tbuckley/cabot-search huggingface dataset:
MTX clearance is more important for intermediate-risk ALL.
Authors: W E Evans, M J Schell, C H Pui
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.6.1115 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2348226 MTX clearance is more important for intermediate-risk ALL. W E EvansxW E EvansSearch for articles by this author , M J SchellxM J SchellSearch for articles by this author , C H PuixC H PuiSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.6.1115 PDF "MTX clearance is more important for intermediate-risk ALL.." Journal of Clinical Oncology, 8(6), pp. 1115–1116© 1990 by American Society of Clinical Oncology
AB0368 Association of 25-Hydroxyvitamin D3 Serum Levels and Metabolic Parameters in Portuguese Patients with Established Rheumatoid Arthritis
Authors: M. Bernardes, M.J. Martins, D. Rosa-Gonçalves, R. Fonseca, P. Madureira, R. Vieira, F. Aguiar, F. Simões-Ventura, L. Costa
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objective:</h3> To determine the effect of sleeping position on the lung function of prematurely born infants when post term, whether any effect was similar to that before discharge from the neonatal unit, and if it differed according to bronchopulmonary (BPD) status. <h3>Design:</h3> Prospective study. <h3>Setting:</h3> Tertiary neonatal unit. <h3>Patients:</h3> Twenty infants, median gestational age 30 weeks (range 25–32); 10 had BPD. <h3>Interventions:</h3> Before neonatal unit discharge (median age 36 weeks postmenstrual age (PMA)) and when post term, infants were studied prone and supine, each position maintained for 3 h. <h3>Main outcome measures:</h3> Oxygen saturation was monitored continuously and, at the end of each 3 h period, functional residual capacity (FRC) and compliance (CRS) and resistance (RRS) of the respiratory system were measured. <h3>Results:</h3> At a median of 36 weeks PMA and 6 weeks later (post term), respectively, oxygen saturation (98% vs 96%, p = 0.001; 98% vs 97%, p = 0.011), FRC (26 vs 24 ml/kg, p&lt;0.0001; 35 vs 31 ml/kg, p = 0.001) and CRS (3.0 vs 2.4 ml/cm H<sub>2</sub>O, p = 0.034; 3.7 vs 2.5 ml/cm H<sub>2</sub>O, p = 0.015) were higher in the prone than the supine position. In the prone position, both BPD and non-BPD infants had significantly greater FRCs on both occasions and oxygen saturation at 36 weeks PMA, but oxygen saturation was significantly better post term only in non-BPD infants. Twelve infants had superior oxygen saturation and 17 superior FRCs in the prone compared with the supine position at both 36 weeks PMA and post term. <h3>Conclusions:</h3> These results suggest that lung function impairment does not explain why prematurely born infants are at increased risk of sudden infant death syndrome in the prone compared with the supine position.
Abstract 18331: Transcatheter Aortic Valve Implantation: Results with Noncompetitive Decision Making for Transfemoral or Transapical Approach
Authors: Ralf Seipelt, Bernd Danner, Cornelius Jakobshagen, Gerd-Gunnar Hanekop, Tanja Viel, Gerd Hasenfuss, Friedrich A Schoendube, Wolfgang Schillinger
Journal: Circulation (2010)
Authors’ reply to De Schryver and colleagues
Authors: C Y William Tong, Anna Riddell, Ioana Kennedy
Journal: BMJ (2015)

De Schryver and colleagues raise issues about the hepatitis B vaccination course and the antibody level used to indicate immunity.1 2

Our algorithm was adapted from the UK “Green Book” on immunisation against infectious diseases,3 and it stratified risk on the basis of potential immunity to hepatitis B virus. The primary course of hepatitis B vaccination is three …
Airway Memory CD4 + T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses
Authors: Jincun Zhao, Jingxian Zhao, Ashutosh K. Mangalam, Rudragouda Channappanavar, Craig Fett, David K. Meyerholz, Sudhakar Agnihothram, Ralph S. Baric, Chella S. David, Stanley Perlman
Journal: Immunity (2016)
Prevalence of clinically significant depressive symptoms in black and white patients in family practice settings
Authors: W W Zung, J MacDonald, E M Zung
Journal: American Journal of Psychiatry (1988)

The authors administered the Zung Self-Rating Depression Scale to 764 black and 773 white adult outpatients in primary care settings. There was no significant difference between the races in prevalence of depressive symptoms or distribution of symptom severity levels.
Psychiatric Symptomatology Among Hospitalized Cancer Patients
Authors: Thomas J. Craig, Martin D. Abeloff
Journal: American Journal of Psychiatry (1974)

A 90-item symptom checklist (SCL-90) was administered to 30 patients admitted consecutively to an oncology research unit. More than half of the patients showed moderate to high levels of depression, and 30 percent had elevated levels of anxiety. Nearly one-fourth had overall symptom patterns virtually identical to those seen in patients admitted to an emergency psychiatric service. The authors state that the use of this kind ofself administered symptom inventory can be a valuable adjunct to the identification and management of psychiatric pathology in cancer patients.
The clinical significance of neutrophil-lymphocyte ratio versus platelet-lymphocyte ratio in patients with metastatic gastric cancer.
Authors: Suee Lee, Sung Yong Oh, Hyuk-Chan Kwon, Sung-Hyun Kim, Ji Hyun Lee, Min Chan Kim, Ki-Han Kim, Hyo-Jin Kim
Journal: Journal of Clinical Oncology (2012)

e14686 Background: Several inflammatory response materials could be biomarkers for prediction of prognosis of cancer patients. The neutrophil/lymphocyte ratio (NLR), and the platelet/lymphocyte ratio (PLR) has been introduced for prognostic scoring system in several cancer. The objective of this study was to determine whether the neutrophil-lymphocyte ratio (NLR), or the platelet-lymphocyte ratio (PLR) are significant prognostic marker in metastatic gastric cancer. Methods: We analyzed 150 patients with metastatic gastric cancer who received mFOLFOX regimen as the first-line chemotherapy. The NLR and PLR were calculated from complete blood counts in baseline laboratory test before the first cycle chemotherapy. Results: The overall response rate was 34.7% and stable disease was 38.7%. The median progression-free survival (PFS) was 4.2 months (95% CI, 3.5-4.8 months) and the median overall survival (OS) was 13.1 months (95% CI, 10.6-15.5 months). Kaplan-Meier analysis and log-rank test revealed that higher NLR (≥3) was a good prognostic biomarker of OS (p=0.024), but not associated with PFS (p=0.838). The PLR was not associated with PFS and OS (p=0.373 and p=0.304, respectively). In Cox regression analysis for predicting OS, younger age, good performance status, response of chemotherapy, and lower NLR (&lt;3) were independent prognostic markers (Hazard ratio 2.052, 95% CI 1.370-3.075, p&lt;0.001, hazard ratio 8.467, 95% CI 1.937-37.017, p=0.005, hazard ratio 1.889, 95% CI 1.222-2.921, p=0.004, and hazard ratio 1.616, 95% CI 1.080-2.416, p=0.019, respectively). Conclusions: Although prognosis in metastatic gastric cancer was associated with age and performance status, the NLR might be simple and prognostic index for metastatic gastric cancer.
PWE-186 Use of dna ploidy in routine pathology practice as a biomarker for barrett’s oesophagus with high risk clinical features: Abstract PWE-186 Table 1
Authors: JM Dunn, F Chang, M Novelli, EW Odell
Journal: Gut (2015)

<h3>Introduction</h3> Barrett’s oesophagus (BE) is considered to be associated with an increased risk of esophageal adenocarcinoma (OAC), but the risk of progression is low and unpredictable. Previous studies have demonstrated a higher risk of progression in BE patients with: low grade dysplasia; segment length &gt;8 cm; a family history of OAC and residual BE post treatment for OAC (surgery, chemoradiotherapy or endoscopic therapy). We and others have previously demonstrated that DNA ploidy abnormalities can act as prognostic biomarkers for the risk of progression to OAC. The aim of this study was to assess DNA ploidy in high risk groups using routine biopsy samples taken at surveillance endoscopy in a clinical setting. <h3>Method</h3> Prospective study of patients undergoing routine BE surveillance at three centres. All biopsy samples were dual reported by two expert pathologists. DNA ploidy analysis was undertaken using Image cytometry (ICM) on Formalin Fixed Paraffin Embedded tissue, as previously described.<sup>1</sup>All samples were analysed to the same protocol. <h3>Results</h3> A total of 51 patients underwent DNA ploidy analysis over a 2 year period. Mean age was 63 years (range 22–86 years), 82% male. Results are shown in Table 1. There was high prevalence of DNA ploidy abnormalities (aneuploidy) in the LGD group at 33%. DNA ploidy abnormalities were not identified in other groups on this study. <h3>Conclusion</h3> This study demonstrates the presence of aneuploidy is significantly higher in low grade dysplasia than other high risk clinical groups, with a third of patients displaying genomic instability. DNA ploidy ICM may be useful in routine pathology practice to risk stratify patients with LGD. The role of DNA ploidy in non dysplastic BE with high clinical risk cannot be concluded from this small cohort. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Dunn JM, Mackenzie GD, Oukrif D, <i><i>et al</i>.</i>Image cytometry accurately detects DNA ploidy abnormalities and predicts late relapse to high grade dysplasia and adenocarcinoma in Barrett–s oesophagus following photodynamic therapy. <i>Br J Cancer</i>2010;<b>102</b>:1608–1617
SAT0288 Atypical Femoral Fractures After Treatment with Bisphosphonates and Denosumab in Inflammatory and Senile Osteoporosis
Authors: L. Merino Meléndez, I. Llorente, E. García, R. García-Vicuña, S. Castañeda Sanz
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Atypical femoral fractures (AFF) are an infrequent side-effect of the antiosteoporotic treatment with bisphosphonates (around 5/10,000 patients/year). AFF usually occur at sites suffering of tensional stress, such as the subtrochanteric or diaphyseal femur. The pathogenic mechanism is not well known. Bisphosphonates (BPs) inhibit osteoclast activity and reduce bone remodelling, leading to a loss of the auto-repair bone tissue capacity and causing effects that can contribute to AFF. Denosumab (Dmab) is a monoclonal antibody, which blocks the receptor activator of nuclear factor kappa-B ligand (RANKL). Dmab inhibits the differentiation, proliferation, activity and survival of the osteoclasts, provoking an interruption in the "targeted remodelling" process, making microcracks develop. Although it is considered an efficacious treatment for osteoporosis (OP), its side-effects and possible chronic toxicity are still yet not well understood. <h3>Objectives</h3> We report two cases of AFF just a few months after starting treatment with Dmab. <h3>Methods</h3> Case 1. 73 year-old woman diagnosed of adult polymyositis anti-Jo1+, who was under treatment with prednisone 5 mg/day for a long time (10 years), methotrexate, cyclosporine A, and proton pump inhibitors (PPI). She had suffered two vertebral fractures (T9, L1), and a right isquiopubian branch fracture and she went under treatment with risedronate for 6 years and with strontium ranelate for another 5. Afterwards, she started Dmab and after her second dose, she suffered an AFF without prodromic symptoms neither recognizable triggers. Case 2. 82 year-old woman with polymyalgia rheumatica, that followed treatment with oral prednisone (5-10 mg/day) and inhalated glucocorticoids (due to asthma) for a long time, and omeprazole for more than 10 years. After treatment with oral BPs (etidronate, alendronate, ibandronate, risedronate) for more than 15 years, she started Dmab, and also after the second dose she suffered an AFF. <h3>Results</h3> We present here two cases with systemic chronic inflammatory diseases that were under lengthy treatments with corticosteroids, PPI and BPs, who suffered AFF after introducing Dmab. In both cases, a delay in the consolidation process of both of the fractures was observed, but the exact contribution of Dmab in this delay is truly uncertain. <h3>Conclusions</h3> Our case reports support the fact that the consecutive use of different antirresorptive therapies should possibly be avoided (even though they had different mechanisms of action) in patients that need lengthy treatments for OP, specially if they also have other risk factors for AFF (advanced age, chronic glucocorticoid use or underlying inflammatory illnesses). <h3>Disclosure of Interest</h3> None declared
SAT0280 Relationship of Atherosclerosis of Coronary and Extracranial Arteries and Mineral Bone Density Among Men
Authors: A. Voronkina, E. Malyuta, P. Korchuganov, T. Raskina, O. Barbarash, A. Kokov, A. Novitskaya
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To rate severity of lesions of extracranial and coronary arteries, depending on the bone mineral density (BMD) among men with coronary heart disease (CHD). <h3>Methods</h3> 111 men aged 50-75 years [60 (55; 65) years old] with verified CHD were examined. By dual-energy absorptiometry at the femoral neck and lumbar spine BMD and the index T-criterion were measured. All patients were given coronary angiography (CAG) and quantification of coronary calcium using multislice computed tomography. Calcium index was determined by the Agatston method. Options for the defeat coronary arteries (CA) of one-, two-, and three-vessel and combination with the defeat of the trunk of the left CA (TrLCA) were evaluated. The intima-media thickness (IMT) was investigated according to duplex scanning of the extracranial arteries. Hemodynamically was significant narrowing of more than 50% of the diameter of the artery. Depending on the values of the T-criterion, patients were divided into 2 groups: I - with osteopenic syndrome (90 patients), aged 61 (55; 65) years old; II - with normal BMD (21 patients), aged 59 (55; 65) years old. According to the CAG isolated group of patients with severe lesions (stenosis of three CA and/or TrLCA) – type A and with stenosis of 1 or 2 CA - type B. <h3>Results</h3> Osteopenic syndrome among men with CHD was detected in 81,1% of cases. IMT more than 1,0 mm identify 75,5% in group I and 66,7% in group II, p&gt;0,05. Stenosis of more than 50% were detected at 56,7% in the 1st group and 38,1% of patients in group II, p&gt;0,05. The marked negative correlation is between IMT and T-criterion of femur (r= -0,21; p=0,0299), and BMD of proximal femur (r= -0,2; p=0,0348). A significant positive correlation is between the number of diseased coronary arteries and IMT (r=0,3; p=0,0017). The values of total calcium score totaled 613,8 (256,8; 1097), 152.8 (0; 702,4), respectively, in groups I and II, with significant differences between groups I and II (p=0,0043). Indicator calcium score was significantly correlated with the number of diseased coronary arteries (r=0,24; p=0,0134). Severe coronary lesions (type A) was detected with 58 patients in group I (64,4%), 11 - in group II (52,4%), p&gt;0,05. The values of total calcium score in type B among patients with normal BMD were significantly lower in comparison with a group of osteopenic syndrome and amounted to 0 (0; 152,8) and 768 (122,8; 1129,5), respectively (p=0,0041). <h3>Conclusions</h3> Reduced bone mineral density among men correlates with atherosclerotic lesions of the extracranial arteries and is associated with calcification of the coronary arteries, which confirms the relationship between the osteopenic syndrome, atherosclerosis and vascular calcification with males. <h3>Disclosure of Interest</h3> None declared
The Cytology of the Gastric Fluid in the Diagnosis of Carcinoma of the Stomach&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: George N. Papanicolaou, M. D. and Ph. D., William A. Cooper, M. D.
Journal: JNCI Journal of the National Cancer Institute (1947)

The Cytology of the Gastric Fluid in the Diagnosis of Carcinoma of the Stomach George N. Papanicolaou, M. D. and Ph. D., George N. Papanicolaou, M. D. and Ph. D. Lewiss Cass Ledyard, Jr., Fellow, Cornell University Medical College and the New York Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar William A. Cooper, M. D. William A. Cooper, M. D. Lewiss Cass Ledyard, Jr., Fellow, Cornell University Medical College and the New York Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 357–360, https://doi.org/10.1093/jnci/7.5.357 Published: 01 April 1947
PTH-198 Preoperative parenteral nutrition in crohn’s disease patients requiring abdominal surgery
Authors: J Le Couteur, K Patel, S O’Sullivan, C Ferreira, AB Williams, AA Darakhshan, PM Irving, JD Sanderson, M McCarthy, J Dunn
Journal: Gut (2015)

<h3>Introduction</h3> The benefits of parenteral nutrition (PN) in Crohn's Disease (CD) prior to abdominal surgery remains debatable, with two recent studies suggesting preoperative PN given to patients with moderate to severe CD minimises the risk of early postoperative complications. <h3>Method</h3> Retrospective cohort study of consecutive CD patients who received PN prior to abdominal surgery, from January 2013 to January 2015. Total days of PN received prior to surgery, changes in weight and BMI, and changes to CRP and albumin in all patients receiving PN were analysed. Adverse events related to PN, including line-related complications, and post-operative complications were also recorded. <h3>Results</h3> Of 62 operations performed for CD over the study period, 6 patients (4 male) received pre-operative PN. PN was administered via a PICC line with a dedicated lumen in all patients. All patients continued PO liquid intake and existing CD medications. 5 patients had stricturing and penetrating disease (3 with ileocaecal disease, and 2 with colonic disease). 2 of these patients had phlegmons, 2 had complex peri-anal fistulising disease, and 1 had a high output entero-cutaneous fistula. A further patient had isolated ileocolic stricturing disease. 4 patients required ileocaecal resection, 1 required panproctocolectomy and 1 sub-total colectomy. Pre-operative PN was administered for a mean of 41 days. Weight and BMI increased in all 6 patients (mean weight increased from 51.2 kg to 57.7 kg, mean BMI from 17.5 kg/m<sup>2</sup>to 19.8 kg/m<sup>2</sup>). The weight gained was maintained at routine follow-up after surgery. Mean CRP improved from 35.5 to 18.3, and albumin from 35.5 g/L to 38.3 g/L. Mean post-operative stay was 12 days, and diversion stoma was not required in 80% (4 patients). Line complications (catheter related infection/thrombosis) were not seen. One patient (16.7%) required PN withdrawal 2 days before planned surgery for suspected line sepsis not confirmed on blood cultures. No serious post-operative complications occurred, and only a single patient required antibiotics post-operatively for a small collection (not requiring surgical or radiological intervention). <h3>Conclusion</h3> In this small group of complex CD patients who received pre-operative PN, sustained weight gain and improvement in inflammatory markers was observed. Two recent studies suggest favourable postoperative outcomes, and our findings are in keeping with this. The role of optimisation with PN warrants further investigation and randomised controlled studies are required. <h3>Disclosure of interest</h3> None Declared.
Treatement of excessive weight gain in patients taking lithium
Authors: M Dempsey, D L Dunner, R R Fieve, T Farkas, J Wong
Journal: American Journal of Psychiatry (1976)

Six female primary affective disorder patients who had gained an average of 9.5 kg while taking lithium lost an average of 2.9 kg on a 10-day 900 calorie a day hospital diet containing 100 mEq of sodium per day. No evidence of lithium toxicity was observed on this regimen. There was no evidence that fluid retention played a major role in the weight gain.
In-111 leukocyte accumulation in aberrant bone marrow after spinal fusion mimicking paraspinal infection.
Authors: DWIGHT ACHONG, LUIS TENORIO
Journal: Clinical Nuclear Medicine (2001)

From the Nuclear Medicine Service, James A. Haley Veterans’ Hospital, and the University of South Florida School of Medicine, Tampa, Florida Received for publication August 16, 2000. Accepted November 6, 2000. Reprint requests: Dwight M. Achong, Nuclear Medicine (115), James A. Haley Veterans’ Hospital, 13000 Bruce B. Downs Boulevard, Tampa, Florida 33612. E-mail: [email protected]
Randomized trials in the treatment of cancer of the esophagus.
Authors: D J Girling, P I Clark
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.7.1031 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1607910 Randomized trials in the treatment of cancer of the esophagus. D J GirlingxD J GirlingSearch for articles by this author , P I ClarkxP I ClarkSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.7.1031 First Page PDF © 1992 by American Society of Clinical Oncology
Striatin Is a Novel Regulator Of Aldosterone-Mediated Endothelial Cell Activation
Authors: Enrique D. Machado-Fiallo, Christopher Vega, Arelys Ramos-Rivera, Josue A. Benabe-Carlo, Gregory N. Prado, Luminita H. Pojoga, Alicia Rivera, Jose R. Romero
Journal: Blood (2013)
The Pathology of Gastric Carcinoma in Mice
Authors: Elsie McPeak, M. D., Shields Warren, M. D.
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article The Pathology of Gastric Carcinoma in Mice Get access Elsie McPeak, M. D., Elsie McPeak, M. D. New England Deaconess Hospital, Boston Search for other works by this author on: Oxford Academic PubMed Google Scholar Shields Warren, M. D. Shields Warren, M. D. New England Deaconess Hospital, Boston Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 309–311, https://doi.org/10.1093/jnci/7.5.309 Published: 01 April 1947
Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee
Authors: Raif S. Geha, Luigi D. Notarangelo, Jean-Laurent Casanova, Helen Chapel, Mary Ellen Conley, Alain Fischer, Lennart Hammarström, Shigeaki Nonoyama, Hans D. Ochs, Jennifer M. Puck, Chaim Roifman, Reinhard Seger, Josiah Wedgwood
Journal: Journal of Allergy and Clinical Immunology (2007)
Roads Diverge — A Robert Frost View of Leukemia Development
Authors: Aaron D. Viny, Ross L. Levine
Journal: New England Journal of Medicine (2016)

Genomic studies have increased our understanding of the genetic basis for human cancers, including myeloid leukemias. In the past 5 years, our knowledge of the effect of key driver mutations has expanded and molecular genetic testing has become a mainstay of acute myeloid leukemia (AML) diagnosis and risk stratification and a guide for postremission therapy.1 However, our understanding of the ways in which various combinations of mutations can cooperate to induce the development of leukemia remains incomplete. In this issue of the Journal, Papaemmanuil and colleagues2 provide practice-changing insights that redefine molecular classification of AML and elucidate a deeper understanding . . .