PATHOGENETIC MECHANISMS IN IDIOPATHIC THROMBOCYTOPENIC PURPURA
Authors: P. W. C.
Journal: Annals of Internal Medicine (1953)

Editorial1 August 1953PATHOGENETIC MECHANISMS IN IDIOPATHIC THROMBOCYTOPENIC PURPURAP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-2-379 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThis syndrome has long been a puzzling problem both as to its underlying cause and its pathogenesis. Recent studies which reveal the mechanisms apparently concerned in some of these cases constitute important contributions to this subject. These "idiopathic" cases must be distinguished from primary diseases of the bone marrow, such as acute leukemia or aplastic anemia, in which the lack of platelets is a subsidiary phenomenon. It is also customary to distinguish them from those cases for which there is a demonstrable cause, such as a hypersensitive reaction to certain drugs, although in other respects clinically they may be virtually...1 DameshekMiller WEB: The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism, Blood 1: 27-52, 1946. CrossrefMedlineGoogle Scholar2 Doan CA: Hypersplenism, Bull. New York Acad. Med. 25: 625-650, 1949. MedlineGoogle Scholar3 HarringtonMinnichHollowingsworthMoore WJVJWCV: Demonstration of a thrombocytopenic factor in the blood of patients with idiopathic thrombocytopenic purpura, J. Lab. and Clin. Med. 36: 1-10, 1951. Google Scholar4 StefaniniDameshekChatterjeaAdelsonMednicoff MWJBEIB: Studies of platelets. IX. Observations on the properties and mechanism of action of a potent platelet agglutinin detected in the serum of a patient with idiopathic thrombocytopenic purpura (with a note on the pathogenesis of the disease), Blood 8: 26-64, 1953. CrossrefMedlineGoogle Scholar5 EpsteinLoznerCobbeyDavidson RDELTSCS: Congenital thrombocytopenic purpura, purpura hemorrhagica in pregnancy and in the new born, Am. J. Med. 9: 41-56, 1950. CrossrefGoogle Scholar6 Ackroyd JF: The mechanism of the reduction of clot retraction by Sedormid in the blood of patients who have recovered from Sedormid purpura, Clin. Sc. 8: 235-267, 1949. MedlineGoogle Scholar7 HirschDameshek EOW: Thrombocytopenic purpura due to allergy to quinidine. Study of the mechanism of thrombocytopenia, Am. J. Med. 9: 828-833, 1950. CrossrefMedlineGoogle Scholar8 Larson RK: The mechanism of quinidine purpura, Blood 8: 16-25, 1953. CrossrefMedlineGoogle Scholar9 Evans RS: Primary thrombocytopenic purpura and acquired hemolytic anemia; evidence for a common etiology, Arch. Int. Med. 87: 48-65, 1951. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPROGRESS OF IRON AND STEEL CASTING INDUSTRY IN JAPAN 1 August 1953Volume 39, Issue 2Page: 379-382KeywordsAplastic anemiaBone marrowDrugsIdiopathic thrombocytopenic purpuraPathogenesisPlatelets ePublished: 1 December 2008 Issue Published: 1 August 1953 PDF downloadLoading ...