tbuckley/cabot-search huggingface dataset:
Abstract 1213: Cytotoxic T lymphocyte antigen-2 alpha (CTLA-2α) induces apoptosis in lymphoma cells and is regulated by the cAMP/PKA signaling pathway
Authors: Lingzhi Zhang, Xia Hwang, Paul A. Insel
Journal: Cancer Research (2010)

Abstract The second messenger cAMP promotes apoptosis of lymphoma and leukemia cells but mechanisms that mediate this apoptosis are poorly understood. We thus used wild-type (WT) murine S49 T lymphoma cells and S49 variants that lack PKA and cAMP-promoted responses (kin-) or have normal PKA activity but lack cAMP-promoted-apoptosis (“Deathless”, D-) to examine such mechanisms. Results from DNA microarrays revealed that the largest increase in gene expression induced by 8-CPT-cAMP treatment of WT cells is that of cytotoxic T lymphocyte antigen (CTLA-2α), an inhibitor of cathepsin L-like cysteine proteinases. By contrast, CTLA-2α expression was not increased in kin- S49 cells and only slightly increased in D- S49 cells treated with 8-CPT-cAMP. Real-time PCR and immunoblotting confirmed the prominent cAMP-promoted increase in CTLA-2α expression in WT cells. The β-adrenergic receptor agonist isoproterenol and the adenylyl cyclase activator forskolin also induced CTLA-2α gene expression in WT cells, thus indicating that increased CTLA-2α expression can occur via activation of endogenous activators of the cAMP/PKA signaling pathway. Treatment with an adenoviral construct, Adv-CTLA-2α, induced apoptosis in both WT and D- S49 cells but enhanced cAMP-promoted apoptosis only in WT cells. WT, but not D-, S49 cells treated with 8-CPT-cAMP had increased cathepsin activity. Taken together, these results indicate that the cAMP/PKA pathway up-regulates CTLA-2α expression and based on the contrasting findings obtained with WT vs. D- S49 cells, CTLA-2α may be a key contributor to cAMP/PKA-promoted apoptosis. CTLA-2α and cysteine proteases thus appear to have previously unappreciated roles in apoptosis of lymphoid cells by agents that increase cellular cAMP levels. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1213.
Endoscopic submucosal dissection in a rare case of carcinoma cuniculatum of the esophagus initially misdiagnosed as benign squamous papilloma
Authors: Roxana Coman, Amy Collinsworth, Peter Draganov
Journal: Endoscopy (2014)

A 65-year-old woman presented for evaluation of a large esophageal mass, diagnosed on biopsy as squamous cell papilloma. Computed tomography (CT) showed no lymphadenopathy or distant metastases. The patient refused surgery. Endoscopic mucosal resection (EMR) was attempted at a tertiary referral center but could not be carried out because of difficulty in lifting the lesion. Thus, she was referred to our center for endoscopic submucosal dissection (ESD).
More and Stiffer Mammography Clinic Regulations On the Way
Authors: C. Nelson
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article More and Stiffer Mammography Clinic Regulations On the Way Get access Corinna Nelson Corinna Nelson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 22, 16 November 1994, Pages 1673–1674, https://doi.org/10.1093/jnci/86.22.1673 Published: 16 November 1994
Abstract 1354: Chronic social stress in a mouse model of triple-negative breast cancer is associated with oncogenic changes in mammary fat.
Authors: Paul A. Volden, Erin Wonder, Maxwell Skor, Feenalie Patel, Martha McClintock, Matthew Brady, Suzanne Conzen
Journal: Cancer Research (2013)

Abstract Chronic social isolation is linked to increased mammary tumor growth in rodent models of breast cancer. In the C3(1)/SV40 T-antigen (Tag) FVB/N mouse model of “triple-negative” breast cancer, the heightened stress response elicited by social isolation has been associated with increased expression of metabolic genes in the mammary gland before invasive tumors develop (i.e. during the in situ carcinoma stage). To further understand how underlying accelerated mammary tumor growth is associated with social isolation, we separated the mammary gland adipose tissue from adjacent ductal epithelial cells and analyzed individual cell types for changes in metabolic gene expression. Specifically, increased expression of the key metabolic genes Acaca, Hk2 and Acly was found primarily in the adipocyte, rather than epithelial fraction. Increased metabolic gene expression in the mammary adipocytes of socially isolated mice coincided with increased glucose metabolism, lipid synthesis, and leptin expression. Furthermore, culture media from isolated mouse mammary adipose tissue resulted in relatively increased proliferation and decreased apoptosis of mammary epithelial cancer cells derived from the same mouse strain. Additional gene expression analyses identified significant upregulation of the novel carbohydrate response element binding protein beta isoform (CHREBP-β) in socially isolated mammary fat. We hypothesize that the response to social isolation induces metabolic changes in mammary fat that are coordinated through CHREBP-β and are pro-oncogenic. We are currently performing global lipidomic and metabolomic analyses of mammary adipose tissue and secreted culture media to identify bioactive molecules involved in tumor growth. Citation Format: Paul A. Volden, Erin Wonder, Maxwell Skor, Feenalie Patel, Martha McClintock, Matthew Brady, Suzanne Conzen. Chronic social stress in a mouse model of triple-negative breast cancer is associated with oncogenic changes in mammary fat. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1354. doi:10.1158/1538-7445.AM2013-1354
895 HEPATITIS C VIRUS SPECIFIC T LYMPHOCYTES RESPONSE INDUCED BY DENDRITIC CELL LOADED WITH NOVEL IDENTIFIED HLA-A2 RESTRICTED HEPATITIS C VIRUS EPITOPE PEPTIDES
Authors: Z. Guo, H. Zhang, H. Rao, D. Jiang, X. Cong, J. Wang, L. Wei
Journal: Journal of Hepatology (2012)
AB0729 Correlative analysis of handy rheumatoid activity score, with 38 joints (hras38) and musculoskeletal ultrasound for rheumatoid arthritis.
Authors: K. Misaki, T. Nakazawa, H. Yamada, S. Fujita, T. Yokota
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The disease activity score 28 (DAS28), clinical disease activity index (CDAI) and simplified disease activity index (SDAI) are all used in the clinical assessment of rheumatoid arthritis (RA). A consensus concerning the appropriate assessment method of swollen joints has yet to be reached and standardized grading criteria are yet to be created. <h3>Objectives</h3> For our study we selected HRAS38 due to the recent attention it has gathered and performed a correlative analysis between HRAS38 &lt;1&gt; assessment and musculoskeletal ultrasound by semi-quantitative grading assessment (MSKUS) for the purpose of evaluation. <h3>Methods</h3> One hundred and eighty patients who satisfied either the 1987 American College of Rheumatology (ACR) or 2010 ACR/European League Against Rheumatism (EULAR) rheumatoid arthritis (RA) criteria were enrolled in this study (mean age: 62.8±14.4 years, mean DAS28-C-reactive protein (CRP): 3.06±1.43, female: 123 cases, male: 57 cases, respectively). Ten joints of the left hand (metacarpophalangeal [MCP] 1-5 joints and proximal interphalangeal [PIP] 1-5 joints) were validated both with HRAS38 and MSKUS semi-quantitative grading. The 38 joints included in the evaluation were 26 joints of DAS28 except for bilateral shoulder joints, as well as 10 metatarsophalangeal (MTP) joints and the bilateral ankle joints. Each joint was scored as follows: 0 = none; 1 = mild (not convincing by observation and confirmed by palpation); 2 = moderate (convincing by observation, but not tense); 3 = severe (tense). The MSKUS estimation was divided into gray scale (GS) (grade 0-3) and power Doppler examination (PD) (grade 0-3). The agreement between HRAS38 and MSKUS (GS and PD) was calculated using Cohen’s Kappa values. <h3>Results</h3> The median Kappa Value for GS examination was 0.221 and for PD examination was 0.268, respectively. Fairagreement was observed for GS of the PIP4 (Kappa =0.505) and PD of the MCP3 (Kappa=0.420), respectively. For the total patients who scored 0 for HRA38, indicating no swollen joints, positive GS was observed in 35% of patients (387 joints/1107 joints) and PD was observed in 15.9% of patients (205 joints/1289 joints). <h3>Conclusions</h3> According to our correlative analysis, agreement was fair between HRAS38 and MSKUS. Furthermore, analysis suggested that MSKUS is more significant in the assessment of RA, with swollen joints which were not revealed according to HRAS38 being revealed as active synovitis by MSKUS. The authors recommend that MSKUS is used as the principal method of RA assessment. <h3>References</h3> Mod Rheumatol (2006) 16:381–388 <h3>Disclosure of Interest</h3> None Declared
Stretcher's Scrotum
Authors: Mark W. Ragozzino
Journal: New England Journal of Medicine (1993)

To the Editor: A 40-year-old recreational athlete recovering from a low back injury had acute scrotal swelling and pain several hours after performing stretching exercises for the lower back. There was no history of acute scrotal trauma during the previous week. The symptoms and swelling gradually subsided over a period of several days. Magnetic resonance imaging two weeks after the onset of symptoms demonstrated a subacute scrotal hematoma measuring 3 cm by 1 cm by 1 cm. Reenactment of the stretching routine demonstrated compression of the testes when one knee was brought to the chest and restrictive gym shorts were . . .
Abstract 3431: Role of tumor microenvironment in promoting tumor metastasis
Authors: Arti Yadav, Bhavna Kumar, Theodoros N. Teknos, Pawan Kumar
Journal: Cancer Research (2010)

Abstract Metastatic spread of tumor cells to vital organs is the major cause of mortality in cancer patients. Tumor metastasis is a complex process involving multiple steps including detachment of tumor cells from the primary tumor, interaction with vascular endothelium and invasion of target organs. Although our understanding of the molecular and biological events that contribute to tumor cell progression has increased considerably over the last decade, we still know very little about the role of tumor-accessory cells in promoting tumor cell release from the primary tumor and metastasis to distal sites. It is well established that tumor angiogenesis plays a critical role in tumor progression. We have recently demonstrated that VEGF, in addition to its pro-angiogenic function, also induces the expression of Bcl-2 in the microvascular endothelial cells. Furthermore, tumor samples from head and neck cancer patients showed significantly higher Bcl-2 expression in tumor blood vessels and this enhanced Bcl-2 expression in tumor-associated endothelial cells was directly correlated with metastatic status of these patients. Upregulated Bcl-2 expression in tumor-associated endothelial cells was sufficient to enhance tumor metastasis of oral squamous cell carcinoma in a SCID mouse model. While much is known about the role of Bcl-2 in cell survival, very little is known about the role of Bcl-2 in tumor metastasis. In this study, we examined the role and mechanism(s) by which Bcl-2 expression in tumor-associated endothelial cells may promote tumor metastasis. Our results suggest that endothelial cells expressing Bcl-2 (EC-Bcl-2) promote tumor metastasis via cell-cell interaction with tumor cells as well as by secreting chemokines including IL-6 and IL-8. EC-Bcl-2 secreted IL-6 induced EMT-related changes (downregulation of E-cadherin and upregulation of vimentin proteins) in the normal oral keratinocytes as well as head and neck tumor cells. IL-8 promoted tumor metastasis by enhancing tumor cell motility and invasiveness. In addition, EC-Bcl-2 cells exhibited significantly higher adhesion molecules expression and showed enhanced tumor cell binding. Tumor cells, when cultured alone in non-adherent conditions, showed marked increase in apoptosis (anoikis). In contrast, tumor cells showed a significant decrease in anoikis when co-cultured with EC-Bcl-2 in non-adherent conditions. Similarly, tumor cells when injected along with EC-Bcl-2 showed significantly higher lung metastasis as compared to tumor cell and EC-VC or tumor cell alone group. Taken together, these results suggest that endothelial cells expressing Bcl-2 promote tumor cell metastasis by enhancing tumor cell release and chaperoning them to distal sites. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3431.
Postherpetic Neuralgia — Pathogenesis, Treatment, and Prevention
Authors: Rhonda G. Kost, Stephen E. Straus
Journal: New England Journal of Medicine (1996)

Spontaneous pain, pain provoked by trivial stimuli, and altered sensation accompany herpes zoster and may continue long after its characteristic rash has healed — a condition known as postherpetic neuralgia. Many approaches have been proposed to treat the pain of acute zoster, to avert its progression to postherpetic neuralgia, and to alleviate postherpetic neuralgia. Few of these approaches have been proved beneficial, and postherpetic neuralgia remains a source of frustration for both patients and physicians. In this article, we summarize current knowledge of the pathogenesis of postherpetic neuralgia and developments in its treatment and prevention.Clinical DiseaseHerpes zoster typically . . .
ESFINTEROPLASTIA COMO COMPLEMENTO A LA ESFINTEROTOMÍA ENDOSCÓPICA EN LA EXTRACCIÓN DE LITIASIS DE GRAN TAMAÑO EN LA ANCIANIDAD
Authors: B Merino Rodríguez, C González Asanza, Ó Nogales Rincón, C Carbonell, A Caballero, E Hernández, G Perez Rial, L Ibañez, K Klimova, F Díaz Fontenla, P Menchén Fernández Pacheco
Journal: Endoscopy (2013)

Introducción: La extracción de litiasis mediante CPRE es un reto técnico cuando las dimensiones de la litiasis exceden el tamaño de la esfinterotomía endoscópica. Estas litiasis son comunes en la ancianidad, población con mayor riesgo de complicaciones. Objetivo: Evaluar la eficacia y seguridad de la esfinteroplastia tras esfinterotomía en litiasis de difícil extracción en la ancianidad. Material y Método: Estudio retrospectivo en pacientes mayores de 65 años con litiasis > 1 cm en la vía biliar extrahepática que no pudieron ser extraídas con balón/cesta tras esfinterotomía endoscópica. La esfinteroplastia fue llevada a cabo usando un balón estándar de 12 a 20 mm. Se valoró el éxito técnico y las complicaciones asociadas. Resultados: 154 pacientes (71 hombres, 83 mujeres) cumplieron los criterios de inclusión en el periodo entre enero 2008 a marzo de 2013. La edad media fue de 79 años (rango de 65 – 93). El tamaño medio de las litiasis fue 16 mm (rango 12 a 20 mm). Las litiasis fueron extraídas con esfinteroplastia en la primera sesión en 148/154 (96.1%) de los pacientes, 6/154 (3,9%) pacientes en un segundo intento. Seis pacientes (3,9%) requirieron litotricia mecánica adyuvante. Se recomendó cirugía en 4 (2,6%) de los pacientes debido a la imposibilidad de extracción endoscópica. El éxito global fue del 93,5% Complicaciones en 24 pacientes (16,2%): Sangrado en 5 (3,3%) controlado con inyección de adrenalina en 2 pacientes y los demás de forma conservadora. Pancreatitis aguda en 15 pacientes (9,7%). Ninguna grave. 2 perforaciones (1.3%), con buena evolución con tratamiento conservador. Ningún paciente falleció. Conclusiones: Técnica eficaz para la extracción de litiasis de gran tamaño. Evita la litotricia mecánica o cirugía en la mayoría de los pacientes. Es un procedimiento seguro pero el número de complicaciones en la ancianidad son mayores de los descritos en la población general.
Endoscopic Pancreatic Sphincterotomy: Dual Sphincterotomy vs. Endoscopic Pancreatic Sphincterotomy Alone
Authors: S. S. Lee, M.-H. Kim, S.-K. Lee, C. Y. Hwang
Journal: Endoscopy (2003)

We read with interest the article by Jakobs et al. concerning endoscopic pancreatic sphincterotomy (EPS) in patients with chronic pancreatitis [1]. They concluded that EPS in patients with chronic pancreatitis is a fairly safe procedure, with a high rate of technical success. We agree that EPS is a safe procedure for chronic pancreatitis. However, we have some questions on EPS technique.
ANATOMICAL AND PROCEDURAL DETERMINANTS OF CATHETER-BASED RENAL DENERVATION
Authors: Sebastian Ewen, Christian Ukena, Thomas Luscher, Martin Bergmann, Peter Blankestijn, Bodo Cremers, Erwin Blessing, Oliver Doerr, Holger Nef, Markus Schlaich, Faisal Sharif, Michiel Voskuil, Thomas Zeller, Abraham R. Tzafriri, Elazer Edelman, Michael Boehm, Felix Mahfoud
Journal: Journal of the American College of Cardiology (2016)
Double papilla of Vater: a rare anatomic variant
Authors: Dimitrios Katsarelias, Mohammed Faisal, Robert Glavas, Wolf Bartholomä
Journal: Endoscopy (2016)

A 68-year-old man who had undergone a cholecystectomy in the 1980s was admitted acutely with right upper quadrant pain. He was treated conservatively and an ultrasound scan showed mild common bile duct (CBD) dilatation and one stone. A magnetic resonance cholangiopancreatography (MRCP) scan was subsequently performed, which visualized a 9-mm stone in the CBD. After discussion with the patient, it was decided to perform an elective endoscopic retrograde cholangiopancreatography (ERCP).
Management of Sickle Cell Disease
Authors: M H Steinberg
Journal: New England Journal of Medicine (1999)

One of every 600 black people in the United States has sickle cell anemia. In addition, sickle cell–hemoglobin C disease and sickle cell–β-thalassemia, which are other common genotypes of sickle cell disease, together are as common as sickle cell anemia. Sickle hemoglobin (hemoglobin S, α2 β2S) accounts for over half the hemoglobin in patients with these disorders. Eight percent of black Americans are heterozygous carriers of the sickle cell trait; about 40 percent of their hemoglobin is hemoglobin S. They do not have anemia and need neither treatment nor occupational restrictions. About 5 percent have hematuria at . . .
A Snapshot of Oregon's Cancer Coverage
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article A Snapshot of Oregon's Cancer Coverage Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 14, 15 July 1992, Page 1065, https://doi.org/10.1093/jnci/84.14.1065 Published: 15 July 1992
AB1055 Renal function and treatment of gouty arthritis in primary care
Authors: E. Mikhnevich
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Renal dysfunction is common in gout and occurs due to various combinations of hyperuricemia, comorbidities (hypertension, atherosclerosis, diabetes), and medication (NSAIDs, allopurinol). In these conditions, the medication should be safe for kidneys. However, primary care general practitioners (GP) tend to prescribe high doses of NSAIDs in gouty arthritis that could lead to renal insufficiency, especially in case of a relatively long term treatment. <h3>Objectives</h3> To assess treatment of gouty arthritis administrated by GP and to determine changes in the renal function. <h3>Methods</h3> 100 patients enrolled with acute gouty arthritis fulfilled ACR 1977 classification criteria for acute gouty arthritis. 83% of patients were males with the mean age of 57,5 years and average disease duration of 8,8 years. Comorbidities included hypertension (77%), ischemic disease (7%), chronic cardiac failure (15%), diabetes (21%), and renal calculi (33%). 33 patients received Allopurinol 100-300 mg/day and 3 patients received 600 mg/day. Patients were given a short half-life NSAIDs prescribed by GP. Preferred NSAID was Diclophenac taken by 61% of patients at a daily dose of 175 mg or 200 mg. An average duration of treatment in primary care was 17 days. The treatment goal was not achieved, and the patients were admitted to the Rheumatology Unit. Changes in GFRs and also the factors decreasing renal function were studied during the follow-up. <h3>Results</h3> Maximal doses of NSAIDs were prescribed to 97 patients including 15 patients with GFRs &lt;60 ml/min. 47 patients continued the same dosing within the treatment period. After NSAIDs treatment, 47% of patients had increased GFRs (86,8 vs 102,6, ml/min, p&gt;0,05), the number of patients with GFRs &lt;90 ml/min diminished from 28 to 19 (p=0,063). 53% of patients had decreased GFRs (95,8 vs 78,1 ml/min, p&lt;0,05), the number of patients with GFRs less than 90 ml/min raised from 27 patients at the beginning of treatment to 39 patients after NSAIDs treatment (p=0,016). The number of patients taking high doses of NSAIDs during the treatment period was higher in the group with negative changes in GFRs (OR-2,73; 95%CI, 1,73 to 4,32; p=0,015). Comparing various features of these groups, we found that cases of infection making 20,8% (pneumonia 1, bronchitis 2, pyelonephritis 3, suppurrated tophis 5) (OR-9,75, 95%CI, 1,3-72,96; p=0,012) and symptoms of nhronic heart failure (OR-4,88; 95%CI 1,13 to 21; p=0,038) probably due to NSAIDs were more frequent in group with reduced GFRs. <h3>Conclusions</h3> In primary care, NSAIDs are preferred drugs for treating acute gouty arthritis. They are even prescribed in pre-existing renal insufficiency. The results of the study suggest that renal function during acute gout attack can improve or worsen. High doses of NSAIDs can produce a negative effect on renal function during the treatment period because of concomitant infections and chronic heart failure. <h3>Disclosure of Interest</h3> None Declared