tbuckley/cabot-search huggingface dataset:
Inspiration of psychotherapists by patients
Authors: E Messner
Journal: American Journal of Psychiatry (1976)

Many patients possess such exemplary traits and virtues that their psychotherapists are inspired to emulate them. This process can benefit the clinician and reinforce the therapeutic alliance, rapport, and the spirit of reciprocity; however, it can also arouse responses by the clinician that are therapeutically detrimental. Awareness of this hazard can enable the clinican to avert it and enhance the benefits provided by the patient's outstanding strengths.
Psychiatric comorbidity and length of stay in hospitalized AIDS patients
Authors: K K Uldall, L A Koutsky, D H Bradshaw, S G Hopkins, W Katon, W E Lafferty
Journal: American Journal of Psychiatry (1994)

The purpose of this study was to assess the effect of psychiatric comorbidity on specific measures of hospital utilization, including length of stay, among hospitalized AIDS patients.Data collection involved medical record abstraction for AIDS patients admitted to any one of 19 hospitals in Washington State during 1990. Psychiatric comorbidity was defined by the presence of an ICD-9 code reflecting psychiatric illness. Medical/surgical admissions of AIDS patients with psychiatric diagnoses were compared to those of AIDS patients without psychiatric diagnoses on measures of mean length of stay for the first admission in 1990, total number of hospitalizations in 1990, and total number of hospital days in 1990. Medical morbidity was addressed using CD4+ cell count and current and previous AIDS-defining illnesses as markers of disease severity.Of 357 patients hospitalized with AIDS, 49 (14%) had at least one psychiatric diagnosis. Patients with psychiatric illness were hospitalized an average of 6.6 days longer than AIDS patients without such illnesses. Differences in medical morbidity did not account for the longer length of stay.Psychiatric comorbidity increased the average length of stay among hospitalized AIDS patients. Future research needs to address the possible effects of this phenomenon on quality and cost of care received by AIDS patients.
Prognostic impact of deficient mismatch repair (dMMR) in 7,803 stage II/III colon cancer (CC) patients (pts): A pooled individual pt data analysis of 17 adjuvant trials in the ACCENT database.
Authors: Daniel J. Sargent, Qian Shi, Greg Yothers, Sabine Tejpar, Monica M. Bertagnolli, Stephen N. Thibodeau, Thierry Andre, Roberto Labianca, Steven Gallinger, Stanley R. Hamilton, Genevieve Monges, Katherine L. Pogue-Geile, Soonmyung Paik, Dirk Klingbiel, Arnaud Roth, Emily S Pavey, George P. Kim, Frank A. Sinicrope
Journal: Journal of Clinical Oncology (2014)

3507 Background: MMR status has been established as an important prognostic factor in CC pts. We determined the association of dMMR status with clinical/pathological features and prognosis using the ACCENT database. Methods: Microsatellite instability (MSI, 14 studies) or immunohistochemical analysis (1 study) for MLH1/MSH2/MLH6 proteins was performed on 7,803 stage II/III pts enrolled in 17 trials; 2 studies tested both. 571 pts received surgery alone; 3,878 5FU monotherapy (mrx); 2,299 5FU+oxaliplatin (oxal); and 1,055 5-FU+irinotecan (iri). Tumors with MSI-high or an absent protein were classified as dMMR; remainder were MMR-proficient (pMMR). Median follow-up was 7 years. Outcomes included overall survival (OS) and time to recurrence (TTR). Correlation analyses included all pts; prognostic analyses were limited to pts receiving surgery alone or 5FU mrx excluding pts receiving oxal/iri. Results: 524 (23.1%) of 2,270 stage II and 823 (14.9%) of 5,533 stage III pts exhibited dMMR. MMR status was associated with female sex (dMMR, 19% F v 16% M, p=0.004), higher T stage (dMMR, 11% T1/2 v 18% T3 v 21% T4, p < 0.001), and right-sided tumor location (dMMR, left 9% v right 27%, p < 0.001). Compared to pMMR, dMMR was strongly associated with improved OS (HR=0.27, p=0.01) and TTR (HR=0.27, p=0.01) in stage II pts treated with surgery alone (Table). Association of MMR was prognostic although of attenuated impact in 5FU treated stage II and in stage III pts , with significance confined to 5FU-mrx treated stage III pts (HR=0.80, p =0.02 for TTR; HR=0.79, p=0.02 for OS). Conclusions: Our study confirms prognostic utility of MMR status in stage II CCs. MMR also impacts outcome in stage III patients, but does not currently alter pt management. TTR OS 5-yr recurrence-free rate HR 95% CI p 5-yr survival rate HR 95% CI p Treatment dMMR pMMR dMMR pMMR Stage II Surgery alone (n=307) 89% 74% 0.27 0.10 -0.75 .012 90% 78% 0.27 0.10 - 0.74 .011 5FU-mrx (n=1155) 88% 83% 0.81 0.55 – 1.19 .285 88% 87% 0.87 0.61 – 1.26 .469 Stage III Surgery alone (n=264) 60% 47% 0.59 0.28 – 1.23 .162 59% 54% 0.69 0.35 – 1.36 .283 5FU-mrx (n=2723) 72% 64% 0.80 0.66 - 0.97 .025 77% 71% 0.79 0.65 - 0.97 .023
Brief hospitalization of patients with families: initial results
Authors: M I Herz, J Endicott, R L Spitzer
Journal: American Journal of Psychiatry (1975)

A total of 175 newly admitted inpatients who lived with families were randomly assigned to three treatment groups: standard inpatient care (discharge at the therapist's discretion), brief hospitalization (one week or less) with transitional day care available, and brief hospitalization without day care. Outpatient aftercare was offered to all patients. The three groups showed no significant differences as to amount of improvement in levels of psychopathology at 3 and 12 weeks, but the briefly hospitalized patients were able to resume their vocational roles sooner. There were no significant differences among the groups in readmission rates.
Psychiatric disorders in 36 families with Wolfram syndrome
Authors: R G Swift, D O Perkins, C L Chase, D B Sadler, M Swift
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to test the hypothesis that heterozygous carriers of the gene for the Wolfram syndrome, who constitute about 1% of the population, are predisposed to significant psychiatric illness. The Wolfram syndrome is an autosomal recessive neurodegenerative syndrome in which 25% of the individuals who are homozygous for the condition have severe psychiatric symptoms that lead to suicide attempts or psychiatric hospitalizations.The authors collected questionnaires, death certificates, and hospital records for blood relatives and their spouses in 36 families of individuals with the Wolfram syndrome and compared the proportion of blood relatives who had had psychiatric hospitalizations, had committed suicide, or had self-reported mental illness to the proportion of spouses with the same manifestations.The proportion of blood relatives who had had psychiatric hospitalizations, had committed suicide, or had self-reported mental illness significantly exceeded the proportion of spouses with the same manifestations.Since heterozygous carriers of the gene for the Wolfram syndrome are 50-fold more common among the blood relatives than among the spouses, the larger proportion among blood relatives is evidence that heterozygous carriers of the gene for the Wolfram syndrome are predisposed to significant psychiatric illness.
Depression Simulating Organic Brain Disease
Authors: Jesse O. Cavenar, Allan A. Maltbie, Linda Austin
Journal: American Journal of Psychiatry (1979)

The authors report four cases of depression manifesting as organic brain syndrome in adult nongeriatric patients. The correct diagnoses in three cases were made by a psychiatrist's or resident's empathic response to the patient, and in the fourth by the patient's history of depression. The authors state that only by maintaining a high degree of suspicion and trusting one's empathic response to the patient will unusual presentation of depression be recognized.
Fertility in patients on imatinib for chronic myeloid leukemia
Authors: M. K. Siddique, N. Siddiqui, R. Mahmood, H. Rehan
Journal: Journal of Clinical Oncology (2008)

18031 Background: Imatinib mesylate is now considered the standard first line treatment for newly diagnosed CML patients. Majority of CML patients in our population group are young, therefore fertility issues remain a major concern. This study was intended to observe effects of imatinib on fertility of these patients. Methods: Medical records of 200 adult CML patients who had been seen at our institution from 2004 to 2006 were evaluated retrospectively for conception and pregnancy outcome data. Patients who conceived were interviewed in detail about pregnancy and its outcome Results: 10 patients (7 males and 3 females) reported 13 conceptions. Seven healthy babies were born without congential defects. Three pregnancies were ended by elective abortion. Pregnancies conceived by 3 males are not born as yet. One female and two male patients conceived twice while taking imatinib. Conclusions: Although our patients on imatinib have successsfully conceived and delivered healthy babies, this preliminary data is not sufficient to change the current practice of strict contraception for patients on imatinib. Patients should also be informed of the risk of relapse if imatinib is stopped during pregnancy. Further studies are required to elucidate this important aspect of treatment for young CML patients. No significant financial relationships to disclose.
Fine-Tuning of CD8 + T Cell Mitochondrial Metabolism by the Respiratory Chain Repressor MCJ Dictates Protection to Influenza Virus
Authors: Devin P. Champagne, Ketki M. Hatle, Karen A. Fortner, Angelo D’Alessandro, Tina M. Thornton, Rui Yang, Daniel Torralba, Julen Tomás-Cortázar, Yong Woong Jun, Kyo Han Ahn, Kirk C. Hansen, Laura Haynes, Juan Anguita, Mercedes Rincon
Journal: Immunity (2016)
Special Report
Authors: Marion J. Finkel
Journal: New England Journal of Medicine (1982)

The Development of Orphan ProductsConsiderable attention has been directed in recent years to the plight of the patient with an uncommon disease for whom a drug or device with demonstrated or potential effectiveness remains unavailable because of a lack of commercial interest on the part of drug manufacturers. These products have become known as "orphans" not only because they are not distributed to physicians and their patients but also because additional studies required to obtain marketing approval for the products are not conducted, since little or no profit would be derived from their sale. Of additional concern is the . . .
Abstract P2-09-14: Surveillance program for women carrying BRCA1/BRCA2 genetic predisposition
Authors: T Sidoni, V Cocciolone, K Cannita, D Di Giacomo, A Ciccozzi, A Bafile, L Pizzorno, V Resta, C Marsecano, F Ferrari, E Di Cesare, C Ficorella, E Ricevuto
Journal: Cancer Research (2016)

Abstract Between January 2003 and January 2015, women at genetic risk of developing breast and/or ovarian cancer were selected for a surveillance program. The monitoring strategy consisted of the association of breast ultrasound (US), every six months, and Rx-mammography (XM) and breast MRI (MRI) to be performed annually. To date, 29 women have been included in the surveillance program: BRCA1 mutation carriers, 18; BRCA2 mutation carriers, 11. Eight women (28%) had already developed breast and/or ovarian cancer, while 21 (72%) were unaffected carriers. At a median surveillance time of 33 months (range 0-144), 4 incidental breast cancers were diagnosed in 4 BRCA1/2 mutation carriers (4/29, 14%), 2 BRCA1+ and 2 BRCA2+; 3/21 (14%) unaffected carriers and 1/8 (13%) previously affected carriers. Two cancers (50%) were detected by all three diagnostic tools; 2 (50%) were identified only by US and MRI in patients aging 33 and 43, respectively. Characteristics of patients with breast cancer diagnosed during surveillanceagemutated geneprevious cancerUSXMMRIhistologysurveillance time (months)33BRCA2-+-+ductal74+43BRCA2-+-+ductal40+45BRCA1-+++ductal60+40BRCA1yes+++ductal74+ One of these four patients, affected by breast cancer, died at 31 months of overall survival; three underwent surgery, chemotherapy and radiotherapy and are still disease free, in follow-up at 59, 28 and 26 months, respectively. In conclusion, 29 BRCA1/2 carriers have been included in the surveillance program, the median age was 42.5 months (range 27-68) and the median surveillance time was 33 months (range 0-144). Our preliminary data confirm the 3% expected rate of diagnosed cancers and the effectiveness of performing the triple diagnostic surveillance with US, XM and MRI. Citation Format: Sidoni T, Cocciolone V, Cannita K, Di Giacomo D, Ciccozzi A, Bafile A, Pizzorno L, Resta V, Marsecano C, Ferrari F, Di Cesare E, Ficorella C, Ricevuto E. Surveillance program for women carrying BRCA1/BRCA2 genetic predisposition. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-09-14.
Smoking, Smoking Cessation and Risk of Symptomatic Peripheral Artery Disease in Women: A Prospective Study
Authors: David Conen, Brendan M. Everett, Tobias Kurth, Mark A. Creager, Julie E. Buring, Paul M Ridker, Aruna D. Pradhan
Journal: Annals of Internal Medicine (2011)

Background
The detrimental effects of smoking on risk of myocardial infarction and stroke are well documented, but less information is available regarding peripheral artery disease (PAD), particularly among women.
Lithium ion transport by erythrocytes of randomly selected blood donors and manic-depressive patients: lack of association with affective illness
Authors: E Richelson, K Snyder, J Carlson, M Johnson, S Turner, A Lumry, E Boerwinkle, C F Sing
Journal: American Journal of Psychiatry (1986)

The authors measured the in vitro lithium ion ratio and maximal rate of sodium-lithium countertransport in erythrocytes of 739 randomly selected blood donors and 42 manic-depressive patients to determine the frequency distributions of these two variables in a general population and their relationship to one another and to affective illness. A large interindividual variation was found for the ratio and countertransport, and there was evidence of bimodality in the frequency distributions for these two traits. There was a moderate negative correlation (r = -.61) between the ratio and countertransport for 126 individuals. Neither the ratio nor countertransport was found to be a useful marker for affective illness.
Genetic contributions to human fatness: an adoption study
Authors: R A Price, R J Cadoret, A J Stunkard, E Troughton
Journal: American Journal of Psychiatry (1987)

A strong relationship was found between the degree of fatness of biologic mothers and that of their adult offspring who had been separated from their mothers at birth and adopted during the first year of life. This relationship persisted even after age, height, and possible confounding environmental factors were controlled. There was little evidence for either selective placement on the basis of parental fatness or gene-environment interaction. There was no relationship between the degree of fatness of adoptive parents and that of the adoptees. Two indexes of environmental influence--rural upbringing and disturbance in the adoptive home--predicted fatness among adoptees.
Spectrophotometric Determination of Dehydropeptidase Activity in Normal and Neoplastic Tissues
Authors: Charles E. Carter, Jesse P. Greenstein
Journal: JNCI Journal of the National Cancer Institute (1946)

Journal Article Spectrophotometric Determination of Dehydropeptidase Activity in Normal and Neoplastic Tissues Get access Charles E. Carter, Charles E. Carter assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 2, October 1946, Pages 51–56, https://doi.org/10.1093/jnci/7.2.51 Published: 01 October 1946 Article history Received: 20 August 1946 Published: 01 October 1946
Prognostic factors in metastatic carcinoma of unknown primary.
Authors: C L Loprinzi
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.3.514 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3819814 Prognostic factors in metastatic carcinoma of unknown primary. C L LoprinzixC L LoprinziSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.3.514 PDF "Prognostic factors in metastatic carcinoma of unknown primary.." Journal of Clinical Oncology, 5(3), pp. 514–515© 1987 by American Society of Clinical Oncology
Abiraterone acetate in metastatic castration-resistant prostate cancer after chemotherapy. A retrospective analysis of progression-free (PFS) and overall survival (OS) in the “Real Life”
Authors: M.A. Fabbri, M.A. Fabbri, D. Santini, E. Cortesi, T. Gamucci, P. Marchetti, F. Longo, F. Angelini, I. Sperduti, A. Milano, A. Pellegrino, F. Nelli, F. Primi, R. Raffaele, M.L. Mancini, S. Quadrini, A. Giuli, E.M. Ruggeri
Journal: Annals of Oncology (2015)
Abstract B38: A novel (+)-dehydroabietylamine derivative shows activity against triple-negative breast cancer cells
Authors: Lekh Nath Sharma Gautam, Taotao Ling, Fatima Rivas
Journal: Cancer Research (2016)

Abstract In both well developed and developing countries, breast cancer remains the leading cause of cancer-related death among women. Very few effective treatments are available to its subtype triple negative breast cancer (TNBC), being unresponsive to estrogen therapy. A phenotypic screening was performed on terrestrial natural products against the human breast carcinoma cell lines MDA-MB-231, MA11, and MCF-7 targeting new chemical scaffolds to TNBC. Further studies were focused on abietanes natural products that preferentially inhibited proliferation of triple-negative MDA-MB-231 cells over estrogen receptor–positive cells. The activity of the abietane carnosol prompted to generate a focus library from the readily available (+)-dehydroabietylamine. The lead compound (+)-pentafluoro sulfonamide derivative of dehydroabietylamine displayed a promising EC50 of 9.0 μM against MDA-MB-231 and our mechanistic studies indicate it induced apoptosis, which was associated with activation of caspase-9 and -3 and the cleavage of PARP. Current progress towards this promising therapeutic area will be discussed. Citation Format: Lekh Nath Sharma Gautam, Taotao Ling, Fatima Rivas. A novel (+)-dehydroabietylamine derivative shows activity against triple-negative breast cancer cells. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr B38.
Abstract P3-12-20: The impact of everolimus on radiation-induced pulmonary fibrosis in wistar albino rats: Results of an experimental study
Authors: MF Eren, A Ay Eren, B Yücel, S Elagöz, Y Özgüven, A Altun, S Kiliçkap, R Matsuno, N Bese
Journal: Cancer Research (2016)

Abstract Objectives: This study was performed to evaluate the effects of everolimus on pulmonary fibrosis, given concurrently or sequential with irradiation in rats. Materials and Methods: Forty female Wistar albino rats were randomized into five groups. The first group (Group 1: sham) was observed with identical conditions of the animals in other groups. The second group (Group 2) had only everolimus application. The third group (Group 3) had thoracic irradiation first and they had everolimus injection 22 hours after radiotherapy. The fourth group (Group 4) had irradiation to whole thoracic region in 2 hours of following everolimus administration. The last group (Group 5) had irradiation to whole thoracic region. As an end point the percentage of lung with fibrosis for each rat was quantified with image analysis of histological sections of the lung. Groups were compared using the linear regression method, Fisher's exact and chi-square tests were used to assess the association between treatment groups. Results: There was a statistically significant difference in the distribution of fibrosis scores among all groups (p=0.0022). Linear regression analyses revealed that all treatment groups showed an increased risk of lung fibrosis compared to control group. Group 2 (p=0.0020), group 3 (p&amp;lt;0.0001), group 4 (p&amp;lt;0.0001), and group 5 (p=0.0002). Chi-square test demonstrated that there was no statistically significant difference between the sequentially and concurrent treatment groups. Conclusion: This experimental study showed that of everolimus by itself may lead pulmonary fibrosis and addition to radiotherapy either sequentially or concomitantly increased the severity of the lung damage in rats. Keywords: Radiotherapy, everolimus, rats, pulmonary fibrosis. Citation Format: Eren MF, Ay Eren A, Yücel B, Elagöz S, Özgüven Y, Altun A, Kiliçkap S, Matsuno R, Bese N. The impact of everolimus on radiation-induced pulmonary fibrosis in wistar albino rats: Results of an experimental study. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-12-20.
High cholesterol levels in patients with panic disorder
Authors: W K Bajwa, G M Asnis, W C Sanderson, A Irfan, H M van Praag
Journal: American Journal of Psychiatry (1992)

This study was undertaken to help clarify whether the higher cholesterol levels found in patients with panic disorder are a complication of panic disorder only or are associated with any psychiatric disorder.The subjects of the study were 30 patients with panic disorder and 30 patients with major depression, diagnosed according to the Structured Interview for DSM-III-R, and 30 normal control subjects. The three groups were matched for sex and age, and none of the subjects had alcohol/drug abuse, abnormal ECGs, or unstable medical conditions. Blood samples were drawn at random times, and serum cholesterol levels were determined.The patients with panic disorder had significantly higher serum cholesterol levels than did the patients with major depression and the normal control subjects. Among the patients with major depression, histories (current or past) of anxiety disorders were associated with significant elevation of serum cholesterol levels. The presence of stable medical conditions was not associated with higher cholesterol levels in any of the three groups of subjects.Higher cholesterol levels were particularly associated with panic disorder in comparison with major depression. Higher levels of cholesterol in panic disorder are hypothesized to be a result of increased noradrenergic activity, which may be the underlying biological/neurochemical mechanism for symptoms of panic disorder, including anticipatory anxiety.