tbuckley/cabot-search huggingface dataset:
Results of a Phase I Open-Label Study of Decitabine in Combination with Midostaurin (PKC412) for Elderly (Age ≥ 60) Newly Diagnosed or Relapsed/Refractory Adult Patients with Acute Myeloid Leukemia,
Authors: Casey B Williams, Suman Kambhampati, Siddhartha Ganguly, Omar S. Aljitawi, Ruben Reyes, Allan Fleming, Kapil N. Bhalla, Sunil Abhyankar, Joseph McGuirk
Journal: Blood (2011)
Comparison of different biopsy forceps models for tissue sampling in eosinophilic esophagitis
Authors: Christian Bussmann, Alain Schoepfer, Ekaterina Safroneeva, Nadine Haas, Sébastien Godat, Christine Sempoux, Hans-Uwe Simon, Alex Straumann
Journal: Endoscopy (2016)

<b>Background and aims:</b> Eosinophilic esophagitis (EoE) is a mixed inflammatory and fibrostenotic disease. Unlike superficial inflammatory changes, subepithelial fibrosis is not routinely sampled in esophageal biopsies. This study aimed to evaluate the efficacy and safety of deep esophageal sampling with four different types of biopsy forceps. <b>Patients and methods:</b> In this cross-sectional study, esophageal biopsies were taken in 30 adult patients by one expert endoscopist. Biopsies sampled from distal esophagus using a static jaw forceps (Olympus, FB-11K-1) were compared with proximal biopsies sampled with static jaw (Olympus, FB-45Q-1), alligator jaw (Olympus, FB-210K), and large-capacity forceps (Boston Scientific, Radial Jaw 4). One pathologist calculated the surface area of epithelial and subepithelial layers in hematoxylin and eosin (H&E)-stained biopsies. <b>Results:</b> Subepithelial tissue was acquired in 97 % (static jaw FB-11K-1), 93 % (static jaw FB-45Q-1), 80 % (alligator jaw), and 55 % (large-capacity) of samples. Median (interquartile [IQR]) ratios of surface area of epithelial to subepithelial tissue were: static jaw FB-45Q-1, 1.07 (0.65 – 4.465); static jaw FB-11K-1, 1.184 (0.608 – 2.545); alligator jaw, 2.353 (1.312 – 4.465); and large-capacity, 2.71 (1.611 – 4.858). The static jaw models obtained a larger surface area of subepithelial tissue compared with the alligator jaw (<i>P</i> < 0.001 and <i>P</i> = 0.037, for FB-11K-1 and FB-45Q-1, respectively) and the large-capacity forceps (<i>P</i> < 0.001, for both static jaw models). No esophageal perforations occurred. <b>Conclusions:</b> The static jaw forceps models allowed sampling of subepithelial tissue in > 90 % of biopsies and appear to be superior to alligator or large-capacity forceps in sampling larger amounts of subepithelial tissue.
A ComParison of Retroviral Integration Sites in Donor T-Lymphocytes In Vivo and In Vitro.
Authors: Frank A. Giordano, Stephanie Laufs, Boris Fehse, K. Zsuzsanna Nagy, Agnes Hotz-Wagenblatt, Daniel Lauterborn, Kurt Fellenberg, Klaus Kuehlcke, Sonja Naundorf, Axel R. Zander, W. Jens Zeller, Stefan Fruehauf
Journal: Blood (2005)
Naïve T Cell-Derived CTL Recognize Atypical Epitopes of CMVpp65 with Higher Avidity Than CMV-Seropositive Donor-Derived CTL – a Basis for Treatment of Post-Transplant Viral Infection by Adoptive Transfer of T Cells From Virus-naïve Donors
Authors: Patrick J Hanley, J. Joseph Melenhorst, Phillip Scheinberg, Gail J Demmler-Harrison, Daniele Lilleri, Giuseppe Gerna, Helen E. Heslop, Cliona M. Rooney, A. John Barrett, Elizabeth J Shpall, Catherine M. Bollard
Journal: Blood (2011)
A Crucial Cytotoxic Role of Anti-Idiotypic Antibody in Immunotherapy for B-Cell Neoplasms with Tumor Cell-Derived Heat Shock Protein 70.
Authors: Kazuya Sato, Junko Jimbo, Naoka Okamura, Takaaki Hosoki, Motohiro Shindo, Katsuya Ikuta, Yusuke Mizukami, Mikihiro Fujiya, Yoshihiro Torimoto, Yutaka Kohgo
Journal: Blood (2009)
DOMINO, doxycycline 40 mg vs. minocycline 100 mg in the treatment of rosacea: a randomized, single-blinded, noninferiority trial, comparing efficacy and safety
Authors: M.M.D. van der Linden, A.R. van Ratingen, D.C. van Rappard, S.A. Nieuwenburg, Ph.I. Spuls
Journal: British Journal of Dermatology (2017)

There is a lack of evidence for minocycline in the treatment of rosacea. To compare the efficacy and safety of doxycycline 40 mg vs. minocycline 100 mg in papulopustular rosacea. In this randomized, single‐centre, 1 : 1 allocation, assessor‐blinded, noninferiority trial, patients with mild‐to‐severe papulopustular rosacea were randomly allocated to either oral doxycycline 40 mg or minocycline 100 mg for a 16‐week period with 12 weeks of follow‐up. Our primary outcomes were the change in lesion count and change in patient's health‐related quality of life (using RosaQoL). Intention‐to‐treat and per protocol analyses were performed. Of the 80 patients randomized (40 minocycline, 40 doxycycline), 71 were treated for 16 weeks. Sixty‐eight patients completed the study. At week 16, the median change in lesion count was comparable in both groups: doxycycline vs. minocycline, respectively 13 vs. 14 fewer lesions. The RosaQoL scores were decreased for both doxycycline and minocycline, respectively by 0·62 and 0·86. Secondary outcomes were comparable except for Investigator's Global Assessment success, which was seen significantly more often in the minocycline group than in the doxycycline group (60% vs. 18%, P <0·001). At week 28, outcomes were comparable, except for RosaQoL scores and PaGA, which were significantly different in favour of minocycline (P = 0·005 and P = 0·043, respectively), and fewer relapses were recorded in the minocycline group than in the doxycycline group (7% and 48%, respectively; P <0·001). No serious adverse reactions were reported. Minocycline 100 mg is noninferior to doxycycline 40 mg in efficacy over a 16‐ week treatment period. At follow‐up, RosaQoL and PaGA were statistically significantly more improved in the minocycline group than in the doxycycline group, and minocycline 100 mg gives longer remission. In this study there was no significant difference in safety between these treatments; however, based on previous literature minocycline has a lower risk‐to‐benefit ratio than doxycycline. Minocycline 100 mg may be a good alternative treatment for those patients who, for any reason, are unable or unwilling to take doxycycline 40 mg.
Recombinant Human HPA-1A Antibodies for Treatment of Fetomaternal Alloimmune Thrombocytopenia (FMAIT): Proof of Principle in An in Vivo Murine Model and Human Volunteer Studies
Authors: Cedric Ghevaert, David A. Wilcox, Juan Fang, Kathryn Armour, Mike R Clark, Willem H. Ouwehand, Lorna M Williamson
Journal: Blood (2008)
Patient-Specific Induced Pluripotent Stem Cells Recapitulate the Maturation Defect of Myelodysplastic Syndromes
Authors: Kazuhisa Chonabayashi, Masahiro Kawahara, Keisuke Okita, Masatoshi Nishizawa, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Shinya Yamanaka, Yoshinori Yoshida
Journal: Blood (2014)
NTCT-06HIPPOCAMPAL PROTON MR SPECTROSCOPY IN THE ASSESSMENT OF RADIATION INJURY AND THE CORRELATION TO NEUROCOGNITIVE FUNCTION IMPAIRMENT
Authors: Radim Jancalek, Petr Pospisil, Tomas Kazda, Martin Bulik, Marie Dobiaskova
Journal: Neuro-Oncology (2015)

BACKGROUND: The hippocampus is considered as the main radiosensitive brain structure responsible for postradiotherapy cognitive decline. We prospectively assessed correlation between memory change and hippocampal N-acetylaspartate (h-tNAA) concentration, a neuronal density and viability marker, measured by 1H-MR spectroscopy (MRS). METHODS: Patients with brain metastases underwent pre-radiotherapy (WBRT, 10x3.0Gy) MRS focused on the h-tNAA concentration and memory testing by Auditory Verbal Learning Test (AVLT) and Brief Visuospatial Memory Test-Revised (BVMT-R) was performed. The both procedures were repeated four months after WBRT and the h-tNAA and memory changes were correlated. RESULTS: Of the 20 patients, ten passed whole protocol. The h-tNAA concentration significantly decreased from pre-WBRT 8.9, 8.86 and 8.88 [mM] in the right, left and both hippocampi to 7.16, 7.65 and 7.4, respectively. In the memory tests a significant decrease was observed in AVLT_total-recall, BVMT-R_total-recall and BVMT-R_delayed-recall. The trend toward correlation was between the decreases in the left h-tNAA and BVMT-R_delayed-recall (p = 0.096) and between the right h-tNAA and AVLT_total-recall (p = 0.0885). CONCLUSIONS: A significant post-WBRT decrease in h-tNAA was proven by MRS as a feasible method for the in vivo investigation of radiation injury. Continuing recruitment focusing on other cognitive tests and metabolites is needed. Supported by grants IGA NT/14600, NT/14120 of the Czech Ministry of Health.
Unusual Sites of Malignancy
Authors: Suleiman Massarweh, Hari Dhingra
Journal: Journal of Clinical Oncology (2001)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.5.1574 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11230502 Unusual Sites of Malignancy Case 3. Solitary Splenic Metastasis in Lung Cancer With Spontaneous Rupture Suleiman MassarwehxSuleiman MassarwehSearch for articles by this author , Hari DhingraxHari DhingraSearch for articles by this author Show More Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX, Copyright © 2001 American Society of Clinical Oncology https://doi.org/10.1200/JCO.2001.19.5.1574 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
A New Predictive and Prognostic Marker for De Novo AML: Peripheral Blood CD34 (pCD34) Count at Recovery Following Remission Induction (RI) Therapy (Supp. by Ankara University-2003-0809114).
Authors: Mutlu Arat, Pervin Topcuoglu, Meltem K. Yuksel, Klara Dalva, Gulhis Gultekin, Gunhan Gurman, Onder Arslan, Muhit Ozcan, Meral Beksac, Nahide Konuk, Akin Uysal, Haluk Koc, Osman Ilhan
Journal: Blood (2005)
EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells
Authors: Shoumei Bai, Patrick Ingram, Yu-Chih Chen, Ning Deng, Alex Pearson, Yashar S. Niknafs, Patrick O'Hayer, Yun Wang, Zhong-Yin Zhang, Elisa Boscolo, Joyce Bischoff, Euisik Yoon, Ronald J. Buckanovich
Journal: Cancer Research (2016)

Little is known about the factors that regulate the asymmetric division of cancer stem-like cells (CSC). Here, we demonstrate that EGFL6, a stem cell regulatory factor expressed in ovarian tumor cells and vasculature, regulates ALDH+ ovarian CSC. EGFL6 signaled at least in part via the oncoprotein SHP2 with concomitant activation of ERK. EGFL6 signaling promoted the migration and asymmetric division of ALDH+ ovarian CSC. As such, EGFL6 increased not only tumor growth but also metastasis. Silencing of EGFL6 or SHP2 limited numbers of ALDH+ cells and reduced tumor growth, supporting a critical role for EGFL6/SHP2 in ALDH+ cell maintenance. Notably, systemic administration of an EGFL6-neutralizing antibody we generated restricted tumor growth and metastasis, specifically blocking ovarian cancer cell recruitment to the ovary. Together, our results offer a preclinical proof of concept for EGFL6 as a novel therapeutic target for the treatment of ovarian cancer. Cancer Res; 76(21); 6396-409. ©2016 AACR.
Acquired Somatic Uniparental Disomy is a Chromosomal Defect Important in Predicting Treatment Responses and Survival Outcomes in MDS, MDS/MPN and Secondary AML.
Authors: Ramon V. Tiu, Christine O'Keefe, Lukasz P. Gondek, Azim M. Mohamedali, Bartlomiej P. Przychodzen, Ghulam J. Mufti, Mikkael A. Sekeres, Anjali S. Advani, Michael A. McDevitt, Jaroslaw P. Maciejewski
Journal: Blood (2009)
The Effect of Aquaporin 2 Gene Variations on Plasma Levels of von Willebrand Factor and Factor VIII and on the Risk of Venous Thrombosis.
Authors: Anne Yael Nossent, Johanne H. Ellenbroek, Marijke Frolich, Frits R. Rosendaal, Rogier M. Bertina, Nine V.A.M. Knoers, Jeroen C.J. Eikenboom
Journal: Blood (2007)
Constitutive Activation of STAT1 and STAT3 Proteins on Serine and Tyrosine Residues Were Found in Majority of CLL Patients.
Authors: Jitka Chumchalova, Dana Klimesova, Viera Kuhrova, Hana Francova, Yvona Brychtova, Michael Doubek, Dana Dvorakova, Jiri Mayer
Journal: Blood (2006)
Magnetic Resonance T2* Technique for Segmental and Global Quantification of Myocardial Iron : Multi-Centre Validation in the MIOT (Myocardial Iron Overload in Thalassemia) Network
Authors: Vincenzo Positano, Anna Ramazzotti, Alessia Pepe, Cristina Salvatori, Paolo Marcheschi, Antonella Meloni, Maurizio Mangione, Maria Filomena Santarelli, Paolo Cianciulli, Vincenzo Caruso, Aurelio Maggio, Luigi Landini, Massimo Lombardi
Journal: Blood (2008)
P0658 : A new prognostic model for 1-year mortality in patients with decompensated hepatitis B virus-related liver cirrhosis receiving antiviral treatment
Authors: T.H. Kim, S.H. Um, D.H. Gu, S.B. Yoon, T.J. Yun, S.Y. Yim, J.Y. Jung, Y.S. Seo, H.J. Yim, B. Keum, Y.T. Jeen, H.S. Lee, H.J. Chun, C.D. Kim, H.S. Ryu
Journal: Journal of Hepatology (2015)
Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes
Authors: Siddhartha Jaiswal, Pierre Fontanillas, Jason Flannick, Alisa Manning, Peter Grauman, Brenton G. Mar, R. Coleman Lindsley, Craig Mermel, Noel Burtt, Alejandro Chavez, John M. Higgins, Vladislav Moltchanov, Leena Kinnunen, Heikki Koistinen, Claes Ladenvall, Gad Getz, Adolfo Correa, Stacey Gabriel, Sekar Kathiresan, Heather Stringham, Jaako Tuomilehto, Christopher A. Haiman, Leif Groop, Gil Atzmon, James Wilson, Donna S. Neuberg, David Altshuler, Benjamin L Ebert
Journal: Blood (2014)
Usage of IGHV4-39 with Stereotypic B Cell Receptor Is An Independent Risk Factor of Chronic Lymphocytic Leukemia Transformation to Richter Syndrome
Authors: Davide Rossi, Valeria Spina, Michaela Cerri, Clara Deambrogi, Lorenzo De Paoli, Luca Laurenti, Rossana Maffei, Francesco Forconi, Vincenzo Canzonieri, Francesco Bertoni, Maurizio Martini, Silvia Rasi, Michele Magni, Silvia Deaglio, Marco Ladetto, Antonello Cabras, Josep Nomdedeu, Caroline Besson, Roberto Marasca, Luigi Larocca, Valter Gattei, Gianluca Gaidano
Journal: Blood (2008)
Superior Canal Dehiscence
Authors: John Pidgeon
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishment of Blood Outgrowth Endothelial Cells from a Type 3 Von Willebrand Disease (VWD) Patient with a Neutralizing Anti-VWF Inhibitors
Authors: Naomi Sanda, Nobuaki Suzuki, Mayuko Kishimoto, Natsumi Kameyama, Yoko Kajiura, Hiroyuki Matsumoto, Shigeo Nakamura, Tadashi Matsushita
Journal: Blood (2014)
Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal
Authors: Chandni V. Jain, Leena Kadam, Marie van Dijk, Hamid-Reza Kohan-Ghadr, Brian A. Kilburn, Craig Hartman, Vicki Mazzorana, Allerdien Visser, Michael Hertz, Alan D. Bolnick, Rani Fritz, D. Randall Armant, Sascha Drewlo
Journal: Science Translational Medicine (2016)

Fetal trophoblast cells obtained noninvasively early in gestation provided fetal DNA for comprehensive targeted sequencing across the genome.
Tremelimumab in combination with ablation in patients with advanced hepatocellular carcinoma
Authors: Austin G. Duffy, Susanna V. Ulahannan, Oxana Makorova-Rusher, Osama Rahma, Heiner Wedemeyer, Drew Pratt, Jeremy L. Davis, Marybeth S. Hughes, Theo Heller, Mei ElGindi, Ashish Uppala, Firouzeh Korangy, David E. Kleiner, William D. Figg, David Venzon, Seth M. Steinberg, Aradhana M. Venkatesan, Venkatesh Krishnasamy, Nadine Abi-Jaoudeh, Elliot Levy, Brad J. Wood, Tim F. Greten
Journal: Journal of Hepatology (2016)
TKI Treatment Discontinuation: How Many Patients Could Stop Tyrosine Kinase Treatment According to Discontinuation Trials Criteria? Incidence and Prognostic Impact of Deep Molecular Response in a Cohort of Chronic Myeloid Leukemia Patients of South Brazil's Hematology Centers
Authors: Laura Fogliatto, Marcelo Eduardo Zanella Capra, Mariza Shaan, Tito Vanelli Costa, Luis Carlos Zanandrea Contin, Raquel Breunig, Juarez Fontoura Silveira, Mayde Seadi Torriani, Katia Fassina, Mario Sergio Fernandes, Denise Almeida, Marco Antonio Schilling, Tânia Hellwig, Tiago Daltoe, Mariangela Moschen, Adriana Zardo, Moema Nene, Liane Esteves Daudt, João Friedrisch, Lucia Silla
Journal: Blood (2014)
99mTc-DMSA Uptake in a Sister Mary Joseph’s Nodule From Ovarian Cancer
Authors: Sleiman Naddaf, Fahad Azzumeea, Mohammed Fahad Alzayed
Journal: Clinical Nuclear Medicine (2016)

A 50-year-old woman with ovarian cancer underwent Tc-DMSA scan to evaluate the functional status of the right hydronephrotic kidney. The images incidentally revealed a well-defined focus of mild radiotracer uptake at the midanterior abdominal wall, which correlated with a metastatic Sister Mary Joseph's nodule seen on CT performed a week earlier.
Molecular Diversity Detected by Whole Exome Sequencing in Chronic Myelomonocytic Leukemia
Authors: Basel Rouphail, Kenichi Yoshida, Holleh D Husseinzadeh, Edward P Evans, Satoru Miyano, Yasunobu Nagata, Yuichi Shiraishi, Kenichi Chiba, Masashi Sanada, Bartlomiej P Przychodzen, Ines Gomez-Segui, Kathryn M Guinta, Manuel G. Afable, Yogen Saunthararajah, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Seishi Ogawa, Hideki Makishima
Journal: Blood (2012)
Sirolimus-Associated Rapid Progression of Leg Ulcers in a Renal Transplant Recipient
Authors: Mariam B. Totonchy, Oscar R. Colegio, Sean R. Christensen
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Association between vascular inflammation and non-alcoholic fatty liver disease: Analysis by 18F-fluorodeoxyglucose positron emission tomography
Authors: Hyun Jung Lee, Chang Hee Lee, Sungeun Kim, Soon Young Hwang, Ho Cheol Hong, Hae Yoon Choi, Hye Soo Chung, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei Hyun Baik, Dong Seop Choi, Kyung Mook Choi
Journal: Metabolism (2016)
Radioimmunotherapy In Relapsed/Refractory Mantle Cell Lymphoma Patients: Final Results Of a European MCL Network Phase II Trial
Authors: Simone Ferrero, Alessandro Pastore, Roswitha Forstpointner, Christian W. Scholz, Antonio Pezzutto, Lothar Bergmann, Lorenz Truemper, Juergen Finke, Ulrich Keller, Marco Ladetto, Wolfgang Hiddemann, Oliver Weigert, Michael Unterhalt, Martin Dreyling
Journal: Blood (2013)
Impact of High Risk Prognostic Parameters and Addition of Ibrutinib to Bendamustine/Rituximab (BR) on Outcomes for Patients with Relapsed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) from the Phase 3 Double-Blind HELIOS Trial
Authors: Asher Chanan-Khan, Paula Cramer, Graeme Fraser, Rodrigo Santucci Silva, Sebastian Grosicki, Aleksander Pristupa, Marie Sarah Dilhuydy, Andre Goy, Anthony R. Mato, Rajendra Damle, Charles Phelps, Michelle Mahler, Mariya Salman, Michael Schaffer, Angela Howes, Sriram Balasubramanian
Journal: Blood (2015)
CC-122 Exhibits Potent Anti-Lymphoma Activity in Combination with Obinutuzumab through Cell Autonomous and Antibody Dependent Cell Mediated Cytotoxicity
Authors: Hsiling Chiu, Patrick Hagner, Michael Pourdehnad, Thomas Daniel, Rajesh Chopra, Anke Klippel, Christian Klein, Anjan Thakurta, Anita K. Gandhi
Journal: Blood (2015)
Safety and Efficacy of a Volumizing Hyaluronic Acid Filler for Treatment of HIV-Associated Facial Lipoatrophy
Authors: Derek Ho, Jared Jagdeo
Journal: JAMA Dermatology (2016)

Facial lipoatrophy (FLA) is associated with human immunodeficiency virus (HIV) disease and the use of highly active antiretroviral therapy. The condition is primarily characterized by facial volume loss that affects the contours of the cheeks, temples, and orbits and may negatively affect patients' adherence to highly active antiretroviral therapy, psychological health, and quality of life. A single treatment of hyaluronic acid (HA) filler, 20 mg/mL, may provide an immediate, natural-appearing facial enhancement outcome.To evaluate the safety and efficacy of an HA filler for treatment of HIV-associated FLA during a 12-month follow-up.Open-label, safety and efficacy study in patients with HIV-associated FLA, a Carruthers Lipoatrophy Severity Scale (CLSS) grade of 2 or greater (range, 1-4, with higher scores indicating greater severity), and no previous treatment for FLA during the past year received 1 treatment and an optional touch-up. Twenty patients were treated and followed up at the Sacramento Veterans Affairs Medical Center, Mather, California, from March 5, 2015, to May 17, 2016.Midface (cheeks and temples) volumization was performed using the "smile-and-fill," fanning, and depot technique with an optional touch-up at the 2-week follow-up.Patients underwent evaluation at the initial visit and follow-up at 2 weeks and 3, 6, 9, and 12 months. Main outcome measures included safety (rate of treatment-related adverse events), CLSS grade, and Global Aesthetic Improvement Scale rating (5-point scale, ranging from worse to very much improved).Nineteen of the 20 patients (all men; mean [SD] age, 57 [10] years) completed all study visits. Baseline HIV-associated FLA severity was CLSS grade 2 in 16 patients; grade 3, in 3 patients; and grade 4, in 1 patient. The total mean (SD) volume of HA used was 6.1 (3.1) mL for grade 2 FLA; 9.3 (4.2) mL for grade 3 FLA; and 26.0 (0) mL for grade 4 FLA (1 mL equals 1 syringe of HA filler). All 19 patients maintained a significant improvement of CLSS (grade 1) and Global Aesthetic Improvement Scale rating (very much improved) with no treatment-related adverse events at 12 months.This study reports excellent safety and efficacy and supports use of this HA filler for treatment of HIV-associated FLA with durable results at 12 months. Future multicenter, randomized clinical trials with blinded independent investigators are needed to demonstrate the long-term safety, efficacy, and durability of this HA filler for treatment of HIV-associated FLA.