tbuckley/cabot-search huggingface dataset:
THU0182 Dyslipoproteinemia and its relation with the activity of the disease and its treatment in a large spanish multicentric lupus cohort:
Authors: J. Pego-Reigosa, I. Rúa, C. Mouriño, M. Galindo, F. Lόpez-Longo, J. Calvo, M. García-Yébenes, E. Tomero, E. Uriarte, C. Fito, A. Sánchez, A. Olivé, M. Freire, A. F-Nebro
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Abnormalities in the lipid profile contribute to the increased risk of early atherosclerosis in patients with SLE <h3>Objectives</h3> To study the dyslipoproteinemia in SLE and the influence of the disease activity and treatments on it. <h3>Patients</h3> SLE patients from the RELESSER Registry with an active follow up in a Rheumatology Department. <h3>Variables</h3> a) lipid profile: total, LDL/HDL cholesterol, triglycerides and atherogenic index (total/HDL cholesterol), b) SLE activity: SELENA-SLEDAI score, C3, C4 and anti-dsDNA antibodies and c) ongoing treatments. Dyslipoproteinemia is defined as the presence of at least one of the following criteria: total cholesterol ≥240mg/dl, triglycerides ≥180mg/dl or statins use. <b>Methods</b>. Retrospective study of the data collected at the moment of the last evaluation of the patient. We calculate the prevalence of dyslipoproteinemia and the correlations between lipid profile and the SLE activity and treatments. <h3>Results</h3> 583 patients were included (88.3% females, mean age: 45 years, SLE duration: median 111 months). Table 1 shows the results of the analysis of lipid profile. The median of the SLEDAI score was 2 (IR: 0-4). 39.4% of the patients had a SLEDAI score =0. The SLE activity was mild (SLEDAI =1-4 points), moderate (5-9 points) and severe (≥10 points) in 43.4, 13.2 and 3.9% of the patients, respectively. Total cholesterol levels were significantly higher in the subgroup of patients with severe activity (p=0.009). The LDL cholesterol and the atherogenic index also were higher in that subgroup (p = n.s.). We did not find significant differences in the values of the lipid profile in the subgroup of patients with hypocomplementemia or positive anti-dsDNA antibodies. The percentage of patients on statin therapy was significantly higher in the group of patients with severe lupus activity (p=0.05). The patients on current treatment with corticosteroids or with 2 immunosupressors had a higher prevalence of dyslipoproteinemia than those without corticosteroids or with ≤1 immunosupresor (p=0.009 and p=0.04, respectively). Patients on antimalarial therapy had lower triglycerides levels and lower prevalence of dysliproteinemia than those without that treatment (p close to 0.05). <h3>Conclusions</h3> One third of the Spanish SLE patients had dyslipoproteinemia. Total cholesterol levels and statin requirement are significantly higher in the patients with higher disease activity. The use of corticosteroids and a more aggressive immunosupressive regimen are associated with higher prevalence of dyslipoproteinemia. <h3>Disclosure of Interest</h3> None Declared
GDF15 AND ST2 IDENTIFY PATIENTS WITH AORTIC STENOSIS AND SEVERE LEFT VENTRICULAR HYPERTROPHY AT INCREASED RISK FOR MORTALITY AFTER AORTIC VALVE REPLACEMENT
Authors: Marc Sintek, Nishath Quader, Hersh Maniar, Alan Zajarias, Eric Novak, Anna Vatterott, Cassie Lawler, Alejandro Aquino, John Lasala, Jared Breyley, Jennifer Lawton, Marc Moon, Spencer Melby, Ralph Damiano, Brian Lindman
Journal: Journal of the American College of Cardiology (2016)
Prevalence of antibodies against influenza A and B viruses in children in Germany, 2008 to 2010
Authors: A Sauerbrei, T Langenhan, A Brandstädt, R Schmidt-Ott, A Krumbholz, H Girschick, H Huppertz, P Kaiser, J Liese, A Streng, T Niehues, J Peters, A Sauerbrey, H Schroten, T Tenenbaum, S Wirth, P Wutzler
Journal: Eurosurveillance (2014)

Binary file ES_Abstracts_Final_ECDC.txt matches
A4.08 Predicting senescence-related loss of MSC osteogenic capacity irrespective of donor age
Authors: SM Churchman, SA Boxall, D McGonagle, EA Jones
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objectives</h3> Multipotential stromal cells (MSCs) have considerable regenerative capabilities and their premature senescence <i>in vivo</i>&nbsp;may be responsible for altered bone phenotypes in age-related skeletal diseases including osteoporosis and osteoarthritis. Following minimal culture expansion, MSCs lose their native molecular phenotype (Churchman, Arthritis Rheum, 2012). However it is not known whether this continues to change as MSC reach senescence and whether any molecular markers could be predictive of senescence-related loss of MSC osteogenic capacity. <h3>Materials and methods</h3> Bone marrow (BM, n = 7) was obtained from a deliberately diverse age range (2–72 years) of healthy donors. MSCs were selected for by plastic adherence and culture expanded up to senescence. Throughout the expansion period samples were taken for RNA and gDNA extraction as well as osteogenic differentiation. Gene expression profiles were studied by 96-gene Taqman low density array, whilst epigenetic senescence signature analysis was performed on the gDNA. <h3>Results</h3> Cultures from older donors reached senescence considerably earlier compared to younger donors (r&nbsp;=&nbsp;-0.703). For all donors combined, MSC osteogenic capacity correlated better with population doublings (PDs) before senescence than with accrued PDs. Regardless of the donor age, the majority (59/78) of the genes were unchanged throughout the expansion period, with exceptions including <i>TNFRSF11B</i>/osteoprotegrin, <i>CDH11</i>/osteogenic cadherin, <i>COL1A1</i>/collagen type I and <i>SPARC</i>/osteonectin (all higher by senescence compared to early passage), and NANOG (lower in senescent cultures). The methylation status of cells correlated equally well with both PD and PD before senescence. Following osteogenic differentiation many genes were &nbsp;upregulated up to 200-fold and <i>TNFRSF11B</i> was less upregulated closer to senescence. <h3>Conclusion</h3> Compared to methylation markers, the expression of<i> TNFRSF11B</i>/osteoprotegrin may be a better predictor of BM MSC senescence&nbsp;and related loss of&nbsp;osteogenic capability independent of donor age.
ARE THERE DIFFERENCES IN IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR COUNSELING RATES AMONG ELIGIBLE PATIENTS HOSPITALIZED FOR HEART FAILURE? NATIONAL RESULTS FROM THE AMERICAN HEART ASSOCIATION’S GET WITH THE GUIDELINES- HEART FAILURE PROGRAM
Authors: Paul L. Hess, Adrian F. Hernandez, Deepak L. Bhatt, Anne S. Hellkamp, Clyde W. Yancy, Lee H. Schwamm, Eric D. Peterson, Philip J. Schulte, Gregg C. Fonarow, Sana M. Al-Khatib
Journal: Journal of the American College of Cardiology (2015)
Rectal Use of Ergotamine Tartrate and Caffeine Alkaloid for the Relief of Migraine
Authors: John R. Graham
Journal: New England Journal of Medicine (1954)

IN 1894 Thomson1 recommended the treatment of "periodic neuralgia of the head" by a rectal infusion of tincture of ergot. Despite the reported success of this method the derivatives of ergot were not widely employed in the treatment of headache of the migraine type until 1928, when Tzanck2 used ergotamine tartrate for migraine in Europe; Lennox3 introduced it into this country in 1934, recommending both oral and parenteral administration. The rectal route seems to have been neglected until the past three years, when several observers4 , 5 reported the efficacy of ergotamine tartrate and caffeine alkaloid for migraine when used in the . . .
Sarcomas Induced by Injection of Simian Virus 40 Into Neonatal CFW Mice&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: B J Hargis, S Malkiel
Journal: JNCI Journal of the National Cancer Institute (1979)

Sarcomas were induced in CFW mice by the iv inoculation of simian virus 40 (SV40) in neonatal animals. Infection with murine malaria parasites, Plasmodium berghei yoelli, decreased the latency and increased the incidence and invasiveness of the tumors. All mice given both SV40 and P. berghei yoelli had sarcomas of the liver and spleen at 9 months of age. At 11 months of age, 70% of the SV40-inoculated mice had sarcomas of the liver indistinguishable from those in the group given both pathogens. Only 1 lung metastasis was seen in the SV40-treated group. The sarcomas contained SV40 T-antigen as revealed by the indirect immunofluorescence technique. Among adult CFW mice given iv injections of SV40, only 2 tumors were found at 11 or 12 months after virus inoculation. Both tumors were in the lungs; 1 was an adenoma and 1 was a papillary adenocarcinoma. Neither gave a positive reaction with the immunofluorescence test.
Abstract LB-144: I-kappa-B kinase (IKK)ε expression in pancreatic ductal adenocarcinoma
Authors: Jianping Guo, Anna Cheng, Evita B. Henderson-Jackson, Donghwa Kim, Mokenge Malafa, Domenico Coppola
Journal: Cancer Research (2011)

Abstract I-kappa-B-kinase (IKKε) is a serine/threonine protein kinase that belongs to the IKK kinase family. Recent studies have shown that IKKε functions as a breast and ovarian cancer oncogene. Here we demonstrate frequent overexpression of IKKε in pancreatic ductal adenocarcinoma (PDA). We immunohistochemically evaluated 78 PDA using the avidin-biotin-peroxidase method and the anti-IKKε, rabbit polyclonal antibody. Elevated IKKε reactivity (IHC score 4–9) was observed in 64.1 % (50/78) PDAs, but in 0% (0/113) of non neoplastic pancreatic ductal epithelium (NMP) (p &amp;lt; 0.001). Kaplan-Meier analysis of overall survival (OS) revealed that patients with high IKKε-IHC scores (4–9) had a significantly shorter survival than that of patients with low IKKε -IHC scores (0–3) (Log-rang test p = 0.023), independent of either tumor stage or grade. These data indicate that deregulation of IKKε is a common event in PDA and might play an important role in the pathogenesis of this deadly disease. In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-144. doi:10.1158/1538-7445.AM2011-LB-144
LA EFICACIA DE LA ULTRASONOGRAFÍA ENDOSCÓPICA EN LA CARACTERIZACIÓN DE LESIONES TUMORALES EN LA PANCREATITIS CRÓNICA
Authors: L Pérez Carazo, B Merino Rodríguez, C González Asanza, O Nogales Rincón, A Ochoa, F Díaz Fontenla, A Ahumada, E Cos, P Menchén Fernández Pacheco
Journal: Endoscopy (2012)

Introducción: La ultrasonografía endoscópica (USE) es el método de referencia para el diagnóstico y estadificación locoregional de los tumores pancreáticos. El principal problema se encuentra en las masas inflamatorias de los pacientes con pancreatitis crónica. Objetivos: Determinar la influencia de la USE en la detección de la pancreatitis crónica e identificación de masas pancreáticas sospechosas por otras pruebas de imagen. Material y método: Prospectivamente entre enero de 2008 y junio de2012 se han realizado 132 estudios consecutivos pancreáticos con sospecha de una masa pancreática mediante tomografía axial computarizada, resonancia magnética, ecografía abdominal o CPRE. Todos los pacientes fueron sometidos USE, y en caso de visualizarse una masa se realizó punción de la misma. Los pacientes fueron sometidos a exploración quirúrgica o seguimiento clínico y radiológico durante 6 meses para confirmar los resultados de la USE. Resultados: La distribución por género fue 71% varones y 29% mujeres. La edad media fue de 66.4 años. No hubo complicaciones relacionadas con el procedimiento. La pancreatitis crónica se sospechó en 71 individuos por métodos clínicos o radiológicos. Usando Criterios ultrasonográficos estándar la pancreatitis crónica se confirmó 53 en (74.6%) de los pacientes. En 30 pacientes con pancreatitis crónica detectados por EUS, el motivo de petición fue sospecha de masa pancreática. En 21 (70%) pacientes se confirmó la existencia de masa pancreática (el resto fueron falsos positivos de las otras pruebas de imagen). En 5 de los pacientes con masas pancreática y pancreatitis crónica (23.8%) se confirmó la existencia de adenocarcinoma y el resto de masas fueron de naturaleza inflamatoria. La USE-aspiración con aguja fina de lesiones sólidas, en estos pacientes, tiene una sensibilidad y especificidad del 87,9% y 100%, respectivamente. Conclusiones: La ecoendoscopia es superior a otras modalidades radiológicas en la determinación de la pancreatitis crónica y la detección de lesiones tumorales.
Abstract LB-70: Breaking the Silence
Authors: Shaundra Hall
Journal: Cancer Research (2011)

Abstract The National Cervical Cancer Coalition (NCCC) is a grassroots organization that exists solely to educate and support patients, caregivers, family members, and communities about cervical cancer and other HPV-related diseases. NCCC is responsible for the development of the nation's first hotline devoted to helping women and family members resolve issues they have related to cervical cancer and HPV. The NCCC also developed the Cervical Cancer/HPV Quilts Project that travels the country to help put a personal face on the disease. The NCCC began the nationally-recognized FREE Pap Test Day held on the second Friday of January to enable disadvantaged women who have not received a Pap test in the past three years. The NCCC runs an award winning cervical cancer website and is currently developing a national network of local state affiliates. The NCCC cosponsored two fundraising conferences on cervical cancer issues in Malawi, Africa, and has held many prevention education fundraisers over the years as well. The coalition is developing a national grassroots effort in all 50 states. Through the efforts of our coalition members, we are addressing issues of cervical cancer/HPV prevention with education about vaccination and regular Pap and HPV testing. The organization always works to reduce the stigma associated with HPV infection and cervical cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-70. doi:10.1158/1538-7445.AM2011-LB-70
FRI0355 Evaluation of asymptomatic venous disease by venous doppler ultrasonography in patients with behcet’s disease without overt thrombosis
Authors: F. Alibaz-Oner, E. Karatay, I. N. Akpınar, T. Ergun, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> One of the major causes of mortality and morbidity in Behcet's disease (BD), especially in young males of Mediterranean region, is vascular involvement. Alimited data suggests a high prevelance of venous insufficiency (VI) and some cases of asymptomatic thrombosis in patients with BD. In this study, we aimed to investigate asymptomatic venous disease by venous doppler ultrasonography (US) prospectively in patients with BD without known vascular disease. <h3>Methods</h3> The study included 93 patients with BD (M/F: 45/48, age: 36.4±10 years), 97 patients with ankylosing spondylitis (AS)(M/F: 50/47, age: 37.5±9.5 years) and 43 healthy control subjects (M/F: 25/18, age: 34.7±4.5 years). Vessels of both upper and lower extremities were examined while the subjects were in supine position by venous doppler US. CEAP severity score was used to evaluate the severity of the venous insuficiency. <h3>Results</h3> Upper extremity veins were totally normal in all patients and controls. We also did not detect any "silent thrombosis" in study groups. Venous insufficiency findings in lower extremity were detected in 32.2% (n=30) in the BD group, 28.8% (n=28) in AS group and 9.3% (n=4) in the healthy control group. Both BD and AS patients had significantly higher VI rates than healthy controls (p=0.007 and 0.015). The rate of VI was similar between patients with BD and AS (p=0.64). Similarly, CEAP severity score in BD (0.34 (0-3)) was significantly higher than controls (0)(p=0.008), but similar to AS (0.18 (0-39)(p=0.18). No correlations were present between C-reactive protein elevation (&gt;5 mg/L) and VI in patients with both BD (p=0.546) and AS (p=0.754). <h3>Conclusions</h3> Ahigh prevelance of venous insufficiency was present in both BD and AS patients without asymptomatic thrombosis. Presence of VI also in AS, a disease without a major tendency to venous thrombosis, suggests that chronic inflammation might cause a mild insufficiency detected only by Power US in venous vessels. Long-term consequences of this finding requires further follow-up studies. <b>Disclosure of Interest</b>: None Declared
Abstract 485: Hypoxia increases the expression of stem-cell markers and promotes cell invasion in prostate cancer cells
Authors: Kyungmi Bae, Yao Dai, Johannes Vieweg, Dietmar Siemann
Journal: Cancer Research (2011)

Abstract Oxygen is an essential regulator of cellular metabolism, survival, and proliferation. Cellular responses to oxygen levels are monitored, in part, by the transcriptional activity of the hypoxia inducible factors (HIFs). The existence of hypoxic microenvironment is a common occurrence in many solid tumors including prostate. Previous studies from our laboratories have shown that in human prostate cancer models, cancer stem cells expressing the embryonic stem cell markers SOX2 and OCT3/4 were highly invasive and, importantly, were capable of altering their E-cadherin expression during the process of invasion. In contrast, non-tumorigenic cells which minimally express SOX2 or OCT3/4 were found to be poorly invasive. Furthermore, targeted knockdown of SOX2 or OCT3/4 markedly suppressed the invasion of prostate cancer cells, suggesting an indispensible role of these two stem cell markers in invasiveness. In the present study, we examined the impact of oxygen deprivation on cell invasiveness and stemness in both stem cell enriched and non-stem cell populations in PC3 and DU145 prostate cancer cells. Moreover, the impact of Notch signaling, which has been shown as a critical regulator of prostate cancer development, progression and metastasis, was examined. When cells were exposed to 1% oxygen for 24 h, the invasive capacity of both the stem- and non-stem cell subpopulations increased. Interestingly the non-stem cell subpopulation showed the most striking increase (&amp;gt; 10-fold) in invasion under hypoxic conditions. The expression of several important stem cell factors, including OCT3/4, SOX2, Nanog and c-Myc, also was upregulated under hypoxia in both subpopulations. In addition, the expression of Notch1, Notch2 and their target genes Hey1, Hey2 and HeyL were increased in both subpopulations that had experienced oxygen deprivation (1% O2, 24 h). These findings suggest that although cancer stem cells per se exhibit significantly greater invasive capacity, aberrant microenvironmental conditions such as hypoxia may dramatically enhance the ability of non-stem cells to invade. Consequently, both the stem and non-stem cell subpopulations of tumors may be potential targets for the development of suitable therapeutic interventions designed to inhibit prostate cancer cell invasion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 485. doi:10.1158/1538-7445.AM2011-485
AB1173-HPR Relationship between Patient-Reported and Objective Measurements of Function in Patients with Rheumatoid Arthritis: A Pilot Study
Authors: S.M. Günay, Z. Tuna, D. Oskay
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic, inflammatory, and systemic disease often results in impairments in upper extremities and therefore, limitations in activities of daily living, Cinically, it is observed that patients9 complaints about their disabilities do not always match with their actual physical performance. <h3>Objectives</h3> The aim of this pilot study is to investigate the relationship between patient self-reported functional levels of hands and objective functional performance in RA patients. <h3>Methods</h3> Twenty-six patients (51±13 years) with RA diagnosis participated in the study. Hand-grip and pinch (lateral, bipod, tripod) strengths were measured and Nine-Hole Peg Test and Jebsen Hand Function Test (JHFT) were performed for objective functional performance. Michigan Hand Outcome Questionnaire (MHOQ)and Duruöz Hand Index were completed by patients. <h3>Results</h3> Grip and all three pinch strength results were significantly correlated with Duruöz Hand Index scores (p&lt;0,05). JHFT results except the sentence writing were also correlated with the Duruöz scores (p&lt;0,05). MHOQ scores were related to the grip strength, JHFT and Nine-Hole Peg Test results (p&lt;0,05). <h3>Conclusions</h3> Our results showed that self-reported outcome scales may be used for determining functional level of hand in patients with RA in rheumatology practice.Objective quantitative functional tests are the best methods in evaluating functional level of hand, however it requires valid and reliable equipments with accurate calibration. Therefore, in case of inavailablity of objective assessment tools, patient-reported scales may be used instead. <h3>References</h3> Shin SY, Katz P, Julian L.Relationship Between Perceived Cognitive Dysfunction And Objective Neuropsychological Performance İn Persons With Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2013 Mar;65(3):481-6 Eurenius E, Stenström CH.Physical Activity, Physical Fitness, And General Health Perception Among İndividuals With Rheumatoid Arthritis. Arthritis Rheum. 2005 Feb 15;53(1):48-55 Tuominen R, Tuominen S, Suominen C, Möttönen T, Azbel M, Hemmilä J.Perceived Functional Disabilities Among Rheumatoid Arthritis Patients. Rheumatol Int. 2010 Mar;30(5):643-9. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2333