tbuckley/cabot-search huggingface dataset:
Incidence of Neoplasms and Other Late Lesions in Mice Protected against Lethal X-Ray Doses by Spleen Homogenate&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn2"&gt;3&lt;/xref&gt;
Authors: L J COLE, M E ELLIS, P C NOWELL
Journal: JNCI Journal of the National Cancer Institute (1956)

Incidence of Neoplasms and Other Late Lesions in Mice Protected against Lethal X-Ray Doses by Spleen Homogenate, Get access Leonard J. Cole, Leonard J. Cole Biological and Medical Division, U. S. Naval Radiological Defense Laboratory, San Francisco, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Peter C. Nowell, Peter C. Nowell Biological and Medical Division, U. S. Naval Radiological Defense Laboratory, San Francisco, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Marie E. Ellis Marie E. Ellis Biological and Medical Division, U. S. Naval Radiological Defense Laboratory, San Francisco, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 4, October 1956, Pages 435–445, https://doi.org/10.1093/jnci/17.4.435 Published: 01 October 1956 Article history Received: 08 May 1956 Published: 01 October 1956
LG-28THREAT TO VISION SCORE (TTV SCORE) IN CHILDREN WITH OPTIC PATHWAY GLIOMAS (OPGS): UK EXPERIENCE FROM PROSPECTIVE LOW GRADE GLIOMA (LGG2) TRIAL
Authors: Evangelos Drimtzias, Susan Picton, David Richards, Kevin Falzon, Janice Hoole, Ian Simmons
Journal: Neuro-Oncology (2016)
Pigmentation in African American skin decreases with skin aging
Authors: Anna L. Chien, Jean Suh, Sabrina Sisto Alessi Cesar, Alexander H. Fischer, Nancy Cheng, Flora Poon, Barbara Rainer, Sherry Leung, Jo Martin, Ginette A. Okoye, Sewon Kang
Journal: Journal of the American Academy of Dermatology (2016)
An Extra 1,000 Steps Per Day Relates to Improved Cardiovascular Health in Children With Type 1 Diabetes
Authors: Jemma Anderson, Jennifer J. Couper, Christine Mpundu-Kaambwa, Lynne C. Giles, Roger Gent, Brian Coppin, Alexia S. Peña
Journal: Diabetes Care (2016)

Children with type 1 diabetes report lower physical activity levels than those given in the current recommendations (1), and the effect of this on vascular health, measured objectively, is not well described. Children with type 1 diabetes have vascular structural changes (increased carotid and aortic intima-media thickness [cIMT and aIMT, respectively]) (2,3). aIMT relates to cIMT and both relate to cardiovascular risk factors. aIMT has been shown to be an earlier marker of atherosclerosis in children (2,3). We aimed to determine the relationship between activity levels and IMT in children with type 1 diabetes. We hypothesized that lower activity levels would relate to thicker IMT.

The study included 90 children with type 1 diabetes (41 boys, aged 13.6 ± 3.5 years) and was approved by ethics committees (4). Children had evaluation of cIMT and aIMT as previously …
GC-11PRELIMINARY RESULTS OF A CNSGCT BRAZILIAN PROTOCOL CONSORTIUM
Authors: Andrea M. Cappellano, Bruna Mançano, Daniela Barbosa, Sergio Cavalheiro, Patricia A. D'astoli, Frederico A. Silva, Simone S. Aguiar, Elvis Valera, Nasjla S. da Silva
Journal: Neuro-Oncology (2016)
Management of viral haemorrhagic fever in the Netherlands
Authors: C Swaan, P- J. van den Broek, S Wijnands, J. E. van Steenbergen
Journal: Eurosurveillance (2002)

Two cases of Lassa fever have been reported in the Netherlands since viral haemorrhagic fevers became notifiable diseases in 1978. In 1980, an expatriate from Burkina Faso who was not seriously ill was confirmed by laboratory tests after his discharge from hospital. The second case occurred in 2000: the patient died on the 11th day of admission to hospital. The problems we faced in the management of this case and the contact investigation--more than one hundred contacts - highlighted the need for national recommendations in the Netherlands.
NU-02PALLIATIVE CARE FOR PAEDIATRIC PATIENTS WITH BRAIN TUMOURS: IT'S NOT ALL ABOUT THE MORPHINE
Authors: Suzanne Momber
Journal: Neuro-Oncology (2016)

Palliative care refers to the supportive care and symptom management required to help children with life-limiting illnesses to live as well as they can for as long as they can.Though families are concerned about alleviating their child's pain, deterioration in function is often more significant to overall quality of life.Although research and technology continue to Overall survival
Non-Acquired Immune Deficiency Syndrome-Defining Malignancies in a Hospital-Based Cohort of Human Immunodeficiency Virus-Infected Patients: Bordeaux, France, 1985-1991
Authors: M. Hajjar, D. Lacoste, G. Brossard, P. Morlat, M. Dupon, L. R. Salmi, F. Dabis
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Non-Acquired Immune Deficiency Syndrome-Defining Malignancies in a Hospital-Based Cohort of Human Immunodeficiency Virus-Infected Patients: Bordeaux, France, 1985–1991 Get access Moufid Hajjar, Moufid Hajjar * Université de Bordeaux 2France *Correspondence to : Moufid Hajjar, M.D., INSERM U330, Département d'Informatique Médicale, Université de Bordeaux 2, 146, Rue Léo-Saignat, 33076 Bordeaux Cedex, France. Search for other works by this author on: Oxford Academic PubMed Google Scholar Denis Lacoste, Denis Lacoste Centre Hospitalier Régional Universitaire de Bordeaux 2, Université de Bordeaux Search for other works by this author on: Oxford Academic PubMed Google Scholar Gilles Brossard, Gilles Brossard Centre Hospitalier Régional Universitaire de Bordeaux 2, Université de Bordeaux Search for other works by this author on: Oxford Academic PubMed Google Scholar Philippe Morlat, Philippe Morlat Centre Hospitalier Régional Universitaire de Bordeaux 2, Université de Bordeaux Search for other works by this author on: Oxford Academic PubMed Google Scholar Michel Dupon, Michel Dupon Centre Hospitalier Régional Universitaire de Bordeaux 2, Université de Bordeaux Search for other works by this author on: Oxford Academic PubMed Google Scholar L. Rachid Salmi, L. Rachid Salmi Université de Bordeaux 2France Search for other works by this author on: Oxford Academic PubMed Google Scholar François Dabis, François Dabis Université de Bordeaux 2France Search for other works by this author on: Oxford Academic PubMed Google Scholar Groupe d'Epidémiologie Clinique du SIDA en Aquitaine Groupe d'Epidémiologie Clinique du SIDA en Aquitaine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 20, 21 October 1992, Pages 1593–1595, https://doi.org/10.1093/jnci/84.20.1593 Published: 21 October 1992 Article history Received: 02 March 1992 Revision received: 04 August 1992 Accepted: 12 August 1992 Published: 21 October 1992
Relationships between genetic polymorphisms and anticancer drug cytotoxicity vis-à-vis the NCI60 panel
Authors: Valerie Lemorvan, Ricardo Bellott, François Moisan, Simone Mathoulin-Pelissier, Jacques Bonnet, Jacques Robert
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

1317 

The NCI60 panel consists of 60 human tumor cell lines which were initially used for the screening of thousands of molecules for their potential anticancer activity, with a disease-oriented strategy. This panel has been especially powerful for deciphering the relationships between the cytotoxicity of anticancer agents and the molecular characteristics of the cell lines. We have tested the potential interest of the panel in order to establish relationships between the polymorphism of genes involved in metabolism and transport of anticancer agents or in DNA repair, and the cytotoxicity of these agents as indicated in the NCI databases. Using a PCR-RFLP technique, three frequent single nucleotide polymorphisms (SNP) were analyzed in order to validate this approach: the Lys751Gln SNP of the Xeroderma pigmentosum complementation group D (XPD) gene, the Asp1104His SNP of the Xeroderma pigmentosum complementation group G (XPG) gene and the Ile105Val SNP of the glutathione S-transferase P1 (GSTP1) gene. The allelic frequencies of the variants were 33% for XPD, 23% for XPG and 39% for GSTP1. The XPD polymorphism appeared as a strong determinant of the in vitro cytotoxicity of most anticancer agents, which have systematically lower IC50 values in variant homozygous lines than in common homozygous or heterozygous cell lines. Unexpectedly, the cytotoxicity of spindle poisons appeared especially dependent upon the XPD genotype, with three-fold lower mean IC50 values in variant homozygous cell lines ( P =10-8). The XPG genotype appeared important only for the taxanes, with nearly four-fold higher IC50 values in variant homozygous cell lines ( P =10-6). The GSTP1 polymorphism was related to the cytotoxicity of several drug classes, especially topoisomerase I and II inhibitors and N7 alkylating agents; the mean IC50 values of these compounds was 1.4 to 2.2 times lower in variant homozygous cell lines than in common homozygous cell lines. The NCI60 panel appears as capable of providing clues and tracks for the establishment of clinically useful relationships between a given genotype and the cytotoxicity of an anticancer agent.
Membranous Nephropathy
Authors: H A Austin, T T Antonovych, K MacKay, D T Boumpas, J E Balow
Journal: Annals of Internal Medicine (1992)

Membranous nephropathy is a worldwide problem that accounts for about 20% of the cases of the adult-onset nephrotic syndrome. This disease places many patients at risk for both end-stage renal failure and the complications of hyperlipidemia. Immunemediated injury to the glomerular capillary wall in patients with membranous nephropathy is characterized by subepithelial immune complex formation and generation of the membrane attack complex of complement. Glomerular capillary hypertension, hyperlipidemia, and possibly cytokines could contribute to the glomerular sclerosis seen in the advanced stages of the disorder. In some cases, production of pathogenic antibody can be suppressed by treating the underlying condition. The mechanisms of action of immunosuppressive agents are being investigated and treatments are being tested in clinical trials to optimize the balance of efficacy and toxicity. Alternate-day treatment with corticosteroids is often recommended for nephrotic patients with idiopathic membranous nephropathy, but this approach has not been proved beneficial. Ongoing studies are evaluating whether cytotoxic drugs or cyclosporin A combined with prednisone is more effective than treatment with corticosteroids alone. Lipid-lowering drug therapy is warranted in cases of the persistent nephrotic syndrome to avert the cardiovascular sequelae of hyperlipidemia.
Effect of Cigarette Smoke and Its Constituents on Ciliated Mucus-Secreting Epithelium&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Hans L. Falk, Ph.D., Herta M. Tremer, Ph.D., Paul Kotin, M.D.
Journal: JNCI Journal of the National Cancer Institute (1959)

One of the properties of cigarette smoke is its ability to interfere with the normal function of ciliated, mucus-secreting epithelium. The effect is manifested primarily by a slowing of the rate of mucous flow, quantitative changes in mucous secretion, and qualitative changes in mucous consistency. The effect of cigarette smoke is dependent upon its aerosol nature as well as its chemical composition. Reduction in the quantity of aerosols in cigarette smoke results in a reduction in the intensity of the response of the epithelium. At all levels of aerosol production, however, a response is elicited. Filtration of smoke is capable of obviating the response only when it is sufficiently efficient to retain all particulate matter so that gas-phase material alone results. This gas phase, in the concentrations studied, produces no significant effect on the epithelium. It is well to emphasize that during this state the term “smoke” is not applicable. A study of the individual components in cigarette smoke demonstrates that both alkaloids and other chemical compounds are effective in producing the response. The application of an aqueous solution of tars, which were collected from filters, results in the inhibition of mucous flow typically seen with whole cigarette smoke. The accumulation and retention of particulate matter deposited on the epithelium is facilitated by the demonstrated adverse effect of cigarette smoke on the epithelium. This observation suggests a role for cigarette smoking in the pathogenesis of pulmonary cancer.
A Chemical Basis for Tumor-Host Relations
Authors: Waro Nakahara
Journal: JNCI Journal of the National Cancer Institute (1960)

Recent work on toxohormone, with emphasis on studies performed in Japan, is reviewed. These studies lend additional support to the concept that systemic effects in the tumor-bearing host involve the alteration of the enzyme level of normal tissue toward the direction of that of tumor tissue (Second Greenstein Law). Alterations of properties in the tumor-bearing host other than enzyme activities, such as involution of the thymus and decrease in liver ferritin, plasma iron, and diphosphopyridine-nucleotide synthesis, have been produced, in recent investigations, by the administration of toxohormone. These studies provide a chemical basis for further study of the effects of tumors on the host.
Abstract 15705: Chronic Inhaled Acrolein Depresses Circulating Endothelial Progenitor Cells and Promotes Atherosclerosis
Authors: Daniel J Conklin, Abhinav Agarwal, Srinivas Sithu, Iris Zeller, Petra Haberzettl, Timothy E O'Toole, Aruni Bhatnagar, Sanjay Srivastava
Journal: Circulation (2015)

We have previously shown that acute exposure to air pollutants including particulate matter or the volatile acrolein leads to reversible suppression of circulating angiogenic cells in humans and mice. Exposure to tobacco smoke, which contains both particles and aldehydes such as acrolein, also suppresses EPC number and function in association with an increase in cardiovascular disease risk. To assess whether acrolein alone worsened vascular pathogenesis, we exposed mice to acrolein (1 ppm * 6h/day) in a murine model of hind limb ischemia. Mice were exposed to acrolein for 4 days prior to permanent right femoral artery and vein ligation and bisection (distal to inguinal ligament) with continued exposure to filtered air (control) or acrolein for another 2 weeks. Blood flow recovery in the ischemic hind limb was measured via Laser Doppler Perfusion Imaging (LDPI) and normalized as a percentage of flow in the non-ischemic limb. Although acute exposure to acrolein reduced the number of circulating angiogenic cells it had only a modest effect blood flow recovery after 7 days (% Recovery: air, 86.2±21.4; acrolein, 68.3±21.6, n=8,8, p=0.12). Hence to determine whether chronic acrolein exposure worsened chronic vascular injury, we exposed C57BL/6J mice to 1 ppm acrolein for 12 weeks. This long-term exposure significantly depressed (by 51%) circulating levels of Flk-1+/Sca-1+ cells (as % of lymphocytic counts: air 0.15±0.09; acrolein 0.07±0.05; p&lt;0.02). To tested if cell changes were associated with changes in atherogenesis, apoE-null mice on normal chow or high-fat diet were exposed to chronic acrolein (1 ppm; 12 week). Acrolein accelerated aortic atherosclerosis by 1.6-fold (p&lt;0.001) but it did not affect coincident dyslipidemia (total cholesterol: air, 1224±189; acrolein, 1076±195 mg/dL) compared with air-exposed, HFD-fed mice. These results suggest that that chronic low level acrolein exposure suppresses circulating angiogenic cells and accelerates atherogenesis; hence the atherogenic effect of exposure to traffic pollutants, indoor smoke or cigarette smoke may be in part attributable to acrolein. These findings could inform exposure risk assessments and the development of new policies for regulating pollutant exposure and tobacco product use.
HG-28SURVIVAL BENEFIT FOR PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) UNDERGOING RE-IRRADIATION AT FIRST PROGRESSION: ANALYSIS OF THE SIOP-E-DIPG/HGG WORKING GROUP
Authors: Geert O. Janssens, Lorenza Gandola, Stephanie Bolle, Henry Mandeville, Monica Ramos-Albiac, Johan Menten, Helen Benghiat, Bianca Hoeben, Andres Morales La Madrid, Emilia Pecori, Max Peters, Rolf-Dieter Kortmann, Darren Hargrave, Andre O. von Bueren, Maura Massimino, Dannis G. van Vuurden, Christof M. Kramm
Journal: Neuro-Oncology (2016)
Salmonellosis outbreak due to Salmonella Enteritidis phage type 14b resistant to nalidixic acid, Austria, September 2010
Authors: L Hrivniaková, D Schmid, A Luckner-Hornischer, H Lassnig, C. Kornschober, J Angermayer, F Allerberger
Journal: Eurosurveillance (2011)

Binary file ES_Abstracts_Final_ECDC.txt matches
Chemohormonal therapy for older women with node-positive breast cancer.
Authors: M Brower, S N Rosenthal
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.11.1922 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2230880 Chemohormonal therapy for older women with node-positive breast cancer. M BrowerxM BrowerSearch for articles by this author , S N RosenthalxS N RosenthalSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.11.1922 PDF "Chemohormonal therapy for older women with node-positive breast cancer.." Journal of Clinical Oncology, 8(11), pp. 1922–1923© 1990 by American Society of Clinical Oncology
PTU-306 The efficacy of mrcp in suspected gallstone disease when the biliary tree is normal on previous imaging: Abstract PTU-306 Table 1
Authors: J Graby, A Goldman, M McPhail, B Vadwhana, M Lewis, C Ramsey, K Monahan
Journal: Gut (2015)

<h3>Introduction</h3> Magnetic Resonance Cholangiopancreatography (MRCP) is increasingly used in the diagnosis of biliary abnormalities, particularly in stone disease.<sup>1</sup>However initial studies into its role in the absence of a dilated biliary system on initial imaging have demonstrated a low diagnostic yield.<sup>2</sup>The aim of this study was to further assess the role of MRCP when the biliary tree is non-dilated on index imaging. The factors associated with diagnostic yield in this setting are unclear. <h3>Method</h3> We performed a retrospective observational study of consecutive MRCP studies (n = 375) performed between October 2010 and June 2013 at West Middlesex University Hospital using electronic medical records. All MRCPs were reported by a consultant gastrointestinal radiologist. MRCP findings were correlated with the presence of dilated or non-dilated biliary tree on initial imaging (USS/CT), jaundice (bilirubin &gt; 21 μmol/L), transaminitis (alanine transaminase &gt;45 iu/L, aspartate transaminase &gt;34 iu/L), raised alkaline phosphatase (&gt;120 iu/L) and abdominal pain, and demographics including age and gender. Multivariate logistic regression analysis was performed using SPSS software. <h3>Results</h3> The study included 243 female and 132 male patients with a mean age of 62 (range 20–101) years. There were 153 patients with biochemical jaundice, 246 with a dilated biliary system and 129 with a non-dilated system. The sensitivity of MRCP was 81%, with a specificity of 80%. Multivariate analysis identified that age (p = 0.0253), the presence of jaundice (p = 0.0247), and abnormal index imaging (p = 0.0003), are statistically significant predictors of the finding of biliary tree abnormalities on subsequent MRCP (see attached Table 1). The c statistic for the multivariate analysis was only moderately high at 0.665 (95% CI 0.614–0.712, p &lt; 0.001). <h3>Conclusion</h3> These data confirm there is a low diagnostic yield of MRCP in the absence of dilated biliary system on previous USS/CT. We propose that there should be a specific rationale for performing MRCP when initial imaging is normal, especially when the bilirubin is normal. Other clinical indices such as pain or abnormal liver chemistry (other than hyper-bilirubinaemia) are not independently predictive of positive finding on MRCP in our analysis. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Shanmugam V, <i>et al</i>. Is magnetic resonance cholangiopancreatography the new gold standard in biliary imaging? <i>Br J Radiol</i>. 2005;78:888–893 Vadwhana B, <i>et al</i>. Is MRCP a useful investigation where the biliary tree is normal on previous imaging? Gut 2013;<b>62</b>(Suppl 1):A210
Effects of the Order of Administration of Total Body Irradiation and Cyclophosphamide on the Outcome of Allogeneic Hematopoietic Cell Transplantation
Authors: Kenji Motohashi, Shin Fujisawa, Makoto Onizuka, Shinichi Kako, Emiko Sakaida, Katsumichi Shono, Raine Tatara, Noriko Doki, Takehiko Mori, Toru Sakura, Nobuyuki Aotsuka, Eriko Ogusa, Naoto Tomita, Nobutaka Kawai, Takayuki Saitoh, Kensuke Usuki, Jun Taguchi, Heiwa Kanamori, Satoshi Takahashi, Shinichiro Okamoto
Journal: Blood (2014)
Differences in brain serotonergic metabolism between nonbulimic and bulimic patients with anorexia nervosa
Authors: W H Kaye, M H Ebert, H E Gwirtsman, S R Weiss
Journal: American Journal of Psychiatry (1984)

CSF concentrations of serotonin and dopamine metabolites in 16 patients with anorexia nervosa were measured before and after probenecid administration, and the patients were studied before and at intervals after weight recovery. After probenecid administration, the weight-recovered nonbulimic anorexic patients had a higher concentration of the serotonin metabolite, 5-hydroxyindoleacetic acid, than the weight-recovered bulimic patients but no significant differences in CSF homovanillic acid. This finding is consistent with evidence that suggests a role for brain serotonin metabolism in carbohydrate and mood regulation.
The Catheptic Activities of the Tumors and Tissues of Tumor-Bearing Rats
Authors: Mary E. Maver, Thelma B. Dunn, Antoinette Greco
Journal: JNCI Journal of the National Cancer Institute (1948)

The Catheptic Activities of the Tumors and Tissues of Tumor-Bearing Rats Get access Mary E. Maver, Mary E. Maver senior biochemist Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn, Thelma B. Dunn pathologist Search for other works by this author on: Oxford Academic PubMed Google Scholar Antoinette Greco Antoinette Greco junior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 1, August 1948, Pages 39–41, https://doi.org/10.1093/jnci/9.1.39 Published: 01 August 1948 Article history Received: 05 May 1948 Published: 01 August 1948
GC-18A CASE FOR RAPID COMMENCEMENT OF RADIOTHERAPY FOR GERMINOMAS WITH SECONDARY MASS EFFECT AND HYDROCEFALUS
Authors: Erik Edström, Ulrika Sandvik, Pernilla Grillner, Stefan Holm, Gun Wickart, Bengt Gustavsson
Journal: Neuro-Oncology (2016)

A previously healthy seven years old girl presented with a two week history of headache and vomiting.Symptoms also included increased thirst, enuresis, diminished appetite and constipation.A CT-scan revealed a large centrally located intracranial mass and secondary hydrocephalus.Subsequent MRI Overall survival
Development and Validation of a Risk Scoring System for Severe Acute Lower Gastrointestinal Bleeding
Authors: Tomonori Aoki, Naoyoshi Nagata, Takuro Shimbo, Ryota Niikura, Toshiyuki Sakurai, Shiori Moriyasu, Hidetaka Okubo, Katsunori Sekine, Kazuhiro Watanabe, Chizu Yokoi, Mikio Yanase, Junichi Akiyama, Masashi Mizokami, Naomi Uemura
Journal: Clinical Gastroenterology and Hepatology (2016)