tbuckley/cabot-search huggingface dataset:
PTH-038 Bowel Scope Screening Programme; Depth of Insertion and Comfort Scores are Related to Type of Endoscope Used: Abstract PTH-038 Table 1
Authors: R Warburton, R Tighe
Journal: Gut (2016)

<h3>Introduction</h3> The Norwich Bowel Cancer Screening Centre was one of the initial pilot sites for launch of the Bowel Scope screening programme (BCSP) commencing in May 2014. Two key performance indicators of the Bowel Scope programme is the adenoma detection rate (ADR) and patient comfort scores. It has been shown previously that the depth of insertion correlates positively with the ADR.<sup>1</sup> Speculation has been made that the use of paediatric and slim colonoscopes allow for deeper insertion, possibly due to better comfort scores. It has also been suggested that deeper insertion may lead to higher levels of reported discomfort. <h3>Methods</h3> We have analysed data on BCSS from the last 2 years derived from the Norwich Screening Centre. In total 8 different types of endoscopes were used; Olympus 240, 260, 240 imager, 260 High definition, paediatric, superslim, Pentax colonoscopes and gastroscopes. A total of 4462 procedures were performed. The procedures were stratified by type of scope used and examined for depth of insertion and comfort scores. <h3>Results</h3> Procedures terminated in the splenic flexure were associated with less discomfort when compared to those terminated in the descending colon and sigmoid (mild to moderate discomfort 5.3% splenic flexure, 13.1% descending colon, 37.6% sigmoid colon). This suggests that it is discomfort that prevents deep insertion rather than deep insertion causing discomfort. Procedures using paediatric or superslim colonoscopes have higher reported rates of no discomfort when compared to standard colonoscopes (76.8% vs 65.8%, x<sup>2 </sup>=5.98, p = 0.05). Pentax gastroscopes were also reported as having better comfort scores when compared to Pentax colonoscopes (68.8% vs 63%) although this was not statistically significant, mainly due to the small numbers of procedures using gastroscopes. Paediatric and super slim scopes are also associated with deeper insertion (42.4% to splenic flexure vs 32.8% in standard colonoscopes, x<sup>2 </sup>= 5.85, p = 0.05) <h3>Conclusion</h3> Paediatric, Pentax gastroscopes and superslim endoscopes are associated with better comfort scores and deeper insertion. Therefore they should be used routinely on the Bowel Scope Screening Programme. <h3>Reference</h3> 1 Warburton R, Meagher U, Tighe R. Bowel Scope Screening Programme: Depth of Insertion and Withdrawal Times vs Adenoma Detection Rate. <i>Gut</i>. 2015 June;<b>64</b>(Suppl 1):A411.1–A411 <h3>Disclosure of Interest</h3> None Declared
An Engineered Breast Cancer Model on a Chip to Replicate ECM‐Activation In Vitro during Tumor Progression
Authors: Filomena Gioiella, Francesco Urciuolo, Giorgia Imparato, Virginia Brancato, Paolo A. Netti
Journal: Advanced Healthcare Materials (2016)

In this work, a new model of breast cancer is proposed featuring both epithelial and stromal tissues arranged on a microfluidic chip. The main task of the work is the in vitro replication of the stromal activation during tumor epithelial invasion. The activation of tumor stroma and its morphological/compositional changes play a key role in tumor progression. Despite emerging evidences, to date the activation of tumor stroma in vitro has not been achieved yet. The tumor-on-chip proposed in this work is built in order to replicate the features of its native counterpart: multicellularity (tumor epithelial cell and stromal cell); 3D engineered stroma compartment composed of cell-assembled extracellular matrix (ECM); reliable 3D tumor architecture. During tumor epithelial invasion the stroma displayed an activation process at both cellular and ECM level. Similarly of what repeated in vivo, ECM remodeling is found in terms of hyaluronic acid and fibronectin overexpression in the stroma compartment. Furthermore, the cell-assembled ECM featuring the stromal tissue, allowed on-line monitoring of collagen remodeling during stroma activation process via real time multiphoton microscopy. Also, trafficking of macromolecules within the stromal compartment has been monitored in real time.
A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation
Authors: Jun Zhao, Yi Zeng, Simin Xu, Jie Chen, Guobo Shen, Caiqun Yu, David Knipe, Weiming Yuan, Jian Peng, Wenqing Xu, Chao Zhang, Zanxian Xia, Pinghui Feng
Journal: Cell Host & Microbe (2016)
Immunotherapy with Recombinant Xenogeneic Vascular Endothelial Growth Factor as a Vaccine Combined Low-Dose Adriamycin Induces Synergistic Antitumor Efficacy in EL4 Lymphoma Model.
Authors: Ting Niu, Ting Liu, Yong-qian Jia, Yan-jun Wen, Ling Tian, Ji-yan Liu, Yang Wu, Bing Hu, Yu-quan Wei
Journal: Blood (2005)
Is It Possible to Stop Imatinib in Patients with Chronic Myeloid Leukemia? An Update from a French Pilot Study and First Results from the Multicentre « Stop Imatinib » (STIM) Study
Authors: Francois-Xavier Mahon, Francoise Huguet, Francois Guilhot, Laurence Legros, Franck E Nicolini, Aude Charbonnier, Agnes Guerci, Delphine Rea, Bruno R. Varet, Martine Gardembas, Joelle Guilhot, Gabriel Etienne, Noel-Jean Milpied, Emilie Aton, Josy Reiffers, Philippe Rousselot
Journal: Blood (2008)
Long-term survival and late events after allogeneic stem cell transplantation from HLA-matched siblings for acute myeloid leukemia with myeloablative compared to reduced-intensity conditioning: a report on behalf of the acute leukemia working party of European group for blood and marrow transplantation
Authors: Avichai Shimoni, Myriam Labopin, Bipin Savani, Liisa Volin, Gerhard Ehninger, Jurgen Kuball, Donald Bunjes, Nicolaas Schaap, Stephane Vigouroux, Andrea Bacigalupo, Hendrik Veelken, Jorge Sierra, Matthias Eder, Dietger Niederwieser, Mohamad Mohty, Arnon Nagler
Journal: Journal of Hematology & Oncology (2016)

Myeloablative (MAC) and reduced-intensity conditioning (RIC) are established approaches for allogeneic stem cell transplantation (SCT) in acute myeloid leukemia (AML). Most deaths after MAC occur within the first 2 years after SCT, while patients surviving leukemia-free for 2 years can expect a favorable long-term outcome. However, there is paucity of data on the long-term outcome (beyond 10 years) and the pattern of late events following RIC due to the relative recent introduction of this approach.We analyzed long-term outcomes in a cohort of 1423 AML patients, age ≥50 years, after SCT from HLA-matched siblings, during the years 1997-2005, median follow-up 8.3 years (0.1-17).The 10-year leukemia-free survival (LFS) was 31 % (95CI, 27-35) and 32 % (28-35) after MAC and RIC, respectively (P = 0.57). The 10-year GVHD/ relapse-free survival (GRFS), a surrogate for quality of life was 22 % (18-25) and 21 % (18-24), respectively (P = 0.79). The 10-year non-relapse mortality (NRM) was higher and relapse rate was lower after MAC, throughout the early and late post-transplant course. The 10-year LFS among 584 patients surviving leukemia-free 2 years after SCT was 71 % (65-76) and 73 % (67-78) after MAC and RIC, respectively (P = 0.76). Advanced leukemia at SCT was the major predictor of LFS subsequent to the 2-year landmark. Relapse was the major cause of late death after both regimens; however, NRM and in particular chronic graft-versus-host disease and second cancers were more common causes of late death after MAC.Long-term LFS and GRFS are similar after RIC and MAC. Most events after RIC or MAC occur within the first 2 years after SCT. Patients who are leukemia-free 2 years after SCT can expect similar good subsequent outcome after both approaches.
Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system
Authors: Michael J. Workman, Maxime M. Mahe, Stephen Trisno, Holly M. Poling, Carey L. Watson, Nambirajan Sundaram, Ching Fang Chang, Jacqueline Schiesser, Philippe Aubert, Edouard G. Stanley, Andrew G. Elefanty, Yuichiro Miyaoka, Mohammad A. Mandegar, Bruce R Conklin, Michel Neunlist, Samantha A. Brugmann, Michael A. Helmrath, James M. Wells
Journal: Nature Medicine (2016)
A Mouse Model for XLP-2 Disease Uncovers a Critical Function for IL-1beta and TNF in Driving Hyper-Inflammation
Authors: Philipp J. Jost, Monica Yabal, Heiko Adler, Nathalie Knies, Christina Groß, Rune Busk Damgaard, Hirokazu Kanegane, Christian Peschel, Andreas Strasser, Olaf Groß, Jürgen Ruland, Mads Gyrd-Hansen
Journal: Blood (2014)
SAT0646-HPR Women with Psoriatic Arthritis Who Are Homemakers or Office Workers Declare Similar Difficulties during Working: Table 1
Authors: E. Kilic, G. Kilic, K. Nas, R. Cevik, E. Capkin, A.Z. Dagli, M. Karkucak, S. Ozgocmen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Psoriatic arthritis (PsA) is a chronic inflammatory arthritis associated with psoriasis. The differences between homemaker (HM) and working at paid work (PW) in women were not assessed. <h3>Objectives</h3> The aim of this study was to assess differences between being HM and working in PW in female patients with PsA related to clinical findings, quality of life and difficulties at working. <h3>Methods</h3> Female patients with PsA over the age of 18-year-old who met the CASPAR classification criteria were underwent clinical and laboratory evaluation by using standardized protocol and case report form, from three different universities outpatient9s clinics. Female patients with PsA were divided into age matched two group as a HM or working in PW. Patients who were HM or PW were asked to mark their level of difficulty during household works or office works respectively, on a 0–10 Likert scale. 0, indicated no difficulty during household/office works; 10, unable to do household/office works because of PsA and high scores indicated more difficulty. <h3>Results</h3> A total of 115 female patients with PsA (mean age 41.9±11.9 year) were included. Mean symptom duration was 10.7±9.3 year. Out of 86 (74.8%) patients with PsA were HM and 29 (25.2%) were working at a regular PW. Homemaker had higher body mass index than PW (25.1±7.4 vs 29.7±6.6 p=0.012). Dactylitis (current or having history) were higher in PW (58.6 vs 31.4% p=0.014) whereas enthesitis (current or having history) were higher in HM (27.6 vs 52.3% p=0.021). Disease activity measures (acute phase reactants, BASDAI, DAS28, VAS-pain, physician9s and patient9s global assessment, tender and swollen joint count), functional status and health related quality of life assessments (BASFI, BASMI, Duruoz hand index, SF-36, Nottingham health profile, psoriatic arthritis quality of life, hospital anxiety and depression scale, fatigue severity scale) were similar between HM and PW patients with PsA (p&gt;0.05). Level of difficulties in working at household works were 5.2±2.6 in HM and level of difficulties in office works were 5.3±2.3 (p=0.804) in PW. Depression risk (HAD-depression ≥7) was relatively higher in PW (59.3 vs 43.7%), but anxiety risk (HAD-anxiety ≥10) was relatively higher in HW (26.8 vs 22.2%) (p&gt;0.05). Fatigue severity scale score≥36 was associated with depression risk in all women with PsA by using univariate logistic regression analysis (OR: 5.1, 95% CI: 2.0–12.8 p&lt;0.0001). <h3>Conclusions</h3> Women with PsA who were homemakers or working in paid work do not differ from each other in terms of disease burden, health related quality of life, difficulties at homework or at office work.Furthermore, increased fatigue may be associated with depression risk in female patients with PsA. <h3>Disclosure of Interest</h3> None declared
Abstract 11809: Sodium Intake is Correlated to Total Calorie Intake and Potassium
Authors: Yoon Juneyoung, Kyoung-Woo Seo, Jin-Sun Park, Hyoung-Mo Yang, Hong-Seok Lim, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Eun-Hyun Lee, Juyong Lee, Gyo-Seung Hwang, Joon-Han Shin, Seoung-Jea Tahk
Journal: Circulation (2015)

Background: Selecting lower-sodium diets are not successful to reduce sodium intake in general population. If systemic approach is considered lowering sodium intake because of the culinary tendencies, we need to aware of the quantitative relationship between nutrients and sodium in daily usual food of the general population. Hypothesis: We assessed the hypotheses that are the positive correlation between total calorie intake, potassium and sodium intake; the cutoff values for sodium recommendation (≤2300 mg per day). Method: We studied 55,544 individuals who completed health examination and nutrition survey in 168,157 randomly selected participants that could represent the country from the 1998-2013 Korea National Health and Nutrition Examination Survey (KNHANES). The nutrition survey was 24 hours recall method to estimate the amount of standardized Korean food. We analyzed the quantitative relationship, and estimated the cutoff value of the total calories and potassium at the recommendation of the sodium intake. Result: The mean values were total calorie 1922±834 Kcal, sodium 4904±3218 mg, potassium 2935±1563 mg, protein 70±41 g (15% in total calorie), fat 37±31 (18%), and carbohydrate 312±123 (67%) in mean value. The standardized coefficients were potassium 0.309, protein 0.226, fat 0.070, carbohydrate 0.097 in model 1 (R2=0.402); total calorie 0.271 and potassium 0.368 in model 2 (R2=0.384) with cardiovascular risk factors in multiple linear regression analysis (table). The optical cutoff value of the total calorie for sodium 2300mg is 1520 Kcal (74% sensitivity, 74% specificity, 93% positive predictive value, 38% negative predictive value, area under the curve: 0.826, 95% CI: 0.82 to 0.83 ; p &lt; 0.001) and the potassium is 1956 mg (82% sensitivity, 69% specificity, 92% PPV, 44% NPV, AUC: 0.825, 95% CI: 0.82 to 0.83 ; p &lt;0.001). Conclusion: In conclusion, the cutoff values for the sodium 2300 mg are the total calorie 1520 Kcal and potassium 1956 mg.
Expand: a Phase 1b, Open-Label, Dose-Finding Study of Ruxolitinib in Patients with Myelofibrosis and Baseline Platelet Counts Between 50 × 109/L and 99 × 109/L
Authors: Claire N Harrison, Heinz Gisslinger, Carole B. Miller, Jean-Jacques Kiladjian, Edric Atienza, Viktoriya Stalbovskaya, Andres Sirulnik, Haifa Kathrin Al-Ali, Giovanni Barosi, Mary Frances McMullin, Srdan Verstovsek, Alessandro M. Vannucchi
Journal: Blood (2012)
T Cell Responses during Long-Term Continuous Infusion of MT103 (MEDI-538; Anti-CD19 BiTE) in Patients with Relapsed B-NHL: Data from Dose-Escalation Study MT103-104.
Authors: Matthias Klinger, Peter Kufer, Petra Kirchinger, Ralf Lutterbüse, Eugen Leo, Carsten Reinhardt, Patrick Bäuerle, Ralf Bargou
Journal: Blood (2006)
T Cells Engineered For Resistance To Mycophenolate Mofetil Demonstrate Enhanced Expansion and Improved Tumour Control In Immunosuppressed Hosts
Authors: James Edward Griffin, Shoa-An Xue, Benjamin J Carpenter, Pedro Velica, Angelika Holler, Sara Ghorashian, Emma Nicholson, Martin Pule, Ronjon Chakraverty
Journal: Blood (2013)
High-Resolution Genomic Profiling (array-CGH) of Childhood T-ALL Identifies Deletions at 6q15-16.1 as a Predictive Marker for Early Treatment Response.
Authors: Marc Remke, Stefan Pfister, Martin Stanulla, Martin Schrappe, Martina Ulrike Muckenthaler, Peter Lichter, Andreas Kulozik
Journal: Blood (2008)
Efficacy and Safety of High-Intermediate-Purity VWF/FVIII Concentrates Given Repeatedly to Severe Patients with Von Willebrand Disease: An Italian Cohort Study on 32 Intensively Treated Cases.
Authors: Augusto B. Federici, Belinda J. Cedron, Barbara Scimeca, Maria T. Canciani, Pier M. Mannucci
Journal: Blood (2006)
A Phase III, Randomized, Open-Label Study of 400 Mg Versus 800 Mg of Imatinib Mesylate (IM) in Patients (pts) with Newly Diagnosed, Previously Untreated Chronic Myeloid Leukemia in Chronic Phase (CML-CP) Using Molecular Endpoints: 1-Year Results of TOPS (Tyrosine Kinase Inhibitor Optimization and Selectivity) Study
Authors: Jorge Cortes, Michele Baccarani, François Guilhot, Brian J. Druker, Susan Branford, Dong-Wook Kim, Fabrizio Pane, Marc Rudoltz, Richard Yu, LaTonya Collins, Tillmann Krahnke, Jerald P. Radich, Timothy P Hughes
Journal: Blood (2008)
FRI0020 BMP-2 and TGF-B Inhibit IL-34 Expression in Rheumatoid Arthritis Synovial Fibroblasts
Authors: M. Chemel-Mary, B. Legoff, Y. Maugars, D. Heymann, F. Verrechia
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Interleukin-34 (IL-34) is a pro-osteoclastogenic cytokine, up-regulated by pro inflammatory cytokines, with a recently described role in rheumatoid arthritis (RA). TGF-b and BMP-2 are two members of the TGF-b family, whith an opposit role to the pro-inflammatory cytokines and that are also involved in rheumatoid synovitis. <h3>Objectives</h3> The present study aimed to assess the IL-34 expression in response to two members of the TGF-b family, TGF-b1 and BMP-2, in synovial fibroblasts from RA patients. <h3>Methods</h3> The IL-34, TGF-β1 and BMP-2 productions were measured in synovial fluids by ELISA. The IL-34 mRNA levels were quantified by qPCR in human synovial fibroblasts and murine mesenchymal stem cells (MSCs). Pharmacological inhibitions were used to determine the involvement of ALK1 and ALK5 downstream TGF-b1 and BMP-2. <h3>Results</h3> IL-34, TGF-b1 and BMP-2 were expressed in synovial fluids from RA patients. We found a significant correlation between IL-34 and TGF-b1 expressions. Levels of both IL-34 and TGF-b1 were thus correlated with the total leukocyte counts in the synovial fluids. TGF-b1 and BMP-2 decreased Il-34 expression in the synovial fibroblasts or in mMSC in a dose/time dependent manner through respectively ALK5 and ALK1 pathways. In addition, TGF-b1 antagonized TNFa-induced IL-34 gene expression. <h3>Conclusions</h3> This work identifies TGF-b1 and BMP-2 as potent inhibitors of IL-34 expression in RA synovial fibroblasts. These cytokines, as upstream inhibitors of IL-34, may thus contribute to antagonize inflammation and bone erosions in RA. <h3>References</h3> Klareskog L, Catrina AI, Paget S. Rheumatoid arthritis. Lancet. 2009;373:659–72. Lin H, Lee E, Hestir K, Leo C, et al. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science. 2008;320:807–11. Baud9huin M, Renault R, Charrier C, et al. Interleukin-34 is expressed by giant cell tumours of bone and plays a key role in RANKL-induced osteoclastogenesis. J Pathol. 2010;221:77–86. Chemel M, Le Goff B, Brion R, et al. Interleukin 34 expression is associated with synovitis severity in rheumatoid arthritis patients. Ann Rheum Dis. 2012;71:150–4. Pohlers D, Beyer A, Koczan D, et al. Constitutive upregulation of the transforming growth factor-beta pathway in rheumatoid arthritis synovial fibroblasts. Arthritis Res Ther. 2007;9:R59. <h3>Disclosure of Interest</h3> None declared
Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study
Authors: Melissa J McDonnell, Stefano Aliberti, Pieter C Goeminne, Marcos I Restrepo, Simon Finch, Alberto Pesci, Lieven J Dupont, Thomas C Fardon, Robert Wilson, Michael R Loebinger, Dusan Skrbic, Dusanka Obradovic, Anthony De Soyza, Chris Ward, John G Laffey, Robert M Rutherford, James D Chalmers
Journal: The Lancet Respiratory Medicine (2016)
Small Steps Toward Asthma-Friendly School Environments
Authors: Elizabeth C. Matsui, Meredith C. McCormack
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Updated Results of a Phase I/II, Randomized Study of Clofarabine Combined with Idarubicin and Cytarabine (CIA) or Fludarabine Combined with Idarubicin and Cytarabine (FIA) for the Treatment of Patients (pts) with Newly Diagnosed or Relapsed/Refractory (RR) Acute Myeloid Leukemia (AML)
Authors: Michael S Mathisen, Hagop M. Kantarjian, Farhad Ravandi, Naveen Pemmaraju, Guillermo Garcia-Manero, Jorge E. Cortes, Susan O'Brien, Alfonso Quintas-Cardama, Hady Ghanem, Naval G. Daver, Sherry A. Pierce, Cynthia Lira, Stefan Faderl, Elias Jabbour
Journal: Blood (2012)
Computed Tomography and Cardiac Magnetic Resonance in Ischemic Heart Disease
Authors: Marc R. Dweck, Michelle C. Williams, Alastair J. Moss, David E. Newby, Zahi A. Fayad
Journal: Journal of the American College of Cardiology (2016)

Ischemic heart disease is a complex disease process caused by the development of coronary atherosclerosis, with downstream effects on the left ventricular myocardium. It is characterized by a long preclinical phase, abrupt development of myocardial infarction, and more chronic disease states such as stable angina and ischemic cardiomyopathy. Recent advances in computed tomography (CT) and cardiac magnetic resonance (CMR) now allow detailed imaging of each of these different phases of the disease, potentially allowing ischemic heart disease to be tracked during a patient's lifetime. In particular, CT has emerged as the noninvasive modality of choice for imaging the coronary arteries, whereas CMR offers detailed assessments of myocardial perfusion, viability, and function. The clinical utility of these techniques is increasingly being supported by robust randomized controlled trial data, although the widespread adoption of cardiac CT and CMR will require further evidence of clinical efficacy and cost effectiveness.