tbuckley/cabot-search huggingface dataset:
Mammalian Chromosomes &lt;italic&gt;In Vitro&lt;/italic&gt;. VIII. Heteroploid Transformation in the Human Cell Strain Mayes&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: T. C. Hsu, C. M. Pomerat, Paul S. Moorhead
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Mammalian Chromosomes In Vitro. VIII. Heteroploid Transformation in the Human Cell Strain Mayes Get access T. C. Hsu, T. C. Hsu University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas, and University of Texas Medical Branch, Galveston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar C. M. Pomerat, C. M. Pomerat University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas, and University of Texas Medical Branch, Galveston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul S. Moorhead Paul S. Moorhead University of Texas M. D. Anderson Hospital and Tumor Institute, Houston, Texas, and University of Texas Medical Branch, Galveston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 5, November 1957, Pages 867–873, https://doi.org/10.1093/jnci/19.5.867 Published: 01 November 1957 Article history Received: 10 May 1957 Published: 01 November 1957
Impact of DSM-III on clinical practice
Authors: T J Craig, A B Goodman, G Haugland
Journal: American Journal of Psychiatry (1982)

The authors compared criterion-based diagnoses (DSM-III) with clinical diagnoses (DSM-II) for 102 psychiatric inpatients. The introduction of specified diagnostic criteria represented a refinement of existing diagnostic practices rather than a qualitatively different approach to diagnoses; however, in the schizophrenia and affective disorder categories, nonwhites and women were more often assigned to worse prognostic category by the DSM-II system than were white men with similar symptoms. The authors suggest that the introduction of DSM-III criteria may ensure more appropriate diagnosis and treatment for nonwhites and women.
SAT0286 Monthly Ibandronate Reduces Bone Loss in Osteopenic Women with Rheumatoid Arthritis Receiving Long-Term Glucocorticoids: A 48-Week Double-Blinded Randomized Placebo-Controlled Investigator-Initiated Trial
Authors: K. Shin, S.-H. Park, W. Park, H.-J. Baek, Y.-J. Lee, S.-W. Kang, J.-Y. Choe, W.-H. Yoo, Y.-B. Park, J.-S. Song, B. Yoo, D.-H. Yoo, Y.W. Song
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Long-term use of glucocorticoids (GC) is problematic for patients with increased risk for vertebral fractures, especially those with rheumatoid arthritis (RA). Thus, prevention of GC-induced osteoporosis (GIOP) with bisphosphonates has now become an important strategy for reducing morbidity in RA patients. Ibandronate is indicated for the treatment and prevention of osteoporosis in postmenopausal women. However, evidence for ibandronate in GIOP prevention has been insufficient to date. <h3>Objectives</h3> To investigate efficacy of monthly ibandronate in RA women with reduced bone mineral density receiving long-term GCs <h3>Methods</h3> Female RA patients meeting the 1987 ACR classification criteria were enrolled in this 48-week double-blinded randomized placebo-controlled trial (clinicaltrials.gov NCT01287533). Patients that had taken GC (prednisolone-equivalent dose of ≥5 mg) for 3 or more consecutive months and fulfilling L1-4 T-score of &lt; -1.0 and ≥ -2.5 by dual-energy X-ray absorptiometry were enrolled in this study. Patients were divided into 2 groups: 150 mg ibandronate versus placebo po every 4 weeks. Both groups were provided with daily 1500 mg of calcium carbonate and cholecalciferol of 400 IU. The primary end point was to compare the % changes of the L1-4 T-score at 48 weeks compared with baseline. <h3>Results</h3> Two hundred eleven patients from 13 centers nationwide participated in this study. One hundred sixty seven patients were randomized. The mean age of patients in the ibandronate and placebo group were 54.5 and 55.1 years, respectively. Baseline characteristics were not dissimilar between the 2 groups. The result of the primary endpoint is shown below (table). Serum C-terminal telopeptide was significantly reduced at 48 weeks in the ibandronate group. There was no incident of fracture in both groups during the study period. Safety profiles including adverse events were comparable between the 2 groups. <h3>Conclusions</h3> Monthly ibandronate for 48 weeks is effective in reducing bone loss in RA women on long-term glucocorticoids. Longer follow-up studies would be needed to investigate the effect on fracture prevention. <h3>Acknowledgements</h3> We would like to thank CTC bio for manufacturing the placebo, and Mr. Je-suk Kim for aiding statistical analyses. <h3>Disclosure of Interest</h3> None declared
Origin and Behavior of Two Transplantable Lymphomas Induced by X Radiation
Authors: Emma Shelton
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Origin and Behavior of Two Transplantable Lymphomas Induced by X Radiation Get access Emma Shelton Emma Shelton National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1203–1223, https://doi.org/10.1093/jnci/12.6.1203 Published: 01 June 1952 Article history Received: 23 January 1952 Published: 01 June 1952
THU0620-HPR Cross-Cultural Adaptation, Reliability and Validity of the Turkish Version of the Spine Functional Index
Authors: E. Tonga, P.C. Gabel, S. Karayazgan, A. Cuesta Vargas
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Spine Functional Index (SFI) is a patient reported outcome measure with sound clinimetric properties and clinical viability for determination of whole-spine impairment. To date, no validated Turkish version is available. <h3>Objectives</h3> The purpose of this study is to cross-culturally adapted the SFI for Turkish-speaking patients (SFI-Tk) and determine the psychometric properties of reliability, validity and factor structure in a Turkish population with spine problems. <h3>Methods</h3> The SFI English version was culturally adapted and translated into Turkish using a double forward and backward method according to established guidelines. Patients (n=l32 neck region, n=153 low back region, 73% female, age 45±1) with spine disorders completed the SFI-Tk at baseline and after a seven day period for test-retest reliability. For criterion validity the Turkish version of the Functional Rating Index (FRI) was used plus the Neck Disability Index (NDI) and the Oswestry Disability Index (ODI) for back patients. Additional psychometric properties were determined for internal consistency (Chronbach9s α), criterion validity and factor structure. <h3>Results</h3> There was a high degree of internal consistency (α=0.85, item range 0.80-0.88). The test-retest reliability was high (r=0.93,item range 0.75-0.95). The factor analysis demonstrated a one-factor solution explaining 24.2% of total variance. Criterion validity with the ODI was high (r=0.71, p&lt;0.001), with FRI and NDI it was fair (r=0.52 and r=0.58, respectively). The SFI-Tk showed no missing responses with the “half-mark” option used in 11.75% of total responses by 77.9% of participants. Measurement error from SEM and MDC<sub>90</sub> were respectively 2.96% and 7.12%. <h3>Conclusions</h3> The SFI-Tk demonstrated a one-factor solution and is a reliable and valid instrument. The SFI-Tk consists of simple and easily understood wording and may be used to assess spine region musculoskeletal disorders in Turkish speaking patients. <h3>References</h3> Gabel CP, et al: The Spine Functional Index: development and clinimetric validation of a new whole-spine functional outcome measure. Spine J, 2013. Cuesta-Vargas AI, Gabel PC. Validity of the Spanish version of the spine functional index. Health Qual Life Outcomes, 2014 Jun 27;12:96. doi: 10.1186/1477-7525-12-96. Beaton DE, et al: Guidelines for the process of cross-cultural adaptation of self-report measures. Spine (Phila Pa 1976), 2000, 25(24): 3186-91. Mokkink LB, et al: The COSMIN study reached international consensus on taxonomy, terminology, and definitions of measurement properties for health-related patient-reported outcomes. J Clin Epidemiol, 2010, 63(7): 737-45. <h3>Disclosure of Interest</h3> None declared
FRI0200 Association of Serum DKK-1 and Sclerostin Levels with Acute Phase Reactants and Clinical and Radiographic Variables in Patients with Ankylosing Spondylitis
Authors: G.T. Sakellariou, M. Konsta, C. Berberidis, A. Iliopoulos
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To investigate the relationship of serum Dickkopf-1 (Dkk-1) and sclerostin levels with acute phase reactants and clinical and radiographic parameters in patients with ankylosing spondylitis (AS). <h3>Methods</h3> This was an observational, cross-sectional study. Serum samples for total Dkk-1 and sclerostin were obtained from 65 tumour necrosis factor (TNF) inhibitor naïve patients with AS according to the modified New York criteria [mean age 41.3 years (S.D. 12.0); duration of symptoms 13.4 years (S.D. 10.0); male gender 61 patients (93.8%)]. The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), Bath AS Disease Activity Index (BASDAI), Bath AS Functional Index (BASFI) and modified Stroke AS Spine Score (mSASSS) were assessed for each patient. Subgroups were created by splitting ESR, CRP and BASDAI at predefined values considered as elevated for acute phase reactants and representing high and low disease activity for the BASDAI. ESR of 20mm/h, CRP levels of 5mg/l and BASDAI score of 40 were used as cutoff points. <h3>Results</h3> Dkk-1 levels were significantly higher in patients with elevated ESR (p=0.009) and CRP (p=0.017) compared with those without (Table 1). Furthermore, Dkk-1 (p=0.005) and sclerostin (p=0.025) levels were significantly lower in patients with at least one syndesmophyte compared with those without. Dkk-1 levels were correlated negatively with age (r= −0.281, p=0.024), duration of symptoms (r= −0.282, p=0.023) and mSASSS (r= −0.253, p=0.042), and positively with sclerostin (r=0.557, p&lt;0.001); and sclerostin levels were correlated negatively with age (r= −0.317, p=0.01) and mSASSS (r= −0.226, p=0.04), and positively with Dkk-1. <h3>Conclusions</h3> Besides the negative association of serum Dkk-1 and sclerostin with radiographic damage, which is in accordance with the results of previous studies in AS, we found higher Dkk-1 levels in patients with elevated acute phase reactants, suggesting that the link between inflammation and systemic bone loss (osteoporosis) in AS could also be explained by the osteoblast inhibition through Wnt pathway, along with the osteoclast activation by pro-inflammatory cytokines like TNF. Thus, serum concentrations of Dkk-1 are appeared to relate not only to the specific anabolic process of syndesmophyte formation but also to the inflammation that affects the general bone remodeling. <h3>Disclosure of Interest</h3> None declared
Intractable infertility
Authors: A. Bagshawe
Journal: BMJ (2003)

It is rare for any of the options available for couples with intractable infertility to be seen as a first choice.For many couples in this situation infertility is like bereavement and causes great emotional distress.However, with help, people may be able to accept their position and see the opportunity to start a new life.To embrace any of the following options and to cope with the complications and frustrations of each, psychological strength and stamina are needed, plus help from a skilled independent counsellor. Egg, sperm, and embryo donationCounselling for gamete and embryo donation Counselling for those receiving donor gametes or embryos encourages them to explore concerns and feelings related to their infertility before considering the social and emotional issues that may arise from non-genetic parenthood.The emotional impact and implications of donation can cause problems for recipients.Men and women often have different thoughts and feelings about the donors and about accepting donated gametes or embryos.Short and long term implications of donation are influenced by the attitude, beliefs, and personal and social situation of the individuals concerned.Sperm, egg, and embryo donation can be from an anonymous or a known donor, and each has different implications.Counselling can be relatively straightforward or complex depending on the circumstances, and the counselling sessions will vary in length and intensity accordingly.Counselling explores the implications of a person's reasoning and challenges their assumptions and preconceptions.Issues such as openness or secrecy must be considered, as well as the questions of whether to tell the potential future child about their genetic background, and what, how, and when to tell both the child and the wider family.
A dynamic landscape of allergen associations in delayed‐type cutaneous hypersensitivity
Authors: M.D. Lynch, J.M. White, J.P. McFadden, Y. Wang, I.R. White, P. Banerjee
Journal: British Journal of Dermatology (2016)

Delayed-type hypersensitivity represents a significant clinical and public health challenge. Patients undergoing patch testing may exhibit positive reactions to more than one allergen. It is recognized that reactions to specific pairs of allergens are associated, reflecting a combination of exposure patterns and structural similarity.To explore the influence of time of testing, age, sex and atopy status on allergen pair associations in a series of 45 110 consecutive patients tested over 30 years.Patch test records of all patients undergoing testing with a modified European baseline series between 1985 and 2014 were retrieved from a database at St John's Institute of Dermatology. Reactions were read on days 2 and 4. For each allergen it was recorded whether the allergen was tested and whether the result was positive or negative.This is the largest reported study of patch test allergen pair relationships. Our analysis shows a high degree of variability in allergen pair associations. Rigorous statistical analysis reveals a large number of differences between groups, including a significant increase in the association between formaldehyde and multiple formaldehyde-releasing preservatives over the study period, in addition to pair associations with cobalt and formaldehyde-releasing preservatives. These were present to a significantly greater extent in men than in women.These observations extend our understanding of cutaneous allergy, with implications for both clinical practice and mechanisms of cutaneous hypersensitivity.
AB0550 Experience on Influenza and/ or Pneumococcal Vaccination Among Filipino Patients with SLE in a Tertiary Care Hospital
Authors: A.T.S. Hernandez, M.L. Tee, A.D. Corpuz, J.L. Hipe, K.D. Tee
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic Lupus Erythematosus is an autoimmune disease, characterized as being in activity or remission. At present, various strategies and treatment options are well- recognized for improved patient management and disease control. Vaccination with the influenza and pneumococcal vaccines has been supported in studies worldwide. Despite this recommendation, several researches have documented the development of disease flares in patients with autoimmune diseases, and occurrence of a new autoimmune illness in previously healthy subjects, after vaccination. <h3>Objectives</h3> To report on the experience of influenza and/ or pneumococcal vaccinations in Filipino SLE patients at the Philippine General Hospital <h3>Methods</h3> The study was a descriptive study, collected retrospectively through chart reviews done at the Adult Rheumatology Clinic of the Philippine General Hospital. A total of 31 patients were included in the study. Records of the subjects were reviewed 8 weeks post- vaccination. Adverse reactions were noted. In addition, MEX-SLEDAI at baseline was compared to the score 8 weeks post- vaccination. <h3>Results</h3> Thirty- one patients were included in this study. All patients were females. Approximately 80% reported no lupus activity at baseline. Most patients were on multiple drug therapy with low- dose prednisone and an anti- malarial. Eight out of 31 patients had fever, site irritation, and GI disturbance. Out of the 31 patients, 33% developed an increase in MEX- SLEDAI from baseline, with activity mostly comprising of cutaneous and nephritic manifestations. Non- compliance to medications and sun exposure were the factors identified in the development of the flares. <h3>Conclusions</h3> Adverse reactions were noted in a small number of patients.Although 33% developed an increase in MEX- SLEDAI from baseline, these increases in baseline disease activity were noted to be multifactorial and could not be fully attributed to vaccination alone. However, despite such reactions and increases in MEX- SLEDAI, influenza and pneumococcal vaccination still appear to be well – tolerated among SLE patients. <h3>References</h3> Barber C, Gold W, Fortin P. Infections in the lupus patient: Perspectives on prevention. Current Opinion in Rheumatology 2012; 51: 1061- 1069. Milanovic M, Stojanovich L, Djokovic A. Influenza vaccination in auroimmune rheumatic disease patients. Tohoku J Exp Med 2013; 229: 29- 34. Crowe S, Merill K, Vista E, Dedeke A, et al. Influenza vaccination responses in human systemic lupus erythematosus: Impact of clinical and demographic features. <h3>Disclosure of Interest</h3> None declared
Adjuvant therapy of osteosarcoma.
Authors: J R Bertino
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.6.831 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3295126 Adjuvant therapy of osteosarcoma. J R BertinoxJ R BertinoSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.6.831 PDF "Adjuvant therapy of osteosarcoma.." Journal of Clinical Oncology, 5(6), pp. 831–832© 1987 by American Society of Clinical Oncology
Insulin levels during lactate infusion
Authors: J M Gorman, M R Liebowitz, J Stein, A J Fyer, D F Klein
Journal: American Journal of Psychiatry (1984)

To determine whether the lactate-induced panic of patients with panic attacks results from hyperinsulinism balanced by epinephrine-enhanced gluconeogenesis, the authors measured 10 subjects' insulin levels exactly when the lactate-induced attacks began. The insulin levels were normal.
AB0885 The Burden of Osteoporotic Hip Fractures in Portugal: Costs, Quality of Life and Mortality
Authors: A.A. Marques, Ó. Lourenço, J.A. Pereira da Silva
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteoporotic fractures represent a remarkable burden to health care systems and societies worldwide, which will tends to increase as life expectancy expands and life style changes favour osteoporosis (1). The cost-effectiveness evaluation of intervention strategies demands accurate data on the epidemiological and economical reality to be addressed (2). <h3>Objectives</h3> To estimate the overall societal cost of hip fractures, the per-patient costs and the impact on quality of life in Portugal, based on real-life individual patient data. <h3>Methods</h3> Information was collected on consumption of health resources, quality of life and mortality regarding 186 patients randomly selected to represent the distribution of hip fractures in the Portuguese population, in terms of gender, age and geographical provenience. Data were cross-tabulated with socio-demographic variables and individual resources consumption to estimate the burden of disease. A societal perspective was adopted, including direct and indirect costs. Multivariate analyses were carried out to assess the main determinants of Heath-related Quality of Life. <h3>Results</h3> Mean individual fracture-related costs were estimated at € 13,434 for the first year and € 5,985 for the second year following the fracture. In 2011 the economic burden attributable to osteoporotic hip fractures in Portugal could be estimated at € 216. Mean reduction in quality of life 12 months after fracture was estimated at 0.34. Regression analysis showed that age was associated with a higher loss of HrQoL, whereas education had the opposing effect. We observed an excess of 12% in mortality in the 2 first year after hip fracture, when compared to the gender and age-matched general population. <h3>Conclusions</h3> Results of this study indicate that osteoporotic hip fractures are associated with a high societal burden, in terms of costs, loss in quality of life and mortality. These data provide valuable input to the design and selection of fracture prevention strategies. <h3>References</h3> Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, et al. Osteoporosis in the European Union: medical management, epidemiology and economic burden. A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Archives of osteoporosis. 2013;8(1-2):136. Johnell O. The socioeconomic burden of fractures: today and in the 21st century. The American journal of medicine. 1997;103(2a):20S-5S; discussion 5S-6S. <h3>Disclosure of Interest</h3> None declared