tbuckley/cabot-search huggingface dataset:
Phase II window therapy.
Authors: R J Wells
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.1.302 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7865002 Phase II window therapy. R J WellsxR J WellsSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.1.302 PDF "Phase II window therapy.." Journal of Clinical Oncology, 13(1), pp. 302–303© 1995 by American Society of Clinical Oncology
Characteristics of Decedents in Medicare Advantage and Traditional Medicare
Authors: Elena Byhoff, John A. Harris, John Z. Ayanian
Journal: JAMA Internal Medicine (2016)

Methods | Waiver for this study was obtained through Alberta Health Services for collection of aggregate data.Based on these various sources of recommendations, a guideline was formed (Box) and was approved by Alberta Health Services.This guideline led to a separate form being developed and issued by laboratory services.Physicians now had to identify the indication for testing vitamin D levels.Indications other than those identified in the guideline did not allow for testing of vitamin D levels.This new requisition was implemented on April 1, 2015.Before this date, for several years, the number of annual 25-hydroxy vitamin D assays was approximately 310 000 per year (ie, 1 in 14 Albertans).We measured the monthly number of vitamin D order requests before and after introducing a new procedure for ordering tests.Results | From April 1 to December 31, 2015, subsequent to the creation of a new ordering form, 20 609 vitamin D tests were ordered.During this 9-month period, one would have expected, based on historical data, that 256 027 tests would have been ordered.This intervention thus led to a 92.0%reduction in the number of vitamin D tests ordered, a savings of about $4 million USD per year ($3 million in the period studied thus far) (Figure).Although criteria-based interventions are susceptible to methods that manage to avoid adhering to the requirements, a rebound in test ordering has not been observed 9 months after implementation.Our laboratory ordering system is both paper-based and electronic; thus, this type of intervention can be used in many different systems.Discussion | Criteria-based approaches to the implementation of the Choosing Wisely recommendations have been examined in practice for other tests, including the commonly ordered tests for rheumatoid factor antibody and anti-nuclear antibodies, as well as advanced imaging (computed tomographic scan, bone scan, or magnetic resonance imaging) for spinal pain. 5,6 Using a criteria-based approach to test ordering not only reduces the number of tests that would be ordered but it does so without missing clinically relevant conditions.
Opiate use and sexual function
Authors: S M Mirin, R E Meyer, J H Mendelson, J Ellingboe
Journal: American Journal of Psychiatry (1980)

Although opiate addicts often equate the drug experience with sexual orgasm, diminished libido and impaired sexual performance are common sequelae of chronic use. Early clinical studies suggested that opiates may interfere with sex hormone secretion. The authors carried out three sequential studies which demonstrated that heroin use in man results in acute suppression of luteinizing hormone (LH) release from the pituitary followed by a secondary drop in plasma testosterone levels. The time course of these neuroendocrine events correlates well with the tension-reducing effects of heroin and suggests that drive reduction is an important component of opiate reinforcement.
Proteomics Reveals that Proteins Expressed During the Early Stage of <i>Bacillus Anthracis</i> Infection are Potential Targets for the Development of Vaccines and Drugs
Authors: Chun-Ming Huang, Craig A. Elmets, De-chu C. Tang, Fuming Li, Nabiha Yusuf
Journal: Genomics Proteomics & Bioinformatics (2004)

In this review, we advance a new concept in developing vaccines and/or drugs to target specific proteins expressed during the early stage of Bacillus anthracis (anthrax) infection and address existing challenges to this concept. Three proteins (immune inhibitor A, GPR-like spore protease, and alanine racemase) initially identified by proteomics in our laboratory were found to have differential expressions during anthrax spore germination and early outgrowth. Other studies of different bacillus strains indicate that these three proteins are involved in either germination or cytotoxicity of spores, suggesting that they may serve as potential targets for the design of anti-anthrax vaccines and drugs.
PWE-371 Clinical outcomes of patients undergoing laparoscopic vs open surgery for rectal cancers
Authors: S Sinukumar, JL Menezes, A Desouza, A Saklani
Journal: Gut (2015)

<h3>Introduction</h3> Laparoscopic resection of rectal cancer has been approached with caution, especially after chemoradiation, in view of the results of the MRC CLASICC trial. Two more recent trials, the COREAN trial and the COLOUR II trial, show equivalent results with laparoscopic and open resection of the rectum. We evaluated the perioperative and short term oncological results of a consecutive series of unselected patients with operable rectal cancer treated open or laparoscopic proctectomy in a one-year period. <h3>Method</h3> All patients with rectal cancer operated at the specialist colorectal unit in the one-year period from July 2013 to June 2014 were evaluated. Patients with inoperable disease at laparoscopy/ laparotomy or those who underwent pelvic exenteration were excluded from the study. 258 consecutive unselected patients of operable rectal cancer, who underwent potentially curative resection of the rectum (laparoscopic or open) during the study period were included in the study. Data was obtained from a prospectively maintained database and analysed. <h3>Results</h3> Eight three patients underwent laparoscopic and 175 patients underwent open resection of the tumours, depending on availability of laparosopic instruments in the operation theatre. Adenocarcinoma was the most common histology (92%). Median distance of the lower edge of the tumour from the anal verge was 5cm in both groups. The majority (87.5%) of the tumours were staged either cT3+ (74%) or cN+ (72%) or both at initial staging. Overall, 64% of patients received pre-operative radiotherapy. Mean BMI of patients was 23. The overall sphincter preservation rate was 70% (73% in open group and 64% in laparoscopic group which may be the result of a larger fraction of tumours within 5cm of the anal verge in the laparoscopic group). The overall blood loss was lower in laparoscopic group (median 200mL) than open group (median 500mL). The postoperative stay was only slightly lower in the laparoscopic group (mean 7.3 days) than open group (mean 8.4 days). CRM positivity was similar in both groups (3.6% laparoscopic versus 4% open group). Median nodal harvest was similar in both groups (12 nodes). <h3>Conclusion</h3> Laparoscopic resection of the rectum is at least as good as open resection for rectal cancer with similar short-term oncological outcomes and improved perioperative outcomes. <h3>Disclosure of interest</h3> None Declared.
Toxicity of adjuvant therapy for resected locally advanced non-small-cell lung cancer.
Authors: B W Corn, W J Curran
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.8.1355 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2842465 Toxicity of adjuvant therapy for resected locally advanced non-small-cell lung cancer. B W CornxB W CornSearch for articles by this author , W J Curran JrxW J Curran JrSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.8.1355 PDF "Toxicity of adjuvant therapy for resected locally advanced non-small-cell lung cancer.." Journal of Clinical Oncology, 6(8), p. 1355© 1988 by American Society of Clinical Oncology
Vitamin D and Cardiometabolic Outcomes: A Systematic Review
Authors: Anastassios G. Pittas, Mei Chung, Thomas Trikalinos, Joanna Mitri, Michael Brendel, Kamal Patel, Alice H. Lichtenstein, Joseph Lau, Ethan M. Balk
Journal: Annals of Internal Medicine (2010)

Background
Vitamin D may modify risk of cardiometabolic outcomes (type 2 diabetes, hypertension, or cardiovascular disease).
Racial intolerance in a correctional institution: an ecological view
Authors: A Pfefferbaum, N I Dishotsky
Journal: American Journal of Psychiatry (1981)

To determine the significance of social factors in racial intolerance, the authors studied the relationship between relational behavior and ethnicity, group status and role, peer acceptance, and group cohesion in an adolescent correctional institution. Results portray three distinct patterns of adaptation. Hispanics (Chicanos) formed a highly cohesive group that required considerable conformity to group norms; policy was implemented by a leadership capable of relating well to all ethnic groups. Whites formed a disorganized and fragmented group, led by individuals who engaged in racially antagonistic behavior. The highly cohesive black group and their leadership were simultaneously in the forefront of both racial cooperation and racial conflict.
HLA-A Gene Polymorphism Defined by High-Resolution Sequence-Based Typing in 161 Northern Chinese Han People
Authors: Chunxia Yan, Ruilin Wang, Jingxiang Li, Yajun Deng, Dongying Wu, Hongbo Zhang, Hongxing Zhang, Lidong Wang, Chunrong Zhang, Haiyan Sun, Xiuqing Zhang, Jian Wang, Huanming Yang, Shengbin Li
Journal: Genomics Proteomics & Bioinformatics (2003)

Abstract Human leukocyte antigen (HLA) system is the most polymorphic region known in the human genome. In the present study, we analyzed for the first time the HLA-A gene polymorphisms defined by the high-resolution typing methods—sequence-based typing (SBT) in 161 Northern Chinese Han people. A total of 74 different HLA-A gene types and 36 alleles were detected. The most frequent alleles were A*110101 (GF=0.2360), A*24020101 (GF=0.1646), and A*020101 (GF=0.1553); followed by A*3303 (GF=0.1180), A*3001 (GF=0.0590), and A*310102 (GF=0.0404). The frequencies of following alleles, A*0203, A*0205, A*0206, A*0207, A*030101, A*2423, A*2601, A*3201, and A*3301, are all higher than 0.0093. The homozygous alleles include A*020101, A*110101, A*24020101 and A*310102. Heterozygosity (H), polymorphism information content (PIC), discrimination power (DP) and probability of paternity exclusion (PPE) of HLA-A in the samples were calculated and their values were 0.8705, 0.8491, 0.6014, and 0.9475, respectively. These results by SBT analysis of HLA-A polymorphism in Northern Chinese Han population, especially the allele subtypes character, will be of great interest for clinical transplantation, disease-associated study and forensic identification. Implementation of high-resolution typing methods allows a significantly wider spectrum of HLA variation including rare alleles. This spectrum will further be extensively utilized in many fields.
THU0500 Soluble TAM (TYRO3, AXL, MER) Receptors and GAS6 Ligand in Patients with Juvenile Systemic Lupus Erythematosus (JSLE): Table 1.
Authors: B.L. Liphaus, P. Palmeira, L. Lima, C.A. Silva, C. Goldenstein-Schainberg, M. Carneiro-Sampaio
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> TAM (Tyro3, Axl, Mer) kinases receptors and Gas6 ligand are pivotal regulators of innate immunity and responsible for the clearance of apoptotic cells. TAM receptors and Gas6 ligand were individually tested in adult onset lupus with different results.<sup>1-5</sup> <h3>Objectives</h3> To quantify simultaneously soluble TAM receptors and Gas6 ligand in JSLE patients and evaluated the relation with disease activity parameters. <h3>Methods</h3> sTyro3, sAxl, sMer and Gas6 ligand were measured in sera from 44 JSLE patients (39 girls, mean age 14.2 yrs, ACR criteria), 14 gender and age-matched healthy individuals (11 girls, mean age 13.9 yrs) and 9 JIA patients as disease controls (4 girls, mean age 10.5, ACR criteria). Soluble TAM receptors and Gas6 ligand were quantified by commercial ELISA Kits following manufacturer9s instructions. Disease activity parameters included SLEDAI score, anti-dsDNA (ELISA), C3 and C4 (nephelometry), ERS (Westergreen) and CRP (nephelometry). Fifteen JSLE patients had active disease (SLEDAI score &gt;4) and 34 had nephritis. Statistical analysis used Mann-Whitney U test and Spearman9s rank. A p&lt;0.05 was considered significant. <h3>Results</h3> sTyro3, sAxl, sMer and Gas6 ligand were detected in all patients and controls with results similar to that described in literature. JSLE patients presented sTyro3, sAxl, sMer and Gas6 ligand levels similar to healthy controls and patients with active disease and with nephritis had the higher levels, but without statistical significance. TAM receptors and Gas6 ligand levels did not correlated with disease activity parameters. JIA patients had soluble levels similar to healthy controls. (Table) <h3>Conclusions</h3> To our knowledge this is the first study to quantify soluble TAM (Tyro3, Axl, Mer) receptors and Gas6 ligand in JSLE patients. Although most studies with adult onset LES have reported increased concentrations this was not observed in JSLE patients even when we considered patients with active disease and with nephritis. Further studies with exclusively JSLE patients are needed to confirm these results. <h3>References</h3> Zhu H, et al. Lupus 2014;23:624-34. Recarte-Perlz P, et al. Arthritis Res Ther 2013;15:R41. Gheita TA, et al. J Clin Immunol. 2012;32:1279-86. Wu J, et al. Arthritis Res Ther 2011;13:R62. Suh CH, et al. Arthritis Res Ther. 2010;12:R146. <h3>Acknowledgements</h3> We thank FAPESP (grants 2012/22997-4 and 2008/58238-4) for supporting this study. <h3>Disclosure of Interest</h3> None declared
Association Between Level of Fibrosis, Rather Than Antiviral Regimen, and Outcomes of Patients With Chronic Hepatitis B
Authors: Hye Soo Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Ki Jun Song, Jung Won Park, Yeong Jin Kim, Oidov Baatarkhuu, Kwang-Hyub Han, Sang Hoon Ahn
Journal: Clinical Gastroenterology and Hepatology (2016)
Dosing error in protocol book.
Authors: R T Dorr, D Lauper
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.11.2520 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7964972 Dosing error in protocol book. R T DorrxR T DorrSearch for articles by this author , D LauperxD LauperSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.11.2520 PDF "Dosing error in protocol book.." Journal of Clinical Oncology, 12(11), p. 2520© 1994 by American Society of Clinical Oncology
AB1248-HPR Work Ability in Patients with Polymyositis and Dermatomyositis: An Explorative and Descriptive Study
Authors: M. Regardt, E. Welin Henriksson, J. Sandqvist, I.E. Lundberg, M.-L. Schult
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Polymyositis (PM) and dermatomyositis (DM) are characterized by muscle weakness which affects activity and participation. Work and leisure are the activities patients with PM/DM perceive as most limited. Previous studies addressing work in terms of how many are employed and degree of sick-leave. No study has investigated the self-rated work ability or how the work environment affects the ability to work in these patients. <h3>Objectives</h3> This study aimed to investigate the work situation, work ability, work-related risk factors, and influence of the physical and psycho-social work environment in patients with polymyositis (PM) and dermatomyositis (DM). <h3>Methods</h3> Patients with PM/DM were assessed using the Work Ability Index (WAI), and the Work Environment Impact Scale (WEIS). <h3>Results</h3> Forty-eight patients (PM n=25 and DM n=23) participated (women/men: 29/19) with a mean age of 54 years (range 28-67 years, SD.10) and mean disease duration of nine years (SD.9). Forty-four percent worked full-time, 31% part-time and 25% were on full-time sick leave. More than 50% self-rated work ability as “poor” or “less good”. Physically strenuous work components were present “quite to very often” in 23-79% and more in patients on sick leave ≥2 years. For those working, the interfering factors in the work environment concerned task and time demands. Supporting factors concerned meaning of work, interactions with co-workers and others. Self-rated work ability correlated moderately–highly positive with percentage of full-time employment, work-related risk factors and opportunities and constraints in the work environment. <h3>Conclusions</h3> Poor self-rated work ability is common in patients with PM/DM indicating a need to identify interfering risk factors and support patients to enhance work performance. <h3>Disclosure of Interest</h3> None declared
Endoscopic closure of gastrocutaneous leakage with polyglycolic acid sheets
Authors: Yasuaki Nagami, Masatsugu Shiba, Kazunari Tominaga, Sadaaki Yamazoe, Ryosuke Amano, Yasuhiro Fujiwara, Tetsuo Arakawa
Journal: Endoscopy (2015)

Gastrointestinal leakage after surgery is not amenable to several forms of conservative management, and reoperation strategies increase the risk for morbidity and mortality [1]. We report a case of successful endoscopic closure of a gastrocutaneous fistula with polyglycolic acid (PGA) sheets (Neoveil; Gunze Medical Division, Kyoto, Japan) and fibrin glue (Beriplast P Combi-Set; CSL Behring Pharma, Tokyo, Japan).
Questioning Nicotine Replacement Therapy Without Behavioral Support
Authors: Daniel Kotz, Jamie Brown, Robert West
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Studies on the Mechanism of Leucine-Induced Hypoglycemia
Authors: S PENSUWAN, F ZACHAREWICZ, R YERRY, T F FRAWLEY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Reply:
Authors: Kirsty Boyd, Barbara Kimbell, Scott Murray, John Iredale
Journal: Hepatology (2012)

We are delighted to receive a response to our article, "Living and dying well with end-stage liver disease: time for palliative care," highlighting the importance of pain control in people with end-stage liver disease (ESLD) and drug dependency. We agree entirely that trying to achieve optimal pain and symptom control for all our patients, whatever their medical or social history, should be our aim. When we stated that opioids can be problematic in patients with a history of substance abuse (alcohol or drug dependency or both), we sought to highlight that opioid analgesics should be used with additional care, as we outlined in the paragraph that followed. We had insufficient space to address the wider medical and supportive care challenges of providing good care for a complex patient group who often benefit from multidisciplinary management by clinicians with expertise in palliative care, pain management, and drug and alcohol liaison services. We need to avoid fear of opioid use from depriving patients of effective analgesia while also monitoring drug supply and carefully titrating any opioids used. Longer acting opioids are recommended in patients with continuing drug dependency, if at all possible.1 Incomplete cross-tolerance between opioids and opioids given by different routes of administration is compounded by the abnormal pharmacokinetics of advanced liver disease. For example, we have observed a relatively small dose of subcutaneous morphine added to regular methadone to cause significant sedation in our patients with ESLD. It is clear that there is a huge need to develop and research supportive and palliative care in this relatively neglected patient group. Hopefully, improving the care of all patients with ESLD will have a higher profile in the future.
Postoperative gas gangrene.
Authors: J Dankert, J Oldhoff, J S Kuipers
Journal: BMJ (1967)

BaP -Benzo[a]pyreneBDDI -E/Z-2-Benzylidene-5,6-Dimethoxy-3,3-Dimethylindan-1-one bHLH -Basic helix-loop-helix BPDE -7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene -2-methyl-2H-pyrazolo-3-carboxylic acid(2-methyl-4-o-tolylazo-phenyl CH223191
Case 40-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Benjamin Castleman, Ronald A. Malt
Journal: New England Journal of Medicine (1970)

Presentation of Case First admission. A 60-year-old woman was admitted to the hospital because of jaundice.She had experienced intolerance of fatty foods for many years. Four weeks before admission her stools became light, and her urine dark, and jaundice developed. Two weeks later there was the onset of generalized pruritus.On physical examination the patient appeared well but was icteric. Numerous ecchymoses and excoriations were evident. The edge of the liver, which was nontender, was palpated 8 cm below the right costal margin; the gallbladder and spleen were not felt.The temperature was 97.8°F, the pulse 78, and . . .