tbuckley/cabot-search huggingface dataset:
Assessing the needs of long-term breast cancer survivors
Authors: A. M. Lopez, D. J. Avery, M. B. Hofacre
Journal: Journal of Clinical Oncology (2005)

817 Background: With improved therapies, methods of detection, and supportive care systems, the number of long-term breast cancer survivors has grown steadily. Existing data have not focused on the needs of special populations, such as, Latinos along the Arizona/US-Mexico border. Methods: In order to strategize interventions, focus groups with long-term breast cancer survivors (> 5 years since diagnosis) in rural and urban communities along the Arizona/US-Mexico border were conducted. Survivors were asked to identify persistent physical, psychological, or cognitive symptoms, type and stability of social support systems, ongoing financial issues related to the cancer diagnosis, and valuable existing or potential resources. Participants were recruited via community and clinical centers. Focus groups were conducted with a trained and independent facilitator in the participant’s preferred language. The focus group interaction was either audio or video recorded, transcribed, and analyzed using Ethnograph qualitative software. 47 women have participated: urban (23 Anglo, 8 Latina), rural (16 Latina). Results: Women reported similar physical, psychological and cognitive symptoms. Physical symptoms included pain at the surgery or radiation site, myalgias, arthralgias, neuropathy and lymphedema. Depression and anxiety were commonly reported. Anxiety was particularly centered on the possibility of recurrence. Memory loss and confusion were reported. Latinas living in rural areas were more likely to report financial difficulties, and a lack of needed resources, including transportation, and educational resources. Women expressed the need for support services for friends and family members. They also discussed the need for ongoing support. Conclusions: The issues faced by long-term breast cancer survivors are similar for women living in rural and urban areas however access to resources to address these self-identified needs differs. No significant financial relationships to disclose.
Conformation of oligonucleotides and nucleic acids modified with 2-aminofluorene or 2-acetylaminofluorene
Authors: Pascale Rio, Bernard Malfoy, Evelyne Sage, Marc Leng
Journal: Environmental Health Perspectives (1983)

The first part of this work deals with the thermal stability of oligonucleotides modified with acetylaminofluorene and aminofluorene, respectively. The complementary oligonucleotides d(CGCG), d(CGTACG) and d(AATTGCAATT) have been studied by ultraviolet absorption and circular dichroism. In high salt concentration and at low temperature, the three oligonucleotides form double-stranded helices which have the B-form Substitution of guanine residues in these oligonucleotides by acetylated or deacetylated aminofluorene residues destablizes the B-form and does not induce the transition to the Z-form. The second part of the work deals with the antibodies to Z-DNA. The specificity of these antibodies has been determined by radioimmunoassay. The antibodies react with the Z-form but not with the B-form. Poly(dG-dC).poly(dG-dC) modified by acetylaminofluorene residues is recognized by the antibodies. The antibodies can detect the Z-form in natural DNA as visualized by fluorescent staining of polytene chromosomes from Drosophila melanogaster.
THE IMPACT OF DIABETES ON CORONARY PLAQUE PROGRESSION ASSESSED BY NOVEL SEMI-AUTOMATED QUANTITATIVE PLAQUE SOFTWARE ON CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY
Authors: Rine Nakanishi, Kendall Kissel, Yanting Luo, Yesseina Ortega, Shriraj S. Susaria, Zeus Fernandez, Nichell Megowan, Negin Nezarat, Sina Rahmani, Mitsuru Kanisawa, Indre Ceponiene, Alexander Broersen, Pieter Kitslaar, Jeby Abraham, Christopher Dailing, Matthew Budoff
Journal: Journal of the American College of Cardiology (2016)
Supernumerary Parathyroid Glands in Recurrent Secondary Hyperparathyroidism
Authors: ANNE KIRSTINE ARVESCHOUG, JENS BRØCHNER-MORTENSEN, HENRIK BERTELSEN, BIRTHE VAMMEN
Journal: Clinical Nuclear Medicine (2002)

KIRSTINE ARVESCHOUG, ANNE M.D.; BRØCHNER-MORTENSEN, JENS M.D., D.M.Sc.; BERTELSEN, HENRIK M.D., Ph.D.; VAMMEN, BIRTHE M.D. Author Information
Tc-99m MDP Uptake in a Giant Pulmonary Chondroma
Authors: Guangjie Yang, Xufu Wang, Zhenguang Wang, Yanxia Jiang, Junhua Fu
Journal: Clinical Nuclear Medicine (2011)

Pulmonary chondromas are very rare benign tumors. We report a case of huge solitary pulmonary chondroma in a 53-year-old woman without specific symptom. The lesion was detected by CT and Tc-99m methylene diphosphonate bone scintigraphy. The primary diagnosis after radiologic examination was pulmonary hamartoma. Then, surgical excision was performed, and the pathology showed pulmonary chondroma.
Abstract 780: Dimethyl cardamonin induces G1-phase cell cycle arrest, apoptosis, and autophagy in HCT116 cells
Authors: Hyeonseok ko, Young-Joo Kim, Jin-Soo Park, Evangeline C Amor, Jong Wha Lee, Hyun Ok Yang
Journal: Cancer Research (2010)

Abstract Dimethyl cardamonin (2’,4’-dihydroxy-6’-methoxy-3’,5’-dimethylchalcone; DMC) is a naturally occurring chalcone, and it is the major compound isolated from the leaves and/or fruits of Syzygium samarangense (Blume) Merr. &amp; L.M. Perry (Myrtaceae). DMC has been reported to have anti-diabetic, anti-bacterial, spasmolitic and anti-tumor properties. Furthermore, it has been used as an antipyretic and a diuretic agent in Taiwan folk medicine. However, the underlying mechanisms of its anti-tumor effects have not been studied. Here, we report that DMC induced G1 phase arrest, apoptosis and autophagy in HCT116 cell line. In this study, DMC decreased the expression of the phospho-Rb, CDK4 and cyclin D1 expression level, which is correlated with G1 phase. We also found that DMC-induced apoptosis occurred through the p53 dependent manner and the mitochondrial death pathway as evidenced by reduction of the Bcl2, XIAP and caspase-9 activation, and by induction of Bims. And, we showed that DMC up-regulates activity of JNK and p38. Interestingly, we found that DMC elicits autophagy, a process that participates in apoptotic response, in a JNK and p53-dependent manner, in HCT116 cell line. We also found that the increased activation of JNK by DMC is partially regulated by p53, highlighting the relationship of JNK and autophagy to p53 signaling pathway. The treatment of HCT116 (p53 -/-) cell line with DMC resulted in reduction in both apoptotic and autophagic effects relative to HCT116 (p53 +/+) cell line. This study suggested that DMC induced the multiple effects of G1 phase arrest, apoptosis and autophagy through JNK and p53 in HCT 116 cell line. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 780.
S115 The effect of posture on the 2nd intercostal space surface parasternal electromyogram (EMGpara): validating a novel clinical tool to measure neural respiratory drive
Authors: M. C. Ramsay, E.-S. Suh, S. Mandal, P. Murphy, J. Steier, A. Simonds, N. Hart
Journal: Thorax (2011)

<h3>Introduction</h3> Although neural respiratory drive (NRD), as measured by diaphragm EMG, has been shown to reflect the balance between the respiratory muscle load and capacity providing a marker of disease severity, it requires insertion of an oesophageal catheter which limits its clinical utility. 2nd intercostal space surface EMGpara has been shown to be a useful alternative non-invasive monitoring tool in acute COPD (Murphy <i>et al. Thorax</i> 2011;<b>66</b>:602–8) and overnight in asthmatic patients (Steier <i>et al. Thorax</i> 2011;<b>66</b>:609–14). Previous data has suggested that there is reduced activation of the chest wall muscles in normal subjects in the supine posture as a consequence of a change in chest wall configuration. To assess the clinical utility and validity of EMGpara to continuously monitor changes in NRD, we investigated the effect of different posture on the EMGpara in normal subjects. <h3>Methods</h3> Wet gel electrodes were placed at the parasternal edge of the 2nd intercostal space following skin preparation. Signals were amplified and filtered before analogue to digital conversion and digital processing providing the raw signal and root mean squared data. Five positions included sitting at 45 degrees, lying flat, lying on the right and left hand side and sitting at 90 degrees. EMGpara was measured during 2 min of tidal breathing in each posture. Resting EMG signal was normalised to the maximal inspiratory manoeuvres performed in each position (EMGpara%max). <h3>Results</h3> Eight healthy subjects were recruited with a mean age 32 years ±2 years; 4 male; BMI 23±2 kg/m<sup>2</sup>. Mean EMGpara%max was 4.60±3.93% sitting at 45 degrees, 4.82±2.27% lying flat, 5.32±3.91% lying on the right hand side, 4.47±4.47% lying on the left hand side, 4.58±3.75% sitting at 90 degrees. A repeated measures ANOVA showed there was no significant difference in EMG<sup>para%max</sup> between the different postures (p= 0.97; Abstract S115 figure 1). <h3>Conclusion</h3> NRD, as measured by EMG<sub>para%max</sub>, is stable across a range of different postures. It provides comparable information independent of body position and could be considered as a monitoring tool in clinical practice, including for overnight monitoring.
Parafibromin as a new immunohistochemistry staining to improve pathologic diagnosis of renal oncocytoma: Analysis of 225 renal tumors.
Authors: L. Albiges, J. Couturier, Y. Allory, P. Camparo, M. Sibony, A. Vieillefond, B. T. Teh, B. J. Escudier, V. Molinie
Journal: Journal of Clinical Oncology (2011)

408 Background: Chromophobe renal cell carcinoma (chRCC) and renal oncocytoma (Onc) are two distinct but closely related entities with strong morphologic and genetic similarities. While chRCC is a malignant tumor, Onc is usually considered as a benign entity. Recently, gene expression profiling applied on chRCC and Onc identified new potential markers that may effectively discriminate the 2 pathologic entities, including parafibromin. This work aims at evaluating the diagnostic value of Parafibromin (Pf) immuno staining on a large number of renal tumor samples. Methods: Sixty-three renal clear cell carcinoma (ccRCC), 47 papillary (Pap), 40 chRCC, and 75 Onc were immunostained for parafibromin antibody (1/200; Santacruz Biotechnology), on a tissue micro array. Results: Parafibromin was positive in 38.6% of Onc, vs 5% of chRCC (p &lt; 0.001), with a 95% specificity, and the positive predictive value observed for parafibromin was 94%. For other tumor types, a positive staining for parafibromin was observed in 7.9% and 8.5% in ccRCC and Pap respectively. Conclusions: Parafibromin is a recently identified protein which seems to be specific for oncocytoma, and highly discriminant for other histologic renal cell tumor subtypes, especially for chromophobe. IHC may help to optimize therapeutics strategy for small renal mass and avoid surgical resection of benign lesions in some patients.Validation of this staining on renal tumor biopsies is on going.The value of the combination of this new immunostaining associated with the three standard IHC staining (CK7, CD117, E Cad) will be provided at the meeting. [Table: see text] No significant financial relationships to disclose.
Abstract 4331: Analysis of stem cell-like compartments in Embryonal Rhabdomyosarcoma modulated by Sonic Hedgehog signaling
Authors: Sampoorna Satheesha, Dagmar Walter, Beat Bornhauser, Beat W. Schäfer
Journal: Cancer Research (2012)

Abstract Rhabdomyosarcoma (RMS) is a heterogeneous group of malignancies with features of impaired skeletal muscle differentiation and represents the majority of the soft tissue cancers in the pediatric age group. Current treatment regimens offer some clinical respite but at a significant risk of averse side effects and secondary tumors later in life. Identifying and targeting sub-populations with higher tumorigenic potential and self renewal capacity not only decreases tumor burden but also lowers the probability of relapse. Using the sphere formation assay we could select for self-renewing cells from the heterogeneous monolayer cultures of embryonal RMS cell lines, RD and Rh36, which had multipotent differentiation ability in vitro and greater tumorigenic potential in vivo. Preliminary results suggest that the self renewing ability of RMS cells could be modulated by Hedgehog signaling, a developmental pathway important in RMS biology. Microarray analysis of the sphere cultures revealed Prominin 1 (CD133) as one of the surface markers with significantly higher expression. The CD133-positive cellular sub-population was more resistant to DNA damaging agents and had a greater capacity for tumor formation in an orthotopic xenotransplantation model. Embryonal RMS patients with higher expression of CD133 had a significantly lower overall survival. Ongoing work seeks to validate the importance of Hedgehog signaling in the embryonal RMS stem cell-like compartment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4331. doi:1538-7445.AM2012-4331
INTERLEUKIN-6 IS ASSOCIATED WITH, BUT DOES NOT INDEPENDENTLY PREDICT, MORTALITY IN ACUTE HEART FAILURE: AN ASCEND-HF SUBSTUDY
Authors: Antonio Perez, Justin Grodin, Adrian Hernandez, Javed Butler, Marco Metra, G. Michael Felker, Adriaan A. Voors, John McMurray, Paul W. Armstrong, Robert Califf, Randall Starling, Christopher O’Connor, Wai Hong Tang
Journal: Journal of the American College of Cardiology (2015)
Sentinel Lymph Node Biopsy in Breast Cancer
Authors: Gianpiero Manca, Domenico Rubello, Elisa Tardelli, Francesco Giammarile, Sara Mazzarri, Giuseppe Boni, Sotirios Chondrogiannis, Maria Cristina Marzola, Serena Chiacchio, Matteo Ghilli, Manuela Roncella, Duccio Volterrani, Patrick M. Colletti
Journal: Clinical Nuclear Medicine (2015)

Axillary lymph node status, a major prognostic factor in early-stage breast cancer, provides information important for individualized surgical treatment. Because imaging techniques have limited sensitivity to detect metastasis in axillary lymph nodes, the axilla must be explored surgically. The histology of all resected nodes at the time of axillary lymph node dissection (ALND) has traditionally been regarded as the most accurate method for assessing metastatic spread of disease to the locoregional lymph nodes. However, ALND may result in lymphedema, nerve injury, shoulder dysfunction, and other short-term and long-term complications limiting functionality and reducing quality of life. Sentinel lymph node biopsy (SLNB) is a less invasive method of assessing nodal involvement. The concept of SLNB is based on the notion that tumors drain in an orderly manner through the lymphatic system. Therefore, the SLN is the first to be affected by metastasis if the tumor has spread, and a tumor-free SLN makes it highly unlikely for other nodes to be affected. Sentinel lymph node biopsy has become the standard of care for primary treatment of early breast cancer and has replaced ALND to stage clinically node-negative patients, thus reducing ALND-associated morbidity. More than 20 years after its introduction, there are still aspects concerning SLNB and ALND that are currently debated. Moreover, SLNB remains an unstandardized procedure surrounded by many unresolved controversies concerning the technique itself. In this article, we review the main indications, contraindications, and controversies of SLNB in breast cancer in the light of the most recent publications.
Abstract 201: (-)-Epigallocatechin-3-gallate inhibits the development of hepatic preneoplastic lesions in obese and hypertensive rats, a novel model of non-alcoholic steatohepatitis-related liver tumorigenesis.
Authors: Takahiro Kochi, Masahito Shimizu, Takuji Tanaka, Hisataka Moriwaki
Journal: Cancer Research (2013)

Abstract Background: Non-alcoholic steatohepatitis (NASH), which involves hepatic inflammation and fibrosis, is associated with liver carcinogenesis. The activation of the renin-angiotensin system (RAS), which plays a key role in blood pressure regulation, promotes hepatic fibrogenesis. In this study, we investigated the effects of (-)-epigallocatechin-3-gallate (EGCG), a major component of green tea catechins, on the development of hepatic preneoplastic lesions in SHRSP.Z-Leprfa/IzmDmcr (SHRSP-ZF) obese and hypertensive rats. Methods: Male 7-week-old SHRSP-ZF rats and control non-obese and normotensive WKY/Izm rats were fed a high fat diet and received intraperitoneal injections of carbon tetrachloride twice a week for 8 weeks. The rats were also provided tap water containing 0.1% EGCG during the experiment. Results: SHRSP-ZF rats presented with obesity, insulin resistance, dyslipidemia, an imbalance of adipokines in the serum, and hepatic steatosis. The development of hepatic preneoplastic lesions and liver fibrosis was markedly accelerated in SHRSP-ZF rats compared to that in control rats. Additionally, in SHRSP-ZF rats, RAS was activated and inflammation and oxidative stress were induced. Administration of EGCG, however, inhibited the development of hepatic premalignant lesions by improving liver fibrosis, inhibiting RAS activation, and attenuating inflammation and oxidative stress in SHRSP-ZF rats. Conclusions: Obese and hypertensive SHRSP-ZF rats treated with a high fat diet and carbon tetrachloride displayed the histopathological and pathophysiological characteristics of NASH and developed hepatic premalignant lesions, suggesting the model might be useful for the evaluation of NASH-related liver tumorigenesis. EGCG might also be able to prevent NASH-related liver fibrosis and tumorigenesis. Citation Format: Takahiro Kochi, Masahito Shimizu, Takuji Tanaka, Hisataka Moriwaki. (-)-Epigallocatechin-3-gallate inhibits the development of hepatic preneoplastic lesions in obese and hypertensive rats, a novel model of non-alcoholic steatohepatitis-related liver tumorigenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 201. doi:10.1158/1538-7445.AM2013-201
Utility of 11C-Choline Imaging as a Supplement to F-18 FDG PET Imaging for Detection of Thyroid Carcinoma
Authors: Hu-bing Wu, Quan-shi Wang, Min-fang Wang, Hong-sheng Li
Journal: Clinical Nuclear Medicine (2011)

Purpose: We present 4 patients with thyroid carcinoma who underwent 11C-choline PET/CT for the detection of their primary tumor and its metastases. Previous F-18 FDG PET had shown no abnormal tracer uptake in the lesions in 3 patients and only mild uptake in 1 patient. Materials and Methods: Four patients aged between 24 and 59 years (2 newly diagnosed and 2 with recurrence) underwent whole-body F-18 FDG PET/CT. The patients then underwent regional 11C-choline PET/CT imaging on a separate day. Results: All of the lesions in 4 patients were 11C-choline avid except for a few small lung metastases. The SUVmax of the lesions was 7.94 ± 4.93. 11C-choline imaging detected 3 primary tumors in 4 patients, 1 tumor in the tracheal wall in 1 patient, 7 cervical lymph nodes metastases in 3 patients, and several lung metastases in 1 patient. Conclusions: 11C-choline PET/CT may be a promising supplement to F-18 FDG PET/CT in the detection of thyroid carcinoma and its metastases.
Prenatal Exposure to Stilbestrol
Authors: Arthur L. Herbst, David C. Poskanzer, Stanley J. Robboy, Lawrence Friedlander, Robert E. Scully
Journal: New England Journal of Medicine (1975)

Abstract The effects of prenatal exposure to diethylstilbestrol were studied by a prospective cohort investigation of 110 exposed and 82 unexposed females. The general health characteristics of mothers and daughters in both groups were similar. Among the exposed, there were striking benign alterations of the genital tract, which included transverse ridges (22 per cent), abnormal vaginal mucosa (56 per cent), and biopsy-proved adenosis (35 per cent). Among the unexposed there were no ridges and one case of vaginal mucosal abnormality including adenosis (p < 0.0001). Abnormal cervical epithelium occurred in almost all exposed subjects but in only half the unexposed (p < 0.0001). The incidence of vaginal adenosis was highest when diethylstilbestrol was begun in early pregnancy. It was not detected when treatment was initiated in the 18th week or later. Oral contraceptive use and prior pregnancy were associated with less adenosis and erosion, respectively (p <0.05). No cases of cancer were observed. (N Engl J...
SP0187 Imputation of Missing Data
Authors: M. Lunt
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Missing data is very common problem in epidemiological studies, and this problem can affect both the accuracy and the precision of any estimates generated from the study data. The magnitude of the problem will depend to some extent on whether the missing data refer to outcomes, exposures or confounders. There are a number of simple methods commonly used for analysing incomplete data, but which rely on unrealistic assumptions about the mechanism causing the data to be missing. Multiple imputation is a more sophisticated method which can produce precise, reliable estimates in a wide range of circumstances, but still relies on unverifiable assumptions about the missing data. I will outline the problems caused by missing data, and explain when simpler methods of analysing incomplete data would be appropriate. I will also explain the idea behind multiple imputation, and the situations in which it can be used effectively. I will illustrate the differences between conventional analyses and multiple imputations analyses, and show how to interpret the results of multiple imputation. My aim is that you will leave able to confidently decide whether it would be appropriate to use multiple imputation to deal with missing data in a given situation, and to understand the statistical output it generates. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6211
Liver Cancer Researchers Linking Risk Factors to Prevention, Genetics
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Liver Cancer Researchers Linking Risk Factors to Prevention, Genetics Get access Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 21, 4 November 1992, Pages 1619–1620, https://doi.org/10.1093/jnci/84.21.1619 Published: 04 November 1992