tbuckley/cabot-search huggingface dataset:
Effect Modification by Time Since Blood Draw on the Association Between Circulating Fatty Acids and Prostate Cancer Risk
Authors: Meng Yang, Howard D. Sesso, Graham A. Colditz, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro
Journal: JNCI Journal of the National Cancer Institute (2016)

A recent meta-analysis suggested that circulating fatty acids do not play an important role in prostate carcinogenesis. We hypothesized that the relation between circulating fatty acids and prostate cancer (PCa) risk is modified by time between blood draw and diagnosis. We tested this hypothesis in a prospective case-control study of 476 PCa cases and matched control subjects nested in the Physicians’ Health Study. The previously reported associations between fatty acids and PCa in this cohort were dramatically stronger among men diagnosed 10 or more years after blood collection. Statistically significant effect modification by time since blood collection was identified for mono-unsaturated and poly-unsaturated fatty acids and was more pronounced for aggressive tumors. Among men diagnosed fewer than 10 years since blood collection, the relative risks per interquartile range were 1.03 (95% confidence interval [CI] = 0.86 to 1.25) for total mono-unsaturated fatty acids (MUFA) and 0.95 (95% CI = 0.78 to 1.15) for total poly-unsaturated fatty acids (PUFA) whereas among men diagnosed 10 or more years after blood draw the relative risks per interquartile range were 1.69 (95% CI = 1.21 to 2.34) for MUFA (Pheterogeneity = .01) and 0.59 (95% CI = 0.42 to 0.83) for PUFA (Pheterogeneity = .02). These data suggest that the results of the meta-analysis may be partly explained by insufficient follow-up time. Furthermore, they suggest that some environmental and metabolic factors may play a role in prostate carcinogenesis decades before clinical identification of this disease.
Soundings: Hank at The Shed
Authors: James Owen Drife
Journal: BMJ (2004)

I liked Hank Wangford even before I met him. His name, perfect for a country and western singer, suggests deadpan mischief. It's made up, of course. In real life, he is a London doctor. He mentions this on stage but doesn't make a big thing of it.

I liked The Shed before I saw it, too. A tiny venue on the edge of the north Yorkshire moors, its gigs include poetry readings on Radio 4 and an improvised bingo and percussion show. On its website (www.theshed.co.uk) are detailed instructions on how to knit your own Elvis wig.

The last time I had met Hank was at the Royal Society of Medicine. We had chatted about contraception and then he told me about falling angels. Kicked out of heaven along with Satan, they were still falling and causing trouble. He thought the idea might make a good song.

Now, on the moors in December, a lad with a lantern directed us to the village hall. Crammed in were 70 seats and little candlelit tables.

In the kitchen Simon, the friendly but pensive impresario, was helping to sell drinks. Hank and his band, the Lonesome Cowboys, were changing in the toilet but would be signing CDs later.

The packed audience included men with pullovers and women with pink Stetsons. Hank told us that he, like everyone else, had once considered country music naffer than naff. Then, one life-changing day 20 years ago, he met one of the genre's greats. Now, according to www.hankwangford.com, he has become its “troubled grubby soul... and walks the thin line between laughter and the dark.”

He mournfully welcomed us to an evening of festive misery and sang songs about death and loneliness. They included a Johnny Cash number about a divorced man learning to fend for himself (“Beans for breakfast once again”) with the exquisite line: “I ain't got no clean utensils.” And a wonderful song about falling angels.

As we left, Simon was there in the darkness, handing out fliers for a forthcoming concert by an avant-garde string quartet from the Netherlands. Britain was experiencing a meteorite shower and on the long drive back to Leeds the sky was full of shooting stars. Angels? On this surreal night, I could believe it.
Reduced Intensity Allogeneic Stem Cell Transplant In Patients With Multiple Myeloma: A Comparison Of Planned Autologous-Reduced Intensity Allogeneic Stem Cell Transplant (Auto-Allo) and Reduced Intensity Allogeneic Stem Cell Transplant (RIC) As Upfront Transplant In Patients With Multiple Myeloma, An EBMT Analysis
Authors: Firoozeh Sahebi, Simona Iacobelli, Anja Van Biezen, Liisa Volin, Peter Dreger, Mauricette Michallet, Per T. Ljungman, Goesta Gahrton, Curly TCM Morris, Stefan Schonland, Theo de Witte, Laurent Garderet, Nicolaus Kroeger, Anja Henseler, Nicolaas PM Schaap, D Caballero, Xavier Poire, Jakob Passweg, Rose-Marie Hamljadi
Journal: Blood (2013)
TB-19AUTOPHAGY INHIBITION OVERCOMES RESISTANCE TO BRAF INHIBITION IN BRAIN TUMORS
Authors: Jean Mulcahy Levy, Shadi Zahedi, Andrea Griesinger, Kurtis Davies, Dara Eisner, B.K. Kleinschmidt-DeMasters, Brent Fitzwalter, Megan Goodall, Vladimir Amani, Andrew Donson, Diane Birks, David Mirsky, Todd Hankinson, Michael Handler, Nicholas Foreman, Andrew Foreman
Journal: Neuro-Oncology (2016)

TB-19. AUTOPHAGY INHIBITION OVERCOMES RESISTANCE TO BRAF INHIBITION IN BRAIN TUMORS Jean Mulcahy Levy, Shadi Zahedi, Andrea Griesinger, Kurtis Davies, Dara Eisner, B.K. Kleinschmidt-DeMasters, Brent Fitzwalter, Megan Goodall, Vladimir Amani, Andrew Donson, Diane Birks, David Mirsky, Todd Hankinson, Michael Handler, Nicholas Foreman, and Andrew Foreman; Department of Pediatrics, University of Colorado Denver, Aurora, CO, USA Kinase inhibitors are effective in cancer treatment but beneficial effects are almost invariably short-lived as tumors become resistant to the inhibitor. Current strategies to circumvent resistance target the same pathway another way or inhibiting a parallel pathway. Here, we report that it is possible to overcome resistance to the BRAF inhibitor vemurafenib in BRAF mutant brain tumors by targeting a completely different cellular process. BRAF mutation occurs in a high proportion of children’s brain tumors and we previously reported that these brain tumor cells are autophagydependent. We also reported a patient who was successfully treated after failure of vemurafenib by adding the autophagy inhibitor chloroquine (CQ) to vemurafenib suggesting that autophagy inhibition overcame kinase inhibitor resistance. In the present study, we tested this hypothesis by modeling acquisition of vemurafenib resistance in brain tumor cell lines. Both genetic and pharmacological inhibition of autophagy could overcome resistance due to multiple mutations and compensatory mechanisms. To evaluate clinically-acquired drug resistance, we tested tumor slices and primary tumor cells from patients with resistance to vemurafenib. Pharmacological inhibition of autophagy reversed resistance, inhibited tumor cell growth, and increased tumor cell death in vitro; moreover, when it was possible to test, the same patient had favorable clinical responses when CQ was added to vemurafenib. Our results provide proof of concept for a fundamentally different way to circumvent kinase inhibitor resistance in cancer therapy, and suggest a strategy for improved treatment of a large proportion of children’s brain tumors that could be rapidly tested in clinical trials. Neuro-Oncology 18:iii169–iii173, 2016. doi:10.1093/neuonc/now084.13 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Epidemiology of Adults AML in Nord-Pas De Calais and Picardy
Authors: Christophe Roumier, Céline Rodriguez, Cécile Frimat, Céline Berthon, Carole Delattre, Marc Wetterwald, Jose Fernandes, Agnes Daudignon, Isabelle Plantier, Agnes Charpentier, Stéphane Darre, Bachra Choufi, Laure Stalnikiewicz, Christine Ghevaert, Jean-Pierre Marolleau, Veronique Harrivel, Olivier Nibourel, Catherine Roche, Bruno Quesnel, Claude Preudhomme
Journal: Blood (2014)
Remission Maintenance Therapy for Meningeal Leukemia: Intrathecal Methotrexate vs. Intravenous bis-Nitrosourea
Authors: MARGARET P. SULLIVAN, TERESA J. VIETTI, MARY ELLEN HAGGARD, MILTON H. DONALDSON, JOHN M. KRALL, EDMUND A. GEHAN
Journal: Blood (1971)
Genetic diversity of highly pathogenic H5N8 avian influenza viruses at a single overwintering site of migratory birds in Japan, 2014/15
Authors: M Ozawa, A Matsuu, K Tokorozaki, M Horie, T Masatani, H Nakagawa, K Okuya, T Kawabata, S Toda
Journal: Eurosurveillance (2015)

We isolated eight highly pathogenic H5N8 avian influenza viruses (H5N8 HPAIVs) in the 2014/15 winter season at an overwintering site of migratory birds in Japan. Genetic analyses revealed that these isolates were divided into three groups, indicating the co-circulation of three genetic groups of H5N8 HPAIV among these migratory birds. These results also imply the possibility of global redistribution of the H5N8 HPAIVs via the migration of these birds next winter.
Diagnostic accuracy of unenhanced and gadolinium-enhanced magnetic resonance imaging for acute pulmonary embolism diagnosis: Results of the “IRM-EP” study
Authors: Olivier Sanchez, Marie-Pierre Revel, Sophie Couchon, Benjamin Planquette, Anne Hernigou, Ralph Niarra, Catherine Lefort, Gilles Chatellier, Guy Meyer
Journal: European Respiratory Journal (2011)

Context: Magnetic resonance imaging (MRI) has not been yet fully evaluated for diagnosing pulmonary embolism (PE).

Aim: To evaluate MRI performance for PE diagnosis by reference to 64-detector CT angiography (CTA) in patients with clinical suspicion of PE.

Intervention: MRI including, unenhanced ECG-gated, perfusion and angiographic sequences was performed within 24 hours from CTA and were interpreted by two independent readers blinded to CTA results.

Measures: Sensitivity, specificity evaluated globally and for each sequence. Inter reader agreement evaluated with the kappa statistics.

Results: Among 300 patients included, 274, with a conclusive CTA, completed the whole MRI protocol, of which 103 had PE on CTA (prevalence: 37.5%). 76 of the 274 MRI examinations (28%) were judged inconclusive by reader 1 and 83 (30%) by reader 2. Sensitivity and specificity of conclusive MRI on global readings were 84.5% (95% CI, 74.9% to 91.4%) and 99.1% (95% CI, 95.1% to 100.0%) for reader 1 and 78.7% (95% CI, 68.2% to 87.1%) and 100% (95% CI, 96.7% to 100.0%) for reader 2, respectively. Sensitivity was better for proximal (97.7 to 100%) than for segmental (68 to 91%) and sub segmental PE (21 to 33%). Angiographic sequences showed the highest performance and agreement (Kappa: 0.77). Unenhanced sequences, although less sensitive, showed high specificity (96.1%) and good agreement (Kappa: 0.62), whereas perfusion sequences showed lower sensitivity, specificity and agreement.

Conclusion: MRI demonstrates high specificity, even for unenhanced sequence and acceptable sensitivity for PE diagnosis at the cost of a 28% to 30% rate of inconclusive result.
Crossed Fused Renal Ectopia
Authors: Eun Ha Moon, Min-Woo Kim, Young Jun Kim, In O Sun
Journal: Clinical Nuclear Medicine (2015)

Crossed renal ectopia is an uncommon developmental anomaly in which both kidneys are located on the same side of the body. The present case describes a 20-year-old man who underwent the military entrance physical examination. The ultrasound showed the right kidney in normal site with slightly increased size, but the left kidney was not identified. Tc-MAG3 scan showed a single kidney with 2 ureters, and the orifices of the ureters were connected at both sides of bladder. Tc-DMSA SPECT and contrast-enhanced multidetector CT were performed and revealed crossed fused renal ectopia.
Nortriptyline treatment of depressed cardiac transplant recipients
Authors: P A Shapiro
Journal: American Journal of Psychiatry (1991)

The safety of tricyclic antidepressants in cardiac transplant recipients has not been established. The author used nortriptyline to treat major depressive episodes in eight cardiac transplant recipients. Nortriptyline therapy was associated with increased QRS interval and heart rate but did not significantly affect other hemodynamic or ECG variables or cyclosporine dose requirements. It appears that nortriptyline may be used safely in depressed cardiac transplant patients.
Inflammatory arthritis and sicca syndrome induced by nivolumab and ipilimumab
Authors: Laura C Cappelli, Anna Kristina Gutierrez, Alan N Baer, Jemima Albayda, Rebecca L Manno, Uzma Haque, Evan J Lipson, Karen B Bleich, Ami A Shah, Jarushka Naidoo, Julie R Brahmer, Dung Le, Clifton O Bingham
Journal: Annals of the Rheumatic Diseases (2016)

Immune checkpoint inhibitors (ICIs) targeting the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) pathways have demonstrated survival improvements in multiple advanced cancers, but also cause immune-related adverse events (IRAEs). IRAEs with clinical features similar to rheumatic diseases have not been well described. We report patients with inflammatory arthritis and sicca syndrome secondary to ICIs.We report patients evaluated in the Johns Hopkins Rheumatology clinics from 2012 to 2016 identified as having new rheumatological symptoms in the context of treatment with ipilimumab (anti-CTLA-4) and/or nivolumab (anti-PD-1) for solid tumours.We identified 13 patients who received ICIs and developed rheumatological IRAEs. Mean age was 58.7 years. Cancer types included melanoma, non-small cell lung cancer, small cell lung cancer and renal cell carcinoma. ICI regimens included nivolumab or ipilimumab as monotherapy (n=5), or combination nivolumab and ipilimumab (n=8). Nine of 13 patients developed an inflammatory arthritis, 4 with synovitis confirmed on imaging (3 ultrasound, 1 MRI) and 4 with inflammatory synovial fluid. Four patients developed sicca syndrome with severe salivary hypofunction. Other IRAEs included: pneumonitis, colitis, interstitial nephritis and thyroiditis. Antinuclear antibodies were positive in 5 out of 13 patients. All 13 patients were treated with corticosteroids with varying response. Two patients were treated with methotrexate and antitumor necrosis factor therapy for inflammatory arthritis.As ICIs are increasingly used for a range of malignancies, new cases of rheumatic IRAEs are likely to emerge. Further research is required to understand mechanisms, determine risk factors and develop management algorithms for rheumatic IRAEs.
Price Hikes of Old Prescription Drugs Affect Physicians, Hospitals, Patients
Authors: Rita Rubin
Journal: JAMA (2016)

Sudden price hikes of decades-old prescription drugs represent a market failure with far-reaching consequences, Sen Susan Collins (R, Maine), chair of the Senate Special Committee on Aging, said at a series of hearings on the subject (http://1.usa.gov/1rezDbf).
Fox rabies in Germany – an update
Authors: T Müller, T Selhorst, C Pötzsch
Journal: Eurosurveillance (2005)

In comparison with conventional methods of wildlife rabies control, oral rabies vaccination of foxes (ORV) is without doubt the most (cost-) effective method in wildlife rabies control. As a result of ORV, several European countries have become rabies-free. Although rabies had been eliminated from much of Germany, there still exists a residual rabies focus in the border triangle of Hesse, Baden-Wurttemberg and Rhineland Palatinate. Corrective actions have been initiated to eliminate this last remaining rabies hotspot in Germany.
Poor outcome and low platelet MAO activity in chronic schizophrenia
Authors: L Bierer, J P Docherty, J G Young, E Giller, D Cohen
Journal: American Journal of Psychiatry (1984)

Platelet monoamine oxidase (MAO) activity was significantly lower among 21 chronic schizophrenic patients, 19 of whom were receiving stable doses of antipsychotic medication, than among 16 control subjects. Poor ego functioning and poor outcome were significantly correlated with low MAO activity; current dose of major tranquilizer was negatively but not significantly correlated. The degree of psychopathology, rather than presence or absence of specific symptom constellations, was the significant characteristic of patients with low enzyme levels. This finding is in accordance with those of earlier studies of schizophrenic patients as well as with recent findings in nonschizophrenic samples.
BENIGN RECURRENT HEMATURIA IN CHILDREN
Authors: W D BOWMAN
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RO-05IMPROVING INFORMATION FOR PAEDIATRIC CANCER PATIENTS
Authors: Shona Mackie, Krishnachandran Chandrasekharan, Inga Driver, Omar Al-Salihi, Jenna Everett
Journal: Neuro-Oncology (2016)

RO-05. IMPROVING INFORMATION FOR PAEDIATRIC CANCER PATIENTS Shona Mackie1, Krishnachandran Chandrasekharan2, Inga Driver2, Omar Al-Salihi2, and Jenna Everett2; Paediatric Oncology, Southampton Children’s Hospital, Southampton, UK; Clinical Oncology, Southampton University Hospital, Southampton, UK Southampton Children’s Hospital Oncology service treats children from across the south of England and sees approximately 100 new diagnoses per year. Of these, an average of 35 patients per year receive radiotherapy as part of their treatment. Preparation is essential for patient compliance and the key to successful treatment. In 2014 the paediatric oncology Multidisciplinary team identified that younger children had excellent materials, however the resources for older children were outdated and unfit for purpose. OBJECTIVE: To produce a modular information DVD for children over eight years old. METHOD: Six children on or recently completed radiotherapy consented to participate. Loaded Productions, a company specialising in medical films, produced the DVD. RESULTS: Filming took place during weekends to minimise disruption to the clinical service and included local departmental staff. Treatments including head and neck mask, vac bag and limb board were filmed to show a variety of immobilisation forms. Informal unstructured interviews enabled the participants to describe their experiences in their own words and their personalities and experiences became an important part of the final product. The DVD was designed in a module format for easeofviewingandtoavoid informationoverload.Newpatientshavereported that the DVD relieved some of their fears and uncertainties, parents have also found it gives them the information they needed to support their child. CONCLUSION: The formulation of a DVD linked to local practices and personnel that children will encounter can support radiotherapy preparation, reduce parental and patient anxiety and improve compliance. Neuro-Oncology 18:iii159–iii164, 2016. doi:10.1093/neuonc/now082.5 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
The Central Region of TEL (ETV6) Is Dispensable for the TEL/AML1 (ETV6/RUNX1) Leukemogenesis.
Authors: Marketa Zaliova, Claus Meyer, Gunnar Cario, Martina Vaskova, Rolf Marschalek, Jan Stary, Jan Zuna, Jan Trka
Journal: Blood (2009)
The hidden Chagas disease burden in Europe
Authors: P Albajar-Viñas, J Jannin
Journal: Eurosurveillance (2011)

Preview this article: The hidden Chagas disease burden in Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/38/art19975-en-1.gif
Case 4-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Kurt J. Isselbacher, Benjamin Castleman
Journal: New England Journal of Medicine (1970)

Presentation of CaseA sixty-five-year-old woman was admitted to the hospital because of weakness and fatigue of two years' duration.She had been well until two years previously, when there was the onset of increasing fatigue, exertional dyspnea, cold intolerance and constipation. Coarsening of the hair and thickening of the skin of the hands and feet occurred. On exposure to cold she experienced painful blanching of the hands, followed by erythema, numbness and tingling. Ten months before admission she began to have frequent eructation and regurgitation of food, without nausea or abdominal pain. Undigested food particles were produced during nocturnal . . .
Case 17-1966
Authors: George L. Nardi, Benjamin Castleman
Journal: New England Journal of Medicine (1966)

Presentation of CaseA seventy-five-year-old man was admitted to the hospital because of pain in the abdomen.Six years previously he was admitted to another hospital because of a "stroke," and he was described as nervous and difficult to manage thereafter. Six months before admission he began to complain of heartburn, and postprandial vomiting occurred frequently after that time. Four months later abdominal pain developed, with radiation to the back. During the two months before admission his appetite progressively diminished, and for the two weeks before entry he ate almost nothing. The urine was believed to have been red on . . .
Laboratory support for the diagnosis and surveillance of sexually transmitted infections (STIs) in Eastern Europe
Authors: M Domeika, M Unemo, R C Ballard, Collective on behalf of the Eastern European N
Journal: Eurosurveillance (2009)

This report outlines the proceedings of the 4th Annual Meeting of the Eastern European Network for Sexual and Reproductive Health (EE SRH Network) [1,2], which took place at Uppsala University in Uppsala, Sweden between 30 May and 3 June, 2009.
Spatial normalization of brain images and beyond
Authors: J.-F. Mangin, J. Lebenberg, S. Lefranc, N. Labra, G. Auzias, M. Labit, M. Guevara, H. Mohlberg, P. Roca, P. Guevara, J. Dubois, F. Leroy, G. Dehaene-Lambertz, A. Cachia, T. Dickscheid, O. Coulon, C. Poupon, D. Rivière, K. Amunts, Z.Y. Sun
Journal: Medical Image Analysis (2016)
SPINAL-CORD INJURY AT BIRTH
Authors: J J POLLARD, R A NEBESAR
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal