tbuckley/cabot-search huggingface dataset:
A 28 year old postpartum woman with right sided chest discomfort: case outcome
Authors: Girish Dwivedi, Sajad Ahmed Hayat, Andonis G Violaris, Roxy Senior
Journal: BMJ (2006)

Four weeks ago we described the case of Mrs Patel, a 28 year old postpartum woman with atypical right sided chest pain (18 February BMJ 2006;332: 406. A treadmill exercise test was non-diagnostic but stress echocardiography showed reduced systolic wall thickening (25 February BMJ 2006;332: 471).

Coronary angiography showed she had a critical lesion in the proximal left anterior descending artery with an associated thrombus (fig 1). The circumflex and right coronary artery had plaque disease but no flow limiting …
Human amniotic fluid stem cells labeled with up-conversion nanoparticles for imaging-monitored repairing of acute lung injury
Authors: Yunyun Xu, Jian Xiang, He Zhao, Hansi Liang, Jie Huang, Yan Li, Jian Pan, Huiting Zhou, Xueguang Zhang, Jiang Huai Wang, Zhuang Liu, Jian Wang
Journal: Biomaterials (2016)
Allergic conjunctivitis due to diazepam
Authors: E G Lutz
Journal: American Journal of Psychiatry (1975)

The author reports on four patients, all women, who developed conjunctival hypersensitivity during diazepam treatment. This hypersensitivity is self-limited after diazepam treatment is discontinued. The author suggests that conjunctival hypersensitivity could be mistakenly attributed to contact lens irritation rather than to diazepam.
The time to progression ratio: a new individualized volumetric parameter for the early detection of clinical benefit of targeted therapies
Authors: G.A. Cirkel, F. Weeber, S. Bins, C.G.M. Gadellaa-van Hooijdonk, E. van Werkhoven, S.M. Willems, M. van Stralen, W.B. Veldhuis, I. Ubink, N. Steeghs, M.J. de Jonge, M.H.G. Langenberg, J.H.M. Schellens, S. Sleijfer, M.P. Lolkema, E.E. Voest
Journal: Annals of Oncology (2016)
Quantitative Studies on Rous Sarcoma Virus. IV. An Investigation of the Nature of “Noninfective” Tumors Induced by Low Doses of Virus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: A M PRINCE
Journal: JNCI Journal of the National Cancer Institute (1959)
Immunologic, Biochemical, and Ultrastructural Characterization of the Leukemia Cell in F344 Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: P C Stromberg, J L Rojko, L M Vogtsberger, C Cheney, R Berman
Journal: JNCI Journal of the National Cancer Institute (1983)

Immunologic, biochemical, and morphologic characteristics of the mononuclear cell from the leukemia of F344 rats were determined. The cells were morphologically similar to large granular lymphocytes (LGL). Surface marker analysis revealed Fc gamma receptors, no Fc gamma receptor or complement receptor activity, and an inability to spontaneously rosette guinea pig erythrocytes. Leukemia cells also had a surface immunoglobulin that hemagglutinated normal rat erythrocytes. The surface immunoglobulin and Fc gamma receptors dissociated from the cell after 2 hours of in vitro incubation, but Fc gamma receptor activity was reexpressed after 6 hours of in vitro incubation. Cells were capable of adherence to glass surfaces but had a low capacity for phagocytosis of latex beads. Cytochemical analysis revealed a consistent, strongly positive reaction for esterase that was sensitive to NaF. The cytochemical profile of the leukemia cell was similar to that described for LGL.
Pharmacological management of nonalcoholic fatty liver disease
Authors: Diana Barb, Paola Portillo-Sanchez, Kenneth Cusi
Journal: Metabolism (2016)

<h2>Abstract</h2> Nonalcoholic fatty liver disease (NAFLD) affects one-third of the population and two-thirds of patients with obesity or type 2 diabetes (T2DM). Its more aggressive form is known as nonalcoholic steatohepatitis (NASH) and is characterized by hepatocyte necrosis, inflammation and often fibrosis. The presence of fibrosis indicates a more aggressive course and may lead to cirrhosis. Premature mortality in NASH is related to both hepatic (cirrhosis and hepatocellular carcinoma) and extra-hepatic complications, largely cardiovascular disease (CVD). Many therapeutic agents have been tested, but still none approved specifically for NASH. Treatment of NAFLD includes aggressive management of diabetes and cardiovascular risk factors, although the role of controlling hyperglycemia per se in patients with T2DM and NASH remains unknown. Agents tested with some success in non-diabetic patients with NASH include pioglitazone, liraglutide, vitamin E and to a lesser degree, pentoxiphylline. In patients with T2DM and NASH only pioglitazone has shown to significantly improve liver histology, with only a handful of patients with diabetes having been studied with other modalities. This review focuses on available agents for NASH to assist clinicians in the management of these complex patients. Many novel compounds are being studied and will likely make combination therapy for NASH a reality in the future.
Sex-Linked Rejection of Normal and Neoplastic Tissue. I. Distribution and Specificity&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: E. J. Eichwald, C. R. Silmser, I. Weissman
Journal: JNCI Journal of the National Cancer Institute (1958)

Sex-Linked Rejection of Normal and Neoplastic Tissue. I. Distribution and Specificity Get access E. J. Eichwald, E. J. Eichwald Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar C. R. Silmser, C. R. Silmser Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Weissman I. Weissman Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 3, March 1958, Pages 563–575, https://doi.org/10.1093/jnci/20.3.563 Published: 01 March 1958 Article history Received: 16 September 1957 Published: 01 March 1958
Induction of Tumors in Mice Following Intrasplenic or Intrahepatic Transplantation of Fetal Skin, Muscle, or Stomach with Methylcholanthrene&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Michael Klein
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Induction of Tumors in Mice Following Intrasplenic or Intrahepatic Transplantation of Fetal Skin, Muscle, or Stomach with Methylcholanthrene Get access Michael Klein Michael Klein Cancer Research Laboratory, University of Florida, Gainesville, Fla. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 5, April 1954, Pages 1137–1145, https://doi.org/10.1093/jnci/14.5.1137 Published: 01 April 1954 Article history Received: 12 November 1953 Published: 01 April 1954
Feasibility and toxicity report from a phase II study of accelerated twice-daily (BDRT) versus high dose once-daily thoracic radiotherapy (ODRT) with concurrent chemotherapy for limited stage small cell lung cancer (LS-SCLC)
Authors: C. Faivre-Finn, F. Blackhall, N. Thatcher, P. Taylor, L. Ashcroft, C. Rowbottom, P. Lorigan
Journal: Journal of Clinical Oncology (2008)

7583 Background: Early concurrent twice-daily (BD) chemo-radiotherapy (BDRT) is a standard of care for LS-SCLC (1) but logistical issues and high grade 3+ esophagitis rate of 32% have impeded widespread adoption. Toxicity of BDRT (45 Gy in 30 fractions BD) may be less with modern radiotherapy (RT) techniques. ODRT (66 Gy in 33 daily fractions) may also be less toxic with better local control. As an international randomized phase III trial of BDRT versus ODRT (CONVERT C17052/A8152) starts in Europe we report on phase II feasibility and toxicity data for these regimens. Methods: Patients (pts) with LS-SCLC, PS 0–1 and suitable for radical radiotherapy received cisplatin (P), 60 mg/m2 IV d1 with etoposide (E) 120 mg/m2 IV d1–3, q3 wks x 4 cycles with concurrent RT (3D conformal without elective nodal irradiation) from cycle 2. A pilot study of BDRT enrolled 6 pts and then a phase II trial randomized 21 pts to BDRT or ODRT. Common toxicity criteria 3.0 was used. Results: For 27 patients (ODRT n=11; BDRT n=16) the median age was 60 (28- 78) yrs, 63% were male and 74% were PS1. 26 pts completed all planned PE; 1 pt received carboplatin and etoposide from cycle 2. All patients received the full prescribed dose of RT. At a median follow up of 10.5 months, the median survival for all pts was 16.9 months (3.1, 30.6) and 1 year survival was 68%. The commonest grade 3 non-hematological toxicity was fatigue in 16% of patients; 13 pts (48%) experienced acute grade 2 esophagitis and only 1 pt (4%) had acute grade 3 esophagitis. One patient experienced acute grade 2 pneumonitis (4%). To date there are no grade 3 or 4 late radiation toxicities. The commonest grade 4 acute hematological toxicity was neutropenia (n=15, 55%) and 31% of patients required antibiotics. GCSF was prescribed as secondary prophylaxis to 38% of patients. No toxic deaths have occurred. Conclusions: Our preliminary findings are that these regimens are feasible and well tolerated with a lower than expected rate of acute grade 3+ esophagitis. The CONVERT trial will evaluate these regimens in 532 patients for the primary endpoint of survival. No significant financial relationships to disclose.
Case 48-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Alexander Leaf, Benjamin Castleman
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 60-year-old man was admitted to the hospital because of dyspnea.He was well until four years before admission, when he began to notice easy bruising, bleeding of the gums and multiple cutaneous nodules. Three years before entry an iron-deficiency anemia was found; stool specimens gave + tests for occult blood, but no bleeding source was located. An x-ray film of the chest was normal. One year before admission an x-ray film of the chest was interpreted as showing interstitial fibrosis (Fig. 1). Multiple films of the chest in succeeding months disclosed areas of atelectasis and questionable . . .
Abstract P5-09-07: Using the power of the internet to deliver breast teaching in Africa
Authors: AM Shaaban, F Abdulkareem, O Rotimi
Journal: Cancer Research (2016)

Abstract Introduction: Delivering high quality breast teaching to African countries is of utmost importance. Our previous audit of breast cancer reporting in Africa has identified areas that would benefit from teaching and education. However, time and resource issues limit the ability to deliver teachings to a large number of African pathologists in person. Method As part of a comprehensive national in house teaching for senior trainees in Nigeria, a distant module of teaching was delivered by a team of UK pathologists using a freely available internet application. Results Distant teaching formed part of a two week residential postgraduate histopathology course that was designed for trainees preparing for their exit Histopathology exam. Sixty African pathologists attended the teaching. Previous auditing of breast cancer reporting indicated the need for education on macroscopic specimen handling, typing and grading of breast cancer. Other topics included an update on inflammatory breast cancer which has a high incidence in Africa and columnar cell lesions that are increasingly being encountered by African pathologists in the context of breast screening. A set of anonymous virtual slides were scanned and distributed to delegates before the course date. Teaching was delivered using Skype application that only required a computer with internet access at the UK and Nigeria. We utilised video-conferencing which allowed trainees to see their lecturers and vice versa. The new data sharing facility of the application allows simultaneous sharing of Power Point presentations, with annotation which facilitates interactive discussion. A slide seminar using the previously circulated virtual slides, covering areas of diagnostic challenges morphologically and by immunohistochemistry was also delivered. An approach to diagnosing these lesions was delivered with re-focussing on tumor typing and grading. Participants were able to ask questions and interact with the UK-based tutors thorough the sessions. The feedback collected from attendees was excellent. Conclusion Distant teaching using freely available internet applications is a valuable, time and cost effective method that allows sharing educational material including lectures and slide seminars in an interactive manner. It is particularly useful in delivering teaching to resource-poor countries. Citation Format: Shaaban AM, Abdulkareem F, Rotimi O. Using the power of the internet to deliver breast teaching in Africa. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-09-07.
Effect of Temporary Ovarian Suppression on Chemotherapy-Induced Amenorrhea, Pregnancy, and Outcome
Authors: Pamela N. Munster
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Detection of EGFR alterations in circulating tumor DNA of non-small cell lung cancer by digital PCR and Next Generation Sequencing
Authors: G. Malpeli, M. Simbolo, S. Pilotto, R.T. Lawlor, U. Peretti, G. Bonizzato, S. Kinspergher, R. Ferrara, C. Cantu', M. Caccese, G. Tortora, E. Bria, A. Scarpa
Journal: Annals of Oncology (2015)
Abstract P1-15-04: Irriversible chemotherapy-induced alopecia in breast cancer patient
Authors: S Kim, HS Park, JY Kim, S Nam, GM Kim, JH Sohn, SI Kim
Journal: Cancer Research (2016)

Abstract Introduction Patients with breast cancer who received chemotherapy have distressing side effects such as mucositis, alopecia, gastritis, and BM suppression. Chemotherapy-induced alopecia(CIA) is one of considerable psychological events in self-esteem in patients with breast cancer, but the possibility of irreversible alopecia is often overlooked by physician. We investigated clinical characteristics of CIA and prevalence of irreversible severe hair loss in patient with breast cancer who received chemotherapy. Methods We conducted a survey to collect demographic information about CIA with 150 breast cancer patients who had passed at least 6 months since their last day of chemotherapy from February 2015 to May 2015 in Yonsei Cancer Center. We obtained clinical information as age, elapsed time from end of chemotherapy, chemotherapy regimen, and other adjuvant therapy using their electrical medical records. We compared irreversible CIA characters between anthracycline and cyclophosphamide (AC) and taxane based regimen groups. The severe alopecia was defined as the hair density loss over 50% compared to the hair density before chemotherapy. Results The mean age at chemotherapy was 48 years old (±17.3) and the mean elapsed time after chemotherapy was 37 months (±9.5) in total patients. Remnant alopecia was reported in 71 patients (47.3%). Wig or hat were used in 39 patients (26.0%). The mean satisfaction score with a five-point scale was 4 in patients without alopecia or hair character change and 2.2 in patients with irreversible alopecia (p&amp;lt;0.001). The severe irreversible hair loss was complained by the 12 (8.2%) patients. AC and taxane based chemotherapy were carried out in 65 and 85 patients, respectively. In AC group, remnant alopecia was shown in 18 patients (27.7%), and more than a half of patients in taxane group, 53 patients (62.4%), showed remnant alopecia (p&amp;lt;0.001). While only five patients (7.8%) in AC group suffered for severe hair loss, 26 patients (31.3%) in taxane group were affected by severe hair loss (p=0.001). The mean satisfaction level of hair status in patients in taxane group was 2.5 as compared to 3.6 in those in AC group (p&amp;lt;0.001). Conclusion Contrary to general expectation, About a half of breast cancer patients who received chemotherapy complained of irreversible hair loss even though at least 6 months has elapsed since the end of chemotherpy. In particular, patients with taxane based chemotherapy had more irreversible and severe alopecia than those with AC chemotherapy. Citation Format: Kim S, Park HS, Kim JY, Nam S, Kim GM, Sohn JH, Kim SI. Irriversible chemotherapy-induced alopecia in breast cancer patient. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-15-04.
Whipple’s Disease Can be Diagnosed Using Paraffin-Embedded Specimens from the Ileum Obtained During Ileocolonoscopy
Authors: K-A Ung, G Havel, B Claesson, L V von Stedingk, H-S Hanson, G Midhagen
Journal: Endoscopy (2003)

We present a case of Whipple’s disease diagnosed by biopsy of the terminal ileum. Light and electron microscopy revealed typical changes. Polymerase chain reaction (PCR) analysis performed on DNA from paraffin blocks demonstrated bacterial ribosomal DNA [1]. A 57-year-old previously healthy woman presented with malabsorption with 20 stools per day. Ileocolonoscopy and gastroscopy showed normal findings. Biopsies were obtained from the ileum, colon and duodenum. Light microscopy (Figure [1]) suggested Whipple’s disease and electron microscopy (Figure [2]) demonstrated the bacteria. DNA from ileal paraffin blocks showed a PCR-product demonstrating 100 % homology with the Tropheryma whippelii 16S rRNA gene. Intravenous cephalosporin was administered for 1 week followed by long-term treatment with trimethoprim 160 mg and sulfamethoxazole 800 mg b. i. d. Normalization of weight and stools ensued, and the patient was in excellent condition after 4 months. After 2 years of treatment biopsies showed no Tropheryma whippelii DNA detectable by PCR. Whipple’s disease is lethal unless treated. The diagnosis has usually been based on duodenal biopsies. The value of ileoscopy in gastrointestinal diseases has been evaluated in a few studies [2]. It is the primary investigation for suspected ileal Crohn’s disease and may reveal less frequently occurring diseases, such as villous atrophy, lymphoma, carcinoid, typhoid ulcer, NSAID-associated ulcer and tuberculosis. Our case adds Whipple’s disease to this list. Whether biopsies from the terminal ileum are sufficient to discover all cases of Whipple’s disease cannot be concluded either from this report or from the literature. On the other hand, since the lesion has been reported to be diffuse in the jejunum but patchy in the duodenum [3], duodenal biopsies might not reveal the diagnosis; thus, there is a rationale for performing ileal biopsies to make a diagnosis of Whipple's disease. Paraffin-embedded specimens can be used to provide DNA for diagnosis by PCR analysis, eliminating the need for a repeat endoscopy to obtain fresh tissue.
Computerized tomography in patients with tardive dyskinesia
Authors: A J Gelenberg
Journal: American Journal of Psychiatry (1976)

The author reviews the results of computerized tomography performed on eight patients with tardive dyskinesia to determine whether there was permanent structural damage. No significant abnormalities were found. Although it may not be useful in routine workups, this new noninvasive technique might be helpful in differential diagnosis, and its increasing sophistication may suggest further research on tardive dyskinesia.
Radiation Therapy for Breast Cancer
Authors: Dimitrios H Roukos
Journal: New England Journal of Medicine (2009)

Radiation therapy represents an important aspect of breast cancer treatment.Application of irradiation reduces the incidence of local disease recurrence and improves overall survival of breast cancer patients.Studies have shown that adjuvant irradiation after breast-conserving surgery has the same result as a mastectomy, so adjuvant radiotherapy enables sparing surgery in breast cancer patients.We will review the mechanisms, indications and methods of the whole breast irradiation, as a standard approach to the treatment.The main directions and controversies of today's research will be shown, primarily the introduction of hypofractionation, i.e. distribution of high daily doses of irradiation in a shorter overall period of treatment, as well as the application of partial breast irradiation, i.e. irradiation of a part of the breast instead of postoperative irradiation of the whole breast.Further molecular analysis of tumor biology will lead to the new prognostic and predictive parameters, and thus to the further personalization in the fi eld of breast cancer radiotherapy.
Lymphogranuloma venereum: a hidden emerging problem, Barcelona, 2011
Authors: H Vargas-Leguas, P Garcia de Olalla, M Arando, P Armengol, M J Barberá, M Vall, A Vives, G Martín-Ezquerra, M Alsina, J Blanco, C Muñoz, E Caballero, A Andreu, M Ros, P Gorrindo, A Dominguez, J A Caylà
Journal: Eurosurveillance (2012)

From the beginning of 2007 until the end of 2011, 146 cases of lymphogranuloma venereum (LGV) were notified to the Barcelona Public Health Agency. Some 49% of them were diagnosed and reported in 2011, mainly in men who have sex with men. Almost half of them, 32 cases, were reported between July and September. This cluster represents the largest since 2004. This article presents the ongoing outbreak of LGV in Barcelona.