tbuckley/cabot-search huggingface dataset:
Charge-reversal nanoparticles: novel targeted drug delivery carriers
Authors: Xinli Chen, Lisha Liu, Chen Jiang
Journal: Acta Pharmaceutica Sinica B (2016)

Spurred by significant progress in materials chemistry and drug delivery, charge-reversal nanocarriers are being developed to deliver anticancer formulations in spatial-, temporal- and dosage-controlled approaches. Charge-reversal nanoparticles can release their drug payload in response to specific stimuli that alter the charge on their surface. They can elude clearance from the circulation and be activated by protonation, enzymatic cleavage, or a molecular conformational change. In this review, we discuss the physiological basis for, and recent advances in the design of charge-reversal nanoparticles that are able to control drug biodistribution in response to specific stimuli, endogenous factors (changes in pH, redox gradients, or enzyme concentration) or exogenous factors (light or thermos-stimulation).
PTH-338 Postoperative troponin i elevation in patients undergoing major abdominal surgery
Authors: S Duff, A Macdonald, J Sarma, S Lavarello Munoz
Journal: Gut (2015)

<h3>Introduction</h3> In the UK, there is an ageing general surgical population with increasing comorbidity. Most studies evaluating postoperative elevation in troponin-I have focussed on surgery in individuals known or suspected to be at high risk of atherosclerotic disease. We aimed to determine the rates of postoperative elevation of troponin-I in patients following elective and emergency major abdominal surgery. Early identification of these patients is vital as this may allow cardiac risk modification improving long-term survival. <h3>Method</h3> One hundred patients were recruited. Demographic data was collected. Troponin-I was measured on day one and two postoperatively. If a raised troponin-I level was detected on either blood sample, an electrocardiogram was performed, the patient questioned about the presence of any symptoms and a prompt cardiology consultation was obtained. <h3>Results</h3> Fifty-five men and forty-five women were recruited (mean age 70.3, range 45–90). Thirteen of the hundred patients (13%) had postoperatively elevated troponin-I levels on day 1 or 2. Postoperative troponin-I elevation was associated with an increased mean age (P = 0.012) and with increasing CEPOD category of surgery (P = 0.009). No statistically significant difference was seen between groups for P-POSSUM scores of morbidity (P = 0.07) or mortality (P = 0.067). <h3>Conclusion</h3> Elevated postoperative troponin-I levels were identified in 13% of general surgical patients undergoing major abdominal surgery. All elevations were asymptomatic and not associated with any cardiological symptoms or ECG abnormality. Elderly patients undergoing emergency surgery are a high-risk group for perioperative cardiac damage which may contribute to the increased morbidity and risk of emergency general surgery. <h3>Disclosure of interest</h3> None Declared.
Massive Venous Hemorrhage after Bilateral Internal Iliac Artery Ligation following Retropubic Prostatectomy
Authors: M.S. Rao, K.M.K. Rao, S. Vaidyanathan, L.J. Rajendran, C.L. Subudhi, V.V. Shrikhande, B.C. Bapna, S. Suri
Journal: European Urology (1978)
Relationship between the Hairless Gene and Susceptibility to Induced Pulmonary Tumors in Mice
Authors: W. E. Heston, Margaret K. Deringer
Journal: JNCI Journal of the National Cancer Institute (1949)

Relationship between the Hairless Gene and Susceptibility to Induced Pulmonary Tumors in Mice Get access W. E. Heston, W. E. Heston principal geneticist National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer Margaret K. Deringer biologist National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 119–124, https://doi.org/10.1093/jnci/10.1.119 Published: 01 August 1949 Article history Received: 04 April 1949 Published: 01 August 1949
Psychotherapy of the medically ill
Authors: T B Karasu
Journal: American Journal of Psychiatry (1979)

The author assesses the current status of psychotherapy with medically ill patients. He reviews the special problems of psychological treatment for this population; the respective rationales for the utilization of various psychotherapeutic approaches including psychoanalysis, dynamic psychotherapy, and family and group therapy; and the results of case reports and research studies. The author identifies specific areas of future investigation and research, elucidates some specific implications for clinical practice, and recommends more critical exploration of the role of psychotherapy in the treatment of the medically ill.
Synthesis and Preclinical Evaluation of Sulfonamido-based [<sup>11</sup>C-<i>Carbonyl</i>]-Carbamates and Ureas for Imaging Monoacylglycerol Lipase
Authors: Lu Wang, Wakana Mori, Ran Cheng, Joji Yui, Akiko Hatori, Longle Ma, Yiding Zhang, Benjamin H. Rotstein, Masayuki Fujinaga, Yoko Shimoda, Tomoteru Yamasaki, Lin Xie, Yuji Nagai, Takafumi Minamimoto, Makoto Higuchi, Neil Vasdev, Ming-Rong Zhang, Steven H. Liang
Journal: Theranostics (2016)

Monoacylglycerol lipase (MAGL) is a 33 kDa member of the serine hydrolase superfamily that preferentially degrades 2-arachidonoylglycerol (2-AG) to arachidonic acid in the endocannabinoid system.Inhibition of MAGL is not only of interest for probing the cannabinoid pathway but also as a therapeutic and diagnostic target for neuroinflammation.Limited attempts have been made to image MAGL in vivo and a suitable PET ligand for this target has yet to be identified and is urgently sought to guide small molecule drug development in this pathway.Herein we synthesized and evaluated the physiochemical properties of an array of eleven sulfonamido-based carbamates and ureas with a series of terminal aryl moieties, linkers and leaving groups.The most potent compounds were a novel MAGL inhibitor, N- ((1-(1H-1,2,4-triazole-1-carbonyl)piperidin-4-yl) methyl)-4-chlorobenzenesulfonamide (TZPU; IC 50 = 35.9nM), and the known inhibitor 1,1,1,3,3,3-hexafluoropropan-2-yl 4-(((4-chlorophenyl)sulfonamido) methyl)piperidine-1carboxylate (SAR127303; IC 50 = 39.3 nM), which were also shown to be selective for MAGL over fatty acid amide hydrolase (FAAH), and cannabinoid receptors (CB1 & CB2).Both of these compounds were radiolabeled with carbon-11 via [ 11 C]COCl 2 , followed by comprehensive ex vivo biodistribution and in vivo PET imaging studies in normal rats to determine their brain permeability, specificity, clearance and metabolism.Whereas TZPU did not show adequate specificity to warrant further evaluation, [ 11 C]SAR127303 was advanced for preliminary PET neuroimaging studies in nonhuman primate.The tracer showed good brain permeability (ca. 1 SUV) and heterogeneous regional brain distribution which is consistent with the distribution of MAGL.
Hematopoietic progenitor cells from patients with adult T-cell leukemia- lymphoma are not infected with human T-cell leukemia virus type 1
Authors: K Nagafuji, M Harada, T Teshima, T Eto, Y Takamatsu, T Okamura, M Murakawa, K Akashi, Y Niho
Journal: Blood (1993)
The Treatment of Spontaneous Tumors of the Dog and Cat with a Filtrate from a Tissue Lysate&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: W S LIVINGSTON
Journal: JNCI Journal of the National Cancer Institute (1958)

The Treatment of Spontaneous Tumors of the Dog and Cat with a Filtrate from a Tissue Lysate Get access W. Steele Livingston, D.V.M. W. Steele Livingston, D.V.M. Lucille Scott Livingston Laboratories, North Hollywood, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 2, February 1958, Pages 245–307, https://doi.org/10.1093/jnci/20.2.245 Published: 01 February 1958 Article history Received: 20 May 1957 Published: 01 February 1958
SP0244 Genetics of Psoriatic Arthritis
Authors: A. Barton
Journal: Annals of the Rheumatic Diseases (2015)

Twin and family studies suggest that the genetic contribution to psoriatic arthritis (PsA) is higher than psoriasis, leading to the expectation that there will be genetic loci that contribute to the risk of PsA over and above psoriasis alone. However, few PsA-specific loci have yet been identified. There are several reasons, including lack of power of many studies conducted, to date, and the difficulty of separating pure psoriasis from PsA as many patients with psoriasis may have undiagnosed PsA. Nonetheless, with recent better powered genetic studies, PsA-specific loci are starting to emerge. Examples include the HLA region in which HLA-B27 appears to be primarily associated with PsA whilst HLA-C6 shows a primary association with psoriasis. Outside the HLA gene region, a locus on chromosome 5q31 also shows evidence of association with PsA and not psoriasis. The challenge now remains to identify the genes involved as they could be potential targets for future drug development or to allow screening of patients with psoriasis to identify those at higher risk of developing PsA. <h3>Disclosure of Interest</h3> None declared
COMPARISON OF CLINICAL OUTCOMES BETWEEN BIORESORBABLE VASCULAR STENTS VERSUS CONVENTIONAL DRUG-ELUTING AND METALLIC STENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: Maciej Banach, Maria Corina Serban, Amirhossein Sahebkar, Hector M. García-García, Dimitri P. Mikhailidis, Seth Martin, Brie Daniel, Jacek Rysz, Peter Toth, Steven Jones, Rani Hasan, Svetlana Mosteoru, Mahmoud Al Rifai, Michael Pencina, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2016)
THU0207 Comparative Analysis of the Effectiveness of anti-TNF Therapies in Non-Radiographic Axial Spondyloarthritis Using Novel Statistical Techniques: Table 1.
Authors: A. Benedict, J. Ishak, P. Gal, I. Proskorovsky, J.C. Cappelleri, T. Everiss, H. Jones, R. Hughes, A. Jenkins
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The anti-tumor necrosis factor (TNF) agents adalimumab (ADA), certolizumab pegol (CZP), and etanercept (ETN) are approved in Europe for the treatment of severe non-radiographic axial spondyloarthritis (nr-axSpA). The efficacy of these agents has been demonstrated against placebo in randomised controlled trials,<sup>1-3</sup> but no head-to-head studies have been conducted. Moreover, the results from a typical network meta-analysis may be misleading in nr-axSpA due to possible heterogeneity between studies caused by differences in populations. <h3>Objectives</h3> To assess the relative effectiveness of ETN vs ADA and CZP in axSpA (primarily nr-axSpA) populations using the novel matching-adjusted indirect comparison (MAIC) and simulated treatment comparison (STC) statistical techniques to adjust for between-population differences in clinical characteristics across studies. <h3>Methods</h3> Pooled index trials of ETN (ongoing EMBARK<sup>3</sup> [nr-axSpA] + 314-EU<sup>4</sup> [ankylosing spondylitis]) were compared with the ABILITY-1<sup>1</sup> and RAPID-axSpA<sup>2</sup> trials of ADA and CZP. Differences in changes in BASDAI and BASFI from baseline to week 12 for ETN vs ADA and CZP were derived adjusting for baseline characteristics (via weighting in MAIC and prediction in STC). To adjust for differences in characteristics that could not be matched and missing variables, differences between placebo arms were also measured to derive the study effect; study effect was subsequently subtracted from the adjusted estimate of relative treatment effect to account for possible residual confounding or study effects. <h3>Results</h3> Incremental changes in BASDAI and BASFI for ETN compared with ADA and CZP are shown (table). The analyses show similar and not statistically significantly different changes in BASDAI and BASFI for ETN and comparators at week 12. Similar or identical treatment results were observed using MAIC and STC. <h3>Conclusions</h3> Based on analyses using MAIC and STC methods, etanercept was not different in efficacy from ADA and CZP in patients with axSpA. <h3>References</h3> Sieper J, et al. Ann Rheum Dis. 2013;72:815-22. Landewe R, et al. Ann Rheum Dis. 2014;73:39-47. Dougados M, et al. Arthritis Rheumatol. 2014;66:2091-102. van der Heijde D, et al. Ann Rheum Dis. 2006;65:1572-7. <h3>Disclosure of Interest</h3> A. Benedict Consultant for: Pfizer Ltd, J. Ishak Consultant for: Pfizer Ltd, P. Gal Consultant for: Pfizer Ltd, I. Proskorovsky Consultant for: Pfizer Ltd, J. C. Cappelleri Shareholder of: Pfizer Inc, Employee of: Pfizer Inc, T. Everiss Shareholder of: Pfizer Inc, Employee of: Pfizer Inc, H. Jones Shareholder of: Pfizer Inc, Employee of: Pfizer Inc, R. Hughes Employee of: Pfizer Inc, A. Jenkins Shareholder of: Pfizer Inc, Employee of: Pfizer Inc
PWE-133 Vascular inflammation is associated with endothelial dysfunction and oxidative stress in patients with non-alcoholic fatty liver disease
Authors: L Chong, D Laight, AJ Fowell, RJ Aspinall, M Cummings
Journal: Gut (2015)

<h3>Introduction</h3> Individuals with non-alcoholic fatty liver disease (NAFLD) have a significantly increased risk of cardiovascular (CV) disease independent of other cardiometabolic risk factors. We explored the relationship between endothelial function, oxidative stress, vascular inflammation and insulin resistance in patients with NAFLD. <h3>Method</h3> Patients with proven NAFLD but without cirrhosis were recruited into the study and the following parameters were assessed: Endothelial function – change in reflective index post salbutamol using digital plethysmography, urine albumin:creatinine ratio, plasma vascular cell adhesion molecule-1 (VCAM-1) and plasma cyclic guanosine monophosphate (cGMP) Oxidative stress – blood glutathione ratio (GSH:GSSG), plasma total anti-oxidant status and plasma lipid hydroperoxides Inflammation – highly-sensitive plasma CRP Insulin resistance – HOMA-IR <h3>Results</h3> We studied 42 patients: 31 males and 11 females. We found 79% had T2DM or impaired fasting glucose. Mean age was 58 ± 8 years, BMI 33.2 ± 5.5 kg/m<sup>2</sup>, BP 133/82 ± 12/7 mmHg, duration of NAFLD diagnosis 1.0 ± IQR 3.4 years, HbA1c 53 ± 13 mmol/mol, total cholesterol 4.43 ± 1.14 mmol/l, HDL 1.06 ± 0.32 mmol/l, LDLc 2.51 ± 1.02 mmol/l, and triglycerides 1.93 ± 0.85 mmol/l. There was moderate correlation between VCAM-1 and hsCRP (Spearman’s rho=0.392,<i>p = 0</i>.01); moderate correlation between hsCRP and blood glutathione ratio (Spearman’s rho=0.325, p = 0.04) and moderate correlation between HOMA-IR and aspartate aminotransferase [AST] (Spearman’s rho=0.489, <i>p = 0</i>.001). <h3>Conclusion</h3> Markers of both vascular (VCAM-1) and systemic low grade inflammation (hsCRP) were associated with evidence of endothelial dysfunction and oxidative stress, whilst insulin resistance was associated with AST in non-cirrhotic patients with NAFLD. VCAM-1 as a marker of endothelial activation may be a potential CV risk predictor in this group of patients. <h3>Disclosure of interest</h3> None Declared.
Studies in Histochemistry. XX. Urease in the Human Stomach with Respect to Acid Secretion in Ulcer and Cancer&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: David Glick
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article Studies in Histochemistry. XX. Urease in the Human Stomach with Respect to Acid Secretion in Ulcer and Cancer Get access David Glick David Glick associate professor of physiological chemistry Department of Physiological Chemistry, University of Minnesota, Minneapolis Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 321–329, https://doi.org/10.1093/jnci/10.2.321 Published: 01 October 1949
SAT0072 Performance of Patient Reported Outcomes in the Assessment of Rheumatoid Arthritis Disease Activity: The Experience of the Espoir Cohort
Authors: H. Che, B. Combe, J. Morel, O. Meyer, A. Cantagrel, L. Gossec, C. Lukas
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Activity of rheumatoid arthritis (RA) can be assessed by several outcome measures: joint counts, inflammatory syndrom but also auto-questionnaires such as global patient assessment. The importance of Patient Reported Outcomes (PROs) has been recently put forward. <h3>Objectives</h3> To determine whether patient self-assessment can reflect RA disease activity. <h3>Methods</h3> Data from patients included in the early arthritis ESPOIR cohort and fulfilling ACR/EULAR 2010 RA criteria at month 12 were used. The following PROs (Visual Analog Scales for fatigue, pain, patient assessment of disease activity; HAQ; SF36; EMIR-court and RAPID3) and their association with disease activity assessed by DAS28-3 variables, were measured. DAS28-3 variables (including tender joint count, swollen joint count and erythrocyte sedimentation rate) was preferred to DAS28-4 variables in order to limit the input of subjective and patient-derived appreciation when defining the level of disease activity. We compared the influence of disease characteristics on each PRO by Student t tests. The association between PROs and disease activity was assessed in several ways: part of explained variance, correlation and performance of each PRO in differentiating low versus higher disease activity states. <h3>Results</h3> 677 patients (83.2%) of the 813 patients of the ESPOIR cohort, were analyzed as they respondend to the ACR/EULAR 2010 criteria of RA at month 12.Their mean age was 48.6±12.3 ans with 77.4% of female, with a mean duration of disease of 3.41±1.74 months, 60.5% were rheumatoid factor or anti-citrullinated protein positives, 16.4% had anxiodepressive disorder and 15.1% had radiological lesions according to ACR/EULAR criteria. Disease activity assessed by DAS28-3 avriables was, at inclusion, 5.0±1.2, with a decrease during the follow-up. Whatever the status of disease activity, patients with the lowest disease activity always had significantly less impaired PROs. All analyzed PROs showed moderate correlations with RA disease activity. The PRO showing the best association with DAS28-3v in determining RA disease activity states, was RAPID3 (Pearson correlation coefficient between 0.45-0.55, explained variance between 30-45%, sensitivity between 69-100% and specificity between 55-78%). PROs with the highest association with disease activity were global PROs (RAPID3, EMIR-court) followed by those assessing physical function. <h3>Conclusions</h3> Association between PROs and RA disease activity as measured by DAS28-3 variables remains moderate. RAPID3, a global PRO, showed the best association with disease activity compared to the other analyzed PROs. Evaluation of disease activity with only an auto-questionnaire seems to be difficult. <h3>Disclosure of Interest</h3> None declared
Methicillin-resistant Staphylococcus aureus nasal carriage among healthy employees of the Hellenic Air Force
Authors: S Karapsias, E T Piperaki, I Spiliopoulou, G Katsanis, A Tseleni - Kotsovili
Journal: Eurosurveillance (2008)

The prevalence of methicillin-resistant Staphylococcus aureus nasal carriage among 959 healthy employees of the Hellenic Air Force was investigated from November 2004 to October 2005. Nine participants were found to be colonised by methicillin-resistant Staphylococcus aureus (MRSA) (SCCmec type IV). Eight of the MRSA isolates were PVL-negative and belonged to ST30 by MLST, while the remaining one isolate was PVL-positive and classified as ST-80.
Serum Estrogens and Estrogen Responsiveness in 7,12-Dimethylbenz[&lt;italic&gt;a&lt;/italic&gt;]anthracene-Induced Mammary Tumors as Influenced by Dietary Fat&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: C Ip, M M Ip
Journal: JNCI Journal of the National Cancer Institute (1981)

The effect of dietary fat on mammary tumor incidence, estrogen-binding capacity as related to the hormone dependency of the tumors, and circulating estrogen levels in Sprague-Dawley rats given an oral dose of 7,12-dimethylbenz[a]anthracene (DMBA) was investigated. Rats were fed diets consisting of 0.5, 5, or 20% corn oil starting at weaning and were administered 5 mg DMBA at 50 days of age. Tumor incidences were 13, 46, and 75% for the groups given 0.5, 5, and 20% fat, respectively, when the experiment was terminated 20-22 weeks later. Serum estradiol, measured at proestrus at 50 days of age and at the end of the experiment, was slightly depressed at both time points in rats fed the 0.5% fat diet but was similar in the other 2 groups. Serum estrone levels were not significantly different at either time point. Estrogen receptor levels in the tumor were the same in the groups given 5 and 20% fat but were lower in the group given 0.5% fat. No difference was detected in the progesterone receptor concentrations. Furthermore, most (approximately 70%) of the tumors in all 3 dietary groups regressed in response to ovariectomy, which suggested that dietary fat has very little influence on the estrogen dependence of the tumor. This observation suggested that fat intake does not result in any intrinsic difference in the biochemical action of estrogen.
Tumors of the Human Nervous System in Tissue Culture. II. An Analysis of Fibroblastic Activity in Meningiomas&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: I COSTERO, C M POMERAT, R BARROSOMOGUEL, A Z CHEVEZ
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Tumors of the Human Nervous System in Tissue Culture. II. An Analysis of Fibroblastic Activity in Meningiomas Get access Isaac Costero, M.D., Isaac Costero, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles M. Pomerat, Ph.D., Charles M. Pomerat, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Rosario Barroso-Moguel, M.D., Rosario Barroso-Moguel, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Agustín Z. Chévez, M.D. Agustín Z. Chévez, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 5, April 1955, Pages 1341–1365, https://doi.org/10.1093/jnci/15.5.1341 Published: 01 April 1955 Article history Received: 09 April 1954 Published: 01 April 1955
A diet-induced animal model of non-alcoholic fatty liver disease and hepatocellular cancer
Authors: Amon Asgharpour, Sophie C. Cazanave, Tommy Pacana, Mulugeta Seneshaw, Robert Vincent, Bubu A. Banini, Divya Prasanna Kumar, Kalyani Daita, Hae-Ki Min, Faridoddin Mirshahi, Pierre Bedossa, Xiaochen Sun, Yujin Hoshida, Srinivas V. Koduru, Daniel Contaifer, Urszula Osinska Warncke, Dayanjan S. Wijesinghe, Arun J. Sanyal
Journal: Journal of Hepatology (2016)

The lack of a preclinical model of progressive non-alcoholic steatohepatitis (NASH) that recapitulates human disease is a barrier to therapeutic development.