tbuckley/cabot-search huggingface dataset:
Case 15-1984
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Kenneth A. Arndt, Terence J. Harrist
Journal: New England Journal of Medicine (1984)

Presentation of CaseA 34-year-old man was admitted to the hospital because of a mass in the iris.He was well until two months earlier, when he began to have mild night sweats and sniffles. Five weeks before admission he observed a nonpruritic nodular rash, followed soon thereafter by erythema and tearing of the right eye, with photophobia. Three-and-a-half weeks before entry he came to the Eye Clinic, where examination revealed injection of the right conjunctiva, with ++ cells and flare in the anterior chamber. The left eye appeared normal. Local treatment with prednisone acetate and dexamethasone phosphate was prescribed. . . .
LG-76ANALYSIS OF PEDIATRIC CEREBELLAR GANGLIOGLIOMAS
Authors: Yoshiki Arakawa, Bin Liu, Daiki Murata, Yohei Mineharu, Masahiro Tanji, Ko-ichi Fujimoto, Nobuyuki Fukui, Yukinori Terada, Susumu Miyamoto
Journal: Neuro-Oncology (2016)
Autocrine Complement Inhibits IL10-Dependent T-cell–Mediated Antitumor Immunity to Promote Tumor Progression
Authors: Yu Wang, Sheng-Nan Sun, Qing Liu, Yang-Yang Yu, Jian Guo, Kun Wang, Bao-Cai Xing, Qing-Feng Zheng, Michael J. Campa, Edward F. Patz, Shi-You Li, You-Wen He
Journal: Cancer Discovery (2016)

In contrast to its inhibitory effects on many cells, IL10 activates CD8(+) tumor-infiltrating lymphocytes (TIL) and enhances their antitumor activity. However, CD8(+) TILs do not routinely express IL10, as autocrine complement C3 inhibits IL10 production through complement receptors C3aR and C5aR. CD8(+) TILs from C3-deficient mice, however, express IL10 and exhibit enhanced effector function. C3-deficient mice are resistant to tumor development in a T-cell- and IL10-dependent manner; human TILs expanded with IL2 plus IL10 increase the killing of primary tumors in vitro compared with IL2-treated TILs. Complement-mediated inhibition of antitumor immunity is independent of the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) immune checkpoint pathway. Our findings suggest that complement receptors C3aR and C5aR expressed on CD8(+) TILs represent a novel class of immune checkpoints that could be targeted for tumor immunotherapy. Moreover, incorporation of IL10 in the expansion of TILs and in gene-engineered T cells for adoptive cell therapy enhances their antitumor efficacy.Our data suggest novel strategies to enhance immunotherapies: a combined blockade of complement signaling by antagonists to C3aR, C5aR, and anti-PD-1 to enhance anti-PD-1 efficacy; a targeted IL10 delivery to CD8(+) TILs using anti-PD-1-IL10 or anti-CTLA4-IL10 fusion proteins; and the addition of IL10 in TIL expansion for adoptive cellular therapy. Cancer Discov; 6(9); 1022-35. ©2016 AACR.See related commentary by Peng et al., p. 953This article is highlighted in the In This Issue feature, p. 932.
CSF GABA in caregiver spouses of Alzheimer patients
Authors: N Pomara, D Deptula, M P Galloway, P A LeWitt, M Stanley
Journal: American Journal of Psychiatry (1989)

The authors studied CSF gamma-aminobutyric acid (GABA) in 14 Alzheimer patients and nine age-matched normal subjects. The five normal subjects who were wives of the demented patients had higher CSF GABA concentrations than the four normal subjects without demented spouses.
Atheroembolism
Authors: R G Pai, J T Heywood
Journal: New England Journal of Medicine (1995)

Figure 1. Lesions typical of atheroembolism are apparent on the feet (Panel A) of a 65-year-old man who had undergone left heart catheterization through the femoral approach four weeks earlier. Nonoliguric renal failure developed (serum creatinine, 5.5 mg per deciliter [490 μmol per liter]), and livedo reticularis and cutaneous infarcts were present on both feet, with preserved distal pulses. A transesophageal echocardiogram of the descending thoracic aorta showed multiple complex, pedunculated, mobile, protruding lesions presumed to be atheromas (arrows in Panel B), the probable source of embolism.
Zanamivir-resistant influenza viruses with Q136K or Q136R neuraminidase residue mutations can arise during MDCK cell culture creating challenges for antiviral susceptibility monitoring
Authors: Karen Little, Sook-Kwan Leang, Jeff Butler, Chantal Baas, Bruce Harrower, Jenny Mosse, Ian G Barr, Aeron C Hurt
Journal: Eurosurveillance (2015)

Surveillance of circulating influenza strains for antiviral susceptibility is important to ensure patient treatment guidelines remain appropriate. Influenza A(H3N2) and A(H1N1)pdm09 virus isolates containing mutations at the Q136 residue of the neuraminidase (NA) that conferred reduced susceptibility to the NA inhibitor (NAI) zanamivir were detected during antiviral susceptibility monitoring. Interestingly, the mutations were not detectable in the viruses from respective clinical specimens, only in the cultured isolates. We showed that variant viruses containing the Q136K and Q136R NA mutations were preferentially selected in Madin-Darby canine kidney epithelial (MDCK) cells, but were less well supported in MDCK-SIAT1 cells and embryonated eggs. The effect of Q136K, Q136R, Q136H and Q136L substitutions in NA subtypes N1 and N2 on NAI susceptibility and in vitro viral fitness was assessed. This study highlights the challenges that cell culture derived mutations can pose to the NAI susceptibility analysis and interpretation and reaffirms the need to sequence viruses from respective clinical specimens to avoid misdiagnosis. However, we also demonstrate that NA mutations at residue Q136 can confer reduced zanamivir, peramivir or laninamivir susceptibility, and therefore close monitoring of viruses for mutations at this site from patients being treated with these antivirals is important.
Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments
Authors: Simon L. Schuster, Felix J. Segerer, Florian A. Gegenfurtner, Kerstin Kick, Christoph Schreiber, Max Albert, Angelika M. Vollmar, Joachim O. Rädler, Stefan Zahler
Journal: Biomaterials (2016)
Wasting Away
Authors: Ole-Petter R. Hamnvik, Carolyn B. Becker, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2014)

A 40-year-old woman presented to the emergency department with pain, weakness, and poor oral intake. In the 3 months preceding presentation, she had noted the gradual onset of bilateral diffuse flank pain that progressed to affect her lower back, abdomen, and both arms and legs.
Inpatient and outpatient patterns of psychotropic drug prescribing by nonpsychiatrist physicians
Authors: D Raft, J Davidson, T C Toomey, R F Spencer, B F Lewis
Journal: American Journal of Psychiatry (1975)

The authors found that among 228 general hospital patients, minor tranquilizers were prescribed most often and with the least justification and that major tranquilizers were prescribed sparingly and by and large judiciously. Antidepressants were given less often than would be justified by the incidence of depressive illness among these patients. Nonrecognition of depression in patients with somatic complaints and autonomic signs of depression contributed to this lack of treatment.
Predictive and prognostic value of early pet evaluation on disease progression of advanced non-small cell lung cancer
Authors: G.L. Banna, G. Anile, G. Russo, P. Vigneri, M. Castaing, M. Nicolosi, S. Strano, F. Fraggetta, F. Marletta, S. Gieri, S. Spina, G. Scandurra, S. Calì, H. Lipari, M. Ippolito
Journal: Annals of Oncology (2015)
RA-11ADDED VALUE OF 1-H MAGNETIC RESONANCE SPECTROSCOPY FOR THE DIAGNOSIS OF PAEDIATRIC BRAIN LESIONS IN CLINICAL PRACTICE
Authors: Karen Manias, Martin English, Daniel Ford, Simprandip Gill, Lesley MacPherson, Ina Nicklaus-Wollenteit, Desidario Rodrigues, Andrew Peet
Journal: Neuro-Oncology (2016)
Case 7-1989
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Frederick A. Jakobiec, Judith A. Ferry
Journal: New England Journal of Medicine (1989)

Presentation of CaseA 28-year-old woman was admitted to the hospital because of right exophthalmos and ptosis after radiation treatment for Hodgkin's disease.She was well until 41 months earlier, when she noticed a lump on the right side of her neck, followed by several bouts of mild dyspnea, with a chronic cough and episodes of choking on solid foods. The patient consumed little alcohol and did not smoke. There was no history of fever, chills, sweats, anorexia, weight loss, pruritus, previous radiation treatment to the neck or elsewhere, or symptoms of hypermetabolism or hypometabolism. Six months later she was . . .
Effect of Epsilonaminocaproic Acid on the Turnover of Labelled Fibrinogen in Rabbits
Authors: J. Gajewski, B. Alexander
Journal: Circulation Research (1963)

The concept that coagulation proceeds constantly in vivo with fibrinolytie removal of the end product, fibrin, is still to be validated. 1his hypothesis, underlying the v. Rokitansky-Duguid-Astrup theory of the pathogenesis of atherosclerosis, 2 ^ postulates that fibrin polymers arc constantly deposited on the vascular wall as a consequence of clotting, and then promptly lysed by a "preventive" fibrinolytie enzyme system.The disturbance in the normal physiology of the coagulation balance could be an important factor in hemorrhagic phenomena on the one hand, or in the pathogenesis of atherosclerosis or its complications 4 ' 0> T on the other.The present communication describes an attempt to validate this concept by experi-mental^ tipping the postulated balance by means of an agent, epsilonaminoeaproic acid (EACA) which is known to block the fibrinogenolytie as well as the fibrinolytie system.Under these conditions one would expect retarded turnover of fibrinogen that was suitably labelled and administered to animals that had also received the fibrinolytic blocking agent. Methods I 131 LABELLED BOVINE FIBRINOOENArmour Fraction I from bovine plasma (60% of protein clottable with thrombin, as estimated by Kjeldahl method) was labelled with I 181 according to the technique adapted from the method of Eiaen and Keston. 8' e The final solution contained about 1% fibrinog-eii in 0.1 M phosphate buffer, pH 7.6, and approximately 50 fte of
Human Chorionic Gonadotropin Hormone Induces Indoleamine 2,3-Dioxygenase and Interleukin-10 Expression In Patients With Graft-Versus-Host-Disease
Authors: Ahmet H. Elmaagacli, Markus Ditschkowski, Nina-Kristin Steckel, Hellmut Ottinger, Uwe Hillen, Rudolf Trenschel, Dietrich Beelen, Michael Koldehoff
Journal: Blood (2013)
Political Doldrums
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1978)

Since, as someone long ago observed, the business of the press is fights and forecasts, the medical profession might easily assume that Washington rings with controversies concerning health care and related matters. There is an impressive yardage of clippings to support that impression.But the fact of the matter is that a somnolence that recalls the Eisenhower era currently envelops Washington. The big difference between now and then, however, is that the father-figure general was in harmony with his time, whereas the activist engineer incumbent simply grates the capital's power structure.Mr. Carter's problem is that there are no big . . .
IgA1 Glycosylation Is Heritable in Healthy Twins
Authors: Hannah J. Lomax-Browne, Alessia Visconti, Charles D. Pusey, H. Terence Cook, Tim D. Spector, Matthew C. Pickering, Mario Falchi
Journal: Journal of the American Society of Nephrology (2016)

IgA nephropathy (IgAN) is the most common form of primary GN and an important cause of kidney failure. Characteristically, patients with IgAN have increased serum levels of undergalactosylated IgA1 (gd-IgA1). To assess the degree to which serum gd-IgA1 levels are genetically determined in healthy individuals, we determined serum IgA and gd-IgA1 levels by ELISA in a sample of 148 healthy female twins, including 27 monozygotic and 47 dizygotic pairs. Using the classic twin model, we found the heritability of serum gd-IgA1 and IgA levels to be 80% (95% confidence interval, 66% to 89%) and 46% (95% confidence interval, 15% to 69%), respectively. These data indicate that serum gd-IgA1 levels are highly heritable. Elucidating the genetic basis of this heritability will be important in understanding the pathogenesis of IgAN.
ECT-induced EEG asymmetry and therapeutic response in melancholia: relation to treatment electrode placement
Authors: R Abrams, M A Taylor, J Volavka
Journal: American Journal of Psychiatry (1987)

Six right-unilateral and bilateral ECTs were equally effective in reducing Hamilton Rating Scale for Depression scores in 34 melancholic patients whose EEG symmetry did not change after ECT. However, a substantial therapeutic advantage was recorded for bilateral ECT in those patients whose EEG symmetry changed. Accentuation of ECT-induced EEG slowing over the right hemisphere was associated with right-unilateral ECT and a lesser treatment response, suggesting that the therapeutic advantage reported by some investigators for bilateral over right-unilateral ECT may be attributed to a poor outcome experienced by those unilateral ECT patients who developed right-sided EEG slowing.
Transplantation of Leukemia from Inbred to Noninbred Guinea Pigs2
Authors: Eli M. Nadel
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Transplantation of Leukemia from Inbred to Noninbred Guinea Pigs Get access Eli M. Nadel Eli M. Nadel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 3, September 1957, Pages 351–359, https://doi.org/10.1093/jnci/19.3.351 Published: 01 September 1957 Article history Received: 22 March 1953 Published: 01 September 1957
Social discrediting of psychiatry: the protasis of legal disfranchisement
Authors: P E Dietz
Journal: American Journal of Psychiatry (1977)

The author believes that recent legal decisions against psychiatrists (including class action suits) have their genesis in writings by sociologists and other behavioral scientists, including psychiatrists, who have examined psychiatry in the context of social structure and social processes. The discrediting of the medical model could have been accomplished using theorectical assertions and research observations that had been published before 1940, but it did not occur until the human rights movement of the 1960s. The author reviews the assertions on which the discrediting of the medical model has been based. He stresses the distinction between the testing of a theory and the discrediting of a model and observes that the recent wholesale discrediting of psychiatry has relied less on theory testing than on polemical rhetoric and unwarranted extrapolation from empirical facts.
A NEW ERA IN MEDICAL EDUCATION
Authors: M R ZAVON
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
“Cold” Spondylodiscitis on 18F-FDG PET/CT in a Patient With Myelofibrosis
Authors: Etienne Rousseau, Khun Visith Keu
Journal: Clinical Nuclear Medicine (2015)

A 74-year-old man was evaluated by bone scan for possible rib fractures, which revealed a diffuse skeletal uptake secondary to myelofibrosis and focal midthoracic uptake. Chest CT and 18F-FDG PET/CT demonstrated pathological vertebral fractures of the midthoracic spine, which appeared as a cold defect on PET comparing to intense marrow uptake related to myelofibrosis and a lung nodule with a low uptake, later biopsy-proven as non–small cell lung carcinoma (NSCLC). MRI confirmed CT findings for the spine noting also an enhanced epidural collection. Biopsies did not reveal malignant cells. Final diagnosis was spondylodiscitis and a stage I NSCLC.
Case 30-1968
Authors: Arnold N. Weinberg, Robert E. Scully
Journal: New England Journal of Medicine (1968)

Presentation of CaseA fifty-four-year-old man was admitted to the hospital because of weakness and diarrhea.He had been well until one year previously, when a radiologic examination revealed extensive infiltrates in both upper lung fields consistent with tuberculosis. On admission to a sanatorium cultures of the sputum were positive for Mycobacterium tuberculosis; isoniazid (INH), 300 mg daily, and streptomycin, 1 gm daily, were administered. Six months later he was discharged on a regimen of INH and para-aminosalicylic acid (PAS). During the eleven months before entry several cultures of the sputum were negative for M. tuberculosis, and x-ray . . .
HG-27ACUTE TOXICITY OF TEMOZOLOMIDE- VERSUS CISPLATIN-BASED RADIOCHEMOTHERAPY IN PEDIATRIC HIGH GRADE GLIOMA: COMPARATIVE ANALYSIS OF PROSPECTIVE, CONSECUTIVE, MULTICENTRIC AND MULTINATIONAL TRIALS OF THE GERMAN HIT-HGG STUDY GROUP
Authors: André O. von Bueren, Clemens Seidel, Marion Hoffmann, Sabrina Bojko, Torsten Pietsch, Monika Warmuth-Metz, Rolf-Dieter Kortmann, Christof M. Kramm
Journal: Neuro-Oncology (2016)
18F-Choline PET/CT and Prostate MRI for Staging Patients With Biochemical Relapse After Irradiation for Prostate Cancer
Authors: Laurent Quero, Laetitia Vercellino, Eric de Kerviler, Pierre Mongiat-Artus, Stephane Culine, Pascal Merlet, Vincent Ravery, Paul Meria, Francois Desgrandchamps, Christophe Hennequin
Journal: Clinical Nuclear Medicine (2015)

The aim of this study was to assess the value of combining MRI and F-fluorocholine (FCH) PET/CT for patients with a biochemical relapse (BR) after prostate radiotherapy or brachytherapy.All patients with a BR (BR definition: nadir prostate-specific antigen, +2 ng/mL) had a multiparametric MRI and FCH PET/CT if there was no clinical sign of relapse. Identification of the relapse was considered positive if both imaging techniques were concordant or in case of pathological relapse confirmation.Sixty-five consecutive patients were analyzed. Initial treatment was external beam radiation therapy (EBRT; n = 40), surgery followed by EBRT (n = 11), or brachytherapy (n = 14). Gleason score was 6 in 23 patients, 7 in 35 patients, and 8 to 10 in 7 patients. Median prostate-specific antigen value at the time of relapse was 7.6 ng/mL. Determination of relapse location was identified in 46 patients (70.7%). Relapses were only local in 24 patients (37%), nodal in 16 (24.6%), and distant in 9 (14%). In 4 cases, MRI showed a local relapse not seen by FCH PET/CT. Among the 24 patients with an isolated local relapse, 13 underwent a confirmatory biopsy and 9 were positive. At the end, only 7 patients (11%) could have a salvage local treatment: cryotherapy of the prostate in 6 cases and 1 nodal EBRT.In case of BR after radiotherapy or brachytherapy, combining MRI and FCH PET/CT could identify the site of relapse in 70% of patients. This could facilitate the selection of the patients for local salvage treatment.
Integrated Classification of Prostate Cancer Reveals a Novel Luminal Subtype with Poor Outcome
Authors: Sungyong You, Beatrice S. Knudsen, Nicholas Erho, Mohammed Alshalalfa, Mandeep Takhar, Hussam Al-deen Ashab, Elai Davicioni, R. Jeffrey Karnes, Eric A. Klein, Robert B. Den, Ashley E. Ross, Edward M. Schaeffer, Isla P. Garraway, Jayoung Kim, Michael R. Freeman
Journal: Cancer Research (2016)

Abstract Prostate cancer is a biologically heterogeneous disease with variable molecular alterations underlying cancer initiation and progression. Despite recent advances in understanding prostate cancer heterogeneity, better methods for classification of prostate cancer are still needed to improve prognostic accuracy and therapeutic outcomes. In this study, we computationally assembled a large virtual cohort (n = 1,321) of human prostate cancer transcriptome profiles from 38 distinct cohorts and, using pathway activation signatures of known relevance to prostate cancer, developed a novel classification system consisting of three distinct subtypes (named PCS1–3). We validated this subtyping scheme in 10 independent patient cohorts and 19 laboratory models of prostate cancer, including cell lines and genetically engineered mouse models. Analysis of subtype-specific gene expression patterns in independent datasets derived from luminal and basal cell models provides evidence that PCS1 and PCS2 tumors reflect luminal subtypes, while PCS3 represents a basal subtype. We show that PCS1 tumors progress more rapidly to metastatic disease in comparison with PCS2 or PCS3, including PSC1 tumors of low Gleason grade. To apply this finding clinically, we developed a 37-gene panel that accurately assigns individual tumors to one of the three PCS subtypes. This panel was also applied to circulating tumor cells (CTC) and provided evidence that PCS1 CTCs may reflect enzalutamide resistance. In summary, PCS subtyping may improve accuracy in predicting the likelihood of clinical progression and permit treatment stratification at early and late disease stages. Cancer Res; 76(17); 4948–58. ©2016 AACR.
Recombinant human granulocyte-macrophage colony-stimulating factor after chemotherapy in patients with acute myeloid leukemia at higher age or after relapse
Authors: T Buchner, W Hiddemann, M Koenigsmann, M Zuhlsdorf, B Wormann, A Boeckmann, EA Freire, G Innig, G Maschmeyer, WD Ludwig
Journal: Blood (1991)
Oncolipids?
Authors: Philip S. Schein
Journal: New England Journal of Medicine (1986)

ONE of the principal obstacles to the improvement of survival statistics among patients with cancer is the difficulty in making an early diagnosis. In particular, we are currently unable to screen large asymptomatic populations for occult primary tumors in a cost-effective manner. The value of screening with standard diagnostic procedures has been confirmed in selected instances, as in Pap-smear examinations for cervical carcinoma and mammographic evaluations for breast cancer. Conventional radiologic tests are deficient, however, in their ability to detect small internal tumor masses. The realistic limit to diagnosis is a neoplasm of 1 cm3. Such a tumor is . . .
Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise
Authors: Paula Mera, Kathrin Laue, Mathieu Ferron, Cyril Confavreux, Jianwen Wei, Marta Galán-Díez, Alain Lacampagne, Sarah J. Mitchell, Julie A. Mattison, Yun Chen, Justine Bacchetta, Pawel Szulc, Richard N. Kitsis, Rafael de Cabo, Richard A. Friedman, Christopher Torsitano, Timothy E. McGraw, Michelle Puchowicz, Irwin Kurland, Gerard Karsenty
Journal: Cell Metabolism (2016)