tbuckley/cabot-search huggingface dataset:
THU0050 Cardiovascular risk in korean patients with rheumatoid arthritis
Authors: C.-B. Choi, Y.-K. Sung, S.-K. Cho, S.-Y. Park, J. Shim, J.J. Kim, C.N. Son, S.-C. Bae
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) are at increased risk for cardiovascular diseases and it's the major cause of death. But, it is unclear if it also applies to the population with relatively low risk for cardiovascular diseases. <h3>Objectives</h3> We investigated the cardiovascular risk and their influencing factors in RA patients of Korean population. <h3>Methods</h3> Cardiovascular risk in 4,672 Korean RA patients enrolled from 2009 to 2010 in the Korean Observational Study Network for Arthritis (KORONA) cohort were assesed using the Framingham Score and systemic coronary risk evaluation (SCORE) for low cardiovascular risk countries. In KORONA cohort, patients are assessed for demographic characteristics, disease activity, functional status, quality of life, laboratory, and radiographic status. Although laboratory tests including lipid profile is strongly recommended at enrollment, HDL levels were missing in a nimber of patients and they were excluded in assessing the Framingham Score. <h3>Results</h3> A total of 1,228 patients were assessed for the Framingham Socre after excluding those with no information on the HDL level. Female constituted 85.8% of the patients and the mean age was 54.7±11.2 years. The mean DAS28-ESR was 3.7±1.3 and mean disease duration was 8.0±7.5 years. Mean Framingham Score was significantly higher in males with 11.6±3.5 compared to 10.7±6.1 in females (p=0.007). It increased with longer disease duration and it was significantly higher in patients with disease duration over 10 years with 12.1±5.1 compared to 10.0±6.2 in those with less than 5 years and 10.5±5.9 in 5 to 10 years (p&lt;0.001). A total of 4,187 patients were assessed for SCORE for low cardiovascular risk countries. Female constituted 85.4% of the patients and the mean SCORE was significantly higher in male with 3.1±2.8 compared to 0.85±1.2 in females (p&lt;0.001). Longer disease duration was also associated with significant increase in cardiovascular risk. It was more significant when the EULAR recommendations were applied. <h3>Conclusions</h3> Korean patients with RA are at increased risk for cardiovascular disease with longer disease duration increasing the risk. <h3>Disclosure of Interest</h3> None Declared
Circulating Factor Associated with Increased Glomerular Permeability to Albumin in Recurrent Focal Segmental Glomerulosclerosis
Authors: Virginia J. Savin, Ram Sharma, Mukut Sharma, Ellen T. McCarthy, Suzanne K. Swan, Eileen Ellis, Helen Lovell, Bradley Warady, Sripad Gunwar, Arnold M. Chonko, Mary Artero, Flavio Vincenti
Journal: New England Journal of Medicine (1996)

Heavy proteinuria and progressive renal injury recur after transplantation in up to 40 percent of patients with renal failure caused by idiopathic focal segmental glomerulosclerosis. A circulating factor may be responsible for this recurrence.
Treatment of Adult T-Cell Leukemia-Lymphoma with Zidovudine and Interferon Alfa
Authors: Olivier Hermine, Didier Bouscary, Antoine Gessain, Pascal Turlure, Veronique Leblond, Nathalie Franck, Agnes Buzyn-Veil, Bernard Rio, Elisabeth Macintyre, Francois Dreyfus, Ali Bazarbachi
Journal: New England Journal of Medicine (1995)

Human T-cell lymphotropic virus type I (HTLV-I)1 is the etiologic agent of adult T-cell leukemia-lymphoma.2 The serum of patients with this disease contains antibodies to HTLV-I,3 and there is monoclonal integration of HTLV-I proviruses in the malignant cells.4 The principal clinical features of adult T-cell leukemia-lymphoma5 are lymphadenopathy, hepatosplenomegaly, skin lesions, and hypercalcemia. Compromise of the immune system can allow opportunistic infection. The blood contains abnormal lymphocytes with characteristic indented or convoluted nuclei (``flower cells''). These malignant lymphocytes are activated CD4-positive T cells with increased expression of the alpha chain of the interleukin-2 receptor. Four different clinical subtypes of adult . . .
Abdominal-Wall Varices in the Budd–Chiari Syndrome
Authors: Xingshun Qi, Guohong Han
Journal: New England Journal of Medicine (2014)

A 57-year-old man with a 5-year history of intermittent edema of the legs was admitted to the hospital because of varices in the right abdominal and chest walls. The varices had been gradually increasing in size and number over a period of 18 years.
Abstract IA-8: p53: From structure to drug discovery
Authors: Alan R. Fersht
Journal: Cancer Research (2009)

Abstract The ability to produce quantities of stable p53 and the use of new biophysical methods are giving novel insights into the oligomerization of p53 and how this may be important in its regulation. We have discovered that the association and dissociation of p53 is extremely slow and can take more time than the half-life of p53 in the cell. The rate of association equilibria can be catalyzed by the binding to DNA and proteins and also be regulated by the binding to proteins, such as members of the S100 family, for example. I will discuss these phenomena and the latest developments in rescuing unstable oncogenic mutants of p53 by lead compounds for novel anti-cancer drugs. Citation Information: Cancer Res 2009;69(23 Suppl):IA-8.
Clinical impact of pathological axillary downstaging in locally advanced breast cancer after primary systemic chemotherapy.
Authors: M Zambetti, G Bianchini, G Bianchi, G Mariani, A Moliterni, P Mariani, E De Benedictis, P Valagussa, M Greco, L Gianni
Journal: Cancer Research (2009)

Abstract Abstract #5103 Background Primary Systemic Chemotherapy (PSC) can result in pathologic axillary downstaging even in Locally Advanced Breast Cancer (LABC), which is generally associated with unfavorable prognosis and high incidence of nodal metastases. Aims were to evaluate: the clinical and biological factors associated with the likelihood of obtaining negative pathological nodes (pN0); the relationship between outcome and axillary nodal status at diagnosis (cN) and at surgery after PSC (pN).&amp;#x2028; Methods Women with LABC consecutively treated at the Istituto Nazionale Tumori in Milan from 1991 to 2007 were evaluated. Patients received PSC containing Doxorubicin ± Paclitaxel (+ adjuvant or neoadjuvant CMF) and endocrine therapy ± trastuzumab. Fixed right-censoring at 5 years was performed. Associations with Disease-Free Survival (DFS) and Overall Survival (OS) were evaluated using Kaplan-Meier (log-rank test) and Cox regression analysis. All confidence intervals are at 95%.&amp;#x2028; Results 451 women submitted to surgery and complementary RT were included in the analysis. 68% of surviving patients were followed for at least 5 yrs. 5y-DFS and OS were 51% (46-57%) and 70% (65-75%) respectively. ER negative, PGR negative, high grade and age &amp;lt;50 yrs were correlated with likelihood of pN0 at univariate logistic analysis, while ER negative only (OR 3.49, CI 1.65-7.66; p=0.001) retained significant role in the multivariate analysis.&amp;#x2028; Relationship between axillary status and outcome are shown in table 1.&amp;#x2028; &amp;#x2028; Multivariate Cox regression analysis showed that positive nodes at diagnosis (HR 2.13, CI 1.07-4.22; p=0.03) and at surgery (2.84, CI 1.77-4.56; p&amp;lt;0.001), negative PGR (HR 1.79, CI 1.12-2.86; p=0.01), inflammatory status (HR 1.51, 1.02-2.23; p=0.04) and age &amp;lt; 50 yrs (HR 2.23, CI 1.58-3.16; p&amp;lt;0.001) were independent predictors of DFS. Multivariate analysis for OS demonstrated positive nodes at surgery (HR 3.46, 1.80-6.67; p&amp;lt;0.001), negative PGR (HR 2.21, CI 1.16-4.20; p=0.01) and age &amp;lt; 50 yrs (HR 2.00, CI 1.26-3.17; p=0.003) as significant variables. Pathologic complete response in breast was not significant in both multivariate analysis.&amp;#x2028; Conclusions Axillary downstaging was obtained in a significant proportion of patients with LABC. pN0 status after PSC identifies a clinical subgroup with better prognosis irrespectively of locally advanced disease and, in this subgroup of patients, it is a prognostic factor stronger than pathologic complete response in the breast. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 5103.
AB0232 A randomized, double-blind trial of intravenous immunoglobulin in diffuse cutaneous systemic scleros
Authors: K. Takehara, H. Ihn, S. Sato
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrotic changes in skin and other organs involving excessive collagen deposition. Intravenous immunoglobulin (IVIG) suppressed collagen content and expression in a murine model. IVIG has been also reported to reduce skin stiffness in SSc patients in several open trials. <h3>Objectives</h3> To examine the efficacy and safety of IVIG in treating diffuse cutaneous SSc in a multicenter, randomized, placebo-controlled, double-blind trial. <h3>Methods</h3> It is first time trial in Japan, which was conducted in SSc at 17 sites. Patients with diffuse cutaneous SSc were recieved IVIG (400mg/kg/day for 5 consecutive days: a single course of therapy) or placebo intravenously. The primary outcome measure was the change of modified Rodnan’s total skin thickness score (MRSS) between before and 12 weeks after treatment. <h3>Results</h3> The changes (mean±SD) of MRSS between before and 12 weeks after treatment were -3.3±4.2 (n=31) in the IVIG group versus -4.2±4.6 (n=31) in the placebo group. The difference between groups was not significant (p=0.3257). Histological evaluation revealed that the percent changes (mean±SD)of dermal fibrotic thickness were -2.23±34.48 (n=21) in the IVIG group versus 7.51±25.55 (n=22) in the placebo group. The change in the IVIG group was larger, but no difference between groups (p=0.0985). Adverse event rates of the IVIG group was higher than the placebo group (32.3% versus 12.5%), but absence of significant adverse events was observed. Retreated IVIG treatment for patients revealed the decrease of MRSS less than 5 points in this study showed the significant improvement of MRSS in a long-term observational study. <h3>Conclusions</h3> A single course of IVIG treatment didn’t exhibit the improvement of MRSS in diffuse cutaneous SSc. However, MRSS decreased significantly by two courses of IVIG treatment. It is suggested that repeated IVIG treatment of more than two courses should be considered in some patients. Further trials are needed to evaluate the effect of IVIG when treated in different regimens. <h3>Disclosure of Interest</h3> K. Takehara Consultant for: Benesis, H. Ihn: None Declared, S. Sato: None Declared
The Acidosis of Cholera
Authors: Fong Wang, Thomas Butler, G.H. Rabbani, Paul K. Jones
Journal: New England Journal of Medicine (1986)

To study the metabolic acidosis that occurs during the diarrhea of cholera, we examined the serum anion gap in 21 patients with hypovolemic shock due to Vibrio cholerae infection. Measurements of serum electrolytes, as well as divalent cations and the anionic contributions of serum proteins, lactate, phosphate, and serum creatinine, were made at the time of admission, after rehydration, and during convalescence. At the time of admission, the mean serum concentration of sodium was 134.8 mmol (meq) per liter, that of chloride was 103.2 mmol per liter, and that of bicarbonate was 11.4 mmol per liter; the mean anion gap was 20.2 mmol per liter. The mean serum creatinine concentration was 2.48 mg per deciliter. The low serum bicarbonate level and the high serum anion gap were corrected by rehydration. The increased serum anion gap was caused by hyperproteinemia, lactic acidemia, and hyperphosphatemia, with anionic contributions to the rise in anion gap estimated as protein, 5.5 meq per liter; lactate, 2.5 meq per liter; and phosphate, 2.5 meq per liter. The hyperproteinemia was attributed to dehydration, the lactic acidemia to shock, and the hyperphosphatemia to acidosis and transient renal failure. The mean concentrations of serum calcium and magnesium were slightly elevated but did not affect the increased anion gap. These results indicate that severe cholera causes acidosis with relatively little change in serum chloride but an increased serum anion gap. The acidosis is more profound than would be expected on the basis of stool losses of bicarbonate, because of superimposed lactic acidemia and renal failure.
Case 23-1998
Authors: Jonathan M. Rosen, Eugene J. Mark
Journal: New England Journal of Medicine (1998)

Presentation of CaseA 74-year-old man was admitted to the hospital because of recurrent lymphoma, with paraplegia.Nine and a half years earlier, a computed tomographic (CT) scan of the head had shown a mass in the base of the tongue, with left cervical lymphadenopathy. Biopsy of the mass revealed follicular lymphoma, predominantly of the small-cleaved-cell type. Staging showed no evidence of lymphoma elsewhere. Radiation (4500 cGy) was administered, and an evaluation seven months later showed no evidence of disease.Seven months before admission, hepatosplenomegaly, leukopenia, and thrombocytopenia were detected. A bone marrow biopsy showed B-cell blasts — a finding . . .
Danazol Increases Factor VIII and Factor IX in Classic Hemophilia and Christmas Disease
Authors: Harvey R. Gralnick, Margaret E. Rick
Journal: New England Journal of Medicine (1983)

We gave danazol (600 mg per day orally for 14 days), an attenuated androgen, to four adults with classic hemophilia and one adult with Christmas disease. The levels of factor VIII in the patients with classic hemophilia ranged from 1 to 3 per cent before treatment and rose to 3 to 8 per cent during the treatment period. The level of factor IX in the patient with Christmas disease rose from 5 to 14 per cent. The rise in clotting-factor activity was usually observed within five to six days after the initiation of therapy and peaked between 7 and 13 days. The drug had no untoward effects. During the 70 patient-days of therapy, only two patients required plasma products, each on one occasion. These data suggest that danazol therapy may decrease the hemorrhagic tendency and reduce the need for transfusions of plasma products in classic hemophilia and Christmas disease. Controlled clinical trials will be required to establish its value in these applications.
Abstract 2998: MicroRNA expression signatures in human ovarian tumor progression
Authors: Jian-jun Zhao, William Kong, Jianhong Lin, Jennifer Wey, Hua Yang, domenico coppola, Yi-Chun Lee, Robert Wenham, Johnathan Lancaster, Thomas Sellers, Jin Q. Cheng
Journal: Cancer Research (2010)

Abstract Differential expression of a number of miRNAs has previously been detected between normal ovaries and epithelial ovarian cancer (EOC). However, miRNA expression signatures have not been demonstrated between primary human ovarian surface epithelial (HOSE) cell, cystadenoma, low malignant potential (LMP) ovarian tumor and ovarian carcinoma as well as fallopian tube. Here, we performed miRNA profiling in normal primary OSE cells, normal fallopian tube and ovarian tumors, including 7 cystadnomas, 6 LMP and 49 ovarian carcinomas, as well as 15 ovarian cancer cell lines and 5 HIOSE cell lines. While deregulated dozen miRNAs were observed in different histological types of cysadenoma, LMP and ovarian carcinoma compared to primary OSE and fallopian tube, there are no significantly common changed miRNAs between serous adenoma and LMP, as well as between mucinous adenoma and LMP. However, 3 miRNAs were co-downregulated and 7 miRNAs were co-upregulated in serous LMP and carcinoma. When comparing mucinous LMP and carcinoma, only 3 miRNAs were co-deregulated. In addition, 3 and 6 miRNAs were co-deregulated in mucinous and serous adenoma and carcinoma, respectively. While miRNA expression patterns are distinct among four histological types of ovarian carcinoma examined, upregulation of miR-221/222 family was found to have significant poor prognosis value in serious carcinoma (p&amp;lt;0.05). These results support the notion that majority of ovarian carcinoma are derived neither from cystadenoma nor from LMP. Further cluster analysis suggests that the serious ovarian cancer may be derived from fallopian tube or/and OSE. Also our data suggest that commonly deregulated miRNAs between adenoma, LMP and carcinoma could serve as not only early markers but also initiation pathogenetic factors in this malignancy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2998.
Prise en charge endoscopique des sténoses anastomotiques biliaires (SA) après transplantation hépatique (TH)
Authors: M Azouaoui, P Bauret, JC Valats, M Bismuth, A Herrero, F Navarro, GP Pageaux
Journal: Endoscopy (2011)

Introduction: Les complications biliaires les plus fréquemment observées après TH sont les SA. La prise en charge endoscopique tend à devenir le traitement de référence.
PMO-059 Parenteral nutrition: audit of usage in a district general hospital without a nutrition support team
Authors: A Phillips, J Brown, K Hinton, I Gee
Journal: Gut (2012)

<h3>Introduction</h3> Parenteral nutrition (PN) is well known to have possibility of serious sequelae, in particular from catheter related sepsis (CRS). Multiple studies have demonstrated that a Nutrition Support Team (NST), in particular a Nutrition Support Nurse (NSN), can reduce inappropriate PN as well as reducing CRS rates (Kennedy <i>et al</i> 2005). The aim of this audit was to document PN usage in a district general hospital without a NST or NSN. <h3>Methods</h3> All patients in whom PN was initiated in 2010 at Worcester Royal Hospital were assessed retrospectively by case note review by a single author (AMP). A list of all patients who had received PN was kept by the Pharmacy department, ensuring a 100% pick up rate. Appropriate PN indications were defined according to the NICE guidelines. Patients with a functional and usable GI tract (capable to absorb adequate nutrients via appropriate enteral tube access), patients in whom dependence on PN was anticipated to be &lt;5 days and patients whose prognosis did not warrant aggressive nutritional support were defined as receiving inappropriate PN. CRS was judged to have occurred when the patient had a temperature of ≥38.0°C along with either a subsequent positive line tip culture or positive blood cultures in the absence of any other potential source of sepsis. <h3>Results</h3> 61.4% of the patients were male. The median age at commencement of PN was 67.1 (IQR 59.9–80.3). There were 101 episodes of PN, with a median duration of PN of 7 days (IQR 5–14). A total of 1214 days of PN were administered. Full information was available for 92 of these episodes, a total of 1093 days. The majority of PN was given via non-tunnelled central venous catheters (58.3%) with a further 23.7% by Hickmann line, and 13.4% peripherally. Sixty-eight of the episodes were assessed to have been initiated for appropriate indications: 50% of these due to ileus, 19.1% due to obstruction and 14.7% due to fistulae. Twenty-four episodes, totalling 182 days of PN, were judged to have been inappropriate, predominantly due to inadequate consideration being given to enteral tube access. CRS complicated 16 of the episodes (17.4%) and there were 18 CRS events, equating to 16.5 events/1000 catheter days. The majority of these (16/18) were due to coagulase negative <i>S aureus</i>. <h3>Conclusion</h3> Inappropriate PN and CRS rates are at the level that would be expected in a hospital where there is no NST. Increased vetting of PN referrals and more effective training in line care that would come with a formal NST could have cost benefits for the trust. <h3>Competing interests</h3> None declared.
Bone Marrow Biopsy and Bone Scan To Detect Skeletal Metastases
Authors: I Mirza, B Cuello, A Ramachandran, W Johns
Journal: Clinical Nuclear Medicine (2001)

This study correlates the findings of bone marrow biopsy with those of bone scan in patients with common cancers and highlights the comparable sensitivities of the two methods at the authors’ institution. The results show that bone scintigraphy may be slightly more sensitive than bone marrow examination for the detection of carcinomatous metastases. This experience suggests that institutions should devise clinical pathways based on their testing sensitivities and patient characteristics. These considerations will ultimately result in better and more cost-effective treatment of these patients.
Abstract 4857: Improved technology for ribosomal RNA (rRNA) removal from formalin-fixed paraffin-embedded (FFPE) total RNA
Authors: Roy Sooknanan, Agnes Radek, John Hitchen, Anupama Khanna
Journal: Cancer Research (2011)

Abstract Deep, massively parallel sequencing of cDNA generated from RNA (“RNA-Seq”) is rapidly gaining momentum for transcript profiling, discovery of novel transcripts, and identification of alternative splicing events. Current methods for making sequencer-specific di-tagged DNA fragment libraries for RNA-Seq typically comprise first, preparing rRNA-depleted RNA from total RNA samples that are usually of good quality followed by the synthesis of the di-tagged cDNA sequencing templates. In the past few years however, it has also become evident from microarray and qPCR studies that formalin-fixed paraffin-embedded (FFPE) cancer tissues hold valuable secrets about diseased states. However, RNA-Seq libraries prepared from such highly fragmented FFPE RNA cancer samples yield limited information since these libraries contain a majority of rRNA reads, which decreases sequencing depth and coverage. Current commercially available rRNA-removal kits are not designed to remove fragments of rRNA, which poses a significant limitation for preparing highly informative RNA-Seq libraries from FFPE RNA samples. Here, we present RNA-Seq results obtained using a novel rRNA removal technology (“Ribo-ZERO™”) and a novel, ligation-free process for preparing directional di-tagged DNA fragment libraries (“ScriptSeq™ Technology”) for RNA-Seq. Using these methods, directional di-tagged DNA fragment libraries can be prepared in about 6 hours from either intact or fragmented (e.g., FFPE) total RNA samples (as little as 100 ng FFPE total RNA sample required). Less than 2 % of the sequence reads from libraries generated from total RNA from either intact or FFPE samples map to rRNA sequences (28S, 18S, 5.8S and 5S). This reduction in rRNA sequence reads from FFPE RNA samples improves sequence depth and coverage, and increases the percentage of uniquely mapped reads, increasing the information obtained from these diseased samples. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4857. doi:10.1158/1538-7445.AM2011-4857