tbuckley/cabot-search huggingface dataset:
Unusual Sites of Metastatic Involvement
Authors: M.R.M. Jongbloed, B.L.J. Kanen, M. Visser, H. Niessen, M.J. Flens, R.J.L.F. Loffeld
Journal: Journal of Clinical Oncology (2004)

The incidence of hepatocellular carcinoma in Taiwan is higher than in western countries.The higher prevalence of hepatitis B carriers in Taiwan, along with its association with chronic hepatitis, cirrhosis of the liver, and hepatocellular carcinoma, may account for the higher incidence of liver cancer in this country [1,2].Right ventricular metas-tasis is extremely rare in cases of hepatocellular carcinoma.It was only reported in four other cases during the past 20 years [3,4].Earlier, a case of carcinoma of the liver with sudden death as a result of cardiac involvement was reported [5].The first echocardiographic diagnosis of right ventricle metastasis of hepatocellular carcinoma was reported in 1980 [6].To the best of our knowledge, our case is the first patient who was treated with open-heart surgery to remove a hepatocellular carcinoma that had metastasized to the right ventricle.Successful treatment by transcoronary chemoembolization in a patient with right ventricle metastasis of hepatocelluar carcinoma was published in 2000 [3].However, in our case, the huge size of the tumor and its extensive infiltration of the free wall of the right ventricle raised the concern that myocardial necrosis and free wall rupture might have developed if transcoronary chemoembolization was carried out.The surgical resection of the isolated intracardiac tumor under cardiopulmonary bypass is safe and very likely to relieve symptoms and extend the life span of the patient.
NHS’s long term future will rely on EU trained professionals, peers are told
Authors: Adrian O’Dowd
Journal: BMJ (2016)

Workforce experts have warned that the long term future of the NHS depends on the input of health professionals trained in the European Union, regardless of how the United Kingdom leaves the EU.

Peers on the House of Lords’ NHS sustainability committee heard of the vital role played by overseas trained doctors and nurses in the NHS, during an evidence session held on 1 November for their inquiry into the long term sustainability of the NHS.

Peers asked whether the witnesses’ organisations were preparing for the UK’s decision to leave the EU and what effect this might have on the NHS workforce and possible staff shortages.

Danny Mortimer, chief executive of NHS Employers, the body that represents the …
Targeting Integrin a4b7-Expressing T-Cells in Steroid Refractory Intestinal GvHD
Authors: Yngvar Floisand, Knut Lundin, Vladimir Lazarevic, Jorn Dehli Kristiansen, Liv T. N. Osnes, Geir E. Tjonnfjord, Henrik Mikael Reims, Tobias Gedde-Dahl
Journal: Blood (2015)
Optimal duration of dual antiplatelet therapy after stent implantation in patients with or without diabetes
Authors: Jocasta Ball
Journal: BMJ (2016)

Shorter may be better

A topic of much research and debate within cardiology has been the optimal duration of dual antiplatelet therapy (DAPT) with aspirin plus a P2Y12 inhibitor to prevent stent thrombosis and further atherosclerotic progression after percutaneous coronary intervention and implantation of a drug eluting stent. Recently, large randomised controlled trials and observational studies have been conducted in an attempt to determine the optimal duration of DAPT, but the results were conflicting or inconclusive.1 2 3 4 5 6 7 Indicative of the implications, this area of cardiovascular research has had an effect on a broad range of clinical practice guidelines.8 9 10 11 The common consensus among experts has been that there is no “one size fits all” approach and no common rule for the duration of DAPT after placement of a drug eluting stent, but it is likely to be a case of “the longer the better.” The current recommendation is for 12 months of DAPT, but there are claims that this is actually of uncertain value.12

The study by Gargiulo …
Long-Term Outcomes and Safety of Continuous Lenalidomide Plus Dexamethasone (Len+Dex) Treatment in Patients (Pts) with Relapsed or Refractory Multiple Myeloma (RRMM)
Authors: Meletios Athanasios Dimopoulos, Mohamad Hussein, Arlene S Swern, Donna M. Weber
Journal: Blood (2011)
Iκ<scp>BNS</scp> induces Muc5ac expression in epithelial cells and causes airway hyper‐responsiveness in murine asthma models
Authors: M. Yokota, T. Tamachi, Y. Yokoyama, Y. Maezawa, H. Takatori, A. Suto, K. Suzuki, K. Hirose, K. Takeda, H. Nakajima
Journal: Allergy (2016)

In allergic asthma, environmental allergens including house dust mite (HDM) trigger pattern recognition receptors and activate downstream signaling pathways including NF-κB pathways not only in immune cells but also in airway epithelial cells. Recent studies have shown that NF-κB activation is regulated positively or negatively depending on the cellular context by IκBNS (encoded by the gene Nfkbid), one of atypical IκB proteins, in the nucleus. Therefore, we hypothesized that IκBNS expressed in immune cells or epithelial cells is involved in the regulation of asthmatic responses.To determine the roles of IκBNS in HDM-induced asthmatic responses.Roles of IκBNS in HDM-induced airway inflammation and airway hyper-responsiveness (AHR) were examined by using IκBNS-deficient (Nfkbid-/- ) mice. Roles of IκBNS expressed in hematopoietic cells and nonhematopoietic cells were separately evaluated by bone marrow chimeric mice. Roles of IκBNS expressed in murine tracheal epithelial cells (mTECs) were examined by air-liquid interface culture.House dust mite-induced airway inflammation and AHR were exacerbated in mice lacking IκBNS in hematopoietic cells. In contrast, HDM-induced airway inflammation was exacerbated, but AHR was attenuated in mice lacking IκBNS in nonhematopoietic cells. The induction of Muc5ac, a representative mucin in asthmatic airways, was reduced in Nfkbid-/- mTEC, whereas the induction of Spdef, a master regulator of goblet cell metaplasia, was not impaired in Nfkbid-/- mTEC. Moreover, IκBNS bound to and activated the MUC5AC distal promoter in epithelial cells.IκBNS is involved in inducing Muc5ac expression in lung epithelial cells and causing AHR in HDM-induced asthma models.
Hematopoietic Stem and Progenitor Cells in Patients with Mature B-Cell Malignancies Are Quantitatively and Qualitatively Deregulated Compared to Healthy Controls
Authors: Bokang Maswabi, Dana Prukova, Jan Molinsky, Magdalena Klanova, Lucie Lateckova, Petra Vockova, Tomas Zikmund, Filipp Savvulidi, Mahmudul Alam, Dana Vejmelkova, Radek Jaksa, Ludek Sefc, Martin Vokurka, Marek Trneny, Pavel Klener
Journal: Blood (2014)
Expression of serine protease inhibitors in epidermal keratinocytes is increased by calcium but not 1,25-dihydroxyvitamin D<sub>3</sub>or retinoic acid
Authors: M. Kobashi, S. Morizane, S. Sugimoto, S. Sugihara, K. Iwatsuki
Journal: British Journal of Dermatology (2017)

In human skin, the serine proteases kallikrein-related peptidase (KLK)5 and KLK7 degrade corneodesmosome proteins, leading to desquamation. Serine protease activity of the skin is tightly regulated by the interplay between such proteases and serine protease inhibitors, including lymphoepithelial Kazal-type related inhibitor (LEKTI), encoded by SPINK5; secretory leucocyte peptidase inhibitor (SLPI); and elafin. Expression of KLK5 and KLK7 is controlled and upregulated by stimulants such as calcium, 1,25-dihydroxyvitamin D3 [1,25(OH)2 VD3 ] and retinoic acid (RA).To understand the effect of calcium, 1,25(OH)2 VD3 and RA on the expression of serine protease inhibitors in epidermal keratinocytes.We stimulated normal human epidermal keratinocytes (NHEKs) with high calcium, 1,25(OH)2 VD3 or RA, and then analysed the expression of serine protease inhibitors using quantitative real-time polymerase chain reaction, enzyme-linked immunosorbent assay and immunocytofluorescence. We also analysed trypsin- and chymotrypsin-like serine protease activities in stimulated NHEKs.High calcium, but not 1,25(OH)2 VD3 or RA, significantly induced the expression of LEKTI, SLPI and elafin at both transcript and protein levels in NHEKs. These inductions were time- and dose-dependent. The activities of trypsin- and chymotrypsin-like serine proteases were significantly up- and downregulated by high calcium, respectively, in NHEKs.High calcium, but not 1,25(OH)2 VD3 or RA, increases the expression of serine protease inhibitors in epidermal keratinocytes. Our findings contribute to the understanding of the mechanisms by which serine protease activities are regulated by serine proteases and related inhibitors in epidermal keratinocytes.
Efficacy of high-dose leukocytaphereis using extracorporeal circulation through a large leukocyte-removal filter column in patients with refractory asthma
Authors: Tamotsu Ishizuka, Akio Koike, Motoaki Hatori, Shinichi Matsuzaki, Yosuke Kamide, Haruka Aoki, Takeshi Hisada, Hiroaki Tsurumaki, Akihiro Ono, Yasuhiko Koga, Kunio Dobashi, Kazuhiro Suzuki, Masatomo Mori
Journal: European Respiratory Journal (2011)

Leukocytapheresis (LCAP) as well as granulocyte and monocyte adsorptive apheresis (GMA) using extracorporeal circulation through the column has been used to treat inflammatory bowel disease and rheumatoid arthritis in Japan. We previously reported that GMA improved the peek expiratory flow rate (PEFR) in patients with severe asthma. To evaluate the efficacy of high-dose leukocytapheresis (pulse LCAP) using a large leukocyte-removal filter column (Cellsorba® CS-180S, Asahikasei Kuraray Medical, Tokyo, Japan) in patients with refractory asthma, we conducted a clinical trial. Pulse LCAP was performed 2 sessions at 1-week interval and 5 L of blood was filtered per session. The average PEFR during the 4 weeks just after the second LCAP in each patient was compared with that during the 4 weeks just before the first LCAP as a primary end point. The sum total of asthma control test (ACT) score at 4 weeks after the second LCAP was compared with that just before the first LCAP as a secondary end point. We evaluated the change of the fraction of exhaled nitric oxide (FENO) in each patient before and after pulse LCAP as a biomarker of eosinophilic airway inflammation. Five patients fulfilled the ATS criteria for refractory asthma participated in this trial up to now. The morning PEFR and the ACT score were increased in all patients. Although FENO was abnormally increased in four patients in spite of the standard therapy, it was decreased after pulse LCAP. Pulse LCAP might serve as a non-pharmacological strategy to induce clinical improvement in patients with refractory asthma through its unique anti-inflammatory effects.
Transfection of Bone Marrow Cells In Vitro or In Vivo Prior to Cryopreservation with Manganese Superoxide Dismutase (MnSOD-PL) Protects Frozen Cells from Ionizing Irradiation.
Authors: Michael W. Epperly, Laura D. Epperly, Darcy Franicola, Xicheng Zhang, Tracey Smith, Joel S. Greenberger
Journal: Blood (2006)
The IMPDH Inhibitor VX-944 Demonstrates In Vivo Efficacy in an Aggressive Leukemia Model.
Authors: Jugnu Jain, Jianguo Ma, Brinley Furey, Christian Recher, Cecile Demur, Srinivasu Poondru, Jianbo Zhang, Shaolan Li, Brant Firestone, Karen Olson, Maura Murphy, Jennifer Taylor, Greg Henkel, Edward Ball, Yung-Mae Yao, Susan Almquist, Russell Hoover
Journal: Blood (2004)
Effect of T Cell Recovery on Overall Survival (OS) Following Pentostatin Conditioning for Nonmyeloablative Allogeneic Stem Cell Transplantation (NST).
Authors: James E. Talmadge, Ugur Coskun, Sarah Maas, Orhan Turken, Ziviko S. Pavletic, Charles A. Kuszynski, Marcel Devetten, Laura R. Schafer, Lori Zobel, Robert G. Bociek
Journal: Blood (2007)
Do the Global Lung Function Initiative 2012 equations fit my population?
Authors: Philip H. Quanjer, Sanja Stanojevic
Journal: European Respiratory Journal (2016)

Knowing whether a patient's lung function result is similar to what can be expected of a healthy individual is critical for the correct interpretation of pulmonary function test results. Since lung function changes with growth and ageing and differs according to sex and ethnicity, there are now >300 published reference equations available for spirometry alone. Consequently, individual pulmonary function laboratories are left with a challenging decision: which reference equation do I choose? While it is recommended that reference equations are population specific, there are obvious logistical challenges to collect normative data from a large and representative population such that the resulting range of normal values are not biased. No reference equation applies universally: default equations should not be used without considering potential biases <http://ow.ly/29XB304sRrm>
Nonsteroidal Anti-Inflammatory Drugs, Alone or Combined With Opioids, for Cancer Pain
Authors: Ewan McNicol, Scott Strassels, Leonidas Goudas, Joseph Lau, Daniel Carr
Journal: Journal of Clinical Oncology (2004)

Purpose To assess the safety and efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs), alone or combined with opioids, for the treatment of cancer pain. Patients and Methods Forty-two trials involving 3,084 patients met inclusion criteria: eight compared NSAID with placebo; 13 compared one NSAID with another; 23 compared NSAID with opioid, NSAID or opioid versus NSAID plus opioid combinations, or NSAID plus opioid combinations versus NSAID plus opioid combinations; and nine studies assessed the effect of increasing NSAID dose. Results Sixteen studies lasted 1 week or longer and 11 evaluated a single dose. Seven of eight trials demonstrated superior efficacy of single doses of NSAID compared with placebo. Only four of 13 studies reported increased efficacy of one NSAID compared with another; four other studies found that one NSAID had fewer side effects than one or more others. Thirteen of 14 studies found no difference, or minimal clinical difference, when comparing an NSAID plus opioid combination versus either drug alone. Comparisons between various NSAID plus opioid combinations were inconclusive. Four studies demonstrated increased efficacy with increased NSAID dose, without dose-dependent increases in side effects. Conclusion Heterogeneity of study methods and outcomes precluded meta-analyses. Short duration of studies undermines generalization of findings on efficacy and safety. On the basis of limited data, NSAIDs appear to be more effective than placebo for cancer pain; clear evidence to support superior safety or efficacy of one NSAID compared with another is lacking; and trials of combinations of an NSAID with an opioid have disclosed either no significant difference, or at most a slight but statistically significant advantage, compared with either single entity.
Tandem Autologous Transplant Versus Reduced Intensity Conditioned Allogeneic Transplant (Allo-RIC) as Second Intensification in Chemosensitive Patients with Multiple Myeloma (MM) Not Achieving Complete Remission (CR) or Near-CR with a First Autologous Transplant. Results from a Spanish PETHEMA/GEM Study.
Authors: Joan Blade, Laura Rosinol, Juan Jose Lahuerta, Anna Sureda, Javier de la Rubia, Jose Garcia-Larana, Miguel Hernandez-Garcia, Belen Hernandez-Ruiz, Jose Antonio Perez-Simon, Jose Luis Bello, Dolores Carrera, Maria Jesus Penarrubia, Eugenia Abella, Angel Leon, Concepcion Poderos, Juan Carlos Garcia-Ruiz, Joan Besalduch, Rafael Martinez-Martinez, Isabel Perez-Fernandez, Paz Ribas, Jesus San Miguel
Journal: Blood (2007)
Psychotropic and Opioid Medication Use in Older Patients With Breast Cancer Across the Care Trajectory: A Population-Based Cohort Study
Authors: Ania Syrowatka, Sue-Ling Chang, Robyn Tamblyn, Nancy E. Mayo, Ari N. Meguerditchian
Journal: Journal of the National Comprehensive Cancer Network (2016)

Older patients with breast cancer represent a vulnerable population at higher risk of experiencing distress and pain, as well as medication-related adverse events from pharmacological treatment of these symptoms. The purpose of this study is to estimate the prevalence of psychotropic (anxiolytic, antidepressant, and antipsychotic) and opioid medication use by older women diagnosed with breast cancer.This population-based cohort study followed 19,353 women older than 65 years diagnosed with incident, nonmetastatic breast cancer in Quebec, Canada. Data were obtained from provincial, universal health and drug insurance plans covering all medical and pharmaceutical care. Descriptive statistics were calculated for demographic information, breast cancer characteristics, and treatments. Psychotropic and opioid medication use was assessed across the care trajectory: precancer baseline, active care, and first-year survivorship.There was a marked increase in the prevalence of medication use from precancer baseline to active care, followed by a decrease into first-year survivorship. Anxiolytics were used most often across the care trajectory (36.3%, 50.6%, and 44.4% at baseline, active care, and survivorship, respectively). In contrast, antipsychotic and opioid medications were sought primarily during active care (4.5- and 7-fold increases from baseline, respectively), with opioid use during active care increasing dramatically over the study period (9.0% to 40.9% from 1998 to 2010). Unlike other drugs, antidepressant use peaked in active care but persisted into survivorship (14.7%, 22.4%, and 22.3% at baseline, active care, and survivorship, respectively).A substantial proportion of older patients with breast cancer use psychotropic and opioid medications. The different patterns of medication use represent distress and pain experienced by patients across the care trajectory. Given that medication use in this vulnerable population is associated with an increased risk of adverse events, a multidimensional approach integrating psychological interventions in cancer care may better address psychosocial needs of older patients with breast cancer.
Development and Validation of a Predictive Model for Death in Acquired Severe ADAMTS13 Deficiency-Associated Idiopathic Thrombotic Thrombocytopenic Purpura: The French TMA Reference Center Experience
Authors: Ygal Benhamou, Cyrielle Assie, Pierre-Yves Boelle, Marc Buffer, Rana Grillberger, Sandrine Malot, Dominique Bordessoule, Lionel Galicier, Elie Azoulay, Hanspeter Rottensteiner, Agnes Veyradier, Paul Coppo
Journal: Blood (2011)
Detection of Renal Impairment (RI) as One Specific Comorbidity Factor in Multiple Myeloma (MM) Patients: Multi-Center Study in 198 Consecutive Patients
Authors: Martina Kleber, Gabriele Ihorst, Barbara Deschler, Christian Jakob, Peter Liebisch, Bernd Koch, Orhan Sezer, Monika Engelhardt
Journal: Blood (2008)
Pure Red Cell Aplasia (PRCA) in Chronic Lymphocytic Leukemia (CLL): Etiology, Therapy, and Outcomes
Authors: Mazie Tsang, Kari Rabe Chaffee, Timothy G. Call, Wei Ding, Jose F. Leis, Asher Chanan-Khan, Michael Conte, Deborah A. Bowen, Susan M. Schwager, Susan L. Slager, Neil E. Kay, Tait D. Shanafelt, Sameer A. Parikh
Journal: Blood (2015)
Sofosbuvir With Velpatasvir in Treatment-Naive Noncirrhotic Patients With Genotype 1 to 6 Hepatitis C Virus Infection
Authors: Gregory T. Everson, William J. Towner, Mitchell N. Davis, David L. Wyles, Ronald G. Nahass, Paul J. Thuluvath, Kyle Etzkorn, Federico Hinestrosa, Myron Tong, Mordechai Rabinovitz, John McNally, Diana M. Brainard, Lingling Han, Brian Doehle, John G. McHutchison, Timothy Morgan, Raymond T. Chung, Tram T. Tran
Journal: Annals of Internal Medicine (2015)

Pangenotypic treatments for HCV infection would be useful worldwide. In a phase 2 trial, treatment with sofosbuvir plus velpatasvir resulted in high sustained virologic response at 12 weeks in pati...
The Burden of Fatigue and Quality of Life in Myeloproliferative Disorders (MPDs): An International Internet Based Survey of 1179 MPD Patients.
Authors: Ruben A. Mesa, Joyce Niblack, Martha Wadleigh, D.G. Gilliland, Srdan Verstovsek, Hagop Kantarjian, John Camoriano, Lawrence Solberg, Sunni Barnes, Angelina Tan, Pamela Atherton, Jeffrey Sloan, Ayalew Tefferi
Journal: Blood (2006)
Antiproliferative Effect of 2-Hydroxypropyl-β-Cyclodextrin (HP-β-CyD) Against Chronic Myeloid Leukemia In Vitro and In Vivo.
Authors: Masako Yokoo, Yasushi Kubota, Sakiko Mochinaga, Aya Maeda, Tatsuo Ichinohe, Hiroshi Fujito, Taishi Higashi, Keiichi Motoyama, Hidetoshi Arima, Tetsumi Irie, Shinya Kimura
Journal: Blood (2012)
BCR/ABL Dosage Hierarchically and Temporally Influences hnRNP A1, hnRNP K and hnRNP E2 Expression in Hematopoietic Stem and Progenitor Cells.
Authors: Jason Harb, Paolo Neviani, Claudia Huettner, Guido Marcucci, Danilo Perrotti
Journal: Blood (2009)
Unusual Presentations of Thoracic Tumors
Authors: Yuki Nanke, Hideto Akama, Akira Hebisawa, Mayumi Suzuki, Shinobu Akagawa, Mutsuto Tateishi, Hajime Yamagata, Toshiaki Kawai, Naoyuki Kamatani
Journal: Journal of Clinical Oncology (2001)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.17.3782 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11533103 Unusual Presentations of Thoracic Tumors Case 2. Malignant Mesothelioma Mimicking Rheumatoid Pleurisy Yuki NankexYuki NankeSearch for articles by this author , Hideto AkamaxHideto AkamaSearch for articles by this author , Akira HebisawaxAkira HebisawaSearch for articles by this author , Mayumi SuzukixMayumi SuzukiSearch for articles by this author , Shinobu AkagawaxShinobu AkagawaSearch for articles by this author , Mutsuto TateishixMutsuto TateishiSearch for articles by this author , Hajime YamagataxHajime YamagataSearch for articles by this author , Toshiaki KawaixToshiaki KawaiSearch for articles by this author , Naoyuki KamatanixNaoyuki KamataniSearch for articles by this author Show More Tokyo Women’s Medical University, National Murayama Hospital, National Tokyo Hospital, and National Defense Medical College, Japan https://doi.org/10.1200/JCO.2001.19.17.3782 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology