tbuckley/cabot-search huggingface dataset:
Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis
Authors: Sara McArdle, Zbigniew Mikulski, Klaus Ley
Journal: The Journal of Experimental Medicine (2016)

Intravital imaging is an invaluable tool for understanding the function of cells in healthy and diseased tissues. It provides a window into dynamic processes that cannot be studied by other techniques. This review will cover the benefits and limitations of various techniques for labeling and imaging myeloid cells, with a special focus on imaging cells in atherosclerotic arteries. Although intravital imaging is a powerful tool for understanding cell function, it alone does not provide a complete picture of the cell. Other techniques, such as flow cytometry and transcriptomics, must be combined with intravital imaging to fully understand a cell's phenotype, lineage, and function.
Studies of Various Tests for Malignant Neoplastic Diseases. I. The Reduction of Methylene Blue by Plasma&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: N ERIKSEN, L D ELLERBROOK, S W LIPPINCOTT
Journal: JNCI Journal of the National Cancer Institute (1951)
ECDC guidance on chlamydia control in Europe: next steps
Authors: M J van de Laar, J Fontaine
Journal: Eurosurveillance (2009)

On 30 June 2009, the European Centre for Disease Prevention and Control (ECDC) launched the guidance on chlamydia control in Europe. This guidance document aims to support the European Union Member States in developing and improving their national chlamydia control strategies.
PWE-154 The use of glasgow predictive scoring (gps) in determining patient survival following oesophageal and gastric resection for malignant disease
Authors: I Thomas, A Tamijmarane, R Coggins
Journal: Gut (2015)

<h3>Introduction</h3> Oesophageal and gastric cancer resections carry a high risk of morbidity and mortality.<sup>1</sup>It is important that patients undergoing such surgery survive long enough to reap the benefits of resection. Pre-operative CRP and Albumin levels are simple markers that can be combined to form a Glasgow prognostic score (GPS), which has demonstrable prognostic value in colorectal cancers.<sup>2,3 </sup>The aim of this is study is to assess whether GPS can predict patient survival following oesophageal and gastric resections for malignant disease. <h3>Method</h3> NHS Highland holds a prospective database of all patients undergoing oesophageal and gastric resections for malignant disease. This database was reviewed for patients operated on between January 2005–June 2014. Data on pre-operative CRP and Albumin levels were collected retrospectively from the trust–s SCISTORE<sup>®</sup>results system, to calculate a GPS score: <b>GPS-0: CRP &lt;10 mg/L</b> <b>GPS-1: CRP &gt; 10 mg/L, Albumin &gt; 35 g/L</b> <b>GPS-2: CRP &gt; 10 mg/L; Albumin &lt; 35 g/L</b> TNM staging of the pathology specimen was also recorded to derive a pathology score: <b>TxNyMx: Pathology score = x + y + z</b> Data on GPS, survival and pathology scores were analysed in SPSS<sup>®</sup>version 21 using one-way ANOVA tests. <h3>Results</h3> The database contained 179 patients. Of these 110 (61.5%) had both pre-operative CRP and Albumin levels documented to derive a GPS score. 61 patients had a GPS score of 0, 34 a score of 1 and 15 a score of 2. The median survival post-resection was 31, 24.5 and 6 months respectively. One-way ANOVA demonstrated a significant difference in survival between groups (p-value of 0.049). GPS scores were also compared to pathology scores. The mean pathology score was 2.88, 3.04 and 4.11 for the respective GPS groups of 0–2, with ANOVA tests again demonstrating a significant difference (p-value of 0.017). <h3>Conclusion</h3> GPS is a useful marker for patients about to embark of oesophageal and gastric resectional surgery for malignant disease. Patients with a GPS score of 2 appear to be poor surgical candidates, with more advanced tumours and survivals too short to derive benefit from surgical resection. The use of GPS scoring could be a helpful tool in MDT decision making. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> D. Amico T. Outcomes after surgery for oesophageal cancer. <i>Gastrointest. Cancer Res</i>. 2007 September-October;1(5):188-196 McMillan DC, Crozier JE, Canna K, <i>et al</i>. Evaluation of an inflammation-based prognostic score (GPS) in patients undergoing resection for colon and rectal cancer. Int J Colorectal Dis. 2007;22:881–6 Nakagawa K, Tanaka K, Kazunori N, <i>et al</i>. The modified glasgow prognostic score as a predictor of survival after hepatectomy for colorectal liver metastases. Ann Surg Oncol. 2014;21:1711–1718
Identification of Protein Coding Regions of Rice Genes Using Alternative Spectral Rotation Measure and Linear Discriminant Analysis
Authors: Jiao Jin
Journal: Genomics Proteomics & Bioinformatics (2004)

Abstract An improved method, called Alternative Spectral Rotation (ASR) measure, for predicting protein coding regions in rice DNA has been developed. The method is based on the Spectral Rotation (SR) measure proposed by Kotlar and Lavner, and its accuracy is higher than that of the SR measure and the Spectral Content (SC) measure proposed by Tiwari et al. In order to increase the identifying accuracy, we chose three different coding characters, namely the asymmetric, purine, and stop-codon variables as parameters, and an approving result was presented by the method of Linear Discriminant Analysis (LDA).
AB1073 Accuracy Assessment of Remission Criteria in Relation to Ultrasound Findings in Hands and Feet in Patients with Rheumatoid Arthritis
Authors: M.V. Martire, D. Puente Trigo, V.M. Duarte, L. Marino Claverie, G. Amaya Crespo, M. Manzano, L. Carlevaris, A. Secco, M. Mamani
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Currently, one of the main goals of rheumatoid arthritis treatment is to attain remission. Stricter criteria, namely CDAI, SDAI ACR/EULAR Boolean have been proposed. Moreover, DAS28 is criticized for the exclusion of foot joints assessment. However the degree of agreement that they have with the ultrasound findings in patienrs in remission is not well known. <h3>Objectives</h3> The aim of our study is to evaluate the degree of agreement between the state of remission as measured by different stricter criteria and the absence of activity assessed by ultrasound of hands and toes. <h3>Methods</h3> We included consecutive patients diagnosed with RA according to ACR EULAR 2010 criteria being in remission defined as DAS28 &lt;2.6. We evaluated whether stricter criteria were met (CDAI, SDAI, Boolean, Boolean without EVA). A rheumatologist specialized in musculoskeletal ultrasound, who was unaware of the state of activity, performed ultrasonography on hands and toes. Systematic evaluation was performed on grayscale and power Doppler technique with multifrequency linear transducer (10-18MHz) in longitudinal and transverse sections of the radiocarpal joint, second and third metacarpophalangeal, second and third proximal interphalangeal in both hands and second to fifth articulation metatarsophalangeal (all of them bilateral). Lack of activity was defined when the patient had no exudative synovitis grade II and III, and power Doppler grade II and III in any of the evaluated joints. <h3>Results</h3> 100 ultrasounds were performed in 100 patients, 80% were women (n=80) and the mean age was 52.7 DS 12. There were no differences in age, sex, duration of disease, treatment, or RF and antiCCO positivity between patients with and without ultrasound activity. Table 1 shows the state of remission of the evaluated patients. Table 2 shows the degree of agreement among different criteria, and the absence of activity assessed by ultrasound in hands and feet. <h3>Conclusions</h3> There was no agreement between the state of remission measured by the various strict criteria and the absence of activity assessed by ultrasound feet in this study population. Only acceptable agreement was found with the Boolean criterion that excludes EVA on hands was found. <h3>References</h3> Felson DT, Smolen JS, Wells G, Zhang B, van Tuyl LH, Funovits J, et al. American College of Rheumatology; European League Against Rheumatism. American College of Rheumatology/European League Against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials. Arthritis Rheum. 2011; 63:573-86. <h3>Disclosure of Interest</h3> None declared
Complication of an Endoscopic Tattoo
Authors: P Del Rio, P Dell'Abate
Journal: Endoscopy (2003)

Figure 1 Abdominal pain and fever persisted for 2 months in a 57-year-old woman, following an endoscopic tattooing procedure after polypectomy of a pedunculated polyp. Intra-abdominal and pelvic diffusion of ink could be seen.
Validation study of a prognostic classification system in patients with metastatic colorectal cancer who received irinotecan-based second-line chemotherapy.
Authors: Kentaro Yamazaki, Yoichi Naito, Satoshi Yuki, Yasuyuki Kawamoto, Hirofumi Yasui, Toshimi Takano, Yoshito Komatsu, Kei Muro, Kohei Shitara
Journal: Journal of Clinical Oncology (2012)

624 Background:Previously, five prognostic factors (ECOG PS 2, pathologically poorly differentiated adenocarcinoma, peritoneal metastasis, PFS of 1st-line therapy &lt;6 months, and LDH &gt;400 IU/L) were identified in 124 patients with metastatic colorectal cancer who received irinotecan-based second-line chemotherapy (Shitara K, et al. ASCO-GI 2009). Patients were categorized into three prognostic groups (low-risk = no factors, intermediate-risk = 1 factor, high-risk = 2 or more factors), with significant differences in median overall survival (23.5, 14.6, and 5.5 months, respectively). The purpose of this study was to validate this prognostic classification in an external validation cohort. Methods: We retrospectively analyzed 198 patients with metastatic colorectal cancer who received irinotecan-based second-line chemotherapy after first-line oxaliplatin-based chemotherapy in 3 institutions. This was our validation cohort. Results: The median overall survival of this validation cohort was not significantly different from that of the generating cohort (12.1 vs. 14.6 months; P=0.47). The distribution of the three prognostic groups in the validation cohort was as follows: low-risk (n=68; 35%), intermediate-risk (n=80; 41%), high-risk (n=45; 23%), with a higher proportion of intermediate-risk patients in comparison with the generating cohort. The median overall survival of each prognostic group in the validation cohort was 19.8, 11.0, and 7.9 months, respectively, with significant differences among groups (P&lt;0.01), as was shown for the generating cohort. A similar tendency was observed for progression-free survival. Conclusions: Our results validated the previously defined prognostic classifications in patients with metastatic colorectal cancer who received irinotecan-based second-line chemotherapy. This classification may be useful as a stratification factor in clinical trials or in considering treatment strategies for individual patients.
Computer-assisted telephone administration of a structured interview for obsessive-compulsive disorder
Authors: L Baer, M W Brown-Beasley, J Sorce, A I Henriques
Journal: American Journal of Psychiatry (1993)

A computer-assisted telephone system using digitized human speech was developed to administer two rating scales for obsessive-compulsive disorder. For 18 patients, scores derived with this system agreed well with scores from human administration of the scales by telephone and paper-and-pencil scales returned by mail. This approach provides reliable, low-cost, and instantaneous data acquisition.
Case 80-1963
Authors: Frank C. Wheelock, Benjamin Castleman
Journal: New England Journal of Medicine (1963)

Presentation of CaseA forty-nine-year-old man entered the hospital because of weakness and chronic diarrhea.Diarrhea and abdominal distention developed during infancy, and ever since that time he had customarily passed 6 to 12 bulky, foul-smelling stools daily. His appetite had been voracious, and he had been active and in good health, having played professional basketball for seven years. Twenty years before admission he was told that he had pernicious anemia and was given injections of liver extract. Five years later he entered another hospital because of nausea, vomiting and increased frequency of bowel movements. A diagnosis of sprue was . . .
Convalescence at Home Following Hospitalization Among Persons 55 years of Age and Older. United States—July 1966-June 1967.
Authors: G A Gleeson
Journal: Annals of Internal Medicine (1973)

The data in this report describe the hospital and convalescent experience of older patients discharged to the home folIowing hospitalization in short-stay hospitals and surviving to the time of interview. An estimated 6.2 million discharges, involving 1 night or more of inpatient stay in short-stay hospitals, occurred in the U.S. civilian, noninstitutional population aged 55 years and over during an average 12-month period ending during July 1966-J une 1967 (table A). Among each 1,000 persons 55 years of age and over in the civilian, noninstitutional population, there was an average of 178.3 discharges from short-stay hospitals during the average 12-month period. Of these, 96.8 percent returned home following their discharge from the hospital. With advancing age, the rate of short-stay hospital discharges per 1,000 population increased, but the percent of those discharged to the home decreased slightly.
Multidisciplinary treatment in patients with leptomeningeal metastasis from gastric cancer
Authors: Koichi Mitsuya, Nakamasa Hayashi, Satoshi Hamauchi, Takahiro Tsushima, Nozomu Machida, Kentaro Yamazaki, Hirofumi Yasui, Hideyuki Harada, Tetsuo Nishimura, Yoko Nakasu
Journal: Annals of Oncology (2015)
NeoFLOT II: Multicenter phase II study with short time neoadjuvant chemotherapy (stNACT) with 5-FU, FA, oxaliplatin, and docetaxel in rectable adenocarcinoma of the gastresophageal junction and gastric adenocarcinoma (T3, T4, and/or LN+) with high R0 resection rate over 91.5%.
Authors: Karsten Ridwelski, Tobias Heina, Joerg Fahlke, Hendrik Kroening, Walter Asperger, Christoph Kahl, Ulrich Halm, Patrick Stuebs, Carl Meissner, Ronny Otto, Kathrin Zierau, Matthias Krueger
Journal: Journal of Clinical Oncology (2015)

4061 Background: Perioperative chemotherapy is standard of care in locally advanced gastroesophageal cancer (GEC included adenocarcinoma of gastroesophageal junction -GEJ- and gastric adenocarcinoma) in europe. the NeoFLOT II study had examined a short time neoadjuvant chemotherapy (stNACT) with only 4 cycles FLOT. Patients(pts.)3,T4 and/or nodepositive adenocarcinoma (GEC)were eligible for this multicenter phase II study. Methods: For stNACT, 5-FU 2600mg/sqm/24h on day (D) 1, FA 200mg/sqm/30min on D 1, oxaliplatin 85mg/sqm/1h on D 1 and docetaxel 50mg/sqm/2h on D 1 were admistrated every 2 weeks for two cycles. Application of adjuvant chemotherapy was not part of the protocol. Primary endpoint was the R0-resection rate. Secondary endpoints were toxicity, remission rate and rate of surgical complications. Results: A total of 49 pts. with a median age of 64years were enrolled in 5 centers. 46 pts. completed stNACT, 1 patient had only 1 cycle and 2 pts.had 3 cycles. 47 patients underwent surgery. R0-resection rate was 91,5% (43/47). We saw no pathological complete response (pCR) and 19 partial responses (pPR 45,2%). 3/49 pts. developed progressive disease (6,1%). Grade 3-4 toxicities included neutropenia (42,9%), febrile neutropenia 8,2% and diarrhea 22,4%. 2 pats. died after resection (4,3%). Conclusions: StNACT with 4 cycles of FLOT is effective and tolerable in resectable GEC. R0-resection rate was very high. Clinical trial information: EudraCT-Nr. 2009-01260820 Neoflot.
PWE-113 The liver biopsy in alcoholic hepatitis: data from the steroids or pentoxifylline in alcoholic hepatitis (stopah) clinical trial
Authors: G Petts, K Lloyd, N Vergis, H Kudo, A Quaglia, E Forrest, M Thursz, R Goldin
Journal: Gut (2015)

<h3>Introduction</h3> The European Association for the Study of the Liver guidelines recommend the use of liver biopsy to confirm alcoholic steatohepatitis (ASH) in patients suspected to be suffering from alcoholic hepatitis and who are classified as high risk after prognostic assessment. Despite this it was only in 2014 that Altamirano <i>et al</i>published the first prognostic liver biopsy based scoring system for the evaluation of ASH (the Alcoholic Hepatitis Histological Score or AHHS). This work sought to validate their scoring system and further explore the utility of the liver biopsy in ASH. <h3>Method</h3> Two independent histopathologists, blinded to treatment and outcome, centrally reviewed liver biopsies of patients with clinically high-risk alcoholic hepatitis who had been recruited to the STOPAH trial. <h3>Results</h3> 93 (47%) of the 208 biopsies received were both adequate in quality and taken between admission and day 5 of trial treatment. 88% (82/93) had histological features diagnostic of ASH. 89% (32/36) of cases obtained as routine clinical practice were diagnostic of ASH compared to 79% (15/19) biopsied for diagnostic uncertainty. Clinically more severe liver disease was associated a higher rate of ASH diagnosis (82% of GAHS ≤8 vs. 97% of GAHS &gt;8). 65% (53/82) of biopsy proven cases of ASH were classified as severe by AHHS. This group had a significantly higher 28 day mortality rate than those classified as mild/moderate (18% vs. 0%, Fisher’s exact p = 0.02). AHHS severity positively correlated with baseline Maddrey’s Discriminant Function and Glasgow Alcoholic Hepatitis Score (r = 0.2, p = 0.045 and r = 0.3, p = 0.01 respectively). Clinical markers of severe disease positively correlated with biopsy features of severe disease including: - serum bilirubin with bilirubinostasis (r = 0.5, p= &lt;0.0001) - serum white cell and neutrophil count with lobular inflammation (r = 0.4, p = &lt;0.001) Elevation of serum alkaline phosphatase (ALP) and bilirubin are usually associated with more severe liver disease, however in this study they were seen to negatively correlate with certain biopsy features of more severe disease: - serum ALP negatively correlated with ductular changes (r = -0.2, p = 0.04) - serum bilirubin negatively correlated with Laennec fibrosis grading (r = -0.3, p = 0.01) <h3>Conclusion</h3> This work goes some way towards validating the AHHS classification. The work also highlights the parallels between clinical and histological parameters and documents negative correlations seen in other liver diseases but not previously noted in ASH. <h3>Disclosure of interest</h3> None Declared.
AB1246-HPR Immediate Effects of Thai Massage on Electromyogram and Pain Related Parameters in Patients with Upper Back Pain Associated with Myofascial Trigger points: A Randomized Controlled Study
Authors: V. Buttagat, T. Narktro, K. Onsrira, C. Pobsamai
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Myofascial pain syndrome (MPS) is a common chronic musculoskeletal syndrome characterized by chronic pain caused by one or several trigger points located in a taut band of skeletal muscle. Although the indigenous knowledge of Thai massage (TM) for relieving this syndrome has been practiced in Thailand for a long period of time, its effects on electromyogram (EMG) and pain in MPS has not yet been clearly verified. <h3>Objectives</h3> To determine the immediate effect of TM on muscle activity and pain related parameters in patients with upper back pain associated with myofascial trigger points. <h3>Methods</h3> Forty patients diagnosed with chronic upper back pain associated with myofascial trigger points were randomly allocated to receive a 30-minute session of either TM or sham microwave diathermy (sham MWD) using block randomized allocation. Pain intensity (Visual analog scale), Pressure pain threshold and EMG were measured before and immediately after the treatment sessions. The assessor who was blind to the group allocation conducted the measurements of all outcomes. <h3>Results</h3> Results indicated that the TM group showed a significant improvement in the pain intensity and pressure pain threshold after the treatment (p&lt;0.05). For these outcomes, similar changes were not observed in the sham MWD group (p&gt;0.05). Moreover, there were significantly higher in the improvement of pain intensity and pressure pain threshold in the TM group when compared with the sham MWD group (p&lt;0.05). Analysis of EMG in the TM group showed a significant decrease in muscle activity (p&lt;0.05) whereas no significant differences was found in the sham MWD group. This measure were also significantly different when compared between the groups (p&lt;0.05). <h3>Conclusions</h3> TM can decrease muscle activity and improve pain related parameters in this patient population. <h3>References</h3> Simons D.G., Travell J.G., Simons L.S. Myofascial pain and disfunction. The trigger point manual. Volumn 1, 2nd ed. Baltimore: Williams &amp; Wilkins; 1999. <h3>Acknowledgements</h3> The authors would like to express sincere thanks to all the patients who participated in the present study. This study was supported by Mae Fah Luang University and by Research Center in Back, Neck, Other Joint Pain and Human Performance (BNOJPH) Khon Kaen University. <h3>Disclosure of Interest</h3> None declared
The Development of Variations in Transplantability and Morphology Within a Clone of Mouse Fibroblasts Transformed to Sarcoma-Producing Cells &lt;italic&gt;In Vitro&lt;/italic&gt;
Authors: K K SANFORD, G D LIKELY, W R EARLE
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article The Development of Variations in Transplantability and Morphology Within a Clone of Mouse Fibroblasts Transformed to Sarcoma-Producing Cells In Vitro Get access Katherine K. Sanford, Katherine K. Sanford Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gwendolyn D. Likely, Gwendolyn D. Likely Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle Wilton R. Earle Tissue Culture Section, Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 215–237, https://doi.org/10.1093/jnci/15.2.215 Published: 01 October 1954 Article history Received: 24 March 1954 Published: 01 October 1954