tbuckley/cabot-search huggingface dataset:
Educate small holders to contain bird flu, say experts
Authors: Jane Parry
Journal: BMJ (2005)

Farmers in South East Asia will have to radically change the way they house, rear, and slaughter poultry to combat the risk to human and animal health caused by the outbreak of H5N1 avian influenza, say experts. With concerted and coordinated action in the region, especially among small scale and backyard farmers, there still remained a window of opportunity to bring the avian flu situation under control, said health and agriculture specialists attending an international conference in Kuala Lumpur, Malaysia.

The conference included representatives from the World Health Organization, the United Nations' Food and Agriculture Organization, and the World Organization for Animal Health. Their aim was to formulate a workable plan to help affected countries tackle H5N1 avian influenza, which has so far infected at least 108 people in South East Asia, killing 54 and raising the spectre of a global pandemic.

A priority of the agreed plan was the need to educate smallholders and their families about how to reduce risk in their farming practices by segregating different species, such …
Guide for the Medical Use of Radioactive Isotopes
Authors: R J CAFFREY, T J FRITZLEN
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MB-55THE ROLE OF HIGH-DOSE MYELOABLATIVE CHEMOTHERAPY (HDCT) WITH AUTOLOGOUS HAEMATOPOIETIC STEM CELL TRANSPLANTATION (HSCT) IN CHILDREN WITH MEDULLOBLASTOMA: RESULTS OF A SYSTEMATIC REVIEW
Authors: Caroline Main, Barry Pizer, Keith Wheatley, Katherine Cooper, Madeline Adams, Simon Stevens, Martin English, Bob Phillips, Sophie Wilne, Pamela R. Kearns, Jayne S. Wilson
Journal: Neuro-Oncology (2016)
CASE REPORT
Authors: PHILIP E. HERTZ, ENDRE NADAS, HENRY WOJTKOWSKI
Journal: American Journal of Psychiatry (1955)

1. A case of Cushing's Syndrome in a 23-year old male is presented. 2. Proper diagnosis was delayed by an overwhelming psychotic picture, resembling schizophrenia. 3. Initial treatment consisting of a 2-stage roentgen irradiation of the pituitary region was rendered, producing no significant mental improvement. 4. Final treatment consisting of complete adrenalectomy, performed in 2 stages and followed by replacement therapy, resulted in complete remission of all physical and mental symptoms and signs within 6 months, following the first stage of adrenalectomy.
OP23 Vascular endothelial growth factor activation of liver sinusoidal endothelial cells via vascular endothelial growth factor receptor-2 regulates hepatocellular hepatitis C virus replication
Authors: I Rowe, P Lalor, D Adams, P Balfe, J McKeating
Journal: Gut (2010)

Introduction  Hepatitis C virus (HCV) is a major concern for human health, with an estimated 180 million people infected worldwide. HCV primarily infects hepatocytes in the liver and the majority of infected subjects develop progressive liver disease. Treatment options remain limited and hence, there is an urgent need for new therapies that target viral and host cell pathways. Vascular endothelial growth factor (VEGF) is a multifunctional cytokine that is produced by a variety of cell types in response to low oxygen and viral infections. VEGF targets vascular endothelial cells that are present in many tissues, including liver sinusoidal endothelial cells (LSEC). LSEC are in close apposition to hepatocytes in the liver and VEGF is known to regulate LSEC proliferation and function.  Aim  We recently demonstrated that HCV promotes VEGF expression in hepatocytes (Mee et al, 2010  Gastroenterology ) and the aim of this study was to investigate the role of VEGF in LSEC-hepatocyte interactions in HCV infection.  Method  Using primary human LSEC we established direct LSEC-hepatocyte co-culture models to recapitulate the hepatic microenvironment. The effects of VEGF on LSEC and hepatocytes were analysed in both monoculture and co-culture.  Results  Initial studies demonstrated that LSEC do not express the full complement of HCV receptors or entry factors and fail to support HCV replication. However, in vitro co-culture of LSEC and hepatocytes to model the hepatic epithelial-endothelial cell environment demonstrated that LSEC significantly reduce the permissivity of hepatocytes to support HCV replication. Interestingly, this effect was abrogated by inclusion of a neutralising antibody or a drug antagonist targeting VEGF receptor-2 (VEGFR-2). Importantly, recombinant VEGF had no effect on HCV replication in hepatocyte monocultures, suggesting that VEGF stimulates endothelial cells to modulate expression of molecules that regulate hepatocyte permissivity to HCV infection. Indeed, conditioned media from VEGF treated LSEC significantly reduced the ability of hepatoma cells to support HCV replication, demonstrating that LSEC modulate expression of a soluble factor that reduces HCV infectivity in response to activation via VEGFR-2.  Conclusion  In summary, these data demonstrate a new role for VEGF in endothelial-epithelial cell interactions in the liver that regulate HCV replication and highlight new areas for therapeutic intervention in chronic hepatitis C and other liver diseases.
Children's rights on entering therapeutic institutions
Authors: D Miller, R A Burt
Journal: American Journal of Psychiatry (1977)

The authors delineate aspects of adolescent psychological development that should be considered in decisions regarding psychiatric residential treatment, reviewing the issue of consent to treatment in the context of developmental psychology. They state that rather than jettisoning the whole system of placing treatable disturbed young people in residential facilities without their explicit consent, the court should take as its proper role to ensure that adolescents placed in residential psychiatric facilities receive adequate treatment.
QOS-17QUESTIONNAIRE-BASED REPORTS OF QUALITY OF SURVIVAL (QOS) AND DIRECT ASSESSMENTS OF COGNITIVE PERFORMANCE IN CHILDREN TREATED FOR MEDULLOBLASTOMA IN THE PNET 4 RANDOMIZED CONTROLLED TRIAL
Authors: Hugo Câmara-Costa, Gabriele Calaminus, Anika Resch, Virginie Kieffer, Clémence Lalande, Geraldina Poggi, Colin Kennedy, Kim Bull, Andreas Wiener, Katja von Hoff, Jacques Grill, François Doz, Stefan Rutkowski, Maura Massimino, Rolf-Dieter Kortmann, Birgitta Lannering, Georges Dellatolas, Mathilde Chevignard
Journal: Neuro-Oncology (2016)

Background: The relationship between direct assessments of cognitive performance and questionnaires assessing quality of survival (QoS) is reported to be weak-to-nonexistent. Conversely, the associations between questionnaires evaluating distinct domains of QoS tend to be strong. This pattern remains understudied.  Methods: In the HIT-SIOP PNET4 randomized controlled trial, cognitive assessments, including Full Scale, Verbal and Performance IQ, Working Memory, and Processing Speed, were undertaken in 137 survivors of standard-risk medulloblastoma from 4 European countries. QoS questionnaires, including self-reports and/or parent reports of the Behavior Rating Inventory of Executive Function (BRIEF), the Health Utilities Index, the Strengths and Difficulties Questionnaire, and the Pediatric Quality of Life Inventory, were completed for 151 survivors. Correlations among direct cognitive assessments, QoS questionnaires, and clinical data were examined in participants with both assessments available (n = 86).  Results: Correlations between direct measures of cognitive performance and QoS questionnaires were weak, except for moderate correlations between the BRIEF Metacognition Index (parent report) and working memory (r = .32) and between health status (self-report) and cognitive outcomes (r = .35–.44). Correlations among QoS questionnaires were moderate to strong both for parent and self-report (r = .39–.76). Principal Component Analysis demonstrated that questionnaires and cognitive assessments loaded on 2 separate factors.  Conclusions: We hypothesize that the strong correlations among QoS questionnaires is partially attributable to the positive/negative polarity of all questions on the questionnaires, coupled with the relative absence of disease-specific questions. These factors may be influenced by respondents’ personality and emotional characteristics, unlike direct assessments of cognitive functioning, and should be taken into account in clinical trials.
Malnutrition and obesity coexist in many countries, report finds
Authors: Anne Gulland
Journal: BMJ (2016)

Malnutrition was on the rise in nearly every country in the world and was being fuelled by obesity, a new report on global nutrition has warned.1

The report, produced by the US based International Food Policy Research Institute, looked at malnutrition in all its forms and found that 57 out of 129 countries now had high levels of both undernutrition and obesity.

It showed that rates of overweight and obesity were rising in every region of the world, and that nearly every country would miss targets on tackling the problem.

Corinna Hawkes, one of the contributors to the report and director of the Centre for Food Policy …
"Author pays" as new science publishing model
Authors: M. Richardson
Journal: BMJ (2003)

Medical staff need to be aware of major incident planningEditor-Last month the BMA warned that too few people in the United Kingdom know how to respond to a terrorist attack. 1 Its concerns about too few senior officials being aware of plans and recommendations to improve preparedness are sensible, but we believe that not enough medical staff are aware of their role in the event of a terrorist attack.We recently carried out a survey in the largest acute NHS trust of the south west of England to assess medical staff's knowledge about the local major incident plan.We sent questionnaires to the 107 doctors in North Bristol NHS Trust with a potential role in the mobile medical team if they were on duty during a major incident.Seventy seven doctors replied (72%).Sixty nine were aware of the existence of the local major incident plan, but only 26 had read part or all of it.Only 11 of the responding doctors were aware of their potential role in the mobile medical team.Of these 11 doctors, only three thought themselves adequately trained for this position, and all three had been trained as medical incident officers.Last year's National Audit Office report highlighted deficiencies in NHS plans to deal with major incidents in England. 2 It recommended upgrading training arrangements.Five months later some doctors are still unaware of their roles in the event of a terrorist attack.As a trust we are currently considering several measures to improve on our results.We suspect, however, that our findings are not unique and encourage other acute trusts to look closely at their staff's knowledge and training and act accordingly.
the Monosomal Karyotype Is an Independent Predictor of Poor Survival and Risk of AML Transformation in Patients with Myelodysplastic Syndrome
Authors: Aleksandar Savic, Dragomir Marisavljevic, Natasa Stanisavljevic, Ivana Milosevic, Vanja Zeremski, Nada Vlaisavljevic, Marina Dragicevic
Journal: Blood (2014)
RA-09THE USE OF MR SPECTROSCOPY IN INTRAOPERATIVE MR IMAGING DURING PAEDIATRIC BRAIN TUMOUR RESECTION
Authors: Shivaram Avula, Sonia Tejada, Laurence Abernethy, Carl Moon, Benedetta Pettorini, Chris Parks, Barry Pizer, Conor Mallucci
Journal: Neuro-Oncology (2016)
An Attempt to Produce Malignant Transformation of Gastric Ulcers in Rabbits; a Preliminary Report
Authors: A. C. Ivy, Almarose Cooke
Journal: JNCI Journal of the National Cancer Institute (1947)

An Attempt to Produce Malignant Transformation of Gastric Ulcers in Rabbits; a Preliminary Report Get access A. C. Ivy, A. C. Ivy Department of Physiology, Northwestern University, and University of Illinois, Chicago. Search for other works by this author on: Oxford Academic PubMed Google Scholar Almarose Cooke Almarose Cooke Department of Physiology, Northwestern University, and University of Illinois, Chicago. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 345–348, https://doi.org/10.1093/jnci/7.5.345 Published: 01 April 1947
PNR-34EVEROLIMUS TREATMENT INPATIENTS WITH TUBEROUS SCLEROSIS AND SUBEPENDYMAL GIANT CELL ASTROCYTOMAS (SEGAs) can obviate the need for surgery
Authors: Rina Dvir, Michal Manistersky, Jonathan Roth, Shlomi Constantini, Ronit Elhasid
Journal: Neuro-Oncology (2016)
<i>Still-Life With Orange</i>
Authors: Carrie A. Butt
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 1238: Effects of MLH1 on prostate cancer cell function
Authors: Shinichiro Fukuhara, Inik Chang, Yozo Mitsui, Soichiro Yamamura, Takeshi Chiyomaru, Shahana Majid, Sharanjot Saini, Hiroshi Hirata, Guoren Deng, Ankurpreet Gill, Darryn K. Wong, Hiroaki Shiina, Norio Nonomura, Rajvir Dahiya, Yuichiro Tanaka
Journal: Cancer Research (2015)

Abstract Mismatch repair (MMR) enzymes have been shown to be deficient in prostate cancer. MMR can influence the regulation of tumor development in various cancers but their role on prostate cancer has not been investigated. The aim of the present study was to determine the functional effects of the mutL-homolog 1 (MLH1) gene on growth of prostate cancer cells. The DU145 prostate cancer cell line has been previously established as MLH1-deficient and thus, this cell line was utilized to determine effects of MLH1 by gene expression. Lack of MLH1 expression was confirmed by Western blotting in DU145 cells whereas levels were high in normal prostatic PWR-1E and RWPE-1 cells. Stably expressing MLH1 in DU145 resulted in decreased cell proliferation, migration and invasion properties. Lack of cell growth using athymic nude mice model also indicated a tumor suppressive effect by MLH1. Interestingly, MLH1 caused an increase in apoptosis along with phosphorylated c-Abl, and treatment with MLH1 siRNAs countered this effect. Furthermore, inhibition of c-Abl with imatinib (STI571) also abrogated the effect on apoptosis caused by MLH1. These results demonstrate MLH1 protects against prostate cancer development by inducing c-Abl-mediated apoptosis. Citation Format: Shinichiro Fukuhara, Inik Chang, Yozo Mitsui, Soichiro Yamamura, Takeshi Chiyomaru, Shahana Majid, Sharanjot Saini, Hiroshi Hirata, Guoren Deng, Ankurpreet Gill, Darryn K. Wong, Hiroaki Shiina, Norio Nonomura, Rajvir Dahiya, Yuichiro Tanaka. Effects of MLH1 on prostate cancer cell function. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1238. doi:10.1158/1538-7445.AM2015-1238
In patients with new suspected angina, the 7-item PISA model predicted 10-year risk for coronary mortality
Authors: Anthony A. Donato
Journal: Annals of Internal Medicine (2016)

ACP Journal Club21 June 2016In patients with new suspected angina, the 7-item PISA model predicted 10-year risk for coronary mortalityAnthony A. Donato, MD, MHPEAnthony A. Donato, MD, MHPEReading Health System, Reading, Pennsylvania, USA (A.A.D.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2016-164-12-070 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSekhri N, Perel P, Clayton T, et al. A 10-year prognostic model for patients with suspected angina attending a chest pain clinic. Heart. 2016;Feb 29. [Epub ahead of print.] https://pubmed.ncbi.nlm.nih.gov/26928409Clinical Impact RatingsGIM/FP/GP: Hospitalists: Cardiology: Reference1 Jensen JM, Voss M, Hansen VB, et al. Risk stratification of patients suspected of coronary artery disease: comparison of five different models. Atherosclerosis. 2012;220:557-62. [PMID: 22189201] Google Scholar Author, Article, and Disclosure InformationAffiliations: Reading Health System, Reading, Pennsylvania, USA (A.A.D.)This article was published at Annals.org on 7 June 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 21 June 2016Volume 164, Issue 12Page: JC70KeywordsAcute coronary syndromeAnginaElectrocardiographyHeartHeart rateIschemiaMortalityRevascularizationStable coronary artery diseaseStenosis ePublished: 21 June 2016 Issue Published: 21 June 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
A case report of irritable bowel syndrome treated with doxepin
Authors: N Gartrell, D Mosbacher
Journal: American Journal of Psychiatry (1982)

The authors describe a nondepressed patient with a 10-year history of irritable bowel syndrome who became clinically asymptomatic while taking 150 mg/day of doxepin. The potential therapeutic efficacy of doxepin in the treatment of irritable bowel syndrome is discussed.
Management of diabetes mellitus in older people with comorbidities
Authors: Elbert S Huang
Journal: BMJ (2016)

Diabetes mellitus is a chronic disease of aging that affects more than 20% of people over 65. In older patients with diabetes, comorbidities are highly prevalent and their presence may alter the relative importance, effectiveness, and safety of treatments for diabetes. Randomized controlled trials have shown that intensive glucose control produces microvascular and cardiovascular benefits but typically after extended treatment periods (five to nine years) and with exposure to short term risks such as mortality (in one trial) and hypoglycemia. Decision analysis, health economics, and observational studies have helped to illustrate the importance of acknowledging life expectancy, hypoglycemia, and treatment burden when setting goals in diabetes. Guidelines recommend that physicians individualize the intensity of glucose control and treatments on the basis of the prognosis (for example, three tiers based on comorbidities and functional impairments) and preferences of individual patients. Very few studies have attempted to formally implement and study these concepts in clinical practice. To better meet the treatment needs of older patients with diabetes and comorbidities, more research is needed to determine the risks and benefits of intensifying, maintaining, or de-intensifying treatments in this population. This research effort should extend to the development and study of decision support tools as well as targeted care management.
Allergen-Induced Asthmatic Responses Modified by a GATA3-Specific DNAzyme
Authors: Norbert Krug, Jens M. Hohlfeld, Anne-Marie Kirsten, Oliver Kornmann, Kai M. Beeh, Dominik Kappeler, Stephanie Korn, Stanislav Ignatenko, Wolfgang Timmer, Cordelia Rogon, Jana Zeitvogel, Nan Zhang, Joachim Bille, Ursula Homburg, Agnieszka Turowska, Claus Bachert, Thomas Werfel, Roland Buhl, Jonas Renz, Holger Garn, Harald Renz
Journal: New England Journal of Medicine (2015)

The most prevalent phenotype of asthma is characterized by eosinophil-dominated inflammation that is driven by a type 2 helper T cell (Th2). Therapeutic targeting of GATA3, an important transcription factor of the Th2 pathway, may be beneficial. We evaluated the safety and efficacy of SB010, a novel DNA enzyme (DNAzyme) that is able to cleave and inactivate GATA3 messenger RNA (mRNA).
An Appraisal of Left and Right Breast Cancer
Authors: Lawrence Garfinkel, Leonard Craig, Herbert Seidman
Journal: JNCI Journal of the National Cancer Institute (1959)

The literature on the occurrence of left and of right breast cancer in the United States and in foreign countries is reviewed. In addition, several new series of cases from cancer registries and hospitals are reported. An analysis of the data shows that breast cancer in women occurs more often in the left breast than in the right breast. This difference is greater in foreign countries than in the United States. It is also shown that there is a smaller left/right ratio for breast cancer in women over the age of 70; that there are regional differences in the United States, by color; and that single women appear to have lower left/right ratios for breast cancer than women who are ever married. In American males, the occurrence of left breast cancer over that of right breast cancer shows a greater difference than in females. Trauma, poor milk secretion, and other factors are discussed in relation to the observed differences by side of breast.