tbuckley/cabot-search huggingface dataset:
INFLUENCE OF GLYCEMIC CONTROL ON CLOPIDOGREL RESPONSE IN PATIENTS WITH STABLE CORONARY ARTERY DISEASE: A SUB-ANALYSIS FROM A RANDOMIZED, DOUBLE-BLIND STUDY
Authors: Remo Holanda de Mendonca Furtado, Carlos Barbosa, Celia Strunz, Andre Franci, Fernando Menezes, Flavia Arantes, Elbio D Amico, Tania Rubia Flores Rocha, Paulo Genestreti, Jose Nicolau
Journal: Journal of the American College of Cardiology (2015)
Colorectal Carcinoma With Bone Metastases Detected by 18F-Choline PET/CT
Authors: Giorgio Treglia, Luca Ceriani, Jessica Barizzi, Gaetano Paone, Luca Giovanella
Journal: Clinical Nuclear Medicine (2014)

We report a case of metastatic colorectal carcinoma detected by F-choline PET/CT. A 72-year-old man with history of prostate cancer (previously treated with prostatectomy) underwent F-choline PET/CT for restaging. PET/CT revealed a focal area of increased F-choline uptake corresponding to a rectal nodule. Furthermore, 2 areas of increased radiopharmaceutical uptake were evident in the right clavicle and in the body of the 10th dorsal vertebra, corresponding to the osteolytic lesions. Based on these PET/CT findings, the patient underwent biopsy of the rectal nodule and left clavicular lesion. Histologic examination demonstrated the presence of a colorectal carcinoma metastatic to the bone.
What Has Kept the Antibiotic Miracle Alive?
Authors: Thomas F. O'Brien
Journal: New England Journal of Medicine (2011)

Being a germ isn't easy. Bacteria need tightly scripted genomes orchestrating precise functions to compete in a crowded microbial world. A lone strain may infect a sterile site in a bigger organism and escape competition, but it may then attract a lethal host response and antibiotic therapy.The strain of Enterococcus faecalis described by Arias et al. in this issue of the Journal 1 escaped the competing bacteria of its usual bowel habitat by infecting a patient's hemodialysis catheter site. It alone kept growing from catheter tips and blood cultures despite catheter removals and reinsertions.2 Susceptibility tests showed that the initial . . .
Chronic Lymphocytic Thyroiditis, Thyrotoxicosis, and Low Radioactive Iodine Uptake
Authors: Franklin B. Gluck, Martin L. Nusynowitz, Stephen Plymate
Journal: New England Journal of Medicine (1975)

To characterize four patients with thyrotoxicosis and a low radioactive iodine uptake, thyroid biopsies were performed, and iodine metabolism was studied. Histologic examination showed the presence of chronic lymphocytic thyroiditis, with no features of Graves's disease, in all. Detailed studies in one patient revealed insufficient metabolism of iodine to account for the clinical and chemical features of thyrotoxicosis, which implies that release of stored hormone by the inflammatory process causes the thyrotoxic state. The thyrotoxicosis in this entity subsides spontaneously. Thus, this form of thyrotoxicosis differs from the usual form found in Graves's disease in that histologie features of Graves's disease are absent, the radioactive iodine uptake is low, and specific antithyroid therapy is contraindicated. The observations further demonstrate that the radioactive iodine uptake remains a valuable tool in the diagnosis of thyrotoxicosis and the differentiation of its various forms.
Production of Impending Hepatic Coma by Chlorothiazide and Its Prevention by Antibiotics
Authors: Joseph E. Mackie, James M. Stormont, Robert M. Hollister, Charles S. Davidson
Journal: New England Journal of Medicine (1958)

DEVELOPMENT of impending hepatic coma, characterized by confusion, drowsiness and flapping tremor, has been described previously in patients with cirrhosis given nitrogenous substances by mouth — ammonium cation-exchange resins, ammonium salts, urea, methionine and increments in dietary protein.1 2 3 It has also been reported in patients given a carbonic anhydrase inhibitor, acetazolamide.4 We wish to report the production of impending hepatic coma in alcoholic patients with cirrhosis and ascites given chlorothiazide,∥ a nonmercurial diuretic agent. Its prevention by concurrent oral administration of broad-spectrum, nonabsorbable antibiotics was also observed.Materials and MethodsFive patients (4 males and 1 female) with alcoholic cirrhosis . . .
PTU-055 The association of co-existent non-ischaemic cardiac disease with morbidity and mortality following liver transplantation
Authors: H Steed, J A Leithead, K Kandiah, B K Gunson, J W Ferguson
Journal: Gut (2012)

<h3>Introduction</h3> The risk stratification of potential liver transplant candidates with co-existent non-ischaemic cardiac disease (CD) is particularly challenging given the masking effect of the haemodynamic dysfunction of advanced portal hypertension. Whether such patients have altered outcomes following liver transplantation remains unknown. Our aim was, therefore, to examine the effects of mild and moderate non-ischaemic CD on post liver transplant morbidity and mortality. <h3>Methods</h3> Single-centre study of patients undergoing first liver transplantation for chronic liver disease. To determine the effects of mild CD, the routine assessment trans-thoracic echocardiography reports of 246 patients transplanted 01/2007–03/2010 were reviewed. To determine the effects of moderate CD, patients transplanted from 1994-present were highlighted from a prospectively collected database. <h3>Results</h3> Mild CD 11.4%, 11.4%, 2.8%, and 0.8% of the 246 patients undergoing routine assessment echocardiography had left atrial dilatation, or mild mitral regurgitation, aortic regurgitation or aortic stenosis, respectively. After adjusting for confounding variables there was no association between left atrial dilatation (p=0.738) or mild mitral regurgitation (p=0.234) and a cardiac event post transplant. Similarly, there was no association between left atrial dilatation (p=0.146) or mild mitral regurgitation (p=0.157) and post transplant survival. Moderate CD Ten patients were transplanted with moderate CD: aortic valve replacement (4), moderate valvular dysfunction (2), HOCM (2), moderate left ventricular failure (1), mitral valvuloplasty (1). Two of these patients underwent simultaneous valve replacement surgery. Of these two patients, one had a peri-operative cardiac event and both were alive at 1-year. For the remaining eight patients who did not undergo intervention the cumulative incidence of a cardiac event by 1-year after transplantation was 68.7%, and the estimated 1-year survival was 46.7%. All three patients with a pre-existing aortic valve replacement that was not re-done had a cardiac complication: one patient developed bacterial endocarditis and awaits further valve replacement surgery, two died of cardiac failure at 90- and 200-days post transplant. <h3>Conclusion</h3> Chronic liver disease patients with co-existent moderate CD who receive a favourable cardiac risk assessment have greater than expected morbidity and mortality following liver transplantation. Our findings suggest that the severity of non-ischaemic CD is underestimated in this setting. <h3>Competing interests</h3> None declared.
Sestamibi Retention in Reactive Lymph Node Hyperplasia
Authors: W D Leslie, K T Riese, C Mohamed
Journal: Clinical Nuclear Medicine (2000)

A 52-year-old woman had mild hypercalcemia (maximum serum calcium level, 2.8 mmol/l; normal range, 2.1 to 2.6 mmol/l) with a mildly elevated serum parathyroid hormone level (73 ng/l; normal range, 12 to 72 ng/l). Parathyroid imaging performed to localize a presumed adenoma showed definite localization to the right side. At surgery, several large lymph nodes were found below the right lobe of the thyroid along the tracheoesophageal groove, and pathologic evaluation of one excised node indicated reactive lymph node hyperplasia. Subsequently, all four parathyroid glands were studied and found to be normal. On follow-up, the patient became normocalcemic. The results of repeated scanning performed 2 months after operation were normal. Although false-positive lymph node uptake has previously been described with subtraction techniques, this is the first time that reactive lymph nodes have been reported to show sestamibi retention with the double-phase technique.
SP0162 ACPA Fine Specificities: What do They Really Mean?
Authors: D. Van Der Woude
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Anti-Citrullinated Protein Antibodies (ACPA) come in many different flavors. Besides the CCP2-antigen commonly used in diagnostic tests, they can also recognize various other antigens, which determine the so-called antibody fine specificity. Numerous studies have investigated these ACPA fine specificities, but what has this taught us so far? How do ACPA fine specificities contribute to our understanding of RA, and are they of any use to our patients? This presentation will discuss not only the role of ACPA fine specificities in the pathophysiology of rheumatoid arthritis (RA), but also whether they can be used for diagnostic or prognostic ends. Regarding pathophysiology, the study of ACPA fine specificities has contributed to our understanding of the temporal development of the ACPA response. They have also provided new insights concerning the well-known association between RA and certain HLA alleles. Their role in diagnosis and prognosis of RA appears to be limited at the present time, but this lecture will also provide a glimpse of the future of ACPA fine specificity research and the promises ahead. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6296
Abstract 5413: Is a non-conjugated triple-helix forming oligonucleotide targeting the genomic HPRT locus capable of sequence specific mutagenesis
Authors: Reshat Reshat, Catherine Priestley, Mick Fellows, Mike O'Donovan, Nigel J. Gooderham
Journal: Cancer Research (2011)

Abstract Oligonucleotide strands have been shown to be capable of binding to duplex DNA in a sequence specific manner to form a triple-helix or triplex structure. Such phenomenons have been shown to induce mutation, as demonstrated using plasmid-based reporter constructs (Wang et al 1996, Science, 271, p802). These studies have engendered concern from the European Medicines Agency (EMEA) in regard to biotechnology derived pharmaceuticals such that antisense oligonucleotides may also form triplex structures in a sequence specific manner at genomic DNA with potentially mutagenic effects. In this study, we have examined the mutagenic potential of a non-conjugated triplex forming oligonucleotide (TFO27) targeting the genomic hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus. The mutagenicity of TFO27 was assessed using the human lymphoblastoid TK6 cell line through 6-thioguanine resistance (6TGr). Electrophoretic mobility shift assays were used to demonstrate triplex formation by TFO27 at the target motif at sub-nanomolar concentrations. As expected, a control oligonucleotide, SCR27, failed to form a triplex at the target motif. Subsequently, a range of transfection facilitators were evaluated for optimal delivery of a fluorescently labelled oligonucleotide probe. In preliminary experiments treating 3×106 cells, TFO27 appeared to produce a dose dependent increase in 6TGr mutants. Furthermore, TFO27 failed to induce mutation at the non-targeted thymidine kinase (TK) locus suggesting locus specificity for its mode of action. Moreover, SCR27 failed to induce mutation at both loci. However, TFO27 failed to induce mutation at the HPRT locus in experiments treating 10×106 cells. Increasing the oligonucleotide concentration had no effect on the number of 6TGr recovered. These contradictory findings are difficult to explain, but emphasise the importance of using appropriate target cell numbers in mutation assays. Overall, our data would suggest that triplex formation could occur in cells but chromatin structure, intranuclear pH, ion concentrations and nucleases are all potential barriers that probably influence the dynamics of triplex formation and stability. In view of these factors, we suggest that studies of the mutagenic potential of triplex formation are better performed at genomic loci rather than extra-chromosomal test systems. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5413. doi:10.1158/1538-7445.AM2011-5413
Splenic artery pseudoaneurysm treated with thrombin injection guided by endoscopic ultrasound
Authors: D. Chaves, F. Costa, S. Matuguma, M. Lera dos Santos, E. de Moura, F. Maluf Filho, P. Sakai
Journal: Endoscopy (2012)

Thrombin was first described as an aneurysmal occlusion agent in 1986. Since that time its therapeutic potential has been increasingly recognized. Percutaneous injection of thrombin has been reported as effective in the management of femoral pseudoaneurysms [1] [2]. We present a case of pancreatic pseudoaneurysm of the splenic artery, which was successfully treated using a new approach that consisted of thrombin injection under endoscopic ultrasound (EUS) guidance.
P256 THE EFFECT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-DELTA AGONIST ON ACTIVATED INFLAMMASOME IN MODELS OF NONALCOHOLIC FATTY LIVER DISEASE
Authors: H.J. Lee, J.E. Yeon, E.J. Ko, E.L. Yoon, S.J. Suh, K. Kang, H.R. Kim, S.H. Kang, Y.J. Yoo, J. Je, J.H. Kim, Y.S. Seo, H.J. Yim, S.H. Um, K.S. Byun
Journal: Journal of Hepatology (2014)
Who should provide research initiative and support?
Authors: L H Kuller
Journal: Environmental Health Perspectives (1981)

The study of low dose environmental exposure is a major concern for epidemiologists. The problem is a special example of a common source epidemic with either single or continuous exposure. Usually the most common source investigations begin with an epidemic, cluster of cases. However, environmental studies often start with an exposure that is considered to be potentially hazardous and a search for cases. The relatively low attack rate and also relative risk requires large sample sizes for testing hypotheses. The incubation period from exposure to onset of the disease may be very long, and therefore the exposure dose is difficult to define. Many of the diseases of interest also have multiple etiologies, and the amount of disease attributed to the specific environmental exposure may be relatively small (the attributable risk). Many of the other potential etiological agents also share common host characteristics with the environmental agent of interest further confounding the analysis. The identification of specific, unusual characteristics of disease such as rare histological type or location, or host characteristic may be a valuable approach to the study of environmental agents. The cost of doing environmental studies are substantial. Various resources are currently being utilized. There are several problems associated with many of these nongovernmental resources. One possible solution to the availability of a large funding source for environmental research, independent of special interest groups, may be a consumer-oriented tax on adverse personal health behavior, such as alcohol consumption and cigarette smoking.
Survivors' Congress Promotes Cancer Research
Authors: K. Nagy
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Survivors' Congress Promotes Cancer Research Get access Kate Nagy Kate Nagy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 24, 20 December 1995, Pages 1834–1835, https://doi.org/10.1093/jnci/87.24.1834 Published: 20 December 1995
Abstract 2914: Mice deficient in Smurf2 exhibit increased spontaneous tumorigenesis
Authors: Hong Zhang, Charusheila Ramkumar
Journal: Cancer Research (2010)

Abstract Smurf2, a HECT family E3 ubiquitin ligase has been shown to ubiquitinate and target for degradation of several proteins that promote tumorigenesis, including TGF-β receptors, Smad2/3, β-catenin, and Mad2. Furthermore, we have previously found that Smurf2 can induce senescence in early passage cells in culture. As senescence has been postulated to act as a tumor suppression mechanism, we hypothesize that Smurf2 functions as a tumor suppressor. To test this hypothesis, we generated a Smurf2-deficienct mouse strain using a gene trapping strategy, in which transcription of Smurf2 is compromised. The homozygous Smurf2-deficient mice were obtained with the expected Mendelian ratio after intercrossing of heterozygous mice, and they exhibited no obvious developmental defects. Analysis of mouse embryonic fibroblasts from these Smurf2-deficient mice revealed that they exhibited delayed senescence entry and consequently had an increased tendency to become immortalized in culture. Cohorts of Smurf2-deficient and wild-type mice were generated and monitored for spontaneous tumor development. In this ongoing study, 37% (13 out of 35) of the Smurf2-deficient mice, but none of the wild-type mice showed signs of morbidity after 14-month of age. The moribund Smurf2-deficient mice were found to have enlarged spleen, pale kidneys and liver, and/or enlarged lymph nodes. Histopathology analysis indicated that most of the tumors are lymphomas. In addition, adenocarcinoma of the small intestine was found in one Smurf2-deficient mouse. Collectively, our data suggest that Smurf2 is a tumor suppressor. Preliminary studies of the underlying molecular mechanism of tumorigenesis in Smurf2-deficient mice will be presented. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2914.
Malaria Chemoprophylaxis for the Traveler
Authors: Alastair J.J. Wood, David J. Wyler
Journal: New England Journal of Medicine (1993)

The growing popularity of travel to the tropics (more than 9 million tourists arrive in Africa each year and more than 32 million in Asia and the southwestern Pacific region1) is placing an increasing number of travelers at risk for acquiring malaria. The number of cases of imported malaria reported annually to health authorities (approximately 1000 in the United States and several thousand in Europe) underestimates the problem,2,3 in large part because it does not include travelers who become sick while abroad. Delayed diagnosis and inadequate treatment of imported cases of malaria caused by Plasmodium falciparum have resulted . . .
Chemotherapy Alone for Early-Stage Hodgkin's Lymphoma
Authors: David J. Straus
Journal: New England Journal of Medicine (2011)

Extensive radiation therapy was the first therapeutic advance in the treatment of early-stage Hodgkin's lymphoma. More recently, less extensive radiation therapy in combination with chemotherapy has resulted in the lowest reported rates of early relapse. The HD10 trial (ClinicalTrials.gov number, NCT00265018) of the German Hodgkin Study Group showed that among patients with very favorable stage I or II Hodgkin's lymphoma, the outcome in those who received only two cycles of chemotherapy with doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) plus involved-field radiation therapy in reduced doses was similar to the outcome in those who received four cycles of chemotherapy and involved-field . . .
IN VITRO DETECTION OF MELANOMA WITH I-125 IODOAMPHETAMINE (IMP), MoAb, Fab, F(ab′)2 FRAGMENTS AND MoAb “COCKTAILS”.
Authors: Romaine E. Saxton, Marvin B. Cohen, Leslie Yamada, Donald L. Morton
Journal: Clinical Nuclear Medicine (1986)

Saxton, Romaine E.; Cohen, Marvin B.; Yamada, Leslie; Morton, Donald L. Author Information
Neoplasms of the Hematopoietic System in Nonhuman Primates: Report of One Spontaneous Tumor and Two Leukemias Induced by Procarbazine&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Roger W. O'Gara, Richard H. Adamson
 4, Margaret G. Kelly, Dan W. Dalgard
Journal: JNCI Journal of the National Cancer Institute (1971)

Three neoplasms of the hematopoietic system in nonhuman primates are reported. A spontaneous reticulum cell sarcoma arose in an adult African green monkey (Cercopithecus aethiops), and myelogenous leukemias were induced in 2 female rhesus monkeys (Macaca mulatta) at ages 17 months and 5½ years after treatment with procarbazine hydrochloride. Transplantation of the reticulum cell sarcoma to progeny of the donor and the myelogenous leukemias to newborn rhesus monkeys was unsuccessful. No virus particles were detected by electron microscopy, and no viruses were isolated after tissue culture passage.
PROATHEROGENIC EFFECTS OF RENOVASCULAR HYPERTENSION ARE COMPLETELY RESOLVED AFTER REVERSAL TO NORMOTENSION IN MICE
Authors: Martin Mortensen, Line Nilsson, Tore Larsen, Eirild Espeseth, Marie Bek, Martin Bjørklund, Mette Hagensen, Anne Wolff, Ernst-Martin Füchtbauer, Ebbe Boedtkjer, Jacob Bentzon
Journal: Journal of the American College of Cardiology (2016)
LONG TERM SIGNIFICANCE OF HEART FAILURE COMPLICATING ACUTE MYOCARDIAL INFARCTION IN 11,185 PATIENTS FROM THE IMPROVED REDUCTION OF OUTCOMES: VYTORIN EFFICACY INTERNATIONAL TRIAL (IMPROVE-IT)
Authors: Michael G. Silverman, Christopher Cannon, Michael Blazing, Francois Mach, Jing Zhou, Andrew Tershakovec, Robert Giugliano
Journal: Journal of the American College of Cardiology (2016)
PD/PA VARIATION PREVALENCE AND 2-HOUR REPEATABILITY DURING FRACTIONAL FLOW RESERVE ASSESSMENT
Authors: Dimitrios Alexopoulos, Periklis Davlouros, Grigorios Tsigkas, Nikolaos Koutsogiannis, Athanasios Moulias, Stelios Armilagos, Paraskevi Salata, Marianna Leopoulou
Journal: Journal of the American College of Cardiology (2016)
SP0021 The Onset of RA: Disease Processes at Extraarticular Sites
Authors: A. Catrina
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease resulting from the complex interaction between genes and environment. In a large majority of patients this interaction leads to formation of anti-citrullinated proteins antibodies (ACPA), highly specific for RA. New insights in the early stages of disease development revealed a central role for ACPA immunity outside the joints and already before disease onset in the lungs, the gingival tissue and lymph nodes. In recent years most knowledge has been gained into the link between the lungs and the joints, suggesting a stepwise development of the disease, initiating in the lungs and ending up in the joints. According to this model smoking induces subclinical inflammation in the lungs, leading to increased local peptide citrullination and formation of ACPA in genetically susceptible individuals. These antibodies will than circulate in the blood of yet healthy individuals to finally localized in the joint when a yet unidentified second hit will promote citrullination of peptides identical to those existing in the lungs. These findings point to an early lung involvement in RA as a potential primary initiation site of the ACPA response. <h3>Disclosure of Interest</h3> None Declared
Phase I Study for Ceritinib (Ldk378) in Japanese Patients with Alk Genetic Alterations
Authors: H. Murakami, T. Seto, T. Takahashi, A. Horiike, F. Hirai, N. Suenaga, T. Tajima, K. Tokushige, A.L. Boral, M. Robson, M. Nishio
Journal: Annals of Oncology (2014)
Dysphagia caused by migrated mesh after paraesophageal hernia repair
Authors: Q. Arroyo, F. Argüelles-Arias, M. Jimenez-Saenz, J. Herrerias-Gutierrez, F. Pellicer Bautista
Journal: Endoscopy (2011)

Corrected by: Dysphagia caused by migrated mesh after paraesophageal hernia repairEndoscopy 2011; 43(S 02): E314-E314DOI: 10.1055/s-0030-1256866
Natural History of Lactic Acidosis after Grand-Mal Seizures
Authors: Carl E. Orringer, John C. Eustace, Christian D. Wunsch, Laurence B. Gardner
Journal: New England Journal of Medicine (1977)

Original Article from The New England Journal of Medicine — Natural History of Lactic Acidosis after Grand-Mal Seizures — A Model for the Study of an Anion-Gap Acidosis Not Associated with Hyperkalemia