tbuckley/cabot-search huggingface dataset:
VENEREAL SPIROCHETOSIS OF RABBITS
Authors: J P NEWMAN
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Hepatocarcinoma and the Comparative Embryology of the Vertebrate Liver&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;, &lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Hans Elias
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Human Hepatocarcinoma and the Comparative Embryology of the Vertebrate Liver, Get access Hans Elias Hans Elias Department of Anatomy, The Chicago Medical School, and Hektoen Institute for Medical Research and Department of Pathology, Cook County Hospital, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue Supplement_5, April 1955, Pages 1451–1462, https://doi.org/10.1093/jnci/15.Supplement_5.1451 Published: 01 April 1955
THU0547 Evaluation of Venous Disease Spesific Quality of Life in Patients with Vascular Behçet's Disease: Table 1.
Authors: F. Alibaz-Oner, B. Aldag, M. Aldag, A.U. Unal, T. Toptas, T. Ergun, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Vascular involvement especially in young males and is one of the major causes of mortality and morbidity. Lower extremity deep vein thrombosis (DVT) is the most frequent form of vascular involvement. Chronic post-thrombotic syndrome develops in up to one-half of patients with deep venous thrombosis. Patients with post-thrombotic syndrome have substantially impaired quality of life. <h3>Objectives</h3> There is no data about post-thrombotic syndrome in deep venous thrombosis associated with Behçet9s Disease. In this study,we aimed to evaluate venous disease spesific quality of life in patients with Vascular Behçet9s Disease (VBD). <h3>Methods</h3> In this study, 62 patients (Male/Female: 47/15, mean age: 38.6±9.2 years) with VBD, who were regularly followed in Marmara University Behçet clinic, 29 patients (Male/Female: 20/9, mean age: 41.6±11.8 years) with DVT associated with non-BD reasons, who were followed in Hematology and Vascular Surgery Department, were assessed. Venous Disability Score (VDS) and Venous Clinical Severity Score (VCSS) were used to evaluate the severity of venous insufficiency. Venous disease-specific quality of life (the primary outcome) was measured using the Turkish validated form of Venous Insufficiency Epidemiological and Economic Study Quality of Life/Symptom questionnaire (VEINES-QoL/Sym). After calculation, VEINES-QoL and VEINES-Sym sub-score were identified. Higher score shows better QoL. Short Form (SF-36) and Behçet Syndrom Activity Score (BSAS) questionnaire were also fullfilled to patients. <h3>Results</h3> Physical and mental component of SF-36 were similar between VBD and non-BD group. VCSS and VDS were significantly worse in non-BD group compared to VBD. VEINES-QoL and VEINES-Sym were significantly better in VBD group (Table 1). Mean duration after DVT was 6.7±5 years in VBD, 1.6±1 years in non-BD group. There was no correlation between VEINES-QoL, VEINES-Sym score and duration after DVT, daily sitting and standing time. But VEINES-QoL and VEINES-Sym negatively correlated with VCSS (respectively; r: -0.367, p&lt;0.001, r:-0.384, p&lt;0.001) and VDS (respectively, r: -0.288, p=0.007, r:-0.265, p=0.013). VEINES-Sym and VEINES-QoL also significantly correlated with BSAS (respectively, r: -0.526, p&lt;0.001 ve r:-0.496, p&lt;0.001). <h3>Conclusions</h3> In our study, we found that venous spesific QoL and symptoms worsen together with increasing VDS and VCSS score. These results suggest that controlling of disease activity increase the OoL as well as preventing the relapses. <h3>Disclosure of Interest</h3> None declared
The Effect of Subcutaneous Inoculation of 4-&lt;italic&gt;o&lt;/italic&gt;-Tolylazo-&lt;italic&gt;o&lt;/italic&gt;-Toluidine in Strain HR Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Margaret K. Deringer
Journal: JNCI Journal of the National Cancer Institute (1956)

The Effect of Subcutaneous Inoculation of 4-o-Tolylazo-o-Toluidine in Strain HR Mice Margaret K. Deringer Margaret K. Deringer National Cancer Institute,4Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 4, October 1956, Pages 533–539, https://doi.org/10.1093/jnci/17.4.533 Published: 01 October 1956 Article history Received: 09 July 1956 Published: 01 October 1956
PRIMARY URETERAL CARCINOMA
Authors: A Musierowicz, A Litwak
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0719 Three Cases of Anti-TNF Induced Myositis and Literature Review
Authors: O. Zengin, S. Alkan, G. Kimyon, N. Hüseynova, B. Kısacık, A.M. Onat
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Anti-tumor necrosis factor (anti-TNF) drugs are frequently preferred in the treatment of rheumatologic diseases and other inflammatory diseases (1). The development of myositis after using anti-TNF is a rare clinical condition. <h3>Objectives</h3> To report cases followed up who developed myositis after using anti-TNF. To review the current literature Anti-TNF Induced Myositis. <h3>Methods</h3> <i>Case 1:</i> A 30-year-old male patient had been followed-up with the diagnosis of AS for ten years. The patient had taken a total of 20 (2.5 months) doses of etanercept treatment and the patient had complaints of weakness, fatigue, difficulty in climbing the stairs and sitting within the last three weeks. Creatinine kinase (CK) was 6035 U/L. The deltoid muscle biopsy was consistent with polymyositis. <i>Case 2:</i> A 20-year-old female patient had been followed-up with the diagnosis of RA for two years. Following adalimumab treatment, the complaints related to joints completely had regressed and in the sixth month of treatment, the patient had the complaints of weakness, fatigue, which had gradually increased within the last two weeks. CK was 4772 U/L. The deltoid muscle biopsy was consistent with myositis. <i>Case 3:</i> A 44-year-old female had been followed-up with the diagnosis of RA for approximately seven years. Following adalimumab treatment, all complaints related to the joints had decreased. However, the patient had had the complaints of eruption in the arms, forehead, and around the nose, on the metacarpopharyngeal joints of hand, fatigue, difficulty in climbing the stairs, sitting, and dyspnea, which increased with effort within last four weeks. CK was 1563 U/L. Muscle biopsy were consistent with dermatomyositis. <h3>Results</h3> In the literature, six cases of inflammatory myositis related to anti-TNF treatment have been reported (2-7). PM (polymyositis, 6) developed in the majority of the patients and DM (dermatomyositis, 3) developed in the minority. The cases in the literature in which myositis developed following anti-TNF use were summarized in Table 1. <h3>Conclusions</h3> In conclusion, myositis could develop during anti-TNF therapy. Especially in patients diagnosed with RA and who are anti jo-1 positive, more care should be taken in this aspect. In these cases anti-TNF therapy could be the triggering factors for myositis and interstitial fibrosis. <h3>References</h3> Reimold AM. New indications for treatment of chronic inflammation by TNF-alpha blockade. Am J Med Sci 2003;325:75-92. Ishikawa Y, Yukawa N, Ohmura K, Hosono Y, Imura Y, Kawabata D, Nojima T, Fujii T, Usui T, Mimori T. Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis: a case report and review of the literature. Clin Rheumatol. 2010 May;29(5):563-6. doi: 10.1007/s10067-009-1370-1. Epub 2010 Feb 9. <h3>Disclosure of Interest</h3> None declared
John Locke's Medical Notes
Authors: P LASLETT
Journal: BMJ (1964)

BRITISH of an increasing level of serum cholesterol ?Isn't essential hypercholesterolaemia a defect in this mechanism ?Dr. LEWIS: Yes, that has been suggested.Dr. PALLIS: What is the evidence for this ?Dr. LEWIS: I don't think this hypothesis has been studied.But there is another feedback mechanism by which cholesterol synthesis and breakdown are modified by the quantity and per- haps the nature of bile acids reabsorbed from the intestine.These processes may prove to be of major importance.Dr. COPE: There is one odd point as we end.I have been trying to read a bit about this subject, and a lot of queer facts emerge.For instance, serum cholesterol has been proved to rise significantly
Consistency Of RQ-PCR Analysis Results In Peripheral Blood and Bone Marrow Samples In Chronic Myeloid Leukemia Patients: Relevance From The Practical and Logistic Point Of View
Authors: Giovanna Rege-Cambrin, Carmen Fava, Enrico Gottardi, Filomena Daraio, Emilia Giugliano, Francesca Crasto, Roberta Lorenzatti, Alessandro Volpengo, Bruno Di Gioacchino, Giuseppe Saglio
Journal: Blood (2013)
Nationwide outbreak of Salmonella serotype Kedougou associated with infant formula, Spain, 2008
Authors: J Rodríguez-Urrego, S Herrera-León, A Echeita-Sarriondia, P Soler, F Simon, S Mateo, Collective Investigation team
Journal: Eurosurveillance (2010)

On 5 August 2008, the National Centre of Microbiology in Madrid, Spain, notified an increase in Salmonella Kedougou isolations compared to 2007, with 21 cases including 19 children under one year of age. Active case finding and a matched case-control study were carried out to confirm this increase, identify source, transmission mode and risk factors in order to implement control measures. Cases were defined as any child under one year of age with S. Kedougou isolated since 1 January 2008, and were matched for age, sex, medical practitioner and diagnosis week with controls who were selected among patients of the cases' medical practitioners. An ad hoc questionnaire was completed for cases and controls and a univariate analysis was conducted to identify risk factors. We found 42 isolates from 11 of the 19 Spanish Regions. Completed questionnaires were available for 39 of 42 patients identified; 31 were children under one year of age and fulfilled the case definition. The median age of the 31 cases was 4.3 months and 13 were male. Main symptoms were diarrhoea (n=31) and fever (n=13). Ten cases required hospitalisation. All 31 cases had consumed infant formula milk of Brand A which was associated with illness in the univariate analysis (exact matched odds ratio: 74.92; 95% confidence interval: 12.89-∞). All patient isolates showed indistinguishable pulsed-field gel electrophoresis and antimicrobial susceptibility patterns. Five milk samples from three cases' households were negative for Salmonella. Our results suggest that Brand A was the transmission vehicle of S. Kedougou in the outbreak that occurred in Spain between January and August 2008. Food safety authorities recalled five batches of Brand A milk on 26 August 2008. No further cases have been detected as of 15 September 2009.
OP0295 Mice Lacking Bob1 Exclusively in B Cells are Resistant to Type II Collagen-Induced Arthritis
Authors: M. Levels, M. van Tok, T. Cantaert, D. Baeten, N. Yeremenko
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Despite growing insights in the breach of immune tolerance, it remains currently unknown which molecules drive or control pathogenic B cells in human rheumatoid arthritis (RA). Recently we have identified a marked increase in expression of the B cell-specific transcriptional co-activator Bob1 in RA synovitis. Additionally, we found that mice lacking Bob1 failed to produce pathogenic anti-collagen autoantibodies and were completely protected from collagen-induced arthritis (CIA), the animal model of RA. <h3>Objectives</h3> We aimed to determine whether this remarkable resistance to CIA in the absence of Bob1 is caused due to lack of functional germinal centers or by intrinsic defects in the B cells of these animals. Furthermore we proceeded to prove that the resistance to CIA is caused exclusively by B cells lacking Bob1. <h3>Methods</h3> First, to determine whether intrinsic B cell defects were the basis of the CIA resistance, we transferred wild type (WT) B cells to Bob1-deficient mice, lacking functional germinal centers (GC), followed by CIA. Then, in order to prove that functional Bob1 exclusively in B cells is required for susceptibility to CIA, we adoptively transferred various combinations of WT and Bob1-deficient B and T cells to RAG-1-<i>null</i> mice followed by CIA induction. <h3>Results</h3> After transfer of WT cells to Bob1-deficient animals, Bob1-deficient mice were still resistant to CIA, suggesting that resistance to CIA is related to GC formation rather to intrinsic B cells defects in the absence of Bob1 and that GCs are important in the pathogenesis of CIA. In the RAG-1-<i>null</i> adoptive transfer model we only observed clinical symptoms of arthritis in the mice that received WT B cells. Moreover, anti-collagen antibodies were only found in the serum of mice that had received WT B cells. Mice lacking Bob1 in their transferred B cells were still protected from CIA. <h3>Conclusions</h3> This data strongly suggest that expression of Bob1 in B cells is indispensable for GC formation and required for the development of CIA and the formation of anti-collagen antibodies. The mechanisms behind an aberrant Bob1 expression and the break of peripheral tolerance in RA is currently under investigation. <h3>Disclosure of Interest</h3> None declared
Three patients with concomitant panic attacks and seizure disorder: possible clues to the neurology of anxiety
Authors: J B Weilburg, D M Bear, G Sachs
Journal: American Journal of Psychiatry (1987)

The authors present the cases of three patients in whom panic attacks and epilepsy appeared together. These cases illustrate various possible relationships between panic attacks and epilepsy. These relationships include panic attacks representing the aura of a complex partial seizure, panic attacks representing a manifestation of interictal behavior change, and panic attacks and seizure coexisting independently. The authors conclude that exploration of the mechanisms operating in unusual cases like these may provide a vehicle for clarifying the neurobiological basis of anxiety.
Sentinel Surveillance: an option for surveillance of infectious intestinal disease
Authors: C Gauci, T Melillo Fenech, H Gilles, S O'Brien, I Stabile, N Calleja, F Ruggeri, L Cuschieri, J Mamo
Journal: Eurosurveillance (2007)

Sentinel surveillance systems offer advantages over passive surveillance which is known to have limitations due to incomplete reporting. Sentinel surveillance gathering data from selected sources was piloted as an option for surveillance of infectious intestinal disease (IID) in Malta. Between October 2004 and May 2005, 22 general practitioners (GPs) voluntarily participated in the study and reported on the number of IID cases (by age and sex) and all primary care encounters in their practice. The GPs' reporting activity lasted for 35 weeks, covering a total of 55,425 primary care encounters, of which 1.95% concerned IID. For every case reported via the routine passive notification system, seven cases would be picked up by this enhanced sentinel surveillance.
Comment on “Effects of Arsenite during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Diseases in Male Mice” and “Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Trends and Scientific Gaps”
Authors: Paul A. Fowler, Amanda J. Drake, Peter J. O’Shaughnessy, Siladitya Bhattacharya, Andrea Raab, Kevin D. Sinclair, Jörg Feldmann, Andrew A. Meharg
Journal: Environmental Health Perspectives (2016)
AB0906 Osteoporosis: An Important Matter for Consideration in Liver Cirrhosis
Authors: S. Belghali, H. Senda, K. Baccouche, H. Zeglaoui, E. Bouajina, A. Jemaa
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Bone metabolism abnormalities observed in liver cirrhosis are refered to as hepatic osteodystrophy. Osteodystrophy consists of osteoporosis and or osteomalacia<sup>1,2</sup>. Our study investigated the prevalence of osteoporosis in fifty patients with liver cirrhosis and searched determinant factors of bone loss. <h3>Methods</h3> Fifty patients (29 females and 21 males, mean age 55 years) with liver cirrhosis were enrolled in this study. The bone mineral density (BMD) was evaluated by dual energy x ray absorptiometry of the lumbar spine (L1-L4) and total hip. A detailed questionnaire was used to assess: risk factors of osteoporosis and characteristics of the cirrhotic disease (such as etiology, child-pugh stage, complications, meld score and blood samples…). Univariate analysis was used to determine correlation with low BMD. <h3>Results</h3> A low BMD was finding in 37 patients (74%), 25 females and 12 males. Osteoporosis (TScore≤-2,5) was noted in 20 (40%) and osteopenia (-2.5 &lt; TScore ≤ -1) in 17 (34%) patients. Mean BMD was 0.980±0.17g/cm<sup>2</sup> in lumbar spine and 0.900±0.32g/cm<sup>2</sup> in total hip. Ten patients have sustained osteoporotic fracture. Etiology of cirrhosis was chronic viral hepatitis (48%), primary biliary cirrhosis (20%), primary sclerosing cholangitis (6%) and autoimmune hepatitis (4%). The cause was indeterminate in 10% of patients. In univariate analysis, a positive correlation with low BMD was noted with an age≥50 years (p=0.021), female sex (p=0.021), previous osteoporotic fracture (p=0.034), more than two complications of the cirrhotic disease (p=0.024), child-pugh stage B and C (p=0.006) and low albumin level (p=0.02). <h3>Conclusions</h3> The prevalence of osteoporosis in our study (40%) is concordant with literature data (20 to 56%)<sup>3,4</sup>. Determinant factors of low body mass were an age≥50, female sex, previous osteoporotic fracture, more than two complications of the cirrhotic disease, child-pugh stage B and C and low albumin level. The limits of our study were mainly the low effectif and the absence of a control group. <h3>References</h3> Long RG, Meinhard E, Skinner RK, Varghese Z, Wills MR, Sherlock S. Clinical, biochemical, and histological studies of osteomalacia, osteoporosis, and parathyroid function in chronic liver disease. Gut 1978:19(2):85-90. Long RG, Wills MR. Hepatic osteodystrophy. Br J Hosp Med. 1978; 20(3):312-21. Goral V, Simsek M, Mete N. hepatic ostéodystrophie and liver cirrhosis. World J Gastroenterol 2010; 16:1639-1643. German Lopez-Larramona, Alfredo J Lucendo, Sonia Gonzalez-Castillo, Jose M Tenias. Hepatic ostéodystrophie: An important matter for consideration in chronic liver disease. World J Hepatol 2011; 3 (12):300-307. <h3>Disclosure of Interest</h3> None declared
Comparative Analysis of the Host Response to Community-acquired and Hospital-acquired Pneumonia in Critically Ill Patients
Authors: Lonneke A. van Vught, Brendon P. Scicluna, Maryse A. Wiewel, Arie J. Hoogendijk, Peter M. C. Klein Klouwenberg, Marek Franitza, Mohammad R. Toliat, Peter Nürnberg, Olaf L. Cremer, Janneke Horn, Marcus J. Schultz, Marc M. J. Bonten, Tom van der Poll
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Preclinical studies suggest that hospitalized patients are susceptible to infections caused by nosocomial respiratory pathogens at least in part because of immune suppression caused by the condition for which they were admitted.We aimed to characterize the systemic host response in hospital-acquired pneumonia (HAP) when compared with community-acquired pneumonia (CAP).We performed a prospective study in two intensive care units (ICUs) in 453 patients with HAP (n = 222) or CAP (n = 231). Immune responses were determined on ICU admission by measuring 19 plasma biomarkers reflecting organ systems implicated in infection pathogenesis (in 192 patients with HAP and 183 patients with CAP) and by applying genome-wide blood gene expression profiling (in 111 patients with HAP and 110 patients with CAP).Patients with HAP and CAP presented with similar disease severities and mortality rates did not differ up to 1 year after admission. Plasma proteome analysis revealed largely similar responses, including systemic inflammatory and cytokine responses, and activation of coagulation and the vascular endothelium. The blood leukocyte genomic response was greater than 75% common in patients with HAP and CAP, comprising proinflammatory, antiinflammatory, T-cell signaling, and metabolic pathway gene sets. Patients with HAP showed overexpression of genes involved in cell-cell junction remodeling, adhesion, and diapedesis, which corresponded with lower plasma levels of matrix metalloproteinase-8 and soluble E-selectin. In addition, patients with HAP demonstrated underexpression of a type-I interferon signaling gene signature.Patients with HAP and CAP present with a largely similar host response at ICU admission.