tbuckley/cabot-search huggingface dataset:
PWE-429 Development of a gastroenterology handbook for junior doctors
Authors: E Sweeney, J Clough, P Smith
Journal: Gut (2015)

<h3>Introduction</h3> Every 4–6 months new junior doctors rotate through Gastroenterology departments across the UK. The General Medical Council recommends that induction and support mechanisms are in place so that junior doctors are able to deliver “safe, effective and efficient care to patients as soon as they start a new job.”<sup>1</sup>We developed a Gastroenterology handbook containing relevant and important clinical information to be used nationally as part of the induction process for junior doctors. <h3>Method</h3> In order to establish the need for such a resource we surveyed consultants and junior doctors from across the UK, and solicited advice on its content. We developed a first draft and sought the endorsement of the Trainees Section of the British Society of Gastroenterology (BSG), who agreed to support the production of the handbook and verify its content. The content included resources for management of acute Gastroenterology conditions based on up-to-date consensus guidelines, and sections on procedural skills. Feedback from a focus group of junior doctors attending the BSG Gastroenterology Taster Conference was extremely positive. A second draft has been piloted on six junior doctors in the Gastroenterology department at Aintree University Hospital Liverpool. <h3>Results</h3> Prior to developing the handbook, 22 Gastroenterology consultants from 16 NHS trusts were surveyed as to the perceived ‘need’ for such a resource as well as suggested content. 73% of departments had an induction meeting for new junior doctors, with 32% having pre-existing written induction material. A significant proportion (18%) had no induction for junior doctors. 68% of consultants felt that a national Gastroenterology handbook would improve the induction process at their trust. 12 junior doctors (FY1-CT2 level) in several trusts were also surveyed. 41% had no induction on starting their Gastroenterology rotation, and 75% were apprehensive about managing acutely unwell patients. All of the trainees believed that the Gastroenterology handbook would be a valuable resource. Survey responses suggested that the most important clinical scenarios to include were acute GI bleed, decompensated liver disease, and acute colitis. <h3>Conclusion</h3> A standardised national clinical induction handbook for junior Doctors working in Gastroenterology does not already exist, and there is considerable appetite amongst junior doctors and Gastroenterology consultants for such a resource. We created a handbook with the aim of easing the transition of junior doctors joining Gastroenterology departments, and improving patient care. We intend to introduce the handbook nationally for the intake of doctors in August 2015. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> GMC guidance, Induction and Mentoring; http://www.gmc-uk.org/guidance/ethical_guidance/11825.asp; accessed on 25.02.2015
Acute Emotional Stress and the Heart
Authors: Janet M. Torpy
Journal: JAMA (2007)

Acute Emotional Stress and the Heart Experiencing emotional or physical stress causes an increase in heart rate, elevation of blood pressure, and release of stress hormones.All these result in a greater workload for the heart, which can be dangerous.Stress can cause a heart attack, sudden cardiac death, heart failure, or arrhythmias (abnormal heart rhythms) in persons who may not even know they have heart disease.Individuals with congestive heart failure, coronary heart disease, known arrhythmias, or other heart or blood vessel diseases should avoid emotional stress whenever possible and learn to manage the effects of stress.Excessive physical exertion and emotional stress may cause problems in both men and women, but women seem to be particularly susceptible to developing heart problems in the face of emotional stress.Ask your doctor about any limitations on physical activity or vigorous exercise if you have heart disease.The July 18, 2007, issue of JAMA includes an article about acute emotional stress and its effects on the heart.
Anovulation
Authors: Diana Hamilton-Fairley, Alison Taylor
Journal: BMJ (2003)

<h3>Background</h3> Youth gymnastic athletes have high risk for knee, ankle, spine and shoulder injury. Specific preventive programs could reduce injury incidence and sports time loss, which may reflect positively in an athlete9s performance. <h3>Objective</h3> Compare injury incidence rate before and after the implementation of a tailored preventive intervention in youth gymnastic athletes. <h3>Design</h3> Prospective study. <h3>Setting</h3> All athletes were followed-up over a three-year period at Minas Tenis Clube. The tailored preventive intervention was implemented only in the third year. <h3>Patients (or Participants)</h3> 82 female and male gymnastic athletes participated in this study; the mean for age was 10.59±2.69 years; body mass, 33.36 ±12.86 kg; and height 136.99±15.98 cm. <h3>Interventions (or Assessment of Risk Factors)</h3> After a preseason assessment a tailored preventive intervention was developed, including: 1) thoracic spine, shoulder, hip and ankle mobility; 2) core and scapular stabilization; 3) hip external rotation, eccentric lower limb and intrinsic foot muscle strengthening; 4) breathing exercises associated with core muscles. This preventive program was applied four times a week for 20 min supervised by the coaches and two times a week was executed by the sports physiotherapist. <h3>Main Outcome Measurements</h3> Injury incidence rate by 1000 hours of exposure and days of time loss were calculated each year. <h3>Results</h3> during the first two years without preventive intervention the injury incidence was 8.8 and 8 injuries/1000 h, respectively. The third year with preventive intervention had an incidence rate of 3.8 injury/1000 h. The average time loss of the two years was 902 days and in the third year was 345 days. T-test revealed statistical difference pre and post intervention (p&lt;0,02). <h3>Conclusions</h3> This study has shown that a tailored preventive intervention was effective to reduce the injury incidence rate in youth gymnastic athletes.
Unrelated Cord Blood Does Not Increase An Overall Risk Of Invasive Fungal Infections Compared To Unrelated Bone Marrow: A Single Center Retrospective Analysis For 749 Recipients
Authors: Yuki Asano-Mori, Hideki Araoka, Muneyoshi Kimura, Daisuke Kaji, Hikari Ota, Kazuya Ishiwata, Masanori Tsuji, Hisashi Yamamoto, Go Yamamoto, Naoyuki Uchida, Koji Izutsu, Akiko Yoneyama, Shigeyoshi Makino, Shuichi Taniguchi
Journal: Blood (2013)
Case 24-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Gary R. Epler, Eugene J. Mark
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 65-year-old woman was admitted to the hospital because of a cough and bilateral pulmonary infiltrates.She was well until six years earlier, when she began to have scalp pain and tenderness that radiated to the jaw and gums. A physician prescribed an antibiotic, and her symptoms subsided after one month. One month later diplopia developed abruptly, and she was admitted to the hospital, where examination showed a right internuclear ophthalmoplegia, with mild nystagmus of the left eye on leftward and upward gaze, and slight unsteadiness of gait. There was questionable tenderness over the left temporal artery, . . .
Dimethyl fumarate restores apoptosis sensitivity and inhibits tumor growth and metastasis in CTCL by targeting NF-κB
Authors: Jan P. Nicolay, Karin Müller-Decker, Anne Schroeder, Markus Brechmann, Markus Möbs, Cyrill Géraud, Chalid Assaf, Sergij Goerdt, Peter H. Krammer, Karsten Gülow
Journal: Blood (2016)
Dimension in defining tumor response.
Authors: R Chappell, S S Miranpuri, M P Mehta
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.3.1234 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9508213 Dimension in defining tumor response. R ChappellxR ChappellSearch for articles by this author , S S MiranpurixS S MiranpuriSearch for articles by this author , M P MehtaxM P MehtaSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.3.1234 PDF "Dimension in defining tumor response.." Journal of Clinical Oncology, 16(3), p. 1234© 1998 by American Society of Clinical Oncology
The need to harmonise management of HIV exposure in Europe
Authors: R Tubiana
Journal: Eurosurveillance (2004)

Harmonised European recommendations for the management of HIV exposure have been needed for some time. Important and impressive work has been achieved by two groups of experts from a total of 14 countries, and their conclusions and recommendations are reported in the two papers from Jesús Almeda et al and Vincenzo Puro et al [1,2]. Two characteristic settings are specified, although the difference between each is debatable if the issue is to avoid or prevent an established infection after exposure to HIV (or, indeed, HCV or HBV). As the authors point out, post-exposure prophylaxis (PEP) is the standard of care for healthcare workers (HCW) in almost all countries including the United States, but not for the management of sexual, injecting drug use or other non-occupational exposures to HIV.
THU0566 Certain Autoimmune Diseases are Associated with Distinctive Karyotypes and Outcome in Patients with Myelodysplastic Syndrome
Authors: S.J. Lee, S.H. Joo, E.B. Lee, Y.W. Song, S.-S. Yoon, J.K. Park
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Up to 10% of patients with myelodysplastic syndrome (MDS) develop features of autoimmune diseases (AD). However, the factors associated with AD and their effects on MDS outcome have not been fully elucidated <h3>Objectives</h3> This study is aimed to investigate whether AD is associated with specific karyotype and outcome in patients with MDS. <h3>Methods</h3> A total of 67 MDS patients with AD and 201 age-, sex matched MDS patients without AD (at 1:3 ratio), who received medical care at Seoul National University Hospital from January 2000 through July 2014, were enrolled in this study. Clinical features and outcomes of MDS patients with vs. without AD were examined. <h3>Results</h3> The mean age (±SD) at MDS diagnosis was 54±17.1 years and 55% were female. Among MDS patients with AD, skin disease (Sweet9s syndrome and panniculitis) was most prevalent with 26 (39%) of 67 observed AD cases, followed by 9 (13%) Behcet9s disease, 8 (12%) vasculitis, 9 (13%) rheumatoid arthritis, 4 (6%) myositis, 3 (5%) spondyloarthropathy and 2 (3%) systemic lupus erythematous. 5q deletion was more frequent in MDS with AD as compared to those without AD (23% vs. 11%, p=0.023) and was associated with a 6.08 fold-increased risk for skin disease (95% confidence intervals (CI): 2.41-15.36, p&lt;0.001). The trisomy 8 was significantly more frequent in Behcet9s disease (OR 6.47, 95% CI: 1.4-30.6, p=0.024). Strikingly, the presence of skin disease was associated with a 3.29 fold increase in mortality (p=0.003 by Cox regression analysis). <h3>Conclusions</h3> Certain ADs are associated with distinctive MDS karyotypes and worse outcomes. Thus, the presence of AD features should be considered for evaluation of prognosis and so the treatment intensity. <h3>Disclosure of Interest</h3> None declared
&lt;emph type="ital"&gt;Drug Store&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2008)

Behold the corner drugstore! An anachronism, perhaps a fantasy, it represents the vestiges of a simpler time. American painter Edward Hopper (1882-1967) captured his vision of the fleeting past blending into the reality of 1927 in Drug Store (cover).
CSF neurochemistry in depressed, manic, and schizophrenic patients compared with that of normal controls
Authors: R H Gerner, L Fairbanks, G M Anderson, J G Young, M Scheinin, M Linnoila, T A Hare, B A Shaywitz, D J Cohen
Journal: American Journal of Psychiatry (1984)

A total of 114 subjects (41 depressed, 20 schizophrenic, 15 manic, and 38 normal controls) underwent lumbar puncture and their CSF was analyzed for levels of tyrosine, tryptophan, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), 3-methoxy-4-hydroxyphenylglycol (MHPG), choline, gamma-aminobutyric acid (GABA), and calcium. Results showed that depressed patients, particularly those over 40 years of age, had lower levels of GABA than did controls, and that their level of HVA increased with age, while controls' decreased. Schizophrenic subjects tended to have higher levels of 5-HIAA and manic subjects tended to have higher levels of HVA and MHPG. Age-associated changes were found in HVA, 5-HIAA, MHPG, GABA, and choline concentrations.
Case 13-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, Bruce D. Weintraub, Robert E. Scully
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 53-year-old man was admitted to the hospital because of a pulmonary infiltrate.Between six and 16 years of age he had had severe bronchial asthma. He began to smoke cigarettes at the age of 16 years and consumed two packages daily thereafter. A chronic nonproductive cough developed. Four years before admission mild hypertension was found; no treatment was prescribed. Two years before entry an x-ray film of the chest was normal. One year later he began to cough up thick, greenish-yellow sputum. Two weeks before admission he noticed tenderness of the left nipple, which was followed . . .
Intensive care unit surveillance of influenza infection in France: the 2009/10 pandemic and the three subsequent seasons
Authors: Isabelle Bonmarin, Emmanuel Belchior, Jean Bergounioux, Christian Brun-Buisson, Bruno Mégarbane, Jean Loup Chappert, Bruno Hubert, Yann Le Strat, Daniel Lévy-Bruhl
Journal: Eurosurveillance (2015)

During the 2009/10 pandemic, a national surveillance system for severe influenza cases was set up in France. We present results from the system's first four years. All severe influenza cases admitted to intensive care units (ICU) were reported to the Institut de Veille Sanitaire using a standardised form: data on demographics, immunisation and virological status, risk factors, severity (e.g. acute respiratory distress syndrome (ARDS) onset, mechanical ventilation, extracorporeal life support) and outcome. Multivariate analysis was performed to identify factors associated with ARDS and death. The number of confirmed influenza cases varied from 1,210 in 2009/10 to 321 in 2011/12. Most ICU patients were infected with A(H1N1)pdm09, except during the 2011/12 winter season when A(H3N2)-related infections predominated. Patients' characteristics varied according to the predominant strain. Based on multivariate analysis, risk factors associated with death were age ≥ 65 years, patients with any of the usual recommended indications for vaccination and clinical severity. ARDS occurred more frequently in patients who were middle-aged (36-55 years), pregnant, obese, or infected with A(H1N1)pdm09. Female sex and influenza vaccination were protective. These data confirm the persistent virulence of A(H1N1)pdm09 after the pandemic and the heterogeneity of influenza seasons, and reinforce the need for surveillance of severe influenza cases.
The Treatment of Infantile Paralysis in the Acute Stage
Authors: J PROCHAZKA, V ADAMOVA-PANKOVA
Journal: JAMA (1942)

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Evaluation of a regional Indian alcohol program
Authors: L G Wilson, J H Shore
Journal: American Journal of Psychiatry (1975)

The authors analyzed follow-up data collected by an Indian counselor and a psychiatrist on 83 American Indian alcoholic men. Follow-up status was judged by an interdisciplinary panel according to a six-step rating scale. The 44 percent improvement rate compares favorably with other treatment programs, especially in view of the selection process, which favored difficult patients. The authors suggest that the interdisciplinary rating panel is an approach that can prevent erroneous judgments of the drinking status of American Indians.
QOL-16HEALTH-RELATED QUALITY OF LIFE (HRQoL) IN A PHASE II TRIAL OF HYPOFRACTIONATED INTENSITY-MODULATED RADIATION THERAPY (HYPO-IMRT) WITH TEMOZOLOMIDE (TMZ) AND BEVACIZUMAB (BEV) FOR PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA MULTIFORME (GBM)
Authors: Alexander Mohler, Douglas Ney, Laurie Gaspar, Denise Damek, Brian Kavanagh, Krishna Reddy, Changhu Chen
Journal: Neuro-Oncology (2015)

BACKGROUND: The initial results of this phase II clinical trial revealed a six-month progression-free survival of 90%, median PFS of 15.9 months and median overall survival of 16.3 months. We report here HRQoL that was assessed as a correlative study. METHODS: HRQoL was assessed using the European Organisation for Research and Treatment of Cancer (EORTC) quality of life questionnaire core-30 (QLQ-C30) and the EORTC brain cancer module (QLQ-BN20). Questionnaires were administered at baseline, completion of RT, 1 month post-RT, and every 3 months thereafter. Changes from baseline were calculated for each specific scale. A ≥ 10 point change in any scale from the mean baseline score was deemed significant. RESULTS: A total of 30 patients were treated on trial. HRQoL data was available for 28 patients (11 women; median age: 57 years [range, 31-72]; median KPS 80%). Compliance with assessments at baseline, completion of RT, 1 month post-RT, 3, 6, 9, and 12 months was 100, 96, 100, 86, 84, 52, and 30% respectively. Compared to baseline scores, there was no significant change in global health status, physical functioning, role functioning, emotional functioning, cognitive functioning or social functioning. No significant change was noted in nausea, pain, dyspnea, appetite, constipation, diarrhea, future uncertainty, visual disorder, communication deficit, headache, seizure, drowsiness or bladder control scores. Significant improvement was noted in financial, insomnia and fatigue scales. Significant worsening was noted in motor dysfunction, itchy skin, hair loss and weakness of legs. CONCLUSIONS: Treatment with hypo-IMRT combined with TMZ and BEV did not negatively impact overall HRQoL.
PTU-017 An audit of post ercp pancreatitis (pep) over four years in a uk tertiary centre
Authors: HL Adams, SS Jaunoo
Journal: Gut (2015)

<h3>Introduction</h3> The incidence of complications post ERCP is roughly 10%, with a reported mortality of around 1%. Pancreatitis (PEP) is the most common serious complication and although most are self-limiting, 10% develop severe pancreatitis resulting in considerable morbidity and occasional mortality. Determining incidence is difficult due to patient variation in selection for ERCP. This audit cycle over a four year period compares the incidence at a UK tertiary centre with the standard derived from guidance issued by the European Society of Gastrointestinal Endoscopy (ESGE). <h3>Method</h3> Data was collected retrospectively using clinical coding to identify patients with post ERCP pancreatitis between 01/04/2010 and 31/03/2014. Electronic hospital records were analysed using set criteria to select those undergoing ERCP and developing subsequent pancreatitis. <h3>Results</h3> 572 ERCPs were performed over this four year period. Nineteen patients undergoing ERCP in this time interval developed pancreatitis, with an incidence of 3.32%. Thirteen patients were female, and the median age at ERCP was 64 years. Most patients underwent ERCP due to gallstones however two patients had cholangiocarcinoma. Of the nineteen patients with PEP, five patients had been previously investigated with MRCP, and fourteen had received an upper abdominal ultrasound scan (USS). Three of the nineteen patients with PEP had an amylase level less than three times the upper limit of normal, however when compared with their baseline serum amylase, their post ERCP result was three times greater than their baseline level. <h3>Conclusion</h3> Incidence of PEP at the UK tertiary centre was within the standard set by ESGE guidelines. There are no recommendations for improvement however re-audit should occur after April 2014 and should be carried out prospectively with additional outcome measures such as 30-day mortality, haemorrhage, perforation, cholangitis and cardiorespiratory complications. <h3>Disclosure of interest</h3> None Declared.
Splenic artery aneurysm bleeding via the ampulla of Vater
Authors: Anna Pietrzak, Tomasz Olesiński, Jarosław Reguła, Edyta Zagórowicz, Jakub Pałucki, Andrzej Mróz
Journal: Endoscopy (2015)

Finding the cause of obscure-overt gastrointestinal (GI) bleeding is often a difficult and time-consuming process. Despite extensive research, up to 20 % of patients remain undiagnosed [1] [2]. We present the case of a 74-year-old man with a history of acute pancreatitis, who was hospitalized several times in district hospitals for hemodynamically significant, recurrent, GI bleeding.