New Studies Do Not Challenge the American College of Cardiology/American Heart Association Lipid Guidelines
Authors: Thomas F. Whayne
Journal: Annals of Internal Medicine (2016)

Letters6 December 2016New Studies Do Not Challenge the American College of Cardiology/American Heart Association Lipid GuidelinesThomas F. Whayne Jr, MD, PhDThomas F. Whayne Jr, MD, PhDFrom Gill Heart Institute, University of Kentucky, Lexington, Kentucky.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0418 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Hofer and colleagues (1) offer more controversy and potential confusion about a targeted or tailored reduction of low-density lipoprotein cholesterol (LDL-C) levels because they firmly state that the available new clinical evidence reinforces the importance of cardiovascular risk and the secondary importance of these levels. Hayward and Krumholz (2) first proposed eliminating LDL-C targets. Nevertheless, multiple interventions (such as ileal bypass) have for many years established the cardiovascular risks and benefits of reducing LDL-C levels, long before consideration of the additional pleiotropic effects of statins (3).High-risk patients with cardiovascular disease whose physicians have paid no attention ...References1. Hofer TP, Sussman JB, Hayward RA. New studies do not challenge the American College of Cardiology/American Heart Association lipid guidelines. Ann Intern Med. 2016;164:683-4. [PMID: 26857151]. doi:10.7326/M15-2428 LinkGoogle Scholar2. Hayward RA, Krumholz HM. Three reasons to abandon low-density lipoprotein targets: an open letter to the Adult Treatment Panel IV of the National Institutes of Health [Letter]. Circ Cardiovasc Qual Outcomes. 2012;5:2-5. [PMID: 22253366] doi:10.1161/CIRCOUTCOMES.111.964676 CrossrefMedlineGoogle Scholar3. Buchwald H, Varco RL, Boen JR, Williams SE, Hansen BJ, Campos CT, et al. Effective lipid modification by partial ileal bypass reduced long-term coronary heart disease mortality and morbidity: five-year posttrial follow-up report from the POSCH. Program on the Surgical Control of the Hyperlipidemias. Arch Intern Med. 1998;158:1253-61. [PMID: 9625405] CrossrefMedlineGoogle Scholar4. Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2014;63:2889-934. [PMID: 24239923] doi:10.1016/j.jacc.2013.11.002 CrossrefMedlineGoogle Scholar5. Whayne TF. Assessment of low-density lipoprotein targets. Angiology. 2013;64:411-6. [PMID: 22734087] doi:10.1177/0003319712451115 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Gill Heart Institute, University of Kentucky, Lexington, Kentucky.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0418. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoNew Studies Do Not Challenge the American College of Cardiology/American Heart Association Lipid Guidelines Timothy P. Hofer , Jeremy B. Sussman , and Rodney A. Hayward New Studies Do Not Challenge the American College of Cardiology/American Heart Association Lipid Guidelines Timothy P. Hofer and Rodney A. Hayward Metrics Cited byOn P values and effect modification 6 December 2016Volume 165, Issue 11Page: 827KeywordsCardiovascular disease riskCholesterolHeartLipidsLow density lipoproteinLow density lipoprotein cholesterolMedical risk factorsPatient advocacyRisk assessmentsStatins ePublished: 6 December 2016 Issue Published: 6 December 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...