tbuckley/cabot-search huggingface dataset:
AB0674 Secretory IGA: Negative Correlation with Disease Activity Measures in HLA B27 Positive Spondyloarthritis Patients:
Authors: C. Romero-Sanchez, F. Salas-Cuestas, J. Bello, I. Arias, W. Bautista-Molano, V. Parra I, D. Herrera, R. Valle-OÑAte
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The human Major Histocompatibility Complex (<i>MHC</i>) encompasses a group of genes located in chromosome 6 (6p21.3); it encodes proteins expressed on the cell surface. The HLA-B27 is a MHC class I molecule associated with spondyloarthritis (SpA); many theories related to its natural function have been postulated to explain its pathogenic role.<sup>(1–2)</sup> Relevance of HLA-B27 molecule in the mucosal immune system, the gut mucosa inflammation, and secretory IgA (SIgA) production remains unresolved. <h3>Objectives</h3> The purpose of this study was to evaluate the correlation between serum SIgA levels and disease clinical activity in a cohort of HLA B27 positive and negative SpA patients with ReA and USpA, in a clinical center in Bogota Colombia. <h3>Methods</h3> The concentration of SIgA in serum was measured by an enzyme linked immunosorbent assay and the HLA-B27 was assessed by flow cytometry, followed by Polymerase Chain Reaction with sequence specific primers, in 46 patients with USpA and ReA. Clinical gastrointestinal manifestations and activity indices (BASDAI, ASDAS x CRP and ASDAS x ESR) were collected from each patient. Statistical analysis was performed using Stata 11.2 ® software for Windows; Pearson correlation was used to measure the degree of relationship between SIgA and clinical activity depending on the HLA B27 status. The study was approved by local hospital9s ethics committee. <h3>Results</h3> 46 SpA patients completed the study with mean age of 34,8 ±12,3 years; 78,2% were men, 52,17% were HLA B27 positive, 60.9% of patients reported gastrointestinal symptoms such as diarrhea, abdominal pain, abdominal swelling and hematochezia. 63,6%, 88,6% and 100% of patients had disease activity evaluated by BASDAI, ASDAS-CRP and ASDAS-ESR scores, respectively, and 71,7% of patients had SIgA concentration above the upper normal range. The SIgA concentration was correlated with disease activity measures: BASDAI, ASDAS-CRP and ASDAS-ESR (-42% (0.0046), -37% (0.014) and -45% (0.0021) respectively); the negative coefficient correlation between SIgA and BASDAI, ASDAS-CRP and ASDAS-ESR was higher in HLA-B27 <sup>+</sup> patients -70% (0.0009), -58% (0.0093) and -57% (0.0083) than in HLA-B27 <sup>–</sup> patients. <h3>Conclusions</h3> These results suggest that SIgA levels in patients with ReA and USpA might be a correlate of disease activity measures based upon HLA-B27 status and might reflect an immunomodulatory role in these pathologies. <h3>References</h3> Bowness P. HLA-B27. Annu Rev Immunol. 2015; 33:29–48. Chatzikyriakidou A, Voulgari PV, Drosos AA. What is the role of HLA-B27 in spondyloarthropathies? Autoimmun Rev. 2011 Jun; 10(8):464–8. <h3>Disclosure of Interest</h3> None declared
RTRB-20CALCIFICATION AFTER RADIOTHERAPY IN GLIOBLASTOMA: A CASE REPORT
Authors: Martin Komenda, Birgit Surboeck, Otto Berger, Claudia Steffal, Barbara Horvath-Mechtler, Wolfgang Grisold
Journal: Neuro-Oncology (2015)

BACKGROUND: Radiation necrosis, vasculopathy, leucencephalopathy, edema or bleeding are well known delayed effects of cerebral radiation which are well documented by imaging techniques. Mineralizing microangiopathy is a late complication of radiation-induced brain injury in children and adults and has also been observed in combinations with chemotherapy and radiotherapy. We present a case of calcification in the radiated area of the tumor one year after treatment. INDEX CASE: A 42-year-old man was diagnosed with glioblastoma in the basal ganglia and the insular region on the right side. Clinically he presented with a high grade sensorymotor brachiofacial hemiparesis on the left side and neglect. After biopsy he received combined radiotherapy and chemotherapy according to Stupp-regimen. A volumetric modulated arc therapy with a total dose of 60 Gy (30 x 2 Gy) was performed. The disease was stable clinically and radiologic for one year. Then he was readmitted due progression of the hemiparesis and development of an optomotor disturbance. A cerebral CT scan revealed a calcification of the basal ganglia and in the prepontine area. The location matched exactly the former radiation field. A reevaluation of histology confirmed GMB and no indication for oligodendroglioma was noted. DISCUSSSION: Calcifications as a consequence of mineralizing microangiopathy after combined radiation and chemotherapy are described in childhood CNS neoplasms. Typical locations are the basal ganglia and subcortical white matter. In this index case, the large calcified area in the field of radiation is an unusual finding with unclear significance. As this is a rarely reported observation the prognostic relevance is not clear.
Extensive Bone Marrow Infiltration and Abnormal Free Light Chain Ratio Identifies Patients with Smoldering Myeloma At High Risk for Progression to Symptomatic Disease,
Authors: Efstathios Kastritis, Lia A Moulopoulos, Maria Gkotzamanidou, Dimitra Gika, Maria Roussou, Maria Gavriatopoulou, Magdalini Migkou, Evangelos Eleutherakis-Papaiakovou, Evangelos Terpos, Meletios Athanasios Dimopoulos
Journal: Blood (2011)
FRI0385 Clinical Characteristc of Valvular Involvement in Takayasu's Arteritis: Table 1.
Authors: N. Gao, T. Wang, W. Ci, J. Du, Z. Zhou
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Takayasu9s arteritis (TKA) is a chronic large-vessel vasculitis that predominantly affects aorta and its major branches. Cardiac lesion in TKA could reach up to 8.6%, involving valve, myocardium and coronary artery or secondary to hypertension or pulmonary hypertension due to TKA [1]. The valvular involvement is one of the causes for the unfavorable prognosis of TKA [2]. Limited data about TKA with valvular involvement in Chinese patients have been reported yet. <h3>Objectives</h3> To investigate the clinical features of valvular lesions in TKA. <h3>Methods</h3> We retrospectively analyzed 22 medical records of TKA with valvular lesions from a total of 116 TKA admitted patients in Anzhen Hospital, Capital Medical University from January 2012 to January 2015. <h3>Results</h3> The spectrum of valvular involvements were aortic regurgitation (11,50%,), mitral regurgitation (1,4.5%), aortic stenosis (1,4.5%), mitral stenosis (1,4.5%) and multiple valvular disease (7,36.5%). 64.7% of the aortic regurgitation patients had aortic root dilation. Heart failure was the commonest manifestation (63.6%). Patients with aortic regurgitation were more likely to be positive for elevated erythrocyte sedimentation rate than those without aortic regurgitation (i58.8% vs. 0, P=0.04). Glucocorticoid and/or immunosuppression were administered on 11 (50%) patients. One (4.5%) patient received Tocilizumab injection. Surgeries were performed on 12 (54.5%) patients with cardiac architecture changing reversibly within one week after operation (P&lt;0.05, Table 1). Three patients had aortic valve detachment or perivalvular leakage 6–36 months after primary valvular surgery. Three patients died during 10–46 month follow-up, with none of whom taking any anti-inflammatory treatments. <h3>Conclusions</h3> Aortic regurgitation is the prominent valvular lesion in TKA, mainly secondary to aortic root dilation. Operation could cut off the myocardium reconstruction promptly. The early surgical complication is rare, while perivalvular leakage may occur during longstanding follow-up. Poor inflammatory control might lead to adverse prognosis. <h3>References</h3> Zhu WG, Lin X, W, al. Cardiac manifestations of Takayasu9s arteritis. Chinese Journal of Allercy &amp; Cllnical Immunology. 2011, 5(3), 217–222. Soto ME, Espinola N, Flores-Suarez LF, et al. Takayasu arteritis: clinical features in 110 Mexican Mestizo patients and cardiovascular impact on survival and prognosis. Clin Exp Rheumatol. 2008, 26(3 Suppl 49):S9–15. <h3>Disclosure of Interest</h3> None declared
Cancer Therapy: Targeted Dual pH-Sensitive Lipid ECO/siRNA Self-Assembly Nanoparticles Facilitate In Vivo Cytosolic sieIF4E Delivery and Overcome Paclitaxel Resistance in Breast Cancer Therapy (Adv. Healthcare Mater. 22/2016)
Authors: Maneesh Gujrati, Amita M. Vaidya, Margaret Mack, Dayton Snyder, Anthony Malamas, Zheng-Rong Lu
Journal: Advanced Healthcare Materials (2016)

Zheng-Rong Lu, Maneesh Gujrati, and co-workers design and develop simple and smart lipid ECO/siRNA self-assembly nanoparticles, which can efficiently silence the oncogene, eukaryotic translation initiation factor 4E (eIF4E), and consequently resensitize triple-negative breast cancer (TNBC) to paclitaxel on page 2882. This approach holds great promise for alleviating drug resistance in cancer therapy. Besides TNBC, the targeted multifunctional ECO/siRNA nanoparticles represent a versatile platform technology for the delivery of therapeutic siRNAs for the treatment of various other human diseases.
The Frequency, Manifestations and Duration of Prolonged Cytopenias after First Line Fludarabine-Combination Chemotherapy for Chronic Lymphocytic Leukemia and Non-Hodgkin Lymphoma
Authors: Saar I. Gill, Dennis Carney, David S. Ritchie, Max Wolf, David Westerman, H. Miles Prince, Henry Januszewicz, John F. Seymour
Journal: Blood (2008)
Healthy lifestyle halves heart risk in people at high genetic risk, study finds
Authors: Susan Mayor
Journal: BMJ (2016)

A healthy lifestyle, including regular physical activity, eating healthily, and avoiding obesity and smoking, nearly halves the risk of coronary events in people at high genetic risk for coronary artery disease, results from a combined analysis of four large studies have shown.1

Genetics and lifestyle both contribute to individual risk of coronary artery disease, but the extent to which increased genetic risk can by offset by a healthy lifestyle was unknown.

Researchers quantified the genetic risk for coronary artery disease in …
THU0014 CCR6 Expression Regulates Arthritis in A T Cell Dependent Manner
Authors: M. Bonelli, A. Puchner, L. Goeschl, S. Hayer, B. Niederreiter, J.S. Smolen, C. Scheinecker, S. Blueml
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial infiltration of various inflammatory cells. Chemokines are involved in controlling the recruitment of different cell types into the synovial membrane. Increased production of MIP-3-a and accumulation of CCR6 expressing mononuclear cells can be found in joints of RA patients. CCR6 expression has also been reported on CD4<sup>+</sup> T cells, in particular regulatory as well as Th17 cells. Recent data suggest that CD25<sup>–</sup>Foxp3<sup>+</sup> T cells upregulate CCR6 and promote arthritis. <h3>Objectives</h3> In this study, we investigated the role of CCR6 in the pathogenesis of arthritis using different arthritis models. <h3>Methods</h3> Clinical as well as histological signs of arthritis were investigated in the collagen-induced arthritis (CIA), K/BxN serum transfer arthritis and in the human tumor necrosis factor (hTNFtg) arthritis model, comparing <i>wt</i> and <i>CCR6–/–</i> mice. We analyzed the phenotype of lymph node cells by flow cytometry and cytokine concentrations in serum. Anti-collagen antibodies and cytokines were measured by enzyme-linked immunosorbent assay. <h3>Results</h3> Since CCR6 is an important component of the innate immune system we compared the development of arthritis in <i>CCR6–/–</i> mice in 2 different arthritis models known to be T cell independent, the K/BxN serum transfer arthritis and hTNFtg arthritis. In both models, we did not detect any significant differences in clinical signs of inflammation or histological severity of arthritis between wt and CCR6–/– mice. In additon, we could not detect differences in bone density between <i>wt</i> and <i>CCR6–/–</i> mice. To investigate the role of CCR6 as part of the adaptive immune system in the development of arthritis we induced CIA in <i>wt</i> and <i>CCR6–/–</i> mice. <i>CCR6–/–</i> mice were almost completely protected from CIA. Analyses of T cell subsets by flow cytometry revealed a significant reduction of CD25<sup>–</sup>Foxp3<sup>+</sup> T cells. <h3>Conclusions</h3> These data suggest that CCR6 is not crucially involved in innate immunity driven arthritis, but is necessary for the development of autoimmune arthritis. Importantly, CCR6 is necessary for the generation of pathogenic CD25<sup>–</sup>Foxp3<sup>+</sup> T cells in CIA, suggesting an important function of CCR6 on T cells in the development of autoimmune arthritis. <h3>Disclosure of Interest</h3> None declared
Combined Modality Treatment of Two or Four Cycles of ABVD Followed by Involved Field Radiotherapy in the Treatment of Patients with Early Stage Hodgkin’s Lymphoma: Update Interim Analysis of the Randomised HD10 Study of the German Hodgkin Study Group (GHSG).
Authors: Andreas Engert, Annette Pluetschow, Hans T. Eich, Richard Herrmann, Bernd Doerken, Lothar Kanz, Richard Greil, Jana Markova, Beate Pfistner, Andreas Josting, Konrad Mueller-Hermelink, Ralf P. Mueller, Volker Diehl
Journal: Blood (2005)
ATCT-28THE MODIFIED ATKINS DIET IN RECURRENT GLIOMA: A RETROSPECTIVE REVIEW
Authors: Hatim Attar, Sarah Rolfe, Andrew Sloan, Lisa Rogers
Journal: Neuro-Oncology (2015)

BACKGROUND: Glioblastoma (GBM) generates ATP via glycolysis even under oxygenation (Warburg effect). A strict ketogenic diet (KD) reduces glucose availability and increases ketone bodies. KD also reduces reactive oxygen species and downregulates signaling pathway genes associated with GBM growth (Scheck AC. 2012). Efficacy of KD as compared to standard diet is demonstrated in mouse GBM xenograft models (Abdelwahab MG. 2012). Rieger (Rieger J. 2014) demonstrated compliance in 17/20 recurrent GBM patients treated with a modified KD (up to 60 gm/day carbohydrate allowed). We report our experience with the modified Atkins diet (MAD) a high fat, carbohydrate-restricted (2-5% of total calories) diet in recurrent glioma patients. METHODS: Retrospective review of glioma patients treated with MAD at our institution. RESULTS: 13 patients aged 23-72 years with recurrent gliomas (7 GBM, 4 low grade, 2 anaplastic) were treated with MAD. IDH 1 was negative in 10/11 available tumor specimens. Diet was combined with chemotherapy or targeted agents in 9 patients. All created home meal plans. Two intermittently used a prepared food supplement to achieve diet guidelines. Time on diet ranged 1-21 mos.; 4 continue at 1.5 to 21 months. Two patients were noncompliant. Diet was discontinued because of disease progression in 4 (at 1-12 months). Two others discontinued the diet because of weight loss (1) and inconvenience (1). One experienced a serious adverse event (SAE) of renal calculus at 11 months. CONCLUSIONS: The MAD was tolerated in the majority of patients with recurrent glioma. There was one SAE. We are unable to correlate outcome with tumor IDH1 mutational status: IDH1 was negative in all but one tumor studied. The benefit of MAD and optimal combination with radiation and/or chemotherapy requires prospective study.
In Vitro Effects of the Combination of Idarubicin (IDA) with Suberoylanilide Hydroxamic Acid (SAHA) or Valproic Acid (VPA) in Leukemia Cell Lines.
Authors: Blanca Sanchez-Gonzalez, Koyu Hoshino, Carlos Bueso-Ramos, Hui Yang, Emile Youssef, Yanis Boumber, Claritsa Santos-Malave, Guillermo Garci-Manero
Journal: Blood (2004)
THU0227 Adolescent and Young Adult Care in Adult Rheumatology Clinics
Authors: E. Bruce, J. Fox, P. Watson, J. McDonagh
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The importance of transitional care for young people from paediatric to adult rheumatology is well established. However, in most rheumatology departments there will be a significantly larger cohort of older adolescents and young adults (AYAs) that enter adult services de-novo than will have transitioned from paediatric services. <h3>Objectives</h3> Our aim was to evaluate AYA care within adult Rheumatology clinics, in particular focusing on use of the HEEADDSS psychosocial interview. <h3>Methods</h3> A review of clinical correspondence for patients aged 16–25yrs attending adult rheumatology clinics at University Hospital of South Manchester, between February 2015 and May 2015 was undertaken. Data collected included demographics, diagnosis and evaluation of documentation of the components of the HEEADDSS screen. <h3>Results</h3> 193 appointments were issued for 16–25yr olds, representing 5% of the total number of appointments. 103 were new referrals, with a majority from general practice. Age distribution was even, over two thirds were female. The "did not attend" rate was 10%. 36 had a confirmed inflammatory condition, 27 were under investigation for a possible inflammatory arthritis and 47 had a non inflammatory condition. Of the HEEADDSS criteria the most often documented was education/employment at 31%, with exercise at 19%. <h3>Conclusions</h3> The AYA group is well represented within this secondary care setting. Documentation of the HEEADDSS criteria was suboptimal. There may be wider implications of this on health outcomes. The first step towards improving care for this cohort is to establish an awareness within the adult team of the particular needs of this patient group, AYA health is not just a concern for paediatric rheumatologists. <h3>Disclosure of Interest</h3> None declared
A Phase I Study of the Anti-Natural Killer Inhibitory Receptor (KIR) Monoclonal Antibody (1-7F9, IPH2101) in Elderly Patients with Acute Myeloid Leukemia (AML): Clinical and Immunological Effects of a Single Dose Followed by Repeated Dosing.
Authors: Norbert Vey, Jean-Henri Bourhis, Herve Dombret, Dominique Bordessoule, Thomas Prébet, Aude Charbonnier, Stephane de Botton, Nicolas Boissel, Christine d'Arnoux, Francois Romagne, Pascale Andre, Jerome Tiollier, Patrick Squiban, Didier Blaise, Daniel Olive
Journal: Blood (2009)
The Abl Carboxyl Terminal Region Is Required for the Induction of Acute Lymphoblastic Leukemia by V-Abl but Not for the Induction of Myeloproliferative Disease by BCR/ABL or V-Abl.
Authors: Yongli Ji, Alec W. Gross, Xiaowu Zhang, Ruibao Ren
Journal: Blood (2004)
Graft Versus Host Disease (GVHD) Prophylaxis with Everolimus and Tacrolimus Is Associated with a High Incidence of Sinusoidal Obstruction Syndrome and Microangiopathy – Results of the EVTAC Trial
Authors: Uwe Platzbecker, Malte Bonin, Eray Goekkurt, Joergen Radke, Alexander Kiani, Jan Stoehlmacher, Johannes Schetelig, Gerhard Ehninger, Martin Bornhauser
Journal: Blood (2008)
O101 : Histone variant macroH2A1 orchestrates escape from hepatocyte senescence during ageing and cancer
Authors: M. Borghesan, C. Panebianco, F. Rappa, J.M. Sedivy, M. Buschbeck, F. Cappello, T. Mazza, V. Pazienza, M. Vinciguerra
Journal: Journal of Hepatology (2015)
S78 Lymphopaenia and increased ace levels stratify sarcoidosis patients to underlying increase in IFN-γ + lymphocyte and TNF-α+ monocytes respectively
Authors: YK Kendrick, SL Cole, R Hoyles, LP Ho
Journal: Thorax (2016)

<h3>Introduction</h3> Sarcoidosis is a heterogeneous disease, and different mechanisms may contribute to disease activity at any one time. Both TH1 lymphocyte (IFN-γ+, IL-2+ CD4 T cells) and activated tissue macrophages contribute to the formation of granuloma and are established disease pathways. More recently, monocytes (precursors of tissue macrophages) have also been implicated. We reasoned that if we could identify a commonly used clinical test as a biomarker for these disease pathways, it could be used as a disease activity marker, and to guide evaluation of new therapies and repositioning of current drugs. In this study, we question whether serum ACE and circulating lymphocyte count correlated with different cellular immune function. <h3>Methods</h3> 44 consecutive patients fulfilling the ATS-WASOG diagnostic criteria for sarcoidosis within a 2-year period were recruited. Patients on treatment, current cigarette smokers, inter-current immune disease and malignancies were excluded. Blood samples from all patients were processed contemporaneously for ACE, lymphocyte counts and CD4 T cell intra-cellular cytokine staining (ICS) for IFN-γ, IL-2 and IL-17 and CD14hi monocytes ICS for TNF-α. <h3>Results and discussion</h3> We found no correlation between lymphocyte count and ACE (r = −0.2; p = 0.86) suggesting that these two abnormalities reflected independent processes. Lymphopaenia was significantly correlated with markers of activated CD4 T cells (IFN-γ, IL2+ and TNF-α+) (r = −0.50, 0.50 and 0.60 respectively; all p &lt; 0.001; Spearman Rank Sum test); while ACE only correlated with level of TNF-α+ monocytes (r = 0.60; p &lt; 0.0001). <h3>Conclusions</h3> These results suggest that high ACE and lymphopaenia (i) reflect disease activity (ii) are likely to be endpoints of two different mechanistic pathways, and (iii) that they could potentially stratify patients into those with lymphocytic dominant and monocyte dominant disease processes. Thus a monocyte pathway inhibitor could be used specifically in patients with high ACE levels while drugs that target T cell activity may be targeted to those with lymphopaenia.
What Is the Appropriate Dose Attenuation System of RCHOP for Elderly DLBCL Patients? - A Single Institutional Analysis in 115 Cosecutive Patients From Japan -
Authors: Akira Tanimura, Risen Hirai, Atsushi Sato, Miki Nakamura, Masataka Takeshita, Shotaro Hagiwara, Akiyoshi Miwa
Journal: Blood (2012)
Reply
Authors: Andreas Drolz, Valentin Fuhrmann
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. Reply: We appreciate the interest of Dr. Desborough and colleagues in our work.1 They present a retrospective analysis based on a large prospectively collected data set including 1,313 cirrhosis patients admitted to 85 UK hospitals over 4 weeks in 2013,2 showing that fibrinogen predicts 28‐day mortality independently of other relevant baseline parameters and bleeding status. These findings support the results of our study. However, our study did not evaluate the direct relationship between coagulation parameters, such as fibrinogen and mortality. Fibrinogen levels may indeed reflect severity of the underlying disease. Such a relationship is well established for prothrombin time and international normalized ratio, which are included in several scoring systems for liver disease (e.g., Model for End‐Stage Liver Disease, Chronic Liver Failure–Sequential Organ Failure Assessment). However, in some of our critically ill patients, we observed a dramatic decrease in fibrinogen, which was not strictly related to severity scores for liver disease. Factors associated with the acute event (e.g., infections) seem to contribute to hemostatic alterations, including low fibrinogen in critically ill cirrhosis patients. To our knowledge, our study is the first to describe the direct relationship between fibrinogen and major bleeding events in a large cohort of critically ill cirrhosis patients. The question of whether substitution of fibrinogen may prevent bleeding or facilitate better bleeding control during active bleeding episodes cannot be answered by the current study. We agree that coagulation disturbances, especially hypofibrinogenemia, in cirrhosis and their impact on risk of bleeding and death require further investigations. Moreover, it is unclear whether substitution of blood or coagulation products may decrease bleeding risk or improve outcome in critically ill cirrhosis patients. Thus, further studies, including prospective interventional trials in different cohorts of cirrhosis patients, are definitely needed.