 and 26,5% in ICD10 and neoplasms (7,8%, 10,2% and 16,3%). SMR adjusted for age and sex in recent period (2000-2009) are 2,09 (IC 1,45-2,91) for infections, 1,65 (1,31-2,06) for respiratory diseases, 1,9 (1,57-2,29) for external causes and 0,42 (0,35-0,5) for cancers. <h3>Conclusions</h3> The manner of death coding varies according to ICD. Our study is the first to analyze AS data from deaths certificate in France. There is overmortality from respiratory system, infectious diseases and external cause of death in AS, conversely, AS patients appear to die less frequently of cancer than the general population. <h3>Disclosure of Interest</h3> None declared
FRI0622-HPR What Competencies for Rheumatology Nurses? Results of a Multicentric Survey Among Health Professionals and Nurses in France:
Authors: C. Beauvais, L. Gossec, A. Mulliez, F. Fayet, R.M. Poilverd, S. Pouplin, S. Perrot, C. L'Amour, M. Mezieres, M.P. Aubert, N. Jaccaz Vallée, C. Savel
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> EULAR recommendations aim to promote the role of nurses (RN) in the management of rheumatic conditions (RMD) particularly of inflammatory arthritis (IA). Great differences have been pointed out among European countries regarding the nurses9 activities and qualifications. One barrier to the implementation of recommendations could be the lack of specific training (ref1,2). <h3>Objectives</h3> To obtain a better knowledge of the competencies and educational needs of French nurses through a multicentric survey. <h3>Methods</h3> A multidisciplinary group elaborated a first list of competencies considered useful for RNs. Participants were asked to refer to the EULAR recommendations for RN9s role and RMD management and to the available European educational courses. A validation was made by a larger number of participants leading to a second list as a basis for the survey. The survey was conducted through 3 on-line investigations from Dec 2014 to Jan 2015, dedicated to nurses working the field of rheumatology. The nurses were asked if they believed they had acquired each competency on the list and if they considered it of importance for a RN. <h3>Results</h3> The working group included 17 health professionals (HPs) (11 nurses), 8 rheumatologists, 2 patients. The selected competencies concerned IA, osteoarthritis, osteoporosis, low back pain, pain management. Cognitive skills on disease and treatment, practical skills, communication, patient education, on-going support and research were considered. The validation was made by 39 HPs (20 nurses) and 1 patient association. The 1rst on-line investigation addressed the competencies in IA, the 2nd in other RMD, the 3rd in communication, education, continuity of care and research. They included respectively 78, 72, 70 items. Results of the 1rst investigation are presented: 60 nurses responded the survey, from 14/20 French regions, 93% female, 74% in a university hospital; 25% declared complementary qualifications in patient education, 15% in pain management, 8% in research. A gap was found between the competencies considered important and the actual reported skills (table). Nurses were very (45%) or rather (45%) interested by a RN training course. Only 22% believed they could very easily attend the course, 39% rather easily, 33% could not attend. <h3>Conclusions</h3> This study, the first in the field of rheumatology nurse competencies in France, shows a gap between educational needs and reported skills. The survey goes on which results will help in developing a nationwide educational course. <h3>References</h3> van Eijk-Hustings Y, et al. Ann Rheum Dis 2012;71:13-9. van Eijk-Hustings Y, et al. Rheumatology. 2014;53:1491-6. <h3>Disclosure of Interest</h3> None declared
Exercise-induced haemoptysis as a rare presentation of a rare lung disease
Authors: Andrew D Mihalek, Carissa Haney, Maria Merino, Sinchita Roy-Chowdhuri, Joel Moss, Kenneth N Olivier
Journal: Thorax (2016)

Amyloid primarily affecting the lungs is a seldom seen clinical entity. This case discusses the work-up of a patient presenting with exercise-induced haemoptysis and diffuse cystic lung disease on radiographic imaging. The common clinical and radiographic findings of diffuse cystic lung diseases as well as a brief overview of pulmonary amyloid are presented.
Isoniazid Hepatotoxicity
Authors: DANIEL B. GOULD
Journal: Annals of Internal Medicine (1973)

Letters1 December 1973Isoniazid HepatotoxicityDANIEL B. GOULD, M.D., HORACIO FALCAO, M.D., JAMES GALDABINI, M.D.DANIEL B. GOULD, M.D.Search for more papers by this author, HORACIO FALCAO, M.D.Search for more papers by this author, JAMES GALDABINI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-6-902 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: The report on isoniazid hepatitis by Maddrey and Boitnott, in the July issue (Ann Intern Med 79:1-12, 1973), helped us to recognize the same complication in a renal allograft recipient.A 29-year-old man with chronic glomerulonephritis was maintained on hemodialysis for 2 months. He received a cadaveric renal transplant after a nephrectomy on 19 April 1973. The liver and spleen were then impalpable. He was given antithymocyte globulin, prednisone, and azathioprine. Ten days after transplantation the azathioprine dose was reduced to 25 mg daily because of transient leukopenia; the 100-mg dose was reinstituted 1 month later. Isoniazid,...References1. SPARBERG M, SIMON N, and DEL GRECO F: Intrahepatic cholestasis due to azathioprine. Gastroenterology 57:439-441, 1969 CrossrefMedlineGoogle Scholar2. ZARDAY Z, VEITH F, and GLIEDMAN M: Irreversible liver damage after azathioprine. JAMA 222:690-691, 1972 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: DANIEL B. GOULD, M.D.; HORACIO FALCAO, M.D.; JAMES GALDABINI, M.D.Affiliations: Hemodialysis Unit Massachusetts General Hospital Boston, Massachusetts PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFRACTIONATION OF STARCH 1 December 1973Volume 79, Issue 6Page: 902-903KeywordsCadaveric renal transplantationGlobulinsGlomerulonephritisHepatitis AIsoniazidLiverNephrectomySpleenTransplantation ePublished: 1 December 2008 Issue Published: 1 December 1973 PDF downloadLoading ...
China’s One-Child Policy
Authors: Stephen P. Barrows
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Salmonella Enteritidis phage type 21 outbreak in Austria, 2005
Authors: D Schmid, S Schandl, A M Pichler, C. Kornschober, C Berghold, A Beranek, G Neubauer, M Neuhold-Wassermann, W Schwender, A Klauber, A Deutz, P Pless, F Allerberger
Journal: Eurosurveillance (2006)

We report an outbreak of gastroenteritis due to Salmonella Enteritidis PT 21 associated with attending an annual traditional fair in a small Austrian village on 4 May 2005. The outbreak lasted from 4 to 8 May. Descriptive and analytical epidemiological investigations were conducted in order to determine the extent of the outbreak and to identify outbreak risk factors. Of the 115 persons who visited the fair, 85 persons fulfilled the criteria of an outbreak case (attack rate=73.9%). Stool specimens from 52 patients, including two kitchen staff, were tested for salmonella, and 20 specimens were positive for Salmonella Enteritidis PT 21. The cohort study revealed mixed salad (which included potatoes) as the likely cause of the outbreak (RR: 10.4, 95%CI 2.8 - 39.1; P=&lt;0.001). The causative agent of the outbreak was cultured from the stock of eggs used at the fair and from all three drag swabs and one barn dust sample collected from the responsible egg laying flock. Molecular subtyping by pulsed-field gel electrophoresis of genomic DNA after XbaI digestion showed that isolates from eggs, from the flock and from humans were indistinguishable. We hypothesise that cross contamination from eggs to boiled potatoes occurred in the kitchen area, where raw eggs were handled by village residents preparing a traditional Viennese egg dressing. Unrefrigerated storage of peeled potatoes may have favoured bacterial growth. Eggs from small rural flocks of laying hens kept in a traditional 'natural' way should not be assumed to be salmonella-free.
Adjuvant Docetaxel for Node-Positive Breast Cancer
Authors: Manmeet S Ahluwalia, Hamed A Daw
Journal: New England Journal of Medicine (2005)

954 n engl j med 353;9 www.nejm.org september 1, 2005 Despite the consistency of our findings, observational studies are not equivalent to randomized clinical trials, and thus we agree with the conclusion of Maisonneuve and Lowenfels that placebo-controlled trials are required to clarify further the potential relationship between statins and the risk of colorectal cancer. Jenny N. Poynter, Ph.D. Stephen B. Gruber, M.D., Ph.D., M.P.H. University of Michigan Ann Arbor, MI 48109-0638 sgruber@umich.edu Gad Rennert, M.D., Ph.D. Clalit Health Services National Cancer Control Center 34362 Haifa, Israel
Joint custody: solution or illusion?
Authors: E P Benedek, R S Benedek
Journal: American Journal of Psychiatry (1979)

Although the phrase "joint custody" is in popular use, the concept lacks standard definitin; parents who express interest in this form of disposition have widely differing objectives and expectations. The authors discuss the need for determining the primary objectives of the parties involved and for exploring the potential for achieving these through joint custody as well as through other alternatives. They examine the benefits of joint custody as well as the risks engendered by this type of arrangement and make a number of specific recommendations. They conclude that joint custody should be considered and explored, together with other available alternatives, and awarded only in appropriate cases.
SP0216 The Principles of Health Economics
Authors: J. Pink
Journal: Annals of the Rheumatic Diseases (2015)

Health economics is a field that takes the basic ideas of economics: i) scarcity – there are never enough resources to do all the things we would wish to and ii) opportunity cost – whenever we make a decision to invest in a service, we at the same time are also making the decision not to invest in something else, and applies them to health and healthcare. Its ambition is to maximise the benefit that can be gained from the finite resources (people, money, time) that we have available. The lecture will present the basic ideas of health economics (how to measure the value an intervention provides, how to reconcile the different priorities of clinicians, patients and the public, how to priorities resources between very different interventions/areas of health), and show how these can be used to help inform decision making, and evaluate the impact of different possible policy alternative. –How do we measure outcomes in health economics? –How do we measure costs in health economics? –How can health economics help to inform clinical and policy decisions? <h3>Disclosure of Interest</h3> None declared
The war on cancer has a birthday, and a present.
Authors: V T DeVita
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.3.867 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9060521 The war on cancer has a birthday, and a present. V T DeVita JrxV T DeVita JrSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.3.867 First Page PDF © 1997 by American Society of Clinical Oncology
Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials
Authors: Jonathan H. Esensten, Jeffrey A. Bluestone, Wendell A. Lim
Journal: Annual Review of Pathology Mechanisms of Disease (2016)

Engineered T cells are currently in clinical trials to treat patients with cancer, solid organ transplants, and autoimmune diseases. However, the field is still in its infancy. The design, and manufacturing, of T cell therapies is not standardized and is performed mostly in academic settings by competing groups. Reliable methods to define dose and pharmacokinetics of T cell therapies need to be developed. As of mid-2016, there are no US Food and Drug Administration (FDA)-approved T cell therapeutics on the market, and FDA regulations are only slowly adapting to the new technologies. Further development of engineered T cell therapies requires advances in immunology, synthetic biology, manufacturing processes, and government regulation. In this review, we outline some of these challenges and discuss the contributions that pathologists can make to this emerging field.
Enhanced Th2 cell differentiation and function in the absence of Nox2
Authors: B.-I. Kwon, T. W. Kim, K. Shin, Y. H. Kim, C. M. Yuk, J.-M. Yuk, D.-M. Shin, E.-K. Jo, C.-H. Lee, S.-H. Lee
Journal: Allergy (2016)

Patients with chronic granulomatous disease (CGD), whom inherit abnormal function of NADPH oxidase 2 (Nox2), suffer from hyperinflammatory responses in lung as well as bacterial and fungal infection. There have been studies to reveal the function of Nox2 in hyperinflammatory diseases, especially in asthma, but the exact role of Nox2 in asthma is still unclear and controversial. Therefore, we attempted to clarify the exact role of Nox2 in asthma, using various experimental asthma models.Asthma phenotypes were analyzed in response to various allergen-induced experimental asthma using Nox2-deficient mice and recombinase gene-activating-1-deficient mice. To understand the underlying mechanisms of exaggerated Th2 effector functions, we investigated the degree of T-cell activation, levels of activation-induced cell death (AICD), and regulatory T (Treg)-cell differentiation in Nox2-deficient T cells.Asthma phenotypes were increased through enhanced Th2 differentiation and function in Nox2-null mice regardless of dose and route of various allergens. Nox2-deficient T cells also showed hyperactivation, reduced AICD, and diminished Treg-cell differentiation through increased AKT phosphorylation (T308/S473) and enhanced mitochondrial ROS production.Our findings indicate that Nox2 deficiency results in exaggerated experimental asthma, which is caused by enhanced Th2 effector function in a T-cell-intrinsic manner.
Endoscopic extraction of a fish bone with a Foley catheter after endovascular stent graft placement for penetrating aortoesophageal injury
Authors: Xiangjiu Ding, Qingbo Su, Ning Zhong, Jianjun Jiang
Journal: Endoscopy (2015)

A 55-year-old man was admitted with retrosternal pain and odynophagia of 5 days' duration. The patient had ingested a fish bone just before the onset of symptoms. He had a 4-year history of coronary artery disease and myocardial infarction. Computed tomography showed a foreign body penetrating through the esophagus into the thoracic aorta ( [Fig.1]). No signs of mediastinitis were identified.