tbuckley/cabot-search huggingface dataset:
The madness of art
Authors: L Edel
Journal: American Journal of Psychiatry (1975)

The author finds a constant thread of what Benjamin Rush termed "tristimania" in works of great authors. The madness of art, Henry James's description of the need to transform and metamorphose personal experience by means of prose, poetry, or other artistic expression, is illustrated in the lives and works of many great writers. Psychotherapy as a means of dealing with depression in artists can be either rejected or used to advantage. The author posits that the most enduring works may be those of artists who have lived through their sadness to experience and control their rage against aging.
Controllable and uncontrollable stress in humans: alterations in mood and neuroendocrine and psychophysiological function
Authors: A Breier, M Albus, D Pickar, T P Zahn, O M Wolkowitz, S M Paul
Journal: American Journal of Psychiatry (1987)

The authors exposed 10 healthy human volunteers to the stress of loud (100 dB) noise under controllable and uncontrollable conditions on two separate days. Subjects reported higher self-ratings of helplessness, lack of control, tension, stress, unhappiness, anxiety, and depression; had greater hypothalamic-pituitary-adrenal axis function as measured by elevations in plasma adrenocorticotropic hormone; and had higher levels of sympathetic nervous system and electrodermal activity after the uncontrollable stress condition than after exposure to controllable stress. Thus, lack of control over even a mildly aversive stimulus can produce alterations in mood as well as neuroendocrine and autonomic nervous system changes in healthy subjects.
Preventing Venous Thromboembolism After Surgery
Authors: Lindsey Kreutzer, Christine Minami, Anthony Yang
Journal: JAMA (2016)

Venous thromboembolism (VTE) is the number one cause of potentially preventable death in hospitalized patients.

Venous thromboembolism is a serious and preventable condition in patients who have undergone recent surgery. There are 2 forms of VTE: deep vein thrombosis (DVT) and pulmonary embolism (PE). Deep vein thromboses occur when a blood clot forms in the deep veins, most commonly in the arms or legs. Pulmonary embolisms occur when a DVT breaks off and becomes lodged in the lungs. Venous thromboembolism accounts for 100 000 patient deaths per year.
Stressful life events and symptom onset in HIV infection
Authors: R C Kessler, C Foster, J Joseph, D Ostrow, C Wortman, J Phair, J Chmiel
Journal: American Journal of Psychiatry (1991)

The authors' goal is to provide basic epidemiologic data on the issue of reactivity to stress and HIV symptom onset by studying the relationship between a broad set of naturally occurring stressor events and HIV natural history in a large longitudinal community sample of HIV-seropositive homosexual men.Subjects were recruited from a cohort of 1,011 homosexual men enrolled in the Chicago site of the Multicenter AIDS Cohort Study who also participated in the Coping and Change Study. The men were given self-administered questionnaires assessing behavioral, psychological, and psychosocial variables. Relationships between reports of stressful life events and longitudinal biomedical data measuring illness progression were examined. Life events were assessed by reports on the numbers of lovers, friends, and acquaintances who were diagnosed with AIDS or had died of AIDS and by scores on a checklist of 24 more general serious stressor events. The variables indicating progression of illness among initially asymptomatic men were a drop in T-helper lymphocyte percent (CD4%) between pairs of examinations of at least 25% and onset between examinations of thrush and/or fever lasting a minimum of 2 weeks.The authors found no evidence that serious stressor events have any meaningful effect on symptom onset indicated by either a drop in CD4% or onset of fever or thrush.There is no need for asymptomatic people with HIV infection to restrict their lives in order to avoid exposure to stressful life experiences or to develop special skills for coping with stress to forestall the progression of HIV illness.
Changes in conceptions in women younger than 18 years and the circumstances of young mothers in England in 2000–12: an observational study
Authors: Kaye Wellings, Melissa J Palmer, Rebecca S Geary, Lorna J Gibson, Andrew Copas, Jessica Datta, Anna Glasier, Rachel H Scott, Catherine H Mercer, Bob Erens, Wendy Macdowall, Rebecca S French, Kyle Jones, Anne M Johnson, Clare Tanton, Paul Wilkinson
Journal: The Lancet (2016)

BackgroundIn 2000, a 10-year Teenage Pregnancy Strategy was launched in England to reduce conceptions in women younger than 18 years and social exclusion in young parents. We used routinely collected data and data from Britain's National Surveys of Sexual Attitudes and Lifestyles (Natsal) to examine progress towards these goals.MethodsIn this observational study, we used random-effects meta-regression to analyse the change in conception rates from 1994–98 to 2009–13 by top-tier local authorities in England, in relation to Teenage Pregnancy Strategy-related expenditure per head, socioeconomic deprivation, and region. Data from similar probability sample surveys: Natsal-1 (1990–91), Natsal-2 (1999–2001), and Natsal-3 (2010–12) were used to assess the prevalence of risk factors and their association with conception in women younger than 18 years in women aged 18–24 years; and the prevalence of participation in education, work, and training in young mothers.FindingsConception rates in women younger than 18 years declined steadily from their peak in 1996–98 and more rapidly from 2007 onwards. More deprived areas and those receiving greater Teenage Pregnancy Strategy-related investment had higher rates of conception in 1994–98 and had greater declines to 2009–13. Regression analyses assessing the association between Teenage Pregnancy Strategy funding and decline in conception rates in women younger than 18 years showed an estimated reduction in the conception rate of 11·4 conceptions (95% CI 9·6–13·2; p<0·0001) per 1000 women aged 15–17 years for every £100 Teenage Pregnancy Strategy spend per head and a reduction of 8·2 conceptions (5·8–10·5; p<0·0001) after adjustment for socioeconomic deprivation and region. The association between conception in women younger than 18 years and lower socioeconomic status weakened slightly between Natsal-2 and Natsal-3. The prevalence of participation in education, work, or training among young women with a child conceived before age 18 years was low, but the odds of them doing so doubled between Natsal-2 and Natsal-3 (odds ratio 1·99, 95% CI 0·99–4·00).InterpretationA sustained, multifaceted policy intervention involving health and education agencies, alongside other social and educational changes, has probably contributed to a substantial and accelerating decline in conceptions in women younger than 18 years in England since the late 1990s.FundingMedical Research Council, Wellcome Trust, Economic and Social Research Council, and Department of Health.
THE PHYSICIANS OF THE FRENCH REVOLUTION.
Authors: G Birtalan
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P5-15-05: The expression of genes involved in cholesterol biosynthesis is heterogeneous in breast cancer and may predict sensitivity to statin treatment and clinical outcome
Authors: S Kimbung, M Feldt, A Bosch, S Borgquist
Journal: Cancer Research (2016)

Abstract Background: Epidemiological evidence supports a protective role of cholesterol lowering drugs against breast cancer recurrence. Preclinical studies also support this role since statins can suppress breast cancer progression in various models. The response of breast cancer cells to statin treatment is however heterogeneous. We performed a comprehensive molecular characterisation of the anti-cancer mechanisms of statins in-vitro in view of identifying biomarkers of statin sensitivity in breast cancer. Methods: Breast cancer cell lines were treated with atorvastatin and the effects on cell proliferation were determined. A panel of cell lines displaying a diverse range of sensitivity to atorvastatin treatment were selected for gene expression microarray profiling following treatment. Differentially expressed genes were identified and subjected to gene ontology analysis and links to outcome following breast cancer diagnosis were explored. Results: Statin treatment elicited a more potent inhibition of proliferation in estrogen receptor (ER) negative cell lines. This was reflected on the whole genome transcriptional scale as the ER negative cells also displayed a more robust dysregulation of mRNA transcripts relative to the less-sensitive ER expressing cells. Down-regulation of DNA replication, regulation of cell cycle progression, and other proliferation-associated biological processes via mechanisms influencing the transcriptional activity of E2F was observed in the statin-sensitive cells. Importantly, cholesterol biosynthesis via the mevalonate pathway was upregulated in all cell lines following statin treatment. This effect was directly correlated with the pre-treatment expression levels of target genes involved in this biological process, suggesting a link with sensitivity to statin treatment. The expression of cholesterol biosynthesis genes was also found to be variable in primary breast tumors and a significant association was observed between decreased expression and an improved recurrence-free and overall survival, especially in ER positive tumors. Conclusions: These data suggest that the normal feedback regulation of the mevalonate pathway induced by statins may be compromised in a subset of breast cancer cells and may be exploited to predict breast cancer prognosis and sensitivity to statin treatment. Citation Format: Kimbung S, Feldt M, Bosch A, Borgquist S. The expression of genes involved in cholesterol biosynthesis is heterogeneous in breast cancer and may predict sensitivity to statin treatment and clinical outcome. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-15-05.
Benzodiazepine use and abuse by patients at outpatient clinics
Authors: A Rifkin, S Doddi, B Karajgi, N Hasan, L Alvarez
Journal: American Journal of Psychiatry (1989)

The charts of 2,719 patients from several outpatient clinics were reviewed for evidence of use and abuse of benzodiazepines. According to the chart data and interviews with physicians, no patient met the criteria for benzodiazepine abuse or dependence.
Usefulness of Statistical Models To Assess the Benefit of Breast Cancer Screening
Authors: Bernard S. Pasternack, Philip Strax
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Usefulness of Statistical Models To Assess the Benefit of Breast Cancer Screening Get access Bernard S. Pasternack, Bernard S. Pasternack Department of Environmental Medicine New York University School of MedicineNew York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar Philip Strax Philip Strax Stella and Charles Guttman Breast Diagnostic InstituteNew York, New York 10016 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 63, Issue 5, November 1979, Pages 1109–1110, https://doi.org/10.1093/jnci/63.5.1109 Published: 01 November 1979
MENTAL HYGIENE IN CHILDHOOD
Authors: A F DA FONSECA
Journal: JAMA (1929)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Altered Tyrosine Phosphorylation Via the Very Late Antigen (VLA)/β1 Integrin Stimulation Is Associated With Impaired T-Cell Signaling Through VLA-4 After Allogeneic Bone Marrow Transplantation
Authors: Toshiya Sato, Yoshiyuki Ohashi, Kouichi Tachibana, Robert J. Soiffer, Jerome Ritz, Chikao Morimoto
Journal: Blood (1997)
Porta hepatis schwannoma diagnosed by endoscopic ultrasound-guided fine-needle biopsy
Authors: César Lopes, Uirá Teixeira, Fábio Waechter, José Sampaio, Antônio Hartmann
Journal: Endoscopy (2015)

A 30-year-old white woman was referred 5 months ago for evaluation of an isolated episode of moderate abdominal pain in the upper-right quadrant. An abdominal computed tomography scan revealed a heterogeneous low-attenuation tumor, measuring 4 cm in size in the porta hepatis, which was compressing the portal vein and touching the common bile duct ([Fig. 1]).
Development and Implementation of Expected Practices to Reduce Inappropriate Variations in Clinical Practice
Authors: S. Monica Soni, Paul Giboney, Hal F. Yee
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children
Authors: Agnieszka Szmigielska, Grazyna Krzemien, Maria Roszkowska-Blaim
Journal: New England Journal of Medicine (2010)

In the second sentence of the third paragraph (page 77), "generate and secrete large amounts" should have read "generate large amounts."In Figure 1 (page 78), "Asparagine synthetase secreted" should have read "Asparagine secreted," and the first sentence of the figure legend should mention "asparagine" rather than "asparagine synthetase."The article has been corrected at NEJM.org.Antibiotic Prophylaxis and Recurrent Urinary Tract Infection in Children (October 29, 2009;361:1748-59).In Table 2 (page 1756), under "Renal scan at 1 yr," the words "at baseline" should not have followed "Normal results" and "Abnormal results."Under "Normal results" and "Abnormal results," the words "as compared with baseline" should follow "Unchanged" (two instances), "Resolved," "Improved," and "Worse."We regret the error.The article has been corrected at NEJM.org.
PRODIGE: A phase III randomized placebo-controlled trial of thromboprophylaxis using dalteparin low molecular weight heparin (LMWH) in patients with newly diagnosed malignant glioma
Authors: J. R. Perry, L. Rogers, N. Laperriere, J. Julian, W. Geerts, G. Agnelli, M. Malkin, R. Sawaya, R. Baker, M. Levine
Journal: Journal of Clinical Oncology (2007)

2011 Background: Venous thromboembolism (VTE) occurs in 20–30% of patients with malignant glioma per year of survival. We have conducted an RCT testing the efficacy and safety of long-term dalteparin for the prevention of VTE in newly diagnosed malignant glioma. Methods: Adults with newly diagnosed malignant glioma were randomized to receive dalteparin 5,000 anti-Xa units or placebo, both subcutaneously daily for 6 months starting within the first month after surgery. Patients were allowed to continue study medication for up to 12 months. Because of the poor prognosis of malignant glioma it was determined apriori that the primary outcome was 6-month VTE-free survival. In order to detect a 60% VTE hazard reduction with LMWH with 80% power, 512 patients were required. Results: Recruitment began October 2002 and was closed in May 2006 because of expiration of study medication and no further re-supply. Of the 563 patients screened at 15 centers, 174 were excluded. Of the 389 eligible patients approached for consent, 186 were randomized: 99 to LMWH, 87 to placebo. Twenty-one patients developed objectively confirmed VTE during the first 6 months: 9 on LMWH and 12 on placebo (11% and 17% respectively; HR=0.7, 95% CI: 0.37–1.5, p=0.3). Over the 12 months there were 5 (5.1%) major bleeds with LMWH and 1 (1.2%) with placebo (HR=4.0, 95%CI: 0.5–34, p=0.2). All major bleeds were intracranial. Twelve-month mortality was 48% for LMWH and 45% for placebo (HR=1.2, 95%CI: 0.7–1.9, p=0.5). Conclusions: Although there was a trend in favor of the LMWH reducing VTE this was not statistically significant, likely as a result of low power. There was also a trend for increased intracranial bleeding with LMWH. Our study confirms the high incidence of thromboembolism in these patients; however, the role of long-term anticoagulant thromboprophylaxis remains unclear. Supported in part by a grant in aid from Pfizer Inc. and the Ontario Cancer Research Network. The PRODIGE steering committee thanks Terri Finch for superb administrative support. Pfizer
First Aid in Illness and Injury.
Journal: JAMA (1894)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More older patients are stuck in hospitals
Authors: David Oliver
Journal: BMJ (2016)

The UK National Audit Office (NAO) has just published the report Discharging Older Patients from Hospital .1

It focuses on the growing number of older people who are technically fit enough to leave acute hospitals in England but remain stranded. Why? Because the community services they need to support them out of hospital lack the funding, capacity, or quick response times to match their need. Such cases are officially reported as “delayed transfers of care” (DTOC).

These delays are rapidly worsening and have reached record levels.2 The NAO found that bed days due to DTOC rose by 31% from …
Treatment of depression in alcoholics
Authors: J A Shaw, P Donley, D W Morgan, J A Robinson
Journal: American Journal of Psychiatry (1975)

The authors compared two groups of depressed alcoholics given either placebo or chlordiazepoxide-imipramine in a double-blind study. Although depression decreased in both groups, there were no significant differences between them on any of three pre- and posttreament measures. The Zung scale showed that medication decreased depression significantly, however, this finding was not supported by the Beck Depression Inventory or by the Minnesota Multiphasic Personality Inventory, indicating the necessity for use of multiple assessment instruments.
Denosumab For The Treatment Of Hypercalcemia Of Malignancy Refractory To IV Bisphosphonates In Patients With Hematologic Malignancies
Authors: Rasim Gucalp, Karl Insogna, Mimi Hu, Ilya Glezerman, Sophie Leboulleux, Waldemar Misiorowski, Bennett Yu, Paul Zorsky, Diego Tosi, Alberto Bessudo, Arnaud Jaccard, Giuseppe Tonini, Wendy Ying, Ada H. Braun, Rajul K. Jain
Journal: Blood (2013)
Correcting Misconceptions About the Diagnostic Criteria for Posttraumatic Stress Disorder in<i>DSM</i>-<i>5</i>
Authors: Matthew J. Friedman, Dean G. Kilpatrick, Paula P. Schnurr, Frank W. Weathers
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal