tbuckley/cabot-search huggingface dataset:
Abstract 2334: Anti-angiogenic activity of anthrax lethal toxin using the mouse retina as a model system
Authors: Jennifer L. Bromberg-White, Elissa Boguslawski, Nicholas S. Duesbery
Journal: Cancer Research (2012)

Abstract Our laboratory has previously shown that inhibition of MKK pathways by anthrax lethal toxin (LeTx) inhibits tumor growth and angiogenesis, reduces VEGF secretion, and results in rapid cessation of blood flow to tumors in melanoma and sarcoma xenograft model systems. To gain insight into the anti-angiogenic nature of LeTx, we utilized both developmental and pathological models of vascularization in the murine retina. By immunoblotting and immunofluorescence microscopy we observed that MAPK activation occurs in a spatially and temporally regulated manner during retinal vascular development. Intravitreal administration of LeTx caused an early delay in retinal vascular development followed by the formation of abnormal vascular tufts that co-stained with phosphorylated MAPK in the outer retinal region. Using a model of oxygen-induced retinopathy, western analysis revealed that MAPK activation preceded the onset of hypoxia and development of neovascularization in this model system. Intravitreal injection of LeTx during hypoxia resulted in a persistent lack of development and progression of all pathologic aspects of neovascularization, while having minimal effect on macrophage recruitment. VEGF levels remained at an elevated level even with the persistent lack of neovascular growth and continued hypoxic environment, implying a VEGF-independent mechanism for the effects of MKK inhibition. Additionally, immature retinal vasculature during normal development was persistently destroyed following MAPK inhibition, while mature vessels from adult animals were unaffected. Our studies not only reveal that MKK signaling plays a key role in retinal angiogenesis but also that perturbation of MKK signaling by LeTx can profoundly alter vascular morphogenesis. The persistent destruction of immature vessels during normal vascular development in the retina and in the model of oxygen-induced retinopathy suggests an extreme sensitivity of immature vessels to MKK signaling inhibition. Since MKK inhibition prevents oxygen-induced retinopathy by a mechanism independent of the VEGF-targeting strategies, this approach may be used in conjunction with existing strategies utilizing VEGF inhibitors to prevent pathologic angiogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2334. doi:1538-7445.AM2012-2334
Quantitative gene expression analysis using Oncotype DX in ductal carcinoma <i>in situ</i> that is adjacent to invasive ductal carcinoma.
Authors: FL Baehner, C Sangli, C Millward, D Cherbavaz, A Goddard, S Shak
Journal: Cancer Research (2009)

Abstract Abstract #2066 Background: It is common for ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) to be observed adjacent to each other in the same tissue section. To explore the quantitative biology of DCIS, we measured ER, PR, HER2, proliferation gene expression and Recurrence Score (RS) using Oncotype DX in DCIS adjacent to IDC.&amp;#x2028; Material and Methods: Thirty cases of ER positive tumors were identified with adjacent DCIS and IDC of similar nuclear grade. Manual microdissection was performed to separate DCIS and IDC tissues from each case. Using the Oncotype DX assay, standardized quantitative expression of 16 individual cancer related genes including ER, PR and HER2 and the proliferation index (the average of the 5 proliferations genes) was measured on a scale from 0 to 15 (relative to reference genes), where a one unit increment is associated with a 2-fold change in expression. The RS was also calculated. Descriptive statistics and Pearson's R correlation coefficients were determined to compare DCIS to IDC.&amp;#x2028; Results: 27 of the 30 samples had sufficient RNA for analyses of the DCIS component (8 with low grade, 10 with intermediate grade, and 9 with high grade DCIS). The correlation coefficients for the comparison of DCIS and adjacent IDC for quantitative ER, PR, HER2, and the proliferation index was 0.78, 0.73, 0.76, and 0.83, respectively. For ER, IDC and DCIS measures were within 2 units for all 27 cases and within 1 unit for 22/27 (81%). For PR, IDC and DCIS measures were within 2 units for 25 of 27 cases and within 1 unit for 19/27 (70%). For HER2, IDC and DCIS measures were within 2 units for 26 of 27 cases and within 1 unit for 24/27 (89%). For proliferation index, IDC and DCIS measures were within 2 units for all 27 cases and within 1 unit for 26/27 (96%). There was a wide range of RS in DCIS (mean 13.9; range 0 to 56). Although for RS there was a significant correlation between DCIS and IDC (R=0.84), on average the RS was 4 units lower for DCIS.&amp;#x2028; Discussion: Quantitative RT-PCR analysis of DCIS is technically feasible and sufficient RNA for Oncotype DX analysis is obtained in 90% of cases. As has been described previously for invasive breast cancer, there is considerable expression heterogeneity in DCIS between patients. DCIS adjacent to invasive breast cancer demonstrates very similar, but not identical, quantitative biology for the genes in the assay. Further DCIS studies to evaluate Oncotype DX and recurrence rates would be of great interest. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2066.
Cholecystoduodenal drainage and gallstone removal in a patient with cholecystitis and unresectable cholangiocarcinoma
Authors: B. Turner, S. Rotman, N. Paddu, D. Trost, A. Jamal-Kabani, M. Gaidhane, M. Kahaleh
Journal: Endoscopy (2013)

Cholecystitis is a complication that can develop in patients with malignant biliary strictures [1] [2]. We describe the endoscopic ultrasound (EUS)-guided placement of a novel metal stent to create a cholecystoduodenostomy in a nonoperable candidate with cholecystitis.
Continuous Hemofiltration in the Treatment of Acute Renal Failure
Authors: L.G. Forni, P.J. Hilton
Journal: New England Journal of Medicine (1997)

Acute renal failure that requires renal-replacement therapy is a relatively common condition, with an annual incidence of at least 30 cases per 1 million population.1 Historically, the replacement of renal function in acute renal failure has involved techniques also employed in the treatment of end-stage chronic renal failure — intermittent hemodialysis and peritoneal dialysis.2,3 Hemofiltration was first described in 1977 as a means of removing extracellular fluid from patients with edema refractory to diuretic agents.4 Continuous hemofiltration, combined with the administration of an appropriate fluid, is now recognized as a form of renal-replacement therapy in acute renal failure. The . . .
The Beat Goes On
Authors: Kathryn A. Britton, William G. Stevenson, Bruce D. Levy, Joel T. Katz, Joseph Loscalzo
Journal: New England Journal of Medicine (2010)

A 45-year-old man presented to the emergency room after a syncopal episode that occurred while he was watching a baseball game. The syncopal event was preceded by the sudden onset of lightheadedness. He awoke after several seconds, without confusion. He noted nausea and diaphoresis but reported no chest pain before or after the event.
ACS Keeps Mammography Guidelines for Women Under 50
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article ACS Keeps Mammography Guidelines for Women Under 50 Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 5, 3 March 1993, Pages 348–349, https://doi.org/10.1093/jnci/85.5.348 Published: 03 March 1993
AB1048 The Musculoskeletal Disorders as Cause of Sickness Absence in General Population in Poland
Authors: E. Stanislawska-Biernat
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Musculoskeletal disorders are common in the aging society but their burden is not widely recognized. Sickness absence related to musculoskeletal conditions is a public health problem with social and economic consequences. <h3>Objectives</h3> To demonstrate the prevalence of sickness absence related to musculoskeletal disorders and to provide the data for the measurement their burden in society. <h3>Methods</h3> Medically certified causes of sickness absence in Poland according to ICD-10 codes were analyzed. The data used in the study have been collected and recorded in 2012 for administrative purposes by main health and social insurer in Poland - The Social Insurance Institution (ZUS). The ranking of groups of diseases causing highest work absenteeism was performed. The numbers of sickness medical certificates, work days lost related to musculoskeletal disorders (M00-M99) were analyzed and compared to other causes of sickness absence. The ranking of rheumatic diseases causing the highest sickness absence was performed. <h3>Results</h3> The Social Insurance Institution registered 13 225 713 people as insured in 2012. All medically confirmed sickness absence certificates were reported and analyzed. Musculoskeletal conditions were the cause of 2 053 200 absence certificates (12,4% of all), the second cause (after the group of respiratory system diseases). Insured Poles lost 28 140 300 working days due to musculoskeletal disorders - 13,6% of total working days lost. For comparison the cardiovascular diseases caused 5,5% absence certificates and 6,1% days lost. In the ranking of ten conditions causing the highest work absenteeism there were four diseases related to back pain. In the group of musculoskeletal disorders (M00-M99) the back pain problems and osteoarthritis were the most prevalent causes of work absenteeism. Rheumatoid arthritis (M05, M06) was the reason of 35 249 sickness absence certificates and 560 330 working days lost. Possible modifiable factors influencing work absenteeism related to musculoskeletal disorders are discussed. Improvement of standards of care (early diagnostics, regular follow-up, access to modern treatment) may influence work absenteeism related to inflammatory diseases. Osteoarthritis and back pain being important social problem need the interdisciplinary approach, cooperation of scientists, health professionals, economists, patients organizations, media and policy makers. Social and economic consequences of sickness absence caused by common musculoskeletal conditions are presented and discussed. <h3>Conclusions</h3> Musculoskeletal disorders are prevalent and important cause of sickness absence. Their impact on society should be widely recognized. The health and social policy should be directed on factors, which can prevent work absenteeism and disability. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4491
Abstract 2103: XB05: a promising small molecule for cancer therapy.
Authors: Francesca R. Salipur, Elsa M. Reyes Reyes, Bo Xu, Ned Smith, Jian Cai, Gerald B. Hammond, Paula J. Bates
Journal: Cancer Research (2013)

Abstract XB05 is synthetic small molecule which was serendipitously discovered to have potent anticancer properties. XB05 displays selectivity for malignant cells over non-malignant cells. Human myeloid leukemia cells (U937) and human lung cancer cells (A549) treated with XB05 show an increase in oxidative stress, DNA damage and a mixed apoptotic and necrotic mechanism of cell death. We conducted a COMPARE analysis to search for correlations between XB05 response and gene expression using publicly available microarray studies of the National Cancer Institute 60 cell line panel. This analysis uncovered a correlation between cell death in response to XB05 and expression of the transcription factor, SOX9. We find that SOX9 is differentially expressed across a panel of human lung cancer cell lines. MTT proliferation and clonogenic cell survival assays suggest that SOX9 expression positively correlates with the sensitivity of lung cancer cells to XB05. Furthermore, we show that siRNA knockdown of SOX9 recapitulates the phenotype of XB05-induced cell death, and that SOX9 may be downregulated at the protein level by XB05 treatment. Overall, these data demonstrate potent activity of XB05 against human cancer cells via a novel mechanism of action, and a potential role for SOX9 as a biomarker for selection and monitoring of therapy with XB05. Citation Format: Francesca R. Salipur, Elsa M. Reyes Reyes, Bo Xu, Ned Smith, Jian Cai, Gerald B. Hammond, Paula J. Bates. XB05: a promising small molecule for cancer therapy. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2103. doi:10.1158/1538-7445.AM2013-2103
Abstract ADV24: Clinical Trials may be the safer treatment option with Personalized Medicine.
Authors: Jack Whelan
Journal: Cancer Research (2013)

Abstract The next generation of scientists and investigators that embrace the latest generation of Health IT, will play a pivotal role in developing solutions that deliver on the promise of Personalized Medicine. The poster presented shows Jack Whelan's six year journey and five clinical trials/treatment options for his rare, incurable blood cancer, his e-Patient observations about Clinical Trials and Personalized Medicine and recommended sources of patient advocate educational materials for these subject matters. Citation Format: Jack Whelan. Clinical Trials may be the safer treatment option with Personalized Medicine. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr ADV24. doi:10.1158/1538-7445.AM2013-ADV24
Abstract 3126: Intercellular communication in the urothelium: Evidence for a switch in gap junction regulation during differentiation
Authors: Jennifer S. Hinley, Lisa A. Kirkwood, Jennifer Southgate
Journal: Cancer Research (2011)

Abstract Cells have a requirement for intercellular communication in order to maintain normal tissue polarity and homeostasis. Knowledge of the signaling molecules transferred through specific gap junctions is limited; however aberrant expression of connexins, the protein subunits of gap junctions, has been linked to many disorders including neoplastic transformation of brain and colorectal tissues. A number of reports have documented changes in connexin expression associated with bladder cancer. The aims of this study were 1) to define the connexins expressed by the epithelial lining of the human urinary tract (urothelium) in situ and in vitro; 2) to determine if expressed connexins assemble into functional gap junctions and 3) the contribution of specific connexins to urothelial tissue physiology. Established culture systems for normal human urothelial (NHU) cells were used to replicate proliferative (regenerative) or differentiated cell phenotypes. RT-PCR was used to screen normal urothelial tissue and NHU cell cultures for expression of connexin genes. Immunochemical techniques were employed to determine connexin expression and localization in situ and in vitro. Dye-transfer techniques were used on cultured cells to confirm that assembled gap junctions supported functional cell-cell communication. Of the 20 human connexin genes, six were expressed in situ and by differentiated cultures, whilst two were expressed only in proliferative culture conditions. NHU cells were capable of dye transfer in both proliferative and differentiated cultures, indicating the presence of functional gap junctions. Immunofluorescence microscopy demonstrated that the switch in medium from a low (0.09mM) to near physiological (2mM) calcium concentration resulted in increased assembly of gap junctions containing connexin-43. Connexin-32 was only expressed by differentiated cultures, as shown by RT-PCR and immunochemistry, where it was localized to intercellular borders indicating a functional role. This data represents the first systematic characterization of connexin family expression in the urothelium and provides evidence that urothelial cells alter their connexin expression upon differentiation to produce specific channels. Connexin-32 has been reported to be involved in terminal differentiation of human mammary gland and future work will focus on characterizing the role of connexins in defining the differentiated urothelial phenotype. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3126. doi:10.1158/1538-7445.AM2011-3126
Detection of Synchronous Gastric Schwannoma on FDG PET/CT Aided by Discordant Metabolic Response
Authors: June Yap, Yi-Tung Tom Huang, Michael Lin
Journal: Clinical Nuclear Medicine (2015)

This is a case of an unsuspected synchronous gastric schwannoma demonstrating increased F-FDG accumulation on PET/CT in a 65-year-old female patient diagnosed with non-Hodgkin lymphoma on the basis of different metabolic activity to other sites of disease at staging and discordant metabolic response to therapy. The gastric schwannoma was confirmed by histopathology and immunohistochemistry after surgical resection. This case adds to the limited literature on FDG-avid gastric schwannoma and highlights the importance of investigating differential metabolic activity and response on serial PET/CT imaging.
Accuracy of Endoscopic Ultrasound for Vascular Invasion and Vascular Adhesion in Pancreatic Cancer: A single center experience
Authors: S Singh, J Talapaneni, S Puli, M Oropeza-vail, M Olyaee
Journal: Endoscopy (2006)

Introduction: Endoscopic Ultrasound (EUS) has emerged as an accurate tool to diagnose and stage pancreatic cancer. The reported accuracy of EUS to detect vascular adhesion or invasion in pancreatic cancer is variable. Aim: To asses the accuracy of EUS to diagnose vascular invasion and vascular adhesion in patients with pancreatic malignancy. Methods: Patients with pancreatic cancer who underwent EUS and surgery at one hospital were identified in a retrospective manner. EUS criteria for vascular adhesion was loss of echoplane alone. Vascular invasion was defined as tumor in the lumen or abnormal vessel contour or the presence of collateral vessels in the absence of a main vascular structure. Surgical definition for vascular adhesion was – tumor adherence but not precluding complete tumor resection and vascular invasion was defined as tumor encasing the vessel or vascular unresectability. Results: Total of 77 patients with pancreatic cancer and vascular involvement on EUS were identified. 41 out of 77 patients had surgery at our institution and were included in the analysis. EUS showed vascular invasion in 15 patients, vascular adhesion in 10 patients and no involvement in 16 patients. Superior mesenteric vessels were involved in 11 patients, portal vein in 12 patients, and splenic vein in 2 patients. The accuracy of EUS for vascular invasion and vascular adhesion is shown in table 1.
P416The correctiom of the ischemia-reperfusion brain injury by bioregulatory complex
Authors: N Maksimovich, I Dremza
Journal: Cardiovascular Research (2014)

The purpose was to study the dynamics of the change of the respiratory function of mythochondrias, in conditions of the brain ischemia-reperfusion (BIR) and introduction of bioregulatory complex (dihydroquercetin, 60 mg/kg, thiamine, 25 mg/kg, acetylcysteine, 100mg/kg, sodium succinate,100mg/kg). In studies respiratory functions of mythochondrias (V1 - velocity of endogenous respiration, V2 - velocity of substrate-dependent respiration, V3­ - velocity of the respiration afterc ADP introduction, V4 - respiratory velocity after loss of ADP, koefficient of acceptor control, V3/V2, koefficient of respiratory control (V3/V4), koefficient of phosphorilation (ADP/O) were studied. It was installed that introduction of of bioregulatory complex renders the corrective action on the respiratory functions of mythochondrias, caused by brain ischemia-reperfusion.
NUEVA INDICACIÓN CONSOLIDADA PARA LA CÁPSULA ENDOSCÓPICA DE INTESTINO DELGADO: ENFERMEDAD DE INJERTO CONTRA HUÉSPED (EICH)
Authors: A López Higueras, R Gómez Espín, E Fuentes, M López Espín, P Bebia, H Hallal, E Pérez Cuadrado
Journal: Endoscopy (2011)

Objetivos: La cápsula endoscópica (CE) es una técnica de primera línea en intestino delgado (ID). Su indicación en la enfermedad de injerto contra huésped (EICH), cuyo principal órgano diana es el ID, está en evaluación.
CEREBROSPINAL FLUID CHANGES IN ELECTROSHOCK TREATMENT OF PSYCHOSES
Authors: M. SPIEGEL-ADOLF, P. H. WILCOX, E. A. SPIEGEL
Journal: American Journal of Psychiatry (1948)

1. The cerebrospinal fluid of untreated schizophrenics shows a pronounced selective absorption in ultraviolet at λ= 2650 A. 2. Electroshock treatment influences the ultraviolet absorption of the cerebrospinal fluid (initial decrease, followed by increase on repeated application of high A. C.). 3. Enzymatic substances apparently belonging to the groups of nucleases and desaminases increase in the CSF following electroshock convulsions. 4. Lipases are much less affected by electroshock convulsions than are the nucleases.