tbuckley/cabot-search huggingface dataset:
Monetary Costs of Dementia in the United States
Authors: Michael D Hurd, Paco Martorell, Kenneth M Langa
Journal: New England Journal of Medicine (2013)

BACKGROUND-Dementia affects a large and growing number of older adults in the United States.The monetary costs attributable to dementia are likely to be similarly large and to continue to increase.METHODS-In a subsample (856 persons) of the population in the Health and Retirement Study (HRS), a nationally representative longitudinal study of older adults, the diagnosis of dementia was determined with the use of a detailed in-home cognitive assessment that was 3 to 4 hours in duration and a review by an expert panel.We then imputed cognitive status to the full HRS sample (10,903 persons, 31,936 person-years) on the basis of measures of cognitive and functional status available for all HRS respondents, thereby identifying persons in the larger sample with a high probability of dementia.The market costs associated with care for persons with dementia were determined on the basis of self-reported out-of-pocket spending and the utilization of nursing home care; Medicare claims data were used to identify costs paid by Medicare.Hours of informal (unpaid) care were valued either as the cost of equivalent formal (paid) care or as the estimated wages forgone by informal caregivers. RESULTS-The estimated prevalence of dementia among persons older than 70 years of age in the United States in 2010 was 14.7%.The yearly monetary cost per person that was attributable to dementia was either $56,290 (95% confidence interval [CI], $42,746 to $69,834) or $41,689 (95% CI, $31,017 to $52,362), depending on the method used to value informal care.These individual costs suggest that the total monetary cost of dementia in 2010 was between $157 billion and $215 billion.Medicare paid approximately $11 billion of this cost.CONCLUSIONS-Dementia represents a substantial financial burden on society, one that is similar to the financial burden of heart disease and cancer.(Funded by the National Institute on Aging.)Dementia, a chronic disease of aging characterized by progressive cognitive decline that interferes with independent functioning, 1 affects a large and growing number of older adults in the United States. 2,3Citing the growing effect of dementia on patients, families, and the
Effect of Iron and Cobalt Administration on the Iron-Containing Proteins of Rats Bearing the Walker Carcinosarcoma 256
Authors: Kampschmidt, Ralph F., Goodwin, Wilma L., Adams, Mabelle E.
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Effect of Iron and Cobalt Administration on the Iron-Containing Proteins of Rats Bearing the Walker Carcinosarcoma 256 Get access Ralph F. Kampschmidt, Ralph F. Kampschmidt Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilma L. Goodwin, Wilma L. Goodwin Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma Search for other works by this author on: Oxford Academic PubMed Google Scholar Mabelle E. Adams Mabelle E. Adams Biomedical Division, The Samuel Roberts Noble Foundation, Inc., Ardmore, Oklahoma Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 21, Issue 5, November 1958, Pages 879–884, https://doi.org/10.1093/jnci/21.5.879 Published: 01 November 1958 Article history Received: 19 May 1958 Published: 01 November 1958
Design strategies and applications of biomaterials and devices for Hernia repair
Authors: Surge Kalaba, Ethan Gerhard, Joshua S. Winder, Eric M. Pauli, Randy S. Haluck, Jian Yang
Journal: Bioactive Materials (2016)

Hernia repair is one of the most commonly performed surgical procedures worldwide, with a multi-billion dollar global market. Implant design remains a critical challenge for the successful repair and prevention of recurrent hernias, and despite significant progress, there is no ideal mesh for every surgery. This review summarizes the evolution of prostheses design toward successful hernia repair beginning with a description of the anatomy of the disease and the classifications of hernias. Next, the major milestones in implant design are discussed. Commonly encountered complications and strategies to minimize these adverse effects are described, followed by a thorough description of the implant characteristics necessary for successful repair. Finally, available implants are categorized and their advantages and limitations are elucidated, including non-absorbable and absorbable (synthetic and biologically derived) prostheses, composite prostheses, and coated prostheses. This review not only summarizes the state of the art in hernia repair, but also suggests future research directions toward improved hernia repair utilizing novel materials and fabrication methods.
Practicality of a lithium dosing guide
Authors: I F Naiman, C E Muniz, R B Stewart, R L Yost
Journal: American Journal of Psychiatry (1981)

A method of dosing lithium based on a 24-hour serum lithium level obtained after a single 600-mg oral dose of lithium carbonate has been reported to provide a steady-state lithium concentration of 0.6--1.2 mEq/liter. Since this regimen is widely used in clinical practice, the authors designed a study to determine the practicality of the dosing guide. Of 13 patients who followed this dosing protocol, 4 (30.7%) failed to achieve the defined steady-state range. The authors discuss factors that may affect the reliability of the dosing guide.
Africa
Authors: Mary E Black
Journal: BMJ (2007)

My auntie, Kate Fitzgerald, lives in Cork and I live in Belgrade. I have to juggle flights, family, and pressing work deadlines to reach her nursing home in a small village so as to have a clear two hours to spare for the visit.

Auntie Kate—the fearless Irish nun and missionary surgeon who ran district hospitals in Nigeria and Malawi. Deceptively small and pious, she had seemed the epitome of glamour and feistiness and had inspired my dream of working as a doctor in Africa—a dream I nurtured for years through medical school and junior doctor jobs in child health, obstetrics, and tropical medicine. A dream watched over by a little wooden elephant that I still keep on my dresser. Circumstances and choice had led me to another reality and another busy and interesting life.

I rush in the door to be stopped in my tracks; the matron tells me that Auntie Kate now usually sleeps until midday and has only just got up. Slowly, slowly they arrange her morning finery.

Our time clocks meet. Mine threatens to race past her until I put on the brakes; hers speeds up as she has a visitor. An aide wheels her to a sitting room, and another age passes while we organise her hearing aids. There she sits, 84, blind and almost completely deaf, frail as a waif.

She recognises my voice, and to see such a warm smile on a blind old lady's face is as good as watching your small child smile in its sleep. We hold hands and she feels my face a little and then we talk.

Phrases and stories bubble to the surface half formed. The children and mothers, the hospitals and the other sisters, the politicians on first name terms, the making-do on a tiny budget, heroic operations in a power failure, rains and drought, celebrations. The bubbles pop and evaporate and tail off in a whispered word. I am the only one of her visitors now who asks about Africa, and I ask her only once a year or so. But she still remembers it all.

The tea arrives, and I help her with her large blue plastic mug; the only sound in the room is of her slow sipping. My important schedules fall into irrelevance, just as all hers are long gone. Then the train and the flight from Dublin and my children waiting back home intervene.

I pause to look back through the glass door. I see her veined, delicate hands, quietly at rest now in her lap. I imagine them busy in surgical gloves, and the thousands upon thousands of sutures they have placed. I see the life she has led and I have not.

And as I gaze at those hands, once again I see Africa.
Unusual Neoplastic Lesions of the Uterine Horns of Estrogen-Treated Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Gardner, W. U., Ferrigno, M.
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Unusual Neoplastic Lesions of the Uterine Horns of Estrogen-Treated Mice Get access W. U. Gardner, W. U. Gardner Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Ferrigno M. Ferrigno Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages 601–613, https://doi.org/10.1093/jnci/17.5.601 Published: 01 November 1956 Article history Received: 29 May 1956 Published: 01 November 1956
ADENOMAS OF THE LIVER.
Authors: A M Kishko
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Borderline personality disorder in adolescents: ubiquitous or specific?
Authors: K E Garnet, K N Levy, J J Mattanah, W S Edell, T H McGlashan
Journal: American Journal of Psychiatry (1994)

The authors sought to identify diagnostic criteria that are relatively specific to borderline personality disorder in severely ill adolescent inpatients and that may predict a stable borderline personality disorder during this turbulent time. Twenty-one adolescent inpatients with borderline personality disorder were contacted 2 years after the index hospitalization (baseline). Seven of these patients met criteria for borderline personality disorder at follow-up. The ability of baseline criteria for borderline personality to predict the diagnosis of borderline personality disorder at follow-up was determined. Criteria for borderline personality disorder were sensitive for the stable disorder but not very specific. Without follow-up data, the diagnostic significance of symptoms of borderline personality disorder in adolescents appears uncertain.
Tuberculosis and Treatment with Infliximab
Authors: Sean Riminton, Nicholas Pearce, Basten Antony
Journal: New England Journal of Medicine (2002)

To the Editor: Sargent et al. (Oct.11 issue) 1 report that adjuvant chemotherapy with fluorouracil is as effective in older patients with resected colon cancer as it is in younger patients.Their conclusion is based on the absence of a statistically significant interaction between age and treatment effect for both overall and disease-free survival.However, the survival curves for treated and untreated patients who were more than 70 years old seem closer than the curves for treated and untreated younger patients.In our opinion, the absolute gain in survival is the measure that should be discussed with patients when deciding whether to use an adjuvant treatment.We suspect that the absolute differences in the study by Sargent et al. were small, and we would like to know what the absolute gain in survival was at each year of follow-up.
A Reconsideration of the Nature of the Neoplastic Reaction in the Light of Recent Advances in Cancer Research
Authors: Bryan, W. Ray
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article A Reconsideration of the Nature of the Neoplastic Reaction in the Light of Recent Advances in Cancer Research Get access W. Ray Bryan W. Ray Bryan Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 24, Issue 1, January 1960, Pages 221–251, https://doi.org/10.1093/jnci/24.1.221 Published: 01 January 1960 Article history Received: 29 July 1959 Published: 01 January 1960
PWE-393 Reconstruction of the pelvic floor after abdominoperineal excision
Authors: NN Alam, SK Narang, IR Daniels, NJ Smart
Journal: Gut (2015)

<h3>Introduction</h3> Extralevator abdominoperineal excision (ELAPE) involves the en bloc excision of the levator muscles and the rectum and the wider excision can increase morbidity and wound complications tthat will require some form of perineal reconstruction. The aim of this review is to provide an overview of the evidence for the use of biological mesh in the reconstruction of the pelvic floor after abdominoperineal excision. <h3>Method</h3> A systematic search of PubMed was conducted using the search terms <i>‘ELAPE’, ‘extralevator abdominoperineal excision of rectum’</i>or <i>‘extralevator abdominoperineal resection’</i>. The search yielded 17 studies for analysis after inclusion and exclusion criteria were applied. <h3>Results</h3> There were a total of 1055 patients across 17 studies. A biological mesh was used in perineal reconstruction in 463 patients with 206 patients using cross-linked porcine dermal collagen (PermacolTM), 44 using porcine intestinal submucosa (Surgisis©), 136 using human acellular dermal matrix (HADM) and 9 using a combination of PermacolTM and Surgisis©. Two studies did not specify the type of biological mesh used. There were 41 perineal hernias reported but rates were not consistently reported in all studies. The most common complications were perineal wound infection and perineal pain. However, there are no standardised measures for reporting perineal outcomes following ELAPE. There are very few studies comparing the use of biological mesh for perineal reconstruction for ELAPE. Two case series compared biological mesh with myocutaneous flaps and one series compared laparoscopic ELAPE with laparoscopic and open APER. Only one RCT was identified that compared patients undergoing ELAPE with perineal reconstruction using a biological mesh, with patients undergoing a conventional APER with no mesh. There was no significant difference in perineal hernia rates or perineal wound infections between the two groups although there were fewer positive circumferential resection margins in the ELAPE group. <h3>Conclusion</h3> The literature suggests that perineal closure using a biological mesh produces wound infection and complication rates that are comparable to other methods of reconstruction such as myocutaneous flaps. Biological mesh-assisted perineal reconstruction is a promising technique to improve wound healing but the results from high-quality prospective RCTs are required or national/international collaborative audits using statistical process control as a methodology of assessment of improvement. <h3>Disclosure of interest</h3> None Declared.
Giant Hemangioma with Thrombocytopenia
Authors: G J HILL, L A LONGINO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A modest proposal for consultation/liaison psychiatry in the 1980s
Authors: R E Hales, P J Fink
Journal: American Journal of Psychiatry (1982)

The authors discuss how consultation/liaison psychiatry has promoted closer cooperation between primary care and psychiatry in the general hospital setting and has increased physician concern for psychosocial issues while at the same time creating financial and organizational problems for consultation/liaison programs. To remedy these difficulties, the authors propose that all general hospitals that have more than 350 beds have fully staffed consultation/liaison services and that these services be funded through third-party reimbursement formulas as an integral hospital-based service. They outline six potential benefits of their proposal and suggest that action must be taken now if consultation/liaison psychiatry is not to suffer the same fate as the community mental health center movement.
Heterogeneous Epstein-Barr virus infection patterns in peripheral T- cell lymphoma of angioimmunoblastic lymphadenopathy type
Authors: I Anagnostopoulos, M Hummel, T Finn, M Tiemann, P Korbjuhn, C Dimmler, K Gatter, F Dallenbach, MR Parwaresch, H Stein
Journal: Blood (1992)
Fluoroscopically guided removal of a retained sheared guidewire following failed endoscopic ultrasound-guided pancreatic duct drainage
Authors: Hoonsub So, Do Park, Kyoungwon Jung, Sang Lee, Dong Seo, Sung Lee, Myung-Hwan Kim
Journal: Endoscopy (2015)

A 50-year-old man with a retained sheared guidewire in the main pancreatic duct and pancreatic parenchyma was referred for recurrent pancreatitis. He had previously undergone a pancreaticoduodenectomy for pancreatic hemangioma and was experiencing recurrent pancreatitis due to pancreaticojejunostomy stricture. Endoscopic ultrasound-guided pancreaticogastrostomy (EUS-PG) had been attempted at another hospital. However, this procedure had failed, and part of a 0.035-in guidewire (Roadrunner; Cook Medical, Bloomington, Indiana, USA) was retained in the pancreatic duct and pancreatic parenchyma ( [Fig. 1]).
Toward more rational management for stage I testis cancer: watch out for "watch and wait"!
Authors: M B Garnick, J P Richie
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.7.1021 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3723162 Toward more rational management for stage I testis cancer: watch out for "watch and wait"! M B GarnickxM B GarnickSearch for articles by this author , J P RichiexJ P RichieSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.7.1021 First Page PDF © 1986 by American Society of Clinical Oncology
SP0039 NM Wulffraat for the Share Consortium
Authors: N. Wulffraat
Journal: Annals of the Rheumatic Diseases (2015)

The SHARE project (funded by European Agency Health and Consumers under 2011 1202) deals with the specific needs for optimal care in Pediatric Rheumatic Diseases in each EU country. Optimal care includes diagnosis, management of disease and providing both drug- and non-drug therapies. Diseases of interest are JIA, SLE, juvenile dermatomyositis, scleroderma, vasculitis, APS and periodic fevers. The aim of the project is identify best practices based on a systematic literature review. At various consensus meetings statements are now selected for recommendations for best practices (organization of care, diagnosis and therapy). In order to reinforce the existing networks of PRES and PRINTO a survey on specific needs and practices was performed. Based on the replies or more than 127 pediatric rheumatology centers a detailed map of current practices and needs can be drawn. The Patient9s view is incorporated using a detailed webbased survey (in more than 12 languages) that is currently recruiting. Separate workpackages analyse ethical and legal regulations regarding participation of minor in research and educational programmes. The final conclusions will be presented at an international meeting later this this year for all involved stakeholders such as health care authorities, insurance companies, pharma, patients and health care providers. <h3>Disclosure of Interest</h3> None declared
SAT0336 Development of an Algorithm to Identify Serious Opioid Toxicity in Children
Authors: C.P. Chung, S.T. Callahan, W.O. Cooper, K.T. Murray, K. Hall, J.A. Dudley, C.M. Stein, W.A. Ray
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The use of opioids is increasing in children; therefore, opioid toxicity could be a public health problem in this vulnerable population. However, we are not aware of a published algorithm to identify cases of opioid toxicity in children using administrative databases. <h3>Objectives</h3> We sought to develop an algorithm to identify cases of opioid toxicity in children using administrative databases. <h3>Methods</h3> After review of literature and de-identified computer profiles, a broad set of ICD-9 CM codes consistent with serious opioid toxicity was selected. Based on these codes, we identified 195 potential cases of opioid toxicity in children enrolled in Tennessee Medicaid. Medical records were independently reviewed by two physicians; episodes considered equivocal were reviewed by an adjudication committee. Cases were adjudicated as definite/probable, possible, or were excluded. <h3>Results</h3> Of the 195 potential cases, 168 (86.2%) had complete records for review and 85 were confirmed cases. The overall positive predictive value (PPV) for all codes was 50.6%. The PPV for codes indicating: unintentional opioid overdose (25/31) was 80.7%; intentional opioid overdose (15/30) was 50.0%, adverse events (33/58) was 56.9%, the presence of signs or symptoms compatible with opioid toxicity (12/47) was 25.5%, and no cases were confirmed in records from the two deaths. Of the confirmed cases, 65.8% were related to therapeutic opioid use. <h3>Conclusions</h3> The collective and individual PPV for many ICD-9 CM codes consistent with opioid toxicity is low. For studies utilizing administrative claims, medical record review is to be important to accurately identify episodes of opioid toxicity and optimize case ascertainment. <h3>Disclosure of Interest</h3> None declared
ABVD versus MOPP: which is better?
Authors: S A Rosenberg
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.1.7 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2433410 ABVD versus MOPP: which is better? S A RosenbergxS A RosenbergSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.1.7 PDF "ABVD versus MOPP: which is better?." Journal of Clinical Oncology, 5(1), p. 7© 1987 by American Society of Clinical Oncology