tbuckley/cabot-search huggingface dataset:
P56 Malignant pleural mesothelioma in North East Scotland
Authors: ADL Marshall, IM Murray, S Wedderburn, K Kerr, GP Currie
Journal: Thorax (2013)

<h3>Introduction</h3> We wished to highlight demographics and evaluate prognostic factors and outcomes in all patients regionally with confirmed malignant pleural mesothelioma (MPM). <h3>Methods</h3> Data relating to all consecutive patients between 2002 and 2012 (inclusive) with biopsy proven MPM were identified from a local pathology database. Demographics, diagnostic method, histological sub-type, survival and laboratory parameters at diagnosis were extracted from computer archives. Comparisons were made between patients surviving greater than 1 year and less than one year. <h3>Results</h3> 138 patients had confirmed MPM between 2002 and 2012 (118 (86%) male, 57% right sided, and median age 70 years (range 48 88)). Of these, 55% were classed as epithelioid, 16% biphasic, 16% sarcomatoid and 13% had no definitive typing. Overall median survival from diagnosis was 292 days (IQR 72, 497); 406, 297, 61 and 314 days for epithelioid, biphasic, sarcomatoid and “not defined” respectively. Factors associated with a higher risk of dying in less than one year after diagnosis were advanced age (median 73 vs 66 years, p = 0.0002), low haemoglobin (12.8 vs 14.0 g/L, p = 0.001), high platelets (366 vs 317 x10^<sup>9</sup>/L, p = 0.0269), low sodium (138 vs 139 mmol/L, p = 0.02), low albumin (38 vs 41 g/L, p = 0.0003), high alkaline phosphatase (101 vs 85 U/L, p = 0.013) and high C reactive protein (64 vs 26 mg/L, p = 0.0051). Between 2006 2012, 37 of 76 patients received chemotherapy; those who did had a greater median survival (median survival 423 days (IQR 326 624) vs 95 days (IQR 60 321), p = &lt; 0.0001). <h3>Conclusion</h3> Overall median survival in consecutive patients with MPM was 292 days, with adverse prognostic factors being low haemoglobin, sodium and albumin, high platelets, alkaline phosphatase and CRP and advanced age. Patients receiving chemotherapy had a better prognosis overall.
AB1447-HPR The efficacy of low level laser therapy in the treatment of calcaneal spur
Authors: E. Cinar, F. Uygur, S. Toprak Celenay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Plantar heel spur syndrome or calcaneal spur is radiologically described as an exostotic plantar bone formation at the insertion of the plantar fascia and muscles. Painful plantar heel is a relatively common clinical entity and plantar fasciitis and calcaneal spurs are frequently associated with this condition. Despite the common use of low level laser to accelerate wound healing, lessen pain, decrease inflammation and speed recovery, the efficacy of its use in musculoskeletal problems such as calcaneal spur still remains contentious. <h3>Objectives</h3> The aim of this study was to investigate the efficacy of low-level laser therapy (LLLT) in the treatment of calcaneal spur. <h3>Methods</h3> Fifteen patients with calcaneal spur were included in the study. Demographic data of patients was recorded. Infrared Gallium-Aluminum-Arsenide (Ga-Al-As) laser therapy with 850nm wavelength was applied for 9 sessions 3 times a week. For perceived quality of life assessment Maryland Foot Score and Foot Function Index (FFI) were used. 100 meter walk test was used to evaluate walking speed, and cadence was calculated. <h3>Results</h3> Eight female and seven male subjects had a mean age of 48.66±11.15 years and a mean body index of 32.74±7.82 kg/m<sup>2</sup>.Pre-post treatment values showed a significant difference in favour of post treatment values in the pain and terrain items of Maryland Foot Score (p&lt;0.05). There were no significant differences between the other parameters of Maryland Foot Score (distanced walked, stability, limp, shoes, stair, support) (p&gt;0.05). After LLLT significant differences were also found for cadence and walking speed and for all the parameters of the Foot Function Index in favour of post treatment values. <h3>Conclusions</h3> LLLT is effective in treating calcaneal spur.For more conclusive results, controlled trials with larger groups are needed. <h3>References</h3> Basford RJ, Malanga AG, Krause AD, Harmsen SW (1998) A randomized controlled evaluation of low intensity laser therapy: Plantar fasciitis. Arch Phys Med Rehab 79:249–254. Djavid GE, Mortazavi SMJ, Basirnia A et al (2003) Low level laser therapy in musculoskeletal pain syndromes: pain relief and disability reduction. Lasers Surg Med Suppl 15:43–43. Meadows M, Taking Care of Your Feet. FDA Consumer; Mar/Apr 2006; 40, 2. <h3>Disclosure of Interest</h3> None Declared
AB1331 The impact of systemic lupus erythematosus on employment loss from a population-based cohort:
Authors: S.S. Lim, G. Dennis, H. Kan, P. Jhingran, C.T. Molta, G. Bao, C. Drenkard
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic lupus erythematosus (SLE) predominantly develops in younger age groups, when many are establishing themselves in the workforce. The development of a chronic, autoimmune condition during this period can have a devastating impact on employment. <h3>Objectives</h3> To determine the impact of SLE on employment loss from a large, population-based cohort. <h3>Methods</h3> The source of data was from the 2011 annual patient-reported survey of the Georgians Organized Against Lupus (GOAL), an ongoing population-based cohort of patients with validated SLE in Atlanta, Georgia assembled from the Georgia Lupus Registry (GLR). The GLR is supported by the Centers for Disease Control and Prevention and designed to more accurately estimate the incidence and prevalence of SLE. In partnership with the state health department, the GLR was able to access protected health information without patient consent from hospitals (20), rheumatologists (35), nephrologists (10), dermatologists (20), commercial labs, and population databases. The GOAL cohort aims to assess the physical, psychological and socio-economic burden of SLE utilizing validated instruments. GOAL participants were surveyed between August and November of 2011 for this analysis. Employment status at time of SLE diagnosis and survey completion was assessed to define employment loss. Among those employed at SLE diagnosis, logistic regression analysis was used to study the association between socio-demographic factors and employment loss by the time of the 2011 survey. Employment loss was defined as receiving disability benefits (private or Social Security) or being unemployed if younger than 65. <h3>Results</h3> 512 SLE patients were surveyed with a mean age of 47.3 (SD 13.4), 14.4 (SD 9.1) years of disease, and 14.2 (SD 2.9) years of education. 93.2% were female, 75.9% were black and 15.9% white. 3 Asians and 16 with unknown race were not included in the multivariate analysis. At the time of SLE diagnosis, 390 (76.2%) were working and 31(6.1%) were unemployed or retired. Among the 390 who were working at diagnosis, 109 (27.9%) were still working at survey completion (median time since diagnosis=12.7 years, IQR 8.5-19.4), while 47 (12.1%) were unemployed and 176 (45.1%) were receiving disability benefits. The median times from SLE diagnosis to employment loss and from employment loss to survey completion were 3.2 years (IQR 0.1-9.8) and 7.1 years (IQR 3.1-13.1), respectively. The remaining 58 were retired, a homemaker, student, unemployed ≥65 of age, or unable to classify. <h3>Conclusions</h3> SLE has profound impact on employment. Black race, older age at diagnosis and lower education were associated with job loss. Additional study of factors that impact employment is warranted. <h3>Disclosure of Interest</h3> None Declared
COMPARISON OF DIFFERENT QT INTERVAL MEASUREMENTS IN THE ASSESSMENT OF QTC DURING DOFETILIDE ADMINISTRATION IN PATIENTS WITH ATRIAL FIBRILLATION
Authors: N. Gurukripa Kowlgi, Arushi Khurana, Maria Theresa Santos, Salman Khalid, Constancia Macatangay, Jeffrey Kluger
Journal: Journal of the American College of Cardiology (2015)
Abstract 1539: Impact of glioma cell gene expression due to semaphorin expression
Authors: Julia Bode, Silke Kietz, Max Lakomek
Journal: Cancer Research (2011)

Abstract Malignant brain tumours, like the Glioblastoma multiforme, belong to the most frequent tumours encountered in childhood. Unfortunately, even with optimal therapy, consisting of surgical resection and radiotherapy, a glioblastoma multiforme is essentially incurable. In contrast to the excellent results of well established treatment studies in pediatric patients suffering from leukaemia the cure rates of children with malignant brain tumors remained low. That is why the development of new antitumor strategies has become a major issue in experimental neurology. Class-3 semaphorins were first identified as glycoproteins that negatively mediate neuronal guidance by binding to neuropilin. The discovery of more widespread expression of class-3 semaphorins in different tumour cell types implicates a role in tumour biology. The overexpression of class-3 semaphorins in breast cancer cells leads to inhibition of tumour growth. We overexpressed class-3 semaphorins in the human glioma cell line U87MG and monitored a reduction of tumour growth after intracerebral implantation into mice, too. We were also able to detect changes in adhesion and migration. To determine the variation of tumour cell behaviour we analysed the gene expression profile of class-3 overexpressing cells via microarray analysis. We validated changes in transcription levels with the help of realtime-PCR. Changes in the gene expression levels of cell adhesion molecule 2 and Integrin alpha 7 confirmed the changes in adhesion and migration of class-3 semaphorin expressing glioma cells. Further investigations of changes in gene expression levels of different genes are needed to determine the effect of semaphorins on adhesion and migration and the determine the use of class-3 semaphorins as anti-tumour agent. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1539. doi:10.1158/1538-7445.AM2011-1539
Remembering the ABC's
Authors: Thomas P. Duffy
Journal: New England Journal of Medicine (1994)

During a hospitalization for recurrent pneumonitis, a 40-year-old mildly retarded woman with Down's syndrome, Crohn's disease, a seizure disorder, and chronic renal disease requiring maintenance hemodialysis began to have bilateral eye pain.There is nothing that I as a nephrologist can specifically associate with renal failure as a cause of bilateral eye pain. Mineral conjunctivitis, the characteristic red eyes of renal failure, occurs when inadequate dialysis results in an elevated calcium:phosphate ratio; this complication should have been averted in any modern dialysis center. Crohn's disease does have iritis and uveitis as extraintestinal manifestations; an ophthalmology consultation would assist . . .
Recurrent Ureteric Transitional Cell Carcinoma Presenting as an Isolated Brain Metastasis
Authors: Punit Sharma, Piyali Chatterjee
Journal: Clinical Nuclear Medicine (2014)

Brain metastasis from transitional cell carcinoma (TCC) of the ureter is extremely rare. Here we present a case of a 73-year-old woman, a follow-up case of ureteric TCC in whom isolated brain metastasis was incidentally detected at follow-up 18F-FDG PET/CT. This was corroborated with MRI. She underwent excision of the lesion, and histopathology confirmed metastatic TCC.
Abstract 5292: Role of voltage-gated Na+ channels in the metastatic potential of colon cancer cells
Authors: Carrie House, Charles Vaske, Arnold Schwartz, Vincent Obias, Narine Sarvazyan, Tim Hales, Joshua Stuart, Norman Lee
Journal: Cancer Research (2010)

Abstract Ion channels are major signaling proteins spanning the plasma membrane where they enable the diffusion of specific ions into and out of a variety of cells. Voltage-gated Na+ channels (VGSCs) are responsible for the depolarization phase of neuronal action potentials and their activity is required for neurite extension and neurotransmitter release. Aberrant expression of VGSCs has recently been implicated in cancer. Overexpression of VGSCs appears to be associated with increased motility and invasive potential in vitro, whereas treatment with pharmacological agents that block Na+ currents, significantly reduce invasion. We have recently identified functional VGSCs in SW480, SW620, and HT29 colon cancer cells and examined their role in invasion. Electrophysiological techniques were employed to confirm functional expression of the SCN5A isoform in colon cancer cells. The more invasive SW620 cell line has a higher current density and increased protein expression compared to the less invasive SW480 and HT29 cell lines. Furthermore, we used RNA interference and VGSC blockers (tetrodotoxin and lidocaine) to inhibit channel expression and activity, respectively, and demonstrated a loss of invasive potential. Conversely, treatment with veratridine, a neurotoxin that prevents complete inactivation of VGSCs, increased Na+ influx and led to higher invasive potential. In addition to colon cancer cell lines, the expression of Nav1.5, the protein encoded by SCN5A, was examined in colon cancer patient samples by immunohistochemistry. Expression of this channel was restricted to the lumen of colon cancer specimens when compared to their normal matched controls. The contribution of this channel to metastatic behavior has not been previously demonstrated in colon cancer. To facilitate a further understanding of the mechanism by which this channel induces invasive potential, we have analyzed the involvement of SCN5A in activation of the MAPK pathway, which is deregulated in many cancers. Coincidentally, this pathway is also activated after depolarization in neurons during neurogenesis. Lastly, we show that SCN5A participates in the regulation of a colon cancer transcriptional network important for invasion. Taken together, our data suggest that VGSCs contribute to the metastatic potential of colon cancer cells through activation of the MAPK pathway and transcriptional regulation of genes important for the invasion process. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5292.
Conceptual implications of kinship terminological systems: Special problems and multiple analytic approaches
Authors: David B. Kronenfeld
Journal: Behavioral and Brain Sciences (2010)

Abstract I raise issues concerning Jones' Seneca analysis, its relationship to analyses of Dravidian-, Crow-, and Omaha-type systems. These affect the convincingness of his kinship study, and thus the wider conclusions that he wants to draw regarding human cognition and language.
Abstract 1709: Activation of androgen signaling axis by NF-kappaB2/p52
Authors: Nagalakshmi Nadiminty, Wei Lou, Allen C. Gao
Journal: Cancer Research (2010)

Abstract INTRODUCTION: Castration-resistant progression of prostate cancer occurs in &amp;gt;80% of patients after failure of hormonal therapy but the underlying mechanisms are incompletely understood. Emerging evidence implies that ligand-independent activation of the androgen receptor (AR) is of critical importance during this process. Our previous studies show that the levels of NF-κB2/p52 are elevated in prostate cancer cells and that active NF-κB2/p52 promotes prostate cancer cell growth in vitro and in vivo. In this study, we examined the role of NF-κB2/p52 in the aberrant activation of the AR during castration resistant progression, in contrast to the interaction between the AR and RelA/p65. METHODS: The effects of NF-κB2/p52 on cell survival, growth and androgen responsiveness were examined in prostate cancer cells. Modulation of LNCaP tumor growth by p52 was examined in intact and castrated male nude mice. Effect of p52 or p65 on AR activation was examined using luciferase assays, EMSA, ChIP assays and ELISA. RESULTS: Expression of NF-κB2/p52 enhanced androgen-sensitive LNCaP human CaP cell growth and clonogenic ability in androgen-deprived conditions in vitro. LNCaP cells expressing p52 exhibited protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Adenoviral mediated p52 expression in LNCaP cells induced tumor growth in castrated male nude mice. NF-κB/p52 induced the activation of the AR resulting in increased transactivation of AR-responsive genes such as PSA and NKX3.1 in a ligand-independent manner. NF-κB2/p52 enhanced nuclear translocation and transactivation of AR by interacting with its N-terminal domain and enhanced the recruitment of co-activators like p300 to the promoters of AR-dependent genes. These results were confirmed in 3 different prostate cancer cell lines: LAPC-4 (wild type AR), LNCaP (mutant AR) and C4-2 (androgen-insensitive). Transfection of p52 into LAPC-4 and LNCaP cells (which express low levels of p52) showed increased activation of the endogenous AR. Downregulation of endogenous p52 in C4-2 cells resulted in abrogation of AR constitutive activation. In contrast, we observed that p65 exhibited transcriptional repression of the AR, and did not induce expression of AR-responsive genes, PSA and NKX3.1. CONCLUSIONS: These findings demonstrate that overexpression of NF-κB2/p52 induces castration-resistant growth and aberrant activation of the AR in LNCaP cells. NF-κB2/p52 may promote castration resistant progression by activating the AR under conditions of androgen deprivation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1709.
PTH-119 Nurses and Endoscopists are Equally good at Gauging Patient Distress During Endoscopy: Abstract PTH-119 Table 1
Authors: A J Irvine, M Kurien, R Harrold, L Taylor, D S Sanders
Journal: Gut (2013)

<h3>Introduction</h3> Endoscopic procedures have the potential to be uncomfortable and distressing. Previous studies have suggested nurses are better than endoscopists at gauging patient’s pain during endoscopy, possibly reflecting the endoscopists focus on the procedure as opposed to the nurse whose focus remains on the patient. Currently, there is a paucity of work evaluating distress another important marker of endoscopic tolerability. This study evaluates endoscopists’ and nurses’ ability to gauge patient’s distress during gastrointestinal endoscopic procedures. <h3>Methods</h3> Consecutive patients attending for clinically indicated gastrointestinal endoscopy were prospectively recruited from a tertiary referral centre between September 2011 and June 2012. Following informed consent being obtained patients were asked to record distress post endoscopy using a validated numeric rating scale (NRS), with scores recorded between 0 (no distress) and 10 (worst distress imaginable). Endoscopists undertaking the procedure and their assisting nurses were then asked to give their estimates of patient’s distress using the same NRS, with recordings undertaken separately so as not to influence potential outcomes. Data was analysed using SPSS version 20, with a correlation coefficient used to determine levels of agreement in distress scores. <h3>Results</h3> 929 patients were recruited to the study (425 (46%) male, median age of 58 years, range 17–92 years). Of these, 306 (33%) underwent an OGD, 304 (33%) had a colonoscopy, 100(11%) had a flexible sigmoidoscopy, 86 (9%) had an endoscopic ultrasound, 100 (11%) had an ERCP and 33 (4%) had a double balloon enteroscopy. 319 (34%) of the patients recruited had NRS scores &gt; 5 for distress, with multivariate analysis identifying pre-procedure anxiety (p &lt; 0.0001) as the only variable predictive of patient distress. Both endoscopist and nurse assessments of patient’s distress moderately correlated with the patient’s actual reported distress (Table 1), with significant correlation identified between each other. <h3>Conclusion</h3> This study demonstrates that estimates of patient’s distress during endoscopy are comparable between nurses and endoscopists. Whilst this finding is reassuring, procedural pain remains an important outcome measure better identified by nursing staff. We advocate that increased importance should be given to nursing assessments during endoscopic examinations. <h3>Disclosure of Interest</h3> None Declared.
Intracranial Malignant Fibrous Histiocytoma With Increased Uptake on Tl-201 Imaging
Authors: YOSHINORI HAYASHI, NADUNA KIMURA, YOSHINORI BANDOH, NAOMI FUJIMOTO, YUKIO KOHYAMA, HISAJIRO KUMAGAI
Journal: Clinical Nuclear Medicine (1996)

An 80-year-old woman had a malignant fibrous histiocytoma in the right frontal lobe. Clinically, no extracranial source for this tumor was found. Intracranial malignant fibrous histiocytoma is a rare occurrence. The preoperative Tl-201 scintigram showed increased uptake on early and delayed imaging.
IMPACT OF ATRIAL FIBRILLATION ON OUTCOMES AND COST IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Saurabh Aggarwal, Rohit Loomba, Navdeep Gupta, Arun Kanmanthareddy, Manu Kaushik, Venkata Alla, Claire Hunter, Aryan Mooss, Rohit Arora, Dennis Esterbrooks
Journal: Journal of the American College of Cardiology (2016)
Biliary papillomatosis diagnosed with mother-daughter narrow-band imaging (NBI) cholangioscopy
Authors: F. Donnellan, M. Swan, G. May, P. Kortan
Journal: Endoscopy (2011)

A previously healthy 47-year-old man presented to our institution with a 6-month history of recurrent episodes of jaundice and pruritus. Over this period a number of endoscopic retrograde cholangiographies (ERCs) had been undertaken, demonstrating mucin at the ampullary orifice and a dilated biliary system packed with mucin plugs ([Fig. 1]).