tbuckley/cabot-search huggingface dataset:
AB0452 Changes in Lipoproteins Associated with Tocilizumab Treatment Do not Influence the Atherogenic Index of Plasma of Rheumatoid Arthritis Patients: Table 1
Authors: F. Cacciapaglia, A. Maria Grazia, A. Rinaldi, C. Scioscia, G. Lopalco, M. Covelli, F. Iannone, G. Lapadula
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Interleukin-6 inhibition by tocilizumab (TCZ) has been associated with changes in the lipoprotein profile [1], which could adversely impact cardiovascular (CV) risk in patients with rheumatoid arthritis (RA) [2]. <h3>Objectives</h3> The aim of this observational study is to evaluate the effect of TCZ on lipoproteins and on the atherogenic index of plasma (AIP), a useful predictor of cardiovascular risk [3]. <h3>Methods</h3> Forty patients (36 female; age 55±11 yrs) with active RA and an inadequate response to DMARDs treated with 8 mg/kg TCZ every 4 weeks intravenously, were consecutively enrolled with a 1 year follow-up. Patients on hypolipidemic therapy were excluded. Before and on week 12, 24 and 52, DAS28 and CDAI were evaluated, and blood samples were taken to assess plasmatic levels of total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), and to calculate the AIP (LogTG/HDL). <h3>Results</h3> During the first 24 weeks of TCZ treatment we observed a progressive increase of about 10% for TC and TG, and of about 30% for LDL-C and HDL-C compared to baseline. In the subsequent 6 months there was a reduction of TC and TG, whereas HDL-C and LDL-C continued to increase to about 40% compared to baseline (see Table). Lipid changes were inversely correlated with both the disease activity scores DAS28 and CDAI. Contextually the AIP was stable around 1, with no statistically significant changes. During the observational period no CV events have been observed. <h3>Conclusions</h3> TCZ acts on the lipid profile increasing all the lipoprotein fraction, especially during the first 6 months of treatment, probably by a direct hepatic effect [4]. On the contrary the net effect of TCZ on AIP, and consequently on CV risk, would seem to be irrelevant. <h3>References</h3> Kawashiri SY et al. Rheumatol Int. 2011 Souto A et al. Arthr Rheumatol 2015 Gasevic D et al. Lipids Health Dis. 2014 Strang AC et al. Atherosclerosis 2013 <h3>Disclosure of Interest</h3> None declared
Efficacy and safety of lumacaftor/ivacaftor combination therapy in patients with cystic fibrosis homozygous for Phe508del CFTR by pulmonary function subgroup: a pooled analysis
Authors: J Stuart Elborn, Bonnie W Ramsey, Michael P Boyle, Michael W Konstan, Xiaohong Huang, Gautham Marigowda, David Waltz, Claire E Wainwright
Journal: The Lancet Respiratory Medicine (2016)
An Autoradiographic Study of Tumor Dynamics
Authors: James C. Reid, Julius White
Journal: JNCI Journal of the National Cancer Institute (1959)

Autoradiograms of sections of tumors labeled in vivo, by giving a single dose of a labeled amino acid to the host, were examined for the pattern of uptake. Two rat tumors and 2 mouse tumors were investigated with glycine-1-C14 and L-lysine-U-C14. Similar results were obtained with all combinations. No gradients of isotope concentration are observable in viable tissue at any time from 7 hours to 2 weeks after the administration of amino acid. Necrotic tissue does not fix isotope, and labeled tissue on becoming necrotic releases isotope only very slowly. The observations as a whole suggest that tumor proteins are not distinguished by a non-dynamic character, and that peripheral growth is not a factor of particular significance in the propagation of tumors.
Case 4-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, David B. Bernard, Dbri Kiprov
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 48-year-old woman was admitted to the hospital because of renal failure.She was well until 11 days earlier, when she began to have peripheral edema, followed by fever, diarrhea, nausea, a transient sore throat, and considerable malaise. One week before admission she noticed a decrease in urinary volume. Three days before entry she consulted a physician, who found tenderness in the right lower abdominal quadrant, questionable hepatic enlargement, and peripheral edema. Laboratory examination showed azotemia, and she was referred to this hospital.The patient's only medications were aspirin for headaches and terbutaline hydrochloride for long-standing asthma. . . .
Prenatal Antidepressant Use and Risk of Autism Spectrum Disorders in Children—Reply
Authors: Anick Bérard, Takoua Boukhris
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
THU0615-HPR Conceptions After Total Hip Replacement in Patients Who are Not Satisfied with the outcome Of Surgery. a Qualitative Content Analysis
Authors: C. Bocké, G. Garellick, O. Rolfson, C. Thorstensson
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In Sweden, one year after primary total hip replacement, implant survival is close to 100% while the patient satisfaction is barely 90%. Through patient reported outcomes, Swedish Hip Arthroplasty Register have identified persons who scored uncertain or dissatisfied with the outcome of surgery at one year follow up. The aim of this study was to illuminate conceptions on the outcome of total hip replacement in persons who reported uncertainty or dissatisfaction with the outcome of surgery one year postoperatively. <h3>Objectives</h3> Informants were recruited via Swedish Hip Arthroplasty Register9s database of patients with total hip replacement. <h3>Methods</h3> Semistructured interviews were conducted with twenty-two persons, (fifteen women and seven men), aged 49-85 years, about their experiences of the outcome after total hip replacement. The interviews were analyzed with qualitative content analysis. <h3>Results</h3> The informants were desiring for solid and prolonged support and guidance when life was restricted by disability. They described experiences of limitations due to impairments influencing their well-being and activities of daily life and also a lack of support. Four different categories emerged: Life restrictions by disability, Negative impacts on daily living, Sense of insufficient support and treatment, Caregivers9 scarce availability. <h3>Conclusions</h3> Dissatisfaction after the outcome of total hip replacement is a complexed issue involving discomfort in many areas of life. None of the informants reported that their expectations were fully met. Guidance and support from healthcare are important issues for patients, even though the intervention is considered complete and is approved by the orthopaedic clinic. <h3>References</h3> Graneheim UH, Lundman B. Qualitative content analysis in nursing research: concepts, procedures and measures to achieve trustworthiness. Nurse Educ Today. 2004;24(2):105-12. Rolfson O, Kärrholm J, Dahlberg LE, Garellick G. Patient-reported outcomes in the Swedish Hip Arthroplasty Register: results of a nationwide prospective observational study. J Bone Joint Surg Br. 2011;93(7):867-75. <h3>Acknowledgements</h3> The informants who shared their experiences with us. <h3>Disclosure of Interest</h3> None declared
AB0578 Fatigue is Closely Associated with Quality of Life in Patient with PSS and Younger Age, the Presence of Autonomic Dysfunction and Xerostomia is the Major Determinant of Severe Fatigue
Authors: J.H. Koh, J. Lee, S.-M. Jung, H.K. Min, J.H. Kim, H. Jeon, S.-K. Kwok, J.H. Ju, S.-H. Park
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Purpose</h3> To describe outcomes and complications following Descemet9s stripping automated endothelial keratoplasty (DSAEK) in eyes with pseudophakic bullous keratopathy (BK) while retaining the anterior chamber intraocular lenses (ACIOL). <h3>Methods</h3> We included consecutive patients who underwent DSAEK for BK at a single tertiary centre from 1 January 2008 to 1 April 2010, from our prospective cohort (Singapore Corneal Transplant Study). We compared eyes with BK, which underwent DSAEK while retaining ACIOL (n=18), to those with DSAEK alone with the posterior chamber intraocular lenses left in place as a comparison group (n=114). Main outcome measures were endothelial cell (EC) loss and graft survival. <h3>Results</h3> The percentage EC loss at 1 year was 31.9±21.3% in the DSAEK with ACIOL group compared to 24.5±21.2% in the DSAEK group (p=0.516); however, this figure was significantly greater in the DSAEK with ACIOL group at 3 years compared to the DSAEK group (55.3±29.2% vs 33.3±20.8%; p=0.01 respectively). Graft survival was also significantly poorer in the DSAEK ACIOL group compared to the DSAEK group over 3 years (log rank p=0.002). <h3>Conclusions</h3> We found that although eyes with BK and ACIOL that underwent DSAEK while retaining the ACIOL suffered EC loss which was not significantly greater at 1 year, EC loss and graft survival were significantly poorer compared to DSAEK controls at 3 years postoperatively.
AB1053 Diagnostic Utility of Anti-Citrullinated Protein Antibody (Anti-CCP) Compared with Rheumatoid Factor (RF) in Rheumatoid Arthritis (RA) in a Philippine Tertiary Care Setting
Authors: G.M. Garcia, M.J. Estanislao, C. Pedarse, N. Trinidad
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint swelling, tenderness, and destruction of synovial joints, leading to severe disability. Early diagnosis is important because early initiation of disease modifying treatments can significantly improve long term outcomes of patients with RA. Most specialists rely on a combination of clinical acumen and laboratory studies to make a diagnosis. The rheumatoid factor assay (RF) has been used for over 50 years as part of the American College of Rheumatology (ACR) classification criteria despite its shortcomings. Thus, the anti-citrullinated peptide (anti-CCP) was developed as a diagnostic test for RA, with initial studies showing high sensitivity and specificity among RA patients even in the presence of other rheumatic diseases or infectious diseases. To date, there have been no published studies on the sensitivity and specificity of anti-CCP in the Philippines. <h3>Objectives</h3> To determine the sensitivity and specificity of anti-CCP compared with RF assay in the Philippines. <h3>Methods</h3> This is a cross-sectional analytical study, which reviewed medical records of patients with both RF and anti-CCP from Jan 2012 to Dec 2013. Inclusion criteria included presence of clinical synovitis in at least one joint as seen by a rheumatologist. Subjects were then scored using the 2010 ACR/EULAR RA classification criteria, which served as the gold standard. A diagnosis of RA was made with a score of ≥6. Sensitivity and specificity for RF, anti-CCP, and combined RF and anti-CCP were calculated. <h3>Results</h3> Out of 334 records retrieved, 208 subjects were included. The ACR/EULAR RA classification criteria showed 41 cases with RA. The mean age of the group was 47±14 years, majority being female at 83.3%. The sensitivity and specificity of anti-CCP were both higher than RF assay for the diagnosis of RA, which were 87.8% and 100% versus 68.3% and 98.8%, respectively. When both RF and anti-CCP tests were combined, the sensitivity and specificity were 60.98% and 100%, respectively, which showed that anti-CCP alone still fared better as a diagnostic test. <h3>Conclusions</h3> Anti-CCP is useful for the diagnosis of RA due to its higher sensitivity and specificity compared with RF or even in combination with RF assay. Therefore in the Philippine setting, it can be used alone as both a screening and confirmatory serological marker, because under the 2010 ACR/EULAR classification criteria for RA, both tests (RF and anti-CCP) are scored equally. <h3>Disclosure of Interest</h3> None declared
Inspiratory muscle training to enhance recovery from mechanical ventilation: a randomised trial
Authors: Bernie M Bissett, I Anne Leditschke, Teresa Neeman, Robert Boots, Jennifer Paratz
Journal: Thorax (2016)

<h3>Background</h3> In patients who have been mechanically ventilated, inspiratory muscles remain weak and fatigable following ventilatory weaning, which may contribute to dyspnoea and limited functional recovery. Inspiratory muscle training may improve inspiratory muscle strength and endurance following weaning, potentially improving dyspnoea and quality of life in this patient group. <h3>Methods</h3> We conducted a randomised trial with assessor-blinding and intention-to-treat analysis. Following 48 hours of successful weaning, 70 participants (mechanically ventilated ≥7 days) were randomised to receive inspiratory muscle training once daily 5 days/week for 2 weeks in addition to usual care, or usual care (control). Primary endpoints were inspiratory muscle strength and fatigue resistance index (FRI) 2 weeks following enrolment. Secondary endpoints included dyspnoea, physical function and quality of life, post-intensive care length of stay and in-hospital mortality. <h3>Results</h3> 34 participants were randomly allocated to the training group and 36 to control. The training group demonstrated greater improvements in inspiratory strength (training: 17%, control: 6%, mean difference: 11%, p=0.02). There were no statistically significant differences in FRI (0.03 vs 0.02, p=0.81), physical function (0.25 vs 0.25, p=0.97) or dyspnoea (−0.5 vs 0.2, p=0.22). Improvement in quality of life was greater in the training group (14% vs 2%, mean difference 12%, p=0.03). In-hospital mortality was higher in the training group (4 vs 0, 12% vs 0%, p=0.051). <h3>Conclusions</h3> Inspiratory muscle training following successful weaning increases inspiratory muscle strength and quality of life, but we cannot confidently rule out an associated increased risk of in-hospital mortality. <h3>Trial registration number</h3> ACTRN12610001089022, results.
Outpatient Surgery
Authors: Melinda Maggard-Gibbons, Claudia A. Steiner
Journal: JAMA (2014)

Pamela L. Owens, PhD; Marguerite L. Barrett, MS; Susan Raetzman, MSPH; Melinda Maggard-Gibbons, MD, MSHS; Claudia A. Steiner, MD, MPH
Cogwheel rigidity related to lithium maintenance
Authors: B Shopsin, S Gershon
Journal: American Journal of Psychiatry (1975)

Neurological examinations of 27 outpatients receiving lithium carbonate maintenance therapy for recurrent affective illness revealed that most of the patients receiving lithium for more than 8 months had cogwheel rigidity. The data suggest a positive correlation between the duration of lithium maintenance and the severity of cogwheeling. Intravenous administration of benztropine, an antiparkinsonian drug, did not abolish or significantly ameliorate this symptom.
Bilateral Papillary Adenomas of the Epididymides
Authors: S M GRANT, E F HOFFMAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Influence of Inoculum Size on Proliferation in Tissue Cultures
Authors: Wilton R. Earle, Katherine K. Sanford, Virginia J. Evans, Helen K. Waltz, John E. Shannon, Jr.
Journal: JNCI Journal of the National Cancer Institute (1951)

The Influence of Inoculum Size on Proliferation in Tissue Cultures Get access Wilton R. Earle, Wilton R. Earle National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Katherine K. Sanford, Katherine K. Sanford National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia J. Evans, Virginia J. Evans National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Helen K. Waltz, Helen K. Waltz National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar John E. Shannon, Jr. John E. Shannon, Jr. National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 1, August 1951, Pages 133–153, https://doi.org/10.1093/jnci/12.1.133 Published: 01 August 1951 Article history Received: 18 April 1951 Published: 01 August 1951
Prevalence and Predictors of Inappropriate Delivery of Palliative Thoracic Radiotherapy for Metastatic Lung Cancer
Authors: Matthew Koshy, Renuka Malik, Usama Mahmood, Zain Husain, Ralph R. Weichselbaum, David J. Sher
Journal: JNCI Journal of the National Cancer Institute (2015)

Background:High-level evidence has established well-recognized standard treatment regimens for patients undergoing palliative chest radiotherapy (RT) for stage IV non–small cell lung cancer (NSCLC), including treating with fewer than 15 fractions of RT, and not delivering concurrent chemoradiation (CRT) because of its increased toxicity and limited efficacy in the palliative setting.
Cutaneous Recording and Stimulation of Muscles Using Organic Electronic Textiles
Authors: Maria Papaiordanidou, Seiichi Takamatsu, Shahab Rezaei‐Mazinani, Thomas Lonjaret, Alain Martin, Esma Ismailova
Journal: Advanced Healthcare Materials (2016)

Electronic textiles are an emerging field providing novel and non-intrusive solutions for healthcare. Conducting polymer-coated textiles enable a new generation of fully organic surface electrodes for electrophysiological evaluations. Textile electrodes are able to assess high quality muscular monitoring and to perform transcutaneous electrical stimulation. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
AB0779 Should Ultrasound Coxitis Criteria in Ankylosing Spondylitis be Reviewed?: Table 1.
Authors: M. Podryadnova, M.M. Urumova, T.V. Dubinina, R.M. Balabanova, S.F. Erdes
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hip joints are the most commonly affected part of locomotor system in ankylosing spondylitis (AS) patients, imposing serious functional limitations. Hip joints involvement is diagnosed in 56% of AS patients in Russia, being the cause of 7% total hip replacement surgeries. <h3>Objectives</h3> To study ultrasound features of AS coxitis in hospitalized patients. <h3>Methods</h3> The study included 220 consecutive AS patients (criteria 1984), hospitalized to V. A. Nasonova Research Institute of Rheumatology during the period 2012-13 yy. Mean patients9 age was 36,3±10,2. Mean age at disease onset - -30,6±11,0 y. 82% of patients were HLA-B27-positive, disease activity by BASDAI - 4,5±2,1, ASDAS - 3,3±1,2. Functional BASFI index was 4,4±2,6. All patients were subjected to routine clinical examination. Hip joints ultrasound examination was performed with Sono Diagnost 360 (Philips) using linear (7,5 MHz) and convex (5,0 MHz) transducers. Transudation in the joint space was registered when the distance between signals from the capsule and medial aspect of femoral neck was ≥7 mm [1]. <h3>Results</h3> Transudation in the joint space based on established US ≥7 mm distance was found in 119 (54%) patients, 104 (83%) out of them also had clinical signs and symptoms of coxitis (pain and functional limitations). Patients9 clinical data of both subgroups – with and without US coxitis criteria - are presented in the Table. Both subgroups were comparable by demographic parameters. Higher disease activity, CRP levels and BASFI scores (i.e. functional impairment) are evident in patients with US diagnosed transudation. 15 patients with US symptoms of sinoviitis had no clinical manifestations of coxitis. In these patients the capsular-neck distance did not exceed 8 mm. <h3>Conclusions</h3> Clinical manifestations accompany US-diagnosed coxitis only when capsular-neck distance is ≥8 mm. More studies are warranted to establish upper limit of the normal US-measured distance between the capsule and femoral neck for US final diagnosis of coxitis. <h3>References</h3> Koski J.M., Antilla P.J., Isomaki H.A. Ultrasonography of the adult hip joint. Scand. J. Rheumatol., 1989, 18, 113-119. <h3>Disclosure of Interest</h3> None declared
Alcohol, General Anesthetics Influence Level of Anticoagulant Dosage
Authors: W E GRAHAM
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal