tbuckley/cabot-search huggingface dataset:
PTH-106 Survival outcomes following hepatectomy for stage iv colorectal liver metastases: a comparison of liver- versus colon-first approach
Authors: V Yip
Journal: Gut (2015)

<h3>Introduction</h3> Liver-first approach compared to colon-first staged approach has been advocated for stage IV colorectal liver metastases (CRLM), but there is limited survival data to compare between these strategies. Our aim was to compare long term survival outcomes for liver- versus colon-first approach for stage IV CRLM. <h3>Method</h3> Between 2008 and 2013, patients with completed liver and colon resections for stage IV CRLM were included in this study. Patients with extrahepatic disease, synchronous resections and emergency colectomies were excluded. Patients in liver- (A) and colon- (B) first were stratified and compared using the Fong’s Clinical Risk Score (CRS). <h3>Results</h3> N=172 patients presented with stage IV colorectal cancer during the study period. N=25 had extrahepatic metastases, and were excluded. A further n = 88 patients, who underwent liver or colon resection were excluded as a result of disease progression (n = 11 liver n = 77 colon). N=59 (40%) had completed both liver and colonic resections, and comprised the study group (Group A: N=31; Group B: N=29). All patients had undergone neoadjuvant chemotherapy prior to resection. There was no difference in terms of age (p = 0.213), gender (p = 0.424), number (p = 0.839) and size (p = 0.725) of liver lesions in both groups. Fong’s CRS (1–5) was not significantly different for both treatment groups (p = 0.450). There was no difference in the overall survival (OS) (p = 0.846) and disease-free survival (DFS) (p = 0.675) between Group A and Group B. One-, 3- and 5-year OS for Group A versus Group B were 94% vs. 97%, 75% vs. 76% and 46% vs. 54%; and the DFS was 76% vs. 78%, 41% vs. 28% and 41% vs. 22% respectively. <h3>Conclusion</h3> The overall survival for liver-first approach is comparable to classic staged approach for stage IV colorectal cancer. Although not statistically significant, liver-first approach appears to provide a better disease-free survival at 3- and 5-years. <h3>Disclosure of interest</h3> None Declared.
Noninvasive Dynamic Imaging of Tumor Early Response to Nanoparticle-mediated Photothermal Therapy
Authors: Fan Zhang, Jianbo Cao, Xiao Chen, Kai Yang, Lei Zhu, Guifeng Fu, Xinglu Huang, Xiaoyuan Chen
Journal: Theranostics (2015)

In spite of rapidly increasing interest in the use of nanoparticle-mediated photothermal therapy (PTT) for treatment of different types of tumors, very little is known on early treatment-related changes in tumor response.Using graphene oxide (GO) as a model nanoparticle (NP), in this study, we tracked the changes in tumors after GO NP-mediated PTT by magnetic resonance imaging (MRI) and quantitatively identified MRI multiple parameters to assess the dynamic changes of MRI signal in tumor at different heating levels and duration.We found a time-and temperature-dependent dynamic change of the MRI signal intensity in intratumor microenvironment prior to any morphological change of tumor, mainly due to quick and effective eradication of tumor blood vessels.Based on the distribution of GO particles, we also demonstrated that NP-medited PTT caused heterogeneous thermal injury of tumor.Overall, these new findings provide not only a clinical-related method for non-invasive early tracking, identifying, and monitoring treatment response of NP-mediated PTT but also show a new vision for better understanding mechanisms of NP-mediated PTT.
X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene
Authors: Chantal Lagresle-Peyrou, Sonia Luce, Farid Ouchani, Tayebeh Shabi Soheili, Hanem Sadek, Myriam Chouteau, Amandine Durand, Isabelle Pic, Jacek Majewski, Chantal Brouzes, Nathalie Lambert, Armelle Bohineust, Els Verhoeyen, François-Loïc Cosset, Aude Magerus-Chatinet, Frédéric Rieux-Laucat, Virginie Gandemer, Delphine Monnier, Catherine Heijmans, Marielle van Gijn, Virgil A. Dalm, Nizar Mahlaoui, Jean-Louis Stephan, Capucine Picard, Anne Durandy, Sven Kracker, Claire Hivroz, Nada Jabado, Geneviève de Saint Basile, Alain Fischer, Marina Cavazzana, Isabelle André-Schmutz
Journal: Journal of Allergy and Clinical Immunology (2016)
PO01DISPARATE RADIATION RESPONSE OF SLOW PROLIFERATING CANCER STEM CELLS
Authors: F.A. Siebzehnrubl, N. Nabilsi, N. Pasternack, M. Rohaus, B.G. Griffith, K. Dajac, J. Patel, A. Harding, M.P. Kladde, D.A. Steindler, B.A. Reynolds, L.P. Deleyrolle
Journal: Neuro-Oncology (2015)

INTRODUCTION: Glioblastoma (GBM) remains the most frequent and lethal of all adult brain tumours.Recurrence after therapy particularly contributes to poor outcome.Cancer stem cells (CSC) have been identified as a cellular source that is more resistant to anti-cancer therapy and capable of initiating new tumour growth.We previously found that isolating slow proliferating cells from GBM enriches for a population with CSC properties.METHOD: Using primary patient-derived GBM cells, label-retention assays and flow cytometry, we studied invasion, therapy resistance and stemness of slow-dividing GBM cells in vitro and in vivo.RESULTS: Here, we show that these slowdividing CSC are more invasive and more resistant to chemotherapy than the rest of the tumour population.Surprisingly, slow-proliferating cells are initially more sensitive to radiation damage.We find a significant overlap between the slow-dividing compartment and expression of the transcription factor ZEB1, which we have recently identified as a master regulator of stemness and chemoresistance in GBM.Consequently, ZEB1+ cells also exhibit greater radiosensitivity.Slow proliferating, ZEB1+ cells accumulate genomic aberrations correlated with retention in the G2/M phase of the cell cycle, rendering these cells more sensitive to radiation damage.However, from this specific subpopulation, a fraction of cells that survive irradiation rebound with a proliferative burst that may contribute to recurrence of more aggressive tumours.CONCLUSION: This disparate effect of radiation on CSC points to a previously underappreciated heterogeneity within the CSC compartment and may open up new avenues of studying and targeting specific CSC sub-populations.
Overrepresentation of influenza A(H1N1)pdm09 virus among severe influenza cases in the 2011/12 season in four European countries
Authors: J Beauté, E Broberg, F Plata, I Bonmarin, J O’Donnell, C Delgado, N Boddington, R Snacken
Journal: Eurosurveillance (2012)

In France, Ireland, Spain and the United Kingdom, the influenza season 2011/12 started in the final weeks of 2011 and has been dominated by influenza A(H3) viruses with minimal circulation of influenza A(H1N1) pdm09 and B viruses. A relatively greater proportion, however, of influenza A(H1N1)pdm09 viruses were reported in hospitalised laboratory-confirmed influenza cases in four countries. Compared to the season 2010/11, the proportion of subtype A(H3) among hospitalised cases has increased, associated with a larger proportion of cases in the youngest and oldest age groups.
Nucleolin Promotes Heat Shock–Associated Translation of VEGF-D to Promote Tumor Lymphangiogenesis
Authors: Florent Morfoisse, Florence Tatin, Fransky Hantelys, Aurelien Adoue, Anne-Catherine Helfer, Stephanie Cassant-Sourdy, Françoise Pujol, Anne Gomez-Brouchet, Laetitia Ligat, Frederic Lopez, Stephane Pyronnet, Jose Courty, Julie Guillermet-Guibert, Stefano Marzi, Robert J. Schneider, Anne-Catherine Prats, Barbara H. Garmy-Susini
Journal: Cancer Research (2016)

The vascular endothelial growth factor VEGF-D promotes metastasis by inducing lymphangiogenesis and dilatation of the lymphatic vasculature, facilitating tumor cell extravasion. Here we report a novel level of control for VEGF-D expression at the level of protein translation. In human tumor cells, VEGF-D colocalized with eIF4GI and 4E-BP1, which can program increased initiation at IRES motifs on mRNA by the translational initiation complex. In murine tumors, the steady-state level of VEGF-D protein was increased despite the overexpression and dephosphorylation of 4E-BP1, which downregulates protein synthesis, suggesting the presence of an internal ribosome entry site (IRES) in the 5' UTR of VEGF-D mRNA. We found that nucleolin, a nucleolar protein involved in ribosomal maturation, bound directly to the 5'UTR of VEGF-D mRNA, thereby improving its translation following heat shock stress via IRES activation. Nucleolin blockade by RNAi-mediated silencing or pharmacologic inhibition reduced VEGF-D translation along with a subsequent constriction of lymphatic vessels in tumors. Our results identify nucleolin as a key regulator of VEGF-D expression, deepening understanding of lymphangiogenesis control during tumor formation. Cancer Res; 76(15); 4394-405. ©2016 AACR.
Human Plague — United States, 2015
Authors: Natalie Kwit, Christina Nelson, Kiersten Kugeler, Jeannine Petersen, Lydia Plante, Hayley Yaglom, Vicki Kramer, Benjamin Schwartz, Jennifer House, Leah Colton, Amanda Feldpausch, Cherie Drenzek, Joan Baumbach, Mark DiMenna, Emily Fisher, Emilio Debess, Danielle Buttke, Matthew Weinburke, Christopher Percy, Martin Schriefer, Ken Gage, Paul Mead
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Since April 1, 2015, a total of 11 cases of human plague have been reported in residents of six states: Arizona (two), California (one), Colorado (four), Georgia (one), New Mexico (two), and Oregon (one). The two cases in Georgia and California residents have been linked to exposures at or near Yosemite National Park in the southern Sierra Nevada Mountains of California. Nine of the 11 patients were male; median age was 52 years (range = 14-79 years). Three patients aged 16, 52, and 79 years died.
Limitations and values of evaluation techniques in psychiatric education
Authors: S M Small
Journal: American Journal of Psychiatry (1975)

The author presents a summary of the major evaluation techniques now available and discusses the values and limitations of each. He concludes that only by the use of many evaluation instruments during the resident's period of training can some estimate of clinical competence be approached. Even with this multiplicity of testing instruments, the validity of predictions of a psychiatrist's performance can be determined only in terms of probabilities.
Atlas and Epitome of Operative Surgery.
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Auditory hallucinations in combat-related chronic posttraumatic stress disorder
Authors: K T Mueser, R W Butler
Journal: American Journal of Psychiatry (1987)

Intrusive images have been reported to occur in a broad range of people with posttraumatic stress disorder, but the frequency of intrusive auditory perceptions has rarely been addressed. This study compared five posttraumatic stress disorder veterans experiencing auditory hallucinations with 31 nonhallucinating veterans on demographic, military, postmilitary, and symptom variables. Veterans who reported auditory hallucinations had higher combat exposure and more intense posttraumatic stress disorder symptoms than the other veterans. These veterans also tended to be more refractory to treatment than veterans with no hallucinations. Clinical vignettes of the veterans with auditory hallucinations are given, and the implications of the results for a subgroup of chronic posttraumatic stress disorder veterans are discussed.
Germline Events In GFI1 In Myelodysplastic Syndrome
Authors: Swapna Thota, Sarah McMahon, Hideki Makishima, Bartlomiej P Przychodzen, Kathryn M Guinta, Brittney Dienes, Naoko Hosono, Mikkael A. Sekeres, Jaroslaw P. Maciejewski
Journal: Blood (2013)
Differences in incomes of physicians in the United States by race and sex: observational study
Authors: Dan P Ly, Seth A Seabury, Anupam B Jena
Journal: BMJ (2016)

<b>Objectives</b>&nbsp;To estimate differences in annual income of physicians in the United States by race and sex adjusted for characteristics of physicians and practices. <b>Design</b>&nbsp;Cross sectional survey study. <b>Setting</b>&nbsp;Nationally representative samples of US physicians. <b>Participants</b>&nbsp;The 2000-13 American Community Survey (ACS) included 43 213 white male, 1698 black male, 15 164 white female, and 1252 black female physicians. The 2000-08 Center for Studying Health System Change (HSC) physician surveys included 12 843 white male, 518 black male, 3880 white female, and 342 black female physicians. <b>Main outcome measures</b>&nbsp;Annual income adjusted for age, hours worked, time period, and state of residence (from ACS data). Income was adjusted for age, specialty, hours worked, time period, years in practice, practice type, and percentage of revenue from Medicare/Medicaid (from HSC physician surveys). <b>Results</b>&nbsp;White male physicians had a higher median annual income than black male physicians, whereas race was not consistently associated with median income among female physicians. For example, in 2010-13 in the ACS, white male physicians had an adjusted median annual income of $253 042 (95% confidence interval $248 670 to $257 413) compared with $188 230 ($170 844 to $205 616) for black male physicians (difference $64 812; P&lt;0.001). White female physicians had an adjusted median annual income of $163 234 ($159 912 to 166 557) compared with $152 784 ($137 927 to $167 641) for black female physicians (difference $10 450; P=0.17). $100 000 is currently equivalent to about £69 000 (€89 000). Patterns were unaffected by adjustment for specialty and characteristics of practice in the HSC physician surveys. <b>Conclusions</b>&nbsp;White male physicians earn substantially more than black male physicians, after adjustment for characteristics of physicians and practices, while white and black female physicians earn similar incomes to each other, but significantly less than their male counterparts. Whether these differences reflect disparities in job opportunities is important to determine.
AB1216-HPR A Study of Possible Correlations of Sleep Disturbance with Disease Activity, Psychological State and Health Status in Patients with Rheumatoid Arthritis
Authors: C. Yukioka, H. Nakahara, M. Fusama, K. Yukioka, T. Kuroiwa, T. Yukioka, M. Inoue, T. Nakanishi, N. Takai, K. Higashi, Y. Miura, N. Murata, T. Kuritani, K. Maeda, H. Sano, M. Yukioka
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Sleep disturbance occasionally occurs in patients with rheumatoid arthritis (RA). It is not clear which factor mostly influences sleep disturbance in patients with RA. <h3>Objectives</h3> We evaluated which factors are correlated with sleep disturbance in patients with RA. <h3>Methods</h3> Patients with RA who met the 1987 revised criteria of ACR for RA or the 2010 ACR/EULAR classification criteria for RA were selected for this study. The levels of disease activity of RA was evaluated using swollen joint count (SJC), tender joint count (TJC), evaluator global assessment (EGA) and patient global assessment (PGA). Sleep disturbance was evaluated utilizing the Pittsburgh Sleep Quality Index (PSQI). Psychological factors were examined utilizing the Center for Epidemiological Studies Depression Scale (CES-D), the Hospital Anxiety and Depression Scale-Anxiety-Depression (HADS-D) and Anxiety (HADS-A) and the State-Trait Anxiety Inventory (STAI). Health status was evaluated with Short Form-36 (SF-36). We assessed the correlation of sleep disturbance with disease activity, psychological factors and health status. Data analyses were performed using Spearman correlation analysis. <h3>Results</h3> 112 patients with RA were recruited. Average of age: 54.8 years old, disease duration: 11.4 years, SJC: 2.7, TJC: 2.2, PGA: 23.2mm, EGA: 16.2mm. PSQI was not correlated with age, duration, SJC, TJC and EGA, while it was weakly statistically correlated with PGA (r=0.2592, p=0.0058). With regard to psychological state, PSQI was significantly correlated with CES-D (r=0.5165, p&lt;0.0001), HADS-A (r=0.4139, p&lt;0.0001), HADS-D (r=0.4182, p&lt;0.0001), STAI (State) (r=0.476, p&lt;0.0001), while there was no statistically significant difference between PSQI and STAI (Trait). With regards to health status, physical summary score (PCS) of SF-36 was not correlated with PSQI statistically, while mental summary score (MCS) was significantly correlated with PSQI (r=0.4186, p&lt;0.0001). <h3>Conclusions</h3> Sleep disturbance was more strongly correlated with psychological state rather than disease activity and physical state. Psychological state is correlated with PGA [1] and PGA is reported to be a limiting factor for reaching remission of RA [2]. Addressing sleep disturbance symptoms may improve not only psychological state but also PGA, resulting in achievement of remission. <h3>References</h3> Fusama M, et al. Mod Rheumatol in press. Studenic P, et al. Ann Rheum Dis 2012; 71: 1702-5. <h3>Disclosure of Interest</h3> None declared
A 2.7-kb Portion of the 5′ Flanking Region of the Murine Glycoprotein αIIb Gene Is Transcriptionally Active in Primitive Hematopoietic Progenitor Cells
Authors: Philippe Tropel, Valérie Roullot, Muriel Vernet, Christel Poujol, Hervé Pointu, Paquita Nurden, Gérard Marguerie, Diana Tronik-Le Roux
Journal: Blood (1997)
PTH-253 Pre-operative weight loss in patients undergoing colorectal surgery
Authors: S Barrett, M George, J Aslan
Journal: Gut (2015)

<h3>Introduction</h3> Malnutrition is associated with poorer post-operative outcomes in patients undergoing surgery. Weight loss and nutritional problems are a common occurrence in cancer and IBD (Irritable Bowel Disease). This study examines the effect of weight loss and complications in a lower gastrointestinal (LGI) surgical population. <h3>Method</h3> A prospective observational study was undertaken in patients admitted to a GI Unit at St Thomas’ Hospital (October to December 2014) for emergency and elective surgery. Data on unintentional weight loss (6 months prior to admission), LOS (length of stay), and complication occurrence was collated. <h3>Results</h3> Data on 48 patients was collected; presented in Table 1: <h3>Conclusion</h3> Pre-operative weight loss was associated with increased LOS and complication occurrence in patients undergoing LGI surgery. Early detection and treatment of malnutrition is an essential consideration in the pre-operative optimisation of patients undergoing LGI surgery. Planned elective admissions should have services in place to address nutritional status prior to surgery. Further prospective randomised studies would help elucidate optimal pre-operative nutritional interventions. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Dindo D, Demartines N, Clavien PA. The Clavien-Dindo Classification of Surgical Complications. Ann Surg. 2004;244:931–937
Quantitative Relation between the Number of Organized Centers and Tissue Volume in Regenerating Masses of Minced Body Sections of &lt;italic&gt;Hydra&lt;/italic&gt;
Authors: Chalkley, Harold W.
Journal: JNCI Journal of the National Cancer Institute (1945)

Journal Article Quantitative Relation between the Number of Organized Centers and Tissue Volume in Regenerating Masses of Minced Body Sections of Hydra Get access Harold W. Chalkley Harold W. Chalkley senior physiologist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 6, Issue 3, December 1945, Pages 191–195, https://doi.org/10.1093/jnci/6.3.191 Published: 01 December 1945
Treatment of requests for sex-change surgery with psychotherapy
Authors: M Kirkpatrick, C T Freidmann
Journal: American Journal of Psychiatry (1976)

The authors describe two patients whose requests for sex-change surgery represented crises in sexual identity and anxiety-masking symptoms. Brief psychotherapy enabled these patients to relinquish their belief in a surgical "cure". In evaluating such request, the psychiatrist should consider the patient's total personality rather than focusing on the genuineness of the perceived gender disorder. Whatever the final decision, the opportunity for continued psychotherapy should be provided.
AB0296 The Coagulation State in Female Patients with Rheumatoid Arthritis and Early Atherosclerosis: Table 1.
Authors: N.A. Bashlakova, T.D. Tyabut, A.E. Buglova, E.V. Kundzer
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> It is known that some factors of the fibrinolytic pathway, such as fibrinogen, D-dimer, have been associated with an increased risk of coronary events and stroke. Many publications demonstrated an increase of early development of atherosclerosis in patients with rheumatic diseases. The data have been focused on carotid arterial atherosclerotic alterations, such as intima-media thickness and plaque formation. <h3>Objectives</h3> The aim of our study was to assess the procoagulation state and its assotiation with inflammation in female patients with rheumatoid arthritis (RA) and early atherosclerosis. <h3>Methods</h3> The study included 37 female patients with rheumatoid arthritis (ACR, 1987), mean age 45,0 (33,0; 51,0) years old, disease duration 9,0 (3,0; 14,0) years, disease activity (DAS28=5,37 (4,69; 5,86) points. Twenty-eight healthy women of the same age formed the control group. The levels of platelet cells (PLT), activated partial thromboplastin time (APTP), fibrinogen were determined with coagulation analyser, while D-Dimer, LA, IgG/IgM antibodies to cardiolipin (aCL), β2-glycoprotein-1 (aβ2-GP1), high sensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), were determined with ELISA. The presence of carotid atherosclerotic alterations was revealed ultrasonographically according to standard procedures. <h3>Results</h3> The patients with RA had significantly higher levels of fibrinogen, D-Dimer, LA, aCL IgG, aβ2-GP1 IgG/IgM, hs-CRP, IL-6 and TNF-α than in the control group (Table 1). The atherosclerotic alterations were found in 48,65% patients with RA, 28,57% in the control group. We reveled positive correlation between PLT and DAS28 (r=0,626, p=0,005), aCL IgM (r=0,513, p=0,029), D-Dimer and hs-CRP (r=0,747, p=0,003), DAS28 (r=0,819, p=0,0006) in RA patients with carotid atherosclerosis, that reflects association between prothrombotic and inflammatory markers. <h3>Conclusions</h3> We demonstrated the presence of prothrombotic state in patients with RA, who had higher levels of inflammatory markers too. Thus, we suggest that inflammation can influence the prothrombotic state in patients with RA, induce endothelial dysfunction and, as a result, early development of atherosclerosis. <h3>Disclosure of Interest</h3> None declared