tbuckley/cabot-search huggingface dataset:
AB0607 Determinants of Unemployment amongst Australian Systemic Sclerosis Patients: Table 1.
Authors: K. Morrisroe, M. Huq, W. Stevens, C. Rabusa, S. Proudman, M. Nikpour
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The ability to work is a fundamental component of everyday life. <h3>Objectives</h3> To assess employment status, risk factors for unemployment and the associations of unemployment with patients9 health related quality of life (HRQoL). <h3>Methods</h3> All patients completed in a systemic sclerosis (SSc) longitudinal cohort study, completed an employment questionnaire on enrolment. Clinical manifestations were defined based on presence at the time of enrolment. Summary statistics, chi-square tests, univariate and multivariable logistic regression were used to determine the associations of various risk factors with employment. <h3>Results</h3> Among 1587 SSc patients, 160 (20%) were unemployed at the time of cohort enrolment excluding retired patients. Of these, 63% had limited disease subtype. Mean (±SD) age at enrollment was 51.9 (±10.4) years; 13 years below the average retirement age in Australia. Mean (±SD) disease duration at recruitment was 11.1 (±10.9) years. Multivariable regression analysis revealed the presence of digital amputation (OR 3.9, 95%CI 1.7–9.1, p=0.002), diffuse disease subtype (OR 2.2, 95%CI 1.3–3.5, p-value=0.002), sicca symptoms (OR 2.7, 95%CI 1.6–4.4, p&lt;0.001), a physical job (OR 1.8, 95%CI 1.1–3.1, p=0.03) and pulmonary arterial hypertension (OR 2.2, 95%CI 1.1–4.5, p=0.02) to be associated with unemployment. Unemployed patients had consistently poorer HRQoL scores in all domains (physical, emotional and mental health) of the SF-36 form than those who were employed. <h3>Conclusions</h3> SSc is associated with substantial work disability and unemployment, which is in turn associated with poor quality of life. Raising awareness, identifying modifiable risk factors and implementing employment strategies and work place modifications are possible ways of reducing this burden. <h3>Acknowledgement</h3> This work was supported by Scleroderma Australia, Arthritis Australia, Actelion Australia, Bayer, CSL Biotherapies, GlaxoSmithKline Australia and Pfizer. Dr Morrisroe is a recipient of an NHMRC, RACP Shields Fellowship and an Australian Rheumatology Association (Vic) "top-op" PhD scholarship. Dr Nikpour holds a University of Melbourne Faculty of Medicine Dentistry and Health Science David Bickart Clinician Researcher Fellowship and is a recipient of an NHMRC Fellowship (APP1071735). <h3>Disclosure of Interest</h3> None declared
PTH-020 Too Old to Push? A Prospective Comparison Study on The Safety of Double Balloon Enteroscopy with Propofol Versus Standard Sedation in The Elderly
Authors: H-L Ching, F Branchi, DS Sanders, D Turnbull, R Sidhu
Journal: Gut (2016)

<h3>Introduction</h3> Propofol sedation is increasingly being used for complex endoscopy. Double balloon enteroscopy (DBE) has been shown to be poorly tolerated using standard sedation. We investigated the feasibility and safety of DBE in the elderly compared to the young, using propofol versus standard sedation in our routine small bowel service. <h3>Methods</h3> Between March 2013 and December 2015, all patients undergoing DBE were prospectively recruited. Standard sedation with fentanyl and midazolam or anaesthetist-assisted propofol sedation was decided based on patient history and the expected complexity of procedure. Patients were categorised by age into elderly: ≥70 years and young: &lt;70 years and the type of sedation used. Patient data from the four cohorts were collected and compared including hospital and anxiety and depression scores (HADS). Pain, discomfort and distress scores were measured post-DBE. <h3>Results</h3> A total of 183 patients underwent DBE. Ten elderly patients (50% male, 80% oral) and 72 young patients (43% male, 79% oral) received propofol respectively whilst 25 elderly patients (44% male, 80% oral) and 76 young patients (51% male, 83% oral) received standard sedation. Background demographics, comorbidities and HADS were comparable. There was no difference in the mean dose of propofol used in elderly or young patients (mean 1032 mg vs 1097 mg, p = 0.651) or the procedure time in any group (p = 0.081). The most common indications for DBE were iron deficiency anaemia (57.1%), overt gastrointestinal bleeding (20%) and suspected Crohn’s disease (11.4%) in elderly patients; akin to that in young patients (31.8%, 7.4%, 23.6% respectively). The most common findings at DBE (elderly vs young) were angioectasias (37.1% vs 18.9%, p = 0.025), tumours/masses (17.1% vs 17.6%, p = 1), ulcers (17.1% vs 13.5%, p = 0.593) and a normal examination (22.9% vs 39.2%, p = 0.080). Diagnostic and therapeutic yields were also comparable in all groups (range 60–90%, p = 0.205 and 24–50%, p = 0.054 respectively). There were no complications in elderly patients receiving propofol. One elderly patient receiving standard sedation had a significant troponin rise. Propofol gave lower patient pain, discomfort and distress scores compared to sedation (p &lt; 0.05). <h3>Conclusion</h3> This is the first study to compare sedation types for DBE in the elderly. Our data suggests that not only is safety comparable in the elderly receiving propofol compared to standard sedation during DBE but tolerability is significantly better. This would support the use of propofol sedation for DBE in elderly patients. <h3>Disclosure of Interest</h3> None Declared
Intensified Chemo-Immunotherapy Including up-Front Autologous or Allogeneic Stem Cell Transplantation (SCT) for Young Patients with Newly Diagnosed Peripheral T-Cell Lymphomas: Final Results of a Phase II Multicenter Prospective Clinical Trial
Authors: Paolo Corradini, Umberto Vitolo, Alessandro Rambaldi, Rosalba Miceli, Francesca Patriarca, Andrea Gallamini, Attilio Olivieri, Fabio Benedetti, Giuseppe Todeschini, Giuseppe Rossi, Guido Parvis, Flavia Salvi, Benedetto Bruno, Luca Baldini, Caterina Patti, Giuseppe Milone, Andrés JM Ferreri, Corrado Tarella, Stefano A. Pileri, Anna Dodero
Journal: Blood (2012)
A Machine Learning Based Model to Predict Two-Year Leukemia Free Survival in Cord Blood Transplantation for Acute Leukemia - a Data Mining Study, on Behalf of Eurocord, Cord Blood Committee and the Acute Leukemia Working Party of the EBMT
Authors: Roni Shouval, Annalisa Ruggeri, Myriam Labopin, Mohamad Mohty, Guillermo Sanz, Gerard Michel, Eefke Petersen, Patrice Chevallier, Amal Al-Seraihy, Noel-Jean Milpied, Cristina Diaz de Heredia, William Arcese, Didier Blaise, Vanderson Rocha, Amit Gal, Ron Unger, Frederic Baron, Peter Bader, Eliane Gluckman, Arnon Nagler
Journal: Blood (2015)
Favorable Treatment Alternative for Primary Central Nervous System Lymphoma: Combined Chemotherapy Regimen Consisting of High-Dose Methotrexate, Rituximab and Cytosine-Arabinoside
Authors: Pinar Ataca, Selami Kocak Toprak, Erden Atilla, Pervin Topcuoglu, Meltem Kurt Yuksel, Gulsah Kaygusuz, Isinsu Kuzu, Onder Arslan, Muhit Ozcan, Osman Ilhan, Nahide Konuk
Journal: Blood (2014)
Patients with Severe Factor XI Deficiency Who Have An Inhibitor or IgA Deficiency Can Undergo Uneventful Major Surgery by a Single Infusion of Low Dose Recombinant Factor VIIa and Use of Tranexamic Acid.
Authors: Ophira Salomon, Ilia Tamarin, Tami Livnat, Zeev Horovitz, Joseph Kuriansky, Uriel Martinowitz, Yoram Mor, Uri Seligsohn
Journal: Blood (2008)
Rapid Identification of BCR/ABL1 -like Acute Lymphoblastic Leukemia (ALL) Cases By Quantitative Real Time-PCR (Q-RT-PCR). Generation and Validation of a Predictive Statistical Model
Authors: Sabina Chiaretti, Sara Grammatico, Alfonso Piciocchi, Monica Messina, Anna Lucia Fedullo, Valentina Gianfelici, Grazia Fazio, Nadia Peragine, Maria Paola Martelli, Paola Fazi, Marco Vignetti, Antonella Vitale, Cyril Salek, Gianni Cazzaniga, Anna Guarini, Robin Foà
Journal: Blood (2015)
Oncogenic RAS Enables DNA Damage- and p53-Dependent Differentiation of Acute Myeloid Leukemia Cells in Response to Chemotherapy.
Authors: Mona Meyer, Daniela Rübsamen, Robert K. Slany, Thomas Illmer, Kathleen Stabla, Petra Roth, Thorsten Stiewe, Martin Eilers, Andreas Neubauer
Journal: Blood (2009)
Characteristics of De Novo Acute Leukemia Patients with Glycosylphosphatidylinositol (GPI) Protein-Negative Population of Leukemic Cells.
Authors: Hideyoshi Noji, Tsutomu Shichishima, Masatoshi Okamoto, Kazuhiko Ikeda, Akiko Nakamura, Yukio Maruyama
Journal: Blood (2004)
AB0597 Adaptation of Ucla Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 Questionnaire into Turkish
Authors: M.Y. Tas, P. Keskinoglu, G. Kenar, H. Yarkan Tugsal, B. Zengin, G. Dervis Hakim, G. Can, F. Onen, N. Akkoc, M. Akarsu, M.A. Birlik
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Nearly 90% of patients with scleroderma (SSc) have gastrointestinal tract (GIT) involvement in variable severities and is a challenging process for clinicians. The University of California Scleroderma Clinical Trial Consortium Gastrointestinal Tract 2.0 (UCLA SCTC GIT 2.0) is a questionnaire including 34 items, 7 multi-item scales: reflux, distention/bloating, diarrhea, fecal soilage, constipation, emotional well-being and social functioning. By these parameters, a total GIT score is calculated (1). This scale translated in German, Italian, French, Polish, Spanish, Swedish, Dutch before, they are available in http://www.uclascleroderma.researchcore.org/website (1–3). There is no Turkish version of this scale yet. <h3>Objectives</h3> Our aim is to make translation, cultural adaptation of the UCLA SCTC GIT 2.0 into Turkish, and assess reliability of the scale in patients speaking Turkish. <h3>Methods</h3> UCLA SCTC GIT 2.0 scale was translated into Turkish according to international guidelines and applied to 97 SSc patients. The questionnaire repeated in 29 patients after an interval of 15 days for determining reliability. For internal consistency, Cronbach9s alpha was calculated, reliability coefficient if item deleted and test-retest reliability also determined. External consistency was measured by comparing with the Short Form (SF)-36 by Spearman9s correlation analysis (rho: ≤0.29 weak, 0.30–0.49 middle, ≥0.50 strong). <h3>Results</h3> 97 scleroderma patients were included in this study (female:87.6%, mean age:55.4±11.4). Internal consistency Cronbach9s alpha was calculated as 0.89, reliability coefficient if item deleted was 0.89–0.90. External consistency of UCLA SCTC GIT 2.0 was measured by comparing with the SF-36, correlation was meaningful in medium level (Table 1,2). <h3>Conclusions</h3> UCLA SCTC GIT 2.0 scale had strong internal consistency, good reliability and acceptable validity when adapted into Turkish. Turkish-speaking patients with scleroderma, this scale will be useful to assess GIT symptoms. The basic constraint of our study was, not using image procedures for objective GIT involvement evidences. <h3>References</h3> Khanna D,Reliability and validity of the UCLA SCTC GIT Instrument.Arthritis Rheum,2009. Bae S,Development and validation of French version of the UCLA SCTC GIT Instrument.Clin Exp Rheumatol, 2011. Meijs J,Translation,cross-cultural adaptation,and validation of the UCLA SCTC GIT 2.0 into Dutch. Clin Exp Rheumatol,2014. <h3>Disclosure of Interest</h3> None declared
Human-Cl Rhfviii Effectively and Safely Prevents Bleeding Episodes in Previously Treated Adult Patients with Severe Haemophilia A
Authors: Sigurd Knaub, Toshko Lissitchkov, Kingsley Hampton, Mario Von Depka, Savita Rangarajan, Charles R.M. Hay, Edward GD Tuddenham, Peter Collins, Katharina Holstein, Angela Huth-Kühne, Ingrid Pabinger, Johannes Oldenburg, Johann Bichler
Journal: Blood (2012)
Phase I Trial of the Base – Excision Repair Blocker Methoxyamine (TRC-102) Combined with Fludarabine in Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) and Lymphoid Malignancies
Authors: Paolo Caimi, Brenda Cooper, Basem M. William, Erica L Campagnaro, Richard J. Creger, Manuel Afable, Yan Xu, John Pink, Afshin Dowlati, Hillard M. Lazarus, Marcos de Lima, Stanton L. Gerson
Journal: Blood (2014)
PTU-033 Endoscopic Mucosal Resection of Adenomas and Sessile Serrated Polyps, is there a Difference in Complication Rates?
Authors: R Kassam, J Subhani
Journal: Gut (2016)

<h3>Introduction</h3> Introduction: within a regional, DGH based, EMR service, we evaluated whether there is a difference in the complication rate of EMR of adenomas and SSA/P’s. <h3>Methods</h3> Method: from January 2007 to February 2016 we prospectively collected data for a single endoscopist (a consultant gastroenterologist, within our institution), for EMR of all large (&gt;19mm) non-pedunculated polyps. A standard EMR technique was used in all patients, a lifting solution consisting of colloid, methylene blue and adrenaline was injected into the submucosal plane. Appropriately lifting lesions were removed with the use of diathermy through a range of standard snare’s. A CONMED diathermy unit using Endocut setting was used for all EMR’s. Lesions were removed either en bloc or piecemeal dependent upon the safety of either resection technique. Following snare resection any residual polyp tissue was treated with APC. Following uncomplicated EMR’s patients were discharged home with two follow up telephone interviews with a sister in the endoscopy unit scheduled for day 1 and 14 post procedure assessing for complications. Adverse events recorded included perforation, late bleeding or admission. A “site check” was routinely performed at 3 months and if clear at 12 months following the EMR, to assess for recurrence. Histological analysis was carried out by a GI pathologist at our hospital, sessile serrated lesions were classified as per the WHO (2010) classification:<sup>1</sup> SSA/P’s without cytological dysplasia, SSA/P’s with cytological dysplasia, traditional serrated adenomas and hyperplastic polyps. <h3>Results</h3> A single endoscopist attempted 386 adenoma resections, completing 379 of these. 3 (0.8%) perforations were diagnosed. 20 (5.2%) late bleeds occurred in the adenoma group, 12 (3.1%) of patients with late bleeding required admission. Recurrence in the adenoma group was 10.9% at 12 months(249 patients have completed there 1 year follow up to date). During the same period the same endoscopist attempted the resection of 19 SSP’s. In this group 3 (16.7%) perforations were diagnosed, there was the same number of patients with delayed bleeding but only 2 (11.1%) patients required admission for bleeding. Recurrence of SSP’s at 12 months 0%(5 patients have completed their 1 year follow up colonoscopy to date). <h3>Conclusion</h3> Though a clear difference in size of the cohorts, our data demonstrates a strikingly higher rate of perforations in the SSP group. We note no significant difference in complication rates was observed in a large prospective, multicentre study of 2000 lesions.<sup>2</sup> <h3>References</h3> 1 Snover DC, <i>et al</i>. Serrated polyps of the colon and rectum. WHO Classification Tumours of Digestive System. 2010:160–165. 2 Pellise M, <i>et al</i>. EMR for large serrated lesions in comparison with adenomas: a prospective multicentre study of 2000 lesions. <i>Gut</i> online first, January 2016. <h3>Disclosure of Interest</h3> None Declared
Prevalence of T315I, Dasatinib-Specific Resistant Mutations (F317L, V299L, and T315A), and Nilotinib-Specific Resistant Mutations (P-loop and F359) at the Time of Imatinib Resistance in Chronic-Phase Chronic Myeloid Leukemia (CP-CML).
Authors: Michael W.N. Deininger, Michael J. Mauro, Yousif Matloub, Ritwik Sinha, Lynn Ploughman, David Liu, Jerald Radich
Journal: Blood (2008)
SP0048 What Are Nanoparticles: Physics for Medical Doctors
Authors: A. Shah
Journal: Annals of the Rheumatic Diseases (2016)

Nanotechnology has improved the medical world broadly rheumatology specifically through a number of innovative applications used to enhance diagnostics through imaging and therapeutics through enhanced drug delivery. In order to have a better understanding of nanomedicine, however it is helpful to review the basic chemistry and quantum physics that serve as the basic fundamental science of this technology. The building blocks of the nanoworld are atoms as well as the electromagnetic forces between them are the basic forces that give nanomaterials their properties These atoms, in particular carbon, are then shaped into a variety of structures including buckyballs, carbon nanotubes and nanowires that comprise much of todays nanotechnology. In addition thermal agitation as well as cohesion between atoms and molecules serve critical roles in contributing to unique nanomaterial characteristics. Finally, light, namely viewed as a stream of particles called photons, plays a critical role in nanomedicine. Electron microscopy and scanning tunneling microscopy are only two examples of exploiting photons at the nanoscale in order to enhance the role of nanomedicine in medical imaging. <h3>Disclosure of Interest</h3> None declared
PWE-103 Participation, Positivity and Outcomes in The Nepali Community Invited for Bowel Cancer Screening – A Feasibility Study
Authors: HE Seaman, J Snowball, P Butler, J Underwood, H Bruce
Journal: Gut (2016)

<h3>Introduction</h3> The NHS Bowel Cancer Screening Programme (BCSP) offers biennial screening for all adults in England aged 60–74 years using a guaiac-based faecal occult blood test (gFOBt). This feasibility study investigated anecdotal evidence that people who originate from Nepal account for a higher than expected proportion of gFOBt-positive subjects who have a normal outcome at follow-up colonoscopy (false-positive). The BCSP Southern Hub serves several geographical areas with relatively high proportions of Nepali subjects (<i>e.g.</i> Aldershot, Reading and Ashford). <h3>Methods</h3> Data for subjects aged 60–74 invited for screening in the Southern Hub (roll-out to September 2014) were extracted from the BCSP database (BCSS). Because information about subjects’ ethnicity is not recorded on BCSS, Nepali subjects were identified using an algorithm that was based on surname and postcode of residence (subject residing in an area where ≥8% of the BCSP-invited population had a Nepali surname). Data on uptake, gFOBt-positivity and false-positivity were compared between Nepali and non-Nepali men and women invited for screening. <h3>Results</h3> We identified 5,274 Nepali subjects (43.5% women) amongst the 6,218,071 subjects invited for screening during the study period. Compared with the non-Nepali population, uptake of screening was significantly higher amongst Nepalis (61.9% vs. 58.3%; odds ratio [OR] 1.16, 95% Confidence Interval [95%CI] 1.10,1.23), more so amongst Nepali men (OR 1.26, 95%CI 1.17,1.35) than women (OR 1.09, 95%CI 1.00,1.19). Positivity was high in the Nepali population (7.6% vs. 2.0%; OR 4.01, 95%CI 3.53,4.57) and higher for women (OR 5.13, 95%CI 4.22,6.23) than men (OR 3.20, 95%CI 2.69,3.81). False-positivity was markedly higher in the Nepali population (OR 2.37 95%CI 1.77,3.18). More than half of gFOBt-positive Nepali women (50.6%) had a normal outcome at colonoscopy (false-positive), compared with 24.4% in non-Nepali women (OR 3.18 95%CI 2.09,4.84). The proportion of Nepali men with a false-positive outcome was also greater than amongst non-Nepali men (OR 1.75, 95%CI 1.12,2.75). <h3>Conclusion</h3> Compared with non-Nepali gFOBT-positive subjects, false-positivity was high in the Nepali community living in the south of England. The reasons for high false-positivity, implications for colonoscopy resource and exposure of subjects to unnecessary risk will be addressed in further work. The study area will be extended to include other Nepali communities living in London and a validation exercise will be undertaken to test the algorithm used to identify Nepali subjects. <h3>Disclosure of Interest</h3> None Declared
Lineage-Specific Sox7 Expression In Hematopoietic Progenitor Cells Derived From Human Umbilical Cord Blood
Authors: HaiXia Wan, Howard C.H. Chow, Tsz-Kan Fung, Kin-Pong Fan, Anders S.Y. Wong, Raymond Liang, Anskar Y.H. Leung
Journal: Blood (2010)
Characteristics and Outcome Of Myelodysplastic Syndromes (MDS) Patients With Autoimmune Diseases
Authors: Rami S Komrokji, Austin G Kulasekararaj, Najla H Al Ali, Shahram Y Kordasti, Emily Bart-smith, Craig Benjamin, Eric Padron, Ling Zhang, Jeffrey E Lancet, Alan List, Ghulam J Mufti, Pearlie K Epling-Burnette
Journal: Blood (2013)
The Expression of CD56 Is Frequently Accompanied with the Expression of Neuronal Cell Markers and Its Down-Regulation Is Induced by IL-6 in Human Myeloma Cells.
Authors: Mohd S. Iqbal, Ken-ichiro Otsuyama, Karim Shamsasenjan, Saeid Abroun, Jakia Amin, Abul Islam, Michio M. Kawano
Journal: Blood (2007)
Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model
Authors: Shang-Chun Guo, Shi-Cong Tao, Wen-Jing Yin, Xin Qi, Ting Yuan, Chang-Qing Zhang
Journal: Theranostics (2016)

Chronic wounds have become an economic, social, and public health burden and need advanced treatment. Platelet-rich plasma (PRP) has been used extensively in treatment of chronic wounds because it contains an abundance of growth factors secreted by platelets. The exosomes derived from PRP (PRP-Exos) have been proven to encapsulate principal growth factors from platelets. This study is the first to show that these exosomes may exert the function of PRP. PRP-Exos can effectively induce proliferation and migration of endothelial cells and fibroblasts to improve angiogenesis and re-epithelialization in chronic wounds. We regulated YAP to verify the PRP-Exos-dependent effect on fibroblast proliferation and migration through YAP activation. In vivo, we observed the cutaneous healing process in chronic wounds treated with PRP-Exos in a diabetic rat model. We provide evidence of the probable molecular mechanisms underlying the PRP effect on healing of chronic ulcers and describe a promising resource of growth factors from exosomes without species restriction.
The Role of PET-CT for the Diagnosis of Infections in Hemato-Oncological Patients with Persistent Febrile Neutropenia
Authors: Anat Gafter-Gvili, Mical Paul, Hanna Bernstine, Liat Vidal, Ron Ram, Pia Raanani, Moshe Yeshurun, Boaz Tadmor, Ofer Shpilberg, David Groshar
Journal: Blood (2011)