tbuckley/cabot-search huggingface dataset:
Interstitial Lung Disease in India. Results of a Prospective Registry
Authors: Sheetu Singh, Bridget F. Collins, Bharat B. Sharma, Jyotsna M. Joshi, Deepak Talwar, Sandeep Katiyar, Nishtha Singh, Lawrence Ho, Jai Kumar Samaria, Parthasarathi Bhattacharya, Rakesh Gupta, Sudhir Chaudhari, Tejraj Singh, Vijay Moond, Sudhakar Pipavath, Jitesh Ahuja, Ravindran Chetambath, Aloke G. Ghoshal, Nirmal K. Jain, H. J. Gayathri Devi, Surya Kant, Parvaiz Koul, Raja Dhar, Rajesh Swarnakar, Surendra K. Sharma, Dhrubajyoti J. Roy, Kripesh R. Sarmah, Bhavin Jankharia, Rodney Schmidt, Santosh K. Katiyar, Arpita Jindal, Daya K. Mangal, Virendra Singh, Ganesh Raghu
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Interstitial lung disease (ILD) is a heterogeneous group of acute and chronic inflammatory and fibrotic lung diseases. Existing ILD registries have had variable findings. Little is known about the clinical profile of ILDs in India.To characterize new-onset ILDs in India by creating a prospective ILD using multidisciplinary discussion (MDD) to validate diagnoses.Adult patients of Indian origin living in India with new-onset ILD (27 centers, 19 Indian cities, March 2012-June 2015) without malignancy or infection were included. All had connective tissue disease (CTD) serologies, spirometry, and high-resolution computed tomography chest. ILD pattern was defined by high-resolution computed tomography images. Three groups independently made diagnoses after review of clinical data including that from prompted case report forms: local site investigators, ILD experts at the National Data Coordinating Center (NDCC; Jaipur, India) with MDD, and experienced ILD experts at the Center for ILD (CILD; Seattle, WA) with MDD. Cohen's κ was used to assess reliability of interobserver agreement.A total of 1,084 patients were recruited. Final diagnosis: hypersensitivity pneumonitis in 47.3% (n = 513; exposure, 48.1% air coolers), CTD-ILD in 13.9%, and idiopathic pulmonary fibrosis in 13.7%. Cohen's κ: 0.351 site investigator/CILD, 0.519 site investigator/NDCC, and 0.618 NDCC/CILD.Hypersensitivity pneumonitis was the most common new-onset ILD in India, followed by CTD-ILD and idiopathic pulmonary fibrosis; diagnoses varied between site investigators and CILD experts, emphasizing the value of MDD in ILD diagnosis. Prompted case report forms including environmental exposures in prospective registries will likely provide further insight into the etiology and management of ILD worldwide.
Is the inherence heuristic simply WEIRD?
Authors: Andrew Scott Baron
Journal: Behavioral and Brain Sciences (2014)

Abstract Although many studies suggest that children and adults focus more on internal causes rather than situational causes to explain observed patterns, such findings may be more limited to WEIRD populations ( w estern, e ducated, i ndustrialized, r ich, d emocratic) samples. Evidence from cross-cultural studies may point to several distinct attribution mechanisms with their culturally specific deployment reflecting both a developmental achievement as well as a possible signal of group boundaries.
Treatment of Neurosyphilis
Authors: R Rothenberg
Journal: BMJ (1947)

Penicillin has some ameliorative effect in every stage of neurosyphilis. Meningovascular disease responds most dramatically. Once anatomic damage has occurred, penicillin is not effective in restoring lost function. In addition, blindness secondary to primary optic atrophy or 8th nerve deafness responds poorly to any type of treatment. Penicillin schedules employing more than 5 million units appear more effective than lower dose regimens. Reports of alternative antibiotic regimens are too fragmentary to allow recommendations to be made.
THU0437 Understanding Between Physician and Patient with Osteoarthritis as a Key Factor in Increasing the Effectiveness of Therapy
Authors: S. Lapshina, L. Myasoutova
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Effective long-term treatment of osteoarthritis (OA) is possible with the active participation of the patient in this process. At the same time, the patient and the doctor9s opinion on this issue are different, which determines the difficulty of effective communication and collaboration with regard to treatment. <h3>Objectives</h3> To identify the most significant problems for the patient with osteoarthritis (OA) in order to create a system of effective interaction between physician and patient in future <h3>Methods</h3> 50 patients with confirmed OA diagnosis (the average duration of the disease 12,45±5,53 years, the average age of patients 49,5±15,82 years) responded to 10 questions concerning their relationship to the disease and the impact on the daily life with the need to evaluate the importance of each question on a scale from 1 to 10. Rheumatologists (n=10) and other physicians (n=40) answered the same questions from their point of view, what is important for patients. Responses were ranked and compared. <h3>Results</h3> Physicians and patients opinions coincided in answering the most important question - the forecast for the future in relation to the possibility of movement and overall health. The second most important for patients was the cost of treatment, the third - understanding the causes of the disease and its consequences. Thereafter, patients worried about constant pain and the need to take drugs constantly and possible side effects. In contrast, doctors believed that patients are worried about limitations in everyday life and disability, persistent pain. To a lesser extent they are concerned about the causes of disease and the cost of therapy. <h3>Conclusions</h3> Understanding the patients opinion to their disease will allow to restructure the communication with the patient, educational programs for them. Physician must pay more attention to the explanation of the causes of disease, the effectiveness and safety of therapy that will improve the quality of life of patients. <h3>Disclosure of Interest</h3> None declared
Transfers of hospitalized psychiatric patients under Medicare's prospective payment system
Authors: M P Freiman, L I Sederer
Journal: American Journal of Psychiatry (1990)

Medicare's reimbursement policy provides payment incentives for hospitals to transfer psychiatric patients to another acute-care facility, especially when the destination facility is exempt from Medicare's prospective payment system. The authors found, however, that transfers were relatively infrequent in 1985, accounting for only approximately 3.4% of all psychiatric hospitalizations under Medicare. The most common type of transfer was from a nonspecialized general hospital bed to a Medicare-exempt psychiatric unit within the same hospital. Given that increasing financial pressures may result in a rise in the number of transfers, the authors discuss potential reforms of Medicare reimbursement for these cases.
Clonazepam in the treatment of recurrent symptoms of depression and anxiety in a patient with systemic lupus erythematosus
Authors: B D Jones, G Chouinard
Journal: American Journal of Psychiatry (1985)

A patient undergoing steroid therapy for systemic lupus erythematosus developed symptoms of depression and anxiety that did not respond to conventional drug therapy. A regimen of clonazepam, an anticonvulsant drug, did relieve the symptoms.
Identification of Neisseria gonorrhoeae isolates with a recombinant porA gene in Scotland, United Kingdom, 2010 to 2011
Authors: K Eastick, A Winter, S Jamdar
Journal: Eurosurveillance (2012)

Three isolates of Neisseria gonorrhoeae have been identified in Scotland in 2010 and 2011, which lack sequences in the porA pseudogene commonly used as the target for confirmatory gonorrhoea polymerase chain reaction assays. Two isolates were clustered temporally and geographically and have the same sequence type and porA sequence. A similar strain was reported in Australia during early 2011. The other Scottish isolate was identified separately and is different in sequence type and porA sequence.
Surgery for obese people with diabetes could save the NHS £100 000 a patient, finds study
Authors: Zosia Kmietowicz
Journal: BMJ (2016)

Using bariatric surgery to treat obese patients with type 2 diabetes could save the NHS around £95 000 (€123 000; $137 000) a patient across their lifetime, British researchers have found. The savings come mostly from reduced drug usage as a result of remission of diabetes.

Robust evidence shows that bariatric surgery improves health in a range of metabolic diseases, including type 2 diabetes. Since 2014 the National Institute for Health and Care Excellence has recommended that people with type 2 diabetes who have a BMI of 35 or …
Clarifying the range of social-cognitive processes subserving human teaching
Authors: Markus Paulus, Sunae Kim, Beate Sodian
Journal: Behavioral and Brain Sciences (2015)

Abstract An evolutionary framework on human teaching is not well equipped to explain the nature of human teaching unless it specifies the subserving cognitive and motivational mechanisms. Only a theory that speculates on the psychological processes provides testable predictions and stimulates further empirical research.
AB0407 Prevalence and Associated Factors of Cervical and Lumbar Spinal Instability in Patients with Rheumatoid Arthritis
Authors: Y. Sugimura, N. Miyakoshi, S. Miyamoto, M. Hongo, Y. Kasukawa, Y. Shimada
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Few studies have compared rheumatoid arthritis (RA)-related disorders of the cervical and lumbar spine. <h3>Objectives</h3> The objectives of this study were to examine the prevalence of and risk factors for cervical and lumbar spinal instability in patients with RA. <h3>Methods</h3> From a total of 1,843 patients registered in the Akita Orthopedic Group on Rheumatoid Arthritis (AORA), 128 patients [111 women, 17 men; mean age, 66 (41–84) years; mean disease duration, 14 (1–63) years] who underwent a radiographic examination were enrolled in this study. In the cervical spine, we defined instability as one of the following characteristics: (1) atlantodental interval (ADI) &gt;3 mm, (2) Ranawat value &lt;13 mm on a neutral plain radiograph, or (3) anteroposterior translation &gt;3 mm at the subaxial cervical spine on an anteroposterior bending plain radiograph. In the lumbar spine, instability was defined as anteroposterior translation &gt;3 mm on a neutral plain radiograph. At the time of radiographs evaluation, demographic characteristics, clinical variables, medical history and current medications were investigated. The patients were classified into two groups: with both cervical and lumbar spinal instabilities and without. The independent risk factors for both cervical and lumbar spinal instabilities were then determined using multivariate logistic regression analysis. <h3>Results</h3> Forty-three (33.6%) patients exhibited cervical spinal instability, and 47 (36.7%) patients exhibited lumbar spinal instability. Twenty-two patients (17.2%) exhibited both cervical and lumbar spinal instability. The presence of both cervical and lumbar spinal instability was significantly and independently associated with disease duration (OR: 1.06; 95% CI: 1.01–1.12). <h3>Conclusions</h3> The prevalence of both cervical and lumbar spinal instability in patients with RA was 17.2%. Disease duration was independent risk factor for presence of both cervical and lumbar spinal instability in this study. <h3>Disclosure of Interest</h3> None declared
“Underwater” endoscopic submucosal dissection: a novel technique for complete resection of a rectal neuroendocrine tumor
Authors: Shunsuke Yoshii, Yoshito Hayashi, Takahiro Matsui, Kenji Aoi, Yoshiki Tsujii, Hideki Iijima, Tetsuo Takehara
Journal: Endoscopy (2016)

Many techniques for endoscopic resection of rectal neuroendocrine tumors (NETs) have been reported [1]. Among these, endoscopic submucosal dissection (ESD) has recently been applied [2]. Although ESD may have the advantage over conventional endoscopic mucosal resection of achieving a complete (R0) resection [3], the crush artifact caused by burn or coagulation from repeated exposure to electric current in this procedure cannot be avoided, and often results in non-R0 resection [4]. We present the case of a rectal NET resected using "underwater" ESD, a new method for complete resection without the creation of unnecessary burn artifacts ([Video 1]).
HCV confirmatory testing of blood donors
Authors: E.A.C Follett, B.C Dow, F McOmish, P Lee Yap, R.J Crawford, R Mitchell, P Simmonds, R.J Crawford, W.D Frame, R Mitchell, Daniel Boudart, Jean-Claude Lucas, Chantal Adjou, Jean-Yves Muller
Journal: The Lancet (1992)
FRI0160 Comparative Drug Survival of Different Non-Anti-TNF IV Biologics After Anti-TNF Failure in Rheumatoid Arthritis Patients
Authors: C. Koutsianas, K. Thomas, C. Hatzara, A. Kandili, C. Tsalapaki, K. Antonatou, D. Vassilopoulos
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> There are limited data to guide the selection of the first non-anti-TNF biologic DMARD (bDMARDs) after anti-TNF failure in rheumatoid arthritis (RA) patients. <h3>Objectives</h3> To evaluate the drug survival of non-anti-TNF IV bDMARDs in RA patients with inadequate response to ≥1 TNF inhibitors (TNF-IR) in daily clinical practice. <h3>Methods</h3> All TNF-IR patients treated with different non-anti-TNF bDMARDS in our center between 01/01/2007 to 31/12/2014 were included in the study. Analyses were stratified by the first biologic agent used after TNF failure (Tocilizumab-TCZ, Rituximab-RTX, Abatacept-ABA) and then by RF status and conventional synthetic DMARD (csDMARD) administration. Kaplan-Meier survival analysis and log-rank test of equality pairwise over strata were performed. <h3>Results</h3> 94 TNF-IR consecutive RA patients treated with TCZ (n=24), RTX (n=49) or ABA (n=21) were included and followed for 24.2±18.8 months. 84/94 (89.4%) were women with a mean age of 64.5±15 years, rheumatoid factor (RF) positive were 49/94 (52%) patients. The baseline characteristics did not differ between the 3 groups, except from RF positivity which was more common in the RTX group compared to the TCZ group (p=0.01). The drug survival rates for TCZ, RTX and ABA were 79%, 83% and 76% at 12 months and 60%, 68%, 44% at 24 months, respectively (p=NS). Similarly, the mean time for drug discontinuation was 29.7, 41.7 and 27.1 months respectively and did not differ between groups (p=NS). Among RF+ patients, RTX (p=0.007) and TCZ (p=0.05) demonstrated better survival compared to ABA while there was no difference in drug survival among RF negative patients. There was a tendency for better drug survival among RA patients treated with RTX in combination with csDMARDs compared to combination ABA therapy (p=0.06) but this did not reach statistical significance. <h3>Conclusions</h3> In this observational retrospective study, overall there was no significant difference in drug survival, between non-anti-TNF bDMARDs after anti-TNF failure, with the exception of RF+ patients where RTX and TCZ demonstrated better survival compared to ABA. <h3>Acknowledgements</h3> This work was supported in part by research grants from the Special Account for Research Grants (S.A.R.G.), National and Kapodistrian University of Athens, Athens, Greece. <h3>Disclosure of Interest</h3> None declared
Drug Therapy in Hypertension.
Authors: I Gavras, A Manolis, H Gavras
Journal: Annals of Internal Medicine (1987)

By matching the profile of an antihypertensive drug to the clinical and demographic characteristics of the patient (e.g., risk factors, coexisting diseases, goals of therapy beyond lowering blood pressure), the physician can maximize the efficacy of the regimen and minimize the adverse effects the patient may experience. Optimal therapy requires a knowledge of the pharmacologic properties of the six broad classes of antihypertensive drugs: diuretics, sympatholytics (including central and peripheral adrenergic receptor blockers), direct vasodilators, angiotensin-converting enzyme inhibitors, calcium channel blockers and angiotensin II receptor antagonists.
Correlation Between Yoshida Sarcoma and Human Neoplastic Disease In Cancer Chemotherapy Studies&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Shigetsugu Katsura, Ko Sato, Kenichi Akaishi, Kazuhiro Harada, Rintaro Sato
Journal: JNCI Journal of the National Cancer Institute (1959)

Experimental and clinical cancer chemotherapy studies with Yoshida sarcoma in rats and in 61 inoperable or advanced cancer patients are reported. The chemicals used were colchicine derivatives, p-phenylenediphosphoric acid tetraethyleneimid (RC4), and 1-thia-3-azaazulan-2-one (Az.). In these studies, combination chemotherapy with RC4 and Az. showed the best results. The combined use of 2 substances which have entirely different modes of action prevented growth of resistant tumor cells, and effective treatment by a small amount of long-term continued injections on tumor cells was substantiated. A number of patients with carcinoma of the breast, lung, and digestive tract showed objective or subjective improvement by the combination chemotherapy. If properly used, chemotherapy appears to have merit as an additive method in conjunction with surgical intervention in the treatment of certain types of inoperable and metastatic cancer, though a high rate of long-term survivors was not obtained with the present combination chemotherapy.
Adjunctive Medroxyprogesterone Acetate to Radical Nephrectomy in Category M(0) Renal Cell Carcinoma
Authors: G. Pizzocaro, G. Di Fronzo, L. Piva, R. Salvioni, E. Ronchi, V. Cappelletti, A. Giongo, E. Mastroberardino, C. Cozzoli, E. Dormia, S. Minervini, A. Zanollo, U. Fontanella, R. Giannoni, A. Maggioni, E. Lasio
Journal: European Urology (1983)
Poststerilization Syndrome
Authors: J M REVERTE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPUTERS AND THE EYE
Authors: W C WESCOE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
WAR: INTEREST DUE AND PAYABLE
Authors: F E DELMUNDO, A OCAMPO, L E BARRION, E MANIQUIZ
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Special Cure
Authors: Robert J. Hoffman, Gurpreet Dhaliwal, Daniel J. Gilden, Sanjay Saint
Journal: New England Journal of Medicine (2004)

A 42-year-old white man presented with a history of eight months of pain in his low back, hips, ankles, and feet. He had begun experiencing progressively severe pain during a 16-month period of incarceration, to the extent that he was having difficulty walking. He had also lost weight (from 76.2 to 67.6 kg) without a change in diet.
Effects of recombinant alpha and gamma interferons on the in vitro growth of circulating hematopoietic progenitor cells (CFU-GEMM, CFU-Mk, BFU-E, and CFU-GM) from patients with myelofibrosis with myeloid metaplasia
Authors: C Carlo-Stella, M Cazzola, A Gasner, G Barosi, L Dezza, F Meloni, P Pedrazzoli, D Hoelzer, E Ascari
Journal: Blood (1987)
Ectopic Drainage of the Common Bile Duct into the Duodenal Bulb: Report of Two Cases
Authors: E.  Özaslan, Ü.  Sarıtaş, G.  Tatar, H.  Şimşek
Journal: Endoscopy (2003)

During endoscopic retrograde cholangiopancreatography (ERCP) in a 52-year-old man with acute cholangitis, the major papilla could not be found, but a slit-like bile-stained orifice was present at the anterior part of the deformed bulb. Dilatation of the biliary tree was seen and a 7-Fr plastic stent was introduced to drain the biliary system (Figure [1]). Clinical resolution was obtained within a few days, and the patient remained asymptomatic at 5 months after the procedure.