tbuckley/cabot-search huggingface dataset:
Correlation between the results of three physical fitness tests (endurance, strength, speed) and the output measured during a bicycle ergometer test in a cohort of military servicemen
Authors: Stefan Sammito, Nils Gundlach, Irina Böckelmann
Journal: Military Medical Research (2016)

Physical fitness tests are widely used to assess endurance, sprint ability, coordination and/or strength. The objective of the present study was to analyze the degree to which the results of the Bundeswehr Basis Fitness Test (BFT)--a physical fitness test comprising a sprint test (11 × 10-m shuttle test), a flexed-arm hang test and a 1000-m run--are consistent with the output measured during a bicycle ergometer test. The number of false-positive and false-negative results with regard to the assessment of physical fitness were also examined.As part of a retrospective study, health assessments from 323 reenlistment examinations were evaluated regarding the output measured during a bicycle ergometer test and compared with the BFT results of the candidates.Overall, a good correlation was shown between the bicycle ergometer test results and the results achieved in the BFT disciplines. All three disciplines of the BFT showed a highly significant correlation with the relative output achieved during the bicycle ergometer test (P < 0.001), and also, the overall BFT score was highly significantly correlated (P < 0.001). The overall rate of false-positive and false-negative results was 4.0 %.The BFT results measured in the three physical fitness test items were highly correlated with the output measured during the bicycle ergometer tests. The rate of false-positive and false-negative results was low. The test items thus represent an appropriate measurement instrument because the test items require few equipment and less time. Additionally, a large number of subjects can be assessed. We suggest that it would be more useful to assess the physical fitness of this special group exclusively on the basis of the BFT instead of using the bicycle ergometer test.
Spontaneous Perforation of the Umbilicus in Laënnec's Cirrhosis with Massive Ascites
Authors: Frank B. Flood
Journal: New England Journal of Medicine (1961)

SPONTANEOUS perforation of the umbilicus in Laënnec's cirrhosis with massive ascites is an unusual, serious and frequently fatal complication of this disease. It requires emergency medical and surgical care.In a period of two and a half years from January, 1958, to July, 1960, 5 of 101 (5 per cent) patients with portal cirrhosis and ascites were admitted to St. Vincent's Hospital because of perforation, and all 5 died.The literature records 3 previous cases1 2 3 of spontaneous paracentesis. Two of the 3 patients survived the episode; 1 died with peritonitis, hyperkalemia and azotemia.2 Case ReportsCase 1. R.L. (S.V.H. 032671), . . .
Abstract 2838: Sequential Changes of Left Ventricular Systolic and Diastolic Synchronicity in Acute ST-Elevation Myocardial Infarction after Primary Coronary Intervention
Authors: Seong-Mi Park, Yong-Hyun Kim, Soon-Jun Hong, Do-Sun Lim, Wan-Joo Shim
Journal: Circulation (2008)

The aims of this study were to assess the sequential changes of left ventricular (LV) systolic and diastolic synchronicity in patients with acute myocardial infarction (AMI) and to assess their relation with LV recovery and remodeling. Forty-patients with acute ST-elevation MI were examined within 2days, 6weeks and 6months after primary coronary intervention. Fifteen-age matched subjects were enrolled for normal control. The time from the onset of QRS complex to peak systolic velocity (Ts) and to peak early diastolic velocity (Te) were measured on color-coded tissue Doppler imaging. To assess LV synchronicity, SDs of Ts (Ts-SD) and Te (Te-SD) of all 12 segments were calculated (within 2days, at 6weeks and 6months; SD1, SD2 and SD3, respectively). LV recovery was defined as the improvement of wall motion at least more than two segments at 6 weeks. In all AMI patients, the wall motion score index was 1.72±0.27 and LV ejection fraction was 45.9±9.9%. The Ts-SD1 was higher in AMI patients than in controls (45.4±13.5 vs 29.4±13.3ms, p&lt;0.05), but Te-SD1 was not different (18.7±6.9 vs 16.2±10.0). Twenty-two patients (group1) showed a recovery and 18 patients (group2) showed no recovery. The Ts-SD1 was smaller in group1 than in group2 (43.4±12.6 vs 47.9±11.7 ms, p&lt;0.05). In group1, Ts-SD were much decreased as follow up (Ts-SD2, 3; 36.6±14.0 and 31.1±9.5, respectively, p&lt;0.05). In contrast, in group2, Ts-SD was not significantly changed (Ts-SD2,3; 46.7±13.2 and 43.7±8.8, respectively) but Te-SD was increased as follow up (Te-SD1,2,3; 17.8±5.5, 20.4±4.3 and 25.0±3.8, respectively, p&lt;0.05). The LV end-diastolic and systolic volume were increased and the deceleration time of early diastolic mitral inflow velocity was shortened in group2 (p&lt;0.05). This clinical study shows: 1) in acute phase, the regional wall motion abnormalities of AMI had an impact on LV systolic synchronicity; 2) the AMI patients with LV recovery showed better LV systolic synchronicity; 3) the LV systolic synchronicity became better as regional wall motion was improved; and 4) in chronic phase, the LV diastolic synchronicity became worse in AMI patients with no recovery, which might be related to LV remodeling and worsening of LV diastolic function.
Angiographic Follow-up after Placement of a Self-Expanding Coronary-Artery Stent
Authors: Patrick W. Serruys, Bradley H. Strauss, Kevin J. Beatt, Michel E. Bertrand, Jacques Puel, Anthony F. Rickards, Bernhard Meier, Jean-Jacques Goy, Pierre Vogt, Lukas Kappenberger, Ulrich Sigwart
Journal: New England Journal of Medicine (1991)

The placement of stents in coronary arteries after coronary angioplasty has been investigated as a way of treating abrupt coronary-artery occlusion related to the angioplasty and of reducing the late intimal hyperplasia responsible for gradual re-Stenosis of the dilated lesion.
Case 6-1963
Journal: New England Journal of Medicine (1963)

Presentation of Case A forty-two-year-old man was referred to the hospital for evaluation of weakness and recurrent pulmonary infections. The patient had had severe pneumonia eight times during the previous twenty-eight years, including three episodes necessitating hospital admission during the year before entry. Each infection was characterized by the sudden onset of fever with the temperature as high as 103°F., shaking chills, nausea, anorexia and subcostal chest pain. A persistent chronic cough had been present for fifteen years, yielding approximately a half cup of yellow-green sputum daily with occasional blood streaking. Studies for acid-fast organisms had been negative. He had . . .
Chronic Idiopathic Neutropenia
Authors: Eugene A. Browne, Aaron J. Marcus
Journal: New England Journal of Medicine (1960)

THE absence of granulocytes from the peripheral blood is characterized by a clinical picture of overwhelming infection, involving especially the skin and mucous membranes.1 Many cases are acute, and the causative agent can be demonstrated. The chronic form is more difficult to classify, and several types have been described.Cyclic neutropenia,2 for example, is characterized by regularly recurring periods of illness, frequently at intervals of three to four weeks, sometimes during the menses. In primary splenic neutropenia3 , 4 the bone marrow is normal or hyperplastic, and splenectomy provides a cure. Chronic hypoplastic neutropenia5 does not respond to splenectomy, and the bone . . .
Rhabdomyolysis, When Observed With High-Dose Interferon-Alfa (HDI) Therapy, Does Not Always Exclude Resumption of HDI
Authors: G. J. van Londen, B. Mascarenhas, J. M. Kirkwood
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.17.3794 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11533109 Rhabdomyolysis, When Observed With High-Dose Interferon-Alfa (HDI) Therapy, Does Not Always Exclude Resumption of HDI G. J. van LondenxG. J. van LondenSearch for articles by this author , B. MascarenhasxB. MascarenhasSearch for articles by this author , J. M. KirkwoodxJ. M. KirkwoodSearch for articles by this author Show More Melanoma Center, University of Pittsburgh Cancer Institute, Pittsburgh, PA https://doi.org/10.1200/JCO.2001.19.17.3794 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Altered Karyotypes of Transplantable “Diploid” Tumors2
Authors: Sandra R. Wolman, Allan A. Horland, Frederick F. Becker
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Altered Karyotypes of Transplantable “Diploid” Tumors Get access Sandra R. Wolman, Sandra R. Wolman Search for other works by this author on: Oxford Academic PubMed Google Scholar Allan A. Horland, Allan A. Horland United States Public Health Service Fellow in Pathology Search for other works by this author on: Oxford Academic PubMed Google Scholar Frederick F. Becker Frederick F. Becker Department of Pathology, New York University School of Medicine, 550 First Ave., New York, N.Y. 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 6, December 1973, Pages 1909–1914, https://doi.org/10.1093/jnci/51.6.1909 Published: 01 December 1973 Article history Received: 29 May 1973 Accepted: 24 August 1973 Published: 01 December 1973
Latent Varicella–Zoster Viral DNA in Human Trigeminal and Thoracic Ganglia
Authors: Ravi Mahalingam, Mary Wellish, William Wolf, Aud N. Dueland, Randall Cohrs, Abbas Vafai, Donald Gilden
Journal: New England Journal of Medicine (1990)

Some human herpesviruses become latent in dorsal-root ganglia. Primary infection with the Varicella Zoster virus causes chickenpox, followed by latency, and subsequent reactivation leading to shingles (zoster), but the frequency and distribution of latent virus have not been established.
Lung Stereotactic Body Radiotherapy for Early-Stage NSCLC in Patients With Prior Pneumonectomy: A Case Report
Authors: Daniel R. Simpson, Parag Sanghvi, Ajay P. Sandhu
Journal: Journal of the National Comprehensive Cancer Network (2014)

Stereotactic body radiotherapy (SBRT) has become the standard of care for patients with medically inoperable early-stage non-small cell lung cancer (NSCLC). A paucity of published data exists regarding the safety of SBRT use in patients with prior pneumonectomy. This report describes 2 patients with NSCLC and prior pneumonectomy who were treated with lung SBRT and experienced a favorable treatment response with no major adverse treatment effects. The data presented herein are promising and provide early evidence that lung SBRT is a safe and feasible option in this subset of patients.
P56 Cross-sectional study of prevalence of sensitisation to mouse allergens in laboratory animal workers: the SPIRAL (Safe Practice In Reducing Allergy in Laboratories) study
Authors: JR Feary, B Fitzgerald, Z Lightfoot, W Banya, M Jones, P Cullinan
Journal: Thorax (2015)

<h3>Introduction</h3> At least 12000 people work with laboratory animals in the UK. Approximately 15% of exposed employees develop specific IgE sensitisation and 10% clinical symptoms of occupational rhinitis and asthma due to laboratory animal allergy (LAA). Individually ventilated cages (IVCs) are increasingly replacing conventional open cages (primarily for mice welfare); whilst this can be associated with lower levels of ambient aeroallergen levels no corresponding reduction in incidence of LAA is apparent. The SPIRAL (Safe Practice In Reducing Allergy in Laboratories) study is a large multi-centred study designed to increase understanding of the complex association between workplace exposure to mouse allergens and development of sensitisation, and to evaluate the risk of working with mice today. <h3>Methods</h3> A cross-sectional study of animal workers at UK medical research institutions is underway. Primary outcome is a comparison of prevalence of sensitisation to mouse proteins in those working in IVC only and those working in mixed facilities (open cages +/- IVCs). Participants complete a detailed online questionnaire including questions about work tasks and practices. Skin-prick tests to common aeroallergens and various animal proteins are performed and blood samples analysed for serum specific IgE to Mus m 1 (mouse urinary protein) and mouse epithelium. Aeroallergen sampling for particulate matter and Mus m 1 is undertaken concurrently to provide objective exposure measurements (results presented elsewhere). <h3>Results</h3> 507 participants have been recruited to date. Analyses were restricted to those with less than 5 years exposure to mice (n = 212); of these, 10 (5%) participants were sensitised to mouse proteins. Prevalence of sensitisation was 3.5% in IVC only facilities and 6.3% in open cage/mixed facilities. Although numbers are small, a history of atopy to common aeroallergens and the site at which people worked appears to be associated with risk of sensitisation. Reporting of symptoms of laboratory animal allergy was as anticipated. (Table 1). <h3>Conclusion</h3> The results from the SPIRAL study will be used to develop an evidence-based “Code of best working practices” for facilities using IVC systems, nationally and further afield, with the overall goal of significantly reducing the incidence of LAA.
Genetic Linkage of the Marfan Syndrome, Ectopia Lentis, and Congenital Contractural Arachnodactyly to the Fibrillin Genes on Chromosomes 15 and 5
Authors: P Tsipouras, R Del Mastro, M Sarfarazi, B Lee, E Vitale, A H Child, M Godfrey, R B Devereux, D Hewett, B Steinmann
Journal: New England Journal of Medicine (1992)

The large glycoprotein fibrillin is a structural component of elastin-containing microfibrils found in many tissues. The Marfan syndrome has been linked to the fibrillin gene on chromosome 15, but congenital contractural arachnodactyly, which shares some of the physical features of the syndrome, has been linked to the fibrillin gene on chromosome 5.
Characteristics of the Newly Derived Human Chondrosarcoma Cell Line OSHU-1: Observations on Osteoinduction&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: H Hirano, M R Urist
Journal: JNCI Journal of the National Cancer Institute (1980)

A cell line designated OSHU-1 was produced by cell culture of a grade II chondrosarcoma excised as a whole from the public bone of a 59-year-old man. The OSHU-1 chondrosarcoma cell line was maintained in vitro for over 10 months and was invariably tumorigenic when injected in inbred BALB/c athymic nude mice. The karyotype was grossly abnormal and suggestive of a malignant growth. Scanning and transmission electron microscopy showed features commonly associated with malignant transformation. Transplants of the isolated tumor cells reproduced many of the microscopic, histochemical, and biosynthetic features of the original chondrosarcoma. Hydroxyproline and uronic acid rapidly accumulated between 2 and 3 weeks after transplantation. 35S uptake increased about 5,5-fold within 7 days after transplantation. After 4-6 weeks in athymic mice, the rate of growth of the chondrosarcoma reached a plateau. The interior of the tumor calcified, while on the surface the tumor induced the formation of new bone and bone marrow, apparently of host origin.
Human Immunodeficiency Virus Infections among Civilian Applicants for United States Military Service, October 1985 to March 1986
Authors: Donald S. Burke, John F. Brundage, John R. Herbold, William Berner, Lytt I. Gardner, Jeffrey D. Gunzenhauser, James Voskovitch, Robert R. Redfield
Journal: New England Journal of Medicine (1987)

During the six months from October 1985 through March 1986, blood samples from 306,061 civilian applicants for military service from the United States were tested for antibody to the human immunodeficiency virus (HIV). Four hundred sixty subjects were positive for the antibody as determined by Western (immune) blot reactivity. The mean prevalence of HIV infection in this population of teenagers and young adults was thus 1.50 per 1000. According to multivariate analysis, the following demographic factors were found to be significant independent predictors of a positive HIV-antibody test: age (adjusted odds ratio = 1.10 per year), black race (adjusted odds ratio = 2.04), male sex (adjusted odds ratio = 1.84), residence in a densely populated county (adjusted odds ratio = 1.05 per 1000 per square mile), and residence in a metropolitan area with a high incidence of the acquired immunodeficiency syndrome (adjusted odds ratio = 1.53). Antibody-positive applicants were identified in 43 of the 50 states. Counties with high prevalence rates for HIV (greater than 5 per 1000) were located in New York State (four counties), New Jersey (three counties), California (two counties), Maryland (two counties), and Texas, Colorado, and Washington, D.C.
Initial pulmonary toxicity evaluation of chemoradiotherapy (CRT) utilizing 74 Gy 3-dimensional (3-D) thoracic radiation in stage III non-small cell lung cancer (NSCLC): A Cancer and Leukemia Group B (CALGB) randomized phase II trial
Authors: A. W. Blackstock, M. A. Socinski, L. Gu, J. Rosenman, X. Wang, J. Bogart, E. Vokes, M. Green
Journal: Journal of Clinical Oncology (2005)

7060 Background: Concurrent CRT is an evidence-based treatment approach for patients with stage III NSCLC. Radiation dose escalation during the CRT may increase local control but be associated with increased toxicity. Single institution trials of induction chemotherapy followed by CRT utilizing 3-D conformal techniques with radiation doses ≥ 74 Gy have shown activity and acceptable toxicity. This CALGB randomized phase II trial evaluated this strategy in the cooperative group setting. Methods: Previously untreated stage III NSCLC patients with PS 0–1 were randomized to either 2 cycles of (Arm A) paclitaxel (P) 225 mg/m2 and carboplatin (C) AUC 6 IV on day 1 and 22 or (Arm B) gemcitabine (G)1000 mg/m2 d 1+8 plus C AUC 5 IV day 1 and 22. Patients without progression then received 74 Gy 3-D conformal thoracic radiation concurrent with (Arm A) P 45 mg/m2 IV/wk and C AUC 2 IV/wk x 7 wks or (Arm B) G 35 mg/m2 IV given twice-weekly for 7 wks. Pre-treatment PFT’s and calculation of lung volume receiving > 20 Gy (V20) in the initial radiation portals were mandatory. Results: Between 3/02 and 11/04, 69 patients were accrued (43 Arm A, 26 Arm B). Arm B was suspended in 3/04 following reports of grade 4/5 pulmonary toxicities. During or after CRT, 1 grade 4 dyspnea, 1 grade 4 penumonitis and 1 grade 4 hypoxia were observed on Arm A; 2 grade 4 and 1 grade 5 dyspnea and 2 grade 5 pneumonitis were observed on Arm B. The median pre-treatment FEV-1 (n=61) of eligible patients was not different between the treatment arms - 2.00 liters (Arm A) and 2.32 liters (Arm B). Four of 5 patients with grade 4 or 5 pulmonary toxicity had pre-treatment FEV 1 < 1.75 L or V20 of ≥ 40% (n=31). Four of 11 patients with a V20 > 40% experienced a grade 4/5 pulmonary toxicity vs. 1 of 31 patients if the V20 was < 40% (p=0.046). Conclusions: Following induction chemotherapy, CRT using twice-weekly gemcitabine and 74 Gy 3-D conformal radiation presents an unacceptable lethal pulmonary toxicity risk in stage III NSCLC patients. This is particularly true if the V20 is greater than 35%. A complete analysis of pulmonary toxicities for all 69 patients will be presented. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Eli Lilly Oncology Eli Lilly Oncology
A Consideration of Improved Methods of Nebulization Therapy
Authors: William F. Miller
Journal: New England Journal of Medicine (1954)

INCREASING interest in the pathologic physiology of chronic bronchopulmonary disease has opened the way for more enthusiastic treatment of such conditions as chronic bronchitis, bronchiectasis, asthma and emphysema. Barach and his associates,1 , 2 Segal and Dulfano3 and Harvey, Ferrer and Cournand4 have emphasized the reversibility of many of the severe states that characterize these disorders.Nebulization and inhalation of various drugs is usually a very effective method of therapy when used properly in these diseases. On the other hand only transient or incomplete benefits result from nebulization therapy if the nebulizers are employed improperly.The purpose of this report is to . . .
Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure
Authors: Jay N. Cohn, T. Barry Levine, Maria Teresa Olivari, Victoria Garberg, Dennis Lura, Gary S. Francis, Ada B. Simon, Thomas Rector
Journal: New England Journal of Medicine (1984)

Hemodynamics, plasma norepinephrine, and plasma renin activity were measured at supine rest in 106 patients (83 men and 23 women) with moderate to severe congestive heart failure. During follow-up lasting 1 to 62 months, 60 patients died (57 per cent); 47 per cent of the deaths were sudden, and 45 per cent were related to progressive heart failure. Statistically unrelated to the risk of mortality were cause of disease (60 patients had coronary disease, and 46 had cardiomyopathy), age (mean, 54.8 years), cardiac index (mean, 2.11 liters per minute per square meter of body-surface area), pulmonary wedge pressure (mean, 24.5 mm Hg), and mean arterial pressure (mean, 83.2 mm Hg). A multivariate analysis of the five significant univariate prognosticators—heart rate (mean, 84.4 beats per minute), plasma renin activity (mean, 15.4 ng per milliliter per hour), plasma norepinephrine (mean, 700 pg per milliliter), serum sodium (mean, 135.7 mmol per liter), and stroke-work index (mean, 21.0 g-meters per square meter) — found only plasma norepinephrine to be independently (P = 0.002) related to the subsequent risk of mortality. Norepinephrine was also higher in patients who died from progressive heart failure than in those who died suddenly. These data suggest that a single resting venous blood sample showing the plasma norepinephrine concentration provides a better guide to prognosis than other commonly measured indexes of cardiac performance. (N Engl J Med 1984; 311:819–23.)
The Treatment of Acute Granulocytic Leukemia in Adults
Authors: David S. Rosenthal, William C. Moloney
Journal: New England Journal of Medicine (1972)

A chemotherapy program used over the past 18 months in 23 previously untreated cases of adult acute granulocytic leukemia consisted of vincristine, cytosine arabinoside and daunorubicin administered over a period of three to six days. Complete remissions were attained in 55 per cent of cases. Survival time among 11 patients achieving complete remission averaged 11 months, with six patients still alive. Although efforts to maintain remission were unsuccessful, retreatment with a full course of the combined drug program reinduced complete remission in five of seven attempts. The short induction period and relatively high remission rate encourages more extensive trials with this combined chemotherapy program.