tbuckley/cabot-search huggingface dataset:
Treatment of Chronic Congestive Heart Failure with Captopril, an Oral Inhibitor of Angiotensin-Converting Enzyme
Authors: Richard Davis, Hillel S. Ribner, Edmund Keung, Edmund H. Sonnenblick, Thierry H. LeJemtel
Journal: New England Journal of Medicine (1979)

The renin-angiotensin system is thought to maintain elevated systemic vascular resistance in heart failure. The hemodynamic effects of captopril (SQ 14225), an oral inhibitor of angiotensin-converting enzyme, were measured in 10 patients with stable congestive heart failure poorly controlled by digitalis and diuretics. At single daily doses of 25 to 150 mg, the cardiac index rose from 1.75 +/- 0.18 to 2.27 +/- 0.39 (mean +/- S.D.) liters per minute per square meter (P less than 0.001), and pulmonary-wedge pressure fell from 26.5 +/- 7.5 to 17.3 +/- 6.1 mm Hg (P less than 0.01). Systemic vascular resistance decreased from 2006 +/- 300 to 1393 +/- 238 dyne seconds per centimeter (P less than 0.001), and mean arterial pressure fell from 83.7 +/- 7.0 to 70.3 +/- 9.9 mm Hg (P less than 0.001) (mean +/- S.D.). Heart rate did not change appreciably. Hemodynamic alterations peaked at 90 minutes and persisted for three to four hours. Control plasma renin activity ranged from 1.1 to 7.3 ng per milliliter per hour and did not correlate with changes in hemodynamic values. Three patients on long-term treatment maintained clinical improvement. Although its mechanism of action has not been completely elucidated, captopril may prove useful in the treatment of chronic congestive heart failure.
Traumatic Arterial Vasospasm
Authors: Philip S. Foisie
Journal: New England Journal of Medicine (1947)

THE opportunity of treating a large number of war wounds of the extremities has demonstrated that vasospasm, of varying intensity and obstinacy, often complicates these injuries. This paper is not primarily concerned with cases of subtotal ischemia in which the immediate viability of the part is threatened but with the less dramatic and much larger group in which the persistence of a relatively low-grade arterial spasm is likely to cause nutritional changes adversely affecting the functional result.Everyone is alarmed when a wound involves or suggests injury to a major artery; modern surgeons are equally apprehensive about the cold, pulseless . . .
NI-67 * THE ROLE OF FLAIR VOLUME AS A PROGNOSTICATING FACTOR IN PATIENTS WITH GLIOBLASTOMA
Authors: W. H. A. Ryu, J. Dronyk, J. J. Kelly
Journal: Neuro-Oncology (2014)

BACKGROUND: Volumetric analysis on T1-weighted post-gadolinium (T1-PG) magnetic resonance imaging (MRI) sequence is central in managing patients with glioblastoma. It is unclear how the contrast enhancing tumor volume relates to abnormal findings in other MRI sequences such as fluid attenuated inversion recovery (FLAIR) and whether additional prognosticating information can be derived from these supplementary radiographic techniques. OBJECTIVES: To determine the relationship between volumetric measurements (T1-PG, FLAIR) and survival in patients with newly diagnosed GBM using rapid volumetric measurement (MacDonald ellipsoid method) for estimation of tumor volume. We will also compare the accuracy of rapid volumetric measurement to a manual tracing method for determination of tumor volume. METHODS: Tumor volumes of 30 patients (10 females, mean age 63 years) with diagnosis of glioblastoma were retrospectively measured using pre-operative MRI. Enhancing tumor volume on the T1-PG sequence was calculated using both a manual tracing method and the MacDonald ellipsoid method while volume of abnormal signal intensity on the FLAIR sequence was measured using the MacDonald ellipsoid method. The relationship between volumetric analyses and duration of survival were examined. RESULTS: Mean volume of enhancing tumors in the T1-PG sequence was 43.93 cm3 and 48.30 cm3 (manual and MacDonald ellipsoid method respectively), while mean volume of abnormal signal intensity in the FLAIR sequence was 147.60 cm3. There was moderate correlation between the T1-PG and FLAIR volumes (r= 0.65). Average duration of survival from surgery was 341 days. Neither tumor volume measurements correlated with duration of survival. CONCLUSIONS: Rapid measurement of tumor volume is a reasonable and accurate estimate of manually traced tumor volumes. Both T1-PG and FLAIR alone do not correlate with survival in this small group of patients.
GENDER DIFFERENCES IN CORONARY REVASCULARIZATION RATES IN THE UNITED STATES: INSIGHT FROM NATIONAL INPATIENT SAMPLE
Authors: Estefania Oliveros, Vladimir Lakhter, Chad Zack, Yevgeniy Brailovsky, Harish Jarrett, Michael Lashner, Vikas Aggarwal, Brian O’Murchu, Brian O’Neill, Howard Cohen, Alfred Bove, Riyaz Bashir
Journal: Journal of the American College of Cardiology (2015)
Abstract 4375: Cancer protection by pregnancy – a link with microchimeric fetal/maternal stem cells in a stromal niche: Breast cancers are hypochimeric, but the HER2-subtype is hyperchimeric
Authors: Eugen Dhimolea, Viktoria Denes, Sonya Aziz-Zaman, Peter Geck
Journal: Cancer Research (2011)

Abstract The PURPOSE of our studies was to investigate the origin and cancer relations of embryonic/fetal stem cells in breast cancer. HYPOTHESIS. During pregnancy the documented exchange of fetal and maternal stem/progenitors establish long-term integration in the recipient organism. We propose that the breast is a potential niche and this new stem cell pool may affect breast cancer. OBJECTIVES. (i) To work out more sensitive methods to detect Y- and X-chromosomal markers from embedded, formaldehyde-fixed tissue samples; (ii) To find the tissue compartment for the long-term microchimerism niche in the breast; and (iii) to collect quantitative chimerism data to investigate non-chimeric, hypochimeric, microchimeric and hyperchimeric contribution to cancer. EXPERIMENTS. We developed new systems for Y-signal detection (single-amplicon/multiple-target analysis) and X-haplotype analysis with significantly increased sensitivity from low-integrity samples. We analyzed 55 normal samples representing stromal, ductal and lobular tissues and 102 invasive ductal breast cancer samples. Quantitative amplifications were performed following recent MIQE recommendations. We used fluorescent in-situ hybridizations (FISH) to confirm microchimerism. The data were analyzed by extensive statistical analyses and only data with statistical significance are presented. RESULTS. We found 19.6% microchimerism in cancer samples, in contrast to 40% in normal tissues. The results confirm that hypochimerism promotes but microchimerism protects from cancer. We show for the first time that the long-term niche for post-pregnancy microchimeric (male) cells is the mammary stroma but they don't integrate into the ducts, the site of most cancers. Based on the findings we propose that breast cancer protection by pregnancy may be a stromal function and involves fetal microchimerism. Unexpectedly, we also found that a cohort of breast cancers show runaway microchimerism with significantly increased male-cell content. This is the first report that hyperchimerism correlates with the HER2-subtype and unfavorable prognosis. CONCLUSIONS. We developed a new assay and our studies demonstrate previously unrecognized significant stromal integration of fetal/maternal stem cells in protection from breast cancer. We also found, however, that excessive microchimerism promotes cancer and correlates with the HER2-subtype. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4375. doi:10.1158/1538-7445.AM2011-4375
A Familial Syndrome of Pancreatic Cancer and Melanoma with a Mutation in the<i>CDKN2</i>Tumor-Suppressor Gene
Authors: Alison J. Whelan, Detlef Bartsch, Paul J. Goodfellow
Journal: New England Journal of Medicine (1995)

The distinguishing characteristics of familial cancer syndromes are an inherited predisposition to one or more characteristic types of tumors, early age at onset, and multiple synchronous or asynch...
Speedier Drug Approval Modeled After FDA's Cancer Drug Review System
Authors: C. vanchieri
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Speedier Drug Approval Modeled After FDA's Cancer Drug Review System Get access Cori vanchieri Cori vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 9, 6 May 1992, Pages 666–669, https://doi.org/10.1093/jnci/84.9.666 Published: 06 May 1992
Cutaneous Larva Migrans
Authors: J M Blaum, E F Omura
Journal: New England Journal of Medicine (1998)

Figure 1. A hookworm larva was acquired by a 47-year-old man during a vacation at a beach on the Alabama coast of the Gulf of Mexico. An isolated lesion resulted, and it resolved after liquid-nitrogen cryotherapy was administered just beyond the advancing end (single arrow). This photograph was taken a week and a half after the larva was acquired. The double arrows indicate the point where the larva's journey began, with the initial area of inflammation already resolving.
Incidental Finding of Varicocele Detected on a Blood-Pool Image on Tc-99m HMDP Bone Scintigraphy
Authors: M Minoves, P Bassa, A Clemente, A Rivas, E Riera, J Setoain, J M Costansa
Journal: Clinical Nuclear Medicine (2000)

Bone scintigraphy was performed in a 16-year-old male football player who had a 2-month history of left inguinal pain to identify possible osteitis pubis. The blood-pool image on bone scintigraphy revealed a focal area of increased activity in the left hemiscrotal region, extending proximally to the area of the left iliac vessels. Testicular ultrasonography confirmed the presence of a left testicular varicocele.
AB0376 Gait assessment in patients with rheumatoid arthritis using the modular electronic baropodometer:
Authors: E. Moreira, A. Jones, H.A.V. Oliveira, F. Jennings, J. Natour
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is an auto-immune disease of unknown etiology, that can result in disability and a reduction in functionality. Gait alterations are common in patients with RA and it is associated with foot pain and deformity. <h3>Objectives</h3> Assess gait variables in patients with RA and foot pain using the modular electronic baropodometer. <h3>Methods</h3> Eighty female with RA between 18 and 65 years with a diagnosis of RA and foot pain ranging from 4 to 8 points on visual analogue scale (VAS) scale were analyzed. Patients with other musculoskeletal conditions in symptomatic lower limbs, conditions of the central or peripheral nervous systems, diabetes mellitus and an inability to walk were excluded. Evaluations were performed using a VAS for pain, the Health Assessment Questionnaire (HAQ), foot function index and six-minute walk test. Gait analysis was performed using AM Cube - FootWork Walk analysis system. The correlations between pain/function and baropodometer parameters were analysed. <h3>Results</h3> Patients had a mean disease duration of 12.38 (7.82) years, diagnosis time of 11.09 (7.69) years and body mass index of 26.24 (4.82). These Patients 86.25% were functional class 1 and 13.75% functional class II, 65% were current use of disease modifying antirheumatic drug (DMARD) and biologics 35%.The data regarding clinical and baropodometer parameters were presented in table 1. <h3>Conclusions</h3> Function was correlated with almost all parameters of baropodometer, the bodily oscillation was the only parameter that did not show correlation with function. Pain was correlated with the parameters related to center of force and bodily oscillation in the sagittal plane. <h3>References</h3> Van der Leeden M, Steultjens MP, Terwee CB, Rosenbaum D, Turner D, Woodburn J, Dekker J. A systematic reviw of instruments measuring foot function, foot pain, and foot-related disability in patients with rheumatoid. Arthritis Rheum 2008;59(9):1257-69. Simkin A. The dynamic vertical force distribution during level walking under normal and rheumatic feet. Rheumatol Rehabil 1981;20:88–97. <h3>Disclosure of Interest</h3> None Declared
PREDICTORS OF 1 YEAR NET ADVERSE CARDIOVASCULAR EVENTS (NACE) AMONG ACS PATIENTS UNDERGOING PCI WITH CLOPIDOGREL OR PRASUGREL: ANALYSIS FROM THE PROMETHEUS REGISTRY
Authors: Siddharth A. Wayangankar, Usman Baber, Kanhaiya Poddar, Sandra Weiss, Timothy Henry, J. Muhlestein, Brian Baker, Roxana Mehran, Annapoorna Kini, Samantha Sartori, Sunil Rao, William Weintraub, Craig Strauss, Anthony DeFranco, Catalin Toma, Stuart Keller, Mark Effron, Samir Kapadia
Journal: Journal of the American College of Cardiology (2016)
AB1291 Intraarticular power doppler signal at MCP joint and its assessment in early rheumatoid arthritis
Authors: P. Mandl, E. Filippucci, S. Benis, G. Baksa, L. Patonay, P.V. Balint, W. Grassi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The detection of intraarticular Power Doppler (PD) signal in metacarpophalangeal (MCP) joints may play a key role in the assessment of patients with early arthritis. Currently used quantification methods for PD however do not provide information related to the intraarticular topographic distribution of the signal. The evaluation of PD signal in the MCP joint is further hindered by the fact that new, highly sensitive PD systems allow the detection of normal PD signal in the MCP joints of healthy subjects, likely corresponding to physiological feeding vessels. <h3>Objectives</h3> Our aim within this pilot investigation was to identify different patterns of intraarticular PD signal in the MCP joint based on its topographic location and to demonstrate the presence of physiological feeding vessels in cadaver preparations obtained with corrosion and also in histological sections. <h3>Methods</h3> We evaluated a panel of one hundred images obtained at MCP joint level in both healthy subjects and patients with early arthritis using dorsal longitudinal and transverse views. The presence of physiological vessels in the metacarpal head was evaluated in cadaver specimens subjected to corrosion, while those in the dorsal fat pad were demonstrated in histological sections obtained from cadavers of patients, with negative case histories for diseases involving the small joints of the hand. <h3>Results</h3> We identified at least two distinct patterns of intraarticular PD signal: pattern 1 (extrasynovial) was characterized by intraarticular, but not intrasynovial PD signal while pattern 2 (intrasynovial) was characterized by intraarticular and intrasynovial PD signal in structures possessing a synovial lining. Both patterns could be demonstrated in healthy individuals and also in patients with early arthritis. We also confirmed the presence of physiological vessels in the metacarpal head as well as in the dorsal fat pad of cadavers. <h3>Conclusions</h3> Extrasynovial PD signal may be due to the vasodilation of pre-existing feeding vessels in intraarticular areas that do not possess a synovial lining, e.g. the dorsal fat pad as often seen in patients with early arthritis. Intrasynovial PD signal may correspond to the presence of physiological feeding vessels at the metacarpal head seen in healthy individuals, similar signals however may also be detected in patients with erosive disease. The evaluation of intraarticular PD signal in the MCP joint therefore remains problematic, especially in cases where grey-scale changes characteristic to synovitis are lacking. <h3>Disclosure of Interest</h3> None Declared
A5.16 Characterisation of an arthritis rat model with a periodontal disease induced by<i>Porphyromonas Gingivalis</i>
Authors: M Rinaudo-Gaujous, G Courbon, V Blasco-Baque, S Paul, H Marotte
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Epidemiological studies have demonstrated the association between rheumatoid arthritis (RA) and periodontal disease (PD) susceptibility and severity. The missing link between RA and PD association could be <i>Porphyromonas gingivalis</i> ( <i>PG</i>) involved in PD pathogenesis. Role of <i>PG</i> is growing fast since it is the only bacteria able to citrullinate peptides and could induce autoimmune response through development of anti-citrullinated protein antibodies (ACPA). We have already demonstrated that anti- <i>PG</i> antibodies were correlated with ACPA in RA patients. The aim of this study is to develop a physiopathological rat model of PD induced by <i>PG</i> infection to follow the occurrence of early signs of RA and to score bone loss. <h3>Materials and methods</h3> Female rats Lewis were randomly divided into two groups: oral infection with <i>PG</i> or negative control. The oral infection was performed by oral gavage with <i>PG</i> during 1 month. Clinical parameters including articular index were monitored during the experiment. Blood samples were collected at different time point for determination of ACPA, RF, MMP-3 (biomarker for RA and PD destruction) and anti- <i>PG</i> antibodies by ELISA assay. Count of activated T lymphocytes that secrete IL-17 was performed by ELISPOT. Bone microarchitecture, bone mineral density (BMD) profiles were obtained by µ-computed tomography (µ-CT) and dual energy x-rays absorptiometry (DXA) x-rays, respectively. <h3>Results</h3> ELISA assay for ACPA determination in rats is set up and correlation between arthritis and ACPA has been established (p &lt; 0.01). Moreover, ACPA is found in early phase of arthritis compared to controls (p &lt; 0.01). Development of RF, MMP-3 assay, ELISPOT and radiological evaluation are still ongoing. <h3>Conclusions</h3> The development of a reliable animal model of arthritis induced by periodontal disease with <i>PG </i>is essential for the test of new therapeutics in the future.
NSABP B-38: Definitive analysis of a randomized adjuvant trial comparing dose-dense (DD) AC followed by paclitaxel (P) plus gemcitabine (G) with DD AC followed by P and with docetaxel, doxorubicin, and cyclophosphamide (TAC) in women with operable, node-positive breast cancer.
Authors: Sandra M. Swain, Gong Tang, Charles E. Geyer, Priya Rastogi, James Norman Atkins, Paul P. Donnellan, Louis Fehrenbacher, Catherine A. Azar, Andre Robidoux, Jonathan Polikoff, Adam Brufsky, David D. Biggs, Edward A. Levine, John L. Zapas, Louise Provencher, Edith A. Perez, Soonmyung Paik, Joseph P. Costantino, Eleftherios P. Mamounas, Norman Wolmark
Journal: Journal of Clinical Oncology (2012)

LBA1000 The full, final text of this abstract will be available at abstract.asco.org at 12:01 AM (EDT) on Monday, June 4, 2012, and in the Annual Meeting Proceedings online supplement to the June 20, 2012, issue of Journal of Clinical Oncology. Onsite at the Meeting, this abstract will be printed in the Monday edition of ASCO Daily News.
Case 18-2000
Authors: Thomas F. Delaney, G Petur Nielsen
Journal: New England Journal of Medicine (2000)

Presentation of CaseA 45-year-old woman was admitted to the hospital because of a mass at the apex of her right lung.The patient had been well until three and a half years earlier, when she began to have paresthesias in the fourth and fifth fingers of her right hand. Six months later, she began to have intermittent pain in her right shoulder and arm. Nine months before admission, she noted anhidrosis on the right side of her face. Two months later, the pain in her shoulder and arm became progressively more severe and required repeated doses of analgesic agents. . . .
Abstract 1181: P73 regulates the expression of KAI1, metastasis suppressor gene
Authors: Ji Hee Lee, Woo Kyun Bae, Jun eul Hwang, Sang Hee Cho, Ik Joo Chung
Journal: Cancer Research (2012)

Abstract KAI1, a metastasis suppressor gene of various cancers, has been known to inhibit tumor metastasis without affecting primary tumor growth. Identification of transcription factor regulating KAI1 is important for understanding tumor metastasis mechanism. P73 binding site within the KAI1 promoter were characterized by luciferase assay using reporter plasmids containing serial deletion promoter regions of KAI1 gene and chromatin-IP assay. To confirm whether the over-expressed KAI1 gene regulated by p73 in the transcriptional level was active, cell motility was analysed by using an adhesion and invasion assay. Here, we first identified that KAI1 is transcriptionally regulated by p73, a p53 family member, in various cancer cell lines. In p53-deficient cell lines, p73 had highest promoter binding activity in the KAI1 promoter regions between −903 and −846 bp, known as a p53-binding site. Human colon cancer cells stably overexpressing p73 showed that in vitro extracellular matrix adhesion and invasive potential was decreased compared with parental cells. These data explain that p73 regulate the KAI1 gene expression in the transcription level by binding on the specific region of the KAI1 promoter. In addition, it could be suggested that decreased invasion suppressive effect of KAI1 in invasive tumor and tumor cell lines caused by weak expression of KAI1 could be restored by increasing the p73 level. P73 might contribute the metastasis suppressive effect through upregulating KAI1 gene expression in invasive tumor and tumor cell lines. Taken together, our present results suggest that p73 contributes to KAI1 promoter activity in cells and plays an important role in the repression of tumor metastasis function via regulation of KAI1 expression in invasive tumor and tumor cell lines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1181. doi:1538-7445.AM2012-1181