tbuckley/cabot-search huggingface dataset:
The Treatment of Urinary-Tract Infections with a New Antibiotic — Magnamycin
Authors: Howard M. Trafton, Howard E. Lind, Manuel Correia-Branco
Journal: New England Journal of Medicine (1953)

MAGNAMYCIN hydrochloride is a new monobasic antibiotic possessing strong inhibitory activity predominantly against gram-positive bacteria. Preliminary tests on laboratory animals demonstrated that the drug exhibited low toxicity and did not exhibit cross resistance with other antibiotics in general use.¶ In vitro tests showed it to be highly effective against many gram-positive organisms, including enterococci and penicillin-resistant Micrococcus pyogenes (var. aureus), both of which are becoming increasingly difficult to eradicate.In this preliminary report, 15 patients with genitourinary infections were selected for treatment with Magnamycin because the majority had failed to respond to other antibiotics, including sulfonamides, penicillin, streptomycin, aureomycin, . . .
Breast Cancer Screening and Prevention
Authors: Ann B. Nattinger, Julie L. Mitchell
Journal: Annals of Internal Medicine (2016)

This issue provides a clinical overview of breast cancer screening and prevention, focusing on risk assessment, screening, prevention, and practice improvement. The content of In the Clinic is drawn from the clinical information and education resources of the American College of Physicians (ACP), including MKSAP (Medical Knowledge and Self-Assessment Program). Annals of Internal Medicine editors develop In the Clinic in collaboration with the ACP's Medical Education and Publishing divisions and with the assistance of additional science writers and physician writers.
Pediatric Surgery
Authors: W. Hardy Hendren
Journal: New England Journal of Medicine (1973)

MANY changes have occurred in the field of pediatric surgery since it was reviewed 20 years ago in the Journal,1 not only in the methods of treating certain diseases, but also in the development of pediatric surgery as a specialty. In 1955 Potts2 noted that there were then only eight pediatric surgical services in America. Today, most medical schools and major teaching hospitals include a division or department of pediatric surgery. In contrast, a department of pediatric surgery existed at the University of Prague 86 years ago.3 Parallel developments include formation of Sections of Surgery and Urology in the . . .
Oettlé Memorial Fund
Authors: L S Robertson, J F Murray, F Daubenton
Journal: JNCI Journal of the National Cancer Institute (1968)

Journal Article Oettlé Memorial Fund Get access JNCI: Journal of the National Cancer Institute, Volume 40, Issue 5, May 1968, Page 1132, https://doi.org/10.1093/jnci/40.5.1132-a Published: 01 May 1968
OC-033 Outcomes following small intestinal and multivisceral transplantation at addenbrooke’s hospital, cambridge
Authors: CS Rutter, LM Sharkey, E Allen, T Ambrose, S Duncan, J Green, NK Russell, JM Woodward, AJ Butler, SJ Middleton
Journal: Gut (2015)

<h3>Introduction</h3> Small intestinal transplantation was first undertaken in Cambridge in 1991 and with advances in immunosuppression agents, outcomes have improved. We present our survival figures from 2006 to 2014. <h3>Method</h3> A prospective database is used to record all patients who undergo small intestine (SB), liver/small intestine (LSB), modified multivisceral (MMVT – intestine and stomach) and multivisceral (MVT – intestine, stomach and liver) transplantation at Addenbrooke’s Hospital. All grafts may also contain pancreas, kidney and colon. The NHS Blood and Transplant service derived Kaplan-Meier survival curves for all patients undergoing their first transplant procedure between January 2006 and December 2014. <h3>Results</h3> 56 transplant procedures were performed on 50 patients (6 were re-transplanted, all are still alive). 1-year survival in patients transplanted is 92% (SB), 83% (MMVT), 67% (LSB) and 69% (MVT). 5-year survival is 92% (SB), 63% (MMVT) and 27% (MVT) – this data is not available for LSB transplants due to small numbers and follow-up duration of only 14 m. These data compare favourably with international transplant registry 5-year survival figures of 59% (SB) and 22% (MVT).<sup>1</sup>Overall 1-year survival for all patients transplanted in our unit is 76% and 5-year survival is 46%. <h3>Conclusion</h3> Cambridge is one of 2 UK centres performing intestinal transplantation in adults and we are undertaking an increasing number of procedures – 16 in 2013 and 10 in 2014. We are particularly encouraged by our 92% 5-year survival in patients undergoing isolated SB transplantation and would advocate early referral for assessment in patients with Type 3 intestinal failure who develop complications from home parenteral nutrition. Colon is routinely included in the graft to aid fluid balance and does not preclude regular endoscopic surveillance for rejection. We have performed continuity surgery in a number of patients post transplant (transplanted colon to native colon anastomosis) with good outcomes and no anastomotic leaks. Due to complications of the oesophagogastric anastomosis, gastroparesis and increased morbidity and mortality of MVT we are moving towards performing more LSB transplants and will monitor outcomes with interest. Detailed pre-operative assessment, individualised procedures, patient optimisation and an emphasis on the multidisciplinary team are essential when managing these complex patients. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Intestinal Transplant Registry (ITR) – http://www.intestinaltransplant.org/itr/(Accessed May 2014)
Cytochemistry and Morphology of Human Lymph Node Cells Grown &lt;italic&gt;in Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: G. Adolph Ackerman, M. S., Ralph A. Knouff, Ph. D., Herman A. Hoster, M. D.
Journal: JNCI Journal of the National Cancer Institute (1952)

Cytochemistry and Morphology of Human Lymph Node Cells Grown in Vitro Get access G. Adolph Ackerman, M. S., G. Adolph Ackerman, M. S. Departments of Anatomy and Medicine, The Ohio State University, Columbus, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar Ralph A. Knouff, Ph. D., Ralph A. Knouff, Ph. D. Departments of Anatomy and Medicine, The Ohio State University, Columbus, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar Herman A. Hoster, M. D. Herman A. Hoster, M. D. Departments of Anatomy and Medicine, The Ohio State University, Columbus, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1267–1277, https://doi.org/10.1093/jnci/12.6.1267 Published: 01 June 1952 Article history Received: 14 February 1952 Published: 01 June 1952
FRI0397 Obstructive Airway Symptoms (OAS) Precede the Onset and Diagnosis of Primary Sjögren's Syndrome (PSS) by Many Years:
Authors: E. Theander, T. Mandl, C. Turesson, P. Olsson
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Pulmonary involvement is a recognized extra-glandular manifestation of primary Sjögren9s syndrome (pSS). Recently, we demonstrated that chronic obstructive pulmonary disease (COPD) is common in patients with pSS, even in the absence of smoking (1). <h3>Objectives</h3> In a nested case control study, we now investigate the predictive role of obstructive airway symptoms for development of pSS. <h3>Methods</h3> In two population-based surveys [Malmö Preventive Medicine (N=33346) and Malmö Diet &amp; Cancer (N=30447), pulmonary function tests were performed. OAS was defined as either COPD (FEV1 &lt;70% at inclusion) or a history of treatment of asthma/chronic bronchitis. Among survey participants, incident cases of pSS were identified. Four controls for each validated case, matched for sex, year of birth and year of screening, who were alive and free of pSS when the index person was diagnosed with pSS, were selected from the corresponding health survey database. Proportions with vs without a history of OAS or current smoking at inclusion in the health survey in pre-pSS individuals and controls were compared using χ<sup>2</sup>-test. The impact of OAS and smoking history on the risk of pSS was examined in conditional logistic regression analysis. <h3>Results</h3> Sixty-three individuals (8% male, median age at inclusion 51 (29-72) years) were diagnosed with pSS a median of 98 months (3-329) after inclusion and fulfilled the 2002 AECC-criteria for pSS. ANA, RF, anti-Ro and anti-La were positive in 73%, 57%, 59% and 41% respectively. Focal sialadenitis with focus score ≥1 was found in 85%. At inclusion significantly more pre-pSS individuals had OAS compared to controls: 21% vs 8%, p=0.014. OR 3.1 (95% CI 1.3-7.5). While in healthy controls there was a clear association between current smoking and OAS (p=0.031), in pre-pSS individuals smoking did not influence the presence of OAS (p=0.45). In multivariate analysis, OAS and being non-smoker independently predicted development of pSS during follow-up. <h3>Conclusions</h3> Presence of obstructive airway symptoms in pre-pSS individuals increases the risk of pSS independently of smoking habits, while being current smoker seems to lower it. These data confirm results from our earlier cross-sectional and retrospective studies, both with regard to COPD and smoking (1,2). Airway inflammation, unrelated to smoking, may be a very early step in the development of pSS. <h3>References</h3> Nilsson A. et al, J Rheumatol 2015; Jan 15. pii: jrheum.140370. [Epub ahead of print], Manthorpe R. et al. Ann Rheum Dis 2000; 59: 54-60 <h3>Disclosure of Interest</h3> None declared
SAT0052 Comparison of Physical Activity and Level of Fatigue Among Patients with Rheumatoid Arthritis and the General Dutch Population
Authors: J. Weijers, S. Rongen-van Dartel, H. Repping-Wuts, J. van Kuijk, T. Galesloot, A. Verbeek, P. van Riel, J. Fransen
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Besides pain, patients with rheumatoid arthritis (RA) mention fatigue as the most important complaint. Many RA patients experience fatigue, which may be caused by their disease. However, many people in the general population are also fatigued; it is unclear whether fatigue indeed is more severe in RA patients than in the general population. Fatigue may be related to the level of physical activity (PA); while RA patients may be less physically active compared to the general population, it is useful to estimate the size of the "gap". <h3>Objectives</h3> 1) to compare the level of PA and the level of fatigue between RA patients and the general Dutch population and 2) to investigate the relation between the level of PA and fatigue in both groups. <h3>Methods</h3> Data representative of the general Dutch population were obtained as part of the Nijmegen Biomedical Study (NBS) in 2012, a population-based survey among randomly selected inhabitants of the municipality of Nijmegen (n=3764). 740 RA patients across the Netherlands filled in an online survey in 2013 and 2014. Self-reported PA was assessed using the Short Questionnaire to Assess Health (SQUASH) Enhancing PA. This Dutch questionnaire contains questions about PA divided over four categories. Total amount of PA in minutes per week was calculated. Fatigue was assessed using the Dutch 'Shortened fatigue questionnaire' (SFQ), whereby a higher score indicates a more severe level of fatigue. <h3>Results</h3> RA patients on average had 1642±1167 (Mean ± SD) minutes of PA per week which was lower (p&lt;0.001) than the general population with 2079±1364 (Mean ± SD) minutes per week, also in all four categories of activities (p&lt;0.05). In comparison with the general Dutch population, RA patients had a higher fatigue level (p&lt;0.001), with median (IQR) SFQ scores of 9 (6-15) and 16 (11-22) respectively. Corrected for gender, age and BMI, partial correlation established a significant negative relationship between fatigue as independent variable and PA as dependent variable in RA patients (r=-0.174, p&lt;0.001) as well as in the general Dutch population (r=-0.074, p&lt;0.001). <h3>Conclusions</h3> In comparison with the general Dutch population, RA patients showed higher levels of fatigue and were less physically active; less PA was associated with a higher level of fatigue, and this association was more than twice as strong in RA patients compared with the general Dutch population. <h3>Disclosure of Interest</h3> None declared
Chronic Prostatitis and Prostatodynia: Ultrasonographic Alterations of the Prostate, Bladder Neck, Seminal Vesicles and Periprostatic Venous Plexus
Authors: D. Di Trapani, C. Pavone, V. Serretta, N. Cavallo, G. Costa, M. Pavone-Macaluso
Journal: European Urology (1988)
Risk Factors for Severe Renal Disease in Bardet–Biedl Syndrome
Authors: Elizabeth Forsythe, Kathryn Sparks, Sunayna Best, Sarah Borrows, Bethan Hoskins, Ataf Sabir, Timothy Barrett, Denise Williams, Shehla Mohammed, David Goldsmith, David V. Milford, Detlef Bockenhauer, Lukas Foggensteiner, Philip L. Beales
Journal: Journal of the American Society of Nephrology (2016)

Bardet-Biedl syndrome is a rare autosomal recessive, multisystem disease characterized by retinal dystrophy, renal malformation, obesity, intellectual disability, polydactyly, and hypogonadism. Nineteen disease-causing genes (
Abstract 228: Cardioprotection Of Recombinant Human Mg53 Protein In A Porcine Model Of Ischemia And Reperfusion Injury
Authors: Hua Zhu, Jianxun Liu, Yongqiu Zheng, Lei Li, Tao Tan, Ki Ho Park, Jincai Hou, Zhengguo Liu, Jianjie Ma
Journal: Circulation Research (2014)

Rationale: Ischemic heart disease is a leading cause of death in human population and protection of myocardial infarction (MI) associated with ischemia-reperfusion (I/R) injury remains a challenge. MG53 is an essential component of the cell membrane repair machinery that protects injury to the heart. Objective: We investigated the therapeutic value for using the recombinant human MG53 (rhMG53) protein for treatment of MI. Methods and Results: Using Langendorff perfusion of isolated mouse heart, we found that I/R caused injury to cardiomyocytes and release of endogenous MG53 into the extracellular solution. The exogenous rhMG53 protein applied to the perfusion solution could concentrate at injury sites on the cardiomyocytes to facilitate cardioprotection. With rodent models of I/R-induced MI, we established the in vivo dosing range for rhMG53 in cardioprotection. Using a porcine model of angioplasty-induced MI, the cardioprotective effect of rhMG53 was evaluated. Intravenous administration of rhMG53, either prior to or post ischemia, reduced the infarct size and troponin I release in the porcine model when examined at 24 hrs post reperfusion. Biochemical study showed that the systemically delivered rhMG53 localized to the acute infarct zone of the porcine heart. Echocardiogram and histological analyses revealed that the protective effects for rhMG53 observed following acute MI led to long-term improvement in cardiac structure and function in the porcine model when examined at 4 weeks post operation. Conclusions: Cardioprotection of rhMG53 in porcine model supports the concept that rhMG53 protein could have therapeutic value for treatment of MI in human patients with ischemic heart disease.
Clinical Neisseria gonorrhoeae isolate with a N. meningitidis porA gene and no prolyliminopeptidase activity, Sweden, 2011 – danger of false-negative genetic and culture diagnostic results
Authors: D Golparian, E Johansson, M Unemo
Journal: Eurosurveillance (2012)

We describe a Neisseria gonorrhoeae strain, found in Sweden in 2011, that harbours a N. meningitidis porA gene causing false-negative results in PCRs targeting the gonococcal porA pseudogene. Furthermore, the strain had no prolyliminopeptidase (PIP) activity that many commercial biochemical kits for species verification in culture rely on. Enhanced awareness of the spread of such strains and screening for them can be crucial.
Cultural Competency
Authors: Marjorie S Rosenthal
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Histopathology of Tumors Induced in Mice Treated With Polyoxyethylene Sorbitan Monostearate&lt;xref ref-type="author-notes" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Giuseppe della Porta, Benedetto Terracini, Kai Dammert, Philippe Shubik
Journal: JNCI Journal of the National Cancer Institute (1960)

A morphological study is presented of different types of skin tumors induced after repeated applications of polyoxyethylene sorbitan monostearate under various conditions. The tumors have been classified as papillomas, acanthomas, keratoacanthomas, benign adnexal tumors, squamous-cell carcinomas, and basal-cell carcinomas. Particular attention has been paid to the papillomas that regress; a series of papillomas studied before the time of maximum regression exhibited inflammatory changes that are described.
Descending Sphincterotomy of the Papilla of Vater Through a Choledochoduodenostomy Under Endoscopic View
Authors: D. Wurbs, F. Hagenmüller, M. Classen
Journal: Endoscopy (1980)

Endoscopic papillotomy required deep cannulation of the papilla of Vater. But retrograde placing of the papillotome in the distal common bile duct is not always possible. Occasionally conditions permitting a descending antegrade cannilation of the papilla are found. An existing choledochoduodenostomy can be used as access for such a cannulation from above. A papillotome, type Erlangen, introduced into the papilla from above, spontaneously adopts the correct cutting direction. With regard to its length the incision has, however, to be monitored endoscopically. Also, undesired additional burns in the duodenum only can be avoided by endoscopic control. This may require the use of a second instrument. The technique described above was successfully applied as another variant of descending papillotomy.
Into the Woods
Authors: Nasia Safdar, Daniel R. Kaul, Sanjay Saint
Journal: New England Journal of Medicine (2007)

A 79-year-old woman presented with a 1-month history of dyspnea and cough productive of yellow sputum. She reported no chest pain, hemoptysis, night sweats, or fever. She was receiving 40 mg of oral prednisone daily for giant-cell arteritis.
First presentation of malignancy to the emergency department: An analysis of patient demographics and cancer stage in an Irish tertiary referral center in a low income area.
Authors: Daniel Iliev Angelov, MinYuen Teo, John McCaffrey
Journal: Journal of Clinical Oncology (2015)

e12616 Background: Rapid access pathways were set up to improve cancer diagnosis as prompt diagnosis might facilitate curative treatments. Nevertheless, emergent presentations via emergency departments are still common. We sought to delineate characteristics of new cancer diagnoses presented via emergency department in a low income, inner city setting with a catchment population of 180,000, and examine potential barriers. Methods: Data on all medical oncology consultations over a 3 months period were reviewed. Electronic health records were used to determine whether a consultation was for a first presentation of malignancy from the emergency department. Patient age, gender, cancer type, cancer stage, date of biopsy, date of radiological staging and social history were obtained. Results: Seventy patients were referred to the medical oncology service, with 29 patients (41%) having a first diagnosis of malignancy. Median age was 76 years (range: 44 – 94). In total, 19 cases were female (66%) while 10 were male (34%). The 4 most common cancers were colorectal (21%), lung (17%), cholangiocarinoma (10%) and ovarian (10%) cancers. 93% of these patients were metastatic at presentation. One patient had no documented evidence of histologic confirmation and 5 patients (17%) did not complete radiologic staging. 62% of new presentations were unmarried while 44.8% lived alone. Conclusions: Our data suggests that patients who present via emergency department as first manifestation of their cancer are more likely to be older and single, and have advanced disease. Increased awareness of rapid access clinics and bowel screening programs might be crucial public health measures. We are currently expanding the study to examine a 12 month period.
Expression of AC133, a Novel Stem Cell Marker, on Human Leukemic Blasts Lacking CD34− Antigen and on a Human CD34+ Leukemic Cell Line: MUTZ-2
Authors: Karsten Kratz-Albers, Michael Zühlsdorf, Regine Leo, Wolfgang E. Berdel, Thomas Büchner, Hubert Serve
Journal: Blood (1998)
Survival advantage with para aortic lymphadenectomy in peri-ampullary cancer: A retrospective cohort study
Authors: Abu Bakar Hafeez Bhatti, Faisal Saud Dar, Eraj Sahaab, Nusrat Yar Khan, Haseeb Zia, Atif Rana, Muhammad Salih, Najmul Hassan Shah
Journal: International Journal of Surgery (2016)
Leaders or Lemmings?
Authors: M Linzer
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal