tbuckley/cabot-search huggingface dataset:
Abstract 4983: Integrative analysis of DNA copy number and gene expression identifies <i>G3BP1</i> and <i>HIRA</i> as potential therapeutic targets against metastatic oral squamous cell carcinoma
Authors: Chang Xu, Yan Liu, Pei Wang, Wenhong Fan, Melissa P. Upton, John R. Houck, Pawadee Lohavanichbutr, David R. Doody, Neal D. Futran, Lue Ping Zhao, Stephen M. Schwartz, Chu Chen, Eduardo Méndez
Journal: Cancer Research (2011)

Abstract The presence of lymph node metastasis is associated with a 50% reduction of 5-year survival in patients with oral squamous cell carcinoma (OSCC). We set out to combine DNA copy number aberrations (CNAs) with gene expression profiles, to identify CNAs-associated genes dysregulated in metastatic OSCC, and determine whether these genes can be targeted to selectively kill metastatic OSCC tumor cells. Toward this end, we interrogated DNA and RNA of the same OSCC cell populations laser micro-dissected from non-metastatic primary tumors (n=17) and metastatic lymph nodes (n=20) using Affymetrix 250K Nsp single-nucleotide polymorphism (SNP) arrays and U133 Plus 2.0 arrays, respectively. With a false discovery rate (FDR) &amp;lt; 5%, 1988 transcripts were found to be differentially expressed between primary and metastatic OSCC. Out of these, 114 transcripts showed significant correlation between their DNA copy number alternations (estimated using SNPs within 250 kb upstream and downstream of the transcript) and gene expression (FDR &amp;lt; 0.01). Among these CNA-correlated transcripts, 95 had significantly different DNA copy numbers between metastatic and non-metastatic OSCC (FDR &amp;lt;0.01 by Wilcoxon rank test). These 95 transcripts (representing 87 genes) mainly clustered around three genomic locations: 3p25.3-22.1, 9p24.1- 22.3 and 18q21.1-22.3. Among these 87 genes, we selected 28 of the 58 genes that were over-amplified and over-expressed in metastatic OSCC and conducted a high-throughput siRNA-mediated gene knockdown screen in five cell lines derived from primary and lymph node metastatic OSCC. The expression-knockdown of 18 genes showed 30% or more growth suppression in at least one cell line as compared to mock controls in which the cells were treated with transfection reagent only without the siRNA (P &amp;lt; 0.01). In particular, knocking-down G3BP1 and HIRA selectively suppressed the growth of all OSCC cell lines derived from lymph node metastases when compared to non-metastatic lines. Further investigation is warranted to confirm these findings and to examine the biological role of G3BP1 and HIRA in OSCC metastasis and their potential as therapeutic targets. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4983. doi:10.1158/1538-7445.AM2011-4983
Unexpected Finding on I-123 FP-CIT SPECT Leading to the Diagnosis of Cerebral Meningioma
Authors: Ingrid Biancheri-Mounicq, Mathilde Colombié, Jean-Christophe Pin, Aurélien Lecoanet, Frédérique Adam-Tariel
Journal: Clinical Nuclear Medicine (2011)

A 69-year-old woman with a 20-year history of psychiatric disorders was referred to our Nuclear Medicine Department because of an extrapyramidal syndrome. Because the differential diagnosis between neuroleptic-induced parkinsonism and Parkinson disease was difficult, I-123 FP-CIT brain SPECT was performed. The transverse slices demonstrated an unexpected image of the left striatum which seemed moved backward and toward the midline. A space occupying lesion was suspected and later confirmed by CT. This case highlights the significance of structural neuroimaging and of careful check of the striatum morphology.
Cancer Experts Set Research Agenda for Women's Health In the 1990s
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Cancer Experts Set Research Agenda for Women's Health In the 1990s Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 20, 16 October 1991, Pages 1443–1444, https://doi.org/10.1093/jnci/83.20.1443 Published: 16 October 1991
Multifocal plasmacytoma presenting with upper gastrointestinal bleeding, chronic diarrhea, and multiple sites of small-bowel intussusception
Authors: V. Prachayakul, P. Aswakul, M. Deesomsak, A. Pongpaibul
Journal: Endoscopy (2013)

A 48-year-old man was referred to our hospital because of intermittent abdominal pain and chronic diarrhea for 2 months and acute massive upper gastrointestinal bleeding, which had commenced a few days ago. Esophagogastroduodenoscopy (EGD) showed an ulcerating mass in the second part of the duodenum, located just beyond the ampulla ([Fig. 1]). The bleeding was successfully stopped by injecting epinephrine into the tumor followed by spraying with Histoacryl [1] ([Fig. 2]). A few days after the procedure the patient developed acute, severe abdominal pain and nausea and vomiting. Computed tomography (CT) showed intussusception of two long segments of the ileum associated with multiple intraluminal masses. The first segment was in the jejunum and the second was ileocolic intussusception ([Fig. 3]). There were also multiple bony metastases and lymphadenopathy in the paravertebral region. A biopsy sample from the duodenum showed hematological malignancy with plasmacytic differentiation, and was positive for CD45, CD138, c-lambda, and c-kappa, and negative for CD20, CD30, and CD3 ([Fig. 4]). The bone marrow biopsy was compatible with multiple myeloma. After treatment with intravenous chemotherapy, the patient's clinical condition improved and the abdominal pain as well as small-bowel obstruction disappeared a few days later.
Herpes Simplex Virus Type 2 in the United States, 1976 to 1994
Authors: Douglas T. Fleming, Geraldine M. McQuillan, Robert E. Johnson, André J. Nahmias, Sevgi O. Aral, Francis K. Lee, Michael E. St. Louis
Journal: New England Journal of Medicine (1997)

Herpes simplex virus type 2 (HSV-2) infection is usually transmitted sexually and can cause recurrent, painful genital ulcers. In neonates the infection is potentially lethal. We investigated the seroprevalence and correlates of HSV-2 infection in the United States and identified changes in HSV-2 seroprevalence since the late 1970s.
Abstract 1055: Character of tumor assocated protien recognized by monoclonal antibody against yunnan gejiu lung cancer
Authors: Qinqin Wang
Journal: Cancer Research (2010)

Abstract Character of tumor assocated protien recognized by monoclonal antibody against Yunnan Gejiu lung cancer: about protein N35 WANG Qinqin The Clinical Reseach Center. The First Hospital of Kunming Medial College Kunming, Yunnan, P.R. China 650032 ABSTRACT Objectives: To identify and characterize lung cancer associated protein N35 and attempt to learn the prospective possibility of the clinical application of the protein N35. Methods: Immunoprecipitation, immunoblotting, differential centrifigation and subcellular assay, immunohistochemistry, Nglycanase digestion, mitotic cell immunoflourescence and multiple methods of affinity chromatography have been used with the monoclonal antibody N-35 to detect the distribution of the protein N35 among the various cancer cell lines and normal human tissue, the relationship between the protein N35 and glycoprotein, the location of the subcellular structure and chromosomal domain of the protein N35,the most effective way of purification of tumor associated protein N35. Results: The protein N35 is a glycoprotein, distributes to the human lung cancer cell line GLC-82, human cervical cancer cell line Hela, human hepatic cancer cell line HepG-2 and human breast cancer cell line PMC with different relative molecular mass(Mr), but no expression of the protein ingredient in normal human fresh tissue; concentrates at the nuclei significantly, much more than at the mitochondrail and membrane, locates at the centriole of the chromosomal domain. Conclusions: The lung cancer associated protein N35 might be expressed only by the cancer cells and related with the proliferation of cancer cells as a role of tumor cell growth regulator. Keywords: Lung cancer cells, Tumor associated protein, Glycoprotein, Centriole Qinqin Wang Prof of The Clinical Reseach Center. The First Hospital of Kunming Medial College 295 Xichang Rd. 650032 Kunming Yunnan, P.R. China Tel:868714191985 Fax: 868715336015 Email: zys@public.km.yn.cn Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1055.
SAT0188 Early clinical improvement in SLE patients treated with belimumab:
Authors: A. Doria, J. Sanchez-Guerrero, D. Tegzová, E.M. Ginzler, Z.J. Zhong, G. Dennis, D.J. Wallace
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The belimumab BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) SLE trials utilized the SLE Responder Index (SRI) as the primary efficacy endpoint at wk 52. Increases in corticosteroid doses were allowed through wk 24. <h3>Objectives</h3> The effect of belimumab on improvement in disease activity during the 52-wk period was studied to assess the time that clinical benefit would be expected to occur. <h3>Methods</h3> Disease activity parameters were analyzed from pooled BLISS trial data to evaluate the effect of belimumab + standard therapy at wk 4, 8, and 12, and at or after wk 24 to determine the earliest time at which significant clinical improvement was observed. A ≥4-point SELENA-SLEDAI (SS) reduction was defined as clinically meaningful improvement. Clinical improvement was analyzed by determining odds ratios from logistic regression for comparisons between each belimumab dose and placebo (standard therapy alone) re SS reductions ≥4 thru 10, baseline (BL) scores ≤9 vs ≥10, and anti-double-stranded DNA (anti-dsDNA) positivity and hypocomplementemia at BL. Improvement in fatigue was assessed starting at wk 8 by FACIT-Fatigue using analysis of covariance for comparisons between each belimumab dose and placebo, adjusted for BL scores. Logistic regression was used for comparisons between each belimumab dose and placebo to assess steroid reduction. <h3>Results</h3> As early as 8-12 wk, significant disease activity improvement with SS reductions ≥4 was observed in the overall population, in patients with BL SS ≥10, and in those with anti-dsDNA positivity and hypocomplementemia (table). Significant SS reductions ≥7 occurred as early as 16 wk. <h3>Conclusions</h3> Belimumab treatment often resulted in clinically meaningful improvement with rapid reduction in disease activity in the first 3 mo. <h3>Disclosure of Interest</h3> A. Doria Consultant for: GlaxoSmithKline/Human Genome Sciences, Speakers Bureau: GlaxoSmithKline/Human Genome Sciences, J. Sanchez-Guerrero Consultant for: GlaxoSmithKline, D. Tegzová: None Declared, E. Ginzler Grant/Research support from: GlaxoSmithKline/Human Genome Sciences, Consultant for: GlaxoSmithKline/Human Genome Sciences, Z. Zhong Shareholder of: Human Genome Sciences, Employee of: Human Genome Sciences, G. Dennis Shareholder of: Human Genome Sciences, Employee of: Human Genome Sciences, D. Wallace Consultant for: GlaxoSmithKline/Human Genome Sciences, Speakers Bureau: GlaxoSmithKline/Human Genome Sciences
SAT0431 Inflammatory Ultrasound Features Show Strong and Independent Associations with Progression of Structural Damage after 2.5 Years of Follow-Up in Hand Osteoarthritis Patients
Authors: M. Kortekaas, W.Y. Kwok, M. Reijnierse, M. Kloppenburg
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Several cross sectional studies have shown that inflammatory ultrasound (US) features are frequently found in hand osteoarthritis (OA). Up till now, no follow up studies have been performed to study the natural evolution of inflammatory features and their association with structural damage. <h3>Objectives</h3> To investigate the development of inflammatory US features and it9s relation to structural damage over a 2.5 year period in 56 hand OA patients. <h3>Methods</h3> Synovial thickening, effusion and power Doppler signal (PDS) in DIP, PIP, 1st CMC, MCP and 1st IP joints were assessed using ultrasonography (US) in 56 consecutive hand OA patients (mean age 61.2 years, 86% female) fulfilling ACR classification criteria, at baseline and follow-up. Progression of osteophytes and joint space narrowing (JSN) was scored using the OARSI atlas. With generalized estimated equations odds ratios (OR) with 95% confidence intervals (CI) were calculated for the associations between inflammatory US features and radiographic progression taking in account patient effect, age, gender, BMI, baseline osteophytes and JSN scores, and other inflammatory US features. <h3>Results</h3> Of 1680 joints 8.4%, 8.7%, and 19.8% had synovial thickening, effusion or PDS at baseline, respectively, and 120 and 96 had progression of osteophytes and JSN, respectively. Independent associations were found between synovial thickening, effusion and PDS (grade 2-3 versus 0), and progression of osteophytes (OR (95%CI): 2.6 (1.02-6.5), 3.5 (1.7-7.4) and 5.7 (1.5-21.1)) and of JSN (OR (95%CI): 3.4 (1.3-8.4), 3.3 (1.5-7.6) and 3.1 (1.01-9.2)). Persistent inflammatory features at baseline and follow-up showed stronger associations with radiographic progression than fluctuating inflammatory features in comparison to no inflammatory features. <h3>Conclusions</h3> Inflammatory US features, especially when persistently present, are independently associated with radiographic progression in hand OA after 2.5 years, indicating a role of inflammation in the aetiology of structural damage in hand OA. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2734
Court-Ordered Cesarean Sections Receive Judicial Defeat
Authors: William J. Curran
Journal: New England Journal of Medicine (1990)

In a quiet, often unnoticed, but consistent manner, a number of trial-court judges in at least 11 states across the country have ordered that a pregnant woman must submit to a cesarean section to deliver a viable fetus against the known and clearly expressed will of the woman. This legal intervention has virtually always been brought about by the same physicians who were caring for the woman during her pregnancy. As one legal commentator has observed, "In most cases that have been brought, doctors have prevailed easily."1 In what is still the only nationwide survey of court orders sought by . . .
The Midterm Elections — High Stakes for Health Policy
Authors: Henry J. Aaron
Journal: New England Journal of Medicine (2010)

The stakes for health policy in the 2010 congressional elections are higher than they have ever been. The political parties are polarized. Policy divisions are deep. The challenges of implementingthe Affordable Care Act (ACA) are enormous. The outcome of the 2010 congressional elections may well determine whether this landmark legislation succeeds or fails. Whatever the electoral outcome, the political battle over health care reform will continue into the 2012 presidential elections and probably beyond.The evidence of party polarization is overwhelming (see table).1 A majority of both parties ended up voting for the original Social Security Act, although Republicans had . . .
Abstract 5118: Comparative study on feature selection methods in ovarian cancer diagnosis using chemometrics tools
Authors: Seongkyu Yoon, Hae Woo Lee, Jay Liu, Young Jung Na
Journal: Cancer Research (2011)

Abstract Ovarian cancer has the poorest prognosis of the gynecological cancers. 75% of the patients are diagnosed with stage III-IV on their diagnosis. The 5 year survival rate of ovarian cancer patients whose disease was diagnosed at stage III or IV is less than 20%, but that of the patients diagnosed with stage I is higher than 90%. The early detection and diagnosis of cancer is one of the major application areas in omics technology and has received tremendous attention in last few years. The main focus of this study is aimed at the investigation of robust formulations for the feature selection algorithms which are utilized during the statistical analysis of omics profiles in diagnosing ovarian cancer. The common difficulty in the feature selection for cancer-specific biomarker discovery is the inconsistency of the feature sets selected among different samples or by different selection methods. This issue is particularly crucial in biological applications where subsequent biomedical analysis of selected features requires relatively considerable time and costs. In this study, we analyzed the reproducibility of different feature selection algorithms usually employed in chemometrics and investigated their stability to provide valuable insight for designing proper feature selection algorithms in the domain of cancer-specific biomarker discovery. Two data sets of MALDI-TOF-MS (proteomics) and LC/TOF-MS (metabolomics) spectra measured from serum samples to diagnose ovarian cancer were analyzed. To evaluate the feature selection methods in terms of their consistency, we systematically quantified a measure of similarity (similarity≤1) for the outcome of each method by running each selection procedures repetitively. The results show that, in general, the multivariate feature selection methods outperformed the univariate methods, in that they selected more consistent features regardless of training set perturbations. The results clearly show that some feature selection methods can suffer severely from the irreproducibility issue and this might deflate the potential benefits of omics technology for cancer diagnosis. A possible remedy might be multi-objective formulation of the feature selection problem by simultaneously optimizing stability and accuracy of classification models, and this will be investigated further in future research. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5118. doi:10.1158/1538-7445.AM2011-5118
Abstract 5411: Rb1 controls the differentiation of myeloid-derived suppressor cells subsets
Authors: Je-In Youn, Michelle Collazo, Vinit Kumar, Dmitry I. Gabrilovich
Journal: Cancer Research (2012)

Abstract Myeloid derived suppressor cells (MDSC) consist of two distinct subsets, polymorphonuclear/granulocytic-MDSC (PMN-MDSC), and monocytic-MDSC (M-MDSC) that differ in morphology, phenotype and preferred suppression mechanisms. PMN-MDSC is the predominant subset of MDSC that accumulates in spleen, bone marrow, blood, and tumor tissues in various mouse tumor models. M-MDSC produced higher level of cytokines and chemokines including G-CSF, IL-1b, IL-6, TNF-a, MCP-1 and RANTES compared to PMN-MDSC. The current paradigm considers PMN-MDSC and M-MDSC to differentiate from different progenitors alongside different lineages (granulocytic and monocytic, respectively). M-MDSC differentiate into dendritic cells and macrophages, whereas PMN-MDSC are terminally differentiated cells. Our study demonstrated that in cancer M-MDSC represent highly proliferative population of cells that differentiate not only to DC and macrophages but also to PMN-MDSC. The retinoblastoma gene (Rb1), a central regulator of the cell cycle and cell differentiation, is known to be involved in monocytic and granulocytic lineage commitment. When examining Rb1 levels in freshly isolated cells, M-MDSC expressed high levels of Rb1 similar to those in dendritic cells, macrophages, and neutrophils isolated from naïve mice. In sharp contrast, PMN-MDSC had undetectable Rb1. Lack of Rb1 in mice with conditional deletion of the gene promoted an expansion of splenic CD11b+Ly6G+Ly6Clo cells, similar to the phenotype of PMN-MDSC in tumor-bearing mice. Lack of Rb1 in PMN-MDSC was caused by transcriptional repression of the gene. In culture with GM-CSF, Rb1 expression in M-MDSC remained the same while in PMN-MDSC it was increased over time to the level seen in control neutrophils. Inhibition of rb1 expression in PMN-MDSC correlated with the level of histone acetylation of rb1 promoter. Treatment of PMN-MDSC with inhibitors of histone deacetilases (HDAC) resulted in the increase in rb1 expression suggesting that it may be controlled by histone modification. HDAC inhibitors abrogated differentiation of M-MDSC to PMN-MDSC in the presence of tumor explants conditioned medium. These results suggest that down-regulation of Rb1 plays a major role in accumulation of MDSC in cancer by regulating PMN-MDSC differentiation from M-MDSC. HDAC may be considered as potential targets for therapeutic regulation of MDSC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5411. doi:1538-7445.AM2012-5411
PROGNOSTIC IMPACT OF AGE AND SEX ADJUSTED B-TYPE NATRIURETIC PEPTIDE UPON CLINICAL OUTCOME IN PATIENTS WITH ORGANIC MITRAL REGURGITATION
Authors: Marie-Annick Clavel, Christophe Tribouilloy, Jean-Louis Vanoverschelde, Rodolfo Pizarro, Rakesh Suri, Catherine Szymanski, Siham Lazam, Maurice Enriquez-Sarano
Journal: Journal of the American College of Cardiology (2015)
BLOCKADE OF CHEMOKINE: GLYCOSAMINOGLYCAN (GAG) (GLYCOCALYX) BINDING IN THE RENAL DONOR ORGAN SIGNIFICANTLY REDUCES TRANSPLANT REJECTION AND VASCULAR INFLAMMATION
Authors: Alexandra R. Lucas, Sriram Ambadapadi, Hao Chen, Donghang Zheng, Dara Wakefield, William Clapp
Journal: Journal of the American College of Cardiology (2015)
[Significance of Various Type Chromosome Aberrations for Man]: Discussion
Authors: G. Wolff, Warren W. Nichols, M. S. Legator, W. G. Flamm, J. F. Crow, S. S. Epstein, S. Abrahamson, V. A. Ray, M. Shaw, E. Freese, Dr. Mauer, B. Ames, L. Friedman
Journal: Environmental Health Perspectives (1973)
<i>Entamoeba histolytica</i>as a Commensal Intestinal Parasite in Homosexual Men
Authors: Erica Allason-Jones, Adrian Mindel, Peter Sargeaunt, Peter Williams
Journal: New England Journal of Medicine (1986)

Entamoeba histolytica is considered to be an uncommon, imported organism in the United Kingdom and in many parts of North America, but recent attention has been drawn to the possibility of sexual transmission of this parasite among homosexual men. To determine the prevalence and clinical importance of enteric parasitic infections in men attending a clinic in London for the treatment of sexually transmitted diseases, we studied 354 randomly selected patients who provided a single stool sample that was examined for E. histolytica and other intestinal parasites. Forty-five of the 225 homosexual patients (20 percent) were infected with E. histolytica, but no such infections were found among the 129 heterosexual subjects (P less than 0.0001). With the use of isoenzyme electrophoresis, 34 of the 45 E. histolytica isolates were classified according to zymodeme. All were Zymodeme I or III, which are considered to be nonpathogenic. There was no correlation between the presence of E. histolytica and gastrointestinal symptoms. These findings suggest that E. histolytica is a common commensal in the homosexual population and that, in the absence of evidence of invasive disease, treatment of persons passing cysts of the organism may have little practical benefit.