tbuckley/cabot-search huggingface dataset:
Ventilation-Perfusion "Reverse Mismatch" From Aspirated Medication
Authors: J D Slavin, R M Sherigar, R P Spencer
Journal: Clinical Nuclear Medicine (1998)

A woman with acute respiratory distress had a chest radiograph that showed volume loss on the left side. A radioxenon lung scan revealed normal ventilation of the right lung and visualization of both trachea and main stem bronchi. Perfusion lung imaging showed some of the left lung to be perfused. This suggested a foreign body or mass obstructing the left main stem bronchus. An aspirated medication pill was found and removed at bronchoscopy. The left lung then became air filled.
Interhemispheric transfer deficit and alexithymia
Authors: S B Zeitlin, R D Lane, D S O'Leary, M J Schrift
Journal: American Journal of Psychiatry (1989)

The hypothesis that alexithymia reflects a functional disconnection between the two cerebral hemispheres was examined in 25 male combat veterans with posttraumatic stress disorder (PTSD). Multiple regression analysis revealed that the efficiency of interhemispheric communication, evaluated with a tactile finger localization task, was a significant predictor of the degree of alexithymia, as measured by the Toronto Alexithymia Scale, independent of PTSD severity and IQ. The PTSD subjects without alexithymia did not differ on the finger localization task from 10 male control subjects without alexithymia. These data suggest that at least some forms of alexithymia may be mediated by an interhemispheric communication deficit.
Congress Maintaines Interest in NIH Matters
Authors: B. Duane, D. A. Tisevich
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Congress Maintaines Interest in NIH Matters Get access Betsy Duane, Betsy Duane Search for other works by this author on: Oxford Academic PubMed Google Scholar Dorothy A. Tisevich Dorothy A. Tisevich Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 5, 2 March 1994, Pages 337–339, https://doi.org/10.1093/jnci/86.5.337 Published: 02 March 1994
EXERCISE ATRIAL FUNCTION ANALYSIS BY SPECKLE TRACKING IN HEART FAILURE: PATHOPHYSIOLOGICAL IMPLICATIONS ON RIGHT VENTRICULAR TO PULMONARY CIRCULATION UNCOUPLING
Authors: Greta Generati, Tadafumi Sugimoto, Francesco Bandera, Eleonora Alfonzetti, Marta Pellegrino, Marco Guazzi
Journal: Journal of the American College of Cardiology (2016)
Cardiovascular Response to Large Doses of Intravenous Morphine in Man
Authors: Edward Lowenstein, Phillips Hallowell, Frederick H. Levine, Willard M. Daggett, W. Gerald Austen, Myron B. Laver
Journal: New England Journal of Medicine (1969)

Large doses of intravenous morphine (0.5 to 3.0 mg per kilogram of body weight) were used alone or in combination with inhalation anesthetic agents for anesthesia in over 1100 patients undergoing open-heart surgery. Morphine, 1 mg per kilogram, was administered intravenously to seven subjects with aortic-valve disease and eight without major heart or lung disease. The cardiac subjects had higher control pulse rates and lower control stroke indexes than the normal subjects. In the cardiac but not in the normal subjects, significant increases in cardiac index, stroke index, central venous pressure, and pulmonary-artery pressure, and a significant decrease in systemic vascular resistance, were observed after morphine was administered, suggesting that large doses of morphine may be used with safety in patients with minimal circulatory reserve.
DIAGNOSTIC DELAYS IN TYPE B AORTIC DISSECTIONS
Authors: Thomas Goslinga, James Froehlich, Arturo Evangelista, Kevin Harris, G. Chad Hughes, Firas F. Mussa, Stuart Hutchison, Linda Pape, Mark Peterson, Udo Sechtem, Truls Myrmel, Philippe Steg, Daniel Montgomery, Christoph A. Nienaber, Eric Isselbacher, Kim Eagle, Troy LaBounty
Journal: Journal of the American College of Cardiology (2016)
Managed Care Takes Control of Prevention and Control
Authors: H. McIntosh
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Managed Care Takes Control of Prevention and Control Get access Hugh McIntosh Hugh McIntosh Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 13, 5 July 1995, Pages 955–958, https://doi.org/10.1093/jnci/87.13.955 Published: 05 July 1995
Colonoscopy and tumors
Authors: M. Bourke
Journal: Endoscopy (2012)

Colonoscopy with polypectomy reduces the lifetime risk of colorectal cancer (CRC) [2]. Accurate histological assessment of excised polyps informs two clinical pathways: surveillance recommendations, which are primarily based on the adenoma vs. hyperplastic polyp differentiation; and, less commonly, invasive disease, which requires further therapy. In routine practice the vast majority of polyps that are removed are ≤ 5 mm (diminutive polyps); only 50 % are adenomas, and advanced histology (villous component or high grade dysplasia, which are currently undetectable endoscopically) or unsuspected invasive disease is rare. Thus, the primary importance of formal histology in patients with diminutive polyps is to determine the surveillance interval, with little if any impact on immediate clinical outcomes. The advent of worldwide CRC screening programs, improved imaging technology, and the increasing focus on quality and adenoma detection will increase the frequency of diminutive polypectomy substantially and consequently the burden and cost of histological assessment for diminutive polyps. Recent data suggests that user-friendly, efficient “push button” technology, such as narrow-band imaging (NBI), can reliably distinguish adenomas from hyperplastic polyps, and consequently real-time endoscopic diagnosis (without formal histological assessment) may be a more efficient and cost-effective means of handling the pathological diagnosis and surveillance recommendations in this diminutive polyp subgroup [3] [4]. However, incorrect surveillance practice carries financial and clinical implications. Surveillance colonoscopy performed too often increases costs and the risk of adverse events, whereas surveillance colonoscopy that is performed less often than required may increase the risk of interval cancer with its associated costs.
Abstract 4104: Netrin-1 promotes the invasiveness and survival of human glioblastoma cells.
Authors: Jorma K. Keski-Oja, Irene Ylivinkka, Yizhou Hu, Tuula Nyman, Marko Hyytiainen
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme (GBM) is the most severe human brain cancer, which has no efficient treatment. The main reason for the lethality of GBM is its resistance to all current therapies and highly invasive. According to microarray data on Oncomine database netrin-1 is upregulated in glioblastoma tumors. Netrin-1 is a secreted laminin related extracellular matrix protein. Its main function is to regulate the axon guidance during embryogenesis. Recently it has been observed to act as a survival factor for different forms of cancer such as aggressive neuroblastoma, metastatic breast cancer and non small cell lung cancer. It also promotes tumorigenesis of colorectal cancer. Based on these observations we explored the possibility whether netrin-1 plays a role in human GBM. We analyzed the effects of netrin-1 expression on human GBM cells. According to Matrigel invasion assays overexpression of netrin-1 increased the invasiveness whereas partial knock-down of netrin-1 by shRNAs reduced the invasiveness of human GBM cells. On the other hand, complete knock-down of netrin-1 led to apoptotic death of those cells. To further analyze netrin-1 signaling in human GBM we performed a mass spectrometry screen to identify binding partners of netrin-1. We identified Notch as a novel receptor for netrin-1. In addition, we observed that netrin-1 overexpression increased and knockdown decreased Notch activation. The role of Notch signaling regarding the aggressiveness of various cancers has been controversial. Our results confirm that increased Notch signaling increases glioblastoma cell invasiveness, and that netrin-1 increases Notch signaling. Further, we identified here a recombinant netrin-1 fragment that inhibits Notch signaling by blocking the Notch signaling complex to the cell surface. Current studies provide new mechanistic information on the tumorigenesis of GBM. Activation of Notch signaling pathway has been linked to the initiation of EMT which is essential for cancer cell invasion. Our results suggest that netrin-1 regulates GBM invasion by activating Notch signaling. The inhibition of netrin-1 signaling may prove out to be a treatment option for human glioblastoma. Citation Format: Jorma K. Keski-Oja, Irene Ylivinkka, Yizhou Hu, Tuula Nyman, Marko Hyytiainen. Netrin-1 promotes the invasiveness and survival of human glioblastoma cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4104. doi:10.1158/1538-7445.AM2013-4104
Abstract 3734: Alcohol consumption and breast cancer risk among Nigerian women
Authors: Ningqi Hou, Temidayo O. Ogundiran, Clement A. Adebamowo, Olufunmilayo I. Olopade, Dezheng Huo
Journal: Cancer Research (2011)

Abstract Background: Alcohol consumption has been reported as a risk factor for breast cancer. However, little is known about its importance for indigenous African population, among whom the prevalence of breast cancer is relatively low. The purpose of this study was to investigate the relationship between alcohol drinking and breast cancer risk in Nigerian women. Methods: The study was based on the Nigerian Breast Cancer Study, a case-control study of breast cancer conducted in Ibadan, Nigeria, between 1998 and 2010. In-person interviews were conducted with 1355 invasive breast cancer cases and 1132 community controls, using structured questionnaires to collect detailed epidemiologic data including alcohol drinking. Multivariate logistic regression was performed to estimate odds ratios (OR) and 95% confidence intervals (CI), controlling for age, ethnicity, and type of questionnaire (we revised the questionnaire in the middle of study), with potential effect measure modifications tested. Results: 5.8% controls and 11.3% cases reported drinking alcohol every week for at least 6 months, with crude OR=2.08 (95% CI: 1.54-2.82, p&amp;lt;0.0001). After adjusting for potential confounding variables, alcohol drinking remained statistically associated with breast cancer risk but the strength of association was attenuated (adjusted OR=1.56, 95% CI: 1.11-2.19, p=0.01). Among women who drink weekly, the average drinks per week were 1.7±0.8 in controls and 3.4±5.8 in cases, and there was a dose-response trend: the crude OR was 1.86 for women who had 1-2 drinks per week and 3.27 for those who had ≥ 2 drinks per week, compared with non-drinkers (p-trend=0.08). The age- and ethnicity-adjusted ORs for 1-2 drinks and ≥ 2 drinks per week were 1.20 (95% CI: 0.49-2.93) and 1.80 (95% CI: 0.36-8.87), respectively. The association between alcohol drinking and breast cancer was particularly stronger in overweight or obese women who have BMI ≥ 25 kg/m2 (adjusted OR=1.92, 95% CI: 1.23-3.01, p=0.004) than in normal weight women (adjusted OR=1.20, 95% CI: 0.71-2.02, p=0.5). Similar association was observed in pre-menopausal and post-menopausal women. Conclusions: Our study showed that regular alcohol intake is uncommon among Nigerian women. However, regular alcohol drinking may increase breast cancer risk among the Nigerians, particularly overweight women. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3734. doi:10.1158/1538-7445.AM2011-3734
Polymorphism of Adhesion Molecule CD31 and Its Role in Acute Graft-Versus-Host Disease
Authors: Esther Behar, Nelson J. Chao, Debra D. Hiraki, Shalini Krishnaswamy, Byron W. Brown, James L. Zehnder, F. Carl Grumet
Journal: New England Journal of Medicine (1996)

Graft-versus-host disease (GVHD) caused by poorly defined minor (i.e., other than HLA) histocompatibility antigens remains a serious problem in recipients of bone marrow transplants. We sought to determine whether the CD31 adhesion molecule is a minor alloantigen.
Patients' Quality of Life Under Study In Europe
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Patients' Quality of Life Under Study In Europe Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 1, 6 January 1993, Pages 12–13, https://doi.org/10.1093/jnci/85.1.12 Published: 06 January 1993
NI-24 * IMPROVING BIOBANKED SPECIMEN QUALITY: LABEL-FREE MICROSCOPIC ASSESSMENT OF HUMAN BRAIN TUMOR BIOPSIES PRIOR TO BIOBANKING
Authors: J. Eschbacher, J. Georges, A. Zehri, M. Mooney, E. Carlson, J. Nichols, K. Farhat, T. Anderson, M. Preul, K. Jensen, P. Nakaji
Journal: Neuro-Oncology (2014)

INTRODUCTION: Biobanked brain tumor specimens share a critical shortcoming: the inability to efficiently screen tissue specimens prior to banking, potentially leading to storage of poor-quality samples. Standard histologic approaches to evaluate cellularity of tissue, such as frozen sectioning, may alter molecular characteristics and damage tissue for downstream analyses. Here, utilizing a novel ex vivo approach, we evaluate the feasibility of interrogating tissue cellularity and cytoarchitecture with label-free confocal reflectance microscopy (CRM) prior to biobanking. METHODS: Biopsies from patients with intracranial neoplasms (n = 3 for each; glioma, meningioma, pituitary adenoma, and schwannoma) were transported to the pathology department and placed in ice-cold saline. Samples were immediately positioned on the stage of our pathology-based Zeiss LSM710 confocal microscope and visualized with CRM. CRM images were evaluated for tumor cellularity, architecture and morphology, and then compared to corresponding permanent sections. RESULTS: CRM could contrast cellularity and stroma in all samples, as compared to corresponding permanent sections. Additionally, CRM contrasted vasculature and regions of necrosis in glioblastomas, tumor architecture in meningiomas and schwannomas, and sheets of neoplastic cells in pituitary ademonas. DISCUSSION: We found confocal reflectance microscopy to be a simple approach to screening biospecimens prior to biobanking. CRM quickly generated distinct ex vivo microscopic images from biopsies without tissue processing or application of exogenous dyes. CRM contrasted histopathological features present in our samples, and produced images that could be digitally stored and recalled with the matched specimen in the biobank. In our previous studies, we reported CRM did not alter the molecular integrity of fresh biopsies from brain tumor animal models. We hypothesize that wider use of this technique could improve the quality of banked tissue.
AB0183 The evaluation of clinical evaluation for disease activity of rheumatoid arthritis.
Authors: M. Mukai, M. Kanda, M. Kondo
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The activity of rheumatoid arthritis (RA) is evaluated with many clinical criteria such as DAS (disease activity score), SDAI (simplified disease activity index), CDAI (clinical disease activity), and Boolean method. With these criteria, it has become convenient to evaluate the patient's state and the efficacy of treatment for RA. However, the subjective data such as patient global assessment have sometimes no connection to the objective data. <h3>Objectives</h3> The purpose is to evaluate the each clinical scale to find the difference of clinical efficacy, and to find main factor that causes the discrepancy of the criteria from clinical state of the patients. <h3>Methods</h3> We retrospectively evaluated 421 patients with RA, who had been followed in our division in August 2012, with clinical criteria such as DAS28ESR, DAS28CRP, SDAI, CDAI, and Boolean method (trial and practice). The ratio of male to female was 83:338, and the average age was 64.4±13.5 (17.2-91.9) years old. The average follow-up periods in our division was 8.4±5.5 (0.2-29.0) years. <h3>Results</h3> Methotrexate and biologics were administered in 301 (71.5%) and 148 (35.2%) patients, respectively. Steroid was used in 164 patients (39.0%). Three hundreds twenty-seven patients (77.7%) were achieved to clinical remission with one of these criteria, whereas 103 patients (24.2%) were satisfied with all criteria for clinical remission. The ratio of clinical remission was much with DAS28CRP (67.2%), and little with Boolean trail (28.3%). Although more than 90% of patients showed low disease activity with SDAI and CDAI, only 69.3% patients were satisfied with low disease activity by DAS28ESR. The main factors not to satisfy clinical remission were patient's global assessment for all criteria, and ESR for DAS28ESR. Patient's visual analogue scales were not often reflected with their real clinical assessment by their words. As ESR was also reflected with anemia and hyper-gammaglobulinemia, it was not always useful to evaluate the inflammation of RA. The many patients with high disease activity had high score of tender joints count and patient global assessment without inflammation. <h3>Conclusions</h3> Because of the progression of treatment for RA, many patients were achieved to the clinical remission or low disease activity in real world. The patients who showed high disease activity were mainly occupied with those who had destructive joints damage without inflammation. Also, it should be very careful to judge the patients' clinical state when the clinical remission criteria would not be satisfied because of the failure due to only the subjective marker. <h3>Disclosure of Interest</h3> None Declared
A Multidisciplinary Approach to Heredofamilial Cancer Syndromes: Evaluation of the First Four Years of Experience at a Spanish University Hospital
Authors: I. Márquez-Rodas, M. Sanz, S. Luque, I. Peligros, C. Mata, M. Die-Trill, C. Flores Sanchez, S. Lizarraga, O. Bueno, S. López-Tarruella, A.J. Muñoz Martín, C. Lopez Lopez, P. Menchen, J. Gomez Camarero, J.A. Pajares, J. Solera, J.P. Justel, J.A. Arranz Arija, P. García Alfonso, M. Martin
Journal: Annals of Oncology (2014)
Double-balloon enteroscopy for the detection of diffuse small-bowel polypoid ganglioneuromatosis mimicking Crohn’s disease in a patient with von Recklinghausen disease
Authors: Serta Kilincalp, Mevlüt Hamamcı, Hakan Akinci, Şahin Çoban, Aydın Köksal, İlhami Yüksel
Journal: Endoscopy (2015)

A 51-year-old woman with an 8-month history of recurrent episodes of abdominal pain, mild bloody diarrhea, and weight loss (6 kg in 3 months) was referred to our unit for evaluation of suspected Crohn's disease. She had carried a diagnosis of type 1 neurofibromatosis for 30 years. Physical examination revealed multiple café-au-lait spots and multiple cutaneous neurofibromas. Her abdomen was mildly tender in the lower abdomen with no detectable palpable mass. Laboratory test results were as follows: hemoglobin level 9.6 g/dL, sedimentation rate 40 mm/h, C-reactive protein 23 mg/dL. Other biochemical tests were unremarkable. A colonoscopy revealed a normal-appearing colon and an edematous terminal ileum with a 1-cm pedunculated polyp covered by exudate ([Fig. 1]). A magnetic resonance enterography showed thickening of the jejunum and terminal ileum, and a pedunculated polyp, about 1 cm in diameter, located in the terminal ileum ([Fig. 2]). An oral double-balloon enteroscopy showed multiple, raspberry-like, 3 – 5-mm, sessile polyps, which were covered by faint exudates located in the proximal jejunum ([Fig. 3]). Biopsies of the polyps in the jejunum and ileum revealed intestinal ganglioneuromatosis.
Abstract 153: DNA methylation alters DNA and chromatin structure leading to genetic instability in mammals
Authors: Guliang Wang, Karen M. Vásquez
Journal: Cancer Research (2010)

Abstract Chromosomal breakpoints and translocation hotspots in human cancers are often found near sites of aberrant DNA methylation. DNA hypomethylation can lead to illegitimate recombination events and can stimulate V(D)J recombination in the immunoglobulin genes. However, this co-localization of chromosomal breakage cannot be explained by previously proposed mechanisms of CpG hypermethylation-induced genetic instability, e.g., deamination-induced point mutation, or epigenetic gene silencing, because these events should not lead directly to DNA double-strand breaks. In this study, we determined the effect of cytosine methylation on the stability of CpG-rich sequences in mammalian cells and on chromosomes in mice, without altering the global genome-wide DNA methylation status. We found that methylation of specific CpG repeats induced higher frequencies of deletions and rearrangements within and surrounding the methylated repeats than that found with unmethylated CpG repeats. In addition, we found that those mutations induced by the methylated CpG repeats had a broader size distribution than that found with unmethylated CpG repeats. In an effort to elucidate the mechanism of hypermethylation-induced genetic instability, we discovered that unusual structural features of the methylated CpG sequences precluded local nucleosome assembly, leading to an increase in mutations. Thus, we propose a novel process of DNA methylation-induced genetic instability in mammals in which methylation of CpG-rich sequences can alter both DNA and chromatin structures, leading to DNA double-strand breaks. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 153.
Ovarian-Vein Thrombosis
Authors: Philipp Wiggermann, Christian Stroszczynski
Journal: New England Journal of Medicine (2011)

Four days after uncomplicated delivery of a full-term infant, a 36-year-old woman presented to the ER with severe pain in the right flank. Her medical history included a remote deep-vein thrombosis of the leg and heterozygosity for the factor V Leiden mutation.