tbuckley/cabot-search huggingface dataset:
Influence of mixed organosilane coatings with variable RGD surface densities on the adhesion and proliferation of human osteosarcoma Saos-2 cells to magnesium alloy AZ31
Authors: Xiaoxi Yang, Afrah Al Hegy, Eric R. Gauthier, Joy Gray-Munro
Journal: Bioactive Materials (2017)

In the last decade, the use of magnesium and its alloys as biodegradable implant materials has become increasingly accepted. However, surface modification of these materials to control the degradation rate in the early stages of healing and improve their biocompatibility is crucial to the successful implementation of magnesium alloy implants in medicine. Cell adhesion and proliferation at the implant surface is a vital factor for successful integration of a biomaterial within the body. Cells accomplish this task by binding to ligands such as the arginine-glycine-aspartic acid peptide sequence (RGD) commonly found on adhesive proteins present in the extracellular matrix. In this paper, we report a biomimetic surface modification strategy involving deposition of a mixed organosilane layer on Mg AZ31 followed by covalent immobilization of RGD peptides through a heterobifunctional cross-linker molecule. Our results indicate that with optimized deposition conditions uniform organosilane coatings were successfully deposited on the Mg AZ31 substrate. Furthermore, we have demonstrated that the surface density of immobilized RGD can be varied by depositing organosilane layers from solutions containing two different organosilanes in specified ratios. Increases in cell adhesion and cell proliferation were observed on the surface modified substrates.
Detection of c-Kit Mutation in Peripheral Blood vs. Bone Marrow Aspirates in Patients with Systemic Mastocytosis: Comparison Study of Pathological and Clinical Laboratory Findings in Patients with and without Detectable c-Kit Mutation in the Peripheral Blood.
Authors: Irina Maric, Jamie Robyn, Weiming Fu, Jennifer Stoddard, Dean D. Metcalfe, Pierre Noel
Journal: Blood (2006)
Combined JAK/STAT5A and BCR-ABL Inhibition Impairs Blast Crisis Chronic Myeloid Leukemia Stem Cell Self-Renewal
Authors: Angela C Court Recart, Daniel J Goff, Anil Sadarangani, Cayla N Mason, Alice Y. Shih, Russell Wall, Heather S. Leu, Wenxue Ma, Hye-Jung Chun, Marco A. Marra, Christian L Barrett, Kelly A Frazer, Catriona Jamieson
Journal: Blood (2012)
Leonard Irving Liebling
Authors: Michael Toseland
Journal: BMJ (2017)

Leonard Irving Liebling (“Len”) was born in West Bridgford, Nottingham, in 1938. His parents were Nathan and Leah, and his older siblings,, Sydney and Fay. Len was the first in his Jewish family to go to university, in Birmingham, where he studied medicine. 

He carried out research on lithium as a treatment for manic depressive psychosis and published an article in Acta Psychiatrica Scandinavica in 1970. Len was a natural listener. His ambition, to become “the …
Array-CGH Identifies Both Common and Subtype-Specific Genomic Aberrations in Marginal Zone Lymphomas
Authors: Andrea Rinaldi, Paola MV Rancoita, Govind Bhagat, Urban Novak, Subhadra Nandula, Vundavalli V. Murty, Maurilio Ponzoni, Silvia Govi, Andres JM Ferreri, Luca Baldini, Randy Gascoyne, Jean Soulier, Catherine Thieblemont, Roberto Marasca, Silvia Franceschetti, Gianluca Gaidano, Vincenzo Canzonieri, Valter Gattei, Fabio Facchetti, Alessandra Tucci, Manuela Mollejo, Miguel A. Piris, Silvia Uccella, Maria Grazia Tibiletti, Stephan Dirnhofer, Francesco Forconi, Ekaterina Chigrinova, Claudio Doglioni, Riccardo Dalla-Favera, Emanuele Zucca, Ivo Kwee, Francesco Bertoni
Journal: Blood (2008)
New Formula for the Differentiation Between Iron Deficiency Anemia and Thalassemic Carrier in Thalassemic Prevalence Areas: A Study in Healthy School-Age Children.
Authors: Nongnuch Sirachainan, Pornchanok Iamsirirak, Chalermkwan Chaiyong, Pimlak Charoenkwan, Praguywan Kadegasem, Werasak Sasanakul, Ampaiwan Chuansumrit
Journal: Blood (2009)
A Phase I Clinical Trial Using Eltrombopag in Patients with Acute Myelogenous Leukemia
Authors: Noelle V. Frey, Elizabeth O. Hexner, David L Porter, James K. Mangan, Alison W. Loren, Joseph Hatem, Adam Bagg, Alexander E Perl, Donald E Tsai, Courtney D. DiNardo, Daniel Heitjian, Selina M. Luger, Martin Carroll
Journal: Blood (2012)
PML-RARα Repressed Microrna 126 Mediates Differentiation in Acute Promyelocytic Leukemia By Targeting the Protooncogene C-Myb
Authors: Cindy Schödel, Jens-Uwe Hartmann, Dennis Gerloff, Daniela Braeuer-Hartmann, Christiane Katzerke, Alexander Arthur Wurm, Carsten Müller-Tidow, Daniel G. Tenen, Dietger Niederwieser, Gerhard Behre
Journal: Blood (2014)
Impact on Response and Survival of DNA Repair Single Nucleotide Polymorphisms In Relapsed or Refractory Multiple Myeloma Patients Treated with Thalidomide
Authors: Carlos Fernández de Larrea, María Teresa Cibeira, Alfons Navarro, Tania Díaz, Dolors Fuster, Natalia Tovar, Laura Rosiñol, Mariano Monzó, Joan Blade
Journal: Blood (2010)
Stroke Diagnosis and Treatment in the Emergency Department
Authors: Eugenia Rota, Nicola Morelli, Paolo Immovilli
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Identification of the PML-RARα Associated DNA Methylome Using Reduced Representation Bisulfite Sequencing in Primary Patient Samples
Authors: Christian Rohde, Till Schoofs, Katja Hebestreit, Hans-Ulrich Klein, Anika Witten, Monika Stoll, Eva Lengfelder, Wolf-Karsten Hofmann, Peter Schlenke, Stefanie Göllner, Thomas Büchner, Maria Cristina Sauerland, Steffen Koschmieder, Wolfgang E. Berdel, Martin Dugas, Carsten Müller-Tidow
Journal: Blood (2011)
Aberrant DNA Methylation of a Cell Cycle Regulatory Pathway Composed of p73, p15 and P57kip2 Is Associated with Poor Prognosis in Adult Patients with Philadelphia Chromosome Negative Acute Lymphocytic Leukemia (ALL).
Authors: Hui Yang, Koyu Hoshino, Lianchun Xiao, Gary Rosner, Guillermo Garcia-Manero
Journal: Blood (2005)
Persistence of Disease‐Associated Anti–Citrullinated Protein Antibody–Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission
Authors: Adam J. Pelzek, Caroline Grönwall, Pamela Rosenthal, Jeffrey D. Greenberg, Mandy McGeachy, Larry Moreland, William F. C. Rigby, Gregg J. Silverman
Journal: Arthritis & Rheumatology (2017)

In rheumatoid arthritis (RA), autoreactive B cells are pathogenic drivers and sources of anti-citrullinated protein antibodies (ACPAs) that are a diagnostic biomarker and predictor of worse long-term prognosis. Yet, the immunobiologic significance of persistent ACPA production at the cellular level is poorly understood. This study was undertaken to investigate the representation of ACPA-expressing switched-memory B cells in RA.In a cross-sectional study of RA patients, we investigated the presence of continued defects in immune homeostasis as a function of disease activity. Using an enzyme-linked immunosorbent assay (ELISA) and a sensitive multiplex bead-based immunoassay, we characterized fine binding antibody specificities in sera, synovial fluid (SF), and B cell culture supernatants. In this manner, we determined the frequency and epitope reactivity patterns of ACPAs produced by SF B cells and switched-memory blood B cells and compared the latter to serum ACPA levels and disease activity scores.Cultured B cells from SF were shown to spontaneously secrete ACPAs, while constitutive IgG autoantibody production by peripheral blood mononuclear cells (PBMCs) was substantially less frequent. After in vitro stimulation, PBMCs secreted IgG ACPA that was overwhelmingly from switched-memory B cells, across all patient groups treated with methotrexate and/or a tumor necrosis factor inhibitor. Intriguingly, the frequencies of ACPA-expressing switched-memory B cells significantly correlated with serum IgG anti-cyclic citrullinated peptide 3 (r = 0.57, P = 0.003). Moreover, treatment-induced clinical remission had little or no effect on the circulating burden of switched-memory ACPA-expressing B cells, in part explaining the continued dysregulation of humoral immunity.Our findings rationalize why therapeutic cessation most often results in disease reactivation and clinical flare. Hence, a clinical disease activity score is not a reliable indicator of the resolution of pathologic recirculating B cell autoimmunity.
Planned First Safety and Efficacy Analysis of Oral Fludarabine Combined with Subcutaneous Alemtuzumab in 2nd Line Therapy of B-Chronic Lymphocytic Leukaemia (B-CLL): The FLUSALEM Study.
Authors: Alexander Egle, Inge Tinhofer, G. Russ, C. Rass, Richard Greil
Journal: Blood (2006)
Findings of Whole Body Computed Tomography Compared to Conventional Skeletal Survey in Patients with Monoclonal Plasma Cell Disorders - a Study of the International Myeloma Working Group
Authors: Jens Hillengass, Lia A. Moulopoulos, Stefan Delorme, Vassilis Koutoulidis, Thomas Hielscher, Jessica Engelhart, Matthew T. Drake, S. Vincent Rajkumar, Brian Oestergaard, Niels Abildgaard, Maja Hinge, Torben Plesner, Yasuhito Suehara, Kosei Matsue, Jo Caers, Nadia Withofs, Meletios A Dimopoulos, Hartmut Goldschmidt, Suzanne Lentzsch, Brian G Durie, Evangelos Terpos
Journal: Blood (2016)
Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation
Authors: Katja G. Weinacht, Louis-Marie Charbonnier, Fayhan Alroqi, Ashley Plant, Qi Qiao, Hao Wu, Clement Ma, Troy R. Torgerson, Sergio D. Rosenzweig, Thomas A. Fleisher, Luigi D. Notarangelo, Imelda C. Hanson, Lisa R. Forbes, Talal A. Chatila
Journal: Journal of Allergy and Clinical Immunology (2017)
Intracranial Tuberculoma in a Patient With Untreated Human Immunodeficiency Virus
Authors: Ethan Meltzer, Khaled Moussawi
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Fibrin(ogen) Exacerbates Inflammatory Joint Disease Via a Mechanism Linked to Its αMβ2 Binading Motif.
Authors: Matthew J. Flick, Christine M. La Jeunesse, Kathryn E. Talmage, David P. Witte, Joseph Palumbo, Malinda D. Pinkerton, Sherry Thornton, Jay L. Degen
Journal: Blood (2006)
Long-Term Survival after Reduced Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation in AML-Patients Is Consistently Sustained and Influenced by Donor Type Selection.
Authors: Herbert G. Sayer, Lars-Olof Muegge, Sebastian Scholl, Kristina Schilling, Anne Klink, Volker Schmidt, Klaus Hoeffken
Journal: Blood (2007)
Interactions Between Total Nucleated and CD34 Cell Dose and Their Impact on Outcomes After Single and Double Unrelated Cord Blood Transplantation for Patients with Hematological Malignancies. An Analysis on Behalf of Societe' Française De Greffe De Moelle Et Therapie Cellulaire (SFGM-TC) and Eurocord
Authors: Mauricette Michallet, Renato L.G. Cunha, Gérard Michel, Gérard Socié, Mohamad Mohty, Bernard Rio, Didier Blaise, Anne Sirvent, Reza Tabrizzi, Pierre Bordigoni, Eric Deconinck, Ibrahim Yakoubagha, Jean-François Rossi, Natacha Maillard, Mohamad Sobh, Federico Garnier, Annalisa Ruggeri, Eliane Gluckman, Vanderson Rocha
Journal: Blood (2010)
Polymorphisms in Genes of Folate Metabolism and Response to High-Dose Methotrexate in Patients with Primary Central Nervous System Lymphoma.
Authors: Stefan Knop, Juergen Loeffler, Michael Steffens, Markus Guenther, Agnieszka Korfel, Michael Weller, Holger Hebart, Hermann Einsele, Ulrich Herrlinger
Journal: Blood (2005)
Investigation of the potential application of sodium bentonite as an excipient in formulation of sustained release tablets
Authors: Jamal Alyoussef Alkrad, Reham Abu Shmeis, Iyad Alshwabkeh, Husam Abazid, Mohammad Amin Mohammad
Journal: Asian Journal of Pharmaceutical Sciences (2017)

In this study, the application of sodium bentonite (SB) in formulation of tablets prepared by direct compression for oral administration was tested. Three different model drugs with different solubilities: paracetamol, diclofenac sodium and metformin HCl were tested. Each drug was mixed with SB at ratio of 50% and the mixtures were subsequently compressed. Compatibility studies were conducted using both Deferential Scanning Calorimeter (DSC) and Fourier Transform Infrared Spectroscopy (FTIR). The dissolution profile for each drug was determined in USP-buffers at different time intervals. Diclofenac sodium in pH 6.8 buffer and paracetamol in both pH 6.8 and pH 4.5 buffers showed extended release. However, metformin HCl showed immediate release at the different pH values. The study showed that using SB was possible to prepare tablets with different release profiles. However, these profiles differ depending on dissolution media and drug type.
Notice of Data Errors
Authors: Carol J. Baker
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Encoraging Results after Alternative Donor Transplantation for Myelodysplastic Syndrome.
Authors: Franco Locatelli, Adrienne Moreno-Madureira, Pierre Teira, Mary Eapen, Mei-Jie Zhang, Stella M. Davies, Alessandra Picardi, Ann E Woolfrey, Ka Wah Chan, Gerard Socie, Ajay J. Vora, Yves Bertrand, Joanne Kurtzberg, Carmen Bonfim, Eliane Gluckman, Charlotte M Niemeyer, Vanderson Rocha
Journal: Blood (2008)
Analysis of 54 Follicular Lymphomas By Whole Exome Sequencing Identifies Multiple Novel Recurrently Mutated Pathways
Authors: Sami N. Malek, Denzil Bernard, Zhang Xiao Ying, Luke F. Peterson, Nisar A. Amin, Shaomeng Wang, Kamlai Saiya-Cork, Mark S. Kaminski, Alfred Chang
Journal: Blood (2015)
Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis
Authors: Parambir S. Dulai, Siddharth Singh, Janki Patel, Meera Soni, Larry J. Prokop, Zobair Younossi, Giada Sebastiani, Mattias Ekstedt, Hannes Hagstrom, Patrik Nasr, Per Stal, Vincent Wai‐Sun Wong, Stergios Kechagias, Rolf Hultcrantz, Rohit Loomba
Journal: Hepatology (2017)

Liver fibrosis is the most important predictor of mortality in nonalcoholic fatty liver disease (NAFLD). Quantitative risk of mortality by fibrosis stage has not been systematically evaluated. We aimed to quantify the fibrosis stage–specific risk of all‐cause and liver‐related mortality in NAFLD. Through a systematic review and meta‐analysis, we identified five adult NAFLD cohort studies reporting fibrosis stage–specific mortality (0‐4). Using fibrosis stage 0 as a reference population, fibrosis stage–specific mortality rate ratios (MRRs) with 95% confidence intervals (CIs) for all‐cause and liver‐related mortality were estimated. The study is reported according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses statement. Included were 1,495 NAFLD patients with 17,452 patient years of follow‐up. Compared to NAFLD patients with no fibrosis (stage 0), NAFLD patients with fibrosis were at an increased risk for all‐cause mortality, and this risk increased with increases in the stage of fibrosis: stage 1, MRR = 1.58 (95% CI 1.19‐2.11); stage 2, MRR = 2.52 (95% CI 1.85‐3.42); stage 3, MRR = 3.48 (95% CI 2.51‐4.83); and stage 4, MRR = 6.40 (95% CI 4.11‐9.95). The results were more pronounced as the risk of liver‐related mortality increased exponentially with each increase in the stage of fibrosis: stage 1, MRR = 1.41 (95% CI 0.17‐11.95); stage 2, MRR = 9.57 (95% CI 1.67‐54.93); stage 3, MRR = 16.69 (95% CI 2.92‐95.36); and stage 4, MRR = 42.30 (95% CI 3.51‐510.34). Limitations of the study include an inability to adjust for comorbid conditions or demographics known to impact fibrosis progression in NAFLD and the inclusion of patients with simple steatosis and nonalcoholic steatohepatitis without fibrosis in the reference comparison group. Conclusion: The risk of liver‐related mortality increases exponentially with increase in fibrosis stage; these data have important implications in assessing the utility of each stage and benefits of regression of fibrosis from one stage to another. (H epatology 2017;65:1557‐1565).
Lipid Droplet Biogenesis and Function in the Endothelium
Authors: Andrew Kuo, Monica Y. Lee, William C. Sessa
Journal: Circulation Research (2017)

Rationale: Fatty acids (FA) are transported across the capillary endothelium to parenchymal tissues. However, it is not known how endothelial cells (EC) from large vessels process a postprandial surge of FA. Objective: This study was designed to characterize lipid droplet (LD) formation in EC by manipulating pathways leading to the formation and degradation of LD. In addition, several functions of LD-derived FA were assessed. Methods and Results: LD were present in EC lining the aorta after the peak in plasma triglycerides initiated by a gavage of olive oil in mice, in vivo. Similarly, in isolated aorta, oleic acid treatment generates LD in EC ex vivo. Cultured EC readily form LD largely via the enzyme DGAT (diacylglycerol O-acyltransferase 1) and degrade LD via ATGL (adipocyte triglyceride lipase) after FA loading. Functionally, LD-derived FA are dynamically regulated and function to protect EC from lipotoxic stress and provide FA for metabolic needs. Conclusions: Our results delineate endothelial LD dynamics for the first time in vivo and in vitro. Moreover, LD formation protects EC from lipotoxic stress, regulates EC glycolysis, and provides a source of FA for adjacent cells in the vessel wall or tissues.
The Dual SRC/ABL Kinase Inhibitor BMS-354825 Potently Inhibits the Growth of Myeloid Leukemic Cells Characterized by FLT3-ITD Expression, GM-CSF Dependency, or G-CSF Responsiveness Via an ABL-Independent Mechanism.
Authors: Jukka Kanerva, Ogonna Nwawka, Kevin Hwang, Francis Y. Lee, Seth J. Corey
Journal: Blood (2004)
Severe Factor V Deficiency Caused by a Novel Compound Heterozygous Mutation: Factor V G1617V and 1-Bp Insertion
Authors: Keiko Shinozawa, Yuri Okimoto, Kagehiro Amano, Harumi Kakuda, Takeshi Hagiwara, Takashi Suzuki, Hiroshi Inaba, Katsuyuki Fukutake
Journal: Blood (2011)
MR spectroscopy compared with DW-MRI and DCE-MRI at 3-tesla for the noninvasive prediction of short-term radiation response for patients with localized prostate cancer.
Authors: Gilles Crehange, Philippe Maingon, Mélanie Gauthier, Alexandre Cochet, Etienne Martin, Céline Mirjolet-Didelot, Luc Cormier, Franck Bonnetain, Nicolas Vignon, Francois Brunotte, Paul M Walker
Journal: Journal of Clinical Oncology (2012)

122 Background: PSA is not appropriate for assessing early radiation response for patients treated with and without hormones for prostate cancer. New biomarkers using multiparametric functional MR could be of value. To investigate the benefits of multiparametric functional MR for predicting radiation response during the first year after radiation therapy in prostate cancer patients. Methods: Between 01/2008 and 04/2010, 34 patients with a localized prostate cancer (T1-T3, N0) were prospectively enrolled in the ERIS trial. All patients underwent high dose IMRT with or without long term adjuvant hormonal therapy and were prospectively followed with MR spectroscopy, diffusion-weighted MRI and dynamic contrast-enhanced MRI at 3-Tesla without endorectal coil every 3 months up to 1 year. Patients were followed with DRE, PSA level every 3 months and with sextant-biopsy at 6 and 12 months following radiation. Choline and Citrate levels on MRS, apparent diffusion coefficient on DW-MRI and the slope of the contrast uptake on DCE-MRI were measured in the central gland and in the peripheral zone every 3 months over 12 months and compared with PSA nadir at 12 months (≤0.5 ng/mL vs. &gt;0.5 ng/mL). Results: Cho, Cit and SCU significantly decreased over time whereas ADC remained stable. For the entire prostate at 3 months, the mean Cho level was higher in patients with PSA level &gt;0.5 ng/mL at 1 year (10.1±3.0 vs. 6.6±2.5, p= 0.004). Similarly, Cit level was higher at 3 months for patients with PSA level &gt; 0.5 ng/mL at 1 year (15.4±7.9 vs. 8.5±9.9, p= 0.0065). Neither ADC value nor contrast enhancement evaluated at each time interval was correlated with PSA at 1 year. Conclusions: Low Cho and Cit levels evaluated at 3 months are new markers for early success in prostate cancer patients treated with exclusive radiation therapy.
Il existe des biais de mesure de la taille des polypes par coloscopie, coloscanner et histologie liés à la préférence de chiffres terminaux
Authors: E. Coron
Journal: Endoscopy (2016)

La préférence de certains chiffres ou certains nombres “sacrés” a émaillé, de tous temps, l’histoire comme le montre par exemple le nombre accru de naissances en fonction du calendrier (tous les multiples de 0 ou 5 en Occident et tous les multiples de 12 en Chine). En médecine, il est bien démontré que cela induit des biais de mesure de pression artérielle, de poids de naissance ou de taille tumorale.