tbuckley/cabot-search huggingface dataset:
Abstract 838: Household stove improvement and lung cancer mortality in Xuanwei, China: A 33-years’ follow-up study
Authors: Wei Jie Seow, Wen-Qing Li, Robert S. Chapman, Wei Hu, Roel Vermeulen, Xingzhou He, Bryan A. Bassig, Christopher Kim, Nathaniel Rothman, Qing Lan
Journal: Cancer Research (2015)

Abstract Background: Household stove improvement from unvented stoves to stoves with chimney (vented stoves) and portable stoves has been shown to reduce lung cancer mortality in our prior cohort study in Xuanwei county, China (1976-1992). It remains unclear whether the protective effects against lung cancer mortality persist over time with extended follow-up (1993-2009). In our study, we examined the associations between vented stove and portable stove use with risk of lung cancer mortality based on a 33 years’ follow-up in Xuanwei. Methods: A total of 42,422 individuals in Xuanwei were retrospectively followed from 1976 through 1992, and prospectively followed to 2009. Extensive information on household stove and fuel use at different age periods during the lifetime was collected in the 1992 and 2009 follow-up surveys. Lung cancer mortality data were obtained by integrating the information from hospital records and death certificates. Multivariable Cox regression models were used to estimate the hazard ratio (HR) of lung cancer mortality associated with stove improvement, adjusting for potential confounders. Results: We observed a significant reduction in lung cancer mortality associated with improvement to vented stoves (multivariate-adjusted HR = 0.43, 95% confidence interval (CI) = 0.40-0.47) and portable stoves (multivariate-adjusted HR = 0.21, 95% CI = 0.19-0.24). There was a monotonic trend towards a decreased risk of lung cancer mortality with increasing years since stove improvement to vented stoves and portable stoves (P-trend for both &amp;lt;0.0001). Similar associations were observed for both men and women. Conclusions: Household stove improvement to both vented stoves and portable stoves were inversely associated with risk of lung cancer mortality. These findings have important public health implications for nearly 3 million people who still use solid fuels for cooking and heating in homes, particularly in developing countries. Citation Format: Wei Jie Seow, Wen-Qing Li, Robert S. Chapman, Wei Hu, Roel Vermeulen, Xingzhou He, Bryan A. Bassig, Christopher Kim, Nathaniel Rothman, Qing Lan. Household stove improvement and lung cancer mortality in Xuanwei, China: A 33-years’ follow-up study. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 838. doi:10.1158/1538-7445.AM2015-838
Early Diagnosis and Successful Treatment of Idiopathic Autoimmune Factor XIII Deficiency Complicated by Intracerebral Hemorrhage
Authors: Mihoko Takai, Naoko Hosono, Shinji Kishi, Takahiro Yamauchi, Yoshimasa Urasaki, Hiroyuki Neishi, Hiroaki Takeuchi, Masaharu Souri, Ken-ichiro Kikuta, Toshihiro Haba, Akitada Ichinose, Takanori Ueda
Journal: Blood (2012)
Abstract 353: Mast Cell Inhibition Attenuates Cardiac Remodeling and Diastolic Dysfunction in Ovariectomized Female Fischer344хBrown Norway Rats
Authors: Hao Wang, Jaqueline da Silva, Allan Alencar, Marina Lin, Xuming Sun, Leanne Groban
Journal: Circulation Research (2015)

Background: The incidence of left ventricular hypertrophy (LVH) and diastolic dysfunction (LVDD) increases in postmenopausal women, but no proven pharmacologic interventions exist. Mast cells have an important role in the pathological processes of a variety of cardiac diseases. We determined the cardioprotective effects of chronic mast cell inhibition by the mast cell stabilizer, cromolyn sodium, in middle-aged, female Fischer344хBrown Norway (F344BN) rats after estrogen (E2) loss. Methods and Results: Bilateral ovariectomy (OVX) or sham-operations were performed in 18-month-old female F344BN rats. Four weeks after surgery, cromolyn (30 mg/kg/day), or vehicle (saline) was administered s.c. by osmotic minipump (n=7/group). Four weeks after treatment, systolic blood pressure (SBP) increased by 20% in OVX vs. sham rats, and cromolyn attenuated this effect. Myocardial relaxation (e’) was reduced (P&lt;0.01), left ventricle (LV) filling pressures (E/e’) were increased (P&lt;0.01), and LV mass, wall thicknesses, and percent interstitial fibrosis were increased in OVX vs. sham rats. All of these adverse effects of E2 loss on LV function and structure were mitigated by cromolyn treatment. While no differences in plasma angiotensin (Ang) II levels were observed between OVX and sham, Ang II levels were reduced in cromolyn-treated OVX rats (P&lt;0.05). Cardiac chymase protein expression was increased after E2 loss, irrespective of cromolyn. Yet, treatment with cromolyn prevented the increase in cardiac Ang II type 1 receptor (AT1aR) mRNA expression with OVX. Conclusions: Mast cell inhibition with cromolyn attenuates adverse LV remodeling and LVDD in OVX-F344BN rats possibly through a chymase/Ang II-mediated mechanism. Cardiac mast cells could be a potential therapeutic target for cardiovascular diseases in postmenopausal women.
Incompatible Inhibitory KIR Ligands Contribute To Lower Survival Rates in Leukemia Patients Receiving T-Replete Hematopoietic Cell Transplants (HCTs).
Authors: J.Y. Sun, A. Dagis, M.M. Miller, J. Longmate, R. Rodriguez, L. Gaidulis, S.J. Forman, D. David
Journal: Blood (2005)
Stimulation of the Mineralocorticoid Receptor by Aldosterone Leads to Activation of HL-60 Neutrophils,
Authors: Carlos E Vazquez, Gregory N Prado, Enrique R Maldonado, Gabriela Saca, Iren M Ortiz, Giselle Brito, Adriana Nieva, Alicia Rivera, Jose R Romero
Journal: Blood (2011)
Recombinant Thrombin Has a Superior Immunogenicity Profile Compared with Bovine Thrombin in a Well-Controlled, Randomized, Double-Blind, Phase 3 Study of Topically Applied Thrombins in Four Surgical Settings.
Authors: Linda A. Zuckerman, Susan Pederson, Dan R. Boster, Lisa Appesland, Dana M. Jackson, Erika Giste, Jonathan D. Newman, Allan Alexander
Journal: Blood (2007)
CC-001 An unusual cause of dyspepsia
Authors: K R Aryal, A Higham, I Crighton, C Ball
Journal: Gut (2010)

<h3>Introduction</h3> Dyspepsia is common presentation in gastrointestinal disease. We report a case of new onset dyspepsia referred for open access gastroscopy who was found to have an unusual cause of the pain. <h3>Methods</h3> Case is reported with investigation results and his subsequent management. <h3>Results</h3> A 63-year-old man was referred for open access gastroscopy for new onset dyspepsia. Gastroscopy under throat spray showed a gall stone in the stomach and what appeared to be a fistulous opening adjacent to the pylorus. Further enquiry, immediately after endoscopy revealed a history of upper abdominal pain 5 years ago following which an abdominal ultrasound detected gall stones. Apart from a raised γ-glutamyl transferase (yGT) of 326 IU/l and slightly raised bilirubin of 20 IU/l, all other liver function tests were normal. An abdominal ultrasound showed gas in the biliary tree; the gall bladder could not be visualised properly and the common bile duct measured 8 mm. A computerised tomography (CT) scan subsequently showed a gall bladder which was adherent to the pylorus with a partially calcified calculus in the gall bladder and gas in the cystic duct and intrahepatic ducts. At operation through a right subcostal incision, the pyloric antrum was densely adherent to the gall bladder and there was a cholecystogastric fistula. Small stones were present in the gall bladder but there were no stones in the stomach. The fistula was taken down and the gastric wall was closed with 2/0 polydioxanone suture. A per-operative cholangiogram showed free flow of contrast to duodenum with no stone on the common bile duct. Cholecystectomy was completed; the post operative period remained uneventful and he was discharged home on the fifth post operative day. Histology of the gall bladder revealed chronic cholecystitis with food debris in the gall bladder in keeping with a diagnosis of cholecystogastric fistula. The fistulation between gall bladder and stomach is very rare and &lt;50 cases of cholecystogastric fistula have been reported in the English literature since 1925. The cholecystogastric fistula is more common in women beyond the sixth decade of life. These cases mostly present with mild dyspepsia, but cases presenting with gastric outlet obstruction and upper gastrointestinal haemorrhage have also been described. The diagnosis is made by gastroscopy, ultrasound or CT scan. <h3>Conclusion</h3> Cholecystogastric fistula is a rare cause of dyspepsia. Removal of the gall bladder with closure of the gastric wall has a good outcome if the patient is fit for operation.
The Gain of the Short Arm of Chromosome 2 (2p+) Induces XPO1 Overexpression and Drug Resistance in Chronic Lymphocytic Leukemia
Authors: Adrien Cosson, Elise Chapiro, Jérome Lambert, Hong-Anh Cung, Caroline Algrin, Frédérik Damm, Clémentine Gabillaud, Frederic Davi, Hélène Merle-Béral, Sylvain Choquet, Madalina Uzunov, Véronique Morel, Veronique Leblond, Karim Maloum, Stéphane Leprêtre, Pierre Feugier, Claude Lesty, Julie Lejeune, Laurent Sutton, Santos A. Susin, Florence Nguyen-Khac
Journal: Blood (2015)
Abstract 3808: Targeting cholesterol for increased chemotherapy efficacy
Authors: Ryuji Yamaguchi
Journal: Cancer Research (2015)

Abstract The PI3K-AKT pro-survival signal present in most cancer cells is the major obstacle to effective chemotherapies. However, most chemotherapeutics targeting the PI3K-AKT pathway have undesirable side effects. β-cyclodextrin (βCD) and its derivatives were found to diminish PI3K-AKT activities in cancer cells with limited side effects. Treatments of cultured cells with βCD depleted cholesterol from the plasma membrane abolishing their coated pits. Even though growth factors such as IGF1 and insulin activated their receptors, their signals were not transduced to downstream signals such as PI3K-AKT pro-survival pathway. The inhibitory effect lasted as long as βCD was present in the medium. Injected into a mouse, βCD attenuated IGF1-induced blood glucose drop for several hours. In the absence of PI3K-AKT pro-survival signal, cells became sensitized to mitochondria dependent cell death such as Bcl2 antagonists ABT-263 in many epithelial cells and Fas and TRAIL in type II cells. In mice carrying human cancer cells, the addition of HPβCD (a derivative of βCD) to the 2-deoxyglucose &amp; ABT-263 combination therapy, and to the TRAIL therapy improved their efficacies. Citation Format: Ryuji Yamaguchi. Targeting cholesterol for increased chemotherapy efficacy. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3808. doi:10.1158/1538-7445.AM2015-3808
Mimicking An Induced Self Phenotype by Coating Lymphomas with the Nkp30-Ligand B7-H6 Promotes Antitumoral Natural Killer Cell Cytotoxicity
Authors: Christian Kellner, Tina Maurer, Daniela Hallack, Roland Repp, Jan G.J. van de Winkel, Paul W.H.I. Parren, Andreas Humpe, Martin Gramatzki, Matthias Peipp
Journal: Blood (2011)
Abstract 5062: Ovarian cancer cells induce the microenvironment changes and subsequently promote disease propagation and dissemination through epithelial-mesenchymal transition and enrichment of tumorigenic cells
Authors: Nanni Huser, Zhengming Yan, Jing Yuan, Cathy C. Zhang
Journal: Cancer Research (2015)

Abstract Ovarian cancer has the highest mortality rate of all gynecological cancers primarily due to the high incidence of metastatic spread prior to diagnosis. Understanding the biology of this malignancy and developing models that reflect the patient disease phenotype will create opportunities for testing targeted therapy. We used the Ovcar 3 cell line to establish a metastasis model through serial in vivo passage. After the treatment of docetaxel and carboplatin, the characteristics of minimal residual disease were assessed. Notably, the stromal environment and tumor initiating subpopulation play critical roles on the Ovcar 3MET disease invasiveness and progression. Compared to the molecular profile of the parental cells, these invasive Ovcar 3MET cells exhibited higher expressions of β-catenin, slug, N-cadherin and ZEB1, suggesting the epithelial-mesenchymal transition in these Ovcar 3MET cells. In addition, a higher fraction of the CD44+/CD24- subpopulation was found in the Ovcar 3MET cells, suggesting enrichment of the tumorigenic population. With the treatment of chemotherapeutic agents, we observed an enrichment of CD44+/CD24- subpopulation in the minimal residual disease. The self-renewal functional analysis demonstrated a higher tumorigenic potential of the MRD cells compared to the cells from vehicle treated mice. In contrast, treatment of the dual PI3K/mTOR inhibitor PF-04691502 resulted in significant anti-tumor and anti-metastatic activities without increasing the MRD self-renewal potential. These results warrant the combination assessment of chemotherapy with targeted agents to reduce or eradicate MRD, therefore to mitigate the risk of disease relapse. Citation Format: Nanni Huser, Zhengming Yan, Jing Yuan, Cathy C. Zhang. Ovarian cancer cells induce the microenvironment changes and subsequently promote disease propagation and dissemination through epithelial-mesenchymal transition and enrichment of tumorigenic cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5062. doi:10.1158/1538-7445.AM2015-5062
Biological and Clinical Significance of CD81 Expression by Clonal Plasma Cells in High-Risk Smoldering and Symptomatic Multiple Myeloma (MM) Patients,
Authors: Bruno Paiva, Norma C. Gutierrez, Xi Chen, María-Belén Vidriales, María-Angeles Montalbán, Laura Rosiñol, Albert Oriol, Joaquín Martínez-López, Maria Victoria Mateos, Lucía López-Corral, Elena Díaz-Rodríguez, Jose J. Perez, Elena Fernandez-Redondo, Felipe de Arriba, Luis Palomera, Enrique Bengoechea, María José Terol, Raquel de Paz, Alejandro Martín, Jose Hernández, Alberto Orfao, Juan José Lahuerta, Joan Blade, Atanasio Pandiella, Jesus F. San Miguel
Journal: Blood (2011)
Elderly Patients with Mantle Cell Lymphoma (MCL) – Efficacy and Feasibility of Prolonged Immunochemotherapy with Rituximab, Cytarabine and Fludarabine Added to CHOP and Followed by Rituximab Maintenance Treatment. A Prospective Study by the Finnish Lymphoma Group
Authors: Erkki Elonen, Riikka Räty, Tuomo Honkanen, Esa Jantunen, Sirkku Jyrkkiö, Marja-Liisa Karjalainen-Lindsberg, Outi Kuittinen, Minna Lehto, Eira Poikonen, Auvo Rauhala, Johanna Rimpiläinen, Anu Räsänen, Sanna Siitonen, Merja Suominen, Mirja Vapaatalo
Journal: Blood (2008)
Methylome evolution in plants
Authors: Amaryllis Vidalis, Daniel Živković, René Wardenaar, David Roquis, Aurélien Tellier, Frank Johannes
Journal: Genome biology (2016)

Despite major progress in dissecting the molecular pathways that control DNA methylation patterns in plants, little is known about the mechanisms that shape plant methylomes over evolutionary time. Drawing on recent intra- and interspecific epigenomic studies, we show that methylome evolution over long timescales is largely a byproduct of genomic changes. By contrast, methylome evolution over short timescales appears to be driven mainly by spontaneous epimutational events. We argue that novel methods based on analyses of the methylation site frequency spectrum (mSFS) of natural populations can provide deeper insights into the evolutionary forces that act at each timescale.
Abstract LB-250: Induction of c-Cbl is a novel mechanism for the anti-cancer effect of HDAC inhibitor in lung cancer
Authors: Chen Ching-Chow, Tzu-Tang Wei, Yu-Chin Lin, Pei-Hua Lin, Jin-Yuan Shih, Chia-Wei Chou
Journal: Cancer Research (2015)

Abstract Here we found loss of c-Cbl, an E3 ligase, expression in Non-small cell lung cancer (NSCLC) compared with its adjacent normal tissue in patient specimens. HDAC inhibition by WJ or knockdown of HDAC 1, HDAC2, HDAC3 or HDAC6 all induced c-Cbl. Ectopic expression of c-Cbl induced decreased EGFR, inhibited growth in NSCLC cells. Knockdown of EGFR inhibited NSCLC growth. Mutation of EGFR at Y1045 decreased WJ-induced growth inhibition as well as in vivo anti-cancer effect and EGFR degradation mediated by WJ. Time-lapse confocal analysis showed co-localization of c-Cbl and EGFR after WJ treatment. Furthermore, WJ inhibited lung tumor growth through c-Cbl induction in orthotopic and tail vein injected models. C-Cbl up-regulation induced by HDACi is a potential strategy for NSCLC treatment. Citation Format: Chen Ching-Chow, Tzu-Tang Wei, Yu-Chin Lin, Pei-Hua Lin, Jin-Yuan Shih, Chia-Wei Chou. Induction of c-Cbl is a novel mechanism for the anti-cancer effect of HDAC inhibitor in lung cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-250. doi:10.1158/1538-7445.AM2015-LB-250
High-Resolution Molecular Allelokaryotyping of Chronic Myeloid Leukemia Patients in Blast Crisis by 6.0 SNP-Arrays Shows a High-Frequency of Uniparental Disomy and Focal Copy Number Alterations Affecting the Whole Sequence or Specific Exons of Oncogenes and Tumor Suppressor Genes.
Authors: Simona Soverini, Sabrina Colarossi, Alessandra Gnani, Fausto Castagnetti, Annalisa Astolfi, Serena Formica, Francesca Palandri, Ilaria Iacobucci, Gabriele Gugliotta, Angela Poerio, Marilina Amabile, Giulia Marzocchi, Nicoletta Testoni, Elisabetta Abruzzese, Gianantonio Rosti, Michele Baccarani, Giovanni Martinelli
Journal: Blood (2009)
Abstract 3618: SGKs survival signal via inhibition of pro-apoptotic Mixed Lineage Kinase 3 (MAP3K11) in cancer cells
Authors: Gautam V. Sondarva, Velusamy Rangasamy, Navin Viswakarma, Subhasis Das, Rakesh Sathish Nair, Basabi Rana, Ajay Rana
Journal: Cancer Research (2015)

Abstract Survival of cancer cells requires activation of pro-survival and inhibition of pro-apoptotic pathways in concert. It is utmost important to understand the underlying molecular pathways that regulate cancer cell survival and death, so that specific inhibitor could be identified and used to target cancer cell death pathways. Dexamethasone (DEX) is routinely administered to cancer patients, in order to reduce allergic responses. It is reported that DEX use in certain cancer patients could lead to early cancer relapse and detrimental. Earlier, we reported that insulin regulated PI3K-AKT pathway down regulated pro-apoptotic Mixed Lineage Kinase 3 (MLK3) and this down regulation of kinase activity, favored cancer cell survival. Since SGK family members are also regulated by PI3K via Glucocorticoid Receptor (GR) in response to DEX, and SGK is reported to have similar function like AKT, we hypothesized that SGKs might also regulate pro-apoptotic function of MLK3, similar to AKT but probably via a non-redundant pathway. Here we report that MLK3 is a direct target of SGK in cancer cells. Endogenous SGK physically associated with and phosphorylated MLK3 in HepG2 cells and this interaction was regulated by synthetic glucocorticoid, dexamethasone. JNK and MLK3 kinase activities were significantly inhibited either by over expression of SGK3 or by dexamethasone. The SGK3 and dexamethasone-mediated attenuation of MLK3, MKK7 and JNK kinase activities were blocked by PI3K inhibitor, LY294002, suggesting a link between PI3K-SGK and MLK3-JNK signaling pathways. SGK phosphorylated MLK3 both in vivo and in vitro. SGK1 and SGK2/3 phosphorylated MLK3 on Ser674 and Thr738, respectively. Furthermore, SGK3 inhibited MLK3-mediated cell death and JNK kinase activity in a manner, dependent on Thr738 phosphorylation of MLK3. Taken together, these data define the mechanisms of glucocorticoid-mediated inhibition of MLK3-JNK axis and cell death pathways. Furthermore, our data also identify MLK3 as an indirect target of glucocorticoids that might play a significant role in the pro-survival and anti-inflammatory actions of glucocorticoid in cancer cell. Therefore, it is conceivable that targetting MLK3 with its agonist, ceramide (by nano-ceramide particles) could possibly overcome DEX-induced cancer relapse. This work is supported by VA Grant #: BX000312 and NIH, R01 CA 176846 to AR; and VA Grant #: BX000571to BR. Citation Format: Gautam V. Sondarva, Velusamy Rangasamy, Navin Viswakarma, Subhasis Das, Rakesh Sathish Nair, Basabi Rana, Ajay Rana. SGKs survival signal via inhibition of pro-apoptotic Mixed Lineage Kinase 3 (MAP3K11) in cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3618. doi:10.1158/1538-7445.AM2015-3618
Does severe toxicity affect global quality of life in patients with metastatic colorectal cancer during palliative systemic treatment? A systematic review
Authors: C.S.E.W. Schuurhuizen, A.M.J. Braamse, I.R.H.M. Konings, M.A.G. Sprangers, J.C.F. Ket, J. Dekker, H.M.W. Verheul
Journal: Annals of Oncology (2016)
HSP70 Inhibitor, YK5, Ablates Blast, Progenitor and Stem Cell Populations in Primary Acute Myelogenous Leukemia Cells
Authors: Juan Felipe Rico, Krishan K. Sharma, Yanlong Kang, Tony Taldone, Hardik Patel, Sarah Brennan, Hongliang Zong, Michael W. Becker, Gail J. Roboz, Gabriela Chiosis, Monica L. Guzman
Journal: Blood (2011)