tbuckley/cabot-search huggingface dataset:
Outcome study of first-episode psychosis. I: Relapse rates after 1 year
Authors: C J Rabiner, J T Wegner, J M Kane
Journal: American Journal of Psychiatry (1986)

One-year relapse rates were assessed in a group of 64 patients diagnosed by Research Diagnostic Criteria who were hospitalized for their first psychotic episode. Life-table analysis showed that of the 51 remitted patients, 71.4% of the schizophrenic patients (N = 20), 71.4% of patients with affective disorders (N = 10), and 77.8% of patients diagnosed as having either unspecified functional psychosis or other psychiatric disorder (N = 7) remained in remission at 1-year follow-up. Factors associated with relapse or poor outcome (patients who remained in episode) included no maintenance medication, longer duration of illness, and premorbid asociality.
Injury and illness in aquatic sport: how high is the risk? A comparison of results from three FINA World Championships
Authors: Annika Prien, Margo Mountjoy, Jim Miller, Kevin Boyd, Cees van den Hoogenband, David Gerrard, Mohamed Yahia Cherif, Yifan Lu, Kyriakos Nanousis, Edgar Ivan Ortiz Liscano, Farhad Moradi Shahpar, Astrid Junge
Journal: British Journal of Sports Medicine (2016)

Background Epidemiological information on injury/illness is required to develop effective injury prevention strategies. Aim To assess the frequency and characteristics of injuries/illnesses (1) in the 4 weeks prior to and (2) during the Fédération Internationale de Natation (FINA) World Championships 2015 compared with 2013 and 2009. Method (1) Athletes answered a retrospective questionnaire, and (2) the medical staff reported injuries/illnesses prospectively during the championships. Results (1) A quarter of responding athletes reported symptoms in the 4 weeks prior to the championships. More than half of all affected athletes presented with substantial severity, 80% took medication, 70% had overuse injuries and 30% did not modify their training regime despite symptoms. At the start of the championships, 70% of affected participants were still symptomatic. (2) During the championships, injury and illness incidence was 12.9 per 100 athletes. The most common injuries were shoulder sprains (5.7%) and muscle cramps of the lower back (5.7%). The most common illnesses were infections of the respiratory (33.9%) and gastrointestinal tract (23.5%). Risk factors included discipline and age, but not gender. Incidence was highest in athletes competing in high diving (HD), water polo (WP) and diving (DIV) for injuries, and WP and swimming (SW) for illnesses. The significantly higher incidence of injuries and illnesses at the FINA World Championships 2015 compared with 2013 and 2009 was most probably due to a similarly improved response rate of the medical staff. Conclusions In aquatic sports, surveillance and health promotion should focus on prevention of out-of-competition overuse injuries and athlete education.
Melancholic subtyping: a qualitative or quantitative distinction?
Authors: M Zimmerman, W Coryell, B Pfohl
Journal: American Journal of Psychiatry (1986)

Melancholic depressed subjects scored significantly higher than did nonmelancholic subjects both on the depressive symptoms used and those not used for melancholic subtyping. The results suggest that DSM-III's melancholic criteria do not identify a qualitatively distinct subgroup, but instead reflect illness severity.
LG-25PEDIATRIC LOW-GRADE GLIOMAS WITH CRAF GENE FUSIONS RESPOND DIFFERENTIALLY TO TARGETED THERAPEUTICS BASED ON DIMERIZATION PROFILES
Authors: Payal Jain, Tamara Fierst, Amanda Silva, Aesha Vakil, Harry Han, Phillip J. Storm, Angela J. Waanders, Adam Resnick
Journal: Neuro-Oncology (2016)
The making of the psychiatrist-executive
Authors: M A Silver, L R Marcos
Journal: American Journal of Psychiatry (1989)

The authors reviewed the literature on the factors influencing the development of psychiatrist-executives. The results indicate that personality traits, clinical psychiatry training, training in administration, mentors, and administrative experience have an impact on the making of the psychiatrist-executive. On the basis of these findings, the authors make recommendations for further research.
Community cluster of meningococcal disease by Neisseria meningitidis serogroup C in Andalusia, Spain, March to May 2011
Authors: J M Mayoral Cortés, E Torres Butrón, M García Fernández, Z Herrador Ortiz, S Huarte Osakar, R Santos Luque, E Pérez Morilla, J Guillén Enriquez
Journal: Eurosurveillance (2012)

Binary file ES_Abstracts_Final_ECDC.txt matches
Exposure of Cord Blood Hematopoietic Stem Cells to Bone Marrow Mesenchimal Cells-Derived Microvesicles Induces Cell Survival and Inhibition of Differentiation
Authors: Luciana De Luca, Stefania Trino, Vittorio Simeon, Ilaria Laurenzana, Stefania Raimondo, Marina Podestà, Michele Santodirocco, Lazzaro Di Mauro, Francesco La Rocca, Antonella Caivano, Annalisa Morano, Luigi Del Vecchio, Francesco Frassoni, Daniela Cilloni, Pellegrino Musto
Journal: Blood (2014)
CSF transthyretin in patients with depression
Authors: J A Hatterer, J Herbert, C Hidaka, S P Roose, J M Gorman
Journal: American Journal of Psychiatry (1993)

Some depressed patients may suffer from restricted central hypothyroidism, which could occur if levels of the thyroid hormone transport protein transthyretin were low. CSF transthyretin was measured in eight inpatients with refractory major depression and nine neurological patients. The depressed patients had significantly lower transthyretin levels than the comparison subjects, suggesting that central hypothyroidism, with normal peripheral thyroid concentrations, could occur in some depressed patients.
Sensitivity to subjective effects of cocaine in drug abusers: relationship to cerebral ventricle size
Authors: M J Morgan, N G Cascella, J M Stapleton, R L Phillips, B C Yung, D F Wong, E K Shaya, E D London
Journal: American Journal of Psychiatry (1993)

The purpose of this study was to assess the functional significance of ventricle-brain ratio (VBR) in terms of how it might affect sensitivity to cocaine, an indirect dopamine agonist.Relationships between VBR and subjective responses to acute intravenous cocaine hydrochloride were examined in 20 male polydrug abusers. Tests were performed in conjunction with positron emission tomography scans to measure cerebral glucose metabolism.Subjective measures of effects of cocaine, including self-report ratings of intensity of the drug effect, scores on the morphine-benzedrine scale of the Addiction Research Center Inventory, and several items on visual analogue scales, correlated negatively with VBR. VBR also differed significantly among subjects who were grouped according to scores on items ("rush" and "crash") of the Cocaine-Sensitive Scale (larger VBR in subjects with weaker responses). VBR was not correlated with cocaine-induced changes in cerebral metabolic rates for glucose.Relative insensitivity to the subjective effects of cocaine in polydrug abusers with ventricle enlargement suggests that ventriculomegaly may reflect changes in periventricular brain regions that mediate these effects of cocaine.
Delayed Massive Hemobilia After Biliary Stenting
Authors: F.  Wolters, B.  Ryan, R.  Beets-Tan, C.  Dejong
Journal: Endoscopy (2003)

A 75-year-old man presented with jaundice. His medical history included Billroth II gastrectomy, long-standing alcohol abuse, and aortic stent insertion. A computed tomography (CT) scan showed multiple pancreatic head pseudocysts, atrophy of the pancreatic body and tail, and dilatation of the pancreatic duct and common bile duct (CBD). Endoscopic retrograde cholangiopancreatography (ERCP) revealed dilatation of the intrahepatic ducts and a dilated and tortuous CBD with distal narrowing (Figure [1]). A 15-cm, 10-Fr biliary endoprosthesis was inserted without sphincterotomy, and there was subsequent clinical improvement.
A new pandemic influenza A(H1N1) genetic variant predominated in the winter 2010 influenza season in Australia, New Zealand and Singapore
Authors: I G Barr, L Cui, N Komadina, R T Lee, R T Lin, Y Deng, N Caldwell, R Shaw, S Maurer-Stroh
Journal: Eurosurveillance (2010)

Pandemic H1N1 influenza virus is of global health concern and is currently the predominant influenza virus subtype circulating in the southern hemisphere 2010 winter. The virus has changed little since it emerged in 2009, however, in this report we describe several genetically distinct changes in the pandemic H1N1 influenza virus. These variants were first detected in Singapore in early 2010 and have subsequently spread through Australia and New Zealand. At this stage, these signature changes in the haemagglutinin and neuraminidase proteins have not resulted in significant antigenic changes which might make the current vaccine less effective, but such adaptive mutations should be carefully monitored as the northern hemisphere approaches its winter influenza season.
Reply to Kobiela et al.
Authors: Prashant Kedia, Michel Kahaleh
Journal: Endoscopy (2015)

We thank the authors for taking an interest in our publication and raising some interesting arguments regarding the external EDGE procedure as a novel method for performing endoscopic retrograde cholangiopancreatography (ERCP) in patients with Roux-en-Y gastric bypass (RYGB) anatomy.
&lt;emph type="ital"&gt;Pomona&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An SCF-FBXW7 Ubiquitin Ligase Mediated Feedback Loop Facilitates GATA Factor Switching and Reinforces Commitment to Terminal Erythroid Maturation
Authors: Alireza Ghamari, Elizabeth Jaensch, Richard Giadone, Thomas E Akie, Jian Xu, Daniel Bauer, Stuart H. Orkin, Alan B. Cantor
Journal: Blood (2014)
Evaluation Of The JAK2-V617F Gene Mutation In Egyptian Patients With Essential Thrombocythemia and Polycythemia Vera
Authors: Maha Ibrahim El Zaafarany, A. Hasan Abdel-Ghaffar, Tawfik R. Elkhodary, Dalia A. Salem, Eman A. Soliman, Sameh S. Shamaa
Journal: Blood (2013)
P-068 Prognostic factors related to clinical outcomes by self-expandable metal stent due to Malignant Gastric Outlet Obstruction
Authors: D.I. Jeong, D.G. Yu, J.H. Kim, Y.Y. Choi, D.H. Kang, H.W. Kim, C.W. Choi, S.B. Park, S.J. Kim
Journal: Annals of Oncology (2015)
Decline in influenza vaccine effectiveness with time after vaccination, Navarre, Spain, season 2011/12
Authors: J Castilla, I Martínez-Baz, V Martínez-Artola, G Reina, F Pozo, M García Cenoz, M Guevara, J Moran, F Irisarri, M Arriazu, E Albéniz, C Ezpeleta, A Barricarte, Collective Primary Health Care Sentinel Network, Collective Network for Influenza Surveillance in Hospitals of Navarre
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Preclinical and Early Clinical Activity of the Oral Selective Inhibitor of Nuclear Export (Sine) Exportin 1 (Xpo1) Antagonist Selinexor (Kpt-330) in Patients (Pts) with Platinum Resistant/Refractory Ovarian Cancer (Ovca)
Authors: J. Martignetti, A.R.A. Razak, Y. Chen, N.Y. Gabrail, J.F. Gericitano, C. Camacho, E. Pereira, B. Evans, P. Dottino, D. McCauley, S. Shacham, T. Rashal, J. Saint-Martin, E. Shacham, D. Vincent, M. Kauffman, M.R. Mirza, M. Mau-Sorensen
Journal: Annals of Oncology (2014)
Tumor Cell Proliferation (Ki-67 Index) Overcomes Cytology and Growth Pattern As Prognostic Factor in Mantle-Cell Lymphoma – Results from Randomized Trials of the European MCL Network
Authors: Eva Hoster, Andreas Rosenwald, Francoise Berger, Heinz-Wolfram Bernd, Sylvia Hartmann, Christoph Loddenkemper, Thomas Barth, Nicole Brousse, Stefano Pileri, Grzegorz Rymkiewicz, Roman Kodet, Michael Unterhalt, Johanna C. Kluin-Nelemans, Olivier Hermine, Wolfgang Hiddemann, Martin H. Dreyling, Wolfram Klapper
Journal: Blood (2014)
Modified LSA2-L2 treatment in 53 children with E-rosette-positive T- cell leukemia: results and prognostic factors (a Pediatric Oncology Group Study)
Authors: DJ Pullen, MP Sullivan, JM Falletta, JM Boyett, GB Humphrey, KA Starling, VJ Land, PG Dyment, T Vats, MH Duncan
Journal: Blood (1982)
Association of male breast cancer and prostate cancer: A large population based study.
Authors: Shaheenah S. Dawood, Joanne Ngeow Yuen Yie, Paul N. Mainwaring, Sudeep Gupta, Javier Cortes, Bhawna Sirohi, Rebecca Alexandra Dent
Journal: Journal of Clinical Oncology (2016)

1541 Background: Breast cancer is rare among men and associated with germline BRCA2 mutation in 40% of patients(pts) with family history of breast cancer and 13% of those without such history. The presence of BRCA2 mutation has also been reported to be associated with 2 to 6-fold increase risk in prostate cancer. The aim of current study was to evaluate the association between cancers of the breast and prostate in men. Methods: We searched the Surveillance, Epidemiology and End Results Registry to identify male pts diagnosed with breast cancer (BC) between 1990 and 2012. Overall Survival (OS) was estimated using the Kaplan-Meier method and compared across groups using the log rank statistic. Cox models were then fitted to determine the association of an additional primary and OS after adjusting for patient and tumor characteristics. Results: Of 960373 pts with BC 6970 were male, representing 0.75% of the cohort, with a median age of 68 years. Of these, 2065 (30%) had more than one primary, 916 (13%) had BC as the first primary and 117 (5.6%) had contralateral BC. Among these men with BC, more than one primary was present in 26% of those of white/other race and 3.6% of black patients, respectively. Of the other primary cancers, the five most common (excluding contralateral BC) were prostate (n = 644, 31%), colorectal (n = 328,16%), lung (n = 205, 9.9%), urinary bladder (151, 7.3%) and melanoma (n = 107, 2.7%). Among 916 men in whom BC was the first primary, 245 (28%) subsequently developed prostate cancer at a median interval of 3 years (range 0 – 19 years) with 96% having moderate to high grade prostate tumors. At a median follow-up of 48 months for the whole cohort, the 5-year OS was 65%, being 67% and 60% in men who were white/other and black race, respectively (p < 0.0001) and 62% and 66% in men with and without more than one primary, respectively (p < 0.0001). In a Cox regression analysis the presence of additional primary was associated with an increased risk of death (HR = 1.12, 95% CI 1.03-1.31, p = 0.010) Conclusions: Male breast cancer is associated with other primary cancers in one-third of pts, most commonly with prostate cancer. These results have implications for evaluation of screening strategies and germline panel testing beyond that for BRCA, in these men.
Medicine must embrace technology to unleash benefits of science, says chief adviser
Authors: Zosia Kmietowicz
Journal: BMJ (2015)

“Something funny is going on” when it comes to using information technology in medicine, says Mark Walport, chief scientific adviser to the government. If the scepticism of the profession is not overcome, he warns, society will fail to reap the fruits that medical science can offer.

Walport made his comments during the Harveian Oration at the Royal College of Physicians on 15 October. The oration and dinner is given every year with proceeds from the estate of William Harvey, whose 1628 tome described the circulation of the blood and marked the beginning of clinical …
NS-14A PILOT STUDY OF USING MRI-GUIDED LASER HEAT ABLATION TO INDUCE DISRUPTION OF THE PERITUMORAL BLOOD BRAIN BARRIER TO ENHANCE DELIVERY AND EFFICACY OF TREATMENT OF PEDIATRIC BRAIN TUMORS
Authors: Karen Gauvain, David Tran, Joshua Rubin, Joshua Shimony, Jian Campian, Eric Leuthardt, David Limbrick
Journal: Neuro-Oncology (2016)
Correlation of Ki67 index (Ki67), mitotic count (MC) and phosphohistone-H3 (PHH3) grading and outcomes for gastrointestinal and pancreatic neuroendocrine tumors (GI NET/PNETs).
Authors: Kinsey McCormick, Antonios Papanicolau-Sengos, Claire Murphy, Sara Khor, Maria Westerhoff, Veena Shankaran
Journal: Journal of Clinical Oncology (2014)

e15153 Background: GI NET/PNETs are graded based on Ki67 or MC, as per the WHO. The rate of concordance in grade assignment of surgical specimens using these 2 methods is not well studied. We evaluated agreement in grade assignment of surgical GI NET/PNET specimens using MC and immunostaining for Ki67 and PHH3, a novel, mitosis-specific protein. Methods: This single-institution, retrospective study included pts with localized or metastatic PNET/GI NETs who underwent resection between 1999-2013 and had available specimens. Each tumor was assigned a grade using MC, Ki67 (as per the 2010 WHO classification system) and PHH3. PHH3 was determined by counting the number of PHH3-stained mitotic figures in 50 HPF (reported as # of positive cells/10 HPF), and grade was assigned using the same cutoffs as for MC. Clinical data were obtained from medical records and the US Death Index. Agreement in grade assignment was determined by weighted kappa statistic, and the survival rates at 3y and 5y, by grade, were compared using log-rank test. Results: Of the 126 pts (median age 53), 75 (60%) had GI NETs and 90 (71%) had local or regional disease. Discordance in grade assignment was 18% for Ki67 vs. MC, 37% for Ki67 vs. PHH3, and 30% for MC vs. PHH3 (κW0.36, 0.23 and 0.37, respectively). In general, grade assignments were higher by PHH3 than by Ki67 or MC. At a median follow up of 53 mo, median survival had not been reached. Survival rates at 3y and 5y were 95% and 87%, respectively. 3y and 5y survival did not differ between G1 and G2 by any grading method (Table). Conclusions: Ki67 and MC can provide conflicting information regarding tumor grade in pts with GI NET/PNETs. PHH3 tended to upgrade tumors, though standard cutoffs for this marker have not been established. Finally, the excellent survival of pts in this study challenges the clinical utility of distinguishing G1 from G2 tumors in a low risk population. Evaluation of the time investment and costs associated with each grading method should be considered. Survival rates at 3y, 5y according to grading method and grade. MC Ki67 PHH3 G1 G2 p-value G1 G2 p-value G1 G2 p-value 3y 96 89 0.46 96 93 0.54 95 96 0.74 5y 89 74 0.32 88 85 0.82 87 87 0.82
Studies on the Transmission of the Mouse Mammary Tumor Agent by the Male Parent
Authors: O. Mühlbock, M. D., Ph. D.
Journal: JNCI Journal of the National Cancer Institute (1952)

Studies on the Transmission of the Mouse Mammary Tumor Agent by the Male Parent Get access O. Mühlbock, M. D., Ph. D. O. Mühlbock, M. D., Ph. D. Laboratory of the Antoni van Leeuwenhoek-Huis, the Netherlands Cancer Institute, Amsterdam, Holland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 4, February 1952, Pages 819–837, https://doi.org/10.1093/jnci/12.4.819 Published: 01 February 1952 Article history Received: 09 October 1951 Published: 01 February 1952
Preservation of a Canine Thyroid Carcinoma in the Frozen State&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: M. W. Allam, L. S. Lombard, E. L. Stubbs, J. F. Shirer
Journal: JNCI Journal of the National Cancer Institute (1958)

Canine thyroid carcinoma cells from a transplanted tumor, when pre-conditioned in 5.3 percent dextrose and preserved at −60° to −70° C. according to the method of Craigie, were found to retain a high percentage of viability. Tumor tissue thus preserved for 16 months was tested in pre-treated puppies. Fifty percent of the injected animals developed tumors. No significant change was noted in the character of the tumor.
Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α
Authors: Zhiyu Dai, Ming Li, John Wharton, Maggie M. Zhu, You-Yang Zhao
Journal: Circulation (2016)

Vascular occlusion and complex plexiform lesions are hallmarks of the pathology of severe pulmonary arterial hypertension (PAH) in patients. However, the mechanisms of obliterative vascular remodeling remain elusive; hence, current therapies have not targeted the fundamental disease-modifying mechanisms and result in only modest improvement in morbidity and mortality.Mice with Tie2Cre-mediated disruption of Egln1 (encoding prolyl-4 hydroxylase 2 [PHD2]; Egln1(Tie2)) in endothelial cells and hematopoietic cells exhibited spontaneous severe PAH with extensive pulmonary vascular remodeling, including vascular occlusion and plexiform-like lesions, resembling the hallmarks of the pathology of clinical PAH. As seen in patients with idiopathic PAH, Egln1(Tie2) mice exhibited unprecedented right ventricular hypertrophy and failure and progressive mortality. Consistently, PHD2 expression was diminished in lung endothelial cells of obliterated pulmonary vessels in patients with idiopathic PAH. Genetic deletions of both Egln1 and Hif1a or Egln1 and Hif2a identified hypoxia-inducible factor-2α as the critical mediator of the severe PAH seen in Egln1(Tie2) mice. We also observed altered expression of many pulmonary hypertension-causing genes in Egln1(Tie2) lungs, which was normalized in Egln1(Tie2)/Hif2a(Tie2) lungs. PHD2-deficient endothelial cells promoted smooth muscle cell proliferation in part through hypoxia-inducible factor-2α-activated CXCL12 expression. Genetic deletion of Cxcl12 attenuated PAH in Egln1(Tie2) mice.These studies defined an unexpected role of PHD2 deficiency in the mechanisms of severe PAH and identified the first genetically modified mouse model with obliterative vascular remodeling and pathophysiology recapitulating clinical PAH. Thus, targeting PHD2/hypoxia-inducible factor-2α signaling is a promising strategy to reverse vascular remodeling for treatment of severe PAH.
The greening of the HMO: implications for prepaid psychiatry
Authors: M J Bennett
Journal: American Journal of Psychiatry (1988)

Over the past 15 years the health maintenance organization (HMO) movement has abandoned its social objectives in favor of economic ones. The early emphasis on making equitable and affordable health care available to populations has been superseded by concerns about profitability, market share, and consumer appeal. Psychiatric services, which came late in the HMO movement, were characterized by common values and priorities in the closed-panel HMOs of the 1970s. Trends toward independent practice associations (IPAs) and other open-panel systems, rising expectations, and the monetarization of health care are forcing prepaid psychiatrists to reassess their identity and roles.