tbuckley/cabot-search huggingface dataset:
Abstract 4819: Assessing the environmental factors in two Ontario communities with diverging colorectal cancer incidence rates .
Authors: Jeavana Sritharan, Rishikesan Kamaleswaran, Ken McFarlan, Manon Lemonde, Clemon George, Otto Sanchez
Journal: Cancer Research (2013)

Abstract Colorectal cancer is the third most diagnosed cancer and second leading cause of cancer related deaths in Canada. As Ontario has the largest population in Canada, it also has great disparities in colorectal cancer incidence. The region of Timiskaming has the highest incidence for colorectal cancer, while the region of Peel has the lowest incidence for colorectal cancer in Ontario. There are no previously published studies regarding cancer or environmental risk factors performed in the Timiskaming region. The purpose of this study was to identify the dominant non-nutritional modifiable environmental risk factors in the region of Timiskaming compared to the reference region of Peel that may be associated with diverging colorectal cancer incidence rates. After reviewing the available published literature, a questionnaire assessment tool regarding environmental exposures was created. This questionnaire tool was created by combining standardized questionnaire tools available in the published literature that assessed environmental exposures. The questionnaire assessment tool was then utilized within a pilot study group followed by the Timiskaming and Peel participant communities. The tool assessed the exposures of tobacco smoking, alcohol use, pesticides/organochlorines, metal toxins, occupational exposures, and medical ionizing radiation. A total of 53 participants completed the questionnaire tool in Timiskaming, and a total of 61 participants completed the questionnaire tool in Peel. Findings indicate that there are dominant non-nutritional modifiable environmental risk factors in the region of Timiskaming that may be associated with colorectal cancer when compared to the region of Peel. The significant dominant environmental factors identified by Timiskaming participants were tobacco smoking, alcohol use, pesticides/organochlorines, and metal toxins. The findings also indicate that the Peel community may have important community health initiatives that can be used in the Timiskaming community to reduce the present colorectal cancer disparities. Following this study, it is imperative that recommendations are directed at a community level and relate to the assessment of potential non-nutritional modifiable environmental risk factors. While colorectal cancer disparities are evident, future research should help to understand the relationship between cancer disparities and environmental risk factors. Citation Format: Jeavana Sritharan, Rishikesan Kamaleswaran, Ken McFarlan, Manon Lemonde, Clemon George, Otto Sanchez. Assessing the environmental factors in two Ontario communities with diverging colorectal cancer incidence rates . [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4819. doi:10.1158/1538-7445.AM2013-4819
PROTEOMIC TIME COURSE IN EARLY REMODELING AFTER MYOCARDIAL ISCHEMIA/REPERFUSION
Authors: Aleksandra Binek, Rodrigo Fernandez-Jimenez, Inmaculada Jorge, Emilio Camafeita, Juan Antonio Lopez, Navratan Bagwan, Carlos Galán, Jaume Aguero, Antonio Molina-Iracheta, Valentin Fuster, Borja Ibanez, Jesús Vázquez
Journal: Journal of the American College of Cardiology (2016)
PWE-006 How often is Bowel Cancer Detected from a Positive 3RD Kit in the English Bcsp?
Authors: A Field, M Vogler, R F Logan
Journal: Gut (2013)

<h3>Introduction</h3> In the English Bowel Cancer Screening Programme (BCSP) subjects returning a weak positive kit (1–4 of the 6 windows positive) are invited to do a 2<sup>nd</sup> kit and if none of the windows are positive they are invited to complete a 3<sup>rd</sup> kit. If any windows are then positive subjects are referred for possible investigation; if no windows are positive subjects are discharged from that screening round. This testing algorithm has been criticised for making the screening process too prolonged thereby producing anxiety and drop-outs and the Scottish BCSP has abandoned asking for a 3<sup>rd</sup> kit on the grounds that the yield was negligible. <h3>Methods</h3> We have analysed the outcomes from the 3rd kits returned to the Eastern BCSP Hub from subjects invited for screening between 1 Jan 2011 and 31 March 2012. <h3>Results</h3> Over this period over 850,000 subjects aged 60–74 yrs were invited for screening. 4% (20,021) completed 3 kits and of these 16% (3192) had a positive 3rdkit and were referred for further investigation. Of those investigated (2830) 4.4% (125) were found to have bowel cancer compared with 17.8% (298) with cancer found after a single kit and 8.1% (483) with cancer found after completing 2 kits. A further 7% and 12% completing 3 kits were found to have high and intermediate risk adenomas. The mean time from selection for screening to obtaining a definitive result for those completing 3 kits was 63 days compared to 34 days for those completing a single kit (95% of all subjects returning kits) and 49 days for those completing 2 kits (1% of all subjects returning kits). <h3>Conclusion</h3> A significant number (14%,125/906) of bowel cancers are detected in those completing 3 kits but this is at the cost of having a screening episode prolonged to almost twice that for subjects obtaining a definitive result after one kit. The intended introduction of faecal immunochemical tests to replace guaiac faecal occult blood tests should allow the use of a simpler and shorter testing algorithm. <h3>Disclosure of Interest</h3> None Declared.
Abstract 2921: Antitumorigenic effects by ERβ in three different human colorectal cancer cell lines
Authors: Karin Edvardsson, Anders Strom, Jan-Ake Gustafsson, Cecilia Williams
Journal: Cancer Research (2010)

Abstract The estrogen receptor beta (ERβ) is the predominant ER in the human colonic epithelium. Levels of ERβ are reduced in colorectal cancer compared to normal colon tissue. In a previous study, we generated ERβ-expressing colon cancer cells and showed that ERβ inhibits proliferation as well as colon cancer xenograft growth, as a consequence of ERβ mediated inhibition of cell-cycle pathways. The present study was conducted to investigate genome wide changes by ERβ in three human colon cancer cell lines (SW480, HT29 and HCT116). They have very low or no levels of ERβ expression and were transduced with lentivirus containing an ERβ expression cassette. Microarray studies showed that ERβ regulated 623, 643 and 124 genes for SW480, HT29 and HCT116, respectively. Comparisons showed few genes in common for the three cell lines. However, over representation analysis showed that several themes, such as cell proliferation, cell communication and apoptosis were regulated in all of the cell lines. By comparing our results with those from a ChIP-on-Chip assay in breast cancer cells, we found that a considerable proportion of regulated genes had an ERβ binding site nearby or within the gene. Our preliminary conclusion is that ERβ appears to, at the gene expression level, have related anti-tumorigenic effects in different colon tumor cells, but different genes may be regulated in different cells types. Furthermore, the fact that several of the regulated genes possessed an ERβ DNA binding region nearby or within the gene indicates a direct regulation for many of these genes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2921.
Abstract 2778: Association between mammographic density and serum 25-hydroxyvitamin D levels
Authors: Katherine D. Crew, Julie Flom, Parisa Tehranifar, Mary Beth Terry
Journal: Cancer Research (2010)

Abstract Background: Previous studies have demonstrated an inverse association between vitamin D and risk of breast cancer. In addition, dietary vitamin D intake has been associated with lower mammographic density (MD), a strong intermediate marker of breast cancer risk. We examined the relationship between MD and serum 25-hydroxyvitamin D [25(OH)D], an integrated measure of vitamin D status from food, supplements, and sun exposure, in a multi-ethnic cohort of women undergoing screening mammography. Methods: Using a cross-sectional study design, 195 women without a history of breast cancer completed a routine screening mammogram, in-person interviews collecting data on demographics, lifestyle factors, and breast cancer risk factors, and donated a blood sample. We digitized mammograms and evaluated the proportion of dense area on cranial-caudal images using Cumulus software. Serum 25(OH)D was measured in batched, archived specimens by Diasorin radioimmunoassay. We used a multivariate linear regression model to investigate the association of percent density with serum 25(OH)D. We examined confounding by age, race/ethnicity, body mass index (BMI), season of blood draw, and breast cancer risk factors. Results: A total of 195 women enrolled, 116 donated a blood sample and were evaluable for analysis; median age: 49.9 years (range 40.0-60.9); white/African American/African Caribbean/Hispanic Caribbean: 26%/43%/19%/12%. The prevalence of vitamin D deficiency [25(OH)D &amp;lt;20 ng/ml] was 24% among whites, 52% in African Americans, 33% in African Caribbeans, and 43% in Hispanics (Chi-square p-value=.09). Age and BMI were inversely associated with MD (p&amp;lt;0.001). After adjusting for known confounders, we found no association between serum 25(OH)D and percent density. Discussion: In contrast to some previous reports, vitamin D does not appear to be related to MD in this multiethnic cohort. Vitamin D status, a potentially modifiable risk factor, may have a protective effect against breast cancer development which is not mediated by changes in breast density. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2778.
Intérêt de l'insufflation au CO2 pour la réalisation des cholangiopancréatografies rétrogrades endoscopiques (CPRE). Résultats préliminaires d'une étude prospective randomisée
Authors: F Fumex, C Lefort, J Fumex, I Mohammedi, V Vial, D Resende, B Napoléon
Journal: Endoscopy (2011)

L'insufflation de CO2 à la place de l'air pourrait améliorer le confort des patients lors des procédures endoscopiques. Son intérêt reste cependant controversé. Les résultats de la littérature concernant la CPRE sont limités et discordants. Le but de cette étude prospective randomisée était de comparer sur 100 patients la tolérance de la CPRE après insufflation d'air ou de CO2.
Abstract 5075: Genome-wide analysis of DNA copy number variations in osteosarcoma
Authors: Nalan Gokgoz, Jay S. Wunder, Irene L. Andrulis
Journal: Cancer Research (2012)

Abstract Objectives: Copy number variations (CNVs) such as deletions, amplifications and duplications across the whole genome may contribute to Osteosarcoma (OS) tumorigenesis. Detection of genomic regions containing these changes is extremely important for both the basic understanding of OS and its diagnosis. In this study we performed Whole Genome Genotyping (WGG) using high-density SNP arrays to detect CNVs in OS tumors and blood. A major advantage of this technology is the simultaneous detection of both allelic frequencies and CNVs. Methods: WGG analysis was performed using 35 high-grade intramedullary OS and 8 parosteal sarcoma tumor DNAs. 10 matching germline DNAs from blood were also included into the analysis. 250 nanograms of DNA were hybridized onto the Illumina 610 Quad BeadChips using the Infinium II WGG assay. The WGG data was analysed using Bead Studio and Partek software. Results: SNP array based Whole Genome Genotyping revealed a large number of chromosomal aberrations in OS. Preliminary analysis of 35 OS tumor DNAs showed high levels of recurrent amplification of 1p36, 3p12.1, 6q14, 12q13-15, 17p11.2, 20p12; and deletion of 3q26.31, 6p21, 6q16.3, 7q21, 7q35, 8q24.13, 9p21 and 17p13 regions. Parosteal tumor DNAs displayed a high level of amplification of the 12q13-15 amplicon. Amplification status of genes from 17p11.2 (PMP22, NCOR1, COPS3 and TOM1L2) and 12q14 (CDK4 and MDM2) was validated by Real-Time PCR. Some tumors exhibited whole chromosome arm deletions and/or duplications. Conclusions: OS tumors exhibit chromosomal alterations that can be detected using WGG. Comparison of normal and tumour DNAs from the same subjects can be used to identify CNV associated with OS development and progression. Current analyses include comparisons of CNV data and gene expression profiles of the same OS tumours to discover genes that may be biologically relevant targets in OS. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5075. doi:1538-7445.AM2012-5075
Trends in Cervical Cancer Rates in Norway
Authors: R. K. PETERS, B. E. HENDERSON
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Trends in Cervical Cancer Rates in Norway Get access RUTH K. PETERS, RUTH K. PETERS Department of Preventive Medicine, School of Medicine, University of Southern CaliforniaLos Angels, CA 90033 Search for other works by this author on: Oxford Academic PubMed Google Scholar BRIAN E. HENDERSON BRIAN E. HENDERSON Department of Preventive Medicine, School of Medicine, University of Southern CaliforniaLos Angels, CA 90033 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 4, 20 April 1988, Pages 288–289, https://doi.org/10.1093/jnci/80.4.288-a Published: 20 April 1988
THE ROLE OF GENETICS IN VENTRICULAR TACHYARRHYTHMIA RISK STRATIFICATION: PRIMARY RESULTS FROM THE DISCOVERY TRIAL
Authors: Heinrich Wieneke, Domenico Corrado, Jeff Lande, Javier Garcia Fernandez, Jesper Svendsen, Herve Le Marec, Juan Gabriel Martinez, Sebastian Spencker, Bernhard Strohmer, Lauri Toivonen, Winfried Siffert
Journal: Journal of the American College of Cardiology (2015)
Abstract 1708: Metabolic regulation of the ubiquitin+proteasome system.
Authors: James J. Driscoll, Sajjeev Jagannathan
Journal: Cancer Research (2013)

Abstract The ubiquitin+proteasome system (UPS) is a highly complex network that maintains protein homeostasis and cell viability through the highly regulated and selective turnover of targeted proteins. The proteasome is the major intracellular protease in eukaryotes and serves as the catalytic core of the UPS. The cytotoxic effect of proteasome inhibition has been translated therapeutically to dramatically improve the overall survival of patients diagnosed with the plasma cell malignancy multiple myeloma (MM). Bortezomib has emerged as the standard-of-care therapy for MM to catapult the UPS into a position of prominence in cancer biology and drug development but significant obstacles remain since many patients do not respond to bortezomib, clinical responses are not sustained and drug resistance inevitably emerges through unknown mechanisms. Gene profiling was performed as an unbiased approach to address the precise molecular events that promote bortezomib-resistance. Results indicated that effectors of energy metabolism were differentially expressed in cells resistant to bortezomib. Subunits of the cellular energy sensor AMP-activated protein kinase (AMPK) were expressed at lower levels in resistant cells relative to the parental cells. Real-time, cell-based metabolic measurements demonstrated that bortezomib rapidly and dramatically reduced tumor cell oxygen-consumption while bortezomib-resistant cells were less sensitive to metabolic deregulation. Genetic ablation of the AMPKα1/α2 encoding-genes also reduced the effect of bortezomib to promote autophagosome formation as well as bortezomib-induced cytotoxicity. Similarly, knockout of the AMPK-substrate and autophagy-initiating kinase ULK1 also reduced bortezomib-induced autophagosome formation and cell death. Proteasome inhibition promoted ULK-1 association with the autophagosome initiators ATG13, FIP200 and beclin-1. The AMPK activator AICAR further enhanced bortezomib-induced cytotoxicity in myeloma, lymphoma, leukemic and solid tumor cells. Proteasome inhibitors induce AMPK+ULK-mediated autophagosome formation that is coupled to apoptosis and can be exploited as a novel anti-cancer therapeutic strategy. Citation Format: James J. Driscoll, Sajjeev Jagannathan. Metabolic regulation of the ubiquitin+proteasome system. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1708. doi:10.1158/1538-7445.AM2013-1708
Imipramine treatment of methadone maintenance patients with affective disorder and illicit drug use
Authors: E V Nunes, F M Quitkin, R Brady, J W Stewart
Journal: American Journal of Psychiatry (1991)

Of 17 consecutive patients receiving methadone maintenance treatment who had primary or chronic depression, nine (53%) improved in both mood and drug abuse after imipramine treatment. This finding suggests a potential for helping such dual-diagnosis patients reduce drug abuse and associated risk for HIV. Further controlled trials are warranted.
Abstract 4261: Inhibition of Bmi-1 suppressed the tumorigenicity of oral cancer-derived ALDH1-positive cells
Authors: Chiou Shih-Hwa
Journal: Cancer Research (2010)

Abstract Bmi-1, a member of the Polycomb family of transcriptional repressors, is essential for maintaining the self-renewal abilities of adult stem cells. Bmi-1 has been demonstrated to play a role in tumorigenesis in head and neck squamous cell carcinomas (HNSCCs). A recent study has further suggested that ALDH1 may be considered to be a putative marker for HNSCC-derived cancer stem cells. However, the role that Bmi-1 plays in HNSCC-derived ALDH1-positive cells (HNSCC- ALDH1+) has yet to be determined. In this study, we demonstrated that HNSCC- ALDH1+ cells possess tumor initiating properties, are capable of self-renewal, and express higher levels of Bmi-1 as compared to HNSCC-ALDH1− cells. To further explore the functional role of Bmi-1 in HNSCC-ALDH1+ cells, we used a lentiviral vector expressing shRNA to knock down Bmi-1 expression (sh-Bmi-1) in HNSCC- ALDH1+ cells. Silencing of Bmi-1 significantly enhanced the sensitivity of HNSCC- ALDH1+ cells to chemoradiation and increased the degree of chemoradiation- mediated apoptosis that occurred. Importantly, knockdown of Bmi-1 increased the effectiveness of radiotherapy and led to the inhibition of tumor growth in nude mice transplanted with HNSCC-ALDH1+ cells. Kaplan-Meier survival analysis indicated that the mean survival rate of HNSCC-ALDH1+ tumor-bearing immunocompromised mice treated with radiotherapy was significantly improved by treatment with sh-Bmi-1 as well. In summary, these results suggest that Bmi-1 is a potential target for increasing the sensitivity of HNSCC cancer stem cells to chemoradiotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4261.
Aneurysm of the Distal Descending Thoracic Aorta Causing a Pulmonary Perfusion Defect
Authors: VALÉRIE LEVERT, VILMA DERBEKYAN, ABDULKAREEM ALKAHTANI, NOVALES DIAZ
Journal: Clinical Nuclear Medicine (2001)

LEVERT, VALÉRIE M.D.; DERBEKYAN, VILMA M.D.; ALKAHTANI, ABDULKAREEM M.D.; DIAZ, NOVALES M.D. Author Information
PTU-137 ‘Nutrient Sensing in the Human Gut: Investigation of the Co-Localization Rate Between Casr, T1R1 and GPR43 Receptors with Satiety Peptides in the Human Antrum, Terminal Ileum and Ascending Colon.’
Authors: V Galanakis, M Peiris, A L Blacksaw
Journal: Gut (2013)

<h3>Introduction</h3> Increasing evidence from animal studies show that apical nutrient sensing receptors, expressed in gut enteroendocrine cells, play a key role in the release of satiety peptides<sup>{1,2}</sup>. Early human studies indicate a similar expression pattern of these receptors and role in peptide release<sup>{3}</sup>. In this study the anatomical relationship between amino acid sensing (CaSR), carbohydrate sensing (T1R1), and short chain fatty acid sensing (GPR43) receptors and appetite regulating peptides GLP-1, PYY, 5-HT was investigated in the human gut. <h3>Methods</h3> Healthy full thickness human gut sections were incubated with primary and fluorescent secondary antibodies and they were viewed under the fluoroscopic microscope to investigate co-localization of the CaSR, T1R1 and GPR43 with the GLP1, PYY and 5HT. <h3>Results</h3> The co-localization rate between CaSR and PYY, GLP1 and 5HT was 0%, &lt; 1% and 43% in the antrum, 20%, 12% and 82% in the ileum and 26%, 14% and 91% in the colon, respectively. Co-localization of T1R1 and GLP1 was observed only in the antrum and the colon. GPR43 was not expressed. <h3>Conclusion</h3> CaSR is expressed at protein level and is colocalized with PYY, 5HT and GLP1 in the human antrum, terminal ileum and ascending colon. T1R1 expression at protein level is very limited in all the tested tissues. GPR43 expression was not observed. The results suggest that CaSR is linked to PYY, GLP1 and 5HT release in the human gut, with data being stronger for the 5HT release. <h3>Disclosure of Interest</h3> None Declared <h3>References</h3> Sternini, <i>et al.</i> 2008. Enteroendocrine cells: a site of ‘taste’ in gastro- intestinal chemosensing. Curr Opin Endocrinol Diabetes Obes 15(1): 73–78. Frenchet <i>et al.</i> 2000. The effects of intestinal infusion of long-chain fatty acids on food intake in humans. Gastroenterology 2000; 119: 943–8. Page <i>et al.</i> 2012. Peripheral neural targets in obesity. British Journal of Pharmacology, 1568-RC.R1.
99mTc-MDP SPECT/CT for Assessment of Condylar Hyperplasia
Authors: Thorsten Derlin, Jasmin D Busch, Christian R Habermann
Journal: Clinical Nuclear Medicine (2012)

We report a case of condylar hyperplasia diagnosed with 99mTc-MDP SPECT/CT. A 21-year-old woman with facial asymmetry was referred for assessment of condylar growth activity. SPECT/CT confirmed condylar hyperactivity, and simultaneous low-dose CT contributed to the diagnosis of hemimandibular hyperplasia. SPECT/CT may become a valuable tool for the diagnosis and comprehensive assessment of condylar hyperplasia, providing both functional and morphological information.
West Midlands GPs get new advice team
Authors: D. Carnall
Journal: BMJ (1995)

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