tbuckley/cabot-search huggingface dataset:
FRI0581 Utility of the Glasgow Prognostic Score in Systemic Lupus Erythematosus, In a Single Center Cohort of 130 Patients
Authors: C. Delcea, A. Dima, C. Jurcut, S. Caraiola, C. Badea, D. Nitescu, E. Balanescu, A. Nicolau, V. Pompilian, R. Ionescu, C. Baicus, G.A. Dan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Glasgow Prognostic Score (GPS) is a simple, systemic inflammation-based prognostic score used mostly in oncology and intensive-care. <h3>Objectives</h3> We aimed to investigate the utility of GPS in assessing disease activity in patients with systemic lupus erythematosus (SLE). <h3>Methods</h3> Patients admitted consecutively to our department were prospectively enrolled in the study. Clinical and biological parameters were assessed in each participant. Disease activity was quantified using Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Systemic Lupus Activity Measure (SLAM) and European Consensus Lupus Activity Measurement (ECLAM). GPS was calculated using 1 point for C reactive protein&gt;10mg/L and 1 point for hypoalbuminemia. <h3>Results</h3> Our study group included 130 patients with a mean age of 46.58±12.69 years old and 90% female predominance, out of which 17 (13.07%) had a GPS≥1. Median ECLAM score was 2[0-7.5], median SLAM score was 4[0-24] and median SLEDAI score 6[0-48]. Patients with a GPS≥1 had a higher ECLAM score compared to those with a GPS=0 (3[0-10.5] vs. 2[0-7], p=0.007), a higher SLAM score (7[0-22] vs. 4[1-14], p=0.003), a higher SLEDAI score (8[0-48] vs. 4.5[0-30], p=0.006) and a higher erythrocyte sedimentation rate (ESR) (24[10-90] vs. 13.5[2-61], p=0.03). ROC curve analysis identified ECLAM and SLAM scores as predictors of a GPS≥1 with an AUC of 0.825 (95%CI 0.0.686-0.964, p=0.01) and 0.740 (95%CI 0.483-0.998, p=0.07) respectively. Elevated ESR was also associated with a GPS≥1 with an AUC of 0.819 (95%CI 0.693-0.945, p=0.01). <h3>Conclusions</h3> GPS was correlated with disease activity in patients with SLE. A simple systemic inflammation score, it could be used as an auxiliary tool for their assessment. <h3>Acknowledgements</h3> This paper is supported by POSDRU/159/1.5/S/137390. <h3>Disclosure of Interest</h3> None declared
Review of clinical and animal studies comparing the cardiovascular effects of doxepin and other tricyclic antidepressants
Authors: D J Luchins
Journal: American Journal of Psychiatry (1983)

On the basis of early reports suggesting that doxepin has fewer cardiovascular effects than do other tricyclic antidepressants, doxepin continues to be recommended for the treatment of depression in cardiac patients and in the elderly. However, these reports have been criticized, and other evidence has suggested opposite conclusions. To clarify this issue, the author reviewed clinical and animal studies and found that, in general, doxepin has an effect comparable to the effects of other tricyclic antidepressants on cardiac conduction, cardiac rhythm, heart rate, blood pressure, and cardiac mechanics.
An 8-year follow-up of patients with DSM-III-R psychotic depression, schizoaffective disorder, and schizophrenia
Authors: D Tsuang, W Coryell
Journal: American Journal of Psychiatry (1993)

The purpose of this study was to investigate the long-term outcome of patients with functional psychoses. The functional status of patients with mood-congruent and mood-incongruent psychotic depression, schizoaffective disorder, and schizophrenia was examined.Ninety-two inpatients with nonmanic and nonorganic functional psychoses who had been discharged from the hospital were identified through inpatient records. A blind rater used DSM-III-R criteria to assign research diagnoses to the patients on the basis of the data gathered at admission. Seventy-one patients were located 8 years later, and personal interviews were conducted with them.Baseline diagnosis was a powerful predictor of long-term outcome, even after controlling for age at onset and duration of episode at admission. Patients with psychotic depression had much better outcomes than patients with schizoaffective disorder or schizophrenia. Fourteen (43.8%) of 32 patients with psychotic depression were free from psychosis at follow-up, in marked contrast to those who had schizoaffective disorder or schizophrenia, none of whom had recovered. Patients with schizoaffective disorder could not be distinguished from patients with schizophrenia.The prognosis of patients with major depression with mood-incongruent features most closely resembles that of depressed patients with mood-congruent features, while patients with DSM-III-R schizoaffective disorder have a prognosis resembling that of schizophrenic patients. Patients with psychotic affective disorders have a much higher likelihood of recovering from psychosis than do schizophrenic patients.
Case 17-1967
Authors: John Hedley-Whyte, Robert E. Scully
Journal: New England Journal of Medicine (1967)

Presentation of CaseA sixty-six-year-old woman entered the hospital because of difficulty in breathing.She had been well until seven days previously, when the left leg became painful, but without swelling. The pain persisted, and on the day before admission dyspnea developed. On the following morning she went to a physician with the complaint of a cough, dyspnea and a mild sore throat. She appeared dyspneic and slightly cyanotic and had a dry, hacking cough accompanied by frequent gagging. She was afebrile. The physician diagnosed an asthmatic attack and administered epinephrine, 0.3 ml. of a 1:1000 solution, aminophylline, 250 mg., . . .
Cold agglutinin autoantibodies in psychiatric patients: their relation to diagnosis and pharmacological treatment
Authors: B Spivak, M Radwan, J Brandon, A Molcho, R Ohring, S Tyano, A Weizman
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to compare titers of cold agglutinins in schizophrenic patients with those in patients with major affective disorders and in normal healthy subjects. One hundred sixty-six psychiatric patients and 37 healthy comparison subjects were included in the study. Ninety of the patients suffered from schizophrenia, 54 from bipolar disorder, and 22 from major depression. Venous blood samples were obtained from all subjects between 8:00 and 10:00 a.m. and were immediately tested for cold agglutinin titers.A high frequency (42.2%) of positive cold agglutinin titers was detected in the schizophrenic patients, compared with the bipolar (11.1%) and unipolar (9.0%) patients and the comparison group (8.1%). The investigators did not find any pharmacological effect on these results.The findings suggest that, at least in this group, positive cold agglutinin titers are associated with schizophrenia. However, this observation cannot provide direct evidence for the involvement of viral or autoimmune factors in schizophrenia.
PYRIDOXINE-RESPONSIVE ANEMIA
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Necrolytic Migratory Erythema–like Skin Lesion During Gefitinib Treatment
Authors: Jun Young Seong, Sook Hyun Kong, Yu Sung Choi, Ho Seok Suh
Journal: JAMA Dermatology (2016)

The lack of consistent oversight of online content can result in inappropriately technical patient education resources. 6Given that a majority of the patient education sources from the 20 dermatology organizations were written above the National Institutes of Health-recommended reading level, these existing resources should be revised to reach a broader patient audience.A limitation to this study is the lack of patient feedback in assessing the quality of online health care resources.Using quality assessment metrics to subjectively evaluate the online user experience may capture criticisms missed by our quantitative approach.Participants could reflect on the quality of nontextual components such as graphics, website design, interactivity, and user friendliness.A greater emphasis must be placed on developing simpler online dermatologic education resources, given the influence these materials can have on patient decision making in the clinical setting.
Stopping TB in Europe: some progress but still not there
Authors: D Falzon, Y Kudjawu, J  C Desenclos, K Fernandez de la Hoz, A Dadu, R Zaleskis
Journal: Eurosurveillance (2008)

Overview of the epidemiological situation in 2006. The latest available information from countries in the World Health Organization (WHO) European Region carries important signals about the tuberculosis (TB) situation in this part of the world [1]. The total number of TB cases reported in the Region was slightly lower in 2006 than in 2005 (422,830 versus 426,457), reflecting a decrease in three-fourths of the reporting countries. Most TB cases in 2006 (73%) were reported by 12 former Soviet Union republics in the East, 21% by the European Union and West (EU and West) and 6% by the remaining countries in the Balkans (Table 1; for the composition of geographical areas see Box). National TB notification rates ranged from 4 to 282 per 100,000 population. The total TB notification rate for the whole Region has increased very slightly between 2002 and 2006, from 46 to 48 cases per 100,000, although rates of previously untreated TB cases appear to be on the decrease in both the East and West (Figure 1). We describe the main epidemiological features of TB cases notified in each of the abovementioned areas using surveillance data reported by the countries themselves.
Screening for Type 2 Diabetes Mellitus in Adults: Recommendations and Rationale
Journal: Annals of Internal Medicine (2003)

This statement summarizes the current U.S. Preventive Services Task Force (USPSTF) recommendations on screening for type 2 diabetes in adults and updates the 1996 recommendations on this topic. The complete USPSTF recommendation and rationale statement on this topic, which includes a brief review of the supporting evidence, is available through the USPSTF Web site (www.preventiveservices.ahrq.gov) and the National Guideline Clearinghouse (www.guideline.gov) and in print through the Agency for Healthcare Research and Quality (AHRQ) Publications Clearinghouse (call 800-358-9295 or e-mail ahrqpubs@ahrq.gov). The complete information on which this statement is based, including evidence tables and references, is available in the accompanying article in this issue and in the summary of the evidence and systematic evidence review on this topic on the Web sites already mentioned. The summary of the evidence is also available in print through the AHRQ Publications Clearinghouse. * For a list of the members of the U.S. Preventive Services Task Force, see the Appendix.
Retroflexion-induced perforation during colonoscopy after polypectomy: a word of caution
Authors: Anil John, Saad Al Kaabi, Ragesh Thandassery, Nazeeh Dweik
Journal: Endoscopy (2015)

A 75-year-old man underwent colonoscopy (Pentax colonoscope, EC3970Li, air insufflation; Tokyo, Japan) for colorectal cancer screening and was found to have a small pedunculated polyp (1 cm) in the rectum ([Fig. 1 a]). A snare polypectomy was performed and the procedure was uncomplicated.
On the Heredity of Glioblastoma&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: B HARVALD, M HAUGE
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article On the Heredity of Glioblastoma Get access B. Harvald, M.D., B. Harvald, M.D. Professor Tage Kemp Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Hauge, M.D. M. Hauge, M.D. Professor Eduard Busch Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 3, September 1956, Pages 289–296, https://doi.org/10.1093/jnci/17.3.289 Published: 01 September 1956 Article history Received: 31 January 1956 Published: 01 September 1956
Gas6/Axl Axis Contributes to Chemoresistance and Metastasis in Breast Cancer through Akt/GSK-3β/β-catenin Signaling
Authors: Cun Wang, Haojie Jin, Ning Wang, Shaohua Fan, Yanyan Wang, Yurong Zhang, Lin Wei, Xuemei Tao, Dishui Gu, Fangyu Zhao, Jingyuan Fang, Ming Yao, Wenxin Qin
Journal: Theranostics (2016)

Chemoresistance in breast cancer has been of great interest in past studies.However, the development of rational therapeutic strategies targeting chemoresistant cells is still a challenge in clinical oncology.By integrating data from global differences of gene expression and phospho-receptor tyrosine kinases between sensitive parental cells (MCF-7) and doxorubicin-resistant cells (MCF-7/ADR), we identified Axl as a potential target for chemoresistance and metastasis in multidrug resistant breast cancer cells.We analyzed Axl expression in 57 breast cancer cell lines and detected a dramatic increase in its expression level in mesenchymal breast cancer cell lines.Axl silencing suppressed invasive and metastatic potentials of chemoresistant breast cancer cells as well as increased elimination of cancer cells when combined with doxorubicin.Furthermore, in preclinical assays, an Axl inhibitor R428 showed increased cell death upon doxorubicin treatment.Additionally, using phospho-kinase array based proteomic analysis, we identified that Akt/GSK-3β/β-catenin cascade was responsible for Axl-induced cell invasion.Nuclear translocation of β-catenin then induced transcriptional upregulation of ZEB1, which in turn regulated DNA damage repair and doxorubicin-resistance in breast cancer cells.Most importantly, Axl was correlated with its downstream targets in tumor samples and was associated with poor prognosis in breast cancer patients.These results demonstrate that Gas6/Axl axis confers aggressiveness in breast cancer and may represent a therapeutic target for chemoresistance and metastasis.
CUMULATED INDEX MEDICUS
Authors: W K MORGAN
Journal: JAMA (1965)

The recent publication of the 1964<i>Cumulated Index Medicus</i>(CIM) marks the fifth year that the National Library of Medicine and the American Medical Association have cooperated to produce the most comprehensive index to the world's medical literature. This year's<i>CIM</i>contains 145,218 articles, an increase of more than 15,000 from last year and 20,000 from 1960, for an average of nearly 400 articles per day. The first volume of<i>Index Medicus</i>appeared in 1879, four years before the first issue ofThe Journal. The purpose of the original<i>Index Medicus</i>was, in the words of its founder, Dr. John Shaw Billings, to index monthly "all current medical journals and transactions of value, so far as they can be obtained." Bibliographic control was difficult even in the days when there were only 850 medical journals and 20,000 substantive articles published each year. Dr. Robert Fletcher, Dr. Billings' assistant, was quoted
GRADUATE MEDICAL EDUCATION IN THE UNITED STATES
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Psychiatric care and health insurance reform
Authors: S S Sharfstein, A M Stoline, H H Goldman
Journal: American Journal of Psychiatry (1993)

Concerns about cost, access, and quality of health care in the United States have led to a variety of legislative proposals that would reform our health care system and its financing. Health insurance benefits for mental illness, including substance abuse, are treated differently from medical/surgical benefits, with stricter limits on outpatient visits and hospital days. Medicare, Medicaid, and most private health insurance plans contain this historic disparity of coverage for mental illness compared to general medical illness. Psychiatric services are also distinguishable because of the large public sector reimbursement for mental illness treatment and support. Principles for a more equitable design of mental health benefits include a non-discriminatory approach; payment on the basis of service rather than diagnosis; application of cost containment for care of mental illness on the same basis as care of general medical illness; retention of the public sector as a backup system for high-cost, long-term care; encouragement of lower-cost alternatives to the hospital through the development of a continuum of care; and a recognition of the distinction between psychotherapy and medical management. All current approaches to universal health care fall short of these principles. A research agenda is needed now more than ever in order to articulate the case for complete coverage of mental illness and substance abuse.
Case 30-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Charles A. Hales, Eugene J. Mark
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 43-year-old woman was admitted to the hospital because of severe dyspnea and lethargy.She was well until 38 months earlier, when she first noticed a lump in the right breast. A mammographic study, performed elsewhere, was reported to be negative. Eight months later she felt a lump in the right side of the neck and was admitted to this hospital.The patient was premenopausal. The first of her three children was born when she was 27 years of age, and the last was born at 35 years. There was a history of Hashimoto's thyroiditis, for which . . .
Studies of Some Antigens of the L Strain Mouse Fibroblast&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Kite, Joseph H., Merchant, Donald J.
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Studies of Some Antigens of the L Strain Mouse Fibroblast Get access Joseph H. Kite, Jr., Joseph H. Kite, Jr. Department of Bacteriology, The University of Michigan Medical School, Ann Arbor, Michigan Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald J. Merchant Donald J. Merchant Department of Bacteriology, The University of Michigan Medical School, Ann Arbor, Michigan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 26, Issue 2, February 1961, Pages 419–434, https://doi.org/10.1093/jnci/26.2.419 Published: 01 February 1961 Article history Received: 15 August 1960 Published: 01 February 1961
Pulsus Alternans
Authors: K Cha, R H Falk
Journal: New England Journal of Medicine (1996)

Figure 1. Physical examination of two patients with severe left ventricular failure revealed pulsus alternans in the radial pulse. Pulsus alternans is a physical finding characterized by a regular alternation of the force of the arterial pulse. It almost invariably indicates the presence of severe left ventricular systolic dysfunction.Panel A shows a simultaneous electrocardiogram (ECG), phonocardiogram, and carotid-pulse tracing in a 64-year-old man with an ejection fraction of 15 percent due to dilated cardiomyopathy. Alternating strong and weak beats are seen in the carotid pulse tracing that corresponded to an alternation of approximately 40 mm Hg in the systolic . . .
DISLOCATION OF CARPAL SCAPHOID
Authors: J PUJO DIAZ
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Consent, competence, and confidentiality
Authors: Vic Larcher
Journal: BMJ (2005)

Adolescence represents the final phase in the transition from the dependence of infancy to the autonomy of adulthood.It can be difficult for young people, parents, and health professionals alike, because of the nature and speed of change.Uncertainty over ethical and legal rights and responsibilities may lead professionals to refuse to see adolescents aged under 16 years on their own for fear of incurring parental wrath or even legal action.Disputes may arise in relation to an adolescent's competence to seek, consent to, or refuse medical treatment, and his or her right to confidentiality.In most cases these disputes can be resolved by discussion, compromise, and partnership, but in extreme circumstances the courts may be involved.