tbuckley/cabot-search huggingface dataset:
Angiographic Visualization of an Atrial Myxoma
Authors: Jaber I. Sawaya, Habib A. Dakik
Journal: New England Journal of Medicine (2000)

< 1 8 .5 » 4 0 .0 1 8 .5 -2 0 .4 2 0 .5 -2 1 .9 2 2 .0 -2 3 .4 2 3 .5 -2 4 .9 2 5 .0 -2 6 .4 2 6 .5 -2 7 .9 2 8 .0 -2 9 .9 3 0 .0 -3 1 .9 3 2 .0 -3 4 .9 3 5 .0 -3 9 .9
Case 6-1991
Authors: James C. Melby, Austin L. Vickery
Journal: New England Journal of Medicine (1991)

A 27-year-old woman was admitted to the hospital because of Hodgkin's disease and a right adrenal mass.The patient was well until 2 1/2 months earlier, when she began to experience fatigue and a low-grade fever, with the temperature ranging as high as 37.6°C. Two months before admission pharyngitis developed, with cervical lymphadenopathy. One month before entry laboratory tests performed elsewhere showed that the urine was normal. The hematocrit was 34.9 percent, the white-cell count 6300, the platelet count 576,000, and the erythrocyte sedimentation rate 86 mm per hour. The urea nitrogen was 5.7 mmol per liter (16 mg per . . .
Induction of Airway BAFF during Upper Respiratory Infections in Patients with Asthma
Authors: Sergio E. Chiarella, Kathryn E. Hulse, Silvio Favoreto, Assel Biyasheva, Junquing Shen, Homer A. Boushey, Atsushi Kato, Robert P. Schleimer, Pedro C. Avila
Journal: Journal of Allergy and Clinical Immunology (2016)
Toxicity from Aluminum Antacids
Authors: David D. Ulmer
Journal: New England Journal of Medicine (1976)

Alumina, from the Latin alumen (substance with as-tringent taste), constitutes nearly 8 per cent of the earth's crust. It is the most plentiful of rhetals and, of all elements, is exceeded in abundance only by oxygen and silicon. Alumina does not occur naturally in the metallic state; however, in combination with other elements, it is widely distributed in rocks, clay, and soils in the form of gems such as ruby, sapphire, and turquoise, and in minerals of industrial importance such as alum, bauxite, cryolite, corundum, and kaolin. Although aluminum was not isolated until 1825, alum (hydrated aluminum sulfate) has been . . .
Carcinogenicity of 1-Methyl-1-nitrosourea in Nonhuman Primates2
Authors: R. H. Adamson, F. J. Krolikowski, P. Correa, S. M. Sieber, D. W. Dalgard
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Carcinogenicity of 1-Methyl-1-nitrosourea in Nonhuman Primates Get access R. H. Adamson, R. H. Adamson Search for other works by this author on: Oxford Academic PubMed Google Scholar F. J. Krolikowski, F. J. Krolikowski Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Correa, P. Correa Search for other works by this author on: Oxford Academic PubMed Google Scholar S. M. Sieber, S. M. Sieber Search for other works by this author on: Oxford Academic PubMed Google Scholar D. W. Dalgard D. W. Dalgard Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 2, August 1977, Pages 415–422, https://doi.org/10.1093/jnci/59.2.415 Published: 01 August 1977 Article history Received: 08 November 1976 Accepted: 01 March 1977 Published: 01 August 1977
Cancer Patients’ Plasma Lacking Lymphocytic Cortisol Metabolism-Enhancing Factor in Comparison With Plasma of Healthy Donors<xref ref-type="fn" rid="FN1">2</xref>
Authors: A Klein, H Kaufman, H Hoogervorst-Spalter, R Arie, S Mannheimer, R Fleminger, H Joshua
Journal: JNCI Journal of the National Cancer Institute (1979)

study was done to determine the influence of cancer-bearing patients’ plasma (CPP) on lymphocytic cortisol metabolism in comparllon with the plasma of healthy donors. Known concentrations of human lymphocytes were Incubated with cortisol in media containing 50% phosphate-buffered saline (PBS) and 50% of one of the following additions: .) homologic plasma (HP), b) heterologlc plasma (HetrP), c) HetrP obtained from patients who had diseases other than cancer and who were over the age of 70 years, d) CPP, e) boiled HP, t) boiled CPP, g) mixed plasma comprising 50% HP and 50% CPP, and h) PBS. All the plasmas had the capacity to enhance the lymphocytic cortisol metabolism rate when compared with the ability of PBS. There was no difference between the conversion rates obtained with the use of HP of healthy donors and those obtained with the use of HetrP of healthy donora, nor was there a difference between the rates obtained with the use of plasma of elderly patients and HP. CPP, however, led to significant reduction in activity. Mixing CPP with HP revealed that the reduced effect of the CPP was due to the lack of a factor or factors rather than the presence of inhibitory factors. Boiling of the HP and the CPP before incubation showed the presence of a temperature-labile factor in the HP and its absence in the CPP. This finding of a difference in the presence of a lymphocytic cortisol metabolism-enhancing factor between the plasma of cancer patients and the plasma of healthy donors may provide the basis for a new diagnostic aid for the early detection of cancer.
OC-041 Changes in the expression of cellular iron transport machinery occur in pre-neoplastic lesions within the colon in both sporadic and familial polyposis
Authors: M J Brookes, S Ford, G Caldwell, C Jones, T Iqbal, C Tselepis
Journal: Gut (2010)

<h3>Introduction</h3> Sporadic colorectal adenocarcinoma (CRC) develops through the adenoma-carcinoma sequence involving in the tumour suppressor gene adenomatous polyposis coli (APC). Familial adenomatous polyposis coli (FAP) is a condition in which germline mutations in APC lead to early adenoma and tumour formation. Mutations in APC lead to increased Wnt signalling, the main oncogenic pathway in colon cancer, upregulating c-myc. Increased expression of the cellular iron import proteins (TfR1 and DMT-1) are found in CRC, and lead to increased intracellular iron. The aim of this study is to determine whether these changes can be found in pre-cancerous adenomatous polyps in sporadic and familial adenomatous polyposis. <h3>Methods</h3> Colonic tissue from i) sporadic adenomas (n=15) and ii) familial adenomatous polyposis coli (n=10) was collected with matched normal colon. Real-time PCR was used to determine the expression of the iron transport proteins (TFR1, DMT1, ferroportin and ferritin) and c-myc. <h3>Results</h3> Sporadic and familial adenomatous tissue showed a significant fold increase in TfR1, DMT1 and c-myc expression in 15/25, 16/25 and 14/25 tissue samples, respectively. Furthermore both TfR1 and DMT1 were tightly correlated with c-myc expression (R<sup>2</sup>&gt;0.94 and 0.81, respectively). <h3>Conclusion</h3> This study demonstrates that changes in the expression of iron transport machinery occur in the pre-cancerous adenomatous polyps in both sporadic and familial polyposis and may be regulated by the oncogene c-myc.
Catamenial Hemoptysis Due to Bronchial Endometriosis
Authors: Melvin H. Rodman, Charles W. Jones
Journal: New England Journal of Medicine (1962)

ECTOPIC endometrial tissue has been reported in many locations, close to and distant from the pelvis. These have included lymph nodes (pelvic, iliac, mesenteric and inguinal), tissues close to the uterus (bladder, ureter, wall of small and large bowel, appendix, perineum, umbilicus and rectovaginal septum), operative scars and loci rather farther removed (kidney, arm — that is, the brachioradialis muscle — and leg). In addition there have been 3 reports of pleural location, 2 involving the pleural space alone1 2 3 and 1 with diffuse abdominal endometriosis4 involving the right side of the diaphragm, with a communication between the peritoneal and right . . .
<i>Rickettsia africae,</i>a Tick-Borne Pathogen in Travelers to Sub-Saharan Africa
Authors: Didier Raoult, Pierre E. Fournier, Florence Fenollar, Mogens Jensenius, Tine Prioe, Jean J. de Pina, Giuseppe Caruso, Nicola Jones, Herman Laferl, John E. Rosenblatt, Thomas J. Marrie
Journal: New England Journal of Medicine (2001)

African tick-bite fever occurs after contact with ticks that carry Rickettsia africae and that parasitize cattle and game. Sporadic reports suggest that this infection has specific clinical and epidemiologic features.We studied patients who were tested for a rickettsial disease after returning from a visit to Africa or Guadeloupe. To assess the value of the microimmunofluorescence assay, Western blotting, and cross-adsorption assays, we compared the results of these tests in 39 patients in whom African tick-bite fever had been confirmed by the polymerase-chain reaction assay, cell culture, or both; 50 patients with documented R. conorii infection; and 50 blood donors. These diagnostic criteria were then applied to 376 additional patients who had returned from southern Africa and 2 who had returned from Guadeloupe and whose serum was being tested for rickettsial disease.In the 39 patients with direct evidence of R. africae infection, the combination of microimmunofluorescence assay, Western blotting, and cross-adsorption assays showing antibodies specific for R. africae had a sensitivity of 0.56; however, each test had a positive predictive value and a specificity of 1.0. An additional 80 patients were found to have an R. africae infection on the basis of these serologic criteria. Infections with R. africae were acquired by visitors to 11 African countries and Guadeloupe. The illness was generally mild and was characterized by a rash in 46 percent of the patients; the rash was usually maculopapular or vesicular and rarely purpuric. Ninety-five percent of patients had an inoculation eschar or eschars, and 54 percent of these patients had multiple eschars, a finding that is unusual in patients with rickettsial infection.In this series, R. africae was the cause of nearly all cases of tick-bite rickettsiosis in patients who became ill after a trip to sub-Saharan Africa.
A prospective study of <sup>18</sup>FDG-pet scanning in preoperative melanoma patients
Authors: M. S. Brady, T. Akhurst, K. Spanknebal, M. Gonen, S. Hilton, D. Coit, S. Larson
Journal: Journal of Clinical Oncology (2004)

7520 Background: 18F-FDG PET scanning provides functional imaging based on glucose uptake by tumors. Preoperative PET scanning in high risk melanoma patients has the potential to alter clinical management by increasing the accuracy of detection of occult disease. Methods: We conducted a prospective trial to evaluate the additive utility of whole body 18FDG-PET scanning in addition to standard imaging (contrast-enhanced CT imaging of the chest, abdomen and pelvis) in preoperative stage III (T4N0M0,TanyN1–2M0) and stage IV (TanyNanyM1) patients. Nuclear medicine physicians and radiologists interpreted preoperative scans in a blinded fashion. The surgeon then reviewed these studies and a decision was scored as to whether to proceed with operation. Pathologic confirmation or clinical follow-up within 4 months were used to determine the accuracy of preoperative PET and CT scan findings. Results: 103 patients entered, 55 females and 48 males. Most patients (57/103, 55%) were considered for regional lymphadenectomy (47 therapeutic, 10 sentinel node directed). The remaining patients were evaluated for resection of metastatic disease (n=15), regional nodal and in-transit disease (n=15), or deep primary melanoma (n=12). Six patients were considered for resection or regional chemotherapy for local or in-transit disease. The addition of PET scanning to standard CT imaging led to a change in management in 34 of 103 patients (33%), and 20 of these were due to PET findings only. The most common decision was to cancel the operation because of the detection of occult metastatic disease (n=18). In most of these patients (13/18, 72%) this was due to findings on both CT and PET, and in 5/18 (28%) patients this was due to findings on PET only. While PET scanning was more sensitive than CT scanning in detecting occult metastatic disease (68% vs. 48%, p=0.05), both tests were highly specific (92% vs. 95%, p=0.7, PET vs. CT). Conclusions: PET scanning in addition to CT imaging increases detection of occult metastasis resulting in an alteration in clinical management in one third of high risk preoperative melanoma patients. PET imaging should be considered prior to operative intervention in this group of patients. No significant financial relationships to disclose.
Impairment of Endothelium-Dependent Pulmonary-Artery Relaxation in Chronic Obstructive Lung Disease
Authors: A. Tuan Dinh-Xuan, Timothy W. Higenbottam, Colin A. Clelland, Joanna Pepke-Zaba, George Cremona, A. Yazdani Butt, Stephen R. Large, Francis C. Wells, John Wallwork
Journal: New England Journal of Medicine (1991)

Endothelial cells release endothelium-derived relaxing factor (EDRF) in a variety of vascular beds, including the pulmonary circulation. However, the role of EDRF-mediated pulmonary-artery relaxation in chronic hypoxic lung disease is unknown.
Regional hepatic arterial chemotherapy for colorectal cancer metastatic to the liver: the controversy continues.
Authors: Y Z Patt
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.5.815 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8487044 Regional hepatic arterial chemotherapy for colorectal cancer metastatic to the liver: the controversy continues. Y Z PattxY Z PattSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.5.815 First Page PDF © 1993 by American Society of Clinical Oncology
Hepatocellular adenoma with malignant transformation in a patient with neonatal portal vein thrombosis
Authors: Lionel Arrivé, Jessica Zucman‐Rossi, Pierre Balladur, Dominique Wendum
Journal: Hepatology (2016)

Arrivé, Lionel; Zucman‐Rossi, Jessica; Balladur, Pierre; Wendum, Dominique Author Information
Shock Delivered by an Implantable Cardioverter–Defibrillator in Response to Spontaneous Ventricular Fibrillation
Authors: M Roelke, S S O'Nunain
Journal: New England Journal of Medicine (1995)

Figure 1. Stored bipolar intracardiac electrograms obtained from a 66-year-old man with an implantable cardioverter-defibrillator were retrieved during a routine office visit. The patient had reported a brief episode of lightheadedness followed by a sudden jolt in his chest. He remained conscious. The intracardiac electrograms are recorded from a right ventricular rate-sensing lead. The initial rhythm is sinus, with characteristic intracardiac recordings analogous to the QRS complex and the T wave. Rapid ventricular tachycardia developed spontaneously and degenerated into ventricular fibrillation. The rapid ventricular rate was detected by the cardioverter-defibrillator, which delivered a high-energy DC shock. Defibrillation restored sinus rhythm. . . .
Transvisceral Cyst Enterostomy and Cyst Gastrostomy for the Treatment of the Postinflammatory Pancreatic Pseudocyst
Authors: Melvin P. Osborne, Louis N. Pernokas
Journal: New England Journal of Medicine (1961)

BRANDENBERG, Maddock and Schweitzer1 reported the treatment by transgastric cyst gastrostomy of 2 patients with pancreatic pseudocysts and pancreatitis in 1951. Maddock suggested this procedure, which had been described in the European surgical literature2 but had not been reported in this country up to that time. The patients mentioned in the 1951 report have remained well, and transvisceral cyst enterostomy or cyst gastrostomy has been performed on 8 more patients. The present report is concerned with these 10 patients, who have been followed for periods up to twelve years.PatientsThe clinical material consists of 8 patients treated in this . . .
MTR-01BEVACIZUMAB-INDUCED MIF DEPLETION: A NOVEL RESISTANCE MECHANISM IN GLIOBLASTOMA
Authors: Brandyn Castro, Arman Jahangiri, Ruby Kuang, Michael De Lay, Gary Kohanbash, Garima Yagnik, Liane Miller, Shruti Shrivastav, Hideho Okada, Manish Aghi
Journal: Neuro-Oncology (2015)

Clinical trials revealed limited response duration of glioblastomas to the anti-angiogenic therapy bevacizumab, a VEGF-neutralizing antibody. Bevacizumab-resistant glioblastomas exhibit increased invasiveness and 50% more tumor-associated macrophages (TAMs), which can be of classical M1 or pro-tumoral M2 subtypes. As macrophage migration inhibitory factor (MIF) regulates tumor invasion and macrophage recruitment, we investigated MIF's role in bevacizumab resistance in glioblastoma. Patient bevacizumab-resistant glioblastomas exhibited 2-fold less MIF protein than bevacizumab-naive glioblastomas (n = 10; p < 0.05). Bevacizumab-resistant xenografts exhibited 6-fold less MIF protein and increased invasiveness than isogeneic bevacizumab-responsive xenografts (p < 0.05). Immunoprecipitation revealed that bevacizumab bound MIF, likely reflecting its 30% homology to the VEGF protein structure. Furthermore, VEGF stimulation of U87 cells in vitro increased MIF transcription and secretion 5-fold (p < 0.05), suggesting VEGF depletion as another mechanism of MIF downregulation. Site-directed biopsies of bevacizumab-naive glioblastomas revealed enriched MIF expression at the enhancing tumor margin, which was lost in bevacizumab-resistant glioblastomas (p < 0.05). A similar regional pattern of expression was seen with VEGF, supporting its role in stimulating tumor cell MIF secretion. Continued bevacizumab treatment of bevacizumab-resistant xenografts increased M2-like CD11b+ TAMs, 3-fold, with preferential localization at the tumor margin (p < 0.05). The same pattern of recruitment and polarization was seen in U87/MIF-shRNA relative to U87/control-shRNA intracranial xenografts (p < 0.05). When co-cultured with cells from bevacizumab-resistant xenografts or U87/MIF-shRNA cells, bone marrow matured to an M2-like phenotype (p < 0.05), while an M1-like phenotype was generated with addition of recombinant MIF in a dose-dependent manner (p < 0.05). In conclusion, MIF expression is enriched at the glioblastoma margin, a pattern that may create a perimeter of inflammatory M1-like TAMs. This pattern is lost with bevacizumab resistance, likely due to bevacizumab-induced MIF depletion and diminished VEGF-induced MIF upregulation. MIF depletion leads to M2-like TAM polarization and recruitment to the tumor margin, thus softening the tumor border and promoting invasive bevacizumab resistance.
The Treatment of Polycythemia Vera by Spray Irradiation
Authors: Wyman Richardson, Laurence L. Robbins
Journal: New England Journal of Medicine (1948)

IN 1932 the treatment of polycythemia vera by spray irradiation was instituted at the Massachusetts General Hospital by the Department of Radiology at the suggestion of Dr. Francis T. Hunter. The results of treatment at the end of a ten-year period were presented by Robbins.1 The purpose of this study is to report upon the present status of the original group of patients and also upon the results of treatment in 8 additional patients. This method of treating polycythemia vera has proved the most successful of any of the procedures that have been tried at this hospital, and it has . . .
Molecular Alterations and Everolimus Efficacy in Human Epidermal Growth Factor Receptor 2–Overexpressing Metastatic Breast Cancers: Combined Exploratory Biomarker Analysis From BOLERO-1 and BOLERO-3
Authors: Fabrice André, Sara Hurvitz, Angelica Fasolo, Ling-Ming Tseng, Guy Jerusalem, Sharon Wilks, Ruth O’Regan, Claudine Isaacs, Masakazu Toi, Howard A. Burris, Wei He, Douglas Robinson, Markus Riester, Tetiana Taran, David Chen, Dennis Slamon
Journal: Journal of Clinical Oncology (2016)

Two recent phase III trials, BOLERO-1 and BOLERO-3 (Breast Cancer Trials of Oral Everolimus), evaluated the addition of everolimus to trastuzumab and chemotherapy in human epidermal growth factor receptor 2-overexpressing advanced breast cancer. The current analysis aimed to identify biomarkers to predict the clinical efficacy of everolimus treatment.Archival tumor samples from patients in BOLERO-1 and BOLERO-3 were analyzed using next-generation sequencing, immunohistochemistry, and Sanger sequencing.Biomarker data were available for 549 patients. PIK3CA activating mutations and PTEN loss were reported in 30% and 16% of BOLERO-1 samples and in 32% and 12% of BOLERO-3 samples, respectively. PI3K pathway was hyperactive (PIK3CA mutations and/or PTEN loss and/or AKT1 mutation) in 47% of BOLERO-1 and 41% of BOLERO-3 samples. In both studies, differential progression-free survival (PFS) benefits of everolimus were consistently observed in patient subgroups defined by their PI3K pathway status. When analyzing combined data sets of both studies, everolimus was associated with a decreased hazard of progression in patients with PIK3CA mutations (hazard ratio [HR], 0.67; 95% CI, 0.45 to 1.00), PTEN loss (HR, 0.54; 95% CI, 0.31 to 0.96), or hyperactive PI3K pathway (HR, 0.67; 95% CI, 0.48 to 0.93). Patients with wild-type PIK3CA (HR, 1.10; 95% CI, 0.83 to 1.46), normal PTEN (HR, 1.00; 95% CI, 0.80 to 1.26), or normal PI3K pathway activity (HR, 1.19; 95% CI, 0.87 to 1.62) did not derive PFS benefit from everolimus.This analysis, although exploratory, suggests that patients with human epidermal growth factor receptor 2-positive advanced breast cancer having tumors with PIK3CA mutations, PTEN loss, or hyperactive PI3K pathway could derive PFS benefit from everolimus.
Transfusion Medicine — Blood Transfusion
Authors: Lawrence T. Goodnough, Mark E. Brecher, Michael H. Kanter, James P. AuBuchon
Journal: New England Journal of Medicine (1999)

Blood transfusion and blood conservation (techniques or strategies to avoid the need for blood) are complementary activities that constitute the clinical arena of transfusion medicine. Recent improvements in the safety of the blood supply and the increasing costs associated with transfusion therapies have led to a reevaluation of the clinical practices of blood transfusion and blood conservation. Among the issues that have been reevaluated are the threshold for transfusion at which the benefits outweigh the risks and the identification of patients most likely to benefit from blood conservation. This review summarizes recent developments in transfusion medicine that have affected the . . .
Apolipoprotein A-I as a Marker of Angiographically Assessed Coronary-Artery Disease
Authors: James J. Maciejko, David R. Holmes, Bruce A. Kottke, Alan R. Zinsmeister, Dac M. Dinh, Simon J. T. Mao
Journal: New England Journal of Medicine (1983)

This study was designed to determine whether the plasma level of apolipoprotein A-I is a better discriminator of angiographically documented coronary-artery disease than the level of high-density-lipoprotein (HDL) cholesterol in male subjects. The level of plasma apolipoprotein A-I in 83 patients with coronary-artery disease was 96.7 +/- 4.2 mg per deciliter (mean +/- S.E.M.), which was significantly lower (P less than 0.0001) than the level in 25 patients without coronary-artery disease (146.9 +/- 2.1 mg per deciliter). The levels of HDL cholesterol were also lower (P less than 0.0001) in patients with coronary-artery disease (31.9 +/- 1.5 mg per deciliter) than in those without it (45.9 +/- 2.3 mg per deciliter). A stepwise discriminant analysis, however, indicated the superiority of apolipoprotein A-I over HDL cholesterol in detecting coronary-artery disease. Furthermore, a linear discriminant analysis suggested that although HDL cholesterol by itself was a discriminator of coronary-artery disease, it did not provide a substantial increase in discriminatory value over that provided by apolipoprotein A-I; in contrast, apolipoprotein A-I levels added discriminatory value to the information obtained by measuring HDL cholesterol alone. We conclude that apolipoprotein A-I by itself is more useful than HDL cholesterol for identifying patients with coronary-artery disease.