tbuckley/cabot-search huggingface dataset:
SP0112 Current Evidence for the Treatment of Juvenile Dermatomyositis
Authors: N. Ruperto
Journal: Annals of the Rheumatic Diseases (2015)

Juvenile dermatomyositis (DM) is a chronic disease that, like its adult equivalent, primarily affects skin and muscles. Despite improved disease outcomes with treatment strategies used over the last few decades, it is still associated with significant morbidity and mortality. Treatment for both children and adults is based on case reports and retrospective studies since very few controlled trials, conducted in small patient populations, have been performed There is strong clinical consensus that corticosteroids represent the first-line treatment of choice for juvenile DM. In steroid resistant or steroid dependent cases, an immunosuppressive drug is added as steroid sparing agent. The choice of the immunosuppressive agent relies mostly on the experience of the physician and varies widely between countries. Two of the most common immunosuppressors used in the treatment of juvenile DM are methotrexate and cyclosporine. It has however been suggested that a more aggressive therapy combining steroids and an immunosuppressive drug at disease onset could result in a better outcome. Recently the Paediatric Rheumatology International Trials Organisation (PRINTO) completed a randomized clinical trial in order to establish if, in newly diagnosed juvenile DM cases, combined treatment with steroids and methotrexate or steroids and cyclosporine has a safety and an efficacy profile which is superior to steroid monotherapy. The trial showed that combined therapy with prednisone and either cyclosporine or methotrexate was more effective than prednisone alone. The safety profile and the steroid sparing effect favored the combination of prednisone + methotrexate. The current evidence from the literature for the treatment of juvenile DM will be revised. <h3>Disclosure of Interest</h3> N. Ruperto Grant/research support from: Abbott, BMS, "Francesco Angelini", GlaxoSmithKline (GSK), Hoffman-La Roche, Italfarmaco, Janssen, Novartis, Pfizer, Sanofi Aventis, Schwarz Biosciences, Sobi, Xoma, Wyeth. The Gaslini Hospital, which is the public Hospital where I work as full time public employee, has received contributions from the industries mentioned in this section. This money has been reinvested for the research activities of the hospital in a fully independent manners besides any committment with third parties., Consultant for: Honoraria for consultancy: Abbott, AbbVie, Amgen, Biogenidec, Astellas, Alter, AstraZeneca, Boehringer, BMS, CD-Pharma,Celgene, CrescendoBio, EMD Serono,Hoffman-La Roche, Italfarmaco, Janssen, MedImmune, Medac, Novartis, Novo Nordisk, Pfizer, Sanofi Aventis, Servier, Takeda, Vertex.,, Speakers bureau: Abbott, AbbVie, Amgen, Biogenidec, Astellas, BMS, CD-Pharma, Hoffman-La Roche, Pfizer
Letter to the Editor: Outbreaks caused by parvovirus B19
Authors: B  J Cohen
Journal: Eurosurveillance (2005)

In response to the recent report of school outbreaks of parvovirus B19 infection in Portugal [1], Heath Kelly and Jennie Leydon of the Western Pacific Regional Measles Laboratory, have echoed the call for parvovirus B19 tests to be included in measles and rubella surveillance
SP0174 Physical Exercise as a Dmard in Myositis
Authors: L. Alemo Munters
Journal: Annals of the Rheumatic Diseases (2015)

Physical exercise is recommended to be combined with pharmacological treatment for patients with myositis. Physical exercise is capable of inducing both beneficial systemic and local skeletal muscle adaptations and has an indirect potential to improve comorbidities such as cardiovascular risk factors and the metabolic syndrome. During this session, current evidence on disease modifying effects of physical exercise in patients with myositis will be presented. Also, specific molecular mechanisms underlying beneficial adaptations in skeletal muscle to physical exercise in these patients will be discussed. Take home messages: Physical exercise added to pharmacological treatment has a potential to reduce clinical disease activity in established myositis, as well as improve muscle performance potentially by improved aerobic capacity. Exercise improves the aerobic milieu in skeletal muscle in patients with myositis. Gene expression and proteomic analysis of exercised skeletal muscle from patients with myositis identified specific molecular adaptations such as activation of the aerobic phenotype including mitochondrial oxidative phosphorylation, mitochondrial biogenesis and capillary growth. Also, activation of the muscle growth program and suppression of the inflammatory response in muscles were identified. Recent findings, after 12 weeks of endurance exercise in patients with myositis, support increased fat metabolism during exercise in skeletal muscle, concurrent with reduced systemic insulin resistance. These metabolic observations may be important as an indirect anti-inflammatory effect of physical exercise in myositis. Supported exercise in recent-onset myositis is safe and does not aggravate inflammatory pathways. In contrary, early introduced exercise may have long term beneficial effects. <h3>Disclosure of Interest</h3> None declared
Immunological Aspects of Transplantation Surgery.
Journal: Annals of Internal Medicine (1975)

lecture and discusses in detail the evolution of concepts relating to this association over the last fifteen years.It is peppered with case histories, illustrated by photographs of people who the author considers contributed significantly to the subject; and, as might be expected, there is an exhaustive bibliography.Furthermore, the prob- lem of watery diarrhoea syndrome is also dealt
Is Occipital Cortex a Valid Reference Region in 123I-FP-CIT SPECT Imaging?
Authors: Juho Joutsa, Jarkko Johansson, Valtteri Kaasinen
Journal: Clinical Nuclear Medicine (2015)

Joutsa, Juho MD, PhD; Johansson, Jarkko MSc; Kaasinen, Valtteri MD, PhD Author Information
p15s (15-kD Antimicrobial Proteins) Are Stored in the Secondary Granules of Rabbit Granulocytes: Implications for Antibacterial Synergy With the Bactericidal/Permeability-Increasing Protein in Inflammatory Fluids
Authors: Kol Zarember, Peter Elsbach, Kwang Shin-Kim, Jerrold Weiss
Journal: Blood (1997)
ALFRED BARING GARROD
Authors: J H TALBOTT
Journal: JAMA (1964)

Gout and Garrod have been linked in medical literature for more than a century. This distinguished London physician, born in 1819 at Ipswich, identified uric acid as a normal constituent of the serum of healthy persons and devised a method for detecting its increased concentration in gouty subjects. Alfred attended the local grammar school and, after an apprenticeship with Mr. Charles Hammond, surgeon to the East Suffolk Hospital, entered University College Hospital, London, where he received the MD degree in 1843. He placed first in the examinations and was awarded the Galen medal for botany by the Society of Apothecaries. Loyalty to the University College Hospital continued in his postgraduate years, and he enjoyed the ascending progression of responsibility, beginning as assistant physician and ending as full physician and professor of therapeutics and clinical medicine. His "Observations on Certain Pathological Conditions of the Blood and Urine, in Gout, Rheumatism, and
AB1240-HPR Turkish Version of the Short Version of the Pain Anxiety Symptom Scale (PASS-20) and its Test-Retest Reliability and Validity: Preliminary Report
Authors: P. Kisacik, G. Devesan, G. Arin, E. Unal
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Regarding to determine pain-related anxiety of patients in clinical trials, there are sufficient number of tools in the literature (1). On the other hand there is a lack of internationally accepted measures which adapted in Turkish population to assess pain-related anxiety. <h3>Objectives</h3> The aim of this study was to translate the short version of the Pain Anxiety Symptom Scale (PASS-20) into Turkish, assess its test-retest reliability and validate the use of PASS-20 among patients. <h3>Methods</h3> 47 patients with different rheumatic diseases (ankylosing spondylitis, rheumatoid arthritis…) aged between 21-71 years (mean 47.91±48.00 years) participated in this study. Translation/re trans-lation of the English version of the PASS-20 was done blindly and independently by four different individuals and adapted by a team. After the translation, 34 patients was performed Turkish PASS-20 with an interval of a week for the test/retest reliability. And also, all patients were asked to fill Tampa Kinesiophobia Scale (TKS) (2)and Beck Anxiety Scale (BAS) (3)for validation. <h3>Results</h3> There was no difference between test and retest results (p&gt;0.05). The test-retest reliability was found to be 0.864 (95% CI=0.706-0.937). Cronbach9s alpha was 0.864. Construct validity, tested by determining the correlation between the Turkish PASS-20 and the Turkish adaptation of the TKS (r=0.554, p&lt;0.01), and BAS (r=0.545, p&lt;0.01). <h3>Conclusions</h3> Test-retest reliability of the Turkish version of the PASS-20 was found to be good in our study and it was seen that this scale could be used in clinics for patients with rheumatic diseases. This study is considered as a preliminary report in terms of validation of the PASS-20 because of the lack of participated patients number. However, pre-results indicates that PASS-20 scale is usefull for rheumatic patients with pain in Turkey. <h3>References</h3> McCracken LM, Dhingra L. A short version of the Pain Anxiety Symptoms Scale (PASS-20): preliminary development and validity. Pain research &amp; management: the journal of the Canadian Pain Society = journal de la societe canadienne pour le traitement de la douleur. 2002;7(1):45-50. Tunca Yılmaz Ö, Yakut Y, Uygur F, Uluğ N. Tampa Kinezyofobi Ölçeği9nin Türkçe versiyonu ve test-tekrar test güvenirliği Fizyoter Rehabil 2011;22(1):44-9. Ulusoy M, Sahin NH, Erkmen H. Turkish Version of the Beck Anxiety Inventory: Psychometric Properties. Journal of Cognitive Psychotherapy. 1998;12(2):163. <h3>Disclosure of Interest</h3> None declared
Low-Tidal-Volume Ventilation
Authors: Yusuke Asakura, Toru Komatsu
Journal: New England Journal of Medicine (2007)

We read with interest your article on protective mechanical ventilation in Severn and Essex Critical Care units. 1At Blackpool Teaching Hospital, we are currently participating in a local network quality improvement project called 'Blow Low', aimed at improving our unit compliance with low tidal volume lung protective ventilation methods.Baseline data in our unit showed that approximately 50% of patients were receiving tidal volumes in excess of 7 ml/kg of predicted body weight.Although we have good evidence to suggest lung protective ventilation should perhaps be the best practice in all patients, 2-4 we were not unique in having problems translating this into standard practice over a decade after publication of the ARDSnet trial. 4We would like to share our success following a regional level Quality Improvement project, the 'Blow Low' campaign, the catchy memorable title being key to raising awareness among staff in our unit.The aim of the campaign was to ensure patients without contraindications received low tidal volume ventilation of 6-7 ml/kg with a target to reduce breaches of this tidal volume to less than 20% of total ventilated hours per patient.We used a continuous quality improvement methodology of plan-do-study-act (PDSA) cycles 5 to help drive the change in our unit.During the first cycle, our interventions involved:
Fast-Food Fare
Authors: C Roberts
Journal: New England Journal of Medicine (1989)

Fast-food restaurants are here to stay and are gaining patronage.1 But how nutritious are the meals they serve? How should health care professionals discuss the consumption of fast foods with patients and their families responsibly yet practically?Every second, an estimated 200 people in the United States order one or more hamburgers.2 The U.S. National Restaurant Association estimates that on a typical day, 45.8 million people — a fifth of the American population — are served at fast-food restaurants.3 The fast-food industry boasts phenomenal growth. From 1970 to 1980, the number of fast-food outlets increased from 30,000 to 140,000, and . . .
THU0285 The Association of Giant Cell Arteritis and its Histopathology with all-Cause and Cardiovascular Mortality: Table 1
Authors: G. Tomasson, J. Björnsson, Y. Zhang, V. Gudnason, P.A. Merkel
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> There is scant information on how histopathology findings are associated with outcomes of patients with giant cell arteritis (GCA). <h3>Objectives</h3> To measure the effect of GCA and its histopathology on all-cause and cardiovascular mortality within a population cohort with detailed information on temporal artery biopsies (TABs). <h3>Methods</h3> Data from the Reykjavik Study (RS), a population-based study focused on cardiovascular disease, were used. Residents who lived in the greater Reykjavik area in 1967 and were born between 1908 and 1935 were invited to join the study. Subjects who underwent TAB prior to their initial RS visit were excluded. GCA status was defined from examination of TAB by a single expert pathologist by re-examination of all TAB obtained from members of the RS cohort. Original histological diagnosis was obtained from the original pathology report. Level of inflammatory intensity in TABs consistent with GCA was visually graded as mild, moderate, or severe. Subjects were followed from study visit or age 50, whichever occurred later, until death or December 31, 2008, whichever came first. Cardiovascular mortality was assessed from death certificates. Subjects contributed unexposed person-time until they met diagnostic criteria for GCA. Effect of GCA and levels of inflammatory intensity on mortality risks compared to those who did not undergo TAB is expressed as incidence rate ratios (IRR) with 95% confidence intervals (CI) standardized by age and sex. <h3>Results</h3> Of 19,196 subjects (51% women) who came for a RS study visit from 1967 to 1994, 692 underwent TAB (71% women) and 196 had GCA (70% women). At study visit the mean age was 54.3 (8.7) years. Mean age of subjects with GCA at the time of TAB was 73.3 (6.8) years. The median follow-up time was 7.1 (IQR: 3.5-12.4) years for subjects after the diagnosis of GCA and 24.3 (IQR: 17.6-29.8) years for referent subjects, respectively. GCA was associated with an increased all-cause (IRR=1.45, 95% CI: 1.20-1.75) and cardiovascular (IRR=1.50, 95% CI: 1.13-1.99) mortality. Subjects with GCA per review of biopsy but who had an original TAB pathology report read as negative for GCA and those with mild inflammatory intensity has substantially elevated mortality risks (Table). <h3>Conclusions</h3> GCA is associated with modest increases in both all-cause mortality and cardiovascular mortality, driven by patients whose original TAB was reported as negative (and in Iceland therefore, likely not treated for GCA). The level of inflammation seen on TAB is inversely associated with mortality risks <h3>Disclosure of Interest</h3> None declared
SAT0264 Influence of Exercise in Recent Onset Axial Spondyloarthritis:Results Esperanza Cohort
Authors: R. Almodovar, V. Navarro-Compán, E. Moreno, J. Sanz, P. Zarco
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Currently, it has been seen that many of the symptoms and limitations of the spondyloarthritis (SpA) may improve with exercise. To determine the influence of exercise in our population with early axial SpA, our group decided to analyze possible differences <h3>Objectives</h3> Analyze the existence of clinical differences, image, quality of life, work disability and treatment among patients with early axial SpA who exercise compared to those who did not. <h3>Methods</h3> Baseline data from ESPERANZA program (&lt;45 years old, symptoms duration 3-24 months and with inflammatory back pain -IBP- or asymmetrical arthritis or spinal/joint pain plus ≥1 SpA features) was used for a descriptive analysis. Patients fulfilling the ASAS classification criteria for axial SpA were included. Socio-demographic and disease characteristics, disease activity indices (ESR, CRP, BASDAI, BASFI), quality of life (ASQoL), imaging (total BASRI, radiographic sacroiliitis –NY criteria- and sacroiliitis on MRI -ASAS criteria-), work disability and NSAIDs treatment were compared between patients with early axial SpA who exercise compared to those who did not. The practice of physical exercise was defined as the patient confirmed in the consultation as part of your regular routine. <i>Analysis:</i> Chi square was used to compare rates and Student-t test to analyze continuous variables. <h3>Results</h3> A total of 291 early axial SpA (191 men and 100 women) with a mean age of 32±7 years and a mean disease duration of 13±6.7 months were evaluated. The prevalence of patients with axial SpA who performed exercise was 44% (127). In patients with axial SpA practicing physical exercise statistically significant differences compared to those who did not perform physical exercise as to be found: increased presence of inflammatory bowel disease (5.5% vs 1.1%; p=0.04); lower ESR although within the normal range (10.2±11.1 vs 16.5±14.7; p=0.001) and more NSAIDs (92% vs 73%, p&lt;0.01). There were no significant differences in the others parameters studied between the two groups. <h3>Conclusions</h3> Less than half of our patients with early axial SpA exercisers at the time of diagnosis. The group of patients who performed regular exercise had a higher frequency of inflammatory bowel disease and greater use of NSAIDs, interestlingly. <h3>Disclosure of Interest</h3> None declared
Perceptual and cognitive abnormalities in bulimia
Authors: P S Powers, R G Schulman, A A Gleghorn, M E Prange
Journal: American Journal of Psychiatry (1987)

The authors compared 55 bulimic subjects and 55 normal control subjects using the Beck Depression Inventory, a new scale designed to detect cognitive distortions (the Bulimia Cognitive Distortion Scale), and several perceptual and attitudinal measures of body image. There were significant differences between the bulimic and control groups on all measures except estimates of face width. These findings are discussed in terms of a multifactorial theory of the psychopathogenesis of bulimia.
OP0046 Cause-Specific Mortality in Rheumatoid Arthritis – A Nationwide Cohort Study: Table 1
Authors: J. Lindhardsen, M. Faurschou, G.H. Gislason, L. Dreyer
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Increased mortality among rheumatoid arthritis (RA) patients has been recognized for many decades, and some studies suggest a widening mortality gap between RA patients and the general population. The excess mortality has often been linked to a higher incidence of cardiovascular disease (CVD), but in several studies the increased mortality risk from CVD equalled the overall mortality, which suggests that other factors are important. <h3>Objectives</h3> To analyse cause-specific mortality data from a recent nationwide population-based RA cohort. <h3>Methods</h3> Through linkage of nationwide individual-level administrative registers we identified the entire Danish population alive on January 1, 1995 and aged &gt;18 years. The cohort was followed to time of death, emigration or December 31, 2011. RA diagnosis were defined by a combination of relevant discharge and outpatient codes (The National Patient Register) and initiation of DMARD therapy. Primary cause of death was available from the National Cause of Death Register. Mortality rate ratios (MRRs) were calculated by poisson regression controlling for sex, age and calendar time. <h3>Results</h3> From a total of 5.3m Danish residents included in the cohort, 25 104 developed RA during follow-up (mean age at diagnosis 58.5 [SD 14.9] years; 69.9% women). Table 1 shows mortality data for RA patients compared to the general population for main causes of death. All-cause mortality in RA patients was increased by 39%. Deaths from CVD and cancer were common and conferred an almost identical impact on death rates, but with lower MRRs than the overall RA MRR. Conversely, deaths due to infection were more than twice as common among RA patients than in the general population causing a relatively high number of excess deaths (224) compared to CVD (279) and cancer (271) despite 3-4 times lower incidence. Generally, cause-specific MRRs were higher in younger patients, however, significant interaction with age were only noted with lung- and cancer-related deaths. No significant differences in MRRs between sexes, calendar time or follow-up were found. <h3>Conclusions</h3> In this nationwide Danish contemporary cohort of RA patients followed for up to 17 years, we found the mortality to be increased by 39% compared to the general population without indications of changes over time. As in the general population, cancer- and CVD-related deaths accounted for the largest proportion of deaths in RA patients but lung disease and, in particular, infections contributed relatively more to the increased mortality. These results indicate that the higher mortality in RA patients is not particular driven by CVD or cancer, but may reflect a general increased biological ageing and possibly treatment related disease. <h3>Disclosure of Interest</h3> None declared
Combined percutaneous retrograde and peroral antegrade esophagoscopy for the treatment of complete upper esophageal obstruction
Authors: Christian Lange, Bernd Kronenberger, Johannes Hausmann, Stefan Zeuzem, Jörg Albert
Journal: Endoscopy (2015)

Complete upper esophageal obstruction is a rare but significant complication of, for example, radiotherapy or caustic ingestion. It may be resolved by endoscopic techniques [1] [2] [3] [4]. Here, we report three patients with complete or nearly complete upper esophageal obstruction after curative radiochemotherapy for head and neck cancers, in whom classic peroral insertion of a guidewire for esophageal dilation failed. However, in all of these patients, esophageal stenosis was successfully treated by the combinination of a percutaneous retrograde and a peroral antegrade endoscopic approach.
Endosonographic Features of Gastric Adenomyoma, a Type of Ectopic Pancreas
Authors: M Matsushita, H Takakuwa, A Nishio
Journal: Endoscopy (2003)

We read with great interest the article by Chu [1] on an endoscopic ultrasound (EUS) appearance of gastric adenomyoma. He described for the first time the EUS appearance in a case of a 1.5 cm submucosal nodule in the gastric antrum. EUS showed that the nodule was related to the submucosa (the third echo layer), with a cystic center lined with a hyperechoic rim. After the nodule was resected laparoscopically, the resected specimen revealed features of adenomyoma.
Small-Bowel Hemangiosarcoma and Capsule Endoscopy
Authors: F.  K.  Knop, M.  B.  Hansen, S.  Meisner
Journal: Endoscopy (2003)

Capsule endoscopy is emerging as a sensitive technique for evaluating chronic gastrointestinal bleeding, and it appears to have better diagnostic yields than push enteroscopy, for example [1]. Bleeding sites in the small bowel are often difficult to detect using conventional radiological or scintigraphic techniques, and this sometimes makes laparotomy or surgical intervention necessary [2] [3]. With capsule endoscopy, it is now possible to visualize small-intestinal bleeding sites beyond the range of regular endoscopes [4]. We present here the first capsule endoscopy images of a small-bowel hemangiosarcoma causing chronic gastrointestinal bleeding.