tbuckley/cabot-search huggingface dataset:
SAT0437 Chronic multi-site pain and quality of life among the female tea factory workers in southern sri lanka
Authors: P.V. De Silva
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Currently Ceylon tea is a major foreign exchange earner in Sri Lanka, only second to the foreign exchange earned by the garment industry. Tea industry has a large work force since it utilize manual labor for the major steps of its production. Estate population in Sri Lanka is relatively less educated and belongs to the lower socio-economic status compared to the general public. Most of the workers in tea factories are females and it has been reported that these females are commonly complaining musculoskeletal pain in multiple sites of the body. This was found to increase the work disability [1]. However this problem and its impact on quality of life have not been studied systematically. <h3>Objectives</h3> This research was carried out to study the multi-site pain and its impact on quality of life among the female tea factory workers in southern Sri Lanka. <h3>Methods</h3> This study was carried out among a random sample of female workers, working in tea factories in Akuressa division in southern Sri Lanka. Pain in two or more sites of the body for a minimum period of three months during the last 12 months was considered as chronic multi-site pain. Translated and validated WHO Quality of Life- Brief questionnaire was used to assess the quality of life of workers. Data was collected by medically qualified research assistants using a structured questionnaire. <h3>Results</h3> Four hundred female workers participated in the study. Mean age of workers was 38.25 years with the range of 19 years to 57 years. Most (61.5%) had an education only up to grade 5. Mean duration of work in tea factories is 15.55. 35.25% of workers were found to have multi-site pain. Only 25.50% rated their overall quality of life as very good or good, and 22.25% were satisfied with their health. Workers with multi-site pain were had significantly (p&lt;0.05) lower scores (worse) relating to psychological and physiological domains compared to the workers without multi-site pain. <h3>Conclusions</h3> More than one third of Female tea factory workers in Sri Lanka report chronic multi-site pain and they had lower quality of life compared to the other workers. Long term follow up studies for identify the risk factors of developing multi-site pain of these workers is therefore warranted. <h3>References</h3> Neupane S, Miranda H, Virtanen P, Siukolal A, Nygard CH. Multi-site pain and work ability among an industrial population, Occupational Medicine 2011:61(8):563-569. <h3>Disclosure of Interest</h3> None Declared
868 LIVER X RECEPTOR a-MEDIATED LIPOGENESIS INDUCED BY HEPATITIS C VIRUS NS5A AND CORE PROTEINS REGULATES VIRAL REPLICATION IN AN IN VITRO MODEL
Authors: S. Pisonero-Vaquero, M.V. García-Mediavilla, F. Jorquera, P.L. Majano, J. Gonzalez-Gallego, S. Sánchez-Campos
Journal: Journal of Hepatology (2012)
PWE-407 Scottish surgical boot camp: an induction to a community of practice
Authors: J Cleland, M Gale, L Nicol, M Hogg, A Watson, K Walker
Journal: Gut (2015)

<h3>Introduction</h3> A reduction in hours of “apprentice style” training, has led to increased interest in alternative pedagogic paradigms. Intensive “Boot Camps” have been found to accelerate the acquisition of key surgical skills.<sup>1</sup>A 4 day residential Scottish Surgical Boot Camp in the Inverness Clinical Skills Centre is now adopted by 2 Royal Colleges and recommended for 1<sup>st</sup>year Core Surgical Trainees in Scotland. It is simulation-rich and includes technical and non-technical skills, e.g. wet labs, simulated ward rounds, etc. Evaluation of other Boot Camp models have been from the quantitative perspective of efficacy of training,<sup>2</sup>usually limited to Kirkpatrick levels 1 and 2. We take a qualitative perspective to explore the development and delivery of this Boot Camp. <h3>Method</h3> Grounded in social constructivism and consistent with the theoretical lens of cultural-historical activity theory,<sup>3</sup>we used a rapid ethnographic approach<sup>4</sup>involving observations, semi-structured formal interviews with faculty and field interviews with students and faculty to understand the relationships and processes of the SSBC. <h3>Results</h3> Kirkpatrick level one feedback was positive. Further, our empirical data showed the important factors shaping the design, aims, objectives, development and positioning of SSBC within national training programmes, and a surgical community of practice. Interviews with faculty provided a picture of how the content of SSBC had changed over time in response to the trainee needs, curricular changes and growing faculty expertise. Within the SSBC, there were clear rules and expectations, division of labour, and social and skills-focused learning objectives. <h3>Conclusion</h3> This theory-grounded case study gives a unique insight into the complexity of interacting influences shaping a Boot Camp, which we believe enables a better description and understanding of the SSBC. Further data illustrating the usefulness of CHAT as a means of developing and evaluating this educational activity will be presented on the day. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Cohen ER, Barsuk JH, Moazed F, Caprio T, Didwania A, McGaghie WC. Making July Safer: Simulation-Based Mastery Learning During Intern Boot Camp. Acad Med. 2013;88:233–239 Parent RJ, Plerhoples TA, Long EE, <i>et al</i>. Early, intermediate, and late effects of a surgical skills “Boot Camp” on an objective structured assessment of technical skills: a randomized controlled study. J Am Coll Surg. 2010;210: 984–989 Engestrom Y, Miettinen R, Punamaki R. Activity Theory and Individual and Social Transformation. Perspectives on Activity Theory. Cambridge: Cambridge University Press 1999 Savage J. Ethnography and healthcare. BMJ 2000;321:1400
Inactivating Mutations in the 25-Hydroxyvitamin D<sub>3</sub>1α-Hydroxylase Gene in Patients with Pseudovitamin D–Deficiency Rickets
Authors: Sachiko Kitanaka, Ken-ichi Takeyama, Akiko Murayama, Takashi Sato, Katsuzumi Okumura, Masahiro Nogami, Yukihiro Hasegawa, Hiroo Niimi, Junn Yanagisawa, Toshiaki Tanaka, Shigeaki Kato
Journal: New England Journal of Medicine (1998)

Pseudovitamin D–deficiency rickets is characterized by the early onset of rickets with hypocalcemia and is thought to be caused by a deficit in renal 25-hydroxyvitamin D3 1α-hydroxylase, the key enzyme for the synthesis of 1α,25-dihydroxyvitamin D3.
IL-21 induces socs-mediated suppression of TLR triggering but aggravates TH17-driven destructive arthritis
Authors: Renoud J Marijnissen, Marije I Koenders, Shahla Abdollahi-Roodsaz, Cheryl Nickerson-Nutter, Fons A J van de Loo, Annemieke M H Boots, Wim B van den Berg
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background and objective</h3> IL-21 is an immune-regulatory cytokine that can have both proinflammatory and immunosuppressive effects. The purpose of this study was to investigate the potential dual role of IL-21 in experimental arthritis. <h3>Material and methods</h3> For in vitro studies, freshly isolated C57Bl6 splenocytes were stimulated with TLR2/NOD2-binding ligands in the presence or absence of IL-21. In addition, chronic Streptococcal cell wall (SCW) arthritis and antigen-induced arthritis (AIA) were induced in IL-21-receptor-deficient (IL-21R-/-) mice and wild-type (WT) controls. <h3>Results</h3> In vitro stimulation of splenocytes with TLR2/NOD2-binding SCW fragments resulted in enhanced production of IL-6 and CXCL1, but not IL-10. Interestingly, this proinflammatory response was blocked in the presence of IL-21. QPCR analysis demonstrated that IL-21 strongly induced SOCS expression, suggesting a SOCS-dependent immunosuppressive effect of IL-21 on TLR signaling. In contrast, at first sight our in vivo studies using IL-21R-deficient mice showed a proinflammatory role of IL-21 in experimental arthritis. In both SCW-induced arthritis and AIA, IL-21R-deficiency protected against severe joint inflammation and destruction. This reduced pathology in IL-21R-/- mice was accompanied by suppressed antigen-specific T cell responses, decreased serum IgG1 levels, reduced IL-17 levels in joint lavage, and lower numbers of IL-17+ IFNγ+T cells in the joint. However, during every local (re)challenge of SCW arthritis with TLR ligands, a clearly enhanced joint swelling was found in IL-21R-deficient mice. No differences were found in the expression of TLR2 and NOD2, the most important receptors for SCW. However, while the WT showed a massive upregulation of SOCS1/3 at day 4 of arthritis, IL-21R-/- mice were significantly less capable in upregulating these genes. These data suggest that impaired SOCS regulation in the absence of IL-21 signaling contributes to the increased local activation during SCW arthritis. <h3>Conclusion</h3> Despite the proinflammatory role of IL-21 in adaptive immunity, driving IL-17/IFNγ double-positive cells and joint pathology during chronic experimental arthritis, IL-21 also has an important immunosuppressive role in innate immunity by inhibiting TLR signaling via SOCS1/3. This dual role of IL-21 in various immune processes makes IL-21 a difficult therapeutic target in RA.
Abstract 2041: Her2/Neu has an essential role for the gamma-irradiation-induced ERK1/2 signaling activation and G2/M checkpoint response
Authors: Ying Yan, Patrick M. Greer, Ryan H. Kolb, Kenneth H. Cowan
Journal: Cancer Research (2012)

Abstract Gamma-irradiation (IR)-induced double strand DNA breaks frequently results in G2/M cell cycle arrest, allowing time for DNA repair prior to re-entering cell cycle. Previous studies from our laboratory have shown that the G2/M checkpoint activation following exposure of MCF-7 breast cancer cells to IR is dependent on the activation of extracellular signal-regulated protein kinase 1 and 2 (ERK1/2) signaling. Studies presented in this report indicate that IR exposure of several breast cancer cell lines (MCF-7, MDA-MB-231, SKBR3 and T47D) is associated with a marked increase in HER2/neu phosphorylation and that the inhibition of HER2/neu using specific inhibitors abrogates the IR-induced activation of both MEK1/2 and ERK1/2 in these cells. Furthermore, the HER2/neu inhibition also results in attenuation of IR-induced G2/M arrest and concomitant diminution of IR-induced activation of ATM, ATR, Chk1 and Chk2 kinases. In contrast, inhibition of HER1/EGFR using specific inhibitors has no detectable effect on IR-induced increase of ERK1/2 phosphorylation as well as the induction of G2/M arrest following IR exposure. Collectively, results in this report suggest that HER2/neu plays an essential role in the activation of IR-induced of MEK/ERK signaling and subsequent G2/M checkpoint response. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2041. doi:1538-7445.AM2012-2041
Allopurinol in the Treatment of American Cutaneous Leishmaniasis
Authors: Samuel Martinez, J. Joseph Marr
Journal: New England Journal of Medicine (1992)

Pentavalent antimony, the generally accepted treatment for leishmaniasis, is given parenterally, and it is expensive and not readily available In developing countries. An inexpensive, orally administered compound would be a substantial advance in treatment. Previous studies in vitro have shown synergism between allopurinol and pentavalent antimony in tissue-culture systems. We designed this clinical study to determine whether synergism could be demonstrated In patients.
A2
Authors: Stephen R. Bunker, William P. Schmidt, Michael F. Hartshorne, William H. Howard, John M. Bauman, Michael A. Cawthon, Robert D. Karl
Journal: Clinical Nuclear Medicine (1984)

Bunker, Stephen R.; Schmidt, William P.; Hartshorne, Michael F.; Howard, William H. III; Bauman, John M.; Cawthon, Michael A.; Karl, Robert D. Jr. Author Information
379 THREE PHENOTYPICALLY AND FUNCTIONALLY DISTINCT MONOCYTE SUBSETS AND THEIR ROLE IN HUMAN LIVER FIBROSIS
Authors: E. Liaskou, H. Zimmermann, S.S. Choi, O. Qureshi, Z. Stamataki, J. Shaw, S.M. Curbishley, W.-K. Syn, D.H. Adams
Journal: Journal of Hepatology (2012)
Case 39-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Walter J. Koroshetz, Ann C. McKee
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 76-year-old man was admitted to the hospital because of confusion and agitation.He was well and active until 14 weeks earlier, when his wife noticed that he became forgetful and confused, especially at night, shortly after the death of his brother. He was admitted to another hospital but soon became combative and was transferred to a second hospital. A cranial computed tomographic (CT) scan, performed before and after the intravenous injection of contrast material, showed moderate enlargement of the lateral ventricles and sulci; the body of the left lateral ventricle was larger than the right ventricle; . . .
Pain Control Recommendations Released
Authors: J. A. Steele
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Pain Control Recommendations Released Get access Julie A. Steele Julie A. Steele Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 18, 18 September 1991, Page 1284, https://doi.org/10.1093/jnci/83.18.1284 Published: 18 September 1991
Effects of Saline, Mannitol, and Furosemide on Acute Decreases in Renal Function Induced by Radiocontrast Agents
Authors: Richard Solomon, Craig Werner, Denise Mann, John D'Elia, Patricio Silva
Journal: New England Journal of Medicine (1994)

Injections of radiocontrast agents are a frequent cause of acute decreases in renal function, occurring most often in patients with chronic renal insufficiency and diabetes mellitus.
Abstract 2256: Identifying the molecular signature of melanoma metastasis via a personalized quantitative proteomics approach
Authors: Azza Eissa, Chan-Kyung J. Cho, Eleftherios P.D. Diamandis
Journal: Cancer Research (2010)

Abstract Melanoma metastasis is the primary cause of skin cancer deaths. Unfortunately, the biology of melanoma metastasis remains elusive, although several pathways, including epithelial-to-mesenchymal transition (EMT), have been suggested as underlying mechanisms of tumor progression and immunosuppression. No reliable single or multiple prognostic markers currently exist in the clinic to predict chances of melanoma metastasis, resistance to therapy, and recurrence after treatment. Microarrays have been the primary means for large-scale expression analyses of genes implicated in cancer progression. However, recent advents in high throughput mass spectrometry allow for investigating cancer development directly at the protein level. In this study, we applied a quantitative proteomics technique, Stable Isotope Labeling with Amino acids in Cell culture (SILAC), to compare the proteomes of primary and metastatic cancer cells derived from the same melanoma patient. We hypothesized that quantitative proteomic profiling of primary and metastatic cell lines from the same patient will: 1) reflect differences in their metastatic potential by identifying differentially expressed proteins and pathways, 2) uncover new protein candidates involved in cancer progression-related processes, such as EMT, and 3) yield promising prognostic biomarkers and therapuetic targets. A “bottom-up” proteomics approach and a two-dimensional (strong cation exchange followed by reversed-phase) LC-MS/MS strategy on an LTQ-Orbitrap were utilized to perform 3 different pair-wise comparisons of the expressions of extracellular and membrane-bound proteins in the conditioned media of melanoma cell lines from 3 different patients (3 primary cells labelled with ‘light’ arginine and lysine and their corresponding ‘heavy’- labelled metastatic counterparts). We identified over 1000 proteins from each pair of primary and metastatic cell conditioned media, several of which were previously reported as either up-regulated or down-regulated in melanoma, confirming the validity of our approach. In addition, we identified candidate proteins that have not been correlated previously with melanoma metastasis. Candidate proteins were selected based on the quantification ratio (&amp;gt;2-fold change) between the two conditions and the consistency among triplicates within each condition. Many of the identified proteins may shed light on the molecular mechanisms underlying melanoma metastasis and may open novel areas for further research geared towards finding effective personalized prognostic and therapeutic approaches to manage this devastating cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2256.
OC-055 A Novel Technique for full Thickness Laparoendoscopic Excision of Colonic Lesions: an Experimental Pilot Study
Authors: A Brigic, A Southgate, P D Sibbons, C Fraser, S K Clark, R H Kennedy
Journal: Gut (2013)

<h3>Introduction</h3> Introduction of a National Bowel Cancer Screening Program in England has resulted in an increasing number of patients diagnosed with endoscopically irresectable colonic polyps. A significant proportion of these patients is referred for hemicolectomy and is subject to a significant risk of morbidity and mortality. Therefore, a less invasive treatment option is required and to address this, we modified a previously reported full thickness laparo-endoscopic excision (FLEX) technique. <h3>Methods</h3> Surgery was performed in five 70-kg pigs. A simulated colonic polyp was created by endoscopic injection of Spot® and the clearance margin delineated by circumferential placement of mucosal argon plasma coagulator (APC) marks. Full thickness eversion of the colonic wall, including the lesion, was achieved by endoscopic placement of prototype BraceBars (BBs). The everted section was excised using a linear laparoscopic stapler placed below the BBs. The first pig was terminated immediately and others were sacrificed 8 days after surgery. <h3>Results</h3> The median procedure duration, defined from placement of mucosal APC marks to specimen excision, was 26 min (range 20–31 min). All excised specimens contained three pairs of BBs, included the APC marks and had a median diameter of 5.1 cm (range 4.5–6.3 cm). Postoperative recovery in survival animals was uneventful. Post-mortem evaluation demonstrated well-healed resection sites with no evidence of intra-abdominal infection or inadvertent organ damage. Endoscopic evaluation of anastomoses at post-mortem demonstrated a widely patent lumen without evidence of stenosis at excision sites. Histological examination of the anastomoses showed primary closure by mucosal abbutal and regeneration, with repair and restoration of submucosal continuity. <h3>Conclusion</h3> This proof-of-concept study has demonstrated the feasibility and safety of a novel full thickness colonic excision technique that is now ready for translation as an alternative to hemicolectomy. The excision size will accommodate most colonic polyps that currently come to surgery. Accurate placement of endoscopic BBs ensures complete excision, reducing the risk of residual disease and recurrence, while laparoscopic overview avoids collateral damage. The ability to preserve mesenteric vasculature and colonic length is likely to result in less morbidity and mortality, better functional outcomes and the approach should reduce treatment costs. <h3>Disclosure of Interest</h3> None Declared
PTH-085 Monoclonal Antibody Therapy in Crohn’S Disease: Does Serial Faecal Calprotectin Play a Role?: Abstract PTH-085 Table 1
Authors: A A Thi, P BASUMANI, M Walsh, M Jerrison, K D Bardhan
Journal: Gut (2013)

<h3>Introduction Background</h3> Mucosal healing (MH) is an increasingly important therapeutic goal in inflammatory bowel disease. Monoclonal antibody (MA) therapy aims to achieve this and faecal calprotectin (FC) concentration has been shown as a surrogate marker for MH. <h3>Aims</h3> Our aim was to study the profile of Crohn’s disease (CD) patients on MA therapy and evaluate whether FC levels after induction therapy with MA predicts the medium-term outcome. <h3>Methods</h3> Thirty-two CD patients: infliximab n = 11, adalimumab n = 21 were identified from our MA database. Data on demography and disease characteristics were extracted from case records. A subset of CD patients with FC levels measured both at baseline and after induction therapy were analysed further for response to therapy and disease course during follow-up (n = 10). Disease activity was evaluated by modified Harvey-Bradshaw index at baseline, after induction, and at 6 and 12 months during maintenance therapy. <h3>Results</h3> Of 32 patients, 22 patients were female, medium age 39.5 (range: 19–65 year), medium age at diagnosis 30.2 (range: 16–61year), mean disease duration prior to MA was 6.1 (range: 10 –22 year) and 21.8% has family history of inflammatory bowel disease. Of these, 56.2% had history of surgery prior to MA and 71.7% had concurrent immunomodulation. Disease phenotypes are shown in table. Of the 10 patients with full FC data, 6 patients normalised FC after induction (median levels 67 mg/kg, median 64 mg/ks, range 30–72). All remained in remission during follow-up median- 22 months (range 13–33 months). Four patients failed to normalise FC levels with induction therapy (median 11 months, range 6–39). Of these, 2 had operation, 2 had multiple relapses (1 treated with prolonged enteral therapy and 1 with additional oral corticosteroid courses). <h3>Conclusion</h3> MA therapy is used in CD patients with aggressive disease course who are treated/intolerant to immunomodulatory therapy. Normalisation of FC after induction therapy with MA is a useful marker to predict sustained clinical remission. <h3>Disclosure of Interest</h3> None Declared.
Breast Metastasis of Non-Hodgkin’s Lymphoma
Authors: YUKIHIRO HAMA, SHIGERU KOSUDA, MINORU UEMATSU, SHOICHI KUSANO
Journal: Clinical Nuclear Medicine (2000)

Malignant lymphoma that secondarily involves the breast is uncommon. The authors describe the Ga-67 scintigraphic findings of two patients with metastatic non-Hodgkin’s lymphoma in the breast that was histopathologically proved by mastectomy or excisional biopsy.