tbuckley/cabot-search huggingface dataset:
Abstract 3876: Actionable somatic mutations in head and neck cancer prognosis
Authors: Omar L. Nelson, Evan S. Wu, Jong Y. Park, Joseph Zeitouni, Carmen R. Gomez, Isildinha M. Reis, Wei Zhao, Eunkyung Lee, Hui-Yi Lin, Elizabeth J. Franzman, Jason Savell, Thomas V. McCaffrey, W. Jarrard Goodwin, Jennifer J. Hu
Journal: Cancer Research (2015)

Abstract Head and neck squamous cell carcinoma (HNSCC) is a devastating illness with racial/ethnic disparities in survival. Using a retrospective study design, we evaluated 210 somatic mutation sties of 10 cancer genes (i.e., CDKN2A, EGFR, FGFR3, HRAS, KRAS, MET, NOTCH1, PIK3CA, STK11, and TP53) in 214 HNSCC patients: 98 Non-Hispanic Whites (NHW; 46%), 72 Hispanic Whites (HW; 34%), and 44 African Americans (AA; 20%). HW and AA had significantly higher mutation rates for EGFR, HRAS, KRAS, and TP53 compared to that in NHW. Significantly higher proportions of HW (30%) and AA (18%) had at least 3 mutations compared to that in NHW (p&amp;lt;0.001). In logistic regression models using 2-year as the cut-off for early death, we evaluated the overall and racial/ethnic-specific somatic mutations that are associated with early death. Although there was no significant association between somatic mutation and early death in the total population, NOTCH1 mutations were significantly associated with early death in NHW (odds ratio [OR] = 5.51, 95% confidence internal [CI] = 1.22, 24.83). More importantly, the NOTCH1 mutation C6814T (P2272S) within the PEST domain was associated with early death (OR = 13.13 (95%CI = 1.61, 107.36). TP53 mutations were significantly associated with early death in HW (OR = 3.84; 95%CI = 1.08, 13.68) in multivariate analysis after adjustment for age, gender, tumor site, and tumor stage. With limited sample size, no association was observed in AA. This is the first pilot study evaluating the association between somatic mutations and HNSCC early death in a tri-racial/ethnic population. Our data suggest that HW and AA have higher EGFR mutations and these patients may benefit from mutation-targeted precision medicine to improve survival. Citation Format: Omar L. Nelson, Evan S. Wu, Jong Y. Park, Joseph Zeitouni, Carmen R. Gomez, Isildinha M. Reis, Wei Zhao, Eunkyung Lee, Hui-Yi Lin, Elizabeth J. Franzman, Jason Savell, Thomas V. McCaffrey, W. Jarrard Goodwin, Jennifer J. Hu. Actionable somatic mutations in head and neck cancer prognosis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3876. doi:10.1158/1538-7445.AM2015-3876
Mastery of stress: psychosocial aspects
Authors: G Caplan
Journal: American Journal of Psychiatry (1981)

Psychological stress may increase an individual's vulnerability to mental and physical illness. This may be prevented if the individual receives social support in mastering the stressful situation in the form of cognitive guidance that compensates for the inevitable reduction in his problem-solving capacity caused by stress-induced emotional arousal. This guidance should also help the individual or compensate for this arousal and enable him to come to terms with inescapable changes in his life produced by the experience. Empirical researches confirm that exposure to high stress by individuals receiving adequate support does not increase the risk of mental and physical illness.
THU0563 Prognostic Value of the 2014 Hscore in Adult Hemophagocytic Syndrome: Analysis in 111 Consecutive Patients (Reghem-Geas-Semi Spanish Cohort)
Authors: P. Brito Zeron, P. Moral Moral, A. Martínez Zapico, G. Fraile, E. Fonseca, P. Pérez Guerrero, A. Robles, M. Vaquero Herrero, A. Ruiz De Temiño, M.J. Forner, J.R. Larrañaga, S. Prieto, R. Hurtado, M. Ruiz Muñoz, M. Rodriguez, L. Caminal, A. Chamorro, M.A. Calvo, X. Bosch, P. Castro, M. Ramos-Casals
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> HScore is a numeric scoring system recently proposed by Fardet et al in 2014, designed to estimate the risk of having hemophagocytic syndrome (HS) in adults. <h3>Objectives</h3> The objective of this study is to analyze the potential use of the HScore as a prognostic factor in a large cohort of Spanish patients with adult HS. <h3>Methods</h3> In June 2013, the Study Group of Autoimmune Diseases (GEAS-SEMI) created the National Registry of Adult Patients with HS. Patients were diagnosed according to the fulfillment of the Histiocytosis Society criteria proposed in 1991 and updated in 2004. The HScore includes 9 clinical, laboratory and histopathological criteria, and the score may range from 0 to a maximum of 337 points. <h3>Results</h3> By January 2015, the REGHEM registry included 111 adult patients with HS, 65 (59%) men and 46 (41%) women, with a mean age at diagnosis of 49.16 years (range 12-85 years); nineteen patients (17%) were not born in Spain (58% from Latin America, 21% from Africa and 16% from Asia). Tissular hemophagocytosis was confirmed in 97/107 (87%) cases. The main underlying diseases diagnosed before HS were autoimmune/rheumatological diseases in 36 (33%) patients, chronic infections in 24 (22%) and neoplasia in 25 (23%) patients. The great majority of patients required ICU admission and death occurred in 59 (53%). The HScore was retrospectively calculated in 61 patients in whom all the criteria required could be applied: the mean HScore was 230,03 (range, 58-306). No significant differences for the mean HScore were found with respect to gender, age at diagnosis, underlying diseases, or severe internal organ involvement (pulmonary, renal or central nervous system). However, a higher mean HScore was found in foreign patients (257 vs 222, p=0.02), in patients with concomitant infections with confirmed microbiological isolation (243 vs 214, p=0.022) and in those who required vital support (248 vs 212, p=0.004). Patients who died showed a higher mean HScore in comparison with survivors (241 vs 217, p=0.05). <h3>Conclusions</h3> Hemophagocytic syndrome is a life-threatening multisystemic disease that often requires vital support in intensive care units. Despite this and the use of a complex therapeutic approach, half of the patients died. We found higher HScores in patients presenting with a complicated HS (concomitant infections, need for vital support and death). The use of the new HScore as prognostic factor may help to identify patients with a poor outcome. <h3>Disclosure of Interest</h3> None declared
An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior
Authors: Yonwoo Jung, Lawrence S Hsieh, Angela M Lee, Zhifeng Zhou, Daniel Coman, Christopher J Heath, Fahmeed Hyder, Yann S Mineur, Qiaoping Yuan, David Goldman, Angelique Bordey, Marina R Picciotto
Journal: Nature Neuroscience (2016)
Three cases of manic-depressive illness in mentally retarded adults
Authors: M K Hasan, R P Mooney
Journal: American Journal of Psychiatry (1979)

The authors point out that manic-depressive illness is often not diagnosed in mentally retarded patients because they are already regarded as "different." They discuss the use of lithium carbonate as a prophylactic agent in the treatment of manic-depressive illness in mentally retarded patients and present three case histories illustrating some of the difficulties encountered in diagnosing mania or hypomania in such patients. They provide a number of suggestions to help physicians recognize and treat these disorders.
Herpes-Like Particles in an American Lymphoma: Preliminary Note
Authors: Gregory T. O'Conor, M.D., Alan S. Rabson, M.D.
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Herpes-Like Particles in an American Lymphoma: Preliminary Note Get access Gregory T. O'Conor, M.D., Gregory T. O'Conor, M.D. Pathologic Anatomy Branch, National Cancer Institute,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Alan S. Rabson, M.D. Alan S. Rabson, M.D. Pathologic Anatomy Branch, National Cancer Institute,3Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 35, Issue 5, November 1965, Pages 899–903, https://doi.org/10.1093/jnci/35.5.899 Published: 01 November 1965 Article history Received: 18 August 1965 Published: 01 November 1965
Mammalian Chromosomes &lt;italic&gt;in Vitro&lt;/italic&gt;. VI. Observations on Mitosis with Phase Cinematography&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: T. C. Hsu
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Mammalian Chromosomes in Vitro. VI. Observations on Mitosis with Phase Cinematography Get access T. C. Hsu T. C. Hsu Tissue Culture Laboratory and Department of Anatomy, University of Texas—Medical Branch, Galveston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 3, December 1955, Pages 691–707, https://doi.org/10.1093/jnci/16.3.691 Published: 01 December 1955 Article history Received: 01 April 1955 Published: 01 December 1955
Severe Deafness in Infant Following Oral Administration of Neomycin
Authors: J T KING
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P74 CD161 expressing CD8+ T-cells; elusive players in viral hepatitis
Authors: L Walker, Y Kang, M Smith, Y Oo, E Barnes, G Lauer, D H Adams, P Klenerman
Journal: Gut (2010)

Hepatitis B (HBV) and C (HCV) -specific CD8+ T-cells are characterised by expression of the NK receptor CD161. CD8+ T cells with high levels of CD161 (CD161++) make up a mean of 12% of CD8+ T-cells in healthy controls and have distinct properties; they express the gut and liver homing chemokine receptors CCR6 and CXCR6, cytokines IL-17, IFN-y and IL-22 and have narrow TCR Vb usage (predominantly Vb 7.2 and 13), linking them to the mucosal-associated invariant T-cells of the gut. In healthy controls ∼40% of this CD161++ subset does not express the co-receptor CD8 alpha-beta (CD8ab), but the co-repressor CD8 alpha-alpha (CD8aa), yet share key functional and phenotypic features of the subset.  Aim  We aimed to the study the distribution and phenotype of CD8ab and CD8aa subsets in chronic hepatitis C (cHCV) and hepatitis B (cHBV).  Method  Flurochrome-labelled antibodies were used for multi-colour FACS analysis of lymphocytes in whole blood from 24 cHCV, 6 e-antigen (Ag) +ve HBV and 14 eAg−ve HBV patients and 19 healthy controls (HC). Liver infiltrating lymphocytes (LILs) (obtained from explant material; 4 HCV patients with paired PBMCs, eight alcoholic liver disease and 1 PBC) were included in the study. FACS data were analysed using FloJo software (Tree Star, Inc) and statistics were performed using PRISM (Graftpad software, Inc).  Results  CD8aa cells are exclusive to the CD161++ subset in HCs, cHCV and cHBV. In cHCV and eAg−ve cHBV there is a significant reduction in the proportion of cells in the CD161++CD8+ subset compared to HCs (p≤0.05). Within the CD161++CD8+ subset there is a further reduction in the fraction of CD8aa cells in cHCV patients (18.5% vs 34.13%, p=0.0086) compared to HCs. No difference is observed in cHBV. CD8ab and CD8aa CD161+ populations are found within human LILs in HCV, ALD and PBC. The CD161+CD8aa cell subset constitute a mean of 9.9% of the total CD8+ LILs. Relative enrichment of CD161+CD8aa cells is seen in the liver of patients with cHCV compared to peripheral blood (p=0.0079). In eAg−ve cHBV a distinct CD8a+blow population can be identified within the CD161+ and CD161− subsets. These populations are not seen in HCs, eAg+ve HBV and HCV (p  Conclusion  CD161++ CD8+ T-cells are lost from the peripheral blood in cHCV and eAg−ve HBV. Maintenance of this subset in eAg+ve HBV may reflect immuno-tolerance to virus at this stage of infection. In chronic HCV there is a relative enrichment of the CD161+CD8+ subset in LILs, indicating recruitment to and retention in the liver. The role of these cells in health, immunity and disease outcome in viral hepatitis requires further study. The emergence of a CD161+/CD161-CD8a+blow subset in eAg−ve HBV may reflect activation or exhaustion of these cells; their phenotype and function requires investigation.
SAT0012 Proteinase K-Like Serine Protease PCSK9 Influence on the Dyslipidemia Observed in Rheumatoid Arthritis Patients
Authors: B.T. Segura, R. Lόpez Mejías, F. Genre, B. Ubilla, E. Delgado-Frías, V. Hernández-Hernández, A.M. Vera-González, A. González-Rivero, F. Díaz-González, M. Ά. González-Gay, I. Ferraz-Amaro
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Proteinase K-like serine protease PCSK9 binds the low-density lipoprotein (LDL) receptor at the surface of hepatocytes, thereby preventing its recycling and enhancing its degradation in endosomes/lysosomes, resulting in reduced LDL-cholesterol clearance. Therefore, gain-of-function in PCSK9 lead to higher levels of LDL-cholesterol and increased risk of cardiovascular disease. <h3>Objectives</h3> To investigate how PCSK9, one of the molecules involved in the metabolism of LDL-cholesterol, is expressed in patients with rheumatoid arthritis (RA) and its potential relationship with the altered lipid profile observed in these patients. <h3>Methods</h3> Plasma PCSK9 concentrations were measured in 115 patients with RA and 101 matched controls. A multivariable analysis adjusted for glucocorticoid intake, standard cardiovascular risk factors, disease activity and lipids, including LDL cholesterol, was performed to evaluate the relation of PCSK9 with RA dyslipidemia compared to controls. <h3>Results</h3> Glucocorticoids-naïve RA patients showed lower levels of total cholesterol (216±39 vs 196±37 mg/dl, p=0.00), LDL cholesterol (135±36 vs 115±34 mg/dl, p=0.02), non-HDL cholesterol (161±40 vs 141±41 mg/dl, p=0.04) and apolipoproteins A1 (176±30 vs 162±32 mg/dl, p=0.01) and B (91±17 vs 82±18 mg/dl, p=0.00), compared to the control population. These differences were not found when control population was compared to patients treated with glucocorticoids. Resistin leves were higher in patients with RA (5.51±3.10 vs 6.27 [4.54-9.42], p=0.00), independently of glucocorticoid use. Conversely, while patients treated with corticosteroids showed no difference in PCSK9 levels compared to controls, these were significantly lower in glucocorticoids-naïve patients than controls (2.68±1.46 vs 2.22±1.18 μg/ml, p=0.03). LDL:HDL ratio cholesterol was not related with PCSK9 levels in RA patients or controls. PCSK9 levels showed no relation with parameters of activity or inflammation related to the disease. <h3>Conclusions</h3> PCSK9 is down regulated in glucocorticoids-naïve RA patients.This is independent of the decrease in LDL cholesterol that the disease expresses. <h3>Disclosure of Interest</h3> None declared
AB0730 Pulmonary Involvement in Patient Diagnosed with Morphea
Authors: T. Backa (Cico), A. Zoto, E. Rapushi, E. Ktona, Z. Ylli, M. Tanka
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Morphea is a form of localized scleroderma characterized from the presence of sclerotic plates localized in the skin. It may be in the form of plaque morphea or generalized. Usually morphea does not associate with systemic involvement, however anti-nuclear antibody (ANA), ds-DNA, etc, are measured in peripherial blood. <h3>Objectives</h3> Idenification of pulmonary involvement in morphea. <h3>Methods</h3> We studied 18 patients diagnosed with morphea. All patient were tested for auto-antibodies: ANA, ENA, Scl-70, anti RNP, ANCAp/c, anti-Sm, anticentrome antibudies. The patient underwent chest x-ray, pulmonary function test, HRCT of the lung. <h3>Results</h3> 12 from 18 patient that we studied resulted with plaque morphea (PM) and the other 6 patients with generalized morphea (GM). We found the presence of ANA the titer ≥1/320 in 8 patient (5 patient with GM and 3 patient with PM). The laboratory results for ds-DNA, ANCAp/c, Scl-70, anti-Sm, anticentromer antibody were negative in all patients. The chest x-ray resulted with interstitial involvement of the lungs of the reticular pattern in 7 patient (5 patient with GM and positive ANA and 2 patient with PM). HRCT in this patients showed the presence of interstitial infiltrate, while pulmonary function test resulted with mild to moderate restrictive syndrome. <h3>Conclusions</h3> Pulmonary involvement is found more frequently in the generalized form of morphea. The patient that resulted positive for ANA have a higher risk for developing pulmonary involvement. Anyway the pulmonary involvement in morphea is moderate. <h3>Disclosure of Interest</h3> None declared
Impact of neuroleptic chemotherapies on schizophrenic psychoses
Authors: P Deniker
Journal: American Journal of Psychiatry (1978)

The author reviews the impact of neuroleptic chemotherapy on various forms of schizophrenia in the 25 years since the introduction of chlorpromazine in psychiatry. The activities of the different types of compounds are related to the symptomatic and progressive forms of the psychosis, with an emphasis on the "dual structure" of the illness. Problems of drug efficacy, the need for new drug treatments, and methodological issues in research in these areas are discussed.
Explaining financial and prosocial biases in favor of attractive people: Interdisciplinary perspectives from economics, social psychology, and evolutionary psychology
Authors: Dario Maestripieri, Andrea Henry, Nora Nickels
Journal: Behavioral and Brain Sciences (2016)

Abstract Financial and prosocial biases in favor of attractive adults have been documented in the labor market, in social transactions in everyday life, and in studies involving experimental economic games. According to the taste-based discrimination model developed by economists, attractiveness-related financial and prosocial biases are the result of preferences or prejudices similar to those displayed toward members of a particular sex, racial, ethnic, or religious group. Other explanations proposed by economists and social psychologists maintain that attractiveness is a marker of personality, intelligence, trustworthiness, professional competence, or productivity. Evolutionary psychologists have argued that attractive adults are favored because they are preferred sexual partners. Evidence that stereotypes about attractive people are causally related to financial or prosocial biases toward them is weak or nonexistent. Consistent with evolutionary explanations, biases in favor of attractive women appear to be more consistent or stronger than those in favor of attractive men, and biases are more consistently reported in interactions between opposite-sex than same-sex individuals. Evolutionary explanations also account for increased prosocial behavior in situations in which attractive individuals are simply bystanders. Finally, evolutionary explanations are consistent with the psychological, physiological, and behavioral changes that occur when individuals are exposed to potential mates, which facilitate the expression of courtship behavior and increase the probability of occurrence of mating. Therefore, multiple lines of evidence suggest that mating motives play a more important role in driving financial and prosocial biases toward attractive adults than previously recognized.
Anatomical Studies of Ampulla of Vater
Authors: S E CARROLL
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal