tbuckley/cabot-search huggingface dataset:
RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus
Authors: Shoko Nogusa, Roshan J. Thapa, Christopher P. Dillon, Swantje Liedmann, Thomas H. Oguin, Justin P. Ingram, Diego A. Rodriguez, Rachelle Kosoff, Shalini Sharma, Oliver Sturm, Katherine Verbist, Peter J. Gough, John Bertin, Boris M. Hartmann, Stuart C. Sealfon, William J. Kaiser, Edward S. Mocarski, Carolina B. López, Paul G. Thomas, Andrew Oberst, Douglas R. Green, Siddharth Balachandran
Journal: Cell Host & Microbe (2016)
Monoclonal antibody immunocytology: potential applications for staging and monitoring malignant disease activity.
Authors: I Royston, R E Sobol
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.4.453 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3981222 Monoclonal antibody immunocytology: potential applications for staging and monitoring malignant disease activity. I RoystonxI RoystonSearch for articles by this author , R E SobolxR E SobolSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.4.453 PDF "Monoclonal antibody immunocytology: potential applications for staging and monitoring malignant disease activity.." Journal of Clinical Oncology, 3(4), pp. 453–454© 1985 by American Society of Clinical Oncology
Disentangling (Epi)Genetic and Environmental Contributions to the Mitochondrial 3243A&gt;G Mutation Phenotype
Authors: Martin Picard, Michio Hirano
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Surveillance of meningococcal disease in France, 1990-1997
Authors: B Hubert, V Goulet, J. Y. Riou
Journal: Eurosurveillance (1997)

The surveillance of meningococcal disease in France is based on four complementary sources of data. 1. Meningococcal disease has been a notifiable disease since 1902. A case definition for surveillance was introduced in 1985, based on the isolation of Ne
“Pseudotumor” of the Stomach
Authors: J.H. Solhaug, A.R. Rosseland
Journal: Endoscopy (1985)

Persistent pathological changes at endoscopy are reported in three patients. At explorative laparotomy the changes were seen to be caused by neighbouring organs (splenic artery, pancreas and gallbladder). A correct diagnosis of “pseudotumor” of the stomach is necessary to avoid unwarranted surgery or unnecessary biopsies.
Brave new world
Authors: Des Spence
Journal: BMJ (2008)

The year is 2084. Much has changed in the past few decades since the Health and Safety Executive, supported by the medical profession, seized power to prevent dissidents blocking the safety laws. This legislation freed the population by prohibiting the menaces (recognised through “top” research) of sunlight, sexual intercourse, more than 2 cl of alcohol, sausages, swimming, cooking, peanuts, chocolate, comedy, fizzy drinks, members of the opposite sex, tattoos, rock music, Elvis, motorbikes, and religion.

Other enlightening legislation had followed. The Emancipation of Young Adults Act extended the franchise to children. Subsequently, a child led coalition (supervised by a responsible adult) voted to end the terrible oppression known as education and closed the schools. Unfortunately, to protect the children, all trees had been chainsawed, skate boards and bikes confiscated, and play parks bulldozed. Likewise, sport had been banned for the inherent evil of competitiveness, with the term “loser” erased from the English lexicon. Everyone was now a “Winner,” with cheap looking medals awarded every day just for turning up. Regrettably, kids were left with only “esteem” counselling as an approved activity.

To help these bored children the Virtual Reality Act was passed. With the compulsory wearing of 3D virtual reality visors, people were free to sky dive, ski, and ride motorbikes from the comfort of their sofas. Benevolent multinational fast food chains were awarded national contracts to deliver food to the door. The consequence, however, was obesity. Despite being safe, the people were unhappy.

The medical profession seemed impotent to help. For legal reasons, time was spent completing feedback questionnaires and listening to focus groups, but the real problem was that staff were either off sick or attending health and safety courses on the use of scissors and step ladders. Also, new anti-discrimination legislation meant that employers couldn’t ask applicants about age, gender, height, weight, address, school, qualifications, name, ethnicity, and hobbies. All CVs were therefore blank, and the only legally acceptable interview question was: “What is your favourite piece of cutlery?” Lastly, new working time directives limited work to one hour a day, and anti-bullying policies meant that no one could force employees to do anything.

But none of this mattered any more, for the compulsory injection of stem cell “hybrid” human-pig genes to cure the obesity problem had rendered humankind sterile. And no one seemed to care.
Avian influenza A(H5N1) – current situation
Authors: A Melidou
Journal: Eurosurveillance (2009)

The A(H5N1) influenza virus has re-emerged in 2003 in Asia, Africa, the Pacific Region as well as Europe and since then has become endemic in some countries. The virus is usually highly pathogenic and is associated with high morbidity and overall mortality rates that reach 61%.
Thyroid Hormones and Moderate Exposure to Perchlorate during Pregnancy in Women in Southern California
Authors: Craig Steinmaus, Michelle Pearl, Martin Kharrazi, Benjamin C. Blount, Mark D. Miller, Elizabeth N. Pearce, Liza Valentin-Blasini, Gerald DeLorenze, Andrew N. Hoofnagle, Jane Liaw
Journal: Environmental Health Perspectives (2015)

Findings from national surveys suggest that everyone in the United States is exposed to perchlorate. At high doses, perchlorate, thiocyanate, and nitrate inhibit iodide uptake into the thyroid and decrease thyroid hormone production. Small changes in thyroid hormones during pregnancy, including changes within normal reference ranges, have been linked to cognitive function declines in the offspring.We evaluated the potential effects of low environmental exposures to perchlorate on thyroid function.Serum thyroid hormones and anti-thyroid antibodies and urinary perchlorate, thiocyanate, nitrate, and iodide concentrations were measured in 1,880 pregnant women from San Diego County, California, during 2000-2003, a period when much of the area's water supply was contaminated from an industrial plant with perchlorate at levels near the 2007 California regulatory standard of 6 μg/L. Linear regression was used to evaluate associations between urinary perchlorate and serum thyroid hormone concentrations in models adjusted for urinary creatinine and thiocyanate, maternal age and education, ethnicity, and gestational age at serum collection.The median urinary perchlorate concentration was 6.5 μg/L, about two times higher than in the general U.S.Adjusted associations were identified between increasing log10 perchlorate and decreasing total thyroxine (T4) [regression coefficient (β) = -0.70; 95% CI: -1.06, -0.34], decreasing free thyroxine (fT4) (β = -0.053; 95% CI: -0.092, -0.013), and increasing log10 thyroid-stimulating hormone (β = 0.071; 95% CI: 0.008, 0.133).These results suggest that environmental perchlorate exposures may affect thyroid hormone production during pregnancy. This could have implications for public health given widespread perchlorate exposure and the importance of thyroid hormone in fetal neurodevelopment.Steinmaus C, Pearl M, Kharrazi M, Blount BC, Miller MD, Pearce EN, Valentin-Blasini L, DeLorenze G, Hoofnagle AN, Liaw J. 2016. Thyroid hormones and moderate exposure to perchlorate during pregnancy in women in Southern California. Environ Health Perspect 124:861-867; http://dx.doi.org/10.1289/ehp.1409614.
Abstract 14725: Association of Adipokines With Subclinical Myocardial Dysfunction - The Multi-Ethnic Study of Atherosclerosis (MESA)
Authors: Mohammad R Ostovaneh, Bharath Ambale Venkatesh, Kihei Yoneyama, Shishir Sharma, Matthew A Allison, Philip Greenland, Colin O Wu, David A Bluemke, João A Lima
Journal: Circulation (2015)

Background: Adipokines such as adiponectin, leptin and resistin have been associated with heart failure. We explore the association of adipokines and myocardial fibrosis as MRI-derived measure of subclinical myocardial dysfunction. Methods: For the current analysis, we studied MESA subjects who had adiponectin, leptin, resistin and TNF-α measured at second/third follow-up exams (2003-2005) and underwent post gadolinium MRI T1 mapping at 25 minutes for assessment of myocardial fibrosis at the fifth follow-up exam (2010 -2012). Linear regression analysis was used to evaluate the association of log-transformed adipokine levels with T1 time. BMI-stratified analysis was performed when the interaction term of BMI and adipokines was significant. Lower T1 time reflects greater myocardial fibrosis. Results: Four hundred and twenty three subjects (mean age: 61.4(8.1), 187 females) were included in the analysis. Median values of adiponectin, leptin, resistin and TNF-α were 16.9 μg/ml (IQR: 11-25), 11.1 ng/ml (IQR:5-25), 14 ng/ml(IQR:11-17) and 4.5 pg/ml(IQR:3.5-5.9). Higher adiponectin was associated with lower degree of myocardial fibrosis in subjects with BMI&lt;25 (p = 0.005). Higher leptin in individuals with BMI≥30 (p&lt;0.001) and higher resistin in those with BMI&lt;25 (p=0.02) was associated with greater myocardial fibrosis. Conclusion: Higher adiponectin is associated with lower degree of myocardial fibrosis in normal weight subjects. Leptin in obese individuals and resistin in those with normal BMI are positively associated with myocardial fibrosis.
HG-96FUNCTIONAL INTEGRITY OF THE BLOOD-BRAIN BARRIER IN H3.3K27M DIPG XENOGRAFTS
Authors: Nagore G. Olaciregui, Andres Morales La Madrid, Carles Monterrubio, Guillem Pascual-Pasto, Alejandro Manzanares, Ofelia Cruz, Jaume Mora, Angel M. Carcaboso
Journal: Neuro-Oncology (2016)
HG-70DRUG DELIVERY IN DIFFUSE INTRINSIC PONTINE GLIOMA: A BARRIER TO OVERCOME
Authors: S.E.M. Veldhuijzen van Zanten, F.E. El-Khouly, D.G. van Vuurden, N.H. Hendrikse, G.L. Kaspers
Journal: Neuro-Oncology (2016)

HG-70. DRUG DELIVERY IN DIFFUSE INTRINSIC PONTINE GLIOMA: A BARRIER TO OVERCOME S.E.M. Veldhuijzen van Zanten1, F.E. El-Khouly1,2, D.G. van Vuurden1, N.H. Hendrikse2,3, and G.L. Kaspers1; VU University Medical Center, Department of Pediatric Oncology-hematology, Amsterdam, The Netherlands; VU University Medical Center, Department of Clinical Pharmacology and Pharmacy, Amsterdam, The Netherlands; VU University Medical Center, Department of Nuclear Medicine & PET Research, Amsterdam, The Netherlands INTRODUCTION:DiffuseIntrinsicPontineGlioma(DIPG)isadeadlychildhoodbrain tumor.Despitedecadesof clinical trials, the survival-rateofDIPGpatients remains poor. It is hypothesized that this is partly due to an intact blood-brain-barrier (BBB) preventing chemotherapeutics from reaching the tumor properly. Our study aims to develop a model that is able to predict whether a chemotherapeutic drug is suitable to pass an intact BBB after systemic administration, or whether it should be administered locally via ConvectionEnhanced Delivery (CED). METHODS: A theoretical model was developed which includes all physicochemical properties that affect passive diffusion through the BBB, including lipophilicity, molecular weight and charge in physiological environment. Subsequently, themodelwasappliedtochemotherapeutic drugs previously administered to DIPG patients to determine the likeliness of success of systemic or local administration. RESULTS: Hydrophilic drugs with a high dissociation in physiological environment, and relatively large drugs, do not passively diffuse through the BBB. Of all drugs, only carmustine, lomustine and erlotinib appear to be suitable for systemic administration in case of an intact BBB. Administration via CED creates more therapeutic options, only excluding drugs with a positive charge in physiological environment. CONCLUSION: Our model shows that chemotherapeutics administered systemically in the past few decades to children suffering from DIPG, do not reach the tumor in theory. Partly explaining why we have not seen clinical effect thus far. Bypassing the BBB via CED seems to create more therapeutic options. In general, other novel techniques bypassing this BBB should also be explored. Neuro-Oncology 18:iii48–iii77, 2016. doi:10.1093/neuonc/now073.66 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Long-term outcome of jejuno-ileal bypass surgery for superobesity: a psychiatric assessment
Authors: P Castelnuovo-Tedesco, J Weinberg, D C Buchanan, H W Scott
Journal: American Journal of Psychiatry (1982)

In this study of the long-term psychosocial consequences of jejuno-ileal bypass, 24 patients were assessed with psychiatric interviews and psychological tests 4-12 years after the procedure. Twenty patients had had a good overall response to the surgery, and 4 had had a poor response. Most complications, physical and psychiatric, occurred during the first 3 years. Most patients with a good postoperative result maintained it for many years, gained occupationally and vocationally, were pleased with the results of the operation, and were willing to recommend it to others. Even those who had experienced complications tended to underrate their seriousness and to express satisfaction.
MB-107REST ELEVATION UNRESTRAINS SHH SIGNALING IN MEDULLOBLASTOMA
Authors: Rong-Hua Tao, Tara Dobson, Shavali Shaik, Pete Taylor, Rashieda Hatcher, William Brugmann, Ellen Busschers, Bridget Kennis, Soumen Khatua, Wafik Zaky, Rishi Lulla, Stewart Goldman, Tobey MacDonald, Cynthia Hawkins, Veena Rajaram, Jason Fangusaro, Vidya Gopalakrishnan
Journal: Neuro-Oncology (2016)
A process of establishing norms for inpatients length of stay in a community mental health center
Authors: O D Weiner, M S Levine
Journal: American Journal of Psychiatry (1975)

A pervasive sense of urgency, stimulated by the Social Security Amendments of 1972 (Public Law 92-603), attends the need to establish norms for length of stay for impatient services in mental health facilities and to provide review mechanisms for extended care cases. The authors describe one model, adaptable to changing needs and federal regulations, that can offer a beginning experience in this endeavor.
THE FUNCTIONS OF THE CEREBROSPINAL FLUID
Authors: R MARGARIA
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glutamatergic Dysfunction in Schizophrenia Evaluated With Magnetic Resonance Spectroscopy
Authors: Joseph T. Coyle, Glenn Konopaske
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Is there room for improving case management for contacts of meningococcal disease in the European Union?
Authors: P L Lopalco
Journal: Eurosurveillance (2008)

Invasive meningococcal disease (IMD) is a severe illness primarily affecting children and young adults. It has a high case fatality rate (10%-14%) and 11%-19% of patients who recover experience permanent hearing loss, mental retardation, loss of limbs or other serious sequelae.
Book: The Science and Fiction of Autism
Authors: Iain McClure
Journal: BMJ (2006)

Autism is thought to affect 60 in 10 000 children and is, in nearly all cases, a lifelong and incurable syndrome. It is, however, compatible with a normal life span, and modern interventions are generating ever increasing financial costs to families and society.​society.




Figure 1



Laura Schreibman

Harvard University Press, £17.95/€23.80/$27.95, pp 288 ISBN 0 674 01931 8 www.hup.harvard.edu

Rating: ★★★⋆




A recent US government forecast predicts that in 10 years' time the annual cost associated with autism may be between $200bn (£110bn; €138bn) and $400bn. Given this staggering figure, it seems incumbent on anyone affected by autism or involved in its management to get as much objective information about it as possible. However, type “autism” into Google and you'll get over 37 million hits. So how does anyone get genuine evidence to inform and guide families and colleagues? One way is to consult overviews by experienced clinicians and researchers—and in this compact account Laura Schreibman (professor of psychology at the University of California) has tried to summarise the evidence, with the aim of encouraging “the critical approach necessary to make sure we stay on the road to discovery.” Has she succeeded?

In a novel approach Schreibman starts by considering the disorder from the perspective of its numerous controversies. So, we are taken through a helpful account of the limitations and complexity of behavioural research, the curious characteristics of autism, its possible causes, its necessarily complex assessment, and the many interventions that have been tried over the years. Schreibman's approach is mostly successful and brings many experienced insights and (for me) new information. I appreciated her clear evaluation of the relation between autism and attachment behaviour (an area that is confusing, even to experienced clinicians), her respectful demolition of Bettelheim's flawed psychodynamic explanation of autism, and her clarification of the whole concept of “theory of mind.”

Therefore I was surprised, as I reached the halfway point, that I began to feel a bit weighed down by the detail about psychological interventions and the controversies surrounding them. In writing this short book the author has faced the basic problem of the bewildering complexity of autism and our collective difficulty in explaining, researching, and understanding disorders of human behaviour.