tbuckley/cabot-search huggingface dataset:
Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis
Authors: Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane Broye, Jeff Wyckoff, Joelle Klazen, John Lamar, Sreeja Asokan, Charlie Whittaker, Robert Langer, Michael Cima, Kari Wisinski, Richard Hynes, Douglas Lauffenburger, Patricia Keely, James Bear, Frank Gertler
Journal: Cancer Research (2016)

Abstract The tissue microenvironment, composed of stromal cells and extracellular matrix (ECM), is known to contribute to tumor progression, by providing both the structure and signals that promote tumor cell proliferation, survival and invasion. Fibronectin and collagen are major components of the tumor microenvironment, however, how tumor cells gain the ability to respond to these substrate-bound cues and how ECM sensing contributes to promoting metastasis remain poorly understood. Here, using a combination of in vitro and in vivo imaging, we show that gradients of FN can promote directional cell motility of breast cancer cells, a process dependent upon the actin regulatory Mena. Expression of the pro-metastatic isoform MenaINV allows cells to haptotax towards very high concentrations of FN, found near blood vessels and tumor periphery. Haptotaxis requires the direct interaction between α5β1 integrin and Mena/ MenaINV and is driven by outside-in signaling at focal complexes, crosstalk between α5β1 and EGFR, and inside-out tumor cell dependent ECM remodeling. These findings are clinically relevant as patients with high levels of MenaINV protein and FN have increased recurrence and decreased survival in two breast cancer cohorts. Our results identify a novel tumor cell-intrinsic mechanism that promotes ECM remodeling and directed migration, ultimately affecting metastasis. Citation Format: Madeleine J. Oudin, Oliver Jonas, Tatiana Kosciuk, Liliane Broye, Jeff Wyckoff, Joelle Klazen, John Lamar, Sreeja Asokan, Charlie Whittaker, Robert Langer, Michael Cima, Kari Wisinski, Richard Hynes, Douglas Lauffenburger, Patricia Keely, James Bear, Frank Gertler. Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr PR15.
Branched Polyethylenimine-Superparamagnetic Iron Oxide Nanoparticles (bPEI-SPIONs) Improve Immunogenicity of Myeloma Tumor Antigen to Enhance Th1 Polarization of Dendritic Cells
Authors: My-Dung Hoang, Hwa-Jeong Lee, Hyun-Ju Lee, Sung-Hoon Jung, Nu-Ri Choi, Manh-Cuong Vo, Thanh-Nhan Nguyen-Pham, In-Kyu Park, Hyeoung-Joon Kim, Je-Jung Lee
Journal: Blood (2014)
Central Role of LIC-R2 (Ferriscan®) Determination in Patients with Hemoglobinopathies: Licnet Experience
Authors: Giuseppina Calvaruso, Angela Vitrano, Francesco Gioia, Filippo Cassarà, Saveria Campisi, Franco Butera, Valeria Commendatore, Michele Rizzo, Vincenzo Santoro, Pamela Murgano, Valeria Cigna, Alessandra Quota, Sabrina Bagnato, Crocetta Argento, Carmelo Fidone, Dario Schembari, Calogera Geradi, Filippo Barbiera, Giuseppe Bellisiima, Roberto Giugno, Gesualdo Polizzi, Rosamaria Rosso, Giovanna Abbate, Vincenzo Caruso, Elisabetta Chiodi, Maria Rita Gamberini, Benedetta Giorgi, Maria Caterina Putti, Aldo Filosa, Laura Mistretta, Massimiliano Sacco, Aurelio Maggio
Journal: Blood (2014)
Chlorimipramine therapy for obsessive-compulsive neurosis
Authors: J Ananth, L Solyom, S Bryntwick, U Krishnappa
Journal: American Journal of Psychiatry (1979)

Twenty patients with a history of treatment-resistant obsessional neurosis underwent a 4-week clinical trial of chlorimipramine. Scores on the Psychiatric Questionnaire for Obsessive Compulsive Neurosis, the Leyton Obsessional Inventory, and 3 self-assessments indicated that although there was no significant change in obsessive ruminations, obsessive rituals, horrific temptations, or pervading doubt, there was a substantial significant improvement in the obsessive symptom item and severity of obsessions, as well as anxiety, depression, and phobia. Side effects were mild. The authors believe that chlorimipramine is the most promising treatment for obsessive-compulsive neurosis.
Vertebral Osteomyelitis
Authors: Werner Zimmerli
Journal: New England Journal of Medicine (2010)

A 57-year-old man presents 2 weeks after prostate biopsy with fever, chills, and new lumbar back pain. His temperature is 39.7°C; he has an enlarged, tender prostate and lumbar spine tenderness. His white-cell count is 9100 per cubic millimeter, and the C-reactive protein level is 343 mg per liter. Urine and blood cultures reveal multidrug-resistant extended-spectrum β-lactamase–producing Escherichia coli susceptible to imipenem. How should he be evaluated and treated?
Analysis of Failures and Complications of Neodymium: YAG Laser Photocoagulation in Gastrointestinal Tract Tumors
Authors: E M Mathus-Vliegen, G N Tytgat
Journal: Endoscopy (1990)

Eight years of experience with endoscopic Nd:YAG laser photocoagulation were analyzed in retrospect in an attempt to identify factors relating to both failures and complications of laser therapy, and to delineate its limits and pitfalls in benign and malignant tumors. Three hundred and seventy-eight patients were studied, including 42 with gastroesophageal cancer, 180 with colorectal adenoma and 156 with colorectal malignancy. Patients with gastroesophageal cancer (n = 42) were referred mainly for obstruction in esophageal cancer and for bleeding in gastric cancer, with successful palliation in 86 and 81%. Hemorrhage was the only complication seen, twice during and twice after treatment. Pain, heat and smoke-induced complaints and sometimes temporary increased dysphagia were mentioned. Two white-surfaced tumors did not react at all. Patients with colorectal adenoma (n = 150) were divided into groups according to the size of the lesion. Definitive, histologically documented eradication of adenomatous tissue was achieved in 43% of the extensive, in 69% of the intermediate, and in 97% of the small adenomas. Major complications, mainly stenosis and hemorrhage, occurred in 6.4%, 7.6% and none of the lesions, respectively, and minor complications were seen in 57.4, 30.8 and 13.8%, respectively. Stenosis appeared to be related only to prior electrocoagulation and to excessive delivery of energy. Post-treatment hemorrhage occurred at about day 7. In familial polyposis (n = 30) surveillance of the rectal stump was successful in 84%, with major and minor complications in 4% and 12%. In colorectal cancers (n = 156) treated for palliation of bleeding and obstruction, success was obtained in 91%. major complications (13%) consisted mainly of stenosis and perforation.(ABSTRACT TRUNCATED AT 250 WORDS)
The Influence of Thymectomy on the Incidence of Carcinogen-Induced Leukemia in Strain DBA Mice
Authors: L W LAW, J H MILLER
Journal: JNCI Journal of the National Cancer Institute (1950)

The Influence of Thymectomy on the Incidence of Carcinogen-Induced Leukemia in Strain DBA Mice Get access L. W. Law, L. W. Law Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. Miller J. H. Miller National Cancer Institute, National Institutes of Health, U. S. Publc Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 2, October 1950, Pages 425–437, https://doi.org/10.1093/jnci/11.2.425 Published: 01 October 1950 Article history Received: 22 August 1950 Published: 01 October 1950
The Metabolism of Melanomas in Platyfish-Swordtail Hybrids
Authors: Douglas G. Humm, Eloise E. Clark
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article The Metabolism of Melanomas in Platyfish-Swordtail Hybrids Get access Douglas G. Humm, Douglas G. Humm Department of Zoology, University of North Carolina, Chapel Hill, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar Eloise E. Clark Eloise E. Clark Department of Zoology, University of North Carolina, Chapel Hill, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 3, December 1955, Pages 741–761, https://doi.org/10.1093/jnci/16.3.741 Published: 01 December 1955 Article history Received: 09 May 1955 Published: 01 December 1955
Abstract P3-09-04: Growth inhibitory effects of Cornus officinalis on a model for triple negative breast cancer
Authors: NT Telang, HB Nair, GYC Wong
Journal: Cancer Research (2016)

Abstract Background: The triple negative breast cancer (TNBC) molecular subtype is characterized by the absence of estrogen receptor-α (ER-α), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) expressions. TNBC is refractory to endocrine and to HER-2 selective therapy, while options for the treatment of choice involving high dose Anthracyclin/Taxol based conventional chemotherapy and/or small molecule inhibitor based targeted therapy are associated with systemic toxicity and acquired tumor resistance, leading to compromised efficacy. These limitations emphasize a need to identify efficacious non-toxic agents for secondary prevention/therapy of TNBC. Cornus officinalis (CO) is a Chinese herb of a nutritional nature in the form of a fruit. It is a major ingredient herb in some well-known Chinese herbal formulations for health management purposes. Growth inhibitory efficacy of CO in a model for ER positive Luminal A molecular subtype of clinical breast cancer is associated with abrogation of estradiol promoted growth via generation of anti-proliferative estradiol metabolites [Telang et al: Mol. Med. Rep. 5: 20-28, 2012].The present study examines the growth inhibitory effects of CO, and identifies possible molecular targets for its efficacy in a pre-clinical cell culture model for TNBC. Experimental model, Herbal Extract and Biomarkers: The human mammary carcinoma-derived ER-α negative, PR negative and HER-2 negative MDA-MB-231 cell line represents the model for TNBC. Non-fractionated aqueous extract from CO represents the test agent. Anchorage dependent growth, anchorage independent (AI) colony formation, cell cycle progression, cellular apoptosis and relevant pathway specific mechanistic assays represent the biomarkers for efficacy. Results: Treatment of MDA-MB-231 cells with CO extract induces substantial dose dependent cytostatic growth arrest (IC50:0.1%; IC90:0.5%), and strongly inhibits AI colony formation. Within the cytostatic range CO inhibits G1 to S phase transition leading to G1 arrest that is accompanied by decreased expressions of Cyclin D1 and p-RB. Cellular apoptosis induced by CO is associated with modulation of the BAX-BCL-2 pathway, and up-regulation of the pro-apoptotic Caspase 3/7 activity. Conclusions: These data provide a mechanistic evidence for efficacy of CO as a naturally occurring nutritional substance in a cell culture model for TNBC. The present study validates a mechanism based approach to prioritize efficacious non-toxic herbal extracts for secondary prevention/therapy of the TNBC molecular subtype of clinical breast cancer. Citation Format: Telang NT, Nair HB, Wong GYC. Growth inhibitory effects of Cornus officinalis on a model for triple negative breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-09-04.
Reminiscences: 1938 and since
Authors: J Romano
Journal: American Journal of Psychiatry (1994)

The author cites significant changes in the conduct of the psychiatric profession between the fourth and ninth decades of this century. Determinants of the changes included the impact of World War II, the National Mental Health Act of 1946, the evolution of multiple modes of psychotherapy, the move from a system of involuntary incarceration and treatment in public institutions to a voluntaristic and pluralistic system, the provision of public and private insurance support for office, outpatient, and inpatient psychiatric care, the resurgence of psychopharmacology, and the pursuit of research in biological and psychosocial fields. The social goals of the profession are also discussed.
Myocardial Infarction Patterns in Young Subjects with Normal Coronary Arteriograms
Authors: WILLIAM LIKOFF, BERNARD SEGAL, LEONARD DREIFUS
Journal: Circulation (1962)

For the present, the primary obligations of this communication are to acknowledge that the electrocardiographic patterns of myocardial ischemia, injury, and necrosis may appear in asymptomatic, young white males who have low-intensity systolic murmurs; to record that any implication that these electrical deviations result from obstructive coronary disease cannot be substantiated by coronary arteriography; and to suggest that individuals possessing these diagnostic features may represent a distant, recognizable clinical entity the etiology of which remains obscure.
On Teachers
Authors: Richard M. Ratzan
Journal: New England Journal of Medicine (1982)

I often muse about great teachers and history. I wonder, for example, about smallpox and Parkinson's disease, and about what would have happened if one of John Hunter's assistants, instead of the master himself, had performed the pedagogic chore (as it is looked on nowadays) of teaching Edward Jenner or James Parkinson. Would the inspiration that these two men received have been the same? Probably not. If they had known beforehand that they would see Hunter rarely if ever outside his laboratory, would they still have come? Again, probably not. For students flocked from far and wide to Hunter's side, . . .
Soundings: Student feedback
Authors: James Owen Drife
Journal: BMJ (2000)

The medics' revue is a tradition that does not stand still. Compared with our own efforts as students, today's shows have more sophisticated backing tracks, more gender equality, and much more bumping and grinding (all of it from the male members of the cast). The comparison is memory based, however, not evidence based. Ours was a pre-video generation—something that causes me mingled regret and relief.

Today's performers seem so confident, with their synchronised dance routines involving all four limbs and their benign responses to heckling colleagues. The targets hardly change but the satire can still be original. This year an offstage voice announced a preclinical lecture: a Chinese student stood gravely at a lectern and spoke in fluent Cantonese, with the occasional insertion of “immunology . . . T cell . . . cytokine . . .”

As a senior member of staff you enjoy the obvious jokes, like the dean's face on the sun rising above the Meditubbies, but you sense that others are passing you by. Young teachers whom you regard as rather trendy are lampooned because their clothes are out of fashion. You smile uneasily.

But it goes deeper than dress sense. The students are cool. The Ali G lookalike appeared last year but not this year. The humour is post-ironic and post-stereotyping: “Aren't you from Ethiopia?” “No, I'm from Sri Lanka. It's just that I've shaved my head.” What on earth must these knowing undergraduates think of our clumsy attempts to teach them correct attitudes?

For the staff, the revue provides better feedback than a sackful of questionnaires. This comes less from the scripts than from audience reaction, as some remarks are greeted with a roar of the laughter of recognition. It tells you a lot about other people's teaching styles, though the most spectacular response is when female students name a would-be Don Juan.

An annual jab of disrespect should be compulsory for everyone, particularly those of us whom overconfidence could otherwise lead into danger. The BMA would benefit—but who would put on the show?

I left happy, and not just because I had been sung about by a bowtie-bedecked chorus. There is something life affirming about people putting heart and soul into doing a thing well. And about a virtuoso trumpeter. As Ali G might say, it gives you hope for da future and dat's good, man, innit?
Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer
Authors: Arti Hurria, Supriya Mohile, Ajeet Gajra, Heidi Klepin, Hyman Muss, Andrew Chapman, Tao Feng, David Smith, Can-Lan Sun, Nienke De Glas, Harvey Jay Cohen, Vani Katheria, Caroline Doan, Laura Zavala, Abrahm Levi, Chie Akiba, William P. Tew
Journal: Journal of Clinical Oncology (2016)

Purpose Older adults are at increased risk for chemotherapy toxicity, and standard oncology assessment measures cannot identify those at risk. A predictive model for chemotherapy toxicity was developed (N = 500) that consisted of geriatric assessment questions and other clinical variables. This study aims to externally validate this model in an independent cohort (N = 250). Patients and Methods Patients age ≥ 65 years with a solid tumor, fluent in English, and who were scheduled to receive a new chemotherapy regimen were recruited from eight institutions. Risk of chemotherapy toxicity was calculated (low, medium, or high risk) on the basis of the prediction model before the start of chemotherapy. Chemotherapy-related toxicity was captured (grade 3 [hospitalization indicated], grade 4 [life threatening], and grade 5 [treatment-related death]). Validation of the prediction model was performed by calculating the area under the receiver-operating characteristic curve. Results The study sample (N = 250) had a mean age of 73 years (range, 65 to 94 [standard deviation, 5.8]). More than one half of patients (58%) experienced grade ≥ 3 toxicity. Risk of toxicity increased with increasing risk score (36.7% low, 62.4% medium, 70.2% high risk; P &lt; .001). The area under the curve of the receiver-operating characteristic curve was 0.65 (95% CI, 0.58 to 0.71), which was not statistically different from the development cohort (0.72; 95% CI, 0.68 to 0.77; P = .09). There was no association between Karnofsky Performance Status and chemotherapy toxicity (P = .25). Conclusion This study externally validated a chemotherapy toxicity predictive model for older adults with cancer. This predictive model should be considered when discussing the risks and benefits of chemotherapy with older adults.
Abstract B10: Overexpression of the lncRNA PVT1 contributes to the cervical cancer phenotype, possibly via association with nucleolin
Authors: Marissa Iden, Samantha Fye, Keguo Li, Tamjid Chowdhury, Ramani Ramchandran, Janet S. Rader
Journal: Cancer Research (2016)

Abstract The plasmacytoma variant translocation 1 gene (PVT1) is an lncRNA that has been designated as an oncogene due to its contribution to the phenotype of multiple cancers. Although the mechanism by which PVT1 influences disease processes has been studied in multiple cancer types, its role in cervical tumorigenesis remains unknown. Thus, the present study was designed to investigate the role of PVT1 in cervical cancer in vitro and in vivo. PVT1 expression was measured by quantitative PCR (qPCR) in 121 invasive cervical carcinoma (ICC) samples, 19 normal cervix samples, and a cervical cell line (SiHa). Further, we used targeted knockdown in conjunction with functional assays to examine PVT1's effects on cervical cancer cell proliferation, migration and invasion, apoptosis, and cisplatin resistance. Our results demonstrate that PVT1 expression is significantly increased in ICC tissue versus normal cervix. PVT1 knockdown in cervical cancer cell lines resulted in significantly decreased cell proliferation, migration and invasion. Further, apoptosis and cisplatin cytotoxicity were significantly increased in PVT1 siRNA-transfected cells. Finally, we show that PVT1 associates with Nucleolin protein and may aid in its stabilization of GADD45A mRNA providing a possible mechanism by which PVT1 overexpression drives cervical carcinogenesis. Citation Format: Marissa Iden, Samantha Fye, Keguo Li, Tamjid Chowdhury, Ramani Ramchandran, Janet S. Rader. Overexpression of the lncRNA PVT1 contributes to the cervical cancer phenotype, possibly via association with nucleolin. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr B10.
Effect of denosumab versus zoledronic acid in patients with castrate-resistant prostate cancer and bone metastases: Subgroup analyses by prior SRE and baseline pain.
Authors: N. D. Shore, M. R. Smith, M. Jievaltas, K. Fizazi, R. Damião, J. Chin, K. Miller, J. P. Maroto, Y. Qian, A. Feng, K. Chung, C. D. Goessl
Journal: Journal of Clinical Oncology (2011)

4533 Background: Bone metastases from castrate-resistant prostate cancer (CRPC) are associated with osteoclast-mediated bone destruction and skeletal-related events (SREs). Denosumab is a fully human monoclonal antibody against RANKL, a key mediator of osteoclast formation, function, and survival. Previous results from a phase III trial showed denosumab was superior to zoledronic acid (ZA) in delaying or preventing SREs (pathologic fracture, radiation or surgery to bone, or spinal cord compression) in patients with bone metastases from CRPC. This analysis assesses the effect of denosumab vs ZA treatment among patients with earlier stage CRPC - those with no prior SRE or no/mild pain at baseline. Methods: Patients with CRPC and ≥1 bone metastasis and no prior IV bisphosphonate use were randomized to receive either SC denosumab 120 mg + IV placebo or SC placebo + IV ZA 4 mg (adjusted for creatinine clearance) every 4 weeks. Patients also were instructed to take calcium and vitamin D supplements. Time to 1st on-study SRE (primary endpoint) and time to 1st and subsequent SRE (multiple event analysis) were evaluated in patients with no prior SRE or no/mild pain. The Brief Pain Inventory – Short Form (BPI) was used to assess worst pain scores at baseline. A score of 0 to 4 on the BPI indicates no or mild pain. Results: Of the 1901 patients enrolled (n = 950 denosumab; n = 951 ZA), 1438 were in the subgroup of patients with no prior SRE and 1045 were in the subgroup with no/mild pain (BPI score 0 to 4) at baseline. As compared with ZA, denosumab treatment significantly delayed the time to 1st SRE for the overall population (HR = 0.82 [0.71, 0.95]; P = 0.008), as well as in both subgroups of patients with earlier disease: no prior SRE (HR = 0.80 [0.67, 0.95]; P = 0.011) or no/mild pain at baseline (HR = 0.77 [0.63, 0.95]; P = 0.014). Similar results also were noted with denosumab vs ZA treatment for the time to 1st and subsequent SREs (P ≤ 0.007 for all groups). Conclusions: Denosumab treatment in patients with earlier stage CRPC significantly reduced SREs.
THE BACTERIOLOGY OF BRONCHITIS.
Authors: J MULDER
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal