tbuckley/cabot-search huggingface dataset:
AB0587 The Outcomes of Systemic Lupus Erythematosus Triggered in Children and Adolescents
Authors: L. Mazur, V. Sadovici, M. Cebanu, N. Revenco, M. Mazur
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic Lupus Erythematosus is a disease that affects primary women in childbearing period, in 10-20% of cases the disease begins in childhood and adolescence. Although clinical symptoms and laboratory test results in patients with childhood onset are similar to those seen in adult onset lupus, patients with pediatric systemic lupus erythematosus (pSLE) tend to have a higher rate of of organ involvement that impact the clinical prognosis. <h3>Objectives</h3> To estimate the particularities of pSLE9s evolution. <h3>Methods</h3> We performed a retrospective study including patients with adult and pediatric onset of SLE, which fulfill ACR 1997 classification criteria. The disease activity was determined by SLEDAI and the damage – by SLICC DI. <h3>Results</h3> It was performed a retrospective study including 90 adults patients with SLE, 13 patients of them, developed lupus at the age of 15.5±1.9 (iv 7-18) years with a disease duration of 13.1±4.4 years (iv-328 14 months), the ratio of males: females 10:1. The disease activity was evaluated by SLE activity index (SLEDAI), which is an important measurement for guiding therapy and the cumulative activity of the disease, which over time proved to be an important predictor of the evolution o f thdisease. The average activity at onset in pLES was 21,18±4.6 points, while in adults 17.3±6.4 points. The SLICC damage index in pSLE was estimated at 0 points while at the time of the study there were 2 points (through osteoporosis, pathological fractures, aseptic necrosis and hemodialysis). At the onset of pSLE, where were 5 cases of nephritis, vascular damage-3 cases, skin involvment -10, impaired joint-7 cases. Antiphospholipid syndrome was determined in 5 patients (38.5%). Among 13 pSLE patients, 3 died: one patient after 1 year of diagnosis and 2 patients after 5 years from the onset. The death was caused by progressive renal impairment in 2 cases and complications of antiphospholipid syndrome (thromboses)-one case. The 17 patient9s9 pregnancies were monitored and their consequences: 2-medical abortions, 6- miscarriages, 2 dead fetus and seven healthy children were born by 6 LESp women. <h3>Conclusions</h3> The pediatric lupus was noted by aggressive clinical evolution and high activity at the onset. The SLICC DI during the evolution of the disease was determined in particular by impairment of bone tissue and antiphospholipid syndrome was detected in 38.5% cases, in correlation with mortality rate (r-0.83, p&lt;0,05). <h3>Disclosure of Interest</h3> None declared
SAT0455 Subclinical Atherosclerosis and Estimation of Cardiovascular Risk in Systemic Sclerosis
Authors: G. Ozen, F. Korkmaz, M. Sunbul, R. Deniz, K. Tigen, P. Atagunduz, N. Inanc, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> During the last decade, it has been shown that cardiovascular disease (CVD) in systemic sclerosis (SSc) is increased and accounts for ∼30% of the SSc mortality. But, whether this is due to accelerated atherosclerosis and how to detect patients with high risk are still unclear. <h3>Objectives</h3> To determine the frequency of subclinical atherosclerosis in patients with SSc compared to rheumatoid arthritis (RA) and to determine the ability of CV risk indices in detecting high risk SSc patients. <h3>Methods</h3> Eighty one SSc patients (F/M=74/7; age 49.7±12.1 years, limited/diffuse=49/32) and 80 age-sex matched RA patients (F/M=73/7;age 50.1±10.5 years) without CVD were assessed. All patients were evaluated with carotid ultrasonography (US). Carotid intima-media thickness (cIMT) &gt;0.90 mm and/or carotid plaques were used as the gold standard test for subclinical atherosclerosis and high CV risk (US+). Systematic Coronary Risk Evaluation (SCORE), QRisk II and 2013 American College of Cardiology/American Heart Association (ACC/AHA) 10-year atherosclerotic CV disease risk (ASCVD) indices were calculated. <h3>Results</h3> Fifteen (18.5%) SSc and 19 (23.8%) RA patients had subclinical atherosclerosis (<i>P</i>=0.41). The mean cIMT (mm) was also similar in both groups (0.67±0.15 vs 0.68±0.15, <i>P</i>=0.74). None of the CV risk factors in SSc patients were worse than RA patients except for lower HDL-chol levels (table 1),but total-chol/HDL-chol was similar (3.6±0.9 vs 3.5±1). When US+ and US- SSc patients were compared, it was observed that US+ SSc patients were older, had more pulmonary arterial hypertension (PAH), elevated ESR, HT and less immunsuppressive usage (Table 2). In multivariate analysis, age (OR=1.1, 95% CI [1.02-1.8], <i>P</i>=0.014), elevated ESR (OR=9.3, 95% CI [1.6-55.5], <i>P</i>=0.014) and PAH (OR=4.8, 95% CI [1.12-20.8], <i>P</i>=0.035) were independently associated with subclinical atherosclerosis. Concerning CVD risk indices, of the 15 US+ patients only 0, 1 (6.7%) and 3 (20%) patients were classified as high CV risk according to SCORE, QRisk II and ACC/AHA 10-year ASCVD risk, respectively. <h3>Conclusions</h3> Subclinical atherosclerosis in SSc is as frequent as in RA in which accelarated atherosclerosis is clearly defined. Atherosclerosis in SSc is independently associated with age, elevated ESR and PAH. CV risk indices, SCORE, QRisk II and ACC/AHA 10-year ASCVD risk are considerably insufficient in SSc to detect patients with subclinical atherosclerosis. <h3>Disclosure of Interest</h3> None declared
Identifying the depressive border of the borderline personality disorder
Authors: S Snyder, C Sajadi, W M Pitts, W A Goodpaster
Journal: American Journal of Psychiatry (1982)

The relationship between depression and borderline disorder is unclear. Using standardized observer- and subject-rated scales for depression, the authors compared patients satisfying DSM-III criteria for borderline personality disorder and dysthymic disorder. The two groups did not differ on depression as defined by the scales; however, there was a substantial intergroup difference on certain characteristics of the depression spectrum thought empirically to be associated more often with the borderline patient. The depth and quality of the depression of the borderline patient may largely overlap with that of the dysthymic patient, but it also possesses features that make it qualitatively distinct.
P-069 Risk Factors of Submucosal or Lymphovascular Metastasis during resection of the Early Gastric Cancer by Endoscopic Submucosal Dissection
Authors: J.G. Shin, J.H. Jeon, W.C. Kim, D.H. Kang, H.W. Kim, C.W. Choi, S.B. Park, S.J. Kim, H.S. Nam
Journal: Annals of Oncology (2015)
Radiotherapy still has a major role in the management of localized orbital rhabdomyosarcoma.
Authors: J E Kingston, P N Plowman, J Wright
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.3.798 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7884442 Radiotherapy still has a major role in the management of localized orbital rhabdomyosarcoma. J E KingstonxJ E KingstonSearch for articles by this author , P N PlowmanxP N PlowmanSearch for articles by this author , J WrightxJ WrightSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.3.798 PDF "Radiotherapy still has a major role in the management of localized orbital rhabdomyosarcoma.." Journal of Clinical Oncology, 13(3), pp. 798–799© 1995 by American Society of Clinical Oncology
Case 43-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Jack D. Myers, Eugene J. Mark
Journal: New England Journal of Medicine (1980)

Presentation of CaseA 27-year-old woman was admitted to the hospital because of dyspnea.She was well until five weeks earlier, when she began to have pain in the left flank, hip, and thigh. Two weeks before admission progressive dyspnea and a dry cough developed. Two days before entry she was admitted to another hospital, where examination revealed a dyspneic, cyanotic woman with a blood pressure of 110/75 mm Hg. The jugular veins filled just above the level of the clavicle at 30° of elevation. The lungs were clear. The heart was not enlarged; a right ventricular lift was present; . . .
AB0404 Impact of Methotrexate in Mono- and Combined with Biologic Agents Therapy on Metabolic Syndrome Components in Early Rheumatoid Arthritis Patients: Table 1
Authors: Y. Gorbunova, T. Popkova, L. Kondratyeva, D. Novikova, E. Luchikhina, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Metabolic syndrome (MeS) is a combination of cardiovascular complications risk factors (obesity, hyperglicemia, increasd triglycerides levels, dicreased HDL cholesterol levels,arterial hypertension), diagnosed in 19-55% rheumatoid arthritis (RA) pts. <h3>Objectives</h3> To evaluate the impact of MT in mono- and combined with biologic agents therapy on MeS components in early RA pts after 24 weeks of treatment. <h3>Methods</h3> Included 74 pts (54f/20m) with early RA (ACR/EULAR 2010 criteria), without prior therapy with GCs and DMARDs. Median age 56 [46;61] y, duration of the disease 6 [4,0;8,0] months, RF positive (87%), ACCP positive (100%); high RA activity (DAS28 5,6 [5,1;6,4]). The following MeS components (NCEP/ATP III)were evaluated at baseline and after 24 weeks of therapy: WC≥102 cm (m)/≥88 cm (f), blood pressure ≥130/85 mmHg, hypertriglyceridemia - increased level of TG≥1,7 mmol/l, decerased HDL cholesterol level &lt;1,0 mmol/l (m)/&lt;1,3mmol/l (f), increased fasting glucose level ≥6,1 mmol/l. MeS was diagnosed in pts having ≥3 symptoms. All pts were administered subcutaneous methotrexate (SC MT)with dose escalation to 25-30 mg/week, in pts with poor response additional biologic agents therapy was administered in 12 weeks after initiation of SC MT (24pts - adalimumab; 9 - certolizumab pegol; 6 - abatacept; 1 - tocilizumab). <h3>Results</h3> MeS prevalence in early RA pts prior to DMARDs intiation was 30%. Based on therapeutic regimens pts were grouped in two groups: I - MT monotherapy (n=34); II - combined therapy MT + biologic agents (n=40). Rates of decresaed HDL cholesterol levels were significantly higher at baseline in poor responders to MT monotherapy pts, requiring administration of biologic therapy, as compaired to pts with good response to MT therapy. After 24 weeks of therapy both groups demostrated improvement in HDL cholesterol levels and hypertriglyceridemia, more pronounced in MT therapy group. Dynamics in AO and hyperglycemia showed different trends: group I demonstrated decline in the rates of AO and hyperglycemia; group II - escalation in the rates of AO and hyperglycemia (p&lt;0,05). Comparable decrease in MeS rates was observed in both groups. Rate of remissions (DAS28&lt;2,6) by week 24 in group I was 47%, in group II -22,5% (p&lt;0,05). <h3>Conclusions</h3> In early RA pts rates of MeS decreased following the decline in disease activity after 24 weeks of "Treat to Target". In MT monotherapy group rates of all MeS components went down,except for eleated BP. Combined MT+ biologic,despite decreasing MeS rates, is associated with growing rates of AO and hyperglycemia, probaly due to short term treatment and lower precentage of pts achieving remission by 6 months of therapy. <h3>Disclosure of Interest</h3> None declared
Proteasome Addiction Defined in Ewing Sarcoma Is Effectively Targeted by a Novel Class of 19S Proteasome Inhibitors
Authors: Neerav Shukla, Romel Somwar, Roger S. Smith, Sri Ambati, Stanley Munoz, Melinda Merchant, Padraig D'Arcy, Xin Wang, Rachel Kobos, Christophe Antczak, Bhavneet Bhinder, David Shum, Constantin Radu, Guangbin Yang, Barry S. Taylor, Charlotte K.Y. Ng, Britta Weigelt, Inna Khodos, Elisa de Stanchina, Jorge S. Reis-Filho, Ouathek Ouerfelli, Stig Linder, Hakim Djaballah, Marc Ladanyi
Journal: Cancer Research (2016)

Ewing sarcoma is a primitive round cell sarcoma with a peak incidence in adolescence that is driven by a chimeric oncogene created from the fusion of the EWSR1 gene with a member of the ETS family of genes. Patients with metastatic and recurrent disease have dismal outcomes and need better therapeutic options. We screened a library of 309,989 chemical compounds for growth inhibition of Ewing sarcoma cells to provide the basis for the development of novel therapies and to discover vulnerable pathways that might broaden our understanding of the pathobiology of this aggressive sarcoma. This screening campaign identified a class of benzyl-4-piperidone compounds that selectively inhibit the growth of Ewing sarcoma cell lines by inducing apoptosis. These agents disrupt 19S proteasome function through inhibition of the deubiquitinating enzymes USP14 and UCHL5. Functional genomic data from a genome-wide shRNA screen in Ewing sarcoma cells also identified the proteasome as a node of vulnerability in Ewing sarcoma cells, providing orthologous confirmation of the chemical screen findings. Furthermore, shRNA-mediated silencing of USP14 or UCHL5 in Ewing sarcoma cells produced significant growth inhibition. Finally, treatment of a xenograft mouse model of Ewing sarcoma with VLX1570, a benzyl-4-piperidone compound derivative currently in clinical trials for relapsed multiple myeloma, significantly inhibited in vivo tumor growth. Overall, our results offer a preclinical proof of concept for the use of 19S proteasome inhibitors as a novel therapeutic strategy for Ewing sarcoma. Cancer Res; 76(15); 4525-34. ©2016 AACR.
AB0334 Cardiac Echocardiography Findings of Patients with Rheumatoid Arthritis:
Authors: A. Yazici, F. Cosan, B. Yilmazer, A. Cefle
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic inflammatory disease which is found to cause the risk of cardiovascular diseases (1,2). <h3>Objectives</h3> In the present study, we aim to identify changes that are present in Echocardiograms of patients with RA. <h3>Methods</h3> By analyzing the records of follow-up patients with RA in the clinics of Rheumatology in Kocaeli Faculty of Medicine, 200 patients with Echocardiograms (Male/ Female: 155/45, age range: 57.12±12.08 year, average duration of disease: 108.57±115.99 month) were examined. Results of Echocardiography were analyzed with regard to systolic and diastolic functions, problems with valves, and internal chamber size quantification. <h3>Results</h3> It was found that of all patients 67.2% had positive RF and %58.4 had positive antiCCP, and 40% (80) of patients had other accompanying diseases. Of these 35.5% (71) had hypertension; 5% (10) had ischemic heart disease, and 14.1% (28) had diabetes. When the findings of Echocardiography were examined, 12 patients (6%) were diagnosed with systolic dysfunction, 9 (4.5%) patients were diagnosed with pericardial infusion, 17 (8.5%) patients were diagnosed with valvular dysfunction, and 128 (68.1%) patients were diagnosed with diastolic dysfunction. There was spontaneous echo contrast (SEC) in 2 patients with heart valve prosthesis. 41 (20,5%) patients had pulmonary hypertension, and 184 (92%) had valve regurgitation, and only 14% of patients had medium and serious regurgitations (17 patients with mitral regurgitation, 15 patients with tricuspid, 10 patients with aortic and only 1 patient with pulmonary valve were identified). When left ventricular mass is calculated, 131 (65.5%) patients had an increase in hypertrophy; 33.5% of patients were affected by hypertrophy in left atrium and 11% in the right ventricular area. When findings were compared by taking accompanying diseases, sex and age (57.5% were above 55) into consideration, increase in left ventricular mass, left atrium hypertrophy and diastolic dysfunction were observed in patients over 55 age with accompanying diseases and pulmonary hypertension was identified more frequently in patients over 55 age. <h3>Conclusions</h3> Due to increase in the risk of cardiovascular disease and accompanying other diseases various Echocardiography findings can be identified in many patients. <h3>References</h3> van Breukelen-van der Stoep DF, Klop B, van Zeben D, Hazes JM, Castro Cabezas M.Cardiovascular risk in rheumatoid arthritis: how to lower the risk? Atherosclerosis. 2013 Nov;231(1):163-72. doi: 10.1016/j.atherosclerosis.2013.09.006 Barbhaiya M, Solomon DHRheumatoid arthritis and cardiovascular disease: an update on treatment issues. Curr Opin Rheumatol. 2013 May;25(3):317-24. <h3>Disclosure of Interest</h3> None declared
Perceived personal networks as mediators of stress reactions
Authors: P Steinglass, E Weisstub, A K De-Nour
Journal: American Journal of Psychiatry (1988)

The evacuation of an Israeli community in the Sinai peninsula afforded an unusual opportunity to study the longitudinal relationships between personal network characteristics and psychosocial adjustment. Friendship network characteristics proved highly stable longitudinally but were poor predictors of long-term adjustment. The kinship network characteristics before relocation were better predictors, despite the fact that kin were not actually present in the community before relocation. These data support a hypothesis that the perception of social embeddedness rather than the actual availability of social supports mediates reactions to stressful life events.
AB1187 Role of Intangible Costs in the Economic Burden of Systemic Lupus Erythematosus
Authors: V. Sadovici, M. Cebanu, L. Mazur-Nicorici, V. Salaru, S. Vertrila, M. Mazur
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic, disabling, progressive disease, with many associated comorbidities, affecting patients during prime working years resulting in a high economic burden on society, producing high direct, indirect and intangible costs [1]. Pain and sufferings of patients because of a disease, which are usually measured by using the reduction in Quality of Life (QoL), define intangible costs. To date, there is <i>no data available</i> about intangible costs of SLE in the Republic of Moldova. <h3>Objectives</h3> To estimate the intangible costs of SLE in the Republic of Moldova. <h3>Methods</h3> We conducted a cross-sectional study including consecutive patients fulfilling the SLICC, 2012 classification criteria for SLE. The disease activity was calculated by SLAM and damage index - SLICC/ACR DI. The intangible costs were calculated using two methods: willingness-to-pay (WTP) for a hypothetical cure of SLE and QoL, estimated by SF-8 questionnaire. <h3>Results</h3> The study included 106 patients, female:male ratio 10,7:1, mean age ± SD of41,1±12,6 yr, mean disease duration ± SD 90,0±87,2 months. The disease activity by SLAM was 11±5,2 points and mean SLICC/ACRDI 1,9±2,4 points. The analysis of the mental and physical component status of the QoL showed a reduction of both variables compared to general population: PCS and MCS were 43,2±9,6 and 46,9±13,4 points, respectively. It was established a close significant negative correlation between physical component status and disease activity by SLAM (r=-0,83, p&lt;0,001) and no correlation with variables as disease duration, age at onset, socio-economic status. The monetary value of intangible costs was characterized by a large distribution, ranging from 790 to 52,600 thousands Euros, with a mean value of 9,420 Euros. The monetary value of intangible costs was influenced by the disease activity and working status (p&lt;0,05). <h3>Conclusions</h3> The intangible costs are an important component of SLE9s total costs, influencing substantially the disease9s economic burden in Republic of Moldova. <h3>References</h3> Turchetti G et al. Systemic lupus erythematosus and the economic perspective: a systematic literature review and points to consider. Clin Exp Rheumatol. 2012 Jul-Aug;30 (4 Suppl 73):S116-22. Epub 2012 Oct 16. <h3>Disclosure of Interest</h3> None declared
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Authors: Matjaz Rokavec, Meryem Gülfem Öner, Huihui Li, Rene Jackstadt, Longchang Jiang, Dmitri Lodygin, Markus Kaller, David Horst, Paul K. Ziegler, Sarah Schwitalla, Julia Slotta-Huspenina, Franz G. Bader, Florian R. Greten, Heiko Hermeking
Journal: Journal of Clinical Investigation (2015)
The psychiatric use of electrically induced seizures
Authors: R D Weiner
Journal: American Journal of Psychiatry (1979)

ECT is an effective but also controversial treatment modality in psychiatry. The decision of when to use ECT is predicated on a knowledgeable assessment of anticipated benefits and possible risks as they apply to each individual case. Refinements in ECT technique have minimized risks, but have also increased the methodological complexity. The author presents a clinical review of ECT use with particular emphasis on practical issues related to efficacy, risks, and technique.
Improvement of the Automatic Endoscopic Reprocessor: Self-Cleaning Disinfecting Connectors Between Endoscope and Reprocessor
Authors: Y.  Ishino, K.  Ido, K.  Sugano
Journal: Endoscopy (2003)

We have previously pointed out a defect of automatic endoscopic reprocessors, i. e. the contamination of the connecting part between the endoscope and the reprocessor. We evaluated a newly designed connector (MH-861; Olympus, Tokyo, Japan) with a self-cleaning and disinfection mechanism, which enabled cleaning and disinfection of both the connector itself and its interface with the suction and air/water valves during a reprocessing cycle, which was not previously possible.Ten upper gastrointestinal endscopes were examined in the study. Swabs were taken from the suction and air/water valves for microbiological culture before and after reprocessing by the washer-disinfector. The numbers of contaminated endoscopes before and after reprocessing with the new connector were compared.Before the procedure there were five contaminated endoscopes and none after the procedure. When the new connector was used, the difference in cleaning and disinfection of the connecting parts was significant (P = 0.0325).We conclude that the newly developed connector permits effective cleaning and disinfection by automatic reprocessors.
A Multifaceted Mandatory Patient Safety Program and Seasonal Influenza Vaccination of Health Care Workers in Community Hospitals
Authors: Edward J Septimus, Jonathan B Perlin, Scott B Cormier, Julia A Moody, Jason D Hickok
Journal: JAMA (2011)

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