tbuckley/cabot-search huggingface dataset:
Multimodality treatment of locally advanced penile cancer: A contemporary dosimetric comparison and case presentation.
Authors: John A. Cox, Jaipreet S. Suri, Bagi RP Jana, Eduardo Orihuela, Jared D. Sturgeon, Eugene C. Endres, Martin Colman, Todd A. Swanson
Journal: Journal of Clinical Oncology (2012)

346 Background: There is a paucity of data on the optimal therapy for locally advanced penile cancer (PC). However, advances in other HPV associated neoplasms utilizing combined modality therapy (CMT) have been encouraging. We describe the management of advanced PC with such an approach. Methods: The patient presented following partial penectomy and inguinal dissection with T 2 N 3 disease and extra-capsular extension (ECE). In a multi-disciplinary setting, it was decided to treat him post-operatively with concurrent chemoradiation. CT data sets were used for dosimetric comparison of critical structures (small bowel, rectum, bladder, scrotum, testes, bone marrow, skin, bowel, and femoral heads) and plans were generated using conventional penile fields (3D), Intensity Modulated Radiation Therapy (IMRT), and Volumetric Modulated Arc Therapy (VMAT), minimizing dose to organs at risk while optimizing treatment dose. Results: The patient was treated with IMRT (45 Gy to penile stump, pelvic and inguinal nodes (INs) with a 9 Gy boost to left INs and 15 Gy boost to right INs, due to ECE) and weekly Cisplatin (20 mg/m 2 ). IMRT gave similar coverage and avoidance of normal structures compared to VMAT but with lower mean scrotal dose ( IMRT 27.0 Gy , VMAT 29.9 Gy, 3D 45.6 Gy). There was no &gt;grade II toxicities, with grade II scrotal edema and moist desquamation of bilateral inguinal folds, not requiring treatment breaks. Acute RT toxicities had near resolution at 1 month. The IMRT and VMAT plans vs. the 3D plan had lower mean doses to the normal structures. 3D planning had unacceptable max doses to femoral head (62 Gy) and scrotum (55 Gy). Small bowel, V15Gy ≤ 150 cc was achieved by all plans. Dose homogeneity was improved for IMRT/VMAT vs. 3D planning (max dose 119%). Conclusions: This is one of the first comparisons of contemporary radiation techniques in the multimodality setting of PC. We demonstrate that utilizing IMRT concurrently with Cisplatin is feasible and well tolerated suggesting it a reasonable strategy to obtain durable local control, without which the prognosis is uniformly dismal. Larger studies are warranted to explore this contemporary CMT approach to locally advanced PC.
High Prevalence of Peripheral Artery Occlusive Disease (PAOD) Among Patients with Chronic Myeloid Leukemia (CML) Receiving Tyrosine Kinase Inhibitors (TKIs): A Cross-Sectional Study
Authors: Thanawat Rattanathammethee, Adisak Tantiworawit, Ekarat Rattarittamrong, Chatree Chai-Adisaksopha, Sasinee Hantrakool, Arintaya Phrommintikul, Siriluck Gunaparn, Lalita Norasetthada
Journal: Blood (2015)
Severe Thrombocytopenia with Impaired Megakaryocytopoiesis in a Family with von Willebrand Disease Type 2B.
Authors: Paquita Nurden, Najet Debili, William Vainchenker, Jean-Max Pasquet, Regis Bobe, Raymonde Bredoux, Alan T. Nurden, Jocelyne Enouf
Journal: Blood (2005)
Allogeneic Stem Cell Transplantation (AlloSCT) for Relapsed Hodgkin’s Lymphoma (HL) Following Autologous Stem Cell Transplantation (AuSCT): Improved Progression-Free Survival (PFS) in Patients with Graft vs Host-Disease (GvHD) Suggests a Graft vs Lymphoma (GVL) Effect.
Authors: Jessica K. Altman, Leo I. Gordon, Joanne Monreal, Andrew M. Evens, Stephanie F. Williams, Martin S. Tallman, Seema Singhal, Jayesh Mehta, Jane N. Winter
Journal: Blood (2005)
Dual Health Care System Use and High-Risk Prescribing in Patients With Dementia
Authors: Joshua M. Thorpe, Carolyn T. Thorpe, Walid F. Gellad, Chester B. Good, Joseph T. Hanlon, Maria K. Mor, John R. Pleis, Loren J. Schleiden, Courtney Harold Van Houtven
Journal: Annals of Internal Medicine (2016)

Recent federal policy changes attempt to expand veterans' access to providers outside the Department of Veterans Affairs (VA). Receipt of prescription medications across unconnected systems of care may increase the risk for unsafe prescribing, particularly in persons with dementia.To investigate the association between dual health care system use and potentially unsafe medication (PUM) prescribing.Retrospective cohort study.National VA outpatient care facilities in 2010.75 829 veterans with dementia who were continuously enrolled in Medicare from 2007 to 2010; 80% were VA-only users, and 20% were VA-Medicare Part D (dual) users.Augmented inverse propensity weighting was used to estimate the effect of dual-system versus VA-only prescribing on 4 indicators of PUM prescribing in 2010: any exposure to Healthcare Effectiveness Data and Information Set (HEDIS) high-risk medication in older adults (PUM-HEDIS), any daily exposure to prescriptions with a cumulative Anticholinergic Cognitive Burden (ACB) score of 3 or higher (PUM-ACB), any antipsychotic prescription (PUM-antipsychotic), and any PUM exposure (any-PUM). The annual number of days of each PUM exposure was also examined.Compared with VA-only users, dual users had more than double the odds of exposure to any-PUM (odds ratio [OR], 2.2 [95% CI, 2.2 to 2.3]), PUM-HEDIS (OR, 2.4 [CI, 2.2 to 2.8]), and PUM-ACB (OR, 2.1 [CI, 2.0 to 2.2]). The odds of PUM-antipsychotic exposure were also greater in dual users (OR, 1.5 [CI, 1.4 to 1.6]). Dual users had an adjusted average of 44.1 additional days of any-PUM exposure (CI, 37.2 to 45.0 days).Observational study design of veteran outpatients only.Among veterans with dementia, rates of PUM prescribing are significantly higher among dual-system users than with VA-only users.U.S. Department of Veterans Affairs.
The relationship between disease severity and quality of life in discoid lupus erythematosus
Authors: H. Gordon, A. Chandran, A.C. Vandal, A. Yung, P. Jarrett
Journal: British Journal of Dermatology (2016)

Conflicts of interest: none declared. Dear Editor, Discoid lupus erythematosus (DLE) is a chronic scarring skin condition and a subset of cutaneous lupus as defined by Gilliam and Sontheimer.1 It is a common form of cutaneous lupus erythematosus in a European population.2 The objective of this study was to assess the effect of DLE severity on quality of life. Quality of life was measured by the patient using the Dermatology Life Quality Index (DLQI) and was correlated with the severity of their disease objectively assessed by the Cutaneous Lupus Disease Area and Severity Index (CLASI). CLASI is a validated tool that enables physicians to assign a score to the severity of cutaneous lupus.3 An activity score is calculated from the degree and area of erythema, scale and hypertrophy, mucous membrane involvement and alopecia. A damage score is calculated from the dyspigmentation and scarring seen. The DLQI is a validated measure of quality of life with a maximum score of 30, with increasing score indicating an increasing impact on quality of life.4 Additionally, Māori and Pacific Island patients were examined as a combined specific subgroup, as in New Zealand, Māori and Pacific Island patients are at particular risk of DLE, with an age‐ and sex‐adjusted relative risk of 5·96 [95% confidence interval (CI) 3·06–11·6] compared with European New Zealanders.5
Sociodemographic and clinical characteristics among men with metastatic prostate cancer: An aged-stratified analysis.
Authors: Jamie Forlenza, Mekre Senbetta, Amy Smalarz, Kimberly Riggs
Journal: Journal of Clinical Oncology (2012)

256 Background: Data on age-specific comparisons in metastatic prostate cancer (MPC) is limited. This analysis evaluated socio-demographic and clinical characteristics among men with MPC aged &lt;65 years versus ≥65 years. Methods: Eighty-four US men aged ≥18 years with self-reported MPC completed a cross-sectional survey in January-February 2011 which collected data on socio-demographic and clinical characteristics including treatment history and source of care. Results: Forty-nine men were aged &lt;65 years; 35 men were ≥65 years. There were no differences (all P&gt;0.05) between groups for marital status (80% of those &lt;65 years and 83% of those ≥65 years were married), race/ethnicity (94% of both groups were white), education (88% of those &lt;65 years and 77% of those ≥65 years had attended college), and annual household income (29% of those &lt;65 years and 31% of those ≥65 years had incomes of $35,000-$54,999). Time since diagnosis differed between groups with 12%, 84%, and 4% of those aged &lt;65 years and 3%, 69%, and 29% of those aged ≥65 years having been diagnosed &lt;1, 1-9, and ≥10 year(s) ago, respectively (P&lt;0.001). Respondents aged &lt;65 years and ≥65 years reported similar experience with chemotherapy (37% in both groups had received chemotherapy), no anemia in last 4 weeks (80% and 83%, respectively), no bone fractures or spinal cord compression in last 4 weeks (90% and 94%, respectively), receiving previous radiation therapy (69% and 66%, respectively), receiving previous surgery (63% and 66%, respectively), and utilizing hormonal treatments previously or currently (86% and 90%, respectively) (all P&gt;0.05). In addition, those &lt;65 years versus ≥65 years did not differ regarding their self-reported source of primary care for prostate cancer (51% and 54% reported receiving their care from oncologists, respectively; 47% and 43% from urologists; 2% and 3% from family physicians/internists). Conclusions: In this study of men with MPC, those aged &lt;65 years and those ≥65 years reported similar prostate cancer treatment utilization as well as socio-demographic and clinical characteristics with the exception of a difference in time since diagnosis. Further research in larger populations is warranted.
Low Levels of Global (LINE) and CDH13 Methylation at Diagnosis and Rapid Clearance of Marrow Blasts Correlate with A Better Haematological Response to Azacitidine in Patients with Newly Diagnosed and Refractory/Relapsed AML Not Eligible for or Resistant to Chemotherapy: A Multi-Centre Phase I/II-Study of the East German Haematology and Oncology Study Group (OSHO).
Authors: Michael Cross, Nadja Jaekel, Rainer Krahl, Christian Junghanss, Georg Maschmeyer, Thao Tran, Gisa Hoppe, Dietger Niederwieser, Haifa Kathrin Al-Ali
Journal: Blood (2009)
An international perspective: The role of nurse involvement in improving breast cancer control.
Authors: B. M. Blauvelt, S. K. Podder, O. Abulkhair, C. H. Barrios, C. Huang, S. Kim, L. D. Shockney
Journal: Journal of Clinical Oncology (2011)

152 Background: Non-Western, non-Caucasian populations comprise 90% of the world’s estimated 3.2 billion women, living mostly in low and middle income nations. While medical advances have greatly reduced breast cancer morbidity and mortality in developed nations, those are on the rise in many low and middle income nations. The purpose of the study was to identify emerging needs and challenges observed by breast cancer thought leaders in diverse regions of the world consisting mainly of lesser developed nations to identify strategies for improving breast cancer control. Methods: 225 breast cancer medical, advocacy and policy leaders from 30 countries in Latin America, Asia, the Middle East/North and South Africa, Canada and Australia participated in this study. The study sample was composed of 203 breast cancer specialists, 12 patient advocates and 10 policy makers. Results: The most salient needs and challenges identified were to: (1) develop nurses trained in breast cancer patient and family care, management, education and clinical research (48%); (2) individualize breast cancer therapy (47%); and (3) improve understanding of the reasons for apparently higher proportions of younger women presenting with more aggressive tumors among these predominantly non-Caucasian populations (45%). Analysis of these and other needs identified evolved into 4 key themes and sub-dimensions involving nurses to improve breast cancer control: Capacity, Research, Advocacy and Access. Conclusions: The most significant need identified by this study was to increase both the capacity and capability of breast cancer nurses. A comprehensive approach to doing this would include: (1) increasing capacity to educate nurses in breast cancer patient education and related care issues in nursing schools and teaching hospitals; (2) working with local medical societies, educational institutions and governmental authorities to enable nurses to work as primary care practitioners; and (3) increasing participation of nurses in breast cancer clinical research, working with clinicians and in collaboration with breast cancer research centers of excellence from around the world.
Comparative Analysis of Matched Related Donor (MRD) and Matched Unrelated Donor (MUD) Hematopoietic Stem Cell Transplantation in Treatment of Patients with Chronic Myeloid Leukemia.
Authors: Jan Styczynski, Lidia Gil, Jan Maciej Zaucha, Anna Czyz, Maria Bieniaszewska, Mariusz Wysocki, Andrzej Hellmann, Mieczyslaw Komarnicki
Journal: Blood (2006)
Hydroxyurea for the Prevention of Stroke and Other Vasoocclusive Complications in Children with Sickle Cell Disease.
Authors: Markus Schmugge, Karin Zurbriggen, Manuela Albisetti, Marlies Schmid, Ralf W. Baumgartner, Roman Sztajzel, Gabriel Martin, Hulya Ozsahin
Journal: Blood (2005)
Predictions for positive nodes in breast cancer using computerized modeling.
Authors: U. Gawlick, K. Hewitt, P. Tamayo, M. C. Mone, H. J. Hansen, E. W. Nelson
Journal: Journal of Clinical Oncology (2011)

16 Background: The accuracy and consistency of sentinel lymph node (SLN) biopsy for axillary staging in breast cancer has been well established by multiple studies. Although the standard of care has been to perform a completion axillary lymph node dissection (ALND) on patients who have a positive sentinel node, recent data (ACOSG Z0010, Z0011 and NSABP B-32) suggests that an ALND may be avoided in certain subsets of patients. To further study this question, we used a Bayesian model to predict the probability of finding disease in the ALND for breast cancer. Methods: All SLN procedures performed by a single surgeon, for clinical T1-T2 N0 disease between September 2000 and March 2009 were retrospectively reviewed under an IRB approved protocol. Demographic, disease and surgical procedural variables were collected. Values are reported as mean ± standard deviation. A Bayesian model, a standard statistical model frequently used in medicine, was used to identify variables that could predict a positive ALND. Results: A total number of 235 SLN procedures were reviewed. The mean patient age was 58.6 ± 11.8 (range 28-88), tumor size was 1.8 ± 1.3 cm (range 0.2-7.4), and BMI was 28 ± 6.1. The number of SLN found was 3.6 ± 1.9 (range 0-10), and in 2 cases no SLN were found, for an overall failure rate of 0.85%. A total of 73 ALND were performed in this group; 27 cases had ALND as national study participants randomized to ALND, 44 cases for positive SLN, and 2 cases in which no SLN could be identified. The mean number of axillary lymph nodes removed was 14.8 ± 7 and the mean number of positive axillary nodes was 2.7 ± 4.1. Tumor size, tumor grade, number of positive SLN by hematoxylin and eosin staining, and a low technetium count of the first SLN were found to be significant predictors of positive axillary nodes during a completion ALND. There was also a trend for progesterone receptor expression as a predictor of axillary disease. Conclusions: A model to predict a positive ALND for breast cancer is presented. We found tumor characteristics, number of positive SLN and low technetium count for first SLN to be predictors for finding axillary disease. Further studies are needed to validate our model as a means of sparing women an ALND who have a low probability of finding additional breast disease.
Improved Homing To Bone Marrow, Spleen and Lung Of Adoptively Infused NK Cells Expanded Ex Vivo With The Small Molecule Nicotinamide Using Feeder-Free Conditions
Authors: Gabi M. Frei, Maria Berg, Tony Peled, Robert N. Reger, Ritesh Kotecha, Toshihiro Onishi, Luis Espinoza-Calderon, Nurit Persi, Chana Lador, Amnon Peled, Richard W. Childs
Journal: Blood (2013)
PS01.66: Biomarker Stratification of Outcomes of Third-Generation EGFR TKI Therapy in Patients with Previously-Treated Advanced NSCLC
Authors: Heather Wakelee, Jonathan W. Goldman, Shirish Gadgeel, David R. Camidge, Karen L. Reckamp, Sai-Hong I. Ou, Helena A. Yu, Benjamin Solomon, Stephen V. Liu, Maurice Pérol, Nicholas F. Dupuis, Alex Nickel, Chris Karlovich, Mitch Raponi, Sergey Yurasov, Jason Litten, Darrin Despain, Jean-Charles Soria, Lecia Sequist, David Carbone
Journal: Journal of Thoracic Oncology (2016)
Retrospective cohort study on the risk factors of admission due to serious adverse events during S-1 (tegaful, gimeracil, oteracil potassium) containing chemotherapy for gastric cancer.
Authors: Yasuyuki Kawamoto, Satoshi Yuki, Yoshimitsu Kobayashi, Koji Oba, Hideyuki Hayashi, Hiroshi Nakatsumi, Yoshito Komatsu
Journal: Journal of Clinical Oncology (2012)

141 Background: S-1 (tegaful, gimeracil, oteracil potassium) containing regimens are widely used as first line chemotherapy for metastatic or unresectable gastric cancer in Japan. Because patients often need admission due to serious adverse events (SAE) during chemotherapy, it is important to predict admission. We retrospectively investigated the risk factors of admission due to SAE during first line chemotherapy which contained S-1. Methods: We retrospectively analyzed the patients who began to receive S-1 containing chemotherapy for the first line chemotherapy at our institution from January 2005 to December 2010 by medical records. Association between baseline characteristics and admission due to SAE were evaluated by Fisher’s exact test, t-test or Mann-Whitney test. Age, sex, S-1 dose (mg/m 2 ) and other factors which significantly associated in the univariate analysis were evaluated in the multivariate logistic regression model. Results: One hundred nine patients were assessed. Admission due to SAE were observed in 24 patients (34 times), and tended to occur before 2nd cycle had ended. Multivariate analysis suggested that hypoalbuminemia was a risk factor of admission due to all SAE (Odds ratio 0.15, 95% C.I. 0.05 - 0.44, P = 0.0005). It is suggested that S-1 dose was a risk for admission due to FU-induced colitis (Odds ratio 1.30, 95% C.I. 1.12 - 1.50, P=0.0004). Conclusions: Hypoalbuminemia might constitute a marker of admission due to SAE. FU-induced colitis occurred in S-1 dose-related fashion, and the patients had lost their weight before appropriate course. It is suggested that clinicians should pay attention to patients’ weight loss during chemotherapy, notably time of initiation of chemotherapy.
Oral Mucositis (OM) and Outcomes of Autologous (AU) Hematopoietic Stem Cell Transplantation (HSCT) Following High-Dose Melphalan (MP) Conditioning for Multiple Myeloma (MM).
Authors: Gerry Oster, Montserrat Vera-Llonch, Colleen Ford, John Lu, Irina Khazanov, Stephen Sonis
Journal: Blood (2005)
Bariatric Surgery and the Risk of New-Onset Atrial Fibrillation in Swedish Obese Subjects
Authors: Shabbar Jamaly, Lena Carlsson, Markku Peltonen, Peter Jacobson, Lars Sjöström, Kristjan Karason
Journal: Journal of the American College of Cardiology (2016)

Obesity is a risk factor for atrial fibrillation, which in turn is associated with stroke, heart failure, and increased all-cause mortality. The authors investigated whether weight loss through bariatric surgery may reduce the risk of new-onset atrial fibrillation. SOS (Swedish Obese Subjects) is a prospective matched cohort study conducted at 25 surgical departments and 480 primary healthcare centers in Sweden. The cohort was recruited between 1987 and 2001. Among 4,021 obese individuals with sinus rhythm and no history of atrial fibrillation, 2,000 underwent bariatric surgery (surgery group), and 2,021 matched obese control subjects received usual care (control group). The outcome, first-time atrial fibrillation, was ascertained by crosschecking the SOS database with the Swedish National Patient Register on inpatient and outpatient diagnosis codes. During a median follow-up of 19 years, first time atrial fibrillation occurred in 247 patients (12.4%) in the surgical group, and in 340 (16.8%) control subjects. The risk of developing atrial fibrillation was 29% lower in the surgery group versus the control group (hazard ratio: 0.71; 95% confidence interval: 0.60 to 0.83; p < 0.001). Younger individuals benefited more from surgical intervention than those who were older (p value for interaction 0.001). Also, those with a high diastolic blood pressure benefitted more from surgery than did those with a low diastolic blood pressure (p for interaction = 0.028). Compared with usual care, weight loss through bariatric surgery reduced the risk of atrial fibrillation among persons being treated for severe obesity. The risk reduction was more apparent in younger people and in those with higher blood pressure.
A Statement on Ethics From the HEART Group
Journal: Circulation Research (2008)

Over the past several years, the editors of leading international cardiovascular journals have met to form the HEART group and to discuss areas of growing, common interest. Recently, the HEART group has developed a document that addresses general ethical principles in the conduct of the scientific process with which all of the editors concur. Published essentially simultaneously in all of the participating journals, including this journal, this document presents the ethical tenets accepted by all of the undersigned editors that will (continue to) guide their decisions in the editorial process.

These are the general principles on which the HEART Group is based and by which we, as a group, abide; however, please note that individual journal members and their respective societies may have their own rules and regulations that supersede the guidelines of the HEART Group.

### Acta Cardiologica

Hugo Ector, MD, PhD

Editor-in-Chief

Patrizio Lancellotti, …
Clinical Benefit and Costs’ Evaluation of Erythocytapheresis Compared to Manual Exchange Transfusion for Children with Sickle Cell Disease: A Single Center Experience
Authors: Laurence Dedeken, Phu Quoc Lê, Laurence Rozen, Hanane El Kenz, Sophie Huybrechts, Christine Devalck, Delphine Sauvage, Catherine Heijmans, Alina Ferster
Journal: Blood (2014)