tbuckley/cabot-search huggingface dataset:
Abstract A37: Yes-associated protein 1 (YAP) in the growth and tumorigenesis of ovarian granulosa cells.
Authors: Xiangmin Lv, Chunbo He, Guohua Hua, Jixin Dong, John S. Davis, Cheng Wang
Journal: Clinical Cancer Research (2016)

Abstract Ovarian granulosa cells are essential for successful follicle development. Dysregulation of granulosa cell proliferation and differentiation may lead to impairment of female fertility or development of ovarian tumors. Although studies indicate that the Hippo signaling pathway plays critical roles in both development and tumorigenesis of several organs, its role in ovarian physiology and pathology remains largely unknown. The present study aims to investigate the role of YAP in ovarian granulosa cell proliferation, differentiation and transformation. Immunohistochemical analyses showed that the active form of YAP (nuclear YAP) was highly expressed in proliferative granulosa cells, whereas the inactive form of YAP (cytoplasmic YAP) was detected mainly in terminally-differentiated luteal cells, indicating that YAP may be involved in proliferation and differentiation of ovarian granulosa cells. Knockdown of YAP or pharmacological inhibition of YAP activity in human granulosa cells suppressed cell growth and reduced cell survival in both traditional 2D cell culture system and a novel 3D hanging-drop culture system, suggesting that YAP is essential for the growth and survival of human granulosa cells. In addition, ectopic expression of wild-type or constitutively active YAP impaired gonadotropin-induced differentiation of granulosa cells and stimulated the rapid growth and transformation of granulosa cells, findings which were reflected by increased colony formation in soft agar assay and growth of tumors in a xenograft mouse model. Injection of verteporfin (a selective antagonist of YAP) into female CD1 mice inhibited granulosa cell growth, induced GC apoptosis, and disrupted mouse ovarian follicle development, leading to severe subfertility. Consistently, mice with ovarian granulosa cell-specific expression of constitutively active YAP demonstrated disruption of granulosa cell differentiation and failure of ovarian follicle development. In conclusion, our studies demonstrate that homeostatic YAP expression and activation are essential for ovarian granulosa cell proliferation, differentiation and survival. YAP is a novel therapeutic target for treatment of ovarian diseases associated with granulosa cell dysregulation. Citation Format: Xiangmin Lv, Chunbo He, Guohua Hua, Jixin Dong, John S. Davis, Cheng Wang. Yes-associated protein 1 (YAP) in the growth and tumorigenesis of ovarian granulosa cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A37.
Cerebral malaria
Authors: AnthonyP Hall, Dominic Kwiatkowski, Malcolm Molyneux, Terrie Taylor, Nigel Klein, Nigel Curtis, Margot Smit, B.M Greenwood, CharlesM Poser, GustavoC Roman, F.J Kirkham, C.R.J.C Newton, P.A Winstanley, G Pasvol, N Peshu, D.A Warrell, K Marsh, HumphreyD.L Birley, DavidC.W Mabey, Mervyn Singer
Journal: The Lancet (1991)
Sex of Offspring after Use of Oral Contraceptives
Authors: D T Janerich, J M Piper
Journal: New England Journal of Medicine (1977)

A report by Dr. Rothman and Ms. Liess concluded that the sex ratio of offspring of women who had used oral contraceptives before pregnancy was not related to duration of use or the interval between termination of use and conception. However, there was a miscalculation of some subjects because not all gestations are 9 months in duration; there were more males in the shorter gestations and more females in the longer gestations. In New York State, for 1970-1975, the proportion of male births was 378,269 males to 357,333 females. This difference prompts cautious acceptance of their negative conclusion.
Abuses of the borderline diagnosis: a clinical problem with teaching opportunities
Authors: D E Reiser, H Levenson
Journal: American Journal of Psychiatry (1984)

The authors identify six ways in which the borderline diagnosis is commonly abused to express countertransference hate, mask imprecise thinking, excuse treatment failures, justify the therapist's acting out, defend against sexual clinical material, and avoid pharmacologic and medical treatment interventions. The paper focuses on diagnostic abuses that trainees present to clinical supervisors and educators. It attempts to show educators how to discern these abuses and turn them into teaching opportunities. These abuses are seen not only in trainees; they also occur in the professional community as a whole. Clinicians should expect the same diagnostic rigor of themselves that they expect of their students.
THE CARCINOID SPECTRUM
Authors: A SJOERDSMA, K L MELMON
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Racist Patient
Authors: Sachin H. Jain
Journal: Annals of Internal Medicine (2013)

Letters6 August 2013The Racist PatientSachin H. Jain, MD, MBASachin H. Jain, MD, MBAFrom Boston Veterans Affairs Medical Center, West Roxbury, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-159-3-201308060-00020 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:I want to clarify misconceptions that may have arisen as a result of my essay. I am in no way proud of how I reacted to Mr. R.'s incendiary comments. If I were faced with a similar situation in the future, I hope that I would react differently using one of the techniques or responses suggested. Angry or foul language has no place in sound clinical interactions between physicians and patients.I wrote the essay to raise the fact that, as clinicians, many of us are unprepared for degrading interactions with patients. They happen, and they hurt. We ... Author, Article, and Disclosure InformationAuthors: Sachin H. Jain, MD, MBAAffiliations: From Boston Veterans Affairs Medical Center, West Roxbury, Massachusetts.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Racist Patient Sachin H. Jain The Racist Patient Christine Laine and Michael A. LaCombe The Racist Patient Michael Nakao The Racist Patient Mitchel Galishoff The Racist Patient David A. Nardone The Racist Patient Sunil K. Sahai Metrics 6 August 2013Volume 159, Issue 3Page: 228KeywordsForecasting ePublished: 6 August 2013 Issue Published: 6 August 2013 Copyright & PermissionsCopyright © 2013 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
GPs achieve dramatic cut in antibiotic prescriptions
Authors: Jacqui Wise
Journal: BMJ (2016)

GPs in England have dramatically cut antibiotic prescribing, giving 2.6 million fewer prescriptions last year, figures from NHS Improvement have shown.

The total number of antibiotics prescribed by GPs fell by 7.3% in one year—down from 37 033 310 items in 2014-15 to 34 337 167 in 2015-16. This significantly exceeds the 1% reduction target that the national patient safety team set with Public Health England and NHS England.

GPs have also managed to reduce prescribing of broad spectrum …
Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Efficient Intratumoral Diffusion and Synthesized Anti-Glioma Therapy
Authors: Yayuan Liu, Ling Mei, Chaoqun Xu, Qianwen Yu, Kairong Shi, Li Zhang, Yang Wang, Qianyu Zhang, Huile Gao, Zhirong Zhang, Qin He
Journal: Theranostics (2015)

Cell penetrating peptides (CPPs) were widely used for drug delivery to tumor. However, the nonselective in vivo penetration greatly limited the application of CPPs-mediated drug delivery systems. And the treatment of malignant tumors is usually followed by poor prognosis and relapse due to the existence of extravascular core regions of tumor. Thus it is important to endue selective targeting and stronger intratumoral diffusion abilities to CPPs. In this study, an RGD reverse sequence dGR was conjugated to a CPP octa-arginine to form a CendR (R/KXXR/K) motif contained tandem peptide R8-dGR (RRRRRRRRdGR) which could bind to both integrin αvβ3 and neuropilin-1 receptors. The dual receptor recognizing peptide R8-dGR displayed increased cellular uptake and efficient penetration ability into glioma spheroids in vitro. The following in vivo studies indicated the active targeting and intratumoral diffusion capabilities of R8-dGR modified liposomes. When paclitaxel was loaded in the liposomes, PTX-R8-dGR-Lip induced the strongest anti-proliferation effect on both tumor cells and cancer stem cells, and inhibited the formation of vasculogenic mimicry channels in vitro. Finally, the R8-dGR liposomal drug delivery system prolonged the medium survival time of intracranial C6 bearing mice by 2.1-fold compared to the untreated group, and achieved an exhaustive anti-glioma therapy including anti-tumor cells, anti-vasculogenic mimicry and anti-brain cancer stem cells. To sum up, all the results demonstrated that R8-dGR was an ideal dual receptor recognizing CPP with selective glioma targeting and efficient intratumoral diffusion, which could be further used to equip drug delivery system for effective glioma therapy.
PTU-081 Endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: an observational study: Abstract PTU-081
Authors: L A Possamai, R Sabhrwal, A Dhar, K Monahan, P Vlavianos
Journal: Gut (2010)

<h3>Introduction</h3> Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) of pancreatic lesions is a valuable tool in the investigation of suspected pancreatic cancer. Recent international studies on the diagnostic utility of this technique have reported sensitivity and accuracy levels of &gt;90%. There is a paucity of UK centre data on diagnostic performance. In this retrospective observational study we aim to report the largest UK cohort and provide comparison with international standards. <h3>Methods</h3> Hammersmith Hospital is a regional pancreatobiliary referral centre. A single experienced endosonographer provides all diagnostic and therapeutic EUS services. A retrospective analysis of patients who underwent EUS-FNA for solid pancreatic lesions between Jan 2006 and Oct 2009 was performed. Cytopathology reports for cases were scrutinised. Cytological diagnosis was compared with the reference standard of surgical or biopsy histology, clinical and radiological evidence of disease progression, or in the case of benign cytology a minimum of 6 months clinical follow-up. <h3>Results</h3> A total of 113 EUS-FNAs for a solid pancreatic lesion were identified during the study period (average age 66 years, M/F ratio 1.1:1). The final outcomes were: pancreatic carcinoma (87/113, 77%), benign disease or pancreatitis (18/113, 16%) neuroendocrine tumour (5/113, 4%), metastasis (2/113, 1.7%), lymphoma (1/113, 0.8%). 15/113 cytology specimens were graded as “C4” or “highly suspicious of adenocarcinoma”, and in all the final diagnosis was pancreatic adenocarcinoma (PPV 100%). Performance characteristics were calculated both considering the C4/suspicious specimens as false negatives for malignancy and true positives (Abstract 081). Comparing the performance of EUS-guided FNA in years 2006–2007 to years 2008–2009 there was an improvement in sensitivity (78% to 92%) and accuracy (82% to 93%), respectively. <h3>Conclusion</h3> In solid pancreatic lesions FNA specimens classified cytologically as C4 have a 100% PPV for adenocarcinoma and should be considered diagnostic for this. The performance of EUS-FNA of solid pancreatic lesions in our institution, a UK regional referral centre, is comparable to international standards. A recent improvement in sensitivities and accuracy to in excess of 90% was noted. Further endosonographer experience, better case selection and routine use of “in-room” cytopathologist support may account for this and should be considered as strategies to improve accuracy further.
Book Review Glenn's Thoracic and Cardiovascular Surgery Fifth edition. Edited by Arthur E. Baue, with Alexander S. Geha, Graeme L. Hammond, Hillel Laks, and Keith S. Naunheim. 2002 pp. in two volumes, illustrated. Norwalk, Conn., Appleton and Lange, 1991. $102.
Authors: Lawrence H. Cohn
Journal: New England Journal of Medicine (1991)
Arteriosclerosis with Diabetes Mellitus
Authors: S F STRAIN
Journal: JAMA (1942)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Dermatitis herpetiformis
Authors: IODINE ELLIS FROM, KRISTIAN THOMSEN
Journal: British Journal of Dermatology (1974)

A 68-year-old man with a 2-month itching, symmetrical, polymorphous, bullous eruption showing histological and immuno-histological changes compatible with dermatitis herpetiformis is described. The eruption could be provoked by iodine and subsided on an iodine-free diet.
Counterpoint: The Case for Immediate Active Treatment
Authors: Stacy Loeb, William J. Catalona
Journal: Journal of the National Comprehensive Cancer Network (2007)

Active monitoring strategies recently have received attention as possible treatment options for men with low-risk prostate cancer who have a life expectancy of more than 10 years. However, no current criteria sufficiently predict outcomes for individuals with clinically localized disease and an otherwise long life expectancy who undergo either immediate or delayed treatment, or no treatment. This article describes the available evidence regarding treatment outcomes in men with low-risk prostate cancer and presents the case for immediate active treatment.
Resistance to the use of video in individual psychotherapy training
Authors: D A Goldberg
Journal: American Journal of Psychiatry (1983)

Given some of the unique advantages that videotechnology can afford psychotherapy educators, it is unfortunate that this medium is not more widely used for the training of residents in individual psychodynamic psychotherapy. The author examines some of the major forces that prevent greater acceptance of video by psychotherapy supervisors. Video is presented as a useful addition to more established teaching methods rather than as competitive with them.
Toward Value-Based Pricing to Boost Cancer Research and Innovation
Authors: Alberto Ocana, Eitan Amir, Ian F. Tannock
Journal: Cancer Research (2016)

The high market price of new anticancer agents has stimulated debate about the long-term sustainability of healthcare systems and whether these new agents can continue to be supported by public healthcare or by private insurers. In addition, some drugs have been approved with limited clinical benefit, raising concerns about setting a minimum requirement for medical benefit. Options to resolve these problems include raising the bar for approval of new drugs and/or pricing of new agents based on the medical benefit that they offer to patients. In this commentary, we suggest that new agents should be marketed in a two-step process that would include first the approval of the new drug by the regulatory agencies and second the introduction of a market price based on the medical benefit that the new intervention offers to patients. Introduction of value-based pricing would maintain the sustainability of health care systems and would improve drug development, as it would pressure pharmaceutical companies to become more innovative and avoid the development of compounds with limited benefit. Value-based pricing could also stimulate the funding of research directed to development of new anticancer drugs with novel mechanisms of action. Cancer Res; 76(11); 3127-9. ©2016 AACR.
Case 4-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, J. Michael Lazarus, Daniel R. Kuritzkes, Joseph V. Bonventre
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 39-year-old woman was admitted to the hospital because of peripheral cyanosis, hypotension, and acute renal failure.The patient had a 20-year history of Raynaud's phenomenon that occurred only on exposure to cold. She was well in other respects until four days earlier, when nausea developed, with vomiting of clear fluid. On the following day she began to have a mild nonproductive cough, sore throat, myalgia, chills, and sweats. In the early hours of the day of entry she awoke with painful cyanosis of the distal portions of both arms and legs, without exposure to cold. Cyanosis . . .
Abstract A04: Hyperactive mTOR induces neuroendocrine differentiation in LNCaP prostate cancer cell with concurrent upregulation of interferon regulatory factor 1
Authors: Mayuko Kanayama, Toshiya Hayano, Tatsuya Maeda, Shigeo Horie, Atsu Aiba
Journal: Cancer Research (2016)

Abstract The PI3K-Akt-mTOR pathway is frequently activated in prostate cancer. However, the precise function of mTOR in prostate cancer progression is yet to be elucidated. Thus, in this study, we performed a gain-of-function analysis by establishing human prostate cancer LNCaP stable line that expresses hyperactive mTOR (LNCaP-mTOR). Hyperactive mTOR induced neuroendocrine differentiation (NED) that can be suppressed by an mTOR inhibitor, rapamycin. Subsequent comprehensive mass spectrometric analysis in conjunction with cascade analysis indicates that the members of interferon regulator factor (IRF) family, especially IRF1, are key transcription factors in NED of LNCaP-mTOR. Aside from its major role in immune response, IRF1 is known to be a tumor suppressor. To further investigate the function of IRF1 in NED induced by hyperactive mTOR, we disrupted the IRF1 gene in LNCaP-mTOR by CRISPR/Cas system. The disruption of the IRF1 gene resulted in an acceleration of an NED-associated morphological change, elevation of neuroendocrine cell marker, neuron specific enolase, and a partial recovery of growth arrest. These results suggest that IRF1 partially suppresses NED at downstream of hyperactive mTOR. Together, our results indicate that two seemingly contradictory events, NED and the induction of IRF1, are induced by hyperactive mTOR, giving rise to a notion that pharmacological inhibition of mTOR can be a “double-edged sword” for prostate cancer treatments. Citation Format: Mayuko Kanayama, Toshiya Hayano, Tatsuya Maeda, Shigeo Horie, Atsu Aiba. Hyperactive mTOR induces neuroendocrine differentiation in LNCaP prostate cancer cell with concurrent upregulation of interferon regulatory factor 1. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr A04.
One-year follow-up study of posttraumatic stress disorder among survivors of Cambodian concentration camps
Authors: J K Boehnlein, J D Kinzie, R Ben, J Fleck
Journal: American Journal of Psychiatry (1985)

One year after receiving a diagnosis of posttraumatic stress disorder, five of 12 Cambodian concentration camp survivors who entered a treatment program no longer met the diagnostic criteria for the disorder, and symptoms in three others had improved. The intrusive symptoms of nightmares, sleep disorders, and startle reactions showed the most consistent improvement. Avoidance behavior, shame, and caring for others improved the least. The authors advocate use of tricyclic antidepressant medication and a consistent, supportive long-term psychotherapeutic commitment in treating this severely traumatized group.
Aminoflavone-loaded EGFR-targeted unimolecular micelle nanoparticles exhibit anti-cancer effects in triple negative breast cancer
Authors: Ashley M. Brinkman, Guojun Chen, Yidan Wang, Curtis J. Hedman, Nathan M. Sherer, Thomas C. Havighurst, Shaoqin Gong, Wei Xu
Journal: Biomaterials (2016)
Treatment of bulimia with nomifensine
Authors: H G Pope, P L Herridge, J I Hudson, R Fontaine, D Yurgelun-Todd
Journal: American Journal of Psychiatry (1986)

The authors treated 12 consecutive bulimic patients with nomifensine, a novel antidepressant recently approved for American use. Two patients developed fever, necessitating discontinuation of the drug. Of the other 10 patients, nine showed moderate or better improvement, with strikingly few side effects.
Golf: a matter of life and death, health and happiness, or just Olympic medals?
Authors: Roger Hawkes, Omar Malik, Andrew Murray
Journal: British Journal of Sports Medicine (2016)

2016 Sees the reintroduction of golf as an Olympic sport with 60 men and 60 women competing for gold. Although few of the 55 million people1 who play golf in over 200 countries on around 32 000 courses worldwide will ever hit these heights, they are subject to many of the relationships and effects that this sport has on longevity, physical health and mental health.

A major new project supported by the World Golf Foundation will assess some of the issues that may be associated with playing, for example, musculoskeletal injuries and skin cancers, and the public health benefits of golf for those playing at any level. In particular, cardiovascular, respiratory, metabolic, musculoskeletal, accident-related, mental health and wellness effects as well as more accurately characterising golf's role as a physical activity, and the effects of utilising golf buggies versus walking the course, are priorities for study.

Early information indicates that golf …