tbuckley/cabot-search huggingface dataset:
Abstract 1408: The insulin-like growth factor receptor I and Pyk2 kinase are up-regulated in urothelial carcinomas and promote motility and invasion of urothelial carcinoma-derived cells
Authors: Marco Genua, Shi-Qiong Xu, Leonard G. Gomella, Renato V. Iozzo, Andrea Morrione
Journal: Cancer Research (2011)

Abstract The insulin-like growth factor receptor I (IGF-IR) plays an essential role in transformation by promoting cell growth and protecting cancer cells from apoptosis. We have recently demonstrated that the IGF-IR is overexpressed in invasive bladder cancer tissues and promotes motility and invasion of urothelial-carcinoma-derived cells. Significantly, IGF-IR activation did not affected cell proliferation, suggesting that the IGF-IR may play a more prominent role in promoting the transition to the invasive phenotype in bladder cancer. In this study we demonstrated by immunohistochemical analysis that the IGF-IR expression increased with grade in bladder cancer tissues compared to non-malignant controls. Increased IGF-IR expression in non-tumorigenic T24 urothelial carcinoma cells promoted anchorage independent growth, while targeting of endogenous IGF-IR by shRNA approaches in metastatic T24T cells inhibited colony formation in soft-agar. We also discovered that the focal adhesion protein Pyk2 kinase is activated by IGF-I in urothelial carcinoma-derived cells. Using siRNA approaches, we demonstrated that Pyk2 is critical for IGF-IR-dependent motility and invasion of urothelial cancer cells. In addition, Pyk 2 is critical for IGF-I-dependent activation of the Akt and MAPK pathways, which are critical in the regulation of motility and invasion. Using immunofluorescence and AQUA (Automated Quantitative Analysis) analysis we also discovered that Pyk2 is overexpressed in bladder cancer tissues compared to normal tissue controls. In urothelial carcinoma-derived tissues there is also increased Pyk2 localization in the nucleus compared to normal tissue controls. Our results provide the first evidence for a role of the IGF-IR and Pyk2 in motility and invasion of bladder cancer cells, and support the hypothesis that the IGF-IR and Pyk2 may play a critical role in the establishment of the invasive phenotype in urothelial neoplasia. The IGF-IR and Pyk2 could represent novel molecular targets in bladder cancer and could also serve as a novel tumor biomarkers for diagnosis and possibly prognosis of bladder tumors. This work has been supported by the Benjamin Perkins Bladder Cancer Fund, the Martin Greitzer Fund and National Institutes of Health Grants RO1 DK068419 (A.M.) and RO1 CA39481 and RO1 CA047282 (R.V.I.). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1408. doi:10.1158/1538-7445.AM2011-1408
Synchronous giant gastric gastrointestinal stromal tumor and gastric malignant melanoma
Authors: Barış Yılmaz, Fuat Ekiz, Akif Altınbas, Bora Aktaş, Suleyman Altıntas
Journal: Endoscopy (2014)

A 63-year-old man was admitted to our clinic with a 2-month history of epigastric pain and dyspeptic complaints. He had no history of any disease and his vital signs were within normal limits. Physical examination revealed a palpable abdominal mass. Laboratory tests showed unremarkable findings. Upper gastrointestinal endoscopy revealed a crater-like ulcer, approximately 3 cm in diameter, in the anterior wall of the gastric body, and compression on the posterior wall of the stomach ([Fig. 1]). The esophagus and duodenum were unremarkable. Histopathological analysis of an endoscopic biopsy sample from the ulcer revealed malignant melanoma. Abdominal computed tomography showed a large, heterogeneous, cystic solid tumor 15 cm in diameter, compatible with gastrointestinal stromal tumor (GIST), originating from the posterior wall of the stomach ([Fig. 2]). Percutaneous biopsy was performed. A diagnosis of GIST was confirmed by histopathological findings. The patient was referred to the surgery and medical oncology departments.
PTU-023 Long-term outcomes following drug-eluting bead transarterial chemoembolisation (DEB-TACE) as part of multimodality treatment for hepatocellular carcinoma
Authors: C Lever, P Kumar, S George, N Hacking, B Stedman, D Breen, N Pearce, M Wright
Journal: Gut (2012)

<h3>Introduction</h3> Treatment protocols for hepatocellular carcinoma (HCC) are evolving rapidly. We sought to determine long-term outcomes in patients with HCC treated with DEB-TACE as stand alone or part of multimodality treatment at a single centre. <h3>Methods</h3> Our departmental database of HCC, diagnosed using EASL radiological criteria, was reviewed retrospectively. From August 2006 to January 2011, 80 patients (60 males/20 females) underwent DEB-TACE some of which also had surgery and/or percutaneous ablation. A total of 186 episodes of DEB-TACE treatment were performed (minimum 1 episode and maximum 8 episodes per patient). 37.5% of patients presented with multifocal disease, a further 7.5% presented with tumour plus satellites. The mean MELD (model for end-stage liver disease) in this cohort was 9.53 (range 6–22). Demographics, procedural details, clinical measures and outcomes were studied. Median age was 69 years (range 33–87). All patients were included in the survival analysis. Overall survival was described using Kaplan–Meier methods. <h3>Results</h3> 53 patients with a median tumour size of 49 mm (range 12–163 mm) were treated with DEB-TACE alone with a mean number of procedures of 2.1. Here median survival was 28.5 months (798 days). The 1- and 3-year survival rates in this group where 66% and 38% respectively. 27 patients (median tumour size of 40 mm (range 12–100 mm)) were treated with a combination of therapies and at 55 months (1540 days) the median survival had not been reached. Survival in this group was 51.1% at time data collection. In this group the 1- and 3-year survival rates were 86% and 64% respectively. In our cohort of patients DEB-TACE both with or without combination therapies, resulted in median survival of 44 months. Overall survival rates at 1- and 3-years were 74.5% and 50.3% respectively. There were no deaths at 30 days following a DEB-TACE episode. <h3>Conclusion</h3> In our centre this procedure is safe and well tolerated with multimodality treatment showing an improved survival outcome. Our results highlight the importance of a multidisciplinary approach with the application of multimodal therapy in the management of HCC with an improved survival for appropriately selected patients. <h3>Competing interests</h3> None declared.
Abstract 5002: Abstract Submission
Authors: Swati Acharya, Kira Y.D Petersen, Vladislav Golubkov, Mandy Kwong, Christopher M. Adams, Peter K. Jackson, David B. Lewis
Journal: Cancer Research (2015)

Abstract Protein tyrosine kinase 7 (PTK7), a catalytically inactive receptor tyrosine kinase (RTK) that is highly expressed by T-lineage cells during intrathymic development, is a novel marker for human CD4+ recent thymic emigrants (RTEs), and is also highly expressed on some T-lineage thymomas, e.g., Jurkat cells as well as inprimary T-Acute Lymphoblastic leukemia. The function of PTK7 in normal human T-cell development and in oncogenesis remains unclear. Here, using RNAi-mediated gene silencing in T-lineage tumor cells, primary human peripheral T-cells, and thymocytes, we found that targeting PTK7 consistently decreased cell survival by augmenting caspase-3 activation of apoptosis. The PTK7 knockdown also decreased AKT phosphorylation and PI3 kinase activity, suggesting an essential role for PTK7 in survival of RTEs and developing thymocytes involving the PI3K/AKT pathway. Using mass spectrometry we identified insulin-like growth factor-1 (IGF-1) receptor as an active kinase partner of PTK7. This interaction was biologically relevant in that PTK7 downregulation also reduced IGF-1R-dependent survival signals in T-lineage cells. As enhanced IGF-1-dependent signaling is a frequent event in oncogenesis, the intersection of PTK7 with the IGF-1 signaling pathway suggests the potential of PTK7-directed therapy of T-lineage tumors. Citation Format: Swati Acharya, Kira Y.D Petersen, Vladislav Golubkov, Mandy Kwong, Christopher M. Adams, Peter K. Jackson, David B. Lewis. Abstract Submission. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5002. doi:10.1158/1538-7445.AM2015-5002
The Use of Low-Dose Intravenous Insulin in Clinical Myocardial F-18 FDG PET Scanning
Authors: PETRA LEWIS, TOM NUNAN, ANGELA DYNES, MICHAEL MAISEY
Journal: Clinical Nuclear Medicine (1996)

The effectiveness of low-dose intravenous insulin boluses to improve study quality in F-18 FDG myocardial scans is investigated. Seventeen patients were imaged using a protocol in which only diabetic patients with fasting blood glucose levels > 8 mmol/l were given insulin. Fifty-three patients were imaged using a protocol in which all patients were given 1-3 IU intravenously of insulin immediately before F-18 FDG injection, based on fasting blood glucose levels. Scan quality was rated as poor, good, or excellent. Using the conventional protocol, 29% of the scans were poor quality (uniterpretable), 47% were good, and 23% were excellent. Using the low-dose intravenous insulin boluses protocol; 2% were poor, 53% were good, and 45% were excellent (P = 0.01). There were no significant differences in the proportion of diabetic patients, age, or fasting blood glucose levels. Low-dose intravenous insulin bolus is an easy and safe method of improving myocardial F-18 FDG scan quality in nondiabetic and diabetic patients.
Abstract 984: Planning for caHUB, NCI's cancer human biobank
Authors: Carolyn Compton, Anthony Dickherber, Ian Fore, Nicole Lockhart, Mark David Lim, Helen Moore, Kimberly Myers, Joyce Rogers, Sherilyn Sawyer, Priyanga Tuovinen, Jimmie Vaught
Journal: Cancer Research (2010)

Abstract Many high-profile NCI initiatives are significantly impacted by biospecimen availability and quality. One of the newly delineated developmental pathways for transforming scientific discoveries into new clinical modalities for oncology, defined by NCI's Translational Research Working Group, is entirely biospecimen-based and is similarly impacted. Both direct experience with these initiatives as well as broader input from the scientific community, including recent results from a market research survey, have indicated a striking unmet need for high-quality human biospecimens. In response to this need, the Office of Biorepositories and Biospecimen Research (OBBR) is planning for the implementation of the cancer Human Biobank (caHUB). No centralized resource of this type exists at this time. This initiative will take advantage of resources already developed by the NCI, including the OBBR Biospecimen Research Network (BRN) and the NCI Best Practices for Biospecimen Resources (http://biospecimens.cancer.gov/practices/). The OBBR is engaging in a detailed process with a variety of planning groups, to address the requirements for implementation of caHUB. caHUB will acquire and make available to the research community biospecimens that have been collected according to the highest technical and ethical standards; provide biospecimen reference samples that serve as benchmarks for specimen integrity and molecular type; conduct research that supports evidence-based biospecimen best practices; and create opportunities for collaboration and information exchange across the research enterprise. caHUB will ensure the quality of its inventory by acquiring biospecimens that have been collected and processed according to evidence-based standard operating procedures, annotated with comprehensive clinical, molecular, and collection data, and procured from patients who received high-quality care. caHUB proposes to contract with military, community, and academic institutions to collect biospecimens and their associated data. Through a caBIG®-compliant public network, caHUB will make specimens and data available to a broad research community, including academia, government, private foundations, and biotechnology and pharmaceutical industries, and enable new collaborations among researchers in all areas of investigation, thereby accelerating the pace of discovery and innovation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 984.
Surgical Treatment of Subclavian-Artery Occlusions
Authors: H. Brownell Wheeler
Journal: New England Journal of Medicine (1967)

CEREBROVASCULAR insufficiency due to subclavian-artery occlusion is more frequent, more simply diagnosed and more easily treated than generally recognized. Only recently has attention been focused on this condition, chiefly since the description of the "subclavian steal syndrome" in 1961. Physicians who treat patients with cerebrovascular disease should become familiar with this diagnosis, since in selected cases, dramatic relief of symptoms can be obtained from arterial reconstructive surgery.The current article reviews a five-year personal experience with the management of 22 patients with occlusions of the subclavian artery. Nine patients were not deemed sufficiently symptomatic to warrant surgery and have been . . .
Endoscopic removal of a migrated stent in the gallbladder
Authors: Tomonori Ida, Masahiko Inamori, Jun Hamanaka, Hideyuki Chiba, Akihiko Kusakabe, Taiki Morohashi, Atsushi Nakajima, Shin Maeda, Toru Goto
Journal: Endoscopy (2014)

An 84-year old man was admitted to our hospital with fever and abdominal pain. An abdominal computed tomography (CT) scan revealed evidence of acute cholecystitis ([Fig. 1]). Percutaneous transhepatic gallbladder drainage was performed and his symptoms improved; however, cholecystectomy could not be performed because the patient's heart function was too poor.
Abstract 2796: Suppressive effect of DNA hypomethylation on gastric carcinogenesis
Authors: Hiroyuki Tomita, Akihiro Hirata, Yasuhiro Yamada, Akira Hara
Journal: Cancer Research (2011)

Abstract Global DNA hypomethylation and concomitant site-specific gene hypermethylation are among the most common molecular alterations in human neoplasia. Although site-specific DNA hypermethylation has been shown to be associated with the development of various tumors accompanied by transcriptional silencing of target genes, the functional significance of global DNA hypomethylation in tumorigenesis remains unclear. Previous studies have revealed that a genetic reduction of the DNA methylation levels leads to opposing effects on tumor development, depending on the tumor cell type and the stage of tumorigenesis. In the present study, we investigated the effect of DNA hypomethylation on gastric carcinogenesis in mice. DNA methyltransferase 1 (Dnmt1) hypomorphic mice, which showed that Dnmt1 hypomorphic alleles induced global DNA hypomethylation in the gastric mucosa, were used in this study. The genetic reduction of DNA methylation levels suppressed the incidence, number and size of gastric tumors in two different mouse models for gastric tumorigenesis: the N-methyl-N-nitrosourea (MNU)-induced model and the Apc (Min/+) mouse model that spontaneously develops gastric tumors with aging. Histological analyses revealed DNA hypomethylation to completely inhibit the development of invasive gastric tumors. In the MNU model, DNA hypomethylation reduced the persistent increase in the cell proliferative activity in the non-cancerous gastric mucosa exposed to MNU. However, the aberrant site-specific methylations were not found in MNU-induced mouse gastric tumors unlike in the case of human gastric tumors, thus indicating that the pattern of the site-specific aberrant methylations in mouse gastric tumors is distinctly different from that in human gastric cancers. Taken together, these findings indicate that the reduction of DNA methylation levels suppresses gastric carcinogenesis and suggest that DNA methylation is closely associated with gastric tumorigenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2796. doi:10.1158/1538-7445.AM2011-2796
EU nations approve law to overhaul clinical trials
Authors: R. Watson
Journal: BMJ (2013)

European Union governments have given their support to pan-European legislation that would speed up authorisation procedures for clinical trials and ensure that all trials were registered in a central database and their results made publicly available.

The new measures, which had been politically agreed by governments and the European Parliament in the second week of December, will replace rules that have operated since 2001 with simpler, more uniform requirements. The current rules have been widely criticised for being excessively bureaucratic, leading to a sharp decline in the European Union in trials of drugs for humans. In 2007 the number of …
Mutation in Kras Codon 13, but not in Codon 12, Correlates with Poor Prognosis in Colorectal Cancer: a Cohort Study
Authors: Sakarias Wangefjord, Nooreldin Zendehrokh, Björn Nodin, Magnus Sundström, Karin Jirström, Jakob Eberhard
Journal: Annals of Oncology (2013)
Successful removal from the esophagus of a self-expandable metal stent that had shriveled up into a tangled ball
Authors: Gianfranco Donatelli, Parag Dhumane, Bertrand Vergeau, Jean-Loup Dumont, Thierry Tuszynski, Bruno Meduri
Journal: Endoscopy (2013)

A 39-year-old woman developed a leak from the cardia following a sleeve gastrectomy. She underwent placement of an 18-cm Niti-S covered esophageal self-expandable metal stent (SEMS; TaeWoong Medical, Gimpo, Korea) at the gastroesophageal junction ([Fig. 1 a]).
Evidence for Disordered Control of 1,25-Dihydroxyvitamin D Production in Absorptive Hypercalciuria
Authors: Arthur E. Broadus, Karl L. Insogna, Robert Lang, Alice F. Ellison, Barbara E. Dreyer
Journal: New England Journal of Medicine (1984)

In previous studies, we observed increases in the circulating concentration and production rate of 1,25-dihydroxyvitamin D (1,25-(OH)2D) in a large majority of patients with the syndrome of absorptive hypercalciuria. In the present study, the hypothesis that 1,25-(OD)2D production might be relatively autonomous in this syndrome was tested by fashioning a suppression test in which patients were challenged with a short-term increase in dietary calcium intake. We found that contrary to our hypothesis, the circulating concentration of 1,25-(OH)2D was remarkably sensitive to calcium intake in 15 inpatients with absorptive hypercalciuria (mean decrease, from 74 to 49 pg per milliliter, P<0.001). When this challenge was prolonged for two weeks, however, patients with absorptive hypercalciuria had evidence of an apparent "escape" phenomenon, in which the circulating concentration of 1,25-(OH)2D rebounded toward its initial level and the renal tubular phosphate threshold fell markedly. These findings provide evidence for disordered control of renal phosphate handling and 1,25-(OH)2D production in absorptive hypercalciuria and suggest a linked rather than a cause- and-effect relation between these two abnormalities. (N Engl J Med 1984; 311:73–80.)
Trends in influenza vaccination behaviours – results from the CoPanFlu cohort, France, 2006 to 2011
Authors: A L Caille-Brillet, J Raude, N Lapidus, X De Lamballerie, F Carrat, M Setbon
Journal: Eurosurveillance (2013)

Controversies over the effectiveness and safety of the pandemic influenza A(H1N1)pdm09 vaccine in 2009/10 may have altered the influenza vaccination coverage in France after the pandemic season. The purpose of this study was to determine whether the pandemic affected seasonal influenza vaccination behaviours in the general population by analysing vaccination behaviours from 2006/07 to 2011/12 among the 1,451 subjects of the Cohort for Pandemic Influenza (CoPanFlu) France. We found that vaccination behaviours in 2010/11 and 2011/12 significantly differed from behaviours before the pandemic, with the notable exception of the targeted risk groups for seasonal influenza-related complications. Among the population with no risk factors, the post-pandemic influenza vaccine coverage decreased, with people aged 15 to 24 years and 45 to 64 years being most likely to abandon vaccination. Therefore, this study documents a moderate negative effect of the 2009/10 pandemic episode on vaccination behaviours in the French metropolitan population that was apparent also in the following two seasons. Moreover, it does not exclude that the general trend of reduced vaccination has also affected certain targeted groups at high risk for complications.
TCT-786 In-Hospital Outcomes of balloon aortic valvuloplasty and percutaneous coronary intervention during the same hospitalization in the US
Authors: Vikas Singh, Nileshkumar J Patel, Apurva Badheka, Nilay Patel, Conrad Macon, Ghanshyambhai T Savani, Jay Patel, Badal Thakkar, Sohilkumar Manvar, Vinaykumar Panchal, Shantanu Solanki, Neil Patel, Ankit Chothani, Chad Kliger, Theodore Schreiber, William W O'Neill, Mauricio G Cohen, Carlos Alfonso, Cindy Grines, John K Forrest, Michael Cleman, Raj Makkar
Journal: Journal of the American College of Cardiology (2014)
Self-deception: Adaptation or by-product?
Authors: Hugo Mercier
Journal: Behavioral and Brain Sciences (2011)

Abstract By systematically biasing our beliefs, self-deception can endanger our ability to successfully convey our messages. It can also lead lies to degenerate into more severe damages in relationships. Accordingly, I suggest that the biases reviewed in the target article do not aim at self-deception but instead are the by-products of several other mechanisms: our natural tendency to self-enhance, the confirmation bias inherent in reasoning, and the lack of access to our unconscious minds.
EVALUATION SERIES ON SAFETY AND EFFICACY OF NUTRITIONAL SUPPLEMENTS IN PATIENTS WITH NEWLY DIAGNOSED HYPERLIPIDEMIA
Authors: Ravi R. Kasliwal, Manish Bansal, Rajeev Gupta, Siddharth Shah, Sameer Dani, Abraham Oomman, Vikas Pai, Naresh Trehan
Journal: Journal of the American College of Cardiology (2015)