tbuckley/cabot-search huggingface dataset:
Indications of Involvement of the Reticuloendothelial System in Alterations of Iron Metabolism Produced by Tumor Extracts
Authors: Ralph F. Kampschmidt, West A. Clabaugh
Journal: JNCI Journal of the National Cancer Institute (1960)

Small, repeated, subcutaneous injections of an extract of the Walker carcinosarcoma 256 into normal rats maintained liver and kidney catalase activity and plasma-iron concentration at the low level usually found in tumor-bearing animals. These extracts also stimulated the phagocytic activity of the reticuloendothelial system (RES). Zymosan, a known stimulator of the RES, produced many of the same changes as those found when tumor extracts were administered to normal animals. The possible participation of the RES in the changes evoked by tumor extracts is discussed.
Treatment of Chronic Functional Mitral Valve Regurgitation With a Percutaneous Annuloplasty System
Authors: Georg Nickenig, Robert Schueler, Antonio Dager, Pedro Martinez Clark, Alexandre Abizaid, Tomasz Siminiak, Pawel Buszman, Marcin Demkow, Adrian Ebner, Federico M. Asch, Christoph Hammerstingl
Journal: Journal of the American College of Cardiology (2016)
Case 41-1967
Authors: Guillermo C. Sanchez, Benjamin Castleman
Journal: New England Journal of Medicine (1967)

PRESENTATION OF CASEA sixty-eight-year-old woman entered the hospital because of pain in the abdomen.Five years previously recurrent attacks of diverticulitis had necessitated a transverse colostomy, subsequent resection of the sigmoid colon and later repair of a ventral hernia. She remained well thereafter until the day before entry, when she began to experience increasingly severe pain in the epigastrium and right upper quadrant of the abdomen, without nausea or vomiting. She noticed darkening of the urine but no change in the color of the stools.There was no history of melena, hematemesis, chest pain, dyspnea or orthopnea. For two . . .
Medicine, Monopoly, and the Premodern State — Early Clinical Trials
Authors: Alisha Rankin, Justin Rivest
Journal: New England Journal of Medicine (2016)

Interview with Dr. Alisha Rankin on the clinical trials and drug approval processes of the 16th through 18th centuries. (07:09)Download An examination of the use of clinical trials as a tool for the marketing and licensing of drugs in Europe from the 16th through the 18th centuries reveals a surprising history of governmental involvement in the certification of promising therapeutics.
Re: Francesco Piva, Matteo Santoni, Marina Scarpelli, et al's Letter to the Editor re: Daniel M. Geynisman. Anti-programmed Cell Death Protein 1 (PD-1) Antibody Nivolumab Leads to a Dramatic and Rapid Response in Papillary Renal Cell Carcinoma with Sarcomatoid and Rhabdoid Features. Eur Urol 2015;68:912–4
Authors: Juan Ruiz-Bañobre, Urbano Anido, Jorge García-González
Journal: European Urology (2016)
The fatal myth of death in the family
Authors: E M Pattison
Journal: American Journal of Psychiatry (1976)

The author hypothesizes that the observed pathogenic effects on a child of the death of a parent are the result of the family's culture-bound inability to integrate death as a natural part of the process of living. The family tries to deal with death by the avoidance mechanisms of myth and family mystification; it is this process which is pathogenic rather than the experience with death itself. To illustrate his thesis he presents the case history of a man who was fatally affected by the family myth and mystification process.
Prodromal symptoms in affective disorders
Authors: G A Fava, R Kellner
Journal: American Journal of Psychiatry (1991)

The aim of this paper was to review the clinical and conceptual implications of the studies investigating prodromal symptoms of mania, depression, and panic disorder.Twenty-four studies specifically addressing the issue of prodromal symptoms in mood and anxiety disorders were selected by computer search (Medline) and manual search of Index Medicus and the psychiatric literature.Most of the studies have described a prodromal phase in the development of mania, depression, and panic attacks.The appearance of prodromal symptoms may precede the full syndrome by weeks or months; if these symptoms are detected, recurrences of affective disorders (bipolar illness, unipolar depression, panic disorder) could be treated earlier and perhaps more effectively. DSM-III has emphasized the traditional clinical syndromes and cross-sectional descriptions. Appraisal of prodromal and residual phases may complement this approach. The longitudinal study of prodromes, the fully developed disorder, and residual states calls for an assessment of personality, neurotic traits, and their interaction in the evolution of affective disorders.
Influence of Isolation Perfusion with an Alkylating Agent on the Histopathology and Metastatic Propensity of Walker 256 Carcinoma
Authors: A E RODIN, F W TURNER, C M COUVES
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High prevalence of adenomatous colorectal polyps in young cancer survivors treated with abdominal radiation therapy: results of a prospective trial
Authors: Patricia E Daly, Sara Samiee, Maria Cino, Robert Gryfe, Aaron Pollett, Andrea Ng, Louis S Constine, David C Hodgson
Journal: Gut (2016)

<h3>Objective</h3> Cancer survivors treated with abdominal/pelvic radiation therapy (ART) have increased the risks of colorectal cancer (CRC), although evidence supporting early CRC screening for these patients is lacking. We sought to determine whether there is an elevated prevalence of adenomatous colorectal polyps in young survivors prior to the age when screening would be routinely recommended. <h3>Design</h3> We conducted a prospective study of early colonoscopic screening in cancer survivors aged 35–49 who had received ART ≥10 years previously. The planned sample size was based on prior studies reporting a prevalence of adenomatous polyps of approximately 20% among the average-risk population ≥50 years of age, in contrast to ≤10% among those average-risk people aged 40–50 years, for whom screening is not routinely recommended. <h3>Results</h3> Colonoscopy was performed in 54 survivors, at a median age of 45 years (range 36–49) and after median interval from radiation treatment of 19 years (10.6–43.5). Forty-nine polyps were detected in 24 patients, with 15 patients (27.8%; 95% CI 17.6% to 40.9%) having potentially precancerous polyps. Fifty-three per cent of polyps were within or at the edge of the prior ART fields. <h3>Conclusions</h3> Young survivors treated with ART have a polyp prevalence comparable with the average-risk population aged ≥50 years and substantially higher than previously reported for the average-risk population aged 40–50 years. These findings lend support to the early initiation of screening in these survivors. <h3>Clinical trial registration number</h3> NCT00982059; results.
Umbilical Cord Blood-Derived Mesenchymal Stromal Cells for Reducing Chronic Graft-Versus-Host Disease After Haploidentical Transplantation: Just Another Labor-Intensive Strategy, or Showing the Way?
Authors: Hillard M. Lazarus, Steven Z. Pavletic
Journal: Journal of Clinical Oncology (2016)

GVHD incidence from 49.0% (95% CI, 36.5 to 61.5) in control subjects compared with 27.4% (95% CI, 16.2 to 38.6) in those given MSCs; P 5 .021). Furthermore, none of the MSC-treated subjects developed severe lung chronic GVHD compared with seven of the control subjects (P 5 .047). The authors hypothesized that the repeated MSC infusions may have modulated the host immune system as recipients had more memory B cells and regulatory T cells along with an increase in the Th1:Th2 ratio. Because of the uniquely selective in vitro and in vivo immunosuppressive properties, the investigators chose to incorporate MSCs into allogeneic HCT trials. 7-10 In the past few decades, perhaps only the addition of antihuman T-lymphocyte immune globulin (ATG) included in the conditioning regimen demonstrated reduced incidence and severity of chronic GVHD. 11,12 For example, in the randomized
The Case for “Environment in All Policies”: Lessons from the “Health in All Policies” Approach in Public Health
Authors: Geoffrey R. Browne, Ian D. Rutherfurd
Journal: Environmental Health Perspectives (2016)

Background:Both public health, and the health of the natural environment, are affected by policy decisions made across portfolios as diverse as finance, planning, transport, housing, education, and agriculture. A response to the interdependent character of public health has been the "health in all policies" (HiAP) approach.Objectives:With reference to parallels between health and environment, this paper argues that lessons from HiAP are useful for creating a new integrated environmental management approach termed "environment in all polices" (EiAP).Discussion:This paper covers the theoretical foundations of HiAP, which is based on an understanding that health is strongly socially determined. The paper then highlights how lessons learned from HiAP's implementation in Finland, California, and South Australia might be applied to EiAP. It is too early to learn from evaluations of HiAP, but it is apparent that there is no single tool kit for its application. The properties that are likely to be necessary for an effective EiAP approach include a jurisdiction-specific approach, ongoing and strong leadership from a central agency, independent analysis, and a champion. We then apply these properties to Victoria (Australia) to demonstrate how EiAP might work.Conclusions:We encourage further exploration of the feasibility of EiAP as an approach that could make explicit the sometimes surprising environmental implications of a whole range of strategic policies.Citation:Browne GR, Rutherfurd ID. 2017. The case for "environment in all policies": lessons from the "health in all policies" approach in public health. Environ Health Perspect 125:149–154; http://dx.doi.org/10.1289/EHP294
A case of malignant lymphoma with testis involvement detected by Ga-67 scan.
Authors: SHIH-CHUAN TSAI, KHEE-SIANG CHAN, CHIA-HUNG KAO
Journal: Clinical Nuclear Medicine (2001)

From the Department of Nuclear Medicine,* Show Chwan Memorial Hospital, Changhua, Department of Family Medicine,† Kuang-Tien General Hospital, Taichung, and the Department of Nuclear Medicine,‡ Taichung Veterans General Hospital, Taichung, Taiwan Received for publication July 19, 2000. Accepted August 30, 2000. Reprint requests: Chia-Hung Kao, M.D., Department of Nuclear Medicine, Taichung Veterans General Hospital, 160 Taichung Harbor Road, Section 3, Taichung 40705, Taiwan.
Ulcerative and Granulomatous Colitis.
Authors: R H Marshak, A E Lindner
Journal: Annals of Internal Medicine (1974)

This needed and well-written book deals with the pathology, radiology, clinical picture and surgery of ulcerative and  colitis. Each section was written by an authority in the field. No similar treatise is available on the same subject. The approach throughout is comprehensive and yet practical, reflecting extensive personal experience, research, and thoughtful analysis. Also of interest is a historical review of the medical history of ulcerative colitis and its relatively recent differentiation from  colitis. The book is profusely illustrated, with the radiologic chapter approaching atlas format. The volume contains excellent tables and drawings. The quality of the radiographic reproductions is average. New material is presented in the extensive review chapter of surgery. It comprises about one-third of the book. It covers the subject completely with sections on indications, choice of operation, preoperative preparation and postoperative care, results of surgery, and long-term complications. The section on long-term management of the patient with an ileostomy was written together with H. Honesty. The literature review is extensive in almost all chapters and as recent as 1971. Less attention is given to the more recent literature concerning the overlapping spectrum of radiologic signs in the two diseases and some of the limitations of the differential diagnosis in histopathologic analysis and gross findings. [(1) Glotzer DJ, Gardner RC, Goldman H, et al: Comparative features and course of ulcerative and  colitis. N Engl J Med 282: 582-587, 12 Mar 1970. (2) Hoffmann DC: Crohn's colitis: a diagnostic dilemma. Aust NZ J Surg 40:157-162, Nov 1970. (3) Margulis AR: The overlapping spectrum of radiologic signs in chronic ulcerative colitis and Crohn's disease of the colon. Calif Med 119 :49-50, Nov 1973. (4) Schachter H, Goldstein MJ, Rappaport H, et al: Ulcerative and granulomatous colitis-validity of differential diagnostic criteria. A study of 100 patients treated by total colectomy. Ann Intern Med 72: 841-851, Jun 1970. (5) Stanley P, Fry IK, Dawson AM, et al: Radiological signs of ulcerative colitis and Crohn's disease of the colon. Clin Radiol22 :434-442, Oct 1971.] In summary, this comprehensive review by leading experts in their respective fields should be of great value to all physicians concerned with diagnosis and treatment of ulcerative and  colitis. H. JOACHIM BURHENNE, M.D.
Widespread dissemination of epidemic MRSA in German hospitals
Authors: W Witte, C Cuny, C Braulke, D Heuck, I Klare
Journal: Eurosurveillance (1997)

Strains of Staphylococcus aureusresistant to multiple antibiotics, including those resistant to methicillin (MRSA), present a major problem in the control of hospital acquired infections. Some strains show a definite capacity for spread once introduced in
Identifying multimodal signatures associated with symptom clusters: the example of the IMAGEMEND project
Authors: Sophia Frangou, Emanuel Schwarz, Andreas Meyer‐Lindenberg
Journal: World Psychiatry (2016)

technique for testing mechanistic hypothesis about (subjectspecific) pathophysiological processes is dynamic causal modelling.Cross-sectional studies have already indicated the potential of this modelling in the prediction of the onset of psychosis and also treatment responses 11 .In particular, frontoparietal connectivity during working memory processing was found to be progressively reduced from healthy controls to high-risk subjects further to first-episode psychosis, whereas this coupling returned to levels indistinguishable from controls in antipsychotic-treated first-episode patients.Useful clinical predictions have to be made at the single subject level.Although model-based computational approaches are promising, it has yet to be shown whether they allow individual decision-making.Another established tool for this purpose is the application of machine learning approaches.These approaches have been increasingly used to dissect different stages of psychosis using structural and functional imaging data.Using a support vector machine analysis with gray matter volumes, Koutsouleris et al 12 were able to separate psychosis converters from non-converters in two independent samples with an accuracy of 80%.A recent study has also indicated that the assessment of white matter integrity may predict treatment responses in firstepisode psychosis 13 .Along this line, an ongoing multicentre trial named Optimization of Treatment and Management of Schizophrenia in Europe (OPTiMiSE), conducted in antipsychotic na€ ıve patients with a first episode of schizophrenia or schizophreniform disorder, is testing whether MRI measures can be helpful to identify predictors of response to treatment.In conclusion, neuroimaging studies have improved our understanding of the neurobiological mechanisms underlying psychosis.However, underpowered, cross-sectional study designs without hypothesis-driven strategies have so far impeded the achievement of a neuroimaging-based prediction of psychosis onset.Although many challenges lie ahead, the field is now moving towards conducting large multicentre studies to overcome some of these limitations.Such collaborations, in combination with standardized clinical and analytical approaches, will be required to exploit the entire potential of neuroimaging and to ultimately evaluate its clinical utility for psychosis services.
BRCA1-Associated Protein 1 (BAP1) Immunohistochemical Expression as a Diagnostic Tool in Malignant Pleural Mesothelioma Classification: A Large Retrospective Study
Authors: Luisella Righi, Eleonora Duregon, Simona Vatrano, Stefania Izzo, Jessica Giorcelli, Milena Rondón-Lagos, Valeria Ascoli, Enrico Ruffini, Laura Ventura, Marco Volante, Mauro Papotti, Giorgio Vittorio Scagliotti
Journal: Journal of Thoracic Oncology (2016)
IHC versus FISH for the detection of ERG rearrangements in prostate cancer.
Authors: Ekaterina Pestova, Ying Zhang, William Barbanera, Kelly A. Kaiser-Walters, Jing Du, Ping Liu, Lela Buckingham, Tracey Colpitts
Journal: Journal of Clinical Oncology (2015)

102 Background: ERG rearrangements are present in about 50% of all prostatic adenocarcinomas (CaP). Using ERG break-apart fluorescence in situ hybridization (FISH) probes, several classes of ERG rearrangement patterns have been described: Edel, Esplit, and 2+Edel. Class ERG 2+Edel was reported to be associated with lethal disease and significantly worse clinical outcome in CaP, while prognostic significance of other classes of ERG rearrangements and of ERG protein expression remains controversial. In this study, we found that IHC cannot discriminate between various forms of ERG rearrangements including 2+Edel, while FISH can. Methods: Formalin fixed paraffin embedded (FFPE) histological specimens from 52 Radical Prostatectomy (RP) cases were used. FISH analysis was performed using Abbott Molecular dual-color break-apart probes for the 5' and 3' regions of the ERG gene. Percent of overall ERG abnormalities and percent of Class 2+Edel per specimen were calculated. ERG expression was evaluated using DAKO FLEX Monoclonal Rabbit Anti-Human ERG Clone EP111. For each slide, H scores (H score =intensity X percentage of positive cells) from both tumor areas and benign prostate epithelium areas were assigned. The IHC score was defined as “H score from tumor minus H score from benign prostate epithelium”. IHC score &gt; 0 was considered positive. Statistical analysis was conducted using JMP 10. Results: Of the 52 RP cases, 9 had the ERG 2+Edel rearrangement (cutoff &gt;2%), 25 had Edel or Esplit rearrangements (cutoff &gt;45%), and 27 had no ERG rearrangements by FISH. The overall Percent Agreement (OPA) between the ERG IHC and FISH (any class of ERG rearrangements) was 90% with 95% Confidence Interval (CI) (79%, 96%). However, for the ERG 2+Edel group, the OPA between the ERG IHC and FISH 2+Edel was 71%, and 62% of IHC positives were false positive. Thus IHC does not discriminate between the 2+Edel, Esplit or Edel forms of ERG while FISH identifies each class of rearrangement. Conclusions: IHC assay allows the detection of overall ERG abnormalities, however it does not discriminate ERG Class 2+Edel, which is consistently reported to be of prognostic significance. Further studies are required to confirm prognostic utility of ERG rearrangements and protein expression in CaP.
Congenital Heart Defects in the United States
Authors: Suzanne M. Gilboa, Owen J. Devine, James E. Kucik, Matthew E. Oster, Tiffany Riehle-Colarusso, Wendy N. Nembhard, Ping Xu, Adolfo Correa, Kathy Jenkins, Ariane J. Marelli
Journal: Circulation (2016)

Background: Because of advancements in care, there has been a decline in mortality from congenital heart defects (CHDs) over the past several decades. However, there are no current empirical data documenting the number of people living with CHDs in the United States. Our aim was to estimate the CHD prevalence across all age groups in the United States in the year 2010. Methods: The age-, sex-, and severity-specific observed prevalence of CHDs in Québec, Canada, in the year 2010 was assumed to equal the CHD prevalence in the non-Hispanic white population in the United States in 2010. A race-ethnicity adjustment factor, reflecting differential survival between racial-ethnic groups through 5 years of age for individuals with a CHD and that in the general US population, was applied to the estimated non-Hispanic white rates to derive CHD prevalence estimates among US non-Hispanic blacks and Hispanics. Confidence intervals for the estimated CHD prevalence rates and case counts were derived from a combination of Taylor series approximations and Monte Carlo simulation. Results: We estimated that ≈2.4 million people (1.4 million adults, 1 million children) were living with CHDs in the United States in 2010. Nearly 300 000 of these individuals had severe CHDs. Conclusions: Our estimates highlight the need for 2 important efforts: planning for health services delivery to meet the needs of the growing population of adults with CHD and the development of surveillance data across the life span to provide empirical estimates of the prevalence of CHD across all age groups in the United States.
Detection of Chronic Kidney Disease in Patients With or at Increased Risk of Cardiovascular Disease
Authors: Frank C. Brosius, Thomas H. Hostetter, Ellie Kelepouris, Mark M. Mitsnefes, Sharon M. Moe, Michael A. Moore, Subramaniam Pennathur, Grace L. Smith, Peter W.F. Wilson
Journal: Circulation (2006)

Chronic kidney disease (CKD) occurs commonly in patients with cardiovascular disease. In addition, CKD is a risk factor for the development and progression of cardiovascular disease. In this advisory, we present recommendations for the detection of CKD in patients with cardiovascular disease. CKD can be reliably detected with the combined use of the Modification of Diet in Renal Disease equation to estimate glomerular filtration rate and a sensitive test to detect microalbuminuria. All patients with cardiovascular disease should be screened for evidence of kidney disease with these two determinations.
PD1-3-8: Diagnostic yield of flexible bronchoscopy without fluoroscopic guidance in evaluating lung masses
Authors: Sang Haak Lee, Shin Ae Park, Sung Kyung Kim, Jin Woo Kim, Yong Hyun Kim, Seung Joon Kim, Hyoung Kyu Kim, Young Kyoon Kim, Kwan Hyoung Kim, Hwa Sik Moon
Journal: Journal of Thoracic Oncology (2007)
Evolution of the haemagglutinin gene of the influenza A(H1N1)2009 virus isolated in Hong Kong, 2009–2011
Authors: G C Mak, C K Leung, K C Cheng, K Y Wong, W Lim
Journal: Eurosurveillance (2011)

Phylogenetic analysis of the haemagglutinin (HA) gene shows that the influenza A(H1N1)2009 viruses collected in Hong Kong clustered in two main branches characterised by the E391E and E391K amino acids. The main branch E391K evolved in two sub-branches with N142D and S202T mutations that first appeared in March and July 2010, respectively, with the latter becoming the predominant strain. These genetic variants that emerged display similar antigenic characteristics.Concurrent with genetic surveillance, laboratories should continue monitoring the circulating viruses antigenically.