tbuckley/cabot-search huggingface dataset:
FRI0012 IL-17 in Rheumatoid Arthritis Bone Marrow. Not Only Th-17 Cells
Authors: E. Kuca-Warnawin, W. Kurowska, M. Prochorec-Sobieszek, A. Radzikowska, T. Burakowski, M. Plebanczyk, I. Słowinska, R. Gasik, W. Maslinski
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Inflammatory process in bone marrow (BM) observed on MRI scans of rheumatoid arthritis (RA) patients (called bone marrow oedema) together with autoantibodies production was shown to proceed joint destruction in RA. Our previous studies supported the concept that BM actively participate in the pathogenesis of RA by TLR triggered B cell activity (1) and increased number of activated T cells (2). <h3>Objectives</h3> In the present study we investigated IL-17 producers in BM. <h3>Methods</h3> BM and peripheral blood (PB) samples were obtained from RA and osteoarthritis (OA) patients during total hip replacement surgery. Levels of IL-17AF, IL-17FF, IL-17AA, GMCSF and IL-21 in bone marrow plasma were determined by specific ELISA. Th1/Th2/Th17 proportions were evaluated by flow cytometry. To confirm production of IL-17 in BM immunohistochemistry examination was done. Comparison between the groups of patients were analysed by two-tailed Mann-Whitney U test. <h3>Results</h3> We observed increased level of IL-17AF (147±104 pg/ml vs 115±74pg/ml, p&lt;0,05) in bone marrow plasma from RA in comparison to OA. In contrast similar levels of IL-17FF were detected in RA BM (94± 115pg/ml) and OA BM plasma (44±66pg/ml). IL-17AA was not detected. Concentrations of both IL-17AF and IL-17FF were higher in BM than in PB. Surprisingly there were no differences between RA BM and OA BM levels of Th-17 related cytokines such IL-21 and GMCSF. We did not observe any statistically significant differences in percentage of IL-17, IFNγ or IL-4 producing lymphocytes in RA BM and OA BM. Immunohistological staining confirmed higher expression of IL-17 in RA BM in comparison to OA BM. We also observed strong IL-17 staining in granulocytes. <h3>Conclusions</h3> IL-17AF is overproduced in RA bone marrow. There are two main sources of these cytokine in RA BM: T cells and granulocytes <h3>References</h3> W Rudnicka et al.: Eur J Immunol 2009; 1211–20 E Kuca-warnawin et al.: Ann Rheum Dis 2011;227–33 <h3>Acknowledgement</h3> This work was sponsored by by grant No UMO-2011/03/B/NZ6/05035 from National Science Centre <h3>Disclosure of Interest</h3> None declared
Consent for anaesthesia—sleepwalking into trouble
Authors: Michael H Basler, Alan J R Macfarlane, Sonya McKinlay
Journal: BMJ (2016)

The Royal College of Surgeons has highlighted the operational issues raised after the Montgomery judgment on consent,1 which have wider implications.2

Anaesthesia in the UK has resisted formal consent and relies on the preoperative visit as the foundation for discussion of techniques. Obstetric and regional …
The Impact of Rituximab and Radiotherapy On Treatment Outcome of Patients with DLBCL and Skeletal Involvement
Authors: Gerhard Held, Samira Zeynalova, Niels Murawski, Marita Ziepert, Barbara Kempf, Andreas Viardot, Martin Dreyling, Michael Hallek, Mathias Witzens-Harig, Christian Ruebe, Christian Berdel, Carsten Zwick, Norbert Schmitz, Michael Pfreundschuh
Journal: Blood (2012)
PARE0012 Revma Challenge 2015 – Give A Helping Glove and Support A Patient with Rheumatoid Arthritis
Authors: H. Smucrova
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Czech League Against Rheumatism plays an important role in promoting rheumatic patients in the Czech Republic. Its activity is aimed at raising awareness about rheumatic diseases, the struggle for full and equal life for people with rheumatic diseases and the establishment of regional clubs of Czech League Against Rheumatism. <h3>Objectives</h3> Create a campaign aimed to raise awareness about rheumatoid arthritis - a serious disease that destroys lives insidious way over 100,000 inhabitants of the Czech Republic. When most people understand the nature of rheumatoid arthritis, they can better help the patients manage their daily struggle with the disease. <h3>Methods</h3> Creating a campaign… "Give a helping glove and support a patient with rheumatoid arthritis" with the participation of experts from rheumatology and also the participation of personalities from the cultural and scientific life. Rheumatoid arthritis is most often manifested impairment of the joints of the hands. The symbol of the campaign thus became a special glove, developed by scientists from the Institute of Technology in the US, Georgia. These gloves can restrict the movement of the fingers and hand grip strength using metal plates - and faithfully simulate the symptoms of the disease. It can show a healthy people feeling in the shoes of people with rheumatoid arthritis. Creating a video with personalities who use gloves to perform daily activities and leisure activities. <h3>Results</h3> The main outcome of the campaign was the debate with an expert on the generation of positioning whitepaper document for timely treatment for patients with rheumatic disease. In response to the campaign has increased the number of members in Czech League Against Rheumatism, an increased number of visitors and fans of the Facebook page Czech League Against Rheumatism. It managed to raise awareness of rheumatic diseases among the general public. <h3>Conclusions</h3> This campaign seems to be very useful in influencing the professional and lay public. It is one of the ways how they can be involved in the functioning of the organization. <h3>References</h3> Czech PARE organization - Czech League Against Rheumatism <h3>Disclosure of Interest</h3> None declared
A Novel Mutation (Q694X) in the ITGB3 Gene Causing Glanzmann’s Thrombasthenia from the Sultanate of Oman
Authors: Talal Albalushi, Shoaib AlZadjali, Hamood AlHaddabi, J. David Dennison, Salam Alkindi, Shanmugaonkar Muralitharan, Tadao Arinami, Anil Pathare
Journal: Blood (2008)
Testing the Immunity of the Firearm Industry to Tort Litigation
Authors: David M. Studdert, John J. Donohue, Michelle M. Mello
Journal: JAMA Internal Medicine (2016)

In the absence of congressional action to reinstate the federal ban on assault weapons, tort litigation offers an alternative strategy for regulating what have become the weapons of choice in mass shootings. However, opportunities to bring successful claims are limited. To prevail, plaintiffs must show that their suit fits within exceptions to the broad immunity from tort actions that Congress gave the firearm industry in the 2005 Protection of Lawful Commerce in Arms Act. In one particularly high-profile lawsuit, families of victims of the school shooting in Newtown, Connecticut, in 2012 sued the makers and sellers of the military-style rifle used in the attack, alleging negligence and deceptive marketing. The trial court dismissed the case on October 14, 2016, but the plaintiffs plan to appeal. We review the history of tort litigation against the firearm industry, outline the Newtown families’ claims, and describe the decision.
Conditional Activation of Bcr-Abl Kinase Delineates Time-Dependent Transforming Events in Hematopoietic Cells.
Authors: Ratanakanit Harnprasopwat, Kiyoko Izawa, Seiichiro Kobayashi, Ai Kotani, Naoyuki Takahashi, Arinobu Tojo
Journal: Blood (2009)
Efficacy of switching from adefovir to tenofovir in chronic hepatitis B patients who exhibit suboptimal responses to adefovir-based combination rescue therapy due to resistance to nucleoside analogues (SATIS study)
Authors: Hye Won Lee, Jun Yong Park, Beom Kyung Kim, Moon Young Kim, Jung Il Lee, Young Suk Kim, Ki Tae Yoon, Kwang-Hyub Han, Sang Hoon Ahn
Journal: Clinical and Molecular Hepatology (2016)

See the commentary-article "Switch to tenofovir-based therapy or to continue adefovir-based therapy in CHB patients with suboptimal response to adefovir-based combination?" on page 439.
Hémorragies digestives hautes communautaires: résultats préliminaires de l'étude de l'ANGH sur plus de 1000 patients
Authors: H Hagège, JP Latrive, B Nalet, I Rosa, B Bour, R Faroux, P Gower, JP Arpurt, J Denis, J Henrion, A Pariente, L Marek
Journal: Endoscopy (2006)

Les hémorragies digestives hautes (HDH) représentent l'une des principales urgences en hépato-gastroentérologie. L'objectif principal de cette étude est de décrire les caractéristiques épidémiologiques actuelles des HDH communautaires et également les pratiques professionnelles, la morbidité et la mortalité hospitalière.
CDC Grand Rounds: A Public Health Approach to Detect and Control Hypertension
Authors: Rikita Merai, Claudia Siegel, Michael Rakotz, Peter Basch, Janet Wright, Betty Wong, Phoebe Thorpe
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Hypertension is generally defined as systolic blood pressure ≥140 mmHg, or diastolic blood pressure ≥90 mmHg. A person who currently uses blood pressure-lowering medication is also defined as having hypertension. Hypertension is a leading risk factor for cardiovascular disease and stroke (1,2). Hypertension affects nearly one third of U.S. residents aged ≥18 years (approximately 75 million persons), and in approximately one half of adults with hypertension (nearly 35 million persons), it is uncontrolled (2). Among these 35 million U.S. residents with uncontrolled hypertension, 33% (11.5 million persons) are not aware of their hypertension, 20% (7 million persons) are aware of their hypertension, but are not being treated for it, and approximately 47% (16.1 million persons) are aware of their hypertension and being treated for it, but treatment (by medication and/or lifestyle modification) is not adequately controlling their blood pressure (Figure) (2).
Apoptotic Blebs From Leukemic Cells as a Source of Tumor Associated Antigen for Monocyte-Derived Dendritic Cell Loading
Authors: Jurjen M Ruben, Hetty J Bontkes, Theresia M. Westers, Willemijn van Den Ancker, Gert J. Ossenkoppele, Tanja D de Gruijl, Arjan A. Van de Loosdrecht
Journal: Blood (2010)
Discrepancy of CD20 Protein Expression In IHC and FCM Analyses In Primary B-Cell Lymphoma: Relationship Between FCM-Negative Phenotype and Rituximab Binding with Lymphoma Cells
Authors: Takashi Tokunaga, Akihiro Tomita, Kazuyuki Shimada, Junji Hiraga, Takumi Sugimoto, Naoe Goto, Tsuyoshi Takami, Tomohiro Kinoshita, Tomoki Naoe
Journal: Blood (2010)
SAT0273 Corticosteroids as Rescue Therapy for Resistant Kawasaki Disease
Authors: L. Das, K.L. Teh, M. Tanya, S. Yoo, J.H.T. Tan, J.T.L. Choo, T.H. Tan, T. Arkachaisri
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Kawasaki Disease (KD) is one of the most common systemic vasculitidies in children today. IVIG is the mainstay of treatment, however, about 1/5 of patients do not respond (Teraguchi) resulting in an increased risk of Coronary Artery Abnormalities (CAA). Based on the current literature and from experience it is our preference to use Intravenous Methylprednisolone (IVMP) in the treatment of IVIG resistant Kawasaki Disease (rKD) patients. <h3>Objectives</h3> To examine the differences in CAA seen in patients who were treated with IVMP versus retreatment with IVIG <h3>Methods</h3> Demographic, clinical manifestations and echocardiogram data were collected and analyzed. Descriptive statistics were used to describe the data. Chi square/Fisher Exact Test were used to test association, student t test or Mann Whitney U were used to compare the data where appropriate. Kaplan Maier analysis was used to assess the time to CAA resolution. Significance was set at 0.05. <h3>Results</h3> Of the 78 rKD patients included (type of KD: complete 55, incomplete 23), 33 received 2nd IVIG and 45 received IVMP. 13 rKD patients who failed the 2nd IVIG treatment were excluded from the analysis (2nd IVIG failure 27.7%). Median age at onset was 1.5 years (IQR 0.76, 2.58) and 45 patients were male. There was no significant difference in regards to gender (p=0.63), age at onset (p=0.14), type of KD (p=0.89) or KD clinical manifestations between treatment groups (p=0.25–0.56). 88.9% of IVMP and 57.6% of 2nd IVIG patients had CAA prior to therapy (p=003). The median duration to completing CAA resolution was 1.19 years; 2nd IVIG group (IQR 0.62, 2.43) and IVMP (IQR 0.84, 3.27). Time to achieve CAA resolution was not different between treatment groups (p=0.11, Figure 1). <h3>Conclusions</h3> Between 2nd IVIG and IVMP as rKD rescue therapy, there was no difference in duration of achieving CAA resolution. Our group has described higher number of rKD with CAA prior to IVMP treatment. A larger, prospective randomized controlled trial is needed to confirm our preliminary observations for which this is underway in our region. <h3>References</h3> Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment, and long term management of Kawasaki disease. Circulation 2004;110:2747–71 Teraguchi M, Ogino H, Yoshimura K, et al. Steroid pulse therapy for children with intravenous immunoglobulin therapy-resistant Kawasaki disease: a prospective study. Pediatr Cardiol. 2013 Apr;34(4):959–63. <h3>Disclosure of Interest</h3> None declared
Iron Overload and Haematopoiesis in MDS: Does Blood Transfusion Promote Progression to AML?
Authors: Lap Shu Alan Chan, Rena Buckstein, Marciano D. Reis, Alden Chesney, Adam Lam, Matthew C Cheung, Eugenia Piliotis, Lilly Chunhong Gu, Richard A. Wells
Journal: Blood (2008)
the γ Isoform of the Glucocorticoid Receptor Is Ontogenetically Activated and Predicts Poor Ex-Vivo Expansion of Erythroid Cells From Adult Blood.
Authors: Giovanni Migliaccio, Massimo Sanchez, Francesca Masiello, Valentina Tirelli, Lilian Varricchio, Barbara Ghinassi, Carolyn Whitsett, Anna Rita Migliaccio
Journal: Blood (2009)
THU0037 Personality Traits in Patients with Rheumatoid Arthritis: An Unrecognized Predictor of Mortality
Authors: A.D. Crowson, R.C. Colligan, E.L. Matteson, J.M. Davis, C.S. Crowson
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Psychosocial factors, such as pessimistic explanatory style, are shown to affect the course of treatments in many illnesses (Cardiovascular diseases, lung cancer, Parkinson9s disease). Little is known about how pessimistic explanatory style affects rheumatoid arthritis (RA). <h3>Objectives</h3> The aim of this study was to determine if pessimistic explanatory style altered the risk for and mortality rates of RA patients. <h3>Methods</h3> The study used a subset of patients who completed the Minnesota Multiphasic Personality Inventory (MMPI) from among a population-based cohort with incident RA in 1955–2007 and an age- and sex-matched non-RA comparison cohort. Only patients who were ≥18 and fulfilled the American College of Rheumatology (ACR) 1987 criteria for RA were included. Pessimistic explanatory style was measured using the Optimism-Pessimism scale (PSM≥60). Logistic regression and Cox models were used to examine the associations between pessimistic explanatory style and development of RA or mortality rates. <h3>Results</h3> There were 148 RA and 135 non-RA subjects who completed the MMPI. Pessimistic explanatory style was associated with development of rheumatoid factor positive (RF+) RA (odds ratio [OR]:1.74; 95% confidence interval [CI]: 0.99–3.04; p=0.053 adjusted for age, sex, smoking and obesity). Among patients with RA, mortality risk adjusted for age, sex, year, smoking, and Charlson Comorbidity Index was increased with a pessimistic explanatory style (hazard ratio [HR]:2.88; 95%CI: 1.02–8.14), similar to mortality risk in RF+ RA patients (HR:2.28; 95%CI:1.10–4.73). A significant interaction between RF+ and pessimistic explanatory style indicated that having both did not confer an additive effect (p=0.037). The 10 year survival percentages were highest for those with RF-RA who were not pessimistic (93%) and were similar for patients with RF+RA who were not pessimistic (73%), those with RF-RA who were pessimistic (77%), and those who were both RF+RA and pessimistic (84%). This association did not change after adjusting for the MMPI depression scale or a history of depression prior to diagnosis of RA. <h3>Conclusions</h3> Having a pessimistic explanatory style was associated with an increased risk of developing RA and increased mortality rate in patients with RA. In these patients, the effects of RF+ and pessimistic style were not additive. The patient9s psychological state strongly affects treatment decisions and outcomes and can inform about the usefulness of mindful interventions (e.g. cognitive behavioral therapy). Understanding the explanatory style is an important step in the holistic management of disease and a vital component of integrated care. <h3>Disclosure of Interest</h3> None declared
Clinical Characteristics and Outcome of Isolated Extramedullary Relapse in Acute Leukemia Following Allogeneic Stem Cell Transplantation: A Single Institutional Analysis
Authors: Jimin Shi, Xiaojian Meng, Yi Luo, Yamin Tan, Xiaoli Zhu, Gaofeng Zheng, Jingsong He, Weiyan Zheng, Wanzhuo Xie, Li Li, Xiujin Ye, Jie Zhang, Zhen Cai, Maofang Lin, He Huang
Journal: Blood (2012)
MGD011, Humanized CD19 x CD3 DART® Protein with Enhanced Pharmacokinetic Properties, Demonstrates Potent T-Cell Mediated Anti-Tumor Activity in Preclinical Models and Durable B-Cell Depletion in Cynomolgus Monkeys Following Once-a-Week Dosing
Authors: Liqin Liu, Annie Lam, Ralph Alderson, Yinhua Yang, Hua Li, Vatana Long, Sergey Gorlatov, Steve Burke, Valentina Ciccarone, Jeffrey Nordstrom, Syd Johnson, Paul Moore, Ezio Bonvini
Journal: Blood (2014)
Preemptive Donor Lymphocyte Infusion Induces Polyspecific T-Cell Responses in a Patient with AML with NPM1 Mutation
Authors: Susanne Hofmann, Marlies Götz, Cornelia Herbst, Vanessa Schneider, Lu Zhang, Donald Bunjes, Hartmut Döhner, Markus Wiesneth, Jochen Greiner
Journal: Blood (2011)
Phase I Study of the Novel Surivin and cdc2/CDK1 Inhibitor Terameprocol in Patients with Advanced Leukemias.
Authors: Raoul Tibes, Kevin T. McDonagh, Lazaros Lekakis, Neal Frazer, Scott Mohrland, Bassett Dawn, Reynaldo Garcia, Katy Schroeder, Vijayalakshmi Shanmugam, John Carpten, Daniel Von Hoff, Thomas C. Shea
Journal: Blood (2009)
A Phase I Study of Tipifarnib Combined with Conventional Induction and Consolidation Therapy for Previously Untreated Patients with Acute Myeloid Leukemia Age 60 and Over.
Authors: Joseph M. Brandwein, Brian F. Leber, Kang Howson-Jan, Aaron D. Schimmer, Andre C. Schuh, Vikas Gupta, Karen W.L. Yee, Mark D. Minden
Journal: Blood (2007)
Clear Cell Type A and B Molecular Subtypes in Metastatic Clear Cell Renal Cell Carcinoma: Tumor Heterogeneity and Aggressiveness
Authors: Daniel J. Serie, Richard W. Joseph, John C. Cheville, Thai H. Ho, Mansi Parasramka, Tracy Hilton, R. Houston Thompson, Bradley C. Leibovich, Alexander S. Parker, Jeanette E. Eckel-Passow
Journal: European Urology (2016)
p16INK4a Is a Key Downstream Mediator of the Deleterious Effects of FoxO Deficiency on Maintenance of the Hematopoietic Stem Cell Compartment.
Authors: Zuzana Tothova, Stephen M Sykes, Dena S Leeman, James W Horner, Norman Sharpless, Ronald A DePinho, D. Gary Gilliland
Journal: Blood (2008)
BMET-08DIAGNOSTIC ACCURACY OF PET, SPECT, AND ASL IN DIFFERENTIATING TUMOR RECURRENCE FROM NECROSIS IN CEREBRAL METASTASIS POST-STEREOTACTIC RADIOSURGERY
Authors: Grace Lai, Anand Mahadevan, David Hackney, Peter Warnke, Ekkehard Kasper, Eric Wong, Bob Carter, Clark Chen
Journal: Neuro-Oncology (2015)

BACKGROUND AND PURPOSE: Radiographic assessment of cerebral metastasis after stereotactic radiosurgery (SRS) remains a major challenge in neuro-oncology. It is often difficult to distinguish tumor progression (TP) from radiation necrosis (RN) in this setting using conventional MRI. The objective of this study is to compare the diagnostic sensitivity and specificity of different functional imaging modalities for detecting tumor recurrence after SRS. MATERIALS AND METHODS: We retrospectively reviewed patients treated between 2007 and 2010 and identified 14 patients with cerebral metastasis who suffered clinical or radiographic progression following SRS and were imaged with arterial spin labeling (ASL), FDG-PET, and Thallium-SPECT prior to stereotactic biopsy. Diagnostic accuracy, specificity, sensitivity, positive predictive value, and negative predictive value were calculated for each imaging modality using pathologic diagnosis as gold standard. RESULTS: Six patients (42%) suffered tumor progression while eight (58%) developed radiation necrosis. FDG-PET and ASL were equally sensitive in detecting tumor progression (83%). However, the specificity of ASL was superior to the other modalities (100%, 75%, and 50% respectively). Combination of modalities did not augment the sensitivity, specificity, PPV, or NPV of ASL. CONCLUSION: In our series, ASL positivity closely associates with pathological diagnosis of tumor progression after SRS. The sensitivity and specifity of ASL in detecting tumor progression is superior to those of PET and SPECT.
Inotuzumab Ozogamicin in Combination with Low-Intensity Chemotherapy (mini-hyper-CVD) As Salvage Therapy for Adult Patients with Refractory/Relapse (R/R) Acute Lymphoblastic Leukemia (ALL)
Authors: Elias Jabbour, Susan O'Brien, Deborah A. Thomas, Koji Sasaki, Guillermo Garcia-Manero, Tapan Kadia, Nitin Jain, Sergernne York, Rebecca Garris, Jorge E. Cortes, Hagop M. Kantarjian
Journal: Blood (2014)
Stable Suppression of a Novel Oncogene, AHI-1, in Human Cutaneous T-Cell Leukemia Cells Normalizes Its Transforming Activity In Vitro and In Vivo and Aberrant Expression of AHI-1 Is Also Present in Leukemic Sezary Cells from Patients with Sezary Syndrome.
Authors: Ashley Ringrose, Youwen Zhou, Emily Pang, Ann E.-J. Lin, Xiao-Jiang Li, Irene Li, Andrew Weng, Xiaoyan Jiang
Journal: Blood (2005)