AB0676 Neutrophil Lymphocyte Ratio Can be a Valuable Marker in Defining Disease Activity in Patients with As
Authors: Y. Pehlivan, B.N. ÇOskun, M.F. Öksüz, E. Dalkılıç, A.N. Tufan
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Erythrocyte sedimentation rate (ESR) and serum C reactive protein (CRP) are two common tools for indicating systemic inflammatory disease such as ankylosing spondylitis (AS). Recently, neutrophil lymphocyte ratio (NLR) has emerged as an easy and reliable method for this purpose in several inflammatory disease. In this study we aimed to evaluate the role of NLR for indicating inflammation and also to compare its relation with other measures such as ESR, CRP and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). <h3>Objectives</h3> In this study we aimed to evaluate the role of NLR for indicating inflammation and also to compare its relation with other measures such as ESR, CRP and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). <h3>Methods</h3> A total of 35 patients who had a full dose of non-steroid anti-inflammatory drugs (NSAIDs) at least three months and a BASDAI score above 4 or active sacroileitis and a total of 38 healthy volunteers were included in the study. The patients9 charts were investigated retrospectively. The patient group was enrolled for treatment with one of anti-Tumor Necrosis Factor (TNF) drugs. Total blood count, ESR, CRP, BASDAI score were obtained before and three months following the treatment. NLR was found with a mathematical calculation of ratio of neutrophils with lymphocytes. <h3>Results</h3> The mean NLR value of the control group and patients was 1.90±0.89 and 2.67±1.17 respectively (p&lt;0.05). After a 3 months course of treatment the patient group had a mean NLR value of 1.8±0.7 which was significantly lower than pretreatment values (p&lt;0.001). The post treatment mean ESR, CRP and BASDAI scores were significantly lower than mean baseline scores (p&lt;0.001, p: 0.007, p ..., respectively). Also, NLR was found to be correlated with BASDAI, ESR and CRP (r=0.388, p&lt;0.001; r=0.455, p&lt;0.0001 and r=0.3389, p&lt;0.005 respectively). <h3>Conclusions</h3> NLR could be reliable and easily accessible method for follow up of patients with AS <h3>References</h3> Forget P, Machiels JP, Coulie PG, Berliere M, Poncelet AJ, Tombal B, Stainier A, Legrand C, Canon JL, Kremer Y, De Kock M Lee DY, Hong SW, Chang YG, Lee WY, Lee B Azab B, Jaglall N, Atallah JP, Lamet A, Raja-Surya V, Farah B, Lesser M, Widmann WD Markar SR, Karthikesalingam A, Falzon A, Kan Y Solak Y, Yilmaz MI, Sonmez A, Saglam M, Cakir E, Unal HU, Gok M, Caglar K, Oguz Y, Yenicesu M, Karaman M, Ay SA, Gaipov A, Turk S, Vural A, Carrero JJ Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ Ahsen A, Ulu MS, Yuksel S, Demir K, Uysal M, Erdogan M, Acarturk G Öztürk ZA, Yesil Y, Kuyumcu ME, Bilici M, Öztürk N, Yeşil NK, Özkaya M, Kısacık B, Kepekçi Y, Arıoğul S Weyrich AS, Lindemann S, Zimmerman GA. The evolving role of platelets in inflammation. Journal of Thrombosis and Haemostasis 2003. 1: 1897–1905. Martin JF, Shaw T, Heggie J, Penington DG. Measurement of the density of human platelets and its relationship to volume. British Journal of Haematology 1983. 54: 337–352. Soydinc S, Turkbeyler IH, Pehlivan Y, Soylu G, Goktepe MF, Bilici M, Zengin O, Kisacik B, Onat AM. Mean Platelet Volume Seems To Be a Valuable Marker in Patients with Systemic Sclerosis. Inflammation. 2013 Sep 1. Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdogan A, Ozturk MA, Kiraz S, Ertenli I, Calguneri M. Mean platelet volume (MPV) as an inflammatory marker in ankylosing spondylitis and rheumatoid arthritis. Joint Bone Spine. 2008 May;75(3):291-4. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4303