tbuckley/cabot-search huggingface dataset:
Agitated psychotic depression associated with severe hypomanic episodes: a rare syndrome
Authors: J M Himmelhoch, P Coble, K J Kupfer, J Ingenito
Journal: American Journal of Psychiatry (1976)

The authors present detailed clinical and follow-up data on 12 patients with agitated psychotic depressions who developed serious hypomanic or manic episodes. In six patients, each type of affective episode seemed to merge into the others, while in the other patients there was always a clear temporal distinction between each type of episode. The authors suggest that the older ages of their patients may have contributed to the syndrome. They also offer several possible theoretical explanations: the patients 1) had mixed affective states and were trapped in the "switch" state from depression to mania, 2) inherited both unipolar and bipolar diseases, 3) represent a subgroup of bipolar patients, and 4) were schizoaffective.
Immunologic and Clinical Responses To a CD20-Targeted Immunocytokine, DI-Leu16-IL2, In Relapsed Non-Hodgkin Lymphoma
Authors: Ryotaro Nakamura, Robert Chen, Joycelynne Palmer, Karl Gaal, Auayporn Nademanee, Leslie Popplewell, James E. Talmadge, Stephen Gillies, David Colcher, Stephen J. Forman, Andrew Raubitschek
Journal: Blood (2013)
Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Authors: Ashwini Kumar Sharma, Roland Eils, Rainer König
Journal: Cancer Research (2016)

Somatic copy number alterations frequently occur in the cancer genome affecting not only oncogenic or tumor suppressive genes, but also passenger and potential codriver genes. An intrinsic feature resulting from such genomic perturbations is the deregulation in the metabolism of tumor cells. In this study, we have shown that metabolic and cancer-causing genes are unexpectedly often proximally positioned in the chromosome and share loci with coaltered copy numbers across multiple cancers (19 cancer types from The Cancer Genome Atlas). We have developed an analysis pipeline, Identification of Metabolic Cancer Genes (iMetCG), to infer the functional impact on metabolic remodeling from such coamplifications and codeletions and delineate genes driving cancer metabolism from those that are neutral. Using our identified metabolic genes, we were able to classify tumors based on their tissue and developmental origins. These metabolic genes were similar to known cancer genes in terms of their network connectivity, isoform frequency, and evolutionary features. We further validated these identified metabolic genes by (i) using gene essentiality data from several tumor cell lines, (ii) showing that these identified metabolic genes are strong indicators for patient survival, and (iii) observing a significant overlap between our identified metabolic genes and known cancer-metabolic genes. Our analyses revealed a hitherto unknown generic mechanism for large-scale metabolic reprogramming in cancer cells based on linear gene proximities between cancer-causing and -metabolic genes. We have identified 119 new metabolic cancer genes likely to be involved in rewiring cancer cell metabolism. Cancer Res; 76(14); 4058-67. ©2016 AACR.
The Benefit of SPECT When Added to Planar Scintigraphy in Patients With Bone Metastases in the Spine
Authors: IRENA SEDONJA, NATAŠA V. BUDIHNA
Journal: Clinical Nuclear Medicine (1999)

Purpose: This study compared the efficiency of SPECT with planar bone scans in differentiating malignant from benign lesions and in detecting metastases to the spine. Methods: Planar scintigraphy and SPECT were performed in 37 patients with low back pain without known malignancy and in 38 patients with confirmed malignancy. The type, location, and intensity of tracer accumulation were compared on the planar and SPECT scans. The malignant or benign nature of lesions was proved by radiologic methods, histologic findings, 6 month follow-up, or all of these. Results: More metastases were detected by SPECT (SPECT, 58 of 64; planar, 42 of 64; P < 0.01). In three of seven patients with known malignancy who had a normal result of planar scan, only SPECT detected metastases. Fifty-nine metastases were radiologically mainly osteolytic, one was osteoblastic and four were mixed. Most lesions showed increased radioactivity (40 of 42 on planar scans vs. 45 of 58 on SPECT) and 2 of 42 (5%) vs. 12 of 58 (21%) were cold with marginally increased uptake. One of 58 metastases was a cold lesion seen on SPECT only. Lesions were more often malignant than benign when seen on SPECT in a pedicle (n = 5; malignant = 3, benign = 2), in the body and pedicle (n = 22; malignant = 14, benign = 8), within the vertebral body (n = 5; malignant = 4, benign = 1) and in the whole vertebra (n = 6; malignant = 4, benign = 2). The lesion to background ratio was higher on SPECT than on planar scans (SPECT, 2.26; planar scans, 1.86; P < 0.05 in malignant lesions). Conclusions: SPECT of the spine improved the diagnostic accuracy of bone scans when added to a planar scan in patients with known malignancy and clinical suspicion of spinal metastases when the planar scan was borderline abnormal. It helps in differentiating between benign and malignant lesions of the spine.
Immune Response to Gross Virus-Induced Lymphoma: Comparison of Two In Vitro Assays of Cell-Mediated Immunity
Authors: Peter W. Wright, Manuel Ortiz de Landazuri, Ronald B. Herberman
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Immune Response to Gross Virus-Induced Lymphoma: Comparison of Two In Vitro Assays of Cell-Mediated Immunity Get access Peter W. Wright, Peter W. Wright Laboratory of Cell Biology, National Cancer Institute,2Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Manuel Ortiz de Landazuri, Manuel Ortiz de Landazuri Laboratory of Cell Biology, National Cancer Institute,2Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar Ronald B. Herberman Ronald B. Herberman Laboratory of Cell Biology, National Cancer Institute,2Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 50, Issue 4, April 1973, Pages 947–954, https://doi.org/10.1093/jnci/50.4.947 Published: 01 April 1973 Article history Received: 31 July 1972 Accepted: 22 November 1972 Published: 01 April 1973
New epidemiological features of meningococcal disease in Belgium
Authors: F Carion, M van Looveren, H Goossens
Journal: Eurosurveillance (1997)

SCIENTIFIC EDITOR In Belgium, after the epidemic of the early 1970s caused by Neisseria meningitidis B:2b:P1.2 (highest incidences in 1971 and 1972 with 5 cases per 100 000 population per year), the incidence of meningococcal disease fell to normal inter
Diffuse Multinodular Hepatic Steatosis of Metastatic Appearance
Authors: P. Amoyal, P. Bauret, P. Bories, H. Michel
Journal: Endoscopy (1989)

Atteinte des 2 lobes hepatiques chez une femme obese (63 kg pour 1,50 m). Revue de 6 cas decrits recemment dans la litterature
Talking with patients about dying.
Authors: Kevin P Weinfurt, Scott Y Kim, Neal J Meropol
Journal: New England Journal of Medicine (2013)

n engl j med 368;5 nejm.org january 31, 2013 479 merely the natural time course of the disorder is still unclear. Our study was the first trial of radiofrequency ablation in patients with atrial fibrillation with 2 years of follow-up. We are currently planning to coordinate a supplementary 5-year follow-up that will include data from Holter monitoring and recording of intercurrent radiofrequency ablation procedures after the 2-year follow-up and the ongoing use of antiarrhythmic medications. We are also analyzing the cost-effectiveness of the two strategies. Jens Cosedis Nielsen, M.D., D.M.Sc. Aarhus University Hospital Aarhus, Denmark jenniels@rm.dk
Abstract P5-09-12: The importance of education for adherence to mammographic screening in the Brazilian public health services
Authors: EC Blanco, IM Ribeiro, CCP Nascimento, CA da Silva, CF Abrah㯀, MM Borges
Journal: Cancer Research (2016)

Abstract Introduction: A third of the registration of new cases of breast cancer in Brazil corresponds to locally advanced or late diagnosed disease. The benefits of screening in this sense become evident and measurable in terms of their temporal extent and adherence of the target population to its recommendations. Unlike the organized mammographic screening where there is call, breast health education, monitoring and enforcement of the intervals between examinations, in the opportunistic model, individuals are subject to the recommendations from the spontaneous demand by health services. Objective: To determine the influence of education in breast cancer for adherence to mammographic screening in brazilian public health services. Methods: This is a cross-sectional, descriptive and comparative study between two groups of women with (group A, n=136) and without (group B, n=128) knowledge about breast cancer, who appeared in the Center of Detection, Diagnosis and Monitoring (CDDM) for organized screening. For this were interviewed 264 women in relation to the realization of previous mammograms in the last three years. The repetition of examinations, respecting the range of 24 months was defined as criteria to classify participants in adherent or not to screening. Results: Both groups of women had a similar mean age (50.2 ± 9.2 and 49.5 ± 9.5 years; p&amp;gt;0.05). Of the respondents, 77.2% (n=204) reported mammographic screening before joining the CDDS, however highest proportion was registered in group A (64.8%). Sixty women denied conducting prior mammography with predominance in the Group B (93.4% vs 6.6%, p&amp;lt;0.05). One hundred forty-four women were adherent to screening, 90.2% (n=130) of these belonged to group A. The remaining variables (education, occupation, family income, distance between place of residence and mammography center and personal / family history of breast cancer) were not associated with adherence to screening (p&amp;gt;0.05). Conclusion: The decrease in the adherence to conducting periodic mammography observed in group B reflects the opportunistic character of the screening in the country, where it loses the chance to sensitize women through education to improve their effective adhesion. Acknowledgements to the Brazilian Ministry of Health for their support to the study. Citation Format: Blanco EC, Ribeiro IM, Nascimento CCP, da Silva CA, Abrah㯀 CF, Borges MM. The importance of education for adherence to mammographic screening in the Brazilian public health services. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-09-12.
Audiotape playback as a technique in the treatment of schizophrenic patients
Authors: S L Satel, W H Sledge
Journal: American Journal of Psychiatry (1989)

The authors report on the use of playing back audiotaped portions of the speech of two schizophrenic patients during psychotherapy. They believe that this audiotape replay was instrumental in organizing the patients' thoughts and spoken communications and that it might also have facilitated the patients' participation in psychotherapy. The usefulness of this strategy is illustrated with clinical material.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1965)

COMMITTEE ON MATERNAL WELFAREFetal Death Due to Erythroblastosis FetalisAt the age of seven and a half hours a first-born infant died of erythroblastosis fetalis, thus probably depriving the young mother of her only chance to have a baby sired by this husband.Denying prior blood transfusions, plasma infusions, whole-blood injections, and prior pregnancies, this normal primigrivida was found at five months to have Group O, Rh-negative blood, with an anti-Rh titer of 128 by the indirect Coombs test. Expert consultants urged the obstetrician to watch the pregnancy very carefully, with repeated titrations at weekly intervals, but a second . . .
Cerebral Palsy
Authors: Eric Denhoff, Victor N. Smirnoff, Raymond H. Holden
Journal: New England Journal of Medicine (1951)

PsychologyDuring the past five years a growing interest has been shown in the psychologic appraisal of patients with cerebral palsy. Psychologic studies include intellectual evaluation, projective technics and experiments in perception and conceptual thinking. Intellectual Evaluation The incidence of mental deficiency in cerebral palsy has been estimated differently by various authors. Mclntire123 has reported an incidence of mental deficiency of 18 per cent; Phelps124 reports an incidence of 28 per cent; and other authors have found mental deficiency in 45 to SO per cent of their cases.125 , 126 Thus it appears that retardation in children with cerebral palsy may be . . .
Circulating Free Dna and Plasma Kras Mutations in Metastatic Colorectal Cancer Patients Treated with Bi-Weekly Cetuximab and Irinotecan
Authors: K.G. Spindler, N. Pallisgaard, K. Skovgaard, R. Andersen, H. Hendel, M. Yilmaz, P. Pfeiffer, D.L. Nielsen, J. Johansen, E. Hoegdall, A. Jakobsen, B. Vittrup
Journal: Annals of Oncology (2014)
Abstract P3-07-19: Progesterone receptor positivity is an independent predictor of long-term benefit from adjuvant tamoxifen treatment of estrogen receptor positive breast cancer
Authors: H Fohlin, A Nordenskjöld, T Fornander, B Löfdahl, L Skoog, O Stål
Journal: Cancer Research (2016)

Abstract Introduction:The expression of estrogen receptor (ER) and progesterone receptor (PgR) predicts the response to endocrine therapy of breast cancer. Nearly all PgR positive tumors are also ER positive. The independent predictive information of PgR has been questioned after an overview by the EBCTCG. However, the studies in the overview were performed before modern PgR immunohistochemistry (IHC) was developed. Purpose: We aim to investigate the independent predictive value of PgR determined by IHC in ER positive tumors. Materials and methods: Between 1976 and 1990 the Stockholm Breast Cancer Study Group conducted a randomized trial comparing adjuvant tamoxifen versus control. We evaluated 618 patients with ER-positive "low-risk" breast cancer ( tumor size≤ 30 mm and lymph node-negative) for whom PgR was determined by immunohistochemistry. The median follow-up was 17 years. Hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using the Cox's proportional hazards model. Results: Patients with ER+/PgR+ tumors receiving tamoxifen had a reduced recurrence risk compared with those who were not treated with tamoxifen (HR= 0.40, 95% CI 0.27 – 0.59, p&amp;lt; 0.001). For patients with ER+/PgR- tumors the difference between tamoxifen vs. no tamoxifen treatment was not statistically significant (HR= 0.88, 95% CI 0.51 – 1.52, p= 0.65). P for interaction between the groups was 0.02. Tam vs. controlPgR (IHC)HR (95% CI)P valueP for interactionRecurrence-free survival≥ 10 %0.40 (0.27 - 0.59)&amp;lt; 0.0010.02 &amp;lt; 10 %0.88 (0.51 - 1.52)0.65 Distant recurrence-free survival≥ 10 %0.41 (0.25 - 0.65)&amp;lt; 0.0010.08 &amp;lt; 10 %0.80 (0.44 - 1.47)0.47 Breast-cancer specific survival≥ 10 %0.35 (0.21 - 0.60)&amp;lt; 0.0010.11 &amp;lt; 10 %0.70 (0.37 - 1.33)0.28 Conclusion: Our results indicate that the PgR expression adds predictive value to the ER expression regarding benefit from tamoxifen treatment. Citation Format: Fohlin H, Nordenskjöld A, Fornander T, Löfdahl B, Skoog L, Stål O. Progesterone receptor positivity is an independent predictor of long-term benefit from adjuvant tamoxifen treatment of estrogen receptor positive breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-07-19.
Psychiatry and folk healing: a dichotomy?
Authors: P Ruiz, J Langrod
Journal: American Journal of Psychiatry (1976)

A mental health center's experience with folk healers in a Hispanic urban ghetto revealed a culturally accepted belief system based on a body of empirical knowledge that helps its members to cope with distress. The authors suggest that including folk healers as team members in the delivery of mental health services is a valuable contribution to psychiatry.
Clinical predictors of residual breast disease after primary induction chemotherapy
Authors: P. F. Escobar, R. Patrick, L. Rybicki, S. Grundfest-Broniatowski, J. Kim, J. Crowe
Journal: Journal of Clinical Oncology (2004)

688 Background: The purpose of this study was to determine if pre-operative tumor characteristics can predict which patients are likely to have residual infiltrating breast cancer (RIBC) after undergoing primary induction chemotherapy. Methods: Data were collected prospectively for 85 patients with locally advanced breast cancer who underwent primary induction chemotherapy followed by surgery. Variables included age at diagnosis, hormone receptor status, pre-operative taxane, and cTNM tumor size, axillary node status, and stage. Recursive partitioning analysis was used to determine cutpoints in age or cTNM size that predict residual breast disease. The Chi-square test was used to identify significant univariable correlates of RIBC. A P-value of less than 0.05 was considered significant. Results: Age at diagnosis, cTNM axillary node status, and stage predicted RIBC in the pathologic specimen. RIBC was identified in 100% (n=19) of the surgical specimens of patients > 56 years of age compared to 79% (n=52 of 66) of patients ≤ 56 years (P=0.028). cTNM size, although not clinically significant (P=0.07), suggested increasing tumor size may correlate with RIBC: 72% (n=21 of 29) of tumors with clinical measurement of 1–6 cm had RIBC, compared to 88% (n=36 of 41) of those measuring 7–12 cm and 100% (n=11) of those measuring 13–20 cm. cTNM node status was available for 70 patients: 57% (n=4 of 7) of cN0 patients compared to 87% (n=55 of 63) of cN1 patients had RIBC (P=0.038). Higher cTNM stage predicted RIBC (P=0.026): 65% (n=11 of 17) of patients with cTNM stage IIA or IIB had RIBC compared to 80% (n=28 of 35) cTNM stage IIIA, 100% (n=17) of cTNM stage IIIB, and 94% (n=15 of 16) TNM stage IV. Hormone receptor status (P=0.76) and inclusion of a taxane derivative in the pre-operative chemotherapy course (P=0.39) were not significant predictors of residual disease. Conclusions: Patients diagnosed at more than 56 years of age, or who were cTNM node positive, or cTNM stage IIIB or IV were most likely to have RIBC. A trend was established that suggested cTNM size might predict RIBC. Neither hormone receptor status nor the addition of a taxane derivative to the induction chemotherapy regimen predicted RIBC. No significant financial relationships to disclose.
Clinical issues in the assessment of competency
Authors: P S Appelbaum, L H Roth
Journal: American Journal of Psychiatry (1981)

The evaluation of a patient's competency to consent to treatment, regardless of the test of competency used, can be substantially affected by a number of clinical factors. The authors point out that, in assessing competency, the clinician must consider 1) psychodynamic elements of the patient's personality, 2) the accuracy of the historical information conveyed by the patient, 3) the accuracy and completeness of the information disclosed to the patient, 4) the stability of the patient's mental status over time, and 5) the effect of the setting in which consent is obtained. Inattention to these factors can lead to errors in assessment of competency that can have important implications for patient care.
Food-borne viruses in Europe network report: the norovirus GII.4 2006b (for US named Minerva-like, for Japan Kobe034-like, for UK V6) variant now dominant in early seasonal surveillance
Authors: J Siebenga, A Kroneman, H Vennema, E Duizer, M Koopmans
Journal: Eurosurveillance (2008)

Binary file ES_Abstracts_Final_ECDC.txt matches
Do Surgeons or Does Hospital Economics Ultimately Decide Operative Approach?—Reply
Authors: Jason D. Wright, Dawn L. Hershman
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Challenge of Locally Persistent Prostate Cancer: An Unresolved Clinical Dilemma
Authors: Christopher J. Logothetis
Journal: Journal of Clinical Oncology (2002)

Article Tools EDITORIALS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.15.3187 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12149287 Challenge of Locally Persistent Prostate Cancer: An Unresolved Clinical Dilemma Christopher J. LogothetisxChristopher J. LogothetisSearch for articles by this author Show More University of Texas Health Science Center, San Antonio, TX https://doi.org/10.1200/JCO.2002.20.15.3187 Full Text PDF Figures and Tables "Challenge of Locally Persistent Prostate Cancer: An Unresolved Clinical Dilemma." Journal of Clinical Oncology, 20(15), p. 3187© 2002 by American Society of Clinical Oncology