tbuckley/cabot-search huggingface dataset:
Discrepant Expression Between mRNA and Protein of HTLV-I Basic Leucine Zipper Factor (HBZ) Makes HTLV-I Infected CD4 Lymphocytes and Adult T Cell Leukemia Cells Less Susceptible to HBZ-Specific Cytotoxic T Lymphocytes
Authors: Koichiro Suemori, Hiroshi Fujiwara, Toshiki Ochi, Masao Matsuoka, Jean Michel Mesnard, Masaki Yasukawa
Journal: Blood (2008)
AB0792 Knowledge about Osteoporosis and It's Risk Factors among Elderly Participants of Healthy Aging Academy
Authors: O. Brzezinska-Pawlowska, T. Budlewski, A. Wardzynska, A. Lewandowska-Polak, M. Kowalski, J. Makowska
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Osteoporosis and osteoporotic fractures are among the major problems of elderly population. Although deaths related to bone disease usually have indirect causes it is assessed that approximately 20% patients dies due to complications within first year after hip fracture and another 30% need permanent care. Some of the risk factors of osteoporotic fracture can be modified by lifestyle (diet, habits, exercise) intervention. To introduce this modifications elderly people need to be aware of the burden, risk factors and preventive measures of osteoporosis. Healthy Aging Academy is an initiative of Healthy Aging Research Center at Medical University of Lodz, which one of the aims is to educate local community of elderly people. <h3>Objectives</h3> The aim of the study was to assess the knowledge of elderly patients about osteoporosis, its risk factors, prevention measures and available treatment. <h3>Methods</h3> The study group included 177 students (34 men and 143 women, mean age 69±10 years old) of Healthy Aging Academy. Students were asked to answer 22 questions grouped in 4 domains: questions regarding symptoms and burden of osteoporosis (6 questions), risk factors (8 questions), preventive measures (5 questions) and treatment (3 questions). <h3>Results</h3> In total 177 participants filled questionnaire. The mean percentage of correct answers was 63±13% (range from 31% to 82%). The mean percentage of correct answers in the group of questions on symptoms and burden of osteoporosis was 54±14±13%. The mean percentage of correct answers on risk factors, preventive measures and treatment was 84±22%, 63±18% and 53±25% respectively. It has to be noticed that only 1/3 patients were aware about prevalence of osteoporosis and were convinced that bone pain is a symptom of osteoporosis preceding fracture. The sources of vitamin D and calcium were correctly identified only by 62% and 70% of students. <h3>Conclusions</h3> Despite fact that our questionnaire was filled by group of relatively well educated and active elderly a significant proportion of subjects did not present adequate knowledge on treatment and preventive measures in osteoporosis. <h3>References</h3> Qi BB, Resnick B, Nahm ES. Reliability and validity of the revised Osteoporosis Knowledge Test.J Nurs Meas. 2014;22(2):342–56. Díaz-Correa LM, Ramírez-García LM, Castro-Santana LE, Vilá LM. Osteoporosis knowledge in patients with a first fragility fracture in Puerto Rico. Bol Asoc Med P R. 2014;106(1):6–10. Levinson MR, Leeuwrik T, Oldroyd JC, Staples M. A cohort study of osteoporosis health knowledge and medication use in older adults with minimal trauma fracture. Arch Osteoporos. 2012;7:87–92. <h3>Acknowledgement</h3> The authors are partially supported by the Healthy Ageing Research Centre project (REGPOT-2012–2013–1,7FP). <h3>Disclosure of Interest</h3> None declared
The Anti-Proliferative Effects of Tricyclic Coumarin GUT-70 as An Hsp90 Inhibitor In Mantle Cell Lymphoma
Authors: Linhua Jin, Shinya Kimura, Yixin Zhou, Junya Kuroda, Hiroya Asou, Toshiya Inaba, Takashi Miida, Marina Konopleva, Michael Andreeff, Yoko Tabe
Journal: Blood (2010)
Choledochal cyst: a future indication for peroral choledochoscopy?
Authors: Rosa Coelho, Pedro Pereira, Filipe Vilas-Boas, Pedro Moutinho-Ribeiro, Rui Gaspar, Elisabete Rios, Guilherme Macedo
Journal: Endoscopy (2016)

A 31-year-old man with no medical history was admitted to the emergency department following 3 days of abdominal pain and jaundice. The laboratory work-up revealed elevated levels of bilirubin (9.2 mg/dL; direct 6.5 mg/dL) and C-reactive protein (30 mg/dL).
Detection of Mutations in SF3B1 in Chronic Lymphocytic Leukaemia Patients By Reverse Transcription (Rt) Polymerase Chain Reaction and High Resolution Melt Curve Analysis, an Alternative Approach to Next Generation Sequencing for Routine Molecular Diagnostic Laboratories?
Authors: Fiona M Quinn, Deirdre Waldron, David O'Brien, Johanna Kelly, Kathleen Scott, Amjad Hayat, Elisabeth A. Vandenberghe
Journal: Blood (2015)
Pathological and Genetic Characterization of Bilateral Adrenomedullary Hyperplasia in a Patient with Germline MAX Mutation
Authors: Pauline Romanet, Carole Guerin, Pascal Pedini, Wassim Essamet, Frédéric Castinetti, Fréderic Sebag, Philippe Roche, Alberto Cascon, Arthur S. Tischler, Karel Pacak, Anne Barlier, David Taïeb
Journal: Endocrine Pathology (2016)
Peripheral Blood Stem Cell (PBSC) Harvest Is More Expensive Following Bortezomib-Based Therapy in Multiple Myeloma (MM), Related to Increase Number of Days of Collect.
Authors: Matthieu Barthelemy, Florence Boulanger, Houria Debarri, Laurent Pascal, Pierre Samarcq, Colette Cossement, Jean-Pierre Jouet, Thierry Facon, Ibrahim Yakoub-Agha, Xavier Leleu
Journal: Blood (2009)
Siltuximab Treatment Increases Hemoglobin (Hb) Levels: Preliminary Results From a Prospective Phase 1 Study In Refractory Solid Tumors
Authors: R. Kurzrock, E. Angévin, S. Cohen, J. Van Laethem, B. Rijnbeek, J. Vermeulen, B. Tromp, W. Li, M. Reddy, M. Cornfeld, J. Tabernero
Journal: Blood (2010)
Timing of G-CSF Injection for Effective Autologous Stem Cell Collection
Authors: Jeong-Eun Kim, Cheolwon Suh, Yunsuk Choi, Eun Kyoung Kim, Byeong Seok Sohn, Inkeun Park, Dok Hyun Yoon, Changhoon Yoo, Geundoo Jang, Shin Kim, Dae Ho Lee, Sang -We Kim, Jung Shin Lee
Journal: Blood (2008)
The Target Receptor Siglec-3 (CD33) Is Expressed on AML Stem Cells in a Majority of All Patients with AML.
Authors: Alexander W. Hauswirth, Stefan FLorian, Maria-Theresa Krauth, Gerit-Holger Schernthaner, Edgar Selzer, Volker Wacheck, Dieter Printz, Gerhard Fritsch, Karl Sotlar, Wolfgang R. Sperr, Peter Valent
Journal: Blood (2005)
AB0718 Is There A Risk of Serious Rhythm and Conduction Disturbances, Requiring The Installation of A Pacemaker, in Patients with Spondyloarthritis?
Authors: S. Lapshina, M. Mangusheva, F. Chuvashaeva, A. Nigmatyanova, S. Eremin, L. Myasoutova
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> There is a lot of conflicting data about the defeat of the cardiovascular system in patients with spondyloarthritis (SpA). <h3>Objectives</h3> Rate the frequency of pacemakers setting in patients with SpA compared with the frequency of pacemakers implanted in the population <h3>Methods</h3> A database of patients with established heart pacemakers in 2013–2014 years, residing in the territory of the Tatarstan Republic was analyzed, the results correlated with the number of population. The frequency of cardiac pacemakers establishing the Tatarstan Republic is 2 per 10,000 population. The population of Tatarstan Republic in 2014 - 3,855,258 people, of whom at the age of 18 to 50 years - 1,831,719 people. 2958 patients with SpA are observed in Rheumatology clinics in Tatarstan, 2355 from them - with ankylosing spondylitis (AS). <h3>Results</h3> Young working age patients with implanted pacemakers without heart disease history were selected from the database. Those aged 18 to 50 years - 123 people (0.7 per 10,000 population), of whom 59 (47.9%) had congenital heart disease and conduction abnormalities, 5 (4.1%) patients had rheumatic disorders, (2 (1.6%) - a history of acute rheumatic fever, 3 (2.4%) - SpA. Among patients with an established diagnosis of SpA, AS was established in 1 person, in 2 diagnosis of SpA was set retrospectively: in the history of the disease low back pain was found and further examination was conducted. Thus, the frequency of cardiac pacemakers implanted in patients with SpA in Tatarstan is 0.1% or 10 cases per 10,000 patients, and 0.04% or 4 cases per 10,000 in patients with AS. <h3>Conclusions</h3> In patients with SpA there is a risk of serious rhythm and conduction disturbances, in some cases requiring the establishment of a permanent pacemaker. The frequency of pacemaker implantation is higher than in the whole population. <h3>Disclosure of Interest</h3> None declared
Evidence for CD34+ Hematopoietic Progenitor Cell Involvement in Acute Myeloid Leukemia with NPM1 Gene Mutation: Implications for the Cell of Origin
Authors: Maria Paola Martelli, Valentina Pettirossi, Elisabetta Bonifacio, Federica Mezzasoma, Nicla Manes, Debora Cecchini, Maruska Capanni, Ilaria Gionfriddo, Arcangelo Liso, Roberta Pacini, Manola Carini, Giorgina Specchia, Massimo F Martelli, Brunangelo Falini
Journal: Blood (2008)
Influence of Environment on Mammary Cancer in Mice
Authors: Howard B. Andervont
Journal: JNCI Journal of the National Cancer Institute (1944)

Influence of Environment on Mammary Cancer in Mice Get access Howard B. Andervont Howard B. Andervont principal biologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 6, June 1944, Pages 579–581, https://doi.org/10.1093/jnci/4.6.579 Published: 01 June 1944
THU0079 HDL, IGG anti-HDL Antibodies and PON1 Axis in Rheumatoid Arthritis Patients: A New Target for CV Disease
Authors: J. Rodríguez-Carrio, R. Lόpez-Mejías, M. Alperi-Lόpez, P. Lόpez, F.J. Ballina-García, M.Ά. González-Gay, A. Suárez
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> High Density Lipoproteins (HDL) seem to develop cardioprotective functions beyond the reverse cholesterol transport, thus pointing to their antioxidant activity as a crucial player. Paraoxonase 1 (PON1) is a HDL-associated antioxidant enzyme which has an important role in avoiding lipid oxidization. Although genetic polymorphisms are known to modulate PON1 activity, its involvement in cardiovascular disease (CVD) in Rheumatoid Arthritis (RA) is controversial, suggesting that other factors may modulate its function. <h3>Objectives</h3> since anti-HDL antibodies have been related to an impaired lipid profile and CVD in RA, we aimed to evaluate the associations between PON1 activity, anti-HDL antibodies and CVD in RA according to PON1 rs662 genetic variants. <h3>Methods</h3> serum PON1 activity, using paraoxon as substrate, and IgG anti-HDL antibodies were quantified in 212 RA patients and 110 healthy controls (HC). The PON1 rs662 genotype (Q&gt;R) was determined with TaqMan probes. An additional group of 13 biologic-naïve RA patients was prospectively followed for three months. <h3>Results</h3> PON1 activity was decreased in RA compared to HC (p=0.005). PON1 rs662 variants influenced serum PON1 activity in both groups, QQ homozygotes exhibiting the lowest activity. Distribution of genotypes did not differ between groups (p=0.215) and Hardy-Weinberg equilibrium was observed in both populations. Interestingly, PON1 activity was not associated with disease activity, ESR or CRP. A multivariate ANOVA analysis confirmed an independent role of both rs662 (p&lt;0.0001) and anti-HDL antibodies (p=0.026) on PON1 activity, but differences were noted when patients were stratified by genotypes. Anti-HDL antibodies were associated with an impaired PON1 activity (p=0.010), decreasing HDL levels (r=-0.680, p&lt;0.001) and higher prevalence of CV events in univariate and multivariate models in patients carrying the QQ genotype, but not in their QR or RR counterparts. Finally, change in anti-HDL antibodies upon TNFα-blockade independently predicted improved PON1 activity (B [95% CI], p: -0.369 [-0.669, -0.069], p=0.024) after adjusting by clinical response, change in ESR and change in HDL levels. <h3>Conclusions</h3> PON1 activity is impaired in RA in association with rs662 status and anti-HDL antibodies. The presence of anti-HDL antibodies in patients with the low activity genotype was correlated with a decreased PON1 function and associated with a higher prevalence of CV events in these patients. Therefore, anti-HDL antibodies are crucial mediators to understand the link between rs662 polymorphism and CVD. <h3>Disclosure of Interest</h3> None declared
Higher Expression of Suppressor of Cytokine Signaling1 (SOCS1) in the Bone Marrow Is an Unfavorable Prognostic Factor in Adult Patients with De Novo Acute Myeloid Leukemia
Authors: Cheng-Hong Tsai, Hwei-Fang Tien, Hsin-An Hou, Wen-Chien Chou, Yan-Jun Lai, Yuan-Yeh Kuo, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Shang-Ju Wu, Woei Tsay, Yao-Chang Chen, Mei-Hsuan Tseng, Chi-Fei Huang
Journal: Blood (2014)
Firearm Violence
Authors: Robert Steinbrook, Rachel J. Stern, Rita F. Redberg
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Impact Of Rituximab Maintenance Schedule On Prognosis In First Line Treatment Of Follicular Lymphoma. Retrospective Analysis From Czech Lymphoma Group (CLG) Database
Authors: Andrea Janikova, Zbynek Bortlicek, Vit Campr, Leos Kren, David Belada, Vit Prochazka, Robert Pytlik, Jan Pirnos, Milan Matuska, Tomas Papajik, Heidi Mocikova, Samuel Vokurka, Jiri Mayer, Marek Trneny
Journal: Blood (2013)
Reduced Intensity Conditioning Regimen for Allografting Following Cytoreductive Autografting in Relapsed/Resistant Hodgkin’s Lymphoma.
Authors: Michele Carella, Germana Beltrami, Maria T. Corsetti, Mario M. Greco, Potito Scalzulli, Nicola Cascavilla, Pellegrino Musto, Antonio La Sala, Matteo Dell’Olio, A.M. Carella
Journal: Blood (2004)
Bortezomib and BEAM-Rituximab Reduced-Intensity Conditioning for High-Risk Lymphoma Patients Who Are Not Eligible for Nonmyeloablative Allogeneic Stem Cell Transplantation
Authors: Issa F. Khouri, Saliba M. Rima, Francesco Turturro, Martin Korbling, Celina Ledesma, Gabriela Rondon, Amin M. Alousi, Paolo Anderlini, Qaiser Bashir, Stefan O. Ciurea, Chitra M. Hosing, Uday R. Popat, Yasmeen Charafeddine, Yasuhiro Oki, Luis E Fayad, Richard E. Champlin
Journal: Blood (2012)
Prognostic Significance of Blasts with/without Pleiocytosis in the Cerebro-Spinal Fluid (CSF) of Children with Acute Lymphoblastic Leukemia (ALL) Treated without Cranial Irradiation: Results of European Organization for Research and Treatment of Cancer (EORTC) Children Leukemia Group Study 58881.
Authors: Nicolas Sirvent, Stefan Suciu, Xavier Rialland, Alain Robert, Francoise Mazingue, Frederic Millot, Barbara De Moerloose, Alice Ferster, Pierre Rohrlich, Lucilia Norton, Brigitte Lescoeur, Marie-Francoiseçoise Dresse, Patrick Lutz, Liliana Baila, Catherine Behar, Yves Bertrand, Jacques Otten
Journal: Blood (2006)
Conservative treatments for greater trochanteric pain syndrome: a systematic review
Authors: Paul A Barratt, Nathan Brookes, Annalisa Newson
Journal: British Journal of Sports Medicine (2016)

Greater trochanteric pain syndrome (GTPS) can have a significant effect on quality of life.To evaluate the conservative treatments for GTPS.This systematic review assessed risk of bias using the Cochrane Risk of Bias Tool and Cochrane Risk of Bias Tool for non-randomised studies of interventions.On 13 January 2016, a comprehensive search was conducted, with no limit on year of publication for relevant studies in the MEDLINE, CINAHL, AMED and EMBASE databases.English language randomised controlled trials, case-control or cohort studies reporting outcome data for conservative treatments for adults having a diagnosis of GTPS, or trochanteric bursitis, were included.8 studies (n=696) were eligible for inclusion in the review; corticosteroid injections (CSI) (n=6), shockwave therapy (n=2), home training (n=1) and orthotics (n=1). Based on pain, CSI demonstrated superior outcomes for up to 3 months compared with home training, radial shockwave therapy (RSWT) and usual care, in 4 studies demonstrating either a low or moderate risk of bias. Fluoroscopy-guided injections failed to show additional benefit. RSWT and home training had limited evidence. No conclusions can be drawn regarding the use of orthotics due to the serious risk of bias and methodological flaws within that study.This review demonstrates a paucity of high-quality research for the conservative treatments of GTPS. The risk of bias was low in only one study, demonstrating no additional benefit with fluoroscopically guided injections. Risk of bias in all remaining studies was varied. Standardisation of diagnostic criteria and outcome measures is essential to enable more powerful analysis.
FRI0520 Comparison of 18F-Fluoro-Deoxyglucose Positron Emission Tomography and Computed Tomography Angiography for The Diagnosis of Giant Cell Arteritis: A Prospective, Case-Control Study
Authors: D. Lariviere, K. Benali, B. Coustet, N. Pasi, J.-F. Alexandra, P. Dieude, T. Papo, K. Sacre
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Diagnosis of giant cell arteritis (GCA) is still a challenge. 18F-fluoro-deoxyglucose positron emission tomography scan (FDG-PET) and computed tomography angiography (CTA) are promising imaging techniques for the detection of GCA <h3>Objectives</h3> To compare the diagnostic performance of FDG-PET and CTA in patients with giant cell arteritis (GCA). <h3>Methods</h3> FDG-PET and CTA were acquired in 24 consecutive patients in whom temporal artery biopsy (TAB) was performed for suspected GCA. Results of FDG-PET and CTA were compared with the final clinical diagnosis based on a) the American College of Rheumatology GCA criteria set, b) clinical judgment including outcome under corticosteroids, and c) the absence of an alternative diagnosis after a 6 months follow-up. Sensitivity, specificity, and positive and negative predictive values (PPV, NPV) were calculated for each method. <h3>Results</h3> Fifteen of the 24 patients (62.5%) were ultimately diagnosed as having GCA. Strong FDG uptake in large vessels was found in 10 patients who all had GCA. Mean maximal standard uptake values (SUVmax) per patient measured at all the arterial territories were of 3.7 [range: 2.8–4.7]. FDG uptake was negative in 14 patients including 9 and 5 patients without and with GCA, respectively. Mural thickening suggestive of aortitis or branch vessel arteritis was observed on CTA in 11 patients with and 2 patients without GCA. No mural thickening was observed in 11 patients including 7 patients without and 4 patients with GCA. Overall, sensitivity of FDG-PET and CTA was 66.7% and 73,3%, respectively; specificity was 100% and 84.6%, NPV was 64.3% and 64.6%, and PPV was 100% and 84.6%, respectively. <h3>Conclusions</h3> Both FDG-PET and CTA have a strong diagnostic yield for the diagnosis of GCA. FDG-PET appeared to have a higher PPV as compared to CTA and may be the preferred noninvasive technique to evaluate patients with suspected GCA. <h3>Disclosure of Interest</h3> None declared
Revisiting the morbid genome of Mendelian disorders
Authors: Mohamed Abouelhoda, Tariq Faquih, Mohamed El-Kalioby, Fowzan S. Alkuraya
Journal: Genome biology (2016)

The pathogenicity of many Mendelian variants has been challenged by large-scale sequencing efforts. However, many rare and benign "disease mutations" are difficult to analyze due to their rarity. The Saudi Arabian variome is enriched for homozygosity due to inbreeding, a key advantage that can be exploited for the critical examination of previously published variants. We collated all "disease-related mutations" listed in the Human Gene Mutation Database (HGMD) and ClinVar, including "variants of uncertain significance" (VOUS). We find that the use of public databases including 1000 Genomes, ExAC, and Kaviar can reclassify many of these variants as likely benign. Our Saudi Human Genome Program (SHGP) can reclassify many variants that are rare in public databases. Furthermore, SGPD allows us to observe many previously reported variants in the homozygous state and our extensive phenotyping of participants makes it possible to demonstrate the lack of phenotype for these variants, thus challenging their pathogenicity despite their rarity. We also find that 18 VOUS BRCA1 and BRCA2 variants that are listed in BRCA Exchange are present at least once in the homozygous state in patients who lack features of Fanconi anemia. Reassuringly, we could reciprocally demonstrate that none of those labeled as "pathogenic" were observed in the homozygous statue in individuals who lack Fanconi phenotype in our database. Our study shows the importance of revisiting disease-related databases using public resources as well as of population-specific resources to improve the specificity of the morbid genome of Mendelian diseases in humans.