tbuckley/cabot-search huggingface dataset:
Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate
Authors: S.A. Koppes, S. Ljubojevic Hadzavdic, I. Jakasa, N. Franceschi, R. Jurakić Tončić, B. Marinović, R. Brans, S. Gibbs, M.H.W. Frings-Dresen, T. Rustemeyer, S. Kezic
Journal: British Journal of Dermatology (2016)

Recent studies have demonstrated allergen-specific differences in the gene expression of inflammatory mediators in patch tested skin.To determine levels of various inflammatory mediators in the stratum corneum (SC) after patch testing with common contact allergens and the skin irritant sodium lauryl sulfate (SLS).In total, 27 individuals who had previously patch tested positive to nickel, chromium, methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) or para-phenylenediamine were retested and then patch tested with SLS and petrolatum, with petrolatum serving as the patch test control. At 72 h, the test sites were clinically graded and the SC samples collected on adhesive tape.The levels of 18 of the 32 quantified mediators differed significantly from that of the control patches for at least one of the tested substances. SLS and MCI/MI induced the largest number of immunomediators. Interleukin (IL)-16 levels were significantly higher in patch test reactions in all allergens than they were in the controls, while no significant difference was detected for SLS. Furthermore, a strong negative correlation was found between strength of patch test reaction and IL-1α levels.Cytokine profiles in the SC of patch tested skin did not show a distinct allergen-specific pattern. However, MCI/MI induced a larger and wider immune response than the other allergens, perhaps due to its potency as an irritant. The levels of IL-16 were significantly increased in patch test reactions to allergens but not to SLS; thus, they may help clinicians to differentiate between allergic contact dermatitis and irritant contact dermatitis.
Case 23-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Raymond S. Koff, James J. Galdabini
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 17-year-old girl was admitted to the hospital because of fever.She was well until two weeks previously, when an upper-respiratory-tract infection developed, with a progressive sore throat. Nine days before entry a physician found that she was febrile; the tonsils were enlarged, with a white exudate, and tender cervical lymph nodes were palpated. Penicillin was begun. The fever diminished, but the patient did not improve. During the next few days the temperature ranged as high as 38.3°C, and diffuse myalgias appeared. Four days before admission aspirin was added. On the following day she appeared worse, and . . .
The Bruton's Tyrosine Kinase (BTK) Inhibitor Ibrutinib (PCI-32765) Promotes High Response Rate, Durable Remissions, and Is Tolerable in Treatment Naïve (TN) and Relapsed or Refractory (RR) Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Patients Including Patients with High-Risk (HR) Disease: New and Updated Results of 116 Patients in a Phase Ib/II Study
Authors: John C. Byrd, Richard R. Furman, Steven Coutre, Ian W. Flinn, Jan A. Burger, Kristie A. Blum, Jeff Sharman, Barbara Grant, Jeffrey A. Jones, William G. Wierda, Weiqiang Zhao, Nyla A. Heerema, Amy J. Johnson, Anh Tran, Fong Clow, Lori Kunkel, Danelle F. James, Susan O'Brien
Journal: Blood (2012)
Expanding pulmonary rehabilitation capacity. One size won't fit all
Authors: Mike Morgan
Journal: Thorax (2016)

Pulmonary rehabilitation for people with chronic lung disease is a formal programme of care that includes supervised exercise and self-management training. The results of numerous clinical trials show that it can improve exercise capacity, dyspnoea and health status. These benefits have a larger effect size than can be obtained with any other medical therapy for COPD. The benefits last for approximately 12 months and can be regained with repeat programmes. Effective as it has been in a research setting, the challenge for the pulmonary rehabilitation community is to demonstrate that these positive findings can be reproduced in real life and that there is sufficient capacity in the health system to accommodate all those people that could benefit.

Earlier this year the Royal College of Physicians of London (RCP) produced the second of two publications from the largest audit of pulmonary rehabilitation in England and Wales that has ever been conducted.1 ,2 This audit included 7413 patients from 224 programmes in a wide variety of settings and described both the provision and the outcomes of rehabilitation. Even though the headline numbers appear impressive, the authors estimate that given 1.2 million people have COPD in the UK, only about 15% of patients with significant disability are ever referred for rehabilitation. The reasons for this are not clear but could relate to perceived lack of efficacy by referrers or lack of local capacity. The former is difficult to accept because the benefits of rehabilitation are clearly stated in all evidence-based clinical guidelines for COPD but referral may not yet be second nature to all primary or secondary care clinicians. Insufficient capacity, however, is certainly an important issue. In the RCP audit the median capacity of programmes was between 200 and 300 patients per year which is unlikely to satisfy the country's needs. …
The unique role of the agent within the romantic group
Authors: Aaron Ben-Ze'ev, Angelika Krebs
Journal: Behavioral and Brain Sciences (2016)

In this commentary, we apply the authors' view to small groups consisting of two people who are in a committed romantic relationship. Our focus is on the circumstances that make it more likely that people will stay within such a group and minimize the chances that they will replace their partner. In our restless society, such ongoing replacement is a pressing issue.
Influence of Allele Level HLA Typing on Unrelated Donor (UD) Transplantation for High Risk Myeloid Leukemias.
Authors: S. Parmar, M. Fernandez-Vina, P. Liu, P. Cano, B. S. Andersson, M. Munsell, S. Giralt, J. McMannis, E. J. Shpall, D. Couriel, S. Ghosh, R. Champlin, M. de Lima
Journal: Blood (2005)
Azacitidine in Acute Myeloid Leukemia with &gt;30% Bone Marrow Blasts and &lt;15 G/L White Blood Cell Count: Results from the Austrian Azacitidine Registry of the AGMT Study Group Versus Randomized Controlled Phase III Clinical Trial Data
Authors: Lisa Pleyer, Sonja Burgstaller, Reinhard Stauder, Michael Girschikofsky, Heinz Sill, Konstantin Schlick, Josef Thaler, Britta Halter, Sigrid Machherndl-Spandl, Armin Zebisch, Angelika Pichler, Michael Pfeilstöcker, Eva-Maria Autzinger, Alois Lang, Klaus Geissler, Daniela Voskova, Dietmar Geissler, Wolfgang R Sperr, Sabine Hojas, Inga Mandac Rogulj, Johannes Andel, Richard Greil
Journal: Blood (2015)
Identification Of Specific Hematopoietic Populations Present In Peripheral Blood Mononuclear Cells That Increase Erythroid Output Directly Or Through Feeder/Stromal Cell-Like Properties
Authors: Esther Heideveld, Valentina Tirelli, Francesca Masiello, Fatemehsadat Esteghamat, Nurcan Yagci, Marieke von Lindern, Anna Rita F Migliaccio, Emile van den Akker
Journal: Blood (2013)
Natural History, Genetic Aberrations and Survival Distinguish Primary Plasma Cell Leukemia from Multiple Myeloma with Leukemic Transformation.
Authors: Rodger E. Tiedemann, Natalia Gonzalez-Paz, Rafael Santana-Davila, Wee Joo Chng, Rhett Ketterling, Morie A. Gertz, Tammy Price-Troska, Kimberly Henderson, Philip R. Greipp, S. Vincent Rajkumar, Robert Kyle, Angela Dispenzieri, Martha Lacy, Rafael Fonseca
Journal: Blood (2006)
Patient Characteristics Associated with Successful Mobilization of Peripheral Blood Stem and Progenitor Cells Following Cytotoxic Chemotherapy and Peg-G-CSF Stimulation.
Authors: Ingmar Bruns, Johannes C. Fischer, Akos G. Czibere, Cangül Kilic, Roland Fenk, Fabian Zohren, Ralf Kronenwett, Rainer Haas, Ralf Kronenwett
Journal: Blood (2007)
Truncating titin mutations are associated with a mild and treatable form of dilated cardiomyopathy
Authors: Joeri A. Jansweijer, Karin Nieuwhof, Francesco Russo, Edgar T. Hoorntje, Jan D.H. Jongbloed, Ronald H. Lekanne Deprez, Alex V. Postma, Marieke Bronk, Ingrid A.W. van Rijsingen, Simone de Haij, Elena Biagini, Paul L. van Haelst, Jan van Wijngaarden, Maarten P. van den Berg, Arthur A.M. Wilde, Marcel M.A.M. Mannens, Rudolf A. de Boer, Karin Y. van Spaendonck‐Zwarts, J. Peter van Tintelen, Yigal M. Pinto
Journal: European Journal of Heart Failure (2016)
Efficacy of High-Dose Therapy and Autologous Stem Cell Transplantation for Chemoresistant Hodgkin’s Lymphoma.
Authors: Tracee L. Metcalfe, Ted A. Gooley, Oliver W. Press, John M. Pagel, Stephen H. Petersdorf, William Bensinger, Leona Holmberg, David G. Maloney, Ajay K. Gopal
Journal: Blood (2005)
Unusual Abdominal and Pelvic Tumors
Authors: István Láng, Erika Hitre, Zsolt Horváth, Mária Gődény
Journal: Journal of Clinical Oncology (2003)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2003.03.176 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12972533 Unusual Abdominal and Pelvic Tumors CASE 3. RESECTION OF ORIGINALLY INOPERABLE LIVER METASTASES OF GASTROINTESTINAL STROMAL TUMOR AFTER IMATINIB MESYLATE THERAPY István LángxIstván LángSearch for articles by this author , Erika HitrexErika HitreSearch for articles by this author , Zsolt HorváthxZsolt HorváthSearch for articles by this author , Mária GődényxMária GődénySearch for articles by this author Show More Departments of Medical Oncology and Diagnostic Radiology, National Institute of Oncology, Budapest, Hungary https://doi.org/10.1200/JCO.2003.03.176 First Page Full Text PDF Figures and Tables © 2003 by American Society of Clinical Oncology
Use of FDG Positron Emission Tomography (FDG-PET) in Patients with Hodgkin Lymphoma (HL): a Population Based Study.
Authors: Stefano Luminari, Marina Cesaretti, Stefano Madrigali, Bruno Bagni, Francesco Merli, Lucia Mangone, Annibale Versari, Francesca Re, Vincenzo De Lisi, Livia Ruffini, Stefano Ferretti, Antonio Cuneo, Massimo Federico
Journal: Blood (2009)
Impact of Time-of-Flight Reconstruction on Cardiac PET Images of Obese Patients
Authors: Frank P. DiFilippo, Richard C. Brunken
Journal: Clinical Nuclear Medicine (2016)

Purpose The benefit of time-of-flight (TOF) information in PET oncology studies is well established, demonstrating improved signal-to-noise ratio and enhanced lesion detection. In cardiac PET studies, tracer distribution and study interpretation differ substantially from oncology PET, and the benefit of TOF is less established. We investigate the impact of TOF on reconstructed myocardial distribution in 82Rb PET perfusion studies of obese patients, for whom TOF would have most significant impact. Methods Cardiac 82Rb PET data of 13 obese patients (8 male, 5 female patients; weight, mean, 139 kg [range, 109–191 kg]; body mass index, mean, 49 kg/m2 [range, 36–76 kg/m2]) were analyzed retrospectively. Images were reconstructed with and without TOF and with varying number of iterative updates (2–12 iterations). Convergence and clinical relevance of differences were assessed both visually and quantitatively (automated 17-segment scoring). An anthropomorphic torso phantom also was scanned in order to study how TOF affects reconstruction of a myocardial distribution. Results Time-of-flight imaging provided significant improvement in image quality and convergence rate compared with non-TOF imaging. Time-of-flight reconstruction typically required 2 to 4 iterations to converge versus 8 to 12 iterations for non-TOF reconstruction. Even at 12 iterations, non-TOF images occasionally had apparent differences in relative perfusion compared with TOF images that exceeded 10% and were considered likely to affect clinical interpretation. Conclusions Time-of-flight reconstruction has a significant clinical impact on cardiac PET in obese patients. When interpreting cardiac studies from non–TOF-capable PET scanners, one must ensure to reconstruct images with sufficient iterations and to be aware of potential artifacts.
Mediterranean Diet Score and Its Association with Age-Related Macular Degeneration
Authors: Ruth E. Hogg, Jayne V. Woodside, Alanna McGrath, Ian S. Young, Jesus L. Vioque, Usha Chakravarthy, Paulus T. de Jong, Mati Rahu, Johan Seland, Gisele Soubrane, Laura Tomazzoli, Fotis Topouzis, Astrid E. Fletcher
Journal: Ophthalmology (2016)
MicroRNA-424 impairs ubiquitination to activate STAT3 and promote prostate tumor progression
Authors: Cecilia Dallavalle, Domenico Albino, Gianluca Civenni, Jessica Merulla, Paola Ostano, Maurizia Mello-Grand, Simona Rossi, Marco Losa, Gioacchino D’Ambrosio, Fausto Sessa, George N. Thalmann, Ramon Garcia-Escudero, Andrea Zitella, Giovanna Chiorino, Carlo V. Catapano, Giuseppina M. Carbone
Journal: Journal of Clinical Investigation (2016)

Mutations and deletions in components of ubiquitin ligase complexes that lead to alterations in protein turnover are important mechanisms in driving tumorigenesis. Here we describe an alternative mechanism involving upregulation of the microRNA miR-424 that leads to impaired ubiquitination and degradation of oncogenic transcription factors in prostate cancers. We found that miR-424 targets the E3 ubiquitin ligase COP1 and identified STAT3 as a key substrate of COP1 in promoting tumorigenic and cancer stem-like properties in prostate epithelial cells. Altered protein turnover due to impaired COP1 function led to accumulation and enhanced basal and cytokine-induced activity of STAT3. We further determined that loss of the ETS factor ESE3/EHF is the initial event that triggers the deregulation of the miR-424/COP1/STAT3 axis. COP1 silencing and STAT3 activation were effectively reverted by blocking of miR-424, suggesting a possible strategy to attack this key node of tumorigenesis in ESE3/EHF-deficient tumors. These results establish miR-424 as an oncogenic effector linked to noncanonical activation of STAT3 and as a potential therapeutic target.
Histologist's original opinion compared with multidisciplinary team in determining diagnosis in interstitial lung disease
Authors: PS Burge, J Reynolds, S Trotter, GA Burge, G Walters
Journal: Thorax (2016)

Guidelines recommend that multidisciplinary interstitial lung disease meeting (ILD MDT) decisions become the gold standard for diagnosis, replacing the histologist from this position, and identify this as requiring supportive evidence. We have compared diagnoses from lung biopsy material made by expert histologists with the subsequent consensus opinion from a properly constituted ILD MDT in 71 consecutive patients referred to a regional thoracic unit. MDT changed the original histological diagnoses in 30% (95% CI 19.3% to 41.6%) and strengthened the diagnoses from probable to confident in a further 17% (95% CI 9.1% to 27.7%). The assessment of hypersensitivity pneumonitis, non-necrotising granulomas and organising pneumonia accounted for the majority of the changes.
Therapeutic interventions for improving self-reported function in patients with chronic ankle instability: a systematic review
Authors: Kyle B Kosik, Ryan S McCann, Masafumi Terada, Phillip A Gribble
Journal: British Journal of Sports Medicine (2016)

Objective To identify which therapeutic intervention may be most effective for improving self-reported function in patients with chronic ankle instability (CAI). Design Systematic literature review. Articles were appraised using the Downs and Black Checklist by 3 reviewers. Data sources PubMed along with CINAHL, MEDLINE and SPORTDiscus within EBSCOhost for pertinent articles from their inception through August 2016. Eligibility criteria for selected studies Articles included were required to (1) be written in English, (2) report adequate data to calculate effect sizes, (3) identify patients with CAI, (4) use some form of therapeutic intervention and (5) use a self-reported questionnaire as a main outcome measurement. Results A broad spectrum of therapeutic interventions were identified related to balance training, multimodal rehabilitation, joint mobilisation, resistive training, soft-tissue mobilisation, passive calf stretching and orthotics. All of the articles included in the balance training category had moderate-to-strong Hedges g with none of the 95% CIs crossing 0. Hedges g effect sizes ranged from −0.67 to −2.31 and −0.51 to −1.43 for activities of daily living and physical activity, respectively. The multimodal rehabilitation category also produced moderate-to-strong Hedges g effect sizes but with large CIs crossing 0. Hedges g effect sizes ranged from −0.47 to −9.29 and −0.62 to −24.29 for activities of daily living and physical activity, respectively. Conclusions The main findings from this systematic review were balance training provided the most consistent improvements in self-reported function for patients with CAI.
Annals Graphic Medicine - The Moment
Authors: Lucia Briatore, Ilaria Pozzi
Journal: Annals of Internal Medicine (2016)

Web Exclusives1 November 2016Annals Graphic Medicine - The MomentFREELucia Briatore, MD, PhD and Ilaria PozziLucia Briatore, MD, PhDSearch for more papers by this author and Ilaria PozziSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/G16-0017 SectionsAboutVisual AbstractPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Download figure Download PowerPoint Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=G16-0017.Author/Illustrator Information: Lucia Briatore, MD, PhD, is an internist and diabetologist working in Pietra Ligure, Savona, Italy. Ilaria Pozzi is a freelance illustrator in Savona, Italy.Corresponding Author: Lucia Briatore, MD, PhD, ASL 2 Savonese, via XXV Aprile, Pietra Ligure 17027, Italy; e-mail, [email protected]com.Author Contributions: Conception and design: L. Briatore, I. Pozzi.Drafting of the article: I. Pozzi.Final approval of the article: L. Briatore, I. Pozzi.Written by Lucia Briatore, MD, PhD, and illustrated by Ilaria Pozzi. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 2016Volume 165, Issue 9Page: W13-W14KeywordsConflicts of interestDisclosureHealth care ePublished: 1 November 2016 Issue Published: 1 November 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Abstract 5001: High dose IL-2 (HDIL-2) results in increased PD-1 expression on CD45RA-CCR7-CD8+ and CD45RA-CCR7-CD4+ T cells in melanoma patients
Authors: Maggie L. Diller, Susan Maio, Cabell E. Eysmans, David Lawson, Keith A. Delman, Ragini R. Kudchadkar, Mandy L. Ford
Journal: Cancer Research (2015)

Abstract Introduction: HDIL-2 is associated with long-term remissions in Stage IV melanoma in less than 10% of patients. We hypothesized that HDIL-2 alters the expression of PD-1 on T cell subsets in melanoma patients. Methods: Samples were collected after written consent under an IRB approved protocol. Peripheral blood was collected at baseline and serially post-treatment at 24, 48, 72, and 96 hours from 6 patients with advanced stage melanoma undergoing HDIL-2. All patients were treatment naïve with regards to anti-PD-1 and anti-CTLA4 therapies. PBMCs were isolated and underwent intracellular cytokine and extracellular receptor staining. Co-signaling molecule expression was analyzed via flow cytometry. Statistical analysis was performed using paired t tests via Prism 6.0e software. Results: HDIL-2 was associated with a preferential loss of effector memory (TEM; CD45RA-CCR7-) CD4+ and CD8+ T cells and a relative enrichment of naïve (CD45RA+CCR7+) CD4+ and CD8+ T cells in the blood during the first 3 days of treatment. On day 4, frequencies of CD4+ and CD8+ TEM had returned to baseline. Importantly, PD-1 expression was significantly increased on day 4 post-treatment on CD8+ TEM relative to baseline (22.1% +/- 13.2% on day 4 compared to 13.4% +/- 7.4% at baseline; p = 0.04). This finding was also true for CD4+ TEM (11.4% +/- 6.1% on day 4 compared to 6.1% +/- 3.7% at baseline, p = 0.04). PD-1 expression was not statistically different within the other CD4+ and CD8+ memory T cell subsets including: naïve, central memory (CD45RA-CCR7+), or TEMRA (CD45RA+CCR7-) lymphocytes. Conclusion: These results demonstrate that HDIL-2 is associated with an increase in expression of PD-1 on TEM cells in patients with advanced melanoma suggesting a possible mechanism contributing to the limited efficacy of HDIL-2 in most patients. It is known that TEM cells function by migrating to peripheral tissues, and that CD8+ TEM cells are found specifically in metastatic melanoma lesions. Importantly, our findings illustrate a potential synergistic effect between HDIL-2 and PD-1 blockade. Upregulation of PD-1 and the chronologic pattern in which its expression changes under the effects of HDIL-2 provide a mechanistic rationale for testing the combination of HDIL-2 and anti-PD-1 therapy in patients with advanced melanoma. Citation Format: Maggie L. Diller, Susan Maio, Cabell E. Eysmans, David Lawson, Keith A. Delman, Ragini R. Kudchadkar, Mandy L. Ford. High dose IL-2 (HDIL-2) results in increased PD-1 expression on CD45RA-CCR7-CD8+ and CD45RA-CCR7-CD4+ T cells in melanoma patients. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5001. doi:10.1158/1538-7445.AM2015-5001
Safety, Pharmacokinetics (PK), Metabolism, and Mass Balance of [14C]-AMN107, a Novel Aminopyrimidine Inhibitor of Bcr-Abl Tyrosine Kinase, in Healthy Subjects.
Authors: Mark Kagan, Phi Tran, Volker Fischer, Paula Savage, Tom Smith, Chiaki Tanaka, Horst Schran, Milind Narurkar, Leila Alland
Journal: Blood (2005)