tbuckley/cabot-search huggingface dataset:
FRI0599 Clinician Training in Motivational Communication Skills: The Impact of The Language of Change Program among Rheumatologists from across Canada
Authors: K. Lavoie, M. Bell, T. Taylor, R. Arendse, M. Saum, D. Faucher, M. Shawi, M. Camerlain
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Motivational communication (MC) is an evidenced-based communication style designed to enhance patients9 intrinsic motivation to engage in a healthy lifestyle and adhere to treatment. Due to its efficacy and popularity, the demand for physician training has risen markedly over the past decade. Despite the widespread dissemination of these programs, there is little empirical data on the extent to which they impact physician knowledge and attitudes. <h3>Objectives</h3> This study assessed the impact of a 1.5 hour introduction to MC workshop (phase I of Language of Change) on MC attitudes among rheumatologists. <h3>Methods</h3> This was a single group pre-post intervention trial. The MC training program, called <i>The Language of Change</i>, was developed by rheumatology and behavior change experts. The program being assessed consisted of 1 live workshop (a 1.5 hour introductory session) delivered by an MC expert alongside a dermatologist/nurse, to 53 rheumatologists from across Canada. Participants completed a battery of validated questionnaires measuring MC motivation, self-efficacy, outcome expectancies, and short term (30 day) intention to change, at baseline and after the session. T-tests were conducted to assess the effects of the introductory workshop on each questionnaire. <h3>Results</h3> Analyses revealed significant post introductory workshop effects on motivation to use MC (+.87, p&lt;.0001), MC self-efficacy (+1.37, p&lt;.001), outcome expectancies (including perceived program usefulness [+.73, p&lt;.002], pertinence [+.65, p&lt;.001], effectiveness [+.94, p&lt;.0001], potential to benefit physicians [+.72, p&lt;.0001] and potential to benefit patients {+.82, p&lt;.0001]), and short term (30 day) intention to change (pre=42%, post=66%). <h3>Conclusions</h3> This study indicates that a 1.5 hour introductory workshop on MC significantly increased motivation to use MC and MC self-efficacy, and had a uniformly positive impact on outcome expectancies and intention to use MC in practice. Results suggest that even low doses of MC training may impact healthcare professional attitudes and intention to change. <h3>Disclosure of Interest</h3> K. Lavoie: None declared, M. Bell: None declared, T. Taylor: None declared, R. Arendse: None declared, M. Saum Employee of: Janssen Canada Inc., D. Faucher: None declared, M. Shawi: None declared, M. Camerlain: None declared
International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels
Authors: Leonard K. Kaczmarek, Richard W. Aldrich, K. George Chandy, Stephan Grissmer, Aguan D. Wei, Heike Wulff
Journal: Pharmacological Reviews (2016)

A subset of potassium channels is regulated primarily by changes in the cytoplasmic concentration of ions, including calcium, sodium, chloride, and protons. The eight members of this subfamily were originally all designated as calcium-activated channels. More recent studies have clarified the gating mechanisms for these channels and have documented that not all members are sensitive to calcium. This article describes the molecular relationships between these channels and provides an introduction to their functional properties. It also introduces a new nomenclature that differentiates between calcium- and sodium-activated potassium channels.
Analysis of the Serum Free Light Chain Ratio and Its Prognostic Value in a Cohort of Patients with Chronic Lymphocytic Leukemia.
Authors: Chaim Shustik, Stephen Harding, Keyue Ding, Liting Zhu, Laura Z. Rassenti, Thomas J. Kipps, Lois Shepherd, Melanie Robson
Journal: Blood (2009)
Determinants of early-life lung function in African infants
Authors: Diane Gray, Lauren Willemse, Ane Visagie, Dorottya Czövek, Polite Nduru, Aneesa Vanker, Dan J Stein, Nastassja Koen, Peter D Sly, Zoltán Hantos, Graham L Hall, Heather J Zar
Journal: Thorax (2016)

<h3>Background</h3> Low lung function in early life is associated with later respiratory illness. There is limited data on lung function in African infants despite a high prevalence of respiratory disease. <h3>Aim</h3> To assess the determinants of early lung function in African infants. <h3>Method</h3> Infants enrolled in a South African birth cohort, the Drakenstein child health study, had lung function measured at 6–10 weeks of age. Measurements, made with the infant breathing via a facemask during natural sleep, included tidal breathing, sulfur hexafluoride multiple breath washout and the forced oscillation technique. Information on antenatal and early postnatal exposures was collected using questionnaires and urine cotinine. Household benzene exposure was measured antenatally. <h3>Results</h3> Successful tests were obtained in 645/675 (95%) infants, median (IQR) age of 51 (46–58) days. Infant size, age and male gender were associated with larger tidal volume. Infants whose mothers smoked had lower tidal volumes (−1.6 mL (95% CI −3.0 to −0.1), p=0.04) and higher lung clearance index (0.1 turnovers (95% CI 0.01 to 0.3), p=0.03) compared with infants unexposed to tobacco smoke. Infants exposed to alcohol in utero or household benzene had lower time to peak tidal expiratory flow over total expiratory time ratios, 10% (95% CI −15.4% to −3.7%), p=0.002) and 3.0% (95% CI −5.2% to −0.7%, p=0.01) lower respectively compared with unexposed infants. HIV-exposed infants had higher tidal volumes (1.7 mL (95% CI 0.06 to 3.3) p=0.04) compared with infants whose mothers were HIV negative. <h3>Conclusion</h3> We identified several factors including infant size, sex, maternal smoking, maternal alcohol, maternal HIV and household benzene associated with altered early lung function, many of which are factors amenable to public health interventions. Long-term study of lung function and respiratory disease in these children is a priority to develop strategies to strengthen child health.
Clofarabine Busulfan Conditioning Improves Outcomes in Patients with Active Acute Myelogenous Leukemia Undergoing Allogeneic Stem Cell Transplant
Authors: Alexis Zebrowski, Alexandra Hanlon, James Mangan, Jennifer Pinto-Martin, Selina M. Luger, Alison W. Loren, Elizabeth O Hexner, Ran Reshef, Saar I. Gill, Jacqueline Smith, Edward A. Stadtmauer, David Porter, Noelle V. Frey
Journal: Blood (2014)
Gain of the Centromeric Region of Chromosome 8, a New Germline Alteration In Juvenile Myelomonocytic Leukemia
Authors: Doris Steinemann, Tim Ripperger, Marcel Tauscher, Inka Praulich, Gudrun Göhring, Brigitte Pabst, Andrea Teigler-Schlegel, Brigitte Schlegelberger, Charlotte M Niemeyer, Christian Flotho
Journal: Blood (2010)
Cyclosporine A (CSA) Significantly Reduces the Cytotoxic Effects of In Vitro Expanded NK Cells: Implications for Adoptive NK Cell Therapy in the Setting of Allogeneic Hematopoietic Stem Cell Transplantation (HCT).
Authors: Hisayuki Yokoyama, Maria Berg, Andreas Lundqvist, J. Philip McCoy, Shivani Srivastava, Aleah Smith, Richard Childs
Journal: Blood (2007)
Shape Memory Silk Protein Sponges for Minimally Invasive Tissue Regeneration
Authors: Joseph E. Brown, Jodie E. Moreau, Alison M. Berman, Heather J. McSherry, Jeannine M. Coburn, Daniel F. Schmidt, David L. Kaplan
Journal: Advanced Healthcare Materials (2016)

Porous silk protein scaffolds are designed to display shape memory characteristics and volumetric recovery following compression. Two strategies are utilized to realize shape recovery: addition of hygroscopic plasticizers like glycerol, and tyrosine modifications with hydrophilic sulfonic acid chemistries. Silk sponges are evaluated for recovery following 80% compressive strain, total porosity, pore size distribution, secondary structure development, in vivo volume retention, cell infiltration, and inflammatory responses. Glycerol‐modified sponges recover up to 98.3% of their original dimensions following compression, while sulfonic acid/glycerol modified sponges swell in water up to 71 times their compressed volume, well in excess of their original size. Longer silk extraction times (lower silk molecular weights) and higher glycerol concentrations yielded greater flexibility and shape fidelity, with no loss in modulus following compression. Sponges are over 95% porous, with secondary structure analysis indicating glycerol‐induced β‐sheet physical crosslinking. Tyrosine modifications with sulfonic acid interfere with β‐sheet formation. Glycerol‐modified sponges exhibit improved rates of cellular infiltration at subcutaneous implant sites with minimal immune response in mice. They also degrade more rapidly than unmodified sponges, a result posited to be cell‐mediated. Overall, this work suggests that silk sponges may be useful for minimally invasive deployment in soft tissue augmentation procedures.
THU0102 Platelet Associated IGG in Patients with Rheumatoid Arthritis
Authors: M. Nishikawa, S. Kaneshiro, H. Owaki, T. Fuji
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Thrombocytopenia was sometimes shown in clinical medical treatment in patients with rheumatoid arthritis (RA). The causes of thrombocytopenia in patients with RA are various. Drug induced thrombocytopenia and idiopathic thrombocytopenia are ones of these causes. The diagnosis of thrombocytopenia is important because the method of treatment depends on it. <h3>Objectives</h3> Increased levels of platelet associated IgG (PAIgG) found in patients with idiopathic thrombocytopenia. We investigated in the relationship between platelet and PAIgG to evaluate the clinical significance in patients with RA. <h3>Methods</h3> Total 266 patients (60 males: 206 females) with RA were enrolled in this study. The serum level of PAIgG were examined. We evaluated age at onset of RA, age of PAIgG test, disease duration of RA, platelet number, platelet bindable IgG (PBIgG), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), rheumatoid factor (RF), anti-cyclic citrullinated peptide antibody (ACPA), matrix metalloproteinase-3 (MMP-3), Disease activity score including a 28-joint count (DAS28)-CRP, DAS28-ESR, simplified disease activity index (SDAI), clinical disease activity index (CDAI), and methotrexate (MTX) dose between PAIgG(+) and (−) groups. <h3>Results</h3> PAIgG were positive in 60.9% (162/266). There were no significant differences in age at onset of RA, age of PAIgG test, disease duration of RA, PBIgG, CRP, ESR, ACPA, MMP-3, DAS28-CRP, DAS28-ESR, SDAI, CDAI, and MTX dose between PAIgG(+) and (−) groups. There were significant differences only in RF and platelet number between PAIgG(+) and (−) groups. RF were higher in PAIgG(+) than those in (−) significantly (126.4 IU/mL vs. 84.4 IU/mL, p=0.03). RF(+) rate were also higher in PAIgG(+) than those in (−) significantly (75.3%: 122/162 vs. 61.5% 64/104, p=0.02). Platelet number were lower in PAIgG(+) than those in (−) significantly (207,000/μL vs. 218,000/μL, p=0.03). However, the PAIgG(+) patients whose platelet number were under normal limit were only 11.1% (18/162). There was no significant difference compared with PAIgG(−) patients whose platelet number were under normal limit (8.7%: 9/104). <h3>Conclusions</h3> PAIgG shows high value in immune thrombocytopenia, systemic lupus erythematosus, etc. However, we found high PAIgG(+) rate in RA which usually shows thrombocytosis. Although platelet number in PAIgG(+) were lower significantly, the mean value was within normal limit. The rates under normal limit between 2 groups were not different significantly. Although PAIgG had small effect on platelet number in RA, RF were higher in PAIgG(+) significantly. Further investigation is needed to evaluate the clinical significance of PAIgG in patients with RA. <h3>Disclosure of Interest</h3> None declared
Protein and glycomic plasma markers for early detection of adenoma and colon cancer
Authors: Jung-hyun Rho, Jon J Ladd, Christopher I Li, John D Potter, Yuzheng Zhang, David Shelley, David Shibata, Domenico Coppola, Hiroyuki Yamada, Hidenori Toyoda, Toshifumi Tada, Takashi Kumada, Dean E Brenner, Samir M Hanash, Paul D Lampe
Journal: Gut (2016)

Objective To discover and confirm blood-based colon cancer early-detection markers. Design We created a high-density antibody microarray to detect differences in protein levels in plasma from individuals diagnosed with colon cancer &lt;3 years after blood was drawn (ie, prediagnostic) and cancer-free, matched controls. Potential markers were tested on plasma samples from people diagnosed with adenoma or cancer, compared with controls. Components of an optimal 5-marker panel were tested via immunoblotting using a third sample set, Luminex assay in a large fourth sample set and immunohistochemistry (IHC) on tissue microarrays. Results In the prediagnostic samples, we found 78 significantly (t-test) increased proteins, 32 of which were confirmed in the diagnostic samples. From these 32, optimal 4-marker panels of BAG family molecular chaperone regulator 4 (BAG4), interleukin-6 receptor subunit beta (IL6ST), von Willebrand factor (VWF) and CD44 or epidermal growth factor receptor (EGFR) were established. Each panel member and the panels also showed increases in the diagnostic adenoma and cancer samples in independent third and fourth sample sets via immunoblot and Luminex, respectively. IHC results showed increased levels of BAG4, IL6ST and CD44 in adenoma and cancer tissues. Inclusion of EGFR and CD44 sialyl Lewis-A and Lewis-X content increased the panel performance. The protein/glycoprotein panel was statistically significantly higher in colon cancer samples, characterised by a range of area under the curves from 0.90 (95% CI 0.82 to 0.98) to 0.86 (95% CI 0.83 to 0.88), for the larger second and fourth sets, respectively. Conclusions A panel including BAG4, IL6ST, VWF, EGFR and CD44 protein/glycomics performed well for detection of early stages of colon cancer and should be further examined in larger studies.
The Risk of Secondary Myelodysplastic Syndrome/Acute Leukemia and Second Malignancy Following Yttrium-90 Ibritumomab Tiuxetan: 10-Year Single-Institution Experience of 138 Consecutive Patients
Authors: Anna Vanazzi, Chiara Grana, Daniele Laszlo, Marco Chinol, Mara Negri, Liliana Calabrese, Giovanni Paganelli, Giovanni Martinelli
Journal: Blood (2012)
Novel Tumor Suppressor Protein Programmed Cell Death 4 (PDCD4) Suppresses Activity of PI3K/Akt Pathway and Regulates Expression of p27 (Kip1) and c-myc, DAP5 and Willm’s Tumor (WT1) in Acute Myeloid Leukemia.
Authors: Bulent Ozpolat, Ugur Akar, Nancy H. Colburn, Gabriel Lopez-Berestein
Journal: Blood (2007)
Physiotherapy plan does not benefit simple ankle sprains, study finds
Authors: Ingrid Torjesen
Journal: BMJ (2016)

A programme of physiotherapy provides no more clinically important benefits for patients with simple ankle sprains than basic self management at home, a study published by The BMJ has shown.1

In a large randomised controlled trial to evaluate the benefits of physiotherapy for ankle sprains, researchers randomly assigned 503 patients aged 16-79, presenting from 2009 to 2013 with mild or moderate ankle sprain injuries at two hospitals in Kingston, Canada, to a control group receiving usual care or to …
BCL2L11 (BIM) Deletion Polymorphism Is Associated with Molecular Relapse after ABL Tyrosine Kinase Inhibitor Discontinuation in Patients with Chronic Myeloid Leukemia with Complete Molecular Response
Authors: Seiichiro Katagiri, Tetsuzo Tauchi, Yuu Saito, Tamiko Sugro, Michiyo Asano, Seiichiro Yoshizawa, Juri Sakuta, Daigo Akahane, Yuko Tanaka, Nahoko Furuya, Keiko Ando, Hiroaki Fujimoto, Seiichi Okabe, Moritaka Gotoh, Yoshikazu Ito, Tomohiro Umezu, Junko H Ohyashiki, Kazuma Ohyashiki
Journal: Blood (2014)
FRI0138 S100A12 and Calprotectin in Serum and The Aorta of Patients with Cardiovascular Disease and Inflammatory Rheumatic Disease: A Biopsy Study: Table 1.
Authors: K.M.C. Tjørve, M. Fagerhol, M. Wang-Fagerland, K. Mikkelsen, S.M. Almdahl, I. Hollan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Increased serum calprotectin (s-calprotectin) and S100A12 (s-S100A12) levels are associated with inflammatory rheumatic disease (IRD), and might be involved in the pathogenesis of cardiovascular disease (CVD). <h3>Objectives</h3> To compare s-calprotectin and s-S100A12 levels in CVD patients with and without IRD, to IRD patients without CVD, and to healthy controls (HC). Furthermore, to search for relationships between s-calprotectin levels and calprotectin expression in the aortic adventitia. <h3>Methods</h3> We examined s-calprotectin and s-S100A12 in patients from the Feiring Heart Biopsy Study: 69 IRD (CVD-IRD group) and 53 non-IRD (CVD group) patients undergoing coronary artery bypass grafting (CABG), 32 IRD patients without any clinical or laboratory sign of CVD (IRD group) and 30 HC. Using immunohistochemistry, we scrutinized biopsies taken during CABG from the aortic adventitia in 19 CVD-IRD and 20 CVD patients for the presence and extent of inflammatory cell infiltrates (ICIs) and calprotectin expression. <h3>Results</h3> We found no significant differences in levels of s-S100A12 between the four groups (p=0.56). There was not a significant difference in the calprotectin levels between the CVD-IRD and the IRD (1.30 vs 1.73 mg/l; p=0.16) groups. The groups with CVD (CVD and CVD-IRD) had significantly higher s-calprotectin level than the HC group (1.47 vs. 0.30 mg/l; p&lt;0.0001), and a statistically non-significant trend towards a higher s-S100A12 level (44.12 vs 25.36 mg/l; p=0.13). The groups with IRD (IRD and CVD-IRD) had a significantly higher s-calprotectin level than the CVD (without IRD) group (1.42 vs. 0.25 mg/l; p&lt;0.0001) and the HC group (1.42 vs. 0.29 mg/l; p&lt;0.0001). CVD was not independently related to s-calprotectin (p=0.36) neither in the total population nor in the RA subgroup. Calprotectin expression in the aortic adventitia was significantly related to the presence of inflammatory cell infiltrates (ICI; p=0.05), but not to s-calprotectin levels (p=0.95). <h3>Conclusions</h3> s-Calprotectin is independently related to IRD, but not to CVD (neither in the general population nor in RA). Thus, in theory, the previously observed association between s-calprotectin and CVD might be caused by the underlying inflammatory process, e.g. IRD, not by a causal role of calprotectin in the CVD pathogenesis. <h3>Disclosure of Interest</h3> None declared
Voreloxin (formerly known as SNS-595) in Combination with Cytarabine Demonstrates Preliminary Clinical Responses in a Phase 1 Study in Relapsed/Refractory Acute Myeloid Leukemia.
Authors: Jeffrey Lancet, Judith E. Karp, Larry D. Cripe, Gail J. Roboz, Matt Suster, Nguyen Tan, Rachael Hawtin, Judith Fox, Craig Berman, Glenn Michelson
Journal: Blood (2008)
Platelet Sensing of Microenviornmental Geometry Guides Adhesion and Spreading: A Quantitative Study At the Single-Cell Level
Authors: Ashley Kita, Yumiko Sakurai, David R Myers, Ross Rounsevell, Tae Joon Seok, Kyoungsik Yu, James Huang, Ming Wu, Daniel Fletcher, Wilbur Lam
Journal: Blood (2011)
Ph-Negative Hematopoiesis Emerging After Successful Treatment of Chronic Myeloid Leukemia Displays Severe and Persistent Telomeric Loss Which Is Particularly Prominent in Patients with Acquired Cytogenetic Abnormalities.
Authors: Chiara Lobetti Bodoni, Dario Ferrero, Elisa Genuardi, Daniela Sia, Mariella Genuardi, Valentina Giai, Alberto Rocci, Luigia Monitillo, Daniela Drandi, Simone Ferrero, Gianluca Isaia, Elisa Bernocco, Michela Boi, Monia Lunghi, Elisabetta Abruzzese, Massimo Pini, Franca Radaelli, Patrizia Pregno, Roberto Passera, Gianluca Gaidano, Mario Boccadoro, Carmelo Carlo-Stella, Marco Ladetto
Journal: Blood (2009)
IL-7 and Thymic Stromal Lymphopoietin (TSLP) Stimulate Proliferation of All Cells and Reverse mTOR Inhibitor-Induced Growth Inhibition, Suggesting a Role for IL-7Rα Signaling in All.
Authors: Valerie I. Brown, David Teachey, Junjie Fang, Stephan A. Grupp
Journal: Blood (2004)
PCR Analysis of Bacteria and Fungi in Early Phase of Hematopoietic Stem Cell Transplantation
Authors: Atsushi Fujieda, Akiko Nakamura, Kohshi Ohishi, Fumihiko Monma, Masahiro Masuya, Kazunori Nakase, Yoshiko Matsushima, Hideo Wada, Tsutomu Nobori, Naoyuki Katayama
Journal: Blood (2011)
Extremely Higher Incidence of CMV-pp65 Antigenemia After Allogeneic Hematopoietic Stem Cell Transplantation in Adult T-Cell Leukemia/Lymphoma (ATL) Compared with Other Hematological Diseases
Authors: Nobuaki Nakano, Yoshifusa Takatsuka, Shogo Takeuchi, Masahito Tokunaga, Ayumu Kubota, Mayumi Tokunaga, Torahiko Makino, Atae Utsunomiya
Journal: Blood (2012)
The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography and CT (PET-CT) for the Diagnosis of Infections in Hemato-Oncological Patients with Persistent Neutropenia and Fever.
Authors: Anat Gafter-Gvili, Hanna Bernstine, Liat Vidal, Mical Paul, Ron Ram, Pia Raanani, Moshe Yeshurun, Ofer Shpilberg, David Groshar
Journal: Blood (2009)
HMGA1, a Factor Enriched in Hematopoietic Stem Cells, Embryonic Stem Cells, and Hematologic Malignancy, Enhances Cellular Reprogramming to a Pluripotent Stem-Like Cell.
Authors: Linda Resar, Sandeep N Shah, Candace Kerr, Leslie Cope, Elias Zambidis, Amy Belton, David L. Huso
Journal: Blood (2012)
Effective Prevention of Acute and Chronic Graft-Versus-Host Disease with Anti-Lymphocyte Globulin (ATG) without Increase of Relapse in HLA-Identical Sibling Peripheral Blood Stem Cell Transplantation.
Authors: Nicolaus Kröger, Tatjana Zabelina, Francis Ayuk, Haefaa Alchalby, Christine Wolschke, Thomas Stübig, Evgeny Klyuchnikov, Jürgen Berger, Axel R. Zander
Journal: Blood (2012)