tbuckley/cabot-search huggingface dataset:
Results of neoadjuvant chemoradiotherapy with docetaxel and 5-fluorouracil followed by esophagectomy to treat locally advanced esophageal cancer.
Authors: Yoichi Hamai, Jun Hihara, Takaoki Furukawa, Ichiko Yamakita, Morihito Okada
Journal: Journal of Clinical Oncology (2015)

e15084 Background: Esophageal cancer is most frequently treated with platinum-based chemoradiotherapy (CRT). We previously described a Phase I study of definitive CRT with docetaxel (DOC) and 5-fluorouracil (5FU) in patients with advanced esophageal cancer. This regimen had low toxicity and was effective without platinating agents. The present study aims to determine the antitumor effects of neoadjuvant CRT with DOC and 5FU and surgical outcomes. Methods: We reviewed data from 38 patients with locally advanced cancer of the esophagus or esophagogastric junction who underwent trimodality therapy comprising neoadjuvant CRT with DOC and 5FU followed by esophagectomy between 2003 and 2008. Results: Esophagitis was the most common toxicity associated with neoadjuvant CRT (Grade 3; 26.3%), and hematological toxicity was mild. Transthoracic esophagectomy and pharyngolaryngoesophagectomy proceeded in 36 (94.7%) and 2 (5.3%) patients, respectively, and 35 (92.1%) underwent R0 resection. Five (13.2%) patients had complete pathological responses (pCR) of the primary tumor, and 23 (60.5%) had pathological reductions of over two-thirds of the primary tumor. T or N status was also down-staged in 26 (68.4%) patients. Overall postoperative morbidity developed in 21 (55.3%) patients, and mortality due to postoperative morbidity was zero. The five-year recurrence-free and overall survival rates were 39.5% and 44.7%, respectively. Conclusions: The rate of neoadjuvant CRT toxicity and postoperative complications were acceptable, and the complete resection rate and survival data were favorable. This regimen is promising as neoadjuvant CRT for esophageal cancer and very useful as an alternative regimen for treating patients with esophageal cancer who cannot tolerate cisplatin.
Heterogeneity of amphetamine response in depressed patients
Authors: E K Silberman, V I Reus, D C Jimerson, A M Lynott, R M Post
Journal: American Journal of Psychiatry (1981)

There is considerable diversity of opinion as to the nature of the response of depressed patients to amphetamine infusion. The authors report on the clinical response of 18 endogenously depressed patients to double-blind, intravenous administration of amphetamine or saline. Although the drug produced activation, mood elevation, and recall of emotionally charged material in the group as a whole, there was considerable heterogeneity of response as well as a tendency for response dimensions to vary independently of one another. The heterogeneity of clinical response may be associated with differences in underlying clinical, biological, and genetic variables in affectively ill patients.
Optimizing Surveillance and Balancing Evidence With Patient Expectations
Authors: Crystal Denlinger, Terry S. Langbaum
Journal: Journal of the National Comprehensive Cancer Network (2014)

For most cancers, intensive posttreatment surveillance does not improve survival, but can induce anxiety in patients and may lead to unnecessary testing due to false-positive results. For colorectal cancer, more intensive surveillance, especially during the first few survivorship years, is warranted. For breast cancer, surveillance for second primary cancers with annual mammography is warranted. This may also be the case for non-small cell lung cancer. For other tumors, less routine surveillance testing can be recommended.
The difference between trivial and scientific names: There were never any true cheetahs in North America
Authors: S. Faurby, L. Werdelin, J. C. Svenning
Journal: Genome biology (2016)

Dobrynin et al. (Genome Biol 16:277, 2015) recently published the complete genome of the cheetah (Acinonyx jubatus) and provided an exhaustive set of analyses supporting the famously low genetic variation in the species, known for several decades. Their genetic analyses represent state-of-the-art and we do not criticize them. However, their interpretation of the results is inconsistent with current knowledge of cheetah evolution. Dobrynin et al. suggest that the causes of the two inferred bottlenecks at ∼ 100,000 and 10,000 years ago were immigration by cheetahs from North America and end-Pleistocene megafauna extinction, respectively, but the first explanation is impossible and the second implausible.
Exercise training prevents ventricular tachycardia in CPVT1 due to reduced CaMKII-dependent arrhythmogenic Ca<sup>2+</sup>release
Authors: Ravinea Manotheepan, Tore K. Danielsen, Mani Sadredini, Mark E. Anderson, Cathrine R. Carlson, Stephan E. Lehnart, Ivar Sjaastad, Mathis K. Stokke
Journal: Cardiovascular Research (2016)

Catecholaminergic polymorphic ventricular tachycardia type 1 (CPVT1) is caused by mutations in the cardiac ryanodine receptor (RyR2) that lead to disrupted Ca(2+) handling in cardiomyocytes and ventricular tachycardia. The aim of this study was to test whether exercise training could reduce the propensity for arrhythmias in mice with the CPVT1-causative missense mutation Ryr2-R2474S by restoring normal Ca(2+) handling.Ryr2-R2474S mice (RyR-RS) performed a 2 week interval treadmill exercise training protocol. Each exercise session comprised five 8 min intervals at 80-90% of the running speed at maximal oxygen uptake (VO2max) and 2 min active rest periods at 60%. VO2max increased by 10 ± 2% in exercise trained RyR-RS (ET), while no changes were found in sedentary controls (SED). RyR-RS ET showed fewer episodes of ventricular tachycardia compared with RyR-RS SED, coinciding with fewer Ca(2+) sparks and waves, less diastolic Ca(2+) leak from the sarcoplasmic reticulum, and lower phosphorylation levels at RyR2 sites associated with Ca(2) (+)-calmodulin-dependent kinase type II (CaMKII) compared with RyR-RS SED. The CaMKII inhibitor autocamtide-2-related inhibitory peptide and also the antioxidant N-acetyl-l-cysteine reduced Ca(2+) wave frequency in RyR-RS equally to exercise training. Protein analysis as well as functional data indicated a mechanism depending on reduced levels of oxidized CaMKII after exercise training. Two weeks of detraining reversed the beneficial effects of the interval treadmill exercise training protocol in RyR-RS ET.Long-term effects of interval treadmill exercise training reduce ventricular tachycardia episodes in mice with a CPVT1-causative Ryr2 mutation through lower CaMKII-dependent phosphorylation of RyR2.
A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus
Authors: Ming Li, Andrew E Jaffe, Richard E Straub, Ran Tao, Joo Heon Shin, Yanhong Wang, Qiang Chen, Chao Li, Yankai Jia, Kazutaka Ohi, Brady J Maher, Nicholas J Brandon, Alan Cross, Joshua G Chenoweth, Daniel J Hoeppner, Huijun Wei, Thomas M Hyde, Ronald McKay, Joel E Kleinman, Daniel R Weinberger
Journal: Nature Medicine (2016)
Clinical Significance Of SF3B1, U2AF1 and SRSF2 Spliceosomal Gene Mutations For The Treatment Of Hypomethylating Agents In Myelodysplastic Syndrome
Authors: Jae-Sook Ahn, Hye-Ran Kim, Hyeoung-Joon Kim, Yeo-Kyeoung Kim, Sung-Hoon Jung, Deok-Hwan Yang, Je-Jung Lee, Nguyen Thi Dai Trang, Hyun-Woo Choi, Min-Gu Kang, Hwan-Young Kim, Jong-Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Myung-Geun Shin
Journal: Blood (2013)
Seroprevalence of brucellosis in animals and human populations in the western mountains region in Libya, December 2006–January 2008
Authors: M O Ahmed, S E Elmeshri, A R Abuzweda, M Blauo, Y M Abouzeed, A Ibrahim, H Salem, F Alzwam, S Abid, A Elfahem, A Elrais
Journal: Eurosurveillance (2010)

Brucellosis is a global zoonotic disease, endemic in North African countries and around the Mediterranean.A prospective study of Brucella seroprevalence was conducted in north-western Libya (western mountains region). Blood samples collected over 13 months in the period December 2006 to January 2008 from 561 animals (goats, sheep, cattle and camels) and 546 human volunteers were tested for Brucella using the Rose Bengal test, tube agglutination test and ELISA assays. Amongst livestock, 31% of goats and 42% of cattle were seropositive. Human samples showed a high seropositivity of 40%, with 95 (43%) of the 221 positive samples positive for IgM, indicating active or recent infection. Control measures are needed to reduce this high prevalence of brucellosis in Libya.
Corporate Funding of Nutrition Research and Unjustified Conclusions
Authors: Richard Kahn
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Phosphoproteomic Profiling of the Signaling Output of FLT3-ITD and Its AC220-Resistant Mutants Reveals Profound Signaling Differences and Differential Responsiveness to Inhibition of Downstream Kinases
Authors: Carmen Doebele, Johannes Kovar, Diego Yepes, Silvia Münch, Frank Schnütgen, Hanibal Bohnenberger, Anne Köhler, Henning Urlaub, Hubert Serve, Thomas Oellerich
Journal: Blood (2015)
Tobacco companies lose legal challenge on standardised packaging
Authors: Clare Dyer
Journal: BMJ (2016)

Tobacco multinationals have failed to block a European directive mandating standardised packaging for tobacco products across Europe.

The European Court of Justice ruled on 4 May that the European tobacco directive 2014, which states that health warnings must cover 65% of the front and back of a cigarette pack sold in the single market, is lawful.1

The court also held that the directive allows European Union member states to go further and introduce extra measures on packaging that are not harmonised by the directive. This would include a UK law, due to come into force in May 2017, allowing cigarettes …
Double Knockout of the Na+-Driven Cl−/HCO3 − Exchanger and Na+/Cl− Cotransporter Induces Hypokalemia and Volume Depletion
Authors: Anne Sinning, Nikita Radionov, Francesco Trepiccione, Karen I. López-Cayuqueo, Maximilien Jayat, Stéphanie Baron, Nicolas Cornière, R. Todd Alexander, Juliette Hadchouel, Dominique Eladari, Christian A. Hübner, Régine Chambrey
Journal: Journal of the American Society of Nephrology (2016)

We recently described a novel thiazide-sensitive electroneutral NaCl transport mechanism resulting from the parallel operation of the Cl-/HCO3- exchanger pendrin and the Na+-driven Cl-/2HCO3- exchanger (NDCBE) in β-intercalated cells of the collecting duct. Although a role for pendrin in maintaining Na+ balance, intravascular volume, and BP is well supported, there is no in vivo evidence for the role of NDCBE in maintaining Na+ balance. Here, we show that deletion of NDCBE in mice caused only subtle perturbations of Na+ homeostasis and provide evidence that the Na+/Cl- cotransporter (NCC) compensated for the inactivation of NDCBE. To unmask the role of NDCBE, we generated Ndcbe/Ncc double-knockout (dKO) mice. On a normal salt diet, dKO and single-knockout mice exhibited similar activation of the renin-angiotensin-aldosterone system, whereas only dKO mice displayed a lower blood K+ concentration. Furthermore, dKO mice displayed upregulation of the epithelial sodium channel (ENaC) and the Ca2+-activated K+ channel BKCa. During NaCl depletion, only dKO mice developed marked intravascular volume contraction, despite dramatically increased renin activity. Notably, the increase in aldosterone levels expected on NaCl depletion was attenuated in dKO mice, and single-knockout and dKO mice had similar blood K+ concentrations under this condition. In conclusion, NDCBE is necessary for maintaining sodium balance and intravascular volume during salt depletion or NCC inactivation in mice. Furthermore, NDCBE has an important role in the prevention of hypokalemia. Because NCC and NDCBE are both thiazide targets, the combined inhibition of NCC and the NDCBE/pendrin system may explain thiazide-induced hypokalemia in some patients.
Removal of Sebaceous Cysts: Modification in Technique
Authors: B KANEE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib
Authors: Guang Yang, Sara J. Buhrlage, Li Tan, Xia Liu, Jie Chen, Lian Xu, Nicholas Tsakmaklis, Jiaji G. Chen, Christopher J. Patterson, Jennifer R. Brown, Jorge J. Castillo, Wei Zhang, Xiaofeng Zhang, Shuai Liu, Philip Cohen, Zachary R. Hunter, Nathanael Gray, Steven P. Treon
Journal: Blood (2016)
Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation
Authors: Angelo S. Mao, Jae-Won Shin, David J. Mooney
Journal: Biomaterials (2016)

The mechanical properties of the microenvironment and direct contact-mediated cell-cell interactions are two variables known to be important in the determination of stem cell differentiation fate, but little is known about the interplay of these cues. Here, we use a micropatterning approach on polyacrylamide gels of tunable stiffnesses to study how homotypic cell-cell contacts and mechanical stiffness affect different stages of osteogenesis of mesenchymal stem cells (MSCs). Nuclear localization of transcription factors associated with osteogenesis depended on substrate stiffness and was independent of the degree of cell-cell contact. However, expression of alkaline phosphatase, an early protein marker for osteogenesis, increased only in cells with both direct contact with neighboring cells and adhesion to stiffer substrates. Finally, mature osteogenesis, as assessed by calcium deposition, was low in micropatterned cells, even on stiff substrates and in multicellular clusters. These results indicate that substrate stiffness and the presence of neighboring cells regulate osteogenesis in MSCs.
Glutamate Receptor Polymorphisms Contribute to Glucocorticoid-Associated Osteonecrosis
Authors: Tamara Chang, Wenjian Yang, Van Driest L Sara, Sue C. Kaste, Erica A Bowten, Melissa Basford, Lisa Bastarache, Dan M Roden, Joshua C Denny, Leonard A. Mattano, Eric C. Larsen, Naomi J. Winick, William L. Carroll, Cheng Cheng, Deqing Pei, Christian A. Fernandez, Chengcheng Liu, Colton Smith, Mignon Loh, Elizabeth A Raetz, Stephen Hunger, Paul Scheet, Sima Jeha, Ching-Hon Pui, William E. Evans, Meenakshi Devidas, Mary V. Relling
Journal: Blood (2014)
What is the association between sedentary behaviour and cognitive function? A systematic review
Authors: Ryan S Falck, Jennifer C Davis, Teresa Liu-Ambrose
Journal: British Journal of Sports Medicine (2016)

The increasing rate of all-cause dementia worldwide and the lack of effective pharmaceutical treatments emphasise the value of lifestyle approaches as prevention strategies. Emerging evidence suggests sedentary behaviour is associated with impaired cognitive function. A better understanding of this association would significantly add to our knowledge of how to best promote healthy cognitive ageing. Thus, we conducted a systematic review ascertaining the contribution of sedentary behaviour towards associated changes in cognitive function over the adult lifespan.Systematic review of peer-reviewed literature examining the association of sedentary behaviour with cognition.We searched PubMed, PsycINFO, EBSCO and Web of Science, and reference lists of relevant reviews on sedentary behaviour. Two independent reviewers extracted (1) study characteristics and (2) information regarding measurement of sedentary behaviour and cognitive function. We also assessed study quality using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist.We limited search results to adults ≥40 years, observational studies published in English since 1990 and studies investigating associations between sedentary behaviour and cognitive function.8 studies examined the association of sedentary behaviour with cognitive function. 6 studies reported significant negative associations between sedentary behaviour and cognitive function. 8 different measures of sedentary behaviour and 13 different measures of cognitive function were used across all eight studies.Sedentary behaviour is associated with lower cognitive performance, although the attributable risk of sedentary time to all-cause dementia incidence is unclear. Our systematic review provides evidence that limiting sedentary time and concomitantly engaging in regular moderate-to-vigorous physical activity may best promote healthy cognitive ageing.
Opsoclonus-Myoclonus Syndrome in the Era of Neuronal Cell Surface Antibodies—Reply
Authors: Francesc Graus, Helena Ariño, Josep Dalmau
Journal: JAMA Neurology (2016)

In Reply We thank Gallerini and colleagues for bringing to our attention a new case of opsoclonus associated with a gastric adenocarcinoma. The patient confirms the tight association of older age with a paraneoplastic etiology of the opsoclonus.1
MPTH-07GLIOBLASTOMAS: CORRELATION OF MGMT GENE PROMOTER METHYLATION WITH CLINICO-PATHOLOGICAL AND MOLECULAR PARAMETERS
Authors: Sridhar Epari, Iteeka Arora, Mamta Gurav, Rachna Rumde, Sandeep Dhanavade, Vinayak Kadam, Hetakshi Kurani, Omshree Shetty, Tejpal Gupta, Jayant Sastri Goda, Prakash Shetty, Aliasgar Moiyadi, Rakesh Jalali
Journal: Neuro-Oncology (2015)

Methylation of O6-methylguanine DNA methyltransferase (MGMT) is one of the predictive and prognostic markers of glioblastomas (GBMs). In this study, GBMs have been evaluated for the same and correlated with other clinicopathological and molecular parameters. MATERIALS AND METHODS: Diagnosed cases of GBM, during the period of June 2014 to December 2014 in the Department of Pathology of our Institute, wherein they have been evaluated for MGMT methylation by methylation specific polymerase chain reaction, IDH1R132H and p53 protein expression by immunohistochemistry and EGFR gene amplification by fluorescence in-situ hybridisation formed the study sample. Statistical correlation was done by Chi-square and Fischer's exact, using IBM SPSS Software 16 version. RESULTS: A total of 97 cases of GBM formed the study sample with age range of 20-75 years (mean age:49.76 years) and male: female ratio of 3.2:1 (M:74;F:23).Cerebral hemispheric location was commonest (frontal:35%; temporal:43 & parietal:19%). 46 (47.4%) cases were MGMT methylated (low methylation: 10) and 51 were unmethylated. 23 out of 84 cases (27.4%) were EGFR amplified; 10 cases (10.3%) were positive for IDH1R132H; 16 showed loss of ATRX protein expression (of which 7 were IDH1R132H positive; while the other 3 IDHR132H positive cases showed retained ATRX protein). Of the 46 MGMT methylated cases, 10 were EGFR amplified (10 out of 23 EGFR amplified cases were MGMT methylated); 5 were IDH1R132H positive and 6 showed loss of ATRX expression. None of the molecular markers showed any correlation for the histological features of calcification and necrosis (neither for pseudopalisading or confluent). CONCLUSIONS: MGMT was methylated in 47.4%of GBMs and had no significant statistical correlation with EGFR gene amplification, IDH1R132H mutation, ATRX protein expression and other histomorphological features. This study did not identify any surrogate marker for MGMT promoter methylation.
Synthetic niche to modulate regenerative potential of MSCs and enhance skeletal muscle regeneration
Authors: Matthias Pumberger, Taimoor H. Qazi, M. Christine Ehrentraut, Martin Textor, Janina Kueper, Gisela Stoltenburg-Didinger, Tobias Winkler, Philipp von Roth, Simon Reinke, Cristina Borselli, Carsten Perka, David J. Mooney, Georg N. Duda, Sven Geißler
Journal: Biomaterials (2016)