tbuckley/cabot-search huggingface dataset:
Abstract 2573: Investigation of factors involved in the hypersensitivity to KP1339-treatment
Authors: Beatrix Alte, Christine Pirker, Thomas Mohr, Kushtrim Kryeziu, Bernhard K. Keppler, Petra Heffeter, Walter Berger
Journal: Cancer Research (2015)

Abstract The ruthenium-based compound KP1339 (trans-(tetrachlorobis(1H-indazole)ruthenate(III)), which is currently in Phase I/II trial, is already known for its promising anticancer activity. In course of a recent screening using diverse cancer cell lines of different origin (n = 25), a small subgroup with exceptional sensitivity to KP1339-treatment was discovered. The aim of the here presented study was to identify factors that underlie this sensitivity or which are connected to resistance to KP1339. Due to the fact that KP1339 comprises a metal center, interpretations of it's mode of action tend towards either generation of ROS or DNA binding. To avoid a biased approach, whole genome expression arrays were performed with mRNA isolated from hypersensitive and normal responsive cells that were either untreated or treated with KP1339 for 3 h and 6 h. Subsequent bioinformatic analysis of the gained data indicated that while hypersensitive cell lines activated pathways indicative for response to chemical stimuli (“metal ion”, “organic compound”), in normal responsive ones preferentially genes involved in pathways controlling cell cycle, DNA repair and metabolism were found. Subsequent investigations confirmed that upon KP1339-treatment hypersensitive cell lines showed pronounced apoptosis induction (indicated by caspase-mediated PARP cleavage and appearance of apoptotic nuclei visualized by DAPI staining). In contrast, normal responsive cells rather reacted with prolonged duration of the G2 phase to KP1339 treatment (video evaluation). This was confirmed by FACS analysis of ethanol-fixed and propidium iodide-stained cells indicating a profound increase in the percentage of cells with double DNA content upon KP1339 treatment. Moreover, in accordance to previous studies, KP1339 induced strong phosphorylation of ERK, p38 and JNK especially in normal responsive cell lines. This is of interest as p38 and JNK activation are known to be pro-survival factors within the extrinsic pathway of apoptosis. The relevance of this particular pathway is supported by preliminary results of activation of caspase 8 upon KP1339 treatment in hypersensitive cells. This knowledge can help to better understand the mechanisms underlying the promising anticancer activity of KP1339. Citation Format: Beatrix Alte, Christine Pirker, Thomas Mohr, Kushtrim Kryeziu, Bernhard K. Keppler, Petra Heffeter, Walter Berger. Investigation of factors involved in the hypersensitivity to KP1339-treatment. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2573. doi:10.1158/1538-7445.AM2015-2573
Leonhart Fuchs (1501–1566)
Authors: Heinrich G. Brugsch
Journal: New England Journal of Medicine (1961)

THE memory of Leonhart Fuchs has been kept fresh by the thoughtfulness of a botanist, Charles Plumier, who named the lovely fuchsia for the once famous physician in grateful recognition of his beautiful herbal published in 1542. De historia stirpium is a botanical masterpiece. This sumptuous folio was printed by Michael Isingrin at Basel, and contains more than 500 wood-block illustrations of native (German) and foreign plants considered in the midsixteenth century of use to medicine. Among them are the earliest European drawings of certain American plants, including the pumpkin gourd and Indian corn. The pictures, drawn from fresh specimens, . . .
Half of wealthy and 98% of poorer cities breach air quality guidelines
Authors: Matthew Limb
Journal: BMJ (2016)

More than 80% of people living in urban areas where air pollution is monitored are exposed to harmful air quality levels, the World Health Organization has warned.

WHO said that new findings from its urban ambient air pollution database, published on 12 May, showed that global urban air pollution levels increased by 8% from 2008 to 2013, despite improvements in some regions.1

Poorer areas had worse results—98% of cities in low and middle income countries with more than 100 000 inhabitants did not meet WHO air quality guidelines compared with 56% in high income countries.

Maria Neira, WHO director for public health and the environment, said, “Urban air pollution continues to rise at an alarming rate, wreaking havoc on human health.” But the agency said that awareness of the issue was rising as more cities were monitoring their air quality. The …
Effects of all- retinoic acid on orphan receptor APJ signaling in spontaneously hypertensive rats
Authors: J ZHONG, D HUANG, G LIU, H JIN, Y YANG, Y LI, X SONG, K DU
Journal: Cardiovascular Research (2004)

Objective: Studies show general agreement that all-trans retinoic acid (atRA) has been linked to the regulation of G protein-coupled receptor (GPCRs) signaling. To further validate effects of atRA on the cardiovascular GPCRs, the present study was designed to assess whether atRA will modulate orphan receptor APJ, a homologue of angiotensin II type 1 (AT1) receptor.
P0364 : Clinic evaluation of circulating micrornas as potential biomarkers of hepatocellular carcinoma in patients with HBV chronic infection
Authors: G.P. Caviglia, M.L. Abate, E. Petrini, S. Gaia, P. Manzini, P. Carucci, M. Rizzetto, A. Smedile
Journal: Journal of Hepatology (2015)
Abstract 3987: Exosomal microRNA in cell-free urine samples as a source for liquid prostate cancer biopsy
Authors: Thorarinn Blondal, Anni R. Thomsen, Jörg Krummheuer, Michael Borre, Jacob Fredsøe, Christa Haldrup, Ditte Andreasen, Maria W. Teilum, Niels Tolstrup, Karina D. Sørensen, Torben F. Ørntoft, Peter Mouritzen
Journal: Cancer Research (2015)

Abstract MicroRNAs constitute a class of small cellular RNAs (typically 19-23 nt) that function as post-transcriptional regulators of gene expression. Current estimates indicate that more than one third of the human cellular transcriptome is regulated by this small class of RNA (∼2000 miRNA). MicroRNAs have been shown to be actively exported from tissues into the circulation through a variety of mechanisms including complexing with RNA binding proteins or HDL and through active exosome transport. Exosomes are nanovesicles secreted into the extracellular environment by a wide range of cell types under normal and pathological conditions. As the profile of exosomal microRNAs may be a fingerprint of the releasing cell type and because they are released in easily accessible body fluids such as blood and urine, their microRNA content holds potential as biomarkers for early detection of malignancy. Cell free urine samples are an obvious liquid biopsy source for microRNA markers in prostate cancer and could serve as diagnostic tools as well as treatment response markers. Yet microRNA levels in urine samples are extremely sparse and cannot be detected reliable by conventional sample preparation methods. It has been reported that tumour derived exosomes carrying genetic information specific for prostate cancer can be measured in urine samples following prostate massage. However, a methodology eliminating the need for prostate massage of every patient to be tested in a clinical setting is highly desirable. The purpose of this study was to combine a simple exosomal enrichment method with our highly sensitive LNA™-based qPCR platform for detection of microRNAs and apply this to a cohort consisting of more than 300 cell free urine samples from prostate cancer cases and controls. In conclusion, cell free urine samples holds potential as a liquid biopsy source for exosomal microRNA markers in prostate cancer, showing miRNA signatures of strong diagnostic potential. Analysis is pending and data will be presented. Citation Format: Thorarinn Blondal, Anni R. Thomsen, Jörg Krummheuer, Michael Borre, Jacob Fredsøe, Christa Haldrup, Ditte Andreasen, Maria W. Teilum, Niels Tolstrup, Karina D. Sørensen, Torben F. Ørntoft, Peter Mouritzen. Exosomal microRNA in cell-free urine samples as a source for liquid prostate cancer biopsy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3987. doi:10.1158/1538-7445.AM2015-3987
The spectrum effect in tests for risk prediction, screening, and diagnosis
Authors: Juliet A Usher-Smith, Stephen J Sharp,, Simon J Griffin
Journal: BMJ (2016)

The spectrum effect describes the variation between settings in performance of tests used to predict, screen for, and diagnose disease. In particular, the predictive use of a test may be different when it is applied in a general population rather than in the study sample in which it was first developed. This article discusses the impact of the spectrum effect on measures of test performance, and its implications for the development, evaluation, application, and implementation of such tests.
Prognostic Value of Programmed Death Ligand 1 and Programmed Death 1 Expression in Thymic Carcinoma
Authors: Shintaro Yokoyama, Hiroaki Miyoshi, Kazutaka Nakashima, Joji Shimono, Toshihiro Hashiguchi, Masahiro Mitsuoka, Shinzo Takamori, Yoshito Akagi, Koichi Ohshima
Journal: Clinical Cancer Research (2016)

The immune checkpoint of the programmed death 1/programmed death ligand 1 (PD-1/PD-L1) pathway is believed to play an important role in evasion of host antitumor immune surveillance in various malignancies; however, little is known about its role in thymic carcinoma. This study investigated PD-1/PD-L1 expression and its association with clinicopathologic features, the expression of immune-related proteins in tumor-infiltrating lymphocytes (TIL), and patient prognosis.PD-L1 and PD-1 expression was evaluated by IHC in 25 thymic carcinoma tissue specimens. Copy number alterations of the PD-L1 gene in 11 cases were assessed in formalin-fixed, paraffin-embedded material using qRT-PCR.Compared with normal subjects, 3 thymic carcinoma patients showed an increase in PD-L1 copy number, whereas 8 did not. PD-L1 was significantly overexpressed in cases with copy number gain as compared with normal cases. High PD-L1 expression was associated with higher disease-free and overall survival rates as compared to cases with low expression. Prognostic analysis revealed low PD-L1 expression and high number of PD-1(+) TILs as significant predictors of poor survival, together with Masaoka-Koga stage IVa/IVb disease and incomplete resection. In the quantitative analysis of TILs, PD-L1 expression correlated proportionally with the number of infiltrating CTLs.Here, for the first time, we report that PD-L1 and PD-1 expression might be useful prognostic predictors in thymic carcinoma. Further studies are expected to substantiate the prognostic value of PD-L1 and PD-1 expression, and the potential efficacy of targeting the PD-1/PD-L1 pathway in thymic carcinoma via immunotherapy. Clin Cancer Res; 22(18); 4727-34. ©2016 AACR.
Striking Predictive Power For Relapse and Decreased Survival Associated With Detectable Minimal Residual Disease by IGH VDJ Deep Sequencing Of Bone Marrow Pre- and Post-Allogeneic Transplant In Children With B-Lineage ALL: A Subanalysis Of The COG ASCT0431/PBMTC ONC051 Study
Authors: Michael A. Pulsipher, Christopher S Carlson, Krailo Mark, Donna A. Wall, Kirk R. Schultz, Nancy Bunin, Michael Kalos, Desmarias Cindy, David Williamson, Gastier-Foster Julie, Michael J. Borowitz, Stephan A. Grupp
Journal: Blood (2013)
Case 11-1969
Authors: John D. Stoeckle, Benjamin Castleman
Journal: New England Journal of Medicine (1969)

Presentation of CaseA seventy-year-old man was admitted to the hospital because of weakness and a cough.Thirty years previously, because of pulmonary tuberculosis, he spent three years in a sanatorium. Twenty years before entry a pneumothorax was performed. Isoniazid therapy was begun five years later and continued for eight years. During the five years before entry he remained in a nursing home, where he took no medication. During the year before admission he lost 15 pounds in weight. Three weeks before entry a cough productive of small amounts of sputum developed, without hemoptysis or pleurisy. The urinary output decreased, . . .
The Antiphospholipid Syndrome
Authors: Jacob H. Rand
Journal: Annual Review of Medicine (2003)

The antiphospholipid (aPL) antibody syndrome is an autoimmune condition in which vascular thrombosis and/or recurrent pregnancy losses occur in patients with laboratory evidence for antibodies that bind to phospholipids. There have been significant advances in the recognition of the role of phospholipid-binding cofactors, primarily β 2 GPI, as the true immunologic targets of the antibodies. Recent evidence suggests that the antibodies disrupt phospholipid-dependent anticoagulant mechanisms and/or that aPL antibodies induce the expression of procoagulant and proadhesive molecules on endothelial cells. Current diagnosis is based on clinical findings and empirically derived tests, such as assays for antibodies that bind to phospholipids or putative cofactors and coagulation assays that detect inhibition of phospholipid-dependent coagulation reactions. Current treatment relies primarily on anticoagulant therapy. Research advances are expected to bring mechanistically based diagnostic tests and improved therapy that target the roots of the disease process.
Commentary: Promiscuity is acceptable only for men
Authors: D. Bhugra
Journal: BMJ (1998)

We reject any suggestion that this operation is analogous to traditional clitoridectomy.There are strong arguments for rejecting a request for clitoridectomy, but equally strong ones exist for accepting hymen reconstruction.4][5][6][7] Hymen reconstruction, like male circumcision, is an example of "ritualistic surgery."Our definition of ritualistic surgery, modified from that of Bolande, 8 9 is "fulfilment of a person's need rather than a response to their medical condition."The ethics of hymen reconstruction could be compared to the ethics of cosmetic surgery, an accepted part of plastic and reconstructive surgery worldwide.
Current and Future Therapies for Hepatitis C Virus Infection
Authors: Resat Ozaras, Mücahit Yemisen, İlker İ Balkan
Journal: New England Journal of Medicine (2013)

In their review of drug therapy for chronic hepatitis C infection, Liang and Ghany (May 16 issue) 1 summarize boceprevir-and telaprevir-based regimens.Figure 2 of the article describes the regimens according to the response to the previous therapy, the responseguided therapy, and the stopping rules.The boceprevir regimen they describe represents the labeling information in the United States. 2 However, the information about boceprevir in European regimens has some differences 3 -the duration of therapy for patients who have not had a response to previous therapy (whether the patient had a relapse, a partial response, or no response) is 48 weeks (peginterferon alfa and ribavirin for 4 weeks, then all three drugs through week 36, and then peginterferon alfa and ribavirin through week 48).For the readers of the Journal in Europe, our comments might be useful.
Patients and Physicians Beliefs and Practices Regarding Adherence to Cardiovascular Medication
Authors: Rosemary Hines, Neil J. Stone
Journal: JAMA Cardiology (2016)

Nonadherence to medication is a salient cause of poor outcomes of health care and a primary driver of growing health care costs. Little is known about physician communication with patients regarding their adherence to cardioprotective medication.To identify patients' and physicians' beliefs and practices regarding discussions of adherence to cardioprotective medication.Paired patient and physician questionnaires were developed based on the 8-item Morisky Medication Adherence Scale and administered to 2 academic and 2 community-based cardiology practices in the Chicago, Illinois, metropolitan and suburban areas from June 2 to July 22, 2015. Twenty-one cardiologists and 66 of their outpatients 18 years and older participated.Patient and physician beliefs about discussions of adherence to medication, the frequency of such discussions, and physician recognition of patients who are nonadherent to medication.A total of 21 physicians (5 [24%] women) and 66 patients (23 [35%] women; mean age, 71.6 years) participated in the study. Forty (61%) patients reported rarely or never discussing their adherence to medication with their physicians. Of these patients, 8 (13%) had poor adherence and 36 (55%) had moderate adherence. Only 1 of the physicians of the patients with the poorest adherence correctly identified a patient as being poorly adherent. Fourteen physicians (67%) disagreed with the statement, "I am aware of how often my patient misses a dose of medication." By contrast, all of the physicians agreed that it is important for them to discuss adherence to medication with their patients.Physicians acknowledge the importance of discussing adherence to medication with their patients, yet for many reasons these discussions are uncommon. More important, our study found a notable failure by cardiologists to correctly recognize which of their patients were nonadherent. The novel design of our research identified an important yet neglected aspect of clinical practice. We recommend that physicians include a highly specific question about adherence to medication at every patient visit.
Case 20-1975
Authors: Irwin M. Freedberg, James J. Galdabini
Journal: New England Journal of Medicine (1975)

Presentation of CaseA 40-year-old man was admitted to the hospital because of dermatitis and weight loss.He was well until two years previously, when he began to limit his caloric intake to lose weight. After losing the desired 10 kg he resumed his usual dietary habits, but weight loss continued. Seven months before admission a rash developed over the face and intertriginous areas; the tongue was tender, and occasional painful oral erosions developed. Five months before entry a physician found hepatic enlargement, normocytic anemia and abnormal results of a glucose tolerance test. Additional tests, including x-ray studies of the . . .
Molecular Characterization of the t(8; 13)(p11;q12) Translocation Associated With an Atypical Myeloproliferative Disorder: Evidence for Three Discrete Loci Involved in Myeloid Leukemias on 8p11
Authors: Ivan H. Still, Olga Chernova, David Hurd, Richard M. Stone, John K. Cowell
Journal: Blood (1997)
Comparison of Some Biological Effects of Sterigmatocystin and Aflatoxin Analogues on Primary Cell Cultures
Authors: Johanna C. Engelbrecht, B. Altenkirk
Journal: JNCI Journal of the National Cancer Institute (1972)

The toxicity of 15 analogous compounds, related to either sterigmatocystin or aflatoxin B1, was evaluated on a primary cell culture system. In addition, the effects of these compounds on nucleolar morphology, mitosis, and incorporation of 3H-thymidine and 3H-uridine were studied. Structurally, these compounds were divided into 3 groups manifesting distinct toxic patterns which indicated a correlation between toxicity and structure. Apparently an unsaturated Δ1,2-furobenzofuran system and the position of methoxy and hydroxy groups on the xanthone ring of the sterigmatocystin analogues affected the cytotoxicity in these cell cultures.
Sustained Alterations In Bone Marrow Stromal Cells From Patients With Myeloproliferative Neoplasms (MPN) Contribute To Remodelling Of The Bone Marrow Microenvironment Prior To The Manifestation Of Myelofibrosis
Authors: Rebekka K. Schneider, Isabelle Leisten, Susanne Ziegler, Anne Schumacher, Björn Rath, Dirk Fahrenkamp, Gerhard Mueller-Newen, Martina Crysandt, Stefan Wilop, Edgar Jost, Ruth Knuechel, Tim H. Bruemmendorf, Patrick Ziegler
Journal: Blood (2013)
Selinexor (Kpt-330), an Oral, Selective Inhibitor of Nuclear Export (Sine) Shows Anti-Prostate Cancer (Prca) Activity Preclinically & Disease Control in Patients (Pts) with Chemotherapy Refractory, Castrate-Resistant Prostate Cancer (Crpc)
Authors: H. Mahaseth, S.N. Maity, N.Y. Gabrail, A. Mahipal, J.F. Gericitano, S. Shacham, T. Rashal, B. Klebanov, R. Carlson, E. Shacham, D. Vincent, M. Kauffman, A.F. Shields, M.R. Mirza, J.C. Araujo
Journal: Annals of Oncology (2014)
Treatment of Renal Cell Cancer With Programmed Cell Death 1 Blockade
Authors: Kim Margolin
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Man with disabilities born from incestuous rape has right to compensation, rules judge
Authors: Clare Dyer
Journal: BMJ (2016)

A 29 year old man who was born with serious disabilities after an incestuous rape has won the right to criminal injuries compensation, in the first case of its kind in the United Kingdom.

The man, referred to as Y, has severe learning difficulties, developmental delay, a heart murmur, hearing and sight problems, lax joints, epilepsy, and no sense of danger. He was born as a result of his mother’s rape by her own father, who was later convicted of incest.

Y’s mother has already received compensation from the Criminal Injuries Compensation Authority, the state funded body that compensates victims of violent crime in England, Scotland, and Wales. But when Y’s …
A mono institutional retrospective analysis on the safety and efficacy of first-line Folfiri or Folfox (CT) plus bevacizumab (B) in young and elderly patients with metastatic colorectal cancer (MCC)
Authors: M.G. Chilelli, C. Signorelli, A. Fabbri, L. Moscetti, G. D'Auria, F. Nelli, D. Padalino, F. Primi, I. Sperduti, C. Blandino, E.M. Ruggeri
Journal: Annals of Oncology (2015)