Acid-Base Disorders and the Clinician
Authors: J. R. E.
Journal: Annals of Internal Medicine (1965)

Editorials1 November 1965Acid-Base Disorders and the ClinicianJ. R. E.J. R. E.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-893 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo most physicians acid-base regulation and its disorders are an abstruse subject that is of interest primarily to the mathematically or chemically minded specialist. Yet every doctor who cares for many sick patients, especially hospitalized patients, is confronted inevitably with those in whom such disturbances are an important part of their illness. In these patients accurate diagnosis and good treatment require on the part of the physician an adequate working knowledge of acid-base regulation and how it goes wrong in various disease states. The need for such knowledge becomes progressively more urgent as new insights are gained into the mechanisms...References1. CONFERENCE: Current Concepts of Acid-base Measurement. Ann. N. Y. Acad. Sci. 133: (in press), 1965. Google Scholar2. ELKINTON JR: Hydrogen ion turnover in health and in renal disease. Ann. Intern. Med. 57: 660, 1962. LinkGoogle Scholar3. SINGERHASTINGS RBAB: An improved method for the estimation of disturbances in the acid-base balance of human blood. Medicine 27: 223, 1948. CrossrefMedlineGoogle Scholar4. ASTRUPJORGENESNSIGGAARD-ANDERSENENGEL PKOK: Acid-base metabolism: new approach. Lancet 1: 1035, 1960. CrossrefMedlineGoogle Scholar5. SIGGAARD-ANDERSEN O: The Acid-base Status of the Blood. The Williams and Wilkins Co., Baltimore, 1964, 134 pages. Google Scholar6. SCHWARTZRELMAN WBAS: A critique of the parameters used in the evaluation of acid-base disorder. New Eng. J. Med. 268: 1382, 1963. CrossrefMedlineGoogle Scholar7. SIGGAARD-ANDERSEN O: Acute experimental acid-base disturbances in dogs. An investigation of the acid-base and electrolyte content of blood and urine. Scand. J. Clin. Lab. Invest. 1962, Suppl. 66. MedlineGoogle Scholar8. EDITORIAL: More acid/base disturbances. Lancet II, 1102, 1963. Google Scholar9. CORRESPONDENCE: Acid-base disorders. N. Eng. J. Med. 269: 588 and 817, 1963. CrossrefGoogle Scholar10. EDITORIAL: "Archives of acid-base balance." N. Eng. J. Med. 272: 48 and 317, 1965. CrossrefGoogle Scholar11. CORRESPONDENCE: "Archives of acid-base balance." N. Eng. J. Med. 272: 318, 1965. CrossrefMedlineGoogle Scholar12. BUNKER JP: Editorial: The great trans-Atlantic acid-base debate. J. Anesth. 26: 591, 1965. Google Scholar13. Uncertainty over the appropriate method of measurement of the metabolic component should not be carried over to the excellent instrument which was devised by one of the protagonists, Dr. Astrup. By the rapid determination of the pH of the blood sample as collected and at two known pressures of CO2, the actual PCO2 and bicarbonate, as well as standard bicarbonate and base excess, may be quickly estimated in microsamples. Google Scholar14. BRACKETTCOHENSCHWARTZ NCJJWB: Carbon dioxide titration curve of normal man. New Eng. J. Med. 272: 6, 1965. CrossrefMedlineGoogle Scholar15. SCHWARTZBRACKETTCOHEN WBNCJJ: The response of extracellular hydrogen ion concentration to graded degrees of chronic hypercapnia: the physiologic limits of the defense of pH. J. Clin. Invest. 44: 291, 1965. CrossrefMedlineGoogle Scholar16. SCHWARTZHAYSPOLAKHAYNIE WBRMAGD: Effects of chronic hypercapnia on electrolyte and acid-base equilibrium. II. Recovery, with special reference to the influence of chloride intake. J. Clin. Invest. 40: 1238, 1961. CrossrefMedlineGoogle Scholar17. ROBIN ED: Abnormalities of acid-base regulation in chronic pulmonary disease, with special reference to hypercapnia and extracellular alkalosis. New Eng. J. Med. 268: 917, 1963. CrossrefMedlineGoogle Scholar18. CANNONHEINEMANNALBERTLARAGHWINTERS PJHOMDJHRW: "Contraction" alkalosis after diuresis of edematous patients with ethacrynic acid. Ann. Intern. Med. 62: 979, 1965. LinkGoogle Scholar19. RELMAN AS: Editorial. What are "acids" and "bases"? Amer. J. Med. 17: 435, 1954. CrossrefMedlineGoogle Scholar20. CAMPBELL EJ: RIpH. Lancet 1: 681, 1962. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byClinical Approach to Assessing Acid-Base Status: Physiological vs StewartAssessing Acid-Base Status: Physiologic Versus Physicochemical ApproachAssessing acid–base disordersJ. Russell Elkinton, M.D., M.A.C.P.: A TributeMARSHALL N. FULTON, M.D.Acid-Base Response to Chronic Hypercapnia in ManClinical Disorders of Acid-Base Regulation: A Survey of Seventeen Years' Diagnostic ExperienceDefense of Hydrogen Ion Concentration in Chronic Metabolic Acidosis A New Evaluation of an Old ApproachEDWARD J. LENNON, M.D., JACOB LEMANN JR., M.D. 1 November 1965Volume 63, Issue 5Page: 893-899 ePublished: 1 December 2008 Issue Published: 1 November 1965 PDF downloadLoading ...