tbuckley/cabot-search huggingface dataset:
AB0122 Correlation Studies between Anoctamin 6 Gene Polymorphism and Expression and Ankylosing Spondylitis
Authors: M. Yang, Z. Hu, Y. Zhang, Q. Li, J. Gu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Objectives</h3> To explore the gene polymorphism of a new susceptibility gene Anoctamin 6 (ANO6) related to disease risk of Ankylosing Spondylitis (AS), and the abnormal expression of ANO6 in AS patients. And provide theoretical basis for ANO6 involved in the pathogenesis of AS. <h3>Methods</h3> Direct sequencing was performed to explore disease-related SNP in exon and transcription regulatory region of ANO6 between 417AS patients and 541 healthy controls (HCs), and linkage disequilibrium and haplotype analysis was used with candidate SNP. RT-PCR was performed to test the difference of the expression of mRNA in peripheral blood mononuclear cells (PBMCs) between 40 AS patients and 32 HCs. Immunohistochemistry was employed to discover the difference of protein expression in tendon tissues between 9 AS patients and 5 control subjects. <h3>Results</h3> Age and sex were not significantly different between AS cases and controls. Our study found that risk alleles of 5 SNP loci (rs79662606, rs76186361, rs17095830, rs80224086 and rs75712006)had a significant correlation with the susceptibility of AS, and strong linkage disequilibrium among each two of SNP loci. Haplotype analysis dicovered a higher proportion of GTGCG, CATGTA and ACGTA in cases (p&lt;0.001). The expression of mRNA of peripheral blood mononuclear cells is 0.49±0.21 in AS cases and 0.86±0.38 in HCs, and the difference is significant (p&lt;0.001). The expression of ANO6 protein went up in tendon tissues (p=0.001), and average Histoscore of IHC in 9 AS patients (182.22±30.732) was significantly higher than in 5 controls (62.00±35.637)(P=0.001). <h3>Conclusions</h3> ANO6 is the new susceptibility gene of AS and risky haplotype is GTGCG, ATGTA and ACGTA. The risky haplotype have no relationship with phenotype of AS. The expression of mRNA of PBMCs decreased while the expression of ANO6 protein went up in tendon tissues, which suggested that ANO6 might participant in the generation and development of AS. <h3>Disclosure of Interest</h3> None declared
A Comprehensive Analysis on the Agreement and Correlation of Consensual Cut-Offs of High on-Treatment Platelet Reactivity with the Vasodilator-Stimulated Phosphorylation Assay, the VerifyNow P2Y12 Analyzer and Light Transmittance Aggregometry
Authors: In-Suk Kim, Young-Hoon Jeong, Eun Yup Lee, Gyeong-Won Lee
Journal: Blood (2011)
Overall Hydroxymethylation Levels As an Independent Prognostic Marker in Intermediate-Cytogenetic Risk Acute Myeloid Leukemia
Authors: Marina Díaz-Beyá, Alfons Navarro, Rut Tejero, Marta Pratcorona, Tania Díaz, Mariano Monzó, Jordi Esteve
Journal: Blood (2012)
Obesity and Cancer Mechanisms: Cancer Metabolism
Authors: Benjamin D. Hopkins, Marcus D. Goncalves, Lewis C. Cantley
Journal: Journal of Clinical Oncology (2016)

Obesity is a risk factor for cancer development and is associated with poor prognosis in multiple tumor types. The positive energy balance linked with obesity induces a variety of systemic changes including altered levels of insulin, insulin-like growth factor-1, leptin, adiponectin, steroid hormones, and cytokines. Each of these factors alters the nutritional milieu and has the potential to create an environment that favors tumor initiation and progression. Although the complete ramifications of obesity as it relates to cancer are still unclear, there is convincing evidence that reducing the magnitude of the systemic hormonal and inflammatory changes has significant clinical benefits. This review will examine the changes that occur in the obese state and review the biologic mechanisms that connect these changes to increased cancer risk. Understanding the metabolic changes that occur in obese individuals may also help to elucidate more effective treatment options for these patients when they develop cancer. Moving forward, targeted clinical trials examining the effects of behavioral modifications such as reduced carbohydrate intake, caloric restriction, structured exercise, and/or pharmacologic interventions such as the use of metformin, in obese populations may help to reduce their cancer risk.
Correlates of tuberculosis risk: predictive biomarkers for progression to active tuberculosis
Authors: Elisa Petruccioli, Thomas J. Scriba, Linda Petrone, Mark Hatherill, Daniela M. Cirillo, Simone A. Joosten, Tom H. Ottenhoff, Claudia M. Denkinger, Delia Goletti
Journal: European Respiratory Journal (2016)

New approaches to control the spread of tuberculosis (TB) are needed, including tools to predict development of active TB from latent TB infection (LTBI). Recent studies have described potential correlates of risk, in order to inform the development of prognostic tests for TB disease progression. These efforts have included unbiased approaches employing “omics” technologies, as well as more directed, hypothesis-driven approaches assessing a small set or even individual selected markers as candidate correlates of TB risk. Unbiased high-throughput screening of blood RNAseq profiles identified signatures of active TB risk in individuals with LTBI, ≥1 year before diagnosis. A recent infant vaccination study identified enhanced expression of T-cell activation markers as a correlate of risk prior to developing TB; conversely, high levels of Ag85A antibodies and high frequencies of interferon (IFN)-γ specific T-cells were associated with reduced risk of disease. Others have described CD27 − IFN-γ + CD4 + T-cells as possibly predictive markers of TB disease. T-cell responses to TB latency antigens, including heparin-binding haemagglutinin and DosR-regulon-encoded antigens have also been correlated with protection. Further studies are needed to determine whether correlates of risk can be used to prevent active TB through targeted prophylactic treatment, or to allow targeted enrolment into efficacy trials of new TB vaccines and therapeutic drugs.
P0839 : Evaluation of drug–drug interactions between the fixed-dose combination of daclatasvir/asunaprevir/beclabuvir and methadone or buprenorphine/naloxone
Authors: X. Tao, K. Sims, M. Hesney, S. Lubin, M. Stonier, M. Wind-Rotolo, L. Reynolds, D. Liang, J. Pursley, M. AbuTarif
Journal: Journal of Hepatology (2015)
Knockdown Of Matrix Metalloproteinase 13 (MMP13) In 5TGM1 Multiple Myeloma Cells Inhibits Development Of Lytic Bone Lesions In Vivo
Authors: Jing Fu, Shirong Li, Huihui Ma, G. David Roodman, Markus Y. Mapara, Stephen J Weiss, Suzanne Lentzsch
Journal: Blood (2013)
Impact of Tyrosine Kinase Inhibitor (TKI) in Chronic Myeloid Leukemia (CML) Relapsing After T Cell Depleted Allogeneic Stem Cell Transplantation (SCT)
Authors: Sawa Ito, Minoo Battiwalla, Eleftheria K. Koklanaris, Jeanine Superata, Richard Childs, A. John Barrett
Journal: Blood (2011)
Phenotypic Aberrations of Myeloid CD34+ Cells in Patients with Myelodysplastic Syndrome (MDS): Clinical Significance and Correlation with Cytogenetics Abnormalities.
Authors: Dolores Subira, Patricia Font, Eva Arranz, Ramiro B Soraya, Susana Castanon, Mónica Renedo, Carlos Blas, Maria F. Garcia B, Olga Gonzalez B, José F. Tomas, José M. Fernandez-Rañada
Journal: Blood (2004)
Human Cord Blood-Derived CD34-Negative Hematopoietic Stem Cells (HSCs): A New Class of HSCs in the Human HSC Hierarchy
Authors: Keisuke Sumide, Yoshikazu Matsuoka, Ryusuke Nakatsuka, Hiroshi Kawamura, Tatsuya Fujioka, Yutaka Sasaki, Hiroaki Asano, Yoshiaki Sonoda
Journal: Blood (2015)
SNP Genotypes as Prognostic Factors Associated with Staging in Myeloma: The First Combined SNP Association Analysis of SWOG, ECOG, and MRC Clinical Trials from the Bank on a Cure.
Authors: Brian Van Ness, John Crowley, Emily Blood, Erik Rasmussen, Christine Ramos, Suzanne Grindle, Gareth Morgan, David Johnson, Antje Hoering, Philip Greipp, Bart Barlogie, Brian Durie
Journal: Blood (2005)
Quantitative Real Time PCR Analysis of MDR1 Transduced Rhesus Macaque Hematopoietic Stem Cells Shows No Indication for Proliferative Advantage after Long-Term Follow-Up.
Authors: Farastuk Bozorgmehr, Stephanie Laufs, Eike C. Buss, Katalina Z. Nagy, Stephanie E. Sellers, W. Jens Zeller, Cynthia E. Dunbar, Stefan Fruehauf
Journal: Blood (2005)
Response to Hypomethylating Agents in Myelodysplastic Syndromes Based on WHO 2008 Subtypes and IPSS-R Stratification and Impact on Survival
Authors: Hassan B Alkhateeb, Muhanad Hreh, Moussab Damlaj, Michelle Elliott, William J Hogan, Mrinal M Patnaik, Mark R Litzow, Aref Al-Kali
Journal: Blood (2015)
Lesion Size and Perspective in Acute Ischemic Stroke
Authors: David S. Liebeskind
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Pharmacokinetic and Pharmacodynamic Studies of Lestaurtinib (CEP-701) and PKC-412: Cytotoxicity Is Often Dependent on Non-FLT3-Mediated Effects.
Authors: Mark Levis, Adam Stine, Rosalyn, B. Douglas Smith, Judith Karp, Richard Stone, Elihu Estey, Frank Giles, Hagop Kantarjian, Pamela Cohen, Yanfeng Wang, Donald Small
Journal: Blood (2005)
Skipping breakfast and poor sleep linked to childhood obesity, study finds
Authors: Susan Mayor
Journal: BMJ (2016)

Skipping breakfast and having irregular bedtimes, as well as having a mother who smoked during pregnancy, were important risk factors for obesity in childhood and adolescence, a UK cohort study has found.1

Researchers analysed data collected from 16 936 children taking part in the Millennium Cohort Study. They calculated body mass index (BMI) at ages 3, 5, 7, and 11 years, and collected information on the mother’s pregnancy, …
Differences In Clinical-Biological Features and Outcome Between Diffuse Large B-Cell Lymphomas Of HIV-Infected and Non-HIV-Infected Patients Treated With RCHOP In The CART Era
Authors: Maria Joao Baptista, Mireia Morgades, Olga Garcia, Miriam Moreno, Juan Manuel Sancho, Fuensanta Millá, Evarist Feliu, Josep-Maria Ribera, Jose-Tomas Navarro
Journal: Blood (2013)
A Minor Population of CD55−CD59− Blood Cells Detected by Two-Color Flow Cytometry in Aplastic Anemia Patients: A Reliable Marker for Good Response to Immunosuppressive Therapy.
Authors: Chiharu Sugimori, Tatsuya Chuhjo, Xuzhang Lu, Xingmin Feng, Ken Ishiyama, Hirohito Yamazaki, Akiyoshi Takami, Shinji Nakao
Journal: Blood (2004)
Recovery of Renal Function and Independence from Dialysis in Newly Diagnosed and Relapsed Multiple Myeloma Patients - A Single Instituition Experience.
Authors: Girish Ravindranathan, Tanya Indrakumar, Sohail Ahmad, Moez Dungarwalla, Pamela Kanagasabapathy, Jane Merceica, Katherine Rice, Mary Clarke Clarke, Ann-Britt Jones, David Makunjola, Judith Behrens
Journal: Blood (2007)
Sirolimus/Tacrolimus Facilitates Preferential Recovery of Regulatory T Cells (Treg) After Allogeneic Hematopoietic Cell Transplantation (HCT), and Is More Effective Than Methotrexate/Tacrolimus in Preventing Grade II-IV Acute Graft Vs. Host Disease (GVHD) and Moderate to Severe Chronic Gvhd
Authors: Joseph Pidala, Jongphil Kim, Heather Jim, Hugo F. Fernandez, Marcie Tomblyn, Mohamed A Kharfan-Dabaja, Brian C. Betts, Taiga Nishihori, Mian Xu, William E. Janssen, Frederick L Locke, Ernesto Ayala, Lia Perez, Janelle Perkins, Teresa Field, Leonel Ochoa, Melissa Alsina, Claudio Anasetti
Journal: Blood (2011)
Predictive Value for Engraftment and Survival of Total Nucleated Cell Dose (TNC) as Compared to CD34+ Cell Dose after Autologous and Allogeneic Bone Marrow Transplant (BMT) for Hematologic Malignancies.
Authors: Adetola A. Kassim, Shin Mineishi, Madan Jagasia, Madhuri Vurisikala, Stacey Goodman, John P. Greer, Wichai Chinratanalab, Katherine Ruffner, David S. Morgan, Richard S. Stein, Stephen Brandt, Friedrich G. Schuening
Journal: Blood (2004)
Correlation Between Increases in Apoptosis in Primary Mediastinal B-Cell Lymphoma (PMBL) and NF-κB Pathway Blockade: Bortezomib (BTZ), Small Molecule IKK Inhibitor ML120B and Combination Therapy Significantly Decrease NF-κB Family Member Protein Activation
Authors: Ian Waxman, Dongxu Xie, Carmella van de Ven, Janet Ayello, Nancy Day, Megan S Lim, Sherrie L. Perkins, Mitchell S. Cairo
Journal: Blood (2008)
Bone Marrow Microenvironmental Overexpression of DKK1, HGF, Frizzled-Related Protein B, and Syndecan-1 Are Associated with the Degree of Osteolytic Bone Disease in Multiple Myeloma Patients
Authors: Jacob Haaber, Gitte Birk Kerndrup, Maria Lyng, Thomas L. Andersen, Niels Pallisgaard, Niels Abildgaard
Journal: Blood (2008)
PTU-086 Suboptimal Performance of Shearwave Elastography (ElastPQ) for Predicting Advanced Fibrosis in a Nafld Enriched Cohort: Abstract PTU-086 Table 1
Authors: R Bevan, B Stenberg, M Madhra, A McNeill, S McPherson
Journal: Gut (2016)

<h3>Introduction</h3> It is important to identify those at risk of advanced liver fibrosis in order to stratify care. Histological assessment by liver biopsy (LBx) is the gold standard for staging liver fibrosis, but is impractical for widespread use. Several non-invasive measures of fibrosis, such as transient elastography and simple markers (FIB4 score and AST/ALT ratio (AAR)) have shown promise as alternatives to LBx. Shearwave elastography (SWE), assessed using acoustic radiation force impulses (ARFI), offers a potential alternative technique that can be performed on a conventional ultrasound machine. To date, few studies have evaluated the Phillips ElastPQ system, particularly in patients with non-alcoholic fatty liver disease (NAFLD). Our aim was to evaluate the accuracy of SWE using ElastPQ compared with liver biopsy in a “real world” cohort. <h3>Methods</h3> Patients undergoing LBx between Sept 2014-Dec 2015 who had SWE conducted at the time of LBx were included. Clinical and demographic data were collected from the time of LBx. The AAR and FIB4 scores were calculated. Liver fibrosis was staged from 0–4; stage 3–4 was considered advanced fibrosis. SWE was conducted by experienced sonographers. SWE values (m/s) were defined as normal (&lt;1.21), fibrotic (1.21–1.55) or advanced fibrosis/cirrhotic (&gt;1.55). <h3>Results</h3> 92 patients were identified (52% male; median age 51 yrs, range 20–90). LBx diagnoses were: 57 NAFLD, 10 AIH, 9 PBC, 6 HBV/HCV and 10 other. Median biopsy size was 20 mm (IQR 16.2–24). Overall, there was significant correlation between SWE and fibrosis stage (r = 0.44 p &lt;0.001) and the FIB4 score (r = 0.32 p =0.004). Table 1 shows a Cross-tabulation of SWE fibrosis categories against fibrosis stage. Patients who were correctly classified with SWE are shown in bold. Worryingly, 6 patients (24%) with advanced fibrosis had a “normal” SWE reading. For all patients, the area under the receiver operator curve (AUROC) for a diagnosis of advanced fibrosis was 0.73 for SWE (sensitivity[sen] 46%, specificity[sp] 78% at 1.55 m/s), 0.81 for the FIB4 score (sen 85%, sp 65% at 1.3) and 0.8 for the AAR (sen 76%, sp 73% at 0.8). When the 57 NAFLD patients were analysed separately the AUROCs for advanced fibrosis were 0.72, 0.84 and 0.83 for SWE, FIB4 and AAR respectively. <h3>Conclusion</h3> In this real world cohort, SWE using ElastPq had suboptimal performance and missed clinically significant advanced fibrosis in 24% of cases. It appears that this technique does not perform as well in patients with NAFLD as other liver diseases, such as viral hepatitis. <h3>Disclosure of Interest</h3> None Declared
Functional Difference of Two Tie2 Ligands, Angiopoietin-1 and -2, in the Regulation of the Adult Bone Marrow Hematopoietic Stem Cells
Authors: Yumiko Gomei, Fumio Arai, Hiroki Yoshihara, Hiroko Iwasaki, Kentaro Hosokawa, Yuka Nakamura, Toshio Suda
Journal: Blood (2008)
Edoxaban had similar efficacy to and better safety than warfarin in AF, regardless of previous stroke or TIA
Authors: Andrew Dunn
Journal: Annals of Internal Medicine (2016)

Source Citation Rost NS, Giugliano RP, Ruff CT, et al; ENGAGE AF-TIMI 48 Investigators. Outcomes with edoxaban versus warfarin in patients with previous cerebrovascular events: findings from ENGAGE AF-TIMI 48 (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48). Stroke. 2016;47:2075-82. 27387994
Distribution of Estimated 10-Year Risk of Recurrent Vascular Events and Residual Risk in a Secondary Prevention Population
Authors: Lotte Kaasenbrood, S. Matthijs Boekholdt, Yolanda van der Graaf, Kausik K. Ray, Ron J.G. Peters, John J.P. Kastelein, Pierre Amarenco, John C. LaRosa, Maarten J.M. Cramer, Jan Westerink, L. Jaap Kappelle, Gert J. de Borst, Frank L.J. Visseren
Journal: Circulation (2016)

Among patients with clinically manifest vascular disease, the risk of recurrent vascular events is likely to vary. We assessed the distribution of estimated 10-year risk of recurrent vascular events in a secondary prevention population. We also estimated the potential risk reduction and residual risk that can be achieved if patients reach guideline-recommended risk factor targets.The SMART score (Second Manifestations of Arterial Disease) for 10-year risk of myocardial infarction, stroke, or vascular death was applied to 6904 patients with vascular disease. The risk score was externally validated in 18 436 patients with various manifestations of vascular disease from the TNT (Treating to New Targets), IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering), SPARCL (Stroke Prevention by Aggressive Reduction in Cholesterol Levels), and CAPRIE (Clopidogrel Versus Aspirin in Patients at Risk of Ischemic Events) trials. The residual risk at guideline-recommended targets was estimated by applying relative risk reductions from meta-analyses to the estimated risk for targets for systolic blood pressure, low-density lipoprotein cholesterol, smoking, physical activity, and use of antithrombotic agents.The external performance of the SMART risk score was reasonable, apart from overestimation of risk in patients with 10-year risk >40%. In patients with various manifestations of vascular disease, median 10-year risk of a recurrent major vascular event was 17% (interquartile range, 11%-28%), varying from <10% in 18% to >30% in 22% of the patients. If risk factors were at guideline-recommended targets, the residual 10-year risk would be <10% in 47% and >30% in 9% of the patients (median, 11%; interquartile range, 7%-17%).Among patients with vascular disease, there is very substantial variation in estimated 10-year risk of recurrent vascular events. If all modifiable risk factors were at guideline-recommended targets, half of the patients would have a 10-year risk <10%. These data suggest that even with optimal treatment, many patients with vascular disease will remain at >20% and even >30% 10-year risk, clearly delineating an area of substantial unmet medical need.
SP0193 Nine Years of Marriage and Three in Bed - Myself, My Husband and My RA
Authors: C. Zabalan
Journal: Annals of the Rheumatic Diseases (2016)

The most difficult adjustment within a life-threatening chronic illnesses and disabilities involves sexual activities. Communicating openly and directly with partners, doctors and other health care professionals is not always easy in this field. People often have trouble discussing sexual issues or simply feel lucky to manage on their own in the daily program, therefore, as if they don9t have the right to “complain” about changes in sexual functioning. Problems that we ran into everyday, problems like joint movement limitations, chronic pain, chronic fatigue, weakness, stiffness, decreased mobility, decreased libido, altered genital sensation, vaginal dryness, side effects from medications (for example, risk for infections, weight gain or bloating) they affect all aspects of our lives (personal, family, professional and social) - they all can affect our self-esteem, self-image and, of course, our sexuality. We have negative moods, we have feelings like resentment, anger, guilt, grief, blame, depression, fears of isolation and of being rejected sexually, worries about sexually satisfying one9s partner… Solutions like acceptance, 100% communication, an individualized physical activity, planning the intercourse, devoting plenty of time to foreplay, devising a communication code for pain and pleasure, comfortable and safe positions, alternate ways to enjoy sex, learning some of the 64 Kama Sutra techniques and mastering some of the ancient arts a courtesan used to know, using sex toys and sex toy adjustments … are all here, presented in my personal view. <h3>Conclusion</h3> Arthritis can lead to various sexual problems that require constant adjustment on the part of the individual with arthritis and the couple. But keeping in mind that “<i>our most powerful sex organs, as they always say, are our minds” will make us feel self-worth and will reassure ourselves that we are deserving a strong, loving, committed emotional and physical relationship.</i> <h3>Disclosure of Interest</h3> None declared
Determinants of Phenotypic Commitment and Clonal Progression--Conclusions from the Study of Clonal Architecture in CMML
Authors: Bhumika J. Patel, Bartlomiej Przychodzen, Michael J. Clemente, Cassandra M. Hirsch, Tomas Radivoyevitch, Swapna Thota, Thomas LaFramboise, Hirotoshi Sakaguchi, Seiji Kojima, Hetty E. Carraway, Mikkael A. Sekeres, Seishi Ogawa, Hideki Makishima, Jaroslaw P. Maciejewski
Journal: Blood (2015)
Large Hiatal Hernia
Authors: Carolina C Sousa, Joana Duarte
Journal: New England Journal of Medicine (2016)

An 81-year-old woman presented with vomiting. Chest radiography showed a large air–liquid shadow in the inferior retrocardiac position, suggesting a paraesophageal hernia. CT showed a large retrocardiac mass that was consistent with herniation of the stomach into the chest.