tbuckley/cabot-search huggingface dataset:
OC-100 <b>Lorec registry</b>–<b>interim analysis of operative technique and perineal wound healing outcomes after abdomino-perineal excision</b>
Authors: H Jones, S Crane, B Moran, C Cunningham
Journal: Gut (2015)

<h3>Introduction</h3> The LOREC perineal wound healing registry was developed to record data on abdomino-perineal excision (APE) for rectal cancer in colorectal units across the UK between 2012 and 2014 to understand current practice in operative techniques and patient outcomes. Initial interim results are reported. <h3>Method</h3> Surgeons wishing to participate received secure web-based access to the registry. Collected data included pre-operative staging, operative details, pathology, early outcome and follow-up at 12 months. <h3>Results</h3> Overall 43 units entered a total of 259 patients undergoing APE. These included 168 extralevator APE (ELAPE) procedures (65%) and 91 non-ELAPEs, comprising 73 ‘standard’ APE, 9 intersphincteric, 2 ischio-anal and 7 unspecified procedures. The ELAPE and non-ELAPE groups are compared. In the ELAPE group there were 120 males (71%) with a median age of 66 years (range 38–93). In the non-ELAPE group there were 64 males (70%) with a median age of 68 years (range 32–97). The perineal component was performed prone in 151 (90%) of the ELAPE group versus 13 (14%) of the non-ELAPE group. The coccyx was removed in 123 (73%) of the ELAPEs and 7 (8%) of the non-ELAPEs. In the ELAPE group primary skin closure for the perineal component was performed in 119 (71%) while in 34 (20%) a flap was used (13 VRAM, 9 local myocutaneous and 12 fascio-cutaneous flaps). In 15 cases (9%) the surgeons reported no closure. In 111 (66%) a mesh, generally biological, was used in perineal closure. Mesh was most commonly used where the closure was primary but 9 flap closures also used mesh. In the non-ELAPE group primary closure was more common, being used in 76 (84%) while in 5 (5%) a flap was used. In 10 cases (11%) the surgeons reported no closure. Mesh was used less frequently in non-ELAPEs, with only 30 (33%) using a mesh; the majority (57%) of these were non-biological. Primary healing was achieved in 29% of ELAPE patients, the majority of whom were closed primarily, compared to 9% in the non-ELAPE group. There was no difference in wound healing by 4 weeks and both groups had a small number of patients who took more than 3 months to heal completely. There was no significant difference in length of hospital stay for the two groups. There was one post-operative death in each group; a peritonitis of unknown cause in the ELAPE group and a GI bleed in the non-ELAPE group. <h3>Conclusion</h3> The LOREC registry has been a success in providing a summary of current practice and will be valuable in informing the design of future trials assessing APE techniques and reconstruction. In this series, ELAPE is performed in the majority of patients and primary closure with mesh appears to offer effective skin closure compared to flap. <h3>Disclosure of interest</h3> None Declared.
Renal Transplantation
Authors: Ronald D. Guttmann
Journal: New England Journal of Medicine (1979)

(Second of Two Parts)Renal TransplantationIn the current operation the donor kidney is placed in the iliac fossa, and the surgeon has the option of an end-to-end anastomosis of the renal artery with the hypogastric artery or, if this is not suitable, an end-to-side anastomosis with either the common or external iliac artery. The ureteral anastomosis is done at most centers by ureteroneocystostomy, since the post-transplantation complication of ureteral fistula is considerably less common after this procedure than with ureteroneopyelostomy or ureteroureterostomy.141 In a group of 142 living donors with minor renal abnormalities, 35 had abnormalities of the urinary . . .
Genistein-Induced Cell Differentiation and Protein-Linked DNA Strand Breakage in Human Melanoma Cells
Authors: K Kiguchi, A I Constantinou, E Huberman
Journal: Cancer Communications (1990)

Genistein, an in vitro inhibitor of topoisomerase II and tyrosine kinases, elicited an inhibition of growth and increased melanin content in five human melanoma cell lines, after six days of treatment at a concentration of 45 microM. In two lines examined more thoroughly, HO and SK-MEL-131, treatment with genistein also increased other markers of differentiation, including tyrosinase activity, reactivity with CF21 monoclonal antibody, and dendrite-like structure formation. The genistein-evoked increases in melanin content and tyrosinase activity were concentration- and time-dependent. Treatment of HO and SK-MEL-131 cells with 45 microM genistein for 24 hr or 60-600 microM genistein for only 1 hr resulted in an increase in protein-linked DNA strand breaks. Our results suggest an association between the genistein-evoked, protein-linked, DNA strand breaks and the genistein-induced differentiation of human melanoma cells.
SP0210 Functional Characterisation of Human Citrullinated Protein-Specific B-Cells
Authors: H.U. Scherer
Journal: Annals of the Rheumatic Diseases (2015)

In many autoimmune diseases, including rheumatoid arthritis (RA), the presence of autoantibodies represents a break of tolerance to self-antigens that has resulted in the generation of auto-reactive B cells. Frequently, this defective control of B cell auto-reactivity occurs prior to the onset of clinical symptoms of disease and marks one of the earliest detectable events of disease-related immune disturbance. Interestingly, studies of the last years have shown that auto-reactivity in healthy individuals is more frequent than previously anticipated, especially in the immature human B cell compartment. Defects in checkpoints that prevent the further maturation of auto-reactive B cell precursors have been postulated that favor the development of autoimmunity. However, once B cell precursors have passed these checkpoints, little is known about mechanisms that allow and control the maintenance of human auto-reactive B cell memory. In part, this is due to the fact that direct identification of auto-reactive B cells in humans has proven extremely difficult. In RA, anti-citrullinated protein antibodies (ACPA) represent highly disease-specific biomarkers found in the majority of patients. As ACPA have been implicated in disease pathogenesis, it is of crucial relevance to understand the underlying auto-reactive B cell response. In this context, direct antigen-specific identification and isolation of ACPA-producing B cells would allow a detailed phenotypic and functional characterization of the immune response to better understand its development and maintenance. We now successfully developed, for the first time, a tetramer-based method to identify citrullinated antigen-specific B cells in RA patients. This technique revealed that RA patients harbor a remarkable frequency of circulating memory B cells reactive with citrullinated antigens. This finding can be taken as a surprise, as one could expect that citrullinated antigen-specific B cells would constantly differentiate towards antibody secreting cells due to ubiquitous availability of citrullinated antigens, resulting in absence of specific memory B cells. Therefore, these cells and their functional characteristics are of particular interest and focus of the studies presented. Moreover, the therapeutic efficacy of B cell depletion by monoclonal antibodies targeting CD20 points to an important role of this compartment in RA disease pathogenesis. <h3>Disclosure of Interest</h3> None declared
The depressine Syndrome: a follow-up study of 130 professionals working overseas
Authors: L J King
Journal: American Journal of Psychiatry (1975)

A four-year follow-up of professional personnel who had been working overseas indicates that the depressive syndrome was the most common diagnosable psychiatric illness in this population. The study also shows that in this content the syndrome had a good prognosis. It therefore seems reasonable not to exclude persons with diagnosable depression from assignment abroad but, rather, to identify the syndrome and recommend necessary treatment.
An unusual complication of a proximally migrated stent: liver capsule rupture
Authors: Bülent Ödemis, Muhammet Akpinar, Erkin Oztas, Mustafa Kaplan, Ufuk Kuzu, Ertugrul Kayacetin
Journal: Endoscopy (2015)

Plastic stents are widely used for the management of biliary strictures, biliary stones, and cholangitis. Well-known complications associated with biliary stents are occlusion and migration. The frequency of migration is reported as 5 % to 10 % [1]. Migration occurs predominantly distally; however, proximal migration may also be seen.
OC-073 Impact of centralisation of o-g cancer surgery on the number of trusts performing surgery, trust volume and 30 and 90 day postoperative mortality
Authors: M Varagunam, D Cromwell, R Hardwick, O Groene
Journal: Gut (2015)

<h3>Introduction</h3> Centralisation of Oesophagogastric (OG) services were recommended in 2001, with centres serving a minimum population of 1 million.<sup>1</sup>Key recommendations were that cancer networks should be established with specialist centres performing curative surgery within each network, with a system of coordination between the specialist centres and other hospitals within the network. An overview of the impact of centralisation on the number of trusts, trust volume and mortality at the national level has not been done so far. <h3>Method</h3> We used the administrative data set Hospital Episode Statistics (HES) to determine the changes in numbers of trusts and trust volume from 2003 to 2013. Postoperative outcome of surgery (30 day and 90 day mortality) were determined from HES data linked to Office of National Statistics (ONS) data. <h3>Results</h3> We analysed data on 29,205 O-G operations. There was a steady decline in the number of trusts performing surgery and an increase in the median volume of patients in the trust from 2003 to 2013. There were 113 trusts performing surgery in 2003 which declined to 43 in 2013 with a corresponding increase in median volume of patients from 21 to 55. Mortality after 30 days and 90 days of surgery were 7.4% and 11.3% in 2003 which decreased to 2.5% and 4.6% in 2013 (Figure 1). The distribution of patient age and gender remained constant over time, but the proportion of oesophageal tumours increased from 55.0% in 2003 to 64.4% in 2013. <h3>Conclusion</h3> This is the first description of the changes in number of trusts and median trust volume that occurred from 2003 to 2013 at the national level using administrative data. There has been a reduction in the number of operating trusts and trust volume from 2003 to 2013 with better outcomes being achieved. Our data shows that the policy directive advocating a model of care involving centralised services has been successful in achieving the desired result in terms of better patient care. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Department of Health: Guidance on commisioning cancer services:Improving outcomes in upper gastrointestinal cancers. London: Department of Health, 2001
Infantile Spasms with Hypsarrhythmia
Authors: H A LADWIG, L VANSLAGER, J THOMAS, G SCHREINER, T MULLER, J I WAX
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Medical Treatment in South Africa
Authors: H Bloem
Journal: New England Journal of Medicine (1985)

SIR,-YOU may be one of those who plan your Christmas shopping well in advance, or one who leaves it until the very last minute.But however you set about this annual task I am asking you to spare a thought for those for whom Christmas brings little joy and probably some anxiety.I am referring to those beneficiaries of the Royal Medi- cal Benevolent Fund; some are doctors, some are widows with children, all are in need of our help and may be faced with prospect of having little with which to celebrate Christmas.The object of the Christmas appeal of the Royal Medical Benevolent Fund is to enable us to send financial gifts to our 780 beneficiaries this Christ- mas and also in Christmases to come.These are a special addition to the awards that we make throughout the year.The fund knows through the many letters received how much this little extra means, enabling those less fortunate than our- selves to have at least some joy and warmth at Christmas.
Creating an online atlas of Salmonella serotypes in Europe
Authors: M Rudbeck Jepsen, I Fisher, M Galle, H Bang, S Ethelberg
Journal: Eurosurveillance (2008)

Salmonellosis is a frequently occurring disease in Europe. Through their national surveillance systems, the European Union (EU) Member States collect a substantial amount of information on cases of salmonellosis, which may be used to gain new insights into the epidemiological characteristics of the many different Salmonella serotypes. One simple approach to this is by visualising the spatial distribution of the cases on maps.
ALK gene rearrangements in unselected caucasians with non-small cell lung carcinoma (NSCLC).
Authors: M. Varella-Garcia, Y. Cho, X. Lu, A. E. Barón, L. Terracciano, D. R. Camidge, P. A. Bunn, W. A. Franklin, F. Cappuzzo, R. C. Doebele
Journal: Journal of Clinical Oncology (2010)

10533 Background: Transforming rearrangements of the ALK gene have been reported in a subset of NSCLC, commonly fusing the ALK kinase domain with EML4 promoter but rarer fusion partners (TFG and KIF5B) have also been described. ALK is a valid clinical target based on phase I clinical data with dual ALK/MET inhibitor. We investigated the cytogenetic patterns of ALK rearrangements using FISH and the molecular and clinical characteristics associated with ALK+ in an unselected NSCLC population. Methods: Cohort included 447 NSCLC with previous EGFR and MET copy number gain (CNG) available; median age at diagnosis = 66 years, 83% male, 52% former and 35% current smokers; 52% of tumors were adenocarcinoma/BAC, stage I to IV was 37%, 22%, 27%, and 14%, respectively. Dual color FISH analyses were performed with ALK break-apart probe (Abbott Molecular) and 3 novel fusion probe sets specific for EML4-ALK, KIF5B-ALK and TFG-ALK. Results: Using the break apart probe, 12 patients (2.68%) were identified as ALK+. Multiple different cytogenetic patterns were observed, but virtually all carried the EML4-ALK fusion when specific probe sets were used. Using logistic regression analyses, higher odds were verified for ALK+ among males vs. females (p = 0.03), never vs. ever smokers (p = 0.005), adenocarcinoma vs. other histologies (p = 0.0013), and younger vs. older age (p = 0.08). No association was found between ALK+ and clinical stage, EGFR or MET CNG. There was no association between survival and ALK+ after adjusting for patient's gender, smoking history, histology and age (HR = 0.70; 95% CI 0.0256, 1.913, p = 0.48). Conclusions: In this large study of unselected Caucasian NSCLC patients, ALK+ was associated with male gender, never smoking status and adenocarcinoma histology suggesting these factors could be used to enrich ALK screened populations. The specific FISH probe sets identified EML4- ALK in different FISH patterns observed with the ALK rearrangement probe. ALK+ is distinct from EGFR and MET CNG, suggesting independent molecular mechanisms. ALK+ showed no significant prognostic impact, the observed favorable effect was unstable most likely due to the low number of ALK+. No significant financial relationships to disclose.
AB0640 Has Kawasaki Disease Lost its Articular Manifestations?
Authors: E.P. Alvarez Andrés, F. Rey, C. Peña, P. Collado, A. Rubio, M. Crespo, C. Calvo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Kawasaki Disease is a systemic vasculitis with an acute onset that affects primarily children under 5 years old. Even though its etiology is unknown, it can be preceded with viral infections. Its diagnosis is mainly clinical and its prognosis depends on cardiac complications. Acute arthritis was a very common finding in the pre-inmunoglobulins era. Nowadays with Inmunoglobulins treatment, it9s hard to find studies that mention articular manifestations. <h3>Objectives</h3> Our objective is to define arthritis prevalence in Kawasaki Disease at the time of diagnosis and its evolution. <h3>Methods</h3> It is a retrospective analysis of 42 patients with Kwasaki Disease, diagnosed between January 1988 and November 2013. Demographic, clinical, laboratory and treatment variables were analysed. The clinical evolution was analysed with a statistic program (SPSS.V.10). <h3>Results</h3> It was described a previous infection in 33,3%. Male children were predominant (57,1%), presenting diagnostic criteria: fever (100%), rash (92,9%), conjunctival inyection (78,6%), erythema of oral cavity (76,2%), swollen lymph node in the neck (71,4%), swelling and peeling in arms and legs (52,4 and 46,3% respectively). 8 patients had an altered echocardiogram (ectasy 14,3% and aneurism 4,8%). 50% of altered echocardiogram belonged to Incomplete Kawasaki. Seven patients (16%) presented arthritis at the onset (10 first days), mainly oligoarticular (57%), less than 4 joints, most of them ankles. We observed also, monoarticular arthritis (hip) in 2 patients (29%) and polyarticular in 1 patient (14%). Arthritis did not respond to Dalsy at first, but it responded to Inmunoglobulins IV, with ulterior effects. None of them had heart affectation. They have also a poor relationship with incomplete kawasaki. When admitted at the hospital: 14,3% had leukocytosis, 2,4% low platelets count, 42,9% hypoalbuminemia and 14,3% had an abnormal urianalysis. When talking about acute phase reactants: 92,9% presented an elevated CRP (88.1±58; [38-125]) and 78,6% and elevated ESR (69±30; [47.7- 92]). 71,4% of the patients were monitored afterwards, and 81% did not have any complications, non cardiac or articular. <h3>Conclusions</h3> Acute arthritis was unusual (16%), and with no ulterior complications. Cardiac affectation prevailed in incomplete kawasaki. Treatment with Inmunoglobulins IV and aspirin most likely prevents arthritis manifestations in Kawasaki Disease, therefore reducing monitorization with us. <h3>References</h3> Gong GW, et al. Arthritis presenting during the acute phase of Kawasaki disease. J Pediatr 2006:148:800-5 <h3>Disclosure of Interest</h3> None declared
SAT0629 Diagnostic Performance of High Resolution Trans-Thotacic Lung Ultrasonography in Pulmonary Involvement of Connective Lung Disease in Treatment with Cyclophosphamide
Authors: S. Tropea, M. Bentivegna, I. De Andres, A. Russo, P. Santonocito, E. Battaglia
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Interstitial involvement is a common manifestation in patient with connective tissue disorders, <h3>Objectives</h3> The aim of our study is to investigate the utility of modified TTUS scoring system compared con HRCT findings of in patients with connective tissue disease with pulmonary involvement in treatment with cyclophosphamide <h3>Methods</h3> 21 patients with a diagnosis of connective lung involvement in treatment with cyclophosphamide were examined with high resolution transthoracic ultrasonography for detecting of ultrasonography comet tail signe as a ultrasonographyc marker of lung involvement in interstitial in connective disease at time 0 and after 6 and 12 months after initiation of treatment with cyclophosphamide and the results of them were compared with high resolution computed tomography as gold standard method for diagnosis of lung involvemeant in this patients <h3>Results</h3> In comparation with HRCT as gold standard method, the sensitivity, specificity, positive and negative predictive value of TTUS was 75%, 89%, 95% and 52% respectively. <h3>Conclusions</h3> Modified TTUS can be useful imaging modality in the evalutation of even early stages of pulmonary involvement in connective lung disaease <h3>References</h3> Diagnostic Perfomance of lung ultrasound in the diagnosis of pneumonia: a bivariate meta-analysis Qian-Jing Hu*, Yong-Chun Shen*, Liu-Qun Jia, Shu-Jin Guo, Hong-Yu Long, Cai-Shuang Pang, Ting Yang, Fu-Qiang Wen Int J Clin Exp Med 2014;7(1):115-121 Guidelines for the diagnosis and treatment of pulmonary hypertension Nazzareno Galiè (Chairperson) (Italy)*; Marius M. Hoeper (Germany); Marc Humbert (France); Adam Torbicki (Poland); Jean-Luc Vachiery (France); Joan Albert Barbera (Spain); Maurice Beghetti (Switzerland); Paul Corris (UK); Sean Gaine (Ireland); J. Simon Gibbs (UK); Miguel Angel Gomez-Sanchez (Spain); Guillaume Jondeau (France); Walter Klepetko (Austria)Christian Opitz (Germany); Andrew Peacock (UK); Lewis Rubin (USA); Michael Zellweger (Switzerland); Gerald Simonneau (France) <h3>Disclosure of Interest</h3> None declared
Further Observations on the Genetic Nature of Gastric Cancer in Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Leonell C. Strong
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Further Observations on the Genetic Nature of Gastric Cancer in Mice Get access Leonell C. Strong Leonell C. Strong associate professor Department of Anatomy, Yale University School of Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 305–308, https://doi.org/10.1093/jnci/7.5.305 Published: 01 April 1947
The Effect of Injections of Tumor Fractions on Liver Catalase Activity of Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Robert E. Greenfield, Alton Meister
Journal: JNCI Journal of the National Cancer Institute (1951)

The Effect of Injections of Tumor Fractions on Liver Catalase Activity of Mice Get access Robert E. Greenfield, Robert E. Greenfield Search for other works by this author on: Oxford Academic PubMed Google Scholar Alton Meister Alton Meister National Institutes of Health, National Cancer Institute, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 5, April 1951, Pages 997–1005, https://doi.org/10.1093/jnci/11.5.997 Published: 01 April 1951 Article history Received: 02 January 1951 Published: 01 April 1951