tbuckley/cabot-search huggingface dataset:
FDG Uptake by a Condylomata Acuminata in an HIV-Infected Patient Mimicked Urine Contamination
Authors: Tatsuya Wada, Kazuo Kubota, Ryogo Minamimoto, Miyako Morooka, Kanehiro Hasuo, Rie Yotsu, Hirohisa Yazaki, Shinichi Oka, Tetsuro Tujimoto, Mitsuhiko Noda
Journal: Clinical Nuclear Medicine (2012)

We report a case of a large condyloma on the upper side of the penis that exhibited a high FDG uptake on PET/CT images, mimicking urine contamination. The patient was a 30-year-old, HIV-infected homosexual man, and his CD4 cell count was 163/μL. FDG PET/CT imaging was performed for a survey of occult cancer. A whole-body FDG PET/CT examination showed an intense FDG uptake on the upper side of the penis. The CT portion confirmed that the lesion was not urine contamination but a tumor with a cauliflower-like shape. The tumor was excised and a histopathological examination revealed a condyloma.
FRI0590-HPR Evaluation of gait in children with juvenile idiopathic arthritis
Authors: N. Baydogan, E. Tarakcı, O. Kasapcopur
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Juvenile idiopathic arthritis (JIA) in children and adolescents is a chronic autoinflammatory affection which might occur in any joint. The disease causes pain that may lead to posture and movement modifications and arouses muscular imbalance with reduced range of motion in the affected joints. Clinical assessment of the gait is difficult in children, because of the complexity and rapidity of movement. In children with JIA, the gait pattern is further complicated by subtle compensatory gait alterations in response to joint pain and limb deformity. Severe disease in several joints may lead to complex gait abnormalities, which are often extremely difficult to evaluate clinically. <h3>Objectives</h3> To examine gait in children with joint involvement in knee who suffered from juvenile idiopathic arthritis (JIA) with video-based observation gait analysis. <h3>Methods</h3> 30 patients (male=9, female=21) were included in the study. Kinematic and time distance gait parameters were measured using a 10-meter walkway with separated 4 cm stripes in white and black color and a video camera. Sagittal plane views of cases (right and left, two views) and the foreground and background views of walking (two views), a total of 4 views were recorded. After observing views in the normal speed, views were observed by using slowed down frame-by-frame viewing and the stop function. Time distance parameters and motion deviations in stance phase of gait were examined. <h3>Results</h3> The mean age was 9.63±2.76 years (range 2–18 years). The mean disease duration was 4.41±2.16 years (range 1–9 years). Patient population consisted of 11 patients with romatoid factor (+) polyarticular arthritis, 4 patients with romatoid factor (-) polyarticular arthritis, 12 patients with oligoarticular arthritis, and 3 patients psoriatic arthritis subtype. Severity of motion deviations in stance phase of gait for lower extremity are represented in Table I. The mean of walking speed, step length, double step length and cadence were 0.51 m/s, 0.49±0.07 m, 0.99±0.14 m and 101±25.33 steps/min respectively. <h3>Conclusions</h3> This study reported that the time-distance variables of children with JIA were decreased according to healthy peers in the literature. In the same time, we observed some gait deviations during the stance phase in lower extremity in children with JIA. These deviations are moderate or severe increase of hip adduction, hip internal rotation and knee flexion. Also we found genu valgus and pes valgus in static posture. We have identified these problems may relate to response to pain, avoidance harm to joints and some structural changes in joints. <h3>Disclosure of Interest</h3> None Declared
Comments on ‘Prevalence of contact allergy in the general population in different European regions’ and ‘Prevalence of fragrance contact allergy in the general population of five European countries: a cross-sectional study’
Authors: B. Meding, B. Järvholm
Journal: British Journal of Dermatology (2016)

Comments on Prevalence of contact allergy in the general population in different European regions and Prevalence of fragrance contact allergy in the general population of five European countries.
SM-09 * BED-SIDE HIGH-GRADE GLIOMA PROGNOSTICATION CONCENTRIC PANEL CALCULATOR TO DETERMINE RECURSIVE PARTITIONING ANALYSIS (RPA) CLASSES
Authors: R. V. Kumar, S. Bhasker
Journal: Neuro-Oncology (2014)

AIM: Elucidation of RPA classes depends on the various combinations of PFs of HGG. Medical students frequently find it difficult to derive precise RPA classes due to presence of multitude of PFs and their distinct combination. We tried to develop a teaching tool to elucidate RPA classes based on PFs at bed-side. BACKGROUND: Recursive Partitioning Analysis (RPA) of prognostic factors (PF) in high-grade gliomas are useful in predicting survival probabilities. There are six RPA classes that are based on the presence of certain combination of PFs. Histology, age, karnofsky performance status (KPS), extent of surgery, neurological deficits and the mental status are the various PFs. Combination of the spectrum of the PFs yield exact RPA class. However, medical students find it difficult to remember / memorize these prognostic factors and RPA classes. So we decided to devise a bedside tool to derive RPA classes by combination of prevailing PFs of HGG. METHOD: We have cut the card-board circularly with progressively increasing diameters. Each concentric panel so created had a single spectrum of PFs. Some RPA classes do not depend on all the five PFs. To match these PFs to precise RPA classes, blank panel on the fourth and fifth circular card board were colored and that could be matched. We also cut a window ranging from two to six in the paracentral region at a particular distance from center on all the cards, so that they overlapped to display the exact RPA classes. RESULTS: Concentric panel with paracentral windows on the progressively increasing diameter of circular card can exactly determine the RPA classes of HGG based on the combination of existing PFs. CONCLUSIONS: Our devised concentric panel can determine the precise RPA classes after combining the PFs and can be helpful teaching tool and is first of its kind.
Idiopathic esophageal ulceration is nearly forgotten in an era of controlled human immunodeficiency virus
Authors: Noor Bekkali, Guido van den Berk, Paul Drillenburg, Dirk van Leeuwen
Journal: Endoscopy (2014)

Corrected by: Idiopathic esophageal ulceration is nearly forgotten in an era of controlled human immunodeficiency virusEndoscopy 2014; 46(S 01): E682-E682DOI: 10.1055/s-0034-1389856
Analysis of cyst fluid obtained by endoscopic ultrasound-guided fine-needle aspiration supporting the diagnosis of a pancreatic neuroendocrine neoplasm
Authors: F. Maletta, D. Pacchioni, P. Carucci, G. Accinelli, M. Bruno, F. Brizzi, P. Allegranza, M. Rizzetto, G. Bussolati, C. De Angelis
Journal: Endoscopy (2011)

A 28-year-old man presented at the emergency ward for bronchopneumonia with hemoptysis. A computed tomography (CT) scan disclosed an incidental 18-mm-wide lesion in the pancreatic tail that appeared cystic with magnetic resonance imaging, with a thick wall and a solid projection, both contrast-enhanced. Serological tumor markers were in the normal range.
Autointoxication or Intestinal Toxemia.
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Chromosomal Translocations in Patients with Mongolism and in Their Normal Relatives
Authors: W. Roy Breg, O. J. Miller, R. D. Schmickel
Journal: New England Journal of Medicine (1962)

MONGOLISM is usually the result of trisomy of a small acrocentric chromosome in Group 21–22 in the Denver Classification. This is generally referred to as 21-trisomy. These patients have a somatic chromosome number of 47.1 However, a number of cases of mongolism with a somatic chromosome number of 46 have been reported. In almost all these, karyotype analyses have revealed the probable presence of a translocation, usually between chromosomes 14 or 15 and 212 3 4 but in some cases between 21 and 22.3 , 5 In the families so far described, the translocation has been present in otherwise normal mothers as well as . . .
FRI0289 Perinatal outcomes in first and subsequent births in systemic lupus erythematousus
Authors: M. Wallenius, K. Å. Salvesen, A. K. Daltveit, J. F. Skomsvoll
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In general, pregnancy and delivery complications are more frequently observed in first pregnancy<sup>1</sup>. Most previous studies have not distinguished between first and subsequent births in analyses of pregnancy outcomes in SLE. <h3>Objectives</h3> To examine outcomes in first and subsequent births separately, in women with SLE versus references. <h3>Methods</h3> Women diagnosed with SLE according to International Classification of Diseases (ICD-10) and registered in the Medical Birth Registry of Norway (MBRN) formed the exposed group. Reference deliveries were all other deliveries 1999 – 2009 excluding mothers with any inflammatory rheumatic disease. Data for single births were stratified and analyzed in first and subsequent births. First birth was the first delivery of nulliparous women for patients and references. SGA (newborn small for gestational age) was defined as birth weight &lt; 10 percentile for expected birth weight for gestational age. Birth defects included serious malformations in any organ system according to a definition by MBRN based on ICD-10. Perinatal mortality included stillbirths (≥22 weeks of gestation) and early neonatal deaths (0-6 days in live born children). Associations between SLE and adverse perinatal outcomes were assessed in logistic regression analyses with adjustment for maternal age at delivery. <h3>Results</h3> Mean age at first delivery in SLE patients and references was 29,4 and 27,7 years, respectively (p&lt;0.001). In subsequent births mean age at delivery in SLE women was 33.0 versus 31,5 years in references (p&lt;0,001). Smoking habits were not statistically significantly different between the groups. <h3>Conclusions</h3> We observed a higher risk of low birth weight, preterm delivery, transfer to NICU, perinatal deaths and congenital malformations among the newborn of the patients. The greatest differences between groups were observed in the first pregnancy, and an increased risk of perinatal mortality among children of patients was only observed in first pregnancy. Our observations indicate that special attention should be given to first pregnancy in SLE patients. <b>References:</b> Cunningham FD, MacDonaldPC et al. Williams Obstetrics. 20 ed. Stamford, Connecticut, USA:1997 <h3>Acknowledgements</h3> The Medical Birth Registry of Norway (data delivery) The Liaison Committee between the Central Norway Regional Health Authority and NTNU (financial support) <b>Disclosure of Interest</b>: None Declared
Vaginal Prolapse Repair — Place Midurethral Sling Now or Later?
Authors: Cheryl B. Iglesia
Journal: New England Journal of Medicine (2012)

Midurethral synthetic slings have been shown to be as effective as traditional operations for the treatment of stress urinary incontinence in women and have become the standard of care for this condition.1,2 Whereas traditional procedures require tissue harvesting or an abdominal incision, midurethral synthetic slings are placed through a small vaginal incision, with the arms of the sling exiting behind the pubic bone (retropubic sling) or around the obturator foramen (transobturator sling). Unlike traditional approaches, midurethral synthetic slings are activated to kink the urethra only during times of increased intra-abdominal pressure, such as that which occurs with coughing and . . .
OC-030 Barrett’S Epithelium Shows Evidence of Gastric and Intestinal Differentiation Programmes but Preserves the Proliferative and Stem Cell Architecture of Gastric Glands
Authors: D Lavery, A Nicholson, R Jeffery, R Poulsom, H Barr, J Jankowski, M Novelli, N Shepherd, M Rodriguez-Justo, M Jansen, N A Wright, S A C Mcdonald
Journal: Gut (2013)

<h3>Introduction</h3> The origin and development of Barrett’s oesophagus has long been discussed, with three main proposals for the origin of metaplasia: from oesophageal squamous epithelium, from upward migration of cardiac glands, or from submucosal glands. <h3>Methods</h3> In Barrett’s glands we have studied the distribution of proliferative activity using Ki67 and the migration of cells in Barrett’s glands from patients infused with iododeoxyuridine 7 and 11 days pre-oesophagectomy. We have localised gene expression of mucins using immunohistochemistry (IHC) and trefoil family factor (TFF) peptides using IHC and <i>in situ</i> hybridization (ISH) and the stem cell marker Lgr5 using ISH, combining this with analysis of the clonal architecture of Barrett’s glands using mitochondrial DNA (mtDNA) as a clonal marker. <h3>Results</h3> In Barrett’s glands proliferation is seen mainly in the middle part of the gland and diminishes towards the surface and the base of the gland. Cells migrate in a bidirectional manner. MUC5AC and TFF1 expression are found superficially, while MUC6 and TFF2 are found at the bases of the glands, similar to the distribution seen in antral gastric glands: MUC2, staining goblet cells and columnar cells, is concentrated superficially. <i>Lgr5</i> mRNA is also found in the middle part of the glands, indicating the location of the stem cell niche. Barrett’s glands are clonal, indicating derivation from a single cell, and suggesting that Barrett’s stem cells have dual differentiation capacity. Gastric intestinal metaplasia, on the other hand, shows basal <i>Lgr5</i> mRNA localisation with a distribution of proliferative activity similar to intestinal crypts. <h3>Conclusion</h3> We conclude that Barrett’s glands show the proliferative and stem cell architecture, and preserve patterns of gene expression of pyloric-type gastric glands, but are maintained by unique stem cells with both gastric and intestinal differentiation capacity: we propose that Barrett’s glands originate as gastric glands and that subsequent intestinal differentiation advances with time, strongly supporting an origin from the proximal cardiac mucosa. <h3>Disclosure of Interest</h3> None Declared
Laryngeal Mask Airway in Medical Emergencies
Authors: Geoffrey Lighthall, T Kyle Harrison, Larry F Chu
Journal: New England Journal of Medicine (2014)

This video demonstrates the placement of a laryngeal mask airway, an alternative airway device that is both efficacious and easy to place. The laryngeal mask airway is routinely used for patients receiving general anesthesia and, increasingly, in patient resuscitation.
1112 Th17 CYTOKINES ENHANCE LIVER FIBROSIS VIA INCREASED SENSITIZATION OF HEPATIC STELLATE CELLS TO TGF-beta STIMULATION
Authors: T. Fabre, H. Kared, B. Willems, C. Wartelle, C. Fournier, M. Bilodeau, N.H. Shoukry
Journal: Journal of Hepatology (2013)
Abstract LB-128: High throughput screening kinase activators of Atg4B for cancer therapy.
Authors: Chih-Wen Shu, Pei-Feng Liu, John C. Reed
Journal: Cancer Research (2013)

Abstract Autophagy is an evolutionarily conserved process whereby cells catabolize damaged proteins and organelles for purposes of generating substrates for sustaining ATP production during times of nutrient deprivation. This self-eating process is associated with many diseases, particular in cancers. The theory remains controversial due to limitation of the assays about autophagy, which requires specific assays and further studies to reevaluate the role of autophagy on cancer cells. Autophagins/Atg4 are a class of cytosolic cysteine proteases and play dual roles in autophagy machinery, suggesting tightly control of Atg4 is critical for regulation of autophagy. There are four human genes encoding Atg4 (Atg4A, Atg4B, Atg4C, Atg4D). Among them, Atg4B appears functional dominance in regulation of autophagy. Knocking down Atg4B or overexpression of catalytic mutant of Atg4B inhibited cell growth in various cancer cells. Moreover, Atg4B reveals three phosphorylation sites at Ser 316, 383, 392 in cells through large-scale phosphoproteomics approach. Inhibiting phosphorylation of Atg4B diminished proteolysis activity both in vitro and in cells, suggesting kinases may serve as activators for Atg4B. Further, we employed mammalian cell-based Atg4B assay to screen potential kinases activators of Atg4B with kinome siRNA library, which consists 704 kinase related genes. Twelve hits were reproducible and reconfirmed with GFP-LC3 stably expressed cells as a secondary assay. Four kinase hits were interacted with Atg4B and showed same effect on GFP-LC3 cleavage. Knocking down kinase hits diminished Atg4B proteolysis activity and cell growth in cancer cells, demonstrating novel function of the kinase hits on Atg4B-mediated autophagy and cancer growth. Our finding may provide new kinases as biomarkers or drug targets for cancer therapy. Citation Format: Chih-Wen Shu, Pei-Feng Liu, John C. Reed. High throughput screening kinase activators of Atg4B for cancer therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-128. doi:10.1158/1538-7445.AM2013-LB-128 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Abstract 4812: Collagen regulation of Snail expression in pancreatic cancer involves TGF-β1 signaling
Authors: Mario A. Shields, Surabhi Dangi-Garimella, Seth Krantz, David J. Bentrem, Hidayatullah G. Munshi
Journal: Cancer Research (2010)

Abstract Pancreatic cancer, the fourth leading cause of cancer death in the U.S., is associated with pronounced desmoplastic reaction; however, the role of this collagen-rich fibrotic reaction in pancreatic cancer progression is poorly understood. Previously, we had shown that the collagen increased expression of the key proteinase membrane type 1-matrix metalloproteinase (MT1-MMP). Now we show that collagen can also increase expression of the zinc-finger transcription factor Snail to enhance pancreatic cancer invasion. Relative to cells grown on tissue culture plastic, PDAC cells grown in 3D collagen gels induced Snail. As we had previously published that TGF-β1 increases Snail levels, we examined the contribution of TGF-β1 signaling to collagen-induced Snail expression. Inhibiting TGF-β1 signaling with siRNA against TGF-β1 receptor type I (TbRI) or with a highly specific inhibitor of TbRI kinase activity attenuated the effect of collagen on Snail levels. To further examine the role of Snail in PDAC progression, we generated Snail-inducible PDAC cells lines. Expression of Snail in PDAC cells grown in 3D collagen gels enhanced invasion, which was blocked in the presence of the MMP inhibitor GM6001. Overexpression of Snail in PDAC cells increased MT1-MMP, while siRNA against Snail decreased MT1-MMP and also attenuated collagen-induced MT1-MMP expression. Snail expression of MT1-MMP requires ERK1/2 signaling and blocking ERK1/2 phosphorylation inhibited Snail-induced invasion in 3D collagen gels. To provide in vivo support for our findings that Snail can regulate MT1-MMP, we examined the expression of Snail and MT1-MMP in human PDAC tumors and found a statistically significant positive correlation between MT1-MMP and Snail in these tumors. Overall, our data demonstrate that collagen-rich milieu can increase the expression of Snail, and suggests that the desmoplastic reaction actively contributes to PDAC progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4812.
AB0039 Cytokine production in psoriatic arthritis depend on clinical presentation and clinical activity
Authors: E. Solau-Gervais, A. Delwail, C. Paquier, J. C. Lecron
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Psoriatic arthritis is an inflammatory with an increase of cytokine production when compared to healthy subjects but with contradictory data due to its heterogeneity and according to its activity, its clinical presentation and/or the presence of comorbidity. <h3>Objectives</h3> To study the sera and ex vivo cytokines secreted by mononuclear cells before and after stimulation of monocytes and lymphocytes through comparison of different groups of patients and according to activity, clinical presentation and comorbidity. <h3>Methods</h3> Patients with psoriatic arthritis according to the Moll and Wright criteria have been clinically evaluated by a rheumatologist and a dermatologist. Active disease was defined by either more than 3 painful and swollen joints or a BASDAI higher than 40. Inflammatory syndrome was considered to be present when the CRP exceeded 10 mg/l. Cytokines dosage (IL-1a, IL1b, IL-1Ra, TNFa, IL-6, IL-17, IFNg, IL-4 and IL-10) in the serum and after mononuclear cell (MNC) extraction was carried out with luminex before and after stimulation with LPS on the one hand and by CD3-CD28 on the other hand. <h3>Results</h3> Thirty-six patients with PsA were monitored. Mean age was 52 years and mean disease duration was 15.9 years. The sex ratio was 21 men (58.3%) and 15 women (41.7%). Thirty-four per cent had hypertension, 6% diabetes and 41% dyslipidemia; 51% were current smokers, 76% drank alcohol regularly and 27% were heavy drinkers. 72% had psoriasis on the day of the visit with a PASI (psoriasis area and severity index) averaging 5.1. Three of them had an axial form, 19 a peripheral form and 14 had both. In the serum, IFNg was increased; IL4 was decreased but not significantly while TNFa, was significantly increased in patients with psoriatic arthritis. When cytokines production of MNC in patients and healthy subjects was compared, we observed a significant increase of IL1ra (p=0,02), IL-10 (p=0,02), IL-6 (p&lt;0,0005) and TNFa (p&lt;0,001) in the absence of stimulation, an increase of IL-1a, IL1b, TNFa, IL-6 after stimulation with LPS and no significant difference after CD3-CD28 stimulation. When patients had active disease, there was no difference with regard to TNFa or IL6, whereas IL4 production was heightened after LPS stimulation. In the axial form, there was no TNFa increase compared to healthy subjects and in the peripheral form an IFNg increase and significantly heightened IL17 after CD3-CD28 stimulation were observed. No differences according to comorbidity were found. <h3>Conclusions</h3> In psoriatic arthritis, the pro-inflammatory cytokines involved are IL-1, TNF alpha and l’IL-17, while for the anti-inflammatory, cytokines involved are l’IL1RA, l’IL10 et l’IL4 with differences depending largely on clinical presentation and disease activity. <h3>Disclosure of Interest</h3> None Declared