tbuckley/cabot-search huggingface dataset:
US obesity rates are leveling out, but long term effects raise concern
Authors: M. McCarthy
Journal: BMJ (2013)

The prevalence of obesity in US adults seems to be leveling out after three decades of big rises, a new report concludes. From 2012 to 2013 the prevalence remained level in all states except Arkansas, which saw its obesity rate climb from 30.9% in 2011 to 34.5% in 2013.

But another study estimates that deaths related to obesity might be much higher than previously thought.

The first report, F as in Fat , is the latest in an annual series produced by the Robert Wood Johnson Foundation and the Trust for America’s Health as a means to track the US obesity epidemic.1 It shows that adult obesity rates in the US have more than doubled over the past 30 years, rising …
AB1175-HPR The Effects of Clinical Pilates Exercises on Kinesophobia in Women with Osteoporosis
Authors: S. Oksuz, E. Ünal, P. Dizmek, D. Aydin Ozcan
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Osteoporosis (OP), is the most frequent metabolic bone disease and most common public health problem worldwide. Chronic pain is the most common complication in OP patients and causes fear-avoidance beliefs and kinesophobia (1-4). Exercise therapies and active life style were advised for management of OP (5). In literature, clinical pilates exercises were used in pain management and for improving postural/mechanical problems. <h3>Objectives</h3> The aim the study is to investigate the effects of clinical pilates exercise on kinesophobia in women with OP. <h3>Methods</h3> 47 female OP patients were included in this study, they were randomly divided into 2 groups, as there would be 23 patients in control group, 24 patients in exercise group. Patients in exercise group joined exercise program regularly that was held 3 times a week, 1 hour a day, during 6 weeks with physiotherapist. Patients in control group continued their normal daily living without doing exercise during 6 weeks. Visual Analogue Scale (VAS) was used for pain, Pain disability Index (PDI) was used for pain related disability and Tampa Kinesophobia Scale was used. <h3>Results</h3> 40 patients (control group n=20, exercise group n=20) completed study who were assessed initially and at the end of 6 weeks. According to the measurements that were taken at the end of the study, exercise group patients9 pain, disability and fear of movement level decreased when compared to the control group9s (p&lt;0,05). <h3>Conclusions</h3> This study showed that providing positive effects on kinesophobia seen on the patients9 diagnosed with OP, clinical pilates exercise training can be recommended to the patient, as a safe exercise model. <h3>References</h3> Bab, I.A., Yirmiya, R. (2010). Depression and bone mass. Annals Of The New York Academy Of Sciences, 1192, 170-175. Stalnacke, B.M. (2011). Life satisfaction in patients with chronic pain – relation to pain intensity, disability, and psychological factors. Neuropsychiatric Disease and Treatment, 7, 683-689. Tunca Yılmaz, Ö., Yakut, Y., Uygur, F., Uluğ, N. (2011). Tampa Kinezyofobi Ölçeği`nin Türkçe versiyonu ve Test-tekrar Test Güvenirliği. Fizyoterapi Rehabilitasyon Dergisi, 22(1), 44-49. Heuts, P.H.T.G., Vlaeyen, J.W.S., Roelofs, J., Bie, R.A., Aretz, K., Weel, C. and others. (2004). Pain-related fear and daily functioning in patients with osteoarthritis. Pain, 110, 228–235. Hübscher, M., Vogt, L., Schmidt, K., Fink, M., Banzer, W. (2010). Perceived pain, fear of falling and physical function in women with osteoporosis. Gait &amp; Posture, 32, 383–385. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4796
AB0944 Us Investigation of Gleno-Humeral Joint by Anterior Access: Table 1.
Authors: A.P. Rozin, K. Toledano, A. Dagan, A. Balbir-Gurman
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> US scan was shown to be effective and useful for investigation of gleno-humeral joint (GHJ) synovitis by posterior and axilar (inferior) access (1,2). Synovial fluid in the subacromial bursa and biceps tendon is also associated with GHJ inflammation (3). Anterior access for GHJ assessment has not been investigated. Rotator interval (RI) is the intra-articular triangular space in the upper anterior part of the biceps bed between supraspinatus (SST) and subscapularis (SSC) tendons. The RI is covered with the GHJ capsule and reflects articular processes. <h3>Objectives</h3> To measure GHJ parameters and rotator interval from anterior access and to compare to data from posterior and inferior access. <h3>Methods</h3> Twenty healthy controls (M:F=15:5, age of 45.1±11.2) and 16 patients (M:F=5:11, age of 54.6±14.7) with active rheumatoid arthritis (RA) (DAS28 4.6±1.2) were investigated (Sonosite-Titan, linear 5-10 MHz probe 9L38). In order to make GHJ visible on anterior access we used the original GHJ opening maneuver: supine body position, the adducted to the body elbow and flexed 90 degree on the bed, maximal external shoulder rotation (forearm on the bed). Three structural points are essential for anterior GHJ visualization: 1.A round hyperecoic humeral head; 2. GHJ anecoic cartilage +/- fluid (synovitis); 3. subcscapular tendon situated forward to the GHJ cartilage. The GHJ width was measured for every transducer position at two points. The positions were as follow: posterior transversal, inferior longitudinal, anterior longitudinal along the articular line, anterior transfersal upper, middle and lower. The joint width included thickness of cartilage + synovial fluid/pannus. RI width (SST - SSC) and height (upper biceps channel) were measured. <h3>Results</h3> See Table 1. Our normal GHJ values by posterior and inferior access were within previously estimated range (posterior GHJ width &lt;2.0mm, inferior &lt;3.0mm) (1,2). We acquired the first values of GHJ width from anterior access. The last were within a range of &lt;1.5-1.7mm for healthy controls. Patients with RA showed significantly enlarged joint cavity in posterior, inferior and anterior access. RI was not inflamed. Posterior and inferior data of GHJ width correlated significantly (p=0.01). The data did not correlate with anterior values (p=0.44, 0.56). Synovitis was much more prominent in posterior, upper anterior transversal and anterior longitudinal transducer positions. <h3>Conclusions</h3> The GHJ may be visualized by anterior access using a special maneuver. Synovitis in the anterior region of GHJ may develop at an independent rate. Anterior GHJ sonography may be complimentary to the classic access. <h3>References</h3> Van Holsbeeck MT, et al. Musculoskeletal ultrasound. Mosby, St. Luis. 1991. Koski JM. Scand J Rheumatol 1991;20:49-51. Ptasznik R. Sonography of the shoulder. 2001. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2010
SP0184 How to Treat/Manage Juvenile Idiopathic Arthritis JIA and Other Paediatric Diseases
Authors: M. Hofer
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Inflammatory rheumatism is one of the leading causes of chronic diseases in childhood. Over the last two decades, major changes in the treatment strategies of the paediatric patients have led to a significant improvement in control of inflammation, outcome and quality of life. The main rheumatologic inflammatory condition in children and adolescents is Juvenile Idiopathic Arthritis (JIA), a group of 7 different diagnostic categories. Treatment of JIA is usually initiated with non-steroidal anti-inflammatory drugs. In case of oligoarticular involvement, steroid joint injection is the favoured therapy, and polyarticular JIA will be treated by methotrexate. TNF blocking agents (etanercept and adalimumab) and selective costimulation modulator (abatacept) are the first line biological agents for JIA with polyarticular involvement. For systemic-onset JIA, the paediatric form of Still9s disease, IL-1 and IL-6 blocking agents have recently demonstrated highly efficacious to control both systemic and joint inflammation. Despite recent trials, a number of new molecules are still used off-label in children. Furthermore, many inflammatory rheumatisms in children are rare diseases, and only few or even no new treatments have been registered for these indications. Biological agents are well tolerated in paediatric patients, but long-term safety of these drugs is still unknown. Cohorts of paediatric patients treated by DMARDs and/or biological agents are needed to assess safety and efficacy of the new therapies into adulthood. Two specific aspects of paediatric management are the high prevalence of asymptomatic uveitis, for which a regular screening should be performed, and the need for a structured transition to adulthood. <h3>Disclosure of Interest</h3> M. Hofer Grant/Research support from: Novartis, Pfizer, Abbvie, Consultant for: Novartis <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6342
Abstract 206: A single nucleotide polymorphism (SNP) rs35301225 (A/C/T) in pre-miR-34a alters the cell cycle regulation
Authors: Anvesha Srivastava, Malathi Ramalinga, Simeng Suy, Sean P. Collins, Deepak Kumar
Journal: Cancer Research (2012)

Abstract Prostate cancer (PCa) is the most common type of cancer in men in the United States and is expected to result in ∼218,000 new cases and about 32,000 deaths in 2010. Recently, microRNA miR-34a has been associated with many cancers including prostate cancer. It has been shown that tumor suppressor p53 transcriptionally regulates the expression of microRNA- miR-34a, which confers translational inhibition and mRNA degradation of genes involved in cell cycle control and apoptosis. Several GWAS studies have reported that Single nucleotide polymorphisms (SNPs) in microRNA coding genes (both in seed and mature sequence) or their target binding sites may alter the strength of miRNA binding and deregulate target gene expression. To our interest we aimed to explore the effect of germ line polymorphism rs35301225 (A/C/T) residing in miR-34a (rs35301225) on the cell cycle progression and apoptosis. Prostate (PC3 and LnCap) and breast cancer (MDA-MB 231) cell lines were transfected with pre miRNA mimics containing A/C/T alleles (rs35301225) of miR-34a and the expression of CYCLIN D1, CDK4, CDK6 and proteins associated with cellular signaling cascades, involved in cell cycle regulation were determined by Western blotting. Luciferase assay was performed for the target evaluation. The cell proliferation and apoptosis were measured by WST-1 assay and flow cytometry respectively. The expressions of apoptosis-related proteins were detected by Western blotting in the transfected cells. Western blot analysis showed that CYCLIN D1, CDK4, CDK6 and other downstream molecules were significantly down-regulated in the presence of C allele, whereas no such reduction of expression was observed in the presence of A or T allele. Cell proliferation assay showed that different alleles of miR-34a also exert profound effect on proliferation pattern of cells. Flow cytometry analysis also showed that cells with different alleles of miR-34a may exert significant effect on cell cycle progression and apoptosis. To explore if this phenomenon was confined to prostate cancer cell lines or different alleles of mir-34a may alter cell function in general, experiments were repeated with a breast cancer cell line, MDA-MB-231. Interestingly the results obtained in breast cancer cell lines were similar to that obtained in prostate cancer cell lines. The results suggest that genetic variants residing in the mature miRNA may exert a substantial effect on their expression and function, which needs to be explored along with the biological effect of miRNAs. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 206. doi:1538-7445.AM2012-206
PHARMACODYNAMIC AND PHARMACOKINETIC PROFILES OF PRASUGREL IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION: A RANDOMIZED COMPARISON OF STANDARD VERSUS CRUSHED FORMULATION - THE CRUSH STUDY
Authors: Fabiana Rollini, Francesco Franchi, Jenny Hu, Megha Kureti, Niti Aggarwal, Ashwin Durairaj, Yongwhi Park, Michael Seawell, Pedro Cox-Alomar, Martin Zenni, Luis A. Guzman, Siva Suryadevara, Patrick Antoun, Theodore Bass, Dominick Angiolillo
Journal: Journal of the American College of Cardiology (2016)
Local therapy and overall survival for stage IV breast cancer: SEER 1988-2010.
Authors: Alexandra Thomas, Seema Ahsan Khan, Mary C. Schroeder, Elizabeth A. Chrischilles, Ingrid Lizarraga, Sonia L Sugg
Journal: Journal of Clinical Oncology (2014)

1090 Background: There is still discussion regarding the role of surgery and radiation therapy (RT), for women who present with metastatic breast cancer. Methods: We included women who presented with Stage IV breast cancer from 1988-2010, reported to the Surveillance, Epidemiology, and End Results (SEER) program. Microscopically confirmed, first malignant cancers were included. Treatments were categorized: surgery only, RT only, surgery and RT, and no surgery or RT. Kaplan-Meier survival curves were created. Cox models controlled for age, treatment, hormone receptor (HR) status, marital status, year of diagnosis, and tumor size. Surgery and RT were part of the initial therapy. Surgery was to the primary tumor. RT site was not specified. Results: This series included 31,044 women with Stage IV breast cancer. Of these 25% received surgery, 19% received RT, 19% received both surgery and RT and 37% received no surgery or RT. The mean age of women who received surgery and RT was younger than those who received no surgery or RT (59 vs 64, p<0.001). Those who received surgery and/or RT were more likely to be married than those did not (p<0.001). Kaplan-Meier curves revealed that those who received surgery or surgery with RT had better overall survival than those who did not receive either or had RT alone (p<0.001). Age < 45 (HR=0.85), being diagnosed 2006-2010 (HR=0.72), surgery alone (HR=0.70), surgery with RT (HR=0.61), HR positive (HR=0.51), and being married (HR=0.79), conferred survival advantage in our Cox model (all p<0.001). Breast Tumor size ≥ 5 cm increased risk of death (HR 1.35, p<0.001). RT only women tended to have larger breast tumors (p<0.001). Median survival increased overtime, for all treatment groups. Conclusions: In this population-based series, local treatment was associated with longer survival. Median survival, by year of diagnosis, has improved markedly. Total No surgery or RT Surgery RT Surgery and RT 31,044 11,436 7,681 5,808 5,819 Mean age 62 64 62 62 59 Married 43% 39% 45% 41% 49% Mean survival (mo)* 22 16 28 19 31 Median survival (mo)* 13 7 19 11 22 Age <45 18 13 22 13 27 45-64 16 10 22 13 23 65+ 10 5 15 9 18 Diagnosis yr 1988-1995 17 8 22 12 23 1996-2000 18 10 24 14 30 2001-2005 20 13 27 15 35 * Conditional on having died: 91% of women diagnosed 1988-2005 are deceased.
Abstract 4615: Key miRNAs and co-targets in patients of OPSC and OCC
Authors: Shiying Cui, Henan Zhao, Yanfang Ding, Jinyao Zhao, Tie Bi, Jiyong Jiang
Journal: Cancer Research (2012)

Abstract Objectives: To identify the key microRNAs (miRNAs) and their top co-targets in patients of elderly ovarian papillary serous carcinoma (OPSC) patients with advanced stage and ovarian clear cell carcinoma (OCC), for the insight of possible regulation gene and pathway of epithelial ovarian cancer (EOC) prognosis. Methods: The study was opened to patients with primary, previously untreated EOC referred to member institutions. Pathologic diagnosis was confirmed by central review. High-throughput analysis of the miRNA profile in a panel of OCC and OPSC cells was assessed using a microarray platform. The miRNA-targets and possible pathway were predicted by TargetScans, MicroCosm Targets version 5, miRBase and Ingenuity. Finally, the downstream predicated co-target, activating transcription factor 3 (ATF3) was validated by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) and immunohistochemical (IHC) assay. Results: Of the 667 miRNAs analyzed from human, we identified 83 as enriched in the OPSC, and 15 in OCC (P&amp;lt;0.01 for all). Seventeen of 667 miRNAs were significantly expressed with at least 3 fold differences in the OPSC versus OCC. The expression of tree miRNAs (miR-30a*, miR-30e*, miR-505*) were most significantly lower in OCC comparing to elderly OPSC patients with advanced stage. ATF3, the top co-target gene of three key miRNAs mentioned above was highly expressed in OCC lesions, and a stronger distribution was shown in protein level of ATF3 by immunohistochemistry in OCC than OPSC lesions. Conclusions: We identified the key miRNAs that differentially expressed in patients of elderly OPSC with advanced stage and OCC tumors, predicted and validated the most popular co-target shared by the key miRNAs, indicating the possible regulation gene and pathway for EOC prognosis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4615. doi:1538-7445.AM2012-4615
Abstract 1290: O6-methylguanine-methyltransferase modulates glioblastoma angiogenesis and invasion
Authors: Manik Chahal, Siham Sabri, Yaoxian Xu, Konrad Famulski, David Murray, Bassam Abdulkarim
Journal: Cancer Research (2010)

Abstract Background: Glioblastoma (GBM) is the most aggressive primary malignant brain tumor in adults. Approximately 50% of GBM patients are resistant to standard therapy with temozolomide (TMZ) because their tumors express the DNA repair protein O6-methylguanine methyltransferase (MGMT), which repairs tumoral DNA damage induced by TMZ. GBM, a highly vascularized tumor, consistently displays a locally invasive phenotype, which contributes to biological aggressiveness and clinical recurrence. Therefore, use of the anti-angiogenic and anti-invasive agent sunitinib malate could be a promising strategy for GBM treatment. We showed that sunitinib-based treatment significantly improved the response of MGMT-positive, but not MGMT-negative, cells and this differential effect was reversed upon MGMT depletion with O6-benzylguanine. In the present study, we investigated the relationship between the expression of MGMT and the angiogenic and invasive profile of GBM cell lines. Experimental Design: We performed microarray gene expression analysis and quantitative real-time RT-PCR and analyzed the differential expression of transcripts in GBM cell lines with differential expression levels of MGMT: U87 empty vector (MGMT-negative), its counterpart U87/MGMT (MGMT-positive) (stable transfection), and T98G (constitutively expressing MGMT). We also investigated the effect of MGMT expression on GBM angiogenesis by assessing vascular endothelial growth factor (VEGF) secretion and the ability of growth factors secreted in the GBM conditioned media to induce endothelial tube formation in vitro, and the effect of MGMT expression on GBM invasiveness by examining F-actin organization, and migration and invasion in vitro. Results: The gene chip microarray showed differential mRNA expression of transcripts involved in angiogenesis, invasion, and response to sunitinib in U87/MGMT cells compared to U87/EV cells. These results were confirmed for several transcripts by quantitative real-time RT-PCR or western blotting. Additionally, we also showed that MGMT-positive cells have reduced angiogenic and invasive potential compared to MGMT-negative cells based on decreased VEGF bioavailability, decreased endothelial tube formation, altered morphology, and decreased invasion and migration in vitro. Conclusion: Our study is the first to show a direct link between MGMT expression and decreased angiogenicity and invasiveness of GBM cells. This altered phenotype may account for the preferential in vitro efficacy of sunitinib malate in MGMT-positive GBM cell lines. Our data provide the rationale to further investigate the role of MGMT in the regulation of the angiogenic and invasive profile of GBM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1290.
Tc-99m–Labeled Red Blood Cell Scanning Localizes Anastomotic Hemorrhage Between the Distal Ileum and Duodenal Stump of an Enteric-Drained Pancreas Transplant
Authors: JULIANA BINGENER-CASEY, ROBERT M. ESTERL, W. KENNETH WASHBURN, FRANCISCO G. CIGARROA, GREG A. ABRAHAMIAN, GLENN A. HALFF
Journal: Clinical Nuclear Medicine (2002)

BINGENER-CASEY, JULIANA M.D.; ESTERL, ROBERT M. Jr., M.D.; KENNETH WASHBURN, W. M.D.; CIGARROA, FRANCISCO G. M.D.; ABRAHAMIAN, GREG A. M.D.; HALFF, GLENN A. M.D. Author Information
RIGHT VENTRICULAR DYSSYNCHRONY IMPROVES AFTER PULMONARY THROMBOENDARTERECTOMY IN CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Authors: Darrin Wong, Omid Yousefian, William Auger, Michael Madani, Mary Dittrich, Lori Daniels, Ajit Raisinghani, Anthony DeMaria, Daniel Blanchard
Journal: Journal of the American College of Cardiology (2016)
LDL CHOLESTEROL REDUCTION IN ELDERLY PATIENTS WITH THE PCSK9 MONOCLONAL ANTIBODY EVOLOCUMAB (AMG 145): A POOLED ANALYSIS OF 1779 PATIENTS IN PHASE 2, 3 AND OPEN LABEL EXTENSION STUDIES
Authors: Michael Koren, Robert Rosenson, Bobby Khan, Narimon Honarpour, Mary Elliott, Ransi Somaratne, Scott Wasserman, Erik Stroes
Journal: Journal of the American College of Cardiology (2015)
EUS-guided trucut biopsy of hypoechoic intramural tumors of the stomach: a single-center experience in 17 cases
Authors: M Polkowski, W Gerke, A Nasierowska-Guttmejer, Z Nowecki, P Rutkowski, W Ruka, E Butruk
Journal: Endoscopy (2006)

The aim of this prospective study was to assess the diagnostic yield and safety of EUS-guided trucut biopsy (TCB) in patients with hypoechoic intramural tumors (HITs) of the stomach.
Long-Term Follow-up of von Recklinghausen Neurofibromatosis
Authors: Sven Asger Sørensen, John J. Mulvihill, Arne Nielsen
Journal: New England Journal of Medicine (1986)

To document the natural history of von Recklinghausen neurofibromatosis, we followed up a nationwide cohort of 212 affected patients and families identified in Denmark 42 years ago. We obtained follow-up information on 99 percent. Because all 76 probands were identified through hospitals, they may include a disproportionate number of severe cases of neurofibromatosis. To diminish this effect of selection bias, we distinguished between the probands and their affected relatives. In a comparison with the general population, survival rates were significantly impaired in relatives with neurofibromatosis, worse in probands, and worst in female probands. Malignant neoplasms or benign central nervous system tumors occurred in 45 percent of the probands, giving a relative risk of 4.0 (95 percent confidence limits, 2.8 to 5.6) as compared with expected numbers. Multiple primary neoplasms were found in 15 probands, but only 1 relative. Compared with the general population, male relatives with neurofibromatosis had the same rate of neoplasms, whereas female relatives had a nearly twofold higher rate (relative risk, 1.9; 1.1 to 3.1). Nervous system tumors were disproportionately represented. We conclude that patients with severe neurofibromatosis requiring hospitalization often have a poor prognosis, but incidentally diagnosed relatives may have a considerably better outcome. (N Engl J Med 1986; 314:1010–5.)