tbuckley/cabot-search huggingface dataset:
Combination Chemoimmunotherapy Using Alemtuzumab, Fludarabine, Cyclophosphamide, and Doxorubicin (Campath-FCD) Is an Effective First-Line Regimen in Peripheral T-Cell Lymphomas.
Authors: Eckhart Weidmann, Georg Hess, Stefan W. Krause, Holger Hebart, Martin Dreyling, Marion Subklewe, Christine Falge, Kai U. Chow, Elke Jaeger, Parisis S. Mitrou
Journal: Blood (2004)
Hepatitis A among persons with hemophilia who received clotting factor concentrate - United States, September-December 1995 (Reprinted from MMWR, vol 45, pg 29-32, 1996)
Authors: FB Ruymann, CE Krill, TJ Halpin, WH Churchill, B Ewenstein, A DeMaria, MJ MancoJohnson, RE Hoffman
Journal: JAMA (1996)
Improved Relapse Free Survival Is Predicted by a Negative Pre-Transplant FDG-PET Scan Following Salvage Chemotherapy for Relapsed Diffuse Large B Cell Lymphoma (DLBCL) Treated with Autologous Stem Cell Transplantation.
Authors: Michael J. Dickinson, Rosemary Hoyt, Andrew Roberts, Andrew Grigg, John Francis Seymour, Jeff Szer, H. Miles Prince, David Ritchie
Journal: Blood (2007)
RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers
Authors: Sheeba Irshad, Fabian Flores-Borja, Katherine Lawler, James Monypenny, Rachel Evans, Victoria Male, Peter Gordon, Anthony Cheung, Patrycja Gazinska, Farzana Noor, Felix Wong, Anita Grigoriadis, Gilbert O. Fruhwirth, Paul R. Barber, Natalie Woodman, Dominic Patel, Manuel Rodriguez-Justo, Julie Owen, Stewart G. Martin, Sarah E. Pinder, Cheryl E. Gillett, Simon P. Poland, Simon Ameer-Beg, Frank McCaughan, Leo M. Carlin, Uzma Hasan, David R. Withers, Peter Lane, Borivoj Vojnovic, Sergio A. Quezada, Paul Ellis, Andrew N.J. Tutt, Tony Ng
Journal: Cancer Research (2017)

Abstract Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the presence of increased numbers of RORγt+ group 3 innate lymphoid cells (ILC3) correlates with an increased likelihood of lymph node metastasis. In a preclinical mouse model of breast cancer, CCL21-mediated recruitment of ILC3 to tumors stimulated the production of the CXCL13 by TME stromal cells, which in turn promoted ILC3–stromal interactions and production of the cancer cell motile factor RANKL. Depleting ILC3 or neutralizing CCL21, CXCL13, or RANKL was sufficient to decrease lymph node metastasis. Our findings establish a role for RORγt+ILC3 in promoting lymphatic metastasis by modulating the local chemokine milieu of cancer cells in the TME. Cancer Res; 77(5); 1083–96. ©2017 AACR.
Definition of a Prognostic Scoring System for Predicting Clinical Outcome in B-Cell Chronic Lymphocytic Leukemia.
Authors: Fortunato Morabito, Giovanna Cutrona, Massimo Gentile, Serena Matis, Monica Colombo, Eugenio Lucia, Mauro Spriano, Edoardo Rossi, Vincenzo Callea, Caterina Stelitano, Carla Mazzone, Ernesto Vigna, Carlo Gentile, Gianluca Festini, Antonino Neri, Simonetta Zupo, Stefano Molica, Nicholas Chiorazzi, Manlio Ferrarini
Journal: Blood (2006)
Feasibility of Reduced-Intensity Cord Blood Transplantation (RICBT) as a Salvage Therapy for Graft Failure (GF): Results of a Nationwide Survey of 63 Patients.
Authors: Fusako Ohara, Kazuhiro Masuoka, Takahiro Fukuda, Yoshinobu Kanda, Mika Nakamae, Katsuhiro Togami, Kimikazu Yakushijin, Kaichi Nishiwaki, Yasunori Ueda, Fumio Kawano, Takuya Yamashita, Masaharu Kasai, Koji Nagafuji, Maki Takabayashi, Kazuo Hatanaka, Masafumi Taniwaki, Yoshinobu Maeda, Naoki Shirafuji, Atae Utsunomiya, Toshiki Uchida, Takehiko Mori, Tetsuya Eto, Kazuaki Yakushiji, Hitoshi Nakagawa, Makoto Murata, Kosei Matsue, Yoichi Takaue, Shuichi Taniguchi
Journal: Blood (2006)
The Plasma Concentrations of the Anorexigenic PYY and Orexigenic Ghrelin Decrease and Increase Respectively during Chemotherapy in Children with Acute Lymphoblastic Leukaemia, as the Leukemic Burden Is Gradually Eliminated and the Body Weight Improves.
Authors: Maria Moschovi, Maria Vounatsou, Ioannis Papassotiriou, George P. Chrousos, Fotini Tzortzatou-Stathopoulou
Journal: Blood (2005)
Cost Description on a Cohort of 659 Patients with Adult MDS Included into the Italian Lazio Region Registry (the GROM-L)
Authors: Carlo Lazzaro, Maria Antonietta Aloe-Spiriti, Maria Teresa Voso, Roberto Latagliata, Francesco Buccisano, Susanna Fenu, Luca Maurillo, Roberto Ricci, Luana Fianchi, Gina Zini
Journal: Blood (2015)
Human B Cell Development from Adult Bone Marrow Is Profoundly Dependent on IL-7 Due to Decreased B Lymphoid Generative Capacity.
Authors: Yasmin K. Parrish, Ineavely Baez, Terry-Ann M. Milford, Jaqueline W. Rogerio, Eva Sahakian, Mercy Kagoda, Abigail Benitez, Grace Huang, Kimberly J. Payne
Journal: Blood (2007)
The Kinase Inhibitor TKI258 Is Active Against the Novel CUX1-FGFR1 Fusion Detected In a Patient with T-Lymphoblastic Leukemia/Lymphoma and t(7;8)(q22;p11)
Authors: Bartosz Wasag, Els Lierman, Peter Meeus, Jan Cools, Peter Vandenberghe
Journal: Blood (2010)
Prediction of Primary Treatment Outcome Using Gene Expression Profiling of Pre-Treatment Biopsies Obtained from Childhood and Adolescent Hodgkin Lymphoma Patients
Authors: Anja Mottok, Rebecca Lea Johnston, Fong Chun Chan, David W Scott, Debra L. Friedman, Cindy Schwartz, Kara M. Kelly, Terzah M. Horton, Christian Steidl
Journal: Blood (2015)
Angiopoietin-like protein 2 is a positive regulator of osteoblast differentiation
Authors: Aiko Takano, Takao Fukuda, Takanori Shinjo, Misaki Iwashita, Etsuko Matsuzaki, Kensuke Yamamichi, Masaaki Takeshita, Terukazu Sanui, Fusanori Nishimura
Journal: Metabolism (2017)
Inhibition of Intracellular Triglyceride Lipolysis Suppresses Cold-Induced Brown Adipose Tissue Metabolism and Increases Shivering in Humans
Authors: Denis P. Blondin, Frédérique Frisch, Serge Phoenix, Brigitte Guérin, Éric E. Turcotte, François Haman, Denis Richard, André C. Carpentier
Journal: Cell Metabolism (2017)
Prognostic Factors and Response Duration in 419 MDS Treated with Erythropoietin±GCSF: The GFM Experience.
Authors: S. Park, C. Kelaidi, S. Grabar, O. Beyne-Rauzy, S. Cheze, V. Bardet, M. Escoffre-Barbe, C. Ravoet, A. Ferrant, N. Vey, H. Dombret, B. Mahe, L. Mannone, L. Legros, L. Aljassem, A. Stamatoullas, D. Vassilief, M.C. Quarre, L. Ades, V. Andrieux, S. Giraudier, S. de Botton, N. Casadevall, P. Fenaux, F. Dreyfus
Journal: Blood (2006)
Efficacy and safety of once-weekly semaglutide monotherapy versus placebo in patients with type 2 diabetes (SUSTAIN 1): a double-blind, randomised, placebo-controlled, parallel-group, multinational, multicentre phase 3a trial
Authors: Christopher Sorli, Shin-ichi Harashima, George M Tsoukas, Jeffrey Unger, Julie Derving Karsbøl, Thomas Hansen, Stephen C Bain
Journal: The Lancet Diabetes & Endocrinology (2017)
Multilayer Nanoscale Encapsulation of Biofunctional Peptides to Enhance Bone Tissue Regeneration In Vivo
Authors: Piergiorgio Gentile, Ana Marina Ferreira, Jill T. Callaghan, Cheryl A. Miller, Joss Atkinson, Christine Freeman, Paul V. Hatton
Journal: Advanced Healthcare Materials (2017)

Bone tissue healing is a dynamic process that is initiated by the recruitment of osteoprogenitor cells followed by their migration, proliferation, differentiation, and development of a mineralizing extracellular matrix. The work aims to manufacture a functionalized porous membrane that stimulates early events in bone healing for initiating a regenerative cascade. Layer‐by‐layer (LbL) assembly is proposed to modify the surface of osteoconductive electrospun meshes, based on poly(lactic‐co‐glycolic acid) and nanohydroxyapatite, by using poly(allylamine hydrochloride) and poly(sodium 4‐styrenesulfonate) as polyelectrolytes. Molecular cues are incorporated by grafting peptide fragments into the discrete nanolayers. KRSR (lysine‐arginine‐serine‐arginine) sequence is grafted to enhance cell adhesion and proliferation, NSPVNSKIPKACCVPTELSAI to guide bone marrow mesenchymal stem cells differentiation in osteoblasts, and FHRRIKA (phenylalanine‐histidine‐arginine‐arginine‐isoleucine‐lysine‐alanine) to improve mineralization matrix formation. Scanning electron microscopy, infrared spectroscopy, and X‐ray photoelectron spectroscopy demonstrate the successful surface functionalization. Furthermore, the peptide incorporation enhances cellular processes, with good viability and significant increase of alkaline phosphatase activity, osteopontin, and osteocalcin. The functionalized membrane induces a favorable in vivo response after implantation for four weeks in nonhealing rat calvarial defect model. It is concluded that the multilayer nanoencapsulation of biofunctional peptides using LbL approach has significant potential as innovative manufacturing technique to improve bone regeneration in orthopedic and craniofacial medical devices.
A UK Cost-Effectiveness Analysis Comparing First Line Treatment with Rituximab in Combination with Fludarabine and Cyclophosphamide Versus Fludarabine and Cyclophosphamide Alone in Chronic Lymphocytic Leukemia (CLL) Patients
Authors: Konstantinos Papadakis, David Oscier, Emma SC Carr, Gavin Lewis, Rick Aultman
Journal: Blood (2008)
Functional and geometrical interference and interdependency between the right and left ventricle in cor pulmonale: An experimental study on simultaneous measurement of biventricular geometry of acute right ventricular pressure overload.
Authors: Hirohisa Yamashita, Sokichi Onodera, Tetsuro Imamoto, Atsushi Obara, Satoshi Tanazawa, Tetsuya Takashio, Hideo Morimoto, Hitoki Inoue
Journal: Circulation (1989)

To clarify the effects of right ventricular (RV) pressure overload on functional and geometrical interference and interdependency between the right and left ventricle, both ventricular internal diameters were measured by the microcrystal technique during lycopodium induced pulmonary embolization in the dog. By repeated embolization, RV systolic pressure was increased progressively until it reached a peak value of about 60-70 mmHg, then it began to fall. At the same time, the hemodynamics deteriorated progressively resulting in death. During the experiment, gradual leftward displacement of the interventricular septum (IVS) without any change in left ventricular (LV) free wall geometry was observed. In pulmonary embolic shock, which shoed a fall in LV pressure to about 60 mmHg and cardiac output to about 40% of control, the leftward displacement of IVS became marked, and the cooperative movement of IVS to LV contraction disappeared. The IVS position during acute RV pressure overload was able to account for the trans-septal pressure gradient. The importance of IVS position and motion in cardiac function during acute RV pressure overload was stressed. Furthermore, to establish the theoretical treatment in acute cardiopulmonary resuscitation, ligation of the descending aorta (AoL) or norepinephrine (N) or isoproterenol (I) administration were examined in a canine pulmonary embolic shock model. AoL or N improved the deteriorated hemodynamics with restoration of biventricular geometry. However, I did not restore the biventricular geometry despite the transiently improved hemodynamics, and the experimental animals were unable to survive. These results suggest the importance of the maintainance of systemic pressure for the restoration of failed RV function. Further integrated studies are required to understand biventricular interference and interdependency.
A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped &amp; Ce6-doped mesoporous silica nanorods
Authors: Qi Sun, Qing You, Xiaojuan Pang, Xiaoxiao Tan, Jinping Wang, Li Liu, Fang Guo, Fengping Tan, Nan Li
Journal: Biomaterials (2017)
Improved Outcome of CLL Patients with Leukemic Clones Expressing Mutated IGHV May Not Be Due to An Inability to Bind (auto)Antigen In Vivo
Authors: Matthew Kaufman, Xiao-Jie Yan, Emanuela M. Ghia, Donna Neuberg, Laura Z Rassenti, Jennifer R Brown, John C. Byrd, Neil E. Kay, Kanti R Rai, Thomas J. Kipps, Nicholas Chiorazzi
Journal: Blood (2010)
Red Marrow Dosimetry and Stem Cell Reinfusion in High Dose 90Y - Ibritumomab Tiuxetan.
Authors: Anna Vanazzi, Daniele Laszlo, Marta Cremonesi, Chiara Maria Grana, Stefano Papi, Alessandra Alietti, Sarah Jayne Liptrott, Liliana Calabrese, Giovanni Paganelli, Giovanni Martinelli
Journal: Blood (2008)
Transplantation of Peripheral Blood Stem Cells Mobilized by Chemotherapy and Single Dose Pegylated G-CSF in Patients with Multiple Myeloma: Equivalence of 6 mg and 12 mg Pegfilgrastim.
Authors: Ingmar Bruns, Ulrich Steidl, Christof Scheid, Kai Hübel, Roland Fenk, Frank Neumann, Rainer Haas, Guido Kobbe
Journal: Blood (2004)
DNA Methylation Profiling of Childhood Acute Lymphoblastic Leukaemia Using Illumina Infinium DNA Methylation27 Bead Arrays Identifies a Distinct DNA Methylation Signature Associated with Leukaemogenesis
Authors: Nicholas C. Wong, Zac Chatterton, Katrina Bell, Adam Kowalcyk, Justin Bedo, Qiao Wang, Izhak Haviv, Elizabeth Algar, David Ashley, Jeff Craig, Richard Saffery
Journal: Blood (2010)
RAP-536, A Soluble Activin Receptor Type IIb Murine IgG-Fc Fusion Protein, Prevents Myelodysplastic Syndrome Related Anemia
Authors: Aaron Mulivor, Samuel M. Cadena, Rajasekhar NVS Suragani, Ravindra Kumar, Kathryn Underwood, Jas Seehra, R. Scott Pearsall
Journal: Blood (2010)
Physical Activity on the Weekend
Authors: Hannah Arem, Loretta DiPietro
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Transfusion Need at Diagnosis or Its Development During the First Year of Diagnosis in Primary Myelofibrosis: Effect On Survival and Correlation with JAK2 and TET2 Mutational Status.
Authors: Ayalew Tefferi, Sergio Siragusa, Rakhee Vaidya, Susan Schwager, Kebede Hussein, Curtis A. Hanson, Animesh D. Pardanani, Francisco Cervantes, Francesco Passamonti
Journal: Blood (2009)
Inhibition of Mitogen Activated Protein Kinase Kinase (MEK1) Is Effective Against CLL Cells Cultured in Media Alone or in a Supportive Microenvironment and Is Synergistic with Fludarabine in a Mechanism That Involves Decreased Levels of Reactive Oxygen Species and MCL-1 Protein
Authors: Giles Best, Kyle Crassini, Williams Stevenson, Stephen P. Mulligan
Journal: Blood (2012)
Initial Presentation and Prognostic Factors in 286 Patients with T-Cell Large Granular Lymphocyte Leukemia.
Authors: Grzegorz S. Nowakowski, William G. Morice, Clive S. Zent, Susan M. Schwager, Chin-Yang Li, Svetomir N. Markovic, Luis Porrata, Ayalew Tefferi, Robert L. Phyliky
Journal: Blood (2006)
Induction of CABLES1 by the TKI Inhibits the Cell Cycle Progression and Induces Apoptosis In CML Cell.
Authors: Tomonari Takemura, Satoki Nakamura, Yasuyuki Nagata, Daisuke Yokota, Isao Hirano, Takaaki Ono, Kazuyuki Shigeno, Shinya Fujisawa, Kazunori Ohnishi
Journal: Blood (2010)
An interim analysis of a phase II study of the combination of TACE and sorafenib in patients with unresectable hepatocellular carcinoma in National Cancer Center Korea (COTSUN KOREA, NCT00919009).
Authors: J. Park, H. Kim, J. Shim, S. Woo, J. Choi, B. Nam
Journal: Journal of Clinical Oncology (2011)

253 Background: Transarterial chemoembolization (TACE) is the palliative treatment for patients with unresectable HCC. TACE-induced ischemic injury is known to increase circulating VEGF and related with poor prognosis.The aim of this study is to evaluate efficacy and safety of combined TACE with sorafenib, VEGFR inhibitor in unresectable HCC patients. Methods: This study is a non-randomized, open-labeld, single-arm, phase II investigator-initiated clinical study. Estimated number of subjects was 50 under the assumption of 3.2 months of median time to progression (TTP) with TACE alone. All patients are Child-Pugh class A or superb B. Sorafenib begins to be administered on 3 days after the first session of TACE and will be subsequently administered up to 24 weeks. Efficacy of TACE was evaluated after 4 weeks from TACE by dynamic CT. Repeated TACE is performed “on demand” in case of PR or SD according to CT/MRI evaluation. Results: A total of 50 patients were enrolled for this interim analysis. Male was 84% and mean age was 61.5years. Causes of underlying chronic liver disease were HBV in 28 patients (65.1%). Patients were categorized into modified UICC stage II (15, 30.0%), III (24, 48.0%) and IVA (11, 22.0%). Median follow-up period was 5.3 months (range, 1.0–13.1). The size of index lesions was ranged from 1.0 cm to 13.1 cm, and number of lesions was between 1 and 5. Number of TACE sessions was 1.0 (range, 1–4). Common adverse events (AE) during sorafenib therapy were elevation of serum AST/ALT (96.8%), hypocalcemia (90.0%), thrombocytopenia (84.0%), and hyperbilirubinemia (76.0%). Hand-foot skin reaction was most frequently observed among AE of NCI CTCAE grade 3 or higher (40.0%), followed by elevation of serum ALT (38.0%). Dose reduction of sorafenib was needed most commonly due to hand-food skin reaction (n=29). Median TTP was 5.1 months (range, 3.8–6.3). Conclusions: Adverse events were approved as acceptable by independent monitoring system. Preliminary evidence of antitumor activity was also observed. This trial can be safely performed with close monitoring in inoperable and/or unresectable HCC patients. No significant financial relationships to disclose.
The Functional Link Between CDK1 and Retinoic Acid Receptor γ (RARγ) in Response to Treatment with All-Trans Retinoic Acid
Authors: Andreas Hedblom, Kristian B Laursen, Regina R Miftakhova, Martuza Sarwar, Nigel P Mongan, Lorraine J Gudas, Jenny L Persson
Journal: Blood (2011)
Incidence, Risk Factors and Outcomes of Sclerotic Chronic Graft-Versus-Host Disease (GVHD) Phenotype After Allogeneic Hematopoietic Cell Transplantation
Authors: Yoshihiro Inamoto, Barry Storer, Effie W. Petersdorf, Paul A. Carpenter, Stephanie J. Lee, Lee Nelson, Brenda M. Sandmaier, Paul J. Martin, Mary E.D. Flowers
Journal: Blood (2011)
Very High Efficacy of Stem Cell Mobilization Using Intermadiate-Dose Cytosine Arabinoside + G-CSF in Patients with Lymphoid Malignancies, Including Predicted and Proven Poor Mobilizers
Authors: Tomasz Kruzel, Tomasz Czerw, Maria Sadus-Wojciechowska, Jacek Najda, Magdalena Glowala-Kosinska, Agata Chwieduk, Iwona Mitrus, Andrzej Smagur, Jerzy Holowiecki, Sebastian Giebel
Journal: Blood (2012)
Karyotypic and Genetic Abnormalities Associated with Clonal Evolution in Paroxysmal Nocturnal Hemoglobinuria.
Authors: Hideki Makishima, Kenichi Yoshida, Michael J. Clemente, Masashi Sanada, Yasunobu Nagata, Manuel G. Afable, Andres Jerez, Kenichi Chiba, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa, Jaroslaw P. Maciejewski
Journal: Blood (2012)
Pharmacodynamic Analysis of the Anticoagulant Effects of Idraparinuxparinux after Termination of 6 and 12 Months Therapy for Prevention of Recurrent Venous Thromboembolism: Observations after the vanGogh Trials.
Authors: Job Harenberg, Ingrid Joerg, Antje Hagedorn, Christina Giese, Christel Weiss, Gerd Mikus
Journal: Blood (2007)
Intra-Patient Variability in Recombinant Activated FVII (rFVIIa) Dosing Over 3 to 8 Year Periods in Patients with Congential Hemophilia with Inhibitors Experiencing Frequent Acute Bleeding Episodes: Analysis From the Hemostasis and Thrombosis Research Society (HTRS) Registry,
Authors: Ellis J. Neufeld, David L. Cooper
Journal: Blood (2011)
Cardiac Autonomic Dysfunction and Incidence of Atrial Fibrillation
Authors: Sunil K. Agarwal, Faye L. Norby, Eric A. Whitsel, Elsayed Z. Soliman, Lin Y. Chen, Laura R. Loehr, Valentin Fuster, Gerardo Heiss, Josef Coresh, Alvaro Alonso
Journal: Journal of the American College of Cardiology (2017)
Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2015
Authors: Mary B. Daly, Robert Pilarski, Jennifer E. Axilbund, Michael Berry, Saundra S. Buys, Beth Crawford, Meagan Farmer, Susan Friedman, Judy E. Garber, Seema Khan, Catherine Klein, Wendy Kohlmann, Allison Kurian, Jennifer K. Litton, Lisa Madlensky, P. Kelly Marcom, Sofia D. Merajver, Kenneth Offit, Tuya Pal, Huma Rana, Gwen Reiser, Mark E. Robson, Kristen Mahoney Shannon, Elizabeth Swisher, Nicoleta C. Voian, Jeffrey N. Weitzel, Alison Whelan, Myra J. Wick, Georgia L. Wiesner, Mary Dwyer, Rashmi Kumar, Susan Darlow
Journal: Journal of the National Comprehensive Cancer Network (2016)

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast and Ovarian provide recommendations for genetic testing and counseling and risk assessment and management for hereditary cancer syndromes. Guidelines focus on syndromes associated with an increased risk of breast and/or ovarian cancer and are intended to assist with clinical and shared decision-making. These NCCN Guidelines Insights summarize major discussion points of the 2015 NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meeting. Major discussion topics this year included multigene testing, risk management recommendations for less common genetic mutations, and salpingectomy for ovarian cancer risk reduction. The panel also discussed revisions to genetic testing criteria that take into account ovarian cancer histology and personal history of pancreatic cancer.
Dynamic Contrast-Enhanced Magnetic Resonance Imaging Identifies a Subgroup of Patients with Asymptomatic Monoclonal Plasma Cell Disease and Pathological Microcirculation
Authors: Jens Hillengass, Christian M Zechmann, Tobias Bäuerle, Christiane Heiss, Axel Benner, Kai Neben, Anthony D. Ho, Hartmut Goldschmidt, Stefan Delorme, Thomas M. Moehler
Journal: Blood (2008)
Impact of Inherited Thrombophilia Factors On Thrombotic Risk in Patients with Newly Diagnosed BCR- Abl (-) Myeloproliferative Disorders; Finally a Role of MTHFR- C677T Polymorphism?
Authors: Emmanouil Papadakis, Valia Papageorgiou, Konstantinos Tsepanis, Dionysia Theocharidou, Vassilios K Papadopoulos, Elissavet Georgiou, Smaragda Efraimidou, Anna Kioumi
Journal: Blood (2012)
Reduced Toxicity Conditioning (RTC) Compared to Myeloablative Conditioning (MAC) Prior to Unrelated Cord Blood Transplantation (UCBT) in Pediatric Recipients Was Associated with Similar but Also Delayed Time to Immune Reconstitution and a Concomitant Significant Decrease in Grade II-IV Agvhd.
Authors: Jason Freedman, Diane George, Judith Jacobson, Mark Geyer, Carmella van de Ven, Nathifa Fearon, Claire Fanelli, Bradford Tallamy, Prakash Satwani, Monica Bhatia, James H. Garvin, M. Brigid Bradley, Tracey Schonfeld, Lauren Harrison, Erin Morris, Joseph Schwartz, Lee Ann Baxter-Lowe, Mitchell S. Cairo
Journal: Blood (2009)
Fibromuscular Dysplasia of the Brachial Artery
Authors: Mistyann-Blue Miller, Demetrio R Flores
Journal: New England Journal of Medicine (2017)

A 68-year-old woman presented with exertional dyspnea and chest pain. She had undergone CABG 5 years earlier. Vascular examination revealed palpable radial pulses on both sides of the body; right brachial angiography revealed a “string of beads” pattern.