tbuckley/cabot-search huggingface dataset:
Distribution of Cancer Mortality Among Ethnic Subgroups of the White Population of New York City, 1953–58<xref ref-type="fn" rid="FN1">2</xref>
Authors: Vaun A. Newill, M.D.
Journal: JNCI Journal of the National Cancer Institute (1961)

Data on 84,341 deaths of white residents in New York City occurring in the years 1953–58 and attributed to malignant neoplasm were examined with respect to nativity status and religion. Comparison was with estimates of the religious distribution of the population of the city and with a 2 percent sample of deaths from all causes in 1955. After age adjustment, total mortality rates from all neoplastic disorders were similar in the native-born and foreign-born populations, and differences between religious groups were not remarkable. Rates for the foreign-born and native-born for specific sites of malignant neoplasm showed relatively small differences. Data were not available to enable examination of cancer-mortality rates according to specific country of birth of the foreign-born. Most striking were the differences in rates of mortality from individual sites of neoplasm between the Jewish group and the Catholic and Protestant groups. Among males, cancers of the buccal cavity and pharynx, esophagus, gall-bladder, larynx, lung, prostate, skin (other than melanoma), and other male genitalia were appreciably less common in the Jewish group than in either of the other religious groups. In females, cancer of the cervix uteri showed the same pattern. Certain sites exhibited higher rates in the Jewish group. These included cancers of the large intestine, kidney, brain, and thyroid, and melanoma, reticulum-cell sarcoma, lymphosarcoma, Hodgkin's disease, other lymphoma, and leukemia. Cancer of the male breast and, among females, cancers of the liver and pancreas, were also more common among the Jewish group. With some minor modifications, these patterns according to religion were seen in both the native-born and foreign-born populations.
Efficacy and feasibility of preoperative chemotherapy for elderly patients with stage II / III esophageal cancer
Authors: Takahairo Miyamoto, Tetsuji Terazawa, Masahiro Gotoh, Takayuki Kii, Hitoshi Nishitani, Shin Kuwakado, Fukutaro Shimamoto, Ken Asaishi, Hajime Kawai, Kazuhide Higuchi
Journal: Annals of Oncology (2015)
Reducing Malaria Parasite Load in Donated Blood
Authors: M. J. Friedrich
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous Rupture of a Normal Spleen
Authors: Hyman Duby
Journal: New England Journal of Medicine (1945)

ALTHOUGH it is difficult to accept the idea that the normal spleen can rupture under normal physiologic conditions, a relatively small number of cases of seemingly proved authenticity have been reported in the surgical literature during the last twenty years.There are various theories adopted to substantiate spontaneous rupture of the spleen. Susman1 has summed up the process of spontaneous rupture as follows: softening of all structures of the spleen; congestion of the portal vein and its radicles and inability of the narrower splenic vein to accommodate itself, blood thus being forced between the spleen and investing peritoneum, which finally . . .
Rapid immunohistochemical analysis of pancreatic cytology from endoscopic ultrasound-guided fine-needle aspirates: A prospective clinical trial.
Authors: Susan Tsai, Paul S. Ritch, Beth Erickson, Ben George, Fabian McCartney Johnston, Alexander C. Mackinnon, Douglas B. Evans, Kathleen K. Christians
Journal: Journal of Clinical Oncology (2016)

400 Background: Acquisition of pancreatic cancer (PC) tissue specimens from endoscopic ultrasound-guided fine needle aspirates (EUS-FNA) is crucial to investigational pancreatic cancer trials seeking to utilize molecular profile directed therapy. Methods: In an ongoing prospective clinical trial we have utilized molecular profiling of EUS-FNA specimens from patients with resectable and borderline resectable pancreatic cancers. Cytologic specimens were evaluated for six biomarkers to guide the choice of neoadjuvant therapy: secreted protein acid rich in cysteine (SPARC), thymidylate synthase (TYMS), ribonucleotide reductase M1 (RRM1), human equilibrative nucleoside transporter 1 (ENT1), excision repair cross-complementing 1 (ERCC), and topoisomerase 1 (TOPO). Final immunohistochemical (IHC) interpretation was scored by a single pathologist using both staining intensity and percent immunochemically reactive cells. Results: The trial has enrolled 99 patients to date; 47 (47%) resectable patients and 52 (52%) borderline resectable patients. No patient experienced a EUS-FNA related complication. IHC profiling was reported in a median of 5 business days (IQR:3). Of the 99 patient samples, 73 (74%) had adequate cellularity for IHC profiling and this was not affected by stage of disease (n = 35, resectable; n = 38 borderline resectable; p = 0.82). Analysis of SPARC expression was limited to specimens with adequate stromal cells for analysis (n = 50, 51%). Among the 73 patients with adequate tissue for profiling, expression profiling was interpreted to be favorable for the following therapeutic agents: nab-paclitaxel, (SPARC, n = 35, 48%), 5-fluorouracil (TYMS, n = 68, 93%), gemcitabine (RRM1, n = 34, 47%; ENT1, n = 38, 52%), platinum agents (ERCC, n = 30, 41%), and irinotecan (TOPO, n = 62, 85%). Conclusions: The use of EUS-FNA specimens for molecular diagnostics is feasible and IHC analysis was possible in 74% of patient specimens, with preservation of stromal components in over 50%. Further refinement of molecular techniques may expand the breadth of analysis which may be performed, to include quantitative polymerase chain reaction and genetic sequencing Clinical trial information: NCIT01726582.
Asparagine Depletion, Safety and Antibody Production after E Coli Asparaginase Treatment in Children with Newly Diagnosed Acute Lymphoblastic Leukaemia Treated with EORTC 58951 Protocol: A Single Center Report.
Authors: Yves Bertrand, Marie Pierre Goutagny, Anne Lise Poulat, Sandrine Girard, Cecile Acquaviva, Christine Vianey Saban, Claudine Vermot-Desroches, Laurence Bourdin, Cedric Alex, Eric Rougemond, Kamila Kebaili
Journal: Blood (2007)
PD1-3-7: High ERCC1 expression correlates with poor survival in lung adenocarcinoma
Authors: Mee Sook Roh, Akihiko Yoshizawa, Junya Fukuoka, Konstantin Shilo, Takeshi Fujii, Teri J. Franks, Stephen M. Hewitt, Jin Jen, William D. Travis
Journal: Journal of Thoracic Oncology (2007)
Transaortic endoscopic ultrasound-guided fine-needle aspiration of a positron emission tomography-positive abdominal para-aortic lymph node
Authors: Domenico Galasso, Mihai Rimbaş, Fabia Attili, Filippo Lococo, Alberto Larghi
Journal: Endoscopy (2015)

Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is an important diagnostic tool for the evaluation of lesions affecting the gastrointestinal tract and adjacent organs [1]. Major vessels serve as procedural landmarks and provide an anechoic interface that allows the clear visualization of nodes/masses on the opposite side. Major vessels have for several decades been a target of interventional radiology; however, interposition of the aorta between the EUS probe and a target lesion has been considered a contraindication to EUS-FNA.
Commentary on “Participation of p53 Protein in the Cellular Response to DNA Damage”
Authors: Michael B. Kastan
Journal: Cancer Research (2016)

See related article by Kastan et al., [Cancer Res 1991;51:6304–11][1] .

Visit the Cancer Research 75th Anniversary [timeline][2].

The focus of the DNA damage and repair field prior to 1991 was largely on mechanisms by which environmental carcinogens (e.g., aromatic hydrocarbons, ultraviolet
Lenvatinib treatment of advanced RAI-refractory differentiated thyroid cancer (DTC): Cytokine and angiogenic factor (CAF) profiling in combination with tumor genetic analysis to identify markers associated with response.
Authors: Douglas Wilmot Ball, Steven I. Sherman, Barbara Jarzab, Maria E. Cabanillas, Renato Martins, Manisha H. Shah, Donald Bodenner, Kate Newbold, Lisa F. Licitra, Duncan Topliss, Roger Allison, Tadashi Kadowaki, Yasuhiro Funahashi, Mark Matijevic, Pallavi Sachdev, James P. O'Brien, Martin Schlumberger
Journal: Journal of Clinical Oncology (2012)

5518 Background: Lenvatinib is an oral tyrosine kinase inhibitor targeting VEGFR1-3, FGFR1-4, RET, KIT and PDGFRβ. In a phase II study of lenvatinib, 58 patients (pts) with DTC were enrolled and a response rate of 50% was observed (Sherman, ASCO 2011). Methods: Pts received lenvatinib at a starting dose of 24 mg oral once daily in 28-day cycles. Serum was collected at baseline (BL), on day 8 and on day 36 and concentrations of 47 CAFs were measured using multiplex bead arrays and enzyme-linked immunosorbent assay (ELISA). 33 genes (443 mutations) were examined in archival tumor tissues (n=25). Association of baseline CAF, changes in CAF levels upon treatment and gene mutation status with treatment outcomes was investigated. Results: Combination of low baseline VEGF and ANG-2 (p=0.02 and HR=0.386) correlated with longer PFS. Both baseline and changes in CAF levels demonstrated an association with gene mutation status. High baseline levels of VEGF were observed in pts with wild type RAS and BRAF (p=0.035) whereas high baseline sTIE-2 levels associated with RAS mutation (p=0.023). Supporting pre-clinical mouse xenograft tumor model developed using ANG2-overexpressing human thyroid cancer cell line FTC-286 demonstrated reduced sensitivity to lenvatinib treatment. Increased levels of IL-10 and FGF-2 8-day post-treatment (8d post-tx) significantly associated with RAS (N- or K-) and BRAF mutation. Combination of gene mutation status with baseline CAF levels provided better prediction of longer PFS compared to gene mutation alone. Hierarchical clustering modeling using changes in CAF levels 8d post-tx with tumor shrinkage identified a set of CAFs that could predict two categories of lenvatinib response: longer PFS and greater tumor shrinkage or longer PFS in the absence of significant tumor shrinkage. Conclusions: CAF profiling identified potential predictive biomarkers of lenvatinib treatment outcomes in DTC. Combination of RAS and BRAF mutation with baseline VEGF and ANG-2 or treatment-associated changes in FGF-2 and IL-10 level correlated with lenvatinib treatment response.
Body Ultrasonography
Authors: Joseph T. Ferrucci
Journal: New England Journal of Medicine (1979)

(First of Two Parts)SINCE the introduction of gray-scale signal processing in 1974, B-scan sonography has become a widely accepted method for noninvasive imaging of nearly all abdominal and pelvic viscera. Results in varied clinical settings have proved sonography an accurate, versatile and inexpensive technic yielding high-resolution cross-sectional tomographic images with negligible risk or discomfort.Useful diagnostic contributions of high-frequency ultrasound imaging had been demonstrated several years earlier for special problems in obstetrics, cardiology and ophthalmology. However, broader clinical applications awaited the advent of the wide-dynamic-range (gray-scale) display for enhanced texture information of solid parenchymatous organs. Concomitant advances in transducer . . .
Mast-Cell Neoplasia in Mice
Authors: Margaret K. Deringer, Thelma B. Dunn
Journal: JNCI Journal of the National Cancer Institute (1947)

Mast-Cell Neoplasia in Mice Margaret K. Deringer, Margaret K. Deringer biologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn Thelma B. Dunn pathologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 289–298, https://doi.org/10.1093/jnci/7.4.289 Published: 01 February 1947 Article history Published: 01 February 1947 Received: 04 February 1947
Thrombosis Protection In Klkb1-/- (Prekallikrein KO) Mice Is Mediated By Increased Renal Mas Receptor, Plasma Prostacyclin, and Aortic Sirt1
Authors: Chao Fang, Evi Stavrou, Yunmei Wang, Nadja Grobe, Daniel I. Simon, Alvin H. Schmaier
Journal: Blood (2013)
Cytotoxicity and DNA Crosslinks Produced by Mitomycin Analogs in Aerobic and Hypoxic EMT6 Cells
Authors: S R Keyes, R Loomis, M P DiGiovanna, C A Pritsos, S Rockwell, A C Sartorelli
Journal: Cancer Communications (1991)

Several mitomycin antibiotics were evaluated for their capacities to kill EMT6 tumor cells and to produce DNA crosslinks under conditions of oxygenation and hypoxia. The agents examined included mitomycin C, porfiromycin, and the 7-aminomethyl dithioacetal derivative of mitomycin C (BMY-43324), all of which caused greater kill of hypoxic cells than of their oxygenated counterparts; the N,N'-dimethylaminomethylene derivative of mitomycin C (BMY-25282), which was considerably more cytotoxic under oxygenated conditions than in hypoxia; and the N,N'-dimethylaminomethylene derivative of porfiromycin (BL-6783), which was equal in its toxicity to hypoxic and oxygenated cells. All of these agents produced DNA crosslinks in EMT6 cells, as measured by alkaline elution. The number of crosslinks required to produce a given amount of cell kill was similar, regardless of the mitomycin employed or the degree of oxygenation, suggesting that the crosslinking of DNA was a major lesion in the cytodestructive action of the mitomycins.
The TRPA1 ion channel is expressed in CD4+ T cells and restrains T-cell-mediated colitis through inhibition of TRPV1
Authors: Samuel Bertin, Yukari Aoki-Nonaka, Jihyung Lee, Petrus R de Jong, Peter Kim, Tiffany Han, Timothy Yu, Keith To, Naoki Takahashi, Brigid S Boland, John T Chang, Samuel B Ho, Scott Herdman, Maripat Corr, Alessandra Franco, Sonia Sharma, Hui Dong, Armen N Akopian, Eyal Raz
Journal: Gut (2016)

Transient receptor potential ankyrin-1 (TRPA1) and transient receptor potential vanilloid-1 (TRPV1) are calcium (Ca2+)-permeable ion channels mostly known as pain receptors in sensory neurons. However, growing evidence suggests their crucial involvement in the pathogenesis of IBD. We explored the possible contribution of TRPA1 and TRPV1 to T-cell-mediated colitis.We evaluated the role of Trpa1 gene deletion in two models of experimental colitis (ie, interleukin-10 knockout and T-cell-adoptive transfer models). We performed electrophysiological and Ca2+ imaging studies to analyse TRPA1 and TRPV1 functions in CD4+ T cells. We used genetic and pharmacological approaches to evaluate TRPV1 contribution to the phenotype of Trpa1-/- CD4+ T cells. We also analysed TRPA1 and TRPV1 gene expression and TRPA1+TRPV1+ T cell infiltration in colonic biopsies from patients with IBD.We identified a protective role for TRPA1 in T-cell-mediated colitis. We demonstrated the functional expression of TRPA1 on the plasma membrane of CD4+ T cells and identified that Trpa1-/- CD4+ T cells have increased T-cell receptor-induced Ca2+ influx, activation profile and differentiation into Th1-effector cells. This phenotype was abrogated upon genetic deletion or pharmacological inhibition of the TRPV1 channel in mouse and human CD4+ T cells. Finally, we found differential regulation of TRPA1 and TRPV1 gene expression as well as increased infiltration of TRPA1+TRPV1+ T cells in the colon of patients with IBD.Our study indicates that TRPA1 inhibits TRPV1 channel activity in CD4+ T cells, and consequently restrains CD4+ T-cell activation and colitogenic responses. These findings may therefore have therapeutic implications for human IBD.
Polymorphism Profile of Nine Short Tandem Repeat Loci in the Han Chinese
Authors: Shuangding Li, Chunxia Yan, Yajun Deng, Ruilin Wang, Jian Wang, Huanming Yang, Shengbin Li
Journal: Genomics Proteomics & Bioinformatics (2003)

Abstract Nine short tandem repeat (STR) markers (D3S1358, VWA, FGA, THO1, TPOX, CSFIPO, D5S818, D13S317, and D7S820) and a sex-identification marker (Amelogenin locus) were amplified with multiplex PCR and were genotyped with a four-color fluorescence method in samples from 174 unrelated Han individuals in North China. The allele frequencies, genotype frequencies, heterozygosity, probability of discrimination powers, probability of paternity exclusion and Hardy-Weinberg equilibrium expectations were determined. The results demonstrated that the genotypes at all these STR loci in Han population conform to Hardy-Weinberg equilibrium expectations. The combined discrimination power (DP) was 1.05×10−10 within nine STR loci analyzed and the probability of paternity exclusion (EPP) was 0.9998. The results indicate that these nine STR loci and the Amelogenin locus are useful markers for human identification, paternity and maternity testing and sex determination in forensic sciences.
Primidone Thrombocytopenia
Authors: WILLIAM A. PARKER
Journal: Annals of Internal Medicine (1974)

Letters1 October 1974Primidone ThrombocytopeniaWILLIAM A. PARKER, PHARM. D.WILLIAM A. PARKER, PHARM. D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-81-4-559 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Primidone-induced hematologic reactions are generally quite rare. As discussed by Booker (1), primidone has been implicated in producing folic acid deficiency and megaloblastic anemia after continual administration. Hemorrhagic disease of newborns and leukopenia have also been reported (1), but rarely, and Rozbicka (2) has reported one patient with thrombocytopenic purpura. In general, authors reporting on large series of patients have commented on the relative immunity of the bone marrow to adverse effects of primidone. The following case report describes a primidone-induced thrombocytopenia.The patient was a 26-year-old white woman with major motor seizures and a history of...References1. BOOKER H: Primidone toxicity, in Antiepileptic Drugs, edited by WOODBURY DM, PENRY JK, SCHMIDT RP. New York, Raven Press, 1972 Google Scholar2. ROZBICKA H: Przypadek małopłytkowości po stosowaniu leku przeciwpadaczkowego mysoliny. Neurol Neurochir Pol 2:655-657, 1968 MedlineGoogle Scholar3. TIMBERLAKEABBOTTSCHWAB WJR: Mysoline: effective anticonvulsant with initial problems of adjustment. N Engl J Med 252:304-307, 1955 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: WILLIAM A. PARKER, PHARM. D.Affiliations: College of Pharmacy Dalhousie University Halifax, Nova Scotia, Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPrimidoneAnticonvulsant drugs and hematological diseaseIdiosyncratic Adverse Reactions to Antiepileptic DrugsPhenytoin-Induced ThrombocytopeniaAdverse Effects 1 October 1974Volume 81, Issue 4Page: 559-560KeywordsBone marrowEpileptic seizuresFolic acidImmunityMegaloblastic anemia ePublished: 1 December 2008 Issue Published: 1 October 1974 PDF downloadLoading ...
The Multiplication Principle as the Basis for Concentrating Urine in the Kidney
Journal: Journal of the American Society of Nephrology (2001)

Originally published as "Das Multipikationsprinzip als Grundlage der Harnkonzentrierung in der Niere", in Zeitschrift für Elektrochemie und angewandte physikalische Chemie 55(6):539-558, 1951.
Giant Cutaneous Papilloma of the Shoulder
Authors: S D GREENBERG, S A WALLACE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Identification of factors promoting ex vivo maintenance of mouse hematopoietic stem cells by long-term single-cell quantification
Authors: Konstantinos D. Kokkaliaris, Erin Drew, Max Endele, Dirk Loeffler, Philipp S. Hoppe, Oliver Hilsenbeck, Bernhard Schauberger, Christoph Hinzen, Stavroula Skylaki, Marina Theodorou, Matthias Kieslinger, Ihor Lemischka, Kateri Moore, Timm Schroeder
Journal: Blood (2016)