151P Genetic variants of vitamin D receptor gene and colorectal carcinogenesis: A cumulative meta-analysis
Authors: Y. He, N. Chen, Z. Wang
Journal: Annals of Oncology (2015)

Aim/Background: Genetic variants of Vitamin D receptor (VDR) gene could influence colorectal carcinogenesis. Numerous investigations, however, reported inconsistent results. Thus, we conducted a cumulative meta-analysis to clarify the controversy.Methods: We performed a systematic search until May 2015 in Medline, Embase and Cochrane library databases. Dominant, recessive and additive genetic models were adopted to evaluate the effect of variant allele. We pooled the data using Mantel-Haenszel method and cumulative meta-analyses were carried out to observe the variation trend of the effect size.Tabled 1Summary of meta-analysis results under additive modelVariablesFokIBsmlTaqICdx-2ApaIOR(95%CI)OR(95%CI)OR(95%CI)OR(95%CI)OR(95%CI)AdenomaRisk1.00 (0.94-1.06)0.99 (0.93-1.05)Recurrence1.00 (0.93-1.07)1.00 (0.89-1.12)CancerRisk1.00 (0.92-1.09)0.89 (0.80-0.99)*1.02 (0.88-1.18)1.10 (1.02-1.18)1.00 (0.86-1.16)Caucasian1.04 (0.98-1.09)0.86 (0.75-0.99)*1.01 (0.85-1.20)1.10 (1.02-1.18)0.96 (0.81-1.14)Asian1.02 (0.70-1.47)0.87 (0.36-2.13)*1.03 [0.83-1.28]1.13 (0.71-1.80)Colonic0.95 (0.80-1.13)0.84 (0.72-0.98)*1.20 [1.01-1.44]1.30 (0.63-2.67)Rectal0.95 (0.83-1.08)0.91 (0.75-1.11)*0.97 (0.81-1.16)SurvivalOverall0.95 (0.71-1.28)0.89 (0.67-1.18)1.16 (0.74-1.81)Cancer-specific0.98 (0.75-1.21)1.18 (0.87-1.61)0.79 (0.57-1.12)1.02 (0.59-1.76)*Results of meta-analyses under recessive model Open table in a new tab Conclusions: The Bsml variant is a protective factor for colorectal cancer risk, and the TaqI variant is a risk factor for colon cancer. The Cdx-2 variant might be associated with increased risk of colorectal cancer. Current evidence did not suggest that VDR variants could modify prognosis of colorectal cancer or adenoma. In the future, more well-designed studies exploring association between VDR variants on outcome of colorectal cancer or adenoma patients are expected to further confirm and extend our findings.Disclosure: All authors have declared no conflicts of interest. Aim/Background: Genetic variants of Vitamin D receptor (VDR) gene could influence colorectal carcinogenesis. Numerous investigations, however, reported inconsistent results. Thus, we conducted a cumulative meta-analysis to clarify the controversy. Methods: We performed a systematic search until May 2015 in Medline, Embase and Cochrane library databases. Dominant, recessive and additive genetic models were adopted to evaluate the effect of variant allele. We pooled the data using Mantel-Haenszel method and cumulative meta-analyses were carried out to observe the variation trend of the effect size. *Results of meta-analyses under recessive model Conclusions: The Bsml variant is a protective factor for colorectal cancer risk, and the TaqI variant is a risk factor for colon cancer. The Cdx-2 variant might be associated with increased risk of colorectal cancer. Current evidence did not suggest that VDR variants could modify prognosis of colorectal cancer or adenoma. In the future, more well-designed studies exploring association between VDR variants on outcome of colorectal cancer or adenoma patients are expected to further confirm and extend our findings. Disclosure: All authors have declared no conflicts of interest.