tbuckley/cabot-search huggingface dataset:
VIth axis for DSM-III: psychodynamic evaluation
Authors: T B Karasu, A E Skodol
Journal: American Journal of Psychiatry (1980)

DSM-III has raised questions among mental health professionals about the relationship of diagnosis to treatment. Practicing psychotherapists have been reluctant to endorse the revised classification, arguing that diagnostic discriminations needed to plan psychotherapy treatment are absent from DSM-III's multiaxial system. The clinical usefulness of a diagnostic classification is a major measure of its validity. The authors illustrate with three patients from psychotherapy practice, all with long-standing problems of depressed mood, the limits of DSM-III in planning psychotherapy treatment, and they make suggestions for the development of a treatment-oriented "axis" to complement the current multiaxial evaluation system.
Lung Tumors Produced by Intratracheal Inoculation of Polyoma Virus in Syrian Hamsters
Authors: Alan S. Rabson, William J. Branigan, Frances Y. Legallais
Journal: JNCI Journal of the National Cancer Institute (1960)

Proliferative lesions of bronchiolar and alveolar-lining cells, and tumors with histologic features of bronchiolar carcinoma, alveolar-cell carcinoma, and squamous-cell carcinoma have been produced in the lungs of hamsters inoculated intratracheally with polyoma virus. The areas of squamous-cell carcinoma appeared to arise in bronchioles and intrapulmonary bronchi; however, no evidence of origin from trachea or main bronchi was found. A transplantable squamous-cell carcinoma has been derived from one of the lung tumors and has retained squamous differentiation for four transplant generations. Attempts to isolate polyoma virus from one of the lung tumors and from the transplanted squamous-cell carcinoma have been unsuccessful. The possible significance of these findings in the search for etiologic factors in human lung cancer is discussed.
Prevailing effectiveness of the 2009 influenza A(H1N1)pdm09 vaccine during the 2010/11 season in Sweden
Authors: K Widgren, M Magnusson, P Hagstam, M Widerström, Å Örtqvist, I M Einemo, P Follin, A Lindblom, S Mäkitalo, O Wik, A Österlund, M Grünewald, I Uhnoo, A Linde
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Killing time: Treatment delay and breast cancer survival
Authors: S. Sheinfeld Gorin, J. E. Heck, B. Cheng
Journal: Journal of Clinical Oncology (2007)

6589 Introduction: Treatment delay is commonly associated with reduced breast cancer survival. Inadequate or delayed follow-up for positive findings is the most common reason for breast cancer-related litigation in the U.S. The United Kingdom has made improvements in the delivery of breast cancer services a priority for resources with the aim of reducing delays. Yet, the evidence for the association of delay and breast cancer survival is mixed. Most studies rely on small, non-representative cohorts, treatment approaches have changed over the time since the the most widely-cited review. Studies cite wide variations in delay, and some research is subject to publication or lead time bias. Aims. The purpose of this study is to examine the influence of 3-month breast cancer treatment delay on survival using a large, longitudinal, population-based dataset to provide more definitive findings. Methods: Subjects were 43,359 female Medicare enrollees age 65 and older who were diagnosed with breast cancer between 1992 and 1999 and identified by the Surveillance, Epidemiology, and End Results (SEER) program for whom treatment delay information could be obtained. Billing claims from inpatient, outpatient and provider visits were used. Mortality from breast cancer was assessed through SEER linkage with death certificates. Using propensity scores to balance the comparison groups, the association between treatment delays of three months or more and cancer survival time were analyzed using Cox proportional hazards models with gamma frailty to account for the clustering effect due to census tract. To account for known predictors of breast cancer survival, in addition to the propensity scores, we adjusted for cancer stage, comorbidity, marital status, tumor characteristics, location, detection by screening or diagnostic mammography, and the average number of health provider visits during the study period. Results: Subjects who had over a three month delay in receiving any treatment had a 34% increased risk of breast cancer death by comparison to women with delays less than three months (adjusted Hazard ratio 1.34, 1.01–1.77). Discussion: Three-month delays in accessing breast cancer treatment have a clear relationship to survival. Rapid access to treatment is recommended for all women with breast cancer. No significant financial relationships to disclose.
Don't be mis-guided when the data are silent and the editorial misses the mark.
Authors: C R Thomas, T E Williams, A T Turrisi
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.4.1631 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9552078 Don't be mis-guided when the data are silent and the editorial misses the mark. C R Thomas JrxC R Thomas JrSearch for articles by this author , T E WilliamsxT E WilliamsSearch for articles by this author , A T Turrisi 3rdxA T Turrisi 3rdSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.4.1631 PDF "Don't be mis-guided when the data are silent and the editorial misses the mark.." Journal of Clinical Oncology, 16(4), pp. 1631–1632© 1998 by American Society of Clinical Oncology
Radioiodine Uptake by Transplantable Tumors of the Thyroid Gland in C3H Mice. I. Experimental Results
Authors: S. H. Wollman, E. O. Scow, B. Wagner, H. P. Morris
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Radioiodine Uptake by Transplantable Tumors of the Thyroid Gland in C3H Mice. I. Experimental Results Get access S. H. Wollman, S. H. Wollman Search for other works by this author on: Oxford Academic PubMed Google Scholar E. O. Scow, E. O. Scow Search for other works by this author on: Oxford Academic PubMed Google Scholar B. Wagner, B. Wagner Search for other works by this author on: Oxford Academic PubMed Google Scholar H. P. Morris H. P. Morris National Cancer Institute and National Institute of Arthritis and Metabolic Diseases3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 4, February 1953, Pages 785–805, https://doi.org/10.1093/jnci/13.4.785 Published: 01 February 1953 Article history Received: 01 July 1952 Published: 01 February 1953
Soundings: Busman's holiday
Authors: Trisha Greenhalgh
Journal: BMJ (2006)

If you want a good holiday, go well beyond the range of your mobile phone network and leave your stethoscope at home. Better still, sign up for a boat trip in a tropical ocean and spend at least four hours a day under water chilling out with the fish. As all scuba diving doctors know, as soon as the boat has pulled out of port for its seven-day “reefs and wrecks” tour, the captain will ask if there are any medics on board.

The reluctant doc on a live-aboard operates in what sociologists call a “liminal zone”—a place betwixt and between, with neither the reckless abandon of the holidaymaker nor the formal mandate of the professional. Could you hack it? Try this quiz:



(1) Half the boat are upchucking and groaning in their cabins with gastroenteritis. The “fully comprehensive medical kit” advertised in the brochure is being pulled apart for antibiotics, “intestinal cleansers,” and motility inhibitors. Do you (a) deliver a pious sermon on the merits of oral rehydration therapy; (b) get on with your own dive, since they will ignore your advice anyway; or (c) sell your personal supply of ciprofloxacin to the highest bidder?


A diver has sustained a deep laceration from a coral cut. The medical kit contains stitches and a pair of gloves but no instruments or local anaesthetic. Having boiled up a pair of mechanic's pliers and someone's eyebrow tweezers, do you then (a) attempt acupuncture using a book of Chinese medicine you found on the book-swap shelf; (b) relabel the emergency oxygen cylinder “Entonox” and hope for a strong placebo effect; or (c) make creative use of the superglue which someone has brought along to repair their fins with?


Passenger A has failed to drink adequately and is now writhing with probable renal colic, unresponsive to the available analgesics. Passengers B to Q have paid a substantial sum for their trip and expect the tour company to deliver on the itinerary. Do you (a) authorise a return to shore and risk being lynched by your fellow passengers; (b) administer the only injectable analgesic available, whose name you do not recognise and whose package insert, in an unknown eastern European language, includes the word “anaphylaxis”; (c) require all passengers to hand over their personal medication in the hope that you might rustle up the ingredients for a Brompton cocktail?






Answers on the website, please.
Histochemical Characteristics of Intrasplenic Ovarian Transplants in Gonadectomized Rats&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Helen Wendler Deane, Don W. Fawcett
Journal: JNCI Journal of the National Cancer Institute (1956)

Histochemical Characteristics of Intrasplenic Ovarian Transplants in Gonadectomized Rats Get access Helen Wendler Deane, Helen Wendler Deane Department of Anatomy, Harvard Medical School, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Don W. Fawcett Don W. Fawcett Department of Anatomy, Harvard Medical School, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages 541–567, https://doi.org/10.1093/jnci/17.5.541 Published: 01 November 1956 Article history Received: 04 June 1956 Published: 01 November 1956
Quality Assurance and Psychiatric Practice: A Review
Authors: Benjamin Liptzin
Journal: American Journal of Psychiatry (1974)

Peer review in psychiatry will be difficult because of inadequate records, lack of agreement on diagnosis, the limited usefulness of psychiatric diagnosis, wide variations in criteria for hospitalization and discharge, the complex nature of the psychotherapy treatment process, and problems infitting all mental health care to the "medical model." However, the PSRO legislation has the potential to improve record keeping, to focus treatment on the reason for hospitalization, to lead to greater involvement of the family and social system in the treatment process and discharge planning, to improve continuity of care, and to stimulate medical care research in mental health.
Short cuts: What's new in the other general journals
Journal: BMJ (2006)

potentially useful for patients with poor blood pressure control who are taking three or more drugs.Using the guidelines outlined in this article and restricting the use of spironolactone to 25 mg, we have found the incidence of serious hyperkalaemia and substantial renal dysfunction to be low.By careful monitoring, however, we have also identified occasional serious cases of hyperkalaemia and stopped treatment before adverse events occurred.
Angiotensin-converting enzyme genotype and renal allograft survival.
Authors: J Beige, S Scherer, A Weber, S Engeli, G Offermann, G Opelz, A Distler, A M Sharma
Journal: Journal of the American Society of Nephrology (1997)

Increased activity of the renin-angiotensin system has been implicated in decreased, long-term survival of renal allografts. Recent studies suggest that a deletion variant of the angiotensin-converting enzyme, associated with increased humoral and tissue activity of this enzyme, is a risk factor for the development of diabetic nephropathy and the progression of IgA nephropathy. To determine whether the deletion variant of the angiotensin-converting enzyme gene influences the long-term outcome in renal transplant recipients, the relationship between donor and recipient angiotensin-converting enzyme genotype and clinical outcome were examined over a follow-up period up to 30 mo in a cohort of 269 Caucasian patients undergoing kidney transplantation between 1988 and 1993. In a subsequent case control study, the frequencies of the angiotensin-converting enzyme genotype were compared in a group of Caucasian patients with a graft survival of less than 3 yr (mean survival, 11 mo; n = 328) with the frequencies in patients with a graft survival of at least 3 yr (mean survival, 65 mo, n = 461). Neither in the cohort nor in the case control study was there a significant effect of recipient or donor angiotensin-converting enzyme genotype on transplant survival. Furthermore, the frequency of the angiotensin-converting enzyme deletion allele both in recipients and donors was similar to that reported in Caucasian controls. This study, therefore, does not support the hypothesis that the recipient or donor angiotensin-converting enzyme insertion/deletion polymorphism is an important determinant of transplant survival in Caucasian patients undergoing renal transplantation.
Feline Oncornavirus-Associated Cell Membrane Antigen. III. Antibody Titers in Cats From Leukemia Cluster Households&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: M Essex, R M Jakowski, W D Hardy, S M Cotter, P Hess, A Sliski
Journal: JNCI Journal of the National Cancer Institute (1975)

Serum samples from 182 healthy cats residing in environments known to have a natural exposure to feline leukemia virus (FeLV) were examined for the presence of antibody to the feline oncornavirus-associated cell membrane antigen. The number included 138 cats from leukemia-“cluster” households. Such cats previously showed greatly increased frequencies of FeLV infection, as determined by the virus group-specific antigen (gsa) in peripheral blood leukocytes and platelets. The geometric mean antibody titer for all 182 cats with known exposure to FeLV was 4.69, more than four times higher than the mean titer for healthy pet cats from the same geographic areas but with no known FeLV exposure. About 92% ot the cats in exposure environments were positive for FeLV gsa or feline oncornavirus-associated cell membrane antigen (FOCMA) antibody, and gsa-positive cats had lower FOCMA antibody geometric mean titers than gsanegative cats. In the exposure environments, no differences were seen for cats of different sexes, but a higher geometric mean antibody titer was observed for cats 5 years and over when compared to younger groups. These results prove that previous reports of increased incidences of leukemia in cluster households were not due to chance alone, but rather to increased infection rates of cats in the FeLV environment. Also, they suggest that horizontal transmission of FeLV is highly efficient under crowded conditions, and that most cats naturally exposed to virus elicit an active immune response.
Clinical prognostic factors in adjuvant melanoma trial.
Authors: L Nathanson
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.6.1967 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8656271 Clinical prognostic factors in adjuvant melanoma trial. L NathansonxL NathansonSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.6.1967 PDF "Clinical prognostic factors in adjuvant melanoma trial.." Journal of Clinical Oncology, 14(6), pp. 1967–1968© 1996 by American Society of Clinical Oncology
Believe it or not
Authors: Liam Farrell
Journal: BMJ (2007)

Belief is an emotional state that is not susceptible to rational persuasion, said Spinoza. And, boy, could I sing a few bars of that—although my seminal experience was not at some frenzied religious festival with people slashing themselves theatrically or falling down speaking in tongues but in the cold light of the surgical ward.

When I was a surgical intern a young man was admitted with a left upper quadrant mass. Ireland was a poor country then; advanced imaging was not available, so the diagnosis largely depended on clinical examination and was a mystery until the senior registrar arrived.

“It's an enlarged spleen,” he proclaimed, “I can feel a notch.” His certainty was such that none could gainsay him. We all had another go; sure enough, there it was clear as a day: a notch. How could we have missed it?

The news spread like wildfire around the hospital and further afield. Medical students just love their clinical signs, and they came in their thousands to palpate this wonderful notch. The senior registrar, by now rather proprietorial, would, with the touch of a showman, gently guide their hands over the patient's abdomen. They would palpate timidly, seem confused and uncertain for a long moment—but then, as they looked at the senior registrar's expectant face, their eyes would light up. “Yes, there it is, I can feel it, it's a notch, most definitely a notch, a wonderful, wonderful notch, the most wonderful notch that I have ever felt.”

It was a bandwagon: the enthusiasm was infectious and overwhelming. As with the emperor's new clothes, no one wanted to be an outsider; everyone wanted to belong, to be part of the gang. Everyone either believed they really could feel that notch or pretended they could, in case they looked stupid.

Our senior registrar's stock rose mightily, and he bestrode the wards like a colossus. The message was clear, he opined grandly to his adoring acolytes, like a fat and obnoxious Buddha: blood tests and x rays are all very well, but at the end of the day you couldn't beat good old fashioned clinical acumen.

Dawn came up like thunder on what Seamus Heaney might have termed “the fatal conclave” on the day of the laparotomy, the gallery packed with supporters. We opened up the patient and found … a big kidney and, to add insult to injury, a rather small and apologetic spleen. The senior registrar paled, the crowd sagged, detumescent with disappointment, and at the back someone started singing, “The king is in the altogether, the altogether …”
New Technique for Studying the Cytology of Gastric Aspirates in Man&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Franklin Hollander, Manfred Hess, Herbert A. Sober
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article New Technique for Studying the Cytology of Gastric Aspirates in Man Get access Franklin Hollander, Franklin Hollander Gastroenterology Research Laboratory, The Mount Sinai Hospital, New York City Search for other works by this author on: Oxford Academic PubMed Google Scholar Manfred Hess, Manfred Hess Gastroenterology Research Laboratory, The Mount Sinai Hospital, New York City Search for other works by this author on: Oxford Academic PubMed Google Scholar Herbert A. Sober Herbert A. Sober Gastroenterology Research Laboratory, The Mount Sinai Hospital, New York City Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 365–366, https://doi.org/10.1093/jnci/7.5.365 Published: 01 April 1947
Prostate Cancer Susceptibility in Men of African Ancestry at 8q24
Authors: Ying Han, Kristin A Rand, Dennis J Hazelett, Sue A Ingles, Rick A Kittles, Sara S Strom, Benjamin A Rybicki, Barbara Nemesure, William B Isaacs, Janet L Stanford, Wei Zheng, Fredrick R Schumacher, Sonja I Berndt, Zhaoming Wang, Jianfeng Xu, Nadin Rohland, David Reich, Arti Tandon, Bogdan Pasaniuc, Alex Allen, Dominique Quinque, Swapan Mallick, Dimple Notani, Michael G Rosenfeld, Ranveer Singh Jayani, Suzanne Kolb, Susan M Gapstur, Victoria L Stevens, Curtis A Pettaway, Edward D Yeboah, Yao Tettey, Richard B Biritwum, Andrew A Adjei, Evelyn Tay, Ann Truelove, Shelley Niwa, Anand P Chokkalingam, Esther M John, Adam B Murphy, Lisa B Signorello, John Carpten, M Cristina Leske, Suh-Yuh Wu, Anslem J M Hennis, Christine Neslund-Dudas, Ann W Hsing, Lisa Chu, Phyllis J Goodman, Eric A Klein, S Lilly Zheng, John S Witte, Graham Casey, Alex Lubwama, Loreall C Pooler, Xin Sheng, Gerhard A Coetzee, Michael B Cook, Stephen J Chanock, Daniel O Stram, Stephen Watya, William J Blot, David V Conti, Brian E Henderson, Christopher A Haiman
Journal: JNCI Journal of the National Cancer Institute (2016)

The 8q24 region harbors multiple risk variants for distinct cancers, including >8 for prostate cancer. In this study, we conducted fine mapping of the 8q24 risk region (127.8–128.8Mb) in search of novel associations with common and rare variation in 4853 prostate cancer case patients and 4678 control subjects of African ancestry. All statistical tests were two-sided. We identified three independent associations at P values of less than 5.00×10 –8 , all of which were replicated in studies from Ghana and Uganda (combined sample = 5869 case patients, 5615 control subjects; rs114798100: risk allele frequency [RAF] = 0.04, per-allele odds ratio [OR] = 2.31, 95% confidence interval [CI] = 2.04 to 2.61, P = 2.38×10 –40 ; rs72725879: RAF = 0.33, OR = 1.37, 95% CI = 1.30 to 1.45, P = 3.04×10 –27 ; and rs111906932: RAF = 0.03, OR = 1.79, 95% CI = 1.53 to 2.08, P = 1.39×10 –13 ). Risk variants rs114798100 and rs111906923 are only found in men of African ancestry, with rs111906923 representing a novel association signal. The three variants are located within or near a number of prostate cancer–associated long noncoding RNAs (lncRNAs), including PRNCR1 , PCAT1, and PCAT2 . These findings highlight ancestry-specific risk variation and implicate prostate-specific lncRNAs at the 8q24 prostate cancer susceptibility region.