tbuckley/cabot-search huggingface dataset:
PTU-191 Laparoscopic major colonic resections in 80+ age group; is there more to talk about?
Authors: C Jayatilleke, K Sasapu, S Ahmed
Journal: Gut (2015)

<h3>Introduction</h3> With increasing life expectancy in the general population and changing attitudes to the provision of healthcare, an increasing number of octogenarians are offered surgical interventions. Recent advances in laparoscopic surgery and enhanced recovery protocols have enabled surgeons to offer colonic and rectal resection to the premorbid older patients more safely. The aim of this retrospective analysis is to determine the outcome and safety of performing colonic resections in the 80+ age group. <h3>Method</h3> A retrospective analysis was carried out using Electronic notes, patient case notes and Web-V system for pathology for all the patients aged 80 or above, who underwent major colorectal surgery. The Clavien-Dindo classification was used to analyse surgical complications. <h3>Results</h3> In total, 160 colonic resections were done by a single surgeon between May 2011–Jan 2015. 31 of these were aged 80 and above and were analysed further. The male to female ratio was 13:18, median age was 83, and the median duration of stay was 13 days. Median ASA grade was III. Out of these, 6 had (19.4%) anterior resections, 14 (45.2%) had right hemi-colectomy, 3 (9.7%) had left and sigmoid colectomy; 4 (12.9%) had Hartmann’s resection and 4 (12.9%) had APER. 96.7% of the 31 resections were laparoscopic, with the only exception being a resection for recurrent colonic cancer. 10 patients (32.2%) had a permanent stoma, with 1 patient being given a temporary stoma which was subsequently reversed. Cancer classification for these cases were 19.4% (n = 6) Dukes’ A, 45.2% (n = 14) Dukes’ B and 29% (n = 9) Dukes’ C. Analysis of surgical complications showed that 58% (n = 18) had normal course of recovery, 29% (n = 9) had Grade I and II complications, 2 patients had Grade III, and 2 patients had Grades IV and V complications. The patients with Grades IV and V, both suffered anastomotic leaks and were taken back to theatre; and subsequently died of multi-organ failure and sepsis. Five patients required post-operative blood transfusion. Pertinent to note in the total group of 160 resections, there were 4 anastomotic leaks and the two cases in the below 80 age group were managed with laparoscopic washout, with one case requiring a de-functioning stoma. <h3>Conclusion</h3> Laparoscopic colonic resections can be safely performed in octogenarian group with none to moderate post op complications, however their ability to withstand a major post-op complications such as anastomotic leak is poor as evident by two deaths in the group. This risk should be discussed in greater depth during the informed consent process, and should there be any doubt, it should be worth considering a permanent stoma. <h3>Disclosure of interest</h3> None Declared.
SP0128 Common Epigenetic Biomarkers in Chronic Inflammation and Cancer
Authors: C. Ospelt
Journal: Annals of the Rheumatic Diseases (2015)

A variety of changes in epigenetic marks and in the expression of non-coding RNA has been found in cancer as well as in chronic inflammatory diseases. Interestingly, in both diseases similar mechanisms and pathways are affected albeit often to a different extent. In particular changes in the expression of microRNA, but also demethylated gene loci have been proposed as potential biomarkers in cancer as well as in chronic inflammatory diseases. Since the cancer field is much more advanced in the usage of biomarkers for disease subclassifications and subsequent therapeutic decisions, it is worthwhile to take a closer look at the biomarkers, methods and procedures used in oncology and to see which of these could also be applied in predicting disease severity and therapeutic response in rheumatic diseases. This talk will highlight common epigenetic pathways activated in cancer and chronic inflammation and summarize which epigenetic changes have the potential to become biomarkers in rheumatic diseases. <h3>Disclosure of Interest</h3> None declared
Pediatric application of a lumen-apposing metal stent for transgastric pancreatic abscess drainage and subsequent necrosectomy
Authors: Arvind Trindade, Sumant Inamdar, Samuel Bitton
Journal: Endoscopy (2016)

A 14-year-old boy presented to our care with severe necrotizing pancreatitis secondary to a psychiatric medication. He had developed walled-off pancreas necrosis (WOPN) in the body of the pancreas that had become infected, as evidenced by air within a 10-cm collection on computed tomography (CT) scanning, fevers to 102 °F, tachycardia, and leukocytosis.
Minor Surgery and Bandaging.
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Risk of developing tuberculosis from a school contact: retrospective cohort study, United Kingdom, 2009
Authors: M Caley, T Fowler, S Welch, A Wood
Journal: Eurosurveillance (2010)

To quantify the risk of developing tuberculosis (TB) following school contact with a student with smear positive respiratory TB in a population with a high background rate of tuberculosis, a retrospective cohort study was conducted. This study included all students and staff (n=1,065) at an inner city secondary school in Birmingham, United Kingdom (UK). Being in the same school year as the index case resulted in a significantly higher risk of being diagnosed with active TB (odds ratio (OR) 6.11) and either active or latent TB (OR 10.52) compared to the risk for pupils in other school years. Neither lower level classroom exposure in tutoring groups nor being a staff member resulted in significantly increased risk of infection. The number of cases detected in the school was significantly higher than compared with the TB notification rate for the respective age groups in the population in the area. This study is consistent with the small body of evidence that already exists suggesting that greater levels of classroom contact with a student with smear positive active TB significantly increases the risk of contracting active and latent TB. It also suggests that staff may be at a lower risk of active TB than students. It does not appear that being in an area with high TB incidence substantially alters the epidemiology of the outbreak or risk of transmission between students in comparison to other populations.
Mania and bromism: a case report and a look to the future
Authors: A J Sayed
Journal: American Journal of Psychiatry (1976)

Mania has not been reported as a manifestation of bromism. This paper describes a manic patient who had an elevated serum bromide level. The author suggests that the possibility of bromide-induced mania should be considered when patients who manifest manic symptoms are evaluated. The implications of the bromide-mania relationship for a better understanding of manic-depressive illness are also discussed.
The Density of the Rous Sarcoma Virus in Sucrose Solutions
Authors: H. Kahler, W. R. Bryan, B. J. Lloyd, Jr., J. B. Moloney
Journal: JNCI Journal of the National Cancer Institute (1954)

The Density of the Rous Sarcoma Virus in Sucrose Solutions H. Kahler, H. Kahler National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. R. Bryan, W. R. Bryan National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar B. J. Lloyd, Jr., B. J. Lloyd, Jr. National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. B. Moloney J. B. Moloney National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 331–336, https://doi.org/10.1093/jnci/15.2.331 Published: 01 October 1954 Article history Received: 14 June 1954 Published: 01 October 1954
SP0084 Peripheral and Spinal Cord Mechanisms of Pain in Joint Diseases
Authors: N. Eijkelkamp
Journal: Annals of the Rheumatic Diseases (2015)

Chronic pain is a major debilitating problem and affects approximately 20% of the total adult population and is difficult to treat. Pain is the most important defining clinical presentation of osteoarthritis. Knee OA affects approximately 250 million people world wide. Clinically, there is disparity between the degree of pain perception and the extent of joint damage. This disparity between damage and pain is suggestive for specific mechanisms in the sensory nervous system that drive OA pain. In this presentation we discuss potential peripheral mechanisms leading to chronic pain in the context of OA. In addition, underlying spinal mechanisms with a particular focus on spinal neuroinflammation are discussed. <h3>Disclosure of Interest</h3> None declared
Risk factors for homelessness among patients admitted to a state mental hospital
Authors: E S Susser, S P Lin, S A Conover
Journal: American Journal of Psychiatry (1991)

This study measured the overall prevalence of homelessness and tested a priori hypothesized risk factors for homelessness among patients admitted to a state hospital. The risk factors included male gender, age under 40 years, black race, urban residence, schizophrenia-related diagnosis, alcohol abuse, and drug abuse.For 377 patients admitted to a New York state mental hospital, the 3-month, 3-year, and lifetime prevalences of homelessness were assessed. The associations between these prevalences and the hypothesized risk factors were measured by relative risks in univariate analyses and by odds ratios derived from a logistic regression in multivariate analyses.The 3-month prevalence of homelessness was 19%, the 3-year prevalence was 25%, and the lifetime prevalence was 28%. In univariate analyses, significant associations included drug abuse with 3-month prevalence, 3-year prevalence, and lifetime prevalence; urban residence with 3-year prevalence and lifetime prevalence; and age under 40 years with 3-month prevalence. In the logistic regression analyses, the only significant associations were urban residence with 3-year prevalence and lifetime prevalence. Male gender, black race, alcohol abuse, and schizophrenia-related diagnosis had little or no relation to homelessness.The overall prevalence of homelessness in these patients was remarkably high. Several strong risk factors for homelessness in the general population had only a moderate effect or no effect on homelessness in this population. Risk factors for homelessness in psychiatric patients may be somewhat different from those in the general population.
AB0581 Comparable Survival for Filipino Pediatric Lupus Nephritis Even Without Kidney Biopsy
Authors: K.J.B. Taleon, C. Tee
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Kidney biopsy is an important diagnostic tool in planning the treatment for lupus nephritis.<sup>[1]</sup> However, there are circumstances in which biopsy could not be done and treatment has to be rendered immediately. In lieu of this, the Sections of Rheumatology and Nephrology developed a treatment protocol based on clinical data and laboratory findings for pediatric lupus nephritis.<sup>[2]</sup> <h3>Objectives</h3> To describe the clinical profile and outcomes of lupus nephritis pediatric patients in a tertiary care hospital and to compare the clinical outcomes of pediatric patients with SLE nephritis who underwent immunosuppressive therapy guided by kidney biopsy to those who did not but were guided by treatment protocol developed by the sections of Rheumatology and Nephrology of the tertiary hospital. <h3>Methods</h3> This is a retrospective study, which included all patients less than 19 years old diagnosed with lupus nephritis. Patients were categorized depending whether or not treatment plan is guided by the results of a kidney biopsy. The outcome of the patient, effect of treatment and progression to end stage renal disease (ESRD) were measured. <h3>Results</h3> Thirty-one cases of lupus nephritis with mean age of diagnosis at 14.4±2.48 years were included. There were 27 females (87%). Common presentations of renal involvement included edema (74.2%), hematuria (61%), and hypertension (51.6%). Eleven patients had kidney biopsy; the most common classification is class III lupus nephritis (45.4%). The average interval of 7.4±4.08 months from start of induction to performance of biopsy was noted. Majority of the patients were in remission until 18 months study period and five patients died in the said duration. The causes of death identified were septic shock (4) and multiple organ dysfunction (1). The probability of survival is 90% at 6 months and 12 months, and 80% at 18 months. <h3>Conclusions</h3> In our clinical series of 31 patients, lupus nephritis affects females more than males. All patients had immunotherapy before the kidney biopsy was done. Seventy two percent of the patients were in remission by the end of 18 months. Causes of 5mortalities were severe sepsis and multiple organ dysfunction syndrome. Probability survival for patients is noted to be 90% for the first 6-12 months and 80% at 18 months. Clinical findings of pediatric lupus nephritis seem to correlate well with histopathology and the lack thereof should not delay the treatment. <h3>References</h3> Bertsias et al: Joint European League against rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and pediatric lupus nephritis. Annals of Rheumatic Diseases 2012: 71: 1771-1782. Gulay and Dans: Clinical presentations and outcomes of Filipino juvenile systemic lupus erythematosus. Pediatric rheumatology 2011 9:7. <h3>Disclosure of Interest</h3> None declared
Fibrinogen-endothelial cell interaction in vitro: a pathway mediated by an Arg-Gly-Asp recognition specificity
Authors: LR Languino, S Colella, A Zanetti, A Andrieux, JJ Ryckewaert, MH Charon, PC Marchisio, EF Plow, MH Ginsberg, G Marguerie
Journal: Blood (1989)
A cluster of measles cases in Denmark following importation, January and February 2008
Authors: M Muscat, A H Christiansen, B  E Böttiger, A Plesner, S Glismann
Journal: Eurosurveillance (2008)

Five cases of measles were reported to the Department of Epidemiology in Denmark between mid-January and early February, 2008. The cluster involved four adults aged between 23 and 39 years and an infant. All cases resided in the greater Copenhagen area. Three cases were unvaccinated, one was vaccinated with two doses, and in one case the vaccination status is not yet known.
THE KIDNEY IN HEPATIC DISEASE
Authors: O E AUFRANC, W N JONES, W G STEWART
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0279 The Vitamin D Status in Ankylosing Spondylitis in Relation to Intestinal Inflammation, Disease Activity, Osteoproliferation, Bone Mineral Density and Vertebral Fractures
Authors: E. Klingberg, G. Oleröd, O. Hammarsten, H. Forsblad-d'Elia
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Vitamin D insufficiency is common in many regions of the world and a poor vitamin D status has been associated with several chronic illnesses, including rheumatoid arthritis and ankylosing spondylitis (AS). Earlier studies on AS have mainly studied the vitamin D levels attained during the summer. At northern latitudes no vitamin D<sub>3</sub> can be produced in the skin during "the vitamin D winter" due to insufficient out-door UVB irradiation and the populations here are then dependent of the dietary intake of vitamin D. <h3>Objectives</h3> We aimed to study the vitamin D levels attained mainly by dietary intake in AS in comparison with healthy controls and in relation to gastrointestinal symptoms and gut inflammation, measured indirectly by fecal calprotectin. The vitamin D levels were also correlated with measures of disease activity, osteoproliferation, bone mineral density (BMD) and vertebral fractures. <h3>Methods</h3> Serum 25-hydroxy vitamin D (25(OH)D) was measured in the late winter in 203 AS patients and 120 healthy controls resident in Gothenburg, Sweden (57°419N, 11°599E). Fecal calprotectin was measured in stool samples. Disease activity was assessed with CRP, ESR, ASDAS<sub>CRP</sub>, BASDAI, BAS-G, BASFI and BASMI. Lateral spine radiographs were scored for osteoproliferation and vertebral fractures using the mSASSS and Genant scores. BMD was measured by Dual-energy X-ray Absorptiometry in the lumbar spine and femoral neck. <h3>Results</h3> Vitamin D insufficiency (a serum 25(OH)D &lt;50 nmol/L) was found in approximately 50% of the AS patients, but serum 25(OH)D was not different from healthy controls and not significantly correlated with fecal calprotectin, gastrointestinal symptoms, disease activity parameters, mSASSS, vertebral fractures or BMD. <h3>Conclusions</h3> The vitamin D status was often poor in the late winter in AS but not different from the healthy controls. No evidence for a connection between subclinical gut inflammation, malabsorption and hypovitaminosis D was found. Serum 25(OH)D was not associated with disease activity, osteoproliferation, vertebral fractures or BMD during the winter months. We suggest that the lower vitamin D levels in AS, previously found by others, is caused by reduced out-door UVB exposure. It is however imperative to diagnose and treat vitamin D insufficiency in AS given the increased risk of osteoporotic fractures associated with the disease. <h3>Disclosure of Interest</h3> None declared
Cytokine therapy with gene-transfected cells: single injection of irradiated granulocyte-macrophage colony-stimulating factor-transduced cells accelerates hematopoietic recovery after cytotoxic chemotherapy in mice
Authors: FM Rosenthal, R Fruh, R Henschler, H Veelken, P Kulmburg, A Mackensen, B Gansbacher, R Mertelsmann, A Lindemann
Journal: Blood (1994)
SP0031 Imaging and Early Arthritis Management, Diagnosis and Monitoring
Authors: P. Emery
Journal: Annals of the Rheumatic Diseases (2015)

Diagnosis of rheumatoid arthritis has become critical as evidence accrues that the earlier the treatment is given, the better the outcome. Imaging has a crucial role to play in enabling earlier diagnosis. It can: Identify erosions when x-rays are normal. Can change the diagnosis by identifying sub-clinical inflamation which allows the requisite number of joints to be identified as synoptic for the diagnosis of RA to be fulfilled. For monitoring, imaging can assess whether a response to therapy has occurred, when it is difficult to assess clinically, and therefore can lead to continuation or discontinuation of therapy at an earlier stage with benefits for patient and for costs. For patients who have reached stable state it is possible assess whether they have suppressed inflammation completely, in which case dose reduction can be considered or if not whether further therapy is required. The evidence that further therapy impacts on long-term outcome is being investigated. <h3>Disclosure of Interest</h3> None declared
Benzodiazepines and exposure-based cognitive behavior therapies for panic disorder: conclusions from combined treatment trials
Authors: D A Spiegel, T J Bruce
Journal: American Journal of Psychiatry (1997)

Concurrent use of benzodiazepines and psychotherapy for panic disorder is a prevalent but highly controversial practice. Although there are many rationales for that approach, critics contend that benzodiazepines foster drug abuse and dependence and undermine psychosocial treatments in various ways. The authors examine that controversy in the light of recent empirical findings and offer some tentative conclusions and recommendations.Data from studies combining benzodiazepines and the leading psychosocial treatment for panic disorder, exposure-based cognitive behavior therapy, are reviewed, and their application to clinical practice is discussed.The strongest support for combined treatment is for the addition of cognitive behavior therapy to pharmacotherapy for patients with agoraphobia and for those whose benzodiazepine treatment is being discontinued. The greatest problem with combined treatment is relapse after drug discontinuance.Combined treatment may be advantageous for some patients, but it must be carefully designed to avoid potential problems. Suggestions for that are given.