tbuckley/cabot-search huggingface dataset:
DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster
Authors: Sladjana Zagorac, Sonia Alcala, Gustavo Fernandez Bayon, Tony Bou Kheir, Matthieu Schoenhals, Anna González-Neira, Mario Fernandez Fraga, Alexandra Aicher, Christopher Heeschen, Bruno Sainz
Journal: Cancer Research (2016)

Pancreatic ductal adenocarcinoma (PDAC) and other carcinomas are hierarchically organized, with cancer stem cells (CSC) residing at the top of the hierarchy, where they drive tumor progression, metastasis, and chemoresistance. As CSC and non-CSC share an identical genetic background, we hypothesize that differences in epigenetics account for the striking functional differences between these two cell populations. Epigenetic mechanisms, such as DNA methylation, play an important role in maintaining pluripotency and regulating the differentiation of stem cells, but the role of DNA methylation in pancreatic CSC is obscure. In this study, we investigated the genome-wide DNA methylation profile of PDAC CSC, and we determined the importance of DNA methyltransferases for CSC maintenance and tumorigenicity. Using high-throughput methylation analysis, we discovered that sorted CSCs have a higher level of DNA methylation, regardless of the heterogeneity or polyclonality of the CSC populations present in the tumors analyzed. Mechanistically, CSC expressed higher DNMT1 levels than non-CSC. Pharmacologic or genetic targeting of DNMT1 in CSCs reduced their self-renewal and in vivo tumorigenic potential, defining DNMT1 as a candidate CSC therapeutic target. The inhibitory effect we observed was mediated in part through epigenetic reactivation of previously silenced miRNAs, in particular the miR-17-92 cluster. Together, our findings indicate that DNA methylation plays an important role in CSC biology and also provide a rationale to develop epigenetic modulators to target CSC plasticity and improve the poor outcome of PDAC patients. Cancer Res; 76(15); 4546-58. ©2016 AACR.
PTH-289 The poor overall survival of right-sided colon cancer compared with left-sided colon cancers: a systematic review and meta-analysis
Authors: M Yahagi, K Okabayashi, H Hasegawa, M Tsuruta, T Kondo, T Shimada, M Matsuda, Y Yoshikawa, Y Asada, K Sugiura, Y Suzuki, Y Tajima, J Nakadai, Y Kitagawa
Journal: Gut (2015)

<h3>Introduction</h3> Right-sided colon cancers (RCC) and left-sided colon cancers (LCC) are of different embryological origins, and there are various differences between them. However, the survival difference has not been evaluated. The aim of the present study was to quantify the difference of prognosis between RCC and LCC by meta-analysis. <h3>Method</h3> PubMed and the Cochrane Library were searched during May 2014 for literature on right- versus left-sided colon cancers. The MeSH terms “colonic neoplasm” and the terms “prognosis” or “survival analysis” were combined with terms “left” and “right” or “sub site”. The effects of tumour locations on survival outcome (overall survival [OS] and cancer-specific survival [CSS]) were assessed. Hazard ratio (HR) was used as a surrogate for effect size, and random-effects meta-regression was applied as a method to evaluate the influences of covariates. Heterogeneity and publication bias were assessed. <h3>Results</h3> 15 studies (108,474 participants) which compared the prognosis of colon cancer according to tumour location were included. With respect to OS, patients with RCC had a significantly worse prognosis (HR = 1.14, 95% conﬁdence interval [CI]: 1.06 –1.22, p &lt; 0.01, I<sup>2</sup>= 41.82%) than those with LCC. Though, this tendency was not evident for CSS, which might be because CSS was evaluated by a small number of studies included in this analysis. Subgroup analyses demonstrated significant prognostic differences in Western countries (HR = 1.15, 95% CI: 1.08 – 1.23, p &lt; 0.01), a nationwide database (HR = 1.15, 95% CI: 1.05 – 1.27, p = 0.01), and a stage-adjusted analysis (HR = 1.14, 95% CI: 1.05 – 1.24, p &lt; 0.01). The test of funnel plot identified no publication bias. The source of heterogeneity was not identified in meta-regression. <h3>Conclusion</h3> Our findings indicate that tumour location is closely associated with prognosis in colorectal cancer patients, and those with RCC have a significantly worse prognosis than those with LCC in regards to OS. Therefore, RCC should be treated distinctively from LCC, and the establishment of standardised management for colon cancer by tumour location is needed. <h3>Disclosure of interest</h3> None Declared.
Endoscopic removal of a migrated and long-indwelling self-expandable metal stent
Authors: Qi-Shan Zeng, Hong-Lin Chen, Qin Liu, Hong-Ze Zeng, Qi-Ming Wang, Wei Liu, Bing Hu
Journal: Endoscopy (2015)

The removal of a biliary uncovered self-expandable metal stent (uSEMS) is difficult or even impossible when the stent has been indwelling for longer than a couple of weeks because of tissue ingrowth [1] [2]. A malfunctioning uSEMS may be removed with forceps, a snare, the invagination technique [3], or the stent-in-stent technique [2] [4]. We report the removal of a migrated uSEMS, placed in a patient's bile duct 10 years earlier for a biliary stricture that had developed after bile duct lithotomy.
Susceptibility of Agent-Free Inbred Mice and Their F&lt;sub&gt;1&lt;/sub&gt; Hybrids to Estrogen-Induced Mammary Tumors
Authors: Howard B. Andervont, Thelma B. Dunn, Harry Y. Canter
Journal: JNCI Journal of the National Cancer Institute (1958)

Agent-free mice of inbred strains C3H, BALB/c, RIII, DBA/2, I, and C57BL and their reciprocal F1 hybrids were tested for susceptibility to mammary tumors induced by the subcutaneous implantation of diethylstilbestrol-cholesterol pellets. Strain C3H mice, (BALB/c × C3H)F1 hybrids, and (RIII × C3H)F1 hybrids were the most susceptible to the hormone-induced tumors. The high incidence of tumors in these 3 groups of mice makes them suitable animals for use in experiments in which it is desirable to procure mammary tumors in the absence of the mammary-tumor agent. The morphologic types of the mammary tumors in mice of the present series were similar to those previously described. The histogenesis of the tumors in the present experiment, especially those in old male mice receiving large doses of estrogen, was different since the tumors usually arose within a focus of altered fibrocystic mammary tissue. A glioblastoma multiforme was found in one of the treated mice. No previous record of such a neoplasm has been found except in mice receiving chemical carcinogens intracerebrally.
Doctor Ross C. MacCardle: An Appreciation
Authors: E. V. Cowdry
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article Doctor Ross C. MacCardle: An Appreciation Get access E. V. Cowdry E. V. Cowdry Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 35, Issue 1, July 1965, Pages IV–V, https://doi.org/10.1093/jnci/35.1.IV Published: 01 July 1965
AB0465 Comparison of Abatacept Efficacy and Safety in Different Stages Rheumatoid Arthritis
Authors: K.A. Maria, G.V. Lukina, Y.A. Sigidin, E.S. Aronova, S.I. Glukhova, E.L. Luchihina, D.E. Karateev, E.L. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Although Abatacept (ABA) is widely used in treatment of RA. there isn9t enough data about its effectiveness in patients with early (ERA) and long-standing (LS) rheumatoid arthritis. <h3>Objectives</h3> To compare effect of ABA in patients (pts) with different stages of rheumatoid arthritis (RA). <h3>Methods</h3> Patients (n=80) with active RA and an inadequate response to synthetic DMARDs or biologics (adalimumab, rituximab, tocilizumab) were divided in two groups, patients with less than three years duration (ERA) and more than three years duration (LS RA) of RA. Pts with early RA and LS RA were 51% and 49%, respectively. Most of them were women, age 49±13 years, with a high disease activity (DAS28=5,28±1,1), RF-positive (75,7%) and ACPA-positive (75%). Infusions of abatacept (10 mg/kg) were provided three times every 2 weeks followed by every 4 weeks. Disease activity was assessed by DAS28. Results were assessed every 12 weeks according to EULAR criteria. <h3>Results</h3> Initially patients with early RA has DAS28 5,26±0,89, with long-standing RA - 5,3±1,3. ABA decrease activity of RA in both groups, after 3 months of therapy good and moderate response by EULAR criteria was achieved in 82.2% in the group of ERA and in 67.5% of patients with LS RA (p&lt;0.05). There was no significant difference in achieving good EULAR response between two groups after 3 months (26,47% - ERA; 25,7% - LS RA) and 6 months of therapy (31,9% - ERA; 35,2% - LS RA). However, the number of non-responders to the therapy in pts with LS RA was significantly higher both after 3 months and 6 months (32,35% and 25,3%) as compared to pts with ERA (17.6% and 17.02% respectively). There were registered 25 adverse events (AE) in 19 (23%) pts. The most frequent AE were upper respiratory tract infections - 8 pts. One pt has herpes zoster and one, abscess of the right thumb. <h3>Conclusions</h3> Abatacept has shown significant clinical benefit in patients who had an inadequate response to previous therapy. There was no significant difference in achieving good EULAR response between pts with early and LS RA. There were more patients with an inadequate response to ABA in the LS RA group. ABA was well tolerated, AE were registered only in 23% of patients. ABA is an effective drug with a good safety profile in the treatment of both LS and ERA. <h3>Disclosure of Interest</h3> None declared
Description and analysis of 12 years of surveillance for Creutzfeldt–Jakob disease in Denmark, 1997 to 2008
Authors: S Gubbels, S Bacci, H Laursen, H Høgenhaven, S Cowan, K Mølbak, M Christiansen
Journal: Eurosurveillance (2012)

Prospective surveillance of Creutzfeldt–Jakob disease (CJD) was initiated in Denmark in 1997, following the observation of variant CJD in the United Kingdom. Demographic, clinical and diagnostic information was collected for each patient with clinical suspicion of CJD. Here we describe the methods for surveillance and the observed outcomes between 1 January 1997 and 31 December 2008. A total of 83 patients were classified as sporadic CJD, 47 were definite diagnoses, 34 probable and two possible. This resulted in a mean incidence of 1.26 patients with probable and definite sporadic CJD per million inhabitants. Two sporadic CJD patients were found to have a genetic variant of unknown significance: Thr201Ser and Glu200Asp. One patient was diagnosed with Gerstmann-Sträussler-Scheinker syndrome. No patients were classified as having variant, iatrogenic or familial CJD. The Danish surveillance system, like those in other countries, has a multidisciplinary approach, which is labour-intensive and time-consuming but ensures the most complete set of information possible. With this approach we think that patients with variant CJD would have been detected had they occurred in Denmark. Certain aspects of CJD surveillance need further discussion at European level and beyond, in order to find a balance between efficiency of the systems and accuracy of surveillance data.
An easier option for endoscopic ultrasound-guided biliary drainage: cannulation using two antiparallel guidewires
Authors: Maria Ribeiro, Matheus Franco, Fauze Maluf-Filho
Journal: Endoscopy (2016)

A 35-year-old female patient receiving palliative chemotherapy for advanced pancreatic neuroendocrine tumor was referred to hospital with fever and obstructive jaundice.
Polymerase chain reaction monitoring for bcl-2 can be a dependable test under the right conditions.
Authors: F Cabanillas, M S Lee
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.3.795 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7884438 Polymerase chain reaction monitoring for bcl-2 can be a dependable test under the right conditions. F CabanillasxF CabanillasSearch for articles by this author , M S LeexM S LeeSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.3.795 PDF "Polymerase chain reaction monitoring for bcl-2 can be a dependable test under the right conditions.." Journal of Clinical Oncology, 13(3), pp. 795–796© 1995 by American Society of Clinical Oncology
Return to play post-Achilles tendon rupture: a systematic review and meta-analysis of rate and measures of return to play
Authors: Jennifer A Zellers, Michael R Carmont, Karin Grävare Silbernagel
Journal: British Journal of Sports Medicine (2016)

This systematic review and meta-analysis sought to identify return to play (RTP) rates following Achilles tendon rupture and evaluate what measures are used to determine RTP.A systematic review and meta-analysis were performed. Studies were assessed for risk of bias and grouped based on repeatability of their measure of RTP determination.PubMed, CINAHL, Web of Science and Scopus databases were searched to identify potentially relevant articles.Studies reporting RTP/sport/sport activity in acute, closed Achilles tendon rupture were included.108 studies encompassing 6506 patients were included for review. 85 studies included a measure for determining RTP. The rate of RTP in all studies was 80% (95% CI 75% to 85%). Studies with measures describing determination of RTP reported lower rates than studies without metrics described, with rates being significantly different between groups (p<0.001).80 per cent of patients returned to play following Achilles tendon rupture; however, the RTP rates are dependent on the quality of the method used to measure RTP. To further understand RTP after Achilles tendon rupture, a standardised, reliable and valid method is required.
A high affinity kidney targeting by chitobionic acid-conjugated polysorbitol gene transporter alleviates unilateral ureteral obstruction in rats
Authors: Mohammad Ariful Islam, Sanghwa Kim, Jannatul Firdous, Ah-Young Lee, Seong-Ho Hong, Min Kyeong Seo, Tae-Eun Park, Cheol-Heui Yun, Yun-Jaie Choi, Chanhee Chae, Chong-Su Cho, Myung-Haing Cho
Journal: Biomaterials (2016)
Case 6-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Oglesby Paul, Benjamin Castleman
Journal: New England Journal of Medicine (1970)

Presentation of Case*A sixty-seven-year-old man was admitted to the hospital because of severe dyspnea.Seven years previously he had been examined by a physician because of abdominal distress. The blood pressure was 200 systolic, 110 diastolic. An x-ray film of the chest showed a cardiothoracic ratio of 16:32, with prominence of the left ventricle. An electrocardiogram (Fig. 1) demonstrated a normal rhythm at a rate of 70; the P waves were low in the limb leads, with slight ST-segment sagging in Lead 1 and T-wave inversion in Lead 3; the pattern in the precordial leads was suggestive of left . . .
Cancer Tills the Premetastatic Field: Mechanistic Basis and Clinical Implications
Authors: Andrew R. Chin, Shizhen Emily Wang
Journal: Clinical Cancer Research (2016)

Abstract A growing body of work has shown that cancer metastasis is not a random spontaneous event; rather, it is the culmination of a cascade of priming steps through which a subpopulation of the tumor cells acquires invasive traits while readying a permissive environment, termed the "premetastatic niche," in which distant metastases can occur. Signals from the primary tumor mobilize and adapt immune cells as well as directly communicating with distant niche cells to induce a broad spectrum of adaptations in target organs, including the induction of angiogenesis, inflammation, extracellular matrix remodeling, and metabolic reprogramming. Together, these interactions facilitate the formation of a premetastatic niche composed of a variable mix of resident and recruited immune cells, endothelial cells, and stromal cells connected through a complex signaling network that we are only beginning to understand. Here, we summarize the latest findings on how cancer induces and guides the formation of this premetastatic niche as well as potential prognostic markers and therapeutic targets that may lead to a better understanding and effective treatment of metastatic disease. Clin Cancer Res; 22(15); 3725–33. ©2016 AACR.
Failure of urinary MHPG levels to predict treatment response in patients with unipolar depression
Authors: P G Janicak, J M Davis, C Chan, E Altman, D Hedeker
Journal: American Journal of Psychiatry (1986)

The authors studied 64 depressed patients who were receiving a vanillylmandelic acid (VMA)-free diet and underwent a washout period (mean, 24 days) before treatment. During the washout period, a mean of 2.5 multiple 24-hour urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) samples per patient were collected. Thirty-four patients were then treated with a "noradrenergic" antidepressant only (e.g., imipramine), and seven were treated with a "serotonergic" antidepressant only (e.g., amitriptyline). Twelve patients received combined drug treatment and 11 others spontaneously remitted. Response to treatment was rated on a clinical global evaluation scale from 1 (little or no response) to 7 (maximum response). No relationship was found between response to treatment, type of treatment, and the average pretreatment 24-hour urinary MHPG level. The authors thus failed to confirm the hypothesis that a low MHPG level predicts response to antidepressant treatment.
AB0948 Proinflammatory Cytokine and OX-LDL Levels in Fibromyalgia Patients
Authors: S. Özdolap, F. Canpolat Kutu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Although fibromyalgia (FM) is known a non-inflammatory condition, emerging data suggest that FM has an immunologic component. The levels of several inflammatory cytokines are abnormal in patients with FM and may play role in its pathogenesis. <h3>Objectives</h3> The aim of this study was to evaluate the proinflammatory cytokines including TNF-α, IL-1β, IL-8 and oxidized-LDL levels in serum of patients with FM. We also tried to determine the relationship among proinflammatory cytokines and oxidized-LDL, and disease severity. <h3>Methods</h3> Forty-three healthy women and forty-eight patients with FM, classified according to the ACR 2010 criteria were included in the study. The serum concentrations of TNF-α, IL-1β, IL-8 and oxidized-LDL were measured. Functional status of patients and disease severity were evaluated by Fibromyalgia Impact Questionairre (FIQ). Number of Tender Points (NTP) was determined. Widespread pain was evaluated with Visual Analog Scale (VAS). Widespread Pain Index (WPI) and Symptom Severity Scale (SSS) were calculated. <h3>Results</h3> Serum TNF-α, IL-1β, IL-8 and oxidized LDL were not statistically different between patient and healthy control groups (p values; p=0,144; p=0,284; p=0,186; p=0,379; respectively). No statistically significant difference was found between FIQ scores and parameters including serum TNF-α, IL-1β, IL-8, oxidized LDL (p values; p=0,066; p=0,885; p=0,061; p=0,453; respectively). Relationship among NTP and serum proinflammatory cytokines (TNF-α, IL-1β, IL-8) and oxidized-LDL levels were not statistically significant (p values; p=0,502; p=0,285; p=0,261; p=0,600; respectively). VAS did not have statistically significant relationship with serum IL-1β and oxidized LDL (p values; p=0,243; p=0,154; respectively); but relationship between serum IL-8 ve TNF-α was statistically significant (p values; p=0,043; p=0,021; respectively). In addition the SSS had significant relationship with serum oxidized LDL in patient group (p=0,006). <h3>Conclusions</h3> These findings suggest that pain in fibromyalgia can be related serum TNF-α, IL-8 and Ox-LDL, and TNF-α, IL-8 and Ox-LDL can play a role in etiopathogenesis of fibromyalgia. <h3>References</h3> Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Giuliano T, De Feo F, Ciapparelli A, Dell9Osso L, Bombardieri S: Cytokines patterns in fibromyalgia and their correlations with clinical manifestations. Clin Exp Rheumatol 2007;25:225-230. Xiao Y, Haynes W, Michalek JE, Russell J. Elevated serum high-sensitivity C-reactive protein levels in fibromyalgia syndrome patients corralate with body mass index, interleukin-6, interleukin-8, erythrocyte sedimantation rate. Rheumatol International 2013;33:1259-1264. <h3>Disclosure of Interest</h3> None declared
The Inheritance of Susceptibility to Tumors Induced in Mice. III. Tumors induced with Methylcholanthrene in the Backcross of C3H and JK Mice<xref ref-type="fn" rid="fn1"><sup>2</sup></xref><xref ref-type="fn" rid="fn2"><sup>3</sup></xref>
Authors: Walter J. Burdette, Ph. D., M. D.
Journal: JNCI Journal of the National Cancer Institute (1948)

Journal Article The Inheritance of Susceptibility to Tumors Induced in Mice. III. Tumors induced with Methylcholanthrene in the Backcross of C3H and JK Mice Get access Walter J. Burdette, Ph. D., M. D. Walter J. Burdette, Ph. D., M. D. Department of Surgery, Louisiana State University School of Medicine, New Orleans Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 2, October 1948, Pages 105–110, https://doi.org/10.1093/jnci/9.2.105 Published: 01 October 1948 Article history Received: 21 April 1948 Published: 01 October 1948
The dexamethasone suppression test for major depression among opiate addicts
Authors: C A Dackis, A L Pottash, M S Gold, W Annitto
Journal: American Journal of Psychiatry (1984)

The authors gave the dexamethasone suppression test (DST) to 42 opiate addicts 2 weeks after detoxification. The DST provided a sensitivity of 80% and a specificity of 93% for major depression diagnosed according to the Research Diagnostic Criteria.
Catecholase and Catecholase-Inhibitor Activity of Human Blood Sera
Authors: Bernard Shacter, Ph.D., Michael B. Shimkin, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Catecholase and Catecholase-Inhibitor Activity of Human Blood Sera Bernard Shacter, Ph.D., Bernard Shacter, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael B. Shimkin, M. D. Michael B. Shimkin, M. D. Laboratory of Experimental Oncology, National Cancer Institute, National Institutes of Health, Public Health Service, and the University of California Medical School, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 637–645, https://doi.org/10.1093/jnci/10.3.637 Published: 01 December 1949 Article history Received: 29 August 1949 Published: 01 December 1949
Neutrophil-Activating Peptide-1/Interleukin-8 Detection in Human Urine during Acute Bladder Inflammation Caused by Transurethral Resection of Superficial Cancer and Bacillus Calmette-Guérin Administration
Authors: M Bettex-Galland, U E Studer, A Walz, B Dewald, M Baggiolini
Journal: European Urology (1991)