tbuckley/cabot-search huggingface dataset:
Inhaled diesel exhaust alters the allergen-induced bronchial secretome in humans
Authors: Neeloffer Mookherjee, Hadeesha Piyadasa, Min Hyung Ryu, Christopher Francis Rider, Peyman Ezzati, Victor Spicer, Christopher Carlsten
Journal: European Respiratory Journal (2018)

Diesel exhaust (DE) is a paradigm for traffic-related air pollution. Human adaptation to DE is poorly understood and currently based on oversimplified models. DE promotes allergic responses, but protein expression changes mediated by this interaction have not been systematically investigated. The aim of this study was to define the effect of inhaled DE on allergen-induced proteins in the lung. We performed a randomised and blinded controlled human crossover exposure study. Participants inhaled filtered air or DE; thereafter, contralateral lung segments were challenged with allergen or saline. Using label-free quantitative proteomics, we comprehensively defined DE-mediated alteration of allergen-driven secreted proteins (secretome) in bronchoalveolar lavage. We further examined expression of proteins selected from the secretome data in independent validation experiments using Western blots, ELISA and immunohistochemistry. We identified protein changes unique to co-exposure (DE+allergen), undetected with mono-exposures (DE or allergen alone). Validation studies confirmed that specific proteins ( e.g. the antimicrobial peptide cystatin-SA) were significantly enhanced with DE+allergen compared to either mono-exposure. This study demonstrates that common environmental co-exposures can uniquely alter protein responses in the lungs, illuminating biology that mono-exposures cannot. This study highlights the value of complex human in vivo models in detailing airway responses to inhaled pollution.
Defects of the Tpo-Receptor, Mpl, Caused by Mutations Found in CAMT Patients.
Authors: Marloes R. Tijssen, Franca di Summa, Sonja Van den Oudenrijn, Carlijn Voermans, C.Ellen Van der Schoot, Jaap Jan Zwaginga, Masja De Haas
Journal: Blood (2005)
A musical about malignancy
Authors: Richard Hurley
Journal: BMJ (2016)

This performance certainly got Richard Hurley talking about cancer and death



Mark Douet

What starts as a song and dance spectacular about receiving a cancer diagnosis takes an abrupt turn after the interval. Thoroughly demolishing the theatre’s “fourth wall,” the cast of A Pacifist’s Guide to Cancer reassemble without their glittery outfits. One of many real patients who inspired the characters takes to the stage to describe her experience. Then the actors remember their relatives who had cancer. Then they invite the audience to share memories of loved ones who’ve died. We call out names in the dark. There are tears.

Another collaborator, Lara Veitch, has had cancer six times in her 27 years. “Being diagnosed with any serious illness is one of the most shocking things in the world.” she told The BMJ . “Your life spins out of control. That’s why it had to be a musical: it’s big and loud and colourful and mad. The aim is to demystify illness and death.”

She contributed to one of the show’s development workshops topless to show off her scars of double mastectomy. “Not having reconstruction at the age of 24 was difficult for my breast …
Phase II Trial Daily Pulse Interleukin-2 Therapy with Famotidine during Marrow and Lymphocyte Recovery in Acute Myeloid Leukemia: LJCC 0605
Authors: Reed Friend, Ridas Juskevicius, Lauren Salmon, Hemant S. Murthy, James Xenakis, Adam S. Asch, Paul Walker
Journal: Blood (2015)
The Best of Both? Megadose Stem Cells with CD34 Selection and T-Cell Addback Enables Engraftment from Mismatched Unrelated Donors Using Reduced Toxicity Conditioning in Primary Immunodeficiency
Authors: Juliana Montibeller Silva, Kanchan Rao, Robert Chiesa, Stuart Adams, Margaret Brocklesby, Gulrukh Ahsan, Giovanna Lucchini, Paul Veys, Persis Jal Amrolia, Nicholas Goulden
Journal: Blood (2015)
Single-Institute Surveillance of Blood-Stream Infections by Stenotrophomas Maltophilia Among Patients with Hematological Diseases
Authors: Yasuhiko Miyata, Yuki Kojima, Hiroyuki Nakamura, Hideyuki Yamamoto, Hiroatsu Iida, Haruhiko Ohashi, Yasue Hayakawa, Tomoko Okano, Hirokazu Nagai
Journal: Blood (2012)
AB0768 Prevalence of Low Bone Mass in Patient with Early Inflammatory Arthritis Presenting To Early Arthritis Clinic
Authors: A.M. Al Marzooqi, J. Al Saleh
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Low Bone Mineral Density (BMD) was described in patients with inflammatory arthritis. The data on its occurrence at preliminary phase of arthritis onset is insufficient. This study looks into the prevalence of low BMD in patients with early inflammatory arthritis (EIA). <h3>Methods</h3> We reviewed the medical records and electronic files of all patients with synovitis who attended rheumatology clinic between 1st December 2012 and 1st June 2015. Cases with features of synovitis less than two years were only included in the study. The following data was captured; demographics, time of symptom9s onset, results of Dual-energy X-ray absorptiometry (DEXA) scan, and 25-hydroxyvitamin D level (ng/ml). Data are presented as the median values and interquartile range (IQR). The prevalence was described as a fraction. Mann-Whitney test was used to compare those with low BMD and those with normal BMD. <h3>Results</h3> We identified 83 patients with inflammatory arthritis for less than two years only 31 (37.3%) patients underwent DEXA scan. 26 (83.8%) were Emirati9s, 27 (87.0%) were females, and median age was 61 (IQR 57 -65 years). 9 (29%) patients had normal BMD (T-score &gt;-1.0 S.D), 13 (41.9%) patients had osteopenia (T-score between -1.0 and -2.5 S.D), and 9 (29%) patients had osteoporosis (T-score&lt;- 2.5 S.D). Among osteoporotic patients, 4 (12.9%) had osteoporosis at the lumbar spine only, 1 (3.2%) had osteoporosis at neck of the femur, and 4 (12.9%) patients had osteoporosis at both the lumbar spine and neck of the femur. Age was a significant predictor of low BMD in patients with EIA (Z-Score is 2.357, p-value less than 0.02). However, ethnicity, gender, time lag before the initiation of therapy, and vitamin D level did not predict the occurrence of low BMD. <h3>Conclusions</h3> Low BMD is a frequent manifestation in patients with EIA, especially in the elder age group. Prospective studies are required to evaluate the long term significance of low BMD in EIA. <h3>Disclosure of Interest</h3> None declared
Hospitalization Rate and Regional Differences in Comprehensive Care in Transfused Patients with Sickle Cell Disease Compared to Thalassemia: A Report from the Multi-Center Study of Iron Overload.
Authors: Ellen B. Fung, Paul Harmatz, Meredith Milet, Samir K. Ballas, Laura DeCastro, Ward Hagar, Lee Hilliard, William Owen, Kim Smith-Whitley, Elliott Vichinsky
Journal: Blood (2005)
The Determination of Benzoic Acid in Foodstuffs.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0256 Complement C3 Exacerbates TLR7-Mediated Skin Inflammation but Not Systemic Autoimmunity
Authors: C. Giacomassi, G.S. Ling, N. Buang, J. Strid, M. Botto
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Short–term topical application of a Toll-like receptor 7 (TLR7) agonist, Imiquimod (IMQ), is a widely used murine model of psoriasis. Recently long–term epicutaneous application (4–8 weeks) of IMQ has been shown to elicit lupus-like manifestations. Importantly the topical application of IMQ induced more potent systemic effects than the intraperitoneal administration, indicating that activation of the TLR7-signalling in the skin plays a key role. <h3>Objectives</h3> Since complement activation is known to have a crucial role in the regulation of local inflammation and in the pathogenesis of lupus, we investigated whether C3 played a role in the induction of the cutaneous lesions as well as in the lupus-like syndrome triggered by IMQ <h3>Methods</h3> BALB/c wild-type (WT) and C3-deficient (BALB/c.C3<sup>–/–</sup>) mice were treated with topical application of 5% IMQ cream for either 7 consecutive days (short-term) or 3 days /week for 11 weeks (long-term). <h3>Results</h3> After 7 days, skin thickening (ear thickness at day 7: WT 60.14 mm ± 1.625, n=7, vs BALB/c.C3<sup>–/–</sup> 50.88 mm ± 2.460, n=8, p value=0.0094) and local neutrophil recruitment (cell number at day 7: 52.3±6.736, n=7, vs BALB/c.C3<sup>–/–</sup> 30.33±4.192, n=7, p value=0.0170) were significantly reduced in the absence of C3. The expansion of IL17<sup>+</sup> γδ<sup>+</sup> T cells in the draining lymph nodes was also significantly impaired (day 7: WT 59.06% ± 2.961, n=7, vs BALB/c.C3<sup>–/–</sup> 46.21% ± 2.023, n=8, p value=0.0029<i>)</i>. Long-term IMQ treatment resulted in the development of similar low titres of auto-antibodies in both groups of mice (anti-RNP: WT 29.75±11.33, n=5 <i>vs</i> BALB/c.C3<sup>–/–</sup> 97.28±41.53, n=5, p=0.1553; anti-ssDNA: WT 9.252±3.367, n=5, <i>vs</i> BALB/c.C3<sup>–/–</sup>20.70±12.03, n=5, p=0.386; anti-chromatin: WT 12.59±7.001, n=5, <i>vs</i> BALB/c.C3<sup>–/–</sup> 16.72±12.60, n=5, p=0.781). In addition, the kidney histology scored by a trained histopathologist evidenced no difference in the glomerulonephritis severity. <h3>Conclusions</h3> Collectively, these data suggest that C3 acts as a potential mediator of IMQ-induced skin inflammation. However, the different local tissue response does not result in an altered autoimmune response in the C3-deficient mice. The study of the involvement of other complement components is currently in progress. <h3>Disclosure of Interest</h3> None declared
Esophageal leakage after surgical repair of spontaneous rupture: successful closure with endoscopic suture device
Authors: Hon Yip, Philip Chiu, Shannon Chan, Vivien Wong, Anthony Teoh, Simon Wong, Enders Ng
Journal: Endoscopy (2016)

We report a case of successful closure of postoperative esophageal leakage using an endoscopic suture device. A 60-year-old man was initially admitted for spontaneous rupture of the esophagus requiring emergency surgery. Intraoperatively a 3-cm perforation was identified on the right side of the lower esophagus. The mucosal defect was first closed with a laparoscopic linear stapler (Endo GIA Ultra; Covidien, Medtronic, Minneapolis, Minnesota, USA) while the muscular defect was approximated with absorbable interrupted sutures ([Fig. 1]).
Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
Authors: Xiaohong Wang, Jonathan E. Schoenhals, Ailin Li, David R. Valdecanas, Huiping Ye, Fenglin Zang, Chad Tang, Ming Tang, Chang-Gong Liu, Xiuping Liu, Sunil Krishnan, James P. Allison, Padmanee Sharma, Patrick Hwu, Ritsuko Komaki, Willem W. Overwijk, Daniel R. Gomez, Joe Y. Chang, Stephen M. Hahn, Maria Angelica Cortez, James W. Welsh
Journal: Cancer Research (2016)

Abstract Immune checkpoint therapies exhibit impressive efficacy in some patients with melanoma or lung cancer, but the lack of response in most cases presses the question of how general efficacy can be improved. In addressing this question, we generated a preclinical tumor model to study anti-PD-1 resistance by in vivo passaging of Kras-mutated, p53-deficient murine lung cancer cells (p53R172HΔg/+K-rasLA1/+) in a syngeneic host exposed to repetitive dosing with anti-mouse PD-1 antibodies. PD-L1 (CD274) expression did not differ between the resistant and parental tumor cells. However, the expression of important molecules in the antigen presentation pathway, including MHC class I and II, as well as β2-microglobulin, were significantly downregulated in the anti-PD-1–resistant tumors compared with parental tumors. Resistant tumors also contained fewer CD8+ (CD8α) and CD4+ tumor-infiltrating lymphocytes and reduced production of IFNγ. Localized radiotherapy induced IFNβ production, thereby elevating MHC class I expression on both parental and resistant tumor cells and restoring the responsiveness of resistant tumors to anti-PD-1 therapy. Conversely, blockade of type I IFN signaling abolished the effect of radiosensitization in this setting. Collectively, these results identify a mechanism of PD-1 resistance and demonstrate that adjuvant radiotherapy can overcome resistance. These findings have immediate clinical implications for extending the efficacy of anti-PD-1 immune checkpoint therapy in patients. Cancer Res; 77(4); 839–50. ©2016 AACR.
Blockage of TRAF6 by Dominant Negative Peptides to Inhibit Multiple Myeloma (MM) Cell Proliferation and Osteoclast Formation through NF-κB, JNK and AKT Signal Transduction Pathways
Authors: Mingjie Li, Eric Sanchez, Cathy Wang, Megan Schultz, Jessica Wang, Emily Wong, Zhi-Wei Li, Haiming Chen, Benjamin Bonavida, Eddie E Chou, James R. Berenson
Journal: Blood (2010)
Correlation between Angiogenic and Coagulation-Fibrinolysis Factors and Stage of Disease in Non Hodgkin’s Lymphoma Patients.
Authors: Grzegorz Mazur, Malgorzata Poreba, Tomasz Wrobel, Rafal Poreba, Angelika Pyszel, Boguslaw Beck, Aleksandra Steinmetz-Beck, Ryszard Andrzejak, Kazimierz Kuliczkowski
Journal: Blood (2005)
The Spiegelmer Nox-A12, a Novel SDF-1 (CXCL12) Inhibitor, and Its Effects on Chronic Lymphocytic Leukemia (CLL) Cell Migration,
Authors: Julia Hoellenriegel, Dirk Zboralski, Zeev Estrov, William G. Wierda, Michael Keating, Anna Kruschinski, Jan A. Burger
Journal: Blood (2011)
P1211 : Efficacy and safety of sebelipase alfa in children and adults with lysosomal acid lipase deficiency: Results of a phase 3 trial
Authors: S. Rojas-Caro, I. Baric, C. Camarena Grande, M. Coker, P. Deegan, M. DiRocco, F.S. Ezgu, F. Feillet, V. Malinova, E. Mengel, E. Murphy, J. Pastor Rosado, Y. Rahman, M. Scarpa, K.O. Schwab, V. Smolka, J. Taybert, V. Valayannopoulos, Y. Yang, A. Quinn
Journal: Journal of Hepatology (2015)
AB0715 Correlation of Clinical Symptoms and Instrumental Findings in as Coxitis:
Authors: S. Erdes, T. Dubinina, O. Rumyantseva, A. Starkova, M. Podryadnova, S. Krasnenko, A. Demina, M. Urumova, E. Agafonova
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Involvement of the hip joint (coxitis) is one of distinctive manifestations of ankylosing spondylitis (AS), resulting total hip arthroplasty in 5%&gt;7% of cases. <h3>Objectives</h3> To correlate the clinical features of coxitis in AS pts with radiographic and ultrasonographic findings. <h3>Methods</h3> A total of 63 patients (mean age 31,7±12,7 years) with a diagnosis of AS (at the modified New York criteria 1984), having of pain in the hip joints, sequentially admitted for treatment at the clinic. Mean age of disease onset was 30,8±9,6 y. Hip pain was scored using VAS 100 mm. Coxitis was established on the basis of clinical symptoms - the presence of pain and/or limitation of motion in the hip joints at the time of admission of the patient to the clinic. Pelvic radiographs were taken in all pts to determine the severity of hip involvement using BASRI hip scale, and ultrasound examination was made using Sono Diagnost 360 (Philips) with linear (7,5 MHz) and convex (5,0 MHz) transducers. Joint effusion was set when the distance between the signals from the joint capsule and the inner part of the femoral neck was more than 7 mm. <h3>Results</h3> Synovitis on ultrasonography found in 53 (81%) pts out of 61. Pts were grouped into 2 arms based on radiologic findings, i.e. Group with radiographic signs of coxitis and Group without radiographic abnormalities. Two groups comparison data are presented in the Table <h3>Conclusions</h3> Ultrasound allows hip joint to clarify the cause of pain with similar clinical and radiographic manifestations, localized in this area, as well as to determine if the patient has synovitis in the early stages of the coxitis. Patients with radiological coxitis have a longer duration of the disease, severe functional disorders of the index BASFI, with the defeat of the peripheral joints is less common. <h3>Disclosure of Interest</h3> None declared
Right Ventricular Imaging and Computer Simulation for Electromechanical Substrate Characterization in Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Thomas P. Mast, Arco J. Teske, John Walmsley, Jeroen F. van der Heijden, René van Es, Frits W. Prinzen, Tammo Delhaas, Toon A. van Veen, Peter Loh, Pieter A. Doevendans, Maarten J. Cramer, Joost Lumens
Journal: Journal of the American College of Cardiology (2016)
PWE-067 The Effect of Body Position on Baseline Oesophageal Impedance
Authors: A Bray, A Davidson
Journal: Gut (2016)

<h3>Introduction</h3> Our initial experience with 24 hour pH-impedance (pHZ) recording revealed a higher than expected proportion of patients with extended periods of low nocturnal baseline impedance (BImp). Suspecting that this was not always caused by uncleared refluxate, we wished to investigate causes of low BImp. Our aim was to examine the effect of body position on BImp in patients with and without mucosal injury. <h3>Methods</h3> We conducted a retrospective review of 24 hour pHZ data from all patients who have undergone testing within our facility from October 2013 to December 2015. BImp was calculated by averaging 12 × 30 second windows (one window per 2 hour segment) avoiding swallows, reflux events, meals and beverages.<sup>1</sup> Extent of mucosal injury was determined from gastroscopy. <h3>Results</h3> Data from 115 patients (75 without mucosal injury and 40 with grade A to C oesophagitis or Barrett’s oesophagus) were analysed. Overall BImp was dependent upon both extent of mucosal injury (decreasing with increasing mucosal injury) and distance above the lower oesophageal sphincter (LOS) (decreasing distally). In patients <i>without </i>mucosal injury, BImp was only channel-dependent in the upright position. In patients <i>with </i>mucosal injury, BImp was channel-dependent, and more so, in both positions. These results are illustrated in Figure 1. <h3>Conclusion</h3> The difference between upright and supine BImp in patients without mucosal injury at proximal channels may be caused by poorer contact between impedance sensors and mucosa when upright and is therefore unlikely to be clinically significant. The strong dependence of BImp upon channel in patients with oesophagitis suggests that mucosal injury worsens towards the LOS, as expected. One explanation for the difference between upright and supine BImp in these patients at 7 and 9 cm may be more uncleared refluxate at these channels whilst supine. <h3>Reference</h3> 1 Kessing BF, Bredenoord AJ, Weijenborg PW, <i>et al</i>. Esophageal acid exposure decreases intraluminal baseline impedance levels. <i>Am J Gastroenterol</i> 2011;<b>106</b>:2093–7. <h3>Disclosure of Interest</h3> None Declared
A Novel and Pivotal Role of the Mannose-Binding Lectin (MBL) Pathway of Complement Cascade (ComC) Activation in Triggering Mobilization of Hematopoietic Stem/Progenitor Cells (HSPCs)
Authors: Mateusz Adamiak, Ahmed Abdel-Latif, Janina Ratajczak, Mariusz Z Ratajczak
Journal: Blood (2015)
FRI0109 Influence of Aromatase Inhibitors Therapy on The Occurrence of Rheumatoid Arthritis in Women with Breast Cancer. Results from A Large Population Based Study of The Italian Society for Rheumatology:
Authors: M. Caprioli, G. Carrara, S. Pennetta, C.A. Scirè
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Though aromatase inhibitors (AIs) and tamoxifen are an essential part of estrogen receptor-positive breast cancer therapy, many patients discontinue the treatment for musculoskeletal symptoms [1]. Whether the musculoskeletal symptoms can be attributed to an underlying rheumatologic disease remain unknown. Sporadic case reports have described the onset of rheumatoid arthritis (RA) in patients who started therapy with tamoxifen or AIs [2]. <h3>Objectives</h3> The purpose of this study was to evaluate the risk of developing rheumatoid arthritis (RA) in the population of patients with breast cancer treated with AIs. <h3>Methods</h3> Data were collected from the administrative health-care database of Lombardy Region, Italy, from 2004 to 2013. This study follows a nested case-cohort design, including women with diagnosis of breast cancer (ICD9-CM codes 174) starting treatment tamoxifen, anastrozole, exemestane or letrozole. Level of neoplasia was defined according to relevant ICD9-CM codes as localized, node-positive, metastatic, unspecified. The risk of RA related to the prescription of the different drugs was estimated by survival models for competing risks and the results are presented as hazard ratios (HRs) and 95% confidence interval (95% CI), adjusted for age and disease duration. Interaction with age and time varying effects were also explored. <h3>Results</h3> Out of a total of 10493 women with breast cancer with a median (IQR) age of 66 (57–74), 7533 (71.8%) started an active treatment with adjuvant endocrine therapy. In this subgroup of patients a total of 113 new cases of RA developed during the 26105.9 person-year of 10186 exposure periods, including time varying exposures in the same patient. Using tamoxifen as reference category, AIs therapy was associated with an increased risk of RA [adjusted HR 1.62 (95%1.03–2.56)], in particular due to anastrozole, even after adjusting for age and level of neoplasia (Table). Interaction with age was not statistically significant, and no time varying effects were observed. <h3>Conclusions</h3> In a large population-based sample of women with breast cancer, the exposure to AI therapy compared with tamoxifen is associated with a significantly increased risk of developing RA, which is not influenced by the cancer severity and the relationship of age with indication to specific drugs. In patients with breast cancer treated with AIs and presenting arthralgia referral to rheumatologist is useful to exclude the onset of rheumatoid arthritis. <h3>References</h3> Din OS, et al. Breast Cancer Res Treat 2010;120:525–38. Bertolini E, et al. Jt Bone Spine Rev Rhum 2011;78:62–4. <h3>Disclosure of Interest</h3> None declared
High-Resolution SNP-Array Profiling Discloses Novel Genomic Aberrations in BCR/ABL-Negative Myeloproliferative Neoplasms with Myelofibrosis
Authors: Frank Stegelmann, Lars Bullinger, Martin Griesshammer, Susanne Kuhn, Stefanie Schauer, Katja Urlbauer, Simone Miller, Karlheinz Holzmann, Hartmut Dohner, Konstanze Dohner
Journal: Blood (2008)
Molecular diagnosis of bloodstream infections in onco-haematology patients with PCR/ESI-MS technology
Authors: Elena Jordana-Lluch, Belén Rivaya, Clara Marcó, Montserrat Giménez, Mª Dolores Quesada, Agustín Escobedo, Montserrat Batlle, Elisa Martró, Vicente Ausina
Journal: Journal of Infection (2016)
Daptomycin non-susceptible Enterococcus faecium in leukemia patients: Role of prior daptomycin exposure
Authors: Adam J. DiPippo, Frank P. Tverdek, Jeffrey J. Tarrand, Jose M. Munita, Truc T. Tran, Cesar A. Arias, Samuel A. Shelburne, Samuel L. Aitken
Journal: Journal of Infection (2016)