tbuckley/cabot-search huggingface dataset:
A6.8 Elevated antibody levels to porphyromonas gingivalis detected in rheumatoid arthritis patients with a specific anti-citrullinated protein/peptide antibody profile
Authors: N Kharlamova, N Sherina, A-M Quirke, K Eriksson, L Israelsson, J Potempa, P Venables, T L Lindberg, K Lundberg
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> <i>Porphyromonas gingivalis</i>, a major cause of chronic periodontitis (PD), has been implicated also in the aetiology of rheumatoid arthritis (RA), specifically in anti-citrullinated protein/peptide antibody (ACPA) positive RA, based on its unique property among pathogens to express a citrullinating peptidylarginine deiminase enzyme. To investigate this hypothesis further, we have analysed the antibody response to <i>P. gingivalis</i> in relation to known risk factors for RA, including autoantibodies, smoking and <i>HLA-DRB1</i> shared epitope (SE) alleles. <h3>Materials and Methods</h3> Serum from 66 patients with chronic PD and 60 individuals without (confirmed by dentists), as well as serum from the EIRA (Epidemiological Investigation of RA) cohort (n = 1985 RA cases and n = 400 controls), were screened by ELISA for presence of antibodies to the <i>P. gingivalis</i>-specific virulence factor arginine gingipainB (RgpB). Antibody levels were analysed in relation to the presence of anti-CCP antibodies, rheumatoid factor, anti-carbamylated protein antibodies and various ACPA fine-specificities, as well as smoking and SE. Differences in antibody levels were examined using Mann-Whitney <i>U</i> test for independent groups. <h3>Results</h3> Significantly higher anti-RgpB antibody levels were detected in the PD subset, compared to the non-PD control subset, and in EIRA RA cases, compared to EIRA controls. Among EIRA RA cases, anti-RgpB IgG levels were significantly increased in RF + as well as anti-CCP + patients. Interestingly, anti-RgpB IgG levels associated with the presence of some ACPA fine-specificities, but not others. There was no association with anti-carbamylated protein antibodies, smoking or <i>HLA-DRB1</i> SE alleles. <h3>Conclusion</h3> Significantly increased anti-RgpB antibody levels in PD serum, compared to non-PD serum, may suggest that elevated anti-RgpB IgG levels can be used as a proxy for chronic PD, in studies where the periodontal status is of interest but unknown. A number of previous studies have demonstrated an association between anti-<i>P. gingivalis</i> antibody responses and ACPA positive RA. However, most of those studies have utilised bacterial lysates as capturing antigen, which are known to contain citrullinated epitopes. By using recombinant RgpB, we circumvent the potential problem of false positive results due to cross-reactive ACPAs, and we conclude that there is an association between elevated anti-RgpB IgG levels and a subset of RA that is characterised by a specific ACPA profile. Interestingly, we could not detect an association with smoking, a well-known risk factor for both PD and ACPA+ RA. These results may point to different aetiologies in different subsets of ACPA positive RA.
LIVER TRANSPLANTATION FOR HIV: ANALYSIS OF OUTCOMES SUGGEST HIV/HCV CO-INFECTED PATIENTS HAVE PROHIBITIVELY POOR SURVIVAL AT 5 YEARS
Authors: Deepak Joshi, Varuna Aluvihare, Ajay Belgaumkar, Suzanne Norris, Michael A. Heneghan, Julia Wendon, Mohammed Rela, Nigel Heaton, John G. O'Grady, Kosh Agarwall
Journal: Hepatology (2008)
Observational Study in Patients with Hymenoptera Allergy: Role of Occupational Exposure, Allergen Immunotherapy, and Indications for Prevention
Authors: Alessandra Toletone, Susanna Voltolini, Donatella Bignardi, Paola Minale, Costantino Troise, Giovanni Passalacqua, Guglielmo Dini, Emanuela Massa, Alessio Signori, Paolo Durando
Journal: Journal of Allergy and Clinical Immunology (2016)
EXTRACCIÓN ENDOSCÓPICA DE CUERPOS EXTRAÑOS INGERIDOS POR ADULTOS
Authors: S Oussama, M Tahiri, F Benali, F Haddad, W Hliwa, A Bellabah, W Badre
Journal: Endoscopy (2014)

Introducción: Ingestión de cuerpos extraños por adultos es una situación infrecuente, puede causar lesiones graves. Es una urgencia terapéutica sobre todo en las dos edades extremas de la vida, a menudo es accidental. Las complicaciones pueden ser inmediatas o retardadas en la remoción o extracción de cuerpos extraños.
Prospective feasibility study on the use of multiband mucosectomy for endoscopic resection of early squamous neoplasia in the esophagus
Authors: Y. Zhang, D. Boerwinkel, S. He, B. Weusten, L. Xue, D. Fleischer, N. Lu, S. Dawsey, S. Zuo, X. Qin, L. Dou, J. Bergman, G. Wang
Journal: Endoscopy (2012)

<b>Background and study aims:</b> Endoscopic resection for esophageal squamous high-grade intraepithelial neoplasia (HGIN) or intramucosal cancer (esophageal squamous cell carcinoma [ESCC]) with the endoscopic resection cap technique is technically difficult, and requires submucosal lifting and multiple snares for piecemeal resections. Multiband mucosectomy (MBM) is an easy-to-use endoscopic resection technique and may be the modality of choice in China, where ESCC is extremely prevalent. The aim of the current study was to prospectively evaluate MBM for piecemeal endoscopic resection of squamous neoplasia of the esophagus. <b>Methods:</b> Patients with HGIN/ESCC and no signs of submucosal invasion or metastatic disease were included in the study. Lesions were delineated using electrocoagulation and resected using the MBM technique. Endpoints were procedure time, endoscopic radicality, complications, histology of the endoscopic resection specimens, and absence of HGIN/ESCC at the endoscopic resection scar during follow-up. <b>Results:</b> A total of 41 patients (26 male; mean age 61 years) underwent MBM; all lesions were visible with white light endoscopy (median length 5 cm, interquartile range [IQR] 4 – 6 cm; median circumferential extent 42 %, IQR 25 – 50 %). Median procedure time was 12 minutes (IQR 8 – 24 minutes). Median number of resections was 5 (IQR 3 – 6). Endoscopic complete resection was achieved in all lesions. There was one perforation, which was treated by application of clips. No other complications were observed. The worst histology was ESCC (n = 19), HGIN (n = 17), middle grade intraepithelial neoplasia (n = 4), and normal squamous epithelium (n = 1). Endoscopic follow-up at 3 months showed HGIN at the endoscopic resection scar in two patients, which was effectively treated endoscopically, and showed normal squamous epithelium in all patients at final follow-up (median 15 months, IQR 12 – 24 months). <b>Conclusion:</b> This first prospective study on MBM for piecemeal endoscopic resection of early esophageal squamous neoplasia showed that MBM was effective for the complete removal of lesions with short procedure time, few complications, effective histological assessment of resected specimens, and durable treatment effect.
Bone Scintigraphy and Radiolabeled White Blood Cell Scintigraphy for the Diagnosis of Mandibular Osteomyelitis
Authors: María Boronat-Ferrater, Marc Simó-Perdigó, Gemma Cuberas-Borrós, Santiago Aguadé-Bruix, Fiorella Dellepiane-Clarke, Elia Torrent-Llongarriu, Montserrat Negre-Busó, Francisco Porta-Biosca, Manel Sáez, Joan Castell-Conesa
Journal: Clinical Nuclear Medicine (2011)

The aim of this study was to evaluate the diagnostic efficacy of bone scintigraphy (BS) and radiolabeled white blood cell scintigraphy (WBCS) in detecting septic activity in the flat bones of the jaw. A retrospective analysis was conducted using 38 studies of combined BS plus WBCS: 33 of them 3-phase BS and 36 of them 2-phase WBCS. These studies were performed on 34 patients, 19 women and 15 men with a mean age of 56 years (22–79), who presented with suspected mandibular osteomyelitis, either acute or chronic exacerbation. The results were compared with histologic findings (55%) or with a minimum clinical/radiologic follow-up of 6 months (average, 21 months), when biopsy results were not available. BS showed a sensitivity of 100%, a specificity of 6.7%, a positive predictive value of 62%, and a negative predictive value of 100%. For WBCS, the corresponding values were as follows: 73.7%, 78.6%, 82%, and 69%. Accuracy was 63.2% for BS and 94.7% for WBCS. WBCS has proven to be a useful test for detecting septic activity in the jaw bone, being more effective than BS alone, which under certain circumstances, can return a very high false-positive rate.
FRI0533 Primary Pyomyositis in Children: A Retrospective Review of 25 Cases
Authors: D. Clemente, I. Martinez, M. de la Torre, F.J. Caballero, J.C. Lopez Robledillo
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Primary pyomyositis is a rare condition in children that should be included in the differential diagnosis of musculoskeletal infections. <h3>Objectives</h3> To describe the clinical features of pyomyositis as well as its diagnostic and therapeutic approach. <h3>Methods</h3> A descriptive and retrospective study was performed by reviewing medical records of patients admitted to our hospital from January 1996 to July 2013 with a diagnosis of primary pyomyositis. <h3>Results</h3> A total of 25 patients (16 men, 9 women) aged between one month and 14 years (median age 2 years) were registered. Two peaks of incidence have been found in the months of July and October. The most frequent clinical manifestations were the presence of local pain (24 patients), fever (18 patients), local swelling (9 patients) and skin rash (7 patients). Predisposing factors in 8 patients (1 strenuous exercise, 4 trauma, 3 intramuscular injections) were found. The primary site was pelvic muscles or lower extremities (20 patients). In laboratory results, we found the presence of leukocytosis, with an average value of 12,936±5.753/uL leukocytes, total neutrophils 4.659/uL ±7.350), ESR of 55±28 mm) and PCR 8±6 mg/dL). CPK was normal in 5 out of 6 patients who were requested. Laboratory results were positive for <i>Staphylococcus aureus</i> (7 patients), <i>Salmonella no tiphy</i> (1 patient) and <i>Bacteroides fragillis</i> (1 patient). Ultrasound suggested the diagnosis in 11 cases and magnetic resonance imaging support the diagnosis in all cases. All patients received intravenous antibiotic therapy (mean duration 11 days) followed by oral antibiotic therapy (mean duration 23 days). 9 patients suffered complications as abscess formation, 3 need abscess aspiration and one of them required surgical drainage. None of our patients had residual functional limitations. <h3>Conclusions</h3> It is important to have a high index of suspicion for pyomyositis in patients with fever and musculoskeletal pain at an early stage in order to initiate start appropriate antibiotic treatment against <i>Staphylococcus aureus</i>. Although ESR and ultrasound may be useful, it is necessary to complement with magnetic resonance imaging in order to support the diagnosis in all cases. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4467
P4-09-22: Multicenter Quality Assurance Profile Review of Lobular Breast Carcinomas Versus the 21 Gene Recurrence Score: Assessment of Clinical Relevance.
Authors: DJ Dabbs, D Hicks, R Tubbs, R Bhargava, A Brufsky
Journal: Cancer Research (2011)

Abstract Introduction The oncotype dx (ODX) 21 gene recurrence score (RS), was intended to predict the 10 year risk of breast cancer recurrence for estrogen receptor positive, lymph node negative disease (NEJM 2004;351:2817–26). The proportions of patients that were reported as low, intermediate and high risk were 51%/22%, 27%. This population of patients was dominated by ductal carcinomas (DCA), with a paucity of classical lobular carcinomas (CLCA), which are ER-rich and low grade histology. To date, there is dearth of data regarding the relationship of the RS and CLCA, and the clinical relevance regarding the ODX RS in CLCA has not been studied. Methods As part of quality assurance review at three institutions, the ODX RS for all CLCA were reviewed in order to determine the perceived clinical relevance of the ODX RS compared to the proportions of RS reported (NEJM 2004;351:2817–26). Results A total of 219 cases of ODX were performed on CLCA. The low/intermediate/high risk profile was 58%/40%/2%. Conclusions (1) The risk profile of ODX for CLCA is very different from the original DCA dominant population previously reported. (2) If the goal of ODX is to identify candidates for chemotherapy, then a high RS is a rare event for CLCA, and as such, the judgment to administer chemotherapy to an individual patient would most likely depend upon factors other than the ODX, because 98 percent of patients are combined low/intermediate risk RS. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-09-22.
The Murine Pulmonary Proteomic Profile Associated with Allergic Aspergillus Fumigatus Exposure
Authors: Ajay P. Nayak, Tara L. Croston, Angela R. Lemons, W.Travis Goldsmith, Michael L. Kashon, Dori M. Germolec, Donald H. Beezhold, Brett J. Green
Journal: Journal of Allergy and Clinical Immunology (2016)
Termination of Early Pregnancy by the 3β-Hydroxysteroid Dehydrogenase Inhibitor Epostane
Authors: Marinus J. Crooij, Coenraad C.A. de Nooyer, B. Ramanath Rao, Gerrit T. Berends, Louis J.G. Gooren, Jannes Janssens
Journal: New England Journal of Medicine (1988)

Progesterone is essential to sustain pregnancy in the first eight weeks. Its synthesis requires the enzyme 3β-hydroxysteroid dehydrogenase (3-HSD). We tested the efficacy of an orally administered 3-HSD inhibitor, epostane, in terminating unwanted early pregnancy. Fifty women in the fifth through eighth weeks of pregnancy took epostane (200 mg orally every six hours) for seven days. By day 14, pregnancy had been terminated in 42 of the 50 patients (84 percent). Eight women (16 percent) did not abort and underwent dilation and curettage. Vaginal blood loss occurred on average on the third day of epostane treatment, and abortion on the fifth day. Two patients had incomplete abortions; one required a transfusion because of blood loss. Nausea was frequent (in 86 percent), but 76 percent of the participants concluded that epostane was preferable to dilation and curettage. The mean (±SD) pretreatment progesterone level (76± 16 nmol per liter) decreased by day 7 (to 16± 11 nmol per liter) and day 14 (to 10±9 nmol per liter) in those who aborted; levels of human chorionic gonadotropin also decreased from the mean at base line (73±72 klU per liter) to 18±7 klU per liter on day 7 and 9±5 klU per liter on day 14. In those who did not abort after epostane treatment, progesterone levels decreased only slightly by day 7 (to 52±21 nmol per liter) and rose again (to 81 ±18 nmol per liter) by day 14. Among women who responded to epostane, normal menstrual periods had resumed by day 42 after the beginning of treatment in 72 percent. We conclude that epostane taken orally is an effective and safe method for the noninvasive termination of undesired early pregnancy. (N Engl J Med 1988; 319:813–7.)
Abstract 1865: <i>ERCC2</i> polymorphisms, smoking, and risk of breast cancer
Authors: Michael S. Conlon, Mary A. Bewick
Journal: Cancer Research (2010)

Abstract The nucleotide excision repair (NER) pathway is important in the repair of bulky DNA lesions, including those that may be induced by cigarette smoking. Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (ERCC2) is an important gene in the NER pathway. Previous research suggests that polymorphisms in this gene may be associated with altered DNA repair capacity, cancer risk and treatment outcome. This study investigated whether two common single nucleotide polymorphisms (SNPs) in ERCC2 (ERCC2 Asp312Gln and ERCC2 Lys751Gln) were associated with risk of breast cancer, or modified a breast cancer risk associated with smoking. We used data previously collected from a primarily Caucasian population in northeastern Ontario Canada of 347 women diagnosed (2002-2004) with breast cancer and 775 population-based controls. The mailed study package contained a questionnaire that provided information on known breast cancer risk factors and lifetime residential and occupational history of exposure to passive and active smoking, and a buccal swab for genetic analyses. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, and used a refined referent group that excluded women with substantial exposure to passive smoke and who were never active smokers. Both SNPs were in Hardy-Weinburg Equilibrium (HWE) in controls. Overall, there was no significant association with either SNP and risk of breast cancer. Women who were active smokers of long duration (&amp;gt; 29 years), or high (&amp;gt;20) pack-years, were at significantly increased risk of breast cancer if they carried the G allele of ERCC2Asp312Gln, with ORs of 1.72 (95% CI 1.10-2.68) and 1.68 (95% CI 1.09-2.61) and p=0.03 and 0.007 for trend, respectively. Similar significantly increased risks were observed in women who carried the A allele of ERCC2 Lys751Gln, with ORs of 1.77 (95% CI 1.14-2.76) and 1.67 (95% CI 1.08-2.58) and p=0.02 and 0.01 for trend, respectively. In conclusion, our data suggest that polymorphisms in the NER pathway may modify a smoking-breast cancer relationship. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1865.
Nitric oxide induces the apoptosis of human BCR-ABL-positive myeloid leukemia cells: evidence for the chelation of intracellular iron
Authors: H Ferry-Dumazet, M Mamani-Matsuda, M Dupouy, F Belloc, D Thiolat, G Marit, M Arock, J Reiffers, MD Mossalayi
Journal: Leukemia (2002)
Pemetrexed plus carboplatin versus pemetrexed in pretreated patients with advanced non-squamous non-small-cell lung cancer: treating the right patients based on individualized treatment effect prediction
Authors: R.C.M. van Kruijsdijk, F.L.J. Visseren, L. Boni, H.J.M. Groen, A.M.C. Dingemans, J.G.J.V. Aerts, Y. van der Graaf, A. Ardizzoni, E.F. Smit
Journal: Annals of Oncology (2016)
Colonoscopy as a Triage Screening Test
Authors: Michael Bretthauer, Mette Kalager
Journal: New England Journal of Medicine (2012)

Colorectal cancer is the third most common cancer worldwide. The lifetime risk of colorectal cancer in the United States is approximately 5%. Clinical symptoms develop late in the course of the disease, and precursor lesions (adenomas) can be easily detected and removed. The disease is a candidate for early detection and prevention by screening. This issue of the Journal features two important studies that shed light on a number of interesting features in screening for colorectal cancer.1,2 Zauber and colleagues present long-term follow-up data on mortality from colorectal cancer from the National Polyp Study.1 After a mean period of . . .
Abstract 3467: Repeated particulate chromate exposure induces chromosome instability and a DNA double strand break repair-deficient phenotype in human lung cells
Authors: Sandra S. Wise, Amie L. Holmes, Hong Xie, Stephen Pelsue, W. Douglas Thompson, John P. Wise
Journal: Cancer Research (2010)

Abstract Particulate hexavalent chromium (Cr(VI)) is a potent respiratory carcinogen with widespread human exposure. The particulate form, for example lead chromate, has been determined to be the most toxic and carcinogenic form. These particles impact at bifurcation sites of the lung and persist in the respiratory tract. Chromosome instability (CIN) is a hallmark of lung cancer with cells exhibiting both translocations and severe aneuploidy. However, the ability of Cr(VI) to induce translocations is unknown. We exposed human lung cells to lead chromate for three sequential 24 h periods, each separated by about a month. After each treatment, cells were seeded at colony forming density, cloned, expanded and retreated. Each generation of clones were tested for their chromium sensitivity, chromosome complement and DNA repair capacity. We found that after the first treatment, lead chromate-treated cells exhibited a normal chromosome complement though a few clones showed an increase in relative survival. After the second exposure, more than half of the clones acquired an abnormal karyotype including numerical and structural alterations. The third treatment resulted in more abnormal clones as well as previously abnormal clones acquiring additional abnormalities. Clones were also treated with soluble Cr(VI) for 24 h followed by a 24 h recovery period to measure DNA double strand break repair. Abnormal clones showed little or no reduction in H2A. X foci formation after 24 h recovery suggesting that these clones had acquired a DNA double strand break repair- deficient phenotype. This work was supported by NIEHS grant ES016893 (J.P.W.). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3467.
Mechanism of Feminization in Primary Liver Cancer
Authors: Michael C. Kew, Marvin A. Kirschner, Guy E. Abrahams, Maurice Katz
Journal: New England Journal of Medicine (1977)

Primary liver cancer occasionally presents with feminization. The mechanism is unknown. We studied a young man with primary liver cancer associated with feminization that disappeared after removal of the tumor. Before operation, the serum estrone level was markedly (1113 pg per milliliter) and estradiol and estriol levels were slightly elevated. Human placental lactogen was also increased (0.52 microng per milliliter). Luteinizing hormone, follicle-stimulating hormone and prolactin levels were normal, and testosterone reduced. Beta subunits of human chorionic gonadotropin were not detected in the serum. In vitro assay of tumor tissue showed estrogenic activity and high levels of these subunits. With a reversed isotope dilution technic with crystallization to constant specific activity, we showed the tumor tissue to convert dehydroepiandrosterone sulfate and dehydroepiandrosterone to estrone and estradiol. Production of beta subunits of chorionic gonadotropin and raised serum levels of placental lactogen provided further evidence that the tumor was functioning as trophoblastic tissue.
Abstract 5047: Dysregulated microRNAs in cervical neoplasm
Authors: Yick Fu Wong, Tak Hong Cheung, Mimi Kwun Nok Man, Mei Yun Yu, So Fan Yim, Nelson S.S. Siu, Keith W.K. Lo, Graeme Doran, Raymond R.Y. Wong, Vivian W. Wang, David I. Smith, Michael J. Worley, Tony K.H. Chung
Journal: Cancer Research (2012)

Abstract MicroRNAs (miRNAs) play an important role in a variety of physiological processes as well as pathophysiological processes, including cancinogenesis. This study was to identify a distinct miRNA expression signature for cervical intraepithelial neoplasia (CIN) and to reveal individual miRNAs that may be involved in the development of cervical carcinoma. Expression profiling using quantitative real-time RT-PCR of 202 miRNAs was performed on micro-dissected high-grade CIN (CIN 2/3) tissues as compared to normal cervical epithelium. The expression of 12 miRNAs including miR-518a, miR-34b, miR-34c, miR-20b, miR-338, miR-9, miR-512-5p, miR-424, miR-345, miR-10a, miR-193b and miR-203 were significantly different between high-grade CIN and normal epithelium. This miRNA signature was further validated by an independent set of high-grade CIN tissue. The same characteristic signature can also be used to distinguish cervical squamous cell carcinoma (SCC) from normal controls. Target prediction analysis revealed that these dysregulated miRNAs control the apoptosis signaling pathway and cell cycle regulation. These findings contribute to understanding of the pathogenesis of cervical carcinoma at the molecular level. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5047. doi:1538-7445.AM2012-5047