tbuckley/cabot-search huggingface dataset:
The prognostic value of nadir testosterone levels in prostate cancer patients treated with combined androgen blockade in Japanese men.
Authors: Shinichi Sakamoto, Shuhei Kamada, Koji Kawamura, Naoki Nihei, Takashi Imamoto, Yukio Naya, Koichiro Akakura, Hiroyoshi Suzuki, Tomohiko Ichikawa
Journal: Journal of Clinical Oncology (2015)

e16049 Background: The most clinically significant castration level during androgen deprivation therapy (ADT) remains controversial. Moreover, no past studies demonstrated the prognostic impact of nadir testosterone (TST) levels on Combined Androgen Blockade (CAB). The present study examined the clinical significance of nadir TST levels in predicting the prognosis of prostate cancer patients treated with CAB in Japanese Men. Methods: A total of 225 patients who underwent CAB as 1st-line therapy for prostate cancer at Chiba University Hospital and its affiliated hospital (1999-2014) were retrospectively analyzed. The prognostic values of the serum TST levels and other clinical factors were evaluated in association with PSA progression-free survival (PFS) and overall survival (OS). Cox hazard proportional models and the Kaplan-Meier method were used for statistical analysis. Results: The patients’ average age was 72.3 years. The median PSA was 42.6 ng/mL. The average follow-up was 32.7 months. No variable associated with TST was predictive of PFS. With regard to OS, on univariate analysis, nadir TSTs of 20, 32 ng/dL were significant prognostic factors together with other clinical factors including PSA. In contrast, nadir TST 8 ng/dL was not significant. Multivariate analysis showed that the most significant prognostic factor was nadir TST of 20 ng/dL (p = 0.0004). Although the lowest nadir TST < 8 ng/dL was not a significant prognostic factor for OS, patients who achieved a lower nadir TST survived longer. In addition, time to nadir TST was 344 days (median), then we divided patients into rapid type and slow type, based on time to TST 20 ng/dL before and after 6 months, respectively. No significant difference in OS was observed between two types. The present results indicate that the critical factor for prognosis was not a rapid decrease, but rather the absolute decrease of the TST levels. Conclusions: Nadir TST of 20 ng/dL was the most significant prognostic factor for OS in patients treated with CAB, but Nadir TST of 8 ng/dL was not the siginificant factor. Interestingly enough, the time needed to reach the nadir TST was about 1 year, suggesting the importance of long-term serum TST testing.
Antibiotic-sensitivity Tests
Authors: J D GRAY
Journal: BMJ (1965)

Ampicillin for Sore Throat SIR,-Dr. A. A. Robertson's conclusion (9 June, p. 614) that the use of ampicillin must be considered in the treatment of acute sore throats is based on the following premises: (l)-that Haemophilus influenzae is fre-
Soundings: The good doctor
Authors: Liam Farrell
Journal: BMJ (2002)

How do you define the good doctor? How do you solve a problem like Maria? Being kind and compassionate is all very well but we need more, the rage to achieve, the pride not to accept defeat; like Milton's Satan, our vices are indistinguishable from our virtues. The qualities demanded are multiple, and they fluctuate with time and circumstances.
Letters
Authors: Robert L. Carolla
Journal: Annals of Internal Medicine (2015)

On Being a Doctor7 July 2015LettersRobert L. Carolla, MDRobert L. Carolla, MDFrom CoxHealth, Springfield, Missouri.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M14-2884 Audio Reading - “Letters” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Letters," by Robert L. Carolla. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail After my mother's death and many years after I had been in practice, I was going through her papers and found in the drawer of her bedside table the letter that a physician had written to her 50 years earlier. It was wrinkled, with frayed edges and fingerprints, betraying much reading and rereading. It had lain next to her as she slept for more than 50 years.How many letters are saved for 50 years? Among the scraps of paper that we have saved, what can be found there and what colossal importance do they represent?My brother was born ... Author, Article, and Disclosure InformationAffiliations: From CoxHealth, Springfield, Missouri.Corresponding Author: Robert L. Carolla, MD, CoxHealth, 2916 East Alpine Drive, Springfield, MO 65804; e-mail, robert.[email protected]com. PreviousarticleNextarticle Advertisement Audio Reading - “Letters” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "Letters," by Robert L. Carolla. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetailsSee AlsoLetters Jennifer R. Hartmark-Hill Letters Robert L. Carolla Metrics Cited byLettersJennifer R. Hartmark-Hill, MD 7 July 2015Volume 163, Issue 1Page: 66KeywordsBloodDrugsEmotionsHematology and oncologyHospitalizationsMethotrexateOutpatientsPatientsPrecursor cellsSepsis ePublished: 7 July 2015 Issue Published: 7 July 2015 Copyright & PermissionsCopyright © 2015 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
ClearCell FX Microfluidic System for the Enrichment and Genetic Analysis of Circulating Tumor Cells.
Authors: Sohan Lal Punia, LIntao Bi, Mehmet Akif Turker, Jin Sung Jang, Michael B Campion, Jesse S Voss, Benjamin Kipp, Axel Grothey, Lisa A. Boardman, Dennis A. Wigle, Kevin C Halling, Minetta C. Liu, Jin Jen
Journal: Journal of Clinical Oncology (2015)

e22023 Background: Increasing evidence suggests that the enumeration and gene mutations associated with CTCs will provide a non-invasive means for individualizing cancer therapy, assessing prognosis, and treatment monitoring. ClearCell FX is a semiautomated microfluidics system that utilizes the biomechanical differences between tumor and non-tumor cells to isolate intact viable CTCs for cell enumeration and downstream molecular analyses. Methods: We evaluated the performance of ClearCell FX using spiked-in cancer cells H1299 and MCF7 in normal control blood. We also compared the performance of ClearCell FX to CellSearch using parallel blood samples from patients with advanced breast and colorectal cancers. Isolated CTCs from patients with early resectable lung cancer and metastatic colon and breast cancer are examined by immunofluorescence (IF) staining, fluorescence in situ hybridization (FISH), next generation sequencing (NGS) with the Ion AmpliSeq hotspot cancer panel, and whole exome sequencing. Results: ClearCell FX system provided up to 80% cell recovery after a single (1x) run. Recoveries were 60-70% after a second enrichment (2x) run. The rate of recovery was linear from 10-5000 cells and consistent for both lung and breast cancer cells (H1299 and MCF-7 cells, R2 = .988). Cell purity was less than 1% after 1x run but increased to 1-40% with the 2x protocol thus making it clinically feasible for downstream molecular analyses. The sensitivity to detect tumor specific mutations in CTCs by NGS in the ClearCell enriched sample was as low as 3 cells per ml of blood. NGS analyses of 2x enriched CTCs using clinical samples have so far detected missense variants in the SMO, CDH1 and MET genes. Conclusions: We validated the ClearCell FX system for robust, low-cost and label-free enrichment of CTCs. Our data shows that the cells recovered are suitable for IF and FISH and that the relatively high purity of the 2x run samples are readily usable for downstream NGS analyses. Disclosure Declaration: This work is supported by a collaborative research agreement with ClearBridge BioMedics.
Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia
Authors: Hagop M. Kantarjian, Daniel J. DeAngelo, Matthias Stelljes, Giovanni Martinelli, Michaela Liedtke, Wendy Stock, Nicola Gökbuget, Susan O’Brien, Kongming Wang, Tao Wang, M. Luisa Paccagnella, Barbara Sleight, Erik Vandendries, Anjali S. Advani
Journal: New England Journal of Medicine (2016)

The prognosis for adults with relapsed acute lymphoblastic leukemia is poor. We sought to determine whether inotuzumab ozogamicin, an anti-CD22 antibody conjugated to calicheamicin, results in better outcomes in patients with relapsed or refractory acute lymphoblastic leukemia than does standard therapy.
Blood Donation
Authors: Janet M. Torpy
Journal: JAMA (2008)

Blood DonationB lood is a living tissue made up of blood cells, platelets, and a fluid called plasma that contains protein and a number of other components.A blood transfusion is the administration of blood or blood components directly into the bloodstream.Every year, more than 4.5 million patients need blood transfusions in the United States and Canada.Someone needs blood on an average of every 2 seconds.The May 21, 2008, issue of JAMA includes an article about blood donations by 16-and 17-year-olds.This Patient Page is based on one published in the April 17, 2002, issue of JAMA.
SP0192 “A Professional Career with A Rheumatic Disease”. Obstacles and Possibilities in Germany in Combination with A Personal Perspective
Authors: G. Baseler
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Young people with a musculoskeletal disease all over the world have to cope with many different hindrances every day. School, education and starting a professional career – young people with arthritis are confronted with barriers in every aspect of life. Especially hindrances regarding a professional career are very difficult to overcome. <h3>Objectives</h3> Besides sharing my personal experience of managing an education, starting a professional career and living with a chronic disease, I will tell about other young rheumatics in Germany. Including obstacles in daily life, mental barriers will be revealed and a view into a complex system of different interests, helping hands and hindrances will be given. <h3>Methods</h3> In 2009 the Deutsche Rheuma-Liga conducted a survey among young rheumatics and their parents in order to gain a closer look at their health care situation, their education and working situation. In autumn 2014 a conference for young rheumatics and their parents was held and focused on the working situation and the labour law. <h3>Results</h3> The results of the survey (Versorgungssituation rheumakranker Kinder und … Junger Rheumatiker) of the Deutsche Rheuma-Liga have been collected and can be studied online. Equally the workshop of young rheumatics and their parents in 2014 has been documented and is accessible online. <h3>Conclusions</h3> Suffering from a chronic disease - like a musculoskeletal one – and starting a professional career needs helping hands in many different parts of daily life. But it is not an unsolvable problem. There are still a lot of deficits – in our minds as well as in our educational and work systems – but with patience and active demands to reduce these deficits, they can become challenges. <h3>References</h3> Survey: wwws://www.rheuma-liga.de/fileadmin/user_upload/Dokumente/Hilfe_bei_Rheuma/Krankheitsbilder/umfrageergebnisse_versorgung.pdf Workshop: wwws://geton.rheuma-liga.de/buko <h3>Disclosure of Interest</h3> None declared
AB1115 The Characteristics of Therapy of Patients with Rheumatoid Arthritis in the Russian Federation According to the Russian Register
Authors: D. Karateev, A. Satybaldyev, E. Luchikhina, G. Lukina, E. Nasonov, A. Artyomov, O. Mazurova
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Development of registers of patients is one of the most important directions in studying of rheumatoid arthritis (RA) which can provide unique information. Until recently there was no unified register of patients with RA, but only registers of patients on specific therapies (the largest – the Russian biologics register ARBITER). <h3>Objectives</h3> To obtain reliable information about the real-world clinical practice in the area of the management of patients with rheumatoid arthritis. <h3>Methods</h3> The project of All-Russian Register of patients with Rheumatoid Arthritis (ARRRA) started in March, 2012. Due to large number of regions (85) in Russian Federation, and long distances between them, the register was created as internet-based database. Patient population included: patients with RA according to classification criteria (ACR/EULAR 2010 and/or ACR 1987), patients with early RA (including probable RA), adult patients with juvenile arthritis. ARRA database contains the following core information: demographics, classification criteria, comorbidities, RF/ACPA status, joint counts, Indices of activity: DAS28, SDAI, CDAI, PROs: VAS, HAQ, RAPID3, EQ 5D, anti-rheumatic and concomitant medications, serious adverse events, non-pharmacological treatments, orthopedic surgery, employment status. <h3>Results</h3> 4685 patients included at Nov 2014 from 16 main rheumatology centers, representing 71 regions of Russia. 3670 patients had definite diagnosis of RA (after exclusion of juvenile arthritis and probable RA): 82,6% females, 17,4% males, 74,3% RF positive. Comorbid conditions were listed in 52% of pts, the main conditions were arterial hypertension (39,9%) and IHD (12,5%). At Nov 2014, 89,1% pts received synthetic DMARDs, including 76,1% on methotrexate (MTX), alone or in combination, these proportions was relatively stable since Dec 2012. The proportion of patients being on biological DMARDs increased from 11,4% in Dec 2012 to 21% in Nov 2014. The proportions of patients used oral steroids and NSAIDs decreased from 67,8% and 80,1% to 57,9% and 63,2% respectively. Mean DAS28 score changed during this period from 5.04±1,42 to 3,98±1,31. <h3>Conclusions</h3> The increased use of methotrexate and biologic DMARDs corresponds to the decrease of disease activity, oral steroids and NSAIDs use in wide population of patients with RA in Russian Federation. <h3>Disclosure of Interest</h3> None declared
PWE-352 Asymptomatic radiologically detected colonic perforations in the english NHS bowel cancer screening programme (NHSBCSP)
Authors: E Derbyshire, C Nickerson, A Hungin, MD Rutter
Journal: Gut (2015)

<h3>Introduction</h3> Colonoscopic perforation remains one of the most serious adverse events associated with colonoscopy. Patients typically present with symptoms as a result of peritoneal irritation, however, colonic perforation may be diagnosed radiologically in patients who are entirely asymptomatic. The aims of this study were to identify cases of asymptomatic radiologically detected colonic perforation in the English NHSBCSP, describe similarities between them and explore why such perforations occur. <h3>Method</h3> We identified all reported cases of colonoscopic perforation from the start of the NHSBCSP in 2006 up to and including 13/03/2014 from the web based database used by the NHSBCSP, the Bowel Cancer Screening System. The NHSBCSP definition of perforation is: air, luminal contents or instrumentation outside the gastrointestinal tract. Bowel Cancer Screening Centres were subsequently asked to complete an online questionnaire relating to the patient’s post perforation presentation, management and outcome. <h3>Results</h3> Of 147 perforations identified, complete data on 117 was received. Four asymptomatic radiologically detected colonic perforations were identified. Case 1 was a biopsied rectal cancer. Staging Magnetic Resonance Imaging (MRI) and staging Computed Tomography (CT) 12 and 14 days respectively following colonoscopy noted a sealed off perforation posterior to the rectum. Two cases were associated with a biopsied sigmoid cancer; one a perforation identified at staging CT 2 days following colonoscopy, the other on a same day completion CT virtual colonoscopy after the cancer was impassable endoscopically, showing gas to the right of the tumour. Case 4 was a biopsied hepatic flexure cancer with perforation diagnosed on staging CT 24 h later. TNM classification was reported in 3 cancers: T3N0M0, T4N1MO and T4N2M0. Histology confirmed well/moderately differentiated adenocarcinoma in 3 cancers. Two of these patients were recalled to hospital following CT findings, subsequently having surgery. The other 2 did not require immediate admission. <h3>Conclusion</h3> All asymptomatic radiologically detected perforations were associated with colorectal cancer seen on staging radiological investigation. It is likely that only perforations associated with cancer will present asymptomatically as it is only they that have staging radiological investigation. TNM classification was at least T3. Emergency surgery was not required in three of these patients. The underlying cause of this sub group of perforations is perhaps more likely to be due to invasion of the cancer and not biopsy of it, however, a larger case series is required to confirm these findings. <h3>Disclosure of interest</h3> None Declared.
Production of Ring-Shaped Particles by Normal and Metaplastic Tissue. I. Human Skin2
Authors: Donald E. Rounds, K. Shankar Narayan, Norman E. Levan
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Production of Ring-Shaped Particles by Normal and Metaplastic Tissue. I. Human Skin Get access Donald E. Rounds, Donald E. Rounds Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Shankar Narayan, K. Shankar Narayan Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman E. Levan Norman E. Levan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 1, July 1975, Pages 7–10, https://doi.org/10.1093/jnci/55.1.7 Published: 01 July 1975 Article history Received: 30 August 1974 Accepted: 05 March 1975 Published: 01 July 1975
Various Coagulation Techniques Tested in a Rabbit Model
Authors: H.-H. Riedel, G. Corts-Kleinwort, K. Semm
Journal: Endoscopy (1984)

CO2-pelviscopies or laparotomies were performed in 370 New Zealand white rabbits, and were followed by coagulation of the distal uterine horns with unipolar, bipolar, endo- or CO2-laser coagulation. After 1, 2, 4, 8 or 12 weeks laparotomy was carried out and, following macroscopic description, photo documentation and measurement of the destroyed region, the uterine horns were excised.
FRI0400 Resistive Index as Marker of Activity in Lupus Nephritis Patients: Analysis of 60 SLE Patients
Authors: F. Ceccarelli, C. Perricone, A. Gigante, B. Barbano, L. Massaro, F.R. Spinelli, C. Alessandri, R. Cianci, G. Valesini, F. Conti
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Lupus nephritis (LN) affects up to 60% of patients with systemic lupus erythematosus (SLE), either as the initial manifestation or during the disease course. Moreover, LN has a negative impact on survival of SLE patients. Accordingly, it is mandatory to identify specific and feasible markers able to guide clinicians towards the adequate therapeutic option in LN patients. Recently, a significant correlation between pathologic Resistive Index (RI) and class IV nephritis was identified, suggesting a role for RI as a severity marker. <h3>Objectives</h3> We aimed at evaluating the role of RI as a marker of activity in a large cohort of LN patients. <h3>Methods</h3> Consecutive patients with SLE who required a kidney biopsy were enrolled. SLE patients with known renal artery stenosis, heart failure, hepatic diseases and urinary tract obstruction were excluded. Functional renal evaluation was performed by assessing serum creatinine (mg/dL), blood urea nitrogen (BUN, mg/dL) and daily urinary protein excretion (g/24 h). Moreover, the estimated glomerular filtration rate (eGFR, mL/min) was assessed by using the formula developed by the Modification of Diet in Renal Disease Study. Immediately before renal biopsy, the ultrasonography evaluation was performed to assess RI (Aplio Ultrasound System SSA-790; convex probe 3.5-MHz, Toshiba, Tokyo, Japan). An RI value &gt;0.7 was considered pathologic. The histologic characteristics of each kidney biopsy were registered in accordance with the International Society of Nephrology/Renal Pathology (ISN/RPS) Classification. Finally, biopsy-based activity (range: 0–24) and chronicity (range: 0–12) indices were calculated. <h3>Results</h3> Sixty patients (M/F 4/56; mean age 35.3±11.3 years; mean disease duration 150.0±90.0 months) underwent kidney biopsy. According with ISN/RPS classification, 29 (48.3%) patients had a class IV, 17 (28.3%) a class III, 8 (13.4%) a class II, and 6 (10.0%) a class V LN. Seven patients (11.7%) showed an RI&gt;0.7: one had a class III and 6/7 (85.7%) had a class IV. The evaluation of the activity index demonstrated the presence of significant higher values in patients with an RI&gt;0.7 compared with those with normal RI values (8.6±5.0 versus 4.2±3.9; P=0.03). Moreover, RI values significantly correlated with age (P=0.01; R=0.3), creatinine levels (P=0.005; R=0.3), BUN (P=0.02; R=0.2), and eGFR (P=0.006; R=-0.3). <h3>Conclusions</h3> In the present study, a significant association between pathologic RI and histological activity index in LN patients was found. In addition, we identified an association between pathological RI and a more severe kidney involvement suggesting a role of RI as an activity and severity marker of LN. <h3>Disclosure of Interest</h3> None declared
Dexamethasone suppression tests in patients with panic disorder
Authors: J A Lieberman, R Brenner, M Lesser, E Coccaro, M Borenstein, J M Kane
Journal: American Journal of Psychiatry (1983)

Dexamethasone suppression tests were given to 10 patients with panic disorder and 22 depressed patients. All patients with panic disorder were normal suppressors, and nine depressed patients were nonsuppressors. The mean cortisol levels of the two groups differed significantly.
Five Gene Probes Carry Most Of The Discriminatory Power Of The 70-Gene Risk Model In Multiple Myeloma
Authors: Christoph Heuck, Pingping Qu, Frits van Rhee, Sarah Waheed, Saad Z Usmani, Joshua Epstein, Qing Zhang, Antje Hoering, John Crowley, Bart Barlogie
Journal: Blood (2013)
Comparing arrest rates of mental patients and criminal offenders
Authors: H J Steadman, D Vanderwyst, S Ribner
Journal: American Journal of Psychiatry (1978)

The authors compared the arrest rates of former mental patients with those of criminal offenders released in the same jurisdiction. The data for all ex-patients and all offenders released in Albany County, New York, in 1968 and 1975 support the contention that it is the relationship between prior and subsequent arrests that explains the increasing crime rate of ex-patients and the three to six times higher rate of arrest of released offenders. Since the three-quarters of former patients with no arrest records were arrested about as often as the general population and substantially less often than offenders, care is warranted in drawing inferences from overall mental patient arrest rates.