tbuckley/cabot-search huggingface dataset:
Impact of Virtual MRI Sonography with Magnetic Navigation on Detecting Residual Tumors in Patients with Breast Cancer Who Undergo Neoadjuvant Chemotherapy; Initial Experience.
Authors: S. Nakano, K. Fujii, K. Yorozuya, M. Yoshida, Y. Mouri, J. Kousaka, T. Fukutomi, J. Kimura, T. Ishiguchi
Journal: Cancer Research (2009)

Abstract Objective: The accurate evaluation of the extent of residual disease after neoadjuvant chemotherapy (NAC) for breast cancer appears essential for successful clinical outcomes. However, there are limited date about the success of achieving negative margins in breast conservation therapy. Recently, we have developed virtual MRI sonography with magnetic navigation (real-time virtual sonography; RVS). RVS can overlay high-resolution structural image taken by sonography with functional image reflecting vascular permeability taken by MRI of the same site in real time. The objective of our study was to determine the relative accuracy of RVS in detecting residual tumors after NAC.Materials and Methods: Between April 2007 and May 2009, 96 breast conservation therapy were performed for invasive ductal carcinoma at our hospital. Fourteen patients with stage IIA-IIIB palpable invasive ductal carcinoma were enrolled in a study investigating the effects of NAC on tumor imaging. All patients underwent mammography, sonography, MRI, and RVS before and after NAC. MRI was performed with a 1.5-T scanner in the supine position using a flexible body surface coil to achieve the same position as that used in sonography. Based on MRI results, the absence or presence of residual tumors was used to classify treatment response into a clinically complete response (cCR) or non-cCR, respectively. Nine patients received lumpectomy, and 5 received mastectomy. The surgical resection area was determined by RVS. Detection rate was determined for residual tumors with or without RVS. The pathologically complete response (pCR) was defined as no invasive carcinoma.Results: All index tumors were detected by sonography and MRI before NAC. After NAC, a cCR was seen in 5 (5 of 14, 36%) patients. MRI correctly diagnosed pCR in 4 (4 of 5, 80%) patients. Detection rate for residual tumors was 9% (1 of 11) for mammography, 33% (3 of 9) for sonography alone, 78% (7 of 9) for MRI, and 89% (8 of 9) for RVS. It was noteworthy that 5 (5 of 5, 100%) cases with cCR were accurately localized onto the body surface with supplementation using RVS combined with pre- and post-NAC imaging while we were checking sonography. Although surgical excision was incomplete in 5 (5 of 9, 56%) patients, all positive surgical margins were ductal carcinoma in situ.Conclusions: By using RVS, two different forms of diagnostic imaging can be integrated in real time and thereby complement each other. The present results suggest that RVS is a useful imaging technique for detecting residual tumors that have been associated with local recurrence after NAC. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5024.
CPRE Y SEDACIÓN CON PROPOFOL EN UN HOSPITAL TERCIARIO
Authors: L Ollero, L Luzon, R Uribarrena, J Val, E Sierra
Journal: Endoscopy (2014)

Introducción: la administración de propofol por el endoscopista en exploraciones endoscópicas complejas permite un nivel de sedación óptimo con una baja incidencia de complicaciones.
Genetic Defects of Griscelli Syndrome Type 2 in Saudi Arabia
Authors: H. Al-Mousa, A. Al-Ghonaium, H. Al-Dhekri, S. Al-Muhsen, B. Al-Saud, R. Arnaout, N. Ades, S. Alhisi, A. Hawwari
Journal: Journal of Allergy and Clinical Immunology (2012)
A6.31 Contributions of canonical and non-canonical NF-κB signalling to LTR-driven inflammatory activation of endothelium and interaction with leukocytes
Authors: P Kucharzewska, CX Maracle, H Olsson, SW Tas
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Sites of chronic inflammation, such as rheumatoid arthritis synovial tissue, are often characterised by the formation of tertiary lymphoid structures, which show characteristic features of lymphoid organs, like high endothelial venules (HEV) and sometimes even true germinal centres. Ligation of the lymphotoxin (LT)-β receptor (LTβR) results in activation of both canonical and non-canonical NF-κB signalling in endothelial cells (ECs) and plays a crucial role in lymphoid neogenesis. Non-canonical NF-κB signalling in ECs promotes inflammation-induced angiogenesis and triggers the development of the cuboidal HEV appearance. However, the relative contribution of the individual pathways to the acquisition of leukocyte traffic-regulating properties by ECs is less well understood. We therefore aimed to identify the molecular pathways by which LTβR drives activation of ECs and interactions with leukocytes. <h3>Methods</h3> Primary human ECs were stimulated with LTβ or LIGHT to activate LTβR. Activation of downstream signalling pathways was assessed by western blot analysis. Levels of cytokines secreted by LTβ-treated ECs were measured in conditioned media using antibody arrays. To block canonical NF-κB signalling pathway, a small molecule inhibitor of IKKβ was used. Inactivation of non-canonical NF-κB signalling was obtained with a small molecule inhibitor of NIK, and siRNAs targeting NIK or NFκB2. EC interactions with leukocytes were determined by an adhesion assay, whereas EC monolayer permeability was assessed by a permeability assay. <h3>Results</h3> Treatment of ECs with LTβ or LIGHT activated both canonical and non-canonical NF-κB signalling pathways. Exposure of ECs to LTβ induced the expression of several inflammatory cytokines (IL-8, IL-6, CXCL1, CXCL5, MCP-1, GM-CSF, MIP3α), and this response was mediated mainly by the canonical NF-κB pathway. Consistent with the inflammatory activation of ECs, LTβR ligation induced adhesion of T cells and monocytes to activated endothelium in a predominantly canonical NF-κB-dependent manner. Of note, LTβ was more potent at inducing adhesive properties of ECs than LIGHT. Finally, LTβR ligation by LTβ induced permeability across EC monolayers. <h3>Conclusions</h3> LTβR ligation on ECs drives inflammation-induced angiogenesis and differentiation into HEV via the non-canonical NF-κB pathway, as well as inflammatory activation of the endothelium and leukocyte adhesion through canonical NF-κB signalling, implicating ECs as immune cell mobilizers during the formation of tertiary lymphoid structures in the course of autoimmune diseases. Further molecular dissection of these pathways may help to better understand the function of tertiary lymphoid structures and potentially to develop therapeutics that modulate the formation of these structures and reduce inflammation.
Assessment of the Risk of the Respiratory-Distress Syndrome by a Rapid Test for Surfactant in Amniotic Fluid
Authors: John A. Clements, Arnold C. G. Platzker, Donald F. Tierney, Calvin J. Hobel, Robert K. Creasy, Alan J. Margolis, Donald W. Thibeault, William H. Tooley, William Oh
Journal: New England Journal of Medicine (1972)

A rapid, simple inexpensive test has been devised to determine whether pulmonary surface-active material (surfactant) is present in amniotic fluid. The test depends on the ability of the pulmonary surfactant to generate stable foam in the presence of ethanol. Analysis of 138 samples of amniotic fluid showed that an appreciable titer of the surfactant appears on the average at 33 weeks' estimated gestation but that the time of appearance is variable from 25 weeks to term. When test results were sorted into three zones (clearly negative, intermediate, and clearly positive) infants of 12 of 12 patients with clearly negative tests had severe respiratory-distress syndrome or transitional respiratory distress, whereas those of 68 of 68 patients with clearly positive tests were free of respiratory distress. In 13 cases with intermediate tests eight of the infants showed mild to severe respiratory difficulty. The test has high predictive value for respiratory-distress syndrome when applied to uncontaminated amniotic fluid.
Abstract 1710: An anti-apoptotic Bcl-2 family protein index predicts the response of leukemic cells to the pan-Bcl-2 inhibitor S1.
Authors: Yubo Liu, Zhichao Zhang
Journal: Cancer Research (2013)

Abstract Bcl-2-like proteins prevent cell death through expression level, post transcriptional modification, and protein-protein-interaction. Recent studies have shown that antiapoptotic Bcl-2-like members are overexpressed in many haematological malignancies. BH3 mimetics are promising anticancer agents by directly target these proteins and their interactions. S1 (8-oxo-3-thiomorpholin-4-yl-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile) is an authentic BH3 mimetic and a triple inhibitor of Bcl-2, Mcl-1, and Bcl-XL. In the present study, we found S1 exhibited a variant sensitivity with LD50 values ranging &amp;gt;2 logs (0.24-80.4 μM) in five established leukemia cell lines (Jurkat, K562, HL60, U937 and PTA-3920) and forty-one primary leukemic cells (including Acute myeloid leukemia (AML), Acute lymphoblastic leukemia (ALL), Chronic Myeloid Leukemia (CML), and Chronic lymphoblastic leukemia (CLL)). Through a semi-quantitative approach by analyzing western blotting bands via imaging software, it revealed that the index value phosphoralated Bcl-2 (pBcl-2) to Bcl-2 and Mcl-1 provided a highly significant linear correlation with S1 sensitivity (r = 0.69, P &amp;lt; 0.001 in primary cells, and r = 0.76, P = 0.05 in cell lines). In contrast, antiapoptotic Bcl-2-like protein levels, used individually or in combination could not predict S1 sensitivity. Phosphorylated Bcl-2 antagonized S1 by sequestering the Bak and Bim proteins that were released from Mcl-1 in leukemia cell lines. Furthermore, pBcl-2/Bak, pBcl-2/Bax, and pBcl-2/Bim complexes cannot be disrupted by S1. The shift of proapoptotic proteins from being complexed with Mcl-1 to being complexed with pBcl-2 is revealed for the first time, and it could be the mechanism underlying the index value described herein. This study defines the antiapoptotic role of pBcl-2 linked with the protein-protein interaction network within Bcl-2 family. Citation Format: Yubo Liu, Zhichao Zhang. An anti-apoptotic Bcl-2 family protein index predicts the response of leukemic cells to the pan-Bcl-2 inhibitor S1. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1710. doi:10.1158/1538-7445.AM2013-1710 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
HIGH ADOPTION RATES OF MOBILE TECHNOLOGY BY CARDIOLOGY CLINIC PATIENTS BUT LIMITED USE OF HEALTH APPLICATIONS
Authors: Javier E. Banchs, Victor Benvenuto, Giselle A. Baquero, Stacy L. Hess, Kristin E. Heron, Stacey LaPine, Michelle Nickolaus, Jason Fragin, Douglas Leslie, William J. Curry
Journal: Journal of the American College of Cardiology (2014)
AB1210 Aspects of temporomandibular joint arthritis-related orofacial symptoms in juvenile idiopathic arthritis
Authors: P. Stoustrup, K.D. Kristensen, A. Küseler, T.K. Pedersen, T. Herlin
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Temporomandibular joint (TMJ) inflammation in patients with juvenile idiopathic arthritis (JIA) may interfere with optimal joint and muscular function. Orofacial symptoms are common clinical findings in relation to TMJ arthritis in adolescence. Knowledge about their clinical manifestation is important for TMJ arthritis diagnosis, treatment choice and outcome evaluation. <h3>Objectives</h3> The aim of this prospective study was to evaluate and describe the frequency, the main complaints and the localisation of TMJ arthritis-related orofacial symptoms. Additionally, the smallest detectable differences for minimal, average and maximal pain were estimated. <h3>Methods</h3> Thirty-three patients with JIA and arthritis-related orofacial symptoms in relation to 55 affected TMJs were included in the present questionnaire study (mean age 14.11 years). All patient were asked to fill out an examination-questionnaire concerning: duration, frequency, localisation and characterise their orofacial pain. Duplicate visual analogue scale (VAS) assessments concerning average, maximal and minimal orofacial pain-intensity were carried out 45 minutes apart. <h3>Results</h3> The majority of the patients were girls (31/34, 94%). Orofacial symptoms were seen most often during mastication and maximal mouth opening procedures. Persistent orofacial symptoms were rare. The TMJ area in combination with the masseter muscle region was the orofacial region where symptoms were most common. The smallest detectable differences for minimal, average and maximal pain were between 11 and 14 mm on a VAS. <h3>Conclusions</h3> This study offers new knowledge about TMJ arthritis-related orofacial symptoms that may aid diagnosis and clinical decision-making. The findings also allow us to suggest that TMJ arthritis-related orofacial symptoms should be understood as a product of the primary TMJ inflammation in combination with secondary myogenic and functional issues. <h3>Disclosure of Interest</h3> None Declared
Abstract 1183: Association of germline variants of the <i>TGFβR1</i> gene in colorectal cancer patients
Authors: James P. Schaeper, Kevin Murray, Jessica L. DeBrosse, Briana Vogt, Denise Lucas, Bruce M. Colligan, James A. Deddens, Larry E. Douglass, Jeremy R. Graff, Julia H. Carter
Journal: Cancer Research (2010)

Abstract Colorectal cancer is the second leading cause of cancer death in the United States and approximately 147,000 new cases of colorectal cancer (CRC) were expected in 2009. Most people with early colorectal cancer have no symptoms and symptoms usually only appear with more advanced disease. Therefore, susceptibility markers which could possibly identify patients at risk for colorectal cancer are important for earlier detection of the disease. Germline variations in the transforming growth factor beta (TGF-β) type I receptor (TGFβR1) have been found to be associated with several human cancers, in particular with advanced ovarian cancers, suggesting a role in advanced disease stage. We analyzed two genetic variants in the TGFβR1 gene for their association with colorectal cancer. One is an intronic variant, G→A polymorphism (Int7G24A), which is 24 base pairs downstream of the intron-exon 7 boundary. The other is a nine base pair deletion (TGFβR1*6A) in exon 1 of TGFβR1. Using capillary electrophoresis, we analyzed paraffin-embedded tissue specimens from 147 patients with CRC and 169 non-cancer controls. There was no difference between male and female non-cancer controls in the prevalence of either variant. When CRC cases were compared to non-cancer controls, it was found that the prevalence of TGFβR1*6A was not significantly increased (p = 0.11) but Int7G24A prevalence was significantly increased (p = 0.000039). For CRC cases and controls, the wild type genotype was compared to patients with either or both variants and a significant difference was found primarily due to the increased prevalence of Int7G24A in CRC patients (p = 0.000052). Int7G24A was more commonly found in invasive and metastatic CRC patients as compared to non-cancer controls (p = 0.00030). We conclude that Int7G24A is a potential susceptibility marker for CRC and is associated with advanced disease stage. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1183.
Impairment of Renal Function with Increasing Blood Lead Concentrations in the General Population
Authors: Jan A. Staessen, Robert R. Lauwerys, Jean-Pierre Buchet, Christopher J. Bulpitt, Désiré Rondia, Yves Vanrenterghem, Antoon Amery
Journal: New England Journal of Medicine (1992)

Nephropathy is known to occur in persons with heavy exposure to lead. Whether exposure to lead in the general population leads to impaired renal function is not known.We studied renal function and indexes of lead exposure in a random population sample of 965 men and 1016 women (age range, 20 to 88 years). In all the subjects we measured creatinine clearance and blood concentrations of lead and zinc protoporphyrin (an indirect measure of blood lead level).The mean (+/- SD) creatinine clearance rate was 99 +/- 30 ml per minute in the men and 80 +/- 25 ml per minute in the women. In the men the geometric mean blood lead concentration was 114 micrograms per liter (0.55 mumol per liter) (range, 23 to 725 micrograms per liter [0.11 to 3.5 mumol per liter]), and in the women 75 micrograms per liter (0.36 mumol per liter) (range, 17 to 603 micrograms per liter [0.08 to 2.9 mumol per liter]); the zinc protoporphyrin values in blood averaged 1.0 and 1.1 micrograms per gram of hemoglobin, respectively. The creatinine clearance rate was inversely correlated with blood lead and zinc protoporphyrin values in the men and the women both before and after adjustments for age, bodymass index, and diuretic treatment. A 10-fold increase in blood lead concentration was associated with a reduction of 10 to 13 ml per minute in creatinine clearance. We also found a positive correlation between serum beta 2-microglobulin (which is inversely related to the glomerular filtration rate) and blood lead in men, between serum beta 2-microglobulin and zinc protoporphyrin in both sexes, and between serum creatinine and zinc protoporphyrin in men.Exposure to lead may impair renal function in the general population. The alternative hypothesis that renal impairment may lead to an increase in the blood lead concentration cannot be excluded, however.
Disadvantaged families are at greatest risk from austerity cuts to children’s centres
Authors: James Hall, Pam Sammons, Kathy Sylva, Maria Evangelou, Naomi Eisenstadt, Teresa Smith, George Smith
Journal: BMJ (2016)

As authors of the research outlined in your report we were pleased by The BMJ ’s coverage of our findings on children’s centres.1 However, we also showed that the threat posed by austerity cuts was even greater in the 20% most financially disadvantaged …
Multiple Primary Hepatic Malignant Mesotheliomas Mimicking Cystadenocarcinomas on Enhanced CT and FDG PET/CT
Authors: Aisheng Dong, Hui Dong, Changjing Zuo
Journal: Clinical Nuclear Medicine (2013)

A 50-year-old woman presented with upper abdominal pain for 2 months. Abdominal enhanced CT showed multiple hypodense cystic tumors in the liver with heterogeneous enhanced septations. FDG PET/CT showed hypermetabolic peripheral regions and internal septations of the tumors with SUVmax of 6.3. Multiple hepatic cystadenocarcinomas were suspected. The patient underwent resection of the tumors. Epithelial mesothelioma was confirmed by pathology. This case indicates primary hepatic mesothelioma should be added to the differential diagnosis of FDG-avid malignant hepatic tumors.
Endoscopic treatment of an infected retroperitoneal hematoma following endoscopic ultrasound-guided pseudocyst drainage
Authors: Ilaria Tarantino, Luca Barresi, Antonino Granata, Neville Azzopardi, Gabriele Curcio, Mario Traina
Journal: Endoscopy (2013)

A 32-year-old man with alcoholic pancreatitis presented with the complaint of abdominal pain and vomiting that necessitated parenteral feeding. Abdominal computed tomography (CT) scan showed a 10-cm pseudocyst in the pancreatic body ([Fig. 1]) [1]. In view of persisting symptoms and the pseudocyst size, he was referred for endoscopic ultrasound (EUS)-guided cystogastrostomy.
Abstract 3455: Arsenic trioxide modulates DNA synthesis and apoptosis in lung carcinoma cells
Authors: Alice M. Walker, Jacqueline J. Stevens, Paul B. Tchounwou
Journal: Cancer Research (2010)

Abstract Arsenic trioxide, the trade name Trisenox, is a drug used to treat acute promyleocytic leukemia (APL). Studies have demonstrated that arsenic trioxide slows the cancer cells growth. Although it has been reported that arsenic acts on cells by influencing numerous signal transduction pathways, cell cycle progression, and/or apoptosis, its apoptotic mechanisms are very complex. The primary objective of this research is to evaluate the effects of arsenic trioxide on DNA synthesis and to determine whether arsenic induced-apoptosis is mediated via caspase activation, p38 mitogen-activated protein kinase (MAPK), and cell cycle arrest. To achieve this goal, the lung cancer (A549) cells were cultured following standard protocol, and exposed to various doses (0, 2, 4, and 6 µg/ml) of arsenic trioxide for 48 h. The effect of arsenic trioxide on DNA synthesis was determined by [3H]thymidine incorporation assay. Apoptosis was determined by caspase-3 fluorescein isothiocyanate (FITC) assay, and immunoblot analysis (p38 MAP kinase activity). The cell cycle analysis was evaluated propidium iodide assay. [3H]Thymidine incorporation assay revealed dose-related cytotoxic response at higher levels of exposure. Our findings revealed that arsenic trioxide modulated caspase 3 activity and induced p38 map kinase activation in lung carcinoma (A549) cells. The data revealed no cell cycle arrest at the sub-G0 in A549 cells when treated with arsenic trioxide. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3455.
A Randomized, Controlled Trial of a Behavioral Intervention to Prevent Sexually Transmitted Disease among Minority Women
Authors: Rochelle N. Shain, Jeanna M. Piper, Edward R. Newton, Sondra T. Perdue, Reyes Ramos, Jane Dimmitt Champion, Fernando A. Guerra
Journal: New England Journal of Medicine (1999)

African-American and Hispanic women are disproportionately affected by sexually transmitted diseases, including the acquired immunodeficiency syndrome (AIDS). In the effort to reduce infection rates, it is important to create and evaluate behavioral interventions that are specific to the target populations.
Evidence, Policy, and E-Cigarettes — Will England Reframe the Debate?
Authors: Sharon H. Green, Ronald Bayer, Amy L. Fairchild
Journal: New England Journal of Medicine (2016)

Public Health England claims that e-cigarettes are 95% less harmful than combustible cigarettes and suggests that they can help reduce health inequalities. But the United Kingdom's long-standing commitment to harm reduction contrasts dramatically with the U.S. position.
VALIDATION OF THE ATHEROSCLEROTIC CARDIOVASCULAR DISEASE (ASCVD) POOLED COHORT RISK EQUATIONS BY EDUCATION LEVEL: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
Authors: Kamal Hanee Henderson, Brystana G. Kaufman, Sally Stearns, David Couper, Carla Sueta, Anna M. Kucharska-Newton, Randi E. Foraker, Josephine Asafu-Adjei, Patricia Chang
Journal: Journal of the American College of Cardiology (2016)