tbuckley/cabot-search huggingface dataset:
P4-09-15: Clinical and Pathological Predictors of Outcome among Patients with Triple Negative Breast Cancer.
Authors: DB Pearlstone, M Gray, RM Garofalo, M Trapani, T Nyirenda, VA Hazelwood
Journal: Cancer Research (2011)

Abstract Background Triple negative (TN) breast cancer portends a poor prognosis, yet outcomes remain heterogeneous. Specific characteristics of individual TN patients that can predict outcome compared to non-triple negative (NTN) patients have yet to be well defined. Methods: A prospective oncology database at Hackensack University Medical Center was queried for all patients with invasive breast cancer between 2000 and 2005. Patients with triple negative breast cancer were identified and compared to non-triple negative patients. Numerical values were compared by Mann-Whitney test; categorical values by Chi square/Fisher exact test. Log-rank test was used to compare outcome statistics, univariate and multivariate analyses were used to identify factors affecting relapse-free survival and overall survival. Results: A total of 2,216 patients were identified (TN: n=260; NTN: n=1956). There was no difference in race (white vs non-white; TN: 82.3% vs NTN: 87.3%) or family history of breast cancer (TN: 19.2% vs NTN: 16.8%). TN patients were significantly younger (median age; TN: 55.5 vs NTN 57.7; p&amp;lt; .05), had larger tumors (mean cm; TN: 3.1 vs NTN: 2.4; p&amp;lt;.05), had higher grade tumors (% grade 3; TN:74.6 vs NTN: 26.1; p&amp;lt;.0001), had higher proliferation index (&amp;gt;20% nuclei stained for Ki-67; TN: 30.8% vs NTN: 6.7%; p&amp;lt;.0001), but were less likely to have lymph node metastases at presentation (TN: 35.7% vs NTN: 48.0%; p &amp;lt; .0001). Among node negative patients, overall survival (OS) and disease free survival (DFS) were not significantly different between TN and NTN. Among node positive patients, both OS and DFS were worse for TN patients compared to NTN patients (p &amp;lt; .0008). By univariate analysis, age, nodal status, tumor size and tumor grade were all independent predictors of DFS, but proliferation rate and TN status were not. In a multivariate analysis, however, age, TN status, nodal status and tumor size were all significantly associated with DFS. Conclusion: Although TN patients have poor outcomes overall, among node negative patients, TN status does not affect overall nor disease free survival. Among node positive patients, however, TN status has a significant impact on outcome. In this analysis, well established predictors of outcome, including age, tumor size, tumor stage and nodal status were all independent predictors of outcome, but TN status and Ki-67 level were not. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-09-15.
A7.06 Low-dose IL-2 therapy in refractory sle: Insights from a phase I/IIA clinical trial
Authors: JY Humrich, C von Spee-Mayer, E Siegert, M Bertolo, D Abdirama, A Rose, P Enghard, A Radbruch, GR Burmester, G Riemekasten
Journal: Annals of the Rheumatic Diseases (2016)

<h3></h3> Interleukin-2 (IL-2) is crucial for the growth and survival of regulatory T cells (Treg), and thus for the control of autoimmunity. In previous studies we have proven the significance of an acquired IL-2 deficiency and related Treg defects in the pathogenesis of systemic lupus erythematosus (SLE). Accordingly, we showed that compensation of IL-2 deficiency by IL-2 therapy corrects associated Treg defects and ameliorates already established disease in lupus-prone mice.<sup>1</sup> Proceeding to a clinical translation of IL-2 therapy for SLE, we recently reported a rapid and robust reduction of disease activity in parallel to a remarkable expansion of the Treg population by low-dose IL-2 therapy in one patient with refractory SLE.<sup>2</sup> In addition, we showed that Treg defects in SLE patients are associated with IL-2 deficiency, and can be selectively corrected <i>in vitro</i> and <i>in vivo</i> with low doses of IL-2.<sup>3</sup> Together, these studies provided the rationales for the clinical implementation an IL-2-based immunotherapy for the treatment of SLE with the aim to restore Treg activity and thus to re-establish endogenous mechanisms of immune tolerance. Here, we present results from the ongoing phase I/IIa clinical trial (PRO-IMMUN) addressing the safety, tolerability, immunological responses and clinical efficacy of a subcutaneous low-dose IL-2 therapy in patients with refractory SLE. <h3>References</h3> Humrich JY, <i>et al</i>. Homeostatic imbalance of regulatory and effector T cells due to IL-2 deprivation amplifies murine lupus. Proc Natl Acad Sci USA. 2007;107(1):204–209 Humrich JY, <i>et&nbsp;al</i>. Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE. Ann Rheum Dis. 2015. doi: 10.1136/annrheumdis-2014-206506 von Spee-Mayer&nbsp;C,&nbsp;<i>et al</i>. Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. <i>Ann Rheum Dis. </i>Aug 31 2015. doi: 10.1136/annrheumdis-2015-207776. [Epub ahead of print]
Syncope after Eating
Authors: Wolfgang Schima, Fritz Sterz, Peter Pokieser
Journal: New England Journal of Medicine (1993)

To the Editor: A 62-year-old physician from Moscow was admitted to the emergency department of the University Hospital in Vienna because of fainting after eating at a medical-convention banquet. In the ambulance on the way to the hospital, atrial fibrillation with a rapid rate was noted, and a physician administered 5 mg of verapamil intravenously. The physical examination and electrocardiogram in the emergency room showed a hemodynamically stable patient with sinus tachycardia. The chest film showed almost complete opacification of the right hemithorax, with normal findings in the left lung (Figure 1). The mottled appearance of the opacification was atypical . . .
TIME IN THERAPEUTIC RANGE (TTR): ANALYSIS IN A LARGE OBSERVATIONAL COHORT TAKING WARFARIN FOR CHADS2 MEASURED RISK IN NON-VALVULAR ATRIAL FIBRILLATION PATIENTS
Authors: Orna Reges, Morton Leibowitz, Moshe Hoshen, Yoav Arnson, Ran Balicer, Moti Haim
Journal: Journal of the American College of Cardiology (2016)
Radiation-induced nondisjunction.
Authors: I A Uchida
Journal: Environmental Health Perspectives (1979)

The methodology and results of epidemiological studies of the effects of preconception diagnostic x-rays of the abdomen on chromosome segregation in humans are described. Many studies have been conducted in a number of different countries. The vast majority show the same positive, though not significant, trend to increased nondisjunction among the offspring of irradiated women. The results of the various studies, however, cannot be pooled because of differing methodologies used. A worldwide co-operative project with standardized methodology is recommended. Such a study should identify the parental origin of the nondisjunctional event before etiological factors are investigated. Abnormal chromosome segregation during mitotic division has been inducted experimentally by the in vitro exposure of human lymphocytes to a low dose of 50 R gamma irradiation. First meiotic nondisjunction has been successfully induced by whole body exposure of female mice to a low dose of radiation. Further experiments are being conducted to try to induce abnormal segregation during second meiotic division. Because of difficulties encountered in trying to estimate total gonad doses resulting from differing techniques employed by radiologists and other health personnel, no attempt has been made to estimate the doubling dose nor minimum safe dose regarding the effects of radiation on chromosome segregation in humans. The question of time-related repair of the mechanism involved in chromosome segregation is raised.
Technology Lends Itself to Breast Imaging
Authors: P. Eastman
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Technology Lends Itself to Breast Imaging Get access Peggy Eastman Peggy Eastman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 22, 16 November 1994, Pages 1669–1671, https://doi.org/10.1093/jnci/86.22.1669 Published: 16 November 1994
Systemic Treatment of Primary Tuberculosis
Authors: Robert Debré
Journal: New England Journal of Medicine (1956)

TODAY, various drugs are available that have proved very active against tubercle bacilli. It is known that the sooner they are resorted to, the more effective they will be. It is therefore more than ever necessary to diagnose any form of tuberculosis as early as possible since a delay in the recognition of severe tuberculous manifestations can entail heavy consequences. But, in my opinion, this applies also to primary tuberculosis, even of the most benign type, which should be diagnosed as soon as feasible.The important problem at present is whether all cases of primary tuberculosis — whether latent or . . .
Pulmonary-Function Abnormalities after Lymphangiography
Authors: W. M. Gold, J. Youker, S. Anderson, J. A. Nadel
Journal: New England Journal of Medicine (1965)

IODIZED oil (Ethiodol) infused directly into the lymphatic vessels permits radiographic visualization of remote lymph nodes in the pelvis and retroperitoneum and has proved to be valuable in the management of cancer involving the reticuloendothelial system.1 , 2 In a review of over 4000 patients examined by means of lymphangiography respiratory symptoms and clinical evidence of pulmonary vascular obstructions were rare.1 Although only 1 of our patients complained of "chest tightness" after the procedure the results of specialized pulmonary-function tests indicated transient obstruction of pulmonary capillaries in every case. Anatomic studies in dogs confirmed that oil microemboli lodged in pulmonary capillaries.Methods . . .
Elemental Mercury Embolism to the Lung
Authors: F Gutiérrez, L Leon
Journal: New England Journal of Medicine (2000)

Figure 1. A 21-year-old dental assistant attempted suicide by injecting 10 ml (135 g) of elemental mercury (quicksilver) intravenously. She presented to the emergency room with tachypnea, a dry cough, and bloody sputum. While breathing room air, she had a partial pressure of oxygen of 86 mm Hg. A chest radiograph showed that the mercury was distributed in the lungs in a vascular pattern that was more pronounced at the bases. The patient was discharged after one week, with improvement in her pulmonary symptoms. Oral chelation therapy with dimercaprol was given for nine months, until the patient stopped the treatment; . . .
Long-Term Follow-up of Hodgkin's Disease Trial
Authors: George P. Canellos, Donna Niedzwiecki
Journal: New England Journal of Medicine (2002)

To the Editor: In 1992, we reported the results of the prospective, randomized Cancer and Leukemia Group B trial in patients with newly diagnosed, advanced-stage Hodgkin's disease. The study compared three regimens: MOPP (mechlorethamine, vincristine, procarbazine, and prednisone) for 6 to 8 months, the standard treatment at that time; ABVD, a nonalkylating-agent–containing regimen (doxorubicin, bleomycin, vinblastine, and dacarbazine) for 6 to 8 months; and MOPP alternating with ABVD for 12 months.1 Radiation therapy was not administered. ABVD therapy alone for 6 to 8 months resulted in a rate of failure-free survival similar to the rate with a 12-month regimen of . . .
How High Can the Standardized Uptake Value Be?
Authors: MARC HICKESON, HONGMING ZHUANG, THOMAS K. CHACKO, ABASS ALAVI
Journal: Clinical Nuclear Medicine (2002)

HICKESON, MARC M.D.; ZHUANG, HONGMING M.D., Ph.D.; CHACKO, THOMAS K. M.D.; ALAVI, ABASS M.D. Author Information
Treatment of mild to moderate hypertension. Diuretic or beta-blockers?
Authors: Gakuji Nomura, Shiro Arai, Masatomo Maekawa, Hiromichi Ohta, Toshikazu Takabatake
Journal: Circulation (1981)

The effectiveness of diuretic and β-blockers was analyzed in relation to pretreatment plasma renin activity (PRA), plasma volume (PV) and patient's age in mild to moderate essential hypertension. Following results were obtained. 1) Diuretic was more effective in patients with low and normal PRA, high and normal PV, and elderly age, compared to patients with high PRA, low PV, and juvenile age, respectively. 2) Effect of β-blockers (pindolol and oxprenolol) was not different among PRA and PV subclasses. It was more effective in juvenile patients, especially younger than 35 years old compared with elderly patients. 3) In patients with low and normal PRA or with high and normal PV, and in elderly patients, diuretic was more effective than β-blockers. 4) In juvenile patients β-blockers were more effective than diuretic.
Abstract LB-62: Breast Cancer Research Advocacy
Authors: Lorry Blath, Lorry Blath
Journal: Cancer Research (2011)

Abstract Lorry Blath works with fellow research advocates who are breast cancer survivors with a passion for learning the science of breast cancer and applying it to a variety of local and national opportunities. Advocates support research by understanding and conveying the patient's point of view to the medical and research community. The St. Louis Research Advocacy Committee is the only such group associated with a Susan G. Komen Affiliate in the country. At the advocacy monthly meetings members review articles, mentor each other, introduce activities that match their advocacy interests and talents, and invite speakers several times a year to the “Ask the Expert” series. In the last two years the speakers have included: Dr. Graham Colditz, Dr. Ron Bose, Dr. Shiela Stewart, Dr. Will Gillanders, Dr. Craig Allred, and representatives from the Breast Navigation Program. The committee organizes a workshop to introduce advocacy to potential candidates. This seminar presents volunteer and educational opportunities, basic breast cancer science, and encourages the attendees to set personal goals. Two breast cancer researchers give lectures in their particular area of interest, followed by demonstrations in their labs. After the workshop, the attendees choose their level of involvement: they may serve in official capacities as community representatives on hospital IRBs, DoD grant reviewers, Komen national and community grant reviewers, and asked to collaborate with scientists on their grant submissions. A few aspire to more advanced instruction by representing Susan G. Komen at national research and/or educational conferences and sharing their gained knowledge with the group. In April, 2011, the research advocacy committee will hold its first RA201 workshop. This seminar, to be held at the Washington University Genome Center, will host breast cancer scientists explaining their original research. The committee's first community-wide event will take place in March at the Missouri History Museum. Based on The Immortal Life of Henrietta Lacks, this book discussion will reach constituencies from a variety of St. Louis neighborhoods. A panel, consisting of a History professor of African American Studies, a clinical trial analyst, and a physician/medical ethicist, will lead the discussion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-62. doi:10.1158/1538-7445.AM2011-LB-62
Bone and In-111 Octreotide Imaging in Oncogenic Osteomalacia
Authors: CARLOS A. GARCIA, RICHARD P. SPENCER
Journal: Clinical Nuclear Medicine (2002)

Osteoporosis associated with aging is considered the most common cause of bone mineral loss. Osteomalacia, abnormal bone loss with excess osteoid formation, is another cause. A 46-year-old man was examined for chronic hip and lower extremity pain that had not been relieved by nonsteroidal anti-inflammatory drugs or steroids. A bone scan revealed multiple foci of activity. The serum calcium level was normal, but phosphorus values were low. These results did not correspond with the indications for typical hyperparathyroid disease, so another cause was sought. An In-111 octreotide scan showed a focus in the right humeral head. At surgery, a phosphaturic tumor of mesenchymal origin was partially resected. Oncogenic osteomalacia is related to secretion of a phosphaturic material from a fibroblast growth factor.
Effect of Age at Loss of Dietary Control on Intellectual Performance and Behavior of Children with Phenylketonuria
Authors: Neil A. Holtzman, Richard A. Kronmal, William van Doorninck, Colleen Azen, Richard Koch
Journal: New England Journal of Medicine (1986)

We determined the effect on intellectual performance and behavior of the age at which dietary control was lost in 119 10-year-old children with phenylketonuria (PKU) who had started on a diet low in phenylalanine before the age of 65 days. The children's diets were considered to be out of control when their blood phenylalanine concentration persistently exceeded 15 mg per deciliter. The age at which control was lost was the best, and frequently the only, predictor of the child's IQ at the age of 8 or 10 years and of the deficit in the child's IQ as compared with those of his or her unaffected siblings or parents. The age at which control was lost was also the best predictor of the deficit in scores on the Wide Range Achievement Test of children with PKU at the age of eight, as compared with their unaffected siblings, and of behavior problems (Louisville Behavior Checklist). Variables that were not significant included the maximal phenylalanine concentration before dietary therapy, the age at which treatment was started, and the family's coping abilities. The greatest deficiencies in all of these outcomes were observed among children who were out of dietary control before the age of six years. The highest correlation between the IQs of the children with PKU and their respective parents was observed among the children still on the diet at the age of eight years; the lowest, among those who had poor dietary control before the age of six. These findings suggest that phenylalanine restriction should continue after the age of eight years in children with PKU.
P739 RISK FACTORS AND TREATMENT OUTCOMES IN GENOTYPE 1 AND GENOTYPE 4 HEPATITIS C INFECTED PATIENTS FROM A REAL WORLD DATA ANALYSIS IN EUROPE
Authors: C. Moreno, Y. Horsmans, R. Flisiak, H. Van Vlierberghe, E. Trepo, P. Starkel, J. Jaroszewicz, A. Geerts, M. Pisini, L. Lantican, D. Koletzki
Journal: Journal of Hepatology (2014)
Western Medicine: An Illustrated History, by Ed Irvine Loudon
Authors: A. Dally
Journal: BMJ (1998)

Ed Irvine Loudon Oxford University Press, £25, pp 346 ISBN 0 19 820509 0

The history of medicine, new style, is becoming increasingly popular. Run by historians more than by doctors, it banishes antiquarianism, “great discoveries,” “great men,” and professional self satisfaction. It welcomes all aspects of medicine in historical context. As a result, there has been a recent plethora of large, beautifully illustrated books written by experts with the aim of giving a bird's eye view. This is one such book and …
Cyclooxygenase-2 (COX-2) Expression in a Cohort of Greek Patients with Colorectal Cancer (CRC)
Authors: Tzilves Dimitrios, Patakiouta Frinda, Pilpilidis Ioannis, Lazaraki Georgia, Xiroy Persefoni, Tarpagos Anestis
Journal: Annals of Oncology (2014)
AB0893 Joint manifestations of inflammatory bowel disease
Authors: K. Berrada, L. Tahiri, F. Lazrak, M. El Yousfi, M. El Abkari, A. Ibrahimi, N. Abda, C. Nejjari, T. Harzy
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Extraintestinal manifestations occur rather frequently in inflammatory bowel disease (IBD). Rheumatic manifestations are the most common and are associated with a wide range of clinical patterns. <h3>Objectives</h3> To estimate the prevalence of joint manifestations in chronic inflammatory bowel disease and to identify risk factors of their occurrence. <h3>Methods</h3> Cross-sectional study of 114 cases of IBD collected in gastroenterology and rheumatology departments of a Moroccan teaching hospital on a period of 9 months (from April 2009 to December 2010). Data were analyzed using SPSS. A multivariate logistic regression was used. <h3>Results</h3> Seventy-three women and fourty-one men were included in the study. Their mean age was 38.5±14 year. IBD onset was at an average age of 35±14 years. Fifty-two patients were diagnosed with ulcerative colitis (UC) and 62 with Crohn’s disease. Joint manifestations were present in 71.1% of cases. The prevalence of axial involvement, peripheral involvement, and enthesis involvement were 72.8%, 90.1% and 40.7% respectively. Radiological changes were identified in 52.63% of cases; 7.9% of patients had isolated asymptomatic sacroiliitis. 52.6% of cases satisfied the criteria of The European Spondyloarthropathy Study Group (ESSG), 28.1% of them satisfied the modified New York criteria. In univariate analysis, factors associated with joint damage were female gender, CRP&gt;10 mg/l, high ESR and extensive UC. In multivariate analysis, only female sex (OR =3.02 [95% CI: 1,14-8]), CRP&gt;10 mg/l (OR =5.51 [95% CI: 1,39-21, 82]) and high ESR (OR =9.18 [95% CI: 1,80-46, 83]) were selected as predictors of joint damage in IBD. <h3>Conclusions</h3> Musculoskeletal involvements are the most important extra digestive manifestations of IBD. Compared with the North African series, our results highlight the predominance of peripheral versus axial arthritis. Their screening should be systematic for patients with IBD especially if they are female and if they have a biological inflammatory syndrome, allowing early diagnosis and better treatment. <h3>Disclosure of Interest</h3> None Declared
DO PATIENTS WHO MEET CLASS IIA INDICATIONS FOR CARDIAC RESYNCHRONIZATION THERAPY ATTAIN A THERAPEUTIC BENEFIT?
Authors: Gregory Sinner, Vedant Gupta, Arash J. Seratnahaei, Kevin Parrott, Richard Charnigo, Yousef Darrat, Samy Elayi, Steve Leung, Vincent Sorrell
Journal: Journal of the American College of Cardiology (2016)
Case 39-2010
Authors: Lawrence S. Friedman, Michael S. Gee, Joseph Misdraji
Journal: New England Journal of Medicine (2010)

A 19-year-old woman was transferred to this hospital because of nausea, jaundice, and pruritus. She was 3 months post partum. Examination revealed no spider angiomas, palmar erythema, telangiectasias, abdominal tenderness, or organomegaly. Bilirubin and aminotransferase levels were elevated.
A Startling Decline
Authors: Mikael L. Rinne, Scott M. McGinnis, Martin A. Samuels, Joel T. Katz, Joseph Loscalzo
Journal: New England Journal of Medicine (2012)

An 89-year-old man was brought to the ER by his wife and son for an evaluation of changes in cognition and personality. Six months earlier, he began needing help managing finances and operating his computer. He had poor memory for recent events and difficulty expressing himself.
356 ROLE OF GPR30-ADENYLYL CYCLASE (AC)-PKA PATHWAY IN ESTRADIOL 17β-GLUCURONIDE (E17G) INDUCED CHOLESTASIS IN ISOLATED RAT HEPATOCYTES COUPLETS (IRHC) AND ISOLATED PERFUSED RAT LIVER (IPRL)
Authors: A. Zucchetti, I.R. Barosso, A.C. Boaglio, E.J. Ochoa, C. Davio, M.G. Roma, F.A. Crocenzi, E.J. Sanchez Pozzi
Journal: Journal of Hepatology (2012)