tbuckley/cabot-search huggingface dataset:
Biomarkers for cervical cancer generated by proteomic analysis of exfoliated cervical epithelial cells
Authors: Carolina Lema, John E. Wiktorowicz, Tri A. Dinh, Dat D. Dao
Journal: Cancer Research (2006)

4455   Proteomic biomarkers that either distinguish women who are at risk of developing cervical cancer or detect its precursor lesions will have significant impact on early detection and reduced mortality. Although preventable and curable if detected early, cervical cancer is still the second most common cancer in women worldwide and the leading cause of cancer-related deaths in women in developing countries where cytology screening programs have shown to be ineffective. The current use of biopsy tissue for cervical cancer biomarkers development represents a limiting factor because it is invasive and does not allow having access to a large number of specimens - not only from patients but also from healthy controls - which is critical for biomarkers discovery and validation. To address this issue, protein was isolated from a total of 24 cervical scrapings collected from women attending the OB/GYN clinics operated under the University of Texas Medical Branch at Galveston. The pool of samples included women presenting with normal cytology as well as patients with a wide spectrum of clinical diagnosis. For the purpose of the present study only patients with high-grade squamous intraepithelial lesion (HSIL) confirmed by colposcopy and/or biopsy (cases; N=4); and women with negative Pap test and no prior history of abnormal cytology (controls; N=3) were selected for two dimensional gel electrophoresis (2DGE) analysis. All three control gels were normalized to create an average control gel which was compared individually to all four cases. A total of 79 spots at least 2 folds differentially expressed were identified and selected for spot picking, trypsin digestion and peptide mass fingerprinting by matrix-assisted laser desorption ionization - time-of-flight / time-of-flight - mass spectrometry (MALDI-TOF/TOF-MS). Thirty-four (34) proteins were identified with expectation values greater than 10 −3  and were expressed either only in cases, only in controls, higher in cases or higher in controls. Among the derived proteins are members of the ovalbumin serine proteinase inhibitors, calcium-binding proteins, keratins, human actin-binding proteins, cysteine proteinase inhibitors and proteins involved in cellular glycolysis, cytokinesis, and metastasis. In addition to some previously reported protein biomarkers in biopsy specimens from cervical tumors, a subset of new biomarkers was identified in this study. Our results demonstrate the feasibility of proteomic analysis of exfoliated cervical epithelial cells as a promising tool for the development of biomarkers for cervical cancer.
Integration of cognition and emotion in physical and mental actions in musical and other behaviors
Authors: Martin Frederick Gardiner
Journal: Behavioral and Brain Sciences (2015)

Integration of cognition and emotion, discussed by Pessoa in The Cognitive-Emotional Brain (2013), is further illustrated by music. In music, I argue, this integration begins during mental control of the actions by which musical sounds are produced. Many emotional reactions to the music we hear are also strongly related to the actions by which musical sounds are produced. Studies involving music can further illuminate the integration of emotion and control of action throughout behavior.
Improved Cigarettes—Comments on the State-of-the-Art, 1971&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: D Tiggelbeck
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Improved Cigarettes—Comments on the State-of-the-Art, 1971 Get access Donald Tiggelbeck Donald Tiggelbeck Pittsburgh Activated Carbon Division, Calgon Corporation, Pittsburgh, Pennsylvania 15230 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 6, June 1972, Pages 1825–1832, https://doi.org/10.1093/jnci/48.6.1825 Published: 01 June 1972
Endoscopic ultrasound-guided transesophageal pericardiocentesis: an alternative approach to a pericardial effusion
Authors: Y. Hashimoto, K. Inoue
Journal: Endoscopy (2016)

Echocardiography-guided pericardiocentesis is a procedure commonly performed by cardiologist to evaluate pericardial effusions. It is generally considered a relatively safe procedure with minimal complications and a high success rate [1] [2] [3]. However, a safe approach to the pericardial effusion may on occasion not be possible. Endoscopic ultrasound (EUS) is capable of better visualization of the pericardium and left atrium. This is the first report to highlight the use of EUS-guided pericardiocentesis as an alternative method to the echocardiography-guided procedure.
OncodriveFML: a general framework to identify coding and non-coding regions with cancer driver mutations
Authors: Loris Mularoni, Radhakrishnan Sabarinathan, Jordi Deu-Pons, Abel Gonzalez-Perez, Núria López-Bigas
Journal: Genome biology (2016)

Distinguishing the driver mutations from somatic mutations in a tumor genome is one of the major challenges of cancer research. This challenge is more acute and far from solved for non-coding mutations. Here we present OncodriveFML, a method designed to analyze the pattern of somatic mutations across tumors in both coding and non-coding genomic regions to identify signals of positive selection, and therefore, their involvement in tumorigenesis. We describe the method and illustrate its usefulness to identify protein-coding genes, promoters, untranslated regions, intronic splice regions, and lncRNAs-containing driver mutations in several malignancies.
Observations on Gastric Atrophy After Liver Therapy
Authors: Edward B. Benedict, M. D.
Journal: JNCI Journal of the National Cancer Institute (1947)

Observations on Gastric Atrophy After Liver Therapy Get access Edward B. Benedict, M. D. Edward B. Benedict, M. D. Massachusetts General Hospital, Boston Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 321–325, https://doi.org/10.1093/jnci/7.5.321 Published: 01 April 1947
AT-11CRIBRIFORM NEUROEPITHELIAL TUMOR (CRINET): MOLECULAR CHARACTERIZATION OF A SMARCB1-DEFICIENT NON-RHABDOID TUMOR WITH FAVORABLE LONG-TERM OUTCOME
Authors: Martin Hasselblatt, Christian Thomas, Katharina Heß, Volker Hovestadt, Pascal Johann, Susanne Bens, Florian Oyen, Cynthia Hawkins, Christopher R. Pierson, Kenneth Aldape, Sang Pyo Kim, Eva Widing, David Capper, David T.W. Jones, Stefan M. Pfister, Reinhard Schneppenheim, Reiner Siebert, Werner Paulus, Michael C. Frühwald, Marcel Kool
Journal: Neuro-Oncology (2016)
Self-enhanced targeted delivery of a cell wall– and membrane-active antibiotics, daptomycin, against staphylococcal pneumonia
Authors: Hong Jiang, Meimei Xiong, Qiuyan Bi, Ying Wang, Chong Li
Journal: Acta Pharmaceutica Sinica B (2016)

Considering that some antibacterial agents can identify the outer structure of pathogens like cell wall and/or cell membrane, we explored a self-enhanced targeted delivery strategy by which a small amount of the antibiotic molecules were modified on the surface of carriers as targeting ligands of certain bacteria while more antibiotic molecules were loaded inside the carriers, and thus has the potential to improve the drug concentration at the infection site, enhance efficacy and reduce potential toxicity. In this study, a novel targeted delivery system against methicillin-resistant Staphylococcus aureus (MRSA) pneumonia was constructed with daptomycin, a lipopeptide antibiotic, which can bind to the cell wall of S. aureus via its hydrophobic tail. Daptomycin was conjugated with N-hydroxysuccinimidyl-polyethylene glycol-1,2-distearoyl-sn-glycero-3-phosphoethanolamine to synthesize a targeting compound (Dapt-PEG-DSPE) which could be anchored on the surface of liposomes, while additional daptomycin molecules were encapsulated inside the liposomes. These daptomycin-modified, daptomycin-loaded liposomes (DPD-L[D]) showed specific binding to MRSA as detected by flow cytometry and good targeting capabilities in vivo to MRSA-infected lungs in a pneumonia model. DPD-L[D] exhibited more favorable antibacterial efficacy against MRSA than conventional PEGylated liposomal daptomycin both in vitro and in vivo. Our study demonstrates that daptomycin-modified liposomes can enhance MRSA-targeted delivery of encapsulated antibiotic, suggesting a novel drug delivery approach for existing antimicrobial agents.
HG-78SYNTHETIC LETHAL EPIGENETIC INTERACTIONS IN K27M MUTATED DIPG
Authors: Sujatha Venkataraman, Nathan Davidson, Jenny Samson, Ilango Balakrishnan, Diane Birks, Irina Alimova, Vladimir Amani, Eric Prince, Andrew Donson, Jean Mulcahy-levy, Adam Green, Nalin Gupta, Rintaro Hashizume, Esther Huellman, Michelle Monje, Nicholas Foreman, Rajeev Vibhakar
Journal: Neuro-Oncology (2016)
Book: The Oath: A Surgeon Under Fire
Authors: Iain McClure
Journal: BMJ (2004)

Have you ever wondered, after a hard week at work, why you decided to become a doctor? If so, you might want to read this book. It should make any woes you might have pale into insignificance. It might also lead you to reflect on the continuing significance of the Hippocratic oath. In this gripping true story Khassan Baiev, a surgeon from Chechnya, has provided his own interpretation of Hippocrates' ancient touchstone of medical ethics. Part autobiography, part history lesson, part drama, the book is a page turner not because of its literary style (Baiev cannot speak English, and his translators have, whether by accident or design, left his somewhat naive style undoctored) but because of the horrific reality of its content.​content.




Figure 1



Khassan Baiev (with Ruth and Nicholas Daniloff)

Simon & Schuster, £17.99, pp 354 ISBN 0 7432 2011 0

Rating: ★★★




To the great Russian bear the republic of Chechnya is a troublesome tick of a nation of a million mostly Muslim people stuck in its Caucasian underbelly—a politically volatile, oil rich interface between the Muslim and Christian worlds. Chechnya's struggle for independence goes back to the 16th century, and the consequent cycle of Chechnyan resistance and Russian repression has led to some of the worst (but largely under-reported) atrocities of recent times. By 1994 political instability and consequent lawlessness in Chechnya gave the Russian president, Boris Yeltsin, the excuse he needed to invade. The attacks in the United States on 11 September 2001 provided further political cover for Yeltsin's successor, Vladimir Putin, to order a second Russian invasion in 2000, this time with overwhelming force, resulting in the levelling of the once beautiful capital, Grozny.

At the start of the first invasion in 1994 Baiev had a choice: to join the medical exodus (and pursue a lucrative career in plastic surgery in Moscow) or to remain in Grozny as a general surgeon and help the civilian population. He remained out of loyalty to his Hippocratic oath. By the peak of the second war in 2000 Baiev was the only doctor working in his home town of Alkhan Kala, which had been absorbing the devastated human exodus from Grozny. In one 48 hour period Baiev performed 74 operations (67 amputations and seven brain operations) using a blunt carpenter's saw and ordinary sewing thread. He describes shattered children and heroic pensioners. Baiev's perspective on the combatants is particularly telling. He is not partisan and dealt equally with the callousness of the Chechen fighters and that of the Russians. He was almost executed by soldiers from both sides, on several occasions. His subsequent mental health problems and his escape as a political refugee to the United States provide a further dramatic twist.

This book is a testimony to Baiev's fortitude and to the potential uniqueness of the doctor's role. As Baiev says: “War reveals a person's true character.”
CR-23CLINIOPATHOLOGICAL AND MOLECULAR CHARACTERISTICS OF PAEDIATRIC MENINGIOMAS
Authors: Anupam Kumar, Sudha Battu, Suvendu Purkit, Mehar C. Sharma, Chinmaya Dash, Ashish Suri, Manmohan Singh, Chitra Sarkar, Vaishali Suri
Journal: Neuro-Oncology (2016)

CR-23. CLINIOPATHOLOGICAL AND MOLECULAR CHARACTERISTICS OF PAEDIATRIC MENINGIOMAS Anupam Kumar1,2, Sudha Battu1, Suvendu Purkit1, Mehar C. Sharma1, Chinmaya Dash2, Ashish Suri2, Manmohan Singh2, Chitra Sarkar1, and Vaishali Suri1; Departments of Pathology All India Institute of Medical Sciences, New Delhi, India; Departments of Neurosurgery All India Institute of Medical Sciences, New Delhi, India BACKGROUND: Pediatric meningiomas (pMNG) are distinctly uncommon.Theirmolecular featuresarepoorlydefined.Hence, this studywasundertaken to determine the genetic and molecular alterations occurring in pMNG. METHODS: Cases were analyzed for 1p36, 14q32 and 22q deletion by FISH and AKT1E17K and SMOW535L mutations by direct sequencing. Immunohistochemistry was done for MIB1, Merlin, progesterone receptor (PR), p53, GAB1 and Stathmin. RESULT: Of the 34 pMNG cases analyzed, the mean age was 12.3 years with male preponderance. Non skull base and skull base meningiomas comprised of equal proportion of the cases (44% vs45%). On histopathology, 84.5%, 14% and 3% were WHO grade I, grade II and grade III, respectively. MIB1-LI was slightly higher in high grade pMNG (5.17% Vs1.5%). The difference in frequency of combined 1p/14q deletion in low and high grade tumours was not significant (7%vs33%,p 1⁄4 0.07). 22q deletion was frequent in both low and high grade pMNGs(82%vs67%). A concordance rate of 76% was observed between 22q deletion and Merlin expression. PR immunoreactivity was higher in lower grade pMNG(64%vs33%). Majority(94%) of pMNGs were immunonegative for p53. Surprisingly, AKT1E17K and SMOW535L gene showed no mutation. However, majority of the cases (61.7%) showed co-expression GAB1 and Stathmin. CONCLUSION: Absence of AKT1E17K and SMOW535L mutations suggest a different molecular genetics profile of pMNGs as compared to their adult counterparts. Presence of 1p/14q co-deletion even in low grade pMNGs and possible activation of PI3/AKT and SHH pathways (presence of GAB and stathmin) suggests that pMNGs are inherently aggressive. However, absence of large series precludes any definite conclusion. Neuro-Oncology 18:iii18–iii23, 2016. doi:10.1093/neuonc/now068.23 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Axis I psychiatric symptoms associated with HIV infection and personality disorder
Authors: J G Johnson, J B Williams, J G Rabkin, R R Goetz, R H Remien
Journal: American Journal of Psychiatry (1995)

The prevalences of personality disorders among HIV-positive and HIV-negative homosexual men were compared, and the presence of personality disorders was related to axis I psychiatric disorders, psychiatric distress, and impaired functioning.The subjects were 162 homosexual men who either were HIV seronegative (N = 52) or were seropositive and had absent to moderate physical symptoms (N = 110). Lifetime and current histories of DSM-III-R axis I disorders, current diagnoses of DSM-III-R personality disorders, and levels of anxiety, depression, hopelessness, and adaptive functioning were assessed.In both the seropositive and seronegative groups, 19% of the study participants were diagnosed with personality disorders. The seropositive participants with personality disorders reported higher levels of psychiatric symptoms and poorer functioning than all participants without personality disorders, and they were over six times as likely as the seronegative participants without personality disorders to have current axis I disorders.These findings indicate that HIV infection and personality disorders may interactively increase the likelihood of clinically significant psychiatric symptoms.
Primary PCI with or without Thrombectomy.
Authors: Roberto Diletti, Nicolas M van Mieghem, Felix Zijlstra
Journal: New England Journal of Medicine (2015)

_To the Editor:_   
A typical feature of recent trials on thrombus aspiration is the binary approach, with either thrombectomy or standard percutaneous coronary intervention (PCI) considered to be applicable to every patient. In an ideal trial, PCI alone would be compared with thrombectomy performed at the discretion of an experienced operator. The success of thrombus aspiration (an interventional action) is largely dependent on the skill of the individual operator, and data on the effectiveness of the procedure (e.g., histologic analysis of retrieved material) should ideally be reported.
Histopathogenesis of Carcinoma Induced in the Glandular Stomach of C57BL Mice by the Intramural Injection of 20-Methylcholanthrene
Authors: Harold L. Stewart, Katharine C. Snell, William V. Hare
Journal: JNCI Journal of the National Cancer Institute (1958)

A single dose of 0.3 mg. of 20-methylcholanthrene in on aqueous Methocel suspension was injected intramurally into the submucosa of the glandular stomach of 109 (effective number 108) strain C57BL mice. The experiment lasted 175 days. During this time mice were killed at regular intervals to afford material for a study of the histopathogenesis of carcinoma of the glandular stomach. Twenty-four of 50 mice killed in the effective tumor period had malignant gastric tumor with a carcinomatous element. Adenocarcinoma of the glandular stomach was diagnosed in a mouse killed on the 42nd day post injection and in 21 other mice necropsied between the 56th and 175th day. In addition, there was 1 mixed adenocarcinoma and sarcoma, 1 mixed adenoacanthoma and sarcoma, and 1 sarcoma. The results of this experiment compared with those of a somewhat similar but longer term experiment revealed a larger number of carcinomas in the present experiment. A possible explanation is that gastric neoplasms may fail to progress or may even regress after loss of methylcholanthrene from the site of injection in the wall of the stomach. As in experimental carcinomas of the forestomach and the small intestine, the histopathogenesis of induced carcinoma of the glandular stomach is a complicated process, participated in by the glandular mucous membrane of the stomach, the stroma, blood vessels, and muscularis. The experimental carcinomas of the glandular stomach appear to develop from multicentric neoplastic foci and to originate from the deep mucosa in association with umbilicate lesions.
Clinical Infection in Obstetrics and Gynaecology
Authors: Allan B. MacLean
Journal: Annals of Internal Medicine (1991)

Infection in obstetrics and gynaecology an historical perspective infection and the antenatal patient viral infections during pregnancy human immunodeficiency viral infection in obstetrics and gynaecology chlamydia in pregnancy and the neonate listeriosis and pregnancy tuberculosis in pregnancy infection and pre-term labour intrapartum infections infection complicating caesarean section neonatal sepsis puerperal pyrexia anti-microbial therapy in obstetrics and gynaecology pelvic inflammatory disease genitourinary medicine and the obstetrician and gynaecologist pelvic tuberculosis infections of the vulva and vagina female infertility and infection male infertility and infection urinary tract infection and its role in urinary incontinence sepsis in gynaecological surgery antibiotics prophylaxis in obstetrics and gynaecology infection as an aetiological agent in carcinoma of the lower genital tract cancer and immunosupression - risk of infection in patients with gynaecological cancer infection into the twenty-first century.
Additional cases of postchemotherapy rheumatism.
Authors: D E Smith
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.8.1625 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8336200 Additional cases of postchemotherapy rheumatism. D E SmithxD E SmithSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.8.1625 PDF "Additional cases of postchemotherapy rheumatism.." Journal of Clinical Oncology, 11(8), pp. 1625–1626© 1993 by American Society of Clinical Oncology
EPN-33FEASIBILITY AND TOLERABILITY OF INTRAVENOUS AND INTRAVENTRICULAR TRASTUZUMAB IN HER2-POSITIVE RECURRENT METASTATIC EPENDYMOMA
Authors: Diana S. Osorio, Andrew M. Donson, Nabil Ahmed, Mohamed S. AbdelBaki, Christopher R. Pierson, Daniel R. Boue', Jerome A. Rusin, Michael Guiou, Jeffrey R. Leonard, Nicholas K. Foreman, Jonathan L. Finlay
Journal: Neuro-Oncology (2016)
Tranylcypromine versus imipramine in anergic bipolar depression
Authors: J M Himmelhoch, M E Thase, A G Mallinger, P Houck
Journal: American Journal of Psychiatry (1991)

This investigation compared the efficacy of the monoamine oxidase inhibitor (MAOI) tranylcypromine with that of the tricyclic imipramine in the treatment of anergic bipolar depressive illness.A controlled, double-blind comparison was used to study 56 outpatients who met operationalized criteria for anergic bipolar depression. Patients with bipolar I and II depression were equally distributed between comparison groups. Outcome was measured by the patient-rated Beck Depression Inventory and the clinician-rated Hamilton Rating Scale for Depression, Raskin Mania and Depression Scales, Clinical Global Impression Scale, and the Pittsburgh Reversed Vegetative Symptom Scale. Twenty-eight patients were treated with tranylcypromine and 28 with imipramine. Seventy-three percent of bipolar depressive patients screened for the study met criteria for anergic depression, consistent with previous findings from studies in bipolar illness that stretch back over 100 years.Tranylcypromine produced statistically significant superior outcome in terms of lower attrition, greater symptomatic improvement, and higher global response without increased risk of treatment-emergent hypomania or mania.The authors propose that the apparently superior efficacy of tranylcypromine in bipolar depression is specifically linked to anergia and reversed neurovegetative symptoms. Bipolar I and bipolar II patients had comparable outcomes, but bipolar I patients had a significantly greater risk of treatment-emergent mood swings. Although the relatively poor showing of imipramine warrants close scrutiny, these findings provide further documentation of the utility of MAOIs in patients presenting with anergia, motor retardation, hyperphagia, and/or hypersomnia.