tbuckley/cabot-search huggingface dataset:
SAT0326 Effects of IL-1β (Canacinumab) and Betametazone on Glucose Metabolism and Pro-Inflammatory Cytokine Levels in Patients with Gout
Authors: M. Eliseev, O.V. Zhelyabina, A.S. Vladimirov, A.A. Novikov, E.N. Aleksandrova, E.L. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Prevalence of DM in patients with gout is high, but the influence of glucocorticoids (GC) and inhibitors IL-1β on their carbohydrate metabolism has not been investigated thoroughly. Anti-inflammatory effects connected with IL-1 inhibition are supposed to decrease the risk of DM [1]. <h3>Objectives</h3> To compare the effects of a single injection of canacinumab or betametazone on glucose metabolism and pro-inflammatory cytokine serum levels in patients with gout. <h3>Methods</h3> Open-label prospective randomized study of 40 patients with gout (37 m, 3 f), mean age 51,3±11,3 years, was performed. Inclusion criteria: crystal-proven gout, acute arthritis. Exclusion criteria: infections, sub- or decompensation of DM and use of anti-diabetic drugs. 20 patients received one dose of canakinumab 150 mg subcutaneously, 20 patients received one dose of betametazone 7 mg intraarticular. Basal and postprandial glucose (PPG) level was performed 120 min before injection and 24, 48 h and 14, 90 days after injection. Cytokine level was detected using of "xMAP" technology (Human Grp I Cytokine 27-plex panel) and on the analyzer "BioPlex-200" (Bio-Rad, the USA) before injection and 14 and 90 days after injection. Glycosylated hemoglobin (HbA1c) was determined by borate affinity assay. <h3>Results</h3> At baseline, glycemic levels (basal, PPG), HbA1c and cytokines in both groups were identical. Glycemic level ≥6,1 mmol/l and or PPG ≥11,1 mmol/l was detected in all patients injected betametazone in 24 hours, in 6 patients in 48 hours, in 4 patients in 14 days and in 3 patients in 90 days after the injection. There were no patients in study who were injected canacinumab with glycemic level ≥6,1 mmol/l and/or PPG ≥11,1 mmol/l. HbA1c level in a betametazone group in 90 days increased (from 5,83±0,49% to 6,01±0,60%), and on the contrary, in a canacinumab group decreased (from 5,75±0,55% to 5,61±0,50%), but the difference was not accurate. In a canacinumab group serum levels of IL-1β and IL-6 positively decreased on 14th and 90th days of study. Serum level of other cytokines in groups during the study did not change fundamentally. <h3>Conclusions</h3> In patients with gout who take intraarticular injections of GC, the risk of DM progression can be underestimated. In contrast, canacinumab taking can be connected with decreasing the risk of DM through the influence on the levels of IL-1β and IL-6. To study the influence of the medicines on carbohydrate metabolism further research is needed. <h3>References</h3> Noe A., Howard C., Thuren T. and al. Pharmacokinetic and Pharmacodynamic Characteristics of Single-dose Canakinumab in Patients With Type 2 Diabetes Mellitus. Clin Ther. 2014;36(11):1625-37. <h3>Disclosure of Interest</h3> None declared
Combination Treatment for COPD
Authors: Rebecca Voelker
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Confidentiality of medical records.
Authors: R Newcombe
Journal: BMJ (1978)

An Inter-Professional Working Group on Access to Personal Health Information in Great Britain has drawn up a draft code intended to safeguard the confidentiality of patients' medical records. The code, which is being circulated to health authorities and consumer groups for comment, permits disclosure without the patient's and/or health professional's consent in seven situations involving public health, national security, biomedical research, court order, statute, law enforcement, or complaints against health professionals or authorities. Passage of the 1984 Data Protection Act had left many health professionals concerned about unauthorizied access to medical information, and the Working Group and its code represent attempts on the part of the government to answer that concern.
P-227 Cordycepin inhibits lipopolysaccharide-induced cell migration and invasion in human colorectal carcinoma HCT116 cells through down-regulation of prostaglandin E2 receptor EP4
Authors: Y.H. Choi, J.-W. Jeong, M.H. Han, C. Park, Y.H. Yoo
Journal: Annals of Oncology (2015)
Mechanically resilient, injectable, and bioadhesive supramolecular gelatin hydrogels crosslinked by weak host-guest interactions assist cell infiltration and in situ tissue regeneration
Authors: Qian Feng, Kongchang Wei, Sien Lin, Zhen Xu, Yuxin Sun, Peng Shi, Gang Li, Liming Bian
Journal: Biomaterials (2016)
Evaluation of an Elementary School–based Educational Intervention for Reducing Arsenic Exposure in Bangladesh
Authors: Khalid Khan, Ershad Ahmed, Pam Factor-Litvak, Xinhua Liu, Abu B. Siddique, Gail A. Wasserman, Vesna Slavkovich, Diane Levy, Jacob L. Mey, Alexander van Geen, Joseph H. Graziano
Journal: Environmental Health Perspectives (2015)

Chronic exposure to well water arsenic (As) remains a major rural health challenge in Bangladesh and some other developing countries. Many mitigation programs have been implemented to reduce As exposure, although evaluation studies for these efforts are rare in the literature.In this study we estimated associations between a school-based intervention and various outcome measures of As mitigation.We recruited 840 children from 14 elementary schools in Araihazar, Bangladesh. Teachers from 7 schools were trained on an As education curriculum, whereas the remaining 7 schools without any training formed the control group. Surveys, knowledge tests, and well-water testing were conducted on 773 children both at baseline and postintervention follow-up. Urine samples were collected from 210 children from 4 intervention schools and the same number of children from 4 control schools. One low-As (< 10 μg/L) community well in each study village was ensured during an 18-month intervention period.After adjustment for the availability of low-As wells and other sociodemographic confounders, children receiving the intervention were five times more likely to switch from high- to low-As wells (p < 0.001). We also observed a significant decline of urinary arsenic (UAs) (p = < 0.001) (estimated β = -214.9; 95% CI: -301.1, -128.7 μg/g creatinine) among the children who were initially drinking from high-As wells (> Bangladesh standard of 50 μg/L) and significantly improved As knowledge attributable to the intervention after controlling for potential confounders.These findings offer strong evidence that school-based intervention can effectively reduce As exposure in Bangladesh by motivating teachers, children, and parents.
Iron pigment in the brain of a man with tardive dyskinesia
Authors: W G Campbell, M A Raskind, T Gordon, C M Shaw
Journal: American Journal of Psychiatry (1985)

A 64-year-old man with bipolar affective disorder developed persistent tardive dyskinesia following an overdose of lithium and haloperidol. Two years later he died of unknown causes. Neuropathologic examination revealed extensive deposition of iron in basal ganglia and substantia nigra.
Case 31-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Juan J. Canoso, Robert Fienberg
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 51-year-old man was admitted to the hospital because of fever, rash, and pains in the lower extremities.He was in excellent health until six weeks earlier, when he experienced a tick bite on the coast of Massachusetts. Soon thereafter he became febrile and fatigued, with edema and pain in the lower extremities. A physician obtained an echocardiographic study, which showed no abnormality; a serologic test for Lyme disease and two blood cultures were negative. Tetracycline, hydrochlorothiazide, ibuprofen, and propoxyphene–acetaminophen were prescribed, without relief of symptoms. Sixteen days before entry the patient came to this hospital. Examination . . .
PWE-296 How adequate is the information provided on histopathology request forms for colorectal cancer resection?
Authors: C Ntala, A Gumber, G Kaur
Journal: Gut (2015)

<h3>Introduction</h3> Surgical pathology depends heavily on the input of clinicians and surgeons. The pathologist’s need for adequate clinical information before diagnosis can be made has been highlighted in the past. According to the Royal College of Pathologists’ guidelines for reporting colorectal cancer, histopathology requests need (1) a diagram of the surgical procedure, (2) if the cancer has been detected as part of the bowel cancer screening programme, (3) the histological type of tumour if known, (4) a history of inflammatory bowel disease/ familial cancer, (5) the pre-operative stage of tumour, (6) any pre-operative therapy has been given, when it finished and its nature, (7) if open, laparoscopic or robotic surgery has been performed, the type and dissection plane of the operation. We aimed to audit the quality of clinical information provided in colorectal cancer resection histology requests for the past 5 years in our hospital. <h3>Method</h3> Data was collected for 500 patients with large bowel cancer resections between 2/12/2009 and 18/11/2014 <h3>Results</h3> Of 498 histology request forms, only two had a diagram present (0.4%) and three (0.6%) reported that the tumour was detected in the bowel cancer screening programme. The histological type was reported in 72 out of 496 samples (14.52%) and the presence of IBD or familial cancer was reported in 2 out of 497(0.4%). The pre-operative stage of tumour was recorded in 27 out of 496 reports (5.4%) and the pre-operative therapy given in 56 out of 496(11.3%). Finally, the type of surgery and dissection were adequately documented in 221 out of 497 reports (44.5%). <h3>Conclusion</h3> Overall, the quality of reporting of clinical information in histology reports remains suboptimal. This audit identified important areas in which reporting quality needs to be improved. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Dataset for colorectal cancer histopathology reports July 2014, Royal College of Pathologists guidelines Are clinicians failing to supply adequate information when requesting a histopathological investigation? J Clin Pathol. 2001;54(10):806
Free psychotherapy: an inquiry into resistance
Authors: J L Nash, J O Cavenar
Journal: American Journal of Psychiatry (1976)

Psychotherapy for which the patient is not charged, such as that provided by the Veterans Administration system, can lead to unique conflicts and resistances within treatment. Patients may depreciate the value of therapy, feel obligated to the therapist, or expect him to make inappropriate nonfinancial demands. The authors present five cases illustrating that lack of a fee may become the focus of insoluble resistances to therapy, and suggest that, particularly in training situations, a token fee should be charged to obviate these difficulties.
THU0203 Nsaids Administration in Patients with Axial SPA in Clinical Remission with Biologics
Authors: D.K. Patrikos
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Co treatment of NSAIDs with TnFα inhibitors (TnFi) in patients with early active Axial SpA was associated with increased levels of remission (INFAST trial) <h3>Objectives</h3> To investigate any effects of the addition of NSAIDs in patients with Axial SpA in remission with TnFi. <h3>Methods</h3> 40 patients with AxSpA (28 with Ankylosing Spondylarthritis (AS), 9 with Psoriatic Axial SpA (PsAS) and 3 with Inflammatory Bowel Disease Axial SpA (IBDAS) 32 men, 8 women with mean age 40,8±13,29, with mean disease duration 12,46 years ±11,8 all under anti TnFa Inhibitor treatment (Adalimumab n=9, Etanercept n=7, Golimumab n=10, Infliximab n=14) in clinical remission, with BASDAI &lt;4 and ASDAS<sub>TKE</sub> &lt; 2,1 before NSAIDs administration. We decided to add etoricoxib 90mg n=23 or Indomethacin 150 mg n=17 in a non randomized trial for a period of 1 month when we reassessed all clinical and laboratory indices ESR, CRP, BASDAI and ASDAS<sub>ESR.</sub> <h3>Results</h3> All patients were tolerated NSAIDs well, with no serious adverse events. Most of them had developed significant improvement in the clinical parameters of BASDAI and ASDAS<sub>ESR</sub> indices. Mean BASDAI at the beginning was 2,33 and ASDAS 1,99. After the addition of NSAIDs the mean values decreased to 0,93 and 1,46 respectively, differences statistically significant p&lt;0,0001. The most significant improvement was noticed in the second question of the BASDAI index and was associated with neck pain, where many patients, especially those with advanced disease, don9t respond adequately to TnFi. There were no differences in the levels of inflammation indices. <h3>Conclusions</h3> The addition of NSAIDs in patients with AxSpA in clinical remission with TnFi treatment, promoted significant improvement in parameters such as pain and stiffness. In our opinion bigger trials (number of patient and duration) with co-estimation of imaging findings will be useful to determine the position of NSAIDs in the treatment of patients with AxSpA. <h3>References</h3> Sieper J et al. Ann Rheum Dis. 2014 Jan;73(1):101-7 <h3>Disclosure of Interest</h3> None declared
Radiosurgery for malignant brain tumors.
Authors: P H Gutin, C B Wilson
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.4.571 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2179475 Radiosurgery for malignant brain tumors. P H GutinxP H GutinSearch for articles by this author , C B WilsonxC B WilsonSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.4.571 First Page PDF © 1990 by American Society of Clinical Oncology
Eosinophilia and fluid retention in systemic administration of interleukin-2.
Authors: J S Kovach, G J Gleich
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.5.815 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3486257 Eosinophilia and fluid retention in systemic administration of interleukin-2. J S KovachxJ S KovachSearch for articles by this author , G J GleichxG J GleichSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.5.815 PDF "Eosinophilia and fluid retention in systemic administration of interleukin-2.." Journal of Clinical Oncology, 4(5), pp. 815–816© 1986 by American Society of Clinical Oncology
What does research reproducibility mean?
Authors: Steven N. Goodman, Daniele Fanelli, John P. A. Ioannidis
Journal: Science Translational Medicine (2016)

The language and conceptual framework of "research reproducibility" are nonstandard and unsettled across the sciences. In this Perspective, we review an array of explicit and implicit definitions of reproducibility and related terminology, and discuss how to avoid potential misunderstandings when these terms are used as a surrogate for "truth."
Humidifier-associated paediatric Legionnaires' disease, Israel, February 2012
Authors: J Moran-Gilad, T Lazarovitch, M Mentasti, T Harrison, M Weinberger, Y Mordish, Z Mor, T Stocki, E Anis, C Sadik, Z Amitai, I Grotto
Journal: Eurosurveillance (2012)

We report a fatal case of community-acquired Legionnaires' disease in an infant aged under six months. Epidemiological and microbiological investigations suggested that a free-standing cold water humidifier using domestic tap water contaminated with Legionella pneumophila serogroup 1 served as a vehicle for infection. These findings were corroborated by sequence-based typing (SBT). Humidifier-associated Legionnaires' disease can be prevented by appropriate control measures. This case also illustrates the emerging role of SBT in the investigation of legionellosis.
Interrelation of Specific Genes, Body Weight, and Development of Tumors in Mice
Authors: W. E. Heston, Margaret K. Deringer, Ina R. Hughes, Jerome Cornfield
Journal: JNCI Journal of the National Cancer Institute (1952)

Interrelation of Specific Genes, Body Weight, and Development of Tumors in Mice Get access W. E. Heston, W. E. Heston National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer, Margaret K. Deringer National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ina R. Hughes, Ina R. Hughes National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jerome Cornfield Jerome Cornfield National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 5, April 1952, Pages 1141–1157, https://doi.org/10.1093/jnci/12.5.1141 Published: 01 April 1952 Article history Received: 11 February 1952 Published: 01 April 1952
Pathogenicity of Rous Sarcoma Virus for Rats and Rabbits&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: L A ZILBER
Journal: JNCI Journal of the National Cancer Institute (1961)

Inoculation of Rous sarcoma virus into rat embryos or newborn rats caused a hemorrhagic disease characterized by formation of cysts which filled with serous transudate and then became hemorrhagic. Subsequently, sarcomas appeared in some rats. In newborn rabbits the inoculation brought about a disease characterized by development of mostly benign multiple fibrous nodules from which the virus could sometimes be isolated by irradiation with X or ultra-violet rays. The virus neutralized with the specific antiserum did not cause any pathological symptoms in rats or rabbits. Serums of affected rats did not contain virus antibodies, while those of affected rabbits sometimes contained them. Hemorrhagic disease of rats and fibromatosis of rabbits are interesting models for the study of the interrelation between virus and cell.
Prospective evaluation of panic potentiation following 35% CO2 challenge in nonclinical subjects
Authors: P J Harrington, N B Schmidt, M J Telch
Journal: American Journal of Psychiatry (1996)

The authors examined the effect of panic provocation on the subsequent development of panic attacks and panic disorder in nonclinical subjects with no history of spontaneous panic.Sixty-two subjects who had completed a study examining fearful responses to a single vital capacity inhalation of 35% CO2 were reevaluated 1 year following the challenge test.Challenge-induced panic was not related to the later development of panic or panic disorder. According to the Structured Clinical Interview for DSM-III-R--Non-Patient Edition, none of the subjects met DSM-III-R criteria for panic disorder and only six subjects reported spontaneous panic during the year after panic provocation. Of the six subjects who experienced spontaneous panic, two had panicked in response to the CO2 challenge.The experimental provocation of panic in nonclinical subjects appears to be a safe research paradigm for exploring the psychopathogenicity of panic disorder.
The genome of the yellow potato cyst nematode, Globodera rostochiensis, reveals insights into the basis of parasitism and virulence
Authors: Sebastian Eves-van den Akker, Dominik R. Laetsch, Peter Thorpe, Catherine J. Lilley, Etienne G. J. Danchin, Martine Da Rocha, Corinne Rancurel, Nancy E. Holroyd, James A. Cotton, Amir Szitenberg, Eric Grenier, Josselin Montarry, Benjamin Mimee, Marc-Olivier Duceppe, Ian Boyes, Jessica M. C. Marvin, Laura M. Jones, Hazijah B. Yusup, Joël Lafond-Lapalme, Magali Esquibet, Michael Sabeh, Michael Rott, Hein Overmars, Anna Finkers-Tomczak, Geert Smant, Georgios Koutsovoulos, Vivian Blok, Sophie Mantelin, Peter J. A. Cock, Wendy Phillips, Bernard Henrissat, Peter E. Urwin, Mark Blaxter, John T. Jones
Journal: Genome biology (2016)

The yellow potato cyst nematode, Globodera rostochiensis, is a devastating plant pathogen of global economic importance. This biotrophic parasite secretes effectors from pharyngeal glands, some of which were acquired by horizontal gene transfer, to manipulate host processes and promote parasitism. G. rostochiensis is classified into pathotypes with different plant resistance-breaking phenotypes. We generate a high quality genome assembly for G. rostochiensis pathotype Ro1, identify putative effectors and horizontal gene transfer events, map gene expression through the life cycle focusing on key parasitic transitions and sequence the genomes of eight populations including four additional pathotypes to identify variation. Horizontal gene transfer contributes 3.5 % of the predicted genes, of which approximately 8.5 % are deployed as effectors. Over one-third of all effector genes are clustered in 21 putative 'effector islands' in the genome. We identify a dorsal gland promoter element motif (termed DOG Box) present upstream in representatives from 26 out of 28 dorsal gland effector families, and predict a putative effector superset associated with this motif. We validate gland cell expression in two novel genes by in situ hybridisation and catalogue dorsal gland promoter element-containing effectors from available cyst nematode genomes. Comparison of effector diversity between pathotypes highlights correlation with plant resistance-breaking. These G. rostochiensis genome resources will facilitate major advances in understanding nematode plant-parasitism. Dorsal gland promoter element-containing effectors are at the front line of the evolutionary arms race between plant and parasite and the ability to predict gland cell expression a priori promises rapid advances in understanding their roles and mechanisms of action.
Pacemaker Acceleration
Authors: John J. Rozanski
Journal: JAMA (1975)

<h3>To the Editor.—</h3> Since patients with cardiac pacemakers are so common in modern clinical medicine, we would like to call attention to the problem of subtle pacemaker acceleration. Most pacers have now been designed so that acceleration cannot occur.<sup>1</sup>"Runaway," not uncommonly seen with earlier-model pacers, is rarely reported today (228:340, 1974). However, slight acceleration, which may indicate component or battery failure, does occur. We report the following case as an example. An 83-year-old man was admitted to the hospital when his current pacemaker (Stanicor, model 143J7-27946) increased in rate from 70 to 80 beats per minute suddenly over 24 hours. The current pacer had been implanted 17 months before. An electrocardiogram demonstrated an R-R interval change from 860 to 760 msec (Figure). This was confirmed on repeated cardiograms with a different machine. The patient was immediately taken to surgery, and a new generator was implanted. Slight acceleration of