tbuckley/cabot-search huggingface dataset:
PRIMARY MYOCARDIAL DISEASE
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Maria Gordon Buse, MD: A Family Affair Through Six Decades of Diabetes Discovery
Authors: Charles F. Burant, Caroline R. Buse, Katherine A. Robinson, John B. Buse
Journal: Diabetes Care (2016)

Maria Gordon Buse, MD, is a product of wartime Europe. She completed her professional education in four languages on three continents and continues a nearly 60-year career as an investigator, educator, and practicing endocrinologist. This brief reprisal is written collaboratively by her biological offspring and intellectual progeny, an appropriate reflection of a career where family and work were joyfully intertwined in an irresolvable way.

Maria Gordon Buse was born Maria Felice Gordon in Budapest, Hungary. Her mother, Elizabeth Szana, was the “great beauty” of her social circle, and her father, Geza, was an earnest accountant who tried his hand at several failed entrepreneurial activities before buying a cafe on the Danube near the symphony hall. In that venture, Elizabeth’s charms and Geza’s practical business acumen resulted in a successful enterprise that was a gathering place for students, artists, and the middle class in Budapest. Maria was raised speaking German in the home and only learned Hungarian when she went to school. She mastered French as a third language in middle school. Maria loved poetry, literature, theater, art, music, walking in the woods during trips to the nearby mountains, and ice skating. She aspired to become a poet and a journalist. She was 16 in 1943 when German troops occupied Budapest. Through the intercession of friends, Maria and her mother took refuge in a cloister, and her father, in a monastery. Her mother was fearless about going out into the city through bombings and gunfire, leveraging her many social connections to find food and supplies. Maria never takes for granted how lucky she and her family were to survive. As the Allies approached to “liberate” Hungary, she recalls laughing at the sky, seeing the showering bombs as symbolic of their impending freedom and the justice that the Axis powers would face. …
Yersinia enterocolitica O:9 infections associated with bagged salad mix in Norway, February to April 2011
Authors: E MacDonald, B  T Heier, T Stalheim, K S Cudjoe, T Skjerdal, A Wester, B A Lindstedt, L Vold
Journal: Eurosurveillance (2011)

In March 2011, the Norwegian Institute of Public Health identified a possible outbreak involving 21 cases of Yersinia enterocolitica O:9 infection with similar MLVA-profiles. Preliminary results of epidemiological and microbiological investigations indicate bagged salad mix containing radicchio rosso (also known as Italian chicory) as a possible source. As a result of the investigation, bagged salad mixes of a specific brand were voluntarily withdrawn from the market by the producer.
Case 18-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Michael E. Weinblatt, Robert Fienberg
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 31-year-old woman was admitted to the hospital because of asthma and neurologic deficits.There was a four-year history of occasional episodes of asthma, with intermittent treatment by corticosteroids during the five months before entry. The patient was otherwise well until about 10 weeks before admission, when hyposensitization therapy was begun with dust and mite antigens. After the second dose of antigen therapy fever, urticaria, purpura, and arthritis developed. She was admitted to another hospital, where laboratory studies revealed eosinophilia and an erythrocyte sedimentation rate of 45 mm per hour. An x-ray film of the chest disclosed . . .
Potentially avoidable hospital admissions in older patients with acute myeloid leukaemia in the USA: a retrospective analysis
Authors: Areej El-Jawahri, Tanya Keenan, Gregory A Abel, David P Steensma, Thomas W LeBlanc, Yi-Bin Chen, Gabriela Hobbs, Lara Traeger, Amir T Fathi, Daniel J DeAngelo, Martha Wadleigh, Karen K Ballen, Philip C Amrein, Richard M Stone, Jennifer S Temel
Journal: The Lancet Haematology (2016)
Vitamin E in the treatment of tardive dyskinesia
Authors: A M Elkashef, P E Ruskin, N Bacher, D Barrett
Journal: American Journal of Psychiatry (1990)

Eight subjects with persistent tardive dyskinesia were treated with vitamin E and placebo in a randomized, double-blind crossover study. Their mean score on the Abnormal Involuntary Movement Scale (AIMS) was significantly lower after treatment with vitamin E than after placebo administration.
Dietary Standards
Authors: D. M. Hegsted
Journal: New England Journal of Medicine (1975)

Dietary standards, such as the Recommended Dietary Allowances (RDA),1 are used for two primary purposes —to plan diets for individuals or groups of people, and to evaluate the nutritional adequacy of the foods eaten. Although much has been written about what the standards represent and how they should be used, a variety of questions remain unanswered.nutritional standards represent a judgment based upon practical experience with individuals or groups of individuals consuming diets of differing nutrient content, studies specifically designed to evaluate nutrient requirements of human subjects, and similar studies on the nutrient requirements of animals. The fact that different . . .
Soundings: The big difference
Authors: Trisha Greenhalgh
Journal: BMJ (2002)

I recently spent five days in a private hospital, where I had a routine operation. A few days later, for reasons with which I won't bore you, I was admitted to an NHS hospital, where I had another operation. This was hardly a randomised controlled trial, but it did make for some interesting comparisons.

In terms of creature comforts, the private hospital won hands down. My room had a plush carpet, an en suite bathroom, and a wide screen television with 24 channels (four of them in Arabic). I chose my meals from a leather bound menu (and, had I wanted to, I could have washed them down with champagne and smoked a cigar afterwards).

But otherwise, the differences were hard to spot. The beds were of identical make and model, with the same crisp white sheets (incidentally, mine were changed more often in the NHS). The nurses were all angels. The doctors were equally efficient, committed, and highly skilled. The operating theatres were equally spotless and well equipped; the anaesthetic rooms equally scary. I threw up approximately the same amount in each recovery room.

So apart from the frills, what was the big difference? I think it was this. In the private sector, no one entered my room without requesting my permission, and they did so in such a way (“Is it OK to empty your bin?”; “Is it convenient to take your blood pressure now?”) that I really believed I could turn them down.

In the NHS, where I was also in a room of my own, the door swung open six times an hour and staff breezed cheerily in and out as they collected equipment, checked my chart, or hunted down the senior house officer. The only person to knock on my door and wait for a reply before entering was my husband.

Nothing dreadful resulted (I was only caught unawares on a bedpan once), and if I had not just come from a hospital with a different culture I'm sure I wouldn't have noticed. But here's the lesson I learnt. Being a patient—especially a bed-bound one—does nothing for your self esteem. When people value your privacy, they make you feel valued as a person.

I didn't miss the telly, and I can handle drinking tea out of a cardboard cup. But a little respect for privacy—which, ironically, costs nothing—could put the NHS on a level footing with Harley Street.
The Intrauterine Device and Primary Tubal Infertility
Authors: J R Daling, N S Weiss, L F Voigt, B McKnight, D E Moore
Journal: New England Journal of Medicine (1992)

The results of a population-based retrospective case-control study published in 1985 on the link between prior use of an IUD and primary tubal infertility have been re-analyzed.  The original results set the relative risk of tubal infertility at 2.6 for ever users of an IUD but 6.8 for users of the Dalkon shield.  The new calculations eliminated cases of infertility due to abnormalities verified by hysterosalpingography such as bicornuate uterus or uterine polyps; included 15 cases for whom no matched controls with the same matching criteria.  The new data set included 487 of 518 potential controls for 161 cases.  The new computation yielded a relative risk of 3.7 for ever-use of any IUD 3.9 for ever-use of a copper IUD 6.0 for ever-use of a Dalkon shield and 3.4 for ever-use of any IUD except the Dalkon shield.  These results did not change the original interpretation of the study:  that while the risks of infertility is heightened after use of the Dalkon shield it is still higher after use of any IUD for nulligravid women.
Predictors of acute dystonia in first-episode psychotic patients
Authors: E J Aguilar, M S Keshavan, M D Martínez-Quiles, J Hernández, M Gómez-Beneyto, N R Schooler
Journal: American Journal of Psychiatry (1994)

Sixty-two first-episode psychotic patients who were neuroleptic-naive were studied to examine predictors of acute dystonia after treatment with haloperidol. Twenty-three patients developed dystonia, two of them despite being treated with biperiden. Biperiden significantly prevented dystonic reactions. Dystonia development was significantly related to younger age, severity of illness, and negative symptoms at baseline and showed a trend to be related to positive symptoms as well. No significant effect of gender or diagnosis was found. The authors suggest that young, severely ill patients in their first psychotic episode who have never been treated with neuroleptics might be at higher risk to develop dystonia.
Liver Transplantation in Older Patients
Authors: T E Starzl, S Todo, R Gordon, L Makowa, A Tzakis, S Iwatsuki, W Marsh, C Esquivel, D Van Thiel
Journal: New England Journal of Medicine (1987)

To the Editor: The impact of liver transplantation on public health policy has not been delineated, partly because of uncertainty about the upper age limit for candidacy. We have compared the outlook in 363 adult recipients of livers who were less than 50 years old (mean +SD, 35.8+8.5) and 92 recipients who were 50 to 77 years old (mean +SD, 55.7+4.8). Cyclosporine and steroids1,2 were used for immunosuppression, and monoclonal antilymphocyte globulin3 and azathioprine were added as needed. The techniques of liver transplantation4 were not influenced by the age of the patient. The indications for transplantation are shown in Figure 1…., No extract is available for articles shorter than 400 words. © 1987, Massachusetts Medical Society. All rights reserved.
Endoscopic ultrasound-guided histological diagnosis of a mucinous non-neoplastic pancreatic cyst using a specially designed through-the-needle microforceps
Authors: Fabia Attili, Danilo Pagliari, Mihai Rimbaș, Frediano Inzani, Maria Brizi, Guido Costamagna, Alberto Larghi
Journal: Endoscopy (2016)

Solitary uniloculated pancreatic cysts pose a major diagnostic dilemma. Cystic fluid carcinoembryonic antigen (CEA) concentration and cytology have low sensitivity in distinguishing mucinous from non-mucinous cysts [1], leading to frequent misdiagnoses and unnecessary surgical interventions [2]. Recently evaluated molecular markers seem very accurate, but they are not widely available in clinical practice [3].
Abstract BS3-1: Dominance of mitochondria in determining the malignant phenotype
Authors: BA Kaipparettu
Journal: Cancer Research (2016)

Abstract Mitochondria are semiautonomous organelles within cells that play an important role in cellular energy metabolism, free radical generation, and apoptosis. Mitochondria contain their own genome (mtDNA), which encodes a number of proteins critical for energy metabolism, particularly in oxidative phosphorylation. They are also the major source of generating reactive oxygen species (ROS) in the cell. Advances in cancer metabolism research over the last decade have enhanced and modified our understanding on Warburg effect. It is now known that mitochondria in tumors are not always defective in their ability to carry out oxidative phosphorylation. Instead, in proliferating cells, mitochondrial energy pathways are reprogrammed to meet the challenges of macromolecular synthesis and to escape from apoptosis. Mitochondrial retrograde regulation (MRR) is a bidirectional communication between mitochondria and nucleus. MRR is triggered by mitochondrial functional demands and it responds in a continuous manner to the changing metabolic needs of the cell. At present, it is not clear whether mitochondrial genomic status or metabolomic reprogramming affect nuclear genome stability. Also, limited evidence is available on the significance of proteins involved in the inter-genomic cross talk in the regulation of tumorigenesis. Transmitochondrial cybrids (cybrids) are a great utility for the study of the functional effects of mitochondria in a defined nuclear background. Cybrids are constructed by fusing enucleated cells harboring mitochondria of interest with ρ0 cells (mtDNA-depleted cells). Our approach of discovering mitochondria regulated pathways using cybrid models and their in vitro and in vivo validation in different breast cancer cell lines and patient derived xenograft models suggest that mitochondrial metabolic character and retrograde signaling are playing important roles in oncogenic transformation and metastasis. Importantly, mitochondria-nuclear crosstalk is critical in the regulation of some of the major cancer pathways. Compared to hormone regulated/responsive breast cancers, triple negative breast cancer patients suffer from worse overall survival, significantly shorter disease-free and post-recurrence survival. Due to the lack of known oncogenic drivers for triple negative breast cancer, clinical benefit from currently available targeted therapies is limited, and new therapeutic strategies are urgently needed. Thus, understanding MRR and mitochondria mediated oncogenic signature is critical in understanding the currently limited known etiology and treatment resistance of certain subgroups of cancers like the triple negative breast cancer. Citation Format: Kaipparettu BA. Dominance of mitochondria in determining the malignant phenotype. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr BS3-1.
Predictive Value Of Early Molecular Responses In Outcomes Of Patients With Chronic Myeloid Leukemia Treated With Imatinib In First-Line Therapy
Authors: Katia B. Pagnano, Bruna Vergilio, Eliana C M Miranda, Marcia Torresan Delamain, Maria Helena De Almeida, Vagner O Duarte, Gislaine O. Duarte, Carmino A De Souza, Irene Lorand-Metze
Journal: Blood (2013)
Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2
Authors: June L. Biedler, Hansjörg Riehm, Robert H. F. Peterson, Barbara A. Spengler
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells Get access June L. Biedler, June L. Biedler Search for other works by this author on: Oxford Academic PubMed Google Scholar Hansjörg Riehm, Hansjörg Riehm Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert H. F. Peterson, Robert H. F. Peterson Search for other works by this author on: Oxford Academic PubMed Google Scholar Barbara A. Spengler Barbara A. Spengler Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 3, September 1975, Pages 671–680, https://doi.org/10.1093/jnci/55.3.671 Published: 01 September 1975 Article history Received: 07 March 1975 Accepted: 09 May 1975 Published: 01 September 1975
Screening for Chlamydial Infection: U.S. Preventive Services Task Force Recommendation Statement
Journal: Annals of Internal Medicine (2007)

Description: Update of 2001 U.S. Preventive Services Task Force (USPSTF) recommendations about screening sexually active adolescents and adults for chlamydial infection. Methods: The USPSTF weighed the benefits (improved fertility, pregnancy outcomes, and infection transmission) and harms (anxiety, relationship problems, and unnecessary treatment of false-positive results) of chlamydial screening identified in their 2001 recommendations and the accompanying systematic review of English-language articles published between July 2000 and July 2005. Recommendations: Screen for chlamydial infection in all sexually active nonpregnant young women age 24 years or younger and for older nonpregnant women who are at increased risk. (A recommendation) Screen for chlamydial infection in all pregnant women age 24 years or younger and in older pregnant women who are at increased risk. (B recommendation) Do not routinely screen for chlamydial infection in women age 25 years or older, regardless of whether they are pregnant, if they are not at increased risk. (C recommendation) Current evidence is insufficient to assess the balance of benefits and harms of screening for chlamydial infection for men. (I statement) *For a list of the members of the U.S. Preventive Services Task Force, see the Appendix.
Abstract IA12: SWI/SNF (BAF) complex mutations in cancer
Authors: Charles W. M. Roberts
Journal: Cancer Research (2016)

Abstract Data emerging over the last several years implicate the SWI/SNF (BAF) chromatin remodeling complex as a major tumor suppressor as frequent inactivating mutations in at least eight SWI/SNF subunits have been identified in a variety of cancers. These include inactivating mutations of the gene encoding the ARID1A (BAF250a) subunit in ovarian, endometrioid, bladder, stomach, colorectal and pancreatic cancers; of the PBRM1 (BAF180) subunit in renal carcinomas; of the ARID2 subunit in hepatocellular, lung, and pancreas carcinomas as well as melanomas; of the BRD7 subunit in breast cancers; and of the BRG1 (SMARCA4) subunit in non-small cell lung cancers, medulloblastomas and ovarian small cell carcinomas. The SWI/SNF complex includes both core and lineage-specific subunits and utilizes the energy of ATP to modulate chromatin structure and regulate transcription. My laboratory began studying the SWI/SNF complex when the SNF5 (SMARCB1/INI1/BAF47) subunit was first identified as a tumor suppressor over a decade ago when it was found to be recurrently and specifically inactivated in a highly aggressive type of pediatric cancer called malignant rhabdoid tumor. We now study the complex using mouse models, cell lines and primary human tumor samples. Our goals are to elucidate the normal function of the complex, identify the mechanisms by which subunit mutations drive cancer formation, and utilize this insight to identify and develop novel therapeutic approaches. Insights into the normal function of SWI/SNF complexes, the mechanisms by which mutation of the complexes drive cancer formation, and potential therapeutic vulnerabilities created by mutation of the complex will be presented. Citation Format: Charles W. M. Roberts. SWI/SNF (BAF) complex mutations in cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; 2015 Nov 9-12; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(5 Suppl):Abstract nr IA12.
Herpes simplex encephalitis
Authors: L Poulsgård, K D Nielsen, M R Buhl
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Palliative Care for Patients With End-Stage Cardiovascular Disease and Devices
Authors: James N. Kirkpatrick, Paul J. Hauptman, Keith M. Swetz, Elizabeth D. Blume, Kimberlee Gauvreau, Mathew Maurer, Sarah J. Goodlin
Journal: JAMA Internal Medicine (2016)

The adenoma was surgically removed by a transsphenoidal approach.The patient's postoperative course was uneventful.Normalization of 24-hour urinary free cortisol level was achieved 4 days after surgery (200 nmol/24 hours).Histological examination confirmed the diagnosis of corticotroph pituitary adenoma.At 6 months, postoperative MRI confirmed total resection of the adenoma (Figure 2B).The patient had lost 12 kg, the purple marks had significantly decreased, endocrine functions were normalized, and he now continues to play his guitar.