tbuckley/cabot-search huggingface dataset:
FRI0245 How Reliable is the Scoring of Msasss in Clinical Practice in Centers Participating in Desir? Comparison with the Gold Standard Central Reading: Table 1
Authors: M. de Hooge, P. Claudepierre, A. Feydy, M. Reijnierse, A. Saraux, M. Dougados, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Spinal X-rays are considered as gold standard for assessing structural damage in the spine in AS, and a scoring system, the modified Stoke Ankylosing Spondylitis <i>Spinal</i> Score (mSASSS) is the preferred assessment method. In clinical studies and therapeutic trials, the mSASSS scoring process is usually done by ≥1 trained readers. In daily practice, the ability of rheumatologists and radiologists to adequately use the mSASSS without a specific training is unknown. In addition, it is not known what the impact would be in studies when using the score of multiple readers in various centres as in daily practice, instead of using a centralized scoring with a few trained readers <h3>Objectives</h3> To compare the results of the mSASSS of the local reading of baseline spinal X-rays to the centralized reading as the gold standard <h3>Methods</h3> Patients aged 18-50 with recent chronic back pain (≥3 months, ≤3 years) from 25 participating centers in France were included in the DESIR (Devenir des Spondylarthropathies Indifferenciées Récentes) -cohort (n=708). All available baseline X-rays of cervical and lumbar spine were scored by the local radiologist/rheumatologist who might have access to clinical data, according to the mSASSS scoring method. In addition, 2 well-calibrated centralized readers independently scored the same X-rays, blinded for any other data. In case the centralized readers disagreed, an experienced radiologist served as adjudicator. Agreement between the 2 centralized readers, and between the local and centralized scores was calculated (Kappa; percentage agreement). To calculate the agreement between readers a cut-off of ≥1 for mSASSS was used. When comparing centralized readers with local readers the mSASSS of the centralized readers was combined <h3>Results</h3> Patients with complete X- ray data (n=664) were included in these analyses. The large majority of patients had a normal mSASSS both scored by the central and local readers. The agreement between the 2 centralized readers was 89.3% with a kappa of 0.50 (see Table 1). Comparing the local readings with the centralized scores there was an agreement in 72.2% of the cases with a kappa of 0.19. The local readers scored an mSASSS ≥1 in 169 cases, while this was in 119 cases if scored by central readers <h3>Conclusions</h3> The agreement between two trained central readers is better than between central and local readers. Local readers overestimate damage in the spine in comparison to the gold standard of central reading <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1522
CLINICAL OUTCOMES OF MULTIPLE CHRONIC TOTAL OCCLUSIONS IN CORONARY ARTERIES ACCORDING TO THREE THERAPEUTIC STRATEGIES: BYPASS SURGERY, PERCUTANEOUS INTERVENTION AND MEDICATION
Authors: Bum Sung Kim, Jeong Hoon Yang, Jin Kyung Hwang, Ji Won Hwang, Ji Hoon Moon, Jin-Ho Choi, Seung-Hyuk Choi, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2015)
Nifedipine in Asymptomatic Patients with Severe Aortic Regurgitation and Normal Left Ventricular Function
Authors: Roldano Scognamiglio, Shahbudin H. Rahimtoola, Giuseppe Fasoli, Stefano Nistri, Sergio Dalla Volta
Journal: New England Journal of Medicine (1994)

Vasodilator therapy with nifedipine reduces left ventricular volume and mass and increases the ejection fraction in asymptomatic patients with severe aortic regurgitation.
S86 Formation of Oxidised Alpha-1 Antitrypsin Induces Inflammatory Response in Human Bronchial Epithelial Cells
Authors: S Alam, Z Li, R Mahadeva
Journal: Thorax (2012)

Alpha-1 antitrypsin (AT) is a major anti-elastase and protects the lung from uncontrolled elastolysis. AT is highly susceptible to oxidation in vivo. We investigated the role of Ox-AT in the inflammatory response. Lung epithelial (A549 and NHBE) cells were exposed to 25% CSE. Ox-AT, TNF-α, IL-6, IL-8, MCP-1, NF-kB and AP-1 were assessed by ELISA or RT-PCR. Anti-Ox-AT mAb (3F4, 10µg/ml) and N-acetylcysteine (NAC, 10<sup>–3</sup>M) were used to probe the effect of Ox-AT. CSE (compared to PBS) significantly induced TNF-α (440.4±76.8pg/ml vs. 17.5±2.6, p&lt;0.001) at 24h and induced IL-6 at 72h (354.7±38.4pg/ml vs. 17.6±2, p&lt;0.001). CSE induced TNF-α mRNA at 0.5h (p&lt;0.001) and IL-6 mRNA at 3h (p&lt;0.001). CSE (compared to PBS) activated NF-κB (OD at 405nm, 1.325 vs. 0.315, p&lt;0.001) and AP-1 (OD at 405nm, 0.988 vs. 0.296, p&lt;0.001) at 0.5h. At 24h CSE (compared to PBS) resulted in significant level of Ox-AT (mean±SEM, 1372.8±162.8ng/ml vs. undetectable, p&lt;0.001) and induced IL-8 (1415.7±92.5pg/ml vs. 57.2±10, p&lt;0.001) and MCP-1 (15683±713pg/ml vs. 2208±157, p&lt;0.001). At 24h Ox-AT (compared to PBS) significantly induced IL-8 (1168±9pg/ml vs. 110±8, p=0.008) and MCP-1 (14500±424pg/ml vs. 4225±470, p=0.005) in A549 cells. NAC inhibited Ox-AT, TNF-α, IL-6, IL-8, MCP-1, NF-κB and AP-1 (p&lt;0.001 for all). 3F4 selectively inhibited Ox-AT, IL-8, MCP-1, NF-κB and AP-1 (p&lt;0.001 for all). These findings were confirmed with NHBE cells. In conclusion, Ox-AT generated in the airway interacts directly with epithelial cells to release MCP-1 and IL-8, so enhancing lung inflammation. This mechanism could potentially contribute to the abnormal inflammatory response seen in COPD independent of CSE. Anti-oxidant treatment inhibited both CSE and Ox-AT induced inflammatory response further supporting a role for these agents in COPD.
OP0146 Treatment with biologic agents improves the prognosis of patients with rheumatoid arthritis and amyloidosis
Authors: T. Kuroda, D. Kobayashi, H. Sato, T. Nakatsue, Y. Wada, S. Murakami, M. Nakano, I. Narita
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Reactive amyloid A (AA) amyloidosis is a serious and life-threatening systemic complication of rheumatoid arthritis (RA).Recently, therapy with biologic agents such as anti- tumor necrosis factor (TNF) and anti- interleukin (IL)-6 antibodies has developed against a background of increased understanding of the pathogenesis of rheumatoid arthritis (RA), representing a tremendous advance in the management of RA. However, the prognosis of amyloid patients treated with biologics has not yet been clearly investigated. <h3>Objectives</h3> Our purpose was to examine the safety of therapy with anti-tumor necrosis factor and anti-interleukin-6 biologic agents in RA patients with reactive AA amyloidosis, together with prognosis and hemodialysis (HD)-free survival, in comparison with AA amyloidosis patients without such therapy. <h3>Methods</h3> One hundred thirty-three patients with an established diagnosis of reactive AA amyloidosis participated in the study. Clinical data were assessed from the patient records at the time of amyloid detection and administration of biologics. Survival was calculated from the date when amyloid was first demonstrated histologically until the time of death, or up to end of 2010, for the patients who were still alive. Patients who had been started on HD were selected for inclusion only after the presence of amyloid had been demonstrated. Assessment of the association of various factors with survival was performed on the date of the original diagnosis. <h3>Results</h3> Fifty-three patients were treated with biologic agents (biologic group) and 80 were not (non-biologic group). Survival rate was significantly higher in the biologic group than in the non-biologic group (p=0.001). Nine patients in the biologics group and 33 in the non-biologic group were started on HD. HD-free survival was significantly higher in the biologic group (p=0.00004). <h3>Conclusions</h3> Patients with amyloidosis have a higher mortality rate, but that the use of biologic agents reduces mortality among them. Additionally, the use of biologics improves the HD-free survival rate. <h3>References</h3> [1]Lunt M, et al. Arthritis Rheum 2010; 62: 3145-53. [2]Dixon WG, et al. Ann Rheum Dis 2010; 69: 1180-91. [3]Kuroda T, et al. Clin Rheumatol 2006; 25: 498-505. [4]Kuroda T, et al. J Rheumatol 2009; 36:2409-15. <h3>Disclosure of Interest</h3> None Declared
Preliminary Studies of Tolerance to Contact Sensitization in Carcinogen-Fed Guinea Pigs&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Jerome R. Pomeranz, M.D.
Journal: JNCI Journal of the National Cancer Institute (1972)

The oral administration of a single large dose of 7,12-dimethylbenz[a]anthracene, benzo[a]pyrene, and 3-methylcholanthrene in corn oil to guinea pigs made most recipients unresponsive to subsequent contact sensitization with the carcinogen. The absence of responsiveness was comparable to the tolerant state induced by feeding simple chemical haptens, in terms of specificity and persistence.
FRI0104 The cumulative rate of arthroplasty in patients with rheumatoid arthritis has not declined over the last three decades: data from a private rheumatologic center.
Authors: A. M. Bertoli, V. Barbá, I. Strusberg
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The early implementation of methotrexate and biologic drugs are known to improve prognosis in rheumatoid arthritis (RA) patients. Arthroplasty can be considered as an indirect indicator of lack of tight control. <h3>Objectives</h3> To compare the rate of arthroplasty (regardless of its cause) in patients with diagnosis of RA in three consecutive decades (80´s, 90´s and first decade of 21st century and to describe the variables associated with the occurrence of the event ¨arthroplasty¨. <h3>Methods</h3> This was a retrospective analysis that included 1258 patients with RA (as per the 1987 ACR criteria) who were diagnosed between January 1980 and December 2009. The relationship between demographic (gender, age at first symptom and at diagnosis), clinical (date of diagnosis, diagnosis delay, tobacco use, presence of rheumatoid factor, sedimentation rate and joint erosions at diagnosis, extra-articular manifestations, time to first arthroplasty, replaced joints, total number of arthroplasties and follow-up time) and therapeutic (number and delay in the use of DMARD`s, methotrexate and biologic agents since the diagnosis) domains was examined. The cumulative rate of arthroplasty was estimated using the Kaplan-Meier method and the variables associated with this event analyzed with a Cox regression conditional model. Variables with p value ≤ 0.05 were considered statistically significant. <h3>Results</h3> Patients were predominantly females (81.5%) and they had a a mean (SD) age at diagnosis of 45 (14.3) years. The median (IQR) follow-up time was 39 (88) months. We identified 111 (9%) patients who had at least one arthroplasty and a total of 146 arthroplasties (hip= 96, knee= 47, metacarpophalangeal= 2, shoulder= 1). Among patients diagnosed during the 80's (N= 215), 45 (20.9%) had at least one arthroplasty, during the 90's (N= 430), 46 (10.7%) had at least one arthroplasty and during the first decade of this century (N= 613), 20 (3.3%). The cumulative rate of arthroplasty at 5 years was 4%, 3% and 6% in the 3 decades, respectively, and at 10 years it was 13%, 14% y 13% (log rank test= 1.37; <i>p</i>= 0.50). In the multivariate analysis, the use of methotrexate (HR= 0.51, CI95% 0.43-0.59; <i>p</i>&lt; 0.001) was protective for the event "arthroplasty". <h3>Conclusions</h3> In this study, although the absolute risk of arthroplasty clearly decreases over the last three decades, the cumulative rate does not show the same trend. These disappointing data may not reflect yet the fully implementation of new treatment strategies in this patient population. The utilization of MTX, which is known to be a low cost and effective treatment intervention, was protective for the occurrence of the event arthroplasty. <h3>Disclosure of Interest</h3> None Declared
Some Effects of Ankylosing Spondylitis on Pulmonary Gas Exchange
Authors: Attilio D. Renzetti, William Nicholas, Robert E. Dutton, Leo Jivoff
Journal: New England Journal of Medicine (1960)

STUDIES of pulmonary function in patients with ankylosing spondylitis have established that the vital capacity is frequently reduced and that the maximum ventilatory capacity is decreased proportionately less than the vital capacity.1 2 3 In the most comprehensive survey of ventilatory function in this disease reported to date, Rogan, Needham and McDonald3 demonstrated that the reductions in vital capacity and total lung capacity were the most striking and consistently abnormal findings, and showed the best correlation with the severity of the disease as judged by radiologic criteria. Their studies also showed that the ratio of residual volume to total lung capacity was . . .
The Value of Tc-99m Red Blood Cell SPECT in Differentiating Giant Cavernous Hemangioma of the Liver from Other Liver Solid Masses
Authors: Cheng-Chien Tsai, Tzu-Chen Yen, Kai-Yuan Tzen
Journal: Clinical Nuclear Medicine (2002)

Giant cavernous hemangioma (GCH) of the liver has the potential risk for rupture and bleeding, which may cause sudden death. The purpose of this retrospective study was to compare the value of Tc-99m-labeled red blood cell (RBC) SPECT with ultrasound (US) in differentiating GCH from other solid liver masses.Twenty-two patients with giant solid liver masses, equal to or greater than 8 cm in at least one dimension, identified by US were examined by Tc-99m RBC SPECT. Final diagnoses were based on findings of surgery, biopsy or follow-up by US for a minimum of 24 months after the scan.In all, US detected 23 giant liver masses in 22 patients (3 men, 19 women). Eighteen GCHs were detected in 17 patients by Tc-99m RBC SPECT. Nine showed a homogeneously increased blood pool; 9 revealed peripheral high, but central low, uptake. The US patterns in these 18 GCHs were mixed-echoic in 12, hyperechoic in 4, and hypoechoic in 2. The other five large liver tumors, all proved by operation, had no increased uptake area with Tc-99m RBC SPECT. The US patterns of these were mixed-echoic in 3, hyperechoic in 1, and hypoechoic in 1.Our study showed that there was no specific US pattern that would differentiate GCHs from other giant liver masses. Tc-99m RBC SPECT appeared to separate them clearly.
Sleep Deprivation and Elective Surgery
Authors: Carlos A. Pellegrini, L.D. Britt, David B. Hoyt
Journal: New England Journal of Medicine (2010)

To the Editor: The Perspective article by Nurok et al. in this issue of the Journal 1 is a timely one that clearly articulates the surgical profession's concerns about the effects of sleep deprivation on performance. The American College of Surgeons (ACS) agrees that fatigue has a detrimental effect on both cognitive and technical performance; however, we believe that the solution the authors offer — mandatory disclosure — is unwarranted. Rather, we maintain that surgeons should be trained to identify and address this problem. Surgeons who meet the ACS's standards of professionalism and ethics are committed to delivering safe surgical care . . .
AB0762 Biological therapy for large vessel vasculitis: A systematic review
Authors: L. Silva, R. Blanco, V. Martínez-Taboada, E. Loza, I. Rúa-Figueroa, S. Muñoz-Fernández, J.M. Pego
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Treatment of large-vessel vasculitis (LVV) is mainly based on high doses of corticosteroids (CS). There is controversy on the use of methotrexate and azathioprine as steroid-sparing. Cytokines like IL-6 or TNF could play an important role in the pathogenesis of LVV, thus could be targets in the treatment of LVV patients. <h3>Objectives</h3> To systematically review the efficacy and safety of biological agents in the treatment of LVV. <h3>Methods</h3> We systematically searched MEDLINE, EMBASE and the Cochrane Central Register of Controlled Trials up to October 2011 using a comprehensive search strategy for giant cell arteritis (GCA), Takayasu’s arteritis (TA), biologic agents, efficacy and safety (mesh terms and text words). Selection criteria were predefined by protocol. We selected meta-analysis, systematic literature reviews, clinical trials (CT), cohort studies and case series with &gt;3 cases, that included &gt;18 year-old patients with GCA or TA on biologic drugs. Studies including patients with Behçet disease, cryoglobulinemia, ANCA associated vasculitis, secondary vasculitis, and basic science studies were excluded. Title and abstract selection and subsequent detailed review of selected articles were independently performed by two reviewers. The included studies quality was graded using the Oxford Levels of Evidence Scale, and results expressed as level of evidence (LE), recommendation grade (RG). <h3>Results</h3> The search strategy identified 2762 potentially relevant articles, of which 80 were selected for full paper review. Finally, 3 were included in the analysis and 3 were found by handsearch. We included 2 randomized CT and 4 case series, which accounted for 112 patients. Main characteristics and results of the included studies are shown in the table. <h3>Conclusions</h3> Infliximab is not more effective than CS in the induction of remission of CGA patients (LE 1b; GR A) but could be effective (remission induction, CS sparing) in CS-refractory TA (LE 4; GR C). Etanercept has a role as steroid-sparing agent in GCA with CS related severe adverse events (LE 1b; GR A) and could be effective (remission induction, CS sparing) in CS-refractory TA (LE 4; GR C). Tocilizumab might be effective (remission induction, CS sparing) in LVV (LE 4; GR C). <h3>Disclosure of Interest</h3> None Declared
Abstract 3080: MYC antagonizes imatinib-induced differentiation in chronic myeloid leukemia cells through downregulation of p27KIP1
Authors: Javier Leon, M. Teresa Gomez-Casares, Nuria Ferrandiz, Carmen E. Lopez, Eva Garcia-Alegria, Marta Albajar, Jose P Vaque, Gabriel Bretones, M. Dolores Delgado
Journal: Cancer Research (2012)

Abstract Imatinib is a BCR-ABL kinase inhibitor and the most used drug in chronic myeloid leukemia (CML). MYC (c-Myc) is a transcription factor frequently deregulated in human cancer that exerts multiple biological activities, including differentiation inhibition. We found that MYC expression is higher in bone marrow cells form CML patients at diagnosis, as compared with healthy controls. Moreover, high MYC levels at diagnosis correlated with a poorer response to imatinib treatment. One of the major characteristics of CML progression is the loss of cell differentiation. We showed that low concentrations of imatinib induce erythroid differentiation in the CML-derived K562 cell line. We have studied the effect of MYC on the differentiation induced by imatinib using K562 sublines carrying inducible (by zinc cation) or activable (by 4-hydoxy-tamoxifen) MYC alleles. In both cell lines, MYC largely prevented the erythroid differentiation induced by imatinib. The differentiation inhibition mediated by MYC is not due to increased proliferation of MYC-expressing cells or enhanced apoptosis of differentiated cells in the presence of MYC. We previously reported that p27/Kip1 (p27) overexpression induces erythroid differentiation in K562. Thus, we explored the effect of imatinib on p27 levels and we found that imatinib up-regulated p27 in a time- and concentration-dependent manner. siRNA-mediated silencing of p27 antagonized the erythroid differentiation induced by imatinib, indicating that p27 up-regulation is at least in part responsible for differentiation. MYC abrogated the imatinib-induced up-regulation of p27KIP1 concomitantly with the differentiation inhibition, suggesting that MYC inhibits imatinib-mediated differentiation of K562 cells by antagonizing p27 up-regulation. We previously reported that MYC induced SKP2, a component of the ubiquitin ligase complex that targets p27 for degradation. MYC was able to induce SKP2 in the presence of imatinib. Thus, MYC-mediated inhibition of the differentiating effect of imatinib in CML cells is in part a consequence of the SKP2 induction of MYC, which in turn would down-regulate p27. The results suggest that, although MYC deregulation does not directly confer resistance to imatinib, it might be a factor that contributes to progression of CML through the inhibition of differentiation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3080. doi:1538-7445.AM2012-3080
GW25-e0501 Association of glucose transporter 4 genetic Polymorphisms with obstructive sleep apnea syndrome in Han Chinese general population: a cross-section study
Authors: Ting Yin, Nan fang Li, Mulalibieke Heizhati, Juhong Zhang, Jingjing Zhang, Ling Zhou, Guijuan Chang, Nanfang Li
Journal: Journal of the American College of Cardiology (2014)
Abstract 1565: Significance of elemental content and distribution profiles in assessing established cell lines as surrogates for cancer tissues from two different organs.
Authors: Ibrahim O. Farah, Zikri Arslan, Wellington K. Ayensu
Journal: Cancer Research (2013)

Abstract Studies have shown that defective metal homeostasis is very essential to the development of the cancer phenotype in many cancers including lung and liver carcinomas. Low Zn levels as well as overexpression of metalothioneins were implicated in the development and progression of various cancers. Wider elemental profiles that relate cancer and normal phenotypes with regards to metal homeostasis were not well elucidated in the literature. To this end, established cell lines are currently used as accepted models for studying cancer but the level of their representation of actual cancer tissues was not clear. This study is attempting to assess the relevance of cell lines currently is use as surrogates for cancer and establish their relationship to actual normal and cancer tissues from humans. We hypothesize that elemental content and distribution profiles in cancer and normal tissue are significantly different from those possessed by established cell lines. We used Inductivity Coupled Plasma (ICP-Mass Spectroscopy) for lung and liver samples obtained from normal and cancer human cadaver tissues (US Biomax) and cell models of lung and liver carcinomas; the A549 and HepG2 cell lines (ATCC), to analyze for elements and test the hypothesis. Samples prepared using standardized digestion procedures were loaded onto the ICP-MS equipment to test for a profile consisting of 12 elements, namely, Zn, Cu, Fe, Mg, Mn, Ca, Al, Co, Ba, Cr, Ni and Se. Analysis of data showed significant variations in elemental content and distribution profiles between the cell models and actual tissues consistent with the hypothesis. It is concluded that elemental homeostasis is essential for normal tissue function and that shifts in their distribution and content are essential in determining the use of cell models as surrogates for studying cancer. These results are promising and warrant further studies to confirm the relevance of cell line models in relation to their use as screening tools for examining targeted cancer therapeutics. Citation Format: Ibrahim O. Farah, Zikri Arslan, Wellington K. Ayensu. Significance of elemental content and distribution profiles in assessing established cell lines as surrogates for cancer tissues from two different organs. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1565. doi:10.1158/1538-7445.AM2013-1565