tbuckley/cabot-search huggingface dataset:
Evaluation of Procedures Designed to Enhance Coronary Collateral Blood Flow
Authors: Robert M. Berne, Richard D. Jones, Frederick S. Cross
Journal: Circulation Research (1962)

Three procedures reported to improve the coronary collateral circulation were carried out in dogs: (1) placement of 0.25 to 0.5 Gm. of sterile shredded asbestos over the surface of the heart; (2) suturing of the mediastinal fat pad to the abraded left lateral surface of the heart in conjunction with the application of asbestos; (3) implantation of the internal mammary artery into the left ventricular wall in conjunction with application of Ivalon sponge to the denuded surface of the left ventricle. The effectiveness of these measures was determined in dogs with previously narrowed left circumflex coronary arteries. As judged by retrograde flows and peripheral coronary pressures, the collateral vessel development was not increased over and above that produced by narrowing alone. Coronary artery injection studies revealed that only internal mammary artery implantation produced vascular connections between cardiac and extra-cardiac vessels.
DNA sequencing to identify potentially novel targets for therapy in pancreatic cancer.
Authors: Jeffrey Toll, Arsen Osipov, Jasleen Khanuja, Dana Pan, Rishi Patel, Jenny Zhou, Arvind Manohar Shinde, Alagappan Annamalai, Andrew Eugene Hendifar, Richard Tuli
Journal: Journal of Clinical Oncology (2016)

275 Background: Molecular differences in solid tumors have been shown to correlate with heterogeneity of response. Unfortunately, minimal data exists in pancreatic ductal adenocarcinoma (PDA). Next generation sequencing (NGS) may provide genetic signatures that allow prognostic stratification and predict response to targeted therapy. Methods: DNA was extracted from biopsy specimens of 64 patients (pts) with PDA at Cedars-Sinai Medical Center. DNA sequencing was performed for 3,769 exons of 236 cancer-related genes plus 47 introns from 19 genes to an average depth of 1000X using the Illumina HiSeq 2000 platform (Foundation Medicine, Cambridge, MA). We report all genetic alterations including those classified as variants of unknown significance (VUS) as these may potentially be important for further study. Results: 94% of our patients had KRAS mutations, SMAD(39%) P53 (69%), and CDKN2A (48%). 17% of the pts had all 4 mutations. 4.6% had none. MLL and ARID genes, both involved in chromatin remodeling, were altered in (45%) and (35%) of the patients respectively. Alterations in MLL2 (22%) have been previously described. Interestingly, we also identified mutations in MLL3 (15%) and MLL (8%) of patients. We also identified an equal frequency of mutations in ARID1A mutations (17%) and ARID 1B (17%). ATM (19%) and ATR (11%) genes involved in double stranded DNA repair were mutated in a total of 30%. BRCA1 (12.5%) and BRCA2 (14%) were mutated in 26.5%, and PALB2 in another 2%. PMS2 (mismatch repair) was also mutated in 9% of patients. In total 67% of patients had alterations in one of these DNA repair pathways. There were a number of other genes noted to harbor mutations in greater than 10% of patients including BCOR, which is known to interact with MLL and seen in acute leukemia, FANC complex, GPR124 (angiogenesis), as well IRS2, PIK3A in the akt-PIK pathway. Conclusions: NGS in a cohort of advanced pancreatic cancer patients identified novel alterations in genes associated with chromatin modeling and DNA repair. These pathways may serve as potential avenues for targeted therapy in pancreatic cancer.
Double Expressing (MYC/BCL2) and Double-Hit Diffuse Large B-Cell Lymphomas Have Inferior Survival Following Autologous Stem Cell Transplantation
Authors: Alex F. Herrera, Matthew G. Mei, Lawrence Low, Reid W. Merryman, Joo Y. Song, Tanya Paris, Tracey Stiller, Victoria Bedell, Heather Sun, Jennifer R. Brown, Lihua Elizabeth Budde, Robert Chen, Matthew S. Davids, Arnold S. Freedman, David C. Fisher, Eric D. Jacobsen, Caron A. Jacobson, Haesook T. Kim, Ann S. LaCasce, Joyce Murata-Collins, Auayporn P. Nademanee, Joycelynne Palmer, German A. Pihan, Tanya Siddiqi, Aliyah R Sohani, Leslie L. Popplewell, Jasmine Zain, Larry W. Kwak, David M. Weinstock, Stephen J. Forman, Dennis D. Weisenburger, Young Kim, Scott J. Rodig, Amrita Krishnan, Philippe Armand
Journal: Blood (2015)
AT-13THE EU-RHAB EXPERIENCE: CLINICAL, GENETIC AND SURVIVAL DATA DEFINE A STANDARD OF CARE AND ARE THE BASIS FOR CLINICAL TRIALS
Authors: Michael Frühwald, Karolina Nemes, Paul-Gerhard Schlegel, Irene Schmid, Joachim Gerss, Reinhard Schneppenheim, Reiner Siebert, Kornelius Kerl, Pablo Hernaiz-Driever, Marcel Kool, Martin Hasselblatt, Karsten Nysom
Journal: Neuro-Oncology (2016)
Cardio-Vascular Events Occurring On Ponatinib In Chronic Phase Chronic Myeloid Leukemia Patients, Preliminary Analysis Of a Multicenter Cohort
Authors: Franck E. Nicolini, Marie-Claude Gagnieu, Mael Heiblig, Emilie Blond, Laurence Legros, Yann Guillermin, Stephane Morisset, Fiorenza Barraco, Madeleine Etienne, Oriane Le Borgne, Jeremy Ruby, Mohamad Sobh, Gaelle Richard-Colmant, Celine Fettig, Mauricette Michallet, Delphine Rea
Journal: Blood (2013)
The mutual relevance of teaching and cultural attraction
Authors: Thomas C. Scott-Phillips, Dan Sperber
Journal: Behavioral and Brain Sciences (2015)

Abstract As Kline envisages, there is an important relationship between cultural attraction and teaching. The very function of teaching is to make the content taught an attractor. Teaching, moreover, typically fulfills its function by exploiting a variety of factors of cultural attraction that help make its content learnable and teachable.
What are the most efficacious treatment regimens for isoniazid-resistant tuberculosis? A systematic review and network meta-analysis
Authors: H R Stagg, R J Harris, H-A Hatherell, D Obach, H Zhao, N Tsuchiya, K Kranzer, V Nikolayevskyy, J Kim, M C Lipman, I Abubakar
Journal: Thorax (2016)

<h3>Introduction</h3> Consensus on the best treatment regimens for patients with isoniazid-resistant TB is limited; global treatment guidelines differ. We undertook a systematic review and meta-analysis using mixed-treatment comparisons methodology to provide an up-to-date summary of randomised controlled trials (RCTs) and relative regimen efficacy. <h3>Methods</h3> Ovid MEDLINE, the Web of Science and EMBASE were mined using search terms for TB, drug therapy and RCTs. Extracted data were inputted into fixed-effects and random-effects models. ORs for all possible network comparisons and hierarchical rankings for different regimens were obtained. <h3>Results</h3> 12 604 records were retrieved and 118 remained postextraction, representing 59 studies—27 standalone and 32 with multiple papers. In comparison to a baseline category that included the WHO-recommended regimen for countries with high levels of isoniazid resistance (rifampicin-containing regimens using fewer than three effective drugs at 4 months, in which rifampicin was protected by another effective drug at 6 months, and rifampicin was taken for 6 months), extending the duration of rifampicin and increasing the number of effective drugs at 4 months lowered the odds of unfavourable outcomes (treatment failure or the lack of microbiological cure; relapse post-treatment; death due to TB) in a fixed-effects model (OR 0.31 (95% credible interval 0.12–0.81)). In a random-effects model all estimates crossed the null. <h3>Conclusions</h3> Our systematic review and network meta-analysis highlight a regimen category that may be more efficacious than the WHO population level recommendation, and identify knowledge gaps where data are sparse. <h3>Systematic review registration number</h3> PROSPERO CRD42014015025.
SCREENING FOR GALACTOSEMIA AND PHENYLKETONURIA
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Antibiotic-induced gut microbiota disruption during human endotoxemia: a randomised controlled study
Authors: Jacqueline M Lankelma, Duncan R Cranendonk, Clara Belzer, Alex F de Vos, Willem M de Vos, Tom van der Poll, W Joost Wiersinga
Journal: Gut (2016)

<h3>Objective</h3> The gut microbiota is essential for the development of the intestinal immune system. Animal models have suggested that the gut microbiota also acts as a major modulator of systemic innate immunity during sepsis. Microbiota disruption by broad-spectrum antibiotics could thus have adverse effects on cellular responsiveness towards invading pathogens. As such, the use of antibiotics may attribute to immunosuppression as seen in sepsis. We aimed to test whether disruption of the gut microbiota affects systemic innate immune responses during endotoxemia in healthy subjects. <h3>Design</h3> In this proof-of-principle intervention trial, 16 healthy young men received either no treatment or broad-spectrum antibiotics (ciprofloxacin, vancomycin and metronidazole) for 7 days, after which all were administered lipopolysaccharide intravenously to induce a transient sepsis-like syndrome. At various time points, blood and faeces were sampled. <h3>Results</h3> Gut microbiota diversity was significantly lowered by the antibiotic treatment in all subjects. Clinical parameters, neutrophil influx, cytokine production, coagulation activation and endothelial activation during endotoxemia were not different between antibiotic-pretreated and control individuals. Antibiotic treatment had no impact on blood leucocyte responsiveness to various Toll-like receptor ligands and clinically relevant causative agents of sepsis (<i>Streptococcus pneumoniae, Klebsiella pneumoniae, Escherichia coli</i>) during endotoxemia. <h3>Conclusions</h3> These findings suggest that gut microbiota disruption by broad-spectrum antibiotics does not affect systemic innate immune responses in healthy subjects during endotoxemia in humans, disproving our hypothesis. Further research is needed to test this hypothesis in critically ill patients. These data underline the importance of translating findings in mice to humans. <h3>Trial registration number</h3> ClinicalTrials.gov (NCT02127749; Pre-results).
Endoscopic transgastric pancreatic fistula anastomosis as treatment for a refractory pancreatic duct leak after distal pancreatectomy
Authors: Ryan Law, Ian Grimm, Todd Baron
Journal: Endoscopy (2016)

A 45-year-old man underwent distal pancreatectomy for chronic pancreatitis. Over the ensuing 2 years he developed recurrent pancreatic fluid collections (PFCs) from pancreatic duct leakage at the resection site. He underwent repeated surgery, percutaneous drainage, and placement of pancreatic duct stents. Endoscopic transmural drainage was suggested on several occasions but rejected by the surgical team.
Near real-time space-time cluster analysis for detection of enteric disease outbreaks in a community setting
Authors: Aharona Glatman-Freedman, Zalman Kaufman, Eran Kopel, Ravit Bassal, Diana Taran, Lea Valinsky, Vered Agmon, Manor Shpriz, Daniel Cohen, Emilia Anis, Tamy Shohat
Journal: Journal of Infection (2016)
<sup>32</sup>P-Postlabeling Analysis of Binding of the Cyclophosphamide Metabolite, Acrolein, to DNA
Authors: A E Maccubbin, L Caballes, F Scappaticci, R F Struck, H L Gurtoo
Journal: Cancer Communications (1990)

The cyclophosphamide metabolite, acrolein, was reacted with 2'-deoxyguanosine-3'-monophosphate, and two adducts were detected by high performance liquid chromatography and 32P-postlabeling assay. These adducts were resistant to dephosphorylation by nuclease P1 and could be isolated and detected from calf thymus DNA that had been reacted in vitro with acrolein. A combination of HPLC purification and enzymatic digestion of normal nucleotides by nuclease P1 allowed for the detection of these adducts in hepatic DNA from mice treated with cyclophosphamide. The level of the two adducts in the hepatic DNA, as determined by 32P-postlabeling, was one adduct per 2.7-4.1 x 10(7) normal nucleotides.
HBV-Associated Acute Liver Failure After Immunosuppression and Risk of Death
Authors: Constantine J. Karvellas, Filipe S. Cardoso, Michelle Gottfried, K. Rajender Reddy, A. James Hanje, Daniel Ganger, William M. Lee, W.M. Lee, Anne M. Larson, Iris Liou, Oren Fix, Michael Schilsky, Timothy McCashland, J. Eileen Hay, Natalie Murray, A. Obaid S. Shaikh, Andres Blei, Daniel Ganger, Atif Zaman, Steven H.B. Han, Robert Fontana, Brendan McGuire, Raymond T. Chung, Alastair Smith, Robert Brown, Jeffrey Crippin, Edwin Harrison, Adrian Reuben, Santiago Munoz, Rajender Reddy, R. Todd Stravitz, Lorenzo Rossaro, Raj Satyanarayana, Tarek Hassanein, Constantine J. Karvellas, Jodi Olson, Ram Subramanian, James Hanje
Journal: Clinical Gastroenterology and Hepatology (2016)
Air Pollution and Human Health
Authors: Mary O. Amdur
Journal: New England Journal of Medicine (1962)

OVER the last decade responsible public-health agencies have evidenced increasing concern about the possible adverse effects of pollution of urban atmospheres on human health. On several occasions this problem has received dramatic emphasis when local meteorologic conditions have produced a stagnant air mass remaining for several days, thus causing an increase in pollution levels above those normally present, with a concurrent rise in mortality and morbidity. Examples of such incidents occurred in the Meuse Valley in Belgium in 1930, in Donora, Pennsylvania, in 1948, and in London in 1952.From a study of these disasters something of the acute effects . . .
QOS-38ENDOCRINE SEQUELAE AMONG CHILDREN WITH CENTRAL NERVOUS SYSTEM TUMORS AFTER MULTIMODAL ONCOLOGY TREATMENT
Authors: Jovana Dimic, Vesna Ilic, Vladislav Bojic, Marina Nikitovic, Lejla Paripovic, Jelena Bokun, Vera Zdravkovic
Journal: Neuro-Oncology (2016)
Genome-Wide Gene Expression Profiling of Randall’s Plaques in Calcium Oxalate Stone Formers
Authors: Kazumi Taguchi, Shuzo Hamamoto, Atsushi Okada, Rei Unno, Hideyuki Kamisawa, Taku Naiki, Ryosuke Ando, Kentaro Mizuno, Noriyasu Kawai, Keiichi Tozawa, Kenjiro Kohri, Takahiro Yasui
Journal: Journal of the American Society of Nephrology (2016)

Randall plaques (RPs) can contribute to the formation of idiopathic calcium oxalate (CaOx) kidney stones; however, genes related to RP formation have not been identified. We previously reported the potential therapeutic role of osteopontin (OPN) and macrophages in CaOx kidney stone formation, discovered using genome-recombined mice and genome-wide analyses. Here, to characterize the genetic pathogenesis of RPs, we used microarrays and immunohistology to compare gene expression among renal papillary RP and non-RP tissues of 23 CaOx stone formers (SFs) (age- and sex-matched) and normal papillary tissue of seven controls. Transmission electron microscopy showed OPN and collagen expression inside and around RPs, respectively. Cluster analysis revealed that the papillary gene expression of CaOx SFs differed significantly from that of controls. Disease and function analysis of gene expression revealed activation of cellular hyperpolarization, reproductive development, and molecular transport in papillary tissue from RPs and non-RP regions of CaOx SFs. Compared with non-RP tissue, RP tissue showed upregulation (˃2-fold) of LCN2 , IL11 , PTGS1 , GPX3 , and MMD and downregulation (0.5-fold) of SLC12A1 and NALCN ( P &lt;0.01). In network and toxicity analyses, these genes associated with activated mitogen-activated protein kinase, the Akt/phosphatidylinositol 3-kinase pathway, and proinflammatory cytokines that cause renal injury and oxidative stress. Additionally, expression of proinflammatory cytokines, numbers of immune cells, and cellular apoptosis increased in RP tissue. This study establishes an association between genes related to renal dysfunction, proinflammation, oxidative stress, and ion transport and RP development in CaOx SFs.
Brief Communication: Presence of A-Type and Absence of C-Type Virus Particles in a Chemically Induced Guinea Pig Hepatoma
Authors: V. C. Dunkel, R. C. Bast, B. I. Gerwin, U. Heine, M. Cottler-Fox, T. Borsos
Journal: JNCI Journal of the National Cancer Institute (1974)

C-type virus particles and reverse transcriptase activity could not be detected in cells from a diethylnitrosamine-induced guinea pig hepatoma after treatment with 5-bromo-2′-deoxyuridine (5-BUDR) or 5-iodo-2′-deoxyuridine (5-IUDR) in cell culture. A-type particles were found in the presence or absence of 5-BUDR.
Nonmalignant Diagnoses in Patients
Authors: Ann Partridge, Mairin Mcmenamin, David Sugarbaker
Journal: Journal of Clinical Oncology (2000)

Article Tools Nonmalignant Diagnoses in Patients Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.13.2636 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 10893298 Nonmalignant Diagnoses in Patients Ann PartridgexAnn PartridgeSearch for articles by this author , Mairin McmenaminxMairin McmenaminSearch for articles by this author , David SugarbakerxDavid SugarbakerSearch for articles by this author Show More Departments of Medicine, Pathology, and Surgery; Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and Harvard Medical School; Boston, MA https://doi.org/10.1200/JCO.2000.18.13.2636 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology
European Perspectives
Authors: Albert Fenech
Journal: Circulation (2007)

Great Britain acquired possession of Malta in 1814.The island staunchly supported the United Kingdom through both World Wars and remained in the Commonwealth when it became independent in 1964.* Malta became a republic in 1974.* Malta's main commercial activities are freight transshipment, finance, and tourism.* Malta became a European Union member in May 2004.* Malta has total land area of 316 km 2 .* The estimated population for 2007 is 401,880.* The country comprises Malta and the adjacent islands of Gozo, Comino, and the tiny, uninhabited Filfla.
Low Birthweight — United States, 1975-1987
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMMENTARY: Phase II Trial Design Considerations for Small-Cell Lung Cancer
Authors: T. D. Moore, E. L. Korn
Journal: JNCI Journal of the National Cancer Institute (1992)

Therapeutic options for the systemic treatment of small-cell lung cancer have not improved substantially in the past 15 years.Recognition of effective new chemotherapeutic agents is crucial, since this cancer is generally considered to be a disseminated disease at presentation.Recently, several publications have implied that many phase II studies have not been designed to evaluate fairly an investigational agent's efficacy in the treatment of this disease (1-4).Several different strategies have been proposed for testing new agents.This commentary critiques these options and presents recommendations for the design of future phase II investigational drug trials in small-cell lung cancer.
The dynamics of hospitalization in a defined population during deinstitutionalization
Authors: T J Craig, A B Goodman, C Siegel, J Wanderling
Journal: American Journal of Psychiatry (1984)

In a sample of 1,032 psychiatric inpatients studied for 1 year, chronic patients (more than 6 months' inpatient stay) represented 17.4%, almost half of whom were discharged during a 2-year follow-up; an additional 19.4% died. The incidence of "new" long-stay patients was 8.6/100,000 population, which, if constant over time, would result in a net increase of long-stay patients. Most chronic long-stay patients had a diagnosis of schizophrenia or organic brain syndrome. The two diagnostic groups had strikingly different patterns of deinstitutionalization. Alcoholic patients and those with "other" diagnoses demonstrated chronic dependence on the hospital, characterized by short inpatient stays and high readmission rates.
Palliative Care Ethics: A Case Commentary on Discontinuing Interventions at the End of Life
Authors: Dorothy E. Vawter, David Engelstad, Jason Kallestad
Journal: The American Journal of Bioethics (2016)

Ms. Demir initially seeks to return home with hospice and continue to receive blood products and high-flow oxygen as long as her quality of life is satisfactory to her. In light of restricted optio...
Clinical presentation, karyotypic characterization, and treatment outcome of childhood acute lymphoblastic leukemia with a near-haploid or hypodiploid less than 45 line
Authors: CH Pui, AJ Carroll, SC Raimondi, VJ Land, WM Crist, JJ Shuster, DL Williams, DJ Pullen, MJ Borowitz, FG Behm
Journal: Blood (1990)
Abstract 17150: Myocardial Fibrosis by T1 Mapping is an Early Indicator of Severe Cardiac Allograft Vasculopathy
Authors: S. C Masri, Ganesh Raveendran, Nonye Harcourt, Monica Colvin
Journal: Circulation (2013)

Background: Cardiac allograft vasculopathy (CAV) is associated with late graft failure and mortality. Recognition of graft dysfunction due to CAV using current criteria occurs late and implies poor...
A novel deletion of approximately 27 kb including the beta-globin gene and the locus control region 3'HS-1 regulatory sequence: beta zero- thalassemia or hereditary persistence of fetal hemoglobin?
Authors: AJ Dimovski, V Divoky, AD Adekile, E Baysal, JB Wilson, JF Prior, JL Raven, TH Huisman
Journal: Blood (1994)
HG-123AN EPIGENOMIC SCREEN REVEALS THE CHROMATIN REMODELING PROTEIN BPTF AS A DRIVER OF HIGH-GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA GROWTH IN VITRO AND IN VIVO
Authors: Adam Green, Patrick Flannery, John DeSisto, Madeleine Lemieux, Shak Ramkissoon, Kristen Jones, Jennifer Perry, Benjamin Hubbell-Engler, Deborah DeRyckere, Sujatha Venkataraman, Nicholas Foreman, Stuart Orkin, Keith Ligon, Ken Jones, Doug Graham, Andrew Kung, Rajeev Vibhakar
Journal: Neuro-Oncology (2016)