tbuckley/cabot-search huggingface dataset:
Radiotherapeutic Management of Malignant Tumors of the Vagina
Authors: P M CHAU
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 12-1981
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Warren E. Grupe, David L. Gang
Journal: New England Journal of Medicine (1981)

Presentation of CaseA seven-year-old girl was admitted to the hospital because of bloody diarrhea and oliguria.She was well until one week earlier, when vomiting and diarrhea developed, with a low-grade fever. Several days before admission the fever subsided, but the diarrhea became profuse, with grossly evident blood. Continued vomiting precluded the intake of fluids, and the patient became dehydrated and lethargic, with diminished urinary volume. One day before entry she was admitted to another hospital, where examination was negative except for evidence of dehydration and blood-streaked stools. She had lost 2 kg in weight during the week before . . .
Fatality and Severity of Firearm Injuries in a Denver Trauma Center, 2000-2013
Authors: Angela Sauaia, Eduardo Gonzalez, Hunter B. Moore, Kirk Bol, Ernest E. Moore
Journal: JAMA (2016)

Death rates provide an incomplete picture of the effect of firearm injuries.2][3] We studied temporal patterns of GSW-associated severity and mortality in a Colorado urban trauma center and of all trauma deaths occurring in its catchment area from 2000 to 2013.Methods | We queried the state-mandated trauma registry of a level 1 trauma center (Denver Health Medical Center, DHMC) for data on injuries, cause, and severity for all patients who died in the hospital, were hospitalized, or required more than 12-hour observation from 2000 to 2013.Throughout this period, the DHMC catchment area was Denver County.To assess injury deaths at the scene (vs in-hospital), we obtained all Denver County records of trauma deaths during the same period.The Colorado Multiple Institutional Review Board approved the study with a waiver of consent.Injury severity was quantified by the Injury Severity Score (ISS; range, 1-75), a score for multiple injuries. 4 Each single injury was assigned an Abbreviated Injury Scale (AIS; 1 = minor injury to 6 = lethal injury) score, with severe defined as a score higher than 2. The maximum AIS score from the 3 most severely injured body regions was squared
LMI-01DEVELOPMENT OF CLINICAL GUIDELINES FOR THE TREATMENT OF LOW GRADE GLIOMAS IN LOWER AND LOWER MIDDLE INCOME COUNTRIES – A SIOP PODC INITIATIVE
Authors: Laila Hessissen, Nisreen Amayiri, Naureen Mushtaq, Nongnuch Sirachainan, Yavuz Anacak, Dipayan Mitra, Anthony Figaji, Antoinette Schouten-van Meeteren, Michael Sullivan, Alan Davidson, Jeannette Parkes, Eric Bouffet, Simon Bailey
Journal: Neuro-Oncology (2016)
Effect of Cold Water Immersion on Burn Edema in Rabbits
Authors: A G SHULMAN, K WAGNER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Outbreaks linked to duodenoscopes: microbiological control should be improved
Authors: Philippe Saliou, Raoul Baron
Journal: Endoscopy (2015)

We read with interest the article by Verfaillie et al., which described an outbreak of Pseudomonas aeruginosa linked to duodenoscope design [1]. This represents a genuine problem emerging in the field of endoscopy, with outbreaks reported in both Europe and North America relating to duodenoscopes contaminated with carbapenem-resistant enterobacteriaceae (CRE) [2]. To date, the risk of nosocomial infection from endoscopes has been estimated to be low; however, the number of outbreaks reported seems to have increased in line with the spread of highly resistant bacteria such as CRE.
HG-18NOVEL OLIG2 INHIBITOR DEMONSTRATES PRE-CLINICAL EFFICACY IN PEDIATRIC GBM
Authors: Holly Lindsay, Yuchen Du, Mary Sobieski, Clifford Stephan, Lin Qi, Huiyuan Zhang, Sibo Zhao, Frank Braun, Mari Kogiso, Murali Chintagumpala, D. Will Parsons, Gordon Alton, Gregory Stein, Graham Beaton, Xiao-Nan Li
Journal: Neuro-Oncology (2016)
Images of Early Gastric Cancer
Authors: R.  Murai, J.  Fujisaki, T.  Gotoda, B.  J.  Rembacken, S.  Nimura, T.  Shimoda, T.  Matsumoto, A.  Chonan, A.  Okano, H.  Takakuwa, A.  Nishio
Journal: Endoscopy (2003)
A Review of Some Spontaneous Tumors in Noninbred Mice
Authors: Helen A. Horn, M. D., Harold L. Stewart, M. D.
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article A Review of Some Spontaneous Tumors in Noninbred Mice Get access Helen A. Horn, M. D., Helen A. Horn, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Stewart, M. D. Harold L. Stewart, M. D. Laboratory of Pathology, National Cancer Institute3, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 3, December 1952, Pages 591–603, https://doi.org/10.1093/jnci/13.3.591 Published: 01 December 1952 Article history Received: 07 March 1952 Published: 01 December 1952
Cancer Statistics, 1988
Authors: E Silverberg, J A Lubera
Journal: CA A Cancer Journal for Clinicians (1988)

The estimates of the incidence of cancer are based on data from the NationalCancer Institute's Surveillance, Epidemiology and End Results(SEER) program (1982â€"1984).Nonmelanomaskin cancer and carcinoma in situ have not been included in the statistics.Theincidence of nonmela noma skin cancer is estimated to be more than 500,000 Prepared by
Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells
Authors: Hannah H. Chen, Norman Händel, Joanne Ngeow, James Muller, Michael Hühn, Huei-Ting Yang, Mario Heindl, Roos-Marijn Berbers, Ahmed N. Hegazy, Janina Kionke, Lamis Yehia, Ulrich Sack, Frank Bläser, Anne Rensing-Ehl, Julia Reifenberger, Julia Keith, Simon Travis, Andreas Merkenschlager, Wieland Kiess, Christian Wittekind, Lisa Walker, Stephan Ehl, Stefan Aretz, Michael L. Dustin, Charis Eng, Fiona Powrie, Holm H. Uhlig
Journal: Journal of Allergy and Clinical Immunology (2016)

Patients with heterozygous germline mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) experience autoimmunity and lymphoid hyperplasia.Because regulation of the phosphoinositide 3-kinase (PI3K) pathway is critical for maintaining regulatory T (Treg) cell functions, we investigate Treg cells in patients with heterozygous germline PTEN mutations (PTEN hamartoma tumor syndrome [PHTS]).Patients with PHTS were assessed for immunologic conditions, lymphocyte subsets, forkhead box P3 (FOXP3)+ Treg cell levels, and phenotype. To determine the functional importance of phosphatases that control the PI3K pathway, we assessed Treg cell induction in vitro, mitochondrial depolarization, and recruitment of PTEN to the immunologic synapse.Autoimmunity and peripheral lymphoid hyperplasia were found in 43% of 79 patients with PHTS. Immune dysregulation in patients with PHTS included lymphopenia, CD4+ T-cell reduction, and changes in T- and B-cell subsets. Although total CD4+FOXP3+ Treg cell numbers are reduced, frequencies are maintained in the blood and intestine. Despite pathogenic PTEN mutations, the FOXP3+ T cells are phenotypically normal. We show that the phosphatase PH domain leucine-rich repeat protein phosphatase (PHLPP) downstream of PTEN is highly expressed in normal human Treg cells and provides complementary phosphatase activity. PHLPP is indispensable for the differentiation of induced Treg cells in vitro and Treg cell mitochondrial fitness. PTEN and PHLPP form a phosphatase network that is polarized at the immunologic synapse.Heterozygous loss of function of PTEN in human subjects has a significant effect on T- and B-cell immunity. Assembly of the PTEN-PHLPP phosphatase network allows coordinated phosphatase activities at the site of T-cell receptor activation, which is important for limiting PI3K hyperactivation in Treg cells despite PTEN haploinsufficiency.
ON THE COVER
Authors: Teri A Reynolds
Journal: JAMA (2003)

WAS A WIDE screen that kept a row of yellowing Reader's Digests from sliding off the windowsill.On afternoons when it was too hot to go outside, I read "Laughter, the Best Medicine" and "Humor in Uniform," but what kept me up at night were "All in a Day's Work" and "Drama in Real Life."That adults used stories to make it through a Day's Work, that Real Life was full of Drama, made me yearn for my future.And for a day filled with Work, Life, and Drama, medicine is hard to beat.But whence the stories?Certainly, patients tell us stories; we demand them: What happened?When?How?And then we tell these tales again and again."This is a 55-year-old woman who presents with . . ." is our "Once upon a time . . ."-no less formulaic, and no less infinite in its narrative potential.But our doctor stories, whether we write them down or not, are not the same ones patients bring.They are reaction, analysis, diagnosis, invention, strategy-what we do when faced with a patient's narrative.That days are full of events is inevitable; that they may be filled with stories depends on how we navigate.Stories, and the narrative mode in general, constitute an outlook, a strategic meaning-making.The difference between a string of events and the tale taken home at the end of the day is that we deem this particular series of events worthy of a second thought, a moment of reflection, worthy of the telling-we allow to this day's work, the accumulation of meaning beyond habit.The ability to take in someone's story, to track and contextualize the meaning of a term-what does this patient mean when he says painful, when she says dizzy, when he says weak-is only part of the job.We are readers when we try to understand what has happened to our patients.We are writers when we try to understand what has happened to our selves.In this issue, Jonathan Auten shows us the way a single finding-"A left pupil, fixed and dilated"-yields events of 50 years ago, while Kimberly Mulcahy-Hawes' narrator tells us more than she realizes.Michael McWilliams wonders if this is the end, while Michael Hope struggles with knowing more of the story than his patient does.And, finally, when his patient can't fill in the blanks, Boris Veysman tells himself a story.
ABL001, a Potent, Allosteric Inhibitor of BCR-ABL, Exhibits Safety and Promising Single- Agent Activity in a Phase I Study of Patients with CML with Failure of Prior TKI Therapy
Authors: Oliver G. Ottmann, Giuliana Alimena, Daniel J. DeAngelo, Yeow-Tee Goh, Michael C. Heinrich, Andreas Hochhaus, Timothy P. Hughes, Francois-Xavier Mahon, Michael J. Mauro, Hironobu Minami, Marie Huong Nguyen, Delphine Rea, Juan Luis Steegmann, Arkendu Chatterjee, Varsha Iyer, Noelia Martinez, Gary J. Vanasse, Kim Dong-Wook
Journal: Blood (2015)
Increased Uptake at Sites of Bone Marrow Biopsy Mimicking Bony Metastases on Tc-99m MDP Bone Scintigraphy
Authors: SEOK TAE LIM, MYUNG-HEE SOHN, JAE-YONG KWAK, CHANG-YEOL YIM
Journal: Clinical Nuclear Medicine (2001)

TAE LIM, SEOK M.D.; SOHN, MYUNG-HEE M.D.; KWAK, JAE-YONG M.D.; YIM, CHANG-YEOL M.D. Author Information
Résultats à long terme du traitement des sténoses biliaires bénignes par prothèses biliaires métalliques couvertes
Journal: Endoscopy (2016)

Le traitement endoscopique des sténoses biliaires repose historiquement sur la mise en place de plusieurs prothèses en téflon, nécessitant 3 à 5 CPRE sur une période d’un an. Les prothèses biliaires métalliques ont une force d’expansion radiaire supérieure et un calibre de 10 mm qui laissent espérer une meilleure efficacité.
Abstract P126: Availability of Fast-food Outlets is Associated with Intake of Fast-food
Authors: Charlotte Glümer, Peter Erbs-Maibing, Ulla Toft
Journal: Circulation (2012)

Introduction: Intake of fast-food is associated with an increased risk of health outcomes. The prevalence of obesity and chronic diseases is higher among deprived individuals; studies have shown that the availability of fast-food outlets (FFO) are higher in deprived neighbourhoods than in non-deprived neighbourhoods. Some studies find an association between the availability of FFO and unhealthy diet. Most of studies are performed in US or Australia with different context to Denmark. We hypothesize that a high degree of availability of fast-food is associated with high intake of fast-food in a Danish population. The aim is to examine the association between availability of FFO and frequency of fast-food intake. Methods: Health survey data from the Capital Region of Denmark used in the analyses included a random sample of 95.150 inhabitants aged 16+ from 29 municipalities. Response rate:52,3%. Information’s on fast-food intake and socioeconomic factors is derived from a questionnaire survey (How are you 2010?). Information on FFO is collected through central a register using a validated name recognition method (sensitivity: 82%). Using network analyses in Geographic Information System proximity (Road network distance to the nearest FFO) and density (numbers of FFO within 1 km) of FFO are calculated for each participant. Multilevel regression analyses taking neighbourhood, individual social factors, age and sex into account are performed. Results: 17 % of the population eats fast-food at least once a week, the proportion varies between 10.1% in the rural areas to 27.2 % in the inner-city of Copenhagen. Individuals living in high density areas or with low proximity have a significantly higher risk of eating fast-food once weekly; Compared to individuals living with 0-4 FFO within 1 km the OR’s were 1.4 (95% CI: 1.3-1.6) and 1.8 (95 % CI: 1.7-2.0) for individuals living with 5-9 or ≥ 10 FFO, respectively. After adjustment for individual and contextual factors the OR’s diminished to 1.13, but remained significant. The same picture was seen for proximity, the greater distance to the nearest FFO the lower risk of eating fats-food. Conclusions: This paper shows that availability of fast-food outlets is associated with frequency of eating fast-food weekly. In order to prevent the epidemic of obesity and development of chronic diseases, this may have an impact on future urban planning of fast-food outlets.
Chemotherapy for colorectal carcinoma: observations regarding recent clinical trials using biochemical modulation.
Authors: S Wadler, E L Schwartz
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.10.2676 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7595721 Chemotherapy for colorectal carcinoma: observations regarding recent clinical trials using biochemical modulation. S WadlerxS WadlerSearch for articles by this author , E L SchwartzxE L SchwartzSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.10.2676 PDF "Chemotherapy for colorectal carcinoma: observations regarding recent clinical trials using biochemical modulation.." Journal of Clinical Oncology, 13(10), pp. 2676–2677© 1995 by American Society of Clinical Oncology
Validation of the phase 0 concept.
Authors: J. R. Westin, S. Fu, D. S. Hong, T. Helgason, F. Ouyang, L. S. Angelo, K. S. Culotta, S. N. Westin, R. Kurzrock
Journal: Journal of Clinical Oncology (2011)

TPS143 Background: Over 90% of drugs entering Phase I trials eventually fail, however, it is not currently possible to predict failure prior to undergoing costly and lengthy clinical trials. In response, the FDA proposed an “exploratory IND” (investigational new drug), a novel clinical trial design commonly referred to as “Phase 0”, aimed at accelerating the critical path of drug development. Phase 0 trials expose a small number of patients to a single “microdose” (starting at 1/50th of the no observed adverse effect level, NOAEL, from the most sensitive animal species) of an experimental drug with the goal of validating pre-clinical models to aid in the ‘go/no-go’ decision of drug development. The ultimate goal is to allow Phase 0 effective drugs to enter combination studies earlier, and Phase 0 ineffective drugs to avoid further costly development (Kummar S, Nat Rev Cancer 7:131-139, 2007). We are concerned that potentially effective drugs or classes of drugs may be discarded based on a microdosing concept which has not been effectively validated in human subjects. To our knowledge, the Phase 0 dosing concept has not been evaluated using a known effective agent. Our hypothesis is that a microdose may not be an accurate surrogate for standard doses, and thus, a Phase 0 trial may yield false negative results. We are now conducting a Phase 0 trial evaluating the effects of microdoses of an FDA-approved drug, temsirolimus, on its known pharmacodynamic (PD) targets. The primary endpoint is PD target modulation. Methods: Patients with advanced cancer, preferably with tumor available for biopsy, >5 half lives removed from previous therapy, and being screened for Phase I trials involving temsirolimus will be eligible (n = maximum 15). The exclusion criteria are pregnancy or lactation, <18 years of age, bleeding diathesis, or hypersensitivity to temsirolimus. Temsirolimus will be administered once, with a starting dose level of 0.02 mg (~1/50th NOAEL). PD markers will be assessed in PBMCs before and after dosing. Phase 0 patients who subsequently enroll on a temsirolimus-containing Phase I trial will have the same PD markers assessed to compare drug effect of Phase 0 and Phase I doses. The trial was activated in November 2010, currently has enrolled 4 patients, and is supported in part by 2K12CA088084-11.
Molecular characterization of circulating tumor cells (CTC) and CTC subpopulations in progressive metastatic castration resistant prostate cancer (mCRPC).
Authors: Ryan Dittamore, Jessica Louw, Rachel Krupa, Aseem Anand, Daniel Costin Danila, Zaina Arslan, Natalee Bales, Dena Marrinucci, Howard I. Scher
Journal: Journal of Clinical Oncology (2014)

132 Background: Numerous resistance mechanisms have been postulated in progressive mCRPC. Determining the presence of putative predictive biomarkers in patients requires a real-time tumor assessment because the biology changes under the influence of the specific therapy(ies) that a patient (Pt) has received. We examined CTC and CTC subpopulation incidence and molecular characterization of tumors from Pts with progressive mCRPC to assess if determinants of resistance can be assessed through a CTC test. Methods: 48 samples from 21 unique progressive mCRPC pts treated with androgen receptor targeted (AR tx) therapies, 9 (43%) on Abiraterone plus Prednisone (AA+P) and 12 (57%) on Enzalutamide (E). Samples were collected and shipped to Epic Sciences, where cells were stained and CTC identified by fluorescent scanners and algorithmic analysis. CTCs, defined as classic (CK+ CD45- w/intact DAPI nuclei and distinct), apopotic (CK+, CD45-, non-intact nuclei) and CK- (CK-, CD45-, intact and distinct) were identified. CTCs reported per mL of blood and were examined for AR, PTEN &amp; ERG. CTC data were analyzed in context of PSA, Veridex CTC (reported per 7.5mL of blood), and clinical history. Results: With Epic, all 21 pts had detectable CTCs (mdn 23 cells/ml, range 2 to 249), whereas with Veridex, 14 (67%) pts had &gt; 5 CTC/7.5 ml (mdn 5 cells/7.5 ml, range 0 to &gt;200). 0/7 (0%) with high AR responded to AA+P or E, 8/14 (53%) with low AR had a PSA decline and stable radiographic disease (median follow-up 12 wks). Variations in AR protein expression and localization heterogeneity was seen in all pts to varying degrees. 6/21 (29%) Pts demonstrated CK- CTC/CTC ratio &gt;50% (mdn 9 cells/ml, range 5-38). ERG rearrangement and PTEN loss were correlated. Conclusions: Epic CTC analysis provides higher detection rates, while enabling individual cell analyses for predictive biomarkers of sensitivity to AR directed therapies. Notable was the marked heterogeneity of detection of AR, ERG, and PTEN of individual CTCs. Studies are ongoing to further explore associations with outcomes. [Table: see text]
Obituary Data
Authors: K. Daniel Rose
Journal: JAMA (1974)

<h3>To the Editor.—</h3> While in agreement with the findings that physicians have a significantly higher suicide rate than the general population (228:323, 1974), we seriously question the methodology. The use of obituaries inThe Journalhas been discredited as a reliable research method,<sup>1-3</sup>and it has been found to underreport physician suicides by as much as 50%.<sup>3</sup> Drs. Steppacher and Mausner's claim that women physicians have a suicide rate three times that of a comparable female population needs to be confirmed by other investigators utilizing more reliable and comprehensive sampling methods, such as reviewing all the death certificates of physicians filed in a state for a given time period. Whatever difficulties are posed by any suicide research, particularly on special groups such as physicians, sampling bias is by far the most critical in limiting the generality of results.
Notice of Retraction and Replacement: Kessler RC, et al. Associations of Housing Mobility Interventions for Children in High-Poverty Neighborhoods With Subsequent Mental Disorders During Adolescence.<i>JAMA</i>. 2014;311(9):937-947.
Authors: Ronald C. Kessler, Greg J. Duncan, Lisa A. Gennetian, Lawrence F. Katz, Jeffrey R. Kling, Nancy A. Sampson, Lisa Sanbonmatsu, Alan M. Zaslavsky, Jens Ludwig
Journal: JAMA (2016)

Notice of Retraction and Replacement: Kessler RC, et al. Associations of Housing Mobility Interventions for Children in High-Poverty Neighborhoods With Subsequent Mental Disorders During Adolescence. JAMA. 2014;311(9):937-947.