tbuckley/cabot-search huggingface dataset:
Analysis of head impact exposure and brain microstructure response in a season-long application of a jugular vein compression collar: a prospective, neuroimaging investigation in American football
Authors: Gregory D Myer, Weihong Yuan, Kim D Barber Foss, Staci Thomas, David Smith, James Leach, Adam W Kiefer, Chris Dicesare, Janet Adams, Paul J Gubanich, Katie Kitchen, Daniel K Schneider, Daniel Braswell, Darcy Krueger, Mekibib Altaye
Journal: British Journal of Sports Medicine (2016)

Background Historical approaches to protect the brain from outside the skull (eg, helmets and mouthpieces) have been ineffective in reducing internal injury to the brain that arises from energy absorption during sports-related collisions. We aimed to evaluate the effects of a neck collar, which applies gentle bilateral jugular vein compression, resulting in cerebral venous engorgement to reduce head impact energy absorption during collision. Specifically, we investigated the effect of collar wearing during head impact exposure on brain microstructure integrity following a competitive high school American football season. Methods A prospective longitudinal controlled trial was employed to evaluate the effects of collar wearing (n=32) relative to controls (CTRL; n=30) during one competitive football season (age: 17.04±0.67 years). Impact exposure was collected using helmet sensors and white matter (WM) integrity was quantified based on diffusion tensor imaging (DTI) serving as the primary outcome. Results With similar overall g-forces and total head impact exposure experienced in the two study groups during the season (p&gt;0.05), significant preseason to postseason changes in mean diffusivity, axial diffusivity and radial diffusivity in the WM integrity were noted in the CTRL group (corrected p&lt;0.05) but not in the collar group (p&gt;0.05). The CTRL group demonstrated significantly larger preseason to postseason DTI change in multiple WM regions compared with the collar group (corrected p&lt;0.05). Discussion Reduced WM diffusivity alteration was noted in participants wearing a neck collar after a season of competitive football. Collar wearing may have provided a protective effect against brain microstructural changes after repetitive head impacts. Trial registration number NCT02696200.
Subjective awareness of abnormal involuntary movements in chronic schizophrenic patients
Authors: G Caracci, S Mukherjee, S D Roth, P Decina
Journal: American Journal of Psychiatry (1990)

The authors examined the effects of verbal and visual feedback on subjective awareness of involuntary movements in 20 chronic schizophrenic patients. At initial evaluation only 25% of the patients were fully aware of their movement disorder. Both verbal and visual feedback resulted in significant immediate enhancement of awareness. However, assessment of awareness 2 weeks later showed a return to prefeedback baseline levels. Lack of awareness of involuntary movements was associated with a lack of awareness of psychiatric disorder, and both were associated with a longer duration of illness.
Gene profiling should be offered to some patients with breast cancer, says NICE
Authors: Jacqui Wise
Journal: BMJ (2016)

Patients with a type of early breast cancer who are at risk of it spreading should be offered gene expression profiling to help personalise treatment decisions, the National Institute for Health and Care Excellence (NICE) has said.1

The updated NICE quality standard says that people with oestrogen receptor positive (ER positive), human epidermal growth factor receptor 2 negative (HER2 negative), or lymph node negative early breast cancer who are at intermediate risk of distant recurrence should be offered the Oncotype DX test. The test provides information about the genetic make-up of the …
Synchronization of Events in Fused Interphase-Metaphase Binucleate Cells: Progression of the Telophase-Like Nucleus2
Authors: Yoshitaka Obara, Lee S. Chai, Herbert Weinfeld, Avery A. Sandberg
Journal: JNCI Journal of the National Cancer Institute (1974)

After the initial formation of nuclear envelopes around the metaphase chromosomes and the production of a telophase-like nucleus (TLN) 30 minutes after metaphase- interphase cell fusion, the chromatin of the TLN underwent structural and functional changesthat resembled the progression of a telophase nucleus in the normal cell cycle. To identify the metaphase chromatin, metaphases prelabeled with 3H-thymidine were fused with unlabeled interphase cells. Light microscopy of the TLN, up to 60 minutes after the initial formation, revealed a gradual loss of chromatid structure; by 60 minutes, the chromatin resembled that of interphase. Concomitantly, the number of recognizable TLN's fell, which was matched by an increase in the number of binucleate interphase-interphase cells containing only 1 radiolabeled nucleus. Electron microscopy revealed progressive formation of nucleolilike bodies and, 60 minutes after TLN formation, areas of decondensed chromatin. The ability of the TLN to incorporate 3H-uridine into its chromatin during its progression revealed a temporal pattern similar to that of the metaphase-G1 progression in the normal cell cycle. The progression of the TLN is another example of intracellular synchronization of cell cycle stages in virus-fused cell.
Impact of chemotherapy partner on efficacy of targeted therapy in metastatic colorectal cancer (mCRC): A meta-analysis.
Authors: David Chan, Nick Pavlakis, Timothy Jay Price, Christos Stelios Karapetis, Niall C. Tebbutt, Jeremy David Shapiro, Eva Segelov
Journal: Journal of Clinical Oncology (2014)

3552 Background: In metastatic colorectal cancer (mCRC), the question of whether efficacy of targeted therapy is affected by chemo partner remains unresolved. Studies of chemotherapy (chemo) added to epidermal growth factor receptor (EGFR) inhibitors (EGFRI: cetuximab, panitumumab) and anti-vascular endothelial growth factoragents (VEGF) (bevacizumab, aflibercept) have reported mixed outcomes. We undertook systematic review to explore efficacy of these combinations according to chemotherapy partner. Methods: Randomized controlled trials were sought evaluating the combination of chemo with targeted therapy, categorized according to therapy class (EGFR or VEGF) and chemo partner (oxaliplatin (ox) or irinotecan (iri)). The impact of fluoropyrimidine (FP) regimen (bolus, infusional, or oral) was also explored. Only KRAS exon 2 wild type (WT) subpopulations were included in EGFR analysis. The primary endpoint was overall survival (OS) with secondary endpoints of progression-free survival (PFS), overall response rate (ORR) and toxicity. Meta-analysis was performed according to CONSORT guidelines and standard methods with hazard ratios (HR) and odds ratios (OR) computed. Results: We identified 21 trials evaluating 9,629 patients. For EGFRI, OS (eight trials, 3,499 pts) was improved in combination with iri, HR 0.87 (95% CI 0.78-0.97) but not ox with HR 1.01 (95% CI 0.91-1.13). PFS (n=3473) was also improved with iri with HR 0.74 (95% CI 0.65-0.83) but not ox (HR 0.92, 95% CI 0.83-1.02). Overall response rate (n=3436) OR for iri was 3.09 (95% CI 2.47-3.86) and OR for ox was 1.36 (95% CI 1.12-1.64). The iri-ox interaction p-value was 0.07 for OS, 0.006 for PFS and <0.00001 for ORR. Overall grade 3/4 (all toxicity) OR for iri was 2.53 (95% CI 2.06-3.11) and ox OR 1.89 (95% CI 1.40-2.54). Two trials (n=151) directly compared iri-EGFRI with ox-EGFRI. No significant differences in efficacy were observed. For anti-VEGF therapy (11 studies, 5,290 pts), there was no significant difference in OS, PFS, ORR or toxicity according to chemo regimen used. The choice of FP did not affect efficacy. Conclusions: The meta-analysis shows superior efficacy when EGFRI are combined with irinotecan-based chemo regimens compared to oxaliplatin-based regimens. Chemo interaction was not observed with anti-VEGF therapy.
Genomic hallmarks of invasive lobular breast carcinoma and their clinical relevance
Authors: G. Zoppoli, G. Gundem, G. Pruneri, D. Larsimon, M. Fornili, D. Fumagalli, D. Brown, R. Salgado, T. Van Brussel, D. Lambrechts, R. Bose, O. Metzger, C. Galant, F. Bertucci, M. Piccart, E. Biganzoli, G. Viale, P.J. Campbell, C. Sotiriou, C. Desmedt
Journal: Annals of Oncology (2015)
Case 3-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Peter N. Riskind, Edward P. Richardson
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 19-year-old man was admitted to the hospital because of painful ophthalmoplegia.He was well until one month earlier, when his automobile skidded and collided with a tree, and his forehead struck the wheel. He did not lose consciousness. During the next two days he experienced dizziness, without nausea, vomiting, headache, or visual problems. Two weeks before admission he awoke in the middle of the night with a severe right frontal and periorbital headache that radiated into the right upper molar region, lasted 10 to 15 minutes, and was accompanied by drooping of the right upper lid, . . .
Proctitis cystica profunda diagnosed by endoscopic submucosal dissection: use of a therapeutic procedure for diagnosis
Authors: Jérémie Jacques, Laura Mesturoux, Paul Carrier, Tessa Tabouret, Veronique Loustaud-Ratti, Denis Sautereau, Romain Legros
Journal: Endoscopy (2015)

A 54-year-old woman was referred to our gastroenterology unit after discovery of an atypical submucosal rectal lesion. She had developed massive hematochezia 1 month previously. Colonoscopy revealed 3-cm discrete submucosal lesions with superficial mucosal inflammation ([Fig. 1]). Pathologic analysis of a superficial biopsy specimen was inconclusive. Two successive rectal endoscopic ultrasonographic examinations were performed with a 1-month interval, and hypoechoic cystic lesions of the submucosal layer (third hyperechoic layer) were discovered ([Fig. 2]). All submucosal lesions had the same ultrasonographic features, but one exhibited a hyperechoic area with acoustic shadowing typical of calcification ([Fig. 3]). Endoscopic biopsies were again inconclusive, and endoscopic ultrasound guided-fine needle aspiration (EUS-FNA) was not performed because of the high risk of infection. Instead, we performed endoscopic submucosal dissection of one lesion to obtain a complete pathological analysis ([Video 1], [Fig. 4]). A diagnosis of proctitis cystica profunda was made based on typical pathological features ([Fig. 5] and [Fig. 6]).
Abstract 327: A Comprehensive Echocardiogram Study in Postural Orthostatic Tachycardia Syndrome
Authors: Chandralekha Ashangari, Amer Suleman, Asheki Brown
Journal: Circulation Research (2015)

Background and Purpose: The Postural Orthostatic Tachycardia Syndrome (POTS) affects primarily young women. POTS is a form of dysautonomia affecting millions around the world. The aim of this study is to determine the echocardiographic findings in POTS patients. Methods: 173 POTS patients were randomly selected and underwent echocardiogram results were reviewed and performed cumulative distribution of echocardiogram results in to top 10 percentile to see the abnormalities. Results: Out of 173 patients, 96% are females (n=166; age 29.20 ± 9.26), 4% are males (n=7; age 28.50 ± 13.64) Our findings (mean ± SD). RVDD (2.37 cm ± 0.30 cm), LVED (4.34 cm ± 0.35 cm), IVS (0.82 cm ± 0.12 cm), LVEF (63.7%±2.61%), LVES (2.93 cm ± 0.25 cm), LVPW (0.83 cm ± 0.13 cm) , LVOT Dia (1.82 cm ± 0.20 cm) AO Root (2.70 cm ± 0.31 cm) , LA Dia ( 3.13 cm ± 0.36 cm) ,AV Vel (1.12 m/sec ± 0.13 m/sec), LVOT Vel (0.83 m/sec ± 0.31 m/sec), Mean Gradient (2.81mmHg ± 0.68 mmHg), Peek Gradient (4.91 mmHg ± 1.40 mmHg), AVA (2.65 cm2 ± 0.44 cm2),E Vel (0.77 m/sec ± 0.13 m/sec), A Vel (0.54 m/sec ± 0.10 m/sec), E/A Ratio (1.45 ± 0.36), Mean Gradient (0.83 mmHg ± 0.29 mmHg), Peak Gradient (2.21 mmHg ± 0.82 mmHg), PHT (48.25 m/sec ± 11.13 m/sec), MVDT (151.40 m/sec ± 31.44 m/sec) , MVA (4.85 cm2 ± 1.12 cm2), MR Mild in 82 % patients ,TV Vel (0.61 m/sec ± 0.13 m/sec), RAP (est) (10 mmHg ± 0 mmHg), TR Vel (20.78 m/sec ± 5.62 m/sec), RSVP (est) (29.04 ± 4.54),TR Mild in 86 % Patients.PV Vel ( 0.72 m/sec ± 0.16 m/sec). Top 10 percentile parameters are follows RVDD 2.75 cm, LVED 4.79 cm, IVS 0.97 cm, LVEF 67.04 %, LVES 3.25 cm, LVPW 0.97 cm, LVOT Dia 2.08 cm, Ao Root 3.10 cm, LA Dia 3.59 cm AV Vel 1.29 m/sec , LVOT Vel 1.23 m/sec , Mean Gradient 3.68 mmHg, Peek Gradient 6.70 mmHG,AVA 3.21 cm2. E Vel 0.94 m/sec , A Vel 0.67 m/sec , E/A Ratio 1.91 , Mean Gradient 1.20 mmHg, Peak Gradient 3.26 mmHg, PHT 62.51 m/sec , MVDT 191.69 m/sec, MVA 6.29 cm2, TV Vel 0.78 m/sec, RAP (est) 10mmHg, TR Vel 27.98 m/sec, RSVP (est) 34.81,PV Vel 0.93 m/sec. Conclusion: POTS patients have normal echocardiographic parameters however even the top 10 percentile of these patients had smaller LVEDD. Similarly the internal dimensions of cardiac chambers does appear to be smaller though still within accepted normal parameters. Further studies should be taken to better define this subgroup.
Hepatomas in Mice on a Diet Containing Bentonite&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: J. Walter Wilson
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Hepatomas in Mice on a Diet Containing Bentonite Get access J. Walter Wilson J. Walter Wilson Arnold Biological Laboratory, Brown University, Providence, R. I. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 1, August 1953, Pages 65–75, https://doi.org/10.1093/jnci/14.1.65 Published: 01 August 1953 Article history Received: 29 December 1952 Published: 01 August 1953
Cutaneous Moniliasis: Topical Treatment with Amphotericin B Lotion
Authors: D M COHEN, M M NIERMAN, M GOLDIN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Admixture In Sickle Cell Disease Defined By Genome Wide Ancestry Informative Markers Varies By Geographic Region In The United States
Authors: Zhengyuan Wang, Lena Diaw, Michael Dizon, Marci Barr, Meghan Quinn, Dominique Diggs, Darlene Allen, Cassie Seamon, Anna Oguhebe, Deepika Darbari, Yingze Zhang, Mark T. Gladwin, Amy A. Hutchinson, Laurie Burdette, Carolyn Hoppe, James G. Taylor
Journal: Blood (2013)
Therapeutic Applications of Angiography
Authors: Christos A. Athanasoulis
Journal: New England Journal of Medicine (1980)

Methods to Increase Regional Blood FlowBlood flow to an organ or vascular bed may be increased with mechanical means, such as dilatation of a stenotic artery, recanalization of an occluded arterial segment, or removal of an embolus or thrombus, or with intraarterial infusion of vasodilatory drugs.Percutaneous Transluminal AngioplastyThe recent introduction by Grüntzig of a special balloon catheter for percutaneous transluminal angioplasty has revived interest in this country in a method introduced by Dotter in 1964.104 , 105 The principle is to dilate an area of hemodynamically important arterial stenosis or recanalize a short arterial occlusion by compressing the soft . . .
Bookcase
Authors: C. Martyn
Journal: BMJ (1998)

He was bigger even than I expected, well over six feet though then almost 80: a vast crag of a man, slow moving but upright, the famous shrapnel scar in his left cheek still deep after more than 50 years.

The occasion was one peculiar to the ancient Scottish universities: a rectorial installation. Malcolm Muggeridge had been our candidate. The founding father of the British Broadcasting Corporation was his guest. And—probably because I was a medical student and might therefore know what to do if he died—I had been detailed to look after Lord Reith.

He was solemn and uncommunicative, politely tolerant of my shepherding him through the ceremony and to his car afterwards. When he grunted his thanks I had a vague feeling that he was expecting me to stand to attention and salute. Duty done, I rejoined the team for the serious business of the day, the traditional wallow in University Union beer.

Almost 20 years later he cropped up again, at least in spirit. With a BBC script editor I was working in Edinburgh on a television drama series about the horrors and consolations of junior medical life. The oak table at which we sat bore a small brass plate to the effect that it had once served as the desk of one John Reith.

Our script probed the limits of the BBC’s then current concept of decency, and we knew it. If the spirit of Lord Reith objected to this desecration of his desk it failed to say so at the time. But Reithian values descended soon enough. Postproduction, our efforts evoked outrage from on high. Fifty minutes of expensive filming, including a fair amount of pubic hair, hit the cutting room floor. Sorry sir, point taken.

I thought of him again a couple of weeks ago. Invited to a BBC seminar, I arrived—very much the token Scot and something of a country mouse—in the council chamber of Broadcasting House. There were a lot of grey suits, and only one face I knew: Lord Reith glared down from a portrait dominating the room.

In the seminar his successors grappled honestly with the uncertainties of political change and technological revolution. I love the BBC, and dearly hope that it gets it right. But if it doesn’t may God save it from the wrath of Reith.

Could you write for “Soundings?”
The BMJ is holding a competition for new contributors to this column. Send one article (400 words, double spaced) plus outlines for a further three to: Soundings Competition, BMJ, BMA House, Tavistock Square, London WC1H 9JR by 8 January 1999. The winner will be asked to contribute regularly for at least six months, at a fee of £150 for each article. Overseas contributors are specially welcome.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1960)

COMMITTEE ON MATERNAL WELFARE*Post-Partum Hemorrhage and ShockTen years after her last baby, a forty-two-year-old gravida 5, para 4, presented hypertension, albuminuria and edema prenatally. The blood pressure, which was 180 systolic, 110 diastolic, at eight weeks, remained high despite restrictions on activity and salt, and the use of chlorothiazide. It rose to 210 systolic, 100 diastolic, at thirty-eight weeks. Urinalyses revealed traces of albumin throughout, and noticeable edema appeared during the last six weeks. The total weight gain was 9.1 kg. (20 pounds).Admitted two weeks from term with irregular contractions and a blood pressure of 180 systolic, . . .
Prognostic factors for women with ovarian germ cell tumors.
Authors: J I Mayordomo, L Paz-Ares, M T Diaz-Puente, P Lianes, M D Garcia-Prats, H Cortes-Funes
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.8.1737 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8040686 Prognostic factors for women with ovarian germ cell tumors. J I MayordomoxJ I MayordomoSearch for articles by this author , L Paz-AresxL Paz-AresSearch for articles by this author , M T Diaz-PuentexM T Diaz-PuenteSearch for articles by this author , P LianesxP LianesSearch for articles by this author , M D Garcia-PratsxM D Garcia-PratsSearch for articles by this author , H Cortes-FunesxH Cortes-FunesSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.8.1737 PDF "Prognostic factors for women with ovarian germ cell tumors.." Journal of Clinical Oncology, 12(8), pp. 1737–1738© 1994 by American Society of Clinical Oncology
QOS-57BEHAVIOR IN SURVIVORS OF PEDIATRIC MEDULLOBLASTOMA: THE IMPACT OF COGNITIVE FLEXIBILITY, INTELLIGENCE, AND NEGATIVE AFFECT
Authors: Nicole Law, Iska Moxon-Emre, Eric Bouffet, Michael D. Taylor, Ute Bartels, Nadia Scantlebury, Donald Mabbott
Journal: Neuro-Oncology (2016)
Abstract 13764: Development of in vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived From Human Induced Pluripotent Stem Cells
Authors: Maki Takeda, Shigeru Miyagawa, Satsuki Fukushima, Atsuhiro Saito, Emiko Ito, Ryohei Matsuura, Akima Harada, Noriko Oda, Yuto Amano, Michiya Matsusaki, Mitsuru Akashi
Journal: Circulation (2015)

Introduction: In vitro drug-induced cardiotoxicity assay is a critical step in drug discovery for clinical use. Use of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is promising f...
MB-25SUPPRESSION OF LEPTOMENINGEAL DISSEMINATION OF MEDULLOBLASTOMA BY PANOBINOSTAT, A HISTONE DEACETYLASE INHIBITOR
Authors: Ji Hoon Phi, Seung Ah Choi, Pil Ae Kwak, Ji Yeoun Lee, Kyu-Chang Wang, Do Won Hwang, Seung-Ki Kim
Journal: Neuro-Oncology (2016)
HG-68COMBINED ALTERATIONS IN MAPK PATHWAY GENES, CDKN2A/B AND ATRX CHARACTERIZE ANAPLASTIC PILOCYTIC ASTROCYTOMA
Authors: Annekathrin Kratz, Felix Sahm, Daniel Schrimpf, David T. Jones, David Reuß, Christian Kölsche, Kristin Huang, Annika K. Wefers, Volker Hovestadt, Dorothee Gramatzki, Jörg Felsberg, Arend Koch, Ulrich W. Thomale, Guido Reifenberger, Albert Becker, Volkmar Hans, Marco Prinz, Ori Staszewski, Till Acker, Hildegard Dohmen-Scheufler, Christian Hartmann, Wolf Mueller, Muin S. A. Tuffaha, Werner Paulus, Katharina Heß, Benjamin Brokinkel, Jens Schittenhelm, Camelia Monoranu, Almuth Friederike Keßler, Rolf Buslei, Martina Deckert, Christian Mawrin, Patricia Kohlhof, Ekkehard Hewer, Adriana Olar, Fausto Rodriguez, Caterina Giannini, Amulya A. NageswaraRao, Michael Weller, Ute Pohl, Sebastian Brandner, Stefan M. Pfister, Andreas von Deimling, David Capper
Journal: Neuro-Oncology (2016)

Introduction: Tumors with histological features of pilocytic astrocytoma but with increased mitotic activity and additional high grade features (i.e. microvascular proliferation, necrosis) have been designated anaplastic pilocytic astrocytomas (APA). Patients with such tumors are thought to have an [for full text, please go to the a.m. URL]