tbuckley/cabot-search huggingface dataset:
Abstract 1192: Glutamic acid and glutaminolysis mark aggressive tumorigenesis in head and neck squamous cell carcinoma
Authors: Adam D. Banda, Mercedes Bermudez Cortes, Pachiyappan Kamarajan, Thekkenlnaycke Rajendiran, Arul M. Chinnaiyan, Yvonne L. Kapila
Journal: Cancer Research (2015)

Abstract The purpose of this study was to identify markers of aggressive tumor behavior to inform processes underlying tumor aggressivity in head and neck squamous cell carcinoma (HNSCC). To this end, metabolomic profiling and validation of biomarkers of aggressive HNSCC tumorigenesis were assessed in HNSCC human specimens and cell lines. Using LG/GC-MS, we found that glutamic acid is one of the most highly differentially elevated metabolites in HNSCC specimens. In subsequent validation studies, where we incorporated metastatic tissues, glutamic acid was further verified as differentially elevated in metastatic tissues compared to primary HNSCC and normal adjacent tissues. In addition, significantly elevated expression levels of c-Myc and glutaminase, the enzyme that regulates glutamic acid levels, were highest in metastatic tissues compared to primary HNSCC and normal tissues. Parallel changes in c-Myc and glutaminase expression in HNSCC tissues suggest a link between c-Myc regulation and glutamine metabolism. Furthermore, Western Blot analyses show similar expression patterns for c-Myc and glutaminase in oral cancer cell lines. Inhibiting glutamic acid levels by stably suppressing glutaminase expression in HNSCC cells, led to suppression of aggressive tumorigenesis in vitro, whereas enrichment with external glutamine or glutamic acid further enhanced tumorigenesis. Together, this data suggest that oncogenic levels of c-Myc may induce a transcriptional program that promotes elevated levels of glutamic acid and glutaminolysis via glutaminase to promote tumor aggressivity in head and neck cancer. Citation Format: Adam D. Banda, Mercedes Bermudez Cortes, Pachiyappan Kamarajan, Thekkenlnaycke Rajendiran, Arul M. Chinnaiyan, Yvonne L. Kapila. Glutamic acid and glutaminolysis mark aggressive tumorigenesis in head and neck squamous cell carcinoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1192. doi:10.1158/1538-7445.AM2015-1192
OP09THE EARLY IMPACT OF AN INNOVATIVE MULTIDISCIPLINARY TEAM TO NEURO-REHABILITATION FOR CHILDREN WITH A BRAIN TUMOUR
Authors: Emily Bennett, Jane Williams, Darren Reynolds, Laura Kelly, Rachel Keetley, Sophie Thomas
Journal: Neuro-Oncology (2015)

INTRODUCTION: An innovative multidisciplinary team approach to paediatric neuro-oncology and acquired brain injury (ABI) rehabilitation was created, aiming to decrease inpatient stays and improve early-supported discharge. METHOD: A new MDT was created at a regional centre, providing early assessment, intervention and integrated discharge planning for children requiring neuro-rehabilitation after a brain tumour (BT) or ABI. The team works alongside existing neuro-oncology services, with a specific aim of speeding up supported-discharge, decreasing extended stays for therapy, and providing specialist outreach to children, families and community services. Data on length of hospital stay for children receiving neuro-rehabilitation before and after the team's formation was collected to consider the team's impact. Outcome and satisfaction data are also collected. RESULTS: Prior to the team's formation, 2011-12 data indicated 43 children received hospital-based neuro-rehabilitation. 17 were children diagnosed with a BT. Due to inequitable community provision, many children remained as inpatients, with an average length of stay of 63 days for neuro-oncology patients. In the four months since formation, seven children diagnosed with a BT have had care from the new team. This has led to a reduction in mean length of hospital stay to 15 days. Additional outcome data highlights improved specialist support for transitions home, into local services and education. Families report high satisfaction and improved quality of life as a result of this specialist support. CONCLUSION: Positive findings demonstrate the impact of early care planning and specialist outreach, in reducing hospital stays for children with a BT.
Human Brain Endothelial Cells (HUBEC) Can Expand Both Human Bone Marrow and Cord Blood SCID-Repopulating Cells (SRC) through Cell Contact Rather Than Soluble Factors.
Authors: Naoko Takebe, Xiangfei Cheng, Ann M. Farese, Emily Welty, Barry Meisenberg, Thomas MacVittie
Journal: Blood (2005)
Molecular profiling as a possible prognostic marker for patients with cancer of unknown primary treated using platinum doublet chemotherapy.
Authors: K. Hashimoto, Y. Sasajima, M. Ando, K. Yonemori, A. Hirakawa, H. Tsuda, Y. Fujiwara
Journal: Journal of Clinical Oncology (2011)

e21040 Background: Platinum doublet chemotherapy regimens (PD) are considered standard treatment for cancer of unknown primary (CUP). In this study, we assessed whether molecular profiling (MP) could predict the prognosis of patients (pts) who had CUP and were treated using PD. Methods: This retrospective study involved 71 pts who were diagnosed as having CUP adenocarcinoma, were treated using PD, and whose tissue samples were available between 1997 and 2008. We excluded favorable subsets of CUP; female pts with elevated CA125 levels, male pts with elevated PSA levels, female pts with metastasis only in the axillary lymph nodes. We constructed an MP panel by using immunohistochemistry (IHC) and PCR results. This panel included the following biomarkers for identifying the origin of CUP: CK 7, CK 17, CK 19, CK 20, CDX-2, WT1, PAX8, TTF1, mammaglobin, GCDFP, PSA, uroplakin, (all by IHC) and K-ras mutation (by PCR). We also assessed EGFR and K-ras mutations that had been identified using MP for the lung cancer and colorectal cancer profiles. Results: Of the 71 pts, a primary tumor site profile was identified for 58 pts (81.7%): lung (N = 17), colorectum (N = 13), ovary (N = 9), prostate (N = 7), liver/kidney (N = 6), breast (N = 4), and bladder (N = 2); the primary tumor site was undetermined in the remaining pts (UND) (N = 13). Progression-free survival (PFS) and overall survival (OS) for the different sites were determined by MP: lung, 6.8 and 17.4 months (m); colorectum, 4.8 and 13.8 m; ovary, 11.2 and 23.3 m; prostate, 11.0 and 18.0 m; liver/kidney, 3.0 and 6.6 m; breast, 4.5 and 8.2 m; bladder, 2.7 and 5.0 m; and UND, 4.9 and 10.0 m, respectively. Multivariate analysis revealed PFS and OS were significantly varied depending on these tumor groups (p = 0.049 and p = 0.008). The pts with prostate, colon, breast, ovary, or lung cancer profiles were identified as having longer OS than did the pts with the other profiles (p = 0.025, p = 0.014, p = 0.015, p < 0.001, p = 0.005, respectively). We identified 3 of 13 K-ras mutations for the colorectal cancer profile and 1 of 17 EGFR mutations for the lung cancer profile. Conclusions: MP is a simple method and may be able to predict the prognosis of pts with CUP treated using PD.
Rituximab as Adjuvant to Dose-Dense and High Dose Chemotherapy (HDC) with Autologous Stem Cell Transplantation (ASCT) as First Line Treatment in Stage III–IV Diffuse Large B-Cell Lymphoma (DLBCL) at Poor Prognosis: Final Analysis of Phase II GIMURELL Trial.
Authors: Umberto Vitolo, Maria Giuseppina Cabras, Giuseppe Rossi, Anna Marina Liberati, Annalisa Chiappella, Alessandro Levis, Vincenzo Pavone, Emanuele Angelucci, Barbara Botto, Giovannino Ciccone, Roberto Freilone, Gianluca Gaidano, Domenico Novero, Isabella Palumbo, Enrico Maria Pogliani, Patrizia Pregno, Delia Rota Scalabrini, Flavia Salvi, Anna Tonso, Alessandra Tucci, Eugenio Gallo
Journal: Blood (2006)
EFICACIA Y COSTE DE LA TECNICA RENDEZ-VOUS RADIOLOGICO ANTE EL FRACASO DE CPRE
Authors: F Pérez Roldán, P González Carro, J González-Spinola San Gil, E Tebar Romero, P Reales Figueroa, E Romero Rodríguez, P Peña Martinez, L Legaz Huidobro María, O Roncero García-Escribano, S Aoufi Rabih
Journal: Endoscopy (2015)

Introducción: Cuando fracasa la canulación mediante CPRE, hay varias alternativas entre las que se encuentran la colangiografia percutánea transhepática, acceso biliar mediante ecoendoscopia o combinación con CPRE.
Tyk2 Mutation Homologous to V617F Jak2 Is Not Found in Essential Thrombocythaemia, Although It Induces Constitutive Signaling and Growth Factor Independence.
Authors: Kotaro Shide, Kazuya Shimoda, Kenjirou Kamezaki, Haruko Kakumitsu, Takashi Kumano, Seido Oku, Akihiko Numata, Fumihiko Ishikawa, Katsuto Takenaka, Mine Harada
Journal: Blood (2006)
Abstract 2151: Fragmented QRS in Body Surface Potential Mapping Predicts Cardiac Death and Hospitalizations after Myocardial Infarction
Authors: Petri Korhonen, Teijo Konttila, Terhi Husa, Ilkka Tierala, Markku Mäkijärvi, Heikki Väänänen, Lauri Toivonen
Journal: Circulation (2008)

Increased QRS fragmentation in visual inspection of 12-lead ECG has shown association with cardiac events in post-myocardial infarction (MI) patients. We investigated if user-independent computerized intra-QRS fragmentation analysis predicts cardiac deaths (CD) and heart failure hospitalizations (HFH) after acute MI. Patients (n= 158) with acute MI and left ventricular ejection fraction (LVEF) &lt; 50% were studied. Mean age was 61±10 years and left ventricular ejection fraction 40 ± 6%. A 120-lead body surface potential mapping was performed at hospital discharge. After signal-averaging and binomial filtering QRS fragmentation was computed as the number of extrema within the whole QRS (fragmentation index M). QRS duration (QRSd) was computed for comparison. During a mean follow-up of 51 months 15 patients suffered cardiac death and 23 were hospitalized for HF. Both M and QRSd were significantly larger in patients with events. Using the mean value + 1SD as cut-point both parameters were univariate predictors of CD and HFH. In multivariate analysis including age, sex, LVEF, bundle branch block, previous MI, atrial fibrillation, and diabetes M was an independent predictor for cardiac death and HFH (HR 8.7 for CD and 3.8 for HFH) whereas QRSd only predicted HFH (HR 4.6). M showed adequate positive (PPA) and excellent negative (NPA) predictive accuracy, which were further improved when combined to LVEF &lt; 40% (Table ). Increased QRS fragmentation in post-infarction patients predicts cardiac deaths and progression of heart failure. A computer-based automatic fragmentation analysis is a stronger predictor than QRS prolongation.
Lens Power, Axial Length-to-Corneal Radius Ratio, and Association with Diabetic Retinopathy in the Adult Population with Type 2 Diabetes
Authors: Jiangnan He, Xian Xu, Jianfeng Zhu, Bijun Zhu, Bo Zhang, Lina Lu, Xiangui He, Xuelin Bai, Xun Xu, Haidong Zou
Journal: Ophthalmology (2016)
Treatment with the Terminal Complement Inhibitor Eculizumab Improves Anemia in Patients with Paroxysmal Nocturnal Hemoglobinuria: Phase III Triumph Study Results.
Authors: Jörg Schubert, Peter Hillmen, Ulrich Dührsen, Neal S. Young, Modupe Elebute, Jeffrey Szer, Giacomo Gianfaldoni, Gérard Socié, Paul Browne, Christopher F. Mojcik, Russell P. Rother, Petra Muus
Journal: Blood (2006)
Abstract 1445: Overexpression of angiotensin II type 1 receptor induces epithelial-mesenchymal transition and promotes tumorigenesis of human breast cancer cells
Authors: Eunhye Oh, Ji Young Kim, Youngkwan Cho, Nahyun Lee, Hyunsook An, Jun Suk Kim, Jae Hong Seo
Journal: Cancer Research (2015)

Abstract Propose: Accumulating evidence suggests that angiotensin II type 1 receptor (AGTR1) is involved in tumorigenesis and metastasis in many types of cancer, however little is known about its role in breast cancer. Our objective of the present study is to investigate the effect of AGTR1 overexpression on cell proliferation, epithelial-mesenchymal transition (EMT), migration, invasion, angiogenesis and tumorigenesis of human breast cancer. Methods: To determine the role of AGTR1, MCF7 cells were stably transfected with an expression construct carrying the GFP cDNA for AGTR1. MTS assay, Matrigel invasion assay, wound healing assay, Western blotting and immunofluorescence were used. For in vivo study, parental MCF7 or AGTR1-MCF7 cells were subcutaneously injected into the left and right flanks of nude mice. Tumor growth and angiogenesis were determined. Results and conclusion: AGTR1-MCF7 cells, expressing high level of AGTR1 exhibited significant increases in cell proliferation, migration and invasion capacities compared with parental MCF7 cells. Furthermore, AGTR1-MCF7 cells displayed the mesenchymal phenotype, as evidenced by elongated spindle morphology, decreased E-cadherin level, increased N-cadherin and snail, and nuclear accumulation of smad3 and smad4. Interestingly, blockade of smad4 using small interfering RNA strongly induced mesenchymal to epithelial transition (MET) and restoration of E-cadherin expression in AGTR1-MCF7 cells, suggesting that AGTR1-induced EMT is ultimately mediated by smad4 activation. Finally, we showed that AGTR1 overexpression enhanced tumor volume (p&amp;lt;0.001, n = 10) and weight (p&amp;lt;0.01) as well as increased angiogenesis in human breast cancer xenograft in vivo. In summary, we demonstrate that AGTR1 overexpression promotes cell proliferation, EMT, angiogenesis and tumorigenic properties of breast cancer cells. Our findings suggest that AGTR1 could be a useful target of therapy in breast cancer. Citation Format: Eunhye Oh, Ji Young Kim, Youngkwan Cho, Nahyun Lee, Hyunsook An, Jun Suk Kim, Jae Hong Seo. Overexpression of angiotensin II type 1 receptor induces epithelial-mesenchymal transition and promotes tumorigenesis of human breast cancer cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1445. doi:10.1158/1538-7445.AM2015-1445
Polo-Like Kinase-1 (Plk-1) Inhibitor BI 2536 Induces Mitotic Arrest and Apoptosis in Vivo: First Demonstration of Target Inhibition in the Bone Marrow of AML Patients
Authors: Kang-Hun Lee, Richard F. Schlenk, Gesine Bug, Carsten Müller-Tidow, Ralph M. Waesch, David Nachbaur, Peter Valent, Gerd Munzert, Frank Fleischer, Hartmut Dohner, Pilar Garin-Chesa
Journal: Blood (2008)
Clinical, Radiographic, and Biomarker Characterization of Multiple Myeloma Patients with Bisphosphonate Associated Osteonecrosis of the Jaw.
Authors: Noopur Raje, Sook-Bin Woo, Karen Hande, Jeffrey T. Yap, Paul G. Richardson, Sonia Vallet, Nathaniel Treister, Teru Hideshima, Yu-Tzu Tai, Shweta Chhetri, Brendan Connell, Agnieszka Szot-Barnes, Mei Tian, Robert L. Schlossman, Edie Weeler, Nikhil C. Munshi, Annick D. Van Den Abbeele, Kenneth C. Anderson
Journal: Blood (2006)
Serum Concentration of L-Kynurenine Can Determine Clinical Outcome of Patients with Diffuse Large B-Cell Lymphoma Treated with R-CHOP
Authors: Soranobu Ninomiya, Hisashi Tsurumi, Takeshi Hara, Naoe Goto, Takeshi Yoshikawa, Junichi Kitagawa, Nobuhiro Kanemura, Senji Kasahara, Tsuyoshi Takami, Hisataka Moriwaki
Journal: Blood (2008)
Tacrolimus, Mini-Methotrexate and Mycophenolate Mofetil Is Safe and Effective as Acute Gvhd Prophylaxis for Non-Myeloablative Unrelated Donor Allogeneic Stem Cell Transplantation.
Authors: Sanghee Hong, Thomas Martin, Lloyd E. Damon, Lawrence Kaplan, Willis H. Navarro, Charles Linker
Journal: Blood (2009)
Multiple myeloma cells’ capacity to decompose H2O2 determines lenalidomide sensitivity
Authors: Sinto Sebastian, Yuan X. Zhu, Esteban Braggio, Chang-Xin Shi, Sonali C. Panchabhai, Scott A. Van Wier, Greg J. Ahmann, Marta Chesi, P. Leif Bergsagel, A. Keith Stewart, Rafael Fonseca
Journal: Blood (2016)
Predictors of mortality in chronic pulmonary aspergillosis
Authors: David Lowes, Khaled Al-Shair, Pippa J. Newton, Julie Morris, Chris Harris, Riina Rautemaa-Richardson, David W. Denning
Journal: European Respiratory Journal (2016)

Chronic pulmonary aspergillosis (CPA) is a chronic progressive infection that destroys lung tissue in non-immunocompromised patients. Contemporary series suggest 50-85% 5-year mortality, with few prognostic factors identified.A cohort of 387 CPA patients referred to the UK's National Aspergillosis Centre from 1992 to June 2012 was studied until June 2015. The impact of objective and subjective variables including age, sex, previous pulmonary conditions, dyspnoea score, quality of life, serum albumin and C-reactive protein and radiological appearances were assessed using Kaplan-Meier curves, log rank tests and Cox proportional hazards modelling. In samples of patients, retrospective review of time from likely onset of CPA to referral and cause of death were also investigated.Survival was 86%, 62% and 47% at 1, 5 and 10 years, respectively. Increased mortality was associated with nontuberculous mycobacterial infection (hazard ratio 2.07, 95% CI 1.22-3.52; p<0.001) and chronic obstructive pulmonary disease (1.57, 1.05-2.36; p=0.029) as well as higher age (1.053, 1.03-1.07 per year; p<0.001), lower albumin (0.92, 0.87-0.96 per g·L-1), lower activity (1.021, 1.01-1.03 per point increase in St George's Respiratory Questionnaire activity domain; p<0.001) and having one, and especially, bilateral aspergillomas (p<0.001).Several factors impact on mortality of CPA, and can be evaluated as tools to assess CPA prognosis.
Ongoing Management of Patients With Supraventricular Tachycardia
Authors: Sana M. Al-Khatib, Richard L. Page
Journal: JAMA Cardiology (2016)

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Abstract 19657: Histone Variant H2a.z And Cdk9 Differentially Regulate Transcriptional Rates During Cardiac Hypertrophy
Authors: Hyewon Shin, Zhi Yang, Danish Sayed, Minzhen He, Maha Abdellatif
Journal: Circulation (2015)

Genome-wide modifications in basic transcriptional activity underlie cardiac development and disease. We have previously reported that transcriptional regulation by RNA polymerase II (pol II) distinguishes different functional gene categories. In particular, transcription of constitutive, housekeeping, genes is regulated by a pause/release mechanism vs. de novo recruitment of pol II to cardiac-specific and inducible genes during cardiac hypertrophy in mice. Our objective is to identify the epigenetics and nuclear proteins that distinguish these transcriptional patterns. Using chromatin immunoprecipitation-deep sequencing (ChIP-Seq) we identified relatively high levels of H2A.z at the transcriptional start site of all housekeeping and inducible genes that exhibited only minimal or no changes in the heart before or after induction of pressure overload. In contrast, however, all cardiac-specific genes were consistently devoid of H2A.z. We also identified the specific interaction between H2A.z and acidic nuclear protein 32e (ANP32e), which inhibits the dephosphorylation and deactivation of cyclin-dependent kinase 9 (Cdk9) by protein phosphatase 2A (PP2A) and enhances its recruitment to chromatin. Accordingly, cardiac-specific and inducible genes diverge with regards to their regulation by Cdk9, where pressure overload induces a strict decrease vs. increase of Cdk9, respectively, at the promoter and gene body regions of these gene categories. Paradoxically, the reduction in Cdk9 in the former genes is accompanied by an increase in pol II levels, with a net result of little or no change in transcriptional rates. On the other hand, inducible genes are characterized by high levels of de novo recruitment of both pol II and Cdk9, with a sharp increase in transcriptional rates, which was specifically and completely inhibited by knockdown of Cdk9, or its inhibitors 5, 6- dichloro-1-β-D-ribofuranosyl-1H-benzimidazole or inhibitor II. Thus, the differential recruitment of H2A.z and Cdk9 determines the elongational rate of pol II that discriminates between the transcriptional rates of pressure overload-induced v. constitutively-expressed cardiac-specific genes.
Prognostic Factors For Children With Acute Myeloid Leukemia Who Achieve Minimal Residual Disease-Negative Status After Induction Therapy
Authors: Seth E Karol, Elaine Coustan-Smith, Xueyuan Cao, Sheila A Shurtleff, Susana C Raimondi, John K Choi, Raul C Ribeiro, Gary V Dahl, W Paul Bowman, Jeffrey W Taub, Barbara Degar, Wing Leung, James R Downing, Ching-Hon Pui, Jeffrey E Rubnitz, Dario Campana, Hiroto Inaba
Journal: Blood (2013)
The property of ovarian cancer stem-like cells and the prospect for immunotherapy targeted cancer stem-like cells
Authors: Takafumi Kuroda, Yoshihiko Hirohashi, Toshihiko Torigoe, Tasuku Mariya, Takuya Asano, Yudai Tabuchi, Masahito Mizuuchi, Masahiro Iwasaki, Noriyuki Sato, Tsuyoshi Saito
Journal: Annals of Oncology (2015)