tbuckley/cabot-search huggingface dataset:
PTH-300 The “two-week wait” referral pathway is not associated with improved overall survivals for patients with colorectal cancer
Authors: MI Aslam, B Singh, S Chaudhri, JS Jameson
Journal: Gut (2015)

<h3>Introduction</h3> Two-Week Wait (2WW) referral pathways including referral to treatment targets in NHS were introduced to shorten delays in the diagnosis and treatment of colorectal cancer (CRC), and to improve overall survivals. This study aimed to analyse overall survivals for patients diagnosed with CRC and compare these for mode of referral and referral to treatment times. <h3>Method</h3> A prospectively maintained database of colorectal cancer outcomes (2004–2013) at University Hospitals of Leicester NHS Trust was analysed. Data for patients diagnosed with CRC was analysed for survival comparisons. Comparisons were made for mode of referral (2WW, Urgent, Routine, Emergency, National Bowel Cancer Screening and other screening pathway) and referral to initial treatment times (&lt;62 days group vs. &gt;62 days group). Inter-group and intra-group comparisons were made with Mann-Whitney-U-test. Kaplan-Meier survival probability estimates were calculated for overall survival and log-rank test was used to compare the survival distributions in different groups. <h3>Results</h3> Overall survivals (median time) were significantly (p &lt; 0.001) lower for patients referred on ‘2ww’ pathway (3.5 years, 95% CI: 2.7–4.30), in comparison to ‘Routine’ (5.4 years, 95% CI: 4.5–6.6) pathway. Patients referred on 2ww pathway were 1.34 times more likely to have stage IV disease on presentation in comparison to patients referred on routine pathway. For referral to initial treatment times, there was no significant difference in survivals between &lt;62 days group and &gt;62 days group (7.1 vs. 6.54, p = 0.620). <h3>Conclusion</h3> CRCs detected on 2ww pathway were associated with lower survivals even though these patients were started on their treatment earlier compared to patients referred on regular pathway. <h3>Disclosure of interest</h3> None Declared.
Antipsychotic effects of lithium in schizophrenia
Authors: P E Alexander, D P van Kammen, W E Bunney
Journal: American Journal of Psychiatry (1979)

The lithium carbonate therapy of 13 psychotic schizophrenic patients was evaluated in a placebo-controlled three-week study that was double-blind. Seven of the 13 patients were less psychotic while receiving lithium; 4 of these 7 patients relapsed after lithium withdrawal. Patients who improved during the third week on lithium could be differentiated from nonresponders on the basis of their improvement during the first week. Clinical factors such as diagnosis, prognosis, and symptoms failed to predict responders from nonresponders. To the authors' knowledge, this is the first controlled study to yield positive results with schizophrenic patients treated with lithium alone.
PTH-343 Tube ileostomy – could it replace defunctioning loop ileostomy in elective colorectal anastomotic protection? – a systematic review and meta-analysis
Authors: S Nachiappan, U Datta, A Askari, O Faiz
Journal: Gut (2015)

<h3>Introduction</h3> Loop ileostomy for faecal diversion in elective distal colorectal anastomosis, and its subsequent reversal, are associated with significant patient morbidity and rarely even mortality. Tube ileostomy, may be an alternative technique in distal anastomosis protection, however its evidence base is not established as yet. This systematic review aims to examine differences in outcome between tube ileostomy and defunctioning ileostomy. <h3>Method</h3> A systematic literature search of MEDLINE, EMBASE, Web of Science, and Cochrane database was conducted. Studies reporting on elective left sided/colorectal anastomoses were included. Studies which reported on emergent surgery, small bowel anastomoses or tube ileostomy as a bridging procedure were excluded. The preoperative aspects, such as bowel preparation, intraoperative technique including tube size and configuration, postoperative management such as tube removal timing, nutrition delivery and complications, were assessed. Outcome measures included anastomotic leak, reoperation and stoma or tube ileostomy-related complications. <h3>Results</h3> Seven studies met the inclusion criteria. Three were case series consisting of 101 patients and four were non-randomised comparative studies consisting of 532 patients. Pooled analyses of three comparative studies, comparing tube ileostomy (n = 278) to loop ileostomy (n = 254), revealed no significant differences in anastomotic leak rates [Odds Ratio (OR) 0.85, 95% Confidence Interval (CI) 0.41 – 1.75; I<sup>2</sup>= 0%, p = 0.43]. <h3>Conclusion</h3> There is a re-emergence of interest in the tube ileostomy in the elective setting, in recent years. Pooled analyses of studies comparing tube ileostomy to loop ileostomy, do not show statistically significant differences in anastomotic leak rates. Further refinement of this technique and randomised controlled studies are necessary for this technique to be routinely used by surgeons. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Cataldo PA. Intestinal stomas: 200 years of digging. <i>Dis Colon Rectum</i>. 1999;42(2):137–42 Bugiantella W, Rondelli F, Mariani L, Boni M, Tassi A, Stella P, Patiti M, Ermili F, Avenia N, Mariani E. Traditional lateral ileostomy versus percutaneous ileostomy by exclusion probe for the protection of extraperitoneal colo-rectal anastomosis: the ALPPI (Anastomotic Leak Prevention by Probe Ileostomy) trial. A randomized controlled trial. Eur J Surg Oncol. 2014;40(4):476–83
OP0286-HPR Resistance Exercise Improves Multidimensional Fatigue in Women with Fibromyalgia. A Randomized Controlled Trial
Authors: A. Ericsson, A. Palstam, A. Larsson, M. Löfgren, I. Bileviciute-Ljungar, J. Bjersing, B. Gerdle, E. Kosek, K. Mannerkorpi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Fibromyalgia (FM) affects approximately 1-3% of the general population. Fatigue limits the work ability as well as the social life of patients with FM. A few studies of physical exercise have included measures of fatigue in FM, indicating that exercise can decrease fatigue levels. There is limited knowledge about the effects of resistance exercise on multiple dimensions of fatigue in FM. <h3>Objectives</h3> To examine the effects of a person-centered progressive resistance exercise program on multiple dimensions of fatigue in women with FM, and to investigate predictors for the potential change in fatigue. <h3>Methods</h3> A total of 130 women with FM (age 22-64 years) were included in this assessor-blinded randomized controlled multi-center trial examining the effects of person-centered progressive resistance exercise compared with an active control group. The intervention was performed twice a week for 15 weeks. Outcomes were five dimensions of fatigue measured with the Multidimensional fatigue inventory (MFI-20). Information about background was gathered collected and the women also completed several health-related questionnaires. Multivariable stepwise regression was used to analyze predictors of change in fatigue in the total population. <h3>Results</h3> A higher improvement was found at the post-treatment examination for change in the resistance exercise group, as compared to change in the active control group for the MFI-20 subscales General fatigue (Resistance Δ-1.3 SD 3.1, Controls Δ-0.5 SD 2.6, p=0.031), Physical fatigue (Resistance Δ-1.7, SD 4.3, Controls Δ0.0, SD 2.7, p=0.013) and Mental fatigue (Resistance Δ-1.6 SD 3.4, Controls Δ-0.1 SD 2.5, p=0.008). Sleep efficiency was found to be the strongest predictor for change in the MFI-20 subscales General Fatigue (r<sub>s</sub> = -0.21, p=0.049) and for change in Reduced Motivation (r<sub>s</sub> = -0.22, p=0.037). Participating in resistance exercise (beta =1.90, p=0.010) and working less hours per week (beta =0.84, p=0.005) was independent significant predictors for change in Physical Fatigue (R<sup>2</sup>=0.14). Participating in resistance exercise was the strongest predictor for change in Mental Fatigue (p=0.008). <h3>Conclusions</h3> Person-centered progressive resistance exercise improved multiple dimensions of fatigue in women with FM when compared to an active control group. Participating in resistance exercise, reporting poorer sleep efficiency and working less hours per week at baseline predicted improvement in multidimensional fatigue in women with FM. <h3>Disclosure of Interest</h3> None declared
Lymphomatoid papulosis: response to treatment with recombinant interferon alfa-2b.
Authors: S J Proctor, G H Jackson, A L Lennard, J Marks
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.1.170 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1727920 Lymphomatoid papulosis: response to treatment with recombinant interferon alfa-2b. S J ProctorxS J ProctorSearch for articles by this author , G H JacksonxG H JacksonSearch for articles by this author , A L LennardxA L LennardSearch for articles by this author , J MarksxJ MarksSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.1.170 PDF "Lymphomatoid papulosis: response to treatment with recombinant interferon alfa-2b.." Journal of Clinical Oncology, 10(1), p. 170© 1992 by American Society of Clinical Oncology
Family history of panic disorder and hypersensitivity to CO2 in patients with panic disorder
Authors: G Perna, A Bertani, D Caldirola, L Bellodi
Journal: American Journal of Psychiatry (1996)

The authors investigated the relationships between hypersensitivity to CO2 and familial-genetic risk for panic disorder in patients with panic disorder.Morbidity risks for panic disorder were calculated for families of 203 patients with panic disorder, each of whom was challenged with 35% CO2.Patients who reacted with a positive response to the 35% CO2 challenge showed a genetic risk for panic disorder (morbidity risk = 14.4%) that was significantly higher than that for patients who did not react (morbidity risk = 3.9%).These findings support the idea that hypersensitivity to CO2 might be associated with a subtype of panic disorder specifically related to a greater familial loading.
OC-049 <b>A prospective comparison of safety and tolerability of propofol versus standard sedation for double balloon enteroscopy</b>–<b>time for a push forward?</b>
Authors: F Branchi, DS Sanders, D Turnbull, G Eapen, S Jankowski, R Sidhu
Journal: Gut (2015)

<h3>Introduction</h3> Double balloon enteroscopy (DBE) is routinely performed with moderate sedation in the UK. However, in comparison to standard endoscopy, DBE is complex and takes longer, therefore deep sedation with propofol could improve tolerability and feasibility of the test. <h3>Method</h3> All patients undergoing DBE between March13 and October14 were prospectively enrolled. DBE was performed either with administration of sedation with fentanyl and midazolam or with anaesthetist-assisted deep sedation with propofol, the decision being made on the basis of patients’ clinical history and expected length of the test. Data from patients receiving propofol were compared to those from patients receiving standard sedation during the same period. Patients were asked to fill in a questionnaire regarding their expectations before the test and their satisfaction afterwards. Anxiety, pain and discomfort were assessed by means of validated numeric rating scales (NRS, range 0–10). Data on comorbidities, previous surgery and hospital anxiety and depression scores (HADS) were also collected. The procedural characteristics of DBE were assessed. <h3>Results</h3> Twenty-one DBE (18 oral, 3 anal, 33% male) were performed with the aid of propofol infusion and 67 (54 oral, 13 anal, 51% male) with standard sedation. Mean age was 48 ± 14.3 in the propofol group and 58.6 ± 15.9 in the sedation group (p = 0.012). There were no other differences in demographics, comorbidities or HADS scores between the groups. The indications for DBE included obscure gastrointestinal bleeding (n = 45), Peutz-Jeghers syndrome (9) and suspected Crohn’s disease (20), small bowel tumour (10) or celiac complication (2). The mean dose of propofol administered was 1123 ± 483 mg. The mean doses of midazolam and fentanyl were 6 ± 3 mg and 118 ± 54 mcg respectively. No differences were observed in terms of diagnostic yield (52% vs 57%, p = ns) and therapeutic yield (33% both groups). Patients in the propofol group reported lower scores of pain (median score 0, IQR 0–0.5 vs 3, IQR 0–6, p &lt; 0.0001), discomfort (median 0, IQR 0–0.5 vs 3, IQR 1–7, p &lt; 0.0001) and distress (median 0, IQR 0–0 vs 1, IQR 0–5, p = 0.001) during the procedure. Whilst there were no complications in the propofol group, there was one episode of oxygen desaturation in the control group. <h3>Conclusion</h3> The use of propofol for DBE has a good safety profile and better patient tolerability and satisfaction in comparison with moderate sedation. It is associated with a high diagnostic and therapeutic yield. Its use should be recommended when the procedure is expected to be longer and technically challenging. <h3>Disclosure of interest</h3> None Declared.
Incidental Detection of Femoral Pseudoaneurysm at 18F-FDG PET/CT
Authors: Stephanie Nougaret, Monica Ragucci, Ariadne M. Bach, Gabriella Carollo, Lorenzo Mannelli
Journal: Clinical Nuclear Medicine (2015)

A 72-year-old man with history of lung cancer and melanoma was referred for routine follow-up with 18F-FDG PET/CT. CT images showed a new mass in the right groin associated with mild FDG activity on 18F-FDG PET images. Subsequent ultrasound obtained the same day demonstrated flow within the lesion to be a pseudoaneurysm of the right femoral artery.
THU0047 Autoantibody Profiling of Late and Early RA Patients Against Citrullinated Proteins
Authors: A. Lueking, P. Schriek, H. Goehler, M. Gamer, K. Marquart, A. Telaar, D. Chamrad, P. Schulz-Knappe, J. Richter, S. Vordenbaeumen, G.R. Burmester, M. Schneider
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The discovery of autoantibodies against citrullinated proteins (ACPA) and the consequent development of serological tests using cyclic citrullinated peptide (CCP) have improved diagnosis of rheumatoid arthritis (RA). ACPAs recognize specifically various citrullinated peptides that derive from different antigens. It has also been demonstrated that autoantibodies to different citrullinated peptides emerge at different stages of RA. However, by now the fine specificity against only a limited number of different peptides has been tested. <h3>Objectives</h3> To increase knowledge about ACPAs and their fine specificities in RA patients we aimed to identify novel citrullinated antigens and to characterize the ACPA profile in early and late RA. <h3>Methods</h3> 569 serum samples of CCP+ and CCP- RA patients with late RA, early RA or pre-RA and additional samples of volunteers and patients with early Arthritis (EA) but without RA at the time point tested have been analyzed in a multiplexed, bead-based, antigen array on the Luminex FlexMAP3D. Sera have been tested against a selection of 417 human proteins, including previously identified putative RA specific autoantigens and also known RA marker such as vimentin and fibrinogen. After coupling all proteins to individual color coded Luminex beads they were enzymatically citrullinated by peptidyl arginine deiminase and then tested against sera in the multiplex Luminex array. Complementarily all proteins were also measured in their native, unmodified form. <h3>Results</h3> We found novel citrullinated antigens targeted by ACPAs. The citrullinated antigens are highly reactive in mature RA whereas the unmodified proteins show only low reactivity. Generally, we observe an increase of the number of ACPA fine specificities with disease duration. In CCP negative tested RA patients, more than 10% of the patients recognize specifically several citrullinated antigens suggesting their diagnostic potential. <h3>Conclusions</h3> Novel citrullinated antigens targeted by ACPAs were identified. The identification of ACPA positive but CCP negative tested RA patients suggests that current CCP tests do not address the complete profile of ACPA fine specificities. Further studies are currently conducted to validate panels of citrullinated antigens in early RA patients. <h3>Disclosure of Interest</h3> A. Lueking Employee of: Protagen AG, P. Schriek Employee of: Protagen AG, H. Goehler Employee of: Protagen AG, M. Gamer Employee of: Protagen AG, K. Marquart Employee of: Protagen AG, A. Telaar: None declared, D. Chamrad Employee of: Protagen AG, P. Schulz-Knappe Employee of: Protagen AG, J. Richter: None declared, S. Vordenbaeumen: None declared, G. Burmester: None declared, M. Schneider: None declared
AB0996 Rheumathologic Diseases in Adolescence: Psychological Profile of a Difficult Age
Authors: M.C. Maggio, R. Riticella, G. Salvo, G. Corsello
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Chronic disease significantly interfere with the quality of life at every age, expecially in a period of life characterized by the need to assume a role in the society and the research of a specific identity. The personal image is often destroyed by the disease, the long term sequelae of pharmacological treatment. Adolescents are frequently obligated to quit many possibilities of experience with peers. <h3>Objectives</h3> We realized a plurispecialistic approach to adolescents with rheumatologic diseases, with the figures of neuropsychiatric, psychologists, rheumatologists, endocrinologists, to give an answer to the complex requests of these patients. <h3>Methods</h3> We evaluated 20 patients with rheumatologic diseases (JIA; SLE; Bechet Disease; Autoinflammatory syndromes…) and we used psychological tests as the Physique Anxiety Scale, the EAT-26, the CBCL 6-18, the CPRS and the F.R.T. (family relation test). <h3>Results</h3> All the patients were positive almost to one or more tests, with M:F ratio of 1:1 for anxiety scale. However psychosomatic diseases were more frequent in females, as eating disorders. Difficulties in social behaviour was more frequent in males, as the risk of drugs and alcohol abuse. <h3>Conclusions</h3> The specialist support and the psychological follow up helped our adolescents to win the difficulties of a chronic disease and gave them the chance to meet peers and share with them their troubles. <h3>Disclosure of Interest</h3> None declared
Improvement of Cerebral Glucose Metabolism in Symptomatic Patients With Carotid Artery Stenosis After Stenting
Authors: Hsien-Li Kao, Mao-Shin Lin, Wen-Chau Wu, Wen-Yih I. Tseng, Mao-Yuan Su, Ya-Fang Chen, Ming-Jang Chiu, Shan-Ying Wang, Wei-Shiung Yang, Kai-Yuan Tzen, Yen-Wen Wu, Ming-Fong Chen
Journal: Clinical Nuclear Medicine (2015)

Neurocognitive performance among patients with carotid artery stenosis or occlusion may deteriorate because of chronic cerebral hypoperfusion. Carotid artery stenting (CAS) has been reported to improve cerebral perfusion and neurocognitive function. The purpose of the study was to evaluate cerebral metabolism using F-fluorodeoxyglucose (FDG) positron emission tomography (PET) after CAS.Nineteen consecutive patients (15 men, 69 ± 13 years) with carotid artery stenosis or occlusion and cerebral ischemia detected on brain perfusion computed tomography (CT) or magnetic resonance imaging (MRI) were enrolled. Four patients had bilateral lesions, and 15 subjects had previous ischemic stroke. Neurocognitive function (NCF) assessments and brain FDG PET scans were performed before and 19 ± 7 (12-31) months after the procedure.The procedural success rate of CAS was 70%. Two patients were excluded from the study because of procedural complications. No new cerebral ischemic events or neurologic deaths occurred during follow-up of 44 ± 11 (15-54) months. Significant improvements were observed in the Mini-Mental State Examination (before, 26.06 ± 3.32 versus after, 28.13 ± 2.8; P = 0.0016), the verbal fluency test (26.81 ± 7.82 versus 30.75 ± 9.58; P = 0.0378), and marginal upgrading in the Alzheimer Disease Assessment Scale-Cognitive Subtest (7.19 ± 7.59 versus 5.63 ± 5.90; P = 0.0523). Six of 9 patients who underwent successful CAS showed improvement of cerebral glucose metabolism. Of the 4 patients with recanalization failure, 2 exhibited decline in ipsilateral glucose metabolism. Cerebral FDG metabolism improved in patients with successful CAS (P = 0.038), although there was a weak correlation between interval change of NCF tests and brain FDG metabolism.Successful CAS may improve long-term cerebral glucose metabolism and neurocognitive function in patients with chronic severe carotid stenosis or occlusion.
ECT, emergent dyskinesia, and depression
Authors: J A Flaherty, J Naidu, M Dysken
Journal: American Journal of Psychiatry (1984)

Three depressed patients developed a dyskinesia directly following ECT. In each case the dyskinesia improved some time after cessation of ECT. All patients had prior treatment with an antipsychotic drug and previous diagnoses of schizophrenia or schizoaffective disorder.
Readability of Online Patient Educational Resources Found on NCI-Designated Cancer Center Web Sites
Authors: Stephen A Rosenberg, David Francis, Craig R Hullett, Zachary S Morris, Michael M Fisher, Jeffrey V Brower, Kristin A Bradley, Bethany M Anderson, Michael F Bassetti, Randall J Kimple
Journal: Journal of the National Comprehensive Cancer Network (2016)

The NIH and Department of Health & Human Services recommend online patient information (OPI) be written at a sixth grade level. We used a panel of readability analyses to assess OPI from NCI-Designated Cancer Center (NCIDCC) Web sites.Cancer.gov was used to identify 68 NCIDCC Web sites from which we collected both general OPI and OPI specific to breast, prostate, lung, and colon cancers. This text was analyzed by 10 commonly used readability tests: the New Dale-Chall Readability Formula, Flesch Reading Ease scale, Flesch-Kinaid Grade Level, FORCAST scale, Fry Readability Graph, Simple Measure of Gobbledygook test, Gunning Frequency of Gobbledygook index, New Fog Count, Raygor Readability Estimate Graph, and Coleman-Liau Index. We tested the hypothesis that the readability of NCIDCC OPI was written at the sixth grade level. Secondary analyses were performed to compare readability of OPI between comprehensive and noncomprehensive centers, by region, and to OPI produced by the American Cancer Society (ACS).A mean of 30,507 words from 40 comprehensive and 18 noncomprehensive NCIDCCs was analyzed (7 nonclinical and 3 without appropriate OPI were excluded). Using a composite grade level score, the mean readability score of 12.46 (ie, college level: 95% CI, 12.13-12.79) was significantly greater than the target grade level of 6 (middle-school: P<.001). No difference between comprehensive and noncomprehensive centers was identified. Regional differences were identified in 4 of the 10 readability metrics (P<.05). ACS OPI provides easier language, at the seventh to ninth grade level, across all tests (P<.01).OPI from NCIDCC Web sites is more complex than recommended for the average patient.
Treatment strategies for "high-risk" leukemia.
Authors: E S Henderson
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.5.689 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3572461 Treatment strategies for "high-risk" leukemia. E S HendersonxE S HendersonSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.5.689 First Page PDF © 1987 by American Society of Clinical Oncology