tbuckley/cabot-search huggingface dataset:
Propensity score analysis: Frontline therapy with high-dose (HD) imatinib vs. 2nd generation tyrosine kinase inhibitors in patients with chronic myeloid leukemia in chronic phase.
Authors: Koji Sasaki, Hagop M. Kantarjian, Elias Jabbour, Farhad Ravandi, Koichi Takahashi, Marina Konopleva, Gautam Borthakur, Guillermo Garcia-Manero, William G. Wierda, Naval Guastad Daver, Preetesh Jain, Sherry Pierce, Mary Beth Rios, Jorge E. Cortes
Journal: Journal of Clinical Oncology (2015)

7022 Background: The clinical efficacy of the second generation of tyrosine kinase inhibitors (TKI) has not been compared to that of HD imatinib in patients (pts) with chronic myeloid leukemia in chronic phase (CML-CP). Methods: Response and survival for 374 pts with newly diagnosed CML-CP enrolled in four consecutive or parallel prospective clinical trials of imatinib 800 mg daily, dasatinib, or nilotinib were analyzed. Logistic regression was used for propensity score (PS) calculation from baseline pt characteristics including age at diagnosis, gender, race, Sokal scores, white blood cell, hemoglobin, platelet, blasts in peripheral blood and bone marrow, albumin, urea nitrogen, creatinine, lactate dehydrogenase, total bilirubin, the proportion of Philadelphia chromosome by conventional karyotype and fluorescence in situ hybridization, the presence of clonal evolution, the type of BCR-ABL transcript, and time from diagnosis to therapy. PS analysis with 1:1 matching was performed with the nearest matching method. The Kaplan-Meier method was used to calculate OS, EFS, TFS, and FFS. Results: Of the 374 pts analyzed, 158 were treated with HD imatinib, 109 with nilotinib, and 107 with dasatinib. The median follow-up was 124 months, 49 months, and 54 months, respectively. PS matching identified 81 pts in imatinib vs. dasatinib and 84 pts in imatinib vs. nilotinib, respectively. The cumulative best response, five-year OS, EFS, TFS, and FFS are summarized in the table below. Conclusions: High-dose imatinib may have similar efficacy compared to second generation TKIs without clear difference in response or long-term survival endpoints. Main outcomes after PS matching. IM800 [n = 84] Nilotinib [n = 84] P IM800 [n = 81] Dasatinib [n = 81] P BCR-ABL < 10% at 3 months 96 94 .724 97 95 .683 Cumulative Response within 1 year, (%) CMR 19 18 .945 21 16 .511 MR4.5 49 42 .670 46 42 .847 MMR 83 82 .247 81 77 .878 CCyR 93 93 .540 89 91 .248 Cumulative Response within 3 year, (%) CMR 35 26 .306 33 30 .612 MR4.5 64 55 .325 64 65 .869 MMR 90 87 .939 88 85 .646 CCyR 94 89 .708 90 93 .576 5-y Outcome, (%) FFS 72 70 .989 69 75 .679 TFS 96 90 .361 92 93 .685 EFS 89 87 .728 82 90 .210 OS 94 92 .863 91 98 .219
Early relapse following initial therapy for multiple myeloma predicts poor outcomes in the era of novel agents
Authors: N Majithia, S V Rajkumar, M Q Lacy, F K Buadi, A Dispenzieri, M A Gertz, S R Hayman, D Dingli, P Kapoor, L Hwa, J A Lust, S J Russell, R S Go, R A Kyle, S K Kumar
Journal: Leukemia (2016)
Shaping Components of Assertive Behavior with Instructions and Feedback
Authors: Richard M. Eisler, Michel Hersen, Peter M. Miller
Journal: American Journal of Psychiatry (1974)

The authors describe the use of instructions and immediate feedback in sequentially shaping target assertive behaviors. Deficiencies in assertive behavior were assessed in two subjects by means ofratings of videotaped interactions. Training involved rehearsals of standard assertive situations unrelated to the subjects' real-life problems. There was relatively rapid acquisition of component assertive behaviors during training. These improvements also generalized to untreated rehearsals of the su~jects' real-life problems. The clinical implications of the training procedures are discussed.
In Vivo Selection of Wild-Type Hematopoietic Stem Cells in a Murine Model of Fanconi Anemia
Authors: Kevin P. Battaile, Raynard L. Bateman, Derik Mortimer, Jean Mulcahy, R. Keaney Rathbun, Grover Bagby, William H. Fleming, Markus Grompe
Journal: Blood (1999)
Symptoms of major depression among Mexican-Americans and non-Hispanic whites
Authors: J M Golding, M Karno, C M Rutter
Journal: American Journal of Psychiatry (1990)

The lifetime prevalence of symptoms of a major depressive episode was estimated in two large samples of randomly selected community residents that included many Mexican-Americans. Approximately 5% to 40% of the subjects reported each symptom cluster. The rates for Mexican-Americans born in the United States resembled those for non-Hispanic whites born in the United States; however, the rates for Mexican-Americans born in Mexico were lower in eight of nine symptoms clusters. Language differences did not account for this pattern. Cultural similarity to non-Hispanic whites born in the United States was associated with a higher rate of depressive symptoms.
Induced NCX1 overexpression attenuates pressure overload-induced pathological cardiac remodelling
Authors: Yoshihiro Ujihara, Keiichiro Iwasaki, Satomi Takatsu, Ken Hashimoto, Keiji Naruse, Satoshi Mohri, Yuki Katanosaka
Journal: Cardiovascular Research (2016)

Aims Although increased Na+/Ca2+ exchanger 1 (NCX1) expression is observed during heart failure (HF), the pathological role of NCX1 during the progression of HF remains unclear. We examined alterations of NCX1 expression and activity in hearts after transverse aortic constriction (TAC) surgery and explored whether NCX1 influences pressure overload-induced pathological cardiac remodelling.
3′-Azido 3′-Deoxythymidine + Methotrexate as a Novel Antineoplastic Combination in the Treatment of Human Immunodeficiency Virus-Related Non-Hodgkin's Lymphomas
Authors: Patrizia Tosi, Filippo Gherlinzoni, Patrizio Mazza, Giuseppe Visani, Olga Coronado, Paolo Costigliola, Enzo Raise, Magda Mazzetti, Francesco Gritti, Francesco Chiodo, Sante Tura
Journal: Blood (1997)
Pfizer blocks sales of its drugs for executions
Authors: Owen Dyer
Journal: BMJ (2016)

The pharmaceutical company Pfizer has announced measures to block the sale of its products for the use in capital punishment, which means that all 25 Food and Drug Administration approved makers of potential lethal injection drugs have now declared their opposition to such use.

“Pfizer makes its products to enhance and save the lives of the patients we serve,” the company said in a statement released on Friday 13 May. “Consistent with these values, Pfizer strongly objects to the use of its products as lethal injections for capital punishment.”1

Pfizer took on several potential execution drugs last year when it acquired Hospira Inc, a company that had been at the forefront of efforts to keep drugs …
Lack of association between cortisol hypersecretion and nonsuppression on the DST in patients with Alzheimer's disease
Authors: A H Miller, G Sastry, A J Speranza, B A Lawlor, R C Mohs, T M Ryan, S M Gabriel, M Serby, J Schmeidler, K L Davis
Journal: American Journal of Psychiatry (1994)

Among 23 patients with Alzheimer's disease, 11 (48%) exhibited cortisol hypersecretion (> or = 11.8 micrograms/dl) and nine (39%) displayed cortisol nonsuppression on the dexamethasone suppression test. Only four patients exhibited both neuroendocrine abnormalities, demonstrating a lack of association between these two neuroendocrine disturbances of over 50%. Twenty-two of the 23 patients were studied for 4 1/2 years, and 14 died during that period. Six of the eight surviving patients exhibited cortisol hypersecretion without cortisol nonsuppression.
Outbreak of salmonellosis in a kindergarten in Estonia, May 2008
Authors: I Dontšenko, N Võželevskaja, A Põld, N Kerbo, K Kutsar
Journal: Eurosurveillance (2008)

The Estonian Health Protection Inspectorate (HPI) is investigating an outbreak of salmonellosis in a kindergarten in Harju County. As of 28 May 2008, 94 salmonellosis cases had been reported, including 85 children and nine employees of the kindergarten. Of the 94 cases, 71 were laboratory-confirmed for Salmonella enteritidis and 23 were shown to be epidemiologically linked.
A preliminary investigation of alexithymia in men with psychoactive substance dependence
Authors: G J Taylor, J D Parker, R M Bagby
Journal: American Journal of Psychiatry (1990)

The prevalence of alexithymia in a group of newly abstinent male substance abusers (N = 44) was 50%. The alexithymic patients had significantly less ego strength and repressive defensive behavior and significantly higher levels of somatic complaints and general dysphoria.
Traveling new streets. A compact with the people
Authors: F. J. Jirka
Journal: JAMA (1983)

In ascending to the highest elective office of our Federation, I stand before you acutely aware of both the size and the import of the attendant responsibilities. I also stand before you with my first message as your President. It will be a straightforward and plainspoken message, and it is a message I hope AMA Delegates and other physicians will share with our colleagues back home. My message has to do with a different kind of medical marketplace that is fast developing in this country, a marketplace characterized by increased competition and pronounced changes in reimbursement and delivery. My message has to do with the challenges posed for everyone concerned. It has to do with the societal challenges, with the economic challenges, and with the governmental challenges associated with the marketplace. It has to do with the need for the American people to understand that since we all have contributed
Update on Colorectal Polyps: Management and Follow-Up Surveillance
Authors: J H Bond
Journal: Endoscopy (2003)

Available scientific data and considerable clinical experience indicate that over 95 % of colorectal cancers arise in benign adenomatous polyps that develop and advance very slowly over many years. Interruption of this adenoma–carcinoma sequence by finding and resecting polyps is a highly effective method of preventing colorectal cancer. Colonoscopy is the procedure of choice for both the diagnosis and resection of colorectal polyps. Patients who have had colonoscopic resection of adenomas, and in some cases their close relatives, are at a higher than average risk for developing future polyps and cancer, and likely will benefit from periodic follow-up colonoscopic surveillance. This surveillance should to be tailored to the perceived risk of each individual case depending on the features of the resected adenomas and other patient factors such as family history. Widespread adoption of current polyp guideline recommendations would be highly protective and yet would conserve medical resources.
The Effect of Podophyllotoxin on the Skin of the Mouse, with Reference to Carcinogenic, Cocarcinogenic, and Anticarcinogenic Action
Authors: I. Berenblum
Journal: JNCI Journal of the National Cancer Institute (1951)

The Effect of Podophyllotoxin on the Skin of the Mouse, with Reference to Carcinogenic, Cocarcinogenic, and Anticarcinogenic Action Get access I. Berenblum I. Berenblum Special Research Fellow National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 4, February 1951, Pages 839–841, https://doi.org/10.1093/jnci/11.4.839 Published: 01 February 1951 Article history Received: 14 November 1950 Published: 01 February 1951
Case 24-1966
Authors: Bernard M. Jacobson, Wallace H. Clark
Journal: New England Journal of Medicine (1966)

Presentation of CaseAn eighty-four-year-old retired plumber entered the hospital because of weakness.He had been well until five months previously, when there was the onset of weakness, occasional night sweats and anorexia, with a loss of 28 pounds in weight. Many years earlier he had been told that he had a "spot on the lung." Examination in the Medical Clinic three months before admission was unremarkable except for enlargement of the prostate gland. The urine gave a trace test for protein. The hemoglobin was 13.9 gm. per 100 ml., and the white-cell count 7100. The urea nitrogen was 15 . . .
Effects of fluoxetine on regional cerebral blood flow in obsessive- compulsive patients
Authors: R Hoehn-Saric, G D Pearlson, G J Harris, S R Machlin, E E Camargo
Journal: American Journal of Psychiatry (1991)

Six drug-free obsessive-compulsive patients were given single photon emission computerized tomography scans before and during treatment with fluoxetine. The treatment significantly reduced the patients' "hyperfrontality," as determined by the ratio between medial-frontal and whole cerebral cortex blood flow, and significantly lowered ratings of obsessive-compulsive and anxiety symptoms.
Case 4-1972
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, John J. Calabro, Benjamin Castleman
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 16-year-old boy was admitted to the hospital because of joint pain.He had been well until one month previously, when there was the onset of malaise, anorexia and fever. On the next day pain in the left hip developed. The pain interfered with his gait and was relieved by rest; it subsided spontaneously after several days and was followed by pain and limitation of motion in both shoulders, hips and knees. During the week before entry the temperature rose to 38.9°C. A physician administered penicillin and aspirin for two days, without response, and referred the patient . . .
Recognizing Measles
Authors: Amy E. Thompson
Journal: JAMA (2015)

Recognizing MeaslesMeasles is a highly contagious disease that is caused by a virus. How Measles Is SpreadMeasles is spread when an infected person coughs or sneezes.Small droplets containing the virus disperse into the air and onto nearby surfaces, where the virus can live for up to 2 hours.Another person can become infected by breathing contaminated air or through contact with a contaminated surface.A person who is infected with measles can spread the disease to others even before any symptoms appear.Measles is one of the most contagious diseases known.This means that it spreads easily from an infected person to others who are not immune to the disease.People who are fully vaccinated against measles, who have had the disease, or who were born in the United States before 1957 are considered immune.
Stopping Time
Authors: Alexandra E. Page
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemic Herpetic Stomatitis in an Orphanage Nursery
Authors: Bobby D. Hale, Robert C. Rendtorff, Lillie C. Walker, Audrey N. Roberts
Journal: JAMA (1963)

An unusual outbreak of herpes simplex stomatitis occurred in a group of 13 children 11 mo to 35 mo of age. Herpes simplex virus was isolated from eight of the ten children with clinically apparent illness. In all cases, the viruses which were isolated in HeLa cell cultures caused cytopathic effects identical to those of the proliferative strain of herpes simplex virus and characterized by rounding and clumping of cells without formation of syncytia. Serologic studies demonstrated a rise in serum-neutralizing antibodies in all eight symptomatic children whose sera were available, and no rise in the three asymptomatic children. This outbreak was characterized by its unusually high attack rate, the nature of the strain of the virus isolates, and the lack of in-apparent infection.
Macrophage colony-stimulating factor receptor marks and regulates a fetal myeloid-primed B-cell progenitor in mice
Authors: Alya Zriwil, Charlotta Böiers, Lilian Wittmann, Joanna C. A. Green, Petter S. Woll, Sten Eirik W. Jacobsen, Ewa Sitnicka
Journal: Blood (2016)
Reliability and concordance in the subtyping of schizophrenia
Authors: A M Gruenberg, K S Kendler, M T Tsuang
Journal: American Journal of Psychiatry (1985)

The authors examined the reliability, frequency, concordance, and demographic characteristics of subtypes of schizophrenia in patients from the Iowa 500 study as defined by four major diagnostic systems: DSM-III, Research Diagnostic Criteria (RDC), ICD-9, and the Tsuang-Winokur criteria. Reliability was higher in diagnostic systems with operationalized than in those with unoperationalized criteria and consistently higher for the paranoid subtype. The frequency of individual subtypes varied widely for the different systems. Concordance for subtype diagnoses between systems ranged from quite high to quite low. Demographic characteristics of the individual subtypes were similar according to all systems.
Reed-Sternberg cells in spinal fluid.
Authors: W Caceres, L Delgado, J R Sanchez
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.10.3289 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9336368 Reed-Sternberg cells in spinal fluid. W CaceresxW CaceresSearch for articles by this author , L DelgadoxL DelgadoSearch for articles by this author , J R SanchezxJ R SanchezSearch for articles by this author Show More San Juan Veterans Administration Hospital, Puerto Rico. https://doi.org/10.1200/JCO.1997.15.10.3289 PDF "Reed-Sternberg cells in spinal fluid.." Journal of Clinical Oncology, 15(10), pp. 3289–3290© 1997 by American Society of Clinical Oncology
Biomarker Analyses of Clinical Outcomes in Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib with or without Erlotinib in the SEARCH Trial
Authors: Andrew X. Zhu, Yoon-Koo Kang, Olivier Rosmorduc, T.R. Jeffry Evans, Armando Santoro, Paul Ross, Edward Gane, Arndt Vogel, Michael Jeffers, Gerold Meinhardt, Carol E.A. Peña
Journal: Clinical Cancer Research (2016)

Sorafenib is the current standard therapy for advanced hepatocellular carcinoma, but validated biomarkers predicting clinical outcomes are lacking. This study aimed to identify biomarkers predicting prognosis and/or response to sorafenib, with or without erlotinib, in hepatocellular carcinoma patients from the phase III SEARCH trial.
Abstract P6-09-14: Awareness of brest cancer risk factors among lay persons and physicians
Authors: J-F Morère, J Viguier, J-Y Blay, C Touboul, C Lhomel, F Eisinger, X Pivot
Journal: Cancer Research (2016)

Abstract Background The EDIFICE surveys have been conducted every three years since 2005. The aim of the surveys is to provide a better understanding of the participation of the French population in cancer screening programs. The breast cancer screening program is nowadays widely implemented throughout the female population aged 50-74 years; however, the question of whether it could be adapted according to breast cancer risk factors is currently under debate. This analysis focuses on awareness of the nature of breast cancer risk factors among the lay population and physicians. Methods This fourth nationwide observational survey, EDIFICE 4, was conducted by phone interviews using the quota method. A representative sample of 1602 individuals aged between 40 and 75 years old was interviewed between June 12 and July 10, 2014. A mirror survey on a representative sample of 201 general practitioners (adjusted for age and geographical area) and 100 oncologists (adjusted for type of healthcare institution and geographical area) was conducted between July 9 and August 8, 2014. Interviewees were all asked to cite five main risk factors for breast cancer. Results For lay persons (737 women with no history of cancer), the breast cancer risk factors reported were: for 54%, heredity and family history; for 29%, unhealthy lifestyle, including smoking, poor diet, stress, alcohol, physical inactivity; for 15%, exposure to exogenous hormone therapy; for 4%, air pollution; for 4%, sunburn on breasts; for 4%, late childbearing or no childbearing, and for 2%, overweight/obesity. Among physicians (70 female general practitioners and 35 female oncologists), the breast cancer risk factors reported were: for 98%, heredity and family history; for 51%, exposure to exogenous hormone therapy; for 39%, late childbearing or no childbearing; for 32%, unhealthy lifestyle, including smoking, poor diet, stress, alcohol, physical inactivity; for 22%, overweight/obesity; for 20%, age; for 22%, no breast feeding, and for 2%, air pollution. Conclusion We observed a relatively satisfactory level of understanding regarding the different risk factors for breast cancer despite the lack of indication of any qualitative ranking. Although overweight is a known risk factor for breast cancer, this fact is still not clearly understood among physicians and not widely known by the general public. On the other hand, both physicians and also half of the lay population were well aware of the fact that heredity is a risk factor for breast cancer. Citation Format: Morère J-F, Viguier J, Blay J-Y, Touboul C, Lhomel C, Eisinger F, Pivot X. Awareness of brest cancer risk factors among lay persons and physicians. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-09-14.
What is compassion and how can we measure it? A review of definitions and measures
Authors: Clara Strauss, Billie Lever Taylor, Jenny Gu, Willem Kuyken, Ruth Baer, Fergal Jones, Kate Cavanagh
Journal: Clinical Psychology Review (2016)

The importance of compassion is widely recognized and it is receiving increasing research attention. Yet, there is lack of consensus on definition and a paucity of psychometrically robust measures of this construct. Without an agreed definition and adequate measures, we cannot study compassion, measure compassion or evaluate whether interventions designed to enhance compassion are effective. In response, this paper proposes a definition of compassion and offers a systematic review of self- and observer-rated measures. Following consolidation of existing definitions, we propose that compassion consists of five elements: recognizing suffering, understanding the universality of human suffering, feeling for the person suffering, tolerating uncomfortable feelings, and motivation to act/acting to alleviate suffering. Three databases were searched (Web of Science, PsycInfo, and Medline) and nine measures included and rated for quality. Quality ratings ranged from 2 to 7 out of 14 with low ratings due to poor internal consistency for subscales, insufficient evidence for factor structure and/or failure to examine floor/ceiling effects, test–retest reliability, and discriminant validity. We call our five-element definition, and if supported, the development of a measure of compassion based on this operational definition, and which demonstrates adequate psychometric properties.