tbuckley/cabot-search huggingface dataset:
Narrow-band imaging in the prediction of surveillance intervals after polypectomy in community practice
Authors: Silvia Paggi, Emanuele Rondonotti, Arnaldo Amato, Lorenzo Fuccio, Alida Andrealli, Giancarlo Spinzi, Franco Radaelli
Journal: Endoscopy (2015)

<b>Background and study aims:</b> It has been proposed that the use of narrow-band imaging (NBI) for real-time histological assessment to determine postpolypectomy surveillance intervals is a cost-effective approach to the management of diminutive polyps. However, significant discrepancies in NBI performance have been observed among endoscopists; hence, professional societies recommend training, monitoring, and auditing. The aim of the present study was to evaluate the performance of real-time optical diagnosis for diminutive polyps after the inclusion of this approach in an internal quality assurance program, in order to assess its applicability in clinical practice <b>Patients and methods:</b> Four endoscopists attended periodic training sessions on NBI assessment of polyp histology before and during the study. Performance was audited and periodic feedback was provided. The accuracy of high-confidence NBI evaluation for polyps ≤ 5 mm in predicting surveillance intervals according to the European and US guidelines, and the negative predictive value (NPV) for adenoma in the rectosigmoid were calculated and compared with recommended thresholds (90 % agreement and 90 % NPV, respectively). <b>Results:</b> Overall, 284 outpatients (mean age 61.3 ± 18.2 years; 63 % males) were enrolled. A total of 656 polyps were detected, 465 of which (70.9 %) were diminutive (70.5 % adenomas). Sensitivity, specificity, positive and negative predictive values, and accuracy of high-confidence NBI predictions for adenoma in diminutive lesions were 95.3 %, 83.5 %, 93.5 %, 87.6 %, and 91.9 %, respectively. High-confidence characterization of diminutive polyps predicted the correct surveillance interval in 95.8 % and 93.3 % of cases according to European and American guidelines, respectively. NPV for adenoma in the rectosigmoid was 91.3 % <b>Conclusions:</b> For community settings in which endoscopists are adequately trained and performance is periodically audited, real-time optical diagnosis for diminutive polyps is sufficiently accurate to avoid postpolypectomy histological examination of resected lesions, or to leave rectosigmoid hyperplastic polyps in place. <break/>Trial registered at ClinicalTrials.gov (NCT02196402).
THE NUCLEOLUS OF THE CELL NUCLEUS
Authors: J L SIRLIN
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HG-125CD57 DEFINES A NOVEL SUB-POPULATION OF GLIOBLASTOMA STEM CELLS THAT HAVE GREATER INVASIVE POTENTIAL THAN CD133+ TUMOR CELLS
Authors: Lin Qi, Yulun Huang, Mari Kogiso, Hua Mao, Holly Lindsay, Patricia Baxter, Jack Su, Laszlo Perlaky, Ching Lau, Murali Chintagumpala, Xiao-Nan Li
Journal: Neuro-Oncology (2016)
Thromboembolism in pregnancy.
Authors: D M Ramsay
Journal: BMJ (1979)

Eighteen patients were given carefully controlled intravenous heparin for thromboembolic disease of pregnancy. Thirteen were treated in later gestation and postparium, mainly following warfin therapy. One was treated in early pregnancy and 4 in the postpartum period. Heparin was delivered by constant infusion and dosage regulated by maintaining the thrombin time at 2 to/ times normal. Therapy was stopped for a few hours before and after delivery so that the thrombin time was normal or nearly normal at birth. Two minor episodes of thrombosis recurred in 1 patient while on warfarin, and significant postpartum bleeding occurred in one other. Substituting heparin for warfarin in late gestation was of value in preventing neonatal bleeding complications.
Laparoscopic Findings in Wilson's Disease without Cirrhosis
Authors: T. Sakai, K. Shiraki, T. Tada, H. Fuke, M. Tanabe, H. Inoue, K. Sugimoto, S. Ohmori, K. Takase, T. Nakano
Journal: Endoscopy (2001)

Figure 1A 25-year-old man was referred to our hospital because of liver dysfunction with abnormal copper metabolism. Laparoscopic findings revealed a mild yellowish liver with smooth surface. There were multiple dark-bluish round spots 1-2 mm in diameter on the surface of both lobes, indicating uneven distribution of copper deposition. The patient was diagnosed as having the early stage of Wilson’s disease.^_stand_item=F587-1
TB-27SUBGROUP-SPECIFIC OUTCOMES OF CHILDREN WITH MALIGNANT CHILDHOOD BRAIN TUMORS TREATED WITH AN IRRADIATION-SPARING PROTOCOL
Authors: Eveline Teresa Hidalgo, Sharon L. Gardner, Svetlana Kvint, Shiyang Wang, Cheddhi Thomas, Benjamin Liechty, Sophie Phillips, Jonathan Serrano, David T. W. Jones, Volker Hovestadt, Stefan M. Pfister, Jeffrey C. Allen, Jeffrey H. Wisoff, Matija Snuderl, Matthias A. Karajannis
Journal: Neuro-Oncology (2016)
Validation and Refinement Of The Disease Risk Index For Stratification Of Patients Undergoing Allogeneic Stem Cell Transplantation: A Study Of 13,131 Patients From The Center For International Blood &amp; Marrow Transplant Research
Authors: Philippe Armand, Haesook T. Kim, Brent R. Logan, Zhiwei Wang, Edwin P. Alyea, Matt Kalaycio, Richard T. Maziarz, Joseph H. Antin, Robert J Soiffer, Daniel J. Weisdorf, J. Douglas Rizzo, Mary M. Horowitz, Wael Saber
Journal: Blood (2013)
Does mammographic density modify the characteristics of the breast cancer?
Authors: Aye Min Soe, Yu Yu Thar, Sonal Bordia, Maxim Shulimovich, Shalom Buchbinder, Aung Myint Tun, Lisset Rodriguez, Elizabeth Guevara
Journal: Journal of Clinical Oncology (2016)

e12057 Background: Increased mammographic density (MD) has been shown to be an independent risk factor for breast cancer. Women with dense breast as determined by a diagnostic mammogram are at 1.8 to 6 times greater risk of developing breast cancer than those of the same age without increased breast density. We investigated whether there is any association between MD and estrogen receptor ( ER ) or progesterone receptor ( PR ) status of the invasive breast cancer and ductal carcinoma in situ (DCIS) and whether the association between MD and breast cancer is modified by body mass index (BMI), menopausal status and race. Methods: We identified 144 patients with invasive breast cancer and 70 patients with DCIS diagnosed between 2012-2014 in our community hospital. We conducted the imaging reviews to identify MD and chart reviews to obtain the tumor characteristics of those patients. Multivariate analysis was performed to assess the association of BMI, menopausal status, race and ER or PR status of the breast cancer and MD. Results: We observed a positive association between positive ER or PR status and high MD ( MD > 50% ) in both invasive breast cancer and DCIS ( odd ratio: OR 4.73, 95 % CI 1.1-20.31; p value: 0.04 ). Among the patients with invasive breast cancer, BMI is inversely associated with high MD (OR: 0.49; 95% CI : 0.32-0.7; p = 0.0003). There was a trend towards a positive association between premenopausal status and high MD in both invasive breast cancer and DCIS. The inverse association was observed between African American women and high MD. However, these associations were not statistically significant, ( OR 2.69 , 95% CI 1.55-6.84; p: 0.08 ) and (OR 0.42; 95 % CI 0.14-1.22, p value: 0.11) respectively. Conclusions: High MD may be associated with increased occurrence of ER or PR positive breast cancers. There is also a possible inverse correlation between MD and BMI among patients with invasive breast cancer. Further prospective studies are warranted to evaluate these possible associations.
Prevalence, risk factors, and sequelae of long-term chemotherapy-induced peripheral neuropathy (CIPN) among breast cancer survivors.
Authors: Ting Bao, Susan Q Li, Jun J. Mao
Journal: Journal of Clinical Oncology (2016)

e21661 Background: CIPN is a common toxicity associated with chemotherapy, but its prevalence and risk factors in long-term breast cancer survivors are rarely studied. We aimed to determine CIPN prevalence, risk factors, and association with falls among breast cancer survivors. Methods: We conducted cross-sectional analyses among postmenopausal women with a history of stage I–III hormone-receptor-positive breast cancer who received taxane-based chemotherapy at an academic medical center. Participants reported neuropathic symptoms of tingling/numbness in the hands and/or feet on a 0–10 numerical rating scale. Multivariate logistic regression analyses were conducted to evaluate risk factors associated with the presence of CIPN. We also evaluated the relationship between CIPN and patient-reported outcomes of anxiety and depression, as measured by the Hospital Anxiety and Depression Scale; insomnia, as measured by the 7-item Insomnia Severity Index; and patient-reported falls. Results: Among 296 participants, mean age was 62.0 years (SD, 9.0; range, 28.3–89.0), the majority was white (87.2%), and mean time since breast cancer diagnosis was 76.1 ± 36.8 months (range, 24–201). In 58.4% of participants who reported CIPN, 30.7% rated their symptoms as mild, and 27.7% rated CIPN as moderate to severe. Compared with women of normal weight, being obese was associated with a higher incidence of PN, with adjusted odds ratios of 1.99 (95% CI: 1.09–3.62). Patients with CIPN reported greater insomnia severity (P < .001), anxiety (P = .003), and depression (P = .011) than those without. In addition, severity of CIPN was associated with higher rates of falls, with incidences at 23%, 31%, and 41% in the no-CIPN, mild, and moderate-to-severe groups, respectively (P = .021). Conclusions: More than half of long-term breast cancer survivors reported peripheral neuropathic symptoms, and obesity is a significant risk factor. Those with CIPN also reported increased anxiety, depression, insomnia, and greater rates of falls. Interventions need to target CIPN and comorbid psychological symptoms, and incorporate fall prevention strategies for aging breast cancer survivors.
QOS-39PRELIMINARY RESULTS OF AN ITALIAN SURVEY ON REHABILITATION CARE OF CHILDREN AND ADOLESCENTS WITH CENTRAL NERVOUS SYSTEM TUMORS
Authors: Federica Ricci, Daniele Bertin, Pierpaolo Gaglini, Francesca Rossi, Emanuela Ceriani, Chiara Cuminetti, Fabianna Timelli, Daniele Panzeri, Lucia Rizzato, Michela Peranzoni, Natascia Bertoncelli, Domenico D'Erasmo, Deborah Raffa, Paola Ciullini, Elenia Giometti, Elena Maria De Feo, Flavio Feri, Marina Ghetti, Paola Vezzoli, Giovanna Pellegrini, Speranza Gidari, Massimo Capozzolo, Alessandra Favetto, Moana Donato, Alessandra Revel, Franca Fagioli
Journal: Neuro-Oncology (2016)
Liraglutide in Weight Management
Authors: David M Gardner, Andrea L Murphy
Journal: New England Journal of Medicine (2015)

To the Editor: The report by Pi-Sunyer et al. on the Satiety and Clinical Adiposity — Liraglutide Evidence in Nondiabetic and Diabetic Individuals (SCALE) study (July 2 issue)1 is an important addition to obesity literature. Since this study might encourage long-term use of liraglutide, a glucagonlike peptide-1 (GLP-1) analogue, in many obese patients, we think that safety issues should be the object of particular scrutiny.2 As recently as 2010, the Food and Drug Administration (FDA) required that liraglutide undergo additional studies in animals and that a cancer registry be established to monitor the incidence of medullary thyroid cancer over the next 15 years in patients receiving liraglutide.3 Although it is encouraging that there were no reported cases of medullary thyroid cancer or increases in levels of serum calcitonin, follow-up was limited to 56 weeks and the study was not powered to detect rarer side effects. Of further concern is the imbalance in the incidence of malignant and premalignant breast tumors (10 events in the liraglutide group vs. 3 in the placebo group). As the investigators suggest, this finding might reflect a diagnosis bias, since it occurred more frequently among women who lost more weight, but such a hypothesis constitutes speculation. Further data and considerable caution may be required to avoid previous experiences.4
HG-42POSITRON EMISSION TOMOGRAPHY (PET) USING [11C]METHIONINE (MET) IN THE MANAGEMENT OF CHILDREN AND ADOLESCENTS WITH HIGH GRADE GLIOMAS AND BRAIN STEM GLIOMAS
Authors: Liudmila Shats, Tatiana Skvortsova, Margarita Belogurova
Journal: Neuro-Oncology (2016)
Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity
Authors: Ruth Eichner, Michael Heider, Vanesa Fernández-Sáiz, Frauke van Bebber, Anne-Kathrin Garz, Simone Lemeer, Martina Rudelius, Bianca-Sabrina Targosz, Laura Jacobs, Anna-Maria Knorn, Jolanta Slawska, Uwe Platzbecker, Ulrich Germing, Christian Langer, Stefan Knop, Herrmann Einsele, Christian Peschel, Christian Haass, Ulrich Keller, Bettina Schmid, Katharina S Götze, Bernhard Kuster, Florian Bassermann
Journal: Nature Medicine (2016)
HG-01A NOVEL GENODERMATOSIS SYNDROME INDUCED BY SOMATIC BRAF V600E MOSAICISM, COMPRISING CONGENITAL ANAPLASTIC ASTROCYTOMA AND LINEAR SYRINGOCYSTADENOMA PAPILLIFERUM
Authors: Yuko Watanabe, Hidetaka Niizuma, Kousuke Shido, Tetsuya Niihori, Takeshi Rikiishi, Yukihiko Sonoda, Yoko Aoki, Setsuya Aiba, Yoji Sasahara, Shigeo Kure
Journal: Neuro-Oncology (2016)
Pandemic H1N1 influenza lessons from the southern hemisphere
Authors: M G Baker, H Kelly, N Wilson
Journal: Eurosurveillance (2009)

Preview this article: Pandemic H1N1 influenza lessons from the southern hemisphere, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/14/42/art19370-en-1.gif
Phase I study of recombinant interleukin-1 beta in patients undergoing autologous bone marrow transplant for acute myelogenous leukemia
Authors: J Nemunaitis, FR Appelbaum, K Lilleby, WC Buhles, C Rosenfeld, ZR Zeigler, RK Shadduck, JW Singer, W Meyer, CD Buckner
Journal: Blood (1994)
A Prospective, Randomised Study to Compare Goserelin Acetate (Zoladex®) versus Cyproterone Acetate (Cyprostat®) versus a Combination of the Two in the Treatment of Metastatic Prostatic Carcinoma
Authors: S C Thorpe, S Azmatullah, G J Fellows, J C Gingell, P J O'Boyle
Journal: European Urology (1996)
A Phase I Trial of TGR-1202, a Next Generation Once Daily PI3K-Delta Inhibitor in Combination with Obinutuzumab Plus Chlorambucil, in Patients with Chronic Lymphocytic Leukemia
Authors: Daruka Mahadevan, Emily K. Pauli, Kathy Cutter, Lee Ann Dietz, Peter Sportelli, Hari P. Miskin, Marshall T. Schreeder
Journal: Blood (2015)
Multidrug Resistance in Chinese Hamster Cells: Effect of Liposome-Encapsulated Doxorubicin
Authors: Alain R. Thierry, Timothy J. Jorgensen, Diana Forst, James A. Belli, Anatoly Dritschilo, Aquilur Rahman
Journal: Cancer Communications (1989)

A Chinese hamster cell line (LZ), selected for multidrug resistance (MDR), exhibits a 3,000-fold resistance to doxorubicin, compared to parental V-79 cells. These drug resistant cells have amplified MDR genes, overexpress P-glycoprotein, and in the presence of doxorubicin show reduced intracellular drug accumulation. Using liposome-encapsulated doxorubicin (Rahman et al. Cancer Res. 45:796-803; 1985), we observed partial reversal of the resistance of LZ cells to this drug and a higher intracellular drug accumulation, compared to free drug. Parental V-79 cells, however, did not exhibit differences in survival or in drug accumulation when treated with encapsulated or free doxorubicin. Comparison of the effect of liposome-encapsulated doxorubicin with that of verapamil in reversing drug resistance showed that the liposomal preparation was as effective as verapamil used at its maximum clinically relevant concentration (1.5 microM). These results suggest that the use of liposomes as carriers of anticancer drugs may offer a strategy for overcoming MDR in tumor cells.
Re-emergence of dengue in Réunion, France, January to April 2012
Authors: S Larrieu, J S Dehecq, E Balleydier, M C Jaffar, A Michault, P Vilain, I Leparc-Goffart, D Polycarpe, L Filleul
Journal: Eurosurveillance (2012)

Since January 2012, 20 autochthonous cases of dengue virus (DENV) infection have been identified in Réunion. The first cases were detected on the western coast, but the two co-circulating viruses (DENV-1 and DENV-3) seemed to have spread later to different cities of the island. There is a non-negligible risk of increase in viral transmission over the following weeks, so health professionals and public health authorities in Réunion are preparing to face a potential epidemic.
QOS-12THE ASSOCIATION OF SOCIODEMOGRAPHIC AND MEDICAL FACTORS WITH CLINICAL OUTCOMES ASSESSMENTS (COAS) IN CHILDREN WITH EPENDYMOMA: RESULTS OF THE PEDIATRIC EPENDYMOMA OUTCOMES (PEO) PROJECT
Authors: Eugene Hwang, Kristina Hardy, Terri Armstrong, Alvina Acquaye, Anthony Gioia, Mark Gilbert, Tito Mendoza
Journal: Neuro-Oncology (2016)

QOS-12. THE ASSOCIATION OF SOCIODEMOGRAPHIC AND MEDICAL FACTORS WITH CLINICAL OUTCOMES ASSESSMENTS (COAS) IN CHILDREN WITH EPENDYMOMA: RESULTS OF THE PEDIATRIC EPENDYMOMA OUTCOMES (PEO) PROJECT Eugene Hwang1, Kristina Hardy1, Terri Armstrong3, Alvina Acquaye3, Anthony Gioia1, Mark Gilbert2, and Tito Mendoza3; Children’s National Medical Center, Washington, DC, USA; National Institute of Heatlh, Neuro-oncology Branch, Bethesda, MD, USA; UT Health Science Center at Houston, Houston, TX, USA BACKGROUND: Children with ependymoma frequently have recurring cycles of progression/treatment with resultant morbidity. Therefore, identifying sociodemographic and medical contributors associatedwith worse clinical outcomes is important for improved management. METHODS: Parents of children with ependymoma completed a national (U.S.) online survey that included parent-proxy PROMIS battery measures, educational status, household income, and child medical/treatment information. Analysis utilized an effect size measure (Hedge’s g) to estimate the association between COAs and studied variables. RESULTS: Twenty-seven families participated. Patients were 59% male, 85% non-Hispanic white with a median of 11 (range,5-22 years). Households included 30% without a college degree and 48% with less than $80,000 annual income. Over half of children had received chemotherapy (56%), multiple resections (56%), and experienced recurrence (52%). Lower household education status correlated with worse upper extremity functioning (g 1⁄4 0.67), fatigue (g 1⁄4 -0.64), and physical mobility (g 1⁄4 0.57)); conversely, an advanced educational background predicted poorerpsychological outcomes (anxiety g 1⁄4 0.43, anger g 1⁄4 0.56, andpeer relationships g 1⁄4 -0.64). Lower income was associated with more depression (g 1⁄4 -0.79) and anger (g 1⁄4 -0.59). Chemotherapy was associated with lower mobility (g 1⁄4 -0.42) and UE function (g 1⁄4 -0.77), but did not impact psychosocial outcomes. Multiple resections were associated with higher depression (d 1⁄4 0.56), but not with physical functioning/fatigue. CONCLUSION: Household educational status and income impact social, psychological and physical dysfunction reports in children with ependymoma. Unexpectedly, chemotherapy treatment was associated with worse physical functioning, whereas multiple surgical resections correlated with depression. These findings highlight the potential importance of COAs in augmenting more traditional assessments of treatment effect such as response and survival. Neuro-Oncology 18:iii145–iii158, 2016. doi:10.1093/neuonc/now081.12 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Petaloid Cataract
Authors: Jagat Ram, Rohit Gupta
Journal: New England Journal of Medicine (2016)

A 30-year-old man presented with deteriorating vision in the left eye. Three months earlier, he had sustained a concussion and trauma to the left eye in a collision that occurred while he was riding a bicycle without a helmet. Slit-lamp examination revealed white opacities in the form of decagonal “petals.”
Withdrawing Versus Withholding Freedoms: Nudging and the Case of Tobacco Control
Authors: Andreas T Schmidt
Journal: The American Journal of Bioethics (2016)

Is it a stronger interference with people's freedom to withdraw options they currently have than to withhold similar options they do not have? Drawing on recent theorizing about sociopolitical freedom, this article identifies considerations that often make this the case for public policy. However, when applied to tobacco control, these considerations are shown to give us at best only very weak freedom-based reason to prioritize the status quo. This supports a popular argument for so-called "endgame" tobacco control measures: If we believe that cigarettes would and should be withheld from entering markets in hypothetical scenarios in which they do not yet exist, then we also have reason to seek their abolition in situations, such as ours, in which cigarettes do exist—if necessary by banning their sale. The same considerations are then used to disarm objections that have recently been raised to using nudges in public policy.
Reductionist biology and population medicine--strange bedfellows or a marriage made in heaven?
Authors: R. J. Bulger
Journal: JAMA (1990)

An important contribution, in the form of a House of Delegates—approved policy report from the American Medical Association Council on Scientific Affairs, appears elsewhere in this issue ofThe Journal. Entitled The IOM Report and Public Health, 1 the Council report does three things very well: (1) it clearly and precisely summarizes one of the best and potentially most effective and influential Institute of Medicine reports of recent years; (2) it delineates the little-known, inadequately appreciated but extensive history of the relationships and interactions among the public health establishment, the community of practicing physicians, and the American Medical Association over the years; and (3) it presents a series of recommendations for physicians and organized medicine to follow vis-a-vis the public's health and society's efforts to optimize the health of its citizenry.  After describing the broad array of disciplines and professionals that must be brought to bear on the complex health