THE USE OF BAL (2,3-DIMERCAPTOPROPANOL) IN THE TREATMENT OF AGRANULOCYTOSIS FOLLOWING INTENSIVE ARSENOTHERAPY FOR SYPHILIS
Authors: H L HOLLEY
Journal: Annals of Internal Medicine (1947)

Article1 August 1947THE USE OF BAL (2,3-DIMERCAPTOPROPANOL) IN THE TREATMENT OF AGRANULOCYTOSIS FOLLOWING INTENSIVE ARSENOTHERAPY FOR SYPHILISHOWARD L. HOLLEY, M.D.HOWARD L. HOLLEY, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-27-2-231 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptToxic reactions in man due to the systemic action of arsenic have been observed occasionally during routine arsenotherapy for syphilis. The recent widespread use of highly intensive schedules of anti-syphilitic treatment has markedly increased the incidence of these reactions. One of these, agranulocytosis, once considered rare, has occurred more frequently since these newer methods of arsenotherapy for syphilis have been introduced. This reaction, characterized by a disappearance of the granulocytes from the blood stream, is due possibly to the toxic action of arsenic on the blood forming organs. As a result of the loss of the granulocytes, infections occur more...Bibliography1. LOVEMAN AB: Toxic agranulocytosis, purpura hemorrhagica and aplastic anemia following the use of arsphenamines, Ann. Int. Med., 1932, v, 1238. Google Scholar2. REZNIKOFF P: Agranulocytosis and leukopenia, Jr. Am. Med. Assoc., 1940, cxv, 128. Google Scholar3. WATERSSTOCK LLC: BAL (British Anti-Lewisite), Science, 1945, cii, 601-606. CrossrefGoogle Scholar4. EAGLE H: The systemic treatment of arsenic poisoning with BAL (2,3-dimercaptopropanol), Jr. Ven. Dis. Inf., 1946, xxvii, 114. Google Scholar5. VOEGTLINDYERLEONARD CHACS: Mechanisms of the action of arsenic upon protoplasm, Pub. Health Rep., 1923, xxxviii, 1882-1912. CrossrefGoogle Scholar6. DOAN CA: The neutropenic state, Jr. Am. Med. Assoc., 1932, ic, 194. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Birmingham, Alabama*Received for publication January 27, 1947.From the Department of Medicine, University of Alabama Medical School, Birmingham, Alabama.The drug for this study was furnished by the United States Public Health Service Research Center at Johns Hopkins University, Baltimore, Maryland. A portion of this work was done while the author was a member of the United States Public Health Service Reserve.Acknowledgment is made to Dr. James S. McLester, for his review and suggestions in the preparation of this article; and to Dr. Samuel Fisher and Dr. George Fein, under whose jurisdiction most of these cases were treated. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBLOOD DYSCRASIAS SECONDARY TO GOLD: WITH A CASE OF HYPOPLASTIC ANEMIA CURED BY SPLENECTOMY*HENRY J. L. MARRIOTT, B.M. (Oxon.), H. RAYMOND PETERS, M.D., F.A.C.P.SyphilisDermatologyBAL 1 August 1947Volume 27, Issue 2Page: 231-238KeywordsArsenicBloodBronchoalveolar lavageDrugsGranulocytesHealth services researchMedical servicesRiversSyphilis ePublished: 1 December 2008 Issue Published: 1 August 1947 PDF downloadLoading ...