tbuckley/cabot-search huggingface dataset:
THU0446 Different Distribution and Activation Degree of TH17 CD4+ Cells in Peripheral Blood in Patients with Osteoarthritis, Rheumatoid Arthritis and Healthy Donors: Preliminary Results of the Magenta Clicao (Clinical Cell Analisys in Osteoarthritis) Study
Authors: A. Lurati, A. Laria, K.A. Re, M. Marrazza, D. Mazzocchi, M. Scarpellini
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteoarthritis (OA) as well as rheumatoid arthritis (RA) are chronic diseases associated with joint destruction and mobility impairment. Data about changes in immune system in RA and the significant role of T cells, primarily Th17 cells, are now well recognised. On the other hand data about immunological profile in OA are limited, because OA has long been regarded in the past as a non inflammatory disease. <h3>Objectives</h3> Our study aim to measure the distribution and the activation degree of CD4+ Tlymphocites and primarily of Th17 in peripheral blood of OA, RA and age-matched healthy controls. <h3>Methods</h3> Patients with established diagnosis of RA according to ACR/EULAR 2010 criteria, knee or hipbOA according to ACR criteria and volunteers healthy blood donors were eligible. Other inclusion criteria were: DAS28 between 3.2 and 5.1 or a WOMAC Likert score more than 50 respectively, age between 40 to 60 years old, Kelgren Lawrence index of 2-3. Exclusion criteria were the presence of other autoimmune diseases, tumors or secondary osteoarthritis. Finally no changes in rheumatologic drugs were allowed from 3 months before enrolment. Multi-channel flow cytometry and monoclonal antibodies against CD3, CD4, CD8, CCR6 CD38 CXCR3 and HLA DR were used to distinguish and quantificate T cells subpopulation. Participants were informed about the aim of the project and gave their written consent. The Local Ethic Committee accepted the project. <h3>Results</h3> We analysed blood samples of 131 subjects (75 females, 56 males). 55 Patients with well defined RA, 56 with hip or knee OA and 20 healthy controls age matched. Mean age was 45±2.7 years old (p&gt;0.05 between groups). Blood samples from RA patients had significantly higher count of CD4+CD38+DR+ (activated CD4 T cells) and Th17 (CCR6+CXCR3-) cells as compared to OA patients and control group (P&lt;0.01). Furthermore the samples from the OA patients had an higher percentage of activated CD4 T cells and Th17 cells as compared to control group (P&lt;0.05). Interesting there was no difference between Th1 (CD4+CXCR3+CCR6-) and Th2 (CD4+CXCR3-CCR6-) between the three groups (P&gt;0.1) <h3>Conclusions</h3> According to the latest view of OA disease pathogenesis, our preliminary results give support to the hypothesis that OA may also be a disease with an immunological/inflammatory involvement like RA. In fact it seems that there is a quantitative but non qualitative difference in Th17 cells profile, including the expression of activation markers, between RA and OA. <h3>Disclosure of Interest</h3> None declared
A memorable patient: Cyril
Authors: Penny Harding
Journal: BMJ (2003)

Cyril was the last patient at the end of a busy clinic in Leicester, and he came into my room with his daughter. He was an octogenarian with a smart appearance, an upright stance, and a military looking moustache. I just happened to say “Do I detect a slight Welsh accent?” and the response to this casual question has led to three years of an association that has given us both much unexpected pleasure.
Corticosteroid Injections for Sciatica
Authors: J D Pritikin
Journal: New England Journal of Medicine (1997)

Objective.To determine the effectiveness and predictors of response to lumbar epidural corticosteroid injections (ESI) in patients with sciatica.We performed a 12-month, multicentre, double-blind, randomized, placebo-controlled, parallel-group trial in four secondary pain-care clinics in the Wessex Region.Methods.Two hundred and twenty-eight patients with a clinical diagnosis of unilateral sciatica of 1-18 months' duration were randomized to either three lumbar ESIs of triamcinolone acetonide or interligamentous saline injections at intervals of 3 weeks.The main outcome measure was the Oswestry low back pain disability questionnaire (ODQ).Results.At 3 weeks, the ESI group demonstrated a transient benefit over the placebo group (patients achieving a 75% improvement in ODQ, 12.5 vs 3.7%; number needed to treat, 11.4).No benefit was demonstrated from 6 to 52 weeks.ESIs did not improve physical function, hasten return to work or reduce the need for surgery.There was no benefit of repeated ESIs over single injection.No clinical predictors of response were found.At the end of the study the majority of patients still had significant pain and disability regardless of intervention.Conclusions.In this pragmatic study, ESIs offered transient benefit in symptoms at 3 weeks in patients with sciatica, but no sustained benefits in terms of pain, function or need for surgery.Sciatica is a chronic condition requiring a multidisciplinary approach.To fully investigate the value of ESIs, they need to be evaluated as part of a multidisciplinary approach.
Case 31-1968
Authors: Caesar Briefer, Benjamin Castleman
Journal: New England Journal of Medicine (1968)

Presentation of CaseA seventy-seven-year-old woman was admitted to the hospital because of pain in the back and fever.Twenty-two years previously osteomyelitis of the left great toe had necessitated transmetatarsal amputation. Subsequently, she was found to have diabetes, which was treated with diet and insulin. She was well thereafter until four days before entry, when there was the onset of weakness of the legs and severe pain in the mid-lumbar area, without radiation to the legs or feet. The function of the bowel and bladder was not affected. She had a cough productive of small amounts of sputum, accompanied . . .
AACR Meeting Highlights Diversity In a Time of Integration
Authors: J. Mccann
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article AACR Meeting Highlights Diversity In a Time of Integration Get access Jean Mccann Jean Mccann Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 10, 18 May 1994, Pages 743–746, https://doi.org/10.1093/jnci/86.10.743 Published: 18 May 1994
AB0161 The Topoisomerase I Inhibitor Irinotecan and the Tyrosyl-DNA Phosphodiesterase 1 Inhibitor Furamidine Synergistically Suppress Murine Lupus Nephritis
Authors: A. Keil, M. Frese-Schaper, S.K. Steiner, M. Körner, R.A. Schmid, S. Frese
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The treatment of lupus nephritis is still an unmet medical need requiring new therapeutic approaches. Our group found recently that irinotecan, a camptothecin derivate and inhibitor of topoisomerase I (topo I), reversed proteinuria and prolonged survival in mice with advanced lupus nephritis. Irinotecan stabilizes the complex of topo I and DNA and is shown to decrease the binding of lupus-typical anti-dsDNA autoantibodies. The enzyme tyrosyl-DNA-phosphodiesterase 1 (TDP1) functions opposite to irinotecan by releasing topo I from DNA. <h3>Objectives</h3> We tested whether the TDP1 inhibitor furamidine has an additional effect in suppressing murine lupus nephritis when used in combination with the topo I inhibitor irinotecan. Furthermore, we investigated if TDP1 increases the binding of anti-dsDNA antibodies. <h3>Methods</h3> NZB/NZW mice were treated with low-dose irinotecan and furamidine either alone or in combination beginning at 26 weeks of age. DNA relaxation was visualized by gel electrophoresis. Binding of anti-dsDNA antibodies to DNA modified by topo I, TDP1 and the topo I inhibitor camptothecin was determined by ELISA. <h3>Results</h3> Compared to either agent alone, the simultaneous treatment with low-dose irinotecan and furamidine significantly improved survival of NZB/NZW mice. Similar to what has been shown before for irinotecan alone, the combinatorial treatment with low-dose irinotecan and furamidine remained the levels of anti-dsDNA antibodies unchanged. <i>In vitro</i>, recombinant TDP1 increased topo I-mediated DNA relaxation resulting in enhanced binding of anti-dsDNA antibodies. In combination with topo I and camptothecin, TDP1 reversed the inhibitory effects of camptothecin on DNA relaxation and anti-dsDNA binding. <h3>Conclusions</h3> Affecting DNA relaxation by the enzymes topo I and TDP1 and its inhibitors may be a promising approach for the development of new targeted therapies for systemic lupus erythematosus. <h3>Disclosure of Interest</h3> None declared
Neurologic Immune-Related Adverse Events in Oncology Care
Authors: Justin T. Jordan
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Interstitial Fluid Pressure
Authors: BERNARD J. MEYER, ALETTA MEYER, ARTHUR C. GUYTON
Journal: Circulation Research (1968)

Interstitial fluid pressures in the lung were estimated in 39 dogs from pressure measurements made in implanted perforated capsules. Special operative procedures were used to minimize operative trauma of the lungs and infection and inflammation in and around the implanted capsules. In 86% of the preparations, the x-ray findings indicated little remaining inflammation and edema around the capsules, though autopsy findings indicated that a few of these did still have some edema not detectable by x-rays. In 29 of 34 animals in which x-ray findings indicated no edema, the intracapsular pressure was negative. The average of the measurements in all 34 animals was -5.8 mm Hg (± 0.8 SEM ), and in the 29 animals with negative pressure values the average was -7.3 mm Hg (± 0.6 SEM ). In eight capsules the pressures were below -10 mm Hg, ranging to -16 mm Hg. Because the tissues around some of the capsules undoubtedly still had varying degrees of inflammation and edema, despite the failure of roentgenograms to show these, it is suggested that the normal interstitial fluid pressure of pulmonary tissues in dogs is somewhat more negative than the capsule pressure measurements indicate, perhaps as low as -10 mm Hg.
Radionuclide venography in inferior vena cava and iliofemoral vein obstruction.
Authors: N J Peng, P H Lai, G H Jao, D G Tsay, R S Liu
Journal: Clinical Nuclear Medicine (2001)

PENG, NAN-JING M.D.; LAI, PING-HONG M.D.; JAO, GANG-HONG M.D.; TSAY, DAW-GUEY M.D.; LIU, REN-SHYAN M.D. Author Information
The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR
Authors: Liang Zhou, Shuang Chen, Yu Zhang, Maciej Kmieciak, Yun Leng, Lihong Li, Hui Lin, Kathryn A. Rizzo, Catherine I. Dumur, Andrea Ferreira-Gonzalez, Mohamed Rahmani, Lawrence Povirk, Sri Chalasani, Allison J. Berger, Yun Dai, Steven Grant
Journal: Blood (2016)
FRI0610 Ultrasonograpic Assessment Covers a Pitfal of Physycal Examination in the Ankle Joints in Patients with Rheumatoid Arthritis: Table1.
Authors: Y. Toyota, K. Minegishi, M. Hama, R. Yoshimi, Y. Sugiyama, N. Tsuchida, Y. Kunishita, D. Kishimoto, R. Kamiyama, Y. Kirino, M. Takeno, A. Ueda, Y. Ishigatsubo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Though rheumatoid arthritis (RA) commonly affects feet and ankles, precise clinical evaluation for ankle is difficult because of its complex anatomy and deformity as well as other various factors such as obesity and edema. <h3>Objectives</h3> To clarify the utility of ultrasonography (US) examination for evaluating RA ankle by means of comparison to physical examination. <h3>Methods</h3> This study included 56 RA patients (women 82%, age 62±15 y.o., disease duration 7.2±8.2 years, DAS28-ESR 3.95±1.65). Physical examination and patient9s visual analogue scale (VAS) for pain of each bilateral ankle were evaluated. Clinical ankle involvement was defined as ankle joint swelling and/or tenderness on physical examination. Bilateral tibiotalar joints and three tendon sites (anterior tendons; tibialis anterior, extensor hallucis longi, extensor digitorum longi, medial tendons; tibialis posterior, flexor digitorum longi, flexor hallucis longi, lateral tendons; peroneus longi and brevis) were assessed by gray scale (GS) and power Doppler (PD) US examination. Intraarticular synovitis (synovitis) and tenosynovitis were separately assessed by semiquantitative scoring (0-3). Positive US findings were defined as a GS score ≥2 and/or a PD score ≥1. <h3>Results</h3> Among a total of 112 ankle joints, 28 (25.0%) were clinically swollen and 19 (17.0%) had tenderness. US examination showed that synovitis existed in 17 ankles (19.1%) of all the tibiotalar joints, whereas 23 (20.5%) had tenosynovitis of at least one site among three tendon sites. Tenosynovitis lesions of any tendon in a site were detected at 5 (4.5%) of all the anterior sites, 14 (12.5%) of medial sites, and 13 (11.6%) of lateral sites, respectively. When comparing clinical assessments among 4 groups divided according to the existence of synovitis and tenosynovitis (Table), patient9s VAS of ankle is the highest in the group of ankles affected by both synovitis and tenosynovitis. Positive physical findings (swollen and/or tender) were more highly concordant with tenosynovitis (κ =0.64) than synovitis (κ =0.32), and were also more closely associated with tenosynovitis than in synovitis. When positive US findings were set as the gold standard, sensitivity and specificity of positive physical findings (swollen and/or tender) were 0.56 and 0.81 for synovitis, and 0.73 and 0.87 for tenosynovitis, respectively. <h3>Conclusions</h3> This study shows that physical examinations of the ankles often reflect tenosynovitis rather than intraarticular synovitis. US sensitively illustrate RA involvement in the ankle joints, particularly intraarticular lesions, which are often overlooked by physical examination. <h3>Disclosure of Interest</h3> None declared
Worsening of Tourette's disorder due to neuroleptic-induced akathisia
Authors: P Weiden, R Bruun
Journal: American Journal of Psychiatry (1987)

Of 100 patients with Tourette's disorder, six demonstrated unequivocal worsening after their neuroleptic doses were increased. Akathisia was described in the records of all six patients and seemed to be the cause of the deterioration.
PTU-286 Success of prospective assessment for alcoholic liver disease in high risk patients: a well liver clinic model
Authors: MTA Roberts, S McClements, E Donaldson, A Turner, A Al-Rifai
Journal: Gut (2015)

<h3>Introduction</h3> Currently patients at high risk of developing alcoholic liver disease are given advice by health professionals, often only reach hepatology services once advanced cirrhosis or complications are seen. This out-dated system needs improvement to avoid an unprecedented increase in advanced liver disease. We aim to show that our new service of proactive assessment of at risk patients will allow earlier recognition of liver disease in this patient group. <h3>Method</h3> All eligible patients had no history of liver disease and had never seen gastroenterology/hepatology. Patients were referred from Alcohol Specialist Nurses (ASN), Alcohol Assertive Outreach Team (AAOT), Specialist Drug and Alcohol Services (SDAS) or GP after screening using Alcohol Use Disorders Identification Test (AUDIT), with a score ≥16 required. All patients were seen in community clinic by hepatology Advanced Nurse Practioner (ANP), undertaking full clinical assessment and Transient Elastrography (TE) using Fibroscan. Follow up: TE &lt;8 kPa – repeat in 12 months, TE 8–12 kPa – repeat in 6 months, TE 12–20 kPa – repeat in 3 months, TE &gt;20 kPa – refer to hepatology clinic. Any clinical concern regardless of TE score was also referred. All patients were seen between Nov 2013 and Feb 2015. <h3>Results</h3> 527 eligible patients, 387 male and 140 female. Ages ranged from 20–82, mean age 46.1. AUDIT scores range was 16–52, with 79.1% of patients scoring 26–40. 189 patients, 141 male and 48 female, were seen with the remainder failing to attend. 64 (33.8%) reported alcohol abstinence since referral, with a further 7 (3.6%) drinking &lt;21 U/week. 83 patients (43.9%) were high risk, still drinking &gt;50 U/week. TE scores were: &lt;8 kPa in 146 patients, 8–12 kPa in 19, 12–20 kPa in 10, &gt;20 kPa in 7, no result in 7. Those with higher AUDIT scores (26–40) were more likely to have abnormal TE (18.8% &gt;8 kPa) and 42.8% of TE &gt;20 kPa AUDIT was 36–40. 17 patients (8.9%) were referred to hepatology, 7 with TE &gt;20 kPa and 10 on clinical grounds. The remainder had follow up arranged appropriately. <h3>Conclusion</h3> Our new service identified a number of patients who would benefit from specialist hepatology input. Those not requiring specialist input yet may benefit long term from assessment but prospective data on follow up is still in its infancy. As expected, those at higher risk were more likely to have evidence of liver disease. In addition, more than 1/3 of patients involved in this service significantly reduced their alcohol intake. Methods into improving attendance rates needs to be investigated. Overall our service for prospective assessment of those at high risk of alcohol related liver disease is a dynamic new approach that we hope will lead to a greater emphasis on primary prevention. <h3>Disclosure of interest</h3> None Declared.
AB0104 Correlation Between MRI and Conventional Radiography Findings in Knee Osteoarthritis
Authors: N. Bensaoud, S. Rostom, H. Tazi Lachhab, L. Bouhouche, D. Khnaba, R. Bahiri, N. Hajjaj-Hassouni
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Conventional radiography is the simplest and least expensive imaging method for assessing osteoarthritis (OA)of the knee. However, it allows an indirect estimation of cartilage thickness and integrity of the meniscus. Hence the value of modern imaging (ultrasound and MRI) in the diagnosis and the monitoring of this pathology. <h3>Objectives</h3> To assess the correlation between Kellgren &amp; Lawrence (KL) gradings and MRI findings in particular: cartilage defects, bone marrow lesions (BMLS) and meniscal lesions in knee OA patients. <h3>Methods</h3> This is a cross-sectional study including patients with primary knee OA. Demographics, clinical and laboratory characteristics for the disease were collected. Radiographs of the knee were evaluated by Kellgren &amp; Lawrence gradings. All patients underwent magnetic resonance imaging (MRI) of the dominant knee. The results were interpreted according to WORMS system [1] (Whole organ magnetic resonance imaging score) that takes into account 14 regions divised into 04 compartments: medial femoral tibial joint (MFTJ) lateral femoral tibial (LFTJ), femoral patellar (PFJ) and the S region (inter thorny). <h3>Results</h3> Twenty patients with osteoarthritis of the knee were included in the study, 85% were female. The mean age was 59.3±10.3 years. The patients had a mean body mass index 30.1±4.7 kg/ m<sup>2</sup>. The functional discomfort of patients assessed by the WOMAC averaged 38.3±11.3. We found a positive correlation between the Kellgren &amp; Lawrence and MRI data: cartilage defects (r=0.50) and BMLS (r=0,68) and meniscal lesions (r=0.18), statistically significant only for BMLs. Adjusting for age, gender and BMI did not alter these associations. <h3>Conclusions</h3> This study suggests the existence of a correlation between MRI findings and standard radiography in knee OA. Thus, radiography remains useful in daily practice for the diagnosis and assesses the severity of knee osteoarthritis. Further studies are needed to confirm these results. <h3>References</h3> OsteoArthritis and Cartilage (2004) 12, 177–190 <h3>Disclosure of Interest</h3> None declared
Recognition of threats caused by infectious diseases in the Netherlands: the early warning committee
Authors: J C Rahamat-Langendoen, J A van Vliet, A WM Suijkerbuijk
Journal: Eurosurveillance (2006)

The early warning committee was established in order to recognise threats to public health caused by infectious diseases in the Netherlands in a timely and complete fashion. This article describes the outcome of a retrospective and descriptive evaluation into the completeness of the recognitions made by the early warning committee. Information about outbreaks of infectious disease in the Netherlands in 2002 and 2003, as reported in the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine), and about infectious disease events in other countries, was compared with reports of the regular weekly meetings of the Dutch early warning committee. If an outbreak or a foreign event was not mentioned in the meetings of the early warning committee, the cause for this was established. For events in other countries, it was established on the basis of whether or not the event could have been a threat to public health in the Netherlands. All outbreaks of infectious disease in the Netherlands, published or mentioned in the Nederlands Tijdschrift voor Geneeskunde were discussed by the early warning committee. Three of the events occurring in other countries in 2002 had not been discussed by the committee although, based on the criteria for a potential threat to the Netherlands, they should have been: the outbreak of avian influenza A/H5N1 in domestic fowl in Hong Kong, the increase among hospitalised patients of carriers of extended-spectrum â-lactamase producing micro-organisms in Scotland, and outbreaks of measles in several countries. In 2003, all events in other countries that could have posed a threat to the Netherlands were discussed by the early warning committee. In 2002 and 2003, the early warning committee recognised nearly all threats due to infectious diseases and outbreaks of infectious diseases which were of national importance and published in various sources of literature.