tbuckley/cabot-search huggingface dataset:
A Method of Freeze-Drying and Its Use in Histochemistry and Pathology
Authors: M. S. Burstone
Journal: JNCI Journal of the National Cancer Institute (1956)

A Method of Freeze-Drying and Its Use in Histochemistry and Pathology Get access M. S. Burstone M. S. Burstone National Institute of Dental Research,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 1, July 1956, Pages 49–63, https://doi.org/10.1093/jnci/17.1.49 Published: 01 July 1956 Article history Received: 24 February 1956 Published: 01 July 1956
HG-93CONCURRENT USE OF PANOBINOSTAT AND RE-IRRADIATION IN CHILDREN WITH PROGRESSIVE DIPG: REPORT OF 2 CASES
Authors: Zhihong Wang, Yubin Ge, Deniz Altinok, Janet Poulik, Sandeep Sood, Jeffrey Taub, Holly Pitman, Mark Kieran, Steven Miller
Journal: Neuro-Oncology (2016)
<emph type="ital">Composicion Universal</emph>
Authors: M. Therese Southgate
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HG-25FENRETINIDE TARGETS THE RTK-PI3K PATHWAY IN DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG)
Authors: Santosh Valvi, Maria Tsoli, Arjanna Chitranjan, Han Shen, Cecilia Chang, Anne Kankean, Anahid Ehteda, Laura Franshaw, Jie Liu, David Ziegler
Journal: Neuro-Oncology (2016)
Estimating the genetic contribution to schizophrenia
Authors: S W Matthysse, K K Kidd
Journal: American Journal of Psychiatry (1976)

The authors discuss the limitations of the concept of heritability in schizophrenia and, using reported incidence figures, assess two alternatives--the multifactorial and single major locus (SML) models. Both models predict genetic heterogeneity in schizophrenia. For some parameter values, the SML model indicates that homozygotes are rare but at very high risk. According to the multifactorial model, 9.1% of the schizophrenic population has a genetic risk of 99% or more. The authors conclude that neither model adequately accounts for the data but that predictions from both can be used to design sampling procedures which will increase the probability of selecting for study individuals whose illness is highly genetically determined.
Abstract 2506: Coronary Spasm Occurs in Coronary Artery with Diffuse Intima Thickeing without Lipd and/or Calcification:Evaluation with Intravascular Optical Coherence Tomography
Authors: Yoshinobu Morikawa, Shiro Uemura, Ken-ichi Ishigami, Tsunenari Soeda, Satoshi Okayama, Yasuhiro Takemoto, Kenji Onoue, Satoshi Somekawa, Taku Nishida, Yukiji Takeda, Hiroyuki Kawata, Manabu Horii, Tamio Nakajima, Yoshihiko Saito
Journal: Circulation (2008)

Coronary spasm (CS) plays an important role in the pathogenesis of many kinds of ischemic heart disease. However, morphological characteristics of coronary artery of CS remain unknown. We evaluated 37 patients with coronary spastic angina (CSA) who underwent diagnostic acetylcholine (ACh) provocation test, and 2 acute coronary syndrome patients suspected to have severe CS. The intravascular optical coherence tomography (OCT) was performed after complete dilatation of coronary artery in all patients and additionally performed during ACh-induced CS in 4 patients. Based on the ACh provocation test, 23 patients who developed CS and ischemic ECG changes were diagnosed as coronary spastic angina (CSA), and other 14 patients without CS were referred as CS-negative patients. CS-negative patients were further divided into 2 sub-groups according to the lipid and/or calcification content in coronary arterial wall by OCT findings. Intravascular OCT revealed most coronary segments with ACh-induced CS had homogenous intima thickening, and quantitative OCT analysis showed that CS-positive segments had significantly larger intima area compared with CS-negative segments without lipid and/or calcification (2.73±0.07 vs. 1.36±0.06 mm 2 , P&lt;0.001). By contrast, CS-positive segments had significantly smaller intima area compared with CS-negative segments with lipid and/or calcification (2.73±0.07 vs. 4.51±0.17 mm 2 , P&lt;0.001). During ACh-induced CS, lumen and total vascular area significantly decreased, whereas intima area did not change in comparison with complete vasodilatation. Furthermore, luminal surface of intimal layer formed markedly wavy configuration during CS. In CSA cases with acute coronary syndrome, we observed additional findings of intima injury as erosion and thrombus formation at spasm site. Coronary spasm occurs in coronary artery with diffuse intima thickening without lipid and/or calcification content but not in artery either without intima thickening or with lipid and/or calcification, and coronary spasm sometimes induces intimal injury by itself which may cause acute coronary event.
An Exchange
Authors: Robert P Holman
Journal: Annals of Internal Medicine (2010)

On Being a Doctor20 July 2010An ExchangeRobert P. Holman, MDRobert P. Holman, MDFrom Virginia Hospital Center, Arlington, VA 22205.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-153-2-201007200-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail It seemed like an ordinary infectious diseases consultation. I was asked to see a 48-year-old homeless man with a soft tissue infection. He was the sort of patient whose very name would produce groans among nurses and doctors. He was a bedraggled man who panhandled at the local freeway on-ramp and a familiar figure on the wards with many complications of his injection drug use.Before I could introduce myself, he called out my name. And so I did what doctors do—methodically reviewed the patient's history and uncovered things he had hidden on previous interviews. He began using heroin in ... Author, Article, and Disclosure InformationAffiliations: From Virginia Hospital Center, Arlington, VA 22205.Corresponding Author: Robert P. Holman, MD, Virginia Hospital Center, 1715 North George Mason Drive, Suite 001, Arlington, VA 22205. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 July 2010Volume 153, Issue 2Page: 130KeywordsAbscessesDrugsFemoral arteriesHeroinInfectious diseasesJugular veinMethicillin-resistant staphylococcus aureusSoft tissue infectionsStaphylococcal infectionSubstance abuse ePublished: 20 July 2010 Issue Published: 20 July 2010 Copyright & PermissionsCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Spontaneous Atheroembolism
Authors: M Bradley
Journal: New England Journal of Medicine (1995)

Figure 1. A 72-year-old man was admitted to the hospital with delirium, acute renal failure, increasing hypertension, sudden impairment of vision in the left eye, and severe pain in the left foot. Funduscopic examination of the left eye (Panel A) showed a cholesterol embolus, or Hollenhorst plaque (arrow), at the bifurcation of a retinal arteriole and vascular sheathing distal to the occlusion (arrowheads). No other physical findings were present. Distal pulses were palpable, but two toes later turned purple and one required amputation. Histologic examination of the amputated toe (Panel B) revealed an arteriole with characteristic needle-shaped clefts (arrow) resulting . . .
Brief Communication: Increased Immunogenicity of Two Lymphoma Lines After Drug Treatment of Athymic (Nude) Mice
Authors: Franca Campanile, David P. Houchens, Marilyn Gaston, Abraham Goldin, Enzo Bonmassar
Journal: JNCI Journal of the National Cancer Institute (1975)

Highly immunogenic sublines of L1210 and LSTRA lymphomas were obtained from athymic (nude) mice treated with 4(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)carboxamide (DIC) in vivo. Conventional mice, compatible with the parent tumor, rejected the DIC-treated sublines and were relatively resistant to a subsequent challenge with the parent lines. The DIC-treated sublines were not rejected by athymic mice, which indicated that the transplantation resistance to these tumors in conventional mice was thymus-cell dependent. In addition, there was marginal or no increase of tumor-cell immunogenicity when the parent lines were passaged in nude mice without DIC treatment. This indicated that the DIC-dependent immunogenic changes in DIC-treated leukemic conventional mice could not be ascribed merely to protection by naturally occurring antigenic clones that resulted from DIC-induced immunodepression.
Randomized phase 2 study: elotuzumab plus bortezomib/dexamethasone vs bortezomib/dexamethasone for relapsed/refractory MM
Authors: Andrzej Jakubowiak, Massimo Offidani, Brigitte Pégourie, Javier De La Rubia, Laurent Garderet, Kamel Laribi, Alberto Bosi, Roberto Marasca, Jacob Laubach, Ann Mohrbacher, Angelo Michele Carella, Anil K. Singhal, L. Claire Tsao, Mark Lynch, Eric Bleickardt, Ying-Ming Jou, Michael Robbins, Antonio Palumbo
Journal: Blood (2016)
The relationship of community mental health centers to the professional standards review organizations program
Authors: O B Towery
Journal: American Journal of Psychiatry (1978)

Given the realities of the professional standards review organization (PSRO) program and the necessity for accountability on the part of all health service providers, community mental health centers (CMHCs) should begin now to take an active role in planning their involvement in the PSRO program. The author points out the need for both psychiatrists and nonphysician professionals to become involved. There are many types of mental health services delivered in a given area, and the active involvement of CMHCs can be a major determinant of the shape and direction of this impact.
TCT-312 Prediction of the True Fractional Flow Reserve of Left Main Coronary Artery Stenosis with Concomitant Downstream Stenoses: in vitro and in vivo Experiments
Authors: Erika Yamamoto, Shin Watanabe, Naritatsu Saito, Yoshiaki Kawase, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2014)
Automated Analysis and Interpretation of Transrectal Ultrasonography Images in Patients with Prostatitis
Authors: J.J.M. C.H. de la Rosette, R.J.B. Giesen, A.L. Huyen, R.G. Aarnink, M.P. van Iersrl, F.M.J. Debruyne, H. Wijkstra
Journal: European Urology (1995)
QOS-29STROKES AND VASCULAR CHANGES IN IRRADIATED CHILDHOOD BRAIN TUMOR SURVIVORS
Authors: Tiina Remes, Arja Harila-Saari, Maria Suo-Palosaari, Anna Sutela, Päivi Koskenkorva, Päivi Lähteenmäki, Pekka Arikoski, Pekka Riikonen, Kirsti Sirkiä, Tuula Lönnqvist, Sanna Toiviainen-Salo, Mikko Arola, Marja Ojaniemi, Heikki Rantala
Journal: Neuro-Oncology (2016)
The VA psychiatry service as a setting for residency education
Authors: L R Faulkner, R M Rankin, J S Eaton, J H Shore, R M Atkinson
Journal: American Journal of Psychiatry (1984)

The authors report data from a survey of chairmen of academic departments of psychiatry and chiefs of Veterans Administration (VA) psychiatry services concerning administrative relationships between academic psychiatry departments and VA psychiatry services and the education of psychiatry residents in VA settings. The extent and quality of relationships, the interdependence of academic departments and VA psychiatry services, factors important for good VA training, and advantages and disadvantages of using the VA for residency education are documented. The authors present their conclusions and recommendations for improving the quality of relationships between academic departments and VA psychiatry services and for strengthening psychiatric education in the VA setting.
Rhinovirus and serum IgE are associated with acute asthma exacerbation severity in children
Authors: David B. Kantor, Nicole Stenquist, Molly C. McDonald, Blake J. Schultz, Marissa Hauptman, Craig D. Smallwood, Kyle A. Nelson, Matthew S. Perzanowski, Elizabeth C. Matsui, Wanda Phipatanakul, Joel N. Hirschhorn
Journal: Journal of Allergy and Clinical Immunology (2016)
Oral Poliovirus Vaccines
Authors: M D ADAM, R C SHERETZ
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
More is not always better: a case for low-dose leucovorin.
Authors: M M Borner, O Sartor
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.2.382 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8426218 More is not always better: a case for low-dose leucovorin. M M BornerxM M BornerSearch for articles by this author , O SartorxO SartorSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.2.382 PDF "More is not always better: a case for low-dose leucovorin.." Journal of Clinical Oncology, 11(2), pp. 382–383© 1993 by American Society of Clinical Oncology
Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes
Authors: Christoph Wanner, Silvio E. Inzucchi, John M. Lachin, David Fitchett, Maximilian von Eynatten, Michaela Mattheus, Odd Erik Johansen, Hans J. Woerle, Uli C. Broedl, Bernard Zinman
Journal: New England Journal of Medicine (2016)

Diabetes confers an increased risk of adverse cardiovascular and renal events. In the EMPA-REG OUTCOME trial, empagliflozin, a sodium-glucose cotransporter 2 inhibitor, reduced the risk of major adverse cardiovascular events in patients with type 2 diabetes at high risk for cardiovascular events. We wanted to determine the long-term renal effects of empagliflozin, an analysis that was a prespecified component of the secondary microvascular outcome of that trial.We randomly assigned patients with type 2 diabetes and an estimated glomerular filtration rate of at least 30 ml per minute per 1.73 m(2) of body-surface area to receive either empagliflozin (at a dose of 10 mg or 25 mg) or placebo once daily. Prespecified renal outcomes included incident or worsening nephropathy (progression to macroalbuminuria, doubling of the serum creatinine level, initiation of renal-replacement therapy, or death from renal disease) and incident albuminuria.Incident or worsening nephropathy occurred in 525 of 4124 patients (12.7%) in the empagliflozin group and in 388 of 2061 (18.8%) in the placebo group (hazard ratio in the empagliflozin group, 0.61; 95% confidence interval, 0.53 to 0.70; P<0.001). Doubling of the serum creatinine level occurred in 70 of 4645 patients (1.5%) in the empagliflozin group and in 60 of 2323 (2.6%) in the placebo group, a significant relative risk reduction of 44%. Renal-replacement therapy was initiated in 13 of 4687 patients (0.3%) in the empagliflozin group and in 14 of 2333 patients (0.6%) in the placebo group, representing a 55% lower relative risk in the empagliflozin group. There was no significant between-group difference in the rate of incident albuminuria. The adverse-event profile of empagliflozin in patients with impaired kidney function at baseline was similar to that reported in the overall trial population.In patients with type 2 diabetes at high cardiovascular risk, empagliflozin was associated with slower progression of kidney disease and lower rates of clinically relevant renal events than was placebo when added to standard care. (Funded by the Boehringer Ingelheim and Eli Lilly and Company Diabetes Alliance; EMPA-REG OUTCOME ClinicalTrials.gov number, NCT01131676.).
Fertility after in Utero Exposure to DES
Authors: W A Jensen, M Slajchert
Journal: New England Journal of Medicine (1980)

Since (DES) diethylstilbestrol was formerly administered in some cases of complicated pregnancy or possible miscarriage, 1 must raise the following question. In the study of Barnes et al. (March 13) or in previous studies of persons exposed to DES, was a group of patients selected because of a familial or a hereditary predisposition to the specific complications and anatomic anomalies cited? Barnes et al examined a control group composed of 155 sisters and 463 unrelated matched controls. In so many unrelated controls, any hereditary or familial tendencies toward the problems mentioned by the authors might be concealed. With this in mind, it would be interesting to repeat the study with controls consisting of siblings only. We wonder whether the results would be different.
RARE-11INTRACRANIAL ATYPICAL RHABDOID MENINGIOMA LACKING MALIGNANT FEATURES: CASE REPORT AND LITERATURE REVIEW
Authors: Mansour Mathkour, Juanita Garces, Joshua Hanna, Marcus Ware
Journal: Neuro-Oncology (2015)

RARE-11. INTRACRANIAL ATYPICAL RHABDOID MENINGIOMA LACKING MALIGNANT FEATURES: CASE REPORT AND LITERATURE REVIEW Mansour Mathkour1,2, Juanita Garces2, Joshua Hanna1, and Marcus Ware1; Ochsner Clinic Foundatino, Jefferson, LA, USA; Tulane Medical Center, New Orleans, LA, USA INTRODUCTION: Meningiomas are the most common benign intracranial tumors. They present with a number of cytological variants, most of which have no prognostic or clinical significance. One exceedingly rare variant is a meningioma with rhabdoid features, accounting for 2-3% of all meningiomas. This variant is also derived from meningoepithelial cells, however it is classified as WHO grade III owing to rapid growth, invasion of brain tissue and frequent recurrence. We describe a meningioma with rhabdoid features classified as WHO grade II as a result of uncharacteristically reduced malignant potential on cytology. To our knowledge there are three prior reported cases, two of which are intracranial of WHO Grade II meningioma with rhabdoid features. CASE: A 56-year-old male presented with abulia and slowed speech for several days. Physical exam of the patient was normal. Magnetic resonance imaging (MRI) of the brain revealed a focal heterogeneously enhancing extra-axial lesion within the left perisylvian region with mass effect on the left lateral ventricle. The patientunderwent craniotomy for tumor resection.The histological examination revealed meningioma with extensive rhabdoid features (greater than 50%). Cytology showed eccentric nuclei with abundant globoid eosinophilic cytoplasm consistent with rhabdoid features, however mitotic activity was relatively low with only 4 mitoses per 10 HPF. The patient is presently 4-months post-operation with resolution of his presenting symptoms and without evidence of recurrence. CONCLUSION: Meningiomas with rhabdoid features are known to be highly malignant with high recurrence rates, yet the tumor described by these authors exhibits reduced mitotic activity uncharacteristic of this tumor type. Based on our follow-up, there is currently no recurrence. We present a case of a rhabdoid meningioma with less aggressive features consistent with WHO II. As such, low-grade rhabdoid meningiomas should be considered as an exceedingly rare etiology, with unknown diagnostic and prognostic significance. Neuro-Oncology 17:v201–v206, 2015. doi:10.1093/neuonc/nov232.11 Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2015.
Multimedia: Patch Adams
Authors: Charles Essex
Journal: BMJ (1999)

On general release in British cinemas, Universal studios, certificate 12, 116 minutes


  If I were interviewing applicants for medical school I would pursue what they meant if they said that they wanted to help people. Patch Adams is Robin Williams’ way of saying that he wants to do just that. He has played five doctors in films since 1990, three of them in the past 12 months. Watching a good comedy and having a real belly laugh can be good, and cheap, therapy: early films of Steve Martin or Jim Carey, or Good morning, Vietnam, or reruns of Mork and Mindy with Williams’ machine gun fire quips. But Williams, who trained as a classical actor but found his forte in stand up comedy, seems to have lost the plot. Someone described him as putting the jerk into tearjerker. 




Patch Adams is based on the true story of a doctor who wants to build a hospital where the ethos is humanity and laughter. The film covers Adams’ time as a voluntary patient in a mental hospital and why he wanted to become a doctor, and his time in medical school and his challenge of the “establishment.” The characters are good, bad, or naive. Adams and the patients are good guys, of course; even the obnoxious patients are really good guys, but no one took the trouble to look beneath the surface—except Adams, that is. The bad guys are the doctors, who are so stereotyped that even the script writers of Casualty would have thought them over the top. Then there are a couple of medical students who agree with Adams but haven’t got his wisdom or courage.

This film has been very popular in the United States, perhaps reflecting a culture in which people are angry at how expensive health care is and, by association, angry with doctors. But it is hard to imagine such gross caricature finding resonance elsewhere. Although laughter underpins Adams’ therapy, this is not a comedy but a schmaltzy vehicle for Robin Williams to give impassioned speeches about humanity and caring. It is a pity Williams didn’t come and observe my colleagues for a week before embarking on this.
Antibiotic duration and timing of the switch from intravenous to oral route for bacterial infections in children: systematic review and guidelines
Authors: Brendan J McMullan, David Andresen, Christopher C Blyth, Minyon L Avent, Asha C Bowen, Philip N Britton, Julia E Clark, Celia M Cooper, Nigel Curtis, Emma Goeman, Briony Hazelton, Gabrielle M Haeusler, Ameneh Khatami, James P Newcombe, Joshua Osowicki, Pamela Palasanthiran, Mike Starr, Tony Lai, Clare Nourse, Joshua R Francis, David Isaacs, Penelope A Bryant
Journal: The Lancet Infectious Diseases (2016)