tbuckley/cabot-search huggingface dataset:
Outbreak of psittacosis in a group of women exposed to Chlamydia psittaci-infected chickens
Authors: K Laroucau, R Aaziz, L Meurice, V Servas, I Chossat, H Royer, B de Barbeyrac, V Vaillant, J L Moyen, F Meziani, K Sachse, P Rolland
Journal: Eurosurveillance (2015)

Eight cases of psittacosis due to Chlamydia psittaci were identified in May 2013 among 15 individuals involved in chicken gutting activities on a mixed poultry farm in France. All cases were women between 42 and 67 years-old. Cases were diagnosed by serology and PCR of respiratory samples. Appropriate treatment was immediately administered to the eight hospitalised individuals after exposure to birds had been discovered. In the chicken flocks, mainly C. gallinacea was detected, a new member of the family Chlamydiaceae, whereas the ducks were found to harbour predominantly C. psittaci, the classical agent of psittacosis. In addition, C. psittaci was found in the same flock as the chickens that the patients had slaughtered. Both human and C. psittaci-positive avian samples carried the same ompA genotype E/B of C. psittaci, which is widespread among French duck flocks. Repeated grassland rotations between duck and chicken flocks on the farm may explain the presence of C. psittaci in the chickens. Inspection by the veterinary service led to temporary closure of the farm. All birds had to be euthanised on site as no slaughterhouses accepted processing them. Farm buildings and grasslands were cleaned and/or disinfected before the introduction of new poultry birds.
MLVA-NET – a standardised web database for bacterial genotyping and surveillance
Authors: G Guigon, J Cheval, R Cahuzac, S Brisse
Journal: Eurosurveillance (2008)

Strain typing is an important aid to surveillance networks and outbreak investigations of infectious diseases [1]. MLVA (Multilocus VNTR Analysis, with VNTR standing for Variable Number of Tandem Repeats) has emerged as a highly discriminatory and widely applicable genotyping method that is now being applied for strain tracking in a growing number of bacterial pathogens [2,3]. The genomic loci containing tandem repeats are often maintained among strains of a bacterial species, while individual strains harbour different copy numbers that can be determined simply by PCR amplification. Similar to sequence-based methods such as Multilocus Sequence Typing (MLST), the MLVA method indexes genetic variation at well defined genomic loci and produces reproducible allelic profiles that can be coded in a simple digital format. Hence, they represent an attractive alternative to banding profile-based methods such as pulsed-field gel electrophoresis (PFGE), which requires dedicated efforts (e.g. http://www.cdc.gov/pulsenet) in order to produce fingerprinting data that are comparable across laboratories. Indeed, to be useful to surveillance networks and for global epidemiology, a genotyping method has to be technically accessible, reproducible and to yield easily portable data. In addition, electronic databases that are made accessible through the Internet can render exchange and comparison of data among laboratories very effective for local, national, and international surveillance. Existing databases of MLST data accessible through web portals (http://www.pubmlst.org,http://www.mlst.net, http://www.pasteur.fr/mlst) represent a common language for strain typing that has proven extremely useful for collaborative research and global epidemiology of bacterial and fungal pathogens [4]. However, given the much faster evolutionary rate of tandem repeats compared to nucleotide sequences, MLVA markers provide much improved resolution compared to MLST, thus representing a subtyping tool that is especially useful for strain discrimination in genetically homogeneous pathogens, such as M. tuberculosis [5], Bacillus anthracis [6] or Salmonella enterica serotype Typhimurium [7]. Web-accessible MLVA databases are not yet widely used for international collaboration [8], but the development in this area is very active (http://mlva.u-psud.fr/, http://www.mlva.eu/, http://www.miru-vntrplus.org).
Significance of Repair of Human DNA: Evidence From Studies of Xeroderma Pigmentosum
Authors: J H Robbins
Journal: JNCI Journal of the National Cancer Institute (1978)

A) Binuclear Cells UV 81.0I b CRL1333 x XP9BE (Group C) Binuclear Cells UV c CRL 1333 x XP5BE (Group D) Binuclear Cells UV TEXT•FlGlIRE I.-Histograms of autoradiographs showing that strain CRL 1333 is in group C. Methods as in legends to figs. 2 and 3 and (1.49); explanation and discussion are in text.(Data are from Robbins ]H
Hypertrophic Riedel??s Lobe of the Liver
Authors: R SHAM, A SAIN, L SILVER
Journal: Clinical Nuclear Medicine (1978)

Riedel's lobe, noted on 99mTc-sulfur colloid liver scintigraphy, was present in 86 (3.3%) of 2604 patients reviewed. Hypertrophied Riedel's lobe was found in 30 cases of which 25 (83%) were females and 5 (17%) were males. Liver scintigraphy will detect the presence of a hypertrophied Riedel's lobe and is recommended in all cases of right sided abdominal masses.
Abstract P2-05-04: The development of the metastatic site pattern during time in different subtypes of breast cancer
Authors: H Lindman, A Haji
Journal: Cancer Research (2016)

Abstract Introduction: The most common metastatic sites in breast cancer (BC) are bone, lung and liver, but metastases to CNS, other visceral organs, skin and lymph nodes are often seen. Depending on the BC subtypes there are data on different patterns of the metastatic sites. However, little is known about the risk for development of new metastatic sites during the course of the disease. Possibly, the development of new sites of the disease is signs of novel intrinsic capabilities of the metastases that might be explained by new mutations. Primary aim of this study was to examine the metastatic pattern and development of new metastatic sites in different BC subgroups. Materials and Methods: This is a population based cohort study covering patients in the Uppsala County treated for metastatic BC (MBC) from 2009 to 2014. The information was collected from the real-time treatment registry and medical records. The distant sites were classified as bone, lung/pleura, soft tissue, other visceral and CNS and the timing was defined in steps starting with M1 when patient first was defined as having MBC. The BC subtypes were defined as luminal A, luminal B, HER2-positive (HER2) and triple negative (TN) based on immunohistochemical analyses. The metastatic patterns at death were compared with the patterns at M1. Results: Totally 391 patients with MBC with a median age of 65 years were included. Median disease-free survival was 51 months. The development of metastases in new sites occurred in up to three distinguished steps, with median lag times of 22, 13 and 14 months, respectively. The median survival from M1 was 69, 37, 64 and 17 months for the luminal A, luminal B, HER2 and TN subtypes. The frequencies of metastases in in first (M1) and subsequent sites (next) in each subtypeM1%/next%BoneLung/pleuraSoft tissueLiverOther visceralCNSLuminal A74/431/2122/1020/2816/151/4Luminal B66/1144/1438/327/3216/54/10HER246/1536/2042/1719/2810/1319/31TN27/746/1751/629/017/1117/17The sums of the figures represent the risk for metastases in a certain site at death. Conclusion: The pattern of metastatic sites at M1 in different BC subtypes does not represent the pattern for development of new metastatic sites during the course of the disease. We observed a significantly different risk for developing new metastatic sites depending on subtypes, most obvious regarding liver metastases. TNBC seemed to have less ability to develop new metastatic sites. Citation Format: Lindman H, Haji A. The development of the metastatic site pattern during time in different subtypes of breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-05-04.
Unintended Consequences of Changing the Definition of Posttraumatic Stress Disorder in<i>DSM</i>-<i>5</i>
Authors: Charles W. Hoge, Rachel Yehuda, Carl A. Castro, Alexander C. McFarlane, Eric Vermetten, Rakesh Jetly, Karestan C. Koenen, Neil Greenberg, Arieh Y. Shalev, Sheila A. M. Rauch, Charles R. Marmar, Barbara O. Rothbaum
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Prevalence and characteristics of mania in Chinese inpatients: a prospective study
Authors: Y Shan-Ming, C Deyi, C Y Zhen, J Jingsu, M A Taylor
Journal: American Journal of Psychiatry (1982)

Of 1,730 consecutive admissions to an acute inpatient psychiatric unit in China, 155 (8.9%) satisfied two sets of research diagnostic criteria for mania, a figure significantly greater than those previously reported in China. The authors studied 108 of these patients and found that their clinical characteristics were similar to those of Western patients; their response to treatment was excellent and their course benign. Their first-degree relatives had a high morbidity risk for affective disorder and a low morbidity risk for schizophrenia. The authors discuss the implications of their findings in China, where the use of lithium is uncommon because of the impression that mania is rare in China.
Durable remissions in stage III follicular lymphoma: interpret with caution.
Authors: S J Horning
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.6.838 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3295128 Durable remissions in stage III follicular lymphoma: interpret with caution. S J HorningxS J HorningSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.6.838 PDF "Durable remissions in stage III follicular lymphoma: interpret with caution.." Journal of Clinical Oncology, 5(6), pp. 838–839© 1987 by American Society of Clinical Oncology
Nosocomial infections and community clusters of pertussis in France, 2000-2005
Authors: I Bonmarin, I Poujol, D Lévy-Bruhl
Journal: Eurosurveillance (2007)

Pertussis is not a notifiable disease in France. In addition to a paediatric hospital sentinel surveillance system, pertussis epidemiological data have, since 1996, been gathered through the voluntary notification of community clusters by general practitioners, and since 2001 by the statutory notification of nosocomial infection to the relevant local health authority. The local health authority forwards the information to the French National Institute for Surveillance (InVS). The objective of this study was to analyse pertussis data outside the routine paediatric hospital sentinel surveillance system. We gathered all the information concerning healthcare-associated infections and community clusters of pertussis (specific forms, investigation reports, emails etc.) reported to the InVS between 2000 and 2005. The InVS received and analysed 67 reports with a total of 595 cases. Almost half of the reports (n=31) came from hospitals, and healthcare workers were usually first affected. Control measures were put in place in 22 healthcare facilities and the average duration of an outbreak episode was 48 days. Outside healthcare facilities, clusters were reported also from 17 daycare facilities or schools and five workplaces. Among the 595 cases, six deaths occurred in children under seven months of age. Pertussis is still occurring in France and affects those who are not or who are no longer protected by the vaccine. Infection of infants within the household could be prevented if their parents and siblings were immunised. The number and size of pertussis clusters in hospitals could be reduced through immunisation of health staff, and timely and adequate outbreak management.
Abstract 13021: Regional Electromechanical Heterogeneity in the Rabbit Wild-Type and Long-QT-Syndrome Heart
Authors: Franz F Dressler, Ilona Bodi, Marius Menza, Stephanie Perez-Feliz, Manfred Zehender, Christoph Bode, Jan C Behrends, Gunnar Seemann, Katja E Odening
Journal: Circulation (2015)

Introduction: Long-QT-syndrome type 2 (LQT2) has been linked to heterogeneities on a whole-heart scale. Here, we systematically investigated regional electromechanical function in wild-type (WT) and transgenic LQT2 rabbits. Methods: Rabbits (n=7 WT, 6 LQT2) were examined by phase-contrast magnetic resonance imaging (MRI) to assess cardiac wall movement velocities. A novel data-processing algorithm was developed to calculate regional contraction-like profiles. Using patch clamping, action potentials (AP) were recorded from cardiomyocytes isolated from the left ventricular (LV) apex and LV, septum, and right ventricular base. Cav1.2, KCNQ1, Kv1.4, Kir2.1, Nav1.5, SERCA, RyR2, Phospholamban (PLB) and NCX expression were quantified by western blot. Results: AP was longer in WT LV apex than in all three base regions (APD90 median 291 vs. 202, 209, 196ms; p&lt;0.01, 0.05, 0.05). MRI revealed an earlier, longer and stronger contraction in LV apex than LV base (fig. 1) in both genotypes and an additional relaxation impairment in LQT2 LV apex (fig. 1B). In WT, 5 proteins were downregulated in LV apex vs. LV base (KCNQ1, p=0.07; Cav1.2, p&lt;0.01; Kv1.4, NCX, PLB, p&lt;0.05). In LQT2 no similar profile was present. Instead, NCX and PLB were upregulated apically compared to WT (p&lt;0.05). An in silico model integrating the quantitative WT differences reproduced a contraction and AP prolongation in apex vs. base. Conclusions: Electromechanical heterogeneity is not exclusive to the arrhythmogenic heart: we demonstrate the presence of an electromechanical, in silico reproducible apico-basal gradient in healthy rabbit hearts with an associated regionally heterogeneous expression of 5 key proteins. This pattern can be explained logically as apical mechanical dominance reduces outflow resistance and increases efficiency. LQT2 rabbits show increased intra-cardiac heterogeneity with diastolic asynchrony that can be determined non-invasively and might have prognostic value.
The Phenotype and Genotype of Mevalonate Kinase Deficiency: A Series of 114 Cases From the Eurofever Registry
Authors: Nienke M. ter Haar, Jerold Jeyaratnam, Helen J. Lachmann, Anna Simon, Paul A. Brogan, Matteo Doglio, Marco Cattalini, Jordi Anton, Consuelo Modesto, Pierre Quartier, Esther Hoppenreijs, Silvana Martino, Antonella Insalaco, Luca Cantarini, Loredana Lepore, Maria Alessio, Inmaculada Calvo Penades, Christina Boros, Rita Consolini, Donato Rigante, Ricardo Russo, Jana Pachlopnik Schmid, Thirusha Lane, Alberto Martini, Nicolino Ruperto, Joost Frenkel, Marco Gattorno
Journal: Arthritis & Rheumatology (2016)

Objective Mevalonate kinase deficiency (MKD) is a rare metabolic disease characterized by recurrent inflammatory episodes. This study was undertaken to describe the genotype, phenotype, and response to treatment in an international cohort of MKD patients. Methods All MKD cases were extracted from the Eurofever registry (Executive Agency for Health and Consumers project no. 2007332), an international, multicenter registry that retrospectively collects data on children and adults with autoinflammatory diseases. Results The study included 114 MKD patients. The median age at onset was 0.5 years. Patients had on average 12 episodes per year. Most patients had gastrointestinal symptoms (n = 112), mucocutaneous involvement (n = 99), lymphadenopathy (n = 102), or musculoskeletal symptoms (n = 89). Neurologic symptoms included headache (n = 43), cerebellar syndrome (n = 2), and mental retardation (n = 4). AA amyloidosis was noted in 5 patients, almost twice as many as expected from findings in previous cohorts. Macrophage activation syndrome occurred in 1 patient. Patients were generally well between attacks, but 10–20% of the patients had constitutional symptoms, such as fatigue, between fever episodes. Patients with p.V377I/p.I268T compound heterozygosity had AA amyloidosis significantly more often. Patients without a p.V377I mutation more often had severe musculoskeletal involvement. Treatment with nonsteroidal antiinflammatory drugs relieved symptoms. Steroids given during attacks, anakinra, and etanercept appeared to improve symptoms and could induce complete remission in patients with MKD. Conclusion We describe the clinical and genetic characteristics of 114 MKD patients, which is the largest cohort studied so far. The clinical manifestations confirm earlier reports. However, the prevalence of AA amyloidosis is far higher than expected.
Utility of measuring FEV<sub>0.75</sub>/FVC ratio in preschoolers with uncontrolled wheezing disorder
Authors: Véronique Nève, Sébastien Hulo, Jean-Louis Edmé, Sophie Boileau, Georges Baquet, Guillaume Pouessel, Caroline Thumerelle, Antoine Deschildre, Régis Matran
Journal: European Respiratory Journal (2016)

Uncontrolled wheezing disorder is common in preschoolers and disease control assessment is challenging as parents frequently overestimate the extent to which their child's disease is controlled. This is the first study of forced expiratory volume in t s (FEV t )/forced vital capacity (FVC) ratio measurements ( i.e. FEV 1 /FVC, FEV 0.75 /FVC and FEV 0.5 /FVC) in wheezy preschoolers in relation to disease control. Our objective was to evaluate whether FEV t /FVC ratios less than the lower limit of normal (LLN; z-score &lt;−1.64) were associated with uncontrolled wheezing disorder in preschoolers. Valid FVC, FEV 1 , FEV 0.75 and FEV 0.5 values were obtained in 92 healthy and 125 wheezy (62% uncontrolled) children (3–5 years). Associations between spirometry value &lt;LLN, disease classification (healthy/wheezy) and disease control classifications (controlled/uncontrolled disease) were estimated using logistic regression. FEV 0.75 /FVC or FEV 0.5 /FVC ratios &lt;LLN were associated with wheezing disorder (OR 9.78, 95% CI 3.70–25.88 and OR 6.64, 95% CI 2.24–19.66; all p&lt;0.001). Only an FEV 0.75 /FVC ratio &lt;LLN was associated with uncontrolled wheezing disorder (OR 2.53, 95% CI 1.12–5.68; p=0.025). FEV 0.75 /FVC ratio is a useful surrogate outcome index to evaluate the control of the wheezing disease of preschoolers.
The interface between sexual dysfunctional and marital conflict
Authors: L M Hartman
Journal: American Journal of Psychiatry (1980)

The author used a self-rating scale to assess marital happiness and sexual functioning in a sample of 20 couples referred to an outpatient family therapy unit. Evaluation of couples in structured interactions indicated important differences in the quality and intensity of relationship difficulties observed. Analysis of variance clearly showed that sexual dysfunction and marital distress may operate independently of one another. Thus effective treatment of marital discord may be neither a necessary nor sufficient condition for improvement in sexual functioning.
Abstract 36: Functional characterization of ERBB2 mutations and response to targeted therapies
Authors: Hannah Johnsen, Aphrothiti Hanrahan, Alexis Jones, David Solit
Journal: Clinical Cancer Research (2016)

Abstract Amplification of HER2 (ERBB2) has been well characterized as an oncogenic driver, but only recently have mutations in ERBB2 also been shown to have activating and tumorigenic potential. We sought to characterize a large number of ERBB2 mutations seen in sequencing data from patients at MSKCC as well as the cBioPortal for Cancer Genomics, and determine the therapeutic response of these mutations to HER2 targeted therapies. HER2 is a transmembrane tyrosine kinase that is responsible for regulating cell growth and proliferation, among other cell processes. The ERBB2 gene is amplified in approximately 25% of breast cancers and in this disease, HER2 directed therapies are now a component of standard care. More recently, ERBB2 mutations were identified in a variety of cancers, most commonly cancers of the urinary tract but also at lower frequency in cancers of the breast, stomach, colon and lung, among others. Recent data has shown that select ERBB2 mutations activate HER kinase signaling and promote anchorage independent growth in vitro and tumor formation in mice. However, only a small number of ERBB2 mutations have been reported and biologically characterized as oncogenic in preclinical models. Moreover, the therapeutic impact of ERBB2 mutations has not been validated. To screen for activating potential of a large number of ERBB2 mutations, cells were transiently transfected to express ERBB2 mutants generated using site-directed mutagenesis. Expression of several mutations led to increased receptor activation and downstream signaling, as determined by levels of phosphorylated HER2, AKT, ERK, and S6 protein, whereas other mutations had little impact on activity compared to a wild type HER2 control. Stable cell lines were then generated to express the activating mutations and tested for transforming ability in soft agar. Mutations promoted colony formation, with certain mutations producing more colonies. Cells were also grown in the presence of the dual EGFR/HER2 inhibitor, neratinib. While certain mutations were more sensitive to lower doses of neratinib, addition of neratinib at higher doses abrogated colony formation in soft agar for all mutations. While a number of ERRB2 mutations have been shown to have tumorigenic potential, not all mutations respond similarly to HER2 targeted therapies. We hope to create an annotated database of alterations so that in the future, patients can be screened for specific mutations to minimize ineffective and unnecessary treatment options. Citation Format: Hannah Johnsen, Aphrothiti Hanrahan, Alexis Jones, David Solit. Functional characterization of ERBB2 mutations and response to targeted therapies. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr 36.