tbuckley/cabot-search huggingface dataset:
Interleukin-2 therapy of human cancer: potential benefits versus toxicity.
Authors: R B Herberman
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.1.1 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2783337 Interleukin-2 therapy of human cancer: potential benefits versus toxicity. R B HerbermanxR B HerbermanSearch for articles by this author Show More Pittsburgh Cancer Institute. https://doi.org/10.1200/JCO.1989.7.1.1 First Page PDF © 1989 by American Society of Clinical Oncology
Older Drivers and Cognitive Impairment
Authors: H. J. Chang, A. E. Burke, R. M. Glass
Journal: JAMA (2010)

ognitive impairment is defined as decline in at least one of the following areas: short-term memory, attention, orientation, judgment and problem-solving skills, and visualspatial skills.Changes in any of these areas could affect a person' s ability to drive any motor vehicle, including cars, golf carts, and lawn mowers.About 4% of current drivers over 75 years old have dementia (multiple cognitive deficits including memory impairment).The April 28, 2010, issue of JAMA includes an article about older drivers with cognitive impairment.
A community study of formal pastoral counseling activities of the clergy
Authors: R F Mollica, F J Streets, J Boscarino, F C Redlich
Journal: American Journal of Psychiatry (1986)

Although the clergy have been identified as a major community mental health resource, few epidemiologic studies of clergy practices have been conducted. The authors report a comprehensive survey of the counseling activities of clergy groups serving south-central Connecticut. They found that the clergy were a heterogeneous counseling group and that the counseling activities of many were extremely limited, although all were experienced with "troubled individuals". In recent years pastoral counselors have separated from their parishes and emerged as a psychotherapy profession. In contrast, certain parish-based clergy, especially the black clergy, have functioned as a major mental health resource to communities with limited access to professional mental health care.
A starlike Pattern Observed in Cervical Mucus Smears Obtained From Patients With Breast Cancer and Endocrine Disorders
Authors: Jacqueline I. Borelli, James B. Ward, Sara H. DeWitt, Pasco R. del Vecchio, Richard A. Malmgren
Journal: JNCI Journal of the National Cancer Institute (1960)

Microscopic examination of argyrophil secretion smears from the cervical and vaginal mucus of 77 breast-cancer patients and 237 patients with illnesses other than breast cancer revealed that a starlike pattern occurs 4 times more frequently in the breast-cancer group. The percentage of occurrence of the starlike pattern was 45.2 in the breast-cancer group and 11 in the group without breast cancer. Endocrine abnormalities appeared to be associated with the occurrence of the starlike pattern.
Health Utility Scores for People With Type 2 Diabetes in U.S. Managed Care Health Plans
Authors: Ping Zhang, Morton B. Brown, Dori Bilik, Ronald T. Ackermann, Rui Li, William H. Herman
Journal: Diabetes Care (2012)

To estimate the health utility scores associated with type 2 diabetes, its treatments, complications, and comorbidities.We analyzed health-related quality-of-life data, collected at baseline during Translating Research Into Action for Diabetes, a multicenter, prospective, observational study of diabetes care in managed care, for 7,327 individuals with type 2 diabetes. We measured quality-of-life using the EuroQol (EQ)-5D, a standardized instrument for which 1.00 indicates perfect health. We used multivariable regression to estimate the independent impact of demographic characteristics, diabetes treatments, complications, and comorbidities on health-related quality-of-life.The mean EQ-5D-derived health utility score for those individuals with diabetes was 0.80. The modeled utility score for a nonobese, non-insulin-treated, non-Asian, non-Hispanic man with type 2 diabetes, with an annual household income of more than $40,000, and with no diabetes complications, risk factors for cardiovascular disease, or comorbidities, was 0.92. Being a woman, being obese, smoking, and having a lower household income were associated with lower utility scores. Arranging complications from least to most severe according to the reduction in health utility scores resulted in the following order: peripheral vascular disease, other heart diseases, transient ischemic attack, cerebral vascular accident, nonpainful diabetic neuropathy, congestive heart failure, dialysis, hemiplegia, painful neuropathy, and amputation.Major diabetes complications and comorbidities are associated with decreased health-related quality-of-life. Utility estimates from our study can be used to assess the impact of diabetes on quality-of-life and conduct cost-utility analyses.
PWE-004 An audit of inpatient bowel preparation for colonoscopy
Authors: KA Knight, U Ashfaq, C Creagh-Barry, H Rooney, A Macdonald, M Dick
Journal: Gut (2015)

<h3>Introduction</h3> Colonoscopy in the elderly and co-morbid is not without risk. Clinicians may feel that bowel preparation as an inpatient in this patient population may be safer and more effective. However, to the best of our knowledge the rationale, efficacy and complication rate of inpatient colonoscopy has not been documented. We present the results of a pilot study looking at inpatient bowel preparation for facilitating colonoscopy. <h3>Method</h3> A retrospective case note review of all patients admitted for inpatient bowel preparation prior to colonoscopy over a 12 month period at one district general hospital was performed. Additional information was extracted from established databases (Unisoft, Track Care and Endoscopy Suite registers). Data collected included patients’ demographics, past medical history, reason for inpatient preparation, type of ward the preparation was carried out in and type of bowel preparation used. <h3>Results</h3> Between January and December 2014, 63 patients (median age - 72 years) underwent 73 attempts at inpatient colonoscopy. (During the same time period, 2,458 outpatient colonoscopies were performed: inpatients = 2.5% of total). 47 patients underwent colonoscopy following emergency admission. Indications included anaemia (44%), PR bleeding (19%) and altered bowel habit (15%). Overall, 34% (n = 21) of inpatient colonoscopies were incomplete. Failure was attributed to inadequate bowel preparation in 27% (n = 17). Bowel preparation failed in 18% of females and 8% of males. Where bowel preparation was considered inadequate, the referring ward was medical (32%) and surgical (11%). Additionally, where bowel preparation failed, Moviprep had been prescribed in 18%, Kleenprep in 7%, Picolax in 5% and Fleet in 4%. Only 5% had a successful inpatient colonoscopy when previous outpatient preparation had failed. Only 3 of 10 patients having a second attempt at inpatient colonoscopy were successful. Of the original 63 patients who underwent this inpatient examination, only 6 were diagnosed with cancer (one patient went on to elective surgery). The “all cause” 30-day mortality following inpatient colonoscopy was 6.3%. <h3>Conclusion</h3> Although this is a small cohort, the initial results are worrying. Inpatient colonoscopy often fails and the number diagnosed with significant pathology which is amenable to treatment is small. There is also a very real 30-day mortality rate which may have been contributed to by this invasive procedure. While our initial findings may be peculiar to our own unit where we have high levels of co-morbidity, this pilot suggests that further work is required nationally to clarify the indications/risks/results in this small but problematic patient group. <h3>Disclosure of interest</h3> None Declared.
Host and Extraneous Factors in Heterologous Tumor Transplantation&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: E. J. Eichwald, M. D., H. Chan, M. D., M. Landa, M. D., R. G. Evans, B. A.
Journal: JNCI Journal of the National Cancer Institute (1950)

Host and Extraneous Factors in Heterologous Tumor Transplantation Get access E. J. Eichwald, M. D., E. J. Eichwald, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Chan, M. D., H. Chan, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Landa, M. D., M. Landa, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. G. Evans, B. A. R. G. Evans, B. A. Department of Pathology, Veterans' Administration Hospital, and University of Utah Medical School, Salt Lake City, Utah; and the Department of Pathology, The Children's Hospital, and Harvard Medical School, Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 1, August 1950, Pages 17–31, https://doi.org/10.1093/jnci/11.1.17 Published: 01 August 1950 Article history Received: 17 March 1950 Published: 01 August 1950
Diabetic Neuropathy
Authors: Aria A. Razmaria
Journal: JAMA (2015)

About half of all people with diabetes have some form of neuropathy. What Is Diabetic Neuropathy?Diabetic neuropathy is a group of nerve disorders that can cause numbness and pain.Various nerves in the body can be involved, including in the feet, legs, arms, and internal organs like the heart, digestive system, and sex organs.An individual nerve can be involved, but more commonly, a pattern of neuropathy affecting many nerves and different locations (polyneuropathy) occurs.The risk of developing neuropathy increases the longer a person has diabetes.High blood glucose and lipid levels, impaired blood supply to the nerves, obesity, high blood pressure, smoking, and alcohol use all contribute to the development of diabetic neuropathy.Some people have an inherited susceptibility and are more prone to diabetic neuropathy.An article in the November 24, 2015, issue of JAMA reviews the diagnosis and treatment of distal symmetric polyneuropathy.
Immunogenic Properties of a Soluble Tumor-Specific Transplantation Antigen Induced by Simian Virus 40
Authors: Mark S. Drapkin, Ettore Appella, Lloyd W. Law
Journal: JNCI Journal of the National Cancer Institute (1974)

Soluble tumor-specific transplantation antigen was obtained from dissociated tumor cells of the ascites or tissue-cultured BALB/c lines (mKSA) transformed by simian virus 40. Immunogenic activity as assayed by tumor rejection was clearly recovered in 50% yield in the crude membrane preparation and in at least 5% yield in the crude soluble preparation. This activity was specific. After chromatography on Sephadex G-150, this activity was preserved. Contrary to other studies, we were unable to use in vitro assays of cytotoxicity to monitor solubilization and purification of this antigen.
Transplantation Studies on an Induced Fibrosarcoma in Rats. II. Influence of Sex Hormones and Repeated Transplantation on Tumor Immunity&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/xref&gt;
Authors: Michael Klein
Journal: JNCI Journal of the National Cancer Institute (1950)

Transplantation Studies on an Induced Fibrosarcoma in Rats. II. Influence of Sex Hormones and Repeated Transplantation on Tumor Immunity Get access Michael Klein Michael Klein research fellow National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 2, October 1950, Pages 381–389, https://doi.org/10.1093/jnci/11.2.381 Published: 01 October 1950 Article history Received: 08 August 1950 Published: 01 October 1950
PTH-101 The role of tissue factor pathway inhibitor (tfpi) in liver injury
Authors: G Petts, H Kudo, A Dorling, M Thursz, R Goldin
Journal: Gut (2015)

<h3>Introduction</h3> Studies have demonstrated that pro-coagulant states are associated with rapidly advancing liver fibrosis and that anticoagulation limits this. In acute liver injury studies have suggested that decreased coagulation cascade activation results in reduced acute liver injury. TFPI is a serine protease inhibitor that acts as a homeostatic brake in the coagulation cascade. TFPI is a potential target for the inhibition of the coagulation cascade to modify liver disease. To further investigate this, transgenic mice expressing human TFPI were used in models of liver injury. The transgenic mice carry a genetic modification that allows cells expressing alpha smooth muscle actin (αSMA) to simultaneously express TFPI. This results in cells, such as activated hepatic stellate cells, expressing TFPI in a manner not seen in wild type mice. <h3>Method</h3> Transgenic and wild type mice were used in a chronic liver injury model (carbon tetrachloride, CCl<sub>4</sub>) or an acute liver injury model (paracetamol) and culled at set time points after dosing. <h3>Results</h3> <b><i>Chronic liver injury: </i></b>At 24 h after the last dose of CCl<sub>4</sub>there was a significant decrease in αSMA expression in the transgenic mice compared to wild type (Mann-Whitney test, p = 0.003). At 24 h there was also a decrease in tissue inhibitor of metalloproteinase (TIMP) -1 gene expression but normal matrix metalloproteinase (MMP) -2 and -9 gene expression. This suggested a microenvironment that would promote fibrosis resolution through decreased hepatic stellate activation and loss of inhibition of MMPs. However after 24 h this difference was lost. At 24 h after the last dose of CCl<sub>4</sub>and at all subsequent time points there was no significant difference between fibrosis in transgenic and wild type mice as demonstrated by Sirius red staining, hydroxyproline assay and collagen 1α1 gene expression. <b><i>Acute liver injury: </i></b>In early paracetamol induced liver injury (2–12 h post-dose) there was no significant difference in parenchymal necrosis in transgenic compared to wild type mice. However, at 24 h and 48 h after dosing there was a significant decrease in parenchymal necrosis in transgenic compared to wild type mice (24 h: mean percentage necrosis 6% vs. 30% respectively, Mann-Whitney test p = 0.008. 48 h: percentage necrosis 2% vs. 20% respectively, Mann-Whitney test p = 0.036). <h3>Conclusion</h3> These results suggest that TFPI is not a potential therapeutic target in chronic liver injury. However in acute paracetamol induced liver injury TFPI appears to reduce liver injury in a sustained manner from 24 h after the initial insult. This suggests a role for TFPI in managing acute liver injury and warrants further investigation. <h3>Disclosure of interest</h3> None Declared.
THU0140 Baseline Pain Level Significantly Predicts Fatigue in RA Patients with Low Disease Activity After Six Months Dmard Treatment
Authors: C.L. Olsen, E. Lie, H.A. Zangi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Fatigue is a frequently occurring multidimensional symptom in patients with RA and can be as difficult to cope with as pain. Fatigue affects every sphere of life and may cause major distress. The relationship between fatigue, disease activity and personal factors is still unclear. Some patients experience high levels of fatigue even if the treat-to-target goal of remission or low disease activity is achieved. Among disease-related factors pain and disability are found to be strongly associated with high levels of fatigue.<sup>1</sup> <h3>Objectives</h3> To explore possible relationships between demographic variables, disease-related factors, disability, and fatigue in a Norwegian cohort of RA patients who had achieved low disease activity or remission after six months DMARD-treatment. <h3>Methods</h3> A total of 2193 RA patients (age ≥18 years) starting either methotrexate (MTX) monotherapy as their first DMARD, or a TNF-inhibitor (TNFi) in combination with MTX as their first DMARD were retrieved from the Norwegian DMARD-register (NOR-DMARD). At 6-month follow-up 699 (32%) patients were in low disease activity (DAS28 2.6-3.2) or remission (DAS28 &lt;2.6). In this sample, bivariate and multivariate linear regression analyses were conducted with fatigue (Visual Analogue Scale; VAS, 0-100 mm) at 6 months as dependent variable. Age, gender, disease duration, and baseline ESR, 28 swollen and tender joint counts, pain (VAS, 0-100 mm) and disability (modified health assessment questionnaire; MHAQ) were tested as predictors of fatigue level at 6 months. Furthermore, we examined cross-sectional associations between fatigue and the respective variables at 6 months, and also between fatigue and treatment group (MTX mono or TNFi+MTX). <h3>Results</h3> At 6 months, the median (25, 75 perc.) level of fatigue was 20.0 (6.0, 43.0). By bivariate regression analyses female gender, number of tender joints, higher disability and higher pain at baseline significantly predicted higher fatigue at 6 months (all p-values &lt;0.001). In the multivariate analysis lower ESR and higher pain were statistically significant predictors (p&lt;0.001) of higher fatigue. By multivariate cross-sectional analysis at 6 months, lower age and higher pain were significantly associated with higher fatigue (p&lt;0.001). <h3>Conclusions</h3> Pain levels at baseline and 6 months were associated with higher level fatigue in patients achieving low disease activity with DMARD treatment. These results support the previously reported relationship between pain and fatigue in RA, and indicate that also patients in low disease activity may need non-pharmacological interventions in addition to the DMARD-treatment to manage their pain and fatigue. <h3>References</h3> Nikolaus S et al. Fatigue and Factors Related to Fatigue in Rheumatoid Arthritis: A Systematic Review. Arthritis Care Res 2013; 65(7): 1128-1146. <h3>Disclosure of Interest</h3> None declared
Outbreak with a novel avian influenza A(H7N9) virus in China - scenarios and triggers for assessing risks and planning responses in the European Union, May 2013
Authors: C Schenk, D Plachouras, N Danielsson, A Nicoll, E Robesyn, D Coulombier
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Thoracic Duct Malformations
Authors: OSCAR LUIS L??PEZ, EDUARDO RODR??GUEZ-MAISANO, JOS?? LUIS DELEVAUX
Journal: Clinical Nuclear Medicine (1986)

Log in or Register Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssuePrevious IssuesPublished Online First Collections ACNM MeetingsCMECommunication in OrganizationCOVID-19Feedback and RewardsFrom the American College of Nuclear MedicineHighly Cited and Frequently Read ArticlesPlanning and Conducting Meetings EffectivelyQuality and Safety in Health CareRecruitment of New PhysiciansTips for Giving a Memorable PresentationTips for LeadersTips for Physicians in Getting the Right Job ACNM ArticlesACNM Website For Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalEditorial BoardAdvertisingOpen AccessSubscription ServicesReprintsRights and Permissions All Articles Images Videos Podcasts Blogs Advanced Search
Application of Millipore Filtration Technique to Cytologic Material
Authors: P. R. Del Vecchio, S. H. DeWitt, J. I. Borelli, J. B. Ward, T. A. Wood, Jr., R. A. Malmgren
Journal: JNCI Journal of the National Cancer Institute (1959)

A millipore filtration technique for preparing fluid specimens for cytologic examination is described. This method was designed for simplicity and for recovery of the maximum number of cells from all specimens, regardless of volume or cell concentration. The morphology of the cells was well preserved.
Combined Modality Treatment with Intensified Chemotherapy and Dose-Reduced Involved Field Radiotherapy in Patients with Early Unfavourable Hodgkin Lymphoma (HL): Final Analysis of the German Hodgkin Study Group (GHSG) HD11 Trial.
Authors: Peter Borchmann, Volker Diehl, Helen Goergen, Horst Mueller, Rolf Peter Mueller, Hans T. Eich, Hans Konrad Mueller-Hermelink, Richard Herrmann, Jana Markova, Anthony D. Ho, Wolfgang Hiddemann, Bernd Doerken, Richard Greil, Andreas Engert
Journal: Blood (2009)
SP0145 Environmental and Lifestyle Predictors for the Development of Rheumatoid Arthritis
Authors: K. Costenbader
Journal: Annals of the Rheumatic Diseases (2015)

Genetic and environmental factors interact in the pathogenesis of autoimmune diseases, including RA. Epidemiologic research over the past few decades has identified several lifestyle and environmental factors that are related to increased risk of developing RA, including cigarette smoking, exposure to crystalline silica, obesity, and most recently dietary factors. I will review some recent research findings on the associations of each of these with risk of RA, and highlight known or suspected interactions with genetic factors. <h3>Disclosure of Interest</h3> None declared
SAT0376 Predictive Significance of CCL21 and CXCL13 Levels in the Minor Salivary Glands of Patients with SjÖgren's Syndrome
Authors: K.-E. Lee, J.-W. Lee, D.-J. Park, S.-S. Lee
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> Chemokines, which control inflammatory cell migration, have been shown to play important roles in the inflammatory processes associated with Sjögren9s Syndrome (SS). CCL21 and CXCL13 within the lymphocytic infiltrate characteristic of the condition have been reported to contribute to ectopic lymphoneogenesis. In the current study, we investigated whether the laboratory and clinical manifestations of SS patients were associated with CCL21 and CXCL13 expression levels in the minor salivary gland. <h3>Methods</h3> We obtained sociodemographic data on a total of 106 SS patients, documented glandular and extraglandular manifestations of the disease, performed minor salivary gland biopsies, and analyzed laboratory findings. EULAR index values of SS disease activity (ESSDAI values) at the time of biopsy, and SS disease damage index (SSDDI) values, were also noted. An immunohistochemical approach was used to (semiquantitatively) measure the expression levels of CCL21 and CXCL13 in the minor salivary glands. <h3>Results</h3> The minor salivary glands of SS patients stained positively for CCL21 and CXCL13 in 46.2% (49/106) and 70.7% (75/106) of all cases, respectively. Higher-level expression of CCL21 was associated with an elevated ESR, an increased IgG level, elevated anti-SS-A and -SS-B titers, a higher focus score, and a greater ESSDAI value at the time of biopsy. Higher-level expression of CXCL13 was associated with an elevated ESR, an increased IgG level, elevated anti-SS-A and -SS-B titers, a rise in the level of rheumatoid factor, a higher focus score, and a greater ESSDAI value at the time of biopsy. In patients with extraglandular manifestations of SS, the prevalence of lymphadenopathy tended to rise with an increase in the level of CCL21. <h3>Conclusions</h3> The expression levels of CCL21 and CXCL13 within the lymphocytic infiltrates of SS patients were associated with several laboratory features of the disease, lymphadenopathy, and the extent of clinical disease activity. CCL21 and CXCL13 levels should serve as useful markers predicting SS disease activity and prognosis. <h3>Disclosure of Interest</h3> None declared