tbuckley/cabot-search huggingface dataset:
Professor Neil Pride
Authors: Peter J Barnes, Mike Hughes
Journal: Thorax (2017)

![Graphic][1]</img> Professor Neil Blair Pride MD, FRCP, FERS: born Croydon 29 July 1931, died Ealing 12 November 2016 . Neil Pride, Emeritus Professor of Respiratory Medicine at Imperial College London, died on 12 November 2016, aged 85 years. He was a world-renowned respiratory physician and physiologist who made enormous contributions to our understanding of common lung diseases. He was an active member of the British Thoracic Society (BTS) and served as President from 1992 to 1993. Neil was born in Croydon to a general practitioner father and educated at Bryanston School, Dorset. He studied preclinical medicine at Christ's College, Cambridge University, and went on to do clinical studies at St Mary's Medical School in London, qualifying as a doctor in 1956. After clinical training posts in London and Cambridge, in 1962 he went to work with Sol Permutt in the Department of Medicine at Johns Hopkins University in Baltimore, USA. It was here that he developed his physiological research, … [1]: /embed/inline-graphic-1.gif
Comparable Results of HLA Identical Sibling Donor Peripheral Blood Hematopoietic Stem Cell Transplantation after Reduced-Intensity and High-Dose TBI-Based CD34+-Positive Cell Selection Myeloablative Preparative Regimens for High-Risk Myelodysplasia or Acute Myeloid Leukemia in First Remission: Results from a Prospective Study.
Authors: Rodrigo Martino, David Valcarcel, Jose L. Pinana, Anna Sureda, Salut Brunet, Javier Briones, Blanca Sanchez, Julio Delgado, Jorge Sierra
Journal: Blood (2006)
A Ruxolitinib Individual Supply Program for Patients with Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
Authors: Giovanni Barosi, Francisco Cervantes, Dina Ben-Yehuda, Panagiotis Panagiotidis, Jose Ricardo Perez, Nancy D. Orlando-Harper, Nicolas Martin, Wolfgang Willenbacher, Emilio Ojeda, Heinz Gisslinger, Laurent Knoops
Journal: Blood (2011)
STUDIES ON BACTERIAL ENZYMES
Authors: James M. Neill, William L. Fleming
Journal: The Journal of Experimental Medicine (1927)

The meningococcus cell contains a peptonase enzyme which hydrolyzes the peptides and similar constituents of commercial "peptone." The activity of this enzyme is independent of the presence of the formed bacterial cell. The peptonase enzyme is more resistant to heat and to oxidation than is the maltase enzyme of the same bacteria.
Nab-paclitaxel versus solvent-based paclitaxel in patients with previously treated advanced gastric cancer (ABSOLUTE): an open-label, randomised, non-inferiority, phase 3 trial
Authors: Kohei Shitara, Atsuo Takashima, Kazumasa Fujitani, Keisuke Koeda, Hiroki Hara, Norisuke Nakayama, Shuichi Hironaka, Kazuhiro Nishikawa, Yoichi Makari, Kenji Amagai, Shinya Ueda, Kazuhiro Yoshida, Hideki Shimodaira, Tomohiro Nishina, Masahiro Tsuda, Yukinori Kurokawa, Takao Tamura, Yasutsuna Sasaki, Satoshi Morita, Wasaburo Koizumi
Journal: The Lancet. Gastroenterology & hepatology (2017)
Allogeneic Stem Cell Transplantation (allo-SCT) in Patients with Secondary Acute Myelogenous Leukemia (AML) or High Risk Myelodysplastic Syndromes (MDS).
Authors: Jean El-Cheikh, Catherine Faucher, Mohamad Mohty, Anne-Marie Stoppa, Marina Lafage-Pochitaloff, Diane Coso, Marie-Joelle Moziconacci, Reda Bouabdallah, Jean-Albert Gastaut, Didier Blaise, Norbert Vey
Journal: Blood (2005)
Correction of Post-Transplant Hematopoiesis by Novel Use of Mesenchymal-Like Placental Expanded Cells (PLX) Administered Intra-Muscular
Authors: Reuven Or, Sigal Grisaro, Batia Ronit Avni, Igor Resnick, Lilyan Dari, David Shoshani, Dalia Bracha, Nurit Beilin, Limor Lior, Michael Y. Shapira
Journal: Blood (2012)
PET-CT Adapted Therapy After 3 Cycles of ABVD for All Stages of Hodgkin Lymphoma. Interim Analysis in 173 Patients
Authors: Santiago Pavlovsky, Astrid Pavlovsky, Isolda Fernandez, Miguel Pavlovsky, Virginia Prates, Lucia Zoppegno, Ana Lisa Basquiera, Ider Cerutti, Andrea Rodriguez, Gustavo Milone, Vanesa Castano, Silvia Rudoy, Federico Sackmann, Lourdes Valles, Francisco Lastiri
Journal: Blood (2010)
Comprehensive Assessment of Clinical Outcomes for CLL Patients with Trisomy 12 (+12): Results of a Population-Based Analysis of 822 CLL Patients in British Columbia (BC), Canada
Authors: Alina S. Gerrie, Steven J.T. Huang, Helene Bruyere, Chinmay B. Dalal, Monica Anne Hrynchak, Aly Karsan, Khaled M Ramadan, Adam C. Smith, Tanya L. Gillan, Cynthia L. Toze
Journal: Blood (2012)
Flow Cytometric Characteristics of CD34+ Cells in Refractory Anemia: Their Diagnostic Value.
Authors: Kiyoyuki Ogata, Yoshifumi Kishikawa, Tomoko Shimazaki, Chikako Satoh, Hideto Tamura, Yoshihiko Otsuka, Kazuo Dan, Akio Hayashi, Mitsunobu Shimazu
Journal: Blood (2005)
Autocrine TNF-α Signaling in Hematopoietic Stem Cells Promotes Myeloproliferative Disease Progression through Activation of TNFR2
Authors: William L. Heaton, Anna V. Senina, Anthony D. Pomicter, James E Marvin, Sabina Swierczek, Anna M. Eiring, Josef T. Prchal, Thomas O'Hare, Michael W. Deininger
Journal: Blood (2014)
Expression of Phosphorylated Signal Transducer and Activator of Transcription 5 (pSTAT5) Is Associated with An Increased Risk of Death In Acute Myeloid Leukemia.
Authors: Anna Brady, Sarah Gibson, Lisa Rybicki, Eric Hsi, Edward Copelan, Matt Kalaycio, Mikkael A. Sekeres, Ronald Sobecks, Yogen Saunthararajah, Jennifer Bates, Anjali S. Advani
Journal: Blood (2010)
Erythropoietic Stimuli and Response in Hereditary Spherocytosis
Authors: Susana Rocha, Petronila Rocha-Pereira, Elisabeth Bayer Castro, Esmeralda Cleto, Fátima Ferreira, Marika Antunes, José Barbot, Alexandre Quintanilha, Luís Belo, Alice Santos-Silva
Journal: Blood (2008)
of MiR-449a Is Essential for the Survival of EVII Positive Leukemic Cells through Modulation of NOTCH1 and BCL2
Authors: An De Weer, Pieter Mestdagh, Katleen De Preter, Joni Van der Meulen, Pieter Van Vlierberghe, Tom Van Maerken, Nadine Van Roy, Marta Jeison, Isaac Yaniv, Barbara Cauwelier, Lucien Noens, Helene-Antoine Poirel, Peter Vandenberghe, Frederic Lambert, Anne De Paepe, Torsten Konrad, Rotraud Wieser, Maria Garcia Sanchez, Maria Odero, Bruno Verhasselt, Jan Philippe, Jo Vandesompele, Nicole Dastugue, Bruce Poppe, Frank Speleman
Journal: Blood (2009)
CLL with Mutated IGHV4-34 Antigen Receptors Is Clinically Heterogeneous: Antigen Receptor Stereotypy Makes the Difference
Authors: Aliki Xochelli, Panagiotis Baliakas, Andreas Agathangelidis, Anastasia Hadzidimitriou, Lesley-Ann Sutton, Eva Minga, Eugen Tausch, Xiao J. Yan, Tait D. Shanafelt, Karla Plevova, Myriam Boudjogra, Davide Rossi, Zadie Davis, Alba Navarro, Yorick Sandberg, Fie Juhl Vojdeman, Lydia Scarfo, Niki Stavroyianni, Andrey B. Sudarikov, Silvio Veronese, Tatiana Tzenou, Teodora Karan-Djurasevic, Mark Catherwood, Dirk Kienle, Maria Chatzouli, Monica Facco, Jasmin Bahlo, Lone Bredo Pedersen, Larry Mansouri, Karin E Smedby, Charles C Chu, Véronique Giudicelli, Marie-Paule Lefranc, Panagiotis Panagiotidis, Gunnar Juliusson, Achilles Anagnostopoulos, Darko Antic, Livio Trentin, Marco Montillo, Carsten Niemann, Hartmut Döhner, Anton W. Langerak, Nikos Darzentas, Sarka Pospisilova, Michael Hallek, Elias Campo, Nicholas Chiorazzi, David Oscier, Gianluca Gaidano, Chrysoula Belessi, Diane F. Jelinek, Stephan Stilgenbauer, Frederic Davi, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood (2015)
Daily Practice Experience in Ponatinib Treatment of Chronic Myeloid Leukemia (CML) Patients Resistant to Other Tyrosin Kynase Inhibitors (TKIs) in Argentina
Authors: Ana Inés Varela, Romina Laura Penalba, Alicia Enrico, Marta Catalan, Maria Veronica Ventriglia, Maria Josefina Freitas, Carolina Pavlovsky, Susana Garbiero, Martin Beccasese, Raquel Maria Nelida Bengio, Catalina Abramovich, Miguel A Pavlovsky, Elena Beatriz Moiraghi
Journal: Blood (2015)
Hyperhomocysteinemia in Cancer Patients with Thrombosis Is Independent of Methylene Tetrahydrofolate Reductase Gene Mutation.
Authors: Jawed Fareed, Mahmut Tobu, Debra A. Hoppensteadt, Josephine Cunanan, Omer Iqbal, Muzaffer Demir, Steven Deitcher
Journal: Blood (2004)
Inhibition of Factor XIIa-Mediated Factor XI Activation Reduces Infarct Size in a Mouse Model of Myocardial Ischemia and Reperfusion
Authors: Christina U Lorentz, Norah G Verbout, Zhiping Cao, Helen Liu, Owen J.T. McCarty, Erik I. Tucker, Andras Gruber, Donna Van Winkle
Journal: Blood (2014)
A Phase I, Multi-Center, Dose Escalation Study of Atiprimod in Patients with Refractory or Relapsed Multiple Myeloma (MM).
Authors: Michael Wang, Moshe Talpaz, Sundar Jagannath, Asher Alban Chanan-Khan, Raymond Alexanian, Donna M. Weber, Maria Gavino, Zeev Estrov, Pamela J. Harris, Donald Picker, Robert L. Schlossman, Pierfrancesco Tassone, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2005)
GATA-1 Enhances the Transcription of PIGM and Is Responsible for Increased GPI Expression in Erythrocytes in Inherited Glycosylphosphatidylinositol Deficiency: A Model for Tissue-Specific Housekeeping Gene Transcription Regulation
Authors: Joana S Costa, Madalena Nolasco, Antonio M Almeida, Irene Roberts, Mark Layton, Anastasios Karadimitris
Journal: Blood (2008)
Differentially Cleaved Forms of Osteopontin by Thrombin and Carboxypeptidase B (TAFIa) Regulates Neutrophil Viability and Synoviocyte Binding in Rheumatoid Arthritis
Authors: Shadi Sharif, Xiaoyan Du, Timothy Myles, Jason Jungsik Song, Elizabeth A Price, David Lee, Stuart Goodman, John Morser, William Robinson, Lawrence L. Leung
Journal: Blood (2008)
Phase 1/2 Study of SB1518, a Novel JAK2/FLT3 Inhibitor, In the Treatment of Primary Myelofibrosis
Authors: Srdan Verstovsek, H. Joachim Deeg, Olatoyosi Odenike, Joy Zhu, Hagop Kantarjian, Zeev Estrov, Bart Lee Scott, Deborah A Thomas
Journal: Blood (2010)
Nonalcoholic Steatohepatitis (NASH) and Hepatic Fibrosis: Emerging Therapies
Authors: Julia Wattacheril, Danny Issa, Arun Sanyal
Journal: The Annual Review of Pharmacology and Toxicology (2017)

Nonalcoholic fatty liver disease remains a major cause of liver-related morbidity and mortality worldwide. It is a complex disease associated with obesity, diabetes, and dyslipidemia but is increasingly recognized in normal-weight individuals. Its progressive inflammatory phenotype, nonalcoholic steatohepatitis (NASH), currently has no effective treatment apart from lifestyle interventions. Multiple pathogenic pathways are involved in disease progression, and targets for intervention have been identified. These targets mediate glucose, lipid, and bile acid metabolism; inflammation; apoptosis; and fibrosis. Novel therapeutic agents are being developed in each of these pathways, and several have shown promise in early phase testing. Given the complexity of the disease, intervention trials are large and long and require histologic confirmation as a primary endpoint for disease improvement or regression. We highlight active Phase 2 and 3 therapeutic trials for NASH as this field rapidly expands in development.
Final Results of a Phase II Trial of Belinostat (PXD101) in Patients with Recurrent or Refractory Peripheral or Cutaneous T-Cell Lymphoma.
Authors: Brad Pohlman, Ranjana Advani, Madeleine Duvic, Kenneth B. Hymes, Tanin Intragumtornchai, Arnuparp Lekhakula, Ofer Shpilberg, Adam Lerner, Dina Ben-Yehuda, Marie beylot-Barry, Uwe Hillen, Jan Fagerberg, Francine M Foss
Journal: Blood (2009)
Abstract 13143: The Relationship Between Coronary Microvascular Dysfunction and Preclinical Left Ventricular Diastolic Dysfunction: Invasive Physiologic and Echocardiographic Study
Authors: Yuhei Kobayashi, Yukari Kobayashi, Francois Haddad, Vedant Pargaonkar, David P Lee, William F Fearon, Alan C Yeung, Jennifer A Tremmel
Journal: Circulation (2015)

Background: Microvascular dysfunction has been associated with the development of diastolic heart failure. We hypothesized that invasively assessed microvasculature is related to diastolic function as assessed by echocardiography, even before the development of diastolic heart failure. Methods: We prospectively enrolled 63 subjects with preserved ejection fraction (≥55%) and no heart failure symptoms. Coronary physiologic assessment, including fractional flow reserve (FFR), coronary flow reserve (CFR), and the index of microcirculatory resistance (IMR), was performed in the LAD. Coronary flow was assessed with a thermodilution method by obtaining a mean transit time (Tmn: an inverse correlate to absolute flow) at rest and hyperemia. IMR was measured as distal coronary pressure x hyperemic Tmn. Left ventricular diastolic function was evaluated by an echocardiographic parameter (E/e’) using the following criteria; normal E/e’&lt;8, intermediate 8&lt;E/e’&lt;15, and high E/e’&gt;15, where a higher value was correlated with diastolic dysfunction. Results: Mean age was 54.5±12.3 years. All subjects had no significant stenosis in the LAD (FFR: 0.87±0.05). Mean CFR and IMR were 4.4±1.9 and 18.2±8.3, respectively. CFR and IMR were not significantly different among the 3 E/e’ groups (ANOVA p=0.60 for CFR and p=0.14 for IMR). Conversely, both resting and hyperemic Tmn were significantly shorter in patients with a high E/e’ value than with a normal value (p=0.04 for resting Tmn and p=0.03 for hyperemic Tmn, Figure), suggesting that coronary flow both at rest and hyperemia increases along with the progression of diastolic dysfunction. Conclusions: In this preclinical population, invasively assessed microvascular function (CFR/IMR) is not associated with diastolic dysfunction, whereas both resting and hyperemic flow are increased in subjects with diastolic dysfunction. Future studies are warranted to test the prognostic value of increased coronary flow.
Pre Transplant Values of C Reactive Protein (CRP) and Brain Natriuretic Peptide (BNP) as Predictors of Transplant Outcomes in Patients with Acute Myelogenous Leukemia or Myelodysplastic Syndromes (AML/MDS) Undergoing Allogeneic Stem Cell Transplantation (AlloSCT).
Authors: Sergio Giralt, Rima M. Saliba, Floralyn Mendoza, Gaurav Parikh, Suheil Qureshi, Weiqing Zhang, Uday Popat, Muzaffar Qazilbash, Issa Khouri, Chitra Hosing, Amin Alousi, Paolo Anderlini, Borje Andersson, Roy Jones, Elizabeth Shpall, Partow Kebriaei, Yago Nieto, Naoto Ueno, Richard Champlin, Marcos de Lima
Journal: Blood (2007)
New Insights on Assessing Intra-Family Selectivity for Jak2 Inhibitors
Authors: Liqin Liu, Violeta Yu, Jeanne Pistillo, Josie Lee, Laurie B Schenkel, Stephanie Geuns-Meyer, Ivonne Archibeque, Angus Sinclair, Renee Emkey, Graham Molineux
Journal: Blood (2011)
Decreased TAp63 and ΔNp63 mRNA Levels in Most Human Pituitary Adenomas Are Correlated with Notch3/Jagged1 Relative Expression
Authors: Lisiane Cervieri Mezzomo, Frederico Giacomoni Pesce, Josenel Maria Barcelos Marçal, Taiana Haag, Nelson Pires Ferreira, Julia Fernanda Semmelmann Pereira Lima, Carolina Garcia Soares Leães, Miriam Costa Oliveira, Maria Beatriz da Fonte Kohek
Journal: Endocrine Pathology (2017)
Granulocytic Sarcoma (GS) Is Associated with Event-Free Survival Superior to That of Acute Myeloid Leukemia (AML).
Authors: Apostolia-Maria Tsimberidou, Michael J. Keating, Hagop M. Kantarjian, Susan O’Brien, Jorge Cortes, Charles Koller, Francis Giles, Sherry Pierce, Mark Brandt, Miloslav Beran, Elihu Estey
Journal: Blood (2006)
Expression of Angiopoietins and Their Receptor Tie2 in the Bone Marrow of Patients with Acute Myeloid Leukemia.
Authors: Christoph Schliemann, Ralf Bieker, Teresa Padro, Torsten Kessler, Heike Hintelmann, Thomas Buchner, Wolfgang E. Berdel, Rolf M. Mesters
Journal: Blood (2006)
Late effects in survivors of infantile acute leukemia: a study of the L.E.A program
Authors: V Gandemer, J Bonneau, C Oudin, J Berbis, Y Bertrand, M-D Tabone, S Ducassou, P Chastagner, B Brethon, J-H Dalle, S Thouvenin, M Poiree, D Plantaz, J Kanold, N Sirvent, P Lutz, Z Hamidou, A Baruchel, G Leverger, P Auquier, G Michel
Journal: Blood Cancer Journal (2017)
The Epigenetic Therapies Azacitidine and Sodium Valproate Augment Immune Responses to the MAGE Cancer Testis Antigen in Acute Myeloid Leukemia and Myeloma.
Authors: Oliver Charles Goodyear, Angelo Agathanggelou, Gordon Ryan, Igor Novitsky-Basso, Tatjana Stankovic, Paul Moss, Charles F. Craddock
Journal: Blood (2009)
Phase I/II Gene Therapy Study for Chronic Granulomatous Disease: Results, Lessons and Perspectives.
Authors: Marion G. Ott, Stefan Stein, Stephan Schultze-Strasser, Anna Jauch, Barbara Burwinkel, Brigitte Schlegelberger, Gudrun Goehring, Carolin Preiss, Rolf Kramer, Kerstin Schwarzwaelder, Ulrike Koehl, Hanna Kunkel, Klaus Kuehlcke, Andrea Schilz, Manfred Schmidt, Christof von Kalle, Adrian Trasher, Dieter Hoelzer, Reinhard Seger, Manuel Grez
Journal: Blood (2007)
Phase II Evaluation of the Tyrosine Kinase Inhibitor MLN518 in Patients with Acute Myeloid Leukemia (AML) Bearing a FLT3 Internal Tandem Duplication (ITD) Mutation.
Authors: Daniel J. De Angelo, Richard M. Stone, Mark L. Heaney, Stephen D. Nimer, Ronald Paquette, Rebecca Bruner-Klisovic, Michael A. Caligiuri, Michael R. Cooper, Jean-Michel LeCerf, Ganesh Iyer, Michael C. Heinrich, Brian J. Druker
Journal: Blood (2004)
Clinical Complications in Adult Patients with Sickle Cell Anemia and β-Thalassemia-Sickle Cell Disease
Authors: Giovanna Graziadei, Alessia Marcon, Martina Soldarini, Ilaria Gandolfi, Luisa Ronzoni, Marianna Giuditta, Pietro Ridolfi, Maria Domenica Cappellini
Journal: Blood (2012)
Derivation and initial characterization of three new prostate cancer cell lines and three new immortalized normal prostate epithelial cell lines
Authors: James F. Eliason, Panteli Theocharous, Bernadette Palazzolo, Aisha Mehmood
Journal: Cancer Research (2004)

792  Continuously growing lines of cancer cells have been invaluable for studies on various types of cancer. For prostate cancer, only a few different lines are available. We have derived three new prostate cancer cell lines from tissues obtained at the time of prostatectomy. The tissues were cut into small pieces with sterile scissors placed in keratinocyte serum free medium (KSFM), centrifuged, resuspended in KSFM and layered onto tissue culture plastic pre-coated with FCS. Growth was achieved by culturing the disrupted tissue in KSFM supplemented with huEGF and 2% FCS. When cell proliferation was evident, the cells were exposed to a replication-defective retrovirus transferring the transforming HPV16 or HPV18 E6 and E7 genes, as well as neoR, conferring Geneticin®-resistance. Transformed cells were then selected using Geneticin®. All primary cultures were maintained through crisis until a viable permanent cell line had been established. These lines are termed OPCT-1, OPCT-2 and OPCT-3. In a similar way, three new immortalized normal prostate epithelial cell lines have been derived from prostatectomy tissue. These lines are OPCN-1, OPCN-2 and OPCN-3. The doubling times (Td), calculated from a series of growth curves, suggest that the tumor lines proliferate more rapidly than the normal lines with Td of 1.1 ± 0.02 (SEM) days for OPCT-1, 1.8 ± 0.2 days for OPCT-2 and 1.9 ± 0.3 days for OPCT-3 compared to 2.7 ± 0.5 of OPCN-1, 2.9 ± 0.5 for OPCN-2 and 2.5 ± 0.5 days for OPCN-3. Immunohistochemistry results indicate that OPCT-1 is positive for cytokeratins 18 (CK18+), 5 and 8 (CK5/8+), vimentin, MUC-1 and flotillin. It is negative for desmin, alpha smooth muscle actin, and factor 8. The other lines have similar profiles for these markers, although OPCT-2 and OPCN-1 are only weakly positive for flotillin and OPCN-2 appears to be negative. For MUC-1, OPCN-2 and OPCT-2 are weekly positive. All lines appear to be negative for androgen receptor and positive for prostate stem cell antigen (PSCA). OPCT-2 is negative for PSA whereas the other three lines appear to be weakly positive. OPCT-3 and OPCN-3 have not been examined yet. These lines should be valuable tools for prostate cancer research. This work was supported in part by Asterand, Inc., Detroit, MI 48201.
Bortezomib Overcomes Cell Adhesion-Mediated Drug Resistance Via Down-Regulation of VLA-4 Expression in Multiple Myeloma.
Authors: Kaoru Hatano, Jiro Kikuchi, Masaaki Takatoku, Rumi Shimizu, Taeko Wada, Masuzu Ueda, Masaharu Nobuyoshi, Iekuni Oh, Kazuya Sato, Takahiro Suzuki, Katsutoshi Ozaki, Masaki Mori, Tadashi Nagai, Kazuo Muroi, Yasuhiko Kano, Yusuke Furukawa, Keiya Ozawa
Journal: Blood (2008)
Occupational exposure to pesticides: time to nip it in the bud?
Authors: K Mortimer, J Feary
Journal: Thorax (2017)

In Thorax, Negatu et al describe two cross-sectional studies exploring the effects of exposure to pesticides on lung health in commercial farming systems in Ethiopia. 1 They found a markedly increased risk of chronic cough and shortness of breath and impaired ventilatory function in exposed versus unexposed groups.These studies are the largest of their kind conducted in Ethiopia or the wider sub-Saharan Africa. 2 The finding that exposure to pesticides is associated with an increased risk of respiratory symptoms, airways disease and impaired ventilator function is, however, not new.Mamane et al 2 published a review of the literature on occupational exposure to pesticides and lung health in 2015 that included 36 studies involving agricultural workers.The studies included in the review were broadly consistent in finding a positive association between occupational exposure to pesticides and a range of markers of lung health. 2 In the UK, a high-income country, only 15% of workers have access to occupational health.It is therefore not a surprise that occupational health might be neglected in Ethiopia and other low/ middle-income countries under pressure from overwhelming social, economic and political challenges. 3 Education about the risks of pesticide exposure is needed at all levels from farm workers to policy and decision makers.Previous studies have suggested low levels of knowledge and awareness of potential health hazards among farmers elsewhere in sub-Saharan Africa. 4 5Negatu et al focus on respiratory health, but pesticides can also be neurotoxic and are estimated to be responsible for 220 000 deaths a year in low/middle-income countries alone due to intentional and accidental acute
Change in pulmonary mechanics and the effect on breathing pattern of high flow oxygen therapy in stable hypercapnic COPD
Authors: Lara Pisani, Luca Fasano, Nadia Corcione, Vittoria Comellini, Muriel Assunta Musti, Maria Brandao, Damiano Bottone, Edoardo Calderini, Paolo Navalesi, Stefano Nava
Journal: Thorax (2017)

: We studied the effects of high flow oxygen therapy (HFOT) versus non-invasive ventilation (NIV) on inspiratory effort, as assessed by measuring transdiaphragmatic pressure, breathing pattern and gas exchange. Fourteen patients with hypercapnic COPD underwent five 30-min trials: HFOT at two flow rates, both with open and closed mouth, and NIV, applied in random order. After each trial standard oxygen therapy was reinstituted for 10 min. Compared with baseline, HFOT and NIV significantly improved breathing pattern, although to different extents, and reduced inspiratory effort; however, arterial carbon dioxide oxygen tension decreased but not significantly. These results indicate a possible role for HFOT in the long-term management of patients with stable hypercapnic COPD.NCT02363920.
A Phase II Study of Yttrium-90-Ibritumomab Tiuxetan In Combination with a Fludarabine-Based Reduced Intensity Regimen Followed by Allogenic Stem Cell Transplantation In Patients with Relapsed or Chemorefractory CD 20 Positive Non-Hodgkin's Lymphoma.
Authors: Krimo Bouabdallah, Sabine Furst, Reda Bouabdallah, Stephane Vigouroux, Reza Tabrizi, Cyril Melot, Steven Le Gouill, Nathalie Fegueux, Mohamad Mohty, Didier Blaise, Noel-Jean Milpied
Journal: Blood (2010)