tbuckley/cabot-search huggingface dataset:
HG-54THE ROLE OF HIGH-DOSE MYELOABLATIVE CHEMOTHERAPY (HDCT) WITH HAEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) IN CHILDREN WITH HIGH GRADE GLIOMAS (HGG) OR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): RESULTS OF A SYSTEMATIC REVIEW
Authors: Caroline Main, Madeline Adams, Katherine Cooper, Sophie Wilne, Bob Phillips, Martin English, Pamela R. Kearns, Barry Pizer, Simon P. Stevens, Keith Wheatley, Jayne S. Wilson
Journal: Neuro-Oncology (2016)

HG-54. THE ROLE OF HIGH-DOSE MYELOABLATIVE CHEMOTHERAPY (HDCT) WITH HAEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) IN CHILDREN WITH HIGH GRADE GLIOMAS (HGG) OR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): RESULTS OF A SYSTEMATIC REVIEW Caroline Main1, Madeline Adams2, Katherine Cooper3, Sophie Wilne4, Bob Phillips5, Martin English6, Pamela R. Kearns1,6, Barry Pizer3, Simon P. Stevens1, Keith Wheatley1, and Jayne S. Wilson1; Cancer Research UK Clinical Trials Unit; University of Birmingham, Birmingham, UK; Bristol Children’s Hospital, Bristol, UK; Alder Hey Children’s NHS Foundation Trust, Liverpool, UK; Nottingham University Hospitals’ NHS Trust, Nottingham, UK; UK Centre for Reviews and Dissemination, University of York, UK; Birmingham Children’s Hospital NHS Foundation Trust, Birmingham, UK OBJECTIVES: To assess the impact of HDCT/HSCT in children with HGG or DIPG. METHODS: Ten electronic databases were searched from 1985 to Oct 2015 for studies assessing HDCT/HSCT in HGG and DIPG. Outcomes included overall survival (OS), response rates (RR), adverse events and treatment related mortality (TRM). Standard systematic review methods were used to minimise bias. RESULTS: For HGG, 167 patients were included, 56% newly diagnosed and 44% relapsed. Mean age was 8.7 years. Mean follow-up was 2.8-years (range: 0.2-5.4). HDCT mainly consisted of one cycle, with preor post radiotherapy (RT) used in 59% of patients. Median OS for newly diagnosed HGG was between 9-14 months (range: 1-65) (n 1⁄4 27), with one and four year OS 73%+13% (n 1⁄4 11) and 43% (n 1⁄4 21) respectively. Overall RR was 30% (n 1⁄4 26). For relapsed HGG median OS was 12.7months (n 1⁄4 18). Across the studies nine TRM occurred. Sixty-two patients with DIPG were included, 68% newly diagnosed and 32% relapsed. Mean age was 6.8-years. Median follow-up was 1.5 years (range: 0.1-7). HDCT consisted of one cycle, with 77% patients receiving prior RT. For newly diagnosed patients with DIPG, median OS was 10-11.4 months (range: 6.4-17.1) (n 1⁄4 42), and for relapsed patients 4.8 months (0.1-18.7) (n 1⁄4 16). Across the studies five toxicity related deaths occurred (8%). CONCLUSIONS: The limited evidence on HDCT/HSCT in children with HGG or DIPG does not allow reliable conclusions to be drawn. However, use of HDCT/HSCT in these patient groups is associated with a significant toxicity profile and TRM. Neuro-Oncology 18:iii48–iii77, 2016. doi:10.1093/neuonc/now073.50 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Tackling tuberculosis: progress made and challenges remaining for the European Union
Authors: Z Jakab
Journal: Eurosurveillance (2008)

World Tuberculosis Day on 24 March commemorates the date in 1882 when Robert Koch presented his findings on the causing agent of tuberculosis (TB) - Mycobacterium tuberculosis. This celebration provides a good opportunity to take stock of the achievements in controlling the disease so far - and the remaining challenges at global, regional, national and local level.
Update to an open-label clinical trial of vismodegib as neoadjuvant before surgery for high-risk basal cell carcinoma (BCC)
Authors: Gina P. Kwon, Mina Sarah Ally, Irene Bailey-Healy, Anthony E. Oro, Jinah Kim, Anne Lynn Chang, Sumaira Aasi, Jean Y. Tang
Journal: Journal of the American Academy of Dermatology (2016)
NS-27INFANTS WITH CENTRAL NERVOUS SYSTEM TUMOURS - A FIVE-YEAR RETROSPECTIVE REVIEW
Authors: Soumya Mukherjee, Ramakrishna Bethanabatla, Gnanamurthy Sivakumar, Atul Tyagi, Paul Chumas, John Goodden
Journal: Neuro-Oncology (2016)

NS-27. INFANTS WITH CENTRAL NERVOUS SYSTEM TUMOURS A FIVE-YEAR RETROSPECTIVE REVIEW Soumya Mukherjee, Ramakrishna Bethanabatla, Gnanamurthy Sivakumar, Atul Tyagi, PaulChumas, and John Goodden; Leeds General Infirmary,Leeds, UK INTRODUCTION: Central nervous system(CNS) tumours in children , 2 years are rare. We have studied tumour types, treatment and outcomes in children , 2 years treated at a single institution. METHOD: Retrospective analysis was undertaken of consecutive children under 2 years old with CNS tumours treated at a single institution between January 2011 to December 2015. Data collected included demographics, tumour location, histology, treatment details, and outcome. RESULTS: 32 patients were treated with a mean age of 10.8 months (range, 3.1 to 24 months) and male-to-female ratio of 1:1. 14 (44%) had posterior fossa tumours (PFT) and 18 (56%) supratentorial tumours (STT) with a rate of hydrocephalus of 93% (13/14) and 44% (8/18), respectively (p , 0.05). The rate of hydrocephalus across the cohort was 65%. Commonest histologies amongst the PFT group were ependymoma, pilocytic astrocytoma, and medulloblastoma, whilst amongst the STT group were ependymoma, pilomyxoid astrocytoma, primitive neuroectodermal tumour and choroid plexus papilloma. Other pathological types included atypical teratoid rhabdoid tumour (ATRT) and ependymoblastoma. Operative approaches included supratentorial (38%: total 25%, subtotal 13%); midline posterior fossa (25%: total 16%, subtotal 9%), retrosigmoid (16%), endoscopic biopsy +/resection (16%) and open biopsy (12.5%). CSF diversion surgery (VP shunt, EVD, ETV) was performed in 35% of patients. Overall complication rate was 9%. Median survival was 40 months and all-cause 5-year mortality was 23% (8/35). CONCLUSION: Our series demonstrates varied tumour diagnoses in infants , 2 years and their surgical challenges. Despite these good outcomes can be achieved. Neuro-Oncology 18:iii127–iii134, 2016. doi:10.1093/neuonc/now078.27 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
The Role of Hair Follicles in Methylcholanthrene Carcinogenesis in Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Hsu-mu Liang, E. V. Cowdry
Journal: JNCI Journal of the National Cancer Institute (1955)

The Role of Hair Follicles in Methylcholanthrene Carcinogenesis in Mice Get access Hsu-mu Liang, Hsu-mu Liang The Wernse Cancer Research Laboratory and the Department of Anatomy, Washington University, St. Louis, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. V. Cowdry E. V. Cowdry The Wernse Cancer Research Laboratory and the Department of Anatomy, Washington University, St. Louis, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 1, August 1955, Pages 205–223, https://doi.org/10.1093/jnci/16.1.205 Published: 01 August 1955 Article history Received: 26 April 1954 Published: 01 August 1955
Application of Radioreceptor Assay to Circulating Insulin, Growth Hormone, and to Their Tissue Receptors in Animals and Man
Authors: P. Gorden, J.R. Gavin, C.R. Kahn, J.A. Archer, M. Lesniak, C. Hendricks, D.M. Neville, J. Roth
Journal: Pharmacological Reviews (1973)
Intradermal Vaccination against Influenza
Authors: Thomas H Weller
Journal: New England Journal of Medicine (2005)

1. Belshe RB, Newman FK, Cannon J, et al. Serum antibody responses after intradermal vaccination against influenza. N Engl J Med 2004;351:2286-94. 2. Kenney RT, Frech SA, Muenz LR, Villar CP, Glenn GM. Dose sparing with intradermal injection of influenza vaccine. N Engl J Med 2004;351:2295-301. 3. Weller TH, Cheever FS, Enders JF. Immunologic reactions following the intradermal inoculation of influenza A and B vaccine. Proc Soc Exp Biol Med 1948;67:96-101.
LG-52THEOPHYLLINE IN VISION IMPAIRED CHILDREN WITH OPTIC PATHWAY GLIOMA
Authors: Gail Halliday, Peter Ling, Michal Zapotocky, Arun Reginald, Uri Tabori, Iris Fried, Eric Bouffet, Lee Dupuis, Ute Bartels
Journal: Neuro-Oncology (2016)

LG-52. THEOPHYLLINE IN VISION IMPAIRED CHILDREN WITH OPTIC PATHWAY GLIOMA Gail Halliday, Peter Ling, Michal Zapotocky, Arun Reginald, Uri Tabori, Iris Fried, Eric Bouffet, Lee Dupuis, and Ute Bartels; The Hospital for Sick Children, Toronto, ON, Canada PURPOSE: Preclinical models suggest that phosphodiesterase inhibitors may slow or prevent axonal damage to the optic nerve in mice with visual pathway glioma likely through elevation of cAMP. A feasibility study was performed to evaluate the safety and efficacy of theophylline in vision impaired children with optic pathway glioma (OPG) at risk of visual loss. METHODS: Patients were treated with theophylline for a planned duration of 12 months. Eight of the eleven patients received concurrent standard OPG chemotherapies. The initial theophylline dose was calculated based on ideal body mass and subsequently adjusted according to trough serum levels. The primary end point was safety, defined by grade 3-4 toxicity using the National Cancer Institute Common Toxicity Criteria version 4.0. Secondary end points included visual acuity response rate. RESULTS: Preliminary data analysis of eleven patients, with a median age of 9.2 years, treated with theophylline at the Hospital for Sick Children, Toronto between 2009 and 2015 is detailed here. After a mean duration of 10.5 months no grade 3-4 treatment related toxicities were identified. Of the three patients who discontinued therapy prematurely two experienced grade 1 toxicities. Three of eleven patients studied showed improvements in binocular vision whilst on theophylline therapy with a further three patients showing stabilization of vision. CONCLUSIONS: Combining theophylline with standard chemotherapies for OPG in children is safe and feasible. In a proportion of patients with progressive visual decline despite prior chemotherapy theophylline enabled stabilization or improvement in visual acuity. Phase III proof of efficacy trials are warranted. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.52 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Recent Changes in Relative Frequency of Various Histologic Types of Bronchogenic Carcinoma
Authors: Spain, David M.
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Recent Changes in Relative Frequency of Various Histologic Types of Bronchogenic Carcinoma Get access David M. Spain, M.D. David M. Spain, M.D. Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 23, Issue 3, September 1959, Pages 427–434, https://doi.org/10.1093/jnci/23.3.427 Published: 01 September 1959 Article history Received: 16 February 1959 Published: 01 September 1959
Vital Signs: Multistate Foodborne Outbreaks — United States, 2010–2014
Authors: Samuel J. Crowe, Barbara E. Mahon, Antonio R. Vieira, L. Hannah Gould
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Millions of U.S. residents become ill from foodborne pathogens each year. Most foodborne outbreaks occur among small groups of persons in a localized area. However, because many foods are distributed widely and rapidly, and because detection methods have improved, outbreaks that occur in multiple states and that even span the entire country are being recognized with increasing frequency.This report analyzes data from CDC's Foodborne Disease Outbreak Surveillance System to describe multistate foodborne outbreaks that occurred in the United States during 2010-2014.During this 5-year period, 120 multistate foodborne disease outbreaks (with identified pathogen and food or common setting) were reported to CDC. These multistate outbreaks accounted for 3% (120 of 4,163) of all reported foodborne outbreaks, but were responsible for 11% (7,929 of 71,747) of illnesses, 34% (1,460 of 4,247) of hospitalizations, and 56% (66 of 118) of deaths associated with foodborne outbreaks. Salmonella (63 outbreaks), Shiga toxin-producing E. coli (34), and Listeria monocytogenes (12) were the leading pathogens. Fruits (17), vegetable row crops (15), beef (13), sprouts (10), and seeded vegetables (nine) were the most commonly implicated foods. Traceback investigations to identify the food origin were conducted for 87 outbreaks, of which 55 led to a product recall. Imported foods were linked to 18 multistate outbreaks.Multistate foodborne disease outbreaks account for a disproportionate number of outbreak-associated illnesses, hospitalizations, and deaths relative to their occurrence. Working together, food industries and public health departments and agencies can develop and implement more effective ways to identify and to trace contaminated foods linked to multistate outbreaks. Lessons learned during outbreak investigations can help improve food safety practices and regulations, and might prevent future outbreaks.
Judge orders that teenager with narcolepsy be allowed to try sodium oxybate
Authors: Clare Dyer
Journal: BMJ (2016)

A High Court judge has ordered a three month trial of sodium oxybate for a 17 year old girl with narcolepsy and cataplexy, after ruling that NHS England had incorrectly applied its policy on exceptional drug funding when it turned her down.

“S,” whose identity is protected by an anonymity order, and her family had been trying for two years to obtain the drug after the drugs normally used in the NHS for narcolepsy failed to control the condition, which was severely affecting her life.

Mr Justice Collins delivered his judgment on 15 June, but at the end of the hearing on 4 May he ordered the three month trial of the drug, which costs £13 000 (€16 000; $18 000) …
Home care visits should be at least 30 minutes long, NICE says
Authors: Ingrid Torjesen
Journal: BMJ (2015)

Most home care visits should be at least half an hour long to enable carers to provide the personalised and dignified care that elderly patients need when being supported to stay in their own home, says a guideline on social care services from the National Institute for Health and Care Excellence (NICE).1

Shorter visits would be appropriate only rarely, said the finalised guideline on home care, published on 23 September. This might be when the visit is part of a wider package of support, made by a carer who is known to the patient, or made to complete a specific time limited task, such as checking that a medicine has been taken or that a person is safe and well.

The NICE guideline said that …
To-day's Drugs
Authors: E G BYWATERS, F D HART, J D BRACKENRIDGE
Journal: BMJ (1965)

Could we begin with a short discussion of the clinical course of the disease ?Dr. Hart ?Dudley Hart: It's a long, chronic, relapsing, progressive disease.This means you have to give a lot of time to the patient as a person, more than if there was a simple straightforward treatment that would give you the therapeutic results straight away.-Unlessyou effect this rapport with the patient, unless you go into every detail of her life, she is, therapeutically speaking, rather neglected.Chairman: Do you distinguish a definite acute stage of the disease ?Dudley Hart: Not really.There are various shades of acuity.Some cases are very acute; others fizzle out.
The Cost-Effectiveness of Preexposure Prophylaxis for HIV Prevention in Men Who Have Sex with Men in the United States
Authors: Jessie L. Juusola, Margaret L. Brandeau, Douglas K. Owens, Eran Bendavid
Journal: Annals of Internal Medicine (2012)

Background
In a recent randomized controlled trial, daily oral preexposure chemoprophylaxis (PrEP) was shown to be effective for HIV prevention in men who have sex with men (MSM). The United States Centers for Disease Control and Prevention (CDC) recently provided interim guidance for PrEP use among MSM who are at high risk for acquiring HIV. Previous studies failed to reach a consistent estimate of its cost-effectiveness.
Case 2-1994: Tricuspid Regurgitation
Authors: R H Stables, S J Brecker
Journal: New England Journal of Medicine (1994)

1477 grafts, bone and periosteal transplantations, grafts of whole joints, &c.),I thought of doing the same with the ureter- in other words, of performing ureteral auto-transplantations.The number of these experiments as yet made is too small to allow me to give a definite answer on the practical use of ureteral auto-transplantations, still I think I may call the results satisfactory.I hope to be able later to prove them on a larger scale and to confirm them with the histological examination.
Abstract 17122: Human iPS Cell-derived 3D Engineered Cardiac Tissue Including Cardiomyocytes and Multiple Vascular Lineages for Cardiac Regeneration
Authors: Hidetoshi Masumoto, Takeichiro Nakane, Joseph P Tinney, Fangping Yuan, Fei Ye, William J Kowalski, Ryuzo Sakata, Jun K Yamashita, Bradley B Keller
Journal: Circulation (2015)

Background: Three-dimensional (3D) engineered cardiac tissues (ECTs) are a robust platform technology to investigate cardiovascular (CV) cell function and provide an excellent microenvironment for tissue implantation and cardiac repair. We generated 3D ECTs using cardiomyocytes (CMs), endothelial cells (ECs), and vascular mural cells (MCs) efficiently differentiated from human iPS cells (hiPSCs). Methods &amp; Results: We employed 3 different monolayer culture-based differentiation protocols: 1) CM+EC protocol: mesoderm induction followed by VEGF (mes+VEGF) produced a distribution of 61.8±8.0% cTnT + -CMs, 19.4±9.1% VE-cadherin + -ECs, and 1.7±2.0% PDGFRβ + -MCs, (n=26, day15); 2) CM+MC protocol: mes+Dkk1 to induce CMs and MCs; and 3) MC protocol: exclusive induction of MCs. We collected the cells on differentiation day 15 and mixed them to generate 3 classes of ECTs composed of different CV cell population patterns: 1). CM+EC; 2). CM+MC, and 3). CM+EC+MC. We seeded the each cell mixture in a collagen/Matrigel mixture to form spontaneously beating ECTs. In vitro force measurement analysis showed that CM+EC+MC ECTs possessed the highest maximum capture rate (4.6±0.6 Hz, P&lt;0.0001) and lowest excitation threshold (1.2±0.3 V/cm, P&lt;0.01) indicating that incorporation of vascular cells augmented tissue maturation and function. We confirmed more preferential alignment of CMs to the ECT long axis in ECTs with MCs. Transmission electron microscopy revealed that incorporation of MCs increased CM sarcomeric structure. Incorporation of both ECs and MCs led to vasculature formation within ECTs during 14 days of in vitro culture. These results indicate that incorporation of vascular cells accelerated tissue structural maturation. Next CM+EC+MC ECTs were implanted onto infarcted athymic rat hearts. Echocardiogram revealed a significantly higher cardiac output at 4 weeks after implantation compared to that of sham-operated rats (137±23 vs 95±23 mL/min, P&lt;0.05). Immunostaining 4 weeks after implantation showed epicardial engraftment of human cells as a regenerated myocardium vascularized both by graft and host-derived vasculature. Conclusion: HiPSC-derived ECTs including vascular cells showed novel properties relevant for clinical translation.
Protective effects of imipramine maintenance treatment in panic disorder with agoraphobia
Authors: M Mavissakalian, J M Perel
Journal: American Journal of Psychiatry (1992)

This study was designed to assess and compare the differential relapse rates of patients with panic disorder and agoraphobia after discontinuation of acute treatment (6 months) or acute plus maintenance treatment (18 months) with imipramine.Sixteen patients with panic disorder and agoraphobia who had shown marked and stable response to 6 months of acute imipramine treatment and a comparable group of 14 patients who had been in remission during an additional year of half-dose imipramine maintenance treatment entered a 3-month, double-blind discontinuation study followed by a 3-month drug-free period. Assessments of the patients were made according to operationalized response/relapse criteria, and plasma drug concentrations were monitored.Survival analysis revealed significantly different cumulative probabilities of continued response 6 months after discontinuation of imipramine treatment between the patients who had received only acute treatment and those who had received acute and maintenance treatment.The results support the hypothesis that successful imipramine maintenance treatment of patients with panic and agoraphobia can have protective effects against relapse, at least in the first 6 months after the maintenance treatment period.
Letter to the editor. Group A streptococcal infections during the seasonal influenza outbreak 2010/11 in South East England
Authors: P Parola, P Colson, G Dubourg, M Million, R Charrel, P Minodier, D Raoult
Journal: Eurosurveillance (2011)

Preview this article: Letter to the editor. Group A streptococcal infections during the seasonal influenza outbreak 2010/11 in South East England, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/11/art19816-en-1.gif
Melanomas and Mechanical Stress Points on the Plantar Surface of the Foot
Authors: Akane Minagawa, Toshikazu Omodaka, Ryuhei Okuyama
Journal: New England Journal of Medicine (2016)

To the Editor: Sun exposure is widely recognized as the main causative factor in cutaneous melanoma. However, melanomas also emerge in areas of the skin (such as palmoplantar surfaces) that are not exposed to the sun. Genetic analyses indicate that melanomas in sun-exposed skin are frequently associated with oncogenic BRAF mutations that are largely absent from palmoplantar lesions.1 These findings suggest that different pathogenic processes may be at work.2 Here we report on a series of patients with melanomas that developed in areas of plantar surfaces that had the most mechanical stress. We retrospectively collected data on 123 patients (54 . . .
Recent Developments in the Transparent-Chamber Technique as Adapted to the Mouse
Authors: Algire, Glenn H., Legallais, Frances Y.
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article Recent Developments in the Transparent-Chamber Technique as Adapted to the Mouse Get access Glenn H. Algire, Glenn H. Algire Search for other works by this author on: Oxford Academic PubMed Google Scholar Frances Y. Legallais Frances Y. Legallais National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 225–253, https://doi.org/10.1093/jnci/10.2.225 Published: 01 October 1949 Article history Received: 03 May 1949 Published: 01 October 1949
Vascular Tumors Induced by Polyoma Virus in Pregnant Rats 2
Authors: M. Vandeputte, G. Meyer, H. Sobis
Journal: JNCI Journal of the National Cancer Institute (1976)

Female R rats mated with an R male and inoculated in utero with polyoma virus after "fetectomy" developed tumors. These tumors originated in the uterus and were of fetal origin (visceral yolk sac). Histologically, they were hemangiomas or hemangiosarcomas. The latter were transplantable and grew in tissue culture. Infectious polyoma virus could not be isolated from the tumor cells kept as transplantable lines or cultured in vitro. However, the tumor cells were positive for the polyoma-specific surface antigen, polyoma tumor-specific transplantation antigen(s), and polyoma nuclear T antigen.
Antibodies to Bladder-Tumor-Associated Antigens as Prognosis Probes in the Flow-Cytometric Analysis
Authors: A Hijazi, A Caratero, P Rischmann, J C Bes, D Chopin, J C Laurent, C Mazerolles, G Kassar, J P Sarramon, C Caratero
Journal: European Urology (1993)