IgG4-Related Disease in Monozygotic Twins: A Case Report
Authors: Aurélie Grados, Thibaud Vaysse, Mikael Ebbo, Franck Carbonnel, Nicolas Schleinitz
Journal: Annals of Internal Medicine (2017)

Letters17 January 2017IgG4-Related Disease in Monozygotic Twins: A Case ReportAurélie Grados, MD, Thibaud Vaysse, MD, Mikael Ebbo, MD, Franck Carbonnel, MD, PhD, and Nicolas Schleinitz, MDAurélie Grados, MDFrom Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France; Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France; and Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.Search for more papers by this author, Thibaud Vaysse, MDFrom Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France; Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France; and Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.Search for more papers by this author, Mikael Ebbo, MDFrom Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France; Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France; and Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.Search for more papers by this author, Franck Carbonnel, MD, PhDFrom Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France; Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France; and Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.Search for more papers by this author, and Nicolas Schleinitz, MDFrom Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France; Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France; and Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0122 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: IgG4-related disease is a recently recognized chronic inflammatory disorder (1, 2). It is characterized by infiltration of almost any tissue with CD4+ T-lymphocytes and many IgG4-positive plasma cells (>10 per high-powered field, with an IgG4–IgG plasmacyte ratio >40%). Infiltration may be organized into masses. Fibrosis is a leading characteristic and often includes obliterative phlebitis and elevated serum IgG4 levels. IgG4-related disease occurs more frequently in men older than 50 years. The pathogenesis is unknown. Genetic studies in Japanese patients with disease of the pancreas or salivary and lachrymal glands have shown some association with haplotypes, genes, or gene polymorphisms (3). ...References1. Wallace ZS, Deshpande V, Mattoo H, Mahajan VS, Kulikova M, Pillai S, et al. IgG4-related disease: clinical and laboratory features in one hundred twenty-five patients. Arthritis Rheumatol. 2015;67:2466-75. [PMID: 25988916] doi:10.1002/art.39205 CrossrefMedlineGoogle Scholar2. Ebbo M, Daniel L, Pavic M, Sève P, Hamidou M, Andres E, et al. IgG4-related systemic disease: features and treatment response in a French cohort: results of a multicenter registry. Medicine (Baltimore). 2012;91:49-56. [PMID: 22198501] doi:10.1097/MD.0b013e3182433d77 CrossrefMedlineGoogle Scholar3. Oguchi T, Ota M, Ito T, Hamano H, Arakura N, Katsuyama Y, et al. Investigation of susceptibility genes triggering lachrymal/salivary gland lesion complications in Japanese patients with type 1 autoimmune pancreatitis. PLoS One. 2015;10:e0127078. [PMID: 25985088] doi:10.1371/journal.pone.0127078 CrossrefMedlineGoogle Scholar4. Brito-Zerón P, Ramos-Casals M, Bosch X, Stone JH. The clinical spectrum of IgG4-related disease. Autoimmun Rev. 2014;13:1203-10. [PMID: 25151972] doi:10.1016/j.autrev.2014.08.013 CrossrefMedlineGoogle Scholar5. Casanova JL, Conley ME, Seligman SJ, Abel L, Notarangelo LD. Guidelines for genetic studies in single patients: lessons from primary immunodeficiencies [Letter]. J Exp Med. 2014;211:2137-49. [PMID: 25311508] doi:10.1084/jem.20140520 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France; Hôpital universitaire de Bicêtre, Université Paris Sud, Assistance Publique-Hôpitaux de Paris, le Kremlin Bicêtre, Paris, France; and Hôpital Timone, Assistance Publique-Hôpitaux de Marseille, Aix Marseille Université, Marseille, France.Acknowledgment: The authors thank Prof. Laurent Daniel for pathologic analysis of these cases.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0122. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThoracic manifestations of IgG4 ‐related diseaseA descriptive study of IgG4-related disease in children and young adultsPathophysiology of IgG4-related disease: A T follicular helper cells disease? 17 January 2017Volume 166, Issue 2Page: 153-155KeywordsBile ductsComputed axial tomographyFibrosisGenetic diseasesHuman leukocyte antigenMagnetic resonance imagingMonozygotic twinsPancreasPlasma cellsTwins ePublished: 17 January 2017 Issue Published: 17 January 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...