tbuckley/cabot-search huggingface dataset:
Rebiopsy of non-small cell lung cancer patients with acquired resistance to EGFR-TKI: Comparison between T790M mutation-positive and -negative populations.
Authors: Akito Hata, Nobuyuki Katakami, Hiroshige Yoshioka, Jumpei Takeshita, Kosuke Tanaka, Shigeki Nanjo, Reiko Kaji, Shiro Fujita, Yukihiro Imai, Kazuya Monden, Takeshi Matsumoto, Kazuma Nagata, Kyoko Otsuka, Ryo Tachikawa, Keisuke Tomii, Kei Kunimasa, Masahiro Iwasaku, Akihiro Nishiyama, Tadashi Ishida
Journal: Journal of Clinical Oncology (2012)

7528 Background: The secondary epidermal growth factor receptor (EGFR) mutation T790M accounts for approximately half of acquired resistances to EGFR-tyrosine kinase inhibitors (TKI). A recent report has demonstrated the presence of T790M predicts a favorable prognosis and indolent progression, compared to the absence of T790M after TKI failure. However, rebiopsy to confirm T790M status can be challenging due to limited tissue availability and procedural feasibility, and little is known regarding the differences among patients with or without T790M. Methods: We investigated 73 patients harboring EGFR sensitive mutations who had undergone rebiopsy to confirm the emergence of T790M after TKI failure. The peptide nucleic acid-locked nucleic acid PCR clamp method was used in EGFR mutational analyses. Patient characteristics (age, gender, smoking history, performance status, EGFR mutation site, initial TKI, response to initial TKI, line of initial TKI, progression-free survival with initial TKI, and biopsy site) and postprogression survivals (PPS) after initial TKI failure, were retrospectively compared in patients with and without T790M. Results: We identified T790M in 2 (10%) of 21 central nervous system (CNS) (19 cerebrospinal fluid and 2 brain tissue) specimens, and in 20 (38%) of 52 other lesions (25 lung tissue, 24 pleural effusion, and 3 lymph node) (p = 0.0225). Other characteristics had no statistical association with the detection of T790M. Median PPS in patients with T790M was 34.0 months, and in those without T790M, 14.5 months (p = 0.0038). Although none of our patients received TKIs continuously after initial failure, 56 (77%) patients were re-administered TKIs. Regardless of T790M status, PPS in patients with TKI re-administration (23.4 months) was significantly longer than without re-administration (10.4 months) (p = 0.0085). Conclusions: The emergence of T790M in CNS is rare compared with other lesions. Patients with T790M after TKI failure have significantly better prognosis than those without T790M. The effectiveness of TKI re-administration or continuous administration beyond progression is suggested after initial TKI failure.
Vesical Tumors in Patients under 25 Years of Age
Authors: A. Alcaraz, R. Talbot- Wright, R. Samson, C.A. Mestres, M. Puyol, R. Alvarez-Vijande, J.A. Romero, A. Cetina, B. Umbert, P. Carretero
Journal: European Urology (1991)
Medical rhetoric
Authors: S. F Loftus
Journal: BMJ (2010)

<b>Objective.</b> To assess pharmacy educators’ knowledge of medication safety and their perception toward its integration into the PharmD curriculum in Saudi Arabia. <b>Methods.</b> A survey was administered to pharmacy educators at a college of pharmacy and its affiliate hospital. Knowledge, training, and perception toward integrating medication safety into the PharmD curriculum were evaluated. <b>Results.</b> More than 50% of respondents indicated that medication safety should be covered within selected courses, and 65% indicated that such courses should be mandatory. Pharmacy practice educators had significantly higher levels of knowledge about medication safety than their nonpractice counterparts. Perceptions toward medication safety integration into the curriculum varied significantly by general discipline, academic degree, years of experience, and gender. <b>Conclusion.</b> Pharmacy educators in Saudi Arabia understand the importance of medication safety and its integration into the curriculum. Further studies are needed to guide curricular change to achieve this integration.
PD5-3-3: Time course of the stimulating effect of serum on lung cancer cell proliferation after lung resection
Authors: Tatsuya Yoshimasu, Shoji Oura, Takeshi Tamaki, Fuminori Ota, Rie Nakamura, Yukio Shimizu, Yoshimitsu Hirai, Koma Naito, Megumi Kiyoi, Yoshitaka Okamura
Journal: Journal of Thoracic Oncology (2007)
Prognostic factors in elderly patients with advanced gastric cancer
Authors: Toshihiko Matsumoto, Tomohiro Nishina, Akio Nakasya, Takeshi Kajiwara, Kaori Hino, Akinori Asagi, Shinichiro Hori, Seijin Nadano, Natsumi Yamashita, Haruo Iguchi
Journal: Annals of Oncology (2015)
Brief Communication: A White Blood Cell RNase Assay for the Possible Monitoring of Malignancy
Authors: Walter P. Drake/, Dale R. Pokorney, John C. Ruckdeschel, Carl C. Levy, Michael R. Mardiney
Journal: JNCI Journal of the National Cancer Institute (1975)

The RNase activity observed in the sera of leukemic guinea pigs was compared to that observed in white blood cell (WBC) lysates of the same animals. The WBC-associated RNase activity directed against polyuridylic acid decreased with the progression of neoplastic disease, though serum RNase activity remained unchanged. With certain forms of cancer, therefore, variations in cell RNase may be more sensitive markers than changes in serum RNase for the evaluation of the progression or regression of disease.
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
Authors: Emilio P. Mottillo, Eric M. Desjardins, Justin D. Crane, Brennan K. Smith, Alex E. Green, Serge Ducommun, Tora I. Henriksen, Irena A. Rebalka, Aida Razi, Kei Sakamoto, Camilla Scheele, Bruce E. Kemp, Thomas J. Hawke, Joaquin Ortega, James G. Granneman, Gregory R. Steinberg
Journal: Cell Metabolism (2016)
Acupuncture treatment of schizophrenia: report on three cases
Authors: J Kane, W J Di Scipio
Journal: American Journal of Psychiatry (1979)

The authors conducted a 9-week blind controlled study of the effects of acupuncture on schizophrenic illness in three patients on an inpatient ward of a psychiatric hospital. This paitents were used as their own controls. The authors compared the effects of acupuncture, pseudo-acupuncture (random needling), and no treatment control periods. Two patients who had had florid schizophrenic symptoms responded positively to true acupuncture treatment and negatively to pseudo-acupuncture. The third patient, whose symptoms were primarily affective-depressive, showed no significant response to treatment. The authors explore the mechanisms thought to be involved in the etiology of schizophrenia, focusing on the cortical arousal hypothesis.
Update On The Long-Term Efficacy and Safety Of Momelotinib, a JAK1 and JAK2 Inhibitor, For The Treatment Of Myelofibrosis
Authors: Animesh Pardanani, Jason Gotlib, Vikas Gupta, Andrew W. Roberts, Martha Wadleigh, Shireen Sirhan, Linda M Bavisotto, Jun Kawashima, Peter Lee, Mark Kowalski, Wei Deng, Demi Niforos, Ayalew Tefferi
Journal: Blood (2013)
Next-Generation Sequencing and Result Interpretation in Clinical Oncology: Challenges of Personalized Cancer Therapy
Authors: Yekaterina B. Khotskaya, Gordon B. Mills, Kenna R. Mills Shaw
Journal: Annual Review of Medicine (2016)

The tools of next-generation sequencing (NGS) technology, such as targeted sequencing of candidate cancer genes and whole-exome and -genome sequencing, coupled with encouraging clinical results based on the use of targeted therapeutics and biomarker-guided clinical trials, are fueling further technological advancements of NGS technology. However, NGS data interpretation is associated with challenges that must be overcome to promote the techniques' effective integration into clinical oncology practice. Specifically, sequencing of a patient's tumor often yields 30–65 somatic variants, but most of these variants are “passenger” mutations that are phenotypically neutral and thus not targetable. Therefore, NGS data must be interpreted by multidisciplinary decision-support teams to determine mutation actionability and identify potential “drivers,” so that the treating physician can prioritize what clinical decisions can be pursued in order to provide cancer therapy that is personalized to the patient and his or her unique genome.
Resolving Misconceptions About Liver Allocation and Redistricting Methodology
Authors: Sommer E. Gentry, Ryutaro Hirose, David Mulligan
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Pulmonary oxygen toxicity
Authors: L H Brown
Journal: JAMA (1971)

Dr. David Ortbals, Intern in Medicine, the Jewish Hospital of St. Louis, and Assistant in Medicine, Washington University School of Medicine: A 45-year-old woman was admitted to Jewish Hospital with a complaint of pain in the back and leg for nine months. Approximately six months earlier she had been hospitalized elsewhere for this complaint, but no abnormalities were found and she received symptomatic therapy. The pain in the back gradually increased and extended into the entire right leg in association with severe weakness of the lower part of the right limb. The patient's past medical history had been normal. Physical examination revealed a well-developed, obese, white woman with normal vital signs. Examination of the head, neck, chest, and abdomen was unremarkable. There was a firm, nontender mass, 5X15 cm in size, along the right side of the spine in the lumbar region. Neuromuscular examination showed weakness of dorsiflexion on the
Case 20-1974
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Paul C. Kahn, James J. Galdabini
Journal: New England Journal of Medicine (1974)

Presentation of CaseA 66-year-old man was admitted to the hospital because of a question of an abdominal aortic aneurysm.He was well until two years previously, when he was admitted to another hospital because of an acute myocardial infarct. Obesity and hypercholesterolemia were noted; a diet was prescribed, and he lost weight. He experienced infrequent episodes of chest pain thereafter, without congestive symptoms. Two and a half months before admission there was the onset of episodic sharp mid-abdominal pain that radiated to the back, persisted for several hours at a time and recurred every three or four days. The . . .
Clinical and Genetic Features of Patients With <i>TNFRSF1A</i> Variants in Japan: Findings of a Nationwide Survey
Authors: Naoyasu Ueda, Hiroaki Ida, Masakazu Washio, Hisaaki Miyahara, Shoji Tokunaga, Fumiko Tanaka, Hiroki Takahashi, Koichi Kusuhara, Koichiro Ohmura, Manabu Nakayama, Osamu Ohara, Ryuta Nishikomori, Seiji Minota, Shuji Takei, Takao Fujii, Yoshiaki Ishigatsubo, Hiroshi Tsukamoto, Tomoko Tahira, Takahiko Horiuchi
Journal: Arthritis & Rheumatology (2016)

To elucidate the clinical and genetic features of patients with TNFRSF1A variants in Japan using data obtained from a nationwide survey conducted by the Ministry of Health, Labor, and Welfare of Japan study group for tumor necrosis factor receptor-associated periodic syndrome (TRAPS).Inquiries were sent to 2,900 departments of internal medicine and pediatrics in all hospitals with more than 200 beds in Japan, asking whether they had patients in whom TRAPS was suspected. Genetic tests for TNFRSF1A, MEFV, and MVK were performed on 169 patients. Cell surface expression of TNFRSF1A variants was assessed using 293T cells.Ten patients from 10 independent families were found to have TNFRSF1A variants. We collected clinical and genetic information on 41 additional patients with TNFRSF1A variants and symptoms of inflammation from 23 independent families; 17 of these patients had not been described in the literature. The common clinical features of Japanese patients were fever of >38°C (100% of patients), arthralgia (59%), and rash (55%). The prevalence of abdominal pain (36%), myalgia (43%), and amyloidosis (0%) was significantly lower in Japanese patients than in Caucasian patients. The most common variant was T61I (appearing in 49% of patients), and it was identified in 7 of 363 healthy controls. Defects in cysteine residues and the T50M variant were associated with decreased cell surface expression, while other variants, including T61I, were not.Patients with TNFRSF1A variants are very rare in Japan, as in other countries, but there are a number of clinical and genetic differences between Japanese and Caucasian patients. The pathogenic significance of the T61I variant remains unclear.
Management of breast cancer: limited mastectomy
Authors: G. Crile
Journal: JAMA (1974)

INTRODUCTION My stand on the treatment of breast cancer has been misunderstood widely.. Many surgeons believe that I advocate what the British call “lumpectomy” and irradiation. Nothing could be further from the truth. I do, however, stand firmly against the traditional radical mastectomy. I consider it to be archaic, and I believe that it has no place in the modern treatment of breast cancer. I strongly support modified radical mastectomy. It is indicated primarily for a patient who has palpable involvement of a few low or central axillary nodes at the time of operation. If the involvement is extensive, however, and particularly if the nodes at the apex are palpably involved, I argree with Haagensen’ that the apex of the axilla should not be dissected. It is better to rely on irradiation alone to control the cancer in the apical, supraclavicular, and internal mammary nodes, because the combination of complete axillary dissection and irradiation is apt to result in severe lymphedema of the arm.
Utilization of Amino Acids, Peptides, and Protein by Cultures of Embryonic Heart&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Winnick, Ruth E., Winnick, Theodore
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Utilization of Amino Acids, Peptides, and Protein by Cultures of Embryonic Heart Get access Ruth E. Winnick, Ruth E. Winnick Department of Biochemistry and the Radiation Research Laboratory, State University of Iowa, Iowa City, Iowa Search for other works by this author on: Oxford Academic PubMed Google Scholar Theodore Winnick Theodore Winnick Department of Biochemistry and the Radiation Research Laboratory, State University of Iowa, Iowa City, Iowa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 519–525, https://doi.org/10.1093/jnci/14.3.519 Published: 01 December 1953 Article history Received: 30 June 1953 Published: 01 December 1953
GPs in England and Scotland are reluctant to use email consultations, survey finds
Authors: Susan Mayor
Journal: BMJ (2016)

Fewer than one in 10 general practices in England and Scotland use email consultations with patients, and more than half have no plans to introduce them, a survey has shown.1

Asking about alternatives to face to face consultations, researchers sent the survey to each of the GPs and practice managers at 421 practices around Bristol and Oxford in England and in Lothian, the Highlands, and the Western Isles in Scotland. These areas were …
UNC13D and PRF1 Mutations in Childhood Patients with Hemophagocytic Lymphohistiocytosis.
Authors: Udo zur Stadt, Karin Beutel, Florian Oyen, A. Sarper Diler, Hartmut Kabisch, Reinhard Schneppenheim, Hans-Christian Hennies, Gritta Janka
Journal: Blood (2004)
Value of the Preoperative Detection of Prostate-Specific-Antigen-Positive Circulating Cells by Nested RT-PCR in Patients Submitted to Radical Prostatectomy
Authors: P de Cremoux, V Ravery, M P Podgorniak, S Chevillard, M Toublanc, N Thiounn, R Tatoud, V Delmas, T Calvo, L Boccon-Gibod
Journal: European Urology (1997)
S12 Efficacy of bronchial thermoplasty in clinical practice using the British Thoracic Society UK Difficult Asthma Registry and Hospital Episode Statistics: Abstract S12 Table 1
Authors: J Burn, AJ Sims, K Keltie, H Patrick, S Welham, RM Niven, LG Heaney
Journal: Thorax (2015)

<h3>Introduction and objectives</h3> NICE Guidance encourages further research on the efficacy of bronchial thermoplasty (BT). This study uses data from the British Thoracic Society (BTS) UK Difficult Asthma Registry (DAR) and the Hospital Episodes Statistics (HES) database to assess aspects of efficacy and compares these with previous trials. <h3>Methods</h3> Lung function (FEV<b><sub>1</sub></b>), quality of life (AQLQ), rescue steroid use, healthcare visits and days lost from work/school were compared at BT baseline and 12 month follow-up in patients for whom DAR data were available. In calculating annualised figures, baseline data were assumed to represent 12 months pre-BT, and 12 month follow-up data were scaled according to the time period that the follow-up represented. Significance testing for differences in FEV<b><sub>1 </sub></b>and AQLQ used a paired t-test. Differences in event counts were tested using non-parametric bootstrap hypothesis tests. HES was searched for BT episodes from 1<sup>st</sup> April 2011 to 31<sup>st</sup> January 2015. An anonymised matching technique was used to link patients in HES and DAR, and for those whom sufficient time had elapsed since BT, HES A&amp;E attendances were compared in the 12 months pre-BT and the 12 months starting from 30 days post-BT (to exclude any transient increases). <h3>Results</h3> 31 patients had 12 month follow-ups in DAR, enabling comparison with BT baseline where data were available. All outcomes from DAR showed improvement at 12 month follow-up compared to BT baseline (Table 1). The mean improvement in AQLQ score (0.92) was smaller than that reported in AIR2 (1.35; n = 190), AIR (1.3; n = 52) and RISA (1.53; n = 15) trials. From HES, there were 24 A&amp;E attendances (in 5/12 patients) in the 12 months pre-treatment and 15 A&amp;E attendances (in 6/12 patients) in the 12 months post-treatment. <h3>Conclusion</h3> To date, efficacy outcomes appear consistent with those observed in previous clinical trials, with a smaller, but statistically significant, improvement in AQLQ score. The reduction in unscheduled healthcare visits and days lost from work/school also reached statistical significance. Although the median number of A&amp;E attendances increased in the 12 patients studied, the annual rate of A&amp;E attendances per patient reduced from 2 to 1.25.
Association Between Gun Law Reforms and Intentional Firearm Deaths in Australia, 1979-2013
Authors: Simon Chapman, Philip Alpers, Michael Jones
Journal: JAMA (2016)

Rapid-fire weapons are often used by perpetrators in mass shooting incidents. In 1996 Australia introduced major gun law reforms that included a ban on semiautomatic rifles and pump-action shotguns and rifles and also initiated a program for buyback of firearms.To determine whether enactment of the 1996 gun laws and buyback program were followed by changes in the incidence of mass firearm homicides and total firearm deaths.Observational study using Australian government statistics on deaths caused by firearms (1979-2013) and news reports of mass shootings in Australia (1979-May 2016). Changes in intentional firearm death rates were analyzed with negative binomial regression, and data on firearm-related mass killings were compared.Implementation of major national gun law reforms.Changes in mass fatal shooting incidents (defined as ≥5 victims, not including the perpetrator) and in trends of rates of total firearm deaths, firearm homicides and suicides, and total homicides and suicides per 100,000 population.From 1979-1996 (before gun law reforms), 13 fatal mass shootings occurred in Australia, whereas from 1997 through May 2016 (after gun law reforms), no fatal mass shootings occurred. There was also significant change in the preexisting downward trends for rates of total firearm deaths prior to vs after gun law reform. From 1979-1996, the mean rate of total firearm deaths was 3.6 (95% CI, 3.3-3.9) per 100,000 population (average decline of 3% per year; annual trend, 0.970; 95% CI, 0.963-0.976), whereas from 1997-2013 (after gun law reforms), the mean rate of total firearm deaths was 1.2 (95% CI, 1.0-1.4) per 100,000 population (average decline of 4.9% per year; annual trend, 0.951; 95% CI, 0.940-0.962), with a ratio of trends in annual death rates of 0.981 (95% CI, 0.968-0.993). There was a statistically significant acceleration in the preexisting downward trend for firearm suicide (ratio of trends, 0.981; 95% CI, 0.970-0.993), but this was not statistically significant for firearm homicide (ratio of trends, 0.975; 95% CI, 0.949-1.001). From 1979-1996, the mean annual rate of total nonfirearm suicide and homicide deaths was 10.6 (95% CI, 10.0-11.2) per 100,000 population (average increase of 2.1% per year; annual trend, 1.021; 95% CI, 1.016-1.026), whereas from 1997-2013, the mean annual rate was 11.8 (95% CI, 11.3-12.3) per 100,000 (average decline of 1.4% per year; annual trend, 0.986; 95% CI, 0.980-0.993), with a ratio of trends of 0.966 (95% CI, 0.958-0.973). There was no evidence of substitution of other lethal methods for suicides or homicides.Following enactment of gun law reforms in Australia in 1996, there were no mass firearm killings through May 2016. There was a more rapid decline in firearm deaths between 1997 and 2013 compared with before 1997 but also a decline in total nonfirearm suicide and homicide deaths of a greater magnitude. Because of this, it is not possible to determine whether the change in firearm deaths can be attributed to the gun law reforms.
Bortezomib Treatment Sensitizes Oncolytic HSV-1–Treated Tumors to NK Cell Immunotherapy
Authors: Ji Young Yoo, Alena Cristina Jaime-Ramirez, Chelsea Bolyard, Hongsheng Dai, Tejaswini Nallanagulagari, Jeffrey Wojton, Brian S. Hurwitz, Theresa Relation, Tae Jin Lee, Michael T. Lotze, Jun-Ge Yu, Jianying Zhang, Carlo M. Croce, Jianhua Yu, Michael A. Caligiuri, Matthew Old, Balveen Kaur
Journal: Clinical Cancer Research (2016)

Both the proteasome inhibitor bortezomib and an oncolytic herpes simplex virus-1 (oHSV)-expressing GM-CSF are currently FDA approved. Although proteasome blockade can increase oHSV replication, immunologic consequences, and consequent immunotherapy potential are unknown. In this study, we investigated the impact of bortezomib combined with oHSV on tumor cell death and sensitivity to natural killer (NK) cell immunotherapy.