tbuckley/cabot-search huggingface dataset:
The difference of long-term hair recovery among chemotherapeutic regimens in breast cancer patients.
Authors: Hiroshi Yagata, Takanori Watanabe, Hiroko Okada, Mitsue Saito, Tomoko Takayama, Hirohisa Imai, Yuko Yoshida, Nao Tamai, Keiko Nozawa, Tamiko Yajima, Takafumi Sangai, Akiyo Yoshimura, Yoshie Hasegawa, Takako Doi, Yasuo Ohashi, Kojiro Shimozuma
Journal: Journal of Clinical Oncology (2015)

e17673 Background: Hair loss is a distressing side effect of chemotherapy. We conducted a national survey to evaluate the effects of chemotherapy on change in appearance and the status of support for breast cancer patients. Here, we analyzed the long-term rate of hair recovery after chemotherapeutic regimens. Methods: Questionnaires were sent to domestic hospitals, distributed to patients by doctors in their outpatient clinics, and then mailed directly to the data center. The content included changes in their appearance (hair, eyebrows, eyelashes, nail, and skin) and the status of their support. Inclusion criteria were breast cancer patients without signs of recurrence who had received pre- or post-operative chemotherapy within 5 years, and were limited to the combination of following chemotherapeutic regimens: anthracycline + cyclophosphamide +/- 5-FU (AC), weekly paclitaxel (P), or docetaxel (D) every 3 weeks. The rate of hair recovery by the regimens was analyzed according to the duration after chemotherapy in a cross-sectional manner, adjusting for age ( < 50/ ≥ 50) and endocrine therapy (aromatase inhibitor (AI)/except for AI/no use). Results: Of the questionnaires collected from 1511 patients from 47 hospitals (82%), 1448 were analyzed (excluding > 5 years after chemotherapy, or regimens of only P, P+D, or AC+P+D). Time after chemotherapy was < 1 year, 1–3 years, and 3–5 years in 28%, 43%, and 28% of patients, respectively. Excluding no response, a ≥ 80% hair recovery occurred in < 1 year, 1–3 years, and 3–5 years in 52.7%, 63.5%, and 61.5% of the population, respectively. Moreover, rates of ≥ 80% hair recovery in 3–5 years were 88.9%, 64.1%, 63.5%, and 43.4% for AC, AC+P, D, and AC+D, respectively, and there were significant differences among the regimens after adjusting for age and endocrine therapy (AC vs. AC+P/AC+D, D/AC+P vs. AC-D; P < 0.001, AC vs. D; P = 0.004, AC+P vs. D; ns). Conclusions: A significant number of breast cancer patients are yet to completely recover from hair loss, years after chemotherapy. The rate of hair recovery tends to be lower with taxanes, especially in regimens containing docetaxel. Therefore, medical staff should consider hair loss support in the long term for breast cancer patients.
A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail
Authors: Debra A Goff, Ravina Kullar, Ellie J C Goldstein, Mark Gilchrist, Dilip Nathwani, Allen C Cheng, Kelly A Cairns, Kevin Escandón-Vargas, Maria Virginia Villegas, Adrian Brink, Dena van den Bergh, Marc Mendelson
Journal: The Lancet Infectious Diseases (2016)
THU0401 Severe Bone Marrow Edema on Sacroiliac Joint MRI Increases The Risk of Low BMD in Patients with Axial Spondyloarthritis
Authors: K.Y. Kang, Y.S. Hong
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Patients with axSpA have an increased risk of low bone mass. AS patients have a high prevalence of osteoporosis, which is observed in both early and advanced cases. A recent study showed that nr-axSpA patients show significantly greater bone loss than patients with mechanical back pain. <h3>Objectives</h3> To determine the association between inflammatory and structural lesions on sacroiliac joint (SIJ) MRI and BMD and to identify risk factors for low BMD in patients with axial spondyloarthritis (axSpA). <h3>Methods</h3> Seventy-six patients who fulfilled the ASAS axSpA criteria were enrolled. All underwent SIJ MRI and BMD measurement at the lumbar spine, femoral neck, and total hip. Inflammatory and structural lesions on SIJ MRI were scored. Laboratory tests and assessment of radiographic and disease activity were performed at the time of MRI. The association between SIJ MRI findings and BMD was evaluated. <h3>Results</h3> Among the 76 patients, 14 (18%) had low BMD. Patients with low BMD showed significantly higher bone marrow edema (BME) and deep BME scores on MRI than those with normal BMD (p&lt;0.047 and 0.007, respectively). Inflammatory lesions on SIJ MRI correlated with BMD at the femoral neck and total hip. Multivariate analysis identified the presence of deep BME on SIJ MRI, increased CRP, and sacroiliitis on X-ray as risk factors for low BMD (OR: 5.6, 14.6, and 2.5, respectively). <h3>Conclusions</h3> The presence of deep BME on SIJ MRI, increased CRP levels, and severity of sacroiliitis on X-ray were independent risk factors for low BMD. <h3>Disclosure of Interest</h3> None declared
FRI0341 Do Patients with SLE at Onset Differ from Mimickers? A Comparison of Clinical and Serological Manifestations in A Multicenter Cohort To Inform The Development of New Classification Criteria for SLE: Table 1
Authors: Z. Touma, K.H. Costenbader, S. Johnson, M. Mosca, B.F. Hoyer, S. Navara, E. Bonfa, R. Ramsey-Goldman, J. Medina-Rosas, C. Tani, A. Fine, S. Tedeschi, V. Lorenzoni, G.D. Sebastiani, T. Dorner, M. Aringer
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Current SLE classification criteria may not classify patients with early SLE well. SLE mimickers can have an initial presentation similar to SLE and need to be distinguished from early SLE patients by classification criteria. <h3>Objectives</h3> To describe the clinical and serological presenting manifestations of SLE at disease onset and those of SLE mimickers. <h3>Methods</h3> We collected clinical and laboratory data on patients newly presenting with potential SLE (symptoms &lt;12 months) within the past 3 years at centers in Europe (2), North America (3), South America (1) and Asia (1). Patients were diagnosed as SLE or mimicking conditions by clinical experts. We compared the presenting manifestations in SLE vs. mimickers. We examined combinations of autoantibodies, clinical and laboratory manifestations for their association with SLE vs. SLE mimickers in multivariable analyses. <h3>Results</h3> Of 616 patients, 389 were diagnosed with SLE (89% female) and 227 were given other diagnoses (97% female). A smaller proportion of SLE patients than patients with mimicking conditions were White (55% vs. 90%). Mimickers included UCTD, Sjögren9s syndrome, rheumatoid arthritis, scleroderma, and fibromyalgia. Clinical and autoantibodes presenting manifestations in new onset SLE and mimickers are represented in table 1. In univariable analyses, the following autoantibodies profiles were associated with SLE vs. mimickers: Profile 1 (ANA, anti-Sm, anti-Ro and anti-RNP; OR 3.49, 95% confidence interval [CI] 2.29–5.31) and Profile 2 (ANA, anti-cardiolipin IgG/IgM, Beta2 and lupus anticoagulant; OR 2.82, 95% CI 1.75–4.55). In multivariable analyses, the following autoantibodies profiles were associated with SLE vs. mimickers: Profile 1 (OR 3.02, 95% CI 1.90–4.80) and Profile 2 (OR 3.11, 95% CI 1.80–5.36). Adding hypocomplementemia to Profile 1 and 2 showed a high association with SLE [OR 3.40, 95%CI 2.21–5.22 and OR 2.41, 95%CI 1.53–3.80] respectively. <h3>Conclusions</h3> We identified clinical manifestations and autoantibodies more commonly associated with SLE than with mimickers at initial presentation. Autoantibody profiles particularly including ANA and especially in the presence of hypocomplementemia, showed associations with SLE. <h3>Acknowledgement</h3> New SLE classification criteria for clinical research are being developed, sponsored by EULAR and ACR. <h3>Disclosure of Interest</h3> None declared
Impact of Transporter Genes Polymorphisms in Standard Induction of Acute Myeloid Leukemia
Authors: Juan Eduardo Megías, Pau Montesinos, María José Herrero, Federico Moscardó, Virginia Bosó, David Martínez-Cuadrón, Luis Rojas, Rebeca Rodríguez-Veiga, Blanca Boluda, Jesús Martínez, Jaime Sanz, Francisca López, Isabel Cano, Aima Lancharro, Jose Cervera, David Hervás, José Luis Poveda, Salvador F Aliño, Miguel Ángel Sanz
Journal: Blood (2015)
Profound Length Heteroplasmic Alterations in Mitochondrial DNA Control Region From Primary AML Cells: Implication of Impaired Mitochondrial Replication and Demonstration of ‘vicious cycle’ Hypothesis.
Authors: Myung-Geun Shin, Hye Ran Kim, Hyeoung-Joon Kim, Hoon Kook, Tai Ju Hwang, Jong-Hee Shin, Soon-Pal Suh, Dong-Wook Ryang
Journal: Blood (2009)
Modified Thalidomide, Cyclophosphamide and Dexamethasone (TCD) to Patients with Multiple Myeloma as Primary Therapy Prior to Peripheral Blood Stem Cell Collection.
Authors: Deok-Hwan Yang, Je-Jung Lee, Yeo-Kyeoung Kim, Jin-Ho Baek, Sang-Kyun Sohn, Choi-Young Jin, Ho-Jin Shin, Hyeoung Joon Kim
Journal: Blood (2005)
Influence of the FCGR3A-158 V/F and FCGR2A-131 H/R Polymorphism on the Response to Rituximab Therapy in Immune Thrombocytopenic Purpura and Autoimmune Hemolytic Anemia.
Authors: F. Javier Peñalver, Carlos Vilches, Alberto Albarez-Larran, Isidro Jarque, M.J. Rodriguez, Laura Gallur, Dolores Caballero, Javier Castaño, M.J. Fernandez, J. Rafael Cabrera
Journal: Blood (2007)
PTU-029 Nice Classification for Optical Diagnosis of Colonic Lesions is Equally Applicable When Using Blue Laser Imaging
Authors: R Rameshshanker, A Wilson, S Thomas-Gibson, N Suzuki, P Tekkis, BP Saunders
Journal: Gut (2016)

<h3>Introduction</h3> Optical diagnosis of colonic polyps offers the potential for significant improvements in colonoscopy efficiency and cost saving. BLI is a new, push button, image enhancement endoscopy technology using two laser light sources to accentuate mucosal surface and vascular pattern of polyps. It’s visual appearance is similar to NBI. This study assessed whether the validated NICE classification system for colonic polyps (NBI) was applicable for BLI images of polyps. <h3>Objectives</h3> To assess whether NICE classification could be used to interpret BLI images To assess the diagnostic performance of BLI imaging modalities in characterising colonic polyps <h3>Methods</h3> High quality still images of 25 polyps were retrieved from an endoscopy image database. For each polyp we examined 4 different images: BLI, BLI with magnification (BLI MAG), BLI bright (BLI BR) and BLI BR with magnification (BLI BR MAG) (total of 100 images). Four experienced endoscopists were asked to make an optical diagnosis based on NICE (NBI International Colo rectal Endoscopic classification) for each BLI modality images. <h3>Results</h3> A total of 100 polyp images were reviewed. Reviewers were able to identify a minimum of one NICE feature in all cases (100%) and all three NICE features (colour, vessel and surface pattern) in 90% of the images. There was no significant difference in the accuracy of predicting polyp histology between BLI BR and BLI BR MAG (89.6% vs 92%, p = 0.47) or BLI and BLI MAG (90.5% vs 92%, p = 0.8). However, the confidence levels were significantly increased when presented with magnified images (BLI BR vs BLI BR MAG, 55.4% vs 91.3%, p &lt; 0.0001 and BLI vs BLI MAG 55.3% vs 91.3%). <h3>Conclusion</h3> Our preliminary data highlights that the NICE classification could be used efficiently to interpret BLI images. The confidence levels in making an optical diagnosis were significantly increased with BLI magnification. Further studies are needed to validate these observations. <h3>Disclosure of Interest</h3> None Declared
Prolonged Clinical and Molecular Remissions Following High-Dose Therapy/Autologous Stem Cell Transplantation (HDT/ASCT) and Rituximab and Interferon-alpha Maintenance for Relapsed High-Risk Follicular Lymphoma.
Authors: Matthew C. Cheung, Neil L. Berinstein, Nancy Pennell, Lisa K. Hicks, Kevin R. Imrie, Eugenia Piliotis, Violet Milliken, Marciano Reis, Rena Buckstein
Journal: Blood (2007)
Metabolism-Induced Reactive Oxygen Species and Hif1α-Mediated Gene Regulation Control the Timing and Magnitude of Hematopoietic Stem Cell Induction
Authors: James M Harris, Lauren J. Harris, Andrew G Cox, Maija K Garnaas, Gregory M Frechette, Mauricio Cortes, Claire C Cutting, Michael C Dovey, Barry H. Paw, Matthew Vander Heiden, Wolfram Goessling, Trista E. North
Journal: Blood (2011)
Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow
Authors: Jean-Pierre Levesque, Valerie Barbier, Bianca Nowlan, Domenica McCarhty, Ingrid G Winkler
Journal: Blood (2011)
Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Authors: Zachary Steinhart, Zvezdan Pavlovic, Megha Chandrashekhar, Traver Hart, Xiaowei Wang, Xiaoyu Zhang, Mélanie Robitaille, Kevin R Brown, Sridevi Jaksani, René Overmeer, Sylvia F Boj, Jarrett Adams, James Pan, Hans Clevers, Sachdev Sidhu, Jason Moffat, Stéphane Angers
Journal: Nature Medicine (2016)
GSK-3β Negatively Regulates Megakaryocyte and Platelet Production in an In Vitro Human Bone Marrow Mononuclear Cell-Derived Differentiation System.
Authors: Yumiko Matsubara, Mitsuru Murata, Hidenori Suzuki, Kenji Yokoyama, Hiroaki Ishihara, Yoshiyuki Morishima, Toshiro Shibano, Yasuo Ikeda
Journal: Blood (2007)
Depression following Acute Coronary Syndrome: Time-Specific Interactions between Stressful Life Events, Social Support Deficits, and 5-HTTLPR
Authors: Jae-Min Kim, Robert Stewart, Hee-Ju Kang, Kyung-Yeol Bae, Sung-Wan Kim, Il-Seon Shin, Young Joon Hong, Youngkeun Ahn, Myung Ho Jeong, Hyuno Kang, Jin-Sang Yoon
Journal: Psychotherapy and Psychosomatics (2016)
Brazilian health authorities on alert after rise in deaths from chikungunya
Authors: Claudia Collucci
Journal: BMJ (2016)

At least 156 people are confirmed to have died from chikungunya virus in Brazil so far this year compared with six people in 2015, an increase of 2500%, according to data from the Ministry of Health. Another 432 deaths are suspected to be connected with arboviruses, such as dengue, zika, or chikungunya.

“Chikungunya is the most dangerous of the arboviruses, and is causing the highest mortality rate,” said Carlos Brito, a general practitioner, and professor at the Federal University of Pernambuco, in Recife, Brazil. He added that …
Adherence to a healthy lifestyle and the risk of type 2 diabetes in Chinese adults: a prospective, longitudinal cohort study
Authors: Jun Lv, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Junshi Chen, Zhengming Chen, Lu Qi, Liming Li
Journal: The Lancet Diabetes & Endocrinology (2016)
Glutathione S-Transferase T1 Mismatch and Presence of Anti-GSTT1 Antibodies In Hepatic Gvhd
Authors: María José Martínez-Bravo, Inmaculada Tallón, Ildefonso Espigado, Alvaro Urbano-Ispizua, Antonio Núñez-Roldán, Isabel Aguilera
Journal: Blood (2010)
Allogeneic Hematopoietic Stem Cell Transplantation From HBsAg-Positive Donors Into HBsAg-Negative Recipients: A Safety and Practicable Regimen Under Active Prophylactic Anti-HBV Therapy
Authors: Yongxian Hu, Yi Luo, Yamin Tan, Xiaoyu Lai, Jimin Shi, Jingsong He, Gaofeng Zheng, Weiyan Zheng, Wanzhuo Xie, Zhen Cai, He Huang
Journal: Blood (2011)
The Effect of G-CSF Mobilization on the Expression of Immunoregulatory-Associated Molecules and G-CSFR Gene in the Peripheral Blood γδ+ T Cells
Authors: Li Xuan, Xiuli Wu, Min Dai, Zhenyi Jin, Xinyu Wang, Sijian Yu, Yan Xu, Hui Liu, Zhiping Fan, Yangqiu Li, Qifa Liu
Journal: Blood (2014)
Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage
Authors: Ana C. Queirós, Renée Beekman, Roser Vilarrasa-Blasi, Martí Duran-Ferrer, Guillem Clot, Angelika Merkel, Emanuele Raineri, Nuria Russiñol, Giancarlo Castellano, Sílvia Beà, Alba Navarro, Marta Kulis, Núria Verdaguer-Dot, Pedro Jares, Anna Enjuanes, María José Calasanz, Anke Bergmann, Inga Vater, Itziar Salaverría, Harmen J.G. van de Werken, Wyndham H. Wilson, Avik Datta, Paul Flicek, Romina Royo, Joost Martens, Eva Giné, Armando Lopez-Guillermo, Hendrik G. Stunnenberg, Wolfram Klapper, Christiane Pott, Simon Heath, Ivo G. Gut, Reiner Siebert, Elías Campo, José I. Martín-Subero
Journal: Cancer Cell (2016)

We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We identified two MCL subgroups, respectively carrying epigenetic imprints of germinal-center-inexperienced and germinal-center-experienced B cells, and we found that DNA methylation profiles during lymphomagenesis are largely influenced by the methylation dynamics in normal B cells. An integrative epigenomic approach revealed 10,504 differentially methylated regions in regulatory elements marked by H3K27ac in MCL primary cases, including a distant enhancer showing de novo looping to the MCL oncogene SOX11. Finally, we observed that the magnitude of DNA methylation changes per case is highly variable and serves as an independent prognostic factor for MCL outcome.
Mechanism of Blood Coagulation by Non-Thermal Atmospheric Pressure Dielectric Barrier Discharge Plasma.
Authors: Gayathri Nagaraj, Manjula Balasubramanian, Sameer Kalghatgi, Andrew S. Wu, Ari D. Brooks, Gregory Fridman, Moogega Cooper, Victor N. Vasilets, Alexander Gutsol, Alexander Fridman, Gary Friedman
Journal: Blood (2007)
BMET-23ANG1005, A NOVEL BRAIN-PENETRANT PEPTIDE-TAXANE CONJUGATE, FOR THE TREATMENT OF CNS METASTASES FROM BREAST CANCER
Authors: Priya Kumthekar, Susan Bates, Santosh Kesari, Andrew Brenner, Carey Anders, Agustin Garcia, Nuhad Ibrahim, Katherine Tkaczuk, Shou-Ching Tang
Journal: Neuro-Oncology (2015)
BCR-ABL Positive Chronic Myeloid Leukaemia (CML) with Del 11q22 and JAK 2 V617F Positive Chronic Myelomonocytic Leukaemia (CMML) in One Patient – a Rare Coincidence
Authors: Sonja Burgstaller, Gerald Webersinke, Beate Mayrbaeurl, Thomas Kuhr, Josef Thaler
Journal: Blood (2011)
SAT0321 Prevalence and Mortality from Infections in Systemic Lupus Erythematosus Patients in A Tertiary Level Hospital
Authors: O. Vera Lastra, C. Camacho Guerra, M.A. Saavedra, M.D.P. Cruz Dominguez, G. Medina
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease characterized by clinically heterogeneous manifestations. Infections can be the initial trigger to the development of autoimmunity. Initial presentation of SLE can mimic infections, and in turn infections can mimic disease flares in established SLE. Infections are an important cause of morbidity and mortality in SLE. Bacterial infections are most frequent, followed by viral and fungal infections. The impaired cellular and humoral immune functions seen in patients with SLE are predisposing conditions. Disease activity and high doses of methylprednisolone or cyclophosphamide are well-recognized risk factors for infection. <h3>Objectives</h3> To determine the prevalence and mortality from infection in SLE patients as well as to identify etiology, associated factors to severity and site of infection. <h3>Methods</h3> We performed a retrospective study from 2010 to 2014 in a referral hospital. We analyzed risk factors (RF) on admission, involved organ, infectious type and etiology. Statistical analysis: We did descriptive statistical, Chi<sup>2,</sup> multivariate analysis. <h3>Results</h3> There were 328 patients, 87% women and 13% men, mean age 32.4±9.9 years. Infections as cause of hospitalizations were 42.2%, prevalence of infections was 49%, and mortality from severe infections was 45%. The RF for severe infections were: renal involvement Odds Ratio (OR) 3.057, P&lt;0.019; hematologic OR 1.9, p&lt;0.001; increased dsAnti-DNA RM 5.1 p&lt;0001, hypocomplementaemia: OR 2.673, P&lt;0.02, leukolymphopenia OR 2.5, p&lt;0001. Type of infecctions: bacterial 87%, viral: 3.4%, fungal: 8%, mycobacterial: 1.5%. Site of infection: lower respiratory tract 38%, urinary tract: 49% soft tissues: 6.1%, central nervous system: 1.2%, Others: 4.2%. Most frequent etiology agent were: bacterial: <i>S. aureus, E. coli, A. baumanii, E. faecalis. Virales: H. zoster, mycotic: candida albicans and M. tuberculosis.</i> <h3>Conclusions</h3> Infections are an important cause of morbidity, mortality and hospitalization in SLE patients. The lower respiratory tract infections of bacterial origen were most frequent. The renal and hematological involvement, increased dsAnti-DNA, hypocomplementaemia, and leukolymphopenia were the most important factors for severe infections. Infections in active SLE patients constitute a true challenge for the clinician <h3>References</h3> Lee YH, Choi SJ, Ji JD, Song GG. Overall and cause-specific mortality in systemic lupus erythematosus: an updated meta-analysis. Lupus. 2016 Jan 24. Tektonidou MG, Wang Z, Dasgupta A, Ward MM. Burden of Serious Infections in Adults With Systemic Lupus Erythematosus: A National Population-Based Study, 1996–2011. Arthritis Care Res (Hoboken). 2015;67:1078–85. <h3>Disclosure of Interest</h3> None declared
OC-085 Lower Gastrointestinal Polypectomy Competencies in the UK: Retrospective Analysis: Abstract OC-085 Table 1
Authors: A Rajendran, S Thomas-Gibson, R Rameshshanker, P Dunckley, N Sevdalis, A Haycock
Journal: Gut (2016)

<h3>Introduction</h3> The Directly Observed Polypectomy Skills (DOPyS) is a validated tool used to assess polypectomy skills in the UK.<sup>1</sup> The overall competency for polypectomy is graded on a scale of 1 to 4 and is used to certify trainees for level 1 polypectomy (size &lt; 1 cm) and level 2 polypectomy (size 0–2 cm). Trainees are certified as competent if they achieve grades 3 or 4 for more than 90% in their last 4 consecutive DOPyS and a caecal intubation rate (CIR) &gt;90% over last 3 months. The aim of the study was to investigate the progress of competency in polypectomy for endoscopy <h3>Methods</h3> Retrospective data from the e-portfolio from Jan 2009 to Sept 2015 was extracted using pre-determined criteria. 749 DOPyS data from 61 trainees was analysed. 42 trainees had achieved provisional (level 1 polypectomy) certification and 19 trainees in the same cohort subsequently achieved full (level 2 polypectomy) certification. Data collected included time (in days) &amp; number of lower GI procedures to the start of first recorded polypectomy assessment (1 st DOPyS), time in days needed to achieve level 1 &amp; level 2 competency from 1st DOPyS &amp; from the first recorded lower GI procedure, caecal intubation rate (CIR) at time of 1st DOPyS &amp; at last recorded DOPyS before certification. <h3>Results</h3> <h3>Conclusion</h3> Trainees in the UK start formative assessment for polypectomy after &gt; 130 lower GI procedures &amp; CIR of &gt;70% Median time for trainees to achieve level 1 &amp; level 2 competencies from 1st DOPyS is &lt; 2 years Median time for trainees to achieve level 1 competency from first recorded lower GI procedure is &gt; 3 years Time to progress to level 2 competency from level 1 competency is &gt; 200 days &amp; may correspond to the rarity of polyps &gt; 1cm in training cases Polypectomy competency in this cohort of UK trainees is achieved after reaching an overall CIR &gt;85% Further studies are needed to analyse the learning curve of polypectomy &amp; to implement changes to improve efficiency of training <h3>Reference</h3> 1 Gupta S, Bassett P, Man R, Suzuki N, Vance ME, Thomas-Gibson S. Validation of anovel method for assessing competency in polypectomy. <i>Gastrointest Endosc</i> 2012;<b>75</b>(3):568–575.e1. <h3>Disclosure of Interest</h3> None Declared