tbuckley/cabot-search huggingface dataset:
Dystocia due to Ante-Partum Hourglass Contraction of Uterus: Caesarean Section
Authors: C. C. Weeks
Journal: BMJ (1898)

IDEC 24, iS brim, the effective force being far less than half the amount; which is used.In the axis A B there is no.loss of power, and risk of any injury to the structures over the pubic bones is reduced to a minimum.Although in its ordinary use this attachment is a tractor, it is possible with ease to lift a head over the pubic brim in pendulous abdomen (F s) and adjust it to the brim, or to the diameters of a deformed pelvis.In brief, by combined use of handle and tractor, the head can be moved into any position, and traction made in any direction with the greatest ease and precision.And whilst the lock is allowed considerable play, so that continuous pressure of the head is avoided, the force requisite for delivery is, in practice, found to be little, for it may be entirely used in the line of least resistance.If instrumental delivery is conducted with precise know- ledge of the mechanism of natural labour and of the direction of natural force-which is not downwards, but backwards into the hollow of the sacrum-and the instrument used is capable of accurately supplementing that force, and is, in its slightest movement, absolutely under the control of the operator, all difficulty disappears and with it the excuse for an undue and dangerous expenditure of force on parts which were never by Nature intended to suffer such abuse.
Purified autologous grafting in childhood acute lymphoblastic leukemia in second remission: evidence for long-term clinical and molecular remissions
Authors: A Balduzzi, G Gaipa, S Bonanomi, M Dassi, P Perseghin, F Buscemi, E D'Aniello, A Rovelli, R Schirò, D Longoni, A Rambaldi, C Uderzo, A Biondi
Journal: Leukemia (2001)
A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients Requiring Mechanical Ventilation
Authors: Deborah Cook, Gordon Guyatt, John Marshall, David Leasa, Hugh Fuller, Richard Hall, Sharon Peters, Frank Rutledge, Lauren Griffith, Allan McLellan, Gordon Wood, Ann Kirby, Martin Tweeddale, Joe Pagliarello, Richard Johnston
Journal: New England Journal of Medicine (1998)

Critically ill patients who require mechanical ventilation are at increased risk for gastrointestinal bleeding from stress ulcers. There are conflicting data on the effect of histamine H2-receptor antagonists and the cytoprotective agent sucralfate on rates of gastrointestinal bleeding, ventilator-associated pneumonia, and mortality.
AB1465-HPR The cost of hospitalisation for knee osteoarthritis in france in 2010
Authors: F. Rannou, P. Bertin, L. Grange, C. Taieb
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The cost of an osteoarthritic patient has not been estimated for several years <h3>Objectives</h3> Evaluate the cost of hospitalization of knee osteoarthritis patients in France in 2010 <h3>Methods</h3> For hospital stays (medical, surgery and obstetrics)and for patients treated under Follow-up care and Rehabilitation (formerly "halfway house"), use of the PMSI data.The evaluation we carried out is based on the last 2 years of available data - 2009 and 2010 <h3>Results</h3> In France, around 85 000 patients are treated yearly in hospital for knee osteoarthritis. They are made up of 62% women and 38% men, with an average age of 70. The average hospital stay was 9 days (9.1 average per patient per year). The average annual cost of hospital treatment for one patient is estimated at around €7700 61% of patients are then treated with rehabilitation, of which 67% are women. The average age of patients treated with rehabilitation is 71. Each patient stayed for an average of 35 days, either full or partial hospitalization with functional reeducation or medical follow-up treatment. The annual treatment cost of a patient in rehabilitation is estimated at €6986. In total, the average annual cost for all patients treated in hospital (medical/surgery/obstetrics + rehabilitation) for knee osteoarthritis in 2010 is estimated at €11961. In total, the overall annual cost of one patient treated in hospital (medical/surgery/obstetrics + rehabilitation) for knee osteoarthritis in 2010 is estimated at €1322 million euros. <h3>Conclusions</h3> The last study evaluating the cost of osteoarthritis in France reported 127 000 short-stay admissions, 175 000 follow-up and/or rehabilitation treatment days, and 118 000 knee or hip replacements, the overall cost of hospitalizations is therefore 820 million euros in 2002. Our evaluation demonstrates that this cost evaluation is outdated, as the amount is lower than the overall cost of hospitalizations linked to osteoarthritis of the knee. <h3>References</h3> COART - Le Pen and coll, Revue du rhumatisme, December 2005 <h3>Disclosure of Interest</h3> F. Rannou: None Declared, P. Bertin: None Declared, L. Grange: None Declared, C. Taieb Employee of: PFSA
P84 Utility Values For COPD Patients Based on the EQ-5D Questionnaire from Three Indacaterol Phase III Studies
Authors: Y Asukai, M Baldwin, L Mungapen
Journal: Thorax (2012)

<h3>Introduction and Objectives</h3> Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitation that is not fully reversible and disabling symptoms such as breathlessness and COPD exacerbations, which have a negative impact on health-related quality of life (HRQoL). The indacaterol clinical trial programme (INVOLVE, INHANCE and INLIGHT-2 trials) collected HRQoL using the EuroQoL (EQ-5D) instrument, a commonly used tool to generate preference-based utilities involving five dimensions of a health state. As part of the clinical trial programme, the EQ-5D scores were converted to a utility index score using the UK National Health Survey (1) preference weights. The aim of this analysis was to report mean utilities of COPD patients by disease severity. <h3>Methods</h3> A total of 11,066 observations from three trials were included in the analysis. Utility index scores were summarised by disease severity (GOLD 2008 FEV1-based) to yield a mean utility weight for each disease severity class. Disease severity was determined by using all available FEV1 readings. Since some trials had a longer duration contributing more records of EQ-5D and spirometry than others, it was necessary to correct for multiple observations; utility values that might have been derived from the shorter-duration trials were considered as ‘missing’ data. To impute missing data, a mixed effects model was used using residual maximum likelihood. Clinic visit and disease severity were included as factors. Utility values were assumed to be missing at random. <h3>Results</h3> The estimated utility of COPD patients according to levels of disease severity was as follows: Mild = 0.820 (95% CI: 0.800– 0.840); Moderate = 0.801 (95%CI: 0.794–0.809); Severe = 0.774 (95% CI: 0.767–0.782); and Very Severe = 0.743 (95% CI: 0.730–0.756). The correlation between increasing disease severity and decreasing patients’ utility demonstrated the internal validity of the data. <h3>Conclusion</h3> This analysis provides estimates of utility by COPD disease severity based on one of the largest sample sizes used to date, which is essential for cost-utility analyses that help inform healthcare decisions. Kind P et al. “Variations in population health status: results from a United Kingdom national questionnaire survey.” <i>BMJ</i> 316, no. 7133 (Mar 1998): 736–41.
A4.7 T and B cells participate in bone repair by infiltrating the fracture callus in a two-wave fashion
Authors: A Serra, I Könnecke, T El Khassawna, C Schlundt, H Schell, A Hauser, A Ellinghaus, HD Volk, A Radbruch, GN Duda, K Schmidt-Bleek
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Fracture healing is a regenerative process and is one of the two processes in the human body in which an organ is restored without scar tissue formation. The healing cascade initiates with a cycle of inflammation, cell migration, proliferation and differentiation. Immune cells invade the fracture site immediately upon bone damage and contribute to the initial phase of the healing process and appear to recruit accessory cells to the injury site. However, little is known about the role of the immune system in the later stages of fracture repair, in particular, whether lymphocytes participate in soft and hard callus formation. <h3>Materials and methods</h3> In order to answer this question, we analysed femoral fracture healing in mice by confocal microscopy, flow cytometry and molecular biology. <h3>Results</h3> Upon fracture, we could detect generalised increased frequencies of T cells in the bone marrow of injured mice which persisted throughout healing. By closely analysing the fractured bone, we found that surprisingly, after the initial inflammatory phase, when soft callus developed, T and B cells withdrew from the fracture site. Thereafter lymphocytes massively infiltrated the callus region (around day 14 after injury), during callus mineralisation. Interestingly, lymphocytes were not found within cartilaginous areas of the callus but only nearby newly forming bone. During healing, B cell numbers seemed to exceed those of T cells and B cells progressively underwent effector maturation associated with high OPG production capacity. During bone regeneration, both osteoblasts and osteoclasts were found to undergo direct cell-cell contact with lymphocytes. The latter were also found to secrete OPG in the callus and their appearance also correlated with a progressive increase in the ratio of OPG vs. RANKL gene expression during fracture repair. <h3>Conclusions</h3> Our data strongly suggests a regulatory role of T and B cells not only in the initial phase of healing but specifically also in the later stages of fracture remodelling.
Razors and Refrigerators and Reindeer — Oh My!
Authors: Susan Jenks, Nancy Volkers
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Razors and Refrigerators and Reindeer — Oh My! Get access Susan Jenks, Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 24, 16 December 1992, Page 1863, https://doi.org/10.1093/jnci/84.24.1863 Published: 16 December 1992
Stat Bite: NCI Annual Budget in Current and Real Dollars
Authors: M. Brown
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Stat Bite: NCI Annual Budget in Current and Real Dollars Get access Martin Brown, Ph.D Martin Brown, Ph.D Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 16, 21 August 1991, Page 1129, https://doi.org/10.1093/jnci/83.16.1129 Published: 21 August 1991
THE CLINICAL FEATURES AND UNDERLYING PATHOPHYSIOLOGY OF MYOCARDIAL INFARCTION WITH NO OBSTRUCTIVE CORONARY ATHEROSCLEROSIS: THE ROLE OF OPTICAL COHERENCE TOMOGRAPHY
Authors: Tatsunori Takahashi, Hideki Okayama, Go Kawamura, Tatsuya Shigematsu, Masaki Kinoshita, Yoshitaka Kawada, Go Hiasa, Tadakatsu Yamada, Yukio Kazatani
Journal: Journal of the American College of Cardiology (2016)
Abstract 728: CXCL12 (SDF-1) chemokine expression as a baseline factor associated with resistance to induction chemotherapy in head and neck squamous cell carcinoma
Authors: Caroline Halimi, Sébastien Albert, Annemilai Tijeras-Raballand, Lucile Astorgues-Xerri, Anne Couvelard, Muriel Hourseau, Maria Eugenia Riveiro, Maria Serova, Eric Raymond, Sandrine J. Faivre
Journal: Cancer Research (2012)

Abstract Background. SDF-1, and its cognate receptor CXCR4, are recognized as major factors in tumor progression and metastasis. Recent data also suggest that chemokines may play a role in resistance to chemotherapy. In this study, we investigated the expression of SDF-1 and CXCR4 in initial tumor biopsies prior to treatment in patients treated by induction chemotherapy for organ preservation and correlated this expression with response to chemotherapy. Material and Methods. Patients with locally advanced pharyngo-laryngeal carcinomas, candidates for neoadjuvant platinum-based chemotherapy as part of an organ preservation program, were considered for this study. Objective response in organ preservation accounted for more than 50% reduction in tumor size on CT-scan or MRI. Tissue biopsies were scored for SDF-1, CXCR4, Vimentin and E-cadherin staining by immunohistochemistry. Staining was measured according to a specific scoring scale. Biopsies were all read by three different observers for scoring adjudication and quantification was performed using the Histolab Software (Microvision). Results. Among the 42 patients who entered in this study, 23 had primary site in the hypopharynx and 19 in the larynx. Twenty-two patients experienced objective response and 20 patients were non-responders to induction chemotherapy. SDF-1 staining score was higher in cancer cells than that in normal epithelial cells located in the close vicinity of the tumor. SDF-1 staining was predominantly located in the cytoplasm of cancer cells. The level of SDF-1 expression was significantly higher in tumors from non-responders compared to responders (score: 155 vs 110, p=0.01). CXCR4 expression was similar between responders and non-responders, and predominantly located in the cytoplasm and the nucleus of cancer cells. Vimentin and E-cadherin were evaluated as potential differentiation markers. Few tumor cells expressed Vimentin in our biopsies. Interestingly lower E-cadherin expression was observed in non-responders compared to responders (score: 110 vs 170, p=0.01) suggesting that loss in epithelial differentiation may facilitate resistance to chemotherapy in this population. Conclusion. High expression levels of SDF-1 cytokine and the loss of E-cadherin as a marker of epithelial differentiation in cancer cells were shown to correlate with the lack of response to induction chemotherapy in hypopharyngeal and laryngeal squamous cell carcinomas. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 728. doi:1538-7445.AM2012-728
Workplace Breast Cancer Screening Signals Shift in Corporate Culture
Authors: F. X. Mahaney
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Workplace Breast Cancer Screening Signals Shift in Corporate Culture Get access Francis X. Mahaney, Jr Francis X. Mahaney, Jr Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 10, 18 May 1994, Pages 746–747, https://doi.org/10.1093/jnci/86.10.746 Published: 18 May 1994
A newly designed plastic stent for multiple occluded metallic stents deployed in malignant hilar biliary strictures
Authors: H. Kato, H. Kawamoto, K. Yamamoto, Y. Noma, T. Sonoyama, K. Tsutsumi, M. Fujii, N. Kurihara, H. Okada
Journal: Endoscopy (2011)

The feasibility and safety of endoscopic deployment of multiple metallic stents in malignant hilar biliary strictures have been addressed in several articles [1] [2] [3] [4] [5]. However, once metallic stents are occluded, multiple deployment of plastic stents through the previously deployed metallic stents is sometimes difficult. We have designed a new plastic stent for dealing with multiple metallic stent occlusion, and report a successful case using this new stent.
Abstract 2436: Endothelial integrin α3β1 stabilizes TF antigen/Galectin-3 mediated metastatic cell adhesion to the endothelium
Authors: Olga V. Glinskii, Feng Li, Kate Rittenhouse-Olson, Joseph Barchi, Vladislav V. Glinsky
Journal: Cancer Research (2011)

Abstract Metastatic cell arrest in distant organ microvessels constitutes an essential rate-limiting step in hematogenous cancer metastasis. Previously, in a series of works we demonstrated the importance of interactions between cancer-associated Thomsen-Friedenreich antigen (TF-Ag) and endothelial galectin-3 (Gal-3) in facilitating the initial carbohydrate-mediated tumor cell adhesion to distant organ microvasculature. However, it was unclear which molecules stabilize TF-Ag/Gal-3 mediated adhesion and how these interactions effect subsequent events in a metastatic cascade. Here, the results of a pull down assay using TF-Ag coated gold nanoparticles followed by Western analysis identified endothelial integrin α3β1 being physically associated with TF-Ag/Gal-3 complexes. Blocking α3β1 did not affect the initial tumor cell adhesion to the endothelium, but reduced &amp;gt;10-fold shear force necessary to displace cancer cells stably attached to endothelial monolayers, indicating that α3β1 stabilizes tumor-endothelial cell adhesion initiated by TF-Ag/Gal-3 interactions. Subsequent Quadrupole Time-of-Flight mass spectrometry analysis revealed additional 7 proteins forming a macromolecular complexes with TF-Ag, Gal-3 and α3β1 such as filamin B, talin, IQ motif containing GTPase activating protein 1, vinculin, α actinin 4, zyxin, and T-plastin, all of which map onto focal adhesion pathway. Our data demonstrate an induction of complex signaling pathways downstream of this macromolecular complex facilitating endothelial cell retraction and metastatic cell transendothelial migration. Thus, endothelial α3β1 mobilization downstream of TF-Ag/Gal-3 interactions stabilizes tumor-endothelial cell adhesion, initiates focal adhesion formation, and induces signaling pathways in endothelial cells promoting cancer metastasis. This work was supported in part by Award Number 1I01BX000609 from the Biomedical Laboratory Research &amp; Development Service of the VA Office of Research and Development to VVG and AHA National SDG 0830287N to OVG. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2436. doi:10.1158/1538-7445.AM2011-2436
TREATMENT WITH ANTI-IL12/23 AGENTS IMPROVES FETUIN AND OXIDATIVE STRESS IN PARALLEL WITH ENDOTHELIAL GLYCOCALYX, CORONARY FUNCTION AND MYOCARDIAL TWISTING IN PATIENTS WITH PSORIASIS
Authors: Ignatios Ikonomidis, Mary Varoudi, George Makavos, Evagelia Papadavid, Ioanna Andreadou, Kostas Gravanis, George Pavlidis, Helen Triantafyllidi, Ioannis Paraskevaidis, John Parissis, Dimitrios Rigopoulos, John Lekakis
Journal: Journal of the American College of Cardiology (2015)
Abstract 3968: Exploring cancer datasets in the integrative genomics viewer (IGV)
Authors: James T. Robinson, Helga Thorvaldsdottir, Jill Mesirov
Journal: Cancer Research (2012)

Abstract Cancer genome characterization studies, such as The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC), are producing a flood of diverse data including whole-genome sequencing scans, expression profiles, high-resolution SNP and copy number data, and epigenetic profiles. These diverse datasets are enabling researchers to study the cancer genome in unprecedented detail. However, their sheer size and diversity presents significant challenges to downstream interpretation. While much progress has been made in automated analysis, human review enabled by intuitive and responsive visualizations remains an essential component of data analysis. The Integrative Genomics Viewer (IGV) was developed to address this need by providing researchers with an intuitive, user-friendly, interactive visualization tool for exploration of diverse genomic datasets. IGV has extensive support for both next-generation and micro-array based platforms, and for integration of these data types with clinical and phenotypic data. It provides an intuitive interface similar to online mapping tools such as Google Maps, enabling smooth zooming and panning at all resolution scales, from whole genome to base pairs. Data can be annotated, filtered, grouped, and sorted in a variety of ways. This ability to dynamically and flexibly integrate multiple different datasets, and view them at any scale, allows investigators to elucidate complex biological relationships that are not otherwise readily apparent. In this presentation we describe the IGV, with emphasis on recent features focused on data integration and interpretation, developed in close collaboration with cancer researchers. Specifically (1) a multi-locus pathway view which supports simultaneous viewing of data in multiple genomic regions defined by pathways or gene sets, (2) integration with external tools such as Mutation Assessor and PolyPhen, to provide views and data to asses the functional significance of somatic events, and (3) a flexible, interactive charting capability to enable detailed exploration of inter-dependencies between data types at a specific locus or set of loci. These features will be illustrated in the context of use cases drawn from the TCGA glioblastoma multiforme and ovarian datasets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3968. doi:1538-7445.AM2012-3968