tbuckley/cabot-search huggingface dataset:
The Interaction of Polynuclear Hydrocarbons With Mouse-Skin Protein&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Herbert I. Hadler, Violet Darchun, Katharine Lee
Journal: JNCI Journal of the National Cancer Institute (1959)

Binding to protein was observed when a series of four C14-labeled poly-nuclear hydrocarbons were mixed with disintegrated mouse skin. Although processes in vivo may occur, such interaction prevents the conclusive demonstration of the binding in vivo of any chemical substance when methods involving cellular disintegration are employed.
Optimal management of residual mass after chemotherapy in advanced seminoma: there is time for everything.
Authors: S Culine, J P Droz
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.10.2884 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8874350 Optimal management of residual mass after chemotherapy in advanced seminoma: there is time for everything. S CulinexS CulineSearch for articles by this author , J P DrozxJ P DrozSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.10.2884 PDF "Optimal management of residual mass after chemotherapy in advanced seminoma: there is time for everything.." Journal of Clinical Oncology, 14(10), pp. 2884–2885© 1996 by American Society of Clinical Oncology
Hunt acknowledges junior doctors’ unhappiness
Authors: Gareth Iacobucci
Journal: BMJ (2016)

England’s health secretary, Jeremy Hunt, has admitted that he failed to understand the root causes of junior doctors’ unhappiness in the protracted industrial dispute over a new contract.

After a series of strikes by junior doctors this year, the government and the BMA finally reached a breakthrough in May and agreed a set of terms that junior doctors must now decide whether to accept.1

In a keynote speech at the NHS Confederation’s annual conference in Manchester this week, Hunt conceded that he had not previously understood that much of junior doctors’ frustration arose from issues such as inflexible training and rostering. …
Incidence trends in pertussis in the Autonomous Region of Madrid, Spain: 1982-2005
Authors: I Vera, L García-Comas, M Ordobas, A Gutierrez, J C Sanz, D Barranco
Journal: Eurosurveillance (2007)

The objective of this study was to describe the incidence (1982-2005) and epidemiologic characteristics of pertussis cases (1998-2005) in the Autonomous Region of Madrid using data drawn from the epidemiologic surveillance network and computerised hospital discharge data. In the 1990s, the trend in the pertussis incidence in the Autonomous Region of Madrid was clearly falling. The typical seasonal pattern of pertussis remained. A peak in incidence were observed in 2000, and another peak, 2.5 times higher, in 2003. They affected all age groups, but children under one year of age were the most frequent cases, followed by the five to nine year-olds. The greatest increase was seen in the age groups from 10 to 14 and from five to nine. Since 2002, the proportion of cases diagnosed serologically has increased. The incidence of hospital discharges among small children exceeded that of reported cases. More than half of the cases with known vaccination status had received at least three doses of vaccine. The upward trend observed since 2002 could be due to improved case detection, availability of serologic techniques, and a rise in the susceptible population aged five to 14 years. The fact that epidemic peaks continue to occur and that there is a seasonality to the disease seems to indicate that despite the vaccination programme the circulation of the bacteria has not been interrupted. The introduction of the acellular vaccine in 2000 does not appear to have played a significant role in the increase in disease incidence.
Tumors, Innocent and Malignant; Their Clinical Features and Appropriate Treatment.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TB-04PROTEOMICS ANALYSIS OF CEREBROSPINAL FLUID (CSF) FROM CHILDREN WITH CNS TUMOURS IDENTIFY CANDIDATE PROTEINS RELATING TO TUMOUR METASTATIC SPREAD
Authors: Filippo Spreafico, Italia Bongarzone, Sara Pizzamiglio, Ruben Magni, Elena Taverna, Maida De Bortoli, Chiara Maura Ciniselli, Elena Barzanò, Veronica Biassoni, Alessandra Luchini, Lance Liotta, Paolo Verderio, Maura Massimino
Journal: Neuro-Oncology (2016)
CSF monoamine metabolites in mania
Authors: A C Swann, S Secunda, J M Davis, E Robins, I Hanin, S H Koslow, J W Maas
Journal: American Journal of Psychiatry (1983)

As part of the National Institute of Mental Health Clinical Research Branch Collaborative Program on the Psychobiology of Depression, the authors compared concentrations of CSF monoamine metabolites (the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol [MHPG], the dopamine metabolite homovanillic acid [HVA], and the serotonin metabolite 5-hydroxyindoleacetic acid [5-HIAA]) from 14 hospitalized manic patients with concentrations from 62 healthy comparison subjects. The manic patients had significantly higher levels of MHPG. Levels of 5-HIAA and HVA did not differ between the manic patients and the comparison male subjects, but they were elevated in the female manic patients. MHPG was the only metabolite that correlated significantly with mania symptom ratings. These data are consistent with findings that have shown abnormal, perhaps excessive, central noradrenergic activity in patients with mania, but not with those suggesting deficits in serotoninergic function.
Nasal polyps and sinusitis
Authors: Raymond G Slavin
Journal: JAMA (1997)

Despite the prevalence and long history of nasal polyps, many questions still exist with respect to incidence and pathogenesis. Although allergy has been commonly thought to be a major cause, much compelling evidence argues against this. Medical therapy consists of a short course of systemic steroids followed by intranasal steroids. Sinusitis is the most commonly reported chronic disease in the United States. Decrease in ostial size, retention of secretions, and decrease in mucociliary action all contribute to the pathogenesis of sinusitis. The clinical presentation of chronic sinusitis is generally subtle and the clinical index of suspicion must be high. Limited coronal computed tomography is regarded as the most definitive and cost-effective imaging technique for the diagnosis of sinusitis. Appropriate antibiotics must be administered for a sufficient period. In medically resistant sinusitis, functional endoscopic sinus surgery has emerged as the procedure of choice.
A Case of Cronkhite-Canada Syndrome Involving the Entire Gastrointestinal Tract
Authors: S. Junk, W. Zegarski, P. Bilinski
Journal: Endoscopy (2001)

We encountered a case of a 56-year-old woman with Cronkhite-Canada syndrome who presented with chronic diarrhea, alopecia, intermittent abdominal pain, hyperpigmentation, and nail dystrophy (Figure [1]). Her face, palms, and the back of her hands and soles of her feet were deeply pigmented with small dark brown spots. Her family history was noncontributory. Serum total protein was 5.4 g/dl, with 2.4 g/dl of albumin. Endoscopic examination of the stomach showed multiple sessile polyps, varying in size from 2 mm to 10 mm throughout the entire stomach and duodenum (Figure [2]). Small-bowel x-ray and colonoscopic examination revealed multiple polyps from the jejunum to the rectum. Histopathologic examination of these polyps revealed edema of the lamina propria, and mucosal erosion associated with evidence of chronic inflammation. Scintigraphy with technetium-99m-labeled human albumin demonstrated a protein-losing enteropathy. Hyperalimentation (2200kcal/d) was continued for 8 weeks. At 1 week later, the patient's diarrhea showed a decrease in severity, with improvement in appetite and weight gain. However, the diarrhea recurred after 2 weeks. After administration of prednisolone, 30 mg daily, and trimethoprim with sulfamethoxazole (Bactrim), clinical improvement was noted, with cessation of diarrhea, increased serum protein, disappearance of pigmentation, and regrowth of the scalp hair.
Leukocytosis and presence of CALR mutation is associated with non-hepatosplenic extramedullary hematopoiesis in primary myelofibrosis
Authors: D Barraco, T L Lasho, N Gangat, C Finke, Y C Elala, A Pardanani, A Tefferi
Journal: Blood Cancer Journal (2016)

Leukocytosis and presence of  CALR  mutation is associated with non-hepatosplenic extramedullary hematopoiesis in primary myelofibrosis
Elimination of Granulocytic Myeloid‐Derived Suppressor Cells in Lupus‐Prone Mice Linked to Reactive Oxygen Species–Dependent Extracellular Trap Formation
Authors: Katerina Vlachou, Konstantinos Mintzas, Maria Glymenaki, Marianna Ioannou, Garyfalia Papadaki, George K. Bertsias, Prodromos Sidiropoulos, Dimitrios T. Boumpas, Panayotis Verginis
Journal: Arthritis & Rheumatology (2015)

Objective Emerging evidence supports a crucial role of myeloid‐derived suppressor cells (MDSCs) in the regulation of autoimmune diseases. However, their role in systemic lupus erythematosus (SLE) remains unknown. This study sought to address the role of MDSCs in the pathogenesis of SLE. Methods MDSCs from (NZB × NZW)F1 lupus‐prone mice were assessed for phenotype by flow cytometry, and the function of MDSCs was analyzed by in vitro T cell proliferation assay and real‐time quantitative polymerase chain reaction. Extracellular trap (ET) formation was evaluated by immunofluorescence and confocal microscopy. The production of reactive oxygen species (ROS) by Ly‐6G+ cells was determined by fluorescence‐activated cell sorting analysis. Results Expansion of MDSCs was impaired and the function of MDSCs was defective in the lymphoid organs of (NZB × NZW)F1 lupus‐prone mice with established disease, in which involvement of predominantly the granulocytic MDSC (G‐MDSC) cell subset was observed. More specifically, the results showed that increased elimination of G‐MDSCs, driven by the inflammatory milieu of lupus, could be attributed to ET formation, and that cytokines, such as interferon‐α (IFNα), IFNγ, and interleukin‐6, play a role in this process. Induction of ET release by G‐MDSCs was mediated by the production of ROS, since inhibition of ROS generation significantly reduced ET release. Conclusion Collectively, the results of this study reveal that elimination of a crucial regulatory immune cell subset is a feature of the SLE microenvironment. These findings provide new insights into the pathogenetic mechanisms of the disease.
Sequencing of noncrossresistant agents.
Authors: J H Goldie
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.8.1513 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2072153 Sequencing of noncrossresistant agents. J H GoldiexJ H GoldieSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.8.1513 PDF "Sequencing of noncrossresistant agents.." Journal of Clinical Oncology, 9(8), pp. 1513–1514© 1991 by American Society of Clinical Oncology
AKI and Long-Term Risk for Cardiovascular Events and Mortality
Authors: Ayodele Odutayo, Christopher X. Wong, Michael Farkouh, Douglas G. Altman, Sally Hopewell, Connor A. Emdin, Benjamin H. Hunn
Journal: Journal of the American Society of Nephrology (2016)

AKI associates with increased long-term risk of mortality, but the prognostic significance of AKI in terms of long-term cardiovascular disease remains unconfirmed. We conducted a systematic review and meta-analysis to assess whether AKI associates with long-term cardiovascular disease. We included cohort studies that examined adults with and without AKI and reported a multivariable-adjusted relative risk (RR) for the association between AKI and cardiovascular mortality, major cardiovascular events, and disease-specific events: congestive heart failure, acute myocardial infarction, and stroke. Twenty-five studies involving 254,408 adults (55,150 with AKI) were included. AKI associated with an 86% and a 38% increased risk of cardiovascular mortality and major cardiovascular events, respectively ([RR 1.86; 95% confidence interval (95% CI), 1.72 to 2.01] and [RR 1.38; 95% CI, 1.23 to 1.55], respectively). For disease-specific events, AKI associated with a 58% increased risk of heart failure (RR 1.58; 95% CI, 1.46 to 1.72) and a 40% increased risk of acute myocardial infarction (RR 1.40; 95% CI, 1.23 to 1.59). The elevated risk of heart failure and acute myocardial infarction persisted in subgroup analyses on the basis of AKI severity and the proportion of adults with baseline ischemic heart disease. Finally, AKI was associated with a 15% increased risk of stroke (RR 1.15; 95% CI, 1.03 to 1.28). In conclusion, AKI associates with an elevated risk of cardiovascular mortality and major cardiovascular events, particularly heart failure and acute myocardial infarction.
Cardiac Nuclear Medicine.
Authors: Cindy C Parman
Journal: Annals of Internal Medicine (1987)

Documentation of the specific nuclear medicine procedure performed should include whether the test represents the following: Perfusion or blood pool study. Planar or SPECT images. First pass or gated equilibrium (multiple-gated acquisition). Single or multiple studies. Criteria for the performance of add-on procedure codes. This will ensure that the correct procedure codes are reported and result in appropriate reimbursement.
Intestinal Carcinoma and Other Lesions in Mice Following Oral Administration of 1,2,5,6-Dibenzanthracene and 20-Methylcholanthrene&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Egon Lorenz, Harold L. Stewart
Journal: JNCI Journal of the National Cancer Institute (1940)

Intestinal Carcinoma and Other Lesions in Mice Following Oral Administration of 1,2,5,6-Dibenzanthracene and 20-Methylcholanthrene Egon Lorenz, Egon Lorenz senior physicist National Cancer Institute, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Stewart Harold L. Stewart senior pathologist National Cancer Institute, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 1, Issue 1, 1940-1941, Pages 17–40, https://doi.org/10.1093/jnci/1.1.17 Published: 01 August 1940
A phase III, open-label, randomized study of eribulin mesylate versus capecitabine in patients with locally advanced or metastatic breast cancer (MBC) previously treated with anthracyclines and taxanes: Subgroup analyses.
Authors: Peter Andrew Kaufman, Javier Cortes, Ahmad Awada, Louise Yelle, Edith A. Perez, Jantien Wanders, Martin S. Olivo, Yi He, Corina Dutcus, Christopher Twelves
Journal: Journal of Clinical Oncology (2013)

1049^ Background: This phase III study, comparing eribulin versus capecitabine, showed a non-significant trend for superior overall survival (OS; hazard ratio [HR] 0.88 [95% confidence interval (CI) 0.77, 1.00]; p = 0.056) but not progression-free survival (PFS; HR 1.08 [95% CI 0.93, 1.25]; p = 0.31). Pre-specified exploratory subgroup analyses previously presented showed that patients with triple-negative, ER-negative or HER2-negative disease may have a greater benefit in OS with eribulin compared with capecitabine. Here we present further pre-specified exploratory analyses of OS and PFS. Methods: Patients (eribulin n=554; capecitabine n=548) with locally advanced or MBC had received ≤3 prior chemotherapy regimens (≤2 for advanced disease), including an anthracycline and a taxane. Patients were randomized (stratified for geographic region and HER2 status) 1:1 to 21-day cycles of eribulin mesylate 1.4 mg/m 2 i.v. on days 1 and 8 or capecitabine 1.25 g/m 2 BID orally on days 1-14. Further pre-specified exploratory subgroups included: age; receptor status; number and setting of prior chemotherapy regimen(s); sites of disease; number of organs involved; and time to progression after last chemotherapy. Results: From analyses for OS, patients with only non-visceral disease (HR 0.51; 95% CI 0.33, 0.80), with &gt;2 organs involved (HR 0.75; 95% CI 0.62, 0.90), who had progressed &gt;6 months after last chemotherapy (HR 0.70; 95% CI 0.52, 0.95), or who had received an anthracycline and/or a taxane in the metastatic setting (HR 0.84; 95% CI 0.72, 0.98), appeared to benefit more from treatment with eribulin compared with capecitabine. For OS, in no subgroup was a trend favoring capecitabine seen. Data for other pre-specified subgroups for both OS and PFS will be presented. Conclusions: In addition to patients with triple-, ER-, or HER2-negative disease, further pre-specified exploratory analyses suggest that other patient subgroups may particularly benefit from treatment with eribulin; further studies are warranted to address these hypotheses. Clinical trial information: NCT00337103.
Extent of Resection and Survival in Glioblastoma Multiforme—Reply
Authors: Timothy J. Brown, Michael Glantz
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
MB-36COMBINED CLINICAL PARAMETERS WITH SPECIFIC MRI FEATURES YIELD HIGHLY ACCURATE PREDICTION OF MEDULLOBLASTOMA SUBTYPES: DATA FROM 72 PATIENTS IN A BLINDED STUDY
Authors: Archya Dasgupta, Tejpal Gupta, Sona Pungavkar, Neelam Shirsat, Abhishek Mahajan, Amit Janu, Girish Chinnaswamy, Epari Sridhar, Jayant Goda, Aliasgar Moiyadi, Prakash Shetty, Shraddha Churi, Rakesh Jalali
Journal: Neuro-Oncology (2016)
Recombinant human interleukin-3 expands the pool of circulating hematopoietic progenitor cells in primates--synergism with recombinant human granulocyte/macrophage colony-stimulating factor
Authors: K Geissler, P Valent, P Mayer, E Liehl, W Hinterberger, K Lechner, P Bettelheim
Journal: Blood (1990)
Exotic Landscape
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ga-67-avid non-Hodgkin's lymphoma arising from chronic nontuberculous pyothorax.
Authors: KAZUYOSHI SUGA, YUKO ISHIKAWA, KAZUMI MOTOYAMA, NORIKO FUJIMURA, HIROKI SUDA, NAOFUMI MATSUNAGA
Journal: Clinical Nuclear Medicine (2001)

SUGA, KAZUYOSHI M.D.; ISHIKAWA, YUKO M.D.; MOTOYAMA, KAZUMI M.D.; FUJIMURA, NORIKO M.D.; SUDA, HIROKI M.D.; MATSUNAGA, NAOFUMI M.D. Author Information
Candidate gene study of eight GABAA receptor subunits in panic disorder
Authors: R R Crowe, Z Wang, R Noyes, B E Albrecht, M G Darlison, M E Bailey, K J Johnson, T Zoëga
Journal: American Journal of Psychiatry (1997)

gamma-Aminobutyric acid type A (GABAA) receptor subunit genes are candidate genes for panic disorder. Benzodiazepine agonists acting at this receptor can suppress panic attacks, and both inverse agonists and antagonists can precipitate them. The human GABAA receptor subtypes are composed of various combinations of 13 subunits, each encoded by a unique gene. The authors tested eight of these subunits in a candidate gene linkage study of panic disorder.In 21 U.S. and five Icelandic multiplex pedigrees of panic disorder, 104 individuals had DSM-III-R panic disorder (the narrowly defined affected phenotype) and 134 had either this diagnosis or subsyndromal panic disorder characterized by panic attacks that failed to meet either the criterion of attack frequency or the number of criterion symptoms necessary for a definite diagnosis (the broadly defined affected phenotype). The authors conducted lod score linkage analyses with both phenotypes using both a dominant and a recessive model of inheritance for the following loci: GABRA1-GABRA5 (alpha 1-alpha 5), GABRB1 (beta 1), GABRB3 (beta 3), and GABRG2 (gamma 2).The results failed to support the hypothesis that any of these genes cause panic disorder in a majority of the pedigrees.Within the limitations of the candidate gene linkage method, panic disorder does not appear to be caused by mutation in any of the eight GABAA receptor genes tested.