tbuckley/cabot-search huggingface dataset:
Resistance to Penicillin and Cephalosporin and Mortality from Severe Pneumococcal Pneumonia in Barcelona, Spain
Authors: Roman Pallares, Josefina Liñares, Miquel Vadillo, Carmen Cabellos, Frederic Manresa, Pedro F. Viladrich, Rogelio Martin, Francesc Gudiol
Journal: New England Journal of Medicine (1995)

Penicillin-resistant strains of Streptococcus pneumoniae are now found worldwide, and strains with resistance to cephalosporin are being reported. The appropriate antibiotic therapy for pneumococcal pneumonia due to resistant strains remains controversial.
39 GENOME-WIDE ASSOCIATION STUDY IDENTIFIES NEW VARIANTS ASSOCIATED WITH THE RISK OF CHRONIC HEPATITIS B
Authors: H.Y. Kim, Y.J. Kim, J.-J. Yoo, M. Lee, Y.B. Lee, J.-H. Lee, S.J. Yu, J.-H. Yoon, H.-S. Lee, C.Y. Kim, J.Y. Cheong, S.W. Cho, N.H. Park, B.L. Park, S. Namgoong, L.H. Kim, H.S. Cheong, H.D. Shin
Journal: Journal of Hepatology (2013)
Albumin-Binding and Angiogenic Domains of SPARC Located at Its C-Terminus.
Authors: D. Knauer, L. Hwang, C. Lowe, J. Hwang, M. Norng, V. Trieu, N. Desai
Journal: Cancer Research (2009)

Abstract Background: SPARC (Secreted Protein Acidic and Rich in Cysteine) is an albumin-binding glycoprotein overexpressed in breast cancer and is associated with poor prognosis and shorter overall survival. We have previously shown that SPARC expression appeared to correlate with response to nanoparticle albumin-bound (nab) paclitaxel (Abraxane) in head-and-neck and pancreatic-cancer patients. To further define the role of SPARC, recombinant-human SPARC (rhSPARC) was characterized to identify its albumin-binding and angiogenic domain.Materials and methods: The albumin-binding site on SPARC was defined by testing the binding of Alexa 488-labeled BSA to immobilized rhSPARC in a solid-phase-binding assay and in a competitive-binding assay in presence of increasing concentration of various SPARC-derived peptides. The angiogenic activity of rhSPARC was evaluated using a HUVEC tube-formation assay.Results: The SPARC albumin-binding assay revealed a pattern of saturable and specific binding with an estimated Kd of 700 µM very near the known plasma concentration of albumin (600 µM). Competitive binding with Cathepsin K-digested SPARC and SPARC-derived peptides defined the albumin-binding domain to be amino acids 209-223 in the C-terminal region. In the HUVEC tube-formation assay, rhSPARC was pro-angiogenic at 10 µg/ml and anti-angiogenic at 100 µg/ml. The angiogenic domain of SPARC was located to the C-terminal of SPARC.Discussion: The albumin-binding domain of SPARC was located to residues aa209-223, supporting its role as a target for nab-technology-based drug delivery. We confirmed that SPARC can promote angiogenesis at physiological concentrations, contributing to the role of SPARC in a more aggressive tumor phenotype. The angiogenic domain of SPARC is located within a 54-aa sequence of its C-terminus. SPARC could be a potential therapeutic target and a biomarker for predicting response to nab-paclitaxel. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2144.
SP0194 Is Osteoarthritis an Inflammatory Disease?
Authors: F. Berenbaum
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Osteoarthritis has long been considered a "wear and tear" disease leading to loss of cartilage. OA used to be considered the sole consequence of any process leading to increased pressure on one particular joint or fragility of cartilage matrix. Progress in molecular biology in the 1990s has profoundly modified this paradigm. The discovery that many soluble mediators such as cytokines or prostaglandins can increase the production of matrix metalloproteinases by chondrocytes led to the first steps of an "inflammatory" theory. However, it took a decade before synovitis was accepted as a critical feature of OA, and some studies are now opening the way to consider the condition a driver of the OA process. Recent experimental data have shown that subchondral bone may have a substantial role in the OA process, as a mechanical damper, as well as a source of inflammatory mediators implicated in the OA pain process and in the degradation of the deep layer of cartilage. Thus, initially considered cartilage driven, OA is a much more complex disease with inflammatory mediators released by cartilage, bone and synovium. Low-grade inflammation induced by the metabolic syndrome, innate immunity and inflammaging are some of the more recent arguments in favour of the inflammatory theory of OA and will be highlighted in this lecture. <h3>Disclosure of Interest</h3> None Declared
Is it a mortgage? Is it a photocopier? No..
Authors: C. Douglas
Journal: BMJ (1996)

It's the private finance initiative: the current hot topic here in Auchendreich. While it is not the normal practice of the Auchendreich Medical Golf Society to disclose the minutes of the 19th hole meeting, it was agreed on Saturday that—in view of the seriousness of the problems faced and the lessons that might be learnt elsewhere—an exception might be made just once.

Though for more than 40 years the rebuilding of Auchendreich General has been among the highest priorities of public spending, it has to be acknowledged that, locally at least, there has been a strong sense of disappointment. Plans have …
PTU-218 Pilot randomised cross-over study comparing the efficacy of transnasal Endosheath® to standard endoscopy to detect Barrett's oesophagus
Authors: K M Shariff, S Verghese, M O'Donovan, Z Abdullahi, J Blazeby, R C Fitzgerald
Journal: Gut (2012)

<h3>Introduction</h3> A less expensive and safer alternative to standard sedated endoscopy (SE) needs to be considered as a screening method to detect Barrett9s oesophagus (BE) in the population, with the aim of reducing the mortality associated with oesophageal adenocarcinoma. The Endosheath® transnasal oesophagoscope (TNE) can potentially offer a new alternative to conventional standard endoscopy in diagnosing Barrett9s oesophagus. The Endosheath® technology uses a sterile, disposable sheath which covers the ultra thin flexible oesophagoscope and isolates it from the patient. The oesophagoscope is placed in a new sheath prior to each procedure which obviates the need for machine washing and permits a quick turnaround. <b>Aim:</b> A pilot study to evaluate the efficacy of TNE in diagnosing BE compared with SE and to assess patient acceptability of TNE. <h3>Methods</h3> Patients referred for surveillance endoscopy for BE or a clinically indicated routine endoscopy were recruited to both TNE and SE in a randomised cross-over design. The interval between the procedures was at least 6 weeks. TNE findings of endoscopic BE, and presence of intestinal metaplasia (IM) on the biopsy samples were compared against SE, which was used as gold standard. A 10-point visual analogue scale (0 represented the worst experience and 10 the best experience) to assess the post-endoscopy experience and a single question addressing preference for endoscopy type were used to measure patient acceptability of the procedures. <h3>Results</h3> 15 patients completed the study, 10 males and 5 females with a mean age of 62.85 years (range 50–76 years). Nine of which were BE surveillance patients and six were referred for a clinically indicated routine endoscopy. Eight patients were randomised to the SE as the first procedure. All the 11 patients with an endoscopic diagnosis of BE on SE were accurately identified with the TNE (sensitivity 100%; specificity 100%). Biopsies were taken in all the 11 Barrett9s segments except in one &lt;1 cm segment with TNE due to technical difficulty. IM was detected in 9 out of the 11 patients with BE on SE compared to 7 out of the 11 patients with BE on TNE (sensitivity 77.8%; specificity 100%). Patients reported significantly better experiences of endoscopy with TNE with scores of 6.9 (±0.81 SEM) compared with 3.7 (±0.37 SEM) for SE (p=0.001). Eight patients (53%) reported a preference for TNE compared with 1 (7%) for SE. <h3>Conclusion</h3> Endosheath® transnasal oesophagoscope is accurate in diagnosing endoscopic BE and can detect IM. It is better tolerated and preferred by patients, making it a useful screening tool for BE with potential for use in primary care. <h3>Competing interests</h3> None declared.
Abstract 1522: Spheroid formation causes a decrease in ovarian cancer cell growth rate that persists through dissociation and growth as a monolayer
Authors: Jillian C. Pease, Jennifer S. Tirnauer
Journal: Cancer Research (2011)

Abstract Ovarian cancer has the highest mortality of all cancers of the female reproductive system. It accounts for three percent of all cancers in women and is the fifth leading cause of cancer-related death among women in the United States. Ovarian cancer cells can metastasize to the uterus, fallopian tubes, and pelvis tissues as well as to other organs. Even with optimal treatment there is a high probability that the cancer will recur, suggesting that current treatments are not successful in eliminating all of the ovarian cancer cells. This may be a result of a protective mechanism of the ovarian cancer cells. Spheroids are large collections of cancer cells that adhere tightly to each other rather than spreading out across an underlying basement membrane. They have been observed in ovarian cancer both in vivo and in ovarian cancer cell lines. Spheroids have been shown to play a role in the metastasis of ovarian cancer cells and have also been shown to be drug resistant. It is our hypothesis that spheroid formation results in epigenetic changes promoting the survival of ovarian cancer cells. Our data suggests that spheroid growth causes the growth rate of ovarian cancer cells to decrease and remain decreased following the transition from spheroids back to monolayer culture. Furthermore, serial passaging of ovarian cancer spheroids results in an increase in resistance to cytotoxic drugs. Since the decrease in growth rate appears to be persistent after spheroid culture it is likely the result of epigenetic modifications that occur during spheroid formation. These epigenetic changes, currently being studied, could become potential drug targets, as new treatments are developed to not only kill ovarian cancer cells but also prevent spheroid formation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1522. doi:10.1158/1538-7445.AM2011-1522
UTILIDAD DE LAS PROTESIS AUTO-EXPANDIBLES EN EL TRATAMIENTO DE LAS DEHISCENCIAS DE SUTURA DE ANASTOMOSIS ESOFAGO – GASTRICAS DE CAUSA NEOPLASICA
Authors: M Alburquerque, F Mohamed, P Planellas, M Figa, J Roig, F González-Huix
Journal: Endoscopy (2011)

Introducción: La dehiscencia de sutura esofágica (DSE) se asocia a una elevada morbimortalidad. Las prótesis auto-expandibles (PE) son una alternativa en su tratamiento.
Abstract 3265: PMA induces malignant characteristics in MCF-7 breast cancer cells via MAPK-pathway
Authors: Laura C. Hautala, Riitta Koistinen, Hannu Koistinen
Journal: Cancer Research (2012)

Abstract Phorbol 12-myristate 13-acetate (PMA) is a well known tumor promoter, the effect of which is mainly mediated by protein kinase C (PKC). The effect of PMA varies depending on the cell line and growth conditions. In MCF-7 breast cancer cells PMA has been found to induce growth arrest and resistance to apoptosis. Here, we studied the effects of PMA on differentiation and malignant characteristics of MCF-7 cells. The cells were grown on Matrigel besement membrane preparation or on plastic/glass surface with and without PMA, rottlerin or bryostatin. The cell proliferation assay was carried out using the cells grown on 96-well plates. Wound healing test, on glass surface, was used to detect the differences in cell migration. Activation of MAPK-pathway proteins was studied with Phospho-kinase array. When grown on Matrigel, the addition of PMA to cell culture medium increased the motility of the cells and induced dramatic morphological changes, leading to the formation of web-like multicellular structures. These changes were not observed when the cells were grown on plastic or glass surface. However, PMA caused a two-fold increase in the migration of the cells on glass surface. Furthermore, the PMA treated cells had lower proliferation rate than the untreated cells. Preincubation of the cells with PKC-inhibitors rottlerin or bryostatin abolished the effects of PMA, suggesting that these effects are mediated by PKC. PMA also induced several changes in the phosphorylation of different proteins involved in MAPK-pathway. Our results confirm the previous findings showing that PMA induces malignant characteristics in MCF-7 breast cancer cells. Morphological differentiation was only seen when the cells were grown on basement membrane preparation, recapitulating the physiological growth environment of the cells better than the artificial plastic surface. Furthermore, our results indicate that the effects of PMA on MCF-7 cells are mediated by MAPK-pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3265. doi:1538-7445.AM2012-3265
Surgical removal of a severed Dormia basket from the bile duct
Authors: Rudolf García-Gallont, Jose Velasquez, W. Duarte
Journal: Endoscopy (2014)

A 63-year-old man, with a body mass index of 32 kg/m2, was admitted with obstructive jaundice due to cholecysto-choledocholithiasis. He was febrile and had had subcostal pain for at least 3 weeks. Endoscopic retrograde cholangiopancreatography (ERCP) confirmed the presence of stones in the common bile duct (CBD). Papillotomy was carried out and stone retrieval commenced with a Dormia basket. One stone became entrapped in the Dormia basket and it was impossible to remove it through the papilla. A Soehendra mechanical lithotripsy device was advanced over the Dormia basket with the intention of fragmenting the stone. However, the stone did not fracture on application of force ([Fig. 1]). On increase of the level of force applied, the Dormia basket deformed ([Fig. 2]) and eventually fractured, with its tip and the embedded stone remaining in the distal CBD.
Morphogenesis of Experimental Tumors of the Esophagus
Authors: Nikolai P. Napalkov, Kazymir M. Pozharisski
Journal: JNCI Journal of the National Cancer Institute (1969)

In 42 rats, tumors of the esophagus were induced with N-methyl-N-nitrosoaniline. According to the data, morphogenesis of experimental esophageal carcinomas begins with diffuse hyperplastic changes in the epithelium (acanthosis). These changes accompanied by hyperkeratosis and parakeratosis result in the formation of foci of leukoplakia. Hypertrophy and proliferation of the connective tissue papillae beneath the foci of leukoplakia cause development of the verrucose lesions designated leukokeratosis. Subsequent polypoid outgrowths of the altered mucosa form papillomas. Finally, some papillomas progress to carcinoma.
AORTIC VALVE GRADIENT AND CLINICAL OUTCOME IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT FOR SEVERE AORTIC STENOSIS
Authors: Guy Witberg, Alon Barsheshet, Hana Vaknin-Assa, Abid Assali, Yaron Shapira, Tuvya Ben-Gal, Alik Sagie, Ran Kornowski
Journal: Journal of the American College of Cardiology (2016)
Assessment of Genetic Alterations in Postmenopausal Women with Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer from the BOLERO-2 Trial by Next-Generation Sequencing
Authors: M. Piccart, H. Rugo, D. Chen, M. Campone, H.A. Burris, T. Taran, T. Sahmoud, I. Deleu, G. Hortobagyi, J. Baselga
Journal: Annals of Oncology (2013)
Abstract 2060: Comprehensive multiparametric assay of hypoxia and reactive oxygen species in live cells using different instrumentation platforms
Authors: Irina V. Lebedeva, Maciej Szczepanik, Praveen Pande, Wayne F. Patton
Journal: Cancer Research (2011)

Abstract Hypoxia is a pathological condition in cells and tissue arising from oxygen deprivation. Cancer-associated hypoxia has been linked to drug treatment resistance, increased cell proliferation and metastatic potential, which overall contributes to poor patient prognosis. Many of the cellular responses to hypoxia are now known to be mediated by the production of reactive oxygen species at mitochondrial complex III. The importance of the maintenance of cellular oxygen supply requires further investigation into the role of ROS as hypoxia signaling molecules. Despite sustained interest in the association between hypoxia, ROS production and disease, methods for conveniently and reliably identifying and quantifying hypoxic cells as well as redox status in patients have remained elusive. We designed and synthesized a series of non-fluorescent or weakly fluorescent aromatic compounds that become fluorescent once activated by hypoxic conditions. The probes were validated using a variety of in vitro cell-based hypoxia model systems involving exposure to hypoxia-inducing compounds (CoCl2, desferrioxamine or dimethyloxalylglycine) or by incubation in an anoxic environment (95% N2, 5% CO2). In the in vitro cell-based hypoxia model systems, all tested probes exhibited strong fluorescent cytoplasmic signal, readily detectable by different instrumental platforms. For the real-time profiling of both hypoxic and redox cellular status, these self-immolative hypoxia probes were combined with various ROS detection probes and stained samples were analyzed using conventional fluorescence microscopy or flow cytometry. The described assay workflow facilitates rapid, reproducible, specific and relatively simple functional and quantitative detection of cellular oxygen status in a real-time format, and can readily be implemented on widely available instrumentation. The assay may be applicable to the screening of putative modulators of hypoxia or ROS production. Profiling of ROS is also possible when specific inhibitors of ROS are implied. The outlined fluorescence detection method offers an attractive approach for studying hypoxia and ROS pathways in a noninvasive manner, providing the ability for spatial and temporal resolution of cellular signaling events. The described multiparameter assay should find use in diverse applications relating to detection, quantification and localization of hypoxic cells in vivo and in vitro, as tools for the development of predictive assays or possibly as biosensors for early treatment monitoring and validation of potential endogenous hypoxia biomarkers and signaling molecules. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2060. doi:10.1158/1538-7445.AM2011-2060
Uptake of Ga-67 in Granulomatous Myositis with Magnetic Resonance Imaging Correlation
Authors: LEONIE GORDON, JASON R. HOSEY, TIMOTHY SLOAN
Journal: Clinical Nuclear Medicine (2001)

From the Department of Radiology, Medical University of South Carolina, Charleston, South Carolina Received for publication January 3, 2001. Accepted January 31, 2001. Reprint requests: Leonie Gordon, Medical University of South Carolina, Department of Radiology, 169 Ashley Avenue, P.O. Box 250322, Charleston, South Carolina 29425. E-mail: [email protected]
THU0304 Epidemiological Study of Hospitalized Patients Infection in Rheumatology
Authors: Y. Lei, L. Riqiang, Z. Xiao
Journal: Annals of the Rheumatic Diseases (2014)

Background To study the epidemiological characteristics of 6307 cases of rheumatism patient's hospitalized infection in rheumatology in 2006-2011, study the prevalence of infection and the characteristics of rheumatology patients, and to analyze the influencing factors. Objectives To study the epidemiological characteristics of 6307 cases of rheumatism patient's hospitalized infection in rheumatology in 2006-2011, study the prevalence of infection and the characteristics of rheumatology patients, and to analyze the influencing factors. Methods Retrospective analysis the data of 6307 cases of patients in rheumatology in 2006-2011 who admitted to our hospital, analysis of various types of epidemiological characteristics in 1137 cases of infection, analysis of the incidence differences in different years and months and seasons, and analysis of the infection incidence difference of risk factors, and analysis of infection site differences. Results Over the analysis of the incidence of infection in different years, the incidence of infection in 2010 was the most (40.89%). The high incidence of infection of the month was 4,5,6, concentrated in spring and summer (21.44% incidence, 20.16%). Infection group's age (43.11±18.86) and length of stay (12.82±10.88) were higher than non-infected group (40.37±18.52, 9.99±12.39), and the percentage of women infected group (68.69%) was more than non-infected group (64.18%), the odds ratio (OR) was 1.225. Study the site of infection, lung and kidney infection rate was the highest (26.47%, 17.68%). Tuberculosis infection in patients with younger, male-dominated and most happen in lung, and fungal infections in patients with age generally higher, mostly women and mostly associated with multiple infections and happen in mouth. Conclusions The risk factors for infection in rheumatology are spring and summer, older age, long hospital stay, women, etc., should pay attention to the associated protective measures to reduce the incidence of infection. Disclosure of Interest : None declared DOI 10.1136/annrheumdis-2014-eular.3972
Cutting Edge Meets Clinic in Treatment Research
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Cutting Edge Meets Clinic in Treatment Research Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 24, 21 December 1994, Pages 1818–1820, https://doi.org/10.1093/jnci/86.24.1818 Published: 21 December 1994