tbuckley/cabot-search huggingface dataset:
A Case-Control Study of Hodgkin's Disease in Israel&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Abramson, J. H., Pridan, H., Sacks, M. I., Avitzour, M., Peritz, E.
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article A Case-Control Study of Hodgkin's Disease in Israel Get access J. H. Abramson, J. H. Abramson 3Department of Social Medicine, Hebrew University-Hadassah Medical School, P.O. Box 1172, Jerusalem, Israel.4Established Investigator of the Chief Scientist's Bureau, Ministry of Health, Israel. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Pridan, H. Pridan 3Department of Social Medicine, Hebrew University-Hadassah Medical School, P.O. Box 1172, Jerusalem, Israel. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. I. Sacks, M. I. Sacks 5Department of Pathology, Soroka Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheba, Israel. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Avitzour, M. Avitzour 3Department of Social Medicine, Hebrew University-Hadassah Medical School, P.O. Box 1172, Jerusalem, Israel. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Peritz E. Peritz 3Department of Social Medicine, Hebrew University-Hadassah Medical School, P.O. Box 1172, Jerusalem, Israel. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 61, Issue 2, August 1978, Pages 307–314, https://doi.org/10.1093/jnci/61.2.307 Published: 01 August 1978 Article history Received: 14 September 1977 Accepted: 25 February 1978 Published: 01 August 1978
Establishment and erythroid differentiation of a cytokine-dependent human leukemic cell line F-36: a parental line requiring granulocyte- macrophage colony-stimulating factor or interleukin-3, and a subline requiring erythropoietin
Authors: S Chiba, F Takaku, T Tange, K Shibuya, C Misawa, K Sasaki, K Miyagawa, Y Yazaki, H Hirai
Journal: Blood (1991)
DSM-IV: work in progress
Authors: A Frances, H A Pincus, T A Widiger, W W Davis, M B First
Journal: American Journal of Psychiatry (1990)

The authors present an overview of the work in progress on DSM-IV. After a brief historical review, they discuss the principles and multiple purposes of the DSM-IV effort and outline the three stages of its empirical documentation: systematic literature reviews, analysis of unpublished data, and field trials. Next, they discuss several of the basic conceptual issues that are implicit in revising a nomenclature. These include the definition of mental disorder, the balance between multiple diagnosis and differential diagnosis, the use of categorical and dimensional models of classification, and issues involved in the construction of criteria. Finally, they summarize the most important specific questions being reviewed by each of the DSM-IV work groups.
Two memorable patients: Two nil
Authors: Joanne Banks
Journal: BMJ (2004)

It is a dull wet Saturday afternoon in Goodison Park. The fans are filing in, and there is a tense excited atmosphere around the ground. It is nearing the end of the season, and everyone is hoping the seemingly inevitable relegation battle can be avoided this year. The Goodison faithful are buzzing with the prospect of taking three points from fellow strugglers. Behind the scenes, the usual band of St John Ambulance volunteers have gathered—doctors, nurses, firemen, policemen, dockers, students, and others from all walks of life.

As the match enters the last five minutes, the only thought echoing around the ground is how to put the ball into the goal. Until, that is, a simple radio message is received: “Code Blue, cardiac arrest in the Lower Bullens stand.”

Our team jumps into action. We arrive to find an unresponsive, cyanotic, elderly man stretched out across four seats. Cardiopulmonary resuscitation is already being performed by a dockworker; he's an experienced first aider. Other members of our team and the club doctor arrive with oxygen and an automatic defibrillator. The casualty is in ventricular fibrillation, and the first three shocks are given immediately, but with no effect. We intubate and cannulate him, as slick as any hospital arrest team. A fourth shock is given, and we get a result—the rhythm change that everyone is looking for. A spontaneous circulation is returned.

Just as we all relax, lightning strikes twice: “Code Blue, cardiac arrest in the Gwladys Street stand.” Half our team go tearing off to the second incident, with the match now in injury time. A second unresponsive man is found in cardiac arrest, but not for long. We are joined by an ambulance service team and soon once more have a spontaneous output.

The crowd are now filing out, blissfully unaware as two paramedic vehicles arrive. The first man has spat out his endotracheal tube and is conscious, asking what the score is. Two live casualties are taken to hospital. Our team of volunteers returns to the first aid point buzzing, but football and relegation are no longer important. The only score on everyone's mind now is St John 2—Undertakers 0.

Working in a state of the art hospital surrounded by machines that go beep and staff who have trained in their professions for many years can sometimes make us forget the basics. It is humbling to remember that the two lives saved that day weren't due to fancy new techniques or expensive modern technology. They were saved by a group of volunteers, the likes of whom may be found at every major sporting event and public gathering across the country.
The Complement System of Man
Authors: Shaun Ruddy, Irma Gigli, K. Frank Austen
Journal: New England Journal of Medicine (1972)

Phylogeny, Ontogeny and BiologyPhylogenyThe nine components of the classic hemolytic complement system and certain proteins of the alternate pathway have been recognized in terms of both physicochemical and functional characteristics in man.4 In lower species the knowledge of the complement system is less complete,34,59 but functional data concerning the classic and alternate pathways are sufficient to permit a preliminary analysis of the phylogenetic development of this system.60Invertebrates. Studies of complement available in invertebrate species include representatives of the arthropoda (horseshoe crab), sipunculoidea (sipunculid worm), and echinodermata (starfish). No lytic activity has been demonstrated in the hemolymph of . . .
Premorbid sociosexual functioning and long-term outcome in schizophrenia
Authors: R S Keefe, R C Mohs, M F Losonczy, M Davidson, J M Silverman, T B Horvath, K L Davis
Journal: American Journal of Psychiatry (1989)

Chronic schizophrenic patients with the most severe social deterioration have been shown to differ from other chronic schizophrenic patients with respect to measures of left-to-right ventricular asymmetry, negative symptoms, and response to haloperidol treatment. In the current study, the authors investigated the social antecedents of these characteristics of very poor outcome schizophrenia in 69 chronic schizophrenic patients. Poor premorbid sociosexual functioning was associated with more severe left-to-right ventricular asymmetry, greater severity of negative symptoms, fewer positive symptoms, and worse current social functioning. These data suggest that factors associated with severe social deterioration in the end stage of schizophrenia are also associated with premorbid sociosexual impairment.
Conceptual and methodological issues in comparative studies of psychotherapy and pharmacotherapy, I: Active ingredients and mechanisms of change
Authors: I Elkin, P A Pilkonis, J P Docherty, S M Sotsky
Journal: American Journal of Psychiatry (1988)

There has recently been an increased focus on comparing the effectiveness of drugs and psychotherapy in the treatment of mental disorders. The marked differences between these two treatment forms raise many conceptual and methodological problems for the investigator. In a two-part series, the authors discuss a number of these conceptual issues and their implications for research design, implementation, and interpretation of findings. Part I focuses on differences in the active ingredients and hypothesized mechanisms of change of psychotherapy and pharmacotherapy. Issues addressed include the need for standardization of treatments, adequate delivery of treatments, and controlling for factors other than the active ingredients of each treatment.
PTH-159 The relevance of lymph node metastases in the proximal field of the chest in patients with adenocarcinoma of the gastro-oesophageal junction treated with neoadjuvant therapy followed by transthoracic oesophagectomy
Authors: SM Lagarde, VP Jagadesham, SS Gisbertz, A Immanuel, M van Berge Henegouwen, M Griffin
Journal: Gut (2015)

<h3>Introduction</h3> The prognosis of gastroesophageal junction adenocarcinoma is unquestionably related to the extent of nodal involvement. Not only the amount of positive lymph nodes but also the location of postive nodes negatively influence survival. Earlier small studies revealed a poor survival for patients with positive nodes in the proximal field of the chest when treated with surgery alone. It is thus far unknown what the relevance of these nodes is after neoadjuvant therapy. The aim of the present study was to identify the incidence and prognostic significance of lymph node metastases in the proximal part of the chest in patients who underwent a transthoracic oesophagectomy after neoadjuvant therapy. <h3>Method</h3> From a prospectively collected database, a consecutive series of patients in two high volume centres in Europe was analysed. All patients with potentially curable adeno carcinoma of the gastro-oesophageal junction were treated with neoadjuvant chemo (radiation)therapy therapy followed by transthoracic oesophagectomy and two-field lymphadenectomy. <h3>Results</h3> Between January 2000 and September 2013 a consecutive series of 208 patients underwent an oesophagectomy after neoadjuvant therapy for adenocarcinoma of the gastro-oesophageal junction. 80 (38.5%) patients had no evidence of lymph node metastases (N0). There were 128 patients (61.5%) with positive nodes (N1=41 (19.7%), N2=44 (21.2%), N3=43 (20.7%)). Of the node positive patients, 25 (19.5%) had positive nodes in the proximal field of the chest (paratracheal, subcarinal, bronchial and aorto-pulmonary window lymph nodes). More advanced N-stage was significantly associated with positive nodes in the proximal field of the chest (p &lt; 0.001). Median survival was significantly (p = 0.003) worse for patients with positive nodes in the proximal part of the chest (12.4 months (95% CI: 11.4–13.32)) compared with patients with positive nodes on other locations (28.3 months (95% CI: 22.7–33.9)). <h3>Conclusion</h3> Lymph node metastases in the proximal part of the chest in patients is a common phenomonemon and a sign of advanced disease. Radical surgical resection can only be achieved with an extended transthoracic resection. Even after neoadjuvant therapy followed by transthoracic resection long-term survival is poor. <h3>Disclosure of interest</h3> None Declared.
Thin films as an emerging platform for drug delivery
Authors: Sandeep Karki, Hyeongmin Kim, Seon-Jeong Na, Dohyun Shin, Kanghee Jo, Jaehwi Lee
Journal: Asian Journal of Pharmaceutical Sciences (2016)

Pharmaceutical scientists throughout the world are trying to explore thin films as a novel drug delivery tool. Thin films have been identified as an alternative approach to conventional dosage forms. The thin films are considered to be convenient to swallow, self-administrable, and fast dissolving dosage form, all of which make it as a versatile platform for drug delivery. This delivery system has been used for both systemic and local action via several routes such as oral, buccal, sublingual, ocular, and transdermal routes. The design of efficient thin films requires a comprehensive knowledge of the pharmacological and pharmaceutical properties of drugs and polymers along with an appropriate selection of manufacturing processes. Therefore, the aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design. It also highlights the recent trends and perspectives to develop thin film products by various companies.
Failure to find evidence of schizophrenia in first-degree relatives of schizophrenic probands
Authors: H G Pope, J M Jonas, B M Cohen, J F Lipinski
Journal: American Journal of Psychiatry (1982)

The first-degree relatives (N = 199) of DSM-III schizophrenic probands (N = 39) were diagnosed from chart data by a rater who was blind to proband diagnosis. No cases of even "possible" schizophrenia were found. This augments the growing evidence that the genetic component in schizophrenia may be less than was formerly suspected.
SAT0344 The Association Between Cumulative Glucocorticoid Exposure and Glucocorticoid-Related Adverse Events Among Patients with Rheumatoid Arthritis: A US Database Analysis
Authors: J.H. Best, A. Farr, K. Sarsour, M. Stott-Miller, Y. Hwang
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Oral glucocorticoids (OGCs) are commonly used to treat inflammation associated with rheumatoid arthritis (RA). The appropriate duration of use and dose is debated because of the adverse event (AE) profile of OGCs. <h3>Objectives</h3> To evaluate the associations between cumulative doses of OGCs and OGC-related AEs among patients with RA. <h3>Methods</h3> RA patients 18 years of age and older were selected from a large US administrative claims database based on the presence of ≥2 claims with a diagnosis code for RA in 2012. RA patients were required to be continuously enrolled in the database from January 1, 2012, to December 31, 2012 (baseline period) and from January 1, 2013, to December 31, 2013 (evaluation period) and could not have received a diagnosis for another autoimmune condition. Cumulative OGC dose was measured in outpatient pharmacy claims during the baseline period. The presence of an OGC-related AE (diagnosis of osteoporosis, bone fracture, aseptic necrosis of the bone, cataract, diabetes, or ulcer/gastrointestinal hemorrhage in the inpatient or outpatient setting or diagnosis of pneumonia, opportunistic infection, myocardial infarction, or stroke during an inpatient admission) was assessed during the evaluation period. Multivariable logistic regression models were fitted to compare odds of OGC-related AEs across levels of cumulative doses of OGC, controlling for patient demographic and clinical characteristics. Models were stratified by use of disease-modifying antirheumatic drugs in the baseline period. <h3>Results</h3> The sample was composed of 84,357 RA patients; mean age was 59 years, and 76% were female; 48% used OGCs during the baseline period, with a mean cumulative dose of 1,334 mg (median, 770 mg). During the follow-up period, 22,207 patients (26%) had an OGC-related AE. The most common AEs were cataract, bone fracture, and osteoporosis. Table 1 displays the number of patients with an AE for each OGC dose cohort and the adjusted odds ratio for AEs (95% CI), with the no-OGC use cohort as the reference group. <h3>Conclusions</h3> Among RA patients, those with a cumulative OGC dose of &gt;1,800 mg during a 12-month period generally had a greater probability of experiencing an OGC-related AE during the following year. A cumulative dose between &gt;800 and 1,800 mg was associated with an increased probability of bone fracture and osteoporosis. <h3>Disclosure of Interest</h3> J. Best Employee of: Genentech, A. Farr Consultant for: Genentech, K. Sarsour Employee of: Genentech, M. Stott-Miller Consultant for: Genentech, Y. Hwang: None declared
Development and internal validation of a nomogram for prediction of prostate cancer specific survival 2, 5, 10, 15, 20 and 25 years after radical prostatectomy
Authors: C. R. Porter, K. Kodama, R. Gibbons, R. Correa, P. Perrotte, P. Karakiewicz
Journal: Journal of Clinical Oncology (2005)

4652 Introduction: Accurate prediction of prostate cancer specific survival (PCa-NED) after Radical Prostatectomy (RP) is difficult due to limited availability of data with adequate follow-up. We present PCa-NED data and prognostic nomograms for PCa-NED based on a large, single center cohort treated with RP. Methods: 798 consecutive men were treated at Virginia Mason Medical Center, Seattle, WA. by 2 principle surgeons between 12/1954–5/1994, by RP for clinically localized prostate cancer (PCa): 4 received neadjuvant hormomal ablation and 11 were lost to follow-up. Therefore,a cohort of 779 men was used in this analysis. Age at surgery ranged from 43–78 years (median 64). The pathologic stages were T2a:177 (22.8%); T2b:234 (30.1%); T3a:244 (31.4%);T3b:97 (12.5%); T3c:16 (2.1%), and N1:10 (1.3%). Pathologic Gleason sums were 2:3 (0.4%); 3:20(2.6%); 4:51(6.6%); 5:150(19.3%); 6:304(39.1%); 7:180(23.1%); 8: 42(5.4%); 9:25(3.2%); and 10:3(0.4%). Kaplan-Meier and multivariate Cox regression models were used to test the association between age at surgery, pathologic stage, and pathologic grade and outcome defined by PCa-NED. Cox regression coefficients were then used to develop a PCa-NED nomogram. To reduce overfit bias and for internal validation, the nomogram was subjected to 200 bootstrap resamples. Results: Mean and median follow-ups were respectively 139 and 137 months (range 0–486). Overall, 54 (6.9%) of men died of PCa. The 60, 120, 180, 240, and 300 months actuarial PCa-NED rates were respectively 98.9% (97.8–99.4), 95.6% (93.6–96.9), 90.2% (86.8–92.7), 86.1% (81.2–89.9), and 82.2 (74.1–87.9). Median PCa-NED was not reached. In Cox models, pathologic stage (p<0.001), and pathologic Gleason sum (p=0.015) represented significant predictors. Bootstrap-corrected predictive accuracy of the PCa-NED nomogram was 0.738. Conclusion: Excellent long-term Pca survival outcomes may be expected after RP for localized Pca: these can be highly accurately predicted (74%), and used for counseling, follow-up, or treatment. No significant financial relationships to disclose.
Hemorrhagic Disease and Unusual Hepatic Lesions Associated with Intracerebral Passage of Rous Sarcoma Virus in Chicks&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Vincent Groupé, Frank J. Rauscher, W. Ray Bryan
Journal: JNCI Journal of the National Cancer Institute (1957)

Hemorrhagic Disease and Unusual Hepatic Lesions Associated with Intracerebral Passage of Rous Sarcoma Virus in Chicks Vincent Groupé, Vincent Groupé Institute of Microbiology, Rutgers University, The State University, New Brunswick, New Jersey, and National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank J. Rauscher, Frank J. Rauscher Institute of Microbiology, Rutgers University, The State University, New Brunswick, New Jersey, and National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Ray Bryan W. Ray Bryan Institute of Microbiology, Rutgers University, The State University, New Brunswick, New Jersey, and National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 1, July 1957, Pages 37–47, https://doi.org/10.1093/jnci/19.1.37 Published: 01 July 1957 Article history Received: 02 April 1957 Published: 01 July 1957
Nosocomial transmission of measles among healthcare workers, Bulgaria, 2010
Authors: R Komitova, A Kunchev, Z Mihneva, L Marinova
Journal: Eurosurveillance (2011)

This report describes 326 cases of nosocomial transmission of measles with 286 cases among non-healthcare workers who acquired the disease in a hospital setting. Between October 2009 and April 2010, 40 healthcare workers from seven different regions in Bulgaria have contracted the disease.
PTU-041 Colonoscopic perforations in the english nhs bowel cancer screening programme (nhsbcsp)
Authors: E Derbyshire, C Nickerson, A Hungin, MD Rutter
Journal: Gut (2015)

<h3>Introduction</h3> Colonoscopic perforation remains one of the most serious adverse events associated with colonoscopy. Colonoscopies in the English NHSBCSP are performed at 61 Screening Centres. There is a robust system for capturing the details of adverse events; patients are contacted at 24 h and 30 days post procedure, Centres complete an adverse event form, reviewed by regional Quality Assurance leads, and event details are entered onto a national web based database, the Bowel Cancer Screening System (BCSS). We have previously reported an NHSBCSP perforation rate of 0.06%, and risk factors for perforation.<sup>1</sup> This study aimed to (1) describe perforation presentation, management and outcomes, and (2) determine perforation morbidity and mortality rates. <h3>Method</h3> We identified all reported colonoscopic perforations from the start of the NHSBCSP in 2006 up to 13/03/2014. The NHSBCSP defines perforation as: air, luminal contents or instrumentation outside the gastrointestinal tract. BCSS was interrogated to identify patient and procedure details. Centres completed a detailed online questionnaire on presentation, management and outcome. <h3>Results</h3> Of 147 perforations identified, complete data on 117 was recieved. 58.1% were male, mean age was 65.5. 69.2% were therapeutic perforations. The endoscopist visualised the perforation in 12.8% of cases (median perforation size 5 mm) applying endoclips in 80% of these. 54.5% of diagnostic perforations were in the sigmoid colon. Of 115 patients admitted to hospital, 31.3% were admitted immediately following colonoscopy, 67% represented with abdominal pain having been discharged, 1.7% were recalled following radiological investigation. 54.8% had surgery including 86.4% of diagnostic and 45.7% of therapeutic perforations. 26.1% (47.6% of those who had surgery) were left with a stoma. Post Perforation Morbidity defined as an in-patient complication or new diagnosis was 19.7%. Median hospital stay was 9.5 days (range 0–51 days). 25.2% were admitted to the Intensive Care Unit. The mortality rate was 0.87%. <h3>Conclusion</h3> This is the largest case series reporting outcomes after colonoscopic perforation in the UK. The colonoscopist recognised the perforation during colonoscopy in only 12.8% of cases, the majority representing with abdominal pain after a mean of 2 days. 44.3% of perforations admitted were successfully managed conseravtively including 13.6% of diagnostic and 53.1% of therapeutic perforations. Over a quarter of perforations admitted are likely to leave hospital with a stoma. A post perforation morbidity rate of 19.7% and mortality rate of 0.87% compares favourably with other series. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Rutter MD, <i>et al</i>. Endoscopy 2014:90–97