tbuckley/cabot-search huggingface dataset:
Two New Herpesviruses From Spider Monkeys (&lt;italic&gt;Ateles geoffroyi&lt;/italic&gt;)&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: L. V. Meléndez, H. Castellanos, H.H. Barahona, M. D. Daniel, R. D. Hunt, C. E. O. Fraser, F. G. Garcéa, N. W. King
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Two New Herpesviruses From Spider Monkeys (Ateles geoffroyi) Get access L. V. Meléndez, L. V. Meléndez New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Castellanos, H. Castellanos New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar H.H. Barahona, H.H. Barahona New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar M. D. Daniel, M. D. Daniel New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. D. Hunt, R. D. Hunt New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar C. E. O. Fraser, C. E. O. Fraser New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar F. G. Garcéa, F. G. Garcéa New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar N. W. King N. W. King New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 233–238, https://doi.org/10.1093/jnci/49.1.233 Published: 01 July 1972
Identifying Barriers to Appropriate Use of Metabolic/Bariatric Surgery for Type 2 Diabetes Treatment: Policy Lab Results
Authors: Jennifer K. Rubin, Saba Hinrichs-Krapels, Rachel Hesketh, Adam Martin, William H. Herman, Francesco Rubino
Journal: Diabetes Care (2016)

Despite increasing recognition of the efficacy, safety, and cost-effectiveness of bariatric/metabolic surgery in the treatment of type 2 diabetes, few patients who may be appropriate candidates and may benefit from this type of surgery avail themselves of this treatment option. To identify conceptual and practical barriers to appropriate use of surgical procedures, a Policy Lab was hosted at the 3rd World Congress on Interventional Therapies for Type 2 Diabetes on 29 September 2015. Twenty-six stakeholders participated in the Policy Lab, including academics, clinicians, policy-makers, industry leaders, and patient representatives. Participants were provided with a summary of available evidence about the cost-effectiveness of bariatric/metabolic surgery and the costs of increasing the use of bariatric/metabolic surgery, using U.K. and U.S. scenarios as examples of distinct health care systems. There was widespread agreement among this group of stakeholders that bariatric/metabolic surgery is a legitimate and cost-effective approach to the treatment of type 2 diabetes in obese patients. The following four building blocks were identified to facilitate policy changes: 1) communicating the scale of the costs and harms associated with rising prevalence of type 2 diabetes; 2) properly articulating the role of bariatric/metabolic surgery for certain population groups; 3) identifying new funding sources for bariatric/metabolic surgery; and 4) incorporating bariatric/metabolic surgery into the appropriate clinical pathways. Although more research is needed to identify specific clinical scenarios for the prioritization of bariatric/metabolic surgery, the case appears to be strong enough to engage relevant policy-makers and practitioners in a concerted discussion of how to better use metabolic surgical resources in conjunction with other interventions in good diabetes practice.
Enhanced Lineage‐Specific Differentiation Efficiency of Human Induced Pluripotent Stem Cells by Engineering Colony Dimensionality Using Electrospun Scaffolds
Authors: Maricela Maldonado, Gerardo Ico, Karen Low, Rebeccah J. Luu, Jin Nam
Journal: Advanced Healthcare Materials (2016)

Electrospun scaffolds with varied stiffness promote distinct colony morphology of human induced pluripotent stem cells, which affects their subsequent differentiation. On soft scaffolds, induced pluripotent stem cells develop 3D colonies due to the pliability of the electrospun fibrous networks, leading to greater differentiation tendency to ectodermal lineage.
Ticagrelor versus Clopidogrel in Acute Coronary Syndromes
Authors: Robert S Rosenstein, David Parra
Journal: New England Journal of Medicine (2009)

To the Editor: In the Study of Platelet Inhibition and Patient Outcomes (PLATO), Wallentin et al. (Sept. 10 issue) 1 found that in patients with acute coronary syndromes, the use of ticagrelor, as compared with clopidogrel, significantly reduced the rate of death, myocardial infarction, or stroke without increasing the rate of bleeding. Ticagrelor, a direct-acting oral antagonist of the adenosine diphosphate receptor, was associated with adverse events, including dyspnea, ventricular pauses, and increased levels of creatinine and uric acid. Although the mechanism of these effects is unknown, components of the molecular structure of ticagrelor are almost identical to those of adenosine, which can be degraded to uric acid, and it is conceivable that metabolites of ticagrelor activate adenosine receptors. It is well known that adenosine induces dyspnea by broncho
Abstract P5-17-04: Breast conserving surgery alone for ductal carcinoma in situ: Factors associated with increased risk of local recurrence
Authors: A Recht, A Mele, P Mehta, A Brook, P Slanetz, R Sharma
Journal: Cancer Research (2016)

Abstract Background: There is ongoing debate regarding the added benefit of radiation therapy (RT) for patients with ductal carcinoma in situ (DCIS) believed to be at low risk for recurrence after wide local excision (WLE) alone since RT is costly and can cause significant adverse effects. In this retrospective study we aimed to identify clinicopathological characteristics associated with an increased risk for ipsilateral local recurrence (LR) in patients not undergoing RT. Methods: All patients with DCIS treated with WLE alone at the Beth Israel Deaconess Medical Center, Boston between 2000 and 2010 were identified. We collected data on demographics, parity, personal or family history of breast cancer, exogenous hormone use, tobacco use, comorbidities, genetic mutation carrier status, imaging interval, and tumor-specific characteristics (size, margins, grade, architectural subtype, presence of necrosis, estrogen receptor status). We analyzed their effects on the risk of LR. Results: The study cohort included 281 eligible patients (mean age at diagnosis 59 years, range 33-90). Median follow-up time was 8 years (range 0.11-16.59 years); 59 patients were excluded because they were not followed in our institution after undergoing WLE. LR occurred in 19 of 222 patients (9%), with a recurrence rate of 11.3 per 1000 person-years. The median time from excision to LR was 4.2 years (range, 0.8-11.7). The risk of recurrence was lower for the 64 patients with nuclear grade (NG) I tumors than for the 110 patients with a NG II or 20 patients NG III tumors (3%, 9%, and 20%, respectively, p for trend = 0.01). The mean margin width was 1.8 mm in patients experiencing LR, versus 2.5 mm in patients without LR (p=0.4). Patients who had used hormone replacement therapy or oral contraceptives (n=61) or patients with a history of tobacco use (n=41) had higher rates of LR than those who did not, although these did not reach statistical significance (15% versus 6%, p=0.06; and 17% versus 7%, p=0.07 respectively). There was no significant correlation between the use of tamoxifen or aromatase inhibitors and the risk of LR. Conclusions: Our data indicate that higher nuclear grade, narrower margin width, use of exogenous hormones, and smoking history may be associated with an increased risk of LR. The evaluation of these factors may be helpful when considering whether to use adjuvant RT or not for patients with DCIS. Citation Format: Recht A, Mele A, Mehta P, Brook A, Slanetz P, Sharma R. Breast conserving surgery alone for ductal carcinoma in situ: Factors associated with increased risk of local recurrence. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-17-04.
Objective personality changes in residents of a therapeutic community
Authors: J G Sacks, N M Levy
Journal: American Journal of Psychiatry (1979)

The authors tested several groups of drug-abusing young adults who were residents of a drug-free therapeutic community. Three instruments were used: staff ratings, sociometric ratings by members of the community, and MMPI scores. All three measures showed objective evidence of decreasing psychopathology correlated with length of time in treatment, demonstrating the effectiveness of the therapeutic community in the rehabilitation of drug abusers. Individuals who left before completing treatment had MMPI scores indicating inability to develop social relationships; this elucidates a probable cause of the dropout phenomenon.
A Maturing Use of Defibrillators
Authors: Joanne Lynn
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Phase 3 study of anti-CCR4 monoclonal antibody mogamulizumab versus vorinostat in relapsed or refractory cutaneous T-cell lymphoma (CTCL).
Authors: Youn H. Kim, Martine Bagot, Herbert Aaron Eradat, Kenneth Robert Carson, John P. Greer, Ellen J. Kim, Timothy Kuzel, Lauren C Hughey, Brian Poligone, Frederick Lansigan, Pier Luigi Zinzani, Lisa M Grandinetti, Pierluigi Porcu, Andrei R. Shustov, Neil J Korman, Ahmad Halwani, Lubomir Sokol, Madeleine Duvic
Journal: Journal of Clinical Oncology (2014)

TPS8623 Background: CC chemokine receptor 4 (CCR4) is selectively expressed on type 2 helper T cells and certain functional regulatory T cells. Its expression allows T-cell trafficking to skin and lymph nodes. CCR4 is also expressed on CTCL cells. Expression increases with advancing disease stage and is closely associated with an unfavorable disease outcome. Advanced CTCL is a clinically unmet need due to short survivals and absence of curative treatments. Mogamulizumab (KW-0761) is a humanized anti-CCR4 monoclonal antibody with a defucosylated Fc region that enhances antibody-dependent cell-mediated cytotoxicity (ADCC). In an in vitro ADCC assay and a humanized mouse in vivo model, mogamulizumab exhibited potent antitumor activity against T-cell lymphoma cell lines as well as against primary CTCL cells from patients. Preliminary clinical data suggest mogamulizumab may lead to responses in CTCL, even in CCR4 negative disease by immunohistochemistry. Methods: This is a first-in-kind Phase 3 trial that compares mogamulizumab to a standard of care in patients with relapsed/refractory CTCL afterat least 1 prior systemic therapy, regardless of CCR4 expression. Inclusion criteria include: ECOG performance score < 1; adequate hematological, hepatic, and renal function. Patients are stratified by disease type (Sézary syndrome vs mycosis fungoides) and stage, and are randomized (1:1) to receive mogamulizumab or vorinostat. Patients who are unable to tolerate or progress on vorinostat may cross over to mogamulizumab. Response assessments are done by the modified skin weighted assessment tool and global composite response including skin, blood, lymph node and viscera assessments. The study’s primary endpoint is progression free survival (PFS). The PFS of the experimental and comparator arms will be compared using a stratified log-rank test at the one-sided 2.5% significance level. The median PFS for mogamulizumab therapy is targeted for 254 days, a 50% improvement over the reference median PFS for vorinostat of 169 days. A total of 255 PFS events will give 90% power. Clinical trial information: NCT01728805.
Duration of ECT-induced tachycardia as a measure of seizure length
Authors: G Larson, C Swartz, R Abrams
Journal: American Journal of Psychiatry (1984)

The duration of ECT-induced tachycardia in 203 seizures of 28 patients was measured. Tachycardia duration was easily determined; it correlated highly with both motor (cuffed arm) and EEG seizure estimates.
Effects of childhood relationships on the adult's capacity to form social supports
Authors: J A Flaherty, J A Richman
Journal: American Journal of Psychiatry (1986)

Social supports have been viewed as central to psychological well-being, but little attention has been directed to the capacity to form supportive relationships. Psychoanalytic perspectives suggest that the quality of adult relationships is derived from earlier childhood attachment experiences. The authors tested this thesis by correlating medical students' perceptions of their earlier relationships with their parents with the perceived quality of their current social support networks. The data suggest the need for a more complex and psychodynamically relevant conceptualization of social supports, which has implications for therapeutic interventions to ameliorate support deficits.
Adipocyte Exosomes Promote Melanoma Aggressiveness through Fatty Acid Oxidation: A Novel Mechanism Linking Obesity and Cancer
Authors: Ikrame Lazar, Emily Clement, Stéphanie Dauvillier, Delphine Milhas, Manuelle Ducoux-Petit, Sophie LeGonidec, Cédric Moro, Vanessa Soldan, Stéphane Dalle, Stéphanie Balor, Muriel Golzio, Odile Burlet-Schiltz, Philippe Valet, Catherine Muller, Laurence Nieto
Journal: Cancer Research (2016)

Abstract Malignant progression results from a dynamic cross-talk between stromal and cancer cells. Recent evidence suggests that this cross-talk is mediated to a significant extent by exosomes, nanovesicles secreted by most cell types and which allow the transfer of proteins, lipids, and nucleic acids between cells. Adipocytes are a major component of several tumor microenvironments, including that of invasive melanoma, where cells have migrated to the adipocyte-rich hypodermic layer of the skin. We show that adipocytes secrete exosomes in abundance, which are then taken up by tumor cells, leading to increased migration and invasion. Using mass spectrometry, we analyzed the proteome of adipocyte exosomes. Interestingly, these vesicles carry proteins implicated in fatty acid oxidation (FAO), a feature highly specific to adipocyte exosomes. We further show that, in the presence of adipocyte exosomes, FAO is increased in melanoma cells. Inhibition of this metabolic pathway completely abrogates the exosome-mediated increase in migration. Moreover, in obese mice and humans, both the number of exosomes secreted by adipocytes as well as their effect on FAO-dependent cell migration are amplified. These observations might in part explain why obese melanoma patients have a poorer prognosis than their nonobese counterparts. Cancer Res; 76(14); 4051–7. ©2016 AACR.
New Mutation in ALAS2 as the Cause of X-Linked Sideroblastic Anemia Responsive to Pyridoxine: Comparison of ALAS2-Defective and DMT1-Defective BFU-E Growth.
Authors: Jana Kucerova, Monika Horvathova, Petra Belohlavkova, Jaroslav Cermak, Vladimir Divoky
Journal: Blood (2009)
Endoscopic resection and colonic stoma: endoscopic submucosal dissection at the hepatic flexure using an upper gastrointestinal scope and endoscopic mucosal resection by hand at the everted edge of the stoma
Authors: Laure Servais, Jérome Rivory, Isabelle Lienhart, Gaspard Bertrand, Camille Giacino, Thierry Ponchon, Mathieu Pioche
Journal: Endoscopy (2016)

A 71-year-old man with a 6-cm, nongranular, laterally spreading tumor (NG-LST) at the hepatic flexure was referred to our unit for endoscopic submucosal dissection (ESD) because of a central depression in the lesion. He had previously undergone Hartmann's surgery [1] for a sigmoid adenocarcinoma (pT3N0M0) in April 2015. Surgeons preferred to maintain the stoma because of co-morbidities (amputation of both legs, diabetes, stroke). Thus, ESD was performed at the hepatic flexure via the stoma.
Diagnosis of local relapse after radical radiotherapy (RRTH) of prostate cancer by biochemical PSA kinetics and transrectal ultrasonography (TRUS) verified by prostate biopsy
Authors: K. E. Nietupski, T. Demkow, I. Skoneczna, M. Pilichowska, P. Peczkowski, E. Kraszewska, M. Ligaj, G. Poniatowska, A. Sieczych, A. Chaladaj-Kujawska, B. Sikora
Journal: Journal of Clinical Oncology (2006)

14631 Background: Patients (pts) with the cancer of the prostate after radical radiotherapy (RRTH) are followed by clinical examination, periodical measurements of PSA level, bone scan, bone x-ray examinations, CT of abdomen and pelvis. The biochemical progression (according ASTRO Consensus Panel) is not always equal the clinical progression. The next step in all cases of rising PSA is to diagnose or to exclude the local progression, which has to be distinguished from systemic progression. Methods: Prospective evaluation of effectiveness of the biochemical indicators as predictors of local relapse after RRTH and probability of positive tru-cut biopsy outcome in case of positive TRUS result. 51 pts with prostatic adenocarcinoma after RRTH, who experienced biochemical (PSA) progression were included. All of them had a negative bone scan results, negative abdomen-pelvis CT scan or ultrasonography and no clinical evidence of distant metastases. All pts underwent a tru-cut biopsy guided by TRUS. Each of them were eligible to local salvage procedures. The TRUS-guided tru-cut biopsy were performed in all pts. Results: The median observation time (between RRTH and biopsy) was 34 mo (11–78). The median PSA level at the biopsy was 2.46 ng/ml (0,69–11,26). TRUS was positive in 20/51 pts. In 31 pts, there was no evidence of local progression in TRUS. TRUS specificity was 62.02% (95% CI 48.75–75.39%) and sensitivity 40.91% (95% CI 27.42%–54.40). The biopsy outcome was positive in 22/51 pts (43%). The biopsy was positive in 58% (25/26) in subgroup with PSA level lower than 2.46 ng/ml and 27% (7/25) in group with PSA upper to this value. There were no significant associations between positive biopsy outcome and PSA velocity. Conclusions: In pts with suspicion of local relapse we observed the low predictive value of PSA level at biopsy (area under ROC curve = 0.6113). There were no associations between positive biopsy outcome and PSADT (PSA doubling time) which could help in better selection for invasive procedure. No significant financial relationships to disclose.
Authors’ reply to Patel and colleagues
Authors: Xin Sun, Gordon H Guyatt, Ling Li
Journal: BMJ (2016)

We appreciate Patel and colleagues’ comments about our systematic review and meta-analysis of the effects of dipeptidyl peptidase-4 (DPP-4) inhibitors on heart failure and hospital admission for heart failure.1 2 We concluded that the relative effect on heart failure was uncertain, given the limitations of current evidence …
The Clinician's Responsibility for Helping to Improve the Treatment of Tomorrow's Patients
Authors: Bucknam McPeek, John P. Gilbert, Frederick Mosteller
Journal: New England Journal of Medicine (1980)

In addition to using his or her knowledge and skills for treating today's patient, the clinician has a responsibility to strengthen medical knowledge and upgrade the quality of care that will be available in the future. The ways in which clinicians can make such a contribution include devising clinically relevant descriptive scales, avoiding pitfalls, advising patients eligible to participate in trials, and supporting efforts to improve the testing of new therapies.The physician knows that applying a therapeutic procedure in practice is vastly different from testing it in the carefully regulated conditions of the laboratory. The controlled trial provides a . . .
Visible physical impairment and psychological adjustment among pediatric cancer survivors
Authors: J E O'Malley, D Foster, G Koocher, L Slavin
Journal: American Journal of Psychiatry (1980)

Because psychological and psychiatric assessments of childhood cancer survivors have revealed a high rate of psychiatric sequelae, the authors investigated the relationship between the degree of physical unpairment resulting from cancer treatment and the psychosocial adjustment problems of survivors. Ratings of physical impairment were based on the visibility of physical residua as well as the functional limitations they imposed. The results indicated that the psychosocial adjustment of survivors is not significantly related to the severity of physical impairment.