tbuckley/cabot-search huggingface dataset:
Abstract 2652: Detection of Transient Regional Myocardial Ischaemia in the Emergency Department Using a Novel Modification of Body Surface Electrocardiac Mapping is Superior to the Conventional 12 Lead ECG
Authors: Monique Robinson, Clare Bannister, Richard Reddiar, Nicholas Curzen
Journal: Circulation (2008)

Diagnosing transient regional myocardial ischaemia (TRMI) in patients presenting to the Emergency Department (ED) with acute chest pain is a challenge. The 12 lead ECG has established limitations and Troponin, though sensitive, is less reliable when used within 12 hours of symptom onset. The PRIME ECG Delta map is derived from 80 electrode electrocardiographic surface maps acquired (a) during chest pain and (b) when pain resolves. ST segment differences between scans are then displayed as colour changes on a torso map. In addition, the Ischaemic Burden (IB) - an index of the total extent of myocardial ischaemia -may be derived from the Delta Map. Objectives: In a cohort presenting with cardiac-sounding chest pain: 1.To compare the sensitivity and specificity of the PRIME Delta map and the 12 lead ECG for the diagnosis of TRMI using coronary angiography as a diagnostic gold standard. 2. To evaluate whether the IB is a valuable diagnostic tool and examine its relationship with Troponin. Methods: 80 lead ECGs were acquired for subjects with suspected TRMI when in pain and once pain free and a Delta Map derived. The IB was calculated as the sum of ST segment shift across all 80 electrodes. Subjects then underwent coronary angiography as clinically appropriate. Results: For 51 adults studied, the PRIME Delta Map was more sensitive for the detection of TRMI than the 12 lead ECG 93% vs. 81%, p 0.04. The Delta map was also more specific for TRMI 57% vs. 29%, p= 0.03.The Delta map was superior to the 12 lead particularly for detecting lateral and posterior regions of TRMI 100 % detection vs. 75%, p= 0.02. The IB correlated with peak Troponin (r= 0.52, p= 0.0001) and was significantly higher in patients with STEMI compared to NSTEMI. ROC curve evaluation of the IB showed it was an accurate measure of myocardial ischaemia with Area Under the Curve of 0.6 (95% CI 0.38 – 0.84) Conclusion: The PRIME ECG Delta map is a near patient, rapid, accurate and intuitive method for detecting TRMI and is superior to the 12 lead ECG. The IB derived from the Delta map might be a useful early surrogate for Troponin in patients with suspected TRMI. Used together, the Delta Map and IB could potentially facilitate more rapid identification and appropriate treatment in patients with coronary artery disease.
Case 40-1971
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, David V. Bates, Gerald Nash
Journal: New England Journal of Medicine (1971)

Presentation of CaseA 47-year-old woman was admitted to the hospital because of fever.Two and a half years earlier she entered the hospital because of intestinal obstruction. The white-cell count was 350,000, with a predominance of polymorphonuclear cells, myelocytes and metamyelocytes. Laparotomy disclosed a granulocytic sarcoma secondary to chronic myelocytic leukemia; the mass was excised, together with a small portion of nonviable bowel. A course of radiation treatment was directed to the peritoneal cavity, and the white-cell count fell to the range of 10,000 to 20,000. Nineteen months before admission the white-cell count rose to 70,000, and busulfan, 2 . . .
Outbreak of salmonellosis in a restaurant in Stockholm, Sweden, September – October 2006
Authors: B de Jong, J Öberg, B Svenungsson
Journal: Eurosurveillance (2007)

The largest outbreak of salmonellosis in 25 years in Stockholm County occurred during September - October 2006. A total of 115 persons who had a meal at a restaurant in Stockholm were notified as cases of salmonellosis through the Swedish surveillance system. The probable vehicle of the outbreak was mung beans, soaked in lukewarm water for 24 hours before being served at the restaurant. These mung beans had been included in all dishes served in the restaurant and the outbreak was terminated when they were excluded from the menu. Either Salmonella Bareilly or Salmonella Virchow were isolated from affected persons. No person was found to have an infection with both serotypes. The majority of affected persons were females with a median age of 34 years.This and similar outbreaks associated with consumption of vegetables and fruits highlight the increasing importance of fresh produce as vehicle for foodborne outbreaks in Europe.
Fibrolamellar hepatocellular carcinoma と硬化型肝細胞癌の臨床病理学的特徴と諸問題：病理診断医間に存在する硬化型肝細胞癌組織診断基準の差異に関する現状報告も兼ねて
Authors: 尾島英知
Journal: Liver Cancer (2009)
Continuous laryngoscopy quantitates laryngeal behaviour in exercise and recovery
Authors: J. Tod Olin, Matthew S. Clary, Elizabeth M. Fan, Kristina L. Johnston, Claire M. State, Matthew Strand, Kent L. Christopher
Journal: European Respiratory Journal (2016)

Exercise-induced laryngeal obstruction (E-ILO) causes exertional dyspnoea. There is no standardised methodology which characterises laryngeal obstruction in relation to exercise or links laryngeal obstruction and dyspnoea severity. Continuous laryngoscopy during exercise (CLE) may improve diagnostic sensitivity by enabling laryngeal visualisation at peak work capacity in patients with rapidly resolving obstruction. The time course of laryngeal obstruction across exercise and recovery has not been quantitated until this report. Adolescents and young adults referred for CLE were laryngoscopically monitored across rest, maximal cycle ergometry exercise, and recovery. Three reviewers, blinded to time sequencing, rated inspiratory glottic and supraglottic obstruction during 10 windows of 15-s corresponding to rest, 25%, 50%, 75%, 90% and 100% of individual symptom-limited peak work capacity (expressed in Watts), and four consecutive recovery windows. 85 patients were screened and 71 included. Over 96% of time windows were interpretable. Laryngeal obstruction severity reached observed maximal levels at peak work capacity, and rapidly resolved. A spectrum of observed maximal obstruction was measured. CLE provides interpretable data demonstrating laryngeal obstruction in patients with suspected E-ILO that is more severe at peak work capacity than during rest, submaximal exercise, or recovery. Observed maximal obstruction was infrequently severe and rapidly resolved.
Results of the “Evaluation of NGS in AML-Diagnostics (ELAN)” Study – an Inter-Laboratory Comparison Performed in 10 European Laboratories
Authors: Christian Thiede, Lars Bullinger, Jesús M Hernández-Rivas, Michael Heuser, Claude Preudhomme, Steven Best, Dolors Colomer, Francesco Lo Coco, Giovanni Martinelli, Anna Schuh, Rocí­o Benito, Anna Dolnik, Anna Enjuanes, Sandrine Geffroy, Serena Lavorgna, Nicholas Lea, Joanne Mason, Emanuela Ottaviani, Anne Otto, Felicitas Thol, Sabin Bhuju, Konstanze Döhner, Christian Eberlein, Angela Hamblin, Olivier Nibourel, Tiziana Ottone, Maria Antonella Laginestra, Marta Pratcorona, Mónica del Rey, Felix Schlesinger
Journal: Blood (2014)
Novel Anticancer Agents Based on Targeting the Trimer Interface of the PRL Phosphatase
Authors: Yunpeng Bai, Zhi-Hong Yu, Sijiu Liu, Lujuan Zhang, Ruo-Yu Zhang, Li-Fan Zeng, Sheng Zhang, Zhong-Yin Zhang
Journal: Cancer Research (2016)

Phosphatase of regenerating liver (PRL) oncoproteins are phosphatases overexpressed in numerous types of human cancer. Elevated levels of PRL associate with metastasis and poor clinical outcomes. In principle, PRL phosphatases offer appealing therapeutic targets, but they remain underexplored due to the lack of specific chemical probes. In this study, we address this issue by exploiting a unique property of PRL phosphatases, namely, that they may function as homotrimers. Starting from a sequential structure-based virtual screening and medicinal chemistry strategy, we identified Cmpd-43 and several analogs that disrupt PRL1 trimerization. Biochemical and structural analyses demonstrate that Cmpd-43 and its close analogs directly bind the PRL1 trimer interface and obstruct PRL1 trimerization. Cmpd-43 also specifically blocks the PRL1-induced cell proliferation and migration through attenuation of both ERK1/2 and Akt activity. Importantly, Cmpd-43 exerted potent anticancer activity both in vitro and in vivo in a murine xenograft model of melanoma. Our results validate a trimerization-dependent signaling mechanism for PRL and offer proof of concept for trimerization inhibitors as candidate therapeutics to treat PRL-driven cancers. Cancer Res; 76(16); 4805-15. ©2016 AACR.
Psychometric Performance Of The EORTC Quality-Of-Life Core Questionnaire (QLQ-C30) and QLQ-Multiple Myeloma (QLQ-MY20) In Relapsed/Refractory Multiple Myeloma (RRMM)
Authors: Xavier Leleu, Maria Teresa Petrucci, Manfred Welslau, Isabelle Vande Broek, Philip T Murphy, Andrew Bottomley, Pamela Bacon, Philip Lewis, Hélène Gilet, Benoit Arnould, Charalampia Kyriakou
Journal: Blood (2013)
A phase III randomised controlled trial of single-dose triple therapy in COPD: the IMPACT protocol
Authors: Steven J. Pascoe, David A. Lipson, Nicholas Locantore, Helen Barnacle, Noushin Brealey, Rajat Mohindra, Mark T. Dransfield, Ian Pavord, Neil Barnes
Journal: European Respiratory Journal (2016)

Patients with symptomatic advanced chronic obstructive pulmonary disease (COPD) who experience recurrent exacerbations are particularly at risk of poor outcomes and present a significant burden on healthcare systems. The relative merits of treating with different inhaled combination therapies e.g. inhaled corticosteroids (ICS)/long-acting β2-agonist (LABA), LABA/long-acting muscarinic antagonists (LAMA), ICS/LABA/LAMA, in this patient group are poorly understood, as is reflected in current guidelines. The InforMing the PAthway of COPD Treatment (IMPACT) study will evaluate the efficacy and safety of fluticasone furoate (FF)/umeclidinium (UMEC)/vilanterol (VI) versus FF/VI or UMEC/VI over a 52-week treatment period. The study has been designed with a focus on understanding the comparative merits of each treatment modality in different phenotypes/endotypes.This is a phase III, randomised, double-blind, three-arm, parallel-group, global multicentre study comparing the rate of moderate and severe exacerbations between FF/UMEC/VI and FF/VI or UMEC/VI over a 52-week treatment period. The study aims to recruit 10 000 patients from approximately 1070 centres. Eligible patients are aged ≥40 years, with symptomatic advanced COPD (Global initiative for chronic Obstructive Lung Disease (GOLD) group D) and an exacerbation in the previous 12 months.The first patients were recruited to the IMPACT study (ClinicalTrials.gov: NCT02164513) in June 2014 and the anticipated completion date is July 2017.
Idelalisib Impacts Cell Growth through Inhibiting Translation-Regulatory Mechanisms in Mantle Cell Lymphoma
Authors: Qingshan Yang, Lisa S. Chen, Min Jin Ha, Kim-Anh Do, Sattva S. Neelapu, Varsha Gandhi
Journal: Clinical Cancer Research (2016)

PI3K is a critical node in the B-cell receptor pathway, which is responsible for survival and proliferation of B-cell malignancies. Idelalisib, a PI3Kδ-isoform-specific inhibitor, has been approved to treat B-cell malignancies. Although biological activity of the drug has been evaluated, molecular mechanisms and signaling pathway disruption leading to the biological effects of idelalisib are not yet well defined. Prior laboratory reports have identified transcription and translation as the primary events for attenuation of PI3Kα isoform. We hypothesized that PI3Kδ-isoform inhibition by idelalisib should also affect gene transcription and protein translation.Using three mantle cell lymphoma cell lines and primary cells from patients, biological consequences such as apoptosis/cell-cycle analysis, as well as RNA/protein synthesis were evaluated. Proteomics analyses (RPPA and immunoblot assays) defined molecular events downstream of PI3K/AKT cassette.Idelalisib treatment resulted in inhibition of protein synthesis, which correlated with reduction in cell size and cell growth. A moderate loss of viability without any change in cell-cycle profile was observed. Idelalisib treatment inhibited AKT activation, an immediate downstream PI3K effector, and also reduced phosphorylation levels of downstream AKT/mTOR pathway proteins such as PRAS40. In addition, idelalisib treatment impeded activation of the MAPK pathway, and MEK, ERK and p90RSK phosphorylation levels were reduced. Reduction in AKT, PDK1, and MEK phosphorylation correlated with protein synthesis inhibition.Collectively, these results clarify the molecular mechanisms of actions and may provide biomarkers and targets for combination with idelalisib in B-cell malignancies. Clin Cancer Res; 23(1); 181-92. ©2016 AACR.
Circulating Tumor Cell Isolation: Efficient Purification and Release of Circulating Tumor Cells by Synergistic Effect of Biomarker and SiO<sub>2</sub>@Gel-Microbead-Based Size Difference Amplification (Adv. Healthcare Mater. 13/2016)
Authors: Qinqin Huang, Bo Cai, Bolei Chen, Lang Rao, Zhaobo He, Rongxiang He, Feng Guo, Libo Zhao, Kiran Kumar Kondamareddy, Wei Liu, Shishang Guo, Xing-Zhong Zhao
Journal: Advanced Healthcare Materials (2016)

Efficient high-purity recovery of viable circulating tumor cells (CTCs) allows the detection and characterization of cancer. On page 1554, W. Liu, S. S. Guo, X.-Z. Zhao, and co-workers describe a microfluidics-based CTC-isolation approach using CTC-specific antibodies conjugated to silica microbeads. Continuous-flow purification of CTCs is realized by laminar-like interfaces. Based on a cell capture and release platform, viable cancer cells can be isolated from CTC blood samples. The low-cost yet effective method is promising for point-of-care pharmacotherapy.
Early onset breast cancer in black women of african ancestry: Genetic or environmental influence?
Authors: Foluso Ademuyiwa, Susan Neuhausen, Clement Adebamowo, Temitope Ogundiran, Charles Rotimi, Susan Colilla, Lise Sveen, Gail Tomlinson, Olufunmilayo Olopade
Journal: Cancer Research (2005)

3227  Purpose: Screening mammography in minority-underserved and low income women has limited efficacy and is associated with poorer breast cancer outcomes. We hypothesized that the health attitudes, beliefs and habits of these women affect breast cancer screening practice. Methods: Minority-underserved and low income women who had recently completed treatment for breast cancer were interviewed, at the Stroger Hospital of Cook County, Minority-Based Community Clinical Oncology Program (MBCCOP), which serves the medically-indigent in Chicago. Data was collected using the Multidimensional Health Profile (PAR, Inc.) as an instrument for evaluation of health attitudes, beliefs and habits, and analysis was performed on the following areas: Negative Health Habits (NHH), Positive Health Habits (PHH), Professional Help (PRH), Spiritual Help (SPH), Self-Efficacy (EFF) and Hypochondriasis (HYP). Data on patterns of screening practice were obtained from clinical records and analysis was performed using logistic regression. Results: A total of 115 women age 45 and older were interviewed, and 71 (61.7%) were African-American (AA). Screening mammography was evident for only 48 (41.7%) women. Univariate analysis did not demonstrate correlation between screening practice and education level, marital status, body mass index, NHH (includes poor nutritional habits, lack of exercise, substance abuse, smoking, and excessive alcohol use), SPH and EFF. However, there was significant correlation with race, age, PHH, PRH and HYP. Multivariate analysis demonstrated that race was not a predicting factor for screening. However, women with increased PHH, PRH, and HYP scores were significantly more likely to screen (Odds Ratio/p-value 1.07/0.0001, 1.30/0.0028, and 1.06/0.0128 respectively). Women who had screening mammograms were more likely to be concerned about strenuous exercise (34.9%), food intake and monitoring of calories (32.4%), and reading material concerning health care (32.4%). These women were also very likely to follow medical advice (41.2%) and strongly agreed that they worry about health, despite physician reassurance (74.6%). AA women rated lower on the same questions (p=0.3). Conclusions: Adherence to screening mammography recommendations among minority-underserved and low income women is more likely to be observed when these women have positive health habits, believe in professional help, and maintain concern about their health status. Efforts to improve screening practice for these women need to incorporate methods to promote positive health attitudes, beliefs and habits.
Measuring and Improving Quality—Reply
Authors: Elizabeth A. McGlynn, Eve A. Kerr
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Transcriptome-Wide Analysis of Bone Marrow CD19+ Cells As Well As Bone Marrow B Cell Clones of Waldenström's Macroglobulinemia (WM) Vs. IgM Monoclonal Gammopathy of Undetermined Significance (IgM-MGUS)
Authors: Alessandra Trojani, Antonino Greco, Alessandra Tedeschi, Milena Lodola, Barbara Di Camillo, Anna Maria Frustaci, Enrica Morra
Journal: Blood (2014)
Application of a standard practice-based system to measure and compare quality of cancer survivorship care.
Authors: Guadalupe R. Palos, Katherine Ramsey Gilmore, Patricia Chapman, Paula A. Lewis-Patterson, Maria Alma Rodriguez
Journal: Journal of Clinical Oncology (2016)

239 Background: Despite the growing committment to improve survivorship care, measuring its quality remains difficult. In 2006, the American Society of Clinical Oncologists (ASCO) launched a practice-based system known as the Quality Oncology Practice Initiative (QOPI) to measure the quality of cancer care. Here, we demonstrate the use of QOPI procedures to compare compliance with survivorship care plans (SCPs) across different disease-specific clinics. Methods: Measures based on survivorship clinical practice guidelines were abstracted from SCPs issued to survivors scheduled for appointments in site-specific clinics. Following QOPI procedures, we identified the target condition as cancer, selected data collection methods, and determined core measures for abstraction. Procedures included; identifying the number of survivors arriving for appointments within the specified time period, standardizing denominators and numerators used per clinic, determining the number of full-time providers per clinic, and calculating the number of records to audit per clinic. All data were obtained from completed care plans, institutional electronic medical records, and scheduling systems. Descriptive statistics were used to conduct aggregate analyses of de-identified data. The same procedures were followed in each clinic. Results: From September 1, 2014, to August 31, 2015, we used a standard process to assess compliance for issuing survivorship care plans across 9 clinics. There were a total of 8864 arrived appointments; 46 providers completed a total of 7448 electronic survivorship care plans over the time period. Analysis of compliance rates indicated broad variation across clinics, including: breast (85.3%), gastrointestinal (80.2%), genitourinary (88.5%), gynecology (78.6%), head/neck (96.8%), lymphoma (99.3%), melanoma (62.2%), thyroid (75.4%) and thoracic (63.3%). Conclusions: Establishing uniform procedures, such as the QOPI process, to measure and compare compliance with SCPs will help achieve high quality standards of care for long-term cancer survivors. Further examination is warranted to determine longitudinal trends and factors contributing to variation in compliance rates.
Incidence of Severe Infections and Infection‐Related Mortality During the Course of Giant Cell Arteritis: A Multicenter, Prospective, Double‐Cohort Study
Authors: Jean Schmidt, A. Smail, B. Roche, P. Gay, V. Salle, H. Pellet, Pierre Duhaut
Journal: Arthritis & Rheumatology (2016)

To assess the incidence of infections leading to hospitalization, the mortality rate related to infections, and the determinants of these factors in patients with giant cell arteritis (GCA).In total, 486 patients with GCA (75% women) were enrolled at the time of diagnosis. All patients fulfilled the American College of Rheumatology criteria for GCA. As controls, age- and sex-matched subjects were randomly selected from the general population and matched to patients at the time of diagnosis of GCA. Both groups were prospectively followed up over a 5-year period.Severe infections were more frequent among patients with GCA during the first year after diagnosis, compared to general population controls (incidence rate ratio 2.1, 95% confidence interval [95% CI] 1.2-3.4; incidence rate 11.1/100 patient-years [95% CI 8.3-14.6] in patients with GCA versus 5.9/100 patient-years [95% CI 4-8.4] in controls). Specifically, septic shock and infectious colitis were more frequent among the patients with GCA. Mortality caused by infections was higher in patients with GCA compared to controls (P < 0.0001 by log rank test). In analyses adjusted for age, among patients with GCA, a diagnosis of diabetes (hazard ratio [HR] 3.3, 95% CI 1.4-7.7) and a corticosteroid dosage that was >10 mg/day after 12 months of treatment (HR 4.61, 95% CI 1.38-15.36) were associated with death attributed to severe infection. The observed overall incidence of mortality was increased in patients with GCA during the early period of enrollment in the study (before 1997) (P = 0.0001 by log rank test), but thereafter was the same as that in the general population controls.Frequencies of severe infections and rates of infection-related mortality are increased during the first year after the diagnosis of GCA. The risk of infection increases in GCA patients with older age or in the presence of diabetes, or is greater when the dosage of corticosteroids has been increased to >10 mg/day after 12 months of treatment.