tbuckley/cabot-search huggingface dataset:
Cimetidine
Authors: Jan Koch-Weser, Warren Finkelstein, Kurt J. Isselbacher
Journal: New England Journal of Medicine (1978)

WITH the synthesis of burimamide in 1972, Black and his colleagues1 demonstrated the existence of two classes of histamine receptors, H1 and H2. In contrast to the H1 type, H2 receptors are not antagonized by "classic" or conventional antihistamines and are involved in the action of histamine on the gastric parietal cell. Burimamide, the first histamine H2 antagonist, was found to block histamine-stimulated gastric acid secretion selectively but was not active orally. Cimetidine was subsequently synthesized when the second H2-receptor antagonist, metiamide, was found to cause agranulocytosis. The structures of histamine and . . .
WHO European Region's strategy for elimination of measles and congenital rubella infection
Authors: F X Hanon, J. Spika John, S. Wassilak Steven, N Emiroglu
Journal: Eurosurveillance (2003)

The WHO strategy for measles elimination in Europe includes the strengthening of surveillance and immunisation programmes in collaboration with European specific networks (EUVAC.NET and CCEE-Baltic) and Member States.
Leukemia Stem Cell Marker CD123 (IL-3R alpha) Predicts Minimal Residual Disease and Relapse, Providing a Valid Target For SL-101 In Acute Myeloid Leukemia With FLT3-ITD Mutations
Authors: Lina Han, Jeffrey L. Jorgensen, Sa A. Wang, Xuelin Huang, Graciela M Nogueras González, Christopher Brooks, Eric Rowinsky, Mark Levis, Jin Zhou, Stefan O. Ciurea, Gheath Alatrash, Jorge E. Cortes, Hagop M. Kantarjian, Michael Andreeff, Farhad Ravandi, Marina Konopleva
Journal: Blood (2013)
FRI0447 Temporomandibular Joint and Chewing Features in Systemic Sclerosis Patients: A Clinical and Magnetic Resonance Imaging Analysis
Authors: G. Matarese, G. Isola, A. Alibrandi, A. Lo Gullo, G. Bagnato, G. Cordasco, L. Perillo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The pathogenesis of Systemic Sclerosis (SSc) remains unknown, but increasing evidence suggests that activation of lesional fibroblasts contributes to the fibrotic process. SSc is characterized by symmetric, erosive synovitis, which may result in joint irregularity and disability. <h3>Objectives</h3> The purpose of this clinical study was to assess the prevalence and characteristics of Temporomandibular joint (TMJ) symptoms, clinical and Magnetic Resonance Imaging (MRI) findings in a cohort of patients with SSc. <h3>Methods</h3> 27 patients with SSc (12 Diffuse, 15 Limited, mean age 53.9, SD ±1.2) and 28 healthy subjects (mean age 54.8, SD ±4.2) were enrolled in this cohort study. Oro-facial clinical examination for assessing the presence of TMJ sounds, pain in the TMJ area, tenderness of masticatory muscles, limited mouth opening, pain assessment, MRI scan and Anamnestic and Dysfunctional Index were achieved in all of patients. <h3>Results</h3> The test groups presented more clinical and MRI TMJ symptoms and dysfunction than Control group. The distributions of symptoms were significantly different (P&lt;0.05), in the Test groups for TMJ sounds, pain during mandibular movement and difficulty in the maximum mouth opening. There was also a significant decrease (P&lt;0.001), in the Test groups, in the mean of leftward, rightward laterotrusion and protrusion. Correlation analysis showed that maximum opening leftward laterotrusion, protrusion and click were significantly correlated to Modified Rodnan Skin Score. The mean duration of disease was significantly correlated, ever in Total SSc group, only for the maximum mouth opening value. <h3>Conclusions</h3> This study proves that TMJ dysfunction is a common feature in SSc patients and it is correlated with a extent and involvement of disease and supports the notion that TMJ examination should be encouraged in rheumatology and clinicians should provide a patient support and a right pain management. <h3>References</h3> Jelaska A, Arakawa M, Broketa G, Korn JH. Heterogeneity of collagen synthesis in normal and systemic sclerosis skin fibroblasts: increased proportion of high collagen–producing cells in systemic sclerosis fibroblasts. Arthritis Rheum 1996;39:1338–46. Schieir O, Thombs BD, Hudson M, Boivin JF, Steele R, Bernatsky S, et al. Canadian Scleroderma Research Group. Prevalence, severity, and clinical correlates of pain in patients with systemic sclerosis. Arthritis Care Res (Hoboken). 2010;62:409-17. <h3>Disclosure of Interest</h3> None declared
Giant Cell Tumor of the Tendon Sheath With Discordant Metabolism as a False Positive on Staging of Mantle Cell Lymphoma
Authors: Alireza Rezaee, Wengen Chen, Vasken Dilsizian, Qing Chen, Amy S Kimball
Journal: Clinical Nuclear Medicine (2015)

A baseline 18F-FDG PET/CT scan in a patient with mantle cell lymphoma showed diffuse minimally FDG-avid lymphadenopathy and splenomegaly. There was also a focus of uptake in the left subscapularis muscle without a CT correlate. A post-chemotherapy scan showed interval decrease in size, and resolution of FDG uptake, of the lymph nodes and spleen. Persistent activity was seen in the subscapularis muscle. Posttreatment biopsy of the FDG-avid lesion showed a benign giant cell tumor of tendon sheath. This case illustrates that a lesion with a markedly discordant SUV should raise suspicion for a second process.
Involvement of the Cellular Vacuolar System with the Cytotoxicity of Bleomycin-like Agents
Authors: J S Lazo, J C Schisselbauer, G M Herring, K A Kennedy
Journal: Cancer Communications (1990)

The role of acidic cellular organelles in regulating the toxicity of selected antitumor drugs was studied with L1210 cells using modifiers of vesicular pH or function. A 1 hr exposure to a non-toxic concentration of the acidotropic weak base ammonium chloride increased the lethality of bleomycin A2 (BLM A2), demethyl BLM A2, peplomycin, and talisomycin S10b to L1210 cells grown in culture. Enhanced BLM lethality was also seen with the lysosomal disruptive agents verapamil and diltiazem. The increased lethality with verapamil and BLM A2 was schedule dependent, being seen only when cells were exposed to the drugs simultaneously or to BLM A2 first and then verapamil. Non-toxic concentrations of the monovalent cationic ionophore monensin also increased the cytotoxicity of BLM A2 and talisomycin S10b but not doxorubicin. This enhanced cytotoxicity seen with monensin occurred without an increase in either cell associated BLM A2 or single-strand DNA damage as measured by alkaline elution. We propose that acidic cellular organelles or their contents participate in controlling the cytotoxicity of the BLM class of antitumor agents.
Circulating antigen levels in ovarian cancer.
Authors: R Colomer, J Genollà, J M del Campo, A Ruibal
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.7.1148 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3723170 Circulating antigen levels in ovarian cancer. R ColomerxR ColomerSearch for articles by this author , J GenollàxJ GenollàSearch for articles by this author , J M del CampoxJ M del CampoSearch for articles by this author , A RuibalxA RuibalSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.7.1148 PDF "Circulating antigen levels in ovarian cancer.." Journal of Clinical Oncology, 4(7), pp. 1148–1149© 1986 by American Society of Clinical Oncology
SAT0395 Factors Influencing Patient-Reported Indexes in Primary SjÖgren's Syndrome: A Multicenter Experience
Authors: C. Baldini, R. Priori, F. Carubbi, E. Bartoloni, L. Quartuccio, A. Alunno, S. Colafrancesco, G. Valesini, R. Giacomelli, R. Gerli, S. De Vita, S. Bombardieri
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> 1) to explore patient-reported symptoms in a large series of patients with primary Sjögren9s syndrome using the recently-proposed ESSPRI questionnaire and to assess the relationship between the ESSPRI and patient demographics and disease characteristics (duration, activity, organ damage) 2) to evaluate the impact of patient-reported symptoms on oral and ocular health-related quality of life (HRQoL) <h3>Methods</h3> This multicenter cross-sectional involved five Italian reference centers with substantial experience in the management of pSS. Between July 2014 and November 2014, 360 pSS patients (AECG criteria) seen consecutively, were enrolled. A standardized data set including demographic, clinical and serological disease manifestations was collected prospectively. The ESSDAI and the SSDDI were used to assess disease activity and organ damage, respectively. All patients completed the ESSPRI questionnaire. Oral HRQoL was evaluated using the Oral Health Impact Profile (OHIP-14), whereas ocular HRQoL was assed using the Ocular Surface Disease Index (OSDI). Contingency table, Chi square test, t-test, Mann-Whitney test and Spearman9s rank correlation coefficient were employed for statistical analysis. <h3>Results</h3> 360 pSS patients (346 F:14 M) were included; mean age (S.D.) at diagnosis was 51 (14) yrs, mean age (S.D.) at study inclusion was 58 (15) yrs, mean disease duration (S.D.) was 6 (7) yrs. Out of 360 patients, 270 (75%) presented a low disease activity (ESSDAI&lt;5), 85 (23.6%) a moderate activity (5≤ESSDAI≤13) and 5 (1.4%) a high disease activity (ESSDAI≥14). A SSDDI≥2 was detected in 40.2% of the patients. The mean (S.D.) ESSPRI was 6.4 (2.3). Female patients and patients with a concomitant fibromyalgia presented significantly higher ESSPRI scores (total and single items).The ESSPRI correlated with age both at diagnosis and at study inclusion, with the disease duration and with the SSDDI, particularly the oral dryness measured by the corresponding ESSPRI item. No correlation was detected between the ESSPRI and the disease activity (ESSDAI) or the ESSPRI and patients9 immunological profile. A moderate correlation was observed between the ESSPRI, the OHIP and the OSDI, and between these two indexes and the oral and ocular damage, respectively. <h3>Conclusions</h3> We documented a significant correlation between the ESSPRI, patient demographics, disease duration and organ damage, but not with the disease activity and immunological pSS features. ESSPRI index demonstrated to be useful in assessing HRQoL associated with oral and ocular dryness in patients with pSS; however, a comorbid fibromyalgia may have an added effect on patient-reported outcomes and quality of life and should be taken into account in clinical practice. <h3>Disclosure of Interest</h3> None declared
OC-019 The evaluation of portal hypertension using quantitative magnetic resonance imaging (MRI)
Authors: N Palaniyappan, E Cox, IN Guha, A Austin, R O’Neill, G Ramjas, S Travis, H White, R Singh, P Thurley, S Francis, GP Aithal
Journal: Gut (2015)

<h3>Introduction</h3> The majority of complications in liver cirrhosis results from portal hypertension. The hepatic venous pressure gradient (HVPG) is the gold standard measure to assess portal pressure but this requires hepatic vein catheterisation which is an invasive procedure and available in only a few specialised liver units. We aim to develop a novel non-contrast quantitative MRI methodology to estimate portal pressure. <h3>Method</h3> We prospectively recruited patients undergoing HVPG measurement for clinical indications and MRI was performed within 6 weeks. A respiratory-triggered inversion recovery scheme was used to measure the longitudinal (T<sub>1</sub>) relaxation time of the liver and spleen employing a fat suppressed Echo Planar Imaging-acquisition. Phase-contrast (PC)-MRI was used to assess the velocity, area and bulk flow in the splanchnic circulation without any intravenous contrast agents. <h3>Results</h3> 33 patients [alcoholic, 10 (30.3%); non-alcoholic fatty liver disease, 11 (33.3%); and autoimmune hepatitis, 5 (15.2%)], aged 55 ± 12 years (mean ± SD) were enrolled in this study. 4 patients were excluded due to claustrophobia (3) and non-cirrhotic portal hypertension (1). Liver and spleen T<sub>1</sub>relaxation time correlated significantly with HVPG (R = 0.797, p &lt; 0.001; R = 0.383, p = 0.037 respectively) (Figure 1). The correlation of HVPG with splanchnic and collateral haemodynamics is shown in Table 1. <h3>Conclusion</h3> We have demonstrated that parameters related to both hepatic architecture and splanchnic haemodynamics derived from non-contrast quantitative MR imaging techniques correlate significantly with HVPG. In future studies, these MRI techniques will be utilised for the non-invasive evaluation of portal hypertension. <h3>Disclosure of interest</h3> None Declared.
FAMILIAL MEDITERRANEAN FEVER AND AMYLOIDOSIS
Authors: S Mairata Bosch, A Alarcón Zurita, M Dalmau Diana, J Bestard Palmer, C Pizá Buñola, A Morey Molina, J E Marco Franco
Journal: JAMA (1961)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lysosomal Enzymes in Pericellular Environment: A Factor in Tumor Regression?
Authors: Manfred von Ardenne
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Lysosomal Enzymes in Pericellular Environment: A Factor in Tumor Regression? Get access Manfred von Ardenne Manfred von Ardenne Forschungsinstitut Manfred von Ardenne 8051 Dresden, East Germany Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 1, July 1973, Pages 313–314, https://doi.org/10.1093/jnci/51.1.313 Published: 01 July 1973
Soundings: Medical heroes
Authors: Kevin Barraclough
Journal: BMJ (2003)

I suppose that, in the age of evidence based medicine, it is somewhat passe to have heroes. Nowadays we believe things in medicine only when there is evidence to do so. Non-medical friends are a little incredulous when I explain the emergence of this startling idea 300 years after the Enlightenment. They presume that all we had before this was prejudice based medicine. And maybe they're right. I remember the culture shock of a London teaching hospital with its aloof oligarchy of consultants. From the slightly shabby world of scientists chatting over coffee I entered a miasma of Savile Row suits, anachronistic servility, and unforgiving clinical failures. A decade later I welcomed the idea that evidence should replace authority.

But is “The Medical Authority” now extinct? I remember several types of this beast in the past. There was the bullying professor who would bellow at medical students about the critical importance of headache in people with acromegaly, or bark at the stupidity of the world at large in missing a case of Frohlich's syndrome. This would be the medical authority as bombast, and is not greatly mourned. It is nuclear physicist Edward Teller's definition of “expert”—someone who has made all possible errors in a very small field. They have lost touch with the world.

But there was another altogether more sympathetic figure—the repository of a wide clinical wisdom not available in books. This is the experienced clinician as hero. Their authority derives from experience and clarity of both thought and exposition.

I think anyone who has gasped for air in a darkened auditorium under the crushing weight of a mountain of PowerPoint bar charts will acknowledge that detail more often obscures truth than reveals it. The trouble with evidence based medicine is the sheer undigested bulk of it, and its relative crudity as an instrument for analysing something as complex as the practice of medicine. I still feel the need for medical heroes to guide me with simple conclusions, even though I know that that simplicity is the outcome of technical subtlety. But my heroes are active clinicians rather than experts on bar charts. For me, a single clinical aphorism is usually worth a thousand abstracts.

It is summed up in a quotation I have always ascribed, somewhat implausibly, to Yogi Bear: in theory there is no difference between theory and practice; in practice there is.
Induction of Tumors in Newborn Mice With Dibenz[&lt;italic&gt;a,h&lt;/italic&gt;]anthracene and 3-Methylcholanthrene
Authors: Kelly, Margaret G., O'Gara, Roger W.
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Induction of Tumors in Newborn Mice With Dibenz[a,h]anthracene and 3-Methylcholanthrene Get access Margaret G. Kelly, Margaret G. Kelly Pharmacology and Experimental Therapeutics Service, General Medicine Branch and Laboratory of Pathology, National Cancer Institute,4Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Roger W. O'Gara Roger W. O'Gara Pharmacology and Experimental Therapeutics Service, General Medicine Branch and Laboratory of Pathology, National Cancer Institute,4Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 26, Issue 3, March 1961, Pages 651–679, https://doi.org/10.1093/jnci/26.3.651 Published: 01 March 1961 Article history Received: 22 August 1960 Published: 01 March 1961
THU0022 Single Cell Interferon Signatures in Lupus Patient Monocytes Reveal a Differential Impact of Interferon Signaling Between Monocyte Subtypes
Authors: Z. Jin, W. Fan, M.A. Jensen, J.M. Dorschner, D.M. Vsetecka, S. Amin, A. Makol, F. Ernste, T. Osborn, K. Moder, V. Chowdhary, T.B. Niewold
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Type I interferon (IFN) is a primary pathogenic factor in human systemic lupus erythematosus (SLE). IFN signatures have been observed in immune cell populations. <h3>Objectives</h3> We examined gene expression in individual monocytes from SLE patients in this study. <h3>Methods</h3> CD14++CD16- classical monocytes (CLs) and CD14dimCD16+ non classical monocytes (NCLs) from SLE patients were purified by magnetic separation. The Fluidigm C1 System was used for single cell capture and target gene pre-amplification. Rt-PCR was used to quantify expression of 87 monocyte-related genes. An individual cell IFN score was generated based upon the expression of 17 IFN-induced genes. <h3>Results</h3> Monocytes from the same SLE patient blood sample demonstrated varying levels of IFN-induced gene expression. In CLs, high IFN score correlated with CD32a, IL1B, and IL8 expression. In NCLs, high IFN score was correlated with inflammatory mediators, including cytokines such as IL12, IL23, and IL15; the immune receptors CD36, CD32a, CD80, and TLR7; and inflammatory signaling genes such as RELA, STAT2, IRAK1, and MyD88. CD16 transcripts were detected in a small group of classical monocytes, despite a lack of surface CD16 expression. In these cells, CD16 expression was positively correlated with IFN score (p=0.019). <h3>Conclusions</h3> This study reveals diverse IFN responses of individual monocytes, supports the idea that IFN signaling has distinct effects upon classical and non-classical monocytes. IFN may contribute to the transition from classical to non-classical subtype in SLE. Single cell studies can reveal effects of IFN on single immune cells which may be masked in whole blood or mixed cell populations. <h3>Disclosure of Interest</h3> None declared
OC-085 Endoanal ultrasound findings and corresponding cleveland clinic faecal incontinence scores following a third or fourth degree perineal tear
Authors: G Thomas, F Casunuran, D Kumar
Journal: Gut (2015)

<h3>Introduction</h3> Third and fourth degree perineal tears will occur in a small proportion of vaginal deliveries. When found at the time of delivery, they are typically repaired primarily. Patients may subsequently suffer from faecal incontinence. <h3>Method</h3> All patients with a third and fourth degree tear were referred for assessment. This included endoanal ultrasonography and estimation of incontinence with the Cleveland Clinic faecal incontinence score. Data from 2001 to 2013 were analysed. <h3>Results</h3> 888 patients were included. Of these, 551 (62%) were found to have a sphincter defect. 333 (38%) had intact sphincters. The majority of these had normal looking sphincters on ultrasonography. The mean (SD) incontinence score for those with a defect was 4.3 (5.5). The mean incontinence score for those with no defect was 4.2 (5.8). <h3>Conclusion</h3> The majority of patients had a sphincter defect. This suggests that there is a high failure rate from the primary repair. The high proportion of normal looking sphincters suggests that third and fourth degree tears may be over diagnosed. Despite the ultrasound findings, the incontinence scores for both groups were comparable. <h3>Disclosure of interest</h3> None Declared.
High Incidences of Pheochromocytomas After Long-Term Administration of Retinol Acetate to F344/DuCrj Rats&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Y Kurokawa, Y Hayashi, A Maekawa, M Takahashi, T Kukubo
Journal: JNCI Journal of the National Cancer Institute (1985)

The carcinogenicity of retinol acetate [(RAC) CAS: 127-47-9], a synthetic derivative of retinol, was tested by continuous oral administration in the drinking water of F344/DuCrj rats for 104 weeks. Groups of 50 male and 50 female rats were given solutions of 0.25 or 0.125% RAC in the form of gelatinized beadlets suspended in distilled water. Control groups consisting of the same numbers of rats were given 0.25% of placebo beadlets. All of the surviving animals were killed at 108 weeks, 4 weeks after the cessation of the RAC treatments. The survival rates were 72-84% and were sufficiently high for statistical comparison of all groups. Inhibition of body weight gain was marked in females of the high-dose group. Higher incidences of malignant pheochromocytomas, benign pheochromocytomas, and hyperplasias of the adrenal medulla were observed in the RAC-treated groups. The combined incidences of tumors of the adrenal medulla in males and females of the high-dose groups and the incidence in females of the low-dose group were significantly higher than the incidence in the controls. Conversely, statistically significant decreases were found in the incidences of the mammary gland tumors in males of the high-dose group, of thyroid tumors in females of the high-dose group, and of clitoral gland tumors in females of both high- and low-dose groups. It was concluded that RAC given orally possesses potential for increasing the incidence of pheochromocytomas in male and female F344 rats in a dose-related manner under the conditions of this bioassay.