tbuckley/cabot-search huggingface dataset:
Case 1-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, J. Warren Harthorne, John T. Fallon
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 42-year-old woman was admitted to the hospital under cardiopulmonary resuscitation.She was first seen in the clinic at the age of nine years because of infrequent nocturnal bouts of abdominal pain and vomiting of six months' duration. A murmur and "dropped beats" were noted, and she was referred to the Cardiac Clinic. There was a history of otitis media and sore throat, treated with penicillin. She had been delivered by cesarean section at eight months of gestation because of maternal renal disease and hypertension; she was not cyanotic at birth or thereafter. There was no history . . .
Eosinophil progenitor levels are increased in patients with active pediatric eosinophilic esophagitis
Authors: David W. Morris, Emily M. Stucke, Lisa J. Martin, J. Pablo Abonia, Vincent A. Mukkada, Philip E. Putnam, Marc E. Rothenberg, Patricia C. Fulkerson
Journal: Journal of Allergy and Clinical Immunology (2016)
Which Patients with Arm Oedema are Helped by Intermittent External Pneumatic Compression Therapy
Authors: G Newman
Journal: Journal of the Royal Society of Medicine (1988)

Twenty-two breast cancer patients with arm oedema answered a questionnaire to assess the efficacy of intermittent pneumatic compression therapy. Ten patients found the treatment useful, 12 were disappointed. A number of factors were analysed to find out whether it is possible to predict the outcome of treatment.
Abstract 4322: Kinase activity profiles distinguish papillary thyroid cancers with and without BRAF V600E mutations
Authors: Maria H. Hilhorst, Adrienne van den Berg, Tom van Wezel, Tim Kievits, Piet J. Boender, Rik de Wijn, Rob Ruijtenbeek, Wim Corver, Hans Morreau
Journal: Cancer Research (2015)

Abstract Background: Most differentiated non medullary thyroid cancers (DTC) are curatively treated by surgery and radio-active iodine ablation therapy. A subset of patients shows recurrence due to a loss of iodine transport. Two main subgroups of recurrent DTC are seen: papillary thyroid cancers (PTC) with somatic BRAF mutations (V600E) and oncocytic follicular cancer. Recurrent DTC are clinically treated by multi-kinase inhibitors such as sorafenib, with a low affinity for BRAF V600E. Vemurafenib and dabrafenib were specifically designed against this mutant. The aim of this study was twofold: - Can benign and malign DTC be classified based on kinase activity profiles? - Do sorafenib (and regorafenib) show different inhibition profiles than dabrafenib? Methods: Tissue cryosections from fresh frozen thyroid tumors were lysed. All tumor specimens were analyzed for BRAF mutations. Serine/threonine kinase (STK) activity profiles of the lysates (0.5 μg protein per array) were generated on PamChip® peptide microarrays, comprising peptide sequences from known human phosphorylation sites. The ex vivo effect of BRAF inhibitors sorafenib, regorafenib and dabrafenib on kinase activity profiles of 14 PTC's was determined as well. Data were analysed with Bionavigator software. Results: A classifier built on the STK kinase activity profiles of 57 thyroid cancer samples was able to classify malignant and benign tumors with a limited error rate. Leave One Out Cross Validation classified 26/35 of malignant and 17/22 of benign samples correctly. Kinase inhibition profiles of PTC's with sorafenib and regorafenib did not discrimate V600E mutants from wild type tumors whereas with dabrafenib 34/144 peptides were identified that potentially differentiated the groups. Conclusions: Serine/threonine kinase activity profiling appears to be able to differentiate benign and malignant thyroid tumors. Ex vivo spiking in of kinase inhibitors shows differential inhibition in tumors with a somatic BRAF mutation. Potentially, an industrial prediction platform can be envisioned for testing of novel drugs in tumor tissue. Whether individual patient responses against registered kinase inhibitors can be predicted must be investigated. Citation Format: Maria H. Hilhorst, Adrienne van den Berg, Tom van Wezel, Tim Kievits, Piet J. Boender, Rik de Wijn, Rob Ruijtenbeek, Wim Corver, Hans Morreau. Kinase activity profiles distinguish papillary thyroid cancers with and without BRAF V600E mutations. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4322. doi:10.1158/1538-7445.AM2015-4322
No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol O-methyltransferase activity
Authors: J K Daniels, N M Williams, J Williams, L A Jones, A G Cardno, K C Murphy, G Spurlock, B Riley, P Scambler, P Asherson, P McGuffin, M J Owen
Journal: American Journal of Psychiatry (1996)

Catechol O-methyltransferase (COMT) inactivates catecholamines by methylating their m-hydroxy group. Some previous studies using biochemical methods have found higher levels of COMT activity in schizophrenic patients. Recently, the genetic polymorphism that underlies variation in COMT activity, which results in the creation of a NlaIII restriction site in the low-activity allele, has been elucidated.This study investigated this polymorphism in 78 unrelated schizophrenic patients and 78 comparison subjects matched for age and ethnicity. High-molecular-weight DNA was isolated from lymphocytes with routine procedures, and each individual was typed for high and low COMT activity.The frequency of the NlaIII polymorphism was 0.51 in the schizophrenic patients and 0.53 in the comparison subjects, and no significant allelic or genotypic associations were observed.There was no evidence for variation in COMT activity between a group of schizophrenic patients and matched comparison subjects.
The magnitude of and health system responses to the mental health treatment gap in adults in India and China
Authors: Vikram Patel, Shuiyuan Xiao, Hanhui Chen, Fahmy Hanna, A T Jotheeswaran, Dan Luo, Rachana Parikh, Eesha Sharma, Shamaila Usmani, Yu Yu, Benjamin G Druss, Shekhar Saxena
Journal: The Lancet (2016)
On the Mechanism of Cancer Induction by Ultraviolet Radiation. II. A Quantitative Description and Its Consequences<xref ref-type="fn" rid="FN1">2</xref>
Authors: Harold F. Blum
Journal: JNCI Journal of the National Cancer Institute (1959)

A quantitative model is formulated which describes experimental data on the induction of cancer in albino mice by ultraviolet light. This model is based on the continuous acceleration of tumor growth by successive doses of radiation. Accepting the model either as describing such accelerated growth or as a strictly empirical fitting, one arrives at the conclusion that the process is continuous, cumulative, and essentially irreversible and nonthreshold.
Function of the transplanted heart.
Authors: L N Ivanova, L M Kuznetsova
Journal: BMJ (1980)

Clinical and functional results of orthotopic cardiac transplantation are analyzed. It is demonstrated that case follow-up with special non-invasive methods (ECG, Holter monitoring, high-resolution ECG, EchoCG, dopler-EchoCG) is mandatory for detection of cardiac transplant function, early diagnosis of chronic rejection crisis, timely and optimal treatment tactics.
Abstract P1-08-03: Association analysis of single-nucleotide polymorphisms in FANCD2-DNA damage repair pathway genes with breast cancer risk
Authors: F Chen, L Tang, J Huang
Journal: Cancer Research (2016)

Abstract Purpose: The aim of the study was to estimate breast cancer risk conferred by individual single-nucleotide polymorphisms (SNPs) of breast cancer susceptibility genes in the monoubiquitinated FANCD2–DNA damage repair pathway. Methods: We selected 48 tagging SNPs (tSNPs) from eight breast cancer susceptibility genes (TP53,PTEN,NBS1,BRIP1,PALB2,ATM,CHEK2 and RAD50) involved in the monoubiquitinated FANCD2–DNA damage repair pathway.The 48 tSNPs were genetyped by SNPscan in 734 women with breast cancer(534 sporadic cases and 200 early-onset and familial cases) and 672 sex- and age-matched healthy controls from Hunan and Sichuan Province of China.The odds ratio were calculated by logistic regression analysis under co-dominant model ,dominant model and recessive model respectively. Results: Forty-five tSNPs were successfully genotyped by SNPscan, and the call rates for each tSNP were above 98.9%. We found that 13 tSNPs of five genes (PALB2, TP53, NBS1, PTEN, and BRIP1) were significantly associated with breast cancer risk. A total of five tSNPs (rs2299941 of PTEN, rs2735385, rs6999227, rs1805812, and rs1061302 of NBS1) were tightly associated with breast cancer risk in sporadic cases, and five other tSNPs (rs1042522 of TP53, rs2735343 of PTEN, rs7220719, rs16945628, and rs11871753 of BRIP1) were tightly associated with breast cancer risk in early-onset and familial cases. We have not found significant tSNPs in the other three genes (ATM, RAD50, and CHEK2).Three tSNPs of TP53(rs12951053, rs1042522 and rs8064946),three tSNPs of BRIP1(rs16945628, rs7220719 and rs11871753) and rs2735343 of PTEN can significantly increase the risk of breast cancer,and most of these were under the analysis of early-onset and familial cases.Four tSNPs of NBS1(rs2735385, rs6999227, rs1805812 and rs1061302),rs2299941 of PTEN and rs513313 of PALB2 can significantly decrease the risk of breast cancer,and most of these were under the analysis of sporadic cases. Conclusions: Some of the tSNPs of five breast cancer susceptibility genes (PALB2, TP53, NBS1, PTEN, and BRIP1) involved in the monoubiquitinated FANCD2–DNA damage repair pathway were significantly associated with breast cancer risk in women from Hunan and Sichuan Province of China.Some locuses can increase breast cancer risk,and others can decrease breast cancer risk.But the majority of the tSNPs are located in the intron domain and their functions are unknown, so larger studies are needed to research the functions of these genes further. Citation Format: Chen F, Tang L, Huang J. Association analysis of single-nucleotide polymorphisms in FANCD2-DNA damage repair pathway genes with breast cancer risk. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-08-03.
Kidney Transplantation in Fabry's Disease
Authors: M Philippart, S S Franklin, D A Leeber, A R Hull, P C Peters
Journal: New England Journal of Medicine (1973)

The right abducens nerve palsy gradually improved.Six weeks after discharge lateral movement of the right eye was apparently full but the diplopia persisted and he complained of blurring in the left eye.Prednisolone was then given, but a week later vision in the right eye became blurred.The left carotid and the left radial pulses were absent and the right carotid pulse was weak.A short, soft systolic bruit was audible over the right carotid artery.Visual impairment was believed to be due to retinal ischaemia.Three months after discharge the patient still had headache and intermittent blurring of vision.The left auriculotemporal arterial pulsation was absent.Nicotinic acid added to the treatment gave no benefit.Four months after dischage he developed another crop of papulonecrotic eruptions over the back, buttocks, arms, legs, and face.The headache was intense and there was polyarthralgia involving the wrists, ankles, and knees.These symptoms persisted for over a month despite prednisolone in doses of up to 60 mg/day.Prednisolone was stopped and cyclophosphamide by mouth 150 mg/day gradually reducing to 100 mg/day was given instead.The headache became less frequent and less severe.Aortography nine months later showed the state of the extra- cranial cerebral vessels to be unchanged.
Prediction of Recurrence with the Recurrence Score in Pre- and Post-Menopausal Patients from the Pacs01 Trial
Authors: F. Penault-Llorca, T. Filleron, B. Asselain, F. Baehner, P. Fumoleau, M. Lacroix-Triki, S. Butler, F. Jamshidian, D. Cherbavaz, L. Roca, C. Sagan, J. Lemonnier, A. Martin, H. Roche
Journal: Annals of Oncology (2014)
Detection of 18F-FDG PET/CT Occult Lesions With 18F-DCFPyL PET/CT in a Patient With Metastatic Renal Cell Carcinoma
Authors: Steven P. Rowe, Michael A. Gorin, Hans J. Hammers, Martin G. Pomper, Mohammad E. Allaf, Mehrbod Som Javadi
Journal: Clinical Nuclear Medicine (2015)

Renal cell carcinoma (RCC) is common with more than 60,000 new cases in the United States yearly. No curative therapies are available for metastatic RCC. Improved methods of imaging metastatic RCC would be of value in identifying sites of occult disease and potentially for judging response to therapy. A 58-year-old man with known metastatic clear cell RCC was imaged with both 18F-FDG and 18F-DCFPyL PET/CT. 18F-DCFPyL is a small molecule inhibitor of the prostate-specific membrane antigen (PSMA), a target known to be highly expressed on solid tumor neovasculature. Relative to 18F-FDG, 18F-DCFPyL identified more lesions and demonstrated higher tumor radiotracer uptake.
Correspondence
Authors: R.J. Mann
Journal: British Journal of Dermatology (1982)

Journal Article Correspondence Get access R.J. Mann R.J. Mann Department of Dermatology, Royal Infirmary, Bristol Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 106, Issue 3, 1 March 1982, Page 373, https://doi.org/10.1111/j.1365-2133.1982.tb01740.x Published: 01 March 1982
Guidelines for the management of basal cell carcinoma
Authors: None Telfer, None Colver, None Bowers
Journal: British Journal of Dermatology (1999)

These guidelines on the management of basal cell carcinoma have been prepared for dermatologists on behalf of the British Association of Dermatologists. They present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of epidemiological aspects, diagnosis and investigation.
Traumatic Brain Injury — Football, Warfare, and Long-Term Effects
Authors: Steven T. DeKosky, Milos D. Ikonomovic, Sam Gandy
Journal: New England Journal of Medicine (2010)

In late July, the National Football League introduced a new poster to be hung in league locker rooms, warning players of possible long-term health effects of concussions. Public awareness of the pathological consequences of traumatic brain injury has been elevated not only by the recognition of the potential clinical significance of repetitive head injuries in such high-contact sports as American football and boxing, but also by the prevalence of vehicular crashes and efforts to improve passenger safety features, and by modern warfare, especially blast injuries. Each year, more than 1.5 million Americans sustain mild traumatic brain injuries with no loss . . .
THE ‘ANGIOGRAPHIC EVALUATION OF THE EVEROLIMUS-ELUTING STENT IN CHRONIC TOTAL OCCLUSIONS’ (ACE-CTO) STUDY
Authors: Anna Kotsia, Rachita Navara, Tesfaldet Michael, Daniel Sherbet, Michele Roesle, Aristotelis Papayannis, Georgios Christopoulos, Bavana Rangan, Vishal Patel, Eric Fuh, Owen Mogabgab, Deborah Shorrock, Atif Mohammad, Santiago Garcia, Calin Maniu, Ashish Pershad, Shuaib Abdullah, Jeffrey Hastings, Dharam Kumbhani, Michael Luna, Tayo Addo, Lorenza Makke, Jerrold Grodin, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2014)
Utility of Cancer Value Frameworks for Patients, Payers, and Physicians
Authors: Amitabh Chandra, Jason Shafrin, Ravinder Dhawan
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 2176: Joint structural variant analysis of colorectal cancer whole genome sequencing data
Authors: Esa Pitkänen, Tatiana Cajuso, Riku Katainen, Sofie Lundgren, Sari Tuupanen, Outi Kilpivaara, Lauri A. Aaltonen
Journal: Cancer Research (2015)

Abstract Colorectal cancer (CRC) is one of the most common cancers, with over million cases and over 600,000 deaths each year in the world. It is estimated that a significant part of CRCs may have a hereditary compo- nent, but majority of this heritability remains unexplained. Structural variants (SVs) comprise an important type of variation that, until the availability of deep-coverage whole-genome sequencing (WGS), has been hard to study in genome-wide scale. It has been suggested that a significant portion of unexplained, or “missing”, heritability could be explained by structural variants. Somatic structural aberrations are known to play a role in tumorigenesis and tumor progression. However, structural variation discovery is often complicated by low sequencing coverage, sequencing artifacts, repeat regions and errors of the reference genome. To study the role of structural variation in CRC, we analyzed deep-coverage WGS data of matched tumor-normal sample pairs of 213 Finnish CRC patients and additional in-house WGS data. In these data, we identified both germline and somatic structural variants using a recent structural variant caller DELLY. A novel algorithm was used to combine DELLY paired-end structural variant calls across normal and tumor samples to improve both sensitivity and specificity of variant detection. A total of 4,854,576 unfiltered structural events were identified, consisting of 2,912,552 deletions, 1,304,636 tandem duplications, 71,724 inversions and 565,664 interchromosomal translocations. To call high-confidence somatic events, we identified 475,902 structural events in tumors that were not present in any normal sample. Calling accuracy was further improved by annotating events by mappability and proximity to repeat regions. Our results demonstrate the applicability of integrating structural variant data across a large number of samples to obtain high-quality structural variant calls. Citation Format: Esa Pitkänen, Tatiana Cajuso, Riku Katainen, Sofie Lundgren, Sari Tuupanen, Outi Kilpivaara, Lauri A. Aaltonen. Joint structural variant analysis of colorectal cancer whole genome sequencing data. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2176. doi:10.1158/1538-7445.AM2015-2176
Amino acids in bipolar affective disorders: increased glycine levels in erythrocytes
Authors: S Rosenblatt, G E Gaull, J D Chanley, J S Rosenthal, H Smith, L Sarkozi
Journal: American Journal of Psychiatry (1979)

The authors measured the concentrations of 20 amino acids in the erythrocytes and plasma of 13 female bipolar patients and 10 female normal controls. The concentration of glycine in the erythrocyte was significantly elevated in the patient group. No differences were present in the plasma. Preliminary findings indicate that the high glycine levels were present in patients who were depressed, manic, or in remission and were unaffected by electroshock therapy.
Enzyme Histochemistry of the Human Thyroid Gland
Authors: S LINDSEY, I M ARICO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Embryonic Stem Cell Research
Journal: American Journal of Respiratory and Critical Care Medicine (2006)

It is generally acknowledged that research on stem cells derived from human embryos has the potential to dramatically increase our understanding and treatment of many common diseases. All clinical and research work involving human embryos in the UK is under the tight control of the Human Fertilisation and Embryological Authority (HFEA). Strict adherence to the HFEA Code of Practice ensures that the interests of patients, and their potential children, always remain priorities. All clinical and laboratory procedures involving human embryos are only permitted if the couple have given prior informed, written consent. Research on embryos that are not suitable for infertility treatment and would otherwise be discarded, is considered to be highly desirable. Already many couples have given consent for research using their embryos. It is the expressed wish of these couples that their embryos are used to progress research. The British Fertility Society represents over 800 doctors, scientists, nurses, counsellors and patients who are principally involved in the provision of fertility treatment in the UK. The expertise of these practitioners is an integral part of future stem cell research since it is spare embryos, created within fertility units, generously donated by infertility couples, which would be used as a source of stem cells. The Society has therefore examined all the implications of this research, both as they affect our patients directly and as they affect the wider community. On the basis of these considerations, we strongly support the Chief Medical Officer's recommendation in the UK to allow research in this area, which we anticipate will lead to new treatments for many devastating clinical problems. The public can be reassured that infertile couples will not be disadvantaged by such research.