tbuckley/cabot-search huggingface dataset:
Abstract 022: Higher Baseline Progenitor Cell Counts in Familial Hypercholesterolemic Patients Compared to Healthy Controls
Authors: Vimal Ramjee, Neal Bhatia, Nima Ghasemzadeh, Ying Guo, Qunna Li, Louette Vaughn, Christine Nell-Dybdahl, Edmund E Waller, Kenneth Brigham, Peter W Wilson, Arshed Quyyumi, Ngoc-Anh Le, Laurence S Sperling
Journal: Circulation Research (2013)

Background: Endothelial injury from exposure to cardiovascular risk factors leads to atherosclerosis, however, an endogenous response to vascular injury characterized by circulating progenitor cells (CPCs) contributes to endothelial repair and regeneration. Although CPCs are known to be inversely related to cardiovascular risk, it is uncertain whether these risk factors are also a stimulus for CPC mobilization. We measured the number of CPCs in patients with familial hypercholesterolemia (FH) and compared them to patients with hyperlipidemia and healthy controls, with the hypothesis that CPC levels would be modulated by FH. Methods: Eight patients with FH on statin therapy (mean age, 48 ± 17 years) were compared with 16 age- and gender-matched hyperlipidemic patients on statin therapy, and 16 healthy volunteers. CPCs were analyzed using flow cytometry (BD FACS Canto II) for mononuclear cell (CD45dim) surface expression of CD34 and a combination of VEGF2R, CD133, and CXCR4 epitopes. Results are expressed as means ± SD or as proportions, and analysis of variance was used to detect differences between the three groups. Results: FH patients had higher circulating numbers of CD34+/CD133+ cells compared to hyperlipidemic (1.49 ± 1.01 vs. 0.88 ± 0.52 cells/µL, p = 0.04, respectively) and healthy counterparts (0.97 ± 0.61 cells/µL, p = 0.08). Similarly, FH subjects also had higher circulating levels of CD34+/CD133+/CXCR4+ cells compared to both the hyperlipidemic (0.68 ± 0.36 vs. 0.30 ± 0.22 cells/µL, p = 0.002, respectively) and healthy group (0.32 ± 0.25 cells/µL, p = 0.003). Conclusions: CPC counts, particularly of early CPCs characterized by CD133, and also those expressing the homing receptor, CXCR4, are higher in FH patients compared to age- and gender-matched healthy controls and patients with hyperlipidemia, independent of statins. This suggests an activation of reparative and regenerative reserve in FH subjects. The increased level of CPCs in FH subjects compared to hyperlipidemic patients may be a collective result of a higher level of lipid burden, lower therapeutic response to anti-hyperlipidemic pharmacotherapy, and chronic immune-activation due to ongoing subclinical endothelial injury in FH patients.
Pharmacogenetic Risk Factors for Altered Bone Mineral Density and Body Composition in Pediatric Acute Lymphoblastic Leukemia.
Authors: Mariël L. te Winkel, Robert D van Beek, Sabine M.P.F. de Muinck Keizer-Schrama, André G. Uitterlinden, Wim C.J. Hop, Rob Pieters, M.M. Van Den Heuvel
Journal: Blood (2009)
A Technique for Intraoperative Bone Scintigraphy
Authors: ANDREW S. KLONECKE, ROBERT LICHO, I. ROSS McDOUGALL
Journal: Clinical Nuclear Medicine (1991)

Since 1981, intraoperative bone scanning has been used at Stanford University Hospital to assist in the localization and excision of skeletal lesions in the surgical suite. The utility of bone scans to detect lesions not otherwise “visible” is valuable in guiding the surgeon to the pathological site. In addition, intraoperative scanning can define the exact amount of tissue to be excised, averting excessive surgery near joints or along weight-bearing bones. Seventeen cases are presented.
Leukemia following treatment of germ cell tumors in men.
Authors: J Pedersen-Bjergaard, M Rørth, N I Nissen, P Philip
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.6.885 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2989447 Leukemia following treatment of germ cell tumors in men. J Pedersen-BjergaardxJ Pedersen-BjergaardSearch for articles by this author , M RørthxM RørthSearch for articles by this author , N I NissenxN I NissenSearch for articles by this author , P PhilipxP PhilipSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.6.885 First Page PDF © 1985 by American Society of Clinical Oncology
Multivariate Analysis of the Impact of Pre-Treatment Serum Ferritin Level On Response and Overall Survival in Patients with Myelodysplastic Syndromes Treated with Azacitidine
Authors: Regina Garcia Delgado, Dunia de Miguel, Alicia Bailen, José Ramón Gonzalez, Joan Bargay, Jose F Falantes, Rafael Andreu, Fernando Ramos, Mar Tormo, Rafael F Duarte, Ma José Jiménez Lorenzo, Salut Brunet, Benet Nomdedeu, Antonio Figueredo, Javier Casaño, Llorenç Badiella, Antonio Fernández Jurado, Guillermo Sanz
Journal: Blood (2012)
Imaging Nigrostriatal Dopaminergic Deficit in Holmes Tremor with 18F-PR04.MZ-PET/CT
Authors: Carlos Juri, Pedro Chana, Vasko Kramer, Rossana Pruzzo, Horacio Amaral, Patrick J. Riss, Frank Rösch
Journal: Clinical Nuclear Medicine (2015)

Holmes tremor is an infrequent clinical syndrome characterized by unilateral rest, postural, and action tremor often secondary to a brain lesion. We herein report an interesting case of Holmes tremor studied with PET and F-PR04.MZ, a new high-affinity radioligand for dopamine transporters, currently under investigation at our center. F-PR04.MZ-PET can be useful to study the integrity of the nigrostriatal dopaminergic system to improve diagnosis and therapeutic outcome in patients with Holmes tremor and Parkinson disease.
A Low-Molecular-Weight Compound K7174 Represses Hepcidin: Possible Therapeutic Strategy Against Anemia Of Chronic Disease
Authors: Tohru Fujiwara, Takashi Ikeda, Yuki Nagasaka, Yoko Okitsu, Noriko Fukuhara, Yasushi Onishi, Kenichi Ishizawa, Ryo Ichinohasama, Naohisa Tomosugi, Hideo Harigae
Journal: Blood (2013)
Distress precipitated by psychiatric training among medical students
Authors: K Kris
Journal: American Journal of Psychiatry (1986)

The author found that, for 35 (22%) of the 159 medical students who sought consultation with her in a medical school mental health service, their training in psychiatry precipitated the consultation. For 18 of these 35 students, acute anxiety or depression was the problem, and 17 were motivated to explore psychotherapy in response to psychiatric courses and clerkships. The author discusses the causes of conflicts engendered by psychiatric teaching: acute symptoms result from a transitory imbalance in the development of the student's identification with both patient and physician. Recognition of this dual identification can heighten psychiatric teachers' sensitivity to the problems that medical students may experience during psychiatric training.
Risk Factors For Cerebral Vasculopathy In a Sickle Cell Disease Newborn Cohort
Authors: Julie Sommet, Corinne Alberti, Laurent Holvoet, Zinedine Haouari, Florence Missud, Ghislaine Ithier, Suzanne Verlhac, Monique Elmaleh, Andre Baruchel, Malika Benkerrou
Journal: Blood (2013)
Reptile-associated salmonellosis in residents in the south east of Ireland 2005 - 2007
Authors: A M O'Byrne, M Mahon
Journal: Eurosurveillance (2008)

Salmonella can be spread through contaminated food, person-to-person transmission, waterborne transmission and numerous environmental and animal exposures. Reptiles (e.g. turtles, lizards, snakes, tortoises, terrapins) serve as reservoirs of Salmonella and can shed Salmonella organisms in faecal material. Over 2,460 serotypes of Salmonella have been identified and many serotypes have been associated with reptiles.
Mosaicism for a <i>SPRED1</i> deletion revealed in a patient with clinically suspected mosaic neurofibromatosis
Authors: R.K. Jobling, I. Lara-Corrales, M.-C. Hsiao, A. Shugar, S. Hedges, L. Messiaen, P. Kannu
Journal: British Journal of Dermatology (2016)

Inactivating SPRED1 mutations cause Legius syndrome, an autosomal dominant RASopathydescribed in 20071. Like Neurofibromatosis Type 1 (NF1), features include cafe-au-lait macules and skin fold freckling. Although neurofibromas, optic gliomas, Lisch nodules, tibial pseudarthrosis and nerve sheath tumors are not seen in Legius syndrome, other symptoms and signs common to the RASopathies such as Noonan-like facial features, pulmonary stenosis, pectus deformity and learning disabilities are reported2,3.

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Prognostic significance of programmed death-ligand 1 (PD-L1) expression on tumor infiltrating immune cells (IC) in patients with stage IIIb colorectal cancer.
Authors: Shigehiro Koganemaru, Naoko Inoshita, Yuji Miura, Yudai Fukui, Yukinori Ozaki, Kenji Tomizawa, Yutaka Hanaoka, Shigeo Toda, Koichi Suyama, Yuko Tanabe, Jin Moriyama, Takeshi Fujii, Shuichiro Matoba, Hiroya Kuroyanagi, Toshimi Takano
Journal: Journal of Clinical Oncology (2016)

611 Background: Programmed death 1 (PD-1)/ PD-L1 pathway is a negative feedback mechanism that suppresses the activity of T cells. Some previous studies showed that positive PD-L1 expression on tumor cells (TC) was poor prognostic factor in patients with colorectal cancer; however, recent studies suggest that IC also play important roles to determine the prognosis in cancer patients. The aim of this study is to investigate the association of clinical and pathological features with PD-L1 expression on TC and IC. Methods: We retrospectively reviewed data of consecutive patients with stage IIIb colorectal cancer (Japanese classification of colorectal carcinoma The 8 th Edition), who underwent surgery and received adjuvant chemotherapy in our institution between January 2009 and July 2012. PD-L1 expression was evaluated by immunohistochemistry (IHC) on TC and IC. Specimens were scored as IHC low (L) or high (H), if &lt; 5% or ≥ 5% of cells were PD-L1 positive, respectively. Results: Seventy-four patients were included in this analysis. Median age was 61 years (range 32-84). Thirty-one (41.9%) and 43 (58.1%) patients received fluoropyrimidine and fluoropyrimidine combined with oxaliplatin as adjuvant chemotherapy, respectively. The median follow-up time was 51.3 months (range 4.6-75.9). The number of patients with PD-L1 expression on TC/IC (H/H, H/L, L/H, and L/L) were 0, 12, 11, and 51, respectively. The median disease-free survival (DFS) in patients with high and low PD-L1 expression on TC were 29.9 months and “not reached”, respectively (hazard ratio [HR] 2.02; 95% confidence interval [CI], 0.85-4.30; P = 0.11). The median DFS in patients with high and low PD-L1 expression on IC were “not reached” and 55.1 months, respectively (HR 0.29; 95%CI, 0.05-0.95; P = 0.04). Conclusions: Although high PD-L1 expression on TC is associated with poor prognosis, high PD-L1 expression on IC positively affects the survival in patients with stage IIIb colorectal cancer.
Effects of Autism Spectrum Disorder Insurance Mandates on the Treated Prevalence of Autism Spectrum Disorder
Authors: David S. Mandell, Colleen L. Barry, Steven C. Marcus, Ming Xie, Kathleen Shea, Katherine Mullan, Andrew J. Epstein
Journal: JAMA Pediatrics (2016)

Most states have passed insurance mandates requiring commercial health plans to cover services for children with autism spectrum disorder (ASD). Insurers have expressed concerns that these mandates will increase the number of children diagnosed with ASD (treated prevalence) and therefore increase costs associated with their care. To our knowledge, no published studies have addressed this question.To examine whether implementing ASD insurance mandates increases the number of commercially insured children diagnosed with ASD.A difference-in-differences study was performed using inpatient and outpatient health insurance claims for children 21 years or younger covered by 3 of the largest insurers in the United States-United HealthCare, Aetna, and Humana-from January 1, 2008, through December 31, 2012, made available through the Health Care Cost Institute. Data analysis was conducted from March 15 to August 11, 2015.Implementation of an ASD insurance mandate in a child's state of residence.The treated prevalence of ASD, measured as a binary indicator of whether a given child in a given calendar month had at least 1 health care service claim associated with a diagnosis of ASD.The adjusted treated prevalence among 1 046 850 eligible children (575 299 male [55.0%]) in states with ASD insurance mandates was 1.8 per 1000 and 1.6 per 1000 among children in states without such a mandate (P = .006). The mean increase in treated prevalence attributable to the mandates was 0.21 per 1000 children during the study period (95% CI, 0.11-0.30; P < .001). Mandates in place longer had a larger effect on treated prevalence. The mean increase in treated prevalence of ASD attributable to the mandate was 0.17 per 1000 children (95% CI, 0.09-0.24; P < .001) in the first year following implementation, 0.27 per 1000 children (95% CI, 0.13-0.42; P < .001) in the second year, and 0.29 per 1000 children (95% CI, 0.15-0.42; P < .001) 3 years or more following implementation.Implementing state ASD insurance mandates resulted in increases in the number of children diagnosed with ASD; these numbers increased each year after implementation. Even 3 years or more after implementation, however, treated prevalence of ASD was much lower than community prevalence estimates. This finding may allay concerns that mandates will substantially increase insurance costs, but it suggests that many commercially insured children with ASD remain undiagnosed or are being treated only through publicly funded systems.
Behavioral evidence for a continuous approach to the perception of emotionally valenced stimuli
Authors: Vanessa LoBue
Journal: Behavioral and Brain Sciences (2015)

Abstract Pessoa's (2013) dual competition model outlines a framework for how cognition and emotion interact at the perceptual levels and provides evidence within the field of neuroscience to support this new perspective. Here, I discuss how behavioral work fares with this new model and how visual detection is influenced by information with affective or motivational content.
P-279 Pembrolizumab for patients with previously treated metastatic adenocarcinoma or squamous cell carcinoma of the esophagus: phase 2 KEYNOTE-180 study
Authors: Shah Manish, Bennouna Jaafar, Shen Lin, Enzinger Peter, Li Qiao, Csiki Ildiko, Koshiji Minori, Doi Toshihiko
Journal: Annals of Oncology (2016)
A Rare Cause of Myoclonus
Authors: Karen M. Doherty, Joanne Shields, Raeburn Forbes, Moyra Gray, Seamus Kearney, Alexander P. Maxwell, John McKinley
Journal: JAMA Neurology (2016)

A woman aged 22 years presented with a 3-year history of jerks when brushing her teeth and a tremor when carrying drinks. Examination revealed a bilateral jerky tremor, stimulus-sensitive myoclonus, and difficulty with tandem gait. Thyroid and liver function test results were normal, but she had rapidly progressive renal failure. Serum copper, ceruloplasmin, and manganese levels were normal, but her urinary copper level was elevated on 2 occasions. Pathological findings on organ biopsy prompted genetic testing to confirm the diagnosis. The differential diagnosis, tissue biopsy findings, and final genetic diagnosis are discussed.
CT Angiography for the Detection of Coronary Artery Stenoses in Patients Referred for Cardiac Valve Surgery
Authors: Maksymilian P. Opolski, Adam D. Staruch, Michal Jakubczyk, James K. Min, Heidi Gransar, Michal Staruch, Adam Witkowski, Cezary Kepka, Won-Keun Kim, Christian W. Hamm, Helge Möllmann, Stephan Achenbach
Journal: JACC. Cardiovascular imaging (2016)
Tropical splenomegaly syndrome.
Authors: M N Lowenthal
Journal: BMJ (1971)

The dental enamel defects may be in the nature of hypo- plasia, hypocalcification, or hypomaturation, and are considered to be due to antenatal, and perhaps unreported, disturbances.The requirements for normal dental develop- ment are not known, but nutrition must play a part, and it can be altered by disease processes.The ectodermal origin of both enamel and the nervous system, with the suggestion that defects in enamel are seen when there is neurological deficit and also a low intelligence lends support to the possibility that the insult occurred early in pregnancy.This is of importance in the elucidation of the aetiology of some neuro- logical and mental defects.It is also a useful pointer for the dental practitioner and paediatrician for a closer examination of the child's intellectual ability and neurological status.
Tissue‐Engineered Fibrin‐Based Heart Valve with Bio‐Inspired Textile Reinforcement
Authors: Ricardo Moreira, Christine Neusser, Magnus Kruse, Shane Mulderrig, Frederic Wolf, Jan Spillner, Thomas Schmitz‐Rode, Stefan Jockenhoevel, Petra Mela
Journal: Advanced Healthcare Materials (2016)

The mechanical properties of tissue‐engineered heart valves still need to be improved to enable their implantation in the systemic circulation. The aim of this study is to develop a tissue‐engineered valve for the aortic position – the BioTexValve – by exploiting a bio‐inspired composite textile scaffold to confer native‐like mechanical strength and anisotropy to the leaflets. This is achieved by multifilament fibers arranged similarly to the collagen bundles in the native aortic leaflet, fixed by a thin electrospun layer directly deposited on the pattern. The textile‐based leaflets are positioned into a 3D mould where the components to form a fibrin gel containing human vascular smooth muscle cells are introduced. Upon fibrin polymerization, a complete valve is obtained. After 21 d of maturation by static and dynamic stimulation in a custom‐made bioreactor, the valve shows excellent functionality under aortic pressure and flow conditions, as demonstrated by hydrodynamic tests performed according to ISO standards in a mock circulation system. The leaflets possess remarkable burst strength (1086 mmHg) while remaining pliable; pronounced extracellular matrix production is revealed by immunohistochemistry and biochemical assay. This study demonstrates the potential of bio‐inspired textile‐reinforcement for the fabrication of functional tissue‐engineered heart valves for the aortic position.
A comprehensive study of the genomic differentiation between temperate Dent and Flint maize
Authors: Sandra Unterseer, Saurabh D. Pophaly, Regina Peis, Peter Westermeier, Manfred Mayer, Michael A. Seidel, Georg Haberer, Klaus F. X. Mayer, Bernardo Ordas, Hubert Pausch, Aurélien Tellier, Eva Bauer, Chris-Carolin Schön
Journal: Genome biology (2016)

Dent and Flint represent two major germplasm pools exploited in maize breeding. Several traits differentiate the two pools, like cold tolerance, early vigor, and flowering time. A comparative investigation of their genomic architecture relevant for quantitative trait expression has not been reported so far. Understanding the genomic differences between germplasm pools may contribute to a better understanding of the complementarity in heterotic patterns exploited in hybrid breeding and of mechanisms involved in adaptation to different environments. We perform whole-genome screens for signatures of selection specific to temperate Dent and Flint maize by comparing high-density genotyping data of 70 American and European Dent and 66 European Flint inbred lines. We find 2.2 % and 1.4 % of the genes are under selective pressure, respectively, and identify candidate genes associated with agronomic traits known to differ between the two pools. Taking flowering time as an example for the differentiation between Dent and Flint, we investigate candidate genes involved in the flowering network by phenotypic analyses in a Dent–Flint introgression library and find that the Flint haplotypes of the candidates promote earlier flowering. Within the flowering network, the majority of Flint candidates are associated with endogenous pathways in contrast to Dent candidate genes, which are mainly involved in response to environmental factors like light and photoperiod. The diversity patterns of the candidates in a unique panel of more than 900 individuals from 38 European landraces indicate a major contribution of landraces from France, Germany, and Spain to the candidate gene diversity of the Flint elite lines. In this study, we report the investigation of pool-specific differences between temperate Dent and Flint on a genome-wide scale. The identified candidate genes represent a promising source for the functional investigation of pool-specific haplotypes in different genetic backgrounds and for the evaluation of their potential for future crop improvement like the adaptation to specific environments.
Case 3-1984
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Sidney S. Braman, Eugene J. Mark
Journal: New England Journal of Medicine (1984)

Presentation of CaseA 58-year-old man was admitted to the hospital because of a pulmonary lesion.He was in a stable state of health until four months earlier, when he experienced the first of several bouts of amaurosis fugax in the left eye accompanied by a mild headache and came to this hospital. The erythrocyte sedimentation rate was 6 mm per hour. A cerebral angiographic examination showed minimal atherosclerosis of the internal carotid artery and a normal ophthalmic artery. A computed tomographic (CT) scan of the brain and a fluorescein angiographic examination were negative. X-ray films of the chest ( . . .
Case 18-1965
Authors: William H. Baker, Benjamin Castleman
Journal: New England Journal of Medicine (1965)

Presentation of CaseAn eighty-six-year-old man was admitted to the hospital because of jaundice.He stated that five months previously "lumps" developed on both sides of the neck. Thereafter, progressive anorexia, belching and a loss of 35 pounds in weight occurred. Five weeks before admission members of his family observed that he was jaundiced; a gastrointestinal series performed at that time was interpreted as normal.Sixteen years before entry the left eye was enucleated because of retinal detachment; microscopical examination disclosed no evidence of tumor. The vision in the right eye deteriorated progressively because of a cataract. Nine years before . . .
Regulation of EBV LMP1-triggered EphA4 downregulation in EBV-associated B lymphoma and its impact on patients’ survival
Authors: Ya-Chi Huang, Sue-Jane Lin, Kai-Min Lin, Ya-Ching Chou, Chung-Wu Lin, Shan-Chi Yu, Chi-Long Chen, Tang-Long Shen, Chi-Kuan Chen, Jean Lu, Mei-Ru Chen, Ching-Hwa Tsai
Journal: Blood (2016)