tbuckley/cabot-search huggingface dataset:
AB0840 Scleroderma classification criteria: Disease-specific methods for valid case comparisons
Authors: S.R. Johnson, R.L. Naden, J. Fransen, F. van den Hoogen, J.E. Pope, M. Baron, M. Matucci-Cerinic, A. Tyndall, O. Distler, C. Denton, A. Gabrielli, J. van Laar, M. Mayes, V. Steen, J. Seibold, P. Clements, T. Medsger, P. Carreira, G. Riemekasten, D. Khanna
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Classification criteria for systemic sclerosis (SSc) are being developed. Twenty-three candidate criteria have been identified and validated. Standardized cases need to be developed for criteria reduction and possible weighting. <h3>Objectives</h3> To develop and test SSc-specific case forms for clarity and feasibility. We secondarily explored the agreement between SSc experts on the probability that cases were classified as SSc. <h3>Methods</h3> Standardized forms were developed using: skin thickening; nailfold capillary pattern; finger tip ulcers/pitting scars; Raynaud's phenomenon; interstitial lung disease; renal crisis; reduced DLCO; reduced FVC; dysphagia, esophageal dilation; telangiectasia; flexion contractures; pulmonary hypertension; puffy fingers; pulp loss/acro-osteolysis; gastroesophageal reflux; calcinosis; tendon/bursal friction rubs; topoisomerase-I, centromere, RNA polymerase III, antinuclear or PM-ScL antibodies. Six experts tested 6 cases and the ranking procedure for clarity of the instructions, response option and time-to-completion. The forms were applied to purposively sampled SSc cases from international cohorts covering a wide range of probabilities that each case had SSc. Eight experts rank-ordered 20 cases from 1 (highest) to 20 (lowest). The consistency in rankings was evaluated using an intraclass correlation coefficient (ICC). <h3>Results</h3> 83% (5/6) endorsed clarity of the form, 100% (6/6) clarity of the instructions, and 100% (6/6) clarity of the response option. The median time-to-completion was 10 minutes (range 10–20). The ICC for agreement across experts was 0.73 (95% CI 0.58, 0.86). <h3>Conclusions</h3> Our SSc-specific forms have demonstrable clarity and feasibility. Using these cases, the expert panel had substantial agreement in rank order. Our methods reflect the rigors of modern psychometric science, and serves as a template for groups developing classification criteria. <h3>Disclosure of Interest</h3> None Declared
Abstract 4433: DW-MR imaging as a predictive biomarker of radiosensitization of GBM through targeted inhibition of checkpoint kinases.
Authors: Terence Williams, Stefanie Galbán, Fei Li, Kevin Heist, Craig Galbán, Theodore S. Lawrence, Eric C. Holland, Tami Thomae, Thomas Chenevert, Alnawaz Rehemtulla, Brian D. Ross
Journal: Cancer Research (2013)

Abstract Purpose: The inherent treatment resistance of glioblastoma (GBM) can involve multiple mechanisms including checkpoint kinase (Chk1/2) mediated increased DNA repair capability which can attenuate the effects of genotoxic chemotherapies and radiation. The goal of this study was to evaluate DW-MRI as a biomarker for Chk1/2 inhibitors in combination with radiation for enhancement of treatment efficacy in GBM. Experimental Design: We evaluated a specific small molecule inhibitor of Chk1/2, AZD7762, in combination with radiation using in vitro human cell lines and in vivo using a genetically engineered GBM mouse model. Diffusion-weighted and T1-contrast MRI were used to follow treatment effects on intracranial tumor cellularity and growth rates, respectively. Results: AZD7762 inhibited clonal proliferation in a panel of GBM cell lines and increased radiosensitivity in p53-mutated GBM cell lines to a greater extent compared to p53-wild type cells. In vivo efficacy of AZD7762 demonstrated a dose-dependent inhibitory effect on GBM tumor growth rate and a reduction in tumor cellularity based on DW-MRI scans along with enhancement of radiation efficacy. Conclusion: DW-MRI was found to be a useful imaging biomarker for the detection of radiosensitization through inhibition of checkpoint kinases. Chk1/2 inhibition resulted in antiproliferative activity, prevention of DNA-damage induced repair, and radiosensitization in preclinical GBM tumor models, both in vitro and in vivo. The effects were found to be maximal in p53-mutated GBM cells. These results provide the rationale for integration of DW-MRI in clinical translation of Chk1/2 inhibition with radiation for the treatment of GBM. Citation Format: Terence Williams, Stefanie Galbán, Fei Li, Kevin Heist, Craig Galbán, Theodore S. Lawrence, Eric C. Holland, Tami Thomae, Thomas Chenevert, Alnawaz Rehemtulla, Brian D. Ross. DW-MR imaging as a predictive biomarker of radiosensitization of GBM through targeted inhibition of checkpoint kinases. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4433. doi:10.1158/1538-7445.AM2013-4433
18F-FDG PET/CT Imaging of Critical Ischemia in the Diabetic Foot
Authors: Fanny Marre, Louis Sibille, Enrique Nalda, Pierre-Olivier Kotzki, Vincent Boudousq
Journal: Clinical Nuclear Medicine (2013)

A 72-year-old patient with type 2 diabetes mellitus underwent F-FDG PET/CT for diabetic foot infection. No increased focal uptake was seen. F-FDG uptake was absent in the second, third, and fourth toes of the right foot. Angiography demonstrated severe stenosis in the proximal anterior tibial artery and segmental stenosis on the posterior tibial artery. The patient was diagnosed as having dry gangrene of the second to fourth toes of the right foot due to ischemia. He underwent a selective amputation because of the lack of revascularization possibilities.
Tl-201 Uptake in Bone and Soft Tissue Involvement of Sarcoidosis
Authors: BERNA DEGIRMENCI, AYSE MAVI, SERMIN ÖZKAL, OYA ITIL, HASAN HAVITCIOGLU, DINC ÖZAKSOY, MUSTAFA YILMAZ, GAMZE CAPA KAYA
Journal: Clinical Nuclear Medicine (2001)

The authors describe a 38-year-old man who was referred to the nuclear medicine department because of pain and swelling of his fingers in both hands. Tc-99m MDP and Tl-201 scans were performed to evaluate the lesions. A Tc-99m MDP bone scan showed hyperemia and increased uptake in the lesions. A Tl-201 scan showed marked uptake in both early and delayed images in the lesions of his fingers. Bone biopsy and histologic examination confirmed sarcoidosis. This case indicates that Tl-201 uptake can be seen in bone lesions resulting from sarcoidosis.
Pharmacogenetics of organic anion transporting peptides (OATP): An association of a SLCO1B3 polymorphism with the overall survival in white Caucasian patients with androgen independent prostate cancer
Authors: A. Hamada, D. K. Price, T. Sissung, D. Venzon, W. L. Duhut, W. D. Figg
Journal: Journal of Clinical Oncology (2007)

5118 Background: Steroid hormone have been implicated in playing a fundamental role in pathogenesis of prostate cancer and several studies have reported an association between clinical outcome and polymorphism of genes involved in steroid metabolism. Recently we observed that polymorphic enzyme CYP17 which influences the rate-limiting steps in androgen biosynthesis was associated with overall survival. However, the effect of genetic variation on the transport of steroid hormones remains unknown. The purpose of this study was to evaluate the association between clinical outcomes in patients with androgen independent prostate cancer, and polymorphism in the SLCO1B3 gene that are potentially important in the differential uptake of steroid hormones. Methods: One hundred seventy nine white Caucasian patients with androgen independent prostate cancer were enrolled in this study. The duration of survival was computed from the date of prostate cancer diagnosis until the date of death or last follow-up. The SLCO1B3 polymorphism (-334 T&gt;G) was analyzed using an automated sequencer. Results: The T allele (TT or TG) and G allele (GG) frequency of SLCO1B3 among all patients was 0.16 and 0.84, respectively. The frequency of the SLCO1B3 genotype was similar in patients and healthy volunteer. No significant differences were observed in the frequencies of the SLCO1B3 genotype in relation to categorized Gleason scores and age at diagnosis. Interestingly, the median survival was significantly longer in 134 patients with the SLCO1B3 G allele (8.4 years) genotype than 45 patients carrying at least one T allele (6.4 years) genotype (hazard ratio=1.58, 95%CI: 1.13 - 2.26, p=0.0105 by Logrank test). Similarly, the survival probability at ten years (22.9% in T allele vs 41.1% in G allele) is observed. Conclusions: Our results indicate that the SLCO1B3 polymorphism is associated with overall survival in white Caucasian patients with androgen independent prostate cancer. Large population-based studies are needed to confirm these results. No significant financial relationships to disclose.
Regulation of chronic inflammatory and immune processes by extracellular vesicles
Authors: Paul D. Robbins, Akaitz Dorronsoro, Cori N. Booker
Journal: Journal of Clinical Investigation (2016)

Almost all cell types release extracellular vesicles (EVs), which are derived either from multivesicular bodies or from the plasma membrane. EVs contain a subset of proteins, lipids, and nucleic acids from the cell from which they are derived. EV factors, particularly small RNAs such as miRNAs, likely play important roles in cell-to-cell communication both locally and systemically. Most of the functions associated with EVs are in the regulation of immune responses to pathogens and cancer, as well as in regulating autoimmunity. This Review will focus on the different modes of immune regulation, both direct and indirect, by EVs. The therapeutic utility of EVs for the regulation of immune responses will also be discussed.
AB1121 The Forgotten Joint Score, A New Questionnaire to Evaluate Patient's Perception of Total Knee and Hip Arthroplasty in Patients with Established Rheumatoid Arthritis
Authors: E. Azzi, E. Thienpont, M. Avaux, F.A. Houssiau, P. Durez
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The "Forgotten Joint" score has been recently developed as a patient reported outcome in hip and/or knee total joint arthroplasty (TJA). This questionnaire analyses patient9s perception to forget the artificial joint in everyday life. In patient with osteoarthritis, this new score showed a low ceiling effect, a high internal consistency and could discriminate patient groups with different outcomes. Since TJA is frequently performed and effective in severe rheumatoid arthritis (RA), the purpose of this study is to test the "Forgotten Joint" score (FJS-12) in this population. <h3>Methods</h3> Between June and September 2013, RA patients who underwent TJA more than one year ago were asked to fill in the FJS-12 questionnaire during their routine visit. Data collected included the ACR/EULAR core set parameters, a pain VAS scale for the TJA, HAQ-DI, SF36 and HAD questionnaires in French. The range of the FJS-12 is 0 to 100, high scores indicate good outcome, that is, a high degree of forgetting the joint. <h3>Results</h3> 49 patients (46 women and 3 men) with 74 TJA (48 TKA, 26 THA) were included The mean patient age was 54.4 years (range 32-75 years) with a mean disease duration of 15.3 years, a mean DAS28-CRP of 2.95, a mean HAQ-DI of 1.38, a mean mental health SF36 score of 48.4 and a mean physical health SF36 score of 36.6. The mean follow-up of the prothesis was 9.4 years. The mean FJS-12 in all TJA was 75.6 with a score of 72.9 for TKA and 80.8 for THA. The average pain VAS score was 14.78 (0-100). <h3>Conclusions</h3> The Forgotten Joint score is an useful questionnaire to evaluate joint arthroplasty in RA. Patients with established RA were highly satisfied from their arthroplasty and yielded a high ability to forget their artificial joint despite a severe and longlasting disease. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4496
NI-56 * FET-PET ADDS PREDICTIVE VALUE TO LOCALIZATION OF TREATMENT FAILURE IN HIGH GRADE GLIOMAS
Authors: M. Lundemann, J. Costa, I. Law, S. A. Engelholm
Journal: Neuro-Oncology (2014)

PURPOSE: To evaluate if post-surgical magnetic resonance imaging (MRI) in combination with positron emission tomography (PET) is a better predictor for localization of treatment failure than MRI alone in patients with high grade gliomas. METHODS: Twenty-one patients with primary glioblastoma WHO grade IV were included in this retrospective study. Post-surgical, contrast-enhanced MRI was used to define the gross tumor volume (GTV-MR). In addition, 18F-fluoro-ethyltyrosine (FET) PET was performed, and the FET-positive volume was semi-automatically determined by including tissue with an uptake exceeding 1.6 times the uptake in normal appearing gray matter, and subsequently manually edited to exclude non-tumor. We defined GTV-MR in combination with FET as GTV-MRPET. Clinical target volume (CTV) was defined by adding a two centimeter margin to GTV-MR and modified to include the FET-volume. Patients were treated with surgery and subsequent chemo-radiation (RCX) to 60 Gy in 30 fractions to the CTV plus concurrent and adjuvant temozolomide (TMZ). Treatment failure volume (TFV) was defined as the earliest radiological evidence of residual or recurrent disease on post-therapeutic MRI. The maximum distances from GTV-MR and GTV-MRPET to encompass TFV, and the sensitivity as well as specificity between TV and TFV, were calculated and pairwise compared (Wilcoxon). RESULTS: The maximum distance to encompass TFV was significantly higher (p < 0.001) for GTV-MR (12.7 mm [3.20-73.6]) compared to GTV-MRPET (11.4 mm [3.15-73.6]). GTV-MRPET was significantly more sensitive in predicting the location of TFV (p < 0.001), however the specificity was significantly lower (p < 0.001). CONCLUSION: GTV-MRPET required smaller margin to encompass the TFV, was more sensitive but less specific than GTV-MR.
Prader–Willi Syndrome and Angelman Syndrome in Cousins from a Family with a Translocation between Chromosomes 6 and 15
Authors: Dominique F.C.M. Smeets, Ben C.J. Hamel, Marcel R. Nelen, Hubertus J.M. Smeets, Josephus H.M. Bollen, Arie P.T. Smits, Hans-Hilger Ropers, Bernard A. van Oost
Journal: New England Journal of Medicine (1992)

PRADER—WILLI syndrome represents the most common form of genetic obesity and is associated with mental retardation, short stature, sexual infantilism, and hypotonia1 2 3 4 5 6 (Table 1). In about 60 percent of affected persons a microscopically visible interstitial deletion in chromosome 15 (band ql2) is observed,2 , 3 , 7 8 9 10 and in up to 75 percent deletions can be found at the molecular level.11 122 13 14 DNA studies with polymorphic markers have indicated that in Prader-Willi syndrome the aberrant chromosome 15 is always of paternal origin,11 , 12 suggesting that the two parental chromosomes are differently imprinte1515 and that the presence of a gene or genes on the paternally . . .
AB0654 Diagnostic value of blood B-cell subset profiling for primary sjÖgren’s syndrome
Authors: D. Cornec, A. Saraux, J.-O. Pers, S. Jousse-Joulin, T. Marhadour, P. Youinou, V. Devauchelle-Pensec
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Primary Sjögren's syndrome (pSS) is a systemic auto-immune disease, characterised by abnormalities of B cell homeostasis. Several studies demonstrated that the repartition of blood B cell subsets is altered during pSS. <h3>Objectives</h3> The aim of this prospective study was to determine the diagnostic value of blood B-cell subset profiling for pSS. <h3>Methods</h3> This cross-sectional study was conducted in a monocentric cohort of patients with suspected pSS prospectively included between November 2006 and April 2011. Clinical examination, basic biology, immunological tests and minor labial salivary gland biopsy were performed systematically. For blood B-cell subset profiling, the ratio (Bm2+Bm2')/(eBm5+Bm5) was determined using flow cytometry. The gold standard for the analysis was a clinical diagnosis of pSS performed by a group of experts, blinded to the results of B-cell profiling. <h3>Results</h3> 170 patients have been included in the study. 72 patients had pSS, of whom 58 (80.6%) fulfilled AECG criteria. No differences were found between the 2 groups concerning age, disease duration, and sex ratio. All items of AECG criteria were significantly associated with the diagnosis of pSS except xerostomy. The mean (Bm2+Bm2')/(eBm5+Bm5) ratio was significantly higher in the pSS group than in the non-pSS group (7.2±7.0 vs. 3.2±2.4, P&lt;0.001). By ROC curve analysis ≥5 was the best cut-off, with 51.4% sensitivity, 82.7% specificity, 68.5% positive predictive value, and 67.9% negative predictive value (figure). High values of this ratio strongly suggested pSS diagnosis. Thus, a cut-off of 6.5 increased Sp to 92.9% and PPV to 80.6% and a cut-off of 9 provided 98% Sp and 90.5% PPV (with 40.3% and 26.4% Se, respectively). Among the 17 non-pSS patients who had a ratio ≥5, 8 had idiopathic sicca, 5 had secondary SS, and 4 had drug-induced sicca. <h3>Conclusions</h3> Blood B cell profiling using flow cytometry is a simple test that displays good diagnostic properties for pSS. Its inclusion into diagnostic criteria should be evaluated. <h3>Disclosure of Interest</h3> None Declared
A Comparison of Nefazodone, the Cognitive Behavioral-Analysis System of Psychotherapy, and Their Combination for the Treatment of Chronic Depression
Authors: Martin B. Keller, James P. McCullough, Daniel N. Klein, Bruce Arnow, David L. Dunner, Alan J. Gelenberg, John C. Markowitz, Charles B. Nemeroff, James M. Russell, Michael E. Thase, Madhukar H. Trivedi, Janice A. Blalock, Frances E. Borian, Darlene N. Jody, Charles DeBattista, Lorrin M. Koran, Alan F. Schatzberg, Jan Fawcett, Robert M.A. Hirschfeld, Gabor Keitner, Ivan Miller, James H. Kocsis, Susan G. Kornstein, Rachel Manber, Philip T. Ninan, Barbara Rothbaum, A. John Rush, Dina Vivian, John Zajecka
Journal: New England Journal of Medicine (2000)

Patients with chronic forms of major depression are difficult to treat, and the relative efficacy of medications and psychotherapy is uncertain.
Watchdog uncovers "a culture of abuse" at Essex hospital
Authors: C. Dyer
Journal: BMJ (2011)

<h3>Rationale</h3> The diffusing capacity of the lung for carbon monoxide corrected for haemoglobin (<i>D</i><sub>LCOcor</sub>) measures gas movement across the alveolar–capillary interface. We hypothesised that <i>D</i><sub>LCOcor</sub> is a sensitive measure of injurious allograft processes disrupting this interface. <h3>Objectives</h3> To determine the prognostic significance of the <i>D</i><sub>LCOcor</sub> trajectory on chronic lung allograft dysfunction (CLAD) and survival. <h3>Methods</h3> A retrospective analysis was conducted of all bilateral lung transplant recipients at a single centre, between January 1998 and January 2018, with one or more <i>D</i><sub>LCOcor</sub> measurements. Low baseline <i>D</i><sub>LCOcor</sub> was defined as the failure to achieve a <i>D</i><sub>LCOcor</sub> &gt;75% predicted. Drops in <i>D</i><sub>LCOcor</sub> were defined as &gt;15% below recent baseline. <h3>Results</h3> 1259 out of 1492 lung transplant recipients were included. The median (range) time to peak <i>D</i><sub>LCOcor</sub> was 354 (181–737) days and the mean±sd<i>D</i><sub>LCOcor</sub> was 80.2±21.2% pred. Multivariable analysis demonstrated that low baseline <i>D</i><sub>LCOcor</sub> was significantly associated with death (hazrd ratio (HR) 1.68, 95% CI 1.27–2.20; p&lt;0.001). Low baseline <i>D</i><sub>LCOcor</sub> was not independently associated with CLAD after adjustment for low baseline forced expiratory volume in 1 s or forced vital capacity. Any <i>D</i><sub>LCOcor</sub> declines ≥15% were significantly associated with death, independent of concurrent spirometric decline. Lower percentage predicted <i>D</i><sub>LCOcor</sub> values at CLAD onset were associated with shorter post-CLAD survival (HR 0.75 per 10%-unit change, p&lt;0.01). <h3>Conclusion</h3> Low baseline <i>D</i><sub>LCOcor</sub> and post-transplant declines in <i>D</i><sub>LCOcor</sub> were significantly associated with survival, independent of spirometric measurements. We propose that <i>D</i><sub>LCOcor</sub> testing may allow identification of a subphenotype of baseline and chronic allograft dysfunction not captured by spirometry. There may be benefit in routine monitoring of <i>D</i><sub>LCOcor</sub> after lung transplantation to identify patients at risk of poor outcomes.
Cost Effectiveness of Early Discharge after Uncomplicated Acute Myocardial Infarction
Authors: L. Kristin Newby, Eric L. Eisenstein, Robert M. Califf, Trevor D. Thompson, Charlotte L. Nelson, Eric D. Peterson, Paul W. Armstrong, Frans Van de Werf, Harvey D. White, Eric J. Topol, Daniel B. Mark
Journal: New England Journal of Medicine (2000)

Reducing the length of hospitalizations can reduce short-term costs, but there are few data on the long-term clinical and economic consequences of early discharge after uncomplicated myocardial infarction.
Bone Marrow Metastases From Alveolar Rhabdomyosarcoma With Impressive FDG PET/CT Finding But Less-Revealing Bone Scintigraphy
Authors: Jigang Yang, Lishi Zhen, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2013)

An 18F-FDG PET/CT scan was performed in a 26-year-old man with a known alveolar rhabdomyosarcoma for staging. The PET/CT scan showed abnormally increased FDG activity involving almost all bones in the imaged regions. In contrast, 99mTc-MDP whole-body bone scan demonstrated only very limited bone metastases.