tbuckley/cabot-search huggingface dataset:
Abstract 13493: Intracellular Cholesterol Transport Proteins Enhance Hydrolysis of HDL-delivered Cholesteryl Esters and Facilitate Preferential Elimination of Resulting Cholesterol Into Bile as Bile Acids
Authors: Jinghua Bie, Jing Wang, Shobha Ghosh
Journal: Circulation (2015)

HDL-associated cholesterol, &gt;80% esterified (HDL-CE) entering the hepatocyte via SR-BI can have multiple fates: 1) re-secretion as nascent HDL; 2) re-esterification and either storage of resulting CE or secretion of CE as VLDL; 3) secretion of free cholesterol into bile; and 4) conversion to and secretion of bile acids into bile. While fates 1 and 2 will lead to recirculation of HDL-CE returning to the liver from the periphery including plaque associated macrophage foam cells, fates 3 and 4 will lead to final elimination of cholesterol from the body and would be anti-atherogenic. Although we earlier identified cholesteryl ester hydrolase (CEH) as the hepatic enzyme responsible for the hydrolysis of SR-BI delivered HDL-CE, intracellular factors affecting the directional movement of HDL-derived FC remain undefined. In the present study, we examined the hypothesis that intracellular cholesterol transport proteins (SCP-2 and FABP1) not only facilitate CEH mediated hydrolysis of HDL-CE but also enhance elimination of cholesterol into bile. Primary C57BL/6 mouse hepatocytes were used and expression of CEH, FABP1 or SCP2 was modulated by using respective adenoviruses; AdLacZ was used as control. Over-expression of SCP2 or FABP1 significantly increased hydrolysis of HDL-[ 3 H]-CE (A) and reduced the re-secretion of HDL-derived cholesterol as nascent HDL (B). However, over-expression of SCP2 or FABP1 increased the secretion of cholesterol from HDL-[ 3 H]-CE as bile acids (C). Flux of HDL-[ 3 H]-CE into bile was monitored in vivo using C57BL/6 mice. Similar to the effects seen in vitro, adenovirus-mediated over-expression of FABP1 and SCP2 significantly increased the flux of cholesterol from HDL-[ 3 H]-CE to bile acids (D). Taken together, these studies demonstrate that SCP2 and FABP1 facilitate the preferential movement of HDL-associated cholesterol to bile for final elimination from the body. Studies are in progress to establish the anti-atherogenic role of these proteins
PTH-182 Atopic history and ige levels – are they a useful adjunct in diagnosing eosinophilic oesophagitis? – a study of investigations and treatment response in the adult population of a district general hospital: Abstract PTH-182 Table 1
Authors: V Nadesalingam, R Nathwani, M Yalchin, I Al Bakir, R Swamy, DL Morris
Journal: Gut (2015)

<h3>Introduction</h3> Eosinophilic Oesophagitis (EoE) is an increasingly common cause of dysphagia. Most reported series are from specialist centres. We present a series of adult patients with EoE from a typical UK district general hospital, describing their demographics, investigations and treatment response. We also highlight the role of Total IgE measurement in supporting the diagnosis. <h3>Method</h3> Patients were selected retrospectively by reviewing biopsies from endoscopies performed over a 4 year period (2009–2012). Diagnosis of EoE was confirmed by having oesophageal symptoms, 15 or more eosinophils per high powered field and absence of an alternative diagnosis. <h3>Results</h3> 73 cases were identified, 52 were male and 21 female. Average age at presentation was 51 years. Presenting symptoms included dysphagia (n = 58), bolus obstruction (n = 34) and reflux (n = 19). We estimate EoE is responsible for 3% of cases of dysphagia presenting to our hospital. 49 patients were asked about atopy history. 37 (76%) had a positive history for at least one condition; hay fever (n = 19), asthma (n = 18), eczema (n = 8), urticarial (n = 4) and/or dermatitis (n = 1). Total IgE was measured in 31/65 (48%) patients who had blood tests. 30 (97%) had either a strongly positive (n = 27) or positive (n = 3) total IgE reading, defined as total IgE &gt; 0.35 kU/L. Levels ranged from 5–520 kU/L. 23/31 (74%) of these cases had history of atopy. Food mix allergy testing was done in 29/73 with a positive result in 16. First line treatments prescribed were documented in 62 cases as shown: Those not responsive to combination therapy of PPI and swallowed steroid as first line agents had antihistamines, domperidone or cromoglycate added. <h3>Conclusion</h3> EoE is a common and treatable cause of dysphagia. This study supports that adult EoE patients have atopic coexistence, more often reported in paediatric studies. Total IgE measurement may be useful in supporting a diagnosis. Only 3 previous studies have reported total IgE levels in EoE patients. Food specific radioallergosorbent testing (RAST) may have a role in management of EoE with dietary exclusion a treatment option. This is well described in the paediatric population but less so in adults – only one adult study has described use of food specific RAST in adult EoE patients. Given the variability in treatment approach to EoE there is a clear need for guidelines to standardise the care of EoE. <h3>Disclosure of interest</h3> None Declared.
Peter Edward Baldry
Authors: Mike Cummings
Journal: BMJ (2016)

Peter Edward Baldry, father of the former conservative MP Sir Tony Baldry, was born in New Malden, Surrey. He was educated at King’s College Wimbledon, followed by reading medicine at Barts from 1938 to 1943. As a medical student during the second world war, he spent many nights on the roof of St Paul’s, fire watching. He witnessed first hand the start of the antibiotic era, and his early medical career …
Novel endoscopic treatment for colocutaneous fistula after severe acute pancreatitis: filling with a polyglycolic acid sheet
Authors: Yuichi Takano, Eiichi Yamamura, Yuichiro Kuroki, Naotaka Maruoka, Masatsugu Nagahama, Hiroshi Takahashi
Journal: Endoscopy (2015)

The formation of gastrointestinal fistulas has been reported as a rare complication associated with late-stage, severe, acute pancreatitis. This condition is difficult to treat and often requires surgery [1]. Here we report on a successful case of endoscopically implanted polyglycolic acid (PGA) sheets (Neoveil; Gunze Co., Tokyo, Japan) being used to repair a fistula that had formed between the colon and skin.
Surveillance of human salmonellosis in Bulgaria, 1999-2004: trends, shifts and resistance to antimicrobial agents
Authors: G Asseva, P Petrov, I Ivanov, T Kantardjiev
Journal: Eurosurveillance (2006)

This article analyses the distribution of resistant salmonella and resistance mechanisms among the most frequently encountered serotypes in Bulgaria. Culture, biochemical tests and serotyping were used for identification. Screening for resistance to 14 antimicrobial agents with the standard Bauer-Kirbi disk-diffusion method. The double disk synergy method was used to determine production of extended-spectrum a-lactamases (ESBL). Transfer of genes coding for ESBLs with experimental conjugation. Specific primers were used for PCR detection of bla-CTX-M, bla-SHV and bla-TEM. 245 resistant salmonella strains were determined in our study; the majority originated from sporadic cases of human illness or asymptomatic infection and the remaining 23 were isolated from outbreaks. 79 producers of ESBL were detected: 5 S. Enteritidis, 1 S. Typhimurium, 9 S. Isangi and 62 S. Corvallis with types of enzymes: CTX-M3, TEM and SHV. Gene coding for extended-spectrum a- lactamases were successfully transferred into a recipient Escherichia coli C1A strain simultaneously with genes coding for resistance to aminoglycosides and sulphonamides (for bla-CTX-M3) and gene coding for resistance to aminoglycosides and chloramphenicol (for bla-SHVand bla-TEM). PCR amplification revealed bla-CTX-M3 genes in S. Enteritidis, and bla-SHV and bla-TEM in S. Corvallis. Salmonellae have revealed increasing resistance to all clinically important groups of antimicrobial agents. Bulgaria is the first country in the world where ESBL in serotype Corvallis has been reported. A wide diversity of resistance genes is found among the leading serotypes of salmonella causing human disease in Bulgaria.
Ann Arbor Stage Is the Most Important Predictor of Survival for Refractory and Relapsed HIV-Associated Lymphoma Enrolled in a Program of High Dose Therapy and Autologous Peripheral Blood Stem Cell Transplantation.
Authors: Alessandro Re, Chiara Cattaneo, MariaGrazia Michieli, Salvatore Casari, Michele Spina, Maurizio Rupolo, Bernardino Allione, Piero Ferremi, Arnalda Lanfranchi, Mauro Mazzuccato, Gianpiero Carosi, Umberto Tirelli, Giuseppe Rossi
Journal: Blood (2004)
71P Evolution of neoadjuvant chemotherapy (NAC) in locally advanced HER2-positive breast cancer over 10 years in Hong Kong
Authors: J.W.Y. Chiu, R. Leung, V. Tang, I. Cheuk, J. Lo, H. Wong, G. Kwok, D. Suen, T. Yau, A. Kwong
Journal: Annals of Oncology (2015)
Polyphosphate is a novel cofactor for regulation of complement by a serpin, C1 inhibitor
Authors: Lakshmi C. Wijeyewickrema, Emilie Lameignere, Lilian Hor, Renee C. Duncan, Toshikazu Shiba, Richard J. Travers, Piyushkumar R. Kapopara, Victor Lei, Stephanie A. Smith, Hugh Kim, James H. Morrissey, Robert N. Pike, Edward M. Conway
Journal: Blood (2016)
Primary spontaneous pneumothorax: a cohort study of VATS with talc poudrage
Authors: Giuseppe Cardillo, Oliver J Bintcliffe, Francesco Carleo, Luigi Carbone, Marco Di Martino, Brennan C Kahan, Nick A Maskell
Journal: Thorax (2016)

<h3>Background</h3> Video-assisted thoracoscopic surgery (VATS) is an increasingly common treatment for recurrent or persistent primary spontaneous pneumothorax (PSP). Surgery usually involves diffuse treatment of the pleura and possible targeted therapy to areas of bullous disease. The purpose of this large cohort study was to examine incidence of recurrence after VATS and identify predictors of outcome. <h3>Methods</h3> Patients undergoing VATS for PSP at a single centre between 2000 and 2012 were prospectively enrolled. All patients underwent talc poudrage. Targeted surgical techniques were used based on presence of air leak and Vanderschueren9s stage. Patients had clinical and radiological follow-up for at least 2 years (median 8.5 years). <h3>Results</h3> 1415 patients with PSP underwent VATS with talc poudrage. The most frequent indications were recurrent pneumothorax (92.2%) and persistent air leak (6.5%). The complication rate was 2.0% of which 1.7% was prolonged air leak. There was no mortality. Median length of stay was 5 days. Recurrent pneumothorax occurred in 26 patients (1.9%). At the time of surgery, 592 patients smoked (43%) and they had a significantly higher incidence of recurrence (24/575, 4.2%) than non-smokers (2/805, 0.2%), p&lt;0.001. The incidence of recurrence in those undergoing bullae suturing (3.8%, n=260) was significant higher than those undergoing poudrage alone (0.3%, p=0.036). <h3>Conclusion</h3> The marked difference in recurrence between smokers and non-smokers suggests this as an important predictor of outcome. This study demonstrates a low incidence of recurrence and complications for patients with PSP undergoing VATS with talc poudrage. Talc poudrage requires prospective comparison with pleurectomy and mechanical abrasion.
Anticholinergic activity of two tricyclic antidepressants
Authors: B Blackwell, A Stefopoulos, P Enders, R Kuzma, A Adolphe
Journal: American Journal of Psychiatry (1978)

Using a double-blind crossover Latin square design, the authors evaluated the peripheral anticholinergic and central nervous system effects of three dose levels of two tricyclic antidepressants in female volunteers. Results showed that 5 hours after drug administration, desipramine (50 and 100 mg) caused significantly less reduction in salivation than did amitriptyline. Amitriptyline produced more sedation (Clyde Mood Scale) and a greater number of subjective complaints than did desipramine. These results are consistent with anticholinergic profiles from animal experiments and suggest that clinically meaningful differences may exist among tricyclic antidepressants.
Renal medullary necrosis.
Authors: R M Friedenberg, H Bergman
Journal: BMJ (1970)

Renal Medullary NecrosisFriedreich first described renal medullary necrosis in 1877 in a man with an enlarged prostate and hydronephrosis.'The lesion is a circumscribed, wedge-shaped necrosis of the medullary pyramids especially affecting the distal parts of the papillae.It is usually greyish-yellow in colour, and micro- scopically it consists of acellular necrotic material separated from the remainder of the parenchyma by a zone of acute inflammation.While in most cases there is a superimposed acute pyelonephritis, the condition may occur in the absence of infection, and the alternative name necrotizing papillitis is to be deprecated.The necrotic papillae may slough off into the urine, leaving a ragged surface at the point of separation.Most patients die of rapidly progressive renal failure, but some have survived.2The condition is described mainly in adults, and the two usual predisposing causes are diabetes mellitus and obstruction of the urinary tract, both being frequently complicated by acute pyelonephritis.3More recently medullary necrosis has
Oxygen desaturation during a 6-min walk identifies a COPD phenotype with an increased risk of morbidity and mortality
Authors: Paul L. Enright
Journal: European Respiratory Journal (2016)

M. Waatevik and co-investigators from Bergen, Norway, have added to the evidence that smokers with airflow limitation who have oxygen desaturation during a 6-min walk test (6MWT) are: 50% more likely to have respiratory exacerbations; more rapidly lose lung function; and have twice the mortality rate when compared with patients who do not desaturate [1]. Uniquely, they also found that "desaturators" were much more likely to become cachectic (lose fat-free body mass) during follow-up. 6MWD: patients who desaturate have higher morbidity/mortality rates when compared with those who do not desaturate <http://ow.ly/J63B3006JCg>
Inhalant abuse in an Indian boarding school
Authors: M F Schottstaedt, J W Bjork
Journal: American Journal of Psychiatry (1977)

The authors describe inhalant abuse among children in an American Indian elementary boarding school. They discuss the initial interventions made to control this problem, such as providing a lower adult-child ratio and improving staff morale and child management skills and developing a volunteer program to improve the quality of the children's experience after school hours. They suggest that such preventive efforts be made early to interrupt the destructive cycle of dependence on external agents.
PO20VOXEL-BASED PARAMETRIC RESPONSE USING THE SERIAL MEASUREMENT OF APPARENT DIFFUSION COEFFICIENT FOR PREDICTING SUBSEQUENT TREATMENT RESPONSE PATTERN IN PATIENTS WITH GLIOBLASTOMA
Authors: Ra Gyoung Yoon, Ho Sung Kim, Dae Yoon Kim, Gil Sun Hong, Sang Joon Kim
Journal: Neuro-Oncology (2015)

INTRODUCTION: Determining treatment response after concurrent chemoradiotherapy (CCRT) in glioblastoma is important to minimize morbidity and the financial burden associated with prolonged ineffective treatment. We performed this study to determine the diagnostic superiority of apparent diffusion coefficient (ADC) parametric response (ADCPR) for predicting glioblastoma treatment response, compared to single time point measurement. METHOD: 50 post-treatment glioblastoma patients were enrolled. ADCPR was calculated from serial ADC maps acquired before and at the time of first detection of an enlarged contrast-enhancing lesion on voxel-by-voxel basis. The percentage-decrease in ADCPR and 10% histogram cutoff of ADC (ADC10) were compared as potential predictors of treatment response at subsequent 3 months and 1 year follow-up studies. RESULTS: The percentage-decrease in ADCPR was significantly higher in progression group than in stable-response group both at 3 months follow-up studies (p <.001) and at 1 year follow-up studies (p = 0.003-0.002). ADCPR significantly improved area under the receiver operating characteristic curve from 0.67 to 0.88 and from 0.70 to 0.92 for both readers, respectively, compared to ADC10 at 3 months follow-up studies but did not significantly improve at 1 year follow-up studies. The interreader agreement was higher for ADCPR than ADC10 (intraclass correlation coefficient, 0.93 versus 0.86). CONCLUSION: Voxel-based ADCPR appears to be a superior imaging biomarker than single time point measurement of ADC particularly for predicting early tumor progression in patients with glioblastoma.
Abstract 13411: Overexpression of Interleukin-10 in Murine Macrophages for Anti-Inflammatory Therapy in Myocarditis
Authors: Oliver Zimmermann, Juliane M Wiehe, Katrin Vogt, Magdalena Bienek-Ziolkowski, Wolfgang Rottbauer, Stefan Goeser, Renate Ottl, Hugo A Katus, Ziya Kaya
Journal: Circulation (2010)

Objectives: Myocarditis is a multifactorial disease and macrophages play an essential role in the pathogenesis of myocardial inflammation. A specific and approved therapy is often missing or limite...
City-Smoke and Medical Chaos
Authors: J. R. E.
Journal: Annals of Internal Medicine (1969)

Editorials1 September 1969City-Smoke and Medical ChaosJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-71-3-655 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptA time-worn boast in Philadelphia has been to the effect that one quarter of all people in the United States live within 90 miles of the statue of Billy Penn on top the tower of City Hall. Such provincial bragging is not a joke today, even to New Yorkers; rather it is a cause for civic, social, and even medical, apprehension. Daily we wrestle with the frustrations of traffic-clogged streets and expressways, inadequate and ageing commuter services, rising taxes and a deteriorating system of public education, violence and poverty, polluted waters and smoke-filled air, dirt and ugliness. Yet it has...References1. Urban Air Pollution with Particular Reference to Motor Vehicles. Report of a WHO Expert Committee. World Health Organization Technical Report Series No. 410, Geneva, 1969, 53 pp. Google Scholar2. LASHOF JC: Medical care in the urban center (editorial). Ann. Intern. Med. 68: 242, 1968. LinkGoogle Scholar3. The New York Times, June 29, 1969. Google Scholar4. Two weeks after Dr. Egeberg's appointment, President Nixon endorsed a "White House Report on Health Care Needs" as released by Secretary Finch and Assistant Secretary Egeberg (New York Times July 11, 1969). This Report emphasized the gravity of the situation, endorsed many of the goals previously announced by Secretary Finch, and proposed means to deal with the problems—means that indeed would involve both the public and the private sectors. President Dwight Wilbur of the AMA promised cooperation and that organization, at its annual meeting later in the month, endorsed a plan to improve the health care of the poor through local societies and the use, if necessary, of federal funds. The best means and the will to achieve these goals in the health care crisis remain, of course, the heart of the problem. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByJ. Russell Elkinton, M.D., M.A.C.P.: A TributeMARSHALL N. FULTON, M.D. 1 September 1969Volume 71, Issue 3Page: 655-657KeywordsTaxes Issue Published: 1 September 1969 PDF DownloadLoading ...
Lenalidomide Maintenance Significantly Improves Progression-Free Survival (PFS) in Patients with Chemosensitive Relapse of Diffuse Large B-Cell Lymphoma (DLBCL) Who Are Not Eligible for Autologous Stem Cell Transplantation (ASCT) or Experienced Relapse after Transplantation: Results of a Multicentre Phase II Trial
Authors: Andrés J.M. Ferreri, Marianna Sassone, Marianna Chiozzotto, Michele Spina, Alessandra Tucci, Alice Di Rocco, Alberto Fabbri, Caterina Stelitano, Maurizio Frezzato, Renato Zambello, Giovanni Bertoldero, Chiara Rusconi, Annalisa Arcari, Lydia Scarfo, Silvia Govi, Maurilio Ponzoni, Francesco Zaja
Journal: Blood (2015)
Higher Leukemia Free Survival after Post-Induction Hematopoietic Cell Transplantation Compared to Consolidation Therapy in Patients >60 Years with Acute Myelogenous Leukemia (AML): Report from the AML 2004 East German Study Group (OSHO)
Authors: Dietger Niederwieser, Haifa Kathrin Al-Ali, Rainer Krahl, Christoph Kahl, Hans-Heinrich Wolf, Ute Kreibich, Vladan Vucinic, Detlev Haehling, Ute Hegenbart, Alwin Kraemer, Carsten Hirt, Norma Peter, Bernhard Opitz, Axel Florschütz, Kolja Reifenrath, Antje Schulze, Niklas Zojer, Sebastian Scholl, Christian Jakob, Christian Junghanss, Wolfram Pönisch, Simone Heyn, Herbert G. Sayer, Andreas Hochhaus, Thomas Heinicke, Thomas Fischer, Georg Maschmeyer, Peter Dreger
Journal: Blood (2014)
Intercellular Communication Between Extracellular Vesicles and Murine Marrow Cells Is Influenced By Circadian Rhythm
Authors: Laura R. Goldberg, Yan Cheng, Shannon Johnson, Mandy Pereira, Sicheng Wen, Michael DelTatto, Elaine Papa, Yanhui Deng, Connor Stewart, Jason M Aliotta, Mark S Dooner, Peter J Quesenberry
Journal: Blood (2014)
Methylphenidate in the treatment of aggression in two patients with antisocial personality disorder
Authors: A Y Stringer, N C Josef
Journal: American Journal of Psychiatry (1983)

Two hospitalized patients with antisocial personality disorder (by DSM-III) and histories of childhood attention deficit disorder became less aggressive during trials of methylphenidate. The authors suggest a link between the childhood disorder and one subgroup of antisocial personality disorder.