tbuckley/cabot-search huggingface dataset:
Family therapy training for psychiatric residents
Authors: H T Harbin
Journal: American Journal of Psychiatry (1980)

The author describes a comprehensive four-year educational program for training psychiatric residents in marital and family therapy. Residents receive an average of 70 hours of didactic instruction and 175 hours of one-on-one supervision in family therapy; they conduct approximately 500 hours of family and marital therapy with 75--85 outpatient and inpatient families. The author identifies faculty and resident resistance to an additional theoretical model and the major involvement of nonphysician faculty but stresses that residents now have the opportunity to truly understand and implement a biopsychosocial model and that psychiatrists must increase their experience in specialized therapeutic modalities to remain clinical leaders.
Observations, With the Aid of the Electron Microscope, on the Mitochondrial Structure of Experimental Liver Tumors in the Rat
Authors: J. C. H. de MAN, M.D.
Journal: JNCI Journal of the National Cancer Institute (1960)

The size and structure of mitochondria in electron micrographs of liver cells and cells of experimentally induced liver tumors were studied in albino rats. In addition to structural differences from normal mitochondria, the mitochondria in tumor cells also were smaller in diameter. About the same small average mitochondrial diameter was found in liver cells of rats that were kept on a rice diet. Therefore it seemed possible that the small diameter of tumor mitochondria was exclusively an effect of a protein-deficient rice diet, since animals in which tumor growth was induced were kept on a rice diet plus N,N-dimethyl-p-phenylazoaniline. However, measurements of mitochondria in serial biopsies of liver tissue of an animal under different nutritional conditions indicate that the effect of the rice diet is reversible. This reversibility was not seen in tumor tissue, nor, in general, in liver tissue surrounding the tumor. In one of the animals that had received a carcinogenic diet no liver tumor developed during the 6-month period after this diet was discontinued. In the liver of this animal the mitochondria were nearly normal in diameter. These experiments indicated that tumor cells differed from normal liver cells with respect to their mitochondria, the size of which did not show the normal dependence on nutrition.
The Challenge Of HSCs Procurement For Gene Therapy: Exploring Plerixafor As Mobilization Agent
Authors: Maria Rosa Lidonnici, Annamaria Aprile, Marta Claudia Frittoli, Giacomo Mandelli, Bernhard Gentner, Laura Bellio, Elena Cassinerio, Laura Zanaboni, Maria Domenica Cappellini, Silvano Rossini, Fabio Ciceri, Sarah Marktel, Giuliana Ferrari
Journal: Blood (2013)
THE EXTIRPATION OF CULEX AT ISMAILIA
Authors: R. Ross
Journal: BMJ (1903)

I BEG to enclose for publication the translation of a report received from the general secretary of the Suez Canal Company regarding the effects of the anti-malaria campaign at Ismailia since the visit of Sir William MacGregor and myself last September. While it is obviously too early to speak definitely regarding the result on the malaria rate, the secretary is able to announce that mosquitoes of the genus Culex “ont ete supprimes d'une manniere presque absolue.” Under the term Culex, I think he means to include also gnats of the genus Stegomyia.
The EUVAC-NET survey: national measles surveillance systems in the EU, Switzerland, Norway, and Iceland
Authors: S Glismann, T Ronne, J- E Schmidt
Journal: Eurosurveillance (2001)

The EUVAC-NET network undertook a questionnaire study on measles surveillance systems in EU member countries, Switzerland, Norway and Iceland. All questionnaires were completed. Surveillance systems for measles are implemented in 16 of the 18 countries. Most countries have some case based data and in all countries the shift is towards case based surveillance for measles, though there are differences between countries concerning case definitions and classifications. A two-dose MMR vaccination schedule is implemented in all the EUVAC-NET countries but methods used for estimation of vaccination coverage are diverse.
Familial, obstetric, and other clinical correlates of minor physical anomalies in schizophrenia
Authors: E O'Callaghan, C Larkin, A Kinsella, J L Waddington
Journal: American Journal of Psychiatry (1991)

This study investigated possible antecedents of minor physical anomalies in schizophrenia, particularly in terms of obstetric and genetic factors, and demographic, clinical and cognitive correlates of such anomalies in schizophrenia.Forty-one outpatients satisfying the DSM-III criteria for schizophrenia were examined for minor physical anomalies by using the Waldrop scale. These subjects were drawn from a group of 45 such patients whose cognitive function had been previously evaluated with Trail Making Tests A and B and whose biological mothers had been interviewed for any history of obstetric complications or family history of schizophrenia.Linear multiple regression analysis showed that higher scores for minor physical anomalies were associated with impaired cognitive flexibility on Trail Making Test B, family history of schizophrenia in a first-degree relative, maternal history of obstetric complications, smaller number of siblings, later position in the birth order, and male sex. A family history of schizophrenia was particularly associated with abnormalities of the mouth. The association between minor physical anomalies in the patients and obstetric complications in their mothers appeared to be confined to instances in which the mother had a history of bleeding in early pregnancy.Minor physical anomalies indicate early dysmorphogenesis in schizophrenia, particularly in males, which appears to be associated more reliably with genetic rather than obstetric factors and with cognitive impairment.
Facing forward after Ebola: questions for the next director general of the World Health Organization
Authors: Devi Sridhar, Ilona Kickbusch, Suerie Moon, Victor Dzau, David Heymann, Ashish K Jha, Jorge Saavendra, Barbara Stocking, Liana Woskie, Peter Piot
Journal: BMJ (2016)

In light of heavy criticism of the WHO’s handling of the Ebola outbreak, the election process for the next director general will be under intense scrutiny. <b>Devi Sridhar and colleagues</b> outline the key questions on epidemic preparedness for prospective candidates
Incompetence to refuse treatment: a necessary condition for civil commitment
Authors: B Lebegue, L D Clark
Journal: American Journal of Psychiatry (1981)

The recent U.S. District Court decision in A.E. and R.R. v. Mitchell held that psychiatric patients who are civilly committed under the Utah statute have no constitutional right to refuse treatment for the mental illness that led to their commitment. This unique law incorporates a judicial determination of competency to refuse treatment at the time of the commitment hearing and thus circumvents the objection to involuntary treatment raised in Rogers v. Okin. A number of psychiatrists have urged the use of this determination of competency, and recently the U.S. Court of Appeals for the First Circuit held it to be the sine qua non for the state's use of parens patriae power in compelling committed patients to accept neuroleptic medication.
Evidence that decreased function of lymphocyte beta adrenoreceptors reflects regulatory and adaptive processes in panic disorder with agoraphobia
Authors: R J Maddock, C S Carter, J R Magliozzi, D W Gietzen
Journal: American Journal of Psychiatry (1993)

This study was designed to clarify the nature of the reduced function of the peripheral beta adrenoceptor system observed in panic disorder with agoraphobia. The authors hypothesized that this phenomenon reflected a regulatory and adaptive process.Lymphocyte beta adrenoreceptor density and affinity, basal lymphocyte cAMP level, and isoproterenol-stimulated cAMP generation were measured in 27 untreated outpatients with panic disorder with agoraphobia and 24 healthy comparison subjects. Lymphocyte beta receptor attributes were again assessed in patients after 4 weeks of double-blind treatment with adinazolam (slow-release form) or placebo. Panic frequency, agoraphobic symptoms, overall anxiety, and improvement with treatment were assessed with standard rating instruments.Multivariate statistics revealed significantly lower beta receptor density and isoproterenol-stimulated cAMP generation in patients than in comparison subjects. beta receptor density tended to normalize after adinazolam but not after placebo. Pretreatment beta receptor density was lower in treatment responders than nonresponders. Patients with mild agoraphobia had lower cAMP responsivity than patients with moderate or severe agoraphobia.Decreased function of lymphocyte beta receptors in panic disorder with agoraphobia is expressed as both decreased density and decreased cAMP responsivity. This pattern of changes, and the tendency for receptor density to normalize with treatment, is consistent with an active, regulatory process rather than a structural deficit in the beta receptor system. Preliminary clinical findings suggest that these changes may reflect adaptive processes associated with a favorable clinical course in panic disorder with agoraphobia.
Randomized phase II study of gemcitabine-oxaliplatin or gemcitabine-cisplatin in chemonaive patients with advanced non-small cell lung cancer (NSCLC)-CLEO 05
Authors: T. Le Chevalier, S. Thezenas, J. Breton, J. Pujol, B. Coudert, X. Sun, M. Laza, E. Quoix, R. Schott, J. Geneve
Journal: Journal of Clinical Oncology (2006)

7097 Background: Gemcitabine-cisplatin is one of the reference doublets used in NSCLC. Oxaliplatin is a platin analog which offers a promising efficacy/tolerance profile in NSCLC. The combination of gemcitabine and oxaliplatin has been proven feasible and active in solid tumors. Methods: Patients with chemonaive, measurable, PS 0 or 1, stage IIIB/ IV NSCLC were randomized to receive either gemcitabine 1,250 mg/m 2 day 1 &amp; 8 plus oxaliplatin 130 mg/m 2 day 1 (GEMOX) or gemcitabine 1,250 mg/m 2 day 1 &amp; 8 plus cisplatin 80 mg/m 2 day 1 (GEMCIS). Cycles were given every 3 weeks. The primary endpoint of the study was the response rate according to the RECIST criteria. Secondary endpoints included tolerance, survival and quality of life. Results: Between October 2003 and December 2004, 130 patients (66 in GEMOX and 64 in GEMCIS) were accrued at 12 centres. Baseline patient characteristics were similar in the 2 groups. Mean age was 61. There were 96 males and 34 females; 27% of patients were PS 0 and 73% were PS 1; 15% had stage IIIB and 85% had stage IV. Median number of cycles was 5 in each group. Objective response rates were 36% in GEMOX (CI 95%: 25%-50%) and 39% in GEMCIS (CI 95%: 28%-54%) respectively. Time to progression was 173 days in the GEMOX group and 163 days in the GEMCIS group. Median survival was 10.8 months in the GEMOX group and 10.4 months in the GEMCIS group. Grade III/IV neutropenia was observed in 38% of patients after GEMOX and 41% after GEMCIS; thrombocytopenia was observed in 40% and 33% of cases respectively. Grade 2+ neurotoxicity was more frequent after GEMOX (18% vs 3%). Conclusions: GEMOX has an activity comparable to GEMCIS and may be an alternative for those patients with advanced NSCLC who have a contra-indication to cisplatin. [Table: see text]
CALGB 100801 (Alliance): A Phase II Multi-Center NCI Cooperative Group Study of the Addition of Azacitidine (AZA) to Reduced-Intensity Conditioning (RIC) Allogeneic Transplantation for High Risk Myelodysplasia (MDS) and Older Patients with Acute Myeloid Leukemia (AML): Results of a “test dose” Strategy to Target Busulfan Exposure
Authors: Ravi Vij, Vera Hars, William Blum, Tsiporah B. Shore, Aaron P. Rapoport, Thomas C. Shea, Eva Hoke, Richard M. Stone, Paula Friedman, Kouros Owzar, Steven M. Devine
Journal: Blood (2014)
Deep and Durable Responses Following Venetoclax (ABT-199 / GDC-0199) Combined with Rituximab in Patients with Relapsed/Refractory Chronic Lymphocytic Leukemia: Results from a Phase 1b Study
Authors: Shuo Ma, Danielle M. Brander, John F. Seymour, Thomas J. Kipps, Jacqueline C. Barrientos, Matthew S. Davids, Mary Ann Anderson, Michael Y. Choi, Constantine S. Tam, Tanita Mason-Bright, Betty Prine, Wijith Munasinghe, Ming Zhu, Su Young Kim, Rod A. Humerickhouse, Andrew W. Roberts
Journal: Blood (2015)
Charging overseas visitors to use NHS will benefit no one, doctors’ leaders warn
Authors: Adrian O’Dowd
Journal: BMJ (2016)

GPs and primary care staff will be left with the “grunt work” of explaining to overseas visitors that they must pay for appointments under new government plans that may help no one, doctors’ leaders have claimed.

The government announced in the Queen’s speech, delivered on 18 May, that it plans to introduce an NHS Overseas Visitors Charging Bill. In her speech, which is written by the government, the Queen said, “Legislation will be introduced to ensure that overseas visitors pay for the health treatment they receive at …
Refractory Anemia With Excess Blasts In Transformation (Acute Myeloid Leukemia with 20-29% Blasts) in Older Adults is Less Aggressive Than Acute Myeloid Leukemia With ≥30% Blasts
Authors: Federico Campigotto, Veronica Klepeis, Bin Fu, Sa A. Wang, Michael J Cascio, Heesun J. Rogers, Eric D. Hsi, Craig Soderquist, Adam Bagg, Jiong Yang, Rachel C Ochs, Attilio Orazi, Kathryn Foucar, Frank Moore, Amer Mahmoud, Tracy I. George, Daniel J DeAngelo, David P. Steensma, Richard M. Stone, Donna S. Neuberg, Daniel A. Arber
Journal: Blood (2013)
Improve your health and fitness in ‘Just 6 weeks’
Authors: Lucía Sagarra Romero, Antonio Monroy Antón
Journal: British Journal of Sports Medicine (2016)

Just 6 weeks.

Health and wellness.

Android, iOS.

Android €2.21, iOS €1.99.

The ‘Just 6 weeks’ app allows users to get in shape and reach their goals. It tests their fitness level and determines which exercises could be better depending on the type of athlete they are. The app includes five programmes (figure 1): 100 push-ups, 200 sit-ups, 200 squats, 150 dips and 20 pull ups, of which …
The RUNX1-Regulated Cebpa +37 Kb Enhancer Directs Human CD4 Transgene Expression To Long-Term Hematopoietic Stem Cells and Preferentially To Myeloid Compared With Lymphoid Or Erythroid Progenitors
Authors: Alan D. Friedman, Hong Guo, Ou Ma, Leonard I. Zon, Ilya Shestopalov, Dan S. Kaufman, Patrick I Ferrell
Journal: Blood (2013)
"Ultrashort" control of hypothalamic hormones secretion : a brief history
Authors: F. Piva, M. Zanisi, M. Motta, L. Martini
Journal: Journal of Clinical Investigation (2004)

Some 30 years ago we proposed that the synthesis of the hypothalamic releasing factors (RFs) might be influenced by changes of their own titers in the general circulation and in the hypothalamus. At that time the dominating concept was that there were two different hypothalamic RFs controling respectively follicle-stimulating hormone (FSHRF) and luteinizing hormone (LHRF). The possible existence of the first ultrashort feedback system was proposed on the basis of the observation that in male rats castrated, to eliminate the long feedback effect of testosterone, and then hypophysectomized, to abolish the possible short feedback effect of pituitary hormones on the hypothalamus, the intrahypothalamic levels of FSHRF resulted to be higher than in controls. Following a treatment with an hypothalamic extract, the intrahypothalamic stores of FSHRF returned to pre-operation levels, suggesting that a factor present in the hypothalamic extract might exert an inhibitory influence on the synthesis of FSHRF. In 1987, we confirmed these findings using an in vitro perfusion system of rat hypothalamic tissue, where the amount of gonadotropin-releasing hormone (GnRH) released was measured in the effluent. When a GnRH analog was added to the perfusion medium, both the spontaneous and the stimulated release of GnRH were totally obliterated. The presence of specific binding sites for GnRH has been clearly demonstrated in GnRH neurons. It is becoming consequently attractive the hypothesis that paracrine interactions might occur among GnRH neurons, entertaining an ultrashort feedback control of GnRH secretion.
18F-FDG PET/CT Brain Imaging on a Patient With Paraneoplastic Opsoclonus-Myoclonus Syndrome Arising out of a Mature Cystic Teratoma
Authors: Chang Ju Na, Young Jin Jeong, Seok Tae Lim, Myung-Hee Sohn, Hwan-Jeong Jeong
Journal: Clinical Nuclear Medicine (2015)

Opsoclonus-myoclonus syndrome (OMS) is an involuntary multidirectional eye movement accompanied by myoclonic jerks and a subtype of paraneoplastic neurological syndromes. Clinical features of OMS include opsoclonus with myoclonic jerks and cerebellar ataxia. Although there have been a few studies on brain FDG PET in paraneoplastic neurological syndrome associated with some kinds of malignancies such as lung and gastric cancer, brain FDG PET of patients with OMS caused by a mature cystic teratoma has not been reported. Here, we described a case of brain FDG PET/CT studies performed in a woman with OMS provoked from a mature cystic teratoma.
Radiology — A Case Study in Technology and Manpower
Authors: John H. Knowles
Journal: New England Journal of Medicine (1969)

Possibilities in the Resolution of the IssuesWhere does one start to break this self-defeating cycle? If more time is spent by radiologists in personal contact with patients, manpower shortages will be accentuated. There simply are not enough radiologists to spend the added time required to establish radiology as a direct, personal patient-care profession. The referring physician, moreover, does not want his history and physical examination repeated, nor is the radiologist prepared to take complete care of the (hospitalized) patient, and the patient may suffer from too much meddling by too many doctors. The thrust to assume more nearly the . . .
Measurement of urinary incontinence after prostate surgery from data-mining electronic health records (EHR).
Authors: Tina Hernandez-Boussard, Suzanne Tamang, James D. Brooks, Douglas W Blayney, Nigam Shah
Journal: Journal of Clinical Oncology (2014)

6612 Background: National initiatives to develop quality metrics emphasize the need to include patient-centered outcomes, yet rely on manual chart abstraction or administrative data. Chart abstraction is expensive and labor intensive, while administrative data are incomplete. We sought to use EHR to examine post-operative urinary incontinence (PO-UI) as a patient-centered outcome, as this is prevalent in prostate cancer patients (reported ranges are 10% to 40%) yet rarely recorded in administrative data. Methods: We included patients who underwent prostatectomy at the Stanford Cancer Institute (SCI), 1995 - 2013. We processed clinician-generated encounter notes from EHRs using a validated text-mining workflow to measure PO-UI (PloS one. 2013;8(5):e63499). Our analysis included coded data (ICD-9-CM and CPT codes) as well as term-mentions extracted from unstructured clinicians’ notes. Results: We identified 5,353 patients who underwent prostatectomy; 43.8% open, 7.2% robot-assisted, 7.7% laparoscopic, and 41.3% were other, which includes codes that do not distinguish between robotic and laparoscopic procedures. 37.1% of our patients, treated prior to EHR implementation, were without an EHR note. UI was identified pre-surgery in 6.99% of patients and post-surgery in 9.66% of patients. Using only coded data, rates dropped to 0.24% pre-surgical and 0.21% post-surgical. In patients with an EHR clinical note (3,367 patients, 62.9%), PO-UI was identified in 22.6% of patients; 19.7% open, 12.7% robot-assisted, 21.5% laparoscopic, and 29.5% other surgeries (p<0.0001). 47% of all PO- UI were identified within 60 days of surgery. 20.8% of patients had documentation of no PO-UI. 44.2% of patients had pre-operative discussion of PO-UI documented as a possible complication. Conclusions: Using EHR to identify quality metrics is feasible, efficient and can capture patient-centered outcomes. Our results indicate that patient-centric events are not always coded in EHR and therefore not entered into administrative datasets; thus escaping quality assessment. Using EHRs for quality assessment promotes meaningful use of health information technology and allows quality measurement to move into the Big Data era.
A scalable platform for clinical immunophenotyping: assay design and quality control for high complexity flow cytometry
Authors: Yoshinobu Koguchi, Tanisha Meeuwsen, Iliana Gonzalez, William Miller, Keith S Bahjat
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts In the early 1980's it was demonstrated that density gradient isolation of peripheral blood mononuclear cells led to an unpredictable loss of lymphocyte populations and unacceptable levels of error for even routine CD4+ and CD8+ T cell enumeration. The error associated with this
Infection in Laboratory Animals with Pleuropneumonia-like Organisms<xref ref-type="fn" rid="FN1">1</xref>
Authors: John B. Nelson, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1958)

Infection in Laboratory Animals with Pleuropneumonia-like Organisms Get access John B. Nelson, Ph.D. John B. Nelson, Ph.D. Rockefeller Institute for Medical Research, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 5, May 1958, Pages 911–919, https://doi.org/10.1093/jnci/20.5.911 Published: 01 May 1958
Summary of Patterns of Mammalian Gene Action&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;
Authors: Sewall Wright
Journal: JNCI Journal of the National Cancer Institute (1954)

Summary of Patterns of Mammalian Gene Action Get access Sewall Wright Sewall Wright The University of Chicago, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 837–851, https://doi.org/10.1093/jnci/15.3.837 Published: 01 December 1954