tbuckley/cabot-search huggingface dataset:
Nutrition/Coeliac/Small bowel free papers 063-076
Authors: S Parry, J Barton, M Welfare, I Mohammed, L Cherkas, S Riley, T Spector, N Trudgill, S Lal, J Mclaughlin, G Giampaolo, G Dockray, A Varro, D Thompson, J Jones, D Kendall, P Millns, C Hawkey, S Dunlop, D Jenkins, R Spiller, L Gregory, L Yaguez, S Coen, E Amaro, S Smale, A Hobson, S Williams, Q Aziz, V Chudleigh, E Brennan, S Tarry, S Myers, S Lewis, G Smith, K Palmer, Z Khan, E Simpson, A Cole, I Macdonald, D Pye, A Austin, J Freeman
Journal: Gut (2002)

Introduction: Previous studies, many uncontrolled, suggest 4 to 32% of people develop irritable bowel syndrome (IBS) after ID.Little information is available on the development of other FGIDs after ID.Aim: To determine if patients with stool culture confirmed bacterial diarrhoea were more likely to develop gut symptoms consistent with a diagnosis of IBS, functional dyspepsia or functional diarrhoea at 3 and 6 month follow up compared with community controls.Methods: A prospective community-based case-control study over one year.Subjects with stool positive bacterial infectious diarrhoea and control subjects from the same primary care practice were invited to participate.The presence or not of IBS, functional dyspepsia or functional diarrhoea was diagnosed at the start and at follow up using self-complete Rome II modular questionnaires.The diagnosis of a baseline FGID excluded subjects from continuing.There were 128 cases and 219 community controls eligible and who consented to participate.Results: At follow up there was a higher incidence of FGIDs in the cases compared with controls, mainly due to a higher incidence of IBS (see table ).There was no difference in the incidence of functional dyspepsia between cases and controls.Conclusions: IBS and functional diarrhoea is diagnosed more frequently in people at three and six-month follow up after an episode of stool positive bacterial diarrhoea compared with community controls despite careful exclusion of people with pre-existing FGIDS and adds further support for the concept of post-infectious IBS.
Primary Care Doctors Are First Defense Against Cancer
Authors: J. Waalen
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Primary Care Doctors Are First Defense Against Cancer Get access Jilt Waalen Jilt Waalen Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Pages 1473–1474, https://doi.org/10.1093/jnci/84.19.1473-a Published: 07 October 1992
TCT-195 Transradial Approach for Coronary Chronic Total Occlusion Interventions: Insights from a Contemporary Multicenter Registry
Authors: Khaldoon Alaswad, Rohan V. Menon, Georgios Christopoulos, William Lombardi, Dimitri Karmpaliotis, J. Aaron Grantham, Steven Marso, R. Michael Wyman, Nagendra R. Pokala, Siddharth M. Patel, Anna Kotsia, Bavana V. Rangan, Nicholas Lembo, David Kandzari, James Lee, Kalynych Anna, Harold Carlson, Santiago Garcia, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2014)
Case 39-1991
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, R.L. Kradin, E.J. Mark
Journal: New England Journal of Medicine (1991)

Presentation of CaseA 46-year-old man was admitted to the hospital because of a cough, fever, and bilateral pulmonary nodular lesions.The patient was a native of Puerto Rico and an executive in a construction company. He was in excellent health until two months earlier, when he became involved in the supervision of a project that required the demolition of slum dwellings and latrines and the moving of earth. A dry cough and headache soon developed and resolved after one week. One month before admission the patient began his vacation by flying to New York City, where he embarked on . . .
1264 ESTROGEN DEFICIENCY AND LIPOPOLYSACCHARIDE PLAY ROLES IN THE PATHOGENESIS OF NON-ALCOHOLIC STEATOHEPATITIS (NASH)
Authors: A. Takahashi, K. Okai, F. Katsushima, K. Monoe, Y. Kanno, H. Saito, K. Abe, H. Ohira
Journal: Journal of Hepatology (2012)
P15.09 * THE EXPERIENCE OF WORK ENVIRONMENT OF PEOPLE WITH MENTAL FATIGUE AFTER BRAIN TUMOUR
Authors: L. Nordstrom, S. Hylin, G. Stragliotto
Journal: Neuro-Oncology (2014)

INTRODUCTION: Mental fatigue may occur after brain tumor and may involve a feeling of constant fatigue. The persistence of visual and motor activities can provide a focal fatigue. Mental fatigue makes it hard to have full work capacity. There are not many studies about mental fatigue that are related to work environment and brain tumour. PURPOSE: The aim was to describe how people with brain tumors and who are affected by mental fatigue experience the work environment and how it affects their ability to work, and what the participants perceive as barriers and support in the work environment. METHOD: The six participants were interviewed with the Work Environment Impact Scale (WEIS). The interview data were processed using a qualitative thematic analysis. RESULTS: The study showed that flexibility in being able to control their working hours, breaks and tasks perceived as a support for the participants. The mental fatigue that participants felt had affected their ability to cope with stress such as difficulty to perform the tasks as quickly and as long as they handle before. Working tasks that put high demands on concentration was a barrier for the participants that led to increase of mental fatigue. Workplace design and noise experienced most of the participants had an impact on how they managed to carry out their duties. Noise perceived as a typically distractions and led to the participants' mental fatigue increased. The majority of participants felt that they did not have much energy left after working out, which affected their leisure and privacy. CONCLUSIONS: The aspect of time is an aid if there is a flexibility regarding breaks, arrangement of working hours and tasks. Stressful work environment is a barrier and it is found necessary to reduce the stress of dealing with the impact of mental fatigue. Noise is a barrier and the participants felt that an aid was to reduce noise and also staying in place without many activities. The participants felt that work increased mental fatigue and affected their privacy and leisure.
Release of Prostaglandin D<sub>2</sub>into Human Airways during Acute Antigen Challenge
Authors: John J. Murray, André Bernard Tonnel, Alan R. Brash, L.Jackson Roberts, Phillippe Gosset, Robert Workman, André Capron, John A. Oates
Journal: New England Journal of Medicine (1986)

Among the many possible mediators of the early asthmatic response, prostaglandin D2, a bronchoconstrictor, is the principal cyclooxygenase metabolite of arachidonic acid that is released upon the activation of mast cells and is also synthesized by human alveolar macrophages. We performed bronchoalveolar lavage in five patients with chronic stable asthma, before and up to nine minutes after local provocative challenge with Dermatophagoides pteronyssinus. The lavage fluid was analyzed for products of arachidonic acid metabolism. Prostaglandin D2 levels in all five patients rose an average of 150-fold, from less than 8 to 332 +/- 114 pg per milliliter (mean +/- SEM; P less than 0.050), after local instillation of the antigen. Levels of 15-hydroxyeicosatetraenoic acid, which may also have a role in the pulmonary allergic response, were detectable in lavage fluid before challenge and increased after provocation with the antigen in four of the five patients. The activity of beta-glucuronidase, an enzyme released by macrophages and mast cells upon stimulation, tended to increase in the lavage fluid after provocation in all patients. These studies provide evidence that the release of prostaglandin D2 into the airways is an early event after the instillation of D. pteronyssinus in patients who are sensitive to this antigen.
A fifth of lung cancers detected by low dose CT screening are likely to be indolent, study says
Authors: M. McCarthy
Journal: BMJ (2013)

More than 18% of lung cancers detected by low dose computer tomography screening are likely to be indolent and may be cases of overdiagnosis, concludes an analysis of data from the US National Lung Screening Trial (NLST).1

In that trial 53 452 smokers and former smokers at high risk of lung cancer were randomly assigned to be screened annually for three years either with low dose computed tomography or single view posterior-anterior chest radiography then followed for an additional five years.

The study’s results, published in the …
Dissection sous-muqueuse endoscopique versus résection muqueuse endoscopique de larges lésions colorectales
Authors: D Coumaros, F Vincent
Journal: Endoscopy (2012)

Le but de ce travail était de comparer l'efficacité de la dissection sous-muqueuse endoscopique (DSME) et de la résection muqueuse endoscopique (RME) pour des résections ≥20mm de lésions colorectales.
SP0028 Adults with lupus nephritis
Authors: D. Jayne
Journal: Annals of the Rheumatic Diseases (2013)

Lupus nephritis is the most common severe manifestation of SLE and is associated with increased mortality, chronic kidney disease and end stage renal failure. Outcomes are improved by early diagnosis and institution of effective therapy. A high index of suspicion is required for early indications of renal disease in all lupus patients and renal biopsy remains the definitive diagnostic procedure. Current histological classification focuses on glomerular pathology but vascular and tubulo-interstitial disease, and the effects of secondary anti-phospholipid syndrome should also be considered. The goals of therapy are to achieve renal response (50% reduction in proteinuria) then renal remission (proteinuria &lt;0.5g/24hr, with normal glomerular filtration rate), and to prevent renal relapse (doubling of proteinuria, or haematuria with falling GFR). Early normalisation of low complement levels and falls in proteinuria are predictive of renal response at six months. Achievement of a renal response is predictive both of subsequent renal remission and of long term stability of renal function. Rates of renal remission are low, around 20%, at six months, but rise to 60-70% by two years. There is good consensus that initial therapy should combine high dose glucocorticoids with either a mycophenolic acid agent (MPA) or cyclophosphamide (CYC). Once a response is achieved, relapse is prevented by long term treatment with MPA, or azathioprine, and low dose glucocorticoids. The optimal duration of treatment is uncertain but probably several years. Regular monitoring of SLE, renal and serological variables is required along with strategies to minimise treatment related toxicity, such as fertility preservation. Urinary abnormalities do not correlate well with histological changes, especially after the onset of therapy, and there is a role for repeat renal biopsy for the assessment of changes in activity and chronicity, to detect new patterns of inflammation and for prognosis. Progressive disease after institution of therapy or failure to achieve a renal response indicates refractory disease and is managed with high dose glucocorticoids and either switching of MPA to CYC, or <i>vice versa</i>, or the introduction of rituximab. Plasma exchange may have a role in rapidly progressive disease. Management of patients with lupus nephritis should take place in centres with experience of the multi-system manifestations of SLE, of the various patterns of lupus nephritis, and of the range of medications employed in its treatment. Patient education and adherence are key factors in achieving optimal results. <h3>Disclosure of Interest</h3> D. Jayne Grant/Research support from: Roche/Genentech, Consultant for: BIOGEN, GSK, Merck Serono, Roche/Genentech
Re: Estrogen Metabolism and Excretion in Oriental and Caucasian Women
Authors: H. LEON BRADLOW, JACK FISHMAN, NITIN T. TELANG, MICHAEL P. OSBORNE
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Re: Estrogen Metabolism and Excretion in Oriental and Caucasian Women Get access H. LEON BRADLOW, H. LEON BRADLOW Search for other works by this author on: Oxford Academic PubMed Google Scholar JACK FISHMAN, JACK FISHMAN Search for other works by this author on: Oxford Academic PubMed Google Scholar NITIN T. TELANG, NITIN T. TELANG Search for other works by this author on: Oxford Academic PubMed Google Scholar MICHAEL P. OSBORNE MICHAEL P. OSBORNE Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1643–1644, https://doi.org/10.1093/jnci/86.21.1643 Published: 02 November 1994
Abstract 820: The synthetic triterpenoids, CDDO-methyl ester and CDDO-ethyl amide, and the histone deacetylase inhibitor vorinostat delay carcinogenesis in a transgenic model of estrogen receptor-negative breast cancer
Authors: Kim M. Tran, Michael B. Sporn, Karen Liby
Journal: Cancer Research (2011)

Abstract The incidence of estrogen receptor (ER)-positive breast cancer has declined over the last several years; however, there has been no change in the incidence of ER-negative breast cancer. Novel drugs and drug combinations are needed for the chemoprevention of ER-negative breast cancer. We show that the methyl ester or ethyl amide derivatives of the synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-ME and CDDO-EA, respectively) and the histone deacetylase inhibitor Vorinostat (suberoylanilide hydroxamic acid (SAHA)) delay the formation of ER-negative mammary tumors in MMTV-Polyoma Middle T (PyMT) mice. Female PyMT mice were fed control diet, CDDO-ME (50mg/kg diet), CDDO-EA (400mg/kg diet), and SAHA (250mg/kg diet), or the combinations of each triterpenoid and SAHA, beginning at 4 weeks of age. To detect initial tumor development, mice were palpated twice a week. CDDO-ME, CDDO-EA, and SAHA each significantly delayed the development of ER-negative tumors, by an average of 4.3 weeks (p &amp;lt; 0.001), 1.2 weeks (p &amp;lt; 0.05), and 2 weeks (p &amp;lt; 0.001), respectively, compared to the control group. The combination of either CDDO-ME or CDDO-EA with SAHA was significantly more potent than the individual drugs at delaying tumor development, with an average of a 5.75 (p &amp;lt; 0.001) and 5.83 (p &amp;lt; 0.001) week delay, respectively, compared with the control group. Additionally, CDDO-ME and SAHA significantly improved survival, with an average improvement of 5.2 weeks (p &amp;lt; 0.001) and 1.5 weeks (p &amp;lt; 0.05), respectively, compared to the control group. As a single agent, CDDO-EA had no significant effect on survival; however, current studies suggest that the combination of CDDO-EA and SAHA may synergistically improve survival in PyMT mice. To elucidate the mechanisms responsible for tumor delay and improvement in survival, primary epithelial cells were isolated from mammary tumors of female PyMT mice. Treatment with CDDO-ME at nanomolar concentrations resulted in a significant repression of the biomarker cyclin D1 and the induction of the cell cycle regulator p21 at the protein level. Current studies are investigating additional mechanisms of action of CDDO-ME, CDDO-EA, and SAHA and will be presented. This study shows that as single agents, CDDO-ME, CDDO-EA, and SAHA delay ER-negative mammary tumorigenesis and also synergize when used in combination for prevention. This work was supported by the Breast Cancer Research Foundation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 820. doi:10.1158/1538-7445.AM2011-820
Abstract 5486: Reliability of biomarkers of inflammation from repeated measures in healthy individuals
Authors: Sandi L. Navarro, Theodore M. Brasky, Xiaoling Song, C.Y. Wang, Alan R. Kristal, Mario Kratz, Emily White, Johanna W. Lampe
Journal: Cancer Research (2012)

Abstract Biomarkers of low-grade systemic inflammation are used to study the associations of inflammation with chronic diseases, including cancers. However, little is known about the reliability (i.e., intraindividual variability) of most of these measures. Fasting (12-hour) serum samples, which were collected at the end of ≥3 week washout periods in a 4-diet crossover feeding trial, were used to measure the inflammatory markers hsCRP, IL-6, TNF-α, IL-8 and sTNFRI and II. Participants included 32 men and 31 women (5 men and 2 women were missing from analyses of IL-8, TNF-α, and sTNFR I and II), aged 20-40, who were free of factors known to influence inflammation, e.g., chronic disease, medication use, heavy alcohol use, smoking and obesity (body mass index &amp;gt;30 kg/m2). Intraclass correlations (ICC) were estimated using random effects analysis of variance, across all 4 time points (∼5 weeks apart). For TNF-α and sTNFRI &amp; II, the ICCs were very high (ICC= 0.92, 95% CI: 0.89 - 0.96; 0.92, 95% CI: 0.88 - 0.95; and 0.90, 95% CI: 0.85 - 0.94, respectively). The ICCs for IL-8 and hsCRP were 0.73 (95% CI: 0.63-0.83 and 0.68 (95% CI: 0.58-0.78), respectively. The ICC for IL-6 was considerably lower, (ICC = 0.48, 95% CI: 0.36-0.62). With the exception of IL-6, reliability of all inflammatory markers in our panel over 4 time points was high, suggesting that a single measure accurately captures the variability within an individual and is a good measure for use in epidemiologic studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5486. doi:1538-7445.AM2012-5486
Application of Endoscopic Ultrasonography to Detect Lymph Node Metastasis in Gastric Cancer
Authors: Shan Hongbo, Li Yin, Luo Guangyu, Zhang Rong, Gao Xiaoyan, Li Jianjun, Xu Guoliang
Journal: Endoscopy (2011)

Objective: To evaluate the application of endoscopic ultrasonography (EUS) to detect lymph node metastasis in gastric cancer.
Evaluation of risk factors for PNET and GIST based on EUS-FNA specimens
Authors: Katanuma Akio
Journal: Endoscopy (2011)

To examine whether the risk factors of pancreatic neuroendocrine tumor (PNET) and gastrointestinal stromal tumor (GIST) could be accurately evaluated using endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) specimens
GE-05 * EXOME SEQUENCING REVEALS BRAF MUTATIONS IN PAPILLARY CRANIOPHARYNGIOMAS
Authors: P. Brastianos, A. Taylor-Weiner, P. Manley, R. Jones, D. Dias-Santagata, A. Thorner, F. Rodriguez, L. Bernardo, L. Schubert, C. Stewart, M. Kieran, D. Louis, G. Getz, S. Santagata
Journal: Neuro-Oncology (2014)

Craniopharyngiomas are epithelial tumors that typically arise in the suprasellar region of the brain. Patients experience substantial clinical sequelae both from extension of the tumors and from therapeutic interventions which damage the optic chiasm, the pituitary stalk, and the hypothalamic area. Using whole exome sequencing we identified mutations in beta-catenin (CTNNB1) in nearly all adamantinomatous craniopharyngiomas (11/12; 92%) and recurrent mutations in BRAF (V600E) in all papillary craniopharyngiomas (3/3; 100%). Targeted genotyping revealed BRAF V600E in 95% of papillary craniopharyngiomas (36 of 39 tumors) and CTNNB1 mutation in 96% of adamantinomatous craniopharyngiomas (51 of 53 tumors). The CTNNB1 and BRAF mutations were clonal in each tumor subtype and no other recurrent mutations or genomic aberrations were detected in either subtype. Adamantinomatous and papillary craniopharyngiomas harbor mutations that are mutually exclusive and clonal. These findings have important implications for the diagnosis and treatment of these neoplasms.
Streptococcal Pneumonia and Empyema in Childhood
Authors: Sherwin V. Kevy, Betty Ann Lowe
Journal: New England Journal of Medicine (1961)

THE importance of Staphylococcus aureus as the etiologic agent in pneumonia complicated by empyema has been emphasized in many recent reviews.1 , 2 The problem of pneumonia and empyema secondary to streptococcal infection has been ignored since the advent of the antibiotic era. In view of the increasing incidence of streptococcal infection and its complications throughout the country,3 it is of interest to review recent experience with pneumonia due to the hemolytic streptococcus and to re-emphasize the clinical course and management of this disease in the pediatric age group.During the twelve-month period from June, 1958, to June, 1959, 93 cases of . . .
Granulopoiesis in Acute Myeloid Leukemia and Preleukemia
Authors: Peter L. Greenberg, William C. Nichols, Stanley L. Schrier
Journal: New England Journal of Medicine (1971)

Abstract In vitro regulation of granulocytic proliferation and differentiation was analyzed by study of marrow granulocytic colony-forming capacity (CFC) and peripheral white-cell provision of colony-stimulating activity (CSA) in patients with acute myeloid leukemia (AML) and preleukemia. Patients with AML in relapse had abnormal marrow CFC, producing either no or excessive numbers of abortive colonies. Furthermore, their leukocytes lacked ability to provide CSA. During complete remission, both these indexes were normal. Sequential studies indicated that marrow CFC correlates with, and probably precedes, detectable changes in clinical and morphologic status. Preleukemic patients showed disordered CFC and CSA, with values similar to those in AML in relapse. AML marrow appears to consist of coexisting normal and leukemic cell clones, and preleukemic marrow to contain either a potentially leukemic clone with greater capacity for differentiation in vivo or a leukemic clone that is held in abeyance.
NECROSECTOMIA ENDOSCÓPICA POR IRRIGACIÓN A TRAVÉS DE PRÓTESIS DE APOSICIÓN LUMINAL EN NECROSIS PANCREÁTICAS ENCAPSULADAS (WOPN): EXPERIENCIA PRELIMINAR
Authors: JB Gornals, C Consiglieri, S Salord, L Secanella, S Redondo, C Pons, J Busquets, N Pelaez, J Fabregat
Journal: Endoscopy (2014)

Introducción: la necrosectomia endoscópica de las necrosis pancreáticas encapsuladas (WOPN) derivada de las pancreatitis necrotizantes es una alternativa a la cirugía o drenaje percutáneo. Técnica no estandarizada y con dudas sobre su metodología: mecánica con utensilios, irrigación, nasoquístico o mixto.
Ga-67 Visualizing Metastases of Malignant Melanoma to Gastric Cancer
Authors: MITSUTAKA FUKUMOTO, NAOKO YOSHIMURA, ATSUSHI KUROHARA, SHOJI YOSHIDA
Journal: Clinical Nuclear Medicine (1997)

Metastases of one cancer to another coexisting neoplasm, whether it is malignant or not, in the same individual is extremely rare. Fewer than 100 cases have been described in the literature; the most frequent combination of this metastatic pattern has been bronchogenic carcinoma metastasizing to renal cell carcinoma. To the authors' knowledge, no case of malignant melanoma metastasizing to the inside of a gastric cancer lesion has been published. In our present case, it might be appropriate to think that an enlarged gastric cancer may have accounted for the avid accumulation of Ga-67. Nevertheless, the strongly speckled accumulation observed in the epigastrium may represent metastatic foci of the melanoma within the gastric cancer.
928 WHICH ELASTOGRAPHIC METHOD (TRANSIENT ELASTOGRAPHY OR ARFI) IS BETTER CORRELATED WITH LIVER FIBROSIS IN PATIENTS WITH CHRONIC HEPATITIS C - AN INTERNATIONAL MULTICENTER STUDY
Authors: I. Sporea, S. Bota, R. Sirli, R. Badea, M. Lupsor, H. Saito, H. Ebinuma, M. Friedrich-Rust, C. Sarrazin, F. Piscaglia, A. Borghi, M. Peck-Radosavljevic, A. Ferlitsch, A. Popescu, M. Danila
Journal: Journal of Hepatology (2012)