tbuckley/cabot-search huggingface dataset:
A Quantitative Comparison of the Antileukemic Effectiveness of Two Folic Acid Antagonists in Mice
Authors: Goldin, Abraham, Venditti, John M., Humphreys, Stewart R., Dennis, Don, Mantel, Nathan, Greenhouse, Samuel W.
Journal: JNCI Journal of the National Cancer Institute (1955)

A Quantitative Comparison of the Antileukemic Effectiveness of Two Folic Acid Antagonists in Mice Get access Abraham Goldin, Abraham Goldin Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar John M. Venditti, John M. Venditti Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Stewart R. Humphreys, Stewart R. Humphreys Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Don Dennis, Don Dennis Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nathan Mantel, Nathan Mantel Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Samuel W. Greenhouse Samuel W. Greenhouse Laboratory of Chemical Pharmacology, and Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 6, June 1955, Pages 1657–1664, https://doi.org/10.1093/jnci/15.6.1657 Published: 01 June 1955 Article history Received: 29 October 1954 Published: 01 June 1955
Abstract 3189: Prevalence of Bicuspid Aortic Valve in Turner Syndrome
Authors: Vandana Sachdev, Lea Ann Matura, Stanislav Sidenko, Vincent Ho, Andrew Arai, Douglas R Rosing, Carolyn Bondy
Journal: Circulation (2007)

Women with Turner syndrome (TS) have an increased risk of congenital cardiovascular defects. Previous studies have reported a 10 –20% prevalence rate of bicuspid aortic valves and there are increasing reports of a vasculopathy that predisposes patients to aortic dilatation and dissection. This prospective study aimed to characterize aortic valve and aortic root structure in unselected asymptomatic individuals with TS. A total of 253 females aged 7– 67 years with karyotype proven TS were examined. Transthoracic echocardiography revealed a normal tricuspid aortic valve (TAV) in 162, a ‘probable TAV’ in 8 subjects, a bicuspid aortic valve (BAV) in 65 and ‘probable BAV’ in 3 subjects. The aortic valve could not be visualized by echocardiography in 15/253 or 6%. Magnetic resonance imaging (MRI) revealed valve structure in 11/12 of the probable cases (all confirmatory of the ‘probable’ diagnosis) and 12/15 of the non-visualized cases (8 BAV and 4 TAV), so only 3/253 subjects could not be visualized by either modality. The aortic valve was bicuspid in 76 of the 250 adequately imaged subjects (30%). Peak aortic valve flow was higher in BAV subjects (1.72±0.07 vs. 1.90v0.03 m/sec, P=0.0002), with one case of significant aortic stenosis. Among subjects with a BAV, aortic regurgitation was moderate or greater in ∼15%. Aortic diameters at the annulus, sinuses of Valsalva, sinotubular junction and ascending aorta were all significantly greater in the BAV group. Thirty patients in the BAV group (12%) had aortic root diameters that were outside of the 95% normal confidence limits based on Roman nomograms. Ascending aortic diameters by echo and MRI were highly correlated (r=0.77). In summary, echocardiography supplemented with MRI reveals an extraordinarily high prevalence of abnormal aortic valves in asymptomatic subjects with TS. The abnormal valve structure is associated with higher peak flows, evidence of clinically significant valvular dysfunction, and widening of the ascending aorta in a significant number of patients. All girls and women with TS should have careful echocardiographic evaluation upon diagnosis to identify the one in three asymptomatic individuals with an abnormal valve requiring monitoring for aortic root dilatation and valvular dysfunction.
Comparison of alcoholic chlorhexidine and povidone–iodine cutaneous antiseptics for the prevention of central venous catheter-related infection: a cohort and quasi-experimental multicenter study
Authors: Justine Pages, Pascal Hazera, Bruno Mégarbane, Damien du Cheyron, Marie Thuong, Jean-Jacques Dutheil, Xavier Valette, François Fournel, Leonard A. Mermel, Jean-Paul Mira, Cédric Daubin, Jean-Jacques Parienti
Journal: Intensive Care Medicine (2016)
Post-transcriptional Gene Silencing Induced by Short Interfering RNAs in Cultured Transgenic Plant Cells
Authors: Wei Tang, Vanessa Samuels, Nicki Whitley, Nicole Bloom, Tinya DeLaGarza, Ronald J. Newton
Journal: Genomics Proteomics & Bioinformatics (2004)

Abstract Short interfering RNA (siRNA) is widely used for studying post-transcriptional gene silencing and holds great promise as a tool for both identifying function of novel genes and validating drug targets. Two siRNA fragments (siRNA-a and -b), which were designed against different specific areas of coding region of the same target green fluorescent protein (GFP) gene, were used to silence GFP expression in cultured gfp transgenic cells of rice (Oryza sativa L.; OS), cotton (Gossypium hirsutum L.; GH), Fraser fir [Abies fraseri (Pursh) Poir; AF], and Virginia pine (Pinus virginiana Mill.; PV). Differential gene silencing was observed in the bombarded transgenic cells between two siRNAs, and these results were consistent with the inactivation of GFP confirmed by laser scanning microscopy, Northern blot, and siRNA analysis in tested transgenic cell cultures. These data suggest that siRNA-mediated gene inactivation can be the siRNA specific in different plant species. These results indicate that siRNA is a highly specific tool for targeted gene knockdown and for establishing siRNA-mediated gene silencing, which could be a reliable approach for large-scale screening of gene function and drug target validation.
Sister Joseph's Nodule and Malignant Ascites in Multiple Myeloma
Authors: H Bank, S I Liberman
Journal: New England Journal of Medicine (1971)

This letter relates to the increased number of multiple fibroadenomas seen in women receiving hormonal contraceptives.  12 patients aged 17-30 years were found to have 2-4 nodules which increased rapidly in size while on oral contraceptives and prompted surgical intervention.
Effect of Severe Hypoalbuminemia on Myelosuppression and Other Toxicities of High Dose Melphalan and Autologous Stem Cell Transplantation in AL Amyloidosis Patients
Authors: Robert Meehan, David Seldin, John Mark Sloan, Karen Quillen, Dina Brauneis, Anthony C Shelton, Vaishali Sanchorawala
Journal: Blood (2014)
Physician advocacy deficit.
Authors: E P Schonfeld
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.9.1838 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8355054 Physician advocacy deficit. E P SchonfeldxE P SchonfeldSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.9.1838 PDF "Physician advocacy deficit.." Journal of Clinical Oncology, 11(9), pp. 1838–1839© 1993 by American Society of Clinical Oncology
Correlation Between Serum Ofatumumab Concentrations, Baseline Patient Characteristics and Clinical Outcomes in Patients with Fludarabine-Refractory Chronic Lymphocytic Leukemia (CLL) Treated with Single-Agent Ofatumumab.
Authors: Anders Österborg, Birgitte Biilmann Ronn, Roxanne C Jewell, Thomas J Kipps, Jiri Mayer, Stephan Stilgenbauer, Cathy D Williams, Andrzej Hellmann, Tadeusz Robak, Richard R Furman, Peter Hillmen, Marek Trneny, Martin JS Dyer, Swami Padmanabhan, Magdalena Piotrowska, Tomas Kozak, Geoffrey Chan, Michael Arning, Nedjad Losic, Randy Davis, Joris Wilms, Charlotte A Russell, William G Wierda
Journal: Blood (2009)
Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study
Authors: Tetsuro Araki, Rachel K. Putman, Hiroto Hatabu, Wei Gao, Josée Dupuis, Jeanne C. Latourelle, Mizuki Nishino, Oscar E. Zazueta, Sila Kurugol, James C. Ross, Raúl San José Estépar, David A. Schwartz, Ivan O. Rosas, George R. Washko, George T. O’Connor, Gary M. Hunninghake
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

The relationship between the development and/or progression of interstitial lung abnormalities (ILA) and clinical outcomes has not been previously investigated.To determine the risk factors for, and the clinical consequences of, having ILA progression in participants from the Framingham Heart Study.ILA were assessed in 1,867 participants who had serial chest computed tomography (CT) scans approximately 6 years apart. Mixed effect regression (and Cox) models were used to assess the association between ILA progression and pulmonary function decline (and mortality).During the follow-up period 660 (35%) participants did not have ILA on either CT scan, 37 (2%) had stable to improving ILA, and 118 (6%) had ILA with progression (the remaining participants without ILA were noted to be indeterminate on at least one CT scan). Increasing age and increasing copies of the MUC5B promoter polymorphism were associated with ILA progression. After adjustment for covariates, ILA progression was associated with a greater FVC decline when compared with participants without ILA (20 ml; SE, ±6 ml; P = 0.0005) and with those with ILA without progression (25 ml; SE, ±11 ml; P = 0.03). Over a median follow-up time of approximately 4 years, after adjustment, ILA progression was associated with an increase in the risk of death (hazard ratio, 3.9; 95% confidence interval, 1.3-10.9; P = 0.01) when compared with those without ILA.These findings demonstrate that ILA progression in the Framingham Heart Study is associated with an increased rate of pulmonary function decline and increased risk of death.
Case 38-1989
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Jerome P. Richie, John H. Eichhorn
Journal: New England Journal of Medicine (1989)

Presentation of CaseA 19-year-old man was admitted to the hospital because of fever, left upper abdominal pain, anemia, and weight loss.He was well until six weeks earlier, when left flank pain developed, with a sensation of chilliness; there was no antecedent trauma, and no urinary tract symptoms were recalled. A physician found that the patient was afebrile and noted the absence of flank tenderness. The weight was 66.8 kg. Urinalysis showed + + red cells and + white cells; a culture yielded less than 10,000 colonies per cubic millimeter of gram-positive microorganisms. Trimethoprim–sulfamethoxazole was prescribed, and the patient . . .
Career choices for the woman psychiatric resident
Authors: E P Benedek, E Poznanski
Journal: American Journal of Psychiatry (1980)

The transition from residency to the active practice of psychiatry is a difficult, complex, and relatively unexplored one for both men and women. Women who have faced this transition have only recently begun to share experiences, problems, fantasies, and special knowledge. The authors illustrate career choices for women that have aspects which are different from those male residents must consider and which create transitional problems. They suggest two possible strategies to those who supervise women professionals during this transition. The first is an active counseling program at the end of residency training, adequately staffed by professional men and women. The second strategy for a new psychiatrist would be to participate in a continuing women's group.
HG-110SINGLE-CELL TRANSCRIPTOME ANALYSIS IN PEDIATRIC HEMISPHERIC AND MIDLINE HIGH-GRADE GLIOMAS
Authors: Mariella G. Filbin, Itay Tirosh, Leah E. Escalante, Andrew S. Venteicher, Liliana Goumnerova, Kristine Pelton, Pratiti Bandopadhayay, Christopher Mount, Irene Slavc, Thomas Czech, Johannes Gojo, Cinzia Lavarino, Jaume Mora, Michelle Monje, Mark W. Kieran, Keith L. Ligon, Todd Golub, Aviv Regev, Mario L. Suva
Journal: Neuro-Oncology (2016)
Endoscopic resection of a duodenal web in an 11-month-old infant with multiple malformations
Authors: Cosimo Bleve, Lorenzo Costa, Valeria Bertoncello, Francesco Ferrara, Elisa Zolpi, Salvatore Chiarenza
Journal: Endoscopy (2015)

Duodenal atresia and duodenal stenosis are rare causes of intestinal obstruction in the newborn; the prevalence of intrinsic duodenal obstruction (atresia, web, or severe stenosis) is 1 in 6000 [1] [2]. The webs are thin, consisting of mucosa and submucosa and usually lacking a muscular layer. The clinical presentation of affected patients includes intermittent, recurrent bilious vomiting and upper abdominal distension [3] [4].
Clinical and functional differences between early-onset and late-onset adult asthma: a population-based Tasmanian Longitudinal Health Study
Authors: Daniel J Tan, E Haydn Walters, Jennifer L Perret, John A Burgess, David P Johns, Adrian J Lowe, Caroline J Lodge, Panteha Hayati Rezvan, Julie A Simpson, Stephen Morrison, Bruce R Thompson, Paul S Thomas, Iain Feather, Graham G Giles, John L Hopper, Michael J Abramson, Melanie C Matheson, Shyamali C Dharmage
Journal: Thorax (2016)

Differences between early-onset and late-onset adult asthma have not been comprehensively described using prospective data.To characterise the differences between early-onset and late-onset asthma in a longitudinal cohort study.The Tasmanian Longitudinal Health Study (TAHS) is a population-based cohort. Respiratory histories and spirometry were first performed in 1968 when participants were aged 7 (n=8583). The cohort was traced and resurveyed from 2002 to 2005 (n=5729 responses) and a sample, enriched for asthma and bronchitis participated in a clinical study when aged 44 (n=1389).Of the entire TAHS cohort, 7.7% (95% CI 6.6% to 9.0%) had early-onset and 7.8% (95% CI 6.4% to 9.4%) late-onset asthma. Atopy and family history were more common in early-onset asthma while female gender, current smoking and low socioeconomic status were more common in late-onset asthma. The impact on lung function of early-onset asthma was significantly greater than for late-onset asthma (mean difference prebronchodilator (BD) FEV1/FVC -2.8% predicted (-5.3 to -0.3); post-BD FEV1FVC -2.6% predicted (-5.0 to -0.1)). However, asthma severity and asthma score did not significantly differ between groups. An interaction between asthma and smoking was identified and found to be associated with greater fixed airflow obstruction in adults with late-onset asthma. This interaction was not evident in adults with early-onset disease.Early-onset and late-onset adult asthma are equally prevalent in the middle-aged population. Major phenotypic differences occur with asthma age-of-onset; while both share similar clinical manifestations, the impact on adult lung function of early-onset asthma is greater than for late-onset asthma.
High frequency of HLA-Bw16 in patients with anorexia nervosa
Authors: J Biederman, T M Rivinus, D B Herzog, J S Harmatz, K Shanley, E J Yunis
Journal: American Journal of Psychiatry (1984)

Anorectic patients (N = 37) had a higher frequency of HLA-Bw16 than normal controls, due to the higher frequency of HLA-Bw38. They also had a higher rate of A26-Bw38. HLA typing may lead to hypotheses about the biology of anorexia nervosa.
Imatinib mesylate in advanced chordoma: A multicenter phase II study
Authors: S. Stacchiotti, S. Ferrari, V. Ferraresi, G. Grignani, F. Crippa, A. Messina, C. Spreafico, E. Tamborini, A. Gronchi, P. G. Casali
Journal: Journal of Clinical Oncology (2007)

10003 Background: The antitumor activity of Imatinib in chordoma was preliminarily shown in a compassionate series of 18 pts. This prospective Phase II collaborative study was planned thereafter. Methods: From November 2004 to April 2006, 55 pts with progressing advanced chordoma were enrolled in this Phase II study. Cases were provided by 13 Italian centers and one Swiss. Imatinib was given at the planned dose of 800 mg/day (for a received dose intensity in excess of 600 mg/day), until evidence of progression. Mean age was 59 yrs, (range 24–86); PS 0–3 (=2 in 22%); site of origin was the sacrum in 60%, spine in 25%, skull base in 15%; the disease was metastatic in 43% and localized advanced in 57%. All tumors were positive for PDGFRB/PDGFB. Results: In 44 pts evaluable for antitumor response, 37 (84%) had stable disease as their best RECIST response, which was maintained for more than 6 months in 32, for a clinical benefit rate (CR+PR+SD=6mos) of 73%. In 7 of these SD pts (16%), a degree of objective tumor shrinkage was reported. Centralized radiological review is underway, focusing on non-dimensional, “tissue” response, and results thereof will be presented. In 39 pts who were symptomatic at baseline, subjective improvement of symptoms was claimed by 25 (64%). On ITT analysis, median PFS was 32 wks, with 38% of pts free from progression at one year, and 16% on treatment at 18 months. Most frequent drug-related adverse events were nausea (35%) and vomiting (30%), edema (30%), skin rash (28%), G1–3 anemia (24%), asthenia (17%), G1–3 leucopenia (13%). Conclusions: Preliminary evidence of Imatinib efficacy in chordoma was provided in a single-institution, compassionate setting, and is now confirmed by this multicenter Phase II study. On the basis of these data, an international effort on molecular-targeted therapy with Imatinib in advanced chordoma is warranted. No significant financial relationships to disclose.
Methods of Conditioning the Graft in Tumor Transplantation&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: T S HAUSCHKA
Journal: JNCI Journal of the National Cancer Institute (1953)

Methods of Conditioning the Graft in Tumor Transplantation, Get access Theodore S. Hauschka Theodore S. Hauschka Institute for Cancer Research and Lankenau Hospital Research Institute, Philadelphia, Pa. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 723–743, https://doi.org/10.1093/jnci/14.3.723 Published: 01 December 1953
Neuroendocrine dysfunction in schizophreniform disorder: correlation with six-month clinical outcome
Authors: S D Targum
Journal: American Journal of Psychiatry (1983)

The thyrotropin-releasing hormone (TRH) stimulation test and the dexamethasone suppression test (DST) were administered to 21 patients with schizophreniform disorder at the time of admission for acute illness: 9 showed dysregulation on one or the other test. Seventeen patients followed for 6 months were divided into two groups: those with persistent dysfunction and/or psychotic symptoms and those in full remission. Only 1 of 7 patients (14%) with persistent dysfunction in contrast to 7 of 10 patients (70%) in full remission revealed dysregulation on either test. Neuroendocrine challenges may be useful in the early assessment of first-break psychotic patients, and neuroendocrine dysregulation may be a predictor of episodic illness with a better prognosis.
Potentiation of antidepressant medications by phase advance of the sleep-wake cycle
Authors: D A Sack, J Nurnberger, N E Rosenthal, E Ashburn, T A Wehr
Journal: American Journal of Psychiatry (1985)

Four patients with major depression who were unresponsive to antidepressant medications rapidly improved and remained euthymic after an advance of the sleep-wake cycle. Phase advance of the sleep-wake cycle and antidepressant treatment may have complementary effects on the circadian system. The authors suggest that the combination may be useful in treating drug nonresponders and in hastening response to antidepressant drugs.
Choosing the Metal Biliary Stent Type for Palliation of Neoplastic Stenosis during Endoscopic Retrograde Cholangiopancreatography
Authors: S Mosca
Journal: Endoscopy (2003)

Biliary stenting is a well-established treatment for unresectable neoplastic biliary stenosis. Unfortunately, however, there is as yet no consensus regarding the choice of the appropriate stent type relative to the patient or the stenosis. Many types of plastic stent are available, and reports have compared these without establishing any significant differences. When the metal biliary stent first became available 10 years ago, it was enthusiastically welcomed. Some reports have described advantages in the durability of metal stents in comparison with plastic ones, but the principal indication for metal stents is still in patients who have an anticipated survival period of more than 3 - 6 months [1]. Although many types of metallic biliary stent are now available, it is not known which type is best able to improve cost-effectiveness and quality of life, since criteria for choosing stents are lacking. Only a few papers so far have reported experience with a single type of metal biliary stent, or have compared two types of metal biliary stent. The paper by Ahmad et al., published in a recent issue of Endoscopy, was therefore welcome, as it addressed a very important topic in the clinical practice of therapeutic endoscopy [2]. The paper reports experience with two types of metal biliary stent - the Ultraflex Diamond stent and the biliary Wallstent. The Ultraflex metal stent had a similar occlusion rate to the Wallstent, but the time to occlusion and the patency period were poorer than with the Wallstent and were quite similar to those of plastic stents. I read the paper with great interest and would like to make some comments on it.
Tracheo-esophageal fistula following spontaneous migration of a missed impacted denture
Authors: Deepak Gunjan, Surinder Rana, Rajesh Gupta, Deepak Bhasin
Journal: Endoscopy (2015)

A 50-year-old woman presented with dysphagia and cough that occurred while she drank liquids. She had been treated elsewhere with endoscopic bougie dilation for mechanical dysphagia 3 years earlier. Barium esophagography at that time showed narrowing of the upper thoracic esophagus with mucosal irregularity ([Fig. 1]). Endoscopy revealed luminal narrowing, but multiple endoscopic biopsies as well as computed tomography of the chest did not reveal any specific pathology. She remained asymptomatic for 3 years following the dilation procedure.
Why healthcare professionals should know a little about infographics
Authors: Hilary Scott, Samantha Fawkner, Chris Oliver, Andrew Murray
Journal: British Journal of Sports Medicine (2016)

Infographics is an abbreviated term for an information graphic. Information is presented in a logical manner, similar to storytelling, using data visualisations, text and pictures.1 Statistically, the most successful infographics, in terms of number of ‘shares’ on social media, contain an average of 396 words2 and a combination of data visualisations (bar graphs, line graphs and pie charts) and illustrations. Although 396 words may seem like an inadequate amount of text for researchers to convey their findings comprehensively, when considering this in the infographics context, the saying, ‘a picture tells a thousand words’, comes to mind. Three days after learning new information, we are likely to remember up to 6.5 times more through learning from an infographic than by reading text alone.1 Many industries, such as the business, food, …