tbuckley/cabot-search huggingface dataset:
Selective Occlusion with Fibrin Glue under Fistuloscopy: Seven Cases of Postoperative Management for Intractable Complex Fistulas
Authors: T. Kurokawa, S. Okushiba, M. Kadoya, D. Miyamoto, Y. Kurashima, H. Kitagami, J. Ikeda, M. Sunaga, Y. Shinzato, T. Ozawa, S. Kondo, H. Katoh
Journal: Endoscopy (2002)

Fistula occlusion is not achieved in some fistulas with complex branches. To obtain early fistula closure in such cases, we insert a double-lumen catheter into each fistula branch, with the aid of a guide wire positioned using a small-caliber endoscope, and attempt selective infusion of fibrin glue.Following removal of foreign bodies and necrotic granulation, we applied the selective occlusion method under fistuloscopic control to seven intractable external fistulas with complex branches, in which fistula closure had not been obtained by a simple occlusion method (SOM). All the fistulas were complex with more than two branches.Fistula occlusion was obtained within 2 weeks in six of the seven patients, and there has been no sign of recurrence over a follow-up period of 4 - 59 months (average 29.8 months).Selective occlusion under fistuloscopy is highly effective for intractable external fistulas with complex branches.
SP0135 What is New in Psoriatic Arthritis
Authors: R. Lories
Journal: Annals of the Rheumatic Diseases (2015)

The psoriatic disease concept includes psoriasis (PsO) and psoriatic arthritis (PsA). PsO is a chronic relapsing inflammatory skin disease characterized by scaling lesions, typically localized on the extensor surfaces and the trunk. PsA is a chronic inflammatory skeletal disease associated with PsO. PsA has heterogeneous clinical manifestations with some forms clearly linked to the spondyloarthritis (SpA) concept. PsA is a common disease, but many aspects of this disorder remain enigmatic. Lingering questions focus on the precise relationship between manifestations of joint and skin disease and on molecular and cellular mechanisms of inflammation and immunity that lead to the cardinal symptoms. During the last year new insights have been developed to shed further light on some of the enigmatic aspects of the disease. In addition to biological therapies targeting tumor necrosis factor, new treatments are shown to be effective for skin or joint disease. These include strategies directed against interleukin-17 and interleukin-23 but also non-biologic targeted therapies such as apremilast. Long-term data provide further insights into the management of the disease. In this regard, increased evidence for the necessity of treating comorbidity strongly supports the concept of a holistic disease management. Progress in imaging illustrates some key anatomic and pathophysiological concepts that help understanding the development, progression and consequences of the disease. Finally basic and translational science approaches identified key cell types and cytokines involved in the disease and link out towards the microbiome. Large investments into genetics of psoriatic arthritis finally seem to pay off by identifying factors that are specifically linked to the joint disease. <h3>Disclosure of Interest</h3> R. Lories Grant/research support from: Abbvie, Boehringer Ingelheim, Celgene, Pfizer, Consultant for: Abbvie, Boehringer Ingelheim, Celgene, Janssen, MSD, Pfizer, UCB
Rabbit Heart Cell Culture, Strain RHF-1. I. Growth, Cytology, Histology, and Susceptibility to Some Inclusion-Inducing Viruses&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Newton Khoobyarian, Catherine Gardella Palmer
Journal: JNCI Journal of the National Cancer Institute (1961)

A strain of fibroblast-like cells, rabbit heart cell culture, strain RHF-1, derived from the heart tissue of a normal domestic rabbit, has been cultivated serially in vitro over a period of 2 years. Morphologically, this strain has maintained its characteristic fibroblast-like appearance throughout the period in vitro. Chromosomal observation at intervals during serial transfers has shown conformity of type of chromosomes with those of the domestic rabbit while some variation is evidenced in numbers of each type correspondent to the degree of ploidy of that cell. Evidence is also presented that herpes simplex, pseudorabies, and vaccinia viruses grow and induce specific lesions in the cell cultures of strain RHF-1.
Phylogenetic and epidemiological analysis of measles outbreaks in Denmark, 2013 to 2014
Authors: Lasse Dam Rasmussen, Jannik Fonager, Lisbet Krause Knudsen, Peter Henrik Senten Andersen, Jesper Rønn, Mille Weismann Poulsen, Kristina Træholt Franck, Thea Kølsen Fischer
Journal: Eurosurveillance (2015)

Despite the introduction of safe, effective vaccines decades ago and joint global public health efforts to eliminate measles, this vaccine-preventable disease continues to pose threats to children’s health worldwide. During 2013 and 2014, measles virus was introduced into Denmark through several independent importations. This resulted in a number of secondary cases (n = 7), with two clusters in 2013 and one in 2014. In total, there were 44 cases of measles. Most cases (n = 41) were laboratory confirmed by detection of measles virus genome by real-time reverse transcription (RT)-PCR and IgM antibodies. The viruses from confirmed cases were genotyped by sequencing. Only one genotype circulated each year, i.e. D8 and B3, respectively. Sequencing of measles virus from different clinical specimens from the same patients revealed that sequence variants of measles viruses might co-exist and co-transmit during an outbreak. The majority of the cases were unvaccinated (n = 27) or recipients of one dose of measles-mumps-rubella (MMR) vaccine (n = 7). In addition, two fully vaccinated adult cases were reported in 2014. We demonstrate the transmission of measles virus in a population in which the two-dose MMR vaccination coverage rate was 80% and how even vaccinated individuals may be at risk of contracting measles once transmission has been established.
A Phase III Randomized Trial Comparing the Efficacy and Safety of the 3-Monthly 10.8-mg Depot of Zoladex with the Monthly 3.6-mg Depot in Patients with Advanced Prostate Cancer
Authors: P. Fernandez del Moral, J. W. M. H. Plasman, J. W. Hoefakker, J.G. Idema, M. Sykes, G. A. Dijkman, F. M. J. Debruyne
Journal: European Urology (1994)
The psychiatric chief residency: a preliminary training experience in administrative process
Authors: J G Looney, S J Engleberg, R O Gode, D J Knesper
Journal: American Journal of Psychiatry (1975)

Drawing on their experience, the authors explore the opportunity for learning administrative process that is available to the psychiatric chief resident. They categorize six models of the psychiatric chief residency and document two of them, the ward chief and the interface chief, as providing particularly rich administrative experiences. Although the chief resident's administrative experience is only a preliminary one, it can be a first step in solidifying his identity as a clinician-executive.
Two Centuries of a Medical School
Authors: E. J. H.
Journal: Annals of Internal Medicine (1965)

Editorial1 May 1965Two Centuries of a Medical SchoolE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-5-1061 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe year 1765 was in a doldrums of medical progress. Auenbrugger had publishedInventum Novum ex Percussione Thoracis Humani. . . in 1761, and Heberden was to describe in 1768 the definitive features of angina pectoris. Not much later, Withering was to establish the use of digitalis. Typified chiefly by such particular advances in method, practice, and clinical description, the eighteenth century was hardly stirred by winds of concept like those that had blown through the seventeenth century and were to freshen thought again in the century ahead. Harvey and Malpighi had already set their foundations for modern medicine,... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1965Volume 62, Issue 5Page: 1061-1062KeywordsAngina ePublished: 1 December 2008 Issue Published: 1 May 1965 PDF downloadLoading ...
THU0517 Invasive Fungal Infections Survey in 852 Childhood-Onset Systemic Lupus Erythematosus: A Multicenter Cohort
Authors: M.F. Silva, M.P. Ferriani, M.T. Terreri, R.M. Pereira, C.S. Magalhães, E. Bonfa, L.M. Campos, E.M. Okuda, S. Appenzeller, V.P. Ferriani, C.M. Barbosa, V.C. Ramos, S. Lotufo, C.A. Silva
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The majority of infections in childhood-onset systemic lupus erythematosus (cSLE) patients are caused by virus and bacteria, and less frequently by opportunistic agents, such as fungi.<sup>1</sup> However, studies evaluating solely invasive fungal infections (IFI) in cSLE patients are restricted to case reports or case series<sup>1</sup> without any systematic evaluation of the possible associated risk factors and outcomes in pediatric lupus population. <h3>Objectives</h3> To study the prevalence, risk factors and mortality of IFI in cSLE patients. <h3>Methods</h3> A retrospective multicenter cohort study was performed in 852 cSLE patients from 10 Pediatric Rheumatology services of São Paulo state, Brazil. An investigator meeting was held and all participants received database training. IFI were diagnosed according to EORTC/MSG Consensus Group (proven, probable and possible).<sup>2</sup> Demographic data, clinical, laboratorial, SLEDAI-2K, SLICC/ACR-DI, treatment and outcome were also evaluated. <h3>Results</h3> IFI were recorded in 33/852 (3.9%) cSLE patients. Proven IFI was evidenced in 22 cSLE patients, probable IFI in 5 and possible IFI in 6. The most frequent types of IFI were candidiasis (n=20) and aspergillosis (n=9). The median of disease duration was lower (1.0 vs. 4.7 years, p&lt;0.0001), with a higher current SLEDAI-2K [19.5 (0-44) vs. 2 (0-45), p&lt;0.0001] and current prednisone dose [50 (10-60) vs. 10 (2-90) mg/day, p&lt;0.0001] in patients with IFI compared to those without IFI. The frequency of death was higher in the former group (51% vs. 6%, p&lt;0.0001). Logistic regression analysis revealed that SLEDAI-2K (OR=1.108; 95%CI=1.057-1.163; p&lt;0.0001), current prednisone dose (OR=1.046; 95%CI=1.021-1.071; p&lt;0.0001) and disease duration (OR=0.984; 95%CI=0.969-0.998; p=0.030) were independent risk factors for IFI (R<sup>2</sup> Nagelkerke 0.425). <h3>Conclusions</h3> This was the first study that characterized IFI in a large cSLE population. We identified that disease activity and glucocorticoid use were the main risk factors for these life-threatening infections, mainly in early disease course and with a high rate of fatal outcome. <h3>References</h3> Silva MF, Ribeiro AS, Fiorot FJ, et al. Invasive aspergillosis: a severe infection in juvenile systemic lupus erythematosus patients. Lupus 2012;21:1011-6. De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008;46:1813-21. <h3>Disclosure of Interest</h3> None declared
Divorced fathers: predictors of continued paternal involvement
Authors: A V Tepp
Journal: American Journal of Psychiatry (1983)

The author investigated factors associated with continued involvement 3 years after divorce of fathers who did not have custody of their children. Feeling competent in the role of father, degree of involvement in child rearing 1 year after divorce, and the ease with which they were able to see their children were associated with fathers' greater participation 3 years after divorce. There was no relationship between how often a divorced father saw his children and how involved he felt in child rearing. All fathers were struggling with a sense of confusion and difficulty about their status as parents.
Effect of Medullectomy and Corticectomy on Renal Excretory Function in the Rat
Authors: H SOKABE, A GROLLMAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Inhibition of Estrogen-Induced Tissue Growth with Progesterone
Authors: Roy Hertz, C. D. Larsen, William Tullner
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Inhibition of Estrogen-Induced Tissue Growth with Progesterone Get access Roy Hertz, Roy Hertz National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar C. D. Larsen, C. D. Larsen National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar William Tullner William Tullner National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 3, December 1947, Pages 123–126, https://doi.org/10.1093/jnci/8.3.123 Published: 01 December 1947 Article history Received: 21 November 1947 Published: 01 December 1947
Phase I trial of oral CP-547,632 (VEGFR2) in combination with paclitaxel (P) and carboplatin (C) in advanced non-small cell lung cancer (NSCLC)
Authors: R. B. Cohen, G. Simon, C. J. Langer, J. R. Schol, J. McHale, P. Eisenberg, J. D. Hainsworth, K. F. Liau, D. Healey
Journal: Journal of Clinical Oncology (2004)

3014 Background: Overexpression of vascular endothelial growth factor (VEGF) portends a poor outcome in NSCLC. Tumor angiogenesis may be mediated by VEGF signaling through the VEGF receptor-2 (VEGFR-2). CP-547, 632 is a potent, selective inhibitor of VEGFR-2 tyrosine kinase activity. The addition of CP-547,632 to chemotherapy may enhance clinical benefit. Methods: This study examined the safety and PK of escalating oral QD doses of CP-547,632 given in combination with P(225mg/m2) and C( AUC = 6) administered in 21 day cycles to chemotherapy naïve patients with PS 0–1 stage IIIb or IV NSCLC with or without stable brain mets and PS 0–1. Anti-tumor activity was also assessed. Results: 29 patients received a median of 2+ cycles (range 1–13) of study therapy. In this setting, the maximum tolerable dose for CP-547,632 was 200 mg/d. Preliminary safety data reveal the most common treatment emergent adverse events to be diarrhea, fatigue, nausea, neuropathy, emesis, alopecia, dyspnea and arthralgia/myalgia. CP-547,632 has a half-life of approximately 32 hours and, at doses ≥ 150mg QD, achieves plasma concentrations within the range associated with anti-angiogenesis in preclinical models. In the 24 patients evaluable for response, a 20% objective response rate and a 33% progressive disease rate were observed. An additional 6 patients were enrolled to the expansion portion of the trial. In this group, confirmation of the safety of CP-547,632 at 200mg when given with P/C and assessment of any PK interaction of CP-547,632 with P/C are ongoing. Conclusions: 200mg, QD oral CP-547,632 can be safely combined with standard doses of P/C. This trial supports investigation in the Phase II setting. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pfizer, Inc. Pfizer Pfizer
Intraperitoneal adoptive immunotherapy for peritoneal cancer.
Authors: J S Berek
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.10.1610 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2213098 Intraperitoneal adoptive immunotherapy for peritoneal cancer. J S BerekxJ S BerekSearch for articles by this author Show More University of California, Los Angeles School of Medicine, Jonsson Comprehensive Cancer Center. https://doi.org/10.1200/JCO.1990.8.10.1610 First Page PDF © 1990 by American Society of Clinical Oncology
Laboratory Aids in Diagnosis of Cancer.
Authors: F D SPEER
Journal: Annals of Internal Medicine (1969)

The middle and latter thirds of the book comprise a detailed dictionary, occupying another 650 pages, of analytical data from Acepifylline to Yohimbine, with MP and Rf values, u-v maxima, i-v peaks and char- acteristic spectra, reagent data-and a very full bibliography.It is a remarkable book: a vade mecum every analytical chemist and toxicologist must have at his elbow.It is, indeed, the only really full and authoritative guide in this difficult field, of equal importance to both clinical and postmortem toxicologists.The price is immaterial.
Abstract 4760: Stromal contribution to the colorectal cancer transcriptome
Authors: Claudio Isella, Andrea Terrasi, Sara E. Bellomo, Consalvo Petti, Andrea Muratore, Alfredo Mellano, Mark De Ridder, Paola Cassoni, Guy Storme, Andrea Bertotti, Enzo Medico
Journal: Cancer Research (2015)

Abstract Recent studies have identified a stem/serrated/mesenchymal (SSM) molecular subtype of colorectal cancer (CRC) that is associated with poor prognosis. We noted that genes upregulated in this subtype are also prominently expressed by stromal cells. This led us to hypothesize that the SSM transcripts could derive from the tumor microenvironment, rather than being intrinsic to cancer cells. To test this hypothesis, we analyzed microarray and RNAseq expression data from patient-derived xenografts (PDXs) of CRC, where human cancer cells are supported by murine stroma. Species-specific expression analysis revealed that mRNA levels of SSM genes are mostly due to stromal expression. Considering only genes exclusively expressed by stromal cells in PDXs, We then built three expression signatures specifically reporting the abundance of cancer-associated fibroblasts (CAFs), leucocytes or endothelial cells. In human CRC samples, all stromal signatures were strongly associated with the SSM subtype. A high CAF signature was associated with poor prognosis in untreated CRC patients, while in rectal cancer high stromal signatures jointly predicted radioresistance. These data show that the distinctive transcriptional and clinical features of the SSM subtype can be ascribed to its particularly abundant stroma. Citation Format: Claudio Isella, Andrea Terrasi, Sara E. Bellomo, Consalvo Petti, Andrea Muratore, Alfredo Mellano, Mark De Ridder, Paola Cassoni, Guy Storme, Andrea Bertotti, Enzo Medico. Stromal contribution to the colorectal cancer transcriptome. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4760. doi:10.1158/1538-7445.AM2015-4760
PTU-293 Hes data for ulcerative colitis demonstrates the critical role of the ibd nurse specialist in preventing a&amp;e attendance
Authors: B Hayee, P Dubois, A Walters, T Bedwell, J Tumova, J Duncan, H Curtis, P Irving, I Forgacs
Journal: Gut (2015)

<h3>Introduction</h3> A key role for an Inflammatory Disease Nurse (IBD) nurse specialist is to act as a first point of contact with secondary care, and as an alternative to the Emergency Department (ED), for a patient with IBD who thinks they may be experiencing a relapse. This opportunistic and observational study allowed the potentially crucial importance of this component of the IBD nurse specialist role to be evaluated. <h3>Method</h3> Using hospital episode statistic (HES) data for 2013 (source and acknowledgement….) we analysed the month-by-month variation in ED visits for UC across three NHS Trusts in our region. At Trust 1, a single-handed IBD nurse has been in post since 2002, with a temporary loss of service experienced in April–May 2013, then a planned evaluation of a nurse-led telephone helpline May–Nov 2013 only. At Trust 2, a single-handed IBD nurse was appointed in January 2013 while Trust 3 maintained a stable, hierarchical service with a lead nurse and two junior team members. Comparison of non-linear (cubic) regression curves was with the extra sum of squares F test (GraphPad Prism v4.0). <h3>Results</h3> In 2013, there were 144 episodes recorded at Trust 1, 129 at Trust 2 and 90 at Trust 3. The Figure 1below shows the pattern of ED attendances over the year. Trust 1 recorded zero admissions in Jan-Mar, with a dramatic peak in April coinciding with the loss of service, then settling with the provision of the telephone helpline and rising again with the planned withdrawal of this service (periods shown by shaded bar at top of graph). Trust 2 experienced a gradual decline in attendances (IBD nurse post start denoted by vertical arrow). Trust 3 experienced a stable rate of attendances. A statistically significant difference was observed, and analysing data as a proportion of OP activity or number of medical beds did not affect this analysis. <h3>Conclusion</h3> The loss of an IBD nurse specialist is associated with a dramatic rise in ED attendance, while new provision appears to reduce this KPI. Data were not available for 2012, but will be forthcoming for 2014 to determine the durability and magnitude of the trends observed in this study. <h3>Disclosure of interest</h3> None Declared.
Arterial Puncture
Authors: Russell L. Malcolm
Journal: JAMA (1974)

<h3>To the Editor.—</h3> Pathologists know better about arterial puncture than clinicians, and what personnel should obtain the samples (228:763, 1974). We started doing arterial punctures in the usual manner. A pathologist or attending physician drew the specimen during daylight hours, and an appropriate physician drew it at other times. Then we taught the technique to ASCP medical technologists. We have now gone the whole distance, and all our medical technologists, medical technicians, and certified laboratory assistants (CLAs) do arterial punctures. We don't teach the technique to CLA students, but do teach those CLAs we employ after graduation who work in the chemistry area. This has been in effect for a year now, with no problems. In fact, from the beginning, some physicians had not done arterial punctures, were not about to start, and were delighted that the technicians became proficient.