tbuckley/cabot-search huggingface dataset:
Cancer recurrence and survival in patients with early-stage triple-negative breast cancer in a U.S. local oncology practice.
Authors: L. Zhao, B. S. Seal, B. A. Feinberg, J. W. Gilmore, S. Haislip, S. D. Sullivan, N. P. Christiansen
Journal: Journal of Clinical Oncology (2010)

6114 Background: Breast cancer (BC) patients with triple negative (TN) status, defined as negative expression for estrogen, progesterone, and HER2 receptors, carry a poor prognosis. The objective of this study was to evaluate, in a real world context, the impact of TN status on disease recurrence and survival among early-stage BC patients treated with adjuvant chemotherapy (CT). Methods: The Georgia Cancer Specialist Database (2003-2004) was used. Patients with early stage (I-III) BC, confirmed TN/non-TN status, and treated with adjuvant CT were followed from initial BC diagnosis to the earliest of death, BC recurrence, or loss to follow-up. The primary outcome was disease free survival (DFS, defined as the time in which a patient is alive without recurrence). The secondary outcome was recurrence. Patients were stratified into TN and non-TN groups. Kaplan-Meier curves were used to compare the event rates between two groups. The impact of TN status on DFS and recurrence was further examined with multivariate Cox models, adjusting for age, comorbidity, body mass index, smoking status, BC stage, surgical, and radiological therapies. Results: The study sample included 1,572 patients, with 26.3% (n = 414) being TN. The mean age at BC diagnosis was 52, and 88% were diagnosed under 65. The proportion of patients with stage I, II, and III were 31.4%, 56.4%, and 12.2%, respectively. 99.6% and 63.0% received surgery and radiation therapy. Five-year DFS rates were 76.8% for TN and 89.0% for the non-TN groups (p < 0.001), while five-year recurrence rates were 18.8% for TN and 11.2% for non-TN groups (p < 0.001). The median DFS was significantly shorter for TN than non-TN patients (836 vs. 869 days, p < 0.0001). The multivariate Cox models showed that the likelihood for DFS was lower for TN (HR = 0.37, p < 0.0001), and risk for recurrence was higher for TN (HR = 2.85, p < 0.0001), as compared to non-TN group. Conclusions: Based on data from a U.S. localoncology practice, this study found TN status was associated with shorter DFS and higher risk of recurrence among early-stage BC patients despite CT. The results emphasize the need for more potent treatment for TNBC. The results need to be confirmed in other oncology practices. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration sanofi-aventis sanofi-aventis sanofi-aventis sanofi-aventis
SAT0356 Predictive Utility of Anti-Citrullinated Peptide Antibodies and Rheumatoid Factor – a Retrospective Data Analysis
Authors: M. Gärtner, M. Schneeweiss, J. Smolen, K. Machold
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Antibody profiling encompassing rheumatoid factor (RF) and anti-citrullinated peptide antibodies (ACPA) supports diagnosis in patients with Rheumatoid arthritis (RA). However, RF and ACPA are not specific for RA, and predictive values of tests depend heavily on the selection of individuals in which such tests are performed. Because testing for these antibodies is frequently ordered by non-Rheumatologists, at substantial costs, we sought to determine the predictive values of such testing in patients of a large tertiary hospital. <h3>Objectives</h3> To evaluate the positive and negative predictive values (PPV, NPV) of RF and ACPA tested in a pre-selected population of all patients of the Vienna general hospital between 2006 and 2012. <h3>Methods</h3> Results of all RF and ACPA tests performed between 2006 and 2012 were obtained from the Department of Laboratory Medicine and the ordering departments were determined. Diagnoses were extracted from the hospital-wide database. <h3>Results</h3> Between 2006 and 2012 more than 45,000 RF and ACPA tests in 5496 patients were performed. Among these, 21% were positive for RF, 3% for ACPAs and 22% were positive for both antibodies. For 2250 patients (41% of all patients in whom RF/ACPA was tested) the tests were not ordered by the Department of Rheumatology. The tests were requested by the Departments of Infectiology (32.5%), Angiology (11.1%), Orthopedics (8%), Nephrology (8%), and Dermatology (7%). 1572 of these 2250 patients had a documented diagnosis. Figure 1 shows the distribution of diseases according to the ICD-10. Among the 2250 patients 134 (6%) were positive for RF, 72 (3.2%) for ACPA and 31 (1.4%) patients tested positive for both antibodies. PPV and NPV for the presence of musculoskeletal diseases were 22.4% and 89.9% for RF and 26.4% and 88.8% for ACPA testing. However, for presence of chronic inflammatory musculoskeletal diseases (ICD-10-Codes M05.X to M09.X and M30.X to M35.X) PPV was only 11.9% for RF and 16.7% for ACPA. NPV was 95.3% and 95.2%, respectively. <h3>Conclusions</h3> RF and ACPA testing was frequently ordered by non-Rheumatologists. In this patient group, we found a relatively high NPV (95%) but a very low PPV of 11-17%. Thus, &gt;83% of positive tests did not contribute to a diagnosis of inflammatory musculoskeletal disease. This observation underscores the necessity to use such testing only in the appropriate clinical context. <h3>Disclosure of Interest</h3> None declared
An Approach to Chemically Defined Nutrients for Strain L Mouse Cells&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Philip R. White, Roscoe B. Jackson
Journal: JNCI Journal of the National Cancer Institute (1955)

An Approach to Chemically Defined Nutrients for Strain L Mouse Cells Philip R. White, Philip R. White Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar Roscoe B. Jackson Roscoe B. Jackson Memorial Laboratory, Bar Harbor, Maine Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 3, December 1955, Pages 769–787, https://doi.org/10.1093/jnci/16.3.769 Published: 01 December 1955 Article history Received: 27 May 1955 Published: 01 December 1955
The Effect of Inoculum Size on Proliferation of NCTC Strain 2071, the Chemically Defined Medium Strain of NCTC Clone 929 (Strain L)
Authors: Fioramonti, Mary C., Evans, Virginia J., Earle, Wilton R.
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article The Effect of Inoculum Size on Proliferation of NCTC Strain 2071, the Chemically Defined Medium Strain of NCTC Clone 929 (Strain L) Get access Mary C. Fioramonti, Mary C. Fioramonti Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia J. Evans, Virginia J. Evans Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle Wilton R. Earle Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 21, Issue 3, September 1958, Pages 579–583, https://doi.org/10.1093/jnci/21.3.579 Published: 01 September 1958 Article history Received: 01 April 1958 Published: 01 September 1958
Cytotoxicity of a Horse Antihuman Cancer Serum for Normal and Malignant Cells &lt;italic&gt;In Vitro&lt;/italic&gt;
Authors: Milton N. Goldstein, Raymond Hiramoto
Journal: JNCI Journal of the National Cancer Institute (1961)

By our tissue-culture techniques we have demonstrated species-specific antibodies in Björklund's horse antihuman cancer serum absorbed with human plasma. No cancer-specific lytic antibody that could not be absorbed by normal tissues was detected. Absorption studies with cancer or liver tissues removed cytolytic activity for both normal and malignant cells. If absorption was incomplete, a drop in cytotoxic activity was reflected by a delay in cell damage. When absorption was ineffective, as with skeletal muscle, brain, or plasma, lysis occurred to both normal and cancer cells. In our experiments the Sillen antiserum did not reveal a cancer-specific antibody directed against an antigen characteristic of neoplasia.
COPD (confusion over proper diagnosis) in the zone of maximum uncertainty
Authors: Philip H. Quanjer, Gregg Ruppel, Vito Brusasco, Rogelio Pérez-Padilla, Carlos A. Vaz Fragoso, Bruce H. Culver, Maureen P. Swanney, Martin R. Miller, Bruce Thompson, Mike Morgan, Mike Hughes, Brian L. Graham, Riccardo Pellegrino, Paul Enright, A. Sonia Buist, Peter Burney
Journal: European Respiratory Journal (2015)

In an excellent statement on chronic obstructive lung disease (COPD) that focuses on questions that are relevant for the patient's well-being and quality of life [1, 2], one issue should have received more critical attention. For research into COPD, it is vital that the diagnosis of airway obstruction, which traditionally hinges on a forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio below a threshold, can be accurately established. Celli et al . [1, 2] state that this threshold is uncertain, leaving the recommendations open ended to some extent. They refer to the discussion whether in ascertaining a diagnosis of COPD the threshold for the FEV1/FVC ratio should be the lower limit of normal (LLN), defined in respiratory medicine as the 5th centile in a representative sample of healthy nonsmokers, or the post-bronchodilator FEV1/FVC of 0.7 first proposed in 2001 by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) group [3]. The latter threshold has not been clinically validated; it was intended to simplify recognition and increase awareness of COPD, particularly in less developed countries where the LLN might not be presented with the test results. The use of the fixed ratio has been extensively criticised. Cross-sectional data show that it leads to underestimating the prevalence of airflow limitation in younger people and to large overestimates in those older than 45 years. In 80-year-old healthy subjects, this leads to a 75–80% false positive rate [4]. The Burden of Obstructive Lung Disease (BOLD) group also routinely uses the LLN cut-off for reporting the prevalence of abnormal ventilatory function [5]. Follow-up studies have shed light on the question of whether observations in the zone between the fixed ratio and LLN represent respiratory disease. In asymptomatic subjects and very elderly subjects, an FEV1/FVC above the LLN but below 0.7 was not associated with premature death [6–10], an abnormal decline in FEV1 [11–13], respiratory care use [11], hospitalisation [10] or quality of life [11]. Conversely, an FEV1/FVC ratio below the LLN is associated with increased risk of hospitalisation [10] and mortality [8–10, 12, 13]. Three reports [9, 16, 17] suggested that use of the LLN cut-off would miss individuals at risk, but these findings have been contested [18–21]. A A fixed cut-off in FEV1/FVC ratio is not an appropriate measure for diagnosing COPD <http://ow.ly/RZyLe>
The Production of Hemorrhage in Sarcoma 180 in Mice by Anaphylaxis and the Inhibitory Effect of Cortisone on the Hemorrhage-Producing Factor from &lt;italic&gt;E. coli&lt;/italic&gt;&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: D H CAMPBELL, R S FARR, H RINDERKNECHT
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article The Production of Hemorrhage in Sarcoma 180 in Mice by Anaphylaxis and the Inhibitory Effect of Cortisone on the Hemorrhage-Producing Factor from E. coli Get access Dan H. Campbell, Dan H. Campbell Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard S. Farr, Richard S. Farr Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Rinderknecht H. Rinderknecht Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 6, June 1955, Pages 1651–1655, https://doi.org/10.1093/jnci/15.6.1651 Published: 01 June 1955 Article history Received: 08 September 1954 Published: 01 June 1955
Left prefrontal glucose hypometabolism in the depressed state: a confirmation
Authors: J L Martinot, P Hardy, A Feline, J D Huret, B Mazoyer, D Attar-Levy, S Pappata, A Syrota
Journal: American Journal of Psychiatry (1990)

The resting-state cerebral metabolic rates for glucose of 10 severely depressed patients (seven bipolar and three unipolar) were compared, before and after treatment with tricyclic antidepressants, to those of 10 control subjects of similar age by means of positron emission tomography and the fluorodeoxyglucose method. Significant left-right prefrontal asymmetry was present in the patients before but not after successful treatment, suggesting that medication can reduce this asymmetry. Also, significant hypofrontality and whole-cortex hypometabolism were found in the patients in the depressed state and persisted in the treated state, despite clinical improvement, suggesting that these abnormalities are not state dependent.
Former medical director faces claims that he failed to act over concerns about doctor
Authors: Clare Dyer
Journal: BMJ (2016)

The medical director of an NHS trust repeatedly failed to take action to protect patients from the risk of harm posed by a bungling consultant obstetrician and gynaecologist, the General Medical Council has alleged.

In a hearing that opened on 6 June and is listed to finish on 1 July, Paul Upton is accused of having not properly investigated or intervened from January 2010 to October 2011 as concerns mounted over the practice of Rob Jones.1

The case is thought to be the first action by the regulator to go to a hearing that focuses on a doctor’s managerial role rather than on his clinical practice. A spokeswoman …
Clinical characteristics and response to sodium lactate of patients with infrequent panic attacks
Authors: D S Cowley, S R Dager, S I Foster, D L Dunner
Journal: American Journal of Psychiatry (1987)

Nine patients with panic attacks too infrequent to meet DSM-III criteria for panic disorder were compared to 20 panic disorder patients with respect to clinical characteristics and response to sodium lactate infusion. The two groups showed similar clinical characteristics and response to lactate. The authors conclude that patients with infrequent panic attacks are clinically and biologically similar to those with panic disorder and discuss implications for the diagnosis of panic states.
A phase II study (ARCHER 1042) to evaluate prophylactic treatment of dacomitinib-induced dermatologic and gastrointestinal adverse events in advanced non-small-cell lung cancer
Authors: M.E. Lacouture, D.M. Keefe, S. Sonis, A. Jatoi, D. Gernhardt, T. Wang, J.P. Doherty, N. Giri, S. Nadanaciva, J. O'Connell, E. Sbar, B. Piperdi, E.B. Garon
Journal: Annals of Oncology (2016)
Anticipatory Nausea and Vomiting Associated with Cancer Chemotherapy
Authors: W W Weddington, N J Miller, D L Sweet
Journal: New England Journal of Medicine (1982)

Fifty adult oncology outpatients receiving chemotherapy were surveyed to assess their experiences with chemotherapy-associated nausea and vomiting. Of patients who noted post-chemotherapy nausea with or without vomiting, 46% reported anticipatory nausea. The anticipatory symptoms developed after the onset of post-chemotherapy neausea. Patients experiencing anticipatory symptoms had received chemotherapy over a significantly longer period of time than had the patients with post-treatment nausea only. Of these patients who had noted post-chemotherapy nausea with or without vomiting for two or more months, 50% reported pre-treatment nausea with or without vomiting. There was no tendency toward anticipatory symptoms according to age, sex, race, educational level, disease, or type of chemotherapy. Thoughts of chemotherapy, sights, specific odors and tastes evoked anticipatory symptoms. Pre-treatment or anticipatory nausea and vomiting are probably a manifestation of classical (Pavlovian) conditioning.
Influence of Age on Wound Healing
Authors: W Doberauer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Life Events, Coping, Stress, and Depressive Symptomatology
Authors: George J. Warheit
Journal: American Journal of Psychiatry (1979)

The author presents data on the relationships between life events, coping resources, and depressive symptomatology. A probability sample (N =517) was interviewed three years apart. Respondents with high life-event scores had significantly more depressive symptomatology than those with low scores. Those with personal, familial, and interpersonal resources had significantly less depressive symptomatology than those without such resources in both the low- and high-life-event groups. The best predictor of Time 2 depressive symptom scores was Time 1 symptom scores; losses and resources were also statistically significant factors. These findings demonstrate the complex interrelatedness of life events, coping resources, and depressive symptomatology.
Identifying the Appropriate FISH Criteria for Defining MET Copy Number–Driven Lung Adenocarcinoma through Oncogene Overlap Analysis
Authors: Sinéad A. Noonan, Lynne Berry, Xian Lu, Dexiang Gao, Anna E. Barón, Patrick Chesnut, Jamie Sheren, Dara L. Aisner, Dan Merrick, Robert C. Doebele, Marileila Varella-Garcia, D. Ross Camidge
Journal: Journal of Thoracic Oncology (2016)
Surgical Treatment
Authors: Langdon Parsons
Journal: JAMA (1965)

Modern therapy for cervical cancer embraces the concept of individualization. No longer is it necessary for the patient to conform to a standard pattern of treatment. It is not a question of whether radical surgery or irradiation is better treatment for cervical cancer, but rather what is best for the individual. Within the scope of individualization in therapy, surgery has a logical place in the treatment of cancer of the cervix. Unfortunately, the discussions of the relative merits of surgery or irradiation to cure cancer of the cervix have become so tinged with emotion that the physician is hopelessly confused. He does not know (1) when he should advise surgery, (2) what the limitations of surgery are, or (3) how extensive the surgery needs to be to expect a cure. The Wertheim type of abdominal hysterectomy and pelvic lymph node dissection, as well as the SchautaAmreich radical vaginal hysterectomy combined
Response of Mammary-Tumor-Agent-Free Strain DBA Female Mice to Percutaneous Application of Methylcholanthrene
Authors: H B ANDERVONT, T B DUNN
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article Response of Mammary-Tumor-Agent-Free Strain DBA Female Mice to Percutaneous Application of Methylcholanthrene Get access Howard B. Andbrvont, Howard B. Andbrvont biologist Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn Thelma B. Dunn pathologist National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 4, February 1950, Pages 895–925, https://doi.org/10.1093/jnci/10.4.895 Published: 01 February 1950 Article history Received: 17 November 1949 Published: 01 February 1950
PTU-249 Outcomes of emergency colorectal surgery in district general hospital
Authors: R Mcbride, C Magee, K Mulholland
Journal: Gut (2015)

<h3>Introduction</h3> Emergencies make up greater than one third of all general surgical admissions with many of these patients being elderly with significant co-morbidities. Mortality in this group is high, varying from 15–25%. Concerns over the quality of emergency surgical care prompted the formulation from RCS: Standards for unscheduled care. Using the standards set by this guideline, the practice in a DGH was audited. Primary focus was consultant presence in cases with predicted mortality &gt;10%. <h3>Method</h3> Theatre Management System from 01/09/12–31/07/13 identified all emergency laparotomies. All cases were reviewed and elective, non-colorectal and re-laparotomies were excluded. Patient charts were reviewed and a predicted perioperative mortality (Portsmouth-POSSUM score) calculated. Specific outcomes included consultant presence, procedure performed, post-operative level of care and complications. <h3>Results</h3> In total 188 laparotomies were identified with 40 emergency colorectal cases. The mean age was 74 years with a male to female ratio of 45:55. Sepsis was the indication in 58% of cases. The mean P-POSSUM was 29.85% (range 1–87) with an observed 30 day mortality of 30%. Benign pathology accounted for 65% of cases with maliganacy the remaining 35%. Patients operated on a Saturday and Sunday had a mortality of 50–60% with the remainder of the week between 14–25%. Time of day also had an affect on mortality as, whilst only 20% of patients were operated on after midnight, mortality was 50%. In comparison 53% were operated during normal working hours (8 am–5 pm) with a morality of 24%. A consultant surgeon was present at 80% of all cases, with 76% present at those with a P-POSSUM &gt;10%. Consultant anaesthetist was present at 62.5% and 64% respectively. For patients who died a consultant anaesthetist was only present at 40% of these cases with surgeon at 75%. Neither surgeon nor anaesthetist was present at 25% of these cases. <h3>Conclusion</h3> Emergency laparotomy for acute colorectal pathology carries a high morbidity and mortality. In 35% of patients this was an acute presentation of colorectal cancer. Our results are broadly comparable with national figures and consultant presence was generally good. There was a trend towards reduced mortality when present, in particular anaesthetic presence. Use of a tool, such as P-POSSUM may help to highlight cases which would benefit from consultant level anaesthetic and surgical input. A regionally agreed emergency surgery checklist may help guide critical care referral and senior review. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Royal College of Surgeons: Emergency surgery, standards for unscheduled care, February 2011 NELA: Organisational Report of the National Emergency Laparotomy Audit, May 2014