tbuckley/cabot-search huggingface dataset:
AB1440-HPR The immediate effect of lateral epicondylitis bandage and kinesiotape in patients with lateral epicondylitis: A pilot study
Authors: B. Dilek, G. Gur, Y. Yakut, F. Uygur
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Lateral Epicondylitis or tennis elbow is a frequently encountered clinical entity characterized by pain in the region of the lateral epicondyle of the humerus which is aggravated during resisted dorsiflexion of the wrist. Tendinopathy is the most often mentioned cause and is characterized by a lesion of the common extensor tendon with or without inflammation. Over 40 treatment options are described. Nevertheless, many of these treatments are not supported by strong scientific evidence. <h3>Objectives</h3> To compare the immediate effect of using kinesiotape and lateral epicondylitis bandage on painless, maximal grip and wrist extension strength. <h3>Methods</h3> Ten subjects with an average age of 45±10 years and who had lateral epicondylitis and a duration of pain for 4.30 hours/day were assessed. The assessments were carried out consecutively while not wearing anything, with kinesiotape and with epicondylitis bandage. To avoid carry over effect between kinesiotape and epicondylitis bandage 20 minutes interval was given between applications. Maximal and painless grip and wrist extension strength was measured with Baseline Standard Hydraulic Hand Dynamometer. <h3>Results</h3> Painless grip strength was higher under kinesiotape when compared with not wearing anything and wearing epicondylitis bandage (p&lt;0.05). No difference was found for wrist strength between the three conditions. <h3>Conclusions</h3> The results of this study imply that kinesiotape application can be considered as an option in the treatment of tennis elbow. For more conclusive results, studies with larger numbers of subjects and randomized controlled trials are needed. <h3>References</h3> Struijs PAA, Smidt N, Arola H et al (2001) Orthotic devices for tennis elbow: a systematic review. Br J Gen Pract 51:924-929. Ernest E (1992) Conservative therapy for tennis elbow. Br J Clin Pract 46:55-57. Verhaar JA (1994), Tennis elbow anatomical, epidemiological and therapeutic aspects, Int Orthop, 18, 263-267. Streek VD, Schans VD, Greef D, Postema K (2004), The Effect of a forearm/hand splint compared with an elbow band as a treatment for lateral epicondilitis, Pros and Orth Inter, 28:183-189. Leung HB, Yen CH, Tse PYT (2004), Reliability of Hong Kong Chinese Version of the Patient-rated Forearm Evaluation Questionnaire for lateral epicon: 172-7. <h3>Disclosure of Interest</h3> None Declared
THU0335 Microvascular Findings in Patients with Systemic Lupus Erythematosus - Assessed by Fundus Photography and Fluorescent Angiography
Authors: J. H. Lee, G.-T. Kim, S. S. Kim
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Although a series of trials support systemic lupus erythematosus (SLE) is associated with increased atherosclerosis and cardiovascular events, the link between microvascular structural change and the disease activity of SLE is not defined. <h3>Objectives</h3> We measured retinal microvasculature change by fundus photography and fluorescent angiography (FAG) and investigated the association between retinal vasculature and clinical parameters of SLE. <h3>Methods</h3> Fifty SLE patients and fifty healthy controls were included. Morphometric and quantitative features of the capillary image including retinal vascular sign and vessel diameters were measured with fundus photography and FAG. Information concerning SLE duration, cumulative dose of steroids and/or immunosuppressive drug intake were recorded, and autoantibodies were checked. SLE activity was assessed by SLE disease activity index (SLEDAI). <h3>Results</h3> The mean Central retinal arteriolar equivalent (CRAE) was 89.7 ± 14.5 µm in SLE patients, 123.8 ± 19.9 µm in control, showing narrower arteriole in SLE patients, and were significantly narrower than that of control (p &lt; 0.001). The mean central retinal venular equivalents (CRVE) was 127.7 ± 14.8 µm, and but it reached no statistical significance (144.1 ± 23.1 µm, p = 0.226). Retinopathy was found in 26% of SLE patients. SLE patients with retinopathy were older than those without it, but reached no statistical significance. Disease duration, antidsDNA, and complement levels had no effect on the presence of retinopathy. SLE patients with retinopathy had a tendency to have higher cumulative steroid doses, hsCRP and IgG aCL levels than those without retinopathy. With multiple regression analysis, hsCRP and IgG aCL were identified as contributing factor to the decreased CRAE, whereas no contributing factor was found to CRVE <h3>Conclusions</h3> retinopathy and retinal arteriolar narrowing were more common in SLE patients, and retinal arteriolar diameter had significant correlation with hsCRP and IgG aCL levels. Retinal imaging is a comparative method for the assessment of microvascular findings of SLE patients. <h3>Disclosure of Interest</h3> None Declared
Researchers use crowdfunding site to raise money to test potential paedophilia treatment
Authors: Nigel Hawkes
Journal: BMJ (2016)

Swedish researchers plan to use a UK based “crowdfunding” site to raise money for a trial of a potential treatment for paedophilia.

Christoffer Rahm, a psychiatrist at the Karolinska Institute in Stockholm, has turned to the website Walacea (https://walacea.com) to raise £38 000 (€47 000; $53 500), the balance of the amount he needs to conduct a randomised controlled trial of a testosterone lowering drug in 60 Swedish men. He has already obtained grants for £70 000 from more conventional sources and has recruited the first few volunteers for the trial.

The plan is to use the drug degarelix in a trial whose endpoint will be changes in the risk factors that are believed to contribute to sexual offences: high sexual arousal, disturbed self control, and low empathy. …
SAT0265 Characteristics and Outcomes of Patients with Anca-Associated Vasculitis (AAV) in the Czech Population
Authors: E. Jancova, Z. Hruskova, V. Lanska, J. Svojanovsky, L. Sedova, K. Zamboch, J. Klaboch, M. Kodeda, V. Hanzal, D. Jílek, I. Valkovsky, V. Tesar
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> This study describes characteristics and outcomes of AAV patients included in a nation-wide initiative collecting clinical and laboratory data since 2009. <h3>Methods</h3> Sixteen vasculitis centres (9x Nephrology, 4x Rheumatology, 2x Immunology, 1x Pediatrics) have participated in web-based data collection, consisting of retrospective data supplied at entry and prospective follow-up with a visit recorded every 3-6 months. Statistical analysis included the Kaplan-Meier method and log-rank test for survival analysis. <h3>Results</h3> A total of 681 patients (M/F 326/355, median age at diagnosis 58, range 11-89 years) were enrolled (168pts are newly diagnosed), 338 (50%) c ANCA positive, 236 p ANCA (35%), 24 (4%) ANCA negative and 72 (11%) was not investigated. The mean time from diagnosis was 71 months (range 0-475). GPA was the most common diagnosis with 58%, followed by MPA (including renal-limited form) recorded in 35% and EGPA in 4%. Cumulative organ involvement involved kidney in 83% (confirmed with renal biopsy in 72% of them), lungs in 55% joint 35% and ENT in 34%. Most (88%) pts received cyclophosphamide, azathioprine was used in 60%,mycophenolate mophetil or acid in 24%, methotrexate in 2%, 35% of patients underwent PLEX. To cope with disease activity 35 pts (4%) were treated with biological therapies, most of them (27) by rituximab. At present 512 pts are alive, pts status is assessed as complete remission in 72%, partial remission in 12%, persistent activity in 6%, primo-manifestation - new activity in 3% and relapse in 7%. Most (98%) pts. have hypertension (85% are treated by ACEi), 14 (2%) pts are post kidney Tx, 14% are dependent on dialysis. Last available VDI (Vasculitis Damage Index) ranged between 0 and 16 (median 4). The estimated 5-year survival was 81.5% (95% CI =78.1% - 84.9%) and was significantly higher in patients with ENT involvement compared to those without (p&lt;0.001), but significantly lower in patients with lung involvement compared to those without (p&lt;0.01). Significant differences were found in the estimated survival of patients stratified according to the disease severity at diagnosis (localized &gt; early systemic &gt; generalized &gt; severe renal). <h3>Conclusions</h3> In the Czech population, GPA is the most common AAV, reflecting the northern European type.The disease severity at the diagnosisi is associated with higher mortality. <i>Supported by the Czech Kidney Foundation</i> <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5777
FRI0119 The predictive value of cardiovascular risk factors on carotid intima media thickness in rheumatoid arthritis
Authors: D.F. Van Breukelen-van der Stoep, J. van Zeben, B. Klop, G.-J. M. van de Geijn, N. van der Meulen, T.L. Njo, E. Birnie, M. Castro Cabezas
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is recognized as an independent cardiovascular risk factor. The ongoing inflammatory state in RA is believed to be the main cause of this increased cardiovascular risk since inflammation is a key contributor to atherosclerosis. Carotid intima media thickness (cIMT) is a surrogate marker for (subclinical) atherosclerosis. <h3>Objectives</h3> To identify clinical parameters related to cIMT in patients with RA. <h3>Methods</h3> RA patients &lt;70 years of age without cardiovascular disease (AMI, PTCA, CABG, CVA, TIA, severe claudicatio, PTA and/or amputation due to peripheral arterial disease) and/or diabetes mellitus were included. Patients underwent a standard physical examination including the DAS28. Standard laboratory measurements included a fasting lipid profile. cIMT was measured semi-automatically by ultrasound and skin autofluorescence (SAF) was measured using the AGE Reader<sup>®</sup>. Patients were grouped into tertiles of cIMT. Differences in clinical parameters between the tertiles were tested with ANOVA or chi square. Those parameters with p-ANOVA &lt;0.05 were used in a multivariable linear regression analysis (backward, enter) to identify factors related to cIMT in RA. <h3>Results</h3> A total of 310 patients were included with a mean (±SD) age of 53.3±11.3 years and a median (IQR) RA disease duration of 7.00 (2.00-14.00) years. The median (IQR) DAS28 was 2.2 (1.7-3.0) reflecting low RA disease activity. 212 (68%) patients were female. The mean cIMT was 0.569±0.122 mm. cIMT showed a positive trend in the univariate analyses with RA disease duration, waist circumference, glucose, LDL-C, apolipoprotein B, systolic blood pressure (BP), body mass index, HbA1c, homocystein and SAF. No association between cIMT and RA disease characteristics (i.e. RF, anti-CCP, erosive disease and DAS28) was found. Multiple linear regression analysis without age as a covariate showed a positive association of cIMT with systolic BP (B 0.011 95%CI 0.002-0.19; p=0.02), glucose (B 0.231 95%CI -0.032-0.494.; p=0.09) and SAF (B 0.302 95% CI 0.001.-0.602.; p=0.049) (adjusted R<sup>2</sup>= 0.023). When age was included only age was significantly associated with cIMT (B 0.046 95% CI 0.032-0.060; (p&lt;0.001) (adjusted R<sup>2</sup>=0.450). However, there was a tendency for a contributing effect of systolic BP (B 0.006 95%CI -0.001-0.013; p=0.099). <h3>Conclusions</h3> SAF, systolic BP and glucose were associated with cIMT in RA patients. However, age was the strongest predictor for cIMT in RA, which diminished the association of all other parameters including the classical cardiovascular risk factors, SAF and RA disease duration. In view of the strong effect of age on cIMT, the value of a single measurement of cIMT in RA patients seems limited. <h3>Disclosure of Interest</h3> None Declared
An outbreak of measles in Reims, eastern France, January-March 2008 - a preliminary report
Authors: S Thierry, S Alsibai, I Parent du Châtelet, None on behalf of the investigation team
Journal: Eurosurveillance (2008)

Between the end of January and 12 March 2008, 16 cases of measles were reported to the local health authority in Reims in eastern France. The outbreak has to date affected nine adults and seven children, aged from seven months to 28 years. Among these cases, 13 were biologically confirmed.
DIFFERENTIAL ASSOCIATION OF HIGH-DENSITY LIPOPROTEIN PARTICLE SUBCLASSES AND GLYCA, A NOVEL INFLAMMATORY MARKER, IN PREDICTING CARDIAC DEATH AMONG PATIENTS UNDERGOING ANGIOGRAPHY: THE INTERMOUNTAIN HEART COLLABORATIVE STUDY
Authors: J. Brent Muhlestein, Heidi May, Deborah Winegar, Jeffrey Rollo, Margery Connelly, James Otvos, Jeffrey Anderson
Journal: Journal of the American College of Cardiology (2016)
Abstract 3156: New candidate oncogenes discovered in microsatellite unstable colorectal cancer.
Authors: Alexandra E. Gylfe, Johanna Kondelin, Mikko Turunen, Heikki Ristolainen, Riku Katainen, Esa Pitkänen, Eevi Kaasinen, Ville Rantanen, Tomas Tanskanen, Heli J. Lehtonen, Kimmo Palin, Minna Taipale, Jussi Taipale, Laura Renkonen-Sinisalo, Heikki Järvinen, Jan Böhm, Jukka-Pekka Mecklin, Ari Ristimäki, Sari Tuupanen, Auli Karhu, Outi Kilpivaara, Pia Vahteristo, Lauri A. Aaltonen
Journal: Cancer Research (2013)

Abstract Around 15% of colorectal cancers (CRCs) show microsatellite instability (MSI). A characteristic high passenger mutation load has discouraged systematic mutation screens in MSI CRCs. To systematically search for novel MSI CRC oncogenes, the exomes of 25 MSI CRC-normal pairs were sequenced as the discovery set. Observed hot spots were confirmed by Sanger sequencing and further validated in a set of 86 MSI CRCs. Mutational hot spots were confirmed in 15 genes and three genes showed additional hot spot mutations in the validation set. These three sites were highly conserved across species. The hot spot sites of these three genes were screened in 75 microsatellite stable CRCs and 12 MSI CRC cell lines with negative results. Next, we analyzed the subcellular localization of wild-type and mutant proteins. The findings of this study support the idea that cancer genomes are heterogeneous and characterized by few, frequently mutated “mountains” (e.g. BRAF and KRAS) and numerous, less frequently mutated “hills”. The identified mutational hot spots may prove important in developing personalized tumor profiling and therapy. Citation Format: Alexandra E. Gylfe, Johanna Kondelin, Mikko Turunen, Heikki Ristolainen, Riku Katainen, Esa Pitkänen, Eevi Kaasinen, Ville Rantanen, Tomas Tanskanen, Heli J. Lehtonen, Kimmo Palin, Minna Taipale, Jussi Taipale, Laura Renkonen-Sinisalo, Heikki Järvinen, Jan Böhm, Jukka-Pekka Mecklin, Ari Ristimäki, Sari Tuupanen, Auli Karhu, Outi Kilpivaara, Pia Vahteristo, Lauri A. Aaltonen. New candidate oncogenes discovered in microsatellite unstable colorectal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3156. doi:10.1158/1538-7445.AM2013-3156
Utility of F-18 FDG PET/CT in Screening for Paraneoplastic Neurological Syndromes
Authors: Akiyuki Matsuhisa, Akira Toriihara, Kazunori Kubota, Tomoko Makino, Hidehiro Mizusawa, Hitoshi Shibuya
Journal: Clinical Nuclear Medicine (2011)

The aim of this study was to assess the utility of positron emission tomography/computed tomography (PET/CT) for the investigation of patients with suspected paraneoplastic neurologic syndrome (PNS).We reviewed the whole-body fluorodeoxyglucose (FDG) PET/CT studies (ordered by the neurology department) performed at our hospital between December 2005 and November 2010; 27 cases (16 men, 11 women; mean age, 65 years) who were suspected of having PNS were selected.Of the 27 patients, 6 (22%) had an abnormal FDG uptake. Of these 6 patients, 5 (19%) were histologically confirmed as having a malignancy. Of the 27 patients, 7 were tested for the presence of well-characterized paraneoplastic antibodies (anti-Hu, anti-Ri, anti-Yo); 1 had anti-Hu, but the patient did not have an abnormal FDG uptake or malignancy.PET/CT may be a useful screening tool for patients with clinically suspected PNS who do not exhibit well-characterized paraneoplastic antibodies. Therefore, we recommended that PET/CT should be performed for patients with clinically suspicious PNS regardless of the presence of well-characterized paraneoplastic antibodies.
Effectiveness of Trauma-Focused Cognitive Behavioral Therapy for Children and Adolescents: A Randomized Controlled Trial in Eight German Mental Health Clinics
Authors: Lutz Goldbeck, Rainer Muche, Cedric Sachser, Dunja Tutus, Rita Rosner
Journal: Psychotherapy and Psychosomatics (2016)

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Trauma-focused cognitive behavioral therapy (Tf-CBT) is efficacious for children and adolescents with posttraumatic stress symptoms (PTSS). Its effectiveness in clinical practice has still to be investigated. &lt;b&gt;&lt;i&gt;Aims:&lt;/i&gt;&lt;/b&gt; To determine whether Tf-CBT is superior to waiting list (WL), and to investigate the predictors of treatment response. &lt;b&gt;&lt;i&gt;Method:&lt;/i&gt;&lt;/b&gt; We conducted a single-blind parallel-group randomized controlled trial in eight German outpatient clinics with the main inclusion criteria of age 7-17 years, symptom score ≥35 on the Clinician-Administered PTSD Scale for Children and Adolescents (CAPS-CA), and caregiver participation. Patients were randomly assigned to 12 sessions of Tf-CBT (n = 76) or a WL (n = 83). The primary outcome was the CAPS-CA symptom score assessed at 4 months by blinded evaluators. The secondary measures were diagnostic status, the Children's Global Assessment Scale (CGAS), self-reported and caregiver-reported PTSS (UCLA-PTSD Reaction Index), the Child Posttraumatic Cognitions Inventory (CPTCI), the Children's Depression Inventory (CDI), the Screen for Child Anxiety- Related Emotional Disorders (SCARED), the Child Behavior Checklist (CBCL/4-18), and the Quality of Life Inventory for Children. &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Intention-to-treat analyses showed that Tf-CBT was significantly superior to WL on the CAPS-CA (Tf-CBT: baseline = 58.51 ± 17.41; 4 months = 32.16 ± 26.02; WL: baseline = 57.39 ± 16.05; 4 months = 43.29 ± 25.2; F&lt;sub&gt;1, 157&lt;/sub&gt; = 12.3; p = 0.001; d = 0.50), in terms of secondary measures of the CGAS, UCLA-PTSD-RI, CPTCI, CDI, SCARED, and CBCL/4-18, but not in terms of quality of life. Age and comorbidity significantly predicted treatment response. &lt;b&gt;&lt;i&gt;Conclusions:&lt;/i&gt;&lt;/b&gt; Tf-CBT is effective for children and adolescents with heterogeneous trauma types in German service settings. Younger patients with fewer comorbid disorders show most improvement.
Abstract 3737: The PI3K/mTOR inhibitor PWT33597 regresses 786-0 renal xenografts
Authors: Marie O'Farrell, Richard Ventura, Albert Tai, David J. Matthews
Journal: Cancer Research (2012)

Abstract PWT33597 is a balanced dual inhibitor of phosphatidylinositol 3-kinase alpha (PI3K alpha) and mTOR, currently in clinical development. Inhibition of signaling downstream of PI3K and mTOR by PWT33597 has been demonstrated, and PWT33597 is strongly efficacious in multiple xenograft models tested to date with different PIK3CA and PTEN genotypes. Inhibitors of mTORC1 (rapalogs) are approved for treatment of advanced renal cell carcinoma (RCC), but their effect is restricted to a subset of patients, and is not sustained. Inhibitors of VEGFR signaling such as sorafenib and sunitinib have also demonstrated clinical activity in RCC and are approved in this indication. Based on the proven role of rapalogs in RCC, we tested PWT33597 in a renal xenograft model with the hypothesis that inhibition of both mTORC1 and mTORC2, as well as PI3K, may offer increased efficacy by direct targeting of multiple signaling nodes including VEGFR signaling. Dual inhibition would also be expected to decrease release of negative feedback loops triggered by either mTOR or PI3K inhibition alone. PWT33597 was tested in 786-0 (VHL -/-, PTEN -/-) xenografts in comparison to rapamycin (mTORC1 inhibitor), and sorafenib (VEGFR/RAF inhibitor). While sorafenib and rapamycin showed tumor growth inhibition (TGI), the maximal effect with sorafenib was 64% TGI, and rapamycin had a largely cytostatic effect. The overall efficacy observed with PWT33597 was superior, with 93% TGI observed. PWT33597 was also tested in comparison to a pan-PI3K inhibitor (GDC-0941, 49% TGI) and demonstrated superior efficacy. Immunohistochemical analysis of tumors for cleaved caspase 3 (CC3) as an indicator of apoptosis showed that a single dose of PWT33597 induced a several fold increase in CC3 staining, and this effect was also apparent after 18 days of dosing. Based on these results we tested the ability of PWT33597 to regress large 786-0 tumors (approx. 500 mm3), and a rapid decrease in tumor size was observed in 100% of animals. Additional cellular and xenograft studies in RCC models are ongoing to further define the mechanism of action of PWT33597, and will be presented. Taken together, these data provide rationale for testing PWT33597 in patients with RCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3737. doi:1538-7445.AM2012-3737
Case 25-1999
Authors: John B. Watkins, Fiona M. Graeme-Cook, Jonathan Samuels
Journal: New England Journal of Medicine (1999)

Presentation of CaseA 16-year-old boy presented to the hospital as an outpatient because of recurrent abdominal pain.The patient had been well until the age of four years, when he began to have two or three bouts annually of mild, crampy abdominal pain that lasted from a few hours to a day and were occasionally accompanied by fever. At the age of 14 years, he had a more severe bout of pain, followed by several days of profuse vomiting and dehydration. He was admitted to another hospital, where abdominal radiographs showed dilated loops of small bowel with air–fluid levels. . . .
Runx1 is essential at two stages of early murine B-cell development
Authors: Birte Niebuhr, Neele Kriebitzsch, Meike Fischer, Kira Behrens, Thomas Günther, Malik Alawi, Ulla Bergholz, Ursula Müller, Susanne Roscher, Marion Ziegler, Frank Buchholz, Adam Grundhoff, Carol Stocking
Journal: Blood (2013)
Interstitial pneumonia with autoimmune features: the new consensus-based definition for this cohort of patients should be broadened
Authors: Aryeh Fischer, Harold R. Collard, Vincent Cottin
Journal: European Respiratory Journal (2016)

We appreciate the careful reading and concerns expressed by Drs. Collins and Raghu regarding our recently published European Respiratory Society/American Thoracic Society Research Statement on "interstitial pneumonia with autoimmune features" (IPAF). Critical assessment of this document and concept is essential to improving our understanding of this novel classification. We clarify that patients with UIP can indeed be classified as interstitial pneumonia with autoimmune features (IPAF) <http://ow.ly/YGKLl>