tbuckley/cabot-search huggingface dataset:
Some Effects of Cyclophosphamide (Cytoxan) on Normal Mice and Mice With L1210 Leukemia&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Montague Lane, M.D.
Journal: JNCI Journal of the National Cancer Institute (1959)

The effects of N,N-bis-(β-chloroethyl)-N′,O-propylene phosphoric acid ester diamide, or cyclophosphamide, were evaluated in normal and leukemic mice. The overt manifestations of toxicity are described. Four days after an LD50 of cyclophosphamide, the bone marrow and spleen were aplastic. On the 6th day the marrow and spleen showed an unusual degree of megakaryocyte hyperplasia. Cyclophosphamide has been shown to be active against advanced L1210 leukemia. The effectiveness of the drug was markedly dependent upon the treatment regimen, but was independent of the route of administration. Treatment once weekly produced considerably greater increases in median survival than a daily or a 3 times weekly schedule. A regimen of treatment every 11th day was as effective in prolonging survival as a once weekly regimen, but a higher dose was required. Cyclophosphamide was much more effective than amethopterin or nitrogen mustard in prolonging the survival of mice with advanced L1210 leukemia when the optimum treatment regiment for each agent was used. The 6-mercaptopurine-resistant leukemia (L1210/AG-R) was as susceptible to the antileukemic action of cyclophosphamide as the parental L1210 strain.
FRI0542 Comparison of Two Methods of Neuropathic Pain Assessment in Carpal Tunnel Syndrome and Their Correlation with Hand Functions
Authors: E. Ceceli, S. Gümrük, M. Okumuş, S. Kocaoğlu, H. Göksu, A. Karagöz
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Carpal tunnel syndrome (CTS) is an entrapment neuropathy of the median nerve and can cause neuropathic pain and functional decrease in hand functions. <h3>Objectives</h3> The aim of this study was to compare the effectivity of Leeds assessment of neuropathic symptoms and signs scale (LANSS) with pain detect questionnaire (PDQ) in CTS and their relations with hand functions. <h3>Methods</h3> The patients were selected among the patients who admitted to physical medicine and rehabilitation outpatient clinics and the selection criteria was to have positive Tinel or Phalen sign and paresthesia in hand. 157 hands of 90 patients were evaluated by electromyography and grouped as mild, moderate or severe involvement. Neuropathic pain was analysed by LANNS and PDQ; hand functions by Duruöz hand index (DHI); sensory evaluations by Semmes Weinstein monofilaments (SWM) and grip strength by Jamar dynamometer. <h3>Results</h3> EMG findings revealed 30.4% of hands had mild, 66.5% had moderate and 2.5% had severe CTS. In statistical evaluations in order to have a homogenous group, we have chosen the moderate CTS group. LANSS scores correlated with DHI, Jamar scores (p and r values were 0.032, 0.209; 0.010, -0.250 respectively. PDQ scores correlated with VAS score, DHI, Jamar, SWM (p and r values were 0.001, 0.314; 0.000, 0.346; 0.005, -0.270; 0.000, 0.391). The correlation coefficient between LANSS and PDQ was p: 0.000; r: 0.324. <h3>Conclusions</h3> Though there is a significant correlation between LANSS and PDQ scores, PDQ scores revealed better correlation coefficients in DHI and Jamar scores and additional correlations were determined in VAS scores and SWM values.In conclusion we think PDQ presents finer results then LANNS. <h3>Disclosure of Interest</h3> None declared
Predictors of response to lithium in patients with psychoses
Authors: L W Schexnayder, J Hirschowitz, F J Sautter, D L Garver
Journal: American Journal of Psychiatry (1995)

This study sought to characterize a subset of patients with DSM-III schizophrenia or schizophreniform disorder who respond to lithium.Sixty-six psychotic patients were given a systematic therapeutic trial of lithium alone. Differences in demographic characteristics, symptoms, and family history of psychotic disorders between the responders and nonresponders to lithium were explored.Responders and nonresponders did not differ significantly in age, duration of illness, length of current episode, distribution of RDC and DSM-III diagnoses, or number of positive symptoms. However, the responders to lithium (N = 10) exhibited a paucity of negative symptoms and an absence of familial schizophrenic spectrum disorders.These preliminary results suggest the possibility of pretreatment identification of psychotic patients for whom neuroleptic medication could be avoided by therapeutic intervention with lithium alone.
Intraportal transplantation of human bone marrow mesenchymal stem cells in pigs with fulminant hepatic failure
Authors: Jun Li, Lanjuan Li
Journal: Hepatology (2012)

We are very glad to answer two questions raised by Jitraruch etal. concerning our article. Regarding the issue of "Do the authors have experimental data to show that human bone marrow mesenchymal stem cell (hBMSC)-derived hepatocytes did not trigger immune response in these animals?" Actually, we have no data concerning immune rejection, although many publications,1-4 including two references5, 6 cited by Jitraruch etal., have reported that hBMSCs have low inherent immunogenicity. hBMSC can inhibit proliferation and function of several major immune cells in vitro and in vivo. The recent report by Akiyama etal.7 demonstrated that BMSC-based immunotherapy involves coupling via Fas/Fas ligand (FasL) to induce T cell apoptosis. Regarding the second question, the possible reason is that the D-galactosamine induced fulminant hepatic failure animals died within a very short time (within 96 hours). Furthermore, there must be many differences between clinical patients and animal models. Following are the original conclusions and abstract in references cited by Jitraruch etal. These two references all indicated that BMSC has the characteristic of immune tolerance. The conclusion from the first reference is, "Undifferentiated and differentiated MSC do not elicit alloreactive lymphocyte proliferative responses and modulate immune responses. The findings support that MSC can be transplantable between HLA-incompatible individuals."5 The abstract of the second reference mentions, "In vitro data suggest that MSCs have low inherent immunogenicity as they induce little, if any, proliferation of allogeneic lymphocytes. Instead, MSCs appear to be immunosuppressive in vitro. They inhibit T-cell proliferation to alloantigens and mitogens and prevent the development of cytotoxic T-cells. In vivo, MSCs prolong skin allograft survival and have several immunomodulatory effects, which are presented and discussed in the present study. Possible clinical applications include therapy-resistant severe acute graft-versus-host disease, tissue repair, treatment of rejection of organ allografts and autoimmune disorders."6 Jun Li M.D., Ph.D.*, Lanjuan Li M.D.*, * State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Histopathologic Studies of Peritoneal Implantation and Lung Metastasis at Different Stages of the Gradual Transformation of the MC1M Mouse Sarcoma into Ascites Form&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: N RINGERTZ, E KLEIN, G KLEIN
Journal: JNCI Journal of the National Cancer Institute (1957)
Tympanoplasty in Children
Authors: G D Smyth, T H Hassard
Journal: JAMA (1963)

To evaluate the possibility that current teaching regarding the postponement of tympanoplasty as desirable in young patients might be less correct than previously thought, the results in 260 ears in patients aged less than 16 years were scrutinized. It was found that not only were the functional results comparable to those obtained with adult patients, but also that there was little evidence of subsequent deterioration of initially good hearing results with time. The findings in regard to postoperative cholesteatomatous complications were in agreement with those previously reported and were not different from those in adult patients. It is concluded that, with children, in the interests of health, educational progress and social integration, tympanoplasty procedures, often in two stages, should be carried out as soon as concomitant upper respiratory disease is brought under control. Childhood cholesteatoma is not a "different" disease. Functional results are the same as with adults and are influenced by identical deficiencies in our technical ability.
Response of Patients with Advanced Neoplasms to the Intravenous Administration of &lt;italic&gt;Alpha&lt;/italic&gt;-Peltatin&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: E M GREENSPAN, J COLSKY, E B SCHOENBACH, M J SHEAR
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Response of Patients with Advanced Neoplasms to the Intravenous Administration of Alpha-Peltatin Get access Ezra M. Greenspan, Ezra M. Greenspan Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacob Colsky, Jacob Colsky Search for other works by this author on: Oxford Academic PubMed Google Scholar Emanuel B. Schoenbach, Emanuel B. Schoenbach Search for other works by this author on: Oxford Academic PubMed Google Scholar Murray J. Shear Murray J. Shear Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 6, June 1954, Pages 1257–1275, https://doi.org/10.1093/jnci/14.6.1257 Published: 01 June 1954 Article history Received: 07 December 1953 Published: 01 June 1954
Psychodynamics and the Allergic Patient
Authors: H A ABRAMSON
Journal: JAMA (1949)

Taken as a whole, the book is useful in collecting this author's many contributions to the literature of squint, since nearly all of these are original in their point of view and many of them extremely valuable. While the reviewer would not advocate this book as a text for the student beginning his training, the experienced worker would find it worth while to review the whole subject of squint, using this book to obtain an entirely different point of view. Francis Heed Adler.
The Inhibitory Action of <italic>p</italic>-Hydroxypropiophenone on Hepatic Carcinoma Induced by Azo Dye
Authors: C H ROBERTSON, A C GRIFFIN, H L RICHARDSON
Journal: JNCI Journal of the National Cancer Institute (1954)

The Inhibitory Action of p-Hydroxypropiophenone on Hepatic Carcinoma Induced by Azo Dye Get access Charles H. Robertson, Charles H. Robertson Search for other works by this author on: Oxford Academic PubMed Google Scholar A. Clark Griffin, A. Clark Griffin Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard L. Richardson Howard L. Richardson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 519–527, https://doi.org/10.1093/jnci/15.3.519 Published: 01 December 1954 Article history Received: 23 July 1954 Published: 01 December 1954
THU0537 Selected Factors of Complement Lectin Pathway Factors in Polish Children with Juvenile Idiopathic Arthriti
Authors: Z. Zuber, K. Kasperkiewicz, M. Michalski, Ł. Eppa, M. Bartłomiejczyk, A. Świerzko, E. Mężyk, M. Noszczyńska, M. Cedzyński
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile idiopatic arthritis (JIA) is the most common childhood rheumatic disease. Complement system is suggested to contribute to JIA. Mannose-binding lectin (MBL) and ficolin -3 are important factors of innate immunity with ability to initiate the lectin pathway of complement, thanks to co-operation with MASP proteases. Although they are produced in the liver and circulates in the blood, they are also detected extravasculary. They contribute to the clearance of microorganisms as well as apoptotic cells. The mutations in the MBL2 exon 1 and promoter region (designed as O/O+LX/O) as well as <i>FCN3</i> frame-shift mutation 1637 delC influence significantly proteins9 serum level. <h3>Objectives</h3> The aim of this study was to evaluate the contribution of the complement lectin pathway system to the pathogenesis of juvenile idiopathic arthritis. <h3>Methods</h3> Serum and/or DNA samples were collected from 175 patients with JIA and 98 healthy controls from the St Louis Children9s Hospital, Krakow, Poland. Additionally, 55 samples of synovial fluid were obtained. The concentrations and activity of MBL and ficolin-3 were determined in functional ELISA with use of specific antibodies [1, 2]. The single nucleotide polymorphisms in <i>MBL2</i> gene promoter and exon 1 as well as <i>FCN3</i> frame-shift mutation 1637 delC were determined using PCR/RFLP methods [1, 2]. <h3>Results</h3> The mean age of JIA patients and healthy controls was 12 and 9 years, respectively (p=0,01). The serum levels of MBL and ficolin-3 in JIA patients did not differ from levels in the control group. The <i>MBL2</i> gene polymorphism was analysed in 112 JIA patients and 98 healthy controls. The frequency MBL deficiency-associated genotypes (so called O/O+LXA/O) was 17,8% and 16,3%, respectively. Additionally, no differences in the frequency of <i>FCN3</i> 1637delC mutation was noticed (5 and 5,6%, respectively). Concentrations of both MBL and ficolin-3 correlated with CRP levels in patients group (p=0,02). No difference in MBL level in JIA patients and controls representing MBL2 AA genotype were found. Although MBL and ficolin-3 levels did not differ between the groups, the activity of MBL-MASP-2 complexes was significantly higher in JIA patients than in controls (p=0,002). MBL, its active complex with MASPs and ficolin-3 were also detected in synovial fluid samples from JIA patients and their levels correlated significantly with those in sera (p&lt;0,0001). <h3>Conclusions</h3> The presence of factors of lectin pathway in synovial fluid may suggest their contribution to development of juvenile idiopatic arthritis. <h3>Disclosure of Interest</h3> None declared
PTH-010 Uk training in therapeutic endoscopy – are we achieving the basics? results of the bsg national training survey
Authors: PJ Basford, S Samji
Journal: Gut (2015)

<h3>Introduction</h3> Colonoscopic polypectomy and endoscopic treatment of acute upper gastrointestinal bleeding (AUGIB) are key skills for the majority of consultant gastroenterologists. Competence in polypectomy is assessed by direct observation of polypectomy skills (DOPyS) with 4 competent level 2 (&gt;1 cm) polypectomies required for full colonoscopy certification. Measures for defining competence in endoscopic treatment of AUGIB are in development. There is evidence of slow rates of progression to achieve basic endoscopic skills amongst gastroenterology trainees due to other service and training pressures.<sup>1</sup> <h3>Method</h3> The BSG national training survey was open to all UK gastroenterology trainees from June–August 2014. Data on exposure to polypectomy and endoscopic treatment of AUGIB was analysed as well as trainees desire to train in advanced endoscopic techniques. <h3>Results</h3> 32.6% (263/806) of UK trainees completed the survey. 68% of ST6 (year 4) trainees and 38% of final year trainees have performed &lt;10 level 2 polypectomies without physical assistance. 10% of ST6 trainees and 7% of final year trainees have performed fewer than 10 level 1 polypectomies. 52% of trainees in their final 2 years (<i>senior trainees</i>) wish to formally train in endoscopic mucosal resection (EMR), with corresponding figures of 40% for ERCP, 29% for EUS, and 33% for enteroscopy. 28% of senior trainees report having the opportunity to perform endoscopy in a patient with AUGIB either monthly or less often (less than once per month/never). &gt;95% of senior trainees feel they will be competent to perform variceal and non-variceal AUGIB endoscopic treatment as a newly qualified consultant. 91% feel they will be competent to place a Sengstaken-Blakemore tube if required. <h3>Conclusion</h3> Exposure to level 2 polypectomy amongst senior gastroenterology trainees is limited, which may explain slow rates of progression to full colonoscopy certification.<sup>1</sup>Over a quarter of senior trainees have limited opportunity to perform endoscopy in cases of AUGIB. Virtually all trainees feel they will be competent in the endoscopic management of AUGIB as a new consultant, but the documented lack of exposure for some trainees suggests this may not be the case. Despite slow progression to basic endoscopy competencies, large numbers of trainees wish to train in advanced endoscopic techniques. These results suggest the need for focused training lists to develop key therapeutic endoscopic skills such as removal of level 2 polyps, and systems to guarantee dedicated supervised exposure to AUGIB cases. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Neale JR, Basford PJ. General medical training in gastroenterology: views from specialist trainees on the challenges of dual accreditation. Clin Med. 2015;15(1):35–9
The Sex-Linked Histocompatibility Antigens
Authors: L SACHS, E HELLER
Journal: JNCI Journal of the National Cancer Institute (1958)

Sex-linked histocompatibility antigens were studied in 6 strains of mice.  Fitted pinch skin grafts taken from the dorsal or lateral side of the body were made in such a way that hair growth on the graft would be in a direction opposite to that of the recipient.  2nd-set grafts were made 42-80 days after the 1st graft.  To determine the immunizing effects of various tissues the spleen lymph nodes and liver were inoculated intraperitoneally from males to females.  The production of the H-2 antibody was examined in females immunized with male tissue using the dextran-human serum method.  Male-to -female skin grafts were rejected 100% in all 6 strains of mice tested whereas skin grafts involving other sex combinations were successful.  Male-to-female grafts were rejected even after the growth of new hair.  The immunological nature of the graft rejection was confirmed by the existence of a 2nd-set response in all the strains.  The presence of sex-linked histoco mpatibility antigens seemed to be a general phenomenon.  In addition to skin the antigens were present in other tissues such as liver and spleen.  Sex-linked antigens in relation to the H-2 system seem to be weaker antigens like H-3 and H-1 do not elicit the production of detectable hemagglutinins and do not appear to elicit the type of cytot oxic antibodies that are detected by the  addition of complement.  It is suggested that the antigenic differences between male and female tissues could be used to separate sperm carrying the X from the sperm carrying the Y chromosome.
Stereotactic Surgery in Parkinson's Disease
Authors: G Linazasoro, J Guridi, L Vela, A Gorospe, M C Rodríguez, M Aguilar, E Ramos, E Tolosa, J A Obeso
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Targeted Therapy Blocks Growth of Triple-Negative Breast Cancer in Mice
Authors: Tracy Hampton
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal