tbuckley/cabot-search huggingface dataset:
FRI0582-HPR Extracorporeal shock wave therapy versus low intensity laser therapy in the treatment of heel pain
Authors: E. CINAR, F. UYGUR
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Plantar heel pain in adulthood is a common, disabling and chronic foot problem. Most cases have a biomechanical etiology however various systemic arthritis also causes heel pain. Plantar fasciitis which is caused by secondary degenerative changes in the plantar fascia, is the most common cause of plantar heel pain. Despite the common use of low intensity laser therapy (LILT) and extracorporeal shock wave therapy(ESWT)inmusculoskeletal problems such as plantar fasciitis there is no randomized controlled study comparing the efficacy of these treatment modalities. <h3>Objectives</h3> To compare the efficacy of LILT and ESWT in the treatment of plantar fasciitis. <h3>Methods</h3> Fifty-five patients with plantar fasciitis were randomly allocated into the laser group(29 patients) who received Gallium-Aluminum-Arsenide laser therapy with 850nm wavelength for 10 sessions 3 times a week and ESWTgroup (26 patients) who received 2000 shock waves with 0.02 mJ/mm2 for three sessions once a week. Foot Function Index,12 minutes walk test and VAS were used for evaluation. <h3>Results</h3> In the laser group pre-post treatment values showed a significant difference in favor of post treatment values in all measured parameters whereas in the ESWT group no difference was found in gait velocity or pain. Intergroup comparisons showed that LILT was more effective in reducing pain, increasing the speed of walking and in increasing perceived quality of life. <h3>Conclusions</h3> The results of this study suggest that LILT is more effective than ESWT in the treatment of heel pain. <h3>References</h3> Buchbinder R. Clinical practice. Plantar fasciitis. N Engl J Med 2004; 350: 2159-2166. Yalcin E. Akca Keskin A. Secuk B. Kurtaran A. Akyuz M. Effects of extracorporal shock wave therapy on symptomatic heel spurs: a correlation between clinical outcome and radiologic changes. Rhematol Int. 2012;32: 343-347. Johal KS, Milner SA. Plantar fasciit and the calcaneal spur: Fact or function? Foot Ankle surg. 2012; 18(1):39-41. <h3>Disclosure of Interest</h3> None Declared
SAT0025 Pregnancy Outcomes in A Cohort of Women with Sle. Long Term 20 Years Observation
Authors: D. Tegzova, K. Andelova, I. Kucerova, J. Madar, J. Stejskal, V. Vlasakova, E. Figurova, J. Kovarik, C. Dostal
Journal: Annals of the Rheumatic Diseases (2014)

International private equity firms took center stage in South Korea in the late 1990s, riding to the rescue of troubled companies laid low in the Asian economic meltdown. But in the aftermath of recent high-profile criminal investigations surrounding the Lone Star acquisition of Korea Exchange Bank, private equity investors have had to write a new script. With Korea9s economy strong, western private equity firms are acquiring underperforming business units from Korea9s leading chaebols and helping them become more competitive, providing capital and management skills to help Korean entrepreneurs fuel their growth, and joining forces with strategic partners who can complement their deal-making mastery with local business know-how. <b>TOPICS:</b>Private equity, developed, legal/regulatory/public policy
Fluorescent Treponemal Antibody-Absorption Test Reactions in Lupus Erythematosus
Authors: Stephen J. Kraus, John R. Haserick, Marjorie A. Lantz
Journal: New England Journal of Medicine (1970)

Several serologic tests for syphilis (Venereal Disease Research Laboratory [VDRL] slide test, fluorescent treponemal antibody-absorption [FTA-ABS] test, and Treponema pallidum immobilization [TPI] test) were performed on serums from 150 patients with lupus erythematosus. VDRL tests were reactive in 24 patients, and the TPI test in one. Twenty-three patients showed some degree of fluorescence in the FTA-ABS test; of these, four were reactive (one of these had the reactive TPI test), and eight were borderline. In the other 11, an atypical "beading" fluorescence pattern was noted, in contrast to the homogeneous pattern of fluorescence usually seen. VDRL reactivity and FTA-ABS fluorescence in the whole group were independent variables. No clinical or historical evidence of syphilis could be found in any of the 23 patients. A group of 75 "normal" controls showed no reactivity in the VDRL, FTA-ABS or TPI tests.
Stat Bite Incidence of Testicular Cancer in U.S. Men
Authors: Eric J. Feuer
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite Incidence of Testicular Cancer in U.S. Men Get access Eric J. Feuer Eric J. Feuer Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 6, 15 March 1995, Page 405, https://doi.org/10.1093/jnci/87.6.405 Published: 15 March 1995
Clinical Investigation of Smallpox in 1767
Authors: Arthur W Boylston
Journal: New England Journal of Medicine (2002)

In 1767, William Watson was the physician for the Hospital for the Maintenance and Education of Exposed and Deserted Children, universally known as the Foundling Hospital, which was established in 1739 to provide a home for some of London's abandoned children. His practice was devoted entirely to the care and treatment of children accepted into this charitable establishment. At the time, the leading cause of death among children in London was smallpox. The infection was endemic and killed about one in four children born in the city. When the Foundling Hospital was opened, the board of governors recognized that because . . .
β-blockers in pulmonary arterial hypertension: generation might matter
Authors: Simon Malenfant, Frédéric Perros
Journal: European Respiratory Journal (2016)

We read with great interest the article from Bandyopadhyay et al . [1] regarding the outcomes of β-blockers use in pulmonary arterial hypertension (PAH). This study adds another piece in the very controversial debate opposing pro- and anti-supporters of β-blockers use in PAH. In this study, patients had idiopathic PAH (IPAH) or connective tissue disease-associated PAH. PAH patients receiving β-blockers had a similar survival and time to clinical worsening events compared with patients not receiving them. Functional outcomes were similar, although β-blocker use was associated with a tendency towards shorter walking distance. Malenfant and Perros discuss the potential usefulness of third generation β-blockers in pulmonary hypertension <http://ow.ly/VKMFn>
Population-Based Breast Cancer Screening With Risk-Based and Universal Mammography Screening Compared With Clinical Breast Examination
Authors: Amy Ming-Fang Yen, Huei-Shian Tsau, Jean Ching-Yuan Fann, Sam Li-Sheng Chen, Sherry Yueh-Hsia Chiu, Yi-Chia Lee, Shin-Liang Pan, Han-Mo Chiu, Wen-Horng Kuo, King-Jen Chang, Yi-Ying Wu, Shu-Lin Chuang, Chen-Yang Hsu, Dun-Cheng Chang, Shing-Lang Koong, Chien-Yuan Wu, Shu-Lih Chia, Mei-Ju Chen, Hsiu-Hsi Chen, Shu-Ti Chiou
Journal: JAMA Oncology (2016)

<h3>Importance</h3> Different screening strategies for breast cancer are available but have not been researched in quantitative detail. <h3>Objective</h3> To assess the benefits and the harms of risk-based and universal mammography screening in comparison with annual clinical breast examination (CBE). <h3>Design</h3> Population-based cohort study comparing incidences of stage II+ disease and death from breast cancer across 3 breast cancer screening strategies, with adjustment for a propensity score for participation based on risk factors for breast cancer and comparing the 3 strategies for overdetection between January 1999 and December 2009. Asymptomatic women attending outreach screening in the community or undergoing mammography in hospitals were enrolled in the 3 screening programs. <h3>Interventions</h3> Risk-based biennial mammography, universal biennial mammography, and annual CBE. <h3>Main Outcomes and Measures</h3> Detection rates, stage II+ disease incidence, mortality from breast cancer, and overdiagnosis were compared using a time-dependent Cox proportional hazards regression model. <h3>Results</h3> A total of 1 429 890 asymptomatic women attending outreach screening in the community or undergoing mammography in hospitals were enrolled in the 3 screening programs. Detection rates (prevalent screen and subsequent screens per 1000) were the highest for universal biennial mammography (4.86 and 2.98, respectively), followed by risk-based mammography (2.80 and 2.77, respectively), and lowest for annual CBE (0.97 and 0.70, respectively). Universal biennial mammography screening, compared with annual CBE, was associated with a 41% mortality reduction (risk ratio, 0.59; 95% CI, 0.48-0.73) and a 30% reduction of stage II+ breast cancer (RR, 0.70; 95% CI, 0.66-0.74). Risk-based mammography screening was associated with an 8% reduction of stage II+ breast cancer (RR, 0.92; 95% CI, 0.86-0.99) but was not associated with a statistically significant mortality reduction (risk ratio [RR], 0.86; 95% CI, 0.73-1.02). Estimates of overdiagnosis were no different from CBE for risk-based screening and 13% higher than CBE for universal mammography. <h3>Conclusions and Relevance</h3> Compared with population-based screening for breast cancer with annual CBE, universal biennial mammography resulted in a substantial reduction in breast cancer deaths, whereas risk-based biennial mammography resulted in only a modest benefit. Compared with annual CBE, risk-based and universal mammography screening did not result in significant overdiagnosis of breast cancer.
EFFECT OF UPSTREAM AND DOWNSTREAM BIFURCATION PROXIMITY ON CORONARY PLAQUE CHANGES AFTER 1 YEAR USING COMPUTER AIDED INTRAVASCULAR ULTRASOUND ANALYSIS
Authors: Zhi Chen, Andreas Wahle, Hana Skalicka, Ales Kral, John Lopez, Tomas Kovarnik, Milan Sonka
Journal: Journal of the American College of Cardiology (2016)
TWO-YEAR CLINICAL OUTCOME OF THE NOBORI BIOLIMUS-ELUTING STENT VERSUS XIENCE/PROMUS EVEROLIMUS-ELUTING STENT IN REAL-WORLD CLINICAL PRACTICE
Authors: Shoichi Kuramitsu, Takashi Hiromasa, Yohei Kobayashi, Hiroyuki Jinnouchi, Takashi Morinaga, Toru Mazaki, Hisaki Masuda, Takenori Domei, Makoto Hyodo, Shinichi Shirai, Kenji Ando
Journal: Journal of the American College of Cardiology (2015)
P1144 DETERMINING THE COMPARATIVE EFFECTIVENESS OF EMERGING TREATMENT REGIMENS FOR HEPATITIS C VIRUS (HCV) INFECTION FROM SINGLE ARM PHASE III TRIALS
Authors: M. Quintana, K. Broglio, E.S. Daar, Y. Yuan, A. Kalsekar, M.A. Detry, R.J. Lewis, T. Le, S.M. Berry
Journal: Journal of Hepatology (2014)
RENAL TUBULAR RESISTANCE, RATHER THAN DIURETIC DELIVERY, IS THE PRIMARY DRIVER FOR DIURETIC RESISTANCE IN ACUTE HEART FAILURE PATIENTS
Authors: Jozine M. ter Maaten, Veena Rao, Jennifer Simon, Mahlet Assefa, Sam Broughton, Karen Modesto, Kevin Damman, Adriaan Voors, Wai Hong Tang, Jeffrey Testani
Journal: Journal of the American College of Cardiology (2016)
Statistical methods for hazards and health.
Authors: Y M Bishop
Journal: Environmental Health Perspectives (1977)

The objective of this article is to document the need for further development of statistical methodology, training of more statisticians and improved communication between statisticians and the many other disciplines engaged in environmental research. Discussion of adequacy of the current statistical methodology requires the use of examples, which will hopefully not be offensive to the authors. Reference is made to recent developments and areas of unsolved problems delineated in three broad areas: enumeration data and adjusted rates; time series; and multiple regression. A brief outline of the ideas behind current methods of analyzing discrete data is followed by a demonstration of their utility using an example of the effects of exposure, sex, and education on bronchitis rates. Examples are listed of the ubiquity of the time component when relating pollution effects to each other and to health effects. An artificial example is used to emphasize the effects of time-dependent autocorrelations, trends, and cycles. References are given to a variety of new developments in time-dependent autocorrelations, trends, and cycles. References are given to a variety of new developments in time-series analysis. Discussion of the pitfalls in multiple regression analysis, and possible alternative approaches is largely based on two recent reviews and includes references to recent developments of robust techniques.
Anti-Smoking Forces Retaliat Against Overseas Tobacco Marketing
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Anti-Smoking Forces Retaliat Against Overseas Tobacco Marketing Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 10, 15 May 1991, Pages 677–679, https://doi.org/10.1093/jnci/83.10.677 Published: 15 May 1991
Bacillary Angiomatosis or Kaposi's Sarcoma?
Authors: J W Tappero, J E Koehler
Journal: New England Journal of Medicine (1997)

Figure 1. Bacillary angiomatosis and Kaposi's sarcoma can be especially difficult to differentiate clinically. In each pair of figures, one shows a bacillary angiomatosis lesion (Panels A and B) and one shows a clinically indistinguishable Kaposi's sarcoma lesion (Panels C and D). There are many causes of moist, erosive cutaneous vascular lesions in immunocompromised patients. A tissue biopsy is required for diagnosis. Other bacterial and fungal infections, as well as pyogenic granuloma, may also have similar clinical appearances. On routine staining with hematoxylin and eosin, bacillary angiomatosis lesions show acute neutrophilic inflammation and capillary proliferation. Kaposi's sarcoma lesions show slit-like . . .
Abstract LB-50: Ionizing radiation can enhance TGFß induced EMT: Investigation of signatures of cross-talk with the ATM pathway
Authors: Minli Wang, Megumi Hada, Janice Pluth, Jennifer Anderson, Peter O'Neill, Francis Cucinotta
Journal: Cancer Research (2011)

Abstract Epithelial-mesenchymal transition (EMT), a process whereby epithelial cells undergo transition to a mesenchymal phenotype, has long been known to play a role in cellular differentiation during development and tumor invasion. EMT can be viewed as an extreme form of cell plasticity characterized by loss of epithelial markers, cytoskeletal reorganization, and transition to a spindle-shaped morphology concurrent with acquisition of mesenchymal markers. Whereas EMT can be induced by a wide array of stimuli and cytokines, TGFβ is considered to be a key player of the process. Ionizing radiation (IR), both a carcinogen and a therapeutic agent, induces TGFβ activation in vivo, and also sensitizes human epithelial cells to undergo TGFβ-mediated EMT. In order to understand the likelihood of EMT following space radiation exposures to astronauts, we investigated possible interactions between the TGFβ and ATM pathway following radiation using hTERT immortalized human esophageal epithelial cells (EPC-hTERT), and mink lung epithelial cells (Mv1Lu). The identification of EMT can be shown in changes to morphology, related gene over expression or down regulation, which can be detected by RT-PCR, immunostaining and western blotting. Our study shows EMT can be induced by TGFβ alone, and a combination of heavy ion or proton radiation and TGFβ treatment in non-transformed Mv1Lu and EPC-hTERT cells can enhance the induction of EMT, with a dose as low as 0.1Gy. Pretreatment with TGFβRI inhibitor (SD208) can efficiently attenuate the Smad signaling pathway as detected by the phosphorylation of Smad2, as well as EMT. Serum deprival can also induce EMT-like phenotype in epithelial cells, which can be minimized by the TGFβRI inhibitor. In order to detail the role of the DNA damage response in EMT, we are studying inhibition of ATM or p53 in relation to TGFβ induced EMT. Results for cells irradiated in the presence of TGFβ, and the resulting function of ATM or p53 in the TGFβ mediated EMT process will be reported. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-50. doi:10.1158/1538-7445.AM2011-LB-50
Overexpression of G Protein-Activated Inward Rectifier Potassium Channel 1 (GIRK1) is Associated with Lymph Node Metastasis and Poor Prognosis in Breast Cancer
Authors: S. Kammerer, A. Sokolowski, H. Hackl, S. Jahn, M. Asslaber, F. Symmans, F. Peintinger, P. Regitnig, W. Schreibmayer, T. Bauernhofer
Journal: Annals of Oncology (2014)
Cytochrome P450 (CYP) 2A6 Genetic Variation Predicts Letrozole Plasma Concentrations in Postmenopausal Women with Breast Cancer.
Authors: Z. Desta, R. Tyndale, E. Hoffmann, Y. Kreutz, A. Nguyen, D. Flockhart
Journal: Cancer Research (2009)

Abstract Background: The potent aromatase inhibitor (AI) letrozole is effective in the treatment of postmenopausal women with steroid-hormone-receptor–positive breast cancer (metastatic, neoadjuvant and adjuvant). The beneficial and adverse effects of letrozole vary widely among patients, and differences in pharmacokinetics may contribute to this variability. Letrozole is primarily cleared by hepatic metabolism. Since CYP2A6 has been implicated in letrozole metabolism in vitro, we tested the influence CYP2A6 genetic variants on plasma concentrations of letrozole in breast cancer patients. Methods: Postmenopausal women with early stage hormone receptor-positive breast cancer were recruited into an ongoing multicenter randomized clinical trial to study the pharmacogenomics of two AIs, exemestane (25 mg/day) and letrozole (2.5 mg/day) given orally. Total accrual to the trial is anticipated to be 250 in each arm. Three months plasma letrozole concentrations were measured by HPLC from 146 patients who were randomized to the letrozole arm and multiple CYP2A6 variants were genotyped from genomic DNA. Results: Plasma concentrations of letrozole showed wide variability among patients (16.6 ng/ml to 141.2 ng/ml; 8.5-fold difference). Genotypes were grouped based in to normal (*1/*1), intermediate (*1/*9 and *1/*12, n=23) and slow (*9/*12, *1/*2, *2/*9, *1/*35, *1/*4E; n=12) metabolizers based on genotyped predicted phenotype. A statistically significant difference in letrozole concentrations was observed among the patients with the different genotype groups (p&amp;lt;0.0001; one-way ANOVA), with strong gene-dose effect relationship (r2=0.28; p&amp;lt;0.0001). Letrozole plasma concentrations were significantly higher in patients with the slow or intermediate genotypes than those with normal genotype (p &amp;lt; 0.0001; Dunn's post-test for multiple comparison correction).Conclusions: Polymorphisms in the CYP2A6 gene account for ∼28% of variability in letrozole concentrations in breast cancer patients. Prior genotyping for CYP2A6 variants may help to identify patients who benefit from letrozole and who experience adverse effects from the drug. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5160.
SAT0327 Study of the Prevalence and Predicting Factors of Osteoporosis in Patients with Systemic Sclerosis: A Case-Control Study
Authors: M. Marot, A. Valéry, E. Estève, G. Bens, A. Müller, S. Rist, E. Lespessailles
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> In chronic inflammatory rheumatism and also in connective tissue diseases including rheumatoid arthritis and systemic erythematosus lupus, there is an increased risk of osteoporosis and osteoporotic fracture. In contrast, bone involvement in systemic sclerosis (SSc) is still debated. There is currently no recommendation for systematic research of osteoporosis in SSc. <h3>Objectives</h3> The aim of our study was to investigate the existence of an increased prevalence of osteoporosis in patients with systemic sclerosis (SSc), to describe the qualitative alterations of bone tissue with the High-resolution peripheral quantitative computed tomography (HR-pQCT), comparing these patients to a group of healthy women, and to identify specific factors influencing SSc bone disease. <h3>Methods</h3> We conducted a cross-sectional study of consecutively including patients with SSc and healthy women, matched on age, body mass index (BMI) and duration of menopause. Risk factors for osteoporosis was collected from all subjects. Bone mineral density (BMD) was measured at the lumbar spine, femoral neck and total hip by dual energy X-ray absorptiometry (DXA). The volumetric bone mineral density (vBMD) and bone microarchitecture parameters were measured by the HR-pQCT at the tibia and radius. <h3>Results</h3> Thirty-three patients and 33 controls were included. The BMI of the patients was significantly lower (p&lt;0.029). The prevalence of osteoporosis in postmenopausal patients was significantly higher than controls (42.8% versus 10.7%, p&lt;0.05). After adjustment for BMI, BMD at the total hip was significantly lower in patients compared to controls (p&lt;0.015). The HR-pQCT analysis showed a significant alteration of the trabecular compartment in patients, in particular a decrease in trabecular vBMD on both sites (p&lt;0.01). In multivariate analysis, a low lean body mass, the presence of anti-centromere antibodies and older age were identified as independent factors for decreased BMD at the lumbar spine (R<sup>2</sup>=0.43;p=0.0009), decreased BMD at the femoral neck (R<sup>2</sup>=0.61;p&lt;0.0001) and decreased BMD at the total hip (R<sup>2</sup>=0.73;p&lt;0.0001). Digital ulcers were also identified as an independent factor for microarchitecture alteration. <h3>Conclusions</h3> An increased prevalence of osteoporosis was found in patients with SSc. The HR-pQCT showed impaired trabecular bone compartment in patients. Low lean body mass, high age, digital ulcers and anti-centromere antibodies were identified as independent risk factors for bone damage. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4362
ANGIOTENSIN-CONVERTING ENZYME INHIBITORS AND ANGIOTENSIN RECEPTOR BLOCKERS IN PATIENTS WITH CARDIOVASCULAR RISK FACTORS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Vu Linh Hoang, Daniel Addison, Don Pham, Mahboob Alam, Yochai Birnbaum
Journal: Journal of the American College of Cardiology (2015)