tbuckley/cabot-search huggingface dataset:
AB0375 Compare Hand Function at Rheumatic Arthritis and Osteoarthritis
Authors: N. Yesilmen, A. Gulkesen, G. Alkan, A. Kaya, G. Akgol
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) and Osteoarthritis (OA) is commonly observed in society and chronic diseases that affect hand functions. Both diseases affect daily living activities, such as dressing, nutrition, writing. Quality of life is impared by these diseases. Hand involvement and functions are of the most important factors that determine the impact of the diseases on daily living activities. <h3>Objectives</h3> The aims of this study is to compare hand function at rheumatic arthritis (RA) and osteoarthritis (OA), investigate the relationship between hand function, radiographic scores and other disease parameters in rheumatic arthritis and osteoarthritis patients and to evaluate disease activity effect on hand disability in RA patients. <h3>Methods</h3> Fifty six patients (47 women, 9 men) with RA and fifty one patients (47 women, 4 men) with hand OA were studied. Disease activity score 28 (DAS28) was calculated to evaluate disease activty in RA patients. Hand functions were assessed with hand grip strength, finger grip strength and Duruöz hand index at all patients. Physical function capacity was asssessed with Health Assessment Quastionnarie (HAQ), Rheumatoid Arthritis Quality of Life (RAQoL), Short Form-36 (SF-36) and Nottingham Health Profile (NHP) at all patients. Patients9 mood were assessed with Hospital Anxiety and Depression Scale (HAD) in both groups. Radiographic assessment of hands joints was evaluated according to the modified Larsen score and modified Sharp score in RA patient and Kellegren-Lawrence score in OA patients. <h3>Results</h3> There was statistically significant difference between the two groups in terms of hand grip strength. There was no statistically significant difference between the two groups in terms of generic and disease-specific measures in assessing health status and quality of life (excluding NHP fatigue, SF-36 general health, SF-36 vitality and SF-36 emotional role limitations). There was a significant correlation between Duruöz hand index, radiological scoring of joint damage and other clinical parameters in both groups. There was statistically significant difference between disease activity subgroups in RA patients in terms of hand functions. <h3>Conclusions</h3> Although RA causes severe deformities on hand joints, also hand osteoarthritis may impair hand functions as rheumatic arthritis. Hand osteoarthritis affects activity of daily living, so hand osteoarthritis may cause disability. <h3>Disclosure of Interest</h3> None declared
Allergic Reaction to Ginkgo Nut on FDG PET/CT
Authors: Eun Ji Han, Hye Lim Park, Sung Hoon Kim
Journal: Clinical Nuclear Medicine (2016)

We report the case of a 36-year-old woman who previously underwent total thyroidectomy for papillary thyroid carcinoma. F FDG PET/CT images demonstrated multiple lymph nodes with increased FDG uptake in the neck, chest, and abdomen and diffusely increased FDG uptake in the spleen, which were highly suspicious findings for malignant lymphoma. However, subsequent biopsy of axillary lymph node presented reactive hyperplasia. Detailed history revealed that the patient had a history of generalized edema and severe arthralgia after contact with ginkgo nut one week ago. This case highlights allergic reaction mimicking lymphoma on FDG PET/CT.
FRI0092 Quality or Life in RA Patients: Risk of Falls and Fractures (3-Year Prospective Study)
Authors: N. Toroptsova, A. Feklistov, O. Nikitinskaya, N. Demin
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To identify the frequency of falls, determine the fall-related risk factors and investigate the consequences of falls in RA patients during the 3-year prospective study. <h3>Methods</h3> 247 persons were enrolled: 133 RA patients (94% women; mean age 61±11) and 104 controls (96% women; mean age, 62±8). After a detailed clinical assessment (VAS, DAS28, HAQ) fall occurrence in the past 12 months before the enrolment was recorded and risk of falling was assessed by Short Physical Performance Battery (SPPB). Quality of life was measured by EQ-5D. Participants were followed up every 12 months during 3 years by telephone calls or visit to the clinic Outcome measures included fall occurrence, reason for fall, fall location, type and severity of injuries, fractures, use of health services. <h3>Results</h3> The fall prevalence during the preceding12-month period was 30.8% (41/133) in RA group and 19.2% (20/104) in control (p&lt;0.05). Frequency of fractures in the past was the same in two groups, but in RA patients they occurred at younger age than in controls (56±11 vs 65±13 years old, p&lt;0.05). PA pts achieved numerically worse results in performing SPPB test, especially in gait speed test and 5-time sit down-to-stand up test (p&lt;0.05) comparing to controls. Among RA patients fallers had significantly higher DAS28, VAS pain, received more high daily dose of glucocoticosteroids (p&lt;0.05). No differences were found in handgrip strength, number of swollen and tender joints of lower limbs, visual acuity. During 3-year follow up period 58 (43.6%) RA pts reported a total of 112 falls with an incidence rate of 42/100 prs-years and 44 (42.3%) controls – 98 falls (34/100 prs-years) (p&lt;0.05). Mean age of RA fallers was less than in control (59±9 vs 66±7, p&lt;0.05). 22 falls in RA pts and 8 – in control were resulted in fractures (p&lt;0.05). Quality of life was not restored throughout the year in RA pts with fractures, even after a wrist fracture vs control (p&lt;0.05). <h3>Conclusions</h3> Adults with RA are at high risk of falls and fall-related fractures that reduce the quality of there life. Falls have to be assessed regularly in medical consultations in RA patients regardless of age. RA patients are candidates for earlier preventing falls and fractures programs. <h3>Disclosure of Interest</h3> None declared
Epidemiology of anorexia nervosa in a defined region of Switzerland
Authors: J Willi, S Grossmann
Journal: American Journal of Psychiatry (1983)

The authors conducted a retrospective study of the incidence of anorexia nervosa in the industrialized canton of Zurich, Switzerland, during three randomly selected sampling periods from 1956 to 1975. The data were derived from case histories from nearly all medical, pediatric, and psychiatric clinics in this region. The incidence of anorexia nervosa increased significantly, from .38/100,000 for 1956-1958 to .55/100,000 for 1963-1965 to 1.12/100,000 for 1973-1975. This increase was not due to the fact that nowadays anorectic patients are hospitalized earlier or that they are hospitalized for less severe illness.
Statin use and the risk of herpes zoster: a nested case–control study using primary care data from the U.K. Clinical Research Practice Datalink
Authors: A. Matthews, M. Turkson, H. Forbes, S.M. Langan, L. Smeeth, K. Bhaskaran
Journal: British Journal of Dermatology (2016)

Statins are commonly prescribed worldwide and recent evidence suggests that they may increase the risk of herpes zoster (HZ).
Inefficiency of cisplatin plus 5-FU as second-or third line treatment in advanced breast cancer
Authors: I. Palacio, J.M. Buesa, F.J. Barón, R. López, J.F. Cueva, E. Esteban, E. Estrada, J.M. Gracia, A.J. Lacave
Journal: Annals of Oncology (1991)
Medicine, Public Policy and the Private Sector
Authors: James A. Shannon
Journal: New England Journal of Medicine (1969)

Abstract The development of a sound public policy for medicine requires awareness not only of the internal needs of the profession, but also of the economic and social pressures in areas of medical research, training and practice. Progress in correcting deficiencies in these areas has been halting and fragmentary; improvements have been urged, but their substantive nature not defined. Private organizations (the AMA, Association of American Medical Colleges, specialty groups) tend to have a limited outlook; whereas the instruments of government are subject to political pressures and the need for compromise. To provide the capability needed to deal with the broad problems of medicine and its interface with society, a new institution, a National Academy of Medicine, should be established. Such an Academy, independent but also associated with the National Academies of Science and Engineering, should serve effectively to guide policy and action in matters involving medical sciences, education and services.
PWE-087 Liver biopsy interpretative challenges – a four year tertiary centre review
Authors: A Paterson, M Allison, R Brais, S Davies
Journal: Gut (2015)

<h3>Introduction</h3> It is standard UK practice for all patients with a malignant diagnosis to have a multidisciplinary team (MDT) discussion as part of their management which includes a review of any histology. Studies have shown a discrepancy rate of 7–15% between the original and tertiary-centre histopathological diagnoses, although few have explored the impact of such a review for non-malignant pathologies. This study reviewed all liver biopsies referred to our centre, a university teaching hospital, to determine the (a) extent of agreement with the original report; (b) predicted clinical impact of interpretation differences; (c) major diagnostic challenges. <h3>Method</h3> All liver biopsies (n = 1333) for lesional and non-lesional assessments referred over four years, 2010–2013, were included. The majority came from ten local hospitals within our regional liver network. Liver resections and referrals for molecular assays only were excluded. The extent of agreement with the original diagnosis and probable impact on clinical management were recorded at the time of the review. A subset was explored in depth to determine more precisely the nature of interpretation differences. <h3>Results</h3> The majority of biopsies, 65%, were referred specifically for diagnostic advice; whilst 24% were as part of a transplant assessment or due to transfer of care; and 11% for MDT discussion. In 786 (59%) there was an interpretation difference, 528 (67%) of which were predicted to change management. Cases referred specifically for a diagnostic opinion were more likely to result in predicted management changes than those reviewed prior to an MDT or for other reasons, 45% vs 28% respectively, p &lt; 0.01. In over 70% of cases with architectural/vascular abnormalities, 64% with chronic biliary disease, and just over half where the major pathology was autoimmune hepatitis, (sub)acute hepatitis, or a benign mass lesion, specialist review would have changed management. Although agreement was better for chronic viral hepatitis, fatty liver disease and malignant lesions, in 24–36% of cases altered patient management was predicted post-review. The original and tertiary-centre histopathology reports for 107 biopsies with interpretation differences were reviewed. In 39 (36%) biopsies a definite or differential diagnosis was provided where the referrer had been uncertain; whilst In 38 (35%) cases an alternative diagnosis to the original report was made; and differences in fibrosis or inflammatory activity scoring were present in 25 (23%). The diagnostic challenge involved biliary disease in almost a third, 31%. <h3>Conclusion</h3> Non-specialists seek advice appropriately in challenging cases. A specialist pathology review may result in altered management in 40% of cases. Biliary disease is highlighted as a particular diagnostic challenge. <h3>Disclosure of interest</h3> None Declared.
Hysteria split asunder
Authors: S E Hyler, R L Spitzer
Journal: American Journal of Psychiatry (1978)

The authors present the proposed DSM-III classification of the traditional hysterical disorders, i.e., disorders that suggest physical illness but in which psychological factors are judged to be of importance. The use of the DSM-III inclusion and exclusion criteria--physical mechanism explains the symptoms, symptoms are linked to psychological factors, symptom initiation is under voluntary control, and there is an obvious recognizable environmental goal--are discussed in the differential diagnosis of somatoform disorder, factitious disorder, malingering, psychological factors affecting physical condition, and undiagnosed physical illness.
OP0095-HPR Men Living with Rheumatoid Arthritis – a Qualitative Study
Authors: B.A. Esbensen, K.V. Jensen, C.B. Jacobsen
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The prevalence for rheumatoid arthritis (RA) is 0,5 - 1,0% [1], rises with age and occurs more frequently in women with the ratio 3: 1 [2]. It is probably the reason why research has been focusing on women and knowledge about men is scarce. RA is strongly associated with patients experiences of physical, emotional, and social restrictions and quality of life is poor compared to the general population [3]. What is missing from the literature is how men with RA perceive, interpret and understand to live with a chronic illness. <h3>Objectives</h3> The aim of this study was to to develop an understanding of how men live with RA and their coping strategies to live with a chronic disease like RA. <h3>Methods</h3> A qualitative interview study was conducted based on individual semi-structured interviews. A purposive sample of 17 men with RA, (average age 58 (range 33-70)), diagnosed with RA on average 15 years previously (min. 5, max 34 years) were recruited from the rheumatology outpatient department, Glostrup Hospital. Semi-structured interviews were conducted to understand men9s experiences living with RA. The recorded interviews were transcribed verbatim, and analysed using Interpretive Description as described by Thorne [4] and by use of the Nvivo software. An interpretive description of the men9s experiences was established. <h3>Results</h3> The analysis revealed that men with RA are affected in several dimensions of their every daily life. Seven categories influencing men with RA were extracted: (1) Frame time of diagnosis, (2) Loss of bodily capacity, (3) Adapting to life with medicine, (4) Connecting to job situation, (5) Health literacy, (6) To navigate as a social individual and (7) The challenged to masculine rationality. <h3>Conclusions</h3> Study participants from a wide range of age and disease duration described their experience of living with RA as being related to essential issues about masculinity, social network and strategies to handle consequences of RA in everyday life. These findings demonstrate that RA has an impact on how men define themselves as partner and their masculine identity. Physical activity was highlighted as an important part of being a man. Knowledge from this study will be used in the planning of our subsequent intervention study targeted men with RA. <h3>References</h3> Scott, D.L., F. Wolfe, and T.W.J. Huizinga, Rheumatoid arthritis. The Lancet, 2010. 376(9746): p. 1094-1108. Alamanos, Y. and A.A. Drosos, Epidemiology of adult rheumatoid arthritis. Autoimmun Rev, 2005. 4(3): p. 130-6. Ovayolu, N., O. Ovayolu, and G. Karadag, Health-related quality of life in ankylosing spondylitis, fibromyalgia syndrome, and rheumatoid arthritis: a comparison with a selected sample of healthy individuals. Clin Rheumatol, 2011. 30(5): p. 655-64. Thorne, S., Interpretive Description 2008, Walnut Creek, CA: Left Coast Press. <h3>Disclosure of Interest</h3> None declared
Remote Consequences of Injuries of the Nerves and Their Treatment. An examination of the present condition of wounds received in 1863-65, with additional illustrative cases.
Journal: JAMA (1895)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Washington State Tumor Registry and Its Role in Problems Regarding Gastric Cancer and Cancer Research&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: H. Davis Chipps, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

The Washington State Tumor Registry and Its Role in Problems Regarding Gastric Cancer and Cancer Research Get access H. Davis Chipps, M. D. H. Davis Chipps, M. D. Department of Pathology, University of Washington School of Medicine, Seattle, Wash. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 439–441, https://doi.org/10.1093/jnci/10.2.439 Published: 01 October 1949
AB0142 Suppression of Collagen-Induced Arthritis in Mice by Fab Fragments of Arthritogenic Anti-Type II Collagen Monoclonal Antibodies
Authors: S. Yoshino
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Antibody Fab fragments (Fabs) maintain the ability to bind to specific antigens but lack the binding site for complement as well as the site for binding to receptors on immune and inflammatory cells that play a critical role in autoimmune diseases including collagen-induced arthritis (CIA) in mice. Therefore, CIA might be regulated by type II collagen (CII)-specific antibody Fabs. <h3>Objectives</h3> The present study was performed to investigate the effect of Fabs of arthritogenic CII-specific IgG2b (C2B-9 and C2B-14) monoclonal antibodies (mAb) on CIA and to define the mechanism underlying the suppression of the autoimmune joint inflammation by the Fabs. <h3>Methods</h3> To induce CIA, DBA/1J mice were immunized by subcutaneous injections of CII plus CFA into the base of the tail on days 0 and 21. Hybridomas producing C2B-9 and C2B-14 were established by fusing anti-CII antibody-producing spleen cells and myeloma cells. C2B-9 and C2B-14 Fabs were prepared by the digestion of the CII-specific mAbs with papain and injected i.p. on days -1 and 3. The effect of the Fabs on CIA was evaluated clinically, serologically, and histologically. <h3>Results</h3> Treatment with C2B-9 or C2B-14 Fabs alone failed to suppress CIA. In contrast, the combination of C2B-9 and C2B-14 Fabs significantly suppressed both the incidence and the severity of CIA. The suppression of CIA by the Fabs was associated with a decrease in CII-specific IgG in serum. Histologically, proliferation of synovium, infiltration of inflammatory cells including mononuclear cells, and destruction of cartilage and subchondral bone were diminished in C2B-9 and C2B-14 Fab-treated animals. In vitro studies revealed that the capture of CII by O2B-9 or O2B-14 Fabs prevented the subsequent binding of intact anti-CII polyclonal antibodies to the captured CII. <h3>Conclusions</h3> These results suggest that autoimmune inflammatory diseases such as rheumatoid arthritis might be specifically regulated by pathogenic mAb Fabs via the interference with autoantigen-intact autoantibody interaction by the fragments, resulting in the suppression of complement and immune/inflammatory cell activation. <h3>References</h3> Yoshino, S., et al., Br. J. Pharmacol., 161:1351-1360, 2010. Koobkokkruad, T., and Yoshino, S., et al., J. Inflamm., 8:31-37,2011. Yoshino, S., et al., Immunol., 141:617-627, 2014. <h3>Disclosure of Interest</h3> None declared
Observations on Vitamin B12 Absorption in Primary Pernicious Anemia during Administration of Adrenocortical Steroids
Authors: John W. Frost, Manfred I. Goldwein
Journal: New England Journal of Medicine (1958)

IT has been adequately demonstrated that the basic defect in pernicious anemia is failure of the mucosal cells in the fundal portion of the stomach to secrete intrinsic-factor substance. This factor is necessary for normal absorption of vitamin B12 from the small intestine. A few reports in the literature have shown suboptimal reticulocyte responses in patients with pernicious anemia in relapse receiving ACTH and cortisone.1 2 3 4 We have recently studied the effect of adrenocortical-steroid administration on the absorption of radioactive vitamin B12 in classic primary pernicious anemia utilizing the Schilling test, which measures the absorption of orally administered radioactive . . .
June 10, 1912: A Discussion on Syphilis, with Special Reference to (A) Its Prevalence and Intensity in the Past and at the Present Day; (B) Its Relation to Public Health, Including Congenital Syphilis; (C) the Treatment of the Disease: Opening Address, with special reference to the Prevalence and Intensity of the Disease in the Past and at the Present Day
Authors: Norman Moore
Journal: Journal of the Royal Society of Medicine (1912)
Paying Physicians for High-Quality Care
Authors: Muttucumarasamy Mahendran
Journal: New England Journal of Medicine (2004)

1910 n engl j med 350;18 www.nejm.org april 29, 2004 1999, nearly a third of all recognized pregnancies ended in abortion, either induced or spontaneous, yet only 4 percent of all maternal deaths during that time were associated with any type of abortion.3 Dr. Marchetti asks why dilatation and evacuation is not used to evacuate the uterus in the case of fetal death. In fact, the procedure is routinely used for that purpose. She also points out that the difference between the death of a fetus in utero, out of sight, and in full view during a destructive procedure is the degree to which the event offends our sensibilities. We agree. Michael F. Greene, M.D. Jeffrey L. Ecker, M.D.
<i>Echinacea angustifolia</i>in Rhinovirus Infections
Authors: Matthew Leach
Journal: New England Journal of Medicine (2005)

to the editor: The trial by Turner et al. (July 28 issue) 1 could have benefited from the inclusion of additional treatment groups with higher daily doses of echinacea. The dose equivalent of 900 mg of dried root derives from the German Commission E monograph for Echinacea pallida root, a different species from E. angustifolia. 2 E. angustifolia root is not officially approved and thus has no recommended dosage in Germany, owing to a lack of sufficient supporting data. The 1999 World Health Organization monograph on E. angustifolia root cites a 3-g daily dose, which is 330 percent of the dose used in this trial. 3 The 3-g daily dose is also recommended by the Canadian Natural Health Products Directorate. 4