tbuckley/cabot-search huggingface dataset:
Surgical Management of Varying Patterns of Vertebral-Artery and Subclavian-Artery Insufficiency
Authors: Allan D. Callow
Journal: New England Journal of Medicine (1964)

CEREBROVASCULAR disease ranked third, after heart disease and cancer, as a cause of death in the United States in 1959. Almost 37,000 of these deaths occurred in persons between thirty-eight and sixty-four years of age. In the majority the offending lesion is the atherosclerotic plaque.1 In a small and indeterminate but nevertheless significant number of cases cerebral ischemia may be manifested by signs and symptoms that appear suddenly, last only a few minutes and disappear without residual deficit. These episodic attacks, which recur in the same clinical pattern and with increasing frequency, are episodes of focal cerebral ischemia — manifestations . . .
Abstract 1145: Analysis of circulating tumor cells from castrate resistant prostate cancer patients captured via a microfluidic device using the prostate specific membrane antigen antibody
Authors: Matthew Loftus, Jason Gleghorn, Erica Pratt, Neil Bander, David Nanus, Brian Kirby, Paraskevi Giannakakou
Journal: Cancer Research (2010)

Abstract Prostate cancer (PC) is the most common type of cancer in males and the second leading cause of male cancer deaths in the United States. Circulating tumor cells (CTCs) are commonly found in the blood of patients suffering from mestatic disease and the capture of these cells is important in the study of disease progression. Existing devices use the EpCAM antibody which can capture circulating epithelial cancer cells, but also leads to a large number of leukocyte contamination. We have developed a microfluidic chip functionalized with an antibody to the prostate-specific membrane antigen (PSMA), which captures prostate CTCs with high purity and efficiency. This chip is designed with a staggered obstacle array that maximizes the CTC-wall interactions while minimizing the interactions with the other cells in the blood. PSMA-positive or -negative PC cells were spiked into blood from healthy donors, and we calculated capture rates to be ∼80%. Next, blood samples from patients (n = 20) with castrate resistant prostate cancer (CRPC) were run through the device and CTCs were captured and enumerated. CTCs were found in 90% of samples tested with the number captured averaging 27 ± 4 cells per mL of blood with a capture purity of 62 ± 2%. We plan to use this device to elucidate the molecular basis of CRPC clinical response to taxane treatment, which is the only class of chemotherapy drugs shown to improve survival in this type of PC. Previous data from our laboratory has shown that taxane treatment of PC cells inhibits the ligand-induced androgen receptor (AR) nuclear accumulation and transcriptional activation of androgen response element (ARE) containing genes including the prostate-specific antigen (PSA). These results implicate microtubules (MTs) in AR trafficking and suggest that the clinical activity of taxanes in CRPC may be mediated in part by the drugs’ ability to stabilize MTs and inhibit AR transcriptional activity. We plan to capture CTCs using the PSMA-specific microfluidic device from CRPC patients receiving taxane treatment and analyze them for AR subcellular distribution and correlate clinical response to taxane treatment. Our microfluidic device is a novel, specific, and improved technology to capture prostate CTCs that will allow us to better define the molecular basis of taxane treatment in CRPC patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1145.
Artistic understanding as embodied simulation
Authors: Raymond W. Gibbs
Journal: Behavioral and Brain Sciences (2013)

Bullot & Reber (B&R) correctly include historical perspectives into the scientific study of art appreciation. But artistic understanding always emerges from embodied simulation processes that incorporate the ongoing dynamics of brains, bodies, and world interactions. There may not be separate modes of artistic understanding, but a continuum of processes that provide imaginative simulations of the artworks we see or hear.
Increased MIBG Activity in the Uterine Cervix Due to Menstruation
Authors: Bin Liu, Hua Yang, Ion Codreanu, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2014)

A 21-year-old woman with history of presacral ganglioneuroblastoma underwent I-MIBG scan for restaging. Planar images revealed increased MIBG activity in the upper pelvis, suggestive of disease recurrence. Complementary SPECT/CT images, however, localized the activity to the uterine cervix. Upon further questioning, it has been established that the patient was menstruating. Subsequent follow-up scans proved normal, confirming the benign etiology of these findings. The case shows that radioactive blood accumulation in the uterine cervix can interfere with MIBG scan interpretation in menstruating patients.
AB0524 Comparison of the Clinical Features between Patients with Primary and Secondary Antiphospholipid Syndrome: Results from the Serbian National Cohort Study
Authors: L. Stojanovich, A. Djokovic, D. Marisavljevic, N. Damjanov, N. Stanisavljevic, I. Elezovic
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> Antiphospholipid syndrome (APS) patients suffer from various clinical manifestations with the presence of antiphospholipid antibodies (aPL). APS may manifest itself as a primary disease (PAPS) or as a secondary disease (SAPS), most commonly in the context of Systemic Lupus Erythemathosus (SLE) <h3>Methods</h3> We analyzed 488 patients: 346 PAPS (70.9%) (77.7% female and 22.3% male) average age 44.1±13.0 years and 142 patients with secondary APS (SLE) patients (29.1%) (90.8% female and 9.2% male) average age 47.2±14.8 years. aPL analysis included analysis of aCL (IgG/IgM), β<sub>2</sub>GPI (IgG/IgM) and LA. aPL analysis included analysis of aCL (IgG/IgM), β<sub>2</sub>GPI (IgG/IgM) and LA. In all patients data considering cardiac, vascular, pulmonary, neurological, skin and hematological disorders were collected. <h3>Results</h3> There was 30.8% aCL-IgG, 49.7% aCL-IgM, 31.4% β2GPI IgG, 40.4% β2GPI IgM and 54.0% LA positive PAPS patients. Among SAPS patients 57.9% were aCL-IgG, 61.4% aCL-IgM, 40.7% β2GPI IgG, 45.0% β2GPI IgM and 51.1% LA positive. We observed 56.3% with neurological, 23.0% patients with skin, 27.3% with cardiac, 20.8% with hematological and 15.2% with pulmonary disorders. 54.3% of patients had peripheral vascular thrombosis (arterial, venous or both) in PAPS and 70.4% SAPS patients with skin, 77.3% with neurological, 40.8% with cardiac, 64.8% with hematological and 12.0% with pulmonary disorders. 57.9% of SAPS patients had peripheral vascular thrombosis. Between SAPS and PAPS patients we observed highly statisticaly significant difference considering neurological (p=0.0001), cardiac (p=0.002), skin (p=0.0001) and hematological manifestations (p=0.0001) in favour of patients with SAPS. <h3>Conclusions</h3> Patients with SAPS suffer more often from various clinical features comparing to patients PAPS. Additional autoimmune burden in those patients presented through aPL presence besides actual autoimmune disease pannel, could be an explanation. <h3>References</h3> Stojanovich L, Djokovic A, Marisavljevic D, Ilijevski N, Stanisavljevic N, Mikovic Z, Petkovic M, and Kovcin V. Association between Systemic Non-criteria APS Manifestations and Antibody Type and Level: Results from the Serbian National Cohort Study. Clinical and Experimental Rheumatology, 2013 Sep-Oct;31(5):756-60. Stojanovich L, Markovic O, Marisavljevic D, Elezovic I, Ilijevski N and Stanisavljevic N. Influence of antiphospholipid antibody levels and type on thrombotic manifestations: results from the Serbian National cohort study. Lupus 2011;0: 1–8. <h3>Acknowledgements</h3> This work was supported by research grant number 175041 for 2011-2014, issued by the Ministry of Science of the Republic of Serbia. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2428
Abstract A66: Expression and immunotherapeutic targeting of the SSX family of cancer-testis antigens in prostate cancer
Authors: Heath A. Smith, Robert J. Cronk, Joshua M. Lang, Douglas G. McNeel
Journal: Cancer Research (2011)

Abstract Members of the SSX family of proteins were among the first cancer-testis antigens (CTA) identified. Characterized by tissue-restricted expression to MHC class l-deficient germline cells and frequent ectopic expression in tumors of various histological origin, CTA are highly tumor-specific antigens. SSX proteins comprise a family of ten members with mRNA expression often found in advanced-stage disease and associated with worse patient prognosis. We have previously shown that humoral and cell-mediated immune responses to SSX2 can arise spontaneously in patients with prostate cancer, which combined with the expression of these proteins in MHC class l-negative tissue, makes SSX proteins potentially attractive targets for tumor immunotherapy. In the current study, we evaluated SSX family member expression in prostate cancer cell lines and tumor biopsies to identify therapeutic targets for vaccine therapy in prostate cancer. We found by RT-PCR and qRT-PCR that SSX1, SSX2, and SSX5 were frequently expressed in prostate cancer cell lines and could be induced by treatment with epigenetic modifying agents (EMA) such as 5-aza-2′-deoxycytidine. Furthermore, we observed differential SSX protein expression in paraffin-embedded prostate cancer biopsies on tissue microarray by immunohistochemical staining. Interestingly, SSX expression in patient samples was restricted to metastatic prostate cancer lesions (5/22; 23%), while expression in primary prostate tumors was not observed (0/73). Finally, we determined that it is possible to elicit cross-reactive immune responses to a dominant SSX epitope p103–111 shared by the different SSX family members by immunization of A2/DR1 transgenic mice with SSX peptides or a plasmid DNA vaccine encoding SSX2. Overall, these results suggest that multiple SSX family members are expressed in prostate cancer and can be simultaneously targeted using immunotherapeutic vaccines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr A66.
Carotenoid and vitamin E levels in children with cancer.
Authors: O. Kucuk, N. Tacyildiz, K. Kose, H. Dincaslan, G. Yavuz, E. Unal, D. Ozyoruk, M. Karatepe, E. Suskan, K. Sahin
Journal: Journal of Clinical Oncology (2010)

e20004 Background: Carotenoids and vitamin E are potent antioxidants and potential cancer preventive compounds. There are no reports of beta-carotene, vitamin A, lycopene, lutein and vitamin E together in children with cancer. Methods: Measurements of the serum carotenoid levels were performed by HPLC in 49 children with cancer—ALL (n = 10), non-Hodgkin's lymphoma (NHL, n = 6), neuroblastoma (NBL, n = 11), retinoblastoma (RBL, n = 22)—and 21 healthy children (ages 9 months—14 years, median: 7 years) and results were evaluated by SPSS. Results: Carotenoid and vitamin E levels of children with cancer were significantly lower than healthy children. However, differences in serum carotenoid levels depending on the disease status (during diagnosis, remission, or progression) were observed. Although we had a small number of patients, we observed higher levels during remission, lower levels during progression when compared to levels at diagnosis. Cutoff levels of carotenoids for having a childhood cancer were as follows: Beta-carotene: 49 μ g/ml, lycopene: 4.73 μ g/dl, lutein: 0.09mg/L and Vit E: 5.38μ g/ml. Conclusions: Although we had a small number of patients to compare carotenoid and vitamin E levels during diagnosis, remission, or progression, there was a positive correlation with remission status but inverse correlation with progression status. Our data suggest a cutoff level of carotenoids (except for Vit A) and vitamin E for risk of having childhood cancer. Studies assessing supplementation of these antioxidants in pediatric cancer patients should be considered. Carotenoid and vitamin E levels in children with cancer and healthy controls Carotenoids Group (n) Range Median p value Beta-carotene μ g/ml Control (21) 37.422–846.515 125.797 0.0001 Patients (34) 10.071–65.031 23.8415 Vit A μ g/ml Control (21) 0.904–2.284 1.337 0.123 Patients (49) 0.321–4.401 1.073 Vit E μ g/ml Control (21) 2.475–24.351 7.864 0.0001 Patients (43) 0.455–26.851 3.092 Lycopene μ g/dl Control (21) 2.433–109.233 33.233 0.0001 Patients (40) 0.008–0.220 0.042 Lutein mg /L Control (21) 0.04–0.650 0.186 0.0001 Patients (49) 0.008–0.220 0.042 No significant financial relationships to disclose.
P77 Carcinoma In-situ At The Bronchial Resection Margin - A Case For Routine Surveillance With Autofluorescence Bronchoscopy
Authors: R. Thakrar, J. Brown, H. Apperley, M. Falzon, D. Lawrence, P. George, N. Navani, S. Janes
Journal: Thorax (2014)

<h3>Introduction</h3> Lung cancer is the leading cause of cancer mortality worldwide, with squamous cell carcinomas commonly arising in the central airways and accounting for nearly 30% of cases. Progression from normal bronchial epithelium to carcinoma in-situ (CIS) has been well described, and is found at the resection margin after lobectomy in up to 2.5% of cases; however, its fate has not been defined. <h3>Method</h3> Cases referred to the autofluoresence bronchoscopy (AFB) surveillance programme at this institution were analysed retrospectively from 1999–2012, for all those shown to have CIS at the resection margin following surgery for TxN0M0 squamous cell carcinoma. Patients underwent longitudinal assessment of the tracheobronchial tree to (a) confirm CIS at the resection margin and track its fate over time (b) characterise development of other preinvasive lesions. <h3>Results</h3> Twenty-two cases were identified with a median interval of 6 months (range 3–9) from surgical resection to first AFB. Thirteen patients (59%) were confirmed to have CIS on biopsy at the bronchial resection margin during the first AFB. Eleven (85%) of these progressed to invasion over a median interval of 37 months (range 4–85). A subgroup of these (5 patients) developed 8 invasive cancers at sites distant to the anastomotic site and 9 patients had &gt;1 CIS lesion at a distant site. Two patients (9%) found to have CIS after initial post-resection AFB, persisted after follow-up of 36–45months. Although no progression has been seen, both have developed CIS at distant sites to the resection margin. Nine patients (41%) were found to have no evidence of CIS at the resection margin and during a median surveillance period of 37 months (range 19–126), all were found to have normal bronchial epithelium. One patient in this group developed a second primary lung cancer that was surgically resected. <h3>Conclusion</h3> CIS at the bronchial resection margin is a strong indicator of its fate to progression to invasive carcinoma. Its persistence sets precedent for the development of multiple, consecutive CIS lesions and invasive squamous cell carcinomas, and highlights the importance of routine AFB surveillance following surgery in these cases.
AB0160 The urinary excretions of albumin as a marker of cardiovascular risk in patients with rheumatoid arthritis
Authors: A. Rebrov, M. Tyapkina, E. Voloshinova
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Even the earliest subclinical renal dysfunction is an important independent risk factor for cardiovascular disease [1]. It is cardiovascular complications associated with atherosclerotic vascular disease that are the leading causes of premature mortality in rheumatoid arthritis (RA) [2]. <h3>Objectives</h3> To determine the urinary excretions of albumin in patients with RA, to identify the relationship of this indicator with risk factors for cardiovascular disease. <h3>Methods</h3> The study included 73 patients with RA at the age 18 to 60 years, who were treated at the rheumatology department of the regional hospital. Exclusion criteria were an associated kidney diseases, hypertension stage III, any kind of secondary nephropathy and pregnancy. We investigated the urinary excretions of albumin (Al) by immunoturbidimetric method in a morning urine sample. The urinary albumin excretion was considered normal for the index of Al/urine creatinine less than 17 mg/g in men and 25 mg/g in women. The arterial stiffness was detected using a Tensioclinic arteriograph (Tensiomed, Hungary). The pulse wave velocity in the aortaand augmentation index were measured. The ultrasound measuring of the carotid intima-media thickness was performed to study subclinical atherosclerosis. <h3>Results</h3> The urinary excretion of Al in the patients with RA was significantly higher than in control subjects matched for age, body mass index, blood pressure (50.27 [23.2, 100.82] mg/g and 23.43 [17.92, 30.42] mg/g, respectively, p&lt;0.001). Increased urinary albumin excretion was found in 52 (71%) patients. The correlation was found of the urinary excretion of Al with age (r = 0.266; p = 0.023), the multiplicity of nonsteroid anti-inflammatory drugs (NSAIDs) in the month prior to the study (r = 0.271; p = 0.027), glomerular filtration rate, which was calculated by using the Modification of Diet in Renal Disease (r = -0.282; p = 0.016), low density lipoprotein (r= 0.367; p = 0.005), atherogenic index (r = 0.415; p = 0.001), pulse wave velocity in the aorta (r = 0.258; p = 0.039), augmentation index in the aorta and brachial artery (r = 0.346; p = 0.005), the carotid intima-media thickness (r = 0.270; p = 0.021). <h3>Conclusions</h3> The urinary excretion of Al in the patients with RA is significantly higher than in the control group. Increased urinary albumin excretion correlates with risk factors for cardiovascular disease (hypertension, dyslipidemia, the arterial stiffness) and with the features of the development of the RA (multiple NSAIDs). <h3>References</h3> Astor B.C., Hallan S.I.Miller E.R. et al. Glomerular filtration rate, albuminuria, and risk of cardiovascular and all-cause mortality in the US population. American Journal of Epidemiology2008;167:1226-1233 CaplanM. J. Cardiovasculardiseaseinrheumatoidarthritis. Curr. Opin. Rheumatol., 2006;18:289-97. <h3>Disclosure of Interest</h3> None Declared
Abstract 4592: ER-beta inhibits cell proliferation in normal mammary epithelial cells
Authors: Zhongzong Pan, Yili Zhong, Xiaozheng Song
Journal: Cancer Research (2010)

Abstract ER-beta is the second subtype of estrogen receptor and its role in mammary epithelial cell proliferation remains obscure. Studies using human breast cancer cell lines suggest that ER-beta may function as a tumor suppressor to inhibit cell proliferation. In the in vivo mouse studies, however, activation of ER-beta was shown to promote cell proliferation of normal mammary epithelial cells. It is not clear whether the difference is caused by the different experimental models, such as in vitro versus in vivo or breast cells versus normal cells. In our studies, we evaluated the effect of ER-beta on cell proliferation using immortalized normal mammary epithelial cell lines. We found that cell proliferation was significantly inhibited by ER-beta. FACS analysis on cell cycle showed that more cells were in the G2/M phase, suggesting that ER-beta may induce G2 arrest. The inhibitory function of ER-beta is independent of estrogen binding. In summary, our data support that ER-beta is a negative regulator of mammary epithelial cell proliferation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4592.
Chemoprevention Studies: Controlling Effects of Initial Nutrient Levels
Authors: M. LIPKIN, H. NEWMARK
Journal: JNCI Journal of the National Cancer Institute (1993)

Table 2.Estimated relative risks (RRs) and 95% confidence intervals (CIs) of low-grade and high-grade CIN associated with HPV DNA detection, in three age groups Age, yt 16-28 HPV -HPV + 29-39 HPV -HPV + 3«40 HPV -HPV + No. of control subjects (%) 106 47 (30.7) 131 17 (11.5)136 16 (105) Low-grade No. of case subjects (%) 13 217 (94.4) 28 73 (72.3) 43 48 (52.8)CIN* 20.0 (10.0-39.0)It 9.5 (4.9-18.0)No. of case subjects (%) 1 16 (94.1)
P464 RESISTANCE TO THROMBOMODULIN IS ASSOCIATED WITH DE NOVO PORTAL VEIN THROMBOSIS AND COULD BE A MODIFIABLE FACTOR TO IMPROVE PROGNOSIS IN PATIENTS WITH CIRRHOSIS
Authors: V. La Mura, A. Tripodi, F. Cavallaro, V. Chantarangkul, M. Colombo, M. Primignani
Journal: Journal of Hepatology (2014)
EUS features in patients with AIP based on the Rosement classification
Authors: Ga Ryo, Kubota Kensuke, Kato Shingo, Watanabe Seitro, Kaneko Takashi, Shimamura Takeshi, Kobayashi Noritoshi, Sugimori Kazuya, Maeda Shin, Nakajima Atsushi
Journal: Endoscopy (2011)

Background: Rosemont classification (RC) for chronic pancreatitis (CP) is promising in the diagnosis of autoimmune pancreatitis (AIP), however, endoscopic ultrasound (EUS) features of AIP based on the RC has not been evaluated. Aim: To study the EUS findings based on RC in the diagnosis for AIP. Methods: 38 patients of AIP who underwent EUS were identified from our data base between April 2004 and July 2010. EUS findings taken at the pancreatic body in patient with AIP were studied. We reviewed the following features of EUS according to RC, such as hyperechoic foci with/without shadowing, lobularity with/without honeycombing, cysts, strands, main pancreatic duct (MPD) calculi, irregular main pancreatic duct contour, dilated side branches and hyperechoic MPD margin. We also examined histopathological findings obtained by endoscopic-ultrasound-guided fine needle aspiration biopsy of each stratification of AIP (consistent with CP, suggestive of CP and indeterminate for CP). Finally, we evaluated the rate of spontaneous remission and unfavorable events (relapse) taken the EUS features into consideration. Results: As for the diagnostic stratum based on RC, there were 17 patients with consistent with CP, 13 patients with suggestive of CP and 8 patients with indeterminate for CP. EUS findings; hyperechoic foci with shadowing 57.9% (22/38), lobularity with honeycombing 71.1% (27/38), lobularity without honeycombing 31.6% (12/38), hyperechoic foci without shadowing 44.7% (17/38), cysts 7.9% (3/38), stranding 34.2% (13/38), MPD calculi 0%, irregularity of MPD contour 23.7 (9/38), dilated side branches 44.7% (17/38), MPD dilatation 23.7% (9/38) and hyperechoic duct margin 60.5% (23/38). The most common findings were lobularity with honeycombing as parenchymal feature and hyperechoic duct margin as ductal feature. Regarding the histopathologic findings, acinar cells were preserved in patients with indeterminate for CP or suggestive of CP, besides, the acinar cells disappeared and replaced by massive fibrosis in patients with consistent with CP. Unfavorable event was significantly more recognized in patients with consistent with CP than with suggestive of CP or with indeterminant for CP based on RC (p=0.0258). Conclusions: Our results suggest that RC is potentially useful in the diagnosis and predictable for unfavorable events of AIP.