tbuckley/cabot-search huggingface dataset:
Assessment of endometrial sampling as a predictor of final surgical pathology in endometrial cancer.
Authors: L. Helpman, R. Kupets, R. S. Saad, M. A. Khalifa, N. Ismiil, Z. Ghorab, V. Dube, S. Nofech-Mozes
Journal: Journal of Clinical Oncology (2010)

5072 Background: The histology and grade of endometrial cancer in hysterectomy specimens are important predictors of disease outcome. In most centers, however, surgical staging decisions are based upon the pre-operative biopsy specimen. The objective of this study is to assess the concordance between the histologic features of the preoperative biopsy and the hysterectomy specimen in endometrial cancer. Methods: Patients undergoing surgery for endometrial cancer during a 10 year period (1999- 2008) at a tertiary cancer centre were identified from a prospectively collected pathologic database. All pathology reports were reviewed to confirm centralized review of the original sampling or biopsy specimens; patients whose biopsies were not reviewed by a dedicated gynecologic pathologist at the treating centre were excluded. Surgical pathology data including histology, grade, depth of myometrial invasion, cervical involvement and lymphovascular space invasion (LVSI) as well as preoperative histology and grade were collected. Preoperative and final tumor grade were compared, and the incidence of high risk features were analyzed. Results: 1,062 consecutive patients were identified. 439 patients had central review of their original biopsies, and were included in this study. Of 252 patients whose biopsies were read as grade 1 adenocarcinoma, 46 (18%) were upgraded to grade 2 on final pathology and 6 (2%) were upgraded to grade 3. Moreover, 64 (25%) had deep myometrial invasion on final pathology, and a further 24 (10%) had other high-risk features (LVSI, cervical involvement or both). Of 114 grade 2 biopsies, 20 (18%) were upgraded to grade 3 on final pathology. A further 24 (21%) had deep myometrial invasion, and 20 (18%) had other high-risk features. Overall, at least 65 (18%) of 366 preoperatively defined low-grade cases would be classified as high risk on the basis of grade and myometrial invasion on final surgical pathology. Conclusions: Preoperative endometrial sampling is a only a modest predictor of surgical pathology features in endometrial cancer, and may therefore have a limited role in decisions regarding the extent of surgical staging. No significant financial relationships to disclose.
Small cell lung cancer
Authors: J. A. Hinson, M. C. Perry
Journal: CA A Cancer Journal for Clinicians (1993)

Small cell lung cancer is a unique form of lung cancer characterized by rapid growth, dissemination at diagnosis, and responsiveness to both radiotherapy and chemotherapy. It accounts for about one quarter of all lung cancers and, left untreated, results in the shortest survival of any pulmonary neoplasm, with a median survival of two to four months. This article reviews the epidemiology, pathology, clinical characteristics, staging, and treatment of this disease.
Physical Medicine and Rehabilitation
Authors: B Goldstein, M Hammond
Journal: JAMA (1997)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Patterns of Lymph Node Failure after Dose-escalated Radiotherapy: Implications for Extended Pelvic Lymph Node Coverage
Authors: Daniel E. Spratt, Hebert A. Vargas, Zachary S. Zumsteg, Jennifer S. Golia Pernicka, Joseph R. Osborne, Xin Pei, Michael J. Zelefsky
Journal: European Urology (2016)
The Stepwise Approach to Diabetes Prevention: Results From the D-CLIP Randomized Controlled Trial
Authors: Mary Beth Weber, Harish Ranjani, Lisa R. Staimez, Ranjit M. Anjana, Mohammed K. Ali, K.M. Venkat Narayan, Viswanathan Mohan
Journal: Diabetes Care (2016)

This study tests the effectiveness of expert guidelines for diabetes prevention: lifestyle intervention with addition of metformin, when required, among people with prediabetes.
Sex Differences in Tuberculosis Burden and Notifications in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis
Authors: Katherine C. Horton, Peter MacPherson, Rein M. G. J. Houben, Richard G. White, Elizabeth L. Corbett
Journal: PLoS Medicine (2016)

Background Tuberculosis (TB) case notification rates are usually higher in men than in women, but notification data are insufficient to measure sex differences in disease burden. This review set out to systematically investigate whether sex ratios in case notifications reflect differences in disease prevalence and to identify gaps in access to and/or utilisation of diagnostic services. Methods and Findings In accordance with the published protocol (CRD42015022163), TB prevalence surveys in nationally representative and sub-national adult populations (age ≥ 15 y) in low- and middle-income countries published between 1 January 1993 and 15 March 2016 were identified through searches of PubMed, Embase, Global Health, and the Cochrane Database of Systematic Reviews; review of abstracts; and correspondence with the World Health Organization. Random-effects meta-analyses examined male-to-female (M:F) ratios in TB prevalence and prevalence-to-notification (P:N) ratios for smear-positive TB. Meta-regression was done to identify factors associated with higher M:F ratios in prevalence and higher P:N ratios. Eighty-three publications describing 88 surveys with over 3.1 million participants in 28 countries were identified (36 surveys in Africa, three in the Americas, four in the Eastern Mediterranean, 28 in South-East Asia and 17 in the Western Pacific). Fifty-six surveys reported in 53 publications were included in quantitative analyses. Overall random-effects weighted M:F prevalence ratios were 2.21 (95% CI 1.92–2.54; 56 surveys) for bacteriologically positive TB and 2.51 (95% CI 2.07–3.04; 40 surveys) for smear-positive TB. M:F prevalence ratios were highest in South-East Asia and in surveys that did not require self-report of signs/symptoms in initial screening procedures. The summary random-effects weighted M:F ratio for P:N ratios was 1.55 (95% CI 1.25–1.91; 34 surveys). We intended to stratify the analyses by age, HIV status, and rural or urban setting; however, few studies reported such data. Conclusions TB prevalence is significantly higher among men than women in low- and middle-income countries, with strong evidence that men are disadvantaged in seeking and/or accessing TB care in many settings. Global strategies and national TB programmes should recognise men as an underserved high-risk group and improve men's access to diagnostic and screening services to reduce the overall burden of TB more effectively and ensure gender equity in TB care.
Breast-feeding: Time to Teach What We Preach
Authors: Lynn Todino
Journal: JAMA (1993)

<h3>To the Editor.</h3> —Thank you for the Special Communication by Freed.<sup>1</sup>As a registered nurse since 1963, a mother of two breast-fed children, and a natural childbirth educator, I have long lamented the lack of knowledge among health care professionals on this important subject. My obstetrician was all in favor of breast-feeding but did not offer any practical help. Fortunately, La Leche League's<i>The Womanly Art of Breastfeeding</i><sup>2</sup>came to the rescue. It still amazes me to hear new mothers tell of hospital experiences where their babies are taken away for hours after birth and are often given sugar water or formula before nursing can be established. Hurrah for Dr Freed! I hope his article will influence the medical community toward improving the sad state of knowledge in this vital area of health care.
Radiolabeled IL-2-Human Serum Albumin Fusion Protein (Albuleukin™) as a Potential New Reagent for Radioimmunoimaging / Therapy of Hodgkin’s Lymphoma.
Authors: Jan O. Staak, David Colcher, Jianyi Wang, Cynthia Sung, Andrew A. Raubitschek
Journal: Blood (2004)
Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive
Authors: Chad A. Newton, Kiran Batra, Jose Torrealba, Julia Kozlitina, Craig S. Glazer, Carlos Aravena, Keith Meyer, Ganesh Raghu, Harold R. Collard, Christine Kim Garcia
Journal: European Respiratory Journal (2016)

Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals. 115 patients with mutations in telomerase reverse transcriptase ( TERT ) (n=75), telomerase RNA component ( TERC ) (n=7), regulator of telomere elongation helicase 1 ( RTEL1 ) (n=14) and poly(A)-specific ribonuclease ( PARN ) (n=19) were identified and clinical data were analysed. Approximately one-half (46%) had a multidisciplinary diagnosis of idiopathic pulmonary fibrosis (IPF); others had unclassifiable lung fibrosis (20%), chronic hypersensitivity pneumonitis (12%), pleuroparenchymal fibroelastosis (10%), interstitial pneumonia with autoimmune features (7%), an idiopathic interstitial pneumonia (4%) and connective tissue disease-related interstitial fibrosis (3%). Discordant interstitial lung disease diagnoses were found in affected individuals from 80% of families. Patients with TERC mutations were diagnosed at an earlier age than those with PARN mutations (51±11 years versus 64±8 years; p=0.03) and had a higher incidence of haematological comorbidities. The mean rate of forced vital capacity decline was 300 mL·year −1 and the median time to death or transplant was 2.87 years. There was no significant difference in time to death or transplant for patients across gene mutation groups or for patients with a diagnosis of IPF versus a non-IPF diagnosis. Genetic mutations in telomere related genes lead to a variety of interstitial lung disease (ILD) diagnoses that are universally progressive.
Speed of Heart Rate Recovery in Response to Orthostatic Challenge
Authors: Cathal McCrory, Lisa F. Berkman, Hugh Nolan, Neil O’Leary, Margaret Foley, Rose Anne Kenny
Journal: Circulation Research (2016)

Rationale: Speed of heart rate recovery (HRR) may serve as an important biomarker of aging and mortality. Objective: To examine whether the speed of HRR after an orthostatic maneuver (ie, active stand from supine position) predicts mortality. Methods and Results: A longitudinal cohort study involving a nationally representative sample of community-dwelling older individuals aged ≥50 years. A total of 4475 participants completed an active stand at baseline as part of a detailed clinic-based cardiovascular assessment. Beat-to-beat heart rate and blood pressure responses to standing were measured during a 2-minute window using a finometer and binned in 10-s intervals. We modeled HRR to the stand by age group, cardiovascular disease burden, and mortality status using a random effects model. Mortality status during a mean follow-up duration of 4.3 years served as the primary end point (n=138). Speed of HRR in the immediate 20 s after standing was a strong predictor of mortality. A 1-bpm slower HRR between 10 and 20 s after standing increased the hazard of mortality by 6% controlling for established risk factors. A clear dose–response relationship was evident. Sixty-nine participants in the slowest HRR quartile died during the observation period compared with 14 participants in the fastest HRR quartile. Participants in the slowest recovery quartile were 2.3× more likely to die compared with those in the fastest recovery quartile. Conclusions: Speed of orthostatic HRR predicts mortality and may aid clinical decision making. Attenuated orthostatic HRR may reflect dysregulation of the parasympathetic branch of the autonomic nervous system.
The Royal College of Physicians of London. Portraits.
Authors: G. E. W. Wolstenholme, David Piper
Journal: Annals of Internal Medicine (1964)

Reviewsbutryaceous fluid is very often present, which rising to the top of its serum, in conjunction with the caseous-like principle of which we have been speaking, forms an appearance exactly resembling the cream of milk; and these principles are often so abundant, especially in the chyle of animals fed on flesh, that, as Dr. Marcet has observed, they may be readily detected, even in the blood itself.Vauquelin remarked the near resemblance of this fatty matter to that which he had extracted from the brain, and I made the same remark before I had seen Vauquelin's paper.....1 It may prove possible to identify other reviews as Elliotson's, for books on animal magnetism and the doctrines of Gall and Spurzheim were analysed.
Frequency and predictors of response to outpatient palliative care in patients with moderate to severe cancer pain.
Authors: J. H. Kang, S. Yennurajalingam, G. Chisholm, S. H. Kim, W. Rhondali, D. Hui, E. Bruera
Journal: Journal of Clinical Oncology (2011)

e19698 Background: Pts with advanced cancer frequently suffer from uncontrolled pain. Response rate is an important clinical and quality of care outcome in most guidelines. The primary aim of this study is to determine frequency and predictors associated with pain response to state of the art palliative care. Methods: Consecutive pts with advanced cancer with moderate to severe pain presenting in the Supportive care clinic with a complete Edmonton symptom assessment scale (ESAS) at initial and subsequent visit were reviewed. All pts received interdisciplinary care led by palliative care specialists (IDT) following common care pathways. A logistic regression model to determine if baseline demographics, primary cancer type, ESAS, Memorial Delirium assessment scale, and CAGE (screening for alcoholism), were associated with response (defined as ≥2 points reduction in pain intensity). Results: 1150 pts (median age 60; male/female ratio 0.98) were included. Median time between initial and follow-up visit 15 days. The mean (SD), median baseline pain was 6.8 (1.9) and 7. Overall 598/1150 patients (52%) had a response. 411/639 (64%) of pts with pain ≥7/10 (severe pain group) at baseline had response compared to 187/511 (37%) of pts with moderate pain (4-6/10), (p<0.0001), however 217/639(34%) of the severe pain group had pain improved to ≤ 3/10 (mild pain) as compared to 170/511(33%) in moderate pain group (p=0.07). Fatigue (r=0.22, p<0.01), depression (r=0.14, <0.01), anxiety (r=0.16, p<0.01), sleep (r=0.15, p<0.01), and feeling of wellbeing (r=0.14, p<0.01), appetite (r=0.14, p<0.01), nausea (r=0.18, p<0.01) are associated with pain at initial consult. Factors associated with response to pain were baseline pain (OR, 1.4 per point; p<0.01), fatigue (OR, 1.01 per point; p=0.014) and ESAS symptom burden (OR, 1.01 per point; p=0.039). However, delirium (p=0.50), alcoholism (p=0.19), depression (p=0.35), anxiety (p=0.25), sleep (p=0.16) did not show significant association with pain response. Conclusions: Current response criteria have more false positive results in severe pain group. Pts with severe pain needs more frequent and aggressive IDT. Further studies are warranted.
A Wild Rotation
Authors: Gilad D. Evrony
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Therapy for Low High-Density Lipoprotein Cholesterol in the Face of 'Desirable' Levels of Total Cholesterol-Reply
Authors: Gloria Lean Vega
Journal: JAMA (1990)

<h3>In Reply. —</h3> Dr Miller points out that our definition of normolipidemia included total cholesterol levels below 6.47 mmol/L and was not restricted to levels below 5.2 mmol/L, which have been called "desirable" cholesterol levels by the National Cholesterol Education Program. He suggests that our findings for the latter category would be of interest. In response, our patient group included 13 patients in whom total cholesterol levels were in the desirable range (&lt;5.2 mmol/L) at the time of entry into the study. The results for these patients are summarized in the Table. The direction and magnitudes of changes were similar for those with cholesterol levels below 5.20 mmol/L and for the whole group with levels below 6.47 mmol/L. Therefore, it appears that the conclusions drawn for the whole group can be extended to patients with low high-density lipoprotein cholesterol levels in whom total cholesterol levels are in the desirable range,
Antitumor activity of ZD6474, a small molecule VEGF receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to EGF receptor-targeted drugs.
Authors: F Ciardiello, R Bianco, R Caputo, Damiano, B Veneziani, F De Vita, S De Placido, Ar Bianco, G. Tortora
Journal: Journal of Clinical Oncology (2003)
UK drug appraisal process is restricting access to cancer drugs, say charities
Authors: Jacqui Wise
Journal: BMJ (2016)

NHS patients are being denied access to innovative new cancer treatments while other similar countries find ways to make them available, a report by two charities, Breast Cancer Now and Prostate Cancer UK, has found.1 The document has called for reform of the system that assesses new drugs to allow price negotiation.

The report reviewed the drug appraisal systems and the availability of breast and prostate cancer drugs in England, Scotland, Wales, Germany, France, Australia, Canada, and Sweden. It concluded that while no system was perfect there were aspects of other health systems that could be potentially implemented in the United Kingdom to improve levels of access.

The National Institute for Health and Care Excellence in England and Wales, and the Scottish Medicines Consortium in Scotland, assess new …
Abstract 16152: Influence of Hospital Characteristics and Operator Volume on Adverse Outcomes of Atrial Fibrillation Ablation
Authors: Juan F Viles-Gonzalez, Abhishek Deshmukh, Apurva O Badheka, Ankit Chothani, Neeraj Shah, Nileshkumar J Patel, Peeyush Grover, Ghanshyambhai T Savani, Kathan Mehta, Vikas Singh, Ankit Rathod, Luigi Di Biase, Andrea Natale, James O Coffey, Hakan Paydak
Journal: Circulation (2013)

Background: Utilization of Atrial Fibrillation (AF) ablation has grown exponentially over the last decade motivated by clinical trials demonstrating efficacy and safety of the procedure. Results reported by selected academic centers or operators with extensive expertise in catheter ablation may not be attained outside the context of a clinical trial. The aim of our study was to examine the impact of hospital characteristics and operator experience on in-hospital complications due to AF ablation.

Methods: Using the Nationwide Inpatient Sample (NIS) we assessed AF ablations between 2000-2010. We investigated in-hospital complications including pericardial tamponade, stroke, transient ischemic attack, vascular access complications and death. We stratified hospitals by its bed size, location, teaching status, region of the country and the annual AF ablation volume as more than 100, between 50-100, and less than 50. We divided annual operator volume as more than 50 procedures, between 50-25 and less than 25.

Results: 93801 AF ablations were identified between the years 2000-2010. The overall frequency of complications was 6.29%. Most procedures were performed in hospitals which were large (79%), urban (98.1%), academic (70.8%) and located in south (31.6%). 68.2% of the procedures were performed in low volume (<50 annual procedures) hospitals and 81% of procedures were performed by operators doing less than 25 AF ablations a year. On creating multiple models for independent predictors of complications, the hospital volume and operator volume were significantly associated with higher in-hospital complications (Table).

Conclusion: In the largest sample of AF ablations reported thus far, we found a significant association between operator and hospital volume on adverse outcomes. This suggests a need for future research into defining competency for this ablation procedure, and instituting appropriate interventions to improve overall AF ablation outcomes.

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Recipient's genetic R702W NOD2 variant is associated with an increased risk of bacterial infections after orthothopic liver transplantation
Authors: Bert-Jan de Rooij, Marcel Janse, Bart van Hoek, Robert J. Porte, Minneke J. Coenraad, Bouke G. Hepkema, Hein W. Verspaget, Rinse K. Weersma
Journal: Hepatology (2012)
Cervical Cancer Screening Among Women Without a Cervix
Journal: JAMA (2004)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal