tbuckley/cabot-search huggingface dataset:
The Physician Quality Reporting Initiative
Authors: Jay A. Harolds, Janette K. Merrill
Journal: Clinical Nuclear Medicine (2011)

The physician quality reporting initiative (PQRI) is a voluntary program for reporting certain quality measures on Medicare patients in return for receiving a small bonus payment. However, the PQRI procedures are such that a large number of those who try to participate do not receive incentive payments. Also, many indicate that the small bonus for participation is not worth the effort and costs incurred. Furthermore, it has been found that many of the quality measures are not a good indicator of a favorable outcome, and do not clearly promote significant increases in the quality of patient care. However, penalties will be given from the year 2015 for not participating in PQRI. Also, it is expected that PQRI will be a precursor to Pay for Performance legislation, which will require mandatory participation by physicians. Therefore, participation in PQRI now is recommended by many experts, so that health care professionals can learn the procedures and make necessary adjustments in their practice procedures.
A PILOT STUDY OF A MODIFIED BATHROOM SCALE TO MONITOR CARDIOVASCULAR HEMODYNAMIC IN PREGNANCY
Authors: Odayme Quesada, Mohamed El Banani, James Heller, Shire Beach, Mozziyar Etemadi, Shuvo Roy, Omer Inan, Juan Gonzalez, Liviu Klein
Journal: Journal of the American College of Cardiology (2016)
Tips for a Physician in Getting the Right Job, Part XV
Authors: Jay Harolds
Journal: Clinical Nuclear Medicine (2014)

The interview is usually a major determinant on whether or not a physician job applicant is hired. This article addresses a number of fine points for the interview not previously emphasized in this series of articles. For example, the job candidate needs to be careful that the questions he/she asks are not negative and show respect and sensitivity to the interviewer. Some types of questions should not generally be asked. One technique to get at information is to use neutral open-ended questions. The importance of personal observations is emphasized. However, if the interview does not seem to be going well, the candidate may want to directly address that. The spouse should also ask appropriate questions regarding the community and not reveal information on certain subjects such as how many other offers the job hunter has and any reservations they have regarding the job or the area.
Technetium-99m HMPAO Labeled Leukocytes as the Primary Diagnostic Tool in a Case of Brain Abscess
Authors: PHILIP R. SABA, KATHLEEN McDONALD, JONATHAN HUNN, KHURSHED DASTUR, VINOD CHABLANI
Journal: Clinical Nuclear Medicine (1997)

The authors present a case in which Tc-99m HMPAO labeled autologous leukocytes were used to demonstrate a brain abscess in a patient undergoing evaluation for fever of unknown origin. The abscess was demonstrated on both 1-hour and 24-hour images. The positive 1-hour image led to CT and MRI studies, which are included for correlation. In addition to its previously identified role as a secondary diagnostic test in the differentiation of tumor and abscess, the authors propose that Tc-99m HMPAO is useful as a primary diagnostic tool in the identification of brain abscess. Furthermore, the authors suggest that Tc-99m HMPAO is preferable to In-111 labeled leukocytes because of its better resolution and earlier imaging characteristics.
Phylodynamics with Migration: A Computational Framework to Quantify Population Structure from Genomic Data
Authors: Denise Kühnert, Tanja Stadler, Timothy G. Vaughan, Alexei J. Drummond
Journal: Molecular Biology and Evolution (2016)

When viruses spread, outbreaks can be spawned in previously unaffected regions. Depending on the time and mode of introduction, each regional outbreak can have its own epidemic dynamics. The migration and phylodynamic processes are often intertwined and need to be taken into account when analyzing temporally and spatially structured virus data. In this article, we present a fully probabilistic approach for the joint reconstruction of phylodynamic history in structured populations (such as geographic structure) based on a multitype birth–death process. This approach can be used to quantify the spread of a pathogen in a structured population. Changes in epidemic dynamics through time within subpopulations are incorporated through piecewise constant changes in transmission parameters. We analyze a global human influenza H3N2 virus data set from a geographically structured host population to demonstrate how seasonal dynamics can be inferred simultaneously with the phylogeny and migration process. Our results suggest that the main migration path among the northern, tropical, and southern region represented in the sample analyzed here is the one leading from the tropics to the northern region. Furthermore, the time-dependent transmission dynamics between and within two HIV risk groups, heterosexuals and injecting drug users, in the Latvian HIV epidemic are investigated. Our analyses confirm that the Latvian HIV epidemic peaking around 2001 was mainly driven by the injecting drug user risk group.
Abstract 1524: M402, a novel heparan sulfate mimetic, inhibits pancreatic tumor growth and desmoplasia potentially via sonic hedgehog signaling in an orthotopic mouse model
Authors: Chia Lin Chu, Alison Long, Christopher M. Honan, Jay Duffner, William Avery, Josephine D'Alessandro, Takashi K. Kishimoto, Birgit C. Schultes
Journal: Cancer Research (2012)

Abstract One of the hallmarks of pancreatic ductal adenocarcinoma (PDAC) is extensive desmoplasia in the surrounding tumor microenvironment that prevents delivery of chemotherapeutics (such as gemcitabine). Dysregulation of sonic hedgehog (SHH, a heparin-binding morphogen), has been implicated in pancreatic cancer tumorigenesis. We have rationally designed a heparan sulfate mimetic, M402, that has previously been shown in animal studies to reduce metastatic seeding through disruption of several key heparin-binding growth factors (including FGF2, VEGF, SDF-1α and P-Selectin). We hypothesized that M402, alone or in combination with gemcitabine, could potentially modulate tumor-stroma interactions in an orthotopic pancreatic cancer model (Capan-2 cell line) which secretes SHH and displays a desmoplastic response in vivo. Capan-2 human adenocarcinoma cells (∼1x106 cells) were injected into the pancreata of immunodeficient mice (Nu/Nu CD-1). M402 (10-40 mg/kg/day) or saline treatment commenced on Day 4 or 32. Gemcitabine (30-60 mg/kg, twice weekly, IP) treatment commenced between Weeks 3-6. At the termination of each study (Week 8), gross anatomical observations were made of the primary pancreatic tumor and metastatic lesions in the surrounding tissues including the spleen, intestines and liver. Gemcitabine was increasingly less effective when started at later time points, but still reduced the primary tumor weight by 60-70% (at 30-45 mg/kg) when treatment was started at week 5. While the addition of M402 to gemcitabine showed some additive effect on primary tumor burden, metastasis, invasion, and surrounding fibrotic lesions appeared particularly impacted by the combination treatment. M402 was also effective as monotherapy showing a dose-dependent reduction in primary tumor weight and fibrotic lesions. Immunohistochemical and qPCR analyses showed reduced fibrosis and SHH signaling with M402 and gemcitabine combination treatment. These results demonstrate that M402 can modulate tumor-stroma interactions involved in the desmoplastic response in a murine model of pancreatic cancer and provide a rationale for the clinical investigation of M402 as a potential anti-desmoplastic agent in pancreatic cancer therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1524. doi:1538-7445.AM2012-1524
AB0817 Prospective Study in Patients with Osteoporosis: Adherence and Persistence with Antiosteoporotic Drugs
Authors: N. Toroptsova, O. Nikitinskaya
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Numerous studies have demonstrated inadequate adherence and persistence to prescribed therapies for many chronic diseases. Osteoporosis is one of the chronic medical conditions that require prolonged treatment. Poor persistence to therapy in osteoporotic patients resulting in increased risk of fracture. <h3>Objectives</h3> To evaluate adherence and persistence with drug therapy in osteoporotic patients during 3 years. <h3>Methods</h3> We conducted a prospective study of 134 osteoporotic women (mean age 64±10 years), who visited Research Institute of Rheumatology in 2010. Subjects had not received antiosteoporotic medications in the year prior to the start of the study. They were followed up every 12 months during 3 years by telephone contact for self-reporting about antiosteoporotic treatment. <h3>Results</h3> Only 99 (74%) women started the drug treatment. 36 (27%) patients were persisted less than 6 months, 23 (17%) - 12 months, 16 (12%) – 2 years and 24 (18%) – 3 years. 35 (26%) patients never began antiosteoporotic treatment. Among subjects who start the treatment 24% received alfacalcidol, 20% - calcitonin, 12% - ibandronate, 10% - alendronate and stroncium ranelate, 9% zoledronic acid and 7% - risedronate or only supplements of calcium and vitamin D. Mean persistence was 2.4, 1.7, 1.6, 2.1, 1.6, 2.2, 1.1 years for alfacalcidol, calcitonin, ibandronate, alendronate, stroncium ranelate, zoledronic acid and risedronate, respectively. 18% women were switched from one antiosteoporotic medication to another due to side effects, inconvenient dose regimen or the price of medication. Discontinuers were less likely than persistent subjects to visit physician and BMD measurement each year for control of treatment (p&lt;0.05). 7 (5%) patients had fractures during 3-years period, among them 5 women without any antiosteoporotic therapy, 1 – received only supplements of calcium and vitamin D and 1 – calcitonin. <h3>Conclusions</h3> Our study showed that less than 1/2 of patients received antiosteoporotic drugs during one year and less than 1/5 - three years. Visits to the physician and BMD measurements increased subject9s persistence. To improve the quality of medical care to OP patients physicians have to educate and motivate them for a long-term treatment to reduce risk of fractures. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4264
Quantitative Immunoelectrophoretic Analysis of Rat Allergen Extracts
Authors: Andrew F. Walls, Joan L. Longbottom
Journal: Allergy (1983)

Crossed immunoelectrophoresis reference patterns were established for the antigenic constituents of rat fur, urine and saliva. Using quantitative immunoelectrophoretic techniques, extensive cross‐reactivity was observed between these extracts, and with epithelia, shaved pelt, serum, faeces and dust. No major qualitative sex differences were observed, though levels of certain components differed. Constitutents of many source materials were found to show a reaction of partial identity with previously isolated rat urinary allergens; and relative skin test reactivity of a range of these extracts was associated with the amount of urinary allergen present. Material from two different rat strains had similar constituents. Rat source materials did not cross‐react with the corresponding extracts from guinea pigs.
P802 PORTAL HYPERTENSION DUE TO OUTFLOW BLOCK IN NON-CIRRHOTIC PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Authors: Y. Koizumi, M. Hirooka, H. Ochi, F. Tada, T. Miyake, Y. Tokumoto, A. Hiraoka, M. Abe, B. Matsuura, Y. Hiasa
Journal: Journal of Hepatology (2014)
OC-072 Are surgeons a positive or negative influence on the HPN population?
Authors: R F Mckee
Journal: Gut (2012)

<h3>Introduction</h3> The aim of this study was to establish the number of patients in whom surgery led to Home Parenteral Nutrition (HPN) in comparison to the number in whom surgery led to stopping HPN. <h3>Methods</h3> Data relating to HPN patients has been collected prospectively in our hospital since 2000 as part of the Scottish Managed Clinical Network for HPN. Data held include demographics, underlying disease, previous surgery, and start and stop dates for HPN with the underlying reasons. This data was analysed in January 2011. <h3>Results</h3> Sixty eight patients (26M: 42F; median age at start 53 years: range 16–78 years) had HPN supervised by our hospital during 11 years. The underlying disease was Crohn9s disease in 26 patients, mesenteric ischaemia in 12 patients, malignancy in seven patients, motility disorders in eight patients, radiation enteritis in seven patients and other in 13 patients. Seven patients started HPN prior to 2000. Between 2000 and 2011, 61 patients started HPN and 35 patients stopped. Forty-three patients started HPN following gastrointestinal surgery and in 20 of these, HPN was needed because of a surgical complication (nine small bowel fistulae; 10 intra-abdominal sepsis leading to high output stoma; one bowel obstruction). Thirty-five patients stopped HPN. Seventeen patients died – nine of the underlying disease, four of unrelated cause, two of HPN complications and two of both HPN complications and the underlying disease. Seventeen patients stopped HPN after reconstructive surgery, HPN was stopped due to complications/lack of progress in one patient and one patient stopped HPN because of more effective medical treatment. Three other patients reduced their dependence on HPN after surgery (fewer nights per week or lower volume). Of the twenty patients who had HPN because of surgical complication, ten patients stopped HPN because of further surgery, five patients have ongoing HPN with no intention for further surgery, two patients have died (one of the underlying malignancy and the other of unrelated cause) and three patients are likely to have reconstructive surgery in the future. None of the patients who came to reconstructive surgery after a period of HPN died after their surgery. <h3>Conclusion</h3> Although the complications of surgery may lead to home parenteral nutrition, surgery may also be useful in reconstruction of the GI tract and this may lead to stopping HPN. It is important that surgeons are involved in the care of HPN patients, as they may be more conscious of the possibility of reconstruction. <h3>Competing interests</h3> None declared.
SP0204 The pathogenesis of sarcoidosis
Authors: A. O’Regan
Journal: Annals of the Rheumatic Diseases (2013)

Sarcoidosis is a multisystem granulomatous disease of unclear aetiology. It is generally viewed as a Th1 mediated inflammatory disease with a prelidiction for the lung, lymph nodes and skin. There is striking genetic variations in disease prevalence and disease progression. There is a lack of prognostic markers of disease progression. This presentation will review the current paradigm of sarcoidosis pathogenesis and discuss recent advances in our understanding of the spectrum of disease phenotype and outcome. <h3>Disclosure of Interest</h3> None Declared
Heritability estimates in behavior genetics: Wasn't that station passed long ago?
Authors: Wim E Crusio
Journal: Behavioral and Brain Sciences (2012)

Abstract Charney describes several mechanisms that will bias estimates of heritability in unpredictable directions. In addition, the mechanisms described by Charney explain the puzzling fact that research in human-behavior genetics routinely reports higher heritabilities than animal studies do. However, I argue that the concept of heritability has no real place in human research anyway.
Abstract 4779: TNF-induced Cofilin 1 phosphorylation by LIMK in colorectal tumor cells
Authors: Jelena Ivanovska, Benjamin Ettle, Natalya Benderska, Saritha Chakilam, Muktheshwar Gandesiri, Elisabeth Ziesché, Arndt Hartmann, Abbas Agaimy, Thomas Fischer, Antje Gohla, Ben Fabry, Regine Schneider-Stock
Journal: Cancer Research (2011)

Abstract Objectives: Recently, we have shown that the pro-inflammatory cytokine TNF induces apoptosis in HCT116 colorectal tumor cells. Among the first apoptotic signs is a drastic change in cell morphology through modulation of the cytoskeleton. In order to identify and to characterize phosphorylation events and kinase targets associated with early cytoskeletal reorganization after TNF-treatment, we performed a peptide array screen. Methods: HCT116 tumor cells were cultured for 6h to 72 hours in either normal or TNF- conditioned medium, and radioactive labelled lysates were hybridized to a PepChip kinase full slide array for screening the phosphorylation status of over 400 proteins at over 1400 potential phosphorylation sites. For verification, cell lysates were collected and co-immunoprecipitated. The precipitated proteins were analyzed by western blotting. We verified the subcellular localization of proteins by co-immunofluorescence. Results: Pepscan array and western blotting revealed that cofilin 1 is markedly phosphorylated on Serine 3 (pCofSer3) after 24 and 48 hours of TNF-treatment. A potential up-stream kinase of cofilin is LIMK1, a serine/threonine protein kinase known to be involved in actin cytoskeleton reorganization through phosphorylation and inactivation of cofilin 1. Interaction between LIMK/Cofilin1/pCofSer3 was verified by co-immunoprecipitation and co-immunofluorescence. F-actin, cofilin1 and LIMK colocalized in membrane ruffles and lamellipodia, consistent with a cofilin-dependent actin cytoskeletal remodelling after TNF treatment. The effects were reversed by ROCK 1 inhibition. Conclusion: Our data show that TNF-treatment in HCT116 tumor cells induces the formation of a LIMK/Cofilin1/pCofSer3 protein complex that is localized in membrane ruffles and lamellipodia, suggesting that TNF-induced cytoskeletal alterations early during apoptosis are regulated through cofilin signalling. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4779. doi:10.1158/1538-7445.AM2011-4779
Racial Differences in the Use of Invasive Cardiovascular Procedures in the Department of Veterans Affairs Medical System
Authors: J Whittle, J Conigliaro, C B Good, R P Lofgren
Journal: New England Journal of Medicine (1993)

Previous studies have found racial differences in the use of invasive cardiovascular procedures, which may be due in part to the greater financial incentives to perform such procedures in white patients. In Department of Veterans Affairs hospitals, direct financial incentives affecting use of the procedures are minimized for both patients and physicians.
Traitement endoscopique des fistules anastomotiques colorectales par un système de drainage endoluminal par pression négative (EndoSponge®)
Authors: D Moussata, M Chauvenet, K Stroeymeyt, G Boschetti, G Passot, D Vaudoyer, E Cotte, S Claudel Bonvoisin, S Nancey, Y Francois, O Glehen, D Cabelguenne, PJ Valette, B Flourié
Journal: Endoscopy (2013)

Les fistules anastomotiques sont une complication fréquente (10 à 15%) des anastomoses colorectales; elles nécessitent classiquement une reprise chirurgicale avec mise en place d'une stomie. But: Evaluer prospectivement l'efficacité du système Endosponge® (BBraun, France) chez des patients porteurs d'une fistule ou abcès anastomotique post-chirurgical.
THE IMPACT OF DEMOGRAPHIC, SURGICAL AND INTENSIVE CARE UNIT FACTORS ON LONG-TERM QUALITY OF LIFE IN CONGENITAL HEART DISEASE SURGICAL SURVIVORS
Authors: Bradley Marino, Amy Cassedy, Kate Brown, Mirjana Cvetkovic, John Costello, Rodney Franklin, J. William Gaynor, Simon Laker, Katherine Levinson, Helen MacGloin, Lynn Mahony, Annette McQuillan, Kathleen Mussatto, Deirdre O’Shea, Jane Newburger, Michelle Sykes, Sarah Teele, Gil Wernovsky, Dennis Drotar, Jo Wray
Journal: Journal of the American College of Cardiology (2015)
CS-25 * MOLECULAR SUBCLASSIFICATION OF GLIOBLASTOMA BASED ON THE ABSOLUTE QUANTITATIVE PROTEOMICS
Authors: M. Nakada, W. Obuchi, S. Ohtsuki, S. Tanaka, T. Furuta, T. Kitabayashi, H. Sabit, T. Terasaki, Y. Hayashi
Journal: Neuro-Oncology (2014)

Glioblastoma (GBM) has been classified into molecular subtypes with the advent of large-scale gene expression studies. The purpose of this study is to attempt to classify GBM subtypes based on the molecular profile determined by absolute quantitative proteomics and to investigate its clinical significance. The absolute protein expression levels of 13 species of receptor tyrosine kinases (RTKs) in 33 adult GBM surgical specimens were measured by the mass spectrometer which was set up to run a multi-channel reaction monitoring. For each tumor, we ascertained information on patient age, gender, IDH1 mutation, methylation status of MGMT promoter, progression-free survival (PFS) and overall survival (OS). Eight RTK proteins (EGFR, ERBB2, PDGFRα, PDGFRβ, VEGFR1, CD33, CD37, c-kit) were successfully quantified, whereas 5 protein levels were below detection limit. Large individual differences were observed in protein expression levels of each RTK. The highest mean expression level was detected for EGFR. GBMs in our study harbored mutually exclusive dominant expression of three RTKs; EGFR, ERBB2 and PDGFRα. Therefore, we propose a subclassification of GBM with respect to the dominant expression of these proteins; EGFR (n = 20), ERBB2 (n = 7) and PDGFRα (n = 6). The clinical characteristics of each group (EGFR, ERBB2, PDGFRα) are as follows: average age, (61.9, 58.4, 56.7 years old), gender (male/female, 15/5, 4/3, 6/0), IDH1 (wild/mutant, 18/2, 6/1, 6/0), MGMT promoter (methylated/unmethylated, 8/12, 3/4, 4/2), the median progression-free survival (PFS) (7.6, 10.0, 8.6 months), the median overall survival (OS) (13.7, 21.1, 13.8 months). PFS and OS tended to be longer in ERBB2 group in comparison with EGFR and PDGFRα group. Molecular subclassification of GBM based on the absolute quantitative proteomics reflects the clinical behavior and might have clinical significance.
IN-HOSPITAL MORTALITY OF MYOCARDIAL INFARCTION BY SEX, AGE, AND OBSTRUCTIVE CORONARY ARTERY DISEASE STATUS IN THE ACTION REGISTRY-GWTG
Authors: Nathaniel R. Smilowitz, Asha Mahajan, Matthew Roe, Anne Hellkamp, Karen Chiswell, Martha Gulati, Harmony Reynolds
Journal: Journal of the American College of Cardiology (2016)
Migration of Tc-99m DTPA from the Cerebral Ventricle to the Subarachnoid Space
Authors: John A Vento, Harold Moskowitz, Richard P Spencer, Weiguo Ye
Journal: Clinical Nuclear Medicine (2002)

A 70-year-old woman was examined because of increasing problems with cognition. She had a history of a cerebral shunt placed surgically 10 years previously. Introduction of Tc-99m DTPA directly into the ventricular cavity revealed good ventricular distribution, followed by progression downward, as though into a previous ventriculoperitoneal shunt. However, a chest radiograph revealed what appeared to be a shunt tube in the right atrium. Delayed lateral images showed activity in proximity to the vertebral column, indicating migration of tracer and cerebrospinal fluid into the dorsal and lumbar subarachnoid space.
Von Willebrand's Disease
Authors: Herbert S. Strauss, Gerald E. Bloom, Margaret Butts
Journal: New England Journal of Medicine (1965)

THE bleeding disorder known as von Willebrand's disease or pseudohemophilia has been characterized by a tendency to bleeding from the mucous membranes, a prolonged bleeding time, reduced plasma level of factor VIII (antihemophilic factor) and an autosomal-dominant mode of inheritance.1 2 3 4 5 The role of platelets in the pathogenesis of this disease has remained controversial. Some investigators have found such platelet anomalies as deficiency of platelet factor 3 in the thromboplastin-generation test, abnormal morphology under the electron microscope6 7 8 9 and abnormal osmotic resistance.10 Others have been unable to confirm the presence of a defect of platelet factor 3 in this disorder.2 In view . . .