ZINC METABOLISM IN HEPATIC DYSFUNCTION
Authors: B L VALLEE, W E WACKER, A F BARTHO LOMAY, F L HOCH
Journal: Annals of Internal Medicine (1959)

Article1 May 1959ZINC METABOLISM IN HEPATIC DYSFUNCTIONBERT L. VALLEE, M.D., WARREN E. C. WACKER, M.D., ANTHONY F. BARTHOLOMAY, SC.D., FREDERIC L. HOCH, M.D.BERT L. VALLEE, M.D., WARREN E. C. WACKER, M.D., ANTHONY F. BARTHOLOMAY, SC.D., FREDERIC L. HOCH, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-5-1077 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptZinc is present in all living organisms and is essential as a nutrient for plants and animals.13, 27The normal human dietary intake of zinc is about 10 to 15 mg. a day. The stool is the major excretory route; it contains about 10 mg. a day, whereas the urine contains only about 0.4 to 0.5 mg. a day.17The amount of zinc in different human organs varies between 10 and 200 μg. per gram of wet tissue.30The human liver contains 50 to 60 μg. of zinc per gram.34The identification of zinc as a component of carbonic anhydrase...Bibliography1. Bliss AF: Equilibrium between vitamin A alcohol and aldehyde in the presence of alcohol dehydrogenase, Arch. Biochem. 31: 197, 1951. CrossrefMedlineGoogle Scholar2. Bonnichsen RK: Crystalline animal alcohol dehydrogenase, Acta chem. Scand. 4: 715, 1950. CrossrefGoogle Scholar3. BownessMortonShakirStubbs JMRAMHAL: Distribution of copper and zinc in mammalian eyes. Occurrence of metals in melanin fractions from eye tissues, Biochem. J. 51: 521, 1952. CrossrefMedlineGoogle Scholar4. Ershoff BH: Conditioning factors in nutritional disease, Physiol. Rev. 28: 107-137, 1948. CrossrefMedlineGoogle Scholar5. GitlowBeyersColmore SEMRJP: Metabolism of iron. II. Intravenous iron tolerance tests in Laennec's cirrhosis, J. Lab. and Clin. Med. 40: 541-549, 1952. MedlineGoogle Scholar6. GublerLaheyAshenbruckerCartwrightWintrobe CJMEHGEMM: Studies on copper metabolism. I. Method for determination of copper in whole blood, red blood cells, and plasma, J. Biol. Chem. 196: 209-220, 1952. CrossrefMedlineGoogle Scholar7. HochVallee FLBL: Precipitation by trichloroacetic acid as a simplification in the determination of zinc in blood and its components, J. Biol. Chem. 181: 295-306, 1949. CrossrefMedlineGoogle Scholar8. HoekstraLewisPhillipsGrummer WGPKPHRH: Relationship of parakeratosis, supplemental calcium and zinc to zinc content of certain body components of swine, J. Animal Sc. 15: 752, 1956. CrossrefGoogle Scholar9. HolzerSchneider HS: Funktion der Leber-alkoholdehydrase, Angew. Chem. 67: 276, 1955. CrossrefGoogle Scholar10. KaegiVallee JHBL: Zur Bedeutung des Zinks im Stoffwechsel, Schweiz. med. Wchnschr. 88: 136, 1958. Google Scholar11. KeilinMann DT: Carbonic anhydrase. Purification and nature of the enzyme, Biochem. J. 34: 1163, 1940. CrossrefMedlineGoogle Scholar12. Klatskin G: Role of alcohol in pathogenesis of cirrhosis (Alpha Omega lecture), Yale J. Biol. and Med. 26: 23-37, 1953. MedlineGoogle Scholar13. LechartierBellamy GF: Sur la presence du zinc dans le corps des animaux et dans les vegetaux, Compt. rend. Acad. d. sc. 84: 687, 1877. Google Scholar14. LewisHoekstraGrummerPhillips PKWGRHPH: Effect of certain nutritional factors including calcium, phosphorus and zinc on parakeratosis in swine, J. Animal Sc. 15: 741-751, 1956. CrossrefGoogle Scholar15. LueckeHoeferBramwellThorp RWJAWSF: Mineral interrelations in parakeratosis of swine, J. Animal Sc. 15: 347-350, 1956. CrossrefGoogle Scholar16. LundegardhBergstrand HGH: Spectral-analytical investigations into the content of mineral substances in the liver, Nova acta Regiae societatis scientiarum upsaliensis, Series 4, V. 12, No. 3, 1940, Lundequistka, Uppsala, Sweden. Google Scholar17. McCanceWiddowson RAEW: The absorption and excretion of zinc, Biochem. J. 36: 692-696, 1942. CrossrefMedlineGoogle Scholar18. WohlGoodhart MGRS: Modern nutrition in health and disease: dietotherapy, 1955, Lea and Febiger, Philadelphia, p. 1066. Google Scholar19. NasonKaplanColowick ANOSP: Changes in enzymatic constitution in zinc-deficient neurospora, J. Biol. Chem. 188: 397, 1951. CrossrefMedlineGoogle Scholar20. NasonKaplanOldewurtel ANOHA: Further studies of nutritional conditions affecting enzymatic constitution in neurospora, J. Biol. Chem. 201: 435, 1953. CrossrefMedlineGoogle Scholar21. OlsenAnfinsen JACB: Crystallization and characterization of 1-glutamic dehydrogenase, J. Biol. Chem. 197: 67-79, 1952. CrossrefMedlineGoogle Scholar22. PatekHaig AJC: Occurrence of abnormal dark adaptation and its relation to vitamin A metabolism in patients with cirrhosis of liver, J. Clin. Investigation 18: 609-616, 1939. CrossrefMedlineGoogle Scholar23. Prabhu MB: Infantile cirrhosis of liver, Indian J. Pediat. 7: 122, 1940. CrossrefGoogle Scholar24. SmithPlumleeBeeson WHMPWM: Zinc requirement for growing swine, Science 128: 1280, 1958. CrossrefMedlineGoogle Scholar25. StevensonEarle JWIP: Studies on parakeratosis in swine, J. Animal Sc. 15: 1036, 1956. CrossrefGoogle Scholar26. TheorellBonnichsen HR: Studies on liver, alcohol dehydrogenase. I. Equilibria and initial reaction velocities, Acta chem. Scand. 5: 1105-1126, 1951. CrossrefGoogle Scholar27. ToddElvehjemHart WRCAEB: Zinc in the nutrition of the rat, Am. J. Physiol. 107: 146, 1934. CrossrefGoogle Scholar28. TuckerSalmon HFWD: Parakeratosis or zinc deficiency disease in pig, Proc. Soc. Exper. Biol. and Med. 88: 613, 1955. CrossrefMedlineGoogle Scholar29. Underwood EJ: Trace elements in human and animal nutrition, 1956, Academic Press, New York, p. 207. Google Scholar30. Vallee BL: The metabolic role of zinc, J. A. M. A. 162: 1053, 1956. CrossrefMedlineGoogle Scholar31. Vallee BL: Principles of quantitative biological emission spectrography, Symposium on spectrochemical analysis for trace elements, Special technical publication No. 221, 1958, American Society for Testing Materials, Philadelphia. CrossrefGoogle Scholar32. Vallee BL: Unpublished observations. Google Scholar33. ValleeAdelsteinOlson BLSJJA: Glutamic dehydrogenase of beef liver, a zinc metalloenzyme, J. Am. Chem. Soc. 77: 5196, 1955. CrossrefGoogle Scholar34. ValleeAltschule BLMD: Zinc in the mammalian organism, with particular reference to carbonic anhydrase, Physiol. Rev. 29: 370-388, 1949. CrossrefMedlineGoogle Scholar35. ValleeCoombsWilliams BLTLRJ: Spectrophotometric evidence for enzymatic zinc-inhibitor complexation, Federation Proc. 16: 264, 1957. Google Scholar36. ValleeGibson BLJG: Improved dithizone method for determination of small quantities of zinc in blood and tissue samples, J. Biol. Chem. 176: 435-443, 1948. CrossrefMedlineGoogle Scholar37. ValleeHoch BLFL: Zinc, a component of yeast alcohol dehydrogenase, Proc. Nat. Acad. Sc. 41: 327, 1955. CrossrefMedlineGoogle Scholar38. ValleeHoch BLFL: Zinc in horse liver alcohol dehydrogenase, J. Biol. Chem. 225: 185, 1957. CrossrefMedlineGoogle Scholar39. ValleeHochAdelsteinWacker BLFLSJWE: Pyridine nucleotide dependent metallodehydrogenases, J. Am. Chem. Soc. 78: 5879, 1956. CrossrefGoogle Scholar40. ValleeNeurath BLH: Carboxypeptidase, zinc metalloenzyme, J. Biol. Chem. 217: 253-261, 1955. CrossrefMedlineGoogle Scholar41. ValleeWackerBartholomayHoch BLWEAFFL: Zinc metabolism in hepatic dysfunction. II. Correlation of metabolic patterns with biochemical findings, New England J. Med. 257: 1055, 1957. CrossrefMedlineGoogle Scholar42. ValleeWackerBartholomayRobin BLWEAFED: Zinc metabolism in hepatic dysfunction. I. Serum zinc concentrations in Laennec's cirrhosis and their validation by sequential analysis, New England J. Med. 255: 403, 1956. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: BERT L. VALLEE, M.D.; WARREN E. C. WACKER, M.D.; ANTHONY F. BARTHOLOMAY, SC.D.; FREDERIC L. HOCH, M.D.*Received for publication January 16, 1959.Presented at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 2, 1958.From the Biophysics Research Laboratory and the Medical Clinic, Department of Medicine, Harvard Medical School and Peter Bent Brigham Hospital.†Supported by the Lasdon Fund, the Hartford Fund, the Rockefeller Foundation and the Howard Hughes Medical Institute.Requests for reprints should be addressed to Bert L. Vallee, M.D., Biophysics Research Laboratory of the Department of Medicine, Peter Bent Brigham Hospital, 721 Huntington Avenue, Boston 15, Massachusetts. 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