THE NEWER ANTIHYPERTENSIVE DRUGS
Authors: P. W. C.
Journal: Annals of Internal Medicine (1953)

Editorial1 January 1953THE NEWER ANTIHYPERTENSIVE DRUGSP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-38-1-142 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptControl of hypertension by any of the measures hitherto available has presented a baffling problem. Diets low in sodium or otherwise restricted, psychotherapy, sympathectomy, and the administration of many different drugs have all yielded good results in individual cases or groups of cases. Many cases, however, fail to respond or quickly become refractory. The recent discovery of drugs which are much more effective in maintaining a lowered blood pressure constitutes a major advance, and their current availability makes the problem of using them properly of immediate practical importance.Hypertension is not a specific disease but rather a systemic reaction which...1 CampbellRobertson AE: Treatment of severe hypertension with hexamethonium bromide, Brit. M. J. 2: 804, 1950. CrossrefMedlineGoogle Scholar2 RestallSmirk PAFH: The treatment of hypertension with hexamethonium, New Zealand M. J. 49: 206, 1950. MedlineGoogle Scholar3 FriesFinnertySchnapperJohnson EDFAHWRL: The treatment of hypertension with hexamethonium, Circulation 5: 20-27, 1952. CrossrefMedlineGoogle Scholar4 Schroeder HA: Control of hypertension by hexamethonium and 1-hydrazinophthalazine, A. M. A. Arch. Int. Med. 89: 523-540, 1952. CrossrefGoogle Scholar5 Mills LC: Quoted by Schroeder.4 Google Scholar6 Fries ED: Effect of "sympatholytic" drugs on cardiovascular responses to epinephrine and norepinephrine in man, Circulation 3: 254-259, 1951. CrossrefMedlineGoogle Scholar7 Yonkman FF: Quoted by Wilkinson et al.8 Google Scholar8 WilkinsonBackmanHecht ELHHH: Cardiovascular and renal adjustments to a hypotensive agent (1-hydrazinophthalazine: Ciba BA-5968: Apresoline), J. Clin. Investigation 31: 872-879, 1952. CrossrefMedlineGoogle Scholar9 Schroeder HA: The effect of 1-hydrazinophthalazine in hypertension, Circulation 5: 28-37, 1952. CrossrefMedlineGoogle Scholar10 JohnsonFriesSchnapper RLEDHW: Clinical evaluation of 1-hydrazinophthalazine (C-5968) in hypertension with special reference to alternating treatment with hexamethonium, Circulation 5: 833-841, 1952. CrossrefMedlineGoogle Scholar11 Grimson KS: Caution with regard to the use of hexamethonium and "Apresoline," J. A. M. A. 149: 215-219, 1952. CrossrefMedlineGoogle Scholar12 Page IH: Treatment of essential and malignant hypertension, J. A. M. A. 147: 1311-1318, 1951. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPractical ambulatory therapy of functional constipationThe Blood Pressure Lowering Ability of Some Fractions of Rauwolfia serpentina Benth 1 January 1953Volume 38, Issue 1Page: 142-146KeywordsDietDrug administrationDrug discoveryDrug psychotherapyDrug regulationDrugsHypertensionSodiumSympathectomySystemic diseases ePublished: 1 December 2008 Issue Published: 1 January 1953 PDF downloadLoading ...