tbuckley/cabot-search huggingface dataset:
PTU-008 Are Patients Undergoing Endoscopic Mucosal Resection for Colorectal Lesions Appropriately Assessed and Referred Prior to Their Procedure
Authors: R Preedy, C Wilkins, K Besherdas
Journal: Gut (2016)

<h3>Introduction</h3> Endoscopic Mucosal Resection (EMR) has been developed for minimally invasive endoscopic removal of large benign and early malignant lesions. Before carrying out colorectal EMR, it is important to characterise the lesion for removal distinguishing between adenoma and adenocarcinoma and the marginal demarcation of the lesion. There are a number of tools an endoscopist can use to characterise a lesion such as observation (e.g. lesion colour, presence of depression and use of the Paris classification) as well as more advanced techniques such as chromo-endoscopic observation (using Kudo classification) and then check for non-lifting sign in presumed colorectal cancers <h3>Methods</h3> A single centre, retrospective analysis in a large London NHS Foundation Hospital was performed. All patients undergoing EMR were identified using Unisoft Endoscopy reporting software across a period of 12 months (Jan 2015-Jan2016). Data was collected regarding the referral, EMR procedure and the patients’ histological diagnosis. <h3>Results</h3> 32 patients were referred and underwent EMR with colorectal lesions greater then 2 cm in size. 23 lesions were accurately described in terms of size. 17 lesions were only described in terms of polyp, with no further distinguishing features. Only 9 of the lesions were commented on with regards to Pitt pattern or Paris classification. 3 lesions were identified as cancerous at the time of endoscopy with only one checked for lift sign. 13 lesions were biopsied, prior to EMR. 6 lesions were rectal and only 8 out of the remaining lesions were tattooed. In referral of the lesions 7 had specified the number of units required for the EMR procedure, 3 were referred for MDT discussion the rest had no further details. <h3>Conclusion</h3> Our case series shows a wide variation in practice in regards to lesion description which can have detrimental effects on patient care. A large number of polyps referrals to EMR are not clearly described in terms of Paris or Kudo classification and the absence of the non-lifting sign. The planning of EMR could be made easier if the pre-EMR assessment included size of the lesion, and clear description with regards to pit pattern and Paris classification. In addition allowing adequate time can be difficulty without a clear lesion description. Regular auditing and presentation go some way to improving practice in a department but endoscopists can come from different departments, be locums or endoscopy can be out sourced. Our opinion would be to ensure that cues are placed in the reporting software to enable accurate assessment and management of lesion considered for EMR as an alternative to EMR endoscopist having to repeat the colonoscopy to assess the lesion prior to scheduling the EMR with appropriate length of time to perform to the procedure. <h3>Disclosure of Interest</h3> None Declared
ATP Acts as Danger Associated Molecular Pattern and Enhances Acute Graft-Versus-Host Disease Severity Via P2×7-R.
Authors: Konrad Wilhelm, Tobias Müller, Jayanthi Ganesan, Christoph Dürr, Ulrike Gerlach, Alf Zerweck, Jürgen Finke, Marco Idzko, Robert Zeiser
Journal: Blood (2009)
CML Patients with Resistance to Tyrosine Kinase Inhibitors and without BCR-ABL1 Resistance Mutation Frequently Carry Other Gene Mutations
Authors: Susanne Schnittger, Claudia Haferlach, Niroshan Nadarajah, Manja Meggendorfer, Annette Fasan, Dominic Rose, Tamara Alpermann, Wolfgang Kern, Torsten Haferlach
Journal: Blood (2014)
Inhibition of STAT3 Reverses the Resistance to Histone Deacetylase Inhibitors Induced By Interleukin-6 in Chronic Lymphocytic Leukemia Cells
Authors: Kang Lu, Xin Wang, Xiaosheng Fang, Lili Feng, Na Chen, Peipei Li, Xinyu Li, Lingyun Geng
Journal: Blood (2014)
Leukemia Inhibitory Factor (LIF) Is Secreted by Marrow-Derived Human Mesenchymal Stem Cells (huMSC) and Inhibits Umbilical Cord Blood (UCB) Hematopoietic Stem Cell (HSC) Proliferation at Early Time Points During In Vitro Expansion.
Authors: Phil Paul, Margaret Forster, Graham Chapman, Mathew Lesniewski, Mary J. Laughlin
Journal: Blood (2010)
SP0147 A Self-Determined Life with A Rheumatic Disease? How Can Social Participation Be Preserved or Obtained and How Can Barriers Be Overcome?
Authors: W. Mau
Journal: Annals of the Rheumatic Diseases (2016)

Health care professionals are increasingly aware of the multifaceted burden of rheumatic and musculoskeletal diseases (RMDs). Aside from typical symptoms such as pain and limited range of motion of the affected joints or other body parts the patients frequently suffer as much from limited social participation and even isolation. Reduced participation in the labor force associated with high indirect costs for society and potential effects of expensive medications have gained increasing attention among researchers and health care insurances. However, other affected social roles concerning family, friends, and leisure activities have been less focused, even though they may be more prominent for individuals with RMDs than working life. The experience of limited social participation depends on medical factors such as disease severity and treatment but also on mostly neglected non-medical environmental and personal factors (i.e., social network and services, individual skills and preferences). Low communication skills may be significant barriers to social participation. In a nationwide project funded by the German League against Rheumatism (GLR) persons with RMDs reported difficulties in disease-related conversations across various situations. Significant factors of RMD-related everyday communication were identified. Based on the results, a training to enhance the communication skills of persons with RMDs in various situations significant for social participation is underway. The GLR offers various other services that facilitate social participation of individuals with RMDs. These services were evaluated by different RMD groups in order to identify the potential for further adjustment according the patients9 preferences. <h3>Disclosure of Interest</h3> None declared
T Cell-Depleted Related Haploidentical Peripheral Blood Stem Cell Transplantation in a Patient with Fanconi Anemia. Cagliari Experience.
Authors: Maria Adele Sanna, Maria Grazia Orofino, Fausto Cossu, Maria Carmen Addari, Antonio Piroddi, Giuseppa Fabiana Rizzo, Manuela Badiali, Renzo Galanello, Francesca Argiolu
Journal: Blood (2004)
Specific MLL Partner Genes in Infant Acute Lymphoblastic Leukemia (ALL) Associated with Outcome Are Linked to Age and White Blood Cell Count (WBC) at Diagnosis: A Report On the Children's Oncology Group (COG) P9407 Trial.
Authors: Blaine W. Robinson, Meenakshi Devidas, Andrew J. Carroll, Richard C. Harvey, Nyla A. Heerema, Cheryl L. Willman, Amanda R. Hudome, Elliot C. Woods, Nancy C. Ballantyne, Gregory H. Reaman, Joanne M. Hilden, Bruce M. Camitta, Naomi J. Winick, William L. Carroll, Stephen P Hunger, Zoann E. Dreyer, Carolyn A. Felix
Journal: Blood (2009)
Shwachman-Diamond Syndrome: Development of a North American Registry to Assess Long-Term Outcomes, Risk of Leukemia and Other Complications.
Authors: Akiko Shimamura, Audrey Anna Bolyard, Tracy M Marrero, Melissa Alvendia, Lynda Ellis, Johanna M Rommens, Richard E. Harris, Peter Durie, Yigal Dror, David C. Dale
Journal: Blood (2009)
Body Mass Index Is Not Associated with Early Treatment Response or Clinical Outcome in Children with Acute Lymphoblastic Leukemia
Authors: Hesham Eissa, Yinmei Zhou, John C Panetta, Emily Browne, Sima Jeha, Dario Campana, William E. Evans, Ching-Hon Pui, Mary V. Relling, Hiroto Inaba
Journal: Blood (2015)
AB0916 Adult-Onset Still's Disease-Experience over Last Five Years
Authors: P.S. Sagdeo, C. Balakrishnan, T. Parikh, G. Mangat, Y. Gc
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Adult onset still9s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology seen by a rheumatologist. There is limited data about this disease especially from our country. <h3>Objectives</h3> To study the clinical profile of AOSD patients in a tertiary care hospital. <h3>Methods</h3> A 5 year (2009–2014) retrospective analysis was done of patients with AOSD (Diagnosed using the Yamaguchi criteria). Their clinical features, laboratory findings at presentation, disease course, treatment and outcomes were analyzed. <h3>Results</h3> 14 patients with AOSD according to Yamaguchi criteria were enrolled. The mean age at disease onset was 43.57±16.91 years and the male to female ratio was 4:3. The mean duration of symptoms prior to diagnosis was 2.2 months (range 1–6 months). The most common clinical manifestations were fever (n=14), articular symptoms (n=14), rash (n=7), weight loss (n=7), sore throat (n=4), Lymphadenopathy (n=8), hepatomegaly (n=5), splenomegaly (n=3) and serositis (n=4). Most common joints involved were knee (n=9) followed by wrist (n=7).Neutrophilic leucocytosis was seen in 13, thrombocytosis was seen in 4 patients. Elevated ESR and Ferritin levels were present in all, with a mean of 70±35.18 mm/hr and 3966.35±2988 ng/ml respectively. Hepatic enzymes were elevated in 6. The mean duration of follow up was 18.71±16.99 months. Prednisolone was used in all while methotrexate was used in 12 patients; one patient each required sulfasalazine and cyclosporine. Tender joint and swollen joint counts displayed a progressive reduction on follow up. During treatment, we observed a resolution of fever in all patients. On first follow up mean ferritin levels decreased from 3966.35±2988 to 3018±699 ng/ml. Course of the disease was monophasic in 7 intermittent in 4 and chronic in 3 patients. <h3>Conclusions</h3> 1.Fever and joint symptoms were the most common presenting symptom. 2.Steroids and methotrexate was most commonly used for treatment. 3.Majority of patients had clinical improvement with resolution of systemic and joint symptoms. <h3>References</h3> Singh S, Samant R, and Joshi VR: Adult onset Still9s disease: a study of 14 cases. Clin Rheumatol 2008; 27: pp. 35–39. Kong XD, Xu D, Zhang W, et al: Clinical features and prognosis in adult-onset still9s disease: a study of 104 cases. Clin Rheumatol 2010; 29: pp. 1015–1019. Mitamura M, Tada Y, Koarada S, et al: Cyclosporin A treatment for Japanese patients with severe adult-onset Still9s disease. Mod Rheumatol 2009; 19: pp. 57–63 <h3>Disclosure of Interest</h3> None declared
Donor’s Mannan-Binding Lectin (MBL) Gene Polymorphism Is Associated with Invasive Fungal Infection Following Allogeneic Stem Cell Transplantation.
Authors: Miquel Granell, Alvaro Urbano-Ispizua, Francisco Lozano, Montserrat Rovira, Francesc Fernandez-Aviles, Mar Ortega, Carla Uriburu, Carme Talarn, Carmen Martinez, Belen Suarez, Anna Guardia, Enric Carreras, Emili Montserrat
Journal: Blood (2004)
Post-Chemotherapy Brain Irradiation in Primary CNS Lymphomas: Impact on Survival of Different Fields and Doses.
Authors: Andres JM Ferreri, Chiara Verona, Letterio Salvatore Politi, Lucia Perna, Anna Chiara, Marco Foppoli, Giada Licata, Silvia Mappa, Fabio Ciceri, Piero Picozzi, Alberto Franzin, Silvia Govi, Maurilio Ponzoni, Maria Rosa Terreni, Eugenio Villa, Michele Reni
Journal: Blood (2009)
QRS-T Patterns in Multiple Precordial Leads that May Be Mistaken for Myocardial Infarction
Authors: GORDON B. MYERS
Journal: Circulation (1950)

The electrocardiograms of patients in whom myocardial infarction was excluded at autopsy are presented to bring out the following features of left ventricular hypertrophy that may be mistaken for myocardial infarction: (1) QS patterns and/or abnormal RS-T elevation in leads from the right precordium; (2) abnormal Q waves, multiphasic QRS and/or cove plane inversion of the T waves in leads from the transitional zone; (3) prominent Q waves, marked RS-T depression and/or sharply inverted T waves in leads from the left axilla.
Long-Term Relapse-Free Survival and Overall Survival of Patients with Acquired Primary Idiopathic Pure Red Cell Aplasia Receiving Cyclosporine: A Nationwide Cohort Study in Japan for the PRCA Collaborative Study Group.
Authors: Ken-ichi Sawada, Makoto Hirokawa, Naohito Fujishima, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, Keiya Ozawa
Journal: Blood (2006)
AB0510 Chronic Daily Headache Deteriorates The Quality of Life in Korean Patients with Systemic Lupus Erythematosus
Authors: S.-H. Kim, H.-J. Jeong, J.-M. Kim, Y.S. Kim, H.-S. Kim, S.-J. Hong, S.-S. Kim, C.-N. Son
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Headaches is common in patients with systemic lupus erythematosus (SLE) [1]. However, the lack of specific clinical distinctions for headache in SLE has made it difficult to elucidate its pathophysiology. Chronic daily headache (CDH) is a category of headache disorders that occurs more than 15 days per month and is associated with a profound decline in the quality of life [2]. <h3>Objectives</h3> The aim of this study is to investigate the clinical characteristics of CDH in patients with SLE and their association with disease severity and the quality of life. <h3>Methods</h3> A total of 40 consecutive patients with SLE participated in the survey. We investigated headache characteristics, visual analogue scale (VAS) for pain, and six-question headache impact test (HIT-6) to evaluate the impact of headache on the quality of life. The patients underwent required blood tests for assessment of disease activity using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). <h3>Results</h3> Six patients (15%) met the criteria for CDH. The total score of HIT-6 is significantly higher in SLE patients with CDH than in those patients who suffered from headache without CDH (P=0.027). SLE patients with CDH in particular had a higher prevalence of "wish could lie down" than those who suffered from headache without CDH (P=0.017). The multivariate regression analysis indicates that the headache days per month was a predictor for headache-related disabilities. <h3>Conclusions</h3> As far as we know, this is the first study of its kind to evaluate the correlation of CDH and the quality of life in Korean patients with SLE. CDH may deteriorate the quality of life in patients with SLE. <h3>References</h3> Cuadrado MJ, Sanna G. Headache and systemic lupus erythematosus. Lupus 2003;12:943–6. Pascual J, Colas R, Castillo J. Epidemiology of chronic daily headache. Curr Pain Headache Rep 2001;5:529–36. <h3>Disclosure of Interest</h3> None declared
The Impact of Hemoglobin on Total Mortality in Elderly Asian-American Men: The Honolulu Heart Program.
Authors: Beatriz L. Rodriguez, Robert D. Abbott, Samir H. Mody, Kamal Masaki, Bradley Willcox, Helen Petrovitch, Webster Ross, Irwin Schatz, Patricia Blanchette, J. David Curb, Richard C. Woodman
Journal: Blood (2005)
SAT0351 Tocilizumab in Giant Cell Arteritis: A Multicentre Open-Label Study OF34 Patients
Authors: A. Regent, S. Redeker, A. Deroux, P. Kieffer, K. Ly, M. Dougados, L. Eric, C. Larroche, L. Guillevin, L. Bouillet, O. Espitia, N. Costedoat-Chalumeau, M. Soubrier, B. Brihaye, F. Liferman, G. Lefebvre, X. Puechal, L. Mouthon, E. Toussirot
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Giant cell arteritis (GCA) is a vasculitis of large and medium sized arteries affecting people older than 50 years. Glucocorticosteroids (GC) are the mainstay of therapy but relapses are common, resulting in prolonged treatment course and adverse events. IL-6 correlates with disease activity of GCA and temporal artery biopsy samples show enhanced IL-6 production. Cases series and open label studies reported the efficacy of tocilizumab (TCZ) on symptoms and inflamamtory markers in GCA. <h3>Objectives</h3> To report the French experience on the efficacy and safety of TCZ in patients with GCA and the evolution after treatment withdrawal. <h3>Methods</h3> A retrospective multicenter study on patients treated with TCZ for their GCA was conducted. Treatment efficacy was evaluated at a clinical and biological level. Side effects and evolution after treatment withdrawal were also recorded. <h3>Results</h3> Thirty-four patients (27 women and 7 males) aged 70.5±8.2 (mean±SD) were included. Diagnosis of GCA was based on the ACR criteria (30 patients) and/or on imaging abnormalities suggestive of GCA (8 patients). Giant cell disease was treated by GC and another immunosuppressant was added before TCZ introduction in 20/34 patients. Tocilizumab (8 mg/kg monthly) was introduced after a mean disease evolution of 18 months (0–107). It was efficient in all but 6 patients who still had mild symptoms while CRP was reduced from 40.4 mg/L to 1.5 mg/L (p&lt;0,0001) and GC were tapered from 26.3 to 10.3 mg/day (p&lt;0.0001). One patient died from a septic shock and 3 patients had to stop TCZ for adverse events. Among the 23 patients who stopped treatment (planned medical decision in 20 cases and side effects in 3 cases) eight patients experienced relapses that occurred after a mean of 3.5±1.3 months. <h3>Conclusions</h3> TCZ therapy leads to rapid and maintained improvement in patients with refractory GCA. However, side effects should be kept in mind in this population. Questions remain regarding the suspensive nature of this treatment and this should be specifically studied in future studies. <h3>Disclosure of Interest</h3> None declared
Randomized Phase II Study Evaluating the Efficacy and Safety of Romiplostim Treatment of Patients with Low or Intermediate Risk Myelodysplastic Syndrome (MDS) Receiving Lenalidomide.
Authors: Roger M Lyons, Richard A. Larson, Michael A. Kosmo, Sunil Gandhi, Delong Liu, Marc Chernoff, Luke Dreisbach, Carmen Matei, Kuolong Hu, Janet L. Franklin, Dietmar Berger
Journal: Blood (2009)
Noninvasive Genotyping and Assessment of Treatment Response in Diffuse Large B Cell Lymphoma
Authors: Florian Scherer, David M. Kurtz, Aaron M. Newman, Henning Stehr, Chih Long Liu, Li Zhou, Alexander F.M. Craig, Jacob J. Chabon, Alexander F. Lovejoy, Daniel M. Klass, Cynthia Glover, Robert S. Ohgami, Christian A. Kunder, Brendan C. Visser, George Poultsides, Ronald Levy, Maximilian Diehn, Ash A. Alizadeh
Journal: Blood (2015)
The Interaction Between DOT1L and AF10 Is Required for H3K79 Dimethylation and MLL-AF9 Leukemia
Authors: Aniruddha J Deshpande, Liying Chen, Kathrin M Bernt, Stuart Dias, Deepti Banka, Amit U. Sinha, David Chen, Natalie Punt, James E. Bradner, Scott A. Armstrong
Journal: Blood (2012)
Prophylactic Rituximab After Allogeneic Stem Cell Transplantation Prevents Steroid-Requiring Chronic Graft-Vs.Host Disease
Authors: Corey Cutler, Lixian Sun, Haesook Kim, Stefanie Sarantopoulos, Bhavjot Bindra, Yi-Bin Chen, Jacalyn Rosenblatt, Philippe Armand, John Koreth, Vincent T. Ho, Edwin P. Alyea, Robert J. Soiffer, Jerome Ritz, Joseph H. Antin
Journal: Blood (2010)
SAT0448 A Comparison of The Different Quantitative Sensory Testing Measurements Addressing Pain Mechanisms in People with Osteoarthritis
Authors: H. Hassan, D.F. McWilliams, D. Wilson, N. Frowd, D.A. Walsh
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> People with osteoarthritis (OA) can experience both nociceptive pain, as a result of local joint damage, and pain that is indicative of abnormal central pain processing. Quantitative sensory testing (QST) is psychophysical testing of somatosensory function and can been used to investigate somatosensory abnormalities in people with OA. <h3>Objectives</h3> The aim of this study was to assess the reliability discriminant ability of two different mechanical stimuli for QST measurements, pressure and punctate, in people with knee OA and healthy participants. <h3>Methods</h3> Twenty six knee OA participants and 25 healthy participants were recruited. QST was performed in all participants at three sites on the body (sternum, index knee and anterior tibia). Two mechanical QST modalities (pressure and punctate) were performed. Pressure pain threshold (PPT) was assessed using digital algometry. Punctate QST measurements, {mechanical pain threshold (MPT), mechanical pain sensitivity (MPS) and wind-up ratio (WUR)}, were assessed using pinprick stimulators. The procedures were repeated during a second assessment four weeks later by the same examiner to determine repeatability. All participants completed the Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire (Rasch transformed). <h3>Results</h3> The mean age for OA participants was 66 years (standard deviation (SD) (9), (50% female) and for the healthy participants was 58 years (SD 11), (48% female). People with knee OA demonstrated significantly higher values on ICOAP Rasch transformed; Intermittent {mean 7.13 (4.47) and Constant mean 4.40 (4.47)} than healthy participants; Intermittent {mean 1.12 (2.31) and Constant {mean 0.29 (1.03)} (<i>P</i>&lt;0.001). The test-retest reliability of the QST measurements before and after 4 weeks interval expressed as intraclass correlation coefficients (ICCs) are given in Table 1. People with knee OA had significantly lower PPT at knee and tibia than normal controls (Graph). Differences between OA and control groups remained significant after adjustment for age and sex. Whereas there were no significant differences found in any punctate QST measurements between knee OA and healthy participants. <h3>Conclusions</h3> This study demonstrated that PPT is a reliable QST measurement with less variability compared to other mechanical QST measurements assessed. PPT at the tibia, a site distal to the affected joint, is believed to reflect augmented central pain processing. PPT may be a preferred QST modality to investigate altered central pain processing in people with OA. <h3>References</h3> R. Rolke et al. Pain 123 (2006), 231 – 243. A.K. Suokas et al. Osteoarthritis Cartilage 10 (2012), 1075–1085 V. Wylde et al. Osteoarthritis Cartilage 19 (2011), 655–658 M Pigg et al. Pain 148 (2010), 220 – 226. <h3>Disclosure of Interest</h3> None declared