tbuckley/cabot-search huggingface dataset:
Role of Conventional Childhood Risk Factors Versus Genetic Risk in the Development of Type 2 Diabetes and Impaired Fasting Glucose in Adulthood: The Cardiovascular Risk in Young Finns Study
Authors: Niina Pitkänen, Markus Juonala, Tapani Rönnemaa, Matthew A. Sabin, Nina Hutri-Kähönen, Mika Kähönen, Terho Lehtimäki, Jorma S.A. Viikari, Olli T. Raitakari
Journal: Diabetes Care (2016)

We examined whether the addition of novel genetic risk variant data to conventional childhood risk factors improves risk assessment of impaired fasting glucose (IFG) and type 2 diabetes in adulthood.An association of a weighted genetic risk score (wGRS) based on 73 risk variants with IFG and type 2 diabetes was analyzed in 2,298 participants of the Cardiovascular Risk in Young Finns Study who were followed for 24-31 years from childhood to adulthood. In addition, the value of the wGRS in pediatric prediction of type 2 diabetes was examined.Of the 2,298 participants, 484 (21.8%) and 79 (3.4%) had IFG or type 2 diabetes in adulthood, respectively. Adjusting for age, sex, baseline BMI, parental diabetes, mother's BMI, fasting insulin concentration, systolic blood pressure, and smoking status, wGRS was associated with an increased risk of IFG (odds ratio 1.64 [95% CI 1.33-2.01] per unit increase in the wGRS) and type 2 diabetes (2.22 [1.43-3.44]). Incorporating wGRS into pediatric risk models improved model discrimination and reclassification properties. Area under the receiver operating curve improved for IFG (from 0.678 to 0.691, P = 0.015), combined IFG and type 2 diabetes outcome (from 0.678 to 0.692, P = 0.007), and type 2 diabetes (from 0.728 to 0.749, P = 0.158). The net reclassification improvement and integrated discrimination improvement were significant for all outcomes.A multifactorial approach combining genetic and clinical risk factors may be useful in identifying children at high risk for adult IFG and type 2 diabetes.
The EUVAC-NET survey: national pertussis surveillance systems in the European Union, Switzerland, Norway, and Iceland
Authors: J- E Schmidt, A E Tozzi, L Rava, S Glismann
Journal: Eurosurveillance (2001)

A questionnaire was mailed out to member states of the European Union (EU) plus Switzerland, Norway, and Iceland, to inquire about the type of information routinely recorded in national pertussis surveillance systems. Information was requested on surveillance methods, type of information recorded for cases of pertussis, vaccination schedule, type of vaccine used, and methods for estimating vaccination coverage. Local surveillance methods, vaccination strategies, and methods to estimate vaccination coverage were found to differ widely across the participating countries. The results of the questionnaire survey show, however, that there are comparable subsets of variables common to many countries. Future activities of the EUVAC-NET project will include defining the homogeneous elements in national systems and to group appropriately those countries with common surveillance features.
PNR-18PALB2 (PARTNER AND LOCALIZER OF BRCA2) HETEROZYGOUS GERMLINE MUTATION IN A CHILD WITH EXTRA OSSEOUS EWING'S SARCOMA (EOEWS) OF BRAIN AND RADIATION-INDUCED METASTATIC MELANOMA (MM)
Authors: Sri Gururangan, Kristin Schroeder, Herbert Fuchs, Thomas Cummings
Journal: Neuro-Oncology (2016)
June 10, 1912: A Discussion on Syphilis, with Special Reference to (A) Its Prevalence and Intensity in the Past and at the Present Day; (B) Its Relation to Public Health, Including Congenital Syphilis; (C) the Treatment of the Disease: Opening Address, with special reference to the Treatment of the Disease
Authors: D'Arcy Power
Journal: Journal of the Royal Society of Medicine (1912)
Protecting asplenic individuals from fulminant pneumococcal disease
Authors: H Nohynek
Journal: Eurosurveillance (2010)

Preview this article: Protecting asplenic individuals from fulminant pneumococcal disease, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/23/art19584-en-1.gif
P264 A multi-centre review of the management of pulmonary Non-Tuberculous Mycobacterial (NTM) infection in HIV-negative subjects: Abstract P264 Table 1
Authors: TM Rawson, A Abbara, K Kranzer, A Ritchie, J Milburn, T Brown, D Adeboyeku, J Buckley, RN Davidson, M Berry, OM Kon, L John
Journal: Thorax (2015)

<h3>Introduction</h3> Non-Tuberculous Mycobacteria (NTM) are ubiquitous in the environment meaning clinical, radiological and microbiological criteria are important in diagnosing NTM lung disease. A multicentre, retrospective review was performed to characterise NTM disease within our region and describe the outcomes of current management. <h3>Methods</h3> All NTM positive sputum samples received by the National Mycobacterium Reference Laboratory (NMRL) from Imperial College NHS Healthcare and North West London Hospitals NHS Trusts between 2010–2014 were extracted. HIV-negative individuals with ≥2 positive sputum samples or ≥1 positive bronchoalveolar lavage were included. Demographic, clinical, radiological, microbiological, management and outcome data was obtained from electronic records. <h3>Results</h3> 1190 NTM sputum samples were identified from 822 individuals. 152 individual patients met inclusion criteria for analysis. Table 1 describes cohort demographics. Within the cohort 48/152 (32%) were treated for NTM disease. All treated subjects and 74/104 (71%) non-treated subjects met international guidelines for diagnosis of NTM infection, which included positive clinical, radiological (cavities or bronchiectasis +/- nodules or infiltrates) and microbiological criteria. <i>Mycobacterium avium complex</i> (MAC) was the most commonly isolated (68/152; 45%) and treated organism (21/48; 44%) followed by <i>Mycobacterium kansasii</i> (11/48; 23%). 19/48 (40%) completed treatment (median duration: 17 months [IQR: 12–24]). 10/48 (21%) remain on treatment (median duration: 18 months [IQR: 11–36]), 11/48 (23%) stopped treatment due to side effects and 13/48 (27%) were either lost to follow up or treated for <i>Mycobacterium tuberculosis</i>. Of those treated, 29/48 (60%) culture converted; 23/29 (79%) remain negative at 12 months post culture conversion. Of 19/48 who completed treatment, 5/19 (26%) had symptomatic or radiological disease progression compared to 11/28 (39%) who did not complete treatment. 11/48 (23%) patients died within the treatment group. Within the untreated subjects who met international guidelines for NTM infection (74/104), mortality was 19/74 (26%) (p = 0.83). <h3>Discussion</h3> NTM is a challenging disease with only 39% of eligible subjects receiving treatment and a high associated mortality. Furthermore, only 40% starting treatment completed it and the 21% who remain on treatment have been treated for a median duration of 18 months to date. Unlike similar HIV-negative UK cohorts, MAC pulmonary disease is the most prevalent.
Long-term outcome of endoscopic submucosal dissection for early gastric cancer compared to surgical resection.
Authors: Eun Hui Sim, Byung-Wook Kim, Ji Hee Kim, Jin-Jo Kim
Journal: Journal of Clinical Oncology (2014)

120 Background: Endoscopic submucosal dissection (ESD) is now accepted as an alternative to surgery for the treatment of early gastric cancer (EGC). However, long-term clinical outcome of ESD for EGC compared to surgical resection has not been evaluated. The aim of this study is to evaluate the clinical outcome of ESD for EGC compared to surgical resection. Methods: A retrospective analysis was performed in 152 patients who underwent ESD or surgical resection for EGC according to Gotoda’s extended criteria from 2006 and 2008 in Incheon St. Mary’s Hospital and Seoul St. Mary’s Hospital, The Catholic University of Korea. Overall survival and recurrence rates were compared between the two groups. Results: A total of 56 patients underwent surgical gastrectomy and 96 patients underwent ESD. The medial follow-up was 76 months in surgical resection group and 71 months in ESD group. Metachronous recurrences including dysplasia were found in 9 patients in ESD group and none in surgical resection group (P=0.001). There was no significant difference between the groups in overall survival. Conclusions: Gotoda’s extended criteria for ESD might be acceptable for the treatment of EGC considering the oval survival. However, meticulous surveillance program should be established because metachronous recurrence is more common after ESD.
Treatment of Perforated Peptic Ulcer
Authors: John J. Byrne
Journal: New England Journal of Medicine (1962)

PERFORATION is a serious complication of peptic ulceration. Despite low mortality rates reported in various selected series, the average mortality rate in large general hospitals ranges from 10 to 20 per cent.This mortality is due to extensive fluid loss into the abdominal cavity, secondary peritoneal bacterial infection and a weakened cardiopulmonary reserve of the patient. These conditions account for the signs and symptoms that presented a grave prognosis in a series of 1904 patients studied at the Cook County Hospital: temperature over 102°F.; abdominal distention; pulse rate over 120; blood pressure below 80 mm. of mercury on entry; respirations . . .
Manic-depressive illness among poor urban Hispanics
Authors: B E Jones, B A Gray, E B Parson
Journal: American Journal of Psychiatry (1983)

Manic-depressive illness is reported to occur infrequently among some racial or ethnic groups and among lower socioeconomic groups. The authors investigated the incidence of manic-depressive illness among a random sample of 90 lower socioeconomic Hispanic patients admitted to the psychiatric inpatient unit of an urban hospital. They made a retrospective diagnosis based on DSM-III criteria and independent of the hospital diagnosis. Ten patients (11%) were diagnosed as manic-depressive--a rate three times the national admission rate. The authors discuss the significance of this finding and its relationship to sociocultural aspects of the Hispanic patient.
NU-14THE PEDIATRIC NEURO-ONCOLOGY AND PALLIATIVE CARE TEAMS: WORKING TOGETHER TO MAXIMIZE MEDICAL AND PSYCHOSOCIAL SUPPORT AT THE END OF LIFE
Authors: Emily Owens Pickle, Ana Aguilar-Bonilla, Michelle Richey, Amie Deak, Rachel Gray, Blaine Pitts, Amy Smith
Journal: Neuro-Oncology (2016)
Validation Of a Comprehensive Health Status Assessment Scale In Older Patients (≥ 65 years) With Hematological Malignances. Gah Study
Authors: Santiago Bonanad, Ernesto Perez Persona, Itziar Oiartzabal, Bernardo Gonzalez, Carlos Fernandez-Lago, Maria Teresa Zudaire, Mercedes Gironella, Alfonso Soler, David Valcarcel, Jose Ángel Hernández-Rivas, Carmen Marrero, Montserrat Arnan, Carmen Olivier, Pau Abrisqueta, Blanca Xicoy, Josep Sarrá, Benet Nomdedeu, Eva González, Jesus Martinez, José González-Campos, Cristina Encinas, Almudena Laiglesia, Cristina Fernández-Maqueda, Isidro Jarque, Christelle Ferra, José Falantes, Estrella Carrillo, Cristina Muñoz, J Feliú, Marta Durán, Marina Marcos, Silvia López, Alfonso J Cruz-Jentoft, Javier De La Rubia
Journal: Blood (2013)
Development of Pulmonary Tumors in Mice Segregated With Respect to The Three Genes : Dominant Spotting, Caracul, and Fused
Authors: Margaret K. Deringer, W. E. Heston
Journal: JNCI Journal of the National Cancer Institute (1955)

Development of Pulmonary Tumors in Mice Segregated With Respect to The Three Genes : Dominant Spotting, Caracul, and Fused Get access Margaret K. Deringer, Margaret K. Deringer National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Heston W. E. Heston National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 3, December 1955, Pages 763–768, https://doi.org/10.1093/jnci/16.3.763 Published: 01 December 1955 Article history Received: 18 July 1955 Published: 01 December 1955
Influence of the Mammary Tumor Agent on the Longevity of Hosts Bearing a Transplanted Tumor
Authors: Morris K. Barrett, Margaret K. Deringer, Thelma B. Dunn
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Influence of the Mammary Tumor Agent on the Longevity of Hosts Bearing a Transplanted Tumor Get access Morris K. Barrett, Morris K. Barrett National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer, Margaret K. Deringer National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn Thelma B. Dunn National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 1, August 1952, Pages 109–119, https://doi.org/10.1093/jnci/13.1.109 Published: 01 August 1952 Article history Received: 31 March 1952 Published: 01 August 1952
A comprehensive approach to psychiatric diagnosis
Authors: J S Strauss
Journal: American Journal of Psychiatry (1975)

The author discusses problems of the typological diagnostic system currently used in psychiatry, which focuses primarily on symptoms in classifying psychiatric disorders. He describes a comprehensive diagnostic system that would involve routine evaluation of five patient characteristics: symptoms, circumstances associated with symptoms, previous duration and course of illness, quality of personal relationships, and level of work function. He suggests that such a multivariable approach to psychiatric diagnosis can provide valuable information about the patient to clinicians, researchers, and other mental health workers.
Remodeling of the Epithelial–Connective Tissue Interface in Oral Epithelial Dysplasia as Visualized by Noninvasive 3D Imaging
Authors: Rahul Pal, Tuya Shilagard, Jinping Yang, Paula Villarreal, Tyra Brown, Suimin Qiu, Susan McCammon, Vicente Resto, Gracie Vargas
Journal: Cancer Research (2016)

Early neoplastic features in oral epithelial dysplasia are first evident at the basal epithelium positioned at the epithelial-connective tissue interface (ECTI), separating the basal epithelium from the underlying lamina propria. The ECTI undergoes significant deformation in early neoplasia due to focal epithelial expansion and proteolytic remodeling of the lamina propria, but few studies have examined these changes. In the present study, we quantitated alterations in ECTI topography in dysplasia using in vivo volumetric multiphoton autofluorescence microscopy and second harmonic generation microscopy. The label-free method allows direct noninvasive visualization of the ECTI surface without perturbing the epithelium. An image-based parameter, "ECTI contour," is described that indicates deformation of the ECTI surface. ECTI contour was higher in dysplasia than control or inflamed specimens, indicating transition from flat to a deformed surface. Cellular parameters of nuclear area, nuclear density, coefficient of variation in nuclear area in the basal epithelium and collagen density in areas adjacent to ECTI were measured. ECTI contour differentiated dysplasia from control/benign mucosa with higher sensitivity and specificity than basal nuclear density or basal nuclear area, comparable with coefficient of variation in nuclear area and collagen density. The presented method offers a unique opportunity to study ECTI in intact mucosa with simultaneous assessment of cellular and extracellular matrix features, expanding opportunities for studies of early neoplastic events near this critical interface and potentially leading to development of new approaches for detecting neoplasia in vivo Cancer Res; 76(16); 4637-47. ©2016 AACR.
Virus of Avian Myeloblastosis. XIII. Antibody and Immune Response of the Chicken to Formolized Virus and to Active Virus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Alfred M. Wallbank, Dorothy Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1959)

Studies were made on the antibody response of chickens to myeloblastosis virus inactivated with formalin, followed by administration of the untreated active agent. It was observed that the response to the formolized agent resulted in the induction of neutralizing antibodies in variable and low titer. Subsequent inoculation of active virus was followed by a greatly increased level of antibody titer in the sante birds. Essentially no response was seen in one of eight birds, and no evidence of infection was observed by examination of blood smears in any of the chickens, after active virus was given. Young chickens vaccinated by intraperitoneal inoculation of formolized myeloblastosis virus concentrate showed no decrease in susceptibility to the immunologically related erythroblastosis virus.
VACCINATION AGAINST MEASLES
Authors: A BOUE
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Age at Menarche. United States.
Authors: B MacMahon
Journal: Annals of Internal Medicine (1974)

In this report information from the Health Examination Survey is used to estimate current age at menarche (onset of menstruation) of women in the United States and to examine the data for differences in age at menarche among subsets of the population and for changes in age at menarche over time. As a major program of the National Center for Health Statistics the Health Examination Survey collects and analyzes information gathered by direct physical examinations, tests, and measurements performed on probability samples of the U.S. population. "Supplementary health and social information is also collected by means of several questionnaires. The survey is conducted as a series of separate, cross-sectional programs referred to as "cycles." Each cycle is limited to some specific segment of the U.S. population and to certain aspects of the health of that segment. During the period 1960-1970 three separate cycles have heen completed. Information from all three cycles is used in this report. In the first cycle, which focused on adults, female respondents completed a questionnaire in which they were asked whether or not their menstrual periods had begun and if so, at what age. In Cycles II and III, which dealt with 6-through 11-year-olds and 12-through 17-year-olds, respectively, information on menarche used in this report was supplied by the parents.
P-079 Impact of disease biology and stage on outcomes for oesophageal and gastric adenocarcinoma (OGA) treated with neoadjuvant chemotherapy
Authors: E. Fontana, E. Smyth, D. Cunningham, F. Morano, S. Rao, D. Watkins, W. Allum, J. Thompson, T. Waddell, S.Y. Moorcraft, C. Peckitt, N. Starling, I. Chau
Journal: Annals of Oncology (2015)
MB-109PRELIMINARY RESULTS OF COG ACNS0331: A PHASE III TRIAL OF INVOLVED FIELD RADIOTHERAPY (IFRT) AND LOW DOSE CRANIOSPINAL IRRADIATION (LD-CSI) WITH CHEMOTHERAPY IN AVERAGE RISK MEDULLOBLASTOMA: A REPORT FROM THE CHILDREN'S ONCOLOGY GROUP
Authors: Jeff Michalski, Gilbert Vezina, Peter Burger, Amar Gajjar, Ian Pollack, Thomas Merchant, TJ Fitzgerald, Timothy Booth, Nancy Tarbell, Ingrid Shieh, Chris Williams-Hughes, Yimei Li, Catherine Billups, Roger Packer, Anna Janss
Journal: Neuro-Oncology (2016)
RO-19RFQMR THERAPY IN BRAIN TUMORS IN CHILDREN AND YOUNG ADULTS
Authors: G.S. Nayar, Rajah Vijay Kumar, Anjana Nair, Meena Augustus
Journal: Neuro-Oncology (2016)

RO-19. RFQMR THERAPY IN BRAIN TUMORS IN CHILDREN AND YOUNG ADULTS G.S. Nayar1, Rajah Vijay Kumar2, Anjana Nair1, and Meena Augustus3; Any Time Medicare Services, Bengaluru, Karnataka, India; Scalenene CARD, Bengaluru, Karnataka, India; Shreis Scalene Services, Gaithersburg, MD, USA Rotational Field Quantum Magnetic Resonance (RFQMRw) Therapy (United States Patent 2007/ 0208249 A1 (19) Sep. 6, 2007) has evolved from the Magnetic Resonance Imaging technology. Highly complex electromagnetic beams in the radio frequency spectrum are precisely controlled and focused on to tissues to alter the cell membrane potential of the target tissue cells which in turn stimulates tissue growth in degenerative diseases such as Osteoarthritis with increase in cartilage thickness or triggers apoptosis (programmed cell death) and stops the growth in solid malignant tumors of tissues and organs like brain, liver, lung and others. Cell membrane potentials are created by the difference in the concentration of ions inside and outside the cell creating an electrochemical force across the membrane. Cell membrane potential helps control cell membrane permeability and downstream cellular pathways that can be “controlled”. When cancerous, sodium and water flow into the cells and K, Mg, Ca and Zn are lost from the cell interior and cell membrane potential falls. This phenomenon is altered by RFQMR, which “engineers” the membrane potential of cancer cells and induces cell death or apoptosis. The medical device to deliver RFQMR therapy, Cytotronw, is being used effectively in India and a few other countries, both for tissue regeneration and tumor destruction. The technology and protocol in management of cancer are briefly discussed with a few cases of advanced brain tumors especially in the young where safety and absence of side effects are highlighted. A few cases are discussed. Neuro-Oncology 18:iii159–iii164, 2016. doi:10.1093/neuonc/now082.19 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Neoplasms in Mice Inoculated with Cell-Free Extracts or Filtrates of Leukemic Mouse Tissues. I. Neoplasms of the Parotid and Adrenal Glands
Authors: S E STEWART
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Neoplasms in Mice Inoculated with Cell-Free Extracts or Filtrates of Leukemic Mouse Tissues. I. Neoplasms of the Parotid and Adrenal Glands Get access Sarah E. Stewart Sarah E. Stewart Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 5, April 1955, Pages 1391–1415, https://doi.org/10.1093/jnci/15.5.1391 Published: 01 April 1955 Article history Received: 29 October 1954 Published: 01 April 1955