tbuckley/cabot-search huggingface dataset:
AB1079 Verification of an Ultrasonographic Scoring System in Discriminating Rheumatoid from Osteoarthritic and Normal Joints in an Egyptian Cohort
Authors: N. Abaza, N. Gadallah, M. Elhosseiny, S.A. El-Bakry, S. Yousry
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Musculoskeletal ultrasound (MSUS) use in Rheumatoid arthritis (RA) has been growing over the last decades mainly to monitor response to treatment and for early detection of erosions. Suggestions to involve this technique in RA diagnosis were taking place but not yet implicated (due to absence of specific sonographic criteria confined to RA). <h3>Objectives</h3> To verify a proposed combined structural and synovial scoring system9s (designed by Kunkel et al., 2012) performance in discriminating RA from osteoarthritis and healthy sonographic findings in small joints of the hand. <h3>Methods</h3> Twenty RA patients, 20 hand OA patients and 10 healthy controls were subjected to MSUS to metacarpophalyngeal (MCP) and proximal interphalyngeal (PIP) joints. The novel proposed scoring system was applied characterizing each joint as either RA-supported (according to presence of synovial thickening&gt;2mm, doppler signal and/or erosion) or RA-unsupported. Grading of synovitis as mild, moderate or severe was also applied. In RA group, disease activity was assessed by DAS28 and Anti-CCP serum levels were measured. <h3>Results</h3> Upon applying this scoring system, high statistically significant difference was found between study groups (Table 1) as regards presence of synovium&gt;2mm, doppler signal (Figure 1) and erosions. When one or more RA-supported joints were detected, this scoring system had a sensitivity of 100.0% and specificity of 83.0% with diagnostic accuracy of 90.0% for diagnosis of RA. If two or more joints were detected, it had a sensitivity of 95.0% and specificity of 96.7.0% with diagnostic accuracy of 96.0% for diagnosis of RA. <h3>Conclusions</h3> The novel suggested combined structural and synovial scoring system showed high performance in differentiating RA from OA and controls. <h3>References</h3> Kunkel GA, Canon GW and Clegg DO: Combined Structural and Synovial Assessment for Improved Ultrasound Discrimination of Rheumatoid, Osteoarthritic, and Normal Joints: A Pilot Study. The Open Rheumatology Journal 2012;6: 199-206. Scheel AK, Hermann KG, Kahler E, Pasewaldt D, Fritz J, Hamm B, Brunner E, Müller GA, Burmester GR, Backhaus M: A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis. Arthritis Rheum 2005; 52: 733-43.12. <h3>Disclosure of Interest</h3> None declared
Spectrum and frequency of use of statistical techniques in psychiatric journals
Authors: J A Hokanson, S G Bryant, R Gardner, D J Luttman, B G Guernsey, A C Bienkowski
Journal: American Journal of Psychiatry (1986)

Educators in psychiatry face an important challenge in deciding what quantitative skills to teach and where in the educational agenda to teach them. One strategy is to focus the quantitative training of psychiatrists on techniques they need to be effective consumers of their literature. The authors catalogued the statistical methods described in 15 major psychiatric journals during 1983 and 1984. A dozen procedures, typically encountered in intermediate-level statistics courses, accounted for approximately 95% of all the statistical methods reported. Readers of psychiatric journals also routinely encounter multivariate, nonparametric, and categorization techniques. Educators might apply these results in designing exposure to statistical skills for future psychiatrists.
Management of Advanced-Phase Chronic Myelogenous Leukemia
Authors: Jerald P Radich
Journal: Journal of the National Comprehensive Cancer Network (2016)

Chronic myelogenous leukemia represents the poster child of successful precision medicine in cancer, with amazing survival results achieved with targeted tyrosine kinase inhibitors (TKIs) in many patients with chronic-phase disease. Unfortunately, however, this good news has not extended to patients in blast crisis, for whom survival has not clearly been improved with TKIs. During his presentation at the NCCN 21st Annual Conference, Jerald P. Radich, MD, briefly explored the biology behind advanced-stage disease and several of the molecular findings in disease progression. He also reviewed some of the therapeutic options in advanced disease, emphasizing that transplantation, although fraught with some difficulties, offers the best long-term prognosis for patients in blast crisis.
Prevention of Rheumatic Fever
Authors: L DE VEL
Journal: BMJ (1956)

Rheumatic fever is in most instances preventable. In 1953 the Committee on the Prevention of Rheumatic Fever of the American Heart Association published a valuable outline report setting forth the recommended preventive measures in detail.<sup>1</sup>Now, after two years, they have brought this report up-to-date.<sup>2</sup>In addition to minor changes in wording, the new report stresses the fact that in treating streptococcic infections effective blood levels of penicillin must be maintained for 10 days regardless of the patient's clinical improvement in order to prevent rheumatic fever by eradicating streptococci from the throat. In addition to dosages for procaine penicillin with aluminum monostearate in oil they give those for benzathine penicillin G, which because of its prolonged action is preferred. In order to prevent streptococcic infections in rheumatic persons continuous prophylactic treatment should be given to all those who have a well-established history of a previous attack of rheumatic
Ambulatory Surgery
Authors: Don E. Detmer
Journal: New England Journal of Medicine (1981)

Before the development of general anesthesia and the modern hospital, most patients recuperated from surgery at home. Care on the hospital ward was the fate of the indigent or the soldier. In time surgeons and patients realized that both care and results were better in hospitals. Consequently, there were strong pressures to perform all major operations in hospitals. Indeed, the vast improvement in the quality of surgical care that took place in the United States during this century was dependent on the performance of most major surgical procedures in hospitals where peer review, quality control, accreditation, and educational activities developed. . . .
HIV-related risk behaviors among psychiatrically hospitalized adolescents and school-based adolescents
Authors: R J DiClemente, L E Ponton
Journal: American Journal of Psychiatry (1993)

The authors compared the responses of 76 adolescents on an inpatient psychiatric service with those of 802 school-based adolescents in the same city regarding HIV risk behaviors. The psychiatrically hospitalized adolescents reported a significantly higher rate of sexual and drug-related behaviors that involve a risk for contracting sexually transmitted disease, including HIV-related illnesses.
Rabid puppy-dog imported into the Netherlands from Morocco via Spain, February 2012
Authors: G G van Rijckevorsel, C M Swaan, J P van den Bergh, A Goorhuis, D Baayen, L Isken, A Timen, A van den Hoek
Journal: Eurosurveillance (2012)

In February 2012 a rabid puppy dog was imported into Amsterdam, the Netherlands from Morocco via Spain. In a joint action between the Netherlands’ Food and Consumer Product Safety Authority, the Public Health Service of Amsterdam and the Centre for Infectious Disease Control all exposed human and animal contacts were traced and, when necessary, provided with post-exposure prophylaxis. During the importation, the international legislations with respect to vaccination requirements were not fully obeyed by veterinarians and custom services.
Autoantibodies directed against CD43 molecules with an altered glycosylation status on human immunodeficiency virus type 1 (HIV-1)- infected CEM cells are found in all HIV-1+ individuals
Authors: V Giordanengo, M Limouse, L Desroys du Roure, J Cottalorda, A Doglio, A Passeron, JG Fuzibet, JC Lefebvre
Journal: Blood (1995)
Continuous renal replacement therapy versus intermittent hemodialysis in intensive care patients: impact on mortality and renal recovery
Authors: Anne-Sophie Truche, Michael Darmon, Sébastien Bailly, Christophe Clec’h, Claire Dupuis, Benoit Misset, Elie Azoulay, Carole Schwebel, Lila Bouadma, Hatem Kallel, Christophe Adrie, Anne-Sylvie Dumenil, Laurent Argaud, Guillaume Marcotte, Samir Jamali, Philippe Zaoui, Virginie Laurent, Dany Goldgran-Toledano, Romain Sonneville, Bertrand Souweine, Jean-Francois Timsit
Journal: Intensive Care Medicine (2016)
A Novel Chemotherapeutic Agent to Treat Tumors with DNA Mismatch Repair Deficiencies
Authors: Yongliang Zhang, Jennifer T. Fox, Young-Un Park, Gene Elliott, Ganesha Rai, Mengli Cai, Srilatha Sakamuru, Ruili Huang, Menghang Xia, Kyeryoung Lee, Min Ho Jeon, Bijoy P. Mathew, Hee Dong Park, Winfried Edelmann, Chan Young Park, Sung You Hong, David Maloney, Kyungjae Myung
Journal: Cancer Research (2016)

Abstract Impairing the division of cancer cells with genotoxic small molecules has been a primary goal to develop chemotherapeutic agents. However, DNA mismatch repair (MMR)-deficient cancer cells are resistant to most conventional chemotherapeutic agents. Here we have identified baicalein as a small molecule that selectively kills MutSα-deficient cancer cells. Baicalein binds preferentially to mismatched DNA and induces a DNA damage response in a MMR-dependent manner. In MutSα-proficient cells, baicalein binds to MutSα to dissociate CHK2 from MutSα leading to S-phase arrest and cell survival. In contrast, continued replication in the presence of baicalein in MutSα-deficient cells results in a high number of DNA double-strand breaks and ultimately leads to apoptosis. Consistently, baicalein specifically shrinks MutSα-deficient xenograft tumors and inhibits the growth of AOM-DSS–induced colon tumors in colon-specific MSH2 knockout mice. Collectively, baicalein offers the potential of an improved treatment option for patients with tumors with a DNA MMR deficiency. Cancer Res; 76(14); 4183–91. ©2016 AACR.
Epidemic St. Louis Encephalitis in Houston, 1964
Authors: R T BARTON
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Meta-analysis of subjective sensitivity to alcohol in sons of alcoholics
Authors: V E Pollock
Journal: American Journal of Psychiatry (1992)

Meta-analysis was used to review the research literature on self-reported sensitivity to alcohol among sons of alcoholic and among normal control subjects.Computerized and manual searches identified 17 eligible independent articles; nine contained the information necessary to compute effect sizes, and additional data on two other studies were provided by authors in response to written and telephone requests.Findings from 10 studies indicated that sons of alcoholics report significantly less sensitivity to alcohol than normal control subjects overall and during the ascending (i.e., 0-35 minutes after alcohol) and descending (i.e., 40-240 minutes after alcohol) limbs of the blood alcohol curve. Response to placebo did not significantly distinguish these groups in the five studies that included such assessment.It may be appropriate to appraise the biological sons of male alcoholics that they may experience less subjective sensitivity to alcohol than other individuals, but it is not possible to predict whether any particular individual will experience such lower sensitivity. In addition, self-report data can be influenced by many factors, and further research that assesses multiple psychological and physiological measures and uses longitudinal designs is needed to determine the relationship between specific factors and the development of alcoholism.
Research on Iodine Metabolism in Endemic Goiter in Piedmont
Authors: A COSTA, F COTTINO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Public health in the European overseas countries and territories: New perspectives for Europe
Authors: C M Gossner, T Van Cangh, D Coulombier
Journal: Eurosurveillance (2011)

Preview this article: Public health in the European overseas countries and territories: New perspectives for Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/29/art19920-en-1.gif
Endoscopic reinforcement of the anastomosis followed by targeted endoscopic hemostasis for massive upper gastrointestinal bleeding after Whipple’s surgery
Authors: Marco D’Assunçao, Paul Kröner, Ujjwal Kumar, Juan Gutierrez, Lucia Fry, Klaus Mönkemüller
Journal: Endoscopy (2016)

Although it occurs infrequently in patients undergoing the procedure, upper gastrointestinal (GI) bleeding after Whipple's gastropancreaticoduodenectomy can be a devastating complication. Early GI bleeding that occurs within 24 to 48 hours postoperatively is an important cause of morbidity and mortality [1]. Emergency endoscopic procedures performed within a short time after major surgery have traditionally been discouraged on the grounds that insufflation may disrupt the anastomotic site and lead to perforation. Therefore, some experts use interventional radiology with embolization [2]. Herein, we present a novel endoscopic approach and solution to the management of a patient with renal failure and a contraindication to interventional radiology after Whipple's surgery.
Symposium
Authors: L N KATZ, G E BURCH, A DORFMAN, C ERNSTENE, H H HECHT, R L PARKER
Journal: Circulation (1958)

A panel discussion on unsettled clinical questions in the management of cardiovascular disease was conducted at the Thirtieth Scientific Sessions of the American Heart Association held at the Sherman Hotel, Chicago, Friday afternoon, October 25, 1957. The panel was comprised of the following members: LOUIS N. KATZ, Chicago, Ill. , MODERATOR; GEORGE E. BURCH, New Orleans, La. ; ALBERT DORFMAN, Chicago, Ill. ; A. CARLTON ERNSTENE, Cleveland, Ohio; HANS H. HECHT, Salt Lake City, Utah; and ROBERT L. PARKER, Rochester, Minn.
Long-Term Survival in Multiple Myeloma
Authors: S F Bierman
Journal: New England Journal of Medicine (1983)

Key Clinical MessageThe survival of multiple myeloma patients has improved very significantly over the last decade.Still median overall survival is inferior to 5 years.A small proportion of patients survive longer than 10 years.In this paper we discuss four cases illustrating the nonhomogeneous clinical presentation and evolution of this subset of patients.Surprisingly, these long survivors do not always have deep responses and some require frequent treatments, which include autologous stem cell transplantation and novel drugs.The authors discuss several aspects of these clinical histories, including treatment options, raising hypothesis on their relation with long survivorship which may be important to have in consideration when studying this subject.
PTU-060 The clinical and financial impact of a virtual clinic for biological therapies in inflammatory bowel disease
Authors: A Boal, S Squires, B Reed, R Hamid, M Heydtmann, G Naismith
Journal: Gut (2015)

<h3>Introduction</h3> Anti-Tumour Necrosis Factor (Anti-TNF) therapy is recognised as an effective treatment for use in Inflammatory Bowel Disease (IBD). Current NICE guidance<sup>1</sup>recommends that disease status should be reassessed every twelve months. This Study aims to assess the impact of a formal IBD team case review by prospectively monitoring clinical and financial outcomes over 12 months. <h3>Method</h3> Between April and July 2013, a virtual biological clinic was set up over three dates. Forty-five patients who were receiving Anti-TNF therapy for treatment of IBD at the Royal Alexandra and Vale of Leven hospitals, underwent review. The investigatory group consisted of three consultant gastroenterologists, two IBD clinical nurse specialists and one gastroenterology registrar. Case notes and clinical data via the hospital information system were examined to determine whether investigations were up to date and to identify patients who would benefit from treatment alterations. Data was recorded for significant clinical outcomes for 12 months from the date of implementation of any change to treatment regimen proposed at the virtual clinic. <h3>Results</h3> Forty-five patients who were receiving treatment with Anti-TNF therapy (Infliximab n = 34, Adalimumab n = 11) were reviewed. Over the course of twelve months following introduction of the virtual clinic, 14 patients receiving Infliximab therapy and 5 receiving Adalimumab were withdrawn from treatment as they were deemed to have achieved clinical remission. 2 patients had their dosage of Adalimumab reduced from weekly to fortnightly dosing. 1 patient had their treatment and management transferred to their local hospital. 6 patients were switched from Infliximab to Adalimumab as they were thought to be failing therapy. Of the 19 patients withdrawn from therapy, 2 patients had clinical relapse of symptoms during 12 months. These patients were recommenced on treatment, achieving full remission. No patients required steroid therapy or hospital admission due to de-escalation of therapy. The reduction in biological expenditure over 12 months was £236936.34. Cost savings highlight the price of medication only and do not reflect staff time or clinic costs. <h3>Conclusion</h3> A virtual biologics clinic ensures that patients on Anti-TNF treatments have disease reassessment and are on appropriate treatment as per clinical guidelines. The interventions appear to have been both safe and cost-effective in this cohort. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> NICE Guidelines – CE technology appraisals [TA187] Published date: May 2010 Infliximab (review) and Adalimumab for the treatment of Crohn’s disease
Note on Some Aspects of the Effect of Nucleates in Primary and Transplanted Rat Hepatomas
Authors: Jesse P. Greenstein, Harold W. Chalkley
Journal: JNCI Journal of the National Cancer Institute (1946)

Note on Some Aspects of the Effect of Nucleates in Primary and Transplanted Rat Hepatomas Jesse P. Greenstein, Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold W. Chalkley Harold W. Chalkley senior physiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 6, Issue 4, February 1946, Pages 207–209, https://doi.org/10.1093/jnci/6.4.207 Published: 01 February 1946
Hepatitis and Blood Transfusion.
Authors: L SCHALM
Journal: Annals of Internal Medicine (1973)

to prevent the development of resistance Dr Redeker and Dr Chalmers, report for the treatment of serious Pseudomonas extensive experience in applying Aus- and some Proteus infections.Anyone tralia antigen testing in clinical situations.reading this book might use it in small The problems associated with the intro- doses to treat chronic bronchitis!I am duction of hyperimmune globulin are sure that is not what Professor May aired by Drs Prince and Krugman and
Continuity of care in the delivery of mental health services
Authors: R Tessler, J H Mason
Journal: American Journal of Psychiatry (1979)

The authors report on the help-seeking experiences of people referred to community settings for aftercare on discharge from a state mental hospital in western Massachusetts. They present results that bear on three questions relevant to public policy issues in the mental health field: 1) the proportion of patients who comply with referrals to aftercare agencies, 2) the social and psychological characteristics of patients who comply with these referrals, and 3) the impact of receiving aftercare on the probability of rehospitalization.