tbuckley/cabot-search huggingface dataset:
PTH-071 A multidisciplinary virtual biologics clinic: is it worthwhile?
Authors: J Duncan, S Caulfield, A Clark, S Anderson, J Sanderson, P Irving
Journal: Gut (2010)

<h3>Introduction</h3> While effective, biologics are associated with potentially serious side effects. Data regarding issues such as dose escalation, the use of concomitant immunomodulation (IM) and exit strategies emerge on a regular basis. Accordingly, regular review of patients on biologics is necessary but, due to service limitations, may be difficult. We assessed whether our recently introduced Virtual Biologics Clinic (VBC) was an effective tool in managing these patients. <h3>Methods</h3> The VBC is a multidisciplinary meeting comprising 3 Consultant Gastroenterologists, a Clinical Nurse Specialist and a Specialist Pharmacist. It meets weekly for 1 h and reviews the cases of all patients who have received infliximab (IFX) that week and one-eighth of the patients taking adalimumab (ADA) in rotation. It also reviews patients being considered for biologics and ensures that appropriate screening has occurred. We reviewed the results of our VBC for the period May to October 2009 and assessed whether the meeting had resulted in a management-changing decision. <h3>Results</h3> 72 patients (35 male, age 32(17-63) (median (range)) with IBD (65 Crohn9s, 1 IBDU, 6 OFG) were reviewed 178 times (2(0–5)). At the start of the 6 months, 40 patients were receiving IFX and 17 ADA, for a median of 12 (1–96) months. 15 patients started treatment during the period (13 IFX, 2 ADA). Concomitant IM was used in 48 patients. In the VBC, decisions regarding dose alteration were made on 20 occasions (dose increase 7, decrease 5; interval decrease 3, increase 5). 3 patients were withdrawn from treatment (loss of response-2, trial of withdrawal-1). The biologic was changed in three cases. Endoscopy was requested in nine cases, MRI in 5 and an urgent clinic appointment was made in 19. Referrals to other specialists were made on five occasions. 94 other management decisions were made including decisions regarding the need for concomitant IM (25), optimisation of IM (21), exit strategy (9), treatment of anaemia (9) and adherence issues (4). A total of 159 management decisions were made in 53 patients. In addition, the decision to start biologics was reviewed in 23 cases and agreed in 21, all of whom received appropriate screening. <h3>Conclusion</h3> The VBC is an effective forum in which to make management decisions. It prevents unnecessary clinic appointments but ensures that patients receiving biologics are regularly reviewed. Given the limited data regarding, and rapid evolution of, management strategies for patients receiving biologics, individualised rather than protocol-led care is appropriate. The VBC has the advantage over outpatient clinics of ensuring that complex management decisions are reviewed by a mulitdisciplinary team.
HIV testing
Authors: Kaveh Manavi, Philip D Welsby
Journal: BMJ (2005)

public health experts.General practitioners and other clinicians need to be aware that anyone who has been scratched or bitten by a bat or whose eyes, broken skin, or mucous membrane have come in contact with bat saliva or neural tissue from a bat should be offered post-exposure rabies vaccination as soon as possible.Immunoglobulin may also be given if the bat is known or strongly suspected to be rabid.Detailed advice on post exposure prophylaxis is now available for clinicians in the revised Green Book's chapter on rabies and also advice on the public health management of a case of human rabies. 9 10The Department for Environment Food and Rural Affairs has also published a draft rabies contingency plan for consultation. 11he risk to public health needs to be put in context.Only licensed or volunteer bat handlers will routinely come into contact with bats.Current advice from the Department of Health says that all bat handlers should be vaccinated before exposure and should wear bite proof gloves when handling bats.Daubenton's bats are one of 16 species of bats in the United Kingdom and, unlike pipistrelles (Pipistrellus species) and long eared bats (Plecotis auritus), rarely roost in houses or come in contact with people.In the United Kingdom, pipistrelles and long eared bats have to date not been found to harbour European bat lyssaviruses.Therefore the likelihood of a member of the public coming into contact with an infected bat is small.Bats excreting European bat lyssaviruses in saliva are more than likely to show abnormal behaviour such as flying during daylight or being grounded or paralysed.A sick or injured bat should therefore never be handled by a member of the public but rather reported to either the Bat Conservation Trust (tel 0845 1300228), the Scottish Society for the Protection of Cruelty to Animals (tel 0870 7377722), or the relevant animal health divisional office.We need to raise awareness in the general public of this small risk to human health without creating a fear of bats, which are a protected species under the Wildlife and Countryside Act 1981.Similarly, awareness among health professionals of current post exposure regimens also needs to be raised as rabies due to European bat lyssaviruses seems to be similar to classical rabies in being incurable but completely preventable. 12
NIMG-16PSEUDOPROGRESSION AND IMMUNOTHERAPY IN GLIOBLASTOMA: A CASE SERIES FROM COHORT 1 OF CHECKMATE-143 (NCT02017717)
Authors: Solmaz Sahebjam, Antonio Omuro, Joachim Baehring, John Sampson, Gordana Vlahovic, Alfredo Voloschin, Wendy Hayes, Robert Latek, Vlad Coric, Timothy Cloughesy, Michael Lim, David A. Reardon
Journal: Neuro-Oncology (2015)

BACKGROUND: In CHECKMATE-143, safety and tolerability of nivolumab and ipilimumab were evaluated in patients with first recurrence of glioblastoma. One of the challenges with immune targeting therapies is the accurate assessment of changes in disease progression with neuroimaging. Immune-related treatment effects presenting as temporary increases in target or non-target lesions or a transient appearance of a new lesion are observed in ∼10% of patients. These changes can result from influx of inflammatory cells leading to temporary appearances of increased mass. Here, we present neuroimaging results that meet RANO criteria for progressive disease, and the corresponding histopathology findings. METHODS: In cohort 1, eligible patients were randomized 1:1 to nivolumab 3mg/kg Q2W or nivolumab 1 mg/kg + ipilimumab 3 mg/kg Q3W followed by nivolumab 3 mg/kg Q2W. Responses were assessed using RANO criteria at Weeks 6, 12, and Q8W onward. Treatment beyond progression was permitted until a second radiologic confirmation of progression 8 weeks later. At the time of imaging progression, if biopsy/resection was feasible, pathological evaluation was performed and histopathologic findings were correlated with imaging changes. RESULTS: A total of 20 patients were treated in cohort 1. In some cases, immune-related treatment effects presenting as target lesion growth or appearance of new lesions were observed on imaging. A variety of histopathologic patterns were observed with radiographic progression. Imaging and the correlated histopathological findings will be presented in detail. CONCLUSIONS: Immune-related treatment effects can occur in patients with glioblastoma receiving checkpoint inhibitors. Tissue acquisition and pathologic assessment can clarify the etiology of progression imaging findings preventing premature discontinuation of potentially beneficial therapy.
Beauty That Is More Than Skin Deep
Authors: Jorge Roman
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Mesenchymal stem cell therapy for acute radiation syndrome
Authors: Risaku Fukumoto
Journal: Military Medical Research (2016)

Acute radiation syndrome affects military personnel and civilians following the uncontrolled dispersal of radiation, such as that caused by detonation of nuclear devices and inappropriate medical treatments. Therefore, there is a growing need for medical interventions that facilitate the improved recovery of victims and patients. One promising approach may be cell therapy, which, when appropriately implemented, may facilitate recovery from whole body injuries. This editorial highlights the current knowledge regarding the use of mesenchymal stem cells for the treatment of acute radiation syndrome, the benefits and limitations of which are under investigation. Establishing successful therapies for acute radiation syndrome may require using such a therapeutic approach in addition to conventional approaches.
A computational model to predict severity of atopic eczema from 30 serum proteins
Authors: Linda Krause, Vagkan Mourantchanian, Knut Brockow, Fabian J. Theis, Carsten B. Schmidt-Weber, Bettina Knapp, Nikola S. Mueller, Stefanie Eyerich
Journal: Journal of Allergy and Clinical Immunology (2016)
Proton Pump Inhibitors Accelerate Endothelial Senescence
Authors: Gautham Yepuri, Roman Sukhovershin, Timo Z. Nazari-Shafti, Michael Petrascheck, Yohannes T. Ghebre, John P. Cooke
Journal: Circulation Research (2016)

Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.
Case 7-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, James T. Willerson, Benjamin Castleman
Journal: New England Journal of Medicine (1972)

Presentation of Case First admission. A 67-year-old woman was admitted to the hospital because of dyspnea.She had been well until six years previously, when a cardiac murmur was first found on a routine examination. One year before admission she became aware of exertional dyspnea, which progressed to the extent that she could not climb more than one flight of stairs. Eight months before admission she began to experience a "tight" sensation in the neck when walking up a minimal inclination. Two months later, after exertion, she almost fainted. Two months before entry digoxin and chlorothiazide were begun, with . . .
<i>Notes from the Field</i>: Probable Mucormycosis Among Adult Solid Organ Transplant Recipients at an Acute Care Hospital — Pennsylvania, 2014–2015
Authors: Shannon A. Novosad, Amber M. Vasquez, Atmaram Nambiar, Matthew J. Arduino, Erick Christensen, Heather Moulton-Meissner, M. Shannon Keckler, Jeffrey Miller, Joseph F. Perz, Shawn R. Lockhart, Tom Chiller, Carolyn Gould, Lynne Sehulster, Mary E. Brandt, J. Todd Weber, Alison Laufer Halpin, Rajal K. Mody
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

On September 17, 2015, the Pennsylvania Department of Health (PADOH) notified CDC of a cluster of three potentially health care-associated mucormycete infections that occurred among solid organ transplant recipients during a 12-month period at hospital A. On September 18, hospital B reported that it had identified an additional transplant recipient with mucormycosis. Hospitals A and B are part of the same health care system and are connected by a pedestrian bridge. PADOH requested CDC's assistance with an on-site investigation, which started on September 22, to identify possible sources of infection and prevent additional infections.
Angiogenesis and breast cancer.
Authors: J Folkman
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.3.441 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7509850 Angiogenesis and breast cancer. J FolkmanxJ FolkmanSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.3.441 First Page PDF © 1994 by American Society of Clinical Oncology
Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Authors: Tuhina Neogi, Ali Guermazi, Frank Roemer, Michael C. Nevitt, Joachim Scholz, Lars Arendt‐Nielsen, Clifford Woolf, Jingbo Niu, Laurence A. Bradley, Emily Quinn, Laura Frey Law
Journal: Arthritis & Rheumatology (2015)

Objective Pain sensitization is associated with pain severity in knee osteoarthritis (OA), but its cause in humans is not well understood. We examined whether inflammation, assessed as synovitis and effusion on magnetic resonance imaging (MRI), or mechanical load, assessed as bone marrow lesions (BMLs), was associated with sensitization in knee OA. Methods Subjects in the Multicenter Osteoarthritis Study, a National Institutes of Health–funded cohort of persons with or at risk of knee OA, underwent radiography and MRI of the knee, and standardized quantitative sensory testing (temporal summation and pressure pain threshold [PPT]) of the wrist and patellae at baseline and 2 years later. We examined the relation of synovitis, effusion, and BMLs to temporal summation and PPT cross‐sectionally and longitudinally. Results There were 1,111 subjects in the study sample (mean age 67 years, mean body mass index 30 kg/m 2 , 62% female). Synovitis was associated with a significant decrease in PPT at the patella (i.e., more sensitized) over 2 years (adjusted β −0.30 [95% confidence interval (95% CI) −0.52, −0.08]). Effusion was similarly associated with a decrease in PPT at the wrist (adjusted β −0.24 [95% CI −0.41, −0.08]) and with risk of incident temporal summation at the patella (adjusted OR 1.54 [95% CI 1.01, 2.36]). BMLs were not associated with either quantitative sensory testing measure. Conclusion Inflammation, as evidenced by synovitis or effusion, is associated with pain sensitization in knee OA. In contrast, BMLs do not appear to contribute to sensitization in knee OA. Early targeting of inflammation is a reasonable strategy to test for prevention of sensitization and through this, reduction of pain severity, in knee OA.
Di braves minefield
Authors: V. Nathanson
Journal: BMJ (1997)

For five days the British media were full of pictures from Angola of Diana, Princess of Wales, as she visited hospitals, rehabilitation centres, and other sites showing the devastation caused by antipersonnel landmines in that war ravaged country.

The Princess is a magnet for the British media. She is considered newsworthy regardless of the occasion, and her picture on the cover is said to increase the sales of most magazines. Her picture, associated with the tragic results of mines in Angola, has brought landmines to the notice of an audience which would never otherwise have seen them.

Would the pictures and reports of her visit have occupied the front pages of the papers, and prime slots in television news programmes, had an unnamed government minister (possibly Earl Howe) not criticised her for entering the forbidden field of party politics? His comments over lunch with journalists–published in the Daily Telegraph: “Lord Howe made clear that senior defence figures were ‘angered’ by the Princess's backing for the …
Kids, cancer, and the Joe Camel connection.
Authors: H K Koh
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.6.2181 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9196129 Kids, cancer, and the Joe Camel connection. H K KohxH K KohSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.6.2181 PDF "Kids, cancer, and the Joe Camel connection.." Journal of Clinical Oncology, 15(6), pp. 2181–2182© 1997 by American Society of Clinical Oncology
Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection
Authors: Gratiela Pircalabioru, Gabriella Aviello, Malgorzata Kubica, Alexander Zhdanov, Marie-Helene Paclet, Lorraine Brennan, Rosanne Hertzberger, Dmitri Papkovsky, Billy Bourke, Ulla G. Knaus
Journal: Cell Host & Microbe (2016)
Chemosensitivity testing of docetaxel and paclitaxel for gastric cancer using the Histoculture Drug Response Assay
Authors: Y. Kodera, N. Ohashi, K. Hibi, S. Akiyama, K. Ito, A. Nakao
Journal: Journal of Clinical Oncology (2004)

4194 Background: In vitro chemosensitivity testing for individualized chemotherapy is known to improve the reponse rates although the impact on survival has not been adequately addressed. In vitro testing concentrations for new anticancer drugs such as the taxanes are unknown. Methods: Chemosensitivity tests for 30 gastric carcinoma tissues obtained at surgery were performed with Histoculture Drug Response Assay (HDRA) at 150μg/mL for 5FU and at three different concentrations for docetaxel (3, 30, 100 μg/mL) and paclitaxel (10, 60, 100 μg/mL). Inhibition rates (IR) were calculated using the formlula: (1-A/B) × 100% where A and B represent the mean absorbances of drug-treated and control wells, respectively. Results: For both drugs, the inhibition rates rose significantly as the testing concentration was elevated. Valid testing concentrations were determined as 10 μg/mL for paclitaxel and 30 μg/mL for docetaxel, based on the distribution of IRs between 0 and 100%. Five, 10 and 8 tumors were ranked as sensitive to 5FU, paclitaxel, and docetaxel, respectively. IRs of 5FU correlated significantly with those of docetaxel (R=0.37, p=0.0336), but not with those of paclitaxel, suggesting that paclitaxel may be more useful for combined or sequential administration with 5FU. Of the 30 patients, 5 underwent non-curative resection and another 5 had recurrences. Nine of these 10 patients underwent chemotherapy with S-1 (oral tegafur + Gimestat, an inhibitor of dihydroxylpyrimidine dehydrogenase), of which two patients responded, but none had been ranked as sensitive for 5FU. Two of the patients went on to receive weekly paclitaxel as a second line chemotherapy despite not being ranked as sensitive, and were found not to respond. Conclusions: Recommended concentration for HDRA was determined as 10 μg/mL for paclitaxel and 30 μg/mL for docetaxel, respectively. Correlation between the results of HDRA and clinical responses remains unclear. Given that S-1 is the most widely used front line treatment, HDRA should in future be modified to test the effect of 5FU in combination with Gimestat. No significant financial relationships to disclose.
Molecular Mechanisms Of Inhibition Of Ribosomal Biogenesis and Translational Flux By The Selective Inhibitor Of Nuclear Export (SINE) XPO1/CRM1 Antagonist KPT-185 In Mantle Cell Lymphoma
Authors: Yoko Tabe, Kensuke Kojima, Linhua Jin, Hiroko Iwanami, Hiromichi Matsushita, Saiko Kazuno, Tsutomu Fujimura, Takashi Ueno, Takashi Miida, Michael Andreeff
Journal: Blood (2013)
New government, same narrow vision
Authors: H McFarlane, R. Madhok, M G. Nicholls, A M. Richards, P. W Moller, J. M Elliott, E J Begg, A. Padwell
Journal: BMJ (1998)

# How hospitals manage emergency admissions needs to be examined {#article-title-2} EDITOR—Smith was right to suggest that the debate on the NHS should shift to something more important than waiting lists.1 Waiting lists are used by politicians as an indicator of the success or failure of the health service, yet they are merely a measure of how much we as a society wish to spend on the health service. What should be exercising our minds is the ability of hospitals to manage emergency admissions other than those politically important ones occurring over the winter as a result of inclement weather. In 1984 it was recognised that over half of all surgical admissions were emergencies,2 and this has not changed; yet patients admitted as a surgical emergency receive a poor service. At worst they may be operated on at inappropriate times by inappropriate surgeons, although we know this is wrong. Alternatively, they may wait for days for expert opinion or investigation and, when finally scheduled for surgery, find themselves jockeying for position on the emergency theatre list, if such a list exists.3 Hospitals need to examine what happens to emergency patients after admission with as much attention to detail as they currently examine waiting lists. They could find the results worrying, from both a financial and a quality point of view. 1. 1.↵1. Smith R . New government, same narrow vision. BMJ 1998;316: 643. (28 February.) 2. 2.↵1. Jones PF . Night and day. BMJ 1984;289:145-146. 3. 3.↵1. McFarlane H, 2. Krukowski ZH, 3. Youngson GG, 4. Turner M . Theatre usage for emergency surgery—use or abuse. Health Bull 1997;55:32-43. [OpenUrl][1] # Medical profession must change things itself {#article-title-6} EDITOR—Smith's editorial about health policy is timely, but I wonder about relying on the government to ensure good quality care and improve health.1 As Smith points out, globalisation and economic forces limit the government's ability to improve health. The recent … [1]: {openurl}?query=rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx
357O The tumor vascularity and lipiodol deposition predicts risk of disease progression after TACE in patients with unresectable HCC
Authors: C.-S. Chen, F.-K. Li, C.-Y. Guo, J.-C. Xiao, H.-T. Hu, H.-T. Cheng, L. Zheng, D.-W. Zong, J.-L. Ma, L. Jiang, H.-L. Li
Journal: Annals of Oncology (2015)
Increased Melatonin Signaling Is a Risk Factor for Type 2 Diabetes
Authors: Tiinamaija Tuomi, Cecilia L.F. Nagorny, Pratibha Singh, Hedvig Bennet, Qian Yu, Ida Alenkvist, Bo Isomaa, Bjarne Östman, Johan Söderström, Anu-Katriina Pesonen, Silja Martikainen, Katri Räikkönen, Tom Forsén, Liisa Hakaste, Peter Almgren, Petter Storm, Olof Asplund, Liliya Shcherbina, Malin Fex, João Fadista, Anders Tengholm, Nils Wierup, Leif Groop, Hindrik Mulder
Journal: Cell Metabolism (2016)