tbuckley/cabot-search huggingface dataset:
AB0686 Switched Memory B Cell Expansion is Associated with Disease Severity in Systemic Sclerosis
Authors: D. Simon, A. Bognár, P. Balogh, P. Németh, T. Minier, L. Czirják, T. Berki
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular injury, autoimmune phenomena, inflammation, and fibrosis of the skin and various internal organs. Several lines of evidence indicate that abnormal B-cell function plays a key role in the development of SSc. The anti-CD20 monoclonal antibody therapy seems to show some clinical efficacy in SSc further emphasizing the importance of B cells in the pathomechanism of the disease. The B-cell compartment in peripheral blood of SSc patients contains an elevated number of naive and a decreased number of memory B cells. <h3>Objectives</h3> The aim of the present research was to set up an algorithm for the extended analysis of these B-cell subsets and to evaluate the clinical significance of the defined subpopulations. <h3>Methods</h3> Peripheral blood samples were obtained from SSc patients and healthy controls, PBMCs were isolated using ficoll gradient centrifugation, followed by magnetic bead separation of CD19+ B cells. Multiparametric flow cytometry was performed with antibodies specific for CD27, IgD, CD80, CD95 molecules. Detection of CD27 and IgD was applied to distinguish between naive (CD27-IgD+) and memory (CD27+) B cells. IgD posivity was also used to separate non-switched (CD27+IgD+) and switched (CD27+IgD-) memory subsets. In addition to expression of CD80, which provides a co-stimulatory signal necessary for T cell activation and survival, expression of CD95 – FAS receptor was also examined to investigate the activation state of the previously identified B cell subpopulations. <h3>Results</h3> The ratio of naive B cells was higher, the proportion of memory B cells, including both subsets, was decreased in SSc patients compared to healthy controls. Among SSc patients the ratio of switched memory and CD95+ memory B cells was higher in diffuse cutaneous SSc and in patients with pulmonary fibrosis. The proportion of switched memory B cells was also elevated in the anti-Scl-70 antibody positive group compared to ACA positive patients. In dcSSc patients the ratio of CD95+ memory B cells was also higher. <h3>Conclusions</h3> According to our results detailed flow cytometric analysis of naive and memory B-cell subsets could contribute to better distinction between the two SSc subtypes and to the evaluation of disease severity, consequently may be a useful new tool in routine immunological diagnostics. <h3>Acknowledgements</h3> This work was supported by Hungarian Scientific Research Fund - OTKA 75912 and 112939. <h3>Disclosure of Interest</h3> None declared
Cryosurgery On Prostate Reported
Authors: W A Soanes
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New and improved titles.
Authors: G B Weiss
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.7.1829 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7602376 New and improved titles. G B WeissxG B WeissSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.7.1829 PDF "New and improved titles.." Journal of Clinical Oncology, 13(7), pp. 1829–1830© 1995 by American Society of Clinical Oncology
OP0181 Ultrasonography as Predictor for Flare in Rheumatoid Arthritis Patients with Low Disease Activity: Nine Month Results from Poet-Us-Study
Authors: F.B.G. Lamers-Karnebeek, T. Jansen, P. van Riel, J. Luime, J. Jacobs
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> A significant number of rheumatoid arthritis (RA) patients can reach low disease activity (LDA) by using TNF-inhibitors (TNF-i), but this therapy can cause serious side-effects and is expensive. Therefore it could be expedient to stop in case of LDA, especially if relapse can be predicted. Ultrasonography of joints seems to be a predictor in this respect in smaller studies. The Dutch POET (Potential Optimalisation of Expediency of TNF-i (TNF-inhibitor)) study, is a multicenter randomized prospective cohort study investigating if in patients with RA with LDA on TNF-i and conventional DMARD, the TNF-i can be stopped. Patients were randomized to continue or stop TNF-i. Part of this study is the POET-ultrasonography (US) study. <h3>Objectives</h3> To investigate whether US at the time of stopping TNF-i in RA patients with LDA can predict future flare. <h3>Methods</h3> Data of patients who stopped TNF-i in the POET study were used for this analysis. Participating patients had RA according to ACR 1987 criteria, &gt;6 months a DAS28 &lt;3.2 (LDA) and treatment with TNF-i &gt; one year next to a conventional DMARD, without dose change in the past six months. Nineteen trained ultrasonographers performed US at baseline of the study, using different US machines, of 20 joints (bilaterally: MCP 1-5 dorsal and volar, wrists and MTP 2-5 dorsal aspect). The joints were graded on grayscale (GS; 0-3) and power doppler (PD; 0-3). US signs of arthritis were defined as GS&gt;1 and/or PD&gt;0. Trial visits were performed every 3 months and when flare was suspected. Flare was defined as DAS28&gt;3.2 and at least &gt;0.6 increase compared to the DAS28 at inclusion. Cox regression was performed to compare TNF-i free LDA between patients with versus those without US signs of arthritis (figure). <h3>Results</h3> Nine months data were available for 248 patients. Twenty-one percent was lost to follow-up and censored at last observation. Higher age, longer disease duration, anti-CCP and IgM-RF positivity were all related to flare occurrence. Patients with US signs of arthritis in one or more joints had a greater risk of flare (HR 1.77; 95% CI of 1.16 to 2.70) and shorter relapse-free period compared to patients without US signs of arthritis (see figure). The table shows patient- and US-characteristics at inclusion for patients without flare within 9 months versus patients with flare. <h3>Conclusions</h3> On the group level, US can predict flare in RA patients with LDA in whom TNF-i is stopped. <h3>Disclosure of Interest</h3> F. Lamers-Karnebeek Grant/research support from: Abbvie, T. Jansen: None declared, P. van Riel: None declared, J. Luime: None declared, J. Jacobs: None declared
SAT0425 Pregnancy in Woman with Systemic Lupus Erythematosus
Authors: S. Monov, D. Monova, S. Basheva, R. Shumnalieva, A. Nikolov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disorder that primarily affects women of childbearing age. Pregnancy with SLE is associated with many complications. Therefore, the patient9s SLE disease activity needs to be managed as low as possible during pregnancy. <h3>Objectives</h3> The aim of this study is to examine the pregnancy outcomes in patients with systemic lupus erythematosus and the effect of SLE flare and treatment on pregnancy outcomes. <h3>Methods</h3> Data of 67 pregnancies of 59 SLE pdtients were analyzed retrospectively. Univariate analysis using chi-square test and logistic regression was used to assess the predictive value of each variable on binary outcomes. Lupus activity was based on SLE Pregnancy Disease Activity Index (SLEPDAI) criteria. <h3>Results</h3> During pregnancy, the disease activity was defined active in 62,69% of the pts. Termination of pregnancy was performed in 6 patients - indications were severe active lupus nephritis (5 cases) and dead fetus in utero (1 case). The relapse rate during pregnancy was 29,85%. In 22 cases disease activity was continued from the pre-pregnancy period. There were 5 elective, 4 spontaneous abortions, and 1 stillbirth, with 57 pregnancies resulting in live births including one multiple gestation. Preterm deliveries were significantly more frequent in patients with lupus nephritis, anti-Ro/SSA antibodies, hypertension, impaired renal function at the time of conception, preeclampsia/eclampsia, history of intravenous cyclophosphamide treatment and aPL than those without these features. Neonates with intrauterine growth retardation were more common in hypertensive, lupus nephritis and Raynaud9s-positive pregnancies. One fetal malformation (atrial septal defect) was recorded. Among 15 pregnancies with SLE that were in active stage at conception, 80% deteriorated during pregnancy. Of the 55 pregnancies that were stable at conception, 49,09% flared during pregnancy or postpartum. Preeclampsia/eclampsia, active lupus nephritis, impaired renal function were significantly associated with preterm birth; preeclampsia/eclampsia and thrombocytopenia were also significant predictors of maternal SLE flare-up. Prednisolone was found to improve the rate of live births, although it was also a predictor of prematurity. <h3>Conclusions</h3> Normal renal function, controlled blood pressure, the absence of lupus nephritis, aPL and anti-Ro/SSA antibodies are predictors of favorable fetal outcomes. The risk for flare may be a function of the disease activity prior to pregnancy. It is important to carefully plan pregnancy, and experienced rheumatologists and obstetricians should monitor SLE patients in pregnancy and postpartum. <h3>Disclosure of Interest</h3> None declared
New authority to oversee NHS complaints system must be independent, say MPs
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The body created to oversee and improve the NHS complaints system must be allowed real independence outside NHS control, MPs have said.

MPs on the parliamentary public administration and constitutional affairs committee published a report on 2 June,1 which said that the new Healthcare Safety Investigation Branch (HSIB), which began in April, would succeed only if the government legislated to guarantee its independence.

The new report is a follow-up to one published by the …
Salmonella - &amp;quot;old&amp;quot; organism, continued challenges !
Authors: S O’Brien, H de Valk
Journal: Eurosurveillance (2003)

Following the events of 11 September 2001, the ensuing spectre of bioterrorism and considerable efforts planning for the unthinkable (1), this Eurosurveillance issue reminds us of the continuing threat to public health from well-recognised pathogens, sometimes mistakenly judged to be controlled. Recently the incidence of salmonellosis has decreased substantially across the European Union, the number of cases reported to Enternet (2) declining from 100 267 in the peak year of 1997 to 73 006 in 2001 (I.S.T. Fisher - personal communication). However, recent events and the following articles illustrate continued challenges in salmonella control.
Dementia After Intracerebral Hemorrhage
Authors: Rebecca F. Gottesman
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Indirect vertical cultural transmission: a model for nongenetic parental influences on the liability to psychiatric illness
Authors: K S Kendler
Journal: American Journal of Psychiatry (1988)

A long tradition in psychiatry has focused on parental traits that directly influence the liability to psychiatric disorders in offspring. Because these traits rarely resemble the disorders they cause, traditional models of cultural transmission (which assume that "like perpetuates like") may not be appropriate. The author develops and illustrates several models for indirect vertical cultural transmission of psychiatric illness. These models generate falsifiable predictions about the pattern of risk in relatives of affected individuals. For example, all such models predict a substantially higher risk of illness in siblings than in offspring of affected individuals. It is now possible to develop and test rigorous models for the cultural transmission of psychiatric illness.
Soundings: The quest for transparency
Authors: Imre Loefler
Journal: BMJ (2005)

The concept of transparency as an ideal state is not limited to political and business morality. By making our bodies transparent, the first indications of structural failure and malfunction can be detected at molecular level and problems can be remedied.

The body can be made transparent by tests, analysis, and imaging. Clearly, knowledge of the finest details of one's macro- and micro-anatomy and physiology, including biochemistry at the subcellular level, are of great advantage, because continuous preventive maintenance allows repair and replacement. Eventually, when all systems are thoroughly understood, the body will become imperishable.

Soon everyone will wear a chain around the neck carrying a disc that will contain the complete body plan, including the entire DNA composition, the results of all biophysical and biochemical tests, and the current images of every part. Naturally this record will also contain a complete medical history, including details of medication, repairs, and replacements.

There is no doubt that such a development will be a great advantage. The problem lies in defining how often the disc will need to be updated. Obviously, annual updates of all the data will not serve the purpose, as some data will need to be updated at more frequent intervals, and several values will ideally require daily monitoring.

In a universally digitalised healthcare system one could do away with the traditional, imprecise, subjective approach. It would be unnecessary to ask any questions; even an inquiry as to the chief complaint would be redundant, as would be the inspection and the physical examination. The computer would produce an accurate diagnosis and would select the appropriate treatment without delay. Automated systems would dispense drugs and robots could eventually perform most surgery. The bothersome centerpiece of the outmoded medical system, the consultation, could be eliminated altogether.

The lynchpin of the perfect system of transparency will be legislation: adherence to the maintenance schedule and the wearing of the disc around the neck must be made compulsory.
Particulate matter exposures and adult-onset asthma and COPD in the Nurses' Health Study
Authors: Jared A. Fisher, Robin C. Puett, Jaime E. Hart, Carlos A. Camargo, Raphaёlle Varraso, Jeff D. Yanosky, Francine Laden
Journal: European Respiratory Journal (2016)

Exposure to ambient air pollution has been associated with acute respiratory effects, including acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD) [1, 2]. However, evidence on the association of long-term exposure to air pollution and incidence of asthma or COPD is limited, with most studies focused on asthma in children [3]. Among adults, recent reviews for both asthma [3] and COPD [4] discuss several studies that demonstrate either no increased risk or a suggestion of risk associated with traffic-related pollutants. With few exceptions [5–7], most have not used robust exposure assessments, large cohorts or fine-particulate exposures. Using previously validated spatiotemporal exposure models [8], we examined the association between long-term exposure to particulate matter (PM) air pollution and incident cases of adult-onset asthma and COPD from 1992 to 2000 in the US Nurses' Health Study (NHS). In the NHS cohort, lack of strong evidence for long-term PM association with adult-onset asthma and COPD <http://ow.ly/960A300pUSA> We thank the participants and staff of the Nurses' Health Study for their valuable contributions.
Radiotherapy error analysis older than yesterday.
Authors: C Weltens, W Van den Bogaert
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.6.2288 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9626238 Radiotherapy error analysis older than yesterday. C WeltensxC WeltensSearch for articles by this author , W Van den BogaertxW Van den BogaertSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.6.2288 PDF "Radiotherapy error analysis older than yesterday.." Journal of Clinical Oncology, 16(6), pp. 2288–2289© 1998 by American Society of Clinical Oncology
Treatment of Autoimmune Thrombocytopenic Purpura
Authors: R Centurioni, F Braianzoni, A Olivieri, S Rupoli, L DaLio, M Montillo, E D'Addezio, P Leoni
Journal: New England Journal of Medicine (1989)

One hundred and two patients with newly diagnosed autoimmune thrombocytopenic purpura (ATP) were treated with prednisone (1.5-2 mg/kg/day for 4 weeks). A favourable response, lasting more then 12 months, was obtained in 22,5% of the cases. Different therapeutic strategies, such as immunosuppressive drugs, high dose immunoglobulins, splenectomy and others, were applied in unresponsive or relapsed patients. In our case study, splenectomy has proved the most satisfactory (87% of positive results) thus representing, in our opinion, the only effective therapy for resistant or relapsed case.
REQUIREMENTS FOR ADMISSION TO MEDICAL SCHOOLS.
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Gastrointestinal Endoscopy
Authors: John F. Morrissey, Mark Reichelderfer
Journal: New England Journal of Medicine (1991)

FibersigmoidoscopyAlthough many indications for fibersigmoidoscopy are listed in Table 2, the majority of procedures are surveys for cancer in asymptomatic persons. Although the American Cancer Society123 and the National Cancer Institute124 endorse the performance of screening fibersigmoidoscopy for everyone over 40 at three-to-five-year intervals, not all authorities are convinced that the procedure is cost effective.125 , 126 All studies have found a substantial number of polyps and cancers, but no controlled trials have shown a decrease in mortality with the recommended screening.126 A recent survey of physicians by the American Cancer Society127 found that the proportion who routinely recommend survey examinations has . . .
Tuberculosis outbreak associated with a mosque: challenges of large scale contact tracing
Authors: S Duthie, C Black, G Douglas, A D Jackson, D Webster
Journal: Eurosurveillance (2008)

In this report, we describe the investigation and management of an outbreak of TB associated with a mosque in Scotland, and consider the implications of large-scale TB contact tracing. In 2005, an Algerian man living in the north-east of Scotland was found to be sputum smear-positive for TB. Initial investigation identified three (18.8%) close contacts with active disease. Due to the high rate of transmission, contact tracing was extended to casual contacts of the index case at a mosque. No sub-group at highest risk of exposure could be defined at the mosque. Screening of mosque attendees identified two cases (0.53%), with a further two identified by review of existing cases and enhanced surveillance. Two additional cases were linked to the outbreak by genetic profile. Response to the screening exercise was initially poor, but after modification of the communication strategy, 438 people were offered screening with 86% attending. The investigation and management of a TB outbreak is challenging and requires a complex message about risk to be communicated. In a mosque setting, there were additional complexities that, to the best of our knowledge, have not been reported previously. It was crucial, in designing the communication strategy, to identify key individuals within the community to assist with tailoring the message to address risk perception and to help to deliver the message. Despite this, approximately 50% of those considered to have the highest exposure (adult males regularly attending Friday lunchtime prayer meetings) did not come forward for screening. The screening of casual contacts in this setting was complex and time-consuming with a low detection rate.