tbuckley/cabot-search huggingface dataset:
Glucose Homeostasis in Viral Hepatitis
Authors: Philip Felig, W. Virgil Brown, Robert A. Levine, Gerald Klatskin
Journal: New England Journal of Medicine (1970)

Abstract Fasting hypoglycemia (plasma glucose level below 60 mg per 100 ml) was observed in eight of 15 consecutive patients with acute viral hepatitis. Plasma insulin levels were decreased 30 per cent in the eight hypoglycemic patients. The plasma glucose response to glucagon was 1/3 that of normal controls, and was not improved by a high-carbohydrate diet. In normal subjects, glucagon elicited a prompt reduction in plasma amino acid levels that was greatest for alanine and glycine. No consistent reduction in amino acid concentration after glucagon administration was observed in the hepatitis group. Liver glycogen content, determined histologically, was markedly reduced in the patients with hepatitis. Acute viral hepatitis results in serious impairment in hepatic glycogen synthesis and gluconeogenesis and frequently gives rise to fasting hypoglycemia.
Humanized mouse model of mast cell–mediated passive cutaneous anaphylaxis and passive systemic anaphylaxis
Authors: Paul J. Bryce, Rustom Falahati, Laurie L. Kenney, John Leung, Christopher Bebbington, Nenad Tomasevic, Rebecca A. Krier, Chia-Lin Hsu, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm
Journal: Journal of Allergy and Clinical Immunology (2016)
Benign Paroxysmal Peritonitis
Authors: Irving B. Brick, Mariano Cajigas
Journal: New England Journal of Medicine (1951)

RECENTLY, Reimann1 , 2 has collected a group of disorders recurring with rather regular periodicity over many years without otherwise affecting the general health. In different persons the episodes are characterized by different features that, in the person affected, remain remarkably constant in the recurrent attacks. He has classified the disorders into four groups on the basis of the outstanding feature in the attacks; for the whole group of disorders he has proposed the term "periodic disease." The groups are periodic fever, periodic abdominalgia (benign paroxysmal peritonitis), periodic (cyclic) neutropenia and periodic (intermittent) arthralgia. Theories concerning etiology are reviewed and the evidence . . .
304 EGR1 PROMOTES THE DIFFERENTIATION OF BM-DERIVED MESENCHYMAL STEM CELLS INTO FUNCTIONAL HEPATOCYTE WITH MESENCHYMAL-TO-EPITHELIAL TRANSITION
Authors: H.-L. Kim, J.H. Cha, N.R. Park, S.H. Bae, J.Y. Choi, S.K. Yoon
Journal: Journal of Hepatology (2013)
Abstract 5250: MUC1 expression is induced by Snai1 in an epithelial mesenchymal transition renal model
Authors: Viviane Gnemmi, Audrey Bouillez, Bélinda Ringot, Laurent Zini, Marie-Christine Copin, Isabelle VanSeuningen, Xavier Leroy, Michael Perrais, Aubert Sébastien
Journal: Cancer Research (2011)

Abstract Accumulating data suggest that epithelial mesenchymal transition (EMT) is involved in cancer progression. Sarcomatoid carcinoma represents a high-grade transformation and an EMT-like pattern. Up to 8% of conventional renal cells cancers (cRCC) present with sarcomatoid carcinoma component that portends a worse prognosis. MUC1, a membrane-bound glycoprotein is known to be over-expressed in cRCC with correlation to prognosis. Indeed, we showed that MUC1 overexpression is correlated with a metastatic phenotype using tissue microarray sampling 27 cRCC of same TNM stage. Also, we demonstrated in a series of 15 RCC with sarcomatoid component, the loss of epithelial markers and the acquisition of mesenchymal markers compared to conventional carcinomatous areas. MUC1 was significantly overexpressed along with Snai1, a major actor of EMT, in sarcomatoid component. So, we hypothesized that MUC1 could be regulated by Snai1. Bioinformatic analyses revealed two Snai1 E-boxes at -84/-72 on MUC1 promoter. Cotransfection studies of MUC1 promoter and Snai1 expression vectors in renal cells lines showed an induction of MUC1 transcriptional activity by luciferase assays. Mutagenesis site-directed of both Snai1 E-boxes in renal cells lines induced loss MUC1 transcriptional activity. By chromatin immunoprecipation assay and gel shift analysis we will demonstrate a direct interaction between Snai1 and MUC1 promoter. In conclusion, all these data revealed that MUC1, usually considered as an epithelial marker, is overexpressed during cancer linked EMT process with a direct regulation by Snai1 suggesting that MUC1 plays a role in renal cancer progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5250. doi:10.1158/1538-7445.AM2011-5250
SAT0029 Clinical Features and Risk Factors of Infection in Patients with Systemic Lupus Erythematosus: Experience from A Single Institute of Southern China
Authors: D. Chen, Z. Zhan
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> Infections commonly complicate the course of systemic lupus erythematosus (SLE). Our aim is to investigate the clinical features and potential clinical predictors of infections in patients with SLE. <h3>Methods</h3> A retrospective cohort study was performed among patients admitted to the First Affiliated Hospital of Sun Yet-sen University from January 2007 to June 2012. Demographic information, clinical and laboratory data and pathogen were collected. Univariate analysis and logistic regression models were used for the analysis of data. <h3>Results</h3> Among 2568 patients included, 1321 (51.44%) were diagnosed with infection, with the average age of 34.97±13.22 years old and the mean duration of SLE was 44.65±65.19 months (range 1-480 months). 1452 infections involving various microorganisms were recorded. Bacterial infection was predominant (49.66%), followed by viral infection (39.12%), fungal infection (7.30%) and <i>Mycobacterium</i> (3.93%) infections. The pulmonary was most commonly affected (37.81%). Less common sites of infection included upper respiratory tract, genitourinary tract, skin/soft tissue and so on. The most frequently found bacteria were <i>Escherichia coli</i> (26.63%), followed by <i>Acinetobacter baumannii</i> (13.43%) and <i>Staphylococcus aureus</i> (11.19%). 32.84% of the isolated bacteria were multi-drug resistant. <i>Herpes zoster</i> was the most common viral infection. The most common fungus was <i>Candida albicans</i> (74 episodes), followed by <i>Candida tropicalis</i> (8 episodes) and <i>Candida glabrata</i> (8 episodes). The mortality (1.74% vs. 0.80%, respectively) and average length of stay (19.88±14.84 days vs. 15.54±9.33 days, respectively) in patients with infection were both significantly higher than those in the patients without infection. The logistic regression multivariate analysis indicated that higher SLEDAI (OR=1.02, 95% CI: 1.00-1.03), lung disease (OR=1.80, 95%CI: 1.16-2.79),nephritis (OR=1.71, 95%CI: 1.45-2.21), anemia (OR=1.38, 95%: 1.13-1.69), elevated CRP (OR=1.04, 95% CI: 1.04-1.05) and treatment with higher dose cyclophosphamide (CYC) (≥1.0 g/m<sup>2</sup>/month) (OR=2.94,95%CI: 2.24-3.87) were positively associated with the occurrence of infections. <h3>Conclusions</h3> Infections were common in SLE patients, which increased both the mortality and average length of stay. The current study demonstrated that higher SLEDAI, lung disease, nephritis, anemia, elevated CRP and treatment with higher dose CYC were associated with the infection. It is concluded that a high level of suspicion and close monitoring of SLE patients with risk factors may ensure an optimal outcome. The judicious use of CYC is critical in limiting infections in SLE patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3052
Abstract 3826: Brevican absence and YKL-40 over-expression are associated to the mesenchymal profile and in vitro 3D-neurosphere growth of human glioma
Authors: Paloma Fernandez Martinez, Cristina Zahonero Casans, Natividad Pozo de la Rosa, Angel Ayuso, Rafael Garcia de Sola, Juan Manuel Sepulveda Sanchez, Pilar Sanchez Gomez
Journal: Cancer Research (2011)

Abstract DNA microarray-based molecular profiling have recently uncovered two well-differentiated subsets of human glioma having distinct clinical outcome: those displaying neuronal lineage markers and having longer survival (proneural), and those enriched for neural stem cell markers and having short survival (mesenchymal). Genes allowing the distinction of both glioma subsets were herein used to further explore their clinical and biological significance with regard to survival and tumorigenic potential through 3D-neurosphere in vitro assay. Surgical samples from 72 patients with glioma (tumor tissue and tumor-unaffected brain tissue from the same patients) were used. The expression level of most relevant genes, including cancer stem cell markers, matrix and tumor progression genes were analyzed by quantitative RT-PCR. Brevican (BCAN), Delta-like 3 (DLL3) and oligodendrocyte lineage transcription factor 2 (Olig2) genes were associated to the proneural profile (Spearman correlation between them indicated a robust P-value: DLL3-BCAN: 2.17E-10; Olig2-BCAN: 6.94E-9; Olig2-DLL3: 5.03E-11). In contrast, Fibronectin 1 (FN1) and cartilage glycoprotein-39 (YKL-40) gene over-expression defined the mesenchymal profile in an effective way (Spearman correlation YKL-40-FN1 p-value: 2.65E-4). Survival increased by two-fold in patients having BCAN gene over-expression. Moreover, BCAN gene expression prevented in vitro growth of glioma cells as 3D-neurospheres. These data demonstrate a correlation between BCAN, DLL3 and Olig-2 gene expression and the proneural glioma profile, while absence of BCAN expression and YKL40 overexpression was associated to the mesenchymal profile and in vitro neurosphere growth of human glioma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3826. doi:10.1158/1538-7445.AM2011-3826
Abstract 239: Biomarker profiling and combination studies of receptor tyrosine kinase inhibitors of EGFR, ERBB2, IGFR-1, FGFR and PDGFR
Authors: Christine L. O'Day, Yulia Ovechkina, Karen Marcoe, Robert Keyser, Jessica Chesnut-Speelman, James Hnilo
Journal: Cancer Research (2011)

Abstract Targeting Receptor Tyrosine Kinases (RTKs) for therapeutic efficacy has been a promising approach for modern oncological agents. However, not all cancers respond to these agents and understanding of the feedback and resistance mechanisms is not complete. We have used an In vitro cellular profiling of 240 genetically characterized tumor human cell lines to help understand genotypes that convey sensitivity and resistance to these agents. While most of the sensitive cell lines were unique to a given RTK inhibitor, many of the resistant cell lines had similar genotypes. We have investigated downstream genes for mutations, over-expression and phosphorylation status. Phosphorylation levels pAKT, pERK, and pJNK, and as well as basal levels of p27KIP, EGFR and ERBB2 protein levels were analyzed. Many of the downstream mutations or activated genes confer resistance to the RTK inhibitors such as AKT, PTEN and PI3K mutations. In addition to downstream activation, we have found that overexpressed RTKs often seem to confer resistance to other RTK inhibitors. For example, EGFR over-expressed cell lines disproportionately populated the group of cell lines resistant to an IGFR-1 receptor agonist. We have investigated cross talk between these various RTKs. Both EGFR and IGFR-1 inhibitors were tested in a combinatorial approach through 60 cell lines for synergy and antagonism. We evaluate synergy calculations through combination index and bliss analysis across 60 cell lines. Other combinations are also in the process of being tested for synergy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 239. doi:10.1158/1538-7445.AM2011-239
Hemostatic clips and magnetic resonance imaging. Are there any compatibility issues?
Authors: Georgios Mavrogenis, Milena Del Natale
Journal: Endoscopy (2013)

We read with interest the article by Olmez et al. [1] regarding the case of an Olympus endoclip (Olympus Medical Systems Corp., Tokyo, Japan) that had been retained for more than 2 years. According to the authors, endoclips may be retained for longer than expected, and they propose that a plain abdominal radiograph should be obtained before magnetic resonance imaging (MRI) because the stainless-steel hemostatic clips are contraindications to MRI for safety reasons.
Prevention of Radiographic-Contrast-Agent–Induced Reductions in Renal Function by Acetylcysteine
Authors: Martin Tepel, Marcus van der Giet, Carola Schwarzfeld, Ulf Laufer, Dieter Liermann, Walter Zidek
Journal: New England Journal of Medicine (2000)

Radiographic contrast agents can cause a reduction in renal function that may be due to reactive oxygen species. Whether the reduction can be prevented by the administration of antioxidants is unknown.
LONGITUDINAL ASSESSMENT OF SINGLE VENTRICLE PATIENTS IN THE PEDIATRIC HEART NETWORK FONTAN COHORT
Authors: Andrew M. Atz, Victor Zak, Lynn Mahony, Kristin Burns, David Goldberg, Richard Williams, Roger Breitbart, Rosalind Korsin, Steven Colan, Bradley S. Marino, Renee Margossian, Kaitlyn Daniels, Karen Uzark, Heather Henderson, Brian McCrindle
Journal: Journal of the American College of Cardiology (2015)
P125 Non-invasive assessment of ventilation distribution in infants using electrical impedance tomography (EIT)
Authors: P. A. Shah, H. Shannon, A.-F. Hoo, D. Ahmed, J. Chudleigh, J. Stocks
Journal: Thorax (2010)

<h3>Background</h3> Early detection of lung disease in conditions such as cystic fibrosis (CF) is vital to maximise lung health but lung function tests (LFT) during the 1st year of life are limited to a few specialised centres. Electrical Impedance Tomography (EIT) provides a novel non-invasive technique for measuring breathing patterns and regional ventilation but its use has generally been restricted to anaesthetised or ventilated subjects in intensive care.12 <h3>Aim</h3> To assess the feasibility and potential usefulness of EIT for monitoring changes in breathing pattern and ventilation distribution in spontaneously breathing sleeping infants. <h3>Methods</h3> Simultaneous recordings of EIT (Goe-MF II EIT system) and changes in tidal volume using a pneumotachograph (PNT) were made in the supine position in infants undergoing standard LFT under chloral sedation, before and after application of face mask and PNT, and during tidal breathing (TB) vs passive lung inflations (PLI) to 30cmH<sub>2</sub>O. <h3>Results</h3> To date, paired data have been obtained from 9/10 infants in whom measurements were attempted (aged 3–12 months: five=CF and four=healthy controls, one technical failure of EIT). Application of the face mask resulted in a mean (range) 27 (12–39)% increase in impedance. Compared with TB, PNT volume increased by mean (SD) 127 (20)% during PLI, which was accompanied by a 152 (22)% increase in impedance. During TB, ventilation was relatively evenly distributed between left (L) and right (R) lung, mean (SD) L/R:1.09 (0.22) and, as in adults, was preferentially distributed to the dependent (dorsal) lung (dorsal/ventral (D/V):1.36 (0.29)). During PLI, there was a significant shift in ventilation distribution to the left and ventral portions of the lung (mean (95% CI) L/R:1.29 (1.24; 1.35); D/V:0.89 (0.71;1.06)) (Abstract P125 Figure 1). Data collection is continuing. <h3>Conclusions</h3> These results suggest that EIT maybe a useful non-invasive method of monitoring changes in breathing pattern and ventilation distribution in spontaneously breathing infants. Despite suggestions that distribution of ventilation differs in infants, the preferential distribution to the dependent lung during tidal breathing mimics that seen in adults. Improvements in software and equipment will be required prior to routine applications.
Bakhtawar Shah Khattak
Authors: F. Khattak
Journal: BMJ (2013)

Bakhtawar Shah Khattak was born into a farming family in a remote village in the district of Karak in the northwest region of Pakistan. When he was 5, the family moved to Punjab to a small village, Sohrab Vala, then to Abba Khail, and then to district Mianwali city, where he passed primary school, won a scholarship, and passed middle school . He came third in the whole region, so …
P2-02-08: Int6 Regulates Both Proteasomal Degradation and Translation Initiation and Is Critical for Proper Formation of Acini by Human Mammary Epithelium.
Authors: J Suo, SJ Snider, RE Lloyd, EC Chang
Journal: Cancer Research (2011)

Abstract The mammalian INT6/EIF3E gene has been implicated in breast tumor formation, but its functional activities remain poorly defined. Consistent with the fact that Int6 is frequently down-regulated in human breast tumors, we found that repressing INT6 expression induced transformed properties in normal human mammary epithelial cells (MCF10A) in both 2D and 3D cultures. Int6 contains a PCI domain, found in several components of both the proteasome and the translation initiation factor eIF3, suggesting that it can functionally interact with both. Indeed, our data show that Int6 associates with proteasomes in human cells, and that INT6 knockdown prevents proper assembly of active proteasomes. In addition, we show that down-regulation of INT6 reduces translation initiation (both polysome formation and global protein synthesis). However, Int6 regulates translation selectively, reducing translation from cap-dependent and Bcl2- IRES reporters, but stimulating translation from the CVB3 IRES. These data collectively suggest that Int6 controls both protein synthesis and protein degradation, and is thus capable of fine-tuning protein levels. Abnormal levels of regulatory proteins caused by Int6 abnormalities may thus be responsible for disrupting normal morphogenesis of mammary epithelial cells and causing transformed phenotypes. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-02-08.
Breast Cancer Surveillance: On Increasing Its Effectiveness While Reducing Its Negative Psychological Effects
Authors: Barrie R. Cassileth
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Breast Cancer Surveillance: On Increasing Its Effectiveness While Reducing Its Negative Psychological Effects Get access Barrie R. Cassileth Barrie R. Cassileth Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 1, 1 January 1992, Page 2, https://doi.org/10.1093/jnci/84.1.2 Published: 01 January 1992 Article history Received: 27 November 1991 Accepted: 27 November 1991 Published: 01 January 1992
Successful treatment of anastomotic jejunal varices with N-butyl-2-cyanoacrylate (Histoacryl): single-center experience
Authors: C. Gubler, M. Glenck, T. Pfammatter, P. Bauerfeind
Journal: Endoscopy (2012)

Obscure gastrointestinal bleeding can lead to extensive diagnostic work-up, as well as repeated episodes of hospitalizations with significant morbidity. Patients with a previous small-bowel anastomosis seem to be prone to varices at this site, even in the absence of portal hypertension. We report here five cases with varices of this type. All the anastomoses in these patients were reached using overtube-assisted single- or double-balloon enteroscopy. The bleeding varices were treated by injecting N-butyl-2-cyanoacrylate (Histoacryl). Bleeding was stopped in all five patients without any adverse events, requiring one session in four patients and a second session in one patient.
AB0029 Imbalance between Immunoregulatory and Effector TH17 Pathway in Active Sle
Authors: B. Jakiela, W. Kleczynska, J. Kosalka, H. Plutecka, M. Sanak, J. Musial
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Defective function of regulatory T cells (Treg) leads to the impairment of immune tolerance implicated in the pathogenesis of autoimmune inflammation in systemic lupus erythematosus (SLE). <h3>Methods</h3> To investigate the role of Treg in SLE we studied peripheral blood Treg and CD4+ effector T-helper cells (Th1, Th17), expression of their signature cytokines by in vitro activated lymphocytes (real-time PCR), and levels of TGF-β1, IL-10 and IL-17A (ELISA) in sera from patients with active–SLE (n=13), inactive-SLE (n=13) and matched healthy subjects (n=13). <h3>Results</h3> There was a significant decrease in CD4+ lymphocyte count in active SLE, with no evident difference in the percentage of CD25+FoxP3+ Treg cells as compared to other groups. Treg absolute counts decreased significantly in active-SLE (∼2-fold as compared to controls) and weakly correlated with markers of disease activity (C4, r=0.44). Only Th1 (IFN-γ producing) cells, but not Th17 (IL-17A producing) cells decreased in active disease, resulting in lower Th1/Th17 ratio. This was confirmed by a lower expression of IFN-γ mRNA (but not IL-17A) in peripheral blood lymphocytes from patients with active-SLE. All patients with SLE were characterized by lower Treg/Th17 ratio (median 1.4 vs. 2.4 in controls, p&lt;0.001). Additionally, in patients with SLE exacerbation we observed higher levels of serum IL-17A (p&lt;0.05 vs. controls) together with a decrease in concentration of immunoregulatory TGF-β1 (p&lt;0.05) and elevated IL-10 (p&lt;0.01) as compared to other groups. However, only IL-10 correlated with SLEDAI score (r=0.57) and negatively with levels of C4 (r=-0.59), probably as a compensatory mechanism related to immune activation. <h3>Conclusions</h3> Our data suggest, that SLE associated lymphopenia affects primarily Treg and Th1, but not Th17 fraction, resulting in imbalance between regulatory and effector CD4+ subsets. This may lead to relative deficiency in suppressive function of Treg (as evidenced by decrease in TGF-β1), and consequently to the increased proinflammatory response during active phase of the disease. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3602