tbuckley/cabot-search huggingface dataset:
Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) following a diagnosis of breast cancer
Authors: A. Padmanabhan, A. Block, S. Sait, L. A. Ford, T. L. O'Connor, K. B. Moysich, M. R. Baer
Journal: Journal of Clinical Oncology (2007)

7051 Background: Increasing use of chemotherapy and radiation therapy in breast cancer patients in the adjuvant setting heightens concern about therapy-related AML and MDS. Little is known about the characteristics of these disorders following breast cancer. Methods: Roswell Park Cancer Institute (RPCI) patients with diagnoses of MDS or AML by French-American-British Group or World Health Organization criteria following breast cancer were retrospectively reviewed. Results: 34 women were identified between 1983 and 2006. 10 (29%) were also diagnosed with additional malignancies, including non-Hodgkin lymphoma (NHL), bladder, colon, lung, uterine and thyroid cancers, Ewing sarcoma and angiosarcoma. 23 of 31 patients (74%) with family histories documented had first-degree relatives with cancers, including breast, lung, colon, stomach, pancreas, prostate, renal, melanoma, esophagus, thyroid, Hodgkin lymphoma and leukemia, compared to a 45% prevalence of first-degree relatives with cancer among 1982 control RPCI breast cancer patients (p= 0.001). Median age at breast cancer diagnosis was 58 (range, 37–85) years. Among the 29 patients with known treatment, 25 (86%) had received radiation therapy, 13 (45%) had received chemotherapy, including alkylating agents in all 13 (45%) and topoisomerase II inhibitors in 8(28%), while 4 (14%) had received no adjuvant therapy. Median age at AML/MDS diagnosis was 70 (range, 46–90) years. 26 patients had AML and 8 MDS, of whom 4 progressed to AML. Karyotypes were complex in 10 (29%), involved 11q23 rearrangements in 6 (18%), were favorable, normal and unknown in 5 each (45%), and had miscellaneous single structural abnormalities in 3 (9%); they did not strictly correlate with treatment received. Median survival (months) was 1 for complex karyotype, 6 for 11q23 translocation and 40 for favorable karyotype patients. Conclusions: The incidence of other cancers and of cancers in family members was unexpectedly high in breast cancer patients with AML and MDS, in the absence of known genetic syndromes, suggesting genetic polymorphisms predisposing to multiple cancers. Cytogenetic abnormalities included complex, 11q23 and favorable karyotypes, and survival reflected karyotypes. No significant financial relationships to disclose.
Association of Radiologically Ascertained Pneumonia Before Age 3 yr with Asthmalike Symptoms and Pulmonary Function During Childhood
Authors: JOSÉ A. CASTRO-RODRÍGUEZ, CATHARINE J. HOLBERG, ANNE L. WRIGHT, MARILYN HALONEN, LYNN M. TAUSSIG, WAYNE J. MORGAN, FERNANDO D. MARTINEZ
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

Epidemiologic evidence suggests an association between reports of pneumonia in early life and the subsequent development of diminished lung function. However, no studies are available in which the diagnosis of pneumonia was based on radiologic evidence. Lower respiratory illnesses with or without a radiologically confirmed diagnosis of pneumonia were assessed in a study of 888 children enrolled at birth. Pulmonary function tests, markers of atopy, asthma diagnosis, and prevalence of respiratory symptoms were assessed at different ages between birth and 11 yr. Incidence of pneumonia during the first 3 yr of life was 7.4%. Respiratory syncytial virus was the most frequent agent identified both in children with pneumonia and in those with lower respiratory tract illness (LRI) without pneumonia (36.4% versus 35.6%, respectively). Children with a diagnosis of pneumonia were more likely to have physician-diagnosed asthma and current wheezing at ages 6 and 11 yr than were those who had no LRIs. When compared with children without LRIs, those with a diagnosis of pneumonia had lower levels of maximal flows at FRC at mean age of 2 mo (albeit not significantly) and at age 6 yr, and lower levels of FEV1 and FEF25–75 at age 11 yr. These deficits were independent of known confounders, including wheezing at the time of study, and were partly and significantly reversed after administration of a bronchodilator. We conclude that children with radiologically confirmed pneumonia have diminished airway function that is probably present shortly after birth. These deficits are at least in part due to alterations in the regulation of airway muscle tone.
Effects of Hemipancreatectomy on Insulin Secretion and Glucose Tolerance in Healthy Humans
Authors: David M. Kendall, David E.R. Sutherland, John S. Najarian, Frederick C. Goetz, R. Paul Robertson
Journal: New England Journal of Medicine (1990)

Pancreatic tissue obtained by hemipancreatectomy from healthy living related donors has been transplanted into recipients with Type I diabetes mellitus. To determine the metabolic consequences of this procedure for the donors, we carried out oral glucose-tolerance testing and 24-hour monitoring of serum glucose levels and urinary C-peptide excretion as a measure of insulin secretion in 28 donors, both before and one year after hemipancreatectomy.
Cultural adaptations to the differential threats posed by hot versus cold climates
Authors: Damian R Murray
Journal: Behavioral and Brain Sciences (2013)

Abstract Hot and cold climates have posed differential threats to human survival throughout history. Cold temperatures can pose direct threats to survival in themselves, whereas hot temperatures may pose threats indirectly through higher prevalence of infectious disease. These differential threats yield convergent predictions for the relationship between more demanding climates and freedom of expression, but divergent predictions for freedom from discrimination.
781 HEAT SHOCK PROTEIN 70 (HSP-70) A NOVEL SURROGATE MARKER FOR HYPOXIA INDUCED LIVER INJURY (HILI) - A PROSPECTIVE OPEN LEVEL CONTROL CLINICAL PILOT STUDY
Authors: P.P. Basu, T. Nair, S. Farhat, S. Foustin, M. Jafri, N. James Shah, L. Ang
Journal: Journal of Hepatology (2012)
EVALUATION OF CHRONIC TOTAL OCCLUSIONS BY COMBINED MULTI-DETECTOR COMPUTED TOMOGRAPHY AND INTRAVASCULAR ULTRASOUND IMAGING
Authors: Myong Hwa Yamamoto, Akiko Maehara, Michael Poon, Jun Guo, Kennosuke Yamashita, Tadayuki Yakushiji, Shigeo Saito, Gary Mintz, Masahiko Ochiai
Journal: Journal of the American College of Cardiology (2015)
EXAGGERATED EXERCISE BLOOD PRESSURE RESPONSE IS RELATED TO INCREASED ARTERIAL STIFFNESS, ASYMMETRIC DIMETHYLARGININE AND OSTEOPROTEGERIN IN ESSENTIAL HYPERTENSION
Authors: Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Athanasios Kordalis, Eirini Andrikou, Dimitris Flessas, Dimitris Tsiachris, Voula Pylarinou, Georgios Georgiopoulos, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2016)
Towards personalised treatment in primary Sjögren's syndrome: baseline parotid histopathology predicts responsiveness to rituximab treatment
Authors: Konstantina Delli, Erlin A Haacke, Frans G M Kroese, Rodney P Pollard, Stephan Ihrler, Bert van der Vegt, Arjan Vissink, Hendrika Bootsma, Frederik K L Spijkervet
Journal: Annals of the Rheumatic Diseases (2016)

Objectives The aims of this study were (1) to assess the effect of rituximab (RTX; anti-CD20) treatment in patients with primary Sjögren's syndrome (pSS) based on sequential parotid biopsies obtained in a placebo-controlled, randomised clinical trial, and (2) to assess the prognostic value of the histological characteristics of parotid gland tissue with regard to responsiveness to RTX treatment. Methods In a double-blinded, placebo-controlled trial, sequential parotid gland biopsies were taken from 20 RTX-treated and 10 placebo-treated patients with pSS, at baseline and 12 weeks after treatment. The relative amount of lymphocytic infiltrate (stained for CD45), absolute number of T cells and B cells per mm 2 parenchyma (stained for CD3 and CD20, respectively), focus score, number of germinal centres and of lymphoepithelial lesions per mm 2 in parotid gland parenchyma were assessed. Histopathological data were compared between clinical responders (decrease in European League Against Rheumatism Sjögren's Syndrome Disease Activity Index (ESSDAI) score of ≥3 at 12 weeks compared with baseline) and non-responders (change in ESSDAI&lt;3) to RTX treatment. Results In RTX-treated patients, a significant reduction in the number of CD20+ B cells/mm 2 parenchyma was observed, while no such reduction was observed in placebo-treated patients. The number of CD3+ T cells/mm 2 in parenchyma did not change in either group. Furthermore, the number and the severity of lymphoepithelial lesions/mm 2 and number of germinal centres/mm 2 was significantly reduced in RTX-treated patients, but did not change in placebo-treated patients. When comparing the pretreatment characteristics of clinical responders with non-responders, the median number of CD20+ B cells/mm 2 parenchyma at baseline was significantly higher in responders (1871 vs 353 cells/mm 2 , p&lt;0.05). Other histopathological baseline characteristics were not predictive for response to RTX treatment. Conclusions RTX treatment in pSS leads to a major reduction of lymphocytic infiltration and to fewer B cells, germinal centres and lymphoepithelial lesions in parotid gland parenchyma. A high pretreatment number of CD20+ B cells/mm 2 parotid gland parenchyma predicts better responsiveness of patients with pSS to RTX treatment. Pretreatment parotid gland histopathological characteristics could therefore contribute to a more personalised treatment approach to pSS.
FRESH ADIPOSE TISSUE DERIVED STEM CELLS SIGNIFICANTLY ENHANCE VENTRICULAR FUNCTION IN A CHRONIC PORCINE MYOCARDIAL INFARCTION MODEL
Authors: Alexander Haenel, Mohamad Ghosn, Daryl G. Schulz, Jody Vykoukal, Dipan Shah, Albert E. Raizner, Eckhard Alt
Journal: Journal of the American College of Cardiology (2015)
Retrieval of a long foreign body from the stomach with a duodenoscope
Authors: I. El Hajj, B. Clarke, A. Slivka
Journal: Endoscopy (2011)

Foreign body ingestion presents a common clinical problem facing gastroenterologists and surgeons. Most foreign bodies pass spontaneously but long objects in the range of 6 – 10 cm in length are less likely to pass the duodenal curve and often require removal from the stomach [1]. Endoscopic retrieval is challenging due to difficulties in orienting the object parallel to the esophagus in a secure fashion in order to facilitate removal through the lower esophageal sphincter (LES). We present a simple technique that avoided laparotomy in a patient presenting with a large retained gastric foreign body.
Digoxin-Induced Bidirectional Ventricular Tachycardia
Authors: S Valent, P Kelly
Journal: New England Journal of Medicine (1997)

Figure 1. A 71-year-old woman had recently undergone mitral-valve replacement after being treated with digoxin for 12 years for atrial fibrillation. After the operation, the same dose of digoxin was administered intravenously, despite rising creatinine levels. The 12-lead electrocardiogram in Panel A shows an alternating QRS axis that is characteristic of bidirectional ventricular tachycardia (arrows), an arrhythmia virtually diagnostic of digitalis toxicity. The serum digoxin level at the time of the electrocardiogram was 4.5 ng per milliliter (normal, 0.8 to 2.0). The tracing in Panel B, obtained after treatment with digoxin monoclonal antibody, shows resolution of the bidirectional ventricular tachycardia, . . .
SAT0300 Nail psoriasis per se does not predict psoriatic arthritis: Analysis of risk factors in a cohort of italian psoriatic patients:
Authors: G. De Marco, N. Battafarano, A. Cattaneo, A. Marchesoni
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Nail psoriasis is acknowledged to be associated with Psoriatic Arthritis (PsA). Onycho-Psoriasis (ONPS), however, is extremely common in psoriatic population and correlate poorly with skin involvement. Further, not all clinical subsets of PsA may be linked to ONPS. <h3>Objectives</h3> Our aim was to investigate clinical risk factors predictive for PsA in a population of psoriatic subjects. <h3>Methods</h3> Patients were enrolled in a dermatological clinic dedicated to psoriasis care. Subjects reporting muscolo-skeletal discomfort and/or articular swelling were referred to rheumatologist. Dermatological features (PASI score, age of onset, previous/current therapies) were recorded. Rheumatological parameters encompassed joint counts (tender, swollen, damaged), entheses counts and others as suggested in the international consensus. Patients also underwent radiographic evaluation of painful areas. PsA diagnosis was established through rheumatologist opinion. After univariate analysis for possible risk factors, a multivariate model was built for unconditional logistic regression. Statistical significance was set on P&lt;0.01. <h3>Results</h3> Overall, among 1200 subjects followed up at our center, 277 consecutive patients were evaluated (131 males). The mean age was 55.7 years (SD 13; median 58, range 21-81), 79.1% suffered from plaque psoriasis (41.8% had nail disease, 2.8% isolated ONPS). Median PASI score was 3.1 (IQR 1.2-5.8), 12.3% of patients had a score of 10 or more. Only 16% of patients had a previous diagnosis of PsA. We diagnosed 110 PsA, 59.1% of whom as consequence of enrolment. PsA was early (onset within 1 year since enrolment) in 33.6%. PsA was classified in 82.7% of cases as peripheral arthritis, 34.5% of patients had dactylitis and 15.5% showed axial disease. Radiographic damage due to PsA was present in 38.2% of cases. At univariate level, risk factors for PsA were: male sex; younger age at enrolment and at psoriasis onset. The multivariate analysis (shown in table 1) confirmed statistical significance only for male sex, although at low level (95% CI 1.3-3.9). <h3>Conclusions</h3> PsA seems to be hardly linkable to clinical parameters easily available in daily dermatological practice. Above all, our data alert for the first time that the mere presence of nail psoriasis does not confer increased risk for PsA. <h3>Disclosure of Interest</h3> None Declared
Influence of Aortocoronary Bypass Surgery on Left Ventricular Performance
Authors: Gareth Rees, J. David Bristow, E. Louise Kremkau, Gerald S. Green, Rodney H. Herr, Herbert E. Griswold, Albert Starr
Journal: New England Journal of Medicine (1971)

Abstract Quantitative analysis of left ventricular cineangiocardiograms was performed before and after aortocoronary-vein-bypass operations for angina pectoris in 14 selected patients. Eight patients with anatomically successful results had a decrease in left ventricular end-systolic volume, and an increase in ejection fraction and the rate of circumferential fiber shortening at the ventricular equator. In two, improvement in the motion of akinetic regions of the ventricular wall was found. Six other patients had anatomically unsatisfactory results, usually because of occlusion of the graft. Ejection fraction and fiber-shortening rate fell in these, and the end-systolic volume was higher after operation. End-diastolic volume was similar in both groups and was not consistently altered by operation. In patients without severe depression of ventricular performance, ventricular function improved when the operation was technically successful. Deterioration of function accompanied graft occlusion.
Abstract 355: CIP2A mediates effects of bortezomib on phospho-Akt and apoptosis in hepatocellular carcinoma cells
Authors: Kuen-Feng Chen, Chun-Yu Liu, Yu-Chin Lin, Hui-Chuan Yu, Tsung-Hao Liu, Duen-Ren Hou, Pei-Jer Chen, Ann-Lii Cheng
Journal: Cancer Research (2010)

Abstract Previously, we reported that Akt inactivation determines the sensitivity of hepatocellular carcinoma (HCC) cells to bortezomib (Chen et al, Cancer Res 2008). Here, we report that cancerous inhibitor of protein phosphatase 2A (CIP2A), a cellular inhibitor of protein phosphatase 2A (PP2A), mediates the apoptotic effect of bortezomib in HCC. Silencing PP2A by small interference RNA (siRNA) abolishes bortezomib-induced down-regulation of phospho-Akt and apoptosis. Bortezomib increases PP2A activity in sensitive HCC cells, including Sk-Hep1, Hep3B and Huh-7 but not in resistant PLC5 cells. Bortezomib down-regulates CIP2A in a dose- and time-dependent manner in all sensitive HCC cells whereas no alterations in CIP2A were found in resistant PLC5 cells. Knockdown of CIP2A by siRNA restored bortezomib's effects on apoptosis and PP2A activity in PLC5 cells. Moreover, over-expression of CIP2A up-regulated phospho-Akt and protected Sk-Hep1 cells from bortezomib-induced apoptosis. Importantly, ectopic expression of CIP2A decreased Akt-related PP2A activity whereas silencing CIP2A increased this activity, indicating that CIP2A negatively regulates Akt-related PP2A activity in HCC cells, Furthermore, our in vivo data showed that bortezomib down-regulates CIP2A and up-regulates PP2A activity in Huh-7 tumors but not in PLC5 tumors. In conclusion, inhibition of CIP2A determines effects of bortezomib on apoptosis and PP2A-dependent Akt inactivation in HCC. CIP2A may be a biomarker for predicting clinical response of bortezomib in HCC treatment. Supported by NTUH98P03, NTUH98FTN21, NSC97-2314-B-002-182, NSC98-2314-B-002-067-MY3, and NSC98-3112-B-002-037. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 355.
A1.19 Altered distribution of innate lymphoid cell populations in human LYMPH node biopsies obtained during the earliest phases of systemic autoimmunity
Authors: JS Hähnlein, J Rodriguez-Carrio, TH Ramwadhdoebe, JF Semmelink, IY Choi, KP van Lienden, M Maas, DM Gerlag, PP Tak, TBH Geijtenbeek, LGM van Baarsen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objective</h3> Innate lymphoid cells (ILCs) emerge as important mediators of immunity&nbsp;and accumulation of inflammatory ILC populations has been reported in various inflammatory-mediated conditions. We investigated&nbsp;the frequency and distribution of ILCs in lymph node biopsies obtained during the earliest phases of rheumatoid arthritis (RA). <h3>Materials and methods</h3> Twelve patients with early rheumatoid arthritis (RA), 12 individuals positive for autoantibodies but without arthritis (RA-risk group) and 7 healthy controls underwent ultrasound-guided inguinal lymph node biopsy. Frequencies of ILCs subsets as well as the expression of VCAM and ICAM by lymph node endothelial cells and fibroblasts were analysed by flow cytometry. <h3>Results</h3> Although no difference in the number of total ILCs (Lin<sup>-</sup>CD45<sup>+</sup><sup>/low</sup>CD127<sup>+</sup>) was found among the three study groups, the distribution of the different ILC populations changed. RA patients showed a relative lower frequency of LTi (c-Kit<sup>+</sup>NKp44<sup>-</sup> ILCs) and an increased frequency of ILC1 (c-Kit<sup>-</sup>NKp44<sup>-</sup> ILCs) and ILC3 (c-Kit<sup>+</sup>NKp44<sup>+</sup> ILCs) populations compared with controls (p &lt; 0.001, p &lt; 0.05 and p &lt; 0.05, respectively). RA-risk individuals showed a relative increased frequency of inflammatory ILC1 compared with controls (p &lt; 0.01). Frequencies of LTi correlated with the expression of adhesion molecules on endothelial and fibroblastic cells. <h3>Conclusions</h3> Already during the earliest phases of systemic autoimmunity, the ILC distribution in lymph nodes changes from a homeostatic towards a more inflammatory profile, thereby supporting a role for ILCs in the pathogenesis of RA.
Senate Votes on Airline Smoking Ban
Authors: T. Hensley
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Senate Votes on Airline Smoking Ban Get access Tim Hensley Tim Hensley Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 20, 18 October 1989, Page 1532, https://doi.org/10.1093/jnci/81.20.1532 Published: 18 October 1989
DETERMINANTS OF IN-HOSPITAL MORTALITY IN CARDIAC ARREST PATIENTS PRESENTING FOR EMERGENT CORONARY ANGIOGRAPHY
Authors: Smita Negi, Nirav Patel, Anil Kumar Jonnalagadda, Sarkis Kiramijyan, Edward Koifman, Arie Steinvil, Toby Rogers, Rebecca Torguson, Itsik Ben-Dor, William Suddath, Augusto Pichard, Lowell Satler, Ron Waksman
Journal: Journal of the American College of Cardiology (2016)
Uptake of Ammonia by Muscle
Authors: Samuel P. Bessman, J. Edmund Bradley
Journal: New England Journal of Medicine (1955)

AN elevated blood anemia content has been reported to be a feature of hepatic coma by a number of laboratories,1 2 3 4 but high levels have not always been found in this syndrome. Observations made during the course of an investigation of the cerebral uptake of ammonia5 , 6 suggested that the finding of a normal venous ammonia level in hepatic coma might well be due to an uptake of ammonia by muscle. The following data show that this is indeed so, and that in the presence of a significantly increased arterial ammonia level the muscle can remove an amount of ammonia sufficient to . . .
Abstract 3537: Serum cobalamin level and clinical outcome in patients with acute myeloid leukemia.
Authors: Li-Yuan Bai, Tzu-Ting Chen, Long-Yuan Li, Chang-Fang Chiu
Journal: Cancer Research (2013)

Abstract Introduction: An elevated concentration of serum cobalamin was found in one third of patients with acute myeloid leukemia; however, the clinical implication of elevated level of cobalamin in disease prognosis is not clear. Procedures: We performed a retrospective analysis of the patients who were diagnosed to have de novo acute myeloid leukemia at China Medical University Hospital from January 2003 to December 2011. Two hundred and six patients were diagnosed as de novo acute myeloid leukemia, and thirty-four patients (16.5%) had been checked the level of serum cobalamin at diagnosis. Patients were divided into two groups, one with serum cobalamin level less than 400 pg/mL (n=10), the other with serum cobalamin level 400 pg/mL or higher (n=24). The clinical and cytogenetic characteristics between each group were compared. Findings: There was no difference in gender, age and cytogenetic risk between the two groups. Nine of ten patients in lower serum cobalamin group and eighteen of twenty-four patients in higher serum cobalamin group received intensive chemotherapy for acute myeloid leukemia (p=0.315). The patients with lower serum cobalamin had a trend to obtain complete remission (80.0 % vs. 45.8 %, p=0.072). For patients who reached complete remission after chemotherapy, those in the higher cobalamin group had a trend to have more disease relapse (81.8% vs. 37.5%, p=0.067). Interestingly, the relapse-free survival time after complete remission was 42.5 m and 9.2 m for patients with lower and higher cobalamin, respectively (p=0.010). Furthermore, serum cobalamin level remained significant in the multivariate analysis of risk factors for relapse-free survival (p=0.028). The median overall survival time was 18.3 m and 7.2 m for patients with lower and higher cobalamin, respectively. However, the difference in overall survival between the two groups did not reach statistical significance (p=0.140). In multivariate analysis, intensive chemotherapy for AML was the most important factor for overall survival. Conclusions: AML patients with higher serum level of cobalamin have a trend of worse response to chemotherapy, higher relapse rate and significantly shorter relapse-free survival time. Targeted therapy to interfere the cobalamin uptake or related pathways is worth of further investigation in treating patient with acute myeloid leukemia. Citation Format: Li-Yuan Bai, Tzu-Ting Chen, Long-Yuan Li, Chang-Fang Chiu. Serum cobalamin level and clinical outcome in patients with acute myeloid leukemia. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3537. doi:10.1158/1538-7445.AM2013-3537