tbuckley/cabot-search huggingface dataset:
Prospective evaluation of the frequency of Late Reversibility in SPECT T1-201 Stress Redistribution Studies.
Authors: Ling de Yang, Daniel Berman, Hosen Kiat, Kenneth Resser, John Friedman, Adrian Antonescu, Alan Rozanski, Jamshid Maddahi
Journal: Clinical Nuclear Medicine (1988)

de Yang, Ling; Berman, Daniel; Kiat, Hosen; Resser, Kenneth; Friedman, John; Antonescu, Adrian; Rozanski, Alan; Maddahi, Jamshid Author Information
MS-07 * MENINGIOMA OF THE PEDIATRIC SKULL BASE: A REVIEW
Authors: W. Gump
Journal: Neuro-Oncology (2014)

Pediatric skull base meningiomas are rare and complex clinical entities. Meningioma is a relatively uncommon brain tumor in children, and only about 27% involve the skull base. Some evidence suggests that these tumors are more likely to be atypical or malignant in children than adults. The absence of female preponderance in pediatric meningiomas is reflected in the skull base subpopulation. Skull base meningiomas in children are most likely to be found in the anterior or middle fossa base, or involving the orbit and optic nerve sheath. Petroclival, suprasellar/parasellar, cerebellopontine angle, cavernous sinus, and foramen magnum tumors are very rare. Meningiomas constitute a small proportion of reported cases of pediatric skull base pathology, and are entirely absent from many case series. Initial gross total resection is consistently associated with superior outcomes. Surgical approaches to the pediatric skull base must take additional factors into consideration including relatively smaller anatomy, immature dentition, incompletely aerated sinuses and air cells, and altered configurations of structures such as the pterional bony complex. Multidisciplinary expertise is essential to optimizing treatment outcomes.
Clinical acute pancreatitis following anterograde single balloon enteroscopy
Authors: M. Sharma, P. Sharma, H. Garg, L. Sehgal, V. Bhatia
Journal: Endoscopy (2011)

A 37-year-old woman with suspicion of Crohn's disease underwent capsule endoscopy; however, the capsule was still in the small bowel even after 14 days. Anterograde single balloon enteroscopy (SBE) was planned to retrieve the capsule and to simultaneously carry out a biopsy. On SBE, multiple ulcers and one major stricture were found in the distal bowel with the capsule lying over the stricture ([Fig. 1 a, b]). The capsule was successfully retrieved and multiple biopsy samples were taken, with the procedure lasting 3 hours. Following the procedure, the patient developed severe upper abdominal pain. Investigations revealed serum amylase of 1217 U/L at 24 h post procedure. Although previous computed tomography (CT) scans had shown a normal pancreas ([Fig. 2]), a further CT scan of the abdomen showed a bulky pancreas with peripancreatic fluid collections ([Fig. 3]). The patient was managed conservatively and discharged on day 7. The small bowel biopsy showed features consistent with Crohn's disease.
AB0369 Clinical Features of Elderly-Onset Rheumatoid Arthritis Started with the Acute Onset
Authors: Y. Mukofujiwara, I. Sekiya, N. Takada, Y. Hayashi, Y. Shibata, Y. Katuda
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Elderly-onset rheumatoid arthritis (EORA) is defined as rheumatoid arthritis (RA) with onset at age 60 or over. In addition to population -growth in the elderly, EORA is also increasing. EORA shows some peculiarities. One of them is tendency for the onset to be acute and infectious-like. <h3>Objectives</h3> To identify the clinical features of EORA started with the acute onset, accompanied by constitutional symptoms including high fever and weight loss. <h3>Methods</h3> 62 early EORA patients (&gt;65 years) who first visited our department from April in 2008 were reviewed. Of the 62 EORA patients, 11 patients with abrupt onset were enrolled: 8 women, 3 men age from 66-81 (mean 74±3.4). The patients were diagnosed as RA if they met the 2010 ACR/EULAR criteria or 1987 ACR revised criteria. Clinical, laboratory, and radiographic characteristics at onset and after follow up of 3 years are presented. <h3>Results</h3> An initial clinical presentation resembles polymyalgia rheumatica in 3 patients and purulent arthritis in 2 patients. The average 28-joint disease activity score (DAS28) at the onset was 6.14±1.29. All patients had high CRP level (11.36±6.74 mg/dl) and only 4 patients (36.3%) were positive for anti-cyclic citrullinated peptides antibody (anti CCP). Methotrexate (MTX) were used in all patients and 5 needed biologic agent. Although the weekly MTX dose was low (6±1.29mg), adverse event occurred in 3 patients. The DAS 28 decreased at 3years (3.12±0.9). Because of rapidly progressive joint destruction of the hip and knee joints in 2cases within one year, they underwent toal joint arthroplasty. These 2 patients were anti CCP negative and it took several months before diagnosis of RA. <h3>Conclusions</h3> EORA started with the acute onset had high disease activity. While constitutional symptoms led to delay in correct diagnosis, joint destruction rapidly progressed. EORA with the acute onset should be treated with appropriate DMARDs and biologic agents. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6074
P737 DEVELOPMENT OF A MODEL TO PREDICT PROGRESSION TO CIRRHOSIS IN CHRONIC HEPATITIS C PATIENTS WHO FAILED ANTIVIRAL THERAPY
Authors: S. Lens, F. Torres, I. García-Juárez, M.C. Londoño, S. Martínez, R. Miquel, A. García-Criado, R. Gilabert, C. Bru, J.M. Sánchez-Tapias, X. Forns
Journal: Journal of Hepatology (2014)
COMMENTS
Authors: Robert A. Cleghorn
Journal: American Journal of Psychiatry (1961)

In closing this attempt to review the Third World Congress of Psychiatry, it should be remarked that it has not been possible to achieve the impossible. No one could encompass this meeting in its entirety. Too much took place, too many papers ran concurrently for anyone to experience it all. Like the fable of the elephant and the blind men, it was felt in different ways. Only by implication could one infer that what one touched was part of a considerable colossus which, like the elephant, was packed with wisdom and like that beast would go trumpeting on over incredible obstacles but responsive to the will of its trainer.
Abstract 1634: Reduced NIMA-related kinase 2 (Nek2) expression levels enhance paclitaxel sensitivity in breast cancer cells
Authors: Jaehyung Lee
Journal: Cancer Research (2010)

Abstract While many clinical trials have shown that the taxane, paclitaxel (Taxol™), is a very powerful anticancer drug, paclitaxel is still controversial in its applicability for cancer treatment because of the resistance of tumor cells to its effects. Therefore, the purpose of this study is to determine whether the sensitivity of paclitaxel is improved with the addition of antisense oligonucleotides (ASO) against NIMA related kinase 2 (Nek2) in the breast cancer cells. Nek2, a serine/threonine kinase is a gene emerging as important to cancer development because of its regulatory role in mammalian cell mitosis. Moreover, abnormally increased Nek2 expression and activity levels are the main trait of various cancer cells. For these reasons, regulation of the Nek2 expression levels may prove important as a target for cancer treatment. Studies suggest that depletion of Nek2 results in mitotic arrest and ultimately leads to apoptosis in cancer cells. Because many cancer cells have demonstrated resistance to anticancer drugs, more effective therapeutic treatments for cancer patients are necessary. To overcome this treatment resistance, gene silencing through ASO has emerged as an attractive alternative. ASO are able to inhibit cancer progression because they bind to and depress, the expression of genes targeted for their involvement in tumor development. There are currently clinical trials using ASO for cancer patients suffering from a variety of cancers such as breast, colon, and prostate. In this study, we investigated drug sensitivity by using plus ASOs targeted against Nek2 to treat breast cancer cells. MDA-MB-468 breast cancer cells transfected with Nek2 ASO were treated with paclitaxel to evaluate cell proliferation, cell cycle distribution, and apoptosis. We detected that MDA-MB-468 cells treated together with Nek2 ASO and paclitaxel showed more synergistic results compared with either agent alone. Nek2 ASO worked with paclitaxel in the arrest of the cell cycle at the G2-M phase and lead to apoptosis as well. This study suggests that Nek2 ASO and paclitaxel combination treatment of cancer cells may strongly improve the sensitivity of cancer cells. Thus, these results possibly provide a new strategy for the treatment of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1634.
DECREASING HOSPITAL UTILIZATION OF A HIGH RISK HEART FAILURE POPULATION IN A LARGE URBAN ACCOUNTABLE CARE ORGANIZATION: THE USE OF A CLINICAL PHARMACIST, SERIAL BIOMARKERS, AND POINT OF CARE ULTRASOUND
Authors: Ilan Kedan, Kade Birkeland, Raymond Zimmer, Ronald Halbert, Nareg Minissian, Raj Khandwalla
Journal: Journal of the American College of Cardiology (2016)
Abstract 3649: Contribution of fatty acid accumulation to myeloid-derived suppressor cell function in cancer
Authors: Wei Cao, Dmitry Gabrilovich
Journal: Cancer Research (2011)

Abstract MDSCs are a heterogeneous population of cells that consists of myeloid progenitor cells and immature myeloid cells (IMCs). In healthy individuals, IMCs that are generated in the bone marrow quickly differentiate into mature granulocytes, macrophages or dendritic cells (DCs). By contrast, under pathological conditions, such as cancer, a partial block in the differentiation of IMCs and activation of these cells results in the expansion of the population with potent immune suppressive activity – myeloid-derived suppressor cells. We investigated the mechanism of MDSC effect on immune system and focused our attention on possible role of fatty acids (FA) in this process. Recently, we found FA accumulation in dendritic cells (DCs) from tumor bearing mice or cancer patients. It was caused by increased uptake of extracellular lipids due to up-regulation of scavenger receptor A. FA accumulation in DCs resulted in the dysfunction of DCs. Pharmacological normalization of lipid abundance in DCs with an inhibitor of acetyl-CoA carboxylase restored the functional activity of DCs and substantially enhanced the effects of cancer vaccines. In parallel, we also observed dramatic lipid accumulation in MDSC from tumor bearing mice. Interestingly, MDSCs don't have up-regulation of scavenger receptor A, but instead have increased expression of fatty acid transporter FATP4. Over-expression of FATP4 in MDSCs induced lipid accumulation. This suggested that FATP4 may be involved in the accumulation of lipid in these cells. MDSCs with lipid overload exerted stronger inhibitory effect on immune cells than MDSC with normal lipid level. MDSCs treated with unsaturated FA linoleic acid displayed stronger inhibitory effect than MDSCs treated with saturated FA palmitic acid. Since MDSCs has strong oxidizing environment, the data suggested that oxidized FA may be involved in the inhibitory effect of MDSCs. Elucidation of this mechanism in detail will be helpful for the development of potential therapeutic targets regulating immune function in tumor-bearing hosts. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3649. doi:10.1158/1538-7445.AM2011-3649
Abstract A25: CK 5/6 and EMT-markers as poor prognostic factors in breast cancer patients
Authors: Tomasz Ahrends, Aleksandra Markiewicz, Paweł Nowialis, Barbara Seroczy ska, Jarosław Skokowski, Jolanta Szade, Marzena Wełnikca-Ja kiewicz, Anna aczek
Journal: Cancer Research (2011)

Abstract Introduction: Cytokeratins 5/6 are expressed in basal layer of breast epithelium and are considered as markers of poor prognosis in breast cancer patients. It was also shown that tumors expressing basal markers often present phenotypical changes connected with epithelial-to-mesenchymal transition (EMT), like vimentin expression and E-cadherin loss. The aim of this study was to evaluate the expression of master regulators of EMT - TWIST, SNAIL and SLUG in breast cancer samples and correlate it with expression of CK 5/6 and markers of EMT - E-cadherin and vimentin. Materials and Methods: Fresh-frozen and FFPE tumor samples from 136 consecutive, stage l-III breast cancer patients were examined. Expression of TWIST, SNAIL and SLUG in frozen tissues was measured by RT-qPCR method using ΔΔCt approach. Expression of CK 5/6, E-cadherin and vimentin was analyzed in FFPE material with a use of immunohistochemical staining of tissue microarrays (TMA-IHC). Based on the median gene expression level or intensity of the IHC staining samples were classified as positive or negative for a particular marker. Results were correlated with clinicopathological data of the patients and their outcome. Results: CK 5/6 staining was positive in 19 (11.3%) of the samples and correlated positively with presence of EMT phenotype (0.00027, χ2 test), with 58% and 19.5% of EMT-positive samples in CK5/6 positive and negative subgroup, respectively. Moreover, elevated expression of SNAIL mRNA was detected more often in CK 5/6 positive than in negative samples (89% vs. 51 %, p=0.032, Fisher's exact test). Elevated expression of TWIST (p=0.05, Fisher's exact test) and SNAIL (p=0.003, Fisher's exact test) genes was found in tumors with EMT phenotype. No correlation was found between TWIST, SNAIL, SLUG protein levels as well as SLUG gene expression and EMT phenotype. Expression of CK 5/6 was associated with decreased DFS (p = 0.00044, log-rank test) and OS (p = 0.00001, log-rank test), while occurrence of EMT phenotype with worse OS (p=0.01, log-rank test) Conclusions: CK 5/6 was found to be a marker of poor prognosis in terms of DFS and OS in the whole studied group of patients. EMT phenotype and SNAIL gene overexpression were more frequent in CK 5/6-positive tumors, which suggests a link between basal phenotype of the tumors and their predisposition to undergo EMT process. As EMT is thought to confer aggressive behavior of the tumor, this correlation might explain the observed negative impact of CK5/6 positive tumors on patients' survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A25.
Optimizing Breast Cancer Follow-Up: Diagnostic Value and Costs of Additional Routine Breast Ultrasound.
Authors: S. Wojcinski, E. Hirschauer, F. Degenhardt, W. Schmidt
Journal: Cancer Research (2009)

Abstract Background: Standard means in breast cancer follow-up include clinical examination and mammography for the detection of local recurrences. Additional test will only be conducted if there are unclear or suspicious findings. Ultrasound has not yet been established as a routine method for breast cancer follow-up care. Our study evaluates the diagnostic efficacy of breast ultrasound in detecting occult malignancies. Moreover, we analyzed the effect of false positive findings resulting in additional examinations and biopsies, and we conducted a benefit-cost-analysis and a questioning of the affected patients.Materials and Methods: A total of 879 eligible patients who were seen at the University Hospital of Saarland for the purpose of breast cancer follow-up were recruited between October 2004 and January 2006. All patients received clinical examination and mammography and were then divided into 2 groups. Group 1 (n=703) were clinically and mammographically asymptomatic patients. Group 2 (n=176) had abnormalities either in palpation or mammography. All patients received additional ultrasound in order to detect occult malignancies. Both groups were analyzed with respect to the diagnostic value of additional ultrasound, the rate of additional examinations and biopsies, the extra costs and the individual stress as experienced by the patient.Results: In group 1 (asymptomatic patients) 10 occult malignancies were detected due to the additional ultrasound examination, i.e. one diagnosed malignancy in 70 examined patients (detection rate 1.4%). By reason of false positive ultrasound results, 65 additional control-ultrasounds, 14 additional MRI examinations and finally 22 biopsies of benign lesions were unnecessarily conducted. Weighing in the total costs for ultrasound, MRI and biopsy, an amount of 4150€ (5290$) was spent to find one additional cancer.In group 2, apart from the symptomatic lesions, 3 occult malignancies were exclusively identified due to the ultrasound examination (detection rate 1.7%). On the other hand, false positive ultrasound results caused 7 additional control-ultrasounds, 14 additional MRIs and 11 biopsies of benign lesions. Hence, an amount of 4410€ (5620$) was spent to identify one additional malignancy by the means of additional ultrasound in this group.Overall, 50 patients (5.7%) received biopsy due to false positive results either in ultrasound or mammography, but these patients claimed on questioning not to feel “troubled and anxious”, but “saver and more carefully looked after”.Discussion: Regarding our results, we strongly recommend the routine use of ultrasound in breast cancer follow-up for both, asymptomatic and symptomatic, women, as occult malignancies can be identified cost-efficiently, although additional ultrasound may also result in higher false positive findings. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5027.
Author's reply to McKinley
Authors: H. Angus-Leppan
Journal: BMJ (2014)

It is correct to highlight the importance of identifying cardiac arrhythmias, and of performing electrocardiography (ECG) in all patients with transient loss of consciousness.1 The review contained a typographical error, which has now been corrected.2 ECG (not electroencephalography) is indeed mandatory for the identification of potentially fatal arrhythmias in all patients with transient loss of consciousness. At our institution, we have identified an …
Malignant Diaphragmatic Pheochromocytoma
Authors: THIERRY JACOB, JEAN M. LESCOUT, EMMANUEL BUSSY
Journal: Clinical Nuclear Medicine (2002)

From the Hôpital d’Instruction des Armées Sainte Anne, Toulon Naval, France Received for publication September 27, 2001. Revision accepted March 25, 2002. Reprint requests: Jean M. Lescout, Service de Médecine Nucléaire, H.I.A. Sainte Anne (French Navy Hospital), 83800 Toulon Naval, France.
Abstract 2119: Silencing of KCNJ2, a potassium influx channel, increases cisplatin-induced cell death in oral cancer.
Authors: Yen Liang Li
Journal: Cancer Research (2013)

Abstract Oral cancer is the sixth leading cancer in the world. Cisplatin is the first-line of chemotherapeutic drug for the treatment of oral cancer, however, cancer with cisplatin resistance is a significant cause of treatment failure. To investigate the mechanism of cisplatin resistance, we established cisplatin-resistant (CR) subline cells from SAS, CGHNC8, and CGHNC9 oral cancer cell lines. The transcriptomic profiling analysis was performed between parental and CR subline cells to global survey and identify cisplatin-resistant genes. Total of 345 genes were differentially expressed in both SAS and CGHNC8 cells, in which 16 genes were confirmed. KCNJ2 was shown highest over-expression in both CR subline cells, and was selected for further investigation. KCNJ2 is a molecular potassium influx channel, which allows potassium flowing into cells to maintain ion homeostasis. To determine potential effect of KCNJ2, we have established KCNJ2 stable knocked down cells. Results showed that KCNJ2 knockdown cells were more sensitive to cisplatin treatment, as demonstrated by significantly reduced potassium influx, accelerated apoptosis by increasing caspase activity, and led to reduced cellular clonogenic survival. Taking together, we have profiled transcriptomes and identified at least 16 genes which may associate with cisplatin resistance in oral cancer cells. KCNJ2 silencing sensitizes cisplatin-resistant cells, through suppression of potassium influx. This study serves as knowledge foundation for clinical application in the prediction or prognosis of cisplatin treatment for oral cancer. Citation Format: Yen Liang Li. Silencing of KCNJ2, a potassium influx channel, increases cisplatin-induced cell death in oral cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2119. doi:10.1158/1538-7445.AM2013-2119
Etanercept-Induced Sarcoidosis in Rheumatoid Arthritis
Authors: Reiko Nakajima, Koichiro Abe, Ayako Nakajima, Toshio Nishikawa, Shuji Sakai
Journal: Clinical Nuclear Medicine (2014)

We report the F-FDG PET/CT findings of an etanercept-induced sarcoidosis in a patient with rheumatoid arthritis. A 68-year-old woman with rheumatoid arthritis who had been treated with etanercept and methotrexate showed multiple lung nodules and hilar lymph node swellings on CT. She underwent FDG PET/CT for cancer screening. Intense FDG uptakes were found in the multiple lung nodules, bilateral hilar lymph nodes, a periurethral masslike lesion, and cranial meningeal nodules. A histopathological examination revealed epithelioid granuloma with multinucleated giant cells, which was compatible with sarcoidosis.
Successful Chemoprophylaxis for<i>Pneumocystis carinii</i>Pneumonitis
Authors: Walter T. Hughes, Shirley Kuhn, Subhash Chaudhary, Sandor Feldman, Manuel Verzosa, Rhomes J.A. Aur, Charles Pratt, Stephen L. George
Journal: New England Journal of Medicine (1977)

In a randomized, double-blind, placebo-controlled study to evaluate the efficacy of trimethoprim–sulfamethoxazole for the prevention of Pneumocystis carinii pneumonia, we studied 160 patients with cancer who were at high risk for this pneumonia over a two-year period. Seventeen of the 80 patients receiving a placebo acquired P. carinii pneumonitis, whereas none of the 80 given 150 mg of trimethoprim and 750 mg of sulfamethoxazole per square meter per day had the infection (P<0.01). Bacterial sepsis, pneumonia other than that caused by P. carinii, acute otitis media, upper-respiratory-tract infections, sinusitis and cellulitis occurred less frequently in recipients of the drug than in the placebo group (P<0.01 in each case). Oral candidiasis was the only adverse effect encountered from trimethoprim–sulfamethoxazole administration. The study shows the combination to be highly effective in the prevention of P. carinii pneumonitis. (N Engl J Med 297:1419–1426, 1977)
834 BOCEPREVIR IS ASSOCIATED WITH DECLINE IN RENAL FUNCTION IN A COHORT OF HCV-TREATED PATIENTS
Authors: L. Kapelusznik, A.M. Majid, E.R. Cox, E. Funk, Y. Flores, B. Charon, J. Myers, C. Dickson, R.G. Knodell, S. El-Kamary, R. Talwani
Journal: Journal of Hepatology (2013)