tbuckley/cabot-search huggingface dataset:
Diet, supplements, and lifestyle factors and risk of progression in contemporary active surveillance patients.
Authors: Bruce J. Trock, Zhaoyong Feng, Patricia Landis, Ballentine Carter
Journal: Journal of Clinical Oncology (2012)

138 Background: Men diagnosed with prostate cancer frequently change their diet or lifestyle in an effort to decrease their risk of developing aggressive disease. Men managed with active surveillance (AS) may feel a greater need to modify risk factors because their cancer is untreated. However, no data on post-diagnosis diet and lifestyle factors from large prospective cohorts with long-term follow-up have been reported. We evaluated the influence of diet and lifestyle on the risk of prostate cancer biopsy progression in the largest prospective AS cohort in the US. Methods: Diet and lifestyle questionnaire completed by AS participants at enrollment. Progression determined by occurrence of Gleason score&gt;7 or increase in tumor volume at annual surveillance biopsy. Analysis focused on 28 nutrients, 10 food groups, 9 supplements, 7 medication variables, and 2 lifestyle variables with a priori hypotheses. Data were analyzed by Wilcoxen test and logistic regression, with calorie adjustment by the residual method. Results: There were 723 men in the analysis, of whom 187 (26%) progressed. Median follow-up was 2.7 years. Men who progressed were significantly older, had higher PSA density, and higher biopsy tumor burden at diagnosis. In multivariable analyses, men who progressed had higher PSA density (OR=1.34 per 0.1 ng/ml/cc, p=0.017), were more likely to have &gt;1 positive biopsy core (OR=2.9, p&lt;0.0001), had higher percentage core involved with tumor (OR=1.04, p&lt;0.0001), and were more likely to be current smokers (OR=4.1, p=0.004); duration of NSAID use and history of prostatitis approached significance. Conclusions: Cigarette smoking was significantly associated with risk of progression. This association must be viewed with caution due to the large number of variables tested. It is likely that many men considered to have progressed represent undersampling of the initial biopsy, rather than true biologic progression; this misclassification may obscure risk relationships. Ongoing analyses will be presented that explore whether associations differ for early vs late progression events. We believe this is the first report that smoking is associated with progression in men managed by AS.
Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States
Authors: Lisa A. Brown, Tamar Sofer, Adrienne M. Stilp, Leslie J. Baier, Holly J. Kramer, Ivica Masindova, Daniel Levy, Robert L. Hanson, Ashley E. Moncrieft, Susan Redline, Sylvia E. Rosas, James P. Lash, Jianwen Cai, Cathy C. Laurie, Sharon Browning, Timothy Thornton, Nora Franceschini
Journal: Journal of the American Society of Nephrology (2017)

Increased urine albumin excretion is highly prevalent in Hispanics/Latinos. Previous studies have found an association between urine albumin excretion and Amerindian ancestry in Hispanic/Latino populations. Admixture between racial/ethnic groups creates long-range linkage disequilibrium between variants with different allelic frequencies in the founding populations and it can be used to localize genes. Hispanic/Latino genomes are an admixture of European, African, and Amerindian ancestries. We leveraged this admixture to identify associations between urine albumin excretion (urine albumin-to-creatinine ratio [UACR]) and genomic regions harboring variants with highly differentiated allele frequencies among the ancestral populations. Admixture mapping analysis of 12,212 Hispanic Community Health Study/Study of Latinos participants, using a linear mixed model, identified three novel genome-wide significant signals on chromosomes 2, 11, and 16. The admixture mapping signal identified on chromosome 2, spanning q11.2-14.1 and not previously reported for UACR, is driven by a difference between Amerindian ancestry and the other two ancestries (
Large Epigastric Cystic Lesion in a Pregnant Woman
Authors: Juan A. Santamaria-Barria, Jamie Buryanek, Naruhiko Ikoma
Journal: JAMA Oncology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Obesity Is Associated with An Increased Risk of Infectious Diseases after Unrelated Bone Marrow Transplantation
Authors: Shigeo Fuji, Sung-Won Kim, Ken-ichi Yoshimura, Hideki Akiyama, Shin-ichiro Okamoto, Hiroshi Sao, Junko Takita, Naoki Kobayashi, Shin-ichiro Mori
Journal: Blood (2008)
Alloreactive Natural Killer Cells Initiate a Unique Cellular and Molecular Pathway That Greatly Accelerates Immune Reconstitution after Allogeneic Bone Marrow Transplantation
Authors: Loredana Ruggeri, Elena Urbani, Davide Chiasserini, Federica Susta, Pierluigi Orvietani, Emanuela Burchielli, Dunia Ramarli, Luciano Binaglia, Connie Jimenez, Georg A. Hollander, Andrea Velardi
Journal: Blood (2016)
Risk Factors for Developing Human Herpes Virus-6 Encephalitis and Clinical Significance of Antiviral Therapy In Early Phase After Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Ayumi Numata, Masatsugu Tanaka, Takayoshi Tachibana, Yoshiaki Ishigatsubo, Atsuo Maruta, Heiwa Kanamori
Journal: Blood (2010)
Phase I Study of Intravenous PI3K Inhibitor Bay 80–6946: Preliminary Activity in Patients with Relapsed Non-Hodgkin Lymphoma (NHL) Treated in an MTD Expansion Cohort
Authors: Amita Patnaik, Ramesh K Ramanathan, Leonard Joseph Appleman, Anthony W Tolcher, James M Mountz, Muralidhar Beerham, Glen J Weiss, Drew W Rasco, Michael T Lotze, Frederico GS Toledo, Matthew J Oborski, Prabhu Rajagopalan, Michael Jeffers, Andrea Kelly, Isabelle Genvresse
Journal: Blood (2012)
Incidence and Prognostic Factors for Infectious and Hemorrhagic Death in Patients with Acute Myeloid Leukemia: A Single-Centre Study.
Authors: Pau Montesinos, Guillermo Martin, Ninotchka Mendoza, Jesus Martinez, Federico Moscardo, Jaime Sanz, Javier de la Rubia, Isidro Jarque, Lorenzo Algarra, Guillermo Orti, Mariliz Paciello, Rosa Renart, Miguel Scaff, Susana Cantero, Mariluz Perez-Sirvent, Guillermo Sanz, Ignacio Lorenzo, Miguel Sanz
Journal: Blood (2007)
Accurate Detection of Low Mosaic Mutations Associated with Therapy Resistance in Pediatric Acute Lymphoblastic Leukemia Using Single Molecule Tagging and Deep-Sequencing
Authors: Jiangyan Yu, Simon V. van Reijmersdal, Alexander Hoischen, Edwin Sonneveld, Peter M. Hoogerbrugge, Esmé Waanders, Roland P. Kuiper
Journal: Blood (2015)
Non-Pegylated Liposomal Encapsulated Doxorubicin Reduces Cardiotoxicity in 1st Line Treatment of Diffuse Large B-Cell Lymphoma (DLBCL). Final Results of a Randomized Trial
Authors: Michael A. Fridrik, Andreas L Petzer, Felix Keil, Wolfgang Willenbacher, Ulrich Jaeger, Alois Lang, Sonja Burgstaller, Johannes Andel, Otto Krieger, Wilhelm Oberaigner, Richard Greil
Journal: Blood (2011)
The Sesquiterpene Oil α-Bisabolol Induces Apoptosis of B-Chronic Lymphocytic Leukemia Primary Cells
Authors: Massimiliano Bonifacio, Antonella Rigo, Angela Bonalumi, Emanuele Guardalben, Ilaria Nichele, Cinzia Sissa, Elisabetta Cavalieri, Christian Bergamini, Giovanni Pizzolo, Hisanori Suzuki, Fabrizio Vinante
Journal: Blood (2011)
Adalimumab (Humira (R)) is effective and safe in the treatment of rheumatoid arthritis across all participating countries in the react trial
Authors: F. Navarro-Sarabia, E. Gromnica-Ihle, L. Settas, J. W. J. Bijisma, M. McIlraith, H. Kupper
Journal: Annals of the Rheumatic Diseases (2006)
Tick tock, how long have I got?
Authors: Rebecca Coombes
Journal: BMJ (2017)

The old song tells us “Enjoy yourself, it’s later than you think.” The factors that help predict our life spans provide a clear theme in The BMJ this week. First is the (broadly) good news, from the UK Office for National Statistics: we are all living longer. A girl born in 2015 can expect to live to 83, a boy to 79. The potential causes of variation around average life expectancy are many: …
Wearable Technology and Long-term Weight Loss
Authors: Doina Kulick
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dutch and Swiss top Euro health index, with UK 15th
Authors: Rory Watson
Journal: BMJ (2017)

The Netherlands and Switzerland lead the way in providing good, consumer friendly healthcare to their citizens, as judged by the 2016 Euro health consumer index.1

The index, compiled by the Health Consumer Powerhouse, uses 48 indicators to analyse national healthcare systems in 35 European countries under six headings: patients’ rights and information, accessibility, outcomes, range and reach of services, prevention, and pharmaceuticals. The Netherlands consistently topped the index in previous years.23

Johan Hjertqvist, founder and president of Health Consumer Powerhouse, said that the findings showed that, since the …
CD4+ T regulatory cells type 1 are enriched in tumor infiltrating lymphocytes in head and neck squamous cell carcinoma
Authors: Christoph Bergmann, Laura Strauss, Stefan Lang, Reinhard Zeidler, Jonas Johnson, Theresa Whiteside
Journal: Cancer Research (2007)

1593  Objective: Tumor-infiltrating lymphocytes (TIL) in head and neck squamous cell carcinoma (HNSCC) are known to be impaired in anti-tumor immune responses. We hypothesized that this suppression could be related to accumulation and activation of regulatory T cells Type 1 (Tr1 cells) in the tumor. Therefore, we evaluated TIL for the presence and characteristics of Tr1 cells and compared them to Tr1 cells in the peripheral blood of HNSCC patients.  Methods: To generate Tr1 cells, an in vitro culture system containing MACS-separated CD4+CD25- T cells, which were obtained either from TIL or the peripheral blood of 15 HNSCC patients, was used. Lymphocytes were cultured in AIM V medium supplemented with low doses of IL-2, IL-10, IL-15 and 10% FBS for 10 days. In parallel, CD4+CD25- T cells isolated from the peripheral blood of 10 normal donors were cultured in the presence of irradiated HLA-A2+ HNSCC cells, autologous immature dendritic cells and the same cytokines to simulate tumor microenvironment and serve as controls. Multi-color flow cytometry was used to phenotype freshly isolated and outgrowing cells stained for CD25, CD122, CD132, FoxP3, CTLA-4, IL-10 and IL-4. Their suppressor activity was measured in CFSE inhibition assays using autologous OKT3-stimulated CD4+CD25- responders. Culture supernatants (SN) were tested for levels of cytokines in ELISA.  Results: In HNSCC patients, freshly isolated CD4+CD25- TIL contained 67% IL-4+, 25% IL-10+ and 20% each Foxp3+ and CTLA-4+ T cells. After culture the phenotype of outgrowing T cells corresponded to that of Tr1 cells: low expression of Foxp3 (2.5% ± 3, MFI: 3.8 ± 1) and CTLA-4 (2.1% ± 1, 2.4 ± 1.4) and high expression of IL-10 (88.4% ± 5.1, MFI: 13.5 ± 2.6) and IL-2Rγ (56.2% ± 12, MFI: 195.9 ± 33.1). Tr1 cells outgrowing from PBMC had lower MFI for IL-10 and IL2R γ (p=0.0001). The suppressor activity of Tr1 cells obtained from TIL was higher than that of Tr1 cells expanded from PBMC (85.1% ± 9.7 vs. 64.8% ± 14.5). Levels of IL-10 and TGF-β1 in culture SN of TIL was significantly higher compared to levels in SN of PBMC cultures (median: 1429pg/mL vs. 1023 pg/mL and median: 3721pg/mL vs. 3006pg/mL, respectively). In normal control cultures, outgrowing Tr1 cells were fewer and had lower suppressor activity. Conclusion: Phenotypically and functionally, Tr1 cells in TIL are different from circulating Tr1 cells in HNSCC patients. Tr1 cells with high suppressor activity are enriched in the tumor microenvironment and may contribute to the impairment of anti-tumor immune responses.
“Unfairness” of locums’ higher pay must be tackled, says NHS chief
Authors: Gareth Iacobucci
Journal: BMJ (2017)

The NHS must work harder to balance doctors’ desire for flexible working with the “intrinsic unfairness” of locum doctors earning substantially higher rates of pay than their staff colleagues, the head of NHS England has told The BMJ .

Simon Stevens said that although he was not advocating “complete rigidity” of working practices, he was concerned that the NHS workforce had become too “casualised,” akin to the app based taxi firm Uber.

The NHS introduced a cap on locum …
Comprehensive Risk Factor Analysis in 939 Adults with Acute Myeloid Leukemia Receiving Risk Stratified Post-Remission Therapy: Results of the Prospective Randomized AML96 Trial of the German Study Initiative Leukemia (DSIL).
Authors: Gerhard Ehninger, Martin Bornhaeuser, Christian Thiede, Walter E. Aulitzky, Heinrich Bodenstein, Bernd Dorken, Hermann Einsele, Martin Gramatzki, Mathias Hanel, Gisela Helm, Anthony D. Ho, Andreas Jakob, Ulrich Krumpelmann, Lothar Leimer, Hartmut Link, Stefan Mahlmann, Andreas Neubauer, Karl-Heinz Pfluger, Mathias Sandmann, Kerstin Schafer-Eckart, Norbert Schmitz, Ulrich S. Schuler, Silke Soucek, Reingard Stuhlmann, Hans-Joachim Tischler, Thomas Wagner, Hannes Wandt, Thomas Illmer, Markus A. Schaich
Journal: Blood (2007)
CD30-Targeted Therapy with Brentuximab Vedotin Combined with Donor Lymphocyte Infusions Induce Sustained Clinical Remissions and Tumor Specific Immunity in a Series of Patients with Relapsed Hodgkin Lymphoma After Allogeneic Stem Cell Transplantation
Authors: Sebastian Theurich, Joke Malcher, Kerstin Wennhold, Alexander Shimabukuro-Vornhagen, Jens M. Chemnitz, Holtick Udo, Anke Krause, Carsten Kobe, Deniz Kahraman, Chakupurakal Geothy, Andreas Engert, Scheid Christof, Michael Hallek, Michael von Bergwelt-Baildon
Journal: Blood (2012)
The Gene Expressions of hOCT1 and ABCB1 Change During the Course of CML in Relation to Imatinib Therapy
Authors: Katerina Machova Polakova, Jitka Koblihova, Zuzana Ondrackova, Filip Razga, Vaclava Polivkova, Hana Klamova, Daniela Zackova, Petr Cetkovsky, Marek Trneny, Jiri Mayer, Zdenek Racil
Journal: Blood (2011)
Upregulation of FLIPs upon CD40 Stimulation - A Novel Inhibititory Mechanism of CD95-Induced Apoptosis in Precursor B-ALL Blasts in Children.
Authors: Anja Troeger, Ingo Schmitz, Ludmila Glouchkova, Meinolf Siepermann, Gritta Janka-Schaub, Klaus Schulze-Osthoff, Dagmar Dilloo
Journal: Blood (2005)
E-cigarettes attract low risk adolescents to smoking, say researchers
Authors: Jacqui Wise
Journal: BMJ (2017)

Electronic cigarettes can encourage young people to smoke and to consume nicotine and are expanding the tobacco market, warn the authors of a large US study published in the journal Pediatrics .1

The study examined data from more than 140 000 middle and high school students who completed the Centers for Disease Control and Prevention’s national youth tobacco survey from 2004 to 2014.

Current smoking among adolescents decreased from 15.8% in 2004 to 6.4% in 2014. However, the decline in cigarette smoking did not accelerate …
A Pilot Study of Efficacy of Lactobacillus CD2 Lozenges in Preventing High-Dose Chemotherapy Induced Oral Mucositis in Patients Undergoing Haematopoietic Stem Cell Transplantation
Authors: Atul Sharma, Tilak Tvsvgk, Vinod Raina, Lalit Kumar, Sameer Bakhshi, Surendra Pal Chaudhary, Ranjit Kumar Sahoo
Journal: Blood (2012)
T Cell Trafficking in Acute GVHD: In Vivo Bioluminescence Evaluation To Elucidate the Role of Different Lymphatic Organs.
Authors: Andreas Beilhack, Stephan Schulz, Jeanette Baker, Georg F. Beilhack, Courtney B. Wieland, Enosh M. Baker, Edward I. Herman, Gilad Landan, Janelle A. Kime, Yu-An Cao, Christopher H. Contag, Robert S. Negrin
Journal: Blood (2004)
Fludarabine, Cyclophosphamide and Rituximab (FCR) Related Prolonged Cytopenia Is Frequent and Adverse Factor Affecting Survival of Patients with Chronic Lymphocytic Leukemia (CLL)
Authors: Petra Obrtlikova, Anna Jonasova, Magda Siskova, Eduard Cmunt, Adela Berkova, Josef Karban, Katerina Svackova, Marek Trneny
Journal: Blood (2012)
Compassionate Use of Combined Anti-Inflammatory and Angiostatic Treatment as Third-Line Therapy in Eight Patients with Multiple Myeloma – a Combined Treatment Setting of Lenalidomide with Pioglitazone, Dexamethasone and Low-Dose Treosulfan.
Authors: Albrecht Reichle, Martin Vogelhuber, Ernst Holler, Joachim Hahn, Reinhard Andreesen
Journal: Blood (2009)
Interim Analysis of a Phase II Trial of Bortezomib in Patients with Multiple Myeloma Who Failed To Achieve a Complete Response to Autologous Peripheral Blood Stem Cell Transplantation.
Authors: Robert M. Rifkin, Roy A. Beveridge, Mark W. Brunvand, Gary Spitzer, Boehm A. Kristi, Mary Ann Rauch, Feng Zhan, Lina Asmar
Journal: Blood (2005)
Anti-Myeloma Activity of the Small-Molecule Aurora Kinase Inhibitor VE465.
Authors: Joseph M. Negri, Douglas W. McMillin, Nicholas Mitsiades, Teru Hideshima, Dharminder Chauhan, Yu-Tzu Tai, Xavier Leleu, Nikhil C. Munshi, Paul G. Richardson, Carolyn A. Buser-Doepner, John Pollard, Kenneth C. Anderson, Constantine S. Mitsiades
Journal: Blood (2006)
Oxidative Stress and Increased Destruction of Red Blood Cells Contribute to the Pathophysiology of Anemia Caused By DMT1 Deficiency
Authors: Zuzana Zidova, Daniel Garcia-Santos, Katarina Kapralova, Pavla Koralkova, Renata Mojzikova, Dalibor Dolezal, Prem Ponka, Vladimir Divoky, Monika Horvathova
Journal: Blood (2014)
Monitoring dynamic arterial elastance as a means of decreasing the duration of norepinephrine treatment in vasoplegic syndrome following cardiac surgery: a prospective, randomized trial
Authors: Pierre-Grégoire Guinot, Osama Abou-Arab, Mathieu Guilbart, Stéphane Bar, Elie Zogheib, Mona Daher, Patricia Besserve, Joseph Nader, Thierry Caus, Said Kamel, Hervé Dupont, Emmanuel Lorne
Journal: Intensive Care Medicine (2017)
Bone Marrow Biopsy Revision According to WHO Criteria in 272 Patients of the Registro Italiano Trombocitemia (RIT): Preliminary Report On Clinical and Histopathological Implications.
Authors: Luigi Gugliotta, Stefano Ascani, Silvia Asioli, Emanuela Boveri, G. Fraternali Orcioni, Umberto Gianelli, Elena Sabattini, Francesco Passamonti, Franca Radaelli, Alessia Tieghi, Claudio Tripodo, Riccardo Valli, Nicola Vianelli, Vito Franco
Journal: Blood (2009)
Increased Circulating Soluble Lectin-Like Oxidized Low-Density Lipoprotein Receptor (sLOX-1) and Increased Endothelial Cell Expression of LOX-1 in Sickle Cell Disease (SCD): A Novel Marker for SCD Vasculopathy?
Authors: Mingyi Chen, Xin Lin, Hannah Archibald, Ted Wun, Ralph Green
Journal: Blood (2012)
Incidence and Clinical Features of Core Binding Factor Acute Myeloid Leukemia: A Collaborative Study of the Japan Adult Leukemia Study Group and the Korean Society of Hematology.
Authors: Tomohiko Taki, Hee-Je Kim, Shigeki Ohtake, Byung-Sik Cho, Hitoshi Kiyoi, Woo-Sung Min, Norio Asou, So-Young Choi, Yasushi Miyazaki, Yeo-Kyeoung Kim, Hisashi Sakamaki, June-Won Cheong, Sumihisa Honda, Shuichi Miyawaki, Masafumi Taniwaki, Hyeoung-Joon Kim, Tomoki Naoe, Yoo-Hong Min
Journal: Blood (2012)
Internet Cognitive Behavior Therapy Effective as Insomnia Treatment
Authors: Anita Slomski
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal