tbuckley/cabot-search huggingface dataset:
The Bruton's Tyrosine Kinase (BTK) Inhibitor PCI-32765 Induces Durable Responses in Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL): Follow-up of a Phase Ib/II Study
Authors: Susan O'Brien, Jan A. Burger, Kristie A. Blum, Richard R. Furman, Steven E. Coutre, Jeff Sharman, Ian W. Flinn, Barbara Grant, Nyla A. Heerema, Amy J. Johnson, Tasheda Navarro, Eric Holmgren, Eric Hedrick, John C. Byrd
Journal: Blood (2011)
Vav1 Regulates Perivascular Homing, Bone Marrow Retention and Engraftment of Hematopoietic Stem Cells Via SDF1a Signaling
Authors: Abel Sanchez-Aguilera, Yun-Jung Lee, Cristina Lo Celso, Francesca Ferraro, Kristina Brumme, Subhanjan Mondal, Chaekyun Kim, Dorrance Adrienne, Hongbo R. Luo, David T. Scadden, David A. Williams
Journal: Blood (2010)
Hemodynamics. PCO2 gradient
Authors: A. Dive, P. Evrard, M. Gonzalez, J. Jamart, E. Installé, J. P. Revelly, R. Chioléro, D. Bracco, R. Neviere, D. Mathieu, F. Herengt, F. Wattel, J. L. Teboul, R. Boujdaria, A. Mercat, J. Depret, Ph. Auzepy, Ch. Richard, G. Berlot, H. Zhang, J. L. Vincent, A. Meier-Hellmann, L. Hannemann, D. Weyand, W. Heiss-Dunlop, H. Hassel, K. Reinhart
Journal: Intensive Care Medicine (1992)
IMPAIRED BIOSYNTHESIS OF PHOSPHATIDYLCHOLINE LEADS TO THE FORMATION OF RELATIVELY LARGER, LIPID-RICH VERY LOW-DENSITY LIPOPROTEINS WITH ALTERED CONFORMATION OF APOLIPOPROTEIN-B
Authors: Henkjan Verkade, Ae Rusinol, Dg Fast, Dg Scraba, De Vance
Journal: Circulation (1992)
Favorable Influence of Pretransplant Rituximab but Not of High-Dose Ara-C in Upfront Autologous Stem Cell Transplantation (SCT) for Mantle Cell Lymphoma (MCL).
Authors: Michael Rieger, Manfred Hensel, Baerbel Seyfarth, Soeren Sitter, Simona Martin, Rainer Haas, Michael Kneba, Norbert Schmitz, Anthony D. Ho, Peter Dreger
Journal: Blood (2005)
Case 2-2017
Authors: Kristian R. Olson, Amir H. Davarpanah, Esperance A. Schaefer, Nahel Elias, Joseph Misdraji
Journal: New England Journal of Medicine (2017)

An 18-year-old woman presented with acute liver failure. The total bilirubin was 19.7 mg per deciliter. Three days earlier, she had received a diagnosis of bronchitis and was treated with azithromycin. A diagnosis was made.
Cdx4 Is Dispensable for Murine Hematopoiesis and MLL-AF9 Mediated Leukemogenesis.
Authors: Sumin Koo, Thomas Mercher, Shannon Mckinney- Freeman, Yuan Wang, Brian Ball, Brian JP Huntly, Dimple Bansal, George Q. Daley, D. Gary Gilliland
Journal: Blood (2008)
Combination of Indoleamine 2,3-Dioxygenase Expression and L-Kynurenine Level Can Identify Truly Poor Prognosis Patients with Diffuse Large B-Cell Lymphoma
Authors: Soranobu Ninomiya, Nobuhiro Kanemura, Hisashi Tsurumi, Naoe Goto, Ryoko Mabuchi, Nobuhiko Nakamura, Hiroshi Nakamura, Senji Kasahara, Takeshi Hara, Tsuyoshi Takami, Hisataka Moriwaki
Journal: Blood (2011)
Twisted Gastrulation (TWSG1) Is Expressed at Elevated Levels in Thalassemia and Regulates Bone Morphogenic Protein Signaling.
Authors: Toshihiko Tanno, Prashanth Porayette, Ajoy Bhupatiraju, Pamela Staker, Y. Terry Lee, Suthat Fucharoen, Robert F. Paulson, Jeffery L. Miller
Journal: Blood (2007)
Neuropilin-1 – Novel, Promising Target for Chronic Lymphocytic Leukemia patients.
Authors: Krzysztof Giannopoulos, Marcin Omiotek, Radosław Mlak, Waldemar Tomczak, Jacek M. Rolinski, Anna Dmoszynska, Stephan Stilgenbauer, Lars Bullinger
Journal: Blood (2009)
Molecular Allelo-Karyotyping of Adult T-Cell Leukemia Using High SNP Genotyping Microarrays.
Authors: Satsuki Muto, Go Yamamoto, Yasuhito Nannya, Masashi Sanada, Nazanin Dabaghmanesh, Takaomi Ishida, Atae Utsunomiya, Yasuaki Yamada, Shimeru Kamihira, Kazunari Yamaguchi, Toshiki Watanabe, Seishi Ogawa
Journal: Blood (2007)
Use of a Super-Saturated Calcium Phosphate Mouth Rinse for Prevention and Treatment of Oral Mucositis Results In Faster Engraftment and Hospital Discharge Than Using a Sodium Bicarbonate Rinse Alone After Autologous Transplantation
Authors: Justin Oh, Sung Hoon Hong, Ilana Yablonovich, Michele L Donato, Andrew L Pecora, Stuart L. Goldberg, David H. Vesole, David S. Siegel, Tatyana Feldman, Andre Goy, Anthony R Mato, Joshua R. Richter, Scott D Rowley
Journal: Blood (2011)
Minimal Residual Disease Status Is the Most Important Preditive Factor in Adults with Acute Lymphoblastic Leukemia. Prospective, Multicenter PALG 4-2002 MRD Study.
Authors: Jerzy Holowiecki, Malgorzata Krawczyk-Kulis, Sebastian Giebel, Krystyna Jagoda, Beata Stella-Holowiecka, Beata Jakubas, Monika Paluszewska, Ilona Seferynska, Anna Czyz, Wlodzimierz Mendrek, Aleksander Skotnicki, Wieslaw W. Jedrzejczak, Krzysztof Warzocha, Lech Konopka, Andrzej Hellmann
Journal: Blood (2007)
PIM2 Kinase Regulates T-Cell Alloresponses and Graft-Versus-Host Disease in Mice
Authors: Yongxia Wu, Anusara Daenthanasanmak, Hung Nguyen, Jessica Lauren Heinrichs, David Bastian, Shikhar Mehrotra, Andrew Kraft, Xue-Zhong Yu
Journal: Blood (2015)
A Novel Quantitative PCR Approach Targeting Insertion/Deletion Polymorphisms (Indel-PCR) for Chimerism Quantification: Finally High Sensitivity and Quantification Capacity Together
Authors: Almudena Navarro-Bailón, Carolina Martinez-Laperche, Diego Carbonell, Elena Buces, Milagros González-Rivera, Mariana Bastos, Pascual Balsalobre, Mi Kwon, David Serrano, Javier Anguita, Jorge Gayoso, Jose Luis Diez-Martin, Ismael Buño
Journal: Blood (2015)
ELANE Mutations in Cyclic and Congenital Neutropenia: Genotype-Phenotype Relationships,
Authors: David C. Dale, Vahagn Makaryan, Audrey Anna Bolyard, Elin R. Rodger, Merideth L. Kelley, Tracy M. Marrero, Lan Phan, Andrew A Aprikyan, Mary Ann Bonilla, Peter E. Newburger, Laurence A. Boxer, Daniel Link
Journal: Blood (2011)
Long-Term Treatment and Tolerability of the Novel Proteasome Inhibitor Carfilzomib (CFZ) In Patients with Relapsed and/or Refractory Multiple Myeloma (R/R MM)
Authors: Sundar Jagannath, Ravi Vij, Jonathan L. Kaufman, Thomas Martin, Ruben Niesvizky, Nashat Y Gabrail, Melissa Alsina, Alvin F. Wong, Mai H. Le, Leanne McCulloch, Alison L. Hannah, Michael Kauffman, David Samuel diCapua Siegel
Journal: Blood (2010)
FDG Uptake by Prosthetic Arterial Grafts in Large Vessel Vasculitis Is Not Specific for Active Disease
Authors: Taryn Youngstein, Enrico Tombetti, Jaita Mukherjee, Tara D. Barwick, Adil Al-Nahhas, Emyr Humphreys, Julian Nash, Jacqueline Andrews, Elena Incerti, Elisabetta Tombolini, Annalaura Salerno, Silvia Sartorelli, Giuseppe A. Ramirez, Maurizio Papa, Maria Grazia Sabbadini, Luigi Gianolli, Francesco De Cobelli, Federico Fallanca, Elena Baldissera, Angelo A. Manfredi, Maria Picchio, Justin C. Mason
Journal: JACC. Cardiovascular imaging (2017)
A Novel Aurora-a Kinase Inhibitor MLN8237 Induces Cytotoxicity and Cell Cycle Arrest in Experimental Multiple Myeloma Models.
Authors: Gullu Gorgun, Elisabetta Calabrese, Mala Mani, Teru Hideshima, Hiroshi Ikeda, Giulia Perrone, Loredana Santo, Diana Cirstea, Simona Blotta, Paul G. Richardson, Jeffrey Ecsedy, Kenneth C. Anderson
Journal: Blood (2008)
SRSF2 is Mutated in 47.2% (77/163) of Chronic Myelomonocytic Leukemia (CMML) and Prognostically Favorable in Cases with Concomitant RUNX1 mutations
Authors: Susanne Schnittger, Manja Meggendorfer, Alexander Kohlmann, Vera Grossmann, Kenichi Yoshida, Seishi Ogawa, H. Phillip Koeffler, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach
Journal: Blood (2011)
Effects of the Mcl-1/Bcl-2 Inhibitor GX015-070 (Obatoclax®) on Growth and Viability of Canine and Human Neoplastic Mast Cells
Authors: Barbara Peter, Karl J. Aichberger, Karoline V. Gleixner, Veronika Ferenc, Alexander Gruze, Winfried F. Pickl, Michael Willmann, Peter Valent
Journal: Blood (2008)
A Pilot Study of Sleep Disordered Breathing (SDB) and Nocturnal Hypoxemia in Young Adults with Sickle Cell Disease
Authors: Susan P. Perrine, Oluwakemi Owoyemi, Elizabeth S Klings, Mehdi Nouraie, Angela Rock, Patricia A. Oneal, Thomas Mellman, Tessema Berihun, Peter L. Whitesell, Joseph Lavela, Robert E. Taylor
Journal: Blood (2015)
Genetics of ancestry-specific risk for relapse in acute lymphoblastic leukemia
Authors: S E Karol, E Larsen, C Cheng, X Cao, W Yang, L B Ramsey, C A Fernandez, J R McCorkle, S W Paugh, R J Autry, E Lopez-Lopez, B Diouf, S Jeha, C-H Pui, E A Raetz, N J Winick, W L Carroll, S P Hunger, M L Loh, M Devidas, W E Evans, J J Yang, M V Relling
Journal: Leukemia (2017)
Spontaneous Intracranial Hypotension With Site of Leak Detected Only After 111In-DTPA Cisternogram
Authors: Sana Parsian, Manuela C. Matesan, Sachin Shivaji Kumbhar, David H. Lewis
Journal: Clinical Nuclear Medicine (2017)

A 54-year-old man with a 3-week history of orthostatic headache and acute on chronic subdural hematoma presented with imaging findings suggestive of spontaneous intracranial hypotension. Three myelograms were negative for leak, and nontargeted epidural blood patches did not result in symptom relief. A cerebrospinal fluid leak study using In-DTPA with SPECT/CT demonstrated a focal area of asymmetric activity at the left C2 nerve root. A left C2 root tie-off, targeted epidural blood patch, and Dura seal glue resulted in resolution of patient symptomatology highlighting the importance of fused SPECT/CT images in detection of an occult cerebral spinal fluid leak.
Variations in Proteasome Enzymatic Activities in Plasma of Patients with Acute Myeloid Leukemia and Myelodysplastic Syndrome and Their Value in Predicting Clinical Behavior.
Authors: Wanlong Ma, Francis Giles, Susan O’Brien, Iman Jilani, Xi Zhang, Zeev Estrov, Elihu Estey, Alessandra Ferrajoli, Michael Keating, Maher Albitar
Journal: Blood (2006)
The AKT Inhibitor, A443654, Induces Cell Cycle Arrest, Apoptosis and Synergizes with Chemotherapeutic Drugs in Multi-Drug Resistant T-Cell Acute Lymphoblastic Leukemia - A Novel Agent for Therapy of Drug Resistant ALL.
Authors: James A. McCubrey, William L. Blalock, Pier Luigi Tazzari, Alessandra Cappellini, Ilaria Iacobucci, Francesca Chiarini, Steve L. Abrams, Emanuela Ottaviani, Giovanni Martinelli, Agostino Tafuri, Lucio Cocco, Alberto M. Martelli, Federica Fala
Journal: Blood (2007)
Differential PI3Kδ Signaling in CD4+ T-cell Subsets Enables Selective Targeting of T Regulatory Cells to Enhance Cancer Immunotherapy
Authors: Shamim Ahmad, Rasha Abu-Eid, Rajeev Shrimali, Mason Webb, Vivek Verma, Atbin Doroodchi, Zuzana Berrong, Raed Samara, Paulo C. Rodriguez, Mikayel Mkrtichyan, Samir N. Khleif
Journal: Cancer Research (2017)

To modulate T-cell function for cancer therapy, one challenge is to selectively attenuate regulatory but not conventional CD4+ T-cell subsets [regulatory T cell (Treg) and conventional T cell (Tconv)]. In this study, we show how a functional dichotomy in Class IA PI3K isoforms in these two subsets of CD4+ T cells can be exploited to target Treg while leaving Tconv intact. Studies employing isoform-specific PI3K inhibitors and a PI3Kδ-deficient mouse strain revealed that PI3Kα and PI3Kβ were functionally redundant with PI3Kδ in Tconv. Conversely, PI3Kδ was functionally critical in Treg, acting there to control T-cell receptor signaling, cell proliferation, and survival. Notably, in a murine model of lung cancer, coadministration of a PI3Kδ-specific inhibitor with a tumor-specific vaccine decreased numbers of suppressive Treg and increased numbers of vaccine-induced CD8 T cells within the tumor microenvironment, eliciting potent antitumor efficacy. Overall, our results offer a mechanistic rationale to employ PI3Kδ inhibitors to selectively target Treg and improve cancer immunotherapy. Cancer Res; 77(8); 1892-904. ©2017 AACR.
Brief Report: Sex Ratio of Offspring Born to Women With Systemic Lupus Erythematosus or Rheumatoid Arthritis
Authors: Elizabeth V. Arkema, Johan Askling, Jane E. Salmon, Julia F. Simard
Journal: Arthritis & Rheumatology (2016)

To determine whether the sex ratio among offspring born to women with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) is different from that in the general population.Women with a singleton delivery were identified from the Swedish Medical Birth Register (1973-2012) and linked to the National Patient Register (1964-2012) to identify those with prevalent SLE or RA. A sample of general population comparators was identified from the Swedish Total Population Register. We calculated the percentages of males born to women with SLE, women with RA, and women in the general population, as well as the risk ratio (RR) for having a male child among first births and all births. We also examined a history of antiphospholipid syndrome in the SLE population, using International Classification of Disease codes before or at delivery.We identified 661 women with SLE and 1,136 women with RA before their first delivery. There were a total of 1,401 deliveries to women with SLE and a total of 2,674 deliveries to women with RA. Compared with women in the general population, women with SLE and those with RA had a lower risk of having a first-born male (RR 0.92 [95% confidence interval 0.85-1.00] and RR 0.93 [95% confidence interval 0.87-0.99], respectively). Among all births, the percentage of male offspring remained lower than that in the general population, but the difference was not statistically significant for RA.The proportion of male offspring born to women with prevalent SLE or RA at delivery was lower than that in the general population, although the difference was small. Chronic inflammation may affect the sex ratio through fetal loss in early gestation.
The epidermal polarity protein Par3 is a non–cell autonomous suppressor of malignant melanoma
Authors: Melina Mescher, Peter Jeong, Sina K. Knapp, Matthias Rübsam, Michael Saynisch, Marina Kranen, Jennifer Landsberg, Max Schlaak, Cornelia Mauch, Thomas Tüting, Carien M. Niessen, Sandra Iden
Journal: The Journal of Experimental Medicine (2017)

Melanoma, an aggressive skin malignancy with increasing lifetime risk, originates from melanocytes (MCs) that are in close contact with surrounding epidermal keratinocytes (KCs). How the epidermal microenvironment controls melanomagenesis remains poorly understood. In this study, we identify an unexpected non-cell autonomous role of epidermal polarity proteins, molecular determinants of cytoarchitecture, in malignant melanoma. Epidermal Par3 inactivation in mice promotes MC dedifferentiation, motility, and hyperplasia and, in an autochthonous melanoma model, results in increased tumor formation and lung metastasis. KC-specific Par3 loss up-regulates surface P-cadherin that is essential to promote MC proliferation and phenotypic switch toward dedifferentiation. In agreement, low epidermal PAR3 and high P-cadherin expression correlate with human melanoma progression, whereas elevated P-cadherin levels are associated with reduced survival of melanoma patients, implying that this mechanism also drives human disease. Collectively, our data show that reduced KC Par3 function fosters a permissive P-cadherin-dependent niche for MC transformation, invasion, and metastasis. This reveals a previously unrecognized extrinsic tumor-suppressive mechanism, whereby epithelial polarity proteins dictate the cytoarchitecture and fate of other tissue-resident cells to suppress their malignant outgrowth.
A Phase 1, Open-Label, Dose-Escalation Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of Oral Azacitidine in Patients with Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML).
Authors: Guillermo Garcia-Manero, Steven D. Gore, Barry Skikne, Christopher R. Cogle, Yuhong Ning, Kyle J MacBeth, Eric Laille, M. Renee Ward
Journal: Blood (2009)
Multiple CMV Reactivations Are Associated with Lower Risk of Relapse Following Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation
Authors: Feras Alfraih, Naheed Alam, Vikas Gupta, Dennis Dong Hwan Kim, John Kuruvilla, Jeffrey H. Lipton, David Loach, Matthew D. Seftel, Jieun Uhm, Anna Lambie, Hans A. Messner
Journal: Blood (2014)
Confirmation of Safety, Efficacy and Response Duration in Non-Hodgkin Lymphoma Patients Treated with 60 μg/m2/d of BiTE® Antibody Blinatumomab.
Authors: Dirk Nagorsen, Gerhard Zugmaier, Andreas Viardot, Mariele Goebeler, Richard Noppeney, Margit Schmidt, Petra Klappers, Patrick A Baeuerle, Peter Kufer, Ralf C Bargou
Journal: Blood (2009)
Outbreak of Salmonella serotype Saintpaul infections associated with eating alfalfa sprouts - United States, 2009.
Authors: T. Safranek, D. Leschinsky, A. Keyser, A. O'Keefe, T. Timmons, S. Holmes, A. Garvey, D. von Stein, M. Harris, P. Quinlisk, S. A. Bidol, K. D. Sheline, J. M. Collins, R. Vorhees, J. Stella, S. Ostroff, C. Marriott, C. Sandt, W. Chmieleski, J. Lando, L. Saathof-Huber, S. Anderson, E. Hedican, S. Meyer, K. Smith, S. Miller
Journal: MMWR Morbidity and Mortality Weekly Report (2009)
Continuous Immuno-Chemotherapy Followed by High Dose and Autologous Cell Transplantation May Improve the Event-Free-Survival in Mantle Cell Lymphoma Patients. Experience at the European Institute of Oncology in Milan.
Authors: Simona Bassi, Alessandra Alietti, Chiara Corsini, Federica Gigli, Paola Bertazzoni, Cristina Rabascio, Patrizia Mancuso, Emilia Cocorocchio, Daniele Laszlo, Giancarlo Pruneri, Lorenzo Preda, Sarah J. Liptrott, Rosaria Cascio, Francesco Bertolini, Giovanni Martinelli
Journal: Blood (2007)
The EBV Oncogene LMP1 Protects Lymphoma Cells From Cell Death Through The Collagen-Mediated Activation Of Discoidin Domain Receptor 1
Authors: Fathima Zumla Cader, Martina Vockerodt, Shikha Bose, Eszter Nagy, Marie-Anne Brundler, Pamela R Kearns, Paul G Murray
Journal: Blood (2013)
Different Contribution of Hematopoietic and Somatic Cell Types Expressing FcRn to the Prolonged Half-Life of Recombinant Factor VIII Fc and Recombinant FIX Fc
Authors: Arjan van der Flier, Zhan Liu, Douglas Drager, Sebastien Vallee, Kai Chen, Siyuan Tan, Keith Wharton, David R. Light, Haiyan Jiang
Journal: Blood (2012)
Multicentre Phase I Study with an 8-Dose Regimen of Single Agent Anti-CD20 Monoclonal Antibody LFB-R603 in Patients with Relapsed Chronic Lymphocytic Leukemia (CLL)
Authors: Bruno Cazin, Stéphane Leprêtre, Bertrand Coiffier, Thérèse Aurran, Guillaume Cartron, Pierre Feugier, Oana Brehar, Alain Sadoun, Fédéric Segaud, Vincent Ribrag
Journal: Blood (2011)
Peripheral Blood CD3+CD4+ and CD3−CD56+ Cell Counts and Circulating Lymphoma Cells Are Significant Predictors of Overall Survival in Newly Diagnosed Follicular Lymphoma.
Authors: Danielle Shafer, Mitchell R. Smith, Samuel Litwin, Tianyu Li, Hossein Borghaei, Tahseen I. Al-Saleem
Journal: Blood (2007)
Cyclophosphamide, Adriamycin, Vincristine and Prednisone Plus Rituximab (CHOP-R) in Fludarabine (F) Refractory Chronic Lymphocytic Leukemia (CLL) or CLL with Autoimmune Cytopenia (AIC) or Richter's Transformation (RT): Final Analysis of a Phase II Study of the German CLL Study Group
Authors: Petra Jenke, Barbara Eichhorst, Raymonde Busch, Nadine Anheier, Ulrich Duehrsen, Jan Duerig, Martin H. Dreyling, Manuela Bergmann, Maria Elisabeth Goebeler, Hans Juergen Hurtz, Martina Beate Stauch, Stephan Stilgenbauer, Hartmut Doehner, Anna-Maria Fink, Kirsten Fischer, Clemens-Martin Wendtner, Michael Hallek
Journal: Blood (2011)
HLA-Matched Sibling Stem Cell Transplantation Using Conditioning Regimen with Reduced Dose of Cyclophosphamide, ATG and Fludarabine in Patients with Severe Aplastic Anemia
Authors: Jong Wook Lee, Byung Sik Cho, Yoo Jin Kim, Seok Lee, Hee Je Kim, Chang Ki Min, Seok Goo Cho, Dong Wook Kim, Woo Sung Min, Chong Won Park, Chun-Choo Kim
Journal: Blood (2008)
Endoscopic ultrasound-guided biliary access versus precut papillotomy in patients with failed biliary cannulation: a retrospective study
Authors: Alexander Lee, Anupam Aditi, Yasser Bhat, Kenneth Binmoeller, Chris Hamerski, Oriol Sendino, Steve Kane, John Cello, Lukejohn Day, Medi Mohamadnejad, V. Muthusamy, Rabindra Watson, Jason Klapman, Sri Komanduri, Sachin Wani, Janak Shah
Journal: Endoscopy (2017)

<b>Background and aims</b> Precut papillotomy is widely used after failed biliary cannulation. Endoscopic ultrasound (EUS)-guided biliary access techniques are newer methods to facilitate access and therapy in failed cannulation. We evaluated the impact of EUS-guided biliary access on endoscopic retrograde cholangiopancreatography (ERCP) success and compared these techniques to precut papillotomy. <b>Patients and methods</b> We retrospectively compared two ERCP cohorts. One cohort consisted of biliary ERCPs (n = 1053) attempted in patients with native papillae and surgically unaltered anatomy in whom precut papillotomy and/or EUS-guided biliary access were routinely performed immediately after failed cannulation. This cohort was compared with a similar ERCP cohort (n = 1062) in which only precut papillotomy was available for failed cannulation. The following outcomes were compared: conventional cannulation success, rates of attempted advanced access techniques (precut or EUS), precut success, EUS-guided biliary access success, and ERCP failure rates. <b>Results</b> Although conventional cannulation success, rates of attempted advanced access technique (precut or EUS), and precut success were similar, the ERCP failure rate was lower when both EUS-guided biliary access and precut were available (1.0 % [95 % confidence interval (CI) 0.4 – 1.6]), compared with when only precut was possible for failed access (3.6 % [95 %CI 2.5 – 4.7]; <i>P</i> < 0.001). Success for EUS-guided biliary access (95.1 % [95 %CI 89.7 – 100]) was significantly higher than for precut (75.3 % [95 %CI 68.2 – 82.4]; <i>P</i> < 0.001), and mainly due to superiority in malignant obstruction (93.5 % vs. 64 %; <i>P</i> < 0.001). <b>Conclusions </b>EUS-guided biliary access decreases the rate of therapeutic biliary ERCP failure. Our results support the use of EUS-guided biliary access to optimize single-session ERCP success. In experienced hands, these techniques appear as effective, if not more so, than precut papillotomy.
Clinicopathologic Characterization of Acute Myeloid Leukemia and Myelodysplastic Syndrome with Inv(3)(q21q26.2)/t(3;3)(q21;q26.2) Reveals That Complex Karyotype but Not Blast Percentage Is Associated with Poor Survival; A Bone Marrow Pathology Group Study
Authors: Heesun J. Rogers, James W. Vardiman, John Anastasi, Gordana Raca, Natasha M Savage, Athena M Cherry, Daniel Arber, Erika Moore, Jennifer JD Morrissette, Adam Bagg, Yen-Chun Liu, Susan Mathew, Attilio Orazi, Pei Lin, Sa A. Wang, Carlos E. Bueso-Ramos, Kathryn Foucar, Robert P Hasserjian, Eric D. Hsi
Journal: Blood (2012)
Role of TORC1 and TORC2 in Multiple Myeloma
Authors: Patricia Maiso, Yi Liu, Abdel Kareem Azab, Brittany Morgan, Feda Azab, Antonio Sacco, Michaela Reagan, Hai T Ngo, Yang Liu, Yong Zhang, Charles Lin, Aldo M Roccaro, Christian Rommel, Irene M. Ghobrial
Journal: Blood (2011)