tbuckley/cabot-search huggingface dataset:
How much cost can one patient bear? The influence of income and education on drug purchasing decisions in Hong Kong Chinese cancer patients
Authors: T. Chan, S. Chan, Y. Poon, J. Fok, J. Epstein, J. Mak, R. Epstein
Journal: Journal of Clinical Oncology (2007)

19584 Background: Inflation of anticancer drug prices is a growing problem worldwide. This problem is especially challenging in Asia, where rising healthcare expectations clash with low incomes and weak insurance. To clarify the factors influencing drug purchasing decisions in this context, we conducted a survey of Hong Kong oncology patients. Methods: A questionnaire was designed to assess the effect of cost on purchasing decisions relating to drug variables such as (1) efficacy, (2) tolerability, (3) convenience, (4) safety, (5) novelty and (6) reliability. Validation of the original 33-part survey resulted in a final set of 21 questions that was administered to 51 oncology patients. These respondents were characterised in terms of age, household income, insurance, educational level, family circumstances, occupation, ethnicity, religious beliefs, prognosis, and co-morbidity. Results: Most respondents were Hong Kong (68.8%), mainland Chinese (18.8%) or Caucasian (10.4%). There was a strong correlation between household income and education. Patients from middle-income (US$7,000–14,000 per month) households were most influenced in their decisions by costs and insurance rebates, whereas those from low-income households (less than US$3,000 per month) were keenest to purchase expensive medications, whether Western or traditional Chinese remedies. Demand for drug safety was cost-inelastic across all income groups, independent of gains in efficacy. Even when free treatment was offered, therapeutic uncertainties (e.g., early-phase drugs or randomization) proved unpopular with all income groups. Only the most affluent and well-educated patients valued overall survival above disease-free survival in making decisions, suggesting that less educated cohorts did not understand these concepts. Conclusion: These data suggest that low-income cancer patients and their families may have unrealistic expectations of high-priced medications, based either on misunderstanding or cultural pressures. Greater educational efforts targeting this large population sector may be needed to avoid worsening dissatisfaction and social unrest in the future. No significant financial relationships to disclose.
Expression of T Cell Co-Stimulator (ICOS) and Its Ligand and Disease Progression in B-Cell Chronic Lymphocytic Leukemia.
Authors: Tetsuya Fukuda, Donna S. Neuberg, Lang Huynh, Laura Z. Rassenti, Tracy L. Toy, Kanti R. Rai, Micheal J. Keating, John G. Gribben, Ian W. Flinn, John C. Byrd, Neil E. Kay, Thomas J. Kipps
Journal: Blood (2005)
A Small Molecule Inhibitor of the Gas6/Mer Pathway Inhibits Platelet Activation and Thrombosis with Equal Efficacy to, but Greater Potency Than, iMer, the Novel MerTK Splice Variant
Authors: Brian R. Branchford, Luke Law, Susan Sather, Gary Brodsky, H. Shelton Earp, Xiaodong Wang, Stephen Frye, Douglas K. Graham, Jorge A Di Paola
Journal: Blood (2012)
Use of Ubiquitin-Proteasome System Profiling for Differentiating Between Various Leukemic Processes.
Authors: Ke Zhang, Hagop M. Kantarjian, Wanlong Ma, XI Zhang, Xiuqiang Wang, Zeev Estrov, Chen-Hsiung Yeh, Anthony Sferruzza, Susan O'Brien, Michael Keating, Maher Albitar
Journal: Blood (2009)
OP0094 Physician and Patient Estimates of Global Status Are More Likely To Be Discordant in Osteoarthritis than in Rheumatoid Arthritis: Table 1.
Authors: I. Castrejon, J. Chua, J.A. Block, T. Pincus
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Concordance between global estimates of clinical status by physicians and patients may influence shared decisions concerning therapy toward better compliance and outcomes. However, discordance has been described in most rheumatology settings in which it has been studied carefully<sup>1,2</sup>. While osteoarthritis (OA) generally is regarded as a less severe medical problem than rheumatoid arthritis (RA), recent evidence suggests similar disease burdens in both OA and RA. <h3>Objectives</h3> To analyze discordance between physician global estimates (DOCGL) and patient global estimates (PATGL) in OA vs RA patients seen in a routine rheumatology academic setting. <h3>Methods</h3> In this setting, all patients complete a multidimensional health assessment questionnaire/routine assessment of patient index data (MDHAQ/RAPID3), which includes 0–10 scores for physical function, pain, and PATGL compiled into a 0–30 RAPID3, as well as fatigue VAS, a symptom checklist, and a RADAI self-report joint count, and demographic data. Patients with primary diagnoses of OA or RA were classified into 3 categories: PATGL≥DOCGL by 2/10 units, PATGL=DOCGL, and DOCGL≥PATGL by 2 units. The percentage of patients in each group was compared between RA and OA using chi-square. Variables were compared using ANOVA. <h3>Results</h3> The study included 216 patients with RA, 39 (18%) were discordant with PATGL&gt;DOCGL and 243 patients with OA, 82 (34%) were similarly discordant. Concordance with PATGL=DOCGL was seen in 144 patients (67%) with RA and 136 patients (56%) with OA, while discordance with DOCGL&gt;PATGL was seen in 33 patients (15%) of patients with RA and 25 (10%) with OA (p&lt;0.001). Age did not differ in the groups, other than older patients with OA (72.6 yrs) curiously were among the fewer OA patients who were more likely to show DOCGL&gt;PATGL than younger patients with OA (64.6–64.8 yrs). Patients with PATGL&gt;DOCGL had lower formal education levels (p&lt;0.05 in RA but not OA). Other MDHAQ measures were higher in OA patients than in RA patients with (Table). Highest MDHAQ scores were seen in patients with PATGL&gt;DOCGL than in PATGL=DOCGL than in DOCGL&gt;PATGL (p&lt;0.001 other than symptoms and RADAI). <h3>Conclusions</h3> Patients with OA are more likely to have their clinical status underestimated by rheumatologists than patients with RA, although the burden of disease in OA in these patients was greater than in RA. These data suggest a need to revise generally held views that OA is less severe than RA. <h3>References</h3> Arthritis Care Res (Hoboken) 2014;66:934–42. Arthritis Care Res (Hoboken) 2012;64:206–14. <h3>Disclosure of Interest</h3> I. Castrejon: None declared, J. Chua: None declared, J. Block: None declared, T. Pincus Shareholder of: Health Report Services, Inc
An In Vitro model of the Bone Marrow in Paroxysmal Nocturnal Hemoglobinuria Showing a Direct Effect of T-Cells within the Bone Marrow Allowing Clonal Expansion
Authors: Richard J Kelly, Stephen John Richards, Matthew Cullen, Louise M Arnold, Gemma L Brooksbank, Anita Hill, Reuben Tooze, Gina M Doody, Peter Hillmen
Journal: Blood (2011)
Low JAK2V617F Allele Burden in Primary Myelofibrosis, Compared to Either a Higher Allele Burden or Unmutated Status, Predicts Inferior Overall and Leukemia-Free Survival.
Authors: Ayalew Tefferi, Terra L. Lasho, Jocelin Huang, Christy Finke, Curtis A. Hanson, Ruben A. Mesa, Animesh Pardanani
Journal: Blood (2007)
FRI0438 Description and Prevalence of Spondyloarthritis in A Large Cohort of Patients with Anterior Uveitis: The Sentinel Interdisciplinary Collaborative Project
Authors: X. Juanola, E. Loza, M. Cordero-Coma
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> While the diagnosis of many SpA is usually made in rheumatology units based on other clinical findings as the inflammatory low back pain or arthritis (1,2), it has been described that there could be patients with AU with an undiagnosed SpA (3). Therefore, an early recognition of a possible SpA in patients attending the ophthalmology units with uveitis is vital in order to improve these patient9s management <h3>Objectives</h3> To describe and analyse the prevalence of spondyloarthritis (SpA) in patients with anterior uveitis (AU). <h3>Methods</h3> In a multicentric prospective study, consecutive patients with AU HLA-B27 positive or HLA-B27 negative with more than one episode of AU separated by at least 3 months were selected and evaluated by an ophthalmologist and a rheumatologist following a pre-defined visits schedule. Patients with previous diagnosis of SpA were excluded. Sociodemographic and clinical variables including the diagnosis of SpA according to ASAS criteria and an exhaustive ophtalmological examination were collected. Baseline descriptive, bivariate and concordance analyses were performed. <h3>Results</h3> We included 798 patients, most men (59%) with a mean age of 45 years, 60% with AU HLA-B27 positive, 40% with recurrent AU HLA-B27 negative. A total of 50.2% and 17.5% presented axial and peripheral SpA according to ASAS criteria respectively. Patients with AU and HLA-B27 were more frequently diagnosed of axial (69.8% vs 27.3%, p&lt;0.0001) and peripheral SpA (21.9% vs 11.1%, p&lt;0.0001) than patients with recurrent AU with HLA-B27 negative. In general, we did not detect important differences between groups in the ophthalmologic variables. <h3>Conclusions</h3> A high rate of patients with clinically significant AU have an undiagnosed SpA, higher if HLA-B27 was positive. <h3>References</h3> Rojas-Vargas M, Munoz-Gomariz E, Escudero A, Font P, Zarco P, Almodovar R, et al. First signs and symptoms of spondyloarthritis–data from an inception cohort with a disease course of two years or less (REGISPONSER-Early). Rheumatology (Oxford, England). 2009;48(4):404–9. Roussou E, Sultana S. Early spondyloarthritis in multiracial society: differences between gender, race, and disease subgroups with regard to first symptom at presentation, main problem that the disease is causing to patients, and employment status. Rheumatology international. 2012;32(6):1597–604. Monnet D, Breban M, Hudry C, Dougados M, Brezin AP. Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology. 2004;111(4):802–9. <h3>Disclosure of Interest</h3> None declared
Primary care referrals to surgery of patients with diabetes. A multicentre assessment of current practice in the east of England
Authors: E.S. Photi, A.N.R Barnett, C.P. Challand, N.A. Chatzizacharias, N.P. Dlamini, T. Doulias, A. Foley, J. Martin, I. Nunney, I. Panagiotopoulou, D. Pournaras, N. Sengupta, P. Sinclair, P. Stather, M.M. Than, A.C. Wells, K. Dhatariya
Journal: International Journal of Surgery (2016)
AB0439 Adverse Events after Surgery in Pediatric Patients with SLE: A Nationwide Study
Authors: C.-C. Liao, T.-L. Chen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Little was know about the outcomes after surgery in pediatric patients with systemic lupus erythematosus (SLE). <h3>Objectives</h3> Our purpose is to investigate the postoperative adverse events among surgical pediatric patients with preoperative SLE in a nationwide population-based study. <h3>Methods</h3> We used Taiwan9s National Health Insurance Research Database to identify pediatric inpatients with SLE and 258294 controls receiving major surgery. Sociodemographic characteristics, preoperative comorbidities, postoperative 30-day in-hospital major complications and mortality were analysed among surgical patients with and without SLE. <h3>Results</h3> Pediatric patients with SLE had a higher prevalence of preoperative coexisting medical conditions and postoperative major complications. The OR of 30-day postoperative mortality for surgical patients with SLE was 8.55 (95% CI 2.65–27.6) after adjustment. Among pediatric patients, SLE was associated with postoperative pneumonia (OR 8.79, 95% CI 5.54–13.9), acute renal failure (OR 30.6, 95% CI 14.8–63.2), admission to intensive care unit (OR 2.16, 95% CI 1.55–3.00), prolonged length of stay (OR 2.45, 95% CI 1.78–3.38) and increased medical expenditure (OR 2.64, 95% CI 1.92–3.63). <h3>Conclusions</h3> Among pediatric population, SLE significantly increased the risks of surgical complications and mortality after major surgery. Our findings demonstrated the need for integrated care and revised protocols for perioperative management to improve outcomes for pediatric patients with SLE. <h3>Disclosure of Interest</h3> None declared
Results of a Randomized Phase II Trial of Pegfilgrastim Versus Filgrastim To Treat Neutropenia Post-Autologous Peripheral Blood Stem Cell Transplant (PBSCT) in Patients with Non-Hodgkin’s Lymphoma (NHL).
Authors: Robert Rifkin, Roy Beveridge, Gary Spitzer, Gregory Orloff, Romeo Mandanas, Dean McGaughey, Mark Brunvand, Feng Zhan, Kristi A. Boehm, Lina Asmar
Journal: Blood (2007)
Dissection of the Role of Connexin-43 in Hematopoietic Progenitors and Stromal Cells Unveils Distinct Hematopoietic Intrinsic and Extrinsic Regulatory Functions.
Authors: Lina Li, Bhuvana Murali, Dealma N. Worsham, Susan K. Dunn, Jose A. Cancelas
Journal: Blood (2007)
Results of a Multi-Center, Phase II Study of Elsamitrucin (SPI-28090) in Patients with Relapsed or Refractory Non-Hodgkin’s Lymphoma (NHL).
Authors: Kenneth Foon, Steven Allen, Kaushik Sen, Ann Mohrbacher, Shamel Sanani, Luigi Lenaz, Rosamerlinda Rosales
Journal: Blood (2005)
Phlebotomy as an Effective Treatment for Iron Overload after Allogeneic Hematopoietic Cell Transplantation: Iron Depletion Kinetics Are Influenced by the Donor Hemochromatosis (HFE) Genotype.
Authors: Ann-Kathrin Eisfeld, Medical Student, Ralph Burkhardt, Sabine Schroeder, Rainer Krahl, Elvira Edel, Christa Doering, Dietger Niederwieser, Haifa K. Al-Ali
Journal: Blood (2005)
Supervised physiotherapy for mild or moderate ankle sprain
Authors: Chris Bleakley
Journal: BMJ (2016)

Lateral ankle sprains are the most common musculoskeletal injuries in physically active populations.1 Incidence rates in the general population are also high, at an estimated five to seven injuries per 1000 people per year.2 3 More than 40% of patients fail to recover because of persistent pain, recurrent injury, and instability.4 These symptoms, which are characteristic of chronic ankle instability, result in long term constraints to levels of physical activity and could be a key mediator for post-traumatic osteoarthritis.4 Despite this, many patients regard ankle sprains as being innocuous with fewer than half seeking formal medical care.5 This generally occurs in an emergency care facility and is based on advice for self management. While supervised rehabilitation represents a more comprehensive approach, there is ongoing controversy around its cost benefit ratio.
High Dose Glucocorticoids Potentiate the Reponse to Erythropoietin.
Authors: Maged Khalil, Zili He, Ashish Sangal, Aref Agheli, Alka Arora, Theresa Dumlao, Seema Naik, Elizabeth Chiu, Madhumati Kalavar, William Steier
Journal: Blood (2006)
PWE-156 What is The Prevalence of Chronic Pancreatitis at Post Mortem? A Novel Approach Using “Digital Autopsy”
Authors: JA Campbell, DS Sanders, C Howard, J Hampton, AD Hopper
Journal: Gut (2016)

<h3>Introduction</h3> The prevalence of exocrine insufficiency in patients with IBS type symptoms does not correlate with post mortem prevalence of chronic pancreatitis (CP) suggesting a failure of early diagnosis. Historical dissection post mortem studies estimate the incidence of chronic pancreatitis to be around 6–12%. “Digital autopsy” computerised tomography (CT) is a non-invasive alternative to conventional post mortem examination. We aimed to evaluate the prevalence of radiological changes of CP with this technique. <h3>Methods</h3> Consecutive non-contrast post mortem CT scans were reviewed. Simple demographic information was collected (sex, age at death) as well as interval between death and scan. The presence of pancreatic calcification and/or atrophy was noted as radiological indicators of chronic pancreatitis. Main pancreatic duct anatomy was reviewed but smaller ductal changes were not assessed due to lack of intravenous contrast. <h3>Results</h3> 124 scans were included for assessment (mean age 67.6 years, SD 18.6, 63.8% male). 9 scans were excluded due to inadequate pancreatic views (6 due to decomposition, 3 due to intra-abdominal fluid, lymphadenopathy or artefact). Scans were performed 0–14 days post mortem (median 2 days). 36/115 (32.1%) of those scanned had features of chronic pancreatitis. 20/115 (17.9%) had calcification, 26 (23.2%) had atrophy and 2 (1.8%) main pancreatic duct dilatation. There is a significant difference between average ages of those with (78 years) and without (62 years) radiological evidence of chronic pancreatitis (p &lt; 0.0001) <h3>Conclusion</h3> This is the first study to report the prevalence of chronic pancreatitis using post mortem CT. The prevalence seems to be higher when compared to conventional autopsy reporting. This could suggest an under diagnosis of early CP in clinical practice. <h3>Disclosure of Interest</h3> None Declared
THU0078 Moderate Alcohol Consumption Is Not Associated with Serum Liver Abnormalities in Patients with Rheumatoid Arthritis Taking Methotrexate: Data from The Clinical Practice Research Database (CPRD):
Authors: J.H. Humphreys, A. Warner, S. Verstappen, M. Lunt, W. Dixon
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Methotrexate (MTX) is the most commonly prescribed disease modifying anti-rheumatic drug in the treatment of rheumatoid arthritis (RA). Patients taking MTX are advised to restrict their alcohol consumption because of a theoretical hepatotoxic interaction between alcohol and MTX. However data are limited to support this advice. <h3>Objectives</h3> To quantify the association between alcohol consumption and abnormal serum liver function tests (LFTs) in patients with RA taking MTX, using routinely collected clinical data. <h3>Methods</h3> Patients with RA in the Clinical Practice Research Database (CPRD) starting MTX between 1987 and 2011 were studied. Patients were included if they had alcohol consumption details recorded in CPRD and ≥6 LFTs per year, indicating adequate monitoring. Patients were grouped by reported weekly alcohol consumption. Crude rates of abnormal LFTs (defined as alanine transaminase or aspartate aminotransferase level ≥3 times the upper limit of normal) per 1000 person-years follow up were calculated. Cox proportional hazards models described the association between alcohol consumed and development of abnormal LFTs whilst taking MTX univariately, then adjusting for age and gender. Patients were censored at time of first abnormal LFT, death or the end of follow up (31/12/2011). <h3>Results</h3> 8801 patients were included in the study, 6285 (71%) female, mean age (SD) was 58 (14) years. There were 241 abnormal LFTs in 38000 person-years follow up. There was no difference in rates of abnormal LFTs between drinkers and non-drinkers, adjusted hazard ratio (HR) (95% confidence interval (CI)) 1.12 (0.82–1.51). Crude rates of abnormal LFTs appeared to increase with increasing levels alcohol consumption (table 1); similarly when treated as a continuous variable, each increased unit of alcohol consumed was associated with a higher risk of abnormal LFTs, adjusted HR (95%CI) 1.01 (1.00–1.02). In the adjusted Cox model, moderate alcohol consumption (≤14 units per week) was not associated with a statistically significant risk of developing abnormal LFTs (table 1). There was a non-significant trend to higher HR with higher levels of alcohol consumption, however power was limited in the patients consuming &gt;14 units per week. <h3>Conclusions</h3> In patients with RA taking MTX, increasing alcohol consumption is associated with an increased risk of developing abnormal LFTs. The clinical importance of this increased risk may be small when drinking ≤14 units per week. <h3>Disclosure of Interest</h3> None declared
AB0835 Reactive Arthritis: Diagnostic Difficulties and Causes of Misdiagnosis
Authors: J. Harisov, E. Djuraeva, A. Hon
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Timely diagnostics of inflammatory rheumatic diseases, particularly of Reactive Arthritis (ReA), and the development of reasonable management methods for their course are of a high importance in practice rheumatology, which are needed for early ethiotropic and pathogenetic treatment. <h3>Objectives</h3> Study course features of the urogenital ReA and causes of its misdiagnosis. <h3>Methods</h3> We have conducted 86 patients being admitted to the rheumatologic department of the 1st Clinic of Tashkent Medical Academy with directional diagnosis of ReA. 86 patients were divided into 48 men and 38 women aged 19 to 49 years old, with the disease duration of 1 month to 5 years. Acute course was observed in 17 patients, subacute course in 44, and chronic course of the disease in 25 patients. Disease progression after urogenital infection of the urinary tract was established in 58 cases, enterocolitic form in 18 cases, mixed form of ReA in 10 cases. To detect the urogenital chlamydial infection, we used a method of the indirect immunofluorescence of urethral or endocervical smear, and method of DNA diagnostics, when necessary. Patients with enterocolitic form of ReA were conducted with bacteriological stool test. <h3>Results</h3> The classic disease presentation, including arthritis, eyes and genital tract impairment was established in 47 of 58 cases. Among them, all 14 patients suffered from acute, 30 of 33 from subacute, 11 of 14 from chronic form of ReA. As to the misdiagnoses at onset of the disease, 1 patient was diagnosed with gout, 3 with rheumatoid arthritis, and 1 patient over 35 years old was diagnosed with osteoarthritis. All patients had involvement of the lower limbs joints in the pathological process. The oligoarthritis prevailed in acute and sub-acute ReA (80% and 92.8% of cases respectively). Monoarthritis was observed only in 20% cases with acute form of the disease. In the chronic disease course, polyarthritis prevailed with symmetric and asymmetric forms, which were observed in 62.8%; and the oligoarthritis in 37.2% cases. All patients during hospitalization or in history mentioned eyes impairment, which, according to our observations, was course independent. <h3>Conclusions</h3> Thus, timely diagnosis and adequate management requires distinctive knowledge of ReA clinical presentation and taking into account the course of the disease, and use of existing diagnostic criteria. Difficult diagnostic situations should be extended with case follow-up. <h3>Disclosure of Interest</h3> None declared
Association of Mannose Binding Lectin (MBL-2) Deficiency with Pulmonary Infection after Allogeneic Hematopoietic Stem Cell Transplantation (HSCT).
Authors: Dick Chung, Lily Ding, Isabelle Amigues, Katuna Kadeishvili, Theresa Lo, Eric Pamer, Stacey Kalambakas, Aby Buchbinder, Genovefa Papanicolaou
Journal: Blood (2008)