tbuckley/cabot-search huggingface dataset:
AB0109 Increased Subchondral Bone Resorption in the Absence of Osteoarthritis in a Mtdna Mutator Mouse Model of Premature Aging
Authors: J. Geurts, P. Distel, M. Müller-Gerbl, T.A. Prolla, G. Kujoth, U.A. Walker, T. Hügle
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Age is the most prominent risk factor for osteoarthritis and mitochondrial DNA dysfunction has been repeatedly described in human osteoarthritic chondrocytes. Mice expressing a proofreading-deficient mitochondrial DNA polymerase (POLG) mutant accumulate an excess of reactive oxygen species and apoptosis and develop a premature aging phenotype. While these mice display a reduction in bone density, it is unclear whether they are more prone to developing osteoarthritis. <h3>Objectives</h3> In this study, we assessed the histomorphometric properties of subchondral bone and cartilage tissues in premature aging mice. <h3>Methods</h3> Mice carrying heterozygous (wt/mut <i>n=</i>5) or homozygous (mut/mut <i>n=</i>4) D257A mutations in POLG were compared with wildtype littermates (wt <i>n</i>=7). Animals were aged between eleven and fifteen months. Sagittal histological sections from knee joints were stained with Safranin-<i>O</i>/Fast Green and cartilage degeneration was assessed using OARSI scores. Subchondral bone area fraction (B.Ar/T.Ar) and osteoclast numbers (Oc.N/mm perimeter) between epiphyses and articular cartilage was determined on tissues stained for tartrate-resistant acid phosphatase (TRAP) and methylene blue using bone histomorphometric analyses. <h3>Results</h3> Wild type mice revealed only low grade cartilage degeneration (OARSI score &lt;1), predominantly loss of cartilage proteoglycans. OARSI scores were found to be equally low in wt/mut and mut/mut mice, showing no statistical differences between groups. Notably, subchondral bone area fraction was significantly decreased in mut/mut (0.20±0.1) compared with wt/mut (0.42±0.03) and wt (0.45±0.04) animals. Correspondingly, Oc.N per mm subchondral bone surface were strongly increased (<i>p</i>&lt;0.05) between mut/mut (0.88±0.30) and wt/mut (0.25±0.03) and wt (0.12±0.04) mice. <h3>Conclusions</h3> Mice with premature aging due to accumulation of mtDNA mutations display increased bone remodelling favouring subchondral bone resorption. Additional biomechanical factors might be required in this premature aging phenotype for development of osteoarthritis. <h3>Disclosure of Interest</h3> None declared
Surgeon's clinical valuation and accuracy of ultrasound in the diagnosis of acute appendicitis: A comparison with intraoperative evaluation. Five years experience
Authors: Alessia Ferrarese, Alessandro Falcone, Mario Solej, Dario Bono, Paolo Moretto, Najada Dervishi, Veltri Andrea, Stefano Enrico, Mario Nano, Valter Martino
Journal: International Journal of Surgery (2016)
The Unrelenting Challenge of Obesity
Authors: Jody W. Zylke, Howard Bauchner
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ga-67 uptake in ischemic enteritis in a patient with Churg-Strauss syndrome.
Authors: H Ohta, M Shintaku, K Iwaisako, A Arimoto, Y Nakashima, M Ukikusa
Journal: Clinical Nuclear Medicine (2001)

OHTA, HITOYA M.D.,*; SHINTAKU, MASAYUKI M.D.,†; IWAISAKO, KEIKO M.D.,‡; ARIMOTO, AKIRA M.D.,‡; NAKASHIMA, YASUO M.D.‡ AND; UKIKUSA, MINORU M.D.‡ Author Information
Antiemetic-induced akathisia in cancer patients receiving chemotherapy
Authors: S B Fleishman, M R Lavin, M Sattler, H Szarka
Journal: American Journal of Psychiatry (1994)

A structured, prospective telephone interview was used to assess the prevalence of akathisia in 24 cancer patients receiving metoclopramide or prochlorperazine during or after chemotherapy. Half of the patients reported subjective motor restlessness, and 75% stated that they would not have informed staff. This report suggests that akathisia is frequently unrecognized in chemotherapy patients receiving metoclopramide and prochlorperazine.
Ongoing outbreak of aseptic meningitis associated with echovirus type 30 in the City of Novi Sad, Autonomous Province of Vojvodina, Serbia, June – July 2010
Authors: G Ćosić, P Đurić, V Milošević, J Đekić, G Čanak, V Turkulov
Journal: Eurosurveillance (2010)

Since June 2010, incidence of aseptic meningitis has increased in Novi Sad, Autonomous Province of Vojvodina, Serbia. From 2 June to 25 July 2010, 80 cases of aseptic meningitis were notified, with an incidence rate ranging from 10 to 366 per 100,000 population in different local communities. The majority of cases (n=64) were aged between two and 15 years. Echovirus 30 was cultured from two of four cerebrospinal fluid specimens. The outbreak, for which no common source has yet been identified, is ongoing.
Rachel Clark and colleagues reply to Eleanor Barry and colleagues
Authors: Rachel Clark, Jonathan Valabhji, Alison Tedstone, Louise Ansari, Jim O’Brien
Journal: BMJ (2015)

Eleanor Barry and colleagues’ editorial relays their concerns about the NHS Diabetes Prevention Programme (DPP).1 Key concerns are dealt with here. The NHS DPP will offer people already identified as being at high risk of developing type 2 diabetes an opportunity to lower their risk through provision of an evidence based behavioural intervention. By failing to implement such a programme, people with known non-diabetic hyperglycaemia are deprived of consistent and evidence based support that would empower them to reduce their risk of type 2 diabetes, questioning our commitment to the public’s health and wellbeing.

We agree that there is a need for multi-level action. Both NHS England and Public Health England (PHE) published plans last year with a focus on improving diet, increasing levels of physical activity, …
Lymphogranuloma venereum emerging in men who have sex with men in Germany
Authors: V Bremer, T Meyer, U Marcus, O Hamouda
Journal: Eurosurveillance (2006)

A resurgence of lymphogranuloma venereum (LGV) has been observed in several European countries. LGV is not a mandatorily notifiable disease in Germany. Reports of LGV cases have actively been collected by the Robert Koch-Institut since 2004 to describe the outbreak and estimate the extent of the LGV problem in Germany. Updates on the LGV outbreak were published in the German national epidemiological bulletin. Physicians were asked to send their samples to a laboratory for genotyping. A possible case was defined as a person with symptoms of proctitis and/or inguinal lymph node swelling and a positive chlamydia serology. A probable case had in addition a positive chlamydia rectal or urinary PCR test. A case was confirmed if the genotype L1-L3 was identified based on sequence analysis of omp1 gene sequences. Since 2003, LGV has been reported in 78 male patients in Germany. Of these, 61 patients were confirmed as genotype L2. Fifty eight out of 78 patients (74%) are known to be men who have sex with men (MSM). Fifty five patients (71%) had rectal symptoms and 49 (63%) knew they were HIV positive. Sixty two (79%) of the patients were residents of Berlin or Hamburg. LGV has emerged in MSM in Germany at the same time as in other European countries. It is thought that LGV may become endemic in the MSM community in German metropolitan areas, because the number of reported patients with LGV continues to increase. The increase in the number of LGV cases and the high HIV prevalence in LGV patients are of great public health concern. Clinicians and MSM may not be sufficiently aware of the disease, and existing efforts to promote awareness and prevention of sexually transmitted infections and HIV need to be strengthened.
Surveillance of communicable diseases among the Kosovar refugees in Albania, April-June 1999
Authors: M Valenciano, A Pinto, D Coulombier, E Hashorva, M Murthi
Journal: Eurosurveillance (1999)

Albania, a country with 3.5 million inhabitants, is facing an economic and social crisis. The average per capita income is less than US$1000 per year. Since 1995 unemployment has increased by 2.7%. Poverty and migration are major constraints of the societ
pH‐Switch Nanoprecipitation of Polymeric Nanoparticles for Multimodal Cancer Targeting and Intracellular Triggered Delivery of Doxorubicin
Authors: Bárbara Herranz‐Blanco, Mohammad‐Ali Shahbazi, Alexandra R. Correia, Vimalkumar Balasubramanian, Tomáš Kohout, Jouni Hirvonen, Hélder A. Santos
Journal: Advanced Healthcare Materials (2016)

Theranostic nanoparticles are emerging as potent tools for noninvasive diagnosis, treatment, and monitoring of solid tumors. Herein, an advanced targeted and multistimuli responsive theranostic platform is presented for the intracellular triggered delivery of doxorubicin. The system consists of a polymeric-drug conjugate solid nanoparticle containing encapsulated superparamagnetic iron oxide nanoparticles (IO@PNP) and decorated with a tumor homing peptide, iRGD. The production of this nanosystem is based on a pH-switch nanoprecipitation method in organic-free solvents, making it ideal for biomedical applications. The nanosystem shows sufficient magnetization saturation for magnetically guided therapy along with reduced cytotoxicity and hemolytic effects. IO@PNP are largely internalized by endothelial and metastatic cancer cells and iRGD decorated IO@PNP moderately enhance their internalization into endothelial cells, while no enhancement is found for the metastatic cancer cells. Poly(ethylene glycol)-block-poly(histidine) with pH-responsive and proton-sponge properties promotes prompt lysosomal escape once the nanoparticles are endocyted. In addition, the polymer-doxorubicin conjugate solid nanoparticles show both intracellular lysosomal escape and efficient translocation of doxorubicin to the nuclei of the cells via cleavage of the amide bond. Overall, IO@PNP-doxorubicin and the iRGD decorated counterpart demonstrate to enhance the toxicity of doxorubicin in cancer cells by improving the intracellular delivery of the drug carried in the IO@PNP.
Case 37-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Donald E. Craven, Eugene J. Mark
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 50-year-old man was admitted to the hospital because of bilateral pneumonia and respiratory failure.He was well until two weeks previously, in early October, when coryza, a nonproductive cough, and myalgia developed and subsided after a few days, with a return to his base line of a mild, chronic daily cough. One week before entry a prominent dry cough recurred abruptly, followed by pleuritic pain in the left side of the chest, dyspnea, and repeated shaking chills. The cough persisted, and malaise, anorexia, and nausea developed; the patient vomited once. The temperature rose to 39.4°C. Five . . .
SAT0291 Clinical Relevance of FGF-23 in Dialysis Tunisian Patients
Authors: M. Slouma, H. Sahli, S. Rekik, L. Laadhar, W. Smaoui, S. Boussaid, A. Bahlous, E. Cheour, F. Ben Moussa, M. Sallami, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Fibroblast growth factor-23 (FGF23) is a bone-derived hormone. The association between FGF-23 levels and clinical outcome in hemodialysis patients suggests that FGF-23 can be considered as a cardiovascular risk in this population, Moreover, relationship between FGF-23 and osteoporosis remains unclear in dialysis patients. <h3>Objectives</h3> The aim of the study was to demonstrate the association between FGF-23 levels with either osteoporosis and cardiovascular risk factors in hemodialysis patients. <h3>Methods</h3> We conducted a transversal study over a period of 4 years [2009-2012] including 80 patients under hemodialysis therapy over one year period. Blood samples were drawn before hemodialysis session from patients. We measured calcium, phosphate, 25 OH-vitamin D and fibroblast growth factor (FGF23). Bone mass density (BMD) was measured by dual energy X-ray absorptiometry (DXA) at the lumbar spine and total hip. Lumbar spine X-rays were used to diagnose vascular calcification. All statistical analysis were performed using the Windows SPSS 19 package. <h3>Results</h3> Eighty patients were included: 51 male and 29 female. The mean age was 53.27 years [20; 89]. The mean age of onset of hemodialysis was 50.42±14.49 years. The mean body mass index (BMI) was 25.91±4.86 kg/m<sup>2</sup> and the mean weight was 68.16±13.36 kg. Diabetes, hypertension and dyslipidemia were observed respectively in 45%, 66.3% and 15% of cases. Serum calcium and phosphorus levels were respectively 2.06±0.39 mmol/L and 1.83±0.57 mmol/L. The average rates of parathyroid hormone (PTH), vitamin D and FGF23 were respectively 422.60±382.8 pg/mL 15.92±11.39 ng/mL, and 248.96±221.87 pg/mL. Osteoporosis affected the hip in 20% of cases and the spine in 9% whereas osteopenia was observed in 44% of cases in the hip and 33% of cases in the spine lumbar. Vascular calcifications (CV) were found in 31.11% of cases. Negative correlation was observed between FGF23 and vitamin D (r: -0.245, p: 0.027). Patients with dyslipidemia had higher FGF23 levels than patients without dyslipidemia (239.28 pg/mL vs 123.19pg/mL). No correlation was found between FGF23 and following parameters: calcium and phosphorus levels, PTH levels, BMI and weight. FGF levels 23 tend to be higher in hemodialysis with CV but this difference was not significant (275.85 pg/mL vs 195.88 pg/mL, p:0.231). Lumbar osteoporosis was associated with high concentrations of FGF23. <h3>Conclusions</h3> Our study showed that FGF-23 levels are increased in hemodialysis patients. We demonstrate also that higher concentrations of FGF23 are associated with osteoporosis in lumbar spine. Given the association FGF23 and dyslipidemia, this factor can be considered as a cardiovascular risk in hemodialysis patients. <h3>Disclosure of Interest</h3> None declared
Disparities in utilization of breast-conserving therapy among breast cancer patients.
Authors: Meeghan Ann Lautner, Heather Y. Lin, Yu Shen, Catherine Parker, Henry Mark Kuerer, Simona Flora Shaitelman, Gildy Babiera, Isabelle Bedrosian
Journal: Journal of Clinical Oncology (2014)

104 Background: Since 1990 breast conserving therapy (BCT) has become a widely accepted modality in the treatment of breast cancer. However, many women continue to undergo mastectomy over BCT. The objective of this study was to provide a comprehensive population based review of the factors that influence utilization of BCT. Methods: Using the National Cancer Database (NCDB), we evaluated women who underwent a mastectomy or BCT for T1/T2, any N breast cancer between 1998 and 2011. We conducted a retrospective review of patient and facility variables associated with undergoing BCT and the trends over time. Logistic regression analysis was used to assess the multivariate relationship between these variables and the probability of undergoing BCT. Results: Among the 727,927 patients who met study criteria, BCT rates increased from 54% in 1998 to 59% in 2006 and then stabilized. After adjusting for demographic and clinical characteristics, BCT utilization was more likely in patients aged 52-61 compared to younger patients (odds ratio (OR) 1.14 {95% CI 1.12-1.15}) and in those with the highest education level (OR 1.16 {95% CI 1.14-1.19}). BCT rates were higher in patients with private insurance compared to the uninsured (OR 1.33 {95% CI 1.28-1.38}) and in those with the highest median income (OR 1.09 {95% CI 1.06-1.11}) (all p &lt; 0.0001). Academic Cancer Programs, facilities in the Northeast and patients who lived within 17 miles of a treatment facility had higher utilization of BCT than Community Cancer Programs (OR 1.13 {95% CI 1.11-1.15}), facilities located in the South (OR 1.50 {95% CI 1.48-1.52}) and those who lived further from a treatment facility (OR 1.25 {95% CI 1.23-1.27}) (all p&lt;0.0001). When comparing BCT utilization in 1998 and 2011, increases were seen across age groups, in community cancer programs and in facilities located in the South; however, disparities by insurance status, income level and travel greater than 17 miles to a treatment facility persist. Conclusions: BCT rates have increased during the last two decades. Disparities based on age, geographic location and type of cancer program have improved. However, socio-economic status and travel distance to treatment facilities persist as key barriers to BCT utilization.
THU0635-HPR Do Physiotherapists Working in New Patient Rheumatology Clinics Miss Inflammatory Arthritis: A Retrospective Review of 296 Patients
Authors: P.D. Kirwan, T. Duffy
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Physiotherapists working in triage roles are well established in orthopaedic and spinal clinics, but there is less literature available on their role in rheumatology. We have shown previously that a physiotherapist can diagnose inflammatory arthritis with an accuracy of 89% (Kirwan and Duffy, 2014). <h3>Objectives</h3> This audit set out to ascertain whether a physiotherapist working in a rheumatology new patient clinic, as a first point of contact clinician, misses inflammatory arthritis. <h3>Methods</h3> Data was collected consecutively on all patients assessed by the Physiotherapist at the Rheumatology New Patient Clinic from December 2010 to June 2014. Patients who were diagnosed with an inflammatory condition were omitted from this review. The remaining patients were given non-inflammatory diagnoses. Medical charts were reviewed to establish whether any of these patients subsequently developed an inflammatory arthritis. <h3>Results</h3> A total of 294 patients were assessed over the time period. 233 patients were diagnosed with a non-inflammatory condition. Seven charts were unavailable at time of review. Of the 226 charts reviewed, <i>none of these patients had developed an inflammatory arthritis</i>. This review did not set out to establish if this group had resolution of their presenting complaint but instead focused on whether any patients presenting with non-inflammatory symptoms were misdiagnosed by the Physiotherapist. Over a 3 and a half year period and upon completing assessments on 294 patients, our previous study (Kirwan and Duffy, 2014) revealed the Physiotherapist displayed high accuracy when diagnosing inflammatory joint disease. This review highlighted that the Physiotherapist did not miss inflammatory arthritis upon assessment and diagnosis of 226 patients with non-inflammatory conditions. <h3>Conclusions</h3> This study highlights the high number of non-inflammatory conditions (79%) seen in a new patient rheumatology clinic. Patients presented with a wide spectrum of symptoms indicating a range of clinical assessments skills are required. The data indicate that a physiotherapist with specialist training in rheumatology does not miss inflammatory arthritis, and can safely and effectively assess inflammatory (Kirwan and Duffy, 2014) and non-inflammatory conditions, while working in a new patient rheumatology clinic. The findings from this review confirm the value, and benefit, in having a physiotherapist present in rheumatology new patient clinics, to assist in diagnosing and managing the large number of mechanical/degenerative conditions seen. <h3>References</h3> Kirwan P, Duffy T. Physiotherapist9s accuracy in recognizing and diagnosing inflammatory joint disease while working in a new patient rheumatology clinic. (Abstract). In: Ann Rheum Dis 2014;73(Suppl2); 2014 Jun 11-14; Paris, France. <h3>Disclosure of Interest</h3> None declared
INTERNATIONAL LEPROSY ASSOCIATION
Authors: A O'BYRNE
Journal: British Journal of Dermatology (1931)

British Journal of DermatologyVolume 43, Issue 5 p. 257-258 INTERNATIONAL LEPROSY ASSOCIATION First published: May 1931 https://doi.org/10.1111/j.1365-2133.1931.tb09499.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume43, Issue5May 1931Pages 257-258 RelatedInformation
Expenditures for psychotropic medications in the United States in 1985
Authors: J J Zorc, D B Larson, J S Lyons, R S Beardsley
Journal: American Journal of Psychiatry (1991)

Psychotropic medications have seldom been included in estimates of the costs of mental health services. In the infrequent case that these costs have been assessed, they have been estimated by using national surveys of consumers of health services. The objective of this study was to estimate the costs of prescriptions for psychotropic medications in the United States in 1985 and to assess the difference with the most recent cost estimate from a health services survey (1977).Study data were based on retail costs of psychotropic medications reported to the Pharmaceutical Data Service Alpha National Prescription and Sales Audit. The data come from a computerized survey panel of 2,250 pharmacies representative of the more than 14,000 pharmacies nationwide. The database includes all medication prescriptions filled, whether paid with cash or Medicaid or reimbursed by third-party payment. Analyses were limited to psychotropic medication prescriptions.In 1985, $1.45 billion was spent on outpatient psychotropic medications. Nearly $868 million (60% of the total) was spent on antianxiety and sedative-hypnotic medications, while approximately $263 million (18%) was spent on antipsychotic medications, $240 million (17%) on antidepressants, and $84 million (5%) on combination psychotropic medications. These expenditures were much higher than would have been expected given the most recent health services estimate of $513 million.These results demonstrate the substantial cost of psychotropic medications in 1985. The finding that the cost of psychotropic medications was so high, in contrast to the lower estimate from the 1977 survey, demonstrates the importance of obtaining more frequent cost estimates and basing future estimates on medication databases.
Drug induced parkinsonism
Authors: O S Levin, N N Shindriaeva, M A Anikina
Journal: BMJ (1986)

reported in France and Australia,'2 and 20 Australian subjects said that they used dextromethorphan because they experienced increased perceptual awareness, altered time perception, and visual hallucinations.3We believe that the potential for psychotropic effects of this drug is not fully appreciated and that its abuse may be more widespread than previously recognised.1 Dodds A, Reval E. Toxic psychosis due to dextromethorphan.