tbuckley/cabot-search huggingface dataset:
Brief treatment of emergency room patients with panic attacks
Authors: R P Swinson, C Soulios, B J Cox, K Kuch
Journal: American Journal of Psychiatry (1992)

Most research on treatment for panic disorder has involved chronic forms of the illness. To determine the efficacy of early intervention, the authors examined the effects of treatment for patients with panic attacks who were seen in the emergency room, which is the first point of contact with the health delivery system for many persons with panic attacks.The subjects were 33 patients with panic attacks seen in two emergency rooms. The presence of panic attacks was confirmed with a modified version of the Structured Clinical Interview for DSM-III-R; approximately 40% of the patients met the DSM-III-R criteria for panic disorder with agoraphobia. The patients were randomly assigned to groups receiving reassurance (N = 16) or exposure instruction (N = 17). Scores on the Fear Questionnaire agoraphobia subscale, Mobility Inventory, and Beck Depression Inventory and the frequency of panic attacks were determined at baseline, 3 months, and 6 months.The subjects who received exposure instruction significantly improved over the 6-month period on depression, avoidance, and panic frequency. The reassurance subjects did not improve on any measure and eventually reported more agoraphobic avoidance.These results suggest that early intervention with exposure instruction may reduce the long-term consequences of panic attacks. The exposure instruction was of value even though the subjects had relatively low levels of avoidance at the outset of the study.
Akathisia induced by amoxapine
Authors: D R Ross, J I Walker, J Peterson
Journal: American Journal of Psychiatry (1983)

Am J Psychiatry 1 40: 1 , January 1983 115 with a population of alcoholics known to have low platelet MAO at the time of alcohol abuse. Such a prospective study, however, would have to last at least as long as the abstinence of our subjects. Other approaches to determining the effect of alcohol on MAO activity, such as correlational analyses of length of alcohol abuse or the amount of alcohol consumed, may not be meaningful because a threshold effect of alcohol on MAO is likely, after which a longer time or greaten amount might not suppress MAO further.
SP0025 My Role as A Collaborative Partner in Scientific Initiatives
Authors: L. Andersen
Journal: Annals of the Rheumatic Diseases (2015)

Description of my experiences as a PRP and how these experiences have an influence on my role in scientific initiatives. What I expected my role to be and how it turned out to be. The worries I may have for not being able to live up to what I imagine the doctors expect to be my role in a EULAR project. I thought i was supposed to, not only being an expert in daily life with RA but also in all the technical and proffesional terms in the project I was in. Patint have different roles due to different lives-such as life experiences, education and course of disease. The role you have as a petint is always depending on what is in your "luggage". Key message: Always remember the patient perspective. <h3>Disclosure of Interest</h3> None declared
Effect of multiple time point sampling on the sensitivity of the dexamethasone suppression test
Authors: F C Goggans, W R Wilson, M S Gold, A L Pottash
Journal: American Journal of Psychiatry (1983)

Dexamethasone suppression test sensitivity in 188 patients was 61.6% when cortisol was measured at six time points and 48.5% when cortisol was measured twice. More patients had abnormal cortisol levels at 8:00 p.m. than at 4:00 p.m. or 10:00 p.m.
Abdominal tuberculosis in Britain.
Authors: B K Mandal, P F Schofield
Journal: BMJ (1977)

A series of fifteen patients with abdominal tuberculosis, managed personally by two clinicians over a five-year period, is presented. These fall into three broad groups: tuberculous peritonitis, gastrointestinal tuberculosis and tuberculous hepatitis. In more than half of the patients the chest radiographs were normal and three patients had negative tuberculin reactions. In emphasizing the fact that abdominal tuberculosis is not longer a rarity in Britain, attention is drawn to the many different ways in which the disease may present. One patient in the series, who presented as a possible case of cholera, had duodeno-colic fistula (only the third proven case in the literature) and two other patients presented with jaundice due to hepatic tuberculosis, again a rare form of abdominal tuberculosis.
Incense Burning during Pregnancy and Birth Weight and Head Circumference among Term Births: The Taiwan Birth Cohort Study
Authors: Le-Yu Chen, Christine Ho
Journal: Environmental Health Perspectives (2016)

Incense burning for rituals or religious purposes is an important tradition in many countries. However, incense smoke contains particulate matter and gas products such as carbon monoxide, sulfur, and nitrogen dioxide, which are potentially harmful to health.We analyzed the relationship between prenatal incense burning and birth weight and head circumference at birth using the Taiwan Birth Cohort Study. We also analyzed whether the associations varied by sex and along the distribution of birth outcomes.We performed ordinary least squares (OLS) and quantile regressions analysis on a sample of 15,773 term births (> 37 gestational weeks; 8,216 boys and 7,557 girls) in Taiwan in 2005. The associations were estimated separately for boys and girls as well as for the population as a whole. We controlled extensively for factors that may be correlated with incense burning and birth weight and head circumference, such as parental religion, demographics, and health characteristics, as well as pregnancy-related variables.Findings from fully adjusted OLS regressions indicated that exposure to incense was associated with lower birth weight in boys (-18 g; 95% CI: -36, -0.94) but not girls (1 g; 95% CI: -17, 19; interaction p-value = 0.31). Associations with head circumference were negative for boys (-0.95 mm; 95% CI: -1.8, -0.16) and girls (-0.71 mm; 95% CI: -1.5, 0.11; interaction p-values = 0.73). Quantile regression results suggested that the negative associations were larger among the lower quantiles of birth outcomes.OLS regressions showed that prenatal incense burning was associated with lower birth weight for boys and smaller head circumference for boys and girls. The associations were more pronounced among the lower quantiles of birth outcomes. Further research is necessary to confirm whether incense burning has differential effects by sex.Chen LY, Ho C. 2016. Incense burning during pregnancy and birth weight and head circumference among term births: The Taiwan Birth Cohort Study. Environ Health Perspect 124:1487-1492; http://dx.doi.org/10.1289/ehp.1509922.
PWE-426 Hepatology training in the uk – results from the bsg training survey 2014
Authors: M Corrigan, D Alzoubaidi
Journal: Gut (2015)

<h3>Introduction</h3> Issues around hepatology service delivery and training in the UK have been highlighted by the recent Lancet Commission.<sup>1</sup>Currently, the majority of liver services are delivered by gastroenterologists with &lt;6 months of hepatology. Increased numbers of specialists with advanced training are required to tackle the increasing burden of liver disease. Whilst guidelines exist to define minimum training requirements and competencies for all trainees,<sup>2</sup>training opportunities are variable. <h3>Method</h3> The 2014 trainee survey was sent to all UK trainees. 263/806 (32.6%) responded. Within the hepatology section of the survey, respondents were asked about future career plans, satisfaction with training, training opportunities and self assessed competence. <h3>Results</h3> Subspecialism: 8% of trainees plan to be a subspecialist hepatologist and 6% an academic hepatologist which is lower than those planning a career in general gastroenterology (16%), advanced endoscopy (12%) and IBD (10%). Overall experience: 68% of respondents rated themselves as either satisfied/very satisfied with their hepatology training. This is lower (p &lt; 0.01) than overall gastroenterology training (82.9%), basic endoscopy (79.9%) and IBD (79.2%). Barriers to training: 25.3% of trainees who wished to undertake formal hepatology training identified a barrier to accessing this. The main barriers were lack of local training opportunities and not wishing to move region to access hepatology training. Opportunities: All trainees should have at least 12 months in a level 2 or 3 centre.<sup>2</sup>However of current senior trainees (ST6+) less than 70% reported spending 6 months or more in at least one of these centres. Self reported competence of senior trainees to act as a consultant in a district general hospital found that 50% felt they were not competent in post transplant, viral and autoimmune liver disease and 30% felt they were not competent managing complications of portal hypertension including variceal bleeding. <h3>Conclusion</h3> The results confirm variability in hepatology training. This exists not only in access to advanced training but also core training competencies. All deaneries should aim to organise training rotations to maximise the opportunities especially in the deaneries which do not contain a level 3 centre. Early exposure of all trainees to hepatology units and clinics may allow better understanding of training pathways and early career planning. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Williams R, Aspinall R, Bellis M, Camps-Walsh G, Cramp M, Dhawan A, <i>et al</i>. Addressing liver disease in the UK: a blueprint for attaining excellence in healthcare and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity and viral hepatitis. Lancet 2014;384(9958):1953–1997 BSG Liver Section Training information 2014. http://www.bsg.org.uk/sections/liver-training/index.html
Total body irradiation and high-dose etoposide: a new preparatory regimen for bone marrow transplantation in patients with advanced hematologic malignancies [published erratum appears in Blood 1987 Jun;69(6):1789]
Authors: KG Blume, SJ Forman, MR O'Donnell, JH Doroshow, RA Krance, AP Nademanee, DS Snyder, GM Schmidt, JL Fahey, GE Metter
Journal: Blood (1987)
Effect of anticonvulsants on plasma haloperidol and thioridazine levels
Authors: M Linnoila, M Viukari, K Vaisanen, J Auvinen
Journal: American Journal of Psychiatry (1980)

Patients who had therapeutic plasma levels of phenobarbital and/or diphenylhydantoin had significantly lower plasma levels of haloperidol and mesoridazine, the active metabolite of thioridazine, than patients who did not receive anticonvulsants. Plasma thioridazine levels per se were not affected by concomitant anticonvulsant treatment. Biperiden, an antimuscarinic, antiparkinsonian agent, did not affect the plasma levels of these three neuroleptics.
Toxic reactions to the combination of monoamine oxidase inhibitors and tryptophan
Authors: H G Pope, J M Jonas, J I Hudson, M P Kafka
Journal: American Journal of Psychiatry (1985)

The combination of monoamine oxidase inhibitors and tryptophan--a recognized antidepressant regimen--has been reported to cause behavioral or neurologic toxicity. The authors present eight cases of delirious syndromes apparently attributable to this combination of agents.
The usefulness of Pap smear screening in ambulatory women over age 65
Authors: S. Waheed, T. Linthacum
Journal: Journal of Clinical Oncology (2005)

8212 Background: A cancer screening program in Mexico Missouri for women over the age of 40 and men over the age of 50, provides cancer screening, detection, education, and prevention. Conventional and liquid based Pap smears are offered to all ambulatory women. Statistics has shown one-fourth of all invasive cervical cancers occur in women over the age of 65. Thirty-six percent of women seen at this clinic are over 65. The objective for this study was to evaluate the usefulness of the Pap smear screening in ambulatory women over age 65. Methods: A retrospective 4-year analysis of Pap smear results were reviewed for the 2000–2003 years. During this study period, 9282 women were screened for cervical cancer with either the conventional or liquid based Pap smear, and 3355 of these women were over the age of 65. The age range for this older population was 65 to 85. AS-CUS to invasive cancer was the criteria used for classification of abnormal Pap smear. Results: During the years 2000 to 2003 thirty-six percent of the women seen at this clinic were over age 65. Twenty-eight of the 3355 Pap smears collected on this elderly population were abnormal and one of these was an endometrial carcinoma. Results found. 83% of pap smears on ambulatory women over 65 to be abnormal Conclusions: Screening programs are an excellent way to prevent and detect early cancers. Elderly women often view the Pap smear as synonomous with the pelvic exam. Pathological conditions related to gynecological health may be missed in this elderly population if annual exams are not performed. It is the experience of this clinic that continuing Pap smear screening in ambulatory women over age 65 to be useful. A serious discussion between clinician and patient should ensue before discontinuing Pap smears in the elderly. No significant financial relationships to disclose.
Successful Long-Term Phenotypic Correction Of Hemophilia A Mice By Engineering Functional Factor VIII Delivery System In Vivo Using Autologous Endothelial Cell Sheets
Authors: Hideto Matsui, Kohei Tatsumi, Kazuo Ohashi, Midori Shima, Mitsuhiko Sugimoto, Teruo Okano
Journal: Blood (2013)
Utility of a stent pusher catheter as a “mini-overtube” in the endoscopic management of post-liver transplant biliary strictures
Authors: G. Pereira, Juan Gutierrez, Marco D’Assuncao, Lucia Fry, Klaus Mönkemüller
Journal: Endoscopy (2015)

Biliary strictures and biliary leaks are the most common forms of post-transplant biliary complication [1] [2] [3]. These are thought to be due to multiple factors including ischemia, ischemia – reperfusion injuries, cytomegalovirus infection, and surgical techniques [2]. Endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic cholangiography, and surgery are the primary approaches used in addressing strictures, with ERCP being the gold standard as a diagnostic and therapeutic tool with the use of balloon dilations and placement of multiple parallel plastic stents [1] [2] [3]. However, some strictures have proven to be technically challenging or untreatable, mandating the use of percutaneous transhepatic cholangiographic drainage or even surgical hepaticojejunostomy. Herein we report a new method to deliver two wires above an impassable and severe anastomotic stricture by utilizing the pusher catheter as a "mini-overtube."
Abstract 592: Prognostic index system based on 20 genes for predicting recurrence of non-muscle invasive bladder cancer
Authors: Jong Hwan Kim, Seon-Kyu Kim, Seok-Joong Yun, Wun-Jae Kim, Seon-Young Kim
Journal: Cancer Research (2015)

Abstract Backgrounds There is a crucial need for practical molecular markers of bladder cancer recurrence, despite several molecular signatures for the bladder cancer outcomes have been numerously investigated. Here, we aim to identify a molecular signature consisting of small number of genes to predict disease recurrence in non-muscle invasive bladder cancer (NMIBC) and to assess its usefulness as a practical indicator. Methods Trascriptomic profiling was performed using gene expression data from 103 primary NMIBC specimens (Korean cohort) to identify a signature associated with disease recurrence. The prognostic value of the signature was validated in an independent cohort (European cohort, n = 302). Time-dependent receiver operating characteristic (ROC) curves of recurrence using the nearest neighbour estimation method with a cut-off value of 36 months were used to identify a small number of genes that strongly retain prognostic value. A prognostic index (PI) based on the expression data of 20 genes was developed in the Korean cohort and validated in the European cohort. The association between the 20-gene-based PI method and prognosis of NMIBC patients was assessed using Kaplan-Meier plot, the log-rank test, Cox proportional hazards model, and leave-one-out cross validation methods. Results The determination of gene expression patterns by transcriptome data analysis identified 822 genes associated with disease recurrence. Of the 822 genes, 20 genes which are highly associated with recurrence free survival were detected by time-dependent ROC curves. The PI was developed by using Cox coefficient values of 20 genes in the Korean cohort and its robustness was validated in the European cohort (log-rank test, P &amp;lt; 0.001). The PI was shown to be an independent risk factor by a multivariate analysis and subset stratification according to stage and (hazard ratio = 6.082, 95% confidence interval = 3.280 to 11.279, P &amp;lt; 0.001). The subset analysis also revealed that the PI could identify patients who would benefit from intravesical therapy. Finally, gene network analyses and experimental assays indicated that, among the 20 genes, CA9, ARTS-1 and FGF11 could be important mediators for NMIBC recurrence. Conclusions The PI system based on 20 genes illustrates a novel diagnostic tool to identify NMIBC patients that have a high risk of recurrence. Citation Format: Jong Hwan Kim, Seon-Kyu Kim, Seok-Joong Yun, Wun-Jae Kim, Seon-Young Kim. Prognostic index system based on 20 genes for predicting recurrence of non-muscle invasive bladder cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 592. doi:10.1158/1538-7445.AM2015-592
Low-grade endotoxemia, gut permeability and platelet activation in community-acquired pneumonia
Authors: Roberto Cangemi, Pasquale Pignatelli, Roberto Carnevale, Simona Bartimoccia, Cristina Nocella, Marco Falcone, Gloria Taliani, Francesco Violi, Simona Battaglia, Giuliano Bertazzoni, Elisa Biliotti, Cinzia Myriam Calabrese, Marco Casciaro, Maurizio De Angelis, Paolo De Marzio, Rozenn Esvan, Lucia Fazi, Domenico Ferro, Lucia Fontanelli Sulekova, Cristiana Franchi, Laura Giordo, Stefania Grieco, Elisa Manzini, Sergio Morelli, Paolo Palange, Daniele Pastori, Marco Rivano Capparuccia, Giulio Francesco Romiti, Elisabetta Rossi, Eleonora Ruscio, Alessandro Russo, Maria Gabriella Scarpellini, Stefano Trapè, Filippo Toriello
Journal: Journal of Infection (2016)
Baclofen-induced growth hormone release in major depression: relationship to dexamethasone suppression test result
Authors: K O'Flynn, T G Dinan
Journal: American Journal of Psychiatry (1993)

Fifteen patients with DSM-III-R major depression and 15 matched comparison subjects underwent baclofen-induced growth hormone (GH) release and the dexamethasone suppression test (DST). The GH responses of the patients were significantly blunted, especially those of the patients who were DST nonsuppressors. These findings may indicate lower than normal responsivity of type B gamma-aminobutyric acid (GABA-B) receptors in depression and a relationship between GABA-B receptor abnormality and dysfunction of the hypothalamic-pituitary-adrenal axis.
Safety and efficacy of eltrombopag (epag) versus placebo (pbo) for the treatment (tx) of chemotherapy-induced thrombocytopenia (CIT) in patients with solid tumors receiving gemcitabine (gem)-based chemotherapy (ctx): A phase I study.
Authors: Eric S. Winer, Howard Safran, Boguslawa Karaszewska, Donald A. Richards, Lee Hartner, Frederic Forget, Rodryg Ramlau, Kirushna Kumar, Bhabita Mayer, Brendan Mark Johnson, Conrad A. Messam, Yasser Mostafa Mostafa Kamel
Journal: Journal of Clinical Oncology (2012)

9117 Background: There are limited tx options for CIT. Epag, an oral, small molecule, thrombopoietin-receptor agonist that increases platelet (plt) production, is being explored for tx of CIT. Methods: This was the Ph I portion of a Ph I/II, blinded, pbo-controlled multicenter study in adults with solid tumors and baseline plts ≤300,000µL, who received up to 6 cycles of gem (1000-1250 mg/m 2 IV) as monotherapy on Days 1, 8, and 15 Q28 days or Days 1 and 8 Q21 days in combination with cisplatin (50-80 mg/m 2 IV Day 1 or divided 1 and 8) or carboplatin (AUC 4-7 IV Day 1). Patients received ctx alone for Cycle 1 and ctx plus epag or matching pbo (randomized 3:1) daily on Days -5 to -1 and 2 to 6 for subsequent cycles. Epag or pbo was interrupted for plts ≥400,000/µL. Results: 33 patients were randomized; 26 received epag or pbo (Table). Data review with an external, independent physician found no safety concerns, and there were sufficient plt increases with a dose of 100 mg epag vs pbo. No dose-limiting toxicities were reported for epag but 1 for pbo. Most AEs were grade 1 or 2. The most common AE in combined epag- and combined pbo-treated groups was neutropenia. Conclusions: Epag was well-tolerated and improved plt counts. Based on these encouraging Ph I results, Ph II using 100 mg epag in thrombocytopenic patients is planned. [Table: see text]
Probably benign findings, BIRADS category 3 (MR-Bi3), on magnetic resonance imaging of the breast (BrMR): Is repeated MRI an alternative to biopsy?
Authors: M. J. Janicek, V. M. Camaya
Journal: Journal of Clinical Oncology (2011)

21 Background: The shift from the use of BrMR for confirmation of known abnormality to the screening mode in problematic breast is associated with higher frequency of probably benign findings. Some of them still require biopsy, with or without close BrMR follow up (f/u), some may remain on observation only. Our pilot study analyzed clinical outcomes of MR-Bi3 pts and added value of close BrMR f/u. Proportion of MR-Bi3, some after “second look ultrasound” (2ndUS) with or without biopsy could be used among other monitors of BrMR practices. Methods: We reviewed BIRAD categories assigned to all 743 BrMRs done in period of year 2007 in our specialized breast imaging practice with dedicated BrMR (Aurora) system and full complement of diagnostic and interventional modalities. Frequency of MR-Bi3 and studies resulting in MR-Bi3 or biopsies after 2ndUS were analyzed. With benefit of 3 year clinical data, the outcome of patients on such short term f/u schedule was reviewed. Results: MR-Bi3 was assigned to 40 (5.4%) of our BrMRs on the initial evaluation, all of them yielded benign findings on follow up. Additional 26.2% of our studies required 2ndUS. After 2ndUS, 40% of these pts were converted to Bi4+5, continued with image guided biopsy with cancer detected in 35% of those. Remaining 60% of 2ndUS yielded “probably benign findings”, MR-Bi3, which means that total of 21.6% of our BrMRs remained on close f/u schedule with MRI. There were no additional delayed findings of malignancy in this group. Single additional BrMR was sufficient to confirm benign findings only in 47% of cases, 24% of patients required multiple BrMRs at 6 month intervals, remaining patients were followed by other modalities. Conclusions: Utilization of MR-Bi3 category reflects readers' confidence avoiding or justifying biopsies for border line findings. Targeted use of 2ndUS helps to identify patients who benefit from biopsy rather than close f/u. Proportion of repeated Bi3 and outcome of Bi3 could become valuable QA indices for monitoring of BrMR practices. Only in small proportion of cases, the use of Bi3 was not contributory, particularly in case of repeated BrMRs for the same abnormality.