tbuckley/cabot-search huggingface dataset:
New and Highly Efficient Therapy for Treatment NPM-ALK Associated Lymphomas
Authors: Lukas Kenner, Daniela Laimer, Helmut Dolznig, Paul Vesely, Karoline Kollmann, Ana-Iris Iris Schiefer, Veronika Sexl, Philipp B Staber, Gerald Hoefler, Josef Penninger, Giorgio Inghirami, Jaeger Ulrich
Journal: Blood (2011)
Expressions of the CagA protein and CagA-signaling molecules predict Helicobacter pylori dependence of early-stage gastric DLBCL
Authors: Sung-Hsin Kuo, Li-Tzong Chen, Chung-Wu Lin, Kun-Huei Yeh, Chia-Tung Shun, Yi-Shin Tzeng, Jyh-Ming Liou, Ming-Shiang Wu, Ping-Ning Hsu, Ann-Lii Cheng
Journal: Blood (2016)
Genistein Promotes Apoptosis, Differentiation and Cell Cycle Arrest in All Trans Retinoic Acid (ATRA) Sensitive and Resistant Acute Promyelocytic Leukemia Cells.
Authors: Matiullah Khan, Angela Ping Ping Ng, Shen Jing, Chien-Shing Chen, Shunsuke Ishii
Journal: Blood (2004)
Phase I Clinical Trial of Haplotype Mismatched Myeloablative Stem Cell Transplantation: Higher Doses of Donor Lymphocyte Infusions Depleted of Alloreactive Cells Using ATIR May Improve Outcome without Causing GVHD.
Authors: Denis-Claude Roy, Sandra Cohen, Lambert Busque, Douglas Fish, Thomas Kiss, Silvy Lachance, Guy Sauvageau, Pierre Caudrelier, Jean Roy
Journal: Blood (2007)
Abstract 3347: Radiation-induced gastrointestinal (GI) syndrome as a function of age
Authors: Hongyan Li, Herman Kucharavy, Carla Hajj, Guoqiang Hua, Ryan Glass, Zhaoshi Zeng, Zvi Fuks, Philip B. Paty, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman
Journal: Cancer Research (2015)

Abstract The incidence of cancer increases with age and is generally thought to be an age-related disease. In prior studies we model tumor response to radiation therapy (RT) by studying its effect on normal tissue damage. We showed that RT-induced gastrointestinal (GI) syndrome represents coupled damage to intestine's micovasculature and the parenchymal epithelial cells. In addition, we showed that 15Gy irradiation is a lethal dose 100 for C57Bl6 mice treated with whole body irradiation (WBI) as it induces apoptosis in endothelial cells (EC) and initiates the GI syndrome in the small intestine. Our objective is to determine whether the microvasculature and/or the cycling crypt base columnar cells (CBCs), the small intestine stem cells, in an aging population (29 months mice, approx. 69 years in humans) are more sensitive to radiation effects than in young adults (3 months mice, approx. 20 years old human) with regards to normal tissue toxicity. Radiation-induced premature senescence and apoptosis were evaluated in EC and in CBCs in old mice versus young adult mice. Our results show enhanced endothelial apoptosis in crypts of older mice compared to young adult mice. There was a higher death rate in older versus young adult mice due to radiation-induced GI syndrome (90% vs 40% at 14Gy and 100% vs 60% at 15Gy). Crypt microcolony survival assays showed that 29 months-old mice had a lower number of regenerating crypts in all three doses tested (13Gy, 14Gy, 15Gy). In addition, there was an increase in CBC senescence in older mice compared to young adult mice. Therefore, microvasculature damage and an increase in CBCs apoptosis and senescence are the main events contributing to the enhanced rate of development of the RT-induced GI syndrome in the older mice. Ongoing studies are testing whether there is more senescence in the endothelial cells in older mice than in the mature adults, and if RT enhances senescence in these cells in older vs younger adult mice. These studies will be extended to include animals with various cancer burdens to explore the role of age in the efficacy of radiation treatment. Citation Format: Hongyan Li, Herman Kucharavy, Carla Hajj, Guoqiang Hua, Ryan Glass, Zhaoshi Zeng, Zvi Fuks, Philip B. Paty, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman. Radiation-induced gastrointestinal (GI) syndrome as a function of age. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3347. doi:10.1158/1538-7445.AM2015-3347
Effect of cardiac resynchronization therapy in patients with diabetes randomized in <scp>EchoCRT</scp>
Authors: Matthias P. Nägele, Jan Steffel, Michele Robertson, Jagmeet P. Singh, Andreas J. Flammer, Jeroen J. Bax, Jeffrey S. Borer, Kenneth Dickstein, Ian Ford, John Gorcsan, Daniel Gras, Henry Krum, Peter Sogaard, Johannes Holzmeister, William T. Abraham, Josep Brugada, Frank Ruschitzka
Journal: European Journal of Heart Failure (2016)
The Adhesion of Sickle Cell Disease Neutrophils to Endothelial Layers, In Vitro, Is Mediated by the Mac-1, LFA-1 and VLA-4 Integrins.
Authors: Andreia A. Canalli, Renata F. Proenca, Sara T.O. Saad, Nicola Conran, Fernando F. Costa
Journal: Blood (2007)
Autologous Stem Cell Transplantation (ASCT) Versus Standard Treatments for CLL Patients: First Interim Analysis of a Prospective Randomized Study from the French Cooperative Study Group on CLL.
Authors: Laurent Sutton, Marine Diviné, Philippe Travade, Claude Martin, Stéphane Leprêtre, Hugo Gonzalez, Eric Van den Neste, Mauricette Michallet, Florence Cymbalista, Frédéric Maloisel, Véronique Leblond, Houchingue Eghbali, Michel Berthout, Didier Decaudin, Brigitte Dreyfus, Bruno Cazin, Krimo Bouabdallah, Anne Drihème Pharm, Hélène Merle-Béral, Michel Leporrier
Journal: Blood (2005)
Effects of Impaired Fibrinopeptide A Cleavage on Fibrin Clot Structure: Studies with an Aα R16C Dysfibrinogen.
Authors: Veronica H. Flood, Chandrasekaran Nagaswami, Irina N. Chernysh, Hamid A. Al-Mondhiry, John W. Weisel, David H. Farrell
Journal: Blood (2006)
LEF-1 Regulates C/EBP α Expression and Neutrophil Differentiation in Normal Myelopoiesis and Congenital Neutropenia by a β-Catenin Independent Mechanism.
Authors: Julia Skokowa, Murat Uenalan, Axel Schambach, Michaela Scherr, Matthias Eder, Cornelia Zeidler, Christopher Baum, Martin Stanulla, Gunnar Cario, Karl Welte
Journal: Blood (2006)
Reduced Intensity Conditioning Regimens Do Not Offer a Survival Advantage to Myeloma Patients Receiving Allogeneic Stem Cell Hematopoietic Transplantation: A Societe Française De Greffe De Moelle Et De Therapie Cellulaire (SFGM-TC) Registry Study,
Authors: Yvan Beaussant, Etienne Daguindau, Aurore Vivot, Mohamad Mothy, Herve Avet-Loiseau, Damien Roos-Weil, Mauricette Michallet, Nicole Raus, Didier Blaise, Stephane Vigouroux, Agnes Buzyn, Gérard Socié, Nathalie Fegueux, Frederic Garban, Eric Deconinck
Journal: Blood (2011)
Recurrent Retroviral Vector Integration at the MDS1-EVI1 Locus in Rhesus Long-Term Repopulating Hematopoietic Stem Cells.
Authors: Boris Calmels, Cole Ferguson, Rima Adler, Stephanie Sellers, Mikko Laukkanen, Peiman Hematti, Robert Donahue, Cynthia Dunbar
Journal: Blood (2004)
Coordination‐Induced Assembly of Intelligent Polysaccharide‐Based Phototherapeutic Nanoparticles for Cancer Treatment
Authors: Ye Tian, Ranran Guo, Yajun Wang, Wuli Yang
Journal: Advanced Healthcare Materials (2016)

Smart polysaccharide-based anticancer phototherapeutic nanoparticles are prepared via a coordination-induced assembly process. Upon irradiated with a near infrared laser, the nanoparticles are not only able to simultaneously generate reactive oxygen species and hyperthermia that ablate tumors, but also possess tumor microenvironment-responsive off/on near infrared fluorescence and enhancement in photothermal effect, making them promising theranostic platform of cancer. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
THU0350 Morphological Alteration of The Retinal Posterior Pole and Functional Eye Impairment in Patients Affected by Systemic Lupus Erythematous and Sjögren Syndrome
Authors: P. Conigliaro, C. Canofari, G. Draghessi, P. Triggianese, C. Valeri, L. Novelli, G. Aloe, M. Cesareo, R. Perricone
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic Lupus Erythematous (SLE) and Sjögren Syndrome (SS) are autoimmune diseases that may exhibit several manifestations including an ocular involvement. Ocular involvement may be underestimated or be subclinical since current treatments as hydroxycloroquine and steroid may exert both beneficial and side effects on eyes. <h3>Objectives</h3> To assess the eye involvement in patients affected by autoimmune diseases as SLE and SS. <h3>Methods</h3> 48 patients affected by autoimmune diseases (29 SLE, 19 SS) without an active eye involvement were prospectively and consecutively enrolled. Morphological and functional eye assessment included: complete ophthalmogical examination, Spectral Domain Optical Coherence Tomography examination, fundus perimetry (FP), standard automated perimetry (SAP). 25 age and sex-matched healthy controls (HC) were also evaluated. <h3>Results</h3> SS patients displayed a reduction of mean retinal thickness in the posterior pole compared with HC and SLE (p=0.0003 and p=0.03, Fig.1A). This reduction was demonstrated in superior and inferior hemifield compared with HC (p=0.001 and p=0.007) and in superior hemifield compared with SLE (p=0.01) (Fig.1B-C). The FP mean differential sensitivity in SLE and SS patients was reduced compared with HC (p&lt;0.0001 and p=0.001, Fig.1D). The FP mean defect values in SLE and SS patients were higher than HC (p&lt;0.0001 and p=0.03, Fig.1E). A negative correlation was demonstrated in SLE between age and FP mean differential sensitivity (p=0.0005, r= -0.7). FP alteration in SLE was prevalent in those patients that were not on steroid treatment. In SS a higher proportion of patients with alteration in FP received a cumulative hydroxycloroquine dose higher than 1000g (p=0.02). The SAP demonstrated in SLE and SS patients a significant increase of the mean defect (MD) and the pattern standard deviation (PSD) compared with HC (MD: p=0.001 and p=0.01, PSD: p=0.02 and p=0.0002; Fig.1F-G). Visual field index (VFI) values were reduced in both SLE and SS patients compared with HC (p&lt;0.0001 for both comparisons, Fig.1H). SLE patients with kidney involvement displayed a significant increase of the MD and the PSD compared with those without kidney involvement (p=0.04 and p=0.01, respectively). Likewise, VFI values were reduced in SLE with nephritis compared with that in patients without a kidney involvement (p=0.04). <h3>Conclusions</h3> In a small cohort of patients with autoimmune diseases without an overt active eye involvement a morphological alteration of the retinal posterior pole and functional impairment was demonstrated suggesting a subclinical involvement thatmight be concealed by the treatment. <h3>Disclosure of Interest</h3> None declared
Quality of Life Scores Have a Prognostic Significance In Elderly AML Patients.
Authors: Esther Natalie Oliva, Roberto Latagliata, Giorgina Specchia, Francesca Ronco, Giuliana Alimena, Domenico Pastore, Stella Impera, Patrizia Guglielmo, Ida Carmosino, Iolanda Vincelli, Caterina Alati, Massimo Breccia, Laura Napoleone, Francesco Nobile
Journal: Blood (2008)
OC-084 Colonic Motor Responses to a Meal and To Bisacodyl and Sensations Evaluated During High-Resolution Manometry (HRM) Differ Between Laxative-Refractory Slow Transit Constipation With or Without Pain
Authors: M Corsetti, A Thys, T Vanuytsel, I Demedts, E Deloose, A Wolthuis, A D’Hoore, J Tack
Journal: Gut (2016)

<h3>Introduction</h3> In clinical practice colonic manometry is recommended to exclude colonic inertia (no response to meal and to drug stimulation, i.e. bisacodyl) in patients with slow transit laxative-refractory constipation (Bharucha 2013). As to date, this has not been assessed by colonic HRM in adults, our <i>aim</i>was to evaluate the sensations and colonic motor response to a meal and to bisacodyl in patients with slow-transit laxative-refractory constipation. <h3>Methods</h3> Consecutive patients with slow-transit and laxative-refractory Rome III constipation were enrolled. During colonoscopy, an HRM catheter (40 sensors, 2.5 cm spaced) and an infusion tube were advanced as far as possible (caecum) and clipped to the mucosa. Colonic pressures were recorded for three hours before and two after a standardised meal, and for one hour after intra-colonic bisacodyl (10 mg). Abdominal discomfort, abdominal gas, desire to evacuate gas, desire to defecate and urgency to defecate were evaluated by means of 100 mm visual analogue scale (VAS) every 15 minutes. Number of pan-colonic pressurizations (PCPs, Corsetti 2015) and of low-amplitude (LAPSs, Dinning 2014) and high-amplitude propagating sequences (HAPSs, De Schryver 2002) were evaluated. A normal response to bisacodyl was identified by the occurrence of at least one HAPS. Data (mean±SD) were compared with those obtained in 10 healthy subjects (HS) (30±11 years, 5 females). <h3>Results</h3> A total of 24 refractory slow-transit constipation patients (43±13 years, 22 females) were studied; 15 of these also referred pain or discomfort. As compared to HS, the total number of PCPs and of LAPSs was significantly lower in patients without pain (respectively, 19±21 vs 89±40 and 6±10 vs 52±39, all p &lt; 0.01), while it did not differ in patients with pain (respectively, 60±41 and 38±46). PCPs significantly increased after a meal in HS and in patients with (p &lt; 0.01) but not in those without pain (p = 0.20). Retrograde LAPSs increased significantly after the meal in HS (p = 0.01) but not in patients, regardless of the presence of pain (all p &gt; 0.25). The response to bisacodyl was normal in all patients with pain and in 2/8 (25%) of those without pain (p = 0.01). VAS scores for discomfort differed significantly between patients with pain as compared to both patients without pain and healthy subjects (P = 0.006). <h3>Conclusion</h3> Compared to slow transit patients without pain, patients with pain have a partially preserved response to meal (increased PCPs but not LAPSs), a higher prevalence of a normal response to bisacodyl and report higher score for discomfort during manometry. <h3>Disclosure of Interest</h3> None Declared
Comprehensive Analyses of Genetic Features Identify Coordinate Signatures in Diffuse Large B-Cell Lymphoma
Authors: Bjoern Chapuy, Andrew J Dunford, Chip Stewart, Atanas Kamburov, Jaegil Kim, Margaretha GM Roemer, Marita Ziepert, Amy Jiayue Li, Mike Lawrence, Julian Hess, Mara Rosenburg, Amaro N Taylor-Weiner, Robert A Redd, Heike Horn, Anne Novak, James R Cerhan, Thomas M Haberman, Andrew L Feldman, Brian K Link, Todd R Golub, Donna S Neuberg, German Ott, Reiner Siebert, Andreas Rosenwald, Gerald G Wulf, Stefano Monti, Scott J Rodig, Markus Löffler, Michael Pfreundschuh, Lorenz Trümper, Gad Getz, Margaret A. Shipp
Journal: Blood (2015)
AB1093-HPR Investigation of Hand Functions in Patients with Systemic Lupus Erythematosus
Authors: S. Baglan Yentur, Z. Tuna, A. Gokkurt, O. Mete, G. Tore, A. Tufan, D. Oskay
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic Lupus Erythematosus (SLE) is an autoimmune, chronic disease that may start with the involvements of small joints like hand and fingers in many patients. Hand problems can vary considerably from mild arthralgia to severe deformed hands. The most common problems are pain, stiffness, weakness, numbness and difficulty in daily living activities clinically. Inhibition in hand functions effects daily living activities and increases disability level. <h3>Objectives</h3> To investigate hand functions and disability level in women with SLE. <h3>Methods</h3> 27 women with SLE, 27 women with Rheumatoid Arthritis (RA) and 26 healthy controls were included in this study. Grip and pinch strength was assessed with dynamometer, dexterity was assessed with nine hole peg test (NHPT) and disability level was assessed with Turkish version of Disability Arm Shoulder and Hand Questionnaire (DASH). Differences between these measurements were analyzed. <h3>Results</h3> There were significant differences between patients with SLE and healthy controls (p&lt;0,05) and also between patients with RA and healthy controls for all measurements. However, there were significant differences only in gross strength for both hands between patients with SLE and RA (p&lt;0,05). <h3>Conclusions</h3> Hand functions and disability level were significantly different between patients with SLE and healthy controls although these measurements were generally similar between patients with SLE and RA. Hand involvement, disability and disfunction are known for patients with RA in literature. According to our results, hand disfunctions of patients with SLE are as prominent as patients with RA. So, in the treatment of SLE, hand functions should not be ignored and should be included in rehabilitation programme. <h3>References</h3> Johnsson, P. M., Sandqvist, G., Bengtsson, A., &amp; Nived, O. (2008). Hand function and performance of daily activities in systemic lupus erythematosus.Arthritis Care &amp; Research, 59(10), 1432–1438. Bleifeld C. J., &amp; Inglis A. E. (1974). The hand in systemic lupus erythematosus. The Journal of Bone &amp; Joint Surgery, 56(6), 1207–1215. <h3>Disclosure of Interest</h3> None declared
PWE-151 Alcohol-Related Admissions to A Central London Hospital: Too Little Coding; Too Much Resource: Abstract PWE-151 Table 1
Authors: W Blad, J Lovendoski, P Morris, J Varley, M Foxton
Journal: Gut (2016)

<h3>Introduction</h3> Alcohol-related harm costs the NHS £3.6 billion per year, of which 78% is costs to the hospital.<sup>1</sup> Alcohol is traditionally poorly coded in UK hospitals and so estimating alcohol-related admissions and the resources they consume can be challenging. Underestimation may adversely influence service requirements and underestimate the impact of cost reduction measures. <h3>Methods</h3> Hospital admissions to a Central London Hospital for a 101 day period were identified from four sources: A search of 25 alcohol-related ICD-10 discharge diagnosis codes; Patients reviewed by the alcohol liaison nurse; All CT Head scans completed were analysed for evidence of alcohol misuse; Patients attending The Accident and Emergency Department (A&amp;E) with alcohol misuse. <h3>Results</h3> Over this 101 day period, 537 admissions in 349 individual patients with harmful/hazardous alcohol use were identified with a total of 2,855 inpatient bed days and 104 day case procedures. 237 (44%) of these admissions did not have an alcohol-related discharge code. The mean admission length was 5.3 days. Fifty-eight percent of these patients had presented to the hospital at least once in the previous year with a total of 914 attendances, resulting in 518 admissions. This estimates 1,941 admissions per year in patients who drink to excess and a total of 10,318 inpatient bed days, equating to 28 inpatients per day. Eighty percent of these were emergencies accounting for 9.5% of all emergency admissions to the hospital. The table lists the resources used by this cohort both during the index admission and over the past 12 months: Over the same period, A&amp;E ordered 464 CT Head scans, of which 112 (24%) were due to alcohol with head injuries being the commonest indication (34.4% alcohol-related). Alcohol was involved in 133 (22.2%) scans done within 24 hours of admission, estimating almost 500 scans per year. <h3>Conclusion</h3> Our data demonstrates that alcohol admissions are poorly coded and therefore the extent of alcohol-related resource use is likely to be an underestimation. We expect there to be further admissions not picked up using the above methods. Alcohol-related admissions account for high resource use and the costs, in bed days alone, exceed £3,500,000 per year in a single hospital. Accurately coding admissions is crucial to ensure that this group of patients, with high resource use, can be identified so that measures can be taken to treat their alcohol misuse and reduce the burden on healthcare. <h3>Reference</h3> 1 Statistics on Alcohol: England, 2013. Health and Social Care Information Centre. 2013. <h3>Disclosure of Interest</h3> None Declared
SAT0373 Efficacy and Safety of Golimumab in Patients with Active, Very Early Peripheral Spondyloarthritis: First Results from The Crespa Study, A Monocentric, Placebo-Controlled Randomized Trial: Table 1
Authors: P. Carron, G. Varkas, H. Cypers, L. Van Praet, D. Elewaut, F. Van den Bosch
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Objectives</h3> To evaluate the efficacy and safety of golimumab in patients with active peripheral Spondyloarthritis (pSpA) in a very early stage of the disease. <h3>Methods</h3> CRESPA (Clinical REmission in peripheral SPondyloArthritis) is an ongoing monocentric study of golimumab treatment in pSpA patients. Eligible patients were ≥18 years and fulfilled the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for pSpA. All patients had a symptom duration of less than 3 months. Patients were randomized 2:1 to receive golimumab 50 mg every 4 weeks or matching placebo for 24 weeks. The primary endpoint was the percentage of patients achieving clinical remission at week 24. Clinical remission was defined as the absence of arthritis, enthesitis and dactylitis on clinical examination. From week 12 onwards, there was an option to start rescue medication with golimumab 50 mg SC every 4 weeks. Adverse events were recorded throughout the study. <h3>Results</h3> In total 60 patients were randomized of whom 20 to the placebo group and 40 to the golimumab group. Baseline demographics and disease characteristics were generally similar between the 2 groups. At week 24 a significant higher percentage of patients receiving golimumab achieved clinical remission compared to patients receiving placebo (75% (30/40) versus 20% (4/20); P&lt;0.001). At week 12 similar results were observed (70% (28/40) versus 15% (3/20); P&lt;0.001). Overall, improvement in other outcomes was significantly greater in the golimumab group compared to the placebo group (table 1). In the placebo group 10 out of 20 patients (50%) entered the rescue arm, compared to only 4 of 40 (10%) patients in the golimumab arm. The rates of adverse events were very low and similar in both treatment groups. <h3>Conclusions</h3> In patients with active, very early peripheral spondyloarthritis, treatment with golimumab led to high percentages of clinical remission and significant improvement in all secondary efficacy outcomes, compared to placebo, with a safety profile consistent with that observed in anti-TNF trials with ankylosing spondylitis and psoriatic arthritis patients. <h3>Disclosure of Interest</h3> None declared
Oxidative Stress-Mediated Activation of AKT/mTOR Signaling Pathway Leads to Myeloproliferative Syndrome in FoxO3 Null Mice: A Role for Lnk Adaptor Protein
Authors: Safak Yalcin, Sathish Kumar Mungamuri, Dragan Marinkovic, Xin Zhang, Wei Tong, Dana Cullen, Saghi Ghaffari
Journal: Blood (2008)
Growth Arrest-Specific Gene 6 (Gas6) Deficiency in Mice Alleviates Graft-versus-Host Disease (GVHD) in the Liver.
Authors: Laurent Burnier, Jean-Marc Herbert, Pierre Savi, Désiré Collen, Edward M. Conway, Peter Carmeliet, Shozo Izui, Anne Angelillo-Scherrer
Journal: Blood (2004)
Aberrant NK Receptor Signaling Associated with Large Granular Lymphoycte Leukemia and Primary Pulmonary Hypertension.
Authors: P.K. Epling-Burnette, Xianhong Chen, Junmin Zhou, Fanqi Bai, Sokol Lubomir, Edna Ku, Jeffrey S. Painter, Zou JianXiang, Todd D. Edwards, Djeu Y. Julie, Moscinski C. Lynn, Thomas P. Loughran, Sheng Wei
Journal: Blood (2007)