tbuckley/cabot-search huggingface dataset:
Predictive factors of response to neoadjuvant chemotherapy (NAT) in triple negative breast (TNBC) cancer patients: A restrospective multicenter observational study.
Authors: Teresa Gamucci, Lucia Mentuccia, Patrizia Vici, Laura Iezzi, Isabella Sperduti, Antonio Astone, Paolo Marchetti, Laura Pizzuti, Andrea Michelotti, Valentina Sini, Alessandra Cassano, Fabrizio Ciancola, Luca I. Moscetti, Silvia Quadrini, Elisabetta Landucci, Emanuela Magnolfi, Domenico Sergi, Clara Natoli
Journal: Journal of Clinical Oncology (2015)

e11542 Background: This is a multicenter observational study with the aim to evaluate predictive factors of response to NAT in TNBC pts. Methods: 196 TNBC pts treated with NAT were enrolled from 7 Italian cancer centres and retrospectively evaluated for % of pCR, ki67 pre and postNAT and treatment duration. Pts receiving NAT regimens were divided in 2 groups: longer (TAC and anthra-taxane sequences) and shorter (< 6 cycles) therapy duration and in 3 groups as a function of Ki67 levels (low (LL) ≤15 %, intermediate(IL) 15.1–35% and high(HL) >35%).OS and PFS were calculated by the Kaplan-Meier product-limit method. Log-rank and Tarone-Ware tests were used to assess differences between groups. A multivariate logistic regression model was developed using stepwise regression (forward selection) to compare the predictive power of different factors. Results: Pts' median age was 47 yrs (25-77), cT1-T2 62%and cT3-cT4 38%, 79% of pts had clinical axillary disease, 41% of pts received longer NAT and 59% shorter. PreNAT ki67 levels were: LL 20%, IL 12% and HL 68%. PostNAT Ki-67: LL 22%, IL 6%, and HL 42%, and 52 pts (26.5%) achieved pCR (95%CI 20-33). In the group of pts that received longer NAT, pCR was significantly more frequent compared to the group that received shorter NAT (38% vs 19% p = 0.005). Moreover pCR was more frequent in pts HL of Ki-67 (34%) compared to those with LL/IL (20%)(p = 0.05). In multivariate analysis HL of preNAT Ki-67 (OR 1.2 CI 95%1-1.3, p = 0.02) and longer duration of NAT response (OR 2.1 CI95% 1-4.3, p = 0.04) were significant predictive factors for. Conversely, cT and cN didn’t appear predictive. At a median follow-up of 42 months (2-190) overall PFS at 3yrs was 65% and 5yrs OS 76%. Pts with pCR had higher DFS and OS than pts with NopCR. DFS and OS gradually worsened with increasing postNAT Ki-67 level. Conclusions: Our analysis suggests that in TNBC treated with pre-NAT high ki67 levels and “adeguate” chemotherapy regimen are predictive factors of response and that post-NAT high ki67 levels and nopCR are negative predictors of survival. Data collection is ongoing and update results will be presented. DFS 3yrs (%) OS 5yrs (%) Ki67 HL >35% 56.3 62.2 pCR 92.9 92.9 No pCR 56.4 70.7
SP0234 Hip OA: Does it Require Specific Treatments
Authors: S. Bierma-Zeinstra
Journal: Annals of the Rheumatic Diseases (2015)

Although many guidelines for treatment of OA are released for hip and knee OA together, they emphasize that their recommendation mainly are based on research in knee OA because evidence for specifically hip OA is scarce. For the same reason other OA guidelines decided to separate their recommendations for treatment for hip and knee OA. For hip OA there only is evidence for symptomatic effectiveness of exercise, and of oral NSAIDs, while for other usual treatments the evidence is limited or absent based the number of studies. In addition to some differences in treatment effects between hip OA and knee OA, the difference in risk factors and OA phenotypes will be discussed during this session, as well as some diagnostic difficulties in hip OA. <h3>Disclosure of Interest</h3> None declared
J. W. Schereschewsky: An Appreciation
Authors: H. B. Andervont
Journal: JNCI Journal of the National Cancer Institute (1957)

J. W. Schereschewsky: An Appreciation Get access H. B. Andervont H. B. Andervont National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 2, August 1957, Pages 331–333, https://doi.org/10.1093/jnci/19.2.331 Published: 01 August 1957
Significance of Biopersistence in Relation to Pathogenic Effects in Humans: Environmental Asbestotic Pleural Plaques in Northeast Corsica: Correlations with Airborne and Pleural Mineralogic Analysis
Authors: F. Rey, C. Boutin, J. R. Viallat, J. Steinbauer, P. Alessandroni, P. Jutisz, D. Di Giambattista, M. A. Billon-Galland, P. Hereng, P. Dumortier, P. De Vuyst
Journal: Environmental Health Perspectives (1994)

We report a prevalence study of environmental pleural plaques in subjects over 50 years old from the northeastern Corsican village of Murato, built on asbestos surface deposits. The percentage of plaques was 41%, versus 7.5% in the control village of Vezzani. Although surface deposits contain both chrysotile and tremolite, airborne pollution and asbestos lung burden of exposed inhabitants consist essentially of tremolite as assessed by transmission electron microscopy (TEM). However, TEM analysis of the parietal pleura of three animals bred in exposed areas showed a predominance of short fibers of chrysotile. The respective roles of tremolite and chrysotile in inducing pleural plaques in Corsica should thus be considered.—Environ Health Perspect 102(Suppl 5):251–252 (1994)
Uterine Prolapse
Authors: Sarah Ringold
Journal: JAMA (2005)

Uterine ProlapseU terine prolapse is the protrusion of the uterus (womb) into the vagina, and at times outside the vagina, due to loss of support from the muscles and ligaments surrounding the uterus.Uterine prolapse is one form of pelvic organ prolapse.The bladder, rectum, or small bowel can also protrude into the vagina in related disorders.Uterine prolapse has been reported to occur in approximately 14% of women.Several factors may increase a woman' s risk of uterine prolapse, including her number of vaginal deliveries, delivery of a large infant, increasing age, and frequent heavy lifting.A number of conditions, including chronic obstructive lung disease, chronic constipation, and obesity, may also contribute to the development of uterine prolapse.The April 27, 2005, issue of JAMA includes an article that reviews the causes, diagnosis, and available treatments for uterine prolapse.
The Critic
Authors: Janet M. Torpy
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elimination of Mother-to-Child Transmission of HIV — Thailand
Authors: Rangsima Lolekha, Sarawut Boonsuk, Tanarak Plipat, Michael Martin, Chaweewan Tonputsa, Niramon Punsuwan, Thananda Naiwatanakul, Kulkanya Chokephaibulkit, Hansa Thaisri, Praphan Phanuphak, Suchada Chaivooth, Sumet Ongwandee, Benjamas Baipluthong, Wachira Pengjuntr, Sopon Mekton
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Thailand experienced a generalized human immunodeficiency virus (HIV) epidemic during the 1990s. HIV prevalence among pregnant women was 2.0% and the mother-to-child transmission (MTCT) rate was >20% (1-3). In June 2016, Thailand became the first country in Asia to validate the elimination of MTCT by meeting World Health Organization (WHO) targets. Because Thailand's experience implementing a successful prevention of MTCT program might be instructive for other countries, Thailand's prevention of MTCT interventions, outcomes, factors that contributed to success, and challenges that remain were reviewed. Thailand's national prevention of MTCT program has evolved with prevention science from national implementation of short course zidovudine (AZT) in 2000 to lifelong highly active antiretroviral therapy regardless of CD4 count (WHO option B+) in 2014 (1). By 2015, HIV prevalence among pregnant women had decreased to 0.6% and the MTCT rate to 1.9% (the elimination of MTCT target is <2% for nonbreastfeeding populations) (4). A strong public health infrastructure, committed political leadership, government funding, engagement of multiple partners, and a robust monitoring system allowed Thailand to achieve this important public health milestone.
CASE REPORT
Authors: RALPH B. LITTLE, MANUEL M. PEARSON
Journal: American Journal of Psychiatry (1954)

This paper presents a patient—the first, we believe—who, after cardiac surgery, successfully endured both insulin coma and electroconvulsive therapies. We feel that with the rapid increase in cardiac surgery and the resultant new way of living, other psychotic reactions may develop which will require shock therapies.
Ventricle-brain ratio and alogia in 19 young patients with chronic negative and positive schizophrenia
Authors: M Moscarelli, B M Cesana, S Ciussani, N C Novati, C L Cazzullo
Journal: American Journal of Psychiatry (1989)

In a group of 19 young patients with chronic mixed (both negative and positive) schizophrenia, the authors found that alogia was the only symptom to show a significant relationship to ventricle-brain ratio.
Withdrawal symptoms after long-term treatment with therapeutic doses of flurazepam: a case report
Authors: R M Berlin, L J Conell
Journal: American Journal of Psychiatry (1983)

A male patient with chronic insomnia experienced withdrawal symptoms when flurazepam (30 mg h.s.), which he had taken nightly for 8 years, was abruptly discontinued. Problems associated with sedative-hypnotic medication and the long-term treatment of chronic insomnia are discussed.
Cardiac Resynchronization Therapy for Heart Failure
Authors: Angelo Auricchio, Cecilia Fantoni
Journal: Annals of Internal Medicine (2004)

Cardiac resynchronization therapy (CRT) is a new therapeutic approach for a selected group of patients with symptomatic heart failure (NYHA functional class III-IV) despite optimal medical therapy, due to dilated cardiomyopathy of any etiology (left ventricular ejection fraction < or = 35% and left ventricular end-diastolic diameter > or = 55 mm), who present with electromechanical dyssynchrony (QRS > or = 130 ms). Safety and effectiveness of CRT have been demonstrated by several clinical trials, with patients achieving significant improvement in both clinical symptoms as well as functional status and exercise capacity. Furthermore, CRT has reduced morbidity of heart failure patients, while its impact in improving survival still remains to be clarified. Whether or not heart failure patients candidate to CRT should receive a defibrillator back-up remains debatable, although growing evidence is pointing to extensive use of a defibrillator in such a population.
Improvement of Parkinsonism in depressed patients treated with ECT
Authors: Z M Lebensohn, R B Jenkins
Journal: American Journal of Psychiatry (1975)

Two patients with severe Parkinson's disease were treated with electroconvulsive therapy for a supervening depression. Not only did the symptoms of depression clear up after only four treatments, but the parkinsonian signs also showed striking and sustained improvement. This may be related to ECT-induced changes in dopamine and norepinephrine metabolism. Parkinsonism does not appear to be a contraindication to ECT. On the contrary, ECT may be the treatment of choice for certain patients with Parkinson's disease, whether nor not it is complicated by intractable depression.
Dabrafenib plus trametinib in patients with previously untreated BRAFV600E-mutant metastatic non-small-cell lung cancer: an open-label, phase 2 trial
Authors: David Planchard, Egbert F Smit, Harry J M Groen, Julien Mazieres, Benjamin Besse, Åslaug Helland, Vanessa Giannone, Anthony M D'Amelio, Pingkuan Zhang, Bijoyesh Mookerjee, Bruce E Johnson
Journal: The Lancet Oncology (2017)
Hepatitis B and C surveillance and screening programmes in the non-EU/EEA Member States of the WHO European Region: survey findings from 10 countries, 2012
Authors: Antons Mozalevskis, Irina Eramova, Kelly Safreed-Harmon, Jeffrey V Lazarus
Journal: Eurosurveillance (2016)

The hepatitis B virus (HBV) and hepatitis C virus (HCV) epidemics warrant a comprehensive response based on reliable population-level information about transmission, disease progression and disease burden, with national surveillance systems playing a major role. In order to shed light on the status of surveillance in countries of the World Health Organization (WHO) European Region outside of the European Union and European Economic Area (EU/EEA), we surveyed 18 countries in Central and Eastern Europe. Among the 10 countries that responded, the common features of many surveillance systems included mandatory surveillance, passive case-finding and the reporting of both acute and chronic HBV and HCV. Only some countries had surveillance systems that incorporated the tracking of associated conditions and outcomes such as cirrhosis and liver transplantation. Screening programmes for some key populations appeared to be in place in many countries, but there may be gaps in relation to screening programmes for people who inject drugs, prisoners, sex workers and men who have sex with men. Nonetheless, important components of a surveillance structure are in place in the responding study countries. It is advisable to build on this structure to develop harmonised HBV and HCV surveillance for all 53 Member States of the WHO European Region following the example of the system recently instituted in EU/EEA countries.
Case 31-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Clarence T. Sasaki, Ben Z. Pilch
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 39-year-old woman was admitted to the Massachusetts Eye and Ear Infirmary because of stenosis of the subglottic area and pulmonary artery.She was well until six years earlier, when she received gunshot wounds to the abdomen and extremities, without cervical or thoracic injury, and was left with weakness of the left hand and a left footdrop. Three years before admission exertional dyspnea developed, soon followed by a nonproductive cough and exertional syncope. Thirty-four months before entry she underwent an operation to correct a nasal septal defect. A saddle-nose deformity and periodic epistaxes developed. Syncopal episodes continued, . . .
Platelet serotonin concentration in schizophrenic patients
Authors: T Kolakowska, S G Molyneux
Journal: American Journal of Psychiatry (1987)

Platelet serotonin (5-HT) concentration did not significantly differ between control subjects (N = 45) and schizophrenic (N = 62) or chronic schizophrenic (N = 39) patients. No clinical feature was associated with hyperserotonemia, but the subgroup receiving benzodiazepines had a significantly higher 5-HT level than other patients.
THE DIAGNOSIS OF PANCREATIC DISEASE
Authors: A RICHMAN
Journal: JAMA (1930)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTH-350 The effect of mucinous pathology on outcomes in rectal cancer
Authors: T Shamji, H Jones, D Harris
Journal: Gut (2015)

<h3>Introduction</h3> Mucinous adenocarcinoma (MA) is a specific morphological subtype of colorectal cancer (CRC). It is characterised when &gt;50% of the tumour is composed of extracellular mucin pools. This subtype represents 5–15% of CRC. There have been several studies demonstrating poor overall survival in mucinous CRC, in our study; we aim to assess the impact of mucinous pathology in rectal cancers. <h3>Method</h3> A total of 291 patients with rectal cancer were identified and studied between 2002–2013 in a tertiary colorectal centre (Swansea Colorectal Unit, Swansea, UK). A prospectively maintained central pathology database was used to identify patients with rectal cancer. The histopathological report was used to identify the tumour as either mucinous or non-mucinous (NMA). The primary outcome measures were disease free survival (DFS) and overall survival (OS) in patients that received surgery alone. <h3>Results</h3> There were 26 patients with MA and 265 NMA. There was no significant difference in median age and sex between both groups. The most common surgical procedure performed was an anterior resection in both groups (MA (58%) and NMA (65%). Poor differentiated tumours were found in 35 and 12% of MA and NMA, respectively (p = 0.001). There was no difference in DFS (p = 0.503) or OS (p = 0.478) in the 60 month follow-up period. <h3>Conclusion</h3> Our study did not demonstrate a significant difference in survival outcomes in patients with mucinous rectal cancer compared to NMA. However, the study did find a significant difference in tumour differentiation with MA associated with poor differentiated tumours. <h3>Disclosure of interest</h3> None Declared.
Reasons given for success after initial failure on the American Board of Psychiatry and Neurology Part II Examination
Authors: L H Rudy, M J Kulieke
Journal: American Journal of Psychiatry (1981)

In an attempt to help understand the Part II oral examinations of the American Board of Psychiatry and Neurology, the authors undertook a study to identify the factors that aid candidates in passing the Part II examination after one or more initial failures. A total of 339 diplomates rated 13 reasons hypothesized for passing Part II. The major factors that influenced passing on subsequent attempts were 1) the experience of having taken the examination previously (81%), 2) different examiners (66%), 3) decreased anxiety (61%), 4) additional studying (59%). Other factors suggested by diplomates for passing after initial failures included less fatigue and fewer personal problems.
A dopaminergic mechanism in mania
Authors: R H Gerner, R M Post, W E Bunney
Journal: American Journal of Psychiatry (1976)

The authors present a case study that explores the relationship of dopamine function and manic illness through the use of two drugs with relatively specific effects in stimulating and blocking dopamine receptors--piribedil (ET--495) and pimozide, respectively. Piribedil, as well as d-amphetamine, was associated with manic episodes, while pimozide had an antimanic effect. These observations suggest that dopaminergic mechanisms may be involved in the mediation of manic episodes in at least some patients.
Salmonella enteritidis and S. typhimurium in Western Europe for 1993-1995: a surveillance report from Salm-Net
Authors: I. S.T. Fisher
Journal: Eurosurveillance (1997)

Surveillance has been defined as the ongoing systematic collection, collation and analysis of data and the prompt dissemination of the resulting information to those who need to know so that an action can result. This is achieved in two ways. Firstly, i
First report of a Salmonella enterica serovar Weltevreden outbreak on Réunion Island, France, August 2007
Authors: E D'Ortenzio, F  X Weill, S Ragonneau, J A Lebon, P Renault, V Pierre
Journal: Eurosurveillance (2008)

An outbreak of gastroenteritis involving 26 guests of a wedding dinner occurred in August 2007 in Réunion Island, a French Overseas Department. Salmonella was isolated in 61.5% of cases and the two isolates serotyped were of serovar Weltevreden. We believe this to be the first food-borne outbreak due to S. enterica serovar Weltevreden described in Réunion Island. The epidemiological and environmental investigations of this outbreak did not provide enough evidence to identify a single vehicle of infection. It is necessary to improve surveillance of salmonellosis by multidisciplinary cooperation between clinicians, epidemiologists, microbiologists and veterinarians on Réunion Island.