tbuckley/cabot-search huggingface dataset:
THU0288 Osteoarticular Infections in Elderly Patients: A Study of 44 Cases
Authors: H. Sahli, I. Cherif, R. Tekaya, M. Maiza, I. Mahmoud, O. Saidane, L. Abdelmoula, R. Zouari
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Joint and bone infections are a therapeutic emergency that may occurs at any age but is particular among elderly patients. <h3>Objectives</h3> The aim of this study is to identify different features of joint and bone infections in elderly patients. <h3>Methods</h3> We performed a retrospective study of medical records of patients hospitalized for management of osteoarticular infections and who were aged more than 65 years old between 2000 and 2012. Clinical, paraclinical and therapeutic characteristics were recorded and analysed. <h3>Results</h3> Forty four cases were collected (20 males/24 females). Mean age was 73.8 years (range 65 to 90). The predisposing factors were present in 54,4% of cases (n=24): diabetes mellitus (n=9), renal failure (n=5), cirrhosis (n=3), rheumatoid arthritis (n=2), psoriatic arthritis (n=1), high dose corticoid intake (n=4). Tuberculous and brucellar contage were reported by 4 and 2 patients respectively. Infectious gateway were found in 5 cases: pulmonary (n=2), cutaneous (n=2) and urinary (n=1). Pain was present in all cases. The following symptoms were observed: fever (n=25), impaired general condition (n=20), night sweat (n=13), radiculalgia with neurological signs (n=6). Inflammatory blood tests were rised in all cases with mean CRP of 113.2mg/l (range 4 to 331) and mean ESR of 101.3mm (range 2 to 195). Blood culture was positive in 2 cases and wright serology was positive in 2 cases. Radiological abnormalities were found in 38 of cases. It was an infectious spondylodiscitis in 25 cases, an association of spondylodiscitis and septic arthritis of sternocostal joint in 1 case and a septic arthritis in 18 cases. In the last cases, it was: polyarthritis (n=1), oligoarthritis (n=2) and monoarthritis (n=15). The arthritis involved the: Knee (n=12), elbow (n=2), shoulder (n=2), ankle (n=3) and hip (n=1). The germ was identified in 10 cases: Specific germ in 1 case (Mycobacterium Tuberculosis), and pyogenic germ in 9 cases: Staphylococus (n=3), Pseudomonas (n=1), Escherichia coli (n=1), Streptococcus (n=1), Serratia (n=1), Lactococcus (n=1) Enterobacter (n=1). All patients received antibiotics according to the bacterial agents. Complications were observed in 6 cases: endocarditis (n=1), cauda equina syndrome (n=1), medullar cord compression (n=1) and side therapy effects (n=3). Five patients died. <h3>Conclusions</h3> Osteoarticular infections in elderly patients were dominated by spondylodiscitis, characterised by blood inflammation and may cause several complications. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2755
An Inter-Familial Outbreak of<i>Yersinia enterocolitica</i>Enteritis
Authors: L. T. Gutman, E. A. Ottesen, T. J. Quan, P. S. Noce, S. L. Katz
Journal: New England Journal of Medicine (1973)

Abstract An outbreak of Yersinia enterocolitica enteritis involved 16 of 21 persons in four related and neighboring families. The illness, which led to two appendectomies and two deaths, was characterized by fever (87 per cent), diarrhea (69 per cent), severe abdominal pain (62 per cent), vomiting (56 per cent), pharyngitis (31 per cent), headache (18 per cent) and leukocytosis. Four children had acute depression of serum albumin, with spontaneous recovery to normal levels after hospitalization. One child demonstrated an elevated total IgM antibody level. Serologic studies of 18 members of the families all demonstrated a positive response by the passive hemagglutination test. Eight persons had diagnostically important titers of 1:512 or greater, and all had symptomatic illness. The source of infection was suggested to have been a bitch and its litter of sick puppies. The sequential onset of disease indicated that, once it had been introduced into the households, person-to-person transmission had occurred....
PMO-188 Gender differences: analysis of 5162 colonoscopies over 4 years reveals higher caecal intubation rates in male patients
Authors: A M Verma, N McGrath, A Dixon, A P Chilton
Journal: Gut (2012)

<h3>Introduction</h3> Colonoscopy is the gold standard assessment for large bowel mucosal pathology, but a complete examination is an essential requirement. Higher caecal intubation rates in male patients vs female patients have been shown in the literature.<sup>1–3</sup> Several theories are mooted for this difference such as female patients undergoing previous hysterectomy,<sup>1</sup> low BMI<sup>2</sup> and the suggestion that female patients have longer colons.<sup>3</sup> The published papers on this subject are mostly over 10 years old and colonoscopy practice has changed dramatically over the last decade in the UK. The Joint Advisory Group on Gastrointestinal endoscopy (JAG) has run a programme of continuous quality improvement by standardising training, peer review and audit. The Bowel Cancer Screening Programme (BCSP) has been rolled out since 2006. This large audit revisits this subject to see if the improvements in colonoscopic practice have evened out the differences. <h3>Methods</h3> Data were collected from all colonoscopies undertaken (symptomatic, surveillance and BCSP procedures) at Kettering General Hospital between 1 July 2007 and 30 June 2011. <h3>Results</h3> <h3>Conclusion</h3> Analysis of the data reveals significant differences in CIR between female and male patients (87.62% vs 92.73% (p≤0.0001) NNT 19.57). This large retrospective audit shows despite the improvements in training and practice overseen by JAG and the introduction of BCSP, significant gender differences remain in CIR. Perhaps it would be prudent for endoscopy units to delineate these differences in gender and the potential ramifications (missed polyps etc) when giving information and consenting patients for colonoscopy. Further analysis of the reasons resulting in gender differences in CIR and the impact on morbidity and mortality due to missed pathology would be desirable. <h3>Competing interests</h3> None declared. <h3>References</h3> 1. <b>Church JM</b>. Complete colonoscopy: How often? And if not, why not? <i>Am J Gastroenterol</i> 1994;<b>89</b>:556–60. 2. <b>Anderson JC</b>, Gonzalez JD, Messina CR, <i>et al.</i> Factors that predict incomplete colonoscopy: thinner is not always better. <i>Am J Gastroenterol</i> 2000;<b>95</b>:2784–7. 3. <b>Saunders BP</b>, Fukumoto M, Halligan S, <i>et al.</i> Why is colonoscopy more difficult in women? <i>Gastrointest Endosc</i> 1996;<b>43</b>:124–6.
Hormone Therapy in Premenopausal Women with Early-Stage Breast Cancer
Authors: Hope S. Rugo
Journal: New England Journal of Medicine (2014)

Breast cancer is the most frequent cancer diagnosis in women worldwide and the most common cause of death from cancer. In the United States, 21% of breast cancers are diagnosed in women younger than 50 years of age, affecting almost 49,000 women, and this disease remains a leading cause of death.1 The most common form of breast cancer is hormone-receptor–positive disease, and the incidence of this subtype, particularly among younger women, has increased in the past decade, probably owing to changes in lifestyle factors and diet. For these reasons, improving the outcome of hormone-receptor–positive breast cancer in young women is . . .
Genetic Targeting of Adenoviral Vectors
Authors: Victor N. Krasnykh, Joanne T. Douglas, Victor W. van Beusechem
Journal: Molecular Therapy (2000)

Gene therapy, which emerged in the late 1980s to early 1990s as an alternative approach to treat serious human illnesses incurable with current therapies, has by now proved its usefulness in a number of clinical trials aimed to develop a cure for several inherited and acquired genetic diseases including various types of cancer, coronary artery disease, and cystic fibrosis (1–9). However, during its development as a novel field of technology, gene therapy has revealed several limitations or shortcomings related to the very essence of the idea on which it is based—that is, efficient expression of a therapeutic gene in the disease-affected tissue in a human body.
THU0444 Health Related Quality of Life in Patients with EDS ? EDS and Health Related Quality of Life ?
Authors: A. I. Turrión, D. Mayan, A. Sellas, R. Martín-Holguera
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ehlers-Danlos Syndromes (EDS) are a group of hereditable disorders of connective tissue characterized by joint hypermobility, skin hyperextensibility and tissues fragility. Patients with EDS often show symptoms that affect of significant form their quality of life, but that are not totally recognized by the health professionals. <h3>Objectives</h3> The purpose of this study is to describe and to analyze the epidemiological characteristics and the health related quality of life (HRQOL) in patients with EDS. <h3>Methods</h3> We have realized a descriptive transversal study. We sent the Questionnaire of Health (MOS) SF-36 to investigate the health related quality of life, the Brief Pain Inventory for the Evaluation of the Pain (BPI-CBD), the scale of Intensity of the Fatigue (FSS) and a demographic questionnaire to 211 potential participants. In all the cases, the surveys were auto-administered, and the confidentiality of the information was kept to the maximum. The included variables evaluate demographic date, mobility, personal care, usual activity, pain, fatigue and distress / depression. The information was analyzed using SPSS 15.0 for Windows. To measure the reliability of the results we used Cronbach's alpha coefficient. <h3>Results</h3> We evaluated 126 questionnaires, which means a response of 59 %. 67,3 % was women and 32,7 %, males, with an average ages of 28,8 ± 10,9 years. 11,5 % presented a very impaired HRQOL, 46,2 % moderately impaired and 42,3 % lightly impaired. Only 4,8 % of the survey respondents indicated that EDS does not affect their activities of the daily life. Practically in all aspects, the HRQOL in patients with EDS was significantly worse than is considered to be normal in the general population. <h3>Conclusions: Conclusions</h3> In our study it is demonstrated that the physical functioning, the pain and the emotional role are the fields with a more significant impact, therefore we can conclude that the injuries, the pain, the fatigue and the anxiety / depression are possible factors that contribute to the limited quality of life in the patients with EDS. The health professionals should use a multidisciplinary approach to treat with efficiency the symptoms that appear associated to EDS, and in this way to help to improve the quality of life of patients with EDS. <h3>Acknowledgements</h3> We thank the asedh patients for their cooperation partnership. <h3>Disclosure of Interest</h3> None Declared
AB0010 Hla-g 14-bp insertion/deletion polymorphism modulates MTX therapeutic effect in a cohort of patients with rheumatoid arthritis: Table 1.
Authors: C. Brenol, T.D. Veit, P. Martineli, J.C. Brenol, C. Silva, C. Hinckel, J.A. Chies, R. Xavier
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In recent years, a convincing body of scientific evidence has indicated that the expression of human leukocyte antigen-G (HLA-G), a non-classical major histocompatibility complex (MHC) class I molecule, plays a role in regulation of inflammation in autoimmune diseases [1]. Polymorphisms in this gene, therefore, are reasonable candidates for susceptibility and pharmacogenetics studies in RA. <h3>Objectives</h3> We sought to determine whether the 14-bp insertion/deletion polymorphism in exon 8 of the HLA-G gene is associated with susceptibility to RA, clinical features, or response to MTX therapy. <h3>Methods</h3> We determined the HLA-G 14-bp insertion/deletion polymorphism genotypes in a prospective cohort of 309 consecutive RA patients and 294 healthy controls, and looked for associations between genotype and clinical features of RA. Multivariate analyses were performed to investigate the effect of homozygosity for the -14/-14 bp genotype on changes in DAS28 in response to MTX therapy in a subgroup of 188 RA patients. <h3>Results</h3> Among the 309 RA patients, no correlations were observed between allele or genotype frequencies of the HLA-G gene polymorphism and clinical features, including disease activity scores and functional scores. No significant differences were observed in the genotype and allele frequencies between RA patients and controls. In the subgroup evaluated for clinical response to MTX, we observed a decrease in mean DAS28 over the course of the study. Furthermore, a better response to MTX treatment, measured by adjusted mean of DAS28 change, was observed in those patients with the HLA-G -14/-14-bp genotype, which was not observed among other genotypes (table 1). <h3>Conclusions</h3> Homozygosity for the 14 bp deletion polymorphism within exon 8 of the HLA-G gene was associated with a better response to MTX in a prospective cohort of patients with RA. This is a plausible genetic marker for predicting response to MTX therapy in RA. <h3>References</h3> Baricordi, O.R., et al., HLA-G and inflammatory diseases. Inflamm Allergy Drug Targets. 2008, 7(2): p. 67-74. <h3>Disclosure of Interest</h3> None Declared
AB0916 Comparison of clinical, biological and radiological features in male and female patients with ankylosing spondylitis:
Authors: W. Hamdi, M.M. Ghannouchi, Z. Alaya, I. Zouch, M.M. Kchir
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ankylosing spondylitis (AS) is a chronic inflammatory disease affecting traditionally young male. AS frequently involves the axial skeleton, and can result in abnormal bone formation with eventual ankylosis of the spine, resulting in substantial disability and functional limitation. Female AS is known to be less severe than in male patients. <h3>Objectives</h3> To compare of clinical, biological and radiological features in male and female patients with ankylosing spondylitis. <h3>Methods</h3> A cross sectional study was conducted in our department of Rheumatology that includes 165 patients (136 male/29 female) with ankylosing spondylitis according to the modified New York Criteria for AS. Clinical, biological and radiological data are collected. <h3>Results</h3> Patients mean age were 38,35±11 years [16-73]. Female were older than male patients (the mean age respectively 40/35 years). Comparison between male and female patients was displayed in table 1. <h3>Conclusions</h3> Clinical feature of AS were comparable in male and female patients. Only age of onset was earlier and HLA B27 was more frequent in male patients than in female. <h3>Disclosure of Interest</h3> None Declared
Liver Disease and Common-Bile-Duct Stenosis in Cystic Fibrosis
Authors: Kevin J. Gaskin, Donna L.M. Waters, Robert Howman-Giles, Merl De Silva, John W. Earl, Hugh C.O. Martin, Alex E. Kan, John M. Brown, Stuart F.A. Dorney
Journal: New England Journal of Medicine (1988)

To determine the incidence of common-bile-duct lesions and their relation to liver disease in cystic fibrosis, we performed hepatobiliary scanning in 50 of 61 patients with cystic fibrosis who had hepatomegaly, abnormal liver function, or both and in 31 of 92 patients with cystic fibrosis who did not have hepatomegaly or abnormal liver function. Ninety-six percent of the patients with liver disease had evidence of biliary tract obstruction, which was defined cholangiographically as a stricture of the distal common bile duct in the majority of cases. All the patients without liver disease had normal intrahepatic and common-duct excretion of tracer. Abdominal pain was significantly more common in patients with common-duct obstruction (P<0.001), and enlarged gallbladders occurred only in such patients. Since fasting levels of serum bile acids were elevated in nearly half these patients, irrespective of the severity of their liver disease, serum bile acids may be markers of the severity of the common-duct lesion. We conclude that strictures of the distal common bile duct are common in patients with cystic fibrosis and liver disease. This association requires further study, since surgical relief of common-duct obstruction may prevent or ameliorate the hepatic complications of cystic fibrosis. (N Engl J Med 1988; 318:340–6.)
Melanoma in Children
Authors: Patricia I. Ceballos, Ramon Ruiz-Maldonado, Martin C. Mihm
Journal: New England Journal of Medicine (1995)

To give a child the ominous diagnosis of malignant melanoma is a very difficult decision for both clinician and pathologist. Difficulties in histologic diagnosis combined with a reluctance on the part of the clinician may lead to delays in diagnosis and curative surgical intervention. In fact, some melanomas in children are misdiagnosed clinically as benign lesions and recognized as melanomas only after excision. It is imperative to recognize that malignant melanoma occurs in children and to appreciate its clinical characteristics and predisposing factors.Incidence and PrognosisApproximately 2 percent of melanomas occur in patients under the age of 20 years, . . .
Subcutaneous Dissemination of B Cell Lymphoma Shown by Tc-99m Sestamibi
Authors: TSUNEO HIRANO, MASATOSHI ABE, MASASHI WARITA, MASASHI YUKIHIRO, HIDEKI SUZUKI, NAOYUKI WATANABE, NOBORU ORIUCHI, KEIGO ENDO
Journal: Clinical Nuclear Medicine (1996)

A 65-year-old man was treated for B cell lymphoma for 1.5 years. He noticed several erythematous subcutaneous nodules in the upper and lower extremities bilaterally. There was a small palpable lymph node in the right axillary region with mild tenderness and bilateral inguinal adenopathy. Biopsy of a subcutaneous nodule showed recurrent B cell lymphoma. Ga-67 citrate scintigraphy showed multiple areas of increased uptake in the soft tissue of the bilateral upper and lower extremities. There was diffusely increased uptake in the liver, spleen, and axial skeleton. Tc-99m sestamibi scintigraphy showed multiple areas of increased uptake in the subcutaneous soft tissue of the upper and lower extremities and lymph nodes. There also was increased uptake in the salivary glands, thyroid gland, heart, and liver. Excreted activity was physiologically noted in the intestine and urinary bladder.
Abstract 4974: Oligoclonal characterization of tumor-infiltrating plasma cells in breast cancer: Germ cell expansion and immunity .
Authors: Anurag Shukla, Yu-Jing Sun, David Krag
Journal: Cancer Research (2013)

Abstract Breast cancer is the most common invasive cancer in women in the United States and many other parts of the world. About 80% of all the breast cancers are Invasive Ductal Carcinomas (IDC). Breast cancers often show detectable lymphocytic infiltrates, and only about one-fourth of them contain moderate to heavy infiltration of B-cells and plasma cells. B cells are the effector cells of humoral immunity and can terminally differentiate into antibody secreting plasma cells. In the present study, we have analyzed the immunoglobulin variable genes of tumor-infiltrating plasma cells from IDC patients. This was done to determine the clonal character of the plasma cells and their possible role in the tumor immunity. Fresh malignant breast tumors were obtained following surgery, and their frozen sections were screened for the lymphocytic infiltration. The tumor samples from patients which showed good plasma cell-infiltration were used for this study. Both malignant breast tumors, A55 (estrogen receptor-positive 80%; progesterone receptor-positive &amp;gt;90%) and A91 (estrogen receptor positive 70%; progesterone receptor positive 90%), were categorized as invasive ductal carcinomas. Using a laser capture microdissection technique (PALM Microlaser Technologies AG, Bernried, Germany), single and small clusters of plasma cells in the tumors were collected. The tumor plasma cells were processed for human immunoglobulin variable gene analysis using appropriate RT-PCR primer sets for heavy and light chains. A set of B- cells from healthy volunteer blood was also run as a RT-PCR quality control. The analyses of variable regions (VHeavy and VLight) of immunoglobulin genes show a very limited number of plasma cell clones in both the tumors. These results indicate their origin from a possible B-cell germ center within the tumor. These plasma cells may be secreting antibodies relevant to the tumor antigens. In order to confirm this, we plan to clone these VH and VL genes and produce antibodies in vitro and examine their binding to the tumor from which they were derived. The work will be extended to study the effects of these antibodies on breast cancer cell proliferation. Citation Format: Anurag Shukla, Yu-Jing Sun, David Krag. Oligoclonal characterization of tumor-infiltrating plasma cells in breast cancer: Germ cell expansion and immunity . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4974. doi:10.1158/1538-7445.AM2013-4974
1971–1991: Virus Cancer Research Pays Rich Dividends
Authors: Elaine Blume
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article 1971–1991: Virus Cancer Research Pays Rich Dividends Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 21, 6 November 1991, Pages 1528–1531, https://doi.org/10.1093/jnci/83.21.1528 Published: 06 November 1991
Marker Genes Face Long Road to the Clinic
Authors: N. J. Nelson
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Marker Genes Face Long Road to the Clinic Get access Nancy J. Nelson Nancy J. Nelson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 17, 6 September 1995, Pages 1282–1283, https://doi.org/10.1093/jnci/87.17.1282 Published: 06 September 1995
INCREASED EXERCISE PERIPHERAL EXTRACTION IN GROUP 2 PULMONARY HYPERTENSION AND EXERCISE OSCILLATORY VENTILATION
Authors: Greta Generati, Bandera Francesco, Marta Pellegrino, Valentina Labate, Valeria Donghi, Vincenzo Tufaro, Eleonora Alfonzetti, Marco Guazzi
Journal: Journal of the American College of Cardiology (2016)
Facteurs prédictifs de diagnostic positif par la vidéo-capsule du grêle chez 749 patients présentant un saignement digestif inexpliqué (obscur ou occulte)
Authors: L Lepileur, M Antonietti, S Grigioni, A Di Fiore, R Alhameedi, I Iwanicki-Caron, P Ducrotté, S Lecleire
Journal: Endoscopy (2012)

La vidéo-capsule du grêle (VCE) est à ce jour le meilleur examen non-invasif permettant d'explorer l'intestin grêle dans son intégralité, avec un rendement diagnostique établi de 50 à 70% chez les patients présentant un saignement digestif obscur-occulte ou inexpliqué (1). Les patients présentant un saignement digestif inexpliqué (SDI) peuvent être séparés en deux groupes: les patients présentant un saignement extériorisé tel qu'un méléna ou des rectorragies (saignement obscur) et les patients présentant un saignement occulte, caractérisés par une anémie ferriprive isolée. But de l'étude: identifier dans une étude rétrospective les facteurs prédictifs de diagnostic positif par la VCE chez des patients présentant un SDI.