tbuckley/cabot-search huggingface dataset:
Intraperitoneal radioimmunotherapy (RIT) for desmoplastic small round cell tumor (DSRCT).
Authors: Shakeel Modak, Jorge A. Carrasquillo, Michael P. La Quaglia, Pat Zanzonico, Neeta Pandit-Taskar, Jason S. Lewis, Nai-Kong V. Cheung
Journal: Journal of Clinical Oncology (2012)

TPS9595 Background: DSRCT, a rare sarcoma of adolescents and young adults arises from serosal surfaces typically the peritoneum. It is characterized by t(11;22)(p13;q12) chromosomal translocation; and is lethal in &gt;80% of patients despite aggressive surgery and chemoradiotherapy. Disease recurrence often presents as multifocal peritoneal implants, making it uniquely suited for intraperitoneal (IP) targeting. Since DSRCT is radiosensitive, we hypothesize that improving local control with targeted radiotherapy may reduce relapse and enhance survival. IP RIT, by virtue of prolonged residence time, and slow/incomplete transfer to the circulation, may selectively target IP disease while minimizing organ toxicity. The anti-4Ig-B7H3 murine monoclonal antibody 8H9 binds to 96% of primary DSRCT with restricted reactivity to normal tissue (Med Pediatr Oncol 39:547). 131 I-8H9 targets DSRCT xenografts and has proven safe at 80mCi when injected intrathecally (J Neurooncol 97:409). 124 I-8H9, a novel positron-emitting radioimmunoconjugate is ideally suited for quantitative imaging and pharmacokinetic (PK) studies. Methods: We have initiated a phase I study to test the safety of IP RIT using 131 I-8H9 in patients with DSRCT (clinicaltrials.gov NCT01099644). Cohorts of 3-6 patients are treated with 131 I-8H9 at escalated doses from 30mCi/m 2 -60mCi/m 2 as a single IP injection. An IP tracer dose of 2mCi 124 I-8H9 is given prior to 131 I-8H9 to acquire high-resolution PET images and data on 8H9 tumor targeting and biodistribution. PK is also studied using serial blood draws. Patients are monitored for toxicity clinically and biochemically. Response to treatment is assessed using RECIST criteria and via a follow up 124 I-8H9 PET scan if tumor targeting is noted on initial imaging. Hematopoietic stem cells are harvested a priori to reverse myelosuppression if any. Three cohorts of patients (n=9) up to 50mCi/m 2 have completed therapy thus far without dose-limiting toxicity or myelosuppression. This is the first study of IP RIT in pediatrics, and the first to use PET for IP RIT. Data obtained will be critical in establishing safety of IP 131 I-8H9 in children and young adults, and in designing phase II trials to study efficacy of IP RIT for DSRCT.
Histologic transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma
Authors: Rose Lou Marie C. Agbay, Nitin Jain, Sanam Loghavi, L. Jeffrey Medeiros, Joseph D. Khoury
Journal: American Journal of Hematology (2016)

Although generally considered a clinically indolent neoplasm, CLL/SLL may undergo transformation to a clinically aggressive lymphoma. The most common form of transformation, to DLBCL, is also known as Richter syndrome. Transformation determines the course of the disease and is associated with unfavorable patient outcome. Precise detection of transformation and identification of predictive biomarkers and specific molecular pathways implicated in the pathobiology of transformation in CLL/SLL will enable personalized therapeutic approach and provide potential avenues for improving the clinical outcome of patients. In this review, we present an overview of the pathologic features, risk factors, and pathogenic mechanisms of CLL/SLL transformation. Am. J. Hematol. 91:1036-1043, 2016. © 2016 Wiley Periodicals, Inc.
Case 39-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Zareh N. Demirjian, John C. Long
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 24-year-old woman was admitted to the hospital because of a bleeding disorder.The patient was in vigorous health. Six days before admission she donated 1 unit of blood. On the same day a normal menstrual period began. On the evening before entry she noticed oozing of blood from her gums while brushing her teeth. On the next day epistaxis occurred, and she came to the hospital.She had had infectious mononucleosis six years earlier. A cousin had diabetes mellitus; a maternal aunt and a maternal cousin had sarcoidosis. There was no family history of connective-tissue disease, . . .
Haiti’s health system collapsing under weight of doctors’ strike
Authors: Owen Dyer
Journal: BMJ (2016)

In Haiti a medical residents’ strike, hospital closures, and a lack of basic medical supplies have left millions of patients with no realistic treatment options.

Most of the country’s public teaching hospitals have shut down and many staff are downing tools in sympathy with the striking residents, who earn just 7000 Haitian gourdes a month (£85; €100; $111) at the outset of residency, rising to a possible 9000 gourdes.

Among the closed hospitals is the country’s largest, Port-au-Prince’s Hospital of the State University of Haiti (HUEH), known locally as the General Hospital. Strike action began there in March when the hospital’s administrator allegedly slapped a resident during a dispute over a delayed test for a patient.

“None of the public hospitals around the country are functioning and no one is saying anything. Everyone is walking around like it’s no big deal,” HUEH’s executive director, Maurice Fils Mainville, told the Miami Herald .

The strike soon turned into a nationwide residents’ walkout, with strikers demanding pay rises, safer working conditions, …
Case 16-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Cecil H. Coggins, Robert B. Colvin
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 70-year-old man was admitted to the hospital because of edema.For 10 years he had been known to have hepatic cirrhosis, considered secondary to excessive use of alcohol; esophageal varices were never demonstrated. He had smoked three packages of cigarettes daily for many years and had a chronic cough productive of thick, white sputum. He had had mild diabetes mellitus for more than 10 years and had been treated for congestive heart failure. Six years before admission a diagnosis of pericarditis was made; he recovered without recurrence. Three months before entry he was evaluated for chronic . . .
Iron Supplementation for Chemotherapy-Induced Anemia in Patients Receiving Erythropoiesis-Stimulating Agents
Authors: Rahul Mhaskar, Benjamin Djulbegovic
Journal: JAMA Oncology (2016)

<h3>Clinical Question</h3> What are the benefits and harms of iron supplementation alone and as an adjunct to erythropoiesis-stimulating agents (ESAs) compared with ESA alone in the treatment of chemotherapy-induced anemia? <h3>Bottom Line</h3> Addition of iron to ESAs improves hematopoietic response, reduces the need for red blood cell transfusions, increases hemoglobin levels, and seems to be well tolerated. The subgroup analyses suggest the superiority of parenteral iron over oral iron supplementation in the treatment of chemotherapy-induced anemia.
Safe and Effective Use of Rivaroxaban for Treatment of Cancer-Associated Venous Thromboembolic Disease: A Quality Improvement Initiative
Authors: Simon Mantha, Yimei Miao, Debra Sarasohn, Jonathan Kessler, Rekha Parameswaran, Samantha Stefanik, Gagandeep Brar, Patrick Samedy, Jonathan Wills, Dhruvkumar Patel, Gerald A Soff
Journal: Blood (2015)
The pharmacological treatment of delusional depression
Authors: D G Spiker, J C Weiss, R S Dealy, S J Griffin, I Hanin, J F Neil, J M Perel, A J Rossi, P H Soloff
Journal: American Journal of Psychiatry (1985)

The authors investigated the pharmacological treatment of delusional depression by assigning patients on a random double-blind basis to amitriptyline alone, perphenazine alone, or a combination of the two. Fourteen (78%) of the 18 patients assigned to amitriptyline plus perphenazine were responders, compared with seven (41%) of 17 patients treated with amitriptyline alone and three (19%) of the 16 patients treated with perphenazine alone. The combination of amitriptyline and perphenazine was clearly superior (p less than .01).
Frequency of and factors associated with positive or equivocal margins in conventional excision of atypical intraepidermal melanocytic proliferations (AIMP): A single academic institution cross-sectional study
Authors: Junqian Zhang, Christopher J. Miller, Joseph F. Sobanko, Thuzar M. Shin, Jeremy R. Etzkorn
Journal: Journal of the American Academy of Dermatology (2016)
Pneumococcal conjugate, meningococcal C and varicella vaccination in Italy
Authors: F D'Ancona, V Alfonsi, M R Caporali, A Ranghiasci, M L Ciofi Degli Atti
Journal: Eurosurveillance (2007)

The 7-valent anti-pneumococcal conjugate vaccine (PCV), anti-meningococcal C-conjugate vaccine (MenC) and varicella vaccine have been recently introduced in EU. In Italy, these vaccines have so far been recommended for use in specific groups. Since the health system is decentralised, the Regional Health Authorities (RHAs) can decide to recommend vaccination for other target populations. We conducted a survey to describe the recommendations on these vaccines currently in place in the 21 Italian regions. In November 2005, a standardised questionnaire was sent to RHAs, including information on the existence of regional recommendations, vaccination target population, and whether vaccines were provided free of charge, or at a reduced cost compared to pharmacies. Information reported in the questionnaires were followed up in May 2006. All 21 regions completed and returned the questionnaire and were contacted for follow-up. Recommendations about at least one of the three vaccines were present in 20 out of 21 regions. All included free of charge PCV offering to specific groups, while MenC and varicella immunisations were recommended in 17 and 19 regions, respectively. Recommendations for other individuals varied greatly by area: free of charge PCV and MenC vaccinations targeting all infants have been recommended in nine regions, and varicella vaccination targeting children in the second year of life in three regions. These different recommendations can lead to marked variation in vaccination coverage rates observed through the country, with a consequent different level of disease control. It is thus crucial to properly monitor vaccination coverage rates for PCV, MenC and varicella, as these are not routinely collected at the national level.
PET/CT Is a Useful Tool For Both Refining The Definition Of Complete Response (CR) In Multiple Myeloma (MM) and Detecting Otherwise Unrevealed Progression During The Follow-Up Of The Disease: A Single Centre Experience On 282 Patients
Authors: Elena Zamagni, Cristina Nanni, Annalisa Pezzi, Katia Mancuso, Paola Tacchetti, Lucia Pantani, Beatrice Anna Zannetti, Annamaria Brioli, Serena Rocchi, Giulia Marzocchi, Nicoletta Testoni, Carolina Terragna, Giovanni Martinelli, Stefano Fanti, Michele Cavo
Journal: Blood (2013)
Progression sites of metastatic breast cancer under chemotherapy.
Authors: M F Fey, K W Brunner
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.2.322 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3806179 Progression sites of metastatic breast cancer under chemotherapy. M F FeyxM F FeySearch for articles by this author , K W BrunnerxK W BrunnerSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.2.322 PDF "Progression sites of metastatic breast cancer under chemotherapy.." Journal of Clinical Oncology, 5(2), pp. 322–323© 1987 by American Society of Clinical Oncology
The epidemiology of infectious syphilis in the Republic of Ireland
Authors: M Cronin, L Domegan, L Thornton, M Fitzgerald, S Hopkins, P O’Lorcain, E Creamer, D O'Flanagan
Journal: Eurosurveillance (2004)

In response to the increasing numbers of syphilis cases reported among men having sex with men (MSM) in Dublin, an Outbreak Control Team (OCT) was set up in late 2000. The outbreak peaked in 2001 and had largely ceased by late 2003. An enhanced syphilis surveillance system was introduced to capture data from January 2000. Between January 2000 and December 2003, 547 cases of infectious syphilis were notified in Ireland (415 were MSM). Four per cent of cases were diagnosed with HIV and 15.4% of cases were diagnosed with at least one other STI (excluding HIV) within the previous 3 months. The mean number of contacts reported by male cases in the 3 months prior to diagnosis was 4 (range 0-8) for bisexual contacts and 6 for homosexual contacts (range 1-90). Thirty one per cent of MSM reported having had recent unprotected oral sex and 15.9% of MSM reported having had recent unprotected anal sex. Sixteen per cent of cases reported having had sex abroad in the three months prior to diagnosis. The results suggest that risky sexual behaviour contributed to the onward transmission of infection in Dublin. The outbreak in Dublin could be seen as part of a European-wide outbreak of syphilis. The rates of co-infection with HIV and syphilis in Ireland are comparable with rates reported from other centres. There is a need to improve surveillance systems in order to allow real time evaluation of interventions and ongoing monitoring of infection trends.
A Note on Evidence Relating to the Incidence of Primary Liver Cancer Among the Bantu&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Alexander G. Gilliam, M. D.
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article A Note on Evidence Relating to the Incidence of Primary Liver Cancer Among the Bantu Get access Alexander G. Gilliam, M. D. Alexander G. Gilliam, M. D. National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 1, August 1954, Pages 195–199, https://doi.org/10.1093/jnci/15.1.195 Published: 01 August 1954 Article history Received: 23 April 1954 Published: 01 August 1954
Five-Year Experience of Early Enteral Feeding in Patients Undergoing Allogeneic Stem Cell Transplantation Following Myeloablative Conditioning.
Authors: David Seguy, Majd Ben Rejeb, Valerie Coiteux, Caroline Dendoncker, Helene Baudelle, Francis Bauters, Jean-Pierre Jouet, Ibrahim Yakoub-Agha
Journal: Blood (2007)
Insulin and the phosphatidylinositol 3-kinase signaling pathway regulate Ribonuclease 7 expression in the human urinary tract
Authors: Tad E. Eichler, Brian Becknell, Robert S. Easterling, Susan E. Ingraham, Daniel M. Cohen, Andrew L. Schwaderer, David S. Hains, Birong Li, Ariel Cohen, Jackie Metheny, Susheela Tridandapani, John David Spencer
Journal: Kidney International (2016)
Screening for health literacy is not the answer
Authors: Vanessa L Kronzer
Journal: BMJ (2016)

It’s quicker and less stigmatizing to make all communication clearer

Engaging patients in treatment decisions is a fundamental component of patient centered care. Poor health literacy can complicate patients’ understanding of the information that is needed to make informed decisions about their care.

Worldwide, at least one in 10 adults lacks level 1 health literacy, or “the most basic information processing skills considered necessary to succeed in today’s world.”1 Nearly half of European adults have “inadequate” or “problematic” health literacy,2 and only 12% of US adults possess a “proficient” standard.3

Low health literacy is dangerous because it is associated with riskier behavior, greater hospitalization rates, and poorer health outcomes, including increased mortality.4 As a result, there has been a recent push …
Clinical and Histologic Features of Lichenoid Mucocutaneous Eruptions Due to Anti–Programmed Cell Death 1 and Anti–Programmed Cell Death Ligand 1 Immunotherapy
Authors: Veronica J. Shi, Nemanja Rodic, Scott Gettinger, Jonathan S. Leventhal, Julia P. Neckman, Michael Girardi, Marcus Bosenberg, Jennifer N. Choi
Journal: JAMA Dermatology (2016)

Antagonist antibodies to programmed cell death 1 (PD-1) and programmed cell death ligand 1 (PD-L1) have shown remarkable activity in multiple tumor types. Recent US Food and Drug Administration approval of such agents for advanced melanoma, non-small cell lung cancer, and renal cell carcinoma has hastened the need to better characterize their unique toxicity profiles.To provide a clinical and pathologic description of the lichenoid mucocutaneous adverse effects seen in patients receiving anti-PD-1/PD-L1 treatment.Patients with advanced cancer who were referred to dermatology at Yale-New Haven Hospital, a tertiary care hospital, after developing cutaneous adverse effects while receiving an anti-PD-1 or PD-L1 antibody therapy either as monotherapy or in combination with another agent were identified. Medical records from 2010 to 2015 and available skin biopsy specimens were retrospectively reviewed.Patient demographic characteristics, concurrent medications, therapeutic regimen, type of disease, previous oncologic therapies, clinical morphology of cutaneous lesions, treatment of rash, peripheral blood eosinophil count, tumor response, and skin histologic characteristics if biopsies were available.Patients were 13 men and 7 women, with a mean (range) age of 64 (46-86) years. The majority of cases (16 [80%]) had a clinical morphology consisting of erythematous papules with scale in a variety of distributions. Biopsies were available from 17 patients; 16 (94%) showed features of lichenoid interface dermatitis. Eighteen patients were treated with topical corticosteroids, and only 1 patient required discontinuation of anti-PD-1/PD-L1 therapy. Only 4 of 20 patients (20%) developed peripheral eosinophilia. Sixteen patients (80%) were concurrently taking medications that have been previously reported to cause lichenoid drug eruptions.Papular and nodular eruptions with scale, as well as mucosal erosions, with lichenoid features on histologic analysis were a distinct finding seen with anti-PD-1/PD-L1 therapies and were generally manageable with topical steroids. Concurrent medications may play a role in the development of this cutaneous adverse effect.
EST Pipeline System: Detailed and Automated EST Data Processing and Mining
Authors: Hao Xu, Ling He, Yuanzhong Zhu, Wei Huang, Lijun Fang, Lin Tao, Yuedong Zhu, Lin Cai, Huayong Xu, Liang Zhang, Hong Yu, Yan Zhou
Journal: Genomics Proteomics & Bioinformatics (2003)

Abstract Expressed sequence tags (ESTs) are widely used in gene survey research these years. The EST Pipeline System, software developed by Hangzhou Genomics Institute (HGI), can automatically analyze different scalar EST sequences by suitable methods. All the analysis reports, including those of vector masking, sequence assembly, gene annotation, Gene Ontology classification, and some other analyses, can be browsed and searched as well as downloaded in the Excel format from the web interface, saving research efforts from routine data processing for biological rules embedded in the data.
Clinical Features and Outcomes of Elderly Patients with Acute Promyelocytic Leukemia (APL) - the Japan Adult Leukemia Study Group APL97 Study.
Authors: Takaaki Ono, Akihiro Takeshita, Yuji Kishimoto, Hitoshi Kiyoi, Masaya Okada, Yasukazu Kawai, Motohiro Tsuzuki, Kentaro Horikawa, Mitsuhiro Matsuda, Katsuji Shinagawa, Fumihiko Monma, Shigeki Ohtake, Chiaki Nakaseko, Masatomo Takahashi, Fumiharu Yagasaki, Yukihiko Kimura, Masako Iwanaga, Norio Asou, Tomoki Naoe, Ryuzo Ohno
Journal: Blood (2010)
Clinical Utility of Combined FDG-PET/MR to Assess Myocardial Disease
Authors: Ronan Abgral, Marc R. Dweck, Maria Giovanna Trivieri, Philip M. Robson, Nicolas Karakatsanis, Venkatesh Mani, Maria Padilla, Marc Miller, Anuradha Lala, Javier Sanz, Jagat Narula, Valentin Fuster, Johanna Contreras, Jason C. Kovacic, Zahi A. Fayad
Journal: JACC. Cardiovascular imaging (2016)
Medical data of 655 000 Americans put up for sale by hacker
Authors: Owen Dyer
Journal: BMJ (2016)

The personal data of 655 000 Americans—stolen by a hacker known as “thedarkoverlord”— has been put up for sale on dark web markets where stolen data are traded.

The hacker stole databases from three organizations: one in Atlanta, Georgia, with 397 000 personal records; another in the midwest with 210 000 records; and the third in Farmington, Missouri, with 48 000 entries. Asking prices for the different databases were $411 000 (£305 000; €368 000), $205 000, and $100 000.

The prices were listed in bitcoin, an untraceable internet currency, and advertised on the Real Deal internet marketplace, …
Recurrent Ventricular Tachycardia — More Drugs or Bring Out the Catheter?
Authors: Michael E. Cain, Anne B. Curtis
Journal: New England Journal of Medicine (2016)

The treatment of patients with ischemic cardiomyopathy and recurrent ventricular tachycardia despite combined treatment with an implantable cardioverter–defibrillator (ICD) and antiarrhythmic drugs can be exceedingly difficult. More than 20 years ago, we found that reentry (a process in which an electrical impulse cycles repeatedly through an area of cardiac tissue) is often the mechanism of scar-related monomorphic ventricular tachycardia.1 Driven by this knowledge, researchers have developed catheter ablation procedures that can be used to target and interrupt reentrant pathways. Ablation procedures are increasingly efficacious when performed at high-volume centers in some groups of patients with ventricular arrhythmias.26 On the . . .
Different Prognosis According to Subtype-Oriented Protocols in Elderly Patients with Acute Lymphoblastic Leukemia (ALL). Comparison of Three Prospective Parallel Trials from the Pethema Group
Authors: Josep-Maria Ribera, Olga Garcia, Pascual Fernandez, Pau Montesinos, Salut Brunet, Maria del Pilar Martinez, Esperanza Lavilla, Teresa Bernal, Jose González, Mar Tormo, Pere Barba, Carmen Monteserín, Josep Sarrá, Marta Fernandez, Mercedes Colorado, Andrés Novo, Antonio Garcia, Maria Calbacho, Eugenia Abella, Maria-Jose Moreno, Jesús-Maria Hernández-Rivas, Maria-Elsa Lopez, Natalia Alonso, Alfons Serrano, Evarist Feliu
Journal: Blood (2013)
Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment
Authors: Hao Yuan Kueh, Mary A Yui, Kenneth K H Ng, Shirley S Pease, Jingli A Zhang, Sagar S Damle, George Freedman, Sharmayne Siu, Irwin D Bernstein, Michael B Elowitz, Ellen V Rothenberg
Journal: Nature Immunology (2016)
Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma
Authors: Hyunseok Kang, Marietta Tan, Justin A. Bishop, Siân Jones, Mark Sausen, Patrick K. Ha, Nishant Agrawal
Journal: Clinical Cancer Research (2016)

Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. To explore the genetic origins of MEC, we performed systematic genomic analyses of these tumors.Whole-exome sequencing and gene copy-number analyses were performed for 18 primary cancers with matched normal tissue. FISH was used to determine the presence or absence of the MECT1-MAML2 translocation in 17 tumors.TP53 was the most commonly mutated gene in MEC (28%), and mutations were found only in intermediate- and high-grade tumors. Tumors with TP53 mutations had more mutations overall than tumors without TP53 mutations (P = 0.006). POU6F2 was the second most frequently mutated gene, found in three low-grade MECs with the same in-frame deletion. Somatic alterations in IRAK1, MAP3K9, ITGAL, ERBB4, OTOGL, KMT2C, and OBSCN were identified in at least two of the 18 tumors sequenced. FISH analysis confirmed the presence of the MECT1-MAML2 translocation in 15 of 17 tumors (88%).Through these integrated genomic analyses, MECT1-MAML2 translocation and somatic TP53 and POU6F2 mutations appear to be the main drivers of MEC. Clin Cancer Res; 23(1); 283-8. ©2016 AACR.