tbuckley/cabot-search huggingface dataset:
Preliminary results of the validation of a patient (pt) self-administered questionnaire (Oral Mucositis Weekly Questionnaire-Head and Neck [OMWQ-HN]) to assess the impact of OM on pain and functioning in head and neck cancer (HNC)
Authors: J. B. Epstein, J. L. Beaumont, C. K. Gwede, A. Trotti, M. McDowell, B. Murphy, A. Garden, R. Meredith, L. Quynh-Thu, D. Brizel
Journal: Journal of Clinical Oncology (2006)

5548 Background: Pt self-reported questionnaires measuring acute and specific effects of OM are needed to assess effects of interventions and guide patient care. We evaluated the feasibility, validity, and reliability of the OMWQ-HN on OM and its impact on pts’ abilities to perform alimentary and other routine functions. Methods: Validity and reliability of the OMWQ-HN was assessed in 75 pts from a prospective multicenter study receiving radiotherapy ± chemotherapy (RTCT). Assessments included test-retest reliability, internal consistency reliability, and cross-sectional validity. The OMWQ-HN’s sensitivity to detect change was demonstrated by using the changes in the Performance Status Scale for HNC (PSS-HN) and the Functional Assessment of Cancer Therapy (FACT-HN) to form 3 independent groups (better, no change, worse) for comparison. Effect sizes (ES) were calculated for group comparisons to measure the clinical significance of differences. Results: Compliance rates were &gt;90% throughout the study. The OMWQ-HN demonstrated good test-retest reliability (r = 0.89). Cronbach’s alpha was &gt;0.85 and mouth, throat, and pain-related items correlated highly with each other (r&gt;0.7). Cross-sectional analyses to assess validity showed that OMWQ-HN scores were different across levels of pain, with those in the worst pain category reporting the most severe OMWQ-HN scores (ES &gt;0.5 for all comparisons). The OMWQ-HN was sensitive to change in FACT-HN and PSS-HN (p &lt; 0.001 and p = 0.013, respectively). Patients reported increases in mouth and throat soreness (MTS) that corresponded with a steady decline in oral function. Conclusions: These results indicate the OMWQ-HN is a feasible, valid, and reliable instrument for assessing the impact of mucositis on patients receiving RTCT in the HNC patient care setting. [Table: see text]
Abstract 5880: Serum Resistin Concentrations and Risk of New Onset Heart Failure in the Elderly
Authors: Vasiliki V Georgiopoulou, Andreas P Kalogeropoulos, Nathalie de Rekeneire, Nicolas Rodondi, Andrew L Smith, Udo Hoffmann, Alka Kanaya, Anne B Newman, Stephen B Kritchevsky, Ramachandran S Vasan, Peter W Wilson, Tamara B Harris, Javed Butler
Journal: Circulation (2008)

Resistin, a novel adipocytokine, is associated with inflammation and insulin resistance; both mechanisms are known to increase risk for heart failure (HF). We studied 2904 older persons without HF (age 73.3±2.8 years, 47.9% men, 58.6% whites) enrolled in the Health ABC study who underwent serum resistin measurements at baseline. Participants were divided into groups based on tertiles of resistin concentrations and rates of incident HF (defined as hospitalization for new onset HF) were compared by Cox proportional hazards models. After 7.1 year median follow-up 252 participants (8.7%) developed HF. Increasing resistin concentrations were significantly associated with increasing incident HF rates (Figure 1 ). After adjusting for baseline differences (including body mass index) and predictors of incident HF (age, coronary disease, smoking, blood pressure, heart rate, serum glucose, creatinine, and albumin concentrations, and left ventricular hypertrophy), serum resistin concentrations were independently associated with incident HF [highest vs. lowest tertile hazard ratio (HR) 1.96, 95% confidence interval (CI) 1.35–2.82). Further adjustment for markers of inflammation (Creactive protein, interleukin-6, and tumor necrosis factor α) and of insulin resistance (fasting insulin level and hemoglobin A1c) only moderately attenuated this association which remained significant (HR 1.67, 95% CI 1.13–2.60). These findings were consistent in both sexes and among whites and blacks. High serum resistin concentrations are independently associated with increasedrisk for HF. Further studies are needed to confirm these findings.
P1067 : Associations between antidiabetic and statin therapy and liver histology in patients with type 2 diabetes and non-alcoholic fatty liver disease
Authors: F. Nascimbeni, J. Aron-Wisniewsky, R. Pais, J. Tordjman, F. Charlotte, P. Bedossa, T. Poynard, K. Clement, V. Ratziu
Journal: Journal of Hepatology (2015)
Perioperative and Long-term Outcomes After Carotid Endarterectomy in Hemodialysis Patients
Authors: Michol Cooper, Isibor J. Arhuidese, Tammam Obeid, Caitlin W. Hicks, Joseph Canner, Mahmoud B. Malas
Journal: JAMA Surgery (2016)

Early landmark trials excluding dialysis patients showed carotid endarterectomy (CEA) decreased stroke risk compared with medical management. Dialysis dependence has been associated with poor outcomes after CEA in small studies, but, to our knowledge, there are no large studies evaluating outcomes of CEA in this patient group. To delineate perioperative and long-term outcomes after CEA in dialysis-dependent patients in a large national database. A retrospective review of all patients who underwent CEA in the US Renal Disease System-Medicare-matched database between January 1, 2006, and December 31, 2011, was performed in June 2015. The median follow-up time was 2.5 years. Logistic and Cox regression analyses were used to evaluate perioperative and long-term outcomes. The primary outcomes of interest were perioperative stroke, myocardial infarction and mortality, and long-term stroke and mortality. A total of 5142 patients were studied; 83% of whom were asymptomatic. The mean (SD) age was 68.9 (9.6) years for asymptomatic patients and 70.0 (9.1) years for symptomatic patients. The 30-day stroke rate, myocardial infarction, and mortality for the asymptomatic and symptomatic groups were 2.7% vs 5.2% (P = .001), 4.6% vs 5.0% (P = .69), and 2.6% vs 2.9% (P = .61), respectively. Predictors of perioperative stroke were symptomatic status (odds ratio [OR], 2.01; 95% CI, 1.18-3.42; P = .01), black race (OR, 2.30; 95% CI, 1.24-4.25; P = .008), and Hispanic ethnicity (OR, 2.28; 95% CI, 1.17-4.42; P = .02). Freedom from stroke and overall survival were lower in symptomatic compared with asymptomatic patients at 1, 2, 3, 4, and 5 years (in asymptomatic vs symptomatic patients, freedom from stroke rates were 92% vs 87% at 1 year, 88% vs 83% at 2 years, 84% vs 78% at 3 years, 80% vs 73% at 4 years, and 79% vs 69% at 5 years, respectively, and overall survival rates were 78% vs 73% at 1 year, 60% vs 57% at 2 years, 46% vs 42% at 3 years, 37% vs 32% at 4 years, and 33% vs 29% at 5 years; P < .05). Predictors of long-term stroke were preoperative symptoms (hazard ratio, 1.67; 95% CI, 1.24-2.24; P < .001), female sex (hazard ratio, 1.34; 95% CI, 1.03-1.73; P = .04), and inability to ambulate (hazard ratio, 1.81; 95% CI, 1.25-2.62; P = .002). Predictors of long-term mortality were increasing age (OR, 1.02; 95% CI, 1.01-1.03; P < .01), active smoking (OR, 1.22; 95% CI, 1.00-1.48; P = .045), history of congestive heart failure (OR, 1.25; 95% CI, 1.12-1.39; P < .001), and chronic obstructive pulmonary disease (OR, 1.26; 95% CI, 1.09-1.45; P = .002). To our knowledge, this is the largest study to date of dialysis patients who have undergone CEA. We have shown that the risks of CEA in asymptomatic patients is high and may outweigh the benefits. The risk of CEA in symptomatic patients is also high, and it should only be offered to a small carefully selected cohort of symptomatic patients.
Stem Cell Bioprinting: Functional 3D Neural Mini‐Tissues from Printed Gel‐Based Bioink and Human Neural Stem Cells (Adv. Healthcare Mater. 12/2016)
Authors: Qi Gu, Eva Tomaskovic‐Crook, Rodrigo Lozano, Yu Chen, Robert M. Kapsa, Qi Zhou, Gordon G. Wallace, Jeremy M. Crook
Journal: Advanced Healthcare Materials (2016)

On page 1429 G. G. Wallace, J. M. Crook, and co-workers report the first example of fabricating neural tissue by 3D bioprinting human neural stem cells. A novel polysaccharide based bioink preserves stem cell viability and function within the printed construct, enabling self-renewal and differentiation to neurons and supporting neuroglia. Neurons are predominantly GABAergic, establish networks, are spontaneously active, and show a bicuculline induced increased calcium response.
Holiday Reflections
Authors: John Lister
Journal: New England Journal of Medicine (1974)

NOT so long ago, I was pleased to meet an English medical student who subscribes to the Journal. I was glad to hear him speak well of it, and flattered to learn that he reads the London Post to find out what is going on in Britain. I was somewhat dismayed, however, when he asked me, "What is the source of your information?" I replied that I just keep my eyes and my ears open, and always hope that something relevant will turn up each month.This was perhaps an oversimplification, because I suppose I do have something of . . .
Incidence of and Risk Factors for Chronic Opioid Use Among Opioid-Naive Patients in the Postoperative Period
Authors: Eric C. Sun, Beth D. Darnall, Laurence C. Baker, Sean Mackey
Journal: JAMA Internal Medicine (2016)

Chronic opioid use imposes a substantial burden in terms of morbidity and economic costs. Whether opioid-naive patients undergoing surgery are at increased risk for chronic opioid use is unknown, as are the potential risk factors for chronic opioid use following surgery.
Re: Familial multiple myeloma: A family study and review of the literature (multiple letters)
Authors: Hagay Sobol, Norbert Vey, Richard Sauvan, Nicole Philip, Tetsuro Noguchi, François Eisinger, Kari Hemminki, Henry T. Lynch, Warren G. Sanger, Samuel Pirruccello, Brigid Quinn-Laquer, Dennis D. Weisenburger
Journal: JNCI Journal of the National Cancer Institute (2002)
Ischemic Limb Gangrene with Pulses
Authors: Malvinder S Parmar
Journal: New England Journal of Medicine (2015)

To the Editor: Warkentin (Aug. 13 issue)1 highlights the misconception that all cases of ischemic limb gangrene are associated with the loss of an arterial pulse and presents the two syndromes associated with disseminated intravascular coagulation in which ischemic limb gangrene can occur with a pulse. However, in so doing, he may have created another misconception — the idea that ischemic limb gangrene with pulses is related to syndromes associated with disseminated intravascular coagulation. It is important to recognize that ischemic limb gangrene with pulses can occur without associated disseminated intravascular coagulation, as it does in calcific uremic arteriolopathy (calciphylaxis)2 and cholesterol embolization (atheroembolism).3 Cholesterol embolization should not be confused with arterial thrombosis.4 It is important to consider these possibilities in the differential diagnosis of ischemic limb gangrene with pulses. In a simplified approach to patients with limb gangrene, the clinician should first determine whether a pulse is present; if it is, the differential diagnosis should be based on whether there is an association with disseminated intravascular coagulation (Fig. 1).
Case 47-1964
Authors: Lot B. Page, Friedrich J. Gloor
Journal: New England Journal of Medicine (1964)

Presentation of CaseA three-month-old male infant was admitted to the hospital because of a convulsion.The child was delivered at term by cesarean section because a previous cesarean section had been necessitated by a placenta previa. He frequently regurgitated feedings, despite several changes in the formula, and at the age of two months the curve of weight gain began to diminish markedly. Three weeks before admission chicken pox developed. Three days before entry he suddenly became apneic after being startled by a noise. The attack subsided promptly. but two days later he was somnolent and refused feedings. A physician . . .
Case 22-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, George R. Leopold, George F. Murphy
Journal: New England Journal of Medicine (1980)

Presentation of CaseA 59-year-old man was admitted to the hospital because of weakness and melena.He was well until four years earlier, when abdominal pain developed. He was seen at another hospital, where an abdominal soft-tissue mass was found. A diagnosis of probable cholecystitis was made. Two years before admission repeated examination at the other hospital again revealed an abdominal mass. A barium-enema examination demonstrated abundant diverticula but was otherwise negative. Six months before entry an upper gastrointestinal series showed that the gastric antrum was displaced superiorly and the duodenal loop posteriorly by a soft-tissue mass; no intrinsic abnormality . . .
PD4-2-8: Advanced age is associated with lack of administration of adjuvant chemotherapy for completely resected stage IB-III non-small cell lung cancer (NSCLC)
Authors: Gregory J. Riely, V.E. Seshan, C.G. Azzoli, Mark G. Kris, Valerie W. Rusch, Bernard K. Park
Journal: Journal of Thoracic Oncology (2007)
Preclinical Assessment of CD171-Directed CAR T-cell Adoptive Therapy for Childhood Neuroblastoma: CE7 Epitope Target Safety and Product Manufacturing Feasibility
Authors: Annette Künkele, Agne Taraseviciute, Laura S. Finn, Adam J. Johnson, Carolina Berger, Olivia Finney, Cindy A. Chang, Lisa S. Rolczynski, Christopher Brown, Stephanie Mgebroff, Michael Berger, Julie R. Park, Michael C. Jensen
Journal: Clinical Cancer Research (2016)

Abstract Purpose: The identification and vetting of cell surface tumor-restricted epitopes for chimeric antigen receptor (CAR)–redirected T-cell immunotherapy is the subject of intensive investigation. We have focused on CD171 (L1-CAM), an abundant cell surface molecule on neuroblastomas and, specifically, on the glycosylation-dependent tumor-specific epitope recognized by the CE7 monoclonal antibody. Experimental Design: CD171 expression was assessed by IHC using CE7 mAb in tumor microarrays of primary, metastatic, and recurrent neuroblastoma, as well as human and rhesus macaque tissue arrays. The safety of targeting the CE7 epitope of CD171 with CE7-CAR T cells was evaluated in a preclinical rhesus macaque trial on the basis of CD171 homology and CE7 cross reactivity. The feasibility of generating bioactive CAR T cells from heavily pretreated pediatric patients with recurrent/refractory disease was assessed. Results: CD171 is uniformly and abundantly expressed by neuroblastoma tumor specimens obtained at diagnoses and relapse independent of patient clinical risk group. CD171 expression in normal tissues is similar in humans and rhesus macaques. Infusion of up to 1 × 108/kg CE7-CAR+ CTLs in rhesus macaques revealed no signs of specific on-target off-tumor toxicity. Manufacturing of lentivirally transduced CD4+ and CD8+ CE7-CAR T-cell products under GMP was successful in 4 out of 5 consecutively enrolled neuroblastoma patients in a phase I study. All four CE7-CAR T-cell products demonstrated in vitro and in vivo antitumor activity. Conclusions: Our preclinical assessment of the CE7 epitope on CD171 supports its utility and safety as a CAR T-cell target for neuroblastoma immunotherapy. Clin Cancer Res; 23(2); 466–77. ©2016 AACR.
Fucosylation Inhibitor, 2-Fluorofucose, Inhibits NF-κB Activation and Vaso-Occlusion In Transgenic Sickle Mice
Authors: John D Belcher, Chunsheng Chen, Julia Nguyen, Nicole M. Okeley, Peter D. Senter, Dennis R. Benjamin, Gregory M Vercellotti
Journal: Blood (2013)
Case 2-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, James R. Lehrich, Edward P. Richardson
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 30-year-old man was admitted to the hospital because of confusion and headaches.He was well until one month previously, when intermittent headaches developed. Two weeks before admission he began to have nausea, vomiting, and photophobia and complained of "sinusitis." During the next week the symptoms worsened. One week before entry a brief episode of confusion occurred and subsided spontaneously. His physician prescribed a mixture of phenobarbital and codeine, and the nausea and vomiting ceased. On the day before admission the patient appeared well and returned to his work as an electrical engineer but was brought home . . .
Necrotizing Colitis of the Newborn: Common Cause of Perforation of Colon
Authors: J A WALDHAUSEN, T HERENDEEN, H KING
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Cardiovascular safety of methylphenidate should also be considered in adults
Authors: François Montastruc, Guillaume Montastruc, Jean-Louis Montastruc, Alexis Revet
Journal: BMJ (2016)

Shin and colleagues showed an increased risk of arrhythmia from methylphenidate in children and young people with attention-deficit/hyperactivity disorder (ADHD).1 We were recently notified in our clinical unit of a spontaneous adverse drug reaction of ventricular extrasystoles in a 45 year old patient who had been taking methylphenidate alone (36 mg each working day) for two months. A few days after starting treatment he …
P-027 Cancer stem cells marker CD44 and Notch activation predict unfavorable prognosis in metastatic colon cancer patients treated with anti VEGF-therapy
Authors: F.V. Negri, C. Bozzetti, C. Azzoni, L. Bottarelli, A. Squadrilli, G. Pedrazzi, C. Lagrasta, I. Tamagnini, A. Bisagni, R. Porzio, G. Tomasello, F. Leonardi, C. Pinto, A. Ardizzoni, R. Sala, F. Quaini
Journal: Annals of Oncology (2016)
Development and validation of multivariable predictive model for thromboembolic events in lymphoma patients
Authors: Darko Antic, Natasa Milic, Srdjan Nikolovski, Milena Todorovic, Jelena Bila, Predrag Djurdjevic, Bosko Andjelic, Vladislava Djurasinovic, Aleksandra Sretenovic, Vojin Vukovic, Jelena Jelicic, Suzanne Hayman, Biljana Mihaljevic
Journal: American Journal of Hematology (2016)

Lymphoma patients are at increased risk of thromboembolic events but thromboprophylaxis in these patients is largely underused. We sought to develop and validate a simple model, based on individual clinical and laboratory patient characteristics that would designate lymphoma patients at risk for thromboembolic event. The study population included 1,820 lymphoma patients who were treated in the Lymphoma Departments at the Clinics of Hematology, Clinical Center of Serbia and Clinical Center Kragujevac. The model was developed using data from a derivation cohort (n = 1,236), and further assessed in the validation cohort (n = 584). Sixty-five patients (5.3%) in the derivation cohort and 34 (5.8%) patients in the validation cohort developed thromboembolic events. The variables independently associated with risk for thromboembolism were: previous venous and/or arterial events, mediastinal involvement, BMI>30 kg/m(2) , reduced mobility, extranodal localization, development of neutropenia and hemoglobin level < 100g/L. Based on the risk model score, the population was divided into the following risk categories: low (score 0-1), intermediate (score 2-3), and high (score >3). For patients classified at risk (intermediate and high-risk scores), the model produced negative predictive value of 98.5%, positive predictive value of 25.1%, sensitivity of 75.4%, and specificity of 87.5%. A high-risk score had positive predictive value of 65.2%. The diagnostic performance measures retained similar values in the validation cohort. Developed prognostic Thrombosis Lymphoma - ThroLy score is more specific for lymphoma patients than any other available score targeting thrombosis in cancer patients. Am. J. Hematol. 91:1014-1019, 2016. © 2016 Wiley Periodicals, Inc.
New Immunophenotypic Profile of Waldenstrom’s Macroglobulinemia: Interest of CD80 and CD86 Staining
Authors: Andrea Toma, Magali Le Garff-Tavernier, Martine Brissard, Patrick Bonnemye, Lucille Musset, Nabih Azar, Veronique Leblond, Helene Merle-Beral
Journal: Blood (2008)
An autochthonous case of cystic echinococcosis in Finland, 2015
Authors: Sari Hämäläinen, Anu Kantele, Miika Arvonen, Tapio Hakala, Jari Karhukorpi, Jukka Heikkinen, Ensio Berg, Kari Vanamo, Erja Tyrväinen, Tarja Heiskanen-Kosma, Antti Oksanen, Antti Lavikainen
Journal: Eurosurveillance (2015)

We report a case of pulmonary cystic echinococcosis in a child from eastern Finland with no history of travelling abroad. The cyst was surgically removed and the organism molecularly identified as Echinococcus canadensis genotype G10. This parasite is maintained in eastern Finland in a sylvatic life cycle involving wolves and moose; in the present case, the infection was presumably transmitted by hunting dogs.
DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes
Authors: Roser Vento-Tormo, Damiana Álvarez-Errico, Antonio Garcia-Gomez, José Hernández-Rodríguez, Segundo Buján, Maria Basagaña, Maria Méndez, Jordi Yagüe, Manel Juan, Juan I. Aróstegui, Esteban Ballestar
Journal: Journal of Allergy and Clinical Immunology (2016)