tbuckley/cabot-search huggingface dataset:
Foreign Bodies in the Air-Passages
Authors: G. Padley
Journal: BMJ (1861)

The same treatment was continued through the next ,day; biut he gradually sank, and diedl on the 30th.'There wvas no expectoration throuahout.AUToPrsY, twenty-one hours after death.The sternal end of the clavicle was found to rest entirely on the upper bone of the sternum, thie interarticular cartilage 'being carried with it.The left pleuiral cavity contained a pint or more of bloody fluid.The lung was collapsed, ,and almiost black.On its posterior surface were two lacerations, neithier of theiii large.The third, fourth, fifth, sixthl, and seventh ribs on this side were broken near their angles, projecting sharply and roughly into the pleural cavity.The sixth rib was also separated fromo its cartilage.The fourth and fifth ribs on the right side were broken about miidway between the sternum andl their anigles.The pleura on this side was not injuired, and the lun1g itself was healthy.Both condyles of thie humerus were broken off; but there was no other injury, thie radius and ulna being intact and in proper position.
Reply
Authors: Chien‐Hsieh Chiang, Kuo‐Chin Huang
Journal: Hepatology (2014)

We appreciate the valuable comments made by Dr. T.J.S. Cross. Although the patient-reported questionnaire is not totally accurate, it remains a useful tool in community-based, large-scale study of multiple screening sites. As mentioned in our article, some residual confounding might come from the disease duration and medications used.1 There have been a few analyses using claims for a database reporting the association of each class of antidiabetic agents and hepatocellular carcinoma (HCC) risks.2 However, the research estimating the association of a class of antidiabetic agents with deaths from HCC is still lacking. We could not get liver tissues of all participants in this community-based nation-wide cohort to eliminate the presence of occult hepatitis B virus (HBV) infection. Furthermore, the direct contribution of occult HBV infection to HCC-related death has not yet been established in those without physician-diagnosed viral hepatitis. There were 2,686 deaths during the follow-up of all participants, including 235 from HCC and 549 cardiovascular deaths. Among our diabetics, there were 40 HCC-related deaths and 73 cardiovascular deaths. Even if a participant had been dead with concurrent HCC and cardiovascular disease, only one primary cause of death would be coded in death certificates of Taiwan. Besides, our subjects with HCC-related deaths were younger than those with cardiovascular deaths (66.1 vs. 70.7 years). Therefore, little research could verify the real impact of competing risks, especially if the diagnosis of HCC had never been made until death. We prefer that other unclear mechanisms should be elucidated for the observed protective effect of dyslipidemia. Finally, we agreed deeply that prevention of diabetes is crucial both to prevent HCC mortality and cardiovascular death. Chien-Hsieh Chiang, M.D., M.P.H.1,2 Kuo-Chin Huang, M.D., Ph.D.1,3 1Department of Family Medicine National Taiwan University Hospital and College of Medicine Taipei, Taiwan 2Department of Community and Family Medicine National Taiwan University Hospital Yun-Lin Branch Yunlin, Taiwan 3Graduate Institute of Clinical Medical Science China Medical University Taichung, Taiwan
Analysis of resilience scores of breast cancer patients undergoing ambulatory chemotherapy treatment.
Authors: A. F. Ferreira Filho, O. C. Junior, D. L. Da Silva, M. A. de Souza, I. M. Tavares Cavalcante, A. P. Wunder
Journal: Journal of Clinical Oncology (2010)

e19681 Background: Resilience is a positive psychological characteristic that enhances individual and group adaptation, helping the adjustment to stress and misfortune. Research with quantitative analysis of resilience is still incipient in the breast cancer patients (BCP) population. The objective of this study is to evaluate and describe resilience scores (RS) in a population of BCP undergoing chemotherapy treatment on ambulatorial basis. Methods: The resilience questionnary was applied by oncology nurses to 29 women with BCP undergoing ambulatory chemotherapy treatment. Individual RS were measured by the Wagnild and Young Scale, validated for portuguese language from Brazil. Possible scores range from 25 to 175 with higher scores reflecting higher resilience. The study was approved by the Ethics Comitte and all patiens signed the informed consent form. Results: The mean age of the 29 patients (PTS) was 52 ± years (range 32-73). For all PTS, the mean RS was 139 ± 13 (111-172), displaying a statistically normal distribution of individual scores. The intent of treatment was palliative in 20 PTS (69%) and curative (adjuvant or neoadjuvant) in 9 (31%). There were 14 PTS (48%) with ≥ 50 years. In this group of patients (≥ 50), chemotherapy was more frequentely used with palliative intention (14/16), when compared to the younger PTS (6/13), (P = 0.041). The mean total RS was 136 for PTS with ≥ 50 years and 143 for PTS < 50 years (P = 0.13). No statistical differences in mean RS were detected between between patients receiving palliative (mean 137) or curative (mean 143), chemotherapy treatment (P = 0.2). Conclusions: The individual RS in this cohort of ambullatory BCP display a normal distribution. We did not find statistical differences in resilience scores between BCP treated with palliative intention compared to BCP receiving treatment with curative intention. Despite undergoing treatement with palliative intention more frequently, patients with ≥ 50 years displayed equivalent resilience scores when compared to younger patients. Further research is necessary in this field to confirm and clarify the implications of these findings. No significant financial relationships to disclose.
Abstract P3-13-07: Radiofrequency ablation (RFA) is a promising treatment option for primary breast cancer: Experience in 386 Japanese breast cancer patients
Authors: M Takahashi, T Ito, S Oura, S Nagamine, N Yamamoto, N Yamamichi, M Earashi, H Doihara, S Imoto, S Mitsuyama, K Akazawa
Journal: Cancer Research (2016)

Abstract Background. Radiofrequency ablation (RFA) is used for the treatment of various solid tumors. Several small experiences have reported as a primary treatment for breast cancer using RFA. However, the clinical benefits remain uncertain. We retrospectively studied 386 patients and analyzed their RFA-related complications and outcomes. Methods. A clinical database was constructed from 10 institutions. RFA was performed using an electrical generator connected to a single cooled-tip electrode or multiple electrodes. Adjuvant systemic therapy and whole breast radiation were administered according to the clinicopathological background of each patient. Follow-up periods ranged from 1 to 90 months (mean 45.4 months). RFA-related complications and risk factors for in-breast recurrence after RFA were evaluated. Variables evaluated included patient characteristics, pre- and post-operative imaging modalities, tissue sampling modalities, and RFA-related factors. Results. Skin burns were observed in 7 patients (1.8 %) and RFA-induced damage to the nipple-areolar complex in 7 patients (1.8 %). Persistent induration of the breast after RFA was observed in 137 patients (35.5 %). Eleven patients (2.8 %) developed in-breast recurrence. In-breast recurrence was more frequent in patients with tumor size &amp;gt;2.0 cm, ER-negative tumor, HER2-positive tumor, positive nodes, no breast irradiation and adjuvant chemotherapy. Conclusions. Skin burns were a major problem after RFA, but the frequency of burns was relatively low. Breast induration was also developed, but it did not bring harmful effect to the patients with this complication. We conclude that RFA is a promising treatment option for solid T1 breast cancer without malignant potential. Citation Format: Takahashi M, Ito T, Oura S, Nagamine S, Yamamoto N, Yamamichi N, Earashi M, Doihara H, Imoto S, Mitsuyama S, Akazawa K. Radiofrequency ablation (RFA) is a promising treatment option for primary breast cancer: Experience in 386 Japanese breast cancer patients. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-13-07.
Psychological dimensions of internation dependency
Authors: S R Pieczenik
Journal: American Journal of Psychiatry (1975)

The author analyzes the psychological consequences of international dependency, advancing 13 propositions as clues for a heuristic understanding of the dynamics of dependent relationships between nations. He believes that these relationships must be understood before they can be improved. The author proposes coequal alliances and multinational aid as desirable alternatives to existing political-economic-military strategies.
Histone Deacetylase Inhibition in Prostate Cancer Triggers miR-320–Mediated Suppression of the Androgen Receptor
Authors: Shinya Sato, Keisuke Katsushima, Keiko Shinjo, Akira Hatanaka, Fumiharu Ohka, Shugo Suzuki, Aya Naiki-Ito, Norihito Soga, Satoru Takahashi, Yutaka Kondo
Journal: Cancer Research (2016)

Abstract Targeting androgen receptor (AR) by pharmacologic intervention is one of the effective approaches for treatment of malignant prostate cancers. Histone deacetylase (HDAC) alters the epigenetic status of tumor-associated genes, including those for miRNAs (miRNA), and affects the behavior of cancers. Here, we examined the molecular effects of a HDAC inhibitor, OBP-801, on AR expression and tumor cell growth in prostate cancers. Treatment with OBP-801 efficiently suppressed cell growth of three prostate cancer lines (22Rv1, VCaP, and LNCaP), together with AR downregulation, regardless of their hormone sensitivity. Intriguingly, this effect by OBP-801 was not due to decreased transcriptional activity of the AR gene, but due to posttranscriptional regulation, namely by miRNA-mediated suppression. Among the upregulated miRNAs after OBP-801 treatment in the three prostate cancer cell lines, miR-320a, whose expression was significantly correlated with prognosis of prostate cancers (P = 0.0185), was the most closely associated with AR expression. An miR-320a mimic suppressed AR protein expression together with growth suppression, while anti-miR-320a oligonucleotide significantly abrogated the growth suppression by OBP-801 treatment. FISH analysis revealed that miR-320a was highly expressed in human normal prostate luminal cells, but was rarely expressed in prostate cancer cells. In an AR-dependent prostate tumorigenic rat model, OBP-801 treatment profoundly increased miR-320a expression and repressed prostate tumorigenesis. Our data demonstrated that OBP-801 effectively suppressed AR activity via epigenetic upregulation of miR-320a, which resulted in tumor cell growth suppression of prostate cancers. OBP-801 may be a potent AR-targeting therapeutic reagent in AR-positive prostate cancer regardless of androgen dependency. Cancer Res; 76(14); 4192–204. ©2016 AACR.
464P Comparision of irinotecan/cisplatin with etoposide/cisplatin in North-West Indian population with extensive-stage disease small-cell lung cancer
Authors: S.K. Beniwal, S. Narayan, G.S. Rao, M.K. Singhal, S.L. Jakher, S.R. Maheria, N. Sharma, H.S. Kumar, A. Sharma
Journal: Annals of Oncology (2015)
Possible psychogenic fever of 103.5 degrees F in a patient with borderline personality disorder
Authors: G N McNeil, L H Leighton, A M Elkins
Journal: American Journal of Psychiatry (1984)

The authors describe a 24-year-old woman with borderline personality disorder and prolonged fever of unknown origin. After an extensive search for a fever source, they noted that her temperature responded to pseudoseizures and to phenobarbital.
Allogeneic hematopoietic cell transplantation for multiple myeloma in Europe: trends and outcomes over 25 years. A study by the EBMT Chronic Malignancies Working Party
Authors: M Sobh, M Michallet, G Gahrton, S Iacobelli, A van Biezen, S Schönland, E Petersen, N Schaap, F Bonifazi, L Volin, E Meijer, D Niederwieser, J El-Cheikh, R Tabrizi, N Fegeux, J Finke, D Bunjes, J Cornelissen, H Einsele, B Bruno, M Potter, R Fanin, M Mohty, L Garderet, N Kröger
Journal: Leukemia (2016)
Successful retrieval of a foreign body embedded in the wall of the piriform sinus by mucosal incision
Authors: Huimin Guo, Xiaoping Zou, Wen Li, Qian Wang, Erhua Wang, Tingsheng Ling
Journal: Endoscopy (2015)

A 66-year-old woman came to the emergency room with symptoms of foreign-body sensation and pharyngeal pain after the accidental ingestion of a foreign body during breakfast, but she had no idea of what she had swallowed. Computed tomography of the neck, performed to confirm the presence of a foreign body and clarify its relationship with surrounding structures, showed a metallic foreign body in the right pharyngeal cavity ([Fig. 1 a]), and synthesized three-dimensional images of the structures of the neck showed a foreign body located at the level of the fifth cervical vertebra ([Fig. 1 b]). Esophagogastroscopy along the right piriform sinus revealed a needle-like foreign body with one end embedded in the wall ([Fig. 2]).
PWE-033 The Incidence and Cost of Unexpected Hospital Attendance Following Elective Outpatient Flexible Sigmoidoscopy: Abstract PWE-033 Table
Authors: H Gordon, J H Brindley, C Zheng, J Graby, M A Abdullah, J Mawdsley, I Beveridge, K Monahan
Journal: Gut (2013)

<h3>Introduction</h3> Outpatient flexible sigmoidoscopy is an increasingly utilised investigation shown to be effective in the detection and prevention of bowel cancer. The procedure is thought to entail a low risk of complications. However, recent literature suggests the complication rate of other endoscopic procedures may be up to 10 fold that traditionally quoted (1). The true complication rate of flexible sigmoidoscopy is of particular importance as the UK is introducing the Bowel Cancer Screening Programme (BCSP) by which all citizens will be offered the procedure at age 55. <h3>Methods</h3> The aim of this study was to identify the morbidity and related healthcare costs of unexpected hospital attendance following outpatient flexible sigmoidoscopy. An observational study of A&amp;E attendances and admissions occurring within 14 days of all outpatient flexible sigmoidoscopies which took place in 2011 was conducted. All procedures took place at West Middlesex University Hospital, London. Data was collected using the hospital’s electronic records system, enterpriseCAMIS®. Cases were analysed to assess whether reattendance could be attributed to the procedure, and healthcare costs were determined. <h3>Results</h3> Of the 1137 outpatient flexible sigmoidoscopies performed, 18 patients (1.58%) presented to A&amp;E within 14 days. Only 2 of these attendances were thought to be related to the procedure (0.18%). 1 case resulted in a 5 day admission due to bleeding post polypectomy. The second A&amp;E attendance was also due to bleeding. The cost of the above admission was £4,682. Including the related A&amp;E attendance, the total financial burden of related reattendance following flexible sigmoidoscopy was approximately £4,827 in 2011. This equates to an additional cost of £4.25 per procedure. Cost of hospital attendance within 14 days of outpatient flexible sigmoidoscopy (WMUH 2011, n = 1137): <h3>Conclusion</h3> This study suggests outpatient sigmoidoscopy is relatively safe, with complications necessitating reattendance occurring following 0.18% procedures. The financial burden of hospital reattendance within our UK based study population was minimal, supporting the cost effectiveness of extending services for National bowel cancer screening programmes. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> Leffler D A, Kheraj R, MD; Garud S, Neeman N, Larry A, Nathanson A, Kelly C P, Sawhney M, Landon B, Doyle R, Rosenberg S, Aronson M; The Incidence and Cost of Unexpected Hospital Use After Scheduled Outpatient Endoscopy, <i>Arch Intern Med</i><i>.</i> 2010 Oct 25; 170(19):1752–7
Intraperitoneal chemotherapy for ovarian carcinoma.
Authors: R C Shepard
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.5.685 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2709092 Intraperitoneal chemotherapy for ovarian carcinoma. R C ShepardxR C ShepardSearch for articles by this author https://doi.org/10.1200/JCO.1989.7.5.685 PDF "Intraperitoneal chemotherapy for ovarian carcinoma.." Journal of Clinical Oncology, 7(5), p. 685© 1989 by American Society of Clinical Oncology
Lymphoproliferative Diseases of Fowl: Alteration in Lactate Dehydrogenase Isozymes Associated With Lymphoblastic Leukemia (JM-V)&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: M. L. Adams, A. J. Kenyon, N. D. Jones, N. F. Schmidt, S. N. Kim
Journal: JNCI Journal of the National Cancer Institute (1971)

This study of serum lactate dehydrogenase (LDH) isozymes in day-old chicks inoculated with blood from birds affected with JM-V lymphoblastic leukemia revealed a 14- to 22-fold increase in total LDH activity. Electropherograms demonstrated that the increased serum activity was due mainly to increased levels of isozymes LDH1 and LDH2. (The LDH isozymes are abbreviated LDH1 to LDH5, where at alkaline pH LDH1 has the greatest anodal migration.) To establish the origin of the increased levels of isozymes, isozyme patterns from liver, heart, spleen, bursa, and circulating lymphoblasts were compared. As expected, there was a high degree of similarity between the serum isozyme pattern of leukemic birds and extracts of lymphoid organs (spleen and bursa), as well as extracts of cultured leukemic lymphoblastic cells from affected birds. Serum isocitrate dehydrogenase activity increased tenfold in the affected chicks and paralleled the rise in LDH. On the other hand, serum glutamate-oxalate transaminase levels only moderately increased. This appeared to be associated with lymphostasis in the liver and disruption of hepatic structures by infiltrating lymphoblasts.
First line trastuzumab- or lapatinib-based therapy in her2-positive metastatic breast cancer patients after prior (NEO)adjuvant trastuzumab
Authors: M. Vaglica, M. Vaglica, M. Lambertini, A. Ferreira, F. Poggio, F. Puglisi, F. Sottotetti, F. Montemurro, E. Poletto, E. Pozzi, E. Risi, A. Lai, E. Zanardi, V. Sini, S. Ziliani, G. Minuti, S. Mura, D. Grasso, I. Ferrarini, P. Pronzato, L. Del Mastro
Journal: Annals of Oncology (2015)
Comments on the Analysis of Dose-Response Data in Experimental Carcinogenesis
Authors: Seymour H. Wollman
Journal: JNCI Journal of the National Cancer Institute (1955)

Comments on the Analysis of Dose-Response Data in Experimental Carcinogenesis Get access Seymour H. Wollman Seymour H. Wollman National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 1, August 1955, Pages 195–204, https://doi.org/10.1093/jnci/16.1.195 Published: 01 August 1955 Article history Received: 31 January 1955 Published: 01 August 1955
New York under the Rivers decision: an epidemiologic study of drug treatment refusal [published erratum appears in Am J Psychiatry 1991 Oct;148(10):1427]
Authors: J M Zito, T J Craig, J Wanderling
Journal: American Journal of Psychiatry (1991)

To determine the characteristics of cases of drug treatment refusal under the Rivers decision, which mandated court adjudication of such cases, the authors made a retrospective study of all applications for court review during 1 year in New York State inpatient facilities.Sociodemographic and clinical characteristics of these 473 cases were compared with those of the 41,535 cases during the same period in which no court review was requested.A 1% prevalence of applications requesting court review for nonemergency administration of medication over objection was found. The patients who refused medication were more likely than the comparison patients to have a crime-associated commitment status, a diagnosis of schizophrenia, and fewer previous hospital days, and they were more likely to be discharged. Medication refusers for whom applications for court review were submitted had relatively longer hospitalizations than the rest of the patients. Almost one-third of the applications submitted were withdrawn before court hearings, yielding a 0.7% prevalence of court-reviewed applications. Ninety-two percent of these applications for medication over objection were approved with virtually no change in the requested orders.The study findings demonstrate that a front-end judicial determination of competency to refuse medication results in a time-consuming procedure which fails to ensure real due process or provide individualized alternative treatment. A two-tier system with in-house clinical review preceding judicial review is proposed to remedy the deficiencies of the current system.
Abstract PR03: A lncRNA regulates DNA repair by homologous recombination
Authors: Vivek Sharma, Simran Khurana, Nard Kubben, Kotb Abdelmohsen, Philipp Oberdoerffer, Myriam Gorospe, Tom Misteli
Journal: Cancer Research (2016)

Abstract Introduction: Long non-coding RNAs (lncRNAs) have been shown to contribute to DNA damage response (DDR) by regulating gene expression. However, very little is known about the role that lncRNAs play in regulating DNA repair. In this study we characterized a lncRNA that regulates DNA repair by Homologous recombination (HR) by modulating recruitment of DNA repair factors at the sites of DNA damage. Experimental procedures: Control or DNA damage treated cells were processed for gene expression analysis, qPCR, live cell imaging, Immunochemistry, Western blotting, FISH and RNA Immunoprecipitation. Results: Using a genome-wide microarray screen we identified a novel ubiquitously expressed lncRNA, DDSR1 (DNA damage-sensitive RNA 1), which is induced upon DNA damage by several DNA double-strand break (DSB) agents. DDSR1 induction upon DNA damage is dependent on the ATM-NF-kB pathway. Loss of DDSR1 impairs cell proliferation, DDR signaling and reduces DNA repair capacity by homologous recombination (HR). The HR defect upon DDSR1 knockdown is characterized by aberrant BRCA1 and RAP80 accumulation at DSB sites. DDSR1 interacts with hnRNPUL1, an RNA-binding protein involved in HR. Loss of hnRNPUL1 also results in aberrant BRCA1 and RAP80 recruitment at DSB sites. Our results indicate that DDSR1/hnRNPUL1 depletion results in HR inhibition due to reduced end resection caused by aberrant BRCA1 and RAP80 at DSBs. Conclusions: Our results reveal a previously unknown lncRNA involved in regulation of DDR by contributing DNA repair by HR. Our findings highlight the importance of DDSR1 in maintaining genome stability. Citation Format: Vivek Sharma, Simran Khurana, Nard Kubben, Kotb Abdelmohsen, Philipp Oberdoerffer, Myriam Gorospe, Tom Misteli. A lncRNA regulates DNA repair by homologous recombination. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr PR03.