tbuckley/cabot-search huggingface dataset:
THU0519 Xanthine Oxidase Gene Variants and Their Association with Blood Pressure and Incident Hypertension: A Population Study
Authors: L.E. Scheepers, F. Wei, K. Stolarz-Skrzypek, S. Malyutina, V. Tikhonoff, L. Thijs, E. Salvi, C. Barlassina, J. Filipovský, E. Casiglia, Y.P. Nikitin, K. Kawecka-Jaszcz, P. Manunta, D. Cusi, A. Boonen, J.A. Staessen, I.C. Arts
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Uric acid has been associated with blood pressure and hypertension. During the final stage of purine metabolism xanthine oxidoreductase (XOR) produces uric acid, while at the same time reactive oxygen species are formed. We hypothesized that uric acid production, as assessed indirectly from <i>XOR</i> variants, is associated with hypertension (figure 1). <h3>Objectives</h3> The aim of the present study is to investigate the association of variants in the <i>XOR</i> gene with blood pressure and the development of hypertension. <h3>Methods</h3> Analyses were conducted in the prospective Flemish FLEMENGHO and European EPOGH study. Among 2769 participants (48.3% men; mean age 40.7 years) we genotyped 25 <i>XOR</i> SNPs and measured blood pressure at baseline and follow-up (median 8.8 years). The relation between variants of the <i>XOR</i> gene with changes in pulse pressure and mean arterial pressure over time; and incidence of hypertension, were analysed using multivariable mixed models and cox-regression, respectively. <h3>Results</h3> Compared with major allele homozygotes, pulse pressure increased approximately 2 mm Hg more in minor allele carriers of rs11904439 (<i>P=</i>value 0.01), whereas mean arterial pressure and diastolic blood pressure increased approximately 1 mm Hg less in minor allele carriers of rs2043013 (<i>P</i>=0.01). In 2050 participants normotensive at baseline, hazard ratios contrasting risk of hypertension in minor allele carriers <i>vs.</i> major allele homozygotes was 1.31 (95% confidence interval [CI] 1.03–1.68) for rs11904439 and 1.69 (95% CI 1.11–2.57) for rs148756340. With the false discovery rate set at 0.25, the aforementioned associations retained significance. The changes in systolic blood pressure from baseline to follow-up and the serum levels of uric acid at baseline (n=1949) were not associated with <i>XOR</i>. <h3>Conclusions</h3> In conclusion, pending confirmation in appropriately powered cohort studies, our findings suggest that variation in uric acid production, as captured by genetic variation in <i>XOR</i>, might be a predictor of changes in pulse pressure, mean arterial pressure and in the risk of hypertension. <h3>Acknowledgement</h3> The authors gratefully acknowledge the clerical assistance of Mrs Renilde Wolfs. <h3>Disclosure of Interest</h3> None declared
OC-061 Algorithm and Case-Based Educational Intervention Improves Nursing Staff Confidence in Management of Patients On Direct Oral Anticoagulants (DOACS) in Endoscopy
Authors: J Catlow, K Prokas
Journal: Gut (2016)

<h3>Introduction</h3> The increased use of DOACs in medicine, is a challenge for endoscopy unit staff, faced with new anticoagulants, new national guidance based on low quality evidence, and new renal function tests to interpret. Guidance by Veitch (2016) and a systematic review by Woodhouse (2013) suggest practical management algorithms for DOACs in endoscopy, which we aimed to summarise into an interactive case based teaching session, to improve nursing confidence. <h3>Methods</h3> We developed an hour long teaching course for all endoscopy nurses in our District General Hospital. Small groups discussed previous experience of DOACs, a brief interactive seminar introduced a locally tailored treatment algorithm based on Veitch (2016) and Woodhouse (2013) (Figure 1). Participants were formatively assessed on identifying DOACs, interpreting renal function and applying a management algorithm to common clinical cases. Subjective confidence on each learning objective was assessed pre- and post-educational intervention, using Likert scales graded 1 (strongly disagree) to 5 (strongly agree), and analysed using a paired T-test. Free text responses were collected and phenomenological analysed. <h3>Results</h3> 18 endoscopy nursing staff undertook training in two sessions. Mean subjective confidence scores improved significantly, in all learning objectives (Table 1). Eleven free text comments praised the use of case studies and the algorithm, as “<i>real life scenarios help to consolidate my learning</i>”. Others commented this teaching should be “<i>cascaded to referrers</i>”. <h3>Conclusion</h3> Case based learning activities, using an algorithm approach, amongst nursing staff, significantly increased confidence in managing DOACs in endoscopy. This format is readily reproducible in other endoscopy units, and a useful framework to further educate referrers to endoscopy, and patients taking DOACs. <h3>References</h3> 1 Woodhouse C, <i>et al</i>. <i>Frontline Gastroenterology</i> 2013;<b>4</b>:213–218. 2 Veitch AM, <i>et al</i>. <i>Gut</i> 2016;<b>65</b>:374–389. <h3>Disclosure of Interest</h3> None Declared
Role of Allogeneic Hematopoietic Stem Cell Transplantation in t(4;11) Positive Acute Lymphoblastic Leukemia (ALL): A Retrospective Multicenter Study of the Italian Association of Pediatric Hematology and Oncology (AIEOP)
Authors: Luca Lo Nigro, Marco Zecca, Franca Fagioli, Edoardo Lanino, Chiara Messina, Marco Rabusin, Domenico Ripaldi, Attilio Rovelli, Arcangelo Prete, Franco Locatelli
Journal: Blood (2014)
Clinical characteristics and outcome of respiratory syncytial virus infection among adults hospitalized with influenza-like illness in France
Authors: P. Loubet, N. Lenzi, M. Valette, V. Foulongne, A. Krivine, N. Houhou, G. Lagathu, S. Rogez, S. Alain, X. Duval, F. Galtier, D. Postil, P. Tattevin, P. Vanhems, F. Carrat, B. Lina, O. Launay, K. Seddik, Z. Lesieur, I. Bonmarin, P. Loulergue, H. Bodilis, M. Servera-Miyalou, I. Sadler, S. Momcilovic, R. Kanaan, N. Coolent, K. Tan Boun, P. Blanche, J. Charpentier, F. Daviaud, N. Mongardon, A. Bretagnol, Y.E. Claessens, F. Rozenberg, Y. Yazdanpanah, C. Burdet, S. Harent, M. Lachatre, C. Rioux, A. Bleibtreu, E. Casalino, C. Choquet, A. Leleu, K. Belghalem, L. Colosi, M. Ranaivoson, V. Verry, L. Pereira, E. Dupeyrat, J. Bernard, N. Emeyrat, P. Chavance, A. Debit, M. Aubier, P. Pradere, A. Justet, H. Mal, O. Brugiere, T. Papo, T. Goulenok, M. Boisseau, R. Jouenne, J.F. Alexandra, A. Raynaud-Simon, M. Lilamand, A. Cloppet-Fontaine, K. Becheur, A.L. Pelletier, N. Fidouh, P. Ralaimazava, F. Beaumale, Y. Costa, E. Munier, F. Betend, S. Amour, S. Loeffert, K. Francourt, C. Merle, F. Letois, P. Géraud, V. Driss, S. Noslier, M. Ray, M. Sebbane, A. Konaté, A. Bourdin, K. Klouche, M.S. Léglise, E. Couve-Deacon, D. Fruit, C. Fenerol, C. Vallejo, S. Jouneau, F. Lainé, E. Thébault, P. Fillatre, C. Le Pape, L. Beuzit, F. Chau, F. Carrat, F. Chau, I. Goderel
Journal: Clinical Microbiology and Infection (2016)
miRNA in Serum and Bone Marrow Plasma Cells From Multiple Myeloma Patients.
Authors: Andrew Stiff, Alberto Rocci, Craig C. Hofmeister, Paola Omedè, Susan Geyer, Sara Bringhen, Luciano Cascione, Anissa Bingman, Manuela Gambella, Federica Cavallo, Luciana De Luca, Jingwen Guan, Alessandra Larocca, Jacqueline Corry, Francesca Gay, Yvonne A Efebera, Uccello G, Don M. Benson, Tiffany Talabere, Kevin Murnan, Magarotto Valeria, Mario Boccadoro, Carlo M. Croce, Antonio Palumbo, Flavia Pichiorri
Journal: Blood (2012)
SAT0591 Consensus Statement for The Evaluation and Management of Patients with Autoimmune and Inflammatory Diseases during Fertility, Pregnancy, Post-Partum and Breastfeeding
Authors: J.A. Martínez-Lόpez, M.L. García Vivar, R. Caliz, E. Loza, M. Freire, M. Galindo, M.V. Hernández, F.J. Lόpez Longo, V. Martínez Taboada, J.M. Pego Reigosa, E. Rubio, E. Trujillo, P. Vela-Casasempere
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Nowadays there is a great variability in evaluation and management of patients with autoimmune and inflammatory diseases during fertility, pregnancy, post-partum and breastfeeding, in part due to lack of knowledge. <h3>Objectives</h3> To develop recommendations on the evaluation and management of patients with autoimmune and inflammatory diseases during fertility, pregnancy, post-partum and breastfeeding based on the best evidence and experience. <h3>Methods</h3> Recommendations were generated following nominal group methodology and Delphi technique. A panel of experts was established (12 rheumatologists). A systematic literature review and a narrative review (websites, clinical guidelines and other relevant documentation) were performed and presented to the panel in the 1st panel meeting to be discussed and to help define recommendations. A first draft of recommendations was generated and circulated for comments and wording refinements. A national survey analyzing different aspects of this topic was undertaken separately. Then, a Delphi process (2 rounds) was carried out. Recommendations were voted from 1 (total disagreement) to 10 (total agreement). We defined agreement if at least 70% voted ≥7. The level of evidence and grade or recommendation was assessed using the Oxford Centre for Evidence-based Medicine Levels of Evidence. <h3>Results</h3> A total of 14 recommendations (see figure) were generated on the pre-conception period (oral and hormonal anticonception, reproductive techniques), pregnancy (planning, treatment and follow-up), and breastfeeding (treatment and follow-up). High risk situations were included as lupus or antiphospholipid syndrome. A consensus &gt;90% was reached in all but one recommendation. <h3>Conclusions</h3> These recommendations are intended to provide rheumatologists, patients, families and other stakeholders a consensus on the evaluation and management of patients with autoimmune and inflammatory diseases during fertility, pregnancy, post-partum and breastfeeding. <h3>Disclosure of Interest</h3> None declared
SAT0008 Il-17a Gene Implication in spanish Patients with Rheumatoid Arthritis
Authors: F. Genre, R. Lόpez-Mejías, S. Remuzgo-Martínez, M. Robustillo-Villarino, S. Castañeda, C. González-Juanatey, J. Llorca, A. Corrales, B. Ubilla, V. Mijares, J.A. Miranda-Filloy, T. Pina, C. Gόmez-Vaquero, L. Rodríguez-Rodríguez, B. Fernández-Gutiérrez, A. Balsa, D. Pascual-Salcedo, F.J. Lόpez-Longo, P. Carreira, R. Blanco, I. González-Άlvaro, J.J. Alegre-Sancho, C. Magro, E. Raya, J. Martín, M.Ά. González-Gay
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune pathology associated with increased risk of cardiovascular (CV) disease and subclinical atherosclerosis<sup>1</sup>. Consequently, both inflammatory diseases share common molecules involved in its pathogenesis. In this sense, interleukin 17A (IL-17A) is a pro-inflammatory cytokine involved in the regulation of immune responses and chronic inflammation<sup>2</sup>. <h3>Objectives</h3> To evaluate the potential association between different IL-17A polymorphisms and CV events, as well as subclinical atherosclerosis, in a large cohort of Spanish RA patients. <h3>Methods</h3> Five IL-17A polymorphisms (rs4711998, rs8193036, rs3819024, rs2275913 and rs7747909) were genotyped by TaqMan assays in a 7900 HT Real-Time polymerase chain reaction system in 1,974 Spanish patients diagnosed with RA (fulfilling the 2010 American College of Rheumatology classification criteria for RA<sup>3</sup>), recruited from different Spanish hospitals. 318 patients (16.1%) had experienced CV events, and 822 had undergone carotid ultrasonography studies to assess subclinical atherosclerosis (presence/absence of plaques and carotid intima media thickness [cIMT]). The relationship between IL-17A alleles, genotypes and haplotypes and CV events, presence/absence of plaques and cIMT values was assessed. Results were adjusted for sex, age at diagnosis and traditional CV risk factors. <h3>Results</h3> No statistically significant differences were observed when allelic/genotypic frequencies of each IL-17A polymorphism were assessed regarding presence/absence of CV events, plaques or cIMT values. This was also the case when the five polymorphisms were combined to form haplotypes. <h3>Conclusions</h3> Our results do not confirm an association between the five IL-17A polymorphisms studied and the development of CV events or subclinical atherosclerosis in our cohort of Spanish RA patients. <h3>References</h3> Avina-Zubieta JA et al. Ann Rheum Dis. 2012;71:1524–9. Shabgah AG et al. Postepy Dermatol Alergol. 2014;31(4):256–61. D. Aletaha T et al. Arthritis Rheum. 2010;62:2569–81. <h3>Acknowledgement</h3> This study was supported by European Union FEDER funds and "Fondo de Investigaciόn Sanitaria" (PI12/00060 and PI15/00525) (Spain), and partially supported by RETICS Programs RD12/0009 (RIER) from "Instituto de Salud Carlos III" (ISCIII) (Spain). FG is a recipient of a Sara Borrell postdoctoral fellowship from the ISCIII (Spain) (CD15/00095). RL-M and BU are supported by funds from the RETICS Program (RIER) (RD12/0009/0013). <h3>Disclosure of Interest</h3> None declared
Radioimmunotherapy (RIT) with 177 Lutetium-DOTA-Rituximab (177LU-D- R): A Phase I/II - Study in 30 Patients with Relapsing Follicular, Mantle Cell and Other Indolent B-Cell Lymphomas
Authors: Andreas Lohri, Flavio Forrer, Benedetta Campana, Christoph Mamot, Ralph Winterhalder, Richard Herrmann, Helmuth R Maecke, Jan Müller-Brand
Journal: Blood (2008)
RNAi-Mediated Silencing of p190Bcr-Abl Inactivates Stat5 and Cooperates with Imatinib Mesylate and 17-Allylamino-17-Demetoxygeldanamycin in Selective Killing of p190Bcr-Abl-Expressing Leukemia Cells.
Authors: Muneyoshi Futami, Toshiyuki Hatano, Yasushi Soda, Seiichiro Kobayashi, Makoto Miyagishi, Arinobu Tojo
Journal: Blood (2007)
Abstract 5059: hHO-1 Overexpression in Transgenic Pigs is Cardioprotective After Acute Myocardial Ischemia and Reperfsuion
Authors: Rabea Hinkel, Björn Petersen, Michael Thormann, Jan Horstkotte, Alexander Wuchrer, Michael Schmoeckel, Heiner Niemann, Christian Kupatt
Journal: Circulation (2009)

The inducible isoform of heme oxygenase (HO-1) responds to stress, such as hypoxia or cytokine activation, by reducing biliverdin to bilirubin, carbon monoxide (CO) and free iron. These have anti-inflammatory, anti-apoptotic potential and reduce free radical formation. During ischemia and even more during reperfusion these mechanisms play a major role for the extent of injury. Now, we investigated the cardio protective potential of a heme oxygenase-1 overexpression in transgenic pigs after acute myocardial ischemia and reperfusion. Methods: Transgenic pigs were generated through somatic nuclear transfer of the humane heme oxygenase 1 gene. In vivo, pigs (n=4 per group) underwent percutaneous LAD occlusion for 60 min, followed by 24 hours of reperfusion. Ejection fraction was obtained before ischemia and after 24 h of reperfusion. In addition regional myocardial function and infarct size were measured at day 1. PCR was performed to assure the HO-1 over expression in the transgenic pigs. Myeloperoxidase (MPO) levels were obtained to analyze inflammatory cell invasion. Results: The PCR analysis revealed overexpression of hHO-1 mRNA levels in the transgenic pigs compared to the wildtype control group. In vivo, hHO-1 overexpressing pigs a significant better global myocardial function compared to the control group (post-ischemic ejection fraction 41±2 vs. 24±4% in control). The analysis of the regional myocardial function showed an improved function in the infarct area of the transgenic group (50±4 % vs. 28±9% of the normoxic level at rest). Infarct size was reduced in hHO-1 overexpressing pigs, compared to controls (35±4 % vs. 63±4% of the area at risk), The evaluation of the leukocyte influx in the ischemic tissue via MPO assay displayed a clear reduction in the transgenic group compared to control (444±24 vs. 2817±831 in control group). Conclusion: We could demonstrate for the first time the cardioprotective potential of heme oxgenase-1 over expression in a transgenic pig model of ischemia and reperfusion. These results indicate a high therapeutic potential of HO-1 after acute myocardial infarction or other ischemia and reperfusion events (such as organ transplantation).
Re-Expression of the AML1/ETO Target Gene LAT2/NTAL/LAB Results In Direct Interference with Myeloid Differentiation In AML1/ETO-Positive Cells
Authors: Jesus Duque-Afonso, Aitomi Essig, Leticia M Solari, Tobias Berg, Heike L. Pahl, Michael Lübbert
Journal: Blood (2010)
Beyond old dichotomies: Individual differentiation can occur <i>through</i> group commitment, not despite it
Authors: Matthew J Hornsey, Jolanda Jetten
Journal: Behavioral and Brain Sciences (2016)

Abstract The target article resuscitates an old but outdated dichotomy: a theoretical dualism between group belonging and intragroup differentiation. A convergence of evidence – including that within the social identity tradition – shows that intragroup differentiation is not incompatible with strong group identity. Indeed, when norms encourage autonomy, dissent, and individual freedom, intragroup differentiation occurs through group commitment, not despite it.
OC-054 Development and Validation of a Classification System to Identify Barrett’s Neoplasia Using Acetic Acid Chromoendoscopy: The Predict Classification: Abstract OC-054 Table 1
Authors: K Kandiah, FJQ Chedgy, G Longcroft-Wheaton, O Pech, J De Caestecker, S Green, C Gordon, A Li, H Barr, P Bhandari
Journal: Gut (2016)

<h3>Introduction</h3> Neoplasia in Barrett’s can be discrete and patchy. Acetic acid chromoendoscopy (AAC) has been demonstrated to highlight neoplastic areas allowing for earlier treatment. Previous efforts to create a classification system for AAC have not been systematic and rigorous in their methodology. We aimed to develop and validate a classification system to identify Barrett’s neoplasia using AAC. <h3>Methods</h3> Three expert AAC endoscopists (PB, GLW, OP) formed a working group to identify AAC component criteria of non-dysplastic and dysplastic Barrett’s using a modified Delphi Method. Following this, a panel of 7 AAC experienced endoscopists assessed the performance of each individual criterion by reviewing a bespoke online database of 40 images and 40 videos of non-dysplastic and dysplastic Barrett’s lesions. Finally, we assessed the diagnostic reproducibility of the validated criteria by asking 13 non-AAC experienced endoscopists to complete an assessment tool of 40 images and 20 videos. <h3>Results</h3> The component criteria identified by the expert AAC endoscopists were as follows <b>Early focal loss of acetowhitening </b> <b>Present</b>: Indicates the presence of neoplasia <b>Absent:</b> Indicates the absence of neoplasia <b>Surface pattern </b> <b>Normal (Large uniformly distributed pits)</b>: Indicates non-neoplastic Barrett’s <b>Abnormal (Compact, irregular or absent pits)</b>: Indicates neoplastic Barrett’s A total of 560 observations were undertaken to validate these criteria. The sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) are shown in Table 1: When the AAC validated criteria are applied by the 13 endoscopists, the sensitivity, specificity, NPV and PPV of detecting neoplastic Barrett’s are 98.5%, 64.0%, 97.5% and 72.5% respectively. <h3>Conclusion</h3> We have developed and established the validity of a simple classification system to identify Barrett’s neoplasia using AAC. When non-AAC experienced endoscopists apply these criteria, the sensitivity and NPV meet the recommended PIVI threshold. <h3>Disclosure of Interest</h3> None Declared
Paraoxonase 1 Activity and Pon 1 Gene Polymorphisms As a Potential Prognostic Biomarker in Sickle Cell Disease
Authors: Joelma F Menezes, Magda SO Carvalho, Larissa C Rocha, Valma Maria Lopes Nascimento, Isa Menezes Lyra, Mauricio Carvalho, Marco Aurelio Salvino, Bruno Cerqueira, Wendell Villas Boas, Marilda Souza Goncalves
Journal: Blood (2014)
Dementia Trends in the United States
Authors: Ozioma C. Okonkwo, Sanjay Asthana
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Mouse Models of Pediatric Supratentorial High-grade Glioma Reveal How Cell-of-Origin Influences Tumor Development and Phenotype
Authors: Smitha Sreedharan, Naga Prathyusha Maturi, Yuan Xie, Anders Sundström, Malin Jarvius, Sylwia Libard, Irina Alafuzoff, Holger Weishaupt, Mårten Fryknäs, Rolf Larsson, Fredrik J. Swartling, Lene Uhrbom
Journal: Cancer Research (2016)

High-grade glioma (HGG) is a group of primary malignant brain tumors with dismal prognosis. Whereas adult HGG has been studied extensively, childhood HGG, a relatively rare disease, is less well-characterized. Here, we present two novel platelet-derived growth factor (PDGF)-driven mouse models of pediatric supratentorial HGG. Tumors developed from two different cells of origin reminiscent of neural stem cells (NSC) or oligodendrocyte precursor cells (OPC). Cross-species transcriptomics showed that both models are closely related to human pediatric HGG as compared with adult HGG. Furthermore, an NSC-like cell-of-origin enhanced tumor incidence, malignancy, and the ability of mouse glioma cells (GC) to be cultured under stem cell conditions as compared with an OPC-like cell. Functional analyses of cultured GC from these tumors showed that cells of NSC-like origin were more tumorigenic, had a higher rate of self-renewal and proliferation, and were more sensitive to a panel of cancer drugs compared with GC of a more differentiated origin. These two mouse models relevant to human pediatric supratentorial HGG propose an important role of the cell-of-origin for clinicopathologic features of this disease. Cancer Res; 77(3); 802-12. ©2016 AACR.