tbuckley/cabot-search huggingface dataset:
PTH-225 Paediatric malnutrition screening on admission: a comparison of different tools and their association with body composition and clinical outcomes: Abstract PTH-225 Table 1
Authors: NE Lara Pompa, J Williams, S Macdonald, K Fawbert, J Valente, K Kennedy, V Shaw, JC Wells, S Hill, M Fewtrell
Journal: Gut (2015)

<h3>Introduction</h3> The aim of the study was to evaluate associations between currently available paediatric malnutrition screening tools (MSTs), baseline body composition (BC) measurements and clinical outcomes (length of stay-LOS; nutrition status on discharge-NS) in children admitted to a tertiary referral hospital. <h3>Method</h3> 128 children (mean age 10.7yr; 49.2% male; 54.7% surgical) admitted to Great Ormond Street Hospital (GOSH) under any specialty and expected stay &gt;3 days were enrolled. 3 MSTs (Paediatric Yorkhill Malnutrition Score-PYMS; Screening Tool for the Assessment of Malnutrition in Paediatrics-STAMP; Screening Tool for Risk of Impaired Nutritional Status and Growth-STRONG) were implemented on admission. Weight (WT) and BC measurements (lean (LM) and fat mass (FM) by dual Energy X-ray Absorptiometry) were obtained within 48 h of admission and SD scores (SDS) calculated from UK BC reference data.<sup>1</sup>WT and LOS were recorded on discharge. <h3>Results</h3> STAMP classified more patients as high risk (HR) compared to PYMS and STRONG. Most patients were identified as moderate risk (MR) by both STAMP and STRONG, and low risk (LR) by PYMS. STAMP and STRONG classified more surgical patients in HR and MR categories respectively. STAMP and STRONG showed the best agreement (60.9% agreement, 0.427 kappa), followed by STRONG and PYMS (48.4% agreement; 0.321 kappa) and STAMP and PYMS (46.1% agreement; 0.284 kappa). Children classified HR by STRONG had significantly lower WT, LM and FM SDS compared to LR and MR patients. The HR category in STAMP also had significantly lower LM SDS. MSTs did not correlate significantly with LOS and discharge NS (WT change), although there was a tendency for HR patients to stay longer than predicted. <h3>Conclusion</h3> STAMP and STRONG seem to show the best agreement, and identify HR patients with abnormal BC (especially low LM). GOSH patients are generally short and have multiple and chronic diagnoses, possibly explaining the proportion of patients classified as LR by PYMS, which used body mass index scores and does not consider underlying diagnosis. Although HR patients showed a tendency for worse clinical outcomes, these were not significant, probably reflecting the limitations of these generic outcomes for this heterogeneous group. Thus, further research is needed in specific patient groups to establish the usefulness of each MST in different conditions. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Wells JC <i>et al</i>. AJCN 2012;96:1316–26
Depression as expressed in pre-Columbian Mexican art
Authors: J R de la Fuente, D Alarcón-Segovia
Journal: American Journal of Psychiatry (1980)

While undertaking a larger study dealing with representations of disease in pre-Columbian ceramic figures, the authors found four figures in which depression was clearly depicted. Their findings prove that psychiatric disorders did not go unnoticed by the people who inhabited the American continent before the arrival of the Spanish.
Reply
Authors: Teresa Antonia Santantonio, Massimo Fasano, Evangelista Sagnelli
Journal: Hepatology (2014)

We thank Dr. C-Y Dai and colleagues for their interest in our study1 and their stimulating comments. In the Letter to the Editor, they reported that in chronic hepatitis C patients enrolled in randomized controlled trials, a rapid virological response (RVR) in genotype 2-infected patients and an RVR with a low baseline viral load for genotype 1-infected patients permitted a shorter treatment.2, 3 In our study on acute hepatitis C (AHC) patients, RVR was the only predictive factor for sustained virological response (SVR), regardless of HCV genotype, baseline viral load, and treatment regimen. In AHC-patients without RVR a 24-week course of pegylated-interferon (Peg-IFN) did not increase the chance of SVR compared to the 12-week course of Peg-IFN with or without ribavirin. However, we did not analyze the influence of SVR on on-treatment viral kinetics combined with other viral or host factors, including IL28B genotype, as suggested by Dr. Dai and colleagues. We agree that further studies for earlier identification of IFN nonresponder AHC patients are necessary. Teresa Antonia Santantonio, M.D.1 Massimo Fasano, M.D.1 Evangelista Sagnelli, M.D.2 1Department of Clinical and Experimental Medicine Infectious Diseases University of Foggia Foggia, Italy 2Department of Public Medicine Infectious Diseases Second University of Naples Naples, Italy
On the Discreteness of the Phases of the Cell Cycle
Authors: Stanley E. Shackney
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article On the Discreteness of the Phases of the Cell Cycle Get access Stanley E. Shackney, M.D. Stanley E. Shackney, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 4, October 1975, Pages 827–829, https://doi.org/10.1093/jnci/55.4.827 Published: 01 October 1975 Article history Received: 27 May 1975 Accepted: 27 May 1975 Published: 01 October 1975
Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis
Authors: Egon Urgard, Annely Lorents, Mariliis Klaas, Kärt Padari, Janeli Viil, Toomas Runnel, Kent Langel, Külli Kingo, Eric Tkaczyk, Ülo Langel, Toivo Maimets, Viljar Jaks, Margus Pooga, Ana Rebane
Journal: Journal of Controlled Release (2016)
C-Type Virus Particles in a Reptilian Tumor2
Authors: P. D. Lunger, W. D. Hardy, F. Clark
Journal: JNCI Journal of the National Cancer Institute (1974)

Examination of a corn snake rhabdomyosarcoma by thin-section electron microscopy revealed particles morphologically resembling C-type viruses of avian and mammalian origin. The observation extended the range of animals among which C-type particles are directly associated with tumor tissues to include a poikilothermic vertebrate for the first time.
Joint Diseases of Laboratory Animals&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Sokoloff, Leon
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Joint Diseases of Laboratory Animals Get access Leon Sokoloff, M.D. Leon Sokoloff, M.D. Laboratory of Pathology and Histochemistry, National Institute of Arthritis and Metabolic Diseases,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 5, May 1958, Pages 965–977, https://doi.org/10.1093/jnci/20.5.965 Published: 01 May 1958
Hypersensitivity to Clinically Useful Alkylating Agents and Radiation in Poly(ADP-ribose) Polymerase-Deficient Cell Lines
Authors: S Chatterjee, M F Cheng, N A Berger
Journal: Cancer Communications (1990)

Mutant V79 Chinese hamster cell lines, deficient in poly(ADP-ribose) polymerase activity, were previously shown to be significantly resistant to etoposide, a topoisomerase II inhibitor, and hypersensitive to camptothecin, a topoisomerase I inhibitor (Chatterjee, S.; Trivedi, D.; Petzold, S.J.; Berler, N.A. Mechanism of epipophyllotoxin-induced cell death in poly(adenosine diphosphate-ribose) synthesis-deficient V79 Chinese hamster cell lines. Cancer Res. 50:2713-2718, 1990 and Chatterjee, S.; Cheng, M.F.; Trivedi, D.; Petzold, S.J.; Berger, N.A. Camptothecin hypersensitivity in poly(adenosine diphosphate-ribose) polymerase-deficient cell lines. Cancer Commun. 1:389-394; 1990). We have now demonstrated hypersensitivity of these mutant cell lines, designated ADPRT 54 and ADPRT 351, to a variety of antitumor agents including melphalan, BCNU, mitomycin, and bleomycin. They are also hypersensitive to UV- and x-irradiation. These mutants, however, are significantly resistant to the topoisomerase II-targeted DNA intercalators, Adriamycin and m-AMSA. Our results strongly suggest that inhibition of poly(ADP-ribose) polymerase could be useful to potentiate the cytotoxicity of a variety of currently available antitumor drugs.
Interferon-α as adjuvant therapy for melanoma: An individual patient data meta-analysis of randomised trials
Authors: K. Wheatley, N. Ives, A. Eggermont, J. Kirkwood, N. Cascinelli, S. N. Markovic, B. Hancock, S. Lee, S. Suciu
Journal: Journal of Clinical Oncology (2007)

8526 Background: Many randomised trials have evaluated the role of adjuvant interferon-a (IFN) in high-risk melanoma, some suggesting benefit and others not. To assess the totality of current evidence, an individual patient data (IPD) meta-analysis of all available trials was performed. Methods: Standard IPD meta-analysis methods were used to assess event-free (EFS) and overall survival (OS), with odds ratios (OR) and 95% confidence intervals (CI) calculated. Trials were divided by dose of IFN - high (20 MU/m 2 ), intermediate (5–10 MU), low (3 MU) and very low (1 MU). Subgroup analyses by patient age, gender and disease characteristics were also performed. Results: IPD was provided for 10 of 13 reported trials of IFN vs. no IFN (for the other 3 trials published data were used). 6067 patients (IPD available for 85%) were included in the analysis, with over 3,700 and 3,000 events for EFS and OS. There was statistically significant benefit for IFN for both EFS (OR=0.87, CI=0.81–0.93, p=0.00006) and OS (0.9, 0.84–0.97, p=0.008). There was no evidence of differences according to dose (Table 1; trend p&gt;0.1) or duration of IFN. This proportional survival advantage translates into an absolute benefit of about 3% (CI 1%-5%) at 5 years. The effect of IFN did not differ with age, gender, tumor site, Breslow thickness, clinical nodes or disease stage. Only for ulceration was there some evidence of an interaction (p=0.03); patients with ulcerated tumors had greater benefit from IFN (EFS: OR=0.76, OS: OR=0.77) than those with no ulceration (EFS: OR=0.94, OS: OR=0.98). Conclusions: This meta-analysis provides evidence that adjuvant IFN significantly reduces the risk of relapse and improves overall survival, although the absolute survival benefit is relatively small. This analysis does not however, clarify the optimal (high, intermediate or low) dose of IFN. Given the large number of subgroup analyses performed, the apparent increased benefit in patients with ulceration requires confirmation. No significant financial relationships to disclose.
Hodgkin's disease failures: incorporating radiotherapy and high-dose treatment.
Authors: H M Prince, A Wirth, M Wolf
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.8.3022 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9256147 Hodgkin's disease failures: incorporating radiotherapy and high-dose treatment. H M PrincexH M PrinceSearch for articles by this author , A WirthxA WirthSearch for articles by this author , M WolfxM WolfSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.8.3022 PDF "Hodgkin's disease failures: incorporating radiotherapy and high-dose treatment.." Journal of Clinical Oncology, 15(8), pp. 3022–3023© 1997 by American Society of Clinical Oncology
Advances in the development of biomarkers for epilepsy
Authors: Asla Pitkänen, Wolfgang Löscher, Annamaria Vezzani, Albert J Becker, Michele Simonato, Katarzyna Lukasiuk, Olli Gröhn, Jens P Bankstahl, Alon Friedman, Eleonora Aronica, Jan A Gorter, Teresa Ravizza, Sanjay M Sisodiya, Merab Kokaia, Heinz Beck
Journal: The Lancet Neurology (2016)
The Histogenesis of Virus-Induced Chicken Leukemia&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Jan Pontén, Bo Thorell
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article The Histogenesis of Virus-Induced Chicken Leukemia Get access Jan Pontén, Jan Pontén Department of Pathology, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Bo Thorell Bo Thorell Department of Pathology, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 3, March 1957, Pages 443–453, https://doi.org/10.1093/jnci/18.3.443 Published: 01 March 1957 Article history Received: 21 November 1956 Published: 01 March 1957
Characteristics of psychotic inpatients with high or low HVA levels at admission
Authors: M B Bowers
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to examine the clinical profiles of psychotic patients whose fasting levels of plasma free homovanillic acid (HVA) were elevated on the day after admission to the hospital.These 85 subjects with nonorganic psychoses had been previously studied with respect to their response to neuroleptic treatment. They were divided into two groups on the basis of a median split of their pretreatment plasma HVA levels, and the two groups were compared on a number of clinical and demographic variables ascertained during their hospital stay. Fasting levels of plasma free HVA and 3-methoxy-4-hydroxyphenylglycol (MHPG) were measured by gas chromatography-mass spectrometry.The high-HVA group tended to show a better prognostic profile than the low-HVA group; however, the only significant difference between groups was in the greater use of psychotogenic drugs by low-HVA males. Fourteen additional psychotic patients with distinctly elevated HVA levels and normal MHPG values were also diagnostically heterogeneous.The results suggest that psychotic patients with different diagnoses who have relatively high levels of plasma free HVA before treatment will show a favorable early response to neuroleptic drugs. There may be neurobiological processes linking some patients across the clinical spectrum of the psychotic disorders.
PTH-352 Selective extra levator versus standard abdominoperineal resection - experience from a tertiary care centre
Authors: V Pai, KC Vallam, A Tamhankar, A Desouza, S Arya, P Patil, R Engineer, AP Saklani
Journal: Gut (2015)

<h3>Introduction</h3> Comparison of Extralevator abdomino perineal resection [ELAPER] with conventional Abdominoperineal resection[APER] with regard to short term oncological and clinical outcomes. <h3>Method</h3> Patients with low rectal cancer who underwent abdomino perineal resection in TMH during the time period from July 2013 to January 2015 were included. Decision to perform ELAPER was based on levator involvement, with APER being performed in those with levators free. Short term oncological outcomescomparedincluded CRM, tumour site perforation [TSP] and number of nodes dissected. Clinical outcomes compared included post-operative perineal wound complications, need for plastic reconstruction and hospital stay. <h3>Results</h3> One hundred twenty patients with low rectal cancers underwent abdomino perineal resection during the defined study period. Out of these forty had undergone ELAPER. Both groups were comparable in the baseline characteristics except levator involvement which was significantly higher in ELAPER group. CRM involvement was seen in 8.75% with APER compared to 5% with ELAPER. Median blood loss was 400 ml with APER compared to 500 ml with ELAPER. Plastic reconstruction was required in 5% of APR and 17.5% of ELAPER. <h3>Conclusion</h3> Selective use of ELAPER is warranted in cases of low rectal cancer particularly when levators are involved by the tumour on MRI. <h3>Disclosure of interest</h3> None Declared.
PTH-234 Nanosheet with pla is a novel material for the prevention of postoperative adhesion formation
Authors: N Yabe, K Okabayashi, M Tsuruta, S Murai, H Hasegawa, Y Kitagawa
Journal: Gut (2015)

<h3>Introduction</h3> Intra-abdominal adhesion formation is the main cause of intestinal obstruction and chronic abdominal pain. Although several anti-adhesive agents have been applied to reduce the burden of adhesion-related symptoms, their operability is a major drawback. Nanosheets with PLA which comprise of thin membrane has a great operability and adheres well to the surface of intra-abdominal organs. Therefore, nanosheets with PLA therefore, is considered one of the novel promising anti-adhesive agents. The aim of this study is to evaluate the impact of Nanosheets with PLA on the prevention of intra-abdominal adhesion formation. <h3>Method</h3> For the induction of intra-abdominal adhesion, peritoneal defects were created on each side of abdominal wall of C57/BL mice (9 to 10 weeks old) and were covered by anti-adhesive agents (Nanosheets with PLA vs. sodium hyaluronate/carboxymethylcellulose vs. none). The incidence and severity of adhesion were compared within three groups using chi-square test. The infiltration of inflammatory cells was assessed by immunohistochemistry. <h3>Results</h3> Mean adhesion scores of nanosheets with PLA, sodium hyaluronate/carboxymethylcellulose or none were 1.0 ± 0.00, 1.4 ± 0.56 and 4.2 ± 0.51, respectively. A significant difference was observed in two comparisons between none and anti-adhesive agents whilst there was no significant difference between anti-adhesive agents. These findings revealed that both anti-adhesive agents could significantly reduce postoperative adhesion formation and the protective effects were comparable between two agents. The infiltration of inflammatory cells (macrophages and T cells) around peritoneal defect was reduced in Nanosheets with PLA, compared with sodium hyaluronate/carboxymethylcellulose. <h3>Conclusion</h3> The anti-adhesive effect of nanosheets with PLA was comparable with conventional anti-adhesive agents, such as sodium hyaluronate/carboxymethylcellulose. These protective effects were expectedly obtained through the prevention of direct adhesion to adjacent tissues and the reduced local inflammation. <h3>Disclosure of interest</h3> N. Yabe Grant/Research Support from: Toray Industries, Inc., K. Okabayashi Grant/Research Support from: Toray Industries, Inc., M. Tsuruta Grant/Research Support from: Toray Industries, Inc., S. Murai: None Declared, H. Hasegawa Grant/Research Support from: Toray Industries, Inc., Y. Kitagawa Grant/Research Support from: Toray Industries, Inc.
A Phase-Contrast Microscope Study of Free Cells Native to the Peritoneal Fluid of DBA/2 Mice
Authors: Marie D. Felix, A. J. Dalton
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article A Phase-Contrast Microscope Study of Free Cells Native to the Peritoneal Fluid of DBA/2 Mice Get access Marie D. Felix, Marie D. Felix National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. J. Dalton A. J. Dalton National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 2, October 1955, Pages 415–445, https://doi.org/10.1093/jnci/16.2.415 Published: 01 October 1955 Article history Received: 11 March 1955 Published: 01 October 1955
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis
Authors: Andrea Cipriani, Xinyu Zhou, Cinzia Del Giovane, Sarah E Hetrick, Bin Qin, Craig Whittington, David Coghill, Yuqing Zhang, Philip Hazell, Stefan Leucht, Pim Cuijpers, Juncai Pu, David Cohen, Arun V Ravindran, Yiyun Liu, Kurt D Michael, Lining Yang, Lanxiang Liu, Peng Xie
Journal: The Lancet (2016)
Self-Portrait
Authors: Kristen M. Quaranta
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SAT0573 Clinical and Treatment Patterns in Early Psoriatic Arthritis: Comparison with Early Rheumatoid Arthritis in a Recent Onset Arthritis Cohort: Table 1
Authors: M.D. Peiteado Lopez, L. Nuño, A. Villalba, G. Bonilla, K. Franco, C. Plasencia, P. Aguado, A. Balsa, E. Martin-Mola
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> The aim of the study was to analyse baseline clinical patterns of early psoriatic arthritis (PsA), and to compare this patterns with early rheumatoid arthritis (RA) both from an early arthritis clinic (EAC). As a secondary objective we analysed differences in outcomes and therapy. <h3>Methods</h3> We studied 1102 patients from our EAC and included all patients who were diagnosed as PsA or RA after 2 years follow-up. We collected demographic and clinical characteristics at baseline as: joint involvement, symmetry, sex, age and smoking habit. Clinical and laboratory assessments included morning stiffness, joint pain, patient and physician global assessment (PtGA, PhGA), tender (TJC) and swollen joint count (SJC), HAQ, DAS28, SDAI, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF), anti-citrullinated peptide antibodies (ACPA) and therapy <h3>Results</h3> Sixty-four patients with a final diagnosis of PsA were included and were compared with 483 patients with a definite diagnosis of RA. Thirty-five patients (54.7%) were male and the mean age was 56.5±13.2 years. The initial pattern was oligoarticular, polyarticular and monoarticular in 50%, 36% and 14% of patients, respectively. Most of them had a subacute onset (53, 82.8%) and 11 (18.2%) had an acute onset. Joint involvement was symmetrical or asymmetrical in similar percentages. At baseline, PsA patients have more frequently a mono or oligoarticular pattern as compared to RA (64% vs 18%, respectively, p&lt;0.01) and were less frequently symmetrical (51.5% vs 88%, p&lt;0.01). Less PsA patients were women (45.3% vs 78% p&lt;0.01) and were younger (56±13.2 vs 61.3±17.7 years, p&lt;0.01). No differences in smoking habit or the type of involvement (acute vs subacute) were found. Clinical characteristics at baseline and after 2 years follow-up are shown in table. There were significant differences in ACCP and RF between both groups, without differences in ESR and CRP. A lower percentage of PsA patients used Methotrexate as compared to RA patients (75% vs. 90.4%, p&lt;0.01), and a higher percentage used sulfasalazine (15.6% versus 7.4% p=0.05), mainly in patients with axial involvement, with no differences in the use of leflunomide. <h3>Conclusions</h3> In this early arthritis cohort of PsA patients, clinical involvement at baseline was significantly different from RA patients. Disease activity and disability was lower in patients with PsA as compared with RA both at baseline and after 2 years follow-up. <h3>Disclosure of Interest</h3> None declared