tbuckley/cabot-search huggingface dataset:
Mesenchymal Stem Cells Skewed Their Phenotype Toward the Osteogenic Lineage Support the Hematopoietic Cell Differentiation
Authors: Hisayuki Yao, Yasuo Miura, Satoshi Yoshioka, Yoshihiro Hayashi, Akihiro Tamura, Hideyo Hirai, Taira Maekawa
Journal: Blood (2012)
Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial
Authors: Maria Buti, Edward Gane, Wai Kay Seto, Henry L Y Chan, Wan-Long Chuang, Tatjana Stepanova, Aric-Josun Hui, Young-Suk Lim, Rajiv Mehta, Harry L A Janssen, Subrat K Acharya, John F Flaherty, Benedetta Massetto, Andrea L Cathcart, Kyungpil Kim, Anuj Gaggar, G Mani Subramanian, John G McHutchison, Calvin Q Pan, Maurizia Brunetto, Namiki Izumi, Patrick Marcellin
Journal: The Lancet. Gastroenterology & hepatology (2016)
Ten Years of Preserved Kidney Function After Islet Transplant Graft Failure
Authors: Eduardo Peixoto, Francesco Vendrame, Alvaro Arnau, Nathalia Padilla, David Baidal, Ana Alvarez, Valentina Delmonte, Alessia Fornoni, Camillo Ricordi, Rodolfo Alejandro
Journal: Diabetes Care (2016)

Several studies in patients with type 1 diabetes have examined the impact of islet transplantation (ITx) on renal function (1–3). Our group and others (1,4) have reported the beneficial effect of ITx. Equally relevant, however, is the assessment of renal function in patients with graft failure (GF) who are exposed to the well-known potential toxicity from immunosuppressive drugs and risk of development or progression of diabetic nephropathy related to unstable glycemic control (5). In this study, we examined the renal function of 12 recipients of allogeneic ITx who developed GF (stimulated C-peptide <0.3 ng/mL) but had at least 1 year (range 1.0–5.1) of graft function. Maintenance immunosuppression consisted of sirolimus and tacrolimus, which were discontinued after GF. Patients were enrolled in the ongoing Long Term Surveillance of Islet Transplant Recipients Following Complete Graft Loss study at the University of Miami, 6.0 ± 1.8 years (range 2.9–8.8) after GF. In this interim report, we provide data on renal function for a mean of 10.7 years after islet GF (Fig. 1 A ). The estimated glomerular filtration rate (eGFR) at the end of follow-up was comparable to …
Molecular Classification of Mixed Hepatocellular-Cholangiocarcinoma Tumors
Authors: A. Moeini, D. Sia, Z. Zhang, G. Camprecios, A. Stueck, M. Isabel Fiel, O. Miltiadous, I.M. Quetglas, Ke Hao, A. Villanueva, S.N. Thung, M.E. Schwartz, J.M. Llovet
Journal: Journal of Hepatology (2016)
Efficacy of Interferon-Free Therapy in Cirrhotic and Non-Cirrhotic Chronic Hepatitis C Patients in Clinical Practice
Authors: E. Badia, H. Ramos, P. Linares, I. Martín, C. Almohalla, F. Jorquera, I. García, M. Vásquez, P. Conde, B. Alvarez, G. Karpman, V. Gozalo, S. Lorenzo, J. Gómez, D. Joao, M. de Benito, L. Ruiz, F. Jiménez, F. Sáez-Royuela
Journal: Journal of Hepatology (2016)
Autonomy in ants and humans
Authors: Jeremy I M Carpendale, Michael Frayn
Journal: Behavioral and Brain Sciences (2016)

Abstract Drawing lessons regarding the consequences of ultrasociality in ants and humans depends crucially on recognizing differences as well as similarities in the way that species are social. We focus on Gowdy &amp; Krall's use of the concept of autonomy to explicate essential differences in the ways in which ants and humans are social.
Hypogonadism alters cecal and fecal microbiota in male mice
Authors: Naoki Harada, Ryo Hanaoka, Kazuki Hanada, Takeshi Izawa, Hiroshi Inui, Ryoichi Yamaji
Journal: Gut Microbes (2016)

Low testosterone levels increase the risk for cardiovascular disease in men and lead to shorter life spans. Our recent study showed that androgen deprivation via castration altered fecal microbiota and exacerbated risk factors for cardiovascular disease, including obesity, impaired fasting glucose, excess hepatic triglyceride accumulation, and thigh muscle weight loss only in high-fat diet (HFD)-fed male mice. However, when mice were administered antibiotics that disrupted the gut microbiota, castration did not increase cardiovascular risks or decrease the ratio of dried feces to food intake. Here, we show that changes in cecal microbiota (e.g., an increased Firmicutes/Bacteroidetes ratio and number of Lactobacillus species) were consistent with changes in feces and that there was a decreased cecal content secondary to castration in HFD mice. Castration increased rectal body temperature and plasma adiponectin, irrespective of diet. Changes in the gut microbiome may provide novel insight into hypogonadism-induced cardiovascular diseases.
Tenofovir versus Tenofovir plus Entecavir for Chronic Hepatitis B with Lamivudine-Resistance and Entecavir-Resistance
Authors: S. Lee, S.H. Ahn, K.S. Jung, D.Y. Kim, B.K. Kim, S.U. Kim, O. Baatarkhuu, H.J. Ku, K.-H. Han, J.Y. Park
Journal: Journal of Hepatology (2016)
Receptor Tyrosine Kinases, Notch Mutations and PTEN Loss Converge On mTOR in T-ALL and Cause Addiction to Cap Dependent mRNA Translation.
Authors: Adrian Schwarzer, Helmut Holtmann, Martijn Brugman, Johann Meyer, Doris Steinemann, Brigitte Schlegelberger, Zhixiong Li, Christopher Baum
Journal: Blood (2012)
Sofosbuvir and Ledipasvir in Attainment of SVR12 in Sickle Cell Disease (SCD) Sub-Population with Chronic Hepatitis C (CHC) a Single Center Prospective Open Label Clinical Pilot Study – Slash C Trial
Authors: P.P. Basu, N.J. Shah, M.M. Aloysius, L. Kavali, E. Shehi, R.S. Brown
Journal: Journal of Hepatology (2016)
A Phase 1 Study of Denintuzumab Mafodotin (SGN-CD19A) in Adults with Relapsed or Refractory B-Lineage Acute Leukemia (B-ALL) and Highly Aggressive Lymphoma
Authors: Amir T Fathi, Uma Borate, Daniel J. DeAngelo, Maureen M. O'Brien, Tanya Trippett, Bijal D Shah, Gregory A. Hale, James M. Foran, Lewis B. Silverman, Raoul Tibes, Stuart Cramer, Melinda Pauly, Stella Kim, Ana Kostic, Xiaohui Huang, Yang Pan, Robert Chen
Journal: Blood (2015)
Assessment of the heterogeneity of sputum cytokine profiles by unsupervised cluster analysis in a large asthma cohort
Authors: Sven Seys, Hans Scheers, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter Goeminne, Paul Van den Brande, Jan Ceuppens, Lieven Dupont, Dominique Bullens
Journal: Allergy (2014)
Efficacy and Clinical Impact of Daclatasvir-Based Antiviral Therapy in Severe Recurrent Hepatitis C after Liver Transplantation. Results from a Multicenter Spanish Group
Authors: M.M.S. Plaza, C. Vinaixa, L.C. Fuste, J.M.P. Acevedo, I. Fernández, D. Rincón, G. Sánchez-Antolín, L. González-Diéguez, A. Otero, S. Lorente, M. Testillano, M. Londoño, F. Casafont, J.A.P. Miñano, E. Molina, J.C. Alonso, S. Pascual, V. Cuervas-Mons, J.I. Herrero, I. Narváez, M.G. González, V. Aguilera, J. Llaneras, A. Manrique, J.M.S. Martín, C. Almohalla, V. Cadahia, F. Suárez, T. Serrano, R. Bañares, M. Prieto
Journal: Journal of Hepatology (2016)
The cost of hospitalization secondary to severe chemotherapy induced diarrhea (CID) in patients with colorectal cancer
Authors: A. Shah, J. Maroun, G. Dranitsaris
Journal: Journal of Clinical Oncology (2004)

6111 Background: Previous studies have suggested that grade III/IV diarrhea is a common complication in colorectal cancer occurring in up to 50% of patients receiving chemotherapy (Arbuckle et al, 2000). In some of these patients, hospitalisation for supportive care is often required. However, the impact that these hospitalised patients have on overall health care resource utilization has not been quantified. In this study, a cost of illness analysis was conducted to estimate the overall cost of patients with colorectal cancer who were hospitalised for supportive care secondary to severe diarrhea. Methods: This was a retrospective cohort study consisting of patients with colorectal cancer that had received fluoropyrimidines alone or in combination with irinotecan or oxaliplatin and had developed grade III or IV diarrhea that resulted in a hospital admission for supportive care. Data collection included patient demographics, disease related information and healthcare resource utilization to manage the grade III/IV CID event. The final sample size for this cohort study was 63 patients resulting in precision that extended to $1,800. Results: Patients had a mean age of 64.2 years and 31 of 63 (49%) were receiving adjuvant chemotherapy with a curative intent. The severe CID developed after the first cycle of chemotherapy in 58% of cases and contributed to a dose reduction, change or discontinuation of chemotherapy in 34%, 15.9% and 34% of patients respectively. Overall, the median length of hospital stay was 8 days (range = 1 to 49 days) translating to a mean cost of $8,230 per patient (95%CI: $6,519 to $9,942). The CID successfully resolved in 54 of 63 patients (85.7%). There were a total of 9 deaths with 7 (11%) possibly being related to the diarrhea. Conclusions: The findings of the current study revealed that severe diarrhea requiring a hospital admission is a costly and potentially fatal complication of chemotherapy in colorectal cancer. The identification of predictive factors and the implementation of prophylactic measures could reduce the morbidity and mortality associated with CID. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Novartis Novartis Canada
Une épidémie d'intoxications diarrhéiques dues aux fruits de mer à Anvers, Belgique
Authors: K De Schrijver, I Maes, L De Man, J Michelet
Journal: Eurosurveillance (2002)

A Anvers (Belgique), 403 cas d’intoxication lies a la consommation de coquillages ont ete rapportes apres l’ingestion de moules bleues. Les symptomes incluaient la diarrhee, des vomissements, des douleurs abdominales, et la nausee. L’analyse des echantillons de selles des patients a permis d’exclure tout autre diagnostic bacterien et viral. Les tests biologiques chez la souris ont revele la presence de biotoxines specifique des dinoflagelles, mises en evidence et quantifiees par CL-SM. Les moules etaient importees du Danemark, et appartenaient a un lot presentant un taux eleve d’acide okadaique, au dela des normes autorisees.
Lecithin-Cholesterol Acyltransferase Activity and Apolipoprotein A1 Levels Predict Progression to Organ Failure in ACLF Patients and 3 Month Mortality Following Acute Cirrhosis Decompensation
Authors: S. Samra, K.L. Thomsen, A.F.B. DaSilva, R. Sawhney, H. Jones, J. Owen, R.P. Mookerjee
Journal: Journal of Hepatology (2016)
Efficacy of Glutathione for the Treatment of Non-Alcoholic Fatty Liver Disease: An Open-Label, Multicenter, Prospective Study
Authors: T. Kessoku, Y. Sumida, K. Imajo, Y. Honda, Y. Ogawa, M. Yoneda, M. Ono, Y. Egushi, A. Nakajima
Journal: Journal of Hepatology (2016)
Rapid Changes in Cholesterol in Chronic Hepatitis C Patients Treated with Antivirals and Potential Impacton Cardiovascular Risk
Authors: L.M. Benitez, I. Esposito, I. Baños, A. Duca, M.J. Citores, P. Barreiro, A. Royuela, V. Cuervas-Mons, V. Soriano, C. De Mendoza
Journal: Journal of Hepatology (2016)
Utility of Multiparameter Flow Cytometry Immunophenotypic Studies In Patients with Systemic Light Chain (AL) Amyloidosis
Authors: Bruno Paiva, María-Belén Vidriales, Jose J. Perez, Maria-Consuelo López-Berges, Ramón García-Sanz, Enrique M. Ocio, Rebeca Garcia, Alfonso Garcia de Coca, Emilia Pardal, Magdalena Sierra, Jose Hernández, Natalia de las Heras, Josefina Galende, Jose Maria Alonso, Abelardo Bárez, María-Victoria Mateos, Jesus F San Miguel
Journal: Blood (2010)
Pre-Emptive T-Rapa Cell DLI for Therapy of High-Risk Lymphoma After Low-Intensity Allogeneic HCT
Authors: David Halverson, Miriam E. Mossoba, Seth M. Steinberg, Bazetta blacklock-Schuver, Frances T. Hakim, Roger Kurlander, Juan Gea-Banacloche, Claude Sportes, Nancy M. Hardy, Dennis D. Hickstein, Steven Z. Pavletic, Hanh Khuu, Marianna Sabatino, David Stroncek, Susan F. Leitman, Scott D. Rowley, Michele L. Donato, Andre Goy, Robert Korngold, Andrew L. Pecora, Bruce L. Levine, Carl H. June, Michael R. Bishop, Carol Carini, Tatyana Feldman, Anthony R. Mato, Ronald E. Gress, Daniel H. Fowler
Journal: Blood (2012)
Assessing allergy management information needs in primary care based on requests for sIgE determinations
Authors: T. M. Brakel, B. M. J. de Flokstra-Blok, J. N. G. Elberink, M. L. A. Schuttelaar, W. A. Christoffers, E. M. Roerdink, T. van der Molen, A. E. J. Dubois
Journal: Allergy (2013)

Background: For many patients suspected of allergy, management is initially and often ultimately the responsibility of general practitioners (GPs). However, previous studies have shown that GPs find that providing such care is difficult, especially when anaphylactic symptoms occur. An area of concern is the interpretation of sIgE tests. The purpose of this study is to obtain insight in characteristics of primary care patients for whom an IgE test was requested, with a view to developing a system for providing additional information to the GP together with the test results. Method: Patients who were sent to a laboratory for one or more sIgE tests received a questionnaire which was completed at home. This questionnaire was specifically developed and tested to obtain key information about the patients' medical allergy history. Parents reported about their child's allergy. Results: From the patients (n = 118, Mage = 31.7 years; range 12 months to 81 years) 40% was male. For 55% of the patients no diagnosis had been established. A single allergy diagnosis had been made for 26.5% of the patients and 19% reported to have multiple allergies. Of the patients for whom one or more diagnoses were reported, 15.4% had asthma, 23.9% rhinitis, 18.8% eczema, 4.3% food allergy, and 6.8% had an unspecified allergy. The main reasons for requesting a sIgE test were rhinitis and asthma, 51% and 26% respectively. Less frequent referrals for IgE testing were: eczema 15%, food related allergy 9%, non-food induced anaphylaxis 1%, and other allergy disorders 18%. Conclusion: Although previous studies show that GPs feel more comfortable managing asthma and rhinitis than patients with food allergy and anaphylaxis, this is not reflected in the request for sIgE testing. A management support system for GPs should therefore include information on airway allergy as well as anaphylaxis.
Universal Access to New Generation Direct-Acting Antivirals to Reduce the Burden of Hepatitis C in Portugal
Authors: R. Tato-Marinho, H. Mota-Filipe, A.P. Martins, J. Martins, J. Rodrigues, V. Andreozzi, B. Vandewalle, J. Félix, E.C. Alves
Journal: Journal of Hepatology (2016)
Beneficial Effects of Ornithine Phenylacetate to Attenuate Muscle Mass Loss and to Prevent Hepatic Encephalopathy in Experimental Cirrhosis
Authors: C.R. Bosoi, M. Oliveira, M.-A. Clément, M. Tremblay, G.A. Ten Have, N.E. Deutz, C.F. Rose
Journal: Journal of Hepatology (2016)
The prognostic relevance of CXC-chemokines in stage II and III colorectal cancer (CRC) tissue and inflammatory infiltrate.
Authors: O. Oladipo, S. Conlon, T. O'Grady, C. Purcell, C. Wilson, P. Maxwell, M. Stevenson, E. Kay, R. H. Wilson, D. J. Waugh
Journal: Journal of Clinical Oncology (2010)

10588 Background: Studies have linked CXC chemokines with CRC progression but their role in resected CRC is unclear. We explored the prognostic impact of CXC chemokine/receptor expression by immunohistochemistry (IHC) in stage II and III CRC tissue and stroma. Methods: Tissue microarrays were constructed from stage II and III CRC biopsies (n = 254) from a phase III study comparing 5FU/folinic acid chemotherapy with observation alone after surgery. Expression of CXCL1 and CXCL8, and their receptors CXCR1 and CXCR2 in CRC cells and adjacent normal tissue was graded by IHC, using a combined score of the proportion of cells with staining and the intensity of the staining. CXCL8 expression in the inflammatory infiltrate was scored as positive or negative. Data was correlated with clinicopathological factors and survival endpoints. Results: Expression of CXCL1, CXCR1 and CXCR2 was elevated in tumour epithelium relative to patient-matched normal tissue (Wilcoxon signed ranks test; p < 0.01). CXCL1 expression correlated with that of its receptor, CXCR2, in CRC tissue (Spearman rank correlation, p < 0.01). There was no correlation between CXCL1, CXCR1 or CXCR2 and disease stage or survival endpoints across the cohort; but univariate subgroup survival analysis showed a significant association between higher CXCL1 expression and worse relapse-free survival in stage III patients (p = 0.04). CXCL8 expression was lacking in colorectal tissue, but present within the inflammatory infiltrate. Tumour infiltrate CXCL8 positivity correlated with earlier disease stage (p < 0.01) and improved relapse-free survival (median survival not reached) compared with negative staining (median survival 69 months; 95%CI: 37.7-100.3, p < 0.01 log rank test). Earlier disease stage and positive infiltrate CXCL8 expression were independent predictors for enhanced relapse-free survival in the cohort (p < 0.01) on multivariate Cox regression analysis. Conclusions: CRC epithelium is subject to continuous autocrine CXC chemokine signalling; this may have adverse prognostic effects in stage III CRC. Conversely, positive CXCL8 expression within the tumour immune infiltrate may have a good prognostic significance. No significant financial relationships to disclose.
Tm6sf2 and Ncan Wildtype Together with Several Long-Chain Phosphatidylcholines Are Linked to a Healthy Liver in Obese Subjects
Authors: A. Feldman, S.K. Eder, T.K. Felder, L. Kedenko, B. Paulweber, A. Stadlmayr, C. Datz, E. Aigner
Journal: Journal of Hepatology (2016)
Noninvasive Assessment of Liver Fibrosis and Steatosis in HIV-Monoinfected Subjects
Authors: G. Ferraioli, L. Maiocchi, R. Lissandrin, C. Tinelli, C. Filice, E. Above, G. Chieffo, S. Cima, P. Columpsi, G. Contardi, C. Dellafiore, M. Di Gregorio, R. Gulminetti, R. Maserati, S. Novati, G. Poma, P. Sacchi, D. Zanaboni
Journal: Journal of Hepatology (2016)
Early metabolic response evaluation on PET-CT after a single cycle of chemotherapy in patients with cT3-4N0/+ oesophageal or GE-junction cancer subsequently treated by neoadjuvant chemoradiotherapy.
Authors: G. Sergeant, C. Deroose, G. De Hertogh, J. Moons, W. Coosemans, P. Nafteux, E. Van Cutsem, K. Haustermans, L. Mortelmans, T. Lerut
Journal: Journal of Clinical Oncology (2010)

e14505
Ursodeoxycholic Acid Modulates the Effects of Lithocholic Acid and Bilirubin on the Gene Expression Profiling in Osteoblastic Cells
Authors: S. Ruiz-Gaspà, N. Guañabens, M. Dubreuil, P. Peris, A. Monegal, A. Pares
Journal: Journal of Hepatology (2016)
GP who supplied abortion drug in “fake sheikh” sting is struck off
Authors: Clare Dyer
Journal: BMJ (2016)

A privately practising GP who supplied misoprostol to an undercover London reporter notorious for posing as a wealthy sheikh has been struck off the UK medical register.

Majeed Ridha, 67, was consulted in London’s Cumberland Hotel in 2012 by a man who said that he wanted to give the drug to a woman who “doesn’t want to go to an abortion clinic.” Ridha arranged for a pharmacist he often worked with to give misoprostol to the man and charged him £250 (€290; $325), unaware that he was the well known but rarely photographed undercover reporter Mazher Mahmood, 53, popularly known as the “fake sheikh.”

Mahmood, who was working for the Sunday Times , sought out Ridha, who …
Triclosan-containing sutures versus ordinary sutures for reducing surgical site infections in children: a double-blind, randomised controlled trial
Authors: Marjo Renko, Niko Paalanne, Terhi Tapiainen, Matti Hinkkainen, Tytti Pokka, Sohvi Kinnula, Juha-Jaakko Sinikumpu, Matti Uhari, Willy Serlo
Journal: The Lancet Infectious Diseases (2016)
P180 5 year retrospective evaluation of indwelling pleural catheter safety in patients undergoing chemotherapy: Abstract P180 Table 1
Authors: C Chan Wah Hak, P Sivakumar, L Ahmed
Journal: Thorax (2015)

<h3>Introduction and objectives</h3> Indwelling pleural catheters (IPC) are well established in the management of malignant pleural effusions. However, there is some reluctance in its use in patients receiving chemotherapy due to a hypothetical increased risk of infection. There are no prospective trials primarily examining IPC safety in chemotherapy. Retrospective series suggest a similar IPC-related complication rate in chemotherapy and non-chemotherapy patients.<sup>1,2</sup> Our primary study objective is to determine the safety of IPC insertion in chemotherapy. <h3>Methods</h3> We conducted a retrospective analysis of all patients who underwent IPC insertion for malignant pleural effusion at our trust from September 2010 to December 2014. Data was collected on IPC insertion and removal, tumour type, systemic chemotherapy, pleural infection and other complications. <h3>Results</h3> 104 patients were identified, (Table 1) 43 in chemotherapy group and 61 in non-chemotherapy group. The incidence of pleural infection in chemotherapy group vs non-chemotherapy group, 4 (9.3%) vs 4 (6.5%) respectively, was not statistically different (Fisher’s exact <i>p = 0</i>.4). There was no significant difference in 6-month infection-free duration from the date of IPC insertion (log rank <i>p = 0</i>.6). Overall 6-month mortality in chemotherapy group was significantly lower than in non-chemotherapy group (log rank <i>p = 0</i>.007). <h3>Conclusions</h3> This is the second largest retrospective case-control series which concludes that systemic chemotherapy is safe in patients with indwelling pleural catheters. <h3>References</h3> 1 Mekhaiel E, Kashyap R, Mullon JJ, <i>et al</i>. Infections associated with tunnelled indwelling pleural catheters in patients undergoing chemotherapy. <i>J Bronchology Interv Pulmonol</i>. 2013;<b>20</b>(4):299–303 2 Morel A, Mishra E, Medley L, <i>et al.</i> Chemotherapy should not be withheld from patients with an indwelling pleural catheter for malignant pleural effusion. <i>Thorax</i> 2011;<b>66</b>(5):448–9
Mutations in idiopathic cytopenia of undetermined significance assist diagnostics and correlate to dysplastic changes
Authors: Jakob Werner Hansen, Maj Karoline Westman, Lene Dissing Sjö, Leonie Saft, Lasse Sommer Kristensen, Andreas Due Ørskov, Marianne Treppendahl, Mette Klarskov Andersen, Kirsten Grønbæk
Journal: American Journal of Hematology (2016)

Cytopenia is common in the elderly population and etiology may be difficult to assess. Here, we investigated the occurrence of mutations in patients with idiopathic cytopenia of undetermined significance and the usefulness in improving diagnostics. We included 60 patients with persistent cytopenia > 6 months without definite diagnosis of hematological neoplasm after routine assessment. Bone marrow material underwent a blinded morphology review and DNA was sequenced with a targeted 20 gene panel representing the most commonly mutated genes in myelodysplastic syndrome. Thirty seven (62%) patients carried at least one mutation at inclusion, and of these 95% carried a mutation in TET2, ASXL1, SRSF2, or DNMT3A. The most commonly mutated gene was TET2 observed in 43% of all patients. During one to eight years follow-up seven patients progressed to a myeloid neoplasm and six of these had a detectable mutation at study entry. Median time to progression was 53 months (range 10-78), and at time of progression each patient had at least two mutations detected. Mutations in TP53 and NRAS were not present in patients at inclusion, but identified as secondary hits triggering progression. The morphology review was concordant in 68% of all cases, and 93% of the cases reclassified into the group "highly suspicious for MDS" had a mutation. All patients who had a concordant review "highly suspicious for MDS" had at least two mutations detected. Overall, we show that morphology examination is challenging in this heterogeneous group and targeted sequencing helps identify patients at risk of progression. Am. J. Hematol. 91:1234-1238, 2016. © 2016 Wiley Periodicals, Inc.