tbuckley/cabot-search huggingface dataset:
SAT0421 Association between Diabetes Mellitus and Osteoarthritis: A Systematic Literature Review and Meta-Analysis
Authors: K. Louati, F. Berenbaum, J. Sellam
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Beyond the obesity-related osteoarthritis (OA), metabolic syndrome (MetS) related-OA has now been characterized as a subtype of OA due to the association between OA and MetS or its components. Some studies have suggested an association between OA and diabetes mellitus (DM). <h3>Objectives</h3> Based on a systematic literature review (SLR), we aimed to investigate the prevalence of DM in OA patients, the prevalence of OA in DM patients and whether OA and DM are associated. <h3>Methods</h3> A SLR was performed using 3 electronic databases (PubMed, Embase and Cochrane) in June 2013, updated in January 2014 and abstracts of international meetings (OARSI, EULAR and ACR 2011-13). We included cohort, case-control and cross-sectional studies assessing the number of patients with DM and/or OA. The prevalence of DM in OA patients and the prevalence of OA in diabetic patients were calculated. The results from trials assessing an association between diabetes and OA were pooled by meta-analysis using the RevMan-5 software and results were presented as unadjusted odds ratio (OR) and 95% confidence interval [95%CI]. In a sensitivity analysis, we removed studies with aberrant results and a random effect was performed in case of high heterogeneity between studies. <h3>Results</h3> From the 292 published studies, 42 were included in the analysis: 21 cross-sectional, 11 cohort and 10 case-control studies. Sixteen, 5 and 21 involved exclusively OA patients, exclusively diabetes and general population, respectively. The median of STROBE quality scale was 69%. Among the 32 studies assessing the association between OA and DM, 20 displayed a significant association. In 618,066 patients with OA (hand, knee, hip or other localisation), DM prevalence was 14.4±0.1% (mean ± SD). In 5,489 patients with DM, OA prevalence was 27.8±1.2% There was an increased risk of DM in OA population (OR =1.43 [1.21-1.68]) as well as of OA in DM population (OR=1.46 [1.06-2.02]) (Figure), despite heterogeneity between studies. Among the 12 studies which reported OR adjusted at least on BMI, 6 showed no association between DM and OA (smaller OR =0.56 [0.14-2.24]) while 6 identified DM as an independent risk factor of OA (higher OR =5.76 [1.06-31.21]). <h3>Conclusions</h3> This SLR highlights a high frequency of OA in patients with DM and an association between both diseases. Limitations were the heterogeneity of studies due to OA and DM definitions and the inability to adjust to other OA risk factor like BMI. This study represents a further step toward the individualization of DM-related OA phenotype. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2509
TCT-793 A prospective observational analysis of patients treated with percutaneous mitral valve repair, using the MitraClip system in Switzerland - Insights from the MitraSwiss registry
Authors: Daniel Suerder, Giovanni Pedrazzini, Paul Erne, Barbara Naegeli, Stefan Toggweiler, Raban Jeger, Lutz Buellesfeld, Oliver Gaemperli, Jürg Grünenfelder, Tiziano Moccetti, Roberto Corti
Journal: Journal of the American College of Cardiology (2014)
Les variations de détection des polypes observées entre les endoscopistes dépendent du siège et du type histologique des polypes
Authors: JF Bretagne, S Hamonic, C Piette, S Manfredi, G Mallard, JF Viel, F Riou
Journal: Endoscopy (2013)

La coloscopie protège moins du cancer du côlon proximal (en amont de l'angle gauche) que du cancer du côlon distal. Cela pourrait être la conséquence de polypes plus souvent manqués à droite qu'à gauche. Le but de ce travail a été d'étudier les variations de détection des polypes au sein d'une population d'endoscopistes en fonction du siège des polypes et du type histologique des polypes.
Sustained Remissions after Chemotherapy for Primary Ovarian Cancers Containing Choriocarcinoma
Authors: Jerry A. Wider, John R. Marshall, C. Wayne Bardin, Mortimer B. Lipsett, Griff T. Ross
Journal: New England Journal of Medicine (1969)

Three of four patients with persistent, primary ovarian carcinoma containing choriocarcinoma treated with combined methotrexate, actinomycin D and chlorambucil have sustained remissions lasting for 14 months to four and a half years. To our knowledge these are the first such patients reported to have survived for more than 12 months after diagnosis. These results support the use of vigorous chemotherapy for patients with primary ovarian cancers containing choriocarcinoma when attempted surgical cure has failed.
Radiotherapist Glatstein Honored By Colleagues
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Radiotherapist Glatstein Honored By Colleagues Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 3, 5 February 1992, Page 145, https://doi.org/10.1093/jnci/84.3.145 Published: 05 February 1992
Atlas Maps Cancer Mortality Among Nonwhites
Authors: M. E. Newman
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Atlas Maps Cancer Mortality Among Nonwhites Get access Michael E. Newman Michael E. Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 2, 16 January 1991, Page 89, https://doi.org/10.1093/jnci/83.2.89 Published: 16 January 1991
The study of orthographic processing has broadened research in visual word recognition
Authors: Carol Whitney
Journal: Behavioral and Brain Sciences (2012)

Abstract Interest in orthographic processing reflects an expansion, not constriction, of the scope of research in visual word recognition (VWR). Transposition effects are merely one aspect of investigations into orthographic encoding, while open bigrams can accommodate differences across languages. The target article's inaccurate characterization of the study of orthographic processing is not conducive to the advancement of VWR research.
Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia
Authors: Kanti R. Rai, Bercedis L. Peterson, Frederick R. Appelbaum, Jonathan Kolitz, Laurence Elias, Lois Shepherd, John Hines, Gregory A. Threatte, Richard A. Larson, Bruce D. Cheson, Charles A. Schiffer
Journal: New England Journal of Medicine (2000)

Fludarabine is an effective treatment for chronic lymphocytic leukemia that does not respond to initial treatment with chlorambucil. We compared the efficacy of fludarabine with that of chlorambucil in the primary treatment of chronic lymphocytic leukemia.
Suppression of motion during saccades
Authors: David C. Burr
Journal: Behavioral and Brain Sciences (1996)

Saccadic eye movements create (at least) two related but distinct problems for the visual system: they cause rapid image motion and a displacement of the retinal image. Although it is often assumed that the motion is too fast to be resolved, this is certainly not the case for low-spatial-frequency images. Recent experiments have suggested that the reason we are unaware of the motion during saccades is because motion channels are selectively suppressed, possibly by suppression of the magno-cellular (but not the parvocellular) pathway. This suppression may explain why there is no sensation of motion during saccades, but it leaves open the problem of perceiving a stable world despite continual image displacements.
PROSTHESIS PATIENT MISMATCH IN TRANSCATHETER AORTIC VALVE REPLACEMENT IS RELATED TO BODY SIZE INDEXED ANNULAR DIMENSION
Authors: Andrew R. Weintraub, Valeria Milazzo, Hassan Rastegar, Carey Kimmelstiel, Duc Pham, Ayan Patel, Vilma Castaneda, Eleonora Avenatti, Natesa Pandian
Journal: Journal of the American College of Cardiology (2016)
Hemorrhagic bullous colitis in a patient with multiple myeloma
Authors: S. Cho, S. Kim, W. Kim, L. Chul-Hyun, B. Go
Journal: Endoscopy (2013)

A 65-year-old woman diagnosed with multiple myeloma 5 months previously (monoclonal immunoglobulin [Ig]G kappa 26.9 g/L, dystrophic plasma cells, and bone marrow infiltration) who was being treated with melphalan and prednisolone reported hematochezia and hypogastric pain of 5 hours duration. She had undergone upper and lower gastrointestinal endoscopic examinations 2 years previously with no abnormal findings reported.
SAT0169 Frequency of Spondyloarthritis in Italian Patients with BehÇEt’S Disease
Authors: P. Leccese, S. D’Angelo, M. Gilio, A. nigro, M. Lofrano, C. Palazzi, A. Padula, I. Olivieri
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Till now the debate on the relationship between Behçet's disease (BD) and spondyloarthritis (SpA) has been limited to whether the frequency of sacroiliitis and ankylosing spondylitis (AS) is greater or not in patients with BD than in controls. But if BD and SpA occur together more frequently than by change, it should be possible to find patients with BD showing different forms of SpA. In actual fact, some patients with BD and undifferentiated SpA were reported in the last two decades. Recently, the Assessment of SpondyloArthritis international Society (ASAS) developed and validated classification criteria for axial and peripheral SpA that are going to substitute the Amor criteria and the European Spondylarthropathy Study Group (ESSG) criteria for all forms of SpA. <h3>Objectives</h3> The aim of our study was to evaluate the frequency of Italian patients with BD meeting the ASAS classification criteria for SpA. <h3>Methods</h3> Consecutive patients attending the outpatient clinic for BD of the Rheumatology Department of Lucania and meeting the International Study Group (ISG) criteria were assessed. Each patient was asked about the presence of SpA or related diseases, such as psoriasis and inflammatory bowel disease (IBD), in his first-degree relatives. Each patient was evaluated for clinical manifestations of SpA including, inflammatory low back pain, spinal limitation and deformity, peripheral arthritis, peripheral enthesitis, dactylitis and acute anterior uveitis. Pelvic plain films were obtained in all patients and examined blindly and independently for sacroiliac joint changes by two observers. HLA typing was performed by PCR-SSP. <h3>Results</h3> During a 6-month period, 74 consecutive patients (49 M, 25 F; mean age 39.8±11.4 yrs; mean disease duration 17.8±8.9 yrs; 64% HLA-B51 positive) with BD were recruited. Seven (9.4%) out of them met the ASAS classification criteria for SpA. Of these, 1 had axial disease with the feature of AS and 6 peripheral SpA. In 2 of these 6, acute anterior uveitis without posterior involvement was essential for the diagnosis of SpA. The remaining 4 had psosiasis, dactylitis, enthesitis or inflammatory chronic low back pain in addition to peripheral arthritis. Two of the 7 patients with SpA features were HLA-B27 positive. <h3>Conclusions</h3> Italian patients with BD show a higher frequency of SpA, as defined by the ASAS criteria, than that expected in the general population. <h3>Disclosure of Interest</h3> None Declared
Abstract 2217: Analysis of mitochondrial variations in non-small cell lung cancer (NSCLC) by microarray-based genome resequencing
Authors: Zhaoxi Wang, Sojung Choi, Yen-Tsung Huang, Feng Chen, Xihong Lin, Donna Neuberg, Jhin Kim, David C. Christiani
Journal: Cancer Research (2010)

Abstract The human mitochondrial genome is a circular double-stranded DNA molecule (mtDNA) of 16,569 base pairs, encoding 13 proteins that are essential in oxidative phosphorylation, two ribosomal genes, and 22 tRNAs. The mtDNA genome has a high copy number per cell, replicates independently of the nuclear genome, and has a maternal-inherited pattern. Mutations in mtDNA genome have long been suspected to play an important role in the development of cancer. Although most cancer cells harbor mtDNA mutations, the question of whether such mutations are associated with clinical prognosis of cancer remains unclear. In this study, we resequenced the entire mitochondrial genomes of tumor tissue from a population of 249 Korean non-small cell lung cancer (NSCLC) patients using the Affymetrix GeneChips Human Mitochondrial Resequencing Array 2.0 (Santa Clara, CA). A total of 892 single nucleotide polymorphisms (SNPs) were identified, including 269 (30.2%) synonymous SNPs, 142 (15.9%) non-synonymous SNPs, 78 (8.7%) SNPs in non-coding region, 188 SNPs (21.1%) in control region, as well as 215 (24.1%) previously unreported SNPs. Each tumor sample contained at least 6 mitochondrial SNPs, with maximum 41 SNPs. We selected 189 (21.2%) SNPs with frequency &amp;gt;2.5% for subsequent analyses. Single SNP analysis using Cox proportional hazards models identified 19 SNPs with p value &amp;lt; 0.05, but none of them remained significant after adjustment for multiple comparisons. Unsupervised clustering analysis revealed two major SNP signature panels, including Signature Panel 1 (8 SNPs) and Signature Panel 2 (5 SNPs). Accordingly, the patient population was divided into three groups: 68 (27.3%) subjects with both signature panels, 73 (29.3%) subjects with only the Signature Panel 1 but not the Signature Panel 2, and 108 (43.4%) subjects without signature panel. In early stage (stage I/ II) NSCLC, patients with the Signature Panel 2 had the worst clinical prognosis, and patients without any signature panel performed best in the survival analyses (adjust hazard ratio=1.83; 95% confidence interval, 1.25-2.66; p=0.003). Further mitochondrial haplogroup analysis identified that the Signature Panel 1 had most defining mutations for haplogroup M and N, and the Signature Panel 2 contained all defining mutations of haplogroup D4a. Interestingly, haplogroup D4a was previous reported as a marker for extreme longevity in Japanese. We conclude that mtDNA mutations may play an important role in survival among early stage lung cancer patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2217.
AB0690 Uveitis in the course of juvenile idiopathic arthritis (jia)
Authors: L. Rutkowska-Sak, R. Stawowski
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Uveitis is a frequent symptom of JIA. <h3>Objectives</h3> The aim of this study was to analyze the clinical course of JIA with uveitis in 106 children (66 girls and 40 boys) hospitalized in the Department of Developmental Age Rheumatology of the Institute of Rheumatology in Warsaw in the years 1964-2009 and to compare the course of the disease before and after 1990. <h3>Methods</h3> Each patient underwent eye examination, pediatric rheumatologist observation and laboratory tests (ESR, platelets, CRP, IL-1, ANA). <h3>Results</h3> The most common form of the disease (JIA with uveitis) is oligoarthritis (80,1%) and the most common first symptom of the disease is arthritis (58,4% of patients). Girls get sick more often, however boys are hospitalized much more often. Most cases of uveitis in the course of JIA occur in the early years of childhood. Uveitis is the first symptom of the disease in 13,2% of patients and more often in boys. Simultaneous occurrence of articular and eye symptoms (26,4% of patients) is more characteristic in girls. In the group of children with oligoarthritis onset of JIA, monocular uveitis is more frequent and independent of sex. In groups with polyarthritis and systemic onset of JIA, dominates occurrance of uveitis in both eyes and more often in boys (not statistically significant – NS). Most common symptom of uveitis is an inflammation of the anterior segment of the eye of a moderate degree and is more common in girls. Inflammation of the anterior segment of the eye of a large and intensive degree is less common and is more characteristic in boys (NS). Elevated ESR, platelets, CRP levels are more common in boys with uveitis (p&lt;0,05). Elevated IL-1 levels are observed more frequently in patients with uveitis than in children without it (p&lt;0,05). In children with JIA hospitalized before 1990 intensive degree of the disease was observed more often. In children hospitalized after 1990 cataract, which is the complication of the disease, is observed more often. The atrophy of the eye is also possible. <h3>Conclusions</h3> Despite of the intensification of the basic treatment of JIA and better treatment results in the joints, uveitis in the course of JIA is still a very serious diagnostic and therapeutic problem. <h3>References</h3> Anesi SD, Foster CS Importance of recognizing and preventing blindness from juvenile idiopathic arthritis-associated uveitis. Arthritis Care Res. 2012; 64: 653-657 Zak M, Fledelius H, Pedersen FK Ocular complications and visual outcome in juvenile chronic arthritis: a 25-year follow-up study. Acta Ophthalmol Scand 2003; 81: 211-5 Petty RE, Smith JR Rosenbaum JT. Arthritis and uveitis in children: a pediatric rheumatology perspective. Am J Ophthalmol 2003; 135: 879-84. <h3>Disclosure of Interest</h3> None Declared
Hot Scrotum Caused by Teratoma of the Testis
Authors: KEVIN KL CHOONG
Journal: Clinical Nuclear Medicine (1996)

Testicular teratoma is a relatively rare germ-cell neoplasm that behaves as a malignant tumor in adults and as a benign tumor in prepubertal children. Teratomas are classified as mature, immature, or with malignant transformation (World Health Organization classification). Mature teratomas are composed of a mixture of differentiated mesoderm (cartilage and bone are derived from mesoderm), ectoderm, and endoderm. The Tc-99m MDP bone scan appearances of a patient with a mature testicular teratoma containing multiple foci of cartilage and bone is presented.
A Randomized Trial of Unsedated Transnasal Small-Caliber Esophagogastroduodenoscopy (EGD) versus Peroral Small-Caliber EGD versus Conventional EGD
Authors: C Preiss, J P Charton, B Schumacher, H Neuhaus
Journal: Endoscopy (2003)

Background and Study Aims: Unsedated esophagogastroduodenoscopy (EGD) has advantages over sedated EGD - e. g., prevention of side effects related to sedation, less patient monitoring, and less expense. This study compared the feasibility and tolerance of transnasal small-caliber (TSC-EGD) and peroral small-caliber EGD (PSC-EGD) with conventional EGD (C-EGD). Patients and Methods: A total of 150 patients referred for diagnostic EGD were randomly allocated to undergo either TSC-EGD, PSC-EGD, or C-EGD under local anesthesia if they agreed to receive sedation only on demand or in case of intolerance. Patients, endoscopists, and nurses completed questionnaires on the tolerability and quality of the examinations using a visual analogue scale (VAS), ranging from 1 (best/nonexistent) to 10 (worst/unbearable) after EGD. Small-caliber EGD and C-EGD were performed with 5.9-mm and 9.8-mm video endoscopes (Olympus), respectively.
Local steroid injection into the artificial ulcer created by endoscopic submucosal dissection for gastric cancer: prevention of gastric deformity
Authors: H. Mori, K. Rafiq, H. Kobara, S. Fujihara, N. Nishiyama, M. Kobayashi, T. Himoto, R. Haba, M. Hagiike, K. Izuishi, K. Okano, Y. Suzuki, T. Masaki
Journal: Endoscopy (2012)

<b>Background and study aims:</b> Endoscopic submucosal dissection (ESD) of large gastric lesions results in an extensive artificial ulcer that can lead to marked gastric deformity. The aim of the current study was to evaluate therapeutic efficacy in the prevention of gastric deformity of local triamcinolone acetonide (TCA) injection into the extensive artificial ulcer following ESD. <b>Patients and methods:</b> A total of 45 patients who were diagnosed with early gastric cancer were enrolled. Patients were randomly assigned by the sealed-envelope randomization method to either local TCA injections (n = 21) or sham-control (n = 20) groups. Two clips were placed at the two maximum outer edges of the artificial ulcer after the lesion had been resected (Day 0). Local TCA injections were performed on postoperative Day 5 and Day 12. The distance between the two clips was measured by endoscopic measuring forceps on Days 5, 12, 30, and 60. Granulation formation and gastric deformity were evaluated by visual analog scale (VAS) on Days 30 and 60. <b>Results:</b> Local TCA injection did not alter clip-to-clip distance on postoperative Day 60, and formation of flat granulation tissue over the ulcer was followed by regenerative mucosa without any gastric deformity. The sham-control group showed significant shortening of clip-to-clip distance compared with the local steroid-injected group and protruded forms of granulation tissue with mucosal convergence. Histological evaluation revealed prominent growth of neovessels, swelling, and marked increases in endothelial cells in the local steroid-injected group compared with the sham-control group. <b>Conclusions:</b> Local steroid injection into the floor of a post-ESD artificial ulcer promotes the formation of granulation tissue at an early stage of the healing process leading to regeneration of gastric mucosa without mucosal convergence or gastric deformity.
Abstract 2091: MiR-145 functions as a potential tumor suppressor in hepatocellular carcinoma
Authors: Priscilla TY LAW, Arthur KK Ching, Queenie WL Wong, Paul BS Lai, Nathalie Wong
Journal: Cancer Research (2010)

Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths worldwide. The pathogenesis of HCC has been associated with various genetic and epigenetic alterations, including microRNA dysregulation. In defining the differentially expressed miRNAs in HCC, we previously reported on HCC-specific microRNA deregulations by array-based profiling, which revealed common down-regulations of miR-145. Subsequent verification of miR-145 expression in an independent cohort of 72 HCC cases by qRT-PCR corroborated significant down-regulations in tumors compared to their non-malignant counterparts (49%; paired t-test p=0.026). Transfection of miR-145 into HCC cell lines, HKCI-C2 and HKCI-9, showed a consistent inhibitory effect on both cell viability and proliferation as indicated by MTT and colony formation assays. Flow cytometric analysis on HKCI-C2 further indicated that miR-145 could induce G2/M cell cycle arrest and increase apoptosis. MiR-145 has been shown to target insulin receptor substrate 1 (IRS1) in colorectal cancer. It is known that IRS1 is a substrate of insulin-like growth factor receptor (IGF-1R) in the IGF signaling pathway. In-silico prediction by Targetscan, miRNAda and RNAhybrid suggested that miR-145 might also target IGF-1R and IRS2 along the IGF axis. The effects of miR-145 on these IGF components were hence investigated. Our results from Western blot indicated that IRS1 expression was down-regulated in the presence of miR-145, suggesting that it might also be a target of miR-145 in HCC. Taken together, we found that miR-145 could induce cell cycle arrest and apoptosis in HCC cells, possibly through its effect on IRS1. This study reveals for the first time that miR-145 may act as a tumor suppressor in the liver tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2091.