tbuckley/cabot-search huggingface dataset:
Auricular Cartilage Calcification and Adrenal Insufficiency
Authors: Heiko Uthoff, Peter Wiesli
Journal: New England Journal of Medicine (2011)

A healthy 60-year-old man presented to the emergency department with profound hypotension 1 day after sustaining a minor hand laceration with minimal blood loss. Physical examination revealed stiffness in both ears, and calcification of the ears was subsequently revealed on computed tomography (Panel A, arrows) and radiography (Panel B, arrows). The patient's hemodynamic status improved promptly after administration of antibiotics and glucocorticoids, and he recovered with support from the intensive care unit. Throughout his 20-day hospital stay, bacterial cultures remained negative. Subsequent detailed investigations showed adrenal insufficiency resulting from autoimmune hypophysitis, with isolated failure to secrete corticotropin. Long-term glucocorticoid-replacement therapy . . .
Abstract 3417: An in vivo functional screen to identify metastasis suppressor genes
Authors: Nirupa Murugaesu, Marjan Iravani, Damian Johnson, Aristotelis Antonopoulos, David Sims, Kerry Fenwick, Costas Mitsopoulos, Qiong Gao, Nick Orr, Marketa Zvelebil, Stuart Haslam, Anne Dell, Christopher Lord, Alan Ashworth, Clare Isacke
Journal: Cancer Research (2012)

Abstract Background When breast carcinomas remain confined to breast tissue, cure rates exceed 90% (http://seer.cancer.gov/csr/1975_2006/). However, if the cancer disseminates through the body, long-term survival decreases depending upon the extent of, and the sites of, colonisation Genes that control the different stages of the metastatic process need to be identified to better delineate the process, and to aid in the development of metastatic biomarkers and provide potential targets for the treatment of metastatic disease. Genetic screens, such as those that exploit RNA interference (RNAi), provide an unbiased approach to the identification of genes associated with a phenotype of interest. Although cell-based screens have been highly informative in identifying genes involved in tumour cell survival, migration and invasion, these in vitro approaches are largely unsuitable for interrogating the later stages of the metastatic process, in particular the processes of cell dissemination, tumour cell extravasation from the circulation and colonisation of secondary sites. Method Using the 4T1 mouse model an in vivo functional metastasis screen that integrates RNAi technology and massively parallel sequencing was implemented to rapidly discover and validate metastasis genes. Results Using this approach, 12 ‘hits’ that suppress tumour cell colonisation of the lungs were identified. 3 of the top 5 hits have been validated as novel metastasis suppressor genes in both mouse and human cell lines and further studies have been undertaken to elucidate the mechanism of action of the top hit. Critically, these findings are clinically relevant in primary breast cancers where there is a significant correlation between elevated expression levels of these suppressor genes and reduced frequency of metastatic events. Conclusion This study demonstrates the value of adopting an unbiased methodology to discover novel metastatic genes and establishes, for the first time, that an in vivo metastasis screen can be combined with next generation sequencing to identify novel components of the metastatic process. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3417. doi:1538-7445.AM2012-3417
Adverse events with non-anesthesiologist administration of propofol: what you see is what you get but getting (the right standard monitors) is how you see
Authors: Jeffrey White, Peter Draganov
Journal: Endoscopy (2016)

We congratulate Dumonceau et al. on their recently published guideline on non-anesthesiologist administration of propofol for gastrointestinal (GI) endoscopy [1]. This is a well-crafted treatise with excellent current literature references that support their statements and recommendations.
Nonchromaffin-Staining Functional Tumor of the Organs of Zuckerkandl
Authors: Albert Attia, Richard L. Golden, Herman Ziffer
Journal: New England Journal of Medicine (1961)

THE detection of pheochromocytoma has become increasingly facilitated in the last decade as the result of the introduction of simple tests that may be performed as routine procedures in the differential diagnosis of hypertension.1 The relation of tumors of the chromaffin system to both fixed and paroxysmal hypertension is well known. The great majority of these tumors involve the adrenal medulla although a small but significant number (5 to 10 per cent) are extra-adrenal and involve the sympathetic ganglions, organs of Zuckerkandl and other chromaffin tissue in normal and ectopic locations.2 The organs of Zuckerkandl in the adult constitute rests . . .
1038 DECREASE OF PLASMA VEGF LEVEL WITHIN 2 MONTHS AFTER SORAFENIB ADMINISTRATION PREDICTS TREATMENT EFFICACY AND PROGNOSIS IN PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA
Authors: K. Tsuchiya, Y. Asahina, M. Muraoka, K. Tanaka, Y. Suzuki, Y. Hoshioka, N. Tamaki, T. Kato, Y. Yasui, T. Hosokawa, K. Ueda, H. Nakanishi, J. Itakura, Y. Takahashi, M. Kurosaki, N. Izumi
Journal: Journal of Hepatology (2012)
DELAY TO HOSPITAL ADMISSION AND ACUTE CORONARY CARE IN THE ELDERLY AND IN THE VERY ELDERLY
Authors: Beatrice Ricci, Edina Cenko, Zorana Vasiljevic, Maria Dorobantu, Sasko Kedev, Olivija Gustiene, Mirza Dilic, Božidarka Kneževic, Davor Milicic, Olivia Manfrini, Lina Badimon, Raffaele Bugiardini
Journal: Journal of the American College of Cardiology (2016)
US budget bill includes modest boost to NIH funding
Authors: M. McCarthy
Journal: BMJ (2014)

The US House of Representatives passed a compromise appropriations bill last week that partly restores funding to the National Institutes of Health (NIH), which had been hit hard by the 2013 sequester.1

Nonetheless, advocates for greater federal investment in biomedical research said that the bill’s increases fell far short of what was needed.

“The proposed package won’t adequately reverse the damage done by last year’s budget sequester and ensure the nation’s biomedical research enterprise makes continued …
FRI0239 Arthritis complicated with kawasaki disease is not TNF-alpha-dependent
Authors: T. Kizawa, T. Nozawa, T. Kanetaka, T. Hara, M. Kikuchi, R. Hara, T. Miyamae, T. Imagawa, M. Mori, S. Yokota
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> Around 10% of children with Kawasaki disease are still refractory to IVIG, and infliximab, anti-TNF-alpha monoclonal antibody, will be successfully administered as the second line of the treatment for these cases. We investigate whether or not TNF-alpha is responsible for the induction of arthritis in Kawasaki disease. <h3>Objectives</h3> To investigate the number of children and the characteristics of arthritis of Kawasaki disease following infliximab treatment. <h3>Methods</h3> Among 29 children (2005-2011) with Kawasaki disease who were refractory to IVIG (2 g/kg/day), and treated with infliximab (5 mg/kg), five were complicated with arthritis. The number of arthritis in other intractable children to IVIG was 0 out of 21 children treated with additional IVIG, and 1 out of 10 treated with plasma exchange. The clinical characteristics of arthritis treated with infliximab were investigated retrospectively and the arthritis was examined by musculoskeletal ultrasonography. <h3>Results</h3> Arthritis in one child was found early in Day 4 after the disease onset, and arthritis in other 4 children developed later in Day 18–24. Two children affected more than 5 joints including knee and hip joints, and 3 had arthritis on 4 or less joints. The mean titers of MMP-3 levels were high in those with active arthritis (205.5 ng/mL). The affected joints in all the children treated with TNF-alpha were examined by ultrasonography to demonstrate synovial hypertrophy and power Doppler signal indicating active synovial inflammation. <h3>Conclusions</h3> Arthritis is sometimes concurrent with Kawasaki disease in the early or convalescent phase of the disease. Our findings indicated that the frequency of concurrent arthritis treated with infliximab, a recommended biologics for juvenile idiopathic arthritis (JIA), was relatively high, and that it was not efficacious against active arthritis in Kawasaki disease suggesting that the synovial inflammation complicated with the disease will be TNF-alpha-independent. We speculated that other proinflammatory cytokines such as IL-6 and IL-1-beta would be responsible for the induction of concurrent arthritis in Kawasaki disease as the same with systemic JIA. <h3>Disclosure of Interest</h3> None Declared
1025 HEPATIC ARTERIAL INFUSION OF CETUXIMAB FOR PATIENTS WITH ADVANCED HEPATOCELLULAR CARCINOMA (HCC)
Authors: G. Poggi, B. Montagna, P. Di Cesare, A. Riccardi, C. Teragni, E. Pozzi, E. Quaquarini, G. Bernardo
Journal: Journal of Hepatology (2012)
P152 SEQUENTIAL NUC THERAPY FOLLOWING PEGYLATED INTERFERON-ALPHA EXPOSURE RESTORES INNATE IMMUNE RESPONSES CONFERRING A TREATMENT ADVANTAGE OVER NUC MONOTHERAPY IN CHRONIC HEPATITIS B
Authors: U.S. Gill, D. Peppa, L. Micco, H.D. Singh, G.R. Foster, M.K. Maini, P.T.F. Kennedy
Journal: Journal of Hepatology (2014)
Late Postprandial Hypoglycemia Occurring in a Man with Established Diabetes Mellitus
Authors: Arthur H. Dube
Journal: New England Journal of Medicine (1962)

SPONTANEOUS hypoglycemia has been described by Seltzer, Fajans and Conn1 as an early manifestation of diabetes mellitus. Their original report was challenged by Smelo2 and later by Fabrykant3 because the diagnosis had been established in all cases by a glucose tolerance test only. The following case illustrates the phenomenon of late postprandial hypoglycemia occurring in a patient with well established symptomatic diabetes mellitus who has been followed for three years since amelioration of his diabetes.Case ReportP.L., a 35-year-old man, was admitted to Crouse–Irving Hospital, Syracuse, New York, on October 28, 1957, as a private patient of Dr. Judah . . .
SEGUIMIENTO DE POLIPOS ADENOMATOSOS SEGÚN LAS CARACTERÍSTICAS DE LA COLONOSCOPIA INICIAL: HALLAZGOS Y CUMPLIMIENTO DE LA VIGILANCIA ESTABLECIDA
Authors: A Miguel Peña, E Del Pozo Maroto, L Arias Rodriguez, G Rascarachi, M García Alvarado, L Vaquero Ayala, R Diez, S Vivas, J Espinel, JL Olcoz Goñi
Journal: Endoscopy (2010)

Objetivos: Evaluar las características de los pólipos de colon detectados y extirpados mediante colonoscopia y verificar si se realiza un adecuado seguimiento endoscópico en la práctica clínica, en función de los hallazgos y de los factores de riesgo.
Cardiac denervation and cardiovascular reactivity to psychological stress
Authors: P A Shapiro, R P Sloan, J T Bigger, E Bagiella, J M Gorman
Journal: American Journal of Psychiatry (1994)

This study investigated the mechanisms responsible for increases in heart rate and blood pressure during psychological stress, which are incompletely understood. Since cardiac transplant patients have denervated hearts, they provide a unique model for isolating central versus peripheral influences on the cardiovascular response to stress.The authors compared the responses to two laboratory stressors of 20 ambulatory heart transplant recipients and two groups of normal subjects, one whose ages were matched to the ages of the transplant patients (mean = 46 years) and one whose ages were matched to the ages of the heart donors (mean = 27 years). The three groups of subjects performed mental arithmetic and reaction time tasks.Heart rate increase during the mental arithmetic task was significantly attenuated in the transplant recipients. During stress, stroke volume increased in the transplant recipients but decreased in both groups of comparison subjects. The difference in age between the heart recipients and donors did not account for the difference in reactivity between the heart transplant patients and the normal subjects.Direct neural stimulation of the heart is more important than peripherally circulating factors in producing tachycardia during psychological stress. Cardiac but not vascular responses to psychological stress are altered by cardiac denervation.
Defibrillation time intervals and outcomes of cardiac arrest in hospital: retrospective cohort study from Get With The Guidelines-Resuscitation registry
Authors: Steven M Bradley, Wenhui Liu, Paul S Chan, Brahmajee K Nallamothu, Gary K Grunwald, Alyssa Self, Comilla Sasson, Paul D Varosy, Monique L Anderson, Preston M Schneider, P Michael Ho
Journal: BMJ (2016)

<b>Objective</b>&nbsp;To describe temporal trends in the time interval between first and second attempts at defibrillation and the association between this time interval and outcomes in patients with persistent ventricular tachycardia or ventricular fibrillation (VT/VF) arrest in hospital. <b>Design</b>&nbsp;Retrospective cohort study <b>Setting</b>&nbsp;172 hospitals in the United States participating in the Get With The Guidelines-Resuscitation registry, 2004-12. <b>Participants</b>&nbsp;Adults who received a second defibrillation attempt for persistent VT/VF arrest within three minutes of a first attempt. <b>Interventions</b>&nbsp;Second defibrillation attempts categorized as early (time interval of up to and including one minute between first and second defibrillation attempts) or deferred (time interval of more than one minute between first and second defibrillation attempts). <b>Main outcome measure</b>&nbsp;Survival to hospital discharge. <b>Results</b>&nbsp;Among 2733 patients with persistent VT/VF after the first defibrillation attempt, 1121 (41%) received a deferred second attempt. Deferred second defibrillation for persistent VT/VF increased from 26% in 2004 to 57% in 2012 (P&lt;0.001 for trend). Compared with early second defibrillation, unadjusted patient outcomes were significantly worse with deferred second defibrillation (57.4% <i>v</i> 62.5% for return of spontaneous circulation, 38.4% <i>v</i> 43.6% for survival to 24 hours, and 24.7% <i>v</i> 30.8% for survival to hospital discharge; P&lt;0.01 for all comparisons). After risk adjustment, deferred second defibrillation was not associated with survival to hospital discharge (propensity weighting adjusted risk ratio 0.89, 95% confidence interval 0.78 to 1.01; P=0.08; hierarchical regression adjusted 0.92, 0.83 to 1.02; P=0.1). <b>Conclusions</b>&nbsp;Since 2004, the use of deferred second defibrillation for persistent VT/VF in hospital has doubled. Deferred second defibrillation was not associated with improved survival.
AB0415 High expression of gitr in serum and labial salivary glands from patients with primary sjögren’s syndrome
Authors: M. Zhang, X. Gan, X. Feng, W. Tan, C. Lv, Y. Zhu, L. Gu
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> Glucocorticoid-induced TNFR-related (GITR) is a gene coding for a member of the TNF receptor superfamily. After activated by its ligand GITRL, GITR could influence the activity of effector and regulatory T cells, participating in the development of several autoimmune and inflammatory diseases included rheumatoid arthritis and autoimmune thyroid disease. We previously reported that serum GITRL levels are increased in SLE patients compared with healthy controls (HC)<sup>[1].</sup> Here, we tested the levels of GITR and GITRL in serum and labial salivary glands from patients with primary Sjögren's syndrome (SS), and investigated correlation of their expression levels with clinical and laboratory variables. <h3>Methods</h3> Serum GITR and GITRL levels in 30 primary SS patients and 30 healthy controls were measured by ELISA. Patients were assessed for clinical and laboratory variables. GITR and GITRL levels in labial salivary glands were detected by immunohistochemistry. <h3>Results</h3> Primary SS patients had significantly increased serum levels of soluble GITR and GITRL compared with controls [GITR:(5.65±3.43) ng/ml vs. (0.33±0.24) ng/ml, p&lt;0.001; GITRL:(10.90±7.60)ng/ml vs. (0.36±0.28)ng/ml, p&lt;0.001)]. Serum GITR and GITRL levels were positively correlated with IgG and ESR. More lymphocytes infiltration could be detected in SS patients compared to HC by Immunohistochemical analyses. Moreover, the expression levels of GITR in lymphocytic foci of the labial salivary glands from SS patients are higher than those in HC. However, GITRL expression was failed to be detected both in SS patient and HC. <h3>Conclusions</h3> High serum GITR and GITRL levels in SS patients were associated disease activity variables included IgG and ESR, and the expression of GITR was increased along with more lymphocytes infiltration in labial salivary glands, suggesting an important role of GITR and GITRL in the pathogenesis of primary SS pathogenesis. <h3>References</h3> Lei Gu, Lingxiao Xu, et al. Correlation of Circulating Glucocorticoid-Induced TNFR-Related Protein Ligand Levels with Disease Activity in Patients with Systemic Lupus Erythematosus. <i>Clin. Dev. Immunol.2012,2012:265868</i> <h3>Disclosure of Interest</h3> None Declared
Radiolabeled-Antibody Therapy of B-Cell Lymphoma with Autologous Bone Marrow Support
Authors: Oliver W. Press, Janet F. Eary, Frederick R. Appelbaum, Paul J. Martin, Christopher C. Badger, Wil B. Nelp, Stephan Glenn, Greg Butchko, Darrell Fisher, Bruce Porter, Dana C. Matthews, Lloyd D. Fisher, Irwin D. Bernstein
Journal: New England Journal of Medicine (1993)

Radiolabeled monoclonal antibodies recognizing B-lymphocyte surface antigens represent a potentially effective new therapy for lymphomas. We assessed the biodistribution, toxicity, and efficacy of anti-CD20 (B1 and 1F5) and anti-CD37 (MB-1) antibodies labeled with iodine-131 in 43 patients with B-cell lymphoma in relapse.Sequential biodistribution studies were performed with escalating doses of antibody (0.5, 2.5, and 10 mg per kilogram of body weight) trace-labeled with 5 to 10 mCi of 131I. The doses of radiation absorbed by tumors and normal organs were estimated by serial gamma-camera imaging and tumor biopsies. Patients whose tumors were estimated to receive greater doses of radiation than the liver, lungs, or kidneys (i.e., patients with a favorable biodistribution) were eligible for therapeutic infusion of 131I-labeled antibodies according to a phase 1 dose-escalation protocol.Twenty-four patients had a favorable biodistribution, and 19 received therapeutic infusions of 234 to 777 mCi of 131I-labeled antibodies (58 to 1168 mg) followed by autologous marrow reinfusion, resulting in complete remission in 16, a partial response in 2, and a minor response (25 to 50 percent regression of tumor) in 1. Nine patients have remained in continuous complete remission for 3 to 53 months. Toxic effects included myelosuppression, nausea, infections, and two episodes of cardiopulmonary toxicity, and were moderate in patients treated with doses of 131I-labeled antibodies that delivered less than 27.25 Gy to normal organs.High-dose radioimmunotherapy with 131I-labeled antibodies is associated with a high response rate in patients with B-cell lymphoma in whom antibody biodistribution is favorable.
Abstract 2785: Development program of patient tumor tissue bank to support the drug and target discovery.
Authors: Marc Hillairet de Boisferon, Francis Bichat, Caroline Mignard, Loïc Morgand, Lydia Blot, Corinne Venot, Ana Merino-Trigo, Patricia Vrignaud
Journal: Cancer Research (2013)

Abstract Background: The humanization of mice with various tissues named Chi-mice® aimed to reproduce the human situation to be more predictive than conventional models. Despite significant progress in identifying malignancy of cancer cells, a more detailed understanding of tumor generation is needed. Xenograft of tumor cells into immunodeficient rodents has constituted the major preclinical screen for the development of new drugs. These models have identified efficacious agents, but their chemosensitivity, genetic drift and clonal selection induced by cell culture have been part of the high attrition rate observed in the clinical development. Patient-derived tumor xenograft (PDX) obtained in xenografting fresh patient tumor samples in mice are reported as being more predictive to the clinical situation in maintaining the histopathology and molecular diversity of the patient tumors. Methods: The PDXs collection has been set up under ethical agreement with informed consent of patients. The patients have been screened for absence of HIV, HBV and HCV. The anonymized patient's clinical history and tissue banking (including normal tissue when available) are centralized in our internal biological resource center. Tumor samples were freshly implanted in nude or SCID mice. Results: PDX Passage 0 Passage 1 Take rate (%) Breast 152 10 6 Lung 18 7 39 Bladder 31 11 35 Liver 31 4 13 Stomach 17 7 41 Kidney 28 8 29 Pancreas 21 4 19 Prostate 57 5 9 Total 355 56 Xenograft Passage 0 Lymphoma Established model SCID mice 85 16 (19%) 19 (22%) Nude mice 270 0 (0%) 37 (14%) Cryopreservation of the PDX is performed at early passages allowing using these PDX only at low passage. The histopathology, EGFR, PSA, AR, HER, ER and PR statute for lung, prostate and breast carcinoma and tumor growth characteristics of these PDX are being performed. Lymphoma characterization was performed using immunohistochemistry (hCD20, m/hKi67). Lymphoma detection, probably related to EBV infection, leads to switch to nude mice for xenografting.Conclusion: To create a highly diversified panel of PDX, we organized a global process from multiple centers. These PDX are currently being used in preclinical development of new therapies and clinical positioning including biomarkers identification. Citation Format: Marc Hillairet de Boisferon, Francis Bichat, Caroline Mignard, Loïc Morgand, Lydia Blot, Corinne Venot, Ana Merino-Trigo, Patricia Vrignaud. Development program of patient tumor tissue bank to support the drug and target discovery. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2785. doi:10.1158/1538-7445.AM2013-2785