tbuckley/cabot-search huggingface dataset:
Preoperative chemotherapy prior to pulmonary metastatecomy in patients with prior surgically resected primary colorectal carcinoma.
Authors: Ishwaria Mohan Subbiah, Shanda H. Blackmon, Arlene M. Correa, Bryan K. Kee, Ara A. Vaporciyan, Stephen Swisher, Cathy Eng
Journal: Journal of Clinical Oncology (2013)

490 Background: The exact benefit of preoperative chemotherapy prior to pulmonary metastasectomy for patients with metastatic colorectal carcinoma (CRC) is unknown. Here, we identify outcomes of preop chemo in pts w previously resected primary CRC who then had resectable pulmonary CRC metastases. Methods: We queried a prospectively collected database to identify pts who underwent pulmonary CRC metastasectomy and the specific chemo regimen given prior to but w/i 3 months of surgery. Two multivariate logistic analyses were performed to identify preop regimen as predictors of overall survival (OS) and progression free survival (PFS). Results: From Feb 2000 onwards, 229 pts underwent lung met resection (median age 61, range 24-82). Of those pts, 114 received preop chemo for a median duration of 4months (range 0.1-25.3mos). 41pts receiving 0-3 mos of preop chemo, 37 3-6mos, and 36 &gt;6mos. 38pts received an oxaliplatin-based regimen (23 FOLFOX+bevacizumab [bev], 5 XELOX, 5 FOLFOX alone, 3 FOLFOX+cetuximab, 1 FOLFOX + novel TR-2/DR5 antibody, 1 oxali+irinotecan). 53 pts received an irinotecan-regimen. 29 received a capecitabine therapy. Pts on an oxali-based therapy had an improved OS vs alternate chemo regimen (mean OS 77.6 mos vs 54.2 mos, median OS not reached in oxali-group, p .001). However pts on an irinotecan-based regimen had a lower OS vs alternate chemo (median OS of 49.1mos vs 57.9mos, p .024). 5FU, capecitabine, or bev-based therapies did not significantly impact OS. The type of preop chemo regimen did not significantly affect PFS after lung met resection. Oxali-based regimen moved towards a favorable OS when compared to OS without any preop chemo but not of statistical significance (HR 0.69; 95% CI 0.287 to 1.663, p 0.409) while receiving a non-oxali-based preop regimen was associated with a shorter OS when compared to no preop chemo (HR 2.64; 95% CI 1.634 to 4.275, p &lt;0.001). Conclusions: Preop chemo with an oxaliplatin regimen prior to pulm met resection may improve OS, providing long-term benefit, whereas a preop irinotecan-based therapy appears to result in a shorter OS. Prospective trials on specific preop regimens and criteria for patient selection are planned.
Post-Transplant Cyclophosphamide and Bortezomib Combination for Prevention of GvHD after Allogeneic Blood and Marrow Transplantation Is Feasible and Produces Favorable Outcomes
Authors: A. Samer Al-Homsi, Tara S Roy, Kelli Cole, Marlee Bogema, Stephanie F Williams, Ulrich A. Duffner, Aly Mageed
Journal: Blood (2014)
Quality of life in early stage Hodgkin lymphoma (HL) patients from the EORTC-GELA H8 Trial (20931): A post-treatment longitudinal study of 1,015 patients
Authors: N. Mounier, N. Heutte, H. Flechtner, A. M. Mellink, P. Brice, I. Gaillard, C. Traulle, C. Ferme, H. Eghbali, M. Henry-Amar
Journal: Journal of Clinical Oncology (2008)

9535 Background: To study the change in post-treatment Quality of life (QOL) and fatigue in HL pts with favorable (H8-F) or unfavorable (H8-U) prognostic features (C Ferme et al, NEJM 2007;357:1916). Methods: In the H8-F, 3 MOPP-ABV plus involved-field radiotherapy (IFRT) were compared with subtotal nodal radiotherapy (STNI) alone. In the H8-U, 6 MOPP-ABV plus IFRT were compared with 4 MOPP-ABV plus IFRT and 4 MOPP-ABV plus STNI. Assessments were made using the EORTC QLQ-C30 (QOL) and the MFI-20 (Multidimensional Fatigue Inventory questionnaire). Questionnaires were given to pts in complete remission after end of treatment and at regular intervals for 5 years. Mixed models were used to assess reliable changes with time (0–6, 7–14, 15–21, 22–32, 33–47, ≥ 48 month). The impact of gender, age, prognostic group (H8-F vs H8-U), treatment arm and toxicity was also tested. Logistic regression on long term fatigue was performed to identify predictors among MFI-20 scales. Difference between countries were analyzed on Belgian, French and Dutch pts. P<0.01 was considered significant. Results: Of the 1,577 pts enrolled in the trial (median follow-up 92 months), 1,015 participated (4,877 forms). Improvement over time was observed for all scales except reduced motivation. Correlation was observed between: age and all scale changes except emotional functioning; gender (M<F) and physical functioning, emotional functioning, global QOL, fatigue, sexual functioning, and general fatigue; prognostic group (but not treatment arm) and social functioning; toxicity and reduced motivation. A country effect was observed: French pts had worse scores for emotional and social functioning, fatigue, and reduced motivation; in contrast, Dutch pts had worse scores for reduced activity. Belgian pts were intermediate except for reduced activity (higher scores). Finally, long-term fatigue was only influenced by age. Conclusions: QOL data from the re-adaptation of pts to normal life within 5 years after the end of therapy show substantial limitations. The impact of initial treatment is limited to its toxicity. However, fatigue remains of great concern in these pts with different results between countries. No significant financial relationships to disclose.
Foxo3 Transcription Factor Drives Pathogenic T Helper 1 Differentiation by Inducing the Expression of Eomes
Authors: Caroline Stienne, Michaël F. Michieletto, Mehdi Benamar, Nadège Carrié, Isabelle Bernard, Xuan-Hung Nguyen, Yannick Lippi, Fanny Duguet, Roland S. Liblau, Stephen M. Hedrick, Abdelhadi Saoudi, Anne S. Dejean
Journal: Immunity (2016)
Implementation of NIH Criteria for Standardization of Chronic Graft-Versus-Host Disease in Croatia: Two-Year Experience
Authors: Lana Desnica, Drazen Pulanic, Ranka Serventi Seiwerth, Nikolina Matic, Marinka Mravak Stipetic, Ervina Bilic, Romana Ceovic, Dina Ljubas Kelecic, Ljubica Rajic, Ernest Bilic, Nadira Durakovic, Zinaida Peric, Tajana Klepac Pulanic, Tamara Vukic, Igor Petricek, Davorka Dusek, Ines Bojanic, Ema Prenc, Iva Ozana Prah, Magdalena Grce, Renata Zadro, Drago Batinic, Radovan Vrhovac, Steven Z. Pavletic, Damir Nemet
Journal: Blood (2015)
TCT-93 Improvement in Renal Function and its Impact on All-cause Mortality after Transcatheter Aortic Valve Replacement (TAVR): Experience from the PARTNER Trial
Authors: Nirat Beohar, Darshan Doshi, Vinod Thourani, Hanna A. Jensen, Susheel Kodali, Girma M. Ayele, Maria Alu, Michael Mack, Samir Kapadia, Martin Leon, Ajay J. Kirtane
Journal: Journal of the American College of Cardiology (2015)
The Bcl-2 Family Protein Inhibitor, ABT-263, Promotes Apoptotic-Like Response in Isolated Platelets.
Authors: Chris Tse, Haichao Zhang, Jun Chen, Ryan M. Fryer, Richard Nelson, Paul Nimmer, Glenn A. Reinhart, Morey L. Smith, Stephen K. Tahir, Saul H. Rosenberg, Steven W. Elmore
Journal: Blood (2006)
TCT-74 Proximal Balloon Occlusion versus Distal Filter Protection in Carotid Artery Stenting: A Meta-Analysis of Clinical Trial Data
Authors: Jad Omran, Obai Abdullah, Belal Firwana, Mazen Abu-Fadel, Christopher White, William A. Gray, Herbert Aronow, Ashraf Al-Dadah
Journal: Journal of the American College of Cardiology (2015)
TCT-250 Prognostic Impact of Combined Contrast-Induced Acute Kidney Injury (CI-AKI) and Hypoxic Liver Injury (HLI) in Patients with ST Elevation Myocardial Infarction (STEMI) Who Underwent Primary Percutaneous Coronary Intervention (PCI) : Results from the INTERSTELLAR Registry
Authors: Sung Woo Kwon, Sang-Don Park, Tae-Hoon Kim, Ho-Jun Jang, Hyun Woo Park, Jon Suh, Sung-Hee Shin, Sung-Il Woo, Dae-Hyeok Kim, Jun Kwan, Pyung Chun Oh, Jeonggeun Moon, Woong Chol Kang
Journal: Journal of the American College of Cardiology (2015)
Norepinephrine Improves The Generation Of Hematopoietic Cells From Human Pluripotent Stem Cells With Increased Functional Properties
Authors: Carolina Guibentif, Roger Emanuel Rönn, Roksana Moraghebi, Emanuela Monni, Marita Grönning Madsen, Zaal Kokaia, Olle Lindvall, Niels-Bjarne Woods
Journal: Blood (2013)
Combinatorial TGF-β signaling blockade and anti-CTLA-4 antibody immunotherapy in a murine BRAF<sup>V600E</sup>-PTEN-/- transgenic model of melanoma.
Authors: Brent Allen Hanks, Alisha Holtzhausen, Kathy Evans, Michelle Heid, Gerard C. Blobe
Journal: Journal of Clinical Oncology (2014)

3011 Background: T cell-targeted checkpoint inhibitor immunotherapy for melanoma and other solid tumor malignancies only benefits a subpopulation of patients. Our work has shown that melanoma-expressed factors including TGF-β can generate an immune privileged site by suppressing the function of critical dendritic cell populations within the local immune microenvironment. We hypothesized that inhibiting TGF-β signaling in the tumor microenvironment could augment the efficacy of anti-CTLA-4 antibody therapy in a murine transgenic model of melanoma. Methods: Upon primary melanoma development in Tyr::CreER;BrafCA/+;PTENlox/loxmice, the LY2157299 type I TGF-β receptor serine/threonine kinase inhibitor was administered daily by oral gavage accompanied by intra-peritoneal delivery of anti-CTLA-4 monoclonal antibody (mAb) every three days. Tumor development was monitored by caliper and photodocumentation/imaging analysis. After 14 days, tumor tissue, tumor-draining lymph node (TDLN) tissue, and lung tissue was resected for whole tissue Western blot analysis, T cell flow cytometry, immunohistochemistry, and indoleamine 2,3-dioxygenase (IDO) enzymatic activity assays. Results: While LY2157299 and anti-CTLA-4 mAb monotherapy failed to suppress melanoma progression, LY2152799-anti-CTLA-4 mAb combination therapy synergistically suppressed both primary melanoma tumor growth as well as melanoma metastasis in this physiologically-relevant transgenic melanoma model. These observations correlated with significant increases in the CD8+ T cell/CD4+FoxP3+regulatory T (Treg) cell ratio in melanoma tissues. In addition, LY2152799 effectively suppressed TDLN-derived dendritic cell IDO enzyme activity and this was found to correlate with diminished levels of Tregs in both TDLN and primary melanoma tissues. Conclusions: TGF-β signaling inhibition is a promising strategy for augmenting the anti-tumor efficacy of immune checkpoint blockade in melanoma. The pharmacological manipulation of the tumor microenvironment to reverse local immune evasion mechanisms and enhance anti-tumor immune responses represents an important avenue for future studies.
Similar Outcome Using Sibling, Unrelated Donor, and Cord Blood Grafts after Reduced-Intensity Conditioning in Children: A Retrospective Study from the SFGM-TC
Authors: Marion Strullu, Myriam Labopin, Regis Peffaut de Latour, Laurence Clement, Jean-Hugues Dalle, Charlotte Jubert, Gerard Michel, Pierre-Simon Rohrlich, Anne Sirvent, Justyna Kanold, Yves Bertrand, Yves Beguin, Catherine Paillard, Fanny Rialland, Mohamad Mohty, Patrice Chevallier
Journal: Blood (2014)
A Novel Allogeneic Transplant Conditioning Regimen Designed for Tolerance Induction in Patients with Severe Sickle Cell Disease.
Authors: Elizabeth M. Kang, Matthew Hsieh, Jonathan D. Powell, Beth Link, Theresa Donohue, Gregory Kato, Robert Machado, Mark Gladwin, Griffin Rodgers, John F. Tisdale
Journal: Blood (2005)
Comparative Study on the Anticoagulant Effects of Low Molecular Weight Heparins as Measured by Whole Blood Act, Anti-Xa and a Newly Developed Prothrombinase Induced Clotting Time (PiCT) Assay.
Authors: D. Hoppensteadt, M. Tobu, R. Wahi, O. Iqbal, J. M. Walenga, M. Demir, F. Baltasar, J. Fareed
Journal: Blood (2005)
Nanodomain Regulation of Cardiac Cyclic Nucleotide Signaling by Phosphodiesterases
Authors: Kristen Kokkonen, David A. Kass
Journal: The Annual Review of Pharmacology and Toxicology (2016)

Cyclic nucleotide phosphodiesterases (PDEs) form an 11-member superfamily comprising 100 different isoforms that regulate the second messengers cyclic adenosine or guanosine 3',5'-monophosphate (cAMP or cGMP). These PDE isoforms differ with respect to substrate selectivity and their localized control of cAMP and cGMP within nanodomains that target specific cellular pools and synthesis pathways for the cyclic nucleotides. Seven PDE family members are physiologically relevant to regulating cardiac function, disease remodeling of the heart, or both: PDE1 and PDE2, both dual-substrate (cAMP and cGMP) esterases; PDE3, PDE4, and PDE8, which principally hydrolyze cAMP; and PDE5A and PDE9A, which target cGMP. New insights regarding the different roles of PDEs in health and disease and their local signaling control are broadening the potential therapeutic utility for PDE-selective inhibitors. In this review, we discuss these PDEs, focusing on the different mechanisms by which they control cardiac function in health and disease by regulating intracellular nanodomains.
TCT-633 Predictors for Paravalvular Regurgitation After Transcatheter Aortic Valve Replacement With the Self-Expanding CoreValve Prosthesis: Quantitative Measurement of Multidetector Computed Tomographic Analysis
Authors: Sung-Han Yoon, Yohei Ohno, Marco Barbanti, Jung-Min Ahn, Jason Leung Kwai Chan, Mao-Shin Lin, Young-Hak Kim, Dong Hyun Yang, Sebastiano Immè, Claudia Tamburino, Carmelo Sgroi, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Cheol Whan Lee, Seong-Wook Park, Kam-Tim Chan, Michael K. Lee, Paul Hsien-Li Kao, Corrado Tamburino, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2015)
Reply to M.A.N. Şendur et al and J. Michels
Authors: David F. Penson, Andrew J. Armstrong, Raoul Concepcion, Neeraj Agarwal, Carl Olsson, Lawrence Karsh, Curtis Dunshee, Fong Wang, Kenneth Wu, Andrew Krivoshik, De Phung, Celestia S. Higano
Journal: Journal of Clinical Oncology (2016)
STUDIES IN THE BLOOD CYTOLOGY OF THE RABBIT
Authors: Albert E. Casey
Journal: The Journal of Experimental Medicine (1931)

1. Statistical analyses have been made of the weekly variations in the blood counts of groups of normal rabbits to find whether there exists any relationship between the numerical changes occurring in the various cell types. Consecutive blood counts and differential white cell determinations on five groups of normal male rabbits comprising 45 animals in all were made at weekly intervals from October, 1927, to June, 1929, the number of observations on each group varying from eight to thirty-five. 2. The following relationships between the varying group means were found to be consistent and significant:-The number of the red blood cells varied with the amount of hemoglobin per cubic millimeter and with the number of lymphocytes. There was an inverse relationship between the amount of hemoglobin and the number of monocytes. The neutrophiles varied in number with the monocytes; the basophiles with the eosinophiles; and the eosinophiles with the monocytes. Other associations not always similar but of high significance as far as the combined values were concerned, were the relations of the red blood cells with the basophiles and the monocytes. The relations of the neutrophiles with the red blood cells and the hemoglobin were very irregular. 3. Significant association of the white blood cells with variations in the red blood cells and the hemoglobin content were observed. The numerical variations in the group means of the total white cells were associated with similar variations in the group means of the neutrophiles, the lymphocytes, the monocytes, the basophiles, and the eosinophiles almost to the degree of their numerical occurrence in the peripheral blood. 4. With the exception of the total white cells, approximately only half the variations in the group levels of the various cells and of the hemoglobin content can be accounted for on the basis of simultaneous associations with each other. 5. The red blood cells, the lymphocytes, and the basophiles as one group, the eosinophiles and the monocytes as another group, and the hemoglobin content and the neutrophiles as a third group, described a definite shift from a high to a low numerical value during the 2 year observation period. From the standpoint of the magnitude of the shift, the basophiles, the eosinophiles, the monocytes, the lymphocytes, and the red blood cells participated in the order mentioned. The neutrophiles were only slightly affected and the hemoglobin content relatively not at all. 6. No significant relationship was ever found, even in the component groups, between the weekly mean values of the following: the hemoglobin with the basophiles, the eosinophiles, or the lymphocytes; the neutrophiles with the basophiles or the eosinophiles; and the lymphocytes with the eosinophiles or the monocytes.
TCT-517 Long term clinical outcome following Bioresorbable Vascular Scaffold Implantation for the Treatment of Coronary In-stent Restenosis: a Multicenter Italian Experience
Authors: Elisabetta Moscarella, Attilio Varricchio, Francesco Granata, Sebastian Coscarelli, Eugenio Stabile, Azeem Latib, Alfonso Ielasi, Bernardo Cortese, Maurizio Tespili, Paolo Calabrò, Akihito Tanaka, Claudia Capozzolo, Antonio Colombo
Journal: Journal of the American College of Cardiology (2015)
Initial Results from Study Hgb-206: A Phase 1 Study Evaluating Gene Therapy By Transplantation of Autologous CD34+ Stem Cells Transduced Ex Vivo with the Lentiglobin BB305 Lentiviral Vector in Subjects with Severe Sickle Cell Disease
Authors: Julie Kanter, Mark C. Walters, Matthew Hsieh, Alexis A. Thompson, Lakshmanan Krishnamurti, Janet Kwiatkowski, Rammurti T Kamble, Christof von Kalle, Frans A. Kuypers, Marina Cavazzana, Philippe Leboulch, Laura Sandler, Sandeep Soni, John F. Tisdale
Journal: Blood (2015)
TCL1 Expression Pattern and Its Prognostic Impact In Waldenström’s Macroglobulinemia
Authors: Richard Lemal, Laura Montrieul, Olivier Tournilhac, Aurélie Cabrespine, Aurélie Ravinet, Albane Ledoux-Pilon, Pierre Déchelotte, Mary Callanan, Anouk Emadali, Pierre Verrelle, Jacques-Olivier Bay, Romain Guièze
Journal: Blood (2013)
The sketch is blank: No evidence for an explanatory role for cultural group selection
Authors: Max M. Krasnow, Andrew W. Delton
Journal: Behavioral and Brain Sciences (2016)

Abstract As evidence that cultural group selection has occurred, Richerson et al. simply retrodict that humans use language, punish each other, and have religion. This is a meager empirical haul after 30 years. This contrasts sharply with the adaptationist approach to human behavior – evolutionary psychology – which has produced scores of novel, specific, and empirically confirmed predictions.
Genetically altered <i><b>Salmonella typhimurium</b></i> profoundly increases survival in nude mice with metastatic PC-3 prostate tumors
Authors: R. M. Hoffman, M. Zhao, J. Geller, M. Yang, H. Ma, X. Tan, X. Li
Journal: Journal of Clinical Oncology (2006)

14653 Background: We previously published that a genetically-altered Salmonella typhimurium, expressing GFP, could completely destroy subcutaneously-implanted PC-3 tumors in nude mice when injected locally or intravenously (PNAS 102, 755–60, 2005). The bacteria are leu-arg auxotrophs which enable the bacteria to grow in PC-3 tumors but not in normal tissue. Methods: In the current study, we explore the effect of this bacteria, termed S. typhimurium A1, on metastatic PC-3 tumors orthotopically implanted in nude mice. PC-3 is a non-hormone-dependent prostate cancer. In this study, 20 mice were implanted orthotopically with PC-3 tumors expressing GFP. Approximately 2 weeks following implantation, the tumors were externally imageable. Ten of the 20 mice served as controls and followed until death without treatment. Ten mice were given the S. typhimurium A1 weekly intravenously, beginning at 2 weeks when the tumor GFP was first externally visible, and survival time was compared to the untreated mice. Ten additional non-tumor-bearing mice served as controls for the possible toxicity of S. typhimurium A1 and were also injected weekly with the bacteria intravenously. Results: Of the 10 mice with the PC-3 tumors injected weekly with S. typhimurium A1, 7 were alive and well at the time the last untreated mouse died. Currently, 4 treated mice remain alive and well 17 weeks following implantation. 3 of these 4 mice had no external fluorescence for the past 5 weeks despite discontinuing S. typhimurium A1. One mouse shows a progressive decrease in fluorescence, only a tiny spot if left. This mouse continues on S. typhimurium injection weekly. Conclusions: Injection of genetically-altered leu-arg-auxotrophic S. typhimurium into mice with metastatic PC-3 tumors has resulted in more than the tripling of lifespan of 4 of the mice. Three of the mice appear “cured” and have not external fluorescence despite discontinuing S. typhimurium treatment for the past 5 weeks. One mouse continues on weekly injections of S. typhimurium and is well with decreasing fluorescence. Since human prostate cancer eventually becomes non-androgen-dependent similar to PC-3 tumors, genetically-altered bacteria represent a novel potential treatment for this disease. No significant financial relationships to disclose.
Prostate-Specific Membrane Antigen Uptake in Small Cleaved B-Cell Follicular Non-Hodgkin Lymphoma
Authors: Shankar Vamadevan, Ken Le, Chuong Bui, Robert Mansberg
Journal: Clinical Nuclear Medicine (2016)

A 68-year-old man with treated prostate cancer 3 years earlier and small cleaved B-cell follicular lymphoma diagnosed 1 year prior and monitored clinically with no active intervention (“watch and wait” approach) was referred for 68Ga–prostate-specific membrane antigen (PSMA) PET/CT with rising prostate-specific antigen level. PET/CT demonstrated diffuse PSMA uptake in the prostate (SUVmax 3.6) and multiple PSMA-avid nonenlarged lymph nodes. Moderate PSMA uptake (SUVmax 4.7) was also noted in an enlarged right inguinal lymph node (SUVmax 4.7), which on core biopsy confirmed small cleaved B-cell follicular lymphoma.
Functional T Cell Array Reveals Pre-Treatment Expanded Terminal Effector Memory Response Is Associated with Lenalidomide Failure in Non-Del(5q) Myelodysplastic Syndrome.
Authors: P.K. Epling-Burnette, JianXiang Zou, Jeffrey S. Painter, Dung-Tsa Chen, Jimmy Fulp, Rami S. Komrokji, Sheng Wei, Alan F List
Journal: Blood (2009)
TCT-506 Two-Year Outcomes After Bioresorbable Scaffold Implantation– The Multicenter ASSURE Registry
Authors: Carsten Schwencke, Christoph Naber, Jochen Wöhrle, Thomas Schmitz, Norbert Frey, Christian Butter, Johannes Brachmann, Detlef Mathey
Journal: Journal of the American College of Cardiology (2015)
TCT-697 Relationship between the degree of device oversizing and clinical outcomes in patients treated with transcatheter aortic valve replacement using balloon-expandable or self-expanding valves: Insights from the randomized CHOICE trial
Authors: John Jose Erungaren, Mohamed El-Mawardy, Julinda Mehilli, Christian Frerker, Franz-Josef Neumann, Doreen Richardt, Ralph Toelg, Gert Richardt, Mohamed Abdel-Wahab
Journal: Journal of the American College of Cardiology (2015)
Association of daptomycin use with resistance development in Enterococcus faecium bacteraemia—a 7-year individual and population-based analysis
Authors: A. Egli, H. Schmid, E. Kuenzli, A.F. Widmer, M. Battegay, H. Plagge, R. Frei, R. Achermann, M. Weisser
Journal: Clinical Microbiology and Infection (2016)
Effect of the BET Inhibitor, Cpi-0610, Alone and in Combination with Lenalidomide in Multiple Myeloma
Authors: Ka Tat Siu, Homare Eda, Loredana Santo, Janani Ramachandran, Miroslav Koulnis, Jennifer Mertz, Robert J. Sims, Michael Cooper, Noopur S. Raje
Journal: Blood (2015)