tbuckley/cabot-search huggingface dataset:
Normalization of Low-Density-Lipoprotein Levels in Heterozygous Familial Hypercholesterolemia with a Combined Drug Regimen
Authors: John P. Kane, Mary J. Malloy, Peggy Tun, Nancy R. Phillips, Donna D. Freedman, Mary L. Williams, Jane S. Rowe, Richard J. Havel
Journal: New England Journal of Medicine (1981)

We studied the effect of the bile acid sequestrant colestipol, alone and in combination with clofibrate or niacin, in patients with heterozygous familial hypercholesterolemia who were given a diet low in cholesterol and saturated fat. With colestipol alone, mean cholesterol levels in serum decreased 16 to 25 per cent. The addition of clofibrate produced a total mean decrement of only 28 per cent. In contrast, serum cholesterol levels fell 45 per cent when colestipol was combined with niacin. Low-density-lipoprotein (LDL) cholesterol decreased 55 per cent with colestipol and niacin, whereas highdensity-lipoprotein (HDL) cholesterol increased. Mean LDL cholesterol was lower in patients given this regimen than in matched normal controls eating an unrestricted diet. Tendinous xanthomas, measured by quantitative xeroradiography, were significantly reduced (P<0.01), indicating that this regimen mobilized cholesterol from tissue pools with slow turnover. Colestipol plus niacin promises to be useful in the treatment of patients at high risk from elevated levels of LDL. (N Engl J Med. 1981; 304:251–8.)
Abstract 223: ΔNp63α, a p53 family member protein, promotes tumor progression in pancreatic cancer
Authors: Alexey Danilov, Divas Neupane, James DiRenzo, Murray Korc
Journal: Cancer Research (2011)

Abstract Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related deaths in both men and women. Targeted therapies thus far have failed to demonstrate survival advantage in PDAC and novel therapies are needed. Mutations in Ras and p53 are frequently found in PDAC and promote cancer cell survival, invasiveness and chemoresistance. In contrast, p63, an ancestral member of p53 family, is rarely mutated in cancer. ΔNp63α was shown to be overexpressed in squamous cell tumors of the lung and head and neck and thus has been implicated in carcinogenesis. We tested expression of p63 isoforms in five PDAC cell lines and investigated its role in tumor progression. Expression of p63 was determined by immunoblotting, real-time quantitative and semi-quantitative PCR in 5 PDAC cell lines. PANC-1 cells, with low levels of p63, were transfected with ΔNp63α cDNA-expressing vector. Conversely, high endogenous p63 levels in T3M4 and BxPC3 cell lines were suppressed by specific shRNA. We studied cell proliferation in a doubling assay, motility in wound assay and invasiveness in Matrigel chambers. We found that pancreatic cancer cell lines predominantly expressed ΔN isoform of p63, and specifically ΔNp63α variant. ΔNp63α protein and transcript levels were high in T3M4, BxPC3 and Colo-357 cell lines and low in ASPC-1 and PANC-1 cell lines. Interestingly, transcript levels of TAp63, a p63 variant implicated in cellular senescence and suppression of metastases, were near the detection threshold in all cell lines. Overexpression of ΔNp63α in PANC-1 cells resulted in increased proliferation and enhanced migration of those cells but had no effect on invasiveness in serum-free conditions. Incubation of ΔNp63α-expressing PANC-1 cells in presence of epidermal growth factor increased both migration and invasiveness. By contrast, shRNA knockdown of endogenous p63 in BxPC3 cells led to decreased proliferation. Silencing p63 in T3M4 cells resulted in attenuated migration in serum-free conditions and decreased migration and invasiveness in response to epidermal growth factor. Thus, ΔNp63α is a predominantly expressed isoform of p63 in PDAC cell lines. ΔNp63α plays an important role in PDAC progression and thus its associated pathways may potentially be therapeutically targeted in this disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 223. doi:10.1158/1538-7445.AM2011-223
Predicting Risk for Late Metastasis: the PAM50 Risk of Recurrence (ROR) Score After 5 Years of Endocrine Therapy in Postmenopausal Women with Hr+ Early Breast Cancer: a Study On 1,478 Patients from the Abcsg-8 Trial
Authors: M. Gnant, M. Filipits, P. Dubsky, M. Rudas, M. Balic, R. Greil, S. Ferree, J.W. Cowens, C. Schaper, T. Nielsen
Journal: Annals of Oncology (2013)
The elementary dynamics of intergroup conflict and revenge
Authors: David Pietraszewski
Journal: Behavioral and Brain Sciences (2012)

Abstract The psychology underlying revenge in an intergroup context is built around a small handful of recurrent interaction types. Analyzing the cost/benefit calculations of each agent's role within these interaction types provides a more precise way to characterize intergroup conflict and revenge. This in turn allows for more precise models of the psychology of intergroup conflict to be proposed and tested.
PROTESIS METÁLICAS AUTOEXPANDIBLES EN LA OBSTRUCCIÓN MALIGNA POR CÁNCER COLORRECTAL: REVISIÓN DE RESULTADOS Y COMPLICACIONES EN NUESTRO CENTRO
Authors: P Arbáizar, B Ferreiro, G Alcaín, M Lozano, F Martín, A Fernández, E Toscano, R Camargo, R Andrade
Journal: Endoscopy (2010)

Introducción: La obstrucción maligna del colon es considerada una emergencia quirúrgica. En los últimos años el empleo de prótesis autoexpandibles ha modificado el manejo de estos pacientes. La cirugía urgente tiene una elevada morbimortalidad (15 a 50%) y conlleva la realización de colostomía. Las prótesis metálicas autoexpandibles son una alternativa eficaz a la cirugía en pacientes con obstrucción colónica por neoplasia tanto con intención paliativa, como en los subsidiarios de tratamiento quirúrgico electivo ya que su colocación evita la realización de una colostomía urgente.
FRI0471 A comparative analysis of erosion repair in rheumatoid arthritis (RA) patients by magnetic resonance imaging (MRI) and hr-pqct
Authors: A. Regensburger, P. Koch, S. Kraus, C. Hecht, M. Englbrecht, J. Rech, G. Schett, F. Faustini, S. Finzel
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The detection of bone erosions is fundamental both for monitoring of disease activity and therapy decisions in rheumatoid arthritis (RA). Recently, it could be shown by high-resolution peripheral quantitative computed tomography (HR-pQCT) that erosion repair is associated with bone apposition at the bottom of the erosion ("sclerosis") [1;2]. MRI however is more widely available in clinical settings and used as a monitoring tool of disease activity in RA. <h3>Objectives</h3> To investigate whether MRI allows visualization of sclerosis at the bottom of erosive lesions in comparison to HR-pQCT as a reference. <h3>Methods</h3> 53 RA patients fulfilling the new ACR/EULAR criteria received a 1.5T MRI (Siemens, Vario) and an HR-pQCT (Scanco Medical AG, XtremeCT) of the metacarpophalangeal joints 2 and 3 of the clinically dominant hand. Prevalence of erosions as well as sclerosis was assessed in both imaging modalities in the coronal plane. All MRI- and CT-images were evaluated twice by two readers in a blinded fashion. Demographic and clinical data were collected for each patient. <h3>Results</h3> 69.8% of patients were females, mean ±SD age was 53.15±15.90 years; mean disease duration ±SD was 34.9±64.5 months, and mean DAS28±SD was 3.61±1.81. Prevalence of RF and ACPA was 52.8% and 58.5% respectively. A mean number of 66.5 erosions were detected by MRI per reading as compared to 81.5 erosions per reading by HR-pQCT (4 readings, 2 readers for each modality). The average proportion of correctly classified non sclerosed lesions in the MRI compared to HR-pQCT was 94% (specificity), while the average proportion of correctly classified sclerosed lesions was 31% (sensitivity). Hence, our results show a good concordance of the two imaging modalities for absence of sclerosis, but poor agreement for presence of sclerosis. On average, the observation of a "non sclerosed lesion" in the MRI was correct in 80.5% of cases after validation by HR-pQCT (negative predictive value-NPV), whereas it was 62% for "sclerosed lesions" in the MRI (positive predictive value-PPV). <h3>Conclusions</h3> According to our results, MRI has limitations to detect repair of bone lesions in RA. <h3>References</h3> Finzel S, Rech J, Schmidt S, et al. Ann Rheum Dis. 2011 Sep;70(9):1587-93. Finzel S, Rech J, Schmidt S, et al. Ann Rheum Dis. 2012 May 14. [Epub ahead of print] <h3>Disclosure of Interest</h3> None Declared
Abstract B41: Restoring sensitivity to anti-EGFR-based therapy in lung adenocarcinoma by downstream modulation of the FOXO1/KLF6 transcriptional network
Authors: Jaya Sangodkar, Suzanna Katz, Tara Albano, Heather Melville, David Burstein, Katerina Politi, Analisa Difeo, Goutham Narla
Journal: Clinical Cancer Research (2010)

Abstract Anti-EGFR-based strategies have shown clinical efficacy in the treatment of metastatic lung adenocarcinoma. Nevertheless, treatment resistance invariably develops through either de novo activation of downstream RAS/AKT signaling or acquired mutations in the Epidermal growth factor receptor (EGFR). A more thorough molecular characterization of the downstream mediators of EGFR signaling may lead to the development of newer classes of targeted molecular therapies to treat resistant disease. Here we identify a transcriptional network involving the KLF6 and FOXO1 tumor suppressor genes that regulate response to anti-EGFR-based therapies in both cell culture and in vivo models of the disease. Specifically, inhibition of AKT signaling promotes FOXO1 stabilization resulting in transactivation of the KLF6 tumor suppressor gene and induction of apoptosis in lung adenocarcinoma cell lines. Furthermore, the use of FDA-approved drug trifluoperazine hydrochloride, a FOXO1 nuclear export inhibitor restores sensitivity to erlotinib-resistant cell lines through modulation of the KLF6/FOXO1 signaling cascade in both cell culture and xenograft lung adenocarcinoma models. In addition, quantitative real-time PCR-based analysis and Western blotting confirm a significant correlation between activated oncognic EGFR signaling and downregulation of the FOXO1 and KLF6 tumor suppressor gene network in both primary human lung adenocarcinoma patient samples and a transgenic mouse model of the disease. Combined, these studies define a novel transcriptional network regulating oncogenic EGFR signaling and identify targeted molecular agents to restore chemosensitivity to anti-EGFR-based therapy in culture and in vivo. Citation Information: Clin Cancer Res 2010;16(14 Suppl):B41.
“Bearded Infant” Appearance on Bone and Ga-67 Scintigraphy in a Child with Localized Mandibular Caffey’s Disease
Authors: Sergey Bykov, Izak Garty, Ronen Spiegel, Dimitry Lumelsky, Yoseph Horovitz
Journal: Clinical Nuclear Medicine (2003)

BYKOV, SERGEY M.D.*; GARTY, IZAK M.D.*; SPIEGEL, RONEN M.D.†; LUMELSKY, DIMITRY M.D.‡; HOROVITZ, YOSEPH M.D.† Author Information
Abstract 4844: Polymorphisms in regulatory T cell related genes and ovarian cancer survival.
Authors: Bridget Charbonneau, Keith Knutson, Robert A. Vierkant, Julie M. Cunningham, Zachary C. Fogarty, Kimberly R. Kalli, Matthew J. Maurer, Ann L. Oberg, Brooke L. Fridley, Claudia C. Preston, Paul D.P. Pharoah, Susan J. Ramus, Catherine M. Phelan, Kunle Odunsi, Kirsten Moysich, Ellen L. Goode
Journal: Cancer Research (2013)

Abstract Tumor infiltrating regulatory T cells (Tregs) appear to play a role in survival in a number of solid tumors, including ovarian cancer. We assessed genetic variation via tag SNPs (N=749) in 25 Treg associated genes (CD28, CTLA4, FOXP3, IDO1, IL10, IL10RA, IL15, 1L17RA, IL23A, IL23R, IL2RA, IL6, IL6R, IL8, LGALS1, LGALS9, MAP3K8, STAT5A, STAT5B, TGFB1, TGFB2, TGFB3, TGFBR1, TGRBR2, and TGFBR3) in relation to ovarian cancer survival. SNPs were selected based on r2 ≥ 0.8, MAF ≥ 0.05, 5 kb upstream and downstream from the gene. We had SNP and outcome data for ovarian cancer from 10,084 combined ovarian cancer cases, including 5,248 high grade serous, 1,452 endometrioid, 661 mucinous, and 795 clear cell cases of European descent across multiple studies from the Ovarian Cancer Association Consortium (OCAC). Cox proportional hazards regression modeling was used to estimate per-allele hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with overall survival, adjusting for age at diagnosis, population substructure PCs, study site, histology (for the all case analysis), tumor stage, tumor grade and oral contraceptive use. The strongest associations were found for endometrioid histologic subtype and IL2RA SNPs (maximum r2=0.67) rs11256497 [HR=1.42, 95% CI: 1.22-1.64; p=5.7 x 10−6], rs791587 [HR=1.36, 95% CI: 1.17-1.57; p=6.2 x 10−5], rs2476491 [HR=1.40, 95% CI: 1.19-1.64; p=5.6 x 10−5], and rs10795763 [HR=1.35, 95% CI: 1.17-1.57; p=7.9 x 10−5], as well as clear cell ovarian cancer and CTLA4 SNP rs231775 [HR=0.67, 95% CI: 0.54-0.82; p=9.3 x 10−5]. No other associations were observed at p&amp;lt;1 x 10−4. Overall, this study provided evidence that variation in genes related to Tregs, particularly IL2RA and CTLA4, influence ovarian cancer survival. Citation Format: Bridget Charbonneau, Keith Knutson, Robert A. Vierkant, Julie M. Cunningham, Zachary C. Fogarty, Kimberly R. Kalli, Matthew J. Maurer, Ann L. Oberg, Brooke L. Fridley, Claudia C. Preston, Paul D.P. Pharoah, Susan J. Ramus, Catherine M. Phelan, Kunle Odunsi, Kirsten Moysich, Ellen L. Goode. Polymorphisms in regulatory T cell related genes and ovarian cancer survival. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4844. doi:10.1158/1538-7445.AM2013-4844
A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release
Authors: Er-Yuan Chuang, Chia-Chen Lin, Ko-Jie Chen, De-Hui Wan, Kun-Ju Lin, Yi-Cheng Ho, Po-Yen Lin, Hsing-Wen Sung
Journal: Biomaterials (2016)
Central-Nervous-System Lymphoma Related to Epstein–Barr Virus
Authors: Fred H. Hochberg, George Miller, Robert T. Schooley, Martin S. Hirsch, Paul Feorino, Werner Henle
Journal: New England Journal of Medicine (1983)

We have studied five cases suggesting a relation between Epstein-Barr virus infection and primary lymphoma of the central nervous system. A 48-year-old man had primary lymphoma of the central nervous system in the absence of systemic lymphoma or immunosuppression. Development of the tumor was associated with serologic evidence suggesting a recent primary infection with Epstein-Barr virus. DNA preparations from tumor tissue, but not from adjacent normal brain tissue, contained Epstein-Barr virus genomes when hybridized with a probe consisting of the BamHI K fragment of Epstein-Barr virus strain FF41. Evaluation of serum samples from four additional patients with central-nervous-system lymphoma revealed patterns of Epstein-Barr virus-specific antibody that were suggestive of an ongoing infection with EBV. Our results suggest induction of the lymphoma by Epstein-Barr virus.
THU0547 The Management of Patients with Chronic Pain by Primary Care Physiotherapists in the Republic of Ireland: A National Cross-Sectional Survey
Authors: C. O’Shea, B. M. Fullen
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Thirteen percent of the Irish population is affected by chronic pain (CP)<sup>1</sup>. The 2001 Primary Health Care Strategy established local primary care services, which aims to deliver 90-95% of all health and social care needs<sup>2</sup>. Chartered physiotherapists are core members of the primary care team (PCT) and frequently manage patients with chronic pain. <h3>Objectives</h3> To establish current management strategies employed by primary care physiotherapists and services available for patients with CP in the Republic of Ireland (ROI) <h3>Methods</h3> A questionnaire was distributed to all primary care physiotherapists (n=227) in the ROI. Demographic data, current assessment and management strategies utilised and level of physiotherapy-led chronic pain services available within their PCT were requested. <h3>Results</h3> Response rate was 76.1% (n=174). Three quarters of posts (77%, n=134) were senior level. Over 50% of PCPs indicated that adult CP patients comprised 41-80% of their total caseload. Only 37% (n=64) of primary care physiotherapists provide physiotherapy services other than one-to-one sessions. Of these 52% (n=33) offer group exercise classes, 22% (n=14) offer chronic pain education classes, and 8% (n=5) offer informal elements of a pain management programme. Treatment goals and discharge criteria exhibit significant disparities: limited use of outcome measures, in particular those which assess psychological well-being (24.5%) and quality of life measures (20%). Physiotherapists’ level of postgraduate education did not have a significant impact on patient management (p&gt;0.05). <h3>Conclusions</h3> Primary care physiotherapists’ assessment and management strategies do not conform to international guideline recommendations. Physiotherapy services (other than one-to-one sessions) are limited and should be expanded in line with international best practice. <h3>References</h3> Breivik, HCollett B, Ventafridda V, Cohen R, Gallacher D (2006) Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. European Journal of Pain, 10: 287-333 Department of Health and Children (2001) Primary Care: A New Direction. http://www.dohc.ie/publications/pdf/primcare.pdf <h3>Disclosure of Interest</h3> None Declared
Abstract 330: Metallothionein Preservation Of Cardiac Akt2 Signaling By Down-regulating Trb3 Prevents Diabetic Cardiomyopathy
Authors: YI TAN, Xiaoqing Yan, Shanshan Zhou, Yong Li, Yan Li, Lu Cai
Journal: Circulation Research (2014)

Cardiac insulin resistance is a key pathogenic factor for diabetic cardiomyopathy, but its mechanism remains largely unclear. Here we demonstrated that diabetes significantly inhibited cardiac Akt phosphorylation from 2 weeks to 2 months in wide-type (WT) mice, but not in cardiac-specific metallothionein-transgenic (MT-TG) mice. Cardiac Akt2 expression and phosphorylation was decreased and insulin-induced cardiac Akt2 and GSK-3β phosphorylation and glycogen synthase dephosphorylation were also decreased in WT, but not MT-TG, diabetic mice. Deletion of the Akt2 gene either in vitro H9c2 cells or in vivo significantly impaired cardiac glucose metabolic signaling. In addition, diabetes significantly increased cardiac Akt negative regulator tribbles (TRB)3 expression only in WT mice, suggesting the possible contribution of MT inhibition of diabetic up-regulation of TRB3 to Akt2 function preservation. Cardiac H9c2 cells with and without forced MT-overexpression (MT-H9c2) were treated with tert-butyl hydroperoxide (tBHP), which significantly reduced Akt2 phosphorylation in both basal and insulin-stimulating conditions only in H9c2 cells. Silencing TRB3 expression with SiRNA completely prevented tBHP’s inhibition of insulin-stimulated Akt2 phosphorylation in H9c2 cells, while overexpression of TRB3 in MT-H9c2 cells completely abolished MT preservation of insulin-stimulated Akt2 phosphorylation. Forced-overexpression of TRB3 by adenovirus-mediated gene delivery in MT-TG hearts also abolished MT’s preservation of cardiac insulin signaling and prevention of diabetic cardiomyopathy. These results suggest that diabetes-attenuated cardiac Akt2 function via up-regulating TRB3 plays a critical role in diabetic inhibition of insulin signaling in the heart. MT preserved cardiac Akt2-mediated insulin signaling by inhibiting TRB3, leading to the prevention of diabetic cardiomyopathy.
EUS elastographic pattern of normal pancreas, pancreatic neoplasm and focal pancreatitis: a preliminary study
Authors: Ping Xu, Kai Xu, Da-bin Ren, Jing Wang, Jing Yang
Journal: Endoscopy (2011)

Objective: To investigate the elastographic pattern of normal pancreas, pancreatic neoplasm and focal pancreatitis. Methods: Between January 2009 and June 2010, 6 patients (3 males and 3 females, mean age of 46.8 years) with normal pancreas and 19 patients (11 males and 8 females, mean age of 63.6 years) with focal pancreatic lesions were enrolled. The relative stiffness of tissue was described by colors superimposed on the B-mode image: hard tissue areas were marked with blue, intermediate areas with green, medium soft areas with yellow and soft areas with red. Elastographic pattern was scored with whole numbers from 1 to 5 based on the color of elastographic images: score 1 was assigned when the image showed a homogenous green area; score 2 when the image showed a mixture with green, yellow, and red; score 3 was Honeycomb like pattern with blue dominated mixed color; score 4 was assigned when the image showed a homogenous blue area and score 5 was mainly blue area mixed with areas of heterogeneous green and red. The final diagnoses were based on cytohistopathology results of EUS-FNA/surgery, or clinical follow-up of at least 6 months to exclude malignancy in the patients who did not have surgery. Results: Elastography was successfully performed in all patients and there were no procedure-related complications. Among 6 normal patients, elastographic pattern was scored as 1 in 5 patients and 2 in 1. 12 patients with focal pancreatic lesions were finally diagnosed as pancreatic carcinoma, 2 as pancreatic neuroendocrine tumor and 5 as focal pancreatitis. Elastographic pattern of pancreatic carcinoma was scored as 3 in 8 cases, 4 in 1 and 5 in 3. 2 neuroendocrine tumors were scored as 3 and 5 respectively. 5 cases of focal pancreatitis were scored as 2 in 3 cases and 3 in 2. The results indicated that normal and inflammatory tissues are relatively soft and mainly scored 1 and 2, while neoplastic lesion tends to be hard and mainly scored 3–5. When we classified score 1and 2 as benign and score 3 to 5 as malignancy, the overall diagnostic accuracy of EUS elastography for focal pancreatic lesions was 89.47% (17/19). Conclusions: There were apparent differences in elastographic pattern between benign and malignant pancreatic tissues. EUS elastography may provide a complementary method for the differentiation of benign and malignant pancreatic lesion, especially when EUS-FNA is negative or cannot be performed because of technical problems.
Perfusion Lung Scan in Lymphangitic Carcinomatosis
Authors: N Walgraeve, K Hertveldt, D Van Renterghem, A Van Den Eeckhaut, F De Geeter
Journal: Clinical Nuclear Medicine (2001)

WALGRAEVE, N. M.D.; HERTVELDT, K. M.D.; VAN RENTERGHEM, D. M.D.; VAN DEN EECKHAUT, A. M.D.; DE GEETER, F. M.D., Ph.D. Author Information
Making house calls: using telecommunications to bring health care into the home.
Authors: R Chepesiuk
Journal: Environmental Health Perspectives (1999)

According to the U.S. Federal Trade Commission, an estimated 22 million Americans used their computers to seek medical information in 1995, making health concerns the sixth most common reason for using the Internet in the United States. Market research firms estimate that the number of people going online for this purpose is growing by 70% annually. Developments in computer technology, the Internet, and wireless and satellite telecommunications have led to major innovations in the nature and delivery of health care that have broad implications for the way people will receive health information and treatment in the future, even allowing health care providers to interact through cyberspace with their patients and other caregivers.
RIGHT VENTRICULAR DYSFUNCTION IN PATIENTS WITH BREAST CANCER EXPERIENCING CARDIOTOXICITY DURING TRASTUZUMAB THERAPY
Authors: Anna Calleja, Frederic Poulin, Kiril Khorolsky, Philippe L. Bedard, Masoud Shariat, Eitan Amir, Harry Rakowski, Michael McDonald, Diego Delgado, Paaladinesh Thavendiranathan
Journal: Journal of the American College of Cardiology (2015)