tbuckley/cabot-search huggingface dataset:
Contribution of BRCA1 and BRCA2 mutations to breast cancer in Tunisia
Authors: T. Wafa
Journal: Journal of Clinical Oncology (2009)

e22191 Background: Hereditary breast cancer accounts for 3–8% of all breast cancers. It was recently estimated that a combination of BRCA1 and BRCA2 genes mutations is responsible for 30% of hereditary breast cancer cases. Methods: To investigate the prevalence of BRCA1 and BRCA2 gene mutations in breast cancer patients with affected relatives in Tunisia, 36 patients who had at least one first degree relative affected with breast and/or ovarian cancer were analysed. Thirty three patients are suggestive of BRCA1 mutation and 3 are suggestive of BRCA2 mutation. Results: Four mutations in BRCA1 gene were described among which, one novel splice site mutation (330 dupA) and 3 frameshift mutations including the 4160 delAG, the 2789 delG and the 5385 insC. Our study is the first to describe the 5385 insC mutation which was described only among Jewish Ashkenazi population. Two frameshift mutations (1537 del4 and 5909 insA) were screened in BRCA2 gene. Nineteen percent (7/36) of the familial cases were altered on BRCA1 or BRCA2 genes with deleterious mutations at heterozygous state and 55% (20/36) by mutation with uncertain value (UV) or by single nucleotide polymorphisms (SNPs). Conclusions: Almost all the cases mutated by deleterious mutations on BRCA1 gene reported a family history of breast and/or ovarian cancer in the index case or in their relatives. On the contrary, patients with an UV mutation or SNPs have no history of ovarian cancer in their corresponding families. Our data are the first to contribute to information on mutation spectrum of BRCA genes and offer a recommended screening mode for clinical genetic testing policy in Tunisia. No significant financial relationships to disclose.
USE OF TRIETHYLENE MELAMINE IN TREATMENT OF LEUKEMIA AND LEUKOSARCOMA
Authors: J H SILVERBERG, W DAMESHEK
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Quantification of Intratumoral Metabolic Macroheterogeneity on 18F-FDG PET/CT and Its Prognostic Significance in Pathologic N0 Squamous Cell Lung Carcinoma
Authors: Do-Hoon Kim, Ji-hoon Jung, Seung Hyun Son, Choon-Young Kim, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Journal: Clinical Nuclear Medicine (2015)

Purpose This study aimed to develop a novel quantification method for intratumoral metabolic macroheterogeneity (IMMH) on 18F-FDG PET/CT and evaluate its prognostic significance in pathologic N0 (pN0) squamous cell lung carcinoma (SQCLC) patients. Patients and Methods A total of 83 patients who underwent pretreatment 18F-FDG PET/CT and were diagnosed with pN0 SQCLC after curative surgery were examined. Patients with tumor measuring greater than 2 cm were included. Metabolic parameters (SUVmax, metabolic tumor volume, and total lesion glycolysis) for the primary lesions were calculated on the 18F-FDG PET/CT, and IMMH was quantified as the macroheterogeneity factor (MHF), defined as surface/spherical surface area having volume of the primary tumor multiplied by the sphericity. Heterogeneity of the primary tumor was also visually assessed (visual heterogeneity score) and compared with MHF. Univariate and multivariate analyses for recurrence were performed using the Cox proportional hazards regression. Results Recurrence was observed in 27 (32.5%) of 83 patients during follow-up period (37.6 ± 25.5 months). Significant correlations were observed between the visual heterogeneity score and the MHF (R = 0.534, P < 0.001). Macroheterogeneity factor was significantly higher in patients who experienced recurrence (median, 1.073 vs 1.016; P = 0.004). Univariate analysis showed that MHF was only significant prognostic factor for recurrence (P = 0.019), and multivariate analysis after adjusting for age, sex, tumor size, histologic grade, and pathologic T stage, high MHF exhibited an association with increased risk of recurrence. Conclusions New quantification method for IMMH on 18F-FDG PET/CT was developed, and the heterogeneity parameter MHF was well correlated with visual heterogeneity. Macroheterogeneity factor on pretreatment 18F-FDG PET/CT was the sole prognostic factor predicting recurrence in pN0 SQCLC patients.
SBH-1, a novel Reed-Sternberg-like cell line capable of inducing tumors in SCID mice: immunophenotypic, cytogenetic, and cytokine expression profiles
Authors: JF DeCoteau, MD Reis, H Griesser, A Lorenzana, I al-Hashmi, RG Hawley, A Naumov, CA White, PH Pinkerton
Journal: Blood (1995)
Different definitions of alcoholism, II: A pilot study of 10 definitions in a treatment setting
Authors: J H Boyd, K Derr, B Grossman, C Lee, S Sturgeon, D D Lacock, C I Bruder
Journal: American Journal of Psychiatry (1983)

The authors have developed the Alcohol Poly-Diagnostic Interview, which permits the operationalization of the 10 leading definitions of alcoholism used in the United States and Europe. In a pilot study of 23 patients in an outpatient alcohol treatment facility, all patients were identified as alcoholic by seven of the diagnostic schemes; the other three diagnostic schemes identified at least 78% of the patients as alcoholic. The authors also found that the Diagnostic Interview Schedule was sensitive to the diagnosis of alcoholism among treated patients. This approach should facilitate further research into the relationship among various definitions of alcoholism and studies of their validity.
Effectiveness of the 2009 seasonal influenza vaccine against pandemic influenza A(H1N1)2009 in healthcare workers in New Zealand, June-August 2009
Authors: S Jefferies, D Earl, N Berry, T Blackmore, S Rooker, N Raymond, A Pritchard, M Weatherall, R Beasley, K Perrin
Journal: Eurosurveillance (2011)

There is uncertainty whether the 2009 seasonal influenza vaccination influences the risk of infection with the 2009 pandemic influenza A(H1N1) virus. This issue was investigated in 548 healthcare workers from Capital and Coast District Health Board, Wellington, New Zealand, presenting with influenza-like illness during the influenza pandemic between June and August 2009. All workers completed an assessment sheet and had a nasopharyngeal swab tested by real-time RT-PCR. The risk of pandemic influenza A(H1N1) infection associated with the 2009 seasonal inactivated trivalent influenza vaccine was determined by logistic regression, with adjustment for potential confounding variables. In 96 workers pandemic influenza A(H1N1) RNA was detected and 452 tested negative. The multivariate analysis did not show any effect of vaccination on PCR-confirmed influenza A(H1N1)2009 infection (odds ratio 1.2, 95% confidence interval 0.7–1.9, p=0.48). We conclude that 2009 seasonal influenza vaccination had no protective effect against influenza A(H1N1)2009 infection amongst healthcare workers. To protect against further waves of the current pandemic influenza or future pandemics in which the influenza virus is antigenically distinct from contemporary seasonal influenza viruses, it would be necessary to vaccinate with a specific pandemic influenza vaccine, or a seasonal influenza vaccine that includes the pandemic influenza serotype.
Antimicrobial drug resistance in isolates of Salmonella enterica from cases of salmonellosis in humans in Europe in 2000: results of international multi-centre surveillance
Authors: E J Threlfall, I. S.T. Fisher, C Berghold, P Gerner-Smidt, H Tschäpe, M Cormican, L Luzzi, F Schneider, W J B Wannet, J Machado, G Edwards
Journal: Eurosurveillance (2003)

The Enter-net surveillance system received results of antimicrobial sensitivity tests for isolates from over 27 000 cases of human salmonellosis in 2000 in 10 European countries. Almost 40% of isolates were resistant to at least one antimicrobial, with 18% multiresistant. Resistance to ampicillin, streptomycin, sulphonamides and tetracyclines was common, with over 20% of isolates resistant to at least one of these antimicrobials. Clinical resistance to ciprofloxacin was rare, with only 0.5% of isolates exhibiting such resistance (MIC &amp;gt;1.0 mg/l). Resistance to nalidixic acid coupled with a decreased susceptibility to ciprofloxacin (MIC 0.25-1.0 mg/l) was more common, with 14% of isolates showing these properties. Resistance to third-generation cephalosporins was rare with only 0.6% of isolates resistant to cefotaxime. In all countries multiple resistance was most common in Salmonella enterica serotype Typhimurium, with 51% of isolates multiresistant in total. In England and Wales multiple resistance was also prevalent in S. Virchow and S. Hadar, whereas in other countries multiple resistance was common in serotypes such as S. Blockley.
Neoplastic Transformation of Granulosa Cells in Grafts of Normal Ovaries into Spleens of Gonadectomized Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: J. Furth, H. Sobel
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Neoplastic Transformation of Granulosa Cells in Grafts of Normal Ovaries into Spleens of Gonadectomized Mice Get access J. Furth, J. Furth professor of pathology Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Sobel H. Sobel research fellow, the David, Josephine, and Winfield Baird Foundation Department of Pathology, Cornell University Medical College Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 1, August 1947, Pages 7–16, https://doi.org/10.1093/jnci/8.1.7 Published: 01 August 1947 Article history Received: 17 March 1947 Published: 01 August 1947
HSV-2 Suppression and the Incidence of HIV
Authors: Andrea Lisco, Christophe Vanpouille
Journal: New England Journal of Medicine (2008)

Dr. Ross raises the very valuable point that patients with cardiac arrest who are far from emergency medical services may be at elevated risk, as compared with those living in a city.As such, the availability of an AED in the home might have particular value for a patient living in a rural area or in an area where emergency services are suboptimal.In our study, the number of events was too low to address this question in a definitive manner, but we can say that the rescue of patients with cardiac arrest by spouses certainly did occur in rural settings and far from medical aid.It is unlikely these patients would have survived ventricular fibrillation without an AED.
Fatherhood and emotional illness
Authors: J O Cavenar, N T Butts
Journal: American Journal of Psychiatry (1977)

The authors describe four cases in which men developed emotional illnesses related to their wives' pregnancies. In all of the cases, the patients had experienced sibling rivalry at a significant time in their lives. This factor seemed to be more important dynamically in understanding their feelings about fatherhood than previously proposed factors, such as envy of the wife's childbearing capacity, dependence on the wife, and neurotic conflict with the oedipal father. The authors suggest that in men with neuroses, the issue of sibling rivalry is an important determinant of reactions to fatherhood.
NGS-Based Detection Of Multiple RAS-Mutated Clones In MLL-Rearranged Leukemias Suggests Strong Oncogenic Collaboration
Authors: Vincent-Philippe Lavallée, Patrick Gendron, Geneviève Boucher, Marianne Arteau, Brian T Wilhelm, Sébastien Lemieux, Josée Hébert, Guy Sauvageau
Journal: Blood (2013)
THE ETIOLOGY OF HEART FAILURE
Authors: B E Strauer
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 27-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Alan D. Hilgenberg, Eugene J. Mark
Journal: New England Journal of Medicine (1987)

Presentation of Case First admission. A 53-year-old man was admitted to the hospital because of multiple bilateral pulmonary-nodules.He was well until three years earlier, when symptoms of a respiratory tract infection were followed by a chronic nonproductive cough. Two months before admission he began to cough up blood-tinged sputum. Subsequently, an x-ray film of the chest showed scattered bilateral pulmonary nodules, less than 10 mm in diameter, without intrinsic calcification. An intravenous urographic examination, a barium-enema examination, and an upper gastrointestinal study were negative, and cytologic examination of sputum was negative for tumor cells. He was referred to this . . .
Jejunoduodenal Fistula due to Penetrating Peptic Ulcer after Roux-en-Y Hepaticojejunostomy
Authors: G.  C.  Sotiropoulos, K.  J.  Oldhafer, N.  R.  Frühauf, U.  Treichel, U.  A.  Clauer, E.  I.  Brokalaki, C.  E . Broelsch
Journal: Endoscopy (2003)

Biliary-enteric communications between the gallbladder and duodenum, or between the common bile duct and the duodenum, are infrequently reported. They are mainly caused by perforation of gallstones into an otherwise normal duodenum, or by peptic ulceration from the duodenum into the biliary tree, respectively [1] [2]. Iatrogenic fistulas resulting from the passage of bougies or dilators into the duodenum during exploration of the common bile duct have also been mentioned in the literature [3]. A 55-year-old man underwent hilar liver resection with left hepatectomy and Roux-en-Y hepaticojejunostomy for a Klatskin cholangiocarcinoma. Intraoperatively, the duodenum appeared normal. Uncommon postoperative epigastric symptoms led to a gastroduodenal endoscopy examination and diagnosis of a duodenal ulcer. The ulcer was attributed to Helicobacter pylori infection. Eradication therapy was carried out following the Italian schema. The patient was finally discharged on postoperative day 15. Two months later, the patient returned, with epigastric pain and signs of cholangitis. A gastroduodenal endoscopy examination raised a suspicion of a jejunoduodenal fistula between the proximal duodenum and the Roux limb, probably caused by penetration of the peptic ulcer (Figures [1], [2]). The patient received therapy with ciprofloxacin, ursodeoxycholic acid, and omeprazole. A 6-week period of endoscopic observation showed that the peptic lesion was healing. However, the fistula persisted, with the patient having symptoms of relapsing ascending cholangitis. The duodenal lesion and fistula were therefore finally excised, and direct closure of the fistula opening on the duodenal wall was carried out. At the time of writing, a year after the last operation, the patient is living normally and is free of symptoms. In view of the numbers of Roux-en-Y reconstructions carried out in digestive tract surgery worldwide [4], the masked clinical presentation of the fistula in the present case should be noted in order to facilitate the differential diagnosis in cases of unexplained postoperative epigastric pain associated with cholangitis. Despite an extensive literature search, no previous reports of a jejunoduodenal fistula after Roux-en-Y reconstruction have been identified.
FRI0606 In Vivo Imaging of Phagocyte Migration in Inflammatory Processes by Fluorescent Cell Tracking
Authors: S. Gran, M. Schäfers, J. Roth, T. Vogl
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Activation, recruitment and migration of phagocytes into infected or inflamed tissue are the very first and crucial events occurring in the onset of an inflammation. The most abundant calcium-binding proteins in phagocytes that are involved in cytoskeletal-membrane interactions during adherence and migration are complexes of S100A8/S100A9. Expression of these proteins, however, shows also a close correlation to disease activity in inflammatory disorders - amongst a broad range of acute as well as chronic disorders especially in rheumatoid arthritis. <h3>Objectives</h3> The aim of this study was to analyze S100A8/A9 affected pathways involved in phagocyte migration under inflammatory conditions <i>in vivo</i> by optical imaging of fluorescently labeled cells. <h3>Methods</h3> Immortalized murine myeloid progenitor ER-HoxB8 cells obtained from wildtype as well as S100A8/S100A9<sup>-/-</sup> mice were differentiated to neutrophils or monocytes/macrophages<sup>1</sup>. Cells were labeled with the membrane-selective fluorescent dyes DIR, DID and VivoTrack680 (IVT), respectively<sup>2</sup>. We analyzed viability and functionality of stained cells <i>in vitro</i> and investigated their ability to migrate to sites of inflammation <i>in vivo</i> in a dermatitis mouse model via fluorescence reflectance imaging (FRI). <h3>Results</h3> ER-HoxB8 cells could be effectively stained with all three fluorescent dyes. Labeling of monocytes/ macrophages or neutrophils with DIR, DID or VivoTrack680 did not affect viability or cellular functions like adhesion, migration, phagocytosis or ROS production <i>in vitro</i>. Furthermore, FRI allowed the visualization of migrated phagocytes in a toxic contact dermatitis mouse model <i>in vivo</i>. Both, cells of monocytic and neutrophilic origin - with neutrophils revealing faster migration kinetics - each could be detected at sites of inflammation with high sensitivity. Differential cell labeling allowed direct quantitative comparison of differences in recruitment of wildtype and S100A8/S100A9<sup>-/-</sup> neutrophils and monocytes <i>in vivo</i>. <h3>Conclusions</h3> Specific and distinguishable labeling of diverse cell types obtained from different mouse lines allows non-invasive tracking and subsequent quantification of migrated cells within the same animal <i>in vivo</i>. Further steps will now focus on analysis and quantification of cellular recruitment – particularly S100A8/S100A9 affected cell migration – during arthritis/in an arthritis mouse model. <h3>References</h3> Wang, G. G. et al. Quantitative production of macrophages or neutrophils ex vivo using conditional Hoxb8. Nat. Methods 3, 287–293 (2006). Eisenblätter, M. et al. In vivo optical imaging of cellular inflammatory response in granuloma formation using fluorescence-labeled macrophages. J. Nucl. Med. 50, 1676–1682 (2009). <h3>Disclosure of Interest</h3> None declared
The Oncomine Cancer Research Panel, a scalable next-generation sequencing system for relevant somatic variant assessment in solid tumors.
Authors: Daniel H. Hovelson, Andi K. Cani, Andrew McDaniel, Bryan Johnson, Kate Rhodes, Paul D Williams, Santhoshi Bandla, Paul Choppa, Fiona Hyland, Guoying Liu, Jeoffrey Schageman, Venkata Yadati, Anmol Amin, Kathleen A. Cooney, Felix Yi-Chung Feng, Chia-Jen Liu, Arul M. Chinnaiyan, Seth Sadis, Dan Rhodes, Scott A. Tomlins
Journal: Journal of Clinical Oncology (2015)

e22164 Background: Next generation sequencing (NGS) has enabled genomewide personalized oncology efforts at centers and companies with the specialty expertise and infrastructure required for actionable variant identification and prioritization. Such approaches are not scalable, precluding widespread adoption. Methods: We conducted a comprehensive bioinformatics analysis and developed a knowledgebase of approved and investigational therapies to predefine the catalog of relevant solid tumor somatic genome variants (gain or loss of function mutations, high level copy number alterations, and gene fusions). To identify these variants, we developed the Oncomine Cancer Research Panel (OCP), which consists of amplicon based panels and an informatics pipeline for Ion Torrent NGS. OCP performance was assessed using molecular standards and formalin fixed paraffin embedded (FFPE) tumors. Results: Through integrating an analysis of over 700,000 cancer samples and a therapeutic knowledgebase, we designed the OCP, an Ion Torrent based NGS system compatible with < 20ng FFPE tissue isolated DNA/RNA. OCP validation using two different molecular standards demonstrated > 99% detection rate for known mutations (at near-expected variant frequencies). OCP assessment of over 300 FFPE tumor samples demonstrated > 95% sensitivity and specificity for KRAS, EGFR and BRAF mutation detection, as well as for ALK and TMPRSS2:ERGgene fusions. Associating positive variants with potential targeted treatments demonstrated that 642% of profiled tumor samples (depending on cancer type) harbored alterations beyond routine molecular testing that were associated with FDA approved or NCCN guideline-referenced therapies. Conclusions: By predefining somatic variants in solid tumors and compiling associated potential treatments and clinical trials, the OCP represents a simplified, broadly applicable targeted NGS system with the potential to advance precision oncology efforts.