SAT0315 Comparison of Fast 1.5T Chest MRI with HRCT Scan in the Assessment of Interstitial Lung Disease Extension Secondary to Systemic Sclerosis
Authors: I. Pinal-Fernandez, V. Pineda-Sanchez, E. Pallisa Núñez, C.P. Simeόn-Aznar, A. Selva-O'Callaghan
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Interstitial lung disease (ILD) is a potentially severe manifestation of patients with systemic sclerosis (SSc). High-resolution computed tomography (HRCT) is the reference test for diagnosis and follow-up. <h3>Objectives</h3> Our objective was to analyze the performance of the MRI, a non-ionizing exploration, compared with the HRCT, to assess the extension of SSc-associated ILD. <h3>Methods</h3> We retrospectively collected data of patients with different degrees of ILD due to SSc in which a 1.5T chest MRI (using a 15-seconds HASTE sequence) and a HRCT were performed in a maximum interval of one year. A previously validated HRCT score and new MRI score were performed to assess the extension of the ILD. Composite scores were created to make the comparisons. The regression, correlation and anatomical distribution of MRI compared with HRCT were calculated. <h3>Results</h3> Twelve patients were studied (11 women). A strong correlation was found between general MRI and total HRCT composite scores (r=0.70, <i>p</i>=0.01) with a significant linear relationship between them (p=0.01); a moderate correlation was observed between the general MRI and the HRCT fibrosis composite scores (r=0.64, p=0.02), also with a significant linear relationship (p=0.03). The distribution of the MRI and the HRCT composite scores was comparable, showing a predominant distribution of ILD findings in the lower zones of both lungs. <h3>Conclusions</h3> Compared with HRCT, our new MRI extension score using a 15-second-sequence MRI showed good correlation, significant linear relationship and similar anatomic distribution, suggesting that MRI may be reliable to assess the extension of ILD in SSc patients. <h3>References</h3> Brenner DJ, Hall EJ. Computed tomography–an increasing source of radiation exposure. The New England journal of medicine 2007;357:2277-84. Muller NL, Mayo JR, Zwirewich CV. Value of MR imaging in the evaluation of chronic infiltrative lung diseases: comparison with CT. AJR American journal of roentgenology 1992;158:1205-9. Lutterbey G, Grohe C, Gieseke J, et al. Initial experience with lung-MRI at 3.0T: Comparison with CT and clinical data in the evaluation of interstitial lung disease activity. European journal of radiology 2007;61:256-61. Lutterbey G, Gieseke J, von Falkenhausen M, Morakkabati N, Schild H. Lung MRI at 3.0 T: a comparison of helical CT and high-field MRI in the detection of diffuse lung disease. European radiology 2005;15:324-8. McFadden RG, Carr TJ, Wood TE. Proton magnetic resonance imaging to stage activity of interstitial lung disease. Chest 1987;92:31-9. Gaeta M, Blandino A, Scribano E, et al. Chronic infiltrative lung diseases: value of gadolinium-enhanced MRI in the evaluation of disease activity–early report. Chest 2000;117:1173-8. Yi CA, Lee KS, Han J, Chung MP, Chung MJ, Shin KM. 3-T MRI for differentiating inflammation- and fibrosis-predominant lesions of usual and nonspecific interstitial pneumonia: comparison study with pathologic correlation. AJR American journal of roentgenology 2008;190:878-85. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1587