tbuckley/cabot-search huggingface dataset:
CBL-C137, a Curaxin and Potent Suppressor Of NF-Kb Activity and Modulator Of p53 Function Is Active In Rituximab-Sensitive Or Resistant Activated B-Cell (ABC) Diffuse Large B-Cell Lymphoma (DLBCL) Cells
Authors: Christopher N. Ibabao, Cory Mavis, Jenny Gu, Myron S. Czuczman, Francisco Hernandez
Journal: Blood (2013)
PORPHYRIA CUTANEA TARDA AND CHLORACNE
Authors: F W MOUNT
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bone morphogenetic protein signaling promotes tumorigenesis in a murine model of high-grade glioma
Authors: Laura D. Hover, Philip Owens, Alexander L. Munden, Jialiang Wang, Lola B. Chambless, Corey R. Hopkins, Charles C. Hong, Harold L. Moses, Ty W. Abel
Journal: Neuro-Oncology (2015)

Improved therapies for high-grade glioma (HGG) are urgently needed as the median survival for grade IV gliomas is only 15 months. Bone morphogenetic protein (BMP) signaling plays critical and complex roles in many types of cancer, including glioma, with most of the recently published work focusing on BMP-mediated regulation of glioma stem cells (GSCs). We hypothesized that BMP signaling may be an important modulator of tumorigenic properties in glioma cells outside of the GSC compartment. We used a human HGG tissue microarray and performed immunohistochemistry for phospho-Smads1,5,8. To examine the role of BMP signaling in tumorigenic astrocytes, transgenic mice were used to delete the BMP type IA receptor (Bmpr1a) and generate astrocytes transformed with oncogenic Ras and homozygous deletion of p53. The cells were transplanted orthotopically into immunocompetent adult host mice. First we established that BMP signaling is active within the vast majority of HGG tumor cells. Mice implanted with BMPR1a-knockout transformed astrocytes showed an increase in median survival compared with mice that received BMPR1a-intact transformed astrocytes (52.5 vs 16 days). In vitro analysis showed that deletion of BMPR1a in oncogenic astrocytes resulted in decreased proliferation, decreased invasion, decreased migration, and increased expression of stemness markers. In addition, inhibition of BMP signaling in murine cells and astrocytoma cells with a small molecule BMP receptor kinase inhibitor resulted in similar tumor suppressive effects in vitro. BMP inhibition may represent a viable therapeutic approach in adult HGG.
CBIO-09ENHANCED MITOCHONDRIAL RESPIRATION IN SLOW-CYCLING GLIOMA STEM CELLS
Authors: Loic Deleyrolle, Lan Hoang-Minh, Michael Schmoll, Jaimin Patel, Alvin Vuong, Krisha Amin, Regina Martuscello, Benjamin Griffith, Vinata Vedam-Mai, Matthew Sarkisian, Brent Reynolds
Journal: Neuro-Oncology (2015)

INTRODUCTION: Tumorigenesis and resistance to treatment result from the ability of specific subpopulations of tumor cells to expand and survive. Conventional therapies effectively eliminate rapidly dividing cells, which derive their energy from aerobic glycolysis, but spare slowly dividing populations. We previously reported the existence of slow-cycling cells that exhibit cancer stem cell (CSC) characteristics and resistance to therapies in glioblastoma (GB). Clinical strategies targeting this specific phenotype could lead to improved therapeutic outcomes and reduce disease progression or recurrence. OBJECTIVES: Metabolic reprogramming is now a well- recognized hallmark of cancers and represents a promising therapeutic target. The primary objective of this study was to characterize the energetic properties of CSCs, especially slow-cycling cells. METHODS: Slow and fast-cycling cells were isolated from patient-derived primary GB cells via a dye retention assay using carboxy fluorescein succinimidyl ester. RESULTS: Mass spectrometry-based metabolite screening revealed metabolic heterogeneity with differential metabolic signatures between GB fast and slow-cycling cells. An OxPhos profile was validated in the slow-cycling cells by the observation of greater mitochondrial activity as well as upregulation of key proteins involved in the Krebs cycle and mitochondrial electron transport chain, such as pyruvate dehydrogenase, NADH dehydrogenase, and ATP synthase. Conversely, glycolytic proteins such as lactate dehydrogenase A were upregulated in fast-cycling cells. We also found that the slow-cycling fraction was less sensitive to glucose restriction than the fast-cycling portion, as shown by increased survival in glucose-deprived conditions, suggesting ability to metabolize diverse energy sources. CONCLUSION: These studies demonstrate metabolic diversity in GB and suggest that GB slow-cycling cells, exhibiting catabolic adaptability, utilize OxPhos to meet energy demands. This represents an unexpected selective vulnerability in GB cells that could be targeted for therapy.
The GILUPI CellCollector as an in vivo tool for circulating tumor cell enumeration and molecular characterization in lung cancer patients.
Authors: Klaus Luecke, Lukasz Gasiorowski, Stefanie Herold, Nora Brychta, Giulia Gallerani, Thomas Krahn, Francesco Fabbri, Wojciech Dyszkiewicz, Christian Schumann
Journal: Journal of Clinical Oncology (2015)

e22035 Background: Tumor tissue based analysis is not always possible and represents only a single-snapshot in time. Liquid biopsy can supply further information on prognosis, treatment efficacy and molecular tumor evolution by isolating and analyzing circulating tumor cells (CTCs). Usually, CTCs are isolated in vitro from limited volumes of patient blood samples. To overcome this limitation, the GILUPI CellCollector was used in lung cancer patients to isolate CTCs in vivoin comprehensive studies. We showed the high efficient isolation results combined with mutations detection (EGFR and KRAS) in CTCs of patients with known primary tumor mutation. In addition new molecular assays for CTCs isolated with the GILUPI CellCollector were established (characterization of ALK, PD-L1) - making it an ideal tool for liquid biopsy and clinical diagnostics. Methods: In total, 62 lung cancer patients (NSCLC and SCLC) were screened for CTCs in a single device application. In parallel, blood samples were analyzed with the CellSearch system. CTC enumeration was conducted by immunofluorescence microscopy using both technologies. In a second set of patients CTC enumeration and molecular characterization using the GILUPI CellCollector is conducted. The downstream diagnostic of isolated CTCs is performed by immunofluorescence microscopy with specific antibodies (ALK, PD-L1) and different molecular diagnostic assays (EGFR, KRAS) like digital PCR, qRT-PCR and sequencing. Results: The successful isolation of CTCs was significantly more frequent with the GILUPI CellCollector (73%) compared to CellSearch (29%). In the second set of patients EGFR and KRAS mutations could be detected after previous immunofluorescence microscopy. Preliminary data of the ALK and PD-L1 investigation showed the possible detection of ALK and PD-L1. Conclusions: The GILUPI CellCollector overcomes blood volume limitations of other diagnostic approaches and increases the diagnostic sensitivity of CTC isolation. It allows CTC enumeration and molecular characterization which could help guiding treatment strategies, monitoring therapy efficacy and resistance development.
"Goalpost Fever"
Authors: HENRY W. MURRAY
Journal: Annals of Internal Medicine (1975)

Letters1 July 1975"Goalpost Fever"HENRY W. MURRAY, M.D., JOHN J. MANN, M.D.HENRY W. MURRAY, M.D.Search for more papers by this author, JOHN J. MANN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-1-84 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlthough certain fever patterns have been associated with specific disease entities (that is, the double quotidian fever of gonococcal endocarditis), their diagnostic usefulness is usually limited (1). We would like to call attention to a fever pattern, the "goalpost fever" (see Figure 1), associatedwith drug reactions. The pattern is characterized by a fever spike on admission to the hospital and again 5 to 7 days later. In between, the temperature is quite normal.A 48-year-old woman with renal stones and recurrent urinary tract infections was admitted because of intermittent fever and chills. Three weeks before admission the patient was...Reference1. TUMULTYMANN PJ: The problem of fever of obscure origin, in The Principles and Practice of Medicine, 18th ed., edited by HARVEY AM, JOHNS RJ, OWENS AH, ROSS RS. New York, Appelton-Century-Crofts, 1972, ch. 92 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Medicine The Johns Hopkins Hospital Baltimore, Maryland 21205 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited BySouthwestern Internal Medicine Conference: Drug Fever: Mechanisms, Maxims and MisconceptionsDrug Fever: A Critical Appraisal of Conventional Concepts An Analysis of 51 Episodes in Two Dallas Hospitals and 97 Episodes Reported in the English LiteraturePHILIP A. MACKOWIAK, M.D., CHARLES F. LeMAISTRE, M.D.Other Antibacterial Drugs 1 July 1975Volume 83, Issue 1Page: 84-85KeywordsDrugsEndocarditisFeversKidney stonesTemperature Issue Published: 1 July 1975 PDF DownloadLoading ...
A reconsideration of the Kety and associates study of genetic factors in the transmission of schizophrenia
Authors: L S Benjamin
Journal: American Journal of Psychiatry (1976)

The author reviews a study by Kety and associates that reported a significantly greater prevalence of schizophrenic spectrum disorders among the biological relatives of schizophrenic adoptees than among those of nonschizophrenic adoptees. The principal statistical analysis of the Kety study used an incorrect sample size (306 rather than 66) and failed to weight each index and control case (family) equally. This violation of the independence assumption would allow a few families to disproportionately influence the outcome. The author argues that proper statistical analysis applied separately to available categories indicates that significant differences between the index and control groups occurred mainly in the half-sibling category; this result violates the principle that genetic effects increase with greater consanguinity. She concludes that Kety and associates' study raises more questions than it answers regarding the role of genetic factors in schizophrenia.
A Handshake
Authors: Kenneth J. Woodside
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
&lt;emph type="ital"&gt;Morning News&lt;/emph&gt;
Authors: Thomas B. Cole
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Long Term Outcomes Of Imatinib In Chronic Myeloid Leukemia In Saudi Population, Single Center Study
Authors: Enaam Mohammed Alsobhi, Mohammed m Abrar, Mohammed A Abdelaal, Ahmad S. Alsaeed, Ahmed Al-Absi, Zaid A Zahrani, Ashraf A Warsi, Abdulfattah Al-Amri, Ihab El-Hemaidi
Journal: Blood (2013)
Hepatitis A outbreak among MSM linked to casual sex and gay saunas in Copenhagen, Denmark
Authors: A Mazick, M Howitz, S Rex, I  P Jensen, N Weis, T L Katzenstein, J Haff, K Mølbak
Journal: Eurosurveillance (2005)

During an outbreak of hepatitis A predominantly among men who have sex with men (MSM) in Copenhagen, Denmark, in 2004, we did a case-control study to determine risk factors for infection. A case was an MSM &amp;gt;17 years, living in Copenhagen, with IgM positive hepatitis A infection diagnosed between June and August 2004, and without a household contact with a hepatitis A case before onset of illness. Controls were selected at the Copenhagen Pride Festival. The study included 18 cases and 64 controls. Sixteen of 18 cases and 36/63 controls had sex with casual partners (ORMH 5.6, 95% CI 1.2-26.9). Eleven of 18 cases and 14/62 controls had sex in gay saunas (ORMH 4.2, 95% CI 1.5-11.5). Sex at private homes appeared to be protective (ORMH 0.2, 95% CI 0.1-0.7). Casual sex including sex in gay saunas was an important risk factor for the spread of HAV among MSM in Copenhagen. The results are in accordance with findings in other European outbreaks. As the general immunity to hepatitis A decreases and the outbreak potential increases, we recommend health education and hepatitis A vaccination to all MSM not living in monogamous relationships, especially if they visit gay saunas or other places with frequent partner change. To stop spread of hepatitis A among MSM in Europe, a European consensus on prevention and control measures may be required.
Zika virus infections in three travellers returning from South America and the Caribbean respectively, to Montpellier, France, December 2015 to January 2016
Authors: Alexandre Thibault Maria, Marianne Maquart, Alain Makinson, Olivier Flusin, Michel Segondy, Isabelle Leparc-Goffart, Vincent Le Moing, Vincent Foulongne
Journal: Eurosurveillance (2016)

We report three unrelated cases of Zika virus infection in patients returning from Martinique, Brazil and Colombia respectively, to Montpellier, France. They developed symptoms compatible with a mosquito-borne disease, and serological and molecular investigations indicated a recent Zika virus infection. Considering the recent warning for the likely teratogenicity of Zika virus and the presence of competent mosquito vectors in southern France, these cases highlight the need for awareness of physicians and laboratories in Europe.
Prospective study of neuroleptic-induced dystonia in mania and schizophrenia
Authors: R Khanna, A Das, S S Damodaran
Journal: American Journal of Psychiatry (1992)

The authors' goal was to conduct a prospective study comparing the rate of occurrence of neuroleptic-induced dystonia in a group of consecutively admitted manic and schizophrenic patients receiving typical inpatient treatment from several clinicians.All patients met the following criteria: 1) male sex, 2) age between 17 and 45 years, 3) definite diagnosis of mania or schizophrenia according to Research Diagnostic Criteria, 4) no exposure to neuroleptics during the past month, 5) absence of past or family history of a neurodegenerative disorder with extrapyramidal symptoms. All treatment decisions were left to the treating clinicians. Fifty patients with mania and 33 with schizophrenia were included in the study. Most of these patients received high-potency neuroleptics, but the specific neuroleptic used varied in the two groups.Twelve (24%) of the patients with mania and five (15%) of the patients with schizophrenia developed acute dystonia. Manic patients received significantly higher peak doses of neuroleptics during the risk period for dystonia. Stepwise multiple regression analysis revealed that the peak neuroleptic dose and age were most strongly related to the occurrence of dystonia.This prospective study failed to support the retrospective finding of another study that acute dystonia occurred more often in manic patients than in patients with nonparanoid schizophrenia. The authors conclude that there is a need for carefully controlled prospective studies with larger groups of patients.
Broadcast of star's colonoscopy boosts screening
Authors: Roger Dobson
Journal: BMJ (2002)

A US television celebrity whose colonoscopy was shown live on television is being credited for a near 20% rise in the number of people having the procedure.

Doctors who tracked the number of colonoscopies in the months after the screening say the increase shows the power of celebrities, and they suggest that more research be carried out on using stars to promote public health messages.

The research, reported at the annual conference of the Society of General Internal Medicine in Atlanta on 3 May, looked at the after effects of a five day campaign to raise awareness of colon cancer that featured Katie Couric, co-host of NBC's Today Show. Couric's husband, Jay Monahan, died from colon cancer at the age of 42.

The cornerstone of the campaign featured her having a live, on-air colonoscopy. To quantify the effects of the campaign, the University of Michigan researchers examined colonoscopy rates drawn from a database of 400 endoscopists across the United States and from a managed care organisation from 89 weeks before the procedure to 40 weeks after it.

The data showed that the average number of colonoscopies performed by each doctor increased from 4.76 to 6.13 a week.
Histopathology of Induced Precancerous Lesions of the Small Intestine of Mice
Authors: Harold L. Stewart, M. D., Egon Lorenz, Ph. D.
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Histopathology of Induced Precancerous Lesions of the Small Intestine of Mice Get access Harold L. Stewart, M. D., Harold L. Stewart, M. D. National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Egon Lorenz, Ph. D. Egon Lorenz, Ph. D. National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 239–268, https://doi.org/10.1093/jnci/7.4.239 Published: 01 February 1947 Article history Received: 10 December 1946 Published: 01 February 1947
Case 27-1964
Authors: Walther T. Weylman, Benjamin Castleman
Journal: New England Journal of Medicine (1964)

Presentation of Case First admission. A thirty-eight-year-old business executive entered the hospital because of epigastric pain.For many years he had experienced bouts of postprandial epigastric distress. Two months before admission the episodes became more frequent, with radiation of the pain to the back. Eight years and again six years before entry a kidney stone had been passed. For several years he had had diffuse precordial pain that occurred chiefly in the evening. He habitually worked a twelve-hour day, smoked three packages of cigarettes and drank ten cups of coffee daily and consumed eight ounces of whiskey before dinner . . .
Touched
Authors: Stewart Babbott
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Studies of the Epidemiology of Staphylococcal Infection
Authors: George F. Thornton, F. Robert Fekety, Leighton E. Cluff
Journal: New England Journal of Medicine (1964)

STAPHYLOCOCCAL infections acquired by patients in the Johns Hopkins Hospital have been surveyed since 1957. Observations during this period have been almost continuous and were interrupted only for short periods because of changes in personnel. In the first year of the survey it appeared that there might be a seasonal variation in at least some types of staphylococcal infections.1 The period for which meaningful data had been collected, however, was initially too brief to be interpreted. In 1959 the greatest number of staphylococcal infections developed during the months of January and February; this variation in rate was due entirely to . . .
Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies
Authors: JL Merlin, A Guerci, S Marchal, N Missoum, C Ramacci, JC Humbert, T Tsuruo, O Guerci
Journal: Blood (1994)