tbuckley/cabot-search huggingface dataset:
Autologous Transplantation for Multiple Myeloma in the Era of New Drugs: A Phase III Study of the Intergroupe Francophone Du Myelome (IFM/DFCI 2009 Trial)
Authors: Michel Attal, Valerie Lauwers-Cances, Cyrille Hulin, Thierry Facon, Denis Caillot, Martine Escoffre, Bertrand Arnulf, Margaret MACRO, Karim Belhadj, Laurent Garderet, Murielle Roussel, Claire Mathiot, Herve Avet-Loiseau, Nikhil C. Munshi, Paul G. Richardson, Kenneth C. Anderson, jean Luc Harousseau, Philippe Moreau
Journal: Blood (2015)
P3-051: Correlation with PET-CT/ follow up CT for primary and metastatic lung cancers treated with cryoablation
Authors: Soo-Youn Ham, Sung Ho Lee, Kwang Taik Kim, Yu-Hwan Oh, Sung Bum Cho, Yun Hwan Kim, Sung Eun Kim
Journal: Journal of Thoracic Oncology (2007)
Case 57-1962
Authors: James H. Jandl, Benjamin Castleman
Journal: New England Journal of Medicine (1962)

Presentation of CaseA sixty-year-old man was referred to the hospital because of anemia and thrombocytopenia.The patient sustained a contusion of the nose and a low-back strain in an automobile accident six weeks previously. He was otherwise asymptomatic until two weeks later, when profuse epistaxis for two days required nasal packs. Iron therapy was given orally, but increasing weakness and a loss of 20 pounds in weight began. Two weeks before entry there was a sudden, progressive decrease in vision, beginning in the upper visual fields, accompanied by increasing loss of memory, confusion and disorientation, intermittent headache, orthopnea requiring . . .
Gfi1b-A Novel Tumor Suppressor In Acute Myeloid Leukemia
Authors: Lacramioara Botezatu, Judith Hönes, Amos Zeller, Lars C. Michel, Andre Görgens, Klaus Lennartz, Renata Köster, Bertram Opalka, Bernd Giebel, Ulrich Dührsen, Cyrus Khandanpour
Journal: Blood (2013)
P2-085: Aberrant methylation of RASSF1A in small-sized lung adenocarcinoma and its relationship to clinicopathological features
Authors: Kuniharu Miyajima, Hisashi Saji, Masahiro Tsuboi, Takashi Hirano, Harubumi Kato, Makoto Suzuki, Hisayuki Shigematsu, Riichiro Maruyama, Shinichi Toyooka, Adi F. Gazdar
Journal: Journal of Thoracic Oncology (2007)
Risk Adapted-High Dose Therapies Modulate the Impact of Biological Classification in Diffuse Large B Cell Lymphoma Prognosis. Analysis of Biological Markers in Patients From Clinical Trials in Geltamo and Gotel Spanish Collaborative Groups.
Authors: Santiago Montes-Moreno, Ana Batlle, Sonia Gonzalez de Villambrosia, Beatriz Sanchez-Espiridión, Laura Cereceda, Eva González-Barca, Purroy Noelia, Emilia Pardal, Elena Sebastian, Alejandro Martin, Carlos Grande, Francisco Mazorra, Andrés Insunza, Antonio Rueda, Marta Llanos, Jose Gomez Codina, Francisco Ramon Garcia Arroyo, Dolores Caballero, Eulogio Conde, Andrés Lopez, Mariano Provencio, Miguel Piris
Journal: Blood (2012)
P3-086: Initial safety results from expended access program (EAP) with erlotinib in non small cell lung cancer (NSCLC) in Israel
Authors: Maya Gottfried, Mark Levit, Mirjiana Wollner, Julia Dudnik, Nili Ramu, Dov Flex, Frida Barak, Haim Biran, Arnoldo Cijon, Ofer Merimsky
Journal: Journal of Thoracic Oncology (2007)
PTU-223 Conversion to open surgery from laparoscopy: to ‘try and fail’ or ‘not try at all’?: Abstract PTU-223 Table 1
Authors: RT Pasam, D Estrada Trejo, A Murray, S Lee-Kong, D Feingold, RP Kiran
Journal: Gut (2015)

<h3>Introduction</h3> Clarification as to whether conversion to open surgery during laparoscopic colectomy leads to adverse clinical outcomes when compared to laparoscopic surgery that is completed will help establish if the minimally invasive approach should routinely be attempted in most instances with open surgery reserved for only when this were to fail. <h3>Method</h3> The National Surgery Quality Improvement Program 2012 database was used for analysis of patients who underwent laparoscopic colectomy. Patients were categorised into those who completed laparoscopic procedures, who had laparoscopic procedures with conversion to open, and who had open procedures. Analysis was carried out using chi-squared test, fisher exact test, and logistic regression. <h3>Results</h3> Of the 16,648 patients included, 7409 (44.50%) underwent open surgery. Of the 9239 who underwent laparoscopic colectomy, 1147 (12.41%) had conversion to open procedure. Strongest association with conversion was found with emergency procedures, preoperative sepsis and septic shock. The other associated factors were male sex, history of CHF, COPD, hypertension, steroid use and disseminated cancer. Post-operatively, compared to the patients who had laparoscopic procedure those who had conversion to open procedure had a higher risk of surgical and medical complications (see Table 1). However, when compared to patients who completed open surgery straightaway, patients who had conversion to open surgery had a higher risk for superficial SSI. While other complications were comparable to open surgery, converted patients had a lower risk of post-operative pneumonia, re-intubation, need for ventilation &gt; 48 h, bleeding that required transfusion, sepsis, septic shock and return to the operating room. <h3>Conclusion</h3> While patients who have open conversion have worse outcomes than those who complete laparoscopic colectomy, outcomes for converted patients are not significantly worse than for comparable patients who undergo open surgery straightaway. Considering the benefits of the minimally invasive approach, laparoscopic colectomy may reasonably be attempted in any patient, even when completion may not be assured, with conversion reserved for when this is not feasible. <h3>Disclosure of interest</h3> None Declared.
Botulinum Toxin Injection as a Diagnostic Tool for Verification of Sphincter of Oddi Dysfunction Causing Recurrent Pancreatitis
Authors: S M Muehldorfer, E G Hahn, C Ell
Journal: Endoscopy (1997)

Sphincter of Oddi dyskinesia (SOD) is among the less frequent causes of acute recurrent pancreatitis. We report on a patient with frequent pain attacks accompanied by pancreatic enzyme elevation, in whom a transitory decrease of the SO pressure following endoscopic botulinus toxin injection was a diagnostic clue for SOD. The patient's symptoms resolved for 4 months, after which time recurrent symptoms paralleled the reoccurrence of the elevated SO pressure. Endoscopic sphincterotomy of the biliary sphincter relieved her symptoms for the subsequent follow-up period which is now 10 months.
Abstract 13444: Longer Telomere Length is Associated With More Distensible Carotid Arteries in a Healthy Adult Population
Authors: Dhananjay Vaidya, Lisa R Yanek, Kruthika R Iyer, Margaret A Taub, Rita R Kalyani, Brian G Kral, Diane M Becker, Lewis C Becker, Rasika A Mathias
Journal: Circulation (2015)

Introduction: Chronological age is associated with loss of arterial distensibility leading to greater cardiac afterload and inefficient systemic perfusion. It is not known if cellular aging, marked by a loss of telomeres, underlies vascular aging. We thus examined the association of leukocyte telomere length (LTL) with common carotid distensibility (CD) in a healthy adult population. Methods: We analyzed data from 119 adults free of clinical cardiovascular disease (ages 21-80 years, 39% African American, 60% women, from 99 families) with familial history of early onset coronary artery disease (30x coverage, Illumina HiSeq) for both 4 (LTL4) and 7 (LTL7) contiguous telomere motif repeats (TTAGGG or CCCTAA) using the approach of Ding et al (2014). Mean CD of both carotid arteries was calculated from systolic and diastolic carotid diameters measured using B-mode ultrasound and simultaneous measurement of brachial artery pulse pressure (follow-up time 0-5 years from the LTL visit). We used mixed model regression to account for non-independence of data in families. Results: The mean (SD) of LTL4 was 94851 (16370) and of LTL7 was 80666 (15001) repeats. Adjusting for age at LTL measurement, follow-up time to carotid measurement, sex, race, systolic and diastolic blood pressure, LDL- and HDL-cholesterol levels, current smoking and diabetes, 1 SD higher level of LTL4 was associated with 2.0 х 10 -4 (p = 0.027), and 1 SD higher level of LTL7 with 1.8 х 10 -4 mmHg -1 (p = 0.048) higher CD, which is equivalent to CD at a chronological age that is lower by 4.4 and 4.0 years, respectively. Hypertension is not significantly associated with CD (p = 0.49) when added to this model. Conclusions: Greater LTL is associated with more distensible carotid arteries independent of cardiac risk factors including chronological age and blood pressure. Preserved telomere length represents healthy cellular aging in terms of fewer cell divisions, and thus greater vascular reparative reserve, which may lead to preserved arterial distensibility. This mechanism may partly explain the reported association of greater telomere length with lower risk of vascular events including coronary disease, heart failure and stroke.
Randomized, open-label study of pemetrexed/carboplatin followed by maintenance pemetrexed versus paclitaxel/carboplatin/bevacizumab followed by maintenance bevacizumab in patients with advanced non-small cell lung cancer (NSCLC) of nonsquamous histology.
Authors: R. Zinner, S. Saxman, G. Peng, W. F. Ortuzar
Journal: Journal of Clinical Oncology (2010)

TPS290 Background: Pemetrexed plus carboplatin and paclitaxel plus carboplatin and bevacizumab are active regimens in the first-line treatment of patients with advanced NSCLC and nonsquamous histology. While the combinations have never been directly compared, data suggest these treatment regimens may have similar efficacy but toxicity may be reduced with the pemetrexed combination (Scagliotti, Clin Cancer Res, 2005; Zinner, Cancer, 2005; Johnson, JCO, 2004). Methods: An ongoing, multicenter, open-label study is currently accepting participants with nonsquamous NSCLC (stage IV by AJCC version 7), measurable disease by RECIST, age ≥18 years, adequate organ function, and stable brain metastases. Patients will be randomized to receive either pemetrexed 500 mg/m2 plus carboplatin AUC 6 for 4 cycles followed by maintenance pemetrexed 500 mg/m2 (Arm A) or paclitaxel 200 mg/m2 plus carboplatin AUC 6 plus bevacizumab 15 mg/kg for 4 cycles followed by maintenance bevacizumab 15 mg/kg (Arm B). All cycles are repeated once every 3 weeks. Primary endpoint is progression- free survival (PFS) without grade 4 toxicity (G4PFS) and will test the hypothesis that G4PFS is superior for the pemetrexed-containing combination. This type of endpoint has been utilized previously in clinical trials in which survival outcomes have been shown to be similar between treatment regimens and thus a regimen that reduces the risk of toxicity is clinically relevant, particularly in the palliative setting (Scagliotti, Eur J Cancer, 2009; Pujol, J Thorac Oncol, 2007). A gatekeeper strategy will sequentially test PFS. Enrollment: approximately 360 patients (180 per arm), allowing for 10% drop-out. The final analysis of G4PFS will be performed after 299 events have occurred. Assuming a hazard ratio (HR) of 0.75, this study will have 80% statistical power to detect superiority of Arm A arm over Arm B with a one-sided log-rank test and a type I error of 0.05. If the true median G4PFS for Arm B is 3 months, then the HR of 0.75 amounts to an approximately 1-month improvement in median G4PFS for Arm A. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Lilly Lilly Lilly Lilly Lilly
Early menopause is linked to higher risk of cardiovascular disease and death, review finds
Authors: Susan Mayor
Journal: BMJ (2016)

Women who experience premature or early onset menopause before age 45 have a 50% higher risk of coronary heart disease and nearly a 25% higher risk of cardiovascular death than those whose menopause occurs later, a review has found.1

The meta-analysis reviewed 32 observational studies including 310 329 women, comparing outcomes in women who experienced …
Abstract 12903: The Myocardial Contraction Fraction Calculated From Two-dimensional Echocardiography is Associated With Lower Incidence of Heart Failure, Cardiovascular Disease and Mortality: The Cardiovascular Health Study
Authors: Mathew S Maurer, William Jen Hoe Koh, Traci M Bartz, Sirish Vullaganti, Eddy Barasch, Julius M Gardin, John S Gottdiener, Bruce M Psaty, Jorge R Kizer
Journal: Circulation (2015)

Introduction: The myocardial contraction fraction (MCF), the ratio of LV stroke volume (SV) to myocardial volume (MV), is a volumetric measure of myocardial shortening. With 3D-echocardiography and MRI, MCF distinguished pathologic from physiologic hypertrophy and predicted incident CV events. However, the association between 2D echo-determined MCF and adverse CV outcomes is not known, nor has the premise that this ratio adequately captures the predictive information of its components, SV and MV, been tested. Methods: Using CHS data, we calculated MCF from 2-D guided M-mode echo dimensions to estimate LV volumes and SV. MV was estimated from the measurements of LV mass divided by myocardial density. Among individuals with a normal EF, Cox regression was used to examine the associations between MCF with incident heart failure (HF), cardiovascular disease (CVD), and all-cause mortality adjusting for clinical and echo parameters. We further examined the validity of the premise that log(SV) and log(MV) contribute in the expected ratio of 1: -1 with our outcomes of interest. Results: 1556 participants were identified with an EF ≥ 55% (age 72±5) that had baseline echo data and available covariate information. MCF averaged 58% (Range: 21-104%). After controlling for CV, clinical risk factors, echo variables and NT-proBNP, a 10% relative increase in MCF was significantly associated with reduced risk of HF, CVD and death. When included separately in the models, both MV and SV showed significant associations with CVD and death, however, only MV was significant for HF and the coefficients violated the 1:-1 ratio suggesting MCF is not the best way to model this relationship. Conclusions: Among older adults with normal EF, 2D-echo MCF was associated with a lower risk of adverse CV outcomes after adjustment for clinical factors, echo parameters, and NT-proBNP. However, MCF compared to its component measures might be inadequate for risk prediction in HF.
P1-051: Survival of lung cancer patients is better in 2000-5 than 1990-5 cohorts: a french monocentric experience
Authors: Fabien Vaylet, René Jancovici, Claude Marotel, Jacques Margery, Alexa Mairovitz, Elsie Staub, Yvan Salles, Augustin Bonnichon, Frederic Riviere, Herve Lefloch
Journal: Journal of Thoracic Oncology (2007)
Harnessing Nanoparticles for Immune Modulation
Authors: Daniel R. Getts, Lonnie D. Shea, Stephen D. Miller, Nicholas J.C. King
Journal: Trends in Immunology (2016)

Due to an oversight in the preparation of this Review article, the authors inadvertently included a "rat" model for "Complete LAD occlusion" in Table 1. Findings on "Japanese encephalitis" were erroneously attributed to reference 8 but are unpublished observations. Table 1 was modified to reflect those changes and the corrected version is included below. That authors apologize for these errors and assert that they make no difference to the line of discussion of this review.
P1-249: Anemia rates in completely resected non-small cell lung cancer (NSCLC) patients receiving adjuvant chemotherapy; An interim analysis
Authors: Ronald Feld, Rafal Wierzbicki, David Walde, Cynthia Card, David Small, Richard K. Plante, Deepka Sharma, Fernando Camacho
Journal: Journal of Thoracic Oncology (2007)
Continuous glucose monitoring for patients with type 1 diabetes and impaired awareness of hypoglycaemia (IN CONTROL): a randomised, open-label, crossover trial
Authors: Cornelis A J van Beers, J Hans DeVries, Susanne J Kleijer, Mark M Smits, Petronella H Geelhoed-Duijvestijn, Mark H H Kramer, Michaela Diamant, Frank J Snoek, Erik H Serné
Journal: The Lancet Diabetes & Endocrinology (2016)
Return to play: the challenge of balancing research and practice
Authors: Alan McCall, Colin Lewin, Gary O'Driscoll, Erik Witvrouw, Clare Ardern
Journal: British Journal of Sports Medicine (2016)

Life is full of risky decisions, from mundane ones, to matters of life and death.1 In professional football, risk is everywhere: For the club—the risk of having a poor season and loss of income by not qualifying for an important competition. For the manager—overseeing a bad run of results, potentially jeopardising his position. For the player—poor performance and, of course, injury. For the medical/science team—bringing a player back too early from musculoskeletal injury, and he/she suffering a reinjury. The dilemma is that, usually, riskier options promise higher returns.1

In football, the decision to progress or delay a player's return to play (RTP) after musculoskeletal injury could be the difference between having a key player back two games earlier (giving the best chance to earn six points) contrasted with keeping the player out for two extra games, lowering his/her reinjury risk, but potentially ending up with fewer points. Which risk is more important? Do we aim for a reinjury rate of 0%? Or might we settle for 10% recurrence, where every injured player is back one game earlier?

RTP has been prominent …
P3-140: Erlotinib treatment after progression on gefitinib in non-small cell lung cancer(NSCLC)
Authors: Sung Hoon Sim, Sae-Won Han, So Yeon Oh, Hye Jin Kim, Yu Jung Kim, Se-Hoon Lee, Dong-Wan Kim, Dae Seog Heo
Journal: Journal of Thoracic Oncology (2007)
Climate and Health Co-Benefits in Low-Income Countries: A Case Study of Carbon Financed Water Filters in Kenya and a Call for Independent Monitoring
Authors: Amy J. Pickering, Benjamin F. Arnold, Holly N. Dentz, John M. Colford, Clair Null
Journal: Environmental Health Perspectives (2016)

The recent global climate agreement in Paris aims to mitigate greenhouse gas emissions while fostering sustainable development and establishes an international trading mechanism to meet this goal. Currently, carbon offset program implementers are allowed to collect their own monitoring data to determine the number of carbon credits to be awarded.We summarize reasons for mandating independent monitoring of greenhouse gas emission reduction projects. In support of our policy recommendations, we describe a case study of a program designed to earn carbon credits by distributing almost one million drinking water filters in rural Kenya to avert the use of fuel for boiling water. We compare results from an assessment conducted by our research team in the program area among households with pregnant women or caregivers in rural villages with low piped water access with the reported program monitoring data and discuss the implications.Our assessment in Kenya found lower levels of household water filter usage than the internal program monitoring reported estimates used to determine carbon credits; we found 19% (n = 4,041) of households reported filter usage 2-3 years after filter distribution compared to the program stated usage rate of 81% (n = 14,988) 2.7 years after filter distribution. Although carbon financing could be a financially sustainable approach to scale up water treatment and improve health in low-income settings, these results suggest program effectiveness will remain uncertain in the absence of requiring monitoring data be collected by third-party organizations.Independent monitoring should be a key requirement for carbon credit verification in future international carbon trading mechanisms to ensure programs achieve benefits in line with sustainable development goals. Citation: Pickering AJ, Arnold BF, Dentz HN, Colford JM Jr., Null C. 2017. Climate and health co-benefits in low-income countries: a case study of carbon financed water filters in Kenya and a call for independent monitoring. Environ Health Perspect 125:278-283; http://dx.doi.org/10.1289/EHP342.
477TiP Phase IV study of afatinib as second-line therapy for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring common epidermal growth factor receptor (EGFR) mutations (Del19 and/or L858R)
Authors: S. Thongprasert, A. Alexandru, M. Schenker, A. Abdelaziz, D. Clement, C. Boldeanu, D. Jovanovic, J. Reyes-Igama, M. Petrović, S. Geater, D. Radosavljevic, B. Perin, M. Krzakowski, P. Serwatowski, J. Parra, V. Sriuranpong, H. Jones, A. Cseh, R. Gaafar
Journal: Annals of Oncology (2015)
Aspirin therapy in cancer patients with acute coronary syndrome and thrombocytopenia
Authors: M. G. Sarkiss, M. Vooletich, G. Botz, A. Shaw, J.-B. Durand
Journal: Journal of Clinical Oncology (2004)

8110 Background: M. D. Anderson Cancer Center encounters patients in whom thrombocytopenia and acute coronary syndrome (ACS) coexist. The current guidelines for the treatment of ACS in patients with normal platelet counts indicate Aspirin (ASA) therapy with reported reduction in mortality rate of 50%. There are, however, no guidelines for ASA therapy in cancer patients with ACS and thrombocytopenia, and ASA is usually withheld because of the risk for bleeding. Methods: Medical records of all patients diagnosed with ACS during 2001 at our institute were evaluated. Patients were divided into two groups: Group A, platelet count > 100 × 109/L, and group B, with platelet count ≤ 100 × 109/L. ASA treatments, the incidence of bleeding, and mortality rates for each group was analyzed. Results: The incidence of patients with ACS and thrombocytopenia was 39%. The severity of MI was not significantly different between the two groups. Group B patients not given ASA treatment had mortality rate of 94% within the first week of myocardial infarction (MI) that decreased to 10% with ASA treatment. Moreover the incidence of bleeding in thrombocytopenic patients taking ASA was 50% with no severe bleeding reported. Patients with normal platelet counts who were treated with ASA also had a13% mortality compared with 55% mortality in those denied ASA. Conclusion: One third of patients diagnosed with ACS at M. D. Anderson Cancer Center had a concomitant thrombocytopenia, which was associated with higher mortality rate. ASA therapy significantly reduced mortality rate in these patients with an acceptable rate of mild to moderate bleeding that was managed adequately with blood transfusion. Moreover, these patients had no significant gastrointestinal or intracranial bleeding events. No significant financial relationships to disclose.