tbuckley/cabot-search huggingface dataset:
AB0601 How do Gps Manage GIANT Cell Arteritis (GCA): A Primary Care Survey
Authors: T. Helliwell
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Giant cell arteritis (GCA) although the commonest large vessel vasculitis, is relatively uncommon in primary care. However, given the potentially serious complications of GCA including visual loss, general practitioners (GPs) need to recognise suspected GCA early and instigate appropriate management. UK BSR guidelines advocate early referral for specialist review and the initiation of treatment with high dose corticosteroids to minimise the likelihood of visual loss [1] <h3>Objectives</h3> The aim of this study was to investigate steroid management and referral patterns for GCA amongst UK GPs. <h3>Methods</h3> A postal questionnaire survey of 5000 randomly selected UK GPs was undertaken. Questions included experience of managing patients with GCA, initial steroid doses used and the referral pathways of suspected GCA. <h3>Results</h3> 1249 GPs responded (corrected response rate of 25.1%). Responders had a mean age of 44 years (SD 9.2) and had been qualified as a GP for a mean of 14 (SD 9.03) years. Respondents were more likely to be from larger practices. 879 responders (70.4%) indicated that they had diagnosed and managed a patient with GCA. The most common initiating dose of prednisolone was 60mg, although this varied widely (figure 1). Once GPs had suspected the diagnosis, 478 respondents (38.3%) indicated that they refer to rheumatology, 366 (29.3%) would refer to ophthalmology, 144 (11.5%) would refer to general medicine and 35 (2.8%) would refer to accident and emergency. Table 1 illustrates the action taken by respondents when GCA is suspected. <h3>Conclusions</h3> These results show that there appears to be wide variation amongst responders in how suspected GCA is managed in general practice. This is likely to be due to variation in the availability of relevant services. However, it may also reflect GPs training and previous experience. Referral pathways that allow urgent specialist review for diagnostic confirmation are essential to avoid the serious complications of GCA, but also inappropriate over treatment of patients who do not have the disorder. <h3>References</h3> Dasgupta B et al. Rheumatology (Oxford). 2010 Aug;49(8):1594-7. <h3>Acknowledgements</h3> Administration and support staff at Keele University Department of Primary Care and Health Sciences. IT Staff Zoe Mason and Ashley Ford <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4756
Effect of chlamydia pneumoniae (Cpn) infection on cytokine profiles of PBMC from asthmatics and healthy subjects
Authors: S. Kohlhoff, P. Roblin, A. Kutlin, S. Strigl, R. Joks, R. Joks, M. Nowakowski, M.R. Hammerschlag
Journal: Journal of Allergy and Clinical Immunology (2005)
Abstract 5618: Polymorphisms in DNA repair genes are associated with endometrial cancer risk among Japanese women
Authors: Satoyo Hosono, Keitaro Matsuo, Hidemi Ito, Kaoru Hirose, Miki Watanabe, Toru Nakanishi, Kazuo Tajima, Hideo Tanaka
Journal: Cancer Research (2011)

Abstract Common polymorphisms in DNA repair genes may affect an individual's capacity to repair damaged DNA. Although many former studies have reported an association between several types of cancers and DNA repair polymorphism, the association with endometrial cancer (EC) risk has not been investigated fully, especially in Asian population. To examine the association between DNA repair polymorphisms and postmenopausal EC risk, we conducted a case-control study with 91 EC cases (59 endometrioid adenocarcinoma and 32 other types of carcinoma) and 261 non-cancer female controls from database of Hospital based Epidemiologic Research Program at Aichi Cancer Center. We examined 16 coding SNPs (single nucleotide polymorphism) of 12 DNA repair genes (OGG1, MUTYH, XRCC1, APE1, ADPRT, XPA, XPC, XPD, ERCC1, RAD23B, XPG, ERCC6) by TaqMan Methods. We surveyed lifestyle/environmental information by self-administered questionnaire. Impact of each SNPs on EC risk was evaluated by multivariate unconditional logistic regression models. Further, we examined the gene-gene interaction. We observed significant association between EC risk and rs1799782 (C&amp;gt;T, Arg194Trp) of XRCC1 [CT: Odds ratio (OR) = 1.74, 95% confidence interval (95% CI) = 0.99-3.04, TT: OR = 2.76, 95% CI = 1.23-6.16; trend p = 0.007]; rs25487 (G&amp;gt;A, Arg399Gln) of XRCC1 [GA: OR = 0.66, 95% CI = 0.39-1.12, AA: OR = 0.15, 95% CI = 0.02-1.16; trend p = 0.019]; rs1136410 (T&amp;gt;C, Val762Ala) of ADPRT [TC: OR = 1.49, 95% CI = 0.84-2.64, CC: OR = 1.92, 95% CI = 0.88-4.18; trend p = 0.076]; and rs17655 (G&amp;gt;C, Asp1104His) of XPG [GC: OR = 0.68, 95% CI = 0.39-1.21, CC: OR = 0.54, 95% CI = 0.26-1.12; trend p = 0.082]. Although both XRCC1 and ADPRT involve in base excision repair, gene-gene interaction of these polymorphisms were not significant; the interaction p between rs1799782 and rs25487 was 0.687; that between rs25487 and rs1136410 was 0.328. In conclusion, we found significant association between EC risk among postmenopausal Japanese women and DNA repair polymorphisms. Gene-gene interactions between XRCC1 and ADPRT were not significant. These results suggests that DNA repair polymorphisms might be associated with etiology of EC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5618. doi:10.1158/1538-7445.AM2011-5618
Abstract 2099: Tid1 regulates galectin-7 mediated tumorigenesis of oral squamous cell carcinoma
Authors: Yi-Chen Wu, Lu-Ying Huang, Jeng-Fan Lo
Journal: Cancer Research (2011)

Abstract Background: We previously identified Tid1, a DnaJ cochaperon protein, functions as a tumour suppressor in oral squamous cell carcinoma (OSCC) tumourigenesis (J Pathol 2009;219:347-55). To further understand the molecular mechanisms mediated by Tid1 on oral tumorigenesis, we applied affinity chromatography and systemic proteomics analysis to identify galectin-7, which specifically interacted with Tid1. Others have shown that Galectin-7 plays a number of important roles in tumor development. However, the role of Galectin-7 in OSCC tumourigenesis remains unclear. Herein, we elucidated the mechanism mediated by Tid1 on regulating galectin-7 mediated cellular signaling and tumorigenesis in OSCC. Methods: First, through HA-tag affinity chromatography and mass spectrometry we identified substrate proteins that specifically interact with Tid1. Secondly, co-immunoprecipitation analysis and confocal microscope was performed to confirm the protein-protein interaction between galectin-7 and Tid1. In vitro tumorigenic properties of OSCC overexpressing galectin-7 were determined. Subsequently, the tumorigenic properties of OSCC after co-overexpression of galectin-7 and Tid1 were investigated. Finally, immunoprecipitation analysis was performed to recognize the Tid1 induced deregulation of galectin-7 by enhancing ubiquitination. Results: We found out that Tid1 interacted with galectin-7. Furthermore, overexpression galectin-7 expression resulted in up-regulation migration, invasion and soft agar colony formation abilities in OSCC. Importantly, co-overexpression of Tid1 decreased the galectin-7 expression and impaired galectin-7-mediated migration, invasion and soft agar colony formation ability of OSCC. Finally, we found galectin-7 ubiquitination as revealed by antiubiquitin immunoblot analysis in immunoprecipitates. Conclusion: Our studies first pointed out that galectin-7 played pivotal roles in OSCC tumorigenesis. Notably, we identified galectin-7 that specifically interacted with Tid1. We hypothesized that Tid1/ Hsp70 may regulate galectin-7 stability by ubiquitinylation. The molecular mechanism by which Tid1 negatively modulates the galectin-7 warrants further investigation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2099. doi:10.1158/1538-7445.AM2011-2099
PTU-074 Anatomic vs non-anatomic resection of colorectal liver metastases: a comparison of surgical and oncological outcomes
Authors: C P Neal, G Garcea, C Moreman, A McGregor, C D Mann, V Cairns, M S Metcalfe, A R Dennison
Journal: Gut (2012)

<h3>Introduction</h3> Non-anatomic resections (NAR) for colorectal liver metastases (CRLM) have become increasingly common in an attempt to increase resection rates and to enable parenchyma-preserving resections, though some investigators have reported NAR to be associated with higher rates of resection margin positivity and poorer long-term survival than anatomic resections (AR). The aim of this study was to compare surgical outcomes, recurrence and survival in patients treated with NAR and AR. <h3>Methods</h3> Patients undergoing hepatic resection for CRLM between January 2002 and December 2008 were identified from a prospectively maintained database. Patients were divided into two groups: those who underwent AR and those who underwent NAR. Patients who underwent simultaneous AR and NAR were excluded from analysis. Clinicopathological variables and perioperative outcomes, as well as long-term disease-free and overall survival were compared between the AR and NAR groups, using the χ<sup>2</sup> test, Mann–Whitney U test, logistic regression analysis, log-rank analysis and multivariable Cox regression analysis employing a backwards stepwise model. <h3>Results</h3> Over the study period 91 patients underwent AR and 77 patients underwent NAR. Perioperative (90-day) morbidity, major morbidity and mortality occurred in 25.0%, 8.3% and 1.8% of cases respectively. There was no significant difference in rates of perioperative morbidity, major morbidity or mortality according to resection type (all p&gt;0.30). There was also no difference in the incidence of positive resection margins between resection types (p=0.413). Overall survival was 48.5% and 36.6% at 3 and 5 years respectively, with disease-free survival of 31.4% and 25.3% at 3 and 5 years respectively. Type of resection was not associated with any significant difference in overall (p=0.430) or disease-free survival (p=0.625) following metastasectomy. <h3>Conclusion</h3> AR is not superior to NAR in terms of perioperative risk, tumour clearance, time to recurrence or long-term survival following metastasectomy. NAR should remain an integral component of the surgical treatment of CRLM and may enable increasing rates of operability. Furthermore, the preservation of hepatic parenchyma by NAR may enable a larger proportion of patients subsequently developing recurrent metastatic disease to undergo repeat metastasectomy. <h3>Competing interests</h3> None declared.
Diabetes Prevalence in Relation to Serum Concentrations of Polychlorinated Biphenyl (PCB) Congener Groups and Three Chlorinated Pesticides in a Native American Population
Authors: Zafar Aminov, Richard Haase, Robert Rej, Maria J. Schymura, Azara Santiago-Rivera, Gayle Morse, Anthony DeCaprio, David O. Carpenter
Journal: Environmental Health Perspectives (2016)

Exposure to persistent organic pollutants (POPs) is known to increase risk of diabetes.
Bilateral Spreading Cerebral Hypoperfusion during Spontaneous Migraine Headache
Authors: Roger P. Woods, Marco Iacoboni, John C. Mazziotta
Journal: New England Journal of Medicine (1994)

Although decreases in regional cerebral blood flow are known to occur in relation to migraine headache, the pattern of the alterations in blood flow has not been precisely delineated. Olesen et al. have described a series of patients who had migraine headaches during serial cerebral blood-flow measurement by the intracarotid xenon-133 technique.1 They observed a pattern of localized decreases in flow that appeared to spread contiguously along the cerebral cortex. These observations were confirmed in subsequent studies,2,3 and with very few exceptions1,4 the pattern of “spreading oligemia” or “spreading hypoperfusion”5 has been apparent only in patients who have . . .
Diagnosis of deep-seated lymphomas by endoscopic ultrasound guided fine needle aspiration combined with flow cytometric analysis
Authors: C De Angelis, A Stacchini, P Carucci, D Pacchioni, M Goss, G Accinelli, A Demurtas, S Aliberti, M Bruno, F Brizzi, P Allegranza, D Reggio, M Rizzetto
Journal: Endoscopy (2011)

Objective: Endoscopic ultrasound combined with fine needle aspiration (EUS-FNA) is rapidly becoming the preferred diagnostic approach for the sampling and diagnosis of gastrointestinal and mediastinal malignancies; limited data however exist regarding its use in the diagnosis of lymphoproliferative disorders. We retrospectively evaluated the performance of EUS guided FNA combined with flow cytometry (FC) as a tool to improve overall sensitivity and specificity in the diagnosis of lymphoma.
The Side Effects of Aspirin
Authors: F. J. Ingelfinger
Journal: New England Journal of Medicine (1974)

Seen from a broad perspective, aspirin is probably the world's most useful analgesic. Yet the opinion physicians have of this agent appears to be influenced more by its side than by its principal effects. Recently, after reports that aspirin might decrease the mortality1 and frequency2 of myocardial infarction, the stock of aspirin surged upward, thus reversing a downward trend brought about by its indictment for a legion of adverse effects. Aspirin has been said or shown to interfere with platelet function, to cause allergic reactions in the sensitive, to induce exfoliation of renal epithelial cells, to initiate gastric and to . . .
O8.02 * MONITORING OF TREATMENT RESPONSE IN IDH-MUTANT GLIOMAS WITH IN-VIVO 3D MAGNETIC RESONANCE SPECTROSCOPY
Authors: D. P. Cahill, F. Loebel, W. Bogner, M. Marjanska, E. Gerstner, T. Batchelor, B. R. Rosen, A. Chi, O. C. Andronesi
Journal: Neuro-Oncology (2014)

The hallmark metabolic alteration in mutant IDH gliomas is the production of R-2-hydroxyglutarate (2HG). 2HG can be measured in-vivo by magnetic resonance spectroscopy of patients, representing an ideal biomarker for IDH mutant gliomas. 3D mapping of 2HG and other metabolites is important to capture tumor heterogeneity and for longitudinal studies where changes in size and shape of tumors during treatment makes positioning of a single voxel or a single slice difficult to appropriately match over time. A 3D 2HG map provides selectivity and specificity for the spatial extent of tumor in all directions, and can thereby reduce variance in longitudinal MRS studies. Here we present results obtained with a 3D MR spectroscopic imaging (MRSI) that edits 2HG with high efficiency. Measurements were performed in 20 mutant IDH1 glioma patients who were consented under an IRB-approval. A robust and efficient 3D MRSI sequence for 2HG imaging was newly developed. Spectra were fitted with LCModel software and metabolic maps were obtained from the fitted signal. All experiments were performed on a whole-body 3T MR scanner (Tim Trio with VB17 software, Siemens, Erlangen), using body coil for transmit and a 32-channel head coil for receive. Prior to receiving adjuvant therapy, detectable levels of 2HG were measured in all patients that had not undergone gross total resection. 3D metabolic maps were obtained for 2HG and several important metabolites for assessing brain tumors, such as total choline (Cho), N-acetyl-aspartate (NAA), glutamate and glutamine (Glx), and lactate (Lac). All metabolites were measured simultaneously within a single acquisition, 2HG and Glx maps were obtained from the difference spectra, while the other metabolites were obtained from the off-resonance spectra. In 9 patients who have undergone both pre- and post-treatment scans, 4 demonstrated marked decrease in the level of 2HG at the first time point after completion of adjuvant therapy. The remainder demonstrated partial reduction of 2HG, with no patients demonstrating increased 2HG levels. We demonstrate 3D imaging of 2HG is clinically feasible in patients with IDH1 mutated gliomas. Further validation and development is underway for longitudinal quantification of 2HG levels during treatment of IDH mutant gliomas. Acknowledgements: Burroughs-Wellcome Career Award, NCI/NIH 1K22CA178269-01 and 1P50CA165962-01, Harvard-MIT Koch Institute Bridge Project.
Cysto-duodenal fistula: an unusual complication of a nonparasitic hepatic cyst
Authors: Jung Kim, Chang Lee, Jae Shim, Jae Jang
Journal: Endoscopy (2013)

Increasing use of radiological imaging modalities has resulted in the detection of nonparasitic hepatic cysts in 1 % – 5 % of the general population, however, complicated nonparasitic hepatic cysts are exceedingly rare [1] [2] [3] [4]. Here, we present a unique case of a hepatic cysto-duodenal fistula with the intracystic endoscopic findings.
Chelating Agents in the Therapy of Beryllium Poisoning
Authors: Ralph Cash, Reuben I. Shapiro, Stanley H. Levy, Scovell M. Hopkins
Journal: New England Journal of Medicine (1959)

PNEUMONOCONIOSIS associated with heavy-metal inhalation has long resisted most forms of therapy. The development of chelating agents offers a new approach to this problem. This report concerns our efforts to study the effect of ethylenediamine tetra-acetic acid (EDTA) on the urinary excretion of beryllium in 2 patients with beryllium pneumonoconiosis. After beryllium pneumonoconiosis had been proved in these cases by lung biopsy a trial of chelation therapy was suggested as a useful adjuvant in the treatment of this disease. Certain theoretical considerations led us to believe that this agent might be effective in lowering the body stores of ionized beryllium. . . .
P155 Are we utilising CT pulmonary angiography appropriately in the diagnosis of suspected pulmonary embolism? A three month review in a district general hospital
Authors: SE Fernandes, N McDonald
Journal: Thorax (2013)

<h3>Introduction</h3> CT pulmonary angiography (CTPA) is the recommended imaging modality for suspected pulmonary embolism (PE). Current NICE guidelines recommend using clinical prediction scoring systems to estimate the probability of PE and guide further investigation[i]. A low or intermediate probability score, coupled with a negative D-dimer, reliably excludes PE, thereby avoiding the need for CTPA. <h3>Objectives</h3> We undertook a retrospective audit to examine adherence to NICE guidelines for diagnosis of suspected PE in patients admitted to a district general hospital, and identify patients who may have undergone unnecessary CTPA. <h3>Methods</h3> We obtained a list of all CTPAs undertaken in our hospital between December 2012 and February 2013. D-dimer tests are poorly specific within hospitalised patients; therefore, we excluded post-surgical and obstetric patients, and pre-existing inpatients where primary admission was not for suspected PE. We also excluded outpatient CTPAs. We searched the records for contemporaneous PE probability scores and D-dimer results. For patients without a probability score result, we reviewed the clinical notes and calculated a probability score retrospectively using a local scoring system adapted from BTS guidelines. <h3>Results</h3> There were 115 CTPAs during the study period – 36 were excluded and 4 patients’ case notes were unavailable. 75 patients fulfilled the inclusion criteria (mean age 68.2 years), and PE was confirmed in 20%. 50 patients (66.7%) had a contemporaneous documented clinical probability score. There were 5 patients (6.7%) with a low/intermediate probability score and negative D-dimer, who underwent unnecessary CTPA (PE excluded in each case). There were 9 patients (12%) with retrospectively calculated low/intermediate clinical probability scores and no D-dimer result, who may have avoided CTPA had D-dimer been undertaken (CTPA excluded PE in each case). <h3>Conclusions</h3> In our district general hospital, the underuse of clinical probability scoring and D-dimer testing in patients with suspected PE is contributing to unnecessary CTPAs. Introducing mandatory documentation of PE clinical probability score on CTPA request forms may reduce the number of unnecessary CTPAs. <h3>References</h3> National Institute for Health and Clinical Excellence (2012) Venous thromboembolic diseases: the management of venous thromboembolic diseases and the role of thrombophilia testing. Clinical Guideline 144. London: NICE.
Study Suggests Mechanism for Alcohol-Breast Cancer Link
Authors: N. S. Larsen
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Study Suggests Mechanism for Alcohol-Breast Cancer Link Get access Natalie S. Larsen Natalie S. Larsen Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 9, 5 May 1993, Pages 700–701, https://doi.org/10.1093/jnci/85.9.700 Published: 05 May 1993
Sarcoidosis with Musculocutaneous Involvement
Authors: AJAY K. SINGH, HOWARD J. DWORKIN, CHRISTINE Z. DICKINSON, PALLAVI SAGAR
Journal: Clinical Nuclear Medicine (2001)

SINGH, AJAY K. M.D.; DWORKIN, HOWARD J. M.D.; DICKINSON, CHRISTINE Z. M.D.; SAGAR, PALLAVI M.D. Author Information
1245 ROLE OF INNATE AND ADAPTIVE IMMUNITY IN THE DEVELOPMENT OF NON ALCOHOLIC FATTY LIVER DISEASE IN MORBIDLY OBESE PATIENTS
Authors: M.T. Arias Loste, P. Iruzubieta, R.A. Domínguez, M. Mallorga, M. López Hoyos, D. San Segundo, L. Alvarez Rodriguez, J. Crespo
Journal: Journal of Hepatology (2013)
Defective Myelopoiesis in Congenital Neutropenia
Authors: Karin Wriedt, Emanuel Kauder, Alvin M. Mauer
Journal: New England Journal of Medicine (1970)

Two patients with congenital neutropenia were found to have abnormalities of the immature myeloid cells. These cells were incapable of complete differentiation to a mature stage and also had a substantial reduction in their capacity for cell proliferation. The defect in one patient appeared to be intrinsic to an abnormal cell line, but in the other bone-marrow environmental factors may have contributed to the defect in maturation and proliferation. The surprisingly benign clinical courses may be explained by compensatory defense mechanisms.
Concurrent Axial and Appendicular Osteoporosis
Authors: Richmond W. Smith, Boy Frame
Journal: New England Journal of Medicine (1965)

OSTEOPOROSIS of aging has long been recognized as a disorder primarily of the dorsolumbar spine. Evidence that bone loss with age also occurs in the appendicular skeleton has been summarized by Garn and his associates1 and extended by them and by other investigators.2 3 4 5 However, the relation of peripheral bone to vertebral atrophy has received only limited attention.2 , 4 Not only is the concept that this osteoporosis results from an osteoblast-matrix defect secondary to hormonal imbalance6 still to be proved but interest has been redirected to the earlier point of view that a calcium consumption inadequate to permit a positive mineral balance . . .
ACHIEVEMENT OF OPTIMAL MEDICAL THERAPY IMPROVES CLINICAL OUTCOMES IN PATIENTS TREATED WITH DRUG-ELUTING STENTS: SUB-ANALYSES FROM THE J-DESSERT TRIAL
Authors: Raisuke Iijima, Masato Nakamura, Hiroyoshi Yokoi, Toshiya Muramatsu, Shinsuke Nanto
Journal: Journal of the American College of Cardiology (2016)
Health Care in the 2010 Congressional Election
Authors: Robert J. Blendon, John M. Benson
Journal: New England Journal of Medicine (2010)

Eight months after the enactment of historic health care reform legislation (the Patient Protection and Affordable Care Act), the country faces a midterm congressional election with all seats inthe House of Representatives and one third of Senate seats up for election. The election has significance for health care because most of the provisions of the national reform law do not take effect for years, and some of them could be altered by the next Congress. Such alteration might involve expanding the government's role in the plan — for example, by adding a public insurance option to compete with those of . . .