tbuckley/cabot-search huggingface dataset:
1028 INCIDENCE AND RISK FACTORS OF RADIOEMBOLIZATION (RE)-INDUCED LIVER DISEASE: RESULTS OF GLOBAL THERAPEUTIC STRATEGY AIMING TO PREVENTION
Authors: B. Gil-Alzugaray, M. Iñarrairaegui, A. Benito, J.I. Bilbao, M. Rodriguez, D. D'Avola, I. Herrero, J. Quiroga, J. Prieto, B. Sangro
Journal: Journal of Hepatology (2012)
Abstract 4336: Macrophage migration inhibitory factor (MIF) plays roles in proliferation, survival and migration of Ewing tumor cells by activation of a CD74-CD44 receptor complex
Authors: Hyung-Gyoo Kang, Timothy J. Triche
Journal: Cancer Research (2012)

Abstract The deregulated expression of cytokines and the aberrant activation of their downstream signaling pathways would give tumor cells the abnormal proliferation and survival. Therefore identification and understanding of deregulated cytokines in certain tumor would provide an opportunity of better targeted therapies of the cancer. MIF, a proinflammatory cytokine has been known to play a role in proliferation, survival and apoptosis in several tumors. In our studies it was found that MIF expression in Ewing tumors is pretty high and it is secreted out of the cells. Ewing tumor cell lines deficient of MIF showed morphological change, deregulation of differentiation, decrease of proliferation and increase of apoptosis. Through the investigation of several signaling pathways it was found that JAK2/STATs pathways are involved in the MIF dependent survival and proliferation of Ewing tumors and in addition, MIF is involved in the autophagy of Ewing tumors through the activation of AMPK. It has been reported that CD74 is the main receptor of MIF and in our study it was found that CD74 is expressed in Ewing tumors even though the expression is much less than MIF. The decreased expression of CD74 in Ewing tumor cell lines caused the morphological change and inhibition of proliferation, which are the similar phenotypes of MIF deficient Ewing tumor cell lines. It is known that CD74 is associated with CD44 which is involved in the signaling pathways of cellular survival and proliferation. In our study it was found that decreased expression of CD44 in Ewing tumor cell lines caused the inhibition of cell survival and proliferation. In conclusion, our data implies that MIF and its downstream signaling pathways such as JAK/STATs, AMPK, CD74 and CD44 might be involved in growth, survival, proliferation and metastasis of Ewing tumors. Therefore MIF and its downstream signaling pathways could be promising targets of Ewing tumors therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4336. doi:1538-7445.AM2012-4336
PTU-227 Improving efficiency in capsule endoscopy: can reading times be reduced without sacrificing diagnostic accuracy? A self-assessment
Authors: M Nakamura, A Murino, A Fitzpatrick, C Fraser
Journal: Gut (2012)

<h3>Introduction</h3> Capsule endoscopy (CE) is a time consuming procedure. The RAPID 7 Access reading software (Given Imaging Ltd) has three patterns of view modes (VM) (one view, VM1; double views, VM2; quadruple views, VM4) and an adjustable frame rate (AFR) from 5 to 40 fps. The appropriate settings for VM and AFR depend on capsule endoscopist9s experience, and a consensus has not been achieved yet. The aim of this study was to investigate how different VM9s and AFR9s could influence diagnostic accuracy. <h3>Methods</h3> An entire capsule endoscopy procedure consisting of 27 small bowel angioectasias was selected from our database. This was read by a single expert capsule endoscopist repeatedly using 11 different randomised combinations of VM and AFR (1, 2 and 4 VM × 10, 15, 25 and 40 fps). Reading times and number of angioectasias detected for each combination were recorded and then compared. <h3>Results</h3> The small bowel transit time was 321 min. Mean reading times (all VM9s) at 10, 15, 25 and 40 fps respectively were 34, 22, 14 and 10 min. Considering 10 fps as the gold standard for reading, the reduction in reading time at 15, 25 and 40 fps was 33%, 60% and 70% respectively. No significant differences were noticed in reading times between VM9s at the same AFR. A mean of 23, 16, 7 and 6 angioectasias were detected at 10, 15, 25 and 40 fps respectively (all VM9s combined). Diagnostic accuracy at 25 and 40 fps was significantly lower than 10 fps (p=0.04, 0.01). The mean numbers of detected angioectasias according to VM were 14, 17 and 16 for VM1, VM2 and VM4 respectively. The lowest number of angioectasias (5) was detected using VM2 × 40 fps. The highest number of angioectasias (25) was detected using VM2 × 10 fps and VM4 × 10 fps. Using VM2 × 15 fps, 18 angioectasias were detected, meaning that diagnostic accuracy was reduced to 72% (compared with VM2 × 10 fps), although the reading time decreased by 33%. <h3>Conclusion</h3> Our findings suggest that the highest diagnostic accuracy was achieved with VM2 × 10 fps or VM4 × 10 fps. The AFR influences both diagnostic accuracy and reading time. As the AFR increases, reading times are reduced but this is associated with a reduction in diagnostic accuracy and a concomitant increase in miss rates. Capsule endoscopists need to be aware of this phenomenon. <h3>Competing interests</h3> None declared.
OP0094 Survival Benefit of Early Use of Cyclosporine in Dermatomyositis-Associated Interstitial Lung Disease
Authors: D.J. Go, E.H. Kang, J.K. Park, H.M. Kwon, Y.J. Lee, K.C. Shin, E.Y. Lee, Y.W. Song, E.B. Lee
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Interstitial lung disease (ILD) is the most common cause of mortality in patients with dermatomyositis (DM). Cyclosporine has been reported to improve clinical outcome in some patients with DM-associated ILD. <h3>Objectives</h3> To investigate the benefit of early introduction of cyclosporine on the survival of patients with DM-associated ILD. <h3>Methods</h3> All the patients with DM-associated ILD, who were treated with cyclosporine at Seoul National University Hospital (SNUH) and Seoul National University Bundang Hospital (SNUBH) between 1990 and 2013, were enrolled. Enrolled patients were diagnosed with DM according to Bohan-Peter9s classification criteria (n=28) or with clinically amyopathic dermatomyositis (CADM) according to Sontheimer9s classification criteria (n=19). ILD was diagnosed based on the typical findings on computed tomography (CT) and relevant respiratory symptoms or signs. Kaplan-Meier survival analysis was applied to compare overall mortality rates between patients who took cyclosporine as the initial treatment and those as the delayed treatment. Cox regression analysis was used to estimate the benefit of early treatment with cyclosporine after adjusting confounding characteristics. <h3>Results</h3> Among the 47 patients who were diagnosed with DM-associated ILD, 16 patients (34.04%) received cyclosprorine initially after diagnosis and 31 patients (65.96%) received cyclosporine after the trial of other immunosuppressants such as corticosteroids, cyclophosphamide or azathioprine. The mean time of follow-up was 43.57 person-years in initial treatment group and 76.23 person-years in delayed treatment group. The mortality rate was significantly lower in the initial treatment group than the delayed treatment group (0.02 person-years vs 0.18 person-years, p=0.0092 by log-rank test). The two groups did not differ in regard to age, sex, duration of disease, presence of autoantibodies, degree of dyspnea at initial visit, initial requirement of oxygen supplement, functional vital capacity (FVC) and diffusion capacity (DLCO) on pulmonary function test (PFT) and the presence of malignancy. Only the proportion of patients with CADM was higher in the initial treatment group than in the delayed treatment group (62.53% vs 29.03%, p=0.027). Survival benefit in the initial cyclosporine treatment remained significant even after adjusting for the CADM status (HR 0.075, 95% CI 0.009 - 0.603, p=0.015 by Cox-regression analysis). <h3>Conclusions</h3> This study showed significant survival benefit of initial cyclosporine treatment in patients with DM-associated ILD. A randomized controlled study is warranted to clearly demonstrate the therapeutic benefit of early use of cyclosporine in this potentially fatal disease. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3718
Contraceptives, Fat, Vitamins Debated at Prevention Forum
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Contraceptives, Fat, Vitamins Debated at Prevention Forum Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 20, 21 October 1992, Pages 1552–1554, https://doi.org/10.1093/jnci/84.20.1552 Published: 21 October 1992
NI-77 * SURGICAL TREATMENTS FOR LARGE AND GIANT MENINGIOMAS: EXPERIENCES WITH 35 CONSECUTIVE PATIENTS
Authors: J. Tong, H. Liu, L. Zhang, Y. Liu, J. Yuan, X. Zhang
Journal: Neuro-Oncology (2014)

INTRODUCTION: Resecting large and giant intracranial meningiomas can be challenging. Excellent surgical skills and rational surgical plans are very important for ideal tumor resections and less complications. We evaluated the use of three-dimensional computed tomographic angiography (3D-CTA) and rational reconstruction for the surgical removal of large and giant meningiomas in this study. METHODS: A retrospective review of 35 patients with large and giant meningiomas between Jan 2009 and Nov 2011 with a minimum follow-up of 12 months was studied. All the patients were operated by one neurosurgeon. More attentions were paid to the vessels protection during resection and reconstruction after resection. The average tumor volume was 92.94 cm3 (range 50-147cm3). 14 patients had 3D-CTA studies performed for diagnostic evaluation or preoperative planning and 21 patients had no 3D-CTA examinations. We analyzed the clinical data, radiological findings, surgical treatment, histology, blood testing result and outcome of patients. RESULTS: Gross tumour resection (GTR) was accomplished in 31(88.6%) patients, subtotal resection (STR) in 3(8.6%) patients and partial resection in 1 (2.9%) patient. One patient died five days after operation because of severe brain edema. Postoperative complications (cerebrospinal fluid leakage, quadriparesis) were observed in 3(8.6%) patients and no deficits were found before discharge. Postoperative radiation was administered to 7 of the 35 patients who had residual tumors or malignant meningiomas. Patients without preoperative 3D-CTA experienced a higher blood loss during the operation (822.7ml compared with 466.7ml) (p = 0.095) and had a lower HGB level compared with patients with 3D-CTA(98.3g/l compared with 114.6g/l) (p = 0.046). CONCLUSIONS: The findings of this study suggested that preoperative 3D-CTA has great benefits for the operative bleeding control and adjacent vessels protections. Rational reconstructions after resections are very important for avoiding complications for large and giant meningiomas surgeries.
P710Differential regulation of vascular calcification by neutral and acid sphingomyelinases
Authors: TG Morris, C Wilson, V Ohanian, AE Canfield, J Ohanian
Journal: Cardiovascular Research (2014)

Vascular calcification is the formation of mineralised tissue within the walls of arteries and is associated with increased cardiovascular mortality. The pathology involves the osteogenic differentiation of vascular smooth muscle cells (VSMCs) and matrix mineralisation. The development of vascular calcification has many similarities to bone formation; although the exact mechanisms are not fully understood. Recent studies have demonstrated that the bioactive sphingolipid, ceramide, is required for normal bone formation and development. The levels of ceramide are controlled by secretory and lysosomal acid sphingomyelinases (aSMase) and the plasma membrane-located neutral sphingomyelinase (nSMase). Our aim was to investigate whether ceramide and sphingomyelinases are involved in VSMC matrix mineralisation. Bovine aortic VSMCs were cultured ± elevated phosphate to induce osteogenic differentiation and matrix mineralisation. Osteogenic differentiation was confirmed by downregulation of VSMC markers (αSMA, SM22α) and upregulation of osteogenic markers (Runx2, Msx2). Matrix mineralisation was detected using alizarin red and quantified by dye elution. mRNA expression of sphingomyelinases were quantified by Q-PCR and activity changes were determined using a fluorescent in vitro assay. Mass spectroscopy was used to investigate changes in ceramide species. nSMase activity was inhibited by GW4869 (1-10 μM) and lysosomal aSMase activity was inhibited by desipramine (1-10 μM). Q-PCR demonstrated that at the onset of matrix mineralisation and osteogenic differentiation the mRNA expression of nSMase 1 and 3 increased two-fold (P<0.05); no changes in aSMase expression were detected. The activity of both nSMase and lysosmal aSMase significantly increased (P<0.05) at the onset of matrix mineralisation. Mass spectroscopy revealed that the levels of C14, C18 and C20 ceramide species increased during matrix mineralisation. Inhibition of nSMase activity with GW4869 significantly increased matrix mineralisation in a dose-dependent manner (1 μM P<0.05; 10 μM P<0.01). Conversely, the inhibition of lysosomal aSMase with desipramine completely prevented matrix mineralisation (P<0.01). These data demonstrate for the first time that sphingomyelinases modulate VSMC matrix mineralisation. The pharmacological inhibition of sphingomyelinases has shown that nSMase is an inhibitor of VSMC matrix mineralisation, whereas lysosmal aSMase is a promoter. Collectively, these findings suggest that the sphingomyelinase-regulated production of ceramide in different sub-cellular locations may differentially regulate vascular calcification.
Antivimentin Autoantibodies in Angioimmunoblastic Lymphadenopathy
Authors: Koussay Dellagi, Jean-Claude Brouet, Maxime Seligmann
Journal: New England Journal of Medicine (1984)

We evaluated the prevalence and specificity of smooth-muscle autoantibodies in 20 serum samples obtained from patients with angioimmunoblastic lymphadenopathy. Smooth-muscle antibodies in high titers were detected in 75 per cent of the samples. No such antibodies were found in 30 normal control serum samples or in 10 samples from patients with non-Hodgkin's lymphoma and 1 of 12 from patients with other types of polyclonal hypergammaglobulinemia were positive. The antibodies were polyclonal and belonged to the IgM, IgG, and IgA classes. They reacted with vimentin, the major polypeptide of the intermediate-filament cytoskeleton of mesenchymal cells. The pattern of tissue reactivity and absorption experiments both show that these antibodies recognize special antigenic determinants of the vimentin polypeptide that are shared by vimentin and other classes of intermediate-filament proteins - namely, keratin and desmin. The frequency of this unusual autoantibody activity in angioimmunoblastic lymphadenopathy suggests that, like hypergammaglobulinemia and a positive Coombs' test, it may represent a useful serologic marker for the disease.
AB0260 Cutaneous rheumatoid vasculitis: still a challenge
Authors: T. Pamplona, K. Bonfiglioli, L. Quedes, D. Domiciniano, A. C. Medeiros, C. R. Gonçalves, I. M. M. Laurindo
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> A decrease in rheumatoid vasculitis (RV) has been recently reported, particularly cutaneous vasculitis. However, we have observed otherwise: new cases, relapses and cases refractory to treatment, despite the use of new biologic medications. <h3>Objectives</h3> Objective: to study frequency, relapses, medication and response to treatment of rheumatoid cutaneous vasculitis in patients from a unique center and in long term follow-up. <h3>Methods</h3> Methods – all cases of cutaneous vasculitis observed in a cohort of RA(ACR1987) patients 12-70 years old, in regular follow up (7600 patients/years of observation) in our center were included. Demographic data, smoking status, co-morbidities, disease activity, medication in use at the vasculitis onset and remission were recorded. All cases of nailfold vasculitis (small vases) and deep cutaneous ulcers and ischemia (medium vases) were included. Malleolar and/or perimalleolar ulcers were excluded <h3>Results</h3> Results – 30 episodes were observed in 22 patients; most females (91%), mean age 57(11.6)yrs, mean disese duration 23(11.6)yrs. Regarding auto-antibodies, 96%were RF positive and 61% presented ANA positive but without any specific pattern or specific antibody. In 41% small vase vasculitis was detected (nailfold lesions and purpura) and in 59% medium vase vasculites (deep cutaneous ulcers and ischemia); no patient presented involvement of both small and of medium vases. No difference was observed regarding demographic data, disease duration, co morbidities or disease activity between patients with nailfold vasculitis or cutaneous ulcers. Medications in use at the beginning of the vasculitis were also similar, most patients being on DMARDS although one patient developed nailfold vasculitis while in use of infliximab and etanercept and one presented cutaneous ulcers using infliximab. The response to treatment was also variable, with similar number of patients using biologic agents due o non response to traditional therapy. Duration of each vasculitis episode was widely variable, since prompt response and relapse to long duration refractory to theraphy. Interesting that most cases developed during disease activity (76%), contrarily to the classical descriptions. Also, of note, the distribution of cases during follow up, with an increased number in recent years (2000-2005= 10 cases, 2006-2012=16cases) <h3>Conclusions</h3> Conclusion –A reduction in rheumatoid vasculitis cases was not observed in our population as well as a consistent response to new biologic agents. It seens an area with unmet needs. <h3>Disclosure of Interest</h3> None Declared
Caesarean section rates: Evaluate the reasons for surgery
Authors: C R Leitch, J J Walker
Journal: BMJ (1994)

There is evidence that prophylactic penicillin is effective in children with sickle cell disease, and it seems sensible to give similar prophylaxis to hyposplenic patients with other diseases.Identifying such patients is now relatively easy with the method of counting pitted red cells under differen- tial interference contrast microscopy.The risks of fulminant sepsis in patients who may be hypo- splenic must be borne in mind, and such patients should be treated promptly with antibiotics when they become febrile.At present there is insufficient evidence to justify giving pneumococcal vaccine to all patients who may be hyposplenic.Nevertheless, it seems prudent to vaccinate certain high risk groups such as children with sickle cell disease and patients with severe extensive chronic inflammatory bowel disease.
Dependent Coverage and Use of Preventive Care under the Affordable Care Act
Authors: Xuesong Han, K Robin Yabroff, Anthony S Robbins, Zhiyuan Zheng, Ahmedin Jemal
Journal: New England Journal of Medicine (2014)

To the Editor: Since it officially went into effect on September 23, 2010, dependent-coverage expansion under the Affordable Care Act (ACA), which allows young adults to be covered under a parent's health insurance plan until they turn 26 years of age, has substantially improved the insurance coverage of persons between the ages of 19 and 25 years.1–4 However, it is unknown whether dependent-coverage expansion has improved the use of recommended preventive services in this age group. Using data from household interviews obtained in the nationally representative Medical Expenditure Panel Survey in the United States, we examined the use of . . .
Quality Assurance Issues
Authors: Judy Homa-Lowry
Journal: Diabetes Care (1992)

Since 1965, when the Medicare and Medicaid programs were established by amendments to the Social Security Act, there has been an evolution from internal utilization review of hospital care to internal and external review of quality assurance. Hospitalizations for diabetes as a primary diagnosis have decreased over this period, suggesting that more diabetes care is delivered as outpatient care and is therefore not subject to quality assurance review. Although it is difficult to discern the effect of quality assurance programs and case management on the quality of diabetes care, it is certain that these programs will have a major influence in the future.
SEGUIMIENTO A LARGO PLAZO DE LOS ENFERMOS CON CÁPSULA ENDOSCÓPICA NORMAL, ¿SE LLEGA A UN DIAGNÓSTICOS DEFINITIVO?
Authors: N Alcaide, B Velayos, R Aller, L Fernández, G González, E Berroa, C Tafur, S Gómez, L Ruiz, L Del Olmo, JM González
Journal: Endoscopy (2014)

Introducción: Es poco conocido el impacto de un resultado negativo tras la realización de una cápsula endoscópica (CE).
ECHOCARDIOGRAPHICALLY MEASURED EPICARDIAL FAT PREDICTS RESTENOSIS AFTER CORONARY STENTING IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFARCTION
Authors: Jin-Sun Park, You-Hong Lee, Kyoung Woo Seo, Byoung-Joo Choi, So-Yeon Choi, Myeong-Ho Yoon, Gyo-Seung Hwang, Seung Jea Tahk, Joon-Han Shin
Journal: Journal of the American College of Cardiology (2016)
P1190 MODELING THE IMPACT OF EARLY ANTIRETROVIRAL THERAPY FOR ADULTS COINFECTED WITH HIV AND HEPATITIS B OR C IN SOUTH AFRICA
Authors: N.K. Martin, A. Devine, J.W. Eaton, T.B. Hallett, G.R. Foster, G.J. Dore, P.J. Easterbrook, R. Legood, P. Vickerman
Journal: Journal of Hepatology (2014)
DEMOGRAPHIC DIFFERENCES IN THE INTERVENTIONAL THERAPY OF ACUTE AORTIC DISSECTION
Authors: Uchenna C. Okoro, Ali Khoynezhad, Marek Ehrlich, Mark Peterson, Anil Bhan, Himanshu Patel, Truls Myrmel, Thomas Gleason, Marco Di Eusanio, Lori Conklin, Khaled Abdul-Nour, Nathaniel I. Costin, Daniel Montgomery, Teng Lee, Eric Isselbacher, Christoph A. Nienaber, Eduardo Bossone
Journal: Journal of the American College of Cardiology (2016)