tbuckley/cabot-search huggingface dataset:
Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion
Authors: Felix Knauf, Robert B. Thomson, John F. Heneghan, Zhirong Jiang, Adedotun Adebamiro, Claire L. Thomson, Christina Barone, John R. Asplin, Marie E. Egan, Seth L. Alper, Peter S. Aronson
Journal: Journal of the American Society of Nephrology (2016)

Patients with cystic fibrosis have an increased incidence of hyperoxaluria and calcium oxalate nephrolithiasis. Net intestinal absorption of dietary oxalate results from passive paracellular oxalate absorption as modified by oxalate back secretion mediated by the SLC26A6 oxalate transporter. We used mice deficient in the cystic fibrosis transmembrane conductance regulator gene (Cftr) to test the hypothesis that SLC26A6-mediated oxalate secretion is defective in cystic fibrosis. We mounted isolated intestinal tissue from C57BL/6 (wild-type) and Cftr-/- mice in Ussing chambers and measured transcellular secretion of [14C]oxalate. Intestinal tissue isolated from Cftr-/- mice exhibited significantly less transcellular oxalate secretion than intestinal tissue of wild-type mice. However, glucose absorption, another representative intestinal transport process, did not differ in Cftr-/- tissue. Compared with wild-type mice, Cftr-/- mice showed reduced expression of SLC26A6 in duodenum by immunofluorescence and Western blot analysis. Furthermore, coexpression of CFTR stimulated SLC26A6-mediated Cl--oxalate exchange in Xenopus oocytes. In association with the profound defect in intestinal oxalate secretion, Cftr-/- mice had serum and urine oxalate levels 2.5-fold greater than those of wild-type mice. We conclude that defective intestinal oxalate secretion mediated by SLC26A6 may contribute to the hyperoxaluria observed in this mouse model of cystic fibrosis. Future studies are needed to address whether similar mechanisms contribute to the increased risk for calcium oxalate stone formation observed in patients with cystic fibrosis.
Relation of Duration of a Transplanted Sarcoma to Metastasis in the Hamster&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Edward D. Crabb, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Relation of Duration of a Transplanted Sarcoma to Metastasis in the Hamster Get access Edward D. Crabb, Ph.D. Edward D. Crabb, Ph.D. Department of Biology, University of Colorado, Boulder, Colo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 581–595, https://doi.org/10.1093/jnci/10.3.581 Published: 01 December 1949 Article history Received: 08 June 1949 Published: 01 December 1949
LG-32RHABDOID COMPONENT EMERGING AS A SUBCLONAL EVOLUTION OF PEDIATRIC GLIONEURONAL TUMORS
Authors: Amandine Bertrand, Camille Rondenet, Julien Masliah-Planchon, Pierre Leblond, Arnaud de la Fouchardière, Daniel Pissaloux, Khadija Ait Rais, Delphine Lequin, Anne Jouvet, Matthieu Delion, Matthieu Vinchon, Stephanie Puget, Paul Freneaux, Henri Sevestre, Clemence Delteil, Dominique Ranchere-Vince, Ludovic Lacroix, Arnault Tauziede-Espariat, Nathalie Boddaert, Claude-Alain Maurage, Karen Silva, Sophie Michalak, Gaelle Pierron, Olivier Delattre, Pascale Varlet, Didier Frappaz, Franck Bourdeaut
Journal: Neuro-Oncology (2016)
Effect of Glutamine on the Growth and Metabolism of Liver Cells &lt;italic&gt;in Vitro&lt;/italic&gt;
Authors: B. B. Westfall, V. J. Evans, Ellison V. Peppers, Naomi M. Hawkins, W. R. Earle
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Effect of Glutamine on the Growth and Metabolism of Liver Cells in Vitro Get access B. B. Westfall, B. B. Westfall Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar V. J. Evans, V. J. Evans Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellison V. Peppers, Ellison V. Peppers Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Naomi M. Hawkins, Naomi M. Hawkins Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar W. R. Earle W. R. Earle Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 2, August 1956, Pages 131–138, https://doi.org/10.1093/jnci/17.2.131 Published: 01 August 1956 Article history Received: 14 February 1956 Published: 01 August 1956
Assessing B Lymphocyte Clonal Diversity, Expansion, and Convergent Evolution By High-Throughput Sequencing Of Rearranged IGH Segments From Naïve and Memory Repertoires
Authors: William S DeWitt, Paul Lindau, Ryan O Emerson, Anna Sherwood, David Williamson, Mark J Rieder, Moon Chung, Christopher S Carlson, Harlan Robins
Journal: Blood (2013)
LG-45DISSEMINATED LOW GRADE GLIOMAS IN CHILDREN (DLGG)- ONE INSTITUTION EXPERIENCE
Authors: Iwona Filipek, Monika Drogosiewicz, Marta Perek-Polnik, Ewa Swieszkowska, Wieslawa Grajkowska, Elzbieta Jurkiewicz, Marcin Roszkowski, Bozenna Dembowska-Baginska
Journal: Neuro-Oncology (2016)
Association of Early-Life Antibiotic Use and Protective Effects of Breastfeeding
Authors: Katri Korpela, Anne Salonen, Lauri J. Virta, Riina A. Kekkonen, Willem M. de Vos
Journal: JAMA Pediatrics (2016)

Long duration of breastfeeding is known to reduce the frequency of infections and the risk of overweight, both of which are prevalent health problems among children, but the mechanisms are unclear.To test whether early-life antibiotic use in children prevents the beneficial long-term effects of breastfeeding on weight development and lifetime antibiotic use, and to investigate whether the duration of breastfeeding is associated with long-term microbiota development.Retrospective cohort study, conducted from June 2015 to December 2015, of the association between the duration of breastfeeding and lifetime antibiotic use by children as well as body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) z score in a cohort of 226 healthy children aged 2 to 6 years attending day care at the study area in northern Finland and participating in a probiotic trial from October 1, 2009, through April 30, 2010. Fecal microbiota composition analysis was performed in a subcohort of 42 of these children.Duration of breastfeeding and the number of different antibiotic courses purchased for the child.The BMI z score, lifetime antibiotic use after weaning, and fecal microbiota composition.A total of 226 children (mean [SD] age, 55 [1.4] months; 54% male) were included in the study. Among the 113 children with no antibiotics before weaning, each month of breastfeeding decreased the mean number of postweaning antibiotic courses by 5% (95% CI, 2% to 8%; P = .001) and mean BMI z scores by 0.08 unit (95% CI, 0.04 to 0.11; P < .001). Among the 113 early-life antibiotic users, the effect of breastfeeding on postweaning antibiotic use was borderline significant (estimated 4% decrease per month; 95% CI, 0% to 7%; P = .04) and the effect on BMI z score disappeared (estimated 1% increase; 95% CI, -3% to 5%; P = .50). In the subcohort of 42 children with fecal microbiota composition analysis, the children with short breastfeeding duration (0-6 months) and no early-life antibiotic use or with long breastfeeding duration (8-16 months) and early-life use of antibiotics had a significantly lower abundance of Bifidobacterium (by 55%; 95% CI, 43% to 87%; P = .006; and 39%, 95% CI, 30% to 68%; P < .001, respectively) and Akkermansia (by 71%; 95% CI, 28% to 87%; P = .008; and 69%; 95% CI, 22% to 90%; P = .02, respectively) compared with those with long duration of breastfeeding and no early-life antibiotics.Antibiotic use in a child during breastfeeding may weaken the beneficial effects of long breastfeeding duration. The results suggest that particularly the long-term metabolic benefits of breastfeeding are conveyed by the intestinal microbiota.
Perimenopause: Beginning of Menopause
Authors: Janet M. Torpy, Cassio Lynm, Richard M. Glass
Journal: JAMA (2003)

Perimenopause: Beginning of MenopauseM enopause (the change of life) is when women stop menstruating (having periods) and their ovaries gradually stop working.The time leading up to menopause is called perimenopause.Perimenopause is a transition period in a woman's life and signals the beginning of the loss of fertility (ability to become pregnant) because of the body's natural aging process.Perimenopause and menopause are not diseases.They are healthy and natural parts of a woman's life.Sometimes menopause does not happen naturally but is a result of medical treatments for health problems.Cancer treatments, including chemotherapy, pelvic radiation, and surgery, can cause early menopause.Removal of both ovaries (bilateral oophorectomy) for any reason starts menopause.Having a hysterectomy alone (removal of only the uterus, not the ovaries) does not cause menopause but will stop a woman's menstrual periods.Medical studies have shown that having a hysterectomy may speed the start of natural menopause by 1 to 2 years.Menopause usually happens between the ages of 40 and 55 years.Earlier natural menopause is more common in women who smoke, women who have had a hysterectomy without ovary removal, and women whose mothers and sisters have had earlier menopause.Most women experience hot flashes, which can last for 1 to 30 minutes but are usually 2 or 3 minutes long.Some women may have hot flashes for several years, and other women only have them for a short time.The February 19, 2003, issue of JAMA includes an article about perimenopause and menopause.
Formation of Ketopentoses, Beginning With Ribose-5-Phosphate, in the Serum of Patients With Cancer&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Alberto Cazorla, M.D., Daniel Loayza
Journal: JNCI Journal of the National Cancer Institute (1960)

We have studied the formation of ketopentoses, starting with ribose-5-phosphate, in the serum of 98 normal individuals, 15 patients with nonmalignant diseases, and 104 patients with malignant neoplasias in the different stages of evolution. The results indicated that the activity of the enzymes which intervene in the reaction tends to be greater in the serum of patients with malignant neoplasias, a tendency which becomes even greater in patients with advanced metastatic cancer. Serum of the group with acute leukemia showed evident difference from that of the control group, and gave higher maximum normal values. These results are discussed from the point of view of diagnosis and evolution of the malignant neoplasias.
Clinical implications of DSM-III diagnoses of alcohol abuse and alcohol dependence
Authors: M A Schuckit, S Zisook, J Mortola
Journal: American Journal of Psychiatry (1985)

The authors explored the clinical significance of the DSM-III distinction between alcohol abuse and alcohol dependence by studying 403 male primary alcoholics consecutively admitted to an inpatient alcohol treatment program. On intake, 186 men met criteria for alcohol abuse and 217 met criteria for alcohol dependence. The two groups were virtually identical except that subjects with alcohol dependence took more drinks per drinking day and had more alcohol-related medical problems and past hospitalizations. During a 1-year follow-up, men with alcohol dependence were more likely to have visited a public detoxification facility. The results do not support prognostic implications for the differentiation between alcohol abuse and alcohol dependence in alcoholic inpatients.
Abstract 741: Larger Saphenous Vein Grafts in Relation to Native Artery are Associated with Reduced TIMI Grade 3 Flow but Improved Myocardial Perfusion at 1 Year: A PREVENT IV Analysis
Authors: Lauren N Ciaglo, Dimitri Karmpaliotis, Vijayalakshmi Kunadian, William J Gibson, Jacqueline L Buros, Cafer Zorkun, Michelle E Lew, Robert A Harrington, Alexandra M Palmer, Katherine J Ogando, Leah H Biller, Erin E Lord, Scott P Williams, Susan J Marble, John H Alexander, C. M Gibson
Journal: Circulation (2008)

SVG patency is lower with smaller recipient vessel size (&lt;2mm). However, the relationship between the presence of an over-sized or under-sized SVG relative to the native artery (NA) diameter at follow-up has not been fully explored. It was hypothesized that the presence of a larger SVG to NA diameter at 1 year follow-up would be associated with inferior antegrade flow in SVG and NA. Methods : Data were drawn from the PREVENT IV trial, a phase III, multicenter, randomized, double-blind, placebo-controlled trial in which autologous SVGs were treated ex vivo with edifoligide for patients undergoing CABG with repeat angiography within 18 months post CABG and films were evaluated by a core laboratory for SVG diameter, TIMI flow grade (TFG), TIMI frame counts (TFCs) and TIMI myocardial perfusion grade (TMPG). Results: The average ratio of SVG to NA diameter was 1.71±0.45 (n=1,945 in 1,203 patients). As the ratio of the SVG to NA diameter increased, the occurrence of optimal TFG 3 in the SVG was lower (Figure A ) and TFCs were higher (p=0.0001). The frequency of TFG 3 in the NA artery was also lower as the degree of mismatch between SVG and NA diameter increased (p=0.028). Conversely, as the SVG to NA mean diameter ratio increased, the occurrence of TMPG 3 was higher (Figure B ). Conclusion: Larger SVGs in relation to NA at 1 year follow-up were associated with slower flow but improved myocardial perfusion. Greater SVG diameter may be reflective of a larger SVG volume and may explain in part the longer time to fill the SVG; likewise the larger volume of the SVG may explain the apparent improved perfusion of the myocardium. Slower dye transit in large SVGs does not necessarily imply poor perfusion.
Staphylococcal serine protease–like proteins are pacemakers of allergic airway reactions to Staphylococcus aureus
Authors: Sebastian Stentzel, Andrea Teufelberger, Maria Nordengrün, Julia Kolata, Frank Schmidt, Koen van Crombruggen, Stephan Michalik, Jana Kumpfmüller, Sebastian Tischer, Thomas Schweder, Michael Hecker, Susanne Engelmann, Uwe Völker, Olga Krysko, Claus Bachert, Barbara M. Bröker
Journal: Journal of Allergy and Clinical Immunology (2016)

A substantial subgroup of asthmatic patients have "nonallergic" or idiopathic asthma, which often takes a severe course and is difficult to treat. The cause might be allergic reactions to the gram-positive pathogen Staphylococcus aureus, a frequent colonizer of the upper airways. However, the driving allergens of S aureus have remained elusive.We sought to search for potentially allergenic S aureus proteins and characterize the immune response directed against them.S aureus extracellular proteins targeted by human serum IgG4 were identified by means of immunoblotting to screen for potential bacterial allergens. Candidate antigens were expressed as recombinant proteins and used to analyze the established cellular and humoral immune responses in healthy adults and asthmatic patients. The ability to induce a type 2 immune response in vivo was tested in a mouse asthma model.We identified staphylococcal serine protease-like proteins (Spls) as dominant IgG4-binding S aureus proteins. SplA through SplF are extracellular proteases of unknown function expressed by S aureus in vivo. Spls elicited IgE antibody responses in most asthmatic patients. In healthy S aureus carriers and noncarriers, peripheral blood T cells elaborated TH2 cytokines after stimulation with Spls, as is typical for allergens. In contrast, TH1/TH17 cytokines, which dominated the response to S aureus α-hemolysin, were of low concentration or absent. In mice inhalation of SplD without adjuvant induced lung inflammation characterized by TH2 cytokines and eosinophil infiltration.We identify Spls as triggering allergens released by S aureus, opening prospects for diagnosis and causal therapy of asthma.
The insanity defense: a tale of two cities
Authors: I N Perr
Journal: American Journal of Psychiatry (1983)

The M'Naghten case and the Hinckley matter are in some ways remarkably similar. The attempted assassination of a ruling figure, the public discomfort with the insanity defense, and problems in the application of the legal rules characterized both. An explosion of media criticism occurred in 1843, as it did in 1982. The English ultimately handled the M'Naghten case in a dispassionate manner that determined Anglo-American law for more than a century and provided the basic law by which Hinckley was tried. Fears expressed in 1843 were never realized; the final chapters of the Hinckley case remain to be written.
Endothelial Cells Expressing Endothelial and Mesenchymal Cell Gene Products in Lung Tissue From Patients With Systemic Sclerosis–Associated Interstitial Lung Disease
Authors: Fabian A. Mendoza, Sonsoles Piera‐Velazquez, John L. Farber, Carol Feghali‐Bostwick, Sergio A. Jiménez
Journal: Arthritis & Rheumatology (2015)

To examine whether lung endothelial cells (ECs) from patients with systemic sclerosis (SSc)-associated interstitial lung disease (ILD) express mesenchymal cell-specific proteins and gene transcripts, indicative of the occurrence of endothelial-to-mesenchymal phenotypic transition (EndoMT).Lung tissue from 6 patients with SSc-associated pulmonary fibrosis was examined by histopathology and immunohistochemistry. Confocal laser microscopy was utilized to assess the simultaneous expression of EC and myofibroblast molecular markers. CD31+CD102+ ECs were isolated from the lung tissue of 2 patients with SSc-associated ILD and 2 normal control subjects, and the expression of EC and mesenchymal cell markers and other relevant genes was analyzed by quantitative polymerase chain reaction, immunofluorescence microscopy, and Western blotting.Immunohistochemical staining revealed cells expressing the EC-specific marker CD31 in the subendothelial, perivascular, and parenchymal regions of the lungs from all SSc patients. Confocal microscopy identified cells displaying simultaneous expression of von Willebrand factor and α-smooth muscle actin in small and medium-sized arterioles in the SSc lung tissue but not in normal control lungs. CD31+CD102+ ECs isolated from SSc lungs expressed high levels of mesenchymal cell-specific genes (type I collagen, type III collagen, and fibronectin), EC-specific genes (type IV collagen and VE-cadherin), profibrotic genes (transforming growth factor β1 and connective tissue growth factor), and genes encoding EndoMT-related transcription factors (TWIST1 and SNAI2).Cells coexpressing EC- and mesenchymal cell-specific molecules are present in the lungs of patients with SSc-associated ILD. CD31+CD102+ ECs isolated from SSc lungs simultaneously expressed mesenchymal cell- and EC-specific transcripts and proteins. Collectively, these observations demonstrate the occurrence of EndoMT in the lungs of patients with SSc-associated ILD.
Multicenter randomized study comparing cyclosporine-A alone and antithymocyte globulin with prednisone for treatment of severe aplastic anemia
Authors: E Gluckman, H Esperou-Bourdeau, A Baruchel, M Boogaerts, J Briere, D Donadio, G Leverger, M Leporrier, J Reiffers, M Janvier
Journal: Blood (1992)
MB-02CONTRAST ENHANCEMENT PATTERN IS ASSOCIATED WITH MOLECULAR TYPE OF MEDULLOBLASTOMA TUMOURS AND PREDICTS POOR SURVIVAL FOR PATIENTS
Authors: Maria Łastowska, Elżbieta Jurkiewicz, Joanna Trubicka, Monika Drogosiewicz, Marta Perek-Polnik, Wiesława Grajkowska, Ewa Matyja, Bożenna Dembowska-Bagińska
Journal: Neuro-Oncology (2016)
Pancreatic cancer in breast cancer patients: Incidence and relation with hormone receptor status
Authors: B. Ghabache, J. Cole, S. Vasireddy
Journal: Journal of Clinical Oncology (2007)

17079 Background: There has been a long-standing interest in the role of estrogens in pancreatic tumors and several reports regarding the expression of hormone receptors in pancreatic tumors and the relation between estrogen stimulation and the development of pancreatic cancer have been inconsistent . This raised questions about the increased risk of pancreatic cancer among breast cancer survivors and the possible role of antihormonal therapy in the prevention and treatment of these malignancies. Methods: The Tumor registry at the Ochsner Clinic Foundation in New Orleans was queried to identify new cases of pancreatic cancer among patients previously diagnosed with breast cancer. This was done by matching data on pancreatic and breast cancer diagnosed between January 1996 and January 2006. For each case of pancreatic cancer, data was collected from the initial breast cancer pathology report, this included : Cancer type, Grade, Estrogen Receptor status, Progesterone Receptor, HER- 2 Receptor status , BRCA gene mutation and cancer stage on diagnosis. Clinic notes and radiology reports were also reviewed to determine the presence of risk factors for pancreatic cancer, the interval of time between the two diagnosis and the stage of breast cancer at the time of diagnosis of pancreatic cancer. Results: A total of 2,669 breast cancer cases were reviewed and 5 cases of pancreatic cancers were found among patients with a previous diagnosis of breast cancer. In all these cases the breast cancer tumor was positive for Estrogen and Progesteron receptor and negative for Her2 overexpression. The incidence of pancreatic cancer in this subgroup of patients (Breast cancer, ER+,PR+, HER2-) was 1% much higher than the incidence in the general female population. Conclusions: In our experience patients with breast cancer might have a higher risk of developping pancreatic cancer. This is especially true for patients whose tumors over-express the estrogen and progesterone receptors and which do not over-express the Her2 receptor. Further studies are needed to evaluate the overall incidence of pancreatic cancer in this population and to determine the role of anti-hotmonal therapy in the prevention of these cancers. No significant financial relationships to disclose.