tbuckley/cabot-search huggingface dataset:
Supplemental Feedings for High-Risk Preterm Infants
Authors: Hope K. Lima, Ronald S. Cohen, Thomas E. Young
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
연구논문 : 만성 B형간질환 환자의 라미부딘 내성 예측인자
Authors: 허정 ( Jeong Heo ), 조몽 ( Mong Cho ), 조병만 ( Byung Mann Cho ), 이선미 ( Sun Mi Lee ), 김태오 ( Tae Oh Kim ), 김광하 ( Gwang Ha Kim ), 강대환 ( Dae Hwan Kang ), 송근암 ( Geun Am Song )
Journal: Clinical and Molecular Hepatology (2007)
Ana o 3-specific IgE is a good predictor for clinically relevant cashew allergy in children
Authors: L. Lange, L. Lasota, A. Finger, D. Vlajnic, S. Büsing, J. Meister, I. Broekaert, C. Pfannenstiel, F. Friedrichs, M. Price, V. Trendelenburg, B. Niggemann, K. Beyer
Journal: Allergy (2016)

Introduction Component-resolved diagnostics using specific IgE to 2 S albumins has shown to be a valuable new option in diagnostic procedure. Ana o 3 is a 2 S albumin from cashew. The aim of this study was to investigate the role of Ana o 3-specific serum IgE in the diagnosis of cashew allergy and to identify cut-off levels to replace oral food challenges. Moreover, the value of additional determination of total IgE has been investigated. Methods In a multicentre study, we analysed specific IgE to cashew extract and Ana o 3 as well as total IgE in children with suspected cashew allergy using the ImmunoCAP-FEIA and a standardized diagnostic procedure including oral challenges where indicated. Results A total of 61 patients were included in the study. Forty-two were allergic to cashew, and 19 were tolerant. In receiver operating curves, Ana o 3 discriminates between allergic and tolerant children better than cashew-specific IgE with an area under the curve of 0.94 vs 0.78. The ratio of Ana o 3-specific IgE to total IgE did not further improve the diagnostic procedure. Probability curves for Ana o 3-specific IgE have been calculated, and a 95% probability could be estimated at 2.0 kU/l. Conclusion Specific IgE to Ana o 3 is a valuable tool for the diagnosis of cashew allergy. Considering its positive predictive value, it might allow to make a considerable number of oral challenges superfluous.
Profiling nitric oxide metabolites in patients with idiopathic pulmonary arterial hypertension
Authors: Rui Zhang, Xiao-Jian Wang, Hong-Da Zhang, Xiao-Qing Sun, Qin-Hua Zhao, Lan Wang, Jing He, Xin Jiang, Jin-Ming Liu, Zhi-Cheng Jing
Journal: European Respiratory Journal (2016)

Intact nitric oxide (NO) signalling is critical to maintaining appropriate pulmonary vascular tone. NO bioavailability is reduced in patients with pulmonary arterial hypertension. This study aimed to examine the impact of NO plasma metabolites (NOx) relative to haemodynamic dysfunction and mortality in patients with idiopathic pulmonary arterial hypertension (IPAH). A total of 104 consecutive adult IPAH patients who had undergone genetic counselling when first diagnosed were enrolled in this prospective study. The median concentration of NOx (μmol·L −1 ) was significantly lower in IPAH patients compared with healthy subjects, and was decreased further in 19 carriers of the bone morphogenetic protein-receptor type-2 ( BMPR2 ) mutation compared to non-carriers. Reduced concentrations of NOx were correlated with mean pulmonary arterial pressure (mPAP), pulmonary vascular resistance (PVR) and cardiac output. Compared with higher baseline NOx concentrations, patients with a NOx concentration of ≤10 μmol·L −1 had a markedly worse survival. After adjustment for clinical features, a BMPR2 mutation and haemodynamics, a lower NOx level remained an increased risk of mortality. Patients with IPAH had lower levels of plasma NOx, which correlated inversely with mPAP, PVR and survival. Plasma NOx may be an important biomarker and prognostic indicator, suggesting that reduced NO synthesis contributes to the pathogenesis of IPAH.
Hepatocyte Specific Expression of a Dominant Stable Form of B-Catenin Results in Early Lethality Due to Disturbances in Lipid and Glucose Metabolism
Authors: U. Lemberger, C. Fuchs, M. Karer, T. Stojakovic, S. Meier, C. Schöfer, G. Egger, F. Wrba, C. Gerner, M. Taketo, M. Trauner, C.H. Oesterreicher
Journal: Journal of Hepatology (2016)
Community mental health care worldwide: current status and further developments
Authors: Graham Thornicroft, Tanya Deb, Claire Henderson
Journal: World Psychiatry (2016)

This paper aims to give an overview of the key issues facing those who are in a position to influence the planning and provision of mental health systems, and who need to address questions of which staff, services and sectors to invest in, and for which patients. The paper considers in turn: a) definitions of community mental health care; b) a conceptual framework to use when evaluating the need for hospital and community mental health care; c) the potential for wider platforms, outside the health service, for mental health improvement, including schools and the workplace; d) data on how far community mental health services have been developed across different regions of the world; e) the need to develop in more detail models of community mental health services for low‐ and middle‐income countries which are directly based upon evidence for those countries; f) how to incorporate mental health practice within integrated models to identify and treat people with comorbid long‐term conditions; g) possible adverse effects of deinstitutionalization. We then present a series of ten recommendations for the future strengthening of health systems to support and treat people with mental illness.
A Rapid Bedside Screen to Predict Unplanned Hospitalization and Death in Outpatients with Cirrhosis: A Prospective Study of the Clinical Frailty Scale
Authors: P. Tandon, N. Tangri, L. Thomas, L. Zenith, T. Shaikh, M. Carbonneau, M. Ma, S. Jayakumar, K. Burak, A. Brisebois, J.G. Abraldes, T. Ferguson, S.R. Majumdar
Journal: Journal of Hepatology (2016)
Evaluation of two immunohistochemical assays for PD-L1 expression.
Authors: Steven M. Anderson, Lei Zhang, Lisa Brailey
Journal: Journal of Clinical Oncology (2016)

e23220 Background: Antibody based therapies to the PD-1/PD-L1 checkpoint blockade have shown great promise in the treatment of a variety of cancers. PD-L1 over-expression in tumor cells is one pathway for cancers to evade response of the immune system. Currently, there are several IHC assays that have been developed and linked with specific therapies involving PD-1 or PD-L1. These assays have significant differences in antibody clone, assay platforms, scoring criteria and assay cut-offs. In this study we have compared the results of two commercially available assays using the anti-PD-L1 28-8 rabbit antibody in the Dako assay and the SP263 rabbit antibody on the Ventana platform. Methods: We evaluated over 100 lung cancer samples, including predominately adenocarcinomas and squamous cell cancers. We used the scoring and interpretation criteria that had been established for the evaluation of NSCLC samples ( > 1% of tumor cells positive for the Dako assay and > 25% tumor cells positive with the Ventana assay). Results: For the set of cancer specimens evaluated the percentage of PD-L1 positive samples was 34.3% with the Dako assay and 19.3% with the SP263 antibody. The overall concordance between assays was 90.3%, but only 66.7% for specimens considered positive for PD-L1 expression. For adenocarcioma samples, 36.0% were positive with the Dako assay and 20.5% on the Ventana platform. These findings are consistent with other studies utilizing these assay formats. There was considerable variation in percentage of tumor cells staining positive as determined by the two methods, which along with the different assay cut-offs contributed to discordant results. We also evaluated a broad spectrum of non-neoplastic tissues and tissues such as tonsil and placenta stained positive with both assay formats Conclusions: This study, as well as others that have compared methods for PD-L1 expression, point to the importance of methodological and interpretation variation as well as other considerations such as tumor heterogeneity and dynamics of expression, when evaluating the use of PD-L1 as a biomarker of potential therapeutic response to checkpoint blockade inhibitors.
Acute Coronary Syndrome Patients Benefit from Platelet Glycoprotein IIb/IIIa Inhibition as Part of an Initially Medical Treatment Strategy: Results of a Meta-Analysis of Phase III Randomized Trials
Authors: E Boersma, RA Harrington, Frans Van de Werf, PW Armstrong, J Simes, Hasselblad, ML Simoons
Journal: Circulation (2001)
Patient-Reported Outcomes in Myelofibrosis Patients Help to Identify Patients' Needs
Authors: Tatyana Ionova, Tatyana Nikitina, Elza Lomaia, Alexandr Myasnikov, Tatyana Pospelova, Andrey Evseev, Taras Gritsenko, Anna Lyamkina, Elena Machulaytene, Elena Usacheva, Anna Rodionova, Kira Kurbatova
Journal: Blood (2015)
iAMP21 Is Associated with Inferior Outcomes in Children with Acute Lymphoblastic Leukemia (ALL) on Contemporary Children's Oncology Group (COG) Studies
Authors: Nyla A. Heerema, Elizabeth A. Raetz, Andrew J. Carroll, Michael J. Borowitz, Meenakshi Devidas, Julie M. Gastier-Foster, Eric C. Larsen, Mignon L Loh, Leonard A. Mattano, Kelly W. Maloney, Cheryl L Willman, Brent L. Wood, Naomi Winick, Stephen P. Hunger, William L. Carroll
Journal: Blood (2011)
The Consult Guys - Risk With Atrial Fibrillation: A Guy Thing?
Authors: Geno J. Merli, Howard H. Weitz
Journal: Annals of Internal Medicine (2016)

Web Exclusives20 September 2016The Consult Guys - Risk With Atrial Fibrillation: A Guy Thing?FREEGeno J. Merli, MD and Howard H. Weitz, MDGeno J. Merli, MDSearch for more papers by this author and Howard H. Weitz, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/W16-0009 SectionsSupplemental MaterialAboutVisual Abstract ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail The Consult Guys bring a new perspective to the art and science of medicine with lively discussion and analysis of real-world cases and situations.For more videos from and information on The Consult Guys, visit www.annals.org/ConsultGuys. Comments0 CommentsSign In to Submit A Comment Author, Article, and Disclosure InformationAffiliations: Disclosures: Geno J. Merli, MD, reports the following: Research grants/contracts: Bristol-Myers Squibb, Janssen, Portola; Consultancies: Bristol-Myers Squibb, Janssen. Howard H. Weitz, MD, reports that he has no financial relationships or interests to disclose. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 September 2016Volume 165, Issue 6Page: CG1KeywordsAtrial fibrillationDisclosureResearch grantsResearch reporting guidelines ePublished: 20 September 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.Loading ...
HCV–Related Mixed Cryoglobulinemia: Data from Piter, a Nationwide Italian HCV Cohort Study
Authors: L. Kondili, L.E. Weimer, A. Mallano, L. Fucili, M. Massella, M. Vinci, G. Borgia, M. Brunetto, L. Surace, G.B. Gaeta, L. Chemello, P. Andreone, G. Raimondo, R. Filomia, M. Persico, M. Puoti, M.G. Rumi, A. Benedetti, S. Fargion, D. Ieluzzi, G. Nardone, F. Giuseppe, A. Ciancio, G. Taliani, E. Biliotti, S. Madonia, B. Stagno, A. Alberti, M. Massari, F. Rosina, G. Mazzella, A. Di Leo, A. Iannone, C. Ferrari, A. Orlandini, M. Monti, T.A. Santantonio, L. Chessa, E.M. Erne, C. Coppola, M. Andreoni, F. Baldelli, M. Mondelli, P. Blanc, A. Gasbarrini, G. Verucchi, M. Colombo, M. Borghi, A. Craxì, S. Petta, E. Villa, O. Patti, F.P. Russo, M. Strazzabosco, S. Vella, A.L. Zignego
Journal: Journal of Hepatology (2016)
P38 MAPK Activity in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction in Vivo
Authors: Jin He, Zhiqiang Liu, Yuhuan Zheng, Jianfei Qian, Haiyan Li, Yong Lu, Jingda Xu, Bangxing Hong, Mingjun Zhang, Pei Lin, Zhen Cai, Robert Z. Orlowski, Larry W Kwak, Qing Yi, Jing Yang
Journal: Blood (2012)
Assessment of children's nutritional attitudes before oral food challenges to identify patients at risk of food reintroduction failure: a prospective study
Authors: L. Polloni, E. Ferruzza, L. Ronconi, A. Toniolo, F. Lazzarotto, R. Bonaguro, N. Celegato, A. Muraro
Journal: Allergy (2016)

Inappropriate dietary eliminations may impair quality of life, affect children's growth and unnecessarily impact on healthcare costs. Previous retrospective studies reported that around 25% of children continue a food-avoidance diet despite a negative oral food challenge (OFC). A definite pattern has not been found yet for patients not reintroducing the food. This study aimed to examine the role of child's nutritional attitudes and maternal anxiety in reintroducing food after a negative OFC.A prospective study was conducted involving 81 mothers of children with IgE-mediated food allergy. They completed a survey on nutritional behaviour and attitudes and the State-Trait Anxiety Inventory on the day of OFC and 6 months later.In total, 11.1% of children never or rarely ate the food after a negative OFC. Consumption of the reintroduced food is positively correlated to child's interest in tasting new foods before and after OFC and to changes in child's nutritional habits after OFC. It is negatively correlated to monotony of the diet after OFC. No correlations were found with other participants' characteristics or maternal anxiety. State anxiety significantly decreased after the OFC. A correlation was found between trait and state anxiety and the degree of change in nutritional habits after OFC.Evaluating child's approach towards food before the OFC is a promising approach to identify patients at risk of food reintroduction failure. Furthermore, it underlined the importance of reassessing food consumption in all patients after a negative OFC and supporting patients in the reintroduction of food.
O.03: Cost Effectiveness of Immune Checkpoint Inhibitors in Non-Small Cell Lung Cancer Relative to PD-L1 Expression
Authors: Pedro Aguiar, Ramon De Mello, Hakaru Tadokoro, Ilka Santoro, Hani Babiker, Kiran Avancha, Barbara Gutierres, Carmelia Barreto, Gilberto Lopes
Journal: Journal of Thoracic Oncology (2016)
GALNT14 Genotype Predicts Prognosis of Multiple Hepatogastrointestinal Cancers including Hepatocellular Carcinoma, Cholangiocarcinoma, Colorectal Cancer and Esophageal Cancer
Authors: C.-T. Yeh, K.-H. Liang, T.-S. Yeh, R.-C. Wu, C.-N. Yeh, W.-R. Lin, J.-M. Chian, Y.-K. Tsou
Journal: Journal of Hepatology (2016)
Portal Hemodynamics Predicts the Outcome in Severe Alcoholic Hepatitis Presenting as Acute-on-Chronic Liver Failure
Authors: A.K. Choudhury, M.K. Sharma, R. Maiwal, P. Jain, M.A. Mahtab, Y.K. Chawla, S.S. Tan, Q. Ning, H. Devarbhavi, D.N. Amarapurkar, C.W. Kim, S.S. Sadiq, A.S. Butt, C. Eapen, H. Ghazinyan, C. Yu, A. Sood, G.H. Lee, Z. Abbas, G. Shiha, L.A. Lesmana, D.A. Payawal, K.A. Dokmeci, G.K. Lau, S.K. Sarin
Journal: Journal of Hepatology (2016)
100% SVR4 with ABT-493 and ABT-530 with or without Ribavirin in Treatment-Naïve HCV Genotype 3-Infected Patients with Cirrhosis
Authors: P.Y. Kwo, D.L. Wyles, S. Wang, F. Poordad, E. Gane, B. Maliakkal, M.L. Shiffman, T.I. Ng, C.-W. Lin, R. Liu, J. Kort, F.J. Mensa
Journal: Journal of Hepatology (2016)
Dasatinib 140 Mg Once Daily (QD) Demonstrates Equivalent Efficacy and Improved Safety Compared with 70 Mg Twice Daily (BID) in Patients with Accelerated Phase Chronic Myeloid Leukemia (CML-AP): 2-Year Follow-up Data from CA180-035
Authors: Hagop M. Kantarjian, Dong-Wook Kim, Pedro Dorlhiac-Llacer, Ricardo Pasquini, Nina Khoroshko, John F. DiPersio, Martin C Müller, M. Brigid Bradley-Garelik, Chao Zhu, Martin S. Tallman
Journal: Blood (2008)
Adenovirus-mediated transfer of soluble guanylayte cyclase alpha 1 and beta 1 subunits increases nitric oxide responsiveness and reduces neointima formation in balloon-injured rat carotid arteries
Authors: Peter Sinnaeve, JD Chiche, ZX Nong, O Varenne, N Van Pelt, RD Gerard, Desire Collen, K Bloch, Stefan Janssens
Journal: Circulation (1998)
Retreatment of Patients who Failed Daa-Combination Therapies: Real-World Experience from a Large Hepatitis C Resistance Database
Authors: J. Vermehren, S. Susser, J. Dietz, T. von Hahn, J. Petersen, H. Hinrichsen, U. Spengler, S. Mauss, C. Berg, S. Zeuzem, C. Sarrazin
Journal: Journal of Hepatology (2016)
A Diet Combining High Fat and Glucose-Fructose Syrup Induces Obesity, Non-Alcoholic Steatohepatitis and Portal Hypertension in a New Animal Model
Authors: T. García-Lezana, M. Martell, N. Ezkurdia, M. Torres-Arauz, M.T. Salcedo, J. Genescà, S. Augustin
Journal: Journal of Hepatology (2016)
Surveillance results of patients with stage I nonseminomatous testis cancer.
Authors: S. Keskin, M. Ekenel, M. Başaran, T. Esen, F. Özcan, M. Tunç, S. E. Bavbek
Journal: Journal of Clinical Oncology (2010)

e15135 Background: The optimal management of stage I nonseminomatous testis cancer varies according to the centers' expertise. Available treatment strategies include close surveillance, retroperitoneal lymph node dissection, and chemotherapy with identical cure rates. We reviewed the data of stage I nonseminoma patients treated in our institution where surveillance is the routine approach. Methods: Retrospective analysis of 70 patients who were managed with a surveillance strategy in our institute since 2002 were studied. Patients underwent monthly radiographic and biochemical examinations in the first year, bimonthly examinations in the second year, every 3 months examinations in the third year, every 4 months examinations in the fourth year, semi-annually in the fifth year and yearly there after. CT/MRI scans of abdomen was obtained every 2 months in the first year, and then scheduled every 3-4 months for the second and third year, every 6 months in the fifth year and then at yearly intervals. Results: The median age was 26 years (16-67 y) and median follow up was 17 months (1-76 mo). Embryonal, endodermal sinus, mature teratoma, immature teratoma, seminoma, and choriocarcinoma components were positive in 50 (71%), 37 (52%), 34 (48%), 27 (38%), 21 (30%), and 5 (7%) patients, respectively. Twelve (17%) patients developed relapse during follow-up. Three patients had relapse in the retroperitoneal lymph nodes. Five patients had marker relapse. Four patients had retroperitoneal lymph node metastases with marker elevation. Relapses occurred within one year in 10 (83%) patients. Other two patients relapsed between 24 and 48 months. In relapsed patients, embryonal component and lymphovascular invasion was seen in 11 and 6 patients, respectively. Eleven of 12 patients were treated with combination chemotherapy upon relapse and one patient underwent lymphadenectomy alone. Only two patients had lymphadenectomy after salvage chemotherapy. None of the patients received chemotherapy after lymphadenectomy. Progression free survival rate was 75%. Conclusions: The surveillance is a reliable strategy, even in high risk stage I nonseminomatous testis cancer. In compliant patients, recurrences can be detected early and treated successfully. No significant financial relationships to disclose.
Serological Biomarkers of Extracellular Matrix Remodeling Predict Transplant-Free Survival in Primary Sclerosing Cholangitis Patients
Authors: M.J. Nielsen, D. Thorburn, D.J. Leeming, J.R. Hov, B. Moum, F. Saffioti, O.H. Gilja, K.M. Boberg, G. Mazza, M. Pinzani, T.H. Karlsen, M.A. Karsdal, M. Vesterhus
Journal: Journal of Hepatology (2016)
T-Antigen Expression Causes Macrothrombocytopenia and Extensive Hemophagocytosis in Mice Lacking the Sialyltransferase ST3Gal-I Specifically in Megakaryocytes
Authors: Renata Grozovsky, Silvia Giannini, Haley Ramsey, Martha Sola-Visner, Karin M Hoffmeister
Journal: Blood (2014)
Alanine Aminotransferase Normalization during Entecavir Treatment and the Hepatocellular Carcinoma Risk in Hepatitis B Virus-Associated Cirrhosis
Authors: S.K. Shin, J.E. Yeon, O.S. Kwon, E.J. Kim, H.N. Lee, S.H. Kang, K.S. Byun, J.H. Kim, S.Y. Kwon, S.J. Suh, H.J. Yim, Y.S. Kim, J.H. Kim
Journal: Journal of Hepatology (2016)
Development of dosing recommendation of S-1 for patients with renal dysfunction by prospective pharmacokinetic study
Authors: Eisuke Booka, Chiyo K Imamura, Yasuo Hamamoto, Takuro Mizukami, Daisuke Gomi, Takashi Ichiyama, Hiroya Takeuchi, Narikazu Boku, Yusuke Tanigawara, Yuko Kitagawa
Journal: Annals of Oncology (2015)
Humanization of Atherapeutic Claudin-1-Specific Antibody to Cure Hepatitis C Virus Infection in Monotherapy
Authors: R.G. Tawar, C.C. Colpitis, L. Mailly, C. Thumann, F. Xiao, L. Heydmann, S.C. Durand, P. Pessaux, M.B. Zeisel, T.F. Baumert
Journal: Journal of Hepatology (2016)
Next Generation Sequencing (NGS) of TP53 Gene Allows to Identify a Very High Risk Group of Philadelphia Negative Acute Lymphoblastic Leukemia (ALL) Patients
Authors: Silvia Salmoiraghi, Greta Ubiali, Manuela Tosi, Barbara Peruta, Marie Lorena Guinea Montalvo, Elena Oldani, Cristina Boschini, Alexander Kohlmann, Sabina Chiaretti, Tamara Intermesoli, Renato Bassan, Orietta Spinelli, Alessandro Rambaldi
Journal: Blood (2014)
Perilipin 1 binds to aquaporin 7 in human adipocytes and controls its mobility via protein kinase A mediated phosphorylation
Authors: Jesper S. Hansen, Christian Krintel, Malin Hernebring, Tatu J.K. Haataja, Sofia de Marè, Sebastian Wasserstrom, Urszula Kosinska-Eriksson, Madelene Palmgren, Cecilia Holm, Karin G. Stenkula, Helena A. Jones, Karin Lindkvist-Petersson
Journal: Metabolism (2016)

Accumulating evidence suggests that dysregulated glycerol metabolism contributes to the pathophysiology of obesity and type 2 diabetes. Glycerol efflux from adipocytes is regulated by the aquaglyceroporin AQP7, which is translocated upon hormone stimulation. Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation. Together, these findings are indicative of how glycerol release is controlled in adipocytes, and may pave the way for the future design of drugs against human metabolic pathologies.
TGF-β Is Selectively Expressed on Lymphoma B Cells and Regulates the Differentiation of Intratumoral T Cells in B-Cell Non-Hodgkin Lymphoma (NHL)
Authors: Zhi-Zhang Yang, Deanna Grote, Steven C. Ziesmer, Thomas E. Witzig, Anne J. Novak, Stephen M. Ansell
Journal: Blood (2011)