tbuckley/cabot-search huggingface dataset:
Abstract P247: Trends in Obesity Prevalence and Predictors of Significant Weight Loss in a Large, Diverse Employee Population: The Baptist Health Employee Study
Authors: Chukwuemeka U Osondu, Ehimen C Aneni, Javier Valero-Elizondo, Joseph A Salami, Adnan Younus, Maribeth Rouseff, Sankalp Das, Henry Guzman, Thinh Tran, Gulmeena Khan, Theodore Feldman, Arthur Agatston, Emir Veledar, Khurram Nasir
Journal: Circulation (2016)

Background: Obesity has become a significant problem in the workplace, impacting health care costs to employers and employee productivity. As a result, employers have adopted various strategies to improve obesity among their employees. In this study, we examine the changes in obesity distribution in a cohort of employees of a large healthcare organization over a 3-year period and examine characteristics of employees who lost significant weight. Methods: Employees of Baptist Health South Florida (BHSF), a large not-for-profit healthcare organization, participated voluntarily in an annual Health Risk Assessment between 2012 and 2014. Only employees who participated in all 3 consecutive years were selected for this study. Height and weight from which body mass index was calculated, as well as other biometric measures were collected. The HRA also assessed current lifestyle behaviors, as well as intentions/ readiness to improve these lifestyle characteristics and behaviors including diet, exercise and weight. Obesity was categorized according to BMI as &lt; 30, 30 - 34.9 and ≥ 35.0 kg/m2. Results: A total of 7357 employees (76% females, 56% Hispanic) participated in all 3 years of the HRA under study. Five percent (n=362) of participants shifted to a lower obesity category over 2 years. After 1 year, about 10% (n=703) of participants had a 5% reduction in BMI, while at 2 years, almost 15% (n=1061) achieved a reduction in BMI of at least 5%. Over 20% of participants with a BMI &gt; 35 lost significant weight (≥5% BMI reduction). Participants who lost significant weight were more likely to have reported an intention to lose weight (OR=1.7; 1.5 - 2.0), an intention to improve their diet (OR=1.3; 1.2 - 1.5) or physical activity (OR=1.2; 1.1 - 1.4) Conclusion: Our findings suggest that intentions to improve lifestyle may be as important as improving lifestyle itself. It also highlights the need for, and the opportunity to create motivational strategies to encourage individuals to pursue healthier lifestyles.
A phase I study of RO4929097, a novel gamma secretase inhibitor, in patients with advanced solid tumors.
Authors: A. W. Tolcher, S. M. Mikulski, W. A. Messersmith, E. L. Kwak, D. Gibbon, J. Boylan, Z. X. Xu, M. DeMario, J. J. Wheler
Journal: Journal of Clinical Oncology (2010)

2502 Background: Aberrant Notch signaling is implicated in many human cancers. RO4929097 (R) is a potent, selective oral inhibitor of gamma-secretase, a key enzyme in Notch activation. Preclinically, R has shown tumor differentiation to a less transformed phenotype and efficacy in multiple xenografts. This phase I study explored R safety, PK and PD endpoints. Methods: Dosing regimens were days 1-3, 8-10 Q 3 wks (schedule A, “A”) and days 1-7 Q 3 wks (schedule B, “B”). PK sampling in cycles 1-2. PD: AB-40, angiogenic markers (including IL-6, Il-8), Notch targets (HES1) in surrogates and tumors (RPTD), and cycle 1+2 FDG- PET. Response (RECIST) was assessed Q 6 wks. Results: 89 pts have received R; A=42 (10 cohorts, 3-270 mg/d), B= 47 (10 cohorts, 3-135 mg/d fasted + 12-18 mg/d fed). Overall, R is well-tolerated. Common (>10%) related AEs were reversible fatigue, nausea, emesis, diarrhea, hypophosphatemia, pruritus, and rash; 92% were grade 1/2 with no grade 4. Only 2 pts discontinued R due to related AEs. PK: In both A and B, R exposures increased with dose for all cohorts tested. AUCs exceeded xenograft MECs at doses >= 12 mg/d in both A and B. Average T1/2 was > 20 hrs. Food had no effect on PK. At higher dose levels, reversible, time-dependent PK were observed. PD: For both A + B, serum AB-40 levels increased between 0-4 hrs post R, then decreased towards pretreatment levels by 24 hrs. Antitumor activity included neuroendocrine CA (PR, 10 cycles) and melanoma (-27%, 6 cycles). Eleven pts had FDG-PET responses (EORTC), including a PET CR in a melanoma pt. Others with prolonged therapy (5-10 cycles) included 4 sarcoma and 3 ovarian CA pts. Preliminary data (n=25) suggest lower relative predose serum IL-6 + IL-8 among responding and prolonged SD pts. Conclusions: R therapy is feasible and well-tolerated on both schedules. R T1/2 supports QD dosing. Low dose, prolonged administration may optimize R exposure and minimize time-dependent PK. A continuous dosing schedule is planned. Encouraging signs of antitumor activity (RECIST) and prolonged stable disease were observed in pts with melanoma, neuroendocrine, sarcoma, and ovarian cancers. Validation of pretreatment IL-6 and IL-8 as response predictive markers will be explored in phase I/II R trials. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Roche Genentech/OSI (not directly with Roche) Roche Chemotherapy Foundation Roche
TCTAP A-139 The Use of Thin Strut Cobalt Chromium Bare Metal Stents in Very Small Vessels Coronary Artery Disease: Is There a Role for BMS in ‘Real-World’ Practice?
Authors: Wan Azman Wan Ahmad, Muhammad Dzafir Ismail, Matthias Leschke, Matthias Waliszewski, Michael Boxberger, Imran Zainal Abidin, Ahmad Syadi Mahmood Zuhdi
Journal: Journal of the American College of Cardiology (2016)
Hysteroscopy in recurrent in-vitro fertilisation failure (TROPHY): a multicentre, randomised controlled trial
Authors: Tarek El-Toukhy, Rudi Campo, Yacoub Khalaf, Carla Tabanelli, Luca Gianaroli, Sylvie S Gordts, Stephan Gordts, Greet Mestdagh, Tonko Mardesic, Jan Voboril, Gian L Marchino, Chiara Benedetto, Talha Al-Shawaf, Luca Sabatini, Paul T Seed, Marco Gergolet, Grigoris Grimbizis, Hoda Harb, Arri Coomarasamy
Journal: The Lancet (2016)
Abstract 13490: NADPH Oxidase Nox2 Limits Hematopoietic Stem Cell Differentiation Toward Pro-Inflammatory Myeloid Cells Through Activation of AMP kinase: Role in Reparative Inflammatory Angiogenesis
Authors: Norifumi Urao, Ronald D McKinney, Tohru Fukai, Masuko Ushio-Fukai
Journal: Circulation (2011)
Association of Pre‐Pregnancy Body Mass Index, Pregnancy‐Related Weight Changes, and Parity With the Risk of Developing Degenerative Musculoskeletal Conditions
Authors: Mette Bliddal, Anton Pottegård, Helene Kirkegaard, Jørn Olsen, Jan S. Jørgensen, Thorkild I. A. Sørensen, Lene Dreyer, Ellen A. Nohr
Journal: Arthritis & Rheumatology (2015)

To examine how pre-pregnancy body mass index (BMI), parity, and pregnancy-related weight changes are associated with long-term risk of degenerative musculoskeletal conditions.A total of 79,687 mothers with singleton births from the Danish National Birth Cohort were included. Information on height and weight prior to pregnancy and 6 months postpartum as well as gestational weight gain (GWG) was obtained from telephone interviews, while parity was derived from the Danish Medical Birth Registry. Diagnoses of musculoskeletal conditions, including osteoarthritis, disc disorders, low back pain, and soft tissue disorders, were obtained from the Danish National Patient Registry. Hazard ratios (HRs) were estimated using a Cox proportional hazards regression model.The cumulative incidence of musculoskeletal conditions during a median follow-up of 12.4 years was 19.7%. The risk of musculoskeletal conditions increased with both increasing pre-pregnancy BMI and increasing parity. Compared to normal-weight first-time mothers, the highest risk was seen in obese women with >2 births (HR 1.61 [95% confidence interval 1.41-1.83]). GWG of 10-15 kg was associated with the lowest risk of musculoskeletal conditions. Compared to women with no change in weight from preconception to 6 months after childbirth (±1 BMI unit), increasing postpartum weight increased the risk of musculoskeletal conditions in normal-weight and overweight women.Our findings indicate that high pre-pregnancy BMI increases the risk of degenerative musculoskeletal conditions. Low and high GWG, higher postpartum weight retention, and especially higher parity are associated with an increased risk. Prevention of being overweight before, during, and after pregnancy may reduce the risk of development of degenerative musculoskeletal conditions among mothers.
KHF16 is a Leading Structure from <i>Cimicifuga foetida</i> that Suppresses Breast Cancer Partially by Inhibiting the NF-κB Signaling Pathway
Authors: Yanjie Kong, Fubin Li, Yin Nian, Zhongmei Zhou, Runxiang Yang, Ming-Hua Qiu, Ceshi Chen
Journal: Theranostics (2016)

Triterpenoids extracted from Cimicifuga foetida have been reported to inhibit cancer by inducing cell cycle arrest and apoptosis.In this study, KHF16 (24-acetylisodahurinol-3-O-β-D-xylopyranoside), a cycloartane triterpenoid isolated from the rhizomes of C. foetida, showed potent anti-cancer activity in multiple ERα/PR/HER2 triple-negative breast cancer (TNBC) cell lines.KHF16 significantly induces cell cycle G2/M phase arrest and apoptosis in both MDA-MB-468 and SW527 TNBC cell lines.KHF16 reduces the expression levels of XIAP, Mcl-1, Survivin and Cyclin B1/D1 proteins.Importantly, KHF16 inhibits TNFα-induced IKKα/β phosphorylation, IKBα phosphorylation, p65 nuclear translocation and NF-κB downstream target gene expression, including XIAP, Mcl-1 and Survivin, in TNBC cells.These results suggest that KHF16 may inhibit TNBC by blocking the NF-κB signaling pathway in part.
Impact of her2/neu status on survival after high-dose chemotherapy in high-risk breast cancer patients
Authors: O. Kuzhan, A. Ozet, F. Arpaci, B. Kurt, S. Komurcu, B. Ozturk, S. Ataergin, O. Gunhan
Journal: Journal of Clinical Oncology (2005)

905 Background: The role of high-dose chemotherapy and autologous hematopoietic stem cell transplantation (HSCT) in breast cancer is still controversial. This retrospective study was designed to determine the impact of HER2/neu status on disease-free survival and overall survival after HSCT in breast cancer patients with at least 10 metastatic axillary lymph nodes.Methods: Between March 1997 and June 2004, totally 54 breast cancer patients with at least 10 metastatic lymph nodes underwent high-dose chemotherapy with HSCT. Depending on immunohistochemical HER2/neu status of their archival specimens, they were divided into HER2/neu negative (n=23) and positive (n=13) groups. Patients whose archival specimens were not available for analysis were excluded from this retrospective analysis. The Kaplan-Meier method was used to estimate curves for disease-free and overall survival, and comparisons were made with use of log-rank test. Results: HER2/neu negative and positive groups were comparable regarding age, number of patients enrolled, time elapsed from diagnosis to transplantation, number of previous chemotherapy cycles, number of total nucleated cells, number of CD34+ cells harvested, history of previous radiotherapy, preparative regimens and type of malignity, hormone receptor status, family history of breast cancer, posttransplant growth factor administered, menopausal status, presence of lymphatic invasion in tumor. Transplant related mortality did not differ between groups. No statistically significant differences were detected between HER2/neu negative and positive groups in 5-year disease-free survival (%30.5 and %43.7 respectively, p=0.74) and in overall survival (%48.5 and %58.2 respectively, p=0.86). Conclusions: Although not significant statistically, the survival rate in the HER2/neu positive group seems to be superior, which is in contrast with previous studies. This may be caused by short follow-up period, small sample size and delayed immunohistochemistry staining of archival specimens. To clarify the value of the HER2/neu status in predicting outcome after high-dose chemotherapy, further prospective randomized studies are needed. No significant financial relationships to disclose.
Statistical power of negative randomized clinical trials (RCTs) presented at the American Society of Clinical Oncology (ASCO) Annual Meetings
Authors: P. Bedard, M. K. Krzyzanowska, M. Pintilie, I. F. Tannock
Journal: Journal of Clinical Oncology (2007)

6516 Background: Underpowered randomized clinical trials (RCTs) may expose participants to risks and burdens of research without scientific merit. We investigated the prevalence of underpowered RCTs presented at ASCO annual meetings. Methods: We surveyed all two-arm parallel phase III RCTs presented at the ASCO annual meeting from 1995–2003 where differences for the primary endpoint were non-statistically significant. Post hoc calculations were performed using a power of 80% and a=0.05 (two-sided) to determine the sample size required to detect a small, medium, and large effect size between the two groups. For studies reporting a proportion or time to event as a primary endpoint, effect size was expressed as an odds ratio (OR) or hazard ratio (HR) respectively, with a small effect size defined as OR/HR=1.3, medium effect size OR/HR=1.5, and large effect OR/HR=2.0. Logistic regression was used to identify factors associated with lack of statistical power. Results: Of 423 negative RCTs for which post hoc sample size calculations could be performed, 45 (10.6%), 138 (32.6%), and 333 (78.7%) had adequate sample size to detect small, medium, and large effect sizes respectively. Only 35 negative RCTs (7.1%) reported a reason for inadequate sample size. In a multivariable model, studies presented at plenary or oral sessions (p&lt;0.0001) and multicenter studies supported by a co-operative group were more likely to have adequate sample size (p&lt;0.0001). Conclusion: Two-thirds of negative RCTs presented at the ASCO annual meeting do not have an adequate sample to detect a medium-sized treatment effect. Most underpowered negative RCTs do not report a sample size calculation or reasons for inadequate patient accrual. No significant financial relationships to disclose.
Abstract P087: Ethnic and Educational Disparities in Morbid Obesity Among Employees of a Large Healthcare Organization: The Baptist Health South Florida Employee Study
Authors: Chukwuemeka U Osondu, Ehimen C Aneni, Adnan Younus, Maribeth Rouseff, Sankalp Das, Don Parris, Henry Guzman, Thinh Tran, Rehan Malik, Muhammad A Aziz, Oluseye Ogunmoroti, Theodore Feldman, Arthur S Agatston, Emir Veledar, Salim Virani, Khurram Nasir
Journal: Circulation (2016)

Background: Ethnic differences in obesity are well documented; however, the epidemiological evidence of the impact of socioeconomic and educational status on its relationship is sparse. We sought to assess the impact of educational attainment, as a proxy of socioeconomic status, on the association between ethnicity and morbid obesity (MO) among employees of Baptist Health South Florida (BHSF), a large nonprofit healthcare organization. Methods: Data was collected from employees participating in an annual Health Risk Assessment in 2014. Educational attainment was self-reported while weight, height and other biometric measures were measured in person. MO was categorized using eligibility criteria for bariatric surgery as outlined by the 1991 NIH consensus guidelines for surgery for the obese. Results: Data was collected for 9361 participants (mean age 42.8 ± 12.1 years, 74% females, 63% Hispanic). Overall, 7% meet criteria for MO (Non-Hispanic White [NHW]: 5%; Hispanics: 6%; Non-Hispanic Black [NHB]: 12%). A lower education was associated with a greater prevalence of morbid obesity (Post graduate/ professional: 4.2%; completed college: 5.2%; some college or lower: 9.8%) The highest (18%) and lowest (4%) prevalence of MO were observed in NHB with some college education or lower (SCL), and in Hispanics with post-graduate or professional educational (PG) attainment respectively. Among PG, compared to NHW, the odd ratios (95% CI) for presence of MO among NHB was 1.3 (0.6 - 2.5). Conversely, the respective MO risk for NHB vs. NHW was 4 fold higher (2.5 - 6.4) among those with SCL. Interaction of ethnicity and educational attainment for predicting MO was significant (p &lt;0.05) adjusting for age and sex. Conclusion: Underlying differences in educational status significantly impact ethnic disparities in morbid obesity. The co-existing influence of education and racial disparities should be jointly addressed to maximize yield of future wellness efforts aimed at optimizing CV health.
TCTAP C-081 After Recent Coronary Artery Bypass Grafting and Left Internal Mammary Artery Serious Anastomotic Intimal Hyperplasia, Native Left Anterior Descending Branch Was Deal with Drug Eluting Balloon by the Support of Intra-aortic Balloon Pump
Authors: He Chen, Jinqing Yuan, Yue-Jin Yang
Journal: Journal of the American College of Cardiology (2016)
Are COPD and cardiovascular disease fundamentally intertwined?
Authors: Mona Bafadhel, Richard E.K. Russell
Journal: European Respiratory Journal (2016)

Comorbidities and chronic obstructive pulmonary disease (COPD) are ubiquitous, with cardiovascular disease being the most common and significant [1, 2]. Numerous cohort studies have demonstrated an increased risk of cardiovascular-related mortality in patients with COPD [3–6]. Interestingly, this association is often seen in mild and moderate COPD [4]. It is both disappointing and depressing that both the management of cardiovascular disease and the assessment of risk in patients with COPD is repeatedly suboptimal [7]. Defining risk for any individual is likely to lead to an improvement in recognition and, ultimately, risk management and prognosis [8]. In an age where identification of risk is as important as causality, we must challenge the status quo . In this issue of the European Respiratory Journal , Rabinovich et al . [9] report the results of their study of plasma desmosine as a marker of cardiovascular risk in COPD. The amino acids desmosine and isodesmosine are involved in elastin cross-linking, have utility as a measure of elastin breakdown [10], and may have value in determining both risk of cardiovascular disease and a link to a possible causal mechanism. Elastin loss may be the link between COPD and cardiovascular disease <http://ow.ly/YVwFC>
Medical resource use and expenditure in patients with chronic heart failure: a population‐based analysis of 88 195 patients
Authors: Nuria Farré, Emili Vela, Montse Clèries, Montse Bustins, Miguel Cainzos‐Achirica, Cristina Enjuanes, Pedro Moliner, Sonia Ruiz, Jose Maria Verdú‐Rotellar, Josep Comín‐Colet
Journal: European Journal of Heart Failure (2016)
Aortic Intracardiac Echocardiography Guided Septal Puncture During Mitral Valvuloplasty
Authors: Emre Akkaya, Ertan Vuruşkan, Ali Zorlu, İsa Sincer, Mehmet Küçükosmanoğlu, İdris Ardıç, Mehmet Birhan Yılmaz
Journal: Journal of the American College of Cardiology (2013)
David Oliver: Good medical leaders
Authors: David Oliver
Journal: BMJ (2016)

I welcome the growing recognition of the importance of medical leadership for quality services for patients.1 2 3 Still, serial critics question medical leaders’ visibility, approaches, and independence. During the current contract dispute, for example, aggrieved junior doctors have castigated those in senior roles for being too timid or status conscious to risk speaking out.

Senior medical leaders themselves have joined in. Mark Newbold criticised what he considered a failure of collective, constructive leadership.4 Peter Lees highlighted a tendency to “pitch professional against politician” and of doctors not to engage with the …
Characteristics of “Hybrid”-Type Clonal Cell Lines Obtained From Mixed Cultures &lt;italic&gt;In Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: G. Barski, FR. Cornefert
Journal: JNCI Journal of the National Cancer Institute (1962)

In confirmation of previous data, association in vitro of proliferating cultures of high-cancer N1- and low-cancer N2-type cells, derived from NCTC 2472 and NCTC 2555 clonal mouse cell lines, respectively, resulted in the appearance and accumulation of a new type of high polyploid “M” cells. Cells of this type were not observed in Nl or N2 cultures cultivated separately. Clones of M cells were obtained either directly from combined N1 + N2 cultures in vitro or from tumors produced by inoculation of C3H mice with mixed-cell populations. Karyotypes and biological behavior were similar for the 15 clonal M cell lines isolated from both origins. Some morphological and biological traits were common for the M and low-cancer N2 cells, but their malignancy approximated that of N1 cells. The “hybrid” characteristics of M cells remained stable during observation periods of nearly 1 year.
Prosecution of US psychologists who ran CIA torture program moves a step closer
Authors: Owen Dyer
Journal: BMJ (2016)

Two psychologists who designed and managed the now defunct torture program of the US Central Intelligence Agency (CIA) may be sued by their victims after a federal judge allowed the case to move forward.

James Mitchell and John “Bruce” Jessen—former employees of the US Air Force Survival School—conducted dozens of torture sessions. The company they formed, Mitchell Jessen and Associates, hired and deployed 60 private interrogators and received over $81 million in payments from the US government.1 The incoming Obama administration ended their contract in 2009.

Mitchell and Jessen are being sued by the American …
Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma
Authors: Nakhle S. Saba, Delong Liu, Sarah E. M. Herman, Chingiz Underbayev, Xin Tian, David Behrend, Marc A. Weniger, Martin Skarzynski, Jennifer Gyamfi, Lorena Fontan, Ari Melnick, Cliona Grant, Mark Roschewski, Alba Navarro, Sílvia Beà, Stefania Pittaluga, Kieron Dunleavy, Wyndham H. Wilson, Adrian Wiestner
Journal: Blood (2016)
TCTAP A-126 The Identification of Novel Biomarkers of Clopidogrel High on Treatment Platelets Reactivity Using Pharmacometabonomics Analysis of Plasma in Coronary Artery Disease Patients
Authors: Arwa Mohamed Amin Mostafa, Lim Sheau Chin, Hamza Mohamed Amin Mostafa, Muhamad Ali S.K. Abdul Kader, Dzul Azri Mohamed Noor, Yuen Kah Hay, Baharudin Ibrahim
Journal: Journal of the American College of Cardiology (2016)
Case 4-1979
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, William P. Creger, John C. Long
Journal: New England Journal of Medicine (1979)

Presentation of CaseA 64-year-old woman was admitted to the hospital because of splenomegaly.She was well until six weeks earlier, when fever developed, accompanied by a dry cough and pleuritic pain in the left lower portion of the chest. A physician made a diagnosis of pleurisy, and erythromycin was given for one week, without improvement. Ampicillin was substituted but was discontinued after five days because of a generalized pruritic rash. The chest discomfort soon disappeared, but fever persisted, with a dry cough and weakness. Twelve days before admission she entered another hospital, where examination revealed that she was febrile . . .