tbuckley/cabot-search huggingface dataset:
Prevention of Myocardial Necrosis by Advanced Pregnancy
Authors: David Lehr
Journal: JAMA (1961)

IN THE COURSE of studies on the influence of acute hyperparathyroidism on gestation and fetal development in the albino rat, it was found that advanced pregnancy exerts a remarkable protective action against the toxic sequelae of parathyroid hormone overdosage. This observation led to a systematic investigation of the protection afforded by pregnancy against the deleterious effects of the acute hyperparathyroid state which entail severe myocardial necrosis and nephrocalcinosis. The results of these studies form the subject of the present report. <h3>Methods and Materials</h3> Albino rats in the first, second, and third week of gestation and nonpregnant female littermates were injected with parathyroid hormone (PTH) subcutaneously, in a dosage of 150 USP units twice daily on 3 successive days. Tail blood was obtained before the first PTH injection and 48 hours later for determination of total calcium<sup>1</sup>and inorganic phosphate<sup>2</sup>in the serum. Animals surviving the acute hyperparathyroid state
Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling
Authors: Alesha Grant, Sanket S. Ponia, Shashank Tripathi, Vinod Balasubramaniam, Lisa Miorin, Marion Sourisseau, Megan C. Schwarz, Mari Paz Sánchez-Seco, Matthew J. Evans, Sonja M. Best, Adolfo García-Sastre
Journal: Cell Host & Microbe (2016)
'Do not resuscitate' orders
Authors: R I Misbin
Journal: JAMA (1986)

<h3>In Reply.—</h3> We agree with Drs Elliott and Day and Dr La Puma that DNR orders mean that only cardiopulmonary resuscitation should be withheld. The hospitals in our study all based their practices on this definition. Like many forms of treatment, cardiopulmonary resuscitation might be accepted or rejected by a patient or surrogate, depending on its appropriateness.<sup>1</sup>It would be improper to use DNR orders to sanction death, withdraw therapy, or fail to relieve pain or provide comfort, and nothing in our study indicated that this occurred. Nevertheless, while guidelines and policies for writing DNR orders are widely available, physicians have received little guidance about how to indicate and proceed with other treatment limitations.<sup>2,3</sup>Acronyms indicating such limits (DNI [do not intubate], SCO [supportive care only], or DNT [do not treat]) are not widely recognized, well characterized, or used. As indicated in our article, however, DNR decisions "were
Smoking and Abortion
Authors: H E McKean
Journal: New England Journal of Medicine (1978)

This is a letter criticizing the conclusions of a previously published study regarding the association between maternal smoking and spontaneous abortion. The tabular presentation of the data are said to skew the results. It is pointed out that the data show the risk of spontaneous abortion to be significantly greater only for young smokers. Interpretation of any possible association between smoking and spontaneous abortion should consider the reason for the smoking, e.g., if the woman were smoking out of worry for a troubled pregnancy. The study by Kline et al. did not control for marihuana use or drinking, both of which behaviors might also have had a relationship to the spontaneous abortion. The trauma of abrupt withdrawal might be a greater risk for a smoking pregnant woman than gradual reduction to lower levels consistent with a trouble-free pregnancy.
P0214 : Predictors of response and outcome to terlipressin in patients with hepatorenal syndrome
Authors: S. Vinit, A. Kumar, P. Sharma, R.K. Bansal, P. Tyagi, N. Bansal, V. Singla, M. Kumar, P. Ranjan, M.K. Sachdeva, A. Arora
Journal: Journal of Hepatology (2015)
Wound Irrigation in Initial Management of Open Fractures
Authors: Olivier Barbier, Pierre Pasquier
Journal: New England Journal of Medicine (2016)

To the Editor: In reporting on the results of the Fluid Lavage of Open Wounds (FLOW) trial, Bhandari et al. (Dec. 31 issue)1 describe the initial management of open fracture wounds. According to their protocol, the investigators aimed to perform irrigation and debridement for skin and soft-tissue defects or to close wounds that had delayed union or nonunion with the use of grafting or muscle flaps within 7 to 14 days after the initial surgery. The use of low-pressure wound therapy (vacuum-assisted closure) was described. We wonder whether the investigators adhered to the protocol regarding definitive wound coverage, and we wonder about the number and duration of vacuum-assisted closure procedures used in the trial, since the application of these techniques is controversial. Delayed wound healing may result in exogenous superinfection, which is often polymicrobial.2 In our experience, superinfection is not prevented but may be facilitated by prolonged vacuum-assisted closure therapy.3 Skin flora microorganisms can migrate into the wound and adhere to internal fixation material, leading to nonunion or a high rate of recurrent infection.4 One of the primary end points of the trial was reoperation at the operative site within 12 months after the initial procedure in order to treat an infection. Information on the number and duration of vacuum-assisted closure procedures used in the trial might provide valuable insight into the association of the use of this procedure with later infection.
ABC of wound healing: Burns
Authors: Alex Benson, William A Dickson, Dean E Boyce
Journal: BMJ (2006)

About 250 000 people are burnt each year in the United Kingdom. Of these, almost 112 000 attend an emergency department, and about 210 die of their injuries. At least 250 000 others attend their general practitioner for treatment of their injury. A burn results in loss of epidermal integrity of the skin; this article discusses the cause and management of various types of burn injury
The influence of major depression on clinical and psychometric assessment of senile dementia of the Alzheimer type
Authors: E H Rubin, D A Kinscherf, E A Grant, M Storandt
Journal: American Journal of Psychiatry (1991)

The performance on standard clinical and psychometric assessments of eight elderly individuals with major unipolar depression alone and seven with depression plus mild senile dementia of the Alzheimer type was compared with that of 41 nondepressed subjects suffering from very mild senile dementia of the Alzheimer type, 66 with mild senile dementia of the Alzheimer type, and 83 age-matched subjects without senile dementia.Subjects with depression alone, depression plus mild senile dementia of the Alzheimer type, and very mild and mild senile dementia of the Alzheimer type met strict inclusionary and exclusionary criteria. A 90-minute semistructured interview, including several brief standardized clinical scales, was used to assign a Clinical Dementia Rating to each subject according to published guidelines, and each subject was given a 2-hour psychometric test battery. Data were analyzed by one-way multivariate analysis of variance to ascertain if there was an effect of group on clinical and psychometric test scores.The eight depressed subjects without concurrent dementia performed as well as the 83 nondepressed subjects without dementia on most clinical measures; however, their performance on most psychometric measures closely resembled that of the 41 nondepressed subjects with very mild dementia. The performance of the seven subjects with depression plus mild dementia was comparable to that of the 66 nondepressed subjects with mild dementia on most clinical and psychometric measures.Although depressed subjects performed as well as subjects without dementia on many clinical assessments, psychometric testing was not able to distinguish depressed subjects from those with very mild senile dementia of the Alzheimer type. This demonstrates the need for careful psychiatric evaluation before interpreting deficits on psychometric tests as indicating the presence of very mild senile dementia of the Alzheimer type.
Second malignancies from adjuvant chemotherapy? Too soon to tell.
Authors: I C Henderson, R Gelman
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.8.1135 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3625242 Second malignancies from adjuvant chemotherapy? Too soon to tell. I C HendersonxI C HendersonSearch for articles by this author , R GelmanxR GelmanSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.8.1135 First Page PDF © 1987 by American Society of Clinical Oncology
Image Gallery: Brain? no, melanoma
Authors: S. Piana, E. Moscarella, C. Longo
Journal: British Journal of Dermatology (2016)

Dear Editor, Desmoplastic melanoma is an aggressive, deeply invasive variant of melanoma. Although the diagnosis is usually suspected in routine sections, immunohistochemical stains are mandatory to rule out other spindle cell malignancies. In this case of desmoplastic melanoma on the face of a 74-year-old man, the immunohistochemical stain with S100 highlights the extraordinarily well-formed dendritic morphology of the neoplastic melanocytes, closely resembling nervous tissue (upper panel). Melanocytic dendrites are long, interlacing and gently wrapped around myocytes of the deep skeletal muscle layer (lower panel). Despite the well differentiated histological features, the neoplasm is locally very aggressive. The magnification of all the figures is × 200.
Benign Multiple Sclerosis
Authors: Gilad Winder, Anat Achiron
Journal: BMJ (1964)

Multiple sclerosis is a demyelinating disease of the central nervous system affecting young adults and leading to significant disability over time. The disease subtype, which results in minimal disability over time, has been defined as benign multiple sclerosis. This review will discuss the various features of benign multiple sclerosis, including cognitive and motor criteria for defining the disability, the disease duration, magnetic resonance imaging characteristics, disease progression and criteria for treatment.
Lack of Intrinsic Incompatibility Between Tissues of Different Genetic Origin
Authors: Richmond T. Prehn
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Lack of Intrinsic Incompatibility Between Tissues of Different Genetic Origin Get access Richmond T. Prehn Richmond T. Prehn National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 4, February 1953, Pages 873–881, https://doi.org/10.1093/jnci/13.4.873 Published: 01 February 1953 Article history Received: 23 September 1952 Published: 01 February 1953
Response to hyperventilation and 5.5% CO2 inhalation of subjects with types of specific phobia, panic disorder, or no mental disorder
Authors: M M Antony, T A Brown, D H Barlow
Journal: American Journal of Psychiatry (1997)

This study tested the hypothesis that compared to other DSM-IV specific phobia types, situational specific phobias have more in common with panic disorder and agoraphobia.Responses to hyperventilation and CO2 inhalation were compared across groups of patients with the four main DSM-IV specific phobia types, a group with panic disorder, and a group of comparison subjects with no anxiety disorder (N = 15 per group).Although these challenges have been shown previously to distinguish patients with panic disorder from other groups, no groups differed significantly in their responses to hyperventilation. In addition, whereas the patients with panic disorder responded more to the CO2 challenge than did the normal subjects, the specific phobia groups did not differ from one another or from the other groups on most measures. For the few CO2 measures on which specific phobia groups differed, patients with situational and natural environment phobias showed the greatest response.Overall, these findings provided only limited support for the hypothesis that situational specific phobias are related to panic disorder.
Rethinking Radical Cystectomy as the Best Choice for Most Patients With Muscle-Invasive Bladder Cancer
Authors: Timur Mitin
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abstract P1-12-09: The oncologic effect of a gonadotropin releasing hormone (GnRH) agonist for ovarian protection during breast cancer chemotherapy
Authors: HJ Kim, MH Lee, JE Lee, SH Park, ES Lee, Y-J Kang, JH Lee, HN Shin, SI Kim, SA Im, SH Ahn, KS Lee, J Sohn, W Han, SJ Nam
Journal: Cancer Research (2016)

Abstract Background: Recently, chemotherapy with a GnRH agonist was reported to protect against ovarian failure. This study was aimed at determining the oncologic effect of a GnRH agonist concurrent with chemotherapy for breast cancer patients. Patients and Methods: A total of 1189 patients aged 20 to 40 years with stage I to III breast cancer who received (neo or adjuvant) chemotherapy from five hospitals in Korea from 2002 to 2012 were reviewed. A gonadotropin releasing hormone (GnRH) agonist was given to 410 patients for ovarian protection during chemotherapy (GnRH agonist group), and 779 patients received chemotherapy without ovarian protection (Chemotherapy alone group). A matching strategy was used to create matched sets of two groups by age, stage, hormone receptor status, Her2/neu status, neo or adjuvant chemotherapy, and institute. Results: Survival analysis using Cox regression showed that the GnRH agonist group had better distant metastatic-free survival (HR=0.65, 95%CI 0.44-0.97) outcomes but similar disease free survival (HR=0.78, 95% CI 0.57-1.08) compared with the chemotherapy alone group. The survival benefit was significant for hormone receptor positive, Her2/neu negative breast cancer on distant metastasis (HR=0.44, 95% CI 0.20-0.99) and disease free survival (HR0.47 95% CI 0.23-0.93). Conclusion: Ovarian protection using a GnRH agonist can be safely considered for premenopausal breast cancer patients for whom chemotherapy is planned. Citation Format: Kim HJ, Lee MH, Lee JE, Park SH, Lee ES, Kang Y-J, Lee JH, Shin HN, Kim SI, Im SA, Ahn SH, Lee KS, Sohn J, Han W, Nam SJ. The oncologic effect of a gonadotropin releasing hormone (GnRH) agonist for ovarian protection during breast cancer chemotherapy. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-12-09.
Effect of Cost Sharing on Screening Mammography
Authors: Harvey E Golden
Journal: New England Journal of Medicine (2008)

n engl j med 358;22 www.nejm.org may 29, 2008 2411 Scaffidi P, Misteli T. Lamin A-dependent nuclear defects in human aging. Science 2006;312:1059-63. Cao K, Capell B, Erdos MR, Djabali K, Collins FSA. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci U S A 2007;104:4949-54. McClintock D, Ratner D, Lokuge M, et al. The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin. PLoS ONE 2007;2(12):e1269. 1.
Massage and the Original Swedish Movements.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An adaptive association test for microbiome data
Authors: Chong Wu, Jun Chen, Junghi Kim, Wei Pan
Journal: Genome Medicine (2016)

There is increasing interest in investigating how the compositions of microbial communities are associated with human health and disease. Although existing methods have identified many associations, a proper choice of a phylogenetic distance is critical for the power of these methods. To assess an overall association between the composition of a microbial community and an outcome of interest, we present a novel multivariate testing method called aMiSPU, that is joint and highly adaptive over all observed taxa and thus high powered across various scenarios, alleviating the issue with the choice of a phylogenetic distance. Our simulations and real-data analyses demonstrated that the aMiSPU test was often more powerful than several competing methods while correctly controlling type I error rates. The R package MiSPU is available at https://github.com/ChongWu-Biostat/MiSPU and CRAN.
Liver mispuncture during percutaneous endoscopic gastrostomy in a patient with a partial gastrectomy
Authors: Ezekiel Toh Yoon, Kazuki Nishihara
Journal: Endoscopy (2016)

A 74-year-old man who had undergone partial gastrectomy (Billroth I) for a gastric tumor 15 years previously was admitted to our hospital for post-stroke rehabilitation. Being dysphagic, he was transferred to our hospital with a nasogastric tube; however, long-term tube feeding was deemed necessary and, after careful evaluation, a percutaneous endoscopic gastrostomy (PEG) was performed in an interventional radiology suite with the use of fluoroscopy. A bumper tube-type catheter was inserted using the push technique (Boston Scientific Safety PEG Kit; Natick, Massachusetts, USA) by puncturing the anterior wall of the remaining stomach just before the anastomotic site ([Fig. 1]).
Fatal case of extensively drug-resistant Mycobacterium tuberculosis Beijing genotype infection in an injecting drug user, Athens, Greece, 2012
Authors: K Leuow, D Papaventsis, S Kourkoundi, P Ioannidis, S Karabela, S Tsikrika, I Marinou, A Papavasileiou, M Stone, F Drobniewski, V Paparisos, E Vogiatzakis
Journal: Eurosurveillance (2013)

We present the first fatal case of extensively drug-resistant tuberculosis (XDR-TB) in an injecting drug user (IDU) in Athens, Greece, co-infected with human immunodeficiency virus and hepatitis C virus and discuss the implications for public health. Despite immediate initiation of treatment, the patient's condition gradually deteriorated and he died 16 days after hospital admission because of multiple organ failure. The contact tracing investigation revealed no further infections among the patient's contacts.
Inhibition of Androgen-Induced Comb Growth in the Chick with Methylcholanthrene
Authors: Roy Hertz, William Tullner
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Inhibition of Androgen-Induced Comb Growth in the Chick with Methylcholanthrene Get access Roy Hertz, Roy Hertz National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar William Tullner William Tullner National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 3, December 1947, Pages 121–122, https://doi.org/10.1093/jnci/8.3.121 Published: 01 December 1947 Article history Received: 21 November 1947 Published: 01 December 1947
A phase II trial of extended interval port-a-cath (PAC) flushes.
Authors: Ju-Hsien Chao, Cesar Rodriguez, Mounika Mandadi, Goetz H. Kloecker
Journal: Journal of Clinical Oncology (2014)

e17606 Background: Subcutaneous PACs are an important part of systemic therapy. Complications of PAC maintenance occur in 5-15% cases. A safe, cost effective, and convenient catheter maintenance protocol has not been defined, although manufactures recommend flushing every month. There are very few publications and no prospective studies addressing the feasibility of delayed PAC flushing. This prospective trial intends to define the feasibility of every 3 month port flushes. Methods: Oncology patients with functional PACs were enrolled after completing curative intent therapy. PACs were flushed in 3 month intervals for planned 12 months duration. The study end points are time to port complications and port failures requiring removal. Accrual of 80 patients assured a power of 80% and a significance level of 5% to determine a failure rate of less than 15%. Results: 83 patients enrolled in the study from May 2009 through December 2013. PACs were placed by interventional radiology 60% of cases and 65% of time in the internal jugular vein. Within the study cohort, 7 patients (8.4%, 2.7-14.4% CI) experienced complications. 2 ports required removal. 5 port dysfunctions corrected with tPA. Port dysfunctions occurred in 4, 1, and 2 patients during the second, third, and fourth flush, respectively. No life threatening complications occurred. Conclusions: Our study demonstrates the safety of extended interval port flushes every 3 month. A decreased rate of flushes is safe, decreases costs and optimizes patient satisfaction.