tbuckley/cabot-search huggingface dataset:
P2.05-007 Outcomes after Stereotactic Body Radiothrapy/Proton Beam Therapy or Wedge Resection for Stage I Non-Small-Cell Lung Cancer
Authors: Yasuhisa Ohde, Hideyuki Harada, Shoko Hayashi, Kiyomichi Mizuno, Yoshiyuki Yasuura, Reiko Shimizu, Hiroyuki Kayata, Hideaki Kojima, Shoji Takahashi, Mitsuhiro Isaka, Toshiaki Takahashi, Shigeyuki Murayama, Tetsuo Nishimura, Keita Mori
Journal: Journal of Thoracic Oncology (2017)
PUB018 Immunotherapy for KRAS Positive Lung Adenocarcinoma: Mesothelin and CA125 (MUC16) Are Cancer-Antigen Targets
Authors: Boris Hristov, Takashi Eguchi, Navin Chintala, Shaohua Lu, Matthew Bott, William Travis, David Jones, Prasad Adusumilli
Journal: Journal of Thoracic Oncology (2017)
Human Rabies — Puerto Rico, 2015
Authors: Ashley Styczynski, Cuc Tran, Emilio Dirlikov, María Ramos Zapata, Kyle Ryff, Brett Petersen, Anibal Cruz Sanchez, Marrielle Mayshack, Laura Castro Martinez, Rene Condori, James Ellison, Lillian Orciari, Pamela Yager, Rafael González Peña, Dario Sanabria, Julio Cádiz Velázquez, Dana Thomas, Brenda Rivera García
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

On December 1, 2015, the Puerto Rico Department of Health (PRDH) was notified by a local hospital of a suspected human rabies case. The previous evening, a Puerto Rican man aged 54 years arrived at the emergency department with fever, difficulty swallowing, hand paresthesia, cough, and chest tightness. The next morning the patient left against medical advice but returned to the emergency department in the afternoon with worsening symptoms. The patient's wife reported that he had been bitten by a mongoose during the first week of October, but had not sought care for the bite. While being transferred to the intensive care unit, the patient went into cardiac arrest and died. On December 3, rabies was confirmed from specimens collected during autopsy. PRDH conducted an initial rapid risk assessment, and five family members were started on rabies postexposure prophylaxis (PEP).
New “21st Century Cures” Legislation
Authors: Aaron S. Kesselheim, Jerry Avorn
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
P3.03-034 Comprehensive Immunophenotyping of the Blood and Pleural Fluid from Patients with Malignant Pleural Mesothelioma by Flow Cytometry
Authors: Tobias Peikert, Virginia Van Keulen, Svetlana Bornschlegl, Allen Dietz, Mike Gustafson
Journal: Journal of Thoracic Oncology (2017)
JCES01.24 Molecular Mechanism of Transformation from Adenocarcinoma to Small-Cell Lung Cancer after EGFR-TKI
Authors: Jiefei Han, Qiuyi Zhang, Binchao Wang, Qing Zhou, Lixu Yan, Zhou Zhang, Huajun Chen, Jian Su, Zhi Xie, Feiyu Niu, Yi Long Wu, Shannon Chuai, Jinji Yang, Zhong-Yi Dong
Journal: Journal of Thoracic Oncology (2017)
P20 Haemoptysis in patients with no evidence of lung malignancy on computed tomography-is flexible bronchoscopy necessary?
Authors: T Nisar, R Hastings, P Puthran
Journal: Thorax (2016)

<h3>Background</h3> Current NICE guidelines for lung cancer advocate referral to fast track clinic for unexplained haemoptysis in patients who are aged 40 and over. The current practice in our respiratory department and in most units across United Kingdom is to investigate this with a CXR, computed tomography (CT) thorax and flexible bronchoscopy regardless of the findings of the CT. <h3>Aim</h3> The aim of this study was to evaluate whether bronchoscopy adds any further value to the findings of highly sensitive CT scans in the current era. We particularly wanted to look at number of serious pathologies such as cancer detected by flexible bronchoscopy in these patients. <h3>Methods</h3> A retrospective analysis was conducted using our local bronchoscopy database which identified 148 flexible bronchoscopy episodes that fulfilled our inclusion criteria (all patients undergoing bronchoscopy for haemoptysis who had already undergone CT thorax which did not identify a cause for this). The cases were included irrespective of their smoking status and age and covered a period of 4 years between 2011 and 2015. <h3>Results</h3> A total of 148 flexible bronchoscopy episodes were reviewed. Female to male ratio was 1:3 and mean age was 59 years. 72% of patients were smokers. There was no case of lung cancer identified in this cohort of patients. No pathological finding was identified in 87% (129) of the cases. The common abnormal findings included nasal bleed-2%, haemangioma/telangiectasia-3%, purulent secretions-2%, dynamic airway collapse-1%, aberrant anatomy-1% and possible tumour-1%. The two cases of possible tumour were further evaluated with nasendoscopy and rigid bronchoscopy and no cancers were identified on biopsies. A single case of oral cancer was identified 1 year post bronchoscopy on follow up review of these cases. <h3>Conclusion</h3> In conclusion our study shows that in patients with haemoptysis with no relevant finding identified on CT and irrespective of their smoking status, flexible bronchoscopy does not reveal any significant serious pathogy. We would recommend that further studies are required to evaluate the investigative pathway for haemoptysis particularly if CT thorax does not identify a cause for haemoptysis.
Sheet-Like Remodeling of the Transverse Tubular System in Human Heart Failure Impairs Excitation-Contraction Coupling and Functional Recovery by Mechanical Unloading
Authors: Thomas Seidel, Sutip Navankasattusas, Azmi Ahmad, Nikolaos A. Diakos, Weining David Xu, Martin Tristani-Firouzi, Michael J. Bonios, Iosif Taleb, Dean Y. Li, Craig H. Selzman, Stavros G. Drakos, Frank B. Sachse
Journal: Circulation (2017)

Cardiac recovery in response to mechanical unloading by left ventricular assist devices (LVADs) has been demonstrated in subgroups of patients with chronic heart failure (HF). Hallmarks of HF are depletion and disorganization of the transverse tubular system (t-system) in cardiomyocytes. Here, we investigated remodeling of the t-system in human end-stage HF and its role in cardiac recovery.
P3.02c-003 TAX-TORC: The Novel Combination of Weekly Paclitaxel and the Dual mTORC1/2 Inhibitor AZD2014 for the Treatment of Squamous NSCLC
Authors: Matthew Krebs, James Spicer, Nicola Steele, Denis Talbot, Michael Brada, Richard Wilson, Robert Jones, Bristi Basu, Joanna Dawes, Mona Parmar, Beth Purchase, Alison Turner, Emma Hall, Holly Tovey, Udai Banerji, Timothy Yap
Journal: Journal of Thoracic Oncology (2017)
Very Long-Term Follow-up Results of Imatinib Mesylate Therapy in Chronic Phase Chronic Myeloid Leukemia After Failure of Interferon Alpha Therapy
Authors: Mona Lisa Alattar, Jorge E. Cortes, Susan O'Brien, Guillermo Garcia-Manero, Stefan Faderl, Farhad Ravandi, Elias Jabbour, Jianqin Shan, Hagop M. Kantarjian
Journal: Blood (2011)
International germ cell consensus classification: A prognostic factor-erased staging system for metastatic germ cell cancers
Authors: GM Mead, SP Stenning, P Cook, SD Fossa, A Horwich, SB Kaye, Rtd Oliver, Phm deMulder, R deWit, G Stoter, RJ Sylvester, DF Bajorin, GJ Bosl, M Mazumdar, CR Nichols, R Amato, G Pizzocaro, JP Droz, A Kramar, G Daugaard, H CortesFunes, L PazAres, JA Levi, BM Colls, VJ Harvey, C Coppin
Journal: Journal of Clinical Oncology (1997)

Purpose: Cisplatin-containing chemotherapy has dramatically improved the outlook for patients with metastatic germ cell tumors (GCT), and overall cure rates now exceed 80%. To make appropriate risk-based decisions about therapy and to facilitate collaborative trials, a simple prognostic factor-based staging classification is required. Materials: Collaborative groups from 10 countries provided clinical data on patients with metastatic GCT treated with cisplatin-containing chemotherapy. Multivariate analyses of prognostic factors for progression and survival were performed and models were validated on on independent data set. Results: Data were available on 5,202 patients with nonseminomatous GCT (NSGCT) and 660 patients with seminoma. Median follow-up time was 5 years, For NSGCT the following independent adverse factors were identified: mediastinal primary site; degree of elevation of alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactic dehydrogenase (LDH); and presence of nonpulmonary visceral metastases (NPVM), such as liver, bone, and brain. For seminoma, the predominant adverse feature was the presence of NPVM. integration of these factors produced the following groupings: good prognosis, comprising 60% of GCT with a 91% (89% to 93%) 5-year survival rate; intermediate prognosis, comprising 26% of GCT with a 79% (75% to 83%) 5-year survival rate; and poor prognosis, comprising 14% of GCT (all with NSGCT) with a 48% (42% to 54%) 5-year survival rate. Conclusion: An easily applicable, clinically based, prognostic classification for GCT has been agreed on between all the major clinical trial groups who are presently active worldwide. This should be used in clinical practice and in the design and reporting of clinical trials to aid international collaboration and understanding. (C) 1997 by American Society of Clinical Oncology.
P74 Non-invasive ventilation delivered on a standard respiratory unit compared to use in level 2 care setting: is there an ideal service delivery model?
Authors: A Jayadev, K Mcvinnie, I Moonsie
Journal: Thorax (2016)

<h3>Introduction</h3> BTS guidelines recommend Non-Invasive Ventilation (NIV) should take place in a clinical environment with enhanced monitoring, predicting 20% of all cases may need level 2 or 3 care.<sup>1</sup> However, current practice varies between and within NHS organisations. A management led service change within our Trust in 2013 enabled us to test the null hypothesis that there is no significant difference in mortality of COPD patients requiring NIV on an open respiratory-led unit (level 1 care), compared to a closed, anaesthetist led Level 2 setting (PCU, Progressive Care Unit). <h3>Methods</h3> An electronic search was performed to find patients on PCU whom received NIV between 1st January and 30th November 2014. Inclusion criteria were patients that had received NIV for COPD exacerbations solely. Data from the physician led respiratory unit between Jan–Nov 2011 was prospectively collected, and the two datasets compared. <h3>Results</h3> In the respiratory unit 75 patients were admitted for NIV of which 54 met the criteria for inclusion in the analysis. In the PCU group 110 patients were admitted between Jan–Nov 2014. of which 55 were included for analysis. Samples were matched in gender, with no significant difference between groups. The average age of patients treated in PCU was 69.8 years, and 74.4 years on the respiratory unit, which is statistically significant (Mann-Whitney U Test, p = 0.012). The mortality on PCU was 27.2% compared to 20.4% on the respiratory unit, which was not statistically significant. Mean pH on PCU was 7.33 compared to 7.24 on the respiratory Unit, which is statistically significant. Mean pCO<sub>2</sub> was 10.06 on PCU, and 10.5 on the respiratory unit, which is statistically significant. Average length of stay of ward patients was 15 days, compared to 11.4 days on PCU, which was not statistically significant. <h3>Conclusions</h3> NIV delivered on a physician-led respiratory unit was not inferior in mortality and length of stay compared with a closed, ITU-led service. Interestingly we found a significant difference in age of patients being treated with NIV, with significantly older patients receiving this on ward with no difference in overall mortality. <h3>Reference</h3> BTS Guidelines Management of AHRF 2016. http://www.brit-thoracic.org.uk
MA05.07 Identifying Comorbid Disease on Chest CT Scans in a Lung Cancer Screening-Eligible Cohort
Authors: Elizabeth Regan, Barry Make, Gregory Kinney, Matthew Budoff, Debra Dyer, Jeffrey Curtis, Russell Bowler, Meilan Han, Terri Beaty, John Hokanson, Elizabeth Kern, David Lynch, Edwin Van Beek, Edwin Silverman, James Crapo, James Finigan
Journal: Journal of Thoracic Oncology (2017)
Response Adapted Assignment of the Number of Chemotherapy Cycles for the Treatment of Patients with Diffuse Large B-Cell Lymphoma (DLBCL) Is Not Justified: Results of the RICOVER-60 Trial of the German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL).
Authors: Joerg Schubert, Marita Ziepert, Eva Lengfelder, Martin Mohren, Norma Peter, Marcel Reiser, Michael Clemens, Christina Nickenig, Maike deWit, Anthony Ho, Hartmut Eimermacher, Lorenz Truemper, Martin Hoffmann, Roland Mertelsmann, Bernd Metzner, Hans-Guenther Mergenthaler, Ruediger Liersch, Ulrich Duehrsen, Leopold Balleisen, Frank Hartmann, Viola Poeschel, Norbert Schmitz, Markus Loeffler, Michael Pfreundschuh
Journal: Blood (2007)
A Two Step Myeloablative Approach to Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) for Hematological Malignancies From HLA Partially-Matched (Haploidentical) Related Donors.
Authors: Dolores Grosso, Matthew Carabasi, Janet Brunner, Beth Colombe, Joanne Filicko-O'Hara, Eileen C Finnegan, Phyllis Flomenberg, Margaret Kasner, Bijoyesh Mookerjee, William O'Hara PharmD, Nyree Tedesco-Garafano, John L. Wagner, Maria Werner-Wasik, Neal Flomenberg
Journal: Blood (2009)
M13 The use of online health forums by chronic cough sufferers
Authors: A Sinha, AM Wilson, T Porter
Journal: Thorax (2016)

<h3>Introduction</h3> Chronic cough represents a significant health problem, affecting 10–20% of the population, for which effective medical support is often unavailable.<sup>1</sup> In such circumstances, and having exhausted medical options, patients may turn to online health forums to exchange support and seek information.<sup>2,3</sup> We aimed to determine how patients use health forums and in turn, how medical professionals might utilise them in clinical practice. <h3>Methods</h3> Three prominent open health forums were searched for threads related to cough, and screened against inclusion criteria adapted from the BTS guidance on cough<sup>1</sup>. Included threads were transcribed verbatim into QSR NVIVO, and subjected to qualitative thematic analysis. Findings were validated through the use of multiple reviewers. <h3>Results</h3> 96 threads were reviewed, with contributions from 223 forum users. Three predominant themes emerged: the impact of chronic cough, treatment suggestions, and supportive posts. Regarding the impact of chronic cough, users highlighted the physical and psychological sequelae from prolonged chough, and the limitations imposed upon daily activities. Users suggested both prescribed treatments and alternative remedies, with many offering potential diagnoses to query with medical professionals. Supportive posts involved various strategies designed to show sympathy and empathy with others. <h3>Conclusions</h3> Chronic cough patients use health forums to exchange information, advice and support. Health forums are a potential tool for clinicians wishing to access this population to provide medical care and promote patient education. We propose further research into these opportunities. <h3>References</h3> Morice AH, McGarvey L, Pavord I. Recommendations for the management of cough in adults. <i>Thorax</i> 2006;<b>61</b>(suppl 1):i1–i24. Nelson S, Hwang KO, Bernstam EV. Comparing clinician knowledge and online information regarding Alli (Orlistat). <i>Int J Med Inform</i> 2009;<b>78</b>(11):772–7. Poole R, Smith D, Simpson S. How patients contribute to an online psychoeducation forum for bipolar disorder: A virtual participant observation study. <i>JMIR Mental Health</i> 2015;<b>2</b>(3):e21.
Influence of GST Gene Polimorphisms in the Develovement of Liver Sinusoidal Obstructive Syndrome in Patients with Multiple Myeloma Undergoing Hematopoietic Stem Cell Transplantation.
Authors: Joaquin Martinez-Lopez, Guillermo Garcia-Efroom, Pilar Martinez-Sanchez, Ramon Garcia-Sanz, Juan Blade, Pedro Sanchez-Godoy, Felipe Arriba, Jose Maria Garcia-Larana, Maria Jose Terol, Enriqueta Albiza, Laura Montejano, Silvia Grande, Inmaculada Rapado, Belen Hernandez, Jesus San Miguel, Juan Jose Lahuerta
Journal: Blood (2006)
Lack of workforce planning raises safety concerns, says former health minister
Authors: Abi Rimmer
Journal: BMJ (2017)

The UK government’s lack of workforce planning to increase junior doctor numbers raises concerns about the safety of increased weekend working, a former Liberal Democrat health minister has said.

Norman Lamb said that, without a guaranteed increase in junior doctor numbers, increased weekend working could compromise services during the week. He said that the health secretary for England, Jeremy Hunt, had not fulfilled a pledge made last year to …
Pretreatment Serum Cytokines Predict Early Disease Relapse and a Poor Prognosis In Diffuse Large B-Cell Lymphoma (DLBCL) Patients
Authors: Stephen M. Ansell, Matthew J Maurer, Steven C Ziesmer, Susan L Slager, Thomas M Habermann, Brian Link, Thomas E Witzig, James Cerhan, Anne J. Novak
Journal: Blood (2010)
Risk of Multiple Sclerosis After a Clinically Isolated Syndrome
Authors: Jeffrey M. Gelfand
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Adjuvant Bortezomib and Dexamethasone Following Risk-Adapted Melphalan and Stem Cell Transplant in Systemic Light-Chain Amyloidosis (AL): A Phase II Study.
Authors: Heather Landau, Hani Hassoun, Adam D Cohen, Alexander Lesokhin, Christina Bello, Elizabeth Hoover, Elyn R Riedel, Jennifer Ciminiello, Emily McCullagh, Stephen D Nimer, Raymond Comenzo
Journal: Blood (2009)
P1.07-012 Efficacy of Immune Checkpoint Inhibitors in Large Cell Neuroendocrine Lung Cancer: Results from a French Retrospective Cohort
Authors: Matteo Giaj Levra, Julien Mazieres, Clarisse Audigier Valette, Olivier Molinier, David Planchard, Violaine Frappat, Leonie Ferrer, Anne Claire Toffart, Denis Moro-Sibilot
Journal: Journal of Thoracic Oncology (2017)
Prevention of Rheumatic Fever and Bacterial Endocarditis Through Control of Streptococcal Infections
Journal: Circulation (1960)

Rheumatic fever is a recurrent disease which frequently can be prevented. Infection with group A streptococci precipitates both initial and recurrent attacks; therefore, prevention of rheumatic fever and rheumatic heart disease depends upon the control of streptococcal infections. This may be accomplished, one by prevention of streptococcal infections in rheumatic subjects, and, two by early and adequate treatment of streptococcal infections in all individuals. Bacterial endocarditis may result from dental and other surgical procedures in patients with rheumatic or congenital heart disease. When such procedures are undertaken, these patients should be protected by administration of antibiotics in therapeutic doses .
Polycomb Group Member Rybp Is a Functional Tumor Suppressor Repressed By Mir-9 in MLL-Rearranged AML
Authors: Colles Price, Ping Chen, Shenglai Li, Zejuan Li, Yuanyuan Li, Xi Jiang, Hao Huang, Hengyou Weng, Bryan Ulrich, Stephen Arnovitz, Mary Beth Neilly, Jianjun Chen
Journal: Blood (2014)
P203 Acute oncology services and the chest physician
Authors: JA Benjamin, K Wingfield, C Garman
Journal: Thorax (2016)

<h3>Background</h3> At our trust (Popn 289400, x2 district general hospitals,) the Acute Oncology Service (AOS) began formally in June 2015. The team consists of 6 members, 3 consultants (1 session per week each ; x1 clinical lead at both sites and one clinical lead for metastatic spinal cord compression across both sites,) 2 clinical nurse specialists full time, 1 data coordinator full time. One of the 3 consultants is a chest physician (author.) In September 2014 a formal expression of need for AOS development was accepted and supported by Macmillan for a 3 year fixed term project. There was a well supported process of induction for the nurses and introduction of the service to the Health Board prior to becoming clinically available in September 2016. <h3>Outcomes</h3> <b>569 </b>patients have been seen since clinically active (Sept 2015) Median reduction in length of hospital stay (LOS) from <b>11 to 5 days </b>for patients with carcinoma of unknown primary (CUP) Median LOS since introduction of service is<b> 5 days </b>for all cancer diagnoses. This equates to a <b>1 day</b> reduction in LOS. Median LOS in preceding years 2011–2015 = 6 days The largest number of refrrals to the service has been for patients with lung cancer (21%) – see Table <h3>Conclusions/personnel reflections</h3> An effective AOS service improves quantatative outcomes(reduced LOS, efficient processing of CUP patients,) and enhances qualititative outcomes for patients (advocates for CUP patients,better communication*) The majority of cancers dealt with by the AOS service are lung cancer The outcomes above are almost exclusivley down to the AOS nurses but of all medical and surgical specialities,chest physicians (who deal with lung cancer) are ideally placed as clinical leads for this service due to their cancer experience and established links with radiology,pathology and palliative care (Author’s own opinion.) For present and future AOS services, this team would reccommend that an amenable/enthusisastic chest physician would be a valuable asset to the service * Patient feedback can be provided on request
Efficacy of Early Use of Rituximab In Steroid Refractory Severe Immune Thrombocytopenic Purpura In Adult Patients: Single Institution Experience From Saudi Arabia
Authors: Talha Badar, Syed Ziauddin A. Zaidi, Bassim Albeirouti, Arwa Abdelhameed, Abdul-Aziz Al-Humaidi
Journal: Blood (2010)