tbuckley/cabot-search huggingface dataset:
P17.65 * RADIO-CHEMOTHERAPY WITH TEMOZOLOMIDE IN ELDERLY PATIENTS WITH GLIOBLASTOMA. A MONO-INSTITUTIONAL EXPERIENCE
Authors: F. Pasqualetti, P. Ferrazza, P. Cocuzza, D. Delishaj, R. Morganti, G. Pasqualetti, L. Fatigante, M. Fabrini, F. Monzani
Journal: Neuro-Oncology (2014)

INTRODUCTION: In glioblastoma (GBM) elderly patients, the literature showed limited benefit of surgery and chemo-radiotherapy with temozolomide (TMZ). The aim of this retrospective study was to evaluate the response to radio-chemotherapy with TMZ in terms of toxicity, overall survival (OS) and time to progression (TTP) in patients treated at Pisa University Hospital since 2005 for GBM and aged more than 65 years. MATERIALS AND METHODS: This analysis was performed in a simple of 40 patients, 20 male and 20 female, mean age at diagnosis 71.2 years (65-81). Patients were treated with radiotherapy (60 Gy/30 fractions) and concomitant chemotherapy with TMZ followed by TMZ. In all cases KPS was greater than 70 without important comorbidities. RESULTS: Hematological toxicities related to treatment with TMZ and concomitant radio-chemotherapy were anemia G4 in 1 patient (2.5%) and G1-G2 in 5 patients (12.5%), leucopenia G4 in 1 patient (2.5%) and G1-G2 in 5 patients (12.5%), thrombocytopenia G3-4 in 6 patients (15.0%) and G1-G2 in 13 patients (32.5%) . One patient experienced a bone marrow aplasia that caused the death. The median TTP and the median OS of the entire cohort, from the date of diagnosis, were 10.6 months (6.7-14.4) and 19.3 months (17.8-20.7), respectively. No significance results for OS analysis were found for age at diagnosis and cardiovascular risk factors (diabetes and hypertension), as covariates, with a hazard ratio (HR) of 1.00 (95% C.I. 0.92-1.10) and 0.90 (95% C.I. 0.43-1.88) respectively. CONCLUSIONS: Considering the relative good toxicity profile and the efficacy of treatment, our experience supports the use of radio-chemotherapy with TMZ in the older class of population with GBM with good KPS and without important comorbidities.
Extracellular Volume Fraction for Characterization of Patients With Heart Failure and Preserved Ejection Fraction
Authors: Karl-Philipp Rommel, Maximilian von Roeder, Konrad Latuscynski, Christian Oberueck, Stephan Blazek, Karl Fengler, Christian Besler, Marcus Sandri, Christian Lücke, Matthias Gutberlet, Axel Linke, Gerhard Schuler, Philipp Lurz
Journal: Journal of the American College of Cardiology (2016)
Abstract 2489: A phase II trial of poly-ICLC in the management of recurrent or progressive pediatric low grade gliomas
Authors: Lisa R. Hartman, Donald L. Durden
Journal: Cancer Research (2012)

Abstract Low-grade astrocytomas and gliomas are the most common type of childhood brain tumor. Although children with low-grade gliomas often survive many years after conventional treatment with surgery and radiotherapy, there can be tremendous morbidity depending on the location of tumor and the effects of therapy. Newer forms of treatment with reduced side effects are much needed. We have designed a phase II trial to examine efficacy and safety of the biological response modifier poly-ICLC in children with low-grade gliomas, and to identify surrogate biomarkers for response to this agent. Poly-ICLC, a synthetic complex of polyinosinic and polycytidylic acid, stabilized with polylysine and carboxymethyl cellulose is a double stranded RNA (dsRNA) that is a ligand for the Toll-like Receptor 3 (TLR3), an important component of innate immunity. It has been shown to have direct antiviral and antineoplastic effects mediated by at least two interferon inducible nuclear enzyme systems of OAS and PKR. A previous Phase I/II trial of poly-ICLC conducted in pediatric patients with brain tumors (all histopathologic subtypes) suggested the low-grade glioma cohort had the best response to this therapy (50% PR rate). Additional clinical trials in adult patients have confirmed that the most responsive subgroup to poly-ICLC is low-grade glioma patients. We are currently conducting a multi-institutional phase II study of poly-ICLC administered at 20mcg/kg/dose intramuscularly twice weekly to children with recurrent or progressive low-grade gliomas. Simon's two-stage design will be used for statistical analysis. The primary goal of this study is determine the radiographic response rate. We will also characterize toxicity and determine if surrogate markers of tumor response and progression can be identified in patient serum, peripheral blood mononuclear cells (PBMC), and/or cerebrospinal fluid (CSF). To date, 4 pediatric subjects (ages 2-15) with recurrent low-grade gliomas have enrolled in the study. Poly-ICLC therapy has been well tolerated and none of the subjects have shown radiologic or clinical progressive disease. These results suggest that poly-ICLC may have a beneficial role in children with low-grade gliomas while minimizing treatment side effects. We have begun analyzing blood and CSF samples to attempt biomarker identification and correlation with subject responses, in hopes to yield a basis towards stratification and personalized therapy with recurrent disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2489. doi:1538-7445.AM2012-2489
Abstract 4256: Use of short tandem repeat profiling for authentication of human cell lines
Authors: Thomas M. Reid, Keen Wilson, Christopher Kraemer, Michael Baird
Journal: Cancer Research (2012)

Abstract Human cell lines are widely used in biological and biomedical research, and accurate data interpretation depends on unambiguous identity of a cell line relative to its original source. Contamination and misidentification of human cell cultures has been identified as a long-standing issue within the scientific community, and steps are now being taken to address the problem. Short-tandem-repeat (STR) DNA profiling provides an accurate, reliable, and standardized method for authentication of human identity. Currently, the ATCC is considering proposed standards for cell line authentication utilizing human STR typing, and many journals (including all AACR published journals) have adopted the NIH-recommended policy to mandate cell line authentication as a requirement for publication. Here we demonstrate the validation and use of two different STR systems to authenticate human cell lines as well as detect contamination by mouse feeder cells and other human cell lines. Threshold levels for detection of complete profiles as well as contamination are compared between the systems, and typical typing issues specific to cell lines are discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4256. doi:1538-7445.AM2012-4256
Resuscitations That Never End
Authors: Tessy A. Thomas, Laurence B. McCullough
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Food Allergies and Kissing
Authors: Rosemary Hallett, Lori A.D. Haapanen, Suzanne S. Teuber
Journal: New England Journal of Medicine (2002)

To the Editor: Peanuts and tree nuts are often the cause of fatal or nearly fatal allergic reactions induced by food.1,2 Accidental exposure through ingestion is common, but there are rare reports of transmission of allergens through kissing.3–5 We were recently surprised by the number of people in our data base of subjects with food allergies who spontaneously reported such reactions. Of 379 subjects with self-reported histories compatible with IgE-mediated food allergy to nuts or seeds, 20 (5.3 percent) reported reactions from kissing, although there was no direct query about this mode of exposure in our questionnaire. All . . .
Osmolar Renal Concentrating Ability in Healthy Young Men and Hospitalized Patients without Renal Disease
Authors: Robert D. Lindeman, H. Carmer Van Buren, Lawrence G. Raisz
Journal: New England Journal of Medicine (1960)

RENAL concentrating ability in response to an antidiuretic stimulus presumably is limited by a maximum urine osmotic pressure or osmotic urine-plasma gradient or ratio. Hence, the determination of urine and plasma osmolality by freezing-point depression in the hydropenic state or after vasopressin administration should make possible the precise measurement of the concentrating function. Nevertheless, reported "normal" values for maximal osmolar concentrating ability have varied over a wide range.1 2 3 4 Possible causes for this variation include the effect of dietary protein,5 previous state of hydration,2 , 6 small changes in solute excretion7 and changes in renal blood flow or filtration rate.8 9 10 In the present . . .
Effective hemostasis with double-balloon rectal catheter for uncontrolled bleeding during endoscopic mucosal resection of large rectal neoplasms
Authors: N. Matsui, X. Bai, D. Yoshimura, M. Sugi, A. Nakasha, A. Kuwano, Y. Shimokawa, K. Oogoshi, M. Tanaka, K. Nakamura
Journal: Endoscopy (2013)

Endoscopic mucosal resection (EMR) is a standard treatment for intramucosal colorectal neoplasms. Bleeding is one of the common complications of EMR [1] [2]. Bleeding is often stopped using hemoclips [3], soft coagulation with hemostatic forceps [4], and hypertonic saline–epinephrine injection [5], but it may be difficult to locate the bleeding vessel if the bleeding is continuous or massive.
Solitary and Multiple Adenomatous Polyps of the Gastrointestinal Tract
Authors: Stanley Mikal, Alexander J. Campbell
Journal: New England Journal of Medicine (1950)

EIGHTY-FIVE consecutive cases of solitary and multiple adenomatous polyps of the gastrointestinal tract at the Boston City Hospital have been reviewed.Solitary polyps were noted in 58 and multiple polyps in 27 cases. The ratio of solitary to multiple polyps was 2:1. Males were affected twice as often as females. Most of the polyps became manifest after the age of forty (62 cases). Eleven cases were observed in children under ten years of age, of whom 9 had solitary and 2 multiple polyps in the rectum. Dixon1 has observed 2 infants, each eighteen months of age, afflicted with multiple polyposis. . . .
AB0118 Physical Activity and Risk of Rheumatoid Arthritis in Women
Authors: D. Di Giuseppe, M. Bottai, J. Askling, A. Wolk
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Only one study has evaluated the association between exercise and risk of developing RA, showing no association [1]. <h3>Objectives</h3> To examine the association between physical activity and risk of developing rheumatoid arthritis (RA) in middle age and elderly women from the Swedish Mammography Cohort, a population-based prospective study [2]. <h3>Methods</h3> Data on physical activity were collected in 1997 by self-administrated food-frequency questionnaire (FFQ). Risk of RA associated with physical activity was estimated using Cox proportional hazard regression models. <h3>Results</h3> Among 30,112 women born between 1914 and 1948 followed-up from January 1, 2003 to December 31, 2010, 201 RA cases were identified (226,477 person-years). There was a statistically significant 35% lower risk of RA (relative risk (RR), 0.65; 95% confidence interval (CI), 0.43-0.96) among women in the highest category of leisure-time activity (combining more than 20 minute per day of walking/bicycling (median 40-60 minute per day) and more than 1 hour per week of exercise (median 2-3 hours per week)) as compared to women in the lowest category (less than 20 minute per day of walking/bicycling and less than 1 hour per week of exercise). A non-statistically significant decreased risk was observed for household work (-32%) and work/occupation (-15%), while an increased risk was observed for leisure-time physical inactivity (+27%). Daily energy expenditure was not associated with risk of RA. <h3>Conclusions</h3> This prospective population-based cohort study of women supports the hypothesis that physical activity can be a protective factor in the etiology of rheumatoid arthritis. Our results add to accumulated evidence on benefits of modifiable leisure-time physical activity for prevention of many other chronic diseases. <h3>References</h3> Cerhan JR, Saag KG, Criswell LA, Merlino LA, Mikuls TR: Blood transfusion, alcohol use, and anthropometric risk factors for rheumatoid arthritis in older women. J Rheumatol 29(2), 246-254 (2002). Harris H, Håkansson N, Olofsson C, Julin B, Åkesson A, Wolk A. The Swedish mammography cohort and the cohort of Swedish men: Study design and characteristics of 2 population-based longitudinal cohorts. OA Epidemiology 2013 Oct 01;1(2):16. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1737
Oral Contraceptives and Congenital Limb-Reduction Defects
Authors: Dwight T. Janerich, Joyce M. Piper, Donna M. Glebatis
Journal: New England Journal of Medicine (1974)

Exposure to exogenous sex steroids during pregnancy was investigated for 108 mothers of patients with congenital limb-reduction defects and 108 mothers of normal controls. Exposure resulted from pregnancy tests, supportive hormone therapy, and breakthrough pregnancies occurring while the mother was using oral contraceptives. Among mothers with malformed children, 15 (14 per cent) had a history of exposure; four (4 per cent) control mothers of normal children were exposed. Of the 15 exposed and affected children, the mothers of 11 had received orally administered hormones. The sex ratio of the nonexposed children was not exceptional, but affected children with a history of exposure to orally administered hormones were all males. This association suggests that orally ingested progestins may have an effect on the developing fetus that is sex-specific. (N Engl J Med 291:697–700, 1974)
AB0264 Low dose methotrexate protects rheumatoid arthritis bone mass against corticosteroid induced bone loss
Authors: B. Heidari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA)is an inflammatory arthritis associated with bone loss and subsequent osteoporosis (OP). Although anti-inflammatory effect of low- dose prednisolone (LP) exert some beneficial effect against bone loss but cumulative doses of LP predisposes RA patients to osteoporosis (OP). Treatment of RA with methotrexate reduces decrease activity and reduces the rate of bone loss. <h3>Objectives</h3> The present study aimed to compare the risk of OP in RA patients treated with LP alone versus patients received combination of MTX and LP. <h3>Methods</h3> One-hundred and three RA and 111 age-matched controls entered to study. Freqency of OP in the femoral neck (FN) and lumbar spine (LS) in 42 patients taking LP alone, 39 taking MTX+LP, 20 taking NSAIDs alone were compared with controls.In statistical analysis the risk of FNOP and LS OP was determined by calculation of adjusted odds ratio (OR) with 95% confidence interval (95%CI) after controlling for age and DD.ANOVA chi square and logistic regression analysis were applied using SPSS version 18 software. <h3>Results</h3> The mean age and mean disease duration (DD) of patients were 52±11.7 and 8.4±6.4 years and the mean age of control was 52±7.5 years. The Mean duration of treatment for three study groups were 46; 48; and 13 months respectively. Prevalence of FNOP in the study groups and controls was 28.9%; 54.8%; 50%,and 13.5% (P=0.001) and the prevalence of LSOP 15.4%; 28.6%; 20; and 12.6% respectively (P=0.12).In patients treated with LP the risk of FNOP compared with controls increased by OR=7.7 (3.4-17.5), versus 2.6 (1.07-6.3) in MTX +LP and 6.4 (2.2-17.9) in NSAD treated group. After controlling for age and DD the adjusted OR values decreased respectively to 4.07 (1.43-11.5); 1.2 (0.36-3.9); and 4.1 (1.2-13.8). The risk of LSOP after adjustment for age and DD decreased to nonsignificant levels in all groups. <h3>Conclusions</h3> These findings indicated that treatment of RA with LP alone significantly increase the risk of FNOP compared with nontreated patients and treatment with combination of MTX+LP excert a protective effect against corticosteroid-induced bone loss <h3>Disclosure of Interest</h3> None Declared
SAT0528 Role of Micrornas in Regulation of the Acute Inflammatory Response to Monosodium Urate Crystals
Authors: N. Dalbeth, B. Pool, C. Franklin, M.E. House, J. Cornish, D. Naot
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> MicroRNAs (miRNA) are a class of small, evolutionary conserved non-coding RNAs that function as posttranscriptional repressors of gene expression. <h3>Objectives</h3> To test the hypothesis that miRNA play a role in regulating gene expression of pro-inflammatory cytokines in response to MSU crystals. <h3>Methods</h3> We stimulated human monocytic THP-1 cells with monosodium urate (MSU) crystals and/or interleukin (IL)-1β, and examined miRNA and pro-inflammatory cytokine gene expression using quantitative real-time PCR. The effects of miR-146a over-expression were examined by transfecting THP-1 cells with miR-146a precursor. The relative expression of miR-146a was also examined in tophus samples and in peripheral blood mononuclear cells (PBMC) from people with intercritical gout, and normouricaemic and hyperuricaemic control participants. <h3>Results</h3> In THP-1 cells, MSU crystals increased miR-146a expression, but not other miRNA implicated in IL-1 regulation. miR-146a and IL-1β expression were both maximal 20 hours after MSU crystal stimulation. Culture with IL-1β alone led to an increase in miR-146a, but addition of IL-1β did not further increase miR-146a expression following culture with MSU crystals. Inhibition of IL-1β using IL-1ra did not inhibit MSU crystal induced miR-146a expression. Transfection of THP-1 cells with miR-146a precursor led to high levels of miR-146a expression and reduced MSU crystal-induced IL-1β, TNFα, MCP-1 and IL-8 gene expression. In people with intercritical gout, PBMC expressed higher levels of miR-146a, compared with both healthy normouricaemic and hyperuricaemic control participants (ANOVA p&lt;0.0001). Similar concentrations of IL-1β gene expression were observed in the three groups. Expression of miR-146a was also observed in tophus samples. <h3>Conclusions</h3> Together, these data suggest that miR-146a acts as a transcriptional brake in the acute inflammatory response to MSU crystals. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3400
Abstract 2715: Establishment of patient primary colorectal tumor xenograft models for test of anticancer agents.
Authors: Ning Zhang, Chunping Xu, Wen Wei Li, Wen Zhou, Yong Liu, Fang He, Rui Zhou, Changnian Liu
Journal: Cancer Research (2013)

Abstract BACKGROUND Human xenograft tumor models established by transplantation of human tumor cell lines into immunodifficient mice have been routinely used for preclinical test of anticancer agents. But tumor cell lines have a relatively low transplantability, which resulted in a limited number of tumor models available for selection right models to test novel anticancer agents. Recently, we have developed a large number of patients’ primary colorectal tumor xenograft models by transplanting human fresh colorectal tumor tissues into nude mice, which have been employed for preclinical test of standard care of drugs and novel anticancer agents for their chemosensitivity screening. METHODS The fresh colorectal tumor samples were collected from local hospitals. The tumor fragments of 2-3 mm were subcutaneously implanted in the flanks of nude mice by trocar needle. Sixteen tumor fragments were grafted into four mice from one patient tumor tissue (passage 0). The standard care of drugs as controls included 5-FU, irinotecan, oxaliplatin, Erbitux, and Avastin. The histopathology and gene sequencing of the established primary tumor models were analyzed and compared with patients’ original tumors. RESULTS A total of 180 patients’ colorectal tumor samples were implanted into nude mice; and 93 patient tumor derived models have been established with a tumor taking rates of 52% for the first passage. The tumor taking rates were higher in the later passages ranged from approximately 80-100%. The therapeutic efficacy of the test drugs was consistent with their clinical findings. The patients’ primary colorectal tumor xenografts from 5 passages retained a similarity in architecture, histopathological morphology, and genomic mutation status to the patients’ original tumors. CONCLUSIONS The patient primary tumor model system can provide a larger number of models for selection of right models to test novel agents in preclinical setting based on their anticancer mechanism. The primary tumor models retain a similarity in histology and genomic mutation status to their counterpart patients’ original tumors and may predict more relevant clinical response and higher correlation with clinical findings than use of traditional xenograft models established from long-term cultured cancer cell lines. Especially, they have advantages for test of target-oriented therapeutics in new drugs development programs. Citation Format: Ning Zhang, Chunping Xu, Wen Wei Li, Wen Zhou, Yong Liu, Fang He, Rui Zhou, Changnian Liu. Establishment of patient primary colorectal tumor xenograft models for test of anticancer agents. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2715. doi:10.1158/1538-7445.AM2013-2715