Chronic Hepatitis and Non-Hodgkin Lymphoma Among People With HIV: Implications for Screening, Treatment, and Prevention
Authors: Charles S. Rabkin, James J. Goedert
Journal: Annals of Internal Medicine (2016)

Editorials3 January 2017Chronic Hepatitis and Non-Hodgkin Lymphoma Among People With HIV: Implications for Screening, Treatment, and PreventionCharles S. Rabkin, MD and James J. Goedert, MDCharles S. Rabkin, MDFrom National Cancer Institute, Bethesda, Maryland.Search for more papers by this author and James J. Goedert, MDFrom National Cancer Institute, Bethesda, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-2340 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail People living with HIV (PLWH) have a high risk for lymphoma, particularly non-Hodgkin lymphoma (NHL) and Hodgkin lymphoma. The likelihood of developing NHL with severe immunosuppression is approximately 1% annually, an increase of about 100-fold compared with the general population. Even with a stable, effective antiretroviral therapy (ART) regimen, PLWH have a roughly 10-fold higher NHL risk than the general population. Non-Hodgkin lymphoma is now a leading cause of death for PLWH (1). Thus, identifying NHL-specific risk factors and interventions is a high priority for improving HIV/AIDS clinical care.A team of investigators from the Collaboration of Observational HIV Epidemiological ...References1. Griffin DO, Metzger M, Poeth K, Deng K, Dharsee A, Rico JC, et al. Malignancies, particularly B-cell lymphomas, are a frequent cause of mortality in human immunodeficiency virus-1 patients despite highly active antiretroviral therapy. Open Forum Infect Dis. 2015;2:ofv147. [PMID: 26566539] doi:10.1093/ofid/ofv147 CrossrefMedlineGoogle Scholar2. 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[PMID: 17106439] CrossrefMedlineGoogle Scholar8. Waters L, Stebbing J, Mandalia S, Young AM, Nelson M, Gazzard B, et al. Hepatitis C infection is not associated with systemic HIV-associated non-Hodgkin's lymphoma: a cohort study. Int J Cancer. 2005;116:161-3. [PMID: 15756687] CrossrefMedlineGoogle Scholar9. Jou E, Gligich O, Chan AC, Mohan D, Felsen UR, Ayyappan S, et al. Viral co-infections and paraproteins in HIV: effect on development of hematological malignancies. Ann Hematol. 2016;95:575-80. [PMID: 26747296] doi:10.1007/s00277-016-2588-z CrossrefMedlineGoogle Scholar10. Goedert JJ, Hosgood HD, Biggar RJ, Strickler HD, Rabkin CS. Screening for cancer in persons living with HIV infection. Trends in Cancer. 2016;2:416-28. doi:10.1016/j.trecan.2016.06.007 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From National Cancer Institute, Bethesda, Maryland.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-2340.Corresponding Author: Charles S. Rabkin, MD, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892.Current Author Addresses: Drs. Rabkin and Goedert: Division of Cancer Epidemiology and Genetics, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892.This article was published at www.annals.org on 18 October 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoChronic Hepatitis B and C Virus Infection and Risk for Non-Hodgkin Lymphoma in HIV-Infected Patients Qing Wang , Andrea De Luca , Colette Smith , Robert Zangerle , Helen Sambatakou , Fabrice Bonnet , Colette Smit , Philipp Schommers , Alicia Thornton , Juan Berenguer , Lars Peters , Vincenzo Spagnuolo , Adriana Ammassari , Andrea Antinori , Eugenia Quiros Roldan , Cristina Mussini , Jose M. Miro , Deborah Konopnicki , Jan Fehr , Maria A. Campbell , Monique Termote , Heiner C. Bucher , and Metrics 3 January 2017Volume 166, Issue 1Page: 69-70KeywordsAntiretroviral therapyCancer epidemiologyCancer geneticsHIVHIV epidemiologyHazard ratioHepatitis CHodgkin lymphomaLymphomaMolecular epidemiology ePublished: 18 October 2016 Issue Published: 3 January 2017 PDF downloadLoading ...