tbuckley/cabot-search huggingface dataset:
LG-05INCIDENTALLY FOUND CNS LESIONS IN PEDIATRICS: ADDRESSING A CURRENT TREATMENT DILEMMA
Authors: Erin Wright, Steven Winesett, Ernest Amankwah, Stacie Stapleton
Journal: Neuro-Oncology (2016)

LG-05. INCIDENTALLY FOUND CNS LESIONS IN PEDIATRICS: ADDRESSING A CURRENT TREATMENT DILEMMA Erin Wright2, Steven Winesett1, Ernest Amankwah1, and Stacie Stapleton1; AllChildren’sHospital, St. Petersburg,FL,USA; AkronChildren’sHospital, Akron, OH, USA Increased frequency of imaging in the pediatric population has led to an increase in the number of incidentally found CNS lesions. These lesions are a treatment dilemma for physicians and cause emotional strain for patients and families. Adult population data support initial surveillance of these incidentally found low grade lesions; however, similar pediatric research has been relatively limited due to sample size. Pediatric records were reviewed at All Children’s Hospital, a tertiary free-standing children’s hospital, for incidentally found CNS lesions. Demographic data, presenting symptoms, treatment approach, and outcomes were reviewed for 55 patients. Seventeen patients had biopsies or excision upon diagnosis due to imaging characteristics concerning for a high grade lesion. Thirty-nine patients underwent radiographic observation (average 35.5 months) and only 1 patient went on to require surgical intervention. Surgical pathology showed only one high grade lesion (ependymoma WHO grade 3) of those who underwent surgical evaluation. The presenting symptoms of a majority of the patients (67%) were headache, trauma, syncope, and seizure. The majority of the lesions were located in the posterior fossa (28/55). Of the 39 study patients that were monitored radiographically only 7 showed an increase in the overall size of the lesion and only 1 required surgical intervention. The remaining patients showed stable disease or spontaneous improvement. This data represents a large single center study that significantly contributes to prior published data and further supports surveillance as the best initial management of incidentally found lesions in the pediatric population. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.5 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Case 16-1979
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Michael N. Margolies, Robert H. Young
Journal: New England Journal of Medicine (1979)

Presentation of CaseA 61-year-old man was admitted to the hospital because of bleeding per rectum.Seven years earlier chronic diarrhea developed, associated with dull pain in the left lower quadrant of the abdomen. Four years before admission he entered another hospital, where laboratory studies disclosed that the pH of the gastric juice was 7.5; free acid was absent, and the total acid 15 units. In a 24-hour specimen of urine the 5-hydroxyindoleacetic acid (5-HIAA) was 2.1 mg. Proctoscopic examination to 25 cm disclosed that the mucosa bled easily but otherwise appeared normal. A biopsy of the rectal mucosa revealed . . .
Urinary Excretion of Corticosteroids in Guinea Pigs With malignant Neoplastic Diseases&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: S BURSTEIN, E M NADEL
Journal: JNCI Journal of the National Cancer Institute (1956)

Urinary Excretion of Corticosteroids in Guinea Pigs With malignant Neoplastic Diseases Eli M. Nadel, Eli M. Nadel Search for other works by this author on: Oxford Academic PubMed Google Scholar Shlomo Burstein Shlomo Burstein Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 2, August 1956, Pages 213–220, https://doi.org/10.1093/jnci/17.2.213 Published: 01 August 1956 Article history Received: 23 April 1956 Published: 01 August 1956
Serodiscordance in chronic Chagas disease diagnosis: a real problem in non-endemic countries
Authors: Z. Moure, A. Angheben, I. Molina, F. Gobbi, M. Espasa, M. Anselmi, F. Salvador, S. Tais, A. Sánchez-Montalvá, T. Pumarola, P. Albajar-Viñas, E. Sulleiro
Journal: Clinical Microbiology and Infection (2016)
Capsaicin-evoked cough responses in asthmatic patients: Evidence for airway neuronal dysfunction
Authors: Imran Satia, Nikolaos Tsamandouras, Kimberley Holt, Huda Badri, Mark Woodhead, Kayode Ogungbenro, Timothy W. Felton, Paul M. O'Byrne, Stephen J. Fowler, Jaclyn A. Smith
Journal: Journal of Allergy and Clinical Immunology (2016)

Cough in asthmatic patients is a common and troublesome symptom. It is generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness and inflammation, but the possibility that airway nerves are dysfunctional has not been fully explored.We sought to investigate capsaicin-evoked cough responses in a group of patients with well-characterized mild-to-moderate asthma compared with healthy volunteers and assess the influences of sex, atopy, lung physiology, inflammation, and asthma control on these responses.Capsaicin inhalational challenge was performed, and cough responses were analyzed by using nonlinear mixed-effects modeling to estimate the maximum cough response evoked by any concentration of capsaicin (Emax) and the capsaicin dose inducing half-maximal response (ED50).Ninety-seven patients with stable asthma (median age, 23 years [interquartile range, 21-27 years]; 60% female) and 47 healthy volunteers (median age, 38 years [interquartile range, 29-47 years]; 64% female) were recruited. Asthmatic patients had higher Emax and lower ED50 values than healthy volunteers. Emax values were 27% higher in female subjects (P = .006) and 46% higher in patients with nonatopic asthma (P = .003) compared with healthy volunteers. Also, patients with atopic asthma had a 21% lower Emax value than nonatopic asthmatic patients (P = .04). The ED50 value was 65% lower in female patients (P = .0001) and 71% lower in all asthmatic patients (P = .0008). ED50 values were also influenced by asthma control and serum IgE levels, whereas Emax values were related to 24-hour cough frequency. Age, body mass index, FEV1, PC20, fraction of exhaled nitric oxide, blood eosinophil counts, and inhaled steroid treatment did not influence cough parameters.Patients with stable asthma exhibited exaggerated capsaicin-evoked cough responses consistent with neuronal dysfunction. Nonatopic asthmatic patients had the highest cough responses, suggesting this mechanism might be most important in type 2-low asthma phenotypes.
Withdrawing low risk women from cervical screening programmes
Authors: M E van den Akker-van Marle, M van Ballegooijen, R Boer, G J van Oortmarssen, J D F Habbema, C. Sherlaw-Johnson, S. Gallivan, D. Jenkins
Journal: BMJ (1999)

Children born after intracytoplasmic sperm injection What do authors mean by control infants?Editor-Sutcliffe et al compare babies born through intracytoplasmic sperm injection with control babies (matched for social class, maternal education, region, and sex) born after unassisted conception. 1 In their table they give means, standard deviations, and 95% confidence intervals for the two groups separately.These confidence intervals tell us about the estimation of the mean in the population of which the babies are a random sample, which they are not.They tell us nothing about the comparison between the cases and controls.These controls have been chosen to be similar to the study babies in many ways; they are not a representative sample of babies.It is the difference between the study babies and the control babies that is of interest, and the confidence interval we should have is that for this difference in mean.We cannot work this out from the data given, because this is a paired study and we have unpaired standard deviations.All we have for the comparison is the implication, not actually stated, that the differences are not significant.What we should be given are confidence intervals that tell us how different the cases and controls are.
Detection of a Hypervariable DNA Locus in Birds by Hybridization with a Mouse MHC Probe
Authors: H Gibbs, Peter Boag, Bradley White, Patrick Weatherhead, Lisa Tabak
Journal: Molecular Biology and Evolution (1991)

The identification of broad classes of DNA probes which detect hypervariable genetic markers in different taxa is invaluable for parentage analysis in wild vertebrates.Restriction-fragment-length polymorphisms, detected by hybridization of a mouse class II major histocompatibility complex (MHC) cDNA probe to genomic DNA from red-winged blackbirds (Ageluius phoeniceus), are shown to have the genetic characteristics of a single hypervariable locus with many codominant alleles.Surveys of DNA from unrelated individuals that was cut with a single restriction enzyme (EcoRI) revealed a large number (37) of resolvable alleles with a low mean frequency (P = 0.02 I ).When RFLP data from multiple enzymes are combined with segregation data, individual-specific haplotypes can be generated.These characteristics make this probe ideal for parentage analysis in this and other blackbird species.The many MHC probes available from mice and humans may provide a valuable source of hypervariable single-locus genetic markers, precluding the necessity of isolating species-specific probes from genomic libraries.
The Water Quality in Rio Highlights the Global Public Health Concern Over Untreated Sewage
Authors: Joseph N.S. Eisenberg, Jamie Bartram, Timothy J. Wade
Journal: Environmental Health Perspectives (2016)

Summary:Water quality issues in Rio have been widely publicized because of the 2016 Olympics. Recent concerns about polluted waters that athletes may be exposed to highlights the conditions that more than a billion people globally are exposed to daily. Despite these unhealthy conditions, much is unknown about the risks and exposure pathways associated with bathing in or drinking untreated or partially treated sewage. Beyond acute illness, we are learning more about the chronic sequelae that arise from repeated exposure to pathogens found in sewage. Additionally, we do not know enough about how to measure water quality, especially in developing countries. A consequence of these knowledge gaps is that data from developed countries are used to guide public health approaches in low- and middle-income settings. More data that are locally specific are needed to inform guidelines for improving sanitation and water quality in Rio and other cities in developing countries.
LMI-07HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR CENTRAL NERVOUS SYSTEM TUMORS: A SINGLE CENTER EXPERIENCE
Authors: Victor Zecchin, Andrea Cappellano, Nasjla Saba, Sergio Cavalheiro, Patricia Dastoli, Ana Cristina Mendonca, Renata Guimaraes, Virginio Fernandes Junior, Cintia Monteirio, Adriane Ibanez, Leticia Ribeiro
Journal: Neuro-Oncology (2016)

LMI-07. HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR CENTRAL NERVOUS SYSTEM TUMORS: A SINGLE CENTER
QOS-30FUNCTIONAL INDEPENDENCE IN ADULT SURVIVORS OF PEDIATRIC CNS TUMORS: A REPORT FROM THE ST. JUDE LIFETIME COHORT STUDY
Authors: Tara Brinkman, Kirsten Ness, Zhenghong Li, Kevin Krull, Amar Gajjar, Thomas Merchant, Fredrick Boop, Paul Klimo, Raja Khan, Deokumar Srivastava, Leslie Robison, Melissa Hudson, Gregory Armstrong
Journal: Neuro-Oncology (2016)
HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer Cells
Authors: Helen Sadik, Preethi Korangath, Nguyen K. Nguyen, Balazs Gyorffy, Rakesh Kumar, Mohammad Hedayati, Wei Wen Teo, Sunju Park, Hardik Panday, Teresa Gonzalez Munoz, Otilia Menyhart, Nilay Shah, Raj K. Pandita, Jenny C. Chang, Theodore DeWeese, Howard Y. Chang, Tej K. Pandita, Saraswati Sukumar
Journal: Cancer Research (2016)

Abstract Development of drug resistance is a major factor limiting the continued success of cancer chemotherapy. To overcome drug resistance, understanding the underlying mechanism(s) is essential. We found that HOXC10 is overexpressed in primary carcinomas of the breast, and even more significantly in distant metastasis arising after failed chemotherapy. High HOXC10 expression correlates with shorter recurrence-free and overall survival in patients with estrogen receptor–negative breast cancer undergoing chemotherapy. We found that HOXC10 promotes survival in cells treated with doxorubicin, paclitaxel, or carboplatin by suppressing apoptosis and upregulating NF-κB. Overexpressed HOXC10 increases S-phase–specific DNA damage repair by homologous recombination (HR) and checkpoint recovery in cells at three important phases. For double-strand break repair, HOXC10 recruits HR proteins at sites of DNA damage. It enhances resection and lastly, it resolves stalled replication forks, leading to initiation of DNA replication following DNA damage. We show that HOXC10 facilitates, but is not directly involved in DNA damage repair mediated by HR. HOXC10 achieves integration of these functions by binding to, and activating cyclin-dependent kinase, CDK7, which regulates transcription by phosphorylating the carboxy-terminal domain of RNA polymerase II. Consistent with these findings, inhibitors of CDK7 reverse HOXC10-mediated drug resistance in cultured cells. Blocking HOXC10 function, therefore, presents a promising new strategy to overcome chemotherapy resistance in breast cancer. Cancer Res; 76(15); 4443–56. ©2016 AACR.
Reversing the oncogenic roles of misdirected chromatin remodeling: Mechanistic insights into the SS18-SSX fusion protein in synovial sarcoma.
Authors: Cigall Kadoch, Gerald R. Crabtree
Journal: Journal of Clinical Oncology (2013)

10515 Background: Synovial sarcoma (SS) accounts for ~10% of soft-tissue malignancies and is generally resistant to chemotherapy-based approaches, underscoring the need for a mechanistic understanding of its pathogenesis and the development of disease-specific biologic agents. The hallmark molecular feature is a precise and uniform translocation, t(X;18), which results in the fusion of exactly 78 amino acids of SSX to the SS18 C-terminus. Because the SS18-SSX genetic lesion is observed in 100% of cases, it is likely the driving oncogenic event in these tumors; however, the molecular basis for its role in oncogenesis is undefined. Methods: We performed an affinity purification-/mass spectrometry-based analysis of endogenous mSWI/SNF (BAF) chromatin remodeling complexes in several primary cell types. Using these data in combination with protein biochemical methods, we discovered that SS18 is a dedicated, non-exchangeable subunit of these complexes with a binding affinity comparable to that of ribosomal subunits. Subsequent biochemical and functional investigations were performed to assess the oncogenic consequences of addition of 78aa of SSX to the SS18 subunit in SS. Results: We demonstrate that the SS18-SSX fusion incorporates into BAF complexes, evicting both wild-type (WT) SS18 and the tumor suppressor subunit, hSNF5 (BAF47), known to be biallelically inactivated in pediatric malignant rhabdoid tumors (MRTs). The altered complex binds the Sox2 locus, reversing polycomb-mediated repression and activating Sox2. Sox2, a pro-pluripotency transcription factor, is uniformly expressed in SS tumors and is essential for proliferation. Remarkably, increasing the concentration of WT SS18 leads to reassembly of WT complexes, retargeting of BAF complexes, returned polycomb-mediated repression at the Sox2 locus and cessation of SS cell proliferation. This mechanism of transformation depends on a region of only two amino acids of SSX, and hence provides a strong foundation for therapeutic intervention. Conclusions: These studies provide a novel oncogenic mechanism for SS tumors and inform strategies for therapeutic development in this intractable cancer.
Outcomes of Patients with Chronic Phase CML Who Discontinued Ponatinib in the Frontline Setting
Authors: Preetesh Jain, Hagop M Kantarjian, Elias Jabbour, Zeev Estrov, Gautam Borthakur, Naveen Pemmaraju, Tapan Kadia, Naval Daver, Farhad Ravandi, Srdan Verstovsek, Susan O'Brien, Jorge E. Cortes
Journal: Blood (2015)
300. Long-Term Transgene Expression in NewBorn Cynomolgus Macaques Following IntraUterine Gene Transfer of Self-Complementary AAV
Authors: Citra N. Mattar, Niraja M. Dighe, Simon N. Waddington, Jenny McIntosh, Arjit Biswas, Nicholas M. Fisk, Andrew M. Davidoff, Amit C. Nathwani, Mahesh A.A Choolani, Jerry Chan
Journal: Molecular Therapy (2009)
MB-11RESTRICTING GROWTH AND SPREADING OF MEDULLOBLASTOMA BY BLOCKING KINASE-DEPENDENT BRAIN INFILTRATION
Authors: Dimitra Tripolitsioti, Anuja Neve, Karthiga Santhana Kumar, Gustavo Alencastro Veiga Cruzeiro, Elena Alvarez, Tarek Shalaby, Michael Grotzer, Martin Baumgartner
Journal: Neuro-Oncology (2016)
Treatment of rhabdomyosarcoma.
Authors: B M Camitta
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.1.323 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8558216 Treatment of rhabdomyosarcoma. B M CamittaxB M CamittaSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.1.323 PDF "Treatment of rhabdomyosarcoma.." Journal of Clinical Oncology, 14(1), p. 323© 1996 by American Society of Clinical Oncology
Molecular Pathways: Targeting DNA Repair Pathway Defects Enriched in Metastasis
Authors: Niall M. Corcoran, Michael J. Clarkson, Ryan Stuchbery, Christopher M. Hovens
Journal: Clinical Cancer Research (2016)

The maintenance of a pristine genome, free from errors, is necessary to prevent cellular transformation and degeneration. When errors in DNA are detected, DNA damage repair (DDR) genes and their regulators are activated to effect repair. When these DDR pathways are themselves mutated or aberrantly downregulated, cancer and neurodegenerative disorders can ensue. Multiple lines of evidence now indicate, however, that defects in key regulators of DNA repair pathways are highly enriched in human metastasis specimens and hence may be a key step in the acquisition of metastasis and the ability of localized disease to disseminate. Some of the key regulators of checkpoints in the DNA damage response are the TP53 protein and the PARP enzyme family. Targeting of these pathways, especially through PARP inhibition, is now being exploited therapeutically to effect significant clinical responses in subsets of individuals, particularly in patients with ovarian cancer or prostate cancer, including cancers with a marked metastatic burden. Targeting DNA repair-deficient tumors with drugs that take advantage of the fundamental differences between normal repair-proficient cells and repair-deficient tumors offers new avenues for treating advanced disease in the future. Clin Cancer Res; 22(13); 3132-7. ©2016 AACR.
Increase in Incidence of Lung Tumors in Strain a Mice Following Long-Continued Irradiation with Gamma Rays
Authors: Egon Lorenz, Walter E. Heston, Margaret K. Deringer, Allen B. Eschenbrenner
Journal: JNCI Journal of the National Cancer Institute (1946)

Increase in Incidence of Lung Tumors in Strain a Mice Following Long-Continued Irradiation with Gamma Rays Get access Egon Lorenz, Egon Lorenz senior biophysicist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Walter E. Heston, Walter E. Heston senior geneticist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer, Margaret K. Deringer research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Allen B. Eschenbrenner Allen B. Eschenbrenner surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 6, Issue 6, June 1946, Pages 349–353, https://doi.org/10.1093/jnci/6.6.349 Published: 01 June 1946
RA-05NEUROIMAGING AND EVENTUAL ETIOLOGY OF CHILDREN WITH IDIOPATHIC THICKENED PITUITARY STALK (ITPS) AND/OR IDIOPATHIC CENTRAL DIABETES INSIPIDUS (ICDI): A SINGLE CENTER EXPERIENCE ON 53 CHILDREN PRESENTING OVER 30 YEARS
Authors: Manuela Cerbone, Ash Ederies, Laura Losa, Carolina Moreno, Helen A. Spoudeas
Journal: Neuro-Oncology (2016)
Failure of Intensified Induction Therapy and Inability to Undergo Stem Cell Transplantation Predict Dismal Outcomes in Relapsed/Refractory MYC+ B-Cell Lymphoma
Authors: Ryan D. Cassaday, Philip A. Stevenson, Bronwyn H. Bryant, Cecilia Yeung, Brian G. Till, Stephen D. Smith, Edward N. Libby, Andrei R. Shustov, John M. Pagel, Damian J. Green, Mary Philip, Johnnie J. Orozco, Min Fang, Leona Holmberg, William I. Bensinger, David G Maloney, Ajay K. Gopal, Oliver W. Press
Journal: Blood (2014)
Physicochemical Characteristics of the Tumor-Necrotizing Agent from &lt;italic&gt;Serratia marcescens&lt;/italic&gt; (Shear's Polysaccharide)&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: H MALMGREN
Journal: JNCI Journal of the National Cancer Institute (1954)

Physicochemical Characteristics of the Tumor-Necrotizing Agent from Serratia marcescens (Shear's Polysaccharide) Get access Harry Malmgren, Ph.D. Harry Malmgren, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 5, April 1954, Pages 1119–1122, https://doi.org/10.1093/jnci/14.5.1119 Published: 01 April 1954 Article history Received: 21 August 1953 Published: 01 April 1954
MB-47RISK OF HIPPOCAMPAL REGION METASTASIS IN HIGH RISK MEDULLOBLASTOMA: SUFFICIENT RATIONAL FOR HIPPOCAMPAL SPARING DURING CRANIOSPINAL IRRADIATION?
Authors: Laetitia Padovani, Frederique Chapon, Anne Geoffray, Line Claude, Aymeri Huchet, Anne Laprie, Bernard Coche Dequeant, Chrisitne Kerr, Claire Alapetite, Julie Leseur, Sophie Chapet, Valerie Bernier, Pierre Yves Bondiau, Georges Noel, Nicolas Andre, François Doz, Christian Carrie, Christelle Dufour, Xavier Muracciole
Journal: Neuro-Oncology (2016)
Tolerating Hepatitis
Authors: George Grady
Journal: New England Journal of Medicine (1974)

The report of Chatterjee et al. on pages 62–65 not only confirms that hepatitis B is generally well tolerated by renal-transplant recipients but also indicates that the infection does not prejudice survival of the transplanted kidney. Even before they receive pharmacologic agents designed to enhance immunologic tolerance of the allograft, candidates maintained on chronic dialysis give evidence of depressed cellular immune responsiveness. The altered immune status has been invoked as an explanation for the propensity of hepatitis B infections to be relatively mild and to evolve into chronic carriage of hepatitis B surface antigen (HBs Ag) in the serum. . . .