tbuckley/cabot-search huggingface dataset:
Immunosuppression By Mesenchymal Stromal Cells Derived from Human Induced Pluripotent Stem Cells : Evaluation in an aGVHD Model
Authors: Clemence Roux, Gaelle Saviane, Gihen Dhib, Jonathan Pini, Pierre-Simon Rohrlich, Nourhene Belaid, Abdel Wakkach, Claudine Blin, Matthieu Rouleau
Journal: Blood (2014)
THU0603 Performance of The 2013 American College of Rheumatology/european League against Rheumatism Systemic Sclerosis Classification Criteria
Authors: A.M. Gheorghiu, R. Dobrota, T. Predescu, L. Grigorescu, A. Soare, M. Gorga, R. Ionitescu, R. Jurcut, S. Magda, T. Constantinescu, R. Sfrenţ-Cornăţeanu, M. Bojinca, V. Stoica, C. Mihai
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic sclerosis (ScS) is a polymorphic autoimmune disease, with increased morbidity and mortality, often diagnosed in advanced stages. The recently published 2013 American College Of Rheumatology/European League Against Rheumatism (ACR/EULAR) classification criteria for SSc were developed to increase the identification of early/mild SSc patients. <h3>Objectives</h3> To compare the sensitivity and specificity of the 2013 ACR/EULAR criteria with 1980 ACR criteria in a single-centre cohort of patients with SSc, diagnosed according to expert oppinion. <h3>Methods</h3> Data of SSc patients evaluated in our EUSTAR centre between 2004–2015 have been retrospectively analyzed. The control cohort included patients with Raynaud9s phenomenon of other ethiology than SSc, evaluated between 2009–2015. The sensitivity and specificity of the 2013 ACR/EULAR and 1980 ACR criteria were tested using the McNemar test for correlated proportions. <h3>Results</h3> One hundred and fifty one patients with SSc (90.1% women, mean±SD age 58.4±13.2 years) and 65 controls (87.7% women, mean±SD age 43.7±14.6 years) were included. The sensitivity of the 2013 ACR/EULAR and 1980 ACR criteria were 94.7% and 84.4%, respectively (p&lt;0.001). The specificity of the 2013 ACR/EULAR and 1980 ACR criteria were 86.2% and 96.9%, respectively (p=0.01). Patients missclassified according to the new 2013 ACR/EULAR criteria were 17, whereas according to the old 1980 ACR criteria were 32. The sensitivity of the 2013ACR/EULAR was significantly better than the 1980 ACR criteria in the limited cutaneous SSc patients (93.1 vs. 82.2%, p&lt;0.001). <h3>Conclusions</h3> The 2013 ACR/EULAR criteria have a better sensitivity and missclassify fewer patients than the 1980 ACR criteria. Their excelent performance is close to the gold standard of diagnosis in SSc (expert opinion). <h3>Acknowledgement</h3> <sup>*</sup>This abstract was realized as part of the “Development of a computer-based nailfold videocapillaroscopy (NVC) system for longitudinal evaluation of patients with systemic sclerosis” (QUANTICAP) project, financed by the UEFIS-CDI PN-II-PT-PCCA-2013–4-1589 grant. <h3>Disclosure of Interest</h3> None declared
Antagonism of P2y12 Receptor Results in Severe Impairment of Serum Thromboxane Levels. Can We Manage Patients without Combination Therapy with Aspirin?
Authors: Kamala Bhavaraju, Alexander Georgakis, Jianguo Jin, Yoshiaki Tomiyama, Alan T. Nurden, Paquita Nurden, Satya P. Kunapuli
Journal: Blood (2009)
Discussion of Reports on Renoprival Hypertension
Journal: Circulation (1958)

It was pointed out that some of the confusion in this field resulted from failure to define the term "hypertension." A simple rise in blood pressure was not hypertensive disease and should not be referred to as "hypertension" according to Dr. Grollman. It was stated that all hypertension is renal in origin, but due to a defect in the function rather than in the circulation of the kidney (Dr. Grollman). In both renal and renoprival hypertension there is lack of the normal renal protective mechanism, i.e., the kidneys fail to excrete some pressor substance (Dr. Handler). This protective action of the kidneys may be metabolic rather than excretory, and both renal and renoprival hypertension may be due to the lack of renal catabolism of pressor materials which may be of extrarenal as well as of renal origin (Dr. Rodbard and others).
Randomised Comparison of the Stanford V (SV) Regimen and ABVD in the Treatment of Advanced Hodgkin Lymphoma (HL): Results from a UK NCRI Lymphoma Group Study, ISRCTN 64141244
Authors: Peter W.M. Johnson, Alan Horwich, Andrew Jack, Graham Mead, Barry Hancock, Paul Smith, Wendi Qian, Philippa Patrick, Andrew Pettitt, David Cunningham, Peter Hoskin
Journal: Blood (2008)
Disruption of Mammalian Target of Rapamycin Complex 1 in Macrophages Decreases Chemokine Gene Expression and Atherosclerosis
Authors: Ding Ai, Hongfeng Jiang, Marit Westerterp, Andrew J. Murphy, Mi Wang, Anjali Ganda, Sandra Abramowicz, Carrie Welch, Felicidad Almazan, Yi Zhu, Yury I. Miller, Alan R. Tall
Journal: Circulation Research (2014)

The mammalian target of rapamycin complex 1 inhibitor, rapamycin, has been shown to decrease atherosclerosis, even while increasing plasma low-density lipoprotein levels. This suggests an antiatherogenic effect possibly mediated by the modulation of inflammatory responses in atherosclerotic plaques.Our aim was to assess the role of macrophage mammalian target of rapamycin complex 1 in atherogenesis.We transplanted bone marrow from mice in which a key mammalian target of rapamycin complex 1 adaptor, regulatory-associated protein of mTOR, was deleted in macrophages by Cre/loxP recombination (Mac-Rap(KO) mice) into Ldlr(-/-) mice and then fed them the Western-type diet. Atherosclerotic lesions from Mac-Rap(KO) mice showed decreased infiltration of macrophages, lesion size, and chemokine gene expression compared with control mice. Treatment of macrophages with minimally modified low-density lipoprotein resulted in increased levels of chemokine mRNAs and signal transducer and activator of transcription (STAT) 3 phosphorylation; these effects were reduced in Mac-Rap(KO) macrophages. Although wild-type and Mac-Rap(KO) macrophages showed similar STAT3 phosphorylation on Tyr705, Mac-Rap(KO) macrophages showed decreased STAT3Ser727 phosphorylation in response to minimally modified low-density lipoprotein treatment and decreased Ccl2 promoter binding of STAT3.The results demonstrate cross-talk between nutritionally induced mammalian target of rapamycin complex 1 signaling and minimally modified low-density lipoprotein-mediated inflammatory signaling via combinatorial phosphorylation of STAT3 in macrophages, leading to increased STAT3 activity on the chemokine (C-C motif) ligand 2 (monocyte chemoattractant protein 1) promoter with proatherogenic consequences.
Increased Immunohistochemical CD138 Expression in Waldenström's Macroglobulinemia (WM) in Comparison with Splenic Marginal Zone Lymphoma (SMZL).
Authors: Tatiana K Tzenou, G.A. Pangalis, Georgia Levidou, Christina Kalpadakis, Spyros Siakavellas, Dimitrios Maltezas, Efstathios Koulieris, Maria Dimou, Vasiliki Bartzi, Georgios Georgiou, Theodoros P. Vassilakopoulos, Maria K. Angelopoulou, Styliani Kokkoris, Penelope Korkolopoulou, Athina Androulaki, Eystathios Patsouris, Panayiotis Panayiotidis, Marie-Christine Kyrtsonis
Journal: Blood (2009)
Putting the Wnt up colon cancer
Authors: Lukas JAC Hawinkels, James CH Hardwick
Journal: Gut (2016)

If there is one cancer signalling pathway that Gut readers should be comfortable with, it is the Wnt pathway. Central to this pathway is the adenomatous polyposis coli ( APC ) gene responsible for familial adenomatous polyposis. Identification of the APC gene in 1991 heralded the start of an ongoing period of exponential growth in our understanding of the molecular basis of cancer, particularly of the large bowel. Clinicians can perhaps be forgiven for finding the ever-expanding list of genes and interacting pathways with their inaccessible names and acronyms daunting. For many, the paper in this issue by Elvira Bakker and coworkers at the Netherlands Cancer Institute revealing the detailed role of RSPO3 in colorectal carcinogenesis may only serve to widen the expanding clinician–researcher divide. However, those brave enough to dive deeper into this paper will be rewarded with an insight into the current state of the art of molecular research into colorectal cancer with an intriguing mix of confirmation of what we thought we knew and findings that challenge previous assumptions.

R-spondin 3 (RSPO3) is a secreted protein that acts to potentiate Wnt signalling. RSPOs first attracted attention as being specific ligands of the LGR5 (leucine-rich repeat-containing G-protein-coupled receptor …
PTU-003 Video: Insertion and Removal of an Ileocolonic Stent in a Complex Crohn’s Stricture
Authors: A Cole, R Singh
Journal: Gut (2016)

<h3>Introduction</h3> Crohn’s disease often causes stricturing to occur at surgical anastomoses. This may be treated by further surgery or balloon dilatation. This often requires repeated procedures because of the elastic recoil of tissues and restenosis. More recently commercially available removeable stents have been introduced onto the market. We present a video of the successful use and subsequent removal of an entero-colonic stent to treat a complex recurrent post surgical stenosis in a patient with Crohns disease. <h3>Methods</h3> Xray still and Video images are presented of enterocoloic stent insertion and subsequent removal after two weeks in a patient who had had 4 previous surgeries and had a double stricture in the neoterminal ileum. A 9 cm Diagamed Removeable covered Ileocolonic stent was used. <h3>Results</h3> See Video, Successful placement of covered TTS self expanding stent across double neoterminal ileal stricture and TI and removal. The patient at subsequent follow up reported a dramatic improvement in their previous symptoms and gained weight rapidly. <h3>Conclusion</h3> The use of removeable through the scope self expanding metal stents is now a real option for treating Crohns patients with anastomotic strictures as is illustrated by this video. <h3>Disclosure of Interest</h3> None Declared
Improvement in Right Ventricular Function Following 1 Year of Deferasirox Therapy in Patients with β-Thalassemia.
Authors: Gillian Smith, Dudley J. Pennell, John B. Porter, M. Domenica Cappellini, Lee Lee Chan, Amal El-Beshlawy, Yesim Aydinok, Hishamshah Ibrahim, Chi-Kong Lee, Vip Viprakasit, Mohsen Saleh Elalfy, Antonis Kattamis, Dany Habr, Gabor Domokos, Abdel Hmissi, Ali Taher
Journal: Blood (2009)
Potential Use of Jak2 Inhibitors to Limit Ineffective Erythropoiesis and Reverse Splenomegaly in β-Thalassemia.
Authors: Luca Melchiori, Ella Guy, Ilaria Libani, Raffaella Schirò, Pedro Ramos, Laura Breda, Amy Chadburn, Yi-Fang Liu, Maria De Sousa, Eliezer Rachmilewitz, Patricia J Giardina, Robert W Grady, Stefano Rivella
Journal: Blood (2008)
Efficacy of Eculizumab in a Plasmatherapy-Dependent Patient with Atypical Hemolytic Uremic Syndrome with C3 Mutation Following Plasmatherapy Withdrawal
Authors: Valerie Chatelet, Veronique Fremeaux-Bacchi, Maxence Ficheux, Thierry Lobbedez, Bruno Hurault-Deligny
Journal: Blood (2008)
FRI0108 Rheumatoid Arthritis Is Associated with Increased Rate of Malignancy: A Cross-Sectional Analysis of 69755 Patients
Authors: S. Tiosano, G. Segal, A. Dagan, D. Comaneshter, A.D. Cohen, H. Amital
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a common autoimmune disease, which carries a wide variety of comorbidities. The risk of developing malignancy amongst RA patients is of increased both due to the constant inflammatory activity (1) and disease therapies. <h3>Objectives</h3> To evaluate the association between RA and malignancies. <h3>Methods</h3> In this cross-sectional population based study, data were collected from Israel9s largest HMO database, comprising over 4 million patients. Study sample included all RA patients (n=11,782) and sex and age matched controls (n=57,973), total of 69755 patients. Medical records were scanned for anthropometric measurements and diagnosis of malignancy. Logistic regression was used to adjust for age, gender, BMI and socioeconomic status. <h3>Results</h3> The total malignancy rate was higher among RA patients comparing to controls (21.4% vs. 11.2%, respectively; p&lt;0.001). In multivariate analysis, Hodgkin9s and non-Hodgkin9s lymphoma, multiple myeloma, sarcomas and malignancies of thyroid and cervix were found to be independently associated with RA. Following multivariate analysis lung carcinoma were not found to be independently associated with RA. <h3>Conclusions</h3> RA is independently associated with both hematological and solid malignancies. Appropriate measures for screening for malignancies amongst this patient population should be assessed and implemented. <h3>References</h3> Baecklund E, Iliadou A, Askling J, Ekbom A, Backlin C, Granath F, et al. Association of chronic inflammation, not its treatment, with increased lymphoma risk in rheumatoid arthritis. Arthritis Rheum. 2006 Mar;54(3):692–701. <h3>Disclosure of Interest</h3> None declared
Hematopoietic Stem Cell Transplantation (HSCT) Using Plasma Depleted Umbilical Cord Blood (UCB) That Were Not Red Cell Depleted.
Authors: Robert Chow, Patrick Tan, Tang-Her Jaing, Joseph Rosenthal, Auayporn Nademanee, Chatchada Karanes, Michael Graham, Gretchen Eames, Lee Lee Chan, Brian Wang, Tiffany Chow, Tina Wu, Ah Moy Tan, Poh-Lin Tan, Hai-Peng Lin, David Gjertson, Lawrence Petz
Journal: Blood (2006)
P0834 : Significant drug–drug interaction between simeprevir and cyclosporine a but not tacrolimus in patients with recurrent chronic HCV infection after orthotopic liver transplantation: The saturn study
Authors: S. Ouwerkerk-Mahadevan, I. Vanwelkenhuysen, M. Peeters, M. Simonts, I. Ilsbroux, A. Simion, J. Witek
Journal: Journal of Hepatology (2015)
RCHOP Therapy Overcome Gastric Diffuse Large B Cell Lymphoma without Surgery
Authors: Yuko Mishima, Yasuhito Terui, Masahiro Yokoyama, Sakura Sakajiri, Noriko Nishimura, Kenji Nakano, Eriko Nara, Kazuhito Suzuki, Kentaro Nasu, Shunji Takahashi, Kengo Takeuchi, Kiyohiko Hatake
Journal: Blood (2010)
Dampened antiviral immunity to intravaginal exposure to RNA viral pathogens allows enhanced viral replication
Authors: Shahzada Khan, Erik M. Woodruff, Martin Trapecar, Krystal A. Fontaine, Ashley Ezaki, Timothy C. Borbet, Melanie Ott, Shomyseh Sanjabi
Journal: The Journal of Experimental Medicine (2016)

Understanding the host immune response to vaginal exposure to RNA viruses is required to combat sexual transmission of this class of pathogens. In this study, using lymphocytic choriomeningitis virus (LCMV) and Zika virus (ZIKV) in wild-type mice, we show that these viruses replicate in the vaginal mucosa with minimal induction of antiviral interferon and inflammatory response, causing dampened innate-mediated control of viral replication and a failure to mature local antigen-presenting cells (APCs). Enhancement of innate-mediated inflammation in the vaginal mucosa rescues this phenotype and completely inhibits ZIKV replication. To gain a better understanding of how this dampened innate immune activation in the lower female reproductive tract may also affect adaptive immunity, we modeled CD8 T cell responses using vaginal LCMV infection. We show that the lack of APC maturation in the vaginal mucosa leads to a delay in CD8 T cell activation in the draining lymph node and hinders the timely appearance of effector CD8 T cells in vaginal mucosa, thus further delaying viral control in this tissue. Our study demonstrates that vaginal tissue is exceptionally vulnerable to infection by RNA viruses and provides a conceptual framework for the male to female sexual transmission observed during ZIKV infection.
FRI0348 Feasibility and Validity of Patient Reported Outcome Measurement Information System (PROMIS) in Systemic Lupus Erythematosus
Authors: S. Kasturi, J.C. Burket, J. Berman, K. Kirou, A.B. Levine, L.R. Sammaritano, L.A. Mandl
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Accurate measurement of patient reported outcomes (PROs) is important in systemic lupus erythematosus (SLE), a heterogeneous disease in which similar symptoms can have disparate impact across patients. PROMIS offers dynamic computer adaptive tests (CATs) to precisely and efficiently measure PROs in a variety of relevant domains. <h3>Objectives</h3> The aims of this study were to: 1) assess the feasibility of administering PROMIS CATS serially to SLE outpatients 2) correlate PROMIS CATs with legacy PRO measures, SLE disease activity and organ damage 3) assess retest reliability of PROMIS CATs. <h3>Methods</h3> Adults meeting American College of Rheumatology SLE classification criteria were recruited from a SLE Center of Excellence. Subjects completed the Short Form-36 (SF-36), LupusQoL-US, and selected PROMIS CATs. SLE disease activity, flare, and damage were evaluated with the SELENA-SLEDAI and SLICC-ACR damage index. PROMIS domains were compared with disease activity, damage, and similar domains in legacy instruments using Spearman correlations. Retest reliability was evaluated among subjects reporting stable SLE activity at two assessments one week apart using intraclass correlation coefficients (ICC). <h3>Results</h3> Of 198 patients approached, 163 (82%) completed at least one assessment, 130 (80%) completing it remotely. 138 (85%) completed a retest. Most PROMIS domains showed moderate to strong correlations with similar domains in both legacy instruments (Figure 1). However, correlations between PROMIS and the physician global assessment, SELENA-SLEDAI, and SLICC-ACR damage index were generally weak and statistically insignificant. PROMIS CAT retest ICCs ranged from 0.74 to 0.89. <h3>Conclusions</h3> To our knowledge, these data are the first to show that PROMIS CATs can be successfully administered to a diverse cohort of SLE patients at the point of care or remotely, and are valid and reliable for many SLE relevant domains. Importantly, PROMIS scores did not correlate well with physician-derived measures. This disconnect between objective signs and symptoms and the subjective patient disease experience underscores the crucial need to integrate PROs into clinical care to ensure optimal disease management. <h3>Acknowledgement</h3> Funding for this study was provided by the Rheumatology Research Foundation Scientist Development Award. <h3>Disclosure of Interest</h3> None declared
Feasibility and Reproducibility of the NIH Consensus Criteria To Evaluate Response in Chronic Graft Versus Host Disease (cGvHD).
Authors: S. Mitchell, D. Jacobsohn, K. Thormann, E. Cowen, J. Fall-Dickson, M. Turner, M. Schubert, K. Baird, J. Bolanos-Meade, K. Boyd, L. Gerber, J.P. Guadagnini, M. Higman, M. Imanguli, L. Lawley, L. Li, O. Prachenko, B. Reeve, J. Smith, G. Vogelsang, S. Pavletic
Journal: Blood (2006)
Long-Term Complications after Splenectomy in Adult Chronic Immune Thrombocytopenia with a Minimum Follow up of 10 Years. First Results from a Single-Center Case-Control Study in 140 Patients with Primary ITP
Authors: Lan-huong Thai, Matthieu Mahevas, Françoise roudot-Thoraval, Laetitia Languille, Guillaume Dumas, Mehdi Khellaf, Philippe Bierling, Marc Michel, Bertrand Godeau
Journal: Blood (2014)
The 18F-FDG SUVmax Reduction After Two Cycles of R-CHOP Regimen Predicts Progression Free Survival of Patients with Diffuse Large B-Cell Lymphoma.
Authors: Rene-Olivier Casasnovas, Anne Laure Saverot, Alina Berriolo-Riedinger, Michel Toubeau, Emmanuelle Ferrant, Ingrid Lafon, Denis Caillot, Jean-Marc Riedinger, Alexandre Cochet, Inna Cochet, Jean-Noël Bastie, Eric Solary, Francois Brunotte
Journal: Blood (2009)
Disputing deindividuation: Why negative group behaviours derive from group norms, not group immersion
Authors: Stephen David Reicher, Russell Spears, Tom Postmes, Anna Kende
Journal: Behavioral and Brain Sciences (2016)

Strong social identity does not lead to lack of accountability and "bad" behavior in groups and crowds but rather causes group behavior to be driven by group norms. The solution to problematic group behavior is therefore not to individualize the group but rather to change group norms, as underlined by the relational dynamics widely studied in the SIDE tradition.
Evolution of Guidelines on Peanut Allergy and Peanut Introduction in Infants
Authors: Sara Anvari, Niti Y. Chokshi, Qurat ul Ain Kamili, Carla McGuire Davis
Journal: JAMA Pediatrics (2016)

The reported prevalence of peanut allergy among children in the United States has increased more than 3-fold in the last 20 years. Medical guidelines on the introduction of peanut as well as other allergenic foods have evolved with the emerging evidence that an early introduction to these foods is more beneficial than a delayed introduction. This review highlights the studies that have led to the evolving guidelines on peanut introduction in infants.The prevalence of peanut allergy has increased despite the publication of guidelines from the American Academy of Pediatrics in 2000, which recommended a delayed introduction of peanut. Since the 2000 guidelines, studies have provided evidence to support an earlier rather than delayed introduction. As a result, the American Academy of Pediatrics updated their guidelines in 2008 to promote peanut introduction during infancy. Current evidence continues to support the benefits of an earlier rather than delayed introduction.Over the years, guidelines on the introduction of peanut have evolved, and recent literature suggests that an earlier rather than delayed introduction is beneficial to prevent peanut allergies in infants.
The Silent World of Doctor and Patient
Authors: S. J. Reiser
Journal: JAMA (2003)

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Comparative effectiveness and safety of three different basal insulins in patients with type 2 diabetes in a real world setting (ORBIT): a multicentre, prospective, registry study
Authors: Linong Ji, Puhong Zhang, Dongshan Zhu, Juming Lu, Xiaohui Guo, Yangfeng Wu, Xian Li, Jiachao Ji, Weiping Jia, Wenying Yang, Dajin Zou, Zhiguang Zhou, Yan Gao, Satish K Garg, Changyu Pan, Jianping Weng, Sanjoy K Paul
Journal: The Lancet Diabetes & Endocrinology (2016)
Spectral Karyotyping (SKY) ANALYSIS APPLIED to CHRONIC LYMPHOCYTIC LEUKEMIA CELLS Immunostimulated with the COMBINATION DSP30/IL-2.
Authors: Fabio Morato Oliveira, Daniel Mazza Matos, Lorena Lobo Figueiredo-Pontes, Belinda Simoes, Eduardo M. Rego, Roberto P Falcao
Journal: Blood (2009)