tbuckley/cabot-search huggingface dataset:
Designed by the food industry for wealth, not health: the ‘Eatwell Guide’
Authors: Zoe Harcombe
Journal: British Journal of Sports Medicine (2016)

The Balance of Good Health, a picture of a segmented plate, was launched by the UK Department of Health in 1994. In September 2007, this was relaunched by the Food Standards Agency as the Eatwell Plate. The changes were cosmetic. In March 2016, the Eatwell Plate was relaunched as the Eatwell Guide. Many of the changes were, again, cosmetic (figure 1).



Figure 1 
The Eatwell Guide.



The Eatwell Guide was formulated by a group appointed by Public Health England, consisting primarily of members of the food and drink industry rather than independent experts.

The Eatwell Plate became the Eatwell Guide; the knife and fork disappeared; the segment names were tweaked and the images on the plate became drawings, not photographs—looking even less like real food. None of this would have any impact on epidemics of obesity or type 2 diabetes.

The segment proportions changed: starchy foods increased from 33% to 38%; fruit and vegetables from 33% to 40%; ‘milk and dairy’ …
Abstract 359: Negative Regulation Of The Fgf-16 Gene Promoter By Doxorubicin Is Associated With A Decrease In Nkx2.5 Binding
Authors: Jie Wang, Yan Jin, Peter A Cattini
Journal: Circulation Research (2014)

Doxorubicin (DOX) is a widely used and effective anti-cancer drug, but it is also cardiotoxic, which can lead to heart failure, and so strategies are needed to protect the heart. Fibroblast growth factor 16 (FGF-16) is preferentially expressed and released from cardiomyocytes after birth. Evidence suggests that FGF-16 decreases the risk of heart damage and limits the negative effects of heart remodeling (hypertrophy and fibrosis) after injury in vivo. Exogenous addition of FGF-16 also increased resistance to the loss of contractility in an isolated heart model of acute DOX-induced injury. Thus, how endogenous FGF-16 production and by extension function is affected by DOX treatment is of interest. The FGF-16 gene is highly conserved between human and murine species. Alignment of sequences indicates a conserved Nkx2.5 binding site in the proximal promoter region that is associated with a previously characterized TATA box. Nkx2.5 is an important factor in vertebrate heart development and congenital disease. Furthermore, Nkx2.5 RNA levels are decreased with DOX treatment. Thus, the possibility that DOX negatively affects FGF-16, perhaps through an effect on Nkx2.5 levels or binding, was investigated. Neonatal rat cardiomyocytes were treated with DOX, and FGF-16 RNA levels decreased 75% within 6 hours as assessed by qPCR. Inhibition of transcription with actinomycinD had no effect on the DOX-induced decrease in FGF-16 RNA levels. Further support for an effect of DOX on FGF-16 transcription was obtained by transfection of cardiomyocytes with a hybrid 747 bp mouse FGF-16 promoter/luciferase reporter gene that was treated with DOX; a significant decrease in luciferase activity was observed. Electrophoretic mobility shift and chromatin immunoprecipitation assays suggest reduced Nkx2.5 protein-DNA interaction with this site after DOX treatment in vitro and in situ, respectively. These data indicate that DOX decreases FGF-16 RNA expression and this correlates with a decrease in Nkx2.5 levels and association with the proximal promoter region. A direct effect of Nkx2.5 on FGF-16 promoter activity awaits further testing. Thus, a decrease or loss of FGF-16 synthesis might contribute to the DOX-induced damage and/or response to injury.
Richard Humphry Thomas Ward
Authors: Tim Coltart
Journal: BMJ (2016)

Richard Humphry Thomas Ward (or “Humph,” as he was better known) was born in Croxley Green, Hertfordshire, the son of a consultant radiotherapist at Mount Vernon Hospital. After primary school he went to Shrewsbury School, where he excelled at rowing. He had the rare distinction of rowing in the first boat for three consecutive years and in 1955 was a member of the crew that won the Princess Elizabeth cup at Henley. The following year Humph went up to St John's College, Cambridge, to read natural sciences. He rowed for his college in the Lady Margaret first boat for all three years he was there, during which time he was awarded a university trial cap, being unlucky …
QOS-42QUALITY OF SURVIVAL AFTER BRAIN TUMOUR IN CHILDHOOD. DATA FROM A PSYCHOSOCIAL AND NEUROPSYCHOLOGICAL FOLLOW UP PROGRAM
Authors: Torhild Berntsen, Anne-Britt Skarbø, Antia Puhr, Kristine Stadskleiv, Stein Andersson
Journal: Neuro-Oncology (2016)

QOS-42. QUALITY OF SURVIVAL AFTER BRAIN TUMOUR IN CHILDHOOD. DATA FROM A PSYCHOSOCIAL AND NEUROPSYCHOLOGICAL FOLLOW UP PROGRAM Torhild Berntsen1, Anne-Britt Skarbo1, Antia Puhr1, Kristine Stadskleiv1, and Stein Andersson2; Oslo University Hospital, Oslo, Norway; University of Oslo, Oslo, Norway AIM: To investigate the impact on quality of life (QoL) of medical complications, adjuvant treatment, cognitive function, gender and age at diagnosis 5 or more years after the initial treatment for brain tumour in childhood. MATERIALS AND METHODS: 66 children were included, 41 girls and 25 boys, 43 with benign and 23 with malignant tumours. All have completed a comprehensive neuropsychological and psychosocial evaluation 5 years after end of treatment, included answering the questionnaire Pediatric Quality of Life Inventory (PedsQL), both children and parents. RESULTS: Children who had benign tumours, but who had medical complications after the initial operation (SC), reported significantly (p , 0.05) more problemscompared to thosewhohadanoperationonly (SO), onall PedsQLdimensions. Children who had adjuvant treatment (SA) reported significantly (p , 0.05) more problems compared to children who had surgery only on the physical, social, and school dimensions, but not on the emotional dimension on PedsQL. No significant differences were found between the groups with medical complications and adjuvant treatment. The parents’ ratings on PedsQL did not differ significantly from the children’s. There were no significant differences between the three groups with regards to IQ, age at diagnosis and gender. CONCLUSION: Having a childhood benign tumour that needs medical treatment after the operation, has a significant impact on quality of life, long after treatment is completed, equal to having a malignant tumour needing adjuvant treatment. Factors as IQ, gender and age at diagnosis are less influential. Neuro-Oncology 18:iii145–iii158, 2016. doi:10.1093/neuonc/now081.42 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
QOS-05AN ITALIAN NETWORK FOR THE NEUROCOGNITIVE AND PSYCHOLOGICAL FOLLOW-UP OF CHILDHOOD BRAIN TUMOR SURVIVORS
Authors: Geraldina Poggi, Marina Bertolotti, Claudia Corti, Simona Bellini, Daniele Bertin, Maura Massimino, Sonia Di Profio, MariaLuisa Garrè, Domitilla Elena Secco, Angela Mastronuzzi, Simonetta Gentile, Simone Gazzellini, Emanuela Russo, Elisa Petacchi, Elisabetta Viscardi, Maria Montanaro, Daniela Chieffo, Iacopo Sardi, Francesca Maffei
Journal: Neuro-Oncology (2016)
Metabolic Balance Studies of Oral Compounds in Severe Diabetes
Authors: H M WILKS, A R COLWELL
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human case of West Nile neuroinvasive disease in Portugal, summer 2015
Authors: Líbia Zé-Zé, Paula Proença, Hugo C Osório, Salomé Gomes, Teresa Luz, Paulo Parreira, Miguel Fevereiro, Maria João Alves
Journal: Eurosurveillance (2015)

A case of West Nile virus (WNV) infection was reported in the Algarve region, Portugal, in the first week of September 2015. WNV is known to circulate in Portugal, with occasional reports in horses and birds (2004 to 2011) and very sporadically human cases (in 2004 and in 2010). Here we present the clinical and laboratory aspects related to the first human case of West Nile neuroinvasive disease reported in Portugal.
High incidence of injury at the Sochi 2014 Winter Paralympic Games: a prospective cohort study of 6564 athlete days
Authors: W Derman, M P Schwellnus, E Jordaan, P Runciman, P Van de Vliet, C Blauwet, N Webborn, S Willick, J Stomphorst
Journal: British Journal of Sports Medicine (2016)

To describe the epidemiology of injuries at the Sochi 2014 Winter Paralympic Games.A total of 547 athletes from 45 countries were monitored daily for 12 days during the Sochi 2014 Winter Paralympic Games (6564 athlete days). Daily injury data were obtained from teams with their own medical support (32 teams, 510 athletes) and teams without their own medical support (13 teams, 37 athletes) through electronic data capturing systems.There were 174 total injuries reported, with an injury incidence rate (IR) of 26.5 per 1000 athlete days (95% CI 22.7% to 30.8%). There was a significantly higher IR recorded in alpine skiing/snowboarding (IR of 41.1 (95% CI 33.7% to 49.6%) p=0.0001) compared to cross-country skiing/biathlon, ice sledge hockey or wheelchair curling. Injuries in the shoulder region were the highest single-joint IR (IR of 6.4 (95% CI 4.6% to 8.6%)), although total upper and lower body IR were similar (IR 8.5 vs 8.4 (95% CI 6.4% to 11.1%)). Furthermore, the IR of acute injuries was significantly higher than other types of injury onset (IR of 17.8 (95% CI 14.7% to 21.4%)).In a Winter Paralympic Games setting, athletes report higher injury incidence than do Olympic athletes or athletes in a Summer Paralympic Games setting. The highest incidence of injury was reported in the alpine skiing/snowboarding sporting category. There was a similar incidence of injury in the upper and lower limbs. The joint with the greatest rate of injury reported was the shoulder joint. Our data can inform injury prevention programmes and policy considerations regarding athlete safety in future Winter Paralympic Games.
Case 27-1965
Authors: William F. McNeely, John B. Blennerhassett
Journal: New England Journal of Medicine (1965)

Presentation of Case First admission. A seventy-five-year-old woman was admitted to the hospital because of dyspnea.Twenty-nine years previously she had been confined to a sanatorium for six months because of pulmonary tuberculosis; thereafter, periodic x-ray examinations of the chest showed no evidence of active disease, and smears and cultures of the sputum were negative for acid-fast organisms. She had suffered from "asthma" since that time. Seven years before admission she underwent vaginal hysterectomy because of uterine prolapse; at that time the blood pressure was 220 systolic, 110 diastolic, and rales and rhonchi were heard over the upper portion of . . .
THE RELATIONSHIP OF RHEUMATOID FACTOR LEVELS WITH CORONARY ARTERY LESION COMPLEXITY AND SEVERITY IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE
Authors: Elnur Alizade, Anıl Avcı, Goksel Acar, Zeki Simsek, Lutfi Ocal, Mustafa Bulut, Muhammet Tellice, Mustafa Tabakcı, Halil Ibrahim Tanboga, Mustafa Akcakoyun, Ali Metin Esen
Journal: Journal of the American College of Cardiology (2014)
QOS-32EFFECT OF SEIZURE MORBIDITY ON NEUROCOGNITIVE OUTCOME, QUALITY OF LIFE, AND SOCIAL ATTAINMENT IN ADULT SURVIVORS OF CHILDHOOD CANCERS
Authors: Zsila Sadighi, Raja Khan, Jennifer Zabrowski, Chenghong Li, Tara Brinkman, Deo Kumar Srivastava, Les Robison, Melissa Hudson, Kevin Krull
Journal: Neuro-Oncology (2016)
A prospective survey of neuroleptic malignant syndrome in a short-term psychiatric hospital
Authors: A J Gelenberg, B Bellinghausen, J D Wojcik, W E Falk, G S Sachs
Journal: American Journal of Psychiatry (1988)

Of 1,470 patients treated with neuroleptics during 1 year at a private psychiatric hospital, only one patient developed neuroleptic malignant syndrome--an annual frequency of 0.07%. Use of low doses of neuroleptics may account for this frequency, which is below recent estimates.
Non-invasively differentiating extent of liver fibrosis by visualizing hepatic integrin αvβ3 expression with an MRI modality in mice
Authors: Feng Li, Huihui Yan, Jiyao Wang, Cong Li, Jian Wu, Shengdi Wu, Shengxiang Rao, Xihui Gao, Qu Jin
Journal: Biomaterials (2016)
Myeloproliferative and Lymphoproliferative Disorders in Tasmania: Reply
Authors: Graham G. Giles, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1985)

Myeloproliferative and Lymphoproliferative Disorders in Tasmania: Reply Graham G. Giles, Ph.D. Graham G. Giles, Ph.D. Victorian Cancer Registry Keogh House, 1 Rathdowne Street Carlton South, Australia 3053 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 75, Issue 1, July 1985, Page 177, https://doi.org/10.1093/jnci/75.1.177-a Published: 01 July 1985
Double-stem Hairpin Probe and Ultrasensitive Colorimetric Detection of Cancer-related Nucleic Acids
Authors: Jianguo Xu, Hongling Li, Zai-Sheng Wu, Jun Qian, Chang Xue, Lee Jia
Journal: Theranostics (2015)

The development of a versatile biosensing platform to screen specific DNA sequences is still an essential issue of molecular biology research and clinic diagnosis of genetic disease. In this work, we for the first time reported a double-stem hairpin probe (DHP) that was simultaneously engineered to incorporate a DNAzyme, DNAzyme's complementary fragment and nicking enzyme recognition site. The important aspect of this hairpin probe is that, although it is designed to have a long ds DNA fragment, no intermolecular interaction occurs, circumventing the sticky-end pairing-determined disadvantages encountered by classic molecular beacon. For the DHP-based colorimetric sensing system, as a model analyte, cancer-related DNA sequence can trigger a cascade polymerization/nicking cycle on only one oligonucleotide probe. This led to the dramatic accumulation of G-quadruplexes directly responsible for colorimetric signal conversion without any loss. As a result, the target DNA is capable of being detected to 1 fM (six to eight orders of magnitude lower than that of catalytic molecular beacons) and point mutations are distinguished by the naked eye. The described DHP as a-proof-of-concept would not only promote the design of colorimetric biosensors but also open a good way to promote the diagnosis and treatment of genetic diseases.
Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase
Authors: Xiaozhen He, Bin Yan, Shuang Liu, Jiantao Jia, Weiwei Lai, Xing Xin, Can-e Tang, Dixian Luo, Tan Tan, Yiqun Jiang, Ying Shi, Yating Liu, Desheng Xiao, Ling Chen, Shao Liu, Chao Mao, Gang Yin, Yan Cheng, Jia Fan, Ya Cao, Kathrin Muegge, Yongguang Tao
Journal: Cancer Research (2016)

Abstract Chromatin modification is pivotal to the epithelial–mesenchymal transition (EMT), which confers potent metastatic potential to cancer cells. Here, we report a role for the chromatin remodeling factor lymphoid-specific helicase (LSH) in nasopharyngeal carcinoma (NPC), a prevalent cancer in China. LSH expression was increased in NPC, where it was controlled by the Epstein–Barr virus-encoded protein LMP1. In NPC cells in vitro and in vivo, LSH promoted cancer progression in part by regulating expression of fumarate hydratase (FH), a core component of the tricarboxylic acid cycle. LSH bound to the FH promoter, recruiting the epigenetic silencer factor G9a to repress FH transcription. Clinically, we found that the concentration of TCA intermediates in NPC patient sera was deregulated in the presence of LSH. RNAi-mediated silencing of FH mimicked LSH overexpression, establishing FH as downstream mediator of LSH effects. The TCA intermediates α-KG and citrate potentiated the malignant character of NPC cells, in part by altering IKKα-dependent EMT gene expression. In this manner, LSH furthered malignant progression of NPC by modifying cancer cell metabolism to support EMT. Cancer Res; 76(19); 5743–55. ©2016 AACR.
Reply
Authors: Sheida Moghadamrad, Matteo Montani, Andrea De Gottardi
Journal: Hepatology (2013)

We appreciate the interest and the comments by Dr. Knisely about our work recently published in Hepatology,1 in which we propose that a newly described mutation in the ABCB11 gene may predispose to benign recurrent intrahepatic cholestasis through a regulatory mechanism at the lobular level. To adequately support this proposal, we examined the predicted pathogenicity of the c.221T>G mutation, which results in an amino acid change p.Ile74Arg in the first transmembrane domain. This mutation changes a weakly conserved amino acid and the physicochemical difference between Ile and Arg is moderate (Grantham score 97). In addition, this mutation could introduce a new splice acceptor site resulting in nonsense mediated messenger RNA (mRNA) decay. We agree that immunohistochemically assessed expression of other canalicular transporter homologs of bile salt export pump (BSEP) such as the products of ABCB4 or ABCC2 could have been tested. However, cholestasis with normal GGT does not occur typically in patients carrying these mutations. The additional immunohistochemical staining of this patient's liver using anti-ABCB4 (MDR3) antibodies did not show any zonal distribution of this protein (Fig. 1). Moreover, all coding sequences, including the flanking intron sequences of the ABCB4 and ATP8B1 genes, were analyzed without evidence for pathogenic mutations in this patient. Certainly we endorse the possibility of testing mutations of genes with products that specifically modulate the expression of wild-type BSEP,2 but in this case gene-profiling experiments going beyond the design of this clinical case would be needed. Furthermore, testing of affected family members would be helpful in determining whether cholestasis in this patient was due to the observed genetic change. In conclusion, based on the genetic and new immunohistochemical results obtained in this patient, we suggest that the c.221T>G mutation, possibly in combination with other abnormalities, can contribute to the pathogenesis of BRIC 2. We share, however, Dr. Knisely's opinion that caution is needed when interpreting immunohistochemical studies and we underscore the need for further investigation of the association between this mutation and BRIC 2. Sheida Moghadamrad, M.Sc.1 Matteo Montani, M.D.2 Andrea De Gottardi, M.D., Ph.D.1 1Department of Clinical Research Hepatology Study Group University of Berne, Berne, Switzerland 2Department of Pathology University of Berne, Berne, Switzerland
Massachusetts Department of Public Health
Authors: John C. Ayres, Roy F. Feemster
Journal: New England Journal of Medicine (1948)

For many years, the wood tick, officially known as the American dog tick, has been an annual nuisance on Cape Cod and Martha's Vineyard and inland from the South Shore. In recent years, a few cases of such tick-borne diseases as Rocky Mountain spotted fever and tularemia have been occurring in the same area.The Department was directed by Chapter 36 of the Resolves of 1948 to study the problem and seek to find ways by which the nuisance could be abated.It is important, in connection with this study, to know the geographic distribution of this tick (Dermacentor variabilis) . . .
Derivation and External Validation of a Prediction Rule for Five‐Year Mortality in Patients With Early Diffuse Cutaneous Systemic Sclerosis
Authors: Robyn T. Domsic, Svetlana I. Nihtyanova, Stephen R. Wisniewski, Michael J. Fine, Mary Lucas, C. Kent Kwoh, Christopher P. Denton, Thomas A. Medsger
Journal: Arthritis & Rheumatology (2015)

Although diffuse cutaneous systemic sclerosis (dcSSc) is associated with a reduction in life expectancy, there are no validated prognostic models for determining 5-year mortality in patients with dcSSc. The objective of this study was to derive and validate a rule for predicting 5-year mortality in patients with early dcSSc.We studied an inception cohort of 388 US Caucasian patients with early dcSSc (<2 years from the appearance of the first symptom). Predefined baseline variables were analyzed in a stepwise logistic regression model in order to identify factors independently associated with 5-year all-cause mortality. We rounded the beta weights to the nearest integer and summed the points assigned to each variable in order to stratify patients into low-risk (<0 points), moderate-risk (1-2 points), and high-risk (≥3 points) groups. We then applied this rule to an external validation cohort of 144 Caucasian patients with early dcSSc from the Royal Free Hospital cohort and compared stratum-specific 5-year mortality.Six independent predictors (rounded beta weight) comprised the model: age at first visit (points allotted: -1, 0, or 1), male sex (points allotted: 0 or 1), tendon friction rubs (points allotted: 0 or 1), gastrointestinal involvement (points allotted: 0 or 1), RNA polymerase III antibodies (points allotted: 0 or 1), and anemia (points allotted: 0 or 1). The 3-level risk stratification model performed well, with no significant differences between the US derivation cohort and the UK validation cohort.We derived and externally validated, in US and UK cohorts, an easy-to-use 6-variable prediction rule that assigns low-risk, moderate-risk, and high-risk categories for 5-year mortality in patients with early dcSSc. Only history, physical examination, and basic laboratory assessments are required.
Autologous bone marrow transplantation in high-risk remission B-lineage acute lymphoblastic leukemia using a cocktail of three monoclonal antibodies (BA-1/CD24, BA-2/CD9, and BA-3/CD10) plus complement and 4- hydroperoxycyclophosphamide for ex vivo bone marrow purging
Authors: FM Uckun, JH Kersey, R Haake, D Weisdorf, NK Ramsay
Journal: Blood (1992)
Reconstituted Tobacco—Smoking and Health Possibilities&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: H M Halter, T I Ito
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Reconstituted Tobacco—Smoking and Health Possibilities Get access Howard M. Halter, Howard M. Halter AMF Incorporated, Richmond, Virginia 23225 Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas I. Ito Thomas I. Ito AMF Incorporated, Richmond, Virginia 23225 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 6, June 1972, Pages 1869–1883, https://doi.org/10.1093/jnci/48.6.1869 Published: 01 June 1972