tbuckley/cabot-search huggingface dataset:
Development of multi-channel radiofrequency (RF) interstitial hyperthermia system compatible with high-dose rate iridium-192 brachytherapy
Authors: N. Uchida, M. Notani, N. Yamamoto, H. Kitagaki, H. Kato
Journal: Journal of Clinical Oncology (2004)

9694 Background: We have developed a multi-channel RF interstitial hyperthermia system compatible with the high-dose rate Iridium-192 remote after loading system (Ir-192 RALS). The purpose of this presentation is to evaluate the heating characteristics of the system. Methods: The system is composed of eight channel RF signal generators, which can be controlled individually. Each RF generator consists of two types of electrodes: 1) an internal electrode made of stainless steel, which is originally an Ir-192 RALS applicator; and 2) a shared rectangular external electrode made of copper plate. For the computer simulation, we used simulation software (e-m CAD system, MAFIA ver. 3.20, CST, Germany) to calculate RF field distribution, magnetic field distribution and the specific absorption rate (SAR) distribution, in an arrangement using 4 needles inserted in a square-like formation, 2cm in distance from one another. For the experiments using the agar phantom, we generated a 5W 13.56 MHz RF signal for 5 minutes for 4 electrodes in the same square fashion. Results: The results from the computer simulation showed that SAR distribution outside each electrode was elevated, but the area inside the 4 electrodes did not show temperature elevation. The results from the experiments using the agar phantom showed a temperature increase in the center of the area surrounded by the 4 electrodes. Conclusions: Using an independently controlled RF signal, the results from the experiments with the agar phantom showed satisfactory temperature rise. The RF interstitial system we developed can provide greater heating volume compared to using a single internal electrode or multiple electrodes with a single generator. In addition, our system is compatible with the Ir-192 RALS, allowing for less-invasive interstitial hyperthermoradiotherapy by eliminating the trauma of needle re-insertion. No significant financial relationships to disclose.
NON-NEUROLOGICAL LESIONS SIMULATING PROTRUDED INTERVERTEBRAL DISK
Authors: H H YOUNG
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Musicians
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Summer Wind
Authors: Ersilia M. DeFilippis
Journal: JAMA Cardiology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Editorial: Research in general practice.
Authors: C F Borchgrevink
Journal: BMJ (1975)

1975 3 search procedure).If gonadotrophins and testosterone are low, hypothalmic or pituitary disease is likely.If gonadotrophins are high and testosterone very low then androgen therapy is probably indicated, if only to prevent or treat osteoporosis.Until further research has been conducted the less extreme "normal biochemical abnormalities" of advancing testicular age should probably be left alone.
MINERAL AND PROTEIN METABOLISM IN OSTEOLYTIC METASTASES
Authors: D LASZLO, C A SCHULMAN, J BELLIN, E D GOTTESMAN, A SCHILLING
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract P4-08-02: APOBEC3B upregulation by the PKC-NFκB pathway in breast cancer
Authors: J McCann, B Leonard, G Starrett, L Kosyakovsky, A Molan, M Burns, R McDougle, P Parker, W Brown, R Harris
Journal: Cancer Research (2016)

Abstract Overexpression of the antiviral DNA cytosine deaminase APOBEC3B has been linked to somatic mutagenesis in breast and other cancer. Human papillomavirus (HPV) infection accounts for APOBEC3B upregulation in cervical and head/neck cancers. However, the responsible mechanisms are unclear for non-viral malignancies such as breast cancer. Here, we demonstrate APOBEC3B upregulation through the PKC-NFκB pathway. PKC activation by the diacylglycerol mimic PMA causes specific and dose-responsive increases in APOBEC3B mRNA, protein, and activity levels, which are strongly suppressed by PKC and NFκB inhibition. Induction correlates with RELB (but not RELA) recruitment to endogenous APOBEC3B implicating non-canonical NFκB signaling. Relevance to tumors is supported by PKC inhibitor-mediated APOBEC3B downregulation in multiple breast cancer cell lines. These data establish the first mechanistic link between APOBEC3B and a common signal transduction pathway, suggesting that existing PKC-NFκB inhibitors could be repurposed to suppress cancer mutagenesis, dampen tumor evolution, and decrease the probability of adverse outcomes such as drug resistance and metastases. Citation Format: McCann J, Leonard B, Starrett G, Kosyakovsky L, Molan A, Burns M, McDougle R, Parker P, Brown W, Harris R. APOBEC3B upregulation by the PKC-NFκB pathway in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-08-02.
Tumor-Infiltrating Lymphocytes: A Predictive and Prognostic Biomarker in Neoadjuvant-Treated HER2-Positive Breast Cancer
Authors: Barbara Ingold Heppner, Michael Untch, Carsten Denkert, Berit M. Pfitzner, Bianca Lederer, Wolfgang Schmitt, Holger Eidtmann, Peter A. Fasching, Hans Tesch, Christine Solbach, Mahdi Rezai, Dirk M. Zahm, Frank Holms, Manfred Glados, Petra Krabisch, Esther Heck, Angelika Ober, Petra Lorenz, Kurt Diebold, Jörg-Olaf Habeck, Sibylle Loibl
Journal: Clinical Cancer Research (2016)

Abstract Purpose: We elucidated the value of tumor-infiltrating lymphocytes (TIL) as an independent predictor for pathologic complete response (pCR) rate and as a prognostic marker for disease-free survival (DFS) in patients with HER2-positive breast cancer in the neoadjuvant setting. Experimental Design: We evaluated stromal TILs in 498 HER2-positive breast cancer samples of the neoadjuvant GeparQuattro (G4) and GeparQuinto (G5) trials. Levels of TILs were determined as a continuous parameter per 10% increase and as lymphocyte-predominant breast cancer (LPBC; ≥ 60% TILs), and correlated with pCR rate and DFS. Results: In the complete cohort, HER2-positive LPBC cases had a significantly increased pCR rates compared with non-LPBC types. They were significant predictors for pCR in univariate (10% TILs: OR 1.12, P = 0.002; LPBC: OR 2.02, P = 0.002) and multivariate analyses (10% TILs: OR 1.1, P = 0.014; LPBC: OR 1.87, P = 0.009). This effect was also detectable in the trastuzumab-treated (10% TILs: OR 1.12, P = 0.018; LPBC: OR 2.08, P = 0.013) but not in the lapatinib-treated subgroup. We identified a low-risk (pCR/LPBC) and a high-risk group (no pCR/no LPBC) regarding DFS. In triple-positive breast cancer, TILs are of more prognostic relevance than pCR. Conclusions: We could demonstrate the predictive and prognostic impact of TILs in HER2-positive breast cancer in the neoadjuvant setting. In combination with pCR rate, TILs may help to stratify prognostic subgroups, thereby guiding future therapy decisions. Clin Cancer Res; 22(23); 5747–54. ©2016 AACR.
Pulmonary function tests, interstitial lung disease and lung function decline in outpatients with classic and clinically amyopathic dermatomyositis
Authors: M.D. George, R. Shah, M. Kreider, W.T. Miller, P.A. Merkel, V.P. Werth
Journal: British Journal of Dermatology (2016)

Interstitial lung disease (ILD) is common among patients with both classic dermatomyositis (DM) and clinically amyopathic dermatomyositis (CADM), patients with classic skin manifestations without weakness. ILD prognosis is thought to be worse in patients with CADM, but this observation may be due primarily to an increased frequency of rapidly-progressive ILD.

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Prognostic Value Of Quantifying Circulating Plasma Cells By Multiparametric Flow Cytometry In Patients With Relapsed Multiple Myeloma
Authors: Wilson I Gonsalves, Vinay Gupta, S. Vincent Rajkumar, William G Morice, Michael M Timm, Preet Paul Singh, Morie A Gertz, Francis K Buadi, Martha Q Lacy, Prashant Kapoor, Angela Dispenzieri, Shaji K Kumar
Journal: Blood (2013)
The So-Called "Pancreatic Reaction" in the Urine
Authors: Chas. E. Ham, J. B. Cleland
Journal: BMJ (1904)

Human respiratory syncytial virus (hRSV) is the leading cause of severe lower respiratory tract infections in children. The development of novel prophylactic and therapeutic antiviral drugs against hRSV is imperative to control the burden of disease in the susceptible population. In this study, we examined the effects of inducing the activity of the host enzyme heme oxygenase-1 (HO-1) on hRSV replication and pathogenesis on lung inflammation induced by this virus. Our results show that after hRSV infection, HO-1 induction with metalloporphyrin cobalt protoporphyrin IX significantly reduces the loss of body weight due to hRSV-induced disease. Further, HO-1 induction also decreased viral replication and lung inflammation, as evidenced by a reduced neutrophil infiltration into the airways, with diminished cytokine and chemokine production and reduced T cell function. Concomitantly, upon cobalt protoporphyrin IX treatment, there is a significant upregulation in the production of IFN-α/β mRNAs in the lungs. Furthermore, similar antiviral and protective effects occur by inducing the expression of human HO-1 in MHC class II<sup>+</sup> cells in transgenic mice. Finally, in vitro data suggest that HO-1 induction can modulate the susceptibility of cells, especially the airway epithelial cells, to hRSV infection.
Abstract P3-07-43: DNA methylation patterns correlating with outcome in patients treated with first-line bevacizumab for metastatic breast cancer
Authors: SP Gampenrieder, G Rinnerthaler, A Weinhäusel, W Pulverer, C Hugnagl, H Hackl, F Romeder, C Monzo Fuentes, C Hauser-Kronberger, B Mlineritsch, R Greil
Journal: Cancer Research (2016)

Abstract Background: Biomarkers predicting response to bevacizumab containing therapy in breast cancer are of urgent need for a personalized treatment approach. DNA methylation is involved in regulation of angiogenesis and development of treatment resistance and could therefore provide predictive information for bevacizumab efficacy. Patients and methods: A genome-wide methylation profiling using the Illumina Infinium HumanMethylation450 BeadChip was performed in FFPE specimen of 36 patients with HER2-negative metastatic breast cancer treated with chemotherapy in combination with bevacizumab as first-line therapy (discovery set). Twenty-eight (78%) samples came from primary tumor and 8 (22%) from metastasis (2 lung mets., 1 pleural met., 1 liver met., 2 soft tissue mets., 1 ovarial met, 1 bone marrow infiltration). Based on progression-free survival (PFS) and breast cancer subtype (ER+ vs. triple-negative) patients were divided in responder (R) and non-responder (NR). By biostatistical methods differences in the methylation pattern between R and NR were detected. The 48 most interesting genes (e.g. because of there involvement in angiogenesis or carcinogenesis) showing a differential methylation status between R and NR are currently validated in two further metastatic breast cancer cohorts treated with (main set) and without bevacizumab (validation set), respectively. These validated results will be presented at the meeting. Citation Format: Gampenrieder SP, Rinnerthaler G, Weinhäusel A, Pulverer W, Hugnagl C, Hackl H, Romeder F, Monzo Fuentes C, Hauser-Kronberger C, Mlineritsch B, Greil R. DNA methylation patterns correlating with outcome in patients treated with first-line bevacizumab for metastatic breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-07-43.
375PD A validation study of a new point-of-care nerve conduction device for the quantitative assesment of chemotherapy-induced peripheral neurotoxicity
Authors: A. Matsuoka, A. Mitsuma, O. Maeda, K. Uehara, T. Kikumori, H. Kajiyama, H. Kiyoi, Y. Kodera, Y. Ando
Journal: Annals of Oncology (2015)
Abstract B16: NR5A2 as a potential therapeutic target for hepatoblastoma
Authors: Jingling Jin, Roma Patel, Nan Ge Jin, Yan Shi, Wenjing Sun, Jianhua Yang, Jed G. Nuchtern, Sanjeev A. Vasudevan
Journal: Cancer Research (2016)

Abstract Hepatoblastoma (HB) is the most common malignant liver tumor in very young children. Because of multidrug resistance and severe side effects of anti-HB drugs during HB chemotherapy, it is urgent and important to develop new effective therapeutic agents with less toxicity for the treatment of pediatric patients with liver cancer. Nuclear Receptor Subfamily 5 Group A Member 2 (NR5A2; LRH-1) has been linked to various types of malignancies, and it is an emerging therapeutic target for many cancers. However the role of NR5A2 in liver cancer remains elusive. In this study, we found that both mRNA and protein expression levels of NR5A2 were significantly higher in HepG2 and HuH6 human HB cell lines and mouse orthotopic HB liver than the normal liver cell and normal liver tissue. Lentiviral-Mediated Short Hairpin RNA (shRNA) knockdown of NR5A2 inhibited HepG2 and HuH6 cell proliferation and colony formation compared with control cells. Furthermore, we found that silencing of NR5A2 induced downregulation of cell cycle gene CCND1 and the regulator gene c-myc. Similar to the effects of shRNA, we found the NR5A2 antagonist treatment also inhibited the proliferation of human HB cell lines (HepG2, HuH6 and HepT1 cells), reduced colony formation and CCND1 and c-Myc expression. Finally, flow cytometry results showed that the NR5A2 antagonist treatment induced a decreased percentage of cells in S phase which resulted in a significant decrease in the rate of cell proliferation and tumorigenicity, and induced an increased number of cells in the G2/M phase, leading to HB cell cycle arrest at G2/M phase. Collectively, our results suggest that NR5A2 play an important role in HB cancer cell proliferation. Interference of NR5A2 by shRNA or the NR5A2 antagonist inhibits HB cell proliferation and colony formation by inhibiting the cell cycle process through downregulation of CCND1 and c-Myc expression. By targeting NR5A2 signaling pathway, NR5A2 antagonist has promising therapeutic potential in the treatment of HB cancer. Note: This abstract was not presented at the conference. Citation Format: Jingling Jin, Roma Patel, Nan Ge Jin, Yan Shi, Wenjing Sun, Jianhua Yang, Jed G. Nuchtern, Sanjeev A. Vasudevan. NR5A2 as a potential therapeutic target for hepatoblastoma. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; 2015 Nov 9-12; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(5 Suppl):Abstract nr B16.
Clinical Applications of Biomaterials
Authors: M Giudice, G Colella, A Marra
Journal: JAMA (1983)

The more and more availability of new alloplastic materials in oral and maxillo-facial reconstructions causes the necessity of judging if the biomaterials satisfy the surgical needs. The authors re-examine the main chemical, physical and biological characteristics of following materials: hydroxylapatite, polytetrafluoroethylene, polyglactin 910, polyfluorocarbons, polypropylene and report their experiences.
A quarterly update on food- and waterborne diseases in Europe - summary of data for the third quarter of 2007
Authors: J Denny, G Hernández Pezzi, J Threlfall, T Westrell, I Fisher
Journal: Eurosurveillance (2008)

This paper highlights findings from the first quarterly report on food- and waterborne diseases produced by the European Centre for Disease Prevention and Control (ECDC). In the past such reports had been generated by Enter-net, a Europe-based international surveillance network for the enteric infections. The quarterly reports are an important surveillance tool for the network participants and other public health professionals to use in order to identify emerging trends and changes taking place in a shorter interval than one year.
Treatment Options for Veterans With Posttraumatic Stress Disorder—Reply
Authors: Maria M. Steenkamp
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
An Infectious cDNA Clone of Zika Virus to Study Viral Virulence, Mosquito Transmission, and Antiviral Inhibitors
Authors: Chao Shan, Xuping Xie, Antonio E. Muruato, Shannan L. Rossi, Christopher M. Roundy, Sasha R. Azar, Yujiao Yang, Robert B. Tesh, Nigel Bourne, Alan D. Barrett, Nikos Vasilakis, Scott C. Weaver, Pei-Yong Shi
Journal: Cell Host & Microbe (2016)
Insulin Detemir Offers Improved Glycemic Control Compared With NPH Insulin in People With Type 1 Diabetes
Authors: Wieland Kiess, Klemens Raile, Angela Galler, Thomas Kapellen
Journal: Diabetes Care (2004)

The article by Home et al. (1) in the May issue of Diabetes Care prompted us to respond and comment on the current practice of reporting on clinical trials when insulin analogs are concerned. While a cure for type 1 diabetes has not yet been achieved, comprehensive, multidisciplinary treatment strategies have lead the way to offer patients and their families a near-normal life and affected children a near-normal life expectancy. Multiple injections, insulin pump therapy, and frequent blood glucose measurements have provided the basis for better quality of life and good metabolic control in people with type 1 diabetes. However, the value of insulin analogs is still in question (2). There is no doubt that industry has invested vast resources to develop new insulin types for safety and efficacy reasons. …