tbuckley/cabot-search huggingface dataset:
PARE0009 Estonian Youth Awareness of Invisible Chronic Diseases
Authors: L. Kullamaa
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Chronic conditions affect people all over the world; over 100 million citizens or 40% of the population in Europe above the age of 15 is reported to have a chronic disease [1]. One of the main tasks of patient organisations is to raise awareness of them. So far, there have not been any studies conducted in Estonia that would show how successful they have been in raising awareness in the general population and among the youth in Estonia. <h3>Objectives</h3> The objective of the study was to find out how aware are 15–35 years old Estonians of chronic diseases, and furthermore, through which channels they first learned about the diseases. <h3>Methods</h3> The study focused on the five most prevalent disease groups, out of which were selected specific diagnoses: juvenile idiopathic arthritis, diabetes mellitus, asthma, depression and chronic hypertension. The criteria for choosing the diagnoses were the following: diagnoses that have the most effect on young people are most prevalent or have the highest incidence rate. The data was collected via an online survey, which was spread on different social networks and among the pupils of two secondary schools. <h3>Results</h3> In total there were 191 responses from which 172 answers could be used. The average age of the respondents is 20 years. Most of them have heard about asthma (89.5%), diabetes mellitus (89.0%), chronic hypertension (78.0%) and depression (90.1%), but only 29.3% has heard about juvenile idiopathic arthritis. Most of the people, who answered, say that they first heard about the diseases from their family, friends or their acquaintances, 14.5% from television or radio and 13.4% from social media. <h3>Conclusions</h3> Although rheumatic and musculoskeletal diseases (RMDs) are one of the most common chronic conditions in Europe, from the results of the study it can be concluded that very few people in Estonia are aware of them. Since RMDs are not directly life-threatening like asthma or diabetes, it could be suggested that patients do not want to disclose their diagnosis to their acquaintances in fear of social stigma and discrimination. However, since this was a quantitative study, it is not possible to point out direct reasons and further qualitative research is needed. Additionally, from the results it can be concluded that the organisations for patients with RMDs should contribute more into raising awareness using the mediums of television, radio, and the internet. <h3>References</h3> European Union Health Policy Forum: Answer to DG SANCO consultation on chronic diseases. (2012). <h3>Acknowledgement</h3> The author would like to thank the following people: Ülle Kullamaa, Birgit Teemäe, Anna Edela, Eva Maria Stina Peek, Toomas Jürgenstein and Triin Ulst. <h3>Disclosure of Interest</h3> None declared
In Vivo Effects of Zoledronic Acid on Bone Remodeling.
Authors: Samantha Pozzi, Teru Hideshima, Sonia Vallet, Siddhartha Mukherjee, Shweta Chhetri, Diana Cirstea, Nileshwari Vaghela, Clare Thomas, Dilani Rosa, Hiroshi Ikeda, Yutaka Okawa, Tanyel Kiziltepe, Jesse Schoonmaker, Ernestina Schipani, Mary Bouxsein, Kenneth C. Anderson, Noopur Raje
Journal: Blood (2007)
Zebrafish Mll Depletion Model Phenocopies Mammalian Mll Depletion and Implicates MLL as Master Regulator of Novel Developmental Hematopoietic Targets.
Authors: Blaine W. Robinson, Yuanquan Song, Giuseppe Germano, Patricia Ernst, Joshua Abrams, Marion Scott, Amy Kugath, Marybeth Helfrich, J. Oriol Sunyer, Jennifer Rhodes, Rita Balice-Gordon, Carolyn A. Felix
Journal: Blood (2009)
Anti-Human T-Lymphocyte Immunoglobulin (ATG)-Induced T Regulatory Cells and Their Soluble Factors Suppress T Cell Proliferation: Potential Role in Allogeneic Stem Cell Transplantation
Authors: Katia Beider, David Naor, Valeria Voevoda, Olga Ostrovsky, Hanna Bitner, Evgenia Rosenberg, Nira Bloom, Simone Tal, Ivetta Danilesko, Avichai Shimoni, Arnon Nagler
Journal: Blood (2015)
OP0163 Mesenchymal Stem Cells Prevent Podocyte Injury in Lupus Prone Mice via Educating Macrophage into An Anti-Inflammatory Phenotype
Authors: Z. Zhang, L. Niu, X. Tang, R. Feng, G. Yao, W. Chen, W. Li, L. Sun
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Macrophage infiltration is a hallmark of severe lupus nephritis, contributing to podocyte injury. Mesenchymal stem cell (MSC) transplantation could alleviate lupus nephritis in both lupus mice and patients. However, the underlying mechanisms remain largely unknown. <h3>Objectives</h3> The study was designed to investigate the modulatory effect of MSCs on macrophage polarization and explore its role in preventing podocyte injury. <h3>Methods</h3> B6.MRL-Fas<sup>lpr</sup> (B6.<i>lpr</i>) mice were injected with umbilical cord MSCs (UCMSCs), while the control groups were administered with PBS or Fibroblasts. A 24-hour urine specimen was collected by putting mice in metabolic cages over a full 24-hour period every three weeks. 9 weeks later, all the mice were sacrificed. Histopathology scores of kidney were evaluated by hematoxylin-eosin (HE) staining. IgG and C3 deposits in glomeruli were assessed by immunofluorescence. Podocyte foot processes were observed under the transmission electron microscope. Mouse peritoneal macrophages were co-cultured with or without UCMSCs for 2 days, and further co-cultured with mouse podocytes for another 2 days. The expression of TNF-α, MCP-1, IL-1β and CD206 in macrophages and synaptopodin in podocytes were determined by real-time PCR. Flow cytometry was used to analyze podocyte apoptosis. <h3>Results</h3> UCMSCs treated B6.<i>lpr</i> mice showed lower levels of proteinuria, reduced glomerular deposition of IgG and C3, decreased renal histopathology scores and less foot process fusion. Besides, UCMSCs decreased macrophages infiltration while increased the expression of CD206 and synaptopodin in the kidney of B6.<i>lpr</i> mice. <i>In vitro</i> study demonstrated that macrophages co-cultured with UCMSCs expressed lower levels of inflammatory cytokines including TNF-α, MCP-1 and IL-1β, while higher levels of CD206. Moreover, UCMSCs treated macrophages induced less podocyte injury, with higher expression of synaptopodin and lower apoptotic rate. <h3>Conclusions</h3> UCMSCs prevented podocyte injury in lupus nephritis via educating macrophage into an anti-inflammatory phenotype, thus rescuing renal function. <h3>Disclosure of Interest</h3> None declared
Quantitative Assessment of Circulating t(14;18) Positive Cells by RQ-PCR at Diagnosis and Follow-Up Correspond to Clinical Characteristics and Predicts Time to Treatment Failure in Follicular Lymphoma.
Authors: Christiane Pott, Sebastian Boettcher, Monika Brueggemann, Thorsten Raff, Matthias Ritgen, Michael Unterhalt, Martin Dreyling, Wolfgang Hiddemann, Eva Hoster, Michael Kneba
Journal: Blood (2006)
TMIC-06GLIOMA-MEDIATED MICROGLIAL ACTIVATION PROMOTES GLIOMA PROLIFERATION AND MIGRATION: ROLES OF NA + /H+ EXCHANGER 1
Authors: Karen Carney, Wen Zhu, Lindsay Falgoust, Andrew Liu, John Kuo, Dandan Sun
Journal: Neuro-Oncology (2015)

Glioma-associated microglia and macrophages (GAMs) comprise up to 30% of the brain tumor mass, making them substantial contributors to the tumor environment. Once within the tumor niche, infiltrating GAMs are quickly converted to pro-tumorigenic phenotypes that enhance glioma growth and migration. Here we have characterized the role of Na + /H+ exchanger isoform-1 (NHE1) in the bidirectional communication between glioma cells and microglia. NHE1 protein expression was increased in tumor xenographs in both microglia and glioma cells. We found that microglia cells exposed to glioma-conditioned medium increased their NHE1 expression, as well as expression of the M1 marker iNOS and the M2 marker Arg1. This is in accordance with the mixed activation profile observed with GAMs. The levels of a panel of other candidates were also evaluated, revealing a large increase in expression of the cytokines IL6, IL10, and TGFβ as well as membrane type 1-matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase 9. Regulation of all these proteins was abolished when NHE1 protein in microglia was inhibited with the selective NHE1 inhibitor HOE642. We next looked at the communication from glioma-stimulated microglia back to glioma cells. Glioma cells were exposed to conditioned medium from glioma-stimulated microglia grown with or without the NHE1 inhibitor HOE642. Glioma cells treated with glioma/microglia conditioned medium showed increased levels of phosphylated-Akt, increased proliferation, and enhanced migration, but not if microglial NHE1 function had been blocked by HOE 642. Our results show that NHE1 plays important roles in both the activation of microglia in response to tumor-secreted signals as well as microglial production of secreted signals which stimulate tumor progression. Thus, NHE1 is a promising therapeutic target for the treatment of glioma. Funding sources include NIH grants R01NS075995 and R01NS048216, the HEADRUSH Brain Tumor Research Professorship, the Roger Loff Memorial GBM Research Fund, and Department of Neurological Surgery.
MiR-221 and MiR-222 Patterns Characterize Burkitt Lymphoma in Human and Mouse Model
Authors: Jessica Consiglio, Andrea Vecchione, Marco Galasso, Alberto Rocci, Mario Acunzo, Maria Rosaria Sapienza, Stefano Volinia, Pier Paolo Piccaluga, Rituparna De, Tiffany Talabere, Jingwen Guan, Nicola Zanesi, Carlo M. Croce, Flavia Pichiorri
Journal: Blood (2012)
Letter to the editor: Potential causes of the decreased effectiveness of the influenza A(H1N1)pdm09 strain in live attenuated influenza vaccines
Authors: Christopher S Ambrose, Helen Bright, Raburn Mallory
Journal: Eurosurveillance (2016)

Preview this article: Letter to the editor: Potential causes of the decreased effectiveness of the influenza A(H1N1)pdm09 strain in live attenuated influenza vaccines, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/21/45/eurosurv-21-30394-5-1.gif
Abnormal P-Selectin Localization During Megakaryocyte Development Determines Thrombosis in the Gata1low Model of Myelofibrosis.
Authors: Eva Zetterberg, Maria Verrucci, Fabrizio Martelli, Barbara Ghinassi, Emanuela D'Amore, Judith D. Goldberg, Anna Rita Migliaccio
Journal: Blood (2009)
SP0130 Comorbidities in Rheumatoid Arthritis: Cause or Effect?
Authors: D. Solomon
Journal: Annals of the Rheumatic Diseases (2016)

Dr. Solomon will discuss several areas in his presentation: 1. The concept of morbidities in rheumatoid arthritis; 2. Specific morbidities including cardiovascular disease, diabetes, and hyperlipidemia; and 3. Whether morbidities should be viewed as cause or effect with respect to rheumatoid arthritis. The discussion will focus on current scientific developments and how they pertain to rheumatology practice. <h3>Disclosure of Interest</h3> D. Solomon Grant/research support from: Amgen, Lilly, Pfizer, Genentech, Bristol Myers Squibb
SAT0616 Knee Isometric and Isokinetic Strength in Fallers and Non-Fallers with Rheumatoid Arthritis
Authors: C. Clarke, J. Smith, M. Yates, L. Watts, K. Graham, V. Pomeroy, T. O'Neill, A. Macgregor
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Muscular weakness is a cause of instability that has been reported to contribute to falling. Isokinetic and isometric dynamometry is a method of muscle assessment useful to measure the muscular strength and gives a quantification of the weakness and a comparison of strength across limbs and in reciprocal muscles. <h3>Objectives</h3> To compare isokinetic and isometric knee flexion and extension strength between fallers and non-fallers with Rheumatoid Arthritis (RA). <h3>Methods</h3> Sixty people with RA who gave informed consent were divided into two groups based on having a fall or not in the period of one year before evaluation, fallers (n=30, age 72.4years 15 males) and non-fallers (n=30, age 72.5 years, 16 males). Knee flexor and extensor strength was assessed using isokinetic and isometric dynamometry. Participants both limbs were tested at three fixed angular velocities isokinetically: 120°/s, 90°/s, and 60°/s and at three fixed positions isometrically, 90°, 60° and 30°. Bilateral comparison was determined by the percent deficit between left and right limbs for each participant. The ipsilateral comparison was determined between reciprocal muscles by the flexion/extension ratio. Independent t-test was used to identify significant differences between the fallers and non-fallers. The significance level was set at p&lt;0.05 <h3>Results</h3> 25 fallers and 30 non-fallers completed the isometric tests and 23 fallers and 28 non-fallers completed the isokinetic tests. In the bilateral comparison of the weaker and stronger limb in the fallers and non-fallers groups showed a large percentage deficit (range 22–43%) of isokinetic muscle strength between limbs in flexion and extension. Fallers had a significantly larger percentage deficit than non-fallers of isometric muscle strength between limbs in extension at 90° (p=0.02) and 60° (p=0.01). The ipsilateral comparison shows that the fallers had a significantly (p&lt;0.05) smaller flexion/extension ratio indicating a reduced hamstring strength at all isokinetic speeds (120°/sec F:0.73, NF:0.97, 90°/sec F:0.75, NF:0.94, 60°/sec F:0.74, NF:0.90). The fallers also had a significantly (p&lt;0.05) smaller flexion/extension ratio isometrically at 60° and 30°. <h3>Conclusions</h3> These results demonstrate both RA fallers and RA non-fallers showed a large deficit in muscle strength between limbs. RA fallers had a significantly larger limb deficit in isometric extensor strength at 90° and 60°. The RA fallers had a significantly reduced flexion/extension ratio compared to the RA non-fallers indicating an imbalance between quadriceps and hamstring strength. Addressing the weakness in one limb and the imbalance between quadriceps and hamstrings may reduce the number of falls in this population. <h3>Disclosure of Interest</h3> None declared
David Oliver: Seven day services and soundbites
Authors: David Oliver
Journal: BMJ (2016)

“Our plans for seven day services are simple,” the health secretary, Jeremy Hunt, clarified in his party’s conference speech in October.1 The Conservatives’ 2015 election manifesto pledged that hospitals would be “properly staffed, so the quality of care is the same every day of the week.”2 But detail was sketchy.

In 2014 NHS England’s Five Year Forward View had presaged this, saying, “To reduce variations in how patients receive care, we will develop a framework for how seven day services can be implemented affordably and sustainably.”3

Analysts at the Department of Health have warned …
SAT0078 Prospective Observational Study To Evaluate The Use of Musculoskeletal Ultrasonography To Improve Rheumatoid Arthritis Management: Canadian Experience (ECHO)
Authors: M. Stein, E. Rampakakis, J.S. Sampalis, W. Bensen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Musculoskeletal Ultrasound (MSUS) has been shown to be superior to clinical examination in the detection of synovitis in patients with Rheumatoid Arthritis (RA), and can be used to improve diagnostic accuracy [1] and potentially monitor disease changes in order to make treatment decisions aimed at optimizing patient care. Since the creation of the Canadian Rheumatology Ultrasonography Society (CRUS) in 2010, an increasing number of rheumatologists has been trained in the use of MSUS. <h3>Objectives</h3> The overall study objective is to compare the effectiveness of MSUS to Routine Care (RC) as a disease management tool in patients with moderate-to-severe RA for whom a change in treatment is indicated. The study also assessed the predictive power of US assessments. <h3>Methods</h3> Descriptive interim analysis of the “Echo” study, a prospective two-cohort, quasi-experimental study of patients diagnosed with active moderate-to-severe RA managed either with MSUS or as per RC. In order to be eligible for the study patients must require a change in treatment as per the judgment of the treating physician. Patients are followed for 1 year with assessments at baseline, 3, 6, 9, and 12 months. Outcome measures of interest include CDAI Remission, DAS-28 Remission and DAS-28 Low Disease Activity (LDAS). <h3>Results</h3> A total of 339 patients (70.1% female) with a mean (SD) age of 58.7 (11.79) years and disease duration of 7.4 (10.2) years were enrolled, without any significant differences between treatment groups. There were no differences between the two treatment groups with respect to the study outcomes. However, higher total US Erosion Scores at baseline were associated with lower rates of LDAS at 9 months (OR =0.810; P=0.047) and 12 months (OR =0.808; P=0.078) and lower rates of DAS-28 Remission at 9 months (OR =0.811; P=0.60); higher total synovitis GREY scale at baseline was associated with a lower rate of LDAS at 6 months (OR =0.913; P=0.014) and DAS – 28 Remission at 3 months (OR =0.911; P=0.074) <h3>Conclusions</h3> MSUS assessments can be useful predictors of future disease remission in patients with RA. The impact of MSUS on disease management and clinical outcomes requires further study. <h3>References</h3> Colebatch AN et al. Ann Rheum Dis 2013, 72:804–814. <h3>Disclosure of Interest</h3> None declared
Efficacy of 90yttrium-Ibritumomab Tiuxetan in Extranodal Marginal-Zone Lymphoma,
Authors: Anna Vanazzi, Chiara Grana, Cristiano Crosta, Giancarlo Pruneri, Stefania Rizzo, Davide Radice, Antonello Pinto, Liliana Calabrese, Mara Negri, Giovanni Paganelli, Giovanni Martinelli
Journal: Blood (2011)
Towards a Purely Oncogenetic Risk Classification of Adult T-ALL: a GRAALL Study
Authors: Amélie Trinquand, Aline Tanguy-Schmidt, Raouf Ben Abdelali, Jérôme Lambert, Etienne Lengliné, Noemie De Gunzburg, Dominique Payet-Bornet, Ludovic Lhermitte, Hossein Mossafa, Véronique Lhéritier, Françoise Huguet, Agnès Buzyn, Thibaut Leguay, Jean-Yves Cahn, Xavier Thomas, Yves Chalandon, Andre Delannoy, Caroline Bonmati, Sebastien Maury, Bertrand Nadel, Elizabeth Macintyre, Norbert Ifrah, Herve Dombret, Vahid Asnafi
Journal: Blood (2012)
Circulating Cytokine Profiles of Patients with Acquired Aplastic Anemia and Myelodysplastic Syndrome
Authors: Xingmin Feng, Phillip Scheinberg, Colin O. Wu, Leigh Samsel, Olga Nunez, Courtney Prince, Barbara Weinstein, Rebecca D Ganetzky, J. Philip McCoy, Jaroslaw P. Maciejewski, Neal S. Young
Journal: Blood (2008)
Prognostic Factors in Localized Hodgkin’s Lymphoma: How To Define Intermediate/Unfavourable Disease?.
Authors: Christian Gisselbrecht, Nicolas Mounier, Olivier Casanovas, O. Reman, Catherine Sebban, Marine Divine, Pauline Brice, Josette Briere, Christophe Hennequin, Pierre Feugier, Christophe Ferme
Journal: Blood (2004)
Danazol Increases ADAMTS13 Activity and Reduces Requirement for Therapeutic Exchange Plasmapheresis (TEP) and Plasma Infusion in Patients with TTP.
Authors: Eugene Ahn, Wenche Jy, Loreta Bidot, John Byrnes, Joaquin Jimenez, David Andrews, Sherry Shariatmadar, Yeon-Soong Ahn
Journal: Blood (2006)
Superiority of Outcome for Patients with Late-Onset EBV Viremia Post Allogeneic Stem Cell Transplantation: A Chinese Multicenter Survey
Authors: Jia Chen, Feng Chen, Yang Xu, Ying Wang, Ziling Zhu, Jing Xu, Xiaoli Li, Chunmei Ye, Xiebing Bao, Aining Sun, Wu Depei
Journal: Blood (2015)
LIM-Domain Protein Ajuba Is a Required Co-Factor for Gfi1-Induced Epigenetic Switch Regulating Runx2 Repression in Multiple Myeloma-Exposed Pre-Osteoblasts
Authors: Juraj Adamik, Jixin Ding, Wei Zhao, Peng Zhang, Quanhong Sun, G. David Roodman, Deborah Lynn Galson
Journal: Blood (2015)
The Multiple Myeloma Research Consortium Genomics Initiative.
Authors: Jeffrey Trent, John Carpten, Michael Reich, Ted Liefeld, Jonathan Keats, Spyro Mousses, William Hahn, Suzanne Trudel, David Siegel, S. Vincent Rajkumar, Melissa Alsina, Paul Richardson, Kenneth Anderson, Daniel Auclair, Louise M. Perkins, Kathy Giusti, Rafael Fonseca, Todd R. Golub
Journal: Blood (2007)
CDKN1B Encoding the Cyclin-Dependent Kinase Inhibitor 1B (p27) but Not ETV6 Is Located in the Minimally Deleted Region of 12p Abnormalities in Myeloid Malignancies and Its Expression Is Associated with Outcome in Acute Myeloid Leukemia (AML).
Authors: Claudia Haferlach, Alexander Kohlmann, Sonja Schindela, Tamara Weiss, Wolfgang Kern, Susanne Schnittger, Torsten Haferlach
Journal: Blood (2009)
One in 100 using out-of-hours primary care needs hospital care within three days
Authors: Susan Mayor
Journal: BMJ (2016)

Nearly 1% of patients who see out-of-hours primary care services need urgent admission to hospital within three days, a retrospective study of one UK service has found, and older patients, prior users, and those presenting at less busy times are most at risk.1

Out-of-hours primary care services handled around 5.9 million cases in England in 2013-14. But it can …
Evert Verhagen
Authors: Johann Windt
Journal: British Journal of Sports Medicine (2016)

![Graphic][1]</img> Pretty basic. Early start—90 min train ride to work (Vrei University)—so it is shower, gulp down of coffee and out the door by 6. Yes, I skip breakfast. Every time a PhD trainee successfully defends his or her thesis is a new equally fond memory (11 so far). That must be the first time I outran my father in a race. There was an unforgettable look on his face. A look of defeat and grudge while at the same time being proud of his little boy. My work on prevention of ankle injuries and injuries in children has contributed in a way, but a small piece of a larger puzzle. I hope to be able to contribute with a larger piece somewhere in the future. Modesty—humility, let folks find out what you have done, do not spell it out for them. It carries more weight that way. My parents always joked that they required a season pass to the emergency room with me as their son. Yet my worst injury was Osgood-Schlatter disease that forced me to give up high-level athletics at the age of 18. In 2006 I … [1]: /embed/inline-graphic-1.gif
A Unique Pre-Clinical Model Providing Access to a Drug Resistant Population within the Multiple Myeloma Stem Cell Niche in a Novel 3-D Culture System for Bone Marrow.
Authors: Julia Kirshner, Kyle J. Thulien, Lorri D. Martin, Carina Debes Marun, Tony Reiman, Andrew R. Belch, Linda M. Pilarski
Journal: Blood (2007)