tbuckley/cabot-search huggingface dataset:
Abstract 1816: Attributable risks for hepatocellular carcinoma in the United States
Authors: Katherine A. McGlynn, Sabah Quraishi, Tania M. Welzel, Jessica A. Davila, Hashem B. El-Serag, Barry I. Graubard
Journal: Cancer Research (2010)

Abstract In the United States, known risk factors for hepatocellular carcinoma (HCC) include infection with the hepatitis B virus (HBV), infection with the hepatitis C virus (HCV), excess alcohol consumption, diabetes, obesity and several rare metabolic disorders (hemochromatosis, α-1 antitrypsin deficiency, porphyrias). The proportion of risk in the U.S. attributable to each factor separately, and to all factors together, however, is not well understood. To better quantify the risk attributable to these factors, logistic regression analysis was conducted using data from the SEER-Medicare linked database. All persons diagnosed with HCC (n=5,607), with at least 3 pre-diagnostic years of Medicare coverage between 1994 and 2005, were included as cases. A 5% random sample of persons residing in SEER locations (n=190,782) were included as controls. For each risk factor, odds ratios (OR) with their 95% confidence intervals (95%CI), and attributable risks (AR) with their 95%CI were calculated. In addition to calculating overall risks, risks were calculated after stratifying on race/ethnicity, gender and time period of HCC diagnosis. Among all individuals, the AR of all factors together was 63.3%. The AR among males, however, was higher than the AR among females (64.6% vs. 60.7%, respectively). By race/ethnicity, the AR of all factors together was highest among Asians (67.9%). This AR was followed by that among Hispanics (64.9%), then whites (63.3%) and finally, blacks (53.0%). Among specific factors, diabetes had the greatest AR at 34%, followed by alcohol-related conditions at 24.0%, HCV at 20.7%, HBV at 5.7%, metabolic disorders at 3.1% and obesity at 2.0%. These findings differed by gender and race/ethnicity, however. While diabetes had the highest AR among both males and females, the factor with the second highest AR among males was alcohol-related diseases, while among females; the factor with the second highest AR was HCV. The factors with the highest AR among each race/ethnic group were: whites - diabetes (36.4%) and alcohol-related disease (23.5%), blacks - HCV (31.9%) and alcohol-related disease (20.3%), Hispanics - alcohol-related disease (29.9%) and diabetes (28.0%), and Asians - HCV (31.7%) and diabetes (26.5%). These findings indicate that the current increase in incidence of HCC in the U.S. may be fueled by different factors in different racial/ethnic and gender groups. Overall, controlling diabetes might have a greater impact than any other single factor on reducing the incidence of HCC in the U.S. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1816.
Case 21-2012
Authors: Daniel P. Hunt, Anne E. Becker, Alexander R. Guimaraes, Anat Stemmer-Rachamimov, Joseph Misdraji
Journal: New England Journal of Medicine (2012)

A 27-year-old man was admitted to this hospital because of fatigue, myalgias, weakness, and profound weight loss. Marked abnormalities in liver function were noted, and chest imaging revealed pneumomediastinum. A diagnosis was made.
778 IMPROVED HBsAg LOSS RATE IN CHRONIC HEPATITIS B PATIENTS TREATED WITH PROLONGED PEGINTERFERON a-2a COMBINED WITH NUCLEOS(T)IDE ANALOGUE
Authors: S.Q. Wang, K.J. Xu, J.Z. Wu, T.T. Luongo, R.G. Yang, X.X. Geng, R.G. Huang, J.M. Lin, X.X. Yang, N. Jiang
Journal: Journal of Hepatology (2013)
Three-dimensional and endoscopic ultrasonography miniprobes in the pre-operative staging of rectal cancer
Authors: F Castro-Poças, P Lago, M Saraiva, E Santos, J Areias
Journal: Endoscopy (2006)

Introduction: Miniprobe (MP) EUS and threedimensional (3D) EUS are two new endo-rectal techniques that stand to not only replace conventional (conv) techniques but also improve staging (st) of rectal carcinoma (RC). Aims: carry out pre-operative evaluations of RC using EUS MP and 3D EUS and compare results with conv EUS assessments and pathological st. Material: 60 patients with RC studied. 3 types of equipment used for EUS: conv EUS (GF-UM20), 12MHz MP (UM-2R), and 3D EUS (Easy 3D Freescan). Comparisons among 3 techniques and between these and pathology results. Patients divided into 2 groups: those who had not undergone pre-operative adjuvant therapy and those who had. For first group we compared results obtained with MP and 3D imaging against conv EUS and pathology findings. With second group we compared results obtained with MP and 3D imaging against those obtained using conv EUS (gold standard). We verified if longi. or circu. extent of lesion had any influence on accuracy (ac) of the different techniques of T and N st. Results: T st, concordance (co) between MP and conv EUS was significant (K=0.81; p<0.001), as was co between 3D and conv EUS (K=0.87; p<0.001). Same was ascertained in co between pathology data and: conv EUS (K=0.81; p<0.001; ac 85.2%), MP EUS (K=0.76; p<0.001; ac 81.5%) and 3D EUS (K=0.95; p<0.001; ac 96.3%). N st, co between MP and conv EUS was significant (K=0.61; p<0.001), as was co between 3D and conv EUS (K=0.70; p<0.001). Same was ascertained in co between pathology data and: conv EUS (K=0.80; p<0.001; ac 90.5%, sensi 77.8%), MP EUS (K=0.59; p<0.003; ac 81%, sensi 55.6%) and 3D EUS (K=1; p<0.001; ac 100%, sensi 100%). Speci 100% for all 3 techniques. T and N st ac for the 3 techniques was not influenced by longi. or circu. extent of tumour. Conclusion: MP and 3D EUS proved to be valid in staging of RC. 3D EUS showed greater concordance with pathological st.
AB0816 Eliciting Patients' Preferences for Osteoporosis Drug Treatment: A Cross-European Discrete Choice Experiment
Authors: M. Hiligsmann, B. Dellaert, C. Dirksen, T. van der Weijden, V. Watson, S. Bours, S. Goemaere, J.-Y. Reginster, C. Roux, B. McGowan, C. Silke, B. Whelan, A. Diez-Perez, E. Torres, G. Papadakis, R. Rizzoli, C. Cooper, G. Pearson, A. Boonen
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The patient9s perspective is becoming increasingly important in clinical and policy decisions. Information about what patients prefer, and how they value various aspects of a health intervention can be useful when designing and evaluating health care programs and could help health professionals to improve disease management. <h3>Objectives</h3> To evaluate the preferences of European patients with, or at risk of, osteoporosis for medication attributes, and to establish how they trade between these attributes <h3>Methods</h3> A discrete choice experiment was conducted using a questionnaire in Belgium, France, Ireland, Spain, Switzerland and United Kingdom. Patients were asked to choose between two hypothetical unlabelled drug treatments (and an opt-out option) that vary in several attributes: efficacy in reducing the risk of fracture, type of potential common side-effects, mode and frequency of administration and out-of-pocket costs (only in countries with patients9 contribution on the cost of treatment). An efficient design was used to construct the treatment option choice sets and a mixed logit model was used to estimate patients9 preferences. <h3>Results</h3> A total of 1,124 patients completed the experiment, with at least 100 patients per country. As expected, in all countries, patients preferred treatment with higher effectiveness and lower cost was preferred in the three countries in which a cost-attribute was part of the experiment. In all countries, patients preferred 6-monthly subcutaneous injection over weekly oral tablets. In most countries, patients also preferred monthly oral tablet and yearly intravenous injections over weekly oral tablets. Patients disliked being at risk of gastro-intestinal disorders more than being at risk of skin reactions and flu-like symptoms. There were significant differences between countries for only some levels of attributes, and we found in all countries a significant variation in preferences across the sample for most attributes. <h3>Conclusions</h3> This study suggests that the preferences of patients for osteoporotic drug therapy did not substantially differ between six European countries. Only for levels of some attributes, significant differences were observed. The heterogeneity of preferences across each country highlights the potential importance of clinical decision-making taking individual preferences into account to improve osteoporosis care. <h3>Acknowledgements</h3> This study was funded by Amgen <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4055
In praise of Ecumenical Bayes
Authors: Michael D. Lee
Journal: Behavioral and Brain Sciences (2011)

Abstract Jones &amp; Love (J&amp;L) should have given more attention to Agnostic uses of Bayesian methods for the statistical analysis of models and data. Reliance on the frequentist analysis of Bayesian models has retarded their development and prevented their full evaluation. The Ecumenical integration of Bayesian statistics to analyze Bayesian models offers a better way to test their inferential and predictive capabilities.
Electron Probe Analysis for Iodine in Human Thyroid and Parathyroid Glands, Normal and Neoplastic&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: W G Banfield, P M Grimley, W G Hammond, C M Taylor, B DeFlorio, A J Tousimis
Journal: JNCI Journal of the National Cancer Institute (1971)

Iodine analysis in human thyroid and parathyroid tissue, normal and neopiastic, was performed using the electron probe X-ray microanalyzer. Iodine within the limit of detection, >0.04%, was found in the follicular colloid of normal thyroid and thyroid adenomas, but not in cells lining the follicles. Paraffin embedding and hematoxylin and eosin staining did not diminish the detectability. With one exception, there was no iodine in the colloid-like material or cells of parathyroid glands. There was none in parathyroid adenomas, the colloid or cells of thyroid carcinomas, or the amyloid or cells of medullary carcinoma of the thyroid.
Progressive elbow pain
Authors: Alexis Descatha, Thomas Despréaux, Ryan P Calfee, Bradley Evanoff, Olivier Saint-Lary
Journal: BMJ (2016)

#### What you need to know A 50 year old supermarket cashier complains of progressive elbow pain for the past two weeks. It is hard for her to scan heavy items at work and to lift saucepans at home. Lateral elbow pain is common (population prevalence 1-3%).1 It is usually assessed and managed in primary care, and the incidence of lateral elbow pain in general practice is 4-7/1000 people a year.2 Interrupted sleep, inability to use the hand, and psychological ill health (anxiety or depression) are associated with problems functioning at home or work. Ask questions to explore which structures in the elbow are likely to be affected.
ASSOCIATION OF CENTRAL AORTIC STIFFNESS AND NEUROHORMONAL FACTORS TO LEFT VENTRICULAR MECHANICAL FUNCTION IN HYPERTENSION: A STUDY WITH TWO DIMENSIONAL LAYER SPECIFIC SPECKLE TRACKING STRAIN IMAGING
Authors: Darae Kim, Chi Young Shim, Geu-Ru Hong, In Jeong Cho, Hyuk-Jae Chang, Jong-Won Ha, Namsik Chung
Journal: Journal of the American College of Cardiology (2016)
Abstract 5433: Prolonged histone hyperacetylation with a novel class of HDAC1/2 selective inhibitors
Authors: Joey L. Methot, Melissa Chenard, Close Joshua, Cruz Jonathan, William Dahlberg, Judith Fleming, Chris Hamblett, Hamill Julie, Paul Harrington, Andreas Harsch, Richard Heidebrecht, Bethany Hughes, Joon Jung, Candia Kenific, Astrid Kral, Richard Middleton, Nicole Ozerova, David Sloman, Matthew Stanton, Alexander Szewczak, Kevin Wilson, David Witter, Paul Secrist, Thomas Miller
Journal: Cancer Research (2010)

Abstract The histone deacetylase (HDAC) metalloenzymes are intricately involved in gene expression through epigenetic regulation of histone acetylation. They also regulate the acetylation status of numerous non-histone proteins such as transcription factors p53, STAT1 and NF-κB as well as α-tubulin, Hsp90 and Ku70. Of the eleven zinc-dependent HDAC enzymes identified, HDACs 1 and 2 appear to be most critical in oncogenesis and tumor maintenance. They are overexpressed in many human cancers and RNAi knockdown leads to increased apoptosis. We recently disclosed a family of novel HDAC1/HDAC2-selective biaryl inhibitors. In this presentation, we will describe unique features of these biaryl inhibitors that contribute to improved preclinical efficacy and tolerability. Desirable HDAC inhibitor properties identified from preclinical experience with Zolinza™ include subtype selectivity toward HDAC1/HDAC2 and prolonged target inhibition. Compelling in vitro and in vivo data indicates that solid tumor cell lines are most sensitive to HDAC inhibition under continuous exposure rather than intermittent exposure. These biaryl inhibitors exhibit extended target engagement in vivo, and are well tolerated in nude mice. Unlike other known HDAC inhibitors, these compounds exhibit a delay in and prolongation of histone hyperacetylation in nude mice bearing HCT116 tumors, extending beyond plasma clearance of the drug. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5433.
Tissue hyperplasia following placement of a biodegradable stent for a refractory esophageal stricture: treatment with argon plasma coagulation
Authors: F. Dumoulin, D. Plassmann
Journal: Endoscopy (2012)

A 36-year-old woman presented with high grade peptic stenosis in the distal esophagus ([Fig. 1]). After three consecutive sessions of steroid injection/dilation with disappointing results, a biodegradable polydioxanone esophageal stent (SX-Ella-BD, 25 × 80 mm; Ella-CS, r. s. o., Hradec Kràlové, Czech Republic) was inserted ([Fig. 2]). The patient experienced retrosternal pain for a short period of time after the intervention, but otherwise she had an uneventful recovery and was discharged 48 hours after the intervention. The patient was kept on high dose proton pump inhibitor treatment and had almost complete resolution of dysphagia. At 4 months after stent insertion the patient presented with recurrent dysphagia. A repeat endoscopy showed the partially degraded stent, with hyperplastic tissue at the proximal end, resulting in severe stenosis ([Fig. 3]). The stenosis was treated with argon plasma coagulation ([Fig. 4]). On follow-up endoscopy 10 months after stent insertion, the tissue hyperplasia had largely subsided ([Fig. 5 a]) and the stenosis had resolved completely ([Fig. 5 b]). The patient continues to remain symptom-free since over 18 months.
Indian editors urge medical council to rethink publication guidelines for academic promotions
Authors: Cheryl Travasso
Journal: BMJ (2016)

Members of the Indian Association of Medical Journal Editors have voiced their concerns about the Medical Council of India’s (MCI) current guidelines on academic promotions, which do not recognise e-journals as accepted publications, in a joint special editorial published in leading Indian journals.1

In India, promotion to associate professor and professor in medical colleges and institutions requires the candidate to publish at least two research articles, and the MCI issued an order in September 2015 to clearly define what constituted a research publication.2 It said that publication in e-journals (those without a print …
THU0020 Angiogenesis in Rheumatoid Arthritis: VEGF Expression in Synovial Fluid
Authors: L. Mas, V. Saurit, E. Cortiñas, E. Miretti, A. Alvarellos, T. Alvarellos
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The expansion of synovial epithelium in Rheumatoid Arthritis (RA), and the subsequent pannus invasion of underlying cartilage and bone, needs an increase in the vascular supply to the synovium. Angiogenesis is recognised as a key event in the formation and maintenance of the pannus in RA. The pro-angiogenic cytokine, vascular endothelial growth factor (VEGF), has been demonstrated to have a central involvement in the angiogenic process in RA. <h3>Objectives</h3> We evaluated gene expression levels of a set of genes associated with angiogenesis in Synovial Fluid (SF) from RA patients compared with osteoarthritis patients. <h3>Methods</h3> Knee SF samples were classified in two groups, Group I: RA with DAS 28 score &gt; 5.1, high disease activity (n=10, 7F/3M, age: 56,3 ± 20,9, range: 17-84) and Group II: Osteoarthritis (OA, n=18, 13F/5M, age: 70,5 ± 6,6, range: 58-86). Levels of gene expression of three genes previously associated with angiogenesis, including pro-angiogenic factors: VEGF and Angiopoietin 1 (ANGPT-1) and anti-angiogenic factor, Thrombospondin I (TSP1) were evaluated using Quantitative Real Time PCR (QPCR). All amplifications were carried out in duplicate and threshold cycle (C<sub>t</sub>) scores were averaged for calculations of relative expression values. The C<sub>t</sub> scores were normalized against C<sub>t</sub> scores by subtracting the corresponding β2Microglobuline (β2M) control, or ΔCt=C<sub>t,gene</sub>- C<sub>t,B2M</sub>. To test for differential gene expression between groups, a two sample t-test was performed to compare the ΔCt in the two groups. <h3>Results</h3> Gene expression level is showed in table 1. <h3>Conclusions</h3> In the present cross-sectional study, increased levels of VEGF and decreased levels of TSP-1 were observed in RA patients. These gene expression results might be associated with increased angiogenesis in RA patients with high disease activity. <h3>References</h3> Paleolog EM. Angiogenesis in rheumatoid arthritis. Supplement Review. Arthritis Res 2002, 4 (3): S81-S90. Afuwape AO et al. The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis. Histol Histopathol 2002, 17: 961-972. <h3>Disclosure of Interest</h3> None Declared
Abstract P6-09-05: Insulin Resistance, Diabetes Mellitus and Breast Cancer Risk in Pre-and Postmenopausal Women: Modification Effect by Moderate Physical Activity
Authors: G Torres-Mejía, A Ángeles-Llerenas, C Ortega-Olvera, E Lazcano-Ponce, I. Romieu
Journal: Cancer Research (2010)

Abstract Background It has been hypothesized that diabetes may influence the risk of breast cancer (BC) by impaired regulation of the insulin and insulin-like growth factors (IGF) pathways. Current evidence supports a reduction in BC risk by doing regular physical activity due, in part, by reducing insulin resistance and improving glucose control. Material and Methods A population based case control study was conducted to evaluate the association between insulin resistance and diabetes mellitus on the risk of BC in Mexican women. A total of 1000 incident cases and 1074 matched controls to cases by five years of age, site and health institution were analyzed. Women provided information on health, diet and physical activity by means of a face to face interview; information about the family history of diabetes mellitus and whether or not women were diagnosed with this disease. Anthropometric measurements and blood samples were obtained from all women. A conditional logistic regression model was used to assess this association. Results In postmenopausal women, there was an interaction between physical activity and diabetes mellitus on the risk of BC. The effect of diabetes mellitus type 2 decreased with increasing moderate physical activity (OR = 3.67, 95% CI 1.78 — 7.58; OR = 2.86, 95% CI 1.37 — 5.96; OR = 0.82, 95% CI 0.19 — 3.59, by increasing tertiles of daily hours of moderate physical activity respectively); in premenopausal women, this association was not statistically significant (OR = 1.55, 95% CI 0.86-2.79), however in a subsample of premenopausal women, an increase was observed in the risk of BC per unit change in the increase of C-peptide, an indirect marker of insulin resistance (OR = 1.98, 95% CI 1.41 - 2.76). Discussion The results of this study are consistent with numerous mechanisms linking physical activity directly to reduce BC risk probably, in part, through reducing insulin resistance and improving glucose control. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P6-09-05.
335 BCL-2 FAMILY MEMBER MCL-1 INTERACTS WITH THE P53 FAMILY OF TRANSCRIPTION FACTORS
Authors: M. Meinhard, L. Koenig, A. Pelc, A. Lovas, N. Joschko, H.H. Schulze-Bergkamen, W. Stremmel, M. Müller
Journal: Journal of Hepatology (2012)
Superimposed Double Parathyroid Adenoma on Tc-99m MIBI Imaging
Authors: I H Shon, P J Roach, E Bernard, G Fulcher, L Delbridge
Journal: Clinical Nuclear Medicine (2001)

HO SHON, IVAN M.B.B.S.*; ROACH, PAUL J. M.B.B.S., F.R.A.C.P.*§; BERNARD, ELIZABETH M.B.B.S., F.R.A.C.P.*§; FULCHER, GREGORY M.B.B.S., F.R.A.C.P.‡; DELBRIDGE, LEIGH M.D., F.R.A.C.S.† Author Information
Abstract P3-03-01: Minimal Residual Disease Monitoring in Breast Cancer Patients
Authors: V Mikulova, I Janatkova, M Cabinakova, P Tesarova, D Pavlista, K Kolostova, D Pinterova, M Romzova, V Rusnakova, M Kubista, T. Zima
Journal: Cancer Research (2010)

Abstract BACKGROUND: Breast cancer (BC) patients still harbor a considerable risk of metastatic relapse caused by minimal residual disease (MRD) despite of complete removal of primary tumor. The aim of this study was to identify single disseminated tumor cells (DTC) in the bone marrow and circulating tumor cells (CTC) in the peripheral blood as potential biomarkers for therapy response monitoring and metastatic relapse risk prediction. Finally, the gene expression profiles of CTCs have been analyzed. METHODS: A total of 87 patients with diagnosed BC at stage I to III and 115 metastatic patients were enrolled into a prospective study between years 2008 - 2010. Peripheral blood (5ml) for CTC-detection was collected from primary BC patients before chemotherapy (CHT), after 2 cycles of CHT and after the CHT. Metastatic BC patients have been examined for CTCs before starting a new line of the treatment. Bone marrow aspirates from 16 premenopausal BC patients (mean age 31) with primary tumor were analyzed for the presence of DTC by immunocytochemistry using the pan-cytokeratin antibody A45-B/B3 (Epimet™, AS Diagnostik, Germany) before surgery. CTC detection in blood was performed by AdnaTest BreastCancerTM(AdnaGen AG, Germany), which is based on the detection of EpCAM, HER2 and MUC1 specific transcripts in enriched CTC-lysates. cDNA from isolated CTCs has been further pre-amplified and used for multimarker qPCR gene expression profiling using Biomark® microfluidic 48x48 GE Dynamic arrays (Fluidigm, USA). qPCR results have been analyzed by GENEX vs. 5.2 software (MultiD Analysis). RESULTS: 286 CTC samples have been analyzed in total. The analysis has shown that the expression profiles of CTCs from primary BC patients have been significantly different comparing them to the CTC-profiles from metastatic BC patients for several of tested genes (e.g., CK19, GA7332, MLFIP1, SATB1, PTEN). Interestingly, before surgery of primary tumor DTCs were found in 5/16 patients (31 %) and CTCs in 7/16 (43 %). Both DTCs and CTCs together were found in 4/16 (25%) patients. In 18% of the primary BC patients no dissemination markers were found CONCLUSIONS: Information based on the CTCs-gene expression profiles could provide an additional support for therapy management. Metastatic potential of enriched CTCs will be further evaluated on the single cell level. This work has been supported by Grant Agency of Ministry of Health, Czech Republic (IGA NS9976) and Grant Agency of Charles University in Prague, Czech Republic no. 7709 and 59410. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-03-01.