tbuckley/cabot-search huggingface dataset:
Clofarabine in Pediatric Patients with Refractory or Relapsed Leukemia: the GATLA experience.
Authors: David Veron, Cecilia Riccheri, Monica Makiya, Luis Alberto Aversa, Marcela Gutierrez, Alcira Fynn, Virginia Schuttenberg, Alejandra Cédola, Constanza Drozdowski, Horacio Caferri, Julieta Bietti, Sergio Gomez, Graciela Onelda Elena, Guillermo Arbesu, Carlos Hollmann, Bibiana Tramunt, Mercedes Tomasetti, Sandra Zirone, Nestor Rossi, Daniel Freigeiro
Journal: Blood (2012)
Preclinical Immunogenicity Assessment of Baxter‘s Longer-Acting FVIII Candidate BAX 855 Using Novel Preclinical Models,
Authors: Frank M Horling, Sandra Schwele, Christian Lubich, Rafi U Ahmad, Markus Weiller, Margit Spatzenegger, Hans Peter Schwarz, Birgit M Reipert
Journal: Blood (2011)
Myeloid differentiation primary response 88 mutations in a distinct type of cutaneous marginal-zone lymphoma with a nonclass-switched immunoglobulin M immunophenotype
Authors: M. Wobser, K. Maurus, S. Roth, S. Appenzeller, G. Weyandt, M. Goebeler, A. Rosenwald, E. Geissinger
Journal: British Journal of Dermatology (2016)

Somatic mutations in the MYD88 gene are involved in the molecular pathogenesis of different subtypes of Non-Hodgkin B-cell lymphomas such as diffuse large B-cell lymphoma, lymphoplasmacytic lymphoma and Waldenstrom′s macroglobulinemia1. Albeit with much lower frequency, the key driver mutation MYD88 (c.794T>C, p.L265P) has also been identified in non-cutaneous marginal zone lymphomas and chronic lymphocytic leukemia. The increasing knowledge about such molecular aberrations and their consecutive biological effects has already been implemented within the clinical routine.

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P0787 : Comparison of sofosbuvir +/- simeprevir in heterogeneous, real-world populations of HCV patients over 70 years of age vs younger HCV patients; Data from the Trio network
Authors: N. Tsai, K. Kowdley, B. Bacon, S. Flamm, E. Lawitz, S. Milligan, Z. Younossi, D. Dieterich
Journal: Journal of Hepatology (2015)
Low Incidence of CMV Reactivation and Infectious Morbidity and Mortality after Nonmyeloablative Haploidentical Bone Marrow Transplantation Incorporating Post-Transplantation Cyclophosphamide.
Authors: Heather J. Symons, Xiaobu Ye, Leo Luznik, Michele Phelps, Angelita Crawford, M. Yair Levy, Richard J. Jones, Ephraim J. Fuchs
Journal: Blood (2005)
The Impact of the Child with Thalassemia On the Family: Parental Assessment by Child Health Questionnaire.
Authors: Robert Yamashita, Amy Sobota, Felicia Trachtenberg, Yan Xu, Zahra Pakbaz, Isaac Odame, Alexis A. Thompson, Dru Foote, Dorothy A. Kleinert, Patricia J Giardina, Charles T. Quinn, Janet L Kwiatkowski, Ellis J Neufeld, Leann Schilling, Jeanne Boudreaux
Journal: Blood (2009)
Mechanisms of Diminished Attention to Eyes in Autism
Authors: Jennifer M. Moriuchi, Ami Klin, Warren Jones
Journal: American Journal of Psychiatry (2016)

Two hypotheses, gaze aversion and gaze indifference, are commonly cited to explain a diagnostic hallmark of autism: reduced attention to others' eyes. The two posit different areas of atypical brain function, different pathogenic models of disability, and different possible treatments. Evidence for and against each hypothesis is mixed but has thus far focused on older children and adults. The authors evaluated both mechanistic hypotheses in two sets of experiments at the time of initial diagnosis.Eye-tracking data were collected in 86 2-year-olds: 26 with autism, tested at initial diagnosis; 38 matched typically developing children; and 22 matched developmentally delayed children. In two experiments, the authors measured response to direct and implicit cueing to look at the eyes.When directly cued to look at the eyes, 2-year-olds with autism did not look away faster than did typically developing children; their latency varied neither categorically nor dimensionally by degree of eye cueing. Moreover, direct cueing had a stronger sustained effect on their amount of eye-looking than on that of typically developing children. When presented with implicit social cues for eye-looking, 2-year-olds with autism neither shifted their gaze away nor more subtly averted their gaze to peripheral locations.The results falsify the gaze aversion hypothesis; instead, at the time of initial diagnosis, diminished eye-looking in autism is consistent with passive insensitivity to the social signals in others' eyes.
Intact Apoptosis Signaling In Pediatric ALL Xenograft Leukemia Is Associated with Favorable Patient Outcome, Prolonged NOD/SCID Engraftment and Low Expression of Anti-Apoptotic Molecules
Authors: Manon Queudeville, Felix Seyfried, Sarah Mirjam Eckhoff, Klaus-Michael Debatin, Lueder Hinrich Meyer
Journal: Blood (2010)
Abstract 14745: Acute Post-ischemic GPER1 Activation Protects the Myocardium Against Ischemia/Reperfusion Injury by Reducing Mitochondrial Protein Ubiquitination, Histone Acetylation and Calpain10 levels and Inhibition of the mPTP Opening
Authors: Yansheng Feng, Mohammad E. Kabir, Cesar Humberto Hernandez, Bjorn Olde, Fredrik Leeb-Lundberg, Jean C. Bopassa
Journal: Circulation (2015)

Introduction: We recently found that acute pre-ischemic estrogen-induced cardioprotection against ischemia/reperfusion injury was mainly mediated via G protein-coupled estrogen receptor1 (GPER1) activation but not through classical estrogen receptors: alpha (ERα) and beta (ERβ). Hypothesis: We investigated whether acute post-ischemic estrogen (PI-E2) treatment can also induce cardioprotective effect via GPER1 activation in the intact animal subjected to ischemia/reperfusion injury. Methods: Male and ovarectomized female Sprague-Dawley rats were anesthetized with ketamine (80 mg/kg i.p.) and xylazine (8 mg/kg i.p.). Hearts were subjected to 35 min of the left anterior descending (LAD) artery occlusion, followed by 180 min reperfusion. An E2 bolus (50 mg/kg body weight) or PBS (same volume) was applied via the femoral vein 5 min before reperfusion and a GPER1 antagonist, G15, was given 10 min before E2. Area at risk (AAR) was identified using Evans Blue dye and myocardial infarct size assessed by TTC staining method. Mitochondria calcium retention capacity (CRC) required to induce mitochondrial permeability transition pore (mPTP) opening was assessed after 10 min reperfusion. Expression levels of ubiquitinated; histone acetylated; calpains 1 and 10 proteins were measured by Western Blot in mitochondrial and cytosolic fractions. Results: We found that PI-E2 treatment reduced myocardial infarct size normalized to the AAR or the whole LV and improved mitochondrial CRC. PI-E2 treatment reduced protein histone acetylation in mitochondrial but not in cytosolic fractions, decreased mitochondrial proteins ubiquitination and also decreased calpain1 and calpain10 levels in cytosolic and mitochondrial fractions as compared to control, respectively. Interestingly, all these of E2 effects were abolished by addition of G15. Conclusion: Acute post-ischemic GPER1 activation by estrogen induces cardioprotection against ischemia/reperfusion injury. PI-E2 effects through GPER1 involve the reduction of the level of mitochondrial protein histone acetylation, ubiquitination, calpain1 and calpain10. This PI-E2-GPER1 effect is associated with the inhibition of the mPTP opening.
Effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing and health‐related quality of life measures in heart failure patients with preserved ejection fraction and pulmonary hypertension
Authors: Licette C.Y. Liu, Yoran M. Hummel, Peter van der Meer, Rolf M.F. Berger, Kevin Damman, Dirk J. van Veldhuisen, Adriaan A. Voors, Elke S. Hoendermis
Journal: European Journal of Heart Failure (2016)
Phosphoramide Mustard (PM) Population Pharmacokinetics to Estimate Inter-Individual Variability in Exposure and Identify Clinical Factors Associated with Variability in Reduced Intensity Conditioning (RIC) Hematopoietic Stem Cell Transplant (HCT) Patients
Authors: Kinjal Sanghavi, Anthony C. Wiseman, Mark Kirstein, Richard Brundage, Pamala A. Jacobson
Journal: Blood (2014)
Multiple Myeloma: Multiplying Therapies
Authors: Susan E. Bates
Journal: Clinical Cancer Research (2016)

Multiple myeloma must have among the most, if not the most, FDA approvals for any one malignancy. If the four liposomal doxorubicin approvals are counted separately, there are 21 FDA approvals ([1][1]). Such a list is remarkable and does not include combinations of these agents. The 5-year survival
Long-Term Survival after HLA-Haploidentical Stem Cell Transplantation from Non-Inherited Maternal Antigen-Mismatched Family Donors: Impact of Chronic Graft-Versus-Host Disease.
Authors: Tatsuo Ichinohe, Chihiro Shimazaki, Motohiro Hamaguchi, Arata Watanabe, Hiroyuki Ishida, Takao Yoshihara, Akira Morimoto, Nobuhiko Uoshima, Souichi Adachi, Takeshi Inukai, Akihisa Sawada, Koji Oka, Mitsuru Itoh, Masayuki Hino, Junya Kanda, Takashi Uchiyama, Yoshihisa Kodera
Journal: Blood (2007)
Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview
Authors: Mathieu P. Rodero, Yanick J. Crow
Journal: The Journal of Experimental Medicine (2016)

Type I interferon is a potent substance. As such, the induction, transmission, and resolution of the type I interferon–mediated immune response are tightly regulated. As defined, the type I interferonopathies represent discrete examples of a disturbance of the homeostatic control of this system caused by Mendelian mutations. Considering the complexity of the interferon response, the identification of further monogenic diseases belonging to this disease grouping seems likely, with the recognition of type I interferonopathies becoming of increasing clinical importance as treatment options are developed based on an understanding of disease pathology and innate immune signaling. Definition of the type I interferonopathies indicates that autoinflammation can be both interferon and noninterferon related, and that a primary disturbance of the innate immune system can “spill over” into autoimmunity in some cases. Indeed, that several non-Mendelian disorders, most particularly systemic lupus erythematosus and dermatomyositis, are also characterized by an up-regulation of type I interferon signaling suggests the possibility that insights derived from this work will have relevance to a broader field of clinical medicine.
Pulmonary immune responses against Aspergillus fumigatus are characterized by high frequencies of IL-17 producing T-cells
Authors: Hetty Jolink, Renate de Boer, Pleun Hombrink, René E. Jonkers, Jaap T. van Dissel, J.H. Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Journal of Infection (2016)
Recurrent SETBP1 Mutations in Atypical Chronic Myeloid Leukemia Abrogate an Ubiquitination Site and Dysregulate SETBP1 Protein Levels
Authors: Carlo Gambacorti-Passerini, Simona Valletta, Nils Winkelmann, Sara Redaelli, Roberta Spinelli, Alessandra Pirola, Laura Antolini, Luca Mologni, Carla Donadoni, Elli Papaemmanuil, Susanne Schnittger, Kim Dong-Wook, Jacqueline Boultwood, Fabio Rossi, Giuseppe Gaipa, Greta De Martini, Paola Francia di Celle, Hyun G. Jang, Valeria Fantin, Graham R Bignell, Vera Magistroni, Torsten Haferlach, Enrico Maria Pogliani, Peter Campbell, Andrew J Chase, William J Tapper, Nicholas C.P. Cross, Rocco Piazza
Journal: Blood (2012)
Receptor Repertoire Reconstitution Suggests Acquisition of Patient-Specific Tolerance by Natural Killer Cells Arising from Hematopoietic Progenitor Stem Cells after Haploidentical Transplantation.
Authors: Luca Vago, Simona Di Terlizzi, Elisabetta Zino, Chiara F. Magnani, Maria T. Lupo Stanghellini, Zulma Magnani, Benedetta Mazzi, Daniela Clerici, Attilio Bondanza, Marco Bregni, Silvano Rossini, Jacopo Peccatori, Chiara Bonini, Fabio Ciceri, Claudio Bordignon, Katharina Fleischhauer
Journal: Blood (2005)
C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection
Authors: Kenji Toyonaga, Shota Torigoe, Yoshitomo Motomura, Takane Kamichi, Jennifer M. Hayashi, Yasu S. Morita, Naoto Noguchi, Yasushi Chuma, Hideyasu Kiyohara, Kazuhiro Matsuo, Hiroshi Tanaka, Yoshiko Nakagawa, Tetsushi Sakuma, Masaki Ohmuraya, Takashi Yamamoto, Masayuki Umemura, Goro Matsuzaki, Yasunobu Yoshikai, Ikuya Yano, Tomofumi Miyamoto, Sho Yamasaki
Journal: Immunity (2016)
Skewing of the T Cell Receptor Gene Repertoire and Public Clonotypes in Cytotoxic T Cells of Patients with Chronic Idiopathic Neutropenia: A Role for Antigen Selection in Disease Development
Authors: Evangelia Stalika, Michalis Spanoudakis, Nikos Darzentas, Maria Karypidou, Achilles Anagnostopoulos, Semeli Mastrodimou, Kostas Stamatopoulos, Helen Papadaki
Journal: Blood (2012)
Treatment of Steroid Resistant Grade II to IV Acute Gvhd by Infusion of Mesenchymal Stroma Cells Expanded with Human Plasma and Platelet Lysate - a Phase I/II Study
Authors: Liane CJ te Boome, Caroline A Lindemans, Ineke Slaper-Cortenbach, Henk Rozemuller, Eefke J Petersen, Jaap Jan Boelens, Marc Bierings, Nico Wulffraat, Jurgen Kuball
Journal: Blood (2011)
Combination of Sorafenib and 5-Azacytidine Has Significant Activity in Patients with Relapsed/Refractory or Untreated Acute Myeloid Leukemia and FLT3-ITD mutation
Authors: Farhad Ravandi, Mona Lisa Alattar, Mark J. Levis, Guillermo Garcia-Manero, Mary A Richie, Naval G. Daver, Stefan Faderl, Michael Andreeff, Gautam Borthakur, Jan A. Burger, Tapan M. Kadia, Michael R. Grunwald, Sara E Dellasala, Jorge E. Cortes, Hagop M. Kantarjian
Journal: Blood (2012)
Third Party Umbilical Cord Blood Regulatory T Cells Prevents Graft Versus Host Disease In a Xenogenic Murine Model.
Authors: Shawndeep Tung, William Decker, Simon Robinson, Nina Shah, Sherry Klumpp, Stephens Clifton, Marina Konopleva, Guillermo Garcia-Manero, Laurence Cooper, Elizabeth J. Shpall, Simrit Parmar
Journal: Blood (2010)
Long-Term Prognostic Value of Cardiac Magnetic Resonance in Left Ventricle Noncompaction
Authors: Daniele Andreini, Gianluca Pontone, Jan Bogaert, Alberto Roghi, Andrea Barison, Juerg Schwitter, Saima Mushtaq, Georgios Vovas, Paola Sormani, Giovanni D. Aquaro, Pierre Monney, Chiara Segurini, Marco Guglielmo, Edoardo Conte, Laura Fusini, Antonio Dello Russo, Massimo Lombardi, Paola Gripari, Andrea Baggiano, Cesare Fiorentini, Federico Lombardi, Antonio L. Bartorelli, Mauro Pepi, Pier Giorgio Masci
Journal: Journal of the American College of Cardiology (2016)
Differentiation of selves: Differentiating a fuzzy concept
Authors: Andreas Mojzisch, Thomas Schultze, Joachim Hüffmeier, Stefan Schulz-Hardt
Journal: Behavioral and Brain Sciences (2016)

Abstract Notwithstanding the appeal of the “one size fits all” approach that Baumeister et al. propose, we argue that there is no panacea for improving group performance. The concept of “differentiation of selves” constitutes an umbrella term for similar seeming but actually different constructs. Even the same type of “differentiation of selves” can be beneficial for some and harmful for other tasks.
The Combination of Tacrolimus (T), Sirolimus (S), and Rabbit Anti-Thymocyte Globulin (Thymoglobulin Thymo) to Prevent Acute Graft-Vs-Host Disease (aGVHD) in Patients (pts) Receiving Unrelated Hematopoietic Stem Cell Transplantation (UHSCT).
Authors: Zaid S Al-Kadhimi, Zartash Gul, Lawrence G. Lum, Lois Ayash, Muneer H. Abidi, Wei Chen, Alice Mitchell, Voravit Ratanatharathorn, Joseph Uberti
Journal: Blood (2009)
Melphalan-Prednisone-Thalidomide (MP-T) Demonstrates a Significant Survival Advantage in Elderly Patients ≥75 Years with Multiple Myeloma Compared with Melphalan-Prednisone (MP) in a Randomized, Double-Blind, Placebo-Controlled Trial, IFM 01/01.
Authors: Cyrille Hulin, Thierry Facon, Philippe Rodon, Brigitte Pegourie, Lotfi Benboubker, Chantal Doyen, Mamoun Dib, Gael Guillerm, Laurent Voillat, Claire Mathiot, Philippe Casassus, Olivier Decaux, Michel Flesch, Laurent Garderet, Philippe Moreau
Journal: Blood (2007)
AB0188 Effect of Smoking on Joint Damage and Disease Activity in Patients with Rheumatoid Arthritis
Authors: F. Sivas, F.G. Yurdakul, A. Kılıcaslan, S. Duran, B. Baskan, H. Bodur
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> It is known that smoking is a poor prognostic factor for the development of rheumatoid arthritis (RA) and other inflammatory rheumatic diseases. According to our knowledge in Turkish population there are no studies about effects of smoking on joint damage and disease activity of RA patients. <h3>Objectives</h3> In this study, we investigated the relationship between smoking with disease activity and radiological damage in Turkish patients with RA. <h3>Methods</h3> The study included 165 patients with RA. Patients9 demographics, disease duration, age at onset, drugs, rheumatoid factor (RF) levels, anti- Cyclic Citrullinated Peptide (a- CCP) levels and smoking habits recorded. Morning stiffness duration, tender and swollen joint count (TJC, SCJ), pain with using visual analog scale (VAS pain), patient and physician global assessment (PGA, PhGA), Health assessment questionnaire (HAQ) evaluated. Disease activity score 28 (DAS 28) calculated. All patients in the study examined for lung involvement and 127 patients standard hand radiographs evaluated using modified Sharp method. <h3>Results</h3> Mean disease duration was 139.4±96.4 months. Patients were divided into 3 groups according to smoking habits. Ninety nine (60%) patients were never smoker, 45 (27.3%) patients were long-term smoker (more than 2 years), and 21 (12.7%) patients were new smoker (2 or less years). While the groups were similar in terms of age and disease duration, male gender was more in long-term smokers. Three groups compared for disease activity. DAS 28 scores were 3.2±1.2; 3.2±1.3; 3.2±1.4 respectively (p&gt;0.05). The erosion score (2.6±5.8; 7.1±10.9; 11.1±19.2 respectively) and joint space narrowing score (9.9±7.3; 18.6±14.9; 17.3±12.3 respectively) according to modified Sharp method were significantly lower in never smokers group than other groups (p&lt;0.05). RF titrations were 55.2±58.9; 84.9±71.5; 60.5±63.1; and long- term smokers group was significantly higher than the other groups (p&lt;0.05). Likewise RF titration was higher in ≥20 pack-years smokers than the other patients (never smokers and &lt;20 pack-years smokers). There was no relationship between a-CPP levels with smoking and joint damage (p&gt;0.05). <h3>Conclusions</h3> Although smoking known as a poor prognostic factor in RA, there was no correlation between disease activity and smoking in our population. On the other hand, less radiographic damage has been found in never smoker group. Although cigarette smoking does not appear to correlate with disease activity may be effective in the long-term joint damage. <h3>Disclosure of Interest</h3> None declared
HOXB7 Is Critically Involved in Multiple Myeloma-Induced Angiogenic Switch.
Authors: Paola Storti, Gaetano Donofrio, Marina Bolzoni, Simona Colla, Irma Airoldi, Valentina Sgobba, Manuela Abeltino, Katia Todoerti, Luca Agnelli, Mirca Lazzaretti, Cristina Mancini, Sabrina Bonomini, Domenico Ribatti, Vito Pistoia, Antonino Neri, Vittorio Rizzoli, Nicola Giuliani
Journal: Blood (2009)
SP0119 Systematic Reviews and Meta-Analyses for Dummies: A Tutorial on How, When, and Why To Get Started
Authors: R. Christensen
Journal: Annals of the Rheumatic Diseases (2016)

The world today is overflowing with results from trials to the point where anyone can be overwhelmed. Being able to sort out the good systematic reviews and meta-analyses from the bad ones and then be confident in the ability to judge the quality of the evidence is critical. Systematic reviews (i.e., the process of systematically locating and synthesizing data from completed studies) and meta-analyses (i.e., the statistical component of a systematic review) are the procedures that make it possible to synthesize data from a series of studies (i.e., evidence synthesis); these are essential to summarise evidence relating to efficacy and safety of health care interventions accurately and reliably. The process begins with a pre-specified protocol [1] asking an explicit question, in terms of the populations, alternative management strategies (an intervention, sometimes experimental and a comparator, sometimes standard care), and all patient-important outcomes [2]. After the evidence is collected, summarised, and reported [3], a good systematic review will help determine the quality of evidence based on study design, risk of bias, imprecision, inconsistency, indirectness, and magnitude of effect [4]. Quality of the evidence (QoE) reflects our confidence that the estimates of the effect are correct. High QoE: “<i>We are very confident that the true effect lies close to that of the estimate of the effect</i>” (no more research needed); Very low QoE: “<i>The true effect is likely to be substantially different from the estimate of effect</i>” [5]. Following this, guideline panels might conclude with either a strong or conditional recommendation, either for or against an intervention - indicating whether patients should receive the specific course of action {6}. <h3>References</h3> Shamseer L, et al. PRISMA-P Group. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015 Jan 2;349:g7647. Guyatt G, et al. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J Clin Epidemiol. 2011 Apr;64(4):383–94. Liberati A, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009 Aug 18;151(4):W65–94. Balshem H, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011 Apr;64(4):401–6. Christensen R, et al. Do “Evidence-Based Recommendations” Need to Reveal the Evidence? Minimal Criteria Supporting an “Evidence Claim”. J Rheumatol. 2015 Oct;42(10):1737–9. Christensen R &amp; Hart LE. Evidence-Based Guideline: ACR made 10 strong treatment recommendations for RA, but high-quality evidence was sparse. Ann Intern Med. 2016 Mar 15;164(6):JC27. <h3>Disclosure of Interest</h3> None declared