tbuckley/cabot-search huggingface dataset:
Secondary Myelodysplasia and Acute Leukemia Following Carboplatin-Containing Combination Chemotherapy for Ovarian Cancer
Authors: G. Colon-Otero, G. D. Malkasian, J. H. Edmonson
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Secondary Myelodysplasia and Acute Leukemia Following Carboplatin-Containing Combination Chemotherapy for Ovarian Cancer Get access Gerardo Colon-Otero, Gerardo Colon-Otero Section of Hematology and Oncology, Mayo Clinic JacksonvilleJacksonville, Fla. Correspondence to : Gerardo Colon-Otero, M.D., Section of Hematology/Oncology, Mayo Clinic Jacksonville, 4500 San Pablo Rd., Jacksonville, FL 32224. Search for other works by this author on: Oxford Academic PubMed Google Scholar George D. Malkasian, George D. Malkasian Division of Gynecologic Oncology, Mayo Clinic Rochester, Mayo Comprehensive Cancer CenterRochester, Minn. Search for other works by this author on: Oxford Academic PubMed Google Scholar John H. Edmonson John H. Edmonson Division of Medical Oncology, Mayo Clinic Rochester, Mayo Comprehensive Cancer CenterRochester, Minn. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 22, 17 November 1993, Pages 1858–1860, https://doi.org/10.1093/jnci/85.22.1858 Published: 17 November 1993 Article history Received: 30 March 1993 Revision received: 03 August 1993 Accepted: 12 August 1993 Published: 17 November 1993
Peptide Receptor Radionuclide Therapy With 177Lu DOTATATE in a Case of Recurrent Carotid Body Paraganglioma With Spinal Metastases
Authors: Santosh Kumar Gupta, Suhas Singla, Sellam Karunanithi, Nishikant Damle, Chandrasekhar Bal
Journal: Clinical Nuclear Medicine (2013)

Paragangliomas are rare benign neuroendocrine tumors, and 80% of all paragangliomas are either carotid body tumors or glomus jugulare tumors. We present a case of recurrent unresectable carotid body paraganglioma with nodal and T7 vertebral metastases in a 30-year-old man 6 years postsurgery detected with Ga DOTANOC PET/CT and was administered with peptide receptor radionuclide therapy using Lu DOTATATE. After 5 cycles of Lu DOTATATE (total cumulative activity of 750 mCi [27 GBq]), significant response at the primary site on Ga DOTANOC PET/CT and complete disappearance of nodal and T7 vertebral metastases were noted.
AB0866 Sensorineural hearing loss in patients with ankylosing spondyitis: Is it an extra-articular feature of disease?
Authors: A. Barcelos, R. Aguiar, I. Cunha, C. Ambrόsio, A. Neves, L. Azevedo
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ankylosing Spondylitis (AS) is a chronic inflammatory disease of unknown aetiology. Sacroiliitis is the hallmark of AS, but peripheral joints and extra-articular structures may also be affected. There are two points of otological interest in AS patients: the possibility of sensorineural hearing loss (SNHL) due to long-term use of non-steroidal anti-inflammatory drugs and the disease may affect articular tissue in the middle ear and vascular structures owing to autoimmune reactions in the inner ear. <h3>Objectives</h3> The aim of this investigation was to study the relationship between AS and hearing loss. <h3>Methods</h3> This study compared 61 patients with AS (122 ears) with 46 age-matched controlls (92 ears). All subjects underwent to an audiologic evaluation that included puré-tone audiometry thresholds at octave frequencies of 250 to 8000Hz and impedance audiometry (tympanogram and static compliance). <h3>Results</h3> The mean age of the patients was 45,85 years (range 20-75 years) and in the controls group was 41,48 years (range 25-55 years). Sensorineural hearing loss was found in 45 patients (73,7%) that was bilateral in 31 patients and unilateral in eleven patients. There was no statistically significant difference between the two groups with respect to hearing levels at 250 -500Hz and 4000-8000Hz (p=0,34). In AS group there was no correlation found between SNHL and age (p=0,16). There was also no correlation found between SNHL and limitation in neck movement. (p=0,17). <h3>Conclusions</h3> Sensorineural hearing loss is common in AS patients as well in controls in this study. In opposite of what is described in literature, in our study SHNL was found as frequently in AS patients as in controls. <h3>Disclosure of Interest</h3> None Declared
Concordance for Hodgkin's Disease in Identical Twins Suggesting Genetic Susceptibility to the Young-Adult Form of the Disease
Authors: Thomas M. Mack, Wendy Cozen, Darryl K. Shibata, Lawrence M. Weiss, Bharat N. Nathwani, Antonio M. Hernandez, Clive R. Taylor, Ann S. Hamilton, Dennis M. Deapen, Edward B. Rappaport
Journal: New England Journal of Medicine (1995)

Relatives of young adults with Hodgkin's disease are at increased risk of Hodgkin's disease, and lines of evidence implicate both inheritance and environment.
Magnifying narrow-band imaging endoscopy for the diagnosis of gastric primary extramedullary plasmacytoma: a first case report
Authors: Satoshi Harada, Shinya Fukunishi, Toshihisa Takeuchi, Kazuhiro Ota, Sugi Kazunori, Makoto Sanomura, Kazuh de Higuchi
Journal: Endoscopy (2014)

Magnifying narrow-band imaging (NBI) endoscopy has been increasingly used in the diagnosis of early gastric cancer and is regarded as an effective diagnostic approach. This technique has been used to classify gastric cancer according to the tumor surface structure and microvessels [1] [2]. We obtained a magnified NBI image that clearly showed the characteristics of gastric primary extramedullary plasmacytoma [3] [4], and treated it successfully using endoscopic submucosal dissection (ESD).
Abstract 2078: Deregulation of miR-92a expression is implicated in hepatocellular carcinoma development
Authors: Masami Tanaka, Akihiko Tsuchida, Masatoshi Shigoka, Tetsuya Aoki, Tomoki Takashina, Masakatsu Takanashi, Yoshiki Murakami, Masahiko Kuroda
Journal: Cancer Research (2010)

Abstract MicroRNAs (miRNAs) belong to a class of the endogenously expressed non-coding small RNAs which primarily function as gene regulators. Growing evidence suggests that microRNAs have a significant role in tumor development and may constitute robust biomarkers for cancer diagnosis and prognosis. Especially, the miR-17-92 cluster is markedly overexpressed in several cancers, and is associated with the cancer development and progression. In this study, we have demonstrated that miR-92a is highly expressed in hepatocellular carcinoma (HCC). In addition, the proliferation of a HCC cell line HepG2 was inhibited by the anti-miR-92a antagomir. On the other hand, we have found that the relative amount of miR-92a in the plasmas from HCC patients is decreased compared with that from the healthy donors. Interestingly, the amount of miR-92a was elevated after surgical treatment. Thus, although the physiological significance of the decrease of miR-92a in plasma is still unknown, deregulation of miR-92 expression in cells and plasma should be implicated in the development of HCC. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2078.
P628Relationship between endothelin-1, intercellular adhesion molecules-1 and lipoproteins in acute myocardial infarction
Authors: M O Harbar, HV Svitlyk, YO Svitlyk, OM Svitlyk, GV Tshngryan
Journal: Cardiovascular Research (2014)

Endothelin-1 (E-1) is the most informative marker of inflammation of the vessel wall. It causes the expression of adhesion molecules that stimulate the migration of leukocytes to the subendothelium. Ratio apoB/apoA1 reflects balance of cholesterol transport. Increased apoB/apoA1 indicates the deposition of cholesterol in the vessel wall and the progression of atherosclerosis.
Gastrointestinal Activity After Bone Marrow Scintigraphy
Authors: BRITA ÅGREN, KLAS MÅRE
Journal: Clinical Nuclear Medicine (1996)

Abdominal activity was seen on Tc-99m bone marrow imaging of multiple myeloma patients. The intensity varled from low in diffuse areas to high in well delineated areas when nanocolloid was used as a tracer. The activity was considered to be localized to the gastrointestinal tract presumably because of the by-products created during the radiopharmaceutical's degradation.
COMPARISON OF CHRONIC ANGIOSCOPIC FINDINGS OF BMS, 1ST-GENERATION DES AND 2ND-GENERATION DES: A REPORT FROM JAPANESE MULTICENTER REGISTRY (MICASA)
Authors: Kazuoki Dai, Hiroshi Matsuoka, Hideo Kawakami, Tetsuya Sato, Koki Watanabe, Yasuharu Nakama, Masaharu Ishihara
Journal: Journal of the American College of Cardiology (2016)
Abstract 2783: A novel functional variant is associated with regulation of the prostate stem cell antigen (PSCA) gene and bladder cancer risk in males
Authors: Yi-Ping Fu, Indu Kohaar, Brian Muchmore, Adam Mumy, Wei Tang, Patricia Porter-Gill, Montserrat Garcia-Closas, Stephen Chanock, Jonine Figueroa, Dalsu Baris, Mark Purdue, Michael Thun, Demetrius Albanes, Nuria Malats, Francisco X. Real, Manolis Kogevinas, Alison Johnson, Molly Schwenn, Nathaniel Rothman, Debra Silverman, Ludmila Prokunina-Olsson
Journal: Cancer Research (2011)

Abstract Genome-wide association studies (GWAS) identified allele T of SNP rs2294008 within the prostate stem cell antigen (PSCA) gene as a risk factor for diffuse gastric cancer (OR=1.67, p=2.2×10-15) (The Study Group of Millennium Genome Project for Cancer, Nat Genet, 2008) and bladder cancer (OR=1.13, p=4.4×10-11) (Rothman et al, Nat Genet, 2010). In the present study we used data from the Stage 1 bladder cancer GWAS, which was performed on 8,801 individuals of European ancestry (3,529 cases and 5,115 controls), and information from the 1000 Genomes and HapMap 3 projects to impute all other SNPs within +/- 50kb region surrounding PSCA. Association analysis on the combined set of all genotyped and imputed SNPs (n=375) revealed a novel bladder cancer association signal for a variant genotyped in all samples. The association was found only in males (n=7,359, crude OR =1.14, p=1.15×10-4; adjusted for all covariates and rs2294008, OR=1.13, p=1.32×10-3), while no association was observed in females (n=1,442, crude OR=0.98, p=0.81; adjusted for all covariates and rs2294008, OR=0.98, p=0.82). The low linkage disequilibrium between these two SNPs (D’=0.202 and r2=0.019 in 8801 GWAS samples) suggests these variants are independent. A joint analysis showed that these two SNPs have a compound association with bladder cancer dependent on the number of risk genotypes (0, 1 or 2) in males (adjOR=1.18, p=3.93×10-6) but not in females (adjOR=1.01, p=0.95). The risk allele T of rs2294008 is functional as it introduces a novel translation start site that creates a PSCA protein with a leader peptide extended by 11 amino acids. The novel SNP that was found 10 Kb upstream of rs2294008, lies within an alternative untranslated first exon of PSCA that is marked by a H3K4me3 signal and is in a vicinity of an androgen receptor binding site, suggesting a possible role for this variant in regulation of PSCA promoter activity. In conclusion, a novel independent functional variant associated with bladder cancer risk was found within the PSCA gene, which might be important for male-specific regulation of PSCA expression and carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2783. doi:10.1158/1538-7445.AM2011-2783
OC-090 Correlation between Distribution of HLA Haplotypes and Severity of Mucosal Damages
Authors: M Rostami Nejad, K Rostami, J Romanos, H Zojaji, M R Zali, C Wijmenga
Journal: Gut (2013)

<h3>Introduction</h3> Celiac disease is a chronic intestinal inflammation resulting in different degree of intestinal mucosal damages. The disease occurs in genetically predisposed individuals and associated with human leukocyte antigen (HLA)-DQ2/8 heterodimers. The aim of this study is to evaluate the correlation between distribution of HLA haplotypes and the severity of mucosal damages. <h3>Methods</h3> Fifty nineIranian celiac disease patients were evaluated to predict the HLA-DQA1 and -DQB1 genes, using tagging SNPs method. All patients had positive tTGA and/or EMA antibodies and histology according to Modified Marsh classification (Marsh I-IIIc) by Rostami <i>et al</i> <h3>Results</h3> The result of this study show that 86.4% of cases were carriers of HLA-DQ2 and/or HLA-DQ8 heterodimers, either homozygous or heterozygous. Marsh IIIa lesions were seen in 20 cases, Marsh IIIb in 9 and Marsh IIIc in 12 cases. Marsh IIIa is associated with HLA-DQ2 haplotype in 10 cases, IIIb with 4 and IIIc with 10 cases respectively. Marsh IIIa is correlated with HLA-DQ2.5/2.5 in 4 cases followed by HLA-DQ2.5/DQ8 and HLA-DQ2.5/DQX each in 3 cases respectively. <h3>Conclusion</h3> According to high prevalence of HLA-DQ2 haplotype in Iranian population, we can conclude that there is a strong link between severity of mucosal damages and presence of HLA-DQ 2 haplotype. Celiac disease cases with Marsh III (a-c) carry more HLA risk alleles compared to those with Marsh I-II and this difference were statistically significant for DQ2.5 haplotype distribution (P = 0.0001). <h3>Disclosure of Interest</h3> None Declared
Abstract 5001: Cachexia induced different tumor microenvironment.
Authors: Tatsuzo Matsuyama
Journal: Cancer Research (2013)

Abstract Back ground and aim Cancer cachexia affects up to 80% of patients with advanced cancers and accounts for nearly 30% of cancer-related deaths.Cachexia is pointed out of loss of fat mass, wasting of skeletal muscle, and cardiac atrophy. The mechanism by which the degree of cachexia is induced by the different local cancer environment has not been studied. In this study, we investigated the mechanism of cachexia in the different local tcarcinoma such as between subcutaneous tumor model and intraperitoneal tumor model. Materials and Methods Cachexia was induced by subcutaneous grafting and intraperitoneal administration using colon cancer cells, (colon 26cells 1 × 10 ˆ 6/ 100μL each) in7-week-old BALB/c mice. Two weeks after the tumor-bearing, we measured adipose tissue (around epididymis), gastrocnemius muscle, heart, and cytokines in serum. Result The body weight, heart, fat, muscle weight of each mice was decreased gradually as of significant difference in subcutaneous tumor model, and intraperitoneal tumor model compared with normal mice . We have a significant difference in IL-1a, IL-4, IL-6, IL-9, IL-10, IL-12 (p40), IL-12 (p70), IL-13, G-CSF, IFN-γ, KC, MCP-1, MIP I-1a in the serum cytokine of tumor models compared with normal models. IL-12(p40), IL-13, G-CSF, KC has significant differences in subcutaneous tumor model compared with intraperitoneal tumor model. Conclusion In addition to the skeletal muscle and fat, in the state of cachexia it has caused in smooth muscle. And these change of cachexia is induced by not only one cytokine but several cytokines. Other important result is that cachexia is induced different degree by tumor origin. Citation Format: Tatsuzo Matsuyama. Cachexia induced different tumor microenvironment. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5001. doi:10.1158/1538-7445.AM2013-5001
Efficacité de la dissection sous-muqueuse endoscopique pour le traitement des tumeurs colorectales superficielles résiduelles ou récidivantes après mucosectomie première: une expérience Japonaise
Authors: G Rahmi, S Tanaka, T Ishida, Y Morita, Y Ohara, T Yoshizaki, T Toyonaga, T Azuma
Journal: Endoscopy (2014)

La dissection sous-muqueuse endoscopique (ESD) permet la résection en bloc des tumeurs colorectales superficielles. L'objectif de l'étude était d'évaluer l'efficacité de l'ESD pour le traitement des tumeurs colorectales superficielles résiduelles après mucosectomie première, et de rechercher des facteurs prédictifs de la difficulté de la procédure.
EMF working group.
Authors: G A Boorman
Journal: Environmental Health Perspectives (1998)

However, a weight-of-evidence approach can only work if there is fill disclosure of industry- generated unpublished studies.In order to obtain scientific consensus on such matters, we propose that technical reviews of unpublished industry data be carried out by scientists and other technical experts working under the aegis of institutions such as the National Academy of Sciences, the Health Effects Institute, or other similar independent organi- zations.We would welcome the creation of such institutional arrangements to make it possible for exposure and health risk assessments to be conducted on a complete scientif- ic knowledge base.
ENDOSCOPIA INTRAOPERATORIA DURANTE LA RESECCIÓN POR LAPAROSCOPIA DE LESIONES SUBEPITELIALES GÁSTRICAS: ES SIEMPRE NECESARIA?
Authors: J Sampson, I Araujo, C Sánchez, D Momblán, H Córdova, À Ginès, AM Lacy, G Fernández-Esparrach
Journal: Endoscopy (2014)

Introducción: La resección laparoscópica es considerada el tratamiento de elección para los tumores subepiteliales gástricos. Ocasionalmente es necesario realizar una gastroscopia intraoperatoria para localizar la lesión. No existen estudios publicados sobre los factores que puedan predecir la necesidad de un abordaje combinado laparoscópico-endoscópico.
1359 PREDICTIVE CRITERIA OF EARLY MORTALITY AT ONE (M1) AND TWO MONTHS (M2) IN PATIENTS WITH SEVERE ACUTE ALCOHOLIC HEPATITIS (AAH) TREATED WITH CORTICOSTEROIDS
Authors: G. Macaigne, P. Lahmek, F. Harnois, J.F. Boivin, A. Ferrario, D. Dikov, S. Cheaib, G. Bonihay, C. Chayette
Journal: Journal of Hepatology (2012)
Abstract LB-287: TPX2 acts as a scaffold and co-activator protein for the oncogenic kinase Aurora B
Authors: Jyoti Iyer, Ming-Ying Tsai
Journal: Cancer Research (2012)

Abstract Aurora B kinase is a master regulator of mitosis and is over-expressed in a variety of malignancies including astrocytomas, seminomas, ependymomas, prostate cancer and non small-cell lung cancer. Several Aurora B inhibitors are currently being evaluated for their efficacy in cancer therapy. Therefore, it is critical to understand the regulation of Aurora B activity by other proteins. Aurora B forms the enzymatic core of the Chromosomal Passenger Complex (CPC). The CPC consists of three other proteins besides Aurora B: INCENP, Survivin and Borealin. All these proteins have been known to promote Aurora B activation. The mitotic protein Targeting Protein for Xenopus kinesin-like protein 2 (TPX2) co-localizes with Aurora B at several stages of mitosis, hinting at the existence of a signaling cross-talk between Aurora B and TPX2. The main purpose of our study is to determine whether Aurora B and TPX2 can cross-talk with each other during mitosis, and if found so, to decode the mechanism by which this signaling cross-talk occurs. We hypothesize that TPX2 can transmit signals to regulate Aurora B activity during mitosis. To test our hypothesis, we have performed experiments utilizing M-phase Xenopus egg extracts (XEE) which possess an abundance of mitotic proteins, and human cell lines as model systems. By performing immunoprecipitation assays (IPs) in M-phase XEE, we detected an interaction between TPX2 and the CPC proteins - Aurora B, INCENP and Survivin. This validates the existence of a signaling cross-talk between TPX2 and the CPC proteins. Moreover, IPs and microtubule pelleting assays utilizing XEE revealed that, as is typical of scaffold proteins, either too much or too little TPX2 alters Aurora B activity. Significantly, immunodepletion of endogenous TPX2 from XEE decreases the association between Aurora B and its activators- Survivin and INCENP, leading to a consequent reduction in Aurora B activity. Additionally, in vitro binding assays demonstrate that, residues 138 to 328 of Xenopus TPX2 (TPX2 B) are sufficient to enhance the interaction between Aurora B and its activator, Survivin. Further, TPX2 B also increases Aurora B kinase activity in an in vitro kinase assay. These data suggest that under endogenous conditions, TPX2 functions as a co-activator of Aurora B by increasing Aurora B-Survivin and Aurora B-INCENP interactions. Importantly, IPs with Panc-1 and CFPAC-1 pancreatic cancer cell lines suggest that this mechanism of Aurora B activation by TPX2 is likely to be conserved in human cancer cell lines. Based upon our results, we conclude that TPX2 enhances Aurora B activity by serving as a scaffold protein for assembly of the CPC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-287. doi:1538-7445.AM2012-LB-287
PTU-159 Variable Utility Of Chromogranin A Assays In The Diagnosis Of Gastric Carcinoid Type 1
Authors: RE Rossi, NG Martin, J Garcia-Hernandez, D Mandair, M Mullan, C Toumpanakis, ME Caplin
Journal: Gut (2014)

<h3>Introduction</h3> Chromogranin A (CgA) is used in the diagnosis and follow-up of patients with neuroendocrine tumours, whilst there is debate over the accuracy of CgA assays in gastric carcinoid type 1 (GC1). Clinical interpretation of CgA results may be affected by the heterogeneity between available assays. The commercial CgA assay, DAKO (DAKO, Denmark A/S, Glostrup, Denmark) is an ELISA which recognises a 23 kD C terminal fragment of CgA; the Imperial Supra-regional Assay Service radioimmunoassay (SAS Hammersmith Hospital, Imperial College, London) is a competitive radioimmunoassay raised against the whole pancreastatin molecule. Present study is aimed at comparing CgA-DAKO and CgA-SAS to determine their accuracy in the diagnosis of GC1. <h3>Methods</h3> Patients with a confirmed diagnosis of GC1 and available plasma CgA measurements according to two different assays (SAS, DAKO) were included and retrospectively reviewed. CgA values were ranked in 4 groups: 1. normal values, 2. increase &lt;2 upper limit of normal (ULN), 3.increase between 2–5 ULN, 4. increase &gt;5 ULN. <h3>Results</h3> 26 patients, 17 female and 9 male, mean age 55 years ± 11.75, were identified. At diagnosis, median CgA-DAKO were significantly higher than median CgA-SAS (81, normal range &lt;27 IU/l <i>versus</i> 34.5 pmol/l, normal range &lt;60 pmol/l, T=35.5, p &lt; 0.001). When ranking the data, the results confirmed median CgA-DAKO significantly higher than median CgA-SAS: 3 vs. 1, T=0, p &lt; 0.001. Sensitivity was 77% and 7.7% for CgA-DAKO and CgA-SAS, respectively. <h3>Conclusion</h3> CgA-DAKO shows a better sensitivity than CgA-SAS for the diagnosis of GC1. Accurate diagnostic biomarkers may identify those patients who may benefit from a closer endoscopic follow-up in cases of raised neuroendocrine markers. Further prospective studies are needed highlighting the difference in diagnostic sensitivity between assays. <h3>References</h3> Ramachandran R, <i>et al</i>. Improved diagnostic accuracy for neuroendocrine neoplasms using two chromogranin A assays. <i>Clin Endocrinol (Oxf). </i>2012;<b>76:</b>831–836 Baudin E, <i>et al</i>. Impact of chromogranin-A measurement in the work-up of neuroendocrine tumors. Ann Oncol 2001;12(Suppl 2): S79–S82 Stridsberg M, <i>et al</i>. A comparison between three commercial kits for chromogranin A measurements. Journal of Endocrinology 2003:177:337–341 Ardill JES. Circulating markers for endocrine tumours of the gastroenteropancreatic tract. Annals of Clinical Biochemistry 2008:45, 539–559 <h3>Disclosure of Interest</h3> None Declared.