tbuckley/cabot-search huggingface dataset:
Gain of 1q as a Potential Adverse Prognostic Marker in Myelodysplastic Syndrome: Comparison with International Prognostic Scoring System Variables
Authors: Hyun-Kyung Park, Dong Soon Lee, Hye Ryun Lee, Han Ik Cho, Hyun Kyung Kim, Sung-Soo Yoon, Byoung Kook Kim
Journal: Blood (2008)
Allogeneic T-Cells Expressing an Anti-CD19 Chimeric Antigen Receptor Cause Remissions of B-Cell Malignancies after Allogeneic Hematopoietic Stem Cell Transplantation without Causing Graft-Versus-Host Disease
Authors: Jennifer N Brudno, Robert Somerville, Victoria Shi, Jeremy J. Rose, David C. Halverson, Daniel H. Fowler, Dennis D. Hickstein, Juan C. Gea-Banacloche, Steven Z. Pavletic, Andre Goy, Tangying L Lu, Steven Feldman, Alex Iwamoto, Roger Kurlander, Irina Maric, Brenna Hansen, Jennifer S. Wilder, Bazetta Blacklock-Shuver, Frances T. Hakim, Steven A. Rosenberg, Ronald E. Gress, James N. Kochenderfer
Journal: Blood (2015)
P0679 : Derisking the potential for mitochondrial toxicity of nucleoside analogs
Authors: Z. Jin, J. Deval, J.A. Symons, H. Tan, K. Shaw, S.M. Chanda, Q. Zhang, Y. Tam, L.M. Blatt, G. Wang, N. Dyatkina, L. Beigelman, D.B. Smith
Journal: Journal of Hepatology (2015)
Expression Profiling of CD34+ Cells in Patients with Myelodysplastic Syndromes: Involvement of Interferon-Stimulated Genes and Correlation to FAB Subtype and Karyotype.
Authors: Andrea Pellagatti, Mario Cazzola, Aristoteles Giagounidis, Luca Malcovati, Matteo G. Della Porta, Martin Jädersten, Sally Killick, Carrie Fidler, David Oscier, David Bowen, Carlo Aul, Eva Hellström-Lindberg, James S. Wainscoat, Jacqueline Boultwood
Journal: Blood (2006)
Prognostic Impact of C-Kit Mutations in Core Binding Factor-Leukemia.
Authors: Roberto Cairoli, Alessandro Beghini, Gianpaolo Nadali, Francesca Elice, Maria Lunghi, Antonio Cuneo, Giovanni Grillo, Michele Nichelatti, Carla B. Ripamonti, Mario Lazzarino, Francesco Rodeghiero, Giovanni Pizzolo, Lidia Larizza, Enrica Morra
Journal: Blood (2004)
An Open-Label, Phase 1 Study Evaluating the Safety and Pharmacokinetics of Pralatrexate in Relapsed/Refractory Advanced Solid Tumors or Advanced Lymphoma/Myeloma Patients with Mild, Moderate, and Severe Renal Impairment
Authors: Kevin R. Kelly, Nashat Y. Gabrail, William J Edenfield, A Craig Lockhart, Anthony J. Olszanski, Guru Reddy
Journal: Blood (2015)
NIMG-60TREATMENT RESPONSE KINETICS AND EXCEPTIONAL SURVIVAL IN GLIOBLASTOMA
Authors: Corbin Rayfield, Sandra Johnston, Scott Whitmire, Laura Guyman, Kristin Swanson
Journal: Neuro-Oncology (2015)

Although glioblastoma (GBM) is considered a uniformly fatal disease, roughly 2-5% of GBM patients survive longer than 5 years.In this study, we sought to elucidate how response to treatment may be similar or different in long-term survivors (LTS) defined as living longer than 3 years (n ¼ 12) versus patients with typical overall survival (,3 years) (n ¼ 36).Pre-treatment, response to radiation, time to minimum volume, and posttreatment tumor growth kinetics were compared.Newly diagnosed GBM Overall survival
SP0047 Circadian Clocks and Inflammation: The Clock as A Pharmacological Target for Inflammatory Disease
Authors: J.E. Gibbs
Journal: Annals of the Rheumatic Diseases (2016)

The circadian clock is a biological timing mechanism that allows organisms to align their physiology with the external daily environment. 24h rhythms are generated within every cell by a transcriptional-translational feedback loop, the cellular clock. It is now evident that the cellular clock operates within the immune system, and this explains how responses to inflammatory stimuli show circadian variation. A prime example of this is the macrophage, which is capable of generating 24h rhythms <i>in vivo</i>, but also <i>ex vivo</i> in the absence of entraining signals. Macrophage responses (pro-inflammatory cytokine release) to inflammatory stimuli are significantly greater if the provocation occurs at dusk compared to dawn. Genetic ablation of the clock, by deletion of <i>bmal1</i>, in macrophages, renders them arrhythmic, and results in loss of this time of day variation in response. The cellular clock transmits timing information through REV-ERB alpha, a nuclear hormone receptor and transcriptional repressor. From this we discovered REV-ERB alpha is a tractable pharmacological target for inflammatory disease. Other cell types involved in the pathogenesis of inflammatory arthritis are also intrinsically rhythmic, including T cells, dendritic cells and synovial fibroblasts. Indeed, using mouse collagen-induced arthritis we have shown that levels of inflammatory markers within inflamed joints show robust 24h rhythmicity. Transcript levels of <i>il1b</i> and <i>il6</i> peak at dawn, which is remarkably consistent with clinical observations, showing a rise in circulating levels of cytokines in the early morning. Further analysis revealed that the negative arm of the molecular clock (specifically CRYPTOCHROME) suppresses arthritis during the night. Furthermore, small molecule CRYPTOCHROME activators were found to have anti-inflammatory actions in both murine and human synovial fibroblasts – re-affirming the notion that the circadian clock is a therapeutic target for inflammatory disorders. <h3>Disclosure of Interest</h3> None declared
Continued Low-Dose Decitabine (DAC) Is an Active First-Line Treatment in All Cytogenetic Subgroups of Older AML Patients: Results of the FR00331 Multicenter Phase II Study.
Authors: Michael Lübbert, Björn Rüter, Rainer Claus, Mathias Schmid, Ulrich Germing, Hartmut Eimermacher, Arnold Ganser, Uwe Platzbecker, Oliver Galm, Wolfram Brugger, Gerhard Heil, Pierre W. Wijermans, Dietmar Pfeifer, Claudia Schmoor, Hartmut Döhner
Journal: Blood (2007)
The BH3-Mimetic Obatoclax (GX15-070) Posses a Dual-Mechanism of Action and Induces Both Apoptosis and Autophagy-Dependent Cell Death of B Cell Non-Hodgkin’s Lymphoma (B-NHL) Cells
Authors: Francisco J. Hernandez-Ilizaliturri, Sapna Khubchandani, Scott H. Olejniczak, Paul Hosking, Elizabeth Gruber, Myron Czuczman
Journal: Blood (2008)
Systems analysis identifies miR-29b regulation of invasiveness in melanoma
Authors: Miles C. Andrews, Joseph Cursons, Daniel G. Hurley, Matthew Anaka, Jonathan S. Cebon, Andreas Behren, Edmund J. Crampin
Journal: Molecular Cancer (2016)

In many cancers, microRNAs (miRs) contribute to metastatic progression by modulating phenotypic reprogramming processes such as epithelial-mesenchymal plasticity. This can be driven by miRs targeting multiple mRNA transcripts, inducing regulated changes across large sets of genes. The miR-target databases TargetScan and DIANA-microT predict putative relationships by examining sequence complementarity between miRs and mRNAs. However, it remains a challenge to identify which miR-mRNA interactions are active at endogenous expression levels, and of biological consequence. We developed a workflow to integrate TargetScan and DIANA-microT predictions into the analysis of data-driven associations calculated from transcript abundance (RNASeq) data, specifically the mutual information and Pearson's correlation metrics. We use this workflow to identify putative relationships of miR-mediated mRNA repression with strong support from both lines of evidence. Applying this approach systematically to a large, published collection of unique melanoma cell lines – the Ludwig Melbourne melanoma (LM-MEL) cell line panel – we identified putative miR-mRNA interactions that may contribute to invasiveness. This guided the selection of interactions of interest for further in vitro validation studies. Several miR-mRNA regulatory relationships supported by TargetScan and DIANA-microT demonstrated differential activity across cell lines of varying matrigel invasiveness. Strong negative statistical associations for these putative regulatory relationships were consistent with target mRNA inhibition by the miR, and suggest that differential activity of such miR-mRNA relationships contribute to differences in melanoma invasiveness. Many of these relationships were reflected across the skin cutaneous melanoma TCGA dataset, indicating that these observations also show graded activity across clinical samples. Several of these miRs are implicated in cancer progression (miR-211, -340, -125b, −221, and -29b). The specific role for miR-29b-3p in melanoma has not been well studied. We experimentally validated the predicted miR-29b-3p regulation of LAMC1 and PPIC and LASP1, and show that dysregulation of miR-29b-3p or these mRNA targets can influence cellular invasiveness in vitro. This analytic strategy provides a comprehensive, systems-level approach to identify miR-mRNA regulation in high-throughput cancer data, identifies novel putative interactions with functional phenotypic relevance, and can be used to direct experimental resources for subsequent experimental validation. Computational scripts are available: http://github.com/uomsystemsbiology/LMMEL-miR-miner
Efficacy and Safety of Bortezomib Based Regimens Retreatment in Relapsed Multiple Myeloma Patients: Results from a Retrospective Study.
Authors: Wenjun Wu, Gaofeng Zheng, Xiaoyan Han, Yi Zhao, Donghua He, Yang Yang, Jingsong He, Weiyan Zheng, Jie Sun, Jimin Shi, Guoqing Wei, He Huang, Zhen Cai
Journal: Blood (2015)
Гастроезофагеальна рефлюксна хвороба і лужний рефлюкс: механізми розвитку і тактика лікування
Authors: T.D. Zviahintseva, I.I. Sharhorod
Journal: GASTROENTEROLOGY (2016)

Стаття присвячена гастроезофагеальній рефлюксній хворобі (ГЕРХ) — патології, що займає провідне місце серед усіх кислотозалежних захворювань. Основним механізмом розвитку ГЕРХ є порушення моторно-евакуаторної функції шлунка — уповільнення шлункової евакуації і дуоденогастральний рефлюкс. Уповільнене спорожнення шлунка сприяє почастішанню рефлюксу, а наявність дуоденального вмісту в рефлюктаті — лужний рефлюкс — є агресивним для слизової оболонки стравоходу (СОС). Це обумовлено наявністю в рефлюктаті, що закидається в стравохід, жовчних кислот, лізолецитину і панкреатичних ферментів. Тривало існуючий контакт агресивних чинників у шлунку і стравоході призводить до розвитку запально-деструктивних уражень слизової оболонки цих органів. За даними багатьох дослідників, саме жовчні кислоти відіграють провідну роль у патогенезі шкідливого впливу на СОС. Медикаментозна корекція ГЕРХ із лужним рефлюксом включає поряд із призначенням інгібіторів протонної помпи прокінетики (ітоприду гідрохлорид) і препарати урсодезоксихолієвої кислоти.
Serum Free Light Chain Ratio (FLCr) Is a Powerful Prognostic Factor For Survival In Newly Diagnosed Multiple Myeloma (MM) In The Era Of New Agents Namely On ISS Stage II Patients
Authors: Graça V Esteves, Manuel L Neves, Helena F Martins, Maria Joao Costa, Sara Valle, João Raposo, Carlos M. Martins, Lurdes Guerra, Conceição Lopes, Susana Mendes, Ana Alho, Rita Ferreira, Carolina Viveiros, Eduardo Espada, Inês Conde, Daniela Alves, Joao F Lacerda, Blanca Polo, Helena Proença, José A Carmo
Journal: Blood (2013)
Gene Expression Studies May Identify Lower Risk Myelodysplastic Syndrome Patients Likely to Respond to Therapy with Ezatiostat Hydrochloride (TLK199)
Authors: Naomi Galili, Pablo Tamayo, Olga B Botvinnik, Jill P Mesirov, Jennifer Zikria, Gail Brown, Azra Raza
Journal: Blood (2011)
Preclinical Rationale for the Use of the Multikinase Inhibitor Sorafenib in the Treatment of Human Lymphomas
Authors: Carmelo Carlo-Stella, Cristiana Lavazza, Arianna Giacomini, Loredana Cleris, Daniela Sia, Paolo Longoni, Marco Milanesi, Michele Magni, Massimo Di Nicola, Annunziata Gloghini, Antonino Carbone, Marco Righi, Franca Formelli, Alessandro M. Gianni
Journal: Blood (2008)
THU0225 Hypogonadotropic Hypogonadism in Systemic Arthritis- An Interesting Case Series from A Tertiary Care Centre
Authors: B. Chilukuri, R. Sankaralingam, S. Sankar, R. Ramamoorthy, B. Mahendran
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The musculoskeletal, cardiac, pulmonary, hepatic, reticuloendothelial, hematological, neurological manifestations of systemic arthritis are very well known. Hormonal abnormalities of systemic arthritis have not been reported thus far <h3>Objectives</h3> To study hormone profile in systemic arthritis and identify abnormalities <h3>Methods</h3> We present a case series of abnormal hormone profile in 5 consecutive cases of Systemic arthritis admitted and evaluated at Institute Of Rheumatology, Madras Medical College during Februrary 2015. All patients had high systemic disease activity – elevated ESR, CRP, ferritin, fibrinogen, thrombocytosis. Fasting serum hormone profile was done by chemiluminescence method – Adrenocorticotropin releasing hormone (ACTH), Thyroid stimulating hormone (TSH), Follicle stimulating hormone (FSH), Luteinizing hormone (LH), Prolactin, Testosterone, Insulin like growth factor-1 (IGF-1), Growth hormone (GH) were estimated. <h3>Results</h3> All 5 patients had low serum FSH,LH,GH,Testosterone levels. All 5 patients had normal ACTH,TSH,prolactin levels. * indicates LOW VALUES <h3>Conclusions</h3> –Hypogonadotrophic secondary hypogonadism was observed in 5 consecutive patients with systemic arthritis with high disease activity. –We are presenting this case series as no studies have so far been reported on hormone profile of patients with systemic arthtritis to the best of our knowledge. –Further studies with more number of cases are needed to find out whether the endocrine dysfunction is disease related or drug induced. <h3>References</h3> Harel L, Prais D, Uziel Y, Mukamel M, Hashkes P, Harel G, Amir J, Monselise Y, Press J.Increased prevalence of antithyroid antibodies and subclinical hypothyroidism in children with juvenile idiopathic arthritis. J Rheumatol. 2006 Jan;33(1):164–6 Bechtold S, Ripperger P, Häfner R, Said E, Schwarz HP. Growth hormone improves height in patients with juvenile idiopathic arthritis: 4-year data of a controlled study.J Pediatr. 2003 Oct;143(4):512–9. Khalkhali-Ellis Z, Moore TL, Hendrix MJ. Reduced levels of testosterone and dehydroepiandrosterone sulphate in the serum and synovial fluid of juvenile rheumatoid arthritis patients correlates with disease severity. Clin Exp Rheumatol. 1998 Nov-Dec;16(6):753–6. <h3>Disclosure of Interest</h3> None declared
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
Authors: Shira L Cramer, Achinto Saha, Jinyun Liu, Surendar Tadi, Stefano Tiziani, Wupeng Yan, Kendra Triplett, Candice Lamb, Susan E Alters, Scott Rowlinson, Yan Jessie Zhang, Michael J Keating, Peng Huang, John DiGiovanni, George Georgiou, Everett Stone
Journal: Nature Medicine (2016)
AB0975 Diffusion Weight Magnetic Resonance Imaging May Predict A Treatment Response in Ankylosing Spondylitis
Authors: S.Y. Lee, W.T. Chung, S.W. Lee
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> With the today`s advanced magnetic resonance imaging (MRI) techniques, the pathologic features of ankylosing spondylitis (AS) can be detected early and promptly treatment. <h3>Objectives</h3> This study aimed to determine the value of diffusion-weighted MR imaging (DWI) in determined of AS treatment strategy and assess the role of quantitative MRI in the evaluation of AS treatment outcome. <h3>Methods</h3> 52 patients with the diagnosis of early AS were included in this study. Disease activity was measured according to clinical instruments and laboratory tests. For each patient, both inflamed sacroiliac (S-I) joint lesion was checked quantitatively at first diagnosis by diffusion-weighted MR imaging (DWI) and measured the apparent diffusion coefficient (ADC). Based on ADC value, low ADC value group were treated with conventional NSAIDs and high ADC value group were treated with TNF-α inhibitor. all subjects were revaluated continuously by pelvis multi-directional computer tomography (MDCT) for bone change in sacroiliac joint, after treatment. <h3>Results</h3> The high ADC value patient had higher BASDIA score, ESR and CRP than low ADC value patients relatively. The clinical parameters diminished significantly with regression of the inflammatory activity after treated with TNF-α inhibitor or NSAIDs. But paradoxically, one patient who was low ADC value and treated with NSAID had radiologic change of S-I joint and no change of ADC value in follow up MRI. <h3>Conclusions</h3> The ADC value measured by DWI maybe predicted treatment response. <h3>References</h3> Braun J, Sieper J. Ankylosing spondylitis. Lancet 2007;369:1379–90. <h3>Disclosure of Interest</h3> None declared
A Novel Assay for Juvenile Myelomonocytic Leukemia Based on Aberrant Signaling Networks Measured Via Phospho-Specific Flow Cytometry Reduces Diagnosis Time from Weeks to Days.
Authors: Nikesh Kotecha, Nikki J. Flores, Jonathan M. Irish, Debbie Sakaguchi, Sophie Archambeault, Ernesto Diaz-Flores, Marc Coram, Kevin M. Shannon, Garry P. Nolan, Mignon L. Loh
Journal: Blood (2007)
Lenalidomide Induces Capping of CD20 and Cytoskeleton Proteins to Enhance Rituximab Immune Recognition of Malignant B-Cells
Authors: Svetlana Gaidarova, Derek Mendy, Carla Heise, Sharon Lea Aukerman, Tom Daniel, Rajesh Chopra, Antonia Lopez-Girona
Journal: Blood (2010)
Therapy for Cellulitis
Authors: Vivek Kak
Journal: JAMA (2016)

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Pre-vascularization Enhances Therapeutic Effects of Human Mesenchymal Stem Cell Sheets in Full Thickness Skin Wound Repair
Authors: Lei Chen, Qi Xing, Qiyi Zhai, Mitchell Tahtinen, Fei Zhou, Lili Chen, Yingbin Xu, Shaohai Qi, Feng Zhao
Journal: Theranostics (2016)

Split thickness skin graft (STSG) implantation is one of the standard therapies for full thickness wound repair when full thickness autologous skin grafts (FTG) or skin flap transplants are inapplicable. Combined transplantation of STSG with dermal substitute could enhance its therapeutic effects but the results remain unsatisfactory due to insufficient blood supply at early stages, which causes graft necrosis and fibrosis. Human mesenchymal stem cell (hMSC) sheets are capable of accelerating the wound healing process. We hypothesized that pre-vascularized hMSC sheets would further improve regeneration by providing more versatile angiogenic factors and pre-formed microvessels. In this work, in vitro cultured hMSC cell sheets (HCS) and pre-vascularized hMSC cell sheets (PHCS) were implanted in a rat full thickness skin wound model covered with an autologous STSG. Results demonstrated that the HCS and the PHCS implantations significantly reduced skin contraction and improved cosmetic appearance relative to the STSG control group. The PHCS group experienced the least hemorrhage and necrosis, and lowest inflammatory cell infiltration. It also induced the highest neovascularization in early stages, which established a robust blood micro-circulation to support grafts survival and tissue regeneration. Moreover, the PHCS grafts preserved the largest amount of skin appendages, including hair follicles and sebaceous glands, and developed the smallest epidermal thickness. The superior therapeutic effects seen in PHCS groups were attributed to the elevated presence of growth factors and cytokines in the pre-vascularized cell sheet, which exerted a beneficial paracrine signaling during wound repair. Hence, the strategy of combining STSG with PHCS implantation appears to be a promising approach in regenerative treatment of full thickness skin wounds.
FRI0468 High Prevalence of Us Determined Subclinical Synovitis in Early Psoriatic Arthritis Correlates Better with The SJC Rather than TJC: Results from The Leeds Sparro Cohort: Table 1.
Authors: M. Merashli, L. Horton, E. Hensor, G. De Marco, M.A. D'agostino, A.L. Tan, P. Emery, D. Mcgonagle, H. Marzo-Ortega
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Ultrasound (US) is known to be more sensitive than clinical examination in detecting synovitis in psoriatic arthritis (PsA). However, some studies found disparity between the US and clinical findings <h3>Objectives</h3> To assess the prevalence of synovial involvement in early PsA using clinical and sonographic assessments. <h3>Methods</h3> A total of 49 subjects with early PsA (CASPAR criteria) recruited in the Leeds Spondyloarthropathy Register for Research and Observation (SpARRO) study, a prospective longitudinal observational cohort, was assessed. The mean disease duration is 1.6 ±0.5 years; F:M ratio is 1.3; median SJC76 is 2 (1–2), median TJC78 is 6 (3–17); 90% of subjects had current skin psoriasis. Baseline US scan was performed on 1274 joints including bilateral wrists, MCP2–3, PIP2–3, elbows, knees, ankles &amp; MTP 1–5. Grey Scale (GS) and Power Doppler (PD) were scored on a 0–3 semi-quantitative scale for each joint. Joints were considered clinically active if tender or swollen, and sonographically active if GS≥2 and/or PD≥1. We compared US active (yes/no) against tender (yes/no) and swollen (yes/no). The majority of the patients (88%) were DMARD naive <h3>Results</h3> US identified a higher proportion of subclinical synovitis among swollen rather than tender joints in subjects with early PsA. The agreement between clinical examination (tender &amp; swollen) and US findings was high (73 &amp; 87%) respectively. The most common sites for subclinical synovitis were MTP joints. In contrast, wrist tenderness and MTP2 swelling were the highest overestimated joints among the physical examination. <h3>Conclusions</h3> The prevalence of subclinical synovitis is high in early PsA. Joint swelling is more likely to correlate with PD or GS in PsA when compared to joint tenderness. As opposed to RA, where clinical tenderness correlates with subclinical synovitis, the tender joint count may not be a reliable clinical measure to assess synovitis in PsA. Possible reasons for the over-estimation of TJC in clinical examination may be the concomitant occurrence of fibromyalgia. Larger studies are needed to confirm our results. <h3>Disclosure of Interest</h3> None declared