tbuckley/cabot-search huggingface dataset:
Virtual issue: focus on cardiovascular protection
Authors: Wouter Vandevelde, Karin R. Sipido
Journal: Cardiovascular Research (2016)

In this issue of Cardiovascular Research , a collection of recently published papers is made available specifically aiming to illustrate recent advances in cardiovascular protection, a topic that is prominent at the 2016 Frontiers in Cardiovascular Biology (FCVB) meeting (http://www.escardio.org/Congresses-&-Events/Upcoming-congresses/Frontiers-in-Cardiovascular-Biology/Frontiers-in-Cardiovascular-Biology).

The papers are freely available online in the ‘Focus on cardiovascular protection’ virtual issue which can be accessed at bit.ly/CVR-FCVB

After the recent disappointment of the CIRCUS trial,1 new ideas for cardioprotection during reperfusion after ischaemia are needed with strong mechanistic support and preclinical evaluation. A meta-analysis of large animal studies further underscores the need for critical evaluation of study design and preclinical data interpretation for translation,2 a principle also advanced by the editors of Cardiovascular Research .3 Novel strategies for cardioprotection need to be tested in a clinically relevant framework, as laid out in the position paper of the ESC Working Groups Cellular Biology of the Heart.4 Novel ideas are generated in mechanistic studies as well as more translational studies.

Mitochondria are main actors involved in I/R injury. Inhibition of mitochondrial permeability transition pore (mPTP) opening is know to be cardioprotective; the role of UCP3 was uncovered through targeted molecular interventions5 while during I/R several activation mechanisms …
Multiple dilemmas of help and counteraction to teaching in complex social worlds
Authors: Alexander Poddiakov
Journal: Behavioral and Brain Sciences (2015)

Abstract Human civilization has a system of different social tools, institutions, and types of positive and negative work with teaching/learning determined by different interests of many actors. Negative work is more hidden and less studied. A paradoxical adaptive problem for teachers with good intentions is design of teaching/learning that equips pupils for learning in future environments unknown to the teachers.
Charity warns of humanitarian catastrophe in Nigeria
Authors: Anne Gulland
Journal: BMJ (2016)

A “catastrophic humanitarian emergency” is unfolding in a camp for internally displaced people in Nigeria, where more than 150 children have been found to have severe acute malnutrition.

The warning came from a medical team from the charity Medecins Sans Frontieres that visited the camp in the town of Bama in northeast Nigeria on 21 June. Nutritional screening of more than 800 children showed that almost …
Impact Of Autologous Stem Cell Transplantation In Older Patients With Mantle Cell Lymphoma
Authors: Zachary Frosch, Marlise R. Luskin, Daniel J. Landsburg, Stephen J. Schuster, Jakub Svoboda, Alison W. Loren, David L. Porter, Edward A. Stadtmauer, Sunita Dwivedy Nasta
Journal: Blood (2013)
Industry Payments to Physicians and Prescribing of Brand-name Drugs
Authors: Robert Steinbrook
Journal: JAMA Internal Medicine (2016)

Under the Open Payments program (the Physician Payment Sunshine Act, which is part of the Affordable Care Act), the Centers for Medicare & Medicaid Services has published nearly 16 million financial transactions from health care industries to physicians and teaching hospitals for August 2013 through December 2014.The total value of these payments was $9.92 billion.The Centers for Medicare & Medicaid Services will soon publish billions of dollars of additional transactions from 2015.Health care companies are investor-owned businesses that are obliged to maximize profits by any legal means.They are not charities; clearly they believe that billions of dollars of investments will have good returns.In this issue of JAMA Internal Medicine, DeJong and colleagues, 1 using 2013 data from the Open Payments program and prescribing data for individual physicians from Medicare Part D, report an association between receipt of industrysponsored meals, even just a single meal, and an increased rate of prescribing the brand-name medication that was being promoted.This study adds to the recent report in this journal from Yeh and colleagues, 2 using 2011 data, on the association of industry payments to physicians in Massachusetts with higher rates of prescribing brand-name statins.It also adds to the recent analysis by ProPublica, using 2014 Open Payments and Medicare Part D data, showing that "doctors who got money from drug and device makers-even just a meal-prescribed a higher percentage of brand-name drugs overall than doctors who didn't" and "the more money doctors receive…the more brand-name drugs they tend to prescribe." 3In 2014, pay-
Use of Mobile Devices, Social Media, and Crowdsourcing as Digital Strategies to Improve Emergency Cardiovascular Care
Authors: John S. Rumsfeld, Steven C. Brooks, Tom P. Aufderheide, Marion Leary, Steven M. Bradley, Chileshe Nkonde-Price, Lee H. Schwamm, Mariell Jessup, Jose Maria E. Ferrer, Raina M. Merchant
Journal: Circulation (2016)

myocardial infarction ◼ social media ◼ stroke
Olanzapine Linked With Potentially Fatal Skin Reaction
Authors: Rebecca Voelker
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Eculizumab Treatment Improves Outcomes of Pregnancy in Patients with Paroxysmal Nocturnal Hemoglobinuria
Authors: Richard J Kelly, Britta Höchsmann, Austin Kulasekararaj, Sophie de Guibert, Alexander Röth, Ilene C Weitz, Elina Armstrong, Anita Hill, Antonio M. Risitano, Christopher J Patriquin, Louis Terriou, Petra Muus, Michelle P Turner, Hubert Schrezenmeier, Jeffrey Szer, Regis Peffault de Latour
Journal: Blood (2014)
High-Throughput Sequencing to Identify Cytogenetic and Molecular Genetic Aberrations in 24 AML Exomes
Authors: Sonja Althammer, Andreia de Albuquerque, Niroshan Nadarajah, Manja Meggendorfer, Susanne Schnittger, Wolfgang Kern, Torsten Haferlach, Claudia Haferlach
Journal: Blood (2014)
Cancer During Pregnancy: a Case-Control Analysis of Mental Development and Cardiac Functioning of 38 Children Prenatally Exposed to Chemotherapy
Authors: F. Amant, T. Vandenbroucke, M. Verheecke, P.B. Ottevanger, M. Fumagalli, L. Mertens, S.N. Han, K. van Calsteren, L. Claes
Journal: Annals of Oncology (2014)
Moses Maimonides' treatise on poisons
Authors: F. Rosner
Journal: JAMA (1968)

The<i>Treatise on Poisons and Their Antidotes</i>was written by Moses Maimonides, in two parts, at the request of his lord protector, the Visier Kadhi Al Fadhil,<sup>1</sup>also known as Abu-Rahim ben 'Ali el Beisani,<sup>2</sup>in the Muhammadan month of Ramadhan in the year 595 (corresponding approximately to July 1198). Maimonides himself states this in the introduction to his work, where he also mentions that he entitled his discourse<i>Treatise to the Honored One or Treatise of Fadhil</i>: It was in the month of Ramadhan in the year 595 that His Highness addressed his humble servant and said: "It occurred to me yesterday that someone might be bitten by a poisonous animal and the poison spread throughout his body... and he would die... therefore, I order you... to write a short and concise manual of first aid to the bitten person." In compliance with the command and wish
GLUTATHIONINE S-TRANSFERASE THETA 1 (GSTT1) MISMATCH DOES NOT ACCOUNT FOR POST LIVER TRANSPLANT DE NOVO AUTOIMMUNE HEPATITIS
Authors: Tassos Grammatikopoulos, Maria G. Mytilinaiou, Dimitrios P. Bogdanos, Richard J. Thompson, Nedim Hadzic, Giorgina Mieli-Vergani, Diego Vergani
Journal: Hepatology (2009)
Efficacy of novel proteasome inhibitory platinum complex against osteosarcoma.
Authors: Kentaro Igarashi, Norio Yamamoto, Toshiharu Shirai, Katsuhiro Hayashi, Hideji Nishida, Yoshikazu Tanzawa, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Hiroyuki Inatani, Shingo Shimozaki, Takashi Kato, Akira Odani, Hiroyuki Tsuchiya
Journal: Journal of Clinical Oncology (2014)

10534 Background: We have developed novel proteasome inhibitory mononuclear platinum compound; 1Pt. We have already reported in vivo study of this compound against osteosarcoma cell lines. Now, we performed comparative studies of our novel proteasome inhibitory platinum compounds against cisplatin resistant osteosarcoma cell lines. And we performed in vitro study using orthotopic mouse model. Then, we also accessed expression of apoptosis related protein after drug exposure. Methods: The novel proteasome inhibitory platinum complex was synthesized by Prof. Odani. Cisplatin and proteasome inhibitory platinum were used in this study. Three cell lines (MG63, 143B, and LM8) and three cisplatin resistant cell lines (MG63cis-R, 143BcisR, LM8-cisR) were used. Cell survival after a 72 hrs exposure to these compounds was assessed by WST-8 assay, and IC50 value was calculated for each compound. Apoptosis was assessed by DNA fragmentation and Annexin V / PI assay. DNA double-strand breaks were assessed by acetylation of histon H2AX. Proteasome inhibitory activity was assessed by 20S proteasome assay kit. Expression of apoptotic related protein was accessed by western blotting. In vivo, 143B was transplanted to the tibia of nude mice, and treated with each drugs. Results: Both compound strongly caused concentration-dependent cytocidal effect. IC50 value of 1Pt was relatively high. 1Pt does not show cross resistance to cisplatin. Apoptosis induction and acetylation of histon H2AX were observed. Proteasome activity was surpressed after 1Pt administration. Expression of apoptotic related protein was up-regulated after 1Pt exposure. In orthotopic mouse model, 1Pt showed stronger anti-tumor effect, in dose escalation model, compared to cisplatin. Conclusions: 1Pt showed moderate anti-tumor activity against osteosarcoma cell line in vitro and showed suppression of proteasome activity. 1Pt had no cross resistance to cisplatin. In ortotopic mouse model, 1Pt showed stronger anti-tumor activity compared to cisplatin.
Technical and Instrumental Requirements for Arthroscopy of the Knee Joint
Authors: R. Jäger
Journal: Endoscopy (1980)

The use of the endoscope for the inspection of the interior of the knee joint makes high demands on OR hygiene, which is a general prerequisite for the examination. Knee joint arthroscopy can be carried out either under general or local anaesthesia; the advantages and disadvantages of the two procedure are compared. Various optical systems are in common use, the best quality images both for the examination itself and for photographic documentation, area obtained when the interior of the joint, distended by a gaseous medium, is inspected using a lens-type optical system.
Development of a phase 2 study of the aurora kinase-A inhibitor alisertib (MLN8237) in pretreated patients (pts) with urothelial cancer (UC).
Authors: Andrea Necchi, Luigi Mariani, Patrizia Giannatempo, Daniele Raggi, Elena Farè, Alfonso Marchianò, Flavio Crippa, Elena Togliardi, Maria Grazia Daidone, Alessandro M. Gianni, Roberto Salvioni, Filippo G. De Braud
Journal: Journal of Clinical Oncology (2014)

TPS4592 Background: Progress in developing new effective therapies in advanced and relapsing urothelial cancer has been stagnant in the last few decades and a paradigm shift is desperately needed. Aurora kinase-A overexpression has been previously described in bladder cancer and spindle checkpoint dysregulation is a common feature of human UC. Alisertib (Millennium Inc.) is an orally available, selective small molecule inhibitor of Aurora A kinase. Single agent and combination treatment of MLN8237 with either paclitaxel (TXL) or gemcitabine synergistically reduced UC cell viability compared with either drug alone. Hence, sequential application of MLN8237 and TXL warrants clinical investigation. Phase 1 trials of both single agent and the combination with TXL defined the recommended doses for phase 2 trials. Methods: A multistep approach will be adopted for this Phase 2 trial. A single-group run-in phase will be conducted first with Alisertib 50 mg orally BID for 7 days, followed by 14d rest until disease progression. In case of activity, a confirmatory randomized (1:1) trial of weekly TXL plus either Alisertib or Placebo will follow, incorporating efficacy and futility boundaries for early stopping. In a single-blind design, TXL will be given on days 1,8,15 q4wks at the dose of 60 mg/m2 with alisertib and 80 mg/m2 with placebo. Alisertib dose will be 40 mg BID days 1-3, 8-10 and 15-17, q4wks. In the single-arm phase, primary endpoint (EP) will be RECIST 1.1 response-rate. 20 pts will be accrued, ≥3 responses will be required (10% type I and 20% type II error costraints). An accrual of 110 pts is foreseen in the randomized phase. Primary EP: progression-free survival (PFS), assuming an improvement in PFS from a median of 2.5 months (H0) to a median of 4.5 months (H1) (44% hazard rate reduction, 10% drop out rate). Eligibility will include diagnosis of metastatic UC and failure of 1-2 CT regimens (single-arm) or 1 prior CT only (randomized phase). A relapse within 6 months of a peri-operative CT will be counted as 1 line. Computed tomography and PET will be done every 2 cycles (2 months). Additional pharmacodynamic and translational analyses are planned on pre- post- blood and tissue samples. Clinical trial information: 2014-000557-36.
Abstract 2890: Nesiritide Enhances Myocardial Protection during the Revascularization of Acutely Ischemic Myocardium
Authors: Harold L Lazar, Yusheng Bao, Deborah Siwik, Jeffrey Frame, Carlos San Mateo, Wilson Colucci
Journal: Circulation (2008)

Nesiritide, a recombinant human B-type natriuretic peptide, has been used in conjunction with inotropic agents in the postoperative management of low cardiac output and pulmonary hypertension. However, its effects on intraoperative myocardial protection are unknown. This study was therefore undertaken to determine whether Nesiritide could enhance myocardial protection when given intraoperatively in a porcine model simulating urgent CABG surgery. Twenty pigs underwent occlusion of the second and third diagonal coronary arteries using snares for 90 minutes followed by 45 minutes of antegrade, cold blood cardioplegic arrest and 180 minutes of reperfusion on cardiopulmonary bypass(CPB) during which time the snares were released. Ten animals received an IV bolus of Nesiritide(2ug/kg) at the initiation of coronary occlusion followed by a 0.01ug/kg/min IV infusion during coronary occlusion, cardioplegic arrest, and reperfusion on CPB. Ten other animals underwent the same protocal without Nesiritide(placebo). Infarct size was assessed by the area of necrosis/area of risk(AN/AR) using histochemical staining, endothelial function by the % change in coronary vasodilation using ring chamber methodology, and lung edema using % change in wet/dry weights. The data is expressed as the mean+/− standard deviation. Nesiritide treated hearts had significantly decreased infarct size, better preservation of endothelial function, and less lung edema. In a porcine model of acute coronary occlusion simulating urgent CABG surgery, the intraoperative infusion of Nesiritide limited myocardial damage. These data suggest that IV Nesiritide infusions may afford increased myocardial protection when administered intraoperatively during the revascularization of acutely ischemic myocardium. RESULTS
Case 50-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Kurt J. Isselbacher, Benjamin Castleman
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 63-year-old man was admitted to the hospital because of increasing congestive heart failure.He had diabetes of 15 years' duration, managed with diet and tolbutamide. Seven years before admission there was a transient episode of dysphasia, accompanied by right brachiofacial monoparesis. Three years before entry a prosthetic aortic valve was inserted because of aortic stenosis with atrial fibrillation and congestive heart failure; the procedure was complicated by a bleeding duodenal ulcer. Thereafter, he was maintained on warfarin therapy. Several months before admission indomethacin was given because of acute gouty arthritis. Three months before entry a dentist . . .
Case 37-1965
Authors: Gerald R. Plotkin, Wallace A. Jones
Journal: New England Journal of Medicine (1965)

Presentation of CaseA forty-two-year-old television repairman was admitted to the hospital because of jaundice.He had been well until seventeen days previously, when he became febrile and acquired a distaste for his usual cigars. A physician prescribed sulfamethoxazole (Gantanol), which was given for five days. The fever subsided after one week, and he returned to work. Four days before entry the fever recurred, and two days later icterus and the passage of dark urine were observed. He lost 5 pounds in weight during the two weeks before admission.Two years earlier he fled Cuba and resided for six months . . .
Comparison of Immature Platelet Count to Established Predictors of Platelet Reactivity During Thienopyridine Therapy
Authors: Christian Stratz, Timo Bömicke, Iris Younas, Anja Kittel, Michael Amann, Christian M. Valina, Thomas Nührenberg, Dietmar Trenk, Franz-Josef Neumann, Willibald Hochholzer
Journal: Journal of the American College of Cardiology (2016)
Treatment of Allergic Patients with Betamethasone: An Evaluation
Authors: D B FRANKEL, A L AARONSON, N J EHRLICH
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
808 nm-excited upconversion nanoprobes with low heating effect for targeted magnetic resonance imaging and high-efficacy photodynamic therapy in HER2-overexpressed breast cancer
Authors: Leyong Zeng, Yuanwei Pan, Ruifen Zou, Jinchao Zhang, Ying Tian, Zhaogang Teng, Shouju Wang, Wenzhi Ren, Xueshan Xiao, Jichao Zhang, Lili Zhang, Aiguo Li, Guangming Lu, Aiguo Wu
Journal: Biomaterials (2016)
Foyer épidémique de légionelloses à Paris en juin 1998
Authors: B Decludt, L Guillotin, B van Gastel, A Perrocheau, L Capek, M Ledrans, J Etienne, D Carlier, S Jarraud, S Dubrou, M Reyrolle
Journal: Eurosurveillance (1999)

Du 29 juin au 1er juillet 1998, quatre cas de legionellose survenus chez des ressortissants britanniques ont ete signales au Reseau National de Sante Publique (RNSP) par le systeme de la declaration obligatoire (DO) et par le Reseau europeen de surveillance des legionelloses liees aux voyages coordone par le European Working Group for Legionella Infections (EWGLI). Un des cas avait ete detecte par la surveillance renforcee mise en place a l'occasion de la coupe du monde de football. Ces personnes avaient toutes sejourne a Paris dans les 10 jours precedant le debut des symptomes. Une enquete a ete conduite afin de confirmer l'existence d'un episode epidemique, d'identifier une source commune de contamination et de mettre en œuvre des mesures de controle adaptees a la situation epidemiologique.
The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum
Authors: Evelien M. Bunnik, Gayani Batugedara, Anita Saraf, Jacques Prudhomme, Laurence Florens, Karine G. Le Roch
Journal: Genome biology (2016)

Gene expression is controlled at multiple levels, including transcription, stability, translation, and degradation. Over the years, it has become apparent that Plasmodium falciparum exerts limited transcriptional control of gene expression, while at least part of Plasmodium’s genome is controlled by post-transcriptional mechanisms. To generate insights into the mechanisms that regulate gene expression at the post-transcriptional level, we undertook complementary computational, comparative genomics, and experimental approaches to identify and characterize mRNA-binding proteins (mRBPs) in P. falciparum. Close to 1000 RNA-binding proteins are identified by hidden Markov model searches, of which mRBPs encompass a relatively large proportion of the parasite proteome as compared to other eukaryotes. Several abundant mRNA-binding domains are enriched in apicomplexan parasites, while strong depletion of mRNA-binding domains involved in RNA degradation is observed. Next, we experimentally capture 199 proteins that interact with mRNA during the blood stages, 64 of which with high confidence. These captured mRBPs show a significant overlap with the in silico identified candidate RBPs (p < 0.0001). Among the experimentally validated mRBPs are many known translational regulators active in other stages of the parasite’s life cycle, such as DOZI, CITH, PfCELF2, Musashi, and PfAlba1–4. Finally, we also detect several proteins with an RNA-binding domain abundant in Apicomplexans (RAP domain) that is almost exclusively found in apicomplexan parasites. Collectively, our results provide the most complete comparative genomics and experimental analysis of mRBPs in P. falciparum. A better understanding of these regulatory proteins will not only give insight into the intricate parasite life cycle but may also provide targets for novel therapeutic strategies.