tbuckley/cabot-search huggingface dataset:
Natriuretic Peptides as Well as Endothelin, and Not Troponin Are of Value in Early Diagnosis of Acute Cardiotoxicity in Children Undergoing Hematopoietic Stem Cell Transplantation
Authors: Agnieszka Zaucha-Prazmo, Katarzyna Drabko, Elzbieta Sadurska, Jerzy R Kowalczyk
Journal: Blood (2008)
TCT-398 Impact of scaffold oversizing, underexpansion and postdilatation on acute angiographic and one year clinical outcomes in patients with ACS treated with bioresorbable vascular scaffolds. A pooled analysis from BVS STEMI First and BVS EXPAND studies
Authors: Mariusz Tomaniak, Cordula Felix, Jiang Ming Fam, Robert-Jan van Geuns, Nicolas Van Mieghem, Evelyn Regar, Joost Daemen, Felix Zijlstra, Roberto Diletti
Journal: Journal of the American College of Cardiology (2016)
Abstract 12402: Noninvasive Evaluation of the Feature of Hypertensive Heart Failure With Preserved and Reduced Ejection Fraction using Three-dimensional Speckle Tracking Echocardiography With High Volume Rate
Authors: Shingo Minatoguchi, Masanori Kawasaki, Ryuhei Tanaka, Maki Saeki, Maki Nagaya, Noriaki Sato, Mayumi Kaneda, Reiko Matsuoka, Hirotaka Miwa, Takashi Yoshizane, Makoto Iwama, Takeshi Hirose, Koji Ono, Masazumi Arai, Toshiyuki Noda, Shinya Minatoguchi
Journal: Circulation (2015)

Background: Left ventricular (LV) systolic and diastolic property in hypertension (HTN) may be deteriorated by pressure overload that causes LV hypertrophy (LVH) and fibrosis, resulting in hypertensive heart failure (HHF). HHF with reduced ejection fraction (HFrEF) or preserved EF (HFpEF) is mainly caused by systolic dysfunction or diastolic dysfunction, respectively. Some of HHF have combined dysfunction and LV torsion may play an important role to maintain systolic performance even in HHF. Methods: We examined 31 controls (age 65±12), 94 HTN (age 69±11), 24 HFpEF (EF≧50%) (age 79±10) and 13 HFrEF (EF&lt;50%) (age 66±13) by one-beat real-time 3-dimensional speckle tracking echocardiography with volume rate of 70-80vps (3D-STE). LV radial strain rate at systole (SR-S) and torsion were assessed as an index that reflects LV contractility. Tau, SR at isovolumic relaxation (SR-IVR) and untorsion rate were assessed as relaxation. Pulmonary capillary wedge pressure (PCWP) was estimated as 10.8 - 12.4 x log {left atrial (LA) active emptying function / LA minimum volume} as we recently reported. Tau was calculated as IVR time / (ln 0.9 x systolic blood pressure - ln PCWP). LV stress was calculated as LV radius x pressure / thickness. LV stiffness was estimated as LV diastolic stress / strain. Results: LVEF in HFpEF was comparable to control and HTN, whereas LV SR-S and torsion were reduced associated with increased systolic stress. LVEF, SR-S and torsion were reduced in HFrEF compared to control. Tau and untorsion rate were deteriorated in HFrEF. LV SR-IVR was deteriorated in only HFpEF. LV stiffness in HFpEF and HFrEF were increased associated with increased diastolic stress (table). Conclusion: Noninvasive 3D-STE examination revealed that LVEF in HFrEF was decreased associated with decreased contractility and increased systolic stress and that LV diastolic function such as LV relaxation and stiffness in HFpEF was deteriorated associated with increased PCWP and diastolic stress.
TCT-219 Influence Of Anemia On Physician-Recommended DAPT Discontinuation After Percutaneous Coronary Intervention
Authors: Michela Faggioni, Jaya Chandrasekhar, Usman Baber, Birgit Vogel, David Moliterno, Timothy Henry, Philippe Gabriel Steg, Antonio Colombo, Charles Gibson, Stuart Pocock, Bernhard Witzenbichler, Alaide Chieffo, David Cohen, Giora Weisz, Annapoorna Kini, George Dangas, Mitchell Krucoff, Roxana Mehran
Journal: Journal of the American College of Cardiology (2016)
TCT-114 Comparing Hemodynamic Profiles and Outcomes in Cardiogenic Shock Requiring VA-ECMO or Impella for Circulatory Support
Authors: Michele Esposito, Sudeep Kuchibhotla, David Zisa, Ryan O'Kelly, Shiva Annamalai, Adel Ghuloom, Leslie Lussier, Catalina Breton, Robert Pedicini, Andrew Mullin, Carey Kimmelstiel, Michael Kiernan, Amanda Vest, Navin Kapur
Journal: Journal of the American College of Cardiology (2016)
PS01.70: Ceritinib Dosing Patterns and Outcomes of Patients with ALK+ NSCLC in a Real-World Practice in the United States
Authors: Edmond Bendaly, Anand Dalal, Kenneth Culver, Philip J. Galebach, Iryna Bocharova, Rebekah Foster, Gero Struebbe, Annie Guerin
Journal: Journal of Thoracic Oncology (2016)
Role of Troponins I and T and <i>N</i>-Terminal Prohormone of Brain Natriuretic Peptide in Monitoring Cardiac Safety of Patients With Early-Stage Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Receiving Trastuzumab: A Herceptin Adjuvant Study Cardiac Marker Substudy
Authors: Dimitrios Zardavas, Thomas M. Suter, Dirk J. Van Veldhuisen, Jutta Steinseifer, Johannes Noe, Sabine Lauer, Nedal Al-Sakaff, Martine J. Piccart-Gebhart, Evandro de Azambuja
Journal: Journal of Clinical Oncology (2017)

Purpose Women receiving trastuzumab with chemotherapy are at risk for trastuzumab-related cardiac dysfunction (TRCD). We explored the prognostic value of cardiac markers (troponins I and T, N-terminal prohormone of brain natriuretic peptide [NT-proBNP]) to predict baseline susceptibility to develop TRCD. We examined whether development of cardiac end points or significant left ventricular ejection fraction (LVEF) drop was associated with markers' increases. Patients and Methods Cardiac marker assessments were coupled with LVEF measurements at different time points for 533 patients from the Herceptin Adjuvant (HERA) study who agreed to participate in this study. Patients with missing marker assessments were excluded, resulting in 452 evaluable patients. A primary cardiac end point was defined as symptomatic congestive heart failure of New York Heart Association class III or IV, confirmed by a cardiologist, and a significant LVEF drop, or death of definite or probable cardiac causes. A secondary cardiac end point was defined as a confirmed significant asymptomatic or mildly symptomatic LVEF drop. Results Elevated baseline troponin I (> 40 ng/L) and T (> 14 ng/L), occurring in 56 of 412 (13.6%) and 101 of 407 (24.8%) patients, respectively, were associated with an increased significant LVEF drop risk (univariate analysis: hazard ratio, 4.52; P < .001 and hazard ratio, 3.57; P < .001, respectively). Few patients had their first elevated troponin value recorded during the study (six patients for troponin I and 25 patients for troponin T). Two patients developed a primary and 31 patients a secondary cardiac end point (recovery rate of 74%, 23 of 31). For NT-proBNP, higher increases from baseline were seen in patients with significant LVEF drop. Conclusion Elevated troponin I or T before trastuzumab is associated with increased risk for TRCD. A similar conclusion for NT-proBNP could not be drawn because of the lack of a well-established elevation threshold; however, higher increases from baseline were seen in patients with TRCD compared with patients without.
TCT-31 Impact of Strut Thickness on Short-Term Healing Response after Bioresorbable Scaffold Implantation: Serial OCT Evaluation of Novel Thin Strut Sirolimus Eluting BRS Versus Thick Strut Everolimus Eluting BRS in Porcine Coronary Arteries.
Authors: Pawel Gasior, Yanping Cheng, Jinggang Xia, Andres Valencia, Alex Estrada, Jenn McGregor, Kamal Ramzipoor, Chang Lee, Gerard Conditt, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2016)
TCT-771 Clinical and Hemodynamic Efficacy of Balloon Pulmonary Angioplasty for Inoperable Chronic Thromboembolic Pulmonary Hypertension: A Meta-Analysis
Authors: Arun Kanmanthareddy, alok saurav, Hemantha Koduri, JItendra Pandya, Abhilash Akinapelli, Aiman Smer, Muhammad Azzouz, Michael White, Anjali Vaidya, Scott Lilly
Journal: Journal of the American College of Cardiology (2016)
The neural basis of perceived intensity in natural and artificial touch
Authors: Emily L. Graczyk, Matthew A. Schiefer, Hannes P. Saal, Benoit P. Delhaye, Sliman J. Bensmaia, Dustin J. Tyler
Journal: Science Translational Medicine (2016)

Electrical connections between nerves and a prosthetic device enable amputees to discern precise, graded sensory intensity ranging from light touch to intense pressure.
TCT-93 Near-infrared spectroscopy derived Lipid Core Burden Index predicts major adverse cardiovascular events in patients with coronary artery disease during 4.3 year follow-up
Authors: Anne Sophie Schuurman, Isabella Kardys, Rohit Oemrawsingh, Roberto Diletti, Robert-Jan van Geuns, Nicolas Van Mieghem, Evelyn Regar, Patrick Serruys, K. Martijn Akkerhuis, Eric Boersma
Journal: Journal of the American College of Cardiology (2016)
Pulmonary fibrosis in the era of stratified medicine
Authors: Susan K Mathai, Chad A Newton, David A Schwartz, Christine Kim Garcia
Journal: Thorax (2016)

Both common and rare variants contribute to the genetic architecture of pulmonary fibrosis. Genome-wide association studies have identified common variants, or those with a minor allele frequency of &gt;5%, that are linked to pulmonary fibrosis. The most widely replicated variant (rs35705950) is located in the promoter region of the <i>MUC5B</i> gene and has been strongly associated with idiopathic pulmonary fibrosis (IPF) and familial interstitial pneumonia (FIP) across multiple different cohorts. However, many more common variants have been identified with disease risk and in aggregate account for approximately one-third of the risk of IPF. Moreover, several of these common variants appear to have prognostic potential. Next generation sequencing technologies have facilitated the identification of rare variants. Recent whole exome sequencing studies have linked pathogenic rare variants in multiple new genes to FIP. Compared with common variants, rare variants have lower population allele frequencies and higher effect sizes. Pulmonary fibrosis rare variants genes can be subdivided into two pathways: telomere maintenance and surfactant metabolism. Heterozygous rare variants in telomere-related genes co-segregate with adult-onset pulmonary fibrosis with incomplete penetrance, lead to reduced protein function, and are associated with short telomere lengths. Despite poor genotype-phenotype correlations, lung fibrosis associated with pathogenic rare variants in different telomere genes is progressive and displays similar survival characteristics. In contrast, many of the heterozygous rare variants in the surfactant genes predict a gain of toxic function from protein misfolding and increased endoplasmic reticulum (ER) stress. Evidence of both telomere shortening and increased ER stress have been found in sporadic IPF patients, suggesting that the mechanisms identified from rare variant genetic studies in unique individuals and families are applicable to a wider spectrum of patients. The ability to sequence large cohorts of individuals rapidly has the potential to further our understanding of the relative contributions of common and rare variants in the pathogenesis of pulmonary fibrosis. The UK 100,000 Genomes Project will provide opportunities to interrogate both common and rare variants and to investigate how these biological signals provide diagnostic and prognostic information in the era of stratified medicine.
Molecular Chaperone HSP90 Is Necessary to Prevent Cellular Senescence via Lysosomal Degradation of p14ARF
Authors: Su Yeon Han, Aram Ko, Haruhisa Kitano, Chel Hun Choi, Min-Sik Lee, Jinho Seo, Junya Fukuoka, Soo-Youl Kim, Stephen M. Hewitt, Joon-Yong Chung, Jaewhan Song
Journal: Cancer Research (2016)

The tumor suppressor function of p14ARF is regulated at a posttranslational level via mechanisms yet to be fully understood. Here, we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase C-terminus of HSP70-interacting protein (CHIP). The ternary complex of HSP90, CHIP, and p14ARF was required to induce the lysosomal degradation of p14ARF by an ubiquitination-independent but LAMP2A-dependent mechanism. Depletion of HSP90 or CHIP induced p14ARF-dependent senescence in human fibroblasts. Premature senescence observed in cells genetically deficient in CHIP was rescued in cells that were doubly deficient in CHIP and p14ARF. Notably, non-small cell lung cancer cells (NSCLC) positive for p14ARF were sensitive to treatment with the HSP90 inhibitor geldanamycin. Furthermore, overexpression of HSP90 and CHIP with a concomitant loss of p14ARF correlated with poor prognosis in patients with NSCLC. Our findings identify a relationship between p14ARF and its chaperones that suggest new therapeutic strategies in cancers that overexpress HSP90. Cancer Res; 77(2); 343-54. ©2016 AACR.
Evaluation of p53 and BCL2 expression, mutation, and aneuploidy status on treatment response in an Indian cohort of primary Ca larynx
Authors: R. Sahoo, V. Babu, G. Patil, J. Kulkarni, S. Rao, S. Thakur, G. Dondhalay, A. Banerjee, A. Kumar BS, A. Korlimarla, R. Rao M
Journal: Journal of Clinical Oncology (2009)

e17057 Background: Organ-sparing therapy consisting of cisplatin and 5-fluorouracil, combined with radiation for advanced head and neck squamous cell carcinoma (HNSCC) have been advocated in Ca larynx patients. However, failure of some tumors to respond to treatment or tumor recurrence limits the overall success of these therapies. P53 mutations have been linked to cisplatin resistance in other solid tumors. In this study we evaluate the relationships between P53 overexpression/mutations, BCL2 expression and ploidy status on treatment response in retrospective cohort of Ca Larynx patients. Methods: Samples from 18 patients with histopathologically confirmed Ca Larynx were analysed from our biorepository after consent. Clinical, sociodemographic information and response to treatment were abstracted from case records. P53 and BCL2 over expression were checked by IHC and p53 mutation by PCR and direct sequencing. DNA ploidy and S-phase fractions were also analysed. Bivariate relationships were determined between these variables using Spearmans rank correlation. Independent samples t tests were used to determine changes in P53 over expression, BCL2 expression Ploidy status and S phase fractions in both responders and non responders. Results: There was a trend for increase in P53 over expression and BCL2 expression and decrease in S phase fractions in responders vs non responders. Neither p53 over expression (75% of cases) and BCL 2 over expression (17% of cases) correlated significantly with treatment response. However, BCL2 expression correlated negatively with disease stage (r = - 0.57, p = 0.02). Aneuploidy was observed in node positive tumors (p = 0.04). Conclusions: The results suggest poor association of molecular markers with treatment response and should not be relied as a marker for treatment response. Though there is a trend for association a larger sample size is required to demonstrate the findings. No significant financial relationships to disclose.
Cost-effectiveness of anticoagulants for suspected heparin-induced thrombocytopenia in the United States
Authors: Ahmed Aljabri, Yvonne Huckleberry, Jason H. Karnes, Mahdi Gharaibeh, Hussam I. Kutbi, Yuval Raz, Seongseok Yun, Ivo Abraham, Brian Erstad
Journal: Blood (2016)
Identification Of Patients At High Risk Of Chronic Graft-Versus-Host Disease: Gvhd Prophylaxis
Authors: Gabriel Afram, Jose Antonio Pérez Simón, Mats Remberger, Teresa Caballero-Velázquez, Rodrigo Martino, Jose Luis Piñana, Olle Ringden, Albert Esquirol, Dolores Caballero, Irene Garcia, Lucía López-Corral, Jordi Sierra, Oriana López-Godino, Per T. Ljungman, Jesus F San Miguel, Hans Hagglund
Journal: Blood (2013)
PERFIL DE SEGURIDAD Y RENDIMIENTO DIAGNÓSTICO DE LA USE-PAAF DEL CONDUCTO DE WIRSUNG DILATADO (CWD)
Authors: C Sánchez-Montes, VJ Morales, G Fernández-Esparrach, IK Araujo, O Sendino, M Solé, C Montironi, À Ginès
Journal: Endoscopy (2016)

Introducción: La PAAF del CWD se ha evitado clásicamente por temor a complicaciones, aunque el riesgo no está bien establecido. La prevalencia creciente de neoplasia mucinosa papilar intraductal (NPMI) y las dificultades para el diagnóstico diferencial entre pancreatitis crónica (PC) y NMPI hacen que la investigación de la causa de dilatación del C. Wirsung sea crucial.
Advancing Alternative Analysis: Integration of Decision Science
Authors: Timothy F. Malloy, Virginia M. Zaunbrecher, Christina M. Batteate, Ann Blake, William F. Carroll, Charles J. Corbett, Steffen Foss Hansen, Robert J. Lempert, Igor Linkov, Roger McFadden, Kelly D. Moran, Elsa Olivetti, Nancy K. Ostrom, Michelle Romero, Julie M. Schoenung, Thomas P. Seager, Peter Sinsheimer, Kristina A. Thayer
Journal: Environmental Health Perspectives (2016)

Decision analysis-a systematic approach to solving complex problems-offers tools and frameworks to support decision making that are increasingly being applied to environmental challenges. Alternatives analysis is a method used in regulation and product design to identify, compare, and evaluate the safety and viability of potential substitutes for hazardous chemicals.We assessed whether decision science may assist the alternatives analysis decision maker in comparing alternatives across a range of metrics.A workshop was convened that included representatives from government, academia, business, and civil society and included experts in toxicology, decision science, alternatives assessment, engineering, and law and policy. Participants were divided into two groups and were prompted with targeted questions. Throughout the workshop, the groups periodically came together in plenary sessions to reflect on other groups' findings.We concluded that the further incorporation of decision science into alternatives analysis would advance the ability of companies and regulators to select alternatives to harmful ingredients and would also advance the science of decision analysis.We advance four recommendations: a) engaging the systematic development and evaluation of decision approaches and tools; b) using case studies to advance the integration of decision analysis into alternatives analysis; c) supporting transdisciplinary research; and d) supporting education and outreach efforts. https://doi.org/10.1289/EHP483.
TCT-350 Clinical Results At A Long-Term Follow-Up Of Percutaneous Coronary Intervention In Left Main Coronary Artery Disease
Authors: Jesus Piqueras-Flores, Ignacio Sanchez-Perez, Alfonso Jurado, María Thiscal López Lluva, Natalia Pinilla-Echeverri, Andrea Moreno-Arciniegas, Manuel Marina-Breysse, Fernando Lozano
Journal: Journal of the American College of Cardiology (2016)
Mechanisms of Ascites Development—Reply
Authors: Yuval A. Patel, Andrew J. Muir
Journal: JAMA (2016)

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TCT-669 Valve-in-Valve in Small Surgical Valves: Predictors for Survival and Elevated Post Procedural Gradients. Insights from the Valve-in-Valve International Data (VIVID) Registry
Authors: Matheus Simonato dos Santos, Mohamed Abdel-Wahab, David Hildick-Smith, John Webb, Yaron Arbel, Hafid Amrane, Brian Whisenant, Matthew Miller, Marco Agrifoglio, Stefano Salizzoni, Patrizia Presbitero, Christian Frerker, Vasco Gama Ribeiro, Helene Eltchaninoff, Arend de Weger, Alfredo Cerillo, Ariel Finkelstein, Luca Testa, Tobias Zeus, Claudia Fiorina, Piotr Chodor, Dan Ioanes, Neil Moat, Danny Dvir
Journal: Journal of the American College of Cardiology (2016)
USE VS PET-TAC EN LA ESTADIFICACIÓN Y LA REESTADIFICACIÓN DE CÁNCER GÁSTRICO
Authors: F Valverde López, JG Martínez Cara, R Jímenez Rosales, E Redondo Cerezo
Journal: Endoscopy (2016)

Introducción: El cáncer gástrico es uno de los tumores malignos más comunes en el tracto gastrointestinal, variando la actitud terapéutica según la estadificación preopeatoria (desde tratamiento endoscópico hasta la terapia neoadyuvante), siendo la precisión en este esencial.
MORTALIDAD INTRAHOSPITALARIA Y A LARGO PLAZO POR HDA, ANALISIS PROSPECTIVO DE UNA COHORTE DE PACIENTES
Authors: R Jiménez-Rosales, JG Martínez-Cara, F Valverde-López, M López De Hierro-Ruiz, E Redondo-Cerezo
Journal: Endoscopy (2016)

Introducción: La hemorragia digestiva alta(HDA) es causa frecuente de ingreso hospitalario, con una mortalidad intrahospitalaria entre 2 – 15%. Se han estudiado múltiples factores predictivos de mortalidad, sin embargo, esta no siempre se debe a la HDA, sino a descompensación de otras comorbilidades, en las que la HDA es sólo intercurrente.
FV-162 Is a Novel Orally Bioavailable Proteasome Inhibitor With Improved Pharmacokinetics That Displays Preclinical Efficacy In Vitro and In Vivo
Authors: Zezhou Wang, Peter Dove, Xiaoming Wang, Carolyn A. Goard, Zhihua Li, Alex Nachman, Yoonsun Jenny Oh, Rose Hurren, Amy Ruschak, Shane Climie, David O'Neill, Barry Press, Carly Griffin, Elijus Undzys, Ahmed Aman, Rima Al-awar, Lewis Kay, Suzanne Trudel, Malik Slassi, Aaron Schimmer
Journal: Blood (2013)
TCT-159 Impact of Staged versus One-Time Multivessel Percutaneous Intervention in ST-elevation Myocardial Infarction: A Meta-analysis
Authors: Pedro Villablanca, Mohammed Makkiya, Divyanshu Mohananey, Agata Leśniak-Sobelga, Rasha Al-Bawardy, Jerson Munoz Mendoza, Miguel Alvarez, Maday Gonzalez, Daniel Pu, Aman Shah, Arrash Fard, R. Paweł Banyś, Anna Bortnick, mark menegus, Robert Pyo, Scott Monrad, Hayder Hashim, Jose Wiley, Harish Ramakrishna, David Slovut, David Briceno
Journal: Journal of the American College of Cardiology (2016)