tbuckley/cabot-search huggingface dataset:
EVALUATION OF GYNECOLOGIC SURGERY IN THERAPY OF INFERTILITY
Authors: B CARTER, V H TURNER, C D DAVIS, E C HAMBLEN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB1218-HPR Fatigue-Related Communication in Rheumatic Diseases: The Patient Perspective
Authors: C. Bode, C. Cordesmeyer, P.T. Klooster
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Severe fatigue is prevalent in patients with rheumatic diseases and has significant impact on patients "quality of life". However, qualitative studies revealed that fatigue symptoms remain undiscussed in the consultations with health professionals. <h3>Objectives</h3> Aim of this study was to describe the perceived importance of, satisfaction with and efficacy in fatigue-related communication with rheumatologists and rheumatology nurses from the perspective of the patient and to relate these perceptions to disease characteristics such as severity of fatigue, physical functioning and psychological distress. <h3>Methods</h3> 127 patients (88% female, mean age=64 years) with a rheumatic disease filled out an online survey consisting of a fatigue-specific version of the PEPPI-5, MAF, HAQII, HADS and items on importance, satisfaction and experienced roles in fatigue-related communication. Data were analyzed with correlational and hierarchical regression analyses. <h3>Results</h3> Only 10% of patients evaluated fatigue-related communication as (rather) not important, 45% were satisfied with the actual communication and 77% reported that the patient had to take the initiative for fatigue-related communication. Mean score on perceived efficacy regarding fatigue-related communication (16.15, SD=4.25) was lower than those in previous studies on perceived self-efficacy in communication in general. Multivariate analyses revealed depressive symptoms as the main correlate of perceived efficacy in fatigue-related communication. <h3>Conclusions</h3> Fatigue-related communication emerged as an important topic from the patient perspective. However, satisfaction with and perceived self-efficacy in fatigue-related communication are lower compared to general patient-physician communication in chronic diseases. Possible explanations for this difference will be discussed. <h3>References</h3> ten Klooster, P. M., Oostveen, J. C., Zandbelt, L. C., Taal, E., Drossaert, C. H., Harmsen, E. J., et al. (2012). Further Validation of the 5-Item Perceived Efficacy in Patient-Physician Interactions (PEPPI-5) Scale in Patients With Osteoarthritis. Journal of Patient Education and Counseling, 125-130. <h3>Disclosure of Interest</h3> None declared
Comparison of two five-year follow-up studies: 1948 to 1952 and 1967 to 1972
Authors: J S Bockoven, H C Solomon
Journal: American Journal of Psychiatry (1975)

Results of a 5-year follow-up of 100 randomly selected patients committed to a community-oriented mental hospital in 1947 are compared with those of a 5-year follow-up of 100 randomly selected patients admitted to a community-based mental health center in 1967. The data show that both programs were successful in kepping patients with historis of long-standing mental illness in the community, even thought the 1947 group did not receive any modern psychotropic medication. One uoexpected finding of the comparison is the suggestion that these drugs might not be indispensable; in fact, they might actually prolong the social dependency of some discharged patients.
Diagnosis in Oncology. Leukemia cutis.
Authors: W C Hahn, D Jones, P Leavitt, J Garber, R Stone, A T Skarin
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.5.2170 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9164232 Diagnosis in Oncology. Leukemia cutis. W C HahnxW C HahnSearch for articles by this author , D JonesxD JonesSearch for articles by this author , P LeavittxP LeavittSearch for articles by this author , J GarberxJ GarberSearch for articles by this author , R StonexR StoneSearch for articles by this author , A T SkarinxA T SkarinSearch for articles by this author Show More Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston. MA, USA. https://doi.org/10.1200/JCO.1997.15.5.2170 PDF "Diagnosis in Oncology. Leukemia cutis.." Journal of Clinical Oncology, 15(5), pp. 2170–2171© 1997 by American Society of Clinical Oncology
The British Society of Gastroenterology
Authors: A Marten, E Elias, J A Summerfield, J Scott, S Sherlock
Journal: Gut (1976)

NW3) Pancreatic juice has been collected from within the pancreatic duct after i.v.secretin at ERCP and its trypsin inhibitory activity, total trypsinogen content, trypsin and protein concentration measured.Patients included 17 with a normal pancreas (11 non-alcoholic [control group]; 6 alcoholic), 9 with chronic pancreatitis (7 alcoholic, 2 non-alcoholic), 5 with choledocholithiasis and 6 with recent acute pancreatitis.Activation of trypsinogen was significantly increased in choledocholithiasis (p < 0-025), in all alcoholics (p < 0 05) and in chronic pancreatitis (p < 0-025).The ratio of trypsin inhibitor to trypsinogen was significantly increased in chronic alcoholic pancreatitis (p < 0 05), in acute pancrea- titis (p < 0 025), and in alcoholics without pancreatic disease (p < 0-025).No inhibitor activity was detected in 2 patients with non-alcoholic chronic pan- creatitis.The protein concentration of pancreatic juice tended to be raised in alcoholics (0 10 > p > 0 05), so that the specific activity of inhibitor was not significantly raised except after recovery from acute pancreatitis (p < 0 05).An increased ratio of trypsin inhibitor to trypsinogen in pancreatic juice is associated with alcoholism and antecedes clinically evident pancreatic disease.Deficiency of inhibitor may be associated with non-alcoholic chronic pancreatitis.Premature intraduct activation of trypsinogen occurs in alcoholism and choledocholithiasis.Increased trypsin in- hibitor secretion occurs following acute pancreatitis.Specificity of the renal amylase: creatinine clearance ratio in the diagnosis of acute pancreatitis and in detecting the incidence of pancreatitis after ERCP
Labour care of women with HIV infection
Authors: G. P Taylor, E G H. Lyall, G. Tudor-Williams, L. Regan, J. Smith, G. Chamberlain, P. Steer
Journal: BMJ (1999)

Editor—In the section on women with HIV infection in their article for the ABC of labour care, Chamberlain and Steer make several controversial and unreferenced statements.1 The key message recognises the importance of screening pregnant women for HIV infection to enable appropriate care to protect the baby; it makes no mention, however, of maternal health, preferring to highlight staff protection. In obstetrics and midwifery it would be preferable to emphasise the need to practise universal precautions to protect against any transmissible infections rather than selective practice, which puts staff and patients at risk and may stigmatise women with HIV or other infections.

The authors state that “women known to be HIV positive should be taking zidovudine and protease inhibitors during the second half of pregnancy.” The British HIV Association has written guidelines on prescribing for HIV infection in pregnancy and recommends triple antiretroviral therapy (usually zidovudine, another nucleoside analogue, and either a protease inhibitor or a non-nucleoside reverse transcription inhibitor) after the first trimester for women who, if they were not pregnant, would normally be advised to take antiretroviral therapy for their own health. For women who are asymptomatic with high CD4+ lymphocyte counts and low HIV plasma load monotherapy with zidovudine from the start of the third trimester plus caesarean section before labour begins is an option.2 Avoidance of breast feeding, zidovudine monotherapy, and elective caesarean section reduce transmission to below 2%.3,4

We are not aware of any trials of two protease inhibitors in pregnancy. In a recent study monotherapy with ritonavir reduced transmission from 19% to 9% (a similar efficacy to zidovudine) when given from week 36 of gestation. Ten of 74 women, however, stopped treatment because of side effects.5 Prescribing of antiretroviral drugs is rapidly evolving, and the management of pregnant women should be undertaken in liaison with experienced HIV physicians. The safety of antiretroviral therapy in pregnancy remains unproved, and all mother-infant pairs should be reported to the schemes set up by the Royal College of Obstetricians and Gynaecologists and the Royal College of Paediatrics and Child Health.

The protective effect of caesarean section is seen only when the section is carried out before labour, which suggests that avoiding labour is important.3,4 The 50% reduction in transmission with caesarean section documented in the European randomised mode of delivery study was with standard operating techniques.4 Any additional merits of using a staple gun to make the lower uterine segment incision are presumably speculative, and an unachievably large clinical trial would be required to show any reduction in transmission.
Diet and duodenal ulcer.
Authors: S K Sarin, A Karol
Journal: BMJ (1969)

PointersChoriocarcinoma: Follow-up of 100 patients at Charing Cross -Hospital emphasizes important role of radioimmunoassay for chorionic gonadotrophin in early diagnosis (p.733).Hypertension in Pregnancy: Blind prospective study showed increased incidence of foetomaternal bleeding before week 36 in women who developed hypertension (p.738).Vacuum Extrlction: Grave risk of serious or dangerous subaponeurotic haemorrhage in infants with low thrombotest activity born by this method (p.743).Stillbirth and Neonatal Death: Relation of birth weight and gestation period to cause of death (p.745).Peritoneal Dialysis: In-vitro study showed bacteriostatic effect of acetate added to the dialysis solution (p.749).
THU0501 Mutations in the Mthfr Gene are not Associated with Methotrexate Intolerance in Patients with Juvenile Idiopathic Arthritis
Authors: A. Scheuern, N. Fischer, J.-P. Haas, B. Hugle
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Methotrexate (MTX) is the drug used most frequently in the therapy of juvenile idiopathic arthritis (JIA). However, long-term treatment in children frequently leads to intolerance, with marked revulsion and refusal of treatment. Mutations in the gene for methylenetetrahydrofolate reductase (MTHFR) can lead to increased toxicity of MTX and could possibly represent an initial stimulus for this conditioned response. <h3>Objectives</h3> The objective of this study was to investigate the relation of common mutations in the MTHFR gene and occurrence of MTX intolerance in pediatric patients with juvenile idiopathic arthritis treated with MTX. <h3>Methods</h3> Consecutive patients admitted to the German Center for Pediatric and Adolescent Rheumatology from October 2012 until April 2014 included in this study. Inclusion criteria were 1) diagnosis of JIA and 2) treatment with MTX for at least 3 months prior to inclusion. Exclusion criteria were other diseases leading to nausea and/or abdominal complaints, and concomitant medications possibly inducing nausea (excepting biologics and non-steroidal anti-inflammatory drugs). Intolerance to MTX was determined using the validated Methotrexate Intolerance Severity Score (MISS) questionnaire; presence of MTX intolerance was assumed for MISS values of ≥6. Presence of the two most common mutations in the MTHFR gene (C677T and A1298C) was tested using a polymerase chain reaction assay, as described previously. Results were analyzed using descriptive statistics and chi square testing. <h3>Results</h3> 114 patients were included (71% female, age at inclusion (median) 12.6 years, disease duration (median) 4.1 years). Of those, 49 (43%) showed MTX intolerance. 42% of patients were heterozygous, and 7% homozygous for the C677T mutation of the MTHFR gene, 45% of patients were heterozygous, and 12% homozygous for the A1298C mutation; both are comparable to published allele frequencies. Compared to the homozygous wild type, MTX intolerance was not found significantly more frequent in patients with hetero- and homozygous (p=1.000) or homozygous (p=0.125) C677T mutations, nor in patients with hetero- and homozygous (p=0.775) or homozygous (p=0.444) A1298C mutations. Compound heterozygous mutations for C677T and A1298C were also not found significantly more frequently in patients with MTX intolerance (p=0.809). <h3>Conclusions</h3> Mutations in the MTHFR gene are not found significantly more frequently in JIA patients with intolerance to MTX. Toxicity associated with the MTHFR gene does not seem to be causally related to the development of MTX intolerance. <h3>Acknowledgements</h3> This study was supported by the "Stiftung Hilfe für das rheumakranke Kind e.V." <h3>Disclosure of Interest</h3> None declared
SAT0134 Vitamin D and its Relationship with Clinical and Laboratory Parameters in Patients with Rheumatoid Arthritis
Authors: S. Talbi, N. Aradoini, K. Salia, F.E. Abourazzak, T. Harzy
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> 25 (OH) Vitamin D deficiency is reported to be common in patients with rheumatoid arthritis (RA). It has been demonstrated in the Women9s Iowa Health Study with data from 29,368 women that vitamin D intake was inversely associated with the risk of rheumatoid arthritis. This deficiency is also reported to be associated with disease activity and physical disability in patients with RA.(1-3) <h3>Objectives</h3> To examine the prevalence of vitamin D insufficiency in patients with rheumatoid arthritis (RA) and its association with disease activity, severity and physical disability. <h3>Methods</h3> We included patients with rheumatoid arthritis in department of rheumatology of Hassan II University Hospital, Fez, Morocco. Patients suffering from liver and kidney insufficiency and those administered Vitamin D in the previous 12 months have been excluded. Statistical analysis was done using SPSS v 18. A bivariate analysis and a logistic regression were used to identify factors associated with vitamin D deficiency. <h3>Results</h3> One hundred seventy patients were included with a mean age of 50±12.1 [17-83] years and a female predominance (88.1%). All of our patients had hypovitaminosis D. The prevalence of 25(OH)-D insufficiency and deficiency was 64.5% and 35.5% successively. In unadjusted analysis, vitamin D concentration was inversely associated with pain visual analog scale VAS score (p&lt;0.001), asthenia VAS (p&lt;0.001),morning stiffness (p=0.03),number of Tender joints (p=0.004), number of Swollen joints (p&lt;0.001),inflammatory markers (p=0,012), Disease Activity Score (p=0.009), physical disability using Health Assessment Questionnaire (HAQ) (p=0.001), and severity of the disease (p&lt;0.001). After logistic regression persisted association with female sex (OR =4.3, CI = [0.94 to 20.976], p=0.05), asthenia VAS (OR =1.029, CI = [1.011 to 1.046], p=0.001), and with the severity of the disease (OR =2.910, CI = [1.314-6.441], p=0.008). <h3>Conclusions</h3> The vitamin D deficiency is common in our patients with RA. This deficiency is associated with female sex, severe asthenia and the severity of the disease. <h3>References</h3> Merlino LA, Curtis J, Mikuls TR, CerhanJR, Criswell LA, Saag KW (2004) Iowa Women9s Health Study Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women9s Health Study. Arthritis Rheum 50:72–77. Craig SM, Yu F, Curtis JR, Alarcon GS, Conn DL, Jonas B, Callahan LF, Smith EA, Moreland LW, Bridges SL Jr, Mikuls TR (2010) Vitamin D status and its associations with disease activity and severity in African Americans with recent-onset rheumatoid arthritis. J Rheumatol37:275–281. Haque UJ, Bartlett SJ (2010) Relationships among vitamin D, disease activity, pain and disability in rheumatoid arthritis. Clin Exp Rheumatol 28:745–747. <h3>Disclosure of Interest</h3> None declared
Coronary Collateral Circulation
Authors: Turgay Celik, Murat Celik, Atila Iyisoy
Journal: New England Journal of Medicine (1971)

There is a circulatory network in the heart consisting of multiple small-diameter vascular structures between the coronary arteries, connecting the coronary arteries to each other. These vascular structures which are the precursor of coronary collateral circulation are not visible in those having normal coronary arteries or mild-to-moderate coronary artery occlusions because they are too small in diameter to be seen on coronary angiograms and also have minimal blood flow. They have been observed only in postmortem studies. The sensitivity of tissues to ischemia is important as well as the extent and severity of atherosclerosis. The presence of well-developed coronary collateral circulation renders the myocardial tissue more resistant to ischemia and the patients less symptomatic. Considering the fact that coronary collateral circulation develops in response to severe coronary artery disease, it remains unknown why there are major differences among patients with the same degree of coronary artery disease and which factors are responsible for these differences.
Screening for Syphilis
Authors: Jill Jin
Journal: JAMA (2016)

US Preventive Services Task Force (USPSTF); Kirsten Bibbins-Domingo, PhD, MD, MAS; David C. Grossman, MD, MPH; Susan J. Curry, PhD; Karina W. Davidson, PhD, MASc; John W. Epling Jr, MD, MSEd; Francisco A. R. García, MD, MPH; Matthew W. Gillman, MD, SM; Diane M. Harper, MD, MPH, MS; Alex R. Kemper, MD, MPH, MS; Alex H. Krist, MD, MPH; Ann E. Kurth, PhD, RN, MSN, MPH; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; William R. Phillips, MD, MPH; Maureen G. Phipps, MD, MPH; Michael P. Pignone, MD, MPH
Novel Chimeric Transcripts Involving PAX5 in B-Cell Precursor ALL
Authors: Grazia Fazio, Clelia Tiziana Storlazzi, Marco Severgnini, Valeria Cazzaniga, Luciana Impera, Giulia Daniele, Ilaria Iacobucci, Marta Galbiati, Anna Leszl, Silvia Bungaro, Ingrid Cifola, Gianluca De Bellis, Giovanni Martinelli, Giuseppe Basso, Andrea Biondi, Giovanni Cazzaniga
Journal: Blood (2013)
Origin of the House Dust Allergen
Authors: R HALE, L P CAWLEY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intensive Treatment and Severe Hypoglycemia Among Adults With Type 2 Diabetes
Authors: Rozalina G. McCoy, Kasia J. Lipska, Xiaoxi Yao, Joseph S. Ross, Victor M. Montori, Nilay D. Shah
Journal: JAMA Internal Medicine (2016)

Intensive glucose-lowering treatment among patients with non-insulin-requiring type 2 diabetes may increase the risk of hypoglycemia.
AB0728 Serum Osteopontin and Vitronectin Levels in Systemic Sclerosis
Authors: B. Gundogdu, S. Yolbas, A. Yildirim, S. Aydin, S.S. Koca
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteopontin (OPN) a member of specialized matricellular protein has pro-inflammatory and pro-fibrotic effects and binds integrin such as αvβ1 and αvβ3. Vitronectin (VTN), one of the integrin αvβ3 ligands, is a multifunctional glycoprotein that is present in blood and in the extracellular matrix. Decreased levels of VTN have been reported in patients with meningococcal disease, rheumatoid arthritis and Behçet9s disease. <h3>Objectives</h3> The aim of the present study was to evaluate serum OPN and VTN level in systemic sclerosis (SSc) and systemic lupus erythematosus (SLE). <h3>Methods</h3> Eighty-six patients with SSc, 46 patients with SLE, and 38 healthy controls (HC) were enrolled in the study. The disease activity and severity scores in SSc group were determined by modified Rodnan skin score, Valentini activity index, Medsger disease severity index, and United Kingdom function score. In addition to routine laboratory parameters, OPN, VTN, interleukin-6, and transforming growth factor (TGF)-β levels were analyzed. <h3>Results</h3> Serum OPN levels were higher in SSc and SLE groups compared to HC group (Table and Figure). However, OPN levels in SSc group were not associated with disease activity and severity scores (p&gt;0.05). In addition, it was not correlated with SSc specific laboratory parameters, and capilleroscopic findings. On the other hand, serum VTN level was lower in the SSc group than in SLE and HC groups, while its level was similar in the SLE and HC groups (Table). Its level was negatively correlated with modified Rodnan skin score, visual analogue scales (physician and patient), lung-Medsger and heart-Medsger scores (r=-0.256, p=0.016, r=-0.450, p&lt;0.001; r=-0.321, p=0.003; r=-0.319, p=0.003 and r=-0.245, p=0.023, respectively). <h3>Conclusions</h3> OPN levels are increased in SSc and SLE. These results may suggest that OPN has not a specific role on fibrosis in SSc and that OPN level may be increases due to inflammatory process. On the other hand, serum VTN level decreases in SSc in contrast to SLE and it is negatively correlated with modified Rodnan skin score. Therefore, it may be concluded that VTN has anti-fibrotic action or the one cause of decreased serum VTN level in SSc may be the accumulation in fibrotic area. <h3>Disclosure of Interest</h3> None declared