tbuckley/cabot-search huggingface dataset:
Use of a murine model of NSCLC to evaluate the role of the microRNA-200 family in regulating EMT and metastasis
Authors: D. L. Gibbons, W. Lin, C. Creighton, S. Zhang, G. Lozano, J. Kurie
Journal: Journal of Clinical Oncology (2009)

11006 Background: Non-small cell lung cancer (NSCLC) is the leading cause of cancer death worldwide, primarily due to metastatic disease. Unfortunately, we lack a clear understanding of the molecular and cellular basis for lung cancer metastasis, partly because the experimental study is hampered by lack of good models. Methods/Results: To address this deficiency we have developed an experimental murine model of metastatic NSCLC using cell lines derived from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-ras G12D and p53 R172H . An expression signature derived from the spontaneous metastatic tumors in these animals is prognostic when applied to a large series of early-stage patient tumors, illustrating that the model recapitulates features of the human disease. Combined mRNA and microRNA profiling of highly metastatic subcutaneous tumors versus non-metastatic tumors revealed a signature for the epithelial-to-mesenchymal transition (including increases in known EMT-inducing transcription factors and down-regulation of genes responsible for maintenance of epithelial polarity) and associated loss of the microRNA-200 family (miR-141, 200a, 200b, 200c &amp; 429) expression. Forced expression of the miR-200 family produced a more epithelial cell phenotype and associated changes in the ability of the cancer cells to respond to EMT-inducing stimuli such as TGFβ. We believe this to be a mechanism whereby changes in the tumor microenvironment influence tumor cell state and ability to undergo metastasis. Conclusions: New therapeutic targets to address the problem of metastatic NSCLC will only emerge from a better understanding of the tumor biology. Using this experimental animal model has revealed a role for EMT in the pathogenesis of the disease and the microRNA-200 family as regulators of the cellular switch. We are currently working to understand the microenvironment regulation of the miR-200 members. This work should provide new insights into the cell biology of tumor progression and metastasis, while generating new potential targets for therapy of metastatic disease. [Table: see text]
Occasional Lectures Delivered during Session 1913-1914 - October 20, 1913: On Some of the Recent Advances in the Field of Microbiology; with Demonstrations of the Pure Cultures of various Spirochætes, of the Viruses of Rabies and Poliomyelitis, and of Treponema pallidum in the Brains of General Paralytics
Authors: Hideyo Noguchi
Journal: Journal of the Royal Society of Medicine (1914)
All-trans-retinoic acid: what is it good for?
Authors: R P Warrell
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.11.1659 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1403047 All-trans-retinoic acid: what is it good for? R P Warrell JrxR P Warrell JrSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.11.1659 First Page PDF © 1992 by American Society of Clinical Oncology
Lack of efficacy of clozapine monotherapy in refractory obsessive- compulsive disorder
Authors: C J McDougle, L C Barr, W K Goodman, G H Pelton, S C Aronson, A Anand, L H Price
Journal: American Journal of Psychiatry (1995)

The authors assessed the efficacy of clozapine monotherapy for adults with treatment-resistant obsessive-compulsive disorder.Twelve adults with refractory obsessive-compulsive disorder participated in a 10-week, open-label, systematic trial of clozapine. They were assessed with the Yale-Brown Obsessive Compulsive Scale, the Hamilton Depression Rating Scale, and the global improvement item of the Clinical Global Impression (CGI) scale.None of the 10 patients who completed the trial was a responder. No significant change was observed in obsessive-compulsive or depressive symptoms or in scores on the CGI global improvement item.These findings suggest that clozapine monotherapy is not effective for most adult patients with treatment-resistant obsessive-compulsive disorder.
Familial alcoholism in primary unipolar major depressive disorder
Authors: G Winokur, W Coryell
Journal: American Journal of Psychiatry (1991)

Some studies have suggested relationships between depression in probands and alcoholism in relatives. Other studies have not, but some of these have used inappropriate control groups or failed to divide probands by sex.The present study controlled for sex of probands and used several comparison groups to further explore the familial relationship between depression and alcoholism. Diagnoses for 723 directly interviewed relatives of 326 probands with primary unipolar depression were compared to diagnoses in 469 control subjects chosen by an acquaintanceship method to demographically resemble the relatives of affective disorder probands. Diagnoses in the uninterviewed relatives of both control and depressed subjects were used for comparisons as well.Results indicated higher rates of alcoholism in the families of depressed women but not in the families of depressed men.This familial association between alcoholism and depression may be the result of either genetic or environmental factors or an interaction between the two.
The Survival of the Mammary Tumor Milk Agent in Cultures of Heterologous Cells&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Mary A. Pikovski
Journal: JNCI Journal of the National Cancer Institute (1953)

The Survival of the Mammary Tumor Milk Agent in Cultures of Heterologous Cells2 Mary A. Pikovski Mary A. Pikovski Department of Experimental Pathology (Cancer Laboratories), Hebrew University, Jerusalem, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar 3The author wishes to express her sincere thanks to Dr. Anne Rosin, Lecturer in Pathology at the Hebrew University Medical School, for her co-operation and kind help in the study of the histologie sections, and to Professor I. Berenblum for his kind interest and valuable advice. Author Notes JNCI: Journal of the National Cancer Institute, Volume 13, Issue 5, April 1953, Pages 1275–1282, https://doi.org/10.1093/jnci/13.5.1275 Published: 01 April 1953 Article history Received: 14 August 1952 Published: 01 April 1953
Immunohistochemical Analysis of Interleukin-1β–Converting Enzyme/Ced-3 Family Protease, CPP32/Yama/Caspase-3, in Hodgkin's Disease
Authors: Mukesh Chhanabhai, Stanislaw Krajewski, Maryla Krajewska, Hong-Gang Wang, John C. Reed, Randy D. Gascoyne
Journal: Blood (1997)
Refractory definitions of tumor response.
Authors: S M Grunberg
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.6.2291 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9626241 Refractory definitions of tumor response. S M GrunbergxS M GrunbergSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.6.2291 PDF "Refractory definitions of tumor response.." Journal of Clinical Oncology, 16(6), pp. 2291–2292© 1998 by American Society of Clinical Oncology
AB0143 Uncontrolled Expression of S100A8 Homodimers in the Absence of S100A9 Exacerbates TNFα-Mediated Psoriatic-Like Arthritis
Authors: S. Thurainayagam, V. Wixler, S. Hermann, J. Roth, T. Vogl
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Psoriasis is a chronic autoimmune disorder frequently associated with arthritis (PsA). Alarmins S100A8 (myeloid related protein, MRP8) and S100A9 (MRP14), expressed in granulocytes, monocytes and activated keratinocytes, are highly up-regulated in psoriatic skin and synovium. Analysis of mice that are deficient for S100A9 demonstrated a pivotal role of these proteins for many inflammatory diseases (1). Notably, although <i>S100a8</i> mRNA remains unchanged in S100A9-deficient (S100A9-/-) mice, S100A8 protein expression is abrogated, thus generating a functionally double knockout mouse model (3). Moreover, these mice show reduced inflammatory activities in several mouse models of infection and inflammation. Recently we generated doxycycline-inducible human TNFa–transgenic mice (ihTNFtg) which display the major features of inflammatory arthritis with fore paws being prominently affected (2). <h3>Objectives</h3> To investigate the role of S100A8/S100A9 on the disease progression during TNFα-mediated psoriatic-like arthritis. <h3>Methods</h3> hTNFα was induced in ihTNFtgxS100A9-/- mice by doxycycline and alterations of body weight, paw swelling and grip strength were examined compared to ihTNFtg mice. In addition, <sup>18</sup>F-FDG whole body PET scans were performed to quantify inflammation in these mice. S100A8 expression was analysed in various organs, skin, BMC and blood cells by IHC, Western blotting and FRI. <h3>Results</h3> Unexpectedly, we observed an enhanced disease progression in ihTNFtgxS100A9-/- mice as loss of body weight and grip strength, increased paw swelling and cartilage destruction compared to ihTNFtg mice. Moreover, <sup>18</sup>F-FDG-PET imaging also illustrated an increased inflammatory activity mainly in DIP joints and organ impairment. Interestingly, we clearly saw a re-expression of pro-inflammatory S100A8 protein in bone marrow, blood, skin and nail keratinocytes. <h3>Conclusions</h3> We hypothesize that in the absence of its binding partner S100A9, constitutively active S100A8 homodimers aggravate TNFα-mediated psoriatic-like arthritis. Our data indicate a complex S100A8/S100A9 regulatory mechanism of an alarmin-driven inflammation. <h3>References</h3> Vogl, T. et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13, 1042-1049 (2007). Retser, E. et al. Doxycycline-induced expression of transgenic human tumor necrosis factor alpha in adult mice results in psoriasis-like arthritis. Arthritis Rheum 65, 2290-2300 (2013). Manitz, M. P. et al. Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol 23, 1034-1043 (2003). <h3>Disclosure of Interest</h3> None declared
Abstract 2249: TERT promoter mutation as poor prognosis marker in glioblastoma via sphere formation and self- renewal capacity
Authors: Jae-Ho Lee, Hyunsu Lee, Seon Rang Woo, Kyeung-Min Joo, KeonUk Park
Journal: Cancer Research (2015)

Abstract Telomerase reverse transcriptase (TERT) activity was increased allowing the maintenance of telomere length in cancers. TERT promoter mutation has been reported in a variety of cancers, especially in glioblastoma (GBM) with high frequency. In present study, we screened TERT promoter mutation in 25 GBMs and analyzed the results with their respective genetic profile and its renewal capacity by in vitro sphere formation. TERT promoter mutation (C228T, C250T) was found in 16 of 25 GBMs (64.0%) and was associated with male (p &amp;lt; 0.01). They showed inverse correlations with IDH1 and ATRX mutations and a positive correlation with EGFR amplification though it did not show significance. GBM with sphere formation harbored higher frequency of TERT promoter mutation (91.6%) than those without sphere formation (27.3%; p = 0.01), which suggest that TERT mutation promotes self-renewal capacity of GBM. GBM with TERT mutations showed a shorter survival than those without TERT mutation in univariate analysis (median, 83.6 vs. 123.8 weeks; p = 0.045). These results suggested that TERT promoter mutation affect poor prognosis of GBM via promoting self- renewal capacity. Citation Format: Jae-Ho Lee, Hyunsu Lee, Seon Rang Woo, Kyeung-Min Joo, KeonUk Park. TERT promoter mutation as poor prognosis marker in glioblastoma via sphere formation and self- renewal capacity. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2249. doi:10.1158/1538-7445.AM2015-2249
Pneumomediastinum caused by hypopharyngeal perforation during endoscopic ultrasound-guided fine-needle aspiration
Authors: Tomoya Iida, Takeya Adachi, Suguru Nakagaki, Takashi Yabana, Akira Goto, Yoshihiro Kondo, Hiroshi Nakase
Journal: Endoscopy (2016)

A 78-year-old man presented with a major complaint of back pain. A contrast-enhanced computed tomography (CT) scan showed a 2-cm hypovascular, irregular, tumorous lesion in the body of the pancreas that was invading the celiac, splenic, and common hepatic arteries. Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) was planned.
Brain SPECT and MRI Findings in a Uremic Patient With Parkinsonism
Authors: Eun Kyoung Choi, Jin Kyoung Oh, Yong-An Chung, In-Uk Song
Journal: Clinical Nuclear Medicine (2015)

Parkinsonism associated with basal ganglia pathology represents a rare complication in uremia patients, characterized by acute hyperkinetic or hypokinetic extrapyramidal movement disorders. We herein present brain SPECT and MR findings of uremic patients with end-stage renal failure exhibiting parkinsonian symptoms. The bilateral basal ganglia exhibited decreased uptake on SPECT, and abnormal signals on MR, suggesting pathology.
The International Index is not useful in the classification of low-grade lymphoma.
Authors: A Avilés
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.12.2766 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7989955 The International Index is not useful in the classification of low-grade lymphoma. A AvilésxA AvilésSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.12.2766 PDF "The International Index is not useful in the classification of low-grade lymphoma.." Journal of Clinical Oncology, 12(12), pp. 2766–2768© 1994 by American Society of Clinical Oncology
Past and current dermatological status of yusho patients.
Authors: H Urabe, M Asahi
Journal: Environmental Health Perspectives (1985)

Skin symptoms of "yusho" and their change thereafter are described. In the early stage, skin eruptions were the most prominent and impressive features of yusho. Acneiform eruptions and pigmentation were most conspicuous. With the passage of time, there is some improvement and most patients now have few eruptions, except for the severely intoxicated group. As for blood PCB analysis, the severely intoxicated group who showed intensive skin symptoms showed "pattern A"--a typical specific yusho pattern. The blood PCB patterns of each patient were stable with no alteration after many years and, on the other hand, the blood PCB concentrations have diminished year by year.
PWE-130 Automated cell counters for the rapid diagnosis of sbp: a comparison with microscopy
Authors: GM Fisher
Journal: Gut (2015)

<h3>Introduction</h3> The diagnosis of Spontaneous Bacterial Peritonitis (SBP) is based (via consensus) on a neutrophil count of 250/mm<sup>3</sup>. Traditionally this has been ascertained manually via light microscopy and counting chambers. Current AASLD and EASL guidelines cite recent promising validation studies of modern automated cell counters showing high diagnostic sensitivity and specificity when compared to the “gold standard” of light microscopy. A retrospective local analysis of the correlation between synchronous automated and manual ascitic leucocyte counts in cirrhotic patients was undertaken in our NHS Trust. <h3>Method</h3> All automated cell counts performed during 2014 were included in the analysis. 162 ascitic samples were identified and concurrent manual cells counts were sought. The automated counter used was the Beckman Coulter UniCel DxH 800™ cellular analysis system and the microscopy was performed using the NanoEnTek™ disposable haemocytometer. An automated leucocyte count of ≥ 0.3 × 10<sup>–9</sup>and a manual neutrophil count of ≥250 × 10<sup>–6 </sup>were deemed positive. Corresponding bacteriology results and serum albumin-ascites gradients (SAAG) were analysed. Robust linear regression, Bland-Altman and ROC analyses were undertaken in addition to calculation of sensitivity, specificity, and positive/negative predictive value of automated counts. <h3>Results</h3> 56 diagnostic paracenteses on cirrhotic patients with both automated and manual cell counts were identified. Robust linear regression of the automated count on the manual count gave an R<sup>2</sup>of 0.4 with a positive bias (non-zero intercept). Bland-Altman analysis confirmed this bias and identified spontaneous outliers. ROC analysis gave an optimal operating point of sensitivity 0.78 and specificity 0.8 at an automated count threshold of 0.35 × 10<sup>9</sup>/L. The prevalence of SBP was 7.14% with 4 cases of SBP by manual neutrophil count. 19 results were deemed false positive by the automated counter: none was falsely negative: 33 were truly negative. Sensitivity of the automated counter was 100% (95% CI: 40.23–100%) and specificity was 63.46% (95% CI: 48.96% &gt; 76.37%). Positive predictive value was 17.39% (95% CI: 5.06–38.8%) and negative predictive value was 100% (95% CI: 89.32–100%). No organisms were seen on Gram stain. Three cases of bacterascites with neutrophil counts of &lt;250/mm<sup>3</sup>all grew coagulase negative Staphylococci. No cases of culture-positive SBP were identified in this series. <h3>Conclusion</h3> In contrast to previous published validation data assessing the diagnostic accuracy of automated cell counters, local experience of automated leucocyte counts in the rapid assessment of SBP has shown an unacceptably low specificity and positive predictive value. This would lead to significant overtreatment if this assay replaced the traditional manual method in its current form. <h3>Disclosure of interest</h3> None Declared.
Serum Enzymes. III. The Significance of Abnormalities of Glycolytic Enzymes in the Serum of Cancer Patients&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Laurens P. White, M.D.
Journal: JNCI Journal of the National Cancer Institute (1958)

The abnormal serum activity of aldolase, lactic dehydrosenase, phosphohexose isomerase, and glutamic-oxalacetic transaminase, often found in patients with cancer, may decrease to normal following the administration of large amounts of protein. In some patients with liver metastases, protein administration fails to lower the serum enzyme activity. Similar studies in patients with muscular dystrophy, all with high serum activity of these enzymes, do not demonstrate any effect of protein feeding on serum enzyme activity. In cancer patients the fall in serum enzyme activity after protein feeding is not a result of enzyme inhibition by albumin or Amigen. Protein feeding in some patients with cancer may be associated with an explosive increase in the apparent rate of tumor growth.
Treatment of Fracture of the Clavicle by Internal Nail Fixation
Authors: Harold G. Lee
Journal: New England Journal of Medicine (1946)

FRACTURES of the clavicle can almost invariably be satisfactorily treated by conservative measures. The fragments unite easily and quickly, and the functional results are good, even though there may be a certain amount of residual deformity and shortening of the clavicle. In an occasional case of fracture of the outer end of the bone in which it is desirable to obtain perfect alignment and retention of the fragments, the usual closed methods of treatment are inadequate. In such fractures, intramedullary fixation of the fragments by Kirschner wire has been carried out with success, but its use is not without danger, . . .
Case report of a possible interaction between neuroleptics and carbamazepine
Authors: G L Kanter, B I Yerevanian, J R Ciccone
Journal: American Journal of Psychiatry (1984)

A 52-year-old woman with bipolar disorder, rapid-cycling type, developed delirium while taking therapeutic doses of carbamazepine and neuroleptics. Her cognitive changes were attributed to a drug interaction at the CNS level.
Natural history of male psychological health, XIII: Who develops high blood pressure and who responds to treatment
Authors: G E Vaillant, P D Gerber
Journal: American Journal of Psychiatry (1996)

This study was an effort to clarify both the psychological contributions to and the long-term consequences of uncomplicated essential hypertension.The subjects were 193 healthy college students selected as sophomores and prospectively followed for over 50 years. Independent assessments of physical and mental health were made.Although objective indices of psychopathology predicted both physical morbidity and mortality, they did not predict hypertension. When pyknic somatotype, college diastolic blood pressure, and well-integrated personality in college were controlled, no other preadult variable predicted hypertension. As expected, heart disease, obesity, and alcohol abuse were each correlated with hypertension. After roughly 20 years, 14 of the 41 men with treated hypertension were in stable remission, and 13 men had developed cardiac complications. No differences between these groups could be discerned.Over time, hypertension appeared to be more a product of biological than of psychosomatic variables. Good psychological health did not diminish the risk of hypertension.
Endoscopic resection for esophageal high grade dysplasia in a patient with cervical esophageal stricture via the transgastric approach
Authors: Yong Liu, Chun-Guang Guo, Shun He, Liyan Xue, Yue-Ming Zhang, Dong-Bing Zhao, Gui-Qi Wang
Journal: Endoscopy (2015)

Patients with head and neck cancer often have synchronous or metachronous esophageal squamous cell carcinoma or its precursor [1] [2] [3] [4]. Multimodal therapy may be necessary for patients with multiple cancers. In patients with metachronous double cancers, the prior treatment of the first primary carcinoma often affects the treatment of the second cancer [5].
Evaluation of Chemotherapeutic Agents in a New Murine Renal Carcinoma Model 2
Authors: William J. Hrushesky, Gerald P. Murphy
Journal: JNCI Journal of the National Cancer Institute (1974)

Vinblastine and 1-(2-chlorethyl)-3-cyclohexyl-1-nitrosourea (CCNU) were evaluated in a murine renal cell carcinoma model. Both drugs significantly decreased tumor weight and the percentage of distant metastases and very significantly prolonged the survival of tumor-bearing animals. Both also exhibited a dose-related effect. The therapeutic index of vinblastine was limited by signs of systemic toxicity, while the dosage of CCNU might have been limited by its tendency to suppress host immune response to tumor, based on observations of this renal tumor model. Vinblastine may prove clinically useful in early or prophylactic treatment of resected renal tumors, whereas CCNU may be very useful in prolonging survival of patients with renal tumors which have already metastasized. Therefore, both drugs, either alone or combined, may have clinical value in the treatment of metastatic renal carcinoma. Vinblastine may serve best as initial postsurgical treatment, with the addition of CCNU if metastatic disease is documented or progressive. The 3 response criteria evaluated by this model were tumor growth, tumor spread, and prolongation of survival. These seemed most clinically relevant and this model appeared to resemble closely the clinical situation of disseminated renal cell carcinoma in man.