tbuckley/cabot-search huggingface dataset:
Abstract 19363: Prevention of Progressive Worsening of Heart Failure Over Time With The Angiotensin-receptor Neprilysin Inhibitor Sacubitril/valsartan (lcz696)
Authors: John McMurray, Pardeep Jhund, Jianjian Gong, Jean Rouleau, Martin Lefkowitz, Akshay Desai, Adel Rizkala, Victor Shi, Karl Swedberg, Michael Zile, Scott Solomon, Milton Packer
Journal: Circulation (2015)

Background: The aim of this analysis was to examine the effect of the angiotensin receptor neprilysin inhibitor (ARNI) sacubitril/valsartan (LCZ696), compared with enalapril, on progressive worsening over time in patients with heart failure and reduced ejection fraction (HF-REF) enrolled in the Prospective comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidly in Heart Failure trial (PARADIGM-HF). Methods: In PARADIGM-HF, 4212 patients were randomized to enalapril and 4187 to sacubitril/valsartan. The primary outcome was the composite of cardiovascular (CV) death or hospitalization for heart failure (HF). To make a more comprehensive evaluation of HF worsening over time, we analysed the broader composite of CV death, HF hospitalization, emergency department visit for HF or intensification of therapy for HF (as time-to-first event) using the Kaplan-Meier (KM) method. Results: At baseline, 71% of patients were in NYHA functional class II and 24% in class III. Their mean LVEF was 27% and 93% were treated with a beta-blocker and 56% with a mineralocorticoid receptor antagonist. The median duration of follow-up was 27 months. The 1, 2 and 3 year KM rates for the composite outcome in the enalapril group were 16.5 (95% CI 15.5, 17.7)%, 27.6 (26.2, 29.1) and 34.8 (33.1-36.6)%, respectively. The corresponding rates in the sacubitril/valsartan group were 13.4 (12.4, 14.5), 22.1 (20.8, 23.4) and 29.5 (27.9, 31.2)%, respectively. Overall 1275 enalapril treated and 1038 sacubitril/valsartan treated patients had an event, giving a hazard ratio 0.79 (95% CI 0.73, 0.86), p&lt;0.0001. Over the course of the trial, 55 fewer patients per 1000 treated with sacubitril/valsartan, compared with enalapril, experienced worsening (number needed to treat = 18). Conclusions: Even in patients with predominantly mild symptoms, well treated with evidence-based pharmacological therapy, worsening of HF over time was common, with more than a third of patients exhibiting progression within 3 years. The ARNI sacubitril/valsartan led to clinically important relative and absolute reductions in progressive worsening, compared with enalapril.
EFICACIA Y SEGURIDAD DE LA NOTES MEDIASTÍNICA: RESULTADOS PRELIMINARES DE UN ESTUDIO PROSPECTIVO ALEATORIZADO
Authors: H Córdova, A Rodríguez-D'Jesús, R Navarro-Ripoll, G Martínez-Pallí, C Rodríguez de Miguel, M Beltrán, M Cuatrecasas, JM Gimferrer, M Boada, J Llach, G Fernández-Esparrach
Journal: Endoscopy (2011)

Introducción: A través del esófago, es posible acceder al mediastino sin incisiones en la pared torácica. La mediastinoscopia transesofágica estaría especialmente indicada en pacientes portadores de traqueostomía o con rigidez cervical en los que la mediastinoscopia estándar se asocia a más morbilidad.
Radioimmunoassay for Myeloma ldiotype 2
Authors: S. Gailani, B. K. Seon, A. Nussbaum, E. S. Henderson, D. Pressman
Journal: JNCI Journal of the National Cancer Institute (1977)

Rabbit anti-idiotype antisera were prepared against four human myeloma proteins. These antisera demonstrated a capacity to bind the 125I-labeled autologous purified monoclonal IgG, but failed to demonstrate any binding to 125I-labeled normal IgG or to labeled myeloma IgG obtained from other myeloma patients. The anti-idiotypic antisera were used with 125I-labeled autologous myeloma IgG preparations and goat antirabbit IgG for specific radioimmunoassay with a sensitivity limit of 20 ng/ml. Little or no cross-reaction occurred between these anti-idiotypic antisera and normal IgG preparations or other myeloma IgG proteins.
PROGRESSIVE HYPONATREMIA DURING HEART FAILURE TREATMENT PROVIDES THE LONG-TERM PROGNOSTIC INFORMATION IN PATIENTS ADMITTED WITH ACUTE DECOMPENSATED HEART FAILURE, REGARDLESS OF REDUCED OR PRESERVED LEFT VENTRICULAR EJECTION FRACTION
Authors: Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Shunsuke Tamaki, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tatsuhisa Ozaki, Masahiro Seo, Yoshihiro Sato, Iyo Ikeda, Eiji Fukuhara, Masatake Fukunami
Journal: Journal of the American College of Cardiology (2016)
A Higher Order Parsimony Method to Reduce Long-Branch Attraction
Authors: S. J. Willson
Journal: Molecular Biology and Evolution (1999)

Results are presented for the problem of reconstructing a phylogenetic tree for a quartet of four species from DNA strings for the species.For quartets, a notion of order of approximation is defined.It is shown that choosing the topology for a given quartet by maximum parsimony (MP) is of order 2. A new method of order 3 is described.This method, called higher order parsimony (HOP), gives improved results on artificial data of nucleotides, greatly reducing the effect of long-branch attraction.Comparisons are made with MP, maximum likelihood (ML), and Hadamard conjugation on many artificial data sets chosen such that long-branch attraction would be a problem.Both HOP and ML are much more accurate than MP.The accuracies of HOP and ML appear comparable, with ML somewhat more accurate when the model used to generate substitutions closely matches that assumed by ML, and transitions dominate over transversions.When the model for substitutions differs substantially from that assumed by ML, then HOP may outperform ML, suggesting that HOP is more model-independent.The required computer time for HOP is, moreover, much shorter than that for ML, giving HOP a major practical advantage.HOP works best when the alphabet corresponds to sequences of nucleotides; hence, a modification is also presented that applies when the alphabet corresponds to amino acid residues.
Abstract PD06-01: A Single Treatment with Targeted Intraoperative Radiotherapy (TARGIT) Is Similar to Several Weeks of External Beam Radiotherapy (EBRT) with Respect to Efficacy and Safety, and Has Obvious Advantages to the Patient and the Economy
Authors: JS Vaidya, DJ Joseph, JS Tobias, FK Wenz, M Bulsara, M Alvarado, MR Keshtgar, W Eiermann, NR Williams, M, Baum
Journal: Cancer Research (2010)

Abstract Background: After breast-conserving surgery, 90% of local recurrences occur within the index quadrant despite the presence of multicentric cancers elsewhere in the breast. Thus, restriction of radiation therapy to the tumour bed during surgery might be adequate for selected patients. Materials and methods: Having safely piloted the new technique of single-dose targeted intraoperative radiotherapy (TARGIT) with Intrabeam, we launched the TARGIT-A trial on March 24, 2000. In this prospective, randomised, non-inferiority trial, women aged 45 years or older with invasive ductal breast carcinoma undergoing breast-conserving surgery were enrolled to compare TARGIT with whole breast external beam radiotherapy (EBRT). The primary outcome was local recurrence in the conserved breast with a predefined absolute non-inferiority margin of 2-5%. Analysis was by intention-to-treat. Results: 1113 patients were randomly allocated to TARGIT and 1119 were allocated to EBRT. The Kaplan-Meier estimate of local recurrence in the conserved breast at 4 years was 1-20% (95% CI 0-53-2-71) in the TARGIT and 0-95% (0.39-2-31) in the EBRT group (difference between groups 0.25%, −1.04 to 1.54; p=0.41). The frequency of any complications and major toxicity (TARGIT 3.3% vs. EBRT 3.9% p=0·44) was similar. Radiotherapy toxicity was lower in the TARGIT group (0.5% vs. 2.1%, p=0.002). 14% of patients who received TARGIT also received EBRT as per the protocol, i.e., the remaining 86% patients could safely avoid 3-6 weeks of daily radiotherapy treatments and its obvious associated costs in economic and human terms. Discussion: For selected patients with early breast cancer, a single-dose targeted intraoperative radiotherapy should be considered as an alternative to whole breast EBRT delivered over several weeks. It could save time, effort, and money for the patient and the healthcare system, which is particularly relevant in the present times of healthcare reform. NB the main trial results have been presented in ASCO 2010 and published in the Lancet Online First. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD06-01.
Immunologic Reactions of Bronchial Tissues in Asthma
Authors: Mary Lou Callerame, John J. Condemi, Milton G. Bohrod, John H. Vaughan
Journal: New England Journal of Medicine (1971)

Bronchial tissues obtained from 18 patients with bronchial asthma showed thickened basement membranes that stained positively for immunoglobulins in five of 11 biopsy specimens and six of seven autopsy specimens. Complement (C3) was identified in the deposit in three cases. IgM was the immunoglobulin most frequently seen. Similar studies in controls demonstrated no basement-membrane thickening, but fluorescence with antiserum to IgG was found in 10 per cent and to IgM in 3 per cent. These deposits beneath the bronchial basement membrane may represent precipitation of antibody from serum with respiratory antigens from the bronchial lumen, a process that appears to occur frequently in asthma and less frequently in other forms of pulmonary disease.
Circulatory and Symptomatic Effects of Physical Training in Patients with Coronary-Artery Disease and Angina Pectoris
Authors: David R. Redwood, Douglas R. Rosing, Stephen E. Epstein
Journal: New England Journal of Medicine (1972)

A six-week program of intensive training in seven patients with angina was carried out to determine the relative contributions to the improved exercise performance of altered circulatory response and enhanced myocardial oxygen delivery. Training resulted in a marked increase in exercise capacity: time to onset of angina (± S.E.M.) rose an average of 6.8 ± 1.5 minutes (p less than 0.01), and the intensity of exercise (measured by total body oxygen consumption) attained before the onset of angina increased 56 ± 19 per cent (p less than 0.005). The "triple product" (an index of myocardial oxygen consumption) at any level of exercise was less after training, thus accounting for part of the improved exercise capacity. In addition after training, a higher triple product could be achieved at the onset of angina, 4885 vs. 4300 (p less than 0.05), suggesting that training might improve myocardial oxygen delivery. Physical training thus seems to improve exercise performance consistently by reducing the responses of heart rate and arterial pressure to exercise. The data also suggest that myocardial oxygen delivery may be enhanced.
PÓLIPOS GÁSTRICOS MAYORES DE 10 MM: CARACTERÍSTICAS ENDOSCÓPICAS, HISTOLÓGICAS Y ACTITUD DIAGNÓSTICO-TERAPÉUTICA
Authors: J García Alonso, RM Martín Mateos, JA González Martín, AI González Tallón, LM Achécar Justo, J Pérez Lasala, M Tejedor Bravo, MA Martín Scapa, A Cano Ruiz, D Boixeda de Miquel
Journal: Endoscopy (2010)

Objetivo: Describir las características endoscópicas e histológicas de los pólipos gástricos mayores de 10mm y la actitud diagnóstico-terapéutica que se llevó a cabo.
Age-Related Modification of 7,12-Dimethylbenz[ a ]anthracene Binding to Rat Mammary Gland DNA 2
Authors: Douglas H. Janss, Theresa L. Ben
Journal: JNCI Journal of the National Cancer Institute (1978)

The binding of 7,12-dimethylbenz[a]anthracene (DMBA) to mammary gland and liver DNA of female Sprague-Dawley rats either 35, 50, or 120 days of age at the time of carcinogen administration was studied. Following a single oral feeding of tritium-labeled DMBA, the level of binding to liver DNA of rats in all 3 age groups was significantly lower, at all times during a 6-week period, than that of binding to mammary DNA. The amount of DMBA bound to liver DNA was a function of the amount of carcinogen administered and not the age of the animal. In contrast, DMBA binding to mammary DNA was dependent on the age of the animal at the time of carcinogen feeding. Furthermore, in the age group with 100% tumor induction (50 days old), DMBA binding increased directly with the amount of carcinogen fed; this was not the case for the other 2 age groups. These results indicated that a significant correlation existed between the age of the rat, the amount of DMBA bound to DNA, and the incidence of mammary tumors following carcinogen feeding.
US elderly find it harder to pay medical bills than counterparts elsewhere, survey finds
Authors: M. McCarthy
Journal: BMJ (2014)

US adults aged 65 years or over are more likely to have chronic health problems and to struggle to pay for medical care than are their counterparts in 10 other developed nations, a new survey indicates.1

However, the Americans surveyed were more likely to report that their doctors had discussed with them how to live a healthy life and to have had conversations with their doctor about advanced care planning and to have a written plan regarding the end of life care they desired.

The survey, published by Health Affairs ,1 was conducted by the Commonwealth Fund, a foundation based in New York City that focuses on health system reform. The lead author was Robin Osborn, the fund’s vice president and director of international health policy and practice innovations. This was the 17th international survey sponsored by the foundation to compare different health systems.

The study was based on a telephone survey of 15 617 adults aged 65 or older in Australia, Canada, France, Germany, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the …
Adult hematopoietic stem cells lacking Hif-1α self-renew normally
Authors: Milica Vukovic, Catarina Sepulveda, Chithra Subramani, Amélie V. Guitart, Jasmine Mohr, Lewis Allen, Theano I. Panagopoulou, Jasmin Paris, Hannah Lawson, Arnaud Villacreces, Alejandro Armesilla-Diaz, Deniz Gezer, Tessa L. Holyoake, Peter J. Ratcliffe, Kamil R. Kranc
Journal: Blood (2016)
Abstract 2344: Soluble MICA in cervical cancer is in a deglycosylated form: Implication for soluble MICA detection
Authors: C Nanok, Sahapat Barusrux, C Leelayuwat
Journal: Cancer Research (2010)

Abstract Background: Major histocompatibility complex class I chain related A (MICA/PERB11.1) molecules are expressed as transmembrane proteins. They are ligands recognized by the natural killer cell receptor group (NKG)2D, an activating receptor on NK cells, gamma delta T cells and activated CD8 T cells. Up-regulated MICA expression was reported in many tumors. Shedding of MICA from tumor cells as soluble MICA (sMICA) is a mechanism for immune evasion. MICA proteins could be presented in various sizes from 43 to 75 kDa depending on degree of glycosylation. Eight potential N-glycosylation sites in a MICA molecule were reported. This study aimed to investigate the size of sMICA in sera of cervical cancer patients and women blood donors by western blot technique. Methods: The sMICA*009 plasmid DNA was transfected to COS7 cells for recombinant sMICA protein production in culture supernatant. The recombinant sMICA protein was harvested and validated with mouse monoclonal anti-MICA antibody (WW6B7) by indirect ELISA and immunobloting. Molecular weight of deglycosylated recombinant sMICA protein treated with N-glycosidase F enzyme and sMICA in cervical cancer and healthy sera was determined. Results: The recombinant sMICA and serum sMICA showed 62 kDa and 45 kDa in molecular weight, respectively. The molecular weight of recombinant sMICA treated with N-glycosidase F enzyme was reduced to 45 kDa which equal to serum sMICA indicating that sMICA in sera of patients and blood donor controls was in a deglycosylated form. Conclusion: Recombinant sMICA produced in COS7 had a molecular weight of 62 kDa. In contrast, sMICA in sera was in a deglycosylated form and had a molecular weight of 45 kDa equal to in vitro deglycosylation with N-glycosidase F enzyme of produced recombinant sMICA. The mechanism and kinetic of deglycosylation of sMICA in sera await further investigation. It would be interesting to see whether this form of sMICA would affect sMICA detection in sera. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2344.
THU0019 BLyS Expression in Synovial Fluids from Rheumatoid Arthritis Patients
Authors: L. Mas, V. Saurit, E. Cortiñas, M. Colazo, A. Alvarellos, T. Alvarellos
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> BLyS is a novel TNF family ligand, mainly secreted by myeloid cellsandsynovial fibroblasts that exerts profound effects on B cells leading to their maturation and increased survival. Local expression of BLyS in inflamed joints from Rheumatoid Arthritis (RA) patients may contribute to the development and progression of disease. <h3>Objectives</h3> We evaluated local gene expression of BLyS in RA patients with disease activity. <h3>Methods</h3> Synovial fluids and Peripherical Blood (PB) were obtained from RA patients and were classified in two groups, Group I: RA evaluated by DAS 28 score as high disease activity (n=10, 7F/3M, age: 56,3 ± 20,9, range: 17-84) and Group II: Osteoarthritis (OA, n=18, 13F/5M, age: 70,5 ± 6,6, range: 58-86). Levels of BLyS expression were evaluated using Quantitative Real Time PCR (QPCR). All amplifications were carried out in duplicate and threshold cycle (C<sub>t</sub>) scores were averaged for calculations of relative expression values. The C<sub>t</sub> scores were normalized against C<sub>t</sub> scores by subtracting the corresponding β2Microglobuline (β2M) control, or ΔCt=C<sub>t,gene</sub>- C<sub>t,B2M</sub>. To test for differential gene expression between groups, a two sample t-test was performed to compare the ΔCt in the two groups. <h3>Results</h3> BLyS gene expression is shown in Table 1. <h3>Conclusions</h3> Increased BLyS expression in active RA SF can be linked to B cell activation and proliferation in RA synovium. <h3>References</h3> Tan SM et al. Local Production of B lymphocyte Stimulator Protein and APRIL in Arthritic Joints of Patients with Inflammatory Arthritis. Arthritis and Rheumatism. 48 (4):982-992 (2003). Kreuzaler M et al. Soluble BAFF Levles inversely correlate with Peripherical B cell numbers and the expression of BAFF receptors. J Immunol. 188: 497-503 (2012). <h3>Disclosure of Interest</h3> None Declared
AB0826-HPR Cognitive functioning of patients with systemic lupus erythematosus with moderate activity of the disease. preliminary report.
Authors: E. H. Mojs, W. Samborski, P. Leszczynski, K. Pawlak-Bus, R. Wojciak, S. Jeka
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which the aetiology includes genetic and environmental factors. The autoimmune mechanisms of the disease are the potential risk factors for the impairment some brain functions also. <h3>Objectives</h3> The goal of the study was to evaluate some cognitive functions belong to the group of executive ones in a group of patients with SLE. Executive functions are related with activity of frontal lobes of brain. The research involved a group of 64 patients with SLE, aged 19-62 yrs, the mean 41,2 yrs, median disease duration 8,3 yrs, the median results in SELENA/SLEDAI 11 points what suggests the moderate activity of the disease. 95% of pts were treated with chlorochine or hydroxychlorochine. <h3>Methods</h3> To verify research hypotheses neuropsychological tests such as 10 – word list, direct memory task for sensible words, digit test, test for evaluation the attention – concentration and the ability of sustaining -D2, attention test CTT, language competencies – Fluency Test, Hand Laterality Test, and estimation of the intelligence – Raven Test. Identification and Interpretation of Emotions in Social Situations and Achenbach's CBCL were used. The research hypotheses were verified by way of Multi – Factor Analysis of Variance (Anova) for quantitative data and Kruskal – Wallis Test for ordinal data while Bonferonni – Dunn Test or Tukey's HSD were used to find relevant differences between groups. Additionally, in case of nonhomogenous variables, non – parametric tests such as Mann – Whitney Two Sample Test and Kruskal – Wallis Test for three or more samples were applied to verify the result of analysis of variance. For nominal data Chi – square test was used while Pearson r was used to measure the correlation between variables. Ethical approval for data management was obtained from the Ethics Committee of the Poznan University of Medical Sciences. <h3>Results</h3> The results show that 14,5% pts with SLE have neurological disorders. Cognitive impairments including direct memory, learning and attention dysfunctions were noticed in 51,6% of all examined pts. In a group with neurological disorders almost all pts revealed low scores in CTT (below 100 sec), the median for Short term memory was 5,6 elements, the median of D2 was below normal scores according to the age of pts. The results of 10 word test was 30, 4 what is low result in comparison to the healthy ones. <h3>Conclusions</h3> The model of SLE treatment should include neuropsychological rehabilitation in order to improve patient's quality of life and to prevent cognitive and social impairments. <h3>Disclosure of Interest</h3> None Declared
LONG-TERM MORTALITY IN PATIENTS WITH SEVERE CHRONIC KIDNEY DISEASE TREATED WITH TRANSCATHETER OR SURGICAL AORTIC VALVE REPLACEMENT: A PROPENSITY-MATCHED ANALYSIS
Authors: Grant W. Reed, Amar Krishnaswamy, Zoran Popovic, Stephanie Mick, Jose Navia, Eric Roselli, Paul Schoenhagen, Lars Svensson, E. Murat Tuzcu, Samir Kapadia
Journal: Journal of the American College of Cardiology (2016)