tbuckley/cabot-search huggingface dataset:
Stage A1 Prostate Cancer: Follow-Up with Digital Rectal Exploration, Prostate Markers, Fine-Needle Aspiration, Ultrasonographically Guided Needle Biopsy and Biopsies of the Residual Prostate with Resectoscope
Authors: G Breda, P Silvestre, A Giunta, D Xausa, A Tamai, L Gherardi
Journal: European Urology (1994)
Increased Platelet Thrombus Formation Under Flow Condition In Myeloproliferative Neoplasms (MPN)
Authors: Alfonso Vignoli, Paola van der Meijden, Marina Marchetti, Cinzia Giaccherini, Serena Tessarolo, Frauke Swieringa, Hugo ten Cate, Guido Finazzi, Alessandro Rambaldi, Johan Heemskerk, Anna Falanga
Journal: Blood (2013)
The usefulness of analysis of survival by tumor response.
Authors: P Selby, T McElwain
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.9.1421 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3746381 The usefulness of analysis of survival by tumor response. P SelbyxP SelbySearch for articles by this author , T McElwainxT McElwainSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.9.1421 PDF "The usefulness of analysis of survival by tumor response.." Journal of Clinical Oncology, 4(9), pp. 1421–1422© 1986 by American Society of Clinical Oncology
The R Protein of SARS-CoV: Analyses of Structure and Function Based on Four Complete Genome Sequences of Isolates BJ01-BJ04
Authors: Zuyuan Xu, Haiqing Zhang, Xiangjun Tian, Jia Ji, Wei Li, Yan Li, Wei Tian, Yujun Han, Lili Wang, Zizhang Zhang, Jing Xu, Wei Wei, Jingui Zhu, Haiyan Sun, Xiaowei Zhang, Jun Zhou, Songgang Li, Jun Wang, Jian Wang, Shengli Bi, Huanming Yang
Journal: Genomics Proteomics & Bioinformatics (2003)

Abstract The R (replicase) protein is the uniquely defined non-structural protein (NSP) responsible for RNA replication, mutation rate or fidelity, regulation of transcription in coronaviruses and many other ssRNA viruses. Based on our complete genome sequences of four isolates (BJ01-BJ04) of SARS-CoV from Beijing, China, we analyzed the structure and predicted functions of the R protein in comparison with 13 other isolates of SARS-CoV and 6 other coronaviruses. The entire ORF (open-reading frame) encodes for two major enzyme activities, RNA-dependent RNA polymerase (RdRp) and proteinase activities. The R polyprotein undergoes a complex proteolytic process to produce 15 function-related peptides. A hydrophobic domain (HOD) and a hydrophilic domain (HID) are newly identified within NSP1. The substitution rate of the R protein is close to the average of the SARS-CoV genome. The functional domains in all NSPs of the R protein give different phylogenetic results that suggest their different mutation rate under selective pressure. Eleven highly conserved regions in RdRp and twelve cleavage sites by 3CLP (chymotrypsin-like protein) have been identified as potential drug targets. Findings suggest that it is possible to obtain information about the phylogeny of SARS-CoV, as well as potential tools for drug design, genotyping and diagnostics of SARS.
Concurrent G-CSF and chemotherapy.
Authors: R B Livingston
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.12.3917 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9850040 Concurrent G-CSF and chemotherapy. R B LivingstonxR B LivingstonSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.12.3917 First Page PDF © 1998 by American Society of Clinical Oncology
Prognosis of Adults With Borderline Left Ventricular Ejection Fraction
Authors: Connie W. Tsao, Asya Lyass, Martin G. Larson, Susan Cheng, Carolyn S.P. Lam, Jayashri R. Aragam, Emelia J. Benjamin, Ramachandran S. Vasan
Journal: JACC Heart Failure (2016)
Life events and early and late onset of bipolar disorder
Authors: B Glassner, C V Haldipur
Journal: American Journal of Psychiatry (1983)

Forty-six subjects with bipolar disorder and their relatives and friends were interviewed in depth about life events preceding the first and the latest episode of the subject's affective illness. Twenty years of age was the cutting point for dividing the sample into early- and late-onset groups. The late-onset group reported the occurrence of significantly more stressful life events before the first and before the latest episode of affective illness than the early-onset group did.
Infantile haemangiomas do not occur more frequently in children with congenital melanocytic naevi
Authors: V. Martins da Silva, V. Kinsler
Journal: British Journal of Dermatology (2016)

Infantile Haemangioma (IH) is a very common benign vascular tumour with a reported incidence of 4-10% in infants1, and no clear genetic basis described as yet2. Congenital melanocytic nevi (CMN) are benign melanocytic tumours present in 1% of newborns, which when multiple are caused by post-zygotic mutations in the gene NRAS in the majority of cases3, and where single carry various somatic mutations where causality is difficult to prove4–6. Melanocytic and vascular birthmarks can co-exist in the condition Phakomatosis pigmentovascularis, and the same genetic mutation is responsible for both cutaneous lesions7, however these do not involve either CMN or IH. Moreover, the vascular lesion in PPV is considered congenital and malformative as CMN, and not proliferative and acquired as IH8. A case series of six patients presenting with both CMN and IH has previously been reported, where the authors hypothesised that this co-occurrence might be more common than expected by chance9.

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Delineation of the dendritic cell lineage by generating large numbers of Birbeck granule-positive Langerhans cells from human peripheral blood progenitor cells in vitro
Authors: A Mackensen, B Herbst, G Kohler, G Wolff-Vorbeck, FM Rosenthal, H Veelken, P Kulmburg, HE Schaefer, R Mertelsmann, A Lindemann
Journal: Blood (1995)
Colonoscopy through appendectomy in a colonic stenosis
Authors: Fernando Sábado, Jesús Nomdedeu, Pablo Aragó, Daniel Ahicart, Beatriz Castelló, Antonio Peris
Journal: Endoscopy (2015)

Colonoscopy is the standard method used for exploring the colon to remove polyps. However, a percentage of the colonoscopic procedures performed cannot be completed for various reasons, such as the presence of a stenosis [1] [2]. Computed tomographic colonography has proved to be very useful in cases in which a colonoscopy cannot be completed, but a drawback is that therapy is not possible [3].
A Unified Exact Approach for Knapsack Problems with Side Constraints
Authors: Federico Della Croce, Fabio Guido Mario Salassa, Rosario Scatamacchia
Journal: Eurosurveillance (2015)

We propose a uniﬁed exact approach for two different generalizations of the 0-1 Knapsack problem, that is the 0-1 Knapsack Problem with Setups and the 0-1 Collapsing Knapsack Problem. In the ﬁrst problem, the items belong to disjoint families (or classes) and they can be picked only if the corresponding family is activated. The selection of a class involves setup costs and resource consumptions thus affecting both the objective function and the capacity constraint. In the 0-1 Collapsing Knapsack Problem the capacity of the knapsack is not a scalar but a non-increasing function of the number of items included, namely it is inversely related to the number of items placed inside the knapsack. The uniﬁed approach involves three main steps and relies on an effective exploration of a speciﬁc set of variables that leads to solve standard knapsack problems. It proves to be very effective both on the 0-1 Knapsack Problem with Setups and on the 0-1 Collapsing Knapsack Problem and is capable of solving to optimality large size instances with limited computational effort. The method signiﬁcantly outperforms the state of art solver CPLEX 12.5 and compares favorably to the algorithms available in literature
The Relative Oxygen Affinity of Human and of Vegetal Phenoloxidase&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Kertész, Denis
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article The Relative Oxygen Affinity of Human and of Vegetal Phenoloxidase Get access Denis Kertész Denis Kertész Research Department, Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 5, April 1954, Pages 1093–1098, https://doi.org/10.1093/jnci/14.5.1093 Published: 01 April 1954 Article history Received: 27 July 1953 Published: 01 April 1954
Endoscopic intraluminal cutting technique for indwelling devices using a lithotripter handle and guidewire
Authors: Yu Muta, Yoshihiro Nishikawa, Kotaro Watanabe, Koichiro Kawano, Hiroshi Seno, Tsutomu Chiba, Shujiro Yazumi
Journal: Endoscopy (2015)

Many transmural endoscopic devices have been developed for various different procedures; however, few options exist to endoscopically process these indwelling devices once they have been positioned. Here, we introduce a novel technique that allows indwelling devices to be cut endoscopically using a combination of an endoscopic retrograde cholangiopancreatography (ERCP) lithotripter handle and a guidewire, as illustrated in these two patients.
Abstract 76: Molecular profiling of AML patient derived xenograft models with deep sequencing using a 109 AML associated gene panel and a 409 gene comprehensive cancer panel
Authors: Stephen Huang, Paul Lira, Kai Wang, Cathy Zhang, Amy Jackson-Fisher, Keith Ching, Paul Rejto
Journal: Cancer Research (2015)

Abstract We have developed and validated a 109 AML associated gene panel NGS assay based on sequence capture technologies. The overall assay sensitivity was 99.%, and overall assay specificity was 100% when sequenced with reference “gold” standard NA12878. Assay analytical accuracy was evaluated with diluted cell line samples harboring mutations in this gene panel, all diluted mutations with minor allele frequencies were detected, analytical limit of detection (LOD) is &amp;lt; 5%, and assay reproducibility is 96.8%. The assay also demonstrated robustness in sequencing 10 commercial AML patient samples (whole blood and bone marrow) and detecting mutations. Therefore, the AML gene panel deep sequencing assay is sensitive and accurate and is ready to be used for preclinical and clinical studies. We subsequently sequenced 15 AML patient derived xenograft (PDX) models with this assay. These models were also deep sequenced with a 409 comprehensive cancer gene panel based on multiplex amplicon technologies. The mutation profiles of each model will be summarized in this presentation using two sequencing platforms. By analysis of the mutation profile of each model, sub-clones of mutations were revealed in the early passages of these models. Two of these models with FLT-3 mutations were later treated with Quizartinib and Crenolanib separately, the treated mouse models were profiled with these two targeted gene panels; clonal evolution of mutations in these models treated with FLT-3 inhibitors was documented. Deep sequencing with target gene panel is a powerful tool to decipher the mutation sub-clones in the early passages of PDX models, and understand the acquired resistance of drug treatment. Citation Format: Stephen Huang, Paul Lira, Kai Wang, Cathy Zhang, Amy Jackson-Fisher, Keith Ching, Paul Rejto. Molecular profiling of AML patient derived xenograft models with deep sequencing using a 109 AML associated gene panel and a 409 gene comprehensive cancer panel. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 76. doi:10.1158/1538-7445.AM2015-76
Neurotropic Effect of 7,12-Dimethylbenz[a]anthracene in Transplacental Carcinogenesis
Authors: Nikolai P. Napalkov, Valeri A. Alexandrov
Journal: JNCI Journal of the National Cancer Institute (1974)

Single intravenous injection of 15 mg/kg 7,12-dimethylbenz[a]anthracene into pregnant rats on day 21 after conception caused numerous tumors in their offspring. In 14 of 21 offspring, the transplacentally induced tumors were neurogenic. These data suggested that, in transplacental carcinogenesis, a tropism could occur which was not inherent in the effect of a given carcinogen in postnatal life.
SP0241 Extracellular Vesicles in Rheumatic Diseases
Authors: G. Nagy
Journal: Annals of the Rheumatic Diseases (2015)

Extracellular vesicles (EVs) including microvesicles, apoptotic bodies and exosomes are regarded as a crucial form of intercellular communication. EVs are present in body fluids, may carry proteins, lipids, RNA, microRNA and DNA between cells. In addition to their widely studied physiological roles, EVs represent a promising and rapidly growing research field in inflammatory diseases, including rheumatologic conditions. Several lines of evidence support the role of synovial and blood EVs in the pathogenesis of rheumatoid arthritis (RA). Platelet derived microvesicles may carry proinflammatory cytokines in the inflamed synovium in RA. Recent data also indicate the possible role of EVs in the pathogenesis of systemic lupus erythematosus, systemic sclerosis and juvenile idiopathic arthritis. EVs may serve as biomarkers and may represent therapeutic targets in inflammatory conditions. <h3>Disclosure of Interest</h3> None declared
IgG4 but no IgG1 antibody production after intralymphatic immunotherapy with recombinant <scp>MAT</scp>‐Feld1 in human
Authors: S. N. Freiberger, M. Zehnder, G. Gafvelin, H. Grönlund, T. M. Kündig, P. Johansen
Journal: Allergy (2016)

Abstract Allergy immunotherapy ( AIT ) mediates protection against allergen exposure in part due to allergen‐specific antibodies. While immunization typically stimulated IgG1 and IgG2, AIT is often associated with production of IgG4. Here, twenty cat dander‐sensitized patients were randomized to receive three injections of intralymphatic immunotherapy ( ILIT ) with MAT ‐Feld1 adsorbed to aluminum hydroxide or just aluminum hydroxide (placebo) in a double‐blind setting (ClinicalTrials.gov NCT 00718679). Whereas the clinical data, showing benefit of Mat‐Feld1 ILIT was published in 2012 (Senti et al., J Allergy Clin Immunol, vol 129(5):1290–1296), the current study investigated the cat allergen‐specific antibody responses. Blood was drawn prior to ILIT , as well as 1, 3, and 12 months after first ILIT . The sera were analyzed to characterize all IgG subclasses and IgE antibody responses. ILIT with MAT ‐Feld1 elicited high levels of total IgG that were maintained for at least 12 months. Interestingly, a strong increase in IgG4 and some increase in IgG2 were observed throughout the study, while production of cat‐specific IgG1 and IgG3 was not stimulated by MAT ‐Feld1 ILIT . The IgE levels remained constant.
Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer
Authors: Duane H. Hamilton, Lesley Mathews Griner, Jonathan M. Keller, Xin Hu, Noel Southall, Juan Marugan, Justin M. David, Marc Ferrer, Claudia Palena
Journal: Clinical Cancer Research (2016)

The conversion of tumor cells from an epithelial to a mesenchymal-like phenotype, via a process designated as the epithelial-mesenchymal transition (EMT), is known to mediate tumor resistance to a variety of cell death inducers, including cytotoxic effector immune cells. The goal of this study was to identify and potentially repurpose FDA-approved compounds capable of reducing mesenchymal features of human lung carcinoma cells, which could be used in combination with immunotherapies or chemotherapeutic strategies to improve clinical responses.In the current report, we have utilized a quantitative high-throughput screening (qHTS) of a pharmaceutical collection of more than 2,000 compounds to identify clinically approved drugs capable of augmenting the sensitivity of mesenchymal-like, lung cancer cells to immune- and chemotherapy-mediated lysis, both in vitro and in vivo RESULTS: The estrogen receptor antagonist fulvestrant was shown to reduce mesenchymal features of lung carcinoma cells, resulting in tumor sensitization to the cytotoxic effect of antigen-specific T cells, natural killer (NK) effector cells, and chemotherapy both in vivo and in vitro CONCLUSIONS: To our knowledge, this is the first report defining a potential role for estrogenic signaling in promoting tumor resistance to immune-mediated cytotoxicity and chemotherapy in lung cancer. Our data demonstrate a robust association between the acquisition of mesenchymal attributes, therapeutic resistance of lung carcinoma cells, and the expression of estrogen receptor 1 (ESR1), supporting further investigations on the role of estrogen signaling in lung cancer progression via the induction of EMT. Clin Cancer Res; 22(24); 6204-16. ©2016 AACR.
l-Alpha-acetylmethadol (LAAM): prognostic considerations
Authors: R B Resnick, L Orlin, G Geyer, E Schuyten-Resnick, R S Kestenbaum, A M Freedman
Journal: American Journal of Psychiatry (1976)

The authors studied the responses of 28 adult male volunteers who were openly changed from methadone to l-alpha-acetylmethadol (LAAM) maintenance. They found that patients who had been receiving middle-range doses (50-70 mg) of methadone required a significantly lower mean increase in LAAM than patients who had been receiving either high or low methadone doses and that the patients who accepted LAAM differed significantly from those who did not in MMPI 2-point-code ratings and mean social adjustment scale scores. These findings may provide prognostic indicators for response to LAAM, a possible alternative to methadone.
Informed consent as a form of volunteer bias
Authors: M J Edlund, T J Craig, M A Richardson
Journal: American Journal of Psychiatry (1985)

Two nontreatment studies of tardive dyskinesia were examined to see if giving or refusing informed consent might bias results. Three prominent psychiatric journals were also reviewed to determine whether the outcome of informed consent procedures was sufficiently well described to permit evaluation of potential bias. The nontreatment studies suggested that the bias created by requiring informed consent may cause both false-positive and false-negative findings. The literature review showed that treatment studies have generally ignored the potential impact of these biases on results. Accurate interpretation of research reports, particularly clinical trials, demands that more attention be given to the process of obtaining and reporting informed consent.
A national study of psychiatric hospital care
Authors: R A Dorwart, M Schlesinger, H Davidson, S Epstein, C Hoover
Journal: American Journal of Psychiatry (1991)

The delivery system for psychiatric inpatient services in the United States has changed dramatically over the past 30 years, undergoing a marked privatization.To assess the effect of changes in ownership and types of inpatient settings on the structure of the mental health services system, the authors surveyed a national sample of nonfederal mental health facilities in 1988.Comparing their data to those of earlier surveys, they found that a decline in the number of patients per staff occurred in most settings over the last decade, suggesting that this aspect of quality of care may have improved. They observed important ownership-related differences in 1988 in diagnostic mix (e.g., more schizophrenia treated in public facilities than in private ones) and in payer source (e.g., more third-party revenues in public facilities than occurred in the past).There was a significant interaction between ownership form and type of facility, suggesting that the type of inpatient setting, ownership, and the relation between the two should be considered in assessing the impact of privatization on the accessibility of health care available for the mentally ill. The authors found that the increase in private psychiatric hospitals has widened the availability and choice of treatment facilities for those with private funding sources (especially children and adolescents) but has not had a similar effect in increasing sources of care for the seriously mentally ill dependent upon public financing.
Whole Exome Sequencing To Estimate Alloreactivity Potential Between Donors and Recipients In Stem Cell Transplantation
Authors: Juliana Sampson, Nihar Sheth, Vishal N Koparde, Allison Scalora, Myrna G Serrano, Vladimir Lee, Maximillian Jamison-Lee, Andrea Ferreira-Gonzalez, Catherine H Roberts, Masoud H Manjili, Gregory Buck, Michael C Neale, Amir A Toor MD
Journal: Blood (2013)
Detection of Minimal Residual Disease in Acute Leukemia by Tc-99m MIBI Femoral Marrow Imaging
Authors: SHIGETOSHI WAKASUGI, KENSUKE OHTA, YOSHIHISA HASEGAWA, NORIYUKI TATUMI, HIROYUKI NAKAMURA
Journal: Clinical Nuclear Medicine (2001)

To determine the potential of Tc-99m MIBI femoral marrow imaging for detecting minimal residual disease in acute leukemia, MIBI images of 68 patients with acute leukemia and 110 control patients were examined. MIBI accumulation was classified into three patterns: not detectable, mild accumulation, and clearly visualized accumulation. Clearly visualized accumulation was interpreted as abnormal. The mean uptake ratio of the femoral marrow to muscle was calculated. Forty-five patients who were in complete remission (CR) at the time of MIBI imaging had a follow-up study (mean interval, 23 months). Clearly visualized accumulation was demonstrated in 35 patients with acute leukemia: in 7 patients before starting induction chemotherapy, in 12 patients after relapse, and in 16 of the 49 patients in the CR group. Mild accumulation was demonstrated in 14 patients in the CR group and in 13 control group patients. No detectable accumulation was observed in 19 patients in the CR group and in 97 control patients. The marrow and muscle uptake ratio of patients before starting chemotherapy (2.29 +/- 0.26) was greater compared with that in patients after relapse (1.78 +/- 0.44, P < 0.02) and in patients with abnormal accumulation despite complete remission (1.84 +/- 0.36, P < 0.01). The uptake ratio in patients with abnormal accumulation despite CR was higher compared with patients with mild accumulation in CR (1.26 +/- 0.13, P < 0.001) and controls (1.23 +/- 0.10, P < 0.001) who had mild accumulation. Fifteen patients with abnormal accumulation despite CR had a markedly greater relapse rate (66.7% > 10.0%, P < 0.005), a higher mortality rate (46.7% > 6.7%, P < 0.01), and shorter remission time (8.7 +/- 10.2 months < 35.9 +/- 20.1 months, P < 0.001) compared with 30 patients without abnormal accumulation in CR. MIBI femoral marrow imaging may be a useful and simple method for monitoring levels of residual leukemic cells. Clearly visualized MIBI accumulation may be a marker for relapse.
Case 52-1966
Authors: Richard Gorlin, Benjamin Castleman
Journal: New England Journal of Medicine (1966)

Presentation of CaseA seventy-two-year-old man entered the hospital because of dyspnea.He had felt well all his life and had never been examined by a physician. Four days before admission a sharp substernal pain and dyspnea developed while he was walking; the pain was aggravated by deep breathing and by coughing. On the following day he began to cough up blood-tinged sputum. The pain in the chest disappeared during the ensuing twenty-four hours. On the evening of admission the dyspnea increased, and he was brought to the Emergency Ward.There was no history of smoking or ingestion of alcohol. . . .