tbuckley/cabot-search huggingface dataset:
P803 PHARMACOLOGICAL INHIBITION OF THE CHEMOKINE CXCL16 DIMINISHES LIVER MACROPHAGE INFILTRATION AND STEATOHEPATITIS IN CHRONIC HEPATIC INJURY
Authors: A. Wehr, C. Baeck, N. Gassler, K. Hiththetiya, C. Trautwein, F. Tacke
Journal: Journal of Hepatology (2014)
Abstract 3985: Senescent cells in growing tumors: population dynamics and cancer stem cells
Authors: Caterina Anna Maria LaPorta, Stefano Zapperi, James Sethna
Journal: Cancer Research (2012)

Abstract Tumors are defined by their intense proliferation, but sometimes cancer cells turn senescent and stop replicating. In the stochastic cancer model in which all cells are tumorigenic, senescence is seen as the result of random mutatations, suggesting that it could represent a barrier to tumor growth. In the hierarchical cancer model a subset of the cells, the cancer stem cells, divide indefinitely while other cells eventually turn senescent. Here we formulate cancer growth in mathematical terms and obtain predictions for the evolution of senescence. We perform experiments in human melanoma cells which are compatible with the hierarchical model and show that senescence is a reversible process controlled by survivin. We conclude that enhancing senescence is unlikely to provide a useful therapeutic strategy to fight cancer, unless the cancer stem cells are specifically targeted. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3985. doi:1538-7445.AM2012-3985
PHYSICAL ACTIVITY AND MAJOR ADVERSE EVENTS IN PATIENTS WITH ATRIAL FIBRILLATION: A REPORT FROM THE EUROBSERVATIONAL RESEARCH PROGRAMME PILOT SURVEY ON ATRIAL FIBRILLATION (EORP-AF) GENERAL REGISTRY
Authors: Marco Proietti, Giuseppe Boriani, Cécile Laroche, Igor Diemberger, Mircea I. Popescu, Lars Hvilsted Rasmussen, Gianfranco Sinagra, Georghe-Andrei Dan, Aldo P. Maggioni, Luigi Tavazzi, Deirdre A. Lane, Gregory Lip
Journal: Journal of the American College of Cardiology (2016)
Abstract 5190: Biomarkers of sensitivity to PF-03084014, a γ-secretase Inhibitor, in a preclinical model of colorectal cancer
Authors: Rebecca W. Powell, Aik Choon Tan, Marileila Varella-Garcia, Basel Touban, Arvind Dasari, Lauren Puls, Todd Pitts, Gillian Kulikowski, Kevin Quackenbush, Wells Messersmith, John J. Arcaroli
Journal: Cancer Research (2011)

Abstract Purpose: To evaluate the efficacy of PF-03084014, a γ-secretase inhibitor, in a preclinical model of colorectal cancer (CRC) and to identify biomarkers that predicts sensitivity to the compound. Experimental Design: Fourteen patient-derived CRC explants were treated with PF-03084014 (150mg/kg/day- BID) for 28 days. Gene expression of the Notch pathway was evaluated at baseline and day 28 using RT-PCR. Additionally, baseline gene expression profiles were determined using gene array. An Aldefluor assay (stem cell technologies) was used to determine the effect of treatment on tumor initiating cells. Fluorescence in situ hybridization (FISH) was used to determine Notch 1 gene copy number. Results: Three out of the fourteen explants showed sensitivity (cytostatic effects) to PF-03084014. Treatment reduced Notch pathway gene expression (Hes-1, Notch 1, Notch 3, and Jag1) in the sensitive tumors when evaluated by RT-PCR. Baseline gene array data showed an increase in IL-8 gene expression in resistant tumors and pathway analysis demonstrated an increase in focal adhesion, Jack-STAT, and MAPK signaling pathways in resistant explants. Evaluation of the ALDH+ cell population after 28 days of treatment showed that PF-03084014 reduced the ALDH+ cell population in the most sensitive explant (CRC001) when compared to the vehicle group. Evaluation of Notch 1 gene copy number in four CRC explants by FISH showed increased gene copy number in two sensitive explants (CRC027 and CRC001) and one intermediate explant (CRC036) and no gain in gene copy number in one resistant explant (CRC042). Conclusion: Treatment with PF-03084014 significantly reduced tumor growth in three CRC explants. In addition, treatment inhibited expression of the Notch pathway and reduced the tumorigenic ALDH+ population. These results indicate that a subset of patients may derive benefit from treatment with PF-03084014 and biomarkers could be identified that predict sensitivity to the compound. Acknowledgements: This work was supported by a Pfizer IIR grant. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5190. doi:10.1158/1538-7445.AM2011-5190
Author's reply to Steer
Authors: A. Krafft
Journal: BMJ (2013)

I disagree with Steer’s statement that oral iron supplementation in pregnancy has only marginal benefit1 because I think that Haider and colleagues’ study and Pena-Rosas and colleagues’ updated Cochrane review prove the opposite.2 3 4 I do agree, however, that oral iron often has unpleasant side effects and that an entire population should not be exposed to it …
Increased Risk of Endometrial Carcinoma among Users of Conjugated Estrogens
Authors: Harry K. Ziel, William D. Finkle
Journal: New England Journal of Medicine (1975)

The possibility that the use of conjugated estrogens increases the risk of endometrial carcinoma was investigated in patients and a twofold age-matched control series from the same population. Conjugated estrogens (principally sodium estrone sulfate) use was recorded for 57 per cent of 94 patients with endometrial carcinoma, and for 15 per cent of controls. The corresponding point estimate of the (instantaneous) risk ratio was 7.6 with a one-sided 95 per cent lower confidence limit of 4.7. The risk-ratio estimate increased with duration of exposure: from 5.6 for 1 to 4.9 years' exposure to 13.9 for seven or more years. The estimated proportion of cases related to conjugated estrogens, the etiologic fraction, was 50 per cent with a one-sided 95 per cent lower confidence limit of 41 per cent. These data suggest that conjugated estrogens have an etiologic role in endometrial carcinoma. (N Engl J Med 293:1167–1170,1975)
Breast Uptake of Tc-99m Pertechnetate During Perfusion Lung Scan in Pregnancy
Authors: Rathnakara M. Sherigar, James D. Slavin, Harold B. Hawkins, Richard P. Spencer
Journal: Clinical Nuclear Medicine (1998)

A perfusion lung scan (Tc-99m MAA) was performed on a woman during the last month of pregnancy. The posterior view was within normal limits. On the anterior image, considerable activity was seen in the breasts. This was due to free Tc-99m pertechnetate, as shown by activity in both the thyroid and the stomach. The Tc-99m MAA had been made with pertechnetate that was close to its expiration date.
Abstract 4742: Comprehensive epitope mapping of antibodies against CXCR4 and Claudin-4 by Shotgun Mutagenesis
Authors: Cheryl Paes, Joseph Rucker, Yana Thaker, Alex Cameron, Ken Maksimchuk, Riley Payne, Benjamin J. Doranz
Journal: Cancer Research (2012)

Abstract Identifying antibody epitopes on membrane proteins can help differentiate antibody binding mechanisms, identify immunodominant structures, distinguish and classify antibodies, and identify cancer state-specific antigens, providing valuable information for therapeutic and diagnostic applications. However, membrane proteins represent challenging targets for epitope mapping studies using conventional methodologies such as X-ray crystallography or peptide scanning. We have developed a technology, ‘Shotgun Mutagenesis Epitope Mapping’ for rapidly mapping antibody epitopes on structurally-intact proteins expressed in mammalian cells. Here, we applied Shotgun Mutagenesis to create a comprehensive mutation library for CXCR4, a GPCR associated with tumor metastasis. The CXCR4 mutation library, which comprised &amp;gt;700 clones with 2.7x coverage of each of the 352 residues, was screened in triplicate with 5 different anti-CXCR4 MAbs to identify their epitopes. Our analysis revealed that all CXCR4 MAb epitopes were conformational and showed a requirement for charged residues located on the second extracellular loop. CXCR4 MAb epitopes were mapped onto the crystal structure to visualize and identify common structural features. Using epitope information, we generated point mutations in CXCR4 at positions of critical contact residues, incorporated them into virus-like particles (‘Lipoparticles’) and measured their binding kinetics. These approaches helped define the electrostatic contribution of individual amino acid residues on CXCR4 to the association rate, dissociation rate, and overall binding interaction with CXCR4 MAbs. Taking the same approach, we generated a comprehensive mutation library for the biomarker Claudin-4, a tight junction protein upregulated in epithelial cancers. The Claudin-4 mutation library, which comprised &amp;gt;400 clones with complete coverage of each of the 209 residues, was screened with a panel of 7 different anti-Claudin-4 antibodies to map their epitopes. We identified several distinct conformational epitopes that all map exclusively to the large first extracellular loop, identifying this domain as an immunodominant region of claudin-4. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4742. doi:1538-7445.AM2012-4742
Does community care for the mentally ill make a difference? A tale of two cities
Authors: M Beiser, J H Shore, R Peters, E Tatum
Journal: American Journal of Psychiatry (1985)

Matched groups of schizophrenic patients in Portland, Ore., and Vancouver, B.C., were compared approximately 1 year following discharge from an index hospitalization. Whereas Vancouver boasts a rich network of accessible private services and a public mental health system that provides a model of care for the chronically mentally ill, Portland's aftercare facilities at the time of the study were limited. One year after discharge the Vancouver cohort experienced fewer readmissions, was more apt to be employed, and reported a higher level of well-being, all of which suggest that community aftercare positively affects the negative symptoms of schizophrenia.
Role of mathematical concepts in cancer research.
Authors: S Yamamoto
Journal: Environmental Health Perspectives (1979)

The role of mathematics in cancer research is not confined to epidemiology (population level). The expected contribution of it in various levels is exemplified stepwise. At the individual level, prediction of life expectancy of a cancer case or psychological analysis of life-threatened patient; at the tissue level, stochastic estimation of future metastases; at the cellular level, model contruction for abnormal metabolic processes in malignant cell; at the molecular level, elucidation of carcinogenetic mechanism from a thermodynamic standpoint of view.
Proteinuria and Nephrotic Syndrome Associated with Chronic Rejection of Kidney Transplants
Authors: William R. Harlan, Kenton R. Holden, G. Melville Williams, David M. Hume
Journal: New England Journal of Medicine (1967)

THE continuing function of transplanted kidneys depends on the development of a degree of "tolerance" between graft and recipient and the judicious use of immunosuppressive therapy to further this adaptation without disrupting the defense against infection. When major incompatibility exists, there is often an acute systemic response – the acute rejection "crisis" that in most instances responds to massive steroid therapy. Improved immunosuppressive therapy and, more recently, methods of matching graft and recipient have decreased the threat of acute rejection while increasing the incidence of a more subtle expression of incompatibility – the chronic rejection syndrome. Attention has therefore focused . . .
Tl-201 Uptake in Chronic Lymphadenitis
Authors: HITOYA OHTA, MASAYUKI SHINTAKU
Journal: Clinical Nuclear Medicine (2000)

Tl-201 scintigraphy was performed in a 48-year-old woman who previously had a total thyroidectomy for thyroid carcinoma to determine the presence of any metastatic lesions. Abnormal Tl-201 uptake in the right thigh was visualized, and MRI showed an enlarged lymph node. Lymph node metastasis from thyroid carcinoma was considered, but surgery revealed chronic lymphadenitis.
ENVIRONMENT
Authors: JOSEPH D. TEICHER
Journal: American Journal of Psychiatry (1946)

It has been demonstrated how even with a disciplinary activity as the environment, combat-induced emotional disorders will respond without any excess of psychiatric therapy, without group therapy, other than that afforded in group activities, and without special therapeutic measures. All that was required was to afford the individual reasonable security and understanding, have him accept his illness and give him a measure of insight into its dynamics. This has been accomplished in one comprehensive, intensive interview. Then, time (most men were present at least 3 months), the controlled, stable, adjustable environment, and infrequent follow-up interviews do the rest. The environment must be a stable one and no matter how constructively it is utilized and manipulated, it is fundamental to success that each subject receive a measure of individual treatment. Upon this individual psychotherapy hinges the best utilization of any stable environment which can only be a valuable adjunct.
Dynamic and Static Cerebral Perfusion Scintigraphy of Cerebral Arteriovenous Malformations
Authors: NOBUYOSHI FUKUMITSU, DAISUKE TSUCHIDA, SHIGEYUKI OGI, MAYUKI UCHIYAMA, YUTAKA MORI
Journal: Clinical Nuclear Medicine (2003)

FUKUMITSU, NOBUYOSHI M.D.; TSUCHIDA, DAISUKE M.D.; OGI, SHIGEYUKI M.D.; UCHIYAMA, MAYUKI M.D.; MORI, YUTAKA M.D. Author Information
FRI0045 Performance of New Anti-Ccp Multiplexing Assay Comparing to ELISA Anti-Ccp3 Test
Authors: S.S. Salah, D. Fodil, M. Benidir, C. Makhloufi Dahou, M. Bayou, S. Mostefai, M.C. Abbadi, N. Attal
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> ACPA finds its place in early RA diagnosis. Improvements are made in measurement of ACPA with recently designed fluorescent-based microparticles immunoassay which allows the simultaneous detection of 4 anti-CCP autoantibody specificities: anti-HCP1, anti-HCP2, anti-VCP1 and anti-VCP2. <h3>Objectives</h3> The aim of this work is to evaluate the performance of new anti-CCP multiplexing assay comparing to anti-CCP3 ELISA test. <h3>Methods</h3> Detection and measurement of ACPA by FIDIS™ anti-CCP (Theradiag) multiplexing assay were compared to the anti-CCP3 ELISA (INOVA) in 171 [98 anti-CCP3 (+), 73 anti-CCP3 (-)] sera patients with early arthritis. <h3>Results</h3> Global concordance was about 81% between FIDIS anti-CCP and anti-CCP3 (Table 1 and Table 2) while, for each of four FIDIS citrullinated peptides, this concordance is shown on Table 2. We observed a good concordance between two tests. Otherwise, it is noteworthy that among anti-CCP3 (-) patients, 17 (23%) were FIDIS anti-CCP (+). Among them, 53% recognize 1 citrullinated peptide, 35% 2 peptides and 6% 3 or 4 peptides. Thus, the FIDIS anti-CCP test increases the sensitivity of detection of ACPA compared to anti-CCP3 that have proven good diagnostic performance. However, some specificities are not detected by the new method comparatively to anti-CCP3. <h3>Conclusions</h3> FIDIS anti-CCP multiplexing assay shows good performance comparing to anti-CCP3 and must be assessed on larger series of patients with early RA compared to control populations. <h3>References</h3> Anzilotti C, Merlini G, Pratesi F, Tommasi C, Chimenti D, Migliorini P. Antibodies to viral citrullinated peptide in rheumatoid arthritis. J Rheumatol. 2006 Apr;33(4):647-51.Pratesi F., Tommasi C., Anzilotti C., Puxeddu I., Sardano E., Di Colo G., Migliorini P. Antibodies to a new viral citrullinated peptide, VCP2: fine specificity and correlation with anti-cyclic citrullinated peptide (CCP) and anti-VCP1 antibodies. Clin. Exp. Immunol. 2011, 164, 337. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6049
Twenty year follow-up of ACL reconstruction (<i>AJSM</i>)—the evidence of experience
Authors: Bob McCormack, Mark R Hutchinson
Journal: British Journal of Sports Medicine (2016)

As clinicians and academics, we are challenged to sift through a myriad of publications with the key goal and purpose of assessing whether the quality of the data and research is good enough to have an impact on the way we practice and on our responsibility to optimise the care of our patients.1–6 Various categorisations of the quality of evidence are available with one of the classics being level of evidence 1 used for high-quality randomised control trials, level of evidence 2 for prospective cohort studies, level of evidence 3 for cohort studies, level of evidence 4 for descriptive case series, and level of evidence 5 for ‘expert’ opinion.

For some, systematic reviews and meta-analyses have taken a pre-eminent place in the hierarchy of evidence superseding even a high-quality, well-targeted, randomised control trial. However, one must bear in mind that the weak link of any systematic review/meta-analysis is the fact that the authors may not have performed …
Induced knockouts provide insights into human L1 syndrome
Authors: Jan Pielage
Journal: The Journal of Experimental Medicine (2016)

3 4 i n s i g h t 1 _ F i g 1 .j p e g < / I D > Unraveling the cellular changes elicited by pathogenic mutations is central to the development of novel targeted therapeutics.In this issue, < a d d a r t t y p e = " r e l " d o i = " 1 0 . 1 0 8 4 / j e m . 2 0 1 5 0 9 5 1 " > Patzke et al.< / a d d a r t > use advanced stem cell technologies to underscore the role of human L1CAM for neuronal development and function.Mutations in the cell adhesion molecule L1CAM cause neurological alterations, including severe intellectual disabilities summarized as L1 syndrome.The requirements of L1CAM for neuronal development have been characterized extensively using in vitro, cell culture, and mouse model systems, which have implicated L1CAM in numerous signaling pathways with essential roles for neurite outgrowth, axon guidance, and synaptic transmission.However, distinct differences remain between the phenotypic strength of mouse models and clinical presentations in human patients.
P433 IS TIPS INDICATED IN CIRRHOTIC PATIENTS WITH CHILD–PUGH B SCORE AND ACTIVE VARICEAL BLEEDING?
Authors: R. Sia, J. Scanzi, B. Pereira, R.A. Sombié, A.K. Sermé, P.D. Ilboudo, S.H.M. Godonou, L. Poincloux, M. Dapoigny, G. Lamblin, G. Bommelaer, A. Abergel
Journal: Journal of Hepatology (2014)
MULTI-CENTER POST-MARKET REGISTRY FOR THE EVALUATION OF ROBOTIC ASSISTED PCI
Authors: Ryan Madder, Paul Campbell, Ehtisham Mahmud, David Wohns, Tomasz Stys, Ronald Caputo, Mark Leimbach, Manish Parikh, Vijaykumar Kasi, Giora Weisz
Journal: Journal of the American College of Cardiology (2016)
FDG-PET Scan in the Diagnosis of Postmeningococcal Pericarditis
Authors: DANIEL BLOCKMANS, SIGRID STROOBANTS, STEVEN VANDERSCHUEREN, WILLY PEETERMANS, HERMAN BOBBAERS, LUC MORTELMANS
Journal: Clinical Nuclear Medicine (2002)

BLOCKMANS, DANIEL M.D., Ph.D.; STROOBANTS, SIGRID M.D.; VANDERSCHUEREN, STEVEN M.D., Ph.D.; PEETERMANS, WILLY M.D., Ph.D.; BOBBAERS, HERMAN M.D., Ph.D.; MORTELMANS, LUC M.D., Ph.D. Author Information
Abstract 1276: TRAIL-induced p38 activation responsible for increases of Akt catalytic and Invasive activity
Authors: Bo K. Sun, Joo-Hang Kim, So Y. Kim, Seeun Oh, Hye J. Choi, Joo-Hyuk Sohn, Yong J. Lee, Jae J. Song
Journal: Cancer Research (2010)

Abstract In this paper, we demonstrate that TRAIL-induced p38 activation is responsible for the increases of Akt catalytic activity and invasive activity. For the confirmation of increases of Akt catalytic and invasive activity induced by TRAIL-induced p38 activation, immune complex kinase assay and invasion assay was used. Previously, we observed that TRAIL induces acquired TRAIL resistance with increased Akt phosphorylation resulting from Src-PI3K-Akt signaling pathways mediating by c-Cbl. c-Cbl, an ubiquitously expressed cytoplasmic adaptor protein was shown to be involved in the rapid degradation of TRAIL receptors and simultaneously in the Akt phosphorylation during TRAIL treatment. However, Akt phosphorylation did not have an exclusive role for acquired TRAIL resistance. Like Akt catalytic activation during metabolic oxidative stress, TRAIL induced dramatically Akt catalytic activation in TRAIL-sensitive cells, whereas TRAIL did not induce Akt catalytic activation in TRAIL-resistant cells, suggesting Akt catalytic activation during TRAIL-induced apoptosis is likely to have a role of compensation for cell homeostasis. Our studies also reveal that p38 activation during TRAIL treatment is responsible for the increases of Akt catalytic and invasive activity. Bo K. Sun and Joo-Hang Kim are equally contributed to this work. Correspondence: Jae J Song (jjs109@yuhs.ac) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1276.
P119 COPD assessment test scores: short-term changes during recovery from COPD exacerbation
Authors: S. Chandramouli, S. Huq, J. Lagan, L. Davies
Journal: Thorax (2010)

<h3>Introduction</h3> The COPD assessment test (CAT) is a brief questionnaire that seems to serve as a reliable measure of COPD health status. (1). Little is known about CAT scores in patients in the UK hospitalised with COPD exacerbations and the impact of factors such as age, COPD severity and co-morbidities on CAT scores during recovery. <h3>Aims</h3> To record CAT scores in patients hospitalised with COPD exacerbations. To assess the impact of age, FEV<sub>1</sub> and co-morbidities on CAT score improvements. <h3>Methods</h3> A random selection of patients presenting to our hospital between December 2009 and June 2010 with a clinical diagnosis of COPD exacerbation were approached. Those with radiological or clinical evidence of pneumonia, lung malignancy and bronchiectasis were excluded. All patients had evidence of fixed airflow obstruction on previous spirometry obtained from out-patient clinic visits and were current or ex smokers. Baseline demographics were recorded and patients were asked to complete CAT questionnaires on day 0 (day of hospital admission), day 2 and day 7.Questionnaires were completed at the bedside or, in those discharged, over the telephone. Charlson Comorbidity Indices (CCI) were calculated, using information from hospital case notes. <h3>Results</h3> 83 patients (52 female) with a mean (SD) age of 67 (11) years and mean FEV<sub>1</sub> of 43% (18) predicted were recruited. The median (range) CCI score was 4 (1–11). Mean (SD) CAT scores on days 0, 2 and 7 were 30.6 (5.8), 28.3 (6.7) and 26.4 (7.2) units respectively. The difference in scores between days 0 and 2 was −2.4 units (paired t-test, p&lt;0.0001) and between days 0 and 7 was −4.2 units (p&lt;0.0001). See Abstract P119 Table 1 for correlation co-efficients. <h3>Conclusions</h3> Mean CAT scores in this group of hospitalised patients were very high in keeping with our previous studies in similar patients who had high St George9s Respiratory Questionnaire scores. (2). CAT scores improve significantly as early as 2 days after treatment for an exacerbation and improve further by day 7. In our cohort, there was no significant correlation between improvement in CAT scores and age, FEV<sub>1</sub> or CCI. Larger studies are needed to examine these relationships in more depth.