tbuckley/cabot-search huggingface dataset:
The Etiology of Multiple Sclerosis
Authors: C Confavreux, B Goudable, T Moreau
Journal: New England Journal of Medicine (1930)

The risk of developing Multiple Sclerosis is under the combined influence of environmental and endogenous factors, as shown by epidemiological and genetic studies. Immunological abnormalities are a salient feature of the disease but their myelinotoxic effect is still to be demonstrated. The pathogenesis of the disease remains unknown. The auto-immune theory as well as the infectious theory are arguable but they may, also, be both valid. Multiple sclerosis could be a post-infectious auto-immune disease, "final common way" of common childhood infections. Anyway, no infectious agent is demonstrable inside the central nervous system at the overt disease stage.
ERCP Pneumatic Injector
Authors: G. Sciarretta
Journal: Endoscopy (1985)

A new tool to aid radiation exposure prevention is presented. The ERCP pneumatic injector, which may be used by the endoscopist by actuating a foot-operated starting system, is capable of injecting the contrast medium at the desired flow and pressure, which can be adjusted during the examination. In this way, personnel radiation risk is eliminated.
Impact of BCR-ABL transcript type on outcome in patients with chronic-phase CML treated with tyrosine kinase inhibitors
Authors: Preetesh Jain, Hagop Kantarjian, Keyur P. Patel, Graciela Nogueras Gonzalez, Rajyalakshmi Luthra, Rashmi Kanagal Shamanna, Koji Sasaki, Elias Jabbour, Carlos Guillermo Romo, Tapan M. Kadia, Naveen Pemmaraju, Naval Daver, Gautam Borthakur, Zeev Estrov, Farhad Ravandi, Susan O’Brien, Jorge Cortes
Journal: Blood (2016)
Thymus-Derived Regulatory T Cells Are Positively Selected on Natural Self-Antigen through Cognate Interactions of High Functional Avidity
Authors: Elisa Kieback, Ellen Hilgenberg, Ulrik Stervbo, Vicky Lampropoulou, Ping Shen, Mario Bunse, Yarua Jaimes, Pierre Boudinot, Andreas Radbruch, Uwe Klemm, Anja A. Kühl, Roland Liblau, Nadine Hoevelmeyer, Stephen M. Anderton, Wolfgang Uckert, Simon Fillatreau
Journal: Immunity (2016)
Tibia and Fibula
Authors: Otto E. Aufranc
Journal: JAMA (1960)

Dr. J. H. Dimon: A 64-year-old barber was admitted to the emergency ward on February 7, 1959, after having fallen while drinking. There was no history of unconsciousness, and the patient was in generally good health. Physical examination was negative except for an obvious closed fracture (both bones) of the distal third of the tibia and fibula of the left leg. Circulation and neurological function in the foot were intact. The fracture was grossly unstable. The skin appeared in good condition. After a thorough over-all evaluation of the patient, the skin of the left leg was cleaned with alcohol, and a pillow splint was applied. The x-rays revealed a comminuted, oblique fracture at the junction of the middle and distal thirds of the tibia and an oblique fracture of the lower third of the fibula (Fig. 1). Dr. O. E. Aufranc: Dr. Rowe will open the discussion on the management
Role of Antibodies in the Specificity of Natural Cell-Mediated Cytotoxicity&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Mitsuo Takasugi, Donna Akira
Journal: JNCI Journal of the National Cancer Institute (1979)

Freshly isolated effector cells expressing natural cell-mediated cytotoxicity (NCMC) against cultured target cells possessed antibodies attached to Fc receptors on their cell surfaces. A wide variety of natural antibodies in the circulation combined with the receptors on effector cells to allow recognition of the many specificities on cultured target cells and resulted in reactions with an overall appearance of nonselectiveness. The role of antibodies in the specificity of NCMC was demonstrated by recovery of NCMC by trypsinized effector cells when incubated in serum. With absorbed serum, activity was selectively weaker against the absorbing target cell. When effector cells were reconstituted with antibodies eluted from the absorbing cells, selective cytotoxicity for that cell was detected. The specificity of effector cells reconstituted with eluted antibodies confirmed the results from previous studies on specificity by direct cytotoxicity and by competitive inhibition of cytotoxicity and supported the role of antibodies in NCMC.
Cancer Immunotherapy: Comprehensive Mechanism Analysis of Mesoporous‐Silica‐Nanoparticle‐Induced Cancer Immunotherapy (Adv. Healthcare Mater. 10/2016)
Authors: Xiupeng Wang, Xia Li, Kazuko Yoshiyuki, Yohei Watanabe, Yu Sogo, Tadao Ohno, Noriko M. Tsuji, Atsuo Ito
Journal: Advanced Healthcare Materials (2016)

A plain mesoporous silica (MS) nanoparticle without any immunomodulatory molecules enhances anti-cancer immunity in vivo. On page 1169, X.P. Wang, N. M. Tsuji, A. Ito and co-workers show that a plain MS nanoparticle promotes both Th1 and Th2 immune responses, and enhances the effector memory of CD4+ and CD8+ T cell populations in the three most important immune organs (bone marrow, lymph node and spleen) of mice.
Aggressive Non-Hodgkin Lymphoma: Predictive Value Of Sarcopenia and Skeletal Muscle Density On Prognosis With Rituximab Containing Therapy
Authors: Michael P Chu, Jessica Lieffers, Andrew R Belch, Neil Chua, Amelie Fontaine, Randeep Sangha, A. Robert Turner, Sunita Ghosh, Michael Sawyer
Journal: Blood (2013)
Abstract B2-48: Biological profile in invasive lobular carcinoma in medical oncology department, Algeria
Authors: Selma Sakhri
Journal: Cancer Research (2015)

Abstract Background: Invasive lobular cancers(ILC) constitute 5% - 15% of all invasive breast tumors, less common than invasive ductal carcinoma(IDC), and appear to have a distinct biology. The aim of our study is to determine the ILC biological profile collected in the department ofoncology medical Tizi Ouzou hospital Algeria Materials and Methods: We recorded the cases of 73 patients with ILC between January 2010 and January 2012. .the aim of this study is to evaluate the clinical and pathological response, molecular profiling using RE, RP, KI67, HER2, and the follow up between (2012 – 2014). Result: The average age of patients with ILC is 52 years, 40% women have postmenopausal status, all patients underwent mammography, diagnosed by a core needle biopsy, the commonest stage at presentation was stage III (42%).10 patients (13%) underwent a breast conserving surgery, and 87 % a mastectomy The majority of cases were histologic grade II (SBR II), 50% of the tumors were estrogen and progesterone receptor positive, Her2 neu was reported to be negative in 60 %. the treatment consisted on : neoadjuvant chemotherapy in 28 cases ( 38%) ,adjuvant chemotherapy in 42 cases (57%) , following by radiotherapy , and hormonal therapy ( HT) was given to 47 patients ( 64%) , and target therapy to 40% the follow up after 2 years , 12 % had metastatic or loco regional recurrence : bone ( 60%) , lung ( 30 %) , and liver in ( 10 %) , 88 % of the cases remain in complete remission. Conclusion: ILC are a heterogeneous group of tumors and the management decisions should be based on individual patient and biologic characteristic of the tumor. Citation Format: Selma Sakhri, Sr. Biological profile in invasive lobular carcinoma in medical oncology department, Algeria. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B2-48.
Neurobiology of panic disorder
Authors: C D Karkanias, G A Block, S Reines, J Bradwejn
Journal: American Journal of Psychiatry (1989)

Various provocative agents, including sodium lactate, carbon dioxide (CO2), caffeine, yohim- bine, serotoninergic agents, and cholecystokinin (CCK), have been utilized as panicogenics in studies on healthy volunteers as well as in panic disorder patients. An overview of the utilization of these agents to study the neurobiology of panic disorder is presented. The possible roles of several neurotransmitters and neuromodulators in the etiology of panic disorder and in the actions of drugs used in its treatment are also discussed. © 1998 Elsevier Science Inc.
A Validation of Current Prognostic Scores in Metastatic Colorectal Cancer (Mcrc) and a New Prognostic Score (A Gemcad Study)
Authors: V. Alonso-Orduna, M. Marmol, P. Escudero, A. Salud, M.J. Safont, J.C. Méndez, C. García Girón, M. Martín, C. Fernandez-Martos, X. García Albéniz, J. Feliu, J. Maurel
Journal: Annals of Oncology (2014)
Busulfan-Dose Escalation in Reduced Intensity Stem Cell Transplantation (RIC-HSCT) Results in Good Outcomes for Patients with MDS and AML without Increased Toxicity
Authors: Anita Sarma, Victoria T Potter, Jennifer Clay, Donal McLornan, Hugues de Lavallade, Kavita Raj, Judith C. W. Marsh, Austin Kulasekararaj, Antonio Pagliuca, Ghulam Mufti
Journal: Blood (2014)
Gender and duration of disease differentiate responses to rituximab–dexamethasone therapy in adults with immune thrombocytopenia
Authors: John Chapin, Christina S. Lee, Haiyu Zhang, James L. Zehnder, James B. Bussel
Journal: American Journal of Hematology (2016)

Adults often develop chronic immune thrombocytopenia (ITP) for which treatment order is uncertain. Rituximab and three cycles of dexamethasone (4R + 3Dex) improve treatment responses and short-term disease control but long-term outcome is not known. In adults with ITP treated with 4R + 3D, we sought long-term outcome and associated prognostic variables. Forty-nine adults treated at Weill-Cornell received 4R + 3Dex. Their clinical characteristics were reviewed. Duration was median time to treatment failure; Kaplan-Meier estimates were developed. Vbeta Tcell receptor (VBTCR) repertoire was obtained after treatment in 36 patients. Patients were adults with ITP 18-64 years old, median age 37. The 27 females were twice as likely to have an ongoing response to 4R + 3Dex (44.1%) as males (19.6%; P = 0.009). For ITP duration <12 months, 52.7% of patients had continuing responses to 4R + 3Dex compared to 15.3% of patients with diagnosis >12 months (P = 0.02). Females with ITP duration of <12 months had continuing responses in 78.6%, compared to males with <12 months duration of ITP (21.2%). For patients with disease duration <12 months, 67% of females had continuing responses, compared to 31% of males (P = 0.004). Post-treatment polyclonal VBTCR was seen in 9/10 continuing responders (six female, three male) but only 13/26 relapsers/nonresponders (P = 0.068). Durable remissions after treatment with 4R + 3Dex were more frequent in female patients with <12 months of ITP duration and those with polyclonal VBTCR after treatment, emphasizing the roles of duration of disease, gender and T cells in chronic ITP. Differences in pathophysiology of ITP by gender and by duration of ITP require further study. Am. J. Hematol. 91:907-911, 2016. © 2016 Wiley Periodicals, Inc.
Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model
Authors: Fiona C. Brown, Ashlee J. Conway, Loretta Cerruti, Janelle E. Collinge, Catriona McLean, James S. Wiley, Ben T. Kile, Stephen M. Jane, David J. Curtis
Journal: Blood (2015)
Reliability and validity of emotional blunting as a criterion for diagnosis of schizophrenia
Authors: J A Boeringa, S Castellani
Journal: American Journal of Psychiatry (1982)

The authors tested the usefulness of emotional blunting as a criterion for the diagnosis of schizophrenia on 130 patients with Research Diagnostic Criteria (RDC), diagnoses of schizophrenia, schizoaffective disorder, and affective disorder, using both a scale devised by Abrams and Taylor and a global item from the Schedule for Affective Disorders and Schizophrenia. Reliability for both measures was very high. The results did not support the use of emotional blunting as a value criterion for the RDC diagnosis of schizophrenia, although it may be useful in differentiating subtypes of schizophrenia and as an exclusion criterion for affective disorders. There was no advantage in using a scale rather than a single rating measure for assigning diagnoses.
Effects of human FLT3 ligand on myeloid leukemia cell growth: heterogeneity in response and synergy with other hematopoietic growth factors
Authors: W Piacibello, L Fubini, F Sanavio, MF Brizzi, A Severino, L Garetto, A Stacchini, L Pegoraro, M Aglietta
Journal: Blood (1995)
Communication With Family Caregivers in the Intensive Care Unit
Authors: Elie Azoulay, Nancy Kentish-Barnes, Judith E. Nelson
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The marriage of the "collapsible" man of prominence
Authors: H W Bird, P A Martin, A Schuham
Journal: American Journal of Psychiatry (1983)

The authors describe a clinical entity encountered in the treatment of marital disorders, the marital relationship of the "collapsible" man of prominence. They describe the presenting complaints of 16 prominent men seeking psychiatric treatment. They then discuss the individual personality characteristics of these men and their wives and their marital dynamics. They conclude that the marital relationship of men of prominence is a key determinant of their psychological functioning, and that a breakdown in this relationship results in dire consequences not only for the husband himself but for the community and institutions in which he lives and functions.
Short-Course Antiretroviral Therapy in Primary HIV Infection
Authors: Clara Lehmann, Christoph Wyen, Gerd Fätkenheuer
Journal: New England Journal of Medicine (2013)

BackgroundShort-course antiretroviral therapy (ART) in primary human immunodeficiency virus (HIV) infection may delay disease progression but has not been adequately evaluated. MethodsWe randomly assigned adults with primary HIV infection to ART for 48 weeks, ART for 12 weeks, or no ART (standard of care), with treatment initiated within 6 months after seroconversion.The primary end point was a CD4+ count of less than 350 cells per cubic millimeter or long-term ART initiation. ResultsA total of 366 participants (60% men) underwent randomization to 48-week ART (123 participants), 12-week ART (120), or standard care (123), with an average followup of 4.2 years.The primary end point was reached in 50% of the 48-week ART group, as compared with 61% in each of the 12-week ART and standard-care groups.The average hazard ratio was 0.63 (95% confidence interval [CI], 0.45 to 0.90; P = 0.01) for 48-week ART as compared with standard care and was 0.93 (95% CI, 0.67 to 1.29; P = 0.67) for 12-week ART as compared with standard care.The proportion of participants who had a CD4+ count of less than 350 cells per cubic millimeter was 28% in the 48-week ART group, 40% in the 12-week group, and 40% in the standard-care group.Corresponding values for long-term ART initiation were 22%, 21%, and 22%.The median time to the primary end point was 65 weeks (95% CI, 17 to 114) longer with 48-week ART than with standard care.Post hoc analysis identified a trend toward a greater interval between ART initiation and the primary end point the closer that ART was initiated to estimated seroconversion (P = 0.09), and 48-week ART conferred a reduction in the HIV RNA level of 0.44 log 10 copies per milliliter (95% CI, 0.25 to 0.64) 36 weeks after the completion of short-course therapy.There were no significant between-group differences in the incidence of the acquired immunodeficiency syndrome, death, or serious adverse events. ConclusionsA 48-week course of ART in patients with primary HIV infection delayed disease progression, although not significantly longer than the duration of the treatment.There was no evidence of adverse effects of ART interruption on the clinical outcome.(Funded by the Wellcome Trust; SPARTAC Controlled-Trials.com number, ISRCTN76742797, and EudraCT number, 2004-000446-20.
Endoscopic Mucosal Resection of Superficially Spreading Colonic Neoplasms Larger Than 5 cm in the Right Colon After Injection of Dilute Sodium Hyaluronate: Report of Two Cases
Authors: M Mukai, I Ito, S Mukoyama, Y Okamoto, M Sugimoto, K Tsuchiya, S Sato, H Nakasaki, H Makuuchi
Journal: Endoscopy (2003)

Submucosal injection is the most important procedure for the safe performance of endoscopic mucosal resection in the large intestine while avoiding the risk of perforation. We used dilute sodium hyaluronate containing Bosmin and achieved safe piecemeal resection of large superficial tumors in the right colon in two patients. Piecemeal snare resection is considered to be acceptable if all the tissue pieces can be collected for histopathological diagnosis.
Diabetic Gastroparesis
Authors: Michael Camilleri
Journal: New England Journal of Medicine (2007)

A 36-year-old man with a 20-year history of type 1 diabetes mellitus, background retinopathy, peripheral sensory neuropathy, and nephropathy presents with a history of several months of nausea and vomiting. On physical examination (performed 1 hour after the patient has eaten), his blood pressure is 130/80 mm Hg while he is lying down and 110/60 mm Hg while he is standing. His abdomen is not tender. There is epigastric distention, but no splash is audible when the upper abdomen is shaken. How should this patient be evaluated and treated?
Paths of Gene Action in Mammary-Tumor Development in Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Walter E. Heston
Journal: JNCI Journal of the National Cancer Institute (1946)

Journal Article Paths of Gene Action in Mammary-Tumor Development in Mice Get access Walter E. Heston Walter E. Heston principal geneticist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 2, October 1946, Pages 79–85, https://doi.org/10.1093/jnci/7.2.79 Published: 01 October 1946 Article history Received: 23 September 1946 Published: 01 October 1946
DNA Damage Response in Hematopoietic Stem Cell Ageing
Authors: Tangliang Li, Zhong-Wei Zhou, Zhenyu Ju, Zhao-Qi Wang
Journal: Genomics Proteomics & Bioinformatics (2016)

Abstract Maintenance of tissue-specific stem cells is vital for organ homeostasis and organismal longevity. Hematopoietic stem cells (HSCs) are the most primitive cell type in the hematopoietic system. They divide asymmetrically and give rise to daughter cells with HSC identity (self-renewal) and progenitor progenies (differentiation), which further proliferate and differentiate into full hematopoietic lineages. Mammalian ageing process is accompanied with abnormalities in the HSC self-renewal and differentiation. Transcriptional changes and epigenetic modulations have been implicated as the key regulators in HSC ageing process. The DNA damage response (DDR) in the cells involves an orchestrated signaling pathway, consisting of cell cycle regulation, cell death and senescence, transcriptional regulation, as well as chromatin remodeling. Recent studies employing DNA repair-deficient mouse models indicate that DDR could intrinsically and extrinsically regulate HSC maintenance and play important roles in tissue homeostasis of the hematopoietic system. In this review, we summarize the current understanding of how the DDR determines the HSC fates and finally contributes to organismal ageing.
Cortisol and Alzheimer's disease, II: Dexamethasone suppression, dementia severity, and affective symptoms
Authors: B S Greenwald, A A Mathé, R C Mohs, M I Levy, C A Johns, K L Davis
Journal: American Journal of Psychiatry (1986)

The course of Alzheimer's disease can be complicated by depressive illness, often presenting enigmatically. To determine whether the dexamethasone suppression test (DST) can help distinguish patients with coexisting dementia and depression from those with dementia alone, DSTs were conducted with 22 nondepressed Alzheimer's disease patients. Eleven patients were nonsuppressors. The nonsuppressors were older than the suppressors but did not differ in depression or dementia ratings. The 8:00 a.m. postdexamethasone cortisol level correlated with depressive symptoms. A relationship between severity of dementia and depressive symptoms was also demonstrated.
Neuroleptic malignant syndrome in 12 of 9,792 Chinese inpatients exposed to neuroleptics: a prospective study
Authors: M Z Deng, G Q Chen, M R Phillips
Journal: American Journal of Psychiatry (1990)

In a prospective study of an estimated 9,792 inpatients treated with neuroleptic medication at a large Chinese psychiatric hospital, 12 patients developed neuroleptic malignant syndrome. The estimated prevalence of neuroleptic malignant syndrome in these psychiatric inpatients was 1.23/1,000 (95% confidence interval = 0.63/1,000 to 2.14/1,000). Unlike other investigators, the authors found that young adulthood, nonschizophrenic illness, oral high-potency neuroleptics, and concurrent use of lithium were not important risk factors for neuroleptic malignant syndrome. However, depot fluphenazine decanoate, particularly if used without an antiparkinsonian agent, was a risk factor.