tbuckley/cabot-search huggingface dataset:
Insomnia
Authors: S. Parmet, C. Lynm, R. M. Glass
Journal: JAMA (2003)

InsomniaI nsomnia (trouble falling asleep or staying asleep) is a common problem.It can cause daytime tiredness and sleepiness and difficulty paying attention at school or being alert at work.Insomnia can begin at an early age and affects people of all ages.Insomnia can be transient (short-term) and related to a specific condition like stress or travel, or it can be a chronic (long-term) problem that persists for many months and may be caused by another medical problem.The May 21, 2003, issue of JAMA includes an article about insomnia, its causes, and its treatments.
AB0085 The Effect of Immobility and Microgravity on Cartilage Metabolism
Authors: A.-M. Liphardt, G.-P. Brüggemann, N. Hamann, F. Zaucke, F. Eckstein, W. Bloch, A. Mündermann, S. Koo, J. Mester, A. Niehoff
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Moderate joint loading is essential to maintain cartilage health and function but the impact of immobilization on articular cartilage in healthy individuals is not well understood. One established biomarker for monitoring cartilage metabolism in relation to joint degeneration is cartilage oligomeric matrix protein (COMP)<sup>1</sup> which is sensitive to physiological loading<sup>2-4</sup> and 14-days of immobilization<sup>5</sup>. <h3>Objectives</h3> To analyze the effect of 21-days of head down tilt bed rest (HDT-BR) (Study1) and 5.5 months of microgravity (Study 2) on serum COMP concentration. <h3>Methods</h3> Study 1: Twelve healthy male subjects (34±8 yrs) participated in a 21-days HDT-BR study performed in a cross-over design. HDT-BR-only was the control (CON) condition. The intervention was resistive vibration exercise (RVE) alone or in combination with a nutrition intervention (NEX). 11 blood samples were collected before, during and after HDT-BR. Study 2: preliminary results of two astronauts will be presented. Blood samples were collected before and after 5.5 months on the International Space Station. Blood samples for both studies were taken in the morning after overnight-fast and 30 minutes supine rest. Biomarker concentrations were analyzed using commercial enzyme-linked immunosorbent assay (ELISA). Statistical analysis (IBM SPSS Statistics, 19.01) was performed using repeated measures ANOVA (p&lt;0.05). <h3>Results</h3> Study 1: Serum COMP concentration decreased with the first day of HDT (-24.7±12.5%; p&lt;0.05). Concentrations returned to baseline levels after subjects were mobile again. RVE and NEX interventions did not affect this result (NEX: - 14.3±16.7%; RVE: -15.7±9.2%). Study 2: Preliminary results (n=2) indicate a high increase (+39.9%; + 13.3%) in serum COMP concentration 7 days after return to gravity. Levels remain elevated until 30 days after landing. <h3>Conclusions</h3> These results suggest that cartilage ECM is sensitive to unloading and immobilization may initiate catabolic processes in cartilage metabolism. Investigating cartilage health in response to a stay in microgravity is a unique model and will broaden the understanding of cartilage metabolism. Future research should investigate sufficient exercise countermeasures in order to minimize negative effects of immobilization on cartilage health. <h3>References</h3> Saxne et al. Br J Rheumatol 1992; 31(9):583-91. Neidhart et al. Osteoarthritis Cartilage 2000, 8(3):222–9. Mündermann et al. Osteoarthritis Cartilage 2005, 13(1), 34–8. Niehoff et al. Osteoarthritis Cartilage 2009, 19(8):1003-10. Liphardt et al. Osteoarthritis Cartilage 2009, 17(12):1598–603. <h3>Disclosure of Interest</h3> None declared
Ischemic Heart Disease Mortality and Long-Term Exposure to Source-Related Components of U.S. Fine Particle Air Pollution
Authors: George D. Thurston, Richard T. Burnett, Michelle C. Turner, Yuanli Shi, Daniel Krewski, Ramona Lall, Kazuhiko Ito, Michael Jerrett, Susan M. Gapstur, W. Ryan Diver, C. Arden Pope
Journal: Environmental Health Perspectives (2015)

Fine particulate matter (PM2.5) air pollution exposure has been identified as a global health threat. However, the types and sources of particles most responsible are not yet known.We sought to identify the causal characteristics and sources of air pollution underlying past associations between long-term PM2.5 exposure and ischemic heart disease (IHD) mortality, as established in the American Cancer Society's Cancer Prevention Study-II cohort.Individual risk factor data were evaluated for 445,860 adults in 100 U.S. metropolitan areas followed from 1982 through 2004 for vital status and cause of death. Using Cox proportional hazard models, we estimated IHD mortality hazard ratios (HRs) for PM2.5, trace constituents, and pollution source-associated PM2.5, as derived from air monitoring at central stations throughout the nation during 2000-2005.Associations with IHD mortality varied by PM2.5 mass constituent and source. A coal combustion PM2.5 IHD HR = 1.05 (95% CI: 1.02, 1.08) per microgram/cubic meter, versus an IHD HR = 1.01 (95% CI: 1.00, 1.02) per microgram/cubic meter PM2.5 mass, indicated a risk roughly five times higher for coal combustion PM2.5 than for PM2.5 mass in general, on a per microgram/cubic meter PM2.5 basis. Diesel traffic-related elemental carbon (EC) soot was also associated with IHD mortality (HR = 1.03; 95% CI: 1.00, 1.06 per 0.26-μg/m3 EC increase). However, PM2.5 from both wind-blown soil and biomass combustion was not associated with IHD mortality.Long-term PM2.5 exposures from fossil fuel combustion, especially coal burning but also from diesel traffic, were associated with increases in IHD mortality in this nationwide population. Results suggest that PM2.5-mortality associations can vary greatly by source, and that the largest IHD health benefits per microgram/cubic meter from PM2.5 air pollution control may be achieved via reductions of fossil fuel combustion exposures, especially from coal-burning sources.Thurston GD, Burnett RT, Turner MC, Shi Y, Krewski D, Lall R, Ito K, Jerrett M, Gapstur SM, Diver WR, Pope CA III. 2016. Ischemic heart disease mortality and long-term exposure to source-related components of U.S. fine particle air pollution. Environ Health Perspect 124:785-794; http://dx.doi.org/10.1289/ehp.1509777.
Hydrostatic Balloon Catheters
Authors: J.H. Siegel, R.P. Yatto
Journal: Endoscopy (1984)

Disorders secondary to strictures of various segments of the gastrointestinal tract, e.g. esophagus, stomach, bile ducts, pancreas and colon often produce symptoms requiring continuing medical management or aggressive intervention. Until now, surgery has been required for failures of medical treatment. Endoscopically placed balloon catheters offer an alternative method for effectively treating a variety of gastrointestinal strictures. In this report we present examples of applications of balloon catheters in clinical gastroenterology.
Anzup 1302: a Randomised Phase 3 Trial of Accelerated Versus Standard Bep Chemotherapy for Patients with Intermediate and Poor-Risk Metastatic Germ Cell Tumours (P3Bep)
Authors: A. Long, G. Toner, M.R. Stockler, D.B. Thomson, V. Gebski, S. Yip, M. King, M. Friedlander, D.I. Quinn, N. Singhal, F. Roncolato, P. Grimison
Journal: Annals of Oncology (2014)
Final results of a single institution experience with a pediatric‐based regimen, the augmented Berlin–Frankfurt–Münster, in adolescents and young adults with acute lymphoblastic leukemia, and comparison to the hyper‐CVAD regimen
Authors: Michael E. Rytting, Elias J. Jabbour, Jeffrey L. Jorgensen, Farhad Ravandi, Anna R. Franklin, Tapan M. Kadia, Naveen Pemmaraju, Naval G. Daver, Alessandra Ferrajoli, Guillermo Garcia‐Manero, Marina Y. Konopleva, Gautam Borthakur, Rebecca Garris, Sa Wang, Sherry Pierce, Kurt Schroeder, Steven M. Kornblau, Deborah A. Thomas, Jorge E. Cortes, Susan M. O'Brien, Hagop M. Kantarjian
Journal: American Journal of Hematology (2016)

Several studies reported improved outcomes of adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) treated with pediatric‐based ALL regimens. This prompted the prospective investigation of a pediatric Augmented Berlin–Frankfurt–Münster (ABFM) regimen, and its comparison with hyper‐fractionated cyclophosphamide, vincristine, Adriamycin, and dexamethasone (hyper‐CVAD) in AYA patients. One hundred and six AYA patients (median age 22 years) with Philadelphia chromosome‐ (Ph) negative ALL received ABFM from October 2006 through March 2014. Their outcome was compared to 102 AYA patients (median age 27 years), treated with hyper‐CVAD at our institution. The complete remission (CR) rate was 93% with ABFM and 98% with hyper‐CVAD. The 5‐year complete remission duration (CRD) were 53 and 55%, respectively ( P = 0.98). The 5‐year overall survival (OS) rates were 60 and 60%, respectively. The MRD status on Day 29 and Day 84 of therapy was predictive of long‐term outcomes on both ABFM and hyper‐CVAD. Severe regimen toxicities with ABFM included hepatotoxicity in 41%, pancreatitis in 11%, osteonecrosis in 9%, and thrombosis in 19%. Myelosuppression‐associated complications were most significant with hyper‐CVAD. In summary, ABFM and hyper‐CVAD resulted in similar efficacy outcomes, but were associated with different toxicity profiles, asparaginase‐related with ABFM and myelosuppression‐related with hyper‐CVAD. Am. J. Hematol. 91:819–823, 2016. © 2016 Wiley Periodicals, Inc.
Targeted Disruption of USP14 and UCHL5 with the Novel Deubiquitinase Enzyme (DUB) Inhibitor, VLX1570, Induces Immense Proteotoxicity and Cell Death in Malignant Plasma Cells
Authors: Aneel Paulus, Sharoon Akhtar, Maja Kuranz-Blake, Anne J. Novak, Stephen Ansell, Morie A Gertz, Robert A Kyle, Peter Martin, Morton Coleman, Sikander Ailawadhi, Stig Linder, Asher Chanan-Khan, Kasyapa S. Chitta
Journal: Blood (2014)
Abstract 2006: Contrast-Enhanced MRI in the Hyperacute Phase of ST-Elevation Myocardial Infarction Predicts Late Myocardial Recovery
Authors: Eric Larose, Josep Rodes, Can Nguyen, Guy Proulx, Onil Gleeton, Jean-Pierre Dery, Bernard Noel, Gérald Barbeau, Louis Roy, Marc Amyot, Robert Delarochellière, Olivier Bertrand
Journal: Circulation (2008)

Left ventricular ejection fraction (EF) late after myocardial infarction determines whether patients will benefit from cardioverter/defibrillator (CV/D) implantation. At present, patients with acute ST elevation myocardial infarction (STEMI) are evaluated several months later to determine EF and CV/D indication following initial recovery. We determined whether contrast-enhanced MRI (CE-MRI) in the hyperacute phase of STEMI could predict late myocardial recovery. 50 patients with STEMI underwent CE-CMR within 12 hours of primary angioplasty (median 4h). All had follow-up CE-CMR &gt;6 months later. Global and segmental left ventricular function, morphology, perfusion and necrosis were determined and assessed by validated techniques (QMass, Medis, the Netherlands). In the hyperacute phase of STEMI, a greater cardiac output (4.2 vs 3.4 L/min, p=0.01) was measured due to significantly greater heart rate (72 vs 57 bpm, p&lt;0.01) despite similar stroke volumes (59 vs 60mL, p=NS) compared to &gt;6 months later. On average, LVEF did not significantly change from hyperacute STEMI to recovered phase (51 vs 54%, p=NS) but systolic wall thickening increased on average from 41 to 50% (p=0.01) due to compensatory increased systolic thickening of non-infarct related segments. LV mass decreased from 120 to 105 g (p=0.01) due to a decrease in mean wall thickness driven by infarct segment wall thinning (9.2 vs 8.4mm, p&lt;0.01). Microvascular function improved significantly (time to 50% enhancement on first-pass CE-MRI: 24.3 vs 21.7ms, p=0.03). Contrary to prior reports of “scar shrinkage” comparing necrosis in the first week after STEMI and 6 months later, necrosis relative to total myocardial volume did not differ between the hyperacute phase and &gt;6 months (20 vs 18%, p=0.46). Furthermore, the transmural extent of necrosis, a potent predictor of functional recovery, did not significantly change from the hyperacute to the recovered phase of STEMI (mean 17 vs 14%, p=0.38). CE-MRI in the hyperacute phase of STEMI is a powerful predictor of long-term myocardial function and necrosis which could prove useful for very early risk stratification and future targeting of appropriate therapies.
Phase II Trial Of Initial Safety and Toxicity Prior To The Phase III Trial Of Lenalidomide Versus Observation Alone In Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma (E3A06): A Trial Coordinated By The Eastern Cooperative Oncology Group
Authors: Sagar Lonial, Susanna Jacobus, Matthias Weiss, Rafael Fonseca, Madhav V. Dhodapkar, S. Vincent Rajkumar
Journal: Blood (2013)
Ki-1-positive anaplastic large-cell lymphoma: a clinicopathologic entity?
Authors: M E Kadin
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.4.533 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 1648595 Ki-1-positive anaplastic large-cell lymphoma: a clinicopathologic entity? M E KadinxM E KadinSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.4.533 First Page PDF © 1991 by American Society of Clinical Oncology
Relationship Between Hydration and Proton Nuclear Magnetic Resonance Relaxation Times in Tissues of Tumor-Bearing and Non-Tumor-Bearing Mice: Implications for Cancer Detection 2
Authors: Carlton F. Hazlewood, Gregor Cleveland, Daniel Medina
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Relationship Between Hydration and Proton Nuclear Magnetic Resonance Relaxation Times in Tissues of Tumor-Bearing and Non-Tumor-Bearing Mice: Implications for Cancer Detection Get access Carlton F. Hazlewood, Carlton F. Hazlewood Search for other works by this author on: Oxford Academic PubMed Google Scholar Gregor Cleveland, Gregor Cleveland Search for other works by this author on: Oxford Academic PubMed Google Scholar Daniel Medina Daniel Medina Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 6, June 1974, Pages 1849–1853, https://doi.org/10.1093/jnci/52.6.1849 Published: 01 June 1974 Article history Received: 03 January 1974 Accepted: 06 March 1974 Published: 01 June 1974
Mass Psychogenic Illness Attributed to Toxic Exposure at a High School
Authors: M D Goode
Journal: New England Journal of Medicine (2000)

Related Article by Edlow, J. A. Related Article by Jones, T. F. PubMed Citation To the Editor: Jones et al. (Jan. 13 issue)1 describe a Tennessee high school whose students and teachers fell victim to a mass psychogenic illness. One should not assume that mass psychogenic illness was the cause, however, given the finding that floor-drain traps in the index teacher's classroom (designed to keep gas out of the room) were noted to be dry and therefore not working.
Metastatic Colorectal Cancer: Lessons Learned, Future Possibilities
Authors: Alan P. Venook
Journal: Journal of the National Comprehensive Cancer Network (2016)

Survival of patients with metastatic colorectal cancer has dramatically improved over the past 20 years, primarily because physicians have become adept at using the many regimens approved for this patient population. Future advances may come from understanding molecular subtypes, finding and treating new actionable mutations, and harnessing the immune system.
Imipramine and alprazolam treatment of lactate-induced acute endogenous distress in nonhuman primates
Authors: G Sunderland, S Friedman, L A Rosenblum
Journal: American Journal of Psychiatry (1989)

The authors studied the response of 10 macaque monkeys to administration of sodium lactate, a panicogenic agent used in human panic disorder research, after treatment with the tricyclic antidepressant imipramine, the triazolobenzodiazepine alprazolam, or placebo. Both drugs effectively blocked the lactate-induced acute endogenous distress responses that had been reliably observed in the monkeys before drug treatment. Only alprazolam significantly reduced the occurrence of conditioned situational anxiety responses observed in the home cage. The alprazolam monkeys appeared to be sedated compared to the imipramine and placebo groups, and tremor and temporary exacerbation of anxious behaviors were observed during alprazolam withdrawal.
MEDICAL LITERATURE FOR VIENNA
Authors: C. Allbutt, J. Mackenzie
Journal: BMJ (1920)

SIR,&mdash;We have received from Professor Wenckebach sad news concerning the state of Vienna and Austria.Professor Wenckebach, although he accepted the call to Vienna but a short time before the war, has felt it his duty to abide with the suffering people who honoured him in the days of their prosperity.On the general misery of Austria in material needs it is not our purpose to dwell-it is but too well known ; the Pro- fessor's appeal is for the intellectual needs of a people whose souls are starving.In their penury he says that not a farthing can be had for books or journals, home or foreign, so that for the last three or four years neither teachers nor students have been ableto learn what is going on in academical circles.His direct appeal to Great Britain is for recent medical and scientific literature, for which students in all faculties are athirst.He describes the zest with which a group of students will pounce upon any fragment of a journal which may drift into their bare libraries.May we, then, beg your readers not to throw away journals, books, or papers, and perhaps, furthermore.to make some little sacrifice to spare such literature for the Vienna Medical School P Professor Starling was to have joined us in this appeal, but left for Bombay before his signature
THE IMPACT OF BIFURCATION LESIONS ON 6-MONTH ANGIOGRAPHIC AND LONG TERM CLINICAL OUTCOMES IN ACUTE MYOCARDIAL INFARCTION UNDERGOING PERCUTANEOUS CORONARY INTERVENTION WITH DRUG-ELUTING STENTS
Authors: Ji Young Park, Seung&ndash;Woon Rha, Amro Elnagar, Byoung Geol Choi, Sung II Im, Sunwon Kim, Jin Oh Na, Seongwoo Han, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Hong-Seog Seo, Chang Gyu Park, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2012)
Internal Mammary Node Irradiation: Does One Treatment Fit All?
Authors: Eli Avisar
Journal: Journal of Clinical Oncology (2016)

Clinical Onocology. 1 In this study, a cohort of patients with rightsided axillary node-positive breast cancer who received IMNI was compared with a similar cohort of patients with left-sided breast cancer who did not receive IMNI. The results revealed a statistically significant improved overall survival rate (hazard ratio, 0.86) and a lower rate of breast cancer–related mortality in patients with right-sided breast cancer who received IMNI. The reason for avoiding IMNI in the patients with left-sided breast cancer was to lower the cardiac toxicity attributed to the combination of IMNI and anthracyclines. The effect of IMNI was more pronounced in patients at high risk of internal mammary node metastasis (hazard ratio, 0.76; P 5 .001). In the days of sentinel node biopsies and lymphoscintigraphies, we believe that these impressive results could be improved even more if IMNI were administered only to patients with proven metastatic internal mammary nodes. For that reason, we routinely perform internal mammary sentinel node biopsies for patients with lymphatic drainage to the internal mammary chain, thereby selecting the specific subgroup for which additional IMNI should be added and minimizing morbidity associated with the treatment. We have demonstrated 2 that this tailored approach to the internal mammary chain can reverse the worse prognosis associated with lymphatic drainage to those nodes. 3
Controlled, dose-response study of sertindole and haloperidol in the treatment of schizophrenia. Sertindole Study Group
Authors: D L Zimbroff, J M Kane, C A Tamminga, D G Daniel, R J Mack, P J Wozniak, T B Sebree, B A Wallin, K B Kashkin
Journal: American Journal of Psychiatry (1997)

This multicenter, double-blind, placebo-controlled study evaluated the efficacy and safety of three doses of sertindole (12, 20, and 24 mg/day) and haloperidol (4, 8, and 16 mg/day) in the treatment of psychotic symptoms for 497 hospitalized patients with schizophrenia.The patients were randomly assigned to one of the medication groups and received treatment for 8 weeks. Changes in Positive and Negative Syndrome Scale, Scale for the Assessment of Negative Symptoms, Brief Psychiatric Rating Scale, and Clinical Global Impression scores were used as evaluations of treatment efficacy. Three rating scales were used to assess extrapyramidal symptoms as well as the occurrence of adverse events and the use of medications related to extrapyramidal symptoms.Both sertindole and haloperidol were comparably effective in the treatment of psychosis, and all dose levels were significantly more effective than placebo. For the treatment of negative symptoms, only sertindole, 20 mg/day, was significantly more effective than placebo. For all extrapyramidal symptom measures, sertindole was clinically and statistically indistinguishable from placebo, and rates of extrapyramidal symptoms were not dose related. All dose levels of haloperidol produced significantly more extrapyramidal symptoms than placebo or sertindole. Adverse events associated with sertindole treatment were mild in severity.Sertindole is a new antipsychotic agent effective for the treatment of both the positive and negative symptoms of schizophrenia, with motor side effects that are indistinguishable from those associated with placebo.
Correlates of psychiatric distress among wives of hemophilic men with and without HIV infection
Authors: M A Dew, M V Ragni, P Nimorwicz
Journal: American Journal of Psychiatry (1991)

The authors' objectives were 1) to examine symptoms of depression, anxiety, and anger-hostility among the wives of men with hemophilia, a major risk group for AIDS, and 2) to identify psychosocial characteristics of the women and/or their husbands that were associated with elevated distress in the women.Thirty-six women married to men with hemophilia were studied; the husbands of 17 of these women were HIV-seropositive. The men were drawn from the population of adults with hemophilia residing in a 24-county region of western Pennsylvania. Measures of wives' psychiatric symptoms were obtained, as were measures in three psychosocial domains: predispositional sociodemographic characteristics, psychosocial stressors, and husbands' strategies for coping.The psychiatric symptoms of the women did not differ as a function of their husbands' serostatus or across subgroups defined according to stages of HIV infection or clinical severity of hemophilia. Instead, other factors--perceptions of personal risk of AIDS, husbands' use of particular coping styles with respect to HIV infection, and the experience of other life events--were the principal correlates of psychiatric distress.HIV infection acted primarily as an indirect source of stress for these women, mediated by other psychosocial characteristics of both the women and their HIV-seropositive husbands. Mental health interventions for caregivers of HIV-seropositive individuals should target the identified psychosocial correlates of psychiatric distress.