tbuckley/cabot-search huggingface dataset:
Soundings: Weapons of mass destruction kill dinosaurs
Authors: George Dunea
Journal: BMJ (2003)

In a second I realised that my eyes had deceived me, that I had misread the two headings and falsely combined them, and that “Saddam's weapons of mass destruction” was a separate article from “Killer dinosaurs.” Nor did I pay attention to such items as “Aliens among us,” “Psychic advice from Serena,” “Conspiracies,” and “The chamber of the bizarre.” But my interest was drawn to an article supposedly written by a former funeral director claiming that 35 people are buried, embalmed, or cremated alive each day in the United States.

“It is a closely guarded industry secret,” writes the author, “that nearly one in 50 people who are pronounced dead aren't dead after all—they're comatose” and “everybody has heard of people waking up at their own funeral.” Hence the need to take precautions to avoid being painlessly bled to death and embalmed prematurely, or waking up “six feet under in a stuffy coffin” or in a “flame-drenched crematorium oven.”

Some modern technology is no better than applying a mirror to the mouth and nose of the potential traveller to the underworld. For what are we to make of an item last year in a major Swedish newspaper reporting that “soon before the organ donation the patient started to move. The doctors had believed that the man was dead, but a check revealed that he was alive, and the organ donation was rapidly cancelled.”

Also to feed a morbid imagination is a newspaper item describing how doctors thought that they felt a pulse in a woman who had been placed in a body bag in a refrigerator for three hours. Mercifully they were wrong. Yet in The Premature Burial Edgar Allan Poe wrote that “to be buried alive is, beyond question, the most terrific [agony] which has ever fallen to the lot of mere mortals. That it has frequently, very frequently, so fallen will scarcely be denied by those who think. The boundaries that divide Life from Death are at best shadowy and vague. Who shall say where one ends, and the other begins?”

But we must not believe everything we read. And we may definitely rest reassured that the dinosaurs are in no danger of being exterminated by smallpox, nerve gas, or atomic radiation.
FRI0252 Behcet's Disease and Pregnancy: What is the Relationship?
Authors: M. Gilio, G. Tramontano, S. D'Angelo, P. Leccese, A. Padula, R. Scarpa, I. Olivieri
Journal: Annals of the Rheumatic Diseases (2015)

<b>Objective: </b> The impact of migraine on physical, social, and emotional performance is considerable, yet it remains an underdiagnosed disorder. ID-Migraine is a validated migraine-screening tool developed to facilitate diagnosis. This study evaluated the validity and use of the Turkish version of the ID-Migraine screener (ID-Ms) in the workplace, and measured the impact of headache on disability, productivity, and quality of life among the workforce. <b>Methods: </b> A total of 465 employees from four companies were interviewed for screening with the ID-Ms. Subjects were included in the study if they reported two or more headaches in the past 3 months and gave a positive answer to one of the two ID-Ms prescreening questions. Eligible subjects completed the ID-Ms, the Migraine Disability Assessment Questionnaire, and the Medical Outcomes Study 36-Item Short Form Health Survey. Subjects were then evaluated for confirmation of their diagnosis according to the <i>International Classification of Headache Disorders</i>, 2nd edition (ICHD-2) criteria. <b>Results: </b> A total of 227 subjects (mean age 31.9 ± 5.9 years; 65.6% women) completed the study. Migraine was diagnosed in 106 of the 227 subjects (46.7%) according to the ID-Ms and in 117 of the 227 subjects (51.5%) according to ICHD-2 criteria. The sensitivity of the ID-Ms was 70.9%, specificity was 79.1% and Cohen kappa value was 0.50. Workdays lost over the previous 3 months due to headache amounted to 8.7 ± 9.5 days for migraine-positive and 4.9 ± 6.6 days for migraine-negative subjects. <b>Conclusion: </b> The Turkish version of the ID-Migraine screener is a valid tool for identifying subjects with migraine in the workplace.
TREATMENT OF PENETRATING WOUNDS OF THE CHEST.
Authors: G Tsehai, G Wolde-Michael
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0904 Prevalence of Atypical Fractures in a Tertiary Hospital
Authors: M. Uriarte, C.A. Egües, C.F. Meneses, N. Errazquin, J. Belzunegui, G. De la Herrán
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Biphosphonates are considered the first line treatment for osteoporosis. One of the side effects of the continuous treatment is the development of atypical fractures. These are generally subtrochanteric, although they can appear anywhere in the femoral diaphysis, with a low prevalence (1.1% of all the femur fractures). Their incidence grows with the time to exposure to bisphosphonates. Radiologically they show a traverse trace or slightly oblique, non comminuted with formation of a medial spicule and the majority of the cases show thickness of the lateral cortical. They appear after a minimum traumatism or spontaneously. <h3>Objectives</h3> To determine the prevalence or atypical fractures according to the American Society of Mineral and Bone Research (ASMBR) criteria between 2011 and 2014 in the Universitary Hosptial of Donostia (Guipúzcoa, Spain). <h3>Methods</h3> Retrospective research of clinical data of patients operated of hip fracture and/or femur fractures between November 2011 and December 2014 Variables included were: age, sex, race, clinical features, treatment received, and presence or absence of diseases and pharmacological treatments that participate in the bone remodeling. <h3>Results</h3> 921 patients operated of hip fracture and 76 of diaphyseal fracture. 6 patients met the clinical and radiologic criteria of the ASMBR for an atypical fracture, 100% of these had recieved a long term treatment with biphosphonates and ment the 6,57% of the diaphyseal fractures, the 0,12% of the hip fractures and the 0,6% of the total of the fractures studied. Two of the patients also received treatment with other antirresortive and osteoformating treatments. The median age was 75 years (IQR=20). The most used biphosphonate was Alendronate, beeing in the 66,6% of the patients the first treatment. The median time of expotion to biphosphonates was 8,5 years (IQR=3). In the 83,3% of the patients the fracture was situated in the medial third of the femoral diaphisis. <h3>Conclusions</h3> In our study the prevalence of atypical fractures with biphosphonates was low, a 0,6% of all of the fractures studied. <h3>Disclosure of Interest</h3> None declared
Death underfunded
Authors: K. Abbasi
Journal: BMJ (2001)

It can't be much fun working in the pathology service in the United Kingdom as it lurches from one crisis to another with regular knocks from the government and the media. There have been mistakes, notably the practice of retaining organs without consent, and it will be some time before the public is reassured.1 Apportioning blame in the latest furore to blight the pathology service—bodies being stored outside mortuaries—is, however, not so clear cut.

Last week the striking image of seven corpses stored in a hospital chapel, draped in sheets with the legs and face of one body visible, forced the resignation of Ken Williams, the chief executive of Bedford Hospital.2 A damaged door …
Hemodynamic Effects of Continuous Positive and Negative Pressure Breathing in Normal Man
Authors: KAYE H. KILBURN, HERBERT O. SIEKER
Journal: Circulation Research (1960)

Alterations in cardiac output, central blood volume, and arterial and central venous pressures were studied in 36 young men subjected to continuous negative or continuous positive pressure breathing. Negative pressure breathing increased cardiac output, stroke volume, and, to a lesser extent, central blood volume. Positive pressure, without overbreathing, decreased both cardiac output and central blood volume, but hyperventilation reversed these effects. On the basis of these observations, it is concluded that decreased intrathoracic pressure is important in maintaining or increasing the blood available to the heart in man, particularly during circulatory stress.
Deoxypentose Nucleic Acids and Nucleoproteins of Malignant Tissues. III. Electrophoretic Studies of the Deoxypentose Nucleic Acids of Lymphoma #1 and of Calf Thymus
Authors: Joseph Shack, Robert J. Jenkins
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Deoxypentose Nucleic Acids and Nucleoproteins of Malignant Tissues. III. Electrophoretic Studies of the Deoxypentose Nucleic Acids of Lymphoma #1 and of Calf Thymus Get access Joseph Shack, Joseph Shack Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert J. Jenkins Robert J. Jenkins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 5, May 1957, Pages 749–755, https://doi.org/10.1093/jnci/18.5.749 Published: 01 May 1957 Article history Received: 06 February 1957 Published: 01 May 1957
PTU-292 Optimising the use of immunomodulators and biologics for inflammatory bowel disease in a peripheral district general hospital
Authors: A Vaishnavi, K Johns
Journal: Gut (2015)

<h3>Introduction</h3> Annual audit of steroid use (longer than 3 months or more than 2 courses in the last year), immunomodulator drugs (IM) and anti-TNF is recommended for inflammatory bowel disease (IBD) services. A local audit was carried out to identify the percentage of IBD patients on long term steroids and to ascertain if the use of IM and anti-TNF therapy was appropriate. <h3>Method</h3> 396 patients were identified from the IBD register. Of these 77 were excluded (11 moved away, 10 died, 56 not seen in clinic for &gt;12 months). The medical records of the remaining 319 patients (CD 114, UC 182, IBDu 23) were reviewed and relevant data regarding steroid, IM and anti-TNF use was recorded. <h3>Results</h3> 152/319 patients (47%) were on regular 5-ASAs and had not received &gt;2 courses or &gt;3 months of steroids in previous 12 months. 37 (11%) were not on any regular medication. The remaining 130 patients (CD 79, UC 43, IBDu 8) had history of steroid, IM or anti-TNF use. Steroid use of &gt;3 months was evident in 14 patients (10.7%). 13 of the 14 had been tried on IM drugs and 1 had declined. 7 patients (5%) received &gt; 2 courses of steroids in 12 months and all had been tried on IM drugs. 126/319 patients (39%) had been started on Azathioprine or Mercaptopurine, but 26 (20.6%) had discontinued due to intolerance. Use of Methotrexate was low; 10 patients (&lt;1%) were currently on treatment, 5 had declined and 2 had previous intolerance. The number of patients on anti-TNF was relatively small. 35 patients with CD were treated with anti-TNF. Primary non-response was seen in 4 patients (11%), discontinuation due to side effects occurred in 6 (17%) and deep remission in 3 (8.5%) after more than two years of treatment. Infliximab was stopped in the 3 patients in deep remission in accordance with STORI trial criteria.<sup>1</sup>1 had to restart due to relapse after 4 months, the other 2 remain in remission after 7 months. <h3>Conclusion</h3> All 21 patients requiring frequent courses or on long term steroids had been offered IM drugs with 95% starting treatment. Optimisation of IM was attempted in all patients with dosing based on weight and TPMT levels. Our strategy has recently changed and we now use 6 TGN levels for dose optimisation with review at the monthly Virtual Biologics and Immunomodulator clinic. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Louis E, Mary J-Y, Vernier-Massouille G. Maintenance of remission among patients with Crohn’s disease on antimetabolite therapy after Infliximab therapy is stopped. Gastroenterology 2012;142:63–70
Clinical Features, Outcome and Prognostic Factors For Survival and Evolution To Multiple Myeloma Of Solitary Plasmacytomas: A Report Of The Greek Myeloma Study Group In 97 Patients
Authors: Eirini Katodritou, Evangelos Terpos, Argiris S. Symeonidis, Anastasia Pouli, Charikleia Kelaidi, Marie-Christine Kyrtsonis, Maria Kotsopoulou, Sosana Delimpasi, Anna Christoforidou, Nikolaos Giannakoulas, Nora-Athina Viniou, Ekaterini Stefanoudaki, Christina Hadjiaggelidou, Dimitrios Christoulas, Evgenia Verrou, Vassiliki Gastari, Sofia Papadaki, Freideriki Patakiouta, Efstathios Kastritis, Alexandra Kouraklis, Pavlina Konstantinidou, Achilles Anagnostopoulos, Konstantinos Zervas, Meletios A. Dimopoulos
Journal: Blood (2013)
A Study of Urinary &lt;italic&gt;β&lt;/italic&gt;-Glucuronidase Activity in the Production of Bladder Tumors in Rats&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Helen M. Dyer, Harold P. Morris, Grace E. Maupin
Journal: JNCI Journal of the National Cancer Institute (1960)

Bladder tumors developed in female Fischer-strain but not in female Buffalo-strain rats fed diets containing N-2-fluorenylacetamide and 2 percent dl-tryptophan or 0.8 percent indole. Only insignificant differences between rats of the two strains were observed in the weight curves, in urinary β-glucuronidase activities, or in chromatograms of aromatic metabolites of tryptophan and indole in the urine. Little evidence was obtained to support the hypothesis that urinary β-glucuronidase and o-aminohydroxy metabolites of tryptophan were involved. The increase in the number and amounts of aromatic metabolites excreted in the urine by the rats fed tryptophan or indole suggests the possibility that these metabolites may affect the bladder epithelium as a contributing factor in the induction of cancer by N-2-fluorenylacetamide.
Prognostic Evaluation of Disease Outcome in Solid Tumors Investigated With 64Cu-ATSM PET/CT
Authors: Egesta Lopci, Ilaria Grassi, Domenico Rubello, Patrick M. Colletti, Silvia Cambioli, Alessandro Gamboni, Fabrizio Salvi, Gianfranco Cicoria, Filippo Lodi, Claudio Dazzi, Sandro Mattioli, Stefano Fanti
Journal: Clinical Nuclear Medicine (2015)

Purpose 64Cu-ATSM is a very promising PET radiopharmaceutical for tumor imaging of hypoxia. One of the advantages of this compound compared with other hypoxia-avid tracers is the high tumor-to-background signal offered, which guaranties facilitated tumor delineation. This study analyzes optimal semiquantitative and quantitative parameters obtained by 64Cu-ATSM PET/CT in the same cohort of patients with special focus on their correlation to disease outcome. Patients and Methods A prospective recruitment of 18 consecutive patients (M:F, 13:5; mean age, 60.7 years) with locally advanced non–small cell lung cancer (n = 7) or head and neck cancer (HNC) was performed. Each participant received 105 to 500 MBq of tracer according to body size and was scanned in a 3-dimensional mode PET/CT 60 minutes after tracer injection. PET images were reconstructed and visualized on a GE Advanced 4.6 workstation for the definition of semiquantitative and quantitative parameters: SUVmax, SUVratio-to-muscle, hypoxic tumor volume (HTV), and hypoxic burden (HB = HTV × SUVmean). These data were subsequently correlated to disease outcome, expressed in terms of progression-free survival calculated on a follow-up period with a median of 14.6 months. Results All patients showed a moderately to highly increased uptake of 64Cu-ATSM in tumor lesions, with a mean SUVmax of 5.2 (range, 1.9–8.3) and mean SUVratio of 4.4 (range, 1.6–6.8). In addition, a broad range of HTV and HB was defined as mean values of 99.3 cm3 (range, 2.5–453.7 cm3) and 301 (4.2–1134), respectively. Receiver operating characteristic analysis identified as reference cutoffs with respect to disease outcome with the following values: SUVmax >2.5 (AUC, 0.57; sensitivity, 88.9%; specificity, 50%), SUVratio ≤4.4 (AUC, 0.60; sensitivity, 50; specificity, 83.3%), HTV >160.7 cm3 (AUC, 0.61; sensitivity, 55.6%; specificity, 75%), and HB >160.7 (AUC, 0.67; sensitivity, 58.3%; specificity, 83.3%). In our cohort, HB showed a statistically significant difference in terms of mean values on the analysis of variance test with respect to disease progression (P = 0.04). On univariate analysis, Cox regression confirmed these findings and showed a significant correlation to progression-free survival for HB (P = 0.05) and HTV (P = 0.02). Conclusions In our cohort, the definition of optimal semiquantitative and quantitative parameters on 64Cu-ATSM PET/CT seems feasible and in line with previously published data. However, when considering the prognostic role with respect to disease outcome, the more robust parameters are represented by HTV and HB.
Nuclear Receptor NR1H3 in Familial Multiple Sclerosis
Authors: Zhe Wang, A. Dessa Sadovnick, Anthony L. Traboulsee, Jay P. Ross, Cecily Q. Bernales, Mary Encarnacion, Irene M. Yee, Madonna de Lemos, Talitha Greenwood, Joshua D. Lee, Galen Wright, Colin J. Ross, Si Zhang, Weihong Song, Carles Vilariño-Güell
Journal: Neuron (2016)
Failure of Activated Trypsin to Cause Experimental Acute Hemorrhagic Pancreatitis
Authors: R E MATHEWS, N T McPHEDRAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTU-070 The fate of epithelial keratins in recent-onset and long-standing colitis in remission
Authors: A Assad-Sangabi, C Evans, D Majumdar, SS Cross, BM Corfe, AJ Lobo
Journal: Gut (2015)

<h3>Introduction</h3> Intermediate filaments (IF), which mainly consist of keratins (K), are one of the main components of the human cell cytoskeleton. K8, K18 and K19 constitute the main keratins in the intestinal epithelial cells. We have previously shown increased expression of epithelial keratins in the IF fraction from long-standing UC (&gt;20 years) in remission (LSPC) relative to recent –onset ulcerative colitis (≤5 years) in remission (ROUC) using proteomic iTRAQ-based analysis.<sup>1</sup>Whether this reduced expression is due to change in solubilisation or reduced total expression is unknown. We aimed to clarify the fate of epithelial keratins during UC disease evolution in the two cohorts. <h3>Method</h3> Soluble proteomes were extracted from individual biopsies in patients with LSPC in clinical, endoscopic and histological remission (n = 10) and ROUC in remission (n = 8). Median interval from last relapse to the index endoscopy in LSPC and ROUC was 31 and 1 month, respectively. Median histological activity index in both groups were 0 (range 0–1). An iTRAQ-compatible extraction protocol for soluble proteins was applied. Inter-group comparisons were made using in-house algorithms based on t-testing with multiple test correction. Validation of iTRAQ results was carried out with immunoblotting on pooled and individual samples using monoclonal antibody against K8. These outcomes were then compared with our previous insoluble proteome analyses.<sup>1</sup> <h3>Results</h3> Comparative iTRAQ analysis of the soluble fraction showed no statistically significant log fold changes in K8, K18 and K19 levels in LSPC relative to ROUC and normal controls. Median relative K8 concentration in IF/soluble proteome fraction in individual LSPC and ROUC samples were 1.54/10.34 and 0.03/10.93, respectively. Relative K8 concentration was significantly higher in LSPC relative to ROUC in the IF fraction (p = 0.001), whereas the same comparison did not reach statistical significance for the soluble fraction (p = 0.82). <h3>Conclusion</h3> This study suggests relative total increase in expression of epithelial keratins in colonic epithelial cells during LSPC compared to the levels in ROUC. Comparing K8 IF and soluble bands in ROUC showes change in solubilisation relative to control, which in turn suggest effect of recent inflammation on increased keratin solubility in this group. Whether restoration of K8 is a marker of deep remission beyond histological and endoscopic remission needs to be further investigated. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Corfe BM, Majumdar D, Assadsangabi A, Marsh AMR, Cross SS, Connolly JB, Evans CA, Lobo AJ. Inflammation decreases keratin level in ulcerative colitis; inadequate restoration associates with increased risk of colitis-associated-cancer. <i>BMJ Open Gastroenterol</i>., In press