tbuckley/cabot-search huggingface dataset:
Effectiveness and safety of second-line (2L) irinotecan- and oxaliplatin-based regimens after first-line (1L) bevacizumab (BV)-containing treatment (tx) for metastatic colorectal cancer (mCRC): Results from the ARIES observational cohort study.
Authors: Tanios S. Bekaii-Saab, Axel Grothey, Johanna C. Bendell, Mark Kozloff, Allen Lee Cohn, Yong Mun, Susan Fish, Elizabeth Dawn Flick, Darshan Dalal, Herbert Hurwitz
Journal: Journal of Clinical Oncology (2012)

535 Background: Prior ARIES analyses showed that BV-treated mCRC patients (pts) receiving chemotherapy (CT)/biologics + BV within 2 months (mo) after 1 st progressive disease (PD) had longer post-progression survival (PPS) than pts receiving only CT/biologics. The present analysis evaluated whether this effect of BV was consistent when used with common 2L CT regimens— irinotecan- (iri-) and oxaliplatin- (ox-) based—in mCRC pts exposed to 1L BV in ARIES. Methods: ARIES enrolled mCRC pts receiving 1L CT + BV. No tx regimens or assessments were protocol specified. This analysis evaluated 1L BV-treated mCRC pts who had PD, survived ≥2 mo after PD, and received 2L iri- or ox-based tx. PPS was estimated by Kaplan-Meier methods. Cox regression was used to estimate hazard ratios (HRs), while adjusting for covariates (eg, 1L time to progression). Results: Of 1550 1L pts in ARIES, 1074 had 1 st PD and survived ≥2 mo after PD. Of these 1074, 390 and 114 received 2L iri- and ox-based tx, respectively, ± BV ( table ). Baseline characteristics were generally similar between groups. The incidence of targeted adverse events (TAEs) was as expected and similar between the BV and No BV groups over time. In pts receiving 2L iri- or ox-based CT tx, PPS in BV-treated pts was longer compared to those not on BV. Analyses may be limited by small pt numbers in some groups. Conclusions: Consistent with prior ARIES analyses, the continued use of BV after 1 st PD was associated with prolonged PPS regardless of the 2L CT backbone used. [Table: see text]
Abstract 3954: lincRNA-UFC1 facilitates cell proliferation and tumor growth in hepatocellular carcinoma by upregulating HuR/β-catenin expression
Authors: LI LIU, Dehua Wu, Chuanhui Cao
Journal: Cancer Research (2015)

Abstract BACKGROUND &amp; AIMS: Long noncoding RNAs (lncRNAs) have been identified as novel regulators of biologic behaviors in various cancers. However, the oncogenic mechanisms of lincRNA-UFC1 associated with hepatocellular carcinoma (HCC) growth and progression are still unknown. Here, we delved into the mechanistic aspects of lincRNA-UFC1in HCC progression. METHODS: LncRNA expression profiles are assessed by microarray analysis. Expression of lincRNA-UFC1 was examined in 2 HCC cohorts (cohort 1, n = 49; cohort 2, n = 131) by quantitative real-time PCR or by in situ hybridization. The functions of lincRNA-UFC1 in HCC cells were elucidated by in vitro and in vivo gain- and loss-of-function experiments. The mechanism by which lincRNA-UFC1 contributes to HCC progression was explored through luciferase reporter assays, RNA immunoprecipitation and RNA pull-down assays. RESULTS: LincRNA-UFC1 was strongly upregulated in HCC tissues, compared with corresponding non-tumor tissues in patients from 2 cohorts. LincRNA-UFC1 expression is associated with tumor size, Barcelona Clinic Liver Cancer (BCLC) stage and poor prognosis. Enhanced lincRNA-UFC1 expression promotes cell proliferation and tumor growth, inhibits apoptosis, and induces cell cycle progression, whereas decreased lincRNA-UFC1 expression represented the opposite effects. Furthermore, lincRNA-UFC1 directly interacts with HuR and regulates β-catenin expression. The level of lincRNA-UFC1 is positively correlated with that of β-catenin in HCC tissues. CONCLUSIONS: These findings indicate that lincRNA-UFC1 promotes HCC development and progression, indicating its role as a potential therapeutic target for HCC. Citation Format: LI LIU, Dehua Wu, Chuanhui Cao. lincRNA-UFC1 facilitates cell proliferation and tumor growth in hepatocellular carcinoma by upregulating HuR/β-catenin expression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3954. doi:10.1158/1538-7445.AM2015-3954
Lucabis: a Burden-Of-Illness Study in Patients with Stage Ib-Iiia Non-Small Cell Lung Cancer in France, Germany and the Uk
Authors: S. Danson, S. Andreas, C. Chouaid, O. Siakpere, L. Benjamin, R. Ehness, M. Dramard-Goasdoue, J. Barth, M. Price, S. Wolowacz, J.A. Kaye, I. Kontoudis
Journal: Annals of Oncology (2014)
Sleepwalking and recurrent sleeptalking in children of childhood sleepwalkers
Authors: K Abe, M Amatomi, N Oda
Journal: American Journal of Psychiatry (1984)

Thirty-seven children, one or both of whose parents had sleepwalked during childhood, were studied prospectively. At 8 years of age, they were more likely to manifest sleepwalking, recurrent sleeptalking , and emotional lability than control children.
Low-Dose Lenalidomide Plus Low Dose Cytarabine Induce Complete Remission That Can Be Predicted By Genetic Profiling In Very Elderly Acute Myeloid Leukemia Patients
Authors: Giuseppe Visani, Francesco Di Raimondo, Felicetto Ferrara, Federica Loscocco, Pier Paolo Piccaluga, Fabio Fuligni, Anna Gazzola, Maura Rossi, Antonella Laginestra, Maria Rita Caraci, Cira Riccardi, Axel Visani, Sara Barulli, Barbara Guiducci, Teresa Ricciardi, Giovanni Sparaventi, Marco Rocchi, Alessandro Isidori
Journal: Blood (2013)
The cutting edge in psychiatry
Authors: G D Strauss, J Yager, G E Strauss
Journal: American Journal of Psychiatry (1984)

The authors sampled the views of 138 "experts" in psychiatry in relation to three questions: 1) What were the major accomplishments of 1970-1980? 2) What were the important publications of the decade? 3) What important questions will be answerable in the next decade? Advances in basic sciences and in psychopharmacology led the list for the past decade. Fourteen publications were mentioned four or more times; DSM-III headed the list. The experts predicted that we can anticipate advances in understanding the causes and in the treatment of major disorders. Despite methodological constraints, these results have implications for training medical students and house staff, for continuing education, and for the allocation of research resources.
Nature, Nurture, and Family Predisposition
Authors: Roger R. Williams
Journal: New England Journal of Medicine (1988)

Both genes and a shared environment can endow members of a family with a predisposition to the same disease. Familial aggregation has been reported for most common diseases (cardiovascular, neoplastic, emotional, and endocrine, among others).1 2 3 4 Causal factors that affect a person's susceptibility or resistance to a particular disease can generally be derived either from genes (nature) or from the environment (nurture). Major effects from a single gene (monogenic trait) are observed in such disorders as familial hypercholesterolemia. The blended effects of many genes (polygenic traits) often account for approximately 50 percent or more of the variation in the normal population . . .
Management of Patients with Portal Hypertension Undergoing Venous-Shunt Surgery
Authors: W. Carl Ebeling, John P. Bunker, Daniel S. Ellis, Arthur B. French, Robert R. Linton, Chester M. Jones
Journal: New England Journal of Medicine (1956)

THE dangers of surgery in patients with liver disease have long been recognized but poorly understood. With the recent development of venous-shunt surgery for the relief of portal hypertension a relatively large group of such patients have become available for study. This report represents ten years' experience with 129 patients undergoing 140 anastomoses and attempted anastomoses between the portal and systemic venous systems. Correlation of preoperative clinical and laboratory findings with operative and immediate postoperative events has provided prognostic criteria for the selection and management of this particular group of patients — and for the management of any patient with . . .
THU0503 Anti-C1Q Antibody as Marker of Renal Involvement in Childhood-Onset Systemic Lupus Erythematosus
Authors: C. Picard, N. Fabien, B. Ranchin, P. Cochat, A. Belot
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Lupus nephritis (LN) frequently occurs in the clinical course of childhood-onset systemic lupus erythematosus (cSLE) and is involved in higher long-term morbidity and mortality of the disease compared to adults. Avoiding a progression to end-stage renal disease and, in the same time, minimizing current toxic treatment regimens is challenging in such young patients. Hence, clinicians need reliable biological markers in order to predict renal involvement. The association of anti-C1q antibodies (Abs) with lupus nephritis in adults is supported by several studies but remains uncertain in children. <h3>Objectives</h3> This single center study aimed at investigating the capacity of anti-C1q Abs to predict renal flare at diagnosis and during the follow-up of cSLE. <h3>Methods</h3> Anti-C1q Abs assays were performed retrospectively by ELISA in 17 patients from a single tertiary center, presenting with cSLE at diagnosis, at time of a renal flare-up or in a quiescent phase of the disease. Disease activity was measured with SLEDAI score which includes dsDNA aAbs. C3, C4, type I interferon were also analyzed in all patients. <h3>Results</h3> Five patients with a renal involvement at diagnosis of cSLE had positive anti-C1q aAbs at a high rate (&gt;200UI/ml) (100%). A total of 11 flares were recorded during the time of the study. Anti-C1q antibodies were positive in 8 of these flares (72,7%). The negativity of anti-C1q Abs during these flares (n=3) was presumably due for one patient to a monogenic form of cSLE associated with a homozygous <i>PRKCD</i> mutation. In the other cases, levels of anti-C1q Abs were just below the limit of positivity and became positive at the time of the next renal flare. <h3>Conclusions</h3> Anti-C1q antibodies represent a reliable marker of LN flares in children with cSLE and may be performed routinely during the follow-up of these patients. <h3>References</h3> Orbai, A.-M. et al. Anti-C1q antibodies in systemic lupus erythematosus. Lupus 24, 42–49 (2015). Yin, Y., Wu, X., Shan, G. &amp; Zhang, X. Diagnostic value of serum anti-C1q antibodies in patients with lupus nephritis: a meta-analysis. Lupus 21, 1088–1097 (2012). Gilliam, B. E., Ombrello, A. K., Burlingame, R. W., Pepmueller, P. H. &amp; Moore, T. L. Measurement of autoantibodies in pediatric-onset systemic lupus erythematosus and their relationship with disease-associated manifestations. Semin. Arthritis Rheum. 41, 840–848 (2012). Wu, F. Q., Zhao, Q., Cui, X. D. &amp; Zhang, W. C1q and anti-C1q antibody levels are correlated with disease severity in Chinese pediatric systemic lupus erythematosus. Rheumatol. Int. 31, 501–505 (2011). Edelbauer, M. et al. Markers of childhood lupus nephritis indicating disease activity. Pediatr. Nephrol. 26, 401–410 (2011). <h3>Disclosure of Interest</h3> None declared
Intralymphatic Injection of BCG Into Rhesus Monkeys
Authors: Charles E. Mangan, K. Ann Jeglum, Thomas V. Sedlacek, James E. Wheeler, John J. Mikuta
Journal: JNCI Journal of the National Cancer Institute (1975)

Since the route of administration of BCG may have an important function in immunotherapy, we investigated intralymphatic administration to direct BCG to the lymph nodes. Multiple injections of high doses of BCG were administered to 6 rhesus monkeys via the dorsal lymphatics of the lower limb. A suppurative lymphadenitis was observed along the lower limb and in the inguinal area in 5 of the 6 monkeys. However, many of the complications reported with other routes of administration were not observed. Granulomatous reactions and histiocytic responses developed in lymph nodes on the injected sides of the pelvis and distant nodes as well as in the liver. The intralymphatic route is the method by which high doses of nonspecific immunostimulants were delivered to regional lymph nodes. The efficacy of this approach remains to be established in tumor-bearing animals and humans.
Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction
Authors: Marie Evans, Juan-Jesus Carrero, Karolina Szummer, Axel Åkerblom, Robert Edfors, Jonas Spaak, Stefan H. Jacobson, Pontus Andell, Lars Lindhagen, Tomas Jernberg
Journal: Journal of the American College of Cardiology (2016)
Screening for unmet psycho-social needs in cancer care
Authors: C. Doebbeling, L. Losee, J. Powers, S. Johns, J. Connor
Journal: Journal of Clinical Oncology (2006)

8633 Background: Persons receiving cancer care are at risk for undiagnosed depression, but the burden of anxiety symptoms and social work needs is not well described. The objectives of the clinical intervention were: 1) to describe the burden of depression, anxiety and social distress; and 2) to determine whether an unmet need for psycho-social services existed in a sample of cancer patients at a university cancer center with an active psycho-social referral program. Methods: We developed a survey composed of the Memorial Distress Thermometer (MDT), specific social work needs, and the depression and anxiety modules from the Patient Health Questionnaire (PHQ). The clinical survey was administered to a convenience sample presenting for either referral visits or ongoing cancer treatment at the Indiana University Cancer Center for a four month period. Patient request for services, indicated need, and standardized threshold scores were used to determine need for referral (MDT ≥ 4; PHQ depression ≥ 10; PHQ anxiety ≥ 10). Descriptive statistics were calculated. Results: 184 patients (70% male) completed the survey. One-third of those screened met criteria for social work referral. 78% reported at least some distress (mean score 3.6) on the MDT, with 46% (n=81) scoring 4 or above. Social work needs included helping children cope with parental illness (11%), pharmaceutical expenses (11%), insurance assistance (6%), discussing illness with spouse (6%), and lodging during treatment (5%). Mental health distress was common. 34% met criteria for referral to psychological or psychiatric services. The mean PHQ depression score was 4.7, with moderate to severe depression (score ≥ 10) in 13%. Symptoms of generalized anxiety were also common, with a mean score of (5.0) and 11% scoring ≥ 10. Conclusions: In persons receiving cancer care, previously unknown distress, social work needs, depression, and anxiety were common. The burden of symptoms resulted in a markedly increased need for psycho-social services. These data reflect upon the significant need for regular screening and integration of psycho-social services with cancer treatment. No significant financial relationships to disclose.
Case 40-1997
Authors: Marc B. Garnick, Judith A. Ferry
Journal: New England Journal of Medicine (1997)

Presentation of CaseA 23-year-old man was admitted to the hospital for treatment of a mediastinal tumor.The patient had been well until five months earlier, when a nonproductive cough developed. Antibiotic treatment resulted in only slight improvement. Nine weeks before admission, he had increasing dyspnea, with night sweats. A radiograph of the chest showed an anterior mediastinal mass; he was referred to this hospital.A physical examination revealed evidence of the superior vena cava syndrome.Laboratory tests were performed (Table 1 and Table 2). Radiographs of the chest (Figure 1) showed a lobulated anterior mediastinal mass obscuring the cardiac borders, a . . .
Case 27-1981
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, George E. Thibault, Thomas H. Aretz
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 66-year-old man was admitted to the hospital because of congestive heart failure.He was well until two years earlier, when intermittent diarrhea developed. He was seen at the clinic, where examination was negative. Routine laboratory tests gave normal results. An electrocardiogram demonstrated a normal rhythm at a rate of 72, with normal PR and QRS intervals; the mean QRS axis was -60°, consistent with left anterior hemiblock. X-ray films of the chest revealed a normal appearance of the heart and lungs. A barium-enema examination disclosed lack of haustrations in the descending colon. The bowel symptoms disappeared . . .
Case 22-2004
Authors: Edward A. Nardell, Dali Fan, Jo-Anne O. Shepard, Eugene J. Mark
Journal: New England Journal of Medicine (2004)

A woman sought medical attention because of chest pain and shortness of breath. Physical examination and echocardiographic studies showed evidence of a pericardial effusion and cardiac tamponade. She was admitted to the hospital, and the effusion was drained, yielding fluid that was negative on culture and cytologic analysis. She had traveled to Kenya; a tuberculin skin test five months after the trip had been negative, but a test during hospitalization was positive.
Mortality from Breast Cancer after Irradiation during Fluoroscopic Examinations in Patients Being Treated for Tuberculosis
Authors: Anthony B. Miller, Geoffrey R. Howe, Gregory J. Sherman, Joan P. Lindsay, Martin J. Yaffe, Paul J. Dinner, Harvey A. Risch, Dale L. Preston
Journal: New England Journal of Medicine (1989)

The increasing use of mammography to screen asymptomatic women makes it important to know the risk of breast cancer associated with exposure to low levels of ionizing radiation. We examined the mortality from breast cancer in a cohort of 31,710 women who had been treated for tuberculosis at Canadian sanatoriums between 1930 and 1952. A substantial proportion (26.4 percent) had received radiation doses to the breast of 10 cGy or more from repeated fluoroscopic examinations during therapeutic pneumothoraxes. Women exposed to greater than or equal to 10 cGy of radiation had a relative risk of death from breast cancer of 1.36, as compared with those exposed to less than 10 cGy (95 percent confidence interval, 1.11 to 1.67; P = 0.001). The data were most consistent with a linear dose-response relation. The risk was greatest among women who had been exposed to radiation when they were between 10 and 14 years of age; they had a relative risk of 4.5 per gray, and an additive risk of 6.1 per 10(4) person-years per gray. With increasing age at first exposure, there was substantially less excess risk, and the radiation effect appeared to peak approximately 25 to 34 years after the first exposure. Our additive model for lifetime risk predicts that exposure to 1 cGy at the age of 40 increases the number of deaths from breast cancer by 42 per million women. We conclude that the risk of breast cancer associated with radiation decreases sharply with increasing age at exposure and that even a small benefit to women of screening mammography would outweigh any possible risk of radiation-induced breast cancer.
The amphetamine challenge test in patients with borderline disorder
Authors: S C Schulz, J Cornelius, P M Schulz, P H Soloff
Journal: American Journal of Psychiatry (1988)

The authors used amphetamine as a psychopharmacological probe to investigate the hypothesis that patients with borderline personality disorder are prone to psychosis following ingestion of a dopamine agonist. Sixteen patients with borderline personality disorder participated in the study. Significant increases in the mean total Brief Psychiatric Rating Scale scores and in activation and thought disturbance factors after amphetamine administration were noted in the sample. Patients with diagnoses of both schizotypal and borderline personality disorders worsened transiently with amphetamine administration, but patients with only the borderline diagnosis improved. These results indicate the usefulness of pharmacological probes to further understand DSM-III axis II disorders.
Muscarinic Cholinergic Receptors on Skin Fibroblasts in Familial Affective Disorder
Authors: N. Suzan Nadi, John I. Nurnberger, Elliot S. Gershon
Journal: New England Journal of Medicine (1984)

Cultured human skin fibroblasts possess muscarinic receptors with the properties of specific binding, saturability, pharmacologic specificity, inhibition of norepinephrine-stimulated adenylate cyclase, and increased binding after incubation with an antagonist. The number of binding sites appears to be a stable characteristic of each cell line. We studied fibroblasts from 18 patients with a major affective disorder and found that they had a higher density of binding sites than cells from 12 normal controls. Fibroblasts from 18 relatives who had histories of major or minor affective disorder also had a higher density, and those from five normal relatives were similar to controls. These results, although still preliminary, suggest that increased cholinergic-receptor density may be associated with vulnerability to affective disorders in some familial cases.
A Placebo-Controlled Trial of a Pertussis-Toxoid Vaccine
Authors: Birger Trollfors, John Taranger, Teresa Lagergård, Lena Lind, Valter Sundh, Gunilla Zackrisson, Charles U. Lowe, William Blackwelder, John B. Robbins
Journal: New England Journal of Medicine (1995)

Although many whole-cell vaccines have been effective in preventing pertussis, these vaccines are difficult to standardize and can produce side effects. In Sweden, pertussis became endemic during the 1970s despite vaccination. Because of its limited efficacy, the Swedish-made whole-cell vaccine was withdrawn in 1979.
Intrahepatic cholestasis of pregnancy
Authors: Sarah C Hillman, Helen Stokes-Lampard, Mark D Kilby
Journal: BMJ (2016)

#### What you need to know

A 30 year old, 35 week pregnant, nulliparous woman visits her general practitioner because of itching but no rash. Fundal height measurements and fetal movements are normal. The GP arranges an urgent antenatal clinic review, where liver function tests (LFTs), including bile acids, are reported as normal. At a midwife appointment two weeks later, she still has intense itching. Repeat tests show raised total bile acids (100 µmol/L; reference range 0-14) and aspartate aminotransferase (150 U/L; 5-35). Intrahepatic cholestasis of pregnancy is diagnosed and she is offered induction of labour that day.

Intrahepatic cholestasis of pregnancy, also called “obstetric cholestasis,” is a multifactorial condition of pregnancy characterised by pruritus in the absence of a skin …
Tremor as a Cause of Pseudo–Ventricular Tachycardia
Authors: R Llinas, G V Henderson
Journal: New England Journal of Medicine (1999)

Figure 1. An 84-year-old woman with a history of falling was found on the ground unable to get up. On admission to the hospital for evaluation of syncope, she had a normal pulse and blood pressure. Examination revealed a masklike face, bradykinesia, gait instability, and a pill-rolling tremor. An electrocardiogram showed the 4-to-6-Hz tremor associated with Parkinson's disease. The QRS complexes are indicated by the arrows. Postural instability associated with Parkinson's disease was the most likely cause of the patient's falls.
Importance of Body Characteristics in the Excretion of 17-Ketosteroids and 17-Ketogenic Steroids in Obesity
Authors: Gary Jacobson, Carl C. Seltzer, Philip K. Bondy, Jean Mayer
Journal: New England Journal of Medicine (1964)

A NUMBER of investigators have reported increased adrenocortical activity among obese persons. These reports have noted the frequency of increased urinary 17-ketogenic steroids,1 2 3 4 increased 17-hydroxycorticosteroids,5 , 6 increased aldosterone7 , 8 and cortisol secretion.9 , 10 Regarding 17-ketosteroid urinary excretion, however, divergent findings have been reported. These steroids in obese subjects have been found to be elevated,3 normal1 , 11 and even diminished.5 In addition, it has been noted in 4 cases of obese children of disparate age that dietary restriction was associated with a decline in 17-ketogenic urinary excretion from initially elevated levels.2 Although some investigators have considered the increased steroid excretion in the obese subject to . . .