tbuckley/cabot-search huggingface dataset:
Economic evaluation of sorafenib vs. best supportive care in hepatocellular carcinoma
Authors: N. Muszbek, S. Shah, S. M. Carroll, B. I. Carr, K. Gondek
Journal: Journal of Clinical Oncology (2008)

6527 Background: A randomized phase III trial of sorafenib vs. placebo in hepatocellular carcinoma (SHARP study) demonstrated that sorafenib significantly prolonged overall survival (OS) compared to placebo (median OS = 324 days [95% CI: 286–405] vs. 241 days [95% CI: 206–276]; p<0.001). Sorafenib is the first and only systemic agent to demonstrate survival benefit over the past 30 years. Given the clinical significance of these results, the objective of this study was to demonstrate the cost-effectiveness associated with sorafenib compared to best supportive care (BSC) from the US third party payer perspective. Methods: A Markov model was developed to evaluate the cost-effectiveness of sorafenib vs. BSC. The model followed survival and time to progression (TTP) in monthly cycles based on the extrapolation of patient level trial data over a patient's lifetime. Health effects were expressed as life years gained (LYG). Resource use included drugs, physician visits, laboratory tests, scans, hospitalizations and treatment of adverse events. Unit costs were gathered from diagnosis related groupings, Medicare charges and the Red Book and were expressed in 2007 US Dollars. Costs and effects were evaluated over a lifetime and discounted at 3%. Results were presented as incremental cost/LYG. Deterministic and probabilistic sensitivity analyses were conducted. Results: LYG was longer for sorafenib compared to BSC (1.59±0.18 vs. 1.06±0.10 LYG/patient for sorafenib and BSC, respectively). The lifetime total costs were $41,782±3,292 for sorafenib and $8,161±1,408 for BSC. The results indicated an incremental cost-effectiveness ratio of $64,301/LYG. The key drivers of the model results were OS, TTP and BSC costs after progression. Sensitivity analyses results showed that the model was robust. Conclusions: The economic evaluation indicates that sorafenib is cost-effective as compared to BSC, with cost-effectiveness ratios within the established threshold that society is willing to pay (i.e. $50,000- $100,000). Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Bayer Bayer
Malignant tumors in patients with human immunodeficiency virus infection: a report of 580 cases.
Authors: U Tirelli, A Carbone, S Monfardini, A Lazzarin, E Alessi, S Pileri
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.10.1582 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2778488 Malignant tumors in patients with human immunodeficiency virus infection: a report of 580 cases. U TirellixU TirelliSearch for articles by this author , A CarbonexA CarboneSearch for articles by this author , S MonfardinixS MonfardiniSearch for articles by this author , A LazzarinxA LazzarinSearch for articles by this author , E AlessixE AlessiSearch for articles by this author , S PilerixS PileriSearch for articles by this author https://doi.org/10.1200/JCO.1989.7.10.1582 PDF "Malignant tumors in patients with human immunodeficiency virus infection: a report of 580 cases.." Journal of Clinical Oncology, 7(10), pp. 1582–1583© 1989 by American Society of Clinical Oncology
The Eight
Authors: Jeanette M. Smith
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Uptake and impact of vaccinating school age children against influenza during a season with circulation of drifted influenza A and B strains, England, 2014/15
Authors: Richard G Pebody, Helen K Green, Nick Andrews, Nicola L Boddington, Hongxin Zhao, Ivelina Yonova, Joanna Ellis, Sophia Steinberger, Matthew Donati, Alex J Elliot, Helen E Hughes, Sameera Pathirannehelage, David Mullett, Gillian E Smith, Simon de Lusignan, Maria Zambon
Journal: Eurosurveillance (2015)

The 2014/15 influenza season was the second season of roll-out of a live attenuated influenza vaccine (LAIV) programme for healthy children in England. During this season, besides offering LAIV to all two to four year olds, several areas piloted vaccination of primary (4–11 years) and secondary (11–13 years) age children. Influenza A(H3N2) circulated, with strains genetically and antigenically distinct from the 2014/15 A(H3N2) vaccine strain, followed by a drifted B strain. We assessed the overall and indirect impact of vaccinating school age children, comparing cumulative disease incidence in targeted and non-targeted age groups in vaccine pilot to non-pilot areas. Uptake levels were 56.8% and 49.8% in primary and secondary school pilot areas respectively. In primary school age pilot areas, cumulative primary care influenza-like consultation, emergency department respiratory attendance, respiratory swab positivity, hospitalisation and excess respiratory mortality were consistently lower in targeted and non-targeted age groups, though less for adults and more severe end-points, compared with non-pilot areas. There was no significant reduction for excess all-cause mortality. Little impact was seen in secondary school age pilot only areas compared with non-pilot areas. Vaccination of healthy primary school age children resulted in population-level impact despite circulation of drifted A and B influenza strains.
Case 26-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Sheldon D. Kaufman, W. Stephen Black-Schaffer
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 70-year-old man was admitted to the hospital because of lethargy and anorexia.There was a long history of alcohol abuse and heavy smoking. Sixteen years before admission diagnoses of fatty liver and Wernicke-Korsakoff syndrome were made. Two years before entry he noticed swelling in the right cervical region. A barium-swallow study was negative. A biopsy specimen of the mass was interpreted at another hospital as a benign lesion. Fourteen months before admission a left cervical mass appeared and enlarged rapidly. Ten months before entry he came to this hospital, where an enlarged left cervical lymph node . . .
Loss of epithelial FAM20A in mice causes amelogenesis imperfecta, tooth eruption delay and gingival overgrowth
Authors: Li-Li Li, Pei-Hong Liu, Xiao-Hua Xie, Su Ma, Chao Liu, Li Chen, Chun-Lin Qin
Journal: International Journal of Oral Science (2016)

FAM20A has been studied to a very limited extent. Mutations in human FAM20A cause amelogenesis imperfecta, gingival fibromatosis and kidney problems. It would be desirable to systemically analyse the expression of FAM20A in dental tissues and to assess the pathological changes when this molecule is specifically nullified in individual tissues. Recently, we generated mice with a Fam20A-floxed allele containing the beta-galactosidase reporter gene. We analysed FAM20A expression in dental tissues using X-Gal staining, immunohistochemistry and in situ hybridization, which showed that the ameloblasts in the mouse mandibular first molar began to express FAM20A at 1 day after birth, and the reduced enamel epithelium in erupting molars expressed a significant level of FAM20A. By breeding K14-Cre mice with Fam20A(flox/flox) mice, we created K14-Cre;Fam20A(flox/flox) (conditional knock out, cKO) mice, in which Fam20A was inactivated in the epithelium. We analysed the dental tissues of cKO mice using X-ray radiography, histology and immunohistochemistry. The molar enamel matrix in cKO mice was much thinner than normal and was often separated from the dentinoenamel junction. The Fam20A-deficient ameloblasts were non-polarized and disorganized and were detached from the enamel matrix. The enamel abnormality in cKO mice was consistent with the diagnosis of amelogenesis imperfecta. The levels of enamelin and matrix metalloproteinase 20 were lower in the ameloblasts and enamel of cKO mice than the normal mice. The cKO mice had remarkable delays in the eruption of molars and hyperplasia of the gingival epithelium. The findings emphasize the essential roles of FAM20A in the development of dental and oral tissues.
A Case of Meigs's Syndrome
Authors: C. Nwokolo
Journal: BMJ (1952)

JOR&ment for this complication has yet to be decided.In the other two patients the prosthesis is apparently wedded to the bone as a result of more rigid fixation, and it may ;e that the marriage will be a long and happy one.Wholly metallic (Moore and Bohlman, 1943; Loomis, 1950) and wholly plastic prostheses similar to ours (Hudack, 1951 ; Scales, 1951) have proved satisfactory replacements for segments of bone, but the relative merits of the two materials have yet to be evaluated.A judicious combination of the two materials is best in order to achieve the optimum of lightnes and strength. SummaryBone resection and replacement by internal prosthesis, are advocated for endosteal tumours of low malignancy.The early results in three cases are reported.The relative merits of amputation and resection are discussed.The first patient's prosthesis was made by the dental school of the University of Leeds, the prostheses of the second and third patients by Messrs. Down Bros.It is a pleasure to thank Pro- fessor T. Read, of the University of Leeds, and Mr. V. Carter, of Down Bros., for the help they have given us with the designing and oonstruction of these prostheses.We also wish to thank
What Has Become of the Cuspidor?
Authors: E. J. H.
Journal: Annals of Internal Medicine (1964)

Editorial1 January 1964What Has Become of the Cuspidor?E. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-60-1-163 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPhysicians who conclude that the statistical association between cigarette smoking and lung cancer represents a causal relation must conclude, if only in conscience, that they should help to erase the smoking of cigarettes. Their strategy must be picked carefully. Their campaign, if collective, would be strongly resisted. The tobacco society—all those who profit in coin from the habit—planters, brokers, manufacturers, advertisers—would surely fight back. The more massive, though passive, resistance would be the inertia of the smokers—all those who repeatedly seek for and suck momentary relief from tension and anxiety at the cost of future risks.Knowledgeas a weapon?...References1. Smoking and Health. Summary and Report of the Royal College of Physicians of London on Smoking in Relation to Cancer of the Lung and Other Diseases. Pitman Publishing Corporation, New York, 1962, p. 11. Google Scholar2. LYNES R: The Tastemakers, Harpers, New York, 1954. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byA Tribute to Edward Huth, EditorJohn R. Ball, MD, JD 1 January 1964Volume 60, Issue 1Page: 163-164KeywordsAnxietyForecastingLung and intrathoracic tumors Issue Published: 1 January 1964 PDF downloadLoading ...
Practical Surgery Illustrated.
Journal: JAMA (1925)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P2-149: Prognostic value of telomerase activity in transthoracic fine-needle biopsy aspirates from non-small cell lung cancer
Authors: Tomasz Targowski, Karina Jahnz-Rozyk, Tomasz Szkoda, Naim Qandil, Slawomir From, Tadeusz Plusa
Journal: Journal of Thoracic Oncology (2007)
Integration of G-Protein Coupled Receptor Signaling Pathways for Activation of a Transcription Factor (EGR-3)
Authors: Xuehai Tan, Pam Sanders, Jack Bolado, Mike Whitney
Journal: Genomics Proteomics & Bioinformatics (2003)

Abstract We recently reported the use of a gene-trapping approach to isolate cell clones in which a reporter gene had integrated into genes modulated by T-cell activation. We have now tested a panel of clones from that report and identified the one that responds to a variety of G-protein coupled receptors (GPCR). The β-lactamase tagged EGR-3 Jurkat cell was used to dissect specific GPCR signaling in vivo. Three GPCRs were studied, including the chemokine receptor CXCR4 (Gi-coupled) that was endogenously expressed, the platelet activation factor (PAF) receptor (Gq-coupled), and β2 adrenergic receptor (Gs-coupled) that was both stably transfected. Agonists for each receptor activated transcription of the β-lactamase tagged EGR-3 gene. Induction of EGR-3 through CXCR4 was blocked by pertussis toxin and PD58059, a specific inhibitor of MEK (MAPK/ERK kinase). Neither of these inhibitors blocked isoproterenol or PAF-mediated activation of EGR-3. Conversely, β2- and PAF-mediated EGR-3 activation was blocked by the p38, specific inhibitor SB580. In addition, both β2- and PAF-mediated EGR-3 activation could be synergistically activated by CXCR4 activation. This combined result indicates that EGR-3 can be activated through distinct signal transduction pathways by different GPCRs and that signals can be integrated and amplified to efficiently tune the level of activation.
Transference interpretations in focal therapy
Authors: A Frances, S Perry
Journal: American Journal of Psychiatry (1983)

There are three contradictory positions regarding the usefulness of transference interpretations in focal therapy: they are 1) indispensable, 2) to be avoided, or 3) not important compared with nonspecific therapeutic factors. After a review of the rationale and the uncompelling research supporting each position, the authors suggest tentative indications for transference interpretation in focal therapy and illustrate these with two cases.
Smoking cessation in patients with HIV.
Authors: R E Chaisson
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Ensembl Variant Effect Predictor
Authors: William McLaren, Laurent Gil, Sarah E. Hunt, Harpreet Singh Riat, Graham R. S. Ritchie, Anja Thormann, Paul Flicek, Fiona Cunningham
Journal: Genome biology (2016)

The Ensembl Variant Effect Predictor is a powerful toolset for the analysis, annotation, and prioritization of genomic variants in coding and non-coding regions. It provides access to an extensive collection of genomic annotation, with a variety of interfaces to suit different requirements, and simple options for configuring and extending analysis. It is open source, free to use, and supports full reproducibility of results. The Ensembl Variant Effect Predictor can simplify and accelerate variant interpretation in a wide range of study designs.
Immunodiffusion Studies of Lymphoblast Cell Antigens
Authors: David A. Stevens
Journal: JNCI Journal of the National Cancer Institute (1975)

Immunodiffusion Studies of Lymphoblast Cell Antigens David A. Stevens, M. D. David A. Stevens, M. D. Santa Clara Valley Medical Center and Stanford University San Jose and StanfordCalifornia Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 2, August 1975, Page 229, https://doi.org/10.1093/jnci/55.2.229 Published: 01 August 1975
Direct Thrombin Inhibitors
Authors: J P Maffrand
Journal: New England Journal of Medicine (2005)

Thrombin not only plays an important role in thrombosis and haemostasis but may also be involved in other pathological situations such as the progression of atherosclerotic plaque formation, inflammatory response and neurodegenerescence. It is therefore important to be able to control the action and/or the generation of this enzyme. With this aim in view, a great number of synthetic or recombinant direct thrombin inhibitors have recently been made. They block either the thrombin catalytic site or an anion-binding exosite which is a recognition site for some of its substrates (fibrinogen, thrombin receptor, thrombomodulin, heparin cofactor II) or act on both sites. Some of these inhibitors have revealed a number of advantages over heparin in experimental animal models of thrombosis and haemorrhagic risk. On-going clinical studies with some candidates will establish their real interest for patients.
Mental health expenditures in California counties
Authors: L M Koran, K Meinhardt
Journal: American Journal of Psychiatry (1981)

In 1957 California began placing responsibility for public mental health services on county programs still vary widely in emphasis and size. The authors explored determinants of counties' unequal program developments using per capita expenditures as the measure of county services. Sociodemographic variables that help explain states' social program expenditures correlate weakly or not at all with county mental health expenditures. The most powerful predictor of these expenditures is number of psychiatrists per 10,000 population. Equal per capita expenditures, however, are not a reasonable goal; these can mask wide variations in program content, efficiency, and quality of care.
Social rehabilitation of separation-induced depressive disorders in monkeys
Authors: S J Suomi, R Delizio, H F Harlow
Journal: American Journal of Psychiatry (1976)

The authors studied a group of four monkeys reared together, repeatedly separated from each other, and then exposed to another group of four monkeys reared in surrogate-peer groups who acted as therapists. The study group was compared with the therapist monkeys, a group exposed to the same separations but not to the therapist monkeys, a control group that experienced no separations, and two additional groups of stimulus animals. The authors' findings indicate that monkeys showing depressive begaviors after repeated separations can be returned to age-appropriate social performance through repeated exposure to socially active age-mates.
EMCDDA publishes guidelines on testing for HIV, viral hepatitis and other infections in injecting drug users
Authors: L Wiessing, H Blystad
Journal: Eurosurveillance (2010)

Preview this article: EMCDDA publishes guidelines on testing for HIV, viral hepatitis and other infections in injecting drug users, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/48/art19735-en-1.gif
Soundings: Escape to Eden
Authors: George Dunea
Journal: BMJ (2001)

The aeroplane is speeding west towards the City of Eden. I sit in an exit row; plenty of legroom, but the footrest won't go up. On my right, two lovebirds: same sweaters, same laptops, same spreadsheets. Across the aisle, two women: one, enormously fat, can hardly fit into her seat. The other has talked for hours without taking a breath: has high blood pressure; takes aspirin and herbs; blood pressure is 140/90, but she does not remember which number should be on top; has a gadget to take blood pressures; the nurse cannot even feel her pulse; thinks the instrument is faulty.