tbuckley/cabot-search huggingface dataset:
AB0909 Bone Impact of Metabolic Syndrome in Postmenopausal Women
Authors: S. Talbi, N. Aradoin, H. Azzouzi, J. Essouiri, F. Lazrak, F.E. Abourazzak, T. Harzy
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The data concerning the association between metabolic syndrome (MS) and the bone is limited and conflicting <h3>Objectives</h3> The aim of our study was to evaluate the difference in bone mineral density in postmenopausal women with and without MS, and identify the components of this syndrome affecting most the bone mineral density. <h3>Methods</h3> This is a cross-sectional study conducted in the department of rheumatology of Hassan II University Hospital, Fez, Morocco. All patients benefited from Bone densitometry measured by DXA. A lipid levels, carbohydrate, calcium phosphate, and the dosage of 25 (OHvit D2 and D3) were measured. Metabolic syndrome was assessed according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Statistical analysis was done using using SPSS v18 softwar. A univariate regression analysis and a logistic regression was used to identify the metabolic syndrome factors influencing bone mineral density. <h3>Results</h3> 170 postmenopausal patients were included, 81 with and 89 without syndorme metaboloc. The mean age of patients was 59±6.5 years. The mean age of menopause was 49±6.4 years. The mean BMI was 29.7 kg/cm<sup>2</sup> ±4.1. The vitamin D deficiency was found in 62.7% with a mean of 18.6±8.8 ng/ml. Seventy patients were osteoporotic and osteopenic were seventy-two. The prevalence of metabolic syndrome was 48.5%. The two groups of patients with and without metabolic syndrome differed on the mean age (p=0.05), body mass index (p=0.002), HDL (p&lt;0.001), glucose (p&lt;0.001), triglycerides (p&lt;0.001) and waist (p&lt;0.001) In univariate analysis, no association was found between the presence of metabolic syndrome and lumbar bone mineral density (p=0.36) and at the hip (p=0.29) <h3>Conclusions</h3> This study suggests that metabolic syndrome does not affect the bone mineral density. <h3>Disclosure of Interest</h3> None declared
Case 9-2015: A Man with Personality Changes and Progressive Neurologic Decline
Authors: Bruce L Miller, Bradford C Dickerson
Journal: New England Journal of Medicine (2015)

As described by Lawn, neuroleptic drugs can exacerbate parkinsonian symptoms.In the Case Record that we discussed, the physicians who were involved in the care of the patient carefully considered this potential complication.The patient's severe behavioral disturbance led to the cautious use of neuroleptic drugs.Space constraints precluded further discussion of the challenges involved in behavioral treatment of this patient and the multiple alternative medications that had been tried.Similarly, Lawn's comment that quetiapine and clozapine have fewer extrapyramidal side effects than other antipsychotic drugs is also well accepted.However, in the patient with severe agitation who is a potential threat to himself and others, when these agents (usually considered first-line) fail, there is little empirical evidence to guide the subsequent choice of antipsychotic medications.
Treatment of Latent Syphilis
Authors: H W Jaffe
Journal: New England Journal of Medicine (1964)

The studies in the English language of the treatment of latent syphillis suffer from a variety of problems. Investigators have failed to define cases adequately and, in some instances, have combined results of several treatment regimens, and have not followed patients for an adequate period of time. It may be wisest to recommend that regimens considered effective for asymptomatic neurosyphilis also be used for latent syphilis.
The effects of organizational stress on inpatient psychiatric medication patterns
Authors: A S Gouse
Journal: American Journal of Psychiatry (1984)

The effect of organizational stress on the antipsychotic medication levels of patients was assessed over a 1-year period. Through the use of autocorrelational techniques, medication use was shown to function as a dynamic homeostasis: Continuous adjustments and counter-adjustments resulted in an approximation of equilibrium centering around an idealized dose level. Graphically, these homeostatic oscillations resembled a sinusoidal function with distinct amplitude and periodicity. Organizational stress significantly increased the amplitude of dose level oscillations and shortened the periodicity of each oscillation. Uncontrolled, this situation could lead to a state of extreme overmedication followed sharply by extreme undermedication .
First case of extensively drug-resistant tuberculosis treated with both delamanid and bedaquiline
Authors: Marina Tadolini, Rangjung Dolma Lingtsang, Simon Tiberi, Martin Enwerem, Lia D'Ambrosio, Tsetan Dorji Sadutshang, Rosella Centis, Giovanni Battista Migliori
Journal: European Respiratory Journal (2016)

The European Respiratory Journal has recently discussed delamanid and bedaquiline and their use in difficult-to-treat cases affected by multidrug-resistant tuberculosis (MDR-TB) or extensively drug-resistant (XDR-TB) [1–4]. The use of delamanid or bedaquiline is particularly important when four active drugs cannot be identified and included in a regimen, as per World Health Organization (WHO) guidelines [1–6]. Recently a debate has been initiated around the report of a severe, almost untreatable, XDR-TB case who could not access both new drugs simultaneously [7–10] due to concerns about possible additive toxicity (cardiotoxicity), as well as the lack of evidence and specific guidance on their combined use [10–13]. Report of the first case, concerns and challenges of treatment of severe XDR-TB with both delamanid and bedaquiline <http://ow.ly/WzeB3004Cmo>
On the “Lucke Tumor”Origin of Cell Line LT-1
Authors: Jerome J. Freed, Ph.D., Lorraine H. Toji, Ph.D., Arthur E. Greene, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article On the “Lucke Tumor”Origin of Cell Line LT-1 Get access Jerome J. Freed, Ph.D., Jerome J. Freed, Ph.D. The Institute for Cancer Research Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 Search for other works by this author on: Oxford Academic PubMed Google Scholar Lorraine H. Toji, Ph.D., Lorraine H. Toji, Ph.D. The Institute for Medical Research, Camden, New Jersey 08103 Search for other works by this author on: Oxford Academic PubMed Google Scholar Arthur E. Greene, Ph.D. Arthur E. Greene, Ph.D. The Institute for Medical Research, Camden, New Jersey 08103 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 60, Issue 3, March 1978, Pages 493–495, https://doi.org/10.1093/jnci/60.3.493 Published: 01 March 1978
PWE-356 Solitary intra-abdominal metastasectomy for malignant colorectal cancer; a case series: Abstract PWE-356 Table 1
Authors: H Wright, M Feldman
Journal: Gut (2015)

<h3>Introduction</h3> Patients developing intra-abdominal peritoneal, wound or metachronous lymph node metastases after colorectal cancer surgery have been treated as having inoperable stage IV disease. However modern developments in combination chemotherapy and surgery has led patients with limited liver and lung metastases to have 30% 5 year and 20% 10 year survival.<sup>1</sup>There are no international or national guidelines to assist in the identification of patients who may benefit from an abdominal metastatectomy.<sup>2</sup>This paper reviews the outcomes we have achieved with surgery for patients with a single abdominal metastasis in whom a complete surgical resection is expected. <h3>Method</h3> Our prospective database was searched for patients undergoing surgery for recurrent disease since 2000. Patients having further bowel resection due to anastamotic recurrence, pelvic extenteration (in tertiary units) or excision of Krukenberg tumours were excluded. All patients underwent CT preoperatively, with a 3–6 month period of observation to ensure they did not have rapidly progressive disease and those presenting after 2007 had PET scanning. <h3>Results</h3> 7 patients fulfilled the criteria and underwent surgery with the aim of achieving an R0 resection. <h3>Conclusion</h3> When R0 resection is achieved metastasectomy can be associated with long term survival. With careful patient selection and MDT consideration, surgery to remove isolated metastases should be considered. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Office for National Statistics, Cancer Survival by NHS England Area Team, Adults diagnosed 1997-2012, followed-up 2013, 2014, www.ons.gov.uk Mahmoud N, Dunn KB. Metastasectomy for stage IV colorectal cancer. <i>Dis Colon Rectum</i>. 2010 Jul;53(7):1080-92. doi:10.1007/DCR.0b013e3181dcadbc
Celiac Disease Negatively Influences Lipid Profiles in Young Children With Type 1 Diabetes: Effect of the Gluten-Free Diet
Authors: Silvana Salardi, Giulio Maltoni, Stefano Zucchini, Dario Iafusco, Santino Confetto, Angela Zanfardino, Sonia Toni, Barbara Piccini, Maximiliano Zioutas, Marco Marigliano, Vittoria Cauvin, Roberto Franceschi, Ivana Rabbone, Barbara Predieri, Riccardo Schiaffini, Alessandro Salvatoni, Petra Reinstadler, Giulia Berioli, Valentino Cherubini, Giuseppe d’Annunzio
Journal: Diabetes Care (2016)

The association between low HDL cholesterol (HDL-C) concentrations and increased cardiovascular risk is well established. Low HDL-C levels were found in subjects with type 1 diabetes (T1D) who presented complications (1) and in untreated subjects with celiac disease (CD). The association between TID and CD might therefore enhance this lipid abnormality and accelerate the atherosclerotic process.

We collected data from 13 centers belonging to the Italian Society of Pediatric Endocrinology and Diabetology (ISPED) of a large number of children with both T1D and concurrent biopsy-proven CD, at the exact time point a gluten-free diet (GFD) was initiated and after 1 year of a GFD, verified by means of CD-related antibodies. A total of 201 children with T1D diagnosed at age of 5.8 ± 3.8 years and CD diagnosed at age of 7.5 ± 4.5 years were enrolled. …
OC-057 Anaemia and iron deficiency in adults; how to manage it for nurses. a new guide from the royal college of nursing
Authors: I Mason, D Holloway, K Hurrell, S Johnston, E Whitmore
Journal: Gut (2015)

<h3>Introduction</h3> Iron deficiency anaemia (IDA) is the most common cause of anaemia in primary care and causes &gt;57,000 emergency admissions to hospital/yr at a cost to the NHS of £55.48 m. Effective identification and management is often overlooked. Dealing with IDA prevents complications and blood transfusion use with a cost saving of £8.43 m per year. These guidelines have been developed by expert nurses from relevant specialties. They are aimed at all nurses, health care assistants, midwives and health visitors from all specialties and backgrounds. <h3>Method</h3> The document gives guidance on; identifying IDA and escalating management understanding how IDA occurs, give dietary advice and using oral iron supplements, the use of intravenous iron with practical tips for its delivery.good patient information links. It gives specialist guidance to nurses working in renal disease, gastroenterology, obstetrics and gynaecology and patient blood management. <h3>Results</h3> The main guidance contains; Definition of IDA, iron metabolism and pathophysiology, storage or iron, causes of functional and actual iron deficiency, measuring iron status, common symptoms of anaemia, history taking and examination, dietary iron, oral iron supplements, practical advice for administrating intravenous iron, use of blood transfusion and preoperative optimisation of patients. The GI appendix discusses IDA in coeliac disease and inflammatory bowel disease, and gives case study examples to show the impact of effective nursing intervention on patiient outcomes. <h3>Conclusion</h3> These newly published Royal College of Nursing Guidelines provide an invaluable resource about all areas of iron deficiency management for nurses from all backgrounds and specialties. The specialist appendices provide extra information for nurses working within renal disease, obstetrics and gyanecology, patient blood management and gastroenterology. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Arnott I, Bloom, S, Keshav S, Mowat C, Orchard T, Dalrymple J, Jones R, Saleem S, Fraser A, Mair S, Mason I. Iron deficiency anaemia in inflammatory bowel disease. 2013. Distributed in GUT, Frontline Gastro and BMJ clinical research Derbyshire E. Strategies to improve iron status in women at risk of developing anaemia. Nurs Stand. 2012;26(20):51–57 Goddard AF, James MW, McIntyre AS, Scott BS. Guidelines for the management or iron deficiency anaemia. Gut 2011;60:1309–1316 Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C. <i>UK guideline on the management of iron deficiency in pregnancy</i>. London: BCSH, 2011 Zimmerman MB, Hurrell RF. Nutritional iron deficiency. Lancet 2007;270(9586):511–520
IL-6 Secreted from Cancer-Associated Fibroblasts Mediates Chemoresistance in NSCLC by Increasing Epithelial-Mesenchymal Transition Signaling
Authors: Yasushi Shintani, Ayako Fujiwara, Toru Kimura, Tomohiro Kawamura, Soichiro Funaki, Masato Minami, Meinoshin Okumura
Journal: Journal of Thoracic Oncology (2016)
AB0311 Superiority of Ultrasound over Clinical Examination in Detecting Tenosynovitis in Rheumatoid Arthritis
Authors: W. Hamdi, S. Miladi, I. Cherif, I. Zouch, D. Kaffel, M. Kchir, M. Chelli, F. Ladab
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In rheumatoid arthritis (RA), tendon pathology is a well-recognized, but underestimated aspect of the disease, which may lead to irreversible functional impairment and consequent disability. Clinical joint examination is less time-consuming than ultrasound (US) but it may misdiagnosis tenosynovitis (TS). <h3>Objectives</h3> The aim of this study was to compare clinical assessment of tenosynovitis detection with US examination. <h3>Methods</h3> A cross sectional study was performed including patients followed-up for active recent RA (RA &lt;2 years, DAS28 &gt;2,6). Clinical examination was performed by a rheumatologist seeking signs suggestive of flexor of extensor TS. US was performed by an experienced radiologist blinded to clinical data. All tendons of the hands were scanned in the transverse view from the more proximal to the more distal portion at the tracts surrounded by synovial sheath. Totally 140 hands were assessed. Results of clinical examination were compared to US findings. The difference is considered significant if the P&gt;0,05. <h3>Results</h3> Seventy patients were recruited, (56 females, 14 males). The mean age was 53 years-old [24-74 years-old]. The mean duration of the disease was 10 months [3-24 months]. The RA was active with a median DAS28 5,46 ranging from 2,91 to 7,81. Physical examination highlighted TS in 53 (38%) hands, it was bilateral in 50%. Flexor tendons were the most affected (52 hands). Both flexor and extensor tendons were detected affected in 4 hands. US showed TS in 89 (65%) patients. Flexor tendons showed US activity in 80 hands and extensor tendons in 78 hands. US revealed a significant high frequency of TS over clinical examination (p=0,02). The sensitivity of US to detect TS was 80.3% and the specificity was 50,4%. <h3>Conclusions</h3> The rationale of using US relies on the fact that physical examination provides only limited information on the presence of tenosynovitis. Since TS can be source of functional disagreement, US should be focused, in addition to analyze synovitis, on tendons in RA. <h3>References</h3> Emilio Filippucci, Alessandra Gabba and al. Hand Tendon Involvement in Rheumatoid Arthritis: An Ultrasound Study. Seminars in Arthritis and Rheumatism 2012;41:752-60. Backhaus M, Kamradt T and al. Arthritis of the finger joints: a comprehensive approach comparing conventional radiography, scintigraphy, ultrasound, and contrast-enhanced magnetic resonance imaging. Arthritis Rhem. 1999;42:1232-45. Szkularek M, Court-Payen M and al. Interobserver agreement in ultrasonography of the finger and toe joints in rheumatoid arthritis. Arthritis Rheum.2003;48:955-62. <h3>Disclosure of Interest</h3> None declared
Low Incidence Of Severe Cgvhd and Late NRM In a Phase II Trial Of Thymoglobulin®, Tacrolimus and Sirolimus For Gvhd Prevention
Authors: Zaid Al-Kadhimi, Alireza Eghtedar, Zartash Gul, Wei Chen, Daryn Smith, Abhinav Deol, Muneer H. Abidi, Lawrence G Lum, Divaya Bhutani, Lois Ayash, Voravit Ratanatharathorn, Joseph P. Uberti
Journal: Blood (2013)
Endothelial cell–cardiomyocyte crosstalk in diabetic cardiomyopathy
Authors: Andrea Wan, Brian Rodrigues
Journal: Cardiovascular Research (2016)

The incidence of diabetes is increasing globally, with cardiovascular disease accounting for a substantial number of diabetes-related deaths. Although atherosclerotic vascular disease is a primary reason for this cardiovascular dysfunction, heart failure in patients with diabetes might also be an outcome of an intrinsic heart muscle malfunction, labelled diabetic cardiomyopathy. Changes in cardiomyocyte metabolism, which encompasses a shift to exclusive fatty acid utilization, are considered a leading stimulus for this cardiomyopathy. In addition to cardiomyocytes, endothelial cells (ECs) make up a significant proportion of the heart, with the majority of ATP generation in these cells provided by glucose. In this review, we will discuss the metabolic machinery that drives energy metabolism in the cardiomyocyte and EC, its breakdown following diabetes, and the research direction necessary to assist in devising novel therapeutic strategies to prevent or delay diabetic heart disease.
Quality and Safety in Health Care, Part XIV
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2016)

The work system in which diagnosis takes place is affected by the external environment, which includes requirements such as certification, accreditation, and regulations. How errors are reported, malpractice, and the system for payment are some other aspects of the external environment. Improving the external environment is expected to decrease errors in diagnosis. More research on improving the diagnostic process is needed.
Familial schizophrenia and treatment response
Authors: J M Silverman, R C Mohs, M Davidson, M F Losonczy, R S Keefe, J C Breitner, J E Sorokin, K L Davis
Journal: American Journal of Psychiatry (1987)

Thirty-nine patients with chronic schizophrenia for whom hospitalization was clinically indicated received haloperidol for 4 to 6 weeks in a standardized dose schedule. Responders were compared with nonresponders for family history, baseline symptom factors, and ventricle-brain ratio (VBR). The lifetime risk for schizophrenia spectrum disorders was higher among first-degree relatives of nonresponders than among first-degree relatives of responders. Treatment responders had higher baseline scores on the factors of activation and hostile-suspiciousness, but the groups did not differ in any other baseline symptom factor or in VBR. The authors suggest that there is an association between failure to respond to drugs and genetic loading for schizophrenia spectrum disorders.
AB1169 Making a Case for Signed Written Informed Consent for Rheumatology Patients Started on Disease Modifying Anti-Rheumatic Drugs (DMARDS) in a Rheumatology Clinic:
Authors: R. Basheer, S. Moufarrej, H. Badsha
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Failure on the part of doctors to fully inform their patients of possible side affect of medications is the cause for 10% of all malpractice lawsuits and 40% of Rheumatology lawsuits in United States of America (USA) (1,3). What constitutes a risk is controversial;in one court case a 1% risk of hearing loss required disclosure whereas in another case a 1.5% risk of visual loss did not (2). Currently there is a divide in the United States concerning how physicians are expected to inform their patients. There are two main legal rules up for consideration, the Medical Practice Standard (MPS) (follows the ideology that information should be given at the discretion of physicians) and the Reasonable Person Standard (RPS)(maintains that it is a physician9s duty to give their patients all the information that they might want). <h3>Objectives</h3> To develop a standard format for rheumatologists when discussing the risks of prescription drugs with their patients which would fulfill all legal standards. <h3>Methods</h3> We sent a questionnaire to thirteen rheumatologists who are considered key opinion leaders in the Middle East countries. They were asked "Do you routinely tell your patients in lay terminology about the following side effects of biological drugs?" They were then asked to check all those items that were routinely discussed out of twelve possible side effects that were derived from the American College of Rheumatology patient information leaflet. This questionnaire was also given to twenty patients taking biological drugs asking what side effects they would like to know about. Those items that were selected by at least fifty percent of the doctors were deemed the MPS and by fifty percent of the patients were made the RPS. <h3>Results</h3> See table. <h3>Conclusions</h3> There is a significant discordance between what patients want to know and what their doctors inform them of. To resolve this issue in our practice we have adopted a protocol of informing patients of side effects, giving them a ACR patient information leaflet, and having them sign a consent form. We believe that this will lead to better understanding and compliance from patients and lower risks of litigation. <h3>References</h3> Department of Health Education and Welfare: Report of the Secretary9s Commission on Medical Malpractice (DHEW publication (OS) 73-89) U.S. Government Printing Office: Washington, DC, 1973. Scott v. Wilson, 396 S.W.2d 532 [Tex. Civ. App. 1965] and Yeats v. Hearms, 393 P.2d 982 [Kan. 1964]. Studdert DM, Mello MM, Brennan TA. Medical malpractice. N Engl J Med. 2004;350(3):283-292. <h3>Disclosure of Interest</h3> None declared
Delayed severe extrapyramidal disturbance following frequent depot phenothiazine administration
Authors: A M Warner, S M Wyman
Journal: American Journal of Psychiatry (1975)

The authors report the occurrence of a sever striopallidal disorder in a schizophrenic patient one week after he received fluphenazine enanthate injections on an every-other-day schedule. In view of current interest in depot psychopharmaceuticals, they recommend that careful attention be given to dosage and administration schedules and to the possibility of delayed pseudoparkinsonian symptoms. Emergency room physicians should be alerted to the possible side effects of such drugs.