tbuckley/cabot-search huggingface dataset:
A New VISTA on combination therapy for negative checkpoint regulator blockade
Authors: Jie Deng, Isabelle Le Mercier, Anna Kuta, Randolph J. Noelle
Journal: Journal for ImmunoTherapy of Cancer (2016)

Negative checkpoint regulators function to restrain T cell responses to maintain tolerance and limit immunopathology. However, in the setting of malignancy, these pathways work in concert to promote immune-mediate escape leading to the development of a clinically overt cancer. In the recent years, clinical trials demonstrating the efficacy of blocking antibodies against these molecules have invigorated the field of immunotherapy. In this review, we discuss the current understanding on established NCR blockade and how strategic combination therapy with anti-VISTA antibody can be used to target multiple non-redundant NCR pathways.
Protein Intake and Breast Cancer Survival in the Nurses’ Health Study
Authors: Michelle D. Holmes, Jun Wang, Susan E. Hankinson, Rulla M. Tamimi, Wendy Y. Chen
Journal: Journal of Clinical Oncology (2017)

Purpose Greater protein intake has been associated with better breast cancer survival in several prospective studies, including among 1,982 women in the Nurses’ Health Study. We proposed to extend this previous finding. We hypothesized that protein, essential amino acid, branched-chain amino acid, and leucine intakes are associated with improved survival and that these associations are stronger in tumors expressing insulin receptor (IR). Patients and Methods We included 6,348 women diagnosed with stage I to III breast cancer between 1976 and 2004. There were 1,046 distant recurrences. Relative risks (RRs) and 95% CIs were calculated according to quintiles of updated postdiagnostic diet using adjusted Cox proportional hazards models based on follow-up until 2010. Results There was an inverse association between energy-adjusted protein intake and recurrence. Multivariable RRs for increasing quintiles of intake compared with the lowest were 0.95 (95% CI, 0.79 to 1.15), 0.92 (95% CI, 0.76 to 1.11), 0.75 (95% CI, 0.61 to 0.91), and 0.84 (95% CI, 0.69 to 1.03; trend P = .02). For animal protein intake, the RRs were 0.88 (95% CI, 0.73 to 1.06), 0.85 (95% CI, 0.70 to 1.02), 0.75 (95% CI, 0.62 to 0.92), and 0.78 (95% CI, 0.63 to 0.95; trend P = .003). Neither essential amino acids, branched-chain amino acids, nor any individual amino acid stood out as being the source of the association. The association also did not differ by IR status. There was no clear association with any protein-containing foods. Conclusion We found a modest survival advantage with higher intake of protein, regardless of IR status. There was no clear mechanism for this association, although it is consistent with prior studies. Our data suggest that there is likely no advantage for women with a history of breast cancer in restricting protein intake or protein-containing foods.
AB1064 Evaluation of Safety Skills of Biotherapies in Tunisia
Authors: I. Henchiri, K. Ben Abdelghani, A. Fazaa, S. Kassab, A. Laatar, L. Zakraoui
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Biotherapies have become common practice in Tunisia, however, they present specific risks that patients must know and learn to manage. So far, patients9 security skills have not been studied in our country. <h3>Objectives</h3> The present work aims to assess the skills level of patients using biotherapies, in order to improve them. <h3>Methods</h3> Patients with chronic arthritis were recuited. we have established a questionnaire with practical situations in which the patient is confronted, based on the biosecure questionnaire. the main items were the leading symptoms to consult, vaccination, contraception, and situations excluding biotherapy. <h3>Results</h3> Thirty nine patients were recuited for the study, 77% with SA and 23% with RA. The mean age was 52, and 54% were female. 48% of patients have high education level. Etanercep was used in 15 cases, adalimumab in 12 cases, infleximab in 9 cases and one patient used tocilizumab. The mean duration of biotherapy was four years. 38% were in clinical remission. 69% had already received therapeutic education session about security of biotherapy use, by a doctor in 77% of cases. The median score of the questionnaire was 71,4% (58,8–100%). skills on symptoms must lead to consult and contraception are the least mastered. <h3>Conclusions</h3> This work showed that all patients didn9t master all situations concerning biotherpy. However, it is important for patients to have a basic control, to minimize the incidence of severe and avoidable side effects such as severe infections. <h3>Disclosure of Interest</h3> None declared
PTU-088 De Novo Cirrhosis in Old Age is Associated with Significant Delays in Diagnosis, High Incidence of Decompensation at Presentation and High Mortality
Authors: S Ghuman, M Czajkowski, J Hewitt, A Yeoman, A Gardezi
Journal: Gut (2016)

<h3>Introduction</h3> Mortality related to end-stage liver disease is increasing. Coupled with an ageing population, this will lead to increasing numbers of those aged over 65 with a de novo diagnosis of cirrhosis. However, the incidence and clinical behaviour of cirrhosis in old age is not well understood. Our aim was to evaluate and elucidate the characteristics of cirrhosis in elderly patients. <h3>Methods</h3> All patients aged over 65 with a diagnosis of cirrhosis at our institution were identified using the health board electronic record. Data on patient demographics, date and method of diagnosis, liver function tests (LFTs), MELD scores, presence of decompensation and outcomes (varices, renal impairment, hepatocellular carcinoma [HCC], death) were collected and analysed. <h3>Results</h3> 395 cirrhotics aged over 65 were identified. Clinical details were unavailable for 12, 7 had received a liver transplant and 81 were first diagnosed under 65 hence excluded from analysis. Median age was 74 (65–92) and 179/295 (60.7%) were male. The commonest aetiologies of cirrhosis were alcohol (86/295), cryptogenic (81/295) and NASH (62/295). Mode of diagnosis was a combination of laboratory and imaging features (USS, CT or MRI) in 86.8%, liver biopsy in 8.8% and fibroscan in 4.4%. Abnormal LFTs prior to diagnosis were found in 90.5%. Importantly, median delay in diagnosis of cirrhosis from first abnormal LFT was 72 months (1–168). Consequently, 54.6% were decompensated at first presentation. For the cohort, median MELD score was 9 (6–40) at diagnosis. In terms of complications, 139/295 (47.1%) developed ascites, 41/295 (13.9%) had atleast one episode of hepatic encephalopathy and 93/295 (31.5%) developed varices of whom, 24.7% bled. Renal impairment was common, occurring in 164/295 (55.6%). This comprised one or more episodes of acute kidney injury (AKI) in 113/164 (68.9%) and pre-existing CKD in the remainder. Importantly, HCC was diagnosed in 61/295 (20.7%); identified at diagnosis of cirrhosis in 72.1%. Active treatment for HCC occurred in 57.5%; the remainder palliated. Over half the cohort (58.8%) had died at the time of analysis, with median time from diagnosis of cirrhosis to death 13 months (0–116). In the compensated cirrhotics the median was 26 months versus only 9 months in those decompensated at presentation (p = 0.0027). <h3>Conclusion</h3> De novo cirrhosis in the elderly is associated with significant delays in diagnosis from time of first abnormal LFT, high incidence of decompensation, renal impairment and HCC. Consequently short term mortality is high. Abnormal LFTs should therefore not be ignored. Furthermore, in those with established cirrhosis, close attention should be paid to renal function and potential impact of concomitant diseases and polypharmacy on this. <h3>Disclosure of Interest</h3> None Declared
The cryptic IRF2BP2-RARA fusion transforms hematopoietic stem/progenitor cells and induces retinoid-sensitive acute promyelocytic leukemia
Authors: J V Jovanovic, M C Chillón, C Vincent-Fabert, R Dillon, E Voisset, N C Gutiérrez, R G Sanz, A A M Lopez, Y G Morgan, J Lok, E Solomon, E Duprez, M G Díaz, D Grimwade
Journal: Leukemia (2016)
SAT0539 A New Method for The Quantitative Analysis of Hand Muscle Volume for Patients with Rheumatoid Arthritis
Authors: A. Friedberger, O. Museyko, C. Figueiredo, T. Bäuerle, O. Chaudry, A. Grimm, G. Schett, K. Engelke
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is characterized by bone, cartilage and muscle loss in context of chronic inflammation. While bone and cartilage damage have been extensively studied in the past, the effects of RA on the muscles of the hand have not been studied. This situation is surprising, since visible hand muscle atrophy is a hallmark of RA and hand muscle composition determines the functional state of the patients function. <h3>Objectives</h3> Development of a method to quantitatively assess hand muscles in patients with RA, using magnetic resonance imaging (MRI) and 3D segmentation of the hand muscles. <h3>Methods</h3> T1 weighted MRI scans of healthy subjects and RA patients were used to develop a new segmentation method for hand muscles. Three groups (20 subjects each) were studied: (1) healthy subjects, (2) untreated RA patients and (3) DMARD-treated RA patients. The new approach uses a graph cuts based segmentation, which is initialized by fuzzy clustering. In a second step the segmented muscle volume of interest (VOI) is further refined and limited to the interosseal muscles and the <i>thenar</i> and <i>hypothenar</i> eminence. This segmentation procedure is fully automated. Nevertheless an extensive set of 3D editing tools such as hole filling, morphological operators and 3D surface manipulation is available to the operator, should the automatic approach not be satisfactory. Typically this happens in elderly diseased subjects with pathologic muscle and bone changes. The results of the automatic hand muscle segmentation were checked and confirmed by two experienced MRI readers. <h3>Results</h3> The automatic segmentation procedure took about 3 min per patient. In about 70% of the cases the automatic procedure resulted in an accurate muscle segmentation, as judged by the experts. In 30% of the cases additional operator interaction was necessary, primarily to correct for over segmentation. On average, the user interaction could be completed within 2 min. Final segmentation results were confirmed again by the experts. The figure shows a slice of a T1 weighted fat suppressed MRI image in the metacarpal region. Top without and bottom with overlaid muscle VOI (red). The quantitative analysis of muscle volume and the determination of among group differences is currently being performed. <h3>Conclusions</h3> We successfully developed a new accurate 3D-segmentation for hand muscles, which allows quantitative analysis of hand muscles in RA patients. <h3>Disclosure of Interest</h3> None declared
Safety and Clinical Activity of Temsirolimus in Combination with Rituximab and DHAP in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma - Results of the Part I Cohort of the STORM Trial
Authors: Mathias Witzens-Harig, Ulrich Keller, Andreas Viardot, Christian Buske, Anne Crombé, Elisabeth Hoenig, Julia Meissner, Anthony D Ho, Reinhard Marks, Martin H. Dreyling, Georg Hess
Journal: Blood (2015)
PWE-032 Fatty Liver Index (FLI), Which is An Accurate Predictor of Nonalcoholic Fatty Liver Disease (NAFLD), Is A Better Predictor of Cardiovascular Disease Risk in Type 2 Diabetic Patients than The UK Prospective Diabetes Study (UKPDS Risk Engine V 2.0)
Authors: D Caroli, A Nogara, E Rosa-Rizzotto, F De Lazzari, A Boscolo Bariga, R Valle
Journal: Gut (2016)

<h3>Introduction</h3> NAFLD, which is increasingly and rapidly becoming the cause of liver disease in Western countries, is characterised by higher serum triglyceride and LDL levels, lower HDL levels, insulin resistance, and glucose intolerance, all crucial risk factors for the development of atherogenesis. The UK Prospective Diabetes Study (UKPDS risk engine v 2.0) and the Fatty liver index (FLI) are both validated prognostic scores for cardiovascular disease (CVD) risk and NAFLD in diabetic patients. <h3>Methods</h3> We retrospectively analysed 1902 patients attending our Diabetes Ambulatory in 2012–2013. The UKPDS risk engine and the FLI were calculated for each of these patient. Ninety-nine (19.2%) of these patients resulted at high CVD risk according to their UKPDS evaluation and underwent a complete CVD assessment (ergometric/ecostress test (EET), coronarography (CORO)). A two tailed t-test, Person’s Chi square test, and analysis of variance (ANOVA) were carried out. <h3>Results</h3> Sixty-six (59 M, mean age 68.1 y, mean disease duration 16.1 y, HbA1c &gt; 7 prevalent) pts presented UKPDS positive/FLI &gt; 60, 8/66 CORO+ (5 percutaneous transluminal coronary angiopathy-PTA, 3 cardiac bypass sugery-CABG, 1 peripheral transluminal angioplasty-PTA AAII) and 5 (4 M, mean age 68.6 y, mean duration disease 18.4 y, HbA1c &gt; 7 prevalent) pts presented UKPDS positive/FLI &lt; 20,1/5 CORO+ (1 PTCA; 1 CABG; 0 PTA, AII). In the light of this analysis, were able to pinpoint a FLI cutoff that is better able to identify, with respect to UKPDS, patients who will result positive at CORO (FLI &gt; 52 detected 9/14 pts positive at CORO with p &lt; 0.05). Ninety-nine pts UKPDS positive(EET negative 69.6% &gt; 69/99) (100% &gt; 14/14 CORO+) vs 81 pts FLI &gt; 52 (EET negative 92.5% &gt; 75/81) (64.2% &gt; 9/14 CORO+). As expected, we found a significant association between CORO+ and FLI+ patients and microalbuminuria (p &lt; 0.048), cholesterol (p &lt; 0.020); triglycerides (p &lt; 0.001), and LDL (p &lt; 0.005). The only drug associated to CV risk was cardioaspirn (p &lt; 0.003). <h3>Conclusion</h3> Study results demonstrate that FLI can be used as a marker to predict CVD risk in patients with FLI &gt; 52. The number of patients who undergo CVD screening with a low percentage of positivity can thus be reduced. An early and aggressive treatment and monitoring program can instead be begun for type 2 diabetic patients with FLI &gt; 52 and a reasonable suspicion of NAFLD because this population has higher risk of developing CVD events with respect to patients with FLI &lt; 20. <h3>Disclosure of Interest</h3> None Declared
COPD diagnosis must improve, says report by Royal College of Physicians
Authors: Jacqui Wise
Journal: BMJ (2016)

Accurate diagnosis of chronic obstructive pulmonary disease (COPD) must improve to avoid expensive, unsafe, and ineffective treatments being prescribed to people who do not have the condition, a report from the Royal College of Physicians has found.1

The report, COPD in England—Finding the Measure of Success , also suggests that some of the most clinically useful and cost effective treatments for COPD, such as nicotine replacement therapy, targeted drug treatment, and pulmonary rehabilitation, are underused.

Some 1.2 million people in the United Kingdom have had COPD diagnosed, and 30 000 people die of the disease each year. Previous national …
The End of Obamacare
Authors: Jonathan Oberlander
Journal: New England Journal of Medicine (2016)

Interview with Dr. Jonathan Oberlander on what a Trump presidency could mean for the future of health care reform. (13:24)Download Health care reform in the United States is headed backward. It is uncertain which parts of the Affordable Care Act will survive past 2017 and what will follow it. What is certain is that Obamacare as we know it will end.
Protect UK childhood obesity plan from further weakening, urges health committee chair
Authors: Caroline White
Journal: BMJ (2016)

The UK government’s fledgling childhood obesity plan is still vulnerable to lobbying from vested interests, and certain elements risk “slipping off” the agenda, the chair of the parliamentary Health Select Committee has warned.

Sarah Wollaston’s comments come as new figures from the national child measurement programme show that the prevalence of obesity among primary schoolchildren in England has risen over the past year and that the gap between children in the least and most deprived parts of the country has widened further.1

The serially delayed plan, which the health secretary, Jeremy Hunt, had wanted to be a “game changing moment,”2 was heavily criticised by medical experts and campaigners when it was published in August, amid accusations that …
Abnormal Expression Of WT1-As, MEG3 and ANRIL Long Non-Coding RNAs In Primary Myelofibrosis and Their Clinical Correlates
Authors: Valentina Pennucci, Roberta Zini, Ruggiero Norfo, BiSci BiSci, Paola Guglielmelli, Elisa Bianchi, Simona Salati, Giorgia Sacchi, Zelia Prudente, Elena Tenedini, Samantha Ruberti, Chiara Paoli, Tiziana Fanelli, Carmela Mannarelli, Enrico Tagliafico, Sergio Ferrari, Alessandro M Vannucchi, Rossella Manfredini
Journal: Blood (2013)
Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts
Authors: Y. Terry Lee, Colleen Byrnes, Jaira F. de Vasconcellos, Megha Kaushal, Antoinette Rabel, Laxminath Tumburu, Joshua M. Allwardt, Jeffery L. Miller
Journal: Blood (2014)
Electroencephalograms During Hypercapnia
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In Early-Chronic Phase Chronic Myeloid Leukemia Patients Treated with Imatinib, Resistance Is Rarely Mediated by Abl Kinase Domain Mutations.
Authors: Simona Soverini, Alessandra Gnani, Sabrina Colarossi, Fausto Castagnetti, Elisabetta Abruzzese, Serena Merante, Massimo Breccia, Adele Capucci, Giorgina Specchia, Franca Radaelli, Francesca Palandri, Angela Poerio, Ilaria Iacobucci, Marilina Amabile, Gianantonio Rosti, Michele Baccarani, Giovanni Martinelli
Journal: Blood (2007)
THU0591 Clinical Features of Erythema Nodosum in Sarcoidosis
Authors: Y. Karpova, B. Belov, O. Egorova, S. Radenska-Lopovok
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Erythema nodosum (EN) is a type of septal panniculitis with multiple underlying etiological trigger factors. Combination of EN with involvement of ankle joints, fever and intra-thoracic lymphatic nodes (ITLN) is known as the Lőfgren syndrome. This syndrome is associated with acute clinical course of sarcoidosis, which usually does not require a morphological confirmation. <h3>Objectives</h3> To analyze specific clinical features of EN in sarcoidosis patients. <h3>Methods</h3> 125 EN patients (M-21,F-104), aged 18 - 69 years associated with sarcoidosis were examined. All patients were subjected to standard diagnostic clinical examination and lab procedures, including chest computed tomography (CT). <h3>Results</h3> Mean age of patients was 42±12 years. Disease duration up to 1 month was documented in 35% patients, 1- 3 months – in 41%, &gt;3 months – in 20%. Range of complaints included cough – in 24% patients, and fatigue – in 10%. Dyspnea, sweating, myalgia, and sore throat were found in 5% of patients each, respectively. Skin lesions typically occurred on the lower leg (96%), but also on the thighs (35%), the upper limbs (24%), and on the trunk (3%). Average number of nodules was 15±13. More than 10 nodules in number were documented in 64% of cases. Dense aggregation of nodules was found in 46% patients. The VAS score was 45±28 mm. Acute EN course was documented in 20% of cases, subacute - in 62%, and chronic – in 18% of patients. Distribution of joints involved looks as follows: ankles – 92%, shoulder – 11%, small joints in the hand and feet– 3%. CT findings included enlarged ITLN in 65% of cases, ground glass opacity (GGO) pulmonary lesions- in 35%. GGO pulmonary lesions predominated in male patients (30%), (<i>p</i>=0,004 R=0,25), demonstrating nodule-aggregation pattern in the majority of cases (<i>p</i>=0,0009 R=0,29). In patients with isolated ITLN involvement, cough (<i>p</i>=0,0048 R=0,25), and subacute course (<i>p</i>=0,016 R=0,22) were the special clinical features of the disease. <h3>Conclusions</h3> combination of ankle joints involvement, fever, and EN necessitates thoracic CT, as in 1/3 of such patients lungs would inevitably be involved. Male gender and EN aggregation pattern are most likely indicative of the emergence of GGO-symptom. <h3>Disclosure of Interest</h3> None declared
Health campaigners welcome government plan to phase out coal power
Authors: Gareth Iacobucci
Journal: BMJ (2016)

The UK Health Alliance on Climate Change has welcomed the government’s plan to phase out coal power by 2025.

A consultation document published on 9 November1 outlined how the government plans to fulfil its 2015 pledge2 to replace coal power with cleaner technology, such as gas, in a bid to reduce significantly emissions from the UK’s energy use.

The consultation—published by the Department for Business, Energy, and Industrial Strategy—set out a roadmap for closing unabated coal power stations by 2025. It also suggested …
VAMP/ThaCyDex: Velcade® (Bortezomib), Adriamycin, Melphalan and Prednisone Alternating with Thalidomide, Cyclophosphamide and Dexametasone as a Salvage Regimen in Relapsed Multiple Myeloma Patients
Authors: Enrique Colado, Maria-Victoria Mateos, Maria-Jose Moreno, Felipe de Arriba, Javier de la Rubia, Juan José Lahuerta, Pastora Iniesta, Maria Cruz Viguria, Ana Pilar Gonzalez, Ramón García-Sanz, Juan Olazabal, Jesús F San Miguel
Journal: Blood (2008)