tbuckley/cabot-search huggingface dataset:
Performance of Ultrasound in the Diagnosis of Gout in a Multicenter Study: Comparison With Monosodium Urate Monohydrate Crystal Analysis as the Gold Standard
Authors: Alexis Ogdie, William J. Taylor, Tuhina Neogi, Jaap Fransen, Tim L. Jansen, H. Ralph Schumacher, Worawit Louthrenoo, Janitzia Vazquez‐Mellado, Maxim Eliseev, Geraldine McCarthy, Lisa K. Stamp, Fernando Perez‐Ruiz, Francisca Sivera, Hang‐Korng Ea, Martijn Gerritsen, Giovanni Cagnotto, Lorenzo Cavagna, Chingtsai Lin, Yin‐Yi Chou, Anne‐Kathrin Tausche, Manuella Lima Gomes Ochtrop, Matthijs Janssen, Jiunn‐Horng Chen, Ole Slot, Juris Lazovskis, Douglas White, Marco A. Cimmino, Till Uhlig, Nicola Dalbeth
Journal: Arthritis & Rheumatology (2016)

Objective To examine the performance of ultrasound (US) for the diagnosis of gout using the presence of monosodium urate monohydrate (MSU) crystals as the gold standard. Methods We analyzed data from the Study for Updated Gout Classification Criteria (SUGAR), a large, multicenter observational cross‐sectional study of consecutive subjects with at least 1 swollen joint who conceivably may have gout. All subjects underwent arthrocentesis; cases were subjects with confirmed MSU crystals. Rheumatologists or radiologists who were blinded with regard to the results of the MSU crystal analysis performed US on 1 or more clinically affected joints. US findings of interest were double contour sign, tophus, and snowstorm appearance. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated. Multivariable logistic regression models were used to examine factors associated with positive US results among subjects with gout. Results US was performed in 824 subjects (416 cases and 408 controls). The sensitivity, specificity, PPV, and NPV for the presence of any 1 of the features were 76.9%, 84.3%, 83.3%, and 78.2%, respectively. Sensitivity was higher among subjects with a disease duration of ≥2 years and among subjects with subcutaneous nodules on examination (suspected tophus). Associations with a positive US finding included suspected clinical tophus (odds ratio [OR] 4.77 [95% confidence interval (95% CI) 2.23–10.21]), any abnormality on plain radiography (OR 4.68 [95% CI 2.68–8.17]), and serum urate level (OR 1.31 [95% CI 1.06–1.62]). Conclusion US features of MSU crystal deposition had high specificity and high PPV but more limited sensitivity for early gout. The specificity remained high in subjects with early disease and without clinical signs of tophi.
Special Report: The American Academy of Ophthalmology Task Force for Developing Novel End Points for Premium Intraocular Lenses Introduction
Authors: Flora Lum, Jack T. Holladay, Adrian Glasser, Scott MacRae, Samuel Masket, Walter Stark, Eva Rorer, Michelle E. Tarver, Don Calogero, Gene Hilmantel, Tieuvi Nguyen, Malvina Eydelman
Journal: Ophthalmology (2016)
TCT-795 Technical success rates of endovascular treatment of femoropopliteal chronic total occlusions
Authors: Thomas M. Das, Kyle Planchard, Denizen Kocak, Atif Mohammad, Ehrin J. Armstrong, Nicolas W. Shammas, Osvaldo Gigliotti, Mazen Abu-Fadel, Anand Prasad, Andrew Klein, Emmanouil Brilakis, Subhash Banerjee
Journal: Journal of the American College of Cardiology (2015)
TCT-191 Mechanical Circulatory Support Devices and Transcatheter Aortic Valve Replacement: A Multicenter experience
Authors: Vikas Singh, Samir Patel, Nileshkumar J. Patel, Chirag Savani, Nilay Patel, Shilpkumar Arora, Sidakpal S. Panaich, Michael Cleman, Abeel A. Mangi, John K. Forrest, Apurva Badheka
Journal: Journal of the American College of Cardiology (2015)
Outcome of second-line chemotherapy with a combination of docetaxel and carboplatin (DC) in docetaxel-resistant (DR) hormone refractory prostate cancer (HRPC) patients
Authors: V. Gruenwald, P. Ivanyi, T. Winkler, M. Morgan, M. Fenner, A. Ganser, C. Reuter
Journal: Journal of Clinical Oncology (2008)

16090 Background: Docetaxel is the standard chemotherapy for HRPC. However, a standard protocol has not yet been defined for patients with DR disease. Initial reports support the use of carboplatin (C) in combination with docetaxel (D) in these patients (pts). Methods: Metastatic HRPC pts that were resistant to treatment with D were included in our retrospective analysis. Between February 2005 and December 2007, 17 pts received treatment with C AUC 5 q3wks in combination with D 75 mg/m2 q3wks or D 35 mg/m2 d1, d8, d15 q4wks. 3 pts additionally received estramustine 140 mg on 3 consecutive days in parallel to weekly applications of D. All pts were assessed for PSA response and clinical outcome. Results: Seventeen pts were identified at our institution for analysis. The median follow-up was 13 months (range: 0–31) with a median number of 4 cycles administered (range: 1–16). PSA reduction >50% was achieved in 9 pts (53%) and PSA stabilization in 5 pts (29%). 4 pts (24%) progressed without PSA response. The median duration of PSA response was 19 wks. Pts with PSA normalization or >90% reduction tended to achieve a longer PSA response (median 79 wks, range: 18–80) compared to pts with PSA stabilization or reduction by 50–90% (20 wks, range: 4–57). The most common grade 3/4 toxicities were neutropenia in 29% and thrombocytopenia in 11% of pts. Conclusions: This retrospective analysis supports the usefulness of second-line chemotherapy in HRPC. DC shows promising activity in DR pts with clinically meaningful responses. Patient Characteristics ECOG 0, No. of patients (%) 13 (76%) ECOG 1, No. of patients (%) 3 (18%) ECOG 2, No. of patients (%) 1 (6%) Liver metastases, No. of patients (%) 4 (24%) Visceral or lymphatic metastases, No. of patients (%) 6 (35%) Pain, No. of patients (%) 12 (71%) ≥2 metastatic sites, No. of patients (%) 7 (41%) Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration sanofi-aventis
TCT-447 Real World Generalizability Of Patients Enrolled In Clinical Trials Versus Those Not Enrolled
Authors: Omar A. Meelu, Samantha Sartori, Kleanthis Theodoropoulos, Swathi Roy, Roja Thapi, Usman Baber, George Dangas, Pedro R. Moreno, Prakash Krishnan, Annapoorna Kini, Samin K. Sharma, Roxana Mehran
Journal: Journal of the American College of Cardiology (2015)
GW27-e0476 A nomogram to predict contrast induced nephropathy in patients undergoing percutaneous coronary intervention: is the “anti-aging” agent klotho a candidate predictor?
Authors: Xiaodong Zhuang, Xun Hu, Zhimin Du, Yue Guo, Feifei Li, Xinxue Liao
Journal: Journal of the American College of Cardiology (2016)
Allogeneic Stem Cell Transplantation for Therapy-Related Myelodysplastic Syndrome (t-MDS) and Acute Myeloid Leukemia. A Report from the MDS Subcommittee of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT).
Authors: Nicolaus Kroeger, Ronald Brand, Anja van Biezen, Dietger Niederwieser, Theo de Witte
Journal: Blood (2007)
Violence Perpetration Among Patients Hospitalized for Unintentional and Assault-Related Firearm Injury
Authors: Ali Rowhani-Rahbar, Mary D. Fan, Joseph A. Simonetti, Vivian H. Lyons, Jin Wang, Douglas Zatzick, Frederick P. Rivara
Journal: Annals of Internal Medicine (2016)

Hospital-based violence intervention programs typically focus on patients whose firearm injury occurred through interpersonal violence (assault). Knowledge of violence perpetration by victims of unintentional (accidental) firearm injury is limited.To examine violence perpetration before and after a patient becomes hospitalized for firearm injury according to injury intent (intentional [assault] or unintentional [accidental]).A case-control study and a retrospective cohort study.Hospitals in Washington.Persons aged 15 years or older hospitalized for a firearm injury, other injuries, or a noninjury reason from 2006 to 2007.In the case-control study, the odds of violence-related arrest from 2001 through hospitalization by injury intent among 3 groups were compared. In the cohort study, the rates of violence-related arrest from hospitalization through 2011 by injury intent among 3 groups were compared.Patients with unintentional firearm injuries (n = 180) were more likely than those with other unintentional injuries (n = 62 795; odds ratio [OR], 2.01 [95% CI, 1.31 to 3.09]) and no injuries (n = 172 830; OR, 3.43 [CI, 2.22 to 5.32]) to have been arrested for a violent crime before hospitalization. Prior violence-related arrest did not differ between patients with assault-related firearm injuries (n = 339) and those with other assault-related injuries (n = 2342; OR, 1.10 [CI, 0.84 to 1.46]). During follow-up, the cumulative incidence of violence-related arrest for patients with unintentional and assault-related firearm injuries was 10% and 15% (subhazard ratio, 1.88 [CI, 1.11 to 3.17] and 1.61 [CI, 1.08 to 2.44]), respectively, compared with 1% for those without injuries.Exclusion of self-inflicted injuries, misclassification of intent, and ascertainment bias.Some firearm injuries classified as accidental may indicate involvement in the cycle of violence and present an opportunity for intervention.City of Seattle and the University of Washington Royalty Research Fund.
The SET Oncogene, a Potent PP2A Inhibitor, Is Elevated in CLL and Antagonism of SET Induces Apoptosis.
Authors: Dale J. Christensen, Karen M. Bond, Alicia D. Volkheimer, Jessica Oddo, Youwei Chen, Jon P. Gockerman, Joseph O. Moore, Louis F. Diehl, Carlos M. de Castro, Michael P. Vitek, J. Brice Weinberg
Journal: Blood (2009)
Integrative Systemic and Local Metabolomics with Impact on Survival in High-Grade Serous Ovarian Cancer
Authors: Anna Bachmayr-Heyda, Stefanie Aust, Katharina Auer, Samuel M. Meier, Klaus G. Schmetterer, Sabine Dekan, Christopher Gerner, Dietmar Pils
Journal: Clinical Cancer Research (2016)

Purpose: Cancer metabolism is characterized by alterations including aerobic glycolysis, oxidative phosphorylation, and need of fuels and building blocks.Experimental Design: Targeted metabolomics of preoperative and follow-up sera, ascites, and tumor tissues, RNA sequencing of isolated tumor cells, local and systemic chemokine, and local immune cell infiltration data from up to 65 high-grade serous ovarian cancer patients and 62 healthy controls were correlated to overall survival and integrated in a Systems Medicine manner.Results: Forty-three mainly (poly)unsaturated glycerophospholipids and four essential amino acids (citrulline) were significantly reduced in patients with short compared with long survival and healthy controls. The glycerophospholipid fingerprint is identical to the fingerprint from isolated (very) low-density lipoproteins (vLDL), indicating that the source of glycerophospholipids consumed by tumors is (v)LDL. A glycerophospholipid-score (HR, 0.46; P = 0.007) and a 100-gene signature (HR, 0.65; P = 0.004) confirmed the independent impact on survival in training (n = 65) and validation (n = 165) cohorts. High concentrations of LDLs and glycerophospholipids were independently predictors for favorable survival. Patients with low glycerophospholipids presented with more systemic inflammation (C-reactive protein and fibrinogen negatively and albumin positively correlated) but less adaptive immune cell tumor infiltration (lower tumor and immune cell PD-L1 expression), less oxygenic respiration and increased triglyceride biosynthesis in tumor cells, and lower histone expressions, correlating with higher numbers of expressed genes and more transcriptional noise, a putative neo-pluripotent tumor cell phenotype.Conclusions: Low serum phospholipids and essential amino acids are correlated with worse outcome in ovarian cancer, accompanied by a specific tumor cell phenotype. Clin Cancer Res; 23(8); 2081-92. ©2016 AACR.
Duration of Prehospital Cardiopulmonary Resuscitation and Favorable Neurological Outcomes for Pediatric Out-of-Hospital Cardiac Arrests
Authors: Yoshikazu Goto, Akira Funada, Yumiko Goto
Journal: Circulation (2016)

The appropriate duration of cardiopulmonary resuscitation (CPR) for pediatric out-of-hospital cardiac arrests (OHCAs) remains unclear and may differ based on initial rhythm. We aimed to determine the relationship between the duration of prehospital CPR by emergency medical services (EMS) personnel and post-OHCA outcomes.We analyzed the records of 12 877 pediatric patients who experienced OHCAs (<18 years of age). Data were recorded in a nationwide Japanese database between 2005 and 2012. Study end points were 30-day survival and 30-day survival with favorable neurological outcomes (Cerebral Performance Category [CPC] scale 1-2). Prehospital EMS-initiated CPR duration was defined as the time from CPR initiation by EMS personnel to prehospital return of spontaneous circulation (ROSC) or to hospital arrival when prehospital ROSC was not achieved during prehospital CPR efforts.The rates of 30-day survival and 30-day CPC 1 to 2 were 9.1% (n=1167) and 2.5% (n=325), respectively. Prehospital EMS-initiated CPR duration was significantly and inversely associated with 30-day outcomes (adjusted odds ratio for 1-minute increments: 0.94, 95% confidence interval: 0.93-0.95 for survival; adjusted odds ratio: 0.90, 95% confidence interval: 0.88-0.92 for CPC 1-2). The duration of prehospital EMS-initiated CPR, beyond which the chance for favorable outcomes diminished to <1%, was 42 minutes for each key outcome, 30-day survival, and 30-day survival with CPC 1 to 2. When categorized by initial rhythm, the prehospital EMS-initiated CPR durations beyond which the chance for 30-day survival with CPC 1 to 2 diminished to <1% were 39 minutes for shockable rhythms, 42 minutes for pulseless electric activity, and 46 minutes for asystole, respectively. In patients with bystander-initiated CPR, the prehospital CPR duration, beyond which the chance for favorable outcome diminished to <1%, was 46 minutes from call receipt.Prehospital EMS-initiated CPR duration for pediatric OHCAs was independently and inversely associated with 30-day favorable outcomes. The duration of prehospital EMS-initiated CPR, beyond which the chance for 30-day favorable outcomes diminished to <1%, was 42 minutes. However, the CPR duration to achieve this proportion of outcomes differed based on initial rhythm. Further research is required to elucidate appropriate CPR duration for pediatric OHCAs, including in-hospital CPR time.URL: https://clinicaltrials.gov. Unique identifier: NCT02432196.
Impact of RAS Mutations In Myelodysplastic Syndrome (MDS)
Authors: Aref Al-Kali, Rajyalakshmi Luthra, Carlos E. Bueso-Ramos, Sherry Pierce, Tapan Kadia, Gautam Borthakur, Zeev Estrov, Elias Jabbour, Stefan Faderl, Farhad Ravandi, Jorge Cortes, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2010)
Postoperative LV5FU2 combination chemotherapy in patients with curative resected advanced gastric cancer
Authors: H. Lee, K. Lee, E. Park, I. Hwang, J. Jang, S. Lee
Journal: Journal of Clinical Oncology (2009)

e15660 Background: To illuminate the effect and toxicity of fortnightly low-dose leucovorin(LV) and fluorouracil(5FU) bolus plus continuous infusion(LV5FU2) postoperative chemotherapy(adjuvant) in patients with curative resected, advanced gastric cancer. Methods: Total 40 patients were enrolled in this study. All patients received LV 20mg/m 2 (bolus), 5FU 400mg/m 2 (bolus), 5FU 600mg/m 2 (24-hour continuous infusion) on day 1, 2, 15, and 16, every 4 weeks(LV5FU2), total 6 cycles. Results: Postoperative chemotherapy was initiated median 19 days after surgery. Total of 238 cycles were administered and median follow-up was 602 days. The median disease-free survival time was 728 days (95% CI, 411∼1045) and 2-year overall survival was 77%. Relapses were reported in 18 (45%) of the patients : Two of 9 patients relapsed in stage IIIA (22.2%), seven of 12 patients relapsed in stage IIIB (58.3%) and nine of 17 patients relapsed in stage IV (52.9%). They were all distant relapsed. Eight patients died. 7 patients died as a result of cancer progression and 1 patient suicided while receiving palliative chemotheraphy for cancer relapse. The grade 3∼4 toxicity of neutropenia 8.4% and anemia 0.4%, neutropenic fever 0.4% were observed. Conclusions: Postoperative LV5FU2 adjuvant chemotherapy is effective and tolerable for the patients with curative resected, advanced gastric cancer. No significant financial relationships to disclose.
Quality of Life (QoL) Impairment and International Prognostic Index (IPI) in New Aggressive Non-Hodgkin’s Lymphoma (ANHL) Patients.
Authors: Andrei A. Novik, Tatiana I. Ionova, Anton V. Kishtovich, Alexander A. Myasnikov, Tatiana V. Chagorova, Mikhail V. Kopp, Nina E. Osipova, Julia K. Lebedeva, Natalia N. Malakchova, Anastasia V. Pankova, Denis A. Fedorenko, Gary I. Gorodokin
Journal: Blood (2005)
Assessing flow limitation in patients with stable coronary artery disease
Authors: Jonathan N Townend, Peter F Ludman, Sagar N Doshi, Hamid Khan, Patrick A Calvert
Journal: BMJ (2016)

Has simple coronary angiography had its day?

Appropriate use of revascularisation in stable angina depends on cardiologists being able to discriminate flow limiting coronary atherosclerotic lesions from those that are merely bystanders. Invasive angiography has been used for this purpose for many years but is problematic because it is an anatomical assessment of a physiological property. Assessment of lesions by eye or quantitative measurement is known to be inaccurate.1 But studies over the past decade have shown that flow limitation can be accurately assessed by using a pressure wire to measure fractional flow reserve (FFR)—the ratio of distal to proximal pressures during maximal hyperaemia induced by adenosine infusion.

When validated against non-invasive stress testing, a threshold FFR of 0.75 was found to discriminate ischaemic from non-ischaemic flow limitation , although to maximise sensitivity a value of 0.8 is usually used in practice.2 In the Defer study, published in 2007, risk of death or myocardial infarction was less than 1% a year (over five years) among …
Concomitant, bismuth quadruple, and 14-day triple therapy in the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial
Authors: Jyh-Ming Liou, Yu-Jen Fang, Chieh-Chang Chen, Ming-Jong Bair, Chi-Yang Chang, Yi-Chia Lee, Mei-Jyh Chen, Chien-Chuan Chen, Cheng-Hao Tseng, Yao-Chun Hsu, Ji-Yuh Lee, Tsung-Hua Yang, Jiing-Chyuan Luo, Chun-Chao Chang, Chi-Yi Chen, Po-Yueh Chen, Chia-Tung Shun, Wen-Feng Hsu, Wen-Hao Hu, Yen-Nien Chen, Bor-Shyang Sheu, Jaw-Town Lin, Jeng-Yih Wu, Emad M El-Omar, Ming-Shiang Wu
Journal: The Lancet (2016)
Invasive Pulmonary Aspergillosis Is Not a Contraindication to Reduced-Intensity Conditioned Allogeneic Haematopoietic Stem Cell Transplantation (RIC allo-HSCT).
Authors: Aloysius Y.L. Ho, Sujal R. Desai, Ian D.P. Stanton, Susan J. Copley, Athol U. Wells, Antonio Pagliuca, Stephen Devereux, Ghulam J. Mufti
Journal: Blood (2004)
Bendamustine Induces Higher Remission Rates, Prolongs Progression Free Survival as Well as Time to Next Treatment, and Improves Overall Survival for Patients In Complete Remission without Compromising Quality of Life When Compared to Chlorambucil In First Line Treatment of Chronic Lymphocytic Leukemia
Authors: Wolfgang Ulrich Knauf, Toshko Lissitchkov, Ali Aldaoud, Anna Marina Liberati, Javier Loscertales, Raoul Herbrecht, Gunnar Juliusson, Gerhard Postner, Liana Gercheva, Stefan Goranov, Martin Becker, Hans-Joerg Fricke, Françoise Huguet, Ilaria Del Guidice, Peter Klein, Karlheinz Merkle, Marco Montillo
Journal: Blood (2010)
Molecular Pathways: Maintaining MAPK Inhibitor Sensitivity by Targeting Nonmutational Tolerance
Authors: Michael P. Smith, Claudia Wellbrock
Journal: Clinical Cancer Research (2016)

Targeting hyperactive MAPK signaling has proven to be an effective treatment for a variety of different cancers. Responses to the BRAF inhibitors vemurafenib and dabrafenib and the MEK inhibitors trametinib and cobimetinib are, however, transient, and complete remission is rarely observed; rather, outgrowth of resistant clones within progressed tumors appears inevitable. These resistant tumors display great heterogeneity, which poses a major challenge to any salvage therapy. Recent focus has, therefore, been on the early dynamics of inhibitor response during tumor regression. During this time, cells can persist in an adapted tolerant state, which results in a phase of nonmutational drug tolerance. In this article, we discuss how inhibition of the MAPK pathway leads to an adaptive rewiring that evolves from the relief of immediate negative feedback loops to short-term gene expression changes and adaptation of intracellular signaling. Tolerance can also be mediated by external signaling from the tumor microenvironment, which itself adapts upon treatment and the selection for cells with an innate drug-tolerant phenotype. In preclinical models, combination treatment with receptor tyrosine kinase (RTK) inhibitors (lapatinib and dasatinib), histone deacetylase (HDAC) inhibitors (vorinostat and entinostat), or drugs targeting cancer-specific mechanisms (nelfinavir in melanoma) can overcome this early tolerance. A better understanding of how nonmutational tolerance is created and supported may hold the key to better combinational strategies that maintain drug sensitivity. Clin Cancer Res; 22(24); 5966-70. ©2016 AACR.
GW26-e2936 The ACE2-Ang(1-7)-Mas Axis may be the angel and play the protective role in the occurrence and maintaining of Atrial Fibrillation in The Patients with Rheumatic Valvular Heart Disease
Authors: Yongrong Jiang, Junqiang Pan, Xin Zhou, Chaofeng Sun
Journal: Journal of the American College of Cardiology (2015)
Prognostic significance of PI3K mRNA expression in patients with operable high-risk breast cancer
Authors: G. Papaxoinis, D. Pectasides, R. M. Wirtz, V. Kotoula, C. Papadimitriou, H. Gogas, G. Aravantinos, D. Skarlos, K. T. Kalogeras, G. Fountzilas
Journal: Journal of Clinical Oncology (2009)

577 Background: The aim of the study was to examine the prognostic and predictive significance of PI3K, AKT-1, mTOR, and PTEN mRNA expression and PIK3CA mutations in patients with operable high-risk breast cancer. Methods: Formalin-fixed paraffin-embedded tumor tissue blocks were available from 279 out of 595 operable high-risk breast cancer patients enrolled in a phase III clinical trial of E-T-CMF vs E-CMF. Updated clinical data were retrospectively used in the present translational research study. RNA was isolated followed by kinetic one-step quantitative RT-PCR for assessment of the expression of PI3K, AKT-1, mTOR, and PTEN. Mutations (E542K, E545K and H1047R) in the helical (exon 9) and the kinase (exon 20) domains of the PIK3CA gene encoding the catalytic p110 subunit of PI3K were investigated with custom Taqman SNP genotyping assays in 223 tumor DNA samples from the patient population enrolled in this study. Results: The two groups were well balanced concerning their basic characteristics except for grade (p = 0.015). The vast majority of hormone receptor positive patients (92%) received tamoxifen for 5 years, with LHRH analogs for premenopausal patients. The distribution of AKT-1 values was bimodal and therefore the 25th percentile was a natural cut-off. The median was used as a cut-off for all other genes. Mutations of the PIK3CA gene were detected in 51 patients (23%) (E542K in 8, E545K in 17 and H1047R in 26 patients). After a median follow-up time of 97 months, 93 patients (33%) had relapsed and 65 (23%) had died. High PI3K mRNA expression was associated with significantly shorter DFS (p = 0.044), irrespectively of the treatment arm. Multivariate analysis showed that high PI3K mRNA expression was an adverse prognostic factor for OS (HR = 2.14, 95% CI = 1.16–3.94, p = 0.015) and DFS (HR = 1.71, 95% CI = 1.09–2.68, p = 0.02), while PIK3CA mutations negatively affected OS (HR = 2.05, 95% CI = 1.07–3.95, p = 0.031). None of the other genes assessed was found to be of prognostic significance. Conclusions: High PI3K mRNA expression and PIK3CA mutations appear to be of adverse prognostic significance in patients with high-risk operable breast cancer. No significant financial relationships to disclose.