tbuckley/cabot-search huggingface dataset:
SOMATOSTATINA VS PLACEBO COMO PROFILAXIS DE PANCREATITIS AGUDA TRAS LA REALIZACIÓN DE UNA CPRE: RESULTADO DE ESTUDIO PROSPECTIVO, RANDOMIZADO, DOBLE CIEGO. ANÁLISIS INTERMEDIO
Authors: M Concepción, C Gómez-Oliva, C Guarner-Argente, A Juanes, X Diez, S Sáinz, A Farré, C Guarner
Journal: Endoscopy (2011)

Introducción: la pancreatitis aguda es la complicación más frecuente (5–8%) y potencialmente grave tras la realización de una CPRE. No existe ningún consenso acerca de la utilización sistemática de un fármaco como profilaxis de la misma. Se ha sugerido que la administración de somatostatina en bolus endovenoso podría tener un efecto beneficioso en su prevención. La administración de somatostatina en bolus consigue alcanzar rápidamente niveles con efectos terapéuticos efectivos sobre la disminución de la secreción pancreática, pero sólo dura unos minutos. En este estudio proponemos además del bolus, continuar con una administración continua de somatostatina tras la CPRE para mantener una disminución de la secreción pancreática durante el período de máximo riesgo de desarrollo de pancreatitis.
Three Phase Bone Imaging in a Patient With Fulminant Meningococcemia
Authors: D. GÓMEZ, V. IZQUIERDO, E. MACIAS, R. SIURANA, A. PUJOL, C. VIRGALA
Journal: Clinical Nuclear Medicine (1998)

Fulminant meningococcemia is the more serious form of presentation of meningococcial disease. It is characterized by the sudden onset of chills, petechiae, and shock with alterations in coagulation associated with ischemic lesions of any organ. The incidence of mortality is between 40-60%. Gangrene of the extremities is one of the complications and three phase bone scintigraphy may be useful for early diagnosis.
AB1179-HPR Associations between Occupational Balance and Immunology: Differences in Health Conditions, Employment Status Und Gender
Authors: M. Dür, G. Steiner, V. Fialka-Moser, A. Kautzky-Willer, M. Stoffer, B. Prodinger, C. Dejaco, J. Smolen, T. Stamm
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Occupational therapists are health professionals focusing on activities of daily living as a means, but also as an outcome of therapy. A balance of activities, the so-called "occupational balance", including other occupations than paid work e.g. self-care, household activities, voluntary work and caring for others, is one potential link between "occupations" and "health". There is growing evidence for the interrelations of neurological processes, immunological parameters and psychosocial factors. <h3>Objectives</h3> We aimed to compare the associations between occupational balance and immunological parameters of employed and non-employed people with rheumatoid arthritis and healthy controls. <h3>Methods</h3> We conducted a quantitative study in people in employable age with rheumatoid arthritis and healthy controls. Demographic data such as gender and employment status was collected. The Occupational Balance-Questionnaire and the SF-36 were used. Additionally, levels of immunological parameters, such as IL-6, IL-8, TNFα, INFα, RF, ACPA and CRP were measured. Descriptive statistics, Spearmen9s correlation coefficients and Mann-Whitney U tests were calculated. <h3>Results</h3> A total of 208 people (132 patients with rheumatoid arthritis and 76 healthy controls) participated. In employed healthy people few challenging activities were associated with low IL-6 values. No or rare feelings of overstress, satisfaction with the amount of rest and sleep and a "good" variety of activities were associated with low ACPA values. Healthy non-employed people having enough challenging activities had lower IL-8 and increased ACPA values. Compared to that, different correlations were identified in non-employed people with RA. For example, frequently perceived <i>impact of the health condition on activities</i>, less <i>ability to adapt activities</i> to changed living conditions and little or no <i>variety of activities</i> were associated with increased CRP values. The figure shows one example of the associations between CRP values and the <i>ability to adapt activities</i> in people with RA. <h3>Conclusions</h3> In the present study statistically significant differences of employed and non-employed people with RA and healthy controls were found. Hence, we suggest considering employment status, <i>impact of the health condition on activities</i>, <i>variety of activities</i> and <i>abilities to adapt activities</i> when targeting occupational balance in the treatment of people with RA. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3207
ENDOSCOPIA DIGESTIVA BAJA DE RUTINA EN LA DIVERTICULITIS AGUDA CONFIRMADA RADIOLOGICAMENTE POR TOMOGRAFIA COMPUTERIZADA. ¿EN QUIEN Y CUANDO ESTA INDICADA?
Authors: D Zaffalón, F Riu, MA Alvarez, JM Dedeu, M Pantaleón, F Bory, L Barranco, A Seoane
Journal: Endoscopy (2014)

Introducción: Las guías internacionales recomiendan la colonoscopia de rutina tras un episodio de diverticulitis aguda (DA) para descartar la presencia de neoplasia avanzada de colon (NAC). Sin embargo, tras la incorporación de la tomografía computarizada (TC) en el algoritmo diagnóstico, dicha recomendación está en entredicho.
Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression
Authors: M. L. Paine, J. R. Gibbins, J. M. Whitelock, R. L. O'Grady, R. F. Kefford
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Unregulated and Independent Expression of Collagenase and Transin Related to Tumor Progression Get access Michael L. Paine, Michael L. Paine Department of Pathology, University of SydneyAustralia and Department of Medical Oncology, University of SydneyWestmead Center, Westmead, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar John R. Gibbins, John R. Gibbins Department of Pathology, University of Sydney John R. Gibbins, Ph.D., Department of Pathology, University of Sydney, Sydney NSW, 2006, Australia. Search for other works by this author on: Oxford Academic PubMed Google Scholar John M. Whitelock, John M. Whitelock Division of Biomolecular Engineering, Commonwealth Scientific and Industrial Research Organization (CSIRO)North Ryde, Australia Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert L. O'Grady, Robert L. O'Grady Department of Pathology and Immunology, University of TechnologySydney Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard F. Kefford Richard F. Kefford Department of Medical Oncology, University of SydneyWestmead Center * See “Notes” section following “References.” Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 17, 1 September 1993, Pages 1425–1427, https://doi.org/10.1093/jnci/85.17.1425 Published: 01 September 1993 Article history Received: 11 March 1993 Revision received: 14 June 1993 Accepted: 22 June 1993 Published: 01 September 1993
Acute Appendicitis during Menstruation
Authors: Alexander A. Levi
Journal: New England Journal of Medicine (1952)

IT IS my impression, derived from over twenty years of experience in surgery, that acute appendicitis rarely occurs during menstruation. The records of three hospitals in the Boston area were studied in an attempt to verify this idea, and the cases of 725 women upon whom appendectomy only had been performed were reviewed. The pathologist reported acute appendicitis in 265 of these cases. In this group, operations were performed on 242 patients between the ages of eleven and fifty years, the age group taken as the possible limit of years during which menstruation might occur. The fact of the absence . . .
PML in a Patient Treated with Fumaric Acid
Authors: Ummehan Ermis, Joachim Weis, Jörg B. Schulz
Journal: New England Journal of Medicine (2013)

Two cases of progressive multifocal leukoencephalopathy (PML) are reported in patients with psoriasis who were treated with fumarates, one with Fumaderm and the other with a compound containing dimethyl fumarate. The manufacturer of Fumaderm comments on the reports.
Abstract 770: The orphan receptor Nur77 overexpression and translocation induced by PCH4 may inhibit malignant brain tumor growth and induce cell apoptosis
Authors: Chang Li-Fu, Po-Cheng Lin, Tzyy-Wen Chiou, Horng-Jyh Harn
Journal: Cancer Research (2010)

Abstract N-butylidenephthalide(BP), a nature compound from Angelica sinensis, has the antitumor effect in vitro and in vivo. Further, we modified the chemical structure of BP for increasing the antitumor effect and one derivative is (Z)-N-(2-(dimethylamino)ethyl)-2-(3-((3-oxoisobenzofuran-1(3H)-ylidene)methyl)phenoxy)acetamide, PCH4, has 4 times tumor inhibition on human glioblastoma multiform DBTRG-05MG cells. The IC50 of PCH4 on DBTRG-05MG cells is 50 μg/ml. The PCH4 induced apoptosis was related to Nur77 expression and translocation from nucleus to cytosol. Furthermore, the inhibition of PCH4-induced Nur77 expression by Nur77 siRNA can reduce the PCH4-induced apoptosis. In addition, The PCH4-induced apoptosis was associated with JNK pathway. The JNK inhibitor, SP600125, inhibited the Nur77 mRNA expression and reduced the PCH4-induced apoptosis. In conclusion, It suggesting us that the PCH4, the derivatives of BP, induce the Nur77-mediated apoptosis through the JNK pathway and this mechanism different from BP may increase the antitumor effect on GBM cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 770.
P0989 : A combination of elastometry and blood markers improves the non-invasive staging of liver fibrosis in NAFLD
Authors: J. Boursier, J. Vergniol, A. Guillet, J.-B. Hiriart, B. Le Bail, S. Michalak, S. Bertrais, F. Chermak, F. Oberti, J. Foucher, I. Fouchard-Hubert, M. Charbonnier, M.-C. Rousselet, P. Cales, V. de Ledinghen
Journal: Journal of Hepatology (2015)
PTH-013 Routine Coagulation Profile Prior To Ercp – An Unnecessary Investigation?
Authors: L Onos, A Wyman
Journal: Gut (2014)

<h3>Introduction</h3> From the first reported endoscopic retrograde cholangiopancreatography (ERCP) in 1968 to the invention of endoscopic sphincterectomy in 1974, ERCP has evolved to an almost entirely therapeutic procedure. It is appreciated that approximately 54,000 patients undergo ERCP each year.<sup>1</sup> The 2008 British guidelines include routine pre-procedural coagulation screen within 3 days prior to ERCP.<sup>2</sup> However, the American Society for Gastrointestinal Endoscopy guidelines state that the prothrombin time, International Normalised Ratio (INR), and activated partial thromboplastin time in patients without clinical evidence of bleeding disorder or coagulopathy do not predict or correlate with either intraoperative or postoperative haemorrhage.<sup>3</sup> <h3>Methods</h3> A 12-month retrospective study of 440 patients undergoing ERCP in a single UK tertiary institution was undertaken. The correlation between the presence of a biochemical cholestatic picture and the INR was assessed. <h3>Results</h3> The blood results of 440 patients were reviewed using the ICE (Integrated Clinical System). The median age was 67-years. Of the 440 patients, 310 had deranged LFTs, 86 had a normal liver profile, and 44 had no LFTs taken prior to ERCP. Of those with deranged LFTs, 2% had only a raised bilirubin, less than 6% had either only raised transaminases or both raised transaminases and bilirubin, 12% had only both raised alkaline phosphatase (ALP) and bilirubin, 15% had both raised ALP and transaminases, 22% had only raised ALP, and 43% had a trio of raised bilirubin, ALP, and transaminases. Only 11 patients had no coagulation profile taken before the procedure. Out of the remaining 429 patients, 15 were on warfarin, 2 had haemophilia, 1 was thrombocytopenic, and 1 had von Willebrand’s disease. However, out of 440 patients only 2 had an INR greater than 1.5, 1 of them being on warfarin. <h3>Conclusion</h3> These results suggest that routine measurement of coagulation profile is unnecessary. This would reduce time delays, decrease costs and avoid further tests in patients. We suggest that the current pre-ERCP investigation guidelines be reviewed.<sup>4</sup> <h3>References</h3> The future of service and training in ERCP in UK-J. R. B. GREEN and The UK ERCP Stakeholders working party- August 2007-British Society of Gastroenterology J Williams, J Green, I Beckingham, R Parks, D Martin, M Lombard-Guidelines on the management of common bile duct stones- Gut 2008;57:1004–1021. doi:10.1136/gut.2007.121657 Position statement on routine laboratory testing before endoscopic procedures-http://www.asge.org Baillie John, Pier‐Alberto Testoni. Are we meeting the standards set for ERCP? Gut. 2007 June; 56(6):744–746. doi: 10.1136/gut.2006.113456 <h3>Disclosure of Interest</h3> None Declared.
Abstract P3-04-01: Protein pathway activation mapping of the I-SPY 1 biopsy specimens identifies new network focused drug targets for patients with triple negative tumors
Authors: JD Wulfkuhle, D Wolf, RI Gallagher, C Yau, V Calvert, V Espina, J Illi, Q Wu, M Boe, Y Yan, LA Liotta, Veer L van't, L Esserman, EF Petricoin
Journal: Cancer Research (2012)

Abstract Background: Identification of new therapies and predictive biomarkers is needed for patients with triple negative (TN) breast cancer. Elucidating pathway activation in cancer is critical as these proteins represent targets for many of the new molecular therapeutics and companion diagnostic markers. The I-SPY TRIAL (CALGB 150007/150012, ACRIN 6657) is a trial of neoadjuvant anthracycline- and taxane-based chemotherapy that provides longitudinal biopsy specimens and molecular and clinical/pathological characterization. Methods: Tumor epithelium was procured by Laser Capture Microdissection from 149 pretreatment frozen biopsy specimens (T1) and 102 frozen biopsy specimens collected 1–4 days after first chemotherapy treatment (T2). Reverse Phase Protein Microarray was used to measure the activation of 39 and 100 signaling proteins in the T1 and T2 biopsies, respectively, including drug targets for Phase I-III and FDA cleared therapeutics. Associations between pathway activation and response to chemotherapy (RCB 0/1 vs. 2/3) and relapse-free survival (RFS) were evaluated for the triple-negative (TN) patient population at each time point and for changes between T1 and T2. Significance thresholds for response and RFS were as follows: Wilcoxon rank sum test p &amp;lt; 0.05; Cox proportional hazard model, likelihood ratio p &amp;lt; 0.05. Results: We focused our analysis on protein changes in patients who had poor clinical outcomes (Table 1) We observed systemic activation of receptor tyrosine kinases such as MET and ALK in the T2 biopsies from patients that recurred, and VEGFR activation was seen in the T1 relapsed tumors. Activation in the AURORA-PLK1 cell cycle signaling network was seen with increased activation in the T2 biopsy from patients who did not respond to therapy and had poor RFS. Dynamic changes in ERK activation were revealed with decreased ERK activation between T1 and T2 time points associated with recurrence. Conclusions: Our analysis has revealed activation and increased expression of proteins involved in proliferation (Ki67), DNA repair (phosphorylated p53) and protein kinases in patients with TN disease who had poor clinical response. These events, if validated, point to potential treatment options that could be considered for non-responding TN breast cancer patients. VEGFR, ALK and MET, have FDA cleared therapeutics that could be rationally proposed for rapid clinical investigation, and there are numerous investigational agents that target AURORA and PLK1 in the clinic. Further validation is required to explore the significance of these ongoing findings with the hope that the analysis could lead to molecularly rationalized therapies for patients with TN tumors. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-04-01.
AB0357 Pregnancy outcomes of rheumatic patients with pre/peri gestational leflunomide exposure
Authors: O. Karadag, L. Kilic, A. A. Erbil, N. Yılmaz, A. Akdogan, U. Kalyoncu, S. A. Bilgen, S. Kiraz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Leflunomide is a frequently used disease modifying drug in rheumatoid arthritis, psoriatic arthritis, vasculitis etc. Findings from animal studies have suggested that leflunomide may be a human teratogen and a wash out protocol is required for patients before planning pregnancy. Data about pregnancy in patients with leflunomide exposure is limited with case reports and case series. <h3>Objectives</h3> This study is aimed to evaluate the outcomes of pregnancies in patients with leflunomide exposure. <h3>Methods</h3> Hospital files between years of 2004-2012 were used for selecting patients who used leflunomide before or during pregnancy. In addition to demographic and clinical characteristics of patients, a study form consist of -drugs usedbefore pregnancy, elimination application, duration of pregnancy, drug use and pregnancy outcomes- is filled. Totally 33 patients (female /male: 24/9) were included into the study. <h3>Results</h3> In 12 of 33 patients (36.4%) no pregnancy occurred during more than 1 year follow up. Pregnancy took place in 16 (66.7%) of female and 5 (55.6%) of male patients' wives while in others no pregnancy occurred Bloods levels of leflunomide were examined in 19 of 21 pregnancies. Leflunomide washout protocol with cholestyramine was applied in 15 patients. In 13 of female patients leflunomide was interrupted before pregnancy but in 3 patients it was stopped after detection of pregnancy. Results and the complications of pregnancies were shown in <b>Table 1</b>. Anti-Tumor necrosis factor (Anti-TNF) usage was positive in 4 of them – one of them had used during pregnancy. Majormalformations were not detected in any infants. Premature membrane rupture was observed in wife of a male patient. <h3>Conclusions</h3> Observation of none pregnancy in more than one third of patients during &gt;1 year follow up, might reflect that rheumatic patients on leflunomide treatment had an increased reproductive problems. Wash out protocol and assessing blood drug level are used in most of patients before planning pregnancy. Althoughwe experienced no major malformations, the rate of complications such as premature rupture of membrane and low birth weight were higher. To give rise to more precise data, methods of contraception should be advised in patients receiving leflunomide. <h3>Disclosure of Interest</h3> None Declared
Abstract 2143: Smg-GDS regulates cellular proliferation in squamous cell carcinomas of the head and neck
Authors: Jonathan M. Bock, Kay Wrege, Nikki Johnston, Alexander C. Mackinnon, Carol L. Williams
Journal: Cancer Research (2012)

Abstract Squamous cell carcinoma of the head and neck (SCCHN) is a major worldwide source of morbidity and mortality, with over 26,000 estimated new cases and 6,000 deaths from pharyngeal and laryngeal cancer in 2011 in the the United States alone. SCCHN is an aggressive disease which is characterized by local invasion and lymphatic and distant metastasis. Ras and Rho family GTPases are known to regulate tumor cell proliferation in numerous human cancers including SCCHN. SmgGDS, an unusual guanine nucleotide exchange factor, has previously been shown in other systems to activate these small GTPases and directly regulate cellular proliferation through control of small GTPase prenylation and cellular localization. Little is known about the role of SmgGDS in the progression of SCCHN. These studies were begun to characterize the expression of SmgGDS in SCCHN and assess the role that SmgGDS plays in SCCHN proliferation. SCCHN tumor tissue microarray analysis demonstrated increased SmgGDS expression in tumor tissue from various head and neck sites compared to normal tissues, with evidence for higher SmgGDS expression at the pushing tumor boarders in invasive cancers. Significantly increased amounts of SmgGDS protein and RNA expression were also noted in head and neck tumor cell lines compared to cultured normal head and neck tissue cell lines. To assess the function of Smg-GDS expression in SCCHN, UM-SCC-1 cells were transfected with siRNA directed toward the 60.7 and 55.8 kD SmgGDS isoforms, with significant decreases in S-phase distribution for all treatments. Blocking both 60.7 and 55.8 kD SmgGDS isoforms with siRNA induced an 89% decrease in S-phase distribution as determined by Click-iT Edu cell cycle proliferation assay. These studies confirm an active role for SmgGDS protein function in the promotion of cancer cell proliferation in SCCHN, and provide the basis for further investigations into the role of small GTPases in head and neck neoplasia. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2143. doi:1538-7445.AM2012-2143
Could the inhalation of cadmium and other metals in addition to textile dust inhalation account for the observed increased risk of rheumatoid arthritis in textile workers?
Authors: Dan Murphy, Aishwarya Mathew, Benjamin James, David Hutchinson
Journal: Annals of the Rheumatic Diseases (2016)

We read the report of Too et al 1 with interest. We support the hypothesis of gene–environment interaction triggering an autoimmune response to citrullinated proteins in lung tissue, and feel this study strengthens the concept of inhalation of workplace dust or fumes stimulating rheumatoid arthritis (RA) development.

It has been hypothesised that cadmium inhalation within dust or fumes may trigger RA.2 This hypothesis noted that patients with RA are significantly more likely to work in specific occupations associated with increased cadmium exposure as a result of inhalation of various dusts or fumes. Textile manufacture may well be added to this as an …
Detection of Pseudoaneurysm After Heminephrectomy With Tc-99m Labeled Red Blood Cell Bleeding Study
Authors: DONALD W. TREPASHKO, PRATIBA K. SANSI, SREENIVISA GUDDETI, BRADLEY G. LANGER
Journal: Clinical Nuclear Medicine (1997)

A 5-year-old girl with a history of Wilm's tumor of the upper pole of the right kidney underwent upper pole heminephrectomy. She initially did well. Ten days postoperatively, she experienced an episode of hematuria and clot passage with a significant drop in hemoglobin and hematocrit, requiring one unit of packed red blood cells (RBCs). Work up for a renal source of the bleed included ultrasound, which failed to demonstrate the etiology of bleeding. The tagged RBC scan demonstrated a focal area of activity in the superior aspect of the resected kidney consistent with a pseudoaneurysm. This was confirmed on angiography. The patient subsequently underwent embolization of the pseudoaneurysm without complication.
1309 HISTOLOGICAL SEVERITY OF NAFLD AND DIETARY INTAKE PATTERN IN OBESE PATIENTS UNDERGOING BARIATRIC SURGERY - PRELIMINARY RESULTS
Authors: I. Mendes de Almeida, E. Ferreira, S. Policarpo, P. Almeida Nunes, M. Machado, A. Costa, F. Carepa, J. Coutinho, H. Cortez-Pinto
Journal: Journal of Hepatology (2012)
Letter to the editor: Trends in human leptospirosis in Denmark, 1980 to 2012
Authors: M Goris, R Hartskeerl
Journal: Eurosurveillance (2015)

Preview this article: Letter to the editor: Trends in human leptospirosis in Denmark, 1980 to 2012, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/20/9/art21053-en-1.gif