tbuckley/cabot-search huggingface dataset:
Adiopokine levels and the risk of gastric cancer: A case-control study
Authors: T. E. Nakajima, Y. Yamada, K. Furuta, T. Gotoda, K. Kato, T. Hamaguchi, Y. Shimada, H. Katai
Journal: Journal of Clinical Oncology (2008)

4582 Background: Adipokines are adipocyte-secreted hormones are associated with malignancies such as breast cancer. Adiponectin, one of the adipokines, has been reported also in experimental studies to inhibit tumor growth partly by a decrease in neovascularization. Most adipokines, however, have not been fully elucidated for the association with cancer, and few studies have been reported for gastric cancer. Methods: Blood concentrations of adiponectin, leptin, resistin, visfatin, and C-peptide, and body mass index (BMI) at diagnosis were measured in 156 patients with gastric cancer and 156 age- and sex-matched controls. Logistic regression models were used to estimate odds ratios and 95% confidence intervals, and one-way ANOVA analysis was conducted to examine prevalence of each variable between >2 groups. Results: Leptin, resistin, visfatin, C-peptide, and BMI levels significantly correlated with the risk of gastric cancer on univariate analysis p = 0.0060, <.0001, <.0001, <.0001 and <.0001, respectively). Multivariate analysis demonstrated significant associations of adiponectin, resistin, visfatin, C-peptide, and BMI levels with the risk of gastric cancer (p = 0.0004, 0.0006, 0.0013, 0.0006 and 0.0051, respectively). Resistin, visfatin and C-peptide levels were significantly associated with risk of Stage I/II gastric cancer (n=79) as compared with the controls on univariate analysis (p=0.0002, 0.0002 and 0.0001, respectively). Adiponectin, resistin and C-peptide levels were significantly associated with Stage I/II gastric cancer on multivariate analysis (p= 0.0029, 0.0118 and 0.0018, respectively). The pathological stage of gastric cancer significantly correlated with leptin, resistin, visfatin, C-peptide and BMI levels (p= <.0001, <.0001, <.0001, <.0001 and <.0001, respectively). Conclusions: Adiponectin, resistin, visfatin, C- peptide, and BMI levels are risk factors for gastric cancer. Adiponectin, resistin and C-peptide levels may be biomarkers of early stage gastric cancer, relatively unaffected by cachexia. Leptin, resistin, visfatin, C-peptide and BMI levels may be biomarkers of the progression of gastric cancer. No significant financial relationships to disclose.
A cluster of three cases of botulism due to Clostridium baratii type F, France, August 2015
Authors: Hélène Tréhard, Isabelle Poujol, Christelle Mazuet, Quentin Blanc, Yves Gillet, Frédérique Rossignol, Michel-Robert Popoff, Nathalie Jourdan Da Silva
Journal: Eurosurveillance (2016)

A cluster of three cases of food-borne botulism due to C lostridium baratii type F occurred in France in August 2015. All cases required respiratory assistance. Consumption of a Bolognese sauce at the same restaurant was the likely source of contamination. Clostridium baratii was isolated both from stool specimens from the three patients and ground meat used to prepare the sauce. This is the second episode reported in France caused by this rare pathogen.
Relation between Airway Responsiveness and Serum IgE in Children with Asthma and in Apparently Normal Children
Authors: M.R. Sears, B. Burrows, E.M. Flannery, G.P. Herbison, C.J. Hewitt, M.D. Holdaway
Journal: New England Journal of Medicine (1991)

Although asthma diagnosed by a physician is known to be related to serum IgE levels, it is not known whether there is a relation between the level of IgE and airway hyperresponsiveness to a methacholine challenge. The characteristics of asymptomatic persons that predispose them to airway hyperresponsiveness are also unknown.
Abstract 93: Genetic Deletion of Slc8b1, the Mitochondrial Sodium/Calcium Exchanger, Causes Sudden Cardiac Death and Overexpression Protects Against Myocardial Infarction and Pressure-Overload Heart Failure
Authors: Timothy S Luongo, Mary Nwokedi, Jonathan P Lambert, Erhe Gao, April C Carpenter, Muniswamy Madesh, Jeffery D Molkentin, John W Elrod
Journal: Circulation Research (2015)

Mitochondrial calcium ( m Ca 2+ ) signaling is critical for both energy production and the activation of cell death pathways in the heart. Further, m Ca 2+ overload is hypothesized to be a significant contributor to the development and progression of heart failure (HF). The mitochondrial sodium/calcium exchanger (mNCX) is hypothesized to be the primary mechanism of m Ca 2+ efflux, but to date no study has genetically confirmed its identity or function in an in vivo system. To investigate the role of mNCX in HF, we generated mutant mice with loxP sites flanking exons 5-7 of the candidate gene, Slc8b1 (also known as NCLX) , and crossed them with a tamoxifen (tamox)-inducible cardiac-specific Cre mouse to delete mNCX in the adult heart (mNCX-cKO). Cardiomyocytes isolated from mNCX-cKO mice displayed a significant reduction in m Ca 2+ efflux rate and Ca 2+ uptake capacity. Tamoxifen-induced ablation of mNCX resulted in sudden death with only 54% of mice surviving 8d post-tamoxifen treatment (Fig 1). Assessment of mNCX-cKO hearts 2d post-tamox revealed significant remodeling characterized by dilation and a decrease in %EF (Fig 2). Next, we generated a conditional, cardiac-specific mNCX overexpression mouse model (mNCX-Tg) to evaluate if increased m Ca 2+ efflux would alter the progression of HF. mNCX-Tg and controls were subjected to both myocardial infarction (LCA ligation) and pressure-overload induced HF (transverse aortic constriction). mNCX-Tg mice displayed preserved LV function, structure and a reduction in HF indices in both models. For the first time we show that mNCX is essential for m Ca 2+ efflux in cardiomyocytes and that mNCX represents a novel therapeutic target in HF.
Abstract 12262: Clinical and Echocardiographic Predictors of Bioprosthetic Valve Thrombosis
Authors: Alexander Egbe, Sorin V Pislaru, Patricia A Pellikka, Joeseph T Poterucha, Joeseph Maleszewski, Hartzell V Schaff, Heidi Connolly
Journal: Circulation (2015)

Background: Bioprosthetic valve thrombosis (BPVT) is considered uncommon; this may be related to the fact that it is often unrecognized. Our objectives were to determine the clinical characteristics of BPVT, and formulate a diagnostic model for BPVT. Methods: Patients requiring redo surgery after initial bioprosthetic valve (BPV) implantation were identified from the Mayo Clinic pathology database. Cases of BPVT were matched 2:1 with degenerated, non-thrombosed BPV. Multivariate linear logistic regression and receiver operating characteristic were used to formulate a diagnostic model for BPVT. Results: There were 46 BPVT cases identified between 1997-2013 (age=63 ±15, male=68%; aortic=29, mitral=9, tricuspid=7, pulmonary=1) and 92 controls matched by age, gender and prosthesis position. BPVT was present in 11.6% of 397 explants, and led to surgery significantly earlier than degeneration (median of 24 vs108 months, respectively, p&lt;0.001). Thirty (65%) of all BPVT occurred beyond 12 months post implantation. Predictors of BPVT were 50% increase in mean echo-Doppler gradient from baseline within 5 years (odds ratio [OR] 12.7), paroxysmal atrial fibrillation (OR 5.19), subtherapeutic INR (OR 7.37), increased cusp thickness (OR 12.2), and abnormal cusp mobility (OR: 6.94). Presence of all 5 diagnostic features was predictive of BPVT with 76% sensitivity, 93% specificity, 85% positive predictive value, and 89% negative predictive value, AUC=0.91, P&lt;0.0001. Conclusion: BPVT requiring reoperation occur in over 10% of patients receiving BPV and can occur several years after surgery. A combination of clinical and echocardiographic features can reliably diagnose BPVT. It is crucial to consider the diagnosis of BPVT prior to referring for reoperation since therapy with VKA may reverse the BPV dysfunction and prevent reoperation. Figure Legend: (A) Incidence of BPVT thrombosis (B) Freedom from BPV dysfunction (C) ROC curve for prediction of BPVT
Case 51-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, James C. McFarland, John T. Fallon
Journal: New England Journal of Medicine (1980)

Presentation of Case First admission. A 60-year-old woman was admitted to the hospital because of congenital heart disease.A heart murmur and skeletal anomalies were noted shortly after birth. Her early years were uneventful and free of symptoms. At the age of 39 years dyspnea developed, and atrial fibrillation was found; digitoxin was prescribed. Several years before admission exertional dyspnea increased in severity, and furosemide was prescribed. Five years before entry an echocardiogram demonstrated findings consistent with an atrial septal defect with right ventricular volume overload and pulmonary hypertension; a question of tricuspid prolapse was raised. Two years before . . .
A Genetic Study of Hereditary Orotic Aciduria
Authors: Harold J. Fallon, Lloyd H. Smith, John B. Graham, Charles H. Burnett
Journal: New England Journal of Medicine (1964)

HEREDITARY orotic aciduria is a disorder of pyrimidine metabolism manifested by megaloblastic anemia, leukopenia, retarded growth and the urinary excretion of large quantities of orotic acid.1 , 2 The disease was first described in a nine-month-old male infant with severe megaloblastic anemia that was refractory to vitamin B12 and folic acid therapy but responsive to the oral administration of prednisone and a yeast extract containing uridylic and cytidylic acids. With this improvement in the clinical manifestations of the disease the quantity of urinary orotic acid was reduced. The child died of an overwhelming varicella infection at two and a half years . . .
Gynecomastia in Association with Chronic Ulcerative Colitis
Authors: Laurence H. Kyle
Journal: New England Journal of Medicine (1949)

DURING recent months the problem of gynecomastia has received increasing attention, especially its association with impaired hepatic function1 , 2 and malnutrition.3 4 5 6 Among the complications of chronic ulcerative colitis, liver disease has most recently attracted attention.6 7 8 The following case report is that of a patient with chronic ulcerative colitis who showed both hepatic impairment and gynecomastia and whose clinical picture was of such a nature as to allow some speculation regarding the pathogenesis of the latter condition.Case ReportA 24-year-old man had been in excellent health until 1944. At that time he developed frequent, painful, urgent, bloody, often watery stools, together . . .
A First in Hemophilia B Therapy
Authors: Rebecca Voelker
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Mucociliary Clearance in Cystic Fibrosis
Authors: Joaquin Sanchis, Myrna Dolovich, Carol Rossman, William Wilson, Michael Newhouse
Journal: New England Journal of Medicine (1973)

Pulmonary clearance was examined by measurement of the rate of removal of a 99mTc-albumin aerosol (aerodynamic mass median diameter 3 μ) in 13 children with cystic fibrosis. Lung retention of radioactive label was monitored with a scintillation camera interfaced to a data-storage and retrieval system. The results were compared to those of nine normal adults. Overall lung retention was at all times greater in the normal subjects than in the patients (83.9 per cent at six hours after initial deposition vs. 59.6 per cent). The clearance curves of the patients had two exponentials with clearance half-times of 0.7 and 11.5 hours respectively. The mean curve for the normal subjects had a single exponential with half-times of 23.0 hours. In clinically stable patients with cystic fibrosis, clearance of inhaled aerosol from ciliated airways takes place at rapid rates, similar to those previously reported for mucociliary transport in normal adults.
Peritoneal Carcinomatosis (Pc) from Gastric Origin. 26 Consecutive Patients Treated By Radical Surgery (Crs) Plus Hyperthermic Intraperitoneal Chemotherapy (Hipec). Results from the Catalonian Peritoneal Carcinomatosis Programme (Spain)
Authors: G. Galofre, I. Ramos, O. Crusellas, J. Castellvi, F. Losa, G. Soler, V. Fuster, M. Martin, P. Barrios Sanchez
Journal: Annals of Oncology (2014)
P284 V/Q scanning using oxygen-enhanced Magnetic Resonance Imaging
Authors: JL Ulloa, AR Morgan, T Lacey, C Roberts, GJM Parker
Journal: Thorax (2015)

<h3></h3> Ventilation-perfusion (V/Q) scan is an established technique used to monitor lung dysfunction in conditions such as pulmonary embolism.<sup>1</sup> However, there are safety concerns regarding its use in several important populations e.g. pregnant women and children. Recent advances have transformed the use of standard clinical MRI equipment in functional lung imaging.<sup>2</sup> We recently presented a clinically appropriate dynamic oxygen-enhanced MRI (dOE-MRI) protocol.<sup>3</sup> In this work, we interpret dOE-MRI data with a novel physiological model of gas exchange<sup>4</sup> that maps the regional distribution of lung ventilation and perfusion, simulating results from a standard V/Q scan. 3D dOE-MRI data were acquired using a 1.5 T Philips scanner as in:<sup>3</sup> a 5 min baseline T<sub>1</sub> acquisition, followed by a 15 min dynamic acquisition, during which the subject breathed 100% O<sub>2</sub> for the middle 5 min. Total scan time is under 30 min throughout which the subject breathes normally. The partial pressure of oxygen in the alveolar compartment was derived as proposed in<sup>5</sup> and maps of regional alveolar ventilation and perfusion were produced using a novel two-compartmental model of gas exchange based on.<sup>4</sup> Figure 1 shows an example of whole-chest ventilation and perfusion maps from a healthy subject overlaid on a single volume of the acquired MRI (left column). The same maps are displayed as anterior/posterior and right/left anterior oblique projections (right column), equivalent to those achieved with V/Q scintigraphy.<sup>1</sup> Estimation of alveolar ventilation and perfusion distribution from 3D dynamic OE-MRI is feasible and can be obtained under clinically acceptable conditions using standard radiological equipment without ionising radiation risks. This approach opens the possibility for regional assessment of lung physiology using a single short scanning session. <h3>References</h3> 1 Bajc, <i>et al</i>.<i> Eur J Nucl Med Mol Imaging</i> 2009;<b>36</b>(8):1356–70 2 Wild, <i>et al</i>.<i> Insights Imaging</i> 2012;<b>3</b>(4):345–53 3 Ulloa, <i>et al</i>.<i> Proc Intl Soc Mag Reson Med</i>. 2015;<b>23</b>:3973 4 Naish, <i>et al</i>.<i> Proc Intl Soc Mag Reson Med</i>. 2010;<b>18</b>:2516 5 Kershaw, <i>et al</i>. <i>MRM</i> 2010;<b>64</b>:1838–42
A Phase Ii Trial of Abiraterone Acetate Plus Prednisone in Patients with Molecular Apocrine (Her2-Negative) Locally Advanced or Metastatic Breast Cancer: a Ucbg Study
Authors: A. Gonçalves, A. Mailliez, F. Dalenc, B. You, T. L'haridon, M. Leheurteur, O. Tredan, J. Ferrero, F. Del Piano, C. Alliot, B. Lucas, N. Dohollou, P.H. Cottu, J. Dauba, P. De Cremoux, J. Pierga, C. Orsini, M. Pulido, G. Macgrogan, H. Bonnefoi
Journal: Annals of Oncology (2014)
P-146 Stenting metastatic bile duct obstruction (BDO): the importance of liver function parameters
Authors: M. Bergamino Sirven, R. Montal, M. Galan, J. Gornals Soler, E. Escalante Porrua, V. Navarro Perez, M. Marin Melia
Journal: Annals of Oncology (2015)
Case 29-1963
Authors: George Nichols, Sanford I. Roth
Journal: New England Journal of Medicine (1963)

Presentation of Case First admission. A twenty-five-year-old school-teacher entered the hospital because of chills and fever.Five months before entry the patient experienced chills, fever and malaise, and after these symptoms subsided there were occasional mildly febrile episodes. Six weeks before admission she consulted a physician because of fatigue and was informed that she had a high blood pressure and that intravenous pyelograms were normal. Feverishness, headache and malaise recurred intermittently, and on the day before entry she had a shaking chill, with elevation of the temperature to 104.4°F. The blood pressure was 170 systolic, 100 diastolic; the urine . . .
Effect of CpG oligodeoxynucleotides on the growth of aggressive human B-cell lymphomas.
Authors: R. E. Yamada, D. J. Betting, M. Ahdoot, J. Timmerman
Journal: Journal of Clinical Oncology (2010)

8076 Background: Immunostimulatory CpG oligodeoxynucleotides (CpG ODN) are potent activators of T cell immunity and ADCC, and under study as immunotherapeutic agents for a variety of cancers, including B cell lymphomas. Recently, anti-CD20 antibody-CpG conjugates have been shown to eradicate rituximab-resistant B cell lymphoma in a syngeneic murine lymphoma model (D. Betting et al, ASCO 2009). CpGs strongly stimulate the proliferation of normal B cells. Paradoxically, CpG markedly inhibits the in vitro growth of the murine B-cell lymphoma A20, prompting us to investigate the direct effects of CpGs on the growth of human B cell lymphomas. Methods: A panel of 12 human lymphoma cell lines (DLBCL, Burkitt's, mantle cell) were cultured in the presence or absence of varying concentrations of CpGs of A, B, or C classes (50, 10, or 2 ug/ml) or control ODN. Proliferation was measured by 3H-thymidine incorporation in quadruplicate 72-hour cultures, and apoptosis measured by annexin V flow cytometry. Results: CpG ODNs strongly stimulated the proliferation of normal peripheral blood B cells (stimulation index for class B 27.5 at 5 ug/ml). In contrast, the proliferation of all 12 lymphoma lines were inhibited by CpGs. The strongest inhibitory effects were seen with CpG 7909, a class B CpG under clinical development for cancer therapy (Pfizer, PF-3512676). Raji cells were inhibited by 77.9%, 40.7%, and 8.8% at CpG concentrations of 50, 10, and 2 ug/ml, respectively (p≤0.01 for all comparisons vs. media alone). Among the 12 tested cell lines, the percentage growth inhibition using 50 ug/ml CpG 7909 was 61.2-80.4% for germinal center-type DLBCL (SUDHL-4, SUDHL-6, OCI-Ly19), 50-59.5% for activated B cell- type DLBCL (SUDHL-2, OCI-Ly3, OCI-Ly10), 56.4-79.3% for Burkitt's lymphomas (Raji, Ramos, Daudi, BJAB), and 69.6-69.9% for mantle cell lymphomas (Jeko-1, Granta-519). CpG 7909 also induced significant levels of apoptosis in Raji and Jeko-1 cells. Conclusions: We report here for the first time on the ability of CpGs to directly inhibit the proliferation of a large panel of human B-cell lymphomas representing the majority of aggressive histologies. These results provide a novel mechanism of action for CpGs as therapeutic agents for B-cell lymphomas. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer
Case 24-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, L. Jack Faling, Eugene J. Mark
Journal: New England Journal of Medicine (1990)

Case Records of the Massachusetts General Hospital from The New England Journal of Medicine — Case 24-1990 — A 53-Year-Old Middle Eastern Man with Uveitis, Hilar Lymphadenopathy, and Interstitial Lung Disease
Angiographic Demonstration of Intramyocardial Sinusoids in Pulmonary-Valve Atresia with Intact Ventricular Septum and Hypoplastic Right Ventricle
Authors: Ronald M. Lauer, Howard P. Fink, Eugene L. Petry, Marvin I. Dunn, Antoni M. Diehl
Journal: New England Journal of Medicine (1964)

WHEN the semilunar valve is atretic and the ventricular septum is intact the related ventricle must generate unusually high systolic pressures. The only points of egress from such a ventricle are through a regurgitant atrioventricular valve and abnormal intramyocardial sinusoids that lead from the cavity of the ventricle deep into the myocardial wall. These sinusoids have previously been reported in autopsy material in pulmonary-valve atresia with intact ventricular septum by Grant1 and by Williams, Kent and Edwards2 and in aortic atresia with intact ventricular septum by Bellet and Gouley.3 In these pathological studies the abnormal sinusoids were seen to communicate . . .
P273 A retrospective service evaluation of a 2 year cohort, attending a new, dedicated Pulmonary Embolism clinic
Authors: GR Courquin, RM Limbrey
Journal: Thorax (2015)

<h3>Introduction</h3> A service evaluation investigated the effect of follow-up in secondary care on the outcomes of patients who had suffered a Pulmonary Embolism (PE). Patients who attended the PE clinic received a tailored treatment plan specific to their PE event. Events were classified as provoked or unprovoked and their 2 year recurrence rates and complications assessed. <h3>Method</h3> The 2012 cohort of 84 patients from a PE clinic was analysed retrospectively, allowing for a 2 year follow-up. Patients were classified as having sustained a provoked event if a transient provoking risk factor was identified, as per the European Society of Cardiology (ESC) 2014 guidelines. <h3>Results</h3> Of the 84 patients (40 male, 44 female), 83 were available for follow-up at the 2 year mark. Fifty patients (59.5%) had a provoked event whilst 32 (38.1%) were unprovoked- 2 patients had inadequate history to assess. Patients with unprovoked events were investigated further to screen for an underlying malignancy. Three patients (9.38%) were diagnosed with malignancies within 6 months of their PE. Of the unprovoked, 26 underwent a thrombophilia screen with 4 (12.5%) testing positive. Of 83 patients followed to 2 years, 7 (8.4%) had a recurrence (median = 17 months). Two (2.4%) developed chronic thromboembolic pulmonary hypertension whilst 3 (3.6%) developed post-thrombotic syndrome. <h3>Conclusion</h3> Compared to the ESC 2014 guidelines, recurrence rates and complications at 2 years are much lower. The classification of provoked and unprovoked events led to the diagnosis of unknown pathologies. Although only an initial study, this shows that secondary follow-up decreases adverse consequences.