AB0635 Clinical and Autoantibodies Features in Autoimmune/Inflammatory Syndrome Induced by Adjuvants: Mineral Oils and Silicone
Authors: O.L. Vera-Lastra, M. Satoh, C.V. Martinez-Macias, J. Sepúlveda, M. Vazquez del Mercado, R. Vargas-Ramirez, B.T. Martin-Marquez, J. Calise, L.J. Jara-Quezada
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Autoimmune/Inflammatory Syndrome Induced by Adjuvants (ASIA) is associated with adjuvants such as: squalene, aluminum, silicone and injections of mineral oil (MO). <h3>Objectives</h3> We aimed clinical and autoantibodies features in patients with ASIA induced by injection of MO used with cosmetic purposes and silicone breast implants (SBI). <h3>Methods</h3> 29 women patients with injection of MO, other substances (methacrylate, silicone fluid, guaiacol) and SBI that developed clinical manifestations of defined autoimmune rheumatic disease (ARD) or non-specific manifestation of autoimmune rheumatic disease (NSARD) were included. Antinuclear antibodies (ANA) were done in all patients by immnofluorescense (HEp-2 slide). Autoantibody profile was done by immunoprecipitation and by ELISA (anti-dsDNA, beta2 glycoprotein I, anti-Ro 52 and anti-U1RNP-70kD) <h3>Results</h3> Mean age (47±10) years, 22 patients were injected with MO (in 5 patients the MO were combined with other substances: collagen, guaiacol, silicone liquid), 2 with methacrylate, 1 with mercury and 4 had SBI. The clinical manifestations were: chronic fatigue 82%, skin lesion 76%, arthralgias 68%, myalgias 62%, sleep disturbances 62%, fever 62%, arthritis 45%, cognitive disturbances 34%, weakness 34%, xerostomy 18%, gastrointestinal disturbances 14%, respiratory disturbances 7% and myopathy 7%. The main diagnosis were: NSARD: 59%, ARD 41%: panniculitis, thyroiditis, systemic sclerosis (SSc), Still disease, SLE, dermatomyositis, angiomatosis, hemolytic anemia. All patients with SBI met criteria for SSc, SLE and Still9s disease. ANA were present in 66% of patients, being the most common pattern nuclear and nucleolar (26% each) followed by mithocondrial-like 16%, cytoplasmic dots, centromere (11% each), cytoplasmic dots and DFS70-like in 5% each. Anti-U1RNP and anti-Su/Argonaute in 2 (SLE and NSARD) were found in 7% (2/29) each, anti-Ro 52kD and anti-Ro 60kD were in 10% each (3/29). Two cases of anti-centromere were also positive by anti-CENP-B ELISA 7%. Anti-β2GP1 was in one case 3%. <h3>Conclusions</h3> This study demonstrated the induction of ASIA after injection of MO and SBI. For first time we reporting patients injected with MO in whom the immunologic response with anti-Su antibodies production is very similar to observed in nonautoimmune strains of mice exposed to pristane, a component of MO. The induction of ASIA after MO and SBI exposition may be relevant to understanding the mechanism and origen of autoantibodies and the pathogenesis of ARD. <h3>References</h3> Vera-Lastra O, Medina G, Cruz-Dominguez Mdel P, Jara LJ, Shoenfeld Y. Autoimmune/inflammatory syndrome induced by adjuvants (Shoenfeld9s syndrome): clinical and immunological spectrum. Expert Rev Clin Immunol. 2013(4):361-73. Vera-Lastra O, Medina G, Cruz-Dominguez Mdel P, Ramirez P, Gayosso-Rivera JA, Anduaga-Dominguez H, Lievana-Torres C, Jara LJ. Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld9s syndrome). Lupus. 2012;21(2):128-35 <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4861