tbuckley/cabot-search huggingface dataset:
PTH-014 Bowel scope screening programme; depth of insertion and withdrawal times vs adenoma detection rate: Abstract PTH-014 Table 1
Authors: R Warburton, U Meagher, A Field, R Tighe
Journal: Gut (2015)

<h3>Introduction</h3> The Norwich bowel cancer screening centre was one of the initial pilot sites for launch of the Bowel scope screening programme commencing in May 2014. One key performance indicator of Bowel scope screening programme is the adenoma detection rate (ADR), and concern has been expressed that low ADRs reflect missed adenomas and therefore may reduce the beneficial effect of the programme. Nationally, there has been variation in adenoma detection rates between both individual endoscopists and the pilot screening centres. Speculation has been made that the depth of insertion of the endoscope may negatively correlate with ADR, possibly as less time is available for close inspection of the colonic mucosa on withdrawal. <h3>Method</h3> We have analysed data on BCSS from the last 18 months derived from the Norwich screening centre. A total of 11 endoscopists have performed more than 50 bowel scope procedures each, totalling 4824 over the 18 months with an ADR of 9.14%. The procedures were stratified by depth of insertion and examined for ADR and withdrawal times. <h3>Results</h3> Passage of the endoscope to the splenic flexure was associated with a higher ADR compared with passage to the sigmoid colon (9.94% Splenic Flexure; 9.09% Transverse Colon; 5.49% Sigmoid Colon) (X<sup>2 </sup>4.72; p = 0.03). Passage of the endoscope only to the rectum was associated with a very high ADR (32.14%) – presumably because the procedure was stopped because a large polyp was identified (Table 1). Passage of the endoscope to the splenic flexure was associated with a longer withdrawal time compared with passage to the sigmoid colon (3.4 min for Splenic Flexure; 3.6 min for Transverse Colon and 2.1 min for Sigmoid Colon). The data for individual endoscopists was also analysed by percentage passage of the endoscope to the splenic flexure, individuals’ ADR and individuals’ withdrawal times. There was no correlation between the ADR and either percentage passage to the splenic flexure or the individuals’ overall withdrawal times. <h3>Conclusion</h3> The depth of insertion of the endoscope correlates positively with higher ADR, and is not associated with shorter withdrawal times. It is likely that individual lesion recognition skills of the endoscopist are responsible for the variations in ADR seen within Bowel Scope. <h3>Disclosure of interest</h3> None Declared.
Management of stage I-II Hodgkin's disease in children.
Authors: B G Leventhal
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.7.1123 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2193115 Management of stage I-II Hodgkin's disease in children. B G LeventhalxB G LeventhalSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.7.1123 PDF "Management of stage I-II Hodgkin's disease in children.." Journal of Clinical Oncology, 8(7), pp. 1123–1124© 1990 by American Society of Clinical Oncology
Myelogenous Leukemia in the Cat
Authors: Willard Halset Eyestone
Journal: JNCI Journal of the National Cancer Institute (1951)

Myelogenous Leukemia in the Cat Willard Halset Eyestone Willard Halset Eyestone Pathology Section, National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 3, December 1951, Pages 599–613, https://doi.org/10.1093/jnci/12.3.599 Published: 01 December 1951 Article history Received: 17 September 1951 Published: 01 December 1951
Malnutrition and cancer.
Authors: I D Johnston, P D Wright, T W Lennard, M B Clague, M J Carmichael, D M Francis, R H Williams
Journal: BMJ (1979)

Griffith Edwards has rightly observed that alongside our declared medical approach to drug dependence is a penal response to the problem-to a considerable but hidden extent.Both the size and the desirability of this development need examination and debate.
PWE-299 Evaluation of wound infusion catheters as analgesia in elective and emergency colorectal surgery
Authors: C Mann, D Couch, A Roberts, A Packham, J Tring, A Miller
Journal: Gut (2015)

<h3>Introduction</h3> Wound infusion catheters are becoming increasingly popular to control post-operative pain as an alternative to thoracic epidurals, which have a significant failure rate and complication profile. The aim of this was to review our experience with the OnQ® (Bbraun) wound infusion catheter in patients undergoing elective and emergency colorectal laparotomy in terms of usage, safety and efficacy. <h3>Method</h3> Retrospective analysis of a prospectively maintained database of all patients undergoing elective and emergency colorectal laparotomy at Leicester Royal Infirmary October 2013–2014. Emergency patients ventilated post-operatively were excluded. OnQ® wound catheters were inserted in the preperitoneal plane in combination with morphine PCA, and delivered levobupivicaine 0.25% 5 ml/hr for 56 h. <h3>Results</h3> Since 2008, 727 patients have received wound catheters as analgesia following colorectal laparotomy. Complication rate was low (1.5%), mainly related to catheter displacement (n = 11). During the 12 month study period 179 patients underwent elective colorectal laparotomy. 120 of these had an OnQ® inserted (67%), with a significantly lower total morphine consumption compared to PCA alone (109 vs 193 mg p &lt; 0.05 Mann-Whitney). 239 patients underwent emergency laparotomy during this period. Of these, only 28 had an OnQ® inserted (11%), again with a significantly lower total morphine consumption compared to PCA alone (92 vs. 154 mg p &lt; 0.05 Mann-Whitney). The only complications directly related to the OnQ® during this period were due to catheter displacement (n = 2). <h3>Conclusion</h3> Wound infusion catheters are safe, effective and simple to use. They are a good addition to multimodal analgesia in patients undergoing elective colorectal laparotomy. They are equally effective in patients undergoing emergency laparotomy, however are considerably under-used - an area which will be addressed. <h3>Disclosure of interest</h3> None Declared.
Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice
Authors: Jingchun Liu, Manjula Santhanakrishnan, Prabitha Natarajan, David R. Gibb, Stephanie C. Eisenbarth, Christopher A. Tormey, Alexa J. Siddon, Sean R. Stowell, Donald R. Branch, Jeanne E. Hendrickson
Journal: Blood (2016)
DSM-IV: a nosology sold before its time?
Authors: M Zimmerman, V C Jampala, F S Sierles, M A Taylor
Journal: American Journal of Psychiatry (1991)

The purpose of this study was to determine whether American psychiatrists believe that DSM-IV is being published too soon after DSM-III-R.The authors conducted a mail survey of the attitudes of practicing psychiatrists (N = 454), residency program directors (N = 128), residents (N = 1,331), and researchers (N = 196) toward the scheduled publication of DSM-IV in the early 1990s.They found that the majority of all four groups believed that DSM-IV is being published prematurely. In contrast to respondents who believed that the timing of DSM-IV is appropriate, those who indicated that it is being published too soon had more recently completed their residency training and also believed that DSM-III-R was published prematurely. There was no association between the psychiatrists' responses and their theoretical orientation, Board certification status, ownership of the DSM manuals, the length of time they had used DSM-III, and the diagnostic manual (DSM-III or DSM-III-R) they were currently using.The belief that DSM-IV is being published too soon could contribute to underuse of DSM-IV by substantial numbers of psychiatrists. Thus, to foster compliance with it, APA must preserve in its efforts to demonstrate that the advantages of publishing it in 1993 outweigh the disadvantages of adopting yet another manual.
Case 34-1964
Authors: G. B. Clifton Harris, Robert E. Scully
Journal: New England Journal of Medicine (1964)

Presentation of CaseA four-day-old male infant was admitted to the hospital because of respiratory distress.The child had been born five weeks before term; the birth weight was 7 pounds, 9 ounces. Immediately after birth respiratory distress developed, and oxygen was given. Four days later x-ray examination revealed emphysema of the right lung.During the pregnancy the mother had had an excessive gain in weight and intermittent glycosuria; a glucose tolerance test performed during the pregnancy had been negative.Physical examination revealed a jaundiced child who became mildly cyanotic without supplemental oxygen. The trachea was shifted to the left. . . .
ANTICOAGULATION IN CEREBROVASCULAR DISEASE
Authors: R B Butler
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Efficiency of Extracorporeal Shockwave Lithotripsy on Calcium-Oxalate Stones: Role of Copper, Iron, Magnesium and Zinc Concentrations on Disintegration of the Stones
Authors: Sadettin Küpeli, Nihat Arikan, Ilker Durak, Kemal Sarica, Mustafa Akpoyraz, Giray Karalezli
Journal: European Urology (1993)
SP0177 Linking Vasculopathy and Fibrosis
Authors: M. Trojanowska
Journal: Annals of the Rheumatic Diseases (2015)

The hallmark features of SSc include fibroproliferative vasculopathy, immune dysfunction, and extensive skin and organ fibrosis. Delineation of the common pathways responsible for the pathological changes affecting the key disease cell types would be critical to developing effective therapeutic strategies. Extensive clinical and experimental evidence implicate alterations of transcription factor Fli1 (Friend leukemia integration-1) in disease pathogenesis. Fli1 deficiency contributes to the induction of SSc-like phenotypic changes in dermal fibroblasts, endothelial cells and macrophages in a manner consistent with human disease. Thus, restoring the Fli1 levels in diseased tissues may represent a valid therapeutic strategy to treat SSc. Elucidation of factors that contribute to Fli1 deficiency in SSc will be essential to fully implement this strategy. This presentation will discuss the progress in characterizing such factors and potential therapeutic strategies to restore Fli1 levels. <h3>Disclosure of Interest</h3> None declared
Computerised vaccination register for the Murcia region, Spain, 1991 to 2011
Authors: P J Bernal-González, J A Navarro-Alonso, J J Pérez-Martín
Journal: Eurosurveillance (2012)

We describe the Murcia regional vaccination register in Spain, which was set up in 1991, detailing its main features, advantages and limitations. We also report on some recent special actions carried out that led to an improvement in vaccination coverage against measles, rubella and mumps (MMR): by using the vaccination register, we were able to identify and vaccinate persons aged under 20 years in a measles outbreak in 2010 in the town of Jumilla who were not adequately vaccinated for their age with MMR vaccine. From spring 2012, use of our register will enable us to identify susceptible individuals in our region under 40 years of age who have received fewer than two doses of MMR vaccine and call them for the appropriate vaccination. We also set out our experience in the use of barcodes to identify individuals and collect vaccine data: our data show that the barcodes help to improve data quality and completeness. Finally, we identify certain challenges in search of greater standardisation for systems and encoding that is necessary to enable an easy exchange of data between different registers.
Salivary and Urine Theophylline Levels in Management of Childhood Asthma
Authors: S J Goldsworthy, M Kemp, J O Warner
Journal: Journal of the Royal Society of Medicine (1981)

It is not possible to predict the plasma theophylline levels that can be achieved using slow-release aminophylline based on body weight or surface area. Improvement in FEV 1 is directly related to increasing serum theophylline level, justifying the need for measuring levels in order to optimize therapy. As repeated venesection in children is unpleasant we have studied a simple method using saliva. Simultaneous blood and salivary theophylline levels correlated sufficiently well for salivary levels to be used for monitoring purposes. Urine levels did not correlate as well, but could be used for checking compliance.
Observations on Properties of Leukemic Cells Resistant to Folic Acid Antagonists
Authors: L. W. Law, Mr. Peter J. Boyle
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Observations on Properties of Leukemic Cells Resistant to Folic Acid Antagonists Get access L. W. Law, L. W. Law Search for other works by this author on: Oxford Academic PubMed Google Scholar Mr. Peter J. Boyle Mr. Peter J. Boyle technical assistance National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 4, February 1951, Pages 849–865, https://doi.org/10.1093/jnci/11.4.849 Published: 01 February 1951 Article history Received: 11 December 1950 Published: 01 February 1951
AB0859 Is There a Relationship Between Sarcopenia, Obesity and Radiographic Severity of Knee Osteoarthritis?
Authors: L. Medrare, A. Ngeuleu, A. Mahdi, I. Benslama, T. Lakhdar, H. Rkain, F. Allali, N. Hajjaj-Hassouni
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> The purpose of this study was to analyze the association between the radiographic severity of knee osteoarthritis (OA) and 4 different categories of body composition: normal, sarcopenic nonobesity, nonsarcopenic obesity, and sarcopenic obesity <h3>Methods</h3> This was a cross-sectional study using the data from 73 participants with primary knee osteoarthritis ACR criteria. Information on demographics, comorbidities and medication was gathered. Anthropometrical measurements included weight, height and waist circumference. Radiographic knee OA was performed in all patients (based on the classification of kellgren- lawrence). Appendicular skeletal muscle mass (ASM) and whole-body fat mass were measured using dual x-ray absorptiometry. Sarcopenia was defined as a skeletal muscle mass index =ASM/height<sup>2</sup> &lt;1.55kg/m<sup>2</sup> in women and &lt;7.26 kg/m<sup>2</sup> in men according to Baumgartner anthropometric equation. <h3>Results</h3> 73 patients were included with a mean age of 61.87±3.93 years with a female predominance (95.9%), the median disease duration was 48 month [21-78].The prevalence of each body composition category was as follows: 38.4% normal, 35.4% nonsarcopenic obesity, 4.1% sarcopenic nonobesity, and 4.2% sarcopenic obesity. In univariate analysis, compared with nonsarcopenic obesity participants, participants with sarcopenic obesity were significantly older, had lower ASM, higher whole-body fat mass, and higher waist circumference. However, there was no significant difference in body weight or BMI. In multivariate analysis, sarcopenic obesity was more closely associated with radiographic severity of knee OA than was nonsarcopenic obesity. Sarcopenic nonobesity showed no significant association with knee OA. <h3>Conclusions</h3> Sarcopenic obesity was more closely associated with radiographic severity of knee OA than was nonsarcopenic obesity, although both groups had equivalent body weight. This finding supports the importance of the systemic metabolic effect of obesity in knee OA <h3>Disclosure of Interest</h3> None declared
PTU-040 Colon capsule transit times and image quality in patients prepared with polyethylene glycol+ascorbate (peg+a) and booster of either peg+a or gastrografin and low dose sodium phosphate (NAP): Abstract PTU-040 Table 1
Authors: D Nastou, H Palmer, J Lewandowski, O Epstein
Journal: Gut (2015)

<h3>Introduction</h3> Successful colon capsule endoscopy (CCE) requires high capsule excretion rates and high quality bowel cleansing. Cleansing regimens are based on polyethylene glycol (PEG) supplemented with a booster of NaP to accelerate transit time. Because preparation with NaP is rarely associated with renal toxicity, we have piloted two novel CCE cleansing regimens in patients at low risk of NaP nephrotoxicity. <h3>Method</h3> <i>Prep 1</i>was designed as a NaP free regimen comprising 2L split dose PEG+Ascorbate (PEG+A) with an additional 1L booster after capsule ingestion. <i>Prep 2</i>comprised identical split dose 2L PEG+A, but the post capsule ingestion booster comprised of low dose NaP (30–45 ml) and gastrografin (50–100 ml).34 CCEs were reviewed, 17 from each group. Oro-caecal, caeco-rectal transit times and capsule excretion rates were measured. Quality of bowel cleansing was assessed by two independent observers, using a modified small bowel cleansing scale grading from the first caecal image and every 15 mins until the end of the study. At each time point the assessors graded each of the two static images recorded by the CCE cameras. The proportion of visualised mucosa was graded as M3 (&gt;75% of mucosal surface visualised), M2 (50–75%), M1 (25–49%) and M0 (&lt;25%). Obscuration was graded as O3 (&lt;5% of the image obscured by bubbles, debris or unclear fluids), O2 (5–24%), O1 (25–50%) and O0 (&gt;50%). If capsule remained stationary &gt;15 mins, the time was extended to the frame 15 mins following onward movement of capsule. <h3>Results</h3> Mean oro-caecal and caeco-rectal transit times and excretion times (h:mm) were 4:06,2:59 and 6:31 for <i>Prep 1 </i>and 3:06, 2:07 and 5:17 for <i>Prep 2. </i>Excretion rates for <i>Prep 1</i>and <i>Prep 2 </i>were 35.3% and 88.2% respectively. Table 1indicates the percentage of the examined frames for each score for mucosal surface visualisation and for obscuration. <h3>Conclusion</h3> <i>Prep 1 </i>assessed whether a PEG+A booster could produce a “tsunami” prokinetic and cleansing effect and <i>Prep 2 </i>examined boosting with a combination of gastrografin and low dose NaP. Failure of capsule excretion occurred in almost two thirds <i>of Prep 1 </i>patients, whilst with <i>Prep 2</i>the 88.2% completion rate was similar to that expected in standard colonoscopy. In <i>Prep1 </i>group 55% of frames examined scored M2/M3 for mucosal visualisation and 43% O2/O3 for obscuration, in <i>Prep 2</i>group 82% of frames scored M2/M3 and 72% O2/O3. PEG+A is an ineffective booster and fails to achieve adequate cleansing whilst the booster combination of gastrografin and low dose NaP appears to offer excellent excretion rates and enhanced bowel cleansing. <h3>Disclosure of interest</h3> None Declared.
The Black Patient and Research in a Community Mental Health Center: Where Have All the Subjects Gone?
Authors: Brian L. Weiss, David J. Kupfer
Journal: American Journal of Psychiatry (1974)

The virtual absence of blacks on psychiatric research wards has been reported previously. This paper attempts to explain this phenomenon with observations made at the Yale-Connecticut Mental Health Center, a center with a very active research program that is located near a large ghetto in New Haven. The authors identify three pertinent factors: the attitudes of the center staff toward black patients, the attitudes of the black patients toward the white-dominated research staff, and the attitudes toward blacks and other minorities embedded in the structure and practices of the institution. They conclude that these factors must be dealt with if psychiatric research is to be generalizable to all segments of the population.
Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960–2013
Authors: Megan L. Krause, Cynthia S. Crowson, C. John Michet, Thomas Mason, Theresa Wampler Muskardin, Eric L. Matteson
Journal: Arthritis & Rheumatology (2015)

Objective To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994–2013 and trends in juvenile rheumatoid arthritis (JRA) in 1960–2013. Methods Cases of arthritis in 1994–2013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population. Comparisons were made with an earlier (1960–1993) cohort from this same population. Results Seventy‐one incident cases of JIA in 1994–2013 were identified, with an overall age‐ and sex‐adjusted incidence rate of 10.3 per 100,000 (95% CI 7.9–12.7). Forty‐two (59%) were female, with an incidence of 12.4 per 100,000 (95% CI 8.6–16.2), as compared to 8.3 per 100,000 (95% CI 5.2–11.3) in males. The most common subtype was oligoarthritis (63%). The mean ± SD age at diagnosis was 8.2 ± 5.3 years. The prevalence of JIA on January 1, 2000 and January 1, 2010 was 51.0 per 100,000 (95% CI 25.2–76.8) and 57.6 per 100,000 (95% CI 31.0–94.5), respectively. When the annual incidence of JRA was compared over time from 1960 to 2013, there was no significant change in incidence overall; however, the incidence decreased among females ( P = 0.003). A cyclic pattern of incidence was observed, with peaks approximately every 10 years. Similar to the findings with regard to incidence, prevalence did not change overall, but decreased among females ( P = 0.048). There were 4 deaths in the cohort of JRA patients diagnosed in 1960–2013; the standardized mortality ratio was 1.50 (95% CI 0.41–3.83). Conclusion Incidence of juvenile arthritis overall in Olmsted County, Minnesota has not changed significantly in the past 53 years. A consistent cyclic pattern was noted.
Tumor Development in Backcross Mice Segregated with Respect to the Hairless and the Pink-Eye Genes
Authors: W. E. Heston, Margaret K. Deringer
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Tumor Development in Backcross Mice Segregated with Respect to the Hairless and the Pink-Eye Genes Get access W. E. Heston, W. E. Heston National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer Margaret K. Deringer National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 2, October 1951, Pages 361–366, https://doi.org/10.1093/jnci/12.2.361 Published: 01 October 1951 Article history Received: 25 May 1951 Published: 01 October 1951