FRI0417 Vitamin D Deficiency Prevalence in Systemic Lupus Erythematous; Regardless A Cause or a Consequence does it Impact Disease Course, Activity or Severity?
Authors: N. Abaza, R. Elmallah, A. Shaban, S.A. Mobasher, K.F. Alhassanein, A.A. Abdelmageedb, R.H. Elkabarity
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Emerging role of vitamin D in immunology and autoimmune disorders has been a worldwide interest in the last decade. Systemic lupus erythematosus (SLE) patients are particularly at a delicate position predisposing them to suffer from vitamin D deficiency due to the multiple risk factors accompanying the disease. Whether vitamin D deficiency is also involved as a risk factor for developing SLE and affecting its course is a considerable concern. <h3>Objectives</h3> To estimate prevalence of vitamin D deficiency in SLE and its relation to disease activity and severity. <h3>Methods</h3> In our observational cross-sectional study, serum levels of vitamin D from 60 SLE patients and 30 age &amp; sex matched healthy controls (HC) were assessed and estimated for deficiency or insufficiency at 10 and 30ng/ml respectively. Disease activity was evaluated by SLEDAI, irreversible organ damage by SLICC/ACR index and severity by Lupus SDI. Fatigue was measured by visual analogue scale (VAS). <h3>Results</h3> Significantly lower levels of 25(OH)D were found in SLE patients (17.6±6.9 ng/ml) in comparison to controls (79.0±28.7 ng/ml)with statistically high significant difference (t=-11.2, p&lt;0.001).High prevalence of vitamin D insufficiency and deficiency was detected 73.3% &amp; 23.3% respectively. Vitamin D had a highly significant negative correlation with SLEDAI (r =-0.495, p&lt;0.001), see figure 1a, SLICC (r =- 0.431, p&lt;0.05) as well as fatigue (r =- 0.436, p&lt;0.05), see figure 1b. After standardization of all clinical variants, regression analysis study showed that there is significantly inverse correlated between vit D and VAS (standardized regression coefficient β=-0.443, p=0.024) and a highly significant correlation between vit D and SLEDAI score (β=-0.940, p=0.012). <h3>Conclusions</h3> Vitamin D deficiency &amp; insufficiency were found to be prevalent in SLE patients in our study and related to disease activity &amp; fatigue. Routine screening and consequent repletion of vitamin D if needed is recommended in SLE. Restoring adequate vitamin D level in SLE should be more explored as a potential and simple yet valuable measure to be added to their usual management to alleviate their condition. <h3>References</h3> Kamen DL, Cooper GS, Bouali H, Shaftman SR, Hollis BW, Gilkeson GS. Vitamin D deficiency in systemic lupus erythematosus. Autoimmun Rev 2006; 5: 114–117. Ruiz-Irastorza G, Egurbide MV, Olivares N, Martinez-Berriotxoa A, Aguirre C. Vitamin D deficiency in systemic lupus erythematosus: prevalence, predictors and clinical consequences. Rheumatology (Oxford) 2008;47:920–3. Fragoso TS, Dantas AT, Marques CD, Rocha Junior LF, Melo JH, Costa AJ, Duarte AL. 25-Hydroxyivitamin D3 levels in patients with systemic lupus erythematosus and its association with clinical parameters and laboratory tests. Rev Bras Reumatol. 2012 Jan-Feb;52(1):60-5 <h3>Disclosure of Interest</h3> None declared