tbuckley/cabot-search huggingface dataset:
Ultrasound Targeted Microbubble Destruction-Mediated Delivery of a Transcription Factor Decoy Inhibits STAT3 Signaling and Tumor Growth
Authors: Jonathan A. Kopechek, Andrew R. Carson, Charles F. McTiernan, Xucai Chen, Bima Hasjim, Linda Lavery, Malabika Sen, Jennifer R. Grandis, Flordeliza S. Villanueva
Journal: Theranostics (2015)

Signal transducer and activator of transcription 3 (STAT3) is constitutively activated in many cancers where it acts to promote tumor progression.A STAT3-specific transcription factor decoy has been developed to suppress STAT3 downstream signaling, but a delivery strategy is needed to improve clinical translation.Ultrasound-targeted microbubble destruction (UTMD) has been shown to enhance image-guided local delivery of molecular therapeutics to a target site.The objective of this study was to deliver STAT3 decoy to squamous cell carcinoma (SCC) tumors using UTMD to disrupt STAT3 signaling and inhibit tumor growth.Studies performed demonstrated that UTMD treatment with STAT3 decoy-loaded microbubbles inhibited STAT3 signaling in SCC cells in vitro.Studies performed in vivo demonstrated that UTMD treatment with STAT3 decoy-loaded microbubbles induced significant tumor growth inhibition (31-51% reduced tumor volume vs. controls, p < 0.05) in mice bearing SCC tumors.Furthermore, expression of STAT3 downstream target genes (Bcl-xL and cyclin D1) was significantly reduced (34-39%, p < 0.05) in tumors receiving UTMD treatment with STAT3 decoy-loaded microbubbles compared to controls.In addition, the quantity of radiolabeled STAT3 decoy detected in tumors eight hours after treatment was significantly higher with UTMD treatment compared to controls (70-150%, p < 0.05).This study demonstrates that UTMD can increase delivery of a transcription factor decoy to tumors in vivo and that the decoy can inhibit STAT3 signaling and tumor growth.These results suggest that UTMD treatment holds potential for clinical use to increase the concentration of a transcription factor signaling inhibitor in the tumor.
Testicular tumors, abdominal radiotherapy, and superior mesenteric artery syndrome.
Authors: F E Klee, B R Osswald, S Wysocki
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.8.1626 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8336202 Testicular tumors, abdominal radiotherapy, and superior mesenteric artery syndrome. F E KleexF E KleeSearch for articles by this author , B R OsswaldxB R OsswaldSearch for articles by this author , S WysockixS WysockiSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.8.1626 PDF "Testicular tumors, abdominal radiotherapy, and superior mesenteric artery syndrome.." Journal of Clinical Oncology, 11(8), pp. 1626–1627© 1993 by American Society of Clinical Oncology
Abstract 14594: Gender Differences in Use of Anti-Coagulant For Atrial Fibrillation: A Report From the NCDR®
Authors: Lauren E Thompson, Thomas M Maddox, Steven M Bradley, Lanyu Lei, Gary K Grunwald, Pamela N Peterson, Frederick A Masoudi, Yuichi J Shimada, Alexander Turchin, Yang Song, Gheorghe Doros, Stacie L Daugherty
Journal: Circulation (2015)

Background: Women with atrial fibrillation (AF) have a higher risk of thromboembolism compared to men. In contemporary practice, whether rates of anticoagulation use according to thromboembolic risk vary by gender and if this relationship has changed over time with introduction of expanded treatment options (novel oral anticoagulants [NOACs]) are unknown. Methods: Using the outpatient National Cardiovascular Data Registry (NCDR) PINNACLE registry from 2010-2014, oral anticoagulation (OAC- warfarin or novel anticoagulant) use was compared in women and men with non-valvular AF and CHA2DS2-VASc scores ≥ 2. Patients with documented contraindications to anticoagulation were excluded. Multivariable logistic regression models assessed the association between gender and OAC use (at each CHA2DS2-VASc level) adjusted for demographic and clinical factors, and accounting for clustering by practice using generalized estimating equations. Temporal trends in OAC use were also compared. Results: Of the 658,341 patients with non-valvular AF and CHADS2VASc ≥2, 45.2% were women. The average CHADS2VASc score for women and men was similar (mean±SD, 3.4±1.16 vs 3.4 ±1.19, respectively, p = 0.245). At all thromboembolic risk levels women were less likely than men to have any anticoagulant prescribed (e.g. at CHA2DS2-VASc score = 4 53.4% of women vs. 56.1% of men received OAC), in adjusted analysis, RR 0.95, 95% CI 0.94-0.96, p &lt;0.001(FIGURE). In temporal analysis, use of OAC increased over time in women and men (p &lt; 0.001 for trend) with increased NOAC use in both genders (p &lt;0.001 for trend). Conclusions: In this contemporary, ambulatory cohort of patients with non-valvular AF, women were slightly less likely to receive OAC across the spectrum of thromboembolic risk. Further studies are needed to understand the causes of these differences such as under-appreciation of gender as a risk factor or unequal treatment based on gender alone.
Antithoracic duct lymphocyte globulin therapy of severe aplastic anemia
Authors: B Camitta, RJ O'Reilly, L Sensenbrenner, J Rappeport, R Champlin, K Doney, C August, RG Hoffmann, D Kirkpatrick, R Stuart, G Santos, R Parkman, RP Gale, R Storb, D Nathan
Journal: Blood (1983)
Polysaccharide Synthesis in Frozen Tissue Sections as a Histochemical Method for Phosphorylase&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Benjamin Goldberg, O. Ruth Wade, Howard W. Jones, Jr.
Journal: JNCI Journal of the National Cancer Institute (1952)

Polysaccharide Synthesis in Frozen Tissue Sections as a Histochemical Method for Phosphorylase Get access Benjamin Goldberg, Benjamin Goldberg Department of Gynecology, School of Medicine, The Johns Hopkins University, Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar O. Ruth Wade, O. Ruth Wade Department of Gynecology, School of Medicine, The Johns Hopkins University, Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard W. Jones, Jr. Howard W. Jones, Jr. Department of Gynecology, School of Medicine, The Johns Hopkins University, Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 2, October 1952, Pages 543–557, https://doi.org/10.1093/jnci/13.2.543 Published: 01 October 1952 Article history Received: 26 June 1952 Published: 01 October 1952
Diversity of Envelope Antigens on Murine Type-C RNA Viruses2
Authors: Tadao Aoki, Robert J. Huebner, Kenneth S. S. Chang, Macie M. Sturm, Margaret Liu
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Diversity of Envelope Antigens on Murine Type-C RNA Viruses Get access Tadao Aoki, Tadao Aoki Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Huebner, Robert J. Huebner Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenneth S. S. Chang, Kenneth S. S. Chang Search for other works by this author on: Oxford Academic PubMed Google Scholar Macie M. Sturm, Macie M. Sturm Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret Liu Margaret Liu Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1189–1197, https://doi.org/10.1093/jnci/52.4.1189 Published: 01 April 1974 Article history Received: 29 August 1973 Accepted: 14 November 1973 Published: 01 April 1974
The summit-annotated contract technique for hospitalized adolescents
Authors: H A Rosenstock
Journal: American Journal of Psychiatry (1975)

The author describes a technique for use with adolescents (perferably nonpsychotic, acting-out patients) in the terminal phase of psychiatric hospitalization. Patient, parents, and therapist have a summit meeting during which they write a contract which is a prerequisite of the patient's discharge. The document, which all parties sign, specifies conditions of the patient's return to family life. A case report, including a contract, illustrates the use of the technique.
PWE-104 Gamma-glutamyl transferase but not markers of hepatic fibrosis is associated with cardiovascular disease in older people with type 2 diabetes mellitus: the edinburgh type 2 diabetes study
Authors: J Morling, J Fallowfield, R Williamson, C Robertson, S Glancey, I Guha, M Strachan, J Price
Journal: Gut (2015)

<h3>Introduction</h3> Patients with chronic liver disease (CLD) and, in particular, non-alcoholic fatty liver disease (NAFLD) are known to have both higher all-cause mortality and cardiovascular (CV) mortality rates than the general population. Beyond investigation of GGT there has been little exploration of the relationship between CV disease (CVD) and other markers of liver disease (non-specific liver injury, steatosis, steatohepatitis, liver fibrosis or portal hypertension). We examined the association of prevalent and incident CV disease with CLD in a cohort of community-based people with type 2 diabetes (T2DM) in order to determine the relationship between these two important conditions. <h3>Method</h3> 1066 participants of the Edinburgh Type 2 Diabetes Study, a large, randomly-selected population of patients with T2DM aged 60–75 years were invited for liver assessment. A range of liver disease markers (non-specific liver injury – serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT); steatosis – liver ultrasound; steatohepatitis – serum cytokeratin-18; fibrosis – serum AST to Platelet Ratio Index (APRI), AST:ALT ratio, Enhanced Liver Fibrosis (ELF) panel, Fibrosis-4 Score, NAFLD Fibrosis Score; portal hypertension – platelet count) were measured. Subjects were followed-up using patient and GP questionnaires and record linkage for incident CV events (coronary artery disease (CAD), cerebrovascular disease and peripheral vascular disease). <h3>Results</h3> At baseline there were 372/1035 patients with prevalent CVD, including 319/1035 with CAD. After mean follow-up of 4.4 years there were 121/1035 incident CVD events, including 76/121 CAD events. There were 30/82 CVD related deaths. However, risk of dying from or developing CVD was no higher in subjects with steatosis than without (HR 1.31 95% CI 0.78–2.20, p &gt; 0.05). The only significant relationship was with GGT (U/L log<sub>2</sub>incident CVD, adjusted HR 1.18 95% CI 1.00–1.39, p = 0.045; incident CAD, adjusted HR 1.24 95% CI 1.02–2.51, p = 0.032). <h3>Conclusion</h3> We conducted the first comprehensive population-based study of older people with T2DM and found no association between non-invasive markers of hepatic steatosis, steatohepatitis, or fibrosis with the development of, or mortality from, CVD. Our finding of a significant independent association between GGT and CVD warrants further evaluation as a potentially useful addition to current CV risk prediction models in T2DM. <h3>Disclosure of interest</h3> None Declared.
Stroke Imaging
Authors: Ryszard M. Pluta, Cassio Lynm, Robert M. Golub
Journal: JAMA (2011)

Occluded (blocked) blood vesselA stroke is a sudden event that leads to change or loss of brain function.When a stroke is caused by decreased blood flow to the brain, it is an ischemic stroke.When the cause is bleeding into the brain, it is a hemorrhagic stroke.When the bleeding is on the surface of the brain, it is a subarachnoid hemorrhage.The September 21, 2011, issue of JAMA includes an article on depression and stroke.
SAT0233 Acute Anterior Uveitis in Ankylosing Spondylitis: Association with Inflammatory Bowel Disease and Psoriasis Independent of HLA-B27
Authors: A. Omar, T. Boyd, I. Sari, A. Thavaneswaran, R. Ayearst, R. Inman, N. Haroon
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Acute anterior uveitis (AAU) is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS), developing in 20-30% of these patients during the course of their disease. <h3>Objectives</h3> Our aim was to study the characteristics and risk factors associated with AAU in our cohort of AS patients. <h3>Methods</h3> From our longitudinal observational cohort, 716 patients with AS (meeting modified New York Criteria) and at least 2 years follow up were included and who were followed from January 2006 to November 2013. Patients with (AAU+) and without (AAU-) uveitis were compared. Uveitis flare rates were calculated per year. T-test, Chi-squared tests and logistic regression were used where appropriate. <h3>Results</h3> Of the 716 patients, 225 (31.4%) had a reported diagnosis of AAU at their baseline clinic visit. Patients with AAU+ were older compared to the AAU- group (mean age of 42.6 vs 37.9 years; p&lt;0.001). AAU started after the onset of back pain in the majority of patients with only 10.5% of patients reporting onset of AAU before onset of AS related back pain. Patients with AAU had higher HLA-B27 (B27) prevalence (91.8% vs 82.1%, p&lt;0.05). In the multivariate analysis (MVA), AAU was independently associated with age, B27, psoriasis, IBD and elevated CRP. B27 (OR=2.66 [95% CI=1.44-4.9]), psoriasis (OR=2.36 [95% CI=1.41-3.97]) and IBD (OR=2.25 [95% CI=1.27-4]) are the strongest independent predictors of AAU. Within the AS/IBD group (n=86), 43% of these patients had a history of AAU, of which 81% were B27 positive. In patients with AAU, there was a trend towards more peripheral arthritis and enthesitis. The BASMI score was higher in patients with AAU (3.3 vs 2.7, P&lt;0.05), however there was no association found on MVA. There was no significant difference found between the two groups in terms of BASDAI score, hypertension, diabetes, previous history of myocardial infarctions and smoking history. There was no difference found between NSAID use at baseline (66.1% vs. 66.5%, p=0.90). Patients with AAU were more frequently treated with DMARDs (26% vs. 16.5%, p&lt;0.01). Sulfasalazine was used more frequently in the AAU+ group (14.2% vs. 7.9%, p&lt;0.01). Use of biologics was similar at baseline (22.2% vs. 18.4%, p=0.23). <h3>Conclusions</h3> In our cohort of AS patients, an increased frequency of HLA-B27 was seen in AAU+ AS. AAU+ AS is associated with psoriasis and IBD. The psoriasis and IBD association is independent of HLA-B27, suggesting an interaction of other genetic as well as environmental factors. At baseline DMARD use was associated with AAU, likely reflecting the association with peripheral joint disease. <h3>Disclosure of Interest</h3> None declared
EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation
Authors: Eskil Eskilsson, Gro V. Rosland, Krishna M. Talasila, Stian Knappskog, Olivier Keunen, Andrea Sottoriva, Sarah Foerster, Gergely Solecki, Torfinn Taxt, Radovan Jirik, Sabrina Fritah, Patrick N. Harter, Kristjan Välk, Jubayer Al Hossain, Justin V. Joseph, Roza Jahedi, Halala S. Saed, Sara G. Piccirillo, Inma Spiteri, Lina Leiss, Philipp Euskirchen, Grazia Graziani, Thomas Daubon, Morten Lund-Johansen, Per Øyvind Enger, Frank Winkler, Christoph A. Ritter, Simone P. Niclou, Colin Watts, Rolf Bjerkvig, Hrvoje Miletic
Journal: Neuro-Oncology (2016)

Amplification of the epidermal growth factor receptor (EGFR) and its mutant EGFRvIII are among the most common genetic alterations in glioblastoma (GBM), the most frequent and most aggressive primary brain tumor.In the present work, we analyzed the clonal evolution of these major EGFR aberrations in a small cohort of GBM patients using a unique surgical multisampling technique. Furthermore, we overexpressed both receptors separately and together in 2 patient-derived GBM stem cell lines (GSCs) to analyze their functions in vivo in orthotopic xenograft models.In human GBM biopsies, we identified EGFR amplification as an early event because EGFRvIII mutations emerge from intratumoral heterogeneity later in tumor development. To investigate the biological relevance of this distinct developmental pattern, we established experimental model systems. In these models, EGFR+ tumor cells showed activation of classical downstream signaling pathways upon EGF stimulation and displayed enhanced invasive growth without evidence of angiogenesis in vivo. In contrast, EGFRvIII+ tumors were driven by activation of the prototypical Src family kinase c-Src that promoted VEGF secretion leading to angiogenic tumor growth.The presented work shows that sequential EGFR amplification and EGFRvIII mutations might represent concerted evolutionary events that drive the aggressive nature of GBM by promoting invasion and angiogenesis via distinct signaling pathways. In particular, c-SRC may be an attractive therapeutic target for tumors harboring EGFRvIII as we identified this protein specifically mediating angiogenic tumor growth downstream of EGFRvIII.
A novel approach in benign biliary stricture – balloon dilation combined with cholangioscopy-guided steroid injection
Authors: Tomazo Franzini, Renata Moura, Gustavo Rodela, Wellington Andraus, Paulo Herman, Luiz D’Albuquerque, Eduardo de Moura
Journal: Endoscopy (2015)

The first-line endoscopic strategy for the treatment of benign biliary stricture (BBS) consists of balloon dilation combined with the placement of multiple plastic stents, which has a success rate of more than 80 %. Nevertheless, stricture may recur in 10 % to 30 % of cases after initial resolution [1] [2]. Cholangioscopy is a useful adjunct to endoscopic retrograde cholangiopancreatography (ERCP) for the evaluation and treatment of refractory BBS [3] [4].
Cancer therapy with interleukin-2: immunologic manipulations can mediate the regression of cancer in humans.
Authors: S A Rosenberg
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.3.403 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3258361 Cancer therapy with interleukin-2: immunologic manipulations can mediate the regression of cancer in humans. S A RosenbergxS A RosenbergSearch for articles by this author Show More National Cancer Institute, Bethesda, MD. https://doi.org/10.1200/JCO.1988.6.3.403 First Page PDF © 1988 by American Society of Clinical Oncology
The Code
Authors: Bruce H Campbell
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of the Virus of Lymphocytic Choriomeningitis on the Course of Leukemia in Guinea Pigs and Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Eli M. Nadel, Victor H. Haas
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Effect of the Virus of Lymphocytic Choriomeningitis on the Course of Leukemia in Guinea Pigs and Mice Get access Eli M. Nadel, Eli M. Nadel National Cancer Institute and National Institute of Allergy and Infectious Diseases,4Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Victor H. Haas Victor H. Haas National Cancer Institute and National Institute of Allergy and Infectious Diseases,4Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 2, August 1956, Pages 221–231, https://doi.org/10.1093/jnci/17.2.221 Published: 01 August 1956 Article history Received: 21 May 1956 Published: 01 August 1956
DSM-III-R axis II comorbidity in dysthymia and major depression
Authors: C M Pepper, D N Klein, R L Anderson, L P Riso, P C Ouimette, H Lizardi
Journal: American Journal of Psychiatry (1995)

Dysthymia is generally believed to be associated with a high rate of DSM-III-R axis II comorbidity. However, it is unclear whether this rate is higher than that for other axis I disorders, how many dysthymic patients have personality disorders, and what the most common co-occurring axis II conditions are.Ninety-seven outpatients with early-on-set dysthymia and 45 with episodic major depression were administered structured diagnostic interviews for axis I and II disorders. In addition, knowledgeable informants were independently interviewed about axis II conditions in the patients.A significantly greater proportion of dysthymic patients (60%) than patients with episodic major depression (18%) met criteria for a personality disorder. The most common axis II conditions among dysthymic patients were borderline, histrionic, and avoidant personality disorder. Informants' reports yielded similar results.These data indicate that early-onset dysthymia is associated with significantly greater axis II comorbidity than episodic major depression. Further work is necessary to elucidate the processes underlying this association.
Bariatric Surgery or Medical Therapy for Obesity
Authors: Fernando Fornari, Virgínia R Comis, Hugo R K Lisboa
Journal: New England Journal of Medicine (2012)

report the results of rigorous randomized, controlled trials comparing various types of bariatric surgery with medical therapy for obesity-associated type 2 diabetes.However, we would like to raise the important issue of micronutrient assessment and management in patients undergoing bariatric surgery.The risk of deficiency (of thiamine; vitamins B 6 , B 12 , and D; calcium; iron; or copper, zinc, or both) is increasingly recognized after malabsorptive bariatric surgery, but these deficiencies may be inadequately diagnosed. 3 For example, we recently described the incidence and prevalence of copper deficiency after Roux-en-Y gastric bypass surgery as 18.8% and 9.6%, respectively. 4 Consensus guidelines recommend that patients should be comprehensively monitored for micronutrient deficiencies after bariatric surgery. 5Unfortunately, the articles by Mingrone et al. and Schauer et al. do not describe such monitoring.Given the high prevalence of preoperative and postoperative deficiencies of specific nutrients, 3 it is important for clinicians to be aware of these potential complications and to appropriately monitor and treat patients for deficiencies of vitamins, minerals, and trace elements after these increasingly common surgical procedures for obesity.
60PD Predictive role of stromal tumor infiltrating lymphocytes (TILs) in patients with metastatic HER2-positive breast cancer (BC) treated with trastuzumab
Authors: C. Yoo, J.-A. Yoon, H.J. Lee, J.-H. Ahn, K.H. Jung, G. Gong, S.B. Kim
Journal: Annals of Oncology (2015)