tbuckley/cabot-search huggingface dataset:
FRI0558 From Perspective of DN4 and Lanss Scales, Does Single Steroid Injection Really Relieves Neuropathic Pain in Carpal Tunnel Syndrome?: Table 1.
Authors: T. Dandinoglu, M. Karadeniz, V. Yilmaz
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Since 2001, neuropathic pain scales have been used in the assessment and follow-up of neuropathic pain. DN4 and LANSS pain questionnaires have been applied to groups, mostly consisted of radiculopathy and polyneuropathy cases, before and after various treatments and the results have been compared with the electrophysiologic findings. However to our knowledge there is yet no such study focusing on neuropathic complaints and the relationship between neuropathic pain and electrophysiological findings before and after local corticosteroid injection. <h3>Objectives</h3> The purpose of this study was to evaluate the neuropathic symptoms after local steroid injection in CTS. <h3>Methods</h3> Forty-one patients aged 22-65 years and diagnosed with carpal tunnel syndrome by nerve conduction studies who were also found to have a neuropathic symptoms were included in the study. All patients received local steroid injection into the carpal tunnel while the questionnaires and nerve conduction studies were performed before and 2 months after the injection. <h3>Results</h3> DN4 and LANSS scale scores were significantly reduced after single local steroid injection (p&lt;0.05)(Table 1). <h3>Conclusions</h3> Besides clinical and functional effects, minimally invasive local steroid injection also appears to be effective for neuropathic complaints in terms of DN4 and LANSS scale9s scores. <h3>Disclosure of Interest</h3> None declared
SP0227 Case 1 Presentation: Arthritis, Lupus and More. Rhupus or Polyautoimmunity?
Authors: C. Duarte-Rey
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Introduction</h3> Autoimmune disease (AD) may well start off as a single diagnosis and across the years develop into multiple autoimmune syndromes (MAS) seen in the same patient, as new clinical symptoms and laboratory finding show up in the course of disease. Multiple environmental exposures to infectious disease, tobacco smoking, and pharmacological interventions might only be important in defining the course of AD based on genetic susceptibility and phenotypic manifestations. This is the clinical case of a mature adult male patient, now forty-four years old with a family history of systemic lupus erythematosus (SLE) in mother and autoimmune thyroid disease (AITD) in a sibling. In 2002 he was initially diagnosed with rheumatoid arthritis (RA) and has by now more than a decade later, already progressed to multiple manifestations of SLE and Sjögren9s Syndrome (SS). <h3>Case description</h3> We will discuss a forty-four year old male, patient who starts manifesting inflammatory polyarthralgias in knees and ankles associated with morning stiffness in the year 2000. After multiple consultations he was diagnosed in 2002 with RA. At his point he was found to have non erosive arthritis, high titles of rheumatoid factor and positive anti-CCP antibodies. Of interest, he had a past medical history of tropical disease while on military service of malaria, typhoid fever, and cutaneous leishmaniasis when he was in his early twenties. Since teenage years and until 2008, he was exposed to tobacco smoking and moderate weekly alcohol consumption. Familial history of AD has been identified in his mother who had SLE and on a sister with AITD. After being diagnosed with RA he was started on steroids and non-biologic DMARDs with partial and intermittent remission of disease. 5 years later after diagnosis he developed dry symptoms consistent with dry mouth and dry eyes and by 2008 SS was diagnosed after a positive Schirmer test, a minor salivary gland biopsy disclosing severe chronic sialadenitis and positive anti-Ro and anti-La antibodies. That same year polyarthralgia was now in hands, wrists, elbows and shoulders, associated with myalgia, hair loss, and Raynaud9s phenomenon, which were all previously absent. In 2009 he was started in anti-TNF biological treatment, which he received for 9 months. After failing remission of disease new laboratory workup was gathered. He tested positive for antinuclear antibody (ANA), showed new lymphopenia, and now also had positive anti-Sm, anti-RNP antibodies. SLE/Rhupus was now diagnosed. Therapy with anti-CD20 was initiated and a year later he tested positive for IgG anticardiolipine and showed CH-50 complement consumption. ENA panel at this point tested all negative, while ANA where still positive. Until now this patient has been a therapeutical challenge as articular manifestations persist along with undesired drug side effects of continued treatment. <h3>Disclosure of Interest</h3> None declared
Outbreak of legionnaire’s disease in two groups of tourists staying at camp sites in France
Authors: A Infuso, B Hubert, D Dumas, M Reyrolle, S De Mateo, C Pelaz, C Hemery, I Pérez
Journal: Eurosurveillance (1997)

On 11 June 1996, three suspected cases of legionnaires disease in a group of 42 Dutch tourists were reported to the local public health authority by Millau hospital in south west France. The group (group 1) had been touring with caravans and staying at d
Enzyme-Controlled Intracellular Self-Assembly of <sup>18</sup>F Nanoparticles for Enhanced MicroPET Imaging of Tumor
Authors: Yaling Liu, Qingqing Miao, Pei Zou, Longfei Liu, Xiaojing Wang, Linna An, Xiaoliu Zhang, Xiangping Qian, Shineng Luo, Gaolin Liang
Journal: Theranostics (2015)

Herein, we report the development of a new "smart" radioactive probe (i.e., 1) which can undergo furin-controlled condensation and self-assembly of radioactive nanoparticles (i.e., 1-NPs) in tumor cells and its application for enhanced microPET imaging of tumors in nude mice co-injected with its cold analog (i.e., 1-Cold). Furin-controlled condensation of 1-Cold and self-assembly of its nanoparticles (i.e., 1-Cold-NPs) in vitro were validated and characterized with HPLC, mass spectra, SEM, and TEM analyses. Cell uptake studies showed that both 1 and 1-Cold have good cell permeability. TEM images of 1-Cold-treated MDA-MB-468 cells directly uncovered that the intracellular 1-Cold-NPs were at/near the location of furin (i.e., Golgi bodies). MTT results indicated that 50 µM 1-Cold did not impose cytotoxicity to MDA-MB-468 cells up to 12 hours. MicroPET imaging of MDA-MB-468 tumor-bearing mice indicated that mice co-injected with 1 and 1-Cold showed higher uptake and longer attenuation of the radioactivity in tumors than those mice only injected with same dosage of 1. Tumor uptake ratios of 1 between these two groups of mice reached the maximum of 8.2 folds at 240 min post injection. Biodistribution study indicated that the uptake ratios of 1 in kidneys between these two groups continuously increased and reached 81.9 folds at 240 min post injection, suggesting the formation of radioactive NPs (i.e., 1-NPs) in MDA-MB-468 tumors of mice co-injected with 1 and 1-Cold. And the nanoparticles were slowly digested and secreted from the tumors, accumulating in the kidneys. Our ''smart'' probe (i.e., 1), together with the strategy of co-injection, might help researchers trace the biomarkers of interest within a longer time window.
HLA-A0201-positive, IL-7/B7.1-cotransfected allogeneic tumor cells as a vaccine in metastatic renal cell cancer—A clinical phase-I trial
Authors: A. Floercken, J. Kopp, R. Schabath, K. Joehrens-Leder, H. Pohla, D. Schendel, T. Blankenstein, B. Dörken, J. Westermann, A. Pezzutto
Journal: Journal of Clinical Oncology (2007)

3072 Background: Tumor vaccination remains a promising experimental approach in RCC. HLA-A0201-restricted T cell immunity against RCC is well established. RCC26 is an allogeneic HLA-A0201+ human RCC cell line, a T cell clone specifically recognising RCC26 and other RCC in the context of HLA-A0201 has previously been generated, the TCR of this T cell clone was characterised. Furthermore, IL-7/B7.1 cotransfected tumor cells are a potent vaccine in animal models. Methods: RCC26 was transfected with pKEx-IL-7-IR-B7 coding for human IL-7 and B7.1 (CD80). 10 HLA-A0201+ patients with metastatic RCC and disease progression under cytokine therapy were included. 10 vaccinations with 2.5–40x10 6 gene-modified irradiated tumor cells which had been produced under GMP conditions were performed s.c. over 22 weeks. Primary endpoints of the study were feasibility, safety and immunological response, secondary endpoint was clinical response. The protocol was approved by the ethics committee, all patients gave informed consent. Results: Gene-modified RCC26 cells produced IL-7 (3.4 ng/10 6 cells/24h), more than 90% of the cells were CD80+. Vaccination was feasible and safe with no severe toxicity. Local DTH-reactions were observed in 4 patients. Skin biopsies of the vaccination site showed lymphocytic infiltrates dominated by CD4+T cells. In 8 patients vaccination induced HLA- and /or antinuclear antibodies without clinical signs of autoimmunity. Analysis of the T cell response against RCC-associated antigens is under way. No partial or complete responses could be documented. However, 50% of the patients had stable disease with the longest TTP being 69 weeks. Mean TTP in our cohort was 25 weeks (range 4 to 69 weeks). Conclusion: Our results show that vaccination with an allogeneic gene-modified tumor cell line is feasible and safe. Stable disease lasting up to 69 weeks in a substantial proportion of patients suggests immunological activity of the vaccine. Vaccination of patients with a low tumor burden is a promising strategy for the future, i.e. after surgery or treatment with novel multi-kinase inhibitors. No significant financial relationships to disclose.
Cerebrospinal fluid opioid activity in anorexia nervosa
Authors: W H Kaye, D Pickar, D Naber, M H Ebert
Journal: American Journal of Psychiatry (1982)

The authors found higher levels of CSF opioid activity, determined by radioreceptor assay, in patients with anorexia nervosa who were severely underweight than in 1) the same patients after weight restoration and 2) normal controls. Another group of patients who had chronic anorexia nervosa but were not severely underweight had normal levels of CSF opioid activity. Endogenous opioid systems have been shown to be related to eating behavior and metabolic regulation in animals. The association between decreased weight and increased CSF opioid activity observed by the authors may be a compensatory response to weight loss or may be etiologically related to anorexia nervosa.
Depression, demographic dimensions, and drug abuse
Authors: W Dorus, E C Senay
Journal: American Journal of Psychiatry (1980)

The authors examined the relationship between depressive symptoms, drug-use pattern, and demographic variables in 432 substance abusers. Assessment was at intake and at 4 and 8 months. Depression was measured by using the Beck Depression Inventory, the Hamilton Rating Scale for Depression, and the Current and Past Psychopathology Scales. At intake 46% of the subjects reported moderate or high levels of depression on the Beck scale and 29% of subjects scored in the high or moderate range of depression on the Hamilton scale. After eight months, depression scores were significantly lower in all drug abuse groups. These reducations were not related to type or length of treatment.
Intramucosal Adenocarcinoma of the Appendix: How to Find and How to Treat
Authors: I. Sakamoto, S. Watanabe, T. Sakuma, M. Igarashi, J. Koike, T. Shirai, S. Sadahiro, M. Nakamura, T. Mine
Journal: Endoscopy (2003)

A colonoscopic examination of a 58-year-old man revealed a small elevated lesion inside the orifice of the appendix. Using a polypectomy snare, a nodular polypoid lesion with a diameter of ca. 20 mm was removed from the lumen of the appendix. Histopathology showed that it was a well-differentiated adenocarcinoma. This is the first report of an intramucosal adenocarcinoma of the appendix diagnosed preoperatively; laparoscopy-assisted colectomy with a D2 lymph-node dissection was carried out. Endoscopists should consider an appendiceal tumor when an erosion, elevation, or deformity is seen in the head of the cecum.
Prognostic Factors, Treatment, and Survival in Dermatofibrosarcoma Protuberans
Authors: Maressa C. Criscito, Kathryn J. Martires, Jennifer A. Stein
Journal: JAMA Dermatology (2016)

There is limited information regarding the influence of patient demographics, tumor characteristics, and treatment type on the survival of patients with dermatofibrosarcoma protuberans (DFSP).To assess prognostic factors and to evaluate the influence of treatment modality on overall survival of patients with DFSP.We examined DFSP using data for 3686 patients with histologically confirmed cases of DFSP diagnosed between 1972 and 2012 from the 18 US regional registries of the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program, with linkage to demographic data from the US Census Bureau for median household income (MHI). The analysis was performed in February 2016.The primary outcome measures were tumor characteristics, prognostic factors, and overall survival in months.There were 3686 cases of DFSP examined. Older age (hazard ratio [HR], 1.08; 95% CI, 1.06-1.10; P < .001), male sex (HR, 1.97; 95% CI, 1.09-3.55; P = .03), and tumor size (HR, 1.09; 95% CI, 1.01-1.18; P = .04) were significantly associated with poorer overall survival in a controlled analysis. Older age (odds ratio [OR], 1.01; 95% CI, 1.00-1.02; P = .01), male sex (OR, 1.95; 95% CI, 1.57-2.42; P < .001), and black race (OR, 1.78; 95% CI, 1.37-2.32; P < .001) were associated with larger (≥3.0 cm) tumors at presentation. Treatment modality did not influence overall survival; however, differences in patient characteristics affected the treatment received. Older age at presentation (OR, 1.02; 95% CI, 1.01-1.03; P =.01), black race (OR, 1.82; 95% CI, 1.13-2.92; P = .01), large tumor size (OR, 1.15; 95% CI, 1.09-1.21; P < .001), and head or neck location (OR, 4.63; 95% CI, 2.66-8.07; P <.001) increased the likelihood of a patient receiving surgery and radiation over surgery alone. In addition, white patients (OR, 0.51; 95% CI, 0.30-0.87; P=.01), women (OR, 0.53; 95% CI, 0.36-0.78; P <.001), and patients with a higher MHI (OR, 1.27; 95% CI, 1.11-1.46; P <.001) were more likely to receive Mohs micrographic surgery (MMS) over excision.Age at diagnosis, male sex, and DFSP tumor size appear to be important prognostic factors. Treatment modality did not significantly influence survival; however, patient and tumor characteristics influence treatment modality.
SP0153 Social and Work Participation – Research into Practice
Authors: R. Wilkie
Journal: Annals of the Rheumatic Diseases (2015)

Social participation is important for wellbeing and healthy ageing. Older adults with musculoskeletal conditions are particularly vulnerable to reduced social participation due to retirement from work and the impact of physical disability. Sixty percent of over 65s with musculoskeletal conditions do not participate socially as they would like to. In older people, low social participation is associated with depression and predicts poor mental health related quality of life. Maintaining social participation is associated with improved outcomes: higher levels of social participation at baseline were associated with lower levels of hypertension, obesity and inflammatory markers (C-reactive protein and fibrinogen) at two year follow-up in the English Longitudinal Study of Ageing, and lower mortality rates in the British Women9s Heart and Health Study and community dwelling older adults in the United States. This session will offer opportunities and encourage clinicians and researchers to assess participation in social activities and social roles. It will look at the importance, measurement in clinical practice, and ways to maintain social roles and participation. Pertinent to the chronicity of many musculoskeletal conditions, approaches to maintain participation in life despite the experience of joint symptoms will be highlighted. <h3>Disclosure of Interest</h3> None declared
Mumps outbreak ongoing since October 2007 in the Republic of Moldova
Authors: H Bernard, N G Schwarz, A Melnic, V Bucov, N Caterinciuc, R  G Pebody, M Mulders, C Aidyralieva, S Hahné
Journal: Eurosurveillance (2008)

The Republic of Moldova is experiencing a nationwide mumps outbreak, with a total of 19,550 notified cases as of 23 March 2008. The outbreak started in October 2007, with 105 cases notified in that month compared to an average number of 24 cases per month notified between January and September 2007. Between 1 October and 31 December 2007, 1,524 cases were notified.
Endpiece: The fully established physician
Authors: Jeremy Hugh Baron
Journal: BMJ (2005)

We sometimes see a remarkable difference between the behaviour of a physician at his first setting out and afterwards when he is fully established in reputation and practice. In the beginning he is affable, polite, humane, and assiduously attentive to his patients; but afterwards, when he has reaped the fruits of such behaviour, and finds himself independent, he assumes a very different tone, he becomes haughty, rapacious, careless, and often somewhat brutal in his manner. Conscious of the ascendancy he has acquired, he acts a despotic part, and takes a most ungenerous advantage of the confidence which people have in his abilities.

Gregory J. Lectures on the duties and qualifications of a physician. London: W Strahan and T Cadell, 1772: 25
Localization of Parathyroid Adenoma With Real-Time Ultrasound
Authors: Christina Bluemel, Paul Kirchner, Georg W. Kajdi, Rudolf A. Werner, Ken Herrmann
Journal: Clinical Nuclear Medicine (2015)

Preoperative localization of parathyroid adenoma in primary hyperparathyroidism gains in importance as there is a trend toward minimally invasive parathyroid surgery. Besides MRI, 4-dimensional CT, PET/CT, invasive-selective venous sampling, or angiography, both ultrasound and scintigraphy are standard of care for lesion localization. Here we report on a 53-year-old woman with suspicion of primary hyperparathyroidism using real-time fusion of scintigraphic (freehand SPECT) and ultrasound imaging for adenoma localization. Real-time fusion of ultrasound and freehand SPECT allowed noninvasive dedicated metabolic and anatomic adenoma localization and treatment planning.
Relationship between physical anomalies and age at onset of schizophrenia
Authors: M F Green, P Satz, H V Soper, F Kharabi
Journal: American Journal of Psychiatry (1987)

Among 50 schizophrenic patients grouped by age at onset, the group with onset at or before age 18 had significantly more subjects with minor physical anomalies. These findings suggest that early-onset schizophrenia is associated with a more compromised CNS.
Adaptive control with feedback of suramin using intermittent infusions.
Authors: W D Figg, J A Stevens, M R Cooper
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.7.1523 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8021743 Adaptive control with feedback of suramin using intermittent infusions. W D FiggxW D FiggSearch for articles by this author , J A StevensxJ A StevensSearch for articles by this author , M R CooperxM R CooperSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.7.1523 PDF "Adaptive control with feedback of suramin using intermittent infusions.." Journal of Clinical Oncology, 12(7), pp. 1523–1524© 1994 by American Society of Clinical Oncology
AB0762 Comparison of Clinical and Ultrasound (US) Lesions of Plantar Aponeurosis in Patients with Early Spondyloarthritis (ESPA):
Authors: D. Anastasiya, D. Tatiana, E. Shandor, R. Oxana, G. Elena, S. Sergey, P. Olga
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To study the compliance of clinical and US lesions of plantar aponeurosis in patients with eSpA. <h3>Methods</h3> The study included 126 patients with eSpA (the average age is 28.9±7.3 years): 72 (58.2%) patients with axial spondyloarthritis (aSpA, ASAS 2009) and 54 (41.8%) with peripheral (pSpA, ASAS 2011). 58.7% of them were women, 84.2% were HLAB27 positive. The study was included clinical (heel pain when walking and palpation) and US examination of the heel (thickening of the plantar aponeurosis, heterogeneity, insertion of plantar aponeurosis into calcaneal bone). US investigation was performed by MyLab Twice ultrasound device (Esaot, Genova, Italy). Disease activity was measured by BASDAI, BASFI and ASDAS<sub>CRP</sub> scales. <h3>Results</h3> 110 out of 126 patients (87.3%) had no clinical signs of plantar fasciitis, 16 (12.7%) patients had heel pain when walking and palpation, US lesions of plantar fasciitis were found in 41 (32.5%) patients. 31 (28.2%) out of 110 patients without pain had US signs of plantar fasciitis. 11 (68.7%) out of 16 patients with pain syndrome had US signs of plantar fasciitis. 126 patients were divided into 4 groups; data are presented in table 1. A comparative analysis of the disease activity between different groups of patients has shown that patients of group 1 with heel pain syndrome and US lesions indexes of activity were significantly higher than in other groups. BASDAI (p=0.001). ASDAS<sub>CRP</sub> (p=0.003). Also patients in group 3 with pain syndrome, but without US signs of plantar fasciitis had higher indexes of activity. <h3>Conclusions</h3> The study revealed a discrepancy between clinical and US lesions of plantar fascia: clinical signs of inflammation were founded in 12.7% of cases, and US signs in 32.5% of patients. Among patients without pain 28.2% had signs of plantarn fasciit. Indexes of activity were significantly higher in patients with pain, even without US lesions of plantarn fascia. <h3>Disclosure of Interest</h3> None declared
Adults' recollection of their language deprivation as immigrant children
Authors: L R Marcos
Journal: American Journal of Psychiatry (1982)

For this retrospective study, six adult patients in psychoanalytic psychotherapy participated in 45-min audiotaped individual sessions that focused on their reaction to the language deprivation they experienced following their immigration to the United States during their later childhood years. The content analysis of these sessions showed that all six patients experienced the impact of language deprivation in a strikingly similar way. Four consecutive stages were identified: withdrawal, despondency, adaptation, and integration. On the basis of these preliminary observations, the author makes tentative recommendations aimed at ameliorating the consequences of language deprivation in immigrant children and suggests systematic research on these children.
Interpersonal relatedness and paranoid schizophrenia [clinical conference]
Authors: W Sobel, R Wolski, R Cancro, G J Makari
Journal: American Journal of Psychiatry (1996)

A 33-year-old man presented with a 10-year history of psychosis and an imaginary companion; he carried a past diagnosis of chronic schizophrenia. He responded quickly to neuroleptic and was noted to be an easily engageable person. It is argued that despite his first-rank Schneiderian symptoms, the patient may not best be conceptualized as having schizophrenia. Specific treatment recommendations are made, predicated on this man's developmental history, his attachment and separation behavior, and his response to a structured social milieu.