tbuckley/cabot-search huggingface dataset:
THU0608-HPR Nonlinearity and Relevant Thresholds in the Relationship Between Muscle Strength and Activity Limitations in Patients with Knee Osteoarthritis: Results of the AMS-OA Cohort
Authors: L.M. Edelaar, J.H. van Dieën, M. van der Esch, L.D. Roorda, J. Dekker, W.F. Lems, M. van der Leeden
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Muscle weakness is a common symptom of knee osteoarthritis (OA), related to activity limitations such as standing up, walking and stair climbing. In previous work, relationships between muscle strength and activity limitations were modeled as linear. We hypothesized that in a large group of OA patients, nonlinearities can be observed, as well as clinically relevant thresholds. <h3>Objectives</h3> To investigate whether relationships between upper leg muscle strength and activity limitations in patients with knee OA are nonlinear and if so, to determine thresholds for muscle strength at which activity limitations occur. <h3>Methods</h3> Baseline data from 573 patients with knee OA from the Amsterdam-Osteoarthritis (AMS-OA) cohort were used. Upper leg muscle strength (Nm/kg) from the quadriceps and hamstrings was measured isokinetically at a velocity of 60°/second. Activity limitations were measured with the Get Up and Go test (GUG) and Stair-Climb (SC) test, subdivided in time to ascend and descend stairs. First, linear regression analyses were performed to assess the relationships between muscle strength and activity limitations. Subsequently, it was examined whether nonlinear models fit better than linear models. To detect thresholds, linear plus constant models were used. The threshold was defined as the intersection point of both lines. Bootstrapping was performed to estimate the reliability of thresholds. <h3>Results</h3> For the relationships between upper leg muscle strength and activity limitations, nonlinear models fitted the data slightly better than linear models. Exponential models improved the fit by 5.9, 8.2 and 5.2 percentage points for respectively GUG time, time to ascend and descend stairs. The linear plus constant models approached the goodness of fit of the exponential models. Thresholds were 0.93 Nm/kg (95% CI=[0.80;1.05], SEM=0.06), 0.89 Nm/kg (95% CI=[0.77;1.00], SEM=0.06) and 0.97 Nm/kg (95% CI=[0.86;1.09], SEM=0.06) for the relationships with respectively GUG time, time to ascend and time to descend stairs. <h3>Conclusions</h3> Exponential models describe the relationships between muscle strength and activity limitations slightly better compared to linear models. Thresholds were determined using linear plus constant models which approached the fit of the exponential models. Our results are a step towards better understanding of the relationship between muscle strength and activity limitations. Future research is needed to assess the clinical value of the thresholds determined with respect to the effectiveness of strength training in knee OA patients. <h3>Disclosure of Interest</h3> None declared
Administration of recombinant human interleukin-7 to mice induces the exportation of myeloid progenitor cells from the bone marrow to peripheral sites
Authors: K Grzegorzewski, KL Komschlies, M Mori, K Kaneda, N Usui, CR Faltynek, JR Keller, FW Ruscetti, RH Wiltrout
Journal: Blood (1994)
ETIOLOGY OF ACUTE ARTICULAR RHEUMATISM.
Authors: C B PERRY
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RENAL ARTERIAL STENOSIS AND HYPERTENSION—MEDICAL OR SURGICAL MANAGEMENT?
Authors: N T GRISCOM
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Simplified Technique for the T-Globulin Cancer Test
Authors: Chloe Tal, Anilbaran Raychaudhuri, H. Megel, Ronald B. Herbermen, C. R. Buncher
Journal: JNCI Journal of the National Cancer Institute (1973)

A fractionation procedure with perchloric acid was developed to purify T-globulin from cancer serum; this fraction was used to prepare the diagnostic anti-T-globulin serum. The procedure replaced the electrophoretic method for preparation of T-globulin antigen. A serial Serum dilution method, developed for more rapid detection of T-globulin, was comparable in accuracy and precision to the laborious ammonium sulfate method. Both the methods differentiated between clinical cancerous and noncancerous populations. The sensitivities for known and coded cancer samples were 92 and 84%, respectively, when the leukemic population was excluded. Specificities for known and coded NCI noncancerous samples were 92 and 52%, respectively. Leukemia patients generally appeared to yield “false negative” results. The tests, as now performed, cannot be considered a useful diagnostic screen for cancer.
SURGICAL TREATMENT OF MITRAL STENOSIS.
Authors: T J O'NEILL
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0057 Targeting the Neonatal FC Receptor (FCRN) to Mediate Autoantibody Clearance in IgG-Driven Autoimmune Disease
Authors: L.E. Ling, S. Roy, J. Meador, M. Kehry, D. Mekala, S. Tyler, D. Bulik, A. Choudhury, L. Markowitz, B. Schultes, W. Avery, V. Parge, E. Cochran, D. King, G.V. Kaundinya, A.M. Manning
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> IgG autoantibodies mediate autoimmune pathology in a number of autoimmune diseases including rheumatoid arthritis, myasthenia gravis, idiopathic thrombocytopenia purpura, autoimmune skin blistering diseases, neuromyelitis optica, channelopathies, CIDP and SLE. Acute exacerbations and recurrent disease symptoms may benefit from rapid, reversible clearance of these pathogenic autoantibodies. <h3>Objectives</h3> Potent monoclonal antibodies (mAbs) which specifically inhibit IgG-FcRn interaction, but not albumin-FcRn interaction were developed to determine the potential of FcRn blockade to clear IgG and pathogenic autoantibodies to ameliorate autoimmune disease pathology. <h3>Methods</h3> Anti-FcRn blocking mAbs were discovered through a unique somatic hypermutation-based technology, SHM-XEL<sup>tm</sup>. These mAbs displayed affinity subpicomolar binding to human and cynomolgus monkey FcRn and were tested for inhibition of IgG and albumin binding, induction of IgG clearance and optimized for pharmaceutical properties. <h3>Results</h3> High affinity (&lt;100 pM) mAbs were identified which specifically inhibit IgG binding and IgG accumulation in endocytic vesicles in monocytic and endothelial cells. These mAbs demonstrated potent, rapid and reversible induction of IgG clearance in human transgenic FcRn, mouse FcRn null mice and in cynomolgus monkey. FcRn blockade by these antibodies also demonstrated potent efficacy when dosed therapeutically in mouse collagen-induced arthritis. A novel anti-FcRn IgG1, Fc effectorless mAb was chosen for further development preclinical and clinical development. <h3>Conclusions</h3> High potency anti-FcRn blocking monoclonal antibodies can induce rapid clearance of autoantibodies and ameliorate disease activity providing a promising therapeutic approach in IgG-dependent severe rheumatoid arthritis and other IgG autoantibody-driven diseases. <h3>Disclosure of Interest</h3> L. Ling Shareholder of: Momenta, Employee of: Momenta, S. Roy Shareholder of: Momenta, Employee of: Momenta, J. Meador Shareholder of: Momenta, Employee of: Momenta, M. Kehry Employee of: AnaptysBio, D. Mekala Shareholder of: Momenta, Employee of: Momenta, S. Tyler Shareholder of: Momenta, Employee of: Momenta, D. Bulik Shareholder of: Momenta, Employee of: Momenta, A. Choudhury Shareholder of: Momenta, Employee of: Momenta, L. Markowitz Shareholder of: Momenta, Employee of: Momenta, B. Schultes Shareholder of: Momenta, Employee of: Momenta, W. Avery Shareholder of: Momenta, Employee of: Momenta, V. Parge: None declared, E. Cochran Shareholder of: Momenta, Consultant for: Momenta, D. King Employee of: AnaptysBio, G. Kaundinya Shareholder of: Momenta, Employee of: Momenta, A. Manning Shareholder of: Momenta, Employee of: Momenta
Evaluation of the effects of postoperative oral nutrition support on body weight in gastric cancer patients by using an elemental diet: A randomized study.
Authors: Kazuhiro Nishikawa, Kentaro Kishi, Kentaro Inoue, Jin Matsuyama, Yusuke Akamaru, Yutaka Kimura, Shigeyuki Tamura, Ryohei Kawabata, Junji Kawada, Yoshiyuki Fujiwara, Tomono Kawase, Junichi Fukui, Mari Takagi, Atsushi Takeno, Toshio Shimokawa, Hiroshi Imamura
Journal: Journal of Clinical Oncology (2014)

110 Background: Postoperative weight loss causes deterioration in the patient’s quality of life and influences long-term prognosis in gastric cancer patients who have undergone gastrectomy. Moreover, recent retrospective studies indicated postoperative weight loss as a risk factor for premature interruption of S-1 adjuvant chemotherapy. We conducted a prospective randomized controlled study to examine whether the early institution of nutritional support comprising an oral elemental diet (ED) prepared for post-gastrectomy patients with depressed digestive/absorptive function would help prevent postoperative weight loss. Methods: After surgery, patients were randomly assigned to the ED or control groups. The groups were divided according to the surgical methods used (total/distal gastrectomy), clinical stage (≤Ia/&gt;Ia), and patients’ body mass index (&lt;18.5/&gt;18.5). In patients assigned to the ED group (Elental, 300 kcal) was provided in addition to the regular diet from the day starting soft rice diet or equivalent diet to 6–8 weeks after surgery. The primary endpoint was the percentage of body weight change from the pre-surgical body weight to that at 6–8 weeks after surgery. The secondary endpoints were ED adherence, nutrition-related blood parameter changes, and adverse effects. Results: The study included 112 patients from eight hospitals. There was a significant difference in the percentage of body weight loss (%BWL) between the ED and control groups (4.88±3.41% and 6.91±5.06%; P=0.015). Sub-group analysis showed a significant difference in the %BWL in patients who underwent total gastrectomy (5.31±3.43% and 9.11±5.57%; P=0.016). Multivariate analysis demonstrated ED treatment and surgery type as independent factors that affect body weight changes. The mean treatment compliance rate in the 58 ED-group patients was 72.9±33.1%, with a favorable median value of 90.8%. No significant differences were observed in any parameter analyzed, including hematological and non-hematological adverse events, between the two groups. Conclusions: The ED product can prevent postoperative weight loss in gastric cancer patients undergoing gastrectomy. Clinical trial information: 000008056.
Mobile Resistance Factor in Acquired Immunity to Homologous Tissue Transplantation
Authors: Richmond T. Prehn, Joan M. Main
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Mobile Resistance Factor in Acquired Immunity to Homologous Tissue Transplantation Get access Richmond T. Prehn, Richmond T. Prehn National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joan M. Main Joan M. Main National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 537–546, https://doi.org/10.1093/jnci/14.3.537 Published: 01 December 1953 Article history Received: 12 June 1953 Published: 01 December 1953
STAT3-Activated GM-CSFRα Shuttles To The Nucleus and Protects CLL Cells From Apoptosis
Authors: Ping Li, Uri Rozovski, David Harris, Lui Zhiming, Alessandra Ferrajoli, Carlos E. Bueso-Ramos, Inbal Hazan-Halevy, Srdana Grugurevic, William G. Wierda, Jan A. Burger, Susan O'Brien, Stefan H. Faderl, Michael J. Keating, Zeev Estrov
Journal: Blood (2013)
PWE-011 Radiofrequency ablation of symptomatic cervical inlet patch using a through the scope device - a pilot study: Abstract PWE-011 Table 1
Authors: JM Dunn, G Sui, A Angiannsah, T Wong
Journal: Gut (2015)

<h3>Introduction</h3> The Cervical Inlet patch (CIP) is an area of heterotopic gastric mucosa at the proximal oesophagus, which can secrete both acid and mucus. Attributable symptoms include chronic globus sensation and sore throat. Previous studies have demonstrated improvement in symptoms following ablation with argon plasma coagulation.<sup>1,2</sup>The aim of this study was to assess a novel through the scope Radiofrequency Ablation (RFA) catheter, that may be advantageous for this indication. <h3>Method</h3> Ten patients with endoscopically and histologically proven CIP, and symptoms of globus or sore throat, were included in the study. All had laryngoscopy, high resolution manometry and 24-hour dual-channel pH/impedance studies prior to enrolment. An ablation protocol of 3 ablations at 12J/cm<sup>2</sup>, without removal of coagulated tissue between ablations, was employed. Patients were discharged on twice daily proton pump inhibitor (PPI) for 6 weeks, and a follow up endoscopy was undertaken at 3 months. A maximum of 2 RFA sessions, 3 months apart, were allowed. A visual analogue score (VAS; 0–100) was completed at baseline, then at 6 weeks (on PPI), 3 months (off PPI), 6 months and 12 months after treatment. Wilcoxon test was used for statistical analysis. <h3>Results</h3> The mean age was 56 years (+/- 3 years, SEM), 60% male, 80% Causcasian. Barrett’s oesophagus was present in 50%. Mean number of CIP was 2 (range, 1–4) with a median surface area of 2 cm<sup>2</sup>(range, 0.5–14cm<sup>2</sup>). After a median of 2 RFA sessions, 80% achieved complete endoscopic and histological resolution (CR-IP), with &gt;90% visual resolution for remainder. Globus, sore throat and cough were significantly improved from baseline (p &lt; 0.05) (Table 1). There were no strictures or buried glands identified at follow up. <h3>Conclusion</h3> This prospective pilot study demonstrates that RFA using the Barrx<sup>TM</sup>Channel Catheter is safe and effective for treating patients with symptoms of chronic globus sensation, secondary to cervical inlet patch. <h3>Disclosure of interest</h3> J. Dunn Grant/Research Support from: Covidien GI Solutions, G. Sui: None Declared, A. Angiannsah: None Declared, T. Wong: None Declared. <h3>References</h3> Meining A <i>et al</i>. Argon plasma ablation of gastric inlet patches in the cervical esophagus may alleviate globus sensation: a pilot trial. Endosc. 2006;38:566–570 Bajbouj M <i>et al</i>. Argon plasma coagulation of cervical heterotopic gastric mucosa as an alternative treatment for globus sensations. Gastroenterol. 2009;137:440–444
Time-Based Billing
Authors: Kevin Selby, Samuel Edwards
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The War Against Disease
Authors: Gro Harlem Brundtland
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Beta-Carotene as a Photoprotective Agent in Erythropoietic Protoporphyria
Authors: Micheline M. Mathews-Roth, Madhu A. Pathak, Thomas B. Fitzpatrick, Leonard C. Harber, Edward H. Kass
Journal: New England Journal of Medicine (1970)

Three patients with erythropoietic protoporphyria, with elevated levels of porphyrin in blood and stool and with severe photosensitivity on exposure of skin to both sunlight and artificial light were treated with an oral preparation of beta-carotene. After treatment, two of the patients were able to tolerate five to eight hours of sun without experiencing photosensitivity, and the third could tolerate exposure to sun with less discomfort than he had experienced before therapy. When the patients were carotenemic, they also reacted less intensely to artificial light. Beta-carotene appears to counteract photosensitization in the skin of these patients, and carotenoid pigments prevent photosensitization in bacteria, plants and mice. Whether the mechanism of action of carotenes is the same in all cases is not yet known.
CSF dopamine beta-hydroxylase in schizophrenia: associations with premorbid functioning and brain computerized tomography scan measures
Authors: D P van Kammen, M E Kelley, M W Gilbertson, J Gurklis, D T O'Connor
Journal: American Journal of Psychiatry (1994)

The authors attempted to replicate previous findings of relationships of CSF dopamine beta-hydroxylase with premorbid functioning and computerized tomography (CT) scan measures in a new cohort of schizophrenic patients.Data on CSF dopamine beta-hydroxylase-like immunoreactivity and premorbid functioning, as well as CT scans, were obtained in 60 drug-free, male schizophrenic patients and two groups of normal comparison subjects.CSF dopamine beta-hydroxylase did not differ between the comparison subjects and schizophrenic patients. Lower CSF dopamine beta-hydroxylase was associated with better premorbid social functioning and with less prefrontal sulcal widening. Better premorbid school functioning and more years of education, however, were associated with higher CSF dopamine beta-hydroxylase.The association between low CSF dopamine beta-hydroxylase and premorbid functioning was confirmed for social functioning, while the opposite was observed for scholastic performance, suggesting that these are different dimensions. Dopamine beta-hydroxylase modulates the prognosis and potentially the course of schizophrenia without necessarily causing the disorder.