tbuckley/cabot-search huggingface dataset:
246. Optical Control of Mammalian Endogenous Transcription and Epigenetic States
Journal: Molecular Therapy (2014)

The dynamic nature of gene expression enables cellular programming, homeostasis and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates approaches that enable spatially and temporally precise modulation of gene expression. Recently, a variety of microbial and plant-derived light-sensitive proteins have been engineered as optogenetic actuators, enabling high-precision spatiotemporal control of many cellular functions. However, versatile and robust technologies that enable optical modulation of transcription in the mammalian endogenous genome remain elusive. Here we describe the development of light-inducible transcriptional effectors (LITEs), an optogenetic two-hybrid system integrating the customizable TALE DNA-binding domain with the light-sensitive cryptochrome 2 protein and its interacting partner CIB1 from Arabidopsis thaliana. LITEs do not require additional exogenous chemical cofactors, are easily customized to target many endogenous genomic loci, and can be activated within minutes with reversibility. LITEs can be packaged into viral vectors and genetically targeted to probe specific cell populations. We have applied this system in primary mouse neurons, as well as in the brain of freely behaving mice in vivo to mediate reversible modulation of mammalian endogenous gene expression as well as targeted epigenetic chromatin modifications. The LITE system establishes a novel mode of optogenetic control of endogenous cellular processes and enables direct testing of the causal roles of genetic and epigenetic regulation in normal biological processes and disease states.
Cardiac arrest during ECT modified by beta-adrenergic blockade
Authors: P Decina, S Malitz, H A Sackeim, J Holzer, S Yudofsky
Journal: American Journal of Psychiatry (1984)

A hypertensive patient with a history of diabetes and ischemic heart disease was given propranolol before ECT and experienced cardiac arrest after subconvulsive electrical stimulation. The authors suggest exercising caution when combining beta-adrenergic blockade and ECT.
One hundred years ago: Reduction of dislocations immediately after the accident
Authors: Walter G. Walford
Journal: BMJ (2004)

It does not seem to be generally known with what extreme ease a dislocation may be reduced if tackled immediately after the accident, if the opportunity occurs.

Sixteen years ago I dislocated my shoulder in a fall from a tricycle and I got a gentleman to put it in for me the moment I rose from the ground. Three weeks ago I had a similar accident, from a side slip when on a bicycle, to the same arm. Once again on asking a bystander to hold me firmly by the wrist while I gave a good pull, the head of the humerus was instantly replaced.

On each occasion the reduction was quite painless and could have been effected by a fairly strong child of 10 or 12. On each occasion I had very little subsequent pain after a bandage had been applied, and I recovered the full range of movements of my arm in three weeks.
THE FUTURE OF MEDICAL EDUCATION IN THE UNITED STATES.
Authors: S M Aronson
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Greater Health Care Spending May Moderate Recession’s Negative Health Effects
Authors: Julie A. Jacob
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Treatment of Pneumonia
Authors: S. Coupland
Journal: BMJ (1891)

the sac of which a freslh loop of intestinie had passed and be- come strangulatedl.I lere there were two conditions.First, the old gradually increasing rupture, of whichi the contents lhad contracted adlhesions to the sac; and, seconidly, the sud- denly occurring second extruision, whlieli rendered imimediate operation necessary.No doubt at all but Mr.
Molecular and Cytogenetic Risk Stratification For Core-Binding Factor-Positive Adult AML With Analysis Of Post-Remission Treatment Outcomes Including Transplantation
Authors: Jae-Ho Yoon, Heeje Kim, Seung-Hwan Shin, Young-Woo Jeon, Jung-Ho Kim, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Seok-Goo Cho, Dong-Wook Kim, Jong-Wook Lee, Woo-Sung Min, Chong-Won Park
Journal: Blood (2013)
Report of the multisociety task force on GI training
Authors: Lawrence S Friedman, Lawrence J Brandt, Grace H Elta, J Gregory Fitz, Gregory J Gores, Philip O Katz, John F Kuemmerle, Darrell S Pardi, John J Vargo, Michael H Stolar
Journal: Hepatology (2009)

In summary, the task force recommends that the 4 gastroenterology/hepatology societies work with the ABIM to develop a competency-based curriculum that incorporates the Maintenance of Certification process to accommodate the need and desire for training and subsequent practice in specific areas of gastroenterology/hepatology. Given the increasing complexity of treating digestive diseases, allowing trainees the opportunity to develop enhanced ability and experience in specific disease areas or procedures will benefit patients. By developing these training pathways, training programs will need to measure the achievements of trainees in terms of specific defined competencies rather than the duration of training alone.
Impact of Tumour Site on Bevacizumab Efficacy in Metastatic Colorectal Cancer (Mcrc)
Authors: H. Wong, K. Field, A.J. Lomax, M. Tacey, J. Shapiro, J. McKendrick, A. Zimet, D. Yip, L. Nott, R. Jennens, G. Richardson, J. Tie, S. Kosmider, P. Parente, L. Lim, P. Cooray, B. Tran, J. Desai, R. Wong, P. Gibbs
Journal: Annals of Oncology (2014)
Controversies in the Management of Bleeding Esophageal Varices
Authors: John Terblanche, Andrew K. Burroughs, Kenneth E.F. Hobbs
Journal: New England Journal of Medicine (1989)

PATIENTS with portal hypertension and esophageal varices are grouped in one of two categories when long-term care is being considered: those who have had variceal bleeding, in whom the treatment is considered therapeutic and the aim is to prevent recurrent bleeding, and those with varices that have not yet bled, in whom the treatment is considered prophylactic. The aim in the latter patients is to prevent the first episode of bleeding, with its attendant high mortality.Long-Term Therapeutic Management after Variceal BleedingAlthough it is generally agreed that therapy is required to prevent further episodes of variceal bleeding, because each . . .
Muscle Biopsy Findings in Combination With Myositis-Specific Autoantibodies Aid Prediction of Outcomes in Juvenile Dermatomyositis
Authors: Claire T. Deakin, Shireena A. Yasin, Stefania Simou, Katie A. Arnold, Sarah L. Tansley, Zoe E. Betteridge, Neil J. McHugh, Hemlata Varsani, Janice L. Holton, Thomas S. Jacques, Clarissa A. Pilkington, Kiran Nistala, Lucy R. Wedderburn
Journal: Arthritis & Rheumatology (2016)

Juvenile dermatomyositis (DM) is a rare and severe autoimmune condition characterized by rash and proximal muscle weakness. While some patients respond to standard treatment, others do not. This study was carried out to investigate whether histopathologic findings and myositis-specific autoantibodies (MSAs) have prognostic significance in juvenile DM.
A psychodynamic perspective on the clinical impact of insurance review
Authors: G O Gabbard, T Takahashi, J Davidson, M Bauman-Bork, K Ensroth
Journal: American Journal of Psychiatry (1991)

The rise of managed care and concurrent utilization review has had a profound impact on the practice of inpatient psychiatry. Little has been written, however, on the clinical impact of the review process itself. The actions of insurance reviewers often result in their being incorporated into the psychopathology of individual patients and into the dynamics of families and institutional settings. The authors apply psychodynamic understanding to a series of case examples to illustrate how concurrent review may promote splitting, impede the patient's ability to separate from the hospital, and paradoxically reinforce the patient's illness. They also explore a number of typical responses of treatment staff and families to the review process. A case vignette demonstrating a sincere effort at mutual collaboration between payers and providers is also presented. This spirit of compromise is proposed as the solution that best serves patient care.
Seroprevalence of seven pathogens transmitted by the Ixodes ricinus tick in forestry workers in France
Authors: E. Rigaud, B. Jaulhac, N. Garcia-Bonnet, K.-P. Hunfeld, F. Féménia, D. Huet, C. Goulvestre, V. Vaillant, G. Deffontaines, G. Abadia-Benoist
Journal: Clinical Microbiology and Infection (2016)
Effect of Podophyllotoxin, &lt;italic&gt;Alpha&lt;/italic&gt;-Peltatin and &lt;italic&gt;Beta&lt;/italic&gt;-Peltatin on the Cytochrome Oxidase Activity of Sarcoma 37&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: V S WARAVDEKAR, A DOMINGUE, J LEITER
Journal: JNCI Journal of the National Cancer Institute (1952)

Effect of Podophyllotoxin, Alpha-Peltatin and Beta-Peltatin on the Cytochrome Oxidase Activity of Sarcoma 37 Get access V. S. Waravdekar, V. S. Waravdekar Laboratory of Chemical Pharmacology, National Cancer Institut4, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Domingue, A. Domingue Laboratory of Chemical Pharmacology, National Cancer Institut4, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Leiter J. Leiter Laboratory of Chemical Pharmacology, National Cancer Institut4, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 2, October 1952, Pages 393–407, https://doi.org/10.1093/jnci/13.2.393 Published: 01 October 1952 Article history Received: 12 May 1952 Published: 01 October 1952
Psychiatric aspects of radiotherapy
Authors: B M Forester, D S Kornfeld, J Fleiss
Journal: American Journal of Psychiatry (1978)

The authors evaluated 200 cancer patients, half of whom received betatron therapy and half linear accelerator therapy. The incidence and severity of anxiety and depression were high in both groups; as radiotherapy continued these symptoms tended to decrease in intensity among the patients treated with the linear accelerator and to increase among the betatron patients. Patients who denied knowledge of their diagnosis were initially less depressed and remained less depressed than those who knew or suspected that they had cancer.
Lung function decline in asthma patients with elevated bronchial CD8, CD4 and CD3 cells
Authors: Irene den Otter, Luuk N.A. Willems, Annemarie van Schadewijk, Simone van Wijngaarden, Kirsten Janssen, Ronald C. de Jeu, Jacob K. Sont, Peter J. Sterk, Pieter S. Hiemstra
Journal: European Respiratory Journal (2016)

Which inflammatory markers in the bronchial mucosa of asthma patients are associated with decline of lung function during 14 years of prospective follow-up? To address this question, 19 mild-to-moderate, atopic asthmatic patients underwent spirometry and bronchoscopy at baseline and after 14 years of follow-up (t=14). Baseline bronchial biopsies were analysed for reticular layer thickness, eosinophil cationic protein (EG2), mast cell tryptase (AA1), CD3, CD4 and CD8. Follow-up biopsies were stained for EG2, AA1, neutrophil elastase, CD3, CD4, CD8, CD20, granzyme B, CD68, DC-SIGN, Ki67 and mucins. Decline in forced expiratory volume in 1 s (FEV 1 ) % predicted was highest in patients with high CD8 (p=0.01, both pre- and post-bronchodilator) or high CD4 counts at baseline (p=0.04 pre-bronchodilator, p=0.03 post-bronchodilator). Patients with high CD8, CD3 or granzyme B counts at t=14 also exhibited faster decline in FEV 1 (p=0.00 CD8 pre-bronchodilator, p=0.04 CD8 post-bronchodilator, p=0.01 granzyme B pre-bronchodilator, and p&lt;0.01 CD3 pre-bronchodilator). Long-term lung function decline in asthma is associated with elevation of bronchial CD8 and CD4 at baseline, and CD8, CD3 and granzyme B at follow-up. This suggests that high-risk groups can be identified on the basis of inflammatory phenotypes.
The t(3;21) Fusion Product, AML1/Evi-1, Interacts With Smad3 and Blocks Transforming Growth Factor-β–Mediated Growth Inhibition of Myeloid Cells
Authors: Mineo Kurokawa, Kinuko Mitani, Yoichi Imai, Seishi Ogawa, Yoshio Yazaki, Hisamaru Hirai
Journal: Blood (1998)
Assessment of clinical outcomes and prognostic factors in patients (pts) with non-small cell lung carcinoma (NSCLC) and brain metastases (BM). Results from a single institution study
Authors: M. Dipasquale, O. Caffo, V. Murgia, A. Veccia, A. Bolner, S. Brugnara, A. Caldara, G. Fellin, A. Ferro, M. Frisinghelli, E. Magri, F. Maines, S. Mussari, M. Nagliati, G. Pani, T. Proto, C. Trentin, F. Valduga, V. Vanoni, L. Tomio, E. Galligioni
Journal: Annals of Oncology (2015)
Harvard relaxes COI rules for clinical researchers
Authors: Zosia Kmietowicz
Journal: BMJ (2016)

Harvard Medical School has relaxed its conflicts of interest (COI) rules for faculty members who conduct clinical research, more than doubling the amount they can receive from the companies whose products they are investigating.

Previous rules allowed faculty members to receive no more than $10 000 from each company whose technology they were studying. But under new rules issued on 12 May, faculty members can now receive up to $25 000 from a company. For some prolific researchers this may mean substantial amounts of industry funding.

Faculty members can also hold up to $50 000 worth of stock …
Brain Death
Authors: Peter McL. Black
Journal: New England Journal of Medicine (1978)

Brain Death as Extensive Brain NecrosisThe studies quoted in the first part of this review used as their basic concept of brain death a state of irreversible brain damage that preceded inevitable cardiac arrest. They therefore tried to justify the diagnosis of brain death in a given case by establishing that cardiovascular collapse would always occur within a certain period, making clinical recovery impossible. It can be appreciated that two difficulties might arise. The first is deciding what "imminent" might be in practical terms: whether days, weeks or months. The Collaborative Study used a three-month . . .
The Student's Surgery, a Multum in Parvo.
Journal: JAMA (1890)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 212: Prophylactic Anti-inflammatory Treatment Attenuates The Neuroinflammatory And Behavioral Effects Of Silent Cerebral Infarction
Authors: Christina L Nemeth, Gretchen N Neigh
Journal: Circulation Research (2014)

Silent brain infarction is a frequent complication of cardiac surgery and is associated with mood changes and cognitive disruption. Microsphere embolism (ME) rodent models recapitulate both the diffuse ischemic infarcts and the delayed subtle behavioral disturbances characteristic to silent infarction (SI). Previously, we have shown that ME leads to increased hippocampal inflammation, weakening of the blood brain barrier, and the infiltration of peripherally circulating inflammatory cells in rats. Given long-term increases in inflammatory activity following SI, the current study tests the efficacy of anti-inflammatory versus anti-depressant treatment strategies to reduce the inflammatory and behavioral sequelae of injury. Adult rats were administered either chronic meloxicam (preferential COX-2 inhibitor) or fluoxetine (SSRI) beginning five days prior to ME surgeries. After a two week recovery, animals were tested for anxiety-like behaviors in the open field paradigm and the hippocampus was examined for gene expression of inflammatory cytokines. Meloxicam treated animals showed a decrease in hippocampal gene expression of inflammatory markers (SPP1; p = 0.0272) and greater than a 3-fold change improvement in open field central tendency (p = 0.0003). No differences in inflammatory gene expression were observed in fluoxetine treated animals (SPP1; p = 0.3288); however, fluoxetine treatment resulted in a 2-fold change improvement in open field central tendency (p = 0.0138) suggesting that while both treatment strategies attenuate SI induced behavioral disruption, only meloxicam acts via inflammatory mechanisms. Given the long term negative consequences of increased central and peripheral inflammatory activity, the data suggest that anti-inflammatory therapeutic strategies may benefit patients at risk for SI as well as cardiac surgery candidates.
Abstract B43: Characterization of ovarian cancer cells as in vivo models for preclinical studies.
Authors: Lidia Hernandez, Marianne K. Kim, L Tiffany Lyle, Patricia S. Steeg, Christina M. Annunziata
Journal: Clinical Cancer Research (2016)

Abstract Women are most often diagnosed with ovarian cancer in late stages of the disease, making this malignancy the most common cause of death from gynecological cancers in the United States. Identification of factors associated with disease subtypes and clinical outcome is critical to enable pathway-targeted therapeutic advances. As with other systems, the value of cell lines for in vitro and pre-clinical work lies in choosing groups of cell lines with similar characteristics. To date, selection of cell lines has been based on criteria such as patient history, histological subtype at diagnosis, mutation patterns, signaling patterns and tumorigenicity in mice. Most available ovarian cancer cell lines were generated decades ago and variable information exists as to these parameters. In recent years, several studies have reported comprehensive data gathered for the most commonly available ovarian cancer cell lines. While these reviews have established greater consensus regarding the molecular characteristics of these cell lines, data on in vivo tumorigenicity of these cell lines is still only sporadically available, making it difficult to translate in vitro work to xenograft models. We have studied the tumorigenicity of 16 commonly used ovarian cancer cell lines introduced through three distinct anatomical locations: subcutaneous, intraperitoneal, and ovary intrabursal injection. We also characterized these cell lines according to gene expression profiles and phospho-proteomics, in order to create an integrated panel of information by which to choose cells logically for specific research questions. Here we report a comprehensive analysis of in vivo growth patterns and histopathology, linked to molecular characteristics. This will provide a valuable resource to the ovarian cancer research community, and better guiding the choice of cell lines for in vitro studies that can be translated efficiently into xenograft testing. Citation Format: Lidia Hernandez, Marianne K. Kim, L Tiffany Lyle, Patricia S. Steeg, Christina M. Annunziata. Characterization of ovarian cancer cells as in vivo models for preclinical studies. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B43.
Enzalutamide in Prostate Cancer after Chemotherapy
Authors: Alfredo Berruti, Daniele Generali, Marco Tampellini
Journal: New England Journal of Medicine (2012)

To the Editor: In the randomized trial reported by Scher et al. (Sept. 27 issue), 1 the administration of enzalutamide, an androgen-receptor–signaling inhibitor, was associated with an increased inci dence of headache, as compared with placebo, in patients with castration-resistant prostate cancer. Androgens are implicated in the pathogenesis of migraine; thus, it is important to understand whether the headache associated with enzaluta mide could be classified as migraine. Moreover, a deeper understanding of the pathophysiology of this side effect is clinically relevant, since a relationship between migraine and the presence of either hot flashes or seizures has been de scribed previously. 2,3 Migraine and epilepsy have pathophysiological characteristics in common, 3 so patients who have migraine during enzaluta mide therapy may be at increased risk for sei zures. Notably, headache was not reported as a clinically relevant symptom in patients with cas tration-resistant prostate cancer who received abirater one, 4 a drug that deeply reduces circulat ing androgen levels. Abiraterone was adminis tered in association with prednisone, and glucocor ticoids are efficacious in preventing migraine. 5 It would be interesting to know whether glucocor ticoids were used in the management of enzalu tamide-induced headache and whether they were effective.