tbuckley/cabot-search huggingface dataset:
Screening for anxiety and depression in people with psoriasis: a cross-sectional study in a tertiary referral setting
Authors: R.C. Lamb, F. Matcham, M.A. Turner, L. Rayner, A. Simpson, M. Hotopf, J.N.W.N. Barker, K. Jackson, C.H. Smith
Journal: British Journal of Dermatology (2016)

National Institute for Health and Care Excellence guidance recommends assessment of psychological and social well-being in people with psoriasis.To screen systematically for depression and anxiety in patients with psoriasis in routine clinical practice and to identify at-risk groups for psychiatric morbidity.Consecutive patients attending a single, tertiary centre over a 10-month period were invited to complete the Patient Health Questionnaire Depression Scale (PHQ-9), Generalized Anxiety Disorder Scale (GAD-7) and Dermatology Life Quality Index (DLQI) as part of IMPARTS: Integrating Mental and Physical Healthcare: Research, Training and Services. Information on demographics, treatment and clinical disease severity was collated from electronic patient records. Regression models were used to identify at-risk groups for psychiatric morbidity.Of 607 patients included (56·2% on biologics), 9·9% (95% confidence interval 7·5-12·3%) screened positive for major depressive disorder (MDD) and 13·1% (79/604) (95% confidence interval 10·4-15·8%) for generalized anxiety disorder (GAD; GAD-7 score > 9). Suicidal ideation was reported in 35% of those with MDD; DLQI was < 10 in 38·3% and 45·6% cases of MDD and GAD, respectively. After adjusting for covariates, the risk of MDD or GAD was significantly higher in women and those with severe clinical disease, psoriatic arthritis and previous depression/anxiety. The risk of GAD was significantly increased with Asian ethnicity and use of topical treatments only.Systematic screening for anxiety and depression identifies clinically important levels of depression and anxiety that may be missed using DLQI data alone. Women and those with severe disease, psoriatic arthritis and/or a prior history of psychiatric morbidity may be at particular risk.
Has the 67Ga-SPET a Role in Monitoring Hodgkin and Primary Mediastinal Lymphoma in the PET-FDG Age?.
Authors: Isabella Palumbo, Giorgia Desantis, Barbara Palumbo, Lorenzo Falchi, Paola Cerroni, Vincenzo Capparella, Michele Cianciulli, Renato Palumbo, Anna M. Liberati
Journal: Blood (2005)
Cost of limiting abortion [letter]
Authors: Simms M
Journal: BMJ (1988)

By focusing on the large public health and social service cost implications of David Altons Abortion (Amendment) Bill Caroline Woodroffe and Dr. Valerie Beral have provided a public service.  Woodroffe and Beral acknowledge that their figures are conservative because the costs of medical care and family support are excluded yet their calculations are based on 1983 figures which have risen.  They do not address the emotional costs.  This writer interviewed a small group of mothers in east London and Essex in 1985.  These women had cared for severely handicapped children immediately before the passage of the Abortion Act.  The children now ranged in age between 19-25.  2/3 of the mothers interviewed indicated that they would have opted for abortion had it been available to them at that time.  Several of the mothers had given up all hopes of returning to work costing these families a lifetimes earnings.  This cost also was excluded from the calculations of Woodroffe and Beral.  According to the most recent poll 87% of the population supports late abortion on the grounds of handicap.
Induction of Macrophage Tumoricidal Activity, Major Histocompatibility Complex Class II Antigen (Ia<sup>k</sup>) Expression, and Interleukin-1 Production by Swainsonine
Authors: K Grzegorzewski, S A Newton, S K Akiyama, S Sharrow, K Olden, S L White
Journal: Cancer Communications (1989)

Previous studies in our laboratory have shown that the reported antitumor activity of systemically administered swainsonine, an indolizidine alkaloid, is due at least in part to immune modulation involving effector cells (Humphries, M.J.; Matsumoto, K; White, S.L.; Olden, K. Cancer Res. 48:1410-1415; 1988 and White, S. L.; Schweitzer, K.; Humphries, M.J.; Olden, K. Biochem. Biophys. Res. Commun. 150:615-625; 1988). In this report, studies are presented to show that swainsonine was effective in activating peritoneal macrophages to cytotoxicity against tumor cells. Stimulation of tumoricidal activity of macrophages was associated with increased secretion of interleukin-1 (IL-1) and expression of the Iak major histocompatibility complex (MHC) antigen on the cell surface. The 3-fold stimulation of cytotoxicity observed in these in vivo studies was comparable to that obtained with Corynebacterium parvum, a commonly used in vivo activating agent. The in vitro incubation of thioglycollate-elicited peritoneal macrophages with swainsonine consistently resulted in levels of activation (6- to 8-fold) comparable to that obtained by treatment with known in vitro macrophage activating agents such as lipopolysaccharide (LPS) or recombinant gamma-interferon (rIFN-gamma). The stimulation observed by using swainsonine in combination with LPS was additive, suggesting different mechanisms of action. These studies have important implications not only for treatment of cancer, infectious diseases, and immune suppressive disorders, but also for elucidation of the mechanism of macrophage activation.
Early-Life Exposure to the Great Smog of 1952 and the Development of Asthma
Authors: Prashant Bharadwaj, Joshua Graff Zivin, Jamie T. Mullins, Matthew Neidell
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Little is known about the long-term effects of air pollution exposure and the root causes of asthma. We use exposure to intense air pollution from the 1952 Great Smog of London as a natural experiment to examine both issues.To determine whether exposure to extreme air pollution in utero or soon after birth affects asthma development later in life.This was a natural experiment using the unanticipated pollution event by comparing the prevalence of asthma between those exposed to the Great Smog in utero or the first year of life with those conceived well before or after the incident and those residing outside the affected area at the time of the smog.Prevalence of asthma during childhood (ages 0-15) and adulthood (ages >15) is analyzed for 2,916 respondents to the Life History portion of the English Longitudinal Study on Aging born from 1945 to 1955. Exposure to the Great Smog in the first year of life increases the likelihood of childhood asthma by 19.87 percentage points (95% confidence interval [CI], 3.37-36.38). We also find suggestive evidence that early-life exposure led to a 9.53 percentage point increase (95% CI, -4.85 to 23.91) in the likelihood of adult asthma and exposure in utero led to a 7.91 percentage point increase (95% CI, -2.39 to 18.20) in the likelihood of childhood asthma.These results are the first to link early-life pollution exposure to later development of asthma using a natural experiment, suggesting the legacy of the Great Smog is ongoing.
P-149 Impact of sequence of biologic therapies on overall survival (OS) in patients with RAS wild-type (WT) metastatic colorectal carcinoma (mCRC): an exploratory, retrospective pooled analysis
Authors: A. Sobrero, J.-Y. Douillard, F. Rivera, F. Forget, M. Karthaus, M. Valladares-Ayerbes, G. Demonty, X. Guan, M. Peeters
Journal: Annals of Oncology (2016)
Update: influenza activity - United States, August 30, 2009-January 9, 2010.
Authors: L. Brammer, S. Epperson, L. Blanton, T. Wallis, A. Fiore, L. Gubareva, J. Bresee, L. Kamimoto, X. Xu, A. Klimov, N. Cox, L. Finelli, S. Graitcer
Journal: MMWR Morbidity and Mortality Weekly Report (2010)
Case 38-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Richard A. Rudders, Gary C. Stone
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 73-year-old man was admitted to the hospital because of anorexia and weight loss.He was in excellent health until 10 months earlier, when a chronic cough developed and was productive of small amounts of clear sputum. Five months before entry anorexia, fatigue, and malaise occurred, with polydipsia, polyuria, and nocturia three or four times nightly.Two weeks before admission he entered another hospital. The hematocrit was 32.1 percent, and the mean corpuscular volume was 86 μm3 per cell. The white-cell count was 5200, with 62 percent neutrophils, 18 percent band forms, 3 percent juvenile forms, 12 . . .
Variation in Infectivity and Virus-Particle Content of Individual Plasmas from Birds with Erythromyeloblastic Leukosis&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Edward A. Eckert, D. G. Sharp, Dorothy Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Variation in Infectivity and Virus-Particle Content of Individual Plasmas from Birds with Erythromyeloblastic Leukosis Get access Edward A. Eckert, Edward A. Eckert Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. G. Sharp, D. G. Sharp Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar Dorothy Beard, Dorothy Beard Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Beard J. W. Beard Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 2, October 1952, Pages 533–542, https://doi.org/10.1093/jnci/13.2.533 Published: 01 October 1952 Article history Received: 16 June 1952 Published: 01 October 1952
68Ga-PSMA-11 PET Represents the Tumoricidal Effect of 223Ra in a Patient With Castrate-Resistant Metastatic Prostate Cancer
Authors: Hojjat Ahmadzadehfar, Carl Diedrich Schlenkhoff, Sebastian Rogenhofer, Anna Yordanova, Markus Essler
Journal: Clinical Nuclear Medicine (2016)

A 64-year-old man with prostate cancer and an increasing prostate-specific antigen (PSA) level under therapy with abiraterone acetate underwent a therapy with Ra. Before the first therapy and 4 weeks after the last cycle, the patient underwent Ga-PSMA PET, which showed a clear response of bone metastases.
ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds
Authors: Rolake O. Alabi, Krzysztof Glomski, Coline Haxaire, Gisela Weskamp, Sébastien Monette, Carl P. Blobel
Journal: Circulation Research (2016)

Endothelial Notch signaling is critical for early vascular development and survival. Yet, previously described mice lacking endothelial a disintegrin and metalloproteinase 10 (ADAM10), a key regulator of Notch signaling, survived into adulthood with organ-specific vascular defects. These findings raised questions about whether these vascular defects were related to Notch signaling or other functions of ADAM10.The aims of the study are to determine whether compensatory or redundant functions of ADAM17 in Notch signaling can explain the survival of Adam10ΔEC mice, explore the contribution of different Tie2-Cre transgenes to the differences in survival, and establish whether the Adam10ΔEC vascular phenotypes can be recapitulated by inactivation of Notch receptors in endothelial cells.Mice lacking ADAM10 and ADAM17 in endothelial cells (Adam10/Adam17ΔEC), which survived postnatally with organ-specific vascular defects, resembled Adam10ΔEC mice. In contrast, Adam10ΔEC mice generated with the Tie2Cre transgene previously used to inactivate endothelial Notch (Adam10ΔEC(Flv)) died by E10.5. Quantitative polymerase chain reaction analysis demonstrated that Cre-mediated recombination occurs earlier in Adam10ΔEC(Flv) mice than in the previously described Adam10ΔEC mice. Finally, mice lacking endothelial Notch1 (Notch1ΔEC) share some organ-specific vascular defects with Adam10ΔEC mice, whereas Notch4(-/-) mice lacking endothelial Notch1 (Notch1ΔEC/Notch4(-/-)) had defects in all vascular beds affected in Adam10ΔEC mice.Our results argue against a major role for ADAM17 in endothelial Notch signaling and clarify the difference in phenotypes of previously described mice lacking ADAM10 or Notch in endothelial cells. Most notably, these findings uncover new roles for Notch signaling in the development of organ-specific vascular beds.
An Autotaxin/Lysophosphatidic Acid/Interleukin‐6 Amplification Loop Drives Scleroderma Fibrosis
Authors: Flavia V. Castelino, Gretchen Bain, Veronica A. Pace, Katharine E. Black, Leaya George, Clemens K. Probst, Lance Goulet, Robert Lafyatis, Andrew M. Tager
Journal: Arthritis & Rheumatology (2016)

We previously implicated the lipid mediator lysophosphatidic acid (LPA) as having a role in dermal fibrosis in systemic sclerosis (SSc). The aim of this study was to identify the role of the LPA-producing enzyme autotaxin (ATX), and to connect the ATX/LPA and interleukin-6 (IL-6) pathways in SSc.We evaluated the effect of a novel ATX inhibitor, PAT-048, on fibrosis and IL-6 expression in the mouse model of bleomycin-induced dermal fibrosis. We used dermal fibroblasts from SSc patients and control subjects to evaluate LPA-induced expression of IL-6, and IL-6-induced expression of ATX. We next evaluated whether LPA-induced ATX expression is dependent on IL-6, and whether baseline IL-6 expression in fibroblasts from SSc patients is dependent on ATX. Finally, we compared ATX and IL-6 expression in the skin of patients with SSc and healthy control subjects.PAT-048 markedly attenuated bleomycin-induced dermal fibrosis when treatment was initiated before or after the development of fibrosis. LPA stimulated expression of IL-6 in human dermal fibroblasts, and IL-6 stimulated fibroblast expression of ATX, connecting the ATX/LPA and IL-6 pathways in an amplification loop. IL-6 knockdown abrogated LPA-induced ATX expression in fibroblasts, and ATX inhibition attenuated IL-6 expression in fibroblasts and the skin of bleomycin-challenged mice. Expression of both ATX and IL-6 was increased in SSc skin, and LPA-induced IL-6 levels and IL-6-induced ATX levels were increased in fibroblasts from SSc patients compared with controls.ATX is required for the development and maintenance of dermal fibrosis in a mouse model of bleomycin-induced SSc and enables 2 major mediators of SSc fibrogenesis, LPA and IL-6, to amplify the production of each other. Our results suggest that concurrent inhibition of these 2 pathways may be an effective therapeutic strategy for dermal fibrosis in SSc.
Prevention Conference V
Authors: Philip Greenland, Jonathan Abrams, Gerard P. Aurigemma, M. Gene Bond, Luther T. Clark, Michael H. Criqui, John R. Crouse, Lawrence Friedman, Valentin Fuster, David M. Herrington, Lewis H. Kuller, Paul M. Ridker, William C. Roberts, William Stanford, Neil Stone, H. Jeremy Swan, Kathryn A. Taubert, Lewis Wexler
Journal: Circulation (2000)
Alemtuzumab can be Incorporated Into Front-Line Therapy of Adult Acute Lymphoblastic Leukemia (ALL): Final Phase I Results of a Cancer and Leukemia Group B Study (CALGB 10102).
Authors: Wendy Stock, Ben Sanford, Gerard Lozanski, Ravi Vij, John C. Byrd, Bayard L. Powell, Meir Wetzler, Dorie Sher, Colin Edwards, Michael Kelly, Sue Richards, Crystal Sung, Greg Malnassy, Eva Hoke, Clara D. Bloomfield, Richard A. Larson
Journal: Blood (2009)
Delayed hemolytic transfusion reaction in adult sickle‐cell disease: presentations, outcomes, and treatments of 99 referral center episodes
Authors: Anoosha Habibi, Armand Mekontso‐Dessap, Constance Guillaud, Marc Michel, Keyvan Razazi, Mehdi Khellaf, Btissam Chami, Dora Bachir, Claire Rieux, Giovanna Melica, Bertrand Godeau, Frédéric Galacteros, Pablo Bartolucci, France Pirenne
Journal: American Journal of Hematology (2016)

Delayed hemolytic transfusion reaction (DHTR) is one of the most feared complications of sickle-cell disease (SCD). We retrospectively analyzed the clinical and biological features, treatments and outcomes of 99 DHTRs occurring in 69 referral center patients over 12 years. The first clinical signs appeared a median of 9.4 [IQR, 3-22] days after the triggering transfusion (TT). The most frequent DHTR-related clinical manifestation was dark urine/hemoglobinuria (94%). Most patients (89%) had a painful vaso-occlusive crisis and 50% developed a secondary acute chest syndrome (ACS). The median [IQR] hemoglobin-concentration nadir was 5.5 [4.5-6.3] g/dL and LDH peak was 1335 [798-2086] IU/L. Overall mortality was 6%. None of the patients had been receiving chronic transfusions. Among these DHTRs, 61% were developed in previously immunized patients, 28% in patients with prior DHTR. Among Abs detected after the TT in 62% of the episodes, half are classically considered potentially harmful. No association could be established between clinical severity and immunohematological profile and/or the type and specificity of Abs detected after the TT. Management consisted of supportive care alone (53%) or with adjunctive measures (47%), including recombinant erythropoietin and sometimes rituximab and/or immunosuppressants. Additional transfusions were either ineffective or worsened hemolysis. In some cases, severe intravascular hemolysis can be likely responsible for the vascular reaction and high rates of ACS, pulmonary hypertension and (multi)organ failure. In conclusion, clinicians and patients must recognize early DHTR signs to avoid additional transfusions. For patients with a history of RBC immunization or DHTR, transfusion indications should be restricted. Am. J. Hematol. 91:989-994, 2016. © 2016 Wiley Periodicals, Inc.
104P Feasibility of dose-dense doxorubicin and cyclophosphamide (ddAC) followed by taxane (T) in Japanese women with early breast cancer: A retrospective study
Authors: J. Masuda, Y. Ozaki, H. Nakajima, R. Oki, M. Uchiyama, S. Koganemaru, T. Ogura, N. Tamura, Y. Miura, Y. Tanabe, D. Miura, H. Kawabata, T. Takano
Journal: Annals of Oncology (2015)
Hospitalization, inpatient burden and comorbidities associated with bullous pemphigoid in the U.S.A.
Authors: Z. Ren, D.Y. Hsu, J. Brieva, N.B. Silverberg, S.M. Langan, J.I. Silverberg
Journal: British Journal of Dermatology (2016)

Bullous pemphigoid (BP) is associated with significant disability and comorbid health disorders that may lead to or result from hospitalization. However, little is known about the inpatient burden and comorbidities of BP. To obtain data on the inpatient burden and comorbidities of BP in the U.S.A. We analysed data from the 2002 to 2012 National Inpatient Sample, including a representative 20% sample of all hospitalizations in the U.S.A. (72 108 077 adults). The prevalence of hospitalization for BP increased from 25·84 to 32·60 cases per million inpatients from 2002 to 2012. In multivariate logistic regression models with stepwise selection, increasing age, nonwhite ethnicity, higher median household income, being insured with Medicare or Medicaid, and increasing number of chronic conditions were all associated with hospitalization for BP (P < 0·05 for all). The top three primary discharge diagnoses for patients with a secondary diagnosis of BP were septicaemia (prevalence 5·51%, 95% confidence interval 5·03–5·99), pneumonia (4·60%, 4·19–5·01) and urinary tract infection (3·52%, 3·15–3·89). Patients with BP also had numerous autoimmune, infectious, cardiovascular and other comorbidities. Interestingly, BP was associated with multiple neuropsychiatric disorders, including demyelinating disorders, dementias (presenile, senile, vascular and other), paralysis, neuropathy (diabetic, other polyneuropathy), Parkinson disease, epilepsy, psychoses and depression. The mean annual age‐ and sex‐adjusted in‐hospital mortality rate was significantly higher in patients with a secondary diagnosis of BP compared with no BP (2·9%, range 2·8–3·9% vs. 2·1%, range 1·9–2·2%). Significant predictors of mortality in patients with BP included increasing age, nonwhite ethnicity and insurance with Medicaid or other payment status (P < 0·05 for all). Hospitalization for BP increased significantly between 2002 and 2012. Moreover, there were significant ethnic and healthcare disparities with respect to hospitalization and inpatient mortality from BP.
Case 6-1972
Authors: David C. Poskanzer, Edward P. Richardson
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 73-year-old woman was admitted to the hospital because of dehydration.For several years she had been treated with prednisone and chlorambucil because of chronic lymphocytic leukemia. During the six months before entry she experienced severe dysphagia with substernal burning, which was unrelated to exertion, was imperfectly relieved by antacids and largely prevented the ingestion of solid foods. She lost 11 kg in weight. Four months before admission she was treated for a febrile illness believed to be due to urinary-tract infection and cholecystitis, and mild dysuria persisted thereafter. Six weeks before entry, after a fall, peripheral . . .
Genome Wide Analysis of 41 Mycosis Fungoides Tumor Stage Using Array Comparative Genomic Hybridization Technology.
Authors: Rocio Salgado, Octavio Servitje, Fernando Gallardo, Maarten H Vermeer, Pablo Ortiz Romero, Marta Herrera, Maria Karpova, Cristina Muniesa, M. Pilar García-Muret, Teresa Estrach, Julia Sánchez-Schmidt, Vicenç Romagosa, Marie Zipser, Javier Suela, Bibiana I Ferreira, Juan Cigudosa, Carlos Barranco, Reinhard Dummer, Cornelis P Tensen, Sergi Serrano, Ramon M Pujol, Francesc Solé, Blanca Espinet
Journal: Blood (2008)
High type I error and misrepresentations in search for transgenerational epigenetic inheritance: response to Guerrero-Bosagna
Authors: Khursheed Iqbal, Diana A. Tran, Arthur X. Li, Charles Warden, Angela Y. Bai, Purnima Singh, Zach B. Madaj, Mary E. Winn, Xiwei Wu, Gerd P. Pfeifer, Piroska E. Szabó
Journal: Genome biology (2016)

In a recent paper, we described our efforts in search for evidence supporting epigenetic transgenerational inheritance caused by endocrine disrupter chemicals. One aspect of our study was to compare genome-wide DNA methylation changes in the vinclozolin-exposed fetal male germ cells (n = 3) to control samples (n = 3), their counterparts in the next, unexposed, generation (n = 3 + 3) and also in adult spermatozoa (n = 2 + 2) in both generations. We reported finding zero common hits in the intersection of these four comparisons. In our interpretation, this result did not support the notion that DNA methylation provides a mechanism for a vinclozolin-induced transgenerational male infertility phenotype. In response to criticism by Guerrero-Bosagna regarding our statistical power in the above study, here we provide power calculations to clarify the statistical power of our study and to show the validity of our conclusions. We also explain here how our data is misinterpreted in the commentary by Guerrero-Bosagna by leaving out important data points from consideration. Please see related Correspondence article: https://genomebiology.biomedcentral.com/articles/10.1186/s13059-016-0982-4 and related Research article: http://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0619-z