tbuckley/cabot-search huggingface dataset:
SAT0290 Prospective Observational Study of 5-Year Follow-Up of Distal Radius Fractures in a Trauma Center
Authors: M. Lisbona, C. Aguilera, P. Leon, M. Anaya, E. Rubio, J. Povedano, M. Muñoz
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Distal radius fracture is considered the first fragility fracture. A linear increase of these fractures in women over age 55 is observed. <h3>Objectives</h3> To describe the baseline characteristics of patients over 55 years with a diagnosis of Distal radius fracture initially treated in the Emergency area and required hospitalization in 2009 in the Traumatology and Rehabilitation Hospital Virgen del Rocío de Sevilla and monitoring after over 5 years. <h3>Methods</h3> Prospective observational study of 5-year follow-up of a cohort of patients, women older than 55 years who required surgery in 2009 of Distal radius fracture occurred by accidental fall, excluding traffic accidents and precipitation and if the risk of osteoporosis was evaluated during follow-up over the next 5 years. Baseline characteristics were studied: age, smoking, taking steroids, personal history of Rheumatoid Arthritis, if they had previous bone densitometry and the presence of previous fragility fractures. During follow assessed whether patients were referred to Rheumatology to assess risk of Osteoporosis, if bone densitometry later, if presented after osteoporotic fractures (vertebral, non hip peripheral fractures and hip fractures) and if received specific treatment for the Osteoporosis <h3>Results</h3> 52 women were included in the study with a mean age of 69.69±8.748 years. 55-88 years range. Between baseline characteristics studied were found 5.8% (3 patients.) Were smokers, 13.2% (7 patients.) Were steroid takers regularly, 3.8% (2 patients.) With Rheumatoid Arthritis, 9.6% (5 patients.) had a history of previous fragility fractures. During the follow up period of 5 years 14 patients (26.9%) had osteoporotic fractures, including vertebral fractures 6 patients found. (11.5%), peripheral non hip fractures 5 patients. (9.6%) and hip fractures 4 patients. (7.7%). 12 patients were derived. (23.1%) a Rheumatology specialist for risk assessment of Osteoporosis, 9 patients. (17.3%) underwent bone densitometry and 10 patients (19.2%) received specific treatment for Osteoporosis. <h3>Conclusions</h3> Distal radius fracture is the result of a fall on an outstretched arm. It is considered the first fragility fracture. Presents an increased incidence after 55 years. In our study, it is noteworthy that 26.9% of patients who suffered a Distal radius fractured submitted an osteoporotic fracture during the follow up period of 5 years, including 7.7% were hip fractures in consequent increase in morbidity and mortality. However, only 23% of patients were referred to Rheumatology for risk assessment of Osteoporosis. Therefore, we must continue to emphasize proper evaluation of Osteoporosis risk of these fractures in the Emergency area. <h3>Disclosure of Interest</h3> None declared
Follow-up study of control subjects with lactate- and isoproterenol- induced panic attacks
Authors: R Balon, R Pohl, V K Yeragani, J M Rainey, R Berchou
Journal: American Journal of Psychiatry (1988)

Eleven of 45 normal control subjects experienced panic attacks during lactate and/or isoproterenol infusions. Ten of the 11 subjects were followed up for a mean period of 32.5 months. Two subjects reported the development of spontaneous panic attacks during the follow-up period; one related the development of these attacks to the infusion experience. Neither subject met DSM-III criteria for panic disorder either before or after the infusions. Twenty-six healthy control subjects who did not experience panic attacks during the infusion experience did not report any attacks during a follow-up period of 31.1 months.
AB0118 Pro-Resolving Mediators Issued from Apoptotic Cell Efferocytosis (Supermapo) Modulate APC Properties Toward a Tolerogenic Profile: Efficacy in the Treatment of Collagen-Induced Arthritis
Authors: F. Bonnefoy, R. Vallion, M. Couturier, A. Daoui, E. Toussirot, S. Perruche
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Pro-resolving mediators produced by macrophages eliminating apoptotic effector cells during the resolution of inflammation have been shown to stop inflammation, favor tissue repair and return to homeostasis. In immune-mediated inflammatory diseases such as rheumatoid arthritis (RA), one may believe that reintroducing pro-resolving mediators would allow the control of the disease. We have developed a cell culture system of macrophages and apoptotic cells that mimics this phase of resolution. The supernatant of this cell culture system called SuperMApo (<i>SUPERnatant issued from Macrophage APOptotic cell culture</i>) is enriched in pro-resolving factors including anti-inflammatory cytokines like TGF-b. <h3>Objectives</h3> To evaluate the effects of SuperMApo in the treatment of collagen-induced arthritis (CIA). <h3>Methods</h3> SuperMApo is obtained after 48h of culturing macrophages from peritoneal cavity with apoptotic cells obtained from thymus after X-ray irradiation. CIA was used as a model of RA. SuperMApo (200 μL of 5x concentrated SuperMApo, IV, for 2 days) was injected in score 8 CIA mice. The effect of SuperMApo was first evaluated on APC and T cells from naïve mice in terms of phenotype, profile and properties such as maturation of APC before or after TLR-ligand stimulation and T cell polarization assays. Then, SuperMApo was evaluated <i>in vivo</i> in CIA mice. <h3>Results</h3> Macrophages, cDC and pDC submitted to SuperMApo demonstrated robust insensitivity to TLR ligand-induced activation, particularly in terms of co-stimulatory molecules expression. Spleen cells cultured with SuperMApo demonstrated a strong Treg increase. This was confirmed using naïve CD4<sup>+</sup>CD25<sup>-</sup> T cells cultured in the presence of SuperMApo showing Foxp3 expression. CIA mice received 2 injections of SuperMApo (over 48h) and demonstrated a significant long term decrease of CIA (joint score before and after SuperMApo: 8-10 and 1-4, respectively; sustained response to 60 days). This clinical improvement was associated with a higher suppressive function of Treg. Treg transfer from mice treated by SuperMApo to arthritic mice induced joint improvement. Finally, we tested SuperMApo effect on PBMC issued from 4 patients with RA, with and without TLR ligand activation. Our results were that monocytes from 3 patients showed a decreased inflammatory phenotype after overnight exposure to SuperMApo (CD80, CD86, CD40 and HLA-DR expression). <h3>Conclusions</h3> These data demonstrated that macrophages eliminating apoptotic cells produced pro-resolving mediators affecting APC properties therefore allowing the control of arthritis in the CIA model. <h3>Disclosure of Interest</h3> None declared
New targeted therapies for non-small-cell lung cancer: a focus on the epidermal growth factor receptor.
Authors: Jeffrey Crawford
Journal: Journal of the National Comprehensive Cancer Network (2003)

Advances in chemotherapy and multimodality treatments of patients with non-small-cell lung cancer (NSCLC) have improved outcomes for these patients over the past decade. Unfortunately, gains have been modest, and new therapeutic strategies are eagerly awaited. Therapies that target receptors vital to the proliferation and survival of cancer cells are particularly attractive areas of research. The epidermal growth factor receptor (EGFR) is widely expressed in NSCLC. Preclinical studies demonstrate that inhibition of EGFR using antibodies or tyrosine kinase inhibitors has led to growth inhibition and tumor regression in a variety of models. A number of agents are currently in clinical trials; the most information in NSCLC is currently available on the tyrosine kinase inhibitors. Phase II trials involving patients with advanced NSCLC and whose disease is progressive after chemotherapy have demonstrated clear clinical benefit. Studies are ongoing, integrating EGFR-targeted therapy with chemotherapy and radiation in patients with earlier stage NSCLC, as well as in chemoprevention. In all of these settings, a further understanding of the biology of EGFR in relationship to other cellular events will be critical in optimizing therapeutic approaches with these novel agents.
PWE-366 The bowel cancer screening programme (bcsp) pathology expert board: five years’ experience of an extraordinary pathological diagnostic conundrum
Authors: R Griggs, S Noormohamed, J Vella, C Foy, S Sanders, MR Novelli, NA Shepherd
Journal: Gut (2015)

<h3>Introduction</h3> Adenomatous polyps of the colon, especially of the sigmoid colon, can show epithelial misplacement into the submucosa.<sup>1 </sup>Also termed pseudo-invasion, this feature can strongly mimic invasive adenocarcinoma. Recently described as the “diagnostic conundrum of the century”,<sup>2 </sup>it is recognised that the differential diagnosis of polyp cancer versus epithelial misplacement poses particular difficulty for pathologists.<sup>3 </sup>A national Expert Board (EB) was established in 2009 to provide a consensus histopathological diagnosis for challenging cases. The aim of this study was to review the first five years of the BCSP EB and to assess its effectiveness in a very difficult diagnostic area. <h3>Method</h3> A retrospective review was performed of all cases referred to the Expert Board in a five year period from its inception, in 2009, to 2013. Records were extracted from a prospectively maintained database, which included the opinion of the originating pathologist (s) and the results from each Board member. Levels of agreement between the originating pathologist (s) and between the three EB pathologists were then assessed using kappa statistics. <h3>Results</h3> A total of 249 cases were analysed. In this period, the EB had an increase in referrals of 260%, from 20 in 2009 to 72 in 2013. Of the 249 cases, 200 (80.3%) demonstrated a EB three-way agreement, with a kappa score of 0.67, defined as substantial agreement. There were marked differences between the diagnoses of the originating pathologist (s) and the Board consensus; for instance a benign diagnosis was made in 30.6% of cases by the originating pathologist (s) compared with 80.3% by the EB. The overall local to EB kappa consensus score was 0.09, only just better than chance. Of the 131 submissions submitted with a definite diagnosis, 47% had their grading revised by the EB consensus. <h3>Conclusion</h3> This study demonstrates a dramatic increase in referrals to the BCSP EB in its first five years. The diagnosis of the originating pathologist (s) was often at odds with the EB consensus and yet the Board demonstrated very good levels of agreement. The establishment of the Board is one of many successful developments in pathology associated with the introduction of cancer screening programmes and demonstrates the importance of expert opinion in difficult pathological diagnostic areas. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Muto T, Bussey HJR, Morson BC. J Clin Pathol 1973; 26: 25–31 Shepherd NA, Griggs RKL. Mod Pathol2015; in press Loughrey MB, Shepherd NA. Histopathology 2015; 66: 66-77
Adult human megakaryocyte-erythroid progenitors are in the CD34+CD38mid fraction
Authors: Chad Sanada, Juliana Xavier-Ferrucio, Yi-Chien Lu, Elizabeth Min, Ping-Xia Zhang, Siying Zou, Elaine Kang, Meng Zhang, Gazelle Zerafati, Patrick G. Gallagher, Diane S. Krause
Journal: Blood (2016)
Soundings: Good news, and some bad
Authors: George Dunea
Journal: BMJ (2001)

It is a sad reflection on human nature that crimes, misdeeds, mishaps, and mistakes are generally more newsworthy than the deeds of good men. It is therefore gratifying to read in our local newspapers about two Polish doctors who, during the German occupation, simulated a typhus epidemic by injecting patients who had other fevers with a harmless bacterium that would yield a positive test for typhus. By frightening the Germans into quarantining some 12 villages and declaring them off limits, they saved thousands of people from death camps or slave labour. One of the doctors, now 87 years old, moved to Chicago in 1958 but only recently revealed this extraordinary story.

It is more difficult to sympathise with the efforts of health activists, however well intentioned, to stop the use of amalgam dental fillings and even have dentists remove those already inserted. Numerous studies have failed to substantiate claims that released mercury causes neurological and other complications. Some 100 million Americans have such fillings, which the American Dental Association has declared safe, yet arguments continue.

In Louisville, Kentucky, a 59 year old former Chicago schoolteacher appeared on television with an artificial heart implanted six weeks earlier for terminal heart failure. Occluding the opening of his tracheotomy tube each time he spoke, he said the operation was his only chance of survival. The heart felt heavy and took some getting used to, as it did not have a heartbeat but a constant whirring sound instead.

Also last month, Cleveland Clinic cardiologists warned about a possible increased risk of cardiovascular events in patients taking the COX 2 inhibitors celecoxib and rofecoxib. Elsewhere there are fears that the recent recall of cerivastatin may cause a backlash and make doctors less aggressive in lowering cholesterol levels—an effect possibly counterbalanced by a report that the sagging economy is causing people to eat out less frequently in restaurants. Chicago's Children's Memorial Hospital is offering to perform free of charge a stem cell transplant on a 12 year old illegal immigrant from Mexico who has leukaemia. And in Illinois, the prevalence of Lyme disease has doubled since 1999, spread by ticks feeding on deer and raccoons.
Two cases of infection with Bacillus anthracis, Romania, October 2011
Authors: R Popescu, A Pistol, L Miltaru, D Caplan, R Cucuiu, F Popovici
Journal: Eurosurveillance (2011)

A cluster of two confirmed cases of anthrax were reported in October 2011 from a small village with a population of 3,400 people, in south-eastern Romania.One was a fatal case of cutaneous and anthrax meningoencephalitis, while the other had cutaneous anthrax. Both cases had been exposed to one Bacillus anthracis-infected cow via consumption of its meat or being involved in its slaughter.
A rare case of cervical vertebral body osteoid osteoma.
Authors: S Bykov, I Garty, D Lumelsky, N Bor
Journal: Clinical Nuclear Medicine (2001)

BYKOV, SERGEY M.D.,*; GARTY, IZAK M.D.,*; LUMELSKY, DIMITRY M.D.†; BOR, NOAM M.D.‡ Author Information
Press: Wait until the morning after
Authors: J. Jones
Journal: BMJ (2001)

Journalists love stories with “legs”—the ones that run and run, colonising vast tracts of column inches in the letters and comment pages, not just news sections. The one about Levonelle (who dreams up these daft names?) has already shown strong enough form for inclusion in this highly prized category.

General practitioners will recognise the name, of course. To almost everyone else, it's the “morning after pill,” or any number of alternatives conceived to fit a headline or to ascribe a moral loading—the “next day” pill, the “day after” pill, an emergency contraceptive, and an abortion pill.

Nomenclature aside, why do we find the saga of the morning after pill so compelling? Well, the ingredients are guaranteed to stir our most raw emotions—fear, guilt, revulsion, and desire—in varying measure. There's illicit unprotected sex, for starters; fear of discovery and of accidental pregnancy; and a magic potion that makes unwanted embryos vanish—just like that. While that's bubbling away in …
Inhibition of the erythropoietin-induced erythroid differentiation by granulocyte-macrophage colony-stimulating factor in the human UT-7 cell line is not due to a negative regulation of the erythropoietin receptor
Authors: O Hermine, A Dubart, F Porteux, P Mayeux, M Titeux, D Dumenil, W Vainchenker
Journal: Blood (1996)
Cross-reactive antibody to swine influenza A(H3N2) subtype virus in children and adults before and after immunisation with 2010/11 trivalent inactivated influenza vaccine in Canada, August to November 2010
Authors: D M Skowronski, G De Serres, N Z Janjua, J L Gardy, V Gilca, M Dionne, M E Hamelin, C Rhéaume, G Boivin
Journal: Eurosurveillance (2012)

In pre- and post-immunisation sera from children (17-120 months-old) and adults (20-59 years-old) immunised with 2010/11 trivalent inactivated influenza vaccine, we assessed age-related patterns of sero-susceptibility and vaccine-induced cross-reactive antibodies to a representative swine H3N2 (swH3N2) and a related ancestral human H3N2 (A/Sydney/5/1997) influenza virus. Few children but a greater proportion of adults showed pre-immunisation haemagglutination inhibition titres ≥40 to either virus. Titres increased with age among children but decreased in adults. Fewer than 20% showed a four-fold rise in antibody titres to either virus following immunisation. Further investigation is warranted to guide ongoing risk assessment and response to emerging swine H3N2 viruses.
Arterial Bleeding as an Unusual Late Complication of Percutaneous Transhepatic Biliary Drainage
Authors: P.  Born, T.  Rösch, W.  Sandschin, W.  Weiss
Journal: Endoscopy (2003)

Percutaneous transhepatic biliary drainage (PTBD) is an established means of treating biliary disease after endoscopic retrograde cholangiopancreatography (ERCP) has failed [1]. Arterial bleeding from a PTBD tract is very uncommon as a late complication [2] [3] - in contrast to the early phase after PTBD placement, during which this may rarely occur [4] [5] [6]. We present here the case of a 74-year-old man with a 2-year history of malignant biliary stricture (Bismuth IV) who received treatment with a unilateral 16-Fr Yamakawa-type prosthesis to drain the right lobe of the liver. More than a year after the creation of the tract and after several uneventful exchanges of the Yamakawa-type prosthesis, the patient presented prior to schedule because of fever and an inability to flush the prosthesis. He also reported melena. Laboratory investigations showed an alkaline phosphatase level of 1291 U/l (normal range 60-180), γ-glutamyltransferase 394 U/l (normal range < 28), bilirubin 13.7 mg/dl (normal range < 1.2), and C-reactive protein 7.9 mg/dl (normal range < 0.5); leukocytes were normal.
Vaccine adjuvant therapy for colorectal cancer: "very dramatic" or ho-hum?
Authors: C G Moertel
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.3.385 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8445411 Vaccine adjuvant therapy for colorectal cancer: "very dramatic" or ho-hum? C G MoertelxC G MoertelSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.3.385 PDF "Vaccine adjuvant therapy for colorectal cancer: "very dramatic" or ho-hum?." Journal of Clinical Oncology, 11(3), pp. 385–386© 1993 by American Society of Clinical Oncology
Canadian Studies Aimed Toward a Less Harmful Cigarette&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: W. H. Cherry, Ph.D., W. F. Forbes, Ph.D., D.Sc.
Journal: JNCI Journal of the National Cancer Institute (1972)

Canadian Studies Aimed Toward a Less Harmful Cigarette Get access W. H. Cherry, Ph.D., W. H. Cherry, Ph.D. Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar W. F. Forbes, Ph.D., D.Sc. W. F. Forbes, Ph.D., D.Sc. Department of Statistics, University of Waterloo, Waterloo, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 48, Issue 6, June 1972, Pages 1765–1773, https://doi.org/10.1093/jnci/48.6.1765 Published: 01 June 1972
FRI0085 Comparison of the Disease Activity Score Using Erythrocyte Sedimentation Rate and C-Reactive Protein in Koreans with Rheumatoid Arthritis
Authors: K.M. Son, Y.I. Seo, H.A. Kim
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The disease activity scored based on 28 joints (DAS28) has been widely used in clinical practice and research studies of rheumatoid arthritis (RA). <h3>Objectives</h3> The objective of this study was to evaluate discordance between DAS28 based on erythrocyte sedimentation rate (ESR) versus C-reactive protein (CRP) in patients with RA. <h3>Methods</h3> From August to December 2011, 540 RA patients who visited 2 rheumatology clinics affiliated to Hallym University and had at least one DAS28 evaluation were examined. <h3>Results</h3> The mean age of the included patients was 53 years, and 82% were female. The mean duration of disease was 32.9±41.2 months. The mean DAS28-ESR was higher than DAS28-CRP (3.65 vs 3.44; p&lt;0.001). The number of patients who satisfied the criteria of remission was 126 (23.3%) in DAS28-ESR versus 134 (24.8%) in DAS28-CRP and the number of patients with high disease activity was 81 (15%) versus 44 (8.1%) for DAS28-ESR and DAS28-CRP. When DAS28-ESR and DAS-CRP were compared with regard to 4 disease activity categories, agreement with regard to DAS28 disease activity categories was observed in 344 (53.7%) with κ=0.45. The improvement of disease activity based on EULAR response in classifying patients EULAR responders using the two DAS28 definitions, there was 201 (71.7%) agreement with κ=0.665 between two methods. <h3>Conclusions</h3> There was discordance between the ESR based and CRP based DAS28, a situation that could affect clinical treatment decisions for RA patients. <h3>Disclosure of Interest</h3> None declared