tbuckley/cabot-search huggingface dataset:
AB0306 The influence of the definition of patient global assessment in assessment of ACR/eular remission and minimal disease activity in rheumatoid arthritis: A 3-month cohort study in patients starting etanercept
Authors: M. Boers, Y. Brault, I. Logeart, M. Dougados
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The wording and form of the patient global assessment (PGA) question may influence the response and thus whether or not a patient meets the ACR/EULAR criteria for remission. <h3>Objectives</h3> To assess the effect of the definition of PGA on the classification of ACR/EULAR remission and minimal diseae activity in RA patients after starting etanercept. <h3>Methods</h3> We recently found a low impact of 3 different definitions of PGA on the evaluation of disease activity based on the DAS28 (Disease activity Score) in 108 active RA patients treated with etanercept for 12 weeks.[1] One definition focused on general health over the last 2-3 weeks, one on disease activity over the last 48 hours, and the final definition comprised the result of the RA Impact of Disease questionnaire (RAID), a weighted mean of 7 questions, one on each of the domains pain, function, fatigue, physical and psychological well being, sleep disturbance and coping. All were assessed on 0-10 numerical rating scales. The current analysis focuses on ACR/EULAR remission. We also studied the effects on patients with a DAS28 &lt;2.6. This was previously termed remission but is better defined as minimal disease activity.[2] <h3>Results</h3> Overall, depending on the chosen definition the number of patients in remission was between 9 and 12 (i.e., about 10%)for ACR/EULAR remission and about 26-27 patients (25%) for minimal disease activity. The definition of PGA had little impact on the cases classified in the Boolean or SDAI (Simple Disease Activity Index) definition, with 2-3 discrepant cases per comparison, and kappa coefficients ranging between 0.82 and 0.89. Keeping the PGA definition stable, the impact of using the Boolean or SDAI definition was larger: 4-6 discrepant cases, kappa 0.67-0.80. For minimal disease activity, there were 2-3 discrepant cases between PGA definitions (kappa 0.92-0.95). <h3>Conclusions</h3> In this dataset the definition of PGA had little impact on the classification of patients in ACR/EULAR remission or in minimal disease activity state. <h3>References</h3> Dougados M, Ripert M, Hilliquin P, et al. The influence of the definition of patient global assessment in assessment of Disease Activity According to the Disease Activity Score (DAS28) in rheumatoid arthritis. J Rheumatol 2011;38:2326-8. Wells GA, Boers M, Shea B, et al. Minimal disease activity for rheumatoid arthritis: a preliminary definition. J Rheumatol 2005;32:2016-24. <h3>Disclosure of Interest</h3> M. Boers: None Declared, Y. Brault Employee of: Pfizer SAS, France, I. Logeart Employee of: Pfizer SAS, France, M. Dougados Grant/Research support from: Pfizer SAS, France
FRI0546 Patient-Reported Joint Count in Juvenile Idiopathic Arthritis: the Reliability of A Mannequin Format
Authors: M. Dijkstra, J. Anink, P.A. van Pelt, J.M. Hazes, L.W. van Suijlekom-Smit
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is a chronic disease, that often requires regular monitoring. Patient-reported outcome measures (PROs) can be a useful tool to observe disease activity between clinic visits, increase the patient involvement and also to aid epidemiological surveys. One of these PROs is the self-reported joint count. The self-reported joint count in a mannequin format, in which the patient indicates which joints are inflamed on a figure, appeared more reliable in rheumatoid arthritis than the text format. It has not been tested before in JIA. <h3>Objectives</h3> The objective of this study was to evaluate the reliability of a patient-reported joint count in JIA in a mannequin format. <h3>Methods</h3> JIA patients aged 12-21 were asked to mark on a mannequin (see figure 1) the joints they felt to have active arthritis on a mannequin before their regular clinical visit. The physician then performed a formal joint count on the same day without having seen the patient9s assessment. Agreement between total scores of physician and patient-reported joint counts was assessed using Intraclass Correlation Coefficient (ICC). Kappa statistics were used to assess reliability of scoring of individual joints. <h3>Results</h3> 53 JIA patients (3 systemic, 12 persistent oligoarthritis, 4 extended oligoarthritis, 10 polyarthritis Rheumatoid Factor (RF) positive, 12 polyarthritis RF negative, 7 psoriatic arthritis, 4 enthesitis-related arthritis and 1 undifferentiated arthritis) participated in this study. In general patients had a low number of active joints (median 1 and 2 joints, as indicated by the physician and patient joint counts respectively). ICC was moderate (0.51) and kappas mostly ranged from 0.4-0.7. Taking the physician9s joint count as a reference, the predictive value of a patient scoring 0 active joints was 100%. When a patient did score a number of active joints, only in 76% the physician could also find signs and symptoms to confirm this. <h3>Conclusions</h3> The mannequin-format patient-reported joint count gives a reasonable estimate of the number of active joints according to the physician. Patients tend to overestimate the presence of arthritis. Therefore this self-reported joint count cannot fully replace the physicians9 joint count in JIA. It can however be used in epidemiological studies with caution. Further research needs to be performed to examine whether agreement can be improved by training and whether the mannequin joint count can be used to detect changes in disease activity over time. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3138
Novobiocin in the Treatment of Surgical Infections Due to Staphylococci and Other Gram-Positive Bacteria
Authors: A. M. Rutenburg, Paul Shapiro, Fritz Schweinburg, Elsie Sylvester, Mary Nakamura
Journal: New England Journal of Medicine (1956)

NOVOBIOCIN (Cathomycin) is a new antibiotic isolated from cultures of Streptomyces spheroides 1 and effective in vitro against a variety of gram-positive bacteria.2 , 3 Among the gram-positive micro-organisms the staphylococci are particularly sensitive to the action of this antibiotic. Of special interest is its reported efficacy against strains of staphylococci resistant to other antibiotics.The present report deals with the in vitro anti-microbial activity of novobiocin and its efficacy in the treatment of a variety of surgical infections due to staphylococci and other gram-positive bacteria largely resistant, in vitro and in patients, to other antibiotics. This series includes for the most part . . .
Diagnosis of a mucinous pancreatic cyst and resection of an intracystic nodule using a novel through-the-needle micro forceps
Authors: Khanh Pham, Trond Engjom, Hilde Gjelberg Kollesete, Lars Helgeland
Journal: Endoscopy (2016)

Pancreatic cystic lesions (PCLs) are detected in over 2 % of patients who undergo computed tomography (CT) and magnetic resonance imaging screening [1] [2]. Most PCLs are harmless, but some have the potential for malignant transformation. The management of PCLs is challenging, with high resource use. The standard option for the acquisition of cellular material from PCLs is endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA). Although many types of needles are available [3], it is usually not possible to obtain a reliable biopsy from the cyst wall for a more certain histological diagnosis. In four recently reported cases, a through-the-needle forceps was used to obtain biopsies from PCLs [4] [5] [6]. We report the first case in which a novel through-the-needle micro forceps (Moray, US Endoscopy, Ohio, USA) ([Fig. 1]) was used to diagnose a PCL, and to biopsy and resect an intracystic nodule.
THE IMPACT OF NEW SCREENING CRITERIA FOR CARDIAC FABRY DISEASE IN HYPERTROPHIC CARDIOMYOPATHY PATIENTS
Authors: Jiwon Seo, Minji Kim, Geu-Ru Hong, In-Jeong Cho, Chi Young Shim, Hyuk-Jae Chang, Jong-Won Ha, Namsik Chung
Journal: Journal of the American College of Cardiology (2015)
AB0883 The Factors Affecting the FAT Body Mass in Patients with Juvenile Idiopathic Arthritis
Authors: A. Hari, S. Rostom, R. Lahlou, D. Khnaba, R. Bahiri, N. Hajjaj-Hassouni
Journal: Annals of the Rheumatic Diseases (2014)

Objectives To determine the factors influencing the fat body mass in patients with juvenile idiopathic arthritis. Methods A cross sectional study in patients with juvenile idiopathic arthritis (JIA) according to the International League of Association of Rheumatology criteria was conducted. Sociodemographic parameters and clinical data related to the disease were collected. Fat body mass was measured by dual energy X-ray absorptiometry on Lunar Prodigy machine at the full body. Disease activity of the JIA was assessed by the number of painful joints (PJ), number of swollen joints (SJ), thevisual analogic scale (VAS) of painassessed by patient (VASp) and physician (VASd), and biological parameters (ESR,CRP). The daily food intake was assessed by a questionnaire for 7 consecutive days. Two nutritionists analyzed the diet to identify its macronutrient and oligonutriments content. Food intake was analyzed by Bilnut Version 2.01 software 1991. Results Thirty-three patients with JIA were included. The mean age was 10±4.35 years with a male predominance (54.5%). Twenty-four percent had a systemic subtype, 27% an oligoarticular and 48% a polyarticular subtype. The median disease duration was 2 years (1-4.5). The median duration of taking corticosteroids was 3 years (1-6). The median of fat mass, PJ, SJ, VASp, VAS d, ESR and CRP were respectively 4.97g (15.96-33.45), 3 (1-9), 1 (0-3), 20 (10-50) 35 (25-50.5) 20 (10.5-40).The median content of the feed proteins, lipids and carbohydrates was respectively1.7g (0-4.75), 0.8 g (0-11.65), and 11.1g (0-32.8). There were no correlation between fat mass and disease activity of JIA parameters: PJ (r=0.27, p=0.20), SJ (r=0.29, p=0.18), VASp (r=0.06, p=0.76), VAS d (r=0.13, p=0.53), ESR (r=0.18, p=0.4), CRP (r=0.24, p=0.28). There was a positive correlation between fat mass and the cumulative dose of corticosteroids (r=0.55, p=0.04) whereas there was no correlation with duration of its use (r=0.24, p=0.41). There were no correlation between the mass fat and the protein content of feed (r=0.13, p=0.54), fat content (r=0.15, p=0.5) and carbohydrates (r=0.07, p=0.73). Conclusions This study suggests that fat mass was not correlated with the activity of JIA or the content of macronutrients in the diet but it was associated with the cumulative dose of corticosteroids parameters. Disclosure of Interest None declared DOI 10.1136/annrheumdis-2014-eular.5276
The Effects of Pollen Season On Adverse Reactions to SCIT
Authors: Devi Jhaveri, Julie Abraham, Shiela Bigelow, Lyndsy Boggs, Megan Betteley, Mary Ann O'Riordan, David A. Swender, Leah W. Chernin, Theodore H. Sher, Robert W. Hostoffer, Haig Tcheurekdjian
Journal: Journal of Allergy and Clinical Immunology (2013)
Abstract 3675: Farnesyltransferase inhibitor (FTI) disruption of Rheb/FKBP38 association leads to FKBP38-mediated inactivation of mTOR
Authors: Hua Yang, De-An Wang, Andrew D. Hamilton, Said M. Sebti
Journal: Cancer Research (2010)

Abstract The activation of the Rheb (Ras homologue enriched in brain) / mTOR (mammalian target of rapamycin) pathway plays a central role in integrating growth factor, nutrient and energy signals and regulates cell growth (cell mass and size) and proliferation (cell number). Recently Rheb was found to activate mTOR by binding and antagonizing its endogenous inhibitor, FKBP38. However, it is not known whether inhibition of Rheb farnesylation by farnesyltransferase Inhibitors (FTIs) is sufficient to disrupt Rheb/FKBP38 interaction and leads to inactivation of mTOR. Here we demonstrate that FTI-2153 disrupts Rheb binding to FKBP38 allowing FKBP38 to bind and to inactivate mTOR. Furthermore, in human cancer cells, FTI-2153 also blocks IGF-1-stimulated Rheb/FKBP38 binding and promotes mTOR/FKBP38 binding. We further show that FTI-2153 inhibits Rheb-mediated activation of mTOR to phosphorylate S6 kinase, and that a geranylgeranylated mutant variant of Rheb that is as efficient as wild-type farnesylated Rheb at activating mTOR rescues cancer cells from FTI-induced inactivation of mTOR signaling, inhibition of anchorage-dependent and -independent tumor cell growth and induction of apoptosis. These results demonstrate that FTI-mediated disruption of the Rheb/FKBP38 interaction leads to inactivation of mTOR and is an effective approach to inhibiting tumor proliferation and survival and that inhibition of Rheb farnesylation mediates, at least in part, the anti-tumor effects of FTIs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3675.
Varicose Veins and Telangiectasias: Diagnosis and Treatment
Authors: A Marston
Journal: BMJ (1994)

Ed John Bergen, Mitchell P Goldman Quality Medical Publishing, pp 448 ISBN 0-942219-44-9

Snobbery is not confined to people; it applies to ideas as well. There is a sort of pecking order in disease processes, so that organ transplantation, separation of Siamese twins, and massive surgery for cancer are all among the aristocracy whereas chiropody and psychogeriatrics are not. Despite their frequency and social consequences, and the distress and discomfort they cause to a great number of people, venous disorders of the leg have until recently ranked very low indeed. At one famous hospital where I used to work the varicose vein clinic was by tradition given to the most junior …
Abstract 57: Adipocyte oxidative stress promotes epithelial-mesenchymal transition (EMT) related gene expression and estrogen receptor (ER) negative phenotype in breast cancer cells
Authors: Aiwei Yao-Borengasser, Behjatolah Monzavi-Karbassi, Rebecca A. Hedges, Thomas Kieber-Emmons, Susan A. Kadlubar
Journal: Cancer Research (2012)

Abstract Epidemiological studies have linked obesity with basal-like breast cancer risk in both premenopausal and postmenopausal women, suggesting that obesity may affect tumor phenotype by skewing the microenvironment toward support of more aggressive tumor cell phenotypes (typically ER/PR−, HER-2−). In order to study the interactions between adipocytes and breast tumor cells, we developed an adipocyte-breast cancer cell co-culture system. The adipocytes SGBS (Simpson-Golabi-Behmel Syndrome) and human ER positive breast cancer MCF7 cells were co-cultured for 24 hours. Following co-culture, the cells from the inserts (MCF7 cells) and wells (SGBS cells) were collected separately and total RNA was then isolated. The mRNA levels of the NADPH oxidase subunit NOX4 and hypoxia-inducible factor 1α (HIF1α) were determined by RT-PCR and normalized to 18S RNA levels. When SGBS cells were co-cultured with MCF7 cells, SGBS NOX4 and HIF1α mRNA levels increased more than 10 fold and 3 fold, respectively, while there were no changes in NOX4 and HIF1α expression detected in co-cultured MCF7 cells. We also compared several epithelial-mesenchymal transition (EMT) process-related gene expression levels. Expression in MCF7 cells of the EMT-inducing transcription factors FOXC2 and Twist1 were increased more than 8 fold and 5 fold respectively, after co-culture with SGBS. E-cadherin mRNA level was decreased 2 fold, while N-cadherin mRNA level was increased more than 6 fold in co-cultured MCF7. We also found that mRNA levels of ER-α were significantly (p&amp;lt;0.05) repressed in MCF7 cells co-cultured with SGBS cells. To explore the mechanism of the effect of adipocyte co-culture on ER expression in breast cancer cells, SGBS cells were transfected with 30nM of siHIF1α for 48 hours before co-culture with MCF7 cells. ER gene expression level did not change in MCF7 cells co-cultured with SGBS cells that had been transfected with siHIF1α. In summary, we have shown that adipocytes and breast tumor cells interact with each other: MCF7 cells increased hypoxia and oxidative stress in SGBS cells, while SGBS increased the expression of EMT-inducing factor genes in MCF7 cells, as well as repressing ER expression. This repression was controlled, at least in part, by HIF1α. These results suggest that hypoxia and oxidative stress from adipocytes can modify ER gene expression and promote EMT processes in breast cancer cells, supporting an important role of obesity in aggressive breast cancer development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 57. doi:1538-7445.AM2012-57
Abstract 5406: Glioblastoma derived exosomes induce apoptosis in T cells
Authors: Keith Z. Sabin, Robert J. Winn
Journal: Cancer Research (2012)

Abstract Intro: Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults and is associated with an average lifespan of 15 months after diagnosis. One contributing factor to this poor prognosis is the immune protection afforded by the tumor microenvironment. One method of immune evasion poorly characterized is the effect of tumor released exosomes. Methods: FasL gene expression was determined using reverse transcription polymerase chain reaction (RT-PCR) in three GBM cells lines: LN-229, U-138 MG and T98G. Exosomes were isolated from serum free supernatants by differential ultracentrifugation. Exosomes were quantified using a protein concentration assay. A3 Jurkat T cells were treated with quantified exosomes, recombinant FasL or untreated. After 24 hours a TUNEL assay was performed to investigate the potential apoptotic effects of GBM-derived exosomes. Results: FasL is expressed in LN-229, U-138 MG and T98G cell lines as determined by RT-PCR. After treating A3 Jurkat T cells with exosomes it appeared apoptosis was induced as compared to an untreated control as determined by DNA fragmentation. Discussion: Studies using prostate and colon cancer cell lines showed that FasL was expressed in tumor derived exosomes. When T cells were co-cultured with exosomes apoptosis was induced in a FasL-dependant manner. Our lab previously demonstrated that GBM-derived exosomes are able to inhibit T cell proliferation. These current data suggests that GBM-derived exosomes induce apoptosis in T cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5406. doi:1538-7445.AM2012-5406
Abstract 984: The role of branched-chain amino acids (BCAAs) oxidation in the survival of brain metastatic breast cancer cells
Authors: Xuefeng Wu, Zhang Weihua
Journal: Cancer Research (2011)

Abstract Background: Glucose is the main source of energy for most cells. When the glucose is limited some cells can use amino acids to support their survival. This ability of oxidizing branched chain amino acids (BCAAs) of the brain metastatic breast cancer cells was investigated. Methods: Breast cancer cell lines, MDA-MB-231 cell and its brain metastatic derivative MDA-MB-Br3 were used in this study. The survivability, ability of oxidizing BCAAs and expression of BCAA oxidation related enzymes of these cells were determined. Results: MDA-MB-Br3 cells survived well and oxidized more BCAAs than MDA-MB-231 cells when cultured in glucose free medium. Accordingly, the activity of branched-chain a-ketoacid dehydrogenase complex of MDA-MB-Br3 cells is significantly higher than that of the MDA-MB-231 cells. Conclusions: The breast cancer cell line MDA-MB-Br3 can use BCAAs as a resource of energy for survival in the environment with very low level of glucose. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 984. doi:10.1158/1538-7445.AM2011-984
Modulation of atrioventricular conduction by isometric exercise in human subjects.
Authors: A Ferrari, O Bonazzi, M Gardumi, L Gregorini, R Perondi, G Mancia
Journal: Circulation Research (1981)

In humans, arterial baroreceptow depress atrioventricular (AV) conduction through vagal influences on the AV node but not on the His-Purkinje fibers.We investigated the influence on AV conduction of an excitatory neural influence, i.e., isometric exercise (handgrip).In subjects with normal AV conduction, blood pressure was measured by an intra-arterial catheter, R-R interval by an electrocardiogram, and A-H and H-V intervals (representing conduction, respectively, through the AV node and the His-Purkinje fibers) by His bundle recording.Handgrip raised blood pressure markedly, it shortened R-R interval, and caused no change in A-H and H-V intervals.Because prior studies had demonstrated that autonomic influences over AV conduction can be quantified accurately only when heart rate is constant, the subjects also were studied during atrial pacing.Under this condition, handgrip again caused a marked pressor response but also induced a marked shortening in the A-H interval (30%) whereas the H-V interval still wax unaffected.The handgrip-induced shortening in the A-H Interval was less pronounced after atropine but it was also Impaired by propranolol.Thus AV conduction normally is modulated by inhibitory influences but also by powerful excitatory stimuli.Like the inhibitory influences, the excitatory ones are seen mainly at constant heart rate and are limited to the AV node with no effect on the His-Purkinje fibers.Unlike the Inhibitory Influences, however, the excitatory modulation is substantially mediated via the cardiac sympathetic nerves.
Indian government promises paediatric formulations of TB drugs
Authors: M. Chaudhuri
Journal: BMJ (2012)

The Indian government has approved a new protocol for treating paediatric tuberculosis and has said that it would procure specially formulated drugs suitable for children.

Ashok Kumar, deputy director general for tuberculosis at the Ministry of Health and Family Welfare, said that a consultation was held to revise the protocols for treatment of tuberculosis in children eight years ago but that the decision to revise the guidelines was taken only this year.

Kumar said that the new protocol had increased the number of weight bands from four to six …