tbuckley/cabot-search huggingface dataset:
VANISHING MURMURS AND VENTRICULAR SEPTAL DEFECT
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations
Authors: A Madani, V Choukroun, J Soulier, V Cacheux, JF Claisse, F Valensi, S Daliphard, B Cazin, V Levy, V Leblond, MT Daniel, F Sigaux, MH Stern
Journal: Blood (1996)
Prospective evaluation of RT-PCR on sputum versus culture, urinary antigens and serology for Legionnaire's disease diagnosis
Authors: Elisabeth Botelho-Nevers, Florence Grattard, Alain Viallon, Séverine Allegra, Sophie Jarraud, Paul Verhoeven, Adrien Marcuccilli, Fréderic Lucht, Bruno Pozzetto, Philippe Berthelot
Journal: Journal of Infection (2016)
AB0259 Is Anti-CCP Positivity in Rheumatoid Arthritis Effected by Other Factors?
Authors: E. Ceceli, G. Demir, F. Ayhan, M. Aykut, A. Karagöz, P. Borman
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Anti-CCP antibodies are known to be related to more erosive disease in rheumatoid arthritis (RA). In recent years these antibodies are found to be increased in chronic obstructive pulmonary disease, liver disease, autoinflammatory diseases and cigarette smoking as well. <h3>Objectives</h3> In this study we searched whether additional factors such as lung, thyroid, liver problems and smoking had any contribution to anti-CCP levels in RA patients. <h3>Methods</h3> One hundred and thirteen RA patients who followed up in our rheumatology outpatient clinics participated in the study. In addition to demographic features, pulmonary function test results, anti thyroglobulin (anti TG ab) and anti thyro peroxidase (anti TPO ab) antibodies, hepatitis markers, erythrocyte sedimentation rate (ESR), C- reactive protein, rheumatiod factor (RF) and anti- CCP levels were evaluated. <h3>Results</h3> Mean values of the parameters were as follows: age of the patients: 54.76±11.56; disease duration: 10.9±7.2 years, forced expiratory volume 1: 79.5±21.33, forced vital capacity: 81.85±16.73. Levels of anti TG ab was high in 9.7% and that of anti TPO ab was high in 18.6% of the patients. 10% of the patients were Hepatitis B carrier. 72.6% of the patients were smoking cigarette. We divide the patients into 2 groups according to anti- CCP levels (higher or lower then 60 units). We found statistical significant difference in anti TG ab levels (p: 0.04), RF levels (p: 0.00) and ESR (p: 0.001). <h3>Conclusions</h3> It is well known that RF and ESR levels are related with anti- CCP levels, in addition to these we found anti TG antibodies could also increase anti -CCP levels. It is necessary to make studies with larger samples for more precise decisions. <h3>Disclosure of Interest</h3> None declared
FRI0249 IGAV Score – A Feasible Predictor of IGA Vasculitis Severity: Table 1
Authors: A. Hočevar, Ž. Rotar, A. Ambrožič, M. Plešivčnik Novljan, B. Lestan, S. Praprotnik, M. Tomšič
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> IgA vasculitis (IgAV) is commonly marginalized disease in adults. Clinical data are scarce and mostly limited to patients with significant renal disease. Predictors of severity in acute adult IgAV are unknown. <h3>Objectives</h3> To create a simple semi-quantitative score predicting the severity of adult IgAV and to aid the management of adult IgAV. <h3>Methods</h3> We performed a paper chart review of adult, histologically proven IgAV cases, diagnosed between 01.01.2010 and 31.12.2014 at our secondary/tertiary rheumatology center. The disease activity was assessed using BVAS-3. Predictors of severe disease were identified and an IgAV severity score (IgAVSS) was constructed. <h3>Results</h3> During the 60-month observation period, 129 new IgAV cases (58% male) were identified. The median (interquartile range (IQR), range) age was 64.2 (40.4–77.3, 18-92) years. Skin, gastrointestinal (GI), renal and joint involvement was present in 129 (purpura limited to lower limbs in 54.3% and generalized above waist in 45.7%), 48 (severe in 13), 65 (severe in 16) and 58 patients, respectively. Males and patients with generalized skin purpura had more severe disease (p=0.019 for male vs. female gender and p=0.0005 for generalized vs. limited purpura). Patients aged 45–75 years had more commonly severe GI and severe renal disease than younger (&lt;45) or older (&gt;75) ones (38.5% vs 31.6% vs 12.5% in case of severe GI disease and in 40.9% vs 9.5% vs 22.7% in case of severe renal disease respectively). The IgAVSS was constructed by assigning weights to patient age, gender and extent of purpura at presentation. It is a simple sum of the three domains (Table 1A). IgAVSS rendered good delineation between mild uneventful and severe IgAV when the cut off was set at ≥1.5 points. The difference in BVAS-3 between IgAVSS &lt;1.5 and IgAVSS ≥1.5 was significant, p=0.003. (Table 1B). <h3>Conclusions</h3> Gender, patient age and extent of purpura predict the severity of adult IgAV. We propose a semi quantitative score the IgAVSS which is calculated based on clinical characteristics only as a decision making aid to the physician in a busy outpatient clinic setting to distinguish patients who might have a more severe disease requiring hospital management from those who can be managed on the outpatient basis. <h3>Disclosure of Interest</h3> None declared
Bleomycin in nonseminomatous germ-cell tumors: cure rate versus morbidity.
Authors: E Cvitkovic
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.2.799 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9469373 Bleomycin in nonseminomatous germ-cell tumors: cure rate versus morbidity. E CvitkovicxE CvitkovicSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.2.799 PDF "Bleomycin in nonseminomatous germ-cell tumors: cure rate versus morbidity.." Journal of Clinical Oncology, 16(2), pp. 799–800© 1998 by American Society of Clinical Oncology
Adenocarcinoma of a colonic interposition graft for benign esophageal stricture in a young woman
Authors: Yi-Chiao Cheng, Chang-Chieh Wu, Chia-Cheng Lee, Cheng-Wen Hsiao, Tsai-Yu Lee, Shu-Wen Jao, Ching-Liang Ho
Journal: Endoscopy (2015)

There are more than 5000 cases of caustic ingestion in the United States annually [1]. About one-third of these patients subsequently develop esophageal strictures [2]. The colon has a good blood supply, is long enough to be pulled up to the neck, has a low incidence of disease, and is resistant to gastric secretions [3]. Therefore, it is usually the preferred source of tissue for esophageal replacement.
Book: Abortion in the USA and the UK
Authors: James Dixon
Journal: BMJ (2004)

The legitimacy or otherwise of induced abortion has been influenced by social, political, and medical perceptions. From the 13th century to the early 19th century induced abortion was legal under English common law, before the onset of quickening at 15 to 18 weeks gestation. However, to cause the death of an animate child in utero was considered homicide. The law changed fundamentally in 1803, making any attempt to induce an abortion at any gestation using a noxious or destructive substance a capital offence, largely because abortion was considered a major danger to women's health. Conversely, in the United States, where English common law still applied in many states, the first legislation to prohibit abortion at any gestation appeared in 1828 in New York state. At that time reports of 30% mortality among mothers after surgical abortion in hospital and 66% at the hands of non-medical practitioners were judged too high to allow the practice to continue. This legal position was atypical, as only five of 26 states had banned abortion by 1840.​1840.




Figure 1



Colin Francome

Ashgate, £35/$59.95, pp 188 ISBN 0 7546 3015 3 www.ashgate.com

Rating: ★★




Although abortion was an offence, the medical profession's use of abortion to safeguard maternal health was overlooked. As abortion became safer in the 20th century, demands grew for abortion laws to be liberalised. The British Abortion Act 1967 permitted abortions under proscribed conditions relating to maternal and fetal health and had a profound effect on subsequent extensions of abortion laws in over 40 countries between 1967 and 1982. A fundamental difference between the United States and United Kingdom is that US women have the right to abortion on request until fetal viability. Despite this difference there is little pressure to amend current legislation in Britain because women do not have difficulty obtaining abortion.

Ninety four per cent of abortions in the United Kingdom are done under clause C of the Abortion Act 1967, which permits termination under 24 weeks gestation on the grounds that termination is a relatively safe procedure and pregnancy is more dangerous than not being pregnant. One per cent are done because of fetal abnormality, and 1% because of medical complications in the mother. In 2000 the number of abortions per 1000 women of reproductive age was significantly higher in the United States (24.5) than in the United Kingdom (16.9). However, this difference may reflect the relative availability of contraception rather than the prevailing legislation.

Francome's appraisal of the circumstances that led to the current laws is enlightening. The views of pro-abortion factions and their opponents are explained, but evaluation of the ethical and moral dimensions is kept outside the scope of the book.
Substituting nonsomatic for somatic symptoms in the diagnosis of depression in elderly male medical patients
Authors: S R Rapp, S Vrana
Journal: American Journal of Psychiatry (1989)

The authors examined the sensitivity and specificity of a modified version of the Research Diagnostic Criteria (RDC) for major, minor, and intermittent depressive disorder in 150 elderly male medical inpatients. Four somatic RDC symptoms were replaced with four nonsomatic symptoms. The sensitivity of the modified criteria was 87%, the specificity was 97%, and 96% of patients were correctly classified. Misclassifications were of mildly depressed patients. These results provide empirical support for the use of alternative, nonsomatic depressive symptoms when somatic symptoms are ambiguous indicators of depression.
AB0029 Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis
Authors: P. Chalan, J. Bijzet, B.-J. Kroesen, E. Brouwer, M. Boots
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Precursor Th17 lineage cells expressing CD161 are implicated in rheumatoid arthritis pathogenesis. CD4+CD161+ T cells were found to accumulate in RA synovial fluid and tissue where they may acquire a non-classical T-helper 1 phenotype. The sole endogenous ligand for CD161 is lectin-like transcript 1 (LLT1). Previously, the LLT1-CD161 interaction was reported to co-stimulate T cell effector functions and to enhance IFN-γ production. This prompted us to investigate whether LLT1 is upregulated in the disease-affected joints. <h3>Objectives</h3> We investigated the presence and identity of LLT1-expressing cells in RA synovial fluid and synovial tissue. <h3>Methods</h3> Paired samples of peripheral blood and synovial fluid mononuclear cells (n=14) and digested synovial tissue cells (n=4) from late-stage rheumatoid arthritis patients were analyzed for LLT1 expression by flow cytometry. Paraffin-embedded synovial tissue sections (n=6) were used for the immunohistochemical detection of LLT1. <h3>Results</h3> In rheumatoid arthritis synovial fluid LLT1 expression was found upregulated in a subset of monocytes with a more differentiated, mature phenotype. In rheumatoid arthritis synovial tissue, LLT1-expressing cells were detected in the lining layer, sublining layer and in areas with lymphoid infiltrates. The LLT1 staining pattern resembled the pattern of CD68 staining. Flow cytometric analysis of digested synovial tissue confirmed LLT1 expression on CD68+ cells. <h3>Conclusions</h3> This is the first study showing that surface-expressed LLT1 is present at the site of local inflammation in RA. The finding of LLT1 expression by macrophages in synovial tissue suggests potential crosstalk with CD161+ T-cells. Ligation of CD161-LLT1 on CD4 T cells and macrophages respectively, may contribute to modulation of their function at the level of the joint. <h3>Disclosure of Interest</h3> None declared
Philippe Pinel (1745-1826)--liberator of the insane
Authors: S Y Tan, M E Yeow
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SP0088 Comparison of the Utility and Validity of Three Scoring Tools to Detect Skin Involvement in Patients with Juvenile Dermatomyositis: Table 1.
Authors: R. Campanilho-Marques
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile dermatomyositis (JDM) is a rare condition affecting 2-3 children/million/year. Muscle and skin involvement are key features. The muscle symptoms are frequently the main initial focus: formal measures (Childhood Myositis Assessment Scale - CMAS and Manual Muscle Testing of 8 groups - MMT8) exist to routinely and accurately assess this component of the disease. However the involvement of skin, and its assessment, is a vital aspect. The abbreviated Cutaneous Assessment Tool (CAT) encompassing active skin disease and skin damage, Disease Activity Score (DAS) and Myositis Intention to Treat Activity Index (MITAX), both with skin components, have all been suggested to measure skin disease in JDM; however the optimal tool is unknown. <h3>Objective</h3> To compare 3 tools for assessment of skin disease in JDM and correlate them with the physician9s 10cm skin visual analogue scale (VAS) in order to define which tool best assesses skin disease in patients with JDM. <h3>Methods</h3> Seventy-one patients recruited to the UK JDM Cohort &amp; Biomarker Study were included and assessed for skin disease using the CAT, DAS, MITAX and skin VAS. Markers of muscle disease (CMAS, MMT8, Creatine Kinase (CK) U/L), inflammatory markers (C-reactive protein (CRP) mg/L and Erythocyte sedimentation rate (ESR) mm/hr) and physician9s global VAS were recorded. Relationships were evaluated using Spearman9s correlations and predictors with linear regression. Inter-rater reliability was assessed using intra-class correlation coefficients. <h3>Results</h3> Of the 71 patients assessed 59.2% were female and 71.8% were Caucasian. At the time of assessment the mean (±SD) age was 9.8 (±3.8) years. The mean age at diagnosis was 6.6 (±3.4) years, and mean disease duration at time of assessment was 3.3 (±3.0) years. The skin section of the DAS had the strongest correlation with the skin VAS (DAS skin r<sub>s</sub>=0.79 p&lt;0.001, MITAX skin r<sub>s</sub>=0.60 p&lt;0.001 and CAT activity 0.63 p&lt;0.001) – Table 1. DAS skin and CAT Activity scores were both inversely correlated with both CMAS and MMT8 scores, but these correlations were moderate. MITAX skin was also correlated with the MMT8 score, but no significant correlation was noted with the CMAS. There were no significant correlations between CK and any of the tools. No significant correlations were found between the skin tools and the inflammatory markers, CRP and ESR. <h3>Conclusion</h3> This study demonstrates that the DAS skin section correlated the best with the skin VAS, used as the gold standard. The DAS skin tool was concise, quick to use and easy to score. <h3>Disclosure of Interest</h3> None declared
Allogeneic Hematopoietic Stem-Cell Transplantation (HSCT) in First Complete Remission Is Superior Compared to Chemotherapy/Autologous HSCT in Patients with Intermediate-Risk Cytogenetics Acute Myeloid Leukemia Lacking Mutations in NPM1, FLT3-ITD, and CEBPA: A Joint Study of AMLSG, Cetlam and Acute Leukemia Working Party of EBMT
Authors: Jordi Esteve, Myriam Labopin, Marta Pratcorona, Felicitas Thol, Salut Brunet, Michael Heuser, Gudrun Göhring, Arnold Ganser, Konstanze Döhner, Peter Paschka, Verena I. Gaidzik, Arnaud Pigneux, Gerard Socie, Jan J. Cornelissen, Michel Attal, Jean-Henri Bouhris, Johan Maertens, Didier Blaise, Mar Tormo, Josep-Maria Ribera, Marina Díaz-Beyá, Montserrat Hoyos, Jordi Sierra, Mohamad Mohty, Arnon Nagler, Hartmut Dohner, Richard F. Schlenk
Journal: Blood (2014)
Soundings: The new kids
Authors: Ricardo S Silva
Journal: BMJ (2000)

They came last Monday, just as the ones before them did—anxious, eager for all the knowledge we can give them in the four weeks they will spend with us. Are we ready for the challenge?

The sixth year students have a schedule for passing through the wards here at the hospital: 12 groups of about 15 students, distributed throughout the year, after which they are supposed to be ready for their final tests and they can rightly be called doctors (in training, but undeniably doctors).

And now we have the third group of the year with us, rubbing elbows with us on the morning rounds, eating in the cafeteria, discussing patients' conditions in the corridors, wanting badly to impress us, earn our respect, and prove themselves as equals in the appalling task of taking care of other people's lives. I must say that some of them have a real calling to become true doctors, to such an extent that it's not uncommon to hear complimentary remarks made about them—not, of course, in front of them.

But the reverse is also true. We are the object of their scrutiny, measured and weighed, and then we are either absolved or condemned according to very specific standards: knowledge (“Yes, Dr X knows a lot, but did you listen to Dr Y during last night's round? Brilliant”); bedside manners (“I thought that she was about to eat alive that patient who refused her medicine”); and sympathy (“We love Dr Z, she's such fun and so gentle.”) Sometimes when I walk along the ward I think that I can see the judges on both sides, eyeing the adversary and passing their final judgments.

Even if I have less contact with the students than my colleagues—other than responding to a request for a psychiatric evaluation on the ward—I make the most of the opportunities and try to learn from them. What do they need from me and my friends? What do they expect to achieve in the medical profession? If I were one of them—as I was 12 years ago— would I enjoy this phase of my education?

And, 12 years from now, will they care to remember us?
Teddy
Authors: Natalie Digate Muth
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Application of the Stage, Size, Grade, and Necrosis (SSIGN) Score for Clear Cell Renal Cell Carcinoma in Contemporary Patients
Authors: William P. Parker, John C. Cheville, Igor Frank, Harras B. Zaid, Christine M. Lohse, Stephen A. Boorjian, Bradley C. Leibovich, R. Houston Thompson
Journal: European Urology (2016)