tbuckley/cabot-search huggingface dataset:
AB0258 Predictors of Maladaptive Coping Strategies in Patients with Rheumatoid Arthritis
Authors: E.V. Muslimova, S.P. Yakupova, E.Z. Yakupov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The use of maladaptive coping strategies in patients with rheumatoid arthritis (RA) associates with disability, psychological distress and high pain intensity. Identifying the predictors of maladaptive coping could help physicians in revealing the target group of patients which requires the conducting of the cognitive - behavioral therapy. <h3>Objectives</h3> To identify the predictors of maladaptive coping strategies in patients with RA. <h3>Methods</h3> The cross-sectional survey included 124 patients with RA (male to female ratio 4,4:1), mean age 49,4 [44; 56] years, mean duration of disease ranged from 3 months to 41 years (10,8 [3,5;13]). RA diagnosis based on ACR/EULAR criteria of 2010. Patients completed the following questionnaires: Visual - Analogue Scale (VAS), Beck Depression Inventory, State-Trait Anxiety Inventory, McGill Pain Questionnaire, The Pain Catastrophizing Scale. To identify the predictors of maladaptive strategies a logistic regression model was constructed (R2=0,694, p&lt;0,001, β – is a standard indicator characterizing the strength of variable influence). <h3>Results</h3> Among the clinical parameters that significantly influenced to the choice of patients were the level of pain intensity (β=0,4), frequency of NSAID use (β =0,2), disability index (β=0, 6), disease duration (β= -0,3), the duration of morning stiffness (β= -0,3), the presence of systemic manifestations (β =-0,3), pain catastrophizing level (β=0,5), depression (β= -0.2), erythrocyte sedimentation rate (ESR) (β= -0,2), severe pain registers (β=1,2) and a large amount of descriptors (β= -1) selected on McGill Pain Questionnaire. <h3>Conclusions</h3> The intensity of pain, frequency of NSAID use, RA duration, the duration of morning stiffness, the presence of systemic manifestations along with the ESR, level of catastrophizing, depression, severe registers of pain intensity and a large amount of pain descriptors were significant predictors of maladaptive coping in patients with RA. The findings could provide an opportunity to distinguish the target group of patients with RA, who needs along with the standard therapy of RA the conducting of cognitive - behavioral therapy. <h3>Disclosure of Interest</h3> None declared
Endoscopic ultrasound-guided ERCP in the treatment of a Todani type-III cyst causing acute necrotizing pancreatitis
Authors: Benedetto Mangiavillano, Andrea Parodi, Massimo Conio
Journal: Endoscopy (2016)

Bile duct cysts are defined as dilatations of the extrahepatic or intrahepatic biliary tree. Biliary cysts are classified according to the Todani classification, which encompasses five types. They account for approximately 1 % of all benign biliary disease. The incidence of biliary cysts in Europe is 1 – 2 per 1 000 000. The Todani type-III cyst is rare and accounts for 2 % – 4 % of all Todani cysts. The risk of developing a cholangiocarcinoma ranges from 2.5 % to 28 %, and increases with age. Choledocholithiasis, cholelithiasis, hepatolithiasis, cholangitis, pancreatitis, and spontaneous cyst perforation have all been reported in these patients [1, 2].
PTH-261 Laparoscopic surgery for locally advanced sigmoid colon cancer: short and long-term clinical outcomes
Authors: T Yamanashi, T Sato, A Tsutsui, H Miura, N Ogura, M Naito, T Nakamura, M Watanabe
Journal: Gut (2015)

<h3>Introduction</h3> In recent years, the laparoscopic surgery for locally advanced colon cancer spread rapidly owing to the clinical trials in the world. Meanwhile, it is difficult to distinguish T4a and T4b in operations and the safety of laparoscopic surgery for T4 colon cancer is still not established. We validated the safety and the usefulness of laparoscopic surgery for T4 sigmoid colon cancer. <h3>Method</h3> The study group comprised 67 patients who underwent laparoscopic surgery for pT4 sigmoid colon cancer from 2005 through 2013, excluding ones with distant metastasis. There are 41 male patients (61.2%) and 26 female patients (38.8%). The mean age was 62 years old. pStages were II in 29 patients (43.3%), IIIB in 26 patients (38.8%), and IIIC in 12 patients (17.9%), respectively. The median follow-up was 60 months (14–122). We report short and long-term clinical outcomes. <h3>Results</h3> The operation time was 210 min (129–345). The blood loss was 10 ml (5–310). The postoperative hospital stay was 7 days (4–278). 66 patients (98.5%) were able to undergo R0 surgical resection. The suture failure occurred in 4 patients (6%), who underwent ileostomy. The 5-year and final recurrence-free survival (RFS) rates were 61.7% and 61.7%, respectively. Twenty-four patients (35.8%) had recurrence, and initial recurrence occurred in the peritoneum (n = 7), para-aortic region (n = 6), lung (n = 6), liver (n = 5), locoregional region (n = 5), and ovary (n = 1). The 5-year and final overall survival (OS) rates were 90.4% and 73.5%. Nine patients (13.4%) died of cancer progression. <h3>Conclusion</h3> Laparoscopic surgery for T4 sigmoid colon cancer provided good postoperative short-term outcomes. On the other hand, recurrence rates were slightly higher and there is still room for improvement in the long-term outcomes. <h3>Disclosure of interest</h3> None Declared.
Malaria in the WHO European Region (1971–1999)
Authors: G Sabatinelli, M Ejov, P Joergensen
Journal: Eurosurveillance (2001)

The number of autochthonous reported cases of malaria fell from 90 506 to 37 170 between 1996 and 1999 in the WHO European Region. There has been, however, an eight-fold increase in imported cases since the 1970s: 1500 cases were reported in 1972, 13 000 cases in 1999. France, Germany, Italy, and the United Kingdom are the west European countries with the largest numbers of cases.
Metabolic Effects of Phenethylbiguanide (DBI) on the Isolated Perfused Rat Heart
Authors: J R WILLIAMSON, R S WALKER, A E RENOLD
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation of a psychiatric clerkship by videotape
Authors: A T Meyerson, A Wachtel, J Thornton
Journal: American Journal of Psychiatry (1977)

The authors used a videotape-based objective examination ingeneral psychiatry to assess the clinical competence of medical students who had completed their third-year clerkship. The test has been shown to be a reliable, valid measure of clinical competence. Subjective faculty grading related positively to test scores. Students on one ward had significantly lower overall test scores, with particularly low scores on clinical judgement questions. However, faculty grades for these students were not significantly different. This suggests that the faculty was unable to assess the relative efficacy of its own teaching. The test can provide objective assessment of student clinical competence and is a means of program evaluation.
The physician's knowledge of psychotropic drugs: preliminary results
Authors: R M Gottlieb, T Nappi, J J Strain
Journal: American Journal of Psychiatry (1978)

A questionnaire about three commonly prescribed psychotropic drugs was administered to physicians and trainees in two specialties and to medical students. Psychiatrists and psychiatric residents had very low levels of knowledge about the physiology, pharmacology, and side effects of diazepam; their scores did not exceed those of medical residents or students. Trainees in internal medicine scored poorly regarding the diagnosis of depressive syndromes and the physiology and pharmacology of imipramine and amitriptyline, whereas psychiatrists performed well. The results of this preliminary study can provide guidelines for improving the teaching of psychopharmacology in general and the psychopharmacological treatment of the medically ill in particular.
P38 Matrix stiffness regulates proliferation, differentiation and chemotherapeutic responsiveness in hepatocellular carcinoma
Authors: T Gordon-Walker, J Schrader, D Benten, M Van Deemter, S J Forbes, R G Wells, J P Iredale
Journal: Gut (2010)

Introduction  The majority (80%) of hepatocellular carcinomas (HCC) develop within the context of advanced liver fibrosis and cirrhosis. Recent studies with ultrasound elastography have demonstrated that increased liver stiffness is a strong predictor of HCC.  Aim  To establish whether alterations in matrix stiffness regulate the phenotype and chemotherapeutic response of HCC cells.  Method  Experiments were conducted using a system of ligand-coated polyacrylamide gels of variable stiffness. Matrix stiffness (expressed as shear modulus) was modelled across a physiologically-relevant range (1–12 kPa), corresponding to values encountered in normal and fibrotic livers. Experiments were conducted in two HCC cells lines (Huh7/ HepG2).  Results  In each cell type, there was a consistent morphological response to changes in matrix stiffness. There was increased cell spreading on stiff gels in association with both stress-fibre and mature focal adhesion formation. Increasing matrix stiffness promoted cellular proliferation. The proliferative index (assessed by Ki67 staining) of Huh7 and HepG2 cells was 2.7-fold (p  Conclusion  HCC is a tumour that develops within an altered biomechanical niche. Increasing matrix stiffness regulates HCC mitogenic signalling, proliferation, differentiation and chemotherapeutic resistance. However, a soft microenvironment (as may be encountered by disseminated tumour cells) promotes stem cell characteristics following chemotherapy. This provides a possible explanation for the failure of systemic chemotherapy both in relation to treatment of primary HCCs and the eradication of disseminated tumour cells that give rise to metastases. The selective targeting of the cytoskeleton represents a potentially novel approach to the treatment of HCC.
Priorities for Improving Hearing Health Care for Adults
Authors: Frank R. Lin, William R. Hazzard, Dan G. Blazer
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lesson of the Week: Unsuspected Pneumocystis carinii pneumonia and vertically acquired HIV infection in infants requiring intensive care
Authors: R C Tasker, K Wilkinson, T J Slater, V Novelli
Journal: BMJ (1994)

<h3><b>Background</b></h3> Manual muscle tests (MMTs) are used in clinical settings to evaluate the function and strength (force-generating capacity) of a specific muscle in a position at which the muscle is believed to be most isolated from other synergists and antagonists. Despite frequent use of MMTs, few electromyographic evaluations exist to confirm the ability of MMTs to isolate rotator cuff muscles. <h3><b>Objective</b></h3> This study examined rotator cuff isolation during 29 shoulder muscle force tests (9 clinical and 20 generic tests). <h3><b>Design</b></h3> An experimental design was used in this study. <h3><b>Participants and Measurements</b></h3> Electromyographic data were recorded from 4 rotator cuff muscles and 10 additional shoulder muscles of 12 male participants. Maximal isolation ratios (mean specific rotator cuff muscle activation to mean activation of the other 13 recorded muscles) defined which of these tests most isolated the rotator cuff muscles. <h3><b>Results</b></h3> Three rotator cuff muscles were maximally isolated (obtained highest isolation ratios) within their respective clinical test groups (lateral rotator test group for the infraspinatus and teres minor muscles and abduction test group for the supraspinatus muscle). The subscapularis muscle was maximally isolated equally as effectively within the generic ulnar force and clinical medial rotation groups. Similarly, the supraspinatus and teres minor muscles were isolated equally as effectively in some generic test groups as they were in their respective clinical test groups. <h3><b>Limitations</b></h3> Postural artifact in the wire electrodes caused exclusion of some channels from calculations. The grouping of muscle force tests based on test criteria (clinical or generic tests and muscle action) may have influenced which groups most isolated the muscle of interest. <h3><b>Conclusions</b></h3> The results confirmed the appropriateness of 9 commonly used clinical tests for isolating rotator cuff muscles, but suggested that several other muscle force tests were equally appropriate for isolating these muscles.
Rapid treatment of acute psychosis
Authors: W H Anderson, J C Kuehnle, D M Catanzano
Journal: American Journal of Psychiatry (1976)

Twenty-four patients with acute functional psychoses were treated with intramuscular haloperidol in a three-hour period. There was almost complete remission of cardinal symptoms (thought disorder, hallucinations, and delusional activity) in this period for 11 patients. Acute dystonia, easily reversed, was the only significant side effect. The authors therefore suggest that outpatient management may be feasible and preferable in the treatment of some acute psychotic episodes.
Endometrial Sarcomas of the Uterus and Carcinosarcomas of the Submaxillary Salivary Gland in Castrated A × C Strain Female Rats Receiving &lt;italic&gt;N,N&lt;/italic&gt;-Fluorenyldiacetamide and Norethandrolone&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: M D REUBER
Journal: JNCI Journal of the National Cancer Institute (1960)

In 10 castrated female A × C rats receiving N,N-fluorenyldiacetamide (2FdiAA) and norethandrolone, 3 developed sarcomas of the uterus and 2 carcinosarcomas of the salivary glands. It appears that norethandrolone causes endometrial cystic hyperplasia which with 2-FdiAA leads to endometrial sarcomas of the uterus. The carcinosarcomas of the salivary gland did not develop in intact animals of either sex and may be related to the anabolic effects of norethandrolone. Salivary-gland tumors did not occur in similarly treated castrated male rats with or without norethandrolone. Neither tumors of the uterus nor salivary glands were observed in intact females given norethandrolone or in intact or castrated female rats given progesterone or testosterone. Hence, both the absence of the gonads and the presence of norethandrolone seem to be important in the induction of uterine sarcomas or salivary-gland carcinosarcomas in A × C rats fed 2-FdiAA.
THU0372 Incidence of Systemic Lupus Erythematosus (SLE) in a Population Based Cohort Using 1982, Revised 1997 ACR and 2012 SLICC Criteria
Authors: V. Sagar, C. Crowson, S. Amin, A. Makol, F. Ernste, T. Osborn, K. Moder, T.B. Niewold, H. Maradit-Kremers, V. Chowdhary
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with heterogeneous clinical phenotypes. Various classification criteria have been developed to identify patients with SLE for research studies. <h3>Objectives</h3> We used the 1982 American College of Rheumatology (ACR), revised 1997 ACR and the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria to estimate incidence of SLE in our predominantly white, population based cohort, from 1993-2005. <h3>Methods</h3> An incident SLE case was defined as an individual who fulfilled either 4 out of 11, 1982 or revised 1997 ACR SLE classification criteria or who met ≥4 SLICC criteria (with at least 1 clinical and 1 laboratory) or had biopsy proven lupus nephritis with positive ANA or anti-dsDNA (SLICC) and who had been a resident of the county for at least 1 year prior to first physician diagnosis of SLE. The incidence date was the date of fulfillment of the fourth criterion. Cases with isolated cutaneous lupus, drug- induced lupus and overlap diseases were excluded. Overall incidence and prevalence was age- and sex-adjusted to the 2000 US white population. <h3>Results</h3> There were 45 incident cases who met ACR (1982 and 1997) and SLICC criteria, 11 who met SLICC criteria only and one patient who met both SLICC and 1997 ACR but not 1982 ACR criteria. The age and sex adjusted incidence of SLE was higher at 3.6 per 100 000 by SLICC criteria than 2.9 per 100 000 by 1982 or 1997 ACR criteria, however this difference was not statistically significant (p=0.05, respectively). The incidence per 100000 in females was 5.8 by SLICC, 5.0 by 1982 ACR and 5.1 by 1997 ACR criteria (p=0.06); in men it was 1.02 per 100000 using SLICC and 0.5 by ACR 1982 and 1997 criteria (p=0.11). The average age of 42±17.6 years was not different in the SLICC cohort compared to 41±17.9 years in the 1982 and 1997 ACR cohort (p=0.24). The female to male ratio was 6:1 in patients fulfilling SLICC criteria and 10: 1 in those fulfilling ACR (1982 or 1997) however this did not reach statistical significance (p=0.06). The mean number of SLE criteria in the SLICC cohort were 5.3 (range 2-8) and 4.7 (range 4-7) in the ACR cohorts respectively. <h3>Conclusions</h3> The 2012 SLICC criteria may be more sensitive than 1982 and revised 1997 ACR criteria in identifying patients with SLE however larger studies in diverse populations are needed to validate these findings. <h3>Disclosure of Interest</h3> None declared
Spontaneous Pulmonary Tumor in the Rat: Report of a Lesion
Authors: Helen A. Horn, Harold L. Stewart
Journal: JNCI Journal of the National Cancer Institute (1952)

Spontaneous Pulmonary Tumor in the Rat: Report of a Lesion Get access Helen A. Horn, Helen A. Horn Special Research Fellow Laboratory of Pathology, National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Stewart Harold L. Stewart Chief Laboratory of Pathology, National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 4, February 1952, Pages 743–749, https://doi.org/10.1093/jnci/12.4.743 Published: 01 February 1952 Article history Received: 18 September 1951 Published: 01 February 1952
SAT0266 Very High Prevalence of Cardiac Disease in Ankylosing Spondylitis Patients
Authors: S.C. Heslinga, T. Konings, O. Kamp, M. Peters, Y. Smulders, I. van der Horst-Bruinsma, M. Nurmohamed
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Ankylosing spondylitis (AS) is associated with increased risk of cardiac disease, such as valvular regurgitation, conduction disturbances and decreased ventricular function [1]. However, contemporary data are not available and therefore we investigated the prevalence of cardiac manifestations in AS patients between 50 and 75 years old. <h3>Objectives</h3> To determine the prevalence of cardiac disease in older AS patients with and without a cardiovascular history. <h3>Methods</h3> We performed a cross sectional study in randomly selected AS patients between 50 and 75 years old. Patients were screened for cardiac disease using standard transthoracic echocardiography (TTE) that included two-dimensional, three-dimensional and M-mode echocardiography, spectral Doppler, color Doppler and tissue Doppler imaging. Systolic left ventricular (LV) dysfunction was defined as an ejection fraction &lt;50%. Diastolic LV dysfunction (DD) was graded into three categories: mild (grade I), pseudonormal (grade II) and restrictive (grade III). Valvular parameters and aortic diameters were evaluated according to the current echocardiographic guidelines <h3>Results</h3> Sixty-nine AS patients (18 females, 26%) with a mean age of 60±7 years and a mean disease duration of 22±13 years were included. 16 patients (23%) had a history of cardiovascular disease, including stroke (n=2), myocardial infarction (n=3), rhythm disorders (n=5), or a combination (n=6). Of all patients, 33% had DD grade I, 13% DD grade II and 0% DD grade III and 3 patients (4%) had systolic LV dysfunction. In patients without a history of cardiovascular disease, a new cardiac abnormality was found on TTE in 14 (20%) which required treatment or follow-up by a cardiologist: ventricular dysfunction (n=2), aortic (root) dilatation (n=7), valvular regurgitation (n=2), rhythm disorders (n=1), other (n=1) or a combination (n=1). <h3>Conclusions</h3> In patients with a long duration of AS, without a history of cardiac disease or symptoms, there is a high prevalence of cardiac manifestations, with high prevalences of LV dysfunction, valvular disease and aortic (root) dilatation. This high prevalence might ultimately translate into increased cardiovascular morbidity and mortality. Obviously, the potential clinical impact and effect on cardiovascular mortality remains to be determined. <h3>References</h3> Nurmohamed MT, van der Horst-Bruinsma I, Maksymowych WP. Cardiovascular and cerebrovascular diseases in ankylosing spondylitis: current insights. Curr Rheumatol Rep 2012 Oct;14(5):415-21. <h3>Acknowledgements</h3> This study was partially financed by the Dutch Arthritis Association, The Netherlands <h3>Disclosure of Interest</h3> None declared