tbuckley/cabot-search huggingface dataset:
Interrupted versus Continuous Chemotherapy in Patients with Metastatic Breast Cancer
Authors: Hyman B. Muss, L. Douglas Case, Frederick Richards, Douglas R. White, M. Robert Cooper, Julia M. Cruz, Bayard L. Powell, Charles L. Spurr, Robert L. Capizzi
Journal: New England Journal of Medicine (1991)

Chemotherapy for metastatic breast cancer is palliative, and the optimal duration of therapy is unknown. We designed a trial to determine whether continuous treatment is superior to stopping treatment after a brief induction period and resuming treatment when the disease progresses.We treated 250 women with metastatic breast cancer with six courses of cyclophosphamide, doxorubicin, and fluorouracil given every three weeks. At the completion of this induction period, women whose disease either regressed or remained stable were randomly assigned to receive either continued treatment with cyclophosphamide, methotrexate, and fluorouracil (maintenance therapy) or no further treatment (observation) followed by treatment with cyclophosphamide, methotrexate, and fluorouracil when disease progression became evident (reinduction).The combined rate of complete and partial responses after initial therapy was 30 percent (71 of 233 patients who could be evaluated; 95 percent confidence interval, 25 percent to 37 percent). In another 42 percent (98 patients), the disease remained stable. A total of 145 patients were randomized. Seventy-one were randomly assigned to the maintenance-therapy group, and 74 to the observation group. The median time to progression was 9.4 months for patients in the maintenance-therapy group and 3.2 months for patients in the observation group (P less than 0.001). After reinduction therapy, the median time to progression was 3.5 months. The median length of survival from the time of initial therapy was 14.8 months for all 250 patients; it was 21.1 months for the 71 patients in the maintenance-therapy group and 19.6 months for the 74 patients in the observation group (P = 0.67). Maintenance therapy was the most important determinant of the time before progression (P less than 0.001), but it was not associated with prolonged survival. The changes in performance status were similar in the patients in both groups, but nausea, vomiting, and mucositis were significantly more frequent in the maintenance-therapy group.In patients with breast cancer who received induction chemotherapy for 18 weeks, subsequent continuous chemotherapy was associated with a significant prolongation of the time before progression as compared with those receiving no further therapy; overall survival, however, was not significantly different in the two groups.
THE IMPACT OF BLEEDING AVOIDANCE STRATEGIES ON HOSPITAL-LEVEL VARIATION IN BLEEDING RATES FOLLOWING PERCUTANEOUS CORONARY INTERVENTION: INSIGHTS FROM THE NCDR CATHPCI REGISTRY
Authors: Amit Vora, Eric Peterson, Lisa McCoy, Kirk Garratt, Michael Kutcher, Steven Marso, Matthew Roe, John Messenger, Sunil Rao
Journal: Journal of the American College of Cardiology (2016)
AB1439-HPR Assessment of quality of life of patients with juvenile idiopathic arthritis with aid of questionnaire CHQ
Authors: V. Malievsky, G. Gareeva
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Juvenile idiopathic arthritis affect essentially all parameters of quality of life of sick children, including their physical, social, and psychological functioning. <h3>Objectives</h3> We evaluated quality of life of patients with juvenile idiopathic arthritis with aid of the parental version of questionnaire CHQ. <h3>Methods</h3> There were questionnaired 103 mothers of patients and 48 mothers of healthy children at the age of 7–17 years. The parameter of evaluation of the total state of health of the patients turned out to be two times lower than that of healthy children: whereas the absolute majority of parents of healthy children evaluated their health as good or very good, the state of patients' health was evaluated as intermediate or bad. The lower parameters on the scale "The total perception of the state of health" reflected concern about the child's health. <h3>Results</h3> As compared with healthy children, in patients with juvenile idiopathic arthritis on the scale "Physical functioning", a decrease of physical possibilities was established not only during the movements requiring the higher or moderate energy expenditure, but also during walking, postural changes or self-service. The lower parameters among sick children on the scales "Psychical health" and "Self-respect" indicate the presence in sick children of whining, feeling of solitude, a decrease of self-appraisal, of the children's satisfaction with their physical possibilities, the degree of participation in the school work, interrelations in the family and with friends. Among patients with juvenile arthritides, there has been established limitation of every-day actions, school work, and games with friends not only because of physical possibilities, but also because of the emotional state, which is indicated by low parameters of the scales "The role/social limitations – physical and emotional aspects". <h3>Conclusions</h3> The performed study has revealed the lower parameters in the majority of scales characterizing the child's physical activity, the psychoemotional reaction, which indicates the lower level of the life quality in patients with juvenile idiopathic arthritis as compared with healthy children. It has been established that the quality of life depends essentially on peculiarities of the course of disease, including the expression of functional insufficiency, the degree of activity. <h3>Disclosure of Interest</h3> None Declared
Giant Condyloma Acuminatum of Buschke and Löwenstein
Authors: Alexander Kreuter, Ulrike Wieland
Journal: New England Journal of Medicine (2011)

A 45-year-old man presented with a 1-year history of discomfort when sitting. Clinical examination of the gluteal cleft revealed a locally destructive, cauliflower-like, verrucous mass measuring 15 cm in diameter. There was no associated regional lymphadenopathy.
Abstract 1478: Bone marrow mesenchymal stem cells suppress tumor cell apoptosis and are selectively recruited to early-stage tumors
Authors: Scott A. Bergfeld, Laurence Blavier, Rex A. Moats, Yves A. DeClerck
Journal: Cancer Research (2012)

Abstract Bone marrow mesenchymal stem cells (BMMSC) are recruited to primary tumors and have been reported to display pro-tumorigenic as well as anti-tumorigenic activities. However, the mechanisms behind their effect on tumor development are still unclear. We have isolated murine bone marrow aspirates and plated them on fibronectin/collagen I, which allows expansion of an adherent stromal cell population in 3-6 weeks. These cells express the CD44 hyaluronic acid receptor in the absence of hematopoietic (CD34), myeloid (CD45), and endothelial (CD31/VEGFR2) markers and display both spontaneous and inducible adipogenesis/ osteoblastogenesis in culture. 3D matrigel cultures of murine 4T1 mammary carcinoma cells revealed enhanced generation of tumor spheroids in the presence of BMMSC or their conditioned media. Conditioned media from BMMSC also increased 4T1 cell expansion in 2D monolayer cultures, with loss of this phenomenon after heat inactivation suggesting the presence of protein-based signaling. Cell cycle analysis of 4T1 cells treated with BMMSC conditioned media revealed no statistically significant change in mitotic potential in either growth (serum present) or growth-arrest (serum depleted) phase, as determined by PI staining and BrdU uptake. However, analysis of apoptosis in 4T1 cells treated with BMMSC conditioned media showed increased percentages of live cells by PI uptake and AnnexinV staining, as well as a reduction in caspase-3 and caspase-9 activation by colorimetric assay, as the cells entered growth arrest phase. Furthermore, treatment with BMMSC conditioned media preserved viability in 4T1 cells exposed to paclitaxel under no-serum conditions. Complementary studies of BMMSC tumor-directed migration indicate that BMMSC show preferential in vitro recruitment by murine tumor cell lines which generate reactive stroma (4T1, LL/2 lung carcinoma) vs. no stroma (B16 melanoma). In vivo recruitment of BMMSC by early-stage/slow-growing subcutaneous 4T1 tumors was also visualized by bioluminescent imaging, red fluorescence, and magnetic resonance imaging of BMMSC labeled with iron-nanoparticles. These results were confirmed by immunohistochemical evaluation of iron deposits by Prussian blue stain and by immunofluorescent detection of PKH26-labeled BMMSC. Overall, our data identify BMMSC as an important mediator of tumor cell survival/treatment resistance and reveal an enhanced tropism of BMMSC toward early 4T1 tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1478. doi:1538-7445.AM2012-1478
Case-Control Study on Fecapentaene Excretion and Adenomatous Polyps in the Colon and Rectum
Authors: T. M. C. M.d. Kok, D. Pachen, M. L. P. S.v. lersel, C. G. M. I. Baeten, L. G. J. B. Engeles, F. t. Hoor, J. C. S. Kleinjans
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Case-Control Study on Fecapentaene Excretion and Adenomatous Polyps in the Colon and Rectum Get access T. M. C. M.de Kok, T. M. C. M.de Kok Department of Health Risk Analysis and Toxicology, University of Limburg, MasstrichtThe Netherlands Correspondence to : T. M. C. M. de Kok, Department of Health Risk Analysis and Toxicology, University of Limburg, P.O. Box 616, 6200 MD Maastricht, The Netherlands. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Pachen, D. Pachen Department of Health Risk Analysis and Toxicology, University of Limburg, MasstrichtThe Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar M. L. P. S.van lersel, M. L. P. S.van lersel Department of Health Risk Analysis and Toxicology, University of Limburg, MasstrichtThe Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar C. G. M. I. Baeten, C. G. M. I. Baeten Department of Surgery, Academic HospitalMasstricht Search for other works by this author on: Oxford Academic PubMed Google Scholar L. G. J. B. Engeles, L. G. J. B. Engeles Department of Gastroenterology, Massland Hospital Sittard, WalramstraatThe Neatherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar F. ten Hoor, F. ten Hoor Department of Human Biology, University of LimburgMasstricht Search for other works by this author on: Oxford Academic PubMed Google Scholar J. C. S. Kleinjans J. C. S. Kleinjans Department of Health Risk Analysis and Toxicology, University of Limburg, MasstrichtThe Netherlands Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 15, 4 August 1993, Pages 1241–1244, https://doi.org/10.1093/jnci/85.15.1241 Published: 04 August 1993 Article history Received: 17 March 1993 Revision received: 25 May 1993 Accepted: 01 June 1993 Published: 04 August 1993
Abstract 2370: Single cell analysis using a microscale migration slide
Authors: Yi Zhou, Cristina Moore, Vi Chu
Journal: Cancer Research (2011)

Abstract Cell migration occurs in a variety of biological processes including wound healing, embryonic development, and immune responses. Existing chemotaxis assays used to assess cell migration employ the Boyden chamber which lack real-time imaging capability and does not maintain well defined biomolecular gradients. To overcome these limitations, a cell migration assay was developed which enabled real-time monitoring of single cells on a slide-like platform that maintained a stable linear gradient. Fluorescence measurements with albumin (MW=66kDa) conjugated with FITC demonstrated that the concentration profile was linear over the 1 mm observation area. This linear concentration gradient was established after 1 hour incubation and was stable for over 24 hours. The microscale migration slide was used to assess the effects of serum concentrations (0, 2, 5, 10, and 15%) on the migration propensity of four different cell lines that were grown on collagen. The cell lines included cancer cell lines with known invasive properties (fibrosarcoma cancer cells HT1080 and breast cancer cells MDA-MB-231), along with HUVECs which are angiogenic cells involved in tumor metastasis and a control cell line, NIH 3T3 fibroblast cells. Cells were incubated in the experimental conditions overnight (12 hours) with images captured every 15 minutes. Migration of single cells was monitored and imaged in real-time and the percentage of cells that exhibited positive migration towards the chemotactic source was calculated. Interestingly, we observed that the highest percentage of migratory HUVEC cells was obtained using 2% serum whereas the other three cell lines exhibited increased migration with increasing serum concentration. Under similar culture conditions of either 10 or 15% serum, MDA-MB-231 possessed the highest migration index, followed by NIH 3T3 fibroblasts and HT1080 cells whereas HUVEC cells did not migrate at all under these high serum conditions. Extensive testing over a range of conditions with different users indicated remarkable consistency in the data generated and suggests that the migration slide is a useful tool to monitor the effects of chemoattractants on adherent cell lines. Overall the results provide a reference point from which to build upon future studies aimed at comparing the effects of signaling molecules and growth factors on the migration propensities of cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2370. doi:10.1158/1538-7445.AM2011-2370
FRI0584-HPR Relationship between Pain and Functional Ability, Anxiety and Depression in Patients with Juvenile-Onset Systemic Lupus Erythematosus and Juvenile Idiopathic Arthritis
Authors: S.N. Baydogan, E. Tarakci, O. Kasapcopur, K. Barut
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Juvenile-onset systemic lupus erythematosus (JSLE) and Juvenile idiopathic arthritis (JIA) in children and adolescents are chronic autoinflammatory affection which might occur in any joint and has a potential to cause multisystem deteriorations. <h3>Objectives</h3> The aim of this study was to assess relationship among pain, functional ability, anxiety and depression in patients with JSLE and JIA. <h3>Methods</h3> 16 patients with JSLE and 20 patients with JIA were enrolled in the study. The subjects were recruited in a pediatric rheumatology clinic. They were diagnosed with JSLE/JIA by a pediatric rheumatologist based on the clinical diagnostic criteria. Patients with recent diagnoses of JSLE/JIA and those with mental deficits were excluded.Visual Analog Scale (VAS) was used to evaluate pain (during rest) and well being. Functional ability was evaluated with Childhood Health Assessment Questionnaire (CHAQ). Anxiety was evaluated by The Screen for Anxiety Related Emotional Disorders (SCARED) questionnaire. Also, depressive symptoms were assessed by Children9s Depression Inventory (CDI). <h3>Results</h3> The mean age was 14.81±2.22 years and 13.90±2.12 years in patients with JSLE and JIA respectively (range 12–18 years). There were no statistically significant differences (p&gt;0.05) in age, weight, height, body mass index, number of affected joint between patients with JSLE and JIA. Score of VAS-pain in patients with JSLE was more than in patients with JIA (p=0.01). Significant relationships were found between score of VAS-pain and score of VAS-well being (r=0.81 p=0.000) and score of SCARED (r=0.56 p=0.023) and score of CDI (r=0.57 p=0.019) in patients with JSLE. While significant relationships were found between score of CHAQ and score of VAS-well being (r=0.62. p=0.003) score of SCARED (r=0.64 p=0.002) and score of CDI (r=0.54 p=0.014) in patients with JIA. <h3>Conclusions</h3> Increased pain provokes anxiety, and depression by decreasing well being in patients with JSLE. On the other hand, in patients with JIA reduced functional ability results increased levels of anxiety and depression symptoms. In patients with JSLE affected joint count is lower while pain severity is more when compared to patients with JIA. Therefore, we supposed that reduction of anxiety and depression symptoms is considerable in treatment of patients with JSLE and JIA. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6043
LB0003 A Randomized Controlled Study of Laquinimod in Active Lupus Nephritis Patients in Combination with Standard of Care
Authors: D. Jayne, G. Appel, T. M. Chan, H. Barkay, R. Weiss, D. Wofsy
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Laquinimod (LAQ) is a novel oral immunomodulator in development for the treatment of Lupus Nephritis (LN). LAQ has an immune modulatory effect on antigen presenting cells directing T cells towards an anti-inflammatory phenotype characterized by down regulation of proinflammatory cytokines, including IL-6, IL-12, IL-17, IL-23, and TNFa, and increased production of IL-10. <h3>Objectives</h3> To evaluate the safety, tolerability &amp; clinical effect of LAQ vs. placebo in patients with active LN receiving standard of care (SoC; <i>i.e</i>. mycophenolate mofetil (MMF) and corticosteroids). <h3>Methods</h3> Phase IIa, multicenter, double-blind, randomized study to evaluate the safety, tolerability and clinical effect (including changes in eGFR &amp; proteinuria) of LAQ in combination with SoC. 46 patients with active LN were randomized to 24 weeks of treatment with LAQ 0.5mg/day (n=16), LAQ 1mg/day (n=15), or placebo (n=15). <h3>Results</h3> The percentage change from baseline in eGFR at week 24 was greater in both LAQ groups vs. placebo (0.5mg vs. 1mg LAQ vs. placebo: 18.0 ± 30.7 vs. 24.3 ± 28.8 vs. 12.1 ± 20.2, respectively). The percent change from baseline in spot urine protein: creatinine ratio also showed a difference between treatment arms in favor of LAQ (0.5mg vs. 1mg LAQ vs. placebo: -61.4 ± 22.8 vs. -23.0 ± 53.6 vs. -8.3 ± 81.26, respectively). Renal responses were greater at week 24 with LAQ vs. placebo (ALMS study criteria – based on spot urine instead of 24hr collection): In the LAQ 0.5mg group, 10 patients (62.5%) achieved renal response compared to 6 (40%) in the LAQ 1mg group and 5 (33.3%) in the placebo group. There was no difference among the three treatment groups in the frequency of common adverse events (AEs) including infections. Four patients in each group experienced serious AEs (SAEs). 6 SAEs were due to infection, 3 SAEs were related to lupus, 3 were thromboembolic events, and one patient with positive anticardiolipin antibodies at baseline experienced a spontaneous abortion. One death occurred in the LAQ 1mg group (pan-lobar pneumonia &amp; sepsis). There were no elevations of AST or ALT to above 3x ULN or bilirubin elevations above 2x ULN during the treatment period. <h3>Conclusions</h3> In this exploratory study of patients with active Lupus Nephritis, LAQ 0.5 &amp; 1mg in combination with SoC demonstrated an additive effect in improving renal function (as assessed by eGFR &amp; proteinuria) compared to SoC alone. Although these signals are encouraging, this small phase IIa trial was not powered to definitively establish differences among the treatment groups. Both LAQ doses appeared to be well tolerated in this group of patients. A larger study of LAQ in combination with MMF and corticosteroids compared to SoC is planned in LN patients to confirm the safety and efficacy profile observed in this study. <h3>Disclosure of Interest</h3> None Declared
P13.12 * LINAC RADIOSURGERY IN THE MANAGEMENT OF PARASAGITTAL MENINGIOMAS
Authors: U. Hadelsberg
Journal: Neuro-Oncology (2014)

BACKGROUND: At present, there is no general agreement for the best approach to parasagittal meningiomas. Invasion of the superior sagittal sinus is frequent and responsible for relatively high recurrence rates following conventional microsurgery. Radiosurgery has the potential to treat less accessible portions of these tumors and its application in this pathology is increasing both as a primary or a complementary therapeutic tool. OBJECTIVES: To evaluate our results with LINAC radiosurgery for treatment of parasagittal meningiomas METHODS: The patient cohort consisted of 74 patients treated for parasagittal meningioma by LINAC radiosurgery at the Sheba Medical Center Radiosurgery Unit during a 15-year period. Women accounted for 61% of patients. Thirteen patients,(18%) underwent radiosurgery as the primary treatment for their meningioma. RESULTS: The overall control rate was 90.6% at a mean follow up of 49 months. In 17 patients (22.9%) there was no volumetric change. Fifty patients (67.5%) showed tumor shrinkage ranging from 15-80% of the original mass. In 7 patients tumor recurrence was observed at an average time of 42.2 months after radiosurgery. All the patients with previously untreated tumors were controlled. Symptomatic transient peritumoral edema developed in 5 patients (6.7%) at a mean of 6.4 months after radiosurgery. Three patients complained of protracted headaches post treatment. CONCLUSIONS: LINAC radiosurgery was highly effective for the treatment of parasagittal meningiomas in this series. For small to medium sized meningiomas with clear invasion of the sinusal lumen, radiosurgery is a reasonable option as a first line treatment. Either alone or combined to conventional surgery, radiosurgery may improve control rate for parasagittal meningiomas.
Carcinoma of the Pinna
Authors: Paul B. Metgalf
Journal: New England Journal of Medicine (1954)

CARCINOMA of the pinna as a disease of surgical importance has received little attention in the American literature. It represents about 5 per cent of all skin cancers,1 2 3 7 per cent of epitheliomas of the head and neck3 , 4 and 25 to 33 per cent of epidermoid carcinomas of the head.4 , 5 More than half the lesions of the pinna are epidermoid carcinomas, and of these 8 to 15 per cent metastasize to the regional lymph nodes.1 2 3 4 5 6 7 8 Surgery,4 , 8 irradiation,1 , 2 , 6 various dermatologic technics3 and "chemosurgery"7 are reported to have produced three-year "cure rates" of 60.0 to 82.5 per cent, when estimated according to . . .