tbuckley/cabot-search huggingface dataset:
FRI0342 Does exclusion of the ESR from JADAS affect validity in the clinical setting in assessment of new-onset juvenile inflammatory arthritis?:
Authors: F. Mcerlane, M.W. Beresford, E.M. Baildam, S.E. Chieng, J. Davidson, H.E. Foster, J. Gardner-Medwin, M. Lunt, L.R. Wedderburn, K.L. Hyrich, W. Thomson
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Juvenile Arthritis Disease Activity Score (JADAS) is a 4 variable composite disease activity (DAS) score for juvenile idiopathic arthritis (JIA), including active 10, 27 or 71 joint count (AJC), physician global (PGA), parent/child global (PGE) and ESR. We have shown in previous work that the ESR is not routinely assessed in all patients with JIA; this reduces the feasibility of JADAS use in clinical practice. <h3>Objectives</h3> To determine whether exclusion of the ESR from JADAS (labelled JADAS3 followed by 10, 27 or 71 respectively) influences correlation with single markers of disease activity (DA), in a prospective inception cohort of UK children presenting with new onset inflammatory arthritis. <h3>Methods</h3> The JADAS 10, 27 and 71 and JADAS3-10, -27 and -71 were determined for all children in the Childhood Arthritis Prospective Study (CAPS) with complete data available at baseline. Correlation of JADAS 71 and JADAS3-71 with single markers of DA was determined for all ILAR subtypes (Spearman's rank statistic). <h3>Results</h3> 354/1041 (34%) children had all four variables and 562/1041 (54%) children had three variables (ie without ESR) available at baseline. 994 (95%) had AJC available, 811 (78%) PGA, 694 (67%) PGE and 647 (62%) ESR. Median age at disease onset was 6.8 years (IQR 2.8-10.8), median disease duration at diagnosis was 5.2 mths (IQR 2.5-10.9) and 64% were female. Correlation for the whole cohort between JADAS3-71 and both JADAS3-27 and -10 was 0.99. Median JADAS3-71 ranged from 5.9-16.7/91 across the subtypes (Table 1). Correlation of JADAS 71 with JADAS3-71 was high, both for the whole cohort (0.96) and within individual ILAR subtypes (range 0.91 to 0.99). Correlation of JADAS 71 and JADAS3-71 with single markers of DA was similar between subtypes with the exception of the ESR; this may simply be a reflection of the variation in the frequency of measurement of the ESR between subgroups. <h3>Conclusions</h3> Correlation of single DA markers with JADAS3-71 was moderate to good across all ILAR subtypes. JADAS3 is potentially a valid surrogate for JADAS in the clinical setting when the ESR is unavailable. Further validation studies are required to determine whether JADAS and JADAS3 reflect changes in DA over time. <h3>Disclosure of Interest</h3> None Declared
ACS Reports On Cancer and The Poor
Authors: J. Corliss
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article ACS Reports On Cancer and The Poor Get access Julie Corliss Julie Corliss Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 16, 16 August 1989, Pages 1206–1207, https://doi.org/10.1093/jnci/81.16.1206 Published: 16 August 1989
Mucosectomie et Radiofréquence dans le traitement de l'EBO en dysplasie de haut grade
Authors: M Robert, S Godat, F Caillol, A Autret, E Bories, C Pesenti, JP Ratone, F Poizat, M Giovannini
Journal: Endoscopy (2015)

Le traitement endoscopique de première intention des tumeurs superficielles de l'oesophage est la résection endoscopique (RE). Les techniques de thermo-ablation (RFA) se sont associées à la RE. Nous avons voulu analyser l'efficacité de la RFA associée à la RE chez les patients ayant de la dysplasie de haut grade (DHG) sur endobrachyoesophage (EBO).
Human Recombinant DNA–Derived Antihemophilic Factor (Factor VIII) in the Treatment of Hemophilia A
Authors: Richard S. Schwartz, Charles F. Abildgaard, Louis M. Aledort, Steven Arkin, Arthur L. Bloom, Hans H. Brackmann, Doreen B. Brettler, Hiromu Fukui, Margaret W. Hilgartner, Martin J. Inwood, Carol K. Kasper, Peter B.A. Kernoff, Peter H. Levine, Jeanne M. Lusher, Pier M. Mannucci, Inge Scharrer, Mary A. MacKenzie, Nazreen Pancham, Harng S. Kuo, Randy U. Allred
Journal: New England Journal of Medicine (1990)

Current treatment of hemophilia A, a hereditary disorder affecting approximately 1 in 10,000 males, relies on plasma-derived factor VIII concentrates. We tested the safety and efficacy of a recombinant factor VIII preparation for the treatment of this disorder.
Abstract 5426: Severe hypoxia drives the increased glucose demand in ascites carcinomas.
Authors: Xiao-Feng Li
Journal: Cancer Research (2013)

Abstract Warburg reported his discovery in Ehrlich ascites carcinoma model, that in the presence of ample oxygen (21% or 150 mmHg O2), cancer cells utilize glucose by “aerobic glycolysis” (Warburg effect), apparently, ascites carcinoma had been assumed to be oxic. However, during past decade, growing evidences indicated that hypoxic cancer cells had evaluated radiolabeled glucose analog18F-FDG uptake than oxic cancer cell in vitro and in vivo. The objective of this study was to observe the oxygen status of ascites fluid and ascites carcinoma in mouse model of ascites carcinoma and its effect on glucose metabolism. Methods: Ascites carcinoma (floating single cells or clusters) and serosa tumors (attached to serosa) were induced by HT29, A549 or MDA-MB-231 cancer cells in the mouse peritoneal cavity. Ascites pO2 was measured using OxyLite systems in ketamine/xylazene anesthetized mice. Hypoxia status in ascites carcinoma and serosa tumors was tested by immunohistochemical visualization of exogenous hypoxia marker pimonidazole binding and HIF1alpha induced glucose transporter-1 expression. Glucose metabolism of was examine by 18F-FDG autoradiography. Effect of carbogen breathing (95% O2 &amp; 5% CO2) on 18F-FDG uptake was investigated. Results: The pO2 of ascites was measured as low as 0.90mmHg (or 0.5% O2) in mice with HT29 ascites carcinomas. In all cell lines we tested, ascites carcinomas was evident 4-6 wk after cell inoculation, all ascites tumors were stained positive for pimonidazole and glucose transporter-1 (GLUT-1), indicating severe hypoxia. Hypoxia status in serosa tumors was heterogeneous and dependent on tumor size. 18F-FDG uptake was significantly higher in ascites and sub-millimeter serosa tumors than in larger ones (generally greater than 1 mm), the former was stained positive for pimonidazole and GLUT-1, but the latter was not. Carbogen breathing (2hrs) significantly reduced 18F-FDG uptake and pimonidazole binding in ascites carcinoma and submillimeter serosa tumors. GLUT1 expression was not affected. Conclusions: In mouse model of ascites carcinoma, ascites and floating ascites carcinoma are severely hypoxic which is in contradict with ample oxygen condition of Ehrlich ascites carcinoma model where “Warburg effect” derived from. Glucose utilization measured by 18F-FDG uptake is oxygen dependent in both ascites carcinoma and serosa tumors, this is unexplained sole by “aerobic glycolysis” of glucose metabolism, thus challenging Warburg effect theory. This study was supported by Kentucky Lung Cancer Research Program Award Citation Format: Xiao-Feng Li. Severe hypoxia drives the increased glucose demand in ascites carcinomas. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5426. doi:10.1158/1538-7445.AM2013-5426
Abstract P5-10-15: Genetic variants located in beta2 adrenergic receptor gene (ADRB2) and miRNA let-7 binding site alter breast cancer susceptibility: a case control analysis
Authors: Y Du, J Lu
Journal: Cancer Research (2012)

Abstract Previous studies have shown that a potential association may exist between risk of breast cancer and polymorphisms in the beta-adrenergic receptor gene. ADRB2 is a target for miRNA let-7 and it is reported that low let-7 expression probably increases risk of breast cancer. In this study, we investigated the relationship between genetic variants located in alpha2 and beta2 adrenergic receptor genes and miRNA let-7 binding sites with breast cancer risk in benign mammary disease and sporadic breast cancer. We assessed frequency distributions of these variants in 741 patients with histologically confirmed breast cancer and 315 controls with benign mammary disease. We initially demonstrated that rs1042713, located in ADRB2 and rs11292, located in miRNA let-7 binding site were associated with susceptibility to breast cancer. A significant association was observed between GG, AG+GG genotype compared to AA genotype of SNP rs1042713 and a decreased breast cancer risk (adjusted OR = 0.79, 95%CI: 0.64–0.97, p = 0.025; adjusted OR = 0.72, 95%CI: 0.54–0.96, p = 0.028). We also found a significant association between TC, TC+CC genotype compared to TT genotype of SNP rs11292 and an increased breast cancer risk (adjusted OR = 1.44, 95%CI: 1.01–2.06, p = 0.044; adjusted OR = 1.43, 95%CI: 1.01–2.02, p = 0.044). The allele of G of SNP rs1042713 was associated with a decreased risk of breast cancer (OR = 0.79, 95%CI: 0.66–0.96, p = 0.018). Taken together, our study demonstrated that genetic variants located in ADRB2 and miRNA let-7 binding site could alter breast cancer risk. Keywords: ADRB2 gene, miRNA let-7, polymorphism, breast cancer Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-10-15.
Abstract 1538: Role of mitochondrial dysfunction in GPX regulation and glutathione metabolism
Authors: Weiqin Lu, Li Feng, Hui Zhang, Peng Huang
Journal: Cancer Research (2010)

Abstract Many cancer cells exhibit mitochondrial respiratory dysfunction, which is associated with metabolic alterations, change in cellular redox states, and drug resistance. It is also known that elevated glutathione in cancer cells may promote their survival and resistance to anticancer agents. However, the exact relationship between mitochondrial dysfunction and alterations in cell redox states and viability remain elusive, and the underlying regulatory mechanisms are unclear. In this study, we used a dominant negative form of mitochondrial DNA polymerase γ (POLGdn) expressed in a T-Rex293 tet/on system as a model to induce mitochondrial dysfunction, and showed that suppression of mitochondrial respiration caused a significant increase in ROS generation. Mitochondrial dysfunction also led to a significant increase in glutathione, along with an elevated expression of its rate-limiting enzyme GCLC and the upstream transcription factor Nrf-2. Interestingly, the mRNA expression of glutathione peroxidases GPX1 and GPX4 remain the same, while the GPX proteins and enzyme activity were significantly increased in the mitochondrial defective cells. Since GPX1 and GPX4 are selenium-containing enzymes, they require selenocysteine-tRNA for their protein synthesis. We further demonstrated that selenocysteine-tRNA expression and its transcription factor ZNF143 protein were significantly increased after induction of mitochondrial dysfunction. Furthermore, siRNA knockdown of ZNF143 led to a decrease of GPX activity, an increase in ROS, and a reduction in cell viability in the mitochondrial defective cells. Similarly, a knockdown of GPX1 by shRNA in the mitochondrial defective cells also compromised cell survival. We also observed that ZNF143 protein level was decreased in the GPX1-knockdown cells, suggesting that GPX1 has a positive feedback role in regulating ZNF143 expression. These data suggest that mitochondrial dysfunction led to an activation of glutathione synthesis and an increase in GPX activity through upregulation of the transcription factors Nrf-2 and ZNF143, respectively, and that mitochondrial dysfunction in cancer cells seems to set a new balance between the increase in ROS generation and the elevation in glutathione antioxidant system to maintain cell survival. As such, targeted inhibition of selenocysteine-tRNA, selenoenzymes, or glutathione synthesis may be potential therapeutic strategies for cancer treatment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1538.
The Risk of the Hemolytic–Uremic Syndrome after Antibiotic Treatment of<i>Escherichia coli</i>O157:H7 Infections
Authors: Craig S. Wong, Srdjan Jelacic, Rebecca L. Habeeb, Sandra L. Watkins, Phillip I. Tarr
Journal: New England Journal of Medicine (2000)

Children with gastrointestinal infections caused by Escherichia coli O157:H7 are at risk for the hemolytic–uremic syndrome. Whether antibiotics alter this risk is unknown.
AB1085 Infections during rheumatic diseases: A serie of 146 patients
Authors: F. Rahal, R. Chitouane, S. Slimani, S. Lefkir, N. Brahimi, A. Ladjouze-Rezig
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To asses the prevalence of infections in rheumatic diseases and study their risk factors. <h3>Methods</h3> Retrospective study conducted on algerien patients' medical files with inflammatory rheumatic diseases admitted from January, 2009 to June, 2011 in BenAknoun hospital in Algeria. Demographic and clinical data were recorded. A current or past infection was looked for by precising the type of infection, its location, and its gravity. A severe infection was defined as a tuberculous infection or an infection other than tubercular but motivating admission to the hospital. <h3>Results</h3> One hundred and sixty five algerien patients with chronic inflammatory rheumatic diseases were admitted (96 rheumatoid arthritis, 17 systemic erythematosus lupus, 15 systemic sclerodermas, 13 Sjögren's syndrome, 9 JIA, 1 primary Hughes syndrome, 2 Reynolds syndromes, 6 dermatomyositis, 3 mixed connective diseases, 2 Behçet diseases and 1 Still disease. There were 132 women and 33 men, average age 43.1±16.1 years, evolution duration 7.1±6.8 years. All patients were treated with glucocorticoids for more than 3 months and among them, 26,7% received an equivalent of prednisone &gt;10mg/d. Global prevalence of the infectious events was 30,3%, 30,2% for RA and 30,4% for the other diseases. The most frequent locations were lung (24%) and urinary (10%) infections as well as tuberculosis (10%). <h3>Conclusions</h3> Infections in connective tissue diseases are frequent and involve approximately 1/3 the patients, severe infection involves about 10% of the patients. Age is associated with more infectious events; males are associated with severe infections. Lupus is the most associated disease with infections. <h3>References</h3> Zandman-Goddard G and coll.SLE and infections.Clin Rev Allergy Immunol 2003;25(1):29-40 Noel V and coll. Riskfactors and prognostic influence of infections in a monocentrique cohortb of 87 adults with systémic lupus erythematosus. Ann Rheum Dis2001;60: 1141-4 <h3>Disclosure of Interest</h3> None Declared
Pedunculated Giant Liver Hemangioma Mimicking a Hypervascular Gastric Tumor on Tc-99m RBC SPECT
Authors: CHENG-CHIEN TSAI, TZU-CHEN YEN, KAI-YUAN TZEN
Journal: Clinical Nuclear Medicine (1999)

Physical examination revealed an asymptomatic abdominal mass in a 53-year-old woman. Liver ultrasound and a CT scan revealed a huge pedunculated mass, probably from the left hepatic lobe. Tc-99m RBC liver SPECT showed an area of increased blood pool activity that measured 8×8.5×10 cm in the left upper quadrant. At surgery, a cavernous hemangioma, about 10×15 cm in diameter, was seen arising from the left hepatic lobe with protrusion into the lesser sac.
P1020 VOLATILE ORGANIC COMPOUNDS IN EXHALED AIR AS POTENTIAL NON-INVASIVE BIOMARKER FOR LIVER CIRRHOSIS
Authors: K.E. Pijls, A. Smolinska, D.M.A.E. Jonkers, E.J.C. Moonen, J.W. Dallinga, A.A.M. Masclee, G.H. Koek, F.J. van Schooten
Journal: Journal of Hepatology (2014)
LACK OF ASSOCIATION BETWEEN LDL-CHOLESTEROL, PLAQUE BURDEN AND LIPID-RICH PLAQUE IN CORONARY LESIONS REQUIRING PCI: THE COLOR REGISTRY
Authors: Stephen J. Nicholls, Jordan Andrews, Nisha Schwarz, Akiko Maehara, Mitsuaki Matsumura, Myong Hwa Yamamoto, Annapoorna Kini, Brijeshwar Maini, Nabil Dib, Priti Shah, James Muller, Gary Mintz, Gregg Stone, Giora Weisz
Journal: Journal of the American College of Cardiology (2016)
P234 QVA149 once daily improves lung function, dyspnoea and health status independent of prior medications and disease severity: the SHINE study: Abstract P234 Table 1.
Authors: KR Chapman, ED Bateman, N Gallagher, H Hu, D Banerji
Journal: Thorax (2013)

<h3>Introduction</h3> QVA149 is a novel, inhaled, once-daily, fixed-dose combination of the long-acting β<sub>2</sub>-agonist (LABA) indacaterol and the long-acting muscarinic antagonist (LAMA) glycopyrronium (NVA237) in development for the maintenance treatment of chronic obstructive pulmonary disease (COPD). The SHINE study compared the effects of QVA149 110/50 µg, indacaterol 150 µg, glycopyrronium 50 µg, tiotropium 18 µg and placebo in patients with COPD.<sup>1</sup> Here, we present the data on improvements in lung function (forced expiratory volume in 1 second area under the curve [FEV<sub>1 </sub>AUC<sub>5 min-4 h</sub>] and trough FEV<sub>1</sub>), transition dyspnoea index (TDI) and St George’s Respiratory Questionnaire (SGRQ - total score) by prior medication use and COPD disease severity subgroups. <h3>Methods</h3> In this 26-week, multicentre, double-blind, parallel-group, placebo- and active-controlled (open-label tiotropium) study, patients aged ≥40 years with moderate-to-severe COPD (post-bronchodilator FEV<sub>1</sub>/forced vital capacity (FVC) &lt;0.7 and FEV<sub>1</sub> ≥30% to &lt;80% predicted) and a smoking history of ≥10 pack-years were randomised to receive once-daily QVA149, indacaterol, glycopyrronium, tiotropium or placebo (2:2:2:2:1). <h3>Results</h3> Of the 2144 patients (mean age 63.9 years; mean FEV<sub>1</sub> post-bronchodilator 55.2% predicted) who were randomised (QVA149 [<i>n</i> = 475], indacaterol [<i>n</i> = 477], glycopyrronium [<i>n</i> = 475], tiotropium [<i>n</i> = 483] and placebo [<i>n</i> = 234]), 89.1% completed the study. QVA149 showed significant improvements in lung function, dyspnoea and health status compared with placebo in patient subgroups based on prior medication use and COPD disease severity (Table 1). Additionally, FEV<sub>1</sub> AUC<sub>5 min-4 h</sub>was significantly improved for QVA149 versus placebo (p &lt; 0.001) regardless of the prior medication use and disease severity. <h3>Conclusion</h3> With once-daily QVA149, significant improvements were seen in both moderate and severe COPD patients and independent of medications used before recruitment and randomisation into the SHINE study. <h3>Reference</h3> Bateman <i>et al</i>. Dual bronchodilation with QVA149 versus single bronchodilator therapy: the SHINE study. Eur Respir J. 2013 May 30. [Epub ahead of print].
Development of Lithogenic Bile during Puberty in Pima Indians
Authors: Lynn J. Bennion, William C. Knowler, David M. Mott, Alan M. Spagnola, Peter H. Bennett
Journal: New England Journal of Medicine (1979)

To determine whether highly saturated bile is a congenital or acquired characteristic of Pima Indians and to elucidate the basis of the rapid postpubertal increase in gallstones in Pimas, we studied the bile of 66 Pimas nine to 21 years of age. Highly saturated bile is not prevalent among Pimas under the age of 13, but bile saturation increases significantly (P less than 0.05) in both sexes during pubertal growth and development. Bile saturation was 15 per cent higher in females than males. Bile acid pools increased with age in the young men, but not in women. Bile cholesterol saturation correlated with obesity (r = 0.41; P less than 0.001) and urinary estrogen excretion (r = 0.44; P less than 0.001). Highly saturated bile may be present for several years before the onset of cholesterol cholelithiasis.
Abstract 884: Pleiotropic effects on lung cancer of genetic susceptibility variants identified for other malignancies: The multiethnic cohort
Authors: Iona C. Cheng, Christian Caberto, Lynne R. Wilkens, Fredrick R. Schumacher, Laurence N. Kolonel, Brian E. Henderson, Daniel O. Stram, Christopher A. Haiman, Loic Le Marchand
Journal: Cancer Research (2011)

Abstract Genome-wide association studies of cancer have succeeded in identifying over 100 susceptibility loci, including some, such as those found at chromosome 8q24 and CPTM1L-TERT that influence the risk of several malignancies. As part of the Population Architecture using Genomics and Epidemiology (PAGE) Study, we evaluated whether established risk variants for 19 different cancer sites, excluding the lung, impact the risk of lung cancer. A total of 148 risk variants for these 19 malignancies were selected from genome-wide association studies published through May, 2009. These SNPs were genotyped in a lung cancer case-control study (cases, n=696; controls, n=3,225) nested within the Multiethnic Cohort Study, a large prospective study conducted among African Americans, Latinos, Japanese Americans, Native Hawaiians and whites. Unconditional logistic regression was performed to evaluate the association between SNPs and lung cancer risk, adjusting for age, sex, race/ethnicity, smoking status (current, never, former), and pack-years of cigarette smoking. Eleven of the 148 SNPs were associated with lung cancer risk (P&amp;lt;0.05): two acute lymphocytic leukemia SNPs, two breast cancer SNPs, one glioma/testicular cancer SNP, one neuroblastoma SNP, four prostate cancer SNPs, and one thyroid cancer SNP. By chance, seven associations would be expected for the 148 tests (148 × 0.05=7), suggesting robust significant associations among the 11 associated SNPs. The top associations (P&amp;lt;0.01) were observed with three prostate cancer SNPs (rs10090154 at 8q24-region 1, P=0.0008; rs7837688 at 8q24-region 1, P=0.0009; rs4962416 at CTBP2, P=0.003) and one breast cancer SNP (rs2981578 at FGFR2, P=0.0074). Future analyses will include approximately 4,400 additional lung cancer cases and controls from the Women's Health Initiative (WHI), Arthrosclerosis Risk In Communities (ARIC) study, and the Cardiovascular Health Study (CHS) as part of the PAGE initiative. If these genetic risk factors are replicated, they may clarify shared pathways involved in the carcinogenic process. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 884. doi:10.1158/1538-7445.AM2011-884
Use of Whole-body Imaging Using Tc-99m RBC in Patients With Soft-tissue Vascular Lesions
Authors: YUSUKE INOUE, SHINICHI WAKITA, TOHRU OHTAKE, TOSHIYUKI OHKUBO, NAOTO HAYASHI, JUNICHI NISHIKAWA, YASUHITO SASAKI
Journal: Clinical Nuclear Medicine (1996)

We investigated the usefulness of whole-body imaging as an adjunct to spot imaging in soft-tissue vascular lesions, such as hemangiomas and vascular malformations. Spot imaging of the known lesion and whole-body imaging were performed 1-3 hours after the injection of Tc-99m RBC in 42 patients with soft-tissue vascular lesions. Whole-body imaging was considered to be useful in only two patients, who had multiple distant occult lesions in addition to large known lesions. It was suggested that the routine addition of whole-body imaging is not cost effective in patients with soft-tissue vascular lesions, although it may be beneficial for detecting occult lesions in patients with hemangiomas.
Cigarette Taxes and the Federal Budget — Report from the CBO
Authors: James R. Baumgardner, Linda T. Bilheimer, Mark B. Booth, William J. Carrington, Noelia J. Duchovny, Ellen C. Werble
Journal: New England Journal of Medicine (2012)

To assess the likely effects on spending and budget deficits of federal policies promoting a healthier population, the Congressional Budget Office modeled the effects of a hypothetical smoking-reduction policy: a 50-cent increase in the federal excise tax on cigarettes.