tbuckley/cabot-search huggingface dataset:
2015 ACC/AHA/SCAI Focused Update on Primary Percutaneous Coronary Intervention for Patients With ST-Elevation Myocardial Infarction
Authors: Glenn N. Levine, Eric R. Bates, James C. Blankenship, Steven R. Bailey, John A. Bittl, Bojan Cercek, Charles E. Chambers, Stephen G. Ellis, Robert A. Guyton, Steven M. Hollenberg, Umesh N. Khot, Richard A. Lange, Laura Mauri, Roxana Mehran, Issam D. Moussa, Debabrata Mukherjee, Henry H. Ting, Patrick T. O’Gara, Frederick G. Kushner, Deborah D. Ascheim, Ralph G. Brindis, Donald E. Casey, Mina K. Chung, James A. de Lemos, Deborah B. Diercks, James C. Fang, Barry A. Franklin, Christopher B. Granger, Harlan M. Krumholz, Jane A. Linderbaum, David A. Morrow, L. Kristin Newby, Joseph P. Ornato, Narith Ou, Martha J. Radford, Jacqueline E. Tamis-Holland, Carl L. Tommaso, Cynthia M. Tracy, Y. Joseph Woo, David X. Zhao
Journal: Journal of the American College of Cardiology (2015)
Clinical patterns of metastatic spread from formalin-fixed, paraffin-embedded (FFPE) expression profiles: A case-control study of 1,357 breast cancer patients
Authors: K. Lawler, E. Papouli, A. Tutt, T. Ng, S. Pinder, P. Parker, L. Holmberg, C. Gillett, A. Grigoriadis, A. Purushotham
Journal: Annals of Oncology (2015)
Persistent Rash in a Patient Receiving Total Parenteral Nutrition
Authors: Stacey A. Maskarinec, Vance G. Fowler
Journal: JAMA (2016)

A 50-year old man receiving total parenteral nutrition presented with a desquamating rash on his face, scalp, inguinal region, and perineum as well as diffuse alopecia of the face, scalp, axillae, and groin. What would you do next?
Diagnostic Ultrasound Impulses Improve Microvascular Flow in Patients With STEMI Receiving Intravenous Microbubbles
Authors: Wilson Mathias, Jeane M. Tsutsui, Bruno G. Tavares, Feng Xie, Miguel O.D. Aguiar, Diego R. Garcia, Mucio T. Oliveira, Alexandre Soeiro, Jose C. Nicolau, Pedro A. Lemos, Carlos E. Rochitte, José A.F. Ramires, Roberto Kalil, Thomas R. Porter
Journal: Journal of the American College of Cardiology (2016)
Antiretroviral Drugs and the Risk of Myocardial Infarction
Authors: Robert Zangerle, Mario Sarcletti
Journal: New England Journal of Medicine (2007)

The editorialist replies: In my editorial, the reference to Dr. Chang’s letter was not intended to support the absence of long-term adverse renal 1. effects associated with zoledronic acid but, rather, to provide a context in which the long-term renal safety in the HORIZON study could be regarded as reassuring. As Dr. Chang points out, long-term adverse effects of zoledronic acid on renal function have been documented in a small number of patients and remain a potential concern.
Rounds
Authors: Paul Rousseau
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelet MAO in children with attention deficit disorder and hyperactivity: a pilot study
Authors: W O Shekim, L G Davis, D B Bylund, E Brunngraber, L Fikes, J Lanham
Journal: American Journal of Psychiatry (1982)

The authors examined platelet MAO activity in 8 hyperactive and 18 control children who were admitted to a clinical research center and placed on a low monoamine diet. After 5 days, their blood was analyzed; the hyperactive children were discharged on day 7, placed on d-amphetamine for 2 weeks, and readmitted for repeat blood analysis. The hyperactive children initially had significantly lower levels of platelet MAO than the controls. After the hyperactive children were treated with d-amphetamine for 2 weeks, their platelet MAO levels were comparable to those of the control children. The authors suggest an association between low platelet MAO activity and a behavioral state of overactivity, short attention span, and impulsivity.
EPID-15FAMILIAL PREDISPOSITION TO HIGH GRADE ASTROCYTOMA
Authors: Kevin Graf, Ramiro Mancilla, Edana Stroberg, Samantha Dayawansa, Jason Huang, Ekokobe Fonkem
Journal: Neuro-Oncology (2015)

INTRODUCTION and BACKGROUND: Glioblastoma Multiforme (GBM) accounts for 17% of all brain cancers, making up approximately 65% of all astrocytomas. While genetic constitution of this tumor has been researched extensively, the possibility of a predisposition due to familial inheritance has not been investigated to a remarkable extent. METHODS: Here, we describe a case series of a local family consisting of three individuals, father at age 38 years, and two biological children ages 6 and 20 years diagnosed with glioblastoma. The father and 6 year old daughter are deceased and the son is still undergoing treatment. Next gen sequencing was performed on their brain tissues. CONCLUSION: This case series illustrates that glioblastoma might have a familial predisposition as potential risk factor. This case series opens the door for further investigation of genetics as a potential risk factor for high grade glioma.
Postcoupling, Noncoupling, and Fluorescence Techniques for the Demonstration of Alkaline Phosphatase
Authors: M. S. Burstone
Journal: JNCI Journal of the National Cancer Institute (1960)

The development and use of new post-coupling, noncoupling, and fluorescence techniques for the demonstration of alkaline phosphatase are described. The techniques utilize new substrates, derivatives of hydroxynaphthoic acid, and complex amines. Three of the most useful substrates are 5,6,7,8-β-tetralol carboxylic acid-β-naphthylamide phosphate (I), 2-hydroxy-3-naphthoic acid-2-aminoanthraquinonylamide phosphate (II), and 2-hydroxy-3-naphthoic acid-aminoazobenzanilide phosphate (III). The techniques, which are designed primarily for use with paraffin-embedded tissues, give sharp localizations. These compare with the best results obtained by the simultaneous-coupling technique. In the case of one substrate, an anthraquinone derivative (II), postfixed frozen sections give useful results. The naphthol released from substrate I is a fluorochrome and is the basis of a new avenue of approach in enzyme histochemistry, namely, the visualization of enzyme activity by fluorescence. This and another substrate also liberate naphthols, which are visible under optical magnification without postcoupling. This application is referred to as a noncoupling procedure. For most purposes, a postcoupling procedure utilizing substrates II or III is recommended. The incubating solutions are stable, and subsequent postcoupling may be accomplished with a large variety of diazonium salts. These techniques also lend themselves to the demonstration of hydrolytic enzymes other than alkaline phosphatase.
Abstract P4-09-04: Robust 7-gene signature for recurrence prognosis of breast cancer validated in formalin-fixed paraffin-embedded samples
Authors: RJ Chacolla, VM Trevino, SP Scott, EA Guzman, S Cardona
Journal: Cancer Research (2016)

Abstract BACKGROUND: Breast cancer (BC) is a heterogeneous disease with diverse biological-molecular characteristics and clinical behaviors. Traditionally, prediction of recurrence in patients recently diagnosed is a big challenge for oncologists. In the last decade, advances in gene expression profiling technologies have improved the genetic knowledge of breast cancer by reporting several prognostic gene-signatures. However, there is still a need for covering the molecular heterogeneity of this cancer. Integration of public microarray data could be used to identify better and robust predictive gene-signatures. The aim of this study was to investigate prognostic genes that might function as biomarkers to differentiate among all heterogeneous BC patients, into those with high, medium or low recurrence risk. METHODS: We collected nine public datasets, 1574 BC patients with median follow-up time of 10 years. The data were split into train-test, 50% each. Train was subject to univariate and multivariate analysis to generate a signature, which was validated in the test data. Seven genes were identified with high accuracy for recurrence prediction. This signature was validated in 40 formalin-fixed paraffin-embedded (FFPE) Mexican BC tissues with clinical follow up of 3 to 13 years by quantitative RT-PCR assays. RESULTS: We identified a 7-gene signature which showed an accuracy prediction measured by concordance index of 65.62% and Log-rank test p-value: 1 x 10-15. The validation of the gene-signature level expression in 40 FFPE samples in Kaplan Meier analysis showed prediction significance by concordance index of 65.25% and Log-Rank p-value: 0.0005. CONCLUSIONS: This 7-gene signature may provide a powerful tool to guide the adequate treatment protocols in early-diagnosed breast cancer patients. Citation Format: Chacolla RJ, Trevino VM, Scott SP, Guzman EA, Cardona S. Robust 7-gene signature for recurrence prognosis of breast cancer validated in formalin-fixed paraffin-embedded samples. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-09-04.
Government is starting to recognise pressures on general practice, GPs told
Authors: Anne Gulland
Journal: BMJ (2016)

NHS England’s plans to transform general practice were not the “final word” in rescuing the profession, Chaand Nagpaul, chair of the BMA’s general practice committee has said.

In a speech to the annual conference of local medical committees, Nagpaul said that the General Practice Forward View ,1 which promised a £2.4bn (€3bn; $3.5bn) cash injection into general practice by 2020-21, represented a “symbolic change in language, headlining pressures in general practice and the need for support and investment.” However, it was not the “final word in rescuing general practice.”

Nagpaul’s speech painted a picture of general practice in crisis, with GPs …
Medicaid Coverage and Access to Care for American Indians and Alaska Natives Under the Affordable Care Act
Authors: Samantha Artiga, Barbara Lyons
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
<sup>11</sup>C-Methionine-PET in Multiple Myeloma: Correlation with Clinical Parameters and Bone Marrow Involvement
Authors: Constantin Lapa, Stefan Knop, Martin Schreder, Martina Rudelius, Markus Knott, Gerhard Jörg, Samuel Samnick, Ken Herrmann, Andreas K. Buck, Hermann Einsele, Katharina Lückerath
Journal: Theranostics (2015)

Multiple myeloma (MM) remains an essentially incurable hematologic malignancy originating from clonal plasma cells. This study evaluated the usefulness of the radiotracers (11)C-methionine (MET) and (18)F-2`-deoxy-2`-fluorodeoxyglucose (FDG) for staging and re-staging in MM. 43 patients with MM underwent both MET- and FDG-PET/CT for staging or re-staging within 3±2 days. Scans were compared on a patient and on a lesion basis. Tracer uptake was correlated with the degree of bone marrow (BM) involvement and standard clinical parameters of disease activity. Additionally, BM samples were stained for L-type amino acid transporter 1 (LAT1) expression in 15 patients. MET-PET detected focal lesions (FL) in 39/43 subjects (90.7%), whereas 10 patients were missed in FDG-PET/CT (detection rate, 33/43; 76.7%; p<0.05). MET depicted more FL in 28/43 patients (65.1%; p<0.001), whereas in the remainder (34.9%, n=15) both tracers yielded comparable results. LAT1 was highly expressed on the cell surface of myeloma cells. Both FDG and MET uptake correlated significantly with biopsy-proven BM involvement (p<0.001), with MET demonstrating a stronger correlation (SUVmean, r=0.9 vs r=0.6; SUVmax, r=0.88 vs r=0.58). Abnormal beta-2-microglobulin and free light chain levels correlated with the presence of focal intramedullary lesions detected in MET- or FDG-PET/CT (MET, p=0.006 and p=0.01, respectively; FDG, p=0.02 and p=0.01). MET appears to be superior to FDG for staging and re-staging of both intra- and extramedullary MM lesions. Tracer uptake correlates with BM involvement, β2m and FLC levels and appears to be a more accurate marker of tumor burden and disease activity.
Loss of the mismatched human leukocyte antigen haplotype in two acute myelogenous leukemia relapses after haploidentical bone marrow transplantation with post-transplantation cyclophosphamide
Authors: S R McCurdy, B S Iglehart, D A Batista, C D Gocke, Y Ning, H A Knaus, A M Jackson, M S Leffell, L Luznik, I Gojo
Journal: Leukemia (2016)
Transcultural investigation of recent symptomatology of schizophrenia in China
Authors: Y F Hsia, N Tsai
Journal: American Journal of Psychiatry (1981)

During the past 15 years a number of new symptoms, rarely seen in the past, have been observed with increasing frequency among Chinese schizophrenic patients. The authors identify the following symptoms: discordant (dissociative) syndrome, denial of lineage, delusion of leadership lineage, delusion of being married, child-bearing delusion, delusion of being despised, delusion of imminent catastrophe, delusion of influence, inferential delusion, delusion of being experimented on, delusion of conducting an experiment, delusion of being cultivated by superiors, delusion of being tested, delusion of being examined, delusion of impending arrest, delusion of being slandered, mirror symptom, and syndrome of changing dialects.
Familial Lupus Erythematosus
Authors: W. N. Beaucher, R. H. Garman, J. J. Condemi
Journal: New England Journal of Medicine (1977)

Familial systemic lupus erythematosus offers a unique opportunity to evaluate the role of genetic immunologic and viral factors in its patho-genesis. In the 25 years since the report of the disease in twins,1 there have been approximately 50 families in which multiple members have been found to have systemic lupus erythematosus.2 3 4 5 6 In addition to an increased familial occurrence of various autoimmune diseases, antinuclear antibody and numerous serologic abnormalities have been found in family members.4 Spontaneous systemic lupus erythematosus has also been described in dogs, and can include facial rash, polyarthritis, nephritis, autoimmune hemolytic anemia, L.E.-cell phenomenon and antibody to nucleic . . .
Rosuvastatin Lowers Circulating Tissue Factor Antigen-Bearing Microparticles In Metastatic Breast Cancer: A Phase II, Multi-Dose, Randomized Trial (MicroSTAT Trial)
Authors: Jeffrey I. Zwicker, Erica L. Mayer, Federico Campigotto, Julia Geddings, Herold Christina, Sheryl Bowley, Gerburg Wulf, Gary Horowitz, Donna S. Neuberg, Nigel Mackman, Bruce Furie
Journal: Blood (2013)
Metastatic spinal cord compression: diagnosis and management
Authors: Rasha Al-Qurainy, Emily Collis
Journal: BMJ (2016)

#### What you need to know

Between five and 10 in every 200 patients with terminal cancer will have metastatic spinal cord compression (MSCC) within their last two years of life. It is an oncological emergency.1 2 MSCC is caused by compression of the dural sac and its contents (spinal cord or cauda equina) by an extradural or intradural mass,3 and it leads to irreversible neurological damage such as paraplegia or tetraplegia depending on the level of the lesion. Extradural masses are the more common, and their causes and presentation are the focus of this review.

Haematogenous spread with bony metastasis to the vertebral spine causes collapse and compression, accounting for over 85% of MSCC.4 5 However, local tumour extension into the spinal cord and deposition of tumour cells directly within the spinal cord from a distant tumour are two other recognised mechanisms.6 7

Early diagnosis and treatment are essential to prevent permanent neurological damage, so early recognition by non-specialists coupled with rapid referral pathways and treatment are required.

#### Sources and selection criteria

We carried out a search through Medline of articles published in English up to February 2016 using the terms “malignant spinal cord compression” and “metastatic spinal cord compression” and through the National Cancer Institute and Cochrane Library using the term “spinal cord compression.” We also searched the UK NICE (National Institute for Health and Care Excellence) Library for published guidance and the National Collaborating Centre for Cancer …
THE BACTERIOLOGIC DIAGNOSIS OF DIPHTHERIA.
Authors: S Petroussenko
Journal: JAMA (1904)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AP-2gamma as a novel biomarker of endocrine resistance: Results from the TransCONFIRM study
Authors: L. Malorni, C. Biagioni, C. Guarducci, M. Bonechi, G. Capaccioli, R. Jeselsohn, W.T. Barry, N. Laing, A. Di Leo, I. Migliaccio
Journal: Annals of Oncology (2015)
Exposure of human CD34+ cells to human immunodeficiency virus type 1 does not influence their expansion and proliferation of hematopoietic progenitors in vitro
Authors: S Kaushal, VF La Russa, S Gartner, S Kessler, S Perfetto, Z Yu, DW Ritchey, J Xu, P Perera, J Kim, T Reid, DL Mayers, D St. Louis, JD Mosca
Journal: Blood (1996)
Brain stem death and organ donation.
Authors: C Davies
Journal: BMJ (1989)

Our understanding of the concept and definition of death has changed over time. The British contribution to the body of knowledge on the diagnosis of brain steam death was the publication by the medical royal colleges (1976) of diagnostic criteria. Most literature and research which explores the knowledge and attitudes of nurses towards the concept of brain stem death is from the USA. Several issues which arise from the literature are discussed in relation to organ donation. Further UK-based research is required.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1972)

COMMITTEE ON MATERNAL WELFAREFatal Perineal SepsisThe unremarkable prenatal course of a 23-year-old gravida 1 ended at 42 weeks with spontaneous rupture of the membranes and delivery within 10 hours by outlet forceps under spinal anesthesia. The 2950-g infant and the third stage of labor were normal. A median episiotomy extended through the sphincter and and for a short distance in the left vaginal wall, but repair was easily accomplished. Mother and baby were discharged on the fourth post-partum day apparently in good condition.Severe abdominal pain and fever on the 5th day prompted readmission at midnight with a . . .
Abstract 39: Association of single nucleotide polymorphisms (SNPs) in STS and SULT2B1 and response to androgen deprivation therapy (ADT) in men with advanced hormone sensitive prostate cancer (aHSPC)
Authors: Neeraj Agarwal, Tyler Buckley, James Farnham, Shiven B. Patel, Archana Agarwal, Srinivas Tantravahi, Craig Teerlink, Frederick S. Albright, Robert A. Stephenson, Anitha Alex, Lisa Cannon-Albright
Journal: Clinical Cancer Research (2016)

Abstract Background: Germline variations in genes involved in androgen biosynthesis and metabolic pathways may predict time to response to androgen deprivation therapy (ADT) in aHSPC, serve as prognostic and predictive biomarkers, and guide towards more individualized upfront therapy. Methods: 795 single nucleotide polymorphisms (SNPs) from the Illumina OmniExpress genotyping platform within the boundaries of 60 genes reported to be involved in the androgen metabolic pathway were investigated for association with time to onset of castration resistance prostate cancer (CRPC) in 118 Caucasian men with aHSPC, i.e. those progressing after definitive treatment, undergoing treatment with ADT. Cox proportional hazard analysis was employed using Gleason score as a covariate and assessing each SNP under an additive genetic model in which the number of minor alleles contributes increasing risk (or protection). Results: Three SNPs in STS (steroid sulfatase gene), and three SNPs in SULT2B1 (sulfotransferase 2B1 gene) were significantly associated with time to CRPC on ADT while controlling for Gleason Score (p &amp;lt; .005). Conclusions: SNPs in STS and SULT2B1 significantly associated with time to CRPC on ADT in aHSPC, and may serve as predictive markers to ADT in this setting. Data are being validated in a larger cohort. Citation Format: Neeraj Agarwal, Tyler Buckley, James Farnham, Shiven B. Patel, Archana Agarwal, Srinivas Tantravahi, Craig Teerlink, Frederick S. Albright, Robert A. Stephenson, Anitha Alex, Lisa Cannon-Albright. Association of single nucleotide polymorphisms (SNPs) in STS and SULT2B1 and response to androgen deprivation therapy (ADT) in men with advanced hormone sensitive prostate cancer (aHSPC). [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr 39.