tbuckley/cabot-search huggingface dataset:
Abstract P3-13-02: Surcigal management of ipsilateral breast tumor recurrence
Authors: T Kolben, TM Schwarz, C Goess, C Blume, T Degenhardt, J Engel, R Wuerstlein, N Ditsch, N Harbeck, S Kahlert
Journal: Cancer Research (2016)

Abstract PURPOSE Approximately 10-15% of breast cancer patients treated by breast conserving surgery (BCS) and adjuvant radiotherapy (RT) will develop ipsilateral breast tumor recurrence (IBTR). International guidelines suggest total mastectomy as treatment of choice for IBTR following lumpectomy and RT. Nevertheless, there is evidence that second BCS might be equally sufficient. PATIENTS AND METHODS Patients with IBTR diagnosed between 1990 and 2014 after BCS and RT were included (n=170). 34.1% women underwent secondary BCS, whereas 65.9% were treated by mastectomy. We determined predictive factors for time to local progression (TTP), disease free survival (DFS), and overall survival (OS) comparing these two groups. RESULTS Median follow-up after primary IBTR was 49 months (59 months for patients still alive at time of analysis). Five-year IBTR-free rate after secondary BCS was 77.6% (SD±6.1%) and 75.0% (SD±4.5%) for patients after mastectomy. Five-year DFS was 57.3% (SD±8.2%), and 61.9% (SD±5.5%), five-year OS was 84.7% (SD±5.8%), and 72.6% (SD±5.1%), respectively. Prior adjuvant systemic therapy, muscular invasion, and skin infiltration were independent significant risk factors for a shorter TTP. Additionally, lymphovascular infiltration (LVI) in the IBTR increased the risk for a shorter DFS. LVI, muscular invasion, and skin infiltration were identified as independent significant risk factors for a shorter OS. CONCLUSION No significant difference in local control, DFS, and OS was seen between IBTR patients treated either by secondary BCS or mastectomy. Our data suggest that secondary BCS for IBTR patients after initial BCS and RT is feasible in selected patients. Citation Format: Kolben T, Schwarz TM, Goess C, Blume C, Degenhardt T, Engel J, Wuerstlein R, Ditsch N, Harbeck N, Kahlert S. Surcigal management of ipsilateral breast tumor recurrence. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-13-02.
Follow-up report on the outcome of patients relapsing after autologous marrow transplantation for malignant lymphoma.
Authors: C H Weaver, F Appelbaum, F B Petersen, C D Buckner
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.4.812 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8478675 Follow-up report on the outcome of patients relapsing after autologous marrow transplantation for malignant lymphoma. C H WeaverxC H WeaverSearch for articles by this author , F AppelbaumxF AppelbaumSearch for articles by this author , F B PetersenxF B PetersenSearch for articles by this author , C D BucknerxC D BucknerSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.4.812 PDF "Follow-up report on the outcome of patients relapsing after autologous marrow transplantation for malignant lymphoma.." Journal of Clinical Oncology, 11(4), pp. 812–813© 1993 by American Society of Clinical Oncology
MM-008: A Phase 1 Trial Evaluating Pharmacokinetics and Tolerability of Pomalidomide + Low-Dose Dexamethasone in Patients with Relapsed or Refractory and Refractory Multiple Myeloma and Renal Impairment
Authors: Jeffrey Matous, David S Siegel, Sagar Lonial, R. Donald Harvey, Claudia Kasserra, Yan Li, Min Chen, Thomas Doerr, Lars Sternas, Mohamed H. Zaki, Christian Jacques, Jatin J. Shah
Journal: Blood (2014)
Symptom correlates of vulnerability to backward masking in schizophrenia
Authors: M Green, E Walker
Journal: American Journal of Psychiatry (1986)

The authors used the backward-masking procedure to investigate visual information processing in schizophrenic and bipolar patients, determining the critical interstimulus interval at which the masked target could be identified for each subject. Multiple regression analysis revealed that a negative symptom rating was a significant predictor of this interval among schizophrenic patients: greater negative symptoms were associated with longer intervals. Positive symptom ratings were not predictive of performance. Symptom ratings did not predict performance of bipolar patients. Group comparisons revealed that schizophrenic patients who had mixed positive and negative symptoms had significantly longer intervals than normal control subjects did. These results have implications for theories of information processing in schizophrenia.
All-Trans Retinoic Acid Delays the Differentiation of Primitive Hematopoietic Precursors (lin−c-kit+Sca-1+) While Enhancing the Terminal Maturation of Committed Granulocyte/Monocyte Progenitors
Authors: Louise E. Purton, Irwin D. Bernstein, Steven J. Collins
Journal: Blood (1999)
The tail of the epidemic and the challenge of tracing the very last Ebola case
Authors: K Kaasik-Aaslav, D Coulombier
Journal: Eurosurveillance (2015)

Preview this article: The tail of the epidemic and the challenge of tracing the very last Ebola case, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/20/12/art21075-en-1.gif
Venous Blood Ammonia Can Be Associated With Cerebral Blood Flow in Hepatic Encephalopathy
Authors: Gitte Dam, Susanne Keiding, Ole L. Munk, Peter Ott, Hendrik Vilstrup, Lasse K. Bak, Helle S. Waagepetersen, Arne Schousboe, Michael Sørensen
Journal: Hepatology (2012)

We appreciate the interest by Zheng et al. in our recent paper.1 However, we have serious concerns regarding their suggestion that venous blood ammonia and cerebral blood flow (CBF; mL blood/mL brain tissue/min) are correlated in hepatic encephalopathy (HE) and that magnetic resonance imaging (MRI) can replace positron emission tomography (PET) for studies of cerebral ammonia metabolism. First, the main purpose of our study was to test the hypotheses of decreased CBF and cerebral metabolic rate of oxygen (CMRO2; μmol/mL brain tissue/min) and increased arterial blood ammonia and cerebral metabolic rate of ammonia (CMRA; μmol/mL brain tissue/min) during HE in a paired study. Our findings showed that CBF and CMRO2 were significantly lower during HE than after recovery and that arterial blood ammonia was significantly higher, whereas CMRA was unchanged. Zheng et al. suggest that, based on observations in a single patient before and after transjugular intrahepatic portosystemic shunt (TIPS), CBF may be negatively correlated with venous blood ammonia concentration. To this point, as seen in Fig. 4C in our study,1 our paired observations in seven subjects examined during and after recovery from HE showed no significant relationship between changes in CBF and arterial ammonia blood concentration. In addition, in another paired study from our group,2 individual changes in CBF after TIPS (n = 9) did not correlate with changes in arterial blood ammonia. An important issue in this context is that measurements of ammonia concentration in venous blood cannot replace measurements in arterial blood for pathophysiological studies, because it is the arterial blood concentration to which the brain is exposed, and the relationship between arterial and venous blood concentrations of ammonia is unpredictable. In fact, venous blood ammonia can be normal in spite of arterial hyperammonemia.3 Accordingly, we contend that MRI and venous blood ammonia measurements cannot replace PET and arterial ammonia measurements for studies of CMRA. Gitte Dam M.D., Ph.D.1 Susanne Keiding M.D., M.D.Sc.1,2 Ole L. Munk Ph.D.1 Peter Ott M.D., M.D.Sc.2 Hendrik Vilstrup M.D., M.D.Sc.2 Lasse K. Bak Ph.D.3 Helle S. Waagepetersen Ph.D.3 Arne Schousboe D.Sc.3 Michael S⊘rensen M.D., Ph.D.1,2 1Department of Nuclear Medicine & PET Center, Aarhus University Hospital, Aarhus, Denmark 2Department of Hepato-Gastroenterology, Aarhus University Hospital, Aarhus, Denmark 3Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
Endoscopic Mucosal Resection Scissors for the Treatment of Early Gastric Cancer
Authors: M Miyashita, T Tajiri, H Maruyama, H Makino, T Nomura, K Sasajima, K Yamashita
Journal: Endoscopy (2003)

Endoscopic mucosal resection (EMR) is currently a common treatment for superficial gastrointestinal tumors. We have developed new EMR scissors for superficial lesions in the esophagus and stomach. These scissors have stainless steel blades with an electrocoagulation device for hemostasis. We report a case in which superficial gastric cancer was treated by means of the EMR scissors. The lesion was removed using the scissors and no major complication was encountered. EMR scissors can be used for endoscopic resection of superficial lesions of the esophagus and stomach.
Familial aggregation of emotional and behavioral problems of childhood in the general population
Authors: P Szatmari, M H Boyle, D R Offord
Journal: American Journal of Psychiatry (1993)

This study sought to evaluate the existence and implications of familial aggregation of emotional and behavioral problems of childhood in a general population sample.The children included in the study were chosen with the use of a sampling technique that identified households in which there were two or more children aged 4-16 years living at home at the time of the survey. Ratings on checklists of emotional and behavioral problems were obtained from parents, teachers of children in elementary school, and the children themselves if they were adolescents aged 12-16. Children were classified as having problems if their scores on scales of conduct, attention deficit, or emotional problems were in the top 10% of the distribution of scores from any informant.There was evidence for familial aggregation of these problems, particularly conduct and emotional problems. However, this was largely derived from the parents' reports of symptoms, not the teachers' or adolescents' reports. The degree of familial aggregation varied according to certain sibship characteristics and patterns of comorbidity.Familial aggregation of emotional and behavioral problems does exist in a community population and is not simply an artifact of clinic attendance.
Task shifting rheumatic heart disease screening to non-experts
Authors: Anita Saxena
Journal: The Lancet Global Health (2016)

Rheumatic heart disease (RHD) affects over 32 million people worldwide; the vast majority of patients are in low-income and middle-income countries.1 It is a leading cause of premature mortality in children and young adults living in endemic regions. Patients with RHD often present in an advanced stage of the disease when treatment options are limited. On the other hand, patients with milder forms of the disease, for whom the benefits of treatment are proven2 are difficult to detect owing to lack of symptoms.
Sex distribution of DSM-III personality disorders in psychiatric outpatients
Authors: J Reich
Journal: American Journal of Psychiatry (1987)

The author determined the sex distribution of 170 outpatients with a DSM-III diagnosis of personality disorder measured by standardized instruments and compared his findings with DSM-III predictions. They confirmed the prediction of more women diagnosed as having histrionic personality disorder and more men diagnosed as having paranoid, compulsive, and antisocial personality disorders. The predicted excess of women diagnosed as having borderline and dependent personality disorders was not confirmed.
The Carcinogenic Action of 9,10-Dimethyl-1,2-Benzanthracene on the Skin and Subcutaneous Tissues of the Mouse, Rabbit, Rat, and Guinea Pig&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: I. Berenblum
Journal: JNCI Journal of the National Cancer Institute (1949)

The Carcinogenic Action of 9,10-Dimethyl-1,2-Benzanthracene on the Skin and Subcutaneous Tissues of the Mouse, Rabbit, Rat, and Guinea Pig Get access I. Berenblum I. Berenblum Oxford University Research Centre of the British Empire Cancer Campaign, Oxford, England Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 167–174, https://doi.org/10.1093/jnci/10.1.167 Published: 01 August 1949 Article history Received: 17 May 1949 Published: 01 August 1949
Abstract P4-01-04: Immunohistochemical and histological features of mammographic dense and non-dense tissue in breast cancer patients
Authors: CC dos Santos, P Marshall, R Torresan, E Tinóis, G Duarte, S Teixeira
Journal: Cancer Research (2016)

Abstract Objective: We investigated immunohistochemical and histological composition of dense and non-dense breast tissue in 18 women undergoing mastectomy as the initial treatment for breast cancer. Materials and Methods: In each mammogram, we localized the dense and the non-dense areas. We used a localization technique based on a linear approximation method with interpolation of mammogram images and breast pictures. The selected areas were retrieved during mastectomy and analyzed. Results: Estrogen and progesterone receptors, Ki-67 and CD-34, were equally expressed in both tissues, as well as the percentage composition of fat. The percentage compositions of brownish spots among dense and non-dense tissues were significantly different (p = 0.0226). The number of terminal ductal lobular units was higher for dense than for non-dense breast tissues (p = 0.0019). In the non-dense breast tissue, there were no proliferative lesions with atypia, while we found flat epithelial atypia in 3 of the dense areas evaluated. Proliferative lesions without atypia and non-proliferative lesions were found in both tissues, but they were more frequent in dense than in non-dense breast tissues (23.5% vs 11.8%, p = 0.0455, and 17.6% vs 2.9%, p = 0.0253, respectively). Fibrosis was more frequently extensive or moderate in dense tissue, while it was predominantly mild in non-dense tissue (p = 0.03). Conclusion: There was no difference in the expression of the estrogen and progesterone receptors, Ki-67 and CD-34, in the dense and non-dense tissue areas in breast-cancer women. In addition, both stroma fibrosis and epithelial proliferation were responsible for higher mammographic density. Citation Format: dos Santos CC, Marshall P, Torresan R, Tinóis E, Duarte G, Teixeira S. Immunohistochemical and histological features of mammographic dense and non-dense tissue in breast cancer patients. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-01-04.
A Very Greedy Drug: Cocaine in Context, by Jason Ditton, Richard Hammersley, Samuel Philips, Alasdair Forsyth, Furzana Khan for the
Authors: C. L Masson, A. L Copeland, J. L Sorensen
Journal: BMJ (1997)

Jason Ditton, Richard Hammersley, Samuel Philips, Alasdair Forsyth,

Furzana Khan for the Scottish Cocaine Research Group /

Harwood Academic, £11, pp 151 /

ISBN 3 7186 5904 2

In 1989 a cocaine “crisis” or “panic” occurred in Britain regarding widespread use of crack-cocaine and its devastating consequences. There was fear that the United States' drug problem would spread to Britain's drug scene, with the same harmful effects. In response the Scottish Cocaine Research Group was established “to see whether any Scottish cocaine users existed” and, if they did, to see whether they were uncontrolled, high dose users or …
I. Management of the Unconscious Patient
Authors: S Locke
Journal: New England Journal of Medicine (1966)

At the Boston City Hospital, with the arrival of each new generation of interns, a series of lectures is given on the management of medical emergencies. This series has been sponsored by the First and Third (Tufts) Medical Services under the direction of Dr. Fernando Biguria, and all the medical services have taken part. The lectures continue to be among the most popular and valuable conferences held during the year. Because of this, the Journal, has arranged a similar series, many of the articles being written by participants in the Boston City Hospital lecture course, with the hope that they may be helpful to all physicians, but especially to the young men and women who are now eagerly awaiting their internship this July.
Specificity of granular IgM deposition in folliculosebaceous units and sweat gland apparatus in direct immunofluorescence (DIF) of lupus erythematosus
Authors: Amira Elbendary, Cheng Zhou, Manuel Valdebran, Yan Yu, AbdAllah Gad, Eun Ji Kwon, Dirk M. Elston
Journal: Journal of the American Academy of Dermatology (2016)
Breast self examination training and counseling as motivation strategies for breast awareness and participation in breast cancer screening programs
Authors: A. Artmann, M. Heyne, M. Kiechle, N. Harbeck
Journal: Journal of Clinical Oncology (2006)

1027 Background: In Germany, the particpation rate in gynecologic cancer and the Bavarian breast cancer screening program is only about 30%. Therefore, the impact of counseling and raising confidence in breast self examination (BSE) by a structured BSE training on breast awareness, acceptance of screening offer, and participation rate was evaluated. For evaluation of the training quality, specified MammaCare data sheets and questionnaires were used. Method: Since 2003, 167 women (mean age 35 y; range 19–65 y; 61% ≥40 y) got intensive breast cancer counceling and were professionally trained in MammaCare BSE; 41% had positive breast cancer family history. In their beginner’s course, trainees got general BSE information, covering breast anatomy, breast symptoms, breast cancer screening and therapy. Participants practised BSE, after training on tactually accurate silicone breast models with simulated lumps in order to discriminate normal nodularity from lumps. After 3 months, the supervision sessions included BSE evaluation and - again - professional instruction. In a model exam false positive and negative findings were documented. In breast exams, performance technique and breast tissue coverage were assessed. At both initial sessions and after 12 months, questionnaires on BSE practice, experience, and compliance, cancer worry, acceptance and participation at cancer screening programs were evaluated. Results: Breast cancer worry, anxiety, and lack of information were the main reasons for program participation. Within 3 months after the base course, mean decrease of breast cancer worry was about 95%. Participation in gynecologic and breast cancer screening (≥40 y) more than doubled (94% and 86%). Even after 12 months, these numbers remain consistent. 80% of participants practice BSE monthly, and 46% reported changes in lifestyle regarding nutrition and obesity. Conclusions: Our approach emphasizes importance of self confidence and awareness for participation in cancer screening, also in women with breast cancer family history. Counseling, BSE re-evaluation and reinforcement are correlated with decreased breast cancer worry, a main barrier against participation in breast and gynecologic cancer screening. [Table: see text]
The Patient‐Oriented Eczema Measure in young children: responsiveness and minimal clinically important difference
Authors: D. M. Gaunt, C. Metcalfe, M. Ridd
Journal: Allergy (2016)

Background The Patient-Oriented Eczema Measure (POEM) has been recommended as the core patient-reported outcome measure for trials of eczema treatments. Using data from the Choice of Moisturiser for Eczema Treatment randomized feasibility study, we assess the responsiveness to change and determine the minimal clinically important difference (MCID) of the POEM in young children with eczema. Methods Responsiveness to change by repeated administrations of the POEM was investigated in relation to change recalled using the Parent Global Assessment (PGA) measure. Five methods of determining the MCID of the POEM were employed; three anchor-based methods using PGA as the anchor: the within-patient score change, between-patient score change and sensitivity and specificity method, and two distribution-based methods: effect size estimate and the one half standard deviation of the baseline distribution of POEM scores. Results Successive POEM scores were found to be responsive to change in eczema severity. The MCID of the POEM change score, in relation to a slight improvement in eczema severity as recalled by parents on the PGA, estimated by the within-patient score change (4.27), the between-patient score change (2.89) and the sensitivity and specificity method (3.00) was similar to the one half standard deviation of the POEM baseline scores (2.94) and the effect size estimate (2.50). Conclusions The Patient-Oriented Eczema Measure as applied to young children is responsive to change, and the MCID is around 3. This study will encourage the use of POEM and aid in determining sample size for future randomized controlled trials of treatments for eczema in young children.
Implantable Pacemaker Powered by Ventricular Contractions
Authors: J H Kennedy, C C Enger, A G Michel
Journal: JAMA (1966)

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