tbuckley/cabot-search huggingface dataset:
FOXM1 Transcription Factor Is a Component of Beta Catenin Signaling in Hematopoietic Progenitors of Chronic Myeloid Leukemia
Authors: Elisa Leo, Giorgia Simonetti, Manuela Mancini, Nevena Veljkovic, Virginia Campi, Fausto Castagnetti, Gabriele Gugliotta, Caterina De Benedittis, Maria Alessandra Santucci, Giovanni Martinelli
Journal: Blood (2014)
Comparison of Efficacy and Safety Results in 103 Treatment-Naïve Acute Myeloid Leukemia (TN-AML) Patients Not Candidates for Intensive Chemotherapy Using 5-Day and 10-Day Regimens of Guadecitabine (SGI-110), a Novel Hypomethylating Agent (HMA)
Authors: Hagop M. Kantarjian, Gail J. Roboz, Patricia L. Kropf, Karen W.L. Yee, Casey L. O'Connell, Raoul Tibes, Katherine J. Walsh, Nikolai A. Podeltsev, Elizabeth A. Griffiths, Elias Jabbour, Guillermo Garcia-Manero, David A. Rizzieri, Wendy Stock, Michael R. Savona, Todd L. Rosenblat, Jesus G. Berdeja, Laksmi Wilson, James N. Lowder, Pietro Taverna, Yong Hao, Mohammad Azab, Jean-Pierre Issa
Journal: Blood (2015)
Management of Chemotherapy‐induced Anemia (CIA) with Biosimilar Epoetin Alfa (Binocrit®) in Patients with Multiple Myeloma (MM): An Interim Analysis of an Ongoing French National Observational Study (The OncoBOS study)
Authors: Irina Voronina, Mario Ojeda-Urib, Charles Dauriac, Laurent Voillat, Camille Aubron-Olivier, Domitille Fernet, Lionel Karlin, Olivier Fitoussi
Journal: Blood (2014)
Eleven-Year Follow-up of Idiotype Vaccine and DA-EPOCH-Rituximab in Untreated Mantle Cell Lymphoma: Correlation of Survival with Idiotype Immune Response
Authors: Cliona Grant, Sattva S. Neelapu, Larry W Kwak, Kieron Dunleavy, Therese White, Barry W. Miller, Elaine S. Jaffe, Seth M. Steinberg, Brian Healey Bird, Wyndham H. Wilson
Journal: Blood (2011)
A Comprehensive Clinical Next Generation Sequencing-Based Assay Can Impact Hematopathologic Diagnosis in a Significant Subset of Patients with Hematologic Malignancies
Authors: Janine D. Pichardo, Julie T Feldstein, Maria Arcila, Connie Batlevi, Andrew D. Zelenetz, Craig H. Moskowitz, Steven M. Horwitz, Martin S. Tallman, Eytan M. Stein, Virginia M. Klimek, Dan Douer, Raajit K. Rampal, Jae H Park, Sergio A Giralt, Jie He, Philip J. Stephens, Vincent Miller, Anas Younes, Ross L. Levine, Ahmet Dogan
Journal: Blood (2014)
Pulmozyme® Treatment of Vectors Produced by Transient Transfection Reduces Residual Plasmid DNA on Human CD34+ Hematopoietic Progenitor Cells without Loss of Transduction or Engraftment Efficiency
Authors: Elke Grassman, Tomoyasu Higashimoto, Justin Rohrbach, Danielle Hall, David A Williams, Lilith Reeves, Punam Malik
Journal: Blood (2008)
Functional Engraftment of Retrovirally Transduced and Pre-Selected Hematopoietic Cells into Partially Ablated Recipient Fabry Mice.
Authors: Jeffrey A. Medin, Sheng-Ben Liang, Armando Poeppl, Makoto Yoshimitsu, Jagdeep S. Walia, Jianhui Cai, Vanessa I. Rasaiah, Daniel H. Fowler
Journal: Blood (2005)
Increased Neutrophil Adhesive Properties In Patients with Venous Thromboembolism and Residual Vein Thrombosis and High D-Dimer Levels
Authors: kiara Cristina Senger Zapponi, Luis Fernando Bittar, Bruna m Mazetto, Fernanda Dutra Santiago-Bassora, Fernanda A. Orsi, Erich V de Paula, Nicola Conran, Joyce M Annichino-Bizzacchi
Journal: Blood (2011)
Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium
Authors: Pilar Brito-Zerón, Nihan Acar-Denizli, Margit Zeher, Astrid Rasmussen, Raphaele Seror, Elke Theander, Xiaomei Li, Chiara Baldini, Jacques-Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Aike A Kruize, Valeria Valim, Marika Kvarnstrom, Damien Sene, Roberto Gerli, Sonja Praprotnik, David Isenberg, Roser Solans, Maureen Rischmueller, Seung-Ki Kwok, Gunnel Nordmark, Yasunori Suzuki, Roberto Giacomelli, Valerie Devauchelle-Pensec, Michele Bombardieri, Benedikt Hofauer, Hendrika Bootsma, Johan G Brun, Guadalupe Fraile, Steven E Carsons, Tamer A Gheita, Jacques Morel, Cristina Vollenveider, Fabiola Atzeni, Soledad Retamozo, Ildiko Fanny Horvath, Kathy Sivils, Thomas Mandl, Pulukool Sandhya, Salvatore De Vita, Jorge Sanchez-Guerrero, Eefje van der Heijden, Virginia Fernandes Moça Trevisani, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals
Journal: Annals of the Rheumatic Diseases (2016)

To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis.The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed.We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African-American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69).This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.
A Novel Mechanism of Action of Bortezomib: Proteasome Inhibition Down-Regulates HLA-Class I on Myeloma and Enhances NK Cell-Mediated Lysis.
Authors: Jumei Shi, Guido J. Tricot, Priyangi A. Malaviarachchi, Tarun K. Garg, Susann M. Szmania, Arend Mulder, John D. Shaughnessy, Bart Barlogie, Frits van Rhee
Journal: Blood (2007)
Comparison of Allogeneic Hematopoietic Stem Cell Transplant from HLA-Matched Related Donors and from Unrelated Donors for Intermediate- to High-Risk Adult Acute Myeloid Leukemia in Remission
Authors: Mingming Zhang, Yi Luo, Xiaoyu Lai, Shoucong Chen, Yamin Tan, Weiyan Zheng, Jimin Shi, Zhen Cai, He Huang
Journal: Blood (2014)
Use of Granulocyte Colony-Stimulating Factor (G-CSF) Together with Induction and Intensification Chemotherapy (CT) in Adults with Primary Acute Myeloid Leukemia (AML).
Authors: Salut Brunet, Granada Perea, Josep M. Ribera, Jordi Esteve, Mar Tormo, Juan Berlanga, Javier Bueno, Andreu Llorente, Jose M. Moraleda, Ramon Guardia, Joan Besalduch, Pio Torres, Maria Paz Queipo de Llano, Josep M. Marti, Carmen Pedro, Joan Bargay, Josep M. Sanchez, Pilar Vivancos, Evaristo Feliu, Emili Montserrat, Jorge Sierra
Journal: Blood (2005)
Autologous Bone Marrow Transplantation for Follicular Lymphoma in First Remission: Long Term Follow up of Two Sequential Trials with Standard Dose and High Dose CHOP Induction.
Authors: Arnold S. Freedman, John G. Gribben, Donna Neuberg, Sigui Li, Helen Kim, Peter Mauch, Lee M. Nadler
Journal: Blood (2004)
SLCO1B1 Variation and Methotrexate Disposition in Children with Acute Lymphoblastic Leukemia: The Importance of Rare Variants in Pharmacogenetics
Authors: Laura B. Ramsey, Gitte H Bruun, Wenjian Yang, Lisa R Trevino, Selina Vattathil, Paul Scheet, Cheng Cheng, Gary Rosner, Kathleen Giacomini, Yiping Fan, Alex Sparreboom, Torben Mikkelsen, Thomas J Corydon, Ching-Hon Pui, William E. Evans, Mary V. Relling
Journal: Blood (2011)
Modulation of Gene Expression Profile and In Vivo Anti-Myeloma Activity Induced by Valproic Acid, a Histone Deacytylase Inhibitor.
Authors: Paola Neri, Teresa Calimeri, Mariateresa Di Martino, Marco Rossi, Orietta Eramo, Mariagrazia Propato, Gino Perri, Antonella Pietragalla, Monica Ventura, Alessandra Bulotta, Simona Blotta, Pierosandro Tagliaferri, Kenneth C. Anderson, Nikhil C. Munshi, Pierfrancesco Tassone
Journal: Blood (2007)
Management of Anemia in Multiple Myeloma Patients Treated with Erythropoiesis Stimulating Agents (ESAs): Findings from the European Anemia Cancer Treatment (A.C.T.) Study
Authors: Heinz Ludwig, Matti Aapro, Carsten Bokemeyer, Pierre Soubeyran, Michael Muenzberg, Matthew Turner, Karen MacDonald, Tara Albrecht, Ivo Abraham
Journal: Blood (2008)
Re-Evaluation of Chronic Graft-Versus-Host Disease Using National Institute of Health Consensus Criteria.
Authors: Dae-Young Kim, Je-Hwan Lee, Jung-Hee Lee, Se Hyung Kim, Sung-nam Lim, Young-Shin Lee, Young-Ah Kang, Sol-Ip Kang, Miee Seol, Seong-Gil Ryu, Kyoo-Hyung Lee
Journal: Blood (2008)
Combined Use of WT1 and Flow Cytometry Monitoring Can Promote Sensitivity of Predicting Relapse After Allogeneic HSCT without Affecting Specificity.
Authors: Xiaosu Zhao, Chenhua Yan, Daihong Liu, Lanping Xu, Yanrong Liu, Kaiyan Liu, Yazhen Qin, Yu Wang, Xiaojun Huang
Journal: Blood (2012)
Antigen-dependent competition shapes the local repertoire of tissue-resident memory CD8+ T cells
Authors: Andreas Muschaweckh, Veit R. Buchholz, Anne Fellenzer, Christian Hessel, Paul-Albert König, Sha Tao, Ronny Tao, Mathias Heikenwälder, Dirk H. Busch, Thomas Korn, Wolfgang Kastenmüller, Ingo Drexler, Georg Gasteiger
Journal: The Journal of Experimental Medicine (2016)

Tissue-resident memory CD8+ T cells (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs. Local, noncognate factors are both necessary and sufficient to support the programming of TRM cell fate in tissue-infiltrating T cells. Recent evidence suggests that TCR signals received in infected nonlymphoid tissues additionally contribute to TRM cell formation. Here, we asked how antigen-dependent pathways influence the generation of skin-resident memory T cells that arise from a polyclonal repertoire of cells induced by infection with an antigenically complex virus and recombinant vaccine vector. We found that CD8+ T cells of different specificities underwent antigen-dependent competition in the infected tissue, which shaped the composition of the local pool of TRM cells. This local cross-competition was active for T cells recognizing antigens that are coexpressed by infected cells. In contrast, TRM cell development remained largely undisturbed by the presence of potential competitors when antigens expressed in the same tissue were segregated through infection with antigenically distinct viral quasispecies. Functionally, local cross-competition might serve as a gatekeeping mechanism to regulate access to the resident memory niche and to fine-tune the local repertoire of antiviral TRM cells.
Improved Efficacy Upon Combined JAK1/2 and Pan-Deacetylase Inhibition Using Ruxolitinib (INC424) and Panobinostat (LBH589) in Preclinical Mouse Models of JAK2V617F-Driven Disease
Authors: Fabienne Baffert, Emeline Evrot, Nicolas Ebel, Claudia Roelli, Rita Andraos, Zhiyan Qian, Vincent Romanet, Masato Murakami, Thomas Radimerski
Journal: Blood (2011)
Krüppel-like Factor 4 (KLF4) Suppresses T-Cell Acute Lymphoblastic Leukemia By Inhibiting Expression of MAP2K7 and Expansion of Leukemia Initiating Cells
Authors: Ye Shen, Chun Shik Park, Koramit Suppipat, Takeshi Yamada, Toni-Ann Mistretta, Daniel Lacorazza
Journal: Blood (2014)
We need clear health messages about exercise
Authors: David Hupin, Pascal Edouard, Vincent Gremaux, Frédéric Roche, Jean-Claude Barthélémy
Journal: BMJ (2016)

Simplifying health messages can be puzzling. French media1 recently criticised WHO’s 2016 physical activity recommendations,2 based on the data published by Kyu and colleagues in The BMJ .3 Two years ago, they ran a very different headline: “Sitting kills more people than tobacco,” based on a commentary published in 2009.4

The …
Impact of Granulocyte Colony-Stimulating Factor during Induction Therapy in Children with Acute Myelogenous Leukemia: Results from the Prospective and Randomized Trial AML-BFM 98.
Authors: Thomas Lehrnbecher, Martin Zimmermann, Dirk Reinhardt, Michael Dworzak, Jan Stary, Ursula Creutzig
Journal: Blood (2004)
FoxO Transcription Factor Is Delocalized in CML Patients by Bcr-Abl Induced PI3K/AKT Activation and IKK Pathway and Can Be Reactivated by Imatinib Treatment.
Authors: Daniela Cilloni, Cristina Panuzzo, Francesca Messa, Francesca Arruga, Paolo Nicoli, Emanuela Messa, Stefano Ulisciani, Ilaria Iacobucci, Giovanni Martinelli, Enrico Bracco, Thea Kalebic, Giuseppe Saglio
Journal: Blood (2007)
Being the Pioneer of Life Sciences in China
Authors: Xin Zhang
Journal: Genomics Proteomics & Bioinformatics (2004)

has presented significant contributions to the development of life sciences in China by its excellent scientific innovations and achievements in the last five years.From the participation of International Human Genome Project (HGP) to the independent completion of the wholegenome draft and fine maps of Chinese super hybrid rice genome, from the porcine genome research cooperated with Denmark to the international chicken genome research, and from the silkworm genome project accomplished together with The Southwest Agriculture University of China to the great contributions to the national campaign against SARS, all these facts illustrate that BGI not only has a first-class scientific research power in the world but also is full of devotion to the flourish of science and nation.During these years, we have upheld the strategy of "Advance through projects, strive for innovation, grow through cooperation", in the aim of making
Adenosine A2A and Beta-2 Adrenergic Receptor Agonist Synergy in B-Cell Malignancies: Selectivity, Breadth of Activity and Effects of Chronic Exposure.
Authors: Richard J. Rickles, Winnie F. Tam, Antoaneta Necheva, Thomas Giordano, Alexis A. Borisy, Margaret S. Lee
Journal: Blood (2009)
Compared Molecular Monitoring of BCR-ABL Transcripts in Peripheral Blood and Bone Marrow Samples in CML Patients after Allogeneic Hematopoiteic Stem Cell Transplant.
Authors: Alida Dominietto, Gabriella Cirmena, Anna Garuti, Anna Maria Raiola, Adalberto Ibatici, Maria Teresa van Lint, Francesco Frassoni, Andrea Bacigalupo
Journal: Blood (2006)
Response to: ‘Let's not fool ourselves. In RA, the ACR/EULAR remission criteria are not perfect!’ by Baker <i>et al</i>
Authors: Maarten Boers
Journal: Annals of the Rheumatic Diseases (2016)

Baker et al 1 raise many interesting points on the validity and use of the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria that I would like to reflect on.

But first of all I would like to reiterate my main point, one which I think we agree on:

In all clinical trials where remission is one of the outcomes, it should be defined according to the ACR/EULAR criteria.

Baker et al list several concerns on these criteria that are well taken, and some that are generic to the way we measure disease activity today.

Indeed, the ACR/EULAR criteria were developed with the express aim to define remission, more specifically ‘to develop a definition of remission that is stringent but achievable and could be applied uniformly as an outcome measure in clinical trials’. Although the committee was …
Dendritic Cell-Induced T Cell Non-Responsiveness Is Mediated by FOXP3+ and TGF-beta+IL-10+ CD4+ T Cells.
Authors: Zwi N. Berneman, Nathalie Cools, Viggo F.I. Van Tendeloo, Marc Lenjou, Griet Nijs, Dirk R. Van Bockstaele, Peter Ponsaerts
Journal: Blood (2006)
Overdiagnosis of thyroid cancer
Authors: Louise Davies
Journal: BMJ (2016)

Non-lethal cancers picked up by screening are probably responsible 

Thyroid cancer incidence has increased dramatically in many countries in the developed world over the past three decades.1 Papillary thyroid cancer, which has been responsible for virtually the entire increase, is rarely lethal. The 20 year survival rate is greater than 90%, and approaches 100% for the smallest cancers.2 The increasing incidence is most likely due to overdiagnosis—the detection of subclinical cancers never destined to cause harm.3 4 This conclusion has been reached because the incidence has been primarily due to the detection of small papillary cancers, mortality due to thyroid cancer has not changed significantly, and small foci of papillary thyroid cancer are commonly found at autopsy in people who died of other causes. Overdiagnosis is a problem because it exposes people to the potential side effects of treatment, but without an equal expectation of benefit, because the cancer is unlikely to advance.

In a linked article in The BMJ ,5 Park and colleagues extend our understanding of the issue in South Korea, which has seen a 15-fold increase in incidence over the past 10 years,6 …
Loss Of IKZF1 Function Mediates Resistance Towards Glucocorticoid-Induced Apoptosis
Authors: Jorn Havinga, Laurensia Yuniati, Marc Demkes, Dorette van Ingen Schenau, Roland P. Kuiper, Peter M. Hoogerbrugge, Frank N. van Leeuwen, Blanca Scheijen
Journal: Blood (2013)
E-Selectin Ligand Expression Increases with Progression of Myeloma and Induces Drug Resistance in a Murine Transplant Model, Which Is Overcome By the Glycomimetic E-Selectin Antagonist, GMI-1271
Authors: Alessandro Natoni, Theodore A.G. Smith, Niamh Keane, Silvia C. Locatelli-Hoops, Isabela Oliva, William E. Fogler, John L. Magnani, Michael O'Dwyer
Journal: Blood (2015)
Treatment Results of Intensive Chemotherapy for Higher-Risk Myelodysplastic Syndrome (HR-MDS) and Acute Myeloid Leukemia Related to MDS (MDS-AML)
Authors: Taiichi Kyo, Noriaki Yoshida, Kouhei Kyo, Takeshi Okatani, Mitsuhiro Itagaki, Hiromi Yuasa, Koji Iwato, Hideki Asaoku, Yuuta Katayama
Journal: Blood (2010)
In Vitro and in Vivo oncolytic Activity of Lasota Strain of Newcastle Disease Virus on a Lymphoma B-Cell Line and a Canine Cutaneous T-Cell Lymphoma
Authors: Diana Sanchez., Rosana Pelayo, Rosa Elena Sarmiento, Luis Alberto Medina, Gabriela N. Cesarman-Maus, Luis Nuñez, Nicolle Carrillo, Jose de Jesus Paredes, Hortencia Corona, Eduardo Vadillo
Journal: Blood (2014)
Expression of Erythropoietin and Erythropoietin Receptor in Squamous Cell Carcinomas of the Head and Neck: Levels of Erythropoietin Expression Correlate with Tumor Hypoxia.
Authors: Murat O. Arcasoy, Khalid Amin, Shu-Chuan Chou, Zishan A. Haroon, Mahesh Varia, James A. Raleigh
Journal: Blood (2004)
Low Toxicity and Mortality with Reversed-Order Conditioning (Cyclophosphamide Followed by Targeted Intravenous Busulfan) in Allogeneic Hematopoietic Cell Transplantation: Preliminary Results of a Prospective Clinical Trial.
Authors: Andrew R. Rezvani, Jeannine S. McCune, Ami Batchelder, Barry E. Storer, George B. McDonald, H. Joachim Deeg
Journal: Blood (2009)
High Risk Pregnancies in Women with Diamond Blackfan Anaemia: A Survey of 64 Pregnancies from the French and German Registries.
Authors: Thierry Leblanc, Laurence Faivre, Jorg Meerpohl, Lydie Da Costa, Christian Nouvel, Francis Bauters, Bertrand Coiffier, Pierre-Yves Peaud, Patrick Rispal, Alain Berrebi, Claire Berger, Bruno Varet, Charlotte Niemeyer, Gil Tchernia
Journal: Blood (2005)
Methylation of the Proximal Promoter of GADD45A Is Common in Acute Myeloid Leukemia and Is Associated with Poor Survival.
Authors: Richard J D'Andrea, Michelle Perugini, Sonya M Diakiw, Chung H Kok, Diana Salerno, Nik Cummings, Anna L Brown, Silke Danner, Peter G Bardy, Andrew H Wei, L. Bik To, Ian D Lewis
Journal: Blood (2012)
Thalidomide/Dexamethasone (TD) Vs. Bortezomib(Velcade®)/Thalidomide/Dexamethasone (VTD) Vs. VBMCP/VBAD/Velcade® As Induction Regimens Prior Autologous Stem Cell Transplantation (ASCT) in Younger Patients with Multiple Myeloma (MM): First Results of a Prospective Phase III PETHEMA/Gem Trial
Authors: Laura Rosinol, M. Teresa Cibeira, Joaquin Martinez, Maria Victoria Mateos, Ma José Terol, Javier de la Rubia, Luis Palomera, Felipe de Arriba, Albert Oriol, Adrian Alegre, Juan Besalduch, Raquel de Paz, José Garcia-Laraña, Joaquín Díaz-Mediavilla, Anna Sureda, Juan José Lahuerta, J.F. San Miguel, Joan Blade
Journal: Blood (2008)
Trend Analysis of 5-Year All-Cause Mortality After Autologous Stem Cell Transplantation in Patients with Lymphoma and Multiple Myeloma
Authors: Mojtaba Akhtari, James O. Armitage, Philip Bierman, R. Gregory Bociek, Edward Anthony Faber, Lori Maness, Julie M Vose, Fausto R. Loberiza
Journal: Blood (2011)
Erythropoietin Mediated Increase in Monocyte-Derived Liver Macrophages; A Role for Kupffer Cells?
Authors: Dafna Gilboa, Yasmin Haim-Ohana, Nathali Ben-Califa, Naamit Deshet-Unger, Sahar Bab-Hiram, Max Gassmann, Moshe Mittelman, Drorit Neumann
Journal: Blood (2015)
Phase II Pilot Study of Gemtuzumab Ozogamicin (GO), Fludarabine, Cytarabine and Idarubicin Combined Regimen as Induction Therapy Plus GO Alone as Consolidation Therapy for Elderly Acute Myeloid Leukemia Patients.
Authors: Maria Teresa Pirrotta, Monica Bocchia, Alessandro Bucalossi, Marzia Defina, Francesco Forconi, Simona Sammassimo, Francesco Lauria
Journal: Blood (2005)
Point Mutations In Myelodysplastic Syndromes Are Associated with Clinical Features and Are Independent Predictors of Overall Survival
Authors: Rafael Bejar, Kristen Stevenson, Omar Abdel-Wahab, McConkey Marie, Katherine Lin, James Randall McAuley, Kevin Cheung, Naomi Galili, Guillermo Garcia-Manero, Hagop Kantarjian, Azra Raza, Ross Levine, Donna Neuberg, Benjamin L. Ebert
Journal: Blood (2010)
UGT1A1*28 polymorphism and vomiting in advanced colorectal cancer.
Authors: Ahmed El Saied El Bastawisy, Amany El-Zeiny, Samar Farid, Abeer Bahnasy
Journal: Journal of Clinical Oncology (2013)

e14678 Background: UGT1A1*28 polymorphism is associated with neutropenia and diarrhea in previous reports, this study tried to investigate correlation with other toxicities like vomiting. Methods: This is a prospective case control study including all eligible cases of advanced colorectal cancer. The genotypes of UGT1A1*28 was assessed in the peripheral blood and/or in tissues by PCR. Patients were divided into two groups, group1: patients with no or hetero mutation, group 2: patients with homo mutation. All patients received standard IFL regimen. Primary endpoints were: 1-comparison between the 2 groups as regard vomiting .2-assessement of the incidence of UGT1A1*28 polymorphism. Secondary endpoints were: comparison between the 2 groups as regard: neutropenia, diarrhea, progressive diseases (PD), progression free survival (PFS) and overall survival (OS). Results: 43 cases of advanced colorectal cancer aged between 19 and 68 years with a median age of 45 years were included and followed up during the period from September 2010 to January 2013 with a median follow up of 9 months. UGT1A1*28 polymorphism were present in 21 patients (42%) of them 14% are homozygous. Grade (II-III) vomiting was found in 18.9% of group 1 versus 66.7% of group2. (P=0.03).Grade (II-IV) neutropenia were found in 27% of group 1 versus 83.4% of group2. (P=0.01). Grade (II-III) diarrhea was found in 37.8% of patients of group1 and 16.7% of patients with group 2. (P=0.44).20% of group 1 showed PD versus 40% of group 2. (P=0.5).1year PFS was 19% in group 1 versus 0% in group 2. (P= 0.74) while there was a trend towards better OS in group 1 (47% versus 0%). (P= 0.0892). Conclusions: UGT1A1*28 polymorphism is present frequently (42%) in a Caucasian population and is associated with more vomiting and neutropenia.
A Recombinant Antibody to EphA3 for the Treatment of Hematologic Malignancies: Research Update and Interim Phase 1 Study Results
Authors: Anne Hagey, Jeffrey E. Lancet, Varghese Palath, Andrew H Wei, Martin Lackmann, Jorge E. Cortes, Andrew Boyd, Dan Shochat, Geoffrey Yarranton, Christopher Bebbington, Jonathan A. Leff
Journal: Blood (2011)