tbuckley/cabot-search huggingface dataset:
P5 Quality Of Life and Functional Outcomes In Post-Transplant IPF Patients Aged Over 70
Authors: P Riddell, S Winward, K Redmond, JJ Egan
Journal: Thorax (2015)

<h3>Introduction</h3> In recent years there has been a large increase in rates of lung transplantation for IPF patients. This has driven by the introduction of the Lung Allocation Score in the US, which prioritises patients based on treatment need and benefit. Increasing rates of transplantation have led to older patients being considered for transplant listing. The aim of this study was to assess the survival, functional capacity and quality of life of IPF patients aged over 70 attending our transplant programme. <h3>Methods</h3> Post-transplant IPF patients aged 70 years or older were identified from the National Lung Transplant Registry. Health-related Quality of Life (HRQL) was assessed using the 36-item Medical Outcomes Survey Short Form (SF-36). Functional status was assessed by exercise tolerance, pulmonary function and level of respiratory support. HRQL was compared to published datasets from randomised clinical trials of drug therapy as well as prospective studies in lung transplant recipients. <h3>Results</h3> 6 patients met the inclusion criteria, mean age 72.5 ± 0.8 yrs. The mean time from transplant was 3.8 ± 1.5 yrs (range 2.3 – 7.0 yrs). Compared to the BUILD-1 trial (similar age, limited IPF), minimal important clinical differences (MID)<sup>1</sup> were seen across many components of the SF-36 score. These MIDs included physical functioning (+7.1), health perception (+29.2) and vitality (+17). Compared to a post-transplant cohort of younger IPF patients (61.0 ± 1.5 yrs)<sup>2</sup> the mental component score (MCS) was higher in this study (+12.2). These benefits in MCS were maintained when compared to patients in the IFIGENIA study of N-acetylcysteine and the STEP-IPF study of sildenafil. The mean reported exercise tolerance of our patient group was 1.2 km, and no patient required supplementary oxygen or respiratory support. Compared to pre-transplant status large benefits in function were noted (mean pre-transplant 6MWT was 314 ± 91 m with 6 L oxygen/minute). <h3>Conclusion</h3> Lung transplantation provides clinically meaningful benefits in HRQL and functional outcomes in patient’s ≥ 70 yrs old. This study highlights that these benefits are comparable to younger IPF patients who receive lung transplant and more beneficial to those reported in drug trials. <h3>References</h3> 1 <i>Respir Med</i>. 2010;<b>104</b>(2):296–304 2 <i>J Heart Lung Transplant</i>. 2014;<b>33</b>(5):514–520
Absence of Opening Click in Dehiscence of Mitral-Valve Prosthesis
Authors: Robert D. Leachman, Dennis V. P. Cokkinos
Journal: New England Journal of Medicine (1969)

Isolated absence of the opening click of the mitral disk-valve prosthesis was noted in six patients subsequently found to have suture disruption. Of five reoperated on, four survived. Angiocardiography was performed in two and demonstrated parabasilar leaks in both. This sign has hitherto been recognized only in thrombosis or swollen poppets of such prostheses. It is simple to detect and document by phonocardiography; it may be the only evidence of prosthetic valve dysfunction in a deteriorating patient since a murmur was heard in only two of six cases. It has not been found in any case in which the valve functioned normally. In suture disruption the valve is thought to "cock" abnormally because of inadequate support, so that blood flowing to the left ventricle partly flows through the dehiscence around the prosthesis and partly strikes the disk at an angle not exercising enough perpendicular force to open it abruptly and produce a click.
No Impact of Filaggrin Deficiency on Epit Efficacy in a Murine Model
Authors: Sophie Wavrin, Lucie Mondoulet, Vincent Dioszeghy, Emilie Puteaux, Mélanie Ligouis, Véronique Dhelft, Camille Plaquet, Christophe Dupont, Pierre-Henri Benhamou
Journal: Journal of Allergy and Clinical Immunology (2016)
Biochemical Profile of Uremic Breath
Authors: Michael L. Simenhoff, James F. Burke, Jussi J. Saukkonen, Anacleto T. Ordinario, Richard Doty, Stephen Dunn
Journal: New England Journal of Medicine (1977)

We attempted to define the substances that contribute to the characteristic "uremic breath" of patients with end-stage renal disease. Breath samples from nine patients underwent direct analysis before and after hemodialysis with use of gas chromatography and confirmation by mass spectrometry, and indirectly assessment by an organoleptic panel. Concentrations of secondary and tertiary amines, dimethylamine and trimethylamine were increased, with subsequent reduction after hemodialysis (dimethylamine from 2.00 +/- 0.19 [S.E.M.] to 0.88 +/- 0.12 microng per 30 minutes, P less than 0.001, and trimethylamine from 0.79 +/- 0.22 to 0.44 +/- 0.15 microng per 30 minutes, P less than 0.003). Treatment with nonabsorbable antibiotics in two patients reduced both serum and breath amine levels without dialysis. Loss of nitrogen via the breath was not quantitatively important. We conclude that uremic breath reflects the systemic accumulation of potentially toxic volatile metabolites, among which dimethylamine and trimethylamine have been positively identified and correlated with the classic fishy odor.
Radiotherapy with/without cisplatin following chemotherapy in limited small-cell lung cancer.
Authors: G V Scagliotti, A Gregor, G Giaccone
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.10.3479 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9779729 Radiotherapy with/without cisplatin following chemotherapy in limited small-cell lung cancer. G V ScagliottixG V ScagliottiSearch for articles by this author , A GregorxA GregorSearch for articles by this author , G GiacconexG GiacconeSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.10.3479 PDF "Radiotherapy with/without cisplatin following chemotherapy in limited small-cell lung cancer.." Journal of Clinical Oncology, 16(10), pp. 3479–3480© 1998 by American Society of Clinical Oncology
Hemolytic Uremic Syndrome in Families
Authors: Bernard S. Kaplan, Russell W. Chesney, Keith N. Drummond
Journal: New England Journal of Medicine (1975)

The occurrence of the hemolytic uremic syndrome in three siblings prompted us to study this illness in families. Two groups of patients could be identified when 83 siblings with the syndrome in 41 families were examined. Siblings whose onset occurred within a short time of each other had a relatively good prognosis (19 per cent mortality); those whose onset was more than a year apart had a poorer prognosis (68 per cent mortality). We speculate that an environmental agent may have caused the syndrome in the first group, and that genetic factors may have been important in the second.
Abstract 283: Nppa Marks A Subset Of Embryonic Cardiomyocytes Predestined To Form Trabeculae In Zebrafish
Authors: Rima Arnaout, Didier Y Stainier, Shaun R Coughlin
Journal: Circulation Research (2014)

The development and maintenance of cardiac trabeculae is required for proper ventricular function. Aberrant trabeculation can cause heart failure, arrhythmia, and death. Yet the mechanisms controlling initiation of trabeculation are incompletely understood, partly due to a lack of markers for trabeculation during early embryogenesis. We hypothesized that natriuretic peptide A (nppa) marks trabeculae before cardiomyocytes leave the single-celled ventricular layer. While nppa has been studied in mammals, the external development of the translucent zebrafish embryo offers new insight into the earliest stages of trabeculation. We have found by in situ hybridization, and by creating a fluorescent transgenic zebrafish line, that nppa exclusively marks zebrafish cardiac trabeculae from their onset through adulthood. Live spinning disc confocal video microscopy shows that nppa:GFP-positive cells move into the trabecular layer starting at 60 hours post fertilization (hpf). GFP-positive trabeculae are seen by 5 days post fertilization (dpf) in normal larvae. However, in cardiac troponin T2a mutants and in erbB2 mutants _ both known not to trabeculate _ nppa is still expressed, but the nppa:GFP positive cells fail to form trabecular projections. In embryos injected with a morpholino against atrial myosin heavy chain 6, where weakened atrial contraction leads to weaker blood flow without affecting the ventricle directly, GFP-positive cells form trabeculae similar to uninjected controls. Using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs), we created nppa mutants causing frameshift deletions. Mutants have poorly contractile hearts at 3 dpf and have been crossed into transgenic reporter lines in order to specifically assess trabeculation. Together, these data suggest that nppa marks a subset of embryonic cardiomyocytes destined to form trabeculae, and that nppa loss of function causes cardiac defects.
Methotrexate dosage as a source of bias in biological trials in rheumatoid arthritis: a systematic review
Authors: Josefina Durán, Margarita Bockorny, Deepan Dalal, Michael LaValley, David T Felson
Journal: Annals of the Rheumatic Diseases (2016)

To evaluate if optimal dose of either oral or injectable regimens of methotrexate (MTX) of 25 mg/week was used in the comparator arms of studies comparing biologic drugs with MTX in rheumatoid arthritis (RA). A systematic literature search was carried out in MEDLINE, EMBASE and the Cochrane Library databases for randomised controlled trials comparing biologics with MTX in RA. A systematic review was performed among studies that met predefined criteria focusing on assessment of dose of MTX used in the comparator arm. Study authors were contacted when necessary. Study quality was assessed. A total of 3276 references were identified and 13 trials were included. We obtained maximal dose and regimen for all. The maximal dose of MTX used in the comparator arm of the trials was no more than 20 mg/week in any trial and for all but one trial, MTX was given orally and not by injection. The trial that used an injectable form reached a maximum of 15 mg/week. A suboptimal dose of MTX was used in biological clinical trials performed in RA, particularly regarding route of administration. This may have biased findings in favour of biological agents.
Effect of Early or Delayed Insertion of Tympanostomy Tubes for Persistent Otitis Media on Developmental Outcomes at the Age of Three Years
Authors: Jack L. Paradise, Heidi M. Feldman, Thomas F. Campbell, Christine A. Dollaghan, D. Kathleen Colborn, Beverly S. Bernard, Howard E. Rockette, Janine E. Janosky, Dayna L. Pitcairn, Diane L. Sabo, Marcia Kurs-Lasky, Clyde G. Smith
Journal: New England Journal of Medicine (2001)

A main indication for the insertion of tympanostomy tubes in infants and young children is persistent otitis media with effusion, reflecting concern that this condition may cause lasting impairments of speech, language, cognitive, and psychosocial development. However, evidence of such relations is inconclusive, and evidence is lacking that the insertion of tympanostomy tubes prevents developmental impairment.
National Health Service — Recommendations of the Hoover Commission
Authors: Hugh R. Leavell
Journal: New England Journal of Medicine (1949)

FORMATION of the Commission on Organization of the Executive Branch of the Government, more widely known as the Hoover Commission, was authorized by the eightieth Congress. Its duties were to investigate activities of the Executive Branch with the objectives of limiting expenditures as far as possible consistent with proper performance of essential services; doing away with overlapping and duplication; consolidating similar services and abolishing unnecessary ones; and defining the limits of executive function. The President appointed four members of the Commission; four were appointed by the President of the Senate, and four by the Speaker of the House of Representatives. . . .
Case 32-2005
Authors: Laura E. Riley, Sigal Yawetz
Journal: New England Journal of Medicine (2005)

A 34-year-old woman who had had asymptomatic human immunodeficiency virus (HIV) infection for nine years desired to become pregnant. She had stable CD4 T-cell counts without antiretroviral therapy. She had a history of human papillomavirus infection and cervical dysplasia. An obstetrician and a specialist in infectious diseases discuss the management of HIV infection and pregnancy.
Diverticulosis and Acute Diverticulitis of the Jejunum
Authors: John W. Ratcliffe, Marshall K. Bartlett, James A. Halsted
Journal: New England Journal of Medicine (1950)

OUR interest in diverticulosis and diverticulitis of the jejunum was stimulated recently by the unexpected finding at laparotomy of such a case. A review of the records of the Faulkner Hospital from 1937 to 1949 reveals only 1 similar case. Because of the extreme rarity of this condition, these cases are reported below.IncidenceJejunal diverticulosis is an uncommon finding. Edwards1 described 5 cases in 881 autopsies — an incidence of 0.57 per cent. Browne and McHardy, according to Jones,2 reported 16 cases in nearly 8000 autopsies. Roentgenologic study of the gastrointestinal tract has been a less sensitive indicator of . . .
Palliative chemotherapy and cancer-related fatigue in advanced NSCLC patients
Authors: C. S. Cleeland, Q. Shi, C. Lu, V. Johenson, T. Mendoza, L. Palos, G. Mobley, X. Wang
Journal: Journal of Clinical Oncology (2007)

6622 Background: Cancer-related fatigue is one the most severe and prevalent symptoms in patients with advanced-stage non- small cell lung cancer (NSCLC). Whether palliative chemotherapy causes additional fatigue, beyond that which is caused by the disease itself, is unknown. Methods: Study subjects were 88 patients with advanced NSCLC who were treated with platinum-based chemotherapy at The University of Texas M. D. Anderson Cancer Center. Fatigue severity and other symptoms were measured weekly using the 0–10 rating scales of the M. D. Anderson Symptom Inventory (MDASI). Using mixed-effect modeling, we assessed fatigue severity over time of receiving chemotherapy. Results: Over the time of this longitudinal symptom assessment study, fatigue severity was overwhelmingly higher than all other symptoms. We observed no significant impact on fatigue severity by age, sex, or race/ethnicity variation; however, there was a significant difference in fatigue severity using longitudinal analysis between patients who discontinued chemotherapy within 0–6 week vs beyond 12 weeks (P&lt;.05), and within 6–12 weeks vs beyond 12 weeks (P&lt;0.01). By each cycle of chemotherapy, the fatigue pattern showed a consistent trend of reduced severity at day 0–3, a fatigue peak on day 5–6 (P&lt;.05), then unchanged during days 7–21. Fatigue was most severe during the first cycle. Discussion: Cancer-related fatigue was the most severe symptom in the study sample, especially for patients only able to receive 2–4 cycles of chemotherapy. However, patients who received over 4 cycles of chemotherapy had a stable level of fatigue, which indicates that continued chemotherapy does not increase fatigue. Additional analysis demonstrated that fatigue was at it's lowest immediately following chemotherapy, possibly related to the use of steroids in conjunction with chemotherapy administration. No significant financial relationships to disclose.
Advanced phase I/II evaluation of tumor-targeted gene delivery: Intravenous retrovector encoding mutant anticyclin G1 as stand-alone therapy for chemotherapy-resistant bone and soft tissue sarcoma.
Authors: K. N. Ganjoo, S. P. Chawla, V. S. Chua, L. Fernandez, D. V. Quon, A. Saralou, F. L. Hall, E. M. Gordon
Journal: Journal of Clinical Oncology (2010)

10010
Case 18-2003
Authors: Leslie E. Lehmann, Sudha Anupindi, Nancy Lee Harris
Journal: New England Journal of Medicine (2003)

Presentation of CaseA 15-year-old girl was admitted to the hospital because of pain in the left leg and back, pruritus, thoracic lymphadenopathy, and multiple pulmonary nodules.The patient had been well until 11 months earlier, when she began to be awakened during the night by pain in the left hip, which lasted an hour or two on each occasion. Several months later, pain developed in the lower back, and she ascribed it to competitive horseback riding. Five months before admission, she began to have bitemporal headaches, which were most severe in the afternoon and were sometimes accompanied by photophobia. . . .
Single-cell analysis of long non-coding RNAs in the developing human neocortex
Authors: Siyuan John Liu, Tomasz J. Nowakowski, Alex A. Pollen, Jan H. Lui, Max A. Horlbeck, Frank J. Attenello, Daniel He, Jonathan S. Weissman, Arnold R. Kriegstein, Aaron A. Diaz, Daniel A. Lim
Journal: Genome biology (2016)

Long non-coding RNAs (lncRNAs) comprise a diverse class of transcripts that can regulate molecular and cellular processes in brain development and disease. LncRNAs exhibit cell type- and tissue-specific expression, but little is known about the expression and function of lncRNAs in the developing human brain. Furthermore, it has been unclear whether lncRNAs are highly expressed in subsets of cells within tissues, despite appearing lowly expressed in bulk populations. We use strand-specific RNA-seq to deeply profile lncRNAs from polyadenylated and total RNA obtained from human neocortex at different stages of development, and we apply this reference to analyze the transcriptomes of single cells. While lncRNAs are generally detected at low levels in bulk tissues, single-cell transcriptomics of hundreds of neocortex cells reveal that many lncRNAs are abundantly expressed in individual cells and are cell type-specific. Notably, LOC646329 is a lncRNA enriched in single radial glia cells but is detected at low abundance in tissues. CRISPRi knockdown of LOC646329 indicates that this lncRNA regulates cell proliferation. The discrete and abundant expression of lncRNAs among individual cells has important implications for both their biological function and utility for distinguishing neural cell types.
Virus of Avian Myeloblastosis. XX. Amino Acid Composition<xref ref-type="fn" rid="fn1">2</xref>
Authors: Robert H. Purcell, R. A. Bonar, Dorothy Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1962)

The amino acid composition of the BAI strain A avian myeloblastosis virus was determined qualitatively by paper chromatography and quantitatively by ion exchange chromatography. The values found were reproducible with different preparations of virus and differed from those reported by others for three other viruses: influenza, rabbit papillomatosis, and tobacco mosaic. The BAI strain A virus contained glucosamine in the amount of 1.4 moles percent of total nitrogen.
Pyoderma gangrenosum and its syndromic forms: evidence for a link with autoinflammation
Authors: A.V. Marzano, A. Borghi, P.L. Meroni, M. Cugno
Journal: British Journal of Dermatology (2016)

Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis manifesting as painful ulcers with violaceous, undermined borders on the lower extremities. It may occur in the context of classic syndromes like PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) and SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis), as well as in a recently described entity named PASH (pyoderma gangrenosum, acne and suppurative hidradenitis). Pyoderma gangrenosum has recently been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation, without circulating autoantibodies and autoreactive T cells. In PAPA syndrome, different mutations involving the PSTPIP1 gene, via an increased binding affinity to pyrin, induce the assembly of inflammasomes. These are molecular platforms involved in the activation of caspase 1, a protease that cleaves inactive prointerleukin (pro-IL)-1β to its active isoform IL-1β. The overproduction of IL-1β triggers the release of a number of proinflammatory cytokines and chemokines, which are responsible for the recruitment and activation of neutrophils, leading to neutrophil-mediated inflammation. In SAPHO syndrome, the activation of the PSTPIP2 inflammasome has been suggested to play a role in inducing the dysfunction of the innate immune system. Patients with PASH have recently been reported to present alterations of genes involved in well-known autoinflammatory diseases, such as PSTPIP1, MEFV, NOD2 and NLRP3. Pyoderma gangrenosum and its syndromic forms can be regarded as a single clinicopathological spectrum in the context of autoinflammation.
Case 1-1992
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, S.E. Weinberger, E.J. Mark
Journal: New England Journal of Medicine (1992)

Presentation of Case First admission. A 34-year-old woman was admitted to the hospital because of a pruritic rash, cough, myalgia, and low-grade fever.The patient was well until one month earlier, when she began to experience an "ache" in the interscapular area. Four days before admission a sore throat developed, with enlarged cervical lymph nodes, a mild cough, exertional dyspnea, itching of the eyes, photophobia, and nausea. Three days later she noticed a small scaling pruritic patch on the right wrist that spread to involve the abdomen, thorax, and back, sparing the palms and lower extremities. She experienced a . . .
P263 Does age influence the diagnostic pathway in patients with TB lymphadenitis?
Authors: K Dave, A Saigal, F Ullah, F Miah
Journal: Thorax (2015)

<h3>Introduction</h3> London has a high incidence of TB with north-east London having amongst the highest rates of TB in the U. K. Microbiological analysis is the gold standard method of diagnosis for patients with TB. A recent review of patients with TB lymphadenitis demonstrated that a significant proportion of these patients were diagnosed on histology alone. This proportion increased in patients over 60 years old, suggesting that tissue or fluid specimens were not routinely analysed in this group. <h3>Aims</h3> To ascertain whether age is a factor in influencing the diagnostic pathway, particularly the use of invasive tests, in investigating individuals with lymphadenopathy in this high-incidence area for TB. <h3>Methods</h3> A retrospective analysis was undertaken of patients with TB lymphadenitis from 2009 – 2011 diagnosed by the Barking, Havering and Redbridge Hospitals NHS Trust TB service using the London TB register. <h3>Results</h3> 308 patients over the age of 18 years were identified with TB lymphadenitis. Of 281 patients between 18 – 65 years, 15.3% (43) had no specimen sent for analysis. 2/27 (7.4%) of patients &gt;65 years had no specimen sent for analysis. <h3>Conclusion</h3> Previous work has shown that in individuals over 60 years old, TB lymphdenitis was diagnosed predominantly on histology only (80%). Younger patients were more likely to have diagnosis confirmed on microbiology. This study demonstrates that increasing age is not a factor in influencing the diagnostic pathway, particularly the use of invasive tests, in investigating patients with lymphadenitis. However, in spite of the high incidence of TB, the biopsy specimens obtained from patients from all age groups are not routinely sent for microbiological analysis.