tbuckley/cabot-search huggingface dataset:
Macrophage-Secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways
Authors: Ran Li, Jess D. Hebert, Tara A. Lee, Hao Xing, Alexandra Boussommier-Calleja, Richard O. Hynes, Douglas A. Lauffenburger, Roger D. Kamm
Journal: Cancer Research (2016)

Abstract The ability of a cancer cell to migrate through the dense extracellular matrix within and surrounding the solid tumor is a critical determinant of metastasis. Macrophages enhance invasion and metastasis in the tumor microenvironment, but the basis for their effects is not fully understood. Using a microfluidic 3D cell migration assay, we found that the presence of macrophages enhanced the speed and persistence of cancer cell migration through a 3D extracellular matrix in a matrix metalloproteinases (MMP)-dependent fashion. Mechanistic investigations revealed that macrophage-released TNFα and TGFβ1 mediated the observed behaviors by two distinct pathways. These factors synergistically enhanced migration persistence through a synergistic induction of NF-κB–dependent MMP1 expression in cancer cells. In contrast, macrophage-released TGFβ1 enhanced migration speed primarily by inducing MT1-MMP expression. Taken together, our results reveal new insights into how macrophages enhance cancer cell metastasis, and they identify TNFα and TGFβ1 dual blockade as an antimetastatic strategy in solid tumors. Cancer Res; 77(2); 279–90. ©2016 AACR.
Multigene MRD Assessment Improves AML Relapse Risk Stratification in Autologous Hematopoietic Cell Transplantation
Authors: Matthew P. Mulé, Gabriel N. Mannis, Jerald P. Radich, Brent L. Wood, Nestor R. Ramos, Catherine E. Lai, Michael Flanders, Charalambos Andreadis, Lloyd E. Damon, Aaron C. Logan, Thomas G. Martin, Christopher S. Hourigan
Journal: Blood (2015)
Different correlates but similar prognostic implications for right ventricular dysfunction in heart failure patients with reduced or preserved ejection fraction
Authors: Stefano Ghio, Marco Guazzi, Angela Beatrice Scardovi, Catherine Klersy, Francesco Clemenza, Erberto Carluccio, Pier Luigi Temporelli, Andrea Rossi, Pompilio Faggiano, Egidio Traversi, Olga Vriz, Frank Lloyd Dini
Journal: European Journal of Heart Failure (2016)
THU0032 Diagnostic Accuracy of Hand and Foot MRI for Early Rheumatoid Arthritis
Authors: W.P. Nieuwenhuis, H.W. van Steenbergen, L. Mangnus, E.C. Newsum, J.L. Bloem, T.W.J. Huizinga, S. le Cessie, M. Reijnierse, A.H.M. van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Early diagnosis and treatment of rheumatoid arthritis (RA) is advocated. However, in part of the RA-patients a classifiable diagnosis cannot be made at first presentation; these patients present with unclassified arthritis (UA). The use of MRI for early diagnosis of RA is recommended, yet the evidence is limited. <h3>Objectives</h3> To assess the performance of hand and foot MRI for early diagnosis of RA. <h3>Methods</h3> Unilateral contrast-enhanced 1.5T MRI of the hand and foot was performed in 589 early arthritis patients included in the Leiden Early Arthritis Clinic, of whom 229 presented with RA, 159 with other arthritides and 201 with UA. MRI-findings observed in symptom-free controls served as reference to define an abnormal MRI. In preliminary investigations, patients that presented with RA were compared with symptom-free controls and with patients that presented with other arthritides. Thereafter, the accuracy of MRI was determined in UA-patients that were followed for 1-year on fulfilling the 1987-RA-criteria (primary outcome); the secondary outcome was start of disease-modifying drugs. <h3>Results</h3> The results of the preliminary investigations were promising and showed that MRI-detected tenosynovitis was more discriminative than other types of MRI-inflammation. Of all UA-patients, 29 (14%) developed RA and 75 (37%) started disease-modifying treatment. MRI-detected tenosynovitis was associated with RA-development independent of other types of MRI-inflammation (odds ratio (OR) 7.5 95%CI 2.4–23) and also independent of age and commonly used measures of inflammation (number of swollen joints and C-reactive protein) (OR 4.2 95%CI 1.4–12.9). Within UA-patients, the negative predictive value (NPV) of abnormal tenosynovitis was 95% and the positive predictive value (PPV) 25%. The performance was best in the subgroup UA-patients presenting with oligo-arthritis (18% developed RA): PPV was 36%, NPV 98%, sensitivity 93%, and specificity 63%. Decision curve analysis revealed a higher net benefit for a model including MRI-detected tenosynovitis. <h3>Conclusions</h3> MRI-detected inflammation, MRI-detected tenosynovitis in particular, contributes to identification of the UA-patient that will develop RA. <h3>Disclosure of Interest</h3> None declared
SAT0472 Is Electrotherapy Effective in The Management of Pain, Range of Motion, Quality of Life, Edema Following Total Knee Arthroplasty Surgery? Randomized Controlled Trial
Authors: M.R. Kadi, S. Hepguler, E. Dede, C. Ozturk, S. Aydogdu, K. Aktuglu, N. Ozkayin, F.C. Atamaz
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Knee osteoarthritis is a current problem that causes limitations in patients9 activities of Daily living (1). There are many therapeutic options. Total knee arthroplasty is one of these treatment methods.Postoperative pain is one of the most commonly seen problems after this operation.The target of postoperative pain management is pain alleviation with minimum morbidity that is caused by analgesic modalities (2). Interferential current (IFC) therapy is a physical modality whose effects on postoperative pain, range of motion, edema and analgesic use has previously been shown (3). <h3>Objectives</h3> In this double-blind randomized controlled study, we aimed to investigate the effectiveness of interferential current (IFC) following total knee arthroplasty (TKA) surgery <h3>Methods</h3> 98 patients who had TKA surgery were included into the study. Patients were randomized into two groups: Group 1: IFC (n=49) and group 2: sham IFC group (n=49). After all patients received the same rehabilitation programme and cold pack, the patients in group 1 administered IFC 30 minutes 2 times a day for 5 days. Same treatment instructions were given in sham group blindly. Patients were assessed at days 0, 5 and 30th after surgery with following parameters: VAS pain (cm), edema (cm), range of motion (ROM), Short Form 36 (SF 36) and paracetamol intake (gr) <h3>Results</h3> All patients had significant improvements in all evaluation parameters (p&lt;0,05) except the subscales of the physical role and mental health in the SF 36. In comparison of the groups, paracetamol intake was significantly lower in the IFC group at 5th day (p&lt;0.05). There was no difference between groups for other evaluation parameters in all visits. <h3>Conclusions</h3> Although all patients showed significant improvement in all parameters during the study, paracetamol intake was significantly lower in the IFC group. This finding supports that IFC can decrease pain -even postoperative pain-. However, it is still uncertain which frequency is most suitable, how many times and how much minutes we need to use IFC in these patients in order to improve pain significantly. <h3>References</h3> Guyton J. Arthroplasty of ankle and knee. In: Canale S, editor. Campbell9s operative orthopaedics. St. Louis: Mosby; 1998.p.232–95. Hedenstierna G, Lofstrom J. Effect of anaesthesia on respiratory function after major lower extremity surgery. A comparison between bupivacaine spinal analgesia with low-dose morphine and general anaesthesia. Acta Anaesthesiol Scand 1985;29: 55–60. Jarit GJ, Mohr KJ, Waller R, Glousman RE. The effects of home interferential therapy on postoperative pain, edema, and range of motion of the knee. Clin J Sport Med 2003;13: 16–20. <h3>Disclosure of Interest</h3> None declared
IMiD® Immunomodulatory Drugs Lenalidomide and Pomalidomide Inhibit the Maturation of Megakaryocytes by Suppressing the Expression of GATA1
Authors: Ailing Liu, Vera Donnenberg, Shirong Li, Susanne M. Gollin, Huihui Ma, Caisheng Lu, Meihua Jin, Donna B Stolz, Markus Y. Mapara, Sara A. Monaghan, Suzanne Lentzsch
Journal: Blood (2011)
Successful In Utero Hematopoietic Stem Cell Transplantation (IUHSCT) Likely Depends on Niche Maturity, Recipient/Donor MHC Compatibility and Donor Cell Origin
Authors: Christine Jeanblanc, Evan J Colletti, Christopher D Porada, Graca Almeida-Porada, Esmail Zanjani
Journal: Blood (2010)
MUC1 Inhibition Overcomes Chemotherapy Resistance in Acute Myeloid Leukemia
Authors: Myrna Rita Nahas, Dina Stroopinsky, Hasan Rajabi, Ashujit Tagde, Athalia Rachel Pyzer, Salvia Jain, Maxwell Douglas Coll, Michal Bar-Natan, Rebecca Karp, Katarina Luptakova, Kristen Anna Palmer, Poorvi Somaiya, Jon Arnason, Malgorzata McMasters, Robin Joyce, James D. Levine, Donald Kufe, David Avigan, Jacalyn Rosenblatt
Journal: Blood (2015)
Bronchial-Associated Lymphoid Tissue (BALT) Lymphoma: A Multicenter Retrospective Analysis.
Authors: Daniele Laszlo, Sara Steffanoni, Giovanna Andreola, Rosaria Balzano, Giancarlo Pruneri, Lorenzo Spaggiari, Cristiano Crosta, Emanuele Zucca, Giovanni Martinelli
Journal: Blood (2004)
AB0581 Infliximab Therapy in Patients with Refractory Uveitis of Behçet's Disease: A Meta-Analysis
Authors: Y. Qin, X. Zhang, P. Geng, R. Luo, G. Zhang
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Behçet9s disease is a chronic inflammatory vasculitis that can affect multiple systems. Ocular involvement is common and often cause significant morbidity, such as loss of sight, and offering challenge to management due to relapse. Off-label use of anti-tumor necrosis factor (TNF) agents for Behçet9s disease (BD) is increasing. Especially for refractory uveitis <h3>Objectives</h3> To assess the effect of infliximab on refractory uveitis caused by Behçet9s disease, we conducted a meta-analysis. <h3>Methods</h3> A comprehensive search of multiple databases was performed. Weighted Mean Difference (WMD) or standardized mean difference (SMD) and 95% confidence intervals (95%CI) were calculated to assess the efficacy. Q test was used to examine the inter-study heterogeneity, and the robustness of the results was tested through sensitivity analysis. Begg9s funnel plot and Egger9s test were operated to check the publication bias. <h3>Results</h3> A total of 9 articles were included in this meta-analysis. We observed that infliximab treatment significantly reduced uveitis attack in Behçet9s disease patients (WMD=2.35, 95% CI: 1.74–2.96), which was confirmed by subgroup analysis on 6- and 12- month after treatment (WMD=2.51, 95% CI: 1.81–3.21; WMD=2.11, 95% CI: 0.62–3.60). Visual acuity was greatly improved by infliximab therapy (SMD=-0.31, 95% CI: -0.59 to -0.03). Moreover, infliximab therapy also decreased the macular thickness of Behçet9s disease patients (SMD=1.75, 95% CI: 1.35–2.15). <h3>Conclusions</h3> Infliximab therapy is effective in the treatment of Behçet9s disease patients with refractory uveitis. <h3>Disclosure of Interest</h3> Y. Qin Employee of: Yuxing Qin is employee of XIAN Janssen. The Janssen pharmaceutical companies did not provide any financial support for this work. The authors report no other conflicts of interest., X. zhang: None declared, P. Geng: None declared, R. luo: None declared, G. zhang: None declared
Polymerase Chain Reaction in the Diagnosis of Invasive Aspergillosis in Hematopoietic Stem Cell Transplant Recipients: A Meta-Analysis of Diagnostic Performance
Authors: Theodora Anagnostou, Marios Arvanitis, Panayiotis D. Ziakas, Ioannis Zacharioudakis, Fainareti Zervou, Angela Caliendo, Eleftherios E Mylonakis
Journal: Blood (2014)
FluBup-ATG-TBI for High-Risk or Advanced Adult ALL in Remission: A Retrospective Review of a Mature Cohort.
Authors: Andrew Daly, Douglas A. Stewart, Ahsan Chaudhry, Nizar J Bahlis, Christopher Brown, Peter Duggan, Michelle Geddes, Mary Lynn Savoie, Jan Storek, Maggie Yang, James A. Russell
Journal: Blood (2009)
SP0197 EULAR Educational Offer: Where Are We Now?
Authors: E. Hachulla
Journal: Annals of the Rheumatic Diseases (2016)

Education is one of the major commitments of EULAR. Over time EULAR has developed a broad educational program which today includes courses, both physical and online, rheumatology textbooks, DVDs demonstrating diagnostic and treatment practices, as well as workshops and young rheumatologist sessions scheduled at the annual EULAR congress. In addition, EULAR provides various forms of education and training grants to individuals. Listed below is an overview of the current offers: <h3>EULAR Live Courses</h3> EULAR ultrasound course EULAR ultrasound trainer course EULAR epidemiology course EULAR postgraduate course EULAR capillaroscopy course <h3>EULAR Scientific Endorsement</h3> Course on systemic lupus erythematosus European workshop for rheumatology research (ewrr) <h3>EULAR On-Line Courses</h3> EULAR on-line course on rheumatic diseases EULAR on-line course on connective tissue diseases EULAR on-line course on systemic sclerosis EULAR on-line introductory ultrasound course EULAR on-line course in paediatric rheumatology EULAR on-line course for health professionals Except for the rheumatic diseases on-line course, which lasted 2 years (with 42 Modules), all other courses correspond to a one-year training course (with 7 to 10 Modules each). Each module consists of: –a main review text including learning objectives, pictures, summary points and key references –at least two in-depth discussions expanding on clinical problems –two interactive clinical cases with questions and answers –assessment questions at the end of each module <h3>The EULAR Bookshelf</h3> EULAR textbook on rheumatic diseases EULAR textbook on systemic sclerosis Coming soon: EULAR textbook on paediatric rheumatology Musculoskeletal ultrasound in rheumatology Atlas of capillaroscopy in rheumatic diseases EULAR training DVDS: Principles of the musculoskeletal history and examination and a second one dedicated to the GALS examination (G = gait, A = arms, L = legs, S = spine) <h3>EULAR Educational Grants</h3> Training bursaries for young rheumatologists Educational visits for health professionals in rheumatology <h3>EULAR Fellow Sessions During the Annual Congress</h3> <h3>EULAR Awards presented at the Annual Congress</h3> <h3>EMEUNET</h3> the Emerging EUlar NETwork, is a EULAR working group of young clinicians and researchers in rheumatology promoting education and research Further information: http://www.eular.org/edu_publications.cfm <h3>Disclosure of Interest</h3> None declared
Efficacy and safety of wet wrap therapy for patients with atopic dermatitis: a systematic review and meta‐analysis
Authors: G. González‐López, R.M. Ceballos‐Rodríguez, J.J. González‐López, M. Feito Rodríguez, P. Herranz‐Pinto
Journal: British Journal of Dermatology (2016)

Wet wrap therapy (WWT) consists of topical steroids administered under a layer of wet cotton bandages or garments. Several trials with WWT have reported promising results in atopic dermatitis (AD). However, no systematic review and meta‐analysis on its efficacy and safety has been published. Our objective was to conduct a systematic review of the literature on WWT in AD to assess its efficacy and safety. We included randomized controlled trials among patients of all ages with a diagnosis of AD based on predefined criteria or made by a dermatologist. Electronic searches were performed from 1970 to 30 March 2016 in the Cochrane Central Register of Controlled Trials, MEDLINE, Embase and the World Health Organization International Clinical Trials Registry. Selection of studies and data extraction were performed independently by two researchers, and discrepancies were resolved by consensus. Six trials comparing WWT with topical steroids in children or adults with AD were included. Sample sizes ranged from 19 to 51 patients. Results on clinical severity and quality of life were reported incompletely and proved heterogeneous across studies. A nonsignificant tendency to increased risk of mild skin infections was observed in those treated with WWT (pooled relative risk 6·35, 95% confidence interval 0·83–48·55). The overall grade of quality of evidence for the efficacy and safety outcomes was low. In conclusion, the evidence that WWT is more effective than conventional treatment with topical steroids in AD is of low quality. Further clinical trials should establish the efficacy of WWT in AD.
Prognostic Value of Circulating Myeloblasts in Patients with Myelodysplastic Syndromes (MDS): A Proposal for Incorporation in the Revised International Prognostic Scoring System (R-IPSS)
Authors: Rami S Komrokji, Eric Padron, Najla H Al Ali, Jeffrey E Lancet, Jeff Hall, Brian Kwok, Ling Zhang, Pearlie K Epling-Burnette, Alan F List
Journal: Blood (2014)
P1338 : An international observational study to assess the use of sorafenib after transarterial chemoembolization (TACE) in patients with hepatocellular carcinoma (HCC): optimis
Authors: M. Peck-Radosavljevic, J.-L. Raoul, H.C. Lee, M. Kudo, K. Nakajima, A.-L. Cheng
Journal: Journal of Hepatology (2015)
PTH-240 Outcomes for patients at risk of malnutrition receiving a domiciliary community dietetic service: Abstract PTH-240 Table 1
Authors: S Kennelly, S Browne, G Flanagan-Rughaboor, D Loane, C Glennon
Journal: Gut (2015)

<h3>Introduction</h3> The Community Dietetic Service (CNDS) in the Midlands (ROI) provides a domiciliary service for homebound patients at risk of malnutrition. Education about the Malnutrition Universal Screening Tool (MUST)<sup>1</sup>is provided for all community nurses, as well as a number of General Practitioners (GPs) and Practice Nurses. <h3>Aim</h3> To measure outcomes for patients up to one year post referral to the CNDS. <h3>Method</h3> This study involved a retrospective review of CNDS record cards. All patients (n = 82) referred to CNDS requiring a domiciliary visit within the period (April–October 2011) were included. Outcome data from the initial dietetic intervention and up to 4 dietetic reviews in a 12 month follow-up period were included. Types of dietetic interventions used have been described elsewhere.<sup>2</sup> <h3>Results</h3> At the initial dietitian assessment patients’ mean weight and body mass index (BMI) kg m<sup>-</sup>² were 55.5kg (±14.7kg) (n = 65) and 21.3 kg m<sup>-</sup>² (±4.9 kg m<sup>-</sup>²) (n = 62) respectively. Mean age of patients was 77.3 years (±13.2) (62% female, 38% male). Most common primary diagnoses were respiratory disease (17%), cancer (16%), and dementia (12%). Twelve months post referral, 21% of patients (17/82) were deceased and 33% (27/82) remained under care of CNDS and 46% (38/82) were discharged. Reasons for discharge included patient no longer at nutritional risk (n = 33), or patient declined follow up (n = 5). <h3>Conclusion</h3> Half of patients were successfully discharged from the CNDS at 12 months. The results demonstrate that the community dietetic intervention had the greatest impact in the first 3 months, with significant improvements in weight and BMI kg m<sup>-</sup>². <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Malnutrition Advisory Group (2003) The ‘MUST’ Report. ed. MMM. Elia. Redditch: British Association for Enteral and Parenteral Nutrition Browne, S. Kennelly, S, Flanagan-Rughaboor, G and Glennon-Slattery, C (2012) Investigation of dietetic intervention and outcomes for patients at risk of malnutrition in the community<i>. Proc Nut Soc</i>.71 (OCE2)
SAT0327 B Cell-Bound Complement Activation Products in The Diagnosis and Monitoring of Systemic Lupus Erythematosus
Authors: J. Beckmann, N. Bartholomä, N. Venhoff, P. Henneke, A. Janda, U. Salzer
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by diverse pathogenic autoantibodies and clinical phenotype. Laboratory monitoring of complement activation products (CAP; C3a, C5a, C3d, C4d) is commonly used in diagnosis and follow up. CAP bound to cellular surfaces (CB-CAP) analysed by flow cytometry offer a relatively novel approach to study complement turnover in SLE. <h3>Objectives</h3> We evaluated the significance and usability of cell bound CAP in monitoring complement turnover in a whole blood staining approach, comparing cell bound CAPs on different leucocyte subpopulations with conventional complement and disease activity parameters. <h3>Methods</h3> CAP bound to lymphocyte subpopulations were analysed by flow cytometry, compared to serological complement and other SLE activity parameters determined by nephelometry, rocket electrophoresis and ELISA. <h3>Results</h3> We have analysed CB-CAPs bound to lymphocytes in 50 adult patients with SLE. B-cells and CD4+ T-cells of SLE patients showed significantly higher levels of cell-surface-bound C4d compared to controls. C4d bound to B-lymphocytes was inversely correlated with serum levels of C4 (r = -0.309, p=0.013) and C3 (r= - 0.356, p=0.004) reflecting complement decay. In addition, B-cell C4d showed a significant positive correlation with anti-dsDNA antibody levels (r =0.574, p&lt;0.001) and plasma C3d (r =0.319, p=0.009) thereby corresponding to disease activity. CB-CAPs were stable over 24 hours after blood drawing thus offering more flexibility in sample handling than conventional complement turnover assays. <h3>Conclusions</h3> Our data show that CB-CAP measurement correlates with established disease activity markers, and given its easier handling, is of possible utility in routine diagnostic and monitoring of patients with SLE. A multicentre study for evaluation of this method in a cohort of paediatric patients is planned. <h3>Disclosure of Interest</h3> None declared
The Effect of Inhibitory Antibodies on Acute Treatment of Bleeding Episodes with OΒΙ-1, an Antihemophilic Factor VIII (recombinant), Porcine Sequence, in Patients with Acquired Hemophilia Α
Authors: Heinrich D. Farin, Aaron Novack, Min Mo, Christelle Bourgeois, Frank M Horling, Bruce M. Ewenstein
Journal: Blood (2014)
Progression of Avascular Necrosis of the Hip in Sickle Cell Disease: 2 Year Follow-Up of Randomized Trial of Aggressive Physical Therapy and Hip Coring Decompression.
Authors: Elliott P. Vichinsky, Lynne Neumayr, Ann Earles, Christine Aguilar, Shanda Robertson, Eugene Orringer, Zakia Al-Lamki, James Casella, Winfred Wang, Gloria Ramirez, Charles Daeschner, Nancy Olivieri, Kenneth McClain, Mauro Grossi, Charles Pegelow, Stuart Toledano, Bea Files, Lakshmanan Krisnamurti, Abdullah Kutlar, Miguel Abboud
Journal: Blood (2004)
A Hypomorphic Cbfb Allele Reveals a Critical Dosage-Sensitive Function of Core Binding Factors at the Earliest Stages of T Cell Development.
Authors: Ivan Maillard, Laleh Talebian, Zhe Li, Yalin Guo, Daisuke Sugiyama, Maren E. Speck, Warren S. Pear, Nancy A. Speck
Journal: Blood (2005)
Biology of Childhood Acute Hybrid Leukemias in a Population-Based Study (Czech Pediatric Hematology Working Group).
Authors: Ester Mejstrikova, Jana Volejnikova, Eva Fronkova, Tomas Kalina, Katerina Zdrahalova, Andrea Polouckova, Elena Vodickova, Zuzana Zemanova, Leona Reznickova, Martina Vaskova, Martin Kovac, Jan Zuna, Jan Trka, Jan Stary, Ondrej Hrusak
Journal: Blood (2007)