tbuckley/cabot-search huggingface dataset:
The Complexities of Conducting Research on Child Trafficking
Authors: Jonathan Todres, Leslie E. Wolf
Journal: JAMA Pediatrics (2016)

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The Dose-Match Interaction in Umbilical Cord Blood (UCB) Transplantation: An Analysis of the Impact of Cell Dose and HLA-Match on the Disease-Free Survival (DFS) of 989 Patients Transplanted with Single Units for Hematologic Malignancy.
Authors: Juliet N. Barker, Andromachi Scaradavou, Cladd Stevens, Pablo Rubinstein
Journal: Blood (2007)
A Phase I-II Pilot Study of Divalproex Sodium Alone and in Combination with All-Trans-Retinoic Acid (ATRA) in Relapsed or Refractory Acute Myeloid Leukemia.
Authors: Janice L. Gabrilove, Melanie-Jane McConnell, Windy Berkofsky-Fessler, Andres L. Sirulnik, Sanjay Sharma, Lewis R. Silverman, Luis Isola, John Mandeli, Jonathan Licht
Journal: Blood (2005)
Immunologically-Selected Hematopoiesis Caused by HLA Allelic Loss In Patients with Aplastic Anemia
Authors: Takamasa Katagiri, Aiko Matsubara, Koichi Kashiwase, Motohiro Kato, Yasuo Morishima, Kohei Hosokawa, Shigeki Ohtake, Seishi Ogawa, Shinji Nakao
Journal: Blood (2010)
Treatment Patterns and Healthcare Costs in Newly Diagnosed Patients with Chronic Myeloid Leukemia Receiving Dasatinib or Nilotinib As First-Line Therapy in the United States: A Retrospective Claims Database Analysis
Authors: Lei Chen, Dominick Latremouille-Viau, Annie Guerin, Roy Nitulescu, Patrick Gagnon-Sanschagrin
Journal: Blood (2015)
Autologous Stem Cell Transplantation and Rituximab for Mantle Cell Lymphoma.
Authors: Francisco Javier Capote, E. González-Barca, J.M. Bergua, M.J. Pascual, R. García-Boyero, J.M. Ribera, A. Jiménez, A. Romero, P. Giraldo, J. Fernández-Calvo, J. Ramírez, M.L. Amigo, M.I. Muñoz, D. Caballero, M. Guinot, A. Oriol, J.A. Queizán, A. Cantalapiedra, J.M. Moraleda, C. Grande, L. Palomera, M. Almagro, A. Leon, A. Fernández-Sevilla, J.L. Gil
Journal: Blood (2005)
Epidemiology Of Invasive Aspergillosis (IA) During Induction Therapy In Adults With Acute Lymphoblastic Leukemia (ALL): A Graall-2005 Study
Authors: Clara Mariette, Anne Thiebaut, Jean-Yves Cahn, Didier Hocquet, Agnes Huynh, Françoise Isnard, Faezeh Legrand, Véronique Lhéritier, Emmanuelle Tavernier, Emmanuel Raffoux, Norbert Ifrah, Aline Schmidt, Herve Dombret
Journal: Blood (2013)
B-Cell Receptor Signaling Suppresses TAp63-Induced Apoptosis Via PI3-K/mTOR Pathway and Upregulation of MiR-21 in Chronic Lymphocytic Leukemia (CLL)
Authors: Leigh Ann Humphries, Darcy Bates, Claire Godbersen, Prabhjot Kaur, Alexey V. Danilov
Journal: Blood (2012)
Post-Transplant Therapy Is More Important Than Induction Regimen Choice in Autologous Hematopoietic Cell Transplantation (AHCT) Recipients for Multiple Myeloma (MM)
Authors: Robert Frank Cornell, Luciano J Costa, Adetola A. Kassim, Racquel Inns-Shelton, Amrita Krishnan, Tomer Mark, Yago Nieto, Cristina J Gasparetto, Anita D'Souza, Parameswaran Hari, Mei-Jie Zhang, Jiaxing Huang
Journal: Blood (2015)
Differential Patterns of Impaired Cardiorespiratory Fitness and Cardiac Autonomic Dysfunction in Recently Diagnosed Type 1 and Type 2 Diabetes
Authors: Martin Röhling, Alexander Strom, Gidon Bönhof, Sonja Püttgen, Kálmán Bódis, Karsten Müssig, Julia Szendrödi, Daniel Markgraf, Stefan Lehr, Michael Roden, Dan Ziegler
Journal: Diabetes Care (2016)

OBJECTIVE Both impaired cardiorespiratory fitness (CRF) and heart rate variability (HRV) are predictors of mortality, but their relative roles in recent-onset diabetes are unknown. We determined to which extent CRF and HRV are reduced and interrelated in recent-onset diabetes. RESEARCH DESIGN AND METHODS Participants from the German Diabetes Study with type 1 (n = 163) or type 2 (n = 188) diabetes with known diabetes duration &amp;lt;1 year and two age-matched glucose-tolerant control groups (n = 40 each) underwent spiroergometry and HRV assessment during a hyperinsulinemic-euglycemic clamp. RESULTS Compared with control subjects, patients with type 2 diabetes showed reduced VO2max (median [1st–3rd quartiles] 19.3 [16.5–22.9] vs. 25.6 [20.7–29.9] mL/kg body weight/min; P &amp;lt; 0.05), diminished VCO2max (23.0 [19.1–26.8] vs. 30.9 [24.5–34.4] mL/kg body weight/min; P &amp;lt; 0.05), blunted heart rate recovery after 2 min (−29.0 [−35.0 to −23.0] vs. −36.0 [−42.8 to −28.0] beats/min; P &amp;lt; 0.05), and reduced HRV in four of nine indices, whereas patients with type 1 diabetes had unaltered CRF but reduced HRV in three of nine indices (P &amp;lt; 0.05), indicating diminished vagal and sympathetic HRV modulation. HRV measures correlated with VO2max in patients with type 1 diabetes (r &amp;gt;0.34; P &amp;lt; 0.05) but not in those with type 2 diabetes. CONCLUSIONS CRF is reduced in recently diagnosed type 2 diabetes but preserved in type 1 diabetes, whereas cardiac autonomic function is reduced in both diabetes types but is strongly associated with CRF only in type 1 diabetes. These results support the therapeutic concept of promoting physical fitness in the early course of diabetes.
Fludarabine-Busulfan Conditioning and In Vivo T-Cell Depletion with Reduced Dose of ATG Followed by Allografting Induces Durable Responses in Patients with Advanced Multiple Myeloma with No Grade III-IV aGvHD.
Authors: Nizar J. Bahlis, Douglas A. Stewart, Mary Lynn Savoie, Christopher Brown, Andrew Daly, Ahsan Chaudhry, Jan Storek, James A. Russell
Journal: Blood (2006)
Rviii-Singlechain Pharmacokinetics and Safety in Children Less Than 12 Years of Age
Authors: Claudia Djambas Khayat, Oleksandra Stasyshyn, Genadi Iosava, Jeannie B Ong, Faraizah Abdul Karim, Debra M. Bensen-Kennedy, Katie St. Ledger, Tharin Limsakun, Alex Veldman, Ingrid Pabinger
Journal: Blood (2015)
Feasiblity of Autologous Stem Cell Transplantation (ASCT) in Chronic Lymphocytic Leukemia (CLL) Patients Treated with Sequential Fludarabine and Campath-1H.
Authors: Alessandra Tedeschi, Roberto Cairoli, Marco Montillo, Paola Marenco, Giovanni Grillo, Valentina Rossi, Anna Maria Cafro, Liliana Intropido, Enrica Morra
Journal: Blood (2004)
Prognostic Impact, Phenotypic and Molecular Characterization of Concordant and Discordant Bone Marrow Involvement in Patients with Diffuse Large b-Cell Lymphoma
Authors: Sara Alonso, Miguel Alcoceba, Oscar Blanco, Julio Davila, Juan Carlos Caballero, Luis Garcia, Oscar Ferre, Felix Lopez-Cadenas, Nerea Arratibel, Alvaro Veiga, Monica Baile, Oriana Lopez, Estefania Perez, Maria Dolores Caballero, Marcos González, Consuelo Del Cañizo, Maria Belen Vidriales, Alejandro Martin
Journal: Blood (2015)
Mlecular Monitoring of Acute Myeloid Leukemia Patients Carrying Nucleophosmin (NPM1) Mutations Undergoing An Autologous Peripheral Blood Stem Cell Transplantation
Authors: Valentina Gianfelici, Daniela Diverio, Saveria Capria, Silvia maria Trisolini, Sonia Buffolino, Valentina Derme, Attilio di Lascio, Marilisa Marinelli, Simona Santangelo, Brunangelo Falini, Foà Robert, Meloni Giovanna
Journal: Blood (2008)
Donor Inflammatory Gene Polymorphisms Are Associated with Early Bacterial Infection After Unrelated Allogeneic Haematopoietic Stem Cell Transplantation.
Authors: Haowen Xiao, Xiaoyu Lai, Gongqiang Wu, Yi Luo, Jimin Shi, Yamin Tan, Xiaoyan Han, Wenjun Wu, Wanzhuo Xie, Xiaoli Zhu, Jingsong He, Zhen Cai, Maofang Lin, Xiujin Ye, He Huang
Journal: Blood (2009)
Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles
Authors: Elena Montes-Cobos, Sarah Ring, Henrike J. Fischer, Joachim Heck, Judith Strauß, Markus Schwaninger, Sybille D. Reichardt, Claus Feldmann, Fred Lühder, Holger M. Reichardt
Journal: Journal of Controlled Release (2016)
Genetic Abnormalities in Follicular Lymphoma and Transformed Follicular Lymphoma.
Authors: Alyssa Bouska, Timothy McKeithan, Karen E Deffenbacher, Cynthia Lachel, George W. Wright, Javeed Iqbal, Lynette M. Smith, Zhongfeng Liu, Can Kucuk, Francesco Bertoni, Andrea Rinaldi, Jude Fitzgibbon, Kai Fu, Dennis D Weisenburger, Timothy C. Greiner, Randy D. Gascoyne, Andreas Rosenwald, Elias Campo, Lisa M. Rimsza, Jan Delabie, Elaine S. Jaffe, Louis M. Staudt, Wing-Chung Chan
Journal: Blood (2012)
Unrelated Umbilical Cord Blood Transplantation for Hematological Malignancies Using Fludarabine/BUCY2 Conditioning Regimen
Authors: Zimin Sun, Huilan Liu, Liangquan Geng, Xingbing Wang, Kaiyang Ding, Yun Wu, Chenyang Zhou, Juan Tong, Kaidi Song, Hongjun Liu, Chun Li, Zuyi Wang
Journal: Blood (2011)
Assessment of Quality of Life, Psychological Distress, and Alexithymia in Patients with Cutaneous Lymphoma.
Authors: Francesca Sampogna, Marina Frontani, Giannandrea Baliva, Giuseppe Lombardo, Cristina Di Pietro D Stat, Gabriele Alvetreti, Stefano Tabolli, Damiano Abeni, Giandomenico Russo
Journal: Blood (2006)
Characteristics and Outcomes of Unselected Adolescents and Young Adults Patients with Chronic Myeloid Leukemia in the Tyrosine Kinase Inhibitor Era
Authors: Stéphanie Bernardin, Franck E. Nicolini, Delphine Rea, Mael Haiblig, Martine Gardembas, Gabriel Etienne, P Cony-Makhoul, Martine Escoffre-Barbe, Stephane Giraudier, Agnes Guerci-Bresler, Valérie Coiteux, Marc G Berger, Lydia Roy, Anne Corby, Pierre-Simon Rohrlich, Françoise Huguet, Laurence Legros
Journal: Blood (2014)
Regulation of Endothelin-1 Stimulated-Ca2+-Activated K+ Channel Activity by Protein Disulfide Isomerase Gene Knockdown in Endothelial Cells
Authors: Giselle Brito, Gregory N. Prado, Sonia E. Henriquez, Iren M. Ortiz, Carlos E Vazquez, Shirley D. Valentin, Jose R Romero, Alicia Rivera
Journal: Blood (2011)
A Subpopulation of Blasts with Attenuated p38MAPK Response Is Seen in Virtually All AML Patients and AML Cell Lines and Is Defined By Cells with Augmented Lipid-Associated Anti-Oxidant Defense
Authors: Paul S. Hole, Sara Davies, Chinmay R Munje, Sandra Kreuser, Robert K. Hills, Nader Omidvar, Steven Knapper, Alan K. Burnett, Alex Tonks, Richard L. Darley
Journal: Blood (2014)
Immunomodulation of NK Cells through 4-1BB (CD137) to Improve the Anti-Lymphoma Activity of Rituximab: Antibody-Based Anti-Lymphoma Synergy
Authors: Holbrook E Kohrt, Roch Houot, Matthew J Goldstein, Kipp Weiskopf, Mark Chao, Lieping Chen, Thomas Tedder, Ron Levy
Journal: Blood (2010)
An In Vitro and In Vivo Evidence That Interleukin-8 Is a Pivotal Hypoxia-Regulated Pro-Angiopoietic Factor Secreted by Human Rhabdomyosarcomas (RMS) - Therapeutic Implications.
Authors: Marcin Wysoczynski, Wu Wan, Magda Kucia, Janina Ratajczak, Mariusz Z. Ratajczak
Journal: Blood (2007)
Standardization of WT1 mRNA Quantification for Minimal Residual Disease (MRD) Monitoring in Acute Leukemia Patients: A European LeukemiaNet Concerted Action.
Authors: Enrico Gottardi, Daniela Cilloni, Sarah Daly, S. Green, Niels Pallisgaard, P. Hokland, M. Ostergaard, C. Nyvold, J. Nomdedeu, Fabrizio Pane, Susanne Schnittger, Vincent Van der Velden, Kalid Tobal, Y. Yin Jal, Fabienne Hermitte, Teo De Witte, R. Hehlmann, Giuseppe Saglio, David Grimwade
Journal: Blood (2005)
‘Turban-like’ skull metastasis from pulmonary adenocarcinoma
Authors: Maria Cecilia Mengoli, Giulio Rossi, Marcello Tiseo, Fausto Barbieri, Micol Pifferi, Federica Bertolini, Filippo Lococo
Journal: Thorax (2016)

A 55-year-old woman presented with a progressive psychomotor impairment. She spoke slowly and her motor retardation interfered with activities of daily living. The patient reported that 5 months earlier, she had experienced blunt force trauma of vertex with a progressive swelling of the head. At the time of presentation, a painful, fixed and hard lesion was detected at palpation. Encephalic CT and MRI revealed an osteolytic mass of the skull of 10 cm in maximum diameter, infiltrating the left frontoparietal bones with calcifications (figure 1A, B). The lesion caused a mass effect, without infiltration of the brain parenchyma. A whole-body …
The Genomic Landscape of TEL-AML1+ (ETV6-RUNX1) Acute Lymphoblastic Leukaemia
Authors: Elli Papaemmanuil, Inmaculada Rapado, Anthony M Ford, Keiran Raine, Jonathan Hinton, David Jones, John Marshall, Laura J Mudie, Jan Zuna, Giovanni Cazzaniga, Helena Kempski, Maria S Pombo de Oliveira, Mike R Stratton, P Andrew Futreal, Peter Campbell, Mel Greaves
Journal: Blood (2011)
Detection of a T Cell Clone in the Peripheral Blood at Diagnosis and in the Skin in Complete Clinical Remission after PUVA and Interferon-α Combination Therapy Is Not a Negative Prognostic Factor in Early Mycosis Fungoides.
Authors: Goteri Gaia, Rupoli Serena, Pulini Stefano, Tassetti Angela, Ranaldi Renzo, Scortechini Anna Rita, Capretti Roberta, Filosa Alessandra, Morichetti Doriana, Mulattieri Simonetta, Leoni Pietro
Journal: Blood (2005)
Keratinocyte Growth Factor for Prophylaxis of Oral Mucositis in Children Undergoing Hematopoietic Stem Cell Transplantation.
Authors: Jan Styczynski, Robert Debski, Anna Krenska, Agnieszka Zaucha-Prazmo, Beata Wojcik, Jerzy Kowalczyk, Mariusz Wysocki
Journal: Blood (2006)
Hunt lures doctors into management roles with promise of training at Yale
Authors: Gareth Iacobucci
Journal: BMJ (2016)

The UK government has announced a new fast track programme to encourage doctors into senior management roles in the NHS as part of a package of measures aimed at boosting clinical leadership.

It also plans to double the size of the NHS graduate management training scheme next year from 100 to 200 places (aiming to expand this eventually to 1000 places) and to work with leading British universities to develop a new NHS approved master of business administration (MBA) qualification.

Announcing the plans at the NHS Providers annual conference in Birmingham on 30 November England’s health secretary, Jeremy Hunt, said that the NHS would send 30 doctors and nurses to world leading universities as part of the new fast track development programme for clinicians entering management.

Hunt said that the new scheme would support …
Dysregulated Nucleotide Excision Repair (NER) Is a New Target in Multiple Myeloma
Authors: Raphaël Szalat, Mehmet Kemal Samur, Alice Cleynen, Anne Calkins, Matija Dreze, Yu-Tzu Tai, Stephane Minvielle, Herve Avet-Loiseau, Kenneth C. Anderson, Jean-Paul Fermand, Jean-Bernard Lazaro, Nikhil C. Munshi
Journal: Blood (2015)
A novel combined needle-knife and standard sphincterotome: the dualtome
Authors: Muharrem Keskin
Journal: Endoscopy (2016)

Needle-knife sphincterotomes are usually used during endoscopic retrograde cholangiopancreatography (ERCP) when standard cannulation methods with a cannula alone or even with a standard sphincterotome have failed, but as yet the combination of a standard sphincterotome and a needle-knife sphincterotome has not been used simultaneously. We present a novel sphincterotome, named the "dualtome," that has the features and abilities of both standard and needle-knife sphincterotomes.
Probiotic supplementation in diabetic hemodialysis patients has beneficial metabolic effects
Authors: Alireza Soleimani, Malihe Zarrati Mojarrad, Fereshteh Bahmani, Mohsen Taghizadeh, Mohammad Ramezani, Maryam Tajabadi-Ebrahimi, Parvaneh Jafari, Ahmad Esmaillzadeh, Zatollah Asemi
Journal: Kidney International (2016)
Frequency and Prognosis of JAK2 V617F, Calr, MPL and ASXL1 Mutations in Primary Myelofibrosis
Authors: Marc Sorigue, Marta Cabezón, Olga Garcia, Patricia Velez, Silvia Marce, Concha Boqué, Blanca Xicoy, Cristalina Fernandez, Marisol Xandri, Enric Casanova, David Gallardo, Fuensanta Milla, Josep-Maria Ribera, Evarist Feliu, Lurdes Zamora
Journal: Blood (2014)
Human Telomerase Reverse Transcriptase (hTERT) Deficiency in Myelodysplastic Syndrome (MDS) Demonstrates Mechanistic Linkage to Aplastic Anemia Pathophysiology
Authors: Lili Yang, Adam W Mailloux, Dana E Rollison, Jong Park, Jeffrey S. Painter, Rami S. Komrokji, Jaroslaw P Maciejewski, Ronald Paquette, Thomas P. Loughran, Sheng Wei, Alan F. List, Pearlie K Epling-Burnette
Journal: Blood (2011)
Wireless Capsule Endoscopy (WCE) Is an Important Diagnostic and Management Tool of Gastrointestinal (GI) Acute and Chronic Graft Versus Host Disease (GVHD) after Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) and Identifies Gastroparesis as a Prominent Complication of GI GVHD.
Authors: Prakash Varadarajan, Minoo Battiwalla, Shannon Smiley, Michael Schiff, Theresa Hahn, Philip L. McCarthy
Journal: Blood (2007)
Brief Report: CXCL10 Is a Possible Biomarker for the Development of Psoriatic Arthritis Among Patients With Psoriasis
Authors: Fatima Abji, Remy A. Pollock, Kun Liang, Vinod Chandran, Dafna D. Gladman
Journal: Arthritis & Rheumatology (2016)

Objective Biomarkers that can predict the development of psoriatic arthritis (PsA) in patients with psoriasis would be useful in clinical practice. The aim of this study was to assess whether CXCL10 could be a predictive biomarker of PsA prior to its onset. Methods Psoriasis patients without arthritis were followed up prospectively and assessed annually for development of PsA by a rheumatologist. Patients in whom PsA developed were designated as converters, while those in whom PsA did not develop were termed nonconverters. Baseline serum concentrations of CXCL10 were measured by Luminex assay in 46 converters and 45 nonconverters. Results The level of CXCL10 was significantly higher in converters (median 493 pg/ml [interquartile range (IQR) 356–984]) than in nonconverters (median 371 pg/ml [IQR 263–578]; P = 0.005). In contrast, C‐reactive protein (CRP) levels were not significantly different between converters and nonconverters at baseline. CXCL10 was associated with conversion status after adjustment for age, sex, duration of psoriasis, and duration of follow‐up (odds ratio 1.3, 95% confidence interval 1.1–1.5, P = 0.004). In a subset of converters, the CXCL10 level was significantly higher at baseline (median 927.4 pg/ml [IQR 547.6–1,243]) than after PsA diagnosis (491.5 pg/ml [IQR 323.2–607]; P &lt; 0.0001), while CRP levels were lower at baseline (26.6 μg/ml [IQR 16.37–62.75]) than after PsA diagnosis (36.1 μg/ml [IQR 14.74–101.7]; P = 0.003). CXCL10 gene expression was increased 17.3‐fold in synovial fluid (SF) compared with blood from PsA patients ( P = 0.01) and 44.3‐fold in the SF of PsA patients compared with the SF of patients with gout ( P = 0.001). Conclusion CXCL10 may be involved in PsA pathogenesis and is a candidate predictive biomarker for PsA in patients with psoriasis.
PI3Kdelta Inhibitor, CAL-101, De-Adheres Primary Pre-B ALL from VCAM-1 and Induces Apoptosis in Primary Pre-B ALL
Authors: Sajad Khazal, Enzi Jiang, Stephanie Shishido, Osanna Kosoyan, Kim Hye-Na, Alexa Velasquez, Yao-Te Hsieh, Hisham Abdel-Azim, Ann M Mohrbacher, Akil Merchant, Alan S. Wayne, Nora Heisterkamp, Yong-Mi Kim
Journal: Blood (2014)
A Novel Chemical Approach to Expand Platelets Using Immortalized Megakaryocyte Progenitor Cells Derived from Human Induced Pluripotent Stem Cells
Authors: Ayako Otani, Tomo Koike, Natsuki Abe, Takanori Nakamura, Taito Nishino, Hiromitsu Nakauchi, Koji Eto
Journal: Blood (2014)
Anemia during Pegylated Interferon-Ribavirin Therapy Results from Both Increase Suppression of Erythroid Differentiation and Hemolysis
Authors: Luisa Ronzoni, Alessio Aghemo, Maria Grazia Rumi, Alessandra Colancecco, Sara Monico, Paolo Grillo, Massimo Colombo, Maria Domenica Cappellini
Journal: Blood (2008)
Multidisciplinary Approach to Novel Therapies in Cardio-Oncology Research (MANTICORE 101–Breast): A Randomized Trial for the Prevention of Trastuzumab-Associated Cardiotoxicity
Authors: Edith Pituskin, John R. Mackey, Sheri Koshman, Davinder Jassal, Marshall Pitz, Mark J. Haykowsky, Joseph J. Pagano, Kelvin Chow, Richard B. Thompson, Larissa J. Vos, Sunita Ghosh, Gavin Y. Oudit, Justin A. Ezekowitz, D. Ian Paterson
Journal: Journal of Clinical Oncology (2017)

Purpose The primary toxicity of trastuzumab therapy for human epidermal growth factor receptor 2-overexpressing (HER2-positive) breast cancer is dose-independent cardiac dysfunction. Angiotensin-converting enzyme inhibitors and β-blockers are recommended first-line agents for heart failure. We hypothesized that angiotensin-converting enzyme inhibitors and β-blockers could prevent trastuzumab-related cardiotoxicity. Patients and Methods In this double-blinded, placebo-controlled trial, patients with HER2-positive early breast cancer were randomly assigned to receive treatment with perindopril, bisoprolol, or placebo (1:1:1) for the duration of trastuzumab adjuvant therapy. Patients underwent cardiac magnetic resonance imaging at baseline and post-cycle 17 for the determination of left ventricular volumes and left ventricular ejection fraction (LVEF). Cardiotoxicity was evaluated as the change in indexed left ventricular end diastolic volume and LVEF. Results Thirty-three patients received perindopril, 31 received bisoprolol, and 30 received placebo. Baseline demographic, cancer, and cardiovascular profiles were similar between groups. Study drugs were well tolerated with no serious adverse events. After 17 cycles of trastuzumab, indexed left ventricular end diastolic volume increased in patients treated with perindopril (+7 ± 14 mL/m2), bisoprolol (+8 mL ± 9 mL/m2), and placebo (+4 ± 11 mL/m2; P = .36). In secondary analyses, trastuzumab-mediated decline in LVEF was attenuated in bisoprolol-treated patients (-1 ± 5%) relative to the perindopril (-3 ± 4%) and placebo (-5 ± 5%) groups ( P = .001). Perindopril and bisoprolol use were independent predictors of maintained LVEF on multivariable analysis. Conclusion Perindopril and bisoprolol were well tolerated in patients with HER2-positive early breast cancer who received trastuzumab and protected against cancer therapy-related declines in LVEF; however, trastuzumab-mediated left ventricular remodeling-the primary outcome-was not prevented by these pharmacotherapies.
Once-Daily Treatment with the Oral Iron Chelator ICL670 (Exjade®): Results of a Phase II Study in Pediatric Patients with β-Thalassemia Major.
Authors: Antonio Piga, Renzo Galanello, Maria Loreta Foschini, Antonella Zappu, Elena Bordone, Filomena Longo, Gian-Luca Forni, Antonella Lavagetto, Yves Bertrand, Henry Maseruka, Nicola Latham, Daniele Alberti
Journal: Blood (2004)