tbuckley/cabot-search huggingface dataset:
MNGO-18SCHWANNOMA RESPONSE TO CONCURRENT TREATMENT WITH INTERFERON ALPHA FOR METASTASTIC MELANOMA: A CASE REPORT
Authors: Wendy Sherman, Todd Vitaz
Journal: Neuro-Oncology (2015)

Non-malignant schwannomas are typically treated with surgery, radiation, or a combination of the two modalities. There is no defined role for medical therapy, though perhaps there is a need as these treatment modalities can result in neurologic deficits in this patient population. We present a case of a patient with a cerebellopontine (CP) angle tumor identified during staging for metastatic melanoma after presenting with ipsilateral trigeminal neuralgia. He was treated with one month of interferon alpha for his metastatic melanoma with subsequent partial response of his CP angle tumor, though was ultimately resected given intractable trigeminal neuralgia. Interferon alpha has been studied in meningiomas, overall demonstrating moderate toxicity with limited efficacy, despite anti-proliferation activity in in-vitro studies. This case study demonstrating a partial response in a patient with schwannoma and should be considered for future studies in patients with recurrent disease after surgery and radiation or in patients where those modalities are not indicated.
Allogeneic Hematopoetic Transplantation for CLL: Results of Combination Chemotherapy as Pre-Transplant Targeted Lymphocyte Depletion on Disease Response, Donor Chimerism, and Transplantation Outcomes.
Authors: Brian C Shaffer, Marko Modric, David Liewehr, Maryalice Stetler-Stevenson, Diane C Arthur, Seth Steinberg, Frances T Hakim, Kelly Bryant, Jeanne Odom, Paula Layton, Rachel B Salit, Christoph Rader, Ronald E Gress, Daniel H Fowler, Michael R Bishop, Steven Z Pavletic
Journal: Blood (2010)
Detection of Circulating Plasma Cells in Multiple Myeloma with Extramedullary Plasmacytoma
Authors: Jing Wang, Shuang Geng, Yuping Zhong, Mingyi Chen, Wenming Wang, Yuhong Pang, Jiajia Zhang, Yuanyuan Liu, Yanyi Huang, Hongmei Jing
Journal: Blood (2015)
Phase III Trial of Pixantrone Dimaleate Compared with Other Agents as Third-Line, Single-Agent Treatment of Relapsed Aggressive Non-Hodgkin's Lymphoma (EXTEND): Results From the Treatment and Follow-up Periods.
Authors: Ruth Pettengell, Bertrand Coiffier, Geetha Narayanan, Fernando Hurtado de Mendoza, Raghunadharao Digumarti, Henry Gomez, Pier Luigi Zinzani, Gary J Schiller, David A Rizzieri, Paul Cernohous, Lixia Wang, Jack W. Singer
Journal: Blood (2009)
MODULATORS OF PROTEIN-KINASE-C AS WELL AS SUBSTRATES FOR THE P-GLYCOPROTEIN (MDR) SYSTEM HAVE A MAJOR INFLUENCE ON THE BILIARY-EXCRETION OF THE CATIONIC DRUG TRI-NORMAL-BUTYLMETHYLAMMONIUM (TBUMA)
Authors: H Steen, A Nijholt, Dirk Meijer, Maja Merema
Journal: Hepatology (1992)
Herpes Zoster (HZ) Complicating Bortezomib Therapy of Relapsed/Refractory Indolent B-Cell and Mantle Cell Lymphoma: An Analysis of Two Phase II Trials.
Authors: Vicki A. Morrison, Richard I Fisher, Andre Goy, Sven de Vos, Steven H. Bernstein, Anthony Boral, Rachel Neuwirth
Journal: Blood (2010)
AB0107 Association Heterogeneity Mapping Identifies An Asian-Specific Association of The GTF2I Locus with Rheumatoid Arthritis
Authors: K. Kim, S.-Y. Bang, K. Ikari, D.H. Yoo, S.-K. Cho, C.-B. Choi, Y.-K. Sung, T.-H. Kim, J.-B. Jun, Y.M. Kang, C.-H. Suh, S.-C. Shim, S.-S. Lee, J. Lee, W.T. Chung, S.-K. Kim, S. Momohara, A. Taniguchi, H. Yamanaka, S.K. Nath, H.-S. Lee, S.-C. Bae
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Genetic association studies using multiple ancestral cohorts have revealed a large overlap of rheumatoid arthritis (RA)-risk alleles among different ancestries, but there are some exceptional loci showing heterogenic association among populations. <h3>Objectives</h3> Here we investigated genetic variants with distinct effects on the development of RA in Asian and European populations. <h3>Methods</h3> Ancestry-related association heterogeneity was examined using the association data from large Korean (n=9,299) and European (n=45,790) rheumatoid arthritis cohorts with Immunochip and genome-wide SNP array data. Novel disease associations detected in Koreans were validated using two independent Asian cohorts (n=5,166) and a meta-analysis. <h3>Results</h3> We identified significant heterogeneity between the two ancestries for the common variants in the <i>GTF2I</i> locus and showed that this heterogeneity is due to an Asian-specific association effect (<i>P</i><sub>Heterogeneity</sub> =9.6×10<sup>-9</sup> at rs73366469 [OR<sub>Meta</sub> =1.37 and <i>P</i><sub>Meta</sub> =4.2×10<sup>–13</sup> in Asians; OR<sub>Meta</sub> =1.00 and <i>P</i><sub>Meta</sub> =1.00 in Europeans]) in RA. Trans-ancestral comparison and bioinfomatics analysis revealed a plausibly causal SNP (rs117026326; linked to rs73366469), whose minor allele is common in Asians but rare in Europeans. <h3>Conclusions</h3> We identified the largest effect on Asian RA across human non-HLA regions at <i>GTF2I</i> by heterogeneity mapping followed by replication studies, and pinpointed a possible causal variant. <h3>References</h3> Okada, Y. et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506, 376–81 (2014). Kim, K. et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis 74, e13 (2015). <h3>Acknowledgement</h3> This study was supported by the Korea Healthcare Technology R&amp;D Project of the Ministry for Health &amp; Welfare (HI13C2124), the Japanese Ministry of Education, Culture, Sports, Science and Technology Grant-in-Aid for Scientific Research (15H04965) and the US National Institutes of Health (R01MD007909 and R01AR060366). *Drs. Kwangwoo Kim and So-Young Bang contributed equally to this work. <h3>Disclosure of Interest</h3> None declared
Analysis of Aurora Kinase Expressions and Cell Cycle Regulation by Aurora-C in Leukemia Cells.
Authors: Miki Kobayashi, Satoki Nakamura, Takaaki Ono, Yuya Sugimoto, Naohi Sahara, Kaori Shinjo, Kazuyuki Shigeno, Kazunori Ohnishi
Journal: Blood (2006)
Concurrent BCL2 and MYC Translocations In a Prospective Cohort of Diffuse Large B-Cell Lymphomas
Authors: Mette Ølgod Pedersen, Anne Ortved Gang, Tim Svenstrup Poulsen, Helle Knudsen, Anne F. Lauritzen, MajLis M Talman, Signe Ledou Nielsen, Peter H Norgaard
Journal: Blood (2010)
Prior Response to Imatinib Predicts Response to Second Line Treatment with Nilotinib in CML Patients Resistant or Intolerant to Imatinib.
Authors: Maya Koren-Michowitz, Philipp D. le Coutre, Justus Duyster, Christof Scheid, Panayiotis Panayiotidis, Witold Prejzner, Jacob M. Rowe, Michaela Schwarz, Neta Goldschmidt, Arnon Nagler
Journal: Blood (2009)
Upregulation of Cereblon Expression By the DNA Methyltransferase Inhibitor Azacytidine Strongly Enhances Lenalidomide Cytotoxicity in Germinal Center B-Cell-like (GCB) and Activated B-Cell-like (ABC) Diffuse Large B-Cell Lymphoma (DLBCL)
Authors: Silvia L Locatelli, Roberto Papait, Giuseppa Careddu, Ada Koschorke, Giuliano G Stirparo, Monica Balzarotti, Luca Castagna, Armando Santoro, Carmelo Carlo-Stella
Journal: Blood (2014)
Proposal of a New Prognostic Scoring System for Myelodysplastic Syndromes (MDS) Based on the Immunophenotypic Features of CD34+ Myeloid Precursors
Authors: Alex Freire Sandes, Alberto Orfao, Antonio López, Maria de Lourdes L.F. Chauffaille, Tsutomu Oguro, Juan Flores, Sergio Matarraz, Eliza YS Kimura, Marçal CA Silva, Mihoko Yamamoto
Journal: Blood (2008)
The Effect of Insulin-Like Growth Factor 1 on Waldenstrom Macroglobulinemia
Authors: Molly R. Melhem, Aldo M. Roccaro, Mena Farag, Abdel kareem Azab, Hai T. Ngo, Antonio Sacco, Xiaoying Jia, Feda Azab, Judith Runnels, Nicolas Burwick, Phong Quang, Emanuel N. Husu, Hideshima Teru, Kenneth C. Anderson, Xavier Leleu, Irene M. Ghobrial
Journal: Blood (2008)
The Clinical Impact of Time to Response in De Novo Accelerated Phase Chronic Myeloid Leukemia (CML-AP)
Authors: Maro Ohanian, Hagop M. Kantarjian, Alfonso Quintas-Cardama, Elias J. Jabbour, Srdan Verstovsek, Gautam Borthakur, Farhad Ravandi, Guillermo Garcia-Manero, Alessandra Ferrajoli, Tapan M. Kadia, Susan O'Brien, Jorge E. Cortes
Journal: Blood (2012)
Abstract 5209: Non-tumoral autotaxin stored into platelet α-granules promotes breast cancer cell metastasis
Authors: Raphael Leblanc, Sue-Chin Lee, Dereck Norman, Johnny Ribeiro, Gabor Tigyi, Olivier Peyruchaud
Journal: Cancer Research (2015)

Abstract Autotaxin (ATX) through its lysophospholipase D activity controls physiological levels of lysophosphatidic acid (LPA) in blood. ATX is overexpressed in multiple types of cancers and we have shown previously that together with LPA generated during platelet activation promotes skeletal metastasis of breast cancer. However, the mechanisms that regulate the pathophysiological significances of the interactions between circulating LPA, ATX, and platelets remain undefined in cancer. Here we show that ATX is stored in α-granules of resting human platelets and released upon tumor cell-induced platelet aggregation, leading to the production of LPA. For this study, we used two human breast cancer cell lines (MDA-MB-231, MDA-B02) that do not express ATX. Our in vitro and in vivo experiments demonstrate that non-tumoral ATX controls the early stage of bone colonization by tumor cells and to a less extent osteolytic bone metastasis progression. Moreover, expression of a dominant negative integrin αvβ3-Δ744 or treatment with the anti human αvβ&amp;;3 monoclonal antibody LM609 completely abolished binding of ATX to tumor cells, demonstrating the requirement of a fully active integrin αvβ3 in this process. The present results establish a new mechanism for platelet contribution to LPA-dependent metastasis of breast cancer cells and demonstrate the therapeutic potential of disrupting the binding of non-tumor-derived ATX with the tumor cells for the prevention of metastasis. Citation Format: Raphael Leblanc, Sue-Chin Lee, Dereck Norman, Johnny Ribeiro, Gabor Tigyi, Olivier Peyruchaud. Non-tumoral autotaxin stored into platelet α-granules promotes breast cancer cell metastasis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5209. doi:10.1158/1538-7445.AM2015-5209
Phenotypically and Functionally Altered T Cell Compartment in DLBCL Patients at Diagnosis and Its Long-Term Modification upon Chemoimmunotherapy Regimen
Authors: Maria Christina Cox, Simone Battella, Raffaella La Scaleia, Arianna di Napoli, Sabrina Pelliccia, Alessandra Porzia, Fabrizio Mainiero, Bruno Monarca, Luigi Ruco, Angela Santoni, Gabriella Palmieri
Journal: Blood (2015)
AB0050 Detection of Interleukin-22 and Tumor Necrosis Factor Receptor Associated Factor 1 (TRAF1) in Patients with Rheumatoid Arthritis and Systemic Lupus Erythematosus: Correlation with Disease Activity:
Authors: N. Mohannad, E. Rashwan, M. Moaaz, E. Medhat
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> In autoimmune diseases including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), cytokines play a central role in initiating and maintaining diverse immune and inflammatory responses.In addition to IL-17A and F, Th17 cells also secrete IL-21, IL-22, and granulocyte macrophage colony-stimulating factor (GM-CSF). IL-22, member of IL-10 cytokine family, has been believed as an important player in regulating inflammatory responses associated with many inflammatory diseases. There is apparently a strong functional synergism of TNF-α and IL-22; the interaction of IL-22 &amp; TNF-α is mediated through TNFR I and IL-22R heterodimer and intracellularly by MAP kinases. The combination of IL-22 &amp; TNF-α strongly induced the phosphorylation and translocation of MAP kinases to the nucleus whereas the single cytokine only weakly contributed to MAP kinase activation. The discovery of the IL-22/TNF-α axis gives a first insight that could lead to new therapeutic approaches of RA. <h3>Objectives</h3> to evaluate the role of IL-22 and TRAF1 in patients (pts) with RA &amp; SLE, and their association to the disease activity. <h3>Methods</h3> 70 RA pts, 64 SLE pts aged &amp; 45 healthy matched controls were enrolled. DAS28 &amp; SLEDAI were used to assess activity. <h3>Results</h3> IL-22 was significantly higher in RA&amp;SLE pts than healthy controls. significant positive correlation was found between IL-22 levels and tender joints count, CRP and ESR. However, In SLE pts CRP only showed a positive correlation with IL-22 levels Analysis of TRAF1 polymorphism: in RA pts; the magnitude of association was increased in those patients who were autoantibody positive either RF+ or anti- CCP+. TRAF1 A allele was significantly associated with RF+ and anti-CCP+ RA patients when compared withcontrol. (OR =3.344 CI: 1.79–6.24, P&lt;0.001, OR =1.881 CI: 1.03–3.41 P&lt;0.034)respectively,in SLE pts, TRAF1 rs10818488 was not significantly different in pts and control <h3>Conclusions</h3> Theses results indicate that IL-22 is associated with inflammatory process and it has a role in RA and SLE pathogenesis and prognosis.Although there are inconsistent findings which need to be resolved, there are a synergism between TNF-α, IL 17 &amp; IL-22,mso,targeting IL-22 cytokine may be an effective therapeutic approach for chronic inflammation in the future.Also TRAF1 was significantly associated with RF positive, anti-CCP positive pts, ESR and tender joints count and this confirm importance of TRAF1 in progression of RA <h3>References</h3> Da Rocha et al. Increased serum interleukin 22 in patients with rheumatoid arthritis and correlation with disease activity. J Rheumatol 2012 <h3>Disclosure of Interest</h3> None declared
P0126 : The stroop App can predict the development of overt hepatic encephalopathy in a multi-center study
Authors: J.S. Bajaj, S. Allampati, A. Duarte-Rojo, K. Patidar, M. White, A. Unser, E. Gavis, J. Hovermale, D.M. Heuman, D.S. Barnes, B. John, J.S. Klair, C. Flud, L. Thacker
Journal: Journal of Hepatology (2015)
SQSTM1/p62 Is a Necessary Cofactor In MDS/AML With Deletion Of Mir-146a
Authors: Jing Fang, Brenden Barker, Lyndsey Bolanos, Xiaona Liu, Andres Jerez, Hideki Makishima, Dinesh S. Rao, James C. Mulloy, Jaroslaw P. Maciejewski, Jose A. Cancelas, Daniel T Starczynowski
Journal: Blood (2013)
Overall Outcomes of Bing-Neel Syndrome after Treatment - a Review of 40 Cases
Authors: Varinder Kaur, Al-Ola Abdallah, Arjun Swami, Shebli Atrash, Daisy V. Alapat, Zhifu Xiang, Pooja Motwani, Fade Mahmoud, Issam Makhoul, Peter Dean Emanuel
Journal: Blood (2015)
I am not a checklist.
Authors: Kaustubh G Joshi
Journal: BMJ (2016)

Graduating from medical school and completing residency training provided me with the skills to diagnose and treat patients, but it was one particular patient during my training who taught me how to be a doctor.

She was in her early 70s with hypertension and a history of cardiac stents. She presented for a follow-up appointment in the internal medicine …
SAT0451 The Association of Patella Alta with The Severity of Radiological Tibiofemoral Knee Osteoarthritis
Authors: I. Coskun Benlidayi, N. Cuzdan Coskun, T. Sarpel
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Patella alta is the malalignment of the patella in the vertical plane. There are a number of studies that confirmed the relation of patella alta and patellofemoral knee osteoarthritis (OA). Nevertheless, to our knowledge, none has studied the possible relationship between patella alta and tibiofemoral knee OA. <h3>Objectives</h3> The objectives of the current study were i) to determine the prevalence of patella alta among patients with radiographic tibiofemoral knee OA and ii) to evaluate whether the frequency of patella alta differs by the severity of knee OA. <h3>Methods</h3> Patients who had undergone X-ray examination of the knee with a diagnosis of knee OA between January 2013-February 2016 were included in the study. Following the application of the exclusion criteria, remaining patients9 radiographs were graded according to the Kellgren Lawrence grading system. Knees were divided into mild OA (KL grade 1–2) and severe OA (KL grade 3–4) groups. Computerized measurement of the craniocaudal patellar distance (CPD) and the patellar tendon length (PTL) was performed on lateral knee radiographs. According to the Insall-Salvati method, the PTL/CPD ratio &gt;1.2 was regarded as “patella alta”. The overall prevalence of patella alta was determined. The rate of patella alta was compared between mild and severe OA groups. <h3>Results</h3> A total of 712 radiographs were assessed for eligibility. Measurements were performed on 416 lateral knee radiographs belonging to 253 patients with a mean age of 62.7±11.3 years. The prevalence of patella alta in the whole group was 9.1%. The frequency of patella alta was significantly higher in the severe OA group when compared with the mild OA group (p&lt;0.001). <h3>Conclusions</h3> According to the results of the present study, patella alta appears to be associated with increased severity of radiographic tibiofemoral knee OA. “High riding” patella should be kept in mind as a determinant of disease severity in patients with knee OA. <h3>Disclosure of Interest</h3> None declared
OC-021 Should the Renal Tract be Routinely Investigated in Iron Deficiency Anaemia?
Authors: MS Lau, J Schembri, DS Sanders, JM Hebden
Journal: Gut (2016)

<h3>Introduction</h3> Iron deficiency anaemia (IDA) accounts for 4–13% of referrals to gastroenterology. The British Society of Gastronterology IDA guidelines recommend the investigation of the gastrointestinal (GI) tract, but not the renal tract. A single consultant led one stop IDA clinic was set up. As part of the evaluation of IDA, urine microscopy and an ultrasound or CT abdomen/pelvis (if used in lower GI tract examination) were performed to investigate for renal tract malignancies, alongside GI tract investigations. We aimed to demonstrate the yield of renal and GI tract malignancies in patients with IDA. <h3>Methods</h3> Patients with IDA or isolated hypoferritinaemia attending the clinic from 2013–2015 who underwent urine microscopy and an ultrasound or CT abdomen/pelvis alongside bidirectional GI investigations (Upper GI: gastroscopy/barium swallow/CT; lower GI: colonoscopy/barium enema/CT) were analysed. We described the yield of haematuria from urine microscopy and the yield of malignancy from renal and GI tract investigations. <h3>Results</h3> A total of 196 patients had renal tract investigations alongside bidirectional GI investigations (152 urinalysis/ultrasound, 44 urinalysis/CT). 6.1% (12/196) patients had microscopic haematuria. Four renal tract cancers were found: 2 from the haematuria group and 2 from the normal urine microscopy group. In the haematuria group, 2 bladder cancers were identified by CT and cystoscopy respectively. The latter patient was asymptomatic apart from gastroesophageal reflux and had no weight loss. He had a normal gastroscopy, colonoscopy and ultrasound abdomen. A cystoscopy was performed due to the persistent haematuria, which revealed a bladder cancer. In the normal urinalysis group, CT identified 1 prostate cancer and 1 renal cell carcinoma (RCC) where both patients presented with weight loss. The yield of renal tract malignancies in this cohort was 2.0% (4/196). The yield of GI malignancy was 3.1% (6/196) from bidirectional GI investigations in the same cohort of patients. All GI malignancies identified were colorectal cancers. <h3>Conclusion</h3> The ratio of renal: GI tract malignancies was 2:3 in this cohort. Urine microscopy identified 50% of renal tract cancers. Following the standard practice of bidirectional GI investigations for IDA, the 1 case of asymptomatic bladder cancer would have been missed had urine microscopy not been performed. Routine urine microscopy is easy and cheap to perform, and should be tested in all patients with IDA, and those with haematuria should have their renal tracts investigated. Routine renal tract ultrasound in the asymptomatic IDA patient is not indicated. <h3>Disclosure of Interest</h3> None Declared
Predictive Value of Bcl-2 and Bcl-6 Protein Expression in Diffuse Large B-Cell Lymphoma Patients from a Single Institution.
Authors: Ewa Paszkiewicz-Kozik, Olga Mioduszewska, Irena Federowicz, Ewa Kraszewska, Elzbieta Kulczycka, Katarzyna Domanska-Czyz, Beata Ostrowska, Joanna Romejko-Jarosinska, Michal Osowiecki, Jan A. Walewski
Journal: Blood (2004)
SP0196 Obesity and Diet in Experimental Models of OA
Authors: T. Griffin
Journal: Annals of the Rheumatic Diseases (2016)

Obesity is a significant modifiable risk factor for osteoarthritis in both weight bearing and non-weight bearing joints. Pre-clinical animal models of diet-induced obesity and genetic models of obesity provide new insight into the pathogenesis of obesity-induced osteoarthritis and the underlying cellular and molecular mechanisms involved in this process. Multiple mechanisms appear to be responsible for this increased risk, including biomechanical, inflammatory, post-traumatic, genetic, and metabolic factors. A central finding of many of these studies is that increased dietary lipids and adiposity promote osteoarthritis pathology, even independent of weight gain. Adipose tissue inflammation is considered a central mechanism by which obesity increases osteoarthritis risk, and I will present evidence from the literature and our recent findings that explore this link in obese animal models, focusing on systemic versus local sources (e.g., abdominal versus infra-patellar fat pad). These findings indicate that the infra-patellar fat pad is a source of inflammatory mediators but does not recapitulate the pathogenesis of inflammation that occurs with abdominal adiposity. Additional evidence suggests that obesity alters pathways regulating chondrocyte metabolism. I will discuss these findings and present a working model for how obesity-associated increases in chondrocyte lipid metabolism may impair the homeostatic response of chondrocytes to biomechanical and inflammatory stresses. <h3>Disclosure of Interest</h3> None declared