tbuckley/cabot-search huggingface dataset:
PWE-185 Is the mortality from upper gastrointestinal bleeding in england increased at the weeknd?
Authors: J Rees, N Trudgill, F Evison
Journal: Gut (2015)

<h3>Introduction</h3> Several medical conditions are associated with an increased mortality at the weekend. A UK prospective study of patients with upper gastrointestinal bleeding (UGIB) in 2011 showed no mortality difference between weekday and weekend admissions despite patients admitted at the weekend being more likely to be shocked, require blood and wait longer for endoscopy. A Welsh record linkage study examining 24, 421 admissions found that mortality was 13% higher for weekend and 41% higher for bank holiday admissions. <h3>Method</h3> Using Hospital Episode Statistics (HES), we identified all patients admitted to hospital with UGIB between April 2001 and March 2014. Patients who underwent an in-patient endoscopy were analysed using multivariate regression analysis to explore the relationship between day of admission, age, ethnicity, comorbidity, diagnosis and length of time to endoscopy and mortality. <h3>Results</h3> 885,572 UGIB admissions were identified with 421,726 of these (59% male, 41% female) resulting in an inpatient endoscopy. Patients admitted on a bank holiday had a higher risk of death within 30 days (OR 1.08, 95% CI 1.01–1.16, p 0.0231), as did patients admitted on a Sunday (1.10, 95% CI 1.07–1.13, p &lt; 0.001). Females had a lower mortality when compared to male patients (0.95, 95% CI 0.93–0.97, p &lt; 0.001). Those of a white/British ethnicity had a higher mortality when compared to those of an Asian (0.79, 95% CI 0.74–0.85, p &lt; 0.001), Black (0.72, 95% CI 0.65–0.79, p &lt; 0.001) or Chinese background (0.66, 95% CI 0.52–0.85, p = 0.001). Mortality increased with age with patients over 85 having the poorest prognosis. Increasing comorbidity was associated with increased risk of death with a Charlson score of 1–4 giving an OR of 1.18 (95% CI 1.13–1.22, p &lt; 0.001) and a Charlson score of 5+ giving an OR of 2.80 (95% CI 2.73–2.86, p &lt; 0.001). There was an increased 30-day mortality with varices (2.80, 95% CI 2.66–2.95, p &lt; 0.001) and peptic ulcers (1.22, 95% CI 1.19–1.26, p &lt; 0.001). Patients who underwent an endoscopy on the day of admission had an increased 30-day mortality (OR 1.42, 95% CI 1.38–1.46, p &lt; 0.001) but the highest risk of death was in patients who waited 4 or more days for their endoscopy (OR 1.80, 95% CI 1.75–1.85, p &lt; 0.001). <h3>Conclusion</h3> There is a higher risk of death within 30 days if admitted on a Sunday or a bank holiday with UGIB. Predictably, older patients, males and those with more comorbidity had a poorer prognosis. Patients who undergo endoscopy on the day of admission have a higher mortality, probably because they are more unstable on admission. <h3>Disclosure of interest</h3> None Declared.
SAT0379 Is Fatigue Immune-Mediated in Primary SjÖgren's Syndrome? Data from the Prospective Assess Cohort
Authors: J.E. Gottenberg, R. Seror, J. Benessiano, V. Devauchelle-Pensec, P. Dieude, J.J. Dubost, A.L. Fauchais, V. Goeb, E. Hachulla, P.Y. Hatron, C. Larroche, V. Le Guern, C. Micelli-Richard, J. Morel, A. Perdriger, X. Puéchal, S. Rist, A. Saraux, D. Sene, J. Sibilia, O. Vittecoq, G. Nocturne, P. Ravaud, X. Mariette
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Little is known about the pathogenesis of fatigue, a hallmark of primary Sjögren9s syndrome. The respective contribution of depression, disease activity, or auto-immunity itself has never been studied ever since international disease activity scores were established. We therefore investigated the association between fatigue and other characteristics of the disease in a large multi-center prospective cohort. <h3>Methods</h3> ASSESS is a multi-center prospective cohort which included 395 patients. At baseline and every year of the follow-up, systemic disease activity and patient-related outcome are evaluated by the ESSDAI and ESSPRI (the average of patient9s visual analogic scales (VAS) for fatigue, pain and dryness), respectively, and patients fill questionnaires including the Hospital Anxiety and Depression (HAD) scale. Serum markers of B-cell activation, BAFF, interferon (IFN)-inducible chemokines, and IL-21 were assessed. <h3>Results</h3> Median (25th-75th) fatigue VAS was 6 (4-8). Fatigue VAS was correlated with dryness VAS (r=0.46, p&lt;0.0001) and pain VAS (r=0.54, p&lt;0.0001). Fatigue VAS was not correlated with age or disease duration, the ESSDAI, unstimulated salivary flow or Schirmer9s test. Fatigue VAS was significantly higher in patients with depression (defined by a HAD subscale for depression (HAD-D) ≥8 (median fatigue VAS of 7 (6-9) in patients with depression and of 6 (4-8) in patients without depression, p&lt;0.0001). In patients without depression, fatigue VAS remained not associated with anti-SSA, the ESSDAI, unstimulated salivary flow and Schirmer9s test. Among patients without depression, a high fatigue VAS (≥5, the median of fatigue VAS in these patients) was not associated with a higher level of serum IFN-inducible chemokines (CCL2, CXCL10, CCL19), B-cell activating cytokines such as BAFF or IL-21, markers of B-cell activation (total Ig levels, free light chains of immunoglobulins, rheumatoid factor levels). <h3>Conclusions</h3> These results confirm the diversity of factors associated with fatigue in primary Sjögren9s syndrome, including depression and the two other main symptoms, dryness and pain. Even when focusing on patients without depression, no association was observed between fatigue and systemic disease activity, autoantibody profile, serum surrogate markers of the IFN signature and of B-cell activation. Further work is necessary to determine the existence of potential other immunological drivers. <h3>Disclosure of Interest</h3> None declared
Ruxolitinib in Combination with Nilotinib and Prednisolone, a New Synergistic Approach to Treat Myelofibrosis
Authors: Alicia Arenas, Pilar Hernandez-Campo, Julian Gorrochategui, Daniel Primo, Rosa M. Ayala, Blanca Ferrer-Lores, Joan Ballesteros, Joaquin Martinez-Lopez
Journal: Blood (2014)
Surgery of Coronary Artery Disease
Journal: Thorax (1987)

diagnosed by this combination of ZN (19 positive cases) and AR (18 positive cases) staining techniques, eight of which were pulmonary tuberculosis (two cases of miliary tuberculosis).Only four cases were not detected by these tech- niques, probably as a result of sampling error (no granu- lomatous tissue), the diagnosis being later established by bacteriological examination.There was only one sputum positive case.Our data demonstrated the superiority of the AR method over the ZN method, but they were also complementary and used in combination allow faster screening for the organism.The sensitivity and efficiency were substantially enhanced when the two stains were combined and were done on serial sections.2
SAT0494 Long-Term Retention and Predictors of Anti-Tnf Treatment Response in Juvenile Idiopathic Arthritis: Data from Reuma.PT, a Nation-Wide Register
Authors: A.F. Mourão, M.J. Santos, J.A. Melo Gomes, F. Martins, S. Mendonça, F.O. Ramos, S. Fernandes, M. Salgado, M. Guedes, S. Carvalho, J.A. Costa, I. Brito, C. Duarte, C. Furtado, G. Sequeira, A. Lopes, A. Rodrigues, J.C. Branco, J.E. Fonseca, H. Canhão
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To assess the effectiveness and safety of biological therapy as well as predictors of response after 1 year of therapy, the retention rate in biological treatment and predictors of drug discontinuation in JIA patients registered in the Portuguese register of rheumatic diseases, Reuma.pt. <h3>Methods</h3> We collected prospectively patient and disease characteristics from patients with JIA who started biological disease modifying antirheumatic drugs. Adverse events were collected during the overall follow-up period. The predictors of response at 1 year were assessed and drug retention rates were calculated at 4 years of treatment for the first biologic agent using the Kaplan-Meier method. <h3>Results</h3> Of the 812 JIA patients registered in Reuma.pt, 227 received biological therapy. The mean age at disease onset was 7.5±4.9 years and the mean age at the beginning of biological therapy was 16.2±9.4 years. The most common JIA category on biologics was polyarticular rheumatoid factor (RF) negative (23.3%). Most patients (90.3%) were treated with an anti-TNF as first biologic (etanercept, 69.2%). Disease activity decreased significantly at 6 months and 1 year of treatment. Fourteen patients discontinued biological therapies during the follow-up period due to adverse events. Baseline JADAS10 was the strongest predictor of treatment response at 1 year of biological therapy, with a 0.73 decrease for each unit increase at baseline (95% CI 0.45-1.10, p&lt;0.001). Retention rates for the first biological agent were: 92.9% at 1 year, 85.5% at 2 years, 78.4% at 3 years and 68.1% at 4 years of treatment. Among all JIA subtypes, only concomitant therapy with corticosteroids was found to be univariately associated with withdrawal of biological treatment (p=0.016). <h3>Conclusions</h3> Data from Reuma.pt confirm that biological therapies are effective and safe in patients with JIA. Additionally, baseline disease activity was the strongest predictor of treatment response and the retention rates for the first biological agent are high throughout 4 years. <h3>Disclosure of Interest</h3> None declared
A second look at second-look laparotomy.
Authors: R C Young
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.9.1311 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3625251 A second look at second-look laparotomy. R C YoungxR C YoungSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.9.1311 First Page PDF © 1987 by American Society of Clinical Oncology
Failure of nonlinear models of drinking history variables to predict neuropsychological performance in alcoholics
Authors: K M Adams, I Grant
Journal: American Journal of Psychiatry (1984)

To test whether the relationship between drinking parameters and cognitive functioning can be visualized as a curvilinear surface (rather than as a line, which more traditional regression equations presuppose), the authors tested 84 recently detoxified and 72 longer-term abstinent alcoholic men with the Halstead-Reitan battery. Quadratic statistical models did not predict test performance in the first group; a few predictions were found in the second. When the multiple correlation was adjusted for number of cases and variables, the "nonlinear" results were statistically no more significant than those of simpler linear models. It is concluded that drinking history does not readily explain cognitive findings among sober alcoholics and that polynomial models can produce inflated correlation coefficients.
Plethora of websites rating healthcare is unhelpful to public, says think tank
Authors: Nigel Hawkes
Journal: BMJ (2015)

Trying to measure how well healthcare is provided in a local area cannot be reduced to a single indicator, the UK health think tank the King’s Fund has concluded in a new report.1 But neither does the current plethora of different scorecards and websites serve the purpose of telling the public whether they are getting a decent service, it says. 

A much simpler system is needed to meet the aim of the health secretary for England of “intelligent transparency,” in which improvement is driven by everybody’s ability to see how well or badly everybody else is doing, the report recommends.

Chris Ham, the chief executive of the King’s Fund, said that he strongly supported intelligent transparency, but making it work meant careful attention to selecting and presenting performance indicators. “Done well, performance assessment can help strengthen accountability to patients and the public, as well as …
Clinician-computer interaction: automated review of psychotropic drugs
Authors: T J Craig, R M Mehta
Journal: American Journal of Psychiatry (1984)

Five years after its introduction at a state mental hospital, an automated drug exception review system continues to show a long-term impact on the prescribing practices of hospital physicians. Although the overall rate of exceptions has remained low, approximately 25% of all new exceptions pointed out by the computer result in a change in the order by the physician. The fact that 60% of new exceptions are justified suggests that some forms of polypharmacy may be appropriate. The integration of the exception-reporting system into the clinical review process has avoided the danger of the computer's being seen as an adversary to the clinician or as exerting undue control over psychopharmacologic prescription practices.
Irradiation of the Normal Human Hypophysis in Malignancy : Report of Three Cases Receiving 8,100–10,000 R Tissue Dose to the Pituitary Gland&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Keith H. Kelly, Eggert T. Feldsted, Reynold F. Brown, Paul Ortega, Howard R. Bierman, Bertram V. A. Low-Beer, Michael B. Shimkin
Journal: JNCI Journal of the National Cancer Institute (1951)

Irradiation of the Normal Human Hypophysis in Malignancy : Report of Three Cases Receiving 8,100–10,000 R Tissue Dose to the Pituitary Gland Get access Keith H. Kelly, Keith H. Kelly Search for other works by this author on: Oxford Academic PubMed Google Scholar Eggert T. Feldsted, Eggert T. Feldsted Search for other works by this author on: Oxford Academic PubMed Google Scholar Reynold F. Brown, Reynold F. Brown Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Ortega, Paul Ortega Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard R. Bierman, Howard R. Bierman Search for other works by this author on: Oxford Academic PubMed Google Scholar Bertram V. A. Low-Beer, Bertram V. A. Low-Beer Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael B. Shimkin Michael B. Shimkin Laboratory of Experimental Oncology, National Institutes of Health, U. S. Public Health Service, and the Divisions of Medicine, Radiology, and Pathology, University of California School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 5, April 1951, Pages 967–983, https://doi.org/10.1093/jnci/11.5.967 Published: 01 April 1951 Article history Received: 27 December 1950 Published: 01 April 1951
Factitious posttraumatic stress disorder
Authors: L Sparr, L D Pankratz
Journal: American Journal of Psychiatry (1983)

A growing number of young men have reported an array of symptoms that suggest a diagnosis of posttraumatic stress disorder. Five such men, all claiming to be Viet Nam veterans, were treated at a VA medical center; three said they were former prisoners of war. In fact, none had been prisoners of war, four had never been in Viet Nam, and two had never even been in the military. Instead, all five suffered factitious disorders. The authors describe the five patients and discuss differential diagnoses; the value of verifying military histories is stressed.
Critical components of neuromuscular training to reduce ACL injury risk in female athletes: meta-regression analysis
Authors: Dai Sugimoto, Gregory D Myer, Kim D Barber Foss, Michael J Pepin, Lyle J Micheli, Timothy E Hewett
Journal: British Journal of Sports Medicine (2016)

Objective The aim of this study was to determine key components in neuromuscular training that optimise ACL injury reduction in female athletes using meta-regression analyses. Design Systematic review and meta-regression. Data sources The literature search was performed in PubMed and EBSCO. Eligibility criteria Inclusion criteria for the current analysis were: (1) documented the number of ACL injuries, (2) employed a neuromuscular training intervention that aimed to reduce ACL injuries, (3) had a comparison group, (4) used a prospective control study design and (5) recruited female athletes as participants. Two independent reviewers extracted studies which met the inclusion criteria. Methodological quality of included study and strength of recommendation were evaluated. Number of ACL injuries and participants in control and intervention groups, age of participants, dosage of neuromuscular training, exercise variations within neuromuscular training and status of verbal feedback were extracted. Results The meta-regression analyses identified age of participants, dosage of neuromuscular training, exercise variations within neuromuscular training and utilisation of verbal feedback as significant predictors of ACL injury reduction (p=0.01 in fixed-effects model, p=0.03 in random-effects model). Inclusion of 1 of the 4 components in neuromuscular training could reduce ACL injury risk by 17.2–17.7% in female athletes. No significant heterogeneity and publication bias effects were detected. Strength of recommendation was rated as A (recommendation based on consistent and good-quality patient-oriented study evidence). Conclusions Age of participants, dosage of neuromuscular training, exercise variations within neuromuscular training and utilisation of verbal feedback are predictors that influence the optimisation of prophylactic effects of neuromuscular training and the resultant ACL injury reduction in female athletes.
Measures taken to reduce the risk of West Nile virus transmission by transplantation in Italy
Authors: A Nanni Costa, P Grossi, E Porta, S Venettoni, D Fehily
Journal: Eurosurveillance (2008)

For the first time in Italy, two patients with meningoencephalitis were diagnosed with West Nile virus (WNV) infection in September 2008 [1]. The patients live in the Bologna and Ferrara provinces of Emilia Romagna where WNV infections had previously been noted in horses, crows and magpies [2]. The Italian National Transplant Centre (CNT), which is responsible for the procurement, processing and distribution of organs and tissues in Italy, has now reviewed the risks of transmission of WNV by organ, tissue and cell transplantation and, taking into account the advice and recommendations of the relevant authorities in other countries, issued guidance to the transplant community.
Syngeneic adoptive transfer of anti-human immunodeficiency virus (HIV- 1)-primed lymphocytes from a vaccinated HIV-seronegative individual to his HIV-1-infected identical twin
Authors: F Bex, P Hermans, S Sprecher, A Achour, R Badjou, C Desgranges, J Cogniaux, P Franchioli, C Vanhulle, A Lachgar
Journal: Blood (1994)
DCIS neoadjuvant therapy: Targeting the autophagy pathway in malignant precursor cells.
Authors: V. A. Espina, R. I. Gallagher, B. D. Mariani, S. Banks, J. Wiedemann, E. Petricoin, L. Pastore, J. Johal, L. A. Liotta, K. H. Edmiston
Journal: Journal of Clinical Oncology (2010)

TPS341 Background: We found that fresh human breast ductal carcinoma in situ (DCIS) lesions contain pre-existing carcinoma precursor cells which require autophagy (auto-self, phagy-eating) for survival. Autophagy promotes survival of DCIS cells within the hypoxic duct microenvironment. Based on this finding, we are testing the safety and effectiveness of chloroquine phosphate (CQ), alone or in combination with tamoxifen, administered for a 3 month period to patients with any grade DCIS. This unique DCIS neoadjuvant therapy study design provides immediate molecular and biologic feedback about the in vivo effectiveness of a therapy targeting intraductal neoplastic cells within breast premalignant lesions. Methods: The trial designation is PINC (Preventing Invasive breast Neoplasia with Chloroquine). Current enrollment: trial opened in Jan. 2010. The planned accrual is 30 patients in each treatment arm. Patients with high grade ER positive DCIS receive tamoxifen plus CQ. ER negative patients receive CQ alone. Patients with low grade ER positive DCIS receive tamoxifen only. Eligibility: biopsy proven DCIS, grades I-III, ER positive or ER negative. MRI is performed before and after drug treatment. All patients receive standard of care surgical therapy post drug treatment. Effectiveness is measured at the molecular level and correlated with MRI data. The activated (post translationally modified) state of 59 proteins associated with autophagy, hypoxia, apoptosis, angiogenesis, invasion, and cell cycle pathways are measured by Reverse Phase Protein Microarray, before and after therapy, within the microdissected DCIS biopsy. In parallel, DCIS living organoids are harvested, cultured, and scored for a) invasive potential in autologous human breast stroma ex vivo, b) DCIS progenitor cell yield and growth, and c) growth in NOD SCID mouse xenotransplantation. Full genome molecular cytogenetics is conducted (300,000 SNPs, Illumina HumanCytoSNP profile) and correlated with MRI and protein microarray data. This trial, if successful, provides neoadjuvant therapy for all categories of DCIS and can support a future chemoprevention strategy designed to suppress occult or overt breast premalignant lesions. No significant financial relationships to disclose.
Cognitive deficits and psychopathology among former prisoners of war and combat veterans of the Korean conflict
Authors: P B Sutker, D K Winstead, Z H Galina, A N Allain
Journal: American Journal of Psychiatry (1991)

This study was conducted to describe the long-term psychological and psychiatric sequelae of prisoner of war (POW) confinement against the backdrop of psychiatric evaluations of Korean conflict repatriates more than 35 years ago.A group of 22 POWs and a group of 22 combat veteran survivors of the Korean conflict were compared on measures of problem solving, personality characteristics, mood states, and psychiatric clinical diagnoses by means of a battery of psychometric instruments and structured clinical interviews.Although the two groups were similar in background and personal characteristics, they differed in reports of life adjustment problems, complaints of physical distress, proficiency on cognitive tests, objectively measured personality characteristics, and assigned psychiatric diagnoses.Illustrated by a case report which describes the prolonged brutality of the Korean conflict POW experience for one individual, the results suggest that the psychiatric symptoms documented more than three decades ago have persisted in severity and chronicity. In addition to problems with cognitive deficits and complaints of bodily discomfort, most common among POW survivors were symptoms of suspiciousness, apprehension, confusion, isolation, detachment, and hostility.
Incisional Keloid
Authors: Ignacio Valenzuela Salas, Andrea Fernández Miralbell
Journal: New England Journal of Medicine (2015)

A 24-year-old man underwent thoracic surgery for pulmonary hydatid disease, and 8 weeks later, asymptomatic tumorlike, cutaneous lesions developed over the incision site. The patient was receiving albendazole as an adjunct therapy. A clinical diagnosis of keloid was made.