tbuckley/cabot-search huggingface dataset:
1146 AGE IS THE MOST IMPORTANT RISK OF HEPATOCELLULAR CARCINOMA OF SUSTAINED VIROLOGICAL RESPONDERS TO TREATMENT FOR CHRONIC HEPATITIS C
Authors: E. Ogawa, N. Furusyo, E. Kajiwara, K. Takahashi, H. Nomura, Y. Tanabe, T. Satoh, T. Maruyama, M. Nakamuta, K. Kotoh, K. Azuma, K. Dohmen, S. Shimoda, J. Hayashi
Journal: Journal of Hepatology (2012)
Familial Hyperinsulinemia Due to a Structurally Abnormal Insulin
Authors: Masakazu Haneda, Kenneth S. Polonsky, Richard M. Bergenstal, Jonathan B. Jaspan, Steven E. Shoelson, Petra M. Blix, Shu J. Chan, Simon C. M. Kwok, William B. Wishner, Adina Zeidler, Jerrold M. Olefsky, Gary Freidenberg, Howard S. Tager, Donald F. Steiner, Arthur H. Rubenstein
Journal: New England Journal of Medicine (1984)

We have identified a patient with mild diabetes, marked fasting hyperinsulinemia (89 to 130 microU of insulin per milliliter), and a reduced fasting C-peptide: insulin molar ratio of 1.11 to 1.50 (normal, greater than 4). The patient responded normally to exogenous insulin. However, her endogenous immunoreactive insulin showed reduced biologic activity during a glucose-clamp study with hyperglycemia and a reduced ability to bind to the insulin receptor and stimulate glucose transport in vitro. Family studies showed that five additional relatives in three generations had variable degrees of glucose intolerance, marked hyperinsulinemia, and a reduced peripheral C-peptide:insulin molar ratio. Restriction-endonuclease cleavage of DNA isolated from circulating leukocytes in the patient and in family members with hyperinsulinemia revealed loss of the MboII recognition site in one allele of the insulin gene--consistent with a point mutation at position 24 or 25 in the insulin B chain. Other studies using high-pressure liquid chromatography and detailed gene analysis have identified the defect as a serine for phenylalanine substitution at position 24 of the insulin B chain. The secretion of a structurally abnormal insulin should be considered in patients with hyperinsulinemia who respond normally to exogenous insulin and have a reduced C-peptide:insulin molar ratio. Glucose tolerance may range from relatively normal to overtly diabetic.
LAYER SPECIFIC LEFT VENTRICULAR STRAIN MECHANICS WITH 2-DIMENSIONAL SPECKLE TRACKING ECHOCARDIOGRAPHY: A REFERENCE IN PATIENTS WITH NO STRUCTURAL HEART DISEASE
Authors: Rachid Abou, Melissa Leung, Martin Schalij, Nina Ajmone Marsan, Jeroen Bax, Victoria Delgado
Journal: Journal of the American College of Cardiology (2016)
Round Cell Liposarcoma Presenting as an FDG-Positive Primary With an FDG-Negative Retroperitoneal Metastasis
Authors: Rajan Rakheja, William Makis, Ayoub Nahal, Yazan Z Alabed, Gad Abikhzer, Stephan Probst, Marc Hickeson
Journal: Clinical Nuclear Medicine (2011)

A 34-year-old man, who presented with a 10-month history of an enlarging right ankle mass histologically proven to be a round cell/myxoid liposarcoma, was referred for an F-18 FDG PET/CT scan, which showed a heterogenous FDG-positive primary in the ankle and a 1.2-cm, FDG-negative, retroperitoneal lipid-attenuating nodule. On a follow-up PET/CT scan done 1 year later, the retroperitoneal nodules had grown into an 11-cm mass, which became FDG-positive and was subsequently histologically confirmed to be a liposarcoma metastasis. We present the imaging characteristics of this highly unusual case and a possible histologic explanation for the false-negative retroperitoneal metastasis on the staging PET/CT scan.
A10.05 Optimising existing tools for reaching an adequate disease control in patients with spondylarthritis
Authors: C Deaconu, D Opriş, A Peltea, D Mazilu, A Borangiu, L Groșeanu, M Negru, C Constantinescu, I Săulescu, V Bojincă, V Vlad, A Bălănescu, D Predețeanu, R Ionescu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objectives</h3> Disease activity in spondylarthritis (SpA) is widely evaluated through disease activity scores such as BASDAI, ASDAS and PtGA, with no proven superiority between them. The aim of this study was to subdivide patients with anti-TNF therapy according to their disease status indicated by scores in order to evaluate group characteristics with further assessment on the quality of each activity indicator. <h3>Materials and methods</h3> We included 100 SpA patients under anti-TNF therapy (32 infliximab, 33 adalimumab, 35 etanercept). We collected demographic, clinical (BASDAI, ASDAS, PtGA) and laboratory (ESR, CRP) data. Statistical analysis was performed with SPSS 20.0. <h3>Results</h3> We evaluated disease activity for the entire study group based on conventional scores: BASDAI, ASDAS-CRP, ASDAS-ESR, acute phase reactants and PtGA. When used as an external criterion PtGA showed that 12% of patients had active disease while 88% were classified as low disease activity (PtGA &lt;&nbsp;5). Mean ASDAS-CRP/ESR in the active group were 3.39/3.24. Mean BASDAI score in the high activity group was 5.66. We showed that both ASDAS scores had good discriminating capacities, with similar values when using the SMD (ASDAS-CRP and ASDAS-ESR – SMD 2.00). In our study group, based on PtGA, BASDAI outperformed ASDAS scores with a SMD of 3.33. We used ROC curves of the disease activity scores by using the PtGA ≥ 5 as variable of high disease activity state. For ASDAS-CRP, ASDAS-ESR and BASDAI the AUCs (<i>area under curve</i>) were 0.89 (P = 0.05), 0.88 (P &lt; 0.001), and 0.99 (P = 0.009), respectively. For CRP and ESR the AUCs were 0.81 and 0.79 (P = 0.001, P = 0.003). This shows the high accuracy of the three scores in assessing SpA activity. When dividing patients according to BASDAI score (4 as cut-off), 14% showed a more active disease than the rest of 86% who had low disease activity. Mean ASDAS scores in the first group were 3.31 and 3.16, respectively. BASDAI correlated to both ASDAS scores (r = 0.65 and 0.71, P &lt; 0.001) and PtGA stronger to BASDAI(r = 0.912, P &lt; 0.01) than ASDAS(r = 0.67 and 0.71, P &lt; 0.01). <h3>Conclusion</h3> We proved that disease activity scores have good discriminatory power and that BASDAI and ASDAS perform similarly in assessing and investigating SpA patients. BASDAI outperformed ASDAS when using PtGA as criterion.
Axillary Reverse Mapping Using 99mTc-SC
Authors: Sunny J Gandhi, C Satish, P Shanmuga Sundaram, Padma Subramanyam, D K Vijaykumar
Journal: Clinical Nuclear Medicine (2013)

Lymphedema is a common complication in breast carcinoma patients undergoing axillary lymph node dissection. Although there is a significant reduction in the lymphedema rate with sentinel lymph node biopsy compared to axillary lymph node dissection, there is some risk after sentinel lymph node biopsy. Axillary reverse mapping, an emerging concept aims at identifying and preserving the draining lymph node of the arm that is invariably devoid of malignancy. This concept if validated may prevent lymphedema in breast carcinoma patients. Axillary reverse mapping node can be identified using a radiotracer or blue dye. We describe the procedure using filtered 99mTc-SC.
Safety and clinical activity of vascular endothelial growth factor receptor (VEGFR)–tyrosine kinase inhibitors after programmed cell death 1 inhibitor treatment in patients with metastatic clear cell renal cell carcinoma
Authors: R. Nadal, A. Amin, D.M. Geynisman, M.H. Voss, M. Weinstock, J. Doyle, Z. Zhang, A. Viudez, E.R. Plimack, D.F. McDermott, R. Motzer, B. Rini, H.J. Hammers
Journal: Annals of Oncology (2016)
Meeting Report: The Third United States-Japan Meeting on the Toxicological Characterization of Environmental Chemicals
Authors: Yuji Kurokawa, Terri Damstra
Journal: Environmental Health Perspectives (1992)

The third joint meeting between scientists from the National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina, and the National Institute of Hygienic Sciences (NIHS), Tokyo, Japan, was held February 4-6,1991. The purpose of these meetings, held under the auspices of the U.S.-Japan Agreement on Cooperation in Research and Development in Science and Technology, is to exchange information on the toxicological characterization of environmental chemicals of mutual interest (1,2). The emphasis of this third meeting was on the interrelationship between toxicity, cell proliferation, and carcinogenicity and on mid-term assays and assays for initiation and promoting activities.
Book: Infections and Human Cancer: Cancer Surveys, Volume 33 Microbes and Malignancy: Infection as a cause of human cancers
Authors: D. Trichopoulos
Journal: BMJ (1999)

Eds Robert Newton, Valerie Beral, Robin A Weiss Cold Spring Harbor Laboratory Press, $93, pp 396 ISBN 0 87969 549 8 Ed Julie Parsonnet Oxford University Press, £59.50, pp 478 ISBN 0 19 510401 3 Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>, ![Graphic][4]</img>![Graphic][5]</img>![Graphic][6]</img> Few readers have avoided the unpleasant surprise of getting or, worse, buying a book with an attractive title, distinguished editors, and outstanding authors, only to find that what they have got is a collection of essays, reviews, or even research papers that were written on the occasion of a scientific meeting or without a clearly stated objective or a guiding principle. There is no such … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif [5]: /embed/inline-graphic-5.gif [6]: /embed/inline-graphic-6.gif
Late News: Healy, Broder Testify Before Natcher Subcommittee On 1992 Budget
Authors: D. A. Tisevich
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Late News: Healy, Broder Testify Before Natcher Subcommittee On 1992 Budget Get access Dorothy A. Tisevich Dorothy A. Tisevich Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 9, 1 May 1991, Page 607, https://doi.org/10.1093/jnci/83.9.607 Published: 01 May 1991
No Place to Call Home — Policies to Reduce ED Use in Medicaid
Authors: Ari B. Friedman, Brendan Saloner, Renee Y. Hsia
Journal: New England Journal of Medicine (2015)

Medicaid expansion alone may not reduce emergency-department use among new enrollees. Rather than making the ED more costly for patients to use, a promising alternative approach is to provide more robust alternatives to the ED, in keeping with the medical home model.
Panel Discussion: Role of High Risk Groups in Standard Derivation
Authors: Michael D. Utidjian, Morton Corn, Bertram Dinman, Peter F. Infante, Peggy Seminario
Journal: Environmental Health Perspectives (1979)

The recognition of high risk groups in the setting of occupational standards in the United States really appears to date from the establishment of OSHA of 1970 and the concomitant mandate for the development of criteria for Federal occupational exposure standards. Although the ACGIH recommended threshold limit values (TLV's) had been available as guidelines in increasing numbers since shortly after World War II, and these TLV's received legal endorsement by several individual states, the declared intent of the TLV's has always been to protect 'nearly   from adverse health effects. Explicit recognition is given to the Preface to the ACGIH TLV booklet each year, to the fact that 'a small percentage of workers may experience discomfort from some substances at concentrations at or below the threshold limit; a smaller percentage may be affected more seriously by aggravation of a pre-existing condition or by development of an occupational illness. The preface goes on to point out that hypersusceptibility to certain industrial chemicals (respiratory irritants, hemolytic chemicals, organic isocyanates and carbon disulfide are cited as examples) can be detected by readily available simple tests, and that such tests ''. . . may be used to screen out by appropriate job placement the hyperreactive worker...... In contrast, the philosophy behind the OSHA Standards is to protect all  from adverse health effects over a working lifetime. Recognition of the existence of hypersusceptible or high risk groups with respect to certain chemical exposures (and possibly physical agents also) must therefore impact upon the development of standards which are intended to protect  workers. Refuge in the practice of screening out of hypersusceptibles from a work force with potential exposures to any particular agent is no longer officially condoned,
PTH-025 Sniffing Disease? Optimisation of Sample Preparation for Volalite Organic Metabolomic Studies
Authors: S Reade, D Sawbridge, T Khalid, C Probert
Journal: Gut (2013)

<h3>Introduction</h3> Colitis in both humans and rodents appears to alter the metabolome. Establishing the complete mouse faecal metabolome will aid studies of change in models of disease. The optimum method for such studies had not been described; we have optimised our sample preparation and developed a quantitative method. This will allow us to develop a mouse model that could potentially be translated for diagnoses and treatment in human disease. <h3>Methods</h3> Optimisation was performed on 3, 5, 10 or 20 faecal pellets from C57BL/6 male mice (n = 4) and repeated 3 times. Volatile organic metabolite (VOM) profiles for each were analysed using SPME with a CAR/DVB/PDMS fibre and gas chromatography-mass spectrometry. This was done with careful control and monitoring of adsorption time (20 mins) and temperature (60°C) on the extraction yield during the assays. We also investigated the influence of acidification on the yield. The adsorption time of analytes in the fibre was studied testing 10, 20 and 30 minutes of extraction VOM from 10 pellets of mice faeces at 60°C. <h3>Results</h3> ANOVA found a significant difference between sample of differing size; (p &lt; 0.01); 10 and 20 pellets had most VOMs (37 and 44, respectively; NS); 10 pellets were used in later work (figure 1a). The addition of acid to faeces compared to untreated faeces produced similar chromatograms with slight increases in abundance and peak area of certain non-specific VOMs e.g. large chain organic acids (figure 1c). However, as this study aims to eventually determine disease biomarkers, at this point we do not want to influence the occurrence of specific VOMs from our samples. Varying the extraction time did not show any major differences in the quantity of VOMs identified between 10, 20 and 30 minutes, therefore our findings confirm what past literature using 20 minutes adsorption time have stated (figure 1b). <h3>Conclusion</h3> We have optimised conditions for sample preparation to produce quantifiable and significant results. We are currently performing a longitudinal experiment on 6 male and 6 female C57BL/6 mice which will result in VOM profiles for each mouse along the time course of 8 weeks of a mouse’s life, also providing us with ‘normal’ inter- and intra-animal metabolite variation. Such data will allow calibration of future studies of colonic disease in humans through the induction of colonic disease in mice. <h3>Disclosure of Interest</h3> None Declared.
Research Policy: Medical researchers: training and straining
Authors: R. Smith
Journal: BMJ (1988)

Research depends more than anything else on talented people with bright ideas.Money, equipment, and management pressure can do nothing without the talented people.This is why much of the anxiety over Britain's declining performance in science is focused on fears that bright people are becoming ever less attracted by a career in either science or research at the same time that experienced researchers are draining away abroad, particularly to the United States, and into other careers.A study conducted in 1986 by the Association ofResearchers in Medicine and Science of 200 advertisements for postdoctoral posts in medical or biological research showed that 30% of the posts were unfilled.Professor Peter Campbell, who helped conduct the survey, told me last month of a unit in a London medical school
S97 Inflammatory cytokines are elevated in patients with operable chronic thromboembolic pulmonary hypertension and predict outcome post-endarterectomy
Authors: E. Soon, A. M. Holmes, L. Barker, C. Treacy, J. Suntharalingham, M. Toshner, P. Nicklin, C. Walker, D. Budd, D. Jenkins, K. K. Sheares, J. Pepke-Zaba, N. W. Morrell
Journal: Thorax (2010)

<h3>Rationale</h3> Elevated levels of inflammatory cytokines have been reported in patients with idiopathic pulmonary arterial hypertension. The role of inflammation in chronic thromboembolic pulmonary hypertension (CTEPH) is largely unknown. We sought to establish the levels of circulating cytokines in patients with operable CTEPH and to determine if levels fall after pulmonary endarterectomy (PEA), a potentially curative therapy. <h3>Methods</h3> Forty-four patients with severe CTEPH suitable for PEA were recruited prospectively. Patients were assessed pre- and 3 months post-PEA with right heart catheterisation, 6 min walk tests and determination of serum levels of interleukins (IL)-1b, 2, 4, 5, 6, 8, 10, 12p70 and 13; TNF-α and IFNγ. Patients deemed at risk for residual CTEPH post-PEA were re-assessed invasively at a year post-PEA. Twenty-one healthy volunteers served as controls. <h3>Results</h3> CTEPH patients prior to PEA exhibited significantly raised levels of IL-1b, IL-2, IL-4, IL-8 and IL-10 compared to healthy controls. After PEA, IL-2 levels fell from 1.64 (0.83–3.34) to 1.17 (0.54–1.75) pg/ml (p=0.049), while IL-8 fell from 24.46 (13.11–38.25) to 17.44 (10.97–23.14) pg/ml (p=0.017). IL-1b and IL-4 remained elevated compared to controls. Pre-PEA levels of IL-6 and IL-8 were predictive of normalisation of PA pressures after PEA. Patients with a pre-PEA IL-6 level of &lt;7 pg/ml had a 62% cumulative probability of having a mean PAP of &lt;25 mm Hg 1 year after surgery, while patients with a pre-PEA IL-6 level of ≥7 pg/ml had a cumulative probability of 21% (p=0.01). A pre-PEA IL-6 level of ≥7 pg/ml had a specificity of 80% and a sensitivity of 59% for identifying a patient at risk of having residual PH post-PEA, with a RR of 1.7 (95% CI 1.1 to 2.6). A pre-PEA IL-8 level of ≥ 30pg/ml had a specificity of 67% and a sensitivity of 64% for identifying a patient at risk of having residual PH post-PEA, with a RR of 1.7 (95% CI 1.0 to 3.0). <h3>Conclusions</h3> CTEPH patients exhibit raised levels of cytokines, suggesting an inflammatory component to disease pathogenesis. Certain cytokines, notably IL-6 and IL-8, may be useful biomarkers to identify patients at risk for developing residual pulmonary hypertension.
MYOCARDIAL SEGMENTAL THICKNESS VARIABILITY ON ECHOCARDIOGRAPHY IS A HIGHLY SENSITIVE AND SPECIFIC MARKER TO DISTINGUISH ISCHEMIC AND NON-ISCHEMIC DILATED CARDIOMYOPATHY IN NEW ONSET CONGESTIVE HEART FAILURE
Authors: Tushar Acharya, Manmeet Singh, Kamil Muhyieddeen, David Le, Chandra Katikireddy
Journal: Journal of the American College of Cardiology (2015)
Abstract P5-07-04: Aurora kinase regulates PKC-mediated MMP-9 expression and invasion in MCF-7 breast cancer cells
Authors: JS Kim, EM Noh, YR Lee, B-M Hwang, SH Jung, HJ Youn, SJ Lee
Journal: Cancer Research (2012)

Abstract Aurora kinase is a novel family of serine/threonine kinases. Elevated expression of aurora kinase A and B is observed in many tumor cells, and dysregulation of aurora kinase has been linked to tumorigenesis. Therefore, a number of studies focused in their oncogene activities as anti-tumor targets. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM) and it is important process for breast cancer cell invasion. MMP-9 can be stimulated by activation of various cellular signaling pathways including protein kinase C (PKC), and mitogen-activated protein kinase (MAPKs), activator protein-1 (AP-1) and nuclear factor-kappaB (NF-κB) signaling pathways. Here, we show that 12-O-tetradecanoylphorbol-13-acetate (TPA), a directly PKC activator stimulation resulted in an up-regulation and phosphorlyation of aurora kinases in MCF-7 breast cancer cells. Also, Results showed that inhibition of the aurora kinases suppressed TPA-induced MMP-9 secretion/expression and cell invasion through suppression of NF-κB, AP-1, and MAPKs in MCF-7 breast cancer cell. In conclusion, this study provides new insight into the novel role of aurora kinase for expression of MMP-9 by TPA and regulation of aurora kinase by TPA through MAPKs signaling pathway. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P5-07-04.
AB0809 Teriparatide – Better Efficacy in Primary Osteoporosis and Lower T-Score
Authors: J. Abelha-Aleixo, R. Fonseca, D. Gonçalves, R. Vieira, G. Terroso, P. Madureira, A. Bernardo, M. Bernardes, L. Costa
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Teriparatide is an anabolic agent that has been shown to increase bone mineral density (BMD) and reduce the risk of fracture. Despite its unique mechanism, there are still few reviews respecting any differences on treatment efficacy in the different types of osteoporosis. <h3>Objectives</h3> To evaluate if there are differences between primary (OP1) and secondary (OP2) osteoporosis (glucocorticoid-induced osteoporosis and/or secondary to chronic inflammatory diseases), and the several initial indications for treatment, concerning the markers of bone turnover (MBT) and bone mineral density changes, on patients under teriparatide treatment. <h3>Methods</h3> All patients treated with teriparatide for osteoporosis at our centre were retrospectively evaluated. The indications for treatment were listed as: lumbar spine T-score ≤-4 (13 patients); lumbar spine T-score ≤-3 and presence of radiographic vertebral fractures (32 patients); and others (18 patients). BMD values at baseline and 18 months were obtained by DEXA with a LUNAR Expert 1320. The MBT measured at baseline, 3 and 18 months were: β-C-telopeptide of collagen 1 crosslinks, osteocalcin, alkaline phosphatase and 25(OH) vitamin D3. MBT and BMD variations between baseline and 18 months were tested according to the presence of OP1 or OP2, and indications for treatment, using non-parametric tests (SPSS 21.0 for statistical data analysis). <h3>Results</h3> Sixty three patients were evaluated (58 women), 25 (39,7%) with OP1, and 38 (60,3%) with OP2. Comparing to OP2, OP1 was significantly associated (p&lt;0,050) with higher gains of BMD at Wards triangle (5,5% vs 1,3%), total hip (3,5% vs 0,3%) and lumbar spine (21,65% vs 9,9%). There were no differences concerning MBT in OP1 vs OP2. Regarding the several treatment indications, there were no differences in terms of MBT. Concerning BMD variations, the group with lumbar spine T-score &lt;-4 was the only that showed higher gains in bone mass, namely at the lumbar spine BMD (22,8% vs 8,9% g/cm<sup>2</sup>). <h3>Conclusions</h3> OP1 seems to have better response than OP2 to teriparatide treatment at total hip, lumbar spine and Wards triangle in terms of BMD gains. The indication for treatment does not appear to influence the results, both in terms of BMD gains and MBT changes, with the exception of those patients with lumbar spine T-score&lt;-4, who exhibited greater gains at lumbar spine BMD. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4267