tbuckley/cabot-search huggingface dataset:
Tumor Environment Contributes to Brain Tumor Resistance
Authors: Tracy Hampton
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stent Retrievers for Treating Anterior Circulation Acute Ischemic Stroke
Authors: Marino Muxfeldt Bianchin, Rosane Brondani, Andrea Garcia de Almeida
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Integration of antimicrobial peptides with gold nanoparticles as unique non-viral vectors for gene delivery to mesenchymal stem cells with antibacterial activity
Authors: Li-Hua Peng, Yan-Fen Huang, Chen-Zhen Zhang, Jie Niu, Ying Chen, Yang Chu, Zhi-Hong Jiang, Jian-Qing Gao, Zheng-Wei Mao
Journal: Biomaterials (2016)
SURGICAL MANAGEMENT OF ULCERATIVE COLITIS IN CHILDREN
Authors: E W Fonkalsrud, P Levin, W F Barker
Journal: JAMA (1968)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Summary of Notifiable Noninfectious Conditions and Disease Outbreaks: Surveillance for Silicosis — Michigan and New Jersey, 2003–2010
Authors: Margaret S. Filios, Jacek M. Mazurek, Patricia L. Schleiff, Mary Jo Reilly, Kenneth D. Rosenman, Margaret E. Lumia, Karen Worthington
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

S ilicosis is the disease most associated with crystalline silica exposure; it is incurable but preventable.This debilitating and often fatal lung disease persists worldwide despite long-standing knowledge of its cause and methods for controlling it.This Hazard Review, Health Effects of Occupational Exposure to Respirable Crystalline Silica, describes published studies and literature on the health effects of occupational exposure to respirable crystalline silica among workers in the United States and many other countries.The review indicates a significant risk of chronic silicosis for workers exposed to respirable crystalline silica over a working lifetime at the current Occupational Safety and Health Administration (OSHA) permissible exposure limit (PEL), the Mine Safety and Health Administration (MSHA) PEL, or the National Institute for Occupational Safety and Health (NIOSH) recommended exposure limit (REL).In addition to the risk of silicosis, epidemiologic studies indicate that workers exposed to respirable crystalline silica have an increased risk of developing lung cancer, pulmonary tuberculosis, and airways diseases.The latest scientific information also indicates possible associations of occupational exposure to silica dust with various other adverse health effects.Until improved sampling and analytical methods are developed for respirable crystalline silica, NIOSH will continue to recommend an exposure limit of 0.05 mg/m 3 as a time-weighted average (TWA) for up to a 10-hr workday during a 40-hr workweek.NIOSH also recommends substituting less hazardous materials for crystalline silica when feasible, using appropriate respiratory protection when source controls cannot keep exposures below the REL, and making medical examinations available to exposed workers.
An international, population-level initiative to promote healthy lifestyle practices among prostate cancer survivors.
Authors: June M. Chan, Robert Usher Newton, S. Nicole Culos-Reed, Sarah Faithfull, Sylvie Lambert, Stacey A. Kenfield, Erin Van Blarigan, Karen S Lyons, Justin Ramsdill, Ashley Zahavich, Lindsay Duncan, Nicolas Hart, Mike Dew, Esther L Moe, Cyril Dixon, Kerri M Winters-Stone
Journal: Journal of Clinical Oncology (2016)

e287 Background: Growing evidence suggests that specific lifestyle practices (e.g., diet and exercise) may delay cancer progression among prostate cancer survivors (PCS) and restore post-treatment quality of life. However, there are limited efforts to translate this knowledge to sustainable behavior change among PCS at a population level. Methods: TrueNTH is an international partnership to develop innovative evidence-based interventions and care models to improve the physical and mental wellbeing of PCS. Within TrueNTH, four countries (U.S.A., Australia, Canada, U.K.) are developing solutions to improve lifestyle practices among PCS. Australia is implementing face-to-face and telehealth delivery of exercise and dietary programs facilitated by a web-based portal. Canada is implementing group-based exercise and yoga programs combined with a web-based portal to deliver exercise, nutrition and stress-reduction resources for PCS and caregivers. The U.K. is implementing a healthy living pharmacy approach to deliver tailored diet and exercise advice and support to men. The U.S. will implement a scalable web-based portal that reaches PCS, providers and partners and provides personalized exercise prescriptions and dietary advice, interactive guidance, and behavioral support via social media, tele-exercise, and face-to-face communities. Results: TrueNTH initiatives are in various phases of a three-year project. Australia has enrolled 30 of 80 men across 2 sites and via telehealth, and demonstrated acceptance of the portal. Canada has enrolled 30+ men in exercise programs and will soon add 4 sites and launch their portal. The UK has evaluated assessment protocols in 2 sites and will soon add a 3 rd site and implement the pharmacy-based program. The U.S. is building the portal and supportive tools and will begin a trial in Fall 2016. Conclusions: Each TrueNTH program shares common goals to improve lifestyle practices among PCS. Common metrics across initiatives will allow for a global comparison of implementation approaches and assessment of impact at a population level. TrueNTH will utilize this initiative to create a lifestyle survivorship program that improves the lives of PCS worldwide.
A prospective cohort study of 7031 distance runners shows that 1 in 13 report systemic symptoms of an acute illness in the 8–12 day period before a race, increasing their risk of not finishing the race 1.9 times for those runners who started the race: SAFER study IV
Authors: Anri Van Tonder, Martin Schwellnus, Sonja Swanevelder, Esme Jordaan, Wayne Derman, Dina C Janse van Rensburg
Journal: British Journal of Sports Medicine (2016)

Data on the prevalence of acute illness in the period prior to a distance running race are limited. Currently, the presence of systemic symptoms (failed 'neck check') is used to advise athletes on participation.To determine (1) the period prevalence of pre-race acute illness symptoms before a distance running event, (2) if symptomatic runners receiving educational material on acute illness did not start (DNS) the race and (3) if symptomatic runners who chose to start the race, did not finish (DNF) the race.7031 runners completed an online pre-race acute illness questionnaire in the 3-5 day period prior to a race. Symptomatic runners received educational information on exercise and acute illness. Runners were followed prospectively to determine DNS and DNF risk.1338 runners (19.0%) reporting symptoms (7.5% reporting systemic symptoms-failed 'neck check') and receiving educational information had a higher DNS frequency (11.0%) compared to controls (6.6%)(p=0.0002). Symptomatic runners who started the race had a higher DNF frequency (2.1%) compared to controls (1.3%) (p=0.0346), particularly runners with systemic symptoms (2.4%; RR=1.90).In summary, 19% (1 in 5) runners reported pre-race acute illness symptoms, with 7.5% (1 in 13) reporting systemic symptoms. Although runner education reduced the percentage symptomatic race starters, the majority of them still chose to race, resulting in a two times higher risk of not finishing in those with systemic symptoms. Pre-race acute illness symptoms are common; an educational intervention affects an athlete's decision to compete yet most symptomatic runners still competed, and systemic symptoms negatively affect performance, with possible health implications.
Circulating tumor DNA analysis detects minimal residual disease and predicts recurrence in patients with stage II colon cancer
Authors: Jeanne Tie, Yuxuan Wang, Cristian Tomasetti, Lu Li, Simeon Springer, Isaac Kinde, Natalie Silliman, Mark Tacey, Hui-Li Wong, Michael Christie, Suzanne Kosmider, Iain Skinner, Rachel Wong, Malcolm Steel, Ben Tran, Jayesh Desai, Ian Jones, Andrew Haydon, Theresa Hayes, Tim J. Price, Robert L. Strausberg, Luis A. Diaz, Nickolas Papadopoulos, Kenneth W. Kinzler, Bert Vogelstein, Peter Gibbs
Journal: Science Translational Medicine (2016)

Detection of circulating tumor DNA in patients with resected stage II colon cancer provides evidence of residual disease.
Phase II Study of Hemithoracic Intensity-Modulated Pleural Radiation Therapy (IMPRINT) As Part of Lung-Sparing Multimodality Therapy in Patients With Malignant Pleural Mesothelioma
Authors: Andreas Rimner, Marjorie G. Zauderer, Daniel R. Gomez, Prasad S. Adusumilli, Preeti K. Parhar, Abraham J. Wu, Kaitlin M. Woo, Ronglai Shen, Michelle S. Ginsberg, Ellen D. Yorke, David C. Rice, Anne S. Tsao, Kenneth E. Rosenzweig, Valerie W. Rusch, Lee M. Krug
Journal: Journal of Clinical Oncology (2016)

We conducted a two-center phase II study to determine the safety of hemithoracic intensity-modulated pleural radiation therapy (IMPRINT) after chemotherapy and pleurectomy-decortication (P/D) as part of a multimodality lung-sparing treatment.Patients received up to four cycles of pemetrexed plus platinum. If feasible, P/D was performed. Hemithoracic IMPRINT was administered to a planned dose of 50.4 Gy in 28 fractions. The primary end point was the incidence of grade 3 or greater radiation pneumonitis (RP).A total of 45 patients were enrolled; 18 were not evaluable (because of disease progression before radiation therapy [RT], n = 9; refusal of surgery or RT, n = 5; extrapleural pneumonectomy at time of surgery, n = 2; or chemotherapy complications, n = 2). A total of 26 patients received pemetrexed plus cisplatin, 18 received pemetrexed plus carboplatin, and four received a combination. Thirteen patients (28.9%) had a partial response, 15 patients (33.3%) experienced disease progression, one patient died during chemotherapy, and all others had stable disease. Eight patients underwent P/D or an extended P/D, and 13 underwent a partial P/D. A total of 27 patients started IMPRINT (median dose, 46.8 Gy; range, 28.8 to 50.4 Gy) and were evaluable for the primary end point (median follow-up, 21.6 months). Six patients experienced grade 2 RP, and two patients experienced grade 3 RP; all recovered after corticosteroid initiation. No grade 4 or 5 radiation-related toxicities were observed. The median progression-free survival and overall survival (OS) were 12.4 and 23.7 months, respectively; the 2-year OS was 59% in patients with resectable tumors and was 25% in patients with unresectable tumors.Hemithoracic IMPRINT for malignant pleural mesothelioma (MPM) is safe and has an acceptable rate of RP. Its incorporation with chemotherapy and P/D forms a new lung-sparing treatment paradigm for patients with locally advanced MPM.
Cross‐reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay
Authors: J.F. Schwensen, C. Menné Bonefeld, C. Zachariae, C. Agerbeck, T.H. Petersen, C. Geisler, U.E. Bollmann, K. Bester, J.D. Johansen
Journal: British Journal of Dermatology (2016)

BackgroundIn the light of the exceptionally high rates of contact allergy to the preservative methylisothiazolinone (MI), information about cross‐reactivity between MI, octylisothiazolinone (OIT) and benzisothiazolinone (BIT) is needed.
Staff shortages are impeding efforts to improve cancer outcomes in England
Authors: Matthew Limb
Journal: BMJ (2016)

Cancer specialists have called for action to tackle the staff shortages that threaten plans to improve care and outcomes for people with cancer.

In July 2015 the Independent Cancer Taskforce published a five year strategy for achieving world class outcomes in England by 2020.1 Sarah Woolnough, a taskforce member and Cancer Research UK’s head of policy, spoke about the progress that had been made during the last year at a cancer care seminar in London on 11 July. …
Personal views: : Doctors and patients dance together
Authors: Arthur Smith
Journal: BMJ (2002)

Doctor and patient sway together in an eternal dance. They need each other, and you cannot describe one without reference to the other. I never had much need for doctors until I was 47, at which point I seemed to have the need for lots of them. Lying in bed in hospital all day I was able to observe them in their natural habitat. I learnt not to worry about staring because doctors do not see you except when it's your turn.
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Authors: Kelly K. Ferguson, Yin-Hsiu Chen, Tyler J. VanderWeele, Thomas F. McElrath, John D. Meeker, Bhramar Mukherjee
Journal: Environmental Health Perspectives (2016)

Mediation analysis is useful for understanding mechanisms and has been used minimally in the study of the environment and disease.We examined mediation of the association between phthalate exposure during pregnancy and preterm birth by oxidative stress.This nested case-control study of preterm birth (n = 130 cases, 352 controls) included women who delivered in Boston, Massachusestts, from 2006 through 2008. Phthalate metabolites and 8-isoprostane, an oxidative stress biomarker, were measured in urine from three visits in pregnancy. We applied four counterfactual mediation methods: method 1, utilizing exposure and mediator averages; method 2, using averages but allowing for an exposure-mediator interaction; method 3, incorporating longitudinal measurements of the exposure and mediator; and method 4, using longitudinal measurements and allowing for an exposure-mediator interaction.We observed mediation of the associations between phthalate metabolites and all preterm birth by 8-isoprostane, with the greatest estimated proportion mediated observed for spontaneous preterm births specifically. Fully utilizing repeated measures of the exposure and mediator improved precision of indirect (i.e., mediated) effect estimates, and including an exposure-mediator interaction increased the estimated proportion mediated. For example, for mono(2-ethyl-carboxy-propyl) phthalate (MECPP), a metabolite of di(2-ethylhexyl) phthalate (DEHP), the percent of the total effect mediated by 8-isoprostane increased from 47% to 60% with inclusion of an exposure-mediator interaction term, in reference to a total adjusted odds ratio of 1.67 or 1.48, respectively.This demonstrates mediation of the phthalate-preterm birth relationship by oxidative stress, and the utility of complex regression models in capturing mediated associations when repeated measures of exposure and mediator are available and an exposure-mediator interaction may exist. Citation: Ferguson KK, Chen YH, VanderWeele TJ, McElrath TF, Meeker JD, Mukherjee B. 2017. Mediation of the relationship between maternal phthalate exposure and preterm birth by oxidative stress with repeated measurements across pregnancy. Environ Health Perspect 125:488-494; http://dx.doi.org/10.1289/EHP282.
Endoscope reprocessing – painted into a corner?
Authors: Lars Aabakken
Journal: Endoscopy (2016)

The inherent issue of reusable complex instruments – such as flexible endoscopes – being incompatible with heat-based sterilization has been recognized for decades, prompting ever-developing guidelines for optimal reprocessing [1] [2]. High level disinfection (HLD) is an integral part of quality endoscopy, which combined with appropriate manual cleaning and drying/storage has been thought to offer a satisfactory safeguard against retained contamination and potential microbial transmission between patients. Indeed, most reported endoscope-transmitted infections used to be linked to technical failures or lack of adherence to reprocessing standards.
Sick Populations and Sick Subpopulations
Authors: Yuan Lu, Majid Ezzati, Eric B. Rimm, Kaveh Hajifathalian, Peter Ueda, Goodarz Danaei
Journal: Circulation (2016)

Cardiovascular disease (CVD) death rates are much higher in blacks than whites in the United States. It is unclear how CVD risk and events are distributed among blacks versus whites and how interventions reduce racial disparities.
High Frequency of Dysphoric Reactions to Tetrahydrocannabinol Among Depressed Patients
Authors: Steven L. Ablon, Frederick K. Goodwin
Journal: American Journal of Psychiatry (1974)

This study reports a high incidence of dysphoric reactions to Δ9-tetrahydrocannabinol (THC) administered under double-blind conditions to a well-defined homogeneous population of hospitalized patients with unipolar depressive illness. Personality characteristics that might predispose patients to dysphoric reactions are examined and the implications of the effect of THC on the mood of depressed patients are discussed.
p53 interacts with the spliceosomal protein SAP145 and affects pre-mRNA processing
Authors: Lan N. Truong, Klemens J. Hertel, Rainer K. Brachmann
Journal: Cancer Research (2005)

4599   The tumor suppressor protein p53 functions to maintain cellular homeostasis and to prevent tumorigenesis by mediating cell cycle arrest and/or apoptosis in response to cellular stress and DNA damage. p53 primarily acts as a transcription factor, but it has become clear that p53 uses additional mechanisms of action to affect cellular processes. Through a p53 dissociator screen in yeast, we uncovered a set of new p53-interacting proteins, including the spliceosome associated protein 145kDa (SAP145). SAP145 is a core component of the U2 small nuclear ribonucleoprotein subunit of the spliceosome complex. The discovery of a splicing protein from the screen is interesting because it suggests a novel role for p53 in splicing which could have direct implications for p53’s functions in cancer biology. We have established that p53 interacts with SAP145 by coimmunoprecipitation of over-expressed p53 and FLAG-tagged SAP145. We have also determined that the N-terminus of p53 and the N-terminus of SAP145 are important for their physical interaction. Furthermore, activated p53 can affect the stability of SAP145 by decreasing protein levels of both full-length SAP145 and the N-terminus of SAP145, as shown by Western Blotting. However, p53 does not decrease protein levels of the C-terminus of SAP145. These results indicate that the interaction between p53 and SAP145, in particular the N-terminus of SAP145, affects SAP145 protein stability and may consequently affect pre-mRNA processing. To study the functional roles of p53 in pre-mRNA splicing, we performed RT-PCR analysis to examine the alternative splicing patterns of two different minigenes: survival motor neuron 2 (SMN2) and alpha-globin fibronectin (alpha-glob FN). p53 was shown to affect the alternative splicing pattern of exon 7 of SMN2 and the EDI exon of alpha-glob FN transcripts. Activated p53 also affects alternative splicing of endogenous p53-inducible gene 3 (PIG3) transcripts. We are currently examining p53’s effects on splicing of other endogenous p53 target genes involved in cell cycle arrest and apoptosis. Continued RT-PCR analyses will focus on how the interaction of p53 and SAP145 (and its consequences on SAP145 stability) affect p53-mediated alternative splicing of these gene products. The connection of the splicing factor SAP145 to p53 biology is intriguing in that it implicates a novel role for p53 in pre-mRNA splicing which may be linked to p53-mediated cellular outcomes of cell cycle arrest and apoptosis. Our data demonstrate not only a physical interaction between p53 and SAP145 but also show that p53 can affect SAP145 protein stability. We propose that p53 interacts with SAP145 to affect pre-mRNA splicing. By studying this interaction and its functional consequences, we will better understand how the tumor suppressor protein p53 regulates gene expression at the post-transcriptional level.
Primary Cultivation and Continuous Propagation &lt;italic&gt;In Vitro&lt;/italic&gt; of Tissues From Small Biopsy Specimens&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: T. C. Hsu, Douglas S. Kellogg, Jr.
Journal: JNCI Journal of the National Cancer Institute (1960)

A method is described for cultivation of small biopsy specimens in vitro with high frequency of success. A relatively safe method for transferring and propagating cells is also described. These procedures enable investigators to establish cell lines from limited quantities of initial material. In securing cellular material from human hereditary diseases for cytological and/or biochemical investigations, these techniques may be helpful.