tbuckley/cabot-search huggingface dataset:
Novel Type of Renal Amyloidosis Derived from Apolipoprotein-CII
Authors: Samih H. Nasr, Surendra Dasari, Linda Hasadsri, Jason D. Theis, Julie A. Vrana, Morie A. Gertz, Prasuna Muppa, Michael T. Zimmermann, Karen L. Grogg, Angela Dispenzieri, Sanjeev Sethi, W. Edward Highsmith, Giampaolo Merlini, Nelson Leung, Paul J. Kurtin
Journal: Journal of the American Society of Nephrology (2016)

Amyloidosis is characterized by extracellular deposition of misfolded proteins as insoluble fibrils. Most renal amyloidosis cases are Ig light chain, AA, or leukocyte chemotactic factor 2 amyloidosis, but rare hereditary forms can also involve the kidneys. Here, we describe the case of a 61-year-old woman who presented with nephrotic syndrome and renal impairment. Examination of the renal biopsy specimen revealed amyloidosis with predominant involvement of glomeruli and medullary interstitium. Proteomic analysis of Congo red–positive deposits detected large amounts of the Apo-CII protein. DNA sequencing of the APOC2 gene in the patient and one of her children detected a heterozygous c.206A→T transition, causing an E69V missense mutation. We also detected the mutant peptide in the proband’s renal amyloid deposits. Using proteomics, we identified seven additional elderly patients with Apo-CII–rich amyloid deposits, all of whom had kidney involvement and histologically exhibited nodular glomerular involvement. Although prior in vitro studies have shown that Apo-CII can form amyloid fibrils and that certain mutations in this protein promote amyloid fibrillogenesis, there are no reports of this type of amyloidosis in humans. We propose that this study reveals a new form of hereditary amyloidosis (AApoCII) that is derived from the Apo-CII protein and appears to manifest in the elderly and preferentially affect the kidneys.
Choroidal Metastases
Authors: Michele R. Piccone, Albert M. Maguire, Kevin C. Fox, Kym Gendron
Journal: Journal of Clinical Oncology (1999)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1999.17.10.3356 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10506638 Choroidal Metastases Michele R. PicconexMichele R. PicconeSearch for articles by this author , Albert M. MaguirexAlbert M. MaguireSearch for articles by this author , Kevin C. FoxxKevin C. FoxSearch for articles by this author , Kym GendronxKym GendronSearch for articles by this author Show More Scheie Eye Institute, Philadelphia, PA https://doi.org/10.1200/JCO.1999.17.10.3356 First Page Full Text PDF Figures and Tables © 1999 by American Society of Clinical Oncology
Psychotropic drug withdrawal and the dexamethasone suppression test
Authors: R P Kraus, M Hux, P Grof
Journal: American Journal of Psychiatry (1987)

In a prospective study of 25 patients from the time of hospitalization, seven had recently discontinued psychotropic agents (including antidepressants, neuroleptics, and benzodiazepines). All seven had positive dexamethasone suppression test results after 1 week of hospitalization. This phenomenon did not occur in any of the other subjects who had not discontinued such medications. Some of the subjects with postdexamethasone cortisol increases reported drug discontinuation in the drug histories they gave at admission, but in three, drug screening provided the only evidence of prior drug use. Medication withdrawal may be an underappreciated confounding variable in DST studies.
Two decades of involuntary hospitalization legislation
Authors: B Wanck
Journal: American Journal of Psychiatry (1984)

In 10 of the 13 cases the author examined, after passage of a state statute affecting involuntary admission to state psychiatric hospitals the percentage of involuntary admissions changed significantly in the direction intended by the legislature. The findings support the hypothesis that state laws significantly influence involuntary admission rates and, consequently, clinical practice. The findings also demonstrate that legislative intent in the late 1960s and early 1970s supported restriction of involuntary hospitalization and that a move toward liberalization of its use occurred in the late 1970s. The author recommends greater involvement by psychiatrists in the formulation of legislation that has an influence on their clinical work.
Childhood Obesity, Breastfeeding, Intestinal Microbiota, and Early Exposure to Antibiotics
Authors: Giulia Paolella, Pietro Vajro
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Prevalence and Gross Morphologic Features of Perianal Melanocytic Nevi
Authors: Ava Socik, Autumn Burnes, Arthur R. Rhodes
Journal: JAMA Dermatology (2016)

The presence of numerous melanocytic nevi is a significant melanoma risk factor, but there are scant data related to prevalence and morphologic features of melanocytic nevi in the perianal area. The prognosis of perianal melanoma is often dismal because of hidden location and diagnosis delay.To determine prevalence and morphologic features of perianal melanocytic nevi.This study was conducted for 11 months during 2013 and 2014 at an outpatient dermatology clinic in Chicago, Illinois, with a convenience sample of 236 adults (men and women of all races, ≥18 years) presenting to 1 dermatologist for melanoma and/or skin cancer screening or surveillance. The analysis was conducted during April through July 2015.Prevalence and morphologic features of perianal nevi according to race/ethnicity, sex, and age.Of 236 participating patients, 219 were non-Hispanic white; 4, Hispanic white; and 13, nonwhite. Patients included 138 men and 98 women, ages 23 to 84 years (median age, 55 years; mean [SD], 53 [15] years). Perianal nevi of any size, at least 2 mm in diameter, and at least 5 mm in diameter were evident in 48.9% (107 of 219), 39.7% (87 of 219), and 5.5% (12 of 219) of non-Hispanic whites, respectively; 50.0% (2 of 4), 0 (0 of 4), and 0 (0 of 4) of Hispanic whites, respectively; and 38.5% (5 of 13), 38.5% (5 of 13), and 0 (0 of 13) of nonwhites, respectively. In non-Hispanic whites, the presence of at least 1 perianal nevus was significantly associated with history of atypical nevus excision (odds ratio [OR], 2.9; 95% CI, 1.5-5.7); and extant findings of at least 1 atypical nevus (OR, 2.2; 95% CI, 1.3-3.9); atypical nevus pattern (≥20 nevi that were ≥2 mm in diameter), plus at least 5 nevi that were 5 mm or greater in diameter (OR, 1.8; 95% CI, 1.1-3.1); and at least 4 atypical nevi 5 mm or greater in diameter (OR, 1.9; 95% CI, 1.1-3.3).In this study, perianal melanocytic nevi were common and were associated with prominent and atypical nevi elsewhere. The perianal area is worthy of attention during melanoma screening and surveillance.
Measles genotypes D4 and G3 reintroduced by multiple foci after 15 years without measles virus circulation, Gipuzkoa, the Basque Country, Spain, March to June 2011
Authors: G Cilla, M Montes, J Artieda, L Piñeiro, L Arriola, E Pérez-Trallero
Journal: Eurosurveillance (2011)

During a three-month period in spring 2011, 23 cases of measles occurred in seven independent outbreaks in a region in Spain with around 700,000 inhabitants, where the disease had been eliminated since 1997. High vaccination coverage and rapid diagnosis allowed implementation of containment measures and this prevented spread of the disease. Except for the first outbreak which affected 10 cases, each of the other six outbreaks caused a maximum of three secondary cases.
The Stories
Authors: A Scheetz, M E Fry
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia
Authors: C M Banki, G Bissette, M Arato, L O'Connor, C B Nemeroff
Journal: American Journal of Psychiatry (1987)

To further investigate the hypothesis that hyperactivity of the hypothalamic-pituitary-adrenal axis in patients with depression may be mediated by hypersecretion of corticotropin-releasing factor (CRF), the authors measured CRF-like immunoreactivity in CSF samples from 138 neurological control, 54 depressed, and 27 nondepressed (23 schizophrenic and four manic) subjects. The CSF CRF concentration was markedly higher (almost twofold) in depressed patients than in control subjects and nondepressed psychiatric patients. The concentration of CSF CRF was slightly but significantly higher in schizophrenic patients than in control subjects. These findings provide further support for the hypothesis that CRF hypersecretion occurs in major depression.
Soundings: Man's best friend
Authors: Liam Farrell
Journal: BMJ (2005)

Dysorganophilia (Farrell's syndrome): excessive affection for an abnormal body part.

When I was a lad I had a papilloma on my left upper arm, and had no need of thumbsucking or a security blanket; I had Bob to twiddle, and we went everywhere together.

“Isn't he a gorgeous little thing?” girlfriends would say, admiring the elegant stalk, the smooth bulbous head, but as I grew older, more mature and sophisticated, and conscious of the importance of physical perfection, I became embarrassed by Bob. Even on nudist beaches, where I was unashamed to let everything else hang out, I would hide Bob with a bandage.

Eventually I decided Bob had to go.

Distinctly I remember it was in the dark of December, and the razor felt cold, ice against my skin. The vorpal blade went snicker-snack and a drop of blood welled up like a last tear—had I heard a sad little sigh? I left Bob dead and with his head I went galumphing back to the world of normal people.

But years later, I found I was not alone.

Joe refused to have Norm removed, as he had become rather inappropriately fond of his hydrocoele. As I had worn the T shirt, I could empathise; Norm was cheaper and less troublesome than a pet, didn't leave a mess, didn't need a licence, didn't need to be taken for walks.

Every so often, when Norm became so large that Joe required an extra seat on the bus he would let me drain off a few gallons, but it was a procedure that caused him considerable distress.

“Ah, look at the poor wee thing, don't be taking too much now,” he would say. “No more, no more, for God's sake hasn't he suffered enough?”

“There, there,” I would say, as counselling is so important; sometimes I think I care too much.

Joe would then stand shaking himself for a few moments, getting used to his altered centre of gravity. His mood would also be altered, but as the weeks passed and the implacable forces of physiology forced vibrant life-affirming fluids back into the temporarily flaccid Norm, Joe would regain his jaunty good humour.

“And Norm gives my girlfriends such a scare,” he said, grinning evilly.

“I don't know about your girlfriends,” I said, like the Iron Duke reviewing his troops before Waterloo, “but by God, he scares me.”
Influence of T-Helper Cell Specific Monoclonal Antibody on Progressive Growth of B-Cell Lymphomas in SJL/J Mice: Correlation of Acute Treatment Dosage with Tumor Dormancy or Complete Remission in Long-term Survivors
Authors: R M Alisauskas, C A Friedman, N M Ponzio
Journal: Cancer Communications (1990)

Transplantable follicular center cell lymphomas of SJL/J mice (SJL/FCC) are B-cell-derived tumors that stimulate host T-helper (TH) cells and grow progressively in the lymphoid tissues of immunocompetent, syngeneic recipients. The host TH cells that respond to the I-As determinants on SJL/FCC lymphoma cells produce a variety of lymphokines, some of which (e.g., IL-5) promote in vitro tumor growth. The results presented here demonstrate that removal of the cellular source of tumor growth-promoting lymphokines by treatment of lymphoma-injected mice with TH cell specific monoclonal antibodies (anti-L3T4a) inhibits progressive tumor growth and prolongs survival significantly. However, long-term survival is mediated by different mechanisms, depending on the dosage of L3T4a mAb used. Tumor cells are present, but dormant, in mice that receive low-dose (less than 200 micrograms/injection) treatment. In contrast, tumor cells are undetectable in mice that receive high dose (1200 micrograms/injection) treatment.
Effects of Podophyllin on Mouse Skin. I. Histologic Sequence after a Single Dose&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: L S KING
Journal: JNCI Journal of the National Cancer Institute (1948)

Effects of Podophyllin on Mouse Skin. I. Histologic Sequence after a Single Dose Get access Lester S. King, M. D. Lester S. King, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 5-6, April-June, Pages 215–225, https://doi.org/10.1093/jnci/8.5-6.215 Published: 01 April 1948 Article history Received: 26 March 1948 Published: 01 April 1948
Authors’ response: Is a reduced duration of post-discharge surgical site infection surveillance really in our best interests?
Authors: M B Koek, Collective on behalf of the authors of the original article
Journal: Eurosurveillance (2015)

Preview this article: Authors’ response: Is a reduced duration of post-discharge surgical site infection surveillance really in our best interests?, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/20/13/art21082-en-1.gif
State Expenditures for Tobacco-Control Programs and the Tobacco Settlement
Authors: Joseph W Thompson, I Dodd Wilson, Mike Huckabee
Journal: New England Journal of Medicine (2003)

Background-Despite controversy surrounding the use of funds arising from settlement agreements with the tobacco industry, little is known about the role of these funds in expenditures for state tobacco-control programs.Methods-We evaluated state expenditures for tobacco-control programs in fiscal year 2001 in the context of the amount of tobacco-settlement funds received and allocated to tobacco-control programs and in the context of other state-level economic and health data.Results-In 2001 the average state received $28.35 per capita from the tobacco settlement but allocated approximately 6 percent of these funds to tobacco-control programs.The average state dedicated $3.49 per capita (range, $0.10 to $15.47) to tobacco-control programs.The proportion of settlement funds allocated to tobacco-control programs varied from 0 to 100 percent and was strongly related to levels of tobacco-control funding (P<0.001).States with higher smoking rates tended to invest less per capita in tobacco-control programs (P=0.007), as did tobacco-producing states (the mean per capita expenditure was $1.20, as compared with $3.81 in non-tobaccoproducing states; P<0.008).In a multivariate analysis, the proportion of the settlement revenue allocated to tobacco-control programs was the primary determinant of the level of total funding; the state tobacco-related health burden was unrelated to program funding.Conclusions-State health needs appear to have little effect on the funding of state tobaccocontrol programs.Because only a very small proportion of the tobacco settlement is being used for tobacco-control programs, the settlement represents an unrealized opportunity to reduce morbidity and mortality from smoking.
CR-19PROSPECTIVE DYNAMIC EVALUATION OF HYPOTHALAMO-PITUITARY FUNCTION IN PAEDIATRIC CRANIOPHARYNGIOMA, BY HYPOTHALAMIC INJURY AND TREATMENT; A SINGLE CENTRE SERIES
Authors: Chiara Guzzetti, Laura Losa, Nicola Improda, Gloria Pang, Voraluck Phatarakijnirund, Hoong-Wei Gan, Richard Hayward, Kristian Aquilina, Ash Ederies, Helen A. Spoudeas
Journal: Neuro-Oncology (2016)
LMI-12CLINICAL PROFILE, MANAGEMENT AND OUTCOME OF PEDIATRIC BRAIN TUMOR IN A TERTIARY CARE ONCOLOGY CENTER IN NEPAL: REPORT FROM A DEVELOPING COUNTRY
Authors: Subhas Pandit, Surendra Gauchan, Anjani Jha
Journal: Neuro-Oncology (2016)

LMI-12. CLINICAL PROFILE, MANAGEMENT AND OUTCOME OF PEDIATRIC BRAIN TUMOR IN A TERTIARY CARE ONCOLOGY CENTER IN NEPAL: REPORT FROM A DEVELOPING COUNTRY Subhas Pandit, Surendra Gauchan, and Anjani Jha; BPKMCH, Narayani, Nepal OBJECTIVE: Multi disciplinary pediatric neuro-oncology is still in nascent stage in developing countries. This study was done to determine clinicopathological profile and treatment of pediatric brain tumor patients treated in a tertiary oncology center in Nepal. METHODS: A retrospective review of all cases treated in our unit from 2011-2014 was done. We report clinicalpathological status and treatment of patients treated in our center after conformal radiotherapy was initiated. RESULTS: Twenty-four patients were identified and treated at BPKMCH. Median age at diagnosis was 9 years (4-17years) and sex distribution was male 18(75%) and female 6(25%). Site was supratentorial in 8(33%) and infratentorial in 15(33%) patients. Medulloblastoma was most common tumor histology in 6(25%) patients followed by brainstem glioma in 5(21%),ependymoma in 4(16%), glioblastoma-2,craniopharyngioma-2 and others 5 .Two patients refused further treatment after diagnosis while 4 patients had incomplete treatment (no adjuvant treatment after surgery). All patients with medulloblastoma underwent surgery and cranio-spinal radiotherapy using CT scan based 3D conformal technique. Four of those patients received adjuvant chemotherapy. Brainstem glioma patients were treated with primary radiotherapy without surgery/biopsy. Other histology underwent surgery and post operative radiotherapy with 3D conformal radiotherapy technique. Ten patients are in follow up since 12.6 to 30.3 months. CONCLUSION: Providing multi disciplinary pediatric brain tumor service is a difficult task in resource-poor setting. High morbidity and incomplete treatment rate (25%) with our present treatment calls for improvement in management including better supportive care for better adherence to treatment. Neuro-Oncology 18:iii123–iii126, 2016. doi:10.1093/neuonc/now077.11 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Peroral endoscopic pyloromyotomy for delayed postoperative gastroparesis
Authors: Amol Bapaye, Nachiket Dubale, Rajendra Pujari, Amol Kulkarni, Rucha Jajoo Naval, Viral Vyas, Mahesh Mahadik
Journal: Endoscopy (2015)

Functional gastric outlet obstruction, or gastroparesis, occurs in 20 % to 30 % of patients following esophagogastric surgery and has significant morbidity [1]. Per-oral endoscopic pyloromyotomy (POEP) has been reported in pigs [2] and recently in humans for the treatment of diabetic gastroparesis [3] or postoperative gastroparesis [4] [5]. We report here two patients with delayed postoperative gastroparesis successfully treated by POEP.
Case 23-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Francis M. Ingersoll, Stanley J. Robboy
Journal: New England Journal of Medicine (1980)

Presentation of CaseA 34-year-old nulliparous woman was admitted to the hospital because of right-sided pelvic pain.Twelve years before admission the patient experienced right-sided pelvic pain during ovulation and menstruation; a physician palpated a right ovarian cyst. The pain worsened progressively; 11 years before entry a laparotomy revealed a ruptured right ovarian cyst, and a cystectomy and appendectomy were performed. Subsequently, she had bilateral pelvic pain that was exacerbated during ovulation and menses. Dyspareunia developed and persisted, and the patient observed a recurrent white or yellow vaginal discharge, with pruritus, which was ascribed to yeast infections. Ten years before . . .
Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
Authors: Sarah J. Mitchell, Julio Madrigal-Matute, Morten Scheibye-Knudsen, Evandro Fang, Miguel Aon, José A. González-Reyes, Sonia Cortassa, Susmita Kaushik, Marta Gonzalez-Freire, Bindi Patel, Devin Wahl, Ahmed Ali, Miguel Calvo-Rubio, María I. Burón, Vincent Guiterrez, Theresa M. Ward, Hector H. Palacios, Huan Cai, David W. Frederick, Christopher Hine, Filomena Broeskamp, Lukas Habering, John Dawson, T. Mark Beasley, Junxiang Wan, Yuji Ikeno, Gene Hubbard, Kevin G. Becker, Yongqing Zhang, Vilhelm A. Bohr, Dan L. Longo, Placido Navas, Luigi Ferrucci, David A. Sinclair, Pinchas Cohen, Josephine M. Egan, James R. Mitchell, Joseph A. Baur, David B. Allison, R. Michael Anson, José M. Villalba, Frank Madeo, Ana Maria Cuervo, Kevin J. Pearson, Donald K. Ingram, Michel Bernier, Rafael de Cabo
Journal: Cell Metabolism (2016)
MB-18DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION
Authors: Daisuke Kawauchi, Weijun Feng, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Lieberman, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanand Rajendran, Bola Hanna, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David Jones, Marcel Kool, Paul Northcott, Felipe Cortés-Ledesma, Stefan Pfister, Haikun Liu
Journal: Neuro-Oncology (2016)
LG-54GENOMIC PROFILES OF PEDIATRIC LOW GRADE GLIOMAS IN JAPAN: A NON-NGS APPROACH
Authors: Kai Yamasaki, Yoshiko Nakano, Shintaro Fukushima, Hirokazu Takami, Kaoru Tamura, Hiroko Fukushima, Yasuhiro Matsusaka, Keiko Okada, Hiroyuki Fujisaki, Motoo Nagane, Keisuke Ueki, Takeshi Inoue, Hiroaki Sakamoto, Junichi Hara, Koichi Ichimura
Journal: Neuro-Oncology (2016)