tbuckley/cabot-search huggingface dataset:
Congenital Cytomegalovirus Infection
Authors: Gail J. Demmler-Harrison
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
TCT-444 A Novel Modified Provisional Bifurcation Stenting Technique: Jailed Semi-inflated Balloon Technique
Authors: Murat Cayli, Taner Seker, Mustafa Gur, Zafer Elbasan, Durmus Y. Sahin, Mehmet A. Elbey, Habib Çil
Journal: Journal of the American College of Cardiology (2015)
The Rise of Henri-Alexandre Danlos and His Contributions to Dermatologic Therapeutics and Radiation Research
Authors: Parth Patel, Arpan V. Prabhu, Chester V. Oddis
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
JAK2 Mutation and Additional Thrombophilic Markers Predispose to Thrombosis in Myeloproliferative Diseases with Thrombocythemia
Authors: Miroslav Penka, Jiri Schwarz, Michael Doubek, Petr Dulicek, Karel Indrak, Yvona Brychtova, Antonin Hlusí, Jarmila Kissova, Jiri Mayer, Tomas Pavlik
Journal: Blood (2008)
Two Independent Effects of Immunoglobulin-Like Receptor (KIR) Allele Matching between Siblings: Inhibitory KIR (iKIR) Mismatches Are Associated with Graft Versus Host Disease (GVHD) While Activatory KIR Matches (aKIR) and cGVHD Are Associated with Graft Versus Leukemia (GVL).
Authors: Klara Dalva, Funda Gungor, Ender Soydan Akcaglayan, Meral Beksac
Journal: Blood (2006)
Genetic and Epigenetic Silencing of Mesoderm Specific Transcript (MEST) In Acute Myelogenous Leukemia.
Authors: Anna R Poetsch, Rainer Claus, Lars Bullinger, Tania Witte, Michael LÃ¼bbert, Michael Rehli, Konstanze Döhner, Christoph Plass
Journal: Blood (2010)
NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
Authors: Evandro Fei Fang, Henok Kassahun, Deborah L. Croteau, Morten Scheibye-Knudsen, Krisztina Marosi, Huiming Lu, Raghavendra A. Shamanna, Sumana Kalyanasundaram, Ravi Chand Bollineni, Mark A. Wilson, Wendy B. Iser, Bradley N. Wollman, Marya Morevati, Jun Li, Jesse S. Kerr, Qiping Lu, Tyler B. Waltz, Jane Tian, David A. Sinclair, Mark P. Mattson, Hilde Nilsen, Vilhelm A. Bohr
Journal: Cell Metabolism (2016)
Case 31-1962
Authors: Janet W. McArthur, Robert E. Scully
Journal: New England Journal of Medicine (1962)

Presentation of CaseA forty-nine-year-old woman entered the hospital because of a mass in the left breast.Erythema and swelling began in the inner quadrants of the breast four months previously and gradually progressed to involve the entire organ, which became hard, with retraction of the nipple. There was no ulceration of the skin, swelling of the arm or bleeding or discharge from the nipple.The patient had always been obese, and her weight increased from 210 to 230 pounds during the two years before admission. She noticed the loss of hair on the scalp and the growth of coarse . . .
Different Isoforms of the B-Cell Mutator Activation-Induced Cytidine Deaminase (AID) Are Aberrantly Over-Expressed in BCR-ABL1-Positive Acute Lymphoblastic Leukemia (ALL) Patients and Promote Genetic Instability.
Authors: Ilaria Iacobucci, Annalisa Lonetti, Anna Ferrari, Simona Soverini, Emanuela Ottaviani, Daniela Cilloni, Sabina Chiaretti, Nicoletta Testoni, Cristina Papayannidis, Francesca Messa, Federica Salmi, Antonella Vitale, Francesca Paoloni, Francesca Arruga, Panagiota Giannoulia, Marco Vignetti, Fabrizio Pane, Pier Paolo Piccaluga, Alessandra Gnani, Stefania Paolini, Giuseppe Saglio, Michele Baccarani, Robert Foà, Giovanni Martinelli
Journal: Blood (2008)
Survival benefit from first docetaxel treatment for cabazitaxel plus prednisone compared with mitoxantrone plus prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) enrolled in the TROPIC trial.
Authors: A. O. Sartor, S. Oudard, M. Ozguroglu, S. Hansen, J. H. Machiels, L. Shen, J. S. De Bono
Journal: Journal of Clinical Oncology (2011)

4525^ Background: Docetaxel is standard first-line chemotherapy for mCRPC. The Phase III TROPIC trial showed that, for patients who progressed during or after docetaxel-based therapy, cabazitaxel plus prednisone (CbzP) improved overall survival (OS) compared with mitoxantrone plus prednisone (MP) (HR 0.70; p < 0.0001) (Lancet 2010; 376:1147–54). We conducted an exploratory analysis of the TROPIC cohort to assess OS from the time of first docetaxel treatment. Methods: Men were randomized to receive either CbzP (n=378) or MP (n=377) after progression on docetaxel. OS was calculated from the time of the first docetaxel dose to death from any cause. The cut-off date for this updated survival analysis was March 10, 2010. The Kaplan–Meier method was used to analyze OS and corresponding 95% confidence intervals (CI) were calculated using the Cox proportional hazards model. Results: At the time of randomization to TROPIC, the treatment arms were balanced with respect to baseline characteristics and prior anticancer therapies. Most patients (85%) had received one prior docetaxel regimen; 15% had received more than one; 88% received docetaxel as their first chemotherapy. The majority were randomized in TROPIC within 6 months of last docetaxel dose, and 72% of CbzP and 76% of MP patients progressed during or within 3 months of last receiving docetaxel; 29% of patients progressed during their last docetaxel treatment. Median prior docetaxel doses were similar (CbzP 576.6 mg/m2 vs. MP 529.2 mg/m2). At the time of this analysis, 73% of CbzP patients and 81% of MP patients had died. Median OS from the time of the first docetaxel dose in the CbzP group was 29 months (95% CI 27–31) vs. 25 months (95% CI 23–28) in the MP group. Conclusions: This post hoc analysis of the TROPIC trial shows that CbzP extends survival from the time of the first docetaxel treatment compared with MP in men with mCRPC. This exploratory analysis has limitations in generalizability to real-life practice. Not all mCRPC patients with post-docetaxel progression will be eligible for CbzP because of either performance status or organ function.
Geoffrey Arthur Evelyn Baker
Authors: Tim Baker
Journal: BMJ (2016)

Geoffrey Arthur Evelyn Baker (“Geoff”) entered general practice in 1956, joining Bill Branch in Englefield Green and working from Branch’s front room. He remained in the same practice for 35 years, helping to develop it into a thriving training practice based in a modern health centre, with a branch surgery in Old Windsor. He retired from general practice at the age of 62 but continued working as medical adviser to an insurance …
The mechanisms and effects of GSK-3β inhibitor on cellular multidrug resistance in colon carcer cells.
Authors: Kunping Liu, Xuefang Wu, Feng Luo
Journal: Journal of Clinical Oncology (2015)

e13592 Background: GSK-3β participates in a variety of important physiological processes. However, the roles of GSK-3 β in the biological properties and drug resistance of tumor cells remains controversial. In this study, the effects of GSK-3β inhibitor (2'Z,3'E)-6-bromoindirubin-3'-oxime (BIO) on cellular multidrug resistance of Colon cancer cells, and the roles of Wnt/β-catenin pathway and cancer stem cells (CSCs) in this process were investigated. Methods: The colon cancer SW480 and SW620 cells were treated with BIO, 5-fluorouracil (5-FU), BIO/5-FU, Cisplatin (DDP) and BIO/DDP separately. The intracellular ATP concentration was detected by luminometer. Cell apoptosis level was detected by flow cytometry. The expressions of GSK-3β, p-GSK-3β, β-catenin, E-cadherin and CSCs markers EpCAM, TERT, and DCAMKL-1 protein were detected by Western blot. The expressions of CD133 protein were detected by Flow Cytometry. Results: Compared with those colon cancer cells untreated with BIO, The intracellular ATP concentration is slightly elevated in SW480 and SW620 cells After BIO treatment. The apoptosis induced by 5-Fu and DDP were reduced significantly in SW480 cells after BIO treatment (P < 0.05), whereas the effects were slight in SW620 cells (P > 0.05). BIO significantly reduces the expression of p-GSK-3β protein in SW480 and SW620 cells (P < 0.05), but the change of GSK-3β protein were not obvious (P > 0.05). BIO significantly increased the expression of β-catenin and E-cadherin protein in SW480 and SW620 cells (P < 0.05), and promoted nuclear translocation of β-catenin protein. BIO significantly increased the expression of EpCAM, TERT and DCAMKL-1 protein in SW480 cells (P < 0.05), but the change of CD133 expression was not obvious (P > 0.05). BIO significantly up-regulated the expression of EpCAM protein in SW620 cells (P < 0.05), but the change of CD133, TERT and DCAMKL-1 protein expression were not significant (P > 0.05). Conclusions: The GSK-3β inhibitor BIO could affect cellular multidrug resistance of colon cancer cells in vitro, and the Wnt/β-catenin pathway and CSCs may play some roles in this process. GSK-3β may be a regulating target of drug resistance in colon cancer.
TCT-43 Mechanical abnormalities associated to drug eluting stent thrombosis analyzed by optical coherence tomography in the national PESTO French registry
Authors: Nicolas Amabile, Claire-Marie Tissot, Charlotte Trouillet, Xavier Chabin, Pierre Barnay, Regis Delaunay, Sebastien Levesque, Thibault Lhermusier, Gilles Rioufol, Geraud Souteyrand
Journal: Journal of the American College of Cardiology (2015)
TCT-417 Treatment of coronary artery disease with a new-generation drug-coated balloon: preliminary results from the Italian Elutax SV Registry
Authors: Bernardo Cortese, Raffaela Fetiveau, Alessandro Carrera, Simonetta Blengino, Vruyr Balian, Renata Rogacka, Corrado Lettieri, Andrea Pavei, Carlo Pierli, Marco Crenna, Simone Tresoldi, Francesca Buffoli, Arnaldo Poli
Journal: Journal of the American College of Cardiology (2015)
French Aedes albopictus are able to transmit yellow fever virus
Authors: Fadila Amraoui, Marie Vazeille, Anna Bella Failloux
Journal: Eurosurveillance (2016)

We assessed the ability of a French population of Aedes albopictus to transmit yellow fever virus (YFV). Batches of 30 to 40 female mosquitoes were analysed at 7, 14 and 21 days post-exposure (dpe). Bodies, heads and saliva were screened for YFV. Infectious viral particles were detected in bodies and heads at 7, 14 and 21 dpe whereas the virus was found in saliva only from 14 dpe. Our results showed that Ae. albopictus can potentially transmit YFV.
99mTc-Labeled Ubiquicidin Accumulation in a Retained Surgical Gauze
Authors: Somayeh Ghahremani, Ramin Sadeghi, Vahid Reza Dabbagh Kakhki, Toktam Massoudi, Kamran Aryana
Journal: Clinical Nuclear Medicine (2016)

A 31-year-old woman underwent 99mTc-labeled UBI scanning for diagnosis of possible prosthesis infection evaluation in our department. The scan showed an area of increased tracer uptake in the mid-lateral portion of the left thigh. This was proven to be due to a retained surgical gauze in her left thigh.
GW27-e0262 A study on the mechanism of the Caveolin-1 in Ginsenoside Rb1 against the replicative senescence of endothelial cells
Authors: Bin Zhou, Dinghui Liu, Shujie Yu, Lin Wu, Yong Liu, Baoshun Hao, Lin Chen, Xiaoxian Qian
Journal: Journal of the American College of Cardiology (2016)
Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis
Authors: Yinyin Li, Yi Shen, Philipp Hohensinner, Jihang Ju, Zhenke Wen, Stuart B. Goodman, Hui Zhang, Jörg J. Goronzy, Cornelia M. Weyand
Journal: Immunity (2016)
Intracavitary IL-2 immunotherapy in malignant pleural effusion. Phase II study
Authors: V. D. Ferrari, G. F. Tassi, P. Marchetti, M. Trignani, F. Valcamonico, G. Marini
Journal: Journal of Clinical Oncology (2004)

7114 Background: Malignant pleural effusion (MPE)is often refractory to cytotoxic agents and is frequently complicated by severe impairment of quality of life and easily relapse after conservative treatments. Pts with MPE from solid tumors requiring sclerosis were treated with insufflation by thoracoscopy(TI) via chest tube(CT). Methods:In order to assess the palliative and therapeutic activity of IL-2 in unresectable MPE, we performed a phase II study on 100 consecutive patients (M/F 73/23); median age was 58,8 years ( range 31–79), median ECOG PS was 0,5 (range 0–2); primary cancers were mesothelioma (66 % : epithelial 58, biphasic 4, sarcomatous 4 ) lung (20 %), breast (7 %), kidney (5%), gastric and ovarian 1%, all pts were Caucasian . Mesothelioma tumors were 12 in stage IA, 7 in stage IB, 36 in stage II; 4in stage IV), the other cancers were in stage IV. Pts received as first-line treatment intrapleural instillation of IL-2 21.000.000 IU/m2 in 120 ml of saline solution over 24 hours for 5 days, after thoracoscopy. After 3–4 weeks chemo-immunotherapy was administered to 61 % of patients according to schedule of systemic therapy. Results: Toxicity (WHO criteria) with intrapleural IL-2 consisted of grade 2 fever in 36 % of patients and of grade 2 cardiac late toxicity (pericardial effusion ) in one patient (3%) two months after the end of treatment; 6 pts developed skin reaction grade 1; 2 pts had pleural infection and 2 pts lung dysfunction with dispnea grade 2. We did not observe toxicity grade 3–4 or toxic death. In 92 % of patients there was no further or minimal (asymptomatic) pleural fluid collection (according to Paladine criteria); pleurisy was unusefull only in 8 patients. . The overall survival was 20,5% at 24 months and 12,8 at 36 months. Median overall survival was 15 months (range 5–39) in all patients. Conclusions: IL-2 intrapleural administration in pleurisy-complicated MPE is feasible and active both in palliation of pleural effusion and on primary or metastatic tumor; with manageable toxicity. The overall survival observed warrants further randomized studies with IL-2 No significant financial relationships to disclose.
GW27-e0058 Comparisons of loading doses of ticagrelor versus clopidogrel in preventing periprocedural myocardial infarction
Authors: Ling-Xia Xu, Kang-Yin Chen, Tong Liu, Xin-Tian Zheng, Jing-Jin Che, Guangping Li
Journal: Journal of the American College of Cardiology (2016)
TCT-698 Incremental Value of Computed Fractional Flow Reserve in Patients Referred to Transcatheter Aortic Valve Replacement
Authors: Anas Fares, Marwan Nasif, Mohamad Amer Alaiti, Setsu Nishino, Daisuke Nakamura, Guilherme F. Attizzani, Marco Costa, Daniel Simon, Hiram Bezerra
Journal: Journal of the American College of Cardiology (2015)
Use of HE4 expression in plasma to predict operative outcome in patients with ovarian cancer (OC).
Authors: E. I. Braicu, R. Zeillinger, I. B. Vergote, S. Mahner, A. G. Zeimet, I. Cadron, D. Castillo-Tong, R. Chekerov, B. Brandt, J. Sehouli
Journal: Journal of Clinical Oncology (2010)

5022 Background: OC is the major cause of death due to gynecological malignancies. Its treatment consists in cytoreductive surgery followed by platinum based chemotherapy. The most important prognostic factor for overall and disease free survival is the residual tumor mass after surgery. Aim of our study is to analyze the role of HE4 in predicting surgical outcome. Methods: Between February 2005 and December 2008 302 consecutive patients with epithelial OC were enrolled. Samples were obtained from the European, multicentric prospective project OVCAD. OC patients were eligible if radical cytoreductive surgery was performed and standard chemotherapy with paclitaxel and carboplatin was applied. A prospective intra- and postoperative documentation was used. Plasma and ascites samples were collected before or during surgery. HE4 concentrations were determined using the ELISA technique. Results: Median age at the time of diagnosis was 58 years (range 18-85 years). Most patients presented with advanced stage disease, FIGO III or IV (94 %), grade 2 or 3 (95.1%), serous histology (86.6%) and lymph node involvement (49.7%). Peritoneal carcinomatosis (54.5%) and ascites (56.8%) were common. In most cases a complete cytoreduction was obtained (69.9%). The HE4 expression in ascites didn’t correlate with any clinical prognostic factors, such as FIGO stage, histological type, grading, amount of ascites and residual mass. The HE4 expression in plasma was significantly associated with FIGO stage (p < 0.001) and amount of ascites (p = 0.002). HE4 expression in plasma correlated with the outcome of cytoreductive surgery (p = 0.001). Patients having HE4 circulatory levels between 70-200 pg/mL, have a higher chance to benefit from surgery (OR: 0.810, 95%CI: 0.274-2.395) in comparison with patients having HE4 levels higher than 200 pg/mL (OR: 0.347, 95%CI: 0.136-0.885). In the multivariate analysis only FIGO stage is significantly associated with the surgical outcome. Conclusions: The presented data are showing that HE4 expression in blood can be used for identifying the collective of OC patients who will benefit from the cytoreductive surgery. No significant financial relationships to disclose.
Updating the diagnosis, classification and assessment of rosacea: recommendations from the global <scp>ROS</scp> acea <scp>CO</scp> nsensus ( <scp>ROSCO</scp> ) panel
Authors: J. Tan, L.M.C. Almeida, A. Bewley, B. Cribier, N.C. Dlova, R. Gallo, G. Kautz, M. Mannis, H.H. Oon, M. Rajagopalan, M. Steinhoff, D. Thiboutot, P. Troielli, G. Webster, Y. Wu, E.J. Zuuren, M. Schaller
Journal: British Journal of Dermatology (2016)

Rosacea is currently diagnosed by consensus‐defined primary and secondary features and managed by subtype. However, individual features (phenotypes) can span multiple subtypes, which has implications for clinical practice and research. Adopting a phenotype‐led approach may facilitate patient‐centred management. To advance clinical practice by obtaining international consensus to establish a phenotype‐led rosacea diagnosis and classification scheme with global representation. Seventeen dermatologists and three ophthalmologists used a modified Delphi approach to reach consensus on statements pertaining to critical aspects of rosacea diagnosis, classification and severity evaluation. All voting was electronic and blinded. Consensus was achieved for transitioning to a phenotype‐based approach to rosacea diagnosis and classification. The following two features were independently considered diagnostic for rosacea: (i) persistent, centrofacial erythema associated with periodic intensification; and (ii) phymatous changes. Flushing, telangiectasia, inflammatory lesions and ocular manifestations were not considered to be individually diagnostic. The panel reached agreement on dimensions for phenotype severity measures and established the importance of assessing the patient burden of rosacea. The panel recommended an approach for diagnosis and classification of rosacea based on disease phenotype.
Identification of Proteinase 3 (PR3) Gene Overexpresison and Protein Delocalization in Core Binding Factor Leukemias as a Mechanism Leading to Increased Chemosensitivity.
Authors: Daniela Cilloni, Ilaria Defilippi, Sonia Carturan, Chiara Maffè, Marisa Pautasso, Ilaria Iacobucci, Giovanni Martinelli, Emanuela Messa, Antonia Rotolo, Enrico Bracco, Giuseppe Saglio
Journal: Blood (2008)
Are Patients Who Have Recovered From ADAMTS13-Deficient Thrombotic Thrombocytopenia Purpura (TTP) at Risk for Developing Systemic Lupus Erythematosus (SLE)?
Authors: Deirdra R. Terrell, Zayd Al-Nouri, Judith A. James, Johanna A. Kremer Hovinga Strebel, Bernhard Lämmle, Sara K. Vesely, James N. George
Journal: Blood (2010)
Successful Treatment of Intra-Cranial Hemorrhage with Repeated Doses of Activated Recombinant FVII in a Newborn with Severe Factor VII Deficiency.
Authors: Roula Farah, Dany Hamod, Elie Bechara, Nancy Melick, Paul Hage, Muriel Giansily-Blaizot, Ahmed S. Sallah
Journal: Blood (2006)
TCT-552 SERIAL ASSESSMENT OF CALCIFICATION 5 YEARS AFTER BIORESORBABLE VASCULAR SCAFFOLD IMPLANTATION: FUSION OF INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY
Authors: Yaping Zeng, Hiroki Tateishi, Rafael Cavalcante, ERHAN TENEKECIOGLU, Pannipa Suwannasom, Yohei Sotomi, Carlos Collet, Shao-Ping Nie, Hans Jonker, Jouke Dijkstra, Maria Radu, Lorenz Raber, Dougal Mcclean, Robert-Jan van Geuns, Evald Christiansen, Fahrni Therese, Jacques Koolen, Yoshinobu Onuma, Patrick Serruys
Journal: Journal of the American College of Cardiology (2016)
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers
Authors: Genaro R. Villa, Jonathan J. Hulce, Ciro Zanca, Junfeng Bi, Shiro Ikegami, Gabrielle L. Cahill, Yuchao Gu, Kenneth M. Lum, Kenta Masui, Huijun Yang, Xin Rong, Cynthia Hong, Kristen M. Turner, Feng Liu, Gary C. Hon, David Jenkins, Michael Martini, Aaron M. Armando, Oswald Quehenberger, Timothy F. Cloughesy, Frank B. Furnari, Webster K. Cavenee, Peter Tontonoz, Timothy C. Gahman, Andrew K. Shiau, Benjamin F. Cravatt, Paul S. Mischel
Journal: Cancer Cell (2016)