tbuckley/cabot-search huggingface dataset:
AB0157 Serum Level of the Vascular Endothelial Growth Factor is Elevated in Ankylosing Spondylitis and Osteocalcin May be Related Wth Osteoproliferation: Table 1
Authors: D. Solmaz, H. Bulbul, S. Uslu, L.D. Kozaci, N. Karaca, S. Akar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic rheumatic disease characterized by sacroiliac and spinal inflammation and new bone formation (syndesmophyte). Molecular mechanisms underlying this process have not been yet fully understood however differentiation of mesenchymal cells into bone-forming osteoblasts appears to be a key pathogenic event. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and have some pro-inflammatory activity. It has also been suggested that VEGF may be relevant for new bone formation in AS. <h3>Objectives</h3> To evaluate the serum VEGF and osteocalcin levels in patients with AS. We also assessed the relationship among VEGF/osteocalcin levels and disease related parameters including radiographic outcomes. <h3>Methods</h3> In total 98 consecutive AS patients (77 males [79%]; with a mean age of 39.3±10.0 years) according to the modified New York criteria and 49 healthy controls (37males [76%]; with a mean age of 39.0±5.9 years) from two centers were included in the study. Serum VEGF, osteocalcin, interleukin (IL)-8, IL-6 levels were measured by commercially available ELISA kits. We also determined the serum high-sensitivity C-reactive protein (hs-CRP) levels. Disease related characteristics of patients were assessed by using BASDAI, BASFI, BASMI. Radiographs of the pelvis, cervical and lumbar spine were scored by using the modified New York and modified Stokes ankylosing spondylitis spinal score (mSASSS). <h3>Results</h3> Age and sex distribution were not different between AS patients and control subjects. As expected hs-CRP levels and erythrocyte sedimentation rate were higher in AS patients in comparison with controls. Serum VEGF level was found to be significantly higher in our AS patients compared with controls. In our study group serum VEGF levels were correlated with hs-CRP (rho=0.285 and <i>P</i>=0.005), ESR (rho=0.247 and <i>P</i>=0.015), IL-6 level (rho=0.380 and <i>P</i>&lt;0.001), IL-8 (rho=0.400 and <i>P</i>&lt;0.001) and ASDAS-CRP (rho=0.203 and <i>P</i>=0.048). Serum VEGF level was found to be not associated with hip involvement, sacroiliac joint ankylosis or presence of the syndesmophyte. Our study showed that although serum osteocalcin level was not statistically different in AS patients and controls it was significantly higher in patients with sacroiliac joint ankylosis and hip involvement. <h3>Conclusions</h3> The results of the present study showed that VEGF may be a good indicator of disease activity in AS and osteocalcin may have a role in new bone formation. <h3>Disclosure of Interest</h3> None declared
A New Quantitative Index for Baseline Renal Transplant Scintigraphy With 99mTc-DTPA in Evaluation of Delayed Graft Function and Prediction of 1-Year Graft Function
Authors: Bulent Yazici, Aylin Oral, Cenk Gokalp, Aysegül Akgün, Huseyin Toz, Cuneyt Hoscoskun
Journal: Clinical Nuclear Medicine (2015)

Purpose The aims of this study were to assess quantitative indices of baseline renal transplant scintigraphy (RTS) with 99mTc-DTPA for evaluation of delayed graft function (DGF) and prediction of 1-year graft function and to describe a new inclusive index for RTS. Patients and Methods A total of 179 patients to whom RTS with 99mTc-DTPA was performed within 2 days after kidney transplantation were analyzed retrospectively. Hilson perfusion index, perfusion time (ΔP), peak-to-plateau ratio, peak perfusion-to-iliac artery ratio, T½ of graft washout, peak perfusion-to-uptake ratio, and ratio of uptake at 20 to 3 minutes (R20/3) were obtained. In addition, we first described the following formula defined as graft index (GI): GI = (ΔP × arterial peak × plateau)/(perfusion peak × uptake at 3 minutes). At 1 year, a serum creatinine level of more than 1.5 mg/dL was considered to be abnormal. Mann-Whitney U, Spearman coefficient of correlation test, and receiver operating characteristic curve were used for statistical analyses. P < 0.05 was considered statistically significant. Results Mean values of all the indices were significant. The most accurate, sensitive, and specific index for both identification of DGF and prediction of 1-year serum creatinine level of more than 1.5 mg/dL was GI. Area under the curve of GI was 0.94 for identification of DGF and 0.79 for 1-year prediction. Conclusions The question is, “Which index is the best indicator?” This study demonstrated that the parameters of ΔP, plateau, arterial peak, perfusion peak, and uptake at 3 minutes of RTS could be assessed together by the formula of GI, which provides more accurate information to identify DGF and predict 1-year graft function.
Drug Combination Studies and Their Synergy Quantification Using the Chou–Talalay Method—Letter
Authors: John C. Ashton
Journal: Cancer Research (2015)

Advances in the theory of combination therapy ([1][1]) and development of new targeted drugs are leading to a new emphasis on drug combination experiments. Many studies continue to use the median-effect method of Chou–Talalay ([2][2]). However, the median-effect method follows a similar logic to
Nephrotoxicity of Amphotericin B
Authors: M A Carlson, R E Condon
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Case of Cerebral Aspergillosis
Authors: S OLSEN, K R ERIKSEN, A STENDERUP, J T BALSLOV
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Iodine 131 antiferritin, a new treatment modality in hepatoma: a Radiation Therapy Oncology Group study.
Authors: S Hellman
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.12.1569 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2999345 Iodine 131 antiferritin, a new treatment modality in hepatoma: a Radiation Therapy Oncology Group study. S HellmanxS HellmanSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.12.1569 PDF "Iodine 131 antiferritin, a new treatment modality in hepatoma: a Radiation Therapy Oncology Group study.." Journal of Clinical Oncology, 3(12), p. 1569© 1985 by American Society of Clinical Oncology
PWE-208 How common is pancreatic exocrine insufficiency in primary care?
Authors: JA Campbell, KA Francis, M Kurien, AD Hopper, D Joy, S Lee, A Ramadas, H Taha, DS Sanders
Journal: Gut (2015)

Introduction The prevalence of chronic pancreatitis in post mortem studies is between 6–12%. We previously studied over 1800 all-comers to secondary care gastroenterology and found 14.4% had low faecal elastase-1 (FEL-1) suggestive of exocrine pancreatic insufficiency (EPI). We sought to investigate if there were similar rates in primary care. Method A retrospective analysis of primary care patients tested for EPI between 2009–13 was performed. FEL-1 <200 was considered abnormal. Demographics, indication, co-morbidities and response to Creon were noted. Patients were excluded if the test originated in secondary care. Pancreatic imaging results were noted. Logistic regression helped determine if co morbidity or symptom could predict EPI. Comparisons were made with the secondary care cohort. Results 168 primary care patients and 1887 ssecondary care patients were identified. The mean age in primary care was 59.74 (SD 16.26, 98 female) cf secondary care mean age 51.60 (SD 16.91, 1144 female) p < 0.0001. The most frequent indications to test in primary care were diarrhoea (60.1% 101/168), weight loss (14.9% 25/168) and abdominal pain (13.1% 22/168). In secondary care the most common indications were diarrhoea (68.4% 1252/1887), abdominal pain (20.0% 378/1887) and weight loss (6.6% 125/1887). The overall prevalence of EPI in primary care was 20.2% (FEL-1 <200) and 11.9% (FEL <100). In secondary care the overall prevalence of EPI was 14.4% (FEL-1 <200) and 8.6% (FEL-1 <100). In primary care patients with weight loss, abdominal pain and diarrhoea the rates of FEL-1 <200 were 28.0% (7/25), 18.2% (4/22) and 16.8% (17/101) respectively. 79.4% (27/34) of primary care patients with FEL-1 <200 had abdominal imaging (CT/MRI/USS); pancreatic pathology was detected in 59.6% (16/27). 86.8% of secondary care patients with FEL-1 <200 had imaging; 38.1% (90/236) had pathology (p = 0.04). Weight loss and steatorrhoea were significantly associated with FEL-1 <200 using binary logistic regression (p < 0.05). Diabetes mellitus, coeliac disease and excess alcohol consumption were strongly associated with pancreatic insufficiency (p < 0.05). 76.5% (26/34) patients had documented pancreatic enzyme supplementation, of which 80.7% (21/26) reported symptomatic relief. 7.7% reported no benefit and 11.5% were unable to tell. Conclusion This is the first primary care study reporting a prevalence of exocrine pancreatic insufficiency (20.2%). Primary care physicians are correctly identifying patients for testing presenting with weight loss and steatorrhoea, as well as considering the associations of diabetes, coeliac disease and excess alcohol. Imaging and symptomatic benefit (from Creon) supports their diagnosis in almost 60% and 80% respectively. Disclosure of interest None Declared.
Medicine and multimedia: The General Practice Management Handbook
Authors: Roland Petchey
Journal: BMJ (1998)

Eds P Orton, C Hill


W B Saunders, £18.95, pp 276 




ISBN 0 7020 2204 7

———————

Rating: ★★

Management handbooks are a peculiar literary genre. They are obliged to present management as straightforward and commonsensical (in order to appeal to the pragmatic nature of managers), but beneath this veneer of practicality they are intensely ideological texts. They offer a particular and partial perspective on organisations and the world of work. Typically, they portray organisations as consensual and the managerial perspective as unconditionally legitimate. Crucially, they seek to reduce the processes of planning and management to an exercise in formal logic. In reality, of course, these assumptions rarely apply. Organisations (even small ones) actually consist of individuals with differing world views and priorities. Because some of them may dispute the manager’s right to manage (ask any doctor), management is inescapably political.

The concept of management becomes even more problematic when we try to apply it to hybrid organisations such as general practices. Exactly what sort of organisations are they? Are they teams? Maybe, but they incorporate a variety of professional subcultures as well as a professional hierarchy (not to mention that most team members are employees of a minority).

Are they small businesses? Perhaps, but what sort of business are you left with if commercial risk and competition do not operate? Are they partnerships? Possibly, but hitherto most partnerships have functioned as little more than arrangements for sharing premises and staff (so called “docs in a box”). As organisations, general practices remain a black box.

I have some problems with this book. Its multidisciplinary authorship is a strength, but its intended readership is unclear (perhaps deliberately). Some of the content is obviously aimed at general practitioners, but most is non-specific. Once or twice it raises the possibility (no more) of primary healthcare teams that are not led by general practitioners, but in general its perspective is thoroughly GP-centric. It is striking that it does not refer to the practice manager (only to “practice management” in the abstract). Consequently, it neatly sidesteps the division of management labour between general practitioners and the nominal “practice manager.”

Although the book offers a historical and policy context, policy changes while it was in preparation mean that much of the presentation now feels slightly dated. Many of its underlying assumptions (especially concerning the sovereignty of the practice) are outmoded. While much of its content is transferable, it has little to offer on some key management challenges of the future. How do we move beyond the practice to primary care groups and primary care trusts? What management resources and skills will they require? Who will supply them? What will clinical governance mean and how will it be delivered?
Colon and Ovarian Tumor Antigen in Human Colon Tumors Grown In Culture and In Athymlc Mice&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: P. O. Zamora, K. D. Pant, K. Sass, E. Barry, C. Tabet, B. A. Rhodes, R. Hay
Journal: JNCI Journal of the National Cancer Institute (1986)

Colon and Ovarian Tumor Antigen in Human Colon Tumors Grown In Culture and In Athymlc Mice Get access P. O. Zamora, P. O. Zamora Summa Medical Corporation, 4272 Balloon Park Road N.E., Albuquerque, New Mexico 87109 Search for other works by this author on: Oxford Academic PubMed Google Scholar K. D. Pant, K. D. Pant Summa Medical Corporation, 4272 Balloon Park Road N.E., Albuquerque, New Mexico 87109 Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Sass, K. Sass Summa Medical Corporation, 4272 Balloon Park Road N.E., Albuquerque, New Mexico 87109 Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Barry, E. Barry Summa Medical Corporation, 4272 Balloon Park Road N.E., Albuquerque, New Mexico 87109 Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Tabet, C. Tabet Summa Medical Corporation, 4272 Balloon Park Road N.E., Albuquerque, New Mexico 87109 Search for other works by this author on: Oxford Academic PubMed Google Scholar B. A. Rhodes, B. A. Rhodes RhoMed, Inc., 1104 Stanford N.E., Albuquerque, New Mexico 87106 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. Hay R. Hay American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 76, Issue 5, May 1986, Pages 977–979, https://doi.org/10.1093/jnci/76.5.977 Published: 01 May 1986
Lateralization of dementia of depression in stroke patients
Authors: K Bolla-Wilson, R G Robinson, S E Starkstein, J Boston, T R Price
Journal: American Journal of Psychiatry (1989)

In a group of stroke patients with left-hemisphere lesions, those with major depression performed significantly below nondepressed patients on four of nine cognitive domains examined with a neuropsychological test battery. Among patients with right-hemisphere stroke, those with major depression did not perform below nondepressed patients on any of the nine cognitive domains. The differential effect of depression on cognitive performance between left- and right-hemisphere lesion groups could not be accounted for by demographic variables, neurological symptoms, lesion location, or lesion size. Poststroke major depression appeared to produce a decline in cognitive performance or dementia of depression that depended on the laterality of the lesion.
Laboratory response of patients with panic and obsessive-compulsive disorders to 35% CO2 challenges
Authors: G Perna, A Bertani, C Arancio, P Ronchi, L Bellodi
Journal: American Journal of Psychiatry (1995)

The DSM-III-R anxiety disorders section includes both panic disorder and obsessive-compulsive disorder. To evaluate the relationship between these two disorders, subject responses to inhalation of a 35% CO2 and 65% O2 mixture were assessed.Twenty-three patients with panic disorder, 23 with obsessive-compulsive disorder, 12 with both obsessive-compulsive and panic disorder, and 23 healthy comparison subjects were given a single vital capacity inhalation of 35% CO2 and 65% O2 or a placebo mixture of compressed air. A double-blind, random, crossover design was used.Patients with panic disorder and patients with both panic disorder and obsessive-compulsive disorder showed similar strong anxiogenic reactions to 35% CO2; while patients with obsessive-compulsive disorder alone did not differ from comparison subjects.These results confirm that obsessive-compulsive disorder and panic disorder are two distinct syndromes and that patients with these disorders have different sensitivity to CO2 inhalation.
Etiologic Implications of the Racial Incidences of Gastric Cancer&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Paul E. Steiner, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Etiologic Implications of the Racial Incidences of Gastric Cancer Paul E. Steiner, M. D. Paul E. Steiner, M. D. professor of pathology University of Chicago, Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 429–437, https://doi.org/10.1093/jnci/10.2.429 Published: 01 October 1949
Mammalian Chromosomes &lt;italic&gt;In Vitro&lt;/italic&gt;. XII. Experimental Evolution of Cell Populations&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: T. C. Hsu, Douglas S. Kellogg, Jr.
Journal: JNCI Journal of the National Cancer Institute (1960)

Strain L-P59, a subline of strain L clone 929 of the mouse, had a chromosome modality of 64 to 66 with 13 or 14 metacentrics. After the population had been treated with colchicine for 48 hours, cells in the modality zone (stem cells) were greatly reduced in number. The population was predominantly occupied by high polyploids and, in the stemline zone, by genomes less frequently observed in the original population. These were considered 3s metabolically second-rate genomes. The stem cells, as expected, regained dominance after several subcultures. After prolonged colchicine treatment, the cultures either shifted completely to double-stemline numbers or changed to genomes that were rarely found in the parental population. The modality dropped to below 60, and many “monstrous” chromosomes were recorded. The double-stemline strain was apparently the result of polyploidization of the stem cells; but the rare genomes were interpreted as those that escaped colchicine poison. While all the vigorous genomes were repeatedly poisoned by colchicine whenever they entered mitosis thereby becoming giant cells which lost the ability to give rise to cell lineage, these rare genomes, due to their inferior metabolic activities, did not divide during the period of treatment, thus escaping injury. Growth assays confirmed that these cells grew much slower than the parental types. Long-term colchicine treatment on cells in vitro may be used as a method for selecting metabolically inferior mutant genomes whose isolation would be otherwise difficult.
Mechanisms for interaction: Syntax as procedures for online interactive meaning building
Authors: Ruth Kempson, Stergios Chatzikyriakidis, Ronnie Cann
Journal: Behavioral and Brain Sciences (2016)

Abstract We argue that to reflect participant interactivity in conversational dialogue, the Christiansen &amp; Chater (C&amp;C) perspective needs a formal grammar framework capturing word-by-word incrementality, as in Dynamic Syntax, in which syntax is the incremental building of semantic representations reflecting real-time parsing dynamics. We demonstrate that, with such formulation, syntactic, semantic, and morpho-syntactic dependencies are all analysable as grounded in their potential for interaction.
Phylogenetic analysis of highly pathogenic avian influenza A(H5N8) virus outbreak strains provides evidence for four separate introductions and one between-poultry farm transmission in the Netherlands, November 2014
Authors: R J Bouwstra, G Koch, R Heutink, F Harders, A van der Spek, A R Elbers, A Bossers
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
Mandatory addiction treatment for people who use drugs: global health and human rights analysis: Table
Authors: Karsten Lunze, Bulat Idrisov, Mikhail Golichenko, Adeeba Kamarulzaman
Journal: BMJ (2016)

Global evidence indicates that mandated treatment of drug dependence conflicts with drug users' human rights and is not effective in treating addiction. <b>Karsten Lunze and colleagues</b> argue that drug treatment policies must be evidence based and meet international standards
Correcting outcome data for case mix in stroke medicine
Authors: D. Barer, J. Ellul, C. Watkins
Journal: BMJ (1996)

one when she can legally terminate the entire pregnancy.There are, however, grounds for caution if there is a lasting effect on the surviving twin.Through the Lone Twin Network, the Multiple Births Foundation meets a large number of adults whose twin died at or before birth and who feel the loss profoundly.How far this self selected group is representative is not known.Research on the long term psychological sequelae, including their prevalence and relative seriousness, is therefore badly needed.
TCT-53 Assessment of 30-Day Rehospitalization For Acute Myocardial Infarction In Patients With Acute Coronary Syndrome Who Received Percutaneous Coronary Intervention: A Comparative Effectiveness Study Of Clopidogrel And Prasugrel
Authors: Jay Bae, Douglas Faries, Frank Ernst, Craig Lipkin, Zhenxiang Zhao, Chad Moretz
Journal: Journal of the American College of Cardiology (2012)