tbuckley/cabot-search huggingface dataset:
SUDDEN CARDIAC DEATH IN 21,105 PATIENTS WITH ATRIAL FIBRILLATION: INSIGHTS FROM THE ENGAGE AF- TIMI 48 TRIAL
Authors: Alon Eisen, Christian Ruff, Francesco Nordio, Ramon Corbalan, Anthony Dalby, Maria Dorobantu, Michele Mercuri, Hans Lanz, Howard Rutman, Elliott Antman, Eugene Braunwald, Robert Giugliano
Journal: Journal of the American College of Cardiology (2016)
AB0545 Tocilizumab improves BMD compared with abatacept in patients with TNF blockers-resiistant active RA
Authors: K. Kume, K. Amano, K. Hatta, H. Ohta
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To compare the effect of tocilizumab(TCZ) plus methotrexate (MTX), with the effect of abatacept(ABT) plus MTX on bone mineral density(BMD) in TNF blockers resistant active rheumatoid arthritis(RA; without osteoporosis) patients, in a prospective open label randomized study design. <h3>Methods</h3> RA patients were eligible if they had active disease despite treatment with MTX plus TNF blockers. All patients have no previous history of lumbar and hip fractures. Patients receiving or having received bisphosphonates or hormone replacement therapy, steroids, or any biologics were excluded. 28 patients with moderate to severe active RA patients (DAS28 &gt;3.2) were randomly assigned to receive TCZ plus MTX (n=14) or ABT plus MTX (n=14). All patients with worsening disease activity at week 12, the patients were allowed to escape to another group (by clinician's judgment). The primary outcomes were changes in lumbar and femoral BMD by dual-energy X-ray absorptiometry, secondary outcome were changes in biomarkers of bone turnover (procollagen type I amino-terminal propeptide(P1NP) from baseline to 52 weeks. Clinical data were collected at regular visit. All patients were taking calcium (1 g/day) and vitamin D (800 IU/day). <h3>Results</h3> The characteristics of each group at baseline were not significantly different. 11 each in the TCZ and ABT groups completed 24 weeks. Lumbar and femoral BMD were attenuated significantly by TCZ (weeks 52-baseline: lumbar BMD: 0.05±0.009 g/cm<sup>2</sup>, <i>p</i> &lt;0.001; femoral BMD: 0.03±0.004 g/cm<sup>2</sup>, <i>p</i> &lt;0.001).On the other hand, lumbar and femoral BMD were not attenuated significantly by ABT (weeks 52-baseline: lumbar BMD: 0.01±0.052 g/cm<sup>2</sup>, <i>p</i> =0.66; femoral BMD: -0.002±0.009 g/cm<sup>2</sup>, <i>p</i> =0.87. The change (weeks 52-baseline) lumbar and femoral BMD of the TCZ group were significantly improvement than those of the ABT group (TCZ vs. ABT, lumbar BMD: <i>p</i> &lt;0.05; femoral BMD: <i>p</i> &lt;0.05). P1NP was significant increase by TCZ (weeks 52-baseline: 4.0±0.13μg/L, p&lt;0.05), but was no significant change by ABT (weeks 52-baseline: 1.2. ±0.73μg/L, p=0.55). DAS28 and CRP improved significantly in both groups (weeks 52-baseline; DAS28, TCZ: -2.31±0.65, ABT: -2.55±0.52) (CRP, TCZ: -19.6±5.2 mg/l, ABT: -16.7±3.3mg/l) (<i>p</i>&lt;0.05). They were no significant difference between groups. <h3>Conclusions</h3> TCZ plus MTX improves bone mineral density compared with ABT plus MTX in TNF blockers resistant RA. If RA patients were resist TNF blocker, we might think the patients were treated by TCZ than ABT. <h3>Disclosure of Interest</h3> None Declared
Cytomegalovirus Retinitis in a Patient Who Received Ruxolitinib
Authors: Joanna von Hofsten, Marianne Johnsson Forsberg, Madeleine Zetterberg
Journal: New England Journal of Medicine (2016)

The Janus kinase 2 inhibitor ruxolitinib can produce defects in host defenses that may lead to opportunistic infections such as cytomegalovirus retinitis.
Efficacy of enhanced outreach counseling to reenroll high-risk drug users 1 year after discharge from treatment
Authors: D A Zanis, A T McLellan, A I Alterman, R A Cnaan
Journal: American Journal of Psychiatry (1996)

Because discharged methadone maintenance patients represent a population at particularly high public health risk, the authors studied such patients 1 year after their discharge from a methadone program.The locations of 94 of 110 discharged patients were successfully determined 1 year after discharge. Nine (10%) of these patients had died, 37 (39%) were already reenrolled in treatment, and 7 (7%) did not require treatment. The 41 remaining subjects were randomly assigned to either the enhanced outreach counseling condition (N = 27) or a standard referral condition (N = 14).Within 2 weeks following this intervention, 17 (63%) of the 27 patients in the enhanced outreach counseling program and one (7%) of the 14 patients not in the program had reenrolled in treatment.These data suggest that enhanced outreach counseling may be an effective outreach strategy as well as a risk-reduction for discharged methadone maintenance patients.
A Comparison of Standard-Dose and High-Dose Epinephrine in Cardiac Arrest outside the Hospital
Authors: Charles G. Brown, Daniel R. Martin, Paul E. Pepe, Harlan Stueven, Richard O. Cummins, Edgar Gonzalez, Michael Jastremski
Journal: New England Journal of Medicine (1992)

Experimental and uncontrolled clinical evidence suggests that intravenous epinephrine in doses higher than currently recommended may improve outcome after cardiac arrest. We conducted a prospective, multicenter study comparing standard-dose epinephrine with high-dose epinephrine in the management of cardiac arrest outside the hospital.
Familial Syndrome of Primary Testicular Insufficiency with Normal Virilization, Blindness, Deafness and Metabolic Abnormalities
Authors: Richard L. Weinstein, Bernard Kliman, Robert E. Scully
Journal: New England Journal of Medicine (1969)

In spite of the presence of small testes and elevated urinary gonadotropin levels, two brothers with a new syndrome of familial hypogonadism had normal secondary sex characteristics. Associated findings were blindness, deafness and several metabolic abnormalities, including hyperuricemia and elevated serum triglyceride and pre-beta-lipoprotein values. Testicular-biopsy specimens showed small hyalinized tubules and abundant Leydig cells. The plasma testosterone levels of both siblings were below the adult male range, but similar to those of adolescent males with established signs of masculinization. Chorionic gonadotropin in large doses did not raise the plasma testosterone level, suggesting decreased Leydig-cell reserve. This syndrome resembles that described by Alstrom and his co-workers, but is clearly distinguishable from other known types of familial hypogonadism.
OP0133 Analysis of Potential Predictors for Remission in Early Rheumatoid Arthritis According to ACR/EULAR Boolean, DAS28 and RAPID3RJ1 Criteria: Results from the Espoir Cohort
Authors: I. Castrejón, M. Dougados, B. Combe, F. Guillemin, B. Fautrel, T. Pincus
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Remission in rheumatoid arthritis (RA) is increasingly possible in recent years with a treat-to-target strategy. It would be of value to recognize baseline variables that are potential predictors of remission. <h3>Objectives</h3> To analyze baseline RA core data set and demographic variables as potential predictors of remission at 6 or 12 months in the ESPOIR usual care cohort of early RA. <h3>Methods</h3> The ESPOIR usual care cohort includes patients with early RA who had baseline DAS28 ≥5.1. Three remission criteria were studied: ACR/EULAR Boolean – most stringent "gold standard" [1]; DAS28 ≤2.6 – predictors of remission in early RA have been reported [2]; and RAPID3RJ1 (RAPID3 ≤3 and ≤1 swollen joint) – similar results to the Boolean criteria [3]. Baseline variables were compared according to remission status 6 or 12 months later for each of 3 criteria, using univariate and multivariate regression models. <h3>Results</h3> 664 patients had available data. Remission at either 6 or 12 months was seen in 165 patients (24.8%) by Boolean criteria, 339 (51.4%) by DAS28, and 209 (31.5%) by RAPID3RJ1. Age and tender joint count were associated independently with remission by all 3 criteria in multivariate analyses (Table). Female gender, family history of RA, patient and physician global estimates, physical function, swollen joint counts and ESR were predictive in some models, although odds ratios were not substantial. Disease duration, radiographic erosions, CRP, anti-CCP and rheumatoid factor were not significant to predict remission by any of the 3 criteria, and therefore not entered into any multivariate models. <h3>Conclusions</h3> Younger age and lower initial number of tender joints were significant, while erosions, CRP, anti-CCP and rheumatoid factor were not significant to predict RA remission 6 or 12 months later according to any of the 3 criteria. <h3>References</h3> Felson DT, Smolen JS, Wells G, et al. Arthritis Rheum 2011;63:573-86. Ma MH, Ibrahim F, Walker D, et al. J Rheumatol 2012;39:470-5. Castrejón I, Dougados M, Combe B, et al. J Rheumatol 2013; in press. <h3>Disclosure of Interest</h3> None Declared
COMBINED ANGIOGRAPHY AND COMPUTED TOMOGRAPHY SYSTEM AS A NOVEL IMAGING MODALITY TO IMPROVE ANTEGRADE REVASCULARIZATION OF CHRONIC TOTAL OCCLUSIONS
Authors: Patrick T. Siegrist, Satoru Sumitsuji, Kensuke Yokoi, Youssef Kamel, Masaki Awata, Keita Yamasaki, Koichi Tachibana, Osamu Yamaguchi, Yasushi Sakata
Journal: Journal of the American College of Cardiology (2016)
Steroids to Prevent Uremia
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1979)

Each year in this country, 8000 to 10,000 people enter the terminal stages of chronic renal disease. Most have some form of primary glomerulopathy, by which I mean idiopathic glomerular injury that is not part of a systemic disease. Early in the course of the primary glomerulopathies, before scarring and atrophy begin to blur histologic distinctions, renal biopsy reveals several kinds of glomerular lesions, probably reflecting different pathogenic entities.Regardless of the underlying lesion, the universal hallmark of the glomerulopathies is proteinuria, which often becomes severe enough to cause the nephrotic syndrome. Among adult patients with the nephrotic syndrome the . . .
AB0544 Clinical, Biological and Morphological Features of Mucocutaneaous Manifestations in Primary SjÖGren's Syndrome: about 9 Cases
Authors: R. Hajji, C. Eya, D. Fatma, B.H. Lamia, K. Chakib
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Primary Sjögren9s syndrome (pSS) is a systemic disease marked by the dysfunction and destruction of exocrineglands due to lymphocytic infiltration. pSS patients may develop a large number of systemic manifestations. Mucocutaneousmanifestations are one of the most typical extraglandular features of pSS. A wide spectrum cutaneous lesions, includingleucocytoclastic vasculitis, mononuclear vasculitis, urticarial vasculitis, alopecia, non-specific photosensitive cutaneous lesions,vitiligo, cutaneous amyloidosis, annular granuloma, erythema multiforme have been reported in pSS patients. <h3>Objectives</h3> The aim of this work is to study the demographic, clinical, serologic features and outcomes of Tunisian patients withpSS and mucocutaneaous involvement. <h3>Methods</h3> It is a single-center retrospective study including all the cases of pSS diagnosed since 1998 until 2011 in InternalMedicine Department from Tunis in Tunisia. All the patients fulfilled the 2002 American-European Consensus Group (AECG)criteria for pSS <h3>Results</h3> The study include 31 patients: 4 men and 27 women. The age average was 51 years. Dryness of the mouth and eyes wasobserved in all the cases. Among them, 10 patients presented mucocutaneous manifestations: purpura in 7 cases, erythema multiformein 2 cases associated with livedo in one of them and one case of severe skin dryness.In the cases of the purpura, the skin biopsy have revealed leucocytoclastic vasculitis. There was no other disease associated with pSS.One patient with leucocytoclastic vasculitis have developed sensory axonal neuropathy. In the patient with erythema multiforme andlivedo, the mucosa-associated lymphoid tissue (MALT) lymphoma of the parotids was diagnosed.A diffuse dry itchy skin especially in the lower limbs was observed in a patient. The skin biopsy showed the presence of a lymphochronic inflammatory infiltrate organized in nodules around the excretory canals of the sweat glands of the skin. A hypohidrosis hasbeen diagnosed. <h3>Conclusions</h3> During the pSS, the most common clinical manifestation is mouth and eyes dryness. But extraglandularmanifestations are frequent. Skin involvement is one of the most typical systemic features of pSS often underestimated. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4700
SAT0235 Prevalence of Inflammatory Lesions MRI-SPINE in Patients with Chronic Back Pain of &lt;2 Years Duration Included in the Space-Cohort
Authors: M. De Hooge, R. Van Den Berg, M. Reijnierse, M. V. Navarro Compán, F. van Gaalen, K. M. Fagerli, M. Turina, M. van Oosterhout, R. Ramonda, T. Huizinga, D. Van Der Heijde
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Inflammatory lesions of the spine are not included in the ASAS definition of a positive MRI for fulfilment of the ASAS axial spondyloarthritis (axSpA) criteria<sup>1</sup>. However, inflammatory lesions in the spine on MRI (MRI-spine) may occur in the absence of affected sacroiliac joints (SIJ). <h3>Objectives</h3> To determine the prevalence of inflammatory lesions on MRI-spine and to investigate if axSpA patients (pts) with inflammatory lesions in the spine only exist. <h3>Methods</h3> The SPondyloArthritis Caught Early (SPACE)-cohort includes pts with chronic back pain (≥3 months, ≤2 years, onset &lt;45 years) recruited from 5 participating centres. All pts underwent MRI of the SIJ (MRI-SI) and MRI-spine scored by 3 well-calibrated readers independently. MRIs-SI were scored according to the ASAS definition<sup>1</sup> (≥1 lesion on ≥2 consecutive slices or &gt;1 lesion on 1 slice). Inflammatory lesions on MRI-spine suggestive of spondylitis were scored when visible on ≥2 consecutive slices and according to the ASAS consensus definition<sup>2</sup> (≥3 lesions on ≥2 consecutive slices). Lesions were considered present if 2/3 readers agreed. <h3>Results</h3> All pts with MRI-spine (n=306) were included to determine the prevalence of BME lesions in pts grouped according to the ASAS axSpA criteria (radiographic, non-radiographic (imaging &amp; clinical arm), no-SpA and possible SpA (table 1). 292 pts had both MRI-SI and MRI-spine. There were 51 pts with a positive MRI-spine, of which 30 pts (58.8%) had a negative MRI-SI. Nine of these 30 fulfil the ASAS axSpA criteria via the clinical-arm. Of the remaining 21 pts, 3 pts had no SpA features at all, 7 had 1 SpA feature, 8 had 2 SpA features, 1 had 3 SpA features and 2 had 4 SpA features. Only the sole patient with 4 SpA features had a probability (calculated from the Likelihood Ratio (LR) product) &gt;80%. When using the ASAS consensus definition of a positive MRI-spine in post-test probability calculations, another 6 pts would reach a probability ≥80% of having axSpA. <h3>Conclusions</h3> A cut-off of ≥3 BME lesions discriminates well between pts with and without axSpA. A positive MRI-spine can be present in pts without inflammation on MRI-SI. MRI-spine might have additional value to MRI-SI in a group of pts with a certain level of suspicion of axSpA. <h3>References</h3> Rudwaleit ARD 2009;68:1520-7 Hermann ARD 2012;71:1278-88 <h3>Disclosure of Interest</h3> None Declared
P92 CD161+ - T cells: defining their role in patients with and without chronic hepatitis C
Authors: N. Rajoriya, C. Willberg, B. Seigal, None YuHoi Kang, J. Phillips-Hughes, J. Collier, E. Barnes, R. Thimme, P. Klenerman
Journal: Gut (2011)

<h3>Introduction</h3> γ-δ T cells have been found in blood/liver of patients infected with hepatitis C (HCV). CD161+ is a C-type lectin found on the surface of T cells in humans. HCV specific T-cells have been found to express CD161 with enrichment within the liver. The role &amp; function of CD161+ γ-δ cells has not been established in HCV. <h3>Aim</h3> To explore the phenotype and function of CD161+ γ-δ T cells in humans, and to assess the impact on these cells of HCV infection. <h3>Method</h3> Whole blood/Peripheral Blood Mononuclear cell (PBMC) antibody staining with subsequent flow cytometry was performed to assess phenotype. Function was examined by Intracellular Cytokine staining (ICS). Intrahepatic lymhocytes (IHLs) were isolated from patients having liver biopsies for clinical indications with paired blood samples. Cord blood samples were used after ethical approval gained and consent from mothers. <h3>Results</h3> In healthy controls, the CD161 subset encompassed a mean of 82.1 (±12.8)% of γ-δ cells. The CD161 subset expressed more CXCR3/CCR6/IL-18R (p=0.03/0.01 and 0.03 respectively) than the CD161- subset. The CD161+ cells expressed significantly more If-y/TNF-α (p=0.001 respectively) than the negative subset, and more Granzyme A, B and K and perforin in keeping with a Th1 profile. 20% of γ-δ cells from cord blood samples expressed CD161, suggesting it is an innate feature but expanded throughout life. Whole blood γ-δ populations were significantly reduced in HCV compared to healthy donors (70% v 40%, p=0.0031), with the proportion of CD161+ γ-δ T-cells reduced in chronic HCV (82.1% vs 39%, p=0.006). The γ-δ cells in HCV expressed significantly more activation markers (CD38/CD69) and CXCR6 than in healthy controls irrespective of CD161 status. Of the CD161+ γ-δ cells, the predominant subset were Vδ2 in healthy controls blood however in HCV this was significantly reduced (p=0.0173) with the Vδ1 subset dominating. On isolation of IHLs (n=17: 8 HCV, 3 HBV and rest NAFLD/NASH), there was an enrichment of CD3+ γ-δ T-cells in liver tissue compared to blood irrespective of CD161 status. On sub-analysis there were no statistical differences between CD161 status of the γ-δ cell T-cells when comparing viral v non-viral aetiologies. <h3>Conclusion</h3> Our data suggests that HCV infection does directly reduce the γ-δ T-cell population in peripheral blood: mainly the CD161 subset. The virus also causes a reversal in the CD161 γ-δ T-cell population from Vδ2 to Vδ1 in the periphery, however it appears the enrichment of γ-δ T cells to the liver is not specific to CD161+ cells or to HCV infection. The CD161 phenotype present at birth but expanded throughout life. The CD161 subset appears to display a more Th1 profile and unlike their CD8 CD161++ α-β counterparts, CD161 expression by γ-δ T-cells is not tightly linked to a Type-17 differentiation pathway.
Minorities Remain Underrepresented in Science and Medicine
Authors: F. X. Mahaney
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Minorities Remain Underrepresented in Science and Medicine Get access Francis X. Mahaney, Jr. Francis X. Mahaney, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 2, 19 January 1994, Pages 83–84, https://doi.org/10.1093/jnci/86.2.83 Published: 19 January 1994
OP0193 Pyrin and PSTPIP1, Mutated in FMF, PAPA-, and PAMI Syndrome, are Involved in the Hypersecretion of Alarmins MRP8/14
Authors: S.K. Fassl, D. Holzinger, T. Vogl, M. Gattorno, A. Omenetti, J.J. Chae, I. Aksentijevich, J. Austermann, J. Roth
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Familial Mediterranean fever (FMF) and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome are inherited autoinflammatory diseases. FMF patients have mutations in pyrin, a protein that has been suggested to play a role in the regulation of the inflammasome, PAPA patients have mutations in PSTPIP1, which interacts with pyrin. In both diseases, extraordinarily elevated serum levels of MRP8/14 were detected. Recently, we have identified two novel autosomal dominant mutations in the <i>PSTPIP1</i> gene, p.E250K or p.E257K substitution, as genetic cause for a novel, more severe autoinflammatory entity: PAMI syndrome (PSTPIP1-associated myeloid-related-proteinaemia inflammatory syndrome). PAMI patients present with even higher levels of MRP8/14. MRP8 and MRP14 belong to the family of proinflammatory Damage Associated Molecular Pattern (DAMP) proteins, are mostly expressed in phagocytes and activate innate immune cells via TLR4 (Fassl et al. J. Immunol. 2015) after released via a so-called alternative pathway. However, the mechanism of secretion of MRP8/14 is still unknown. <h3>Objectives</h3> We investigated if pyrin and PSTPIP1 play a role in the secretion of MRP8/14. <h3>Methods</h3> MRP8/14 serum concentrations of patients were determined by ELISA. PSTPIP1 gene sequencing was performed in 14 patients with PAMI syndrome. Monocytes from patients were isolated and MRP8/14 levels were measured in culture supernatants prior and after activation. PSTPIP1-Pyrin-MRP8/14 interactions were investigated by immunoprecipitations and structural analysis. <h3>Results</h3> Monocytes from patients with PSTPIP1 mutations release significantly higher amounts of MRP8/14 than control cells. Immunoprecipitation studies demonstrated that p.E250K-PSTPIP1 is hyperphsphorylated and binds stronger to pyrin compared to wildtype protein. Furthermore, we could prove a direct interaction of both PSTPIP1 and pyrin with MRP8/14. By using deletion constructs of PSTPIP1 we could demonstrate that the MRP8/14 binding motif is mutated in PAMI syndrome. <h3>Conclusions</h3> Phagocytes seem to be the responsible cell type for the high serum concentration of MRP8/14 in PAMI syndrome. The DAMP proteins MRP8 and MRP14 interact directly with PSTPIP1 and mutations found in all patients are apparently located inside the PSTPIP1-MRP8/14 binding region. Moreover, the PSTPIP1 mutations influence the interaction with pyrin. Overall, our data indicate that hypersecretion of MRP8/14 is a relevant pathomechanism in PSTPIP1- and pyrin-associated diseases. <h3>Disclosure of Interest</h3> None declared
LP20 : Safety and efficacy of all-oral daa regimens in HIV-HCV coinfected cirrhotic patients from the prospective ANRS CO13 - HEPAVIH cohort
Authors: P. Sogni, C. Gilbert, K. Lacombe, L. Piroth, E. Rosenthal, S. Dominguez, J. Chas, D. Neau, I. Poizot-Martin, A. Gervais Hasenknopf, P. Morlat, A. Simon, D. Zucman, H. Aumaitre, C. Lascoux-Combe, L. Esterle, F. Dabis, L. Wittkop, D. Salmon-Ceron
Journal: Journal of Hepatology (2015)
Percutaneous Balloon Valvuloplasty for Pulmonic Stenosis in Adolescents and Adults
Authors: Chuan-Rong Chen, Tsung O. Cheng, Tao Huang, Ying-Ling Zhou, Ji-Yan Chen, Yi-Gao Huang, Hai-Jie Li
Journal: New England Journal of Medicine (1996)

Percutaneous balloon valvuloplasty has been the accepted first-line treatment for congenital pulmonic stenosis in children. Its efficacy in adolescents and adults is less well defined.
Diagnostic Approach of Rotor Syndrome With Cholescintigraphy
Authors: ANDREW M. FRETZAYAS, CHRIST S. STAVRINADIS, PETER M. KOUKOUTSAKIS, CONSTANTINE A. SINANIOTIS
Journal: Clinical Nuclear Medicine (1997)

Rotor syndrome is an inheritable disorder of bilirubin metabolism characterized by a chronic, benign, nonhemolytic jaundice, due to raised, predominantly direct bilirubin. It is considered a pathophysiologic entity primarily involving the storage of organic anions leading to increased reflux of bilirubin from the hepatocytes back to the plasma, resulting in decreased net hepatic uptake. This concept is further supported by scintigraphic findings(i.e., prolonged visualization of the cardiac blood pool with concomitant delayed and markedly decreased uptake of the radionuclide by the liver cells). Furthermore, this scintigraphic pattern differentiates Rotor syndrome from Dubin-Johnson syndrome, extrahepatic biliary obstruction, or advanced hepatocellular disease.