tbuckley/cabot-search huggingface dataset:
AB1476-HPR Complications after silicon metocarpophalangeal artroplasty in patiants with rheumatoid arthritis
Authors: S. Makarov, M. Makarov, Y. Khrennikoff, M. Lipina, D. Ivanoff, V.V. Kolomatsky, A. Roskidailou
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Metacarpophalangeal joint artroplasty in patient with rheumatoid arthritis and another arthritic conditions could improve a range of motion, functional ability and appearance of the hand. Implants used for this procedure commonly made of silicon elastomer. But since their introducing we have a lot of reports about complications. In this abstract we present our analysis of complications after silicom metacarpophalangeal artroplasty (SMPA).The purpose of the study was to evaluate the mid-term results after SMPA in patients with RA. <h3>Objectives</h3> The purpose of the study was to assess a complications after SMPA and their influence on result. <h3>Methods</h3> From 2004 till 2011 were performed 275 SMPAs. All patients with exception of one man were women. Average age was 39,7 years. Mean follow up was 21,7 months. For 72 imlants (14 women) mean follow up was 4,27 years. Patients were assessed for active range of motion (ROM), extension deficiency and ulnar drift. Futhermore after 12 and 24 months were perform X-ray examination. <h3>Results</h3> Mean ROM before operation was 38,4°, average ROM after operation was 54,76°. Average extension deficiency before operations was 27,8°, after - 6,32°. Average ulnar deviation 37° and 7,89° respectively. 84 from 275 implants have a clear signs of the implant damage (subsidence or collapse of the joint space, phalangeal dislocations). But in spite of this there was only 5 revisions (8 imlants) due to unsatisfactory results. In 1 case was a deep infection with implant removing. In 1 case was a bad appearance of the hand (25 years old woman) due to "bayonet" deformity without any loss of function. Another 3 women (6 imlants) had a silicon sinovitis in II and III fingers due to trauma and overcorrection of the ulnar drift. In these cases imbalance of the soft tissue leads to implant overload and silicon microparticle producing. In these cases imlants were roken and their "color" was significantly differ than in new implant. Biopsy did't show any signs of "rheumatoud" process. <h3>Conclusions</h3> The rate of complications was 2,9% that almost a same in hip and knee arhroplasty. Rate of the implant fractures was 30,9%. All cases of the silicon sinovitis were caused by implant fractures due to bad soft tissue balance and ulnar drift over correction. In spite of complications SMPA has a good satisfactory rate in patients with rheumatic diseases. <h3>Disclosure of Interest</h3> None Declared
421 OCCULT HEPATITIS B VIRUS INFECTION AMONG HEPATOCELLULAR CARCINOMA PATIENTS IN JAPAN
Authors: J. Muto, M. Mukaide, M. Sugiyama, S. Hiramine, T. Takeda, T. Aoki, T. Matsui, N. Nishida, M. Imamura, M. Korenaga, K. Murata, N. Masaki, K. Shirabe, Y. Maehara, M. Mizokami
Journal: Journal of Hepatology (2013)
P750Characterisation of the effects of sex and oestrogen receptor beta in the mouse cardiac proteome under pressure overload
Authors: G Kararigas, D Fliegner, S Forler, O Klein, C Schubert, J Klose, V Regitz-Zagrosek
Journal: Cardiovascular Research (2014)

Purpose: The response of the heart to pressure overload (PO) differs considerably between males and females. We and others have previously shown that oestrogen receptor (ER) β may be cardioprotective. However, the underlying mechanisms remain incompletely defined. Our aim was the analysis of the effects of sex and ERβ in PO applying a proteomic approach. Methods: Two-month-old C57BL6 male (M) and female (F) wild-type (WT) and ERβ knockout (BERKO) mice were subjected to transverse aortic constriction (TAC) or sham surgery (n = 4/group). The proteome of left ventricular samples was separated by high-resolution 2-dimensional polyacrylamide gel electrophoresis. The proteomic data were analysed with empirical Bayesian-based linear models using the R and Bioconductor software. Results: At nine weeks post operation, TAC led to a greater increase in heart-weight-to-tibia-length ratio in WT M (TAC vs. sham 128%; P < 0.05) than in WT F (TAC vs. sham 54%; P < 0.05) mice, while this difference in BERKO mice between M (TAC vs. sham 53%; P < 0.05) and F (TAC vs. sham 55%; P < 0.05) was abolished. With the present proteomic approach, we were able to identify and analyse a total of 795 left ventricular protein spots. Our comparative proteomic analysis revealed that in WT M and F mice 82 and 31 protein spots, respectively, differed between sham and TAC (P ≤ 0.05). In BERKO M and F mice we found 114 and 87 altered protein spots, respectively (P ≤ 0.05). Overall, mitochondrial bioenergetics- and oxidative stress-related proteins were modulated. We also found that trifunctional enzyme subunit family members were repressed in M-WT-TAC mice, while cytoskeletal proteins were induced in F-WT-TAC mice. On the other hand, heat shock proteins were induced in both M and F-BERKO-TAC mice. Conclusions: Our findings demonstrate that both sex and ERβ influence the proteomic response of the heart to PO. Collectively, we consider our study a useful resource for the unravelling of the effects of sex and ERβ in PO.
THU0030 Evidence for good intrinsic mesenchymal stem cell activity in gelatinous heberden’s nodes in osteoarthritis at clinical presentation
Authors: T. Baboolal, S. Boxall, C. Buckley, A.L. Tan, S. Churchman, S. Calder, D. Kouroupis, P. Giannoudis, R. Hodgson, E. Jones, D. McGonagle
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Heberden's nodes (HN) are common pre-radiographic features of generalised osteoarthritis (GOA) and they may present as acute cystic lesions before eventually leading to florid new bone formation [1]. <h3>Objectives</h3> To examine if the gelatinous material from Heberden's nodes "synovial cysts" contained multipotential mesenchymal stromal cells (MSCs), and whether such cells were of bone marrow or synovial fluid origin and to link the findings to joint structure especially articular cartilage integrity. <h3>Methods</h3> Two patients with clinical OA having Heberden's nodes in their distal interphalangeal (DIP) joint at clinical presentation were imaged with conventional x-ray and high resolution MRI to ascertain the extent of joint involvement. Gelatinous material from the synovial cysts was extruded and plastic-adherent cells were expanded in MSC conditions and characterised phenotypically and functionally utilising trilineage differentiation assays. Mesenchymal related gene expression was studied using a Custom Taqman Low Density Array (69 Genes) to determine the underlying origin and molecular profile of the cells. <h3>Results</h3> Imaging showed that one case had excellent articular cartilage preservation but had osteophyte formation, whilst the other case had more extensive joint damage. The HN material formed MSC-like colonies, displayed an MSC phenotype being negative for CD14, CD19, CD31, CD34, CD45 and HLADR, and positive for CD29, CD44, CD73, CD90, CD105 and CD166. Functionally these cells exhibited osteogenic, adipogenic and chondrogenic lineage differentiation. Gene cluster analysis showed that HN-MSCs were more closely related to synovial fluid (SF-) than to bone marrow (BM-MSCs) with much higher expression of SFRP4 (Secreted Frizzled-Related Protein 4), a newly identified synovium/SF-MSC marker [2]. <h3>Conclusions</h3> This is the first description of a resident population of MSCs in a small joint in which, we show their presence in acute Heberden's nodes. The presence of these MSCs even in cases where there is good preservation of articular cartilage indicates Heberden's node stem cell activity may be a key early event in hand OA pathogenesis. <h3>References</h3> Kellgren JH, Moore R. Generalized osteoarthritis and Heberden's nodes. Br Med J 1952;1:181-7. Sekiya I, Ojima Ml. Human mesenchymal stem cells in synovial fluid increase in the knee with degenerated cartilage and osteoarthritis. J Orthop Res 2011. Epub 2011/12/08. <h3>Disclosure of Interest</h3> None Declared
OP0101-HPR In Patients with Hand OA there is no Evidence that a Booster Session after Multidisciplinary Treatment is Effective; Results of a Randomised Controlled Trial
Authors: C. Van Den Ende, M. Stukstette, T. Hoogeboom, W. Noort, J. W. Bijlsma, J. Dekker
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In a systematic review on the long-term effectiveness of exercise therapy in patients with OA of the knee and/or hip it was suggested that additional booster sessions positively influence the long term effectiveness on pain and limitations in activities (1). The effectiveness of a booster session after non-pharmacological treatment in patients with hand OA utilizing a randomised design has never been investigated. <h3>Objectives</h3> To examine the effect of a single booster session on pain and limitations in activities in patients with hand OA on the long term. <h3>Methods</h3> Design: randomised controlled trial, nested within cohort study. Included were patients with hand OA according to the clinical ACR classification criteria of whom complaints due to osteoarthritis of hands were the most or second most important problem. All patients received 4 group-based treatment sessions supervised by a specialized nurse and an occupational therapist. Six months after the start of the multidisciplinary treatment program patients were randomly assigned to the experimental (booster-session) or control group (wait and see). Primary outcome measures were the AUSCAN subscale limitations in activities and the OARSI responder criteria one year after the start of multidisciplinary treatment. Secondary outcome measures included measures for self-efficacy, grip strength and joint mobility. <h3>Results</h3> 147 patients were included in this studywith a mean (SD) age of 59 (8) years, 84% female. The score on the AUSCAN limitations of activities scale improved from mean (SD) 20.9 (6.2) at baseline to 19.1 (7.7) at one year follow up and from 19.1 (7.2) to 18.0 (8.2) in the experimental and control group, respectively. Between group difference in the AUSCAN limitations in activities subscale at one year follow up was -0.3 (-2.4; 1.7). About one fifth of participants could be classified as a responder (22% versus 23% of participants in the experimental group and the control group, respectively). There were no differences between groups in any of the secondary outcome measures at twelve months follow-up. <h3>Conclusions</h3> The long term improvements after a multidisciplinary treatment in hand OA are small. A single booster session after six months has no additional value. <h3>References</h3> Pisters MF, Veenhof C, van Meeteren NL, Ostelo RW, de Bakker DH, Schellevis FG, Dekker J. Long-term effectiveness of exercise therapy in patients with osteoarthritis of the hip or knee: a systematic review. Arthritis Rheum 2007;57:1245-53 <h3>Disclosure of Interest</h3> None Declared
Abstract 1765: Preclinical optimization of the Chk1/2 inhibitor AZD7762 in combination with gemcitabine in pancreatic cancer
Authors: Leslie A. Parsels, Meredith A. Morgan, Daria M. Tanska, Joshua D. Parsels, Mary A. Davis, Maria C. Hassan, Sankari Arumugarajah, Linda Hylander-Gans, Deborah Morosini, Lili Zhao, Diane M. Simeone, Christine E. Canman, Daniel P. Normolle, Sonya D. Zabludoff, Theodore S. Lawrence, Jonathan Maybaum
Journal: Cancer Research (2010)

Abstract Pancreatic cancer remains among the most lethal cancers with an overall 5-year survival of less than 5%. Chk1 inhibition has emerged as a promising approach to sensitize pancreatic cancer to gemcitabine (Gem), the current standard therapy for both local control and metastatic disease. Here, we characterized the ability of AZD7762, a small molecule Chk1/2 inhibitor currently in Phase I trials, to sensitize pancreatic cancer cells to Gem both in vitro and in vivo. We first evaluated the in vitro schedule-dependence of AZD7762-mediated Gem sensitization by clonogenic assay. We found that AZD7762 effectively sensitized pancreatic cancer cell lines to Gem-induced loss of clonogenicity, with shifts in IC50 from 3- to 38-fold, compared to cells treated with Gem alone. At low concentrations of Gem (≤IC50), AZD7762 was most effective when present during Gem treatment. At higher concentrations of Gem, however, giving AZD7762 24 h after Gem resulted in the greatest sensitization. We next assessed the molecular mechanisms of AZD7762-mediated chemosensitization in one of these cell lines, MiaPaCa2, by immunoblot, flow cytometry and immunofluorescent staining. Gemcitabine sensitization was associated with inhibition of Chk1, rather than Chk2 and abrogation of the S-M and G2-M checkpoints. Despite checkpoint abrogation, we found that Gem/AZD7762-treated cells were unable to exit S-phase and, over time, AZD7762 inhibited DNA synthesis, as measured by BrdUrd incorporation. This inhibition was associated with pan γ-H2AX staining in Gem-treated cells, in addition to disruption of Rad51 foci and inhibition of homologous recombination repair activity. We next evaluated the effects of AZD7762 in two different human pancreatic cancer xenograft models; MiaPaCa2, and a patient-derived early passage pancreatic cancer xenograft, EPX-J. AZD7762 had anti-tumor activity both as a single agent, and in combination with Gem in both MiaPaCa2 and EPX-J, with average times to tumor doubling of 37 and 49 days, respectively, in tumors treated with both Gem/AZD7762, compared to 18 and 29 days for tumors treated with Gem alone (*p≤0.05). Chk1 inhibition, as determined by S296- and S345-Chk1 phosphorylation status, correlated with in vivo response. Finally, we found increased S345-Chk1 phosphorylation in normal tissues from mice treated with Gem/AZD7762, suggesting this may be a useful surrogate marker for AZD7762 activity in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1765.
PWE-006 Nicorandil Usage Is Associated With Complicated Diverticulitis
Authors: A O’Brien, A Young, F Duthie
Journal: Gut (2014)

<h3>Introduction</h3> Nicorandil is widely used in the treatment of ischaemic heart disease, but over the last ten years there has been a growing body of literature reporting the association between nicorandil and ulceration of the gastrointestinal tract. In the setting of diverticulosis/diverticulitis, any superimposed ulceration may lead to significant complications, but data on whether or not nicorandil contributes to this is scanty and limited to one study which only investigated intestinal fistulae.<sup>1</sup> Our aim is to identify if any potential association between all forms of complicated diverticulitis and nicorandil exists. <h3>Methods</h3> We reviewed 100 reports of colonic resections with diverticular disease received in a single institution over a 6 month period (from June 2013 to January 2014) and divided them into those with complicated diverticulitis (defined as active diverticulitis in combination with perforation, fistulation, abscess formation or structuring)<sup>2</sup> and those with uncomplicated diverticulitis or uninflamed diverticulosis. The age, sex, surgical indication and use of nicorandil were recorded for both groups. <h3>Results</h3> 51 patients had complicated diverticulitis and 45 had uncomplicated diverticulitis or diverticular disease (7 diverticulosis only, 3 diverticulitis, 4 diverticular stricture/fibrosis, 3 ischaemia + diverticulosis, 24 colorectal cancer + diverticulosis, 3 Crohn’s disease + diverticulosis, 1 prolapse + diverticulosis, 1 ovarian cancer + diverticulosis). 4 were excluded because no drug history was available. The age range in the complicated diverticulitis group was 26 to 89 years with a mean age of 62 years with a male to female ratio of 23:28. The age range in the uncomplicated group was 46 to 89 years with a mean age of 72 years with a male to female ratio of 6:9. In the complicated diverticulitis disease group, 6 patients (12%) were on nicorandil therapy, compared to 0 in the other group, a significant difference (p = 0.019, Fisher’s exact Test). The use of nicorandil was not stated on any of the pathology request forms. It was raised as a possible contributing factor in only one pathology report. <h3>Conclusion</h3> We have shown that there is an association between nicorandil use and complicated diverticulitis. In addition, we have also demonstrated that nicorandil-associated perforation, fistulation and abscess formation in diverticular disease is under reported. <h3>References</h3> McDaid J, Reichl C, Hamzah I, Fitter S, Harbach L, Savage AP. Diverticular fistulation is associated with nicorandil usage. <i>Ann R Coll Surg Engl.</i> 2010;92(6):463–5 Commissioning guide: Colonic diverticular disease. <i>The Royal College of Surgeons of England.</i> 2013 (available at http://www.rcseng.ac.uk/healthcare-bodies/docs/CommissioningGuideforColonicdiverticulardiseaseouttoconsultationfrom27November201310January2014.pdf accessed 24/1/2014) <h3>Disclosure of Interest</h3> None Declared.
606 METFORMIN PREVENTS OVERT HEPATIC ENCEPHALOPATHY (HE) IN CIRRHOTICS: A RETROSPECTIVE OBSERVATIONAL STUDY
Authors: J. Ampuero, M. Maraver, R. Aparcero, C. Cano, A. Rojas, M. Millán, R. Gallego-Durán, I. Camacho, B. Figueruela, E. Suárez, E. Hoyas, M. Romero-Gómez
Journal: Journal of Hepatology (2012)
Comt Genotype and Patients' Recognition of Pain Reduction are Predictive Markers for the Response to Morphine Treatment
Authors: H. Matsuoka, T. Arao, C. Makimura, K. Matsumoto, H. Kimura, C.K. Imamura, Y. Tanigawara, K. Nishio, K. Nakagawa
Journal: Annals of Oncology (2013)
FRI0594-HPR Pain, function and quality of life in different degrees of knee osteoarthritis: is there a difference?
Authors: S. Meneses, S. Dreyer, P. Alfredo, A. P. Marques
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Osteoarthritis (OA) is a prevalent disease associated with significant morbidity and is one of most common causes of pain, functional limitations and dependence, possibly compromising the quality of life. <h3>Objectives</h3> To compare pain, function and quality of life in different degrees of knee OA. <h3>Methods</h3> The study included 100 patients of both sexes, aged between 50 and 75 years and grade 2, 3 or 4 of OA by Kellgren and Lawrence’s classification<sup>1</sup>. The patients were divided into three groups according to the degree of knee OA: Group G2 - patients with grade 2 (n = 35), group G3 - patients with grade 3 (n = 40) and G4 group - patients with grade 4 (n = 25). Pain intensity was assessed by visual analog scale (VAS), quality of life by the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and functionality by the Lequesne Functional Questionnaire. Statistical analysis was performed using one way ANOVA with Holm-Sidak method for intergroup analysis and the Kruskal-Wallis for non-parametric values. The significance level was α=0.05. <h3>Results</h3> The age and body mass index were similar between groups. For the WOMAC function subscale, WOMAC total score and LEQUESNE there was a significant difference between G2 and G3 (p &lt;0.05) as well as for the functionality between G2 and G4 (p = 0.004). <h3>Image/graph</h3> <h3>Conclusions</h3> Patients with grade 3 of knee osteoarthritis had a poorer quality of life and function compared to patients with grade 2 and 4. There was no significant difference for pain and for WOMAC pain and stiffness subscales in the three groups. <h3>References</h3> Kellgren JH, Lawrence JS. Radiological assessment of osteoarthritis. Ann Rheum Dis. 1957;16(4):494-501. <h3>Acknowledgements</h3> Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP <h3>Disclosure of Interest</h3> None Declared
Abstract 2036: Forced activation of Cdk1 via Wee-1 inhibition impairs homologous recombination in breast cancer cells
Authors: Marcel A. Van Vugt, Malgosia Krajewska, Yvette Bisselink, Renee I. Seinstra, Herman H. Sillje, Elisabeth G. de Vries
Journal: Cancer Research (2012)

Abstract In response to DNA breaks, the so-called ‘DNA damage response’ provokes a cell cycle arrest to facilitate DNA repair. Recent findings have indicated that cells can respond to DNA damage throughout the cell cycle, except during mitosis. Specifically, various mitotic kinases, including Cdk1, Aurora A and Plk1, were shown to inactivate key DNA damage checkpoint proteins, including 53BP1. As a consequence, aberrant expression of mitotic kinases during interphase might modulate cellular responses to DNA damage. In this study we analyzed how aberrant activation of Cdk1 affects the cellular responses to DNA damage in breast cancer cells. We used Wee1 inhibition to enforce Cdk1 activation, which did not cause cytotoxicity in non-transformed cells. In contrast, Wee1 inhibition accelerated mitotic entry and caused radio-sensitization in p53-defective, but not p53-proficient breast cancer cells. Interestingly, we could show that Wee1 inhibition leads to elevation of Cdk1 activity in interphase breast cancer cells. When we subsequently analyzed DNA damage responses in cells with forced Cdk1 activation, we observed a marked reduction of the repair protein 53BP1 at the sites of DNA damage. In addition, Wee1 inhibition resulted in an increase in the number of γ-H2AX foci after irradiation, indicative of defective DNA repair. Indeed, when DNA repair was analyzed using in vivo endonuclease-induced recombination assays, compromised DNA repair after Wee1 inhibition was confirmed. Taken together, our data show that Wee1 inhibition leads to forced Cdk1 activation in interphase cells and that this interferes with normal DNA damage responses. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2036. doi:1538-7445.AM2012-2036
Unusual Cause of Unilateral Pulmonary Uptake on Stress Tl-201 Imaging
Authors: P. TODD MAKLER, LOUIS PAPA
Journal: Clinical Nuclear Medicine (1996)

Images of the chest obtained during a stress Tl-201 study revealed uptake in the right chest. Diagnostic possibilities included unilateral pulmonary uptake, a high riding liver, or uptake in the chest wall (or breast). The short axis slices of the left ventricle showed an unusual pattern with decreased activity in the lateral wall of the heart. The chest x-ray explained the findings by demonstrating evidence of a left pneumonectomy.
Stat Bite: Top 5 Cancers for Females and Males in the U.S.
Authors: L. A.G. Ries
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite: Top 5 Cancers for Females and Males in the U.S. Get access Lynn A.G. Ries, M.S. Lynn A.G. Ries, M.S. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 12, 21 June 1995, Page 867, https://doi.org/10.1093/jnci/87.12.867 Published: 21 June 1995
Treatment Advances Overdue for Small Cell Lung Cancer
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Treatment Advances Overdue for Small Cell Lung Cancer Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 12, 16 June 1993, Pages 938–939, https://doi.org/10.1093/jnci/85.12.938 Published: 16 June 1993
EVALUATION OF ELECTRONIC ALERTS TO IDENTIFY PATIENTS FOR ADVANCED HEART FAILURE THERAPIES: LET’S FIND THEM SOONER
Authors: Deborah Budge, Jose Benuzillo, R. Scott Evans, Jennifer Nixon, Rami Alharethi, James Lloyd, Kismet Rasmusson, Colleen Roberts, Benjamin Horne, Donald Lappe
Journal: Journal of the American College of Cardiology (2015)