IRON METABOLISM AND ITS RELATIONSHIP TO ANEMIA AND THERAPY
Authors: Willis M. Fowler, Adelaide P. Barer
Journal: Annals of Internal Medicine (1940)

Article1 September 1940IRON METABOLISM AND ITS RELATIONSHIP TO ANEMIA AND THERAPYWILLIS M. FOWLER, M.D., ADELAIDE P. BARER, PH.D.WILLIS M. FOWLER, M.D.Search for more papers by this author, ADELAIDE P. BARER, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-14-3-378 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIron, in the form of an inorganic salt, may be considered as a specific remedy for certain types of anemia and will produce results which are comparable to those obtained by liver extract in the treatment of pernicious anemia. The use of iron as an antianemic remedy is not new but the results which have been obtained in recent years are more striking than in the past and have served to focus attention on this metal. The increased popularity and the apparent increased effectiveness have been due primarily to the administration of adequate amounts of iron to properly selected cases...Bibliography1. BARERFOWLER APWM: The iron requirement of adults, Jr. Am. Dietet. Assoc. (In Press). Google Scholar2. FARRARGOLDHAMER GESM: The iron requirement of the normal human adult, Jr. Nutr., 1935, x, 241. CrossrefGoogle Scholar3. ELVEHJEMHARTSHERMAN CAEBWC: Availability of iron from different sources for hemoglobin formation, Jr. Biol. Chem., 1933, ciii, 61. CrossrefGoogle Scholar4. SHERMANELVEHJEMHART WCCAEB: Further studies on the availability of iron in biological materials, Jr. Biol. Chem., 1934, cvii, 383. CrossrefGoogle Scholar5. WIDDOWSONMCCANCE EMRA: Iron in human nutrition, Jr. Hyg., 1936, xxxvi, 13. CrossrefGoogle Scholar6. WITTS LJ: Simple achlorhydric anemia, Guy's Hosp. Rep., 1930, lxxx, 253. Google Scholar7. FABERGRAM KHC: Relations between gastric achylia and simple and pernicious anemia, Arch. Int. Med., 1924, xxxiv, 658. CrossrefGoogle Scholar8. WAUGH TR: Hypochromic anemia with achlorhydria, Arch. Int. Med., 1931, xlvii, 71. CrossrefGoogle Scholar9. WINTROBEBEEBE MMRT: Idiopathic hypochromic anemia, Medicine, 1933, xii, 187. CrossrefGoogle Scholar10. HEATHPATEK CWAJ: The anemia of iron deficiency, Medicine, 1937, xvi, 267. CrossrefGoogle Scholar11. BARERFOWLER APWM: Influence of gastric acidity and degree of anemia on iron retention, Arch. Int. Med., 1937, lix, 785. CrossrefGoogle Scholar12. BARERFOWLER APWM: The blood loss during normal menstruation, Am. Jr. Obst. and Gynec., 1936, xxxi, 979. CrossrefGoogle Scholar13. BARERFOWLER APWM: The blood loss in menorrhagia, Am. Jr. Obst. and Gynec., 1938, xxxv, 839. CrossrefGoogle Scholar14. BARERFOWLER APWM: Urinary iron excretion, Jr. Lab. and Clin. Med., 1937, xxiii, 148. Google Scholar15. CAMERERSOLDNER WF: Die chemische Zusammensetzung des Neugeborenen, Ztschr. f. Biol., 1930, xxxix, 179; 1900, xl, 529. Google Scholar16. STEARNS G: Mineral metabolism of normal infants, Physiol. Rev., 1939, xix, 415. CrossrefGoogle Scholar17. DAUPHINEE JA: The iron requirement in normal nutrition, Canad. Med. Assoc. Jr., 1938, xxxix, 483. Google Scholar18. STRAUSS MB: Chlorotic anemia of pregnancy, Am. Jr. Med. Sci., 1930, clxxx, 818. STRAUSS, M. B., and CASTLE, W. B.: Studies of anemia in pregnancy, Am. Jr. Med. Sci., 1933, clxxxv, 539. CrossrefGoogle Scholar19. FOWLERBARER WMAP: The etiology and treatment of idiopathic hypochromic anemia, Am. Jr. Med. Sci., 1937, cxciv, 625. CrossrefGoogle Scholar20. FOWLERBARER WMAP: The treatment of iron deficiency anemias, Jr. Am. Med. Assoc., 1939, cxii, 110. CrossrefGoogle Scholar21. MOOREARROWSMITHWELCHMINNICH CVWRJV: Studies in iron transportation and metabolism. IV. Observations on the absorption of iron from the gastrointestinal tract, Jr. Clin. Invest., 1939, xviii, 553. CrossrefGoogle Scholar22. FOWLERBARER WMAP: Retention and utilization of orally administered iron, Arch. Int. Med., 1937, lix, 561. CrossrefGoogle Scholar23. BROCKHUNTER JFD: The fate of large doses of iron administered by mouth, Quart. Jr. Med., 1937, vi, 5. Google Scholar24. REIMANN F: Die ferrosensiblen chronischen Chloranämien (Asiderosen) und die therapeutische Wirkung des Eisens bei diesen Anämien, Ztschr. f. klin. Med., 1933, cxxvi, 7. FRITSCH, F., and REIMANN, F.: Zur Wirkung des Eisens bei den eisenempfindlichen Anämien, Med. Klin., 1933, xxix, 728. Google Scholar25. FOWLERBARERSPIELHAGEN WMAPGF: Retention and utilization of small amounts of orally administered iron, Arch. Int. Med., 1937, lix, 1024. CrossrefGoogle Scholar26. BARERFOWLER APWM: Influence of copper and a liver fraction on retention of iron, Arch. Int. Med., 1937, lx, 474. CrossrefGoogle Scholar27. FOWLERBARER WMAP: Retention and utilization of parenterally administered iron, Arch. Int. Med., 1937, lx, 967. CrossrefGoogle Scholar28. HEATH CW: Oral administration of iron in hypochromic anemia, Arch. Int. Med., 1933, li, 459. CrossrefGoogle Scholar29. WITTS LJ: Discussion on the treatment of the anemias, Proc. Roy. Soc. Med., 1933, xxvi, 607. Google Scholar30. BROCK JF: The relation between the hypochromic anemias and iron deficiency, Brit. Med. Jr., 1937, i, 314. CrossrefGoogle Scholar31. WHIPPLEROBSCHEIT-ROBBINS GHFS: Blood regeneration in severe anemia: optimum iron therapy and salt effect, Am. Jr. Physiol., 1930, xcii, 362. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Iowa City, Iowa*Received for publication March 18, 1940.From the Department of Internal Medicine, State University of Iowa, College of Medicine, Iowa City, Iowa.†A complete survey of the literature on the subject of iron requirements is given in reference1. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin C, Gastritis, and Gastric Disease: A Historical Review and UpdateLiteraturverzeichnis. 1 September 1940Volume 14, Issue 3Page: 378-386KeywordsAnemiaLiverPernicious anemiaSalts ePublished: 1 December 2008 Issue Published: 1 September 1940 PDF downloadLoading ...