tbuckley/cabot-search huggingface dataset:
Dependent personality disorder associated with phobic avoidance in patients with panic disorder
Authors: J Reich, R Noyes, E Troughton
Journal: American Journal of Psychiatry (1987)

Eighty-eight panic disorder patients were divided into three groups according to the extent of their phobic avoidance (none, limited, or extensive). These groups were compared on three personality disorder instruments: the Structured Interview for DSM-III Personality Disorders, the Personality Diagnostic Questionnaire, and the Millon Clinical Multiaxial Inventory. Phobic patients were found to have significantly more dependent personality disorder and DSM-III third-cluster personality disorders than nonphobic patients. A subgroup of patients with social phobic symptoms was found to resemble the rest of the phobic group in terms of personality.
Dysregulation of EGFR Pathway in EphA2 Cell Subpopulation Significantly Associates with Poor Prognosis in Colorectal Cancer
Authors: Mariangela De Robertis, Luisa Loiacono, Caterina Fusilli, Maria Luana Poeta, Tommaso Mazza, Massimo Sanchez, Luigi Marchionni, Emanuela Signori, Giuseppe Lamorte, Angelo Luigi Vescovi, Jesus Garcia-Foncillas, Vito Michele Fazio
Journal: Clinical Cancer Research (2016)

Abstract Purpose: EphA2 receptor is involved in multiple cross-talks with other cellular networks, including EGFR, FAK, and VEGF pathways, with which it collaborates to stimulate cell migration, invasion, and metastasis. Colorectal cancer (CRC) EphA2 overexpression has also been correlated to stem-like properties of cells and tumor malignancy. We investigated the molecular cross-talk and miRNAs modulation of the EphA2 and EGFR pathways. We also explored the role of EphA2/EGFR pathway mediators as prognostic factors or predictors of cetuximab benefit in patients with CRC. Experimental Design: Gene expression analysis was performed in EphA2high cells isolated from CRC of the AOM/DSS murine model by FACS-assisted procedures. Six independent cohorts of patients were stratified by EphA2 expression to determine the potential prognostic role of a EphA2/EGFR signature and its effect on cetuximab treatment response. Results: We identified a gene expression pattern (EphA2, Efna1, Egfr, Ptpn12, and Atf2) reflecting the activation of EphA2 and EGFR pathways and a coherent dysregulation of mir-26b and mir-200a. Such a pattern showed prognostic significance in patients with stage I–III CRC, in both univariate and multivariate analysis. In patients with stage IV and WT KRAS, EphA2/Efna1/Egfr gene expression status was significantly associated with poor response to cetuximab treatment. Furthermore, EphA2 and EGFR overexpression showed a combined effect relative to cetuximab resistance, independently from KRAS mutation status. Conclusions: These results suggest that EphA2/Efna1/Egfr genes, linked to a possible control by miR-200a and miR-26b, could be proposed as novel CRC prognostic biomarkers. Moreover, EphA2 could be linked to a mechanism of resistance to cetuximab alternative to KRAS mutations. Clin Cancer Res; 23(1); 159–70. ©2016 AACR.
Bovine Serum Albulmin Protein‐Templated Silver Nanocluster (BSA‐Ag<sub>13</sub>): An Effective Singlet Oxygen Generator for Photodynamic Cancer Therapy
Authors: Yong Yu, Junlong Geng, Edward Yong Xi Ong, Vijila Chellappan, Yen Nee Tan
Journal: Advanced Healthcare Materials (2016)

This paper reports a novel synthesis approach of bovine serum albumin (BSA) protein-templated ultrasmall (<2 nm) Ag nanocluster (NC) with strong singlet oxygen generation capacity for photodynamic therapy (PDT). An atomically precise BSA-Ag13 NC (i.e., 13 Ag atoms per cluster) is successfully synthesized for the first time by using NaOH-dissolved NaBH4 solution as the controlling reducing agent. The ubiquitous size of BSA-Ag13 NC results in unique behaviors of its photoexcited states as characterized by the ultrafast laser spectroscopy using time-correlated single photon counting and transient absorption techniques. In particular, triply excited states can be largely present in the excited BSA-Ag13 NC and readily sensitized molecular oxygen to produce singlet oxygen (1 O2 ) with a high quantum efficiency (≈1.26 using Rose Bengal as a standard). This value is much higher than its Au analogue (i.e., ≈0.07 for BSA-Au25 NC) and the commonly available photosensitizers. Due to the good cellular uptake and inherent biocompatibility imparted by the surface protein, BSA-Ag13 NC can be applied as an effective PDT agent in generating 1 O2 to kill cancer cell as demonstrated in this study.
Ovarian function suppression is beneficial in some premenopausal women with early breast cancer
Authors: Mary Kay Barton
Journal: CA A Cancer Journal for Clinicians (2016)

Key Points Premenopausal women with HR‐positive early breast cancer benefit from exemestane plus OFS versus tamoxifen with or without OFS. Results of SOFT and TEXT support the addition of OFS to exemestane or tamoxifen in premenopausal women whose risk of recurrence warrants (neo)adjuvant chemotherapy. Women with low‐risk early breast cancer derive minimal benefit from the addition of OFS.
Incorporation of the Bone Marker Carboxy-Terminal Telopeptide of Type-1 Collagen (ICTP) into a Combined ISS-ICTP Score Improves the Prognostic Significance of the ISS in Newly Diagnosed Symptomatic Multiple Myeloma and Identifies a Very Low Risk Group Which Has No Benefit from High-Dose Therapy
Authors: Christian Jakob, Peter Liebisch, Ulrike Heider, Martin Kaiser, Jan Sterz, Jessica Rademacher, Claudia Fleissner, Christian Müller, Orhan Sezer
Journal: Blood (2008)
Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
Authors: Jesse M. Zaretsky, Angel Garcia-Diaz, Daniel S. Shin, Helena Escuin-Ordinas, Willy Hugo, Siwen Hu-Lieskovan, Davis Y. Torrejon, Gabriel Abril-Rodriguez, Salemiz Sandoval, Lucas Barthly, Justin Saco, Blanca Homet Moreno, Riccardo Mezzadra, Bartosz Chmielowski, Kathleen Ruchalski, I. Peter Shintaku, Phillip J. Sanchez, Cristina Puig-Saus, Grace Cherry, Elizabeth Seja, Xiangju Kong, Jia Pang, Beata Berent-Maoz, Begoña Comin-Anduix, Thomas G. Graeber, Paul C. Tumeh, Ton N.M. Schumacher, Roger S. Lo, Antoni Ribas
Journal: New England Journal of Medicine (2016)

Approximately 75% of objective responses to anti–programmed death 1 (PD-1) therapy in patients with melanoma are durable, lasting for years, but delayed relapses have been noted long after initial objective tumor regression despite continuous therapy. Mechanisms of immune escape in this context are unknown.
Case 47-1989
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Paul A. Boepple, Robert H. Young
Journal: New England Journal of Medicine (1989)

Presentation of CaseA 6 1/2-year-old black girl was admitted to the hospital because of sexual precocity.The girl was born by a vaginal delivery after a fullterm third pregnancy to a mother 28 years old; the pregnancy was complicated by attacks of pain secondary to sickle–hemoglobin C disease. The pain required the administration of oxygen in emergency rooms. Delivery was uncomplicated, and the child's birth weight was 3.4 kg. Her early growth and development were normal; she walked at one year of age. Two and a half weeks before entry vaginal bleeding was noted. A physician found no evidence . . .
A comparison of two methods of diagnosing hysteria
Authors: R Kimble, J G Williams, S Agras
Journal: American Journal of Psychiatry (1975)

The authors compare the syndrome of hysteria, defined as or indicated by a specified response to a 55-item symptom checklist previously used by Guze and other researchers, with the definition of hysterical personality in the second edition of APA's Diagnostic and statistical Manual of Mental Disorders (DSM-II). When 20 control subjects and 10 hysterical personalities (DSM-II) were given the Perley-Guze test, the results showed a close correlation between positive scores on the symptom checklist and the DMS-II diagnosis. The authors comment briefly on the theoretical usefulness and practicality of the test and note some difficulties in administration.
P-051 Preliminary clinical and pathologic characteristics of patients treated in second-line (2L) with 25 cycles (Cy) or more of FOLFIRI + Aflibercept (FA)
Authors: C. Pericay, N. Martínez-Lago, M. Corral, I. Macías Declara, O. Donnay, I. Juez Martel, B. García-Paredes, J.C. Méndez Méndez, D. Cacho Lanvin, B. González-Astorga, A. Ruiz Casado, M.T. Delgado Ureña, N. Rodriguez, V. Calderero Aragón, E. Mata Velasco, J.A. Barrera Ramírez, T. Macarulla
Journal: Annals of Oncology (2016)
Thoughts from a journey.
Authors: B Fisher
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.12.2297 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8246019 Thoughts from a journey. B FisherxB FisherSearch for articles by this author Show More University of Pittsburgh School of Medicine, PA 15261. https://doi.org/10.1200/JCO.1993.11.12.2297 First Page PDF © 1993 by American Society of Clinical Oncology
Endocytosis Mechanism of Nano Metal‐Organic Frameworks for Drug Delivery
Authors: Claudia Orellana‐Tavra, Sergio A. Mercado, David Fairen‐Jimenez
Journal: Advanced Healthcare Materials (2016)

The pathway of internalization and final fate of a specific metal-organic framework (MOF) in cells has been investigated for the first time. This study is based on two calcein-loaded UiO-66 samples with particle sizes of 150 and 260 nm (i.e., cal@150 UiO-66 and cal@260 UiO-66, respectively), and shows that the active trafficking of cal@150 UiO-66 is done almost exclusively through clathrin-mediated endocytosis, whereas the uptake of cal@260 UiO-66 is a combination of both clathrin and caveolae-mediated endocytosis. Colocalization studies with a lysosomal marker showed that cal@150 UiO-66 is located mostly in lysosomes for further degradation, whereas cal@260 UiO-66 seems to avoid the lysosomal degradation and potentially deliver the cargo molecules in the cytosol, allowing their distribution to different cellular organelles. This study reveals the importance of the internalization processes of MOFs, particularly the relevance of their particle size, and also the critical significance of their final fate to become an efficient drug delivery system. Based on these results, it is possible that extremely small particle-sized MOFs are not the most efficient carriers and instead relatively medium-sized particles are required.
The Past and Future of the Affordable Care Act
Authors: Jonathan Skinner, Amitabh Chandra
Journal: JAMA (2016)

But he also stresses the lesson of appreciating pragmatism in legislation and implementation.That is a good lesson, yet it does not contradict the importance of also being guided by philosophical principle.If it were a separate economy, the US health system would be equivalent to the fifth or sixth largest economy in the world.It is both pragmatic and principled to recognize that achieving agreement on how to redesign an economy that large, or to do it successfully in 1 piece of legislation, is beyond the capabilities of the federal government.That is why core parts of the ACA need to be reassessed and revised and why empowering the US system of federalism to adapt and experiment with the law is so important.
Local Anesthesia
Authors: Benjamin G. Covino
Journal: New England Journal of Medicine (1972)

LOCAL anesthesia is defined as a loss of feeling or sensation that is confined to a circumscribed area of the body. This loss of sensation most commonly results from an inhibition of the conduction process in peripheral nervous tissue. Nerve conduction can be altered by many different means – e.g., mechanical trauma, low temperature, anoxia and a variety of chemical irritants such as alcohol or phenol. In clinical practice pharmacologic agents usually employed produce a transient and completely reversible state of anesthesia in the area where loss of sensation is desired.Local-anesthetic agents differ considerably from most other classes of . . .
The Concomitant High Expression of the B-Cell Receptor Signaling Inhibitor Molecules CD150, CD305, and CD307b Predicts Longer Overall Survival in the Context of Low-Risk Chronic Lymphocytic Leukemia
Authors: Antonella Zucchetto, Dania Benedetti, Chiara Caldana, Erika Tissino, Michele Dal Bo, Pietro Bulian, Riccardo Bomben, Francesca Rossi, Francesco Zaja, Gabriele Pozzato, Annalisa Chiarenza, Francesco Di Raimondo, Giovanni Del Poeta, Valter Gattei
Journal: Blood (2015)
Review: Evidence is insufficient to determine the risk–benefit ratio for vision acuity screening in older adults
Authors: Terry Quinn
Journal: Annals of Internal Medicine (2016)

Source Citation Chou R, Dana T, Bougatsos C, Grusing S, Blazina I. Screening for impaired visual acuity in older adults: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2016;315:915-33. 26934261
Does Allogeneic Hematopoietic Cell Transplantation Benefit Older (≥ 60) AML/MDS Patients With Monosomal Karyotype?
Authors: James L Slack, Nandita Khera, Veena Fauble, Jose F Leis, Lisa Sproat, Jared Klein, Craig B. Reeder, Jeffrey A Betcher, Pierre Noel
Journal: Blood (2013)
Abstract 2439: Clinical Profile and Risk of Sudden Death in Children with Timothy Syndrome
Authors: Raffaella Bloise, Carlo Napolitano, Katherine W Timothy, Denise Pontes Cavalcanti, Eszter Szepesvary, Fabrizio Drago, Janni Nastoli, Igor Splawski, Mark T Keating, Silvia G Priori
Journal: Circulation (2006)

Timothy Syndrome (TS) is the most malignant form of Long QT Syndrome (LQTS): patients (pts) have the LQTS cardiac phenotype and multisystem disorders such as neuropsychiatric manifestations, syndactyly, immune system dysfunction, hypoglicemia and cardiac malformations. TS is caused by a single mutation (G406R) in the CACNA1C gene encoding the cardiac voltage-gated calcium channel (Cav1.2). We report here clinical data on the largest series of TS patients (22 patients from 24 families) derived from our TS Registry. Data were available since birth and the mean age at last contact was 6 + 6 years. Genetic diagnosis was available in 16/24 pts while for 8 pts DNA could not be obtained. The ECG showed a mean QTc of 600 msec (range 510 –700 msec); 13 patients had a QTc > 600 msec; functional 2:1 AV block was present in 18 pts and macroscopic T wave alternans in 7 pts. Sustained ventricular tachyarrhythmias occurred in 19/24 (79%) pts. Congenital heart disease was diagnosed in 55%. Hand/feet syndactyly was present in all patients, facial dysmorphisms in 91%, sepsis occurred in 50% (9/18) and neuropsychiatric disorders in 83%. Response to antiarrhythmic therapy is reported in the table. In 3 families multiple children were affected despite parents did not carry the G406R CACNA1C mutation in genomic DNA: in 2 cases the mutation was identified in DNA extracted from tissues (somatic mutation), in the third case prenatal diagnosis identified the mutation in the fetus.  In conclusion:  Timothy syndrome is a rare, highly malignant disease that mandates an aggressive management  SCD occurs at very young age despite betablockers even when combined with PM and/or LSGx  death occurs not only for cardiac arrhythmias but also for extracardiac conditions that should therefore be carefully monitored  transmission through somatic mutations warrants careful genetic counseling for TS families.
Risk of progression for incidental small subepithelial tumors in the upper gastrointestinal tract
Authors: Ji Song, Sang Kim, Su Chung, Hae Kang, Sun Yang, Young Kim
Journal: Endoscopy (2015)

<b>Background and study aims:</b> Subepithelial tumor is a relatively common finding in upper gastrointestinal endoscopy. This study aimed to evaluate the natural course of incidentally detected small subepithelial tumors in the upper gastrointestinal tract and to analyze risk factors for increase in the size of such tumors. <b>Patients and methods:</b> Medical records of 1684 patients with subepithelial tumors in the upper gastrointestinal tract incidentally detected between 2004 and 2013 were retrospectively reviewed. If serial follow-up endoscopy showed significant size increase, endoscopic or surgical resection was recommended because of possibility of malignant change. <b>Results:</b> 954 participants with subepithelial tumors underwent serial upper gastrointestinal endoscopy for a period > 6 months. Initial mean size of subepithelial tumors was 8.7 mm (range 1 – 35 mm). During a mean follow-up of 47.3 months (range 6 – 118 months), lesion size was unchanged in 920 participants (96.4 %), and in 34 participants (3.6 %) lesions had increased at least 25 % in diameter (mean increment 6.2 mm, range 2 – 15 mm). Subepithelial tumors with overlying mucosal changes (hyperemia, erosion, or ulcer) had a significantly higher risk of increasing in size (odds ratio [OR] = 3.61, 95 % confidence interval [95 %CI] 1.06 – 12.28). Growth rates (size increment per year) for enlarging lesions were significantly correlated with initial size (<i>r</i> = 0.44, <i>P</i> = 0.009). <b>Conclusions:</b> Most incidentally detected small subepithelial tumors in the upper gastrointestinal tract showed no size change during follow-up. Thus, regular follow-up with serial endoscopy may be sufficient for small subepithelial tumors (< 2 cm) with intact overlying mucosa.
European Society of Cardiology Heart Failure Long‐Term Registry (<scp>ESC‐HF‐LT</scp>): 1‐year follow‐up outcomes and differences across regions
Authors: Maria G. Crespo‐Leiro, Stefan D. Anker, Aldo P. Maggioni, Andrew J. Coats, Gerasimos Filippatos, Frank Ruschitzka, Roberto Ferrari, Massimo Francesco Piepoli, Juan F. Delgado Jimenez, Marco Metra, Candida Fonseca, Jaromir Hradec, Offer Amir, Damien Logeart, Ulf Dahlström, Bela Merkely, Jaroslaw Drozdz, Eva Goncalvesova, Mahmoud Hassanein, Ovidiu Chioncel, Mitja Lainscak, Petar M. Seferovic, Dimitris Tousoulis, Ausra Kavoliuniene, Friedrich Fruhwald, Emir Fazlibegovic, Ahmet Temizhan, Plamen Gatzov, Andrejs Erglis, Cécile Laroche, Alexandre Mebazaa
Journal: European Journal of Heart Failure (2016)
Mutant Chlamydia trachomatis in Denmark
Authors: S Hoffmann, J S Jensen
Journal: Eurosurveillance (2007)

A mutant Chlamydia trachomatis variant was detected in Sweden in 2006 and has since also been diagnosed in Norway, but not in Ireland or the Netherlands. This paper describes a study aimed at assessing the presence of the new variant in Denmark. Between November 2006 and April 2007 we tested 3,770 specimens using methods capable of detecting the new variant and distinguishing it from the wild type. In late March 2007 we found one case of the new variant in a 19-year old Danish woman without any known relationship to Sweden. It is surprising that the spread of this sexually transmitted pathogen into Denmark and within Denmark has been so low in view of its rapid and substantial spread within Sweden.
Myocardial ischemia and infarction associated with vinorelbine.
Authors: A Bergeron, O Raffy, J M Vannetzel
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.2.531 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7844615 Myocardial ischemia and infarction associated with vinorelbine. A BergeronxA BergeronSearch for articles by this author , O RaffyxO RaffySearch for articles by this author , J M VannetzelxJ M VannetzelSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.2.531 PDF "Myocardial ischemia and infarction associated with vinorelbine.." Journal of Clinical Oncology, 13(2), pp. 531–532© 1995 by American Society of Clinical Oncology
Partial Wolfram syndrome (DIDMOAD): two new patients in a family. Diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.
Authors: A Hernandez-Mijares, C Morillas, None Lluch, M L Martinez-Triguero, M L Muñoz, M Gomez, M A Merino, M Escudero
Journal: Diabetes Care (1999)
Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance
Authors: Sunjae Lee, Cheng Zhang, Murat Kilicarslan, Brian D. Piening, Elias Bjornson, Björn M. Hallström, Albert K. Groen, Ele Ferrannini, Markku Laakso, Michael Snyder, Matthias Blüher, Mathias Uhlen, Jens Nielsen, Ulf Smith, Mireille J. Serlie, Jan Boren, Adil Mardinoglu
Journal: Cell Metabolism (2016)
Vemurafenib‐induced granulomatous hepatitis
Authors: Erin K. Spengler, David E. Kleiner, Robert J. Fontana
Journal: Hepatology (2016)

Vemurafenib (Zelboraf; Genentech, CA) is a highly effective oral chemotherapy agent for patients with metastatic melanoma who carry the BRAF V600E mutation. Side effects of this protein kinase inhibitor (PKI) include arthralgia, rash, and fatigue, which are reported in up to one third of treated patients. Mild abnormalities in liver biochemistries were reported with vemurafenib use in 30% of subjects, 11% developed severe laboratory abnormalities, and acute liver failure has been reported (Table ). Herein, a case of severe vemurafenib-induced granulomatous hepatitis leading to chronic cholestasis is reported along with a review of the hepatotoxicity of other PKIs.
Selective and Efficient Gene Delivery of CD40-Ligand by a Fiber-Modified Adenovirus Vector with Specific Antibody to Human Leukemia and Myeloma.
Authors: Kazunori Kato, Sachie Hirai, Yukari Masuta, Aiko Kuroishi, Kiminori Nakamura, Hirofumi Hamada
Journal: Blood (2004)
Repeated Administrations of Cardiac Progenitor Cells Are Markedly More Effective Than a Single Administration
Authors: Yukichi Tokita, Xian-Liang Tang, Qianhong Li, Marcin Wysoczynski, Kyung U. Hong, Shunichi Nakamura, Wen-Jian Wu, Wei Xie, Ding Li, Greg Hunt, Qinghui Ou, Heather Stowers, Roberto Bolli
Journal: Circulation Research (2016)

The effects of c-kit(POS) cardiac progenitor cells (CPCs, and adult cell therapy in general) on left ventricular (LV) function have been regarded as modest or inconsistent.To determine whether 3 CPC infusions have greater efficacy than 1 infusion.Rats with a 30-day-old myocardial infarction received 1 or 3 CPC infusions into the LV cavity, 35 days apart. Compared with vehicle-treated rats, the single-dose group exhibited improved LV function after the first infusion (consisting of CPCs) but not after the second and third (vehicle). In contrast, in the multiple-dose group, regional and global LV function improved by a similar degree after each CPC infusion, resulting in greater cumulative effects. For example, the total increase in LV ejection fraction was approximately triple in the multiple-dose group versus the single-dose group (P<0.01). The multiple-dose group also exhibited more viable tissue and less scar, less collagen in the risk and noninfarcted regions, and greater myocyte density in the risk region.This is the first demonstration that repeated CPC administrations are markedly more effective than a single administration. The concept that the full effects of CPCs require repeated doses has significant implications for both preclinical and clinical studies; it suggests that the benefits of cell therapy may be underestimated or even overlooked if they are measured after a single dose, and that repeated administrations are necessary to evaluate the effectiveness of a cell product properly. In addition, we describe a new method that enables studies of repeated cell administrations in rodents.