tbuckley/cabot-search huggingface dataset:
Combination chemotherapy with paclitaxel, ifosfamide, and nedaplatin in the treatment for advanced or recurrent urothelial cancer
Authors: N. Shinohara, S. Suzuki, T. Harabayashi, M. Murakumo, K. Mitsuhashi, T. Demura, S. Nagamori, K. Nonomura
Journal: Journal of Clinical Oncology (2005)

4584 Background: The combination of methotrexate, vinblastine, doxorubicin, and cisplatin (MVAC) is the standard regimen for advanced urothelial cancer. However, MVAC produces durable improvements in survival in only a few patients, so that other therapeutic options are needed. We have developed a new regimen consisted of paclitaxel, ifosfamide, and nedaplatin (PIN) which was modified from the ITP regimen reported by Bajorin et al. The aim of the present study was to evaluate the efficacy of this PIN regimen in patients with advanced or recurrent urothelial cancer patients who have received prior cisplatin-based therapy. Methods: The PIN regimen consisted of paclitaxel 175 mg/m2 on day 1, ifosfamide 4.5 g/m2 divided over days 1,2 and 3, and nedaplatin 70 mg/m2 on day 1; PIN was given every 28 days. The doses of ifosfamide and nedaplatin were reduced according to the 24h creatinine clearance (24h CCr) value. Results: Twenty three patients were entered onto the study (median age, 66 years; median performance status, 1, median 24h CCr, 59ml/min, 19 patients with prior cisplatin-based chemotherapy and 4 patients treated as initial therapy). Metastatic sites at study entry included the lymph nodes (15), lung (7), soft tissue (8), bone (2), liver (2), and adrenal (1). Responses included 5 complete response and 14 partial response (overall response rate, 83%). Sixteen of 19 patients (84%) with prior chemotherapy responded versus 3 of 4 (75%) treated as initial therapy. The median duration of survival for patients with prior therapy was 22 months, compared with 13 months for patients treated as initial therapy. For all patients, the median time to progression and overall survival were 8 months (0–40+ months), and 22 months (2–42+ months), respectively. Twenty patients (87%) developed grade 4 neutropenia, with febrile neutropenia in 7 (30%). Grade 3–4 thrombocytopenia and anemia were seen in 6 and 3 patients, respectively. Grade 3 neuropathy was observed in 2 patients. There were no treatment-related deaths. Conclusions: The PIN regimen is highly active and produces objective durable responses even in patients previously treated with systemic chemotherapy for recurrent urothelial cancer. No significant financial relationships to disclose.
Current management of patients with severe acute peripartum cardiomyopathy: practical guidance from the Heart Failure Association of the European Society of Cardiology Study Group on peripartum cardiomyopathy
Authors: Johann Bauersachs, Mattia Arrigo, Denise Hilfiker‐Kleiner, Christian Veltmann, Andrew J.S. Coats, Maria G. Crespo‐Leiro, Rudolf A. De Boer, Peter van der Meer, Christoph Maack, Frederic Mouquet, Mark C. Petrie, Massimo F. Piepoli, Vera Regitz‐Zagrosek, Maria Schaufelberger, Petar Seferovic, Luigi Tavazzi, Frank Ruschitzka, Alexandre Mebazaa, Karen Sliwa
Journal: European Journal of Heart Failure (2016)
Transcendental meditation verus muscle relaxation: two-year follow-up of a controlled experiment
Authors: D C Zuroff, J C Schwarz
Journal: American Journal of Psychiatry (1980)

In this questionnaire survey the authors measured the outcome among 20 students randomly assigned to muscle relaxation training and 19 assigned to transcendental mediatation at one year (the number of respondents in each group was 13 and 16, respectively) and two and one-half years (the number of respondents was 18 and 17, respectively). At both follow-ups there were no differences between the groups in frequency of practice or satisfaction. In both groups, less than 25% reported more than moderate satisfaction, and less than 20% practices as mush as once per week. Subjects' expectancies at nine weeks predicted their satisfaction and frequency of practice at two and on-half years. The authors conclude that although some subjects (15%-20%) to enjoy and continue to practice transcendental meditation, it is not universally beneficial.
P-021 Tanshinone IIA can inhibit human pancreatic carcinoma BxPC3 cells through decreasing the protein expressions of IGFR, EGFR, VEGFR and blocking both Ras/Raf/MEK/ERK and Ras/PI3K/AKT/mTOR pathway in vitro and in vivo
Authors: C.C. Su
Journal: Annals of Oncology (2016)
Anti–Factor Xa Assay—A Changing Standard for Venous Thromboprophylaxis?
Authors: Kristin Cook, Massimo Napolitano, Frank T. Padberg
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Coronary artery surgery study (CASS): a randomized trial of coronary artery bypass surgery. Survival data.
Journal: Circulation (1983)

CASS includes a multicenter patient registry and a randomized controlled clinical trial. It is designed to assess the effect of coronary artery bypass surgery on mortality and selected nonfatal end points. From August 1975 to May 1979, 780 patients with stable ischemic heart disease were randomly assigned to receive surgical (n = 390) or nonsurgical (n = 390) treatment and were followed through April 15, 1983. At 5 years, the average annual mortality rate in patients assigned to surgical treatment was 1.1%. The annual mortality rate in those receiving medical therapy was 1.6%. Annual mortality rates in patients with single-, double-, and triple-vessel disease who were in the surgical group were 0.7%, 1.0%, and 1.5%; the corresponding rates in patients in the medical group were 1.4%, 1.2%, and 2.1%. The differences were not statistically significant. Nearly 75% of the patients had entry ejection fractions of at least 0.50. The annual mortality rates in patients in the surgical group in this subgroup with single-, double-, and triple-vessel disease were 0.8%, 0.8%, and 1.2% and corresponding rates in the medical group were 1.1%, 0.6%, and 1.2%. The annual rate of bypass surgery in patients who were initially assigned to receive medical treatment was 4.7%. The excellent survival rates observed both in CASS patients assigned to receive medical and those assigned to receive surgical therapy and the similarity of survival rates in the two groups of patients in this randomized trial lead to the conclusion that patients similar to those enrolled in this trial can safely defer bypass surgery until symptoms worsen to the point that surgical palliation is required.
Multiplicity of Cell Response to the BAI Strain A (Myeloblastosis) Avian Tumor Virus. III. Histologic Alteration and Adenosinetriphosphatase Activity of the Thymus of Chickens With Myeloblastosis<xref ref-type="fn" rid="FN1">2</xref>
Authors: L. Arvy, J.R. Sommer, Guy de Thé, Ursula Heine, Hideo Ishiguro, Dorothy Beard, J.W. Beard
Journal: JNCI Journal of the National Cancer Institute (1963)

Gross and histologic features and cytochemical reaction of the thymus and other organs and tissues of chickens with myeloblastic leukemia were studied. The normal population of lymphocytic cells of the cortex was replaced by blastlike elements. These cells appeared to originate in small foci in the cortex and they pervaded the cortical tissue in an orderly, uniform manner. There was no enlargement of the gland or other evidence of neoplastic change. The medulla was not altered. A marked adenosinetriphosphatase reaction, related to enzyme activity at the cytoplasmic membrane of the blastlike cells, was observed in the cortex. Alternations of cell population and ezymatic reaction analogous to those of the thymus were not shown by the tissue of the bursa of Fabricius, spleen, or other organs examined. Similar studies of birds with erythroblastosis did not reveal the phenomena observed in myeloblastosis. The possible origin and nature of the blastlike cortical cells are discussed.
Epidémie de brucellose liée à du fromage de chèvre non pasteurisé en Andalousie (Espagne), janvier-mars 2002
Authors: C. Mendez Martinez, A Paez Jimenez, M Cortés-Blanco, E. Salmoral Chamizo, E. Mohedano Mohedano, C. Plata, A. Varo Baena, J. F. Martinez Navarro
Journal: Eurosurveillance (2003)

Onze cas de brucellose ont ete identifies dans deux municipalites de Cordoba (Andalousie, Espagne). Une etude cas-temoins a ete menee en prenant trois cas pour un temoin. Les cas avaient consomme du fromage non pasteurise produit dans une ferme situee dans la zone epidemique et presentaient un risque plus eleve de contracter la brucellose que les temoins ( OR = 21.6, IC95% = 1.6-639.8). Brucella melitensis serovar 3 a ete identifie dans des prelevements cliniques, des tissus de chevre et des echantillons de lait provenant du troupeau de la ferme. Des mesures preventives ont ete mises en place et l'epidemie s'est termine apres que tous les fromages suspects aient ete retires du marche. Des mesures d'hygiene plus importantes ont ete instaurees a la ferme, ainsi que des actions de promotion de la sante.
Vitamin D and antimicrobial peptide levels in patients with atopic dermatitis and atopic dermatitis complicated by eczema herpeticum: A pilot study
Authors: Lujain H. Albenali, Simon Danby, Manar Moustafa, Kirsty Brown, John Chittock, Fiona Shackley, Michael J. Cork
Journal: Journal of Allergy and Clinical Immunology (2016)
Don’t dismiss pioglitazone on basis of uncertain risk
Authors: Alison Gallagher, Peter H Winocour
Journal: BMJ (2016)

Tuccori and colleagues conclude that the use of pioglitazone is associated with increased risk of bladder cancer.1 However, in this study pioglitazone and non-pioglitazone users were not matched and, despite adjustment, pioglitazone users were older, had type 2 diabetes for longer, and had worse glycaemic control than non-pioglitazone users.2

It is worrying …
Mammalian Chromosomes <italic>In Vitro</italic>. XV. Patterns of Transformation<xref ref-type="fn" rid="FN1">2</xref>
Authors: T. C. Hsu, Daniel Billen, Albert Levan
Journal: JNCI Journal of the National Cancer Institute (1961)

The chromosome constitution of a number of cell strains derived from mouse tissues was studied in detail. Strains H1a, H1b, H1e, and H4a were heteroploid (with chromosome numbers in the subtetraploid range) when the first samples were taken. At that time they were 9 to 11 months of age in vitro. Strain H4c, initiated and sampled at the same time as strain H4a, was primarily diploid. Strain H2 was principally diploid 5 months after its primary cultivation. In its control line, H2c, tetraploid, and later subtetraploid, cells gradually gained dominance and became the stemline. In populations of strain H2, treated intermittently with 5-bromodeoxyuridine, polyploidization was accelerated in one line (H2a). In another line, H2b, a temporary reversion to near diploid (s = 38) was noted. However, cells in the subtetraploid region finally became the stemline also. Thus heteroploid transformation may undergo the following 2 patterns: diploidy-tetraploidy-hypotetraploidy and diploidy-subdiploidy-hypotetraploidy. Structural changes of chromosomes were constantly observed in all cell lines, especially those with heteroploid stemline. Most biarmed chromosomes had equal arms, suggestive of isochromosome formation. However, few, if any, metacentrics were incorporated into the stemlines of the strains analyzed. The thymidine analogue, 5-bromodeoxyuridine, induces chromosome breakages and accelerates polyploidization.
Anti-Lymphoma Activity of Interferon-Free Antiviral Treatment in Patients with Indolent B-Cell Lymphomas Associated with Hepatitis C Virus Infection
Authors: Luca Arcaini, Caroline Besson, Jan Peveling-Oberhag, Véronique Loustaud-Ratti, Sara Rattotti, Virginia Ferretti, Anna Linda Zignego, Milvia Casato, Michele Merli, Olivier Hermine, Carlo Visco
Journal: Blood (2015)
Urban–rural differences of age- and species-specific campylobacteriosis incidence, Hesse, Germany, July 2005 – June 2006
Authors: J Fitzenberger, H Uphoff, S Gawrich, A M Hauri
Journal: Eurosurveillance (2010)

Campylobacter infection is the most common cause of bacterial gastroenteritis worldwide. This study examines the association between campylobacteriosis incidence and degree of urbanicity in Hesse, Germany, by age and Campylobacter species. During a one-year period (July 2005–June 2006), Hessian local health authorities provided information on municipality of residence for 3,315 campylobacteriosis cases. We calculated age- and Campylobacter species-specific incidences for six levels of urbanicity, as defined by population density and accessibility of centres. For children under five years old, living in inner rural areas (incidence rate ratio (IRR): 2.9; 95% confidence interval (CI): 1.9 to 4.4) and for children aged 5–14 years living in inner rural (IRR: 2.1; 95% CI: 1.3 to 3.1) or intermediate areas (inner intermediate area IRR: 1.8; 95% CI: 1.2 to 2.7; outer intermediate area IRR: 2.1; 95% CI: 1.3 to 3.3) was associated with a statistically significantly higher campylobacteriosis risk (reference category: inner urban area). Calculations by Campylobacter species showed a higher risk of gastroenteritis due to C. coli for inhabitants (all ages) of non-urban areas. This study suggests that differences in risk factors by age, Campylobacter species and degree of urbanicity do exist. For children contact with animals or the environment may be responsible for a substantial proportion of sporadic Campylobacter infections.
Effects of Multiple Myeloma (MM) Therapy and Type of Thromboprophylaxis On the Incidence and Timing of Venous Thromboembolism (VTE) and Factors Predictive of VTE.
Authors: Jatin J. Shah, Aparna Hegde, Xiao Zhou, Sheeba K. Thomas, Michael Wang, Donna M. Weber, Raymond Alexanian, Robert Z. Orlowski, Saroj Vadhan-Raj
Journal: Blood (2012)
Delineation of Spatial Variability in the Temperature–Mortality Relationship on Extremely Hot Days in Greater Vancouver, Canada
Authors: Hung Chak Ho, Anders Knudby, Blake Byron Walker, Sarah B. Henderson
Journal: Environmental Health Perspectives (2016)

Climate change has increased the frequency and intensity of extremely hot weather. The health risks associated with extemely hot weather are not uniform across affected areas owing to variability in heat exposure and social vulnerability, but these differences are challenging to map with precision.We developed a spatially and temporally stratified case-crossover approach for delineation of areas with higher and lower risks of mortality on extremely hot days and applied this approach in greater Vancouver, Canada.Records of all deaths with an extremely hot day as a case day or a control day were extracted from an administrative vital statistics database spanning the years of 1998-2014. Three heat exposure and 11 social vulnerability variables were assigned at the residential location of each decedent. Conditional logistic regression was used to estimate the odds ratio for a 1°C increase in daily mean temperature at a fixed site with an interaction term for decedents living above and below different values of the spatial variables.The heat exposure and social vulnerability variables with the strongest spatially stratified results were the apparent temperature and the labor nonparticipation rate, respectively. Areas at higher risk had values ≥ 34.4°C for the maximum apparent temperature and ≥ 60% of the population neither employed nor looking for work. These variables were combined in a composite index to quantify their interaction and to enhance visualization of high-risk areas.Our methods provide a data-driven framework for spatial delineation of the temperature--mortality relationship by heat exposure and social vulnerability. The results can be used to map and target the most vulnerable areas for public health intervention. Citation: Ho HC, Knudby A, Walker BB, Henderson SB. 2017. Delineation of spatial variability in the temperature-mortality relationship on extremely hot days in greater Vancouver, Canada. Environ Health Perspect 125:66-75; http://dx.doi.org/10.1289/EHP224.
Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody
Authors: Emanuela Pupo, Nadia Ducano, Barbara Lupo, Elisa Vigna, Daniele Avanzato, Timothy Perera, Livio Trusolino, Letizia Lanzetti, Paolo M. Comoglio
Journal: Cancer Research (2016)

MET oncogene amplification is emerging as a major mechanism of acquired resistance to EGFR-directed therapy in lung and colorectal cancers. Furthermore, MET amplification predicts responsiveness to MET inhibitors currently in clinical trials. Among the anti-MET drugs available, ATP-competitive small-molecule kinase inhibitors abrogate receptor autophosphorylation and downstream activation of ERK1/2 and AKT, resulting in cell-cycle arrest. However, this antiproliferative effect allows persistence of a pool of cancer cells that are quiescent but alive. Once the inhibition is removed, rebound activation of MET-driven cell proliferative pathways and tumor growth may occur, an adverse event observed frequently in clinical settings after drug discontinuation. Here we show that inhibitor withdrawal prompts receptor phosphorylation to levels higher than those displayed at steady-state and generates a rebound effect pushing quiescent cancer cells back into the cell cycle, both in vitro and in experimental tumor models in vivo Mechanistically, we found that inhibitor treatment blocks MET endocytosis, causing a local increase in the number of receptors at the plasma membrane. Upon inhibitor washout, the receptor is readily rephosphorylated. The initial phosphorylation is not only increased but also prolonged in duration due to downmodulation of a phosphatase-mediated MET-negative feedback loop, which accompanies receptor internalization. Notably, treatment with a MET therapeutic antibody that induces proteolytic cleavage of the receptor at the cell surface substantially prevents this rebound effect, providing a rationale to combine or alternate these mechanistically different types of MET-targeted therapy. Cancer Res; 76(17); 5019-29. ©2016 AACR.
Many Mansions
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Severe hypertension in children with renovascular disease.
Authors: HENNY BROEKHUIZEN-DE GAST, MONIQUE C. TIEL-VAN BUUL, EDROIN R. VAN BEEK
Journal: Clinical Nuclear Medicine (2001)

Renovascular disease is an important cause of hypertension in children and is associated with considerable morbidity and mortality risks. Secondary hypertension is more common in children than in adults, with children accounting for 75% to 80% of cases. In 70% of secondary hypertension in children, the cause is fibromuscular hyperplasia. Other associated conditions are aorto-aortitis, the midaortic syndrome, and Williams-Bueren syndrome. Imaging techniques have an important role in the early discovery of renal artery stenosis. Although renal arteriography remains the definitive method, noninvasive and less invasive radiographic procedures such as ultrasonography with duplex Doppler scanning and radionuclide scintigraphy have been used as adjunct diagnostic tools in children. The authors describe three young children with renovascular hypertension in whom dynamic radionuclide scintigraphy with Tc-99m MAG3 played an essential role in the diagnosis of renovascular hypertension.
Whatever Happened to Psychiatry? The Deprofessionalization of Community Mental Health Centers
Authors: Paul J. Fink, Stephen P. Weinstein
Journal: American Journal of Psychiatry (1979)

The authors describe the dichotomy in the concept of community mental health centers. One view regards the community mental health center as a service provider for underserved populations, and another holds that it is an agent of social change. Deprofessionalization of community mental health centers has resulted from this lack of clear purpose, curtailment of funds, and conflicts over authority, service delivery, and control of the centers. Deprofessionalization has led to a decline in the number of psychiatrists in community mental health centers and a potentially negative impact on the quality of patient care.
Myocardial Ischemia
Authors: Gerd Heusch
Journal: Circulation Research (2016)

Regional myocardial blood flow and contractile function in ischemic myocardium are well matched, and there is no evidence for an oxygen supply/demand imbalance. Thus, myocardial ischemia is lack of coronary blood flow with electric, functional, metabolic, and structural consequences for the myocardium. All therapeutic interventions must aim to improve blood flow to ischemic myocardium as much and as quickly as possible.
The Major Phagocyte Peroxidase-Derived Oxidant, HOSCN (Hypothiocyanous Acid), Induces Proinflammatory and Cytoprotective Gene Expression in Endothelium: A Mechanism for Microlocalized Regulation of Inflammation.
Authors: Shawn A. Mahmud, Jian-Guo Wang, Peng Wei, Molly S. Thomas, John D. Belcher, Gregory M. Vercellotti, Arne Slungaard
Journal: Blood (2007)
MPs condemn lack of rigour in how UK’s £6bn science budget is spent
Authors: Matthew Limb
Journal: BMJ (2016)

The government is not doing enough to ensure that £6bn (€7.3bn; $8bn) of science funding benefits the UK economy and goes to the right projects, a committee of MPs has concluded.

The House of Commons Public Accounts Committee has called for more robust assessment of proposals and better protection for the intellectual property that results from taxpayers’ investment. The committee’s report, Capital Investment in Science Projects , was published on 29 June.1

Meg Hillier, chair of the committee, said, “We are not convinced that there is sufficient rigour and transparency in the way funding decisions are made, nor enough attention paid to safeguarding the benefits resulting from those decisions.”

The committee said that ministers announcing …