tbuckley/cabot-search huggingface dataset:
THE FUNCTION OF THE SWEAT GLANDS
Authors: M GILIC
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis and Therapy in Gastrointestinal Hemorrhage
Authors: R Liebeskind
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0198 The Relation Between Inflammation, Carotid Intima-Media Thickness and Low-Density Lipoprotein Cholesterol–High-Density Lipoprotein Cholesterol Ratio in Ankylosing Spondylitis Patients
Authors: A. Kucuk, A.U. Uslu, S. Arslan, K. Turkmen, A. Toker, M. Kayrak
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Ankylosing Spondylitis (AS) is a chronic inflammatory disease that mainly affects the spine and sacroiliac joints, and is often causing deformity and loss of function (1). AS, can also affect non-vertebral tissues and organs such as cardiac, ocular and gastrointestinal tract. Cardiovascular (CVS) mortality is increased in other rheumatic diseases (2). <h3>Objectives</h3> To evaluate the relation between carotid intima-media thickness and low-density lipoprotein (LDL) cholesterol - high-density lipoprotein (HDL) cholesterol ratio as indicators of atherosclerosis and ischemic modified albumin (IMA) and total antioxidant status (TOS) as markers of inflammation and oxidative stress in patients with AS. <h3>Methods</h3> Sixty AS patients and 54 healthy controls were included in our study. BASDAI and BASFI disease activity scores were recorded. The participants serum lipid panel, IMA and TOS levels were measured. Carotid intima-media thickness (CIMT) of patients and healthy subjects were measured. <h3>Results</h3> There were no differences between groups in terms of age, gender and Body mass index (BMI). LDL -HDL ratio was higher in AS patients compared to healthy subjects (2.85±1.00, 2.47±0.90, respectively, p&lt;0.047) AS patients had higher IMA values compared to healthy subjects as well (0.44±0.17, 0.32±0.13, respectively, p&lt;0.0001). AS patients had higher TOS values compared to healthy subjects as well (212.57±149.44, 116.70±122.98, respectively, p&lt;0.005). Also CIMT was significantly higher in AS patients compared to healthy subjects (0.99±0.27, 0.76±0.25, respectively, p&lt;0.0001). There was no correlation between CIMT, IMA and TOS. We also did not find correlation between IMA, TOS values and BASDAI and BASFI. However, there was a positive correlation between LDL-HDL ratio and CIMT (r=0.395, p=0.002) (figure 1). <h3>Conclusions</h3> LDL-HDL ratio and CIMT as markers of atherosclerosis are found to be higher in patients with AS. These findings might be the main reasons of increased CV morbidity and mortality in this population. <h3>References</h3> Daikh DI, Chen PP. Advances in managing ankylosing spondylitis. F1000prime reports. 2014;6:78. Mason JC, Libby P. Cardiovascular disease in patients with chronic inflammation: mechanisms underlying premature cardiovascular events in rheumatologic conditions. European heart journal. 2014 Nov 27. <h3>Disclosure of Interest</h3> None declared
Swainsonine Stimulation of the Proliferation and Colony Forming Activity of Murine Bone Marrow
Authors: S L White, T Nagai, S K Akiyama, E J Reeves, K Grzegorzewski, K Olden
Journal: Cancer Communications (1991)

Swainsonine, an indolizidine alkaloid, was recently reported to exhibit both antineoplastic and immunomodulatory activities (Humphries, M.J.; Olden, K. Asparagine-linked oligosaccharides and tumor metastasis. Pharmacol. Ther. 44:85-105; 1989). In this study, we show that systemically administered swainsonine promoted the proliferation of murine bone marrow (BM) cells. Animals that received swainsonine intravenously exhibited a significant increase (approximately 5-10 fold) in BM cellularity, engraftment efficiency, and colony forming unit activity using in vitro or in vivo assays. BM cells derived from swainsonine-treated animals or treated with swainsonine in vitro also exhibited a 4-5 fold increase in [3H]-thymidine incorporation, suggesting that a larger fraction of the cells was in the S-phase of the cell cycle. This provides the first evidence that swainsonine, which stimulates the production of cytokines by cells of the immune system, promoted the proliferation of BM progenitor cells. These results suggest that swainsonine could prove valuable in patients undergoing intensive chemoradiotherapy or autologous BM transplantation by decreasing or possibly eliminating leukopenia or myelosuppression often associated with these procedures; it may also be a useful probe to investigate the mechanism of normal hematopoieses.
Abstract 18153: Abnormal Dynamic Myocardial Response to Exercise Despite Normal Resting Ejection Fraction in Childhood Cancer Survivors Treated With Anthracyclines
Authors: Ching Kit - Chen, Barbara Cifra, Cameron Slorach, Cedric Manlhiot, Brian W McCrindle, Andreea Dragulescu, Mark K Friedberg, Andrew N Redington, Paul C Nathan, Luc Mertens
Journal: Circulation (2014)

Introduction: There are limited data on myocardial systolic &amp; diastolic response to exercise in pediatric cancer survivors treated with anthracycline. We used exercise echocardiography to evaluate ventricular systolic and diastolic reserve in these patients. Methods: 50 children (age 14.4±2.4 years) who had received anthracycline treatment with median dose 178mg/m 2 (range 60-450) underwent stepwise exercise echocardiography at 9.3±2.9 years after end of therapy, and compared with 50 normal controls. All subjects had normal resting LVEF. Peak systolic (s’) &amp; early diastolic (e’) myocardial velocities in the LV &amp; RV lateral wall, &amp; basal septum were measured at rest &amp; during exercise using color TDI. Measurements of myocardial isovolumic acceleration (IVA) at incremental heart rates (HR) were used to study force-frequency relationships (FFR). Results: At rest, LV systolic parameters were preserved in patients; septal e’ was significantly lower compared to controls (10.4±1.9cm/s vs 11.4±1.9cm/s; p =0.009). At peak exercise, LV &amp; RV lateral wall, &amp; basal septal e’ velocities were lower in patients (17.4±3.8cm/s vs 19.6±3.1cm/s, p =0.002; 21.5±1.6cm/s vs 22.3±1.9cm/s, p =0.02; &amp; 16.3±2.4cm/s vs 18.7±2.7cm/s, p &lt;0.001; respectively) &amp; the slopes of change with increasing HR were significantly lower in patients for LV lateral e’ [EST (SE): +0.68 (0.08) vs +0.85 (0.05) cm/s per 10 bpm; p &lt;0.001], RV lateral e’ [+1.47 (0.05) vs 1.69 (0.06) cm/s per 10 bpm; p &lt;0.001] &amp; basal septum e’ [+0.50 (0.05) vs 0.58 (0.05) cm/s per 10 bpm; p =0.001]. During exercise, peak contractile force developed by patients was significantly lower (LV IVA 5.12±1.85m/s 2 vs 6.75±3.28m/s 2 ; p =0.004). FFR analysis showed reduced rate-contractility trajectory in patients [+0.202 (0.008) vs +0.217 (0.008) natural log m/s 2 per 10 bpm; p =0.001]. Conclusions: Long-term survivors of anthracycline-treated pediatric cancer have reduced systolic &amp; diastolic myocardial reserve in response to exercise.
AB0882 BMD and TBS use in Adult Patients Suffering Polio
Authors: D. Grados, S. Di Gregorio, A. Pasarin, N. Allue, E. Bonel, M. García, R. Winzenrieth, L. del Rio, A. Erra
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> Assess TBS to categorize skeletal status in adult subject which history of Poliomyelitis sequels in limbs. <h3>Methods</h3> We scan total body, lumbar spine (L1-L4) and both hips (Total femur and Femoral Neck ROI9s) in 58 patients with history of poliomyelitis infection and limb paralysis (men: 14 -57.5 years; women: 48 -57±8.5 years). A DXA device GE-iDXA model was used. The difference between affected extremity and the opposite in BMD T-score and trabecular microarchitecture assessed by TBS (TBS® Insight; Medimaps) were used. The results were stratified as normal, low bone density or osteoporosis taking the lower T-score of the scanned regions of interest. TBS results were categorized as normal (TBS N) ≥1.350; partially deteriorated-(TBS-PD) between: 1.250 -1.349, and significantly deteriorated (TBS-SD): &lt;1.250. <h3>Results</h3> Three patients had hip fracture history. The left limb was the extremity most affected in this group (32 vs 20). Five patients had both extremities affected, with more severe affectation on the right side (4/5). Only 7 patients had normal BMD of the hip, which contrasts with the 43.1% of patients with normal lumbar BMD. The TBS was normal in 16 patients (27.6%). Stratification was more similar in patients who had a low bone density (48.3% in the hip and 50% in lumbar spine) and TBS-PD (50%). In patients categorized as osteoporotic the lowest T-score of BMD was found in proximal femur (39.7%) of the most affected limb, the T-score BMD of the lumbar spine in 6.9% of the patients, while the TBS-SD was found at 22.4%. The DXA spine images showed a spondyloarthritis and scoliosis signs in 25 patients. 16.7% of patients had a osteoporotic T-score in affected femur and had normal BMD at the lumbar spine and opposite femur, but interestingly had a deteriorated TBS (TBS-PPD and TB SSD). <h3>Conclusions</h3> A degradation TBS allow identify a greater number of patients who had polio with low bone status than assess BMD of lumbar spine and femur. Postural instability could increase irregular mechanical charges to lumbar spine and femur unaffected that may decrease the sensitivity of DXA when only the BMD is used to classify patients. <h3>Disclosure of Interest</h3> None declared
FRI0512 The Successful Use of Rituximab in Three Patients with Juvenile Systemic Sclerosis
Authors: D. Alekseev, I. Nikishina, L. Ananjeva, N. Kuzmina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To assess the value of rituximab (RTM) in a limited series of patients (pt) with juvenile systemic sclerosis (jSSc). <h3>Methods</h3> Three patients with jSSc were evaluated: 2 girls (ptA and ptB), 1 boy (ptC) with onset at 7, 8 and 7 years, and duration of the disease at the beginning of therapy 4, 6 and 7 years, all with diffuse form of jSSc. Patients had a high activity and aggressive course of the disease with predominant pulmonary (interstitial lung disease – ptA, ptB), heart (ptC), microcirculatory disturbances (ptA, ptB), typical and severe skin lesions and musculoskeletal system, immunological activity (ANA "+" - all, aScl70 "+" - ptA and ptB, ACA "+" – ptC). Therapy, previous RTM, included corticosteroids, cyclophosphamide, blockers ACE alprostadil. They received RTM at a dose of 375 mg/m<sup>2</sup> every 6 months; ptA received 4 infusions, pnB – 3, ptC – 6, with a total duration of use of RTM 24, 18 and 36 months. The use of RTM approved by local ethics committee. <h3>Results</h3> Improvement was noted in all patients. The first manifestations of improvement established after 6 months of the RTM treatment with subsequent increase. All patients showed marked improvement in health, increased exercise tolerance, reduction of skin tightening (after 6 months of therapy there was a decrease of the Rodnan total skin thickness score, 6 points; with a further decrease in accordance with the duration of the treatment), sclerodactyly, improving joint function (polyarthropathies), a gradual increase in DLCO, FVC (6-8%), indicators of heart disease (ptC, with a dominant extremely serious cardiac disease, reducing the size of the left ventricular end-diastolic dimension, from 58 to 52 mm, increase in ejection fraction from 32 to 48%, reducing the number of ventricular ectopic beats per day from 19,657 to 1,671). During the period of treatment revealed no significant adverse events associated with the use of rituximab. <h3>Conclusions</h3> The results of our observations of small number of patients with severe jSSc who had RTM therapy suggests that the use of RTM is a promising treatment for jSS with the presence of a good therapeutic effect, with an acceptable adverse event profile, reduces the need for glucocorticoids, limit the use of cytotoxic drugs. Further studies of the efficacy of this therapy in the treatment of jSSc are needed. <h3>Disclosure of Interest</h3> None declared
Assessment of global guidelines for preventive chemotherapy against schistosomiasis and soil-transmitted helminthiasis: a cost-effectiveness modelling study
Authors: Nathan C Lo, Ying-Si Lai, Dimitrios-Alexios Karagiannis-Voules, Isaac I Bogoch, Jean T Coulibaly, Eran Bendavid, Jürg Utzinger, Penelope Vounatsou, Jason R Andrews
Journal: The Lancet Infectious Diseases (2016)
Improved Diagnostic Accuracy of SPECT Through Statistical Analysis and the Detection of Hot Spots at the Primary Sensorimotor Area for the Diagnosis of Alzheimer Disease in a Community-Based Study
Authors: Tomohiro Kaneta, Masahiro Nakatsuka, Kei Nakamura, Takashi Seki, Satoshi Yamaguchi, Masahiro Tsuboi, Kenichi Meguro
Journal: Clinical Nuclear Medicine (2015)

Purpose SPECT is an important diagnostic tool for dementia. Recently, statistical analysis of SPECT has been commonly used for dementia research. In this study, we evaluated the accuracy of visual SPECT evaluation and/or statistical analysis for the diagnosis (Dx) of Alzheimer disease (AD) and other forms of dementia in our community-based study “The Osaki-Tajiri Project.” Patients and Methods Eighty-nine consecutive outpatients with dementia were enrolled and underwent brain perfusion SPECT with 99mTc-ECD. Diagnostic accuracy of SPECT was tested using 3 methods: visual inspection (SPECT Dx), automated diagnostic tool using statistical analysis with easy Z-score imaging system (eZIS Dx), and visual inspection plus eZIS (integrated Dx). Results Integrated Dx showed the highest sensitivity, specificity, and accuracy, whereas eZIS was the second most accurate method. We also observed that a higher than expected rate of SPECT images indicated false-negative cases of AD. Among these, 50% showed hypofrontality and were diagnosed as frontotemporal lobar degeneration. These cases typically showed regional “hot spots” in the primary sensorimotor cortex (ie, a sensorimotor hot spot sign), which we determined were associated with AD rather than frontotemporal lobar degeneration. Conclusion We concluded that the diagnostic abilities were improved by the integrated use of visual assessment and statistical analysis. In addition, the detection of a sensorimotor hot spot sign was useful to detect AD when hypofrontality is present and improved the ability to properly diagnose AD.
Learning endoscopic resection in the esophagus
Authors: Frederike van Vilsteren, Roos Pouw, Lorenza Alvarez Herrero, Raf Bisschops, Martin Houben, Frans Peters, B. Schenk, Bas Weusten, Erik Schoon, Jacques Bergman
Journal: Endoscopy (2015)

<b>Background:</b> Endoscopic resection is the cornerstone of endoscopic management of esophageal early neoplasia. However, endoscopic resection is a complex technique requiring knowledge and expertise. Our aims were to identify the most important learning points in performing endoscopic resection in a training setting and to provide information on how to improve endoscopic resection technique. <b>Methods: </b>Six gastroenterologists at centers with multidisciplinary expertise in upper gastrointestinal oncology participated in a structured endoscopic resection training program, consisting of four training days with lectures and hands-on training on live pigs, further one-to-one hands-on training days, and written feedback (by an expert) on videos of unsupervised endoscopic resection procedures. The first 20 endoscopic resections of each participant were prospectively registered. Ninety learning points were independently identified by participants using a standardized questionnaire and by an expert providing written feedback on 33 unsupervised endoscopic resection videos. Three expert endoscopists selected and ranked the most important learning points in a consensus meeting. <b>Results.</b> The top 10 tips (illustrated by unique videos of three perforations) were: (1) allow time for inspection and use a high-definition endoscope; (2) create a preprocedural plan by placing electrocoagulation markings; (3) know the management of bleeding; (4) optimize the endoscopic view by repeatedly cleaning out stomach and target area; (5) use a therapeutic endoscope during resection; (6) always perform a test suction; (7) keep instruments close to the tip; (8) lift edges in piecemeal endoscopic cap resections; (9) know the management of perforation; (10) pin specimens down. <b>Conclusions:</b> This study summarized the most important learning points for performing endoscopic resection encountered during a structured endoscopic resection training program.
Oxygen Consumption of Soleus Muscles from Normal, Vitamin E-Supplemented and Vitamin E-Deficient Guinea Pigs During Rest and Stimulation
Authors: J W BIRD, D D SCHOTTELIUS, B A SCHOTTELIUS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severity of cocaine dependence as a predictor of relapse to cocaine use
Authors: R D Weiss, M L Griffin, C Hufford
Journal: American Journal of Psychiatry (1992)

The severity of cocaine dependence of 39 hospitalized patients was assessed by administering the Structured Clinical Interview for DSM-III-R. No significant relationship was found between severity of cocaine dependence and cocaine use at 3-month follow-up. These findings suggest that severity of cocaine dependence may be a poor predictor of relapse to cocaine use.
Cardiovascular Actions of Nicotine and Smoking<xref ref-type="fn" rid="FN1">1</xref>
Authors: H Schievelbein, R Eberhardt
Journal: JNCI Journal of the National Cancer Institute (1972)

Cardiovascular Actions of Nicotine and Smoking Get access H. Schievelbein, M.D., H. Schievelbein, M.D. Abteilung für Präventivmedizin, Institut für Klinische Chemie und Klinische Biochemie der Universität, München, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar Reinhild Eberhardt, M.D. Reinhild Eberhardt, M.D. Abteilung für Präventivmedizin, Institut für Klinische Chemie und Klinische Biochemie der Universität, München, Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 6, June 1972, Pages 1785–1794, https://doi.org/10.1093/jnci/48.6.1785 Published: 01 June 1972
Molecular and Functional Imaging of Bone Metastases in Breast and Prostate Cancers
Authors: Gurdip Kaur Azad, Benjamin Taylor, Domenico Rubello, Patrick M. Colletti, Vicky Goh, Gary J. Cook
Journal: Clinical Nuclear Medicine (2015)

Our ability to accurately assess the skeleton for metastases in breast and prostate cancers has improved significantly in recent years with hybrid imaging methods. Nevertheless, no consensus has been reached on the best imaging modality for diagnosis and treatment response assessment of skeletal disease. Hybrid SPECT/CT has low false-positive and false-negative rates compared with planar bone scintigraphy (BS) or BS augmented with SPECT in breast and prostate cancers. In breast cancer, 18F-FDG PET is more sensitive and accurate at detecting bone metastases than BS. Currently, little evidence has accrued to support the superiority of 18F-fluoride (18F-NaF) PET in diagnosing osseous metastases or monitoring treatment response in breast cancer when compared with conventional imaging. In prostate cancer, the sensitivities of 18F-NaF PET/CT, 18F-fluorocholine (18F-choline), or 11C-choline PET/CT are equivalent, although 11C-/18F-choline PET/CT scans are more specific. Whole-body MRI, using anatomical sequences complemented by diffusion-weighted MRI, shows early evidence of utility for diagnosis and monitoring therapy response. We review the literature for staging and response assessment in metastatic breast and prostate cancer. While staging accuracy has significantly improved with hybrid imaging, optimal methods for assessing early treatment response have not been determined, and this is an area of active research.
Are lawyers enemies of psychiatrists? A survey of civil commitment counsel and judges
Authors: V A Hiday
Journal: American Journal of Psychiatry (1983)

The author surveyed 101 attorneys and judges involved in civil commitment procedures to answer the question of how they view psychiatrists, mental hospitals, and the mentally ill. She found that these lawyers and judges tended to view psychiatrists in favorable terms, that their attitudes toward mental hospitals reflected their perception of the weaknesses of these hospitals and their view of hospitalization as a last resort, and that they tended to reject negative statements about the mentally ill. She discusses the effect of these attitudes on the behavior of lawyers and judges toward psychiatrists and the mentally ill in civil commitment hearings.