tbuckley/cabot-search huggingface dataset:
The effect on pCR of bevacizumab and/or antimetabolites added to standard neoadjuvant chemotherapy: NSABP protocol B-40.
Authors: H. D. Bear, G. Tang, P. Rastogi, C. E. Geyer, A. Robidoux, J. N. Atkins, L. Baez, A. Brufsky, R. S. Mehta, L. Fehrenbacher, E. R. Pajon, F. M. Senecal, R. Gaur, R. G. Margolese, P. T. Adams, H. M. Gross, S. M. Swain, E. P. Mamounas, J. P. Costantino, N. Wolmark
Journal: Journal of Clinical Oncology (2011)

LBA1005 Background: The addition of capecitabine (X), gemcitabine (G), and bevacizumab (B) to taxanes have each improved PFS in metastatic breast cancer. The primary aims of this trial were to determine if adding X or G to docetaxel (T) → AC will increase breast pathologic complete response (pCR) rates in operable, HER2-negative breast cancer and if adding B to T-based regimens →AC will increase pCR rates. Secondary aims included assessment of clinical complete response (cCR) rates. Methods: Pts received one of 3 T-based regimens, with or without B, 15mg/kg, q3wks x 4: T 100 mg/m 2 day 1; T 75 mg/m 2 day 1 and X 825 mg/m 2 BID days 1-14; or T 75 mg/m 2 day 1 and G 1000 mg/m 2 days 1 and 8. Pts then received preoperative AC x 4, with or without B for the initial 2 cycles of AC. Pts randomized to B resumed B for 10 postop doses. The primary endpoint was pCR in the breast. The maximum of the standardized pairwise differences between pCR rate for the T → AC regimen and for the other 2 T-based regimens was used as the test statistic to adjust for multiple comparisons. Fisher’s exact test was used to compare the arms with and without B. Results: The groups were balanced, with 47% clinically node+, 56% poorly differentiated, and 59% HR+. Assessments for pCR were available from 1180 of 1206 randomized patients. pCR for TX and TG were 29.7% and 32% vs. 32.7% for T. Neither TX nor TG increased cCR rates relative to T (58.3% and 60.4% vs. 61.5%). TX and TG increased toxicity. Addition of B increased the pCR rate (28.4 vs. 34.5%, p=0.027) and the cCR rate (55.8 vs. 64.3%, p=0.007). The effect of B was predominantly in the HR+ subset (15.2 vs. 23.3%, p=0.008) with minimal effect in the HR- subset (47.3% vs. 51.3%, p=0.44). Grades 2/3/4 toxicities increased with B were HTN (1/&lt;1/0% vs. 13/9/&lt;1%), HFS (11/7/0% vs. 15/11/0%), and mucositis (10/3/0% vs. 20/5/0%). Conclusions: The addition of B to neoadjuvant chemotherapy improved pCR and cCR rates, but the addition of X or G to T did not improve outcomes. Follow-up for wound healing issues and DFS will help define the role of B in the treatment of early breast cancer. Funded by NCI PHS grants U10-CA-37377, U10-CA-69974, U10-CA-12027, U10-CA-69651, and U10-CA-44066, and F. Hoffmann La-Roche, Ltd., Genentech, USA, and Eli Lilly.
Developing respiratory services – What are the needs of the respiratory clinician leaders and what can a short course deliver?
Authors: Steve Holmes, Nicky Bullen, Stephen Gaduzo, Basil Penney, Sandy Walmsley
Journal: European Respiratory Journal (2011)

Background: The development of services within health care systems is complex and requires expertise in clinical, economic and managerial issues. Within the UK, clinicians are being expected to work with managers and commissioners to develop services. This newly recognised area of work requires personal development. An ongoing programme of learning was developed to support respiratory leaders in this increasingly challenging role.

Method: The PCRS-UK have developed bi-annual courses to support clinical respiratory leaders in understanding the many issues that are required to enable the leader to influence service development and to support their own teams in changing services in line with best medical evidence. The course evaluations have provided useful information on areas that clinicians wish to develop as they move into leadership roles and demonstrate the potential development from attending a short course.

Results: 64 participants completed the most recent course. Around 2/3 of delegates provided feedback on their skills/confidence. This demonstrated widespread requirements in both understanding NHS policy and direction as well as core leadership skills (understanding others, developing groups, organising and chairing meetings, communicating with commissioners). The course achieved considerable improvements in confidence and skills in most of these areas.

Conclusions: There is a clear need to support the clinical respiratory leaders of the future who have considerable developmental needs to complement their clinical expertise. The areas for this can be identified and a relatively short and focused course can make a significant impact on these needs.
Recorded and Expected Mortality among the Indians of the United States with Special Reference to Cancer
Authors: Robert Lincoln Smith, M.D.
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Recorded and Expected Mortality among the Indians of the United States with Special Reference to Cancer Get access Robert Lincoln Smith, M.D. Robert Lincoln Smith, M.D. Field Investigations and Demonstrations Branch, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 3, March 1957, Pages 385–396, https://doi.org/10.1093/jnci/18.3.385 Published: 01 March 1957
Effect of Mediterranean Diet on the prevalence of breast cancer relapse: preliminary results of the “SETA PROJECT”
Authors: C. Biasini, C. Di Nunzio, M.R. Cordani, M. Ambroggi, M. Fontana, F.M. Cicognini, C. Razza, A. Pazzoni, C. Perri, F. Rossi, E. Trevisi, M. Confalonieri, M. Negrati, L. Cavanna
Journal: Annals of Oncology (2015)
On the safety of long-term treatment with lithium
Authors: M J Friedman, C M Culver, R B Ferrell
Journal: American Journal of Psychiatry (1977)

Thirteen patients with bipolar affective illness who had received lithium therapy for 1-5 years were tested retrospectively for evidence of cortical dysfunction. Data on patients younger than 55 show no abnormalities on the Halstead-Reitan Neuropsychological Battery and suggest that chronic lithium therapy is relatively safe. Significantly elevated Halstead Impairment indexes were observed among elderly patients, but these data are difficult to interpret.
Student mental health services and departments of psychiatry
Authors: C B Reifler, R Babineau
Journal: American Journal of Psychiatry (1976)

The authors suggest that the potential usefulness of a college mental health service as a site for teaching, training, and research has been understimated by departments of psychiatry. College health services can provide an opportunity for both trainees and investigators to deal with concepts of psychotherapeutic intervention, a developmental perspective, and a community mental health orientation.
MB-83OMEGA-3 FATTY ACIDS DHA AND EPA SUPPRESS ONCOGENIC PGE2 IN MEDULLOBLASTOMA
Authors: Linda Ljungblad, Filip Bergqvist, Teodora Andonova, Per-Johan Jakobsson, John Inge Johnsen, Helena Gleissman, Per Kogner, Malin Wickström
Journal: Neuro-Oncology (2016)
Case 18-1967
Authors: Marian W. Ropes, G. Richard Dickersin
Journal: New England Journal of Medicine (1967)

Presentation of Case First admission. A sixty-one-year-old man was admitted to the hospital because of weakness and dyspnea.He had been well until two years previously, when he noticed the gradual onset of stiffness of the shoulders and knees and weakness of the hands, arms and legs. A few months before entry he became unable to grip or lift objects. For an indefinite period he had experienced dyspnea on exertion and fatigue at the end of the day. One week before admission he was forced to stop working.As a young man he had worked in a shipyard in . . .
Abstract 19771: Persistent Thrombocytopenia after Myocardial Infarction is Associated with Increased Short- and Long-Term Mortality
Authors: Anirudh Kumar, Salim Virani, Scott Bassett, Mahboob Alam, Ravi Hira, Andrew Caruso, David Paniagua, Ali Denktas, Ihab Hamzeh, Glenn Levine, Christie Ballantyne, Anita Deswal, Biykem Bozkurt, Hani Jneid
Journal: Circulation (2014)

Background: Thrombocytopenia (TCP) occurs commonly in patients hospitalized with acute myocardial infarction (AMI). It is unclear whether persistent TCP after discharge among AMI survivors is associated with worse outcomes. Methods: We examined the impact of persistent post-discharge TCP on outcomes in a registry of consecutive AMI patients hospitalized between January 2004 and December 2007. In-hospital (IH) TCP was defined by a nadir platelet count &lt; 150 x 109/L. Resolved TCP was defined as IH TCP which resolved within 3 months after discharge while persistent TCP was defined as IH TCP which did not resolve within 3 months. Results: Of 842 patients hospitalized for a first AMI, we examined data on 617 hospital survivors who had follow-up within 3 months of discharge and documented long-term outcomes. Of those, 474 (76.8%) patients did not experience IH TCP while 42 (6.8%) and 101 (16.4%) had persistent and resolved TCP, respectively (Table). Patients with persistent TCP were older, had worse comorbidities, and were more likely to have TCP at baseline and discharge. There were no inter-group differences in infarct size, major bleeding complications, revascularization, or ejection fraction at discharge. Mortality following discharge was higher at all time-points among AMI patients with persistent TCP compared to patients with resolved or without IH TCP (Figure). Patients with resolved TCP had comparable mortality to those without IH TCP. Conclusion: Persistent TCP within 3 months after hospital discharge for AMI is associated with significantly increased short- and long-term mortality compared to patients with recovered TCP or without IH TCP.
EPT-23TREATMENT OF HIGH-GRADE CENTRAL NERVOUS SYSTEM TUMORS WITH HIGH-DOSE METHOTREXATE IN COMBINATION WITH MULTI-AGENT CHEMOTHERAPY: A SINGLE INSTITUTION EXPERIENCE
Authors: Elizabeth Alva, Gregory Friedman, Rong Li, Curtis Rozzelle, Brandon Rocque, Jeffery Blount, James Johnston, John Fiveash, Alyssa Reddy
Journal: Neuro-Oncology (2016)
Digitalis Bigeminy
Authors: Elliot L. Sagall, Louis Wolff
Journal: New England Journal of Medicine (1949)

BIGEMINAL rhythm following the administration of digitalis is frequently encountered and is generally accepted as a sign of digitalis intoxication. The characteristics of this type of coupled rhythm, however, are not clearly defined, and there is little in the literature concerning the subject. The present investigation was undertaken in an attempt to elucidate the features of digitalis bigeminy that might be of practical clinical value.MethodsThe patients studied were limited to those in whom paroxysmal or constant ventricular bigeminy was demonstrated electrocardiographically. Of the electrocardiograms taken from 1929 to 1948 at the Beth Israel Hospital, Boston, 183 separate cases . . .
“Red Cell Complement Loading In PNH Patients On Eculizumab Is Associated With a C3 Polymorphism Which Influences C3 Function, Predicts For Increased Extravascular Hemolysis and Provides a Rationale For C3 Inhibition.”
Authors: Praveen Kaudlay, Haiying Hua, Guansheng He, Darren J Newton, Abraham M Varghese, Talha Munir, Anita Hill, Richard J Kelly, Stephen John Richards, Peter Hillmen
Journal: Blood (2013)
Changing Patterns of Graduate Medical Education
Authors: Donald M. Steinwachs, David M. Levine, D. Jack Elzinga, David S. Salkever, Rodger D. Parker, Carol S. Weisman
Journal: New England Journal of Medicine (1982)

Abstract Postgraduate medical education underwent substantial change during the 1970s: medical-school classes grew, the internship year was eliminated, and the numbers of M.D.s entering primary-care specialties increased. The purpose of this study is to develop a planning model of graduate medical education that can project the impact of these and other changes on the numbers and specialty mix of physicians completing training. The model is applied to an analysis of trends in graduate medical education and to the probable consequences of policy recommendations made by the Graduate Medical Education National Advisory Committee (GMENAC). The results show that the trend toward increasing percentages of M.D.s entering primary-care specialties from 1970 to 1976 changed to no increase from 1976 to 1980. Thus, the GMENAC policy recommendation to increase primary care further is not likely to occur spontaneously in the near future. (N Engl J Med. 1982; 306:10–4.)
Subcutaneous Fibrosarcomas in Strains C3H and C57BL Female Mice, and F&lt;sub&gt;1&lt;/sub&gt; and Backcross Hybrids of these Strains
Authors: Thelma B. Dunn, Walter E. Heston, Margaret K. Deringer
Journal: JNCI Journal of the National Cancer Institute (1956)

Subcutaneous Fibrosarcomas in Strains C3H and C57BL Female Mice, and F1 and Backcross Hybrids of these Strains Get access Thelma B. Dunn, Thelma B. Dunn National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Walter E. Heston, Walter E. Heston National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer Margaret K. Deringer National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages 639–655, https://doi.org/10.1093/jnci/17.5.639 Published: 01 November 1956 Article history Received: 13 July 1956 Published: 01 November 1956
Technique for the Induction of Metastasizing and Transplantable Fibrosarcomas With Croton Oil<xref ref-type="fn" rid="fn1">2</xref>
Authors: Hans Selye
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Technique for the Induction of Metastasizing and Transplantable Fibrosarcomas With Croton Oil Get access Hans Selye Hans Selye Institut de Médecine et de Chirurgie expérimentales, Université de Montréal, Montreal, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 5, April 1955, Pages 1291–1305, https://doi.org/10.1093/jnci/15.5.1291 Published: 01 April 1955 Article history Received: 23 August 1954 Published: 01 April 1955
MB-46PROGNOSTIC RELEVANCE OF EPIGENETIC/BIOLOGICAL SUBGROUPS AND MYCC/MYCN GENE AMPLIFICATION IN A HOMOGENOUSLY TREATED METASTATIC MEDULLOBLASTOMA HIT2000 COHORT AGED 4-21 YEARS
Authors: André O. von Bueren, David T. Jones, Tobias Goschzik, Rolf-Dieter Kortmann, Katja von Hoff, Carsten Friedrich, Martin Mynarek, Anja zur Mühlen, Nicolas Gerber, Monika Warmuth-Metz, Frank Deinlein, Martin Benesch, Robert Kwiecien, Andreas Faldum, Volker Hovestadt, Paul A. Northcott, Joachim Kuehl, Marcel Kool, Stefan Pfister, Torsten Pietsch, Stefan Rutkowski
Journal: Neuro-Oncology (2016)
Robotic double-loop reconstruction method following total gastrectomy
Authors: Amilcare Parisi, Stefano Trastulli, Francesco Ricci, Roberto Cirocchi, Daniele Pironi, Alberto Santoro, Jacopo Desiderio
Journal: Endoscopy (2016)

Minimally invasive surgery for gastric cancer is a challenge. The reconstructive time is a particular issue and researchers have adopted a large variety of solutions and produced heterogeneous data.
Inducing enhanced immunogenic cell death with nanocarrier-based drug delivery systems for pancreatic cancer therapy
Authors: Xiao Zhao, Keni Yang, Ruifang Zhao, Tianjiao Ji, Xiuchao Wang, Xiao Yang, Yinlong Zhang, Keman Cheng, Shaoli Liu, Jihui Hao, He Ren, Kam W. Leong, Guangjun Nie
Journal: Biomaterials (2016)
Seven day GP service reduces hospital emergency visits, study finds
Authors: Susan Mayor
Journal: BMJ (2016)

Opening general practices seven days a week reduced the number of visits to hospital accident and emergency departments by nearly 18% at weekends, an evaluation of a pilot scheme in London has estimated.1

Researchers analysed patient level data from four general practices in central London that started piloting seven day opening at various times from April 2013, paid for by the Prime Minister’s Challenge Fund. They compared emergency department visits as shown in secondary uses service data among patients at the pilot practices with patients from 30 practices in central London that didn’t offer appointments across seven days.

Results showed that, before …
Molecular Lesions Of Signalling Pathway Genes In Indolent B-Cell Lymphoproliferations Mimicking Splenic Marginal Zone Lymphoma
Authors: Davide Rossi, Alessio Bruscaggin, Sara Monti, Stefania Cresta, Rosella Famà, Luca Arcaini, Silvia Franceschetti, Marco Lucioni, Fabrizio Tabbò, Enrico Tiacci, Giorgio Inghirami, Marco Paulli, Brunangelo Falini, Robin Foà, Gianluca Gaidano
Journal: Blood (2013)
Dermoscopic findings of vulvar intraepithelial neoplasia: a series of four cases
Authors: A. Barisani, E. Dika, P.A. Fanti, P. De Iaco, G. Tosti, A. Patrizi, S. Vaccari
Journal: British Journal of Dermatology (2016)

Vulvar intraepithelial neoplasia (VIN) is a subtype of in situ squamous cell carcinoma (SCC). The diagnosis is clinical and histopathological. Dermoscopy of VIN has been scarcely reported. Herein we describe the dermoscopic features in 4 female patients.

This article is protected by copyright. All rights reserved.
Efficacy of N-Formyl-Sarcolysine in Treatment of Some Malignant Diseases: Preliminary Clinical Report
Authors: W HUAN-HSING, C CHI-CH'ANG, S YEN, F HUEI-YING
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Next generation sequencing technology and genomewide data analysis: Perspectives for retinal research
Authors: Vijender Chaitankar, Gökhan Karakülah, Rinki Ratnapriya, Felipe O. Giuste, Matthew J. Brooks, Anand Swaroop
Journal: Progress in Retinal and Eye Research (2016)

The advent of high throughput next generation sequencing (NGS) has accelerated the pace of discovery of disease-associated genetic variants and genomewide profiling of expressed sequences and epigenetic marks, thereby permitting systems-based analyses of ocular development and disease. Rapid evolution of NGS and associated methodologies presents significant challenges in acquisition, management, and analysis of large data sets and for extracting biologically or clinically relevant information. Here we illustrate the basic design of commonly used NGS-based methods, specifically whole exome sequencing, transcriptome, and epigenome profiling, and provide recommendations for data analyses. We briefly discuss systems biology approaches for integrating multiple data sets to elucidate gene regulatory or disease networks. While we provide examples from the retina, the NGS guidelines reviewed here are applicable to other tissues/cell types as well.
Foundation trusts
Authors: J. Dixon
Journal: BMJ (2003)

Much heat and light have been generated in the media recently as a result of the second reading in the House of Commons of the Health and Social Care Act 2003. The most controversial aspect of the bill was the proposal to allow NHS trusts to become NHS foundation trusts, with extra freedoms to run their affairs compared with other NHS trusts.1 Three main freedoms have been granted. Firstly, foundations can borrow capital, sell assets, and importantly retain in-year surpluses. Secondly, direct control from the Department of Health will be relaxed and greater managerial freedoms granted—for example, to reward staff—and foundation trusts will be accountable to a new independent regulator. Thirdly, more freedoms will exist with respect to how foundation trusts are governed, although they will have to establish a new board of governors elected in part by local communities.
Association Between Maternal Prepregnancy Body Mass Index and Plasma Folate Concentrations With Child Metabolic Health
Authors: Guoying Wang, Frank B. Hu, Kamila B. Mistry, Cuilin Zhang, Fazheng Ren, Yong Huo, David Paige, Tami Bartell, Xiumei Hong, Deanna Caruso, Zhicheng Ji, Zhu Chen, Yuelong Ji, Colleen Pearson, Hongkai Ji, Barry Zuckerman, Tina L. Cheng, Xiaobin Wang
Journal: JAMA Pediatrics (2016)

<h3>Importance</h3> Previous reports have linked maternal prepregnancy obesity with low folate concentrations and child overweight or obesity (OWO) in separate studies. To our knowledge, the role of maternal folate concentrations, alone or in combination with maternal OWO, in child metabolic health has not been examined in a prospective birth cohort. <h3>Objective</h3> To test the hypotheses that maternal folate concentrations can significantly affect child metabolic health and that sufficient maternal folate concentrations can mitigate prepregnancy obesity-induced child metabolic risk. <h3>Design, Setting, and Participants</h3> This prospective birth cohort study was conducted at the Boston Medical Center, Boston, Massachusetts. It included 1517 mother-child dyads recruited at birth from 1998 to 2012 and followed up prospectively up to 9 years from 2003 to 2014. <h3>Main Outcomes and Measures</h3> Child body mass index<i>z</i>score calculated according to US reference data, OWO defined as a body mass index in the 85th percentile or greater for age and sex, and metabolic biomarkers (leptin, insulin, and adiponectin). <h3>Results</h3> The mean (SD) age was 28.6 (6.5) years for mothers and 6.2 (2.4) years for the children. An L-shaped association between maternal folate concentrations and child OWO was observed: the risk for OWO was higher among those in the lowest quartile (Q1) as compared with those in Q2 through Q4, with an odds ratio of 1.45 (95% CI, 1.13-1.87). The highest risk for child OWO was found among children of obese mothers with low folate concentrations (odds ratio, 3.05; 95% CI, 1.91-4.86) compared with children of normal-weight mothers with folate concentrations in Q2 through Q4 after accounting for multiple covariables. Among children of obese mothers, their risk for OWO was associated with a 43% reduction (odds ratio, 0.57; 95% CI, 0.34-0.95) if their mothers had folate concentrations in Q2 through Q4 compared with Q1. Similar patterns were observed for child metabolic biomarkers. <h3>Conclusions and Relevance</h3> In this urban low-income prospective birth cohort, we demonstrated an L-shaped association between maternal plasma folate concentrations and child OWO and the benefit of sufficient folate concentrations, especially among obese mothers. The threshold concentration identified in this study exceeded the clinical definition of folate deficiency, which was primarily based on the hematological effect of folate. Our findings underscore the need to establish optimal rather than minimal folate concentrations for preventing adverse metabolic outcomes in the offspring.