tbuckley/cabot-search huggingface dataset:
Regulating firearm advertisements
Authors: F. A. Paola
Journal: JAMA (1997)

To the Editor.  —I disagree with the conclusion of Dr Vernick and colleagues 1 that regulating firearm advertisements may be an appropriate public health intervention. I do so principally because their argument is based on the alleged claim by firearm manufacturers that bringing a handgun into the home is   for the occupants of the home. As I read the advertisements depicted in their article, there was no such generally protective claim made, nor could one be reasonably inferred. It seems that the only claim that can reasonably be attributed to these advertisements is that if faced with an intruder, the homeowner is in a better position if armed than if unarmed.  Nor should too much be read into Colt's claim that  may be better to have [a handgun] and not need it, than to need [a handgun] and not have it [italics added]. 1 It may indeed. Let us accept
Case 35-1985
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Robert H. Ackerman, Edward P. Richardson
Journal: New England Journal of Medicine (1985)

Presentation of CaseA 30-year-old woman was admitted to the hospital because of progressive encephalopathy.There was a history of "migraine headaches" since childhood, with premenstrual exacerbations; the headaches improved when a hysterectomy was performed 10 months before entry because of dysmenorrhea and menorrhagia. Three years before admission there was the abrupt onset of a severe occipital headache with nausea and vomiting, for which she was seen at another hospital and treated with intramuscularly administered meperidine. She was otherwise well until three weeks before entry, when she experienced another severe occipital headache of abrupt onset, with nausea, vomiting, abdominal cramps, . . .
Patient and tumor characteristics to guarantee long-term survival following hepatic resection for hepatocellular carcinoma.
Authors: H. Iida, C. Yasui, T. Aihara, S. Ikuta, H. Yoshie, M. Tomomatsu, N. Beppu, H. Yanagi, N. Yamanaka
Journal: Journal of Clinical Oncology (2010)

e14578 Background: The Japanese guideline for the treatment of hepatocellular carcinoma (HCC) recommends resection for cases having three tumors or less with Child-Pugh classification A or B, and transcatheter arterial embolization (TAE) or hepatic arterial infusion (HAI) for multiple HCCs having four tumors or more. However, there are not a few long-term survivors who underwent resection for multiple HCCs. In this retrospective study, we determined the patients and tumors profile of long-term survivors following hepatic resection for multiple HCCs. Methods: Between January 2001 and May 2009, resection was performed for 397 HCC patients. Of those, 60 patients having four tumors or more were analyzed. Our study included 48 males and 12 females (mean age, 64.3 ± 9.5 years). The hepatitis virus HCV: HBV: HBV, HCV negative = 39: 12: 9. Child-Pugh classification A: B: C = 51: 9: 0. The number of tumors four: five: six or more = 24: 10: 26. The mean size of the longest tumor in diameter was 5.1 ± 4.7 cm. Twenty four patients underwent resection alone, while 36 underwent a combination therapy of resection and intraoperative ablation. Thirteen patients had residual tumors, while 47 had no residual tumors. The log-rank test was performed using the Kaplan-Meier method for univariate analysis. Multivariate analysis was performed using the Cox proportional hazards model. Results: Overall cumulative survival rates were 71.5% for one year, 49.2% for three year and 36.9% for five year. In the univariate analysis of tumor factors, maximum tumor size (cm) (5.0 < / ≥ 5.0), growth type (expansive growth/infiltrative growth), histrogical differentiation (well, moderate/poor), portal invasion (−/+), PIVKA-II (mAU/mL) (< 100/≥ 100), and Child- Pugh classification (A/B) affect survival rates significantly (p < 0.05). Also, in terms of operative factors, residual tumors (−/+) was found to significantly influence survival rates (p < 0.05). The multivariate analysis showed that prognostic factors were Child-Pugh classification (A/B), histrogical differentiation (well, moderate/poor) and residual tumors (−/+). Conclusions: Patients who could receive benefit from resection of multiple HCCs are as follows: liver function of Child-Pugh A, no residual tumors, and the main tumor is well or moderately differentiated HCC. No significant financial relationships to disclose.
Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes
Authors: Laura M. Jacobsen, Amanda L. Posgai, Martha Campbell-Thompson, Desmond A. Schatz
Journal: Diabetes Care (2016)

The review of organ donors’ medical history is often limited to the terminal hospitalization records. This 32-year-old Hispanic patient had a history of type 1 diabetes since age 13 years and was treated with insulin since diagnosis. However, we have reasons to challenge the clinical diagnosis. The HLA region provides the highest contribution to genetic risk for type 1 diabetes (2). Although the HLA profile observed for this patient is not known to be associated with either risk or protection (2,3), there has been a recent rise in type 1 diabetes incidence among patients with HLA considered to confer lower risk for developing the disease (4). The absence of type 1 diabetes–associated autoantibodies (i.e., glutamic acid decarboxylase, insulinoma-associated protein 2, zinc transporter 8) at the time of study may be attributable to autoantibody loss over time; the absence altogether has been reported in …
Studies of chain substitution caused sub-fibril level differences in stiffness and ultrastructure of wildtype and oim/oim collagen fibers using multifrequency-AFM and molecular modeling
Authors: Tao Li, Shu-Wei Chang, Naiara Rodriguez-Florez, Markus J. Buehler, Sandra Shefelbine, Ming Dao, Kaiyang Zeng
Journal: Biomaterials (2016)
The Appropriateness of Tympanostomy Tubes for Children-Reply
Authors: Jacqueline Kosecoff
Journal: JAMA (1995)

<h3>In Reply.</h3> —We are pleased to have generated discussion. We respond with general and specific comments. Length limitations make it impossible to address all concerns. Three of the authors are practicing physicians, and one (L.C.K.) provides primary pediatric care to inner-city children. Our purpose was to increase the appropriateness with which tympanostomy tubes are used and, thus, to improve the quality of care provided to children. The article does not discuss whether better use of watchful waiting and antibiotics will increase or decrease the cost of care. If it were to decrease the costs of care, then using this money to improve the access and quality of care to children would be consistent with what we have written.<sup>1-3</sup> Virtually none of the letters criticize the content of the criteria that were used in this study. This suggests implicit acceptance of their content validity. The recently released federal guideline for
Treatment With Clopidogrel After Myocardial Infarction—Reply
Authors: Charlotte Andersson, Gunnar H. Gislason, Christian Torp-Pedersen
Journal: JAMA (2012)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Синдром портальної гіпертензії: можливості сучасної діагностики
Authors: S.L. Меlanich, M.V. Chalyi
Journal: GASTROENTEROLOGY (2016)

У статті розглянуті можливості сучасної медицини в діагностиці синдрому портальної гіпертензії. Подані діагностичні критерії ультразвукових, ендоскопічних, рентгенологічних, ангіографічних і лабораторних методів в оцінці цього синдрому. Поєднане застосування декількох методів дослідження дозволяє диференціювати форму портальної гіпертензії, оцінити ступінь тяжкості та ризики розвитку її ускладнень.
Prescriber treatment patterns for tyrosine kinase inhibitors (TKI) and mammalian target of rapamycin (mTOR) inhibitors in patients with renal cell carcinoma.
Authors: Jim Montgomery, David Garofalo, Jason Drenning, Bruce A. Feinberg
Journal: Journal of Clinical Oncology (2015)

e17617 Background: Renal cell carcinoma represents a dynamic therapeutic area with multiple classes of treatments and several new agents on the horizon with novel mechanisms of action. Understanding current patterns of care in a real-world population may inform current sequential therapy decisions and provide context for the adoption of new therapeutics. We conducted a retrospective analysis evaluating prescriber treatment patterns for TKIs and mTOR inhibitors for patients with newly diagnosed and relapsed renal cell carcinoma. Methods: Using claims data (MORE2Registry), patients with renal cell carcinoma who started and completed at least one line of treatment with a TKI (sunitinib, pazopanib, axitinib, or sorafenib) and/or mTOR inhibitor (everolimus or temsirolimus) during the study period (January 2012 to February 2014) were identified by ICD9 code 189.0. Each patient’s treatment history was analyzed by line of therapy, defined as the line of therapy at disease progression or last regimen 90 days prior to date of data extraction (February 1, 2014). Results: Treatment histories for 917 unique patients with renal cell carcinoma were evaluated. Of these, 1240 separate lines of therapy were identified. Fifty-nine percent of all TKI use was in the first-line of therapy, whereas 89% of mTOR use was in the second- and third-lines of therapy. Conclusions: Our analysis lends support to prescriber behavior favoring TKIs as first-line treatment for renal cell carcinoma and mTOR inhibitors as second-or later line treatment. The low rate of mTOR use in first-line therapy raises concern for underutilization in high-risk patients. The adoption of emerging therapies may be based on challenging the accepted paradigm and prescriber comfort with TKI/TKI and TKI/mTOR inhibitor treatment sequence. TREATMENT GROUP No. of Patient LOT (n = 917) 1 LOT (n = 599) 2 LOT (n = 357) ≥ 3 LOT (n = 284) TKI 976 (100%) 59% 22% 20% mTOR 264 (100%) 10% 55% 34% Abbreviation: LOT, line(s) of therapy.
Treatment of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) relapsing after allogeneic hematopoietic cell transplantation (HCT).
Authors: A. Chiattone, B. Andersson, Q. Bashir, D. Landau, G. Rondon, Y. Nieto, G. Al Atrash, S. Giralt, R. E. Champlin, M. De Lima
Journal: Journal of Clinical Oncology (2010)

6539 Background: Disease relapse is a major cause of treatment failure after allogeneic HCT for AML and MDS. Therapeutic options after relapse are limited and the prognosis remains dismal. Methods: We analyzed 245 patients who received allogeneic HCT for MDS/AML using the conditioning regimen of fludarabine 40 mg/m2 and busulfan 130 mg/m2 for four days, between April 2001 and June 2008: 88 patients recurred. Results: Median age was 45 (range:18-66) years. Diagnosis was AML (n=72; 82%) or MDS (n=16; 18%). Donors were related (n=56) or unrelated (n=32). Relapse treatment: 21% (N=18) received supportive care only while 76% (N=67) received salvage (3 patients were lost to follow-up). Median complete remission (CR) duration after first HCT for the recurred group was 4 months; 67% of the patients relapsing <4 months received salvage treatment versus 90% of those that relapsed in >4 months (p=0.02). Salvage included: chemotherapy only (N=31), donor lymphocyte infusion (DLI) with or without chemotherapy (N=11), other (N=3), and second HCT with or without preceding salvage chemotherapy (n=22; 25%). Disease status at second HCT: CR2 (n=5) or active disease (n=17). Median survival after relapse was 3 months; 9 patients are alive (10%; 7 of 9 received second HCT. 2-year over all survival (OS) for second HCT and chemotherapy groups was 45% and 10%, respectively. Whereas 2-year OS was 0% for both DLI and supportive care only group. One-year OS was 45% (N=43) versus 10% (N=45) for patients whose post-transplant remission lasted >4 and <4 months, respectively (P=0.009). Conclusions: Survival after relapse is dictated primarily by post-transplant remission duration. A second HCT holds promise for long-term disease control in a subset of patients. 2-year OS 2-year OS Second allogeneic HCT 45% Chemotherapy 10% Donor lymphocyte infusion (DLI) 0% Supportive care only 0% CR duration after 1st HCT 1-year OS > 4 mo 45% < 4 mo 10% ü(p=0.009) No significant financial relationships to disclose.
Abstract 2163: Mapping SUMOylation sites of PTEN tumor suppressor
Authors: Yubing Wang, Chiwai Wong, Mingfei Yan, Penelope Or, Andrew M. Chan
Journal: Cancer Research (2015)

Abstract PTEN tumor suppressor plays crucial function in multiple cellular processes, including proliferation, migration, DNA repair, cell cycle and survival signaling. Its function is tightly controlled by a series of regulatory processes at transcriptional and post-translational levels. Small ubiquitin-related modifier (SUMO) is an essential post-transcriptional modifier which involves in many important biological functions. Previous studies showed that PTEN can be modified by SUMOylation on K254 and K266. SUMOylation on K254 controls the nuclear localization and retention of PTEN and plays essential role in DNA damage repair. On the contrary, SUMOylation on K266 is responsible for its membrane binding, which is required for the down-regulation of PI3K/AKT pathway. However, most studies mainly focus on SUMO1 modification, function of SUMO2/3 involved PTEN regulation is still unclear. In addition, the dynamic regulation and biological activities of different isoforms of SUMOylated PTEN in different subcellular compartments are not well-defined. Also, how PTEN phosphorylation impacted on PTEN SUMOylated have not been addressed fully. To address these questions, a series of PTEN SUMOylation defective-mutants targeted to different subcellular compartments were generated. In addition, a panel of phosphorylation sites mutants (T366A, S370A, S380A, T382A, T383A, and S385A) were included. These mutants were cotransfected with His-tagged SUMO1, SUMO2, and SUMO3 in 293T cells. SUMOylated PTEN protein species are affinity absorbed onto nickel columns. The characterization of these mutants will be discussed. To further delineate the dynamic regulation of SUMOylated PTEN, we are developing a BRET-based live cell imaging system by the ectopic co-expression of a HALO-tagged SUMO and NanoLuc-tagged PTEN expression constructs to monitor the subcellular localization of SUMO-conjugated PTEN in vivo. This work was supported by Hong Kong Research Grant Council (460713) and Hong Kong PhD Fellowship Scheme (PF-12-13876). Citation Format: Yubing Wang, Chiwai Wong, Mingfei Yan, Penelope Or, Andrew M. Chan. Mapping SUMOylation sites of PTEN tumor suppressor. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2163. doi:10.1158/1538-7445.AM2015-2163
Estimating State-Specific Contributions to PM <sub>2.5</sub> - and O <sub>3</sub> -Related Health Burden from Residential Combustion and Electricity Generating Unit Emissions in the United States
Authors: Stefani L. Penn, Saravanan Arunachalam, Matthew Woody, Wendy Heiger-Bernays, Yorghos Tripodis, Jonathan I. Levy
Journal: Environmental Health Perspectives (2016)

Residential combustion (RC) and electricity generating unit (EGU) emissions adversely impact air quality and human health by increasing ambient concentrations of fine particulate matter (PM2.5) and ozone (O3). Studies to date have not isolated contributing emissions by state of origin (source-state), which is necessary for policy makers to determine efficient strategies to decrease health impacts.In this study, we aimed to estimate health impacts (premature mortalities) attributable to PM2.5 and O3 from RC and EGU emissions by precursor species, source sector, and source-state in the continental United States for 2005.We used the Community Multiscale Air Quality model employing the decoupled direct method to quantify changes in air quality and epidemiological evidence to determine concentration-response functions to calculate associated health impacts.We estimated 21,000 premature mortalities per year from EGU emissions, driven by sulfur dioxide emissions forming PM2.5. More than half of EGU health impacts are attributable to emissions from eight states with significant coal combustion and large downwind populations. We estimate 10,000 premature mortalities per year from RC emissions, driven by primary PM2.5 emissions. States with large populations and significant residential wood combustion dominate RC health impacts. Annual mortality risk per thousand tons of precursor emissions (health damage functions) varied significantly across source-states for both source sectors and all precursor pollutants.Our findings reinforce the importance of pollutant-specific, location-specific, and source-specific models of health impacts in design of health-risk minimizing emissions control policies. Citation: Penn SL, Arunachalam S, Woody M, Heiger-Bernays W, Tripodis Y, Levy JI. 2017. Estimating state-specific contributions to PM2.5- and O3-related health burden from residential combustion and electricity generating unit emissions in the United States. Environ Health Perspect 125:324-332; http://dx.doi.org/10.1289/EHP550.
The lectin Siglec-G inhibits dendritic cell cross-presentation by impairing MHC class I–peptide complex formation
Authors: Yuanyuan Ding, Zhenhong Guo, Yiqi Liu, Xia Li, Qian Zhang, Xiongfei Xu, Yan Gu, Yi Zhang, Dezhi Zhao, Xuetao Cao
Journal: Nature Immunology (2016)
Estimating the Number of Pregnant Women Infected With Zika Virus and Expected Infants With Microcephaly Following the Zika Virus Outbreak in Puerto Rico, 2016
Authors: Sascha R. Ellington, Owen Devine, Jeanne Bertolli, Alma Martinez Quiñones, Carrie K. Shapiro-Mendoza, Janice Perez-Padilla, Brenda Rivera-Garcia, Regina M. Simeone, Denise J. Jamieson, Miguel Valencia-Prado, Suzanne M. Gilboa, Margaret A. Honein, Michael A. Johansson
Journal: JAMA Pediatrics (2016)

Zika virus (ZIKV) infection during pregnancy is a cause of congenital microcephaly and severe fetal brain defects, and it has been associated with other adverse pregnancy and birth outcomes.To estimate the number of pregnant women infected with ZIKV in Puerto Rico and the number of associated congenital microcephaly cases.We conducted a modeling study from April to July 2016. Using parameters derived from published reports, outcomes were modeled probabilistically using Monte Carlo simulation. We used uncertainty distributions to reflect the limited information available for parameter values. Given the high level of uncertainty in model parameters, interquartile ranges (IQRs) are presented as primary results. Outcomes were modeled for pregnant women in Puerto Rico, which currently has more confirmed ZIKV cases than any other US location.Zika virus infection in pregnant women.Number of pregnant women infected with ZIKV and number of congenital microcephaly cases.We estimated an IQR of 5900 to 10 300 pregnant women (median, 7800) might be infected during the initial ZIKV outbreak in Puerto Rico. Of these, an IQR of 100 to 270 infants (median, 180) may be born with microcephaly due to congenital ZIKV infection from mid-2016 to mid-2017. In the absence of a ZIKV outbreak, an IQR of 9 to 16 cases (median, 12) of congenital microcephaly are expected in Puerto Rico per year.The estimate of 5900 to 10 300 pregnant women that might be infected with ZIKV provides an estimate for the number of infants that could potentially have ZIKV-associated adverse outcomes. Including baseline cases of microcephaly, we estimated that an IQR of 110 to 290 total cases of congenital microcephaly, mostly attributable to ZIKV infection, could occur from mid-2016 to mid-2017 in the absence of effective interventions. The primary limitation in this analysis is uncertainty in model parameters. Multivariate sensitivity analyses indicated that the cumulative incidence of ZIKV infection and risk of microcephaly given maternal infection in the first trimester were the primary drivers of both magnitude and uncertainty in the estimated number of microcephaly cases. Increased information on these parameters would lead to more precise estimates. Nonetheless, the results underscore the need for urgent actions being undertaken in Puerto Rico to prevent congenital ZIKV infection and prepare for affected infants.
Pan-Aurora Kinases and TRAIL Combination Therapy Has Potent Antitumor Activity In Vivo Against Drug-Resistant Human Multiple Myeloma Xenograft Model
Authors: Paolo Lunghi, Laura Mazzera, Guerino Lombardi, Micaela Ricca, Manuela Abeltino, Davide Arienti, Anna Maria Cantoni, Attilio Corradi, Antonio Bonati
Journal: Blood (2011)
Acute encephalitis syndrome in Gorakhpur, Uttar Pradesh, India – Role of scrub typhus
Authors: Manoj V. Murhekar, Mahima Mittal, John Antony Jude Prakash, Vivekanandan M. Pillai, Mahim Mittal, C.P. Girish Kumar, Satish Shinde, Prashant Ranjan, Chinmay Oak, Nivedita Gupta, Sanjay Mehendale, Rashmi Arora, Mohan Gupte
Journal: Journal of Infection (2016)
O090 : Humanization of germ-free mice with alcoholic cirrhotic microbiota, but not healthy microbiota, induces bacterial translocation and a pro-inflammatory milieu, which is ameliorated with lactobacillus GG
Authors: D.J. Kang, P.B. Hylemon, R.B. Sartor, G. Kakiyama, P. Gillevet, D.M. Heuman, W.M. Pandak, J.M. Ridlon, O. Fiehn, D. Grapov, J.S. Bajaj
Journal: Journal of Hepatology (2015)
Pose à titre préventif de clips après mucosectomie pour lésions colorectales sessiles latéralement étendues : une analyse économique
Authors: G. Lesur
Journal: Endoscopy (2016)

La résection par mucosectomie de tumeurs colorectales latéralement étendues est un challenge. Le risque d’hémorragie est particulièrement élevé après ce type d’endoscopie thérapeutique, notamment en cas de localisation proximale dans le côlon. La pose de clips est parfois utilisée à titre préventif mais l’évaluation économique de cette attitude manque. L’hypothèse des auteurs est que cette prévention par clips est d’un bon rapport coût/efficacité pour les lésions du côlon droit.