tbuckley/cabot-search huggingface dataset:
SAT0407 Baseline Characteristics in Psoriasis Patients with Polyarthritis or Oligoarthritis: Table 1
Authors: P. Helliwell, H. Jones, A. Szumski, L. Marshall
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Polyarthritis (PA) is defined by inflammation of ≥5 joints differentiating it from oligoarthritis (OA) which affects 2-4 joints. There are limited data on the demographic and disease characteristics of psoriasis patients with either OA or PA. <h3>Objectives</h3> Our analyses examined and characterized the baseline attributes of psoriasis subjects with PA and OA in the PREPARE trial. <h3>Methods</h3> PREPARE was a multicenter non-interventional study conducted to estimate PsA prevalence in patients with psoriasis. Diagnosis of PA and OA was based on clinical examination by rheumatologists. Demographic and disease characteristics were assessed among patients with PA or OA at baseline. <h3>Results</h3> A total of 406 subjects were included in these analyses; of these 222 (54.7%) had PsA following rheumatologist assessment (based on physical examination, medical history and laboratory analysis). At baseline, 253 patients had PA and 153 had OA. A significantly greater proportion of patients with PA (161/252; 63.9%) had PsA than those with OA (61/152; 40.1%) (P&lt;0.001). Among patients with PsA, CASPAR scores were significantly higher among the PA group than the OA group (P=0.0128); 54.6% of PA patients had a CASPAR score ≥4 compared with 41.0% of AO patients. Extent of skin disease was similar for PA vs OA patients (BSA: 9.9% vs 8.9%; NAPSI: 2.2 vs 2.0; PASI: 7.0 vs 6.7). Patients with PA had significantly higher DAS28 and HAD Anxiety and Depression Scores and a significantly lower EQ-5D score than those with OA (Table 1). Percent of activity impaired and work time missed was also significantly higher in the PA group than the OA group. <h3>Conclusions</h3> Psoriasis patients with OA and PA exhibit different phenotypes. Patients with PA had a significantly higher burden of disease and work impairment than those with OA as demonstrated by the baseline outcome data presented here. Similar levels of skin disease were observed for psoriasis patients with PA and OA. <h3>Acknowledgements</h3> The PREPARE study (ClinTrials.gov NCT01147874) was sponsored by Pfizer Inc. Medical writing support was provided by John Bilbruck of Engage Scientific and was funded by Pfizer Inc. <h3>Disclosure of Interest</h3> P. Helliwell Grant/research support: Pfizer, Abbie, Consultant for: Abbvie, Celgene, Pfizer, Novartis, Janssen, UCB, BMS, Eli-Lilly and Merck, H. Jones Employee of: Pfizer, A. Szumski Employee of: Pfizer, L. Marshall Employee of: Pfizer <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2110
192 RIFAXIMIN IMPROVES COGNITION AND ENDOTOXEMIA IN MINIMAL HEPATIC ENCEPHALOPATHY BY SHIFTING GUT MICROBIAL FUNCTIONALITY WITHOUT ALTERING THEIR ABUNDANCE
Authors: J.S. Bajaj, D. Heuman, A. Sanyal, P. Hylemon, R.K. Sterling, R.T. Stravitz, M. Fuchs, J.M. Ridlon, K. Daita, P. Monteith, M. White, N.A. Noble, A. Fisher, M. Sikaroodi, H. Rangwala, P.M. Gillevet
Journal: Journal of Hepatology (2013)
AB0576 The frequency of autoimmune thyroid disorders in patients with psoriatic arthritis and the effect of anti tnf-alpha treatment on autoimmune thyroid disease.
Authors: E. F. Tarhan, G. G. Oruk, U. Karaoǧullarından, G. Can
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Psoriatic Arthritis (PsA)is an inflammatory rheumatic disease accompanied by psoriasis. Coexistence of autoimmune thyroid disorders and rheumatic diseases such as Sjögren's syndrome, systemic lupus erythematosus and rheumatoid arthritis has been shown in many studies. <h3>Objectives</h3> In this study, the frequency of thyroid disorders in PsA patients and the effect of anti TNF-α treatment on autoimmune thyroid disease were investigated. <h3>Methods</h3> Thyroid stimulating hormone, triiodothyronine, thyroxine, antithyroglobulin(Tg) and anti-thyroid peroxidase (TPO) of 95 patients followed at the rheumatology outpatient clinic were retrospectively evaluated. Sixty-six patients with PsA (F/M: 43/23) whose data were complete, and 35 healthy controls (F/M: 25/10) were included in the study. Thyroid ultrasonography was applied to all cases by an endocrinology specialist. <h3>Results</h3> 38 of the PsA patients received disease modifying antirheumatic drugs (DMARDs) (Group 1; mean age: 43.94±9.81), and 28 anti TNF-α treatment (Group 2; mean age:42.25±11.48). Group 3 was comprised of healthy controls (mean age: 40.52±8.34). Significant differences were observed (p&lt;0.05) between the mean anti-TPO values (121.35±1.13; 38.25± 15.88) and anti-Tg values (68.48±8.35; 27.33±1.48) of groups 1 and 2 (p&lt;0.05). Similarly, significant differences were established (p&lt;0.05) between mean anti-TPO values (121.35±1.13; 51.94±33.55) and anti-Tg values (68.48±8.35; 37.62± 2.12) of groups 1 and 3 (p&lt;0.05). There were significant differences (p&lt;0.05) between the mean anti-TPO values (38.25±15.88; 51.94±33.55) and anti-Tg values (27.33±1.48; 37.62± 2.12) of groups 2 and 3 (p&lt;0.05). Thyroid nodules were observed in 20 patients in group 1, 5 patients in group 2 and 3 cases in group 3. Subclinical hypothyroidism in 1 patient, subclinical hyperthyroidism in 1 patient and clinical hypothyroidism in 1 patient were discovered in group 1. There was 1 patient with subclinical hypothyroidism and 1 with clinical hypothyroidism in group 2. In group 3, only 1 patient with subclinical hypothyroidism was identified. <h3>Conclusions</h3> As a result, autoimmune thyroid disorders were observed more frequently in patients with PsA than in the control group. The PsA patients who are receiving DMARDs appeared to have autoimmune thyroid disorders more frequently than those receiving anti TNF-α treatment. This condition may be resulting from TNF-α on the pathogenesis of thyroid disorders. Further studies are needed to clarify this effect. <h3>Disclosure of Interest</h3> None Declared
Persistent High Hopes Held for Colony Stimulating Factors
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Persistent High Hopes Held for Colony Stimulating Factors Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 24, December 1993, Pages 1982–1983, https://doi.org/10.1093/jnci/85.24.1982 Published: 01 December 1993
Truly Emerging — A New Disease Caused by a Novel Virus
Authors: Heinz Feldmann
Journal: New England Journal of Medicine (2011)

Contrary to predictions of the mid-20th century, infectious diseases are on the rise, threatening human and animal health on both local and global scales. Multiple factors are contributing to the emergence or reemergence of infectious diseases, including increasing human intrusion into the natural environment, with behavioral changes associated with expanding economic development.1 In addition to the global viral killers (e.g., human immunodeficiency virus and influenza virus), which are huge regional and global public health burdens, viral zoonoses in particular have become more prominent worldwide. A multidisciplinary approach to addressing zoonotic diseases is being promoted, and the “one world, one health” . . .
IMPACT OF THE AMERICAN HEART ASSOCIATION’S 2007 GUIDELINES ON THE PRACTICE OF DENTAL PROPHYLAXIS FOR THE PREVENTION OF INFECTIVE ENDOCARDITIS IN HIGH RISK PATIENTS: OLMSTED COUNTY, MINNESOTA
Authors: Daniel Christopher DeSimone, Abdelghani El Rafei, Douglass W. Challener, Alan B. Carr, James A. Kelly, Jennifer L. St. Sauver, Brian Lahr, James Steckelberg, Walter Wilson, Larry Baddour
Journal: Journal of the American College of Cardiology (2016)
Multimodality treatment of non small cells lung cancer (NSCLC) brain metastases: Long term outcome
Authors: A. Cassano, A. Pompucci, E. D’Argento, G. Schinzari, A. Di Chirico, P. De Bonis, M. Quirino, M. Basso, C. Anile, C. Barone
Journal: Journal of Clinical Oncology (2006)

17046 Background: Lung cancer is the most common cause of cancer deaths and has the highest incidence for brain metastases of all malignancies. The prognosis of these patients (pts) remain poor with a median survival of 4–5 months. Whole brain radiation therapy (WBRT) in inoperable brain metastases prolongs survival to 3–5 months. In pts with 1 or ≤ 3 brain metastases neurosurgical resection improves median survival to 3.5–8 months. The aim of this study was to evaluate the long-term outcome of patients with brain metastases from NSCLC treated with multimodal strategy, including systemic chemotherapy, neurosurgery and radiotherapy. Methods: From 1997 to 2005, 56 pts were considered. Inclusion criteria were: single or multiple NSCLC brain metastases suitable of surgery; Karnofsky performance status ≥ 70%; controlled extracranial disease with Cisplatin-based chemotherapy; life expectancy &gt; 4 months. Surgery was followed by 40 Gy WBRT. Statistical analysis was performed using the Kaplan-Meier method and Cox-regression analysis. Results: The median age was 58.4 years. The histological types were adenocarcinoma in 35 pts (62.5%), squamous cell carcinoma in 11 pts (19.7%) and large cell carcinoma in 10 pts (17.8%). The lesions were single in 39/56 pts (69.6%) and multiple in the other pts (30.4%). Radical surgery was performed in 37 pts (66%), while surgical citoreduction was possible in 19 pts (34%). The median follow-up period was 22.12 months (range 2–90 months). Overall survival (OS) of the whole group was 12.8 months; OS of pts radically resected was 16.5 months while OS of pts partially resected was 7.2 months. Based on Cox-regression analysis, age &lt; 65 years and radical resection were independent predictors of survival (respectively p = 0.004–95% CI 1.46–7.6 and p = 0.04–95% CI 1.03–4.97), while the number of lesions was not relevant in terms of OS. Conclusions: Analysis of long-term outcome seems to confirm that the combined treatment of NSCLC brain metastases is a primary therapeutic option. In our series of 56 patients, radical surgery, not the number of metastases, was related with prolonged survival. Further randomized studies comparing surgery+WBRT vs gamma-knife-radiosurgery could define the best therapeutic option in the different subsets of pts. No significant financial relationships to disclose.
Retrospective identification of human cases of West Nile virus infection in Austria (2009 to 2010) by serological differentiation from Usutu and other flavivirus infections
Authors: K Stiasny, S W Aberle, F X Heinz
Journal: Eurosurveillance (2013)

There is increasing evidence for the spread of West Nile virus (WNV) in southern, eastern and central Europe. In parallel, another flavivirus, the antigenically closely related Usutu virus, was introduced from Africa and first detected in Austria (2001), followed by Spain (2003), Hungary (2005), Italy (2006), Switzerland (2006) and Germany (2007). In Austria, human WNV infections have not previously been documented, although the virus was isolated from birds and detected in mosquitoes in 2008 and 2009. We therefore conducted a retrospective search for human cases of WNV infection using serum and cerebrospinal fluid samples collected from patients with central nervous system (CNS) disease in the summers of 2009, 2010 and 2011. Although all samples were negative for WNV by polymerase chain reaction, quantitative evaluation of standardised antibody assays with purified flavivirus antigens (including Usutu virus, which cross-reacts with WNV even in neutralisation assays) provided serological evidence for three autochthonous WNV infections in Austria: two in 2009 and one in 2010. Our data highlight the importance of raising awareness of WNV infections in Austria and neighbouring countries and suggest including testing for this infection in routine diagnostic practice of CNS diseases.
AB0470 Pauciimmune vasculitis and renal failure- 14 years experience in the “c.davila” nephrology teaching hospital- bucharest
Authors: O. Ailioaie, S. Stancu, A. Zugravu, G. Mircescu
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> ANCA vasculititides are autoimmune diseases that produce systemic and renal damage and have important consequences on patients` health. <h3>Objectives</h3> To investigate the epidemiology, clinical characteristics and response to therapy in renal pauciimmune vasculitis patients thet presented to “C. Davila” Nephrology Teaching Hospital in Bucharest. <h3>Methods</h3> Prospective study in patients admitted in our centre from December 1998 to December 2012. Patients were monitored using Birmingham Vasculitis Activity Score (BVAS) and Vascular Damage Index. Statistical analysis was performed using the programs EpiInfo and SPSS. <h3>Results</h3> 91 patients were investigated (59,3% female, 40,7% male), medium age 61,1+/-15,6 years. Time lag until diagnosis: 2 months (2-6). ANCA positivity: ANCA c(+): 20%, ANCA p (+): 47% and ANCA negative: 33%. At initial clinical presentation, renal involvement was present in 100% of patients, with a BVAS score of 18 (9-36), macroscopic hematuria: 40%, proteinuria: 1,46 +/- 1,6 g/g creatinine, medium serum creatinine 6 +/- 3,8 mg/dl. Patients presented systemic symptoms in 74,7% of cases, with a median BVAS score of 2,5+/-1,8. Pulmonary infiltrates were present in 44% of patients, and cutaneous manifestations in 12,2%. ANCA c positivity was more frequent in males (p=0,01) and in younger patients (p=0,01). ANCA c vasculitis had the most precocious start (p=0,05), most frequent pulmonary involvement (p=0,002) and had highest BVAS score (p=0,0017). Also ANCA c vasculitis patients presented with more severe disease, lowest hemoglobin (p=0,02), lowest albumin (p=0,01) and highest number of hematic casts (p=0,0001) and highest demand of dialysis, either temporary (p=0,03) or definitive (p=0,01). After induction therapy we obtained significant decrease of renal score (14,15 +/- 9,3), proteinuria (1,26+/- 0,28 g/g creatinin)and serum creatinine (3,2+/-2.2 mg/dl), that was maintained at 6 months post induction : renal score: 15,2+/- 10,7, proteinuria 1,2 +/-0,2 g/g creatinine and serum creatinine 2,7+/-1,9 mg/dl. Severe complications were sepsis followed by ESRD (19,8%) and death (6,6%). <h3>Conclusions</h3> Pauciimmune vasculitis is a severe condition, diagnosis may be delayed because of nonspecific signs and symptoms at onset. ANCA c positive patients have a more active glomerular disease, a better response to therapy but a higher risk of death, probably due to more frequent pulmonary damage. <h3>Disclosure of Interest</h3> None Declared
Abstract 3318: Phosphoproteomic profiling of glioblastoma stem cells to uncover mechanisms of radiation resistance
Authors: Emily Bassett, Kamalakannan Palanichamy, Arnab Chakravarti
Journal: Cancer Research (2015)

Abstract Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults. GBM tumors universally develop resistance to chemotherapy and radiation therapy; thus, there is an urgent need to develop novel treatment strategies. In this study, we identify signaling pathways altered specifically in radioresistant glioblastoma stem cells (GSCs) following radiation treatment, in order to identify mechanisms of radiation resistance. Protein phosphorylation is a highly regulated and dynamic post-translational modification that is the primary mechanism of signal transduction. We hypothesized that phosphoproteomic profiling of GSCs can be used to identify novel signaling pathways involved in GBM radioresistance. Phosphopeptides were isolated from three GSC lines and one differentiated GBM cell line before and after radiation treatment. Mass spectrometry-based global phosphoproteomic profiling was then utilized to quantify radiation-induced changes in protein phosphorylation. About 6,000 phosphopeptides mapping to about 2,300 phosphoproteins were quantified at two post-radiation timepoints (relative to untreated) across all four cell lines. Three biological replicates of each sample were analyzed by mass spectrometry to obtain statistical significance. Fold changes of phosphoproteins following radiation treatment were then mapped to canonical signaling pathways, and pathways altered specifically in radiation-resistant GSCs were identified. We conclude that different pathways are activated in GSCs compared to differentiated GBM cells following radiation treatment, and some of these pathways may mediate radioresistance. Future efforts will focus on validation of the mass spectrometry results in vivo, and cell-based assays to identify the role of specific phosphoproteins in radioresistance pathways. Results of this study will guide future efforts to develop radiosensitizing agents that, when used in combination with current treatments, may increase the survival of patients with this devastating disease. This study was supported by funds from The Ohio State University Comprehensive Cancer Center (to AC); NIH/NCI 1U10CA180850-01(to AC); NIH/NCI 1RC2CA148190 (to AC); NIH/NCI 2K12CA133250-06 (to AC); NIH/NCI/CTEP 1R01CA169368 (to AC); NIH/NCI 1R01CA11522358 (to AC), RTOG (to AC). Citation Format: Emily Bassett, Kamalakannan Palanichamy, Arnab Chakravarti. Phosphoproteomic profiling of glioblastoma stem cells to uncover mechanisms of radiation resistance. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3318. doi:10.1158/1538-7445.AM2015-3318
Recurrent rectosigmoid volvulus and fatal peritonitis after percutaneous endoscopic sigmoidostomy
Authors: J. Molina-Infante, M. Fernandez-Bermejo, J. Mateos-Rodriguez
Journal: Endoscopy (2012)

An 83-year-old woman with severe dilated cardiomyopathy and recurrent sigmoid volvulus ([Fig. 1]) who was resident in a nursing home refused to undergo surgery and instead decided to undergo formation of a percutaneous endoscopic colostomy. A colonoscopy was performed as far as the cecum after oral preparation, so that the left colon was detorsioned. At 22 cm from the anal verge, which was the first part of the sigmoid colon that could be transilluminated, a standard 22-Fr percutaneous endoscopic gastrostomy (PEG) tube (Compat Nuport, Novartis, Basel, Switzerland) was inserted transanally using the classical pull-through technique ([Fig. 2]). The patient recovered uneventfully and was discharged 3 days later. An initial follow-up visit did not reveal any complications ([Fig. 3]).
Human herpesvirus-6 as a possible cause of encephalitis and hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation
Authors: Y-J Kim, D-W Kim, D-G Lee, S-T Park, Y-H Park, C-K Min, S Lee, J-H Choi, J-W Lee, W-S Min, W-S Shin, C-C Kim
Journal: Leukemia (2002)
A Shift on “Pay for Delay” — Reopening Doors for Pharmaceutical Competition?
Authors: Erica J. Hemphill Kraus
Journal: New England Journal of Medicine (2012)

A July decision by the Court of Appeals for the Third Circuit broke with other recent decisions by presuming that pay-for-delay agreements — whereby brand-name drug companies pay generics manufacturers to delay marketing generic versions of drugs — are anticompetitive.
Pseudoaneurysm eroding into the duodenal bulb: an extremely rare case and treatment modality
Authors: Kristi Lopez, Dina Ahmad, Alisha Hinds, Hazem Hammad, Jonathan Godfrey, Michelle Matteson-Kome, Matthew Bechtold
Journal: Endoscopy (2014)

Pseudoaneurysm formation in the vessels near the pancreas is a rare complication in patients with chronic pancreatitis [1]. Treatment of bleeding pseudoaneurysms is difficult and rarely endoscopic. We present the case of a patient with chronic pancreatitis and a pseudoaneurysm eroding through the wall of the duodenal bulb, who underwent emergency endoscopic therapy for initial stabilization.
P-305 A Phase Ib Biomarker Trial of Naproxen in Patients at Risk for DNA Mismatch Repair Deficient Colorectal Cancer
Authors: E. Vilar, E. Stoffel, R. Lim, P. Lynch, Y.N. You, S. Lipkin, L. Vornik, J. Lee, M. Perloff, P. Brown
Journal: Annals of Oncology (2015)
State Bite Tobacco Use Among High School Students
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article State Bite Tobacco Use Among High School Students Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 16, 19 August 1992, Page 1232, https://doi.org/10.1093/jnci/84.16.1232 Published: 19 August 1992
Case 30-1994
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Ciaran P. Kelly, Fiona Graeme-Cook
Journal: New England Journal of Medicine (1994)

Presentation of CaseA 74-year-old woman was admitted to the hospital because of diarrhea with recurrent dehydration and severe weight loss.There was a history of an “irritable colon” for many years, manifested by intermittent diarrhea that usually lasted one or two days and resolved spontaneously. Evaluation elsewhere was reported to show lactose intolerance; a hiatus hernia with reflux esophagitis and peptic ulcer disease were shown on fiberoptic esophagogastroduodenoscopic examination seven months and four months before admission, with symptomatic improvement after the administration of omeprazole; an upper gastrointestinal series was said to reveal antral and pyloric scarring with gastric dilatation. . . .
Abortion issue goes to US courts
Authors: F. B Charatan
Journal: BMJ (1995)

The antiabortion groups and their lawyers have added a new weapon to their arsenal against physicians who perform abortions in the US: malpractice lawsuits. The nonprofit educational organization Life Dynamics generates material for personal injury lawyers and is participating in 80 cases. It has assembled 642 lawyers and 500 physicians in its abortion malpractice program. Life Dynamics calls for persons to support lawsuits to increase malpractice insurance rates of abortionists, thereby forcing them out of business. Its 2-day 1994 seminar in Texas addressed abortion injuries, an alleged link between abortion and breast cancer, and abortion as a likely source of post-traumatic stress disorder. A lawyer and general counsel of the Arizona Right-to-Life has filed two lawsuits against a Phoenix physician who performs abortion. The trial judge dismissed both cases and fined the lawyer for frivolous lawsuits. An appeal overturned the fines. The lawyer has three more lawsuits on the docket. The physician had complained to the Arizona Bar Association about the lawyer. Even though the physician's insurance company did not pay any claims, its underwriters deemed him an actuarial risk, thereby making him essentially uninsurable. Local medical associations have failed to take a position on the lawyer's legal misconduct because they do not want to alienate some members. The Planned Parenthood Federation of America agreed that the lawsuits brought against the Phoenix physician were fraudulent and that they do not aim to protect women but to revoke their right to choose.
CARDIOVASCULAR PROGNOSIS OF SEVERE RESISTANT HYPERTENSION AMONG UNCONTROLLED HYPERTENSIVES: A 4-YEAR PROSPECTIVE STUDY
Authors: Konstantinos P. Tsioufis, Alexandros Kasiakogias, Kyriakos Dimitriadis, Athanasios Kordalis, Dimitrios Aragiannis, Panagiotis Vasileiou, Costas Thomopoulos, Anastasios Milkas, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2016)
ANÁLISIS DE LA TASA DE RECUPERACIÓN DE PÓLIPOS DIMINUTOS. EXPERIENCIA EN UN CENTRO DE TERCER NIVEL
Authors: I Pérez, E Moreno, M Muñoz García-Borruel, L Guerrero, J Jurado García, B Agüera Arroyo, M Pleguezuelo Navarro, E Pérez, L Casais Juanena, A Hervás Molina, A Naranjo
Journal: Endoscopy (2014)

Introducción: La extirpación endoscópica de los adenomas colorrectales constituye una estrategia que reduce la mortalidad por cáncer colorrectal. La mayoría de estos pólipos son “diminutos” (1 – 5 mm). Aunque infrecuentemente degeneran, es importante su recuperación para análisis histopatológico. Es poco conocida su tasa real de recuperación en la práctica habitual.