tbuckley/cabot-search huggingface dataset:
Abstract 3243: DIM inhibits growth of human gastric cancer through modulation of the hippo signaling pathway.
Authors: Xiu Juan Li, Hwan Hee Lee, Soo Mi Kim
Journal: Cancer Research (2013)

Abstract 3, 3-diindolylmethane (DIM) has been reported that it has anti-proliferative effects in many cancer cells. However, the biological functions of DIM in human gastric cancer cells are unknown. Genetic and biological studies have confirmed the importance of the novel hippo tumor suppressor pathway in regulating cell proliferation, apoptosis, organ size, and tumorigenesis in mammals. Thus, the purpose of this study was to investigate the cytotoxic effects of DIM in human gastric cancer cells and to elucidate whether DIM induces cell death by activating the hippo signaling pathway. Four human gastric cancer cell lines (SNU1, SNU16, SNU484, and SNU638) were used to test the response of DIM. MTT, cell cycle and western blot analyses were conducted. DIM significantly inhibited the proliferation of human gastric cancer cells in a dose-dependent manner. The percentage of G1 phase cells increased 24h after being treated by DIM. DIM reduced CDK2, CDK4, CDK6, CyclinD1 protein levels and increased p53 protein levels. DIM also induced cleaved poly (ADP-ribose) polymerase, cleaved-caspase-9 levels, and diminished pro-caspase-3 protein expression levels. Additionally, DIM increased P-LATS1, Mob1, P-Mob1, P-Yap protein levels and reduced Yap protein levels. Moreover, DIM inhibited the growth of human esophageal tumors in an orthotopic mouse model. These results suggest that DIM can sensitize gastric cancers by modulating the hippo signaling pathway linked to tumorigenesis. Citation Format: Xiu Juan Li, Hwan Hee Lee, Soo Mi Kim. DIM inhibits growth of human gastric cancer through modulation of the hippo signaling pathway. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3243. doi:10.1158/1538-7445.AM2013-3243 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Regression of esophageal varices during entecavir treatment in patients with hepatitis-B-virus-related liver cirrhosis
Authors: Hye Young Jwa, Yoo-Kyung Cho, Eun Kwang Choi, Heung Up Kim, Hyun Joo Song, Soo-Young Na, Sun-Jin Boo, Seung Uk Jeong, Bong Soo Kim, Byoung-Wook Lee, Byung-Cheol Song
Journal: Clinical and Molecular Hepatology (2016)

Recent studies suggest that liver cirrhosis is reversible after administering oral nucleos(t)ide analogue therapy to patients with hepatitis B virus (HBV) infection. However, few studies have addressed whether esophageal varices can regress after such therapy. We report a case of complete regression of esophageal varices during entecavir therapy in patients with HBV-related liver cirrhosis, suggesting that complications of liver cirrhosis such as esophageal varices can regress after the long-term suppression of HBV replication. Keywords: Hepatitis B virus; Entecavir; Esophageal varices; Liver cirrhosis
CLINICAL EFFECTS OF TESTOSTERONE SUPPLEMENTATION AMONG HYPO-ANDROGENIC MEN WITH PREEXISTING SEVERE CORONARY ARTERY DISEASE: THE INTERMOUNTAIN HEART COLLABORATIVE STUDY
Authors: Tami L. Bair, Heidi May, Viet T. Le, Donald Lappe, Jeffrey Anderson, J. Muhlestein
Journal: Journal of the American College of Cardiology (2016)
Abstract 3447: Obatoclax analogue SC-2001 induced autophagy through SHP1/STAT3 pathway in hepatocelluar carcinoma.
Authors: Jung-Chen Su, Chun-Yu Liu, Wei-Tien Tai, Kuen-Feng Chen, Chung-Wai Shiau
Journal: Cancer Research (2013)

Abstract Obatoclax induced cancer cells apoptosis through targeting anti-Bcl-2 family. Previously, we have generated 20 obatoclax analogues with three synthetic steps and tested cytotoxicity in HCC cell lines. Among these analogues, SC-2001 not only inhibited anti-Bcl-2 family activity but also reduced STAT3 phosphorylation and subsequently repressed transcriptional activity of STAT3 targeting genes. Here, we further revealed that SC-2001 induced LC3-II with time and dose dependent manner in HCC cell line. We also observed that autophogosomes were induced with SC-2001 treated cells under electron microscope detection. Conversely, sodium vanadate, a phosphatase inhibitor, abolished the LC3 induction and autophagic effect in SC-2001 treated cells. In addition, overexpression of STAT3 in PLC5 cells attenuate autophagic effect with SC-2001 treatment. Genetic knockdown of SHP-1, a negative regulator of STAT3, by siRNA reduced autophagy induced by SC-2001. In summary, our data suggested that SC-2001 can induce autophagic cell death through, at least in part, SHP-1/STAT3 signaling pathway. (Supported by NSC-100-2325-B-010-007) Citation Format: Jung-Chen Su, Chun-Yu Liu, Wei-Tien Tai, Kuen-Feng Chen, Chung-Wai Shiau. Obatoclax analogue SC-2001 induced autophagy through SHP1/STAT3 pathway in hepatocelluar carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3447. doi:10.1158/1538-7445.AM2013-3447
Abstract 5310: Positron emission tomography imaging of endometrial cancer using an anti-EMP2 minibody
Authors: Maoyong Fu, Sarah Brewer, Jonathan Braun, Madhuri Wadehra
Journal: Cancer Research (2011)

Abstract Endometrial cancer is increasingly affecting pre-menopausal women, prompting a need to develop fertility-sparing therapy, and monitor response to treatment by quantitative non-invasive strategies. Epithelial membrane protein 2 (EMP2) is a tetraspan protein associated with surface localization and function of cancer-relevant integrin isoforms, and EMP2 expression in endometrial cancer correlates with increasing cancer stage and poor prognosis. As EMP2 is highly expressed in endometrial cancer, this pre-clinical study tested the feasibility of non-invasive detection of human endometrial tumor xenografts using a radiolabeled anti-EMP2 diabody and positron emission tomography (PET). EMP2 biodistribution in murine organ was determined by western blot and immunohistochemistry. Anti-EMP2 minibody (MB83) fragment was designed and transfected into CHO-K1 cells. Purified minibody was DOTA conjugated and the binding activity was tested by flow cytometry using endometrial cancer cell line, Hec-1A/EMP2 cells. Then conjugated minibody was chelated with Cu-64. In vivo biodistribution of Cu-64 labeled MB83 in Balb/c nu/nu mice were determined by microPET imaging and AMIDE sofeware. MB83 location was determined by microPET in mice bearing Hec1a/EMP2 xenograft. EMP2 expression was detectable in the lung but not other organs by either western or immunohistochemistry. The absence of detectable EMP2 protein in the organs reflects that the target tumor with high EMP2 protein could uptake anti-EMP2 antibody which could be observed by microPET. The specific uptake of MB83 minibody within the Hec1a/EMP2 tumor can be seen both visually and quantitatively. Selective tumor uptake became more specific over time. In contrast, 2-deoxy-2-[18F]fluoro-D- glucose (FDG) microPET uptake by HEC-1A/EMP2 was minimal, reflecting the poor detection of gynecologic cancer cell types by conventional FDG-PET imaging. These findings demonstrate the feasibility of imaging endometrial and other gynecological cancers which have upregulated EMP2 expression using recombinant anti-EMP2 antibodies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5310. doi:10.1158/1538-7445.AM2011-5310
Ectopic Mature Cerebral Tissue in the Nasal Cavity Incidentally Detected by 18F-FDG PET/CT
Authors: Filippo Lococo, Giorgio Treglia, Angelina Filice, Carmine Pernice, Annibale Versari, Massimiliano Paci, Cristian Rapicetta, Giorgio Sgarbi
Journal: Clinical Nuclear Medicine (2014)

Herein we describe a rare case of neuroglial heterotopia (ectopic mature cerebral tissue) incidentally detected by F-FDG PET/CT. A 52-year-old female patient underwent F-FDG PET/CT for metabolic characterization of a left pulmonary nodule. F-FDG PET/CT revealed increased radiopharmaceutical uptake corresponding to the pulmonary nodule pathologically described as adenocarcinoma. Furthermore, an area of increased F-FDG uptake corresponding to a lesion in the left nasal cavity was detected. Endoscopic biopsy of the nasal lesion showed the presence of ectopic mature cerebral tissue suggesting the presence of neuroglial heterotopia.
PWE-030 Entonox Use During Colonoscopy: A Survey Of English Bowel Cancer Screening Programme Colonoscopists
Authors: A Ball, J Campbell, SA Riley
Journal: Gut (2014)

<h3>Introduction</h3> Entonox may be used to improve patient experience during colonoscopy. Nitrous oxide is rapidly eliminated which minimises after effects and inconvenience to patients. Despite its advantages, Entonox is used in only a minority of procedures in the UK. We sought to understand the reasons for its low utilisation. <h3>Methods</h3> Colonoscopists within the English Bowel Cancer Screening Programme (BCSP) were invited to participate in a web-based survey, assessing the availability, current practices and perceptions of Entonox during colonoscopy. Respondents were able to select pre-defined answers or offer written responses. Free text responses were assessed using thematic analysis. Categorical data was compared using the χ2 test. <h3>Results</h3> The survey was completed by 208/298 (70%) of the English BCSP colonoscopists. Entonox was available to 152/208 (73%) respondents but this varied between NHS deaneries. Nearly half (47%) of the respondents stated that Entonox was used in &lt; 20% of examinations. Colonoscopists who administered Entonox frequently (&gt;20% of examinations) rated its efficacy (49% vs. 76%, OR: 3.3, p = 0.001) and usefulness (69% vs. 95%, OR: 8.4, p &lt; 0.0001) more favourably. But there were no differences in how they rated its safety (90% vs. 97%, OR: 4.2, p = 0.085), frequency of side effects (92% vs. 96%, OR: 2.3, p = 0.31) or influence on discharge time (70.4 vs. 79.5%, OR: 1.63, p = 0.26). Most respondents for whom nitrous oxide was available stated that they would use it if they were to have a colonoscopy themselves (74%). Most respondents reported their patients were advised to use Entonox ‘as required’ (92%) rather than continuously (8%) and from the start of colonoscopy rather than as rescue medication when other medications are inadequate. Some respondents never combined Entonox with other sedatives. Many respondents indicated that Entonox was used for the patients and the procedures which are expected to have least discomfort. Most of the colonoscopists for whom Entonox wasn’t available had considered introducing it (94%). Practical difficulties (37%) and satisfaction with current analgesics and sedation (28%) were the most common reasons it was not available. The introduction of the English flexible sigmoidoscopy screening programme was cited as the reason for its introduction by several respondents. <h3>Conclusion</h3> Entonox is used in a minority of colonoscopy examination. It is generally perceived to be safe, effective and most colonoscopists would use it if they required a colonoscopy. Entonox is often chosen when patients wish to avoid the inconvenience caused by intravenous sedation and analgesics. Its use is likely to increase with the introduction of the English screening programme. <h3>Disclosure of Interest</h3> None Declared.
The expression of the tight junction proteins ZO-1 / occludin and their regulatory cytokine, interleukin-8, and its receptor complex in human bladder cancer
Authors: Mark D. Haynes, Tracey A. Martin, Gareth Brown, Gareth Watkins, Philip N. Matthews, Wen G. Jiang
Journal: Cancer Research (2005)

3782  Introduction: The tight junction (TJ) complex performs a critical role in the maintenance of the physiological barrier between the urine and blood. There is evidence that a relationship may exist between reduced TJ protein expression and high grade disease / poor prognosis. This alteration in TJ expression may be a consequence of reduced differentiation seen in high grade, aggressive cancers. However, substances such as interleukin-8 (IL8) which disrupt the TJ of bladder cancer cells are associated with invasive bladder cancer. We have studied the expression of IL8, its receptor complex and tight junction proteins occludin and ZO-1 in normal bladder and bladder cancer specimens. Methods: Fresh samples of bladder cancer (n=30) and normal urothelium (n=8) were collected from patients undergoing surgical treatment for bladder cancer. Tissue was snap frozen in liquid nitrogen and stored at -80°C. Frozen sections (6μM) were cut for immunohistochemistry (IHC) and RNA extraction for RT-PCR. Staining intensity was measured using OPTIMAS software and statistical analysis using T-tests (Microsoft Excel). Results: IHC demonstrated expression of ZO-1 and occludin in normal urothelium localised to the lateral cell membrane. Staining intensity was reduced for both ZO-1 (mean±SD staining intensity 149.9±10.8 normal, 122.4± 6.7 cancer, p =
Mammillary Body
Authors: Pragati Jha, Krishan Kant Agarwal, Manas Kumar Sahoo, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2016)

Epilepsy is one of the most common neurological conditions, which affect nearly 1% of the entire population. We present F-FDG PET-CT findings of a mammillary body epileptic focus in a 50-year-old woman with a 5-year history of seizure and behavior disturbance and memory problems for the past 4 years.
Abstract 2440: Inhibition of SDF-1/CXCR4 dependent-metastases by the treatment with metabotropic glutamate receptor 5 (mGluR5) antagonists in oral cancer
Authors: Daisuke Uchida, Nobuyuki Kuribayashi, Tetsuya Tamatani, Hirokazu Nagai, Youji Miyamoto
Journal: Cancer Research (2011)

Abstract Previously, we identified a metastasis-candidate gene, metabotropic glutamate receptor (mGluR)-5 by using an oral cancer cell line, B88-SDF-1, which have an autocrine stromal cell-derived factor (SDF)-1/CXCR4 system and distant metastatic potentials in vivo. In this study, we examined the effect of mGluR5 antagonists on the SDF-1/CXCR4 dependent-metastases in oral cancer. We used 2 kinds of mGluR5-specific antagonists, 2-Methyl-6-(phenylethynyl)pyridine (MPEP) and 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP). These antagonists did not affect the growth of B88-SDF-1 cells, but did inhibit the enhanced-migration of the cells. Under these conditions, actin polymerization and pseudopodia formation were also inhibited by the treatment with MPEP and MTEP. In order to confirm the drug toxicities, these antagonists were intraperitoneally injected into wild-type mice for 4 weeks. All the mice injected with MPEP (5 mg/kg) and MTEP (5 mg/kg) did not show side effects, such as hematotoxicity, allergic reaction and body weight loss. When the B88-SDF-1 cells were transplanted into the vein of nude mice, these antagonists significantly inhibited the lung metastases of the cells. These results suggested that blockade of mGluR5, using antagonists such as MPEP and MTEP, may be effective at preventing metastasis in patients with CXCR4-related oral cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2440. doi:10.1158/1538-7445.AM2011-2440
Hypothermia in General Surgery
Authors: B. Eiseman, J. C. Owens, H. Swan
Journal: New England Journal of Medicine (1956)

DURING the past three years a voluminous literature has accumulated on the use of hypothermia in prolonging the safe period of circulatory occlusion during cardiac surgery, but little has been written on the use of hypothermia in general surgery. The purpose of this paper is to summarize our experience with the use of hypothermia in general surgery and to give the physiologic rationale for its employment.Clinical MaterialDuring this period from July, 1953, to May, 1956, we employed hypothermia for 41 noncardiac operative procedures. Of these, 11 were for neurosurgical operations and are not further considered in this . . .
Case 47-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, P.C. Pairolero, E.J. Mark
Journal: New England Journal of Medicine (1990)

Presentation of CaseA 51-year-old man was admitted to the hospital because of a history of hemoptysis and epistaxes and cavitary lesions of the left lung.The patient was well until three months earlier, when a cough developed that was productive of blood-streaked, purulent sputum; the cough soon resolved. Two months before entry a right parotid mass that had been present and stable for five years increased in size and became painful with a "throbbing" sensation. Evaluation elsewhere before a contemplated excision of the mass included an x-ray film of the chest (Fig. 1 ) that showed a cavitary lesion, 2 . . .
A Comparison of Directional Atherectomy with Coronary Angioplasty in Patients with Coronary Artery Disease
Authors: Eric J. Topol, Ferdinand Leya, Cass A. Pinkerton, Patrick L. Whitlow, Berthold Hofling, Charles A. Simonton, Ronald R. Masden, Patrick W. Serruys, Martin B. Leon, David O. Williams, Spencer B. King, Daniel B. Mark, Jeffrey M. Isner, David R. Holmes, Stephen G. Ellis, Kerry L. Lee, Gordon P. Keeler, Lisa G. Berdan, Tomoaki Hinohara, Robert M. Califf
Journal: New England Journal of Medicine (1993)

Directional coronary atherectomy is a new technique of coronary revascularization by which atherosclerotic plaque is excised and retrieved from target lesions. With respect to the rate of restenosis and clinical outcomes, it is not known how this procedure compares with balloon angioplasty, which relies on dilation of the plaque and vessel wall. We compared the rate of restenosis after angioplasty with that after atherectomy.
Facial Paralysis Secondary to Extensive Perineural Spread of Adenocarcinoma of the Parotid Gland Identified by PET/CT
Authors: Dwight M. Achong, Martin Zloty
Journal: Clinical Nuclear Medicine (2016)

Brain MRI in an 82-year-old man with presumed Bell’s palsy revealed a clinically unsuspected right parotid gland mass but no other acute findings. Biopsy revealed poorly differentiated adenocarcinoma. Staging 18F-FDG PET/CT revealed an FDG-avid parotid mass, abnormal FDG uptake along the course of the facial nerve from mass to skull base, and multiple FDG-avid right level II neck lymph nodes and hepatic metastases. The PET/CT findings and prolonged clinical course suggest that diffuse perineural spread of tumor from a smoldering parotid neoplasm, and not idiopathic Bell’s palsy, was responsible for the patient’s facial paralysis.
Freestanding Cancer Centers: The Wave of the Future? Or Is the Tide Receding?
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Freestanding Cancer Centers: The Wave of the Future? Or Is the Tide Receding? Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 3, 1 February 1989, Pages 182–183, https://doi.org/10.1093/jnci/81.3.182 Published: 01 February 1989
Abstract 3081: miR-885-5p, a p53-activated microRNA, inhibits the Wnt/β-catenin signaling pathway and hepatocellular carcinoma metastasis.
Authors: Zhuhong Zhang, Jing Yin, Dan Lv, Chenghu Liu, Jian Yang, Antao Chang, Peiqing Sun, Si Chen, Dwayne Stupack, Yaping Tian, Rong Xiang
Journal: Cancer Research (2013)

Abstract The regulation of hepatocelluar carcinoma (HCC) progression by microRNAs (miRNAs) has attracted attention in recent years. Our previous study reported that the levels of circulating miR-885-5p were significantly up-regulated in patients with HCC and chronic hepatitis B (CHB). However, the role of miR-885-5p in HCC metastasis and the underlying mechanisms remain unknown. In this study, we used in situ hybridization to analyze the expression of miR-885-5p in HCC tissues and found that its expression was negatively associated with TNM stage of HCC. Consistent with this, the expression of miR-885-5p was negatively correlated with the invasive and metastatic abilities of human HCC cell lines. Kaplan-Meier analysis revealed that miR-885-5p levels correlated with the survival of HCC patients. Furthermore, enforced expression of miR-885-5p in high-metastatic HCC cells inhibited migration and invasion in vitro and in vivo. In addition, we identified that miR-885-5p directly targeted genes encoding the β-catenin CTNNB1 and the transcription factor TCF4, leading to decreased activity of the Wnt/β-catenin signaling pathway, which in turn contributes to metastasis in various cancers, including HCC. Notably, our results also showed that p53 up-regulated the expression of miR-885-5p and significantly inactivated the Wnt/β-catenin signaling pathway in HCC cells. We found that miR-885-5p levels correlated with wild-type TP53 status in HCC tissues. Taken together, these findings suggest that miR-885-5p is a negative regulator of HCC metastasis and indicate a potent rationale for developing miR-885-5p as a potential therapeutic agent against HCC metastasis. Citation Format: Zhuhong Zhang, Jing Yin, Dan Lv, Chenghu Liu, Jian Yang, Antao Chang, Peiqing Sun, Si Chen, Dwayne Stupack, Yaping Tian, Rong Xiang. miR-885-5p, a p53-activated microRNA, inhibits the Wnt/β-catenin signaling pathway and hepatocellular carcinoma metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3081. doi:10.1158/1538-7445.AM2013-3081 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
THE ASSOCIATION OF INVASIVE INTRA-PROCEDURAL HEMODYNAMIC PARAMETERS WITH LONG-TERM OUTCOME IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Sarkis Kiramijyan, Edward Koifman, Itsik Ben-Dor, Zachary Jerusalem, Sandeep Kumar, Marco Magalhaes Pereira, Romain Didier, Smita Negi, Toby Rogers, Arie Steinvil, Sang Yeub Lee, Kang Won Yu, Jiaxiang Gai, Rebecca Torguson, Petros Okubagzi, Michael Lipinski, Michael Gaglia, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2016)