tbuckley/cabot-search huggingface dataset:
OP0073 Prognostic factors for return to work in patients with sciatica
Authors: L. Grøvle, J.I. Brox, A.J. Haugen, A. Keller, B. Natvig, M. Grotle
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Little is known about the prognostic factors for work-related outcomes of sciatica caused by disc herniation. <h3>Objectives</h3> To identify prognostic factors for return to work (RTW) during a 2-year follow-up among sciatica patients referred to secondary care. <h3>Methods</h3> The setting was a multicenter prospective cohort study including 466 patients. Study participation did not involve any specific type of intervention. In patients with severe symptoms, surgery was performed at the discretion of each center. Administrative data from the National Sickness Benefit Register were accessed for 227 patients. Two patient samples were used. Sample (A) comprised patients who at the time of inclusion in the cohort reported being on partial sick leave or complete sick leave, or were undergoing rehabilitation because of back pain/sciatica. Sample (B) comprised patients who, according to the sickness benefit register, at the time of inclusion received sickness benefits or rehabilitation allowances because of back pain/sciatica. In sample (A), the outcome was self-reported return to full-time work at the 2-year follow-up. In sample (B), the outcome was time to first sustained RTW, defined as the first period of &gt;60 days without receiving benefits from the register. Analyses were performed by multivariate logistic regression and Cox proportional hazard modeling. <h3>Results</h3> One-fourth of the patients were still out of work at the 2-year follow-up. In sample A (n=237), younger age, better general health, lower baseline sciatica bothersomeness, less fear avoidance–work, and a negative straight-leg-raising test result were significantly associated with a higher probability of RTW at the 2-year follow-up. Surgery was not significantly associated with the outcome. In sample B (n=125), a previous history of sciatica, duration of the current sciatica episode &gt;3 months, and greater sciatica bothersomeness, fear avoidance–work, and back pain were significantly associated with a longer time to sustained RTW. Surgery was negatively associated with time to sustained RTW both in univariate (hazard ratio,HR 0.60; 95% confidence interval (CI) 0.39, 0.93; p=0.02) and in multivariate analysis (HR 0.49; 95% CI 0.31, 0.79; p=0.003). <h3>Conclusions</h3> The baseline factors associated with RTW identified in multivariate analysis were age, general health, previous history of sciatica, duration of the current episode, baseline sciatica bothersomeness, fear avoidance–work, back pain, and the straight-leg-raising test result. Surgical treatment was associated with slower RTW. <h3>Disclosure of Interest</h3> None Declared
SAT0381 The use of bisphosphonates in the treatment of low bone mineral density in adults with sickle cell anemia
Authors: T. Backa Cico, S. Kullolli, I. Harizi, E. Rrapushi, F. Kraja, E. Skuqi, A. Gjata, M. Kreka, G. Llangozi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Sickle cell disease (SCD) is a prevalent genetic disorder in which sickle hemoglobin leads to tissue hypoxia and adverse effects on bone. Several studies have shown an overall reduction in bone mineral density (BMD), attributed to marrow hyperplasia, in patients with SCD. Compared with normal subjects from the general population, found that the patients with SCD had lower BMD values in all scan regions. In particular, vertebral osteoporosis is common in patients with sickle cell disease. Minimal data exist on the prevalence of low BMD and its treatment in Albanian adults with SCD. <h3>Objectives</h3> The aim of our study was to describe the prevalence of BMD in adults with SCD in Albania population and to evaluate the effectiveness of the bisphosphonates in the treatment of low BMD. <h3>Methods</h3> In this cross-sectioonal study, we collected data from 100 consecutive adult patients (55 male and 45 female, mean age 22.5±1.5 years) with SCD and low BMD who were treated at the University Service of Rheumatology, University Hospital Center Mother Theresa, Tirana, Albania, during 2010. BMD measurement was done using dual energy X-ray absorbtiometry (DEXA) at lumbar spine. Osteopenia and osteoporosis were diagnosed according to WHO criteria. All patients were treated with 10mg alendronate per day and 600UI of vitamin D3 and 1g of calcium carbonate. We evaluated their BMD after six and twelve months of treatment. <h3>Results</h3> Median lowest T-score was -2.2 (range: -3.4 to -1.1). Seventy-eight per cent of the patients (n=78) had osteoporosis and 22% (n=22) had osteopenia. After treatment, bone mineral density decreased by 13.8% (<i>P</i>&lt;.001) and 7.8% (<i>P</i>=0.003) in osteoporotic patients and by 6.5% (<i>P</i>=0.002) and 3.6% (<i>P</i>=0.141) in osteopenic patients at 6 and 12 months, respectively. Upon adjustment for age and sex, T-score was increased significantly at 6 and 12 months of treatment compared with pretreatment (-1.9±0.4 and -0.9±0.3 vs. -2.1±0.3, p&lt;0.001) <h3>Conclusions</h3> The prevalence of osteoporosis in young adults with SCD is very high. Our results suggest that antiresorptive treatment with biphosphonates can improve the bone mineral density. Additional studies are needed to determine the long-term effects of this treatment. <h3>Disclosure of Interest</h3> None Declared
Abstract 2009: Histone deacetylase inhibitors (HDI) down-regulate Ron kinase and synergize with Ron knockdown or Ron monoclonal antibody 41A10to treat pancreatic cancer
Authors: Yi Zou, Gillian Howell, Michael G. Brattain
Journal: Cancer Research (2011)

Abstract Receptor tyrosine kinase Ron (recepteur d'origine nantais) has been reported to be overexpressed in a panel of pancreatic cancer cells, as well as in tissue samples from pancreatic cancer patients and has been correlated to late stages of pancreatic cancer. Here we hypothesize that Ron kinase can be served as a potential therapeutic target. Our study showed that Ron-specific shRNA significantly altered oncogenic signaling as reflected by reduced pRon, pAkt and pERK in conjunction with reduced cell motility, as evidenced by wound healing assays and transwell assays. Ron knockdown also reduced HIF1α expression. HIF1α is constitutively expressed in many pancreatic cancer cells and has been reported to be a transcription factor for Ron and CXCR4 gene expression, indicating the reciprocal control for these two proteins. Targeting HIF1α and Ron may represent a novel therapeutic strategy for Ron-overexpressing pancreatic cancer patients. Histone deacetylase (HDAC) inhibitors have been reported to target HIF1α gene expression and alter the interaction of HSP70/90 with their client proteins through disruption of HSP70/HSP90 by HDAC6. We demonstrate here that HDAC inhibitors TSA and Panobinostat significantly reduced HIF1α, Ron kinase and CXCR4 expression in pancreatic cancer cells, which was associated with attenuation of pAkt and pERK. Thus our work indicates that HDAC inhibitor therapy targets both Ron and HIF1α. Our future work will demonstrate that Panobinostat can synergize with Ron knockdown or Ron monoclonal antibody to reduce cell growth by colony formation assay. Molecular mechanism will also be investigated. Ron, HIF1α and CXCR4 were reported to increase tumor metastasis. Whether HDI such as Panobinostat alone or in combination with Ron knockdown or Ron monoclonal antibody can reduce metastasis through downregulation of these metastasis related genes will be further investigated. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2009. doi:10.1158/1538-7445.AM2011-2009
Stat Bite: Knowledge of Breast Cancer Risk, by Age
Authors: R. Breslow, L. Kessler
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite: Knowledge of Breast Cancer Risk, by Age Get access Rosalind Breslow, Ph.D., Rosalind Breslow, Ph.D. Applied Research BranchNCI Search for other works by this author on: Oxford Academic PubMed Google Scholar Larry Kessler, Sc.D. Larry Kessler, Sc.D. Applied Research BranchNCI Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 15, 2 August 1995, Page 1109, https://doi.org/10.1093/jnci/87.15.1109 Published: 02 August 1995
Hospital waiting lists grow by 13% in England
Authors: J. Warden
Journal: BMJ (1997)

Emergency measures to ease winter pressures on the NHS are being ordered by ministers as the health service in England faces potential breakdown. The aim is to divert available resources to cope with emergency admissions. As a result, waiting lists for elective treatment that have risen substantially will lengthen still further.

Although no new funding is envisaged beyond what has already been announced, steps are being taken to ease the financial straitjacket on trusts. The health minister, Alan Milburn, intends to bring forward to October, from February, the allocations to …
ESTUDIO PROSPECTIVO SOBRE LAS INDICACIONES, RESULTADOS Y RELEVANCIA CLÍNICA DE LA CÁPSULA ENDOSCÓPICA EN UN CENTRO DE TERCER NIVEL
Authors: J García Lledó, B Merino Rodríguez, Ó Nogales Rincón, C González Asanza, M San Juan, P Lastra, L Pérez, P Menchén Fernández-Pacheco
Journal: Endoscopy (2014)

Introducción: La cápsula endoscópica constituye la herramienta diagnóstica de elección para el estudio del intestino delgado. Aunque la hemorragia digestiva de origen oscuro sigue siendo su principal indicación, cada vez son más sus indicaciones.
Abstract 760: Fem1b attenuates the transcriptional activity of Gli1 by promoting the ubiquitin mediated degradation of Gli1.
Authors: Andrew S. Gilder, Deyin Lu, Joseph F. Maher
Journal: Cancer Research (2013)

Abstract Gli1 is a member of the Gli family of zinc finger transcription factors that functions in stem cell biology, and as an oncogene in malignant transformation. The Hedgehog signaling pathway in flies and mammals shares homology to the sex determination pathway of C. elegans in which the Gli-like transcription factor TRA-1 is regulated by the ubiquitin ligase adapter FEM-1. Here we provide evidence that the mammalian FEM-1 homolog Fem1b regulates Gli1 transcriptional activity. Consistent with this, we demonstrate an interaction between Fem1b and Gli1, and show that Fem1b promotes the ubiquitylation and proteasome-mediated degradation of Gli1. Fem1b mediated ubiquitylation of Gli1 was dependent on the VHL box domain of Fem1b, shown to interact with Elongin B/C-Cul2-box protein ubiquitin ligases. Fem1b reduced Gli1 transcriptional activity in a reporter assay, and this reduction was also dependent on the VHL box of Fem1b. Given that Gli1 up-regulation promotes tumorigenesis in glioblastoma, medulloblastoma, basal cell carcinoma, and a variety of epithelial malignancies, we hypothesize that Fem1b antagonizes the oncogenic capacity of Gli1 by targeting Gli1 for ubiquitin-mediated destruction in the proteasome. Citation Format: Andrew S. Gilder, Deyin Lu, Joseph F. Maher. Fem1b attenuates the transcriptional activity of Gli1 by promoting the ubiquitin mediated degradation of Gli1. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 760. doi:10.1158/1538-7445.AM2013-760
Multi-clonal expansion of unique human T-lymphotropic virus type-I-infected T cells with high growth potential in response to interleukin-2 in prodromal phase of adult T cell leukemia
Authors: T Hata, T Fujimoto, H Tsushima, K Murata, K Tsukasaki, S Atogami, H Sohda, S Honda, M Mine, Y Yamada, S Ikeda, S Kamihira, M Tomonaga
Journal: Leukemia (1999)
P68 Time-course Of Human Rhinovirus Infection And Upper Respiratory Tract Symptoms During Copd Exacerbations
Authors: S. George, S. Brill, J. Allinson, R. Singh, B. Kowlessar, R. Sapsford, G. Donaldson, J. Wedzicha
Journal: Thorax (2014)

<h3>Introduction</h3> Human rhinoviruses (HRV) are the main aetiological agents of virus-associated COPD exacerbations (Seemungal <i>et al</i>. AJRCCM 2001). The relationship between upper respiratory tract symptoms and HRV load at exacerbation presentation (ExP) and during recovery has not been described in naturally-occurring exacerbations. We quantified changes in airway HRV load at ExP and during the recovery period, in patients reporting symptoms of a cold, sore throat, or both. <h3>Methods</h3> Patients in the London COPD cohort recorded new or increased respiratory symptoms on daily diary cards. Exacerbations were defined as an increase in respiratory symptoms for two consecutive days, with at least one symptom being major (dyspnoea, sputum purulence or volume) and the other a major or minor (wheeze, cold, sore throat, cough). Reverse-transcription quantitative PCR was used to detect and quantify HRV in 106 sputum samples collected at ExP (n = 38) and days 3 (n = 16), 7 (n = 27), 14 (n = 16), 35 (n = 6) and 56 (n = 3) following. <h3>Results</h3> HRV load decreased significantly from ExP to Day 3 in samples associated with either cold symptoms (p &lt; 0.001) or sore throat (p = 0.049) but not in those associated with both symptoms (Figure 1). At Day 3 the HRV load in samples with both symptoms (n = 5) was significantly higher than in those with cold symptoms only (n = 9) (10<sup>4.22(3.94–4.88)</sup> vs 10<sup>0.55(0–1.98)</sup> pfu/ml; p = 0.002) but not for those with a sore throat only (n = 2) (10<sup>0.89(0–0.89)</sup> pfu/ml; p = 0.095). At Day 7, the median (IQR) HRV load in samples with both symptoms (n = 4) (10<sup>4.48(1.85–7.28) </sup>pfu/ml) was significantly higher than in those with cold symptoms only (n = 19) (10<sup>0(0–2.74) </sup>pfu/ml; p = 0.018) or a sore throat only (n = 4) (10<sup>0(0–0) </sup>pfu/ml; p = 0.029). There was no significant difference at subsequent time-points. <h3>Conclusion</h3> Patients reporting both cold symptoms and a sore throat as part of a COPD exacerbation had higher HRV loads than those with just one symptom until after Day 7 post-exacerbation. In patients with both symptoms, the HRV load remained higher for a longer period of time than in patients with only one symptom, which may suggest longer recovery times for more symptomatic patients. These results may inform the timing of administration of antiviral therapies at COPD exacerbation.
AB0877 Non Pharmalogical Treatment of Sciatica, A Comparative Study
Authors: S. Miladi, K. Ben Abdelghani, L. Souabni, S. Kassab, S. Chekili, A. Laatar, L. Zakraoui
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Sciatica is a common disease and can be source of pain and disability. Pharmacological treatment is often prescribed but sometimes adverse effects occur. Acupuncture is an interesting alternative when medical treatment is prohibited. <h3>Objectives</h3> Our aim was to assess the relation between the pain threshold and therapeutic effects of acupuncture for sciatica. And then to compare the effect of acupuncture in monotherapy or associated with migratory sucker. <h3>Methods</h3> Fourty patients suffering from sciatica were prospectively screened and devised into 2 groups: G1 treated by acupuncture and G2 treated by acupuncture and migratory sucker. All patients were treated 3 times per week for 20 minutes for a total of 10 sessions. The visual analogical scale (VAS), the straight leg raising test (SLR), and Schober index were assessed at baseline, at the third, sixth and last visit. <h3>Results</h3> Among patients selected, 38 finished the protocol, 19 both in G1 and G2. The sciatica ran since 42 months [1-168 months] before inclusion. A significant decrease of VAS, SLR was noted for both groups at the end of the study. A significant decrease of distance fingers floor and increase of Schober index was observed only for G2. Comparing the two groups the variation of VAS, SLR, distance fingers floor and Schober index was more important for G2 but it was significant only for distance fingers floor (p&lt;0,05). <h3>Conclusions</h3> Acupuncture seems to be efficient to treat sciatica, especially when associated to migratory sucker. Since this therapy avoids drug9s side effects it should be more considered. <h3>References</h3> Chen MR. The warming acupuncture for treatment of sciatica in 30 cases. J Tradit Chin Med. 2009. C. Jiao. Current situation and prospects on the clinical researches of traditional acupuncture and moxibustion for sciatica. European Journal of Integrative Medicine 2010. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5216
THU0362 Hip Replacement Surgery in Patients with Ankylosing Spondylitis
Authors: T. W. Nystad, B.-T. S. Fevang, L. I. Havelin, O. Furnes, S. A. Lie
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Although TNF-alpha inhibitors by easing pain and restoring function have revolutionized the treatment of patients with ankylosing spondylitis (AS), so far no certain influence on the development of spinal ankylosis has been documented, and it remains to be shown whether TNF-alpha inhibition influences joint destruction and subsequent need for arthroplasty surgery. Consequently, the aim of treatment in AS is still to reduce clinical symptoms. <h3>Objectives</h3> We wished to investigate whether improved treatment has resulted in a diminishing use of arthroplasty surgery. <h3>Methods</h3> Nearly all patients (98%) having undergone an arthroplasty of the hip later than 1987 are registered in the Norwegian Arthroplasty Register (NAR). Data concerning the identity of the patient, diagnosis and date of surgery are among the information recorded. We selected the group of patients having received a hip prosthesis on the basis of AS in the years 1988-2010 (n=534, 73.8% men), and compared the trend in number of procedures being performed annually with the time trend of the same procedure in patients with osteoarthritis (OA) (n=95094, 31.6% men). For statistical analysis we used Poisson regression models to test for the trend, and change in trend over the years. A random effect was included in the model to account for overdispersion in the data. <h3>Results</h3> The frequency of hip prosthesis surgery in both groups increased steadily up until 2002, with a coefficient of 0.028 per year for OA patients (p&lt;0.001), and a coefficient of 0.039 per year for AS patients (p=0.002). Whereas the number of surgical procedures in the OA group continued to rise significantly (p&lt;0.001) with a coefficient of 0.017 per year in the years 2003-2010, there was a trend towards a reduced frequency of hip prosthesis surgery (coefficient of minus 0.022 per year) in the AS group, although the reduction was not statistically significant (p=0.51). <h3>Conclusions</h3> The present study’s major finding was a trend of reduced frequency of hip replacement procedures in patients with AS during the time span 2003-2010 which contrasts the continued increase for OA patients. Up until 2002 the frequency increased significantly in accordance with the general increase in joint replacement surgery. TNF-alpha inhibition was introduced in the treatment of Norwegian AS patients in 2000, and our findings suggest that this medication may alter the prognosis of these patients by reducing large joint arthritis and thus reducing the need for hip replacement surgery. <h3>Disclosure of Interest</h3> None Declared
False-Positive 131I Whole-Body Scan in Well-Differentiated Thyroid Cancer Patient With Respiratory Bronchiolitis
Authors: Tanyaluck Thientunyakit
Journal: Clinical Nuclear Medicine (2013)

(131)I whole-body scan is performed during treatment and follow-up after radioiodine treatment to detect functioning thyroid remnant and metastatic lesions in differentiated thyroid carcinoma (DTC). False-positive scans are rare, but may cause a potential pitfall by misleading to unnecessary radiation exposure from inappropriate radioiodine treatment. We report a case of papillary thyroid cancer patient with false-positive (131)I scan in the lung due to pulmonary bronchiolitis. Clinical correlation and imaging characteristics obtained from additional SPECT/CT images are very helpful to indicate this lesion as a benign condition.
Phase II trial of neoadjuvant 5-fluorouracil, epirubicin and cyclophosphamide (FEC100) followed by weekly paclitaxel and trastuzumab (PH) for HER2 positive breast cancer (Kinki Multidisciplinary Breast Oncology Group; KMBOG-0402).
Authors: N Masuda, T Nakayama, N Matsunami, M Kashiwaba, S Kamigaki, J Yamamura, S Anami, M Takeda, Y Yasumura, T Taguchi
Journal: Cancer Research (2009)

Abstract Abstract #3160 Background: Achievement of pathological complete response (pCR) by primary systemic chemotherapy (PST) correlates with improved disease-free survival in operable breast cancer patients. Based on data of the higher pCR rate with concomitant chemotherapy and trastuzumab (H) presented by the randomized prospective trial (Buzdar AU, et al: JCO 23:3676-85; 2005), we performed a multi-center, prospective phase II study to assess the addition of H to primary systemic chemotherapy in HER2+ pts in Japan.&amp;#x2028; Methods: Generally, the concomitant combination therapy with anthracycline-containing regimens and H is not recommended because of the increasing rate of cardiac toxicity. This study was designed to evaluate the efficacy and safety of PST for the operable breast cancer with HER2+ phenotype. PST is the sequential chemotherapy with 4 cycles of FEC100 followed by 12 times in combination with weekly paclitaxel (P) 80mg/m2 and H 2mg/kg (PH x 12).. The inclusion criteria is pts with histopathologically confirmed invasive breast carcinoma, T1-3N+M0/T2-3N0M0, HER2 positive by FISH or immunohistochemistry (IHC) 3+, PS=0-1, adequate hematologic, renal, hepatic and cardiac function and a written informed consent. The study was designed to detect a pCR rate of &amp;gt;43% in at least 42 pts. The evaluation of pathological response was carried out on all the surgical specimens sliced every 5 mm interval.&amp;#x2028; Results: From Dec 2004 to Dec 2007, 43 pts were enrolled. Pre-reviewed data is now available for all pts: median age 56 [26-75 years]; 15 (35%) pre-menopausal; median clinical tumor size 40 mm [15-80]; 14 (33%) were ER-positive phenotype. All pts had a normal cardiac function before entry and after FEC→PH. No episodes of serious adverse events were reported. Febrile neutropenia was observed on 5 pts (12%). Grade 2 or 3 neuropathy was limited to 4 pts (9%). Other grade 3 non-hematological toxicities were not observed. Two pts requested to stop the treatment with P after 6 times of infusion because of neuropathy, edema and hyperpigmentation on the face, however, they had completed 12 times of H infusion. After PST, breast conservative surgery was done in 38 patients (88%) and mastectomy in 5 (12%). The overall pCR rate was 60% (26/43), and 6 of 26 pts had only component of DICS.&amp;#x2028; Conclusions: In HER2+ pts, PST with FEC100x4 followed by PHx12 was active and promising, achieving high pathological complete response without significant toxicity. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3160.
The limitations of the reverse-engineering approach to cognitive modeling
Authors: Jay G. Rueckl
Journal: Behavioral and Brain Sciences (2012)

Abstract Frost's critique reveals the limitations of the reverse-engineering approach to cognitive modeling – the style of psychological explanation in which a stipulated internal organization (in the form of a computational mechanism) explains a relatively narrow set of phenomena. An alternative is to view organization as both the explanation for some phenomena and a phenomenon to be explained. This move poses new and interesting theoretical challenges for theories of word reading.