tbuckley/cabot-search huggingface dataset:
NLRP3 Inflammasome Mediates Aldosterone-Induced Vascular Damage
Authors: Thiago Bruder-Nascimento, Nathanne S. Ferreira, Camila Z. Zanotto, Fernanda Ramalho, Isabela O. Pequeno, Vania C. Olivon, Karla B. Neves, Rheure Alves-Lopes, Eduardo Campos, Carlos Alberto A. Silva, Rubens Fazan, Daniela Carlos, Fabiola L. Mestriner, Douglas Prado, Felipe V. Pereira, Tarcio Braga, Joao Paulo M. Luiz, Stefany B. Cau, Paula C. Elias, Ayrton C. Moreira, Niels O. Câmara, Dario S. Zamboni, Jose Carlos Alves-Filho, Rita C. Tostes
Journal: Circulation (2016)

Inflammation is a key feature of aldosterone-induced vascular damage and dysfunction, but molecular mechanisms by which aldosterone triggers inflammation remain unclear. The NLRP3 inflammasome is a pivotal immune sensor that recognizes endogenous danger signals triggering sterile inflammation.We analyzed vascular function and inflammatory profile of wild-type (WT), NLRP3 knockout (NLRP3-/-), caspase-1 knockout (Casp-1-/-), and interleukin-1 receptor knockout (IL-1R-/-) mice treated with vehicle or aldosterone (600 µg·kg-1·d-1 for 14 days through osmotic mini-pump) while receiving 1% saline to drink.Here, we show that NLRP3 inflammasome plays a central role in aldosterone-induced vascular dysfunction. Long-term infusion of aldosterone in mice resulted in elevation of plasma interleukin-1β levels and vascular abnormalities. Mice lacking the IL-1R or the inflammasome components NLRP3 and caspase-1 were protected from aldosterone-induced vascular damage. In vitro, aldosterone stimulated NLRP3-dependent interleukin-1β secretion by bone marrow-derived macrophages by activating nuclear factor-κB signaling and reactive oxygen species generation. Moreover, chimeric mice reconstituted with NLRP3-deficient hematopoietic cells showed that NLRP3 in immune cells mediates aldosterone-induced vascular damage. In addition, aldosterone increased the expression of NLRP3, active caspase-1, and mature interleukin-1β in human peripheral blood mononuclear cells. Hypertensive patients with hyperaldosteronism or normal levels of aldosterone exhibited increased activity of NLRP3 inflammasome, suggesting that the effect of hyperaldosteronism on the inflammasome may be mediated through high blood pressure.Together, these data demonstrate that NLRP3 inflammasome, through activation of IL-1R, is critically involved in the deleterious vascular effects of aldosterone, placing NLRP3 as a potential target for therapeutic interventions in conditions with high aldosterone levels.
Host Genomic Variants and Risk of Infections During Induction Treatment in Childhood Acute Lymphoblastic Leukemia
Authors: Bendik Lund, Agata Wesolowska, Birgitte Lausen, Louise Borst, Kirsten Kørup Rasmussen, Klaus Muller, Helge Klungland, Ramneek Gupta, Kjeld Schmiegelow
Journal: Blood (2012)
Increased Bone Marrow Plasma Cells at Diagnosis Predicts Overall Mortality in AL Amyloidosis Patients Undergoing Risk-Adapted Stem Cell Transplant
Authors: Chrystal A. Landry, Melody Smith, Joanne F. Chou, Sean M. Devlin, Hani Hassoun, Christina Bello, Ola Landgren, Sergio Giralt, Raymond L. Comenzo, Heather Landau
Journal: Blood (2014)
Liquisolid technique and its applications in pharmaceutics
Authors: Mei Lu, Haonan Xing, Jingzheng Jiang, Xiao Chen, Tianzhi Yang, Dongkai Wang, Pingtian Ding
Journal: Asian Journal of Pharmaceutical Sciences (2016)

Most of the newly developed drug candidates are lipophilic and poorly water-soluble. Enhancing the dissolution and bioavailability of these drugs is a major challenge for the pharmaceutical industry. Liquisolid technique, which is based on the conversion of the drug in liquid state into an apparently dry, non-adherent, free flowing and compressible powder, is a novel and advanced approach to tackle the issue. The objective of this article is to present an overview of liquisolid technique and summarize the progress of its applications in pharmaceutics. Low cost, simple processing and great potentials in industrial production are main advantages of this approach. In addition to the enhancement of dissolution rate of poorly water-soluble drugs, this technique is also a fairly new technique to effectively retard drug release. Furthermore, liquisolid technique has been investigated as a tool to minimize the effect of pH variation on drug release and as a promising alternative to conventional coating for the improvement of drug photostability in solid dosage forms. Overall, liquisolid technique is a newly developed and promising tool for enhancing drug dissolution and sustaining drug release, and its potential applications in pharmaceutics are still being broadened.
Feasibility and Activity Of Bortezomib-Based Therapy In Patients With Relapsed/Refractory Multiple Myeloma Previously Treated With Carfilzomib
Authors: Arti Alagappan, Rupin A Shah, Sheeba K. Thomas, Donna M. Weber, Michael Wang, Raymond Alexanian, Robert Z. Orlowski, Jatin J. Shah
Journal: Blood (2013)
Albumin Is a Prognostic Factor for Response and Overall Survival in Relapsed or Refractory Acute Myeloid Leukemia (AML).
Authors: Rami S. Komrokji, Mohamed A Kharfan-Dabaja, Samantha L Price, Gene A Wetzstein, Alan F List, Hugo F. Fernandez, Timothy J. George, Javier Pinilla-Ibarz, Viet Q. Ho, Jeffrey E Lancet
Journal: Blood (2009)
Total and cause-specific mortality before and after the onset of the Greek economic crisis: an interrupted time-series analysis
Authors: Ioannis Laliotis, John P A Ioannidis, Charitini Stavropoulou
Journal: The Lancet Public Health (2016)

BackgroundGreece was one of the countries hit the hardest by the 2008 financial crisis in Europe. Yet, evidence on the effect of the crisis on total and cause-specific mortality remains unclear. We explored whether the economic crisis affected the trend of overall and cause-specific mortality rates.MethodsWe used regional panel data from the Hellenic Statistical Authority to assess mortality trends by age, sex, region, and cause in Greece between January, 2001, and December, 2013. We used Eurostat data to calculate monthly age-standardised mortality rates per 100 000 inhabitants for each region. Data were divided into two subperiods: before the crisis (January, 2001, to August, 2008) and after the onset of the crisis (September, 2008, to December, 2013). We tested for changes in the slope of mortality by doing an interrupted time-series analysis.FindingsOverall mortality continued to decline after the onset of the financial crisis (−0·065, 95% CI −0·080 to −0·049), but at a slower pace than before the crisis (−0·13, −0·15 to −0·10; trend difference 0·062, 95% CI 0·041 to 0·083; p<0·0001). The trend difference was more evident for females (0·087, 95% CI 0·064–0·11; p<0·0001) than for males (0·040, 0·013–0·066; p=0·007). Those aged at least 75 years experienced more negative effects (trend difference 0·056, 95% CI 0·042 to 0·071; p<0·0001) than did those aged 20–34 years, in whom mortality trends improved (−0·0074, −0·0089 to −0·0059; p<0·0001). Deaths by diseases of the circulatory system declined more slowly after the onset of compared with before the crisis (trend difference 0·043, 95% CI 0·024 to 0·063; p<0·0001), whereas deaths from vehicular accidents declined faster (−0·0062, −0·0090 to −0·0033; p<0·0001), most prominently among men aged 20–34 years (−0·0065, −0·0085 to −0·0044; p<0·0001). Conversely, deaths from suicides (trend difference 0·0021, 95% CI 0·00092–0·0033; p=0·002), diseases of the nervous system (0·0036, 0·0016–0·0056; p=0·002), and mental health problems (0·00073, 0·000047–0·0014 p=0·038) increased after the onset of the crisis. Also, deaths due to adverse events during medical treatment increased significantly after the onset of the crisis (trend difference 0·0020, 95% CI 0·0012–0·0028; p<0·0001). By comparing the expected values of the period after the onset of the crisis with extrapolated values based on the period before the crisis, we estimate that an extra 242 deaths per month occurred after the onset of the crisis.InterpretationMortality trends have been interrupted after the onset of compared with before the crisis, but changes vary by age, sex, and cause of death. The increase in deaths due to adverse events during medical treatment might reflect the effects of deterioration in quality of care during economic recessions.FundingNone.
68Ga-PSMA Expression in Pseudoangiomatous Stromal Hyperplasia of the Breast
Authors: Dharmender Malik, Rajender K. Basher, Bhagwant Rai Mittal, Tarun Kumar Jain, Amanjit Bal, Shrawan Kumar Singh
Journal: Clinical Nuclear Medicine (2016)

Ga-labeled prostate-specific membrane antigen ligand PET-CT has emerged as a promising technique to evaluate the extent of disease in patients with prostate carcinoma. We are reporting a 63-year-old man with prostatic carcinoma subjected to Ga-prostate-specific membrane antigen ligand PET-CT for initial staging. In addition to the radiotracer uptake in known primary site (prostate), focal increased radiotracer uptake was also noticed in the left breast. Subsequent biopsy of the breast lesion revealed PASH (pseudoangiomatous stromal hyperplasia), which is a benign mesenchymal proliferative lesion that may present clinically as palpable mass requiring further evaluation to rule out malignancy.
Loss of the transforming growth factor‐β effector β2‐Spectrin promotes genomic instability
Authors: Jian Chen, Vivek Shukla, Patrizia Farci, Jaclyn Andricovich, Wilma Jogunoori, Lawrence N. Kwong, Lior H. Katz, Kirti Shetty, Asif Rashid, Xiaoping Su, Jon White, Lei Li, Alan Yaoqi Wang, Boris Blechacz, Gottumukkala S. Raju, Marta Davila, Bao‐Ngoc Nguyen, John R. Stroehlein, Junjie Chen, Sang Soo Kim, Heather Levin, Keigo Machida, Hidekazu Tsukamoto, Peter Michaely, Alexandros Tzatsos, Bibhuti Mishra, Richard Amdur, Lopa Mishra
Journal: Hepatology (2016)

Exposure to genotoxins such as ethanol‐derived acetaldehyde leads to DNA damage and liver injury and promotes the development of cancer. We report here a major role for the transforming growth factor β/mothers against decapentaplegic homolog 3 adaptor β2‐Spectrin (β2SP, gene Sptbn1 ) in maintaining genomic stability following alcohol‐induced DNA damage. β2SP supports DNA repair through β2SP‐dependent activation of Fanconi anemia complementation group D2 (Fancd2), a core component of the Fanconi anemia complex. Loss of β2SP leads to decreased Fancd2 levels and sensitizes β2SP mutants to DNA damage by ethanol treatment, leading to phenotypes that closely resemble those observed in animals lacking both aldehyde dehydrogenase 2 and Fancd2 and resemble human fetal alcohol syndrome. Sptbn1 ‐deficient cells are hypersensitive to DNA crosslinking agents and have defective DNA double‐strand break repair that is rescued by ectopic Fancd2 expression. Moreover, Fancd2 transcription in response to DNA damage/transforming growth factor β stimulation is regulated by the β2SP/mothers against decapentaplegic homolog 3 complex. Conclusion : Dysfunctional transforming growth factor β/β2SP signaling impacts the processing of genotoxic metabolites by altering the Fanconi anemia DNA repair pathway. (H epatology 2017;65:678‐693)
Nucleotide Insertions and Deletions in Chronic Lymphocytic Leukemia. A CLL Specific Deletion among IGHV3-21 Expressing Cases with Stereotyped Receptors.
Authors: Chrysoula Belessi, Frédéric Davi, Kostas Stamatopoulos, Massimo Degano, Thanassis Andreou, Carol Moreno, Hélène Merle-Beral, Marta Crespo, Nikolaos Laoutaris, Emili Montserrat, Federico Caligaris-Cappio, Achilles Anagnostopoulos, Paolo Ghia
Journal: Blood (2005)
Final Analysis of a Phase 2 Study of Lenalidomide and Rituximab in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Authors: Xavier C Badoux, Michael J Keating, Susan O'Brien, William G. Wierda, Stefan Faderl, Zeev Estrov, Manolo Pasia, Susan Lerner, Rachel L Sargent, Hagop M. Kantarjian, Alessandra Ferrajoli
Journal: Blood (2011)
Addition of Rituximab to Front-Line-Treatment Highly Improved the Outcome of Elderly Patients with Follicular Lymphoma: a Population Based-Study From the Modena Cancer Registry
Authors: Stefano Luminari, Irene Biasoli, Luigi Marcheselli, Monica Bellei, Alessandra Dondi, Sonia Mastronardi, Marina Cesaretti, Massimo Federico
Journal: Blood (2012)
Niche-Dependent Growth of Malignant and Pre-Neoplastic Plasma Cells in Humanized Mice
Authors: Rituparna Das, Till Strowig, Rakesh Verma, Srinivas Koduru, Anja Hafemann, Stephanie Hopf, Mehmet H. Kocoglu, Chiara Borsotti, Lin Zhang, Andrew R Branagan, Elizabeth Eynon, Markus Manz, Richard Flavell, Madhav V Dhodapkar
Journal: Blood (2015)
Challenges in Oncology
Authors: Muffaddal Morkas, Donald Fleming, Michael Hahl
Journal: Journal of Clinical Oncology (2002)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.3.867 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11821473 Challenges in Oncology Case 2. Radiation Recall Associated With Docetaxel Muffaddal MorkasxMuffaddal MorkasSearch for articles by this author , Donald FlemingxDonald FlemingSearch for articles by this author , Michael HahlxMichael HahlSearch for articles by this author Show More James Graham Brown Cancer Center, University of Louisville, Louisville, KY https://doi.org/10.1200/JCO.2002.20.3.867 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
New sensor technologies in quality evaluation of Chinese materia medica: 2010–2015
Authors: Xiaosu Miao, Qingyu Cui, Honghui Wu, Yanjiang Qiao, Yanfei Zheng, Zhisheng Wu
Journal: Acta Pharmaceutica Sinica B (2016)

New sensor technologies play an important role in quality evaluation of Chinese materia medica (CMM) and include near-infrared spectroscopy, chemical imaging, electronic nose and electronic tongue. This review on quality evaluation of CMM and the application of the new sensors in this assessment is based on studies from 2010 to 2015, with prospects and opportunities for future research.
Autologous Hematopoietic Cell Transplantation In Multiple Myeloma Patients Age 70 Years and Older.
Authors: Qaiser Bashir, Wei Wei, Alexandre Chiattone, Gabriela Rondon, Simrit Parmar, Nina Shah, Ernesto Harold Booc, Dinh Yvonne, Qureshi Sofia, Jatin J Shah, Robert Z. Orlowski, Donna Weber, Richard Champlin, Sergio Giralt, Muzaffar H. Qazilbash
Journal: Blood (2010)
TRUNK MUSCLE ACTIVATION IN FREE BARBELL AND SUPPORT MACHINE SQUAT AT THE SAME RELATIVE LOADS
Authors: DR Clark, MI Lambert, AM Hunter
Journal: British Journal of Sports Medicine (2016)

Measurement of trunk muscle activation (TMA) using surface electromyography (sEMG) in BS is novel and has focussed on squats on unstable surfaces. The hack squat (HS) has more support than BS and is performed at greater absolute loads but lower trunk muscle activation. This has implications for the application of both exercises in exercise training programmes. The purpose of this study was to compare 1RM and TMA in BS and HS at 4 relative loads, 65, 75, 85 and 95% of system mass max (SM). Ten males completed three test sessions: 1) BS and HS 1RM; 2) TMA test familiarization, and; 3) TMA for 3 reps at 4 loads for BS and HS. Kinematics measured by linear transducer and sEMG for rectus abdominus (RA), external oblique (EO), upper lumbar erector spinae (ULES) and lumbar sacral erector spinae (LSES). Vastus lateralis (VL) sEMG reference lower limb muscle activation. sEMG amplitude determined by root mean square (RMS) processing. Mean RMS for each phase of BS and HS at 75, 85 and 95% SM were normalized to mean concentric (con) BS RMS at 65% SM (Balshaw &amp; Hunter, JEK 2012,22,308–319). Mean HS 1RM was 18.2% greater than BS, hence 4 test loads in HS were significantly (p&lt;0.01) higher than BS. Eccentric (ecc) bar displacement was significantly (p&lt;0.001) less in HS than BS for 4 loads. Duration of ecc phase was shorter (p&lt;0.001) in BS than HS. Duration increased (p&lt;0.01) in both phases and exercises with load. BS TMA was greater than HS for all muscles, phases and loads. This was significant (p&lt;0.05) in 14/24 instances (3 loads x 4 muscles x 2 phases). TMA increased significantly (p&lt;0.05) with load in all muscles for both exercises and phases apart from HS LSES in ecc phase. VL RMS was greater in BS than HS for all loads but only significant (p&lt;0.05) in con phase. Despite higher absolute test loads and force in HS, TMA was higher in BS. BS is an effective method of developing trunk strength and TMA is sensitive to load in both BS and HS.
Evaluation of a Web-Based Cognitive Rehabilitation Program in Cancer Survivors Reporting Cognitive Symptoms After Chemotherapy
Authors: Victoria J. Bray, Haryana M. Dhillon, Melanie L. Bell, Michael Kabourakis, Mallorie H. Fiero, Desmond Yip, Frances Boyle, Melanie A. Price, Janette L. Vardy
Journal: Journal of Clinical Oncology (2017)

Purpose Cognitive impairment is reported frequently by cancer survivors. There are no proven treatments. We evaluated a cognitive rehabilitation program (Insight) and compared it with standard care in cancer survivors self-reporting cognitive symptoms. Patients and Methods We recruited adult cancer survivors with a primary malignancy (excluding central nervous system malignancies) who had completed three or more cycles of adjuvant chemotherapy in the previous 6 to 60 months and reported persistent cognitive symptoms. All participants received a 30-minute telephone consultation and were then randomly assigned to the 15-week, home-based intervention or to standard care. Primary outcome was self-reported cognitive function (Functional Assessment of Cancer Therapy Cognitive Function [FACT-COG] perceived cognitive impairment [PCI] subscale): difference between groups after intervention (T2) and 6 months later (T3). Results A total of 242 participants were randomly assigned: median age, 53 years; 95% female. The primary outcome of difference in FACT-COG PCI was significant, with less PCI in the intervention group at T2 ( P &lt; .001). This difference was sustained at T3 ( P &lt; .001). At T2, there was a significant difference in all FACT-COG subscales, favoring the intervention. Neuropsychological results were not significantly different between the groups at T2 or T3. There were significantly lower levels of anxiety/depression and fatigue in the intervention group at T2. There were significant improvements in stress in the intervention group at both time points. There was no significant difference in quality of life between the groups at T2, but the intervention group had better quality of life at T3. Conclusion The intervention, Insight, led to improvements in cognitive symptoms compared with standard care. To our knowledge, this is the first large randomized controlled trial showing an improvement in self-reported cognitive function in cancer survivors, indicating that this intervention is a feasible treatment.
Re-Induction Therapy Decisions Based on Day 14 Bone Marrow Biopsy in Acute Myeloid Leukemia,
Authors: Tod A. Morris, David A. Rizzieri, Carlos M de Castro, Louis F. Diehl, Jon P. Gockerman, Anand S. Lagoo, Joseph O. Moore, Arati V Rao
Journal: Blood (2011)
Effect of Graft Source on Alternative Unrelated Donor Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation in Adults with Acute Myeloid Leukaemia after: A Study from the SFGM-TC
Authors: Florent Malard, Noel Milpied, Didier Blaise, Patrice Chevallier, Mauricette Michallet, Bruno Lioure, Laurence Clement, Nathalie Fegueux, Catherine Cordonnier, Régis Peffault de Latour, Mohamad Mohty
Journal: Blood (2014)
High Dose Cytarabine and Clofarabine (HiDAC → CLOF) in Relapsed or Refractory Acute Myeloid Leukemia, a Phase 2 Trial.
Authors: Bayard Powell, Ralph D’Agostino, Denise Levitan, Leslie Renee Ellis, Susan Lyerly, Megan Skiles, Megan Manuel, Robin Harrelson, Claire Kimbrough, David Duane Hurd
Journal: Blood (2008)
THE DEVELOPMENT AND VALIDATION OF A RUGBY LEAGUE MATCH SIMULATION – INTERCHANGE PROTOCOL WITH COLLISION ELEMENTS
Authors: P Williamson, M Weston
Journal: British Journal of Sports Medicine (2016)

Rugby league is a collision sport that is intermittent in nature. Players require highly developed maximal aerobic power, muscular strength and power and speed and agility, to perform through an eighty minute game. In contrast to starting players, interchange players often perform 2 short (∼20 minutes) and more intense play. The aim of the investigation was to further develop a rugby league match simulation protocol for interchange players and determine the external validity and test – retest reliability among semi-professional rugby league players. Our modified Rugby League Movement Simulation Protocol for Interchange players included more realistic contact elements during the ‘Ball in Play’ portion of testing. Eight semi-professional Championship Rugby League players (age=26±3 years, height=180±3.4 cm, body mass=102.3±11.5 kg) performed the RLMSP-i twice, separated by one week. The protocol involved walking, jogging, running, sprinting and contact elements, based upon GPS data recorded during Super League matches. Movement was recorded using 5 Hz GPS device and heart rate (HR) was recorded by HR monitor and later calculated as a percentage of each participant's age-predicted maximum. Based on previous research, the threshold for smallest worthwhile change (SWC) was 0.2 SDs. The coefficient of variation (CV±95% CL) of the RLMSP-i for Heart Rate Peak (SWC=2.54) was 0.5 (±0.7), RPE (SWC=0.22) 4.5 (±6.6), peak speed (SWC=0.31) 8.6 (±11.0), distance (SWC=1.58) 15.6 (±16.0), and ≥HIT running m/min (SWC=0.47) 23 (±20). In only one case (Heart Rate Peak) case was the CV smaller than the smallest worthwhile change, whilst in only Heart Rate Peak was very large change (10 x SWC) larger than the CV observed. These data suggest that our modified protocol produces comparable responses in heart rate and ≥HIT m/min as observed during Super League match performances, but lower values of total m/min and peak speed. Due to the presence of an enhanced contact element, contributing to the overall physiological load of the participant, it provides a reliable measure of physical performance for Heart Rate Peak, Heart Rate and ratings of perceived exertion, but not for distance, ≥HIT m/min or peak speed.
Methodological Standards and Patient-Centeredness in Comparative Effectiveness Research
Journal: JAMA (2012)

Rigorous methodological standards help to ensure that medical research produces information that is valid and generalizable, and are essential in patient-centered outcomes research (PCOR). Patient-centeredness refers to the extent to which the preferences, decision-making needs, and characteristics of patients are addressed, and is the key characteristic differentiating PCOR from comparative effectiveness research. The Patient Protection and Affordable Care Act signed into law in 2010 created the Patient-Centered Outcomes Research Institute (PCORI), which includes an independent, federally appointed Methodology Committee. The Methodology Committee is charged to develop methodological standards for PCOR. The 4 general areas identified by the committee in which standards will be developed are (1) prioritizing research questions, (2) using appropriate study designs and analyses, (3) incorporating patient perspectives throughout the research continuum, and (4) fostering efficient dissemination and implementation of results. A Congressionally mandated PCORI methodology report (to be issued in its first iteration in May 2012) will begin to provide standards in each of these areas, and will inform future PCORI funding announcements and review criteria. The work of the Methodology Committee is intended to enable generation of information that is relevant and trustworthy for patients, and to enable decisions that improve patient-centered outcomes.
Eradication of Tumors in Pre-Clinical Models of Multiple Myeloma by Anti-CS1 Monoclonal Antibody HuLuc63: Mechanism of Action Studies.
Authors: Audie Rice, Myles Dillon, Anne van Abbema, Lynne Jesaitis, Melanie Wong, Stacey Lawson, Gao Liu, Yin Zhang, David Powers, Susan Rhodes, Ingrid Caras, Debbie Law, Daniel Afar
Journal: Blood (2006)