Radiation-Induced Breast Cancer
Authors: Diana L. Miglioretti, Christoph I. Lee
Journal: Annals of Internal Medicine (2016)

Letters20 September 2016Radiation-Induced Breast CancerDiana L. Miglioretti, PhD and Christoph I. Lee, MD, MSHSDiana L. Miglioretti, PhDFrom University of California, Davis, Davis, California, and University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington.Search for more papers by this author and Christoph I. Lee, MD, MSHSFrom University of California, Davis, Davis, California, and University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0364 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Drs. Phillips and Blumhardt that the benefit of reduced breast cancer mortality associated with guideline-based screening mammography outweighs the risks for radiation-induced breast cancer, as stated in our article. Likewise, we hope that women do not forgo mammography because of fears of radiation-induced breast cancer; however, that outcome is not a valid reason not to estimate and report these risks. Radiation exposure from mammography screening is a potential harm, even if a relatively small one, that should be considered when evaluating the benefit–harm tradeoff of different screening strategies.To model breast cancer risk from radiation ...References1. Preston DL, Mattsson A, Holmberg E, Shore R, Hildreth NG, Boice JD. Radiation effects on breast cancer risk: a pooled analysis of eight cohorts. Radiat Res. 2002;158:220-35. [PMID: 12105993] CrossrefMedlineGoogle Scholar2. Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation and National Research Council. Health Risks from Exposure to Low Levels of Ionizing Radiation: BEIR VII Phase 2. Washington, DC: National Academies Pr; 2006. Google Scholar3. Ozasa K, Shimizu Y, Suyama A, Kasagi F, Soda M, Grant EJ, et al. Studies of the mortality of atomic bomb survivors, report 14, 1950-2003: an overview of cancer and noncancer diseases. Radiat Res. 2012;177:229-43. [PMID: 22171960] CrossrefMedlineGoogle Scholar4. Lam DL, Larson DB, Eisenberg JD, Forman HP, Lee CI. Communicating potential radiation-induced cancer risks from medical imaging directly to patients. AJR Am J Roentgenol. 2015;205:962-70. [PMID: 26295534] doi:10.2214/AJR.15.15057 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University of California, Davis, Davis, California, and University of Washington and Fred Hutchinson Cancer Research Center, Seattle, Washington.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1241. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRadiation-Induced Breast Cancer Incidence and Mortality From Digital Mammography Screening Diana L. Miglioretti , Jane Lange , Jeroen J. van den Broek , Christoph I. Lee , Nicolien T. van Ravesteyn , Dominique Ritley , Karla Kerlikowske , Joshua J. Fenton , Joy Melnikow , Harry J. de Koning , and Rebecca A. Hubbard Radiation-Induced Breast Cancer William T. Phillips and Ralph Blumhardt Metrics 20 September 2016Volume 165, Issue 6Page: 452KeywordsBreast cancerDiagnostic radiologyDisclosureFearIonizing radiationMammographyMortalityRadiation exposureRisk managementSurvival analysis ePublished: 20 September 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...