tbuckley/cabot-search huggingface dataset:
Downsizing the target: the underwater closure technique
Authors: Gabriele Curcio, Antonino Granata, Dario Ligresti, Mario Traina
Journal: Endoscopy (2015)

A 77-year-old man with a 3-cm slightly elevated, nongranular type, laterally spreading tumor (LST-NG 0-IIa) of the sigmoid colon was referred to our institute for endoscopic resection ([Fig. 1]). Piecemeal underwater endoscopic mucosal resection (UEMR) was carried out with a high definition narrow band endoscope (CF-H190L; Olympus Europa SE, Hamburg, Germany). After UEMR, the margins were ablated using argon plasma coagulation. Histology revealed an adenomatous polyp with high grade dysplasia and free deep resection margins. Because of the patient's need to resume antiplatelet therapy with clopidogrel, prophylactic closure of the resection site was carried out.
Cystic fibrosis drug is not cost effective, says NICE
Authors: Anne Gulland
Journal: BMJ (2016)

A drug that would benefit nearly 3000 patients with cystic fibrosis should not be made available on the NHS, says the National Institute for Health and Care Excellence (NICE) in new guidelines.1

Although the drug lumacaftor-ivacaftor (Orkambi; Vertex Pharmaceuticals, Boston, MA, USA) was shown to reduce hospital admission and the use of antibiotics among people with cystic fibrosis, the short term benefits to lung function were modest and the long term benefits were uncertain, said NICE.

The drug costs £104 000 (€131 000; $147 000) …
First‐line low‐dose morphine is better for the control of moderate cancer pain than weaker opioids
Authors: Mary Kay Barton
Journal: CA A Cancer Journal for Clinicians (2016)

Key Points Initiating pain control therapy with low‐dose morphine provided better and faster pain relief versus weaker opioids among patients with moderate cancer pain. The frequency and severity of opioid‐related side effects were similar between the patients treated with morphine and those receiving the weaker opioid.
Comparison of Duodenal Stent Placement with Surgical Gastrojejunostomy for Palliation in Patients with Duodenal Obstructions Caused by Pancreaticobiliary Malignancies
Authors: I.  Maetani, T.  Tada, T.  Ukita, H.  Inoue, Y.  Sakai, J.  Nagao
Journal: Endoscopy (2004)

Background and Study Aims: Palliative treatment for duodenal stenosis with an enteral stent is effective in enhancing the quality of life of patients with duodenal obstruction. There have been no thorough comparisons of duodenal stent placement with standard surgical gastrojejunostomy. The present study evaluated the outcome of duodenal stent placement and surgical gastrojejunostomy for palliation of duodenal stenosis caused by pancreaticobiliary malignancies. Patients and Methods: Medical records for patients who underwent palliative enteral stenting during the past 9 years were retrospectively reviewed, and the patients’ clinical outcome was compared with that in patients who underwent open surgical gastrojejunostomy during the same period. Patients who underwent prophylactic gastrojejunostomy were excluded from the study. Results: Twenty patients (11 men, nine women; mean age 71.8 years) with pancreaticobiliary malignancy underwent palliative enteral stenting (stent group). Nineteen patients (12 men, seven women; mean age 68.7 years) with pancreaticobiliary malignancies underwent surgical gastrojejunostomy (bypass group). In the stent group, the diagnoses were 12 pancreatic cancers, six gallbladder cancers, one bile duct cancer, and one ampullary cancer. In the bypass group, the diagnoses were 14 pancreatic cancers and five gallbladder cancers. There were no significant differences between the two groups with regard to clinical background. Both procedures were successful. There were no differences between the two groups with regard to the technical or clinical success rates, patient survival, possibility of discharge, need for parenteral nutrition, or incidence of complications. However, the time from the procedure to resumption of food intake was shorter in the stent group than in the bypass group (1 day vs. 9 days; P < 0.0001). Improvement in the performance score after the procedure was observed more frequently in the stent group (65 % vs. 26.3 %; P < 0.05). In terms of the median hospital stay from the time of the procedure to the time of initial discharge home (12 patients vs. nine patients), there was no statistical difference (15 days vs. 30 days) due to the small size of the sample. There was no procedure-related mortality in either group. Conclusions: Palliative stent placement was more beneficial than surgical gastrojejunostomy in enhancing the quality of life of patients with duodenal obstruction due to pancreaticobiliary malignancies.
MicroRNAs and pulmonary hypertension: a tight link
Authors: Leonardo Elia, Gianluigi Condorelli
Journal: Cardiovascular Research (2016)

This editorial refers to ‘miR-223–IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach’ by L. Shi et al. , doi:10.1093/cvr/cvw065. 

Lung vasculopathy is a pathological hallmark of pulmonary hypertension (PH). PH is an often fatal disease, the incidence of which is steadily increasing. Current epidemiologic data indicate a PH prevalence of ∼1% of the global population, which might increase up to 10% in people older than 65 years.1 PH is clinically defined by an average pulmonary artery pressure of ≥25 mm Hg at rest. Pathophysiologically, PH is characterized by an elevation of pulmonary circulation pressure which eventually leads to an increase in the pulmonary arterial pressure, ending in right-sided heart failure2: Dysregulation of all cell types composing the lung vessels induces intimal lesions and vascular remodelling, resulting in an elevated vascular resistance of the lung vessels which triggers right heart dysfunction and heart failure.

In terms of aetiology, PH could be classified into three main categories: idiopathic (IPH), in which the causes are unknown; familial (FPH), in which heterozygous BMPR2 mutations account for ∼75% of the cases; and secondary other risk factors (APH), including vascular diseases, congenital heart disease, or even HIV infection. Available treatments for the disease include endothelin-1 receptor antagonists, phosphodiesterase type 5 inhibitors, and administration of prostacyclins, that work …
RNAi delivery by exosome-mimetic nanovesicles – Implications for targeting c-Myc in cancer
Authors: Taral R. Lunavat, Su Chul Jang, Lisa Nilsson, Hyun Taek Park, Gabriela Repiska, Cecilia Lässer, Jonas A. Nilsson, Yong Song Gho, Jan Lötvall
Journal: Biomaterials (2016)
Significant regional variation in treatment and survival of gastric cancer
Authors: N. G. Coburn, C. Swallow, M. L. Quan, C. Law
Journal: Journal of Clinical Oncology (2005)

4004 Background: Lymph node (LN) status is a major determinant of prognosis and treatment of gastric adenocarcinoma (GC). The 1998 American Joint Commission on Cancer (AJCC) guidelines mandate pathologic examination of 15 LN for accurate staging. We used a large population-based dataset to investigate compliance with these guidelines, and correlated this with overall survival (OS). Methods: We analyzed 11,602 cases of resected GC in the Surveillance, Epidemiology and End Results (SEER) database from 1988–2001. Survival curves were constructed using the Kaplan-Meier method, and relative survival was compared using Cox proportional hazards. Results: In only 27.6% of cases were ≥15 LN examined. From 1988–97, the median number of LN examined was 8; after 1998, it increased to 10 (p<0.001). Factors predictive of adequate LN retrieval were higher stage, higher grade, positive marital status, age 60–74 yrs, later year of diagnosis, non-white race, T2a tumor, more extensive surgery, female sex, and SEER region. Improved OS was predicted by lower stage, lower grade, positive marital status, Asian race, younger age, lower T-stage, distal gastrectomy, female sex, SEER region, and higher number of LN retrieved. There was a strong correlation between OS and adequate LN retrieval (r=0.88). Median and 5 yr OS were the highest in the SEER region with the best LN retrieval, and lowest in the region with the worst rate of adequate LN assessment, 17.5% (p<0.01 for both OS and LN retrieval, see Table). Conclusions: In the majority of patients undergoing resection for GC, LN retrieval remains inadequate despite the 1998 AJCC guidelines. In this population-based analysis, better LN retrieval was associated with improved OS. Significant regional variation in both parameters was observed. Education of both surgeons and pathologists is required to improve LN assessment. More accurate staging will improve prognostication, and facilitate appropriate referral for adjuvant therapy. No significant financial relationships to disclose.
Some Recent Findings Concerning Hepatomas Induced with &lt;italic&gt;p&lt;/italic&gt;-Dimethylaminoazobenzene&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;
Authors: R. Kinosita
Journal: JNCI Journal of the National Cancer Institute (1955)

Some Recent Findings Concerning Hepatomas Induced with p-Dimethylaminoazobenzene R. Kinosita R. Kinosita Department of Cytology, City of Hope Medical Center, and Departments of Infectious Diseases and Pathology, University of California at Los Angeles, Los Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue Supplement_5, April 1955, Pages 1443–1445, https://doi.org/10.1093/jnci/15.Supplement_5.1443 Published: 01 April 1955
Outbreak of measles among adolescents, Belgium, 1996
Authors: K De Schrijver
Journal: Eurosurveillance (1996)

Measles was very common in Belgium before 1985, affecting 95% of children before they reached the age of 15 years. In 1984 the incidence of measles, calculated using data from a general practitioner surveillance system, was 823/100 000 inhabitants (2). Wi
The value of ProMED-mail for the Early Warning Committee in the Netherlands: more specific approach recommended
Authors: M E Zeldenrust, J C Rahamat-Langendoen, M J Postma, J A van Vliet
Journal: Eurosurveillance (2008)

This article describes a retrospective and descriptive study into the added value of ProMED-mail--the global electronic reporting system for outbreaks of emerging infectious diseases and toxins maintained by the International Society for Infectious Diseases--as an early warning system for The Netherlands Early Warning Committee (NEWC). Information about infectious disease events in foreign countries originating from ProMED-mail was retrieved from the reports of the NEWC between May 2006 and June 2007. Each event was analysed in depth in order to determine if it could have been a possible threat to public health in The Netherlands. It was determined whether these events were mentioned in other sources of information used by the NEWC besides ProMED-mail. In addition, we assessed the possible consequences of missing an event when not reading ProMED-mail or of being informed of the event with a time delay. Semi-structured interviews with stakeholders were conducted to explore other functions of ProMED-mail besides early warning. Five out of 25 events reported in ProMED-mail were assessed as a potential threat to The Netherlands, mainly because of the known vulnerability of The Netherlands for vaccine preventable diseases: an outbreak of measles in the United Kingdom and Japan, a case of poliomyelitis in Kenya, and two events concerning Highly Pathogenic Avian Influenza (HPAI) H5N1. The outbreak of measles in Japan and one case of HPAI H5N1 infection in a bird in Germany were only reported by ProMED-mail; the other potential threats were mentioned in other sources with a time delay. ProMED-mail has a limited but real added value over other sources in the early warning of threats. A more specific approach of using ProMED-mail by defining vulnerabilities of a country would be useful and efficient. ProMED-mail is appreciated for providing background and preliminary outbreak information.
Government’s move to cut red tape is impeding public health measures, say charities
Authors: Ingrid Torjesen
Journal: BMJ (2015)

A government policy designed to reduce the regulatory burden on business is making it increasingly difficult to introduce measures to improve public health in the United Kingdom, such as steering people away from unhealthy foods, a group of medical bodies and charities has warned.

To try to remove and simplify the regulations with which businesses must comply, the last coalition government introduced a “one in, one out” rule in 2010. This required government departments to assess the net cost to businesses of complying with any proposed regulation and to identify measures to relieve businesses of regulation to the same net cost. Proposed new regulations and corresponding deregulations then had to be approved by the Cabinet’s Reducing Regulation Subcommittee before being implemented.1

In 2012 the rule was toughened to “one in, two out,” meaning that departments had to identify regulations for removal that had twice the cost burden on business than any regulation they intended to introduce, effectively making it more difficult to introduce new regulations.

For example, before legislation passed in March to …
Choroidal Metastases
Authors: Corey Cutler, Evangelos S. Gragoudas
Journal: Journal of Clinical Oncology (1999)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1999.17.10.3358 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10506639 Choroidal Metastases Corey CutlerxCorey CutlerSearch for articles by this author , Evangelos S. GragoudasxEvangelos S. GragoudasSearch for articles by this author Show More Dana-Farber Cancer Institute, Brigham & Women's Hospital, Harvard Medical School, and Massachusetts Eye & Ear Infirmary, Massachusetts General Hospital, Boston, MA https://doi.org/10.1200/JCO.1999.17.10.3358 First Page Full Text PDF Figures and Tables © 1999 by American Society of Clinical Oncology
Islet Weight Studies in Rats Treated with Tolbutamide
Authors: J K DAVIDSON, R E HAIST
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Supreme Court looks at psychiatry
Authors: P S Appelbaum
Journal: American Journal of Psychiatry (1984)

An analysis of the attitudes of the U.S. Supreme Court toward psychiatry, as expressed in the Court's major opinions on mental health law from 1975 to 1983, reveals significant discrepancies from case to case. The explanation for these puzzling shifts in attitude lies outside the realm of mental health law, in the justices ' aversion to judicial involvement in professional decision making. A close examination of the cases demonstrates the Court's willingness to alter its rhetoric about psychiatry to support this overriding end. Psychiatrists' understanding of the Court and advocacy for their own and their patients' interests must take this broader issue into account.
Case 13-1966
Authors: Walter F. Lever, Wallace H. Clark
Journal: New England Journal of Medicine (1966)

Presentation of CaseA thirty-six-year-old fish cutter was admitted to the hospital because of ulcers on the right leg and right forearm.He had been well until ten months previously, when he scraped his right leg on fish crates and was admitted to another hospital for treatment of "fish poisoning," which responded to penicillin therapy except for the development of "lumps" on the right leg. Four months later "lumps" also appeared on the arms and left leg. The lesions began as blisters and subsequently ulcerated. He became hoarse, lost 14 pounds in weight and stopped work because of generalized weakness. . . .
Rad51C-ATXN7 fusion gene expression in colorectal tumors
Authors: Arjun Kalvala, Li Gao, Brittany Aguila, Kathleen Dotts, Mohammad Rahman, Serge P. Nana-Sinkam, Xiaoping Zhou, Qi-En Wang, Joseph Amann, Gregory A. Otterson, Miguel A. Villalona-Calero, Wenrui Duan
Journal: Molecular Cancer (2016)

Fusion proteins have unique oncogenic properties and their identification can be useful either as diagnostic or therapeutic targets. Next generation sequencing data have previously shown a fusion gene formed between Rad51C and ATXN7 genes in the MCF7 breast cancer cell line. However, the existence of this fusion gene in colorectal patient tumor tissues is largely still unknown. We evaluated for the presence of Rad51C-ATXN7 fusion gene in colorectal tumors and cells by RT-PCR, PCR, Topo TA cloning, Real time PCR, immunoprecipitation and immunoblotting techniques. We identified two forms of fusion mRNAs between Rad51C and ATXN7 in the colorectal tumors, including a Variant 1 (fusion transcript between Rad51C exons 1–7 and ATXN7 exons 6–13), and a Variant 2 (between Rad51C exons 1–6 and ATXN7 exons 6–13). In silico analysis showed that the Variant 1 produces a truncated protein, whereas the Variant 2 was predicted to produce a fusion protein with molecular weight of 110 KDa. Immunoprecipitation and Western blot analysis further showed a 110 KDa protein in colorectal tumors. 5-Azacytidine treatment of LS-174 T cells caused a 3.51-fold increase in expression of the fusion gene (Variant 2) as compared to no treatment controls evaluated by real time PCR. In conclusion we found a fusion gene between DNA repair gene Rad51C and neuro-cerebral ataxia Ataxin-7 gene in colorectal tumors. The in-frame fusion transcript of Variant 2 results in a fusion protein with molecular weight of 110 KDa. In addition, we found that expression of fusion gene is associated with functional impairment of Fanconi Anemia (FA) DNA repair pathway in colorectal tumors. The expression of Rad51C-ATXN7 in tumors warrants further investigation, as it suggests the potential of the fusion gene in treatment and predictive value in colorectal cancers.
Enzymatic Desamination and Dephosphorylation of Ribosenucleic and Desoxyribosenucleic Acids
Authors: Jesse P. Greenstein, Charles E. Carter, Harold W. Chalkley, Florence M. Leuthardt
Journal: JNCI Journal of the National Cancer Institute (1946)

Enzymatic Desamination and Dephosphorylation of Ribosenucleic and Desoxyribosenucleic Acids Get access Jesse P. Greenstein, Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles E. Carter, Charles E. Carter assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold W. Chalkley, Harold W. Chalkley senior physiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Florence M. Leuthardt Florence M. Leuthardt junior biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 1, August 1946, Pages 9–27, https://doi.org/10.1093/jnci/7.1.9 Published: 01 August 1946
Predictive value of lymphography for sites of subdiaphragmatic disease encountered at staging laparotomy in newly diagnosed Hodgkin's disease and non-Hodgkin's lymphoma.
Authors: R A Castellino, N R Dunnick, D R Goffinet, S R Rosenberg, H S Kaplan
Journal: Journal of Clinical Oncology (1983)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1983.1.9.532 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 6668514 Predictive value of lymphography for sites of subdiaphragmatic disease encountered at staging laparotomy in newly diagnosed Hodgkin's disease and non-Hodgkin's lymphoma. R A CastellinoxR A CastellinoSearch for articles by this author , N R DunnickxN R DunnickSearch for articles by this author , D R GoffinetxD R GoffinetSearch for articles by this author , S R RosenbergxS R RosenbergSearch for articles by this author , H S KaplanxH S KaplanSearch for articles by this author https://doi.org/10.1200/JCO.1983.1.9.532 First Page PDF © 1983 by American Society of Clinical Oncology
Levamisole as adjuvant therapy for melanoma: quo vadis?
Authors: D R Parkinson
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.5.716 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2016613 Levamisole as adjuvant therapy for melanoma: quo vadis? D R ParkinsonxD R ParkinsonSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.5.716 PDF "Levamisole as adjuvant therapy for melanoma: quo vadis?." Journal of Clinical Oncology, 9(5), pp. 716–717© 1991 by American Society of Clinical Oncology
18F-FDG PET/CT Imaging of Burkitt Lymphoma Presenting With Unusual Muscle Involvement
Authors: Burcu Dirlik Serim, Tuba Gurleyen Eren, Fulya Oz Puyan, Gülay Durmus Altun
Journal: Clinical Nuclear Medicine (2016)

Extranodal involvement is more common with Burkitt lymphoma (BL) than other subtypes of non-Hodgkin lymphoma in childhood. According to our knowledge, there are rare cases in the literature about muscle involvement of BL, and its 18F-FDG PET/CT findings were not well defined. We report a 6-year-old girl with a histopathologic diagnosis of BL and referred for staging with PET/CT. FDG-avid abdominal lymph nodes and diffuse involvements of right quadriceps muscle were demonstrated.
Corrigendum to “A novel and validated prognostic index in hepatocellular carcinoma: The Inflammation Based Index (IBI)”
Authors: David J. Pinato, Justin Stebbing, Mitsuru Ishizuka, Shahid A. Khan, Harpreet S. Wasan, Bernard V. North, Keiichi Kubota, Rohini Sharma
Journal: Journal of Hepatology (2016)