tbuckley/cabot-search huggingface dataset:
Possible pandemic threat from new reassortment of influenza A(H7N9) virus in China
Authors: Z Meng, R Han, Y Hu, Z Yuan, S Jiang, X Zhang, J Xu
Journal: Eurosurveillance (2014)

Avian influenza A(H7N9) virus re-emerged in China in December 2013, after a decrease in the number of new cases during the preceding six months. Reassortment between influenza A(H7N9) and local H9N2 strains has spread from China's south-east coast to other regions. Three new reassortments of A(H7N9) virus were identified by phylogenetic analysis: between A(H7N9) and Zhejiang-derived strains, Guangdong/Hong Kong-derived strains or Hunan-derived A(H9N2) strains. Our findings suggest there is a possible risk that a pandemic could develop.
Thrombotest versus One-Stage Prothrombin-Time Determination
Authors: Charles B. Moore, Myrton F. Beeler
Journal: New England Journal of Medicine (1961)

PROLONGED anticoagulant therapy of thromboembolic disease with coumarin and related drugs has become increasingly common in recent years and has heightened awareness of the shortcomings of the Quick one-stage prothrombin-time method for controlling dosage of the drug. Development of the one-stage prothrombin-time procedure made long-term anticoagulation possible. However, it has been the experience here and elsewhere1 that a major or minor bleeding episode may develop in many patients on long-term therapy, occasionally while the prothrombin time is in the therapeutic range. This range for the one-stage method is generally taken to be a patient's value one and a half to . . .
Transgastric endoscopic ultrasound with fine-needle aspiration and ERCP using percutaneous-assisted transprosthetic endoscopic therapy in a gastric bypass patient
Authors: Ryan Law, Todd Baron, Mark Topazian
Journal: Endoscopy (2015)

Percutaneous-assisted transprosthetic endoscopic therapy (PATENT) is a novel endoscopic technique recently developed which uses a nonnatural orifice to gain access to the gastrointestinal tract for performance of interventional procedures during a single session [1]. PATENT permits endoscopic retrograde cholangiopancreatography (ERCP) in patients with long-limb Roux-en-Y gastric bypass (RYGB) and overcomes limitations of other access-gaining techniques [2] [3]. We present the first case of endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) using PATENT.
AB0496 Segmental evaluation of joint limitations in scleroderma - prospective monocentric study
Authors: E. Ricard, C Verdier-Kessler, A Sparsa, P Vergne-Salle, V Doeffoel-Hanzt, C. Bonnet, C. Dufauret-Lombard, P. Bertin, AL Fauchais
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> A multidimensional assessment is essential to establish the rehabilitation program in patients with scleroderma in order to limit functional disability. In fact, scleroderma is responsible for unfunctionality of the hand in 38% of the limited forms and 64% of the diffuse forms, linked to cutaneous and periarticular fibrosis, Raynaud's phenomenon and digital ulcers. <h3>Objectives</h3> <h3>Methods</h3> We prospectively studied the joints limitation of the hand and other joints in 39 patients with scleroderma at a multidisciplinary consultation. Rodnan score, Health Assessment Questionnaire score (HAQ) and hand functional indice of Cochin were systematically performed. <h3>Results</h3> Among the 39 patients, 29 had a limited form. The average age was 58.2 ± 13.9 years and mean disease duration was 6.6 ± 6.1 years. Rodnan score averaged 8.2 ± 8.2, HAQ 1.12 ± 0.818 and the hand scale of the Cochin 24 ± 22. 23 patients (59%) complained of joint pain (mean EVA score 3.6, range 0.5 to 8). We observed a limitation of joints' hand in 69% of patients (n = 27) with an average number of limited joints of 1.5 ± 3.4 for the metacarpophalangeal (MCP), 3.8 ± 4.5 for proximal interphalangeal joints (PIP) and 3.1 ± 3.8 for the distal interphalangeal joints (DIP). The pulp-palm distance is higher than zero in 44% of cases. Limitations of joints of the hand affect autonomy (hand Cochin and HAQ, p &lt;0.05) and appeared independent of age, duration of Raynaud development and scleroderma or the existence of previous digital ulcerations. Patients with diffuse scleroderma are characterized by increased difficulties in closing the hand (number of fingers with a distance pulpo-palmar non zero 4.3 ± 3.2 vs 0.9 ± 1.8, p = 0.002), reduced range of motion of the MCP (4.2 ± 5 vs. 0.5 ± 1.9, p = 0.002) and limitations of other limb joints (7 ± 3.2 vs. 2.03 ± 2.9, p = 0.0001). Difficulties in closing the hand, limitation of MCP and PIP joints are correlated with the Rodnan score (respectively, p &lt;0.001, p = 0.0159, p = 0.0098). Only limitations DIP joints didn't correlate with Rodnan score. Patients receiving human help at home are also characterized by increased difficulties in closing the hand, a limited number of MCP joints of the dominant hand significantly higher (p &lt;0.05). <h3>Conclusions</h3> Joints limitations of the hand in scleroderma are extremely frequent source of disability and appear to be correlated with cutaneous sclerosis. A early and targeted physiotherapy should be implemented to reduce this handicap. <h3>Disclosure of Interest</h3> None Declared
Abstract P2-05-14: Clinical significance of Lysil oxidase-like 2 (LOXL 2) in breast cancer
Authors: SG Ahn, HM Lee, SH Hwang, SA Lee, J Jeong, H-E Lee
Journal: Cancer Research (2012)

Abstract Introduction: Several preclinical studies provided relevant evidences that lysine oxidase-like 2 (LOXL2) is associated with invasiveness and metastasis in breast cancer. To investigate the clinical significance of LOXL2, we performed survival analysis with LOXL-2 in breast cancer patients. Method: A cohort treated at Gangnam Severance hospital, Seoul, Korea between January 1996 and December 2004 was studied. The immunohistochemical analyses with LOXL-2 antibody were performed in the 309 patients. The patients was stratified into two groups based on the expression level of LOXL-2. Kaplan-Meier and Cox's methods were used to define prognostic factors associated with breast cancer survival. Results: LOXL-2 positive group was 50 patients (16.2%) and 259 patients (83.8%) are LOXL-2 negative group. The proportion of estrogen receptor-negative patients was significantly higher in LOXL-2 positive group (54.0 vs. 37.0 %, P = 0.040). The Kaplan-Meier overall survival estimate at 5 year for the breast cancer patients with negative LOXL-2 was higher than that for the patients with positive LOXL-2 (88.0 vs. 71.8 %, P = 0.008). In the multivariate analysis for overall survival, lymph node metastasis (Hazard Ratio (HR) 0.32, 95% confidence interval (CI) 0.17–0.61) and positive LOXL-2 (HR 0.53, 95% CI 0.29–0.97) were significantly associated. In the multivariate analysis for distant metastasis-free survival, age younger than 35 years (HR 0.52, 95% CI 0.30–0.91), lymph node metastasis (HR 0.29, 95% CI 0.16–0.54), high histologic grade (HR 0.54, 95% CI 0.32–0.89) and positive LOXL-2 (HR 0.55, 95% CI 0.31–0.97) were demonstrated as significant prognostic factors. Conclusion: In breast cancer patients, overexpression of LOXL-2 is a poor prognostic factor for overall survival and distant metastasis-free survival. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-05-14.
974 IMMUNOLOGICAL DISEASES AS A RISK FACTOR FOR SURVIVAL IN PRIMARY SCLEROSING CHOLANGITIS: INSIGHT INTO PATHOGENESIS?
Authors: C. Rupp, A. Mummelthei, P. Sauer, K.-H. Weiss, P. Schirmacher, A. Stiehl, W. Stremmel, D.N. Gotthardt
Journal: Journal of Hepatology (2012)
ABERRANT SODIUM INFLUX IS SUFFICIENT TO CAUSE CARDIOMYOPATHY AND SPONTANEOUS SUSTAINED ATRIAL FIBRILLATION IN MICE
Authors: Elaine Y. Wan, Jeffrey Abrams, Richard Weinberg, Alex Katchman, Sergey Zakharov, Lin Yang, Joseph Bayne, John Morrow, Hasan Garan, Steven Marx
Journal: Journal of the American College of Cardiology (2016)
The Race Study: Comparison of Carrying Time, Confidence in Epinephrine Auto-Injector (EAI) Use, and Experience with EAI Training Among Patients with Auvi-Q Versus Epipen
Authors: Jay M. Portnoy, Wenhui Wei, Augustina Ogbonnaya, Dionne M. Hines, Rolin L. Wade, William Daley
Journal: Journal of Allergy and Clinical Immunology (2015)
Varmus Strikes "Reasonable Pricing" Clause in CRADAs
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Varmus Strikes “Reasonable Pricing” Clause in CRADAs Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 9, 3 May 1995, Pages 642–643, https://doi.org/10.1093/jnci/87.9.642-a Published: 03 May 1995
Abstract 4327: A novel protease resistant antibody platform with selectable cell killing functions.
Authors: Michelle Kinder, Katharine Grugan, Keri Soring, William Strohl, Robert Jordan, Randall Brezski
Journal: Cancer Research (2013)

Abstract Invasive cancers express matrix metalloproteases, such as MMP-3 and MMP-7, which have the ability to cleave human antibodies in the lower hinge region. The human IgG lower hinge region contains two heavy chains, and cleavage occurs in a two-step process. First, one heavy chain is cleaved, resulting in a singly-cleaved intermediate. Cleavage of the second heavy chain liberates the Fc region from the antigen-binding region, resulting in an Fc fragment and a F(ab’)2 fragment. Previous work has demonstrated that the singly-cleaved intermediate accumulates on the surface of IgG1-opsonzied tumor cells in the presence of MMPs. The singly-cleaved intermediate is indistinguishable from the intact IgG counterpart when assessed by analytical techniques under native conditions and maintains normal antigen binding. However, the singly-cleaved intermediate displays a profound loss of Fc-mediated cell-killing functions both in vitro (e.g. ADCC and CDC) and with in vivo cell clearance, presumably because the lower hinge contains key recognition points for both FcγRs and the C1q component of complement. Singly-cleaved IgGs are of particular concern with regards to human IgG1 monoclonal therapeutic antibodies, because the proposed mechanisms of action for several anti-tumor mAbs in the clinic may be partially dependent on Fc effector functions, such as ADCC and CDC. For this reason, our group and others have proposed that cleavage and the subsequent inactivation of Fc-effector functions of human IgG antibodies may function as an immune evasion mechanism. To overcome the loss-of-function associated with human IgG1 cleavage, we aimed to develop a protease-resistant IgG1 platform which would still maintain Fc-mediated cell-killing functions. Mutation of the lower hinge of IgG1 provided protease-resistance, but also resulted in a loss of Fc-effector functions. Through specific mutations of amino acids in the CH2 region to enhance complement or Fcγ receptor binding, we were able restore or even enhance cell-killing functions selectively while maintaining protease-resistance. Therefore, we were able to generate protease-resistant antibodies with the ability to mediate either complement-dependent and/or antibody-dependent cellular cytotoxicity, which were also significantly resistant to inactivation by proteases associated with many invasive cancers. Citation Format: Michelle Kinder, Katharine Grugan, Keri Soring, William Strohl, Robert Jordan, Randall Brezski. A novel protease resistant antibody platform with selectable cell killing functions. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4327. doi:10.1158/1538-7445.AM2013-4327
UPPER LIMIT OF EXPANSION RATES OF THORACIC AORTIC DIAMETER IN ASYMPTOMATIC POPULATION EVALUATED BY A ROUTINE HEART CT SCAN
Authors: Song Shou Mao, Dong Li, Yanting Luo, Yanlin Gao, Younus Syed, Ferdinand Flores, Shannon Chen, Brian Rubin, Matthew Budoff
Journal: Journal of the American College of Cardiology (2015)
Physiological variables as markers for symptoms, risk, and interventions in heart failure
Authors: Jay N Cohn
Journal: Circulation (1993)

Heart failure is characterized by hemodynamic abnormalities, impaired exercise capacity, and shortened life expectancy. The risk of death is influenced by a number of physiological abnormalities, the severities of which are not closely correlated. Impaired lett ventricular function can be improved by vasodilator or inotropic therapy, but improvement in exercise capacity is more difficult to document. A reduction in long-term mortality has been demonstrated in response to therapy with the vasodilator combination of hydralazine and isosorbide dinitrate as well as with the converting enzyme inhibitors. The mechanism by which survival is improved is not known but appears to include a sustained increase in lett ventricular ejection fraction
Abstract MS2-2: Nipple-Sparing Mastectomy with Nipple Areola Intra-Operative Radiotherapy: One Thousand and One Cases of a Five Years Experience at the European Institute of Oncology of Milan (EIO)
Authors: J-Y Petit
Journal: Cancer Research (2010)

Abstract Background: in order to reduce mutilation, nipple-areola complex (NAC) conservation can be proposed for a treatment of breast cancer when mastectomy is indicated. To reduce the risk of retro areolar recurrence, a novel radiosurgical treatment combining subcutaneous mastectomy with intraoperative radiotherapy (ELIOT) is proposed. Methods: In a series of more than 1900 Nipple Sparing Mastectomies (NSM) performed at the European Institute of Oncology (IEO-Milan), 1007 (in which 37 bilateral), were registered from March 2002 to November 2007, for invasive carcinoma in 82% of the patients and in situ carcinoma in 18%. Clinical complications, aesthetic results, oncological and psychological results were recorded. A comparison was performed between the 843 patients who received ELIOT and the 208 who underwent delayed one-shot radiotherapy on the days following the operation. Results: The median follow up time was 52 months (range 1.16-100.73) for a minimum follow up of a 6 months for 100% of the patients. The NAC necrosed totally in 40 cases (3,9%) and partially in 66 (6.5%) and was removed in 60 (5.5%). Twenty four infections (2.56%) were observed and 51 (4.85%) prostheses removed. The median rate of the patients for global cosmetic result on a scale ranging from 0 (worst) to 10 (excellent) was 8. Evaluation by the surgeon in charge of the follow-up gave a similar result. Only 11% of the patients reported a partial sensitivity of the NAC. Of the 31 local recurrences (3%) 21 occurred close to the tumour site or in other quadrant, 7 close to the NAC corresponding to the radiation field and 3 Paget. Overall, 82 cases of metastases (8.1%) and 28 deaths (2.7%) were observed. No significant outcome difference was observed between the 843 patients receiving intraoperative radiotherapy (ELIOT) and 208 patients receiving delayed irradiation. LR rate of a series of 597 NSM with invasive carcinomas was 25 (4.18%) after a follow up of 59 months Our psychological analysis concluded that sixty eight per cent of patients were satisfied with their reconstructed breast and 97% were satisfied with the preservation of the NAC. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr MS2-2.
THE IMPACT OF THE PRESENCE AND EXTENT OF VALVE CALCIFICATION ON LONG–TERM RESULTS OF PERCUTANEOUS MITRAL COMMISSUROTOMY
Authors: Claire Bouleti, Bernard Iung, Eric Brochet, David Messika–Zeitoun, Dominique Himbert, Eric Garbarz, Delphine Detaint, Bertrand Cormier, Alec Vahanian
Journal: Journal of the American College of Cardiology (2013)
O163 TURQUOISE-II: SVR12 RATES OF 92–96% IN 380 HEPATITIS C VIRUS GENOTYPE 1-INFECTED ADULTS WITH COMPENSATED CIRRHOSIS TREATED WITH ABT-450/R/ABT-267 AND ABT-333 PLUS RIBAVIRIN (3D+RBV)
Authors: F. Poordad, C. Hezode, R. Trinh, K.V. Kowdley, S. Zeuzem, K. Agarwal, M.L. Shiffman, H. Wedemeyer, T. Berg, E.M. Yoshida, X. Forns, S.S. Lovell, B. Da Silva-Tillmann, A.L. Campbell, T. Podsadecki
Journal: Journal of Hepatology (2014)
EXPRESSION OF THE RECEPTOR FOR ADVANCED GLYCATION END-PRODUCTS (RAGE) IN HUMAN LEFT ATRIAL TISSUE AND ATRIAL FIBROSIS
Authors: Pil-Sung Yang, Junbeom Park, Tae-Hoon Kim, Jae-Sun Uhm, Kim Jong-Youn, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Journal: Journal of the American College of Cardiology (2016)
P106 Sputum Induction Reduces The Need For Bronchoscopy In School-aged Children With Cystic Fibrosis
Authors: N. Collins, K. Robson, P. Nagakumar, S. Saglani, N. Voase, J. Davies
Journal: Thorax (2014)

<h3>Background</h3> Early detection of organisms such as <i>Pseudomonas aeruginosa</i> in CF is essential for successful eradication but is difficult in children, relying largely on non-invasive methods such as cough swabs (C/S) with sub-optimal sensitivity and specificity. Bronchoalvelolar lavage (BAL) remains the gold standard but disadvantages are its invasive nature, high cost and inability to be performed frequently. Sputum induction (SI) has previously been reported as a useful and safe technique in young children with CF, but it is not yet widely used. Hypothesis As part of a quality improvement initiative, we hypothesised that SI would reduce the need for BAL in school-aged CF children with deteriorating lung function and no significant bacterial growth on CS. <h3>Methods</h3> After CS and bronchodilator, 7% hypertonic saline was nebulised via an ultrasonic Ultraneb (DeVilbiss Healthcare) for 15 min. Spirometry was performed pre, post and at 5 min intervals throughout. Sputum was collected at 5 min intervals, and at the end of the procedure physiotherapy was performed to collect more sputum. If a child was unable to expectorate then a CS or oropharyngeal (OP) suction was performed. <h3>Results</h3> 39 children (41% male), median age 11 years (range 5–16 years), median FEV<sub>1 </sub>85% (range 39–112%) performed SI from June 2102 to July 2014. Significant bronchoconstriction occurred in 11%. 2 adverse events occurred (vomiting and dizziness). The procedure took a mean of 90 min including equipment set up and cleaning. 34/39 (87%) expectorated a sputum sample of which 15 (38.5%) had a positive bacterial culture; only 3 of these patients (20%) grew the same organism on the preceding CS. Five patients avoided planned BAL due to a positive SI result and 2 avoided an admission for intravenous antibiotics. <h3>Conclusion</h3> SI is well tolerated in the majority of school-aged children with CF. It has a higher rate of positive bacterial culture than same-day CS and, in this cohort, avoided the need for bronchoscopy in a significant proportion. It is a time-consuming procedure, but based on these data, we consider that establishing SI as a clinical procedure will be a priority for our service.
Case 28-1996
Authors: Charles M. Ferguson, Carolyn C. Compton
Journal: New England Journal of Medicine (1996)

Presentation of CaseA 45-year-old woman (gravida 3, para 0) was admitted to the hospital because of increasing lower abdominal pain.Four weeks before admission, the patient had been seen at another hospital because of lower abdominal pain on urination. A diagnosis of urinary tract infection was made at that time. The symptoms subsided after the administration of trimethoprim–sulfamethoxazole. One week later, she entered the emergency department of this hospital because of persistent lower abdominal pain brought on by lifting objects. The physical examination and laboratory studies were normal.Ten days before admission, the patient returned to the emergency department . . .
MDCT Is Very Useful for Evaluating the Spread of DCIS.
Authors: H. Takayanagi, I. Kimijima, K. Yoshida
Journal: Cancer Research (2009)

Abstract Introduction: Ductal carcinoma in situ (DCIS) may occasionally spread widely in the duct-lobular segment, thereby complicating the complete resection of the lesion in breast-conserving surgery. In order to perform a safe operation for DCIS, the lesion area must be precisely evaluated in the preoperative imaging studies. We performed multidetector-row computed tomography (MDCT) for patients with DCIS and investigated the potential of MDCT for detecting DCIS lesions.Patients and methods: A total of 74 patients with DCIS underwent MDCT. The size of the DCIS lesion in each patient was measured in the volume-rendering view, and these sizes were compared with the lesion sizes obtained by mapping from the pathological tests. The differences between the lengths obtained from pathological tests and those obtained from MDCT (L-path-L-CT) were calculated, and the relationships between the differences and some factors were investigated.Results: Among the 74 DCIS patients who underwent MDCT, DCIS was detected in 61 patients (82.4%). Among these 61 cases, 45.8% were cases of comedo-type DCIS, but the detection rates for comedo and noncomedo cases were not different. The L-path-L-CT values for histological grade I DCIS (1.55 cm) and grade II &amp; III DCIS (0.23 cm) were statistically different. Higher-grade DCIS was more detectable than low-grade DCIS (p = 0.013). Among the other factors, the MDCT assessments and the pathological assessments for comedo-type DCIS and Her-2-positive cases were more consistent than the corresponding results for noncomedo DCIS and Her-2-negative cases. However, these differences were not significant.Conclusion: MDCT shows high efficiency in detecting DCIS. More aggressive types of DCIS, such as higher grade, comedo type, and Her-2-positive DCIS were more precisely detected by MDCT. In comparison with magnetic resonance imaging (MRI), the patient's position during MDCT testing is more similar to that during surgery. Therefore, MDCT is a highly useful presurgical imaging technique for the assessment of DCIS. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5029.
Abstract LB-478: MiRNA as biomarkers to predict d<i>e novo</i> chemoresistance to neoadjuvant chemotherapy in patients with muscle invasive bladder cancer
Authors: Ruth L. Vinall, Clifford Tepper, Alexandra Z.Ripoll, Regina Gandour-Edwards, Blythe Durbin-Johnson, Ralph deVere White
Journal: Cancer Research (2012)

Abstract The primary goal of this study was to determine whether miRNA expression profiling can predict de novo chemoresistance to treatment with neoadjuvant chemotherapy in patients with muscle invasive bladder cancer (MI-BC). The relative expression of 9 miRNAs in 41 annotated, diagnostic MI-BC patient samples was determined by quantitative real-time PCR (qPCR) and correlated with patient response to neoadjuvant chemotherapy, p53 status (SSCP/sequencing) and pRb, p21 expression (IHC). These 9 miRNA were chosen based on a known link to either transitional cell carcinoma (TCC) progression and/or chemoresistance. Expression of these miRNA was also assessed in 8 paired pre- versus post-chemotherapy patient samples from non-responders. Patients with higher let-7c expression levels had significantly higher odds of responding to neoadjuvant chemotherapy (p = 0.023, OR 2.493, 95% CI 1.121, 5.546). The odds of response was not significantly different between patients with vs. without p53 mutations (p = 0.948, OR 0.955, 95% CI 0.231, 3.945). Post-chemotherapy samples expressed significantly higher levels of let-7c (geometric mean ratio = 3.5, P = 0.006). Lower let-7c expression levels appear to predict chemoresistance in TCC patients, prospective studies will be needed to validate this finding. Pre- versus post-chemotherapy patient sample analyses indicate increased let-7c expression plays a role in mediating disease progression following treatment with chemotherapy. Future studies will focus on determining the functional role played by let-7c in chemoresistance and disease progression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-478. doi:1538-7445.AM2012-LB-478