tbuckley/cabot-search huggingface dataset:
SP0135 From Small to Large Animal Models of Oa: Relevance to Clinical Practice
Authors: S. Mastbergen
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Osteoarthritis (OA) is a heterogeneous condition in which various symptoms culminate via different pathways in a common clinically characteristic pathology. The disease involves not only cartilage but the whole joint, including subchondral bone, synovial tissue, menisci (in the case of the knee), the capsule, ligaments, and muscles. OA slowly progresses and increases in prevalence and severity with age. To understand the complex inter-relationship between the different disease mechanisms, joint tissues, and body systems, studying OA in animal models is necessary. Numerous animal models of OA have been developed in lots of different species, including horses, sheep, dogs, rats, and mice. Several factors should be taken into account when choosing a specific model. This presentation addresses several of these aspects and describes the generally accepted smaller and larger animal models of OA and their translation to clinic practice. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6195
Efficacy of FDG PET/CT Imaging for Venous Thromboembolic Disorders
Authors: Søren Hess, Poul Henning Madsen, Else Dalsgaard Iversen, Jens Jørgen Frifelt, Poul Flemming Høilund-Carlsen, Abass Alavi
Journal: Clinical Nuclear Medicine (2014)

Purpose In recent years, several case reports have described venous thromboembolism (VTE) on FDG PET/CT. In this short communication, we present results from a proof-of-concept pilot study aimed at providing some preliminary data on the efficacy of FDG PET/CT in prospective patients with suspected VTE. Patients and Methods Fifteen patients with suspected deep venous thrombosis (DVT) and/or pulmonary embolism (PE) were included prospectively and underwent a whole-body FDG PET/CT. Patients were divided into 4 groups as follows: DVT+ (DVT proven by high clinical suspicion and positive compression ultrasound), DVT− (DVT ruled out by low clinical suspicion and negative compression ultrasound), PE+ (PE proven by high clinical suspicion and positive lung scintigraphy), and PE− (PE ruled out by low clinical suspicion and normal lung scintigraphy). Images were interpreted visually by 2 experienced nuclear medicine physicians independently and without knowledge of other imaging results. Results Seven DVT+, 6 DVT−, 6 PE+, and 1 PE− were included. Five patients were suspected of both DVT and PE. FDG PET/CT correctly diagnosed the presence or lack of DVT in all patients, whereas results are more ambiguous in PE with only 2 of 6 PE patients showing FDG avidity. The readers agreed in all cases. Conclusions Although further studies are warranted for further clarification, our preliminary data substantiate that FDG PET/CT is a viable modality for assessing VTE, at least for DVT. We believe our results add positively to the limited data on this subject and are promising enough to warrant further larger series.
Abstract LB-329: Defining rgulatory T-cells as CD4+CD25hiCD127- or as CD4+CD25hiFoxP3+ in immune monitoring of cancer vaccine clinical trials
Authors: Guy T. Clifton, Ritesh Patil, Kevin Clive, Josh Tyler, Athina Zacharia, Yusuf Jama, Mohamed Mursal, Kathy Ciano, Jarrod P. Holmes, Elizabeth A. Mittendorf, George E. Peoples, Sathibalan Ponniah
Journal: Cancer Research (2010)

Abstract Background: Regulatory T cells (Treg) are widely accepted to play a key role in the immune tolerance and escape of cancer cells. Originally Tregs were identified as being CD4+ T cells expressing high levels of CD25 (IL2 receptor). The identification of the transcription factor FoxP3 resulted in defining Tregs as CD4CD25hiFoxP3+ T cells by staining permeablized cells. Recently Tregs have been identified as CD4CD25hi T cells with low levels of CD127 (IL7 receptor) expressing a CD4+CD25hiCD127- cell surface phenotype. In an ongoing clinical trial with a MHC class II HER2/neu pep tide vaccine we have evaluated these various definitions of Treg phenotypes for immunological monitoring. Methods: Tregs were quantified in disease-free, high risk BCa patients enrolled in adjuvant peptide-based breast cancer vaccine trials. Peripheral blood mononuclear cells (PBMCs) were both permeabilized and stained with CD4, CD25, and FoxP3 monoclonal antibodies and surface stained with CD4, CD25, and CD127. Samples were then analyzed by flow cytometry. The means are compared with t-test and correlation is determined with Pearson's correlation coefficient. Results: 196 PBMC samples from 72 patients were available for Treg quantification. There was a greater mean percentage of cells identified as Treg in permeabilized than nonpermeabilized cells by staining with CD4+CD25hi (5.9±0.1% vs 4.8 ±0.1%, p&amp;lt;0.01) and excellent correlation between the tests (r=0.78, p&amp;lt;0.01). There was a greater mean percentage of cells identified as Tregs by CD4+CD25hi than CD4+CD25hiFoxP3+ (5.9±0.1% vs 3.6±0.1%, p&amp;lt;0.01) with good correlation (r=0.68, p&amp;lt;0.01). There was a greater mean percentage of Tregs by CD4+CD25+ than CD4+CD25+CD127- (4.8±0.1 vs 4.0±0.1, p&amp;lt;0.01) with excellent correlation (r=0.89, p&amp;lt;0.01). There was a greater mean percentage of Tregs by CD4+CD25hiCD127- than Tregs by CD4+ CD25hiFoxP3+ although levels were similar (4.0±0.1 vs 3.6±0.1, p&amp;lt;0.01) and the two tests had good correlation (r=0.58, p&amp;lt;0.01). Conclusion: There was good correlation between various methods of defining Tregs with and without cell membrane permeabilization. Defining Treg cells as either CD4+CD25hiFoxP3+ or CD4+CD25+CD127- appear to be more specific than defining Tregs as CD4+CD25hi alone. Furthermore, defining Treg populations by surface staining as CD4+CD25hiCD127- yields similar levels with good correlation as CD4+CD25hiFoxP3+ and may be the preferred method for immune monitoring. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-329.
Abdominal Wall Desmoid Fibromatosis Mimics Sarcoma With Intense FDG Uptake on FDG PET/CT
Authors: Feng Xu, Min-Ling Liu, Behram Pastakia, Frank Liu
Journal: Clinical Nuclear Medicine (2015)

We present the case of an abdominal wall soft tissue mass with intense FDG uptake in a 61-year-old man with unintentional weight loss. The appearance of this mass and high focal FDG uptake mimics high-grade sarcoma on 18F-FDG PET/CT. However, the final excisional histopathological diagnosis was desmoid fibromatosis.
HYPERTENSION REDUCES CORONARY FLOW RESERVE IN MEN AND WOMEN IN REGADENOSON PET/CT MYOCARDIAL BLOOD FLOW VALUES
Authors: Jordan A. Hess, Jason Allen, Steve Mason, JD Ethington, Jeffrey Anderson, Raymond McCubrey, Viet Le, Ritesh Dhar, Kent Meredith, Hannah Raasch
Journal: Journal of the American College of Cardiology (2015)
L' endomicroscopie confocale par minisonde au travers d'une aiguille pour le diagnostic des masses pancréatiques: critères préliminaires (étude CONTACT)
Authors: M Giovannini, F Caillol, D Lucidarme, B Pujol, F Poizat, G Monges, B Filoche, B Napoléon
Journal: Endoscopy (2014)

L'endomicroscopie confocale par minisonde au travers d'une aiguille (ECM) est une technique d'imagerie permettant de réaliser un examen microscopique in vivo et en temps réel, au cours d'une procédure d'échoendoscopie (EE) avec ponction, via une aiguille de ponction 19G. L'étude CONTACT (Clinical evaluation Of NCLE in The lymph nodes Along with masses and Cystic Tumors of the pancreas) a pour objectif d'établir un atlas d'image et d'identifier des critères d'interprétation pour la caractérisation des masses solides du pancréas.
Availability of Intravenous Quinidine for falciparum Malaria
Authors: Philip J. Rosenthal, Carolyn Petersen, Francesca R. Geertsma, Steve Kohl
Journal: New England Journal of Medicine (1996)

To the Editor: Intravenous quinidine, the treatment of choice for patients with life-threatening falciparum malaria, is no longer available at many hospitals. A four-year-old boy, born in the United States, was brought to San Francisco General Hospital in April 1996 after two days of fever, malaise, and watery diarrhea that began three weeks after his return from a three-week visit to Sierra Leone. He had not received malaria chemoprophylaxis. The child was intermittently somnolent and had an enlarged spleen. The hematocrit was 28.1 percent, the platelet count 71,000 per cubic millimeter, and the peripheral-blood smear showed that 8 to 10 . . .
1368 FURTHER VALIDATION OF TERMINAL PEPTIDE OF PROCOLLAGEN III (PIIINP) FOR THE DETECTION AND ASSESSMENT OF NONALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE
Authors: S. Tanwar, J. Parkes, P.M. Trembling, B.J. Hogan, D. Schuppan, M. Pinzani, M.J. Arthur, A. Burt, W.M. Rosenberg
Journal: Journal of Hepatology (2013)
Payment for Diabetes Care Under the Medicare Fee Schedule
Authors: Roz Diane Lasker
Journal: Diabetes Care (1992)

The system Medicare uses to determine physician payment is inequitable to physicians who provide primarily evaluation and management (EM) services. This creates financial incentives that may discourage physicians from providing Medicare patients with care that meets the American Diabetes Association's standards. Under Medicare's resource-based fee schedule, which will be phased in beginning January 1992, payment for EM services should more accurately reflect the time, effort, and overhead costs involved in providing them. This article describes how physician payment will be determined under the Medicare fee schedule and examines the probable effects of changes in payment on the physicians who care for patients with diabetes and the quality of services they provide.
Season of birth and autistic disorder in Israel
Authors: Y Barak, A Ring, J Sulkes, U Gabbay, A Elizur
Journal: American Journal of Psychiatry (1995)

Variations in month of birth were examined in patients with infantile autism to test the hypothesis that birth in a particular month may be a risk factor for this disorder.Data for autistic patients registered with the National League for Autism in Israel (N = 188) during the years 1964-1986 were compared with data on monthly distribution of live births in Israel for the corresponding period.After risk ratio estimates were computed for children born with infantile autism for each month, a significant increase was observed for children born in March and August. This association was true for each year throughout the study. An additional finding was a significantly higher rate of birth of autistic children in the years 1970-1976.This study, although made in a different climatic area than three earlier studies, further emphasizes the earlier findings that March and August births are a risk factor for development of autistic disorder.
Diffuse Soft-Tissue Calcinosis
Authors: Nauman Saleem Siddiqui, Nezam Altorok
Journal: New England Journal of Medicine (2015)

A 50-year-old-woman with dermatomyositis presented with progressive, diffuse subcutaneous nodules on the arms and legs. A radiograph of the left shoulder showed extensive soft-tissue calcification and an old fracture of the surgical neck of the humerus.
PWE-077 Access To A Faecal Calprotectin Service Provides Clinicians With The Confidence To Diagnose And Treat Concomitant Functional Bowel Symptoms In Known Ibd Patients
Authors: K Bundhoo, A Aravinthan, M Johnson
Journal: Gut (2014)

<h3>Introduction</h3> An accurate clinical assessment of disease activity in inflammatory bowel disease (IBD) is essential to provide appropriate management strategies. The concurrent presence of functional symptoms in IBD patients is common and said to occur in 80% of proctitis patients, 60% of UC patients and 40% of Crohn’s patients.<sup>1</sup> A high symptom index can strongly influence clinical assessment and expose patients to unnecessary investigations. Faecal calprotectin (FC) has a high negative predictive value of 96% for inflammation therefore allowing use in this cohort to differentiate functional and organic symptoms.<sup>2</sup> <h3>Methods</h3> All FC data over a 2 year period was collected in IBD outpatients with a diagnostic uncertainty about symptoms being functional or organic in nature and whether further endoscopic examination was necessary. FC results were regarded as normal (&lt;50 μg/g), borderline (50–100 μg/g) or positive (&gt;100 μg/g) and correlated with endoscopic assessment and subsequent influence on management. <h3>Results</h3> 262 FC measurements were performed in IBD patients where there was diagnostic uncertainty about symptoms being organic or functional in origin. In this cohort, unnecessary colonoscopy was spared in 83% (218/262), including 62/66 with normal FC, 26/27 borderlines and 130/169 positives. Despite a normal FC, 4 patients underwent further assessment via colonoscopy for routine surveillance with no evidence of active disease. In addition, some patients were investigated with CT colonography as an alternative assessment method. 0/2 scans in the borderline group showed positive findings with 6 being performed in the positive FC group. Of these, 5 had active disease with 1 showing a psoas abscess requiring inpatient treatment. As a result of a positive FC, a direct change in management was made in 114/169 (67%) without the need for further endoscopy. In the case of a negative FC result, 14/66 (21%) patients had an alteration in their treatment regimes to focus upon targeting functional bowel symptoms. <h3>Conclusion</h3> Faecal calprotectin measurement spared 80% of the colonoscopies being considered to assess symptomatic IBD patients. Both positive and negative results had a strong influence on subsequent management. FC measurement provides clinicians the confidence to isolate and manage functional symptoms in their IBD cohort, whilst preventing unnecessary treatment escalation. In those with a positive FC result, appropriate treatment could be initiated whilst avoiding the increased risks of endoscopy in acutely inflamed patients. <h3>References</h3> 1 Keohane, <i>et al</i>. <i>Am J Gastroenterol.</i> 2010 Aug;105(8):1788, 1789–94 2 Turvill, High negative predictive value of a normal faecal calprotectin in patients with symptomatic intestinal disease.<i> Frontline Gastroenterology</i> 2012;3:21–28 <h3>Disclosure of Interest</h3> None Declared.
IMPACT OF L-CARNITINE ON PLASMA LIPOPROTEIN(A) CONCENTRATIONS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Maria Corina Serban, Dimitri P. Mikhailidis, Peter Toth, Steven Jones, Paul Muntner, Michael Blaha, Florina Andrica, Seth Martin, Gregory Y.H. Lip, Kausik K. Ray, Maciej Banach
Journal: Journal of the American College of Cardiology (2016)
Abstract 767: The effects of triptolide on human breast cancer cells
Authors: Reginald Halaby, Michael Messina
Journal: Cancer Research (2010)

Abstract This research seeks to investigate how triptolide, an extract from the Chinese herb Tripterygium wilfordii Hook F, induces apoptosis in MCF-7 and SK-BR-3 human breast cancer cells. Triptolide is known to have anti-proliferative, anti-inflammatory, and anticancer properties. It has been used for over two centuries in Chinese medicine and is now used to treat certain autoimmune diseases. With breast cancer plaguing the United States as the second leading cause of cancer related deaths amongst women, as well as the adverse effects of current treatment methods to patients, there is a need for the development of safer and noninvasive treatments. Triptolide induces apoptosis in human breast cancer cells, but the exact mechanism is still largely unknown. In this study, we examined the ability of triptolide to regulate the protein expression levels of caspase-7 and caspase-9, PARP, and Bcl-2 via western analysis and the Pierce UnBlot In-Gel Chemiluminescent Detection Kit. Apoptosis was monitored using the MTT cell viability assay, LysoTracker™ staining, and measuring tumor volumes in nude mice bearing MCF-7 and SK-BR-3 xenograft tumors. Preliminary results indicate that the amount of apoptosis, which was significantly increased by triptolide in these cells, is both time- and dose-dependent, suggesting that there may be an optimal triptolide concentration for maximal anticancer efficacy. Triptolide differentially regulated the expression of pro- and anti-apoptotic proteins. Furthermore, triptolide decreased tumor volumes in vivo. Further investigation is warranted to determine if and how triptolide is activating the intrinsic apoptotic pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 767.
P48 An evaluation to understand the use of technology within a COPD population
Authors: M Gibb, V Willott, S Lohar, S Ward, C Bolton, P McAlinden, A De-Soyza, S Singh
Journal: Thorax (2013)

<h3>Introduction and Objectives</h3> There is a desire to employ technology to support patients with long term conditions. However there is little data available that describes familiarity with technology in the COPD population. We have an interest in developing alternative forms of pulmonary rehabilitation deploying technology. Therefore the aim of this evaluation was to understand the use of technology in this population. <h3>Methods</h3> Patients attending a consultant led COPD follow up clinic were asked to fill out a 10 itemed survey regarding their physical activity levels, if they had an interest in pulmonary rehabilitation and technological devices they may use. <h3>Results</h3> 191 patients returned the surveys, 168 from the Glenfield Hospital Leicester and 23 from the Newcastle upon Tyne Hospitals. The population surveyed consisted of 76 males, 81 females and 34 who did not specify their gender. The age range of population was; &lt;40 yrs 14 (8%); 40–50 yrs 18 (9.6%); 50–60 yrs 29 (15.5%); 60–70 yrs 61 (32.6%); 70–80 yrs 47 (25.1%); &gt; 80yrs 17 (9.1%). Within the total population it was found that 112 (60.5%) owned a computer and 138 (74.2%) own a mobile telephone however, of 138 only 22 (11.8%) were owners of a smart phone. Within each age range there were a small number of smart phone users but the predominant usage of smart phones occurred within the younger age ranges. Furthermore, within each age range a higher percentage of the population owned a mobile phone than those that did not. Similarly within each age range a higher percentage of the population owned a computer than did not, excluding the &gt;80 yrs, where 9 (52.9%) did not own a computer. <h3>Conclusion</h3> Overall the use of technology is limited in this COPD population. A significant proportion of those taking part used a mobile phone but a very small percentage used a smart phone, upon which a number of interventions might be delivered. Over half the population had a computer. There is a potential target market for providing alternative forms of pulmonary rehabilitation utilising technology, however, more evaluation is needed to ascertain whether a technological intervention would be acceptable to these patients.
Incidental Finding of Increased F-18 Fluorodeoxyglucose Uptake in the Vascular Graft of a Patient with a Solitary Pulmonary Nodule
Authors: D N Strauss, R K Halkar, V G Reddy, N P Alazraki
Journal: Clinical Nuclear Medicine (2001)

STRAUSS, DAVID N. M.D.*; HALKAR, RAGHUVEER K. M.D.‡; REDDY, VISHALA G. M.D.‡; ALAZRAKI, NAOMI P. M.D.† Author Information
Listeria Gastroenteritis — Old Syndrome, New Pathogen
Authors: Walter F. Schlech
Journal: New England Journal of Medicine (1997)

The evidence that Listeria monocytogenes can be a dangerous food-borne pathogen continues to accumulate. In this issue of the Journal, Dalton et al.1 provide evidence that this uncommon organism can be a cause of food poisoning. For most food-borne pathogens, such as salmonella and campylobacter species, gastrointestinal illness is the presenting and only symptom in the majority of cases. For L. monocytogenes, on the other hand, central nervous system infection and sepsis in the immunocompromised host have been the predominant clinical syndromes and were recognized long before transmission through food was suspected.The adult form of listeria meningoencephalitis bears a . . .
National Gonorrhea Therapy Monitoring Study
Authors: Harold W. Jaffe, James W. Biddle, Clyde Thornsberry, Robert E. Johnson, Richard E. Kaufman, Gladys H. Reynolds, Paul J. Wiesner
Journal: New England Journal of Medicine (1976)

To monitor temporal trends and regional differences in antibiotic susceptibility, we measured the minimum inhibitory concentrations for penicillin G, ampicillin, tetracycline, and spectinomycin of 4405 pre-treatment gonococcal isolates from patients with uncomplicated gonorrhea. As compared to isolates studied in 1970-1971, recent United States isolates appeared equally sensitive to penicillin G and more sensitive to tetracycline. Relatively resistant strains were found throughout the country. We also studied 1974 patients, treated for uncomplicated gonorrhea according to the 1972 regimens recommended by the United States Public Health Service, to determine the relation between pretreatment minimum inhibitory concentrations and treatment results. For patients receiving the procaine penicillin-probenecid and ampicillin-probenecid regimens, minimum inhibitory concentrations to the treatment drugs were significantly higher in patients not cured than in those cured (P less than 0.01 fr penicillin and P less than 0.05 for ampicillin). In contrast, spectinomycin-treatment results appeared to be independent of the isolate's susceptibility to spectinomycin and other antibiotics.
Complete Deficiency of Plasminogen-Activator Inhibitor Type 1 Due to a Frame-Shift Mutation
Authors: William P. Fay, Amy D. Shapiro, Judy L. Shih, Raymond R. Schleef, David Ginsburg
Journal: New England Journal of Medicine (1992)

THE process of plasminogen activation is considered a critical component of diverse biologic systems in humans. This reaction, which is catalyzed in vivo by tissue-type and urokinase-type plasminogen activators, results in the conversion of plasminogen to plasmin. Plasmin has an essential role in maintaining vascular patency by converting fibrin to soluble fibrin-degradation products. In addition, plasminogen activators have been implicated in the regulation of embryogenesis, angiogenesis, ovulation, inflammation, and tumor metastasis,1 suggesting that the plasminogen-activation system is an important mediator of tissue remodeling and cell migration. The activity of plasminogen activators is precisely regulated by several mechanisms.1 Critical among these . . .