tbuckley/cabot-search huggingface dataset:
Antihistamines in Bronchial Asthma
Authors: H. Herxheimer
Journal: BMJ (1949)

The beneficial action of antihistamines in hay-fever, perennial rhinitis, and urticaria is undisputed, but their use in human asthma has been doubted.In this paper experimental and clinical evidence is presented that the anti- histamines are of considerable value in the treatment of this condition.Experimental Evidence Method
Secondary Prevention by Raising HDL Cholesterol and Reducing Triglycerides in Patients With Coronary Artery Disease
Journal: Circulation (2000)

Background —Coronary heart disease patients with low high-density lipoprotein cholesterol (HDL-C) levels, high triglyceride levels, or both are at an increased risk of cardiovascular events, but the clinical impact of raising HDL-C or decreasing triglycerides remains to be confirmed. Methods and Results —In a double-blind trial, 3090 patients with a previous myocardial infarction or stable angina, total cholesterol of 180 to 250 mg/dL, HDL-C ≤45 mg/dL, triglycerides ≤300 mg/dL, and low-density lipoprotein cholesterol ≤180 mg/dL were randomized to receive either 400 mg of bezafibrate per day or a placebo; they were followed for a mean of 6.2 years. The primary end point was fatal or nonfatal myocardial infarction or sudden death. Bezafibrate increased HDL-C by 18% and reduced triglycerides by 21%. The frequency of the primary end point was 13.6% on bezafibrate versus 15.0% on placebo ( P =0.26). After 6.2 years, the reduction in the cumulative probability of the primary end point was 7.3%, ( P =0.24). In a post hoc analysis in the subgroup with high baseline triglycerides (≥200 mg/dL), the reduction in the cumulative probability of the primary end point by bezafibrate was 39.5% ( P =0.02). Total and noncardiac mortality rates were similar, and adverse events and cancer were equally distributed. Conclusions —Bezafibrate was safe and effective in elevating HDL-C levels and lowering triglycerides. An overall trend in a reduction of the incidence of primary end points was observed. The reduction in the primary end point in patients with high baseline triglycerides (≥200 mg/dL) requires further confirmation.
The role of oral hygiene in head and neck cancer: results from International Head and Neck Cancer Epidemiology (INHANCE) consortium
Authors: D. Hashim, S. Sartori, P. Brennan, M.P. Curado, V. Wünsch-Filho, K. Divaris, A.F. Olshan, J.P. Zevallos, D.M. Winn, S. Franceschi, X. Castellsagué, J. Lissowska, P. Rudnai, K. Matsuo, H. Morgenstern, C. Chen, T.L. Vaughan, J.N. Hofmann, G. D'Souza, R.I. Haddad, H. Wu, Y.-C. Lee, M. Hashibe, C.La Vecchia, P. Boffetta
Journal: Annals of Oncology (2016)
272PD BRCA1/2 mutation frequency and patterns of treatment response in Asian women with ovarian, primary peritoneal or fallopian tube carcinoma (OPFC): experience from an Asian cancer centre
Authors: V.Y.M. Heong, P.Y. Ong, L. Yi Wan, S.E. Lim, S.C. Lee, D.S. Tan
Journal: Annals of Oncology (2015)
Abstract PR10: A DNA hypomethylation signature predicts novel antitumor activity of LSD1 inhibition in SCLC
Authors: Helai Mohammad, Ryan Kruger
Journal: Cancer Research (2016)

Abstract Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in epigenetic machinery have become a major focus for new targeted therapies. The current report describes the discovery and biological activity of a cyclopropylamine containing inhibitor of Lysine Demethylase 1 (LSD1), GSK2879552. This small molecule is a potent, selective, orally bioavailable, mechanism-based irreversible inhibitor of LSD1. A proliferation screen of cell lines representing a number of tumor types indicated that small cell lung carcinoma (SCLC) is sensitive to LSD1 inhibition. The subset of SCLC lines that undergo growth inhibition in response to GSK2879552 exhibit DNA hypomethylation of a signature set of probes suggesting this may be used as a predictive biomarker of activity. This targeted mechanism coupled with a novel predictive biomarker make LSD1 inhibition an exciting potential therapy for SCLC, a highly prevalent, rarely cured, tumor type representing approximately 15% of all lung cancers. Citation Format: Helai Mohammad, Ryan Kruger. A DNA hypomethylation signature predicts novel antitumor activity of LSD1 inhibition in SCLC. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr PR10.
Investigation of human infections with Salmonella enterica serovar Java in Scotland and possible association with imported poultry
Authors: D  J Brown, H Mather, L  M Browning, J  E Coia
Journal: Eurosurveillance (2003)

PFGE analysis of S. Java strains (29 from humans, 30 from poultry meat) showed two major clusters. All isolates from poultry imported from the Netherlands belonged to Cluster A, which also comprised 10 human isolates. Thirty-one of the 37 isolates in this cluster had an identical JavX1 pattern, similar to the X8 profile of a particular S. Java clone predominant in poultry production in several European countries. Cluster B comprised 19 human isolates and two poultry isolates of unknown origin. These results combined with epidemiological data and information on the origins of poultry meat strongly suggested that imported poultry meat is an important source of Java infections in humans in Scotland.
Ultrastructure of Avian Myeloblasts in Tissue Culture&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Bonar, R. A., Parsons, D. F., Beaudreau, G. S., Becker, Caroline, Beard, J. W.
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Ultrastructure of Avian Myeloblasts in Tissue Culture Get access R. A. Bonar, R. A. Bonar Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar D. F. Parsons, D. F. Parsons Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar G. S. Beaudreau, G. S. Beaudreau Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar Caroline Becker, Caroline Becker Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Beard J. W. Beard Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 23, Issue 1, July 1959, Pages 199–225, https://doi.org/10.1093/jnci/23.1.199 Published: 01 July 1959 Article history Received: 23 January 1959 Published: 01 July 1959
The Addition Of Sirolimus To The Gvhd Prophylaxis Regimen In Reduced Intensity Allogeneic Stem Cell Transplantation For Lymphoma: A Multicenter Randomized Trial
Authors: Philippe Armand, Haesook T Kim, Marie-Michele Sainvil, Veronika Bachanova, Steven M. Devine, Edmund K. Waller, Neera Jagirdar, Corey S. Cutler, Vincent T. Ho, John Koreth, Edwin P. Alyea, Steven L. McAfee, Yi-Bin Chen, Robert J. Soiffer, Joseph H. Antin
Journal: Blood (2013)
Psychiatric implications of basic and clinical studies with corticotropin-releasing factor
Authors: P W Gold, G Chrousos, C Kellner, R Post, A Roy, P Augerinos, H Schulte, E Oldfield, D L Loriaux
Journal: American Journal of Psychiatry (1984)

Corticotropin-releasing factor (CRF) is a newly sequenced neuropeptide thought to be a principal stimulus to pituitary corticotropin (ACTH) secretion. Evidence obtained from laboratory animals and primates is reviewed which indicates that CRF not only stimulates the pituitary-adrenal axis but also influences several aspects of CNS function which may be of relevance to psychiatric illness. Clinically, experience in administering ovine CRF to more than 150 individuals shows that CRF can be helpful in resolving differential diagnostic dilemmas in patients with various disorders of the hypothalamic-pituitary-adrenal axis and in furthering an understanding of the pathophysiology of conditions such as Cushing's disease and depression.
Futility
Authors: N L Greengold
Journal: JAMA (2001)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Comparison Between Heterozygous and Homozygous Skin Homografts
Authors: Richmond T. Prehn, Joan M. Main
Journal: JNCI Journal of the National Cancer Institute (1954)

A Comparison Between Heterozygous and Homozygous Skin Homografts Get access Richmond T. Prehn, Richmond T. Prehn National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joan M. Main Joan M. Main National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 1, August 1954, Pages 191–194, https://doi.org/10.1093/jnci/15.1.191 Published: 01 August 1954 Article history Received: 21 April 1954 Published: 01 August 1954
Orbital IgG4-Related Disease Detected by 11C-Methionine PET/CT
Authors: Tomohiko Yamane, Akira Seto, Tomonari Suzuki, Kazuhiro Yokota, Chih-Ping Li, Toshihide Mimura, Ichiei Kuji
Journal: Clinical Nuclear Medicine (2015)

A 64-year-old man presented with a complaint of left exophthalmos. Whole-body 18F-FDG PET/CT showed increased uptake in the soft tissue masses in the orbits, peripancreas, and left renal hilum. 11C-methionine (MET) PET/CT of the head and neck showed increased uptake in the orbits, and the SUVmax of the left orbital lesion was 7.0. The patient was finally diagnosed as IgG4-related disease by the results of increased serum IgG4 and the biopsy of the orbital lesion. Although 11C-MET is generally considered as a tumor-specific tracer, fibrous tissues of IgG4-related disease may be visualized by 11C-MET PET/CT.
Abstract 4766: DNA methylation changes in Lynch syndrome associated colorectal adenomas and carcinomas
Authors: Satu Valo, Sippy Kaur, Ari Ristimäki, Laura Renkonen-Sinisalo, Heikki Järvinen, Jukka-Pekka Mecklin, Minna Nyström, Päivi Peltomäki
Journal: Cancer Research (2015)

Abstract Colorectal cancer (CRC) develops via multiple steps which involve genetic changes, such as mutations in growth-regulatory genes, and epigenetic alterations, such as CpG island hypermethylation. Lynch syndrome (LS) is one of the most common inherited cancer susceptibility syndromes and is associated with inherited defects of the DNA mismatch repair (MMR) genes, which together with other genetic and epigenetic changes are known to accelerate tumorigenesis. In this investigation we explored the timing of CpG island methylation changes in the course of transformation of normal colonic mucosa to pre-cancerous and cancerous lesions in genetically predisposed individuals. Colorectal neoplastic lesions including low-grade adenomas, high-grade adenomas and carcinomas together with matching normal tissue were gathered from 43 LS mutation carriers enrolled in colonoscopy surveillance. Frequency of CpG island methylator phenotype (CIMP) in different tumor types was analyzed with the methylation-specific multiplex ligation-dependent probe amplification test (MS-MLPA) which detects simultaneously the methylation status of eight CIMP marker genes. Additionally, we analyzed the methylation status of seven selected tumor suppressor genes previously associated with early colon oncogenesis. Immunohistochemistry was used to detect MMR protein expression in neoplastic lesions. We show that the expression of the MMR protein corresponding to the germline mutation decreases along with increasing dysplasia in tumors. Similarly, methylation increases in LS adenomas and carcinomas together with dysplasia grade in comparison to normal colonic mucosa. A proportion of low-grade adenomas could already be classified CIMP positive, and the frequency of CIMP further increased in high-grade adenomas and carcinomas. Our results offer new insights into the molecular mechanisms through which DNA methylation can affect colorectal carcinogenesis in LS mutation carriers. Citation Format: Satu Valo, Sippy Kaur, Ari Ristimäki, Laura Renkonen-Sinisalo, Heikki Järvinen, Jukka-Pekka Mecklin, Minna Nyström, Päivi Peltomäki. DNA methylation changes in Lynch syndrome associated colorectal adenomas and carcinomas. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4766. doi:10.1158/1538-7445.AM2015-4766
Abstract IA15: Lymphangiogenesis and metastasis of postpartum breast cancer
Authors: Pepper J. Schedin, Virginia F. Borges
Journal: Cancer Research (2016)

Abstract Young women diagnosed with breast cancer have a 2-3 fold increased risk of metastatic disease if they are diagnosed within ten years of a completed pregnancy. We find a postpartum diagnosis to be a poor prognostic indicator independent of tumor stage and biologic subtype, leading to the investigation of whether postpartum breast involution is a mediator of metastasis. We show that human postpartum breast cancers have increased peritumor lymphatic vessel density that correlates with increased frequency of lymph node metastases. In addition, we show that breast cancer cells exposed to the involuting mammary microenvironment acquire pro-lymphangiogenic properties that contribute to peritumor lymphatic expansion, invasion, and distant metastases. This pro-lymphatic phenotype appears to be due to tumor cells hijacking developmentally-regulated programs normally restricted to the actively involuting mammary gland. Specifically, we find upregulation of lymphangiogenesis with weaning in the normal mammary glands of rodents and humans. Further, in rodent models of postpartum breast cancer, COX-2 inhibition limited to the involution window decreases normal mammary gland lymphangiogenesis, mammary tumor associated lymphangiogenesis, tumor cell invasion into lymphatics, and metastasis. Finally, we find that COX-2 inhibition also targets fibroblast activation and collagen production during mammary gland involution, raising the possibility that COX-2 orchestrates a whole tissue response that is supportive of tumor cell escape in the involuting gland. In summary, we show that physiologic COX-2 dependent fibroblast activation, collagen deposition, and lymphangiogenesis are coordinated in the postpartum mammary gland and suggest that tumors evolving in this unique microenvironment acquire enhanced pro-lymphangiogenic and pro-metastatic activities. These data provide further impetus for considering the use of COX-2 inhibitors in the treatment of postpartum breast cancer, and suggest novel prevention strategies targeted to recently pregnant women as well. Citation Format: Pepper J. Schedin, Virginia F. Borges. Lymphangiogenesis and metastasis of postpartum breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA15.
Unusual cytological features in multiple myeloma
Authors: Abbas Hashim Abdulsalam, Nafila Sabeeh, Bassam Francis Matti, Barbara J Bain
Journal: American Journal of Hematology (2016)

The cytological features of multiple myeloma are very variable. The cytoplasm may contain crystals or other inclusions, which may be spherical (Russell bodies), rod shaped, or granular. Distention of the endoplasmic reticulum by proteinaceous material is less common and in this patient was dramatic; the staining characteristics are likely to indicate a carbohydrate component and have been linked particularly to IgA myeloma.
Panic attacks in young adolescents
Authors: C Hayward, J D Killen, C B Taylor
Journal: American Journal of Psychiatry (1989)

The lifetime prevalence of interview-determined four-symptom panic attacks in 95 ninth graders was 11.6%. Those with panic attacks were significantly more depressed, were significantly more likely to have separated or divorced parents, and tended to be more likely to have tried cigarette smoking.
A NEW RICKETTSIAL DISEASE
Authors: P. W. C.
Journal: Annals of Internal Medicine (1948)

Editorial1 January 1948A NEW RICKETTSIAL DISEASEP. W. C.P. W. C.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-28-1-191 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptDuring the year 1946 many cases of an acute febrile infection of unusual character were observed in New York City.1, 2 Most of these cases occurred in a group of apartment houses in a small area in Regency Park (Borough of Queens) housing 543 families, although similar cases were subsequently reported from three other boroughs. The clinical picture was so characteristic and the etiological features so interesting that the disease merits some attention.The onset in most cases was abrupt with malaise, fever, usually chills and sweats, headache, pain in the orbits, and severe aching in the back and muscles...1 SUSSMAN LN: Kew Gardens' spotted fever, New York Med., 1946, ii, 27-28 (August 5). Google Scholar2 SHANKMAN B: Report on an outbreak of endemic febrile illness, not yet identified, occurring in New York City, New York State Jr. Med., 1946, xvi, 2156-2159. Google Scholar3 GREENBERGPELLITERIKLEINHUEBNER MOIFRJ: Rickettsialpox, Jr. Am. Med. Assoc., 1947, cxxxiii, 901-906. CrossrefGoogle Scholar4 HUEBNERSTAMPSARMSTRONG RJPC: Rickettsialpox—a newly recognized rickettsial disease. I. Isolation of the etiological agent, Pub. Health Rep., 1946, lxi, 1605-1614. CrossrefGoogle Scholar5 HUEBNERJELLISONPOMERANTZ RJWLC: Rickettsialpox—a newly recognized rickettsial disease. IV. Isolation of a rickettsia apparently identical with the causative agent of rickettsialpox from Allodermanyssus sanguineus, a rodent mite, Pub. Health Rep., 1946, lxi, 1677-1682. CrossrefGoogle Scholar6 HUEBNERJELLISONARMSTRONG RJWLC: Rickettsialpox—a newly discovered rickettsial disease. V. Recovery of Rickettsia akari from a house mouse (Mus musculus), Pub. Health Rep., 1947, lxii, 777-780. CrossrefGoogle Scholar7 BADGER LF: Rocky Mountain spotted fever and boutonneuse fever, a study of their immunological relationships, Pub. Health Rep., 1933, xlviii, 507-511. CrossrefGoogle Scholar8 DURAND P: La reaction de Weil-Félix dans le fièvre boutonneuse, Arch. Inst. Pasteur de Tunis, 1932, xx, 395-421. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 January 1948Volume 28, Issue 1Page: 191-194KeywordsFeversHeadachesInfectious diseasesLower back painMusclesMyalgiaRocky Mountain spotted feverSweat ePublished: 1 December 2008 Issue Published: 1 January 1948 PDF downloadLoading ...
The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation
Authors: Ke Zhao, Qifa Liu
Journal: Journal of Hematology & Oncology (2016)

Mesenchymal stromal cells (MSCs) are multipotent stem cells well known for repairing tissue, supporting hematopoiesis, and modulating immune and inflammation response. These outstanding properties make MSCs as an attractive candidate for cellular therapy in immune-based disorders, especially hematopoietic stem cell transplantation (HSCT). In this review, we outline the progress of MSCs in preventing and treating engraftment failure (EF), graft-versus-host disease (GVHD) following HSCT and critically discuss unsolved issues in clinical applications.
Case 13-1968
Authors: Claude E. Welch, Benjamin Castleman
Journal: New England Journal of Medicine (1968)

Presentation of CaseAn eighty-seven-year-old woman was admitted to the hospital because of vomiting and epigastric pain.Fifty-two years previously she underwent an appendectomy for chronic appendicitis; ventral suspension of a retroverted uterus was also performed. Thirty years before admission there was the onset of intermittent burning epigastric distress and vomiting associated with attacks of sharp right-upper-quadrant pain radiating to the interscapular region. The red-cell count was 3,500,000; the red cells appeared normal. An oral cholecystographic study was negative. A gastrointestinal series demonstrated marked curling of the esophagus and a hiatus hernia of moderate size; the duodenal cap was normal; . . .
An outbreak of food-borne botulism in Scotland, United Kingdom, November 2011
Authors: L  M Browning, H Prempeh, C Little, C Houston, K Grant, J  M Cowden, Collective on behalf of the United Kingdom Bot
Journal: Eurosurveillance (2011)

An investigation is currently underway to explain an outbreak of food-borne botulism in Scotland. Three children in the same family were confirmed as having botulism following consumption of a meal made with a jar of korma sauce. Residual sauce from the jar, the jar lid and a remnant of the meal, all tested positive for Clostridium botulinum type A toxin. The children are recovering, although two remain ventilated and in intensive care unit.