tbuckley/cabot-search huggingface dataset:
TCT-783 Angiosome-target single-vessel angioplasty is not inferior to multi-vessel angioplasty in patients
Authors: Cheol Hyun Lee, Osung Kwon, Ungjeong Do, Jung Ae Hong, Kyusup Lee, Min Soo Cho, B.A.E. JAESEOK, Do-yoon Kang, Se Hun Kang, Pil Hyung Lee, Sung-Han Yoon, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2016)
Assessment of Circulating t(14;18)-Positive Cells in 4152 Individuals without Lymphoma Shows Association with Age and Gender, but Not with Smoking Status: Results From the Population-Based Study of Health in Pomerania (SHIP).
Authors: Carsten Hirt, Kerstin Weitmann, Frank Schueler, Christian Späth, Wolfgang Hoffmann, Gottfried Doelken
Journal: Blood (2009)
Oral dextrose gel may cut incidence of neonatal hypoglycaemia
Authors: Jacqui Wise
Journal: BMJ (2016)

Rubbing dextrose gel inside a newborn baby’s mouth may lower the risk of neonatal hypoglycaemia, a randomised study in PLOS Medicine has found.1

Neonatal hypoglycaemia occurs most frequently in the first 24 hours after birth. It affects as many as 15% of newborn babies and can raise a baby’s risk of brain damage or developmental delay. Babies at the highest risk are born to mothers with diabetes or are delivered preterm or with a small or large …
TCT-81 Clinical and hemodynamic results after direct transcatheter aortic valve replacement versus pre-implantation balloon aortic valvuloplasty. A case-matched analysis
Authors: Luis Nombela Franco, Carlos Ferrera, Eulogio Garcia, Pilar Jimenez, Corina Biagioni, Nieves Gonzalo, Ivan Nuñez-Gil, Ana Viana, Pablo Salinas, Javier Escaned, Antonio Fernandez-Ortiz, Carlos Macaya
Journal: Journal of the American College of Cardiology (2016)
A Profile of 648 Signaling Network Events Identifies Cell Subsets with Diverse, Abnormal Responses to Lymphocyte Stimuli within Follicular Lymphoma Tumors.
Authors: Jonathan M. Irish, Faye Y. Hsu, Jeff P. Sharman, Roch Houot, Joshua D. Brody, Debra K. Czerwinski, Garry P. Nolan, Ronald Levy
Journal: Blood (2007)
TCT-140 Explore trial (additional early CTO PCI in STEMI patients with a concurrent CTO) and SYNTAX score. What are lessons learned?
Authors: Ivo M. van Dongen, Joelle Elias, Hector M. Garcia-Garcia, Loes P. Hoebers, Dagmar M. Ouweneel, Bimmer EPM. Claessen, Jose PS. Henriques
Journal: Journal of the American College of Cardiology (2016)
Anayisis of Chromosomal Alterations by Array-Based Comparative Genomic Hybridization in 25 Patients with Sézary Syndrome.
Authors: Giorgia Saporiti, Laura Corti, Francesco Onida, Daniele Fanoni, Luigia Venegoni, Elisabetta Caprini, Cristina Cristofoletti, Giandomenico Russo, Agostino Cortelezzi, Emilio Berti
Journal: Blood (2012)
TCT-719 Volume-Outcome Relationships for Transcatheter Aortic Valve Replacement- Risk-adjusted and Volume Stratified Analysis of TAVR outcomes
Authors: Divya Ratan Verma, Mohamad Lazkani, Yash Pershad, H Kenith Fang, Ashish Pershad, Michael Morris
Journal: Journal of the American College of Cardiology (2016)
JQ1, a Selective Bromodomain Inhibitor, Augment the Immunogenicity of Mantle Cell Lymphoma By Influencing the Expression of PD-L1
Authors: Hongwei Wang, Fengdong Cheng, Jie Cheng, Alejandro Villagra, Jianguo Tao, James E. Bradner, Eduardo M. Sotomayor
Journal: Blood (2015)
TCT-501 Ultrasound examination of the forearm arteries morphology and anomalies in patients undergoing percutaneous coronary intervention via radial access.
Authors: Michal Plewka, Jan P. Peruga, Jan Z. Peruga, Karina Wierzbowska-Drabik, Jaroslaw Kasprzak
Journal: Journal of the American College of Cardiology (2016)
TCT-395 Comparison of Clinical Outcomes after Treatment of In-Stent Restenosis Using Drug-Eluting Balloon versus Newer Generation Drug-Eluting Stents: Patient-Level Pooled Analysis of Korean Multicenter In-Stent Restenosis Registry
Authors: Tae-Min Rhee, Joo Myung Lee, Joo-Yong Hahn, Doyeon Hwang, Jonghanne Park, Kyung Woo (KW) Park, Hack-Lyoung Kim, Sang-Hyun Kim, In Ho Chae, Joon-Hyung Doh, KI-HYUN JEON, Young Jin Choi, Jin Sik Park, Seung-Hyuck Choi, Hyeon-Cheol Gwon, Bon-Kwon Koo, Fernando Alfonso, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2016)
TCT-327 Prevalence, Management, and Outcomes of Atrial Fibrillation Among Patients Undergoing Percutaneous Coronary Intervention with Drug-eluting Stents
Authors: Duk-Woo Park, Se Hun Kang, Hyoin Choi, Jung-Min Ahn, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2016)
PS01.15: Outcomes after the Decision to Biopsy: Results from a Nurse Practitioner Run Multidisciplinary Lung Cancer Screening Program
Authors: Christopher R. Gilbert, Joelle T. Fathi, Candice L. Wilshire, Brian Louie, Ralph W. Aye, Alexander S. Farivar, Eric Vallieres, Jed A. Gorden
Journal: Journal of Thoracic Oncology (2016)
JAK1/JAK2 Inhibitor, Ruxolitinib Inhibits Cell Proliferation and Induces Apoptosis in Hodgkin Lymphomas (HL) and Primary Mediastinal B-Cell Lymphomas (PMBL)
Authors: Changhong Yin, Sanghoon Lee, Janet Ayello, Carmella van de Ven, James Pao, Erin Mulvey, Mitchell S. Cairo
Journal: Blood (2012)
TCT-179 Are there STEMI patients in whom manual thrombus aspiration is superior compared to standard primary PCI? Subanalysis of PATA STEMI trial
Authors: None User, Miodrag Ostojic, Branko Beleslin, Sinisa Stojkovic, Milan Nedeljkovic, Milorad Tesic, Purnachandra Rao Kondru, Yimin zhang, Milika Asanin
Journal: Journal of the American College of Cardiology (2016)
TCT-430 Baseline and procedural characteristics in the Amsterdam Investigator-initiateD randomized Absorb Trial
Authors: Joanna Wykrzykowska, Robin Kraak, Joelle Elias, Ivo van Dongen, Sjoerd H. Hofma, Rene van der Schaaf, Karin Arkenbout, Alexander Ijsselmuiden, Karel Koch, Jan Baan, Marije Vis, Jan Tijssen, Jan Piek, Robert de Winter, Jose PS. Henriques
Journal: Journal of the American College of Cardiology (2016)
Margaret McCartney: Long live generics!
Authors: Margaret McCartney
Journal: BMJ (2016)

GlasgowGenerics are good!Generics are great!Cheaper than branded preparations, generic drugs have saved the NHS huge amounts-but for how much longer?Bacterial conjunctivitis has two main treatments.Chloramphenicol costs less than £2: the jury's still out, but it may be associated with rare side effects. 1
“CUSP OVERLAP” VIEW FACILITATES ACCURATE FLUORO-GUIDED IMPLANTATION OF SELF-EXPANDING VALVE IN TAVR
Authors: Anoshia Raza, Syed Zaid, Iassen Michev, Hasan Ahmad, Ryan Kaple, Cenap Undemir, Angelica Poniros, Alexis Kearns, Joanne Bennett, Cheng Feng, Tanya Dutta, Amar Shah, Anthony Gilet, Martin Cohen, Steven Lansman, Gilbert Tang
Journal: Journal of the American College of Cardiology (2017)
TCT-420 Incidence of side branch occlusions following bioresorbable scaffold implantation for long left anterior descending artery lesions
Authors: Akihito Tanaka, Azeem Latib, Richard Jabbour, Hiroyoshi Kawamoto, Antonio Mangieri, Damiano Regazzoli, Marco Ancona, Francesco Giannini, Lorenzo Azzalini, Alaide Chieffo, Mauro Carlino, Matteo Montorfano, Antonio Colombo
Journal: Journal of the American College of Cardiology (2016)
Beta‐blockers improve survival outcomes in patients with multiple myeloma: a retrospective evaluation
Authors: Yi L. Hwa, Qian Shi, Shaji K. Kumar, Martha Q. Lacy, Morie A. Gertz, Prashant Kapoor, Francis K. Buadi, Nelson Leung, David Dingli, Ronald S. Go, Suzanne R. Hayman, Wilson I. Gonsalves, Stephen Russell, John A. Lust, Yi Lin, S. Vincent Rajkumar, Angela Dispenzieri
Journal: American Journal of Hematology (2016)

A preclinical study demonstrated anti-proliferative and apoptotic effect of propranolol on multiple myeloma (MM) cell. Clinical studies suggested that beta-blocker (BB) might impact the prognosis of breast, prostate, colorectal, ovarian, lung, and skin cancer. This retrospective study evaluated the effect of BB in MM disease-specific survival (DSS) and overall survival (OS). Among 1,971 newly diagnosed MM patients seen at Mayo Clinic between 1995 and 2010, usage of BB and other cardiac (or antihypertensive) medications were abstracted. Cumulative incidence function and Kaplan-Meier method were used to estimate 5-year cumulative incidence rate (CIR) of MM death and OS rate, respectively. Nine hundred and thirty (47.2%) patients had no intake of cardiac medications; 260 (13.2%) used BB alone; 343 (17.4%) used both BB/non-BB cardiac medications; and 438 (22.2%) had non-BB cardiac drugs. Superior MM DSS was observed in BB only users, compared to patients without any cardiac drugs ( HRadj.CS, 0.53, 95% confidence interval [CI], 0.42-0.67, Padj. <0.0001) and non-BB cardiac drugs users ( HRadj.CS, 0.49, 95% CI, 0.38-0.63, Padj. <0.0001). Patients on both BB and other cardiac drugs showed superior DSS than non-cardiac drugs users ( HRadj.CS, 0.54, 95% CI, 0.44-0.67, Padj. <0.0001) and non-BB cardiac drug users. ( HRadj.CS, 0.50, 95% CI, 0.40-0.62, Padj. <0.0001). MM DSS did not differ between BB users with and without other cardiac drugs (Padj. =0.90). Multivariable analysis showed the same pattern for OS. In patients with MM, BB intake is associated with a reduced risk of disease-specific death and overall mortality in comparison to non-BB or no use of cardiac drugs. Am. J. Hematol. 92:50-55, 2017. © 2016 Wiley Periodicals, Inc.
Why CAPS criteria are not diagnostic criteria?
Authors: Robert BM Landewé, Désirée MFM van der Heijde
Journal: Annals of the Rheumatic Diseases (2016)

Kuemmerle-Deschner et al 1 have recently published diagnostic criteria for cryopyrin-associated periodic syndrome (CAPS).

CAPS encompasses a group of very rare disorders with incompletely understood pathogenesis and diverse clinical presentations. The authors justify their efforts by claiming that there is a significant delay in diagnosis, which, in their opinion, is due to the lack of recognition and clear diagnostic criteria.

While the authors should be commended for their rigorous work, they may have overlooked the fact that they have developed classification criteria rather than diagnostic criteria. Recently, Aggarwall et al 2 have pointed out the fundamental concerns related to diagnostic criteria in rheumatology. …
TCT-574 Serial change of side branch ostial areas after single crossover stenting with kissing balloon dilatation assessed by three-dimensional Optical Coherence Tomography
Authors: Tatsuhiro Fujimura, Takayuki Okamura, Jyutaro Yamada, Tetsuro Oda, Mamoru Mochizuki, Hiroki Tateishi, Shigehiko Nishimura, Abdul Mozid, Masafumi Yano
Journal: Journal of the American College of Cardiology (2016)
TCT-596 In-Stent Neoatherosclerosis and Tissue Characteristics of Restenotic Lesions Following Implantation of Second Generation Drug-Eluting Stents in Unrestricted Coronary Lesions: Optical Frequency Domain Imaging study
Authors: Mahmoud Sabbah, Kazushige Kadota, Azza Eraki, Hanan Kamal, Ahmed El Hawary
Journal: Journal of the American College of Cardiology (2016)
Increased incidence of syphilis in men who have sex with men and risk management strategies, Germany, 2015
Authors: Klaus Jansen, Axel J. Schmidt, Jochen Drewes, Viviane Bremer, Ulrich Marcus
Journal: Eurosurveillance (2016)

In Germany, the number of reported syphilis cases increased between 11% and 22% per year between 2010 and 2014. We analysed syphilis surveillance data and data of four behavioural surveys on men who have sex with men (MSM) in Germany (2003, 2007, 2010, 2013) to assess if this rise is ongoing and to find possible explanations for it. Syphilis notifications increased in 2015 by 19% to a total of 6,834. This was mainly due to increasing notifications in MSM of all age groups in larger German cities. Data from the behavioural surveys on MSM in Germany showed a simultaneous increase of selective condom use as HIV-status-bases risk management strategy and the number of syphilis cases. MSM diagnosed with HIV reported condomless anal intercourse with non-steady partners more frequent than MSM not diagnosed with HIV or untested for HIV, but the latter also reported higher frequencies of this behaviour in the more recent surveys. Transmission in HIV-positive MSM probably plays an important, but not exclusive role, for the syphilis dynamics in Germany. A risk adapted routine screening for sexually active MSM and potentially innovative approaches to increase early screening and treatment of syphilis such as internet counselling, home sampling, home testing and broadening venue-based (rapid) testing, should be critically evaluated to effectively reduce syphilis infections.
The Timing of Reoperation for Incidental Gallbladder Cancer
Authors: Vatche G. Agopian, Jonathan R. Hiatt
Journal: JAMA Surgery (2016)

Incidental gallbladder cancer is reported in approximately 0.7% of patients undergoing a cholecystectomy.1 While the need for surgical re-resection and staging portal lymphadenectomy in the absence of metastatic disease is not debated,2 the optimal timing of reoperation is unknown.
Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis
Authors: Hao Gu, Chiqi Chen, Xiaoxin Hao, Conghui Wang, Xiaocui Zhang, Zhen Li, Hongfang Shao, Hongxiang Zeng, Zhuo Yu, Li Xie, Fangzhen Xia, Feifei Zhang, Xiaoye Liu, Yaping Zhang, Haishan Jiang, Jun Zhu, Jiangbo Wan, Chun Wang, Wei Weng, Jingjing Xie, Minfang Tao, Cheng Cheng Zhang, Junling Liu, Guo-Qiang Chen, Junke Zheng
Journal: Journal of Clinical Investigation (2016)

Certain secretory proteins are known to be critical for maintaining the stemness of stem cells through autocrine signaling. However, the processes underlying the biogenesis, maturation, and secretion of these proteins remain largely unknown. Here we demonstrate that many secretory proteins produced by hematopoietic stem cells (HSCs) undergo exosomal maturation and release that is controlled by vacuolar protein sorting protein 33b (VPS33B). Deletion of VPS33B in either mouse or human HSCs resulted in impaired exosome maturation and secretion as well as loss of stemness. Additionally, VPS33B deficiency led to a dramatic delay in leukemogenesis. Exosomes purified from either conditioned medium or human plasma could partially rescue the defects of HSCs and leukemia-initiating cells (LICs). VPS33B co-existed in exosomes with GDI2, VPS16B, FLOT1, and other known exosome markers. Mechanistically, VPS33B interacted with the GDI2/RAB11A/RAB27A pathway to regulate the trafficking of secretory proteins as exosomes. These findings reveal an essential role for VPS33B in exosome pathways in HSCs and LICs. Moreover, they shed light on the understanding of vesicle trafficking in other stem cells and on the development of improved strategies for cancer treatment.
Efficacy of Topical Sirolimus (Rapamycin) for the Treatment of Microcystic Lymphatic Malformations
Authors: Marta Ivars, Pedro Redondo
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Circulating Plasma Extracellular Microvesicle MicroRNA Cargo and Endothelial Dysfunction in Children with Obstructive Sleep Apnea
Authors: Abdelnaby Khalyfa, Leila Kheirandish-Gozal, Ahamed A. Khalyfa, Mona F. Philby, María Luz Alonso-Álvarez, Meelad Mohammadi, Rakesh Bhattacharjee, Joaquin Terán-Santos, Lei Huang, Jorge Andrade, David Gozal
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Rationale: Obese children are at increased risk for developing obstructive sleep apnea (OSA), and both of these conditions are associated with an increased risk for endothelial dysfunction (ED) in children, an early risk factor for atherosclerosis and cardiovascular disease. Although weight loss and treatment of OSA by adenotonsillectomy improve endothelial function, not every obese child or child with OSA develops ED. Exosomes are circulating extracellular vesicles containing functional mRNA and microRNA (miRNA) that can be delivered to other cells, such as endothelial cells.Objectives: To investigate whether circulating exosomal miRNAs of children with OSA differentiate based on endothelial functional status.Methods: Obese children (body mass index z score >1.65) and nonobese children were recruited and underwent polysomnographic testing (PSG), and fasting endothelial function measurements and blood draws in the morning after PSG. Plasma exosomes were isolated from all subjects. Isolated exosomes were then incubated with confluent endothelial cell monolayer cultures. Electric cell-substrate impedance sensing systems were used to determine the ability of exosomes to disrupt the intercellular barrier formed by confluent endothelial cells. In addition, immunofluorescent assessments of zonula occludens-1 tight junction protein cellular distribution were conducted to examine endothelial barrier dysfunction. miRNA and mRNA arrays were also applied to exosomes and endothelial cells, and miRNA inhibitors and mimics were transfected for mechanistic assays.Measurements and Main Results: Plasma exosomes isolated from either obese children or nonobese children with OSA were primarily derived from endothelial cell sources and recapitulated ED, or its absence, in naive human endothelial cells and also in vivo when injected into mice. Microarrays identified a restricted signature of exosomal miRNAs that readily distinguished ED from normal endothelial function. Among the miRNAs, expression of exosomal miRNA-630 was reduced in children with ED and normalized after therapy along with restoration of endothelial function. Conversely, transfection of exosomes from subjects without ED with an miRNA-630 inhibitor induces the ED functional phenotype. Gene target discovery experiments further revealed that miRNA-630 regulates 416 gene targets in endothelial cells that include the Nrf2, AMP kinase, and tight junction pathways.Conclusions: These observations elucidate a novel role of exosomal miRNA-360 as a putative key mediator of vascular function and cardiovascular disease risk in children with underlying OSA and/or obesity, and identify therapeutic targets.
Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (ABSORB II): a 3 year, randomised, controlled, single-blind, multicentre clinical trial
Authors: Patrick W Serruys, Bernard Chevalier, Yohei Sotomi, Angel Cequier, Didier Carrié, Jan J Piek, Ad J Van Boven, Marcello Dominici, Dariusz Dudek, Dougal McClean, Steffen Helqvist, Michael Haude, Sebastian Reith, Manuel de Sousa Almeida, Gianluca Campo, Andrés Iñiguez, Manel Sabaté, Stephan Windecker, Yoshinobu Onuma
Journal: The Lancet (2016)
TCT-273 Predictors of successful Stingray-assisted antegrade dissection reentry: data from the Progress CTO registry
Authors: Catalin Toma, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, David Kandzari, Nicholas Lembo, William Lombardi, J. Aaron Grantham, R. Michael Wyman, Anthony Doing, Mitul Patel, John Bahadorani, Jeffrey Moses, Ajay Kirtane, Ziad Ali, Barbara Anna Danek, Judit Karacsonyi, Bavana Rangan, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2016)
Prediction of 30-Day All-Cause Readmissions in Patients Hospitalized for Heart Failure
Authors: Jarrod D. Frizzell, Li Liang, Phillip J. Schulte, Clyde W. Yancy, Paul A. Heidenreich, Adrian F. Hernandez, Deepak L. Bhatt, Gregg C. Fonarow, Warren K. Laskey
Journal: JAMA Cardiology (2016)

Several attempts have been made at developing models to predict 30-day readmissions in patients with heart failure, but none have sufficient discriminatory capacity for clinical use. Machine-learning (ML) algorithms represent a novel approach and may have potential advantages over traditional statistical modeling.To develop models using a ML approach to predict all-cause readmissions 30 days after discharge from a heart failure hospitalization and to compare ML model performance with models developed using "conventional" statistically based methods.Models were developed using ML algorithms, specifically, a tree-augmented naive Bayesian network, a random forest algorithm, and a gradient-boosted model and compared with traditional statistical methods using 2 independently derived logistic regression models (a de novo model and an a priori model developed using electronic health records) and a least absolute shrinkage and selection operator method. The study sample was randomly divided into training (70%) and validation (30%) sets to develop and test model performance. This was a registry-based study, and the study sample was obtained by linking patients from the Get With the Guidelines Heart Failure registry with Medicare data. After applying appropriate inclusion and exclusion criteria, 56 477 patients were included in our analysis. The study was conducted between January 4, 2005, and December 1, 2010, and analysis of the data was conducted between November 25, 2014, and June 30, 2016.C statistics were used for comparison of discriminatory capacity across models in the validation sample.The overall 30-day rehospitalization rate was 21.2% (11 959 of 56 477 patients). For the tree-augmented naive Bayesian network, random forest, gradient-boosted, logistic regression, and least absolute shrinkage and selection operator models, C statistics for the validation sets were similar: 0.618, 0.607, 0.614, 0.624, and 0.618, respectively. Applying the previously validated electronic health records model to our study sample yielded a C statistic of 0.589 for the validation set.Use of a number of ML algorithms did not improve prediction of 30-day heart failure readmissions compared with more traditional prediction models. Although there will likely be further applications of ML approaches in prognostic modeling, our study fits within the literature of limited predictive ability for heart failure readmissions.