tbuckley/cabot-search huggingface dataset:
AB0930 The Pachydermoperiostosis: Clinical and Radiologic Characteristics (About 6 Cases)
Authors: Z. Alaya, D. Amri, K. Baccouche, H. Zaghouani, M. Bouzaouach, S. Belghali, H. Zaglaoui, E. Bouajina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The pachydermoperiostosis is a rare genetic disorder. This is the primitive and idiopathic form of the hypertrophic osteoarthropathy (HOA). The disease is characterised clinically by digital clubbing and hypertrophic skin changes, seborrhoea with hyperhidrosis, and arthralgia or arthritis. This disease can be a differential diagnosis with secondary HOA and chronic inflammatory rheumatism. <h3>Objectives</h3> The objective of our study was to describe the clinical and radiological aspects of pachydermoperiostosis. <h3>Methods</h3> This is a retrospective study of 6 cases of pachydermoperiostosis collected in the Department of Rheumatology over a period of 14 years [2000-2014]. <h3>Results</h3> Our population consists of 6 men. The mean age was 27.5 years. Five patients complained of inflammatory arthralgias and one patient of polyarthritis. Skin thickening (pachyderma) was observed in all cases. The skin of the hands and feet showed excessive sweating in 4 cases. Finger clubbing was noted in 5 cases. Excessive sebaceous secretions was observed in 2 cases. Inflammation tests were disturbed in 4 cases. Hypergammaglobulinemia was present in one case. The skeletal X-ray documented marked periosteal thickening of the long bones and sacro-iliac osteosclerosis (periostosis) in all cases. Bone scintigraphy showed intense hyperfixation of the long bones and sacro-iliac joints. After excluding secondary causes, primary HO diagnosis was established. The treatment consisted of analgesics in all cases, NSAIDs in 2 cases and tamoxifen in 2 cases. <h3>Conclusions</h3> Pachydermoperiostosis is a rare hereditary disorder, which affects both bones and skin. It is characterized by a combination of dermatologic changes (pachydermia or thickening of the skin) and rheumatologic manifestations (periostosis and finger clubbing). <h3>Disclosure of Interest</h3> None declared
Life-saving first aid tips in the palm of your hands…courtesy of the Red Cross
Authors: Jason J Wilson, William D J Johnston, Mark A Tully
Journal: British Journal of Sports Medicine (2016)

First Aid by British Red Cross

Health and fitness

Android (2.2 and above), iOS (8.0 and above), Windows phone (8.1 and 10)

Free

The ‘First Aid by British Red Cross’ app has been designed to enable members of the public to learn appropriate first aid management, before and during an emergency.1 The British version of the First Aid app has been adapted for use in 76 countries.1

The First Aid app is divided into five sections. The ‘Learn’ section (figure 1) contains easy-to-understand advice for 18 different emergency situations, each presented using key points and animations. Each situation is summarised using 15–30 s video clips, which facilitates different learning styles. To supplement the key points, FAQs are also included for those wanting further knowledge. The ‘Prepare’ section gives detailed advice on being ready to deal with 13 different emergency situations. Advice for essential items for inclusion …
Sialorrhea as a side effect of lithium: a case report
Authors: S R Donaldson
Journal: American Journal of Psychiatry (1982)

A 37-year-old male patient developed sialorrhea while being treated with lithium carbonate. The sialorrhea was associated with salivary gland enlargement and was reversed by discontinuation of lithium. Concomitant treatment with propantheline bromide provided symptomatic relief.
Care Quality Commission’s unfair treatment of Addenbrooke’s Hospital
Authors: Nick Mann
Journal: BMJ (2015)

There is no contextual explanation to justify why Addenbrooke’s Hospital was put into special measures by the Care Quality Commission (CQC), forcing the loss of its chief executive officer and distracting focus from patient care to satisfying the inspectorate.1

So their new electronic patient record system didn’t work properly when it was rolled out; neither did universal …
The X Factor
Authors: A S Grove
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnetically softened iron oxide (MSIO) nanofluid and its application to thermally-induced heat shock proteins for ocular neuroprotection
Authors: Seongtae Bae, Jin Wook Jeoung, Minhong Jeun, Jung-Tak Jang, Joo Hyun Park, Yu Jeong Kim, Kwan Lee, Minkyu Kim, Jooyoung Lee, Hey Min Hwang, Sun Ha Paek, Ki Ho Park
Journal: Biomaterials (2016)
SAT0616 Current Smoking and Hypertension are Associated with Persistent Power Doppler Ultrasound (PDUS) Signals at 12 Months in Patients with Inflammatory Arthritis
Authors: J. Callhoff, K. Albrecht, A. Zink, M. Backhhaus
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Muskuloskeletal ultrasound (US) is used for the detection of inflamed soft tissue and erosive changes in patients with inflammatory joint diseases. <h3>Objectives</h3> To evaluate patient-related correlates to persistent power Doppler ultrasound (PDUS) signals and to the development of new erosions at 12 months. <h3>Methods</h3> A total of 160 patients with early inflammatory arthritis (symptoms &lt;6 months) were followed-up by musculoskeletal ultrasound (US) at 0 and 12 months. A structured protocol of validated US items was used on the basis of the US7 score [1], including the B-mode and PDUS examination of the clinically most affected hand and foot (wrist, ECU, MCP2,3 and MTP2,5). The results were graded semiquantitatively (0-3). A sumscore was obtained from all synovitis gradings in B-Mode (0-21) and PDUS (0-21). Erosions were reported as present/absent in wrist and MCP2,3 (0-3). Correlates of a PDUS score ≥1 and novel erosions at 12 months were determined using logistic regression analyses. <h3>Results</h3> At baseline, 126 patients (79%) presented with a B-mode sumscore ≥2 and 108 patients (68%) had a PDUS sumscore ≥1. The mean clinical values at baseline were: age: 56 years, symptom duration: 13 weeks, DAS28: 5.1, ESR: 31mm/h, SJC: 7, TJC: 11. At 12 months, a total of 33 patients (21%) had an ongoing PDUS score &gt;1 that correlated with ongoing clinical activity (mean ESR 27mm/h, SJC 4). In the multivariate logistic regression analysis, current smoking (OR 3.1), hypertension (OR 2.9) and the TJC (OR 1.1) were significantly associated with a PDUS score &gt;1 at 12 months. The development of new erosions (in 12 (5%) of the patients) at 12 months was associated with a high B-mode synovitis score &gt;6 (OR 12.1, p&lt;0.01). <h3>Conclusions</h3> Current smoking and hypertension increase the probability to have persistent PDUS activity in inflammatory arthritis. As both can cause endothelial damage, an increasing vulnerability of the synovial tissue can be expected. <h3>References</h3> Backhaus M, Ohrndorf S, Kellner H, et al. Evaluation of a novel 7-joint ultrasound score in daily rheumatologic practice: a pilot project. Arthritis Rheum. 2009 Sep 15;61(9):1194-201. <h3>Acknowledgements</h3> The observational cohort was funded by an unconditional grant from Pfizer. <h3>Disclosure of Interest</h3> None declared
PWE-200 Metabolomic profiling in pancreatic cancer; in search of new biomarkers
Authors: NP Ross, E Correa, N Rattray, D Hildebrand, Y Xu, D Trivedi, R Goodacre, AJM Watson
Journal: Gut (2015)

<h3>Introduction</h3> Pancreatic cancer is a devastating disease with a poor outcome. Current biomarkers fall short in accessibility, sensitivity, specificity and their ability to distinguish malignant from benign conditions. Metabolomics aims to decipher molecular signatures that will distinguish disease from controls, ultimately leading to novel targets for diagnosis and treatment. The aim of this novel study was to characterise potentially new pancreatic cancer biomarkers. <h3>Method</h3> Urine and serum samples from 32 patients with pancreatic cancer (PC), were compared with healthy controls and patients with chronic pancreatitis and benign jaundice. Two analytical platforms, UHPLC-MS and GC-TOF-MS, were used in this study in order to minimise false negatives and identify a quantitative compliment of all metabolites across a wide molecular weight range. GC-TOF-MS can identify very low molecular weight polar metabolites &lt;350 Da, where-as reverse phase UHPLC-MS is useful in resolving and detecting non-polar metabolites. Subsequent metabolite identification was subject to univariate and multivariate analysis (p &lt; 0.05). <h3>Results</h3> After univariate analysis, a total of 747 serum metabolites and 638 urinary metabolites were identified as significantly different in comparison to healthy controls. When chronic pancreatitis and benign jaundice controls were used for comparison to pancreatic cancer then 185 and 176 serum and 333 and 51 urinary metabolites were identified as statistically significant at differentiating these groups respectively. Multivariate analysis showed good discrimination between resectable and non-resectable cases, based on metabolite profile. Urine profiles, in particular, showed consistent separation between resectable and non-resectable disease. When participants without definitive pathology were removed from analysis, the separation improved further. It was so clear that only an unsupervised PCA analysis was sufficient to visualise group separation. Importantly there did not seem to be any effect from diabetes or jaundice on the differentiation of metabolite profiles. <h3>Conclusion</h3> In this novel study, metabolite profiling can distinguish patients with pancreatic cancer from controls. Furthermore, multivariate analysis of metabolite profiles is able to distinguish resectable from irresectable disease with 95% confidence intervals. Multiple putative biomarkers have been identified and will be presented. <h3>Disclosure of interest</h3> None Declared.
AB0832 Serum Levels of Aggrecan Args, Nitege Fragments in Tunisian Patients with Knee Osteoarthritis: Clinical, and Radiological Correlation
Authors: A. Bahlous, E. Kalai, H. Sahli, L. Laadhar, M. Mrad, K. Bouzid, I. Cheour, M. Chelly
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Proteolytic degradation of aggrecan is a hallmark of the pathology of osteoarthritis. In this study, we analyzed the markers of degradation aggrecan for the first time in an African osteoarthritis population <h3>Objectives</h3> The aim of this study was to evaluate the relationship between the value of new markers of aggrecan degradation (ARGS, NITEGE) fragments and clinical and radiological progression of knee osteoarthritis (OA) in Tunisian population. <h3>Methods</h3> We measured serum levels of ARGSV and NITEGE in 125 women with knee osteoarthritis (mean ± SD age of 53.6±7.6 years, mean ± SD disease duration of 3.6±3.8 years), and 57 women age-matched controls underwent Lyon Schuss X-ray exams. Two experienced readers independently measured the joint space width (JSW) and classified each knee for severity using the Kellgren/Lawrence (KL) scale. We investigated the relationships between these two aggrecan degradations fragments and urinary CTX-II levels. The serum levels of aggrecan ARGS, NITEGE fragments and urinary concentration of CTX-II was measured by a competitive ELISA. <h3>Results</h3> Median serum ARGSVI (by 18%; p=0.002), and NITEGE (36.4%; p&lt;0.001) levels were significantly decreased in patients with knee osteoarthritis compared with controls. Minimal joint space width was negatively correlated with ARGSV (r = –0.368, p=0.04) and NITEGE (r = –0.274, p=0.038) in knee osteoarthritis patients. Serum ARGSV was correlated with KL scale (r =0.28, p=0.03), disease duration (r = -0.24, P=0.04) and BMI (r =0.18, p=0.04). Median urinary CTX-II levels were significantly increased by 39.5% (p=0.001) in knee OA patients compared with controls. <h3>Conclusions</h3> These markers can be used to monitor aggrecanase activity in human joint disease. Their combination with CTX-II can improve clinical investigation of patients with osteoarthritis patients. <h3>References</h3> Joint Bone Spine 2012; 79 (6): 610-5. Arthritis Res Ther 2010; 12: R230. <h3>Disclosure of Interest</h3> None declared
CHEMISTRY AND ENDOCRINOLOGY
Authors: L P LATASH, D R SHTULMAN
Journal: JAMA (1927)

It is a fundamental requisite of any complex working structure, whether a man-made machine or a living body, that the various components shall act in a harmonious manner. If they function independently, the mechanism as a whole will presumably fail to accomplish the purposes for which it was designed. In fact, unharmonious action may even lead to disaster if one part works in discord or possibly in actual antagonism to another. Dysfunction is a dangerous manifestation for the continued welfare of the mechanism. Discord in the action of the component structures may in the long run destroy the machine that was destined for perfect, well ordered performance. In a stimulating address before Chicago chemists on the occasion of the award of the Gibbs medal to him, Professor Abel<sup>1</sup>of Johns Hopkins University intimated that the significance of the interdependence of the various mechanisms of the animal body, of their
PTH-196 Chronic cholestasis and parenteral nutrition: prevalence and effect of bowel restoration surgery
Authors: F Adaba, F Iqbal, C Vaizey, S Gabe, J Warusavitarne, J Nightingale
Journal: Gut (2015)

<h3>Introduction</h3> Patients with mesenteric infarction can have intestinal failure due to a short bowel thereby needing parenteral nutrition. A short bowel and parenteral nutrition can increase the risk of chronic cholestasis. Restoring bowel continuity after a mesenteric infarction results in reduction or stopping parenteral nutrition requirements. The aims of this study are to determine the prevalence and the effect of restoring bowel continuity on chronic cholestasis. <h3>Method</h3> A retrospective review of patients with a short bowel due to mesenteric infarction from 2000–2012. We defined chronic cholestasis as two of bilirubin, alkaline phosphatase and gamma-glutamyl transferase being 1.5 times the upper limit of normal for more than 6 months. <h3>Results</h3> One hundred and four (55 females, median age 54 years) patients were identified. Seventy three (70%) patients had bowel continuity restored while 31 (30%) patients did not have bowel continuity restored. The prevalence of chronic cholestasis was 29%. Fifteen (21%) of 73 patients had chronic cholestasis. Following restoration of bowel continuity, 8 (53%) of 15 patients had a return of liver biochemistry to normal range within a year. Univariate analysis showed restoring bowel continuity (p = 0.002) was associated with a reduced risk of chronic cholestasis. Multivariate analysis showed cessation of PN was a significant factor in reducing chronic cholestasis (p = 0.02). <h3>Conclusion</h3> The prevalence of chronic cholestasis is 29% for patients with a short bowel receiving parenteral nutrition. Chronic cholestasis resolves in over half patients after continuity is restored. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Cavicchi M, Beau P, Crenn P, <i>et al</i>. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. <i>Ann Intern Med</i>. 2000;132(7):525–32 Lloyd DAJ, Zabron AA, Gabe SM. Chronic biochemical cholestasis in patients receiving home parenteral nutrition: prevalence and predisposing factors. <i>Aliment Pharmacol Ther</i>. 2008;27(7):552–60 Nightingale JM. Management of patients with a short bowel. <i>World J Gastroenterol</i>. 2001;7(6):741–51 Salvino R, Ghanta R, Seidner DL, <i>et al</i>. Liver failure is uncommon in adults receiving long-term parenteral nutrition. <i>J Parenter Enter Nutr</i>. 2006;30(3):202–8
A Study of the Sensitivity of the Mouse Forestomach Toward Certain Polycyclic Hydrocarbons&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Fred G. Bock, Douglas W. King
Journal: JNCI Journal of the National Cancer Institute (1959)

The forestomach of C57BL mice proved to be highly sensitive to the tumorigenic action of polycyclic carcinogens. A single application of 2 drops of 1.5 percent 7,12-dimethylbenz[a]anthracene (DMBA) to the skin of 47 C57BL mice was followed by the appearance of lymphomas in 11 mice and papillomas of the forestomach in 13. Among 33 control animals painted with benzene, only 1 died with a lymphoma, while no stomach tumors were found. A single intragastric application of 0.5 mg. of either DMBA or 3-methylcholanthrene (MC) gave rise to a forestomach tumor incidence of 85 percent and 57 percent, respectively. Multiple applications totaling 4 or 8 mg. of either DMBA or MC produced papillomas in all 44 treated animals and carcinomas in 6. Among 27 mice receiving 4 or 8 mg. of benz[a]anthracene (BA) by stomach tube, 2 developed papillomas of the forestomach after 16 months. No tumors appeared among 29 mice similarly treated once with 0.5 mg. of BA. The high sensitivity of the forestomach of the mouse suggests the use of this tissue for testing weakly carcinogenic compounds.
Evaluation of Effectiveness of Mixed Rotavirus Vaccine Course for Rotavirus Gastroenteritis
Authors: Daniel C. Payne, Iddrisu Sulemana, Umesh D. Parashar
Journal: JAMA Pediatrics (2016)

vere idiopathic ALTE is a rare condition.Larger studies are needed to assess the potential clinical implications of this novel, easily detectable, circulating marker, to understand the mechanisms and develop preventative strategies.
Operation for small-cell carcinoma revisited.
Authors: C F Mountain
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.5.687 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3033159 Operation for small-cell carcinoma revisited. C F MountainxC F MountainSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.5.687 PDF "Operation for small-cell carcinoma revisited.." Journal of Clinical Oncology, 5(5), pp. 687–688© 1987 by American Society of Clinical Oncology
AB0647 Veins Thrombosis Occuring in Takayasu Arteritis: Causal or Casual Relation?: Table 1.
Authors: H. Maamouri, T. Larbi, S. Hamzaoui, A. Elouni, K. Bouslama, S. M'rad
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Thromboembolic disease is an increasingly recognized complication of several vasculitides. Few cases of venous thrombosis were reported in the literature during Takayasu arteritis<sup>1,2</sup>. The possibility of venous disease was first described in 1968 by Sen<sup>3</sup>. <h3>Objectives</h3> The aim of this study was to evaluate the occurrence of venous thromboembolic events in Takayasu arteritis and discuss the possibility of either causal or casual association between these two conditions. <h3>Methods</h3> We retrospectively included 34 Takayasu arteritis patients according to the American College of Rheumatology Criteria<sup>4</sup> from 1983 to 2013. Among which, we studied cases who presented a venous thromboembolic event confirmed by image data. <h3>Results</h3> Three female patients suffering from Takayasu arteritis has presented a venous thrombosis. The table below illustrated the main epidemiological, clinical and imaging characteristics of these patients. <h3>Conclusions</h3> Venous thromboses in Takayasu9s disease are not well known. In the Takaysu disease there is an activation of platelets and the coagulation cascade which might be the cause of venous thrombosis. Furthermore it may also occur through an inflammation process which leads to stenoses. However, due to the smaller sample size, it should be noted that a direct cause-effect relationship cannot be established. <h3>References</h3> Bardi K, Bouziri S, Jaafoura H, Camillieri JP, Bennaceur M, Mzabi R. Venous involvement in Takayasu9s disease: does it exist? Ann Vasc Surg 1988;2:231-4. Ben Salah R, Frikha F, Kaddour N and al. Multiple deep vein thrombosis revealing Takayasu9s disease. J Mal Vasc 2013;38:60-1. Sen KB. Obstractive diseases of aorta and its branches. Ind J Surg 1986;30:289-329. Arend WP, Michel BA, Bloch DA, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 1990; 33: 1129–34. <h3>Disclosure of Interest</h3> None declared
The inherence heuristic: A key theoretical addition to understanding social stereotyping and prejudice
Authors: Rebecca S. Bigler, Caitlin Clark
Journal: Behavioral and Brain Sciences (2014)

Abstract Prior work has detailed the constructivist processes that lead individuals to categorize others along particular dimensions (e.g., gender) and generate the content (e.g., stereotypes) and affect (e.g., prejudices) associated with social groups. The inherence heuristic is a novel mechanism that appears to shape the content and rigidity of children's social stereotypes and prejudices.
Prognostic and Predictive Roles of Egfr Copy Number and Kras Mutation Status from the Radiant Trial of Adjuvant Erlotinib (E) Versus Placebo (P)
Authors: F.A. Shepherd, N.K. Altorki, W.E.E. Eberhardt, M.E.R. O'Brien, J. Wang, J.D. Horan, M.A. Foley, K.K. Iwata, S.C. Gill, F.C. Richardson, K. Kelly
Journal: Annals of Oncology (2014)
&lt;emph type="ital"&gt;Melting Snow&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal