tbuckley/cabot-search huggingface dataset:
Abstract 3630: In vitro and in vivo antitumor activity of multi-tyrosine Kinase inhibitors in neuroblastoma
Authors: Raul Calero, Rosario Serrano, Laura Avendaño, Enrique Poblet, Alberto Ocana
Journal: Cancer Research (2010)

Abstract Background: Despite Neuroblastoma (NB) is a curable tumor in its early stages, high risk patients continue to have a bad prognosis and a poor survival. Tyrosine kinase receptors mediate proliferation and survival and have been associated with oncogenic transformation in many human tumour types including NB. Sorafenib and sunitinib are two multityrosine kinase inhibitors that have shown antitumor activity in some solid tumours, like renal cell carcinoma. Evaluation of approved multi TK inhibitors in NB is a main goal in order to identify novel therapeutic options of treatment. Methods: Here, we tested the antitumor activity of sorafenib and sunitinib, two multityrosine kinase inhibitors, in NB cell lines and in an animal model. To this end, we have used cancer cell lines and an in vivo xenografted mouse model. MTT proliferation, apoptosis assays, immunohistochemical analysis, and biochemical experiments were performed to investigate the molecular bases of the action of both compounds, of sunitinib alone, or of sunitinib in combination with standard chemotherapy. Results: Using a representative panel of NB cell lines, we report that sunitinib exhibits a potent antitumor activity in vitro (IC50 0.8-2.6 µM) and a better growth inhibition profile compared with sorafenib (IC50 0.5-5.2 µM). Sunitinib also shows a high therapeutic index, when tested in non-transformed cells, and is synergic at very low doses (0.1 µM) with chemotherapies used for the treatment of NB tumors. Mechanistically sunitinib inhibits several tyrosine kinase receptor proteins and the downstream PI3-AKT pathway. Administration of sunitinib to NB cells induces cell cycle arrest and stimulates apoptosis. In vivo xenograft studies revealed a significant antitumor activity of sunitinib compared with the control group in two types of cell lines (SH-SY5Y, P=0.02 and SK-N-BE, P=0.08). Sunitinib demonstrated an anti-angiogenic effect in vivo with a reduction of markers associated with angiogenesis (e.g. factor VIII). Conclusion: These results demonstrate the antitumor activity of sunitinib in NB tumors and support their further development in clinical studies alone or in combination with chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3630.
Abstract P1-01-20: Clinicopathlogic Analysis of Invasive Breast Carcinoma with Micropapillary Component
Authors: T Yamanaka, N Suganuma, A Yamanaka, I Kojima, S Nishiyama, T Mukaibashi, H Nakayama, H Matsuura, K Matsuzu, A Chiba, M Inaba, Y Rino, A Yoshida, S Shimizu, M Masuda
Journal: Cancer Research (2012)

Abstract Background: Invasive micropapillary carcinoma(IMPC) is a rare variant of invasive breast cancer that is associated with a high incidence of lymph node(LN) metastasis. But, the meaning of focal micropapillary component has not been fully elucidated. Methods: We retrospectively reviewed 88 invasive breast carcinoma cases with IMPC and focal micropapillary component. Results: Sixty-four cases had micropapillary component only in operative specimens, 18 cases had only in core-needle specimens, and 6 cases had in both. Sixteen were diagnosed as IMPC, and 72 cases had focal micropapillary component with other histological type of invasive breast carcinoma; 65 cases with invasive ductal carcinoma, 6 cases with mucinous carcinoma and one with metaplastic carcinoma. There was one male patient. Mean age was 56.5 years old. Median tumor size was 2.5 cm. Forty two (47.7%) cases were nuclear grade(NG)1, 16 (18.2%) were NG2 and 30 (34.1%) were NG3. Seventy eight cases (90%) were ERand/orPgR positive and 18.5% were HER2 positive. Six cases had distant metastasis at initial diagnosis. LN metastases were observed in 63.6% of all cases, and this high rate of LN metastasis could be seen even in small tumor group; 45.5% in cases with tumor equal or less than 2 cm. In the group of IMPC, 40.0% had LN metastasis, and 56.9% in cases with focal micropapillary component. There was no significant difference between IMPC and focal micropapillary component by univariate analysis(p = 0.055). Multivariate analysis of all cases showed that tumor size(&amp;gt;2cm)(p = 0.047), NG(1 vs 2&amp;3, p = 0.017), and lymphatic invasion(p = 0.001) were significantly associated with LN metastasis. No significant difference between IMPC and focal micropapillary component was showed by multivariate analysis also (p = 0.60). Hormone receptor status or HER2 status were also not correlated(p = 0.92, p = 0.27 respectively). Among female patients without neoadjuvant chemotherapy, sentinel lymph node biopsy(SLNB) were underwent in 38 cases, and 16 cases (42.1%) had positive sentinel lymph node(SLN). Fourteen patients underwent additional axillary dissection and 7 cases (50%) had non-SLN metastases. Among patients with SLNB, 12 patients had micropapillary component in needle biopsy specimens, and 6 (50%) cases had positive SLN. Conclusion: Our data showed very high rate of LN metastasis in patients with micropapillary component, and this tendency still exists in cases with only focal micropapillary pattern. High positivity of SLNB was observed in these groups, and our data suggests that the findings of micropapillary component in CNB specimen could be used as a predictor of SLN metastasis. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-20.
TEMPORAL TRENDS IN AND FACTORS ASSOCIATED WITH SINGLE VERSUS DUAL COIL IMPLANTABLE CARDIOVERTER-DEFIBRILLATOR LEADS: DATA FROM THE NCDR ICD REGISTRY
Authors: Sean Pokorney, Craig Parzynski, James Daubert, Donald Hegland, Paul Varosy, Jeptha Curtis, Sana Al-Khatib
Journal: Journal of the American College of Cardiology (2015)
Agreements Signed To Test Foods For Cancer Prevention
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Agreements Signed To Test Foods For Cancer Prevention Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Pages 1050–1052, https://doi.org/10.1093/jnci/83.15.1050 Published: 07 August 1991
Is local excision adequate for T1 rectal cancer? A nationwide cohort study from the National Cancer Database (NCDB)
Authors: Y. N. You, N. Baxter, A. Stewart, H. Nelson
Journal: Journal of Clinical Oncology (2005)

3526 Background: Despite the higher rates of local failure reported after local excision (LE) in single-institution studies, LE remains preferred for early-stage rectal cancer because of sphincter preservation and presumed perioperative advantages. The hypothesis that LE is associated with greater risks of local/regional failure but reduced perioperative mortality and morbidity than standard resection (SR) was tested using the NCDB. Methods: 5305 patients with pT1/pT2 pN0cM0 rectal cancer undergoing surgery were reported to the NCDB in 1994–1996. 1114 patients with pT1 tumors who received only surgical therapy formed the study cohort: 616 (55.3%) underwent LE; 498 (44.7%), SR. Institutional tumor registrars reported patient and tumor characteristics as well as follow-up data. P-values (two-sided) were computed using the Chi-square test. Local recurrence, time-to-treatment-failure(TTF), and survival rates were analyzed by the Kaplan-Meier method. Results: Factors associated with the choice of LE versus SR included: distal location (≤ 5cm of the anal verge; 58% vs 42%, p<0.001), small size (<1cm in diameter; 77% vs 23%, p<0.001), and the absence of co-morbidities (58.5% vs 42%, p=0.02). Tumor histological grade and patient age did not affect the choice of procedure. 30-day mortality and morbidity rates were significantly lower after LE vs SR (Table). Despite similar overall survival at 5 years, the local/regional tumor recurrence rates were significantly higher after LE versus SR (Table). These differences persisted through 8 years of follow-up, with 5-, and 8-year local recurrence rates of 12.7% vs 6.1% (LE vs SR, p=0.03), and 14.4 vs 9.5% (p=0.01) respectively. Conclusion: Patients considering LE for T1 rectal cancer may expect lower rates of perioperative morbidity and mortality, but are likely to face greater risks of local/regional tumor recurrence. For those treated with LE, long-term and vigilant oncological follow-up is essential. No significant financial relationships to disclose.
PREDICTION OF RACIAL DIFFERENCES IN SUB-CLINICAL VASCULAR DISEASE IN AFRICAN AMERICANS AND WHITES: COMPARISON OF THE FRAMINGHAM AND THE ATHEROSCLEROTIC CARDIOVASCULAR RISK SCORES
Authors: Jia Shen, Ibhar Al Mheid, Alanna Morris, Viola Vaccarino, Laurence Sperling, Gary H. Gibbons, Arshed Quyyumi
Journal: Journal of the American College of Cardiology (2015)
Abstract A60: Kras-transformed Caco-2 cells establish a 3-D model of colon cancer
Authors: Kirti Magudia, Aurelia Lahoz-Ruano, Alan Hall
Journal: Cancer Research (2011)

Abstract While Caco-2 cells derived from a human colorectal carcinoma have historically been used to study differentiated colonic epithelium in 2-D cultures, recent work has used a 3-D cell culture system to model epithelial morphogenesis. We describe here the use of 3-D Caco-2 cell cultures to model colon cancer progression. Caco-2 cells harbor APC, p53, and SMAD4 mutations, but are wild type for Kras, the most frequently mutated gene in colon cancer. Control Caco-2 cells seeded in extracellular matrix generate hollow, polarized structures after 10 days. In contrast, Caco-2 cells expressing oncogenic Kras form much larger and filled structures that lack a central lumen. Furthermore, Western blot analysis of protein lysates made from day 1 and day 10 control structures reveals a strong decrease in cyclin B, suggesting a reduction in the proportion of cells undergoing mitosis. Kras structures, however, maintain cyclin B levels, providing evidence of prolonged proliferation. Immunofluorescence of the apical marker aPKC and the tight junction protein Z0–1 shows that Kras structures have disrupted polarity. Interestingly, Kras-expressing Caco-2 cells do not invade through a matrigel-based matrix. Thus we will investigate which other factors cooperate with oncogenic Kras to promote tumor progression in addition to which pathways downstream of Kras contribute to this transformed acinar phenotype. As most colon cancer research is conducted either with cell lines in 2-D culture or in models, this 3-D model has the potential to provide both relevance to human tumors and ease of mechanistic inquiry. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A60.
A Controlled Trial of Aerosolized Ribavirin in Infants Receiving Mechanical Ventilation for Severe Respiratory Syncytial Virus Infection
Authors: David W. Smith, Lorry R. Frankel, Larry H. Mathers, Allen T.S. Tang, Ronald L. Ariagno, Charles G. Prober
Journal: New England Journal of Medicine (1991)

Although the antiviral agent ribavirin improves the course of lower respiratory tract disease in spontaneously breathing infants with respiratory syncytial virus infection, it is not known whether ribavirin can benefit infants with severe respiratory syncytial virus disease who require mechanical ventilation.
Metastatic Follicular Thyroid Carcinoma to the Kidney: A Case Report
Authors: LUISA GARCIA-SANCHIS, DIEGO LOPEZ-AZNAR, AMPARO OLTRA, ANTONIO RIVAS, JUAN ALONSO, JOAQUIN MONTALAR, ANTONIO MATEO
Journal: Clinical Nuclear Medicine (1999)

Clinically detectable well-differentiated metastatic thyroid cancer to the kidney is rare, with only 12 cases reported in the medical literature. The authors report a case of metastatic thyroid carcinoma to the kidney in a patient with widespread dissemination. She underwent total thyroidectomy, radical left nephrectomy, radioactive ablation with I-131, radiotherapy, and thyroid suppression therapy. Well-differentiated thyroid metastatic cancer can be amenable to treatment with successful long-term results.
SAT0282 C-reactive protein (CRP) polymorphisms and haplotypes influence serum CRP levels independent of disease activity (BASDAI) in ankylosing spondylitis
Authors: T.A. Claushuis, M.K. de Vries, I.E. van der Horst-Bruinsma, M.A. van der Weijden, I.M. Visman, M.T. Nurmohamed, J.W. Twisk, J.B. Crusius
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> C-reactive protein (CRP) levels are used more frequently for determination of disease activity in patients with Ankylosing Spondylitis (AS), but these levels do not necessarily reflect disease activity in each patient. <h3>Objectives</h3> We investigated whether CRP levels were influenced by common single-nucleotide polymorphisms (SNPs) and haplotypes in the <i>CRP</i> gene in AS patients. Additionally, we studied the relation between CRP levels and the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). <h3>Methods</h3> In this exploratory cross-sectional study, 189 unrelated anti-tumour necrosis factor naïve Dutch Caucasian AS patients were included and <i>CRP</i> SNPs rs2794521, rs3091244, rs1800947, and rs876538 were genotyped and haplotypes constructed. We used a multivariate linear and logistic regression model to investigate the relation between the SNPs and baseline CRP levels (mg/l), controlling for NSAID use, BMI, smoking, age, sex, and using the BASDAI to correct for disease activity. <h3>Results</h3> CRP levels were significantly positively correlated with the BASDAI (p=0.001). AS patients with genotype CA of the tri-allelic (C&gt;T&gt;A) SNP rs3091244 were associated with significantly higher CRP levels when compared with genotype CC (CA: 18.6 mg/l vs. CC: 8.3 mg/l; p=0.02). Heterozygous carriers of haplotype 5 (tagged by allele A of rs3091244) had a significantly higher odd when compared with non-carriers to have a CRP value &gt;10 mg/l (OR=2.9, 95%CI 1.0 to 8.3; p=0.05) in the multivariate regression model. <h3>Conclusions</h3> Certain CRP polymorphisms (SNP rs3091244 genotypes) and the haplotype tagged by allele A are associated with high CRP levels in AS, independent of the BASDAI and other confounders. Therefore, carrying distinct genetic variants might explain the lack of elevated CRP levels despite high disease activity in certain AS patients. This observation can be important to interpret disease activity scores that incorporate CRP levels, like the Ankylosing Spondylitis Disease Activity Score (ASDAS). <h3>Disclosure of Interest</h3> None Declared
SAT0387 Psychometric Characteristics of the Italian Version of the Revised Fibromyalgia Impact Questionnaire Using Classical Test Theory and Rasch Analysis
Authors: A. Ciapetti, F. Salaffi, F. Franchignoni, A. Giordano, P. Sarzi Puttini, M. Ottonello
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> The aim of this study was to perform a psychometric analysis of the Italian Fibromyalgia Impact Questionnaire Revised version (FIQR), using both classical test theory (CTT) and Rasch analysis (RA) in order to better analyze its construct validity and provide a rational basis for a possible improvement of its metric quality. <h3>Methods</h3> The study involved 503 patients with fibromyalgia (FM) (423 women and 80 men) with mean age of 51.3 ± 10.1 years (range 19-74) and mean duration of symptoms of 11.1 ± 8.7 years (range 1-30). All patients completed the Italian FIQR during their clinical visit. The translation and cultural adaptation process of the Italian FIQR followed the published guidelines and no local adjustments were made except for a slight adaptation of item 13 related to "energy". <h3>Results</h3> Factor Analysis revealed two salient dimensions: function (items 1-9) and symptoms (items 12-21). RA was thus performed on these two subscales. Rating scale diagnostics suggested collapsing the eleven rating categories of the scale into five. After combining these rating categories, RA showed that most items of each of the two subscales fitted the respective constructs to measure (MnSq 0.7-1.3). The reliability levels of the two subscales were higher than 0.80. <h3>Conclusions</h3> This study provides psychometric evidence of the reliability, internal validity andtwo-dimensional structure of the FIQR in a FM population. Our results support the useof two separate subscales for "function" and "symptoms", and provide a useful starting point for further refinement of the scale. <h3>Disclosure of Interest</h3> None Declared
Association of Cervical Cytomegaloviruses with Venereal Disease
Authors: M. Colin Jordan, Wyatt E. Rousseau, Gary R. Noble, John A. Stewart, Tom D. Y. Chin
Journal: New England Journal of Medicine (1973)

Parity, race, and use of oral contraceptive agents were not related to recovery of cytomegalovirus (CMV) from the cervix of 196 nonpregnant women, but CMV antibody was more prevalent among black women. Of 120 women examined because of suspected venereal disease, 16 (13.3 per cent) had cervical CMV infection, and seven (5.8 per cent) had cervical herpesvirus infection. Neither virus wag recovered from 76 women having routine examinations. CMV isolation and antibody were significantly more prevalent among those with documented past or active gonococcal infection, but CMV isolation did not correlate with the actual presence of Neisseria gonorrhoeae in the cervical secretions at the time of sampling. The study suggests, but does not prove, an association between cervical CMV infection and venereal disease in this population. (N Engl J Med 288:932–934, 1973)
OC-133 Artery first PPPD—clinical outcome and staging using a standardised pathology protocol
Authors: D J Malde, G Morris-Stifff, C Verbeke, A M Smith
Journal: Gut (2012)

<h3>Introduction</h3> With increased numbers of borderline locally advanced patients undergoing resection due to the acceptance of portal vein (PV) resection, early dissection of the superior mesenteric artery (SMA) allows definitive assessment of the tumour/SMA relationship and improved control when PV resection is required. <h3>Methods</h3> The lymph node yield, resection margins, morbidity and mortality data were compared between patients undergoing Artery first technique of pancreaticoduodenectomy (January 2009–December 2010) and previous resections (January 2000–December 2008). <h3>Results</h3> 42 resections were carried out using the artery first technique were age, sex and pathology matched with 182 previous resections. Although higher, the increase in the overall R0 resection margins (28.6% vs 36.3%, p=0.375) and the posterior resection margins (42.9% vs 36.3%, p=0.481) didn9t meet significance. The mean lymph node yield was significantly increased (19 vs 27, p&lt;0.05) but there was no significant difference in the post-operative morbidity and mortality rates between the two groups. The actuarial 1 and 2 year survival was 72% and 49.4% for earlier resections and 71.8% and 56.8% for Artery first PPPD respectively. The 1 and 2 year disease free survival was 65.2% and 47% for earlier resections and 67.6% and 64.4% for Artery first PPPD. <h3>Conclusion</h3> Artery first resection enhances the clearance at the SMA (a common site for R1 resection) with increased lymph node yield. The 2-year follow-up with Artery first PPPD shows a trend towards improving overall and disease free survival. <h3>Competing interests</h3> None declared.
P04.08 * PLASMA LEVELS AND TUMOR TISSUE RNA OF MMP2 AND MMP9 EXHIBIT SIMILAR DISTRIBUTION IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA (GB)
Authors: E. Tabouret, F. Boudouresque, E. Denicolai, M. Barrie, C. Boucard, P. Metellus, D. Autran, D. Figarella-Branger, L. Ouafik, O. Chinot
Journal: Neuro-Oncology (2014)

BACKGROUND: We have previously showed that a high MMP2, and to a lesser extend a low MMP9 plasma level were associated to a high response rate, a prolonged PFS and OS in recurrent GB treated with bevacizumab, but not with cytotoxic agents, (Tabouret and col. Neuro-Oncol 2013). In order to further explore the optimal timing of bevacizumab administration, we analyzed potential differences of MMP2/MMP9 plasma levels and tumor RNA in patients with newly diagnosed and recurrent GB. METHODS: Plasma was collected before radiotherapy in newly diagnosed GB patients (pts) (Pop ND) and in a distinct population of pts at the time of recurrence (Pop RD). MMP2 and MMP9 plasma levels were assessed using ELISA. In a third population with paired initial and recurrent GB tumor (Pop NDT and RDT respectively), MMP2 and MMP9 RNA were analyzed using quantitative RT PCR. Correlations were analyzed using the Mann Withney U test, the Spearman correlation and the T-test. RESULTS: MMP plasma levels were tested in 44 ND and 76 RD pts. Mean levels of ND and RD MMP2 levels were 196.4 pg/ml (± 9.6) and 218.2 pg/ml (± 9.6). Mean levels of ND and RD MMP9 levels were 365.4 pg/ml (± 50.7) and 302.0 pg/ml (± 34.9). No significant difference was observed between ND and RD plasma levels of MMP9 and MMP2. In ND pts, no correlation was found between MMP2 and MMP9 plasma levels, neither between these plasma markers and KPS or age. In NR pts, MMP2 and MMP9 plasma levels were inversely correlated (p < 0.001). Paired MMP9 and MMP2 RNA were available in NDT and RDT for 29 patients. No difference was observed between NDT and RDT expressions of MMP9 and MMP2. At initial diagnosis, MMP9 and MMP2 were 95.7-fold and 15.9-fold over-expressed compared with normal brain. At recurrence, MMP9 and MMP2 were 80.6-fold and 25.9-fold over-expressed. MMP2 and MMP9 RNA were correlated in NDT (p = 0.001) but not in RDT. CONCLUSIONS: In this retrospective study, the prebiomarkers of BEV activity, MMP2 and MMP9, did not show significant change between GB initial presentation and recurrence both for plasma levels and tumor RNA. These results may suggest that BEV could be similarly active for pts with newly diagnosed and recurrent GB. Adequate prospective studies are warranted.
Intermittent Coronary Occlusion in Acute Myocardial Infarction
Authors: David Hackett, Graham Davies, Sergio Chierchia, Attilio Maseri
Journal: New England Journal of Medicine (1987)

We performed continuous electrocardiographic ST-segment monitoring and serial coronary adenography in 45 consecutive patients presenting in the early stages of acute myocardial infarction. During cardiac catheterization, 28 episodes of arteriographically confirmed coronary reopening and subsequent reocclusion were observed in 16 patients before (3 episodes) and during (25 episodes) continuous intracoronary infusion of streptokinase. In addition, ST-segment monitoring demonstrated 12 episodes of spontaneous transient return of the ST segment to the base line in eight patients between the time of admission and the performance of coronary arteriography. During arteriographically documented reocclusion, intracoronary isosorbide dinitrate (2 mg) reestablished the patency of the coronary artery within one to two minutes in 14 of 28 episodes that occurred in 11 of 16 patients. After streptokinase infusion, intracoronary administration of isosorbide dinitrate was followed by dilatation of the infarct-related stenosis from a mean value (±SD) of 1.12±0.3 mm (58.1±12.1 percent) to 1.33±0.4 mm (51.6± 12.9 percent; P = 0.004). Spontaneous intermittent coronary recanalization and reocclusion resulting from a variable combination of thrombosis and vasoconstriction are frequent during the early phase of acute myocardial infarction. We propose that the combination of intracoronary streptokinase and isosorbide dinitrate may increase the rate of stable coronary recanalization. (N Engl J Med 1987; 317:1055–9.)