tbuckley/cabot-search huggingface dataset:
Long-Term Biased β-Arrestin Signaling Improves Cardiac Structure and Function in Dilated Cardiomyopathy
Authors: David M. Ryba, Jieli Li, Conrad L. Cowan, Brenda Russell, Beata M. Wolska, R. John Solaro
Journal: Circulation (2017)

Biased agonism of the angiotensin II receptor is known to promote cardiac contractility. Our laboratory indicated that these effects may be attributable to changes at the level of the myofilaments. However, these signaling mechanisms remain unknown. Because a common finding in dilated cardiomyopathy is a reduction in the myofilament-Ca2+ response, we hypothesized that β-arrestin signaling would increase myofilament-Ca2+ responsiveness in a model of familial dilated cardiomyopathy and improve cardiac function and morphology.We treated a dilated cardiomyopathy-linked mouse model expressing a mutant tropomyosin (Tm-E54K) for 3 months with either TRV120067, a β-arrestin 2-biased ligand of the angiotensin II receptor, or losartan, an angiotensin II receptor blocker. At the end of the treatment protocol, we assessed cardiac function using echocardiography, the myofilament-Ca2+ response of detergent-extracted fiber bundles, and used proteomic approaches to understand changes in posttranslational modifications of proteins that may explain functional changes. We also assessed signaling pathways altered in vivo and by using isolated myocytes.TRV120067- treated Tm-E54K mice showed improved cardiac structure and function, whereas losartan-treated mice had no improvement. Myofilaments of TRV120067-treated Tm-E54K mice had significantly improved myofilament-Ca2+ responsiveness, which was depressed in untreated Tm-E54K mice. We attributed these changes to increased MLC2v and MYPT1/2 phosphorylation seen only in TRV120067-treated mice. We found that the functional changes were attributable to an activation of ERK1/2-RSK3 signaling, mediated through β-arrestin, which may have a novel role in increasing MLC2v phosphorylation through a previously unrecognized interaction of β-arrestin localized to the sarcomere.Long-term β-arrestin 2-biased agonism of the angiotensin II receptor may be a viable approach to the treatment of dilated cardiomyopathy by not only preventing maladaptive signaling, but also improving cardiac function by altering the myofilament-Ca2+ response via β-arrestin signaling pathways.
Overuse of DVT Prophylaxis in Medical Inpatients
Authors: Jing Deng, Lisa Thomas, Huijing Li, Elvin Varughesekutty, Qi Shi, Meenakshi Sambharia, Kevin Musto, Gaurav Petal, Erin Gordon, Sudeep Ruparella, Rajiv Bansal
Journal: Blood (2015)
Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma
Authors: Wanda Phipatanakul, David T. Mauger, Ronald L. Sorkness, Jonathan M. Gaffin, Fernando Holguin, Prescott G. Woodruff, Ngoc P. Ly, Leonard B. Bacharier, Nirav R. Bhakta, Wendy C. Moore, Eugene R. Bleecker, Annette T. Hastie, Deborah A. Meyers, Mario Castro, John V. Fahy, Anne M. Fitzpatrick, Benjamin M. Gaston, Nizar N. Jarjour, Bruce D. Levy, Stephen P. Peters, W. Gerald Teague, Merritt Fajt, Sally E. Wenzel, Serpil C. Erzurum, Elliot Israel
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Phenotypic distinctions between severe asthma (SA) and nonsevere asthma (NONSA) may be confounded by differential adherence or incorrect use of corticosteroids.
Genetic characterisation of novel, highly pathogenic avian influenza (HPAI) H5N6 viruses isolated in birds, South Korea, November 2016
Authors: Young-Jae Si, In Won Lee, Eun-Ha Kim, Young-Il Kim, Hyeok-Il Kwon, Su-Jin Park, Hiep Dinh Nguyen, Se Mi Kim, Jin-Jung Kwon, Won-Suk Choi, Yun Hee Beak, Min-Suk Song, Chul-Joong Kim, Richard J. Webby, Young-Ki Choi
Journal: Eurosurveillance (2017)

A novel genotype of H5N6 influenza viruses was isolated from migratory birds in South Korea during November 2016. Domestic outbreaks of this virus were associated with die-offs of wild birds near reported poultry cases in Chungbuk province, central South Korea. Genetic analysis and animal studies demonstrated that the Korean H5N6 viruses are highly pathogenic avian influenza (HPAI) viruses and that these viruses are novel reassortants of at least three different subtypes (H5N6, H4N2 and H1N1).
Risk of Childhood Asthma Following Infant Bronchiolitis During RSV Season
Authors: K.M. James, T. Gebretsadik, G.J. Escobar, P. Wu, K.N. Carroll, S.X. Li, E.M. Walsh, E.F. Mitchel, C. Sloan, T.V. Hartert
Journal: Journal of Allergy and Clinical Immunology (2012)
Biofunctionalization of Nerve Interface via Biocompatible Polymer‐Roughened Pt Black on Cuff Electrode for Chronic Recording
Authors: Yi Jae Lee, Han‐Jun Kim, Ji Yoon Kang, Sun Hee Do, Soo Hyun Lee
Journal: Advanced Healthcare Materials (2017)

Peripheral nerve cuff electrodes with roughened Pt black (BPt) are coated with polyethylene glycol (PEG) and Nafion (NF). Although the influence of coated PEG and Nafion on roughened BPt on the electrical properties is weak, the cuff electrode with BPt/PEG and BPt/Nafion exhibits some very important properties. For example, it markedly decreases interfacial impedance, increases charge storage capacity (CSC) due to retaining the BPt surface structure, good stability without exfoliation in repetitive cyclic voltammetry scanning because it is protected by PEG or Nafion coating. In cell viability test, Nafion‐coated BPt does not show cytotoxicity to rat Schwann cell line (S16) at 24 and 72 h with the Nafion coating ranging from 0.1 to 10 mg cm −2 . In addition, real‐time polymerase chain reaction (PCR) analysis indicates that Schwann cell differentiation (S100 calcium‐binding protein B, myelin basic protein, peripheral myelin protein 22), proliferation (proliferating cell nuclear antigen, cyclin‐dependent kinase 1 (CDK1)), and adhesion molecules (neural cell adhesion molecule, laminin, fibronectin) are upregulated up to 5 mg cm −2 of Nafion. In animal study, the BPt/Nafion reduces infiltration of fibrotic tissue with high axonal maintenance with upregulation of proliferation (CDK1), adhesion (laminin, neuronal cell adhesion molecule), and neurotrophic factor receptor‐related (gdnf family receptor alpha 1) mRNA expressions.
Interleukin-21 Induces Cell Cycle Arrest and Apoptosis of Diffuse Large B-Cell Lymphomas (DLBCL) Via Activation of STAT3 and Upregulation of C-Myc
Authors: Kristopher A Sarosiek, Hovav Nechushtan, Eli Avisar, Izidore S Lossos
Journal: Blood (2008)
Abstract 12178: Non-contrast T1 Mapping Detects Myocardial Edema in Patients With Takotsubo Cardiomyopathy
Authors: Yukio Aikawa, Teruo Noguchi, Yoshiaki Morita, Yoichi Goto, Hisao Ogawa, Satoshi Yasuda
Journal: Circulation (2015)

Background: Although early gadolinium enhancement (EGE) and T2-weighted image (T2WI) can detect myocardial edema in patients with Takotsubo cardiomyopathy (TCM), the clinical significance of non-contrast T1 mapping remains unclear. Methods: Cardiac magnetic resonance at 3T was performed in consecutive 11 patients with TCM. Non-contrast T1 mapping using T1 relaxation time was evaluated. The EGE phase was defined as 2 minutes after gadolinium administration. Results: EGE and high-signal intensity on T2WI were detected at apical ballooning area in all patients (Figure1A, yellow arrows), whereas no late gadolinium enhancement (LGE) was observed. Non-contrast T1 relaxation time in apical region was significantly higher than that in remote myocardium (1510±131 vs. 1291±65 msec, p&lt;0.001) (Figure 1A, green arrows). Non-contrast T1 relaxation time correlated significantly with Extra Cellular Volume (r = 0.793, p = 0.0004) (Figure 1B). Conclusion: Non-contrast T1 mapping can detect myocardial edema and may differentiate reversible myocardial damage from normal myocardium in TCM.
ISWI Chromatin Remodeling ATPase Smarca5 (Snf2h) Is Required for Murine Erythroid Development and Globin Gene Regulation
Authors: Juraj Kokavec, Romit Majumdar, Martina Kapalova, Nikola Curik, Filipp Savvulidi, Emanuel Necas, Arthur I. Skoultchi, Tomas Stopka
Journal: Blood (2010)
Poor Adherence to Ketone Testing in Patients With Type 1 Diabetes
Authors: Anastasia Albanese-O’Neill, Mengdi Wu, Kellee M. Miller, Laura Jacobsen, Michael J. Haller, Desmond Schatz
Journal: Diabetes Care (2017)

Diabetic ketoacidosis (DKA) is an acute, still common, and preventable complication of type 1 diabetes (T1D) associated with increased health care costs, morbidity, and mortality (1,2). Clinical recommendations advise self-monitoring of ketones in people with T1D during hyperglycemia and illness to allow for early diagnosis of ketonemia or ketonuria and to reduce the risk of DKA (3,4). The potential benefits of self-monitoring of ketones can only be realized if ketone monitoring and management are conducted as advised. The purpose of this study was to characterize ketone monitoring behaviors in both children and adults with T1D who completed an online questionnaire during October and November 2015 as part of the T1D Exchange Clinic Registry.

Participants were asked a number of questions about ketone …
No evidence for the use of stem cell therapy for tendon disorders: a systematic review
Authors: Haiko I M F L Pas, Maarten H Moen, Hidde J Haisma, Marinus Winters
Journal: British Journal of Sports Medicine (2017)

Introduction Stem cells have emerged as a new treatment option for tendon disorders. We systematically reviewed the current evidence for stem cell therapy in tendon disorders. Methods Randomised and non-randomised controlled trials, cohort studies and case series with a minimum of 5 cases were searched in MEDLINE, CENTRAL, EMBASE, CINAHL, PEDro and SPORTDiscus. In addition, we searched grey literature databases and trial registers. Only human studies were included and no time or language restrictions were applied to our search. All references of included trials were checked for possibly eligible trials. Risk of bias assessment was performed using the Cochrane risk of bias tool for controlled trials and the Newcastle-Ottawa scale for case series. Levels of evidence were assigned according to the Oxford levels of evidence. Results 4 published and three unpublished/pending trials were found with a total of 79 patients. No unpublished data were available. Two trials evaluated bone marrow-derived stem cells in rotator cuff repair surgery and found lower retear rates compared with historical controls or the literature. One trial used allogenic adipose-derived stem cells to treat lateral epicondylar tendinopathy. Improved Mayo Elbow Performance Index, Visual Analogue Pain scale and ultrasound findings after 1-year follow-up compared with baseline were found. Bone marrow-derived stem cell-treated patellar tendinopathy showed improved International Knee Documentation Committee, Knee injury and Osteoarthritis Outcome Score subscales and Tegner scores after 5-year follow-up. One trial reported adverse events and found them to be mild (eg, swelling, effusion). All trials were at high risk of bias and only level 4 evidence was available. Conclusions No evidence (level 4) was found for the therapeutic use of stem cells for tendon disorders. The use of stem cell therapy for tendon disorders in clinical practice is currently not advised.
Results of a Phase 1 Dose-Escalation Study of Once-Weekly MLN9708, an Investigational Proteasome Inhibitor, in Patients with Relapsed/Refractory Lymphoma
Authors: Sarit Assouline, Julie E. Chang, Bruce D. Cheson, Robert Rifkin, Solomon Hamburg, Ruben Reyes, Ai-Min Hui, Jiang Yu, Neeraj Gupta, Alessandra Di Bacco, Yaping Shou, Peter Martin
Journal: Blood (2012)
The Contact with MDS Endothelial Cells Alters the Pattern of Lineage-Specific Gene Expression During Normal Hematopoietic Differentiation
Authors: Luciana Teofili, Eugenia Rosa Nuzzolo, Maurizio Martini, Maria Teresa Voso, Sara Capodimonti, Valeriana Cocomazzi, Maria Grazia Iachininoto, Gina Zini, Luigi M. Larocca
Journal: Blood (2012)
BCL6 Dose Not Negatively Regulate DNA Damage Response Genes in Multiple Myeloma Cells
Authors: Kenichi Tahara, Makiko Takizawa, Hiroshi Handa, Yuta Masuda, Ayaka Kaneko, Itsumi Suda, Kei Kimura, Yuko Kuroda, Isoda Atsushi, Morio Matsumoto, Hiromi Koiso, Ishizaki Takuma, Takeki Mitsui, Akihiko Yokohama, Takayuki Saitoh, Norifumi Tsukamoto, Hirokazu Murakami
Journal: Blood (2014)
Larger Number of Invariant Natural Killer T-Cells in Allogeneic Peripheral Blood Stem Cell Grafts Is Associated with Improved Graft-Versus-Host Disease-Free, Progression-Free Survival after Allogeneic Stem Cell Transplantation
Authors: Florent Malard, Myriam Labopin, Patrice Chevallier, Thierry Guillaume, Alix Duquesne, Sophie Derenne, Eolia Brissot, Marc Gregoire, Philippe Moreau, Philippe Saas, Mohamad Mohty, Bbéatrice Gaugler
Journal: Blood (2015)
An approach to hypopigmentation
Authors: Jeremy P Hill, Jonathan M Batchelor
Journal: BMJ (2017)

#### What you need to know

Around 1 in 20 people have at least one hypopigmented macule.1 Patients may worry about pale patches and links to other disease. Hypopigmentation can be upsetting, particularly if visible. For people with darker skin, hypopigmentation may also result in stigma.2 Most causes of hypopigmentation are not serious, can be diagnosed clinically and may be treatable. This article aims to help non-specialists assess and treat patients with hypopigmented patches, focusing on the commonest conditions and mentioning rarer but important conditions where specialist referral may be necessary.

Consider demographics:

Ask the patient to describe how the pale patch began, how it has developed and whether there are any other patches. Discuss the impact that the condition is having on the patient’s self confidence and on wider aspects of …
Concurrent Follicular Lymphoma At Diagnosis Has a Negative Impact On The Outcome Of Patients With Diffuse Large B Cell Lymphoma
Authors: David Wrench, Hasan Rizvi, Andrew Wilson, Ciaran O'Riain, Andrew Clear, Janet Matthews, Daniele Laszlo, T. Andrew Lister, John G. Gribben, Maria Calaminici, Silvia Montoto
Journal: Blood (2013)
Frequent Mutation of the PIK3CA Gene in Saudi Arabian Diffuse Large B-Cell Lymphoma.
Authors: Jehad A. Abubaker, Prashant P. Bavi, Sayer Al-Harbi, Valerie L. Atizado, Fouad Al-Dayel, Adnan Ezzat, Shahab Uddin, Khawla S. Al-Kuraya
Journal: Blood (2006)
Prevalence of Perceived Food and Housing Security — 15 States, 2013
Authors: Rashid Njai, Paul Siegel, Shaoman Yin, Youlian Liao
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Recent global (1) and national (2,3) health equity initiatives conclude that the elimination of health disparities requires improved understanding of social context (4,5) and ability to measure social determinants of health, including food and housing security (3). Food and housing security reflect the availability of and access to essential resources needed to lead a healthy life. The 2013 Behavioral Risk Factor Surveillance System (BRFSS) included two questions to assess perceived food and housing security in 15 states.* Among 95,665 respondents, the proportion who answered "never or rarely" to the question "how often in the past 12 months would you say you were worried or stressed about having enough money to buy nutritious meals?" ranged from 68.5% to 82.4% by state. Among 90,291 respondents living in housing they either owned or rented, the proportion who answered "never or rarely" to the question, "how often in the past 12 months would you say you were worried or stressed about having enough money to pay your rent/mortgage?" ranged from 59.9% to 72.8% by state. Food security was reported less often among non-Hispanic blacks (blacks) (68.5%) and Hispanics (64.6%) than non-Hispanic whites (whites) (81.8%). These racial/ethnic disparities were present across all levels of education; housing security followed a similar pattern. These results highlight racial/ethnic disparities in two important social determinants of health, food and housing security, as well as a substantial prevalence of worry or stress about food or housing among all subgroups in the United States. The concise nature of the BRFSS Social Context Module's single-question format for food and housing security makes it possible to incorporate these questions into large health surveys so that social determinants can be monitored at the state and national levels and populations at risk can be identified.
433 THE ACTIVE METABOLITE OF LEFLUNOMIDE, A77 1726, PROTECTS RAT HEPATOCYTES AGAINST BILE ACID-INDUCED APOPTOSIS
Authors: T.E. Vrenken, A.J. Kalsbeek, M. Buist-Homan, K.N. Faber, H. Moshage
Journal: Journal of Hepatology (2008)
The Significance of Complete Clearance of Peripheral Blasts after 7 Days of Prednisolone in Children with Acute Lymphoblastic Leukemia: Tokyo Children’s Cancer Study Group (TCCSG) Study L99-15.
Authors: Katsuyoshi Koh, Akira Ohara, Atsushi Manabe, Kouichiro Ikuta, Ryouji Hanada, Hiromasa Yabe, Akitoshi Kinoshita, Kenichi Koike, Yuri Okimoto, Yasushi Noguchi, Michiko Kajiwara, Hiroyuki Takahashi, Kanji Sugita, Takashi Fukushima, Keiichi Isoyama, Masahiro Saito, Akira Kikuchi, Setsuo Ota, Masaaki Kumagai, Yasuhide Hayashi, Tomohiro Saito, Masahiro Tsuchida
Journal: Blood (2006)
Comparison of steady-state imatinib (IM) trough levels, clinical response, and safety between Caucasian and Asian patients with chronic myeloid leukemia in chronic phase (CML-CP) treated with 400mg and 800mg daily doses of IM in the tyrosine kinase inhibi
Authors: Dong-Wook Kim, Camille Granvil, Eren Demirhan, John Reynolds, Yu Jin, Yanfeng Wang, Michele Baccarani, Jorge Cortes-Franco, Brian J. Druker, Timothy P. Hughes, Francois Guilhot
Journal: Blood (2009)
High Levels of Soluble Immunoregulatory Receptors in Patients with WaldenströM’s Macroglobulinemia.
Authors: Zachary R. Hunter, Andrew R. Branagan, Daniel Ditzel Santos, Olivier Tournilhac, Evdoxia Hatjiharissi, Lian Xu, Robert J. Manning, Steven P. Treon
Journal: Blood (2004)
Mesenchymal Fetal Stem Cells (FMSC) from Amniotic Fluid (AF): Expansion and Phenotypic Characterization
Authors: Maria Concetta Renda, Emanuela Fecarotta, Giovanna Schillaci, Filippo Leto, Giuseppina Calvaruso, Giuseppa Maria Garofalo, Angela Piazza, Massimiliano Sacco, Rosario Di Maggio, Angela Vitrano, Aurelio Maggio
Journal: Blood (2015)
Similar Survival, but Better Quality of Life After Myeloablative Transplantation Using Unrelated Cord Blood Versus Identical Sibling Hematopoietic Cells in Adults with Hematologic Malignancies: A Single Institute Analysis.
Authors: Huilan Liu, Liangquan Geng, Xingbing Wang, Kaiyang Ding, Juan Tong, Baolin Tang, Chenyang Zhou, Yun Wu, Wen Yao, Changcheng Zheng, Xin Liu, Weibo Zhu, Zhuyi Wang, Zimin Sun
Journal: Blood (2012)
Deficient retinoid-driven angiogenesis may contribute to failure of adult human lung regeneration in emphysema
Authors: John-Poul Ng-Blichfeldt, Joana Alçada, M Angeles Montero, Charlotte H Dean, Uta Griesenbach, Mark J Griffiths, Matthew Hind
Journal: Thorax (2017)

<h3>Background</h3> Molecular pathways that regulate alveolar development and adult repair represent potential therapeutic targets for emphysema. Signalling via retinoic acid (RA), derived from vitamin A, is required for mammalian alveologenesis, and exogenous RA can induce alveolar regeneration in rodents. Little is known about RA signalling in the human lung and its potential role in lung disease. <h3>Objectives</h3> To examine regulation of human alveolar epithelial and endothelial repair by RA, and characterise RA signalling in human emphysema. <h3>Methods</h3> The role of RA signalling in alveolar epithelial repair was investigated with a scratch assay using an alveolar cell line (A549) and primary human alveolar type 2 (AT2) cells from resected lung, and the role in angiogenesis using a tube formation assay with human lung microvascular endothelial cells (HLMVEC). Localisation of RA synthetic (RALDH-1) and degrading (cytochrome P450 subfamily 26 A1 (CYP26A1)) enzymes in human lung was determined by immunofluorescence. Regulation of RA pathway components was investigated in emphysematous and control human lung tissue by quantitative real-time PCR and Western analysis. <h3>Results</h3> RA stimulated HLMVEC angiogenesis in vitro; this was partially reproduced with a RAR-α agonist. RA induced mRNA expression of vascular endothelial growth factor A (VEGFA) and VEGFR2. RA did not modulate AT2 repair. CYP26A1 protein was identified in human lung microvasculature, whereas RALDH-1 partially co-localised with vimentin-positive fibroblasts. CYP26A1 mRNA and protein were increased in emphysema. <h3>Conclusions</h3> RA regulates lung microvascular angiogenesis; the endothelium produces CYP26A1 which is increased in emphysema, possibly leading to reduced RA availability. These data highlight a role for RA in maintenance of the human pulmonary microvascular endothelium.
Fifteen-Year Follow up of Allogeneic Stem Cell Transplantation in Patients with Myelodysplastic Syndromes Using Busulfan-Based Regimens.
Authors: Ehab Atallah, Joseph Uberti, Lois Ayash, Gail Bentley, Jennifer VanDahm, Voravit Ratanatharathorn
Journal: Blood (2005)
Myeloablative or Reduced Intensity Conditioning Allogeneic Hematopoietic Cell Transplantation for Mantle Cell Lymphoma? a Systematic Review and Meta-Analysis
Authors: Mohamed A. Kharfan-Dabaja, Tea Reljic, Jessica El-Asmar, Taiga Nishihori, Ernesto Ayala, Mehdi Hamadani, Ambuj Kumar
Journal: Blood (2015)
Xenogeneic Bio‐Root Prompts the Constructive Process Characterized by Macrophage Phenotype Polarization in Rodents and Nonhuman Primates
Authors: Hui Li, Jingjing Sun, Jie Li, Hefeng Yang, Xiangyou Luo, Jinlong Chen, Li Xie, Fangjun Huo, Tian Zhu, Weihua Guo, Weidong Tian
Journal: Advanced Healthcare Materials (2017)

Tissue or organ regeneration using xenogeneic matrices is a promising approach to address the shortage of donor matrices for allotransplantation. Success of such approach has been demonstrated to correlate with macrophage-mediated fibrotic homeostasis and tissue remodeling. The previous studies have demonstrated that treated dentin matrix (TDM) could be a suitable bioactive substrate for allogeneic tooth root regeneration. This study constructed xenogeneic bioengineered tooth root (bio-root) via a combination of porcine TDM (pTDM) with allogeneic dental follicle cells (DFCs). Macrophage phenotypes are used to evaluate the remodeling process of xenogeneic bio-roots in vitro and in vivo. pTDM can facilitate odontoblast differentiation of human derived DFCs. Xenogeneic bio-roots in rat subcutaneous tissue prompt constructive response via M1 macrophage infiltration during early postimplantation stages and increase restorative M2 phenotype at later stages. After implantation of bio-roots into jaws of rhesus monkeys for six months, periodontal ligament-like fibers accompanied by macrophage polarization are observed, which are positive for COL-1, Periostin, βIII-tubulin and display such structures as fibroblasts and blood vessels. The reconstructed bio-root possesses biomechanical properties for the dissipation of masticatory forces. These results support that xenogeneic bio-root could maintain fibrotic homeostasis during remodeling process and highlight the potential application of xenogeneic matrices in regenerative medicine.
Early Assessment of Molecular Response in Chronic Myeloid Leukemia Patients On Dasatinib After Imatinib Failure Identify Patients with Poor Cytogenetic and Molecular Responses
Authors: Katia B. Pagnano, Beatriz F Ribeiro, Eliana C M Miranda, Marcia T Delamain, Carmino Antonio De Souza, Gislaine O Duarte, Bruna Vergilio, Dulcinéia Martins Albuquerque, Andrey dos Santos, Anderson Tavares, Irene Lorand-Metze
Journal: Blood (2012)
Bortezomib-Induced Down-Regulation of KIT Is Mediated by Inhibition of Sp1 and NF-kB in AML1/ETO-Positive Cells.
Authors: Shujun Liu, Jiuxia Pang, Jianhua Yu, Zhongfa Liu, Lenguyen Huynh, Jessica Kearney, Peter Paschka, Rebecca B. Klisovic, Robert Baiocchi, William Blum, Danilo Perrotti, Guido Marcucci
Journal: Blood (2006)
Study on the Efficacy of a JAK Inhibitor Pharmacological Agent As Inducer of Fetal Hemoglobin Production in Cultured Erythroid Precursors from Sickle Cell and Beta-Thalassemia Patients
Authors: Alice Pecoraro, Antonio Troia, Angela Vitrano, Rosario Di Maggio, Massimiliano Sacco, Aurelio Maggio, Rosalba Di Marzo
Journal: Blood (2015)