tbuckley/cabot-search huggingface dataset:
Treatment of Coronary Patient with a Pyrimido-Pyrimidine Derivative
Authors: K VUYLSTEEK, R COLLE, M LAURIJSSENS, M VAN DER STRAETEN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular Reactions of Normal and Malignant Tissues &lt;italic&gt;In Vivo&lt;/italic&gt;. VII. Observations on Vascular Reactions in Destruction of Tumor Homografts
Authors: G H ALGIRE
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Vascular Reactions of Normal and Malignant Tissues In Vivo. VII. Observations on Vascular Reactions in Destruction of Tumor Homografts Get access Glenn H. Algire Glenn H. Algire Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 483–491, https://doi.org/10.1093/jnci/15.3.483 Published: 01 December 1954 Article history Received: 06 August 1954 Published: 01 December 1954
Surveillance of human Campylobacter infections in France - Part 1 - Which data? A study of microbiological laboratories, 2000
Authors: A Gallay, F Simon, F. Mégraud
Journal: Eurosurveillance (2003)

The frequency of Campylobacter infections in humans, their potential severity, and the existence of preventive measures justify the implementation of a surveillance system for these infections. Before the implementation of the surveillance system, a survey of the Campylobacter diagnostic practices in the laboratories was performed. In the laboratories that responded, most investigated for Campylobacter at least once in 1999. Identification of the Campylobacter species was carried out by 86% of hospital laboratories and 37% of private laboratories. Antibiotic sensitivity tests were carried out by 75% and 32% of them respectively. Many laboratories test for Campylobacter in stool samples using comparable methods showing the feasibility of a surveillance system.
Alteration of Cellular Oncogene Expression in L1210 Cells by a Nitrosourea Analog of Thymidine
Authors: X K Zhang, M L Zucker, D P Huang, T S Lin, W H Prusoff, J F Chiu
Journal: Cancer Communications (1991)

3'[3-(2-Chloroethyl)-3'nitrosoureido]-3'-deoxythymidine (3'-CTNU), a chloroethylnitrosourea analog of thymidine, is a potent antineoplastic agent against murine leukemia L1210. In this study, we have examined the effects of 3'-CTNU on cellular oncogene (proto-oncogene) expression. We found that the expression of the c-myb proto-oncogene was dramatically enhanced in a concentration- and time-dependent manner by 3'-CTNU in murine leukemia L1210 cells, whereas the expression of the c-myc proto-oncogene was suppressed. The enhancement of c-myb gene expression was found to be cell type-specific and to involve an increase of the c-myb transcription rate rather than an alteration of c-myb gene structure or increased stability of c-myb mRNA. Further analysis demonstrated that the altered c-myb gene expression was largely due to the presence of 3'-amino-3'-deoxythymidine, a decomposition product of 3'-CNTU. The expression of five other proto-oncogenes was unaffected by 3'-CTNU treatment. Our study showed that an antineoplastic agent can increase or decrease the expression of proto-oncogenes.
THU0612-HPR Health Enhancing Physical Activity in Patients with Hip or Knee Osteoarthritis
Authors: A. Ernstgård, M. PirouziFard, C. Thorstensson
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteoarthritis is one of the leading causes to inactivity worldwide (1). Inactivity is a risk factor for progress of osteoarthritis as well as for ill health (2, 3, 4). To maintain good health it is recommended to be physically active at least 150 minutes per week at moderate intensity (2). <h3>Objectives</h3> The purpose of this study was to evaluate how a supported osteoarthritis self-management programme influenced the proportion of patients involved in health enhancing physical activity (HEPA) at 3 and 12 months follow-up, and how level of physical activity was influenced by body mass index (BMI), gender, age and comorbidity among patients with hip or knee osteoarthritis. <h3>Methods</h3> 6810 patients were included in this observational study. HEPA was defined as self-reported physical activity of at least moderate intensity either a) at least 30 minutes per day on 4 days or more per week, or b) at least 150 minutes per week. HEPA was assessed at baseline, and again at 3 and 12 months follow-up. Cochran9s Q test was used to determine change in physical activity over time. The association between level of physical activity and time, age, BMI, sex, and Charnley index were investigated using generalized estimation equation (GEE) model. <h3>Results</h3> The proportion of patients who reached the level of HEPA increased from 77% to 82% from baseline to 3 month follow-up. At 12 months the proportion of patients who reached the level of HEPA was 76%. Not reaching the level of HEPA was associated with overweight, obesity, male gender and Charnley category C, i.e. osteoarthritis in multiple joint sites (hip and knee), or presence of any other disease that affects walking ability. <h3>Conclusions</h3> The supported osteoarthritis self management programme gave a small but for the individual and the society significant effect on the percentage of patients who reached the level of HEPA at 3 months. Improvements were lost after 12 months. Patients with owerweight, obesity, multiple joint sites involved or comorbidities may need additional support to reach or maintain HEPA. <h3>References</h3> Woolf DA, Pfleger B. Burden of major musculoskeletal conditions. Bulletin of the World Health Organization 2003;81(9)646-56. Global recommendations on physical activity for health 2010. World Health Organization [2014-05-25]. Available: http://whqlibdoc.who.int/publications/2010/9789241599979_eng.spdf Esser S, Bailey A. Effects of exercise and physical activity on knee osteoarthritis. Current Pain and Headache Report 2011;15(6):423-30. Brandt KD. Response of joint structures to inactivity and to reloading after immobilization. Arthritis &amp; Rheumatism 2003;49(2):267-71. <h3>Disclosure of Interest</h3> None declared
Desoxypentose Nucleic Acids and Nucleoproteins of Malignant Tissues. II. Physico-Chemical Studies of the Desoxypentose Nucleic Acid of a Transplantable Mouse Lymphoma
Authors: J SHACK, R J JENKINS, J M THOMPSETT
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Desoxypentose Nucleic Acids and Nucleoproteins of Malignant Tissues. II. Physico-Chemical Studies of the Desoxypentose Nucleic Acid of a Transplantable Mouse Lymphoma Get access Joseph Shack, Joseph Shack Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Jenkins, Robert J. Jenkins Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacqueline M. Thompsett Jacqueline M. Thompsett Laboratory of Experimental Oncology, National Cancer Institute2, and the Cancer Research Institute, University of California School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 6, June 1953, Pages 1435–1446, https://doi.org/10.1093/jnci/13.6.1435 Published: 01 June 1953 Article history Received: 19 November 1952 Published: 01 June 1953
PTH-257 Our secca experience, the first in the UK
Authors: S Elzein, C Maxwell-Armstrong
Journal: Gut (2015)

<h3>Introduction</h3> Faecal incontinence (FI) is a debilitating condition, limiting the individual’s social interactions and freedom of movement. Because of the embarrassing nature of faecal incontinence symptoms are often hidden. The management of this condition varies greatly, from a range of conservative measures to surgery. Surgical options have developed over the years, but the general consensus is that it is only used when other options have failed. SECCA (endoscopic temperature controlled radiofrequency energy) was first introduced for the management of FI in 2002. It was marketed as a bridge between conservative and surgical treatment options. <h3>Method</h3> This a retrospective review of 8 patients who have undergone the SECCA procedure at Nottingham Teaching Hospitals for Faecal incontinence. There is no documented review of this procedure in the UK. All were carried out as a day case procedure. All data was collected from patients’ notes. <h3>Results</h3> 10 patients underwent the SECCA procedure; eight female and 2 male with a median age of 67 years (49–80). The notes of 2 of these patients could not be located for this review. 3 patients (37.5%) developed early postoperative complications. One rectal bleeding that resolved spontaneously. One elderly lady developed a CVA. One developed diarrhoea post operatively. There was an improvement in function in 4 of the 8 patients (30%, 25%, 50%, and 75%) at 1, 4, 6 and 13 months follow up respectively at the time of writing this abstract. Three of these patients are not happy with their results. <h3>Conclusion</h3> From the review of our patients it appears SECCA is a relatively safe day case procedure that improves function in approximately 50% of cases (100% of cases if considered only at 6 months post procedure). This review is for a very small number of patients limiting accurate interpretation and <i>generalisation </i>of these findings. Further multicentre observational studies are required. <h3>Disclosure of interest</h3> None Declared.
SP0243 The Microbiome as Determinant for Autoimmune Rheumatic Disease
Authors: J. Scher
Journal: Annals of the Rheumatic Diseases (2015)

Humans and other mammals are not (and have never been) alone. From the moment we are born, millions of microorganisms populate our bodies and coexist with us rather peacefully for the rest of our lives. This massive anitgenic load derived from microorganisms (and their genomes) define the human microbiome. Micro-organisms living in or on us have evolved to extract the energy they require to survive, and in exchange they support the physiological, nutritional, metabolic and immune functions that have contributed to our evolutionary success. Although currently categorized as autoimmune disorders and regarded as complex genetic disease, the ultimate cause of rheumatoid arthritis (RA), psoriatic arthirits (PsA), and related conditions remain elusive. It seems that interplay between predisposing genetic factors and environmental triggers is required for disease manifestations. New insights from DNA sequence- based analyses of gut and skin microbial communities and a renewed interest in mucosal immunology suggest that the microbiome represents an important environmental factor that can modulate inflammation and autoimmune disease manifestations. Multiple animal models and novel human studies suggest a possible role for a disruption in the microbiome composition (dysbiosis) in the pathogenesis of inflammatory arthritis, presumably through activation of proinflammatory T-cells via antigenic molecules and/or bacterial-derived metabolites. <h3>Disclosure of Interest</h3> None declared
Sudden death from acute cocaine intoxication in Virginia in 1988
Authors: R McKelway, V Vieweg, P Westerman
Journal: American Journal of Psychiatry (1990)

A review of medical examiners' autopsy records revealed that in 1988, 33 residents of Virginia died of acute cocaine intoxication. The subjects were 19 to 45 years old; most were men, used cocaine intravenously, and used other toxic substances with the lethal dose of cocaine.
P21 The evaluation of serum ferritin and trasferrin saturation in the diagnosis of haemochromatosis in an ethnically diverse population
Authors: S Al-shamma, S Khaled, P Kennedy, A Provan
Journal: Gut (2010)

Introduction  Hereditary haemochromatosis (HH) is the most common genetic abnormality in populations of Northern European ancestry. There are limited data on the frequency of HFE in populations from the Indian subcontinent. Elevated serum ferritin (Fe) and transferrin saturation (TSAT) are often used as the basis for referral for HFE gene analysis.  Aim  We undertook this study to evaluate the performance of elevated Fe and TSAT in the diagnostic algorithm of HH in a Caucasian population and how it compared when applied to an Indian population.  Method  Data on all patients referred from the gastroenterology service for HFE gene analysis between 2001 and 2009 were evaluated. Serum Fe and TSAT were recorded where available to assess their utility in predicting HFE gene mutations and subsequent requirement for venesection. An estimation of the prevalence of iron overload due to HFE gene mutations in our large Indian population was sought.  Results  307 patients with elevated Fe levels underwent HFE genetic analysis. 146/307 (48%) patients had a TSAT performed at the time of referral. 34/307 (11%) were homozygotes for C282Y mutation, while 18 (6%) were compound heterozygotes. Almost half of those tested 147/307 (48%) had no genetic mutation.  A TSAT >45% was found in 42/146 tested patients. All C282Y/C282Y patients tested had a TSAT >45%, almost a quarter of whom (23.5%) had a TSAT  45% had alcoholic liver disease. The positive predictive value of a TSAT >45% in detecting a C282Y/C282Y or C282Y/H63D mutation was 54.7% compared to 14.5% for ferritin. The negative predictive value of a TSAT >45% in excluding a C282Y/C282Y or C282Y/H63D mutation was 96.2%. 32/307 (10.4%) patients from the Indian sub-continent underwent HFE genetic testing. The mean Fe was 421 with a mean TSAT of 40.3% compared to 564 and 47.7%, respectively, for the Caucasian population (p  Conclusion  TSAT has an excellent NPV and should be an integral part of the diagnostic algorithm for HH, where a cut-off value of 45% detects all C282Y homozygotes, while a higher cut-off value may miss some patients. This translates well into Indian populations. HFE gene mutations are extremely rare in patients of Indian descent and other aetiologies for elevated Fe/TSAT should be sought.
Overview: Ethical issues in contemporary psychiatry
Authors: F Redlich, R F Mollica
Journal: American Journal of Psychiatry (1976)

The authors survey the ethical problems confronting psychiatry today. They state that with rare exceptions psychiatric intervention can be morally justified only with the potential patient's informed consent. Within this framework, they discuss the fact that today nonpsychiatrists, particularly ethicists, lawyers, legislators, and social scientists, as well as psychiatrists are concerned about medical ethics, specifically regarding the right to be treated, the right not to be treated, the civil rights of psychiatric patients, the ethics of behavior control, the problem of conflicts of interest in therapeutic goals, privacy and confidentiality, the ethics of human experimentation, policy decisions, and psychiatry's relationship to the changing moral value structure of U.S. society.
Abstract 11501: Erythrocyte-Rich Thrombus as a Predictor of Angiographic Visible Distal Embolization in Patients with ST-Elevation Myocardial Infarction Treated by Thrombus Aspiration
Authors: Hiroaki Matsumi, Kei Yunoki, Takahiko Naruko, Ryushi Komatsu, Akira Itoh, Kazuo Haze, Kenichi Sugioka, Yoshiki Matsumura, Satoko Wada, Mayumi Inaba, Yoko Iwasa, Minoru Yoshiyama, Makiko Ueda
Journal: Circulation (2011)
Case 43-1962
Authors: Lot B. Page, Benjamin Castleman
Journal: New England Journal of Medicine (1962)

Presentation of Case* First admission. A fifty-year-old man entered the hospital because of edema.Edema involving the ankles and feet and occasionally the face and hands appeared one month previously. Except for mild nocturia the patient was otherwise asymptomatic. On admission to another hospital a markedly elevated serum cholesterol, a low serum protein and ++++ proteinuria were found; the urinary sediment, the serum nonprotein nitrogen and intravenous pyelograms were normal. He was discharged on a low-salt diet, and the edema decreased. There was no history of previous significant illness. A urinalysis performed five months before entry was said to . . .
Therapy-related leukemia associated with high-dose 4-epi-doxorubicin and cyclophosphamide used as adjuvant chemotherapy for breast cancer.
Authors: L Shepherd, J Ottaway, J Myles, M Levine
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.11.2514 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7964967 Therapy-related leukemia associated with high-dose 4-epi-doxorubicin and cyclophosphamide used as adjuvant chemotherapy for breast cancer. L ShepherdxL ShepherdSearch for articles by this author , J OttawayxJ OttawaySearch for articles by this author , J MylesxJ MylesSearch for articles by this author , M LevinexM LevineSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.11.2514 PDF "Therapy-related leukemia associated with high-dose 4-epi-doxorubicin and cyclophosphamide used as adjuvant chemotherapy for breast cancer.." Journal of Clinical Oncology, 12(11), pp. 2514–2515© 1994 by American Society of Clinical Oncology
SAT0513 Brainstem Auditory Evoked Potentials and Visual Potentials in Kawasaki Disease: Expression of CNS Vasculitis?
Authors: M.C. Maggio, C.M. Ministeri, I. Maccora, G. Vitaliti, E. Prinzi, G. Corsello
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Kawasaki disease (KD) is an acute, self-limited vasculitis of infants and children that is nowadays the most common cause of acquired heart disease in children. Transient sensorineural hearing loss (20 to 35 dB) is a possible complication of acute phase KD and may be related to salicylate toxicity in some patients. <h3>Objectives</h3> <i>Brainstem Auditory Evoked Potentials (BAEPs)</i>, and <i>Visual Evoked Potentials (VEPs)</i> were examined in 43 children (age: 0,8-7,5 years) affected by KD. No risk factors for hearing loss and/or neurological impairment of CNS were identified in all the patients. BAEPs showed altered waves II to V, in 18 patients (42%). Among these, in 4 patients (20%) VEPs showed altered waves. <h3>Results</h3> The 18 patients with altered waves of BAEPs were 11 with typical KD, 7 with incomplete KD. Among the 11 patients with altered BAEPs and typical KD, 36% showed coronaritis; among the 7 patients with altered BAEPs and incomplete KD, 57% showed coronaritis. The evaluation of waves VI, VII, interpeak latency V-VII were performed in all the patients and showed a pathological pattern in 72% of altered BAEPs, but also in 68% of patients with normal waves I to V. These waves are expression of neuronal conduction in medial geniculate, acoustic radiations, sign of a lesion of mesencephalon, thalamus and/or acoustic radiations. No correlation was relieved with EVIG doses, days of fever at the start of EVIG, pre-EVIG D-Dimer plasmatic levels, CRP, ESR, leukocytes, neutrophils percentage pre- and post- EVIG. <h3>Conclusions</h3> Altered BAEPs waves are relieved in 81% of KD patients; 70% of KD patients showed altered VI, VII and/or V-VII expression of CNS vasculitis of mesencephalon, thalamus and/or acoustic radiations. Despite normal hearing acuity these children showed a vasculitis of CNS, in 43% of them coronaritis was associated. <h3>References</h3> Knott PD, Orloff LA, Harris JP, Novak RE, Burns JC; Kawasaki Disease Multicenter Hearing Loss Study Group. Sensorineural hearing loss and Kawasaki disease: a prospective study. Am J Otolaryngol. 2001;22(5):343-8. <h3>Disclosure of Interest</h3> None declared
YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells
Authors: Yannick Poitelon, Camila Lopez-Anido, Kathleen Catignas, Caterina Berti, Marilena Palmisano, Courtney Williamson, Dominique Ameroso, Kansho Abiko, Yoonchan Hwang, Alex Gregorieff, Jeffrey L Wrana, Mohammadnabi Asmani, Ruogang Zhao, Fraser James Sim, Lawrence Wrabetz, John Svaren, Maria Laura Feltri
Journal: Nature Neuroscience (2016)
Adult Respiratory Distress Syndrome
Authors: J W Biondi, R L Hines, P G Barash, C C Baker, M A Matthay, R A Matthay
Journal: Annals of Internal Medicine (1992)

The adult respiratory distress syndrome (ARDS) represents a common denominator of acute lung injury leading to alveolar flooding, decreased lung compliance, and altered gas transport. In the absence of specific etiology and therapy, the management of ARDS remains largely supportive. Ubiquitous use of intermittent positive-pressure ventilation with positive end-expiratory pressure (PEEP) improves arterial oxygenation but with some risk of pulmonary barotrauma and decreased cardiac output. The recent understanding of lung inflation as a modulator of right heart afterload and the effect of the right ventricle on global cardiac performance continues to redefine optimal patterns of ventilatory and hemodynamic intervention in ARDS.