tbuckley/cabot-search huggingface dataset:
AB0850 Prevalence of Musculoskeletal Disorders in Firefighters and Its Association with Insomnia
Authors: M. Abbasi, Z. Yazdi, M.M. Mahdavifar
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Musculoskeletal disorders (MSDs) are among the main underlying reasons for decreased productivity at workplace. Awkward working posture, forceful movements, and unexpected events are main reasons for high prevalence of MSDs in firefighters. According to previous research, there is a significant contribution between MSDs and other co-morbidities such as insomnia. <h3>Objectives</h3> The present study aimed to evaluate the prevalence of MSDs in firefighters and its relation with severity of insomnia. <h3>Methods</h3> A cross sectional study was conducted on firefighters in Qazvin. Demographic information was collected for the participants. A self-administered questionnaire including Nordic question, body map, and insomnia severity index were completed by the firefighters. Descriptive statistics, student t-test, and Chi-square were used for data analysis. <h3>Results</h3> Prevalence of MSDs was 54.2% amongst the firefighters, and low back pain was the most common complaint with 30.5%. The highest intensity of pain was in the middle of lumbar region. 20.3% of firefighters had subclinical insomnia, and 30% of them had moderate to severe insomnia. Severity of insomnia was significantly more in subjects with MSDs (12.4±7.9) compared to those without MSDs (7.1±6.6) (P&lt;0.05). Among different parts of body, significant association was solely found between back pain and severity of insomnia. <h3>Conclusions</h3> The results showed that MSDs, especially around the lumbar region is associated with the severity of insomnia in firefighters. In addition, the prevalence of MSDs and insomnia was significantly higher in firefighters compared to similar studies in general population which calls for preventive activities. <h3>References</h3> Crofford LJ. Psychological aspects of chronic musculoskeletal pain. Best Practice &amp; Research Clinical Rheumatology. 2015. Ahmadi f, abolsamadi h, roshanaei g, jaliliyan s. The prevalence of musculoskeletal disorders in General dentists in Hamadan. Hamadan University of Medical Sciences. 2012;19(3):61–6. <h3>Acknowledgement</h3> The authors thanks all firefighters participated in this study. <h3>Disclosure of Interest</h3> None declared
PTU-132 Autonomic Function Scores and Sleep Disturbance Scores in FGID Patients with and Without Upper Limb Temperature Dissociation
Authors: KJ Etherson, C Emmett, Y Yiannakou
Journal: Gut (2016)

<h3>Introduction</h3> Background Central autonomic dysfunction may result in a unilateral dissociation of temperature sensation, and is increasingly being investigated in FGIDs. The autonomic function score (AFS) and sleep disturbance score (SDS) are accepted measures in aiding the diagnosis of autonomic dysfunction. <h3>Aims</h3> To assess and compare the AFS and SDS of consecutive FGID patients attending a specialist clinic, with and without upper limb temperature dissociation. <h3>Methods</h3> Clinic attenders with a FGID diagnosis were sequentially invited to undertake the temperature sensation test. This comprised holding a bag of ice in both hands for 30 seconds and stating if they perceived the temperature to be either unilaterally colder or bilaterally equally cold. Unilaterally colder was considered to be evidence of upper limb temperature sensory dissociation. Patients had their total AFS calculated as follows: headaches, dizziness, sweating and sleep disturbance were severity scored using a Likert scale of 0–3, the sum of which is the AFS. The mean total AFS and mean sleep disturbance score were compared between patients with and without temperature dissociation. <h3>Results</h3> 173 patients completed the AFS and 7 were excluded from the analysis for incomplete data leaving 166. 115 patients (69%) had upper limb temperature dissociation (group 1) compared to 51 (31%) with normal temperature sensation bilaterally (group 2). The mean total AFS in group 1 was 6.35 [SD 3.17] compared with 5.01 [SD 2.87] in group 2 [P = 0.009]. Mean sleep disturbance scores were not significantly different between the groups. <h3>Conclusion</h3> FGID patients with upper limb temperature dissociation appear to have a significantly higher autonomic function score than those without temperature dissociation. This seems to suggest that the cause of the temperature dissociation may well be due to autonomic dysfunction acting at a central nervous system level. These results are an interesting observation from our clinic but are likely to be limited by inherent methodological biases in the data collection. Further investigation of autonomic function scores and temperature dissociation are required in formal and appropriately powered clinical research studies to validate these findings. <h3>Disclosure of Interest</h3> None Declared
A Selective and Potent Oral Inhibitor of the JAK2 Tyrosine Kinase Reverses Polycythemia and Leukocytosis Induced by JAK2 V617F in a Mouse Model.
Authors: Virginia M. Zaleskas, Wayne W. Chan, Peter Evangelista, Katherine Lazarides, Rajesh Chopra, Michael Zinda, Dennis Huszar, Richard A. Van Etten
Journal: Blood (2007)
PWE-048 Small Intestinal Bacterial Overgrowth is Increased in Gastric Bypass, Small Bowel Resection and Short Bowel Syndrome
Authors: A El-Habishi, J McLaughlin, W Johns, E Leitao, P Paine
Journal: Gut (2016)

<h3>Introduction</h3> Small intestinal bacterial overgrowth (SIBO) testing is confounded by transit time, which can be increased in a number of surgical conditions. This study aims to evaluate whether patients who have undergone a gastric bypass, small bowel resection or who have been diagnosed with short bowel syndrome have a higher prevalence of SIBO than patients who have not, and whether they respond to antibiotic treatment <h3>Methods</h3> In total, 520 adult patients (360 female, 160 male, mean age 49) who underwent hydrogen and glycocholate-methane breath tests for a suspicion of SIBO between the dates 01/01/2010 and 31/12/2013 were evaluated. Their clinical information including their test results, working diagnosis, management and outcomes of management were recorded. <h3>Results</h3> 84 patients had undergone a gastric bypass (31), small bowel resection (27) or had been diagnosed with short bowel syndrome (26). 40 of these patients tested positive in both hydrogen and glycocholate-methane breath tests (48.2%). 437 patients with normal anatomy were also tested over the same period, of which 61 tested positive (14.0%). (48.2% vs 14.0%, Chi-square statistic = 50.8911, p = 0). 34 patients who had undergone a gastric bypass, small bowel resection or had been diagnosed with short bowel syndrome who tested positive were treated with antibiotics. 28 (82.4%) benefitted from this. 56 patients who tested positive in the other group were given antibiotics, 41 (73.2%) of whom benefitted from this. <h3>Conclusion</h3> Patients who had undergone a gastric bypass, small bowel resection or have been diagnosed with short bowel syndrome have a much higher rate of positive SIBO test results compared to patients who have not, and have a similar response rate to antibiotic therapy. This suggests these post-surgical patients have a higher incidence of true SIBO than those with normal anatomy and benefit from antibiotics. This implies these are true positive cases and not false positives due to shortened transit times. Future studies controlling for transit would help clarify these findings further. <h3>Disclosure of Interest</h3> None Declared
AB0875 Analysis of Joint Function in Children with Juvenile Idiopathic Arthritis against The Background of Standard Therapy
Authors: M.A. Abiodun, E.A. Adegoke, N. Panko, N. Shevchenko
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is a chronic and socially significant disease as it leads to quick disability in childhood despite treatment <h3>Objectives</h3> To study the development of joint dysfunction in patients with JIA against the background of standard therapy with methotrexate <h3>Methods</h3> The study involved 83 children within 2–18 years with JIA: oligoarthritis in 39,6%, polyarticular form – 37,7%, systemic form – 20,8%, enthesitis-related arthritis – 1,9%. Changes in the joints were assessed depending on the duration of disease: 1–2 years (25 patients), 3–5 years (23 patients), 5–10 years (35 patients). There were 51 females, 33 males. Criteria of decreased function of joints include: amplitude of motion of hands less then 110°; elbows, knees, ankles and wrists – less then 50°, shoulder and hip joints - less than 70°. For the statistic processing of the material, Stagraphics 3.0 was used. <h3>Results</h3> With an increase in the duration of the disease despite standard care, the joint tenderness according to Ritchie index and joint pain according to <i>Visual Analogue Scale</i> were decreased, especially after 5 years of illness (p&lt;0,0 5). The most significant signs of joint determination were limitation of motion and function of articular apparatus. It was found that frequency limited to function of joints among our patients was 77.11%, which was a prerequisite of patients9 disability. With an increase in duration of disease, frequency of limited function of joints constantly grew and probably greater in comparison with the initial stages of the disease (p&lt;0.05). The most common joints, which lost motion, were knee, radio-wrist, ankle and hip. In stages over three years of course of JIA, limited motion were found in all of the affected joints. Cervical spine lesion was determined in 33.3% of patients typically after 2 years of duration of JIA. In term from one to two years despite treatment in 50% of patients, affection of hip joints were presented. It was determined during the first two years, the changes that correspond to 0 (27,3%) and I stage of the disease by Steinbrocker (72,7%), from 3 year in 45,5% of children II stage was found, from 4th year 15,4% - III, after 6th year 14,7% persons had IV stage. The main stage of deterioration of the radiological changes is the term disease for more than 5 years, when significantly the frequency of the III stage in comparison with the previous period is increased (p&lt;0,01) and the IV stage is appeared. <h3>Conclusions</h3> It reflected steadily progressive destructive changes of the musculoskeletal system with limited motion of joints function despite therapy with methotrexate and independent of activity of disease and symptom load. <h3>Disclosure of Interest</h3> None declared
Anti-NK Cell Treatment Induces Stable Mixed Chimerism in MHC-Mismatched, T-Cell Depleted, Nonmyeloablative Bone Marrow Transplantation.
Authors: Seok Goo Cho, Yukinobu Shuto, Yasushi Soda, Yukoh Nakazaki, Kyoko Izawa, Kaoru Uchimaru, Satoshi Takahashi, Kenzaburo Tani, Arinobu Tojo, Shigetaka Asano
Journal: Blood (2004)
The Predictive Role of Germinal Center or Non-Germinal Center Phenotypes in Diffuse Large B-Cell Lymphoma Patients Receiving CHOP or R-CHOP
Authors: Sun-ah Lee, Hun-Mo Ryoo, Sung Hwa Bae, Hyun Young Jung, Saet Byul Jang, Yoon Seop Keum
Journal: Blood (2008)
FRI0530 Intra-and Inter-Observer Reliability of Nailfold Videocapillaroscopy – A Possible Outcome Measure for Systemic Sclerosis-Related Microangiopathy?: Table 1
Authors: G. Dinsdale, T. Moore, N. O'Leary, J. Manning, A. Murray, M. Berks, P. Tresadern, J. Allen, M. Anderson, M. Cutolo, R. Hesselstrand, K. Howell, C. Pizzorni, P. Pyrkotsch, V. Smith, A. Sulli, M. Wildt, C. Taylor, C. Roberts, A. Herrick
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Nailfold videocapillaroscopy (NVC) has been proposed as an outcome measure for systemic sclerosis [SSc] related microvascular disease. <h3>Objectives</h3> To assess the reliability of both measure availability and measured value of 4 parameters extracted from NVC images: capillary density, capillary (apex) width, overall image grade (normal, early, active, late), and the presence of giant capillaries. <h3>Methods</h3> 173 subjects were recruited in the study (101 with SSc, 22 with primary Raynaud9s phenomenon and 50 controls). Panoramic NVC imaging was performed on all 10 digits using a 300x magnification microscope with green LED illumination for best capillary contrast. Ten capillaroscopy experts (“raters”) from 7 centres assessed images using custom software. Raters were asked to: (1) assess overall image grade (“Normal”, “Early”, “Active”, “Late”, “Non-specific”, or “Ungradeable”), (2) mark the location of capillary apices (capillary density calculated from distal vessel locations), (3) categorically grade the distal vessels in terms of size and shape, and (4) measure the apical width of distal vessels using a click-and-drag tool. <h3>Results</h3> The 10 raters analysed a median (range) of 129 (98–1641) images, returning 3401 evaluations of 1650 images, including a sub-sample analysed twice by the same rater to measure intra-rater reliability. Of these, 2731 evaluations (80%) satisfied the criteria to allow vessel density to be measured (at least 2 distal vessels identified). The reliability (intra- and inter-rater) of both measure availability and measured value for the 4 parameters are shown in the table. Overall image grade was available in only around 45% of observations due to the exclusion of “non-specific” gradings from the analysis. <h3>Conclusions</h3> Capillary density and (especially) apical width, parameters likely to be helpful in quantifying temporal change, were reliable measures in evaluable nailbeds. The reliability of measured values is generally high, but is conditional on measure availability. This must be accounted for when considering the applicability of outcome measures to clinical trial situations. With standardised training (and potentially increased automation of analysis), high magnification NVC has strong potential as an outcome measure of SSc-related microangiopathy. <h3>Acknowledgement</h3> Work funded by the Raynaud9s &amp; Scleroderma Association. <h3>Disclosure of Interest</h3> None declared
Mobilisation with G-CSF in Helathy Donors Promotes a High but Temporal Deregulation of Genes.
Authors: C. Castilla, N. C. Gutierrez, I. M. Isidro, M. Delgado, J. Rivas, E. Ferminan, M. C. Canizo, J. M. Hernandez, J.F. San Miguel
Journal: Blood (2004)
SAT0334 Nationwide Trends in Hospitalization and in-Hospital Mortality Associated with Anca-Associated Vasculitis (AAV)
Authors: Z. Wallace, L. Lu, E. Miloslavsky, S. Unizony, J. Stone, H. Choi
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> ANCA-associated vasculitis (AAV) is associated with severe end-organ damage (e.g., renal failure) and treatment-related complications (e.g., severe infection) which often lead to hospitalization. However, no data on recent hospitalization trends and associated mortality are available<sup>1</sup>. <h3>Objectives</h3> We evaluated recent trends in nationwide hospitalization, cost, and in-hospital mortality among patients with AAV. <h3>Methods</h3> We used the National Inpatient Survey (NIS) which is the largest all-payer inpatient database in the US. We studied all hospitalizations with a discharge diagnosis of AAV (ICD 9: 446.4) between 1993 and 2011. We investigated trends in hospitalization, cost, and mortality by comparing AAV to overall inpatient hospitalization trends. Analyses were performed using hospital-level sampling weights provided by the NIS to obtain US national estimates. <h3>Results</h3> From 1993 to 2011, the rate of hospitalization for AAV increased from 1.9/100,000 persons to 4.5/100,000 persons (P-for-trend &lt;0.0001). This was primarily driven by a rapid increase in the hospitalization rate among those with a secondary discharge diagnosis of AAV (1.4/100,000 persons to 3.9/100,000 persons, P&lt;0.0001). Over the study period, there was a significant decline in in-hospital death from 9.9% (±1.2%) in 1993 to 3.5% (±0.4%) in 2011 (P-for-trend &lt;0.0001). Overall, the annual relative change in AAV mortality was - 4.8% (95% CI: -5.6 to -4.0%). This was a significantly greater decline than overall US inpatient hospitalization mortality (-2.18%, 95% CI -2.19% to -2.17%). Infection was the most common principal diagnosis when AAV was a secondary diagnosis. <h3>Conclusions</h3> Between 1993 and 2011, there was a significant decline in in-hospital mortality among those admitted with a diagnosis of AAV. This decline was significantly greater than that of the overall US in-hospital mortality rate. The declining in-hospital mortality rate may be due to earlier recognition of GPA, shifts in treatment that emphasize less cyclophosphamide use and more tempered use of glucocorticoids, and secular trends in the management of infections and end-organ complications<sup>2</sup>. <h3>References</h3> Cotch MF, Hoffman GS, Yerg DE, Kaufman GI, Targonski P, Kaslow RA. The epidemiology of wegener9s granulomatosis. estimates of the five-year period prevalence, annual mortality, and geographic disease distribution from population-based data sources. Arthritis Rheum. 1996;39(1):87–92. Wallace ZS, Lu N, Unizony S, Stone JH, Choi HK. Improved survival in granulomatosis with polyangiitis: A general population-based study. Semin Arthritis Rheum. 2015. <h3>Disclosure of Interest</h3> None declared
SAT0605 Towards A Taxonomy That Is Science-Based and Clinically Useful: The New Who - ICD11 Classification of Musculoskeletal Pain Disorders
Authors: S. Perrot, M. Cohen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The current ICD 10 classification of musculoskeletal pain disorders is not relevant, combining anatomical, pathophysiological and clinical approaches. In 2015, the WHO started a new program for ICD11 classification, to be delivered in 2017. In this new program, physicians and researchers from rheumatology and pain clinics have been involved for the musculoskeletal pain chapter that will be developed in collaboration with the IASP/ International Association for the Study of Pain. <h3>Objectives</h3> To develop a taxonomy for musculoskeletal (MSK) pain conditions that merge insights from both pain pathophysiology and rheumatological clinical classification for both clinical and scientific uses. <h3>Methods</h3> As members of the IASP-WHO Task Force for the Classification of Chronic Pain in ICD-11, the authors have reviewed the taxonomy of musculoskeletal conditions in ICD-10 and earlier iterations and conventional taxonomy in rheumatology, all of which are disease-based and commonly do not reflect the problems encountered in the practice of pain medicine. The authors have pragmatically integrated recent advances in musculoskeletal pain pathophysiology into diagnostic labelling in this diverse field as a prelude to a multiaxial approach. <h3>Results</h3> Two sets of taxonomic reforms will be presented. The first conforms to the format required by ICD which remains anatomically or disease based. This comprises four main categories: chronic musculoskeletal pain from persistent inflammation; chronic musculoskeletal pain associated with structural changes; chronic musculoskeletal pain due to disease of the nervous system; and chronic primary musculoskeletal pain (to include spinal pain and widespread pain). The second prefers classification by pain mechanisms and identifies conditions characterized by nociceptive pain and primary hyperalgesia and those characterized by nociplastic* pain and secondary hyperalgesia. <h3>Conclusions</h3> The authors contend that the somatic dimension of musculoskeletal pain conditions is better conceptualized by incorporating underlying pain pathophysiology in conventional disease labels rather than by describing MSK pain as different disease entities or as “pain syndromes”. These proposed new taxonomic sets are not mutually exclusive and can probably be integrated for clinical purposes, not only in pain clinics but also in rheumatology settings. Although they refer to the somatic or biomedical dimension of the complex experience of musculoskeletal pain, they can be readily integrated with the psychological and social axes of evolving taxonomy. <h3>Disclosure of Interest</h3> None declared
Long-Term Safety of Sustained Eculizumab Treatment in Patients with Paroxysmal Nocturnal Hemoglobinuria
Authors: Jeffrey Szer, Petra Muus, Alexander Roeth, M.O Elebute, Antonio M. Risitano, Hubert Schrezenmeier, Jaroslaw P. Maciejewski, Alvaro Urbano-Ispizua, Carlos Manuel de Castro, Gérard Socié, Robert A. Brodsky
Journal: Blood (2012)
PTU-084 Decompensated Cirrhosis in the Acute Medical Unit – A Neglected Group?
Authors: Y Gao-Du, G Abouda, L Corless
Journal: Gut (2016)

<h3>Introduction</h3> Decompensated chronic liver disease (DCLD) is a medical emergency with high mortality, usually managed by non-specialists in emergency (ED) and acute medical (AMU) departments in critical early stages. A recently introduced BSG/BASL care bundle<sup>1</sup> (CB) highlights crucial investigations, which can influence outcome if performed early (&lt;6 hr). We audited performance against CB recommendations and impact on outcome. <h3>Methods</h3> Data was reviewed retrospectively using electronic records. Adherence to 4 key CB investigations (blood tests/cultures, ultrasound (US) and ascitic tap in &lt;6 hr) was logged, plus arrival/admission time and outcome (length of stay – LOS; readmission rate, mortality). <h3>Results</h3> All patients admitted over 3 months with DCLD were included (n = 25 patients/33 total AMU admissions). Ascites (51.5%) and jaundice (24.2%) were the commonest presenting complaints. Most (57.6%) had Childs C disease (Childs A 6%; B 36.4%). LOS was variable (mean 11 days; median 7 [1–60]), and 7 people were readmitted within 1 month. In-patient mortality was 16% (12.1% of admissions) in keeping with national data, and 80% were alive at 3 months. No-one had all 4 investigations performed within 6 hr of admission. 81.8% had routine blood tests performed (usually by ED), but only 15.1% had blood cultures, despite early identification of sepsis being a critical aspect of DCLD care. All cultures were taken for other reasons (e.g. cellulitis, pyrexia/rigour) suggesting sepsis risk in DCLD is under-appreciated by non-specialists. 39.4% had US requested within 6 hr and there was a lack of awareness of hepatoma/venous thrombosis as DCLD precipitants. Just 24.1% of those with ascites had a diagnostic tap within 6 hr, with most not performed until under gastroenterology care. Data suggests this was due to inexperience of the admitting doctor, both in understanding importance of excluding/treating sepsis early, and technical capability to perform the test. Slow patient flow added considerable delay to assessment/investigation, with 35% arriving in AMU &gt; 6 hr post ED arrival (mean 4.5; median 5.5 [0.3–16 hr]), closing the window of opportunity for early intervention. There was a non-significant trend towards long waits in those who subsequently died (mean 7.5 hr; median 5.9 [3.6–14.5]), but no correlation between delay and LOS. <h3>Conclusion</h3> Patients with DCLD were under-investigated and experienced considerable delay in assessment and investigation, possibly impacting mortality. CB awareness was limited, and we identified failure of non-specialists to appreciate causes of DCLD and importance of rapid and robust assessment, compounded by delays in patient flow. We arranged talks for AMU staff on DCLD, and have commenced enhanced gastroenterology in-reach for ED/AMU, to identify and treat patients more rapidly. <h3>Reference</h3> 1 http://www.bsg.org.uk/images/stories/docs/decomp_cirrhosis_care_bundle.doc <h3>Disclosure of Interest</h3> None Declared
The Combination of Azacitidine (AZA) and Recombinant Erythropoietin (rEPO) Can Induce Rapidly Hematological Response In Intermediate-2 and High-risk MDS (including RAEB-t)
Authors: Haris Kartsios, Kostas Loukidis, Vassilios Papadopoulos, Smaragda Effraimidou, Anastasia Spyrou, Kyriaki Kokoviadou, Emmanouil Papadakis, Anna Kioumi, Ioannis Korantzis
Journal: Blood (2010)