tbuckley/cabot-search huggingface dataset:
Postremission therapy for the younger adult patient with acute myelogenous leukemia: defining a role for transplantation.
Authors: D D Hurd
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.9.1636 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8204125 Postremission therapy for the younger adult patient with acute myelogenous leukemia: defining a role for transplantation. D D HurdxD D HurdSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.9.1636 First Page PDF © 1993 by American Society of Clinical Oncology
Urban Dust Microbiome: Impact on Later Atopy and Wheezing
Authors: Christina Tischer, Fabian Weikl, Alexander J. Probst, Marie Standl, Joachim Heinrich, Karin Pritsch
Journal: Environmental Health Perspectives (2016)

Investigations in urban areas have just begun to explore how the indoor dust microbiome may affect the pathogenesis of asthma and allery.We aimed to investigate the early fungal and bacterial microbiome in house dust with allergic sensitization and wheezing later in childhood.Individual dust samples from 189 homes of the LISAplus birth cohort study were collected shortly after birth from living room floors and profiled for fungal and bacterial microbiome. Fungal and bacterial diversity was assessed with terminal restriction fragment length polymorphism (tRFLP) and defined by Simpson's Diversity Index. Information on wheezing outcomes and covariates until the age of 10 years was obtained by parent questionnaires. Information on specific allergic sensitization was available at child's age 6 and 10 years. Logistic regression and general estimation equation (GEE) models were used to examine the relationship between microbial diversity and health outcomes.Adjusted logistic regression analyses revealed a significantly reduced risk of developing sensitization to aero-allergens at 6 years and ever wheezing until the age of 10 years for exposure to higher fungal diversity [adjusted odds ratio (aOR) = 0.26 (95% CI: 0.10, 0.70), and 0.42 (95% CI: 0.18, 0.96), respectively]. The associations were attenuated for the longitudinal analyses (GEE) until the age of 10 years. There was no association between higher exposure to bacterial diversity and the tested health outcomes.Higher early exposure to fungal diversity might help to prevent a child from developing sensitization to aero-allergens in early childhood, but the reasons for attenuated effects in later childhood require further prospective studies. Citation: Tischer C, Weikl F, Probst AJ, Standl M, Heinrich J, Pritsch K. 2016. Urban dust microbiome: impact on later atopy and wheezing. Environ Health Perspect 124:1919-1923; http://dx.doi.org/10.1289/EHP158.
Case 9-1975
Authors: Oliver Wrong, Robert T. McCluskey
Journal: New England Journal of Medicine (1975)

Presentation of CaseA 14-year-old boy was admitted to the hospital because of renal failure.He was well until 19 months previously, when he noticed stiffness and pain in the hips after ice-skating. Investigation revealed azotemia and anemia, and he entered another hospital.As a young child the patient had experienced repeated respiratory-tract infections and polyuria, with a need to void once or twice during each night. He had taken no medication. There was no family history of renal disease or anemia.The temperature was 36.9° C, the pulse 100, and the respirations 20. The blood pressure was 130/90 mm . . .
Residual mass and gallium scanning.
Authors: D E Joshua, A F McLaughlin, H Kronenberg, G J Bautovich, J G Morris, B R Wylie, A E Southee, J Gibson
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.1.144 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2909666 Residual mass and gallium scanning. D E JoshuaxD E JoshuaSearch for articles by this author , A F McLaughlinxA F McLaughlinSearch for articles by this author , H KronenbergxH KronenbergSearch for articles by this author , G J BautovichxG J BautovichSearch for articles by this author , J G MorrisxJ G MorrisSearch for articles by this author , B R WyliexB R WylieSearch for articles by this author , A E SoutheexA E SoutheeSearch for articles by this author , J GibsonxJ GibsonSearch for articles by this author Show More https://doi.org/10.1200/JCO.1989.7.1.144 PDF "Residual mass and gallium scanning.." Journal of Clinical Oncology, 7(1), pp. 144–145© 1989 by American Society of Clinical Oncology
The Genetic Detectives
Authors: Mary Carmichael
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The 24-hour lithium level as a prognosticator of dosage requirements: a 2-year follow-up study
Authors: T B Cooper, G M Simpson
Journal: American Journal of Psychiatry (1976)

The authors have previously described a technique whereby individual lithium dosage requirements can be predicted from 24-hour blood samples. Further experience over a 2-year period has shown the predictions to be reproducible over time. A micromethod for lithium determination is described, as are several cases in which aberrant results were found to indicate inadequate laboratory techniques or patients' failure to take medication. Because the technique reveals immediately those patients at the extremes of dosage ranges, toxicity and the need for frequent sampling can be avoided.
Nonalcoholic Fatty Liver Disease Is Associated With Ventricular Arrhythmias in Patients With Type 2 Diabetes Referred for Clinically Indicated 24-Hour Holter Monitoring
Authors: Alessandro Mantovani, Antonio Rigamonti, Stefano Bonapace, Bruna Bolzan, Matteo Pernigo, Giovanni Morani, Lorenzo Franceschini, Corinna Bergamini, Lorenzo Bertolini, Filippo Valbusa, Riccardo Rigolon, Isabella Pichiri, Giacomo Zoppini, Enzo Bonora, Francesco Violi, Giovanni Targher
Journal: Diabetes Care (2016)

OBJECTIVE Recent studies have suggested that nonalcoholic fatty liver disease (NAFLD) is associated with an increased risk of heart rate–corrected QT interval prolongation and atrial fibrillation in patients with type 2 diabetes. Currently, no data exist regarding the relationship between NAFLD and ventricular arrhythmias in this patient population. RESEARCH DESIGN AND METHODS We retrospectively analyzed the data of 330 outpatients with type 2 diabetes without preexisting atrial fibrillation, end-stage renal disease, or known liver diseases who had undergone 24-h Holter monitoring for clinical reasons between 2013 and 2015. Ventricular arrhythmias were defined as the presence of nonsustained ventricular tachycardia (VT), &amp;gt;30 premature ventricular complexes (PVCs) per hour, or both. NAFLD was diagnosed by ultrasonography. RESULTS Compared with patients without NAFLD, those with NAFLD (n = 238, 72%) had a significantly higher prevalence of &amp;gt;30 PVCs/h (19.3% vs. 6.5%, P &amp;lt; 0.005), nonsustained VT (14.7% vs. 4.3%, P &amp;lt; 0.005), or both (27.3% vs. 9.8%, P &amp;lt; 0.001). NAFLD was associated with a 3.5-fold increased risk of ventricular arrhythmias (unadjusted odds ratio [OR] 3.47 [95% CI 1.65–7.30], P &amp;lt; 0.001). This association remained significant even after adjusting for age, sex, BMI, smoking, hypertension, ischemic heart disease, valvular heart disease, chronic kidney disease, chronic obstructive pulmonary disease, serum γ-glutamyltransferase levels, medication use, and left ventricular ejection fraction (adjusted OR 3.01 [95% CI 1.26–7.17], P = 0.013). CONCLUSIONS This is the first observational study to show that NAFLD is independently associated with an increased risk of prevalent ventricular arrhythmias in patients with type 2 diabetes.
Genetic Determinants of Ipilimumab Outcomes for Advanced Melanoma
Authors: T. Kirchhoff, C. Adaniel, J. Rendleman, E. Kern, N. Fleming, D. Polsky, R. Berman, R. Shapiro, Y. Shao, A. Heguy, I. Osman, A. Pavlick
Journal: Annals of Oncology (2014)
Immunisation registers – important for vaccinated individuals, vaccinators and public health
Authors: K Johansen, P L Lopalco, J Giesecke
Journal: Eurosurveillance (2012)

Preview this article: Immunisation registers – important for vaccinated individuals, vaccinators and public health, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/16/art20151-en-1.gif
Shear Wave Imaging of Passive Diastolic Myocardial Stiffness
Authors: Mathieu Pernot, Wei-Ning Lee, Alain Bel, Philippe Mateo, Mathieu Couade, Mickaël Tanter, Bertrand Crozatier, Emmanuel Messas
Journal: JACC. Cardiovascular imaging (2016)

The aim of this study was to investigate the potential of shear wave imaging (SWI), a novel ultrasound-based technique, to noninvasively quantify passive diastolic myocardial stiffness in an ovine model of ischemic cardiomyopathy. Evaluation of diastolic left ventricular function is critical for evaluation of heart failure and ischemic cardiomyopathy. Myocardial stiffness is known to be an important property for the evaluation of the diastolic myocardial function, but this parameter cannot be measured noninvasively by existing techniques. SWI was performed in vivo in open-chest procedures in 10 sheep. Ligation of a diagonal of the left anterior descending coronary artery was performed for 15 min (stunned group, n = 5) and 2 h (infarcted group, n = 5). Each procedure was followed by a 40-min reperfusion period. Diastolic myocardial stiffness was measured at rest, during ischemia, and after reperfusion by using noninvasive shear wave imaging. Simultaneously, end-diastolic left ventricular pressure and segmental strain were measured with a pressure catheter and sonomicrometers during transient vena caval occlusions to obtain gold standard evaluation of myocardial stiffness using end-diastolic strain-stress relationship (EDSSR). In both groups, the end-systolic circumferential strain was drastically reduced during ischemia (from 14.2 ± 1.2% to 1.3 ± 1.6% in the infarcted group and from 13.5 ± 3.0% to 1.9 ± 1.8% in the stunned group; p <0.01). SWI diastolic stiffness increased after 2 h of ischemia from 1.7 ± 0.4 to 6.2 ± 2.2 kPa (p < 0.05) and even more after reperfusion (12.1 ± 4.2 kPa; p < 0.01). Diastolic myocardial stiffening was confirmed by the exponential constant coefficient of the EDSSR, which increased from 8.8 ± 2.3 to 25.7 ± 9.5 (p < 0.01). In contrast, SWI diastolic stiffness was unchanged in the stunned group (2.3 ± 0.4 kPa vs 1.8 ± 0.3 kPa, p = NS) which was confirmed also by the exponential constant of EDSSR (9.7 ± 3.1 vs 10.2 ± 2.3, p = NS). Noninvasive SWI evaluation of diastolic myocardial stiffness can differentiate between stiff, noncompliant infarcted wall and softer wall containing stunned myocardium.
Cognitive style of patients with bulimic and diet-restricting anorexia nervosa
Authors: B B Toner, P E Garfinkel, D M Garner
Journal: American Journal of Psychiatry (1987)

Recent studies have reported that subjects with bulimic anorexia nervosa are more behaviorally impulsive than those with diet-restricting anorexia nervosa. This study found that bulimic anorexic patients made significantly more errors on the Matching Familiar Figures Test than restricting anorexic and comparison groups. This preliminary finding leads to the speculation that bulimic patients are more cognitively impulsive than restricting anorexic patients.
CR-03NUCHAL SKINFOLD THICKNESS: A NOVEL PARAMETER FOR ASSESSMENT OF BODY COMPOSITION IN CHILDHOOD CRANIOPHARYNGIOMA
Authors: Anthe S. Sterkenburg, Anika Hoffmann, Julia Reichel, Kristin Lohle, Maria Eveslage, Monika Warmuth-Metz, Hermann L. Müller
Journal: Neuro-Oncology (2016)
Abstract A16: The crosstalk between Indoleamine 2,3 Dioxygenase (IDO) and cancer stem cells in murine melanoma: A potential modality of local control
Authors: Marsha Kocherla, Blake Christianson, James Walker, Xu Qin, Jack C. Yu, Babak Baban
Journal: Cancer Research (2016)

Abstract Introduction: Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enzyme of tryptophan catabolism, has been strongly associated with the progression of malignancy and poor survival in melanoma patients. As a result, IDO is a leading target for interventions aimed at restoring melanoma immune surveillance. IDO, which is produced by cells including dendritic cells, macrophages, stem cells, and most tumor cells, potently suppresses immune responses by depleting local tryptophan and allowing the accumulation of tryptophan metabolites. However, the actual cellular and molecular mechanisms underlying the immunoregulatory function of IDO remain largely unknown. The relatively newly described cancer stem cells (CSCs) are tumor-initiating cells (TICs) that often survive therapy and give rise to second-line tumors by self-renewal and differentiation into multiple cell types. CSCs are proposed to persist in tumors as a distinct population and to cause relapse and metastasis by giving rise to new tumors. Therefore, development of specific therapies targeted at CSCs holds hope for improvement of survival and quality of life of cancer patients, especially those with metastatic disease. Methods: C57/BL6 mice were injected with B16F10 murine melanoma cell line (1 x 106 cells/mouse, subcutaneous). Tumor growth monitored. At 3mm, tumors were injected with an IDO Inhibitor (1 MT) (Group 1) twice weekly (20 mg/mouse per injection). Controls (Group 2) received vehicle only (PBS), Group 3 weekly Cisplatin (5mg/kg), and Group 4 both Cisplatin and 1MT (IDO inhibitor). Once the first tumor reached 12mm in size, the mice were sacrificed and tumor cells subjected to flow-cytometry, and statistical analysis, and p-values &amp;lt;0.05 considered significant. Results: Our data showed for the first time that IDO was expressed by CSCs in a murine melanoma model. These IDO-expressing CSCs may be capable of suppressing T lymphocyte infiltration into the tumor microenvironment, which was reversed by the IDO inhibitor, 1-methyl-tryptophan. Conclusion: Our findings offer an important new line of evidence that interventional targeting of IDO activity could be used to restore tumor immunity by relieving IDO-mediated immune suppression of CSCs in the tumor microenvironment as well as in tumor cells themselves. Citation Format: Marsha Kocherla, Blake Christianson, James Walker, Xu Qin, Jack C. Yu, Babak Baban. The crosstalk between Indoleamine 2,3 Dioxygenase (IDO) and cancer stem cells in murine melanoma: A potential modality of local control. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr A16.
Assessing Cutaneous Psoriasis Activity Using FDG-PET
Authors: Anshika Bakshi, Saeid Gholami, Abass Alavi, Joel M. Gelfand, Junko Takeshita
Journal: Clinical Nuclear Medicine (2015)

Psoriasis is a chronic inflammatory skin condition characterized by well-circumscribed erythematous plaques with thick silvery scale. Infiltration of inflammatory cells such as lymphocytes, neutrophils, and macrophages and epidermal cell proliferation within psoriatic lesions may result in selective FDG accumulation. We present a 55-year-old patient with a 30-year history of psoriasis. Nonattenuation corrected PET/CT images demonstrated significant cutaneous FDG uptake corresponding to clinically apparent psoriatic lesions. However, in attenuation corrected (AC) FDG-PET images, the signal was substantially diminished and minimally detectable. Nonattenuation corrected FDG-PET images may be useful and preferable to AC images in assessing skin inflammation in psoriasis.
Abstract IA12: Microfluidic isolation of circulating tumor cells and microvesicles from cancer patients
Authors: Shannon L. Stott
Journal: Cancer Research (2016)

Abstract Malignant tumors will aggressively invade surrounding tissue due to rapidly dividing cancer cells that are nourished by an ample blood supply. As these cancer cells are multiplying, they release thousands of tiny particles into the blood stream, referred to as exosomes and microvesicles, which contain genetic information about the tumor. Whole cancer cells are also released from the tumor and these rare circulating tumor cells (CTCs) provide genetic and functional information about the patient's cancer. Through a collaborative effort between bioengineers, biologists, and clinicians, our group at MGH has developed microfluidic devices to isolate both of these rare circulating biomarkers from whole blood. Data from these devices will be presented with a focus on our recent effort to characterize microvesicles and CTCs from patients with glioblastoma. Through the microfluidic isolation of blood based biomarkers from glioblastoma patients, our goal is to obtain complementary data to the current standard of care radiologic measurements to help better guide treatment for this deadly cancer. Citation Format: Shannon L. Stott. Microfluidic isolation of circulating tumor cells and microvesicles from cancer patients. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA12.
Prolonged Thrombocytopenia Is Associated With Increases Of CD8+ CX3CR1+ Cells In The Bone Marrow After Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Xiaohui Zhang, Guoxiang Wang, Honghu Zhu, Yanrong Liu, Daihong Liu, Lanping Xu, Wei Han, Huan Chen, Yuhong Chen, Feng-Rong Wang, Kaiyan Liu, Xiaojun Huang
Journal: Blood (2013)
Tuberculosis: story of medical failure
Authors: C. Holme
Journal: BMJ (1998)

<h3>Background</h3> National guidelines on the care of women requesting induced abortion recommend that counselling prior to termination of pregnancy (TOP) includes information about potential complications and sequelae. Case notes of women requesting TOP in a single hospital Trust were audited for documentation of counselling about complications. As a result of this audit the integrated care pathway (ICP) was altered to include a list of the potential complications and sequelae. We repeated the audit to evaluate the effect of this intervention on counselling. <h3>Objective</h3> To re-audit the counselling of women undergoing TOP with regard to the potential complications and sequelae of TOP and to compare counselling in consultant-led and nurse-led clinics. <h3>Methods</h3> The study population comprised women requesting TOP within south Glasgow, UK who were seen in a consultant-led gynaecology clinic or nurse-led clinic. A retrospective audit was carried out in 2004 and a prospective audit in 2005. Case notes and correspondence to primary care referrers were reviewed for documented evidence of counselling. <h3>Results</h3> We reviewed 98% of case notes in the first audit and 85% in the second audit. Results from both nurse-led and consultant-led clinics indicated that evidence of adequate counselling had improved, with an increase from 98% to 100% in the nurse-led clinics and from 43% to 64% in the consultant-led clinics. <h3>Conclusions</h3> Comparison of results from 2004 and 2005 suggests improvement in counselling since introduction of an ICP listing complications and sequelae of TOP.
Gene Expression Analysis and Immunohistochemistry in Evaluation of Cancer of Unknown Primary: Time for a Patient-Centered Approach
Authors: Charles R. Handorf
Journal: Journal of the National Comprehensive Cancer Network (2011)

Molecular medicine is rapidly changing the diagnosis and management of cancer of unknown primary. The science, business, and economics of the genomic revolution have moved at such a pace that coordinating practical application of all available tools, such as gene expression analysis and immunohistochemistry, often seems to clash. In fact, very little work has been done to actively coordinate use of these techniques, each of which can be very resource-intensive. The Institute of Medicine proposed the STEEEP principles, a basic set of guidelines that maintain that the best patient care is safe, timely, effective, efficient, equitable, and patient-centered. Application of these principles will help lead to a better understanding of the most appropriate use of modern diagnostic modalities.
Abstract A77: Validation of the EORTC QLQ-OV28 instrument for the assessment of quality of life in women with ovarian carcinoma in Mexico.
Authors: Dolores Gallardo-Rincon, Wendy Munoz-Montano, David Cantu de Leon, Jaime Coronel-Martinez, Flavia Morales, Luis F. Onate-Ocana.
Journal: Clinical Cancer Research (2016)

Abstract Objective: Health-related quality of life (HRQL) is an important outcome measurement in Oncology. Our aim was to validate the Mexican-Spanish version of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-OV28 questionnaire to assess HRQL in patients with Ovarian cancer (OC). Patients and Methods: The QLQ-C30 and QLQ-OV28 instruments were applied to Mexican patients with OC at a cancer referral centre. Reliability and validity tests were performed, and test-retest analysis was carried out in a subgroup of patients. Results: Two hundred fifty-two women were included in this cohort. Questionnaire compliance rates were high and the instrument was well accepted; internal consistency tests demonstrated good convergent and divergent validity. Cronbach's α; coefficients of 8 of 9 multi-item scales of the QLQ-C30 and of 6 of 8 scales of the QLQ-OV28 instruments were &amp;gt;0.7 (range, 0.22 to 0.89). Scales of the QLQ-C30 and QLQ-OV28 instruments distinguished among clinically distinct groups of patients; some were highly sensitive to change over time after the use of induction chemotherapy, and some were associated to overall survival. Conclusion: The Mexican-Spanish version of the QLQ-OV28 questionnaire is reliable and valid for the assessment of HRQL in patients with OC and can be broadly used in clinical trials. Citation Format: Dolores Gallardo-Rincon, Wendy Munoz-Montano, David Cantu de Leon, Jaime Coronel-Martinez, Flavia Morales, Luis F. Onate-Ocana. Validation of the EORTC QLQ-OV28 instrument for the assessment of quality of life in women with ovarian carcinoma in Mexico. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A77.
448 IL28B GENOTYPE IS NOT ASSOCIATED WITH INSULIN RESISTANCE IN CHRONIC HEPATITIS C PATIENTS
Authors: E. Degasperi, L. Valenti, A. Aghemo, R. De Francesco, R. Soffredini, R. D'Ambrosio, M. Rumi, L. Donnici, C. Cheroni, V. Zanoni, E. Orsi, M. Colombo
Journal: Journal of Hepatology (2013)