tbuckley/cabot-search huggingface dataset:
Mucoid<i>Escherichia coli</i>in Cystic Fibrosis
Authors: Ann B. Macone, Gerald B. Pier, James E. Pennington, Wallace J. Matthews, Donald A. Goldmann
Journal: New England Journal of Medicine (1981)

Patients with cystic fibrosis commonly harbor in their lungs strains of Pseudomonas aeruginosa that have a mucoid coating considered virtually pathognomonic for the disease. We found that strains of Escherichia coli with a morphologically similar mucoid coating were present in the respiratory tracts of eight (11.8 per cent) of 68 patients with cystic fibrosis whose sputum cultures yielded Esch. coli, as compared with none of 89 patients without cystic fibrosis who had Esch. coli in sputum. Mucoid strains of Esch. coli were also recovered from the stools of five (11.1 per cent) of 45 patients with cystic fibrosis, as compared with one (0.7 per cent) of 150 patients without cystic fibrosis. The mucoid substances purified from Esch. coli were biochemically and antigenically distinct from those of P. aeruginosa. We conclude that the respiratory tract in cystic fibrosis offers an environment conducive to the production of a mucoid coating not only by P. aeruginosa but by other gram-negative bacilli as well. (N Engl J Med. 1981; 304:1445–9).
Paranoia and platelet MAO in normals and nonschizophrenic psychiatric groups
Authors: R J Haier, D L Murphy, M S Buchsbaum
Journal: American Journal of Psychiatry (1979)

The authors compared the correlation between platelet monoamine oxidase (MAO) activity and the Paranoia (Pa) scale of the Minnesota Multiphasic Personality Inventory in several groups. The data suggest that there is a positive association between high MAO activity and high scores on the Pa scale but only in samples with psychopathology.
Opsonic Requirements for Intravascular Clearance after Splenectomy
Authors: Stephen W. Hosea, Eric J. Brown, Max I. Hamburger, Michael M. Frank
Journal: New England Journal of Medicine (1981)

We investigated the opsonic requirements for intravascular clearance of pneumococci in guinea pigs and of sensitized erythrocytes in human beings after splenectomy. The impaired clearance of injected pneumococci in splenectomized guinea pigs was corrected by immunization. This improvement in clearance was due to increased hepatic sequestration of organisms. There was a significant delay in antibody-mediated clearance of autologous erythrocytes sensitized with IgG (P < 0.001), although the rate of complement-mediated clearance in splenectomized patients was normal. A fourfold increase in sensitizing antibody resulted in a significant improvement in clearance that was due to increased hepatic sequestration (P < 0.005). One patient who had an intact spleen and who had previously received Thorotrast (thorium oxide) had impaired antibody-mediated clearance despite increased sensitization. These observations suggest that, after splenectomy the remaining macrophages of the reticuloendothelial system require increased amounts of antibody to mediate efficient intravascular clearance of opsonized particles.
Hospital at the Venice Biennale
Authors: Colin Martin
Journal: BMJ (2005)

T he Venice Biennale is a cultural Olympiad, where nations field their pre-eminent contemporary artists for judgment. Many countries have permanent pavilions in the city's public gardens. George Hadjimichalis has transformed Greece's terracotta brick pavilion into a hospital. The flags of the Red Cross and the Red Crescent fly above it, adding a timely political dimension by reminding us that the Geneva Conventions protect all hospitals.

“The hospital is a paradoxical space; it is within society and plays a very important in it, yet at the same time it is outside it,” says Hadjimichalis. “People change identity once they are admitted as patients or when they enter it as relatives or friends. As a space it is self referential rather than related with the outside world, so it is a closed circuit.” His four part, multimedia installation is …
The Clinical and Genetic Spectrum of the Holt-Oram Syndrome (Heart-Hand Syndrome)
Authors: Craig T. Basson, Glenn S. Cowley, Scott D. Solomon, Barbara Weissman, Andrew K. Poznanski, Thomas A. Traill, J.G. Seidman, Christine E. Seidman
Journal: New England Journal of Medicine (1994)

The Holt-Oram syndrome is an autosomal dominant condition characterized by skeletal abnormalities that are frequently accompanied by congenital cardiac defects. The cause of these disparate clinical features is unknown. To identify the chromosomal location of the Holt-Oram syndrome gene, we performed clinical and genetic studies.
The Course and Prognosis of Different Forms of Chronic Airways Obstruction in a Sample from the General Population
Authors: B Burrows, J W Bloom, G A Traver, M G Cline
Journal: New England Journal of Medicine (1987)

We examined the course and prognosis in subjects selected from the general population who had chronic airflow obstruction at the time of their enrollment in a longitudinal epidemiologic study. Mortality and the rate of change in lung function were analyzed in relation to the initial clinical characteristics of the subjects. Twenty-seven subjects with symptoms and signs of asthma (Group I) had a higher survival rate and a much lower rate of decline in pulmonary function than the 45 subjects in Group III, whose clinical characteristics were more compatible with an emphysematous form of chronic obstructive pulmonary disease (COPD). The 10-year mortality among subjects in Group III (non-atopic smokers without a history of asthma) was close to 60 percent, whereas it was only 15 percent in Group I (atopic subjects or nonsmokers with known asthma). The mean overall rate of decline in forced expiratory volume in one second was 70 ml per year in Group III but less than 5 ml per year in Group I. Forty-five patients (Group II) who did not clearly fit into either Group I or III had intermediate values for survival and decline in pulmonary function. Previous data on mortality from COPD and the rate of progression of the condition, although compatible with our findings in patients who had an emphysematous form of disease, are not applicable to those with an asthmatic-bronchitic form. Better control of the progression of asthmatic bronchitis with therapy may explain its more favorable prognosis.
Natural History of GBV-C/Hepatitis G Virus Infection Through the Follow-Up of GBV-C/Hepatitis G Virus–Infected Blood Donors and Recipients Studied by RNA Polymerase Chain Reaction and Anti-E2 Serology
Authors: Jean-Jacques Lefrère, Pascale Loiseau, Jacqueline Maury, Jacqueline Lasserre, Martine Mariotti, Nadine Ravera, Joelle Lerable, Guillaume Lefèvre, Laurence Morand-Joubert, Robert Girot
Journal: Blood (1997)
The outcome of ZBEAM, a regimen combining 90Y ibritumomab tiuxetan with high dose chemotherapy in elderly patients with non-Hodgkin’s lymphoma (NHL)
Authors: A. Y. Krishnan, A. Nademanee, S. J. Forman, H. Fung, A. Molina, D. Yamauchi, R. Spielberger, N. Kogut, A. Raubitschek
Journal: Journal of Clinical Oncology (2005)

6566 Background: Total body irradiation (TBI) has been a part of many transplant regimens for NHL due to the radiosensitivity of NHL. However, many older patients (pts) are not candidates for TBI due to its toxicity. In addition, non-radiation based autologous stem cell transplants(ASCT) in older pts have been unsuccessful due to high relapse rates. In order to reduce toxicity while utilizing the benefits of targeted radioimmunotherapy (RIT) we conducted a phase II study with 90Y ibritumomab tiuxetan(Zevalin) and high dose BEAM with ASCT in elderly pts with high risk NHL. Methods: Between 5/02 and 9/04, twenty-four pts were enrolled. Median age at transplant was 60 years. All patients had a CD20+ NHL, including 8 with Mantle Cell. Disease status included;3 with induction failure, 6 in first PR, 7 in 1st or 2nd relapse, 7 in high risk 1st CR, 1 in 2nd CR. Pts received a median of two prior chemotherapy regimens (range1–4). Fifteen pts had a positive PET scan prior to ASCT. All pts received a fixed dose of 90Y of 0.4mCi/kg on day-14. Dosimetry was not performed. Chemotherapy started on day-7 with Carmustine 150mg/m2 day-7,-6,Cytarabine 800mg/m2 and Etoposide 800mg/m2 day-5 through day-2, and Melphalan 140mg/m2 on day-1. A median of 4.5 X10 6 CD34+ cells/kg were reinfused on day 0. The median dose of 90Yadministered was 32mCi (range 20–40). Results: Toxicities were similar to high dose BEAM alone and included grade 3 pulmonary toxicity (n=3, 12%), Grade 4 hematologic toxicity (n=10, 42%). Engraftment was also similar to BEAM alone withWBC engraftment to granulocytes >500/ul at11 days (range 9–26) and platelet engraftment (>20,000/ul) at 13 days (range 8–24). With a median follow up of 13 months (range 1–30), overall survivals (OS) and progression free survivals (PFS) are 94% (95% CI. 83–100) and 74% (95%CI .52–96) respectively. The relapse rate is 21% (95% CI. 0–42). In conclusion, ZBEAM is a well tolerated and effective regimen for older pts undergoing ASCT for poor risk NHL. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration BioGen IDEC employee BioGen IDEC BioGen IDEC BioGen IDEC FDA
Relation of Kveim-Antigen Reaction to Lymphadenopathy
Authors: Harold L. Israel, Robert A. Goldstein
Journal: New England Journal of Medicine (1971)

Kveim tests in 37 selected patients with sarcoidosis demonstrated that a reaction could be related to persistent lymphadenopathy and not to duration or activity of illness. Fourteen asymptomatic patients with marked enlargement of the mediastinal and hilar lymph nodes of long duration all reacted strongly. Positive tests occurred in only three of 12 patients having disease of recent onset with minimal adenopathy, and in only one of 11 with active hepatic or cutaneous sarcoidosis and normal chest roentgenograms. The demonstration that the reaction is more closely related to lymphadenopathy than to granulomatosis led to tests in patients with lymph-node enlargement due to other diseases. Typical reactions were obtained in patients with chronic lymphatic leukemia, tuberculous adenitis, infectious mononucleosis and nonspecific cervical adenitis. The Kveim test appears to be an immunologic reaction associated with persistent lymphadenopathy of diverse causes.
Transient Acute Depression Induced by High-Frequency Deep-Brain Stimulation
Authors: Boulos-Paul Bejjani, Philippe Damier, Isabelle Arnulf, Lionel Thivard, Anne-Marie Bonnet, Didier Dormont, Philippe Cornu, Bernard Pidoux, Yves Samson, Yves Agid
Journal: New England Journal of Medicine (1999)

Continuous high-frequency stimulation of the basal ganglia was recently introduced for the treatment of patients with advanced Parkinson's disease.1 This treatment seems to be most effective when the electrodes are placed in the subthalamic nuclei.2,3 Among the 20 patients treated successfully by bilateral subthalamic stimulation at our center, 1 woman had transient acute depression when high-frequency stimulation was delivered to the left substantia nigra, 2 mm below the site where stimulation alleviated the signs of Parkinson's disease. We describe here the results of detailed studies of the induction of major, reversible depression in this woman. Case Report A 65-year-old . . .
Case 35-1991
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, P.B. Kelsey, C.C Compton
Journal: New England Journal of Medicine (1991)

Presentation of CaseA 59-year-old man was admitted to the hospital because of abdominal pain, constipation, and microscopic hematuria.The patient was in stable health until five or six days earlier, when constipation, abdominal pain, and anorexia developed. Four days before admission he took a cathartic that contained phenolphthalein, and the upper abdominal pain became almost continuous. On the next day he passed a stool that appeared normal. The pain shifted to the left lower part of the abdomen and increased in severity.Two days before admission the patient came to this hospital. On physical examination the temperature was 36.7°C. . . .
Drug-Induced Torsades de Pointes and Genetic Screening—Reply
Authors: Arjun Gupta, Ambarish Pandey
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Case 3-1969
Authors: Francis M. Ingersoll, Robert E. Scully
Journal: New England Journal of Medicine (1969)

Presentation of CaseA fifty-eight-year-old woman was admitted to the hospital because of weakness.She had been well until three months previously, when an infection believed to be due to a virus developed; a medication of unknown type was prescribed. At that time shakiness of the hands and loss of appetite occurred, and she became very withdrawn. During the three months before entry she lost 40 pounds in weight. She experienced episodes of shaking in bed and became more withdrawn. Several days before entry she was told by a physician that she was anemic; vitamin B12 was administered. The . . .
Natural course and clinical features of myxoid and round cell liposarcoma (MRCL) - a retrospective single center analysis
Authors: B. Mispelaere, R. Sciot, M. Debiec-Rychter, A. Wozniak, P. Wolter, H. Dumez, I. De Wever, I. Samson, F. Amant, P. Schöffski
Journal: Journal of Clinical Oncology (2007)

10066 Background and methods: MRCL, the 2 nd most common type liposarcoma, represents ∼10 % of adult soft tissue sarcomas. In most pts the karyotypic hallmark is t(12;16)(q13;p11), leading to fusion of CHOP and FUS genes and generation of a hybrid protein. MRCL has unique sensitivity to antineoplastic agent ET-743 (Yondelis, Trabectidin), which induces specific morphological change and long-lasting response. We made a retrospective analysis of MRCL cases in our center. Results: 33 pts had histological diagnosis of MRCL with a mean (mn) follow-up of 45 mo (range, 2–214). By karyotyping or FISH analysis CHOP-FUS fusion was present in 12 and CHOP-EWS in 2 pts. The mn age at diagnosis was 45 yrs (range, 18–71), male:female ratio 1:0.8. Frequent primary sites: lower limb (25), abdomen (5), retroperitoneum (2), neck (2). Stage grouping at diagnosis: IA (2), IB (6), IIA (5), III (14), IV (2), not known (NK) (4). 2 had distant spread, 9 metachronous metastasis with a mn interval of 24 mo (range, 5–84). Main sites involved: abdomen (5), lung (3), bone (3). Surgery was performed with curative intent in 26/28 pts (5 NK), R0 resection in 23. 17/28 pts are alive without disease (16 previously R0-resected). 6/28 are alive with disease, 5 died due to MRCL. Relapse after R0 resection occurred after a mn of 24 mo (range, 5–84). Radiotherapy was used in 15/28 (5NK) with neoadjuvant (1), adjuvant (13) or palliative (3) intent (total doses 50–66 Gy). Chemotherapy (CT) was given in palliative (11) or neoadjuvant (1) fashion, after a mn of 1.3 surgical interventions (range, 0–3). 1 st -line CT: doxorubicin- based combinations (7), single-agent doxorubicin (3), ET-743 (1). Best response: PR (5), NC (4), PD (1), NE (1). Mn duration of response was 6.3 mo (range, 1–15). 2 nd -line CT: ET-743 (3), other agents (4). Best response: CR (1), PR (1), NC (3), PD (1), NE (1), with mn response duration of 7 mo (range, 1–13). 2 had further CT (PR 1, SD 1). Conclusions: MRCL is a chemosensitive sarcoma with variable clinical course. Local treatment can be curative, but systemic spread is frequent. Pts may respond to conventional CT or new agents such as ET-743. To evaluate the relative value of systemic treatment we need randomized trials in this unique clinical setting. No significant financial relationships to disclose.
Medical Care for Injection-Drug Users with Human Immunodeficiency Virus Infection
Authors: Patrick G. O'Connor, Peter A. Selwyn, Richard S. Schottenfeld
Journal: New England Journal of Medicine (1994)

Injection-drug use has become an important risk factor for infection with the human immunodeficiency virus (HIV), and HIV infection has become well established among drug users in North America, Europe, South America, and Southeast Asia13. In the United States, approximately 34 percent of all the cases of the acquired immunodeficiency syndrome (AIDS) in adults have occurred either in injection-drug users or in their sexual contacts. The proportion of the AIDS epidemic that is related to injection-drug use has increased steadily over the past decade,2,3 and it is particularly high among women and ethnic minorities3. In addition, . . .
Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium
Authors: J L Gabrilove, A Jakubowski, H Scher, C Sternberg, G Wong, J Grous, A Yagoda, K Fain, M A Moore, B Clarkson, Herbert F Oettgen, Kirby Alton, Karl Welte, Lawrence Souza
Journal: New England Journal of Medicine (1988)

Original Article from The New England Journal of Medicine — Effect of Granulocyte Colony-Stimulating Factor on Neutropenia and Associated Morbidity Due to Chemotherapy for Transitional-Cell Carcinoma of the Urothelium
Management of Cocaine Abuse and Dependence
Authors: Jack H. Mendelson, Nancy K. Mello
Journal: New England Journal of Medicine (1996)

During the 20th century, there have been recurrent episodes of cocaine abuse in the United States that have achieved epidemic proportions.1 Although the total number of people using the drug has decreased in the past decade, cocaine-related biomedical and psychosocial problems remain a major public health problem in the United States and many other countries. The expanding list of cocaine-related toxic effects, acute and chronic, includes reproductive dysfunction, hepatic necrosis, and pulmonary disease.2 Abuse of and dependence on cocaine may also be associated with disorders of sexual function, sleep, anxiety, and mood, as well as with delirium and psychotic disorders. . . .
Current Outcome Of HLA Identical Sibling Vs Unrelated DONOR Transplants In Severe Aplastic Anemia : An EBMT Analysis
Authors: Andrea Bacigalupo, Gérard Socié, Rose-Marie Hamljadi, Mahmoud Aljurf, A Mashan, Slawomira Kyrcz-Krzemien, A Cybicka, H Sengeloev, Ali Unal, Dietrich Beelen, A Locasciulli, Carlo Dufour, Jakob R. Passweg, R Oneto, Judith Marsh
Journal: Blood (2013)
Treating Depression in Pregnancy
Authors: Elisabeth Robert
Journal: New England Journal of Medicine (1996)

Pregnancy is frequently thought of as a time of emotional well-being for women, but it does not protect them from mood instability. In fact, it is a risk factor for depressive illness, defined as a state of psychological pain with dysregulation of mood.It is generally agreed that drugs of any type should be taken during pregnancy only when the risks to the mother and the fetus of no treatment outweigh the risks of taking the drug. In the case of depressive illness, the risks of no treatment in a pregnant woman might be high when the woman is suicidal, . . .
Britney tears
Authors: Des Spence
Journal: BMJ (2007)

I shook my head at the cheapness of the clothes in the shopping centre and fretted over whether children halfway round the world had sweated to produce them. My daughter tugged my sleeve. “Has Britney gone bonkers?” she asked. Britney's shaved head lurched from every news stand. Tattooed and in drug rehab, what has become of one of my daughter's icons? “No, she's sick,” I replied, “and she will get better. Don't worry.”

Am I so short of ideas as to waste column space in this prestigious journal on the likes of Britney Spears, a washed-up teen diva? But Britney matters, because her life is mirrored in the lives of our own children: image obsessed, materialistic, and sexualised. Britney was a child star and had it all, fame and fortune beyond measure. An entourage of sycophants fawned on her and indulged her every whim—a modern day princess who all young girls might emulate. But Britney is just another victim of our new culture of celebrity. She was denied that most basic of needs, a childhood. Celebrity sets no boundaries, distorts friendships, and, worst of all, removes the need to compromise; they can neither love nor be loved. Is Britney just a disposable celebrity commodity?

But our own children are in trouble too. Society has become so child centred that we are unwilling to deny children any of their demands or to set boundaries. Children are living a dream childhood where they can have it all. Inevitably, however, hormones and adulthood come knocking at the door. Denied the opportunity to develop the coping skills they need as adults, their lives implode—and so beckon drugs, alcohol, sex, cutting. Our antidepressants and counselling are sticking plasters on their gaping wounds. There are Britneys in every street of the country.

The corporate greed that feeds this celebrity culture is corroding the welfare of all our children. The seemingly harmless array of gossip magazines and tabloid newspapers are nothing more than tasteless voyeurism, observing the subjects' rise to fame but salivating at the spiral of decline—the obesity, cellulite, drugs, affairs, divorce, drugs busts, self loathing, agoraphobia, and then even worse.

We are all responsible for Britney's troubles. I am sorry that the world is so devoid of the decency to give her privacy, and I hope she finds some contentment. We doctors are hiding in a dugout in the comfort zone of scientific medicine, so often of questionable benefit, so that we have lost sight of wider problems in society. Perhaps it is time to look over the edge and see the devastation that childhood is becoming, time to teach our children that fame and fortune are false deities, both corrupt and malevolent. Removing the television sets, the internet, and pernicious magazines from our children's bedrooms might be a good start in limiting the influence of our celebrity culture. We may fret about the conditions of children in poor countries, but we have real problems closer to home too.