tbuckley/cabot-search huggingface dataset:
THU0445 The Change of Laboratory Markers in Serum Under the Influence of Inhibitor of Interleukin-1 in the Therapy of Secondary Osteoarthritis in Patients with Rheumatoid Arthritis
Authors: I. Starodubtseva, L. Vasilieva, A. Nikitin, N. Barsukova
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Diacerein and its active metabolite, rhein, are anthraquinone derivatives. It is considered, that diacerein works by blocking/reducing the actions of interleukin-1β, a protein involved in the process of articular cartilage destruction and synovial inflammation <sup>1-4</sup>. <h3>Objectives</h3> To evaluate the dynamic of COMP, IL-1 in serum and activity on DAS 28 in patients with secondary osteoarthritis in rheumatoid arthritis treated with inhibitor of interleukin-1 and basis therapy. <h3>Methods</h3> We studied 124 patients with secondary osteoarthritis of the knee in rheumatoid arthritis (according to criteria EULAR/ACR) with the mean age of 44.02±9.52 years, the IInd stage of activity on DAS28, and the mean duration of the disease 6.3±4.2 years. Patients were divided into two groups and treated with 10-20 mg of methotrexate each week. Patients of group 1 (n=62) received diacerein 50 mg twice a day on the basis therapy. After the six-month treatment we estimated the dynamic of the level of serum COMP (ELISA), IL-1 (BMS 224/2) and DAS28 across the comparison groups. The model surfaces used for the analysis enabled us to obtain the integral estimation of the indicators9 dynamics. <h3>Results</h3> The constructed model surfaces indicated the decreased levels of IL-1, COMP and DAS28 in group I till 6,68±0,37 pg/ml (p&lt;0,001); 16,92±0,8 ng/ml ×10<sup>2</sup> (p&lt;0,001) and 2,06±1,19 (p&lt;0,05) respectively. Also the model surfaces revealed the interdependency of all these indicators. The second group reacted to the treatment by decreasing the indicators as well. However, the dynamics of the changes was significantly less. In comparison analysis we noted significant statistical advantages (p&lt;0,01) of the use of diacerein with methotrexate regarding the dynamic of IL-1 and COMP in patients9 serum. <h3>Conclusions</h3> The combination of inhibitor of interleukin-1 with methotrexate was more effective in subjects with decreasing levels of IL-1 and COMP in the serum of patients with secondary osteoarthritis in rheumatoid arthritis <h3>References</h3> Yaron M, et al. Anti-interleukin-1 effects of Diacerhein and Rheun in human osteoarthritis synovial tissue and cartilage cultures. Osteoarthritis Cartilage 1999;7(3):272-280. Alvarez-Soria MA, et al. Diacerein has a weak effect on the catabolic pathway of human osteoarthritis synovial fibroblast - comparison to its effects on osteoarthritic chondrocytes. Rheumatology (Oxford) 2008;47(5):627-33. Legendre F, et al. Rhein, the metabolite of diacerhein, reduces the proliferation of osteoarthritic chondrocytes and synoviocytes without inducing apoptosis. Scand J Rheumatol 2009;38(2):104-11. Assessment report for diacerein containing medicinal products. 28 August 2014 European Medical Agency/527347/2014. <h3>Disclosure of Interest</h3> None declared
PTU-325 Developing a pelvic radiation disease service – which patients do we see in a regional secondary care centre?: Abstract PTU-325 Table 1
Authors: R Stacey, B Cox, J Turner, J Green
Journal: Gut (2015)

<h3>Introduction</h3> Pelvic radiation disease (PRD) is a common yet under recognised condition causing significant gastrointestinal symtptoms in patients who have recieved radiotherapy for pelvic malignancy. Most studies to date have involved large, sub specialist centres, but the situation in other regions of the UK is unclear. Recent studies have advocated an algorithm based approach to managing these patients.<sup>1</sup>We have set up a PRD service as part of our general gastroenterology clinic and direct access endoscopy services. We performed a service evaluation to identify the trends of patients presenting to our service, and the investigations that we were performing. <h3>Method</h3> Using a database search and retrospective notes analysis, we identified patients seen by the gastroenterology service between 2005 and 2014 with PRD. We noted their initial cancer diagnosis, symptoms and investigation results. <h3>Results</h3> 108 patients were identified (57 female, 51 male). Overall median age was 70 years, however women were younger (median age 67 years) than men (76 years). The majority of male patients had urological malignancy (84%), in contrast to gynaecological (64%) in the female group. All males with urological malignancies were treated for prostate cancer. Rectal bleeding (43%) and diarrhoea (42%) were the most common symptoms recorded. Other symptom frequencies are outlined in Table 1. 88% of patients (n = 84) had more than one symptom at presentation. For patients experiencing rectal bleeding, endoscopy revealed angioectasia and radiation proctopathy in 49%, whereas Bile acid diarrhoea was the most common diagnosis made in the diarrhoea group, with 40% of SeHCAT scans being abnormal. Other diagnositic yields of performed tests included positive results in 20% of glucose hydrogen breath tests, 33% of lactose breath tests and 36% of positive fructose breath tests respectively. <h3>Conclusion</h3> Patients with PRD present with a variety of multiple symptoms following radiotherapy for pelvic malignancy. Service development to cater for this group must include adequate access to investigations and endoscopy. Although patients often require large numbers of investigations, the diagnostic yields are high. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Andreyev HJN, Benton BE, Lalji A, <i>et al</i>. Algorithm-based management of patients with gastrointestinal symptoms in patients after pelvic radiation treatment (ORBIT): a randomised controlled trial. Lancet 2013;382(9910):2084–2092
Follicular B Lymphomas Generate Regulatory T Cells via the ICOS/ICOSL Pathway and Are Susceptible to Treatment by Anti-ICOS/ICOSL Therapy
Authors: Kieu-Suong Le, Marie-Laure Thibult, Sylvain Just-Landi, Sonia Pastor, Françoise Gondois-Rey, Samuel Granjeaud, Florence Broussais, Reda Bouabdallah, Renaud Colisson, Christophe Caux, Christine Ménétrier-Caux, Dominique Leroux, Luc Xerri, Daniel Olive
Journal: Cancer Research (2016)

The prognosis of follicular lymphoma (FL) patients is suspected to be influenced by tumor-infiltrating regulatory T cells (Treg). The mechanism of Treg enrichment in FL and their impact on malignant FL B cells remains to be elucidated. We analyzed 46 fresh lymph node biopsy samples, including FL (n = 20), diffuse large B-cell lymphoma (n = 10), classical Hodgkin lymphoma (n = 9), and reactive lymphadenitis (n = 7). Using multicolor flow cytometry and cell sorting, we observed an accumulation of CD25(high)CD127(low/neg) Tregs in FL tissues. These Tregs comprised activated ICOS(+) Tregs that were able to suppress not only conventional T cells, but also FL B cells. These FL B cells were able to express ICOSL in vitro and to generate CD25(high)FoxP3(high) Tregs expressing ICOS. Treg generation was associated with ICOS/ICOSL engagement and was abrogated by antagonist anti-ICOS and anti-ICOSL antibodies. Interactions between Tregs and FL B cells resulted in ICOSL downregulation on FL B cells. Our results highlight a key role for Tregs in FL pathogenesis and suggest that targeting the ICOS/ICOSL pathway may be a promising immunotherapy for FL treatment. Cancer Res; 76(16); 4648-60. ©2016 AACR.
PTU-010 Trans-anal submucosal endoscopic resection – taser compilation
Authors: ZP Tsiamoulos, J Warusavitarne, T Elliott, R Rameshshanker, BP Saunders
Journal: Gut (2015)

<h3>Introduction</h3> Current surgical/trans-anal and endoscopic techniques for resection of very large (&gt;5 cm)/complex rectal polyps (CRP’s) remain problematic due to technical complexity, inadequate excision and safety issues. <h3>Method</h3> Four patients with complex benign rectal polyps, two circumferential lesions and two with severe submucosal scarring due to multiple previous resection attempts were resected utilising the TASER approach. Prior to referral, all patients were being considered for proctectomy due to failed conventional endoscopic therapy. Trans-Anal-Submucosal-Endoscopic-Resection (TASER) involves placing the Gelport-Path platform across the anus to facilitate three air-tight rectal access ports. An endoscope through one port was then used to provide vision, gas insufflation and carry resection knives, snares and haemostatic devices while the two remaining ports were used for laparoscopic retractors, suturing or cutting devices. The purpose of this case series is to demonstrate the feasibility of this new hybrid, endo-surgery approach. <h3>Results</h3> Four TASER procedures were employed in 4 patients (mean age 63 years, 2 males/2 females) with 4 CRPs (mean size 75 mm/range, 50–130 mm). Complete excision was achieved in all polyps. Mean procedure time was 185 min/range, 65–480 min. TASER-aided resection was performed utilising Endoscopic Submucosal Dissection/ESD in 1/4, ESD+Piecemeal-Endoscopic-Mucosal-Resection/P-EMR in 2/4 and ESD + Trans-Anal-Minimally Invasive Surgery/TAMIS in 1/4. In the two cases of severe submucosal fibrosis, dissection resulted in small full-thickness, extra-peritoneal defects that were easily repaired with suturing and clips. No episodes of bacteremia or delayed bleeding occurred. All patients had an uneventful recovery and were discharged within 24 hrs. First follow up colonoscopy showed slight luminal narrowing without structuring and no recurrence in 2 patients and first follow up is pending in the other two cases. <h3>Conclusion</h3> TASER appears to be a safe and effective endo-surgical approach providing a flexible platform for the minimally-invasive management of extensive/recurrent rectal polyps, previously destined for surgery. <h3>Disclosure of interest</h3> None Declared.
Surveillance of enterohaemorrhagic E. coli (EHEC) infections and haemolytic uraemic syndrome (HUS) in Europe
Authors: A Ammon
Journal: Eurosurveillance (1997)

Since they were first described, Escherichia coliO157: H7 and other related enterohaemorrhagic E. coli(EHEC) have become known as a major infectious cause of bloody diarrhoea. These E. coliproduce one or more shiga-toxins (stx) or Vero cytotoxins. Strictl
Evaluation of a 3-hydroxypyridin-2-one (2,3-HOPO) Based Macrocyclic Chelator for <sup>89</sup>Zr<sup>4+</sup> and Its Use for ImmunoPET Imaging of HER2 Positive Model of Ovarian Carcinoma in Mice
Authors: Jeff N.Tinianow, Darpan N. Pandya, Sylvie L. Pailloux, Annie Ogasawara, Alexander N. Vanderbilt, Herman S. Gill, Simon-P. Williams, Thaddeus J. Wadas, Darren Magda, Jan Marik
Journal: Theranostics (2016)

A novel octadentate 3-hydroxypyridin-2-one (2,3-HOPO) based di-macrocyclic ligand was evaluated for chelation of 89 Zr; subsequently, it was used as a bi-functional chelator for preparation of 89 Zr-labeled antibodies.Quantitative chelation of 89 Zr 4+ with the octadentate ligand forming 89 ZrL complex was achieved under mild conditions within 15 minutes.The 89 Zr-complex was stable in vitro in presence of DTPA, but a slow degradation was observed in serum.In vivo, the hydrophilic 89 Zr-complex showed prevalently renal excretion; and an elevated bone uptake of radioactivity suggested a partial release of 89 Zr 4+ from the complex.The 2,3-HOPO based ligand was conjugated to the monoclonal antibodies, HER2-specific trastuzumab and an isotypic anti-gD antibody, using a p-phenylene bis-isothiocyanate linker to yield products with an average loading of less than 2 chelates per antibody.Conjugated antibodies were labeled with 89 Zr under mild conditions providing the PET tracers in 60-69% yield.Despite the limited stability in mouse serum; the PET tracers performed very well in vivo.The PET imaging in mouse model of HER2 positive ovarian carcinoma showed tumor uptake of 89 Zr-trastuzumab (29.2 ± 12.9 %ID/g) indistinguishable (p = 0.488) from the uptake of positive control 89 Zr-DFO-trastuzumab (26.1 ± 3.3 %ID/g).In conclusion, the newly developed 3-hydroxypyridin-2-one based di-macrocyclic chelator provides a viable alternative to DFO-based heterobifunctional ligands for preparation of 89 Zr-labeled monoclonal antibodies for immunoPET studies.
Rheumatic Heart Disease Detected by Echocardiographic Screening
Authors: Rachel Webb, Nigel J Wilson, Diana Lennon
Journal: New England Journal of Medicine (2007)

for the Joint Outcome Study Authors Globe DR, Curtis RG, Koerper MA, HUGS Steering Committee. Utilization of care in haemophilia: a resource-based method for cost analysis from the Haemophilia Utilization Group Study (HUGS). Haemophilia 2004;10:Suppl 1:63-70. Ullman M, Hoots WK. Assessing the costs for clinical care of patients with high-responding factor VIII and IX inhibitors. Haemophilia 2006;12:Suppl 6:74-9. 1.
Near-fatal hemorrhagic shock after endoscopic ultrasound-guided liver biopsy
Authors: Galab Hassan, Anand Sahai, Sarto Paquin
Journal: Endoscopy (2015)

Endoscopic ultrasound (EUS)-guided liver biopsy with a 19-gauge fine-needle aspiration (FNA) needle is safe and provides excellent diagnostic yield [1] [2] [3] [4]. Post-procedural bleeding is a well-known complication of liver biopsy [5]. Although it is reasonable to assume that similar complications may arise after EUS-guided liver biopsy, no complications of this nature have been reported thus far.
AB0705 Psychopathologic Involvement in Systemic Sclerosis: A Pilot Study
Authors: J. Meijs, E. Ercan, E. Baptist, N. van der Wee, O. Tritanon, M. van Buchem, T. Huizinga, A. Schouffoer, H. Middelkoop, J. de Vries-Bouwstra
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Involvement of the brain in systemic sclerosis (SSc) could be suspected given the presence of disturbances on cerebrovascular imaging or mental dysfunction, including disorders of cognition or mood. It is important to confirm this since the intervention of first choice for cognitive disorders is highly depending on the pathophysiology. <h3>Objectives</h3> To investigate whether mental complaints in patients with SSc are related to organic brain dysfunction. <h3>Methods</h3> Twenty SSc patients with self-reported mental complaints, including concentration problems, fatigue, memory loss, or depression, were cross-sectionally assessed by neuropsychological testing, psychiatric evaluation and magnetic resonance imaging (MRI) of the brain. All patients completed the Hospital Anxiety and Depression Scale, Dissociation Experience Scale, a screenings tool for fatigue (MFI-20), Short Form-36 and Neuropsychiatric Inventory. Patients were compared with 20 age and sex matched healthy controls. <h3>Results</h3> Patients and healthy controls did not differ with respect to sociodemographic characteristics. In 5 SSc patients cognitive dysfunction was considered questionable by the neuropsychologist. Patients performed slightly worse on cognition tasks as compared to healthy controls, but all test results were within the normal range. The MRI showed small white matter hyperintensities (WMH) in 18 patients and in 15 healthy controls. The neuropsychological tests were completely normal within those 15 healthy controls. Thirteen SSc patients with WMH on MRI, had normal neuropsychological tests and no mood disorder. Four patients with WMH had a mood disorder. <h3>Conclusions</h3> Based on this pilot study, SSc patients show slight disturbances of mental functioning as compared to healthy controls, but their performance is within the normal range. No clear association between mental dysfunction and organic brain abnormalities could be detected. In case of mental dysfunctioning in SSc patients, we propose psychological intervention, starting with psychoeducation and in some cases cognitive-behavioural therapy, is the best treatment. <h3>Disclosure of Interest</h3> J. Meijs Grant/research support from: Jessica Meijs was supported by an unrestricted educational grant of Actelion Pharmaceuticals Nederland BV (Woerden, The Netherlands)., E. Ercan: None declared, E. Baptist: None declared, N. van der Wee: None declared, O. Tritanon: None declared, M. van Buchem: None declared, T. Huizinga: None declared, A. Schouffoer: None declared, H. Middelkoop: None declared, J. de Vries-Bouwstra: None declared
Global Progress Toward Rubella and Congenital Rubella Syndrome Control and Elimination — 2000–2014
Authors: Gavin B. Grant, Susan E. Reef, Alya Dabbagh, Marta Gacic-Dobo, Peter M. Strebel
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

National Gay Men's HIV/AIDS Awareness Day is observed each year on September 27 to direct attention to the ongoing and disproportionate impact of human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) on gay, bisexual, and other men who have sex with men (MSM) in the United States.MSM represent approximately 2% of the U.S. population (1).However, in 2013, MSM accounted for 67% of all new HIV diagnoses, including 3% who were also injection drug users (2).In 2011, among all persons living with HIV infection, an estimated 647,700 (54%) were MSM (3).Of these MSM, an estimated 84% received a diagnosis of HIV, 38% were in HIV medical care, antiretroviral therapy was prescribed for 35%, and 30% achieved viral suppression.CDC supports efforts to reduce HIV infection among MSM, including HIV prevention services that increase diagnosis of HIV infection, support the linkage and engagement of MSM in care and treatment, and reduce the risk for acquiring and transmitting HIV.Additional information about these efforts is available at http://www.cdc.gov/hiv/risk/gender/msm.
Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission
Authors: DS Snyder, NJ Chao, MD Amylon, J Taguchi, GD Long, RS Negrin, AP Nademanee, MR O'Donnell, GM Schmidt, AS Stein
Journal: Blood (1993)
Prenatal Antidepressant Use and Risk of Autism Spectrum Disorders in Children
Authors: Yusuf Cem Kaplan, Elif Keskin-Arslan, Selin Acar
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Antiviral Agents
Authors: Jan Koch-Weser, Martin S. Hirsch, Morton N. Swartz
Journal: New England Journal of Medicine (1980)

InterferonIN 1957, Isaacs and Lindenmann described the in vitro production of a soluble antiviral mediator, interferon, by virus–infected cells.57 Since then, much has been learned concerning the properties and actions of what is now recognized to be a group of cellular glycoproteins, the interferons.58 , 59 Only recently have sufficient quantities of human leukocyte interferon become available to permit controlled clinical studies.Antiviral Spectrum and Mode of ActionInterferons are relatively species specific, acting mainly on the species of animal cells in which they are induced. However, they are not virus specific but capable of interfering with a wide variety of . . .
THU0256 Septic Arthritis: Retrospective Case Series
Authors: M. Uriarte, C.A. Egües, N. Errazquin, C.F. Meneses, I. Hernando, J. Belzunegui
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Overall, bacteria are the most common cause of infectious arthritis. Its incidence appears to be increasing in developed countries with an annual incidence of 2-6 cases/100,000 inhabitants. It is more prevalent in extreme ages, and in patients with comorbidities. The 40% of patients with septic arthritis have a prior arthropathy. The most common causative microorganism is Staphylococcus aureus, followed by Streptococcus group, of which the Streptococcus pyogenes is the most involved. In 75% of cases the infection is acquired through the blood and in 80% of cases affects a single joint. The knee is the most affected joint. The diagnosis is confirmed by isolating the organism in synovial fluid and due to its high morbidity and mortality treatment with intravenous antibiotics should be started promptly. <h3>Objectives</h3> To describe the demographic, clinical and laboratory features of patients with septic arthritis, with microorganism identified in synovial fluid and/or blood cultures between January 1985 and December 2014 at the University Hospital of Donostia (Guipuzcoa, Spain). <h3>Methods</h3> Retrospective research of clinical data of patients diagnosed with septic arthritis between January 1985 and December 2014. Patients without microorganism identified in synovial fluid and/or blood cultures were excluded. Variables included were: age, sex, potential risk factors for infection, previous joint aspiration, history of arthropathy, clinical features, identified microorganism, affected joint, laboratory and imaging tests and the presence of osteomyelitis. <h3>Results</h3> A total of 259 patients were enrolled with a diagnosis of septic arthritis and microorganism identified well in synovial fluid and/or blood. The 67.20% of the patients were male and the median age was 61 (IQR=31). Risk factors were identified in 72.7% of patients. The 39.92% of patients had previous arthropathy and 12.86% had history of previous arthrocentesis. The most common causative agent was Staphylococcus Aureus in 62.89% of cases, followed in frequency by Streptococcus group (21.88%) and Escherichia coli (5.47%). In 76.11% of cases the diagnosis was made by isolation of germ in synovial fluid and in 19.03% of cases with isolation in synovial fluid and blood cultures. The knee joint was affected in 51.02% of cases. Pain and swelling were present in most patients, 98.78% and 91.46% respectively. The 64.61% had fever. Osteomyelitis was present in 9.96% of patients. Conservative treatment was the most used (76.86%) and 23.14% required surgery at some point. <h3>Conclusions</h3> –The most common causative agent was S. aureus. –Almost half of the patients had previous arthropathy –A small percentage of patients had osteomyelitis. <h3>Disclosure of Interest</h3> None declared
Bortezomib and Low-Dose Dexamethasone with or without Continuous Low-Dose Oral Cyclophosphamide for Primary Refractory or Relapsed Multiple Myeloma: Final Results of a National Multicenter Randomized Controlled Phase III Study
Authors: Martin Kropff, Martin Vogel, Andrea Kreter, Rudolf Schlag, Lothar Müller, Rudolf Weide, Wolfgang Knauf, Thomas Decker, Heinrich Fiechtner, Georgi Kojouharoff, Stephan Kremers, Wolfgang E Berdel
Journal: Blood (2014)