tbuckley/cabot-search huggingface dataset:
Nodular Fasciitis Mimicking Soft Tissue Metastasis on 18F-FDG PET/CT During Surveillance
Authors: Ji Young Kim, Jina Park, Yun Young Choi, Seunghun Lee, Seung Sam Paik
Journal: Clinical Nuclear Medicine (2014)

Nodular fasciitis (NF) is a common benign soft tissue tumor. However, 18F-FDG PET/CT findings of NF are limited. Two cases of NF are described that mimic soft tissue metastasis on 18F-FDG PET/CT during surveillance. 18F-FDG PET/CT is well documented in the surveillance of malignancy and increasing worldwide. There are growing chances of encountering FDG-avid nonmalignant soft tissue lesion. Nodular fasciitis could be considered as possible diagnosis on 18F-FDG PET/CT if a solitary well- circumscribed ovoid hypermetabolic soft tissue lesion is located in a muscle, intermuscular space, or adjacent tendon, especially in patients with a clinically low probability of tumor recurrence or metastasis.
Abstract 2539: Survival of lymphoma and beverages consumptions; alcohol, tea and coffee: results from National Cancer Centre, Singapore lymphoma cohort.
Authors: Yin Leng Lee, Kevin Kuang Wei Tay, Soo Yong Tan, Leonard Tan, Richard Hong Hui Quek, Miriam Tao, Tam Cam Ha, Soon Thye Lim
Journal: Cancer Research (2013)

Abstract Background: In 2008, Singapore Cancer Registry reported lymphoma age-standardized rate (ASR) among males and females was 11.2 per 100,000 and 7.5 per 100,000, respectively with highest incidence observed in Malays, followed Chinese and Indians. Lymphoma incidence rates have been increasing since 1968 (female; ASR: 1.8 per 100,000) and is now the seventh and ninth most common cause of cancer for both men and women, respectively. Lymphoma is widely studied but the cause is yet to be ascertained. Epidemiological studies have shown modifiable behaviour such as heavy alcohol use results in poorer survival across various cancer types in Western population while reviews of tea and coffee consumptions in association with survival are limited. Here, we examined the impact of beverages consumption; alcohol, tea and coffee on lymphoma survival in South East Asia. Methods: A cohort of 384 lymphoma patients with confirmed histology was recruited from January 2004 to December 2009 and was prospectively followed through till July 2012. At diagnosis, lifestyle characteristics were assessed using a structured questionnaire. Cox proportional hazards regression was used to estimate the prognostic value of three beverages; alcohol, tea and coffee, on lymphoma survival adjusted for other clinical prognostic factors; LDH, ECOG, Ann Arbor stage and extra-nodal sites. Results: The overall median follow-up was 4.2 years (range: 0.02 to 8.3). Among all lymphoma subtypes, the most prevalent was DLBCL, 183 (47.7%) with highest incidence among Chinese, 305 (79.4%) followed by Malay 53 (13.8%) and Indian 24 (6.3%). Alcohol consumptions were associated with poorer survival for all lymphoma (ptrend=0.004) with increasing alcohol use whereas female black tea (plog-rank=0.0063) and coffee (plog-rank=0.018) consumptions had lower risk of death compared to non-drinkers. Full model including alcohol (one or more drinks per day; HR=2.35, 95% CI: 1.38-4.00, p=0.002) and clinical prognostic factors results in c index, 0.75 and 0.72, for overall survival and progression free survival, respectively. Conclusion: Alcohol consumption in our cohort is predictive of survival while tea and coffee had a weak survival association among lymphoma. This model warrant external validation. Citation Format: Yin Leng Lee, Kevin Kuang Wei Tay, Soo Yong Tan, Leonard Tan, Richard Hong Hui Quek, Miriam Tao, Tam Cam Ha, Soon Thye Lim. Survival of lymphoma and beverages consumptions; alcohol, tea and coffee: results from National Cancer Centre, Singapore lymphoma cohort. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2539. doi:10.1158/1538-7445.AM2013-2539
Another option for biliary access in post-bypass patient: intentional disruption of a gastric staple line
Authors: J. Levenick, T. Gardner
Journal: Endoscopy (2013)

Obese and post-Roux-en-Y gastric bypass (RYGB) patients are at increased risk of cholelithiasis and associated biliary disorders [1] [2] [3]. Because of the complicated postsurgical anatomy, endoscopic retrograde cholangiopancreatography (ERCP) may be more difficult, requiring deep enteroscopy or laparoscopic assistance. We report a case of intentional disruption of the gastric remnant-excluded stomach staple line to gain access to the duodenum for treatment of choledocholithiasis.
Auxiliary Partial Liver Transplantation for End-Stage Chronic Liver Disease
Authors: Onno T. Terpstra, Solko W. Schalm, Willem Weimar, Pierre J.A. Willemse, Dieter Baumgartner, Theo H.N. Groenland, Fibo W.J. ten Kate, Robert J. Porte, Sjoerd de Rave, Cornelis B. Reuvers, Jeanne Stibbe, Johan L. Terpstra
Journal: New England Journal of Medicine (1988)

Auxiliary heterotopic liver transplantation is theoretically attractive because it leaves the recipient's liver in place. The surgical trauma of hepatectomy is avoided, and failure of the graft does not necessarily lead to the death of the patient or a second, emergency transplantation. Another advantage is that matching the body sizes of the donor and the recipient is not mandatory, which increases the number of possible donors. However, previous clinical results of auxiliary liver transplantation have been poor. We performed auxiliary partial liver transplantation in six consecutive patients with end-stage chronic liver disease who were not accepted for orthotopic liver transplantation because they had massive ascites, deficient clotting function, cachexia, or poor pulmonary reserve. The donor liver was transplanted to the right subhepatic region after removal of segments II and III, and it was provided with portal and arterial blood. There were no major changes in hemodynamic measurements during surgery. The mean hospital stay after transplantation was 22.7 days (range, 14 to 29). After a mean follow-up period of 14 months (range, 5 to 23), all patients were alive, with good graft function as demonstrated by scintigraphy, Doppler ultrasonography, and synthesis of clotting factors. From these observations we conclude that auxiliary partial liver transplantation is an attractive alternative to orthotopic liver transplantation in high-risk patients. Its role in other patients who need liver transplants remains to be defined. (N Engl J Med 1988; 319:1507–11.)
Current approaches to hematopoietic stem-cell purging in chronic myeloid leukemia.
Authors: S G O'Brien, J M Goldman
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.3.541 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7884413 Current approaches to hematopoietic stem-cell purging in chronic myeloid leukemia. S G O'BrienxS G O'BrienSearch for articles by this author , J M GoldmanxJ M GoldmanSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.3.541 First Page PDF © 1995 by American Society of Clinical Oncology
USEFULNESS OF TPEAK-TEND INTERVAL TO DISTINGUISH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY FROM IDIOPATHIC RIGHT VENTRICULAR OUTFLOW TACHYCARDIA
Authors: Kivanc Yalin, Ebru Golcuk, Ahmet Kaya Bilge, Kamil Adalet
Journal: Journal of the American College of Cardiology (2013)
EFFICACY AND SAFETY OUTCOMES OF CATHETER-BASED INTERVENTION FOR TREATMENT OF ACUTE SEVERE PULMONARY EMBOLISM: A COMPREHENSIVE META-ANALYSIS
Authors: Rajat Kalra, Navkaranbir Bajaj, William J. Lancaster, Jason Guichard, Fabio Raman, Donald Clark, David McGiffin, Mustafa Ahmed
Journal: Journal of the American College of Cardiology (2015)
PWE-063 Effectiveness of general hypnotherapy and gut-directed hypnotherapy in refractory irritable bowel syndrome: Abstract PWE-063 Table 1
Authors: V S Hegade, N Mohammed, A Barnett, M Denyer
Journal: Gut (2012)

<h3>Introduction</h3> Irritable bowel syndrome (IBS) is a very common condition, which constitutes up to 50% of Gastroenterology outpatient referrals. Many pharmacological and non-pharmacological treatments are available with variable results. Hypnotherapy is generally reserved for refractory IBS patients. Although there is ample evidence to show the effectiveness of Gut-directed Hypnotherapy (GDH), there are only few studies to support other forms of hypnotherapy especially general hypnotherapy. Aim of this study was to assess the effectiveness of different types of hypnotherapy on refractory IBS patients treated in our institution, a tertiary referral centre. <h3>Methods</h3> In our institution, an experienced hypnotherapist assesses refractory IBS patients. Based on their symptoms, patients receive either general hypnotherapy (GH), GDH or both. All patients score their IBS symptoms on IBS Symptom Score sheet [0–10 Likert scale, minimum score 0, maximum 60] first at the baseline (Pre-hypnotherapy score) and then at the end of the hypnotherapy (Immediate Post-hypnotherapy score). Patients also complete Hospital Anxiety and Depression (HAD) score sheet before and after hypnotherapy. We analysed the data of all patients treated with hypnotherapy between February 2009 and December 2011. Follow-up questionnaires were sent to all patients in the post at variable periods after the completion of hypnotherapy to score their current symptoms (Long-term Post-hypnotherapy score). Parametric methods were used for statistical analysis. <h3>Results</h3> During the study period, 34 patients (n=34, females 29, mean age 41.5) received hypnotherapy (GH=15, GDH=8, both =11). Average number of hypnotherapy sessions was 4.7 (range 3–6, 1 h/week). Seventeen (50%) patients returned their follow-up questionnaires. Mean duration between the last session of hypnotherapy and completion of the follow-up questionnaire was 16 months (range 5–32). Abstract PWE-063 table 1 shows the main results. <h3>Conclusion</h3> Our study suggests that treatment of refractory IBS patients with general hypnotherapy, either alone or in combination with gut-directed hypnotherapy is effective both in short and long term. These results need to be confirmed in prospective randomised controlled studies directly comparing general hypnotherapy against gut-directed hypnotherapy. <h3>Competing interests</h3> None declared.
C10
Authors: William H. Howard, Stephen R. Bunker, Jack L. Lancaster, Michael A. Cawthon, Michael F. Hartshorne, Robert D. Karl, John M. Bauman
Journal: Clinical Nuclear Medicine (1984)

Howard, William H. III; Bunker, Stephen R.; Lancaster, Jack L.; Cawthon, Michael A.; Hartshorne, Michael F.; Karl, Robert D. Jr.; Bauman, John M.Author Information
Abstract 5124: Signaling networks potentially involved in breast cancer metastasis to the brain
Authors: Feng Li, Olga V. Glinskii, Landon Wilson, Stephen Barnes, Douglas C. Anthony, Vladislav V. Glinsky
Journal: Cancer Research (2011)

Abstract Brain is a common site of breast cancer metastasis and is associated with significant neurologic morbidity, decreased quality of life, and greatly shortened survival. However, the molecular and cellular mechanisms underpinning brain colonization by breast carcinoma cells are poorly understood. In this study, we used 2D-DIGE (Difference in Gel Electrophoresis) proteomic analysis followed by LC-tandem mass spectrometry to identify the proteins differentially expressed in brain-targeting breast carcinoma cells (MB231-Br) compared with parental MDA-MB-231 cell line. Between the two cell lines, we identified 12 proteins consistently exhibiting greater than 2-fold (p&amp;lt;0.05) difference in expression, which were associated by the Ingenuity Pathway Analysis (IPA) with two major signaling networks involving TNFα/TGFβ-, NFκB-, HSP-70-, TP53-, and IFNγ-associated pathways. Remarkably, highly related networks were revealed by the IPA analysis of a list of 19 brain-metastasis-associated proteins identified recently by the group of Dr. A. Sierra using MDA-MB-435-based experimental system (Martin et al., J Proteome Res 2008 7:908-20), or a 17-gene classifier associated with breast cancer brain relapse reported by the group of Dr. J. Massague based on a microarray analysis of clinically annotated breast tumors from 368 patients (Bos et al., Nature 2009 459: 1005-9). Even though only 2 out of 31 proteins were common between the MDA-MB-231-based set identified by our group in this study and MB-435-based set reported by Martin et al., and none of these proteins were present in a 17-gene brain relapse signature published by Bos et al., they all converged on the major signaling networks involving TNFα/TGFβ-, NFκB-, HSP70-, TP53-, and IFNα/γ-related pathways. Our results show that different experimental systems and approaches (2D-DIGE proteomics used on brain targeting cell lines or gene expression analysis of patient samples with documented brain relapse) yield highly related signaling networks. These findings suggest strongly that these signaling networks may be essential for colonization of the brain by metastatic breast carcinoma cells. This work was supported in part by Award Number 1I01BX000609 from the Biomedical Laboratory Research &amp; Development Service of the VA Office of Research and Development to VVG and AHA National SDG 0830287N to OVG. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5124. doi:10.1158/1538-7445.AM2011-5124
Overview: Workshop on Fiber Toxicology Research Needs
Authors: John M. Dement
Journal: Environmental Health Perspectives (1990)

pers were prepared and distributed to conference participants. These review papers were presented and discussed during the first day of the workshop. During the second day participants were divided into four subgroups that addressed research needs in the areas of exposure assessment, in vitro studies, animal toxicology studies, and human epidemiology. The workshop's final day consisted of presentations and discussions of research recommendations developed during the four concurrent sessions. The critical review papers are published in this volume. The following are reports from each of the subgroups.
Abstract A67: Regulation of Eag1 expression by steroid hormones in cervical cancer cells
Authors: Jesus Adrian Rodriguez-Rasgado, Lorenza Diaz, Rocio Garcia-Becerra, Euclides Avila, Javier Camacho
Journal: Cancer Research (2009)

Abstract Introduction: Ether à go-go 1 (Eag1) channels have oncogenic properties. This channel is widely expressed in human tumors. It has been shown that inhibition of its expression and/or activity reduces cellular proliferation. Some cancer-associated factors up-regulate Eag1 expression; including estradiol and the E6 and E7 human papilloma virus (HPV) oncogenes. On the other hand, calcitriol (the most active metabolite of vitamin D) has shown antiproliferative properties and it has been considered as a potential anticancer treatment. In this work, we studied Eag1 regulation by estradiol, tamoxifen, ICI 182 780, genistein and calcitriol in the cervical cancer cell line SiHa, that express E6 an E7 HPV oncogenes. Methods: SiHa cells were cultivated with DMEM without phenol red and were treated with estradiol, tamoxifen, ICI 182 780, genistein or calcitriol during 48 hours. Total RNA was obtained with Trizol reagent, and cDNA was synthesized. Eag1 expression was evaluated by real time PCR. Eag1 expression was normalized against the housekeeping gene GAPDH. Using XTT colorimetric assay we evaluated the effect of calcitriol on SiHa cells proliferation. Results: Calcitriol decreased cell proliferation after 5 days of culture. We also identified estrogen receptors α and β and VDR (vitamin D receptor) proteins by Western blot. Estradiol, antiestrogens, genistein and calcitriol down-regulated Eag1 mRNA expression. Concomitant treatment of SiHa cells with estradiol and calcitriol seems to potentiate such Eag1 down-regulation. On the other hand, SiHa cells expressed higher levels of ERβ than ERα. Conclusions: Our data suggest that down regulation of Eag1 by calcitriol could be a new mechanism by which calcitriol reduce tumor cells proliferation. Together, estradiol, antiestrogens, genistein and calcitriol could be used as treatment for cancers that present ER pattern expression silimar to SiHa cells. Citation Information: Cancer Res 2009;69(23 Suppl):A67.
THU0054 Interleukin-33/St2 Axis in Primary SjÖGren's Syndrome: Expression in Serum and Salivary Gland, and Clinical Association
Authors: S.M. Jung, J.Y. Kang, H.K. Min, J.H. Koh, Y.S. Suh, J.H. Lee, J. Lee, J.Y. Lee, J.-M. Kim, J.H. Ju, K.-S. Park, S.-H. Park, H.-Y. Kim, S.-K. Kwok
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> IL-33 and its receptor, ST2, are associated with many inflammatory disorders. However, the data on IL-33/ST2 in Sjögren9s syndrome (SS) is very limited. <h3>Objectives</h3> To evaluate the expression of IL-33 and its receptor in sera and salivary tissues obtained from patients with primary Sjögren9s syndrome (pSS) and to investigate the possible relationship with clinical profiles. <h3>Methods</h3> Serum IL-33 and soluble ST2 (sST2) of 55 patients with pSS and 48 controls were determined using ELISA, and assessed for correlation with clinical profiles. The expression of IL-33/ST2 in salivary tissues was investigated by immunohistochemical (IHC) staining, and was further characterized by confocal microscopy. We also measured ST2 expression in peripheral blood mononuclear cells (PBMCs) of pSS patients, and IL-33 production in salivary glandular epithelial cell by pro-inflammatory stimuli. <h3>Results</h3> The serum levels of IL-33 and sST2 were higher in pSS patients compared to healthy controls (<i>P</i>=0.018 and <i>P</i>&lt;0.0001, respectively). Among pSS patients, serum sST2 concentration was associated with thrombocytopenia (<i>P</i>=0.029) and duration of disease (<i>p</i>=0.013). Contrary to sST2, ST2 was downregulated in PBMCs obtained from pSS patients. The expression of IL-33 and ST2 was elevated in salivary gland of pSS patients with grade 2 inflammation, and decreased as inflammation progresses. In pSS patients, IL-33 was mainly observed in epithelial cells and endothelial cells of gland tissue. The production of IL-33 mRNA by salivary gland epithelial cell line was increased under stimulation with interferon-γ. <h3>Conclusions</h3> IL-33 and sST2 concentrations were elevated in sera of pSS patients, whereas ST2 in salivary gland and PBMC of pSS patients showed downregulated expression. This result suggests that IL-33/ST2 axis might have a role in the pathogenesis of pSS. <h3>References</h3> Schmitz, J., et al., IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. Immunity, 2005. 23(5): p. 479-90. Palmer, G. and C. Gabay, Interleukin-33 biology with potential insights into human diseases. Nat Rev Rheumatol, 2011. 7(6): p. 321-9. Moussion, C., N. Ortega, and J.P. Girard, The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel `9alarmin"? PLoS One, 2008. 3(10): p. e3331. <h3>Acknowledgements</h3> This study was supported by a grant from the Korea Healthcare Technology R&amp;D Project, Ministry of Health and Welfare, Republic of Korea (HI13C0016). <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4921
RENDIMIENTO DIAGNOSTICO DE ECOENDOSCOPIA Y CPRE CUANDO EXISTE DILATACION DE VIAS BILIARES
Authors: V Jaramillo, R Romero, J Romero, F Pellicer, A Caunedo, JM Herrerías
Journal: Endoscopy (2014)

Introducción: La dilatación de vías biliares es un hallazgo frecuente en pacientes con colestasis, aunque no siempre se evidencia su causa por las técnicas de imagen convencionales (TAC/RMN).
AUGMENTATION OF CARDIAC SYMPATHETIC TONE BY LOW LEVEL STELLATE GANGLION STIMULATION IN HUMANS
Authors: Olujimi Ajijola, Kimberly Howard-Quijano, Jennifer Scovotti, Christine Lee, Marmar Vaseghi, Aman Mahajan, Kalyanam Shivkumar
Journal: Journal of the American College of Cardiology (2015)
Pleiotropic Effects of HDL Subfraction and Associated Enzymes on Protection Against Coronary Artery Disease
Authors: Mehmet Bostan, Hüseyin Avni Uydu, Zakir Karadağ, Mehtap Atak, Yavuz Uğurlu, Elif Ergül, Ömer Şatıroğlu, Adnan Yılmaz
Journal: Journal of the American College of Cardiology (2013)
EMMPRIN-Targeted Magnetic Nanoparticles for In Vivo Visualization and Regression of Acute Myocardial Infarction
Authors: Irene Cuadrado, Maria Jose Garcia Miguel Piedras, Irene Herruzo, Maria del Carmen Turpin, Borja Castejón, Paula Reventun, Ana Martin, Marta Saura, Jose Luis Zamorano, Carlos Zaragoza
Journal: Theranostics (2016)

Inhibition of extracellular matrix (ECM) degradation may represent a mechanism for cardiac protection against ischemia.Extracellular matrix metalloproteinase inducer (EMMPRIN) is highly expressed in response to acute myocardial infarction (AMI), and induces activation of several matrix metalloproteinases (MMPs), including gelatinases MMP-2 and MMP-9.We targeted EMMPRIN with paramagnetic/fluorescent micellar nanoparticles conjugated with the EMMPRIN binding peptide AP-9 (NAP9), or an AP-9 scrambled peptide as a negative control (NAPSC).We found that NAP9 binds to endogenous EMMPRIN in cultured HL1 myocytes and in mouse hearts subjected to ischemia/reperfusion (IR).Injection of NAP9 at the time of or one day after IR, was enough to reduce progression of myocardial cell death when compared to Control and NAPSC injected mice (infarct size in NAP9 injected mice: 32%±6.59vs Control: 46%±9.04 or NAPSC injected mice: 48%±7.64).In the same way, cardiac parameters were recovered to almost healthy levels (LVEF NAP9 63% ± 7.24 vs Control 42% ± 4.74 or NAPSC 39% ± 6.44), whereas ECM degradation was also reduced as shown by inhibition of MMP-2 and MMP-9 activation.Cardiac magnetic resonance (CMR) scans have shown a signal enhancement in the left ventricle of NAP9 injected mice with respect to non-injected, and to mice injected with NAPSC.A positive correlation between CMR enhancement and Evans-Blue/TTC staining of infarct size was calculated (R:0.65).Taken together, these results point to EMMPRIN targeted nanoparticles as a new approach to the mitigation of ischemic/reperfusion injury.
NONINVASIVE VESSEL-SPECIFIC ABSOLUTE MYOCARDIAL BLOOD FLOW AND FLOW RESERVE BY MEANS OF DYNAMIC NH3 PET/CTA IMAGE FUSION: DEVELOPMENT OF NORMAL LIMITS
Authors: Marina Piccinelli, Hee-Seung Bom, Erick Alexanderson, David Cooke, Russell Folks, Daya Manatunga, Ernest Garcia
Journal: Journal of the American College of Cardiology (2016)