tbuckley/cabot-search huggingface dataset:
Study of anxiety and depression in cervical cancer survivors
Authors: S. Kim, J. Nam, S. Park, D. Bae, C. Park, C. Cho, J. Lee, Y. Yun
Journal: Journal of Clinical Oncology (2009)

e20644 Background: Cervical cancer is the second leading cause of cancer related deaths among women in Korea. However, few studies have been conducted to elucidate the psychological distress of this population. This study aimed to examine the prevalence of anxiety and depression among cervical cancer survivors, and to identify factors associated with such caseness. Methods: A total of 832 cervical cancer survivors recruited from six large hospitals in Korea completed a mailed survey, which included the Hospital Anxiety and Depression Scale (HADS), European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, and QLQ-CX24. Anxiety and depression were defined by a score of ≥ 8 on the HADS subscales. With a framework that included socio-demographic, clinical, and symptom characteristics, multivariate logistic regression models were used to identify factors associated with anxiety and depression. Results: Among cervical cancer survivors, 34.3% reported HADS-defined anxiety and 39.7% reported HADS-defined depression. Anxiety was associated with having a lower income (OR=1.95, p=.021), smoking (OR=2.42, p=.002), poor body image (OR=3.26, p&lt;.001), peripheral neuropathy (OR=2.21, p=.002), menopausal symptoms (OR=2.02, p=.004), and sexual inactivity (OR=2.35, p=.001). Depression was associated with younger age (OR=1.75, p=.006), having a lower income (OR=2.14 p&lt;.001), drinking (OR=1.56, p=.050), poor body image (OR=4.59, p&lt;.001), peripheral neuropathy (OR=2.34, p&lt;.001), and sexual inactivity (OR=2.68, p=.002). Both anxiety and depression were influenced by socio-demographic factors, health behaviors, and cervical cancer-specific symptom characteristics rather than cancer- or treatment-related factors. Conclusions: Anxiety and depression were highly prevalent among cervical cancer survivors in Korea. This examination of risk factors for anxiety and depression will be helpful for the development of clinical management strategies in cervical cancer survivors. No significant financial relationships to disclose.
Abnormal immune response to brain tissue antigen in the syndrome of autism
Authors: A Weizman, R Weizman, G A Szekely, H Wijsenbeek, E Livni
Journal: American Journal of Psychiatry (1982)

Cell-mediated immune response to human myelin basic protein was studied by the macrophage migration inhibition factor test in 17 autistic patients and a control group of 11 patients suffering from other mental diseases included in the differential diagnosis of the syndrome of autism. Of the 17 autistic patients, 13 demonstrated inhibition of macrophage migration, whereas none of the nonautistic patients showed such a response. The results indicate the existence of a cell-mediated immune response to brain tissue in the syndrome of autism.
Children in Australia's immigration centres
Authors: Ryan Essex
Journal: The Lancet (2016)

A Lancet Editorial (Feb 13, p 620)1 highlights the ongoing and widespread abuse in Australia's offshore immigration detention centres, in light of the recent High Court decision that ruled offshore detention of asylum seekers to be legal. While these issues are alarming on their own, they have come at a time when the government has taken steps to silence dissent and promote secrecy in Australia's detention process. One of the more publicised aspects of this government intervention was the introduction of the Border Force Act.
Higher weekend death rate is flawed, study finds
Authors: Jacqui Wise
Journal: BMJ (2016)

Fewer patients in England die after being admitted to hospital at the weekend than during the week, a large analysis has found, contradicting claims made by the health secretary, Jeremy Hunt, to justify imposing new contracts on junior doctors.1

The authors of the research, published in the Journal of Health Services Research and Policy , said their research showed that the so called “weekend effect” is a statistical artefact and that extending services will not reduce the number of deaths. They said that the death rate after a hospital admission at the weekend is higher only because the number of patients admitted at the weekend is lower and they tend to be sicker than those admitted during the week.

Previous studies comparing mortality risk have considered only those patients who were admitted to hospital. The new study instead looked at all patients attending emergency departments including those not admitted, …
The quest for autoreactive antibodies in nasal polyps
Authors: Els De Schryver, Lien Calus, Henryk Bonte, De Ruyck Natalie, Hannah Gould, Erin Donovan, Dirk Elewaut, Rudolf Valenta, Irene Mittermann, Jan Gutermuth, Tanja Seher, Robert P. Schleimer, Bruce K. Tan, Lara Derycke, Thibaut Van Zele, Claus Bachert, Philippe Gevaert
Journal: Journal of Allergy and Clinical Immunology (2016)
Left Atrial Appendage Closure in Patients With Contraindications to Oral Anticoagulation
Authors: Dinesh Sharma, Vivek Y. Reddy, Marcus Sandri, Philipp Schulz, Nicolas Majunke, Pavel Hala, Jens Wiebe, Tomas Mraz, Marc A. Miller, Petr Neuzil, Sven Möbius-Winkler, Horst Sievert, Peter Sick
Journal: Journal of the American College of Cardiology (2016)
Delayed Hematopoietic Recovery After Autologous Stem Cell Transplantation In Patients Receiving Arsenic Trioxide-Based Therapy For Acute Promyelocytic Leukemia
Authors: Gabriel N. Mannis, Lloyd E Damon, Weiyun Z. Ai, Charalambos Andreadis, Karin ML Gaensler, Neel K. Gupta, Lawrence D. Kaplan, Andrew D. Leavitt, Aaron C. Logan, Rebecca L. Olin, Peter H. Sayre, Catherine C Smith, Jeffrey M Venstrom, Thomas G Martin
Journal: Blood (2013)
Observational Study Alternating R-CHOP21 and R-Cytarabine (3+3 Cycles) for Patients with Newly Diagnosed Mantle Cell Lymphoma Not Eligible for High-Dose Therapy: A Czech Lymphoma Study Group Trial Preliminary Results
Authors: Pavel Klener, Eva Fronkova, Robert Pytlik, Marketa Kalinova, Kristina Forsterova, David Belada, Martin Simkovic, David Salek, Heidi Mocikova, Vit Prochazka, Vit Campr, Radek Jaksa, Jozef Kubinyi, Jiri Dolezal, Jan Trka, Marek Trneny
Journal: Blood (2014)
Replicating C-Type Virus in Phytohemagglutinin-Treated Buffy-Coat Cultures of Bovine Origin&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Neale D. Stock, Jorge F. Ferrer
Journal: JNCI Journal of the National Cancer Institute (1972)

Confirming previous work from other laboratories, numerous C-type, virus-like particles were observed in phytohemagglutinin (PHA)-treated, short-term cultures of buffy-coat (BC) cells from cows with lymphosarcoma or persistent lymphocytosis. In a detailed electron microscopic study of BC cultures from a cow with persistent lymphocytosis from a high-incidence lymphosarcoma family (BF-044), we conclusively demonstrated the occurrence of budding processes and thus the viral nature of the C-type particles. Addition of PHA to the cultures usually increased viral replication. However, virus was also consistently in control (non-PHA-treated) cultures and, in two experiments, in numbers at least equal to those in the PHA-treated cultures. This, together with the conspicuous absence of the virus in the BC cells before cultivation, indicated that the in vitro maintenance of these cells, and not PHA, is mainly responsible for the expression and/or replication of the virus. Our finding of virus in cultures grown without serum ruled out introduction of the virus via the fetal calf serum used to supplement the culture medium. Limited epidemiologic data emphasized the association of this virus with the occurrence of lymphosarcoma and/or lymphocytosis in the cattle population.
Breath analysis as a method for breast cancer early detection
Authors: C. W. Bayer, S. G. Gabram, R. J. Hendry, N. Sellers, M. B. Lund, W. Thompson, B. Vidakovic, B. Mizaikoff
Journal: Journal of Clinical Oncology (2008)

1522 Background: Breath markers from exhaled breath specimens have recently been utilized to detect lung cancer. Phillips et al has applied this technology to breast cancer (BC), identifying methylated-alkane patterns to predict the presence or absence of BC in 3 groups of women: those with and without BC on breast biopsy and age-matched healthy controls. The purpose of our study was to build on this work by collecting breath samples with a simple portable device, unique from prior work, to determine whether BC patients have breath volatile organic compound (VOC) patterns distinct from those in healthy volunteers. Methods: A prospective IRB-approved pilot study enrolled 19 healthy volunteers >40 years of age, BC-free within 5 years and a negative mammogram within one year of breath collection and 8 newly diagnosed stage II-IV BC patients. After fasting for 2 hours, the study subjects deeply exhaled into a Markes Bio VOC Breath Sampler 5 times at 5-minute intervals trapping alveolar breath VOCs. Potential interferents were identified through a subject questionnaire completed during the breath collection session. The exhaled breath samples were analyzed by thermal desorption/gas chromatography/mass spectrometry. Results: In conformance with other researchers, our results indicate that individual compound identification is not appropriate for determining the presence or absence of disease, but aggregate low-dimensional summaries and compound quantities result in specific (unique?) patterns that can confirm disease. Therefore, principal components analysis (PCA) was used to construct informative linear combinations of individual VOCs with high discriminatory power. A definite clustering of the presence of BC from cancer-free points was found; e.g. for C33, 18 of 24 controls clustered below 0 while all 8 cancer patients clustered above 0.1 (overall range -0.4 - 0.3). Conclusions: Our data show promising evidence that BC patients can be differentiated from healthy volunteers through distinct breath VOCs. We continue to accrue to this pilot study with the intent of developing portable collection and sensing devices that could have implications for women without access to standard screening; interval screening for patients at high risk for BC; and disease monitoring for BC patients after completion of treatment. No significant financial relationships to disclose.
Early NK Cell Proliferation After Umbilical Cord Blood Transplantation Is Associated With Superior Disease-Free Survival Due To Reduced Leukemia Relapse
Authors: Rachel Joy Bergerson, Sarah Cooley, Julie Curtsinger, Ryan Shanley, Claudio Brunstein, Bruce R Blazar, John E. Wagner, Jeffrey S. Miller, Michael R. Verneris
Journal: Blood (2013)
Book: Daniel Isn't Talking
Authors: Charles Essex
Journal: BMJ (2006)

Daniel Isn't Talking is about autism among the chattering classes, a novel that chronicles two ways of coping with a life changing diagnosis, and the breakdown of a marriage when a child has special educational needs.

Daniel's mother, Melanie, is pursuing every therapeutic option, usually privately, yet unquestioningly adopts unproven and expensive diets.

Daniel's father, on the other hand, is in denial; he wants the professionals to deal with this, and eventually leaves the family. Later, he wants to return and is willing to comply with all Melanie's views on Daniel. As a father and husband with a full time job I have some sympathy for him. Maternity and children's health professionals often exclude or ignore fathers, and then criticise them for being unsupportive.

The flyleaf (author) notes do not say that Marti Leimbach has a relative with special needs or has worked with families in these circumstances. It is perhaps remarkable, therefore, how she captures the quintessence of the so called caring services: professionals talking the talk and not walking the walk; some describing what they cannot do; others unable to resist offering treatment, however unnecessary (such as insoles to stop Daniel walking on tiptoes—so what if he walks on his toes?). She gets some details wrong (paediatricians wearing white coats and a paediatric neurologist with a white coat and a stetho-scope, none of which have I seen in over 20 years in paediatrics; and the speech therapist refusing to work with Daniel because he can't speak). There is no mention of the social services disability team, so Leimbach got that right.

I have heard numerous parents say that it is as stressful dealing with health, education, and social services as it is bringing up a child with severe learning disabilities. Leimbach captures these terrible indictments of the caring services without rancour.

The last third of the book is unsatisfactory and unrealistic. Daniel's Lovaas therapy (an intensive behaviour therapy approach for children with autism) seems to bring unbelievably good results. But the first two thirds of the book are worth four stars and should be required reading for everyone dealing with children with special needs.​needs.




Figure 1



Marti Leimbach

Fourth Estate, £10.99, pp 288 ISBN 0 00 721700 5

Rating: ★★★⋆
A Phase I Dose-Escalation Study of Carfilzomib in Patients with Previously-Treated Systemic Light-Chain (AL) Amyloidosis
Authors: Adam D. Cohen, Emma C. Scott, Michaela Liedtke, Jonathan L. Kaufman, Heather Landau, David H. Vesole, Christina L. Gomes, Cristina Gasparetto, Suzanne Lentzsch, Michael Rosenzweig, Vaishali Sanchorawala, David D. Smith, Raymond L. Comenzo, Brian G. M. Durie
Journal: Blood (2014)
Exercise tolerance can explain the obesity paradox in patients with systolic heart failure: data from the <scp>MECKI</scp> Score Research Group
Authors: Massimo F. Piepoli, Ugo Corrà, Fabrizio Veglia, Alice Bonomi, Elisabetta Salvioni, Gaia Cattadori, Marco Metra, Carlo Lombardi, Gianfranco Sinagra, Giuseppe Limongelli, Rosa Raimondo, Federica Re, Damiano Magrì, Romualdo Belardinelli, Gianfranco Parati, Chiara Minà, Angela B. Scardovi, Marco Guazzi, Mariantonietta Cicoira, Domenico Scrutinio, Andrea Di Lenarda, Maurizio Bussotti, Maria Frigerio, Michele Correale, Giovanni Quinto Villani, Stefania Paolillo, Claudio Passino, Piergiuseppe Agostoni
Journal: European Journal of Heart Failure (2016)
BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants
Authors: Dagfinn Aune, Abhijit Sen, Manya Prasad, Teresa Norat, Imre Janszky, Serena Tonstad, Pål Romundstad, Lars J Vatten
Journal: BMJ (2016)

<b>Objective</b>&nbsp;To conduct a systematic review and meta-analysis of cohort studies of body mass index (BMI) and the risk of all cause mortality, and to clarify the shape and the nadir of the dose-response curve, and the influence on the results of confounding from smoking, weight loss associated with disease, and preclinical disease. <b>Data sources</b>&nbsp;PubMed and Embase databases searched up to 23 September 2015. <b>Study selection</b>&nbsp;Cohort studies that reported adjusted risk estimates for at least three categories of BMI in relation to all cause mortality. <b>Data synthesis</b>&nbsp;Summary relative risks were calculated with random effects models. Non-linear associations were explored with fractional polynomial models. <b>Results</b>&nbsp;230 cohort studies (207 publications) were included. The analysis of never smokers included 53 cohort studies (44 risk estimates) with &gt;738 144 deaths and &gt;9 976 077 participants. The analysis of all participants included 228 cohort studies (198 risk estimates) with &gt;3 744 722 deaths among 30 233 329 participants. The summary relative risk for a 5 unit increment in BMI was 1.18 (95% confidence interval 1.15 to 1.21; I<sup>2</sup>=95%, n=44) among never smokers, 1.21 (1.18 to 1.25; I<sup>2</sup>=93%, n=25) among healthy never smokers, 1.27 (1.21 to 1.33; I<sup>2</sup>=89%, n=11) among healthy never smokers with exclusion of early follow-up, and 1.05 (1.04 to 1.07; I<sup>2</sup>=97%, n=198) among all participants. There was a J shaped dose-response relation in never smokers (P<sub>non-linearity</sub> &lt;0.001), and the lowest risk was observed at BMI 23-24 in never smokers, 22-23 in healthy never smokers, and 20-22 in studies of never smokers with ≥20 years’ follow-up. In contrast there was a U shaped association between BMI and mortality in analyses with a greater potential for bias including all participants, current, former, or ever smokers, and in studies with a short duration of follow-up (&lt;5 years or &lt;10 years), or with moderate study quality scores. <b>Conclusion</b>&nbsp;Overweight and obesity is associated with increased risk of all cause mortality and the nadir of the curve was observed at BMI 23-24 among never smokers, 22-23 among healthy never smokers, and 20-22 with longer durations of follow-up. The increased risk of mortality observed in underweight people could at least partly be caused by residual confounding from prediagnostic disease. Lack of exclusion of ever smokers, people with prevalent and preclinical disease, and early follow-up could bias the results towards a more U shaped association.
Germline heterozygous DDX41 variants in a subset of familial myelodysplasia and acute myeloid leukemia
Authors: S R Cardoso, G Ryan, A J Walne, A Ellison, R Lowe, H Tummala, A Rio-Machin, L Collopy, A Al Seraihi, Y Wallis, P Page, S Akiki, J Fitzgibbon, T Vulliamy, I Dokal
Journal: Leukemia (2016)

for the shorter RFS prediction, the contribution of MRD data to the multivariable model's accuracy was more pronounced than for the RFS model built initially (C-statistics of 0.78 and 0.65 for 6-and 12-month RFS without MRD data).As a caveat, there were only 18 events in the 6-month RFS analysis, limiting the inference that can be drawn from the multivariable models; larger cohorts will be needed to test this idea further.If confirmed, our studies may form the basis for the development of relatively accurate shorter-term RFS prediction models in which MRD data should be included.
The development of an outpatient chemotherapy medication safety program
Authors: J. R. Hoverman, D. Richardson, K. Hansen, P. C. Dugger, K. M. Shuey
Journal: Journal of Clinical Oncology (2006)

16005 Background: Through Institute of Medicine publications (To Err is Human) and through the public experience of a major cancer center, chemotherapy safety has been of concern. US Oncology, Inc. (USON) is the nations largest oncology management company, associated with over 900 medical, radiation, gynecologic and pediatric oncologists. In 2004 USON undertook a quality initiative with a principal objective a system-wide approach to medication safety. Methods: Medication safety was identified as a principal concern by a combined clinical/management committee. A questionnaire was prepared for each practice site to differentiate high performing practices in regards to variances from lower performing practices. 8 high performing practices and 8 lower performing practices were physically evaluated by team members. Neither the questionnaire nor onsite evaluation reliably differentiated quality processes. Three issues became apparent: no uniform reporting mechanism, multiple “double-check” interpretations and variable inclusion of medication safety into practice operations. The safety team undertook these first two issues. An online reporting tool was developed. “Double-check” was defined and processes mapped. Results: The team chose 1 st hour of chemotherapy as the denominator for medication occurrence reporting. An online reporting tool was developed with now 1 year of experience. 83% of practice sites are reporting, accounting for 445,148 1 st hours of chemotherapy. The occurrence rate is 0.66%. Of the total 0.13% is adverse drug reaction, 0.10% is near miss, 0.08% is miscalculation of dose, 0.05% is the wrong dose. Injury to a patient is a very rare event. Conclusions: The development of a culture of quality in an organization with affiliations of national scope is a formidable undertaking. These initial numbers have no comparative measure, as this is self-reporting using a novel denominator. However, there are within the network similar groups for comparison. The challenge continues to be developing a culture of reporting with systematic integration of those reports and quality processes into the fabric of the practice. [Table: see text]
Extended CCR5 Blockade in Graft-Versus-Host Disease Prophylaxis – a Phase II Study
Authors: Ran Reshef, James K. Mangan, Selina M. Luger, Alison Wakoff Loren, Elizabeth O. Hexner, Noelle V. Frey, Edward A. Stadtmauer, Robin E. Blauser, Lee P. Richman, Austin P. Huffman, Alex Ganetsky, Edward P. Acosta, James A. Hoxie, Rosemarie Mick, Robert H. Vonderheide, David L. Porter
Journal: Blood (2014)
NHS trusts are told to halt work on rotas and job offers to new doctors
Authors: Abi Rimmer
Journal: BMJ (2016)

NHS trusts, including foundation trusts, have been told to cease work relating to the introduction of a new junior doctor contract for five days as talks between the government and the BMA restart.

On Saturday 7 May the BMA agreed to re-enter negotiations with the government on a new contract for junior doctors in England. …
Hepatology at a Glance
Authors: Leanne Gentle, Imran Patanwala
Journal: Gut (2016)

Deepak Joshi, Geri Keane, Alison Brind ISBN: 978-1-118-75939-4, 128 pages, May 2015, Wiley-Blackwell

The ‘at a Glance’ series is a popular series of textbooks aimed at healthcare students and newly qualified practitioners. Hepatology-at-a-Glance offers bite-sized chapters, clear and concise in nature, to provide readers with a sound understanding of liver and biliary diseases, while also providing information on hepatobiliary anatomy and physiology.

The textbook is split into four main sections; ‘The Basics’ covering anatomy and physiology, ‘Evaluation of Liver Disease’ looking at history-taking, examination and diagnostics, ‘Clinical Scenarios’ outlining the main presentations of liver and biliary disease and finally ‘Diseases’ giving a double-page spread on a variety of conditions ranging from the common ‘bread and butter’ of hepatology to rare and more esoteric disorders.

From the point of view of a Foundation …
Oncogenic Wilms Tumor 1 (WT1) Mutation Augments Hematopoietic Progenitor Cell Clonogenicity and Promotes Expansion Of The Long-Term Hematopoietic Stem Cell (LT-HSC) Compartment: Implications For WT1-Mediated Leukemogenesis
Authors: Colleen E. Annesley, Rachel E. Rau, Daniel Magoon, David Loeb, Patrick Brown
Journal: Blood (2013)