tbuckley/cabot-search huggingface dataset:
PRESENILE PSYCHOSIS
Authors: PHILLIP POLATIN, PAUL H. HOCH, WILLIAM A. HORWITZ, LEON ROIZIN
Journal: American Journal of Psychiatry (1948)

Two cases of Pick's disease are presented in which brain biopsy studies were made. The clinical, differential diagnostic, and neuropathological aspects of these cases are discussed. This long neglected and poorly understood clinical entity—the presenile psychosis —is now receiving the close attention and careful scrutiny of more progressive neuropathologists and biochemists. The emphasis is no longer on changes in morphology but rather on the alterations occurring in the metabolism of brain tissue. With newer methods and finer techniques we can look forward to a better understanding of previously obscure neuropsychiatric disorders.
A national measles epidemic in Switzerland in 1997 : consequences for the elimination of measles by the year 2007
Authors: W J Paget, H Zimmermann, H Vorkauf
Journal: Eurosurveillance (2000)

Clinical cases of measles have been reported to the Swiss Sentinel Surveillance Network (Sentinella) since June 1986 and measles infections have been monitored by the national laboratory notification system since January 1988. These two surveillance syste
Abstract B1-58: Computational modeling provides new insights into KRAS mutant-specific responses to targeted therapy
Authors: Edward C. Stites
Journal: Cancer Research (2015)

Abstract Emerging data suggest different activating Ras mutants may have different biological behaviors. The most striking example may be in colon cancer, where activating KRAS mutations generally indicate a lack of benefit to treatment with cetuximab, with the activating KRAS G13D mutation an apparent exception. It is unclear why patients with KRAS G13D would respond to cetuximab; KRAS G13D shares the same general biochemical defects as the other oncogenic KRAS mutants. Here, a previously developed mathematical model of the biochemical reactions that regulate Ras signaling is used to investigate this problem. The purpose of the analysis is to determine whether known mechanisms of Ras signaling allow similar, but different, Ras mutants to respond differently to the same inhibitor, and to determine if the known biochemical properties of the G13D Ras mutant are consistent with increased sensitivity to upstream inhibition. Computational analysis of the mathematical model finds that differential response to upstream inhibition between different Ras mutants is indeed consistent with known mechanisms of Ras biology. Moreover, modeling demonstrates that the subtle biochemical differences between the responsive G13D mutant and the non-responsive G12D and G12V mutants are sufficient to explain the different responses to cetuximab. Simulations further identify differences in wild-type Ras signaling as the key difference between the mutants. The analysis suggests the elevated Km for the Ras GAP reaction on the G13D mutant is the biochemical property that most contributes to differences in wild-type Ras signaling. The identification of a single parameter that influences sensitivity to a targeted therapy is significant in that it suggests an approach to evaluate other, less common, Ras mutations for their anticipated response to cetuximab. Note: This abstract was not presented at the conference. Citation Format: Edward C. Stites. Computational modeling provides new insights into KRAS mutant-specific responses to targeted therapy. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B1-58.
Minihepcidin peptides as disease modifiers in mice affected by β-thalassemia and polycythemia vera
Authors: Carla Casu, Paraskevi Rea Oikonomidou, Huiyong Chen, Vijay Nandi, Yelena Ginzburg, Princy Prasad, Robert E. Fleming, Yatrik M. Shah, Erika V. Valore, Elizabeta Nemeth, Tomas Ganz, Brian MacDonald, Stefano Rivella
Journal: Blood (2016)
Pediatric Outcome after Maternal Cancer Diagnosed during Pregnancy
Authors: Tineke Vandenbroucke, Kristel Van Calsteren, Frédéric Amant
Journal: New England Journal of Medicine (2016)

1. Skou ST, Roos EM, Laursen MB, et al. A randomized, controlled trial of total knee replacement. N Engl J Med 2015; 373: 1597-606. 2. Kim J, Nelson CL, Lotke PA. Stiffness after total knee arthroplasty: prevalence of the complication and outcomes of revision. J Bone Joint Surg Am 2004; 86-A: 1479-84. 3. Lewis CG, Inneh IA, Schutzer SF, Grady-Benson J. Evaluation of the first-generation AAOS clinical guidelines on the prophylaxis of venous thromboembolic events in patients undergoing total joint arthroplasty: experience with 3289 patients from a single institution. J Bone Joint Surg Am 2014; 96: 1327-32.
Myocardial Arteriovenous Differences of Individual Free Fatty Acids in Healthy Human Individuals
Authors: A CARLSTEN, B HALLGREN, R JAGENBURG, A SVANBORG, L WERKOE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Above-knee amputations in psychiatric inpatients
Authors: D E Tomaszek, J A Buckwalter
Journal: American Journal of Psychiatry (1983)

Data on 121 primary above-knee amputations and 12 stump revisions performed on a population of nonambulatory elderly psychiatric inpatients showed that the overall morbidity and mortality rates compared favorably with those in previously published reports on other groups of patients who received the same type of amputations, despite the precarious health of the psychiatric patients. By use of spinal anesthesia; meticulous attention to the prevention, early detection, and prompt treatment of wound complications; and identification of patients at high risk, this often desperately needed operation can be performed with good results.
Immunological aspects of cancer.
Authors: R Penny
Journal: BMJ (1970)

Immunology occupies a central role in the area of cancer, both in research and clinical practice. This article first reviews normal immunity and describes the interaction of the cancer cell with cellular and humoral immune mechanisms. Such mechanisms play a considerable role in the emergence, proliferation, metastases, regression and recurrence of tumours. Immunological investigations are applicable to the diagnosis of some forms of cancer, especially leukaemias, lymphomas and myelomas as well as analysing the immune status of patients suffering from cancer, which give significant guidelines with respect to prognosis. Manipulation of immune response in the form of immunotherapy is emerging as an important area in cancer therapy.
Is Not Age, But Comorbidities. Allogeneic Hematopoietic Stem Cell Transplantation In Patients Older Than 50 Years In Argentina
Authors: Mariano Berro, Juan Garcia, Ana Basquiera, Maria Marta Rivas, Maria Cecilia Foncuberta, Ruben Burgos, Gregorio Jaimovich, Vera Milovic, Juliana Martinez Rolon, Guillermina Remaggi, Jorge Arbelbide, Jorge H Milone, Sebastian Yantorno, Gustavo Jarchum, Maria Sol Jarchum, G Caeiro, Gustavo Daniel Kusminsky
Journal: Blood (2013)
Circulating let‐7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C
Authors: Kentaro Matsuura, Valeria De Giorgi, Cathy Schechterly, Richard Y. Wang, Patrizia Farci, Yasuhito Tanaka, Harvey J. Alter
Journal: Hepatology (2016)

The goal of this study was to determine whether an association exists between circulating microRNA (miRNA) levels and disease progression in chronic hepatitis C (CHC), whether plasma or extracellular vesicles (EVs) were optimal for miRNA measurement and their correlation with hepatic miRNA expression, and the mechanistic plausibility of this association. We studied 130 CHC patients prospectively followed over several decades. A comprehensive miRNA profile in plasma using microarray with 2578 probe sets showed 323 miRNAs differentially expressed between healthy individuals and CHC patients, but only six that distinguished patients with mild versus severe chronic hepatitis. Eventually, let‐7a/7c/7d‐5p and miR‐122‐5p were identified as candidate predictors of disease progression. Cross‐sectional analyses at the time of initial liver biopsy showed that reduced levels of let‐7a/7c/7d‐5p (let‐7s) in plasma were correlated with advanced histological hepatic fibrosis stage and other fibrotic markers, whereas miR‐122‐5p levels in plasma were positively correlated with inflammatory activity, but not fibrosis. Measuring let‐7s levels in EVs was not superior to intact plasma for discriminating significant hepatic fibrosis. Longitudinal analyses in 60 patients with paired liver biopsies showed that let‐7s levels in plasma markedly declined over time in parallel with fibrosis progression. However, circulating let‐7s levels did not parallel those in the liver. Conclusion: Of all miRNAs screened, the let‐7 family showed the best correlation with hepatic fibrosis in CHC. A single determination of let‐7s levels in plasma did not have superior predictive value for significant hepatic fibrosis compared with that of fibrosis‐4 index, but the rate of let‐7s decline in paired longitudinal samples correlated well with fibrosis progression. Pathway analysis suggested that low levels of let‐7 may influence hepatic fibrogenesis through activation of transforming growth factor β signaling in hepatic stellate cells. (H epatology 2016;64:732‐745)
Royal London Ophthalmic Hospital
Authors: J. W. Hulke
Journal: BMJ (1866)

ENUCLEATION of the eyeball-that is, its removal by dissecting it out of its capsular fascia-was proposed in 1841 by O'Ferral and Bennett, nearly at the same time, and independently, as a comparatively safe and simple substitute, in certain cases, for the method of extirpation then commonly practised.In this proceeding, after division of the outer and occa- sionally also of the inner commissure, for the purpose of gaining space, the eyeball was transfixed by a thread or hook, which served to pull it forcibly for-
DHEA and Testosterone in the Elderly
Authors: Mitsuko Yasuda, Shigeo Horie
Journal: New England Journal of Medicine (2007)

To the Editor: In their report on the effects of dehydroepiandrosterone (DHEA) and testosterone when used as antiaging supplements, Nair et al. (Oct. 19 issue)1 conclude that low-dose testosterone replacement in elderly men has no “physiologically relevant beneficial effects on body composition, physical performance, [or] insulin sensitivity.” However, this conclusion is premature, since the testosterone replacement administered failed to achieve physiologic testosterone levels throughout the study period (Fig. 2 of the article). Moreover, despite the marginal increase in testosterone levels achieved, improvements in fat-free mass, fasting insulin levels, and bone mineral density were observed. Other studies of testosterone replacement, including those cited to support the authors’ conclusions,2 have shown a decrease in fat mass (12.5%) and an increase in lean mass (4%) when physiologic testosterone levels are achieved in elderly men. Studies of standard doses of testosterone in the treatment of testicular failure3 have shown additional positive effects on muscle strength, physical performance,4 and bone mineral density.5 Large, long-term trials are clearly needed to assess the risks and benefits of testosterone replacement in elderly men, and caution should be exercised regarding the treatment of andropause in men. However, the serum testosterone level achieved should be within the normal range to assess the effect on outcome measures adequately.
In large-vessel ischemic stroke, adding endovascular thrombectomy to usual care reduced 90-day disability
Authors: Dennis G. Maki
Journal: Annals of Internal Medicine (2016)

Source Citation Goyal M, Menon BK, van Zwam WH, et al; HERMES collaborators. Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials. Lancet. 2016;Feb 18. Epub ahead of print. 26898852
More is better but ... how is best: are milligrams over hours better than grams over minutes? The case of gemcitabine.
Authors: C F Pollera
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.5.2172 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9164234 More is better but ... how is best: are milligrams over hours better than grams over minutes? The case of gemcitabine. C F PolleraxC F PolleraSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.5.2172 First Page PDF © 1997 by American Society of Clinical Oncology
Abstract B17: Role of Sall2 transcription factor under genotoxic stress: A transcriptomic approach
Authors: Carlos A. Farkas, Francisco Fuentes, Boris Rebolledo, Kateryna Makova, Anton Nekrutenko, Ariel Castro, Roxana Pincheira
Journal: Cancer Research (2016)

Abstract The induction of genotoxic stress by chemotherapy is one of the first line treatments to eliminate neoplastic cells through apoptosis or programmed cell death. Our laboratory has characterized the Sall2 transcription factor, conserved among vertebrates, as a stress-response molecule, and demonstrated both in vitro and in vivo its requirement in the cell death-response caused by genotoxic stress. Few transcriptional targets of Sall2 are known, thus, additional targets most likely remain to be identified. We isolated mouse embryonic fibroblasts (MEFs) from a murine model deficient in Sall2 and from its normal counterpart, and use them to characterize the Sall2-dependent transcriptional response upon genotoxic stress using RNA-seq experiments. Under control conditions we identified ninety-six Sall2-dependent genes involved in immune system, inflammation, cell adhesion and the response to wounding. Under genotoxic stress one hundred twenty six genes were differentially expressed and dependent on Sall2, these genes are mainly involved in immunity, development and cell-cycle regulation. Finally, we performed validation of the analysis using qPCR. With this experimental outline, we are expecting to gain insights on how Sall2 contributes to the transcriptional program under normal and genotoxic stress-induced conditions. Citation Format: Carlos A. Farkas, Francisco Fuentes, Boris Rebolledo, Kateryna Makova, Anton Nekrutenko, Ariel Castro, Roxana Pincheira. Role of Sall2 transcription factor under genotoxic stress: A transcriptomic approach. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr B17.
Abstract 10962: Long-term Clinical Impact of Cardiac Arrest in Patients With First Onset Acute ST-segment Elevation Myocardial Infarction
Authors: Ki Hong Lee, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Hyung Wook Park, Sung Soo Kim, Young Wook Jeong, Si Hyun Rhew, Kamir Investigators
Journal: Circulation (2013)

Background: Cardiac arrest complicating acute ST elevation myocardial infarction (STEMI) is known to be associated with increased in-hospital mortality. However, little is known about long-term out...
Long-Term Follow-up of a Randomized Study Comparing Cyclophosphamide and Total Body Irradiation With Busulfan and Cyclophosphamide for Patients Receiving Allogeneic Marrow Transplants During Chronic Phase of Chronic Myeloid Leukemia
Authors: R.A. Clift, J. Radich, F.R. Appelbaum, P. Martin, M.E.D. Flowers, H.J. Deeg, R. Storb, E.D. Thomas
Journal: Blood (1999)
The advantages of circular stapling instrument compared with Albert-Lembert suture for anastomosis of Billroth I gastrectomy for gastric cancer
Authors: H. Imamura, H. Furukawa, M. Tatsuta, T. Kishimoto, K. Yamamoto, K. Yamamoto, R. Ohshiro
Journal: Journal of Clinical Oncology (2006)

14104 Background: In Japan, reconstruction with Billroth I using Albert-Lembert suture had been usually performed in distal gastrectomy for gastric cancer. However stapling instruments have within recent years gained wide acceptance not only in total gastrectomy but also in distal gastrectomy. We have introduced circular stapling instrument for anastomosis reconstructed with Billroth I since June 2001. Methods: 111 and 222 patients with gastric cancer underwent distal gastrectomy reconstructed with Billroth I using Albert-Lembert suture from June 1999 to May 2001 (Group A) and using circular stapling instrument from June 2001 to December 2003 (Group B) for anastmosis in our institute, respectively. Albert-Lembert suture was performed as end-to-end gastroduodenostomy followed by resection of proximal line stapled across with liner cutter instrument. The procedure of anastomosis using circular stapling instrument was as followed; the distal duodenum was clamped with the purse-string instrument, divided proximally, the anvil was attached, the purse-string was tied down, the circular stapler without anvil was inserted through a gastrotomy, brought out through a stab wound at the anastomosis site, the instrument was closed and fired, and gastrectomy involving the site of gastrotomy was closed with linear cutter instrument. The followed-up periods of all patients from surgery were more than 2 years. We retrospectively compared the incidence of anastomosis-related complications within 2 years from surgery consisting of anastomotic bleeding, leakage, and stenosis. P-values were calculated statistically using χ2-test. Results: Anastomotic bleeding occurred in 1 (0.45%) patient of Group B, but in none of Group A (P=0.48). Anastomotic leakage occurred in 2 patients (1.80%) of Group A, but in none of Group B (P=0.045). Anastomotic stenosis occurred in 2 patients (0.90%) of Group B, but in none of Group A (P=0.32). All complications were recovered and all patients left hospital in the safety. Conclusions: Our data indicated that circular stapling instrument for anastomosis of Billroth I gastrectomy for gastric cancer significantly reduced the incidence of anastomotic leakage compared with Albert-Lembert suture. No significant financial relationships to disclose.
Phosphoramide Mustard As a Biomarker Of Cyclophosphamide Exposure In Adults Receiving Reduced Intensity Conditioning Hematopoietic Cell Transplantation
Authors: Anthony C. Wiseman, Sanghavi Kinjal, Claudio Brunstein, Erica D. Warlick, Daniel J. Weisdorf, Qing Cao, John Rogosheske, Pamala A. Jacobson
Journal: Blood (2013)
An analysis of DRG-based reimbursement for psychiatric admissions to general hospitals
Authors: M P Freiman, J B Mitchell, M L Rosenbach
Journal: American Journal of Psychiatry (1987)

The authors analyzed the potential financial impact of paying general hospitals on the basis of diagnosis-related groups (DRGs) for Medicare alcohol-drug abuse and psychiatric admissions. Average costs per admission were substantially higher for general hospitals with special psychiatric units that are currently exempt from the prospective payment system (PPS) than for hospitals without exempt units. Simulations of DRG-related payments indicated that these payments would be greater for admissions to hospitals with exempt psychiatric units than for admissions to hospitals without exempt units. However, the differences in costs between these two types of facilities were greater than the differences in payments that would occur under a PPS.
Melanomas of the Eye and Other Noncutan eous Sites: Epidemiologic Aspects
Authors: Joseph Scotto, Joseph F. Fraumeni, J. A. H. Lee
Journal: JNCI Journal of the National Cancer Institute (1976)

The Third National Cancer Survey, 1969-71, reported 432 patients with noncutaneous melanoma, 79% originating in the eye. As with skin melanoma, ocular tumors were more common in whites than blacks and predominated in females at younger ages and males after middle life. On the other hand, ocular melanoma did not show the strong North-South gradient seen with skin melanoma; this suggested no relation to sunlight exposure.
Abstract B04: Early detection of ovarian cancer recurrence using p53-mutated circulating tumor DNA as non-invasive biomarkers.
Authors: Ha-Young Lee, Shin-Wha Lee, Geum-Hee Na, Sang-Eun Lee, Dong-Woo Kang, Yong-Man Kim
Journal: Clinical Cancer Research (2016)

Abstract Objectives: Epithelial ovarian cancer is the most lethal gynecologic cancer and it has a very high recurrence rate. Early detection of recurrence is very important as well as good treatment; however, the accuracy of CA-125 is approximately 50%. Circulating cell-free DNA (cfDNA) carrying tumor-specific somatic alterations, as called circulating tumor DNA (ctDNA), can be isolated from human body fluids. Recently, ctDNA is emerging as a new generation of non-invasive cancer biomarker Moreover ctDNA could be a more sensitive and specific biomarker than CA-125 in epithelial ovarian cancer. According to The Cancer Genome Atlas (TCGA) data, 95% of high-grade serous ovarian cancer (HGS-OC) has mutations in the p53 gene. This study is to investigate that p53-mutated ctDNA could be a biomarker for the early detection of recurrence comparing to CA-125 in HGS-OC. Procedures: We enrolled 85 patients with suspected ovarian cancer from July 2013 to June 2015 and 51 patients were epithelial ovarian cancer. We monitored the level of p53-mutated ctDNA compared with CA-125 in 25 of 38 patients (66%) with HGS-OC who were receiving surgery and continuing chemotherapy treatment. We used targeted-p53 whole exon sequencing to detect somatic genomic alterations from cancer tissue and used droplet digital polymerase chain reaction (ddPCR) to verify ctDNA in serially collected plasma samples. Results: We evaluated ctDNA levels as a monitoring method of the response to chemotherapy and tumor progression. We detected p53 mutations in 38 of 51 women (76%) by whole exon sequencing in cancer tissue and somatic genomic alteration of p53 showed in various sites. Ten of twenty-five (40%) patients who were monitored by ctDNA showed increasing levels of p53-mutated ctDNA during or after scheduled chemotherapy. Even though the ctDNA levels of these 10 patients were increased, the levels of CA-125 were still remained in normal range (under 35 Unit/mL). Especially, 3 patients, the disease progression was observed by imaging method after a few months after the increasing ctDNA. Conclusions: In conclusion, these data suggest that sequential monitoring of p53-mutated ctDNA may have potential as a sensitive and specific biomarker for early detection of recurrence in HGS-OC Citation Format: Ha-Young Lee, Shin-Wha Lee, Geum-Hee Na, Sang-Eun Lee, Dong-Woo Kang, Yong-Man Kim. Early detection of ovarian cancer recurrence using p53-mutated circulating tumor DNA as non-invasive biomarkers. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B04.