tbuckley/cabot-search huggingface dataset:
Early Postoperative 18F-FDG PET/CT in High-Risk Stage III Colorectal Cancer
Authors: Nir Wasserberg, Ofer Purim, Vyacheslav Bard, Yulia Kundel, Noa Gordon, David Groshar, Natalia Goldberg, Hanoch Kashtan, Aaron Sulkes, Baruch Brenner
Journal: Clinical Nuclear Medicine (2015)

PET/CT may contribute to staging modification in different phases of colorectal cancer (CRC) management. However, it is not routinely indicated for stage III CRC. This study sought to determine the role of early postoperative PET/CT in patients with high-risk stage III CRC.The tumor registry of a tertiary medical center was searched (2004-2011) for all patients with stage III CRC who underwent early postoperative PET/CT because of the presence of high-risk factors for systemic disease. Demographic and clinicopathological characteristics were compared between patients found/not found to have metastatic disease.The cohort included 91 patients with a median age of 67 years (range, 29-90 years). Pathological FDG uptake was observed in 38 (41%). Of these, 14 (15% of the whole cohort) were upstaged with alteration of their treatment protocol, 10 (11%) had local postoperative changes, and 14 (15%) had false-positive findings. The sensitivity and specificity of PET/CT for detecting metastatic disease were 100% and 69%, respectively. Elevated postoperative carcinoembryonic antigen and CA-19.9 levels correlated with a positive PET/CT (P = 0.05 and P = 0.03, respectively). The median follow-up time was 34 months (range, 4-85 months). The estimated 5-year survival rate was significantly higher in patients with a negative than a positive scan (70% vs 42%, P < 0.0006).Findings on early postoperative PET/CT may influence staging and treatment in 15% of selected patients with high-risk stage III CRC. Postoperative levels of carcinoembryonic antigen and CA-19.9 may serve as indications for PET/CT scanning in this setting. Prospective validation is warranted.
SAT0499 Power Doppler Ulrasonographic Monitoring of Response to Treatment in Gout Patients
Authors: M. D. Peiteado Lopez, A. Villalba, E. De Miguel, E. Martin-Mola
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The accepted outcome measures for gout are seric urate, recurrent outbreaks, tophi regression and joint damage image. The Power Doppler ultrasound (PDUS) has demonstrated validity in the monitoring of treatment in other arthropathies, and it has been correlated with the presence of inflammatory activity. <h3>Objectives</h3> To evaluate the role of PDUS as a treatment monitoring tool in a cohort of gout patients. <h3>Methods</h3> In this 2 years longitudinal study, we prospectively evaluated patients with a clinical history suggestive of gout and at least one symptomatic flare in the last three months. Crystal identificaction by microscopy was made in all patients. Clinical and laboratory parameters were evaluated and treatment was adjusted to achieve an adequate disease control. In all visits (baseline, 6, 12 and 24 month) a second rheumatologist blinded to clinical data performed the ultrasound examination with a Logiq 9 equipment (General Electric Medical Systems, Milwaukee, WI, USA) with probe 9-14-MHz to scale grey and 5-7.5-MHz Doppler. Standardized examinations were carried out over four joints: first metatarsophalangeals (MTP) and knees (medial and lateral recesses); and the patellar tendons; and PD signal were scored. Mean and standard deviation was calculated for each parameter in the consecutive visits. The comparison between quantitative values ​​was performed by Student t test for paired samples. Sensitivity to change of the US was assessed by estimating the smallest detectable difference (SSD) in the Doppler total score. <h3>Results</h3> 24 consecutive patients (95.8% men) were included, with mean age of 60.8 (± 11 years), and mean disease duration of 10.3 years (IQR: 2-15). At baseline, 42, 71 and 50% were being treated with allopurinol, colchicine and NSAIDs, respectively. A significant decrease was observed in clinical and laboratory parameters, and also in the ultrasound Doppler signal (Table 1). The minimum detectable change at 2 years in Doppler score was 1.92, and it was lower than the difference between the baseline score and the score of the two years, which means that the detected change was independent of chance or measurement error. Despite an adequate disease control (62% of patients with serum urate &lt;6) the Doppler signal persists in a high percentage of patients (67%). <h3>Conclusions</h3> PDUS is sensitive to change in monitoring the treatment of gout. The 1<sup>st</sup>MTP joint is the more useful site for US treatment monitoring. The Doppler signal persists despite adequate control of the disease. <h3>Disclosure of Interest</h3> None Declared
Abstract 1565: API 31510 as a potential agent in management of CNS leukemia
Authors: Niven R. Narain, Lucia M. Mauro, Paula P. Perez, Caroline V. Caperton, Rangaprasad Sarangarajan, Joaquin J. Jimenez, John P. McCook
Journal: Cancer Research (2011)

Abstract Infiltration of cancer cells into the cerebrospinal milieu remains a challenge to oncologists. Thus, prophylactic therapy to avoid CNS tumors is now standard of care to avoid the development of tumors in the central nervous system (CNS). Despite the advances in oncological care, this issue remains poorly understood. In this regard, we have created a model of CNS chloroleukemia using Fischer 344 rats, in which chloroleukemic cells were injected when they are newborns and lipopolysaccharide (LPS) is given as a first-line of treatment. The cure rate with this regimen is 50%, and approximately 10% of survivors develop CNS leukemia as judged by their motor skills and the presence of quadriplegia and paraplegia. For this study, we injected 2400 Fischer 344 neonates with MIAC51 and treated them with LPS. All animals with overt signs of leukemia were sacrificed by day 26. By day 35, survivors started exhibiting CNS abnormalities. Of that cohort, we selected 150 animals with hind leg paraplegia on day 40. These animals were then re-randomized into 5 groups: group 1 received no treatment, group 2 received excipient control IV, group 3 received 5mg/kg API 31510 IV, group 4 received 25mg/kg IV, and group 5 received 100 mg/kg IV for 4 weeks, 3 times daily. Rats in groups 1, 2, 3 and 4 did not exhibit any signs of improvement and were sacrificed due to metastatic malignancy. These findings were recorded by MRI positive for tumor cells. In sharp contrast, animals injected with 100mg/kg IV exhibited a significant recovery of their motor skills and regained their ability to walk. MRI distinctly shows the lack of tumor cells in this group. Taken together, these results strongly indicate that API 31510 may provide a cure for CNS leukemia and may also be an effective prophylactic agent to prevent the extravasation of leukemic cells into the CNS. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1565. doi:10.1158/1538-7445.AM2011-1565
Gastric intramural hematoma caused by endoscopic ultrasound-guided fine-needle biopsy
Authors: Soichi Itaba, Toyoma Kaku, Yosuke Minoda, Hiroyuki Murao, Kazuhiko Nakamura
Journal: Endoscopy (2014)

A 75-year-old man was referred to our hospital for endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB). He had no remarkable medical history and was not receiving anticoagulant therapy. Laboratory testing revealed a normal platelet count and coagulation profile. A mass in the pancreatic tail had been noted on computed tomography at a previous hospital. Because autoimmune pancreatitis was suspected from the imaging studies, we used a 19-gauge needle (EchoTip ProCore; Cook Medical, Bloomington, Indiana, USA; [Fig. 1]) for EUS-FNB of the pancreatic tail mass, which was conducted via the gastric wall without suction. Sustained bleeding at the puncture site was observed after the first needle pass ([Fig. 2]). A dark blue bulge was also observed around the puncture site in the gastric wall. We diagnosed puncture site bleeding and gastric intramural hematoma. After endoscopic band ligation of the point of bleeding ([Fig. 3]), hemostasis was achieved, and enlargement of the intramural hematoma ceased. Computed tomography revealed gastric wall thickening and no hematoma in the retroperitoneal cavity. Esophagogastroduodenoscopy revealed fish scale-like mucosa around the band ligation site on the day after endoscopic band ligation ([Fig. 4]).
THU0166 Rebamipide in the treatment of xerostomia in sjægren’s syndrome: Randomized placebo-controlled study
Authors: A. Abou-Raya, S. Abou-Raya, N. Sallam, M. Helmii
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Xerostomia is a major distressing symptom in Sjögren's syndrome (SS). Persistent dryness of the mouth causes oral pain, discomfort and significantly interferes with the quality of life. Rebamipide, in addition to its gastro-protective effect has displayed various anti-inflammatory actions including inhibition of neutrophilic leukocyte activation. Preclinical and clinical studies have demonstrated an increase in saliva volume following rebamipide administration. <h3>Objectives</h3> To assess efficacy of rebamipide in the treatment of dry mouth symptoms related to Sjögren's syndrome. <h3>Methods</h3> Fifty-five patients (9 men, 46 women; of mean age 52.1 years) with American European Consensus Criteria Group (AECG)-based diagnosis of SS participated in this randomized double-blind placebo-controlled trial. Inclusion criteria included SS patients with dry mouth symptoms. Patients with dry mouth due to other conditions were excluded. Patients were randomized 1:1 to receive either 300mg/d (100mg ×3/day) of rebamipide or placebo for 12 weeks together with their usual therapy. Outcome measures included patient-assessed improvement of dry mouth symptoms and increase in salivary secretion (evaluation of unstimulated saliva; questionnaires including the visual analogue scale (VAS) for Sicca-syndrome VAS 0-100mm). Subjective and objective findings of dry mouth were recorded at baseline, two, four, six, eight, ten and twelve weeks. Safety and efficacy was assessed at each visit. <h3>Results</h3> A statistically significant improvement in dry mouth symptoms in the rebamipide-treated group compared to the placebo-treated group was observed. At two, four, eight, ten and twelve weeks, dry mouth improvement rates were respectively, 24.5, 46.3, and 49.9, 51.8 and 52.3% for rebamipide and 21.2, 25.1, 28,3, 29.0 and 33.6% for placebo.There was a statistically significant mean increase in salivary secreted volume at all time points in the rebamipide group compared to the control group. <h3>Conclusions</h3> The findings of the present study indicate that rebamipide had a salivary secretion increasing effect and improved symptoms of dry mouth. Rebamipide, may thus prove to be a useful adjunctive in the treatment of dry mouth symptoms in SS patients. Further large-scale longitudinal studies are however needed to clarify the efficacy of rebamipide. <h3>Disclosure of Interest</h3> None Declared
Bis(1H-2-indolyl)-1-methanones as inhibitors of the hematopoietic tyrosine kinase Flt3
Authors: S Teller, D Krämer, S-A Böhmer, KF Tse, D Small, S Mahboobi, C Wallrapp, T Beckers, K Kratz-Albers, J Schwäble, H Serve, F-D Böhmer
Journal: Leukemia (2002)
RATIO OF EARLY TRANSMITRAL VELOCITY TO MITRAL ANNULAR EARLY DIASTOLIC VELOCITY: COMPARISON OF THE PREDICTIVE VALUE OF SEPTAL AND LATERAL ANNULAR SITES IN 2,062 PERSONS FROM THE COMMUNITY
Authors: Joanna Wang, Tor Biering-Sorensen, Peter G. Jorgensen, Jan Jensen, Rasmus Mogelvang
Journal: Journal of the American College of Cardiology (2016)
Abstract 4360: Distinct energy metabolism in human pluripotent stem cells and differentiated cells regulated by UCP2
Authors: JIin Zhang, Ivan Khvorostov, Jason Hong, Yavuz Oktay, Laurent Vergnes, Esther Nuebel, Anna Do, Hea-Jin Jung, Michael McCaffery, Karen Reue, Carla Koehler, Michael Teitell
Journal: Cancer Research (2011)

Abstract It has been assumed, based largely on morphologic evidence, that human pluripotent stem cells (hPSCs) contain underdeveloped, bioenergetically inactive mitochondria. In contrast, differentiated cells harbor a fused, branching mitochondrial network, with oxidative phosphorylation (OXPHOS) as the main energy source. A role for mitochondria in hPSC bioenergetics therefore remains uncertain. Here we show that hPSCs have functional respiratory complexes that consume O2 at maximal capacity. Despite this, ATP generation in hPSCs is mainly by glycolysis. To help maintain hPSC mitochondrial membrane potential, cell proliferation, and viability, glycolytic ATP is hydrolyzed by the mitochondrial F1F0ATP synthase. Uncoupling protein 2 (UCP2) regulates this unique pattern of hPSC energy metabolism while suppressing reactive oxygen species. Upon differentiation, UCP2 is repressed and cells shift from glycolysis and fatty acid oxidation to glucose oxidation dependency. Ectopic UCP2 expression during differentiation blocks this metabolic transition and blocks proper embryoid body formation. Combined, our data show that hPSC have distinct bioenergetics regulated by UCP2 and repression of UCP2 is required for metabolic reprogramming along differentiation Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4360. doi:10.1158/1538-7445.AM2011-4360
Hypersensitivity Pneumonitis from <i>Pezizia domiciliana</i>
Authors: ROBERT S. WRIGHT, ZEB DYER, MYRON I. LIEBHABER, DONNA L. KELL, PHILIP HARBER
Journal: American Journal of Respiratory and Critical Care Medicine (1999)

A previously healthy woman developed severe dyspnea and was found to have restrictive lung disease and evidence of alveolitis. Open lung biopsy revealed extrinsic allergic alveolitis (hypersensitivity pneumonitis). The etiology was not initially apparent, but a home inspection showed an unusual mushroom growing in the patient's basement. Air sampling and serum precipitins against the fungal antigens confirmed that Pezizia domiciliana was the cause of the patient's hypersensitivity pneumonitis. This is the first described case of hypersensitivity pneumonitis cause by P. domiciliana. We speculate that unprecedented rainfall and flooding of the patient's basement as a result of El Niño rains produced ideal factors for the growth of this fungus. Wright RS, Dyer Z, Liebhaber MI, Kell DL, Harber P. Hypersensitivity pneumonitis from Pezizia domiciliana: a case of El Niño lung.
FRI0543 Pregnancy Outcome in Adult Juvenile Idiopathic Arthritis Patients Treated with Biologic Agents
Authors: K. Jarosova, K. Hejduk, M. Uher, J. Vencovsky
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> <b>Background:</b> Venous thromboembolism (VTE) is a significant complication following orthopedic intervention for neck of femur fracture. Our aim was to evaluate compliance with The National Institute for Health and Care Excellence guidance surrounding VTE prophylaxis before and after a brief intervention in an orthopedic department at a district general hospital. <b>Methods:</b> A 2-cycle quality improvement project was conducted. The primary outcome measure was whether adequate thromboprophylaxis was appropriately prescribed. For the intervention between the 2 cycles, posters were placed in key prescribing areas of all orthopedic wards. <b>Results:</b> In cycle 1, 63 (76.8%) patients were correctly prescribed enoxaparin, and 14 (17.1%) were prescribed other anticoagulants, leaving 5 patients (6.1%) who did not receive thromboprophylaxis for no apparent reason. In cycle 2, 56 (87.5%) patients were correctly prescribed enoxaparin, and the remaining patients were covered with alternative therapies. <b>Conclusion:</b> Small but basic interventions can lead to improvements in VTE prophylaxis prescribing. Future focus should be on implementing similar interventions across hospitals.
Cultural evolution in more than two dimensions: Distinguishing social learning biases and identifying payoff structures
Authors: Alex Mesoudi
Journal: Behavioral and Brain Sciences (2014)

Abstract Bentley et al.’s two-dimensional conceptual map is complementary to cultural evolution research that has sought to explain population-level cultural dynamics in terms of individual-level behavioral processes. Here, I qualify their scheme by arguing that different social learning biases should be treated distinctly, and that the transparency of decisions is sometimes conflated with the actual underlying payoff structure of those decisions.
Circulating Epithelial Tumor Cell (CETC) Monitoring during SERM and Aromatase Inhibitor Treatment for Early Detection of Patients Resistant to Tamoxifen.
Authors: K. Pachmann, O. Camara, C. Rabenstein, H. Winzer, I. Runnebaum
Journal: Cancer Research (2009)

Abstract The observation, that part of breast cancer patients benefit from ovarectomy led to the realization that in these patients the estrogen receptor crucially contributes to the growth potential of malignant tumors of the female reproductive system. This has led to the development of compounds specifically binding to the estrogen receptor but without activating activity. Although this has led to an impressive improvement in relapse free survival a considerable part of patients some of which being carriers of the CYP2D6 polymorphism will not respond to this targeted treatment. Therefore, in addition to defining the subpopulation with a high probability of responding to the targeted therapy only an immediate control of the response to treatment will ultimately improve outcome.Epithelial tumor cells circulating in peripheral blood are easily accessible and have been shown to reflect the response of the tumor to therapy. They can, therefore, be used to monitor the effect of therapy also in the adjuvant situation when the tumor has been removed by surgery.Here we report on the application of therapy monitoring using CETCs during adjuvant hormone blocking therapy. ER positive breast cancer were prospectively analysed for the number of CETC before therapy, before each new cycle of chemotherapy and during maintenance therapy with tamoxifen of aromatase inhibitor or during switch from one principle to the other. 1ml of blood was drawn into EDTA vials, red blood cells lysed and the white blood cell pellet stained with FITC-labelled anti-Epcam. Green fluorescent cells were detected by image analysis and dead cells excluded due to red PI fluorescence.178 patients were followed initially at quarterly intervals and later at annual intervals for their numbers of CETCs. 131 patients remained disease free during the observation interval of up to 7 years and 47 (26%) suffered distant relapse. Of the patients in complete continuous remission, 58% showed decreasing or stable CETCs whereas in the patients with relapses 73% showed increasing CETCs.45 patients were subsequently switched to aromatase inhibitor treatment, 17 relapsed patients and 28 patients without evidence of disease. Of the relapsed patients 35% have remained progress free all with a re-decrease in CETCs during AI treatment.Thus, gauging of CETCs can help to monitor hormone treatment and in the future contribute to early switch patients to AI if an increase in CETCs indicates resistance to tamoxifen. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5129.
Hépaticogastrostomie guidée sous échoendoscopie: étude rétrospective portant sur 44 patients consécutifs
Authors: E Bories, F Caillol, C Pesenti, M Giovannini
Journal: Endoscopy (2011)

Introduction: La possibilité de réaliser des drainages biliaires lors d'échoendoscopies thérapeutiques a rajouté une possibilité d'effectuer le drainage biliaire après échec de la voie rétrograde (CPRE). La réalisation d'hépaticogastrostomie guidée par échoendoscopie (EE-HG) par voie transgastrique aurait pour avantage de faciliter les gestes de reperméabilisation et améliorer la durée de perméabilité, le drainage étant réalisé en extratumoral. Cette étude rétrospctive a pour but d'analyser la faisabilité de cette technique ainsi que le suivi à long terme.
953 FUT2 POLYMORPHISM IS ASSOCIATED WITH DOMINANT STENOSIS AND CANDIDA INFECTION IN PRIMARY SCLEROSING CHOLANGITIS
Authors: C. Rupp, K. Friedrich, J.E.R. Hov, K.-H. Weiss, A. Wannhoff, A. Stiehl, P. Schemmer, P. Sauer, P. Schirmacher, H. Runz, T.H. Karlsen, W. Stremmel, D.N. Gotthardt
Journal: Journal of Hepatology (2013)
Abstract LB-391: HDAC6 is a dual enzyme with deacetylase and E3 ligase activities for MSH2 degradation
Authors: Mu Zhang
Journal: Cancer Research (2012)

Abstract MSH2 is a key DNA mismatch repair (MMR) protein that functions as an MSH2/MSH6 heterodimer (MutSa) in repairing errors after DNA replication as well as sensing certain types of DNA damage. It is believed that reduction of MutSα attenuates recognition of DNA adducts which renders a declined cell cycle arrest and apoptosis upon DNA damage and subsequently leads to chemotolerance. However, the mechanisms of down-regulation of MutSa are largely unknown. Here we show that histone deacetylase 6 (HDAC6) is co-purified with MutSa in HeLa nuclear extracts. Interestingly, we have found that HDAC6 itself serves as a ubiquitin E3 ligase to promote MSH2 polyubiquitination which renders MSH2 degradation by proteasome pathway. Intriguingly, HDAC6 prefers to target MSH2 monomer over MutSa for ubiquitination and degradation. Mechanistically, HDAC6 E3 ligase activity primarily resides in the N-terminal region encompassing the previously identified deacetylase domain 1 (DAC1) whereas its deacetylase activity resides in the deacetylase domain 2 (DAC2). We also showed that HDAC6 E3 ligase activity towards acetylated MSH2 is facilitated by its deacetylase activity in vivo. MSH2 lysine 249 and 892 can be either acetylated or ubiqutinated in vivo. These data suggest that HDAC6 sequentially deacetylates and ubiquitinates MSH2 via its DAC2 and DAC1 domains to target MSH2 degradation in vivo. Moreover, cells lacking or depleted of HDAC6 exhibit elevated levels of MSH2 due to impaired ubiquitin-proteasome-mediated degradation and subsequently prolonged half-life, compared with control cells. In agreement with this, HDAC6 knockout cells display higher MMR activity compared with wild type cells. Importantly, absence or reduction of HDAC6 leads to an increased cellular sensitivity to 6-TG and MNNG, whose DNA lesions were recognized by MutSa, suggesting that HDAC6 governs MSH2-dependent cytotoxicity induced by 6-TG or MNNG. Overall, our results identified a novel ubiquitin E3 ligase activity of HDAC6 and revealed that HDAC6 plays an important role in response to genotoxic stress. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-391. doi:1538-7445.AM2012-LB-391
EFFECTIVENESS OF THE AORTIC DISSECTION DETECTION RISK SCORE IN DIAGNOSING LOW-RISK PATIENTS
Authors: Anna Poteraj, Reed Pyeritz, Udo Sechtem, Himanshu Patel, Eva Kline-Rogers, Fabio Ramponi, Anthony DiScipio, Patroklos Pappas, Santi Trimarchi, Firas F. Mussa, Patrick O’Gara, Daniel Montgomery, Alan Braverman, Christoph A. Nienaber, Eric Isselbacher, Kim Eagle
Journal: Journal of the American College of Cardiology (2016)