tbuckley/cabot-search huggingface dataset:
Safety, feasibility and effectiveness of first in‐human administration of muscle‐derived stem/progenitor cells modified with connexin‐43 gene for treatment of advanced chronic heart failure
Authors: Adrian Gwizdala, Natalia Rozwadowska, Tomasz Jan Kolanowski, Agnieszka Malcher, Aleksandra Cieplucha, Bartlomiej Perek, Wojciech Seniuk, Ewa Straburzynska‐Migaj, Zofia Oko‐Sarnowska, Witold Cholewinski, Michal Michalak, Stefan Grajek, Maciej Kurpisz
Journal: European Journal of Heart Failure (2017)
Incidence of Spontaneous Closure of Outlet Ventricular Septal Defect.
Authors: Hideshi Tomita, Yoshio Arakaki, Toshikatsu Yagihara, Shigeyuki Echigo
Journal: Circulation (2001)

The present study examined the Doppler echocardiograms of 742 patients with an outlet ventricular septal defect (VSD) who were seen at the National Cardiovascular Center from 1987 to 1999. Of these, 450 patients were followed for longer than 1 year; 161 of these 450 were younger than 12 months when first examined. During follow-up, Doppler echocardiographic examination was repeated at least once a year. The medical charts of these patients were reviewed. Doppler echocardiographic findings were analysed in patients whose defect closed spontaneously:spontaneous closure at the age of 1-25 years was identified in 17 (3.8%) of 450 patients who were followed for longer than 1 year, and 7 (4.3%) of the 161 patients who were younger than 12 months at the first examination. All closed VSDs were originally smaller than 4 mm. Although 5 cases of 17 developed trivial deformity of the right coronary cusp, suggesting a prolapse, this did not progress. Of these 5, trivial aortic regurgitation (AR) was detected in one patient, while another patient in the group of 17 developed trivial AR without any deformity of the right coronary cusp. Aortic regurgitation was not progressive in either patient. An outlet VSD closes spontaneously in a small percentage of patients without developing progressive AR. (Jpn Circ J 2001; 65: 364 - 366)
In Vitro and In Vivo Anti-Myeloma Activity of PRLX, an Orally-Bioavailable Agent Against Cells with Constitutive Activation of Ras or Its Downstream Pathway.
Authors: Steffen Klippel, Jana Jakubikova, Lauren Jenkins, Joseph M. Negri, Yevgenia Tesmenitsky, Melissa Rooney, Jake Delmore, Douglas W. McMillin, R. Selliah, P. Robbins, Nicholas Mitsiades, Robert Schlossman, Sudhir Sahasrabudhe, Kenneth C. Anderson, Paul G. Richardson, Constantine S. Mitsiades
Journal: Blood (2007)
Prolonged Overall Survival with Pomalidomide and Dexamethasone in Myeloma Characterized with End Stage Disease.
Authors: Xavier Leleu, Murielle Roussel, Bertrand Arnulf, Philippe Moreau, Catherine Traulle, Mauricette Michalet, Claire Mathiot, Marie Odile Petillon, Gerald Marit, Margaret Macro, Brigitte Pegourie, Brigitte Kolb, Anne Marie Stoppa, Sabine Brechiniac, Laurent Garderet, Bruno Royer, Cyrille Hulin, Lotfi Benbouker, Olivier Decaux, Denis Caillot, Martine Escoffre-Barbe, Jean Paul Fermand, Herve AvetLoiseau, Michel Attal, Thierry Facon
Journal: Blood (2012)
Commentary: We’re under financial strain without prescriptions for gluten-free food
Authors: Gemma Gleed
Journal: BMJ (2017)

My daughter Piper became very ill at 18 months old: she was vomiting up to 20 times a day, had constant diarrhoea, and lost over a third of her body weight. I was so worried about her during the six months it took to get a diagnosis.

Once it became clear that it was not a stomach bug, the GP agreed to refer her to the gastroenterology team at the hospital, where blood tests indicated coeliac disease. Two weeks later biopsies showed that Piper definitely had coeliac disease.

Piper is now 10 and has eaten a gluten-free diet since the disease was diagnosed. Until August 2015 I could get some staple items …
Studies on the Intracellular Composition of Livers from Rats Fed Various Aminoazo Dyes
Authors: J. M. Price, E. C. Miller, J. A. Miller, G. M. Weber
Journal: Cancer Research (1950)

1.  The livers of rats fed either no azo dye or equimolar levels of 2′-, 3′-, or 2-methyl-4-dimethylaminoazobenzene, 3-methyl-4-monomethylaminoazobenzene, or 4′-fluoro-4-dimethylaminoazobenzene for 4 weeks were perfused, homogenized, and separated by differential centrifugation into nuclear, large granule, small granule, and supernatant fluid fractions. The original homogenate and the fractions were analyzed for protein, nucleic acids, riboflavin, and protein-bound aminoazo dye. The results obtained were compared with previous data on the livers of rats fed other aminoazo dyes and on the tumors induced by 4-dimethylaminoazobenzene.

2.  From these data it appears that the ingestion of 4-dimethylaminoazobenzene and its C-monomethyl derivatives caused increases in the amounts of protein and desoxypentosenucleic acid in the nuclear fraction; decreases in the amounts of protein, pentosenucleic acid, and riboflavin in the large granule fraction; and increases in the pentosenucleic acid content of the supernatant fluid fraction, which were roughly proportional to the carcinogenicities of the dyes fed. The weak carcinogen 3-methyl-4-monomethylaminoazobenzene was an exception in that it caused a significant reduction in the riboflavin content of the large granules. The changes caused by the strong carcinogen 3′-methyl-4-dimethylaminoazobenzene were not altered by raising the level of dietary casein from 12 to 24 per cent. 4′-Fluoro-4-dimethylaminoazobenzene did not fit into this series, since it failed to cause as great changes as would be expected from its high activity.

3.  2-Methyl-4-dimethylaminoazobenzene differed from the other dyes in that it caused an increase above normal in the number and total mass of the large granules; this fraction contained considerably more protein and riboflavin and less pentosenucleic acid than normal.

4.  Ingestion of any of these dyes gave rise to protein-bound aminoazo dye in each fraction of the liver cell; the highest concentration and greatest fraction of the total were always found in the supernatant fluid.

5.  Histological studies suggested that the alterations in the composition of the large granule fractions after ingestion of the dyes were due chiefly to changes in the numbers of large granules in the parenchymal liver cells, while proliferation of the bile duct-like cells may have been responsible for the alterations in the composition of the nuclear fraction. The increase in the amount of nuclear desoxypentosenucleic acid which occurred when highly carcinogenic dyes were fed was largely the result of an increase in the number of nuclei per unit weight of tissue.
Results of a Phase II Trial of Oral Bexarotene Combined with Interferon Alfa-2b for Patients with Cutaneous T-Cell Lymphoma (CTCL).
Authors: David J. Straus, Madeleine Duvic, Timothy Kuzel, Steven Horwitz, Marie-France Demierre, Patricia Myskowski, Kathleen Maignan, Steven Steckel
Journal: Blood (2004)
Safety and pharmacokinetics of single and multiple oral doses of MK-8742, an HCV NS5A inhibitor, in healthy subjects
Authors: Eric Mangin, Wendy W Yeh, Luzelena Caro, Concetta Lipardi, Anna Mitselos, Iain P Fraser, Patricia Jumes, Xiaobi Huang, Daniel Dreyer, Lucas Van Bortel, Joan R Butterton
Journal: Hepatology (2013)
Prognostic impact of postoperative morbidity after esophagectomy for esophageal cancer: Supplementary exploratory analysis of JCOG9907.
Authors: Hiroya Takeuchi, Junki Mizusawa, Ken Kato, Kozo Kataoka, Hiroyasu Igaki, Tetsuya Abe, Hisayuki Matsushita, Kazuhiko Hayashi, Satoru Nakagawa, Takaki Yoshikawa, Isao Nozaki, Takeshi Iwaya, Shinichi Kosugi, Motohiro Hirao, Harushi Udagawa, Soji Ozawa, Yasuhiro Tsubosa, Kenichi Nakamura, Nobutoshi Ando, Yuko Kitagawa
Journal: Journal of Clinical Oncology (2015)

155 Background: Although the impact of postoperative complications, especially infectious complications (IC), on long-term survival after transthoracic esophagectomy remains controversial to date, we hypothesized that postoperative IC may affect tumor recurrence and survival of the patients (pts) undergoing transthoracic esophagectomy. Methods: The data from JCOG9907 (Ando N; Ann Surg Oncol 2012) was used to estimate the influence of IC on the outcome of current standard preoperative chemotherapy followed by surgery for clinical stage II/III squamous cell carcinoma of the thoracic esophagus. IC were classified into three: pneumonia, anastomotic leakage, and the others. OS and PFS were estimated by landmark method at 6 months from randomization. Univariate and multivariate analyses using Cox proportional hazard model were performed to assess the impact of postoperative complications on the survival after right-transthoracic esophagectomy with extended lymphadenectomy. Results: Among the 152 analyzed pts, the incidence of overall IC was 36%, among which pneumonia and anastomotic leakage were observed both in 14%. OS of pts with any IC (n=54) was shorter than that of pts without IC (HR 1.66, 95%CI [1.02-2.71]) and PFS also tended to be shorter in pts with any IC (HR 1.44, [0.92-2.23]). OS of pts with pneumonia (n=22) was shorter than that of pts without pneumonia (HR 1.82, [1.01-3.29]), and PFS also tended to be shorter in pts with pneumonia (HR 1.50, [0.85-2.62]). OS of pts with anastomotic leakage (n=21) were nearly identical to that for pts without leakage (HR 1.06, [0.52-2.13]) and PFS was slightly shorter in pts with leakage (HR 1.28, [0.71-2.32]). Multivariate analysis revealed that pneumonia tended to compromise OS and PFS (HR 1.66, [0.87-3.17] and HR 1.37, [0.75-2.51]). Conclusions: This study reveals that postoperative morbidity, especially pneumonia may deteriorate the survival of pts undergoing esophagectomy after preoperative chemotherapy. Achieving esophagectomy without postoperative complications might prolong OS and PFS. Clinical trial information: NCT00190554.
Cardiovascular risk of patients with gout seen at rheumatology clinics following a structured assessment
Authors: Mariano Andrés, José Antonio Bernal, Francisca Sivera, Neus Quilis, Loreto Carmona, Paloma Vela, Eliseo Pascual
Journal: Annals of the Rheumatic Diseases (2017)

<h3>Objectives</h3> Gout-associated cardiovascular (CV) risk relates to comorbidities and crystal-led inflammation. The aim was to estimate the CV risk by prediction tools in new patients with gout and to assess whether ultrasonographic carotid changes are present in patients without high CV risk. <h3>Methods</h3> Cross-sectional study. Consecutive new patients with crystal-proven gout underwent a structured CV consultation, including CV events, risk factors and two risk prediction tools—the Systematic COronary Evaluation (SCORE) and the Framingham Heart Study (FHS). CV risk was stratified according to current European guidelines. Carotid ultrasound (cUS) was performed in patients with less than very high CV risk. The presence of carotid plaques was studied depending on the SCORE and FHS by the area under the curve (AUC) of receiver operating curves. <h3>Results</h3> 237 new patients with gout were recruited. CV stratification by scores showed a predominance of very high (95 patients, 40.1%) and moderate (72 patients, 30.5%) risk levels. cUS was performed in 142 patients, finding atheroma plaques in 66 (46.5%, 95% CI 37.8 to 54.2). Following cUS findings, patients classified as very high risk increased from 40.1% up to 67.9% (161/237 patients). SCORE and FHS predicted moderately (AUC 0.711 and 0.683, respectively) the presence of atheroma plaques at cUS. <h3>Conclusions</h3> The majority of patients presenting with gout may be at very high CV risk, indicating the need for initiating optimal prevention strategies at this stage. Risk prediction tools appear to underestimate the presence of carotid plaque in patients with gout.
Incorporation of Thalidomide into Up-Front Double Autologous Stem-Cell Transplantation (ASCT) for Multiple Myeloma Improves the Outcome in Comparison with Double ASCT without Thalidomide. Analysis of Baseline Factors Predicitve of Outcome.
Authors: Elena Zamagni, Nicoletta Testoni, Carolina Terragna, Paola Tacchetti, Chiara Nicci, Matteo Renzulli, Patrizia Tosi, Mauro Fiacchini, Francesca Patriarca, Francesco Di Raimondo, Giulia Perrone, Lucio Catalano, Francesco Casulli, Michela Ceccolini, Silvestro Volpe, Luciano Masini, Antonio Ledda, Annamaria Brioli, Sadia Falcioni, Alessandro Gozzetti, Catello Califano, Mariacaterina Pallotti, Claudia Cellini, Affra Carubelli, Piero Maria Stefani, Lucia Pantani, Michele Baccarani, Michele Cavo
Journal: Blood (2007)
Elevated Levels of Cell-Derived Microparticles with Procoagulant Activity in Cocaine Abusers: Association with Increased Thrombin Generation and a Prothrombotic State.
Authors: Jaime Pereira, Gino Alfaro, Teresa Massardo, Julio Pallavicini, Claudia Sáez, Manuela Goycoolea, Olga Panes, Diego Mezzano
Journal: Blood (2005)
Encouraging Results of Reduced Intensity Conditioning (RIC) Umbilical Cord Blood (UCB) Transplantation for the Treatment of Advanced Lymphoid Malignancies.
Authors: Claudio G. Brunstein, Susana Cantero, Qing Cao, Navneet Majhail, Brian McClune, Linda J. Burns, Marcie Tomblyn, Jeffrey S. Miller, Bruce R. Blazar, Philip B. McGlave, Daniel J. Weisdorf, John E. Wagner
Journal: Blood (2007)
Addition of Clofarabine to TLI/ATG Conditioning: Impact on Immune Reconstitution and Clinical Outcomes,
Authors: Brett Glotzbecker, Heidi Mills, Jacalyn Rosenblatt, Robin Joyce, James Levine, Dimitrios Tzachanis, Maryann Stevenson, Eyal C. Attar, Karen K. Ballen, Yi-Bin A. Chen, Vassiliki A Boussiotis, Jeffrey Zwicker, Katarina Luptakova, Jon E. Arnason, Jessica Bonhoff, Carol Delaney, Katharine Conway, Nancy Giallombardo, Jamie Mortellite, Jason Glass, Donna Fitzgerald, Stefanie O'Brien, Caitlin McMahon, Baldev Vasir, Dina Stroopinsky, Thomas R. Spitzer, David Avigan
Journal: Blood (2011)
Efficacy of the Novel Non-Quinone Based HSP-90 Inhibitor PU-H71 in JAK2V617F and MPLW515L-Induced Murine Models of Myeloproliferative Neoplasms.
Authors: Priya Koppikar, Sachie Marubayashi, Tony Taldone, Omar Abdel-Wahab, Nathan West, Alexander Gozman, James Ahn, Anna Rodina, Neha Bhagwat, Cyrus V. Hedvat, James E. Bradner, Gabriela Chiosis, Ross L. Levine
Journal: Blood (2009)
Stromal Cells Expressing Hedgehog-Interacting Protein Are One of the Main Regulators of the Hedgehog Signaling System in Myeloid Neoplasms
Authors: Masayoshi Kobune, Hiroto Horiguchi, Shohei Kikuchi, Satoshi Iyama, Kohichi Takada, Kazuyuki Murase, Kaoru Ono, Yusuke Kamihara, Yutaka Kawano, Tsuyoshi Hayashi, Tsutomu Sato, Koji Miyanishi, Yasushi Sato, Rishu Takimoto, Junji Kato
Journal: Blood (2012)
Factors Affecting Outcome of Related Allogeneic Hematopoietic Cell Transplantation in Patients with Fanconi Anemia.
Authors: Mouhab F Ayas, Khawar Siddiqui, Amal Al-Seraihy, Hassan El-Solh, Ali Al-Ahmari, Abdulrahman Al-Musa, Ashraf Khairi, Samer Markiz, Hasan Shahin, Viqaruddin Mohammed, Abdullah Al-Jefri
Journal: Blood (2012)
The ethnic profile of patients with birthmarks reveals interaction of germline and postzygotic genetics
Authors: S. Polubothu, V.A. Kinsler
Journal: British Journal of Dermatology (2017)

GNA11 and GNAQ are highly homologous genes encoding different Gα subunits of heterotrimeric G-proteins. We recently described post-zygotic activating mutations in GNA11 or GNAQ as causes of Phakomatosis Pigmentovascularis (PPV), and GNAQ mosaicism as a cause of Extensive Dermal Melanocytosis (EDM)1. GNAQ mosaicism has previously been found to cause Sturge-Weber syndrome (SWS) and isolated non-syndromic port-wine stain type capillary malformations 2.

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The risk of fracture among patients with psoriatic arthritis and psoriasis: a population-based study
Authors: Alexis Ogdie, Lauren Harter, Daniel Shin, Joshua Baker, Junko Takeshita, Hyon K Choi, Thorvardur Jon Love, Joel M Gelfand
Journal: Annals of the Rheumatic Diseases (2017)

Objective To determine the risk of fracture and osteoporosis among patients with psoriatic arthritis (PsA) and psoriasis, compared with the general population and patients with rheumatoid arthritis (RA). Methods A population-based cohort study was performed in The Health Improvement Network in the UK using data from 1994 to 2014. Patients aged 18–89 years with PsA or psoriasis and up to five unexposed controls matched by practice and start date within that practice were included. Patients with RA and matched controls were included for comparison. Severe psoriasis was defined by a code for psoriasis and either phototherapy or a systemic medication for psoriasis. Incidence and adjusted HRs (aHR) for fracture (all, hip, vertebral) were calculated. Results Patients with PsA (n=9788), psoriasis (n=158 323) and controls (n=821 834) were identified. Patients with PsA had an elevated risk of all fracture aHR 1.26 (1.06 to 1.27). Patients with mild psoriasis had elevated risk of all fractures, vertebral and hip fracture: aHR 1.07 (1.05 to 1.10), 1.17 (1.03 to 1.33) and 1.13 (1.04 to 1.22). Patients with severe psoriasis had significantly elevated risk of all fracture and vertebral fracture: aHR 1.26 (1.15 to 1.39) and 2.23 (1.54 to 3.22). Conclusions PsA and psoriasis are associated with an elevated risk for fracture.
Distress and breast cancer anxiety (BCA) among BRCA mutation carriers participating in MRI-based screening
Authors: K. Hill, E. Warner, M. Esplen, R. Bigenwald
Journal: Journal of Clinical Oncology (2006)

20001 Background: MRI has consistently been shown to be a more sensitive screening tool than mammography (M) but its lower specificity could have negative psychological effects. In a pilot study (SABCS 2004) no adverse psychological effects of MRI screening were found. A larger study was then done to look particularly at the impact of imaging recalls and biopsies. Methods: BRCA mutation carriers having breast screening with annual M, MRI, and ultrasound (US) + 6monthly clinical breast examination (CBE) were asked to complete questionnaires: 1 - 2 wks pre, 4 - 6 weeks after, and 6 months after their imaging. Questionnaires included the hospital anxiety and depression scale (HADS), a modified Kash breast cancer anxiety scale (BCAS), the monitor/blunter scale, a rating of overall health on a linear analog scale, a 4 category rating of anxiety related to each screening modality, and a description of any recent life altering events. Results: 54 women (29 BRCA1, 25 BRCA2) completed at least 2 questionnaires (median 3, range 2–5). Mean age was 44 (range 28–64). 26% were surveyed during their 1st round of screening. There was a very strong correlation between the BCAS and HADS anxiety with 19 (35%) having baseline BCA of whom 15 (79%) were monitors compared to 60% monitors among the patients without BCA. At baseline 41 (76%) indicated moderate/high MRI related anxiety compared to 61%, 46%, and 43% for M, U/S and CBE. Of the 16 patients (30%) who had recalls ± biopsy (n = 5) while on this study, 10 (63%) had elevated BCA and 3(19%) increased depression at baseline. In all but 2 women whose anxiety increased due to life events, no scores changed significantly after recall or biopsy. Only 1 cancer was diagnosed during the study period. In the other 38 women scores changed significantly only as a result of life events. Conclusions: Despite a high false positive rate, MRI-based screening had no detectable adverse psychological effects on BRCA mutation carriers in this study. No significant financial relationships to disclose.
Screening Tool for Bleeding Disorders in Women with Menorrhagia: Evaluation in a Prospective US Multi-Site Cohort.
Authors: Claire S. Philipp, Ambarina Faiz, Vanessa Byams, Connie H. Miller, John A. Heit, Peter A. Kouides, Roshni Kulkarni, Andrea Lukes, Sidney F. Stein
Journal: Blood (2008)
Anti-Tumor Activity of Single-Agent CCI-779 for Relapsed Mantle Cell Lymphoma: A Phase II Trial in the North Central Cancer Treatment Group.
Authors: Thomas Witzig, Susan Geyer, Irene Ghobrial, David Inwards, Rafael Fonseca, Scott Kaufmann, Paul Kurtin, Joseph Colgan, William Morice, Steven Alberts, Muhammed Salim, Kendrith Rowland, Shaker Dakhil, Roscoe Morton, Philip Stella
Journal: Blood (2004)
Constitutive TGF-β1 Deficiency Induces a Defect in Hematopoietic Stem/Progenitor Cell Compartment in Fetus and Neonate.
Authors: Claude Capron, Catherine Lacout, Yann Lecluse, Valérie Jalbert, Elisabeth Cramer Bordé, Anne Galy, Sabine Charrier, William Vainchenker
Journal: Blood (2008)
Fertility in Female Patients After Allogeneic Stem Cell Transplantation Following Reduced-Intensity Conditioning (RIC allo-SCT)
Authors: Emmanuelle Assouline, Roberto Crocchiolo, Thomas Prebet, Sabine Furst, Jean El-Cheikh, Broussais Florence, Diane Coso, Aude Charbonnier, Christian Chabannon, Norbert Vey, Gamerre Marc, Didier Blaise, Blandine Courbiere
Journal: Blood (2011)
Association Between Elevated Hemolysis at Diagnosis and Early Mortality and Risk of Thrombosis In Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients with Cytopenia
Authors: Jin Seok Kim, Jong Wook Lee, Sung-Soo Yoon, Je-Hwan Lee, Deog-Yeon Jo, Jun-Ho Jang, Yeo-Kyung Kim, Jooseop Chung, Sang Kyun Sohn
Journal: Blood (2010)
Radioimmunotherapy (RIT) of Refractory or Relapsed Hodgkin’s Lymphoma (HL) with 90Yttrium-Labelled Antiferritin Antibody.
Authors: Didier Decaudin, Rafaël Lévy, François Lokiec, Olivier Madar, Rémi Brossel, Franck Morschhauser, Valentine Songeur, Malika Djeridane, Jean Kadouche, Alain Pecking
Journal: Blood (2007)
Autocrine and Paracrine Regulatory Mechanisms of Growth Arrest-Specific Gene 6 Contribute to Disease Progression of Multiple Myeloma
Authors: Miki Furukawa, Hiroshi Ohkawara, Kazuhiko Ikeda, Emi Ito, Jun-ichi Imai, Yuka Yanagisawa, Reiko Honma, Shinya Watanabe, Satoshi Waguri, Kazuei Ogawa, Yasuchika Takeishi
Journal: Blood (2015)