tbuckley/cabot-search huggingface dataset:
SAT0507 Detection of Novel Cerebral Microvessel Lesions in Patients with Neuropsychiatric Systemic Lupus Erythematosus by 7Tesla MRI
Authors: N. Sasaki, O. Murata, Y. Ninomiya, Y. Hosoya, N. Suzuki, R. Koizumi, Y. Nakamura, H. Kobayashi, K. Yamauchi, M. Sasaki
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The cerebral microvascular lesions of patients with neuropsychiatric systemic lupus erythematosus (NPSLE) have not been fully elucidated. The 7Tesla MR scanner has <b>high image resolution</b> and can be expected to detect cerebral <b>microvascular lesions</b> that have never before been visible. <h3>Objectives</h3> We examined the cerebral microvascular lesions of NPSLE using a 7Tesla MR scanner. <h3>Methods</h3> We studied 15 patient (5 NPSLE (three, acute phase; two, past history); 10, non-NPSLE). MRI was performed using a 1.5Tesla MR scanner and 7Tesla MR scanner (T1-weighted imaging(T1WI), T2-weighted imaging(T2WI), diffusion-weighted imaging(DWI), magnetic resonance angiography). Two radiologists performed the interpretation without clinical information. Diagnosis of NPSLE was determined by a neurologist, psychiatrist and rheumatologist. <h3>Results</h3> Examination by the 7Tesla MRI revealed cerebral microvascular lesions in four of five NPSLE patients (acute phase, three; past history, one). These findings were not detected in any of the patients with non-NP SLE. The cerebral microvascular lesions were found around the central sulcus especially in T2WI. These MRI findings disappeared after central nervous symptom improvement in two of the three acute phase patients. However, we did not find a direct association between the MRI findings and the neuropsychology dysfunction. Image:41 years old female She had both legs motor nerve disorder. The cerebral microvascular lesions were found around the central sulcus in T2WI and DWI. It could be find only by using 7TeslaMRI. <h3>Image/graph</h3> <h3>Conclusions</h3> Cerebral microvascular lesions could be detected in patients with NPSLE by 7 Tesla MRI, suggesting that 7 Tesla MRI is a useful tool for diagnosing the cerebral lesions of NPSLE. It will be necessary to elucidate the association between cerebral microvascular lesions and neuropsychological dysfunction. <h3>Disclosure of Interest</h3> None Declared
TCTAP A-181 Predictors of Recurrent Chest Pain in Vasospastic Angina Patients from 3-year Clinical Outcome Data
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Abstract 5208: Overexpression of EZH2 increases multipotent mammary stem cell self-renewal and differentiation
Authors: Xin Li, Katherine Toy, Celina G. Kleer
Journal: Cancer Research (2012)

Abstract BACKGROUND: A role for EZH2 in stem cell maintenance was recently reported. Our lab has previously demonstrated that overexpression of EZH2 accelerates the initiation of ErbB2-induced mammary tumors. To understand underlying mechanism, we investigated the role of EZH2 in regulation of stem cells and luminal progenitor cells utilizing xenotransplantation studies of preneoplastic mammary glands of EZH2+; neu and EZH2 wt; neu transgenic mice. METHODS: Generation of crossing EZH2+; neu and EZH2 wt; neu transgenic mice was described previously. Mouse handling and experimental procedures were conducted in accordance with the NIH Guide for the Care and Use of Laboratory Animals and were approved by the IACUC of the UM. Stem cells (Lin-/CD49f+/ESA-) and luminal progenitor cells (Lin-/CD49f+/ESA+) were isolated from the hyperplastic mammary glands of 8 weeks old EZH2+; neu and EZH2 wt; neu mice by flow cytometry (n=15 per group). Stem cells and luminal progenitor cells were injected into cleared fat pads of 3 weeks old FVB mice. After 5 weeks the mammary glands were subjected to flow cytometry and histology. RESULTS: Histologic study showed that only the stem cells, but not the luminal progenitor cells, extracted from EZH2+; neu and EZH2 wt; neu transgenic mice were able to form mammary outgrowths. Outgrowths of EZH2+;neu mice had significantly increased epithelial proliferation and increased numbers of terminal end buds (p&amp;lt;0.05) compared to EZH2 wt;neu outgrowths. EZH2 +;neu outgrowths had significant upregulation of Ki67 and pSTAT5 proteins. Flow cytometry of the outgrowths revealed that while all cell populations were increased, EZH2 induced a more pronounced expansion of the stem cell and luminal progenitor cell populations. CONCLUSIONS: Our data show that EZH2 overexpression in ErbB2 mice induces an expansion of the multipotent mammary stem cell population with the ability to regenerate the cellular heterogeneity of the mammary gland and develop hyperplastic outgrowths. We found that EZH2 promotes hyperproliferation and upregulation of STAT5 phosphorylation in the mammary epithelium in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5208. doi:1538-7445.AM2012-5208
EVALUATION OF MYOCARDIAL BLOOD FLOW AND CORONARY FLOW RESERVE AFTER IMPLANTATION OF A BIORESORBABLE VASCULAR SCAFFOLD VERSUS METAL DRUG ELUTING STENT: AN INTERIM 1-MONTH ANALYSIS OF THE VANISH-TRIAL
Authors: Wijnand Stuijfzand, Pieter Raijmakers, Roel S. Driessen, Adriaan Lammertsma, Albert van Rossum, Alexander Nap, Yolande Appelman, Jorrit Lemkes, Maarten Van Leeuwen, Niels Van Royen, Paul Knaapen
Journal: Journal of the American College of Cardiology (2016)
AB1030 Phospho-calcium metabolism in patients with hip fracture
Authors: M. Aparicio, I. Martin-Esteve, P. Estrada, A. Montero, A. Coscujuela, C. Gomez-Vaquero
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In Spanish population, there is a high prevalence of hypovitaminosis D which is more severe in elderly patients and, above all, in patients with hip fracture. <h3>Objectives</h3> Study the analytical parameters of phospho-calcium metabolism in patients with hip fracture, with special emphasis on the serum concentration of calcidiol and on response to supplements of calcium and vitamin D. <h3>Methods</h3> Prospective cross-sectional study including individuals admitted for hip fracture to a university hospital in the period between March 1, 2009 and December 31, 2010. Pathological or secondary to high impact trauma fractures, and patients with a glomerular filtrate &lt;30 ml/min were excluded (n: 101).All patients were interviewed and variables were systematically introduced into a database. Socio-demographic, clinical and analytical data related to the status of the patient prior to fracture, complications arising during admission and follow-up were collected at 3 months and a year. The following analytical parameters of phospho-calcium metabolism were identified in peripheral blood: corrected calcium, phosphate, total alkaline phosphatase (FFAA), calcidiol, and parathormone (PTH). Seventy-eight (24%) patients were receiving supplements of calcium and vitamin D. Deficiency of vitamin D was defined as the serum concentration of calcidiol &lt;25 nM/L andinsufficiencyas &lt;50 nM/L. <h3>Results</h3> We included 324 patients (83±8 years, 71% women). The analytical parameters are shown in the table below. 58% of patients had vitamin D deficiency. The monthly distribution of the average concentrations of calcidiol showed a statistically significant increase in the summer months. Patients receiving calcium and vitamin D supplements had a higher mean serum concentration of calcidiol (47.6±43.4 nM/L vs 25.2±11.2 nM/L; p&lt;0.001), a lower vitamin D deficiency (24% vs. 60%; p&lt;0.001) and insufficiency (71% vs 96%; p&lt;0.001) than those who did not receive them. The rest of analytical parameters were not different between the two groups. <h3>Conclusions</h3> In hospitalized patients with hip fracture, there is a high prevalence of hypovitaminosis D which did not achieve a satisfactory decrease in the subgroup that received vitamin D supplements. <h3>Disclosure of Interest</h3> None Declared
EUS-guided choledochoduodenostomy for biliary drainage using tapered-tip plastic stent with multiple fangs
Authors: V. Prachayakul, P. Aswakul, U. Kachintorn
Journal: Endoscopy (2011)

A 52-year-old man presented with abdominal pain and jaundice for 2 months. Computed tomography (CT) revealed a huge mass at the pancreatic head causing distal common bile duct (CBD) obstruction with superior mesenteric vein and superior mesenteric artery encasement ([Fig. 1]).
Cardiac Sympathovagal Balance During Endoscopic Retrograde Cholangiopancreatography
Authors: M Petelenz, J Musialik, P Besser, M Gonciarz, M Sosnowski, Z Czyz, J Wilk, T Petelenz, Z Gonciarz
Journal: Endoscopy (2000)

Background and Study Aims: Cardiopulmonary complications have been reported during upper gastrointestinal endoscopy and endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to evaluate the sympathovagal response to the stretching of the common bile duct caused by contrast medium injection during ERCP.
Association of the Lewis Blood-Group Phenotype with Recurrent Urinary Tract Infections in Women
Authors: Joel Sheinfeld, Anthony J. Schaeffer, Carlos Cordon-Cardo, Andre Rogatko, William R. Fair
Journal: New England Journal of Medicine (1989)

Blood-group antigens are found on the surface of urothelial cells and may affect bacterial adherence and thereby the susceptibility to urinary tract infection. We determined the ABO, P, and Lewis blood-group phenotypes in 49 white women with histories of recurrent urinary tract infections and compared them with those found in 49 healthy control women without recurrent urinary tract infections. There was no significant difference between the two groups in the distribution of the ABO or P phenotypes. The distribution of Lewis blood-group phenotypes among control women was similar to that in the general population: secretor phenotype (Le(a-b+)), 74 percent; nonsecretor phenotype (Le(a+b-)), 18 percent; and recessive phenotype (Le(a-b-)), 8 percent. The following distribution was noted among the women with recurrent urinary tract infections: secretor phenotype, 45 percent; nonsecretor phenotype, 29 percent; and recessive phenotype, 26 percent (P = 0.002). When the women with nonsecretor and recessive phenotypes were combined and considered collectively, the odds ratio (an estimate of relative risk of recurrent urinary tract infection) for those without the secretor phenotype was 3.4 (95 percent confidence interval, 1.5 to 7.9). We conclude that there is an increased frequency of the Lewis blood-group nonsecretor (Le(a+b-)) and recessive (Le(a-b-)) phenotypes among women with recurrent urinary tract infections. (N Engl J Med 1989; 320:773–7.)
William Louis Murray Bigby James Aeneas Mackenzie Broadfoot Dorothy Frances Egan Kamel ("Kam") Hamadah Norman Dennis Woodrow
Authors: J. Mackeith, J. Broadfoot, B. Neville, T. Bewley, J. Woodrow
Journal: BMJ (1998)

Starting his career as a general practitioner, he played a major part in the civil defence of Southampton, for which he was awarded the MBE.After the war he returned to practice but soon trained in anaesthetics and became a
Abstract 4734: Genes cooperatively downregulated by combined mTOR/histone deactylase (HDAC) inhibition are overexpressed in myeloma patients with lower survival
Authors: Aleksandra M. Michalowski, John K. Simmons, Jyoti Patel, W Michael Kuehl, Shuling Zhang, Ola Landgren, Beverly A. Mock
Journal: Cancer Research (2012)

Abstract The molecular pathogenesis of many cancer types, including multiple myeloma (MM) and mantle cell lymphoma (MCL), involves alterations in the PI3K/Akt/mTOR and cyclin/CDK/CDKI/Rb (Rb) pathways. Previously, we showed that the combination of an HDAC inhibitor (HDACi) with rapamycin synergistically inhibited proliferation in 88% of human MM cell lines tested, and effectively controlled tumor growth in preclinical studies. To gain an initial understanding of the molecular mechanism of the synergistic action of the drug combination, we used an unbiased systems-level approach to analyze our gene expression profile (GEP) data with weighted gene co-expression network analysis (WGCNA). This analysis delineated the contribution of HDACi and rapamycin, singly and in combination, to the overall gene expression change of the combination by considering not only measures of fold-change and significance testing, but also the degree of gene expression inter-connectedness. WGCNA identified five gene modules, each representing a particular gene expression effect of the combination. Each gene module was individually tested for functional and clinical enrichment using gene set enrichment analysis (GSEA) and survival analyses with Cox regression. Of particular interest, the module containing genes cooperatively affected by both compounds was highly enriched (p&amp;lt;0.001) for genes involved in cell cycle (especially mitotic processes), immune recognition, and DNA damage/repair, which we investigated further. Genes down-regulated by the drug combination were most significantly correlated with genes over-expressed in MM patients. Furthermore, analysis of the cooperative drug signature in publicly available patient GEP datasets with survival annotation found it predictive of increased survival (p&amp;lt;0.01), thus linking the drug combination-induced transcriptional changes to predictions for enhanced survival. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4734. doi:1538-7445.AM2012-4734
AB1062 Gout: Clinical pattern at first evaluation, changes in the last 15 years:
Authors: J. Vazquez Mellado, C. Hernandez Cuevas, E. Estrada, R. García
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Younger age at onset and higher frequency of severe gout has been reported in some countries (1-3), when compared to previous reports. It seems that these patterns could be changing in the last years. <h3>Objectives</h3> To compare the clinical pattern of gout patients attended for the first time, in the same Rheumatology department, during the last 15 years. <h3>Methods</h3> Our Gout clinic receives 6-8/new patients each month, they had been evaluated by the same investigators in the last 15 years. We analyzed 568 gout patients from 3 groups: G1: n=316, (1995-2000) (3), G2: n=133m (2006-2007), G3: n=119 (2010-22). Variables: Demographic, clinical, biochemical and functional data regarding gout and associated diseases. Socioeconomic level according to Giuscaffre index; low educational level (&lt;6 years); severe tophaceous gout (&gt;10 tophi); renal failure (Creatinine clearance: &lt;50 mL/min). Hypertension, obesity and hypertriglyceridemia (according to ATPIII criteria definitions). Statistical analysis: t test, ANOVA, chi square and logistic regression. <h3>Results</h3> Data from the 3 groups: Males: 97%, age at evaluation: 50.01±12.93 and age at onset: 37.6±13.1 years. In the last 15 years, several demographic, clinical variables and previous treatment had significant changes. Main characteristics are shown in the table as percentages. <h3>Conclusions</h3> Although some social and clinical characteristics improved in the last 15 years (socioeconomic and educational level, severe tophaceous gout, renal failure and obesity). We attend now patients younger at onset, with higher frequency of familial gout, hypertension and functional impairment. <h3>References</h3> Tanaka E, Yamanaka H, Shoji A, et al. Recent trend in the onset age of gouty arthritis in Japan. Gout and Nucleic Acid Metabolism 2004; 28:7–11. Chen SY, Chen CL, Shen ML, Kamatani N. Trends in the manifestations of gout in Taiwan. Rheumatology (Oxford) 2003; 42:1529–1533. Vazquez-Mellado J, Cruz J, Guzman S, Casasola Vargas J, Lino L, Burgos Vargas R. Severe tophaceous gout. Characterization of low socioeconomic patients from México. Clin Exp Rheumatol 2006;24:233-238. <h3>Disclosure of Interest</h3> None Declared
Kinetics, function and bone marrow trafficking of CD4+CD25+FOXP3+ regulatory T cells in myelodysplastic syndromes (MDS)
Authors: I Kotsianidis, I Bouchliou, E Nakou, E Spanoudakis, D Margaritis, A V Christophoridou, A Anastasiades, C Tsigalou, G Bourikas, A Karadimitris, C Tsatalas
Journal: Leukemia (2008)
Indications for Surgery of the Upper Gastrointestinal Tract
Authors: Franz J. Ingelfinger, Guillermo C. Sanchez
Journal: New England Journal of Medicine (1954)

AMONG patients suffering from disorders of the upper gastrointestinal tract the problem of whether or not to undertake surgery is most frequently posed by those with peptic ulcer of the esophagus, stomach or duodenum. Less common, but sometimes requiring difficult decision, are cases of diaphragmatic hernia, esophageal varices, cardiospasm and gastritis. Any attempt to establish rigid criteria for surgery in these conditions is thwarted by the myriad combinations of pros and cons that emerge from consideration of any one case. One may, however, establish general indications for abandoning further medical management in favor of the results achievable by surgery.Peptic . . .
PTH-162 The Challenges of Implementing Evidence into Endoscopic Practice: A Qualitative Study
Authors: P T Rajasekhar, S Brown, C Nixon, M Bramble, J East, M Rutter, B Saunders, C Rees
Journal: Gut (2013)

<h3>Introduction</h3> The Quality Improvement in Colonoscopy (QIC) study was a region wide service improvement study that aimed to improve adenoma detection rate (ADR), and thusly quality in colonoscopy, through implementation of a ‘bundle’ of measures to routine colonoscopy practise. These were: withdrawal time ≥ 6 minutes; routine hyoscine butylbromide use; supine position to examine the transverse colon; rectal retroflexion. Each has been shown to improve adenoma detection. The implementation of evidence into clinical practise can be challenging. We performed a qualitative interview study to evaluate factors that influenced implementation of the ‘bundle’ in the QIC study. <h3>Methods</h3> The study took place in 12 units who are members of the Northern Region Endoscopy Group, a research network in the north east of England. The study team held training sessions in each unit to introduce the ‘bundle’, supported by a nominated local lead colonoscopist and nurse. Posters were supplied for each endoscopy room to aid promotion. Following QIC study completion units and individuals were purposively sampled for the qualitative interview study ensuring a range of units (by size, bundle uptake) were included. Semi-structured interviews were conducted until saturation was reached. Data were evaluated using thematic analysis to code and categorise interviews. <h3>Results</h3> 119 colonoscopists participated in the QIC study. Interviews were conducted with 11 participants. 8 were lead colonoscopists, 1 a lead nurse and 3 colonoscopists who weren’t leads. Increased emphasis on examination time, increased awareness of ADR as a quality marker and empowerment of endoscopy nurses to encourage use of quality measures were seen as positive impacts of introducing the ‘bundle’. The simple, highly visible posters were also reported as useful in aiding study promotion. Challenges included difficulty in arranging set up meetings and in engaging certain speciality groups. <h3>Conclusion</h3> Implementation of evidence into clinical practise can be challenging. During the QIC study, challenges included arranging staff meetings and engaging all team members. Positive outcomes included increased awareness of colonoscopy quality, particularly slower withdrawal times, and empowerment of endoscopy nurses to promote quality measures. We demonstrate that emphasis on timing of meetings and strategies to engage speciality groups should be given consideration when planning implementation of evidence or guidelines into clinical practise. <h3>Disclosure of Interest</h3> None Declared.
Efficacy of Recombinant Human Hyaluronidase-Facilitated Subcutaneous Infusion of Immunoglobulin G (IgG) (IGHy) in Patients with Primary Immunodeficiency Disease (PIDD): Infections over Time
Authors: Richard L. Wasserman, Mark R. Stein, Lisa J. Kobrynski, Sudhir Gupta, J. Andrew Grant, Arye Rubinstein, Christopher J. Rabbat, Werner Engl, Barbara McCoy, Heinz Leibl, Leman Yel
Journal: Journal of Allergy and Clinical Immunology (2016)
OP0134 Risk stratification in patients with undifferentiated arthritis according to the 2010 ACR/EULAR criteria
Authors: A. Krabben, A. Abhishek, K. Britsemmer, A. Filer, T.W.J. Huizinga, K. Raza, D. van Schaardenburg, A.H.M. van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2013)

Background Early recognition and treatment of Rheumatoid Arthritis (RA) is associated with an improved outcome. The 2010 ACR/EULAR criteria for RA identify RA patients earlier than the 1987 criteria. Nevertheless, we observed that 24% of the 2010-undifferentiated arthritis (UA) patients develop RA during follow-up. Objectives Here we studied this frequency in other cohorts and evaluated the prognostic accuracy of anti-CCP antibodies and the Leiden prediction rule in 2010-UA patients. Methods 2010-UA patients derived from three Early Arthritis Clinics were studied: 776 UA patients from Leiden, 121 from Birmingham and 322 from Amsterdam. Fulfilling the 1987 ACR criteria for RA during follow-up was studied as outcome. The presence of anti-CCP antibodies and the prediction score at baseline were evaluated in relation to the outcome. Results In the three cohorts, 24%, 26% and 12% of the 2010-UA patients fulfilled the 1987 criteria after one year, respectively. Some of these patients fulfilled the 1987 criteria already at baseline. In "1987-and-2010-UA patients'', 15%, 21% and 9% respectively developed RA. In all cohorts, the large majority of 2010-UA patients were anti-CCP negative and had low prediction scores at baseline. Therefore these markers were not helpful for risk stratification. Conclusions Some of the 2010-UA patients progress to RA. Anti-CCP antibodies and the Leiden prediction rule are not useful to identify these patients. Hence, other prognostic markers are needed with significantly different sensitivity and specificity characteristics to clinical examination; these may include imaging modalities such as ultrasound or extremity-MRI. Disclosure of Interest None Declared
Mechanical Small-Bowel Obstruction
Authors: Jacob Antonsen, Jorgen Tilma
Journal: New England Journal of Medicine (2014)

A 57-year-old woman presented with sudden-onset upper abdominal pain and vomiting. Her history was notable for type 1 diabetes and laparoscopic tubal sterilization. CT revealed small-bowel volvulus with dilated small bowel rotated around its blood supply.
Stat Bite: Trends in Colorectal Cancer Incidence
Authors: Lynn A. G. Ries
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Stat Bite: Trends in Colorectal Cancer Incidence Get access Lynn A. G. Ries Lynn A. G. Ries Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Page 1577, https://doi.org/10.1093/jnci/86.21.1577 Published: 02 November 1994