tbuckley/cabot-search huggingface dataset:
P410The impact of ischaemia reperfusion on aging rat heart physiological and molecular parameters
Authors: C R Revnic, C Ginghina, C Pena, F Revnic, B Paltineanu
Journal: Cardiovascular Research (2014)

Introduction: Heart muscle is largely dependent on uninterrupted blood flow, which guarantees delivery of substrates and washout of harmful products of metabolism. During aging, a lot of degenerative changes occur at the levels of all organs and heart is not an exception. Ischemia is a frequent phenomenon associated with aging and this means the decrease or cessation of myocardial blood flow, which leads to changes in myocardial metabolism The concept of "self regulation" is based on the axiom that the heart is a regulatory system, integrating many internal and external functional units. The aim of study: Was to point out how physiological parameters of cardiac contractility such as: H.R.(heart rate),C.F.(coronary flow),and LVPD(left ventricle developed pressure) are affected, by 45 minutes ischemia followed by 60 minutes reperfusion as well as to assess left ventricle for apoptosis. Material and methods: Our study has been done on 12 female Wistar rats aged 6 and respectively 32 months old. The animals have been anesthetized i.p. with Na Phenobarbital (60mg/kg body weight) and Heparin(300 U i.p.). After the abolishment of reflexes, hearts were excised and placed in ice cold perfusion medium and quickly mounted in Langendorff retrograde perfusion system. A 45 minutes ischemia by stopping perfusion fluid has been followed by 60 minutes reperfusion. Has been investigated the impact of oxidative stress generated by ischemia-reperfusion upon physiological parameters of rat heat of different ages respectively: C.F., H.R. and LVPD. Molecular modifications induced by the oxidative stress have been followed by pointing out DNA fragments detected by DNA laddering kit Cat.Nr.TA 4630 purchased from R&D Systems England. Results: Our data have pointed out a constant decrease in cardiac frequency during experiment in both animal groups. In old rats H.R. presented net elevated values versus controls. LVPD presented lower values in old rats during experiment while C.F. has recorded higher values versus controls. Myocyte apoptosis from left ventricle has been pointed out on gel electrophoresis by DNA internucleosomal fragmentation. Conclusions: Oxidative stress of ischemia-reperfusion generated modifications of H.R. in old rats and of C.F. which can be explained by adaptation of old heart rat to the new experimental conditions which at the molecular level have been reflected by appearance of apoptosis phenomenon in ventricular myocytes.
If at first you don't succeed with IT, keep trying, conference is told
Authors: N. Hawkes
Journal: BMJ (2013)

The NHS will need to transform the way it uses information technology if it is to improve quality and reduce costs, delegates at the King’s Fund annual conference heard on 13 November. 

The costly failure of Connecting for Health, which promised much but delivered little, should not discourage a fresh attempt: others have failed equally catastrophically but gone on to deliver successful systems.

Bill Wright, executive medical director of Colorado Permanente (a branch of California-based Kaiser Permanente) which provides healthcare to half a million people in the Rocky Mountain state, said that the success of its electronic health records system had followed a “painful” failure to co-develop such a system with IBM. 

And Brent James, chief quality officer of Intermountain Healthcare, which runs 22 hospitals in Utah, said that his organisation had failed twice before achieving success, failures that had cost two vice presidents their jobs—“good men,” he added.

Wright agreed with …
AB0380 Treat-to-target in systemic lupus erythematosus: report from the t2t/sle working party
Authors: R. F. Van Vollenhoven, M. Mosca, G. Bertsias, A. Kuhn, K. Lerström, J. Smolen, D. Isenberg, M. Schneider
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The principle of “treating-to-target” has been applied successfully to many diseases outside rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic targets and pursuing these systematically has led to improved care for patients with these diseases and useful guidance for health care providers and administrators. Thus, an initiative to develop treat-to-target guidance was believed to be of benefit in SLE as well. <h3>Objectives</h3> To derive Treat-to-target guidance for SLE. <h3>Methods</h3> Thirty-four specialists in rheumatology, nephrology, dermatology and/or clinical immunology and a patient representative contributed to this initiative. The majority convened on three occasions. During the first meeting, the broad outlines of the project were discussed and agreed upon. During the second meeting, 12 topics of critical importance for this endeavor were identified. Subsequently, a systematic literature review was performed on those topics. The results of this search were condensed and reformulated as ‘bullet points’ or, alternatively, as items for a research agenda. At the third meeting, these bullet points were discussed, modified, and voted upon. A set of overarching principles was also developed and agreed upon. These results were further discussed during two telephone conferences. In the spring of 2013 the final bullet points will be circulated and degrees of agreement will be evaluated. <h3>Results</h3> The twelve systematic literature searches and their summaries led to ten bullet points which were extensively discussed, modified and voted upon. Broad agreement (&gt;90% in favor) was reached for all but one bullet point. The bullet points include specified targets of remission for lupus nephritis and for at least some patients with non-renal lupus; the importance of disease control, reduction of flares, and prevention of disease-related damage; the need to use validated instrument for defining the target and to ensure assessment of the target at follow up; special consideration of health-related quality-of-life as a target distinct from inflammatory control; appropriate use of the therapeutic categories used for SLE including glucocorticoids, antimalarials, and immunomodulatory/immunosuppressive medications; and consideration of comorbidities. Four overarching principles were agreed upon, and an extensive research agenda was also identified. <h3>Conclusions</h3> The groundwork for a treat-to-target-in-SLE (T2T/SLE) document was prepared including recommendations agreed upon by a large panel of multi-specialty experts and patient representative. It is anticipated that “treating-to-target” can and will be applicable to the care of patients with SLE. <h3>Disclosure of Interest</h3> None Declared
Case 4-2009
Authors: Patrick Duff, William H. Barth, Miriam D. Post
Journal: New England Journal of Medicine (2009)

A 39-year-old woman in the first trimester of her first pregnancy was seen in the obstetrics and gynecology clinic of this hospital at 14 weeks of gestation because of persistent fevers. She had recently traveled to Africa to adopt a child. In the interval between returning home and becoming ill, she became pregnant. On examination, there was a maculopapular rash over the trunk, arms, and legs, as well as a slightly enlarged liver. Sequential ultrasound examinations showed an apparently normal fetus.
Can we develop self-expandable metallic stents without consideration of mechanical properties?
Authors: Hiroyuki Isayama, Yousuke Nakai, Hirofumi Kogure, Tsuyoshi Hamada, Natsuyo Yamamoto, Kazuhiko Koike
Journal: Endoscopy (2014)

We read with great interest the paper by Hirdes et al., in which the authors evaluated, for the first time, the mechanical properties (radial and axial force) of esophageal stents [1]. We would like to make two comments on this paper.
Erythrocyte Hexokinase Isoenzyme Patterns in Hereditary Hemoglobinopathies
Authors: John I. Malone, Albert I. Winegrad, Frank A. Oski, Edward W. Holmes
Journal: New England Journal of Medicine (1968)

Three forms of hexokinase activity can be demonstrated in hemolysates of normal human erythrocytes by starch-gel electrophoresis. The similarity of these isoenzymes to Types I, II and III hexokinases found in other mammalian species has been confirmed by isolation of Types I and II erythrocyte hexokinases by chromatography on DEAE-cellulose. Type II is the predominant isoenzyme in the erythrocytes of newborn infants, but it is present in low or undetectable levels in those of normal adults. The presence of significant Type II hexokinase activity does not appear to be a function of erythrocyte age; increased activity has been demonstrated in the erythrocytes of adults who are homozygous for hemoglobins S, C or F or who are heterozygous for hemoglobins S or F. These observations suggest a previously unsuspected relation between the regulation of hemoglobin synthesis and the enzymatic composition of the erythrocyte.
Successful treatment of esophageal fistulas with endoscopic injection of alpha-cyanoacrylate monomer
Authors: Toshiyasu Ojima, Mikihito Nakamori, Masaki Nakamura, Masahiro Katsuda, Takeshi Iida, Keiji Hayata, Katsunari Takifuji, Makoto Iwahashi, Shuichi Matsumura, Tomoya Kato, Junya Kitadani, Hiroki Yamaue
Journal: Endoscopy (2014)

The application of glue is an established treatment for fistulas [1] [2]. We consider that the alpha-cyanoacrylate monomer (α-CA) is ideal for glue embolization of intractable fistulas in the gastrointestinal tract because the α-CA glue spreads faster, so creating a bond more rapidly than the other polymer glues, such as n-butyl cyanoacrylate polymer and 2-octyl cyanoacrylate polymer [3]. However, there have been few reports of successful fistula closure using α-CA glue [4].
SAT0044 Five-Year Favourable Outcome of Patients with Early Rheumatoid Arthritis in the 2000S: Data from the Espoir Cohort
Authors: B. Combe, N. Rincheval, J. Benessiano, F. Berenbaum, A. Cantagrel, J.-P. Daures, M. Dougados, P. Fardellone, B. Fautrel, R.-M. Flipo, P. Goupille, F. Guillemin, X. Le Loet, I. Logeart, X. Mariette, O. Meyer, P. Ravaud, A. Saraux, T. Schaeverbeke, J. Sibilia
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To report the 5-year outcome of a large prospective cohort of patients with very early rheumatoid arthritis (RA), and to identify predictive factors of outcome. <h3>Methods</h3> Patients were recruited if they had early arthritis of less than 6 months' duration, a high probability of developing RA, and had never been prescribed DMARDs or steroids. Patients were followed every 6 months during the first 2 years, then every year. Logistic regression analysis was used to determine predictive factors of outcome. <h3>Results</h3> 813 patients were included from December 2012 to april 2005: age was 48.1 ± 12.6 years, delay before referral 103.1 ± 52.4 days, DAS28 5.1 ± 1.3, HAQ 1.0 ± 0.7; 44.2 and 38.8% had IgM Rheumatoid Factor or anti-CCP2 antibodies; 22% had hands or feet erosions; 78.5% fulfilled the ACR/EULAR criteria for RA at baseline and 93.8% during follow-up. 573 patients were evaluated at 5 years. The outcome was mild for most patients: disease activity (median DAS28 2.5) and HAQ (median 0.3) were well controlled over time; 47.6% achieved DAS28 remission and 64.6% low disease activity in the first 2 years. Radiographic progression was low (2.9 Sharp unit / year). Only a few patients required joint surgery, but some developed new co-morbidities (eg, hyperlipemia, cardiovascular diseases). During the 5 years, 82.7% of patients had received at least one DMARD (methotrexate: 65.9%) usually as monotherapy, 18.3% a biological DMARD, and about 60% prednisone at least once (mean dosage 8.8 ± 7.7 mg/day). Anti-CCP2 antibodies was the best predictor of 5-year remaining in the cohort, prescription of synthetic or biologic DMARDs, and radiographic progression. <h3>Conclusions</h3> The generally good 5-year outcome of this cohort could be related to early referral, early effective treatment and close monitoring which are key processes in the management of early RA in daily practice. <h3>Disclosure of Interest</h3> B. Combe: None Declared, N. Rincheval: None Declared, J. Benessiano: None Declared, F. Berenbaum: None Declared, A. Cantagrel: None Declared, J.-P. Daures: None Declared, M. Dougados: None Declared, P. Fardellone: None Declared, B. Fautrel: None Declared, R.-M. Flipo: None Declared, P. Goupille: None Declared, F. Guillemin: None Declared, X. Le Loet: None Declared, I. Logeart Employee of: Pfizer, X. Mariette: None Declared, O. Meyer: None Declared, P. Ravaud: None Declared, A. Saraux: None Declared, T. Schaeverbeke: None Declared, J. Sibilia: None Declared
AB0547 Rapid and novel immune assay platform of serum tocilizumab concentration applied by quartz-crystal microbalance (QCM) biosensor system
Authors: S. Ota, T. Ozeki, H. Hoshino, K. Terao
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Tocilizumab(TCZ) is a humanized anti-human interleukin-6(IL-6) receptor monoclonal antibody. To establish the optimal dosage strategy prediction based on the PK/Biomarker relationship is one of the important tool during the drug development. The optimal dosage of tocilizumab (8mg/kg/4wk) was originally simulated using serum trough TCZ concentration and CRP relationship. Most of the monoclonal antibody drug development, serum concentration levels were determined conventional enzyme-linked immunosolvent assay (ELISA). Although ELISA were time consuming and labour intensive, we have evaluated the alternative technologies using quartz-crystal microbalance (QCM) biosensor system which is the novel and rapid quantitative method to monitor the serum TCZ concentration. <h3>Methods</h3> For rapid and direct quantification of Tocilizumab in human plasma, we used QCM biosensor system that can be monitored a real-time binding amount of analyte without any troublesome steps such as enzyme amplification and washing plates. Concentrations of Tocilizumab were directly determined by analyzing binding kinetics of Tocilizumab to IL-6R-precoated sensor chip. In the validation step of QCM, reproducibility, repeatability and calibration range was demonstrated. Finally the serum tocilizumab concentration in patients with active rheumatoid arthritis under TCZ therapy, was compared between QCM and ELISA. <h3>Results</h3> The lower quantification limit with the quantification range is between 3.25 to 100 ug/mL, and an intra-day standard deviation (SD) of 5.26-12.5% and an inter-day SD of 8.38% at 10 ug/mL in serum. The lower quantification level is 3 ug/mL which is three times lower sensitivity than conventional ELISA (LLOQ=1ug/mL). Correlation between ELISA and QCM was demonstrated that the correlation coefficient showed r2=0.98 (n=15), and the deviation between two methods were within ±2 μg/mL within quantification range of this QCM. <h3>Conclusions</h3> When the requirements of cost and running time are beyond the scope of conventional ELISA, this QCM is one of the solution to save these two points and is able to keep the equivalent accuracy and repeatability. From this study, we need to try to find the well-optimaized condition which focused on the equivalent level of lower quantification level. <h3>Disclosure of Interest</h3> S. Ota: None Declared, T. Ozeki Employee of: ULVAC Inc, H. Hoshino Employee of: ULVAC Inc, K. Terao Employee of: Chugai Pharmaceutical Co.,Ltd
Case 13-2003
Authors: G. Naheed Usmani, Sjirk J. Westra, Souhad Younes
Journal: New England Journal of Medicine (2003)

Presentation of CaseA 14-month-old boy was admitted to the hospital because of hepatomegaly, left-sided ptosis, and a bony lump on the forehead.The patient had been constipated for several months, passing one hard stool every two or three days with pain. Three months before admission, fevers began; his temperature rose as high as 39.4°C for two to three days. About two months before admission, intermittent sweats occurred, as did fevers, with temperatures that seldom exceeded 37.8°C. About two months before admission, the patient was noted to have a perianal rash. A dermatologist prescribed a series of topical treatments that . . .
Experts Sharply Divided on Prostate Cancer Screening
Authors: L. Schwab
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Experts Sharply Divided on Prostate Cancer Screening Get access Linda Schwab Linda Schwab Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 8, 17 April 1991, Pages 535–536, https://doi.org/10.1093/jnci/83.8.535 Published: 17 April 1991
PREDICTORS OF DEFINITE OR PROBABLE STENT THROMBOSIS OCCURRING AFTER 1 YEAR IN A LARGE COHORT OF PATIENTS TREATED WITH OLD AND NEW GENERATION DRUG-ELUTING STENTS IN DAILY CLINICAL PRACTICE
Authors: Ricardo Costa, Amanda Sousa, Jose de Ribamar Costa, Adriana Moreira, Galo Maldonado, Manuel Cano, Ricardo Pavanello, Cantídio Campos Neto, Lucas Damiani, Jose Eduardo Morais Rego Sousa
Journal: Journal of the American College of Cardiology (2016)
POOR HEART RATE RESERVE PREDICTS NEW ONSET ATRIAL FIBRILLATION IN MIDDLE AGED ADULTS
Authors: Avi Sabbag, Anat Berkovitch, Yechezkel Sidi, Shaye Kivity, Roy Binart, Shlomo Segev, Michael Glikson, Ilan Goldenberg, Elad Maor
Journal: Journal of the American College of Cardiology (2016)
Charcoal-induced pseudomelanosis ilei
Authors: S. Kim, J. Koo, J. Hynun, S. Jung, R. Choung, H. Yim, S. Lee, J. Choi
Journal: Endoscopy (2011)

A 32-year-old woman was referred to our outpatient department because of anal bleeding. She had been diagnosed with ulcerative proctitis about 1 year previously and had experienced intermittent anal bleeding during treatment at a local clinic. She had no significant medication history and in particular had not used laxatives or oral iron. The initial colonoscopy revealed numerous variable-sized areas of black pigmentation in the mucosa of the terminal ileum ([Fig. 1 a]); however, the pigment was not detected in the colorectum.
DOSE-DEPENDENT EFFECTS OF INTRACORONARY CARDIAC STEM CELLS IN RATS WITH ACUTE MYOCARDIAL INFARCTION
Authors: Xian-Liang Tang, Gregg Rokosh, Santosh K. Sanganalmath, Gregg Shirk, Heather Stowers, Gregory N. Hunt, Buddhadeb Dawn, Roberto Bolli
Journal: Journal of the American College of Cardiology (2015)
A pseudosarcomatous lesion resembling a malignant tumor of the esophagocardiac junction, diagnosed by a total biopsy with endoscopic surgery
Authors: K. Ando, M. Fujiya, T. Ito, R. Sugiyama, T. Nata, Y. Nomura, N. Ueno, S. Kashima, C. Ishikawa, Y. Inaba, K. Moriichi, K. Okamoto, K. Ikuta, H. Tanabe, Y. Tokusashi, N. Miyokawa, J. Watari, Y. Mizukami, Y. Kohgo
Journal: Endoscopy (2012)

A pseudosarcomatous lesion is a benign lesion resembling sarcoma either clinically or histologically, which often leads to unnecessary or excessive treatments, including esophagectomy [1] [2] [3]. This report presents a case of a pseudosarcomatous lesion which was correctly diagnosed by a total biopsy with endoscopic submucosal dissection (ESD) [4].
Infectious Pulmonary Disease in Patients Receiving Immunosuppressive Therapy for Organ Transplantation
Authors: Rolla B. Hill, David T. Rowlands, David Rifkind
Journal: New England Journal of Medicine (1964)

WHOLE-organ homotransplantation is a modality of therapy that has only recently been submitted to clinical investigation in man,1 and reports on the natural history of patients so treated are therefore fragmentary. The clinical course of such patients obviously is profoundly influenced by the chemotherapy that they receive, usually including corticosteroids and immunosuppressive antimetabolites. These compounds have a wide range of effects on the host metabolic reactions, and they so alter immunologic responsiveness that changes in the spectrum of infectious disease may reasonably be expected.Up to February, 1964, 61 patients had received homotransplants or heterotransplants at this center; of these . . .
Fibrinogen as a Risk Factor for Stroke and Myocardial Infarction
Authors: Lars Wilhelmsen, Kurt Svärdsudd, Kristoffer Korsan-Bengtsen, Bo Larsson, Lennart Welin, Gösta Tibblin
Journal: New England Journal of Medicine (1984)

To study the possible risk factors for cardiovascular disease, we collected data on plasma levels of coagulation factors, blood pressure, serum cholesterol, and smoking in a random sample of 792 men 54 years of age. During 13.5 years of follow-up, myocardial infarction occurred in 92 men, stroke in 37, and death from causes other than myocardial infarction or stroke in 60. The blood pressure, degree of smoking, serum cholesterol, and fibrinogen level measured at the base-line examination proved to be significant risk factors for infarction by univariate analyses during follow-up, and blood pressure and fibrinogen were risk factors for stroke. Fibrinogen and smoking were strongly related to each other. The relation between fibrinogen and infarction, and between fibrinogen and stroke, became weaker when blood pressure, serum cholesterol, and smoking habits were taken into account, but was still significant for stroke. Although causality cannot be inferred from these data, it is possible that the fibrinogen level plays an important part in the development of stroke and myocardial infarction. (N Engl J Med 1984; 311:501–5.)
Biliary endoscopic retrograde cholangiopancreatography
Authors: M Bourke
Journal: Endoscopy (2011)

Pancreatic cancer is common and highly lethal and has a median age at diagnosis of 70 years. It is the fifth leading cause of cancer-related death in the Western World, second among gastrointestinal malignancies, surpassed only by colorectal cancer. Obstructive jaundice is a common presentation. Although the prognosis is generally dismal, surgery remains the only option for cure in those with a potentially resectable tumor. It is also an effective and durable palliative option in patients with good functional status and localized disease. Ultimately less than 20 % of patients with malignant distal biliary obstruction are candidates for surgical cure.
The Delaney Clause: Too Much of A Good Thing?
Authors: J. Corliss
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article The Delaney Clause: Too Much of A Good Thing? Get access Julie Corliss Julie Corliss Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 8, 21 April 1993, Pages 600–603, https://doi.org/10.1093/jnci/85.8.600 Published: 21 April 1993