Acquired Syphilis With Anemia and Leukoerythroblastic Reaction: A Case Report
Authors: Kalyan C. Mantripragada, Sophia Fircanis Rizk, John L. Reagan, Mark LeGolvan
Journal: Annals of Internal Medicine (2016)

Letters2 August 2016Acquired Syphilis With Anemia and Leukoerythroblastic Reaction: A Case ReportKalyan C. Mantripragada, MD, MPH, Sophia Fircanis Rizk, MD, John L. Reagan, MD, and Mark LeGolvan, MDKalyan C. Mantripragada, MD, MPHFrom The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.Search for more papers by this author, Sophia Fircanis Rizk, MDFrom The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.Search for more papers by this author, John L. Reagan, MDFrom The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.Search for more papers by this author, and Mark LeGolvan, MDFrom The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L15-0527 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The number of cases of syphilis reported to the Centers for Disease Control and Prevention increased by 13.1% between 2012 and 2013 (1).Objective: To report an adult patient with acquired syphilis, extramedullary hematopoiesis, and involvement of the bone marrow and liver, which have been described previously only with congenital syphilis.Case Report: A 65-year-man presented to our hospital with 6 weeks of increasing fatigue, 20-lb weight loss, and temperature of up to 100.8 °F. In addition to having hypertension and type 2 diabetes mellitus, he was receiving long-term HIV prophylaxis because of a serodiscordant relationship with an HIV-positive male ...References1. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2013. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2014. Accessed at www.cdc.gov/std/stats13/syphilis.htm on 8 October 2015. Google Scholar2. Freiman I, Super M. Thrombocytopenia and congenital syphilis in South African Bantu infants. Arch Dis Child. 1966;41:87-90. [PMID: 5906632] CrossrefMedlineGoogle Scholar3. Levine Z, Sherer DM, Jacobs A, Rotenberg O. Nonimmune hydrops fetalis due to congenital syphilis associated with negative intrapartum maternal serology screening. Am J Perinatol. 1998;15:233-6. [PMID: 9565220] CrossrefMedlineGoogle Scholar4. Romeu J, Rybak B, Dave P, Coven R. Spirochetal vasculitis and bile ductular damage in early hepatic syphilis. Am J Gastroenterol. 1980;74:352-4. [PMID: 7457460] MedlineGoogle Scholar5. Pareek SS. Liver involvement in secondary syphilis. Dig Dis Sci. 1979;24:41-3. [PMID: 428289] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From The Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L15-0527.This article was published at www.annals.org on 22 March 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySystematic review about etiologic association to the leukoerythroblastic reaction 2 August 2016Volume 165, Issue 3Page: 226-227KeywordsAnemiaBone marrowCongenital syphilisFeversHIVHematopoiesisLiverPenicillinRapid plasma reaginSyphilis ePublished: 22 March 2016 Issue Published: 2 August 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...