tbuckley/cabot-search huggingface dataset:
A Case of Intraductal Papilloma of the Breast With High 18F-FDG Uptake on PET/CT
Authors: Megumi Jinguji, Yoriko Kajiya, Masayuki Nakajo, Michiyo Higashi, Takashi Yoshiura
Journal: Clinical Nuclear Medicine (2015)

We present a case of intraductal papilloma in the right breast of a 51-year-old woman with high F-FDG uptake. Its maximum standardized uptake value increased from 10.2 on early (1 h) PET/CT scan to 12.2 on delayed (2 h) PET/CT scan suggesting a primary breast cancer. However, histopathology proved it to be an intraductal papilloma. Immunohistochemically, strong expression of glucose transporter-1 and weak expression of hexokinase-II were noted in the papilloma. With the detection of a subareolar intracystic mass with high F-FDG uptake, intraductal papilloma should be included in the differential diagnosis.
Correlates of patient attendance in an inner-city mental health clinic
Authors: T J Craig, C L Huffine
Journal: American Journal of Psychiatry (1976)

Of 140 patients seen at a psychiatric clinic serving a predominantly black, low-income population, 65% attended for four or more visits. Patients over age 30 and those with a diagnosis of psychosis or personality disorder remained in therapy for significantly longer periods than the rest of the group. Failure to prescribe medication was associated with early dropout, but this effect seemed to be attenuated with duration of therapy. The race of the patients and therapists did not seem to influence continuation in treatment, but such an influence may have been masked by differences in the therapists' experience.
Increased Expression Of IL-15 Promotes Cutaneous T-Cell Lymphomagenesis Via The Upregulation Of Histone Deacetylases: Evidence For Successful Preclinical Targeting
Authors: Anjali Mishra, Krista M.D. La Perle, Laura Sullivan, Gregory H Sams, Douglas P Curphey, Kathleen McConnell, Jun Qi, Henry K Wong, Samuel K Kulp, Soledad Fernandez, James E Bradner, Guido Marcucci, Ching-Shih Chen, Pierluigi Porcu, Michael A. Caligiuri
Journal: Blood (2013)
The Cost of Medicare Advantage
Authors: Austin B. Frakt
Journal: JAMA (2016)

fulness practices and the optimal time and methods for such practices to reduce pain, Zeidan said.Additional research also is needed to compare mindfulness-based techniques like meditation directly with opioid and nonopioid medications, Briggs added."It is a very interesting lack in our research portfolio," Briggs said."People propose meditation compared to a [patient health] education control, but not this direct head-to-head comparison or even a study to see if the availability of mindfulness training results in reduced opioid use."Schoomaker said researchers and clinicians need to broaden the end point for pain relief studies beyond a numeric scale to holistically evaluate how the therapy improves the patient's overall quality of life.
Adrenocortical function and depressive illness in mentally retarded patients
Authors: S L Ruedrich, C V Wadle, H S Sallach, R K Hahn, F J Menolascino
Journal: American Journal of Psychiatry (1987)

The authors administered a 1-mg dexamethasone suppression test (DST) to 85 institutionalized adults with mild to profound mental retardation after screening to exclude false-positive nonsuppression. Thirty-one (36%) of these subjects had baseline hypercortisolemia, which was significantly correlated with age, symptoms, and "modified" DSM-III criteria for major depressive disorder. Twenty (24%) of the 85 subjects were nonsuppressors (5 micrograms/dl) after testing; nonsuppression was significantly related to age, female sex, level of retardation, symptoms, and "modified" DSM-III criteria for major depressive disorder (sensitivity 41%, specificity 81%). First-order partial correlations maintained significant relationships between age and severity of retardation but not sex. Mental retardation itself did not appear to invalidate the DST.
HG-04DICHLOROACETATE AND METFORMIN COMBINE TO MODULATE GLUCOSE METABOLISM AND POTENTLY SENSITISE DIPG CELLS TO RADIATION THERAPY
Authors: Han Shen, Maria Tsoli, Cecilia Chang, Arjanna Chitranjan, Jie Liu, Eric Hau, Anne Kankean, Anahid Ehteda, Laura Franshaw, Santosh Valvi, David Ziegler
Journal: Neuro-Oncology (2016)
Dimensions of the Therapeutic Milieu: A Study of Mental Hospital Atmosphere
Authors: Lee Gurel
Journal: American Journal of Psychiatry (1974)

Even though the environment of a mental hospital exerts a direct effect on the patient and even though evaluations of mental hospital performance take place constantly in the political arena, mental health professionals remain basically ignorant of how to measure or conceptualize a beneficial treatment environment. This paper is an attempt to extend the methodology for studying the "atmosphere" of mental hospitals through the use of objective indices of hospital performance and factor analysis. Applying this technique to 41 Veterans Administration psychiatric hospitals, the author identifies four factors and discusses their relationship to the objective characteristics of the hospitals.
Soundings: Occam's razor
Authors: Kevin Barraclough
Journal: BMJ (2002)

I remember an event when I was 17, and only three days into university. I was cycling across a green towards the river when I saw a startlingly beautiful young woman walking slowly along the towpath. She seemed to be, like myself, on the edge of childhood, when the colours of the world were vivid with the uncertainty of adulthood. Subsequently I always watched for her, but only saw her again once, more than 10 years later.

I was sitting on a Circle line tube in Edgware Road station quite late on a weekday evening. The train was deserted and on the other platform was another, almost empty train. I think it was summer because the air had the stillness peculiar to long evenings. I looked across at the train on the other platform and there she was, alone in the carriage. She looked older, an adult now, and tired. As I watched she shut her eyes and stretched her arms above her head. She sniffed her armpit and grimaced. I felt rather embarrassed, a voyeur on this intimate moment, and then the train moved away. I remember being unsure whether it was she or I who was moving—we were the John and Jane of textbook relativity problems.

I quite like things like that because they are somehow incompressible. You can theorise all you like but you will scrape no drop of meaning from it. Life just throws up these meaningless juxtapositions of events that have an indefinable resonance. It is almost as though there are elemental patterns in the world that cannot be further reduced—a threshold of complexity that defies further codification. It is like the staccato conversation in an Alan Bennett play—tangential and meaningless, yet conveying human frailties with an irreducible economy.

Quite a lot of what I see in medicine is like that. The newly qualified consultant, afraid of failure, buckles the facts in order to shoehorn every patient into a clean diagnosis. But in medicine Occam's razor has often been blunted by the relentless weathering of decades of emotional and physical drizzle in an old and crumpled universe. The osteopath's absurdly anatomical diagnosis of a left L5/S1 facet joint dislocation imposes a spurious simplicity on a blizzard of dissatisfactions with the world. I suspect that sometimes the failure to find patterns in the world is not a failure at all.
Managed care constraints on psychiatrists' hospital practices: bargaining power and professional autonomy
Authors: M Schlesinger, R A Dorwart, S S Epstein
Journal: American Journal of Psychiatry (1996)

The increasing involvement of insurers and hospitals in monitoring patient care is encroaching on the psychiatrist's autonomy in making clinical decisions. This study examined the prevalence of constraints on psychiatric inpatient practices, as well as how characteristics of psychiatrists affect the type and the degree of these external pressures.About 2,500 psychiatrists with active hospital affiliations were surveyed by mail, as a subset of APA's 1988 national survey of psychiatrists. They were questioned about whether the hospital or insurers had pressured them to change their inpatient practices or had attempted to discourage admission of certain types of patients. Characteristics of the psychiatrists' background, available from the main survey, were used as independent variables in a set of regression models, with frequency of different constraints as the dependent variables.More than three quarters of those surveyed reported pressure from insurers for early discharge; nearly two-thirds said hospitals limited length of stay; and about half had been discouraged from admitting severely ill patients, the uninsured, or Medicaid recipients. Characteristics of psychiatrists, such as length of time in practice, income, sex, and medical school education outside the United States, were associated with the prevalence of external pressures.Constraints on psychiatrists' practices are widespread. Their ability to resist pressures depends on their bargaining power, which seems to be lowest for those who have relatively little experience, who are female, or who have gone to medical school outside the United States. Psychiatrists appear to be willing to trade off more constraints for higher incomes. Severely ill patients and those with little or no insurance are more likely than others to be affected by these limits on psychiatrists' autonomy.
RO-23RECURRENT EPENDYMOMA A CHALLENGING THERAPY: RE-IRRADIATION PROLONGS SURVIVAL IN FAILURE OF RADICAL RESECTION
Authors: Stephan Tippelt, Ruth Mikasch, Monika Warmuth-Metz, Torsten Pietsch, Robert Kwiechien, Andreas Faldum, Stefan Rutkowski, Katja Von Hoff, Martin Mynarek, Udo Bode, Nele Siegler, Gudrun Fleischhack, Rolf-Dieter Kortmann
Journal: Neuro-Oncology (2016)

RO-23. RECURRENT EPENDYMOMA A CHALLENGING THERAPY: RE-IRRADIATION PROLONGS SURVIVAL IN FAILURE OF RADICAL RESECTION Stephan Tippelt1,RuthMikasch1,Monika Warmuth-Metz5,Torsten Pietsch7, Robert Kwiechien3, Andreas Faldum3, Stefan Rutkowski2, Katja Von Hoff2, Martin Mynarek2, Udo Bode4, Nele Siegler1, Gudrun Fleischhack1, and Rolf-Dieter Kortmann6; University Hospital Essen, Pediatric Hematology and Oncology, Essen, Germany; University Hospital Hamburg, Pediatric Hematology and Oncology, Hamburg, Germany; University Munster, Institute of Biostatistics and Clinical Research, Munster, Germany; University of Bonn, Childrens Hospital, Pediatric Hematology and Oncology, Bonn, Germany; University of Wuerzburg, Neuroradiology, Wurzburg, Germany; University of Leipzig, Department of Radiotherapy and Radioonkology, Leipzig, Germany; University of Bonn, Medical Center, Institute of Neuropathology, Bonn, Germany INTRODUCTION: In pediatric patients with ependymoma the 10-year overall survival (OS) rate is 64% with poor 5-year OS rates of only 42-55% in infancy. Beside maximal radical resection local radiotherapy is standard of care; chemotherapy is controversially discussed. In recurrence treatment options are rare. Re-resection with maximal radical intense is indicated in local relapses. In unresectable or metastatic disease longterm prognosis is fatal. Merchant et al. and others showed prolonged OS rates after re-irradiation even in metastatic disease. PATIENTS AND METHODS: From 55 patients of the German HIT2000 and HIT-REZ study cohort with recurrent ependymomaswhoreceivedre-irradiationdataasage; stageofdisease; time and extent of surgery; time, dose and volume of radiotherapy; time and kind of chemotherapy at primary diagnosis and relapse; date and disease state at last follow up and causes of death were analyzed. OS time was estimated based on Kaplan–Meier-analysis and compared to a cohort of 40 patients without re-irradiation. RESULTS: The 55 patients (74% male) with a median age at primary diagnosis/first recurrence of 5.4/8.4 years showed metastatic disease at recurrence in 47% and a median time to first progression of 22 months. Median OS after first relapse was 31 (CI 21-41) months with 5-year-OS rate of 33%. In comparison to the cohort without re-irradiation significant better 5-year-OS rate was observed in patients with residual tumor at time of re-irradiation (40 vs. 8%). CONCLUSION: Re-irradiation can lead to prolonged survival if radical surgery is impossible and is highly recommended in these cases. Neuro-Oncology 18:iii159–iii164, 2016. doi:10.1093/neuonc/now082.23 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Treatment of Acne Vulgaris.
Authors: M Skendzić, D Blagojević
Journal: JAMA (1924)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HG-122EFFECTS OF THE XPO1 INHIBITOR SELINEXOR ON THE NF-κB PATHWAY IN HIGH-GRADE GLIOMA AND DIFFUSE INTRINSIC PONTINE GLIOMA
Authors: John DeSisto, Patrick Flannery, Trinayan Kashyap, Andrew Kung, Sujatha Venkataraman, Rajeev Vibhakar, Yosef Landesman, Adam Green
Journal: Neuro-Oncology (2016)
Antibiotic resistance in the southeastern Mediterranean – preliminary results from the ARMed project
Authors: M A Borg, E Scicluna, M De Kraker, N Van de Sande-Bruinsma, E Tiemersma, D Gür, S Ben Redjeb, O Rasslan, Z Elnassar, M Benbachir, D Pieridou Bagatzouni, K Rahal, Z Daoud, H Grundmann, J Monen
Journal: Eurosurveillance (2006)

Sporadic reports from centres in the south and east of the Mediterranean have suggested that the prevalence of antibiotic resistance in this region appears to be considerable, yet pan-regional studies using comparable methodology have been lacking in the past. Susceptibility test results from invasive isolates of Staphylococcus aureus, Streptococcus pneumoniae, Escherichia coli, Enterococcus faecium and faecalis routinely recovered from clinical samples of blood and cerebrospinal fluid within participating laboratories situated in Algeria, Cyprus, Egypt, Jordan, Lebanon, Malta, Morocco, Tunisia and Turkey were collected as part of the ARMed project. Preliminary data from the first two years of the project showed the prevalence of penicillin non-susceptibility in S. pneumoniae to range from 0% (Malta) to 36% (Algeria) [median: 29%] whilst methicillin resistance in Staphylococcus aureus varied from 10% in Lebanon to 65% in Jordan [median: 43%]. Significant country specific resistance in E. coli was also seen, with 72% of isolates from Egyptian hospitals reported to be resistant to third generation cephalosporins and 40% non-susceptible to fluoroquinolones in Turkey. Vancomycin non-susceptibility was only reported in 0.9% of E. faecalis isolates from Turkey and in 3.8% of E. faecium isolates from Cyprus. The preliminary results from the ARMed project appear to support previous sporadic reports suggesting high antibiotic resistance in the Mediterranean region. They suggest that this is particularly the case in the eastern Mediterranean region where resistance in S. aureus and E. coli seems to be higher than that reported in the other countries of the Mediterranean.
QOS-54USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION
Authors: Kathleen Dorris, Molly Hemenway, Jennifer Madden, Jean Mulcahy-Levy, Daniel Ambruso, Rajeev Vibhakar, Nicholas Foreman
Journal: Neuro-Oncology (2016)

QOS-54. USE OF CANNABINOIDS IN THE PEDIATRIC CENTRAL NERVOUS SYSTEM TUMOR POPULATION Kathleen Dorris, Molly Hemenway, Jennifer Madden, Jean Mulcahy-Levy, Daniel Ambruso, Rajeev Vibhakar, and Nicholas Foreman; University of Colorado School of Medicine, Aurora, CO, USA BACKGROUND: Cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC), are a class of chemical components that are found in marijuana. Numerous studies in adults have examined the effects of cannabinoids in management of cancer-related symptoms, including nausea, anorexia, and pain. Interest in the lay community in the role of cannabinoids as anticancer therapy is increasing, as some pediatric central nervous system (CNS) tumors have been shown to express cannabinoid receptors. In addition, thepresenceof cannabinoid receptorson immunecells suggests apotential role for cannabinoids as immunomodulators. METHODS: A prospective observational study is underway in Colorado, USA to evaluate serially the impact of cannabinoids on quality of life of pediatric CNS tumor patients who selfmedicate with cannabinoid products using PedsQL 4.0 Generic Core Scales and Brain Tumor and Family Impact modules. Laboratory assessments of neutrophil and T-cell activity will be performed to determine whether cannabinoid use by children with CNS tumors affects immune function and alters risk for infection. Pharmacokinetic analyses of CBD, THC and associated metabolites are planned to gather data regarding metabolism of cannabinoid products in children. Diaries will collect exploratory information on cannabinoid use patterns. Neuropsychological testing is also planned. RESULTS: To date, threepatients (1 medulloblastoma, 1 glioblastoma,and 1 diffuse astrocytoma) have been enrolled. CONCLUSIONS: Accrual is on track to enroll the planned 50 pediatric CNS tumor patients over three years. This novel study should contribute to the increasing understanding of the potential role of cannabinoids in pediatric neuro-oncology. Neuro-Oncology 18:iii145–iii158, 2016. doi:10.1093/neuonc/now081.54 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Point: Impact of Prostate-Specific Antigen Velocity on Management Decisions and Recommendations
Authors: Stacy Loeb, H Ballentine Carter
Journal: Journal of the National Comprehensive Cancer Network (2013)

Prostate-specific antigen (PSA) velocity predicts the presence of prostate cancer on biopsy and a greater risk of prostate cancer death after radical treatment. A new variation on PSA velocity called the risk count was recently shown to provide incremental reclassification for intermediate to high-grade disease on biopsy beyond PSA and age. These markers therefore have the potential to reduce overdiagnosis and overtreatment of indolent prostate cancer, and several professional guidelines support the use of PSA kinetics along with other predictors as part of the diagnostic algorithm. Among men already diagnosed with prostate cancer, PSA kinetics may also be helpful in predicting prognosis after definitive therapy.
Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome
Authors: S Barrio, T D Shanafelt, J Ojha, K G Chaffee, C Secreto, K M Kortüm, S Pathangey, D L Van-Dyke, S L Slager, R Fonseca, N E Kay, E Braggio
Journal: Leukemia (2016)
Monocyte Chemotactic Response in Cancer Patients: A Discussion 01 Statistical Evaluation
Authors: Honor M. Anthony
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Monocyte Chemotactic Response in Cancer Patients: A Discussion 01 Statistical Evaluation Get access Honor M. Anthony Honor M. Anthony Department of Experimental Pathology and Cancer Research School of MedicineLeeds LS2 9NL, England Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 4, April 1975, Page 1015, https://doi.org/10.1093/jnci/54.4.1015 Published: 01 April 1975
MB-48PEROXIREDOXIN 1 IS A POTENTIAL THERAPEUTIC TARGET IN GROUP-3 MEDULLOBLASTOMAS
Authors: Babu Sajesh, Rui Zhong, Yan Wang, Jian-Xin Pu, Han-Dong Sun, Marc Remake, Michael Taylor, Marc Symons, RosaMaria Ruggieri, Magimairajan Issai Vanan
Journal: Neuro-Oncology (2016)
Five‐year histological and serological follow‐up of operationally tolerant pediatric liver transplant recipients enrolled in WISP‐R
Authors: Sandy Feng, Anthony J. Demetris, Katharine M. Spain, Sai Kanaparthi, Bryna E. Burrell, Udeme D. Ekong, Estella M. Alonso, Philip Rosenthal, Laurence A. Turka, David Ikle, Nadia K. Tchao
Journal: Hepatology (2016)

Pediatric liver transplant recipients arguably have the most to gain and the most to lose from discontinuing immunosuppression (IS). Whereas IS undoubtedly exerts a cumulative toll, there is concern that insufficient or no IS may contribute to allograft deterioration. Twelve pediatric recipients of parental living donor liver grafts, identified as operationally tolerant through complete IS withdrawal (WISP‐R; NCT00320606), were followed for a total of 5 years (1 year of IS withdrawal and 4 years off IS) with serial liver tests and autoantibody and alloantibody assessments. Liver biopsies were performed 2 and 4 years off IS, and, at these time points, immunoglobulin G (IgG) subclass and C1q binding activity for donor‐specific antibodies (DSAs) were determined. There were no cases of chronic rejection, graft loss, or death. Allografts did not exhibit progressive increase in inflammation or fibrosis. Smooth‐muscle actin expression by stellate cells and CD34 expression by liver sinusoidal endothelial cells remained stable, consistent with the absence of progressive graft injury. Three subjects never exhibited DSA. However, 3 subjects showed intermittent de novo class I DSA, 4 subjects showed persistent de novo class II DSA, and 5 subjects showed persistent preexisting class II DSA. Class II DSA was predominantly against donor DQ antigens, often of high mean fluorescence intensity, rarely of the IgG3 subclass, and often capable of binding C1q. Conclusion : Operationally tolerant pediatric liver transplant recipients maintain generally stable allograft histology in spite of apparently active humoral allo‐immune responses. The absence of increased inflammation or progressive fibrosis suggests that a subset of liver allografts seem resistant to the chronic injury that is characteristic of antibody‐mediated damage. (H epatology 2017;65:647‐660)