THE ANTIANEMIC FACTORS CONCERNED IN MACROCYTIC ANEMIAS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1952)

Editorial1 May 1952THE ANTIANEMIC FACTORS CONCERNED IN MACROCYTIC ANEMIASP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-36-5-1351 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe intensive investigations of the past two decades have not only revolutionized the treatment of the macrocytic anemias, but they have revealed the nature of some of the substances concerned in hemopoiesis and have given at least an indication of some of the biochemical reactions involved.1The function of these substances is by no means restricted to maintaining normal hemopoiesis. They are essential for the metabolism of all the body cells and indeed for the life and growth of all classes of living organisms. Much of what is known about them and even the practicable methods for their detection and...1 Girdwood RH: Analytical review: The interrelationships of factors that influence the megaloblastic anemias, Blood 7: 77-93, 1952. CrossrefMedlineGoogle Scholar2 Gardner FH: Observations on the etiologic relationship of achylia gastrica to pernicious anemia; hematopoietic activity in pernicious anemia of beef muscle extract containing food (extrinsic) factor upon intravenous injection without contact with gastric (intrinsic) factor, J. Lab. and Clin. Med. 34: 1502-1511, 1949. Google Scholar3 JukesStokstad THEL: Pteroylglutamic acid and related compounds, Physiol. Rev. 28: 51-106, 1948. CrossrefMedlineGoogle Scholar4 Welch AD: Ineffective utilization of pteroylglutamic (folic) acid in pernicious anemia, J. Biol. Chem. 164: 787, 1946. CrossrefMedlineGoogle Scholar5 Vilter RW: Studies on the relationships of vitamin B12, folic acid, thymine, uracil, and methyl group donors in persons with pernicious anemia and related megaloblastic anemias, Blood 5: 695-717, 1950. CrossrefMedlineGoogle Scholar6 Strauss MB: Vitamin B12 and pernicious anemia, New England J. Med. 243: 187, 1950. CrossrefMedlineGoogle Scholar7 Girdwood RH: Vitamin B12 and related factors. A clinical and experimental review, Edinburgh M. J. 57: 72-109, 1950. MedlineGoogle Scholar8 BerkCastle LWB: Observations on the etiologic relationship of achylia gastrica to pernicious anemia. X. Activity of vitamin B12 as food (extrinsic) factor, New England J. Med. 239: 911, 1948. CrossrefMedlineGoogle Scholar9 Girdwood RH: The intestinal content in pernicious anemia of factors for the growth of Streptococcus faecalis and Lactobacillus leichmanii , Blood 5: 1009-1016, 1950. CrossrefMedlineGoogle Scholar10 TernbergEakin JLRE: Erythein and apoerythein and their relation to the antipernicious anemia principle, J. Am. Chem. Soc. 71: 3858, 1949. CrossrefGoogle Scholar11 Ross GI: Vitamin B12 assay in body fluids, Nature 166: 270, 1950. CrossrefMedlineGoogle Scholar12 CallenderLajtha STLG: On the nature of Castle's hemopoietic factor, Blood 6: 1234-1239, 1951. CrossrefMedlineGoogle Scholar13 HorriganJarroldVilter DTRW: Direct action of vitamin B12 upon human bone marrow. The effect of instillation of vitamin B12 and folic acid into the bone marrow as studied by nucleic acid staining techniques, J. Clin. Investigation 30: 31-36, 1951. CrossrefMedlineGoogle Scholar14 Brink NG: Vitamin B12—identification as a cyano-cobalt co-ordination complex, Science 112: 354, 1950. CrossrefMedlineGoogle Scholar15 Glass GB: Relationship of glandular mucoprotein from human gastric juice to Castle's intrinsic antianemia factor, Science 115: 101-108, 1952. CrossrefMedlineGoogle Scholar16 Stokes JL: Substitution of thymine for "folic acid" in the nutrition of lactic acid bacteria, J. Bact. 48: 201, 1944. CrossrefMedlineGoogle Scholar17 Meyer LM: Studies in pernicious anemia patients treated with liver extract and folic acid antagonists, Am. J. M. Sc. 218: 197, 1949. CrossrefMedlineGoogle Scholar18 Ellison RR: Effect of citrovorum factor in pernicious anemia, Proc. Soc. Exper. Biol. and Med. 76: 366, 1951. CrossrefMedlineGoogle Scholar19 Owren PA: Is B12 the complete therapeutic answer in pernicious anemia? Proc. Internat. Soc. Hematology, Third Congress, Aug. 21-25, 1950-1951, Grune and Stratton, New York, p. 22-24. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1952Volume 36, Issue 5Page: 1351-1355KeywordsAnemiaCells ePublished: 1 December 2008 Issue Published: 1 May 1952 PDF downloadLoading ...