tbuckley/cabot-search huggingface dataset:
THE NORTH BRITISH DERMATOLOGICAL SOCIETY
Authors: M S SMITH
Journal: British Journal of Dermatology (1952)

British Journal of DermatologyVolume 64, Issue 7-8 p. 299-308 THE NORTH BRITISH DERMATOLOGICAL SOCIETY First published: July 1952 https://doi.org/10.1111/j.1365-2133.1952.tb15809.xCitations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume64, Issue7-8July 1952Pages 299-308 RelatedInformation
Liquid Biopsy Detection of Kras and Braf Mutations May Be Useful As a Prognostic or Predictive Marker
Authors: T. Yamada, H. Kan, S. Matsumoto, M. Koizumi, A. Matsuda, S. Shinji, Y. Yokoyama, A. Yamagishi, T. Iwai, S. Kitano, M. Nakayama, A. Watanabe, E. Uchida
Journal: Annals of Oncology (2014)
The inherence heuristic: An intuitive means of making sense of the world, and a potential precursor to psychological essentialism
Authors: Andrei Cimpian, Erika Salomon
Journal: Behavioral and Brain Sciences (2014)

Abstract We propose that human reasoning relies on an inherence heuristic , an implicit cognitive process that leads people to explain observed patterns (e.g., girls wear pink) predominantly in terms of the inherent features of their constituents (e.g., pink is a delicate color). We then demonstrate how this proposed heuristic can provide a unified account for a broad set of findings spanning areas of research that might at first appear unrelated (e.g., system justification, nominal realism, is–ought errors in moral reasoning). By revealing the deep commonalities among the diverse phenomena that fall under its scope, our account is able to generate new insights into these phenomena, as well as new empirical predictions. A second main goal of this article, aside from introducing the inherence heuristic, is to articulate the proposal that the heuristic serves as a foundation for the development of psychological essentialism. More specifically, we propose that essentialism – which is the common belief that natural and social categories are underlain by hidden, causally powerful essences – emerges over the first few years of life as an elaboration of the earlier, and more open-ended, intuitions supplied by the inherence heuristic. In the final part of the report, we distinguish our proposal from competing accounts (e.g., Strevens's K-laws) and clarify the relationship between the inherence heuristic and related cognitive tendencies (e.g., the correspondence bias). In sum, this article illuminates a basic cognitive process that emerges early in life and is likely to have profound effects on many aspects of human psychology.
PWE-173 Investigation of volatile organic compounds emitted from faeces for the diagnosis of giardiasis
Authors: A Bond, A Vernon, S Reade, A Mayor, J Wastling, C Minetti, K Lamden, C Probert
Journal: Gut (2015)

<h3>Introduction</h3> Giardiasis is a common but neglected intestinal infection worldwide, caused by the flagellated intestinal protozoan<i>Giardia duodenalis</i>(syn. <i>lamblia/intestinalis</i>). Several methods are available for the laboratory diagnosis of <i>Giardia</i>. It has unique metabolic pathways related to its lack of mitochondria, making it an ideal target for volatile organic compound profiling. <h3>Method</h3> Faecal gas headspace extraction and Gas Chromatography-Mass Spectrometry (GCMS) were used to extract and identify VOCs. Analytical tools including Metab,<sup>1</sup>R and Metaboanalyst<sup>2</sup>were subsequently used. Stool was obtained from patients with confirmed isolated <i>Giardia</i>infection, together with stool from subjects with diarrhoea but no identifiable infection, including <i>Giardia</i>, these acted as controls. Significant differences between the VOCs were then analysed. <h3>Results</h3> The composition of these compounds was dominated by Esters, Acids and Alcohols, respectively. With an absence of Amides, Alicyclic compounds, Ether compounds and Nitrogen Containing compounds. &gt;100 VOCs were identified across both the control and <i>Giardia</i>groups. Of these 10 were noted to be significantly different between the two groups (p &lt; 0.01). Three VOCs were identified with a significant predominance to the <i>Giardia</i>samples, 2,2,4,4-tetramethyloctan, acetic acid and 2,2,4,6,6-pentamethylhepatance (p &lt; 0.0001). 10 VOCs were found to be significantly different in terms of abundance (p &lt; 0.01), acetone and 2-butanone were the two most significantly different compounds, both demonstrating a p value of &lt;0.001 and both having down regulation in the <i>Giardia </i>samples. PLS-DA showed a good degree of separation. AUROC analysis gave 5 VOCs with an AUC between 0.8 and 0.93. <h3>Conclusion</h3> There is a significant difference in the VOC profile of stool from subjects infected with <i>Giardia spp</i>, when compared to non-infected controls, both in terms of prevalence and abundance. There is also a defined metabolic reason for this difference originating from the unique metabolic pathways seen in <i>Giardia</i>. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Aggio R, Villas-Bôas SG, Ruggiero K. Metab: an R package for high-throughput analysis of metabolomics data generated by GC-MS. <i>Bioinformatics (Oxford, England)</i>2011;<b>27</b>:2316–2318. doi:10.1093/bioinformatics/btr379 Xia J, Psychogios N, Young N, and Wishart DS. MetaboAnalyst: a web server for metabolomic data analysis and interpretation. Nucl Acids Res. 2009;37:W652–660.
GPs back government move to charge overseas visitors
Authors: Gareth Iacobucci
Journal: BMJ (2016)

GPs have backed moves to charge visitors from overseas for attending NHS general practices.

GPs at the BMA’s conference of local medical committees (LMCs), the bodies that represent GPs at a local level, in London on Friday 20 May voted to carry a motion calling for foreign visitors to be able to attend UK general practices but “only on a private fee-paying basis.”

After an electronic …
Geriatrics Guide
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible effects of early separation experiences on subsequent immune function in adult macaque monkeys
Authors: M Laudenslager, J P Capitanio, M Reite
Journal: American Journal of Psychiatry (1985)

The authors studied the immunological influences of maternal or peer separation in adult monkeys. Monkeys with early separation experiences were found to have reduced proliferative responses to B and T cell mitogens but no differences in other immunological parameters compared with nonseparated control subjects.
El Niño to Adversely Affect Children’s Health
Authors: M. J. Friedrich
Journal: JAMA (2016)

A strong El Niño weather pattern is putting millions of children at risk from hunger, disease, and lack of water, according to a report from the United Nations Children’s Fund (UNICEF) titled “A Wake-Up Call: El Niño’s Impact on Children” (http://uni.cf/1liy8Gc).
Sexual Function in Cancer Survivors: Updates to the NCCN Guidelines for Survivorship
Authors: Michelle E. Melisko, Joseph B. Narus
Journal: Journal of the National Comprehensive Cancer Network (2016)

By the year 2024, predictions estimate that there will be approximately 19 million cancer survivors in the United States, many of whom will experience the physical and/or psychosocial long-term effects of cancer and its treatment. Although sexual dysfunction is common among these individuals, causing increased distress and negatively impacting quality of life, this critical part of survivorship care is often underrecognized and undertreated. At the NCCN 21st Annual Conference, Drs. Melisko and Narus reviewed the sexual function recommendations in the NCCN Guidelines for Survivorship, offering practical strategies for assessing and managing both female and male sexual dysfunction.
Scintigraphic findings of dysplasia epiphysealis hemimelica: a case report.
Authors: ANA TEIXEIRA, ELBA DE CAMARGO ETCHEBEHERE, ALLAN SANTOS, MARIANA LIMA, CELSO RAMOS, EDWALDO CAMARGO
Journal: Clinical Nuclear Medicine (2001)

TEIXEIRA, ANA B. M. J. M.D.; DE CAMARGO ETCHEBEHERE, ELBA CRISTINA SÁ; SANTOS, ALLAN O. M.D.; LIMA, MARIANA C. L. M.D.; RAMOS, CELSO D. M.D.; CAMARGO, EDWALDO E. M.D., Ph.D. Author Information
Aberrant immunophenotype in acute myeloid leukemia (AML): High frequency and association with dysplasia
Authors: S. Dogra, J. P. Mangipudy, E. Asatiani, R. Gamez, P. Cohen, C. Kessler, B. Mavromatis, A. Shad, B. D. Cheson, M. Ozdemirli
Journal: Journal of Clinical Oncology (2007)

17504 Background: Asynchronous expression of immunophenotypic markers on AML myeloblasts has been well described, but the association of aberrant phenotype with morphologic subclasses has not been reported previously. Methods: Multiparameter flow cytometry (MFC) data were analyzed for all patients (pts) diagnosed with AML at our institution from 2000–2006. MFC was done on fresh bone marrow aspirate and/or peripheral blood samples using the following panel of monoclonal antibodies in triple staining: CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD11c, CD13, CD14, CD15, CD16, CD19, CD20, CD22, CD24, CD33, CD56, CD34, CD117, HLA-DR and TdT. Identification of myeloblasts was performed using Side Scatter (SS) characteristics and CD45 expression. Acute lymphoblastic leukemia (ALL) cases or cases with mixed lineage acute leukemia were excluded from the study. Results: We identified 76 pts with AML; median age 57, (range 10 weeks to 89 years), with 32 males and 44 females. The patients had the following French American British classification of AML: M0 (n=1), M1 (n=11), M2 (m=10), M3 (n=5), M4 (n=13), M5 (n=14), M6 (n=1), M7 (n=4) and not otherwise categorized non- M3 AML (n=17). Twenty two pts had AML with multilineage dysplasia (AML-MD) as classified by World Health Organization. Coexpression of TdT on myeloblasts was observed in 4 pts, one of these coexpressed CD5. T-cell lymphoid associated antigens (CD2, CD5 and/or CD7) were coexpressed on myeloblasts from12 pts. B cell lymphoid associated antigens (CD19 and/or CD20) were expressed on myeloblasts from11 pts. Both T and B cell lymphoid associated antigens were present on myeloblasts in 4 pts. Myeloblasts from 13 pts demonstrated the presence of the NK cell marker CD56. A total of 43 patients had AML with immunophenotypic lineage infidelity manifested by coexpression of one or more aberrant antigens on myeloblasts. The distribution of cases with lineage infidelity was higher in 22 pts with AML-MD (n=17, 77%) versus in 54 pts with no dysplasia (n=26, 48%), Chi square =5.4, p=0.02. Conclusions: Abnormal coexpression of lymphoid and NK cell markers was observed in significant number of AML pts and correlated with the presence of multilineage dysplasia. This finding may indicate an earlier stem cell origin of AML-MD. No significant financial relationships to disclose.
Abstract P6-08-05: Protein tyrosine kinase activity and miRNA expression profiling reveals differences according to progesterone-receptor-status in HER-2 negative breast cancer
Authors: A Tahiri, SV Satheesh, R de Wijn, T Lders, MR Aure, DA Quigley, IR Bukholm, A Hurtado, VN Kristensen, J Geisler
Journal: Cancer Research (2016)

Abstract Background: Kinases are considered as promising source of biomarkers for diagnostic, prognostic and therapeutic purposes in cancer patients. We assessed tyrosine kinase activity in 39 primary breast cancer samples that were all hormone receptor positive (ER+ and/or PR+) with differential HER-2 status, using microarray technology. Methods: Pamchip® peptide microarrays were used to measure the activity of protein tyrosine kinases in 32 breast cancer samples. The breast cancer cell lines MCF-7, BT474 and ZR75-1, was studied for kinase activity, both untreated and treated with estradiol. Results: Results showed differences in phosphorylation amongst breast cancer samples. A total of 37 peptide kinases were highly phosphorylated in a group of breast cancer samples representing 33 protein tyrosine kinases involved in cancer pathways and immunological responses. In vitro studies with breast cancer cell lines exhibited the same phosphorylation profiles, but increased phosphorylation was only observed in one cell line, ZR75-1. Eliminating HER-2 positive samples, we obtained differences in phosphorylation profiles based on PR-status only. Samples lacking PR-expression exhibited higher kinase activity of downstream kinases compared to PR-positive samples. Similar results were obtained with miRNA expression profiles of 31 breast cancer samples. Five miRNAs were identified to be significantly differentially expressed (p &amp;lt; 0.05) between PR-negative and PR-positive samples. This effect was even stronger when eliminating HER-2 positive samples, with 13 miRNAs exhibiting significant differential expression based on PR-status. Conclusion: Although our data are based on a small dataset, the lack of PR expression seems to have a profound effect on tyrosine kinase activity and miRNA expression in HER-2 negative breast cancers without any effect on gene expression. This indicates that regulatory and functional molecules might exhibit phenotypical features of cancer that cannot be explained by gene expression alone. Citation Format: Tahiri A, Satheesh SV, de Wijn R, Lders T, Aure MR, Quigley DA, Bukholm IR, Hurtado A, Kristensen VN, Geisler J. Protein tyrosine kinase activity and miRNA expression profiling reveals differences according to progesterone-receptor-status in HER-2 negative breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-08-05.
Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes
Authors: H Dolatshad, A Pellagatti, F G Liberante, M Llorian, E Repapi, V Steeples, S Roy, L Scifo, R N Armstrong, J Shaw, B H Yip, S Killick, R Kušec, S Taylor, K I Mills, K I Savage, C W J Smith, J Boultwood
Journal: Leukemia (2016)

The splicing factor SF3B1 is the most frequently mutated gene in myelodysplastic syndromes (MDS), and is strongly associated with the presence of ring sideroblasts (RS). We have performed a systematic analysis of cryptic splicing abnormalities from RNA sequencing data on hematopoietic stem cells (HSCs) of SF3B1-mutant MDS cases with RS. Aberrant splicing events in many downstream target genes were identified and cryptic 3′ splice site usage was a frequent event in SF3B1-mutant MDS. The iron transporter ABCB7 is a well-recognized candidate gene showing marked downregulation in MDS with RS. Our analysis unveiled aberrant ABCB7 splicing, due to usage of an alternative 3′ splice site in MDS patient samples, giving rise to a premature termination codon in the ABCB7 mRNA. Treatment of cultured SF3B1-mutant MDS erythroblasts and a CRISPR/Cas9-generated SF3B1-mutant cell line with the nonsense-mediated decay (NMD) inhibitor cycloheximide showed that the aberrantly spliced ABCB7 transcript is targeted by NMD. We describe cryptic splicing events in the HSCs of SF3B1-mutant MDS, and our data support a model in which NMD-induced downregulation of the iron exporter ABCB7 mRNA transcript resulting from aberrant splicing caused by mutant SF3B1 underlies the increased mitochondrial iron accumulation found in MDS patients with RS.
Influenza A(H1N1)v in the southern hemisphere - lessons to learn for Europe?
Authors: E Depoortere, J Mantero, A Lenglet, P Kreidl, D Coulombier
Journal: Eurosurveillance (2009)

Preview this article: Influenza A(H1N1)v in the southern hemisphere - lessons to learn for Europe?, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/14/24/art19246-en-1.gif
The life of psychiatry
Authors: B S Brown
Journal: American Journal of Psychiatry (1976)

Focusing on the definition, scope, and role of psychiatry today, the author discusses whether psychiatry is primarily medical, whether it is overstepping its boundaries in attempting to treat problems of living, and whether it is too involved with social questions. On the basis of an examination of the current scientific base of psychiatry, he predicts that psychiatry will continue to grow in size and diversity, that it will refocus substantially on biological issues, that it will become more humble about what it can do with regard to social problems, and that it will continue to yield new therapeutic measures and techniques.
Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis
Authors: Charles D Burger
Journal: New England Journal of Medicine (2011)

To the Editor: McCormack and colleagues (April 28 issue) 1 state that the decline in lung function in patients with lymphangioleiomyomatosis (LAM) resumed in the sirolimus group after treatment ended and paralleled the reduction in the placebo group. Figure 2A of the article shows the speed of forced expiratory volume in 1 second (FEV 1 ) in the two study groups during both the treatment phase and the observation phase. In the placebo group, the decline in FEV 1 accelerated during the observation phase, as compared with the treatment phase. This might suggest that patients with milder LAM withdrew from the study before the obser vation phase began. If untreated patients actually had a steady rate of decline, then the discontinu ation of sirolimus would seem, in comparison, to be associated with an accelerated decline. LAM is characterized by the infiltration of smooth-muscle cells and formation of parenchy
Long-term affective and cognitive outcome in depressed older adults
Authors: A Stoudemire, C D Hill, R Morris, D Martino-Saltzman, B Lewison
Journal: American Journal of Psychiatry (1993)

The purpose of this naturalistic study was to examine the long-term (15 months and 4 years) cognitive and affective outcome following treatment with either cyclic antidepressants or ECT in depressed older adults.Fifty-five patients meeting criteria for major depression were rated as to cognitive impairment and were treated as clinically indicated with either a cyclic antidepressant or ECT. Long-term outcome was determined through psychometric retesting 15 months (N = 47) and approximately 4 years (N = 44) after treatment.Analysis of 15-month and 4-year outcome evaluations revealed that the majority of patients improved over time with respect to their depression, regardless of whether they exhibited pretreatment cognitive impairment or were treated with cyclic antidepressants or ECT. Fifteen months and 4 years after treatment, 72.3% and 83.7% of patients, respectively, exhibited clinically meaningful improvement. However, patients given both cyclic antidepressants and ECT demonstrated a relatively high rate of rehospitalization (50%) over the course of the 4 years. Except for patients who developed dementia, cognitive functioning remained stable or improved for the majority of patients. In patients who received ECT, those with normal pretreatment cognition had stable cognitive functioning over time and those who had pretreatment cognitive dysfunction showed improvement over the 4-year follow-up period.Results of this study indicate that the long-term prognosis of depression in older adults is generally favorable, although they may be prone to relapse and recurrence, which points to the need for rigorous monitoring and follow-up care.
Nanoscale Particulate Matter from Urban Traffic Rapidly Induces Oxidative Stress and Inflammation in Olfactory Epithelium with Concomitant Effects on Brain
Authors: Hank Cheng, Arian Saffari, Constantinos Sioutas, Henry J. Forman, Todd E. Morgan, Caleb E. Finch
Journal: Environmental Health Perspectives (2016)

Background:Rodent models for urban air pollution show consistent induction of inflammatory responses in major brain regions. However, the initial impact of air pollution particulate material on olfactory gateways has not been reported.Objective:We evaluated the olfactory neuroepithelium (OE) and brain regional responses to a nanosized subfraction of urban traffic ultrafine particulate matter (nPM, < 200 nm) in vivo, ex vivo, and in vitro.Methods:Adult mice were exposed to reaerosolized nPM for 5, 20, and 45 cumulative hours over 3 weeks. The OE, the olfactory bulb (OB), the cerebral cortex, and the cerebellum were analyzed for oxidative stress and inflammatory responses. Acute responses of the OE to liquid nPM suspensions were studied with ex vivo and primary OE cultures.Results:After exposure to nPM, the OE and OB had rapid increases of 4-hydroxy-2-nonenal (4-HNE) and 3-nitrotyrosine (3-NT) protein adducts, whereas the cerebral cortex and cerebellum did not respond at any time. All brain regions showed increased levels of tumor necrosis factor-α (TNFα) protein by 45 hr, with earlier induction of TNFα mRNA in OE and OB. These responses corresponded to in vitro OE and mixed glial responses, with rapid induction of nitrite and inducible nitric oxide synthase (iNOS), followed by induction of TNFα.Conclusions:These findings show the differential time course of oxidative stress and inflammatory responses to nPM between the OE and the brain. Slow cumulative transport of inhaled nPM into the brain may contribute to delayed responses of proximal and distal brain regions, with potential input from systemic factors.Citation:Cheng H, Saffari A, Sioutas C, Forman HJ, Morgan TE, Finch CE. 2016. Nanoscale particulate matter from urban traffic rapidly induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain. Environ Health Perspect 124:1537–1546; http://dx.doi.org/10.1289/EHP134