tbuckley/cabot-search huggingface dataset:
FRI0493 Clinical Features of The Vogt-Koyanagi-Harada Syndrome
Authors: J. Losanto, N. Colman, M. Duarte
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Vogt-Koyanagi-Harada9s disease (VKHD) is a bilateral, diffuse and chronic granulomatous panuveitis characterized by serous retinal detachment. This disease is often associated with neurological, auditory and dermatological disorders. The incidence of appearance is low, affecting mainly young women between 30 years approximately. <h3>Objectives</h3> The objective of the present study was to describe and to analyze the characteristics of patients with VKHD, followed in a third level hospital. <h3>Methods</h3> Retrospective and descriptive study of patients with EVKH. A large number of clinical, epidemiological variables and treatment were recorded. Statistical analysis was performed with SPSS19.0 program. The qualitative variables were expressed as frequencies and percentages, quantitative variables in mean. <h3>Results</h3> In the last 5 years, 3727 clinical records were reviewed and 8 patients were included. Of these, 5 (62.5%) were women with a mean age at diagnosis of 43 years old. All patients referred decreased visual acuity, 100% with bilateral panuveitis and 75% were associated with serous retinal detachment. Dermatological disorders was found in 25% (i.e. vitiligo, poliosis and alopecia), neurosensorial hearing loss in 25% and 12.5% of patients presented asthenia and fever. Neurological symptoms (ie epilepsy, meningismus, confusion, impaired balance) were found in 37.5%. About treatment, all patients received high doses of systemic glucocorticoids and 25% also received non-steroidal anti-inflammatory drugs (NSAIDs). 37.5% of patients received cyclophosphamide, 62.5% azathioprine and 12.5% methotrexate. Visual acuity improved in 75% of cases. Ocular complications were seen in 50% of patients, 12.5% with cataracts, 25% synechiae and glaucoma and band keratopathy in 12.5%. No patients required vitrectomy, nor developed ocular hypertension. Currently only 1 patient has active disease. <h3>Conclusions</h3> In our series of VKHD patients, we found that all required immunosuppressive therapy due to the severity of the disease and with this aggressive treatment, the prognosis of this disease was favorable. <h3>Acknowledgement</h3> Dra Gabriela Avila. <h3>Disclosure of Interest</h3> None declared
OP0137 Diabetes Prevalence in Patients with Juvenile Idiopathic Arthritis (JIA)
Authors: S. Schenck, R.W. Holl, M. Niewerth, J. Klotsche, K. Minden, J. Rosenbauer, A. Thon
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The majority of JIA categories are considered as autoimmune diseases. Autoimmune diseases seem to cluster in children and adolescents with JIA, which is attributed to shared susceptibility genes. Studies revealed an increase in the simultaneous JIA and juvenile type 1 diabetes mellitus (T1D) occurrence and an increased JIA prevalence in patients with T1D [1]. However, the frequency of T1D in JIA patients in comparison to the general population is unknown. <h3>Objectives</h3> To determine the frequency of T1D in JIA patients and to characterize patients having both JIA and T1D. <h3>Methods</h3> Diabetes comorbidity was recorded in the national paediatric rheumatologic database (NPRD) in 2012 and 2013. Data of the North Rhine-Westphalian diabetes register and the Diabetes data acquisition system for prospective surveillance (DPV) served as reference for the diabetes prevalence in the general population. NPRD data were indirectly standardized for age and sex for the comparison with the general population. The diabetes prevalence ratio (PR) was calculated using Poisson regression models. <h3>Results</h3> 9,359 JIA patients were included in the analyses. Patient mean age was 12 years (SD 4.5), mean disease duration 4.5 years (SD 3.8). 50 patients had T1D in addition to JIA, diabetes prevalence was 0.5%. Patients with versus without T1D did not differ significantly in the JIA category spectrum. Compared to the general population, the diabetes prevalence in JIA patients was significantly increased (PR: 1.96 [CI: 1.49;2.59], p&lt;0.001). The PR for diabetes for girls was 1.92 (CI: 1.35;2.73, p&lt;0.001) and for boys 2.04 (CI: 1.30;3.19, p=0.002). Diabetes onset in JIA patients was slightly earlier than in the age- and sex-matched population. More than half of the patients (58%) developed diabetes before JIA. Diabetes onset was on average 60 months before the JIA onset. Patients with JIA before T1D developed T1D on average 35 months after JIA onset. The majority of these patients had not received any DMARDs before diabetes onset. <h3>Conclusions</h3> Diabetes type 1 occurs more frequently in JIA patients than in the general population. The likelihood of T1D seems to be slightly higher before JIA manifestation and in patients who were not treated with DMARDs after JIA onset. The NPRD has been funded by the German Children Arthritis Foundation (Deutsche Kinder-Rheumastiftung). <h3>References</h3> Hermann G, Thon A, Mönkemoller K, Lilienthal E, Klinkert C, Holder M et al. Comorbidity of type 1 diabetes and juvenile idiopathic arthritis. J Pediatr 2015;166:930–5. <h3>Disclosure of Interest</h3> None declared
MLL-AF6 Mediated Transformation Is Dependent On the H3K79 Methyl-transferase Dot1l
Authors: Aniruddha J Deshpande, Liying Chen, Maurizio Fazio, Amit U. Sinha, Kathrin M Bernt, Deepti Banka, Stuart Dias, Edward J Olhava, Scott R Daigle, Victoria M Richon, Roy M Pollock, Scott A. Armstrong
Journal: Blood (2012)
Abnormal gene expression can be linked to chromosomal gains and losses in paediatric astrocytoma
Authors: N. Potter, R. Poh, Samantha Ward, Kim Phipps, Richard Hayward, William Harkness, Dominic Thompson, David G. Thomas, J. Rees, John L. Darling, Tracy Warr
Journal: Neuro-Oncology (2006)

Abstracts from Neuro-Oncology are provided here courtesy of Society for Neuro-Oncology and Duke University Press
Defibrotide (DF) In the Treatment of Severe Hepatic Veno-Occlusive Disease (VOD) with Multi-Organ Failure (MOF): Results of a Treatment IND Expanded Access Protocol
Authors: Paul Richardson, Angela Smith, Sally Arai, Stephan A. Grupp, Nancy A Kernan, Roberta Adams, Paul L Martin, Sunil Abhyankar, Alfred Gillio, Michael Grimley, Leslie E. Lehmann, Paul Haut, Amanda Termuhlen, Joseph H. Antin, Thomas Spitzer, David Avigan, Joseph Massaro, Alison L. Hannah, Massimo Iacobelli, Robert J Soiffer
Journal: Blood (2010)
The Landscape of RUNX1 Mutations in Acute Myeloid Leukemia: Investigations On Stability of Mutations At Relapse and Utility As a Marker for Minimal Residual Disease
Authors: Alexander Kohlmann, Niroshan Nadarajah, Vera Grossmann, Tamara Alpermann, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach, Susanne Schnittger
Journal: Blood (2012)
P58 Efficacy of budesonide/formoterol in COPD patients with a post-bronchodilator fev1 50 to &lt;70% of predicted normal: pooled analysis across four phase iii/iv studies
Authors: C Jorup, GD James, K Pemberton, G Eckerwall
Journal: Thorax (2016)

<h3>Background</h3> GOLD guidelines have changed from classifying COPD severity using pre-bronchodilator FEV<sub>1 </sub>to classifying severity based on post-bronchodilator FEV<sub>1.</sub> We therefore conducted a pooled <i>post-hoc</i> analysis of four budesonide/formoterol (Symbicort<sup>®</sup>) Turbuhaler<sup>®</sup> trials in COPD (which included patients based on pre-bronchodilator FEV<sub>1</sub>), assessing efficacy and safety of budesonide/formoterol in the post-bronchodilator FEV<sub>1</sub>50– &lt;70% of predicted normal (PN) subpopulation versus the all-patient population. This analysis supported the EU label change for Symbicort<sup>®</sup> Turbuhaler<sup>®</sup> to: ‘symptomatic treatment of patients with COPD with FEV<sub>1</sub> &lt; 70% PN (post-bronchodilator) and an exacerbation history despite regular bronchodilator therapy’. <h3>Methods</h3> Four randomised, double-blind, active- and/or placebo-controlled, studies in patients with moderate to very severe COPD were analysed. Key study inclusion criteria were pre-bronchodilator FEV<sub>1</sub> ≤50% PN; use of short-acting bronchodilator; ≥1 exacerbation in the past 12 months. Primary endpoints for the analysis were 3-month pre- and 3- and 12-months post-bronchodilator FEV<sub>1</sub> and exacerbation rates at 3- and 12-months. Secondary endpoints included dyspnoea score, total symptom score, reliever medication use, night-time awakening and St George’s Respiratory Questionnaire. Results for the post-bronchodilator FEV<sub>1</sub>50 – &lt;70% PN subpopulation were compared with the all-patient population. <h3>Results</h3> Of 3787 randomised patients, 832 (22.0%) had post-bronchodilator FEV<sub>1</sub>50 – &lt;70% PN. Baseline characteristics of the FEV<sub>1</sub>50 – &lt;70% subpopulation and the all-patient population were similar, except for baseline FEV<sub>1</sub> parameters. The benefit of budesonide/formoterol versus placebo and formoterol on the primary and secondary endpoints were generally consistent between the FEV<sub>1</sub>50 – &lt;70% subpopulation and the all-patient population across all four studies and in the pooled analysis (Figure 1). No new safety signals were identified. <h3>Conclusions</h3> In patients with COPD, the clinical efficacy and safety of budesonide/formoterol compared with placebo and formoterol was consistent between the post-bronchodilator FEV<sub>1</sub> 50 – &lt;70% PN subpopulation and the all-patient population, confirming the positive benefit/risk ratio in COPD patients with a post-bronchodilator FEV<sub>1</sub> &lt;70% PN and a history of exacerbations.
PWE-133 Female Representation in Leadership Roles: Results from The Supporting Women in Gastroenterology (SWIG) Survey
Authors: E Arthurs, A Brooks, E Taylor, J Solomon, P Neild, S Thomas-Gibson, M Lockett, C Edwards, J Eaden
Journal: Gut (2016)

<h3>Introduction</h3> Whilst numbers are increasing, women remain under-represented at both trainee and consultant grade in gastroenterology compared with other medical specialties, 52% and 34% respectively.<sup>1</sup> There is little available data on female representation in leadership roles in gastroenterology in the UK. The aim of this survey was to identify the key issues around female representation in positions of leadership. <h3>Methods</h3> A comprehensive survey was designed and circulated to consultants and trainees in gastroenterology; all were members of the BSG. Data regarding demographics, professional experiences and opinions was collected and analysed. <h3>Results</h3> The survey was sent to 1900 people, 600 people opened the email and 186 responded, a response rate of 9.79%. 107 of respondents were female (62.9%), 16 respondents did not declare gender. Data was available for 183 responses. Of 188 responses, 119 (63.3%) of respondents had a leadership role; 66 were female (55.5%) and 52 (43.7%) were male. 48 (40.3%) had a local role within the medical school, LETB or NHS trust (29 (60.4%) female versus 18 (37.5%) male); 40 (33.6%) had one or more regional roles (23 (57.5%) female versus 17 (42.5%) male) and 31 (26.1%) had one or more national roles (14 (45.2%) female versus 17 (54.8%) male). Important reasons for not having a leadership role were time constraints due to workload at work (22.4% of responses, n = 32, 75% female versus 21.9% male (gender not declared 1)), time constraints due to home commitments (18.2% of responses, n = 26, 80.8% female versus 19.2% male) and lack of confidence (14.7% of responses, n = 21, 80.9% female versus 19.0% male). Iimportant factors to encourage people to take on a leadership role included time and flexibility at work (30.4% of responses; n = 49, 77.6% female versus 22.4% male), personal invitation (24.2%; n = 39, 82.1% female versus 17.9% male) and more opportunity (11.9%; n = 18, 77.8% female versus 22.2% male). <h3>Conclusion</h3> Whilst women hold local and regional leadership roles, they remain under-represented at nationally. Strong influencing factors that have emerged are busy work and home commitments and lack of confidence. Introducing more time and flexibility into job roles, personally inviting potential female candidates and creating more opportunities may encourage more women in the speciality to undertake leadership roles. <h3>Reference</h3> 1 Census of consultant physicians and higher speciality trainees in the UK, 2014–2015. Royal College of Physicians, 2016. <h3>Disclosure of Interest</h3> None Declared
Declining Rates of Treatment-Related Mortality in Patients with Newly Diagnosed Acute Myeloid Leukemia (AML) Given “Intensive” Induction Regimens: A Report From the Southwest Oncology Group (SWOG) and MD Anderson Cancer Center (MDA)
Authors: Megan Othus, Hagop M. Kantarjian, Stephen Petersdorf, Farhad Ravandi, Jorge E. Cortes, Sherry A. Pierce, Harry Paul Erba, Stefan Faderl, Frederick R. Appelbaum, Elihu H. Estey
Journal: Blood (2012)
Combined High Resolution Array Comparative Genomic Hybridization and Gene Expression Profiling Reveal Rb1 Haploinsufficiency as a Possibile Tumorigenic Mechanism in Myeloma.
Authors: Wee-Joo Chng, Angela Baker, Travis Henry, Tammy Price-Troska, Scott Van Wier, Tae-Hoon Chung, Kim Henderson, Gregory Ahmann, Martha Lacy, Angela Dispenzieri, Morie Abraham Gertz, Philip Greipp, Peter Leif Bergsagel, John Carpten, Rafael Fonseca
Journal: Blood (2006)
Darbepoetin Alfa (DA) - Pattern of Use and Outcomes in Adult Patients with Non-Myeloid Malignancies and Chemotherapy-Induced Anemia: A French Observational Study.
Authors: Arnaud P.M. Pigneux, Isabelle L. Ray-Coquard, Philippe J.M. Dalivoust, Gaelle Chenuc Biostat, Anne M. Bastie
Journal: Blood (2006)
Group behavior in the military may provide a unique case
Authors: Rose McDermott
Journal: Behavioral and Brain Sciences (2016)

Abstract The optimal functioning of male coalitionary behavior in a military context may run contrary to some of the arguments about the importance of individual differentiation in Baumeister et al. Incentives become institutionally inverted within military contexts. Because the history of combat exerted powerful and sustained selection pressures on male groups, individual identification can work against the successful completion of collective action problems surrounding in-group defense in military contexts.
Metabolic and Inflamatory Proteins Differently Expressed in Platelets From Deep Venous Thrombosis Patients
Authors: Mariane Cristina Flores Nascimento, Karina Kleinfelder-Fontanesi, Fernanda Loureiro de Andrade Orsi, Steven H Seeholzer, Harry Ischiropoulos, Joyce M Annichino-Bizzacchi
Journal: Blood (2011)
FRI0518 Ultrasound Definitions for Vasculitis in Cranial and Large Vessel Giant Cell Arteritis: Results of A Delphi Survey of The Omeract Ultrasound Large Vessel Vasculitis Group
Authors: C. Duftner, C. Dejaco, U. Moller Dohn, G.A. Bruyn, S. Chrysidis, M.A. D'Agostino, B. Dasgupta, E. de Miguel, A.P. Diamantopoulos, P. Hanova, W. Hartung, A. Iagnocco, T.A. Kermani, M.J. Koster, P. Macchioni, M. Milchert, C. Mukhtyar, E. Naredo, C. Ponte, N. Rastalsky, V.S. Schäfer, L. Terslev, K.J. Warrington, W.A. Schmidt
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> In a systematic literature review (SLR), we identified halo sign, stenosis, occlusion, compression sign and a decreased vessel wall pulsation as elementary ultrasound (US) lesions in giant cell arteritis (GCA). <h3>Objectives</h3> To establish consensus-based definitions for the key elementary US lesions in GCA. <h3>Methods</h3> We invited 25 rheumatologists from 13 countries experienced in musculoskeletal and vascular US to participate in a Delphi exercise. Based on the results from the SLR and international expert consensus a questionnaire was developed including 12 statements on the definitions of normal temporal and extra-cranial large arteries, arteriosclerosis, halo sign, stenosis, occlusion, compression sign, and vessel wall pulsation. The experts were asked to express their level of agreement or disagreement with the proposed statements. A consensus was defined as agreement of ≥75% of participants. <h3>Results</h3> The response rate was 24/25 (96%) in round 1 and 24/24 (100%) in round 2. A consensus was achieved for 9/9 Delphi statements [normal temporal and extra-cranial large arteries, arteriosclerosis, halo sign, stenosis of temporal and extra-cranial large arteries, occlusion, compression sign (temporal arteries), US assessment of compression sign (temporal arteries) in round 1. In round 2, 3/3 Delphi statements (arteriosclerosis, halo sign, stenosis of temporal arteries) were redefined. The statements on vessel wall pulsation (definition and assessment) and measurement of vessel wall thickness did not reach the threshold for consensus. The halo and compression signs were deemed to be the most important US signs for GCA with 100% and 83.3% expert agreement, respectively. <h3>Conclusions</h3> This is the first international consensus on definitions for elementary US lesions in GCA. The next steps of the OMERACT project will be web- and patients based exercises testing the reliability of the new definitions. <h3>Disclosure of Interest</h3> None declared
Core Elements of Outpatient Antibiotic Stewardship
Authors: Guillermo V. Sanchez, Katherine E. Fleming-Dutra, Rebecca M. Roberts, Lauri A. Hicks
Journal: MMWR Recommendations and Reports (2016)

The Core Elements of Outpatient Antibiotic Stewardship provides a framework for antibiotic stewardship for outpatient clinicians and facilities that routinely provide antibiotic treatment. This report augments existing guidance for other clinical settings. In 2014 and 2015, respectively, CDC released the Core Elements of Hospital Antibiotic Stewardship Programs and the Core Elements of Antibiotic Stewardship for Nursing Homes. Antibiotic stewardship is the effort to measure and improve how antibiotics are prescribed by clinicians and used by patients. Improving antibiotic prescribing involves implementing effective strategies to modify prescribing practices to align them with evidence-based recommendations for diagnosis and management. The four core elements of outpatient antibiotic stewardship are commitment, action for policy and practice, tracking and reporting, and education and expertise. Outpatient clinicians and facility leaders can commit to improving antibiotic prescribing and take action by implementing at least one policy or practice aimed at improving antibiotic prescribing practices. Clinicians and leaders of outpatient clinics and health care systems can track antibiotic prescribing practices and regularly report these data back to clinicians. Clinicians can provide educational resources to patients and families on appropriate antibiotic use. Finally, leaders of outpatient clinics and health systems can provide clinicians with education aimed at improving antibiotic prescribing and with access to persons with expertise in antibiotic stewardship. Establishing effective antibiotic stewardship interventions can protect patients and improve clinical outcomes in outpatient health care settings.
SAT0524 Comparison of Ultrasonography-Guided Injection with Blind Injection in Facet Syndrome; A 6-Week Randomized Controlled Trial
Authors: M. Karkucak, I. Batmaz, S. Kerimoglu, A. Ayar
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Local injection is a good alternative medical treatment in soft tissue disorders. Ultrasonography (US) is a good guide for local applications which increases the efficacy of the treatment. <h3>Objectives</h3> To compare the local injection performed by US-guided with blind injection in facet syndrome <h3>Methods</h3> Forty seven patients with the diagnosis of facet syndrome were included in the study.Patients were randomized into two groups. The patient9s history, physical examination and routine laboratory parameters were used to diagnosis of facet syndrome. Inclusion criteria for the study were as follows: pain for at least 6 weeks, pain extending to gluteal region and thigh, presence of pain with lumbar hyperextension and lateral flexion, paravertebral tenderness at the facet joint localization, negative straight leg raising test and normal neurological examination findings. Approximately 5 cc of injection solution which was a mixture of 1–2% lidocaine hydrochloride and triamcinolone was applied twice within 15 days to maximum 2 points most tender with palpation (bilateral; L4–5 or L5-S1, unilateral; L4–5 and L5-S1). Assessment was made within 0, 2 and 6 weeks with Visual analog scale (VAS), Modified Oswestry scale and State-Trait Anxiety Inventory. <h3>Results</h3> The patients9 initial VAS and Oswestry scale scores were similar. When the two groups were compared at the 6th week in terms of VAS scores, improvement was more pronounced in US-guided injection group (US-guided group before 7.6±2.2, after 3.0±1.7, p=0.000 vs blind group before 7.2±1.3, after 5.2±2.0, p=0.000). According to Oswestry scale scores at the 6th week there was no statistically significant difference between the two groups. The improvement in initial and 6th week Oswestry scale scores was statistically significant in the US-guided injection group (p=0.006). The improvement in trait anxiety scale scores was significant in both groups. <h3>Conclusions</h3> The US-guided local injections used in the treatment of facet syndrome have positive impact on both pain and functions. <h3>Disclosure of Interest</h3> None declared
Idiopathic CD4 Lymphocytopenia Due to Loss of Heterozygosity of the Mutant CD2 Gene
Authors: Masaharu Tashima, Momoko Nishikori, Toshio Kitawaki, Masakatsu Hishizawa, Taisuke Izumi, Yayoi Fujiwara, Minako Mori, Kaori Kihara, Katsuyuki Ohmori, Tadakazu Kondo, Takayuki Ishikawa, Akifumi Takaori-Kondo
Journal: Blood (2010)
Interventions that enhance health-professional contact with parents and infants to improve child development and social and emotional wellbeing in the early years in high-income countries: a systematic review
Authors: Lisa Hurt, Shantini Paranjothy, Patricia J Lucas, Debbie Watson, Mala Mann, Lucy Griffiths, Samuel Ginja, Tapio Paljarvi, Jo Williams, Mark Bellis, Raghu Lingam
Journal: The Lancet (2016)
Proteomic Characterization of Circulating Extracellular Vesicles Identifies Novel Serum Myeloma Associated Markers
Authors: David Ciarlariello, Sean Harshman, Alessandro Canella, Erinn Hade, Alberto Rocci, Antonio Palumbo, Craig C Hofmeister, Michael Freitas, Don M Benson, Flavia Pichiorri
Journal: Blood (2015)