tbuckley/cabot-search huggingface dataset:
THU0480 Comparative Effectiveness of Educational Programs for Osteoporosis
Authors: L.P. Evstigneeva, O. Lesnyak
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Educational programs may be beneficial in a variety of important factors for the prevention, treatment and management of osteoporosis. <h3>Objectives</h3> To evaluate the influence of the three different educational interventions on knowledge, dietary calcium, physical activities and adherence to treatment of osteoporosis. <h3>Methods</h3> 117 patients (middle age 63.3 ± 8.1 years old, 95.7% are women) with osteoporosis have been included in this study. All patients were randomized to three groups. The patients of intervention group (n=39) had an osteoporosis school program (4 lessons with using interactive methods in groups of sevens to tens). The patients of the control group (n=38) received brochures with general information about osteoporosis. The patients of the comparison group (n=40) received lecture (1 x 1.5 h) about osteoporosis. Average changes from baseline in knowledge, dietary calcium, physical activities and time of physical exercises was evaluated in 3, 6 and 12 months. Adherence to treatment was evaluated in 12 months. <h3>Results</h3> After educational programs level of knowledge was increased in patients of the intervention group in 3, 6 and 12 months by 23,8%, 22,9%, 21,1%, in the group of brochures – by 0.5%, 1.8%, 4.7%, correspondingly, p&lt;0.01. In the group received lecture level of knowledge was increased by 18.0%, 15.8%, 14.6% (p&lt;0.05 when compared with the brochure at visits 3 and 6 months). The use of dietary calcium was increased in 3, 6 and 12 months in the intervention group by 188.5 mg, 211.8 mg and 238.1 mg, in group received lecture by 146.8 mg, 106.4 mg, 84.4 mg, in control group received brochures by 66.0 mg, 80.4 mg and 68.3 mg (p&lt;0.05 when compared intervention group with the control group at visits 3 months). Physical activity was increased in 3, 6 and 12 months in intervention group by 1.7, 1.9, 0.9 scores and was significantly higher, than in group received lecture (0.2, 0.2, 0.1 scores) and in control group received brochures (0.1, 0.2, 0 scores). Time of physical exercises was increased by 45.1, 54.2 and 49.9 min in week in the intervention group and was significantly more than in the groups received lecture or brochures. Adherence to pathogenetic osteoporosis treatment was higher in the intervention group: 56.4% of intervention group, and 30.0% of the group received lecture, and 13.2% of group received brochures took pathogenetic medication regularly during the year (p&lt;0.01 when compared the intervention group with the control group). <h3>Conclusions</h3> Educational program with using interactive methods in small groups increases knowledge about of osteoporosis, dietary calcium, physical activities and increases adherence to treatment of pathogenetic medication more than brochure and lecture. <h3>Disclosure of Interest</h3> None declared
Proteomic Exploration of the Cell Surface Landscape Reveals New Leukemia Associated Features.
Authors: Jean-Pierre Bourquin, Paulina Mirkowska, Ester Mejstrikova, Lucie Slamova, Tomasz Szczepanski, Lukasz Sedek, Maike Schmitz, Vincent H.J. van der Velden, Andreas Hofmann, Gunnar Cario, Martin Stanulla, Beat C Bornhauser, Bernd Wollscheid
Journal: Blood (2012)
A Phase I Study of Vorinostat (V) in Combination with Rituximab (R), Ifosphamide, Carboplatin, and Etoposide (ICE) for Patients with Relapsed or Refractory Lymphoid Malignancies or Untreated T- or Mantle Cell Lymphoma.
Authors: Lihua E. Budde, Michelle M. Zhang, Andrei R. Shustov, John M. Pagel, Thomas A. Warr, Tara L Chen, George R. Oliveira, Ted Gooley, Ajay K. Gopal
Journal: Blood (2009)
AB0852 Residual Pain in The Infectious Spondylodiscitis, When To Expect It?: Table 1
Authors: R. Dhahri, I. Gharsallah, N. Boussetta, R. Abid, L. Metoui, F. Laajili
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Residual pain after Infectious spondylodiscitis can result in a major handicap in social and professional life. The aim of the present work was to describe predictive factors of Residual pain after Infectious Spondylodiscitis according to the experience of an internal medicine department in Tunisia. <h3>Methods</h3> Patients with SDI either confirmed or presumed and hospitalized in the internal medicine department of The Principle Military Hospital Of Tunis, Tunisia have been included in the Study. Factors correlated with later pain are gathered in this study. <h3>Results</h3> See Table 1. Fourty-four patients met the inclusion criteria. They have been gathered over 20 years-period. They were 24 men and 20 women with an average age at 52.5 years. The diagnosis was a Tuberculous Spondylodiscitis in 22 cases (50%): among them 10 patients had a concomitant extra spinal TB. The diagnostic delay was 231 days for TB SDI and 40.5 days for SDP. Treatment duration was 13 months for SDT and 18 weeks for SDP. The outcome was favorabl Regular monitoring was observed in 38 patients (17 SDP, SDT 21) with an average duration of 20 months (5–48 months). <h3>Conclusions</h3> Neurological signs at first examination and MRI are main factors of residual pain in SDI. <h3>Disclosure of Interest</h3> None declared
CS-1 Is Expressed in Nasal Type NK/T Cell Lymphomas and Angioimmunoblastic T-Cell Lymphomas: Implications for Targeted Therapy with Elotuzumab (HuLuc63).
Authors: Eric D Hsi, Roxanne Steinle, Balaji Balasa, Audie Rice, Young-Hyeh Ko, Daniel E.H. Afar
Journal: Blood (2008)
SP0182 Is This Really Rheumatoid Arthritis?
Authors: M. Gaudé
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Whipple9s disease is a chronic, systemic, curable bacterial infection, caused by <i>Tropheryma whipplei</i> and often mistaken for rheumatoid arthritis. Indeed, the classical form usually begins with intermittent joint involvement several years before the development of weight loss and diarrhea, associated with other diverse clinical manifestations. <h3>Objectives</h3> To know the main clinical presentations of Whipple9s disease and <i>Tropheryma whipplei</i> localized infections. To consider a diagnosis of Whipple9s disease in a middle-aged man presenting with isolated intermittent arthritis before the development of chronic persistent polyarthritis and of digestive signs and symptoms. To be able to diagnose Whipple9s disease by performing <i>Tropheryma whipplei</i> polymerase chain reaction from stools, saliva and synovial fluid. To know how to interpret polymerase chain reaction tests and pathological examination results. To know the therapeutic options in Whipple9s disease according to central nervous system involvement. <h3>Methods</h3> This presentation describes a patient with a 28-year history of isolated chronic severe bilateral destructive polyarthritis. Blood tests showed elevated acute phase reactants, persistent leukocytosis, but rheumatoid factor and antinuclear antibody tests were negative. He was treated for a presumed seronegative rheumatoid arthritis. He then presented with fever, weight loss, diarrhea and adenopathy. <h3>Results</h3> <i>Tropheryma whipplei</i> polymerase chain reaction was positive from synovial fluid, synovial tissue, and lymph node specimens. Duodenal biopsy confirmed periodic acid-Schiff-positive macrophages. Whipple9s disease was diagnosed. <i>Tropheryma whipplei</i> was successfully cultivated from the synovial fluid. Antibiotic treatment was instituted in the patient, after which his symptoms remitted. <h3>Conclusions</h3> Particular attention to a diagnosis of <i>Tropheryma whipplei</i> infection is warranted in a middle-aged man presenting with unexplained isolated intermittent arthritis. <i>Tropheryma whipplei</i> polymerase chain reaction from stools and saliva should be performed. Antibiotic therapy usually ensures the full resolution of all manifestations, which can otherwise be fatal, in case of late diagnosis of extended systemic forms. <h3>References</h3> Meunier M, Puéchal X, Hoppé E,et al. Rheumatic and musculoskeletal features of Whipple disease: a report of 29 cases. J Rheumatol 2013;40:2061–6. Puéchal X. Whipple9s disease. Ann Rheum Dis 2013;72:797–803. <h3>Disclosure of Interest</h3> None declared
The Role of Angiopoietins System in Waldenstrom's Macroglobulinemia: Correlations with Marrow Microvessel Density and Survival
Authors: Efstathios Kastritis, Evangelos Eleutherakis-Papaiakovou, Maria Gavriatopoulou, Dimitrios Christoulas, Athanasios Papatheodorou, Maria Gkotzamanidou, Meletios A Dimopoulos, Evangelos Terpos
Journal: Blood (2012)
THU0267 The Oxidative Stress Markers as Risk Factor for Endothelial Dysfunction in Primary and Secondary Antiphospholipid Syndrome
Authors: L. Stojanovich, N. Stanisavljevic, D. Marisavljevic, V. Dopsaj, B. Todic
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The oxidative stress markers as risk factor for endothelial dysfunction in primary and secondary antiphospholipid syndrome. <h3>Objectives</h3> Antiphospholipid syndrome (APS) may manifest as a primary (PAPS) or as a secondary disease (SAPS). It is featured by clinical manifestations in the presence of antiphospholipid antibodies (aPL). Antioxidant status has been evaluated in patients with SLE, with conflicting results. <h3>Methods</h3> The study involved 152 APS patients (95 PAPS, 57 SAPS) and 41 age/sex-matched controls. Brachial artery responses to reactive hyperaemia (endothelium-dependent dilatation) [FMD] and sublingual nitroglycerine (endothelium-independent dilatation) [NMD] were measured by using high-resolution vascular ultrasound. Markers of oxidative stress, including lipid hydroperoxydes (LOOH), advanced oxidation protein products (AOPP), total thyol groups and paraoxonase 1 activity (PON1) were determined by spectrophotometric method. <h3>Results</h3> FMD in patients with PAPS and SAPS was significantly lower than those of the controls (p&lt;0.001 and p&lt;0.001, respectively) without difference in NMD. FMD impairment was similar in both APS groups. Risk factors for endothelial impairment were age (p&lt;0.05), obesity (p=0.048) and hypertension (p=0.020) but not aPL. We also found statistically significant difference in prevalence of FMD and NMD impairment in PAPS patients with longer disease duration. LOOH and AOPP concentrations were significantly higher and thyol groups lower in APS patients comparing to control group as the same relations between SAPS to PAPS groups. APS patients with fetal losses had higher AOPP (p=0.002) as well as patients diagnosed with thrombosis (p=0.011). Impairment of FMD was found in APS patients with higher LOOH and AOPP concentrations (p=0.044 and 0.015, respectively). There was no difference between impairment of FMD and NMD according to aPL category (except LA positivity to FMD impairment in PAPS group) or clinical APS manifestation. <h3>Conclusions</h3> Endothelial dysfunction is present in APS patients with marked oxidative imbalance. Oxidative stress is more prominent in SAPS than in PAPS group. Endothelial dysfunction is doubtlessly present in APS patients with oxidative imbalance as additional risk factor among other risk factors for clinical event. AOPP could be relevant prognostic factor for APS manifestations since it contribute to endothelial dysfunction and correlate to clinical APS manifestations. <h3>Acknowledgement</h3> This work was supported by research grant number 175041 for 2011 - 2016, issued by the Ministry of Science of the Republic of Serbia, and by research grant number TR 32040 for 2011 - 2016, issued by the Ministry of Science of the Republic of Serbia. <h3>Disclosure of Interest</h3> None declared
Urate Oxidase (Rasburicase) to Inhibit Graft Versus Host Disease (GVHD) After Myeloablative HLA-Matched Allogeneic Hematopoietic Cell Transplantation (HCT).
Authors: Andrew M. Brunner, Thomas R. Spitzer, Yi-Bin A. Chen, Erin Coughlin, Steven L. McAfee, Karen K. Ballen, Eyal C. Attar, Martin Caron, Frederic I. Preffer, Beow Y Yeap, Bimalangshu R Dey
Journal: Blood (2012)
Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression
Authors: Teresa Ramirez, Yong-Mei Li, Shi Yin, Ming-Jiang Xu, Dechun Feng, Zhou Zhou, Mengwei Zang, Partha Mukhopadhyay, Zoltan V. Varga, Pal Pacher, Bin Gao, Hua Wang
Journal: Journal of Hepatology (2016)
HLA Locus-Specific Outcomes in Double Umbilical Cord Blood Reduced Intensity Transplantation (DCBT) in Adults.
Authors: Meghan Delaney, Beow Yeap, Richard L. Haspel, Thomas R. Spitzer, Steven L. McAfee, Bimalangshu Dey, Eyal Attar, Grace Kao, Edwin Alyea, Stephanie Lee, Corey Cutler, Vincent Ho, Robert J. Soiffer, Joseph H. Antin, Ballen Karen
Journal: Blood (2007)
PWE-095 Fit Sample Stability for Haemoglobin-Positive Faeces Using Two Analytical Systems Over Seven Days: Abstract PWE-095 Table 1
Authors: C Piggott, P McDonald, C John, H Bruce
Journal: Gut (2016)

<h3>Introduction</h3> Automated quantitative faecal immunochemical test (FIT) for haemoglobin (Hb) systems include a faecal sampling device (with preservative buffer), laboratory analyser and reagent kit. In colorectal cancer screening programmes faecal samples are usually collected at home and posted back to the laboratory for testing. We investigated the likely effect of sample return time on Hb concentration using naturally Hb-positive faeces and two FIT systems. <h3>Methods</h3> Eight Hb-positive faecal samples were taken from stools provided for calprotectin analysis and mixed for two minutes using wooden mixing sticks to distribute Hb. Up to 10 days elapsed before loading into sampling devices. FIT devices were loaded with faeces according to manufacturers’ instructions for all eight samples in quadruplicate for the FOB Gold (Sentinel Diagnostics) and OC-Sensor Autosampling Bottle 3 (Eiken Chemical Co.). After mixing and incubation for 2–3 hours at room temperature, Hb was measured using the SentiFIT 270 and OC-Sensor PLEDIA analysers, respectively. Two of the sampling devices for each sample were stored at 19<sup>o</sup>C (15–23<sup>o</sup>C) and two at 6<sup>o</sup>C (4–8<sup>o</sup>C) for seven days. After mixing and allowing the 6<sup>o</sup>C samples to warm to room temperature, Hb was re-measured on days 3, 5 and 7. Samples were also prepared using the Extel Hemo Auto MC Collection Picker/HM-JACKarc system (Kyowa Medex Co. Ltd.) but results are not included here due to pre-analytical sample preparation errors. <h3>Results</h3> The percentage difference of the mean of the duplicate results from day 0 to days 3, 5 and 7 was calculated. <h3>Conclusion</h3> Changes in Hb concentrations over seven days showed variation for both FIT systems, possibly due to differences in Hb degradation over time, or differences in individual portions of faeces that are loaded into the sampling devices and the time taken for Hb to move from the sampling stick to the buffer. The average, minimum and maximum percentage differences for the FOB Gold/SentiFIT 270 were lower than the OC-Sensor Autosampling Bottle 3/PLEDIA, possibly due detection of different Hb degradation products over time. Further work is needed to assess whether samples prepared sooner after collection would show the same differences. <h3>Disclosure of Interest</h3> None Declared
OP0048 IL-31 Is An Inflammatory Pro-Fibrotic Factor Elevated in A Subset of Scleroderma Patients with Severe Pruritus
Authors: N. Arumalla, S. Zafar, H. Rosario, B. Ahmed Abdi, Z. Taki, C. Denton, D. Abraham, R. Stratton, N. Mazumder, O. Etomi, A. Mohamed, F. Xing
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune rheumatic disease associated with fibroblast activation in the skin and visceral organs. In SSc, refractory pruritus is a common symptom in a subgroup of patients. IL-31 is a Th2 cell derived cytokine implicated in severe itch in other conditions including atopic dermatitis and T cell lymphoma. T-lymphocyte-derived factors provide a possible link between autoimmune inflammation and fibrosis reported in SSc. In this study we measured IL-31 levels in SSc tissue fluid and plasma, and sought correlation with itch severity and clinical parameters. Recombinant IL-31 was found to influence fibroblast and fibroblast precursor activity. <h3>Methods</h3> IL-31 was measured by ELISA of dermal tissue fluid samples obtained by a suction blister analysis method from the involved skin of SSc patients or matched site of healthy controls (SSc n=28, controls n=15), and matched plasma samples. IL-31 receptor mRNA expression was assayed by qPCR of SSc and control fibroblast lysates, as well as epithelial tissue biopsy samples. Normal skin fibroblasts as well as fat derived mesenchymal stem cells (MSCs) were treated with IL-31 (50 ng/ml) and migratory and fibrotic responses were assayed. <h3>Results</h3> IL-31 levels were increased in dermal interstitial fluid in SSc patients compared to controls (mean of 99.4 pg/ml vs 2.3 pg/ml in controls, P&lt;0.0003) and in plasma samples (mean plasma IL-31 1370 vs 196 pg/ml, P&lt;0.01). Dermal fluid IL-31 levels correlated strongly with itch severity in these patients R=0.72, P&lt;0.0038). Raised blister fluid IL-31 was characteristic of a subgroup of SSc patients with severe pruritus, which included individuals from both limited and diffuse SSc clinical subsets. Both normal and disease fibroblast extracts contained IL-31 receptor mRNA (qPCR relative copy number 6.4 SSc vs 1.4 controls, p&lt;0.01) which was also seen in epidermal tissue extracts (qPCR 18.4 SSc vs 8.2 in control, p NS). Treatment of normal dermal fibroblasts with IL-31 led to induction of type I collagen but not CTGF, and promoted fibroblast and MSC migration dependent on ERK and PI3kinase pathways. <h3>Conclusions</h3> This is the first analysis of IL-31 in systemic sclerosis and we have shown increased expression in the skin and plasma of a subgroup of SSc patients, correlating with severe itch. IL-31 protein induced fibroblasts and MSCs and may link T-cell autoimmune responses to fibroblast and precursor cell activation in SSc. Blocking IL-31 therapeutically may provide effective treatment in a subgroup of SSc patients identified clinically by severe pruritus. <h3>Disclosure of Interest</h3> None declared
Sex Chromosome Loss May Represent a Disease-Associated Clonal Population in Chronic Lymphocytic Leukemia (CLL),
Authors: Iléana Antony-Debré, Nathalie Marchay, Christophe Parizot, Elise Chapiro, Ong Anh Cung, Stéphanie Mathis, Aurore Grelier, Karim Maloum, Sylvain Choquet, Frederic Davi, Zahia Azgui, Madalina Uzunov, Veronique Leblond, Hélène Merle-Beral, Laurent Sutton, Florence Nguyen-Khac
Journal: Blood (2011)
HCP-13PATTERN OF CARE AND OUTCOME OF ANAPLASTIC OLIGODENDROGLIOMAAND OLIGOASTROCYTOMA IN A KOREAN POPULATION: THE KOREAN RADIATION ONCOLOGY GROUP STUDY 13-12
Authors: In Ah Kim, Tosol Yu, Hyun-Cheol Kang, Do Hoon Lim, Il Han Kim, Woong-Ki Chung, Chang-Ok Suh, Byung Ock Choi, Kwan Ho Cho, Jae Ho Cho, Jin Hee Kim, Do-Hyun Nam, Chul-Kee Park, Yong-Kil Hong
Journal: Neuro-Oncology (2015)

We analyzed clinical data of 376 patients with histologically confirmed anaplastic oligodendroglioma or anaplastic oligoastrocytoma (AOA) from 2000 to 2010. Post-operative therapy was performed in 354 patients (94.1 %), of which 133 received radiotherapy (RT) alone and 189 received both RT and chemotherapy. The use of procarbazine, lomustine, and vincristine (PCV) decreased (57.6 % in 2000-2001 vs. 28.6 %in 2010) and the use of temozolomide (TMZ) increased (0 % in 2000-2001 vs. 61.9 % in 2010) over the study period. A combination of chemotherapy and RT was used more often than RT alone in young patients and patients with a good performance status. The 1p/19q co-deletion status and O-6-methyguanine-DNA methyltransferase methylation were analyzed since 2004. Among the patients who received chemotherapy, TMZ was used more often in patients with AOA and PCV was used more often in patients with the 1p/19q codeletion. Median progression-free survival (PFS) was 2.9 years and overall survival (OS) was 8.7 years. (5-year and 10-year OS rates were 58% and 45%, 5-year and 10-year PFS rates were 38% and 24%). Younger age, frontal lobe location of the tumor, gross total removal, 1p/19q codeletion, and initial RT were associated with longer PFS and OS rates. A clear improvement in progression-free and overall survival was observed for RT and combined CT/RT in compared with CT only. Postoperative RT appears to improve survival for entire group thus total removal and 1p/19q codeletion may not be sufficient criteria to omit RT as a treatment option. These results suggest that RT should continue to be offered as the standard treatment option. Taken together, treatment pattern for oligodendroglial tumors changed significantly across the study period in Korea. In particular, TMZ has replaced PCV, and the use of molecular markers as well as RT alone has increased, but a optimal therapeutic option remains to be defined though the prospective randomized studies.
Intensive vs Standard Blood Pressure Control for Older Adults
Authors: Dae Hyun Kim
Journal: JAMA (2016)

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A Case of Back Pain That Wakes a Child From Sleep
Authors: Arda Hotz, Zachary Hena, Elissa Gross
Journal: JAMA Pediatrics (2016)

An 11-year-old boy with history of asthma and constipation presented with 6 weeks of intermittent, worsening lower back pain. His pain was mild to moderate, woke him from sleep, and limited his physical activity. What is your diagnosis?
Intravenous (IF) Aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (MCC): Results of a multinational phase III trial (EFC10262-VELOUR)
Authors: E. Van Cutsem, J. Tabernero, Radek Lakomý
Journal: Annals of Oncology (2011)