tbuckley/cabot-search huggingface dataset:
AB1132 Development of Quality Criteria for the Assessment of Care in Rheumatoid Arthritis
Authors: J.L. Andreu, M.A. Martín-Martínez, H. Corominas, J.J. Pérez-Venegas, J.A. Román-Ivorra, F. Sánchez-Alonso, M. Alperi, R. Blanco, R. Caliz, E. Chamizo, G. Graña, B. Hernández-Cruz, C. Marras, J.M. Martín-Santos, R. Mazzucchelli, J. Medina, A. Naranjo, A. Ortiz, R. Rosellό, G. Sánchez-Nievas, R. Sanmartí, P. Vela
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Treat to Target strategy (T2T) for RA includes an early diagnosis and start of Disease Modifying Antirheumatic Drugs (DMARDs) targeted to achieve remission (or low inflammatory activity) defined by composite measures, and periodic adjustment of treatment in order to reach pre-defined goals. <h3>Objectives</h3> The aim of our work was to develop a tool to evaluate the quality of care in patients with RA according to the T2T strategy. <h3>Methods</h3> Firstly, the scientific committee of the project proposed a series of quality criteria about different aspects of RA managing, like time to diagnosis and to starting the first DMARD, establishment of therapeutic targets, therapy intensification according to a pre-defined target, optimal use of methotrexate, evaluation of comorbidities and the use of safety measures before biological therapy. In a second phase, this set of criteria was submitted for evaluation by a group of 20 experts who, in two Delphi rounds, scored the relevance of the criteria and the feasibility of being obtained by retrospective evaluation of clinical records. Those criteria with a median score ≥7.5 in the Delphi rounds, both for relevance and feasibility, an IQ range ≤2.5, and a degree of agreement (score ≥8) ≥80%, were selected. <h3>Results</h3> Initially, 37 quality criteria were proposed. They were submitted to a first Delphi round. Twelve of them needed a second round, since they did not reach consensus initially. After the analysis of the second round, a consensus was reached for 31 criteria. Some of these criteria were: a period &lt;2 weeks between the first visit to the rheumatologist and the RA diagnosis; a period &lt;2 weeks from the first consultation to the beginning of the first DMARD; to consider criteria of poor prognosis to decide the therapy; advice of quitting smoking and reaching ideal body weight; evaluation of disease activity by indexes like the 28 joints-Disease Activity Score (DAS28) or Simple Disease Activity Index (SDAI); clinical evaluations every 4 weeks until reaching the target; therapeutic intensification according to a pre-defined target; ordering chest X-ray and tuberculosis tests before starting biological therapy; recording cardiovascular risk factors; advice about vaccination for flu and pneumococcus; or taking into account comorbidities in the decision of therapy. <h3>Conclusions</h3> We have developed a set of criteria for the assessment of quality in the clinical management of RA, according to the T2T strategy. <h3>Disclosure of Interest</h3> None declared
Boy Drinking
Authors: Janet M. Torpy
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0857 Standardized Optimization of Analgesics in Patients with Knee Osteoarthritis and Severe Pain – a Feasibility Study
Authors: J.A.C. van Tunen, M. van der Leeden, W. Bos, J. Cheung, M. van der Esch, M. Gerritsen, W.F. Peter, L.D. Roorda, G.J. Tijhuis, R. Voorneman, J. Dekker, W.F. Lems
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Prescription of analgesics is complex in patients with knee OA and severe pain. We developed a protocol for the standardized prescription of analgesics based on the World Health Organization analgesic ladder (1) and the Beating osteoARTritis (BART) strategy for stepped care in hip and knee OA (2). <h3>Objectives</h3> The aim of this study was to evaluate the feasibility and outcome of the analgesic protocol. <h3>Methods</h3> Forty-nine patients with knee OA and severe knee pain (NRS≥7; range 0-10) were included. Analgesics were prescribed following an incremental protocol (Figure 1) for a period of six weeks. Pain intensity was evaluated every two weeks. When there was insufficient pain reduction (NRS-pain&gt;5), a consultation at the rheumatologist was planned to offer an analgesic of the next step. Analgesics of the next step were added to analgesics of the previous step(s). Analgesic use was recorded. Knee pain (NRS-pain) and activity limitations (WOMAC-PF) were measured. Data were collected at baseline and after six weeks. Subsequently, patients started with exercise therapy. <h3>Results</h3> At baseline 84% of the patients used analgesics. Of all patients, 77% used acetaminophen, 36% used NSAIDs and 16% used weak opioids. At baseline, analgesics were used irregularly and at an suboptimal dose. Analgesic use after six weeks is described in Figure 1. The maximal daily dosage was used in 93% of the patients that used acetaminophen, in 66% of the patients that used NSAIDs, and in 44% of the patients that used weak opioids. Combinations of analgesics were common. No serious adverse events occurred. In 39% of the patients NRS-pain was ≤5 after six weeks. Despite NRS-pain&gt;5, a further step in the analgesic protocol was not accepted by the patient (n=14) or not prescribed by the rheumatologist (n=13), the latter mostly due to contra-indications or side effects. Statistically significant and clinically relevant mean improvements from baseline were 19% (p&lt;0.001) for pain and 12% (p=0.002) for activity limitations after six weeks. <h3>Conclusions</h3> After six weeks, patients used analgesics regularly and often at a preferential dose. Prescription of analgesics following an incremental protocol reduces pain and activity limitations in patients with knee OA and severe pain. <h3>References</h3> World Health Organization. Cancer pain relief: with a guide to opioid availability. Available at: http://whqlibdoc.who.int/publications/9241544821.pdf (accessed 14 January 2014). Smink AJ, et al. Clin Rheumatol 2011;30:1623-9. <h3>Disclosure of Interest</h3> None declared
Liver-Glucuronidase Activity of Inbred Mouse Strains&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Andrew G. Morrow, Ezra M. Greenspan, Dorothy M. Carroll
Journal: JNCI Journal of the National Cancer Institute (1949)

Liver-Glucuronidase Activity of Inbred Mouse Strains Get access Andrew G. Morrow, Andrew G. Morrow Search for other works by this author on: Oxford Academic PubMed Google Scholar Ezra M. Greenspan, Ezra M. Greenspan Search for other works by this author on: Oxford Academic PubMed Google Scholar Dorothy M. Carroll Dorothy M. Carroll Clinical Research Unit, National Cancer Institute, U. S. Marine Hospital, and Department of Preventive Medicine, The Johns Hopkins University School of Medicine, Baltimore, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 657–661, https://doi.org/10.1093/jnci/10.3.657 Published: 01 December 1949 Article history Received: 23 August 1949 Published: 01 December 1949
What gets passed in “Chunk-and-Pass” processing? A predictive processing solution to the Now-or-Never bottleneck
Authors: Sam Wilkinson
Journal: Behavioral and Brain Sciences (2016)

Abstract I agree with the existence, and importance, of the “Now-or-Never” bottleneck. However, there is a far simpler and more parsimonious solution to it. This solution is predictive processing, and the failure to view the solution that this provides fundamentally boils down to viewing prediction as one aspect of cognition, rather than as its central principle.
SAT0343 How Much Does Fatigue Contribute to the Physician and Patient Global Estimates in Different Rheumatic Diseases? Analysis from Routine Care on a Multidimensional Health Assessment Questionnaire (MDHAQ)
Authors: I. Castrejon, E. Nikiphorou, R. Jain, A. Huang, J.A. Block, T. Pincus
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Fatigue is an important problem for many patients with rheumatic diseases. Fatigue has been associated with disease severity, psychological distress, and a poorer quality of life in rheumatoid arthritis (RA) [1]. Although an important symptom for patients, it is controversial how much fatigue may contribute to the level of disease activity. <h3>Objectives</h3> To evaluate possible associations between fatigue and global estimates of disease activity according to the patient and the physician in patients with different rheumatic diseases. <h3>Methods</h3> All patients seen in one academic clinical setting complete a multidimensional health assessment questionnaire (MDHAQ) in 5-10 minutes in the waiting area, prior to seeing the rheumatologist in the infrastructure of usual care. The two-page MDHAQ includes physical function (FN) in 10 activities of daily living, three 0-10 visual analog scale (VAS) for pain (PN), patient global estimate (PATGL), and fatigue (FT), and demographic data. PATGL and physician global estimate (DOCGL) were used to define four disease activity categories at the following predefined levels: &lt;1 for “inactive disease”, 1-3 for “low”, 3-6 for “moderate”, and &gt;6 for “high”. Median values for fatigue and interquartile range (IQR) were compared in 4 categories according to 4 diagnoses: rheumatoid arthritis (RA), osteoarthritis (OA), systemic lupus erythematosus (SLE), and fibromyalgia (FM). <h3>Results</h3> Analyses included 612 consecutive patients, 173 with RA, 199 with OA, 146 with SLE and 94 with FM. Median fatigue score was significantly higher in FM (7, IQR=5-8) p&lt;0.001, but similar in RA (4, IQR=1-7), OA (5, IQR=2-7.5), and SLE (5, IQR=1.5-7.5). Fatigue scores were significantly higher according to disease activity categories in RA, OA and SLE patients, as reported by the patients and by the DOCGL, suggesting associations with diseases that are characterized by structural involvement of the musculoskeletal system (Table). In contrast, this pattern was not observed in patients with FM. <h3>Conclusions</h3> Fatigue scores are associated with severity of disease activity in structural conditions such as RA, OA, and SLE, but do not appear to be similarly associated in myofascial pain syndromes. This is evident both from the physician9s and from the patient9s perspective. Fatigue is a relevant and important symptom, which can be collected in the infrastructure of routine care as a quantitative VAS on an MDHAQ in patients with all rheumatic diagnoses. <h3>References</h3> Nikolaus S, Bode C, Taal E, et al. Fatigue and factors related to fatigue in rheumatoid arthritis: a systematic review. Arthritis Care Res (Hoboken) 2013; 65:1128-46 <h3>Disclosure of Interest</h3> None declared
Cortisol, growth hormone, free fatty acids, and experimentally evoked affective arousal
Authors: W A Brown, G Heninger
Journal: American Journal of Psychiatry (1975)

Eight male volunteers who viewed selected control, suspense, and erotic films experienced significant changes in affect that were limited to fatigue, anxiety, and sexual arousal, respectively. All subjects showed free fatty acid elevations with the suspense and erotic films and those subjects with the most anxiety and sexual arousal showed cortisol elevation with the suspense and erotic films, respectively. Growth hormone elevations occurred independently of cortisol elevations and were not clearly related to film or affect. Thus, activation of the pituitary-adrenocortical and sympathetic nervous systems appears to occur not in relation to a specific dysphoric state but rather with nonspecific affective arousal.
Cord
Authors: Jennifer A Markowitz
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lactate sensitivity and cardiac cholinergic function in panic disorder
Authors: V K Yeragani, K Srinivasan, R Balon, C Ramesh, R Berchou
Journal: American Journal of Psychiatry (1994)

Using spectral analysis of the continuous time series signal before and during lactate and placebo infusions, the authors studied heart rate variability in six patients with panic disorder and nine normal comparison subjects. The decrease in high-frequency (0.20-0.50 Hz) power and the increase in sympathovagal ratios (mid-frequency [0.07-0.15 Hz] to high-frequency powers) after the administration of intravenous sodium lactate were significantly greater in the patients than in the normal subjects after correction of the values for the amount of lactate infused. This result suggests an exaggerated cardiac vagal withdrawal in patients with panic disorder during lactate infusions.
Influence of polyphenol-mediated peroxide generation on redox-markers in the colon cell line HT-29
Authors: Christine Janzowski, Phillip Bellion, Matthias Baum, Gerhard Eisenbrand
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

5461 

There is considerable interest in beneficial health effects of diets containing fruits, vegetables, and beverages e.g. apples and apple juices. Proposed benefits of these foods on prevention of cancer have in part been attributed to phenolic constituents, which display a spectrum of bioactive effects, including antioxidant activity. However, polyphenols / flavonoids can also exert prooxidative effects, which in vitro depend on assay conditions and structure of the compounds. In this study, polyphenol-mediated hydrogen peroxide (H2O2) formation was determined by ferrous oxidation - xylenol orange (FOX1)-assay after incubation in Dulbecco’s Modified Eagle Medium (DMEM) with / without human colon carcinoma HT-29 cells. Additionally, effects of extracellular peroxide on the cellular markers total glutathione (GSH) - and peroxide induced ROS-level (photometric GSH- and dichlorofluorescein-assay) were studied by incubating with / without addition of catalase (± KAT).    Significant time- and concentration dependent H2O2 formation was observed at polyphenol concentrations >10µM in DMEM (without cells) in the following order: caffeic acid > chlorogenic acid > quercetin > rutin > phloridzin = phloretin. Additionally, polyphenolic apple juice extracts were found to generate H2O2, relying on the concentration of the constituent chlorogenic acid. In DMEM / Nutrient Mix F12 (1:1), another commonly used cell culture medium, no polyphenol-mediated H2O2 was detectable under these conditions. Addition of KAT to DMEM resulted in depletion of H2O2 down to the level of solvent control. In the presence of HT-29 cells (- KAT), extracellular H2O2 concentration was similarly decreased; this effect might be ascribed to cellular uptake or antioxidant defense. Significant and concentration dependent induction of GSH level was found already at 10µM quercetin (- KAT), and not until 30µM quercetin (+ KAT). With caffeic acid, no such effect on GSH elevation was observed. This suggests a compound specific induction of GSH synthesis, mediated at least in part by extracellular H2O2. At variance to GSH, the cellular ROS-level was not modulated by addition of KAT during incubation with quercetin or caffeic acid.    Taken together, the results substantiate earlier findings on generation of hydrogen peroxide in cell culture medium at incubation with apple phenolics. Extracellular catalase as well as cellular defense processes scavenge H2O2. Phenolic structure, incubation time and type of medium govern hydrogen peroxide generation. H2O2 in the medium, however, has no influence on cellular ROS-level, obviously due to efficient antioxidant defense. In contrast, GSH level is raised by H2O2, presumably by inducing glutathione synthesis.    Support: Federal Ministry of Education and Research (grant no. 01EA0501).
FRI0395 Anti -N-Methyl-D-Aspartate Receptor Antibody is Associated with Fibromyalgia in Patients with Systemic Lupus Erythematosus
Authors: D.-J. Park, J.-W. Lee, K.-E. Lee, S.-S. Lee
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> The high concordance of systemic lupus erythematosus (SLE) with fibromyalgia (FM) suggests common underlying mechanisms related to pain and distress in both patient groups. This study was aimed to evaluate roles of NMDAR antibodies in development of FM in SLE patients <h3>Methods</h3> Sera from 104 SLE patients, 112 FM patients, and 110 healthy controls were analyzed to detect titers of antibodies to N-terminus of 2B subunit of NMDAR (GluN2B). Clinical, laboratory data and concomitant diseases were found by reviewing the patient charts. We underwent clinical examination and neuropsychiatric evaluation, and interviewed SLE patients using a structured questionnaire that included FM and neuropsychiatric symptoms. <h3>Results</h3> 18 patients (17.3%) of total 104 SLE patients were revealed having FM. The titer of anti-GluN2B antibodies was significantly higher in SLE patients than FM patients and healthy controls (<i>P</i> &lt;0.001). In SLE patients, patients with concomitant FM showed higher titers of anti-GluN2B antibodies (<i>P</i> &lt;0.05). The titers of anti-GluN2B antibodies were correlated with tender point count (Spearman9s rho =0.238, <i>P</i>=0.016) and widespread pain index (Spearman9s rho =0.276, <i>P</i>=0.005), but not with other symptom scales. Anti-GluN2B antibody-positive SLE patients were more likely to have NPSLE and concomitant FM (P&lt;0.05). In multivariate analysis, Anti-GluN2B antibody was independent predictor of concomitant FM and NPSLE. <h3>Conclusions</h3> This is the first study to present that antibodies to NMDAR may be associated with pathogenesis of FM in SLE patients. <h3>Disclosure of Interest</h3> None declared
Historical Y. pestis Genomes Reveal the European Black Death as the Source of Ancient and Modern Plague Pandemics
Authors: Maria A. Spyrou, Rezeda I. Tukhbatova, Michal Feldman, Joanna Drath, Sacha Kacki, Julia Beltrán de Heredia, Susanne Arnold, Airat G. Sitdikov, Dominique Castex, Joachim Wahl, Ilgizar R. Gazimzyanov, Danis K. Nurgaliev, Alexander Herbig, Kirsten I. Bos, Johannes Krause
Journal: Cell Host & Microbe (2016)
Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity
Authors: Xia Li, Qian Zhang, Yuanyuan Ding, Yiqi Liu, Dezhi Zhao, Kai Zhao, Qicong Shen, Xingguang Liu, Xuhui Zhu, Nan Li, Zhongyi Cheng, Guoping Fan, Qingqing Wang, Xuetao Cao
Journal: Nature Immunology (2016)
CDC Grand Rounds: Understanding the Causes of Major Birth Defects — Steps to Prevention
Authors: Regina M. Simeone, Marcia L. Feldkamp, Jennita Reefhuis, Allen A. Mitchell, Suzanne M. Gilboa, Margaret A. Honein, John Iskander
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Major birth defects (birth defects) are defined as structural abnormalities, present at birth, with surgical, medical, or cosmetic importance. Each year in the United States, 3% of live births (approximately 120,000 infants) have an identifiable structural birth defect. Examples of birth defects include neural tube defects, such as spina bifida; orofacial clefts; abdominal wall defects, such as gastroschisis; and congenital heart defects, such as hypoplastic left heart syndrome. Collectively, congenital heart defects are the most common birth defects (27%), followed by musculoskeletal defects (18%), genitourinary defects (15%), orofacial defects (5%), and neural tube defects (2%).
AB0985 The Influence of Etanercept on Inflammation Markers and Lipid Profile in Patients with Juvenile Idiopathic Arthritis
Authors: J. Basic, J. Vojinovic, G. Susic, D. Pavlovic, T. Jevtovic-Stoimenov, V. Djordjevic, V. Milosevic
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Chronic inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus had been proven to have a higher risk of atherosclerosis and premature coronary artery disease. On the other hand, the role of inflammation on dyslipidemia in patients with juvenile idiopathic arthritis (JIA), is not yet well established. <h3>Objectives</h3> We have investigated whether etanercept (tumor necrosis factor-α receptor blocking agent) has the influence on inflammation markers and lipid profile in patients with JIA, after 1 year of treatment. <h3>Methods</h3> A total of 50 patients with active polyarticular JIA and 31 healthy children were enrolled in the study. JIA patients donated paired blood samples prior to and 12 months after etanercept therapy. Inflammation markers (erythrocite sedimentation rate (ESR), white blood cells count (WBC) and C-reactive protein (CRP) level), as well as serum cholesterol, triacylglycerol, LDL-C and HDL-C levels were determined using standard biochemical analysis. <h3>Results</h3> ESR, WBC count and CRP levels were significanly higher in JIA patients before treatment in comparison to control (p=0.001, p=0.048, p&lt;0.001, respectively). Etanercept treatment significantly decreased ESR, WBC count and CRP levels in JIA patients in comparison to the values from before (p=0.011, p=0.039, p=0.016). Serum levels of cholesterol, triacylglycerol and LDL-C in JIA patients before treatment showed increase compared to control values (p=0.013, p=0.001, p=0.044). On the other hand HDL-C levels were lower in JIA patients in comparison to control (p&lt;0.001). Etanercept treatment significantly decreased triacylglycerol levels and increased HDL-C levels in JIA patients compared to baseline values (p=0.020, p=0.007). There is a negative correlation between ESR and HDL-C levels either before or after etanercept treatment (p=0.001, p=0.041). <h3>Conclusions</h3> Patients with JIA showed disturbances in serum lipid profile. Etanercept treatment in JIA patients increased the levels of HDL-C and lowered triacylglycerol levels in comparison to baseline values. <h3>References</h3> Kuo-Wei Yeh et al. PLoS One 2014;9(3):1-7. Breda L et al. Clin Res Cardiol 2013;102:63–71. <h3>Disclosure of Interest</h3> None declared