tbuckley/cabot-search huggingface dataset:
Impaired Hydroxylation of 5-Methylcytosine In TET2 mutated Patients with Myeloid Malignancies
Authors: Anna Jankowska, Myunggon Ko, Yun Huang (equal contribution), Utz J. Pape, Hadrian Szpurka, Mamta Tahiliani, Hozefa S. Bandukwala, Jungeun An, Edward D. Lamperti, Kian Peng Koh, X. Shirley Liu, L. Aravind, Suneet Agarwal, Anjana Rao, Jaroslaw P Maciejewski
Journal: Blood (2010)
Meta-Analysis of the Efficacy and Safety of Bortezomib Retreatment in Patients with Multiple Myeloma (MM)
Authors: Kevin B Knopf, Mei Sheng Duh, Marie-Hélène Lafeuille, Jonathan Gravel, Patrick Lefebvre, Liviu Niculescu, Abbie Ba-Mancini, Esprit Ma, Hongliang Shi, Raymond L. Comenzo
Journal: Blood (2012)
Preclinical and Clinical Pharmacodynamics of Pan-Pim Inhibition By AZD1208 in Acute Myeloid Leukemia: Assessment of Pim Isoform Dependency for Bad and 4EBP1 Phosphorylation
Authors: Kristen A McEachern, Adriana E Tron, Greg O'Connor, Rachel DuPont, Francis D Gibbons, Lourdes Pablo, Karthick Vishwanathan, Patricia McCoon, Jorge E. Cortes, Daniel J. DeAngelo, Mark D Minden, Geoffrey L. Uy, Frank Neumann, Karen Keating, Dennis Huszar, J. Elizabeth Pease, Jeffrey Brown, J. Carl Barrett
Journal: Blood (2014)
Reduced-Intensity Conditioning (RIC) Allogeneic Stem Cell Transplantation (allo-SCT) for Patients Aged ≥60 Years: a Retrospective Study of 629 Patients From the Societe Française De Greffe De Moelle Et De Therapie Cellulaire (SFGM-TC).
Authors: Patrice Chevallier, Didier Blaise, Noel-Jean Milpied, Mauricette Michallet, Jean-Paul Vernant, Nathalie Fegueux, Marc Renaud, Bernard Rio, Nicole Gratecos, Jean-Yves Cahn, Gerard Socie, Ibrahim Yakoub-Agha, Anne Huynh, Sylvie Francois, Jacques-Olivier Bay, Catherine Cordonnier, Agnes Buzyn, Nathalie Contentin, Eric Deconinck, Mohamad Mohty
Journal: Blood (2009)
Scientific Evidence and Financial Obligations to Ensure Access to Biosimilars for Cancer Treatment
Authors: Howard Bauchner, Phil B. Fontanarosa, Robert M. Golub
Journal: JAMA (2016)

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Increased Expression of Cyclin A1 mRNA Is a Novel Adverse Prognostic Indicator for Acute Promyelocytic Leukemia in Differentiation Therapy by All-Trans Retinoic Acid.
Authors: Tsuyoshi Nakamaki, Hidetoshi Nakashima, Masamichi Hattori, Takako Usui, Mayumi Honma, Daisuke Adachi, Bungo Saito, Shigeru Tomoyasu
Journal: Blood (2006)
Case 32-1978
Authors: Stephen C. Schoenbaum, Eugene J. Mark
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 31-year-old man was admitted to the hospital because of respiratory failure.He was well until three weeks previously, when he began to have abdominal pain. One week later fever, vomiting and a cough productive of blood-streaked, brownish sputum developed. He also complained of a sore throat and chest pain on deep breathing. Thirteen days before admission he entered another hospital because of fever, confusion, weakness and respiratory distress. An x-ray film of the chest revealed a homogeneous opacification of the left-lower-lung field. Proteinuria was found. Cultures of blood, sputum and urine yielded no pathogenic micro-organisms. Penicillin, . . .
Safety and Efficacy of New Nonacog Alfa Drug (Innonafactor) in Prophylactic Treatment in Patients with Severe and Moderate Hemophilia B
Authors: Tatiana Andreeva, Vladimir Yu. Zorenko, Igor Davydkin, Valeria Konstantinova, Olga Zalepukhina, Nina Klimova, Georgy Mishin, Igor Kurtov, Maria Shamina, Elena Fatenkova, Olga Gusyakova, Alexandr Shuster, Dmitry Kudlay, Sergey Lukyanov, Anton Borozinets, Eugene Nikitin, Ekaterina Klykova
Journal: Blood (2015)
Cyclin D1 Over-Expressing Mantle Cell Lymphoma Cells Are Hypersensitive to Inhibition of Fatty Acid Synthase (FASN)
Authors: Michael A. Dengler, Matthias Gutekunst, Stephanie Kopacz, Heike Horn, Ute Hofmann, Matthias Schwab, German Ott, Heiko van der Kuip, Walter E. Aulitzky
Journal: Blood (2011)
Evaluation of CD52 Expression in Hematopoietic Neoplasms by Standard Immunohistochemistry: Implications for the Expanded Use of Alemtuzumab (CAMPATH-1H) in the Treatment of Hematological Malignancies.
Authors: Scott J. Rodig, Jeremy S. Abramson, Geraldine S. Pinkus, Steven P. Treon, Margaret A. Shipp, Jeffery L. Kutok
Journal: Blood (2005)
Prognostic Impact of High Hematogones in Acute Myeloid Leukemia
Authors: Dulcineia Pereira, Sergio Pereira Chacim, Edgar Mesquita, Ana Espirito-Santo, Ilidia Moreira, Nelson Domingues, Isabel Oliveira, Luísa Viterbo, Margarida Marques, Carlos Palmeira, Maria Emília Sousa, Inês Godinho, Ana Marta Pires, Nuno Cerveira, Susana Bizarro, Manuel R. Teixeira, Ângelo Martins, Gabriela Martins, Jose Mario Mariz
Journal: Blood (2012)
Anti-CD20-Interferon-α Fusion Protein Demonstrates Potent Direct Growth Inhibition, Antibody-Dependent Cellular Cytotoxicity, and Enhanced Complement-Dependent Cytotoxicity Against Human B Cell Lymphomas In Vitro, and Activity Against Multiple Human NHL Xenografts In Vivo
Authors: Reiko E Yamada, Kristopher K Steward, Gataree Ngarmchamnanrith, Sanjay Khare, Raj Sachdev, Iqbal Grewal, Sherie Morrison, John M Timmerman
Journal: Blood (2011)
Non-Cytotoxic Differentiation Therapy Based On Mechanism of Disease Produces Complete Remission in Myelodysplastic Syndromes (MDS) with High Risk Cytogenetics
Authors: Reda Z Mahfouz, Englehaupt Rickki, Joyce A Juersivich, Kathleen Cooper, Lisa Durkin, Tomas Radivoyevitch, Ramon V. Tiu, Frederic J. Reu, Robert M Dean, Ronald Sobecks, Matt Kalaycio, Edward A. Copelan, Anjali Advani, Eric D. Hsi, Mikkael A Sekeres, Jaroslaw P. Maciejewski, Yogenthiran Saunthararajah
Journal: Blood (2012)
Autologous Stem Cell Transplantation (AutoSCT) in First Remission of Follicular Lymphoma (FL) "Save" Patients (pts) with Poor Prognosis. Results of the First Russian Prospective Study
Authors: Ekaterina Nesterova, Sergey Kravchenko, Elena Baryakh, Anna Misyurina, Yana Mangasarova, Vladimir Vorobyev, Tatyana Gaponova, Eduard Gemdzhian, Andrey Vorobyev, Valeri Savchenko
Journal: Blood (2015)
Multidrug Resistance Gene (MDR1) C3435T Polymorphism and Imatinib Response in Patients with Chronic Myeloid Leukemia
Authors: Ahmet Emre Eskazan, Suzin Catal Tatonyan, Ayse Salihoglu, Emine Gulturk, M. Cem Ar, Seniz Ongoren Aydin, Zafer Baslar, A. Burhan Ferhanoglu, Nukhet Tuzuner, Yildiz Aydin, Ugur Ozbek, Teoman Soysal
Journal: Blood (2011)
Targeting the Cyclin D - CDK4/6 - Rb Axis in Mantle Cell Lymphoma with the Novel Translation Inhibitor Silvestrol,
Authors: Lapo Alinari, Ryan B. Edwards, Courtney J. Prince, William H. Towns, Rajeswaran Mani, Amy Lehman, Xiaoli Zhang, David Jarjoura, Li Pan, A. Douglas Kinghorn, Michael R. Grever, Robert A. Baiocchi, David M. Lucas
Journal: Blood (2011)
Gene Expression Profiling of CD34+ Cells in Patients with Myelodysplastic Syndromes
Authors: Andrea Pellagatti, Mario Cazzola, Aristoteles Giagounidis, Janet Perry, Luca Malcovati, Matteo Della Porta, Martin Jädersten, Sally Killick, Eva Hellström-Lindberg, James S. Wainscoat, Jacqueline Boultwood
Journal: Blood (2008)
Research of Apoptosis Induction by the Application of Magnetic Nanoparticle of Fe3O4 Loaded with Daunorubicin and 5-Bromotetrandrine in K562/A02 Leukemic Cells
Authors: Bao-An Chen, Ming-fang Shen, Jian Cheng, Feng Gao, Wen-lin Xu, Hui-lin Shen, Jia-hua Ding, Chong Gao, Yun-Yu Sun, Jun Wang, Gang Zhao, Hui-hui Song, Wen Bao, Xin-chen Sun, Hong-yan Cheng, Yu-xia Deng, Guo-hong Li, Li-jie Liu, Wen-ji Chen, Jue-qiong Wang, Peng Yuan, Xiao-ping Pei, Ning-na Chen, Xue-mei Wang
Journal: Blood (2008)
Comparison Between Lymphoglobuline- and Thymoglobuline-Based Immunosuppressive Therapy as First-Line Treatment for Patients with Aplastic Anemia.
Authors: Carlos Vallejo, Pau Montesinos, Ana Rosell, Salut Brunet, Raul Córdoba, Elena Pérez-Ceballos, Josep Petit, Julián Sevilla, Enrique Colado, Alejandro Martín, Reyes Arranz, Javier de la Serna, Ildefonso Espigado, Ángel Cedillo
Journal: Blood (2009)
Hepcidin as a Therapeutic Tool to Limit Iron Overload and Improve Anemia In β-Thalassemia
Authors: Sara Gardenghi, Pedro Ramos, Cindy N. Roy, Nancy C. Andrews, Elizabeta Nemeth, Xiuli An, Mohandas Narla, Yelena Ginzburg, Eliezer A. Rachmilewitz, Patricia Giardina, Robert W Grady, Stefano Rivella
Journal: Blood (2010)
Next-Generation Bisulfite Sequencing of Aml Reveals Widespread Acquisition of Epigenetic Abnormalities in Leukemic Stem Cells That Are Stably Retained in More Mature Leukemic Cell Fractions
Authors: Lauren Suarez, Tingting Qin, Kristen Meldi, Manjusha Thakar, Sarah Sakoian, Jonathan M. Gerber, Gabriel Ghiaur, Hetty E. Carraway, Maria E Figueroa, Steven D. Gore
Journal: Blood (2015)
The Valproic Acid-Fludarabine Combination Induces a Synergistic Response in Chronic Lymphocytic Leukemia Via a Mechanism Involving the Lysosomal Protease Cathepsin B.
Authors: Ju-Yoon Yoon, David Szwajcer, Ganchimeg Ishdorj, Pat Benjaminson, James B Johnston, Spencer B Gibson
Journal: Blood (2012)
Bortezomib (Velcade™) and the Bcl-2 Inhibitor HA14-1 Synergistically Stimulate Apoptosis in EBV-Transformed Lymphocytes: A Potential Approach to Treatment of EBV-Associated Lymphoproliferative Disorders.
Authors: Pavani Srimatkandada, Regina Loomis, Jill Lacy
Journal: Blood (2005)
Management of concussion in disability sport: a different ball game?
Authors: Liam Richard West, Steffan Griffin, Richard Weiler, Osman Hassan Ahmed
Journal: British Journal of Sports Medicine (2016)

Concussion management in sport is a serious medical issue. Frequent high-profile incidents coupled with ongoing debate and research surrounding the definition, diagnosis and management of concussion mean that it is likely to remain a hot topic.1 Internationally, concussion has become a key focus for many sporting governing bodies, with a range of educational campaigns aimed at improving recognition and management.2

Football is the world's most popular global sport, and appropriately many disability football leagues have been developed to provide competitive opportunities for those individuals with disability wishing to compete outside ‘mainstream’ football. Adapted versions of football for athletes with major disabilities including learning disability; visual impairment; cerebral palsy/acquired brain injury; hearing impairment and amputation are all in existence. There has been a suggestion of an increased risk of musculoskeletal injury and head injury from participation, including concussion.3

However, at present the rates of and best-practice assessment and management for concussion …
Discovery and Validation of Agonistic Angiotensin Receptor Autoantibodies as Biomarkers of Adverse Outcomes
Authors: Peter M. Abadir, Alka Jain, Laura J. Powell, Qian-Li Xue, Jing Tian, Robert G. Hamilton, David A. Bennett, Thomas Finucane, Jeremy D. Walston, Neal S. Fedarko
Journal: Circulation (2016)

Background: Agonistic angiotensin II type 1 receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or risk for adverse health outcomes. AT1RaAbs could be used to stratify patient risk and to identify patients who can benefit from angiotensin receptor blocker treatment. Methods: Demographic and physiological covariates were measured in a discovery set of community-dwelling adults from Baltimore (N=255) and AT1RaAb associations with physical function tests and outcomes assessed. A group from Chicago (N=60) was used for validation of associations and to explore the impact of angiotensin receptor blocker treatment. Results: The Baltimore group had 28 subjects with falls, 32 frail subjects, and 5 deaths. Higher AT1RaAbs correlated significantly with interleukin-6 (Spearman r =0.33, P &lt;0.0001), systolic blood pressure (Spearman r =0.28, P &lt;0.0001), body mass index (Spearman r =0.28, P &lt;0.0001), weaker grip strength (Spearman r =–0.34, P &lt;0.01), and slower walking speed (Spearman r =–0.30, P &lt;0.05). Individuals with high AT1RaAbs were 3.9 (95% confidence interval, 1.38–11.0) times more likely to be at high risk after adjusting for age ( P &lt;0.05). Every 1 µg/mL increase in AT1RaAbs increased the odds of falling 30% after adjusting for age, sex, body mass index, and blood pressure. The Chicago group had 46 subjects with falls and 60 deaths. Serum AT1RaAb levels were significantly correlated with grip strength (Spearman r =–0.57, P &lt;0.005), walking speed (Spearman r =–0.47, P &lt;0.005), and falls (Spearman r =0.30, P &lt;0.05). Every 1 µg/mL increase in AT1RaAbs, decreased time to death by 9% after adjusting for age, sex, body mass index, and blood pressure. Chronic treatment with angiotensin receptor blockers was associated with better control of systolic blood pressure and attenuation of decline in both grip strength and time to death. Conclusions: In older individuals, higher AT1RaAb levels were associated with inflammation, hypertension, and adverse outcomes. Angiotensin receptor blocker treatment may blunt the harm associated with high levels of AT1RaAb.
Tissue Factor Firmly Immobilized on Surfaces Promotes Platelet Adhesion and Fibrin Formation in Studies with Circulating Human Blood: Importance of Shear Rate Conditions and FVIIa.
Authors: Raul Tonda, Irene Lopez-Vilchez, Ana M. Galan, Fulgencio Navalon, Marcos Pino, Rosa Hernandez, Antonio Ordinas, Gines Escolar
Journal: Blood (2006)
Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)
Authors: Hollie Hathaway, Jude Ajuebor, Liam Stephens, Aidan Coffey, Ursula Potter, J. Mark Sutton, A. Toby A. Jenkins
Journal: Journal of Controlled Release (2016)

Staphylococcus aureus infections of the skin and soft tissue pose a major concern to public health, largely owing to the steadily increasing prevalence of drug resistant isolates. As an alternative mode of treatment both bacteriophage endolysins and bacteriocins have been shown to possess antimicrobial efficacy against multiple species of bacteria including otherwise drug resistant strains. Despite this, the administration and exposure of such antimicrobials should be restricted until required in order to discourage the continued evolution of bacterial resistance, whilst maintaining the activity and stability of such proteinaceous structures. Utilising the increase in skin temperature during infection, the truncated bacteriophage endolysin CHAPK and the staphylococcal bacteriocin lysostaphin have been co-administered in a thermally triggered manner from Poly(N-isopropylacrylamide) (PNIPAM) nanoparticles. The thermoresponsive nature of the PNIPAM polymer has been employed in order to achieve the controlled expulsion of a synergistic enzybiotic cocktail consisting of CHAPK and lysostaphin. The point at which this occurs is modifiable, in this case corresponding to the threshold temperature associated with an infected wound. Consequently, bacterial lysis was observed at 37 °C, whilst growth was maintained at the uninfected skin temperature of 32 °C.
Frequent evolution of copy number alterations in CLL following first-line treatment with FC(R) is enriched with TP53 alterations: results from the CLL8 trial
Authors: J Edelmann, E Tausch, D A Landau, S Robrecht, J Bahlo, K Fischer, A M Fink, J Bloehdorn, K Holzmann, S Böttcher, L Werner, M Kneba, J G Gribben, D S Neuberg, C J Wu, M Hallek, H Döhner, S Stilgenbauer
Journal: Leukemia (2016)
Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China
Authors: Yuhai Bi, Quanjiao Chen, Qianli Wang, Jianjun Chen, Tao Jin, Gary Wong, Chuansong Quan, Jun Liu, Jun Wu, Renfu Yin, Lihua Zhao, Mingxin Li, Zhuang Ding, Rongrong Zou, Wen Xu, Hong Li, Huijun Wang, Kegong Tian, Guanghua Fu, Yu Huang, Alexander Shestopalov, Shoujun Li, Bing Xu, Hongjie Yu, Tingrong Luo, Lin Lu, Xun Xu, Yang Luo, Yingxia Liu, Weifeng Shi, Di Liu, George Fu Gao
Journal: Cell Host & Microbe (2016)
Targeting Functional Decline in Alzheimer Disease
Authors: Christopher M. Callahan, Malaz A. Boustani, Arlene A. Schmid, Michael A. LaMantia, Mary G. Austrom, Douglas K. Miller, Sujuan Gao, Denisha Y. Ferguson, Kathleen A. Lane, Hugh C. Hendrie
Journal: Annals of Internal Medicine (2016)

Background: Alzheimer disease results in progressive functional decline, leading to loss of independence. Objective: To determine whether collaborative care plus 2 years of home-based occupational therapy delays functional decline. Design: Randomized, controlled clinical trial. (ClinicalTrials.gov: NCT01314950) Setting: Urban public health system. Patients: 180 community-dwelling participants with Alzheimer disease and their informal caregivers. Intervention: All participants received collaborative care for dementia. Patients in the intervention group also received in-home occupational therapy delivered in 24 sessions over 2 years. Measurements: The primary outcome measure was the Alzheimer's Disease Cooperative Study Group Activities of Daily Living Scale (ADCS ADL); performance-based measures included the Short Physical Performance Battery (SPPB) and Short Portable Sarcopenia Measure (SPSM). Results: At baseline, clinical characteristics did not differ significantly between groups; the mean Mini-Mental State Examination score for both groups was 19 (SD, 7). The intervention group received a median of 18 home visits from the study occupational therapists. In both groups, ADCS ADL scores declined over 24 months. At the primary end point of 24 months, ADCS ADL scores did not differ between groups (mean difference, 2.34 [95% CI, −5.27 to 9.96]). We also could not definitively demonstrate between-group differences in mean SPPB or SPSM values. Limitation: The results of this trial are indeterminate and do not rule out potential clinically important effects of the intervention. Conclusion: The authors could not definitively demonstrate whether the addition of 2 years of in-home occupational therapy to a collaborative care management model slowed the rate of functional decline among persons with Alzheimer disease. This trial underscores the burden undertaken by caregivers as they provide care for family members with Alzheimer disease and the difficulty in slowing functional decline. Primary Funding Source: National Institute on Aging.
Correlation of Gene Mutation Status with Copy Number Profile in Uveal Melanoma
Authors: Serdar Yavuzyigitoglu, Wojtek Drabarek, Kyra N. Smit, Natasha van Poppelen, Anna E. Koopmans, Jolanda Vaarwater, Tom Brands, Bert Eussen, Hendrikus J. Dubbink, Job van Riet, Harmen J.G. van de Werken, Berna Beverloo, Robert M. Verdijk, Nicole Naus, Dion Paridaens, Emine Kilic, Annelies de Klein
Journal: Ophthalmology (2016)
Carfilzomib Exerts Anti-Neoplastic Activity in Waldenstrom Macroglobulinemia.
Authors: Antonio Sacco, Aldo M. Roccaro, Monette Aujay, Hai Ngo, Feda Azab, Abdel Kareem Azab, Molly R Melhem, Judith M. Runnels, Phong Quang, Susan Demo, Irene Ghobrial
Journal: Blood (2009)
Flow Cytometry Based Chimerism Analysis Can Predict Graft Rejection in Pediatric Patients Receiving HLA Mismatched Stem Cell Transplantation
Authors: Heiko-Manuel Teltschik, Hanna Kreil, Patrick Schlegel, Tobias F. Feuchtinger, Michael Schumm, Rupert Handgretinger, Peter Lang
Journal: Blood (2012)
Novel AKT Inhibitor GSK2110183 Shows Favorable Safety, Pharmacokinetics, and Clinical Activity in Multiple Myeloma. Preliminary Results From a Phase I First-Time-In-Human Study
Authors: Andrew Spencer, Sung-Soo Yoon, Simon J. Harrison, Shannon Morris, Deborah Smith, Steven J. Freedman, Richard Brigandi, Allen Oliff, Joanna B. Opalinska, Christine Chen
Journal: Blood (2011)
Rapid Diagnosis of Multidrug Resistance In Leukemia by Electrochemical Biosensor Based on Carbon Nanotubes–Drug Supramolecular Interaction
Authors: Bao-An Chen, Hai-jun Zhang, Xue-mei Wang, Hui Jiang, Chong Gao, Feng Gao, Jia-hua Ding, Jian Cheng, Hui-hui Song, Jun Wang, Wen Bao, Yun-yu Sun
Journal: Blood (2010)
Effect of team medical palliative care on chemotherapy for outpatients
Authors: Kouseki Hirade, Sayaka Adachi, Yoko Yasue, Makoto Takeuchi, Fumio Sakashita, Fumiko Suzuki, Yoko Kobayashi, Takako Imazaki, Takeshi Kato, Yutaka Ozeki
Journal: Annals of Oncology (2015)