tbuckley/cabot-search huggingface dataset:
FRI0089 Utility of a Novel Inflammatory Marker, Glyca, for Assessment of Rheumatoid Arthritis Disease Activity and Coronary Atherosclerosis
Authors: M. Ormseth, C. Chung, A. Oeser, M. Connelly, T. Sokka, P. Raggi, J. Solus, J. Otvos, C.M. Stein
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> GlycA is a novel inflammatory biomarker measured using nuclear magnetic resonance (NMR). Its NMR signal primarily represents glycosylated acute phase proteins. GlycA is associated with inflammation and development of cardiovascular disease in initially healthy women. We hypothesized that GlycA is a biomarker of disease activity and is associated with coronary artery atherosclerosis in patients with rheumatoid arthritis (RA). <h3>Methods</h3> We conducted a cross-sectional study of 166 patients with RA and 90 control subjects. GlycA was measured from an NMR signal originating from N-acetylglucosamine residues on circulating glycoproteins. The relationship between GlycA and RA disease activity (DAS28 score) and coronary artery calcium score was determined. <h3>Results</h3> GlycA concentrations were higher in patients with RA (median [interquartile range]: 398 μmol/L [348, 473 μmol/L]) than control subjects (344 μmol/L [314, 403 μmol/L], P&lt;0.001). In RA, GlycA was strongly correlated with DAS28-ESR and DAS28-CRP and their components including tender and swollen joint count, global health score, ESR and CRP (All P&lt;0.001). The area under the receiver operating characteristic curve for GlycA9s ability to differentiate between patients with low versus moderate-to-high disease activity based on DAS28-CRP was 0.75 (95% CI: 0.68, 0.83). For each quartile increase in GlycA, odds of having coronary artery calcium increased by 48% (95% CI: 4%, 111%), independent of age, race and sex (P=0.03). <h3>Conclusions</h3> GlycA is a novel inflammatory marker that may be useful for assessment of disease activity and is associated with coronary artery atherosclerosis in patients with RA. <h3>Disclosure of Interest</h3> M. Ormseth: None declared, C. Chung: None declared, A. Oeser: None declared, M. Connelly Employee of: LabCorp, T. Sokka: None declared, P. Raggi: None declared, J. Solus: None declared, J. Otvos Employee of: LabCorp, C. M. Stein: None declared
SAT0498 MBL2 and the FCN2 Polymorphisms in a Group of Pediatric Subjects with Rheumatic Fever: A Case Control Study (Preliminary Data)
Authors: C. Di Battista, V. Marzetti, L. Stuppia, R. Ferrante, M. Lucantoni, M. Marsili, L. Breda, F. Chiarelli
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Human ficolins (FCN) and mannan-binding lectin (MBL2) are pattern-recognition proteins involved in innate immunity. It has been suggested a role for MBL2 and FCN2 gene polymorphisms in the pathogenesis of recurrent, severe streptococcal infections and rheumatic carditis. <h3>Objectives</h3> The aim of this study is to evaluate the presence of MBL2 and FCN2 gene polymorphisms (SNPs) in children with a history of acute rheumatic fever (ARF) and to investigate their possible role in ARF clinical presentation and disease course. <h3>Methods</h3> 29 Caucasian patients with ARF were recruited with a control group of 24 healthy children. DNA was extracted for analysis of MBL2 gene (exon 1, codons: 52, 54 and 57) and FCN2 (promoter at position -4, -986 and -602). <h3>Results</h3> We found no different distribution of the analyzed MBL2 genotypes between patients and controls. Besides, no significant association between MBL2 SNPs and ARF clinical manifestations has been demonstrated. We observed that the FCN2 GGA haplotype (particularly the G polymorphism at position -986) seems to be significantly more represented in the control group (G in -986 6,9% vs 41,7% patients vs controls, p=0,003).The FCN2 G polymorphism at position -986 (0% vs 41.7% carditis vs controls, p=0,03) is also significantly less represented in children with carditis. The FCN2 G polymorphism at position -4 (11,1% vs 50% arthritis vs controls, p=0,04) is significantly less represented in children with arthritis. <h3>Conclusions</h3> The FCN2 GGA haplotype (especially the G polymorphism at position -986) might be considered a protective factor for ARF development. In particular, the FCN2 G polymorphism at position -986 seems to have a protective role for the development of rheumatic carditis and the FCN2 G polymorphism at position -4 seems to represent a protective factor for the development of arthritis. Further studies including larger populations and evaluating circulating FCN2 protein are needed to confirm these data. <h3>References</h3> Schafranski MD, Pereira Ferrari L, Scherner D, Torres R, Jensenius JC, De Messias-Reason IJ. High-producing MBL2 genotypes increase the risk of acute and chronic carditis in patients with history of rheumatic fever. Mol Immunol 2008.45:3827-31. Messias Reason IJ, Schafranski MD, Kremsner PG and Kun JFJ. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. Clin and Exp Immunol 2009.157:395-399. <h3>Disclosure of Interest</h3> None declared
PTU-178 The clinical effectiveness of a low fodmap dietary approach in clients with functional gut disorder
Authors: C Mccamphill, G Morrison
Journal: Gut (2015)

<h3>Introduction</h3> To assess the clinical effectiveness of a Low FODMAP diet in clients referred with functional gut disorder. <h3>Method</h3> Funding was sought to set up a Low FODMAP pilot clinic, 3.5 h per week for six months. A local protocol and care pathway was developed by the author. Potential clients were referred by the Consultant Gastroenterologist. An audit template developed and completed. <h3>Results</h3> 19 Clients where recruited to the pilot phase. There was an overall 88% adherence to the three appointment care pathway. There was reduced use of antispasmodics, anti-diarrhoeals and laxatives from appointment one to appointment three. 56.3% of clients had the symptoms &gt;10 years, with 100% having the symptoms more than 1 year. Thus it is very important to build a good rapport and relationship with the client from the start. The author does feel that the carepathway designed, of 3 appointments with 1 h long sessions, is essential in building this relationship. As IBS is known to be a relapsing condition it is important that all education is given accurately to prevent the client from re-entering the healthcare system at a later date. 64% of clients reported following the diet &gt;75% of the time. 67% of clients reported having overall satisfactory relief of gut symptoms at appointment two, with 71% reporting overall satisfactory relief of gut symptoms at appointment three. The individual patient satisfaction questionnaire results at the 3<sup>rd</sup>appointment exhibited: 85% improved in bloating, 78% improved in abdominal/discomfort, 77% flatulence/wind improvement, 69% diarrhoea improvement, 46% improvement in constipation, 46% improvement in nausea and 62% improvement in energy. Only 13% of clients were re-referred back to the Consultant Gastroenterologist. <h3>Conclusion</h3> Overall, 88% of clients completed the carepathway within the designated time. Only 13% were re-referred back to the Consultant Gastroenterologist for further investigation/treatment options. 71% of clients who completed the carepathway reported overall satisfactory relief of gut symptoms. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Staudacher HM, Whelan K, Irving PM, Lomer MCE. Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with Irritable Bowel Syndrome. J Hum Nutr Diet 2011;24:487–495 Barrett JS, Gearry RB, Muir JG, Irving P, Rose R, Haines M, Shepherd SJ, Gibson PR. Dietary poorly absorbed, short-chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon. Aliment Pharmacol Ther. 2010;31:874–882 Maxion-Bergemann, <i>et al</i>. Costs of irritable bowel syndrome in the UK aned US. Pharmacoeconomics 2006;24(1):21–37
AB0767 Cerebral Hemodynamics in Patients with Ankylosing Spondylitis: Table 1.
Authors: U. Uygar, G. Yildirim-Cetin, N. Atilla, K. Gişi, M. Gokce
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> It is known that there is a relationship between systemic inflammation and atherosclerosis. Atherosclerosis is one of the best known causes of cerebrovascular diseases. The aim of this study was to assess the cerebral blood flow velocity with using transcranial Doppler (TCD) ultrasonography in patients with ankylosing spondylitis (AS). <h3>Methods</h3> A total of 30 patients aged 20 to 50-year-old with AS were enrolled in the AS group consecutively. Control group (non-AS group) consisted of 30 age and sex-matched, randomly sampled patients without AS such as fibromyalgia and had no possible risk factors for atherosclerosis. Bilateral middle cerebral artery (MCA) peak-systolic, end-diastolic, and mean blood flow velocities, Gosling9s pulsatility index values, and Pourcelot9s resistance index values were recorded with TCD by a neurosonologist blinded to AS and control groups. <h3>Results</h3> In this study 30 participants in AS group (male/female: 4/26, mean age: 34,7±5,9) and 30 participants in control group (male/female: 4/26, mean age: 32,3±4,7) were evaluated. C-reactive protein (CRP) levels and cerebral blood flow velocities of bilateral MCA were significantly higher in AS group than the control group. This study highlights the persistent clinical and subclinical inflammation regarding atherosclerosis in patients with AS causes increased cerebral blood flow velocities. Our findings provide an insight to this association of AS and neurological manifestations. <h3>Conclusions</h3> This study highlights the persistent clinical and subclinical inflammation regarding atherosclerosis in patients with AS causes increased cerebral blood flow velocities. Our findings provide an insight to this association of AS and neurological manifestations. <h3>Disclosure of Interest</h3> None declared
Prevention of veno-occlusive disease of the liver after bone marrow transplantation: heparin or no heparin? [letter; comment]
Authors: JY Cahn, M Flesch, A Brion, E Deconinck, MF Leconte Des Floris, L Voillat, E Plouvier, D Amsallem, P Tiberghien, T Fest
Journal: Blood (1992)
The Seductress
Authors: Russell Andrew Johnson
Journal: Annals of Internal Medicine (2014)

Letters2 September 2014The SeductressRussell Andrew Johnson, MD, MScRussell Andrew Johnson, MD, MScFrom University of Utah School of Medicine, Salt Lake City, Utah.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L14-5017-2 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Malinoff provides an engaging and highly personal perspective on addiction from a unique vantage point: that of the spouse of a recovering addict and physician. She rightly points out that treatment of addiction is best left to professionals trained in addiction medicine and reiterates the power that addiction holds over those trapped by it. I know all too well from my family's experience with addiction that it is a disease as abhorrent as cancer or any other chronic medical condition that requires daily attention to survive.In my essay, I chose to focus on the dilemma faced ... Author, Article, and Disclosure InformationAuthors: Russell Andrew Johnson, MD, MScAffiliations: From University of Utah School of Medicine, Salt Lake City, Utah.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M13-0962. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Seductress Russell Andrew Johnson The Seductress Lynn Malinoff Metrics 2 September 2014Volume 161, Issue 5Page: 376KeywordsAddictsConflicts of interestDisclosureFallsHealth careMedical conditionsMotivation ePublished: 2 September 2014 Issue Published: 2 September 2014 Copyright & PermissionsCopyright © 2014 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Ash Wednesday
Authors: Chris Adrian
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-047 A multi disciplinary team (mdt) approach for complex benign colo rectal polyps: a tertiary referral centre experience
Authors: Z Tsiamoulos, R Rameshshanker, A Wawszczak, T Elliott, I Beintaris, L Bourikas, M Garg, A Rajendran, H Spranger, S Peake, K Patel, S Thomas-Gibson, A Latchford, A Humphries, J Warusavitarne, A Wilson, O Faiz, R Kennedy, A Haycock, BP Saunders
Journal: Gut (2015)

<h3>Introduction</h3> Multi-disciplinary team (MDT) working is an established part of cancer care. Limited data is available on their impact for benign complex colorectal polyps. Increased numbers of these polyps are referred to our tertiary centre for further management. <h3>Method</h3> Polyp MDT comprising of gastroenterologists, colorectal surgeons and histopathologists was established in January 2013 to discuss the management of complex polyps (large or recurrent polyps or those where endoscopic access was difficult). Cases that were referred to individual consultants and had a provisional management plan made were then discussed at the MDT and a consensus management plan was agreed. The impact of MDT management plan was then evaluated. <h3>Results</h3> 96 cases were discussed between January 2013 and October 2014. Of those 75 (78%) were tertiary referrals. The reasons for polyp complexity included large polyps 53 (55%), those with difficult access 52 (54%) and previous failed attempt 35 (36%). Majority of the polyps were in recto sigmoid, 49 (51%) or in caecum, 32 (32%). In 38 cases (40%) provisional management plan was changed after MDT discussion. This plan was then followed in 80/96 (82%) cases. Combined surgical-endoscopic approaches were proposed in 68 cases (65%). 25/96 patients had polypectomy during a single hospital visit. The remaining cases (71/96) needed further assessment before attempted polypectomy. Complete polypectomy was achieved in 85/96 (89%) of patients: endoscopically in 75/96 cases (78%): 38 by endoscopic excision alone and 37 by combined endo-surgical approaches. Ten polyps were resected surgically. Of the remaining 11 patients no polyps were found in 2 of those referred, 2 patients were referred back their local hospital for surgery, 5 were not fit for a polypectomy and are under surveillance, 1 had metastatic colorectal cancer and 1 declined any intervention. Cancer was found in 7/96 polyps and 6/7 had surgical resection (the remaining patient had metastatic disease). <h3>Conclusion</h3> The polyp MDT consensus management plan led to a change in the proposed management in almost half of the patients. This resulted in complete polypectomy for a large majority of patients referred to our service. <h3>Disclosure of interest</h3> None Declared.
PWE-289 A regional audit on outcomes of endoscopic mucosal resection for colonic polyp cancer
Authors: B Yeung, P Konanahalli
Journal: Gut (2015)

<h3>Introduction</h3> Since the introduction of national colonic screening, the incidence of detection of colonic polyp cancer has increased significantly. Endoscopic mucosal resection (EMR) is the standard technique for excision of polyps. We aim to assess the outcome of polyp cancer management from a prospectively collected database from our regional centralised pathology department. <h3>Method</h3> Our study period was from 01/06/2012—31/07/2013. The census date was 30/01/2015. A prospectively collected database of all polyp cancer patients from the West of Scotland centralised pathology unit was assessed. Management outcome including endoscopic malignant suspicion, resection completeness, recurrence, and subsequent intervention were assessed through electronic patient record. <h3>Results</h3> 35 polyp cancer were detected in 33 patients over 13 month period. Median age of diagnosis was 66.5 (Max 80.4 – Min 52.4). The median size was 15 mm ((Max 34 mm Min 3 mm). EMR was attempted in 32 (91%) polyp cancer. 1 (3%) polyp cancer was managed by transanal minimally invasive surgery. 2 (6%) were treated by primary resection surgery. Of the cancers treated by EMR, 30 (94%) were located in the descending, sigmoid colon and rectum. 7 (22%) had complete excision based on pathology. At census date, 1 patient had recurrence and required colectomy. In 25 (78%) patients, completeness of excision could not be assessed. 6 (24%) patients were managed by surveillance endoscopy and none were found to have recurrence. No complication was observed in surveillance group. 19 (76%) patients were managed by colectomy. 14 (74%) had no evidence of residual disease in the specimen. The morbidity rate was 20%; these included: 1 (5%) pneumonia, 2 (10%) wound infection and 1 (5%) dehiscence. 1 (5%) patient with liver cirrhosis died within thirty days of operation. <h3>Conclusion</h3> A low number of disease recurrence was observed after EMR. Despite the relatively small size and distal position of most detected polyp cancers, completeness of excision could not be assessed in a high number of cases. This leads to a significant number of unnecessary surgery with associated morbitidy and mortality. An increase in adoption of surveillance endoscopy, endoscopic submucosal dissection and flexible endoscopic multitasking platform may improve the management of this group of patients. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Logan RFA, Patnick J, Nickerson C <i>et al</i>. Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests. Gut. 2012;61:1439–1446 Saito Y, Uraoka T, Yamaguchi Y, Hotta K, Sakamoto N, Ikematsu H, Fukuzawa M, Kobayashi N, Nasu J, Michida T, <i>et al</i>. A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video) Gastrointest Endosc. 2010;72:1217–1225
Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease
Authors: Olufolake Adisa, Benjamin Yaw Owusu, Yijuan Hu, Samit Ghosh, Fang Tan, Frederika Sey, Ivy Ekem, Isaac Quaye, Solomon F Ofori-Acquah
Journal: Blood (2013)
Hyperlipemia of Antiserum Nephrosis: I. Rate of Synthesis of Plasma Cholesterol
Authors: H S SODHI, N KALANT
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Liver Catalase Activity in Parabiotic Rats With One Partner Tumor-Bearing&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Balduin Lucké, Mary Berwick, Isolde Zeckwer
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Liver Catalase Activity in Parabiotic Rats With One Partner Tumor-Bearing Get access Balduin Lucké, Balduin Lucké Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary Berwick, Mary Berwick Search for other works by this author on: Oxford Academic PubMed Google Scholar Isolde Zeckwer Isolde Zeckwer Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 3, December 1952, Pages 681–686, https://doi.org/10.1093/jnci/13.3.681 Published: 01 December 1952 Article history Received: 24 July 1952 Published: 01 December 1952
Clinical and phenomenological comparisons of late-onset and early-onset depression
Authors: K R Krishnan, J C Hays, L A Tupler, L K George, D G Blazer
Journal: American Journal of Psychiatry (1995)

The authors examined the relationship between age at onset of first depressive episode and clinical features in elderly depressed patients.They used data on age at onset and clinical features in 246 elderly depressed patients treated at the National Institute of Mental Health Clinical Research Center for the Study of Depression in Later Life, located at Duke University.Two variables--loss of interest and number of depressive episodes--were related to age at onset in all analyses.This study confirms the hypothesis that apathy is more prominent in late-onset than in early-onset depression.