tbuckley/cabot-search huggingface dataset:
SAT0529 Magnetic Resonance Imaging in Diffuse Idiopathic Skeletal Hyperostosis: Similarities to Axial Spondyloarthritis
Authors: U. Arad, O. Elkayam, I. Eshed
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Diffuse idiopathic skeletal hyperostosis (DISH) is a non-inflammatory condition that involves calcification and ossification of the spinal ligaments and entheses. In axial spondyloarthritis (SpA), an inflammatory disease associated with spinal ankylosis and enthesopathies, the pattern of new bone formation seen in the spine is different. While, characteristic magnetic resonance imaging (MRI) lesions of the spine in patients with SpA have been extensively described and defined<sup>1</sup>, there is a paucity of information regarding the MRI findings in DISH. <h3>Objectives</h3> To describe the MRI findings of patients with a radiographic diagnosis of DISH. <h3>Methods</h3> We collected computed tomography studies with findings characteristic of DISH (according to the classification criteria set by Resnick and Niwayama<sup>2</sup>) and that also had corresponding and concurrent MRI studies of the spine. For each patient, sagittal T1 and STIR MRI sequences were evaluated for anterior/posterior spondylitis and marrow fat depositions at the vertebral corners. <h3>Results</h3> Imaging studies of 10 patients had both radiographic evidence of DISH and available MRI studies of the spine. The male:female ratio was 4:1 and the median age was 70 years (range 64-82). The indications for imaging included back pain (n=4), trauma (n=2), suspected space occupying lesion (n=2), osteomyelitis (n=1) and atelectasis (n=1). Vertebral corner fat depositions were detected in 8 patients. In 3 of these patients, at least 3 vertebrae were involved, a finding suggestive of axial SpA according to the ASAS/OMERACT consensus statement<sup>2</sup>. Lesions consistent with anterior/posterior spondylitis at vertebral corners were detected in 3 patients, and in one patient lesions were detected in 3 separate vertebrae. <h3>Conclusions</h3> In a cohort of patients with DISH, about a third display spinal MRI lesions that are characteristic of axial spondyloarthritis. This bears relevance to cases with diagnostic uncertainty and may imply overlapping pathogenetic mechanisms for new bone formation in both SpA and DISH. Further study is indicated to better characterize the similarities and differences between the MRI lesions of DISH and SpA. <h3>References</h3> Hermann KG, Baraliakos X, van der Heijde DM, et al. Descriptions of spinal MRI lesions and definition of a positive MRI of the spine in axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI study group. Ann Rheum Dis. 2012;71:1278-88. Resnick D, Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH). Radiology. 1976;119:559-568. <h3>Disclosure of Interest</h3> None Declared
Impact of food animal trade on the spread of mcr-1-mediated colistin resistance, Tunisia, July 2015
Authors: Raoudha Grami, Wejdene Mansour, Wahib Mehri, Olfa Bouallègue, Noureddine Boujaâfar, Jean-Yves Madec, Marisa Haenni
Journal: Eurosurveillance (2016)

We report a high prevalence of MCR-1 and CTX-M-1-producing Escherichia coli in three Tunisian chicken farms. Chickens were imported from France or derived from French imported chicks. The same IncHI2-type plasmid reported to carry those genes in cattle in France and in a food sample in Portugal was found in Tunisian chickens of French origin. This suggests a significant impact of food animal trade on the spread of mcr-1 -mediated colistin resistance in Europe.
P16.27 * DIFFERENTIATING BRAIN RADIONECROSIS FROM TUMOR RECURRENCE: A ROLE FOR CONTRAST ENHANCED ULTRASOUND (CEUS)? CASE REPORT
Authors: L. Mattei, F. Prada, F. Legnani, C. Casali, A. Filippini, A. Perin, M. Saini, A. Saladino, I. Vetrano, F. DiMeco
Journal: Neuro-Oncology (2014)

BACKGROUND: Differentiating radionecrosis from local tumor recurrence is a major concern in the management of patients harbouring a cerebral tumor and treated with radiotherapy. In these cases, contrast-enhanced MRI usually shows ambiguous enhancement, while advanced imaging techniques (MRI spectroscopy, DWI, DTI, perfusion and PET) are still far from being validated as a reliable alternative to biopsy and histological assessment. CASE REPORT: We report the case of a patient who underwent cyberknife radiosurgery (21Gy) for a left rolandic brain metastasis from a lung carcinoma. Four months after radiotherapy, she started experiencing a progressive worsening of her upper right limb's strenght, with a neuroradiological evidence at serial MRIs of a progressive enhancing rolandic lesion. The patient underwent surgical removal of the lesion at our Neurosurgical Division: neurophysiological monitoring, standard B-mode UltraSonography and Contrast-Enhanced UltraSonography (CEUS) were performed intraoperatively to assist in tumor resection. Very interestingly, CEUS did not show any enhancement of the pathologic tissue, differently from what is expected for brain metastases, as reported in previous studies. Histopathological examination showed nervous tissue with post-treatment radiation effects (radionecrosis) with a few metastatic cells. DISCUSSION: Contrast-Enhanced UltraSound is progressively becoming a widespread tool in neurosurgery. Previous studies have described the contrastographic pattern of different cerebral lesions, including metastases. Surprisingly, despite a strong uptake of contrast agent at MRI, we observed that radionecrotic tissue did not show any enhancement at CEUS. For the first time we report the appearance of radionecrosis at CEUS; the lack of contrast enhancement could represent an important hallmark in differential diagnosis with neoplastic tissue. Moreover, in this report, the use of CEUS was confined to the intraoperative stage; however, new approaches to transcranial ultrasonography could extend the value of this technique to the bedside decision-making process. CONCLUSION: Of course, further investigation is required beyond this case report; nonetheless the findings here reported suggest that CEUS could become a promising tool in helping differentiating radionecrosis from tumor recurrence.
Helicobacter pylori Seroprevalence and Colorectal Neoplasia: Evidence Against an Association
Authors: S. F. Moss, A. I. Neugut, G. C. Garbowski, S. Wang, M. R. Treat, K. A. Forde
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Helicobacter pylori Seroprevalence and Colorectal Neoplasia: Evidence Against an Association Get access Steven F. Moss, Steven F. Moss Divison of Gastroenterology, Department of Medicine, St. Luke's/Roosevelt Hospital CenterNew York, N.Y. Correspondence to : Steven F. Moss, M.D., Division of Gastroenterology. Department of Medicine, St. Luke's/Roosevelt Hospital. 1111 Amsterdam Ave., New York, NY 10025. Search for other works by this author on: Oxford Academic PubMed Google Scholar Alfred I. Neugut, Alfred I. Neugut Department of Medicine and School of Public Health, Columbia-Presbyterian Medical CenterNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Gail C. Garbowski, Gail C. Garbowski Department of Medicine and School of Public Health, Columbia-Presbyterian Medical CenterNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Shaobai Wang, Shaobai Wang Divison of Gastroenterology, Department of Medicine, St. Luke's/Roosevelt Hospital CenterNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael R. Treat, Michael R. Treat Department of Surgery, Columbia-Presbyterian Medical CenterNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenneth A. Forde Kenneth A. Forde Department of Surgery, Columbia-Presbyterian Medical CenterNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 10, 17 May 1995, Pages 762–763, https://doi.org/10.1093/jnci/87.10.762 Published: 17 May 1995 Article history Received: 05 December 1994 Revision received: 27 January 1995 Accepted: 31 January 1995 Published: 17 May 1995
Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma
Authors: Chioniso Patience Masamha, Todd R. Albrecht, Eric J. Wagner
Journal: Journal of Hematology & Oncology (2016)

The t(11;14) translocation resulting in constitutive cyclin D1 expression is an early event in mantle cell lymphoma (MCL) transformation. Patients with a highly proliferative phenotype produce cyclin D1 transcripts with truncated 3′UTRs that evade miRNA regulation. Here, we report the recurrence of a novel gene fusion in MCL cell lines and MCL patient isolates that consists of the full protein coding region of cyclin D1 (CCND1) and a 3′UTR consisting of sequences from both the CCND1 3′UTR and myotonic dystrophy kinase-related Cdc42-binding kinase's (MRCK) intron one. The resulting CCND1/MRCK mRNA is resistant to CCND1-targeted miRNA regulation, and targeting the MRCK region of the chimeric 3′UTR with siRNA results in decreased CCND1 levels.
Abstract 1853: PDE5 suppression selectively induces apoptosis of human breast tumor cells and attenuates Wnt/β-catenin mediated transcription
Authors: Heather N. Tinsley, Adam B. Keeton, Wenyan Lu, Yonghe Li, Gary A. Piazza
Journal: Cancer Research (2011)

Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) such as sulindac sulfide (SS) display promising antineoplastic properties in experimental models, but toxicities from cyclooxygenase (COX) inhibition limit their clinical use for cancer chemoprevention. While COX inhibition is responsible for the anti-inflammatory activity of SS, recent studies suggest that phosphodiesterase (PDE) 5 inhibition and activation of cGMP signaling are closely associated with its ability to induce apoptosis of tumor cells. However, the underlying mechanisms responsible for apoptosis induction and factors that influence sensitivity to SS have not been well studied. Here we show that SS can induce apoptosis of breast tumor cells that express PDE5, but not normal mammary epithelial cells, which do not express PDE5. Inhibition of PDE5 and subsequent activation of PKG by SS was associated with increased β-catenin phosphorylation, decreased β-catenin mRNA and protein levels, reduced β-catenin nuclear localization, decreased Tcf/Lef promoter activity, and decreased expression of Wnt/β-catenin regulated proteins such as survivin. Suppression of PDE5 by siRNA or known PDE5 inhibitors was sufficient to selectively induce apoptosis and attenuate β-catenin mediated transcription in breast tumor cells with no effect on normal mammary epithelial cells. These findings provide evidence that PDE5 expression can influence the sensitivity of human breast tumor cells to SS and that cGMP can inhibit Wnt/β-catenin signaling and suppress the transcription of key apoptosis regulatory proteins. We conclude that PDE5 represents a novel molecular target for the discovery of safer and more efficacious drugs for the prevention and treatment of breast cancer. Funding provided by NIH/NCI grants CA131378 and CA148817. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1853. doi:10.1158/1538-7445.AM2011-1853
PERIOPERATIVE ADVERSE OUTCOMES IN PATIENTS WITH ATRIAL FIBRILLATION TAKING EDOXABAN OR WARFARIN: ANALYSIS OF THE ENGAGE AF-TIMI 48 TRIAL
Authors: James Douketis, Jeffrey Weitz, Sabina Murphy, Naveen Deenadayalu, Andrea Elizabeth Crompton, Michele Mercuri, Christian Ruff, Elliott Antman, Robert Giugliano
Journal: Journal of the American College of Cardiology (2015)
THU0247 Home: The effect of systemic sclerosis on the blood flow in the hands
Authors: H. Knaapen, A.E. Voskuyl, P.L. van Daele, J.P.J. Bloemsaat-Minekus, M.C. Vonk, A.J.M. Schuerwegh
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patients with scleroderma (SSc) have a significant reduction of blood flow in the hands, compared to healthy controls (Rosato et al.2010). The relationship between the blood flow and the presence of digital ulcers (DU) or pitting scars (PS) is currently unknown. <h3>Objectives</h3> The aim of this study is to obtain better understanding of the blood flow in the hands of SSc patients. <h3>Methods</h3> The blood flow in both hands in healthy volunteers (n=52) and SSc patients (n=56) with a history of DU in the previous 2 years was assessed with the PeriScan PIM 3 laser Doppler (Perimed, Sweden). The hand was categorized into 3 separate regions: ROI1, distal to the PIP joint of the 3 middle fingers; ROI2, distal to the metacarpal joints and proximal to the PIP joint and ROI 3, the hand proximal to the metacarpal joints. The patients were divided into 4 groups: no current DU or PS (NO) (n=10); PS only (PS) (n=25), new DU (&lt;3 mo) (DU-new) (n=9), persistent DU (&gt;3mo) (DU-pers) (n=8). MEC approval was obtained. The study is registered in clinicaltrials.gov (NCT01395732). <h3>Results</h3> The healthy volunteers were younger compared to SSc patients (45±16 versus 55±12), whereas no difference in age was found between the SSc patients groups. The blood flow in all 3 defined regions varied widely within both the healthy volunteer group andthe SSc patient groups. The blood flow distal to the interphalangeal joint was significantly lower for all SSc patients compared to healthy controls (74,0±24,4 vs 62,4±28,8, p=0.003). The blood flow tended to be higher for patients with new DU’s compared to patients with persistent DU’s. In healthy subjects, the perfusion gradient descended between ROI1, ROI2 ROI3. This descent was less pronounced in SSc patients and virtually absent in patients with persistent DU’s. <h3>Conclusions</h3> Individual perfusion of the hands shows a wide variation, both in healthy volunteers and in SSC patients. The extent of the DU disease seems to effect the blood flow; however more data are needed to confirm this. <h3>References</h3> Rosato et al. Bosentan Improves Skin Perfusion of Hands in Patients with Systemic Sclerosis with Pulmonary Arterial Hypertension. J. Rheumatol 2010; 37(12)2531-9. <h3>Disclosure of Interest</h3> H. Knaapen: None Declared, A. Voskuyl: None Declared, P. van Daele: None Declared, J. Bloemsaat-Minekus Employee of: Actelion Pharmaceuticals Nederland B.V., M. Vonk: None Declared, A. Schuerwegh: None Declared
P594Role of autophagy in chloramphenicol-induced cardioprotection
Authors: G Koncsos, Z Giricz, A Gorbe, RA Gottlieb, P Ferdinandy
Journal: Cardiovascular Research (2014)

Purpose: We have shown previously that chloramphenicol (CAP) reduces infarct size, although its mechanism is not fully understood. It has also been evidenced that autophagy plays important role in cardioprotection. Therefore, our aim was to investigate whether autophagy is necessary for CAP-induced cardioprotection.
Abstract 4368: Targeting of head and neck cancer stem cells using salinomycin
Authors: Selena Z. Kuo, Katherine J. Blair, Eric L. Abhold, Alan Kiang, Martin Haas, Jessica Wang-Rodriguez, Weg M. Ongkeko
Journal: Cancer Research (2011)

Abstract Cancer stem cells are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Gupta and colleagues recently reported that salinomycin, a livestock antibiotic, selectively targets breast cancer stem cells. In our study we sought to determine the effect of salinomycin on head and neck squamous cell carcinoma (HNSCC) stem cells. We observed that salinomycin inhibits self-renewal capacity in HNSCC stem cells, as shown by a dose-dependent decrease in sphere formation. In addition, treatment with salinomycin resulted in a decrease in mRNA expression of the stem cell markers CD44 and BMI-1, both of which are critical for maintaining tumorigenicity in HNSCC. In combination with the chemotherapeutic agents cisplatin and doxorubicin, salinomycin synergistically killed HNSCC cancer stem cells more effectively compared to either drug alone, as demonstrated by cell proliferation and TUNEL assays. High-throughput analysis revealed a set of differentially expressed microRNAs in salinomycin-treated HNSCC stem cells, warranting further investigation into the possibility of microRNA-mediated pathways that are regulated by salinomycin. Taken together, our findings indicate promise for using salinomycin or related derivatives as a novel treatment for HNSCC, although further studies are needed to confirm efficacy in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4368. doi:10.1158/1538-7445.AM2011-4368
Concentration of 3′, 5′ Cyclic Adenosine Monophosphate in Ventricular Cerebrospinal Fluid of Patients with Prolonged Coma after Head Trauma or Intracraneal Hemorrhage
Authors: Daniel Rudman, Alan Fleischer, Michael H. Kutner
Journal: New England Journal of Medicine (1976)

Original Article from The New England Journal of Medicine — Concentration of 3′, 5′ Cyclic Adenosine Monophosphate in Ventricular Cerebrospinal Fluid of Patients with Prolonged Coma after Head Trauma or Intracraneal Hemorrhage
NI-72 * CORRELATION OF VOLUMETRICAL ANALYSES DERIVED FROM 18FET-PET AND MRI WITH OUTCOME IN GLIOBLASTOMA PATIENTS
Authors: B. Suchorska, N. L. Jansen, M. Sosnova, H. Janssen, M. Grabowski, F.-W. Kreth, M. A. Vogelbaum, J.-C. Tonn
Journal: Neuro-Oncology (2014)

AIM: Both MRI and PET have been increasingly used for monitoring treatment response and adjustment of therapeutic strategies in glioma. The purpose of the currentstudy was to elucidate a possible prognostic influence of the initial tumor volume derived both from 18FET-PET as well as MRI on outcome in de-novo glioblastoma (GBM) patients. PATIENTS AND METHODS: 71 patients with newly diagnosed GBM who received 18FET-PET and MRI prior to microsurgery/biopsy and subsequent radio/chemotherapy according to the EORTC/NCIC protocolwere analysed. After co-registration, volumetrical analysis was performed on MRI and 18FET-PET data. Biological tumor volume (BTV) was defined on 18FET-PET using brain-to tumor ratio of 1.6. For MRI,T2/FLAIR as well as Gd-enhanced T1-weighted sequences with and without necrotic parts were correspondingly obtained in each patient. Correlation of initial tumor volume on each image modality with overall survival and progression free survival was performed. Log rank test was used for statistical analysis. RESULTS: Volumetrical analyses revealed the following distribution pattern: FLAIR volume > BTV1.6 >Gd-enhanced T1 volume with necrosis >Gd-enhanced T1 volume without necrosis. Patients with smaller BTV1.6 experienced longer OS and PFS (p= 0.01/0.03), while Gd-enhanced T1-weighted MRI without necrosis was the only MRI parameter associated with an improved OS and PFS (p = 0.03/p = 0.05). CONCLUSION: Biological tumor volume as determined by 18FET-PET and Gd-enhanced T1 volume without necrosis are associated with outcome in GBM. BTV seems to surmount volumetry obtained by conventional MRI techniques in depicting vital tumor tissue. This research was in part supported by Deutsche Krebshilfe/GGN/ 70-3163-Wi 3
SERUM LACTATE INCREASE DURING HOSPITALIZATION AFTER TEMPORARY CIRCULATORY SUPPORT WITH THE IMPELLA LP5.0 IS AN INDEPENDENT PREDICTOR OF 30-DAY MORTALITY FOR PATIENTS WITH ACUTE LEFT VENTRICULAR CARDIOGENIC SHOCK
Authors: Kayan Lam, Khibar Salah, Aria P. Yazdanbakhsh, Wim Lagrand, José Henriques, Bas de Mol
Journal: Journal of the American College of Cardiology (2016)
Abstract 3974: TIAF1 blocks p53 suppression of SMAD promoter activation
Authors: Nan-Shan Chang, Li-Jin Hsu, Ming-Hui Lee, Sing-Ru Lin
Journal: Cancer Research (2010)

Abstract p53 participates in the TGF-β signaling. How p53 regulates SMAD gene transcription is largely unknown. TIAF1 is a TGF-β1-induced factor and a downstream effector of the TGF-β signaling. TIAF1 is known to control nuclear localization of Ser15-phosphorylated p53. Ectopic TIAF1 induces growth inhibition and apoptosis of monocytic U937 and many non-fibroblasts, via upregulation of p53, p21, and Smad2/4, but downregulation of ERK phosphorylation. Wild type p53 suppresses the transcriptional activation of SMAD gene, whereas isoform p53γ induces the gene activation. TGF-β1 increases the physical association of TIAF1 with Smad4, and when overexpressed, TIAF1 inhibits Smad4-dependent promoter activation. In combination, TIAF1 and p53 support the promoter activation regulated by endogenous or ectopic Smad4, indicating that TIAF1 blocks p53 suppression of the SMAD promoter activation, and vice versa. Without Ser46 phosphorylation in p53 (p53ΔS46), p53ΔS46 alone, or in the co-presence of TIAF1, abolishes the Smad4-regulated promoter activation. These observations suggest a critical role of Ser46 in p53 in controlling SMAD transcriptional activation. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3974.
<i>Bacillus cereus</i>Food Poisoning
Authors: William Terranova, Paul A. Blake
Journal: New England Journal of Medicine (1978)

BACILLUS cereus is an aerobic spore-forming, motile, gram-positive rod1 that has been recognized as a cause of food-borne disease with increasing frequency in recent years. The organism was conclusively implicated by Hauge in Norway in the early 1950's.2 The illnesses were characterized by an incubation period averaging 10 to 12 hours, and abdominal pain, profuse watery diarrhea, tenesmus and nausea usually lasting not longer than 12 to 24 hours. Vomiting and fever were unusual. Outbreaks of similar illnesses attributed to B. cereus were subsequently reported throughout northern and eastern Europe.3 In 1974 Mortimer and McCann4 reported several outbreaks of a . . .
Commentary: Improving the Management of Environmental Health
Authors: Lester B. Lave
Journal: Environmental Health Perspectives (1985)

Environmental health regulation has been developed on the premise that both problems and solutions are obvious, requiring only attention and commitment. The result has been impossible legislative goals and frenetic, unfocused agency efforts to deal with too many issues. Preventing all environmental health problems is impossible and not the best approach; instead, attention ought to be shifted toward reacting quickly to problems before irreversible, severe health damage has occurred. Rather than having regulatory agencies attempt to manage all problems, they should be focused on exemplifying goals and productive approaches, and on handling a few major issues. Regulatory agencies should be managing the nonregulatory institutions to ensure that they are effective in dealing with the myriad issues that the agencies will never be able to handle. The inherent limitations of federal regulatory agencies must be recognized to restructure environmental health management to be more effective in lowering risks while being efficient, administratively simple, and more equitable.
CENTRAL PULSE PRESSURE AND ITS HEMODYNAMIC DETERMINANTS IN MIDDLE-AGED ADULTS WITH IMPAIRED FASTING GLUCOSE AND DIABETES MELLITUS: THE ASKLEPIOS STUDY.
Authors: Julio A. Chirinos, Patrick Segers, Thierry C. Gillebert, Marc De Buyzere, Caroline M. Van daele, Zubair A. Khan, Muhammad U. Khawar, Dirk De Bacquer, Ernst R. Rietzschel
Journal: Journal of the American College of Cardiology (2013)