tbuckley/cabot-search huggingface dataset:
Consequences of modifying an adjuvant treatment protocol for resected gastric carcinoma: A retrospective study at a single institution in western Canada
Authors: D. G. Bebb, O. Ziouzina, S. Lupichuk, M. Stefaniuk, S. Dowden, A. Chan, B. Walley, S. Chan, A. Wong, C. Doll
Journal: Journal of Clinical Oncology (2007)

15176 Background: Gastric adenocarcinoma has a poor outcome: surgical resection alone in stage IA-IVA is curative in &lt; 30%. Adjuvant chemo-radiotherapy (INT-0116 protocol) increases median overall survival from 27 to 36 months but is associated with high morbidity with many patients requiring protocol modifications to complete treatment. The benefit of modified protocols in this setting has not been well studied. We set out to compare the morbidity and mortality of the INT-0116 protocol with that of modified protocols in a single institution in Western Canada. Methods: We conducted a retrospective review of stage IA-IVA gastric adenocarcinoma patients treated with adjuvant chemo-radiation at our institution after curative-intent surgical resection. Patients were identified from Tom Baker Cancer Centre records. End points were: survival, completion of therapy, local, regional and distant failure. The modified protocol was defined as: combined modality component postponed from the second to the third or fourth chemotherapy cycle or radiation given alone after two or three cycles of chemotherapy. Results: Twenty three consecutive patients were identified; 11 received standard protocol, twelve a modified protocol. Demographic characteristics / staging at resection of those two groups did not significantly differ. Outcomes are summarized in Table 1 . Conclusions: Many patients were unable to complete the INT-0116 protocol as described, while patients placed on a modified protocol had a greater chance of completing treatment. Survival at 12 and 36 months in patients treated with the modified protocol was at least as good as those who underwent the standard protocol. This limited study at a single institution suggests that modifying the INT 0116 protocol can make this treatment more palatable to patients while not compromising outcome. Further research is warranted. Data on a further nine patients more recently treated is being analyzed and will be presented. [Table: see text] No significant financial relationships to disclose.
Abstract 3447: Tetrac (tetraiidothyroacetic acid) decreases in vitro x-ray survival of a human medullary thyroid cancer cell line under oxic and hypoxic conditions
Authors: Aleck A. Hercbergs, Faith B. Davis, Paul J. Davis, John T. Leith
Journal: Cancer Research (2012)

Abstract In 2009 we showed that 2 µM tetrac given for 1 hour at 37oC prior to 250 kVP x-irradiation sensitized GL261 murine brain tumor cells. Radiosensitization was accomplished by increasing the alpha component in the linear-quadratic equation of cell survival (Cell Cycle, 8:2586-91). In 2011, we showed that tetrac also sensitized U87MG human brain tumor cells to 250 kVp x-rays (Cell Cycle, 10: 352-57). Again radiosensitization was accomplished by an increase in the αx-ray component. Tetrac also inhibited the repair of DNA double strand breaks in U87MG cells. However, tetrac which binds to the αvβ3 integrin receptor and inhibitssignaling from the αvβ3 receptor, penetrates the cell and has a thyromimetic effect which offsets radiosensitization. In this regard, we synthesized a nanoparticle tetrac formulation termed Nano-T. Nano-T also binds to the αvβ3 receptor but does notpenetrate the cell. Nano-T causes radiosensitization in vitro in H522 lung cancer cells, producing an added benefit compared to tetrac. We have also shown that daily treatment of in vivo human-MTC (h-MTC) solid tumors in mice with Nano-T for 20 days produced significant growth inhibition. It is our intent to combine Nano-T with ionizing radiation in vivo, and we have begun by studying the effects of tetrac on h-MTC cells in vitro. These h-MTC cells are show an in vitro cell culture doubling time of 96.2 hours and a clonogenicity of 3.16%. We irradiated cells in exponential growth with 250 kVp X-rays. Below we give the LQ survival parameters, and the surviving fraction at 2 Gy (SF2). Table 1. Initial Results of 250 kVp Single Dose X-irradiation on h-MTC CellsIn Vitro without and with Tetrac ≤ α SF2 Tetrac Oxygen (Gy-1 x 10-1) (Gy-2 x 10-2) Enhancment Enhancement Factor Factor Without Tetrac Oxic Cells - 0.033 0.0256 0.901 2.55 Hypoxic Cells 0.030 0.0023 0.922 With Tetrac Oxic Cells 0.472 0.0495 0.330 2.84 2.60 Hypoxic Cells 0.013 0.0256 0.803 2.84 First, h-MTC cells irradiated as oxic or hypoxic, exponentially growing cells are very radioresistant suggesting a large capacity to repair radiation damage. Second, tetrac sensitized both oxic and hypoxic h-MTC cells. These characteristics speak to our proposed Nano-T in treatment of h-MTC tumors in vivo. Nano-T should increase the radiosensitivity of both oxic and hypoxic cells and should also decrease the repair of radiation damage in conventional fractionated radiation therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3447. doi:1538-7445.AM2012-3447
THU0088 Fetuin-A and Its Association with Disease Activity in Psoriatic Arthritis: Table 1.
Authors: S. Ozturk, M. Keser, D. Kozaci, P. Cetin, N. Gunay, F. Onen, N. Akkoc, I. Sari
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Increased risk of cardiovascular morbidity and mortality has been reported in psoriatic arthritis (PsA), a member of a spondyloarthropathy. Fetuin-A is a novel biomarker related with vascular calcification and atherosclerosis. In recent years there is a considerable interest regarding fetuin-A and atherosclerosis. In this respect it has been studied in some rheumatic disease including rheumatoid arthritis. However, available data regarding the association of fetuin-A and inflammatory rheumatic diseases is still limited. <h3>Objectives</h3> In this study we aimed to investigate the association between fetuin-A, disease activity and PsA. <h3>Methods</h3> 97 non-diabetic PsA patients who fulfilled the CASPAR criteria and 57 age and sex matched healthy controls were included in the study. Disease activity was assessed by using Composite Psoriatic Disease Activity Index (CPDAI). Patients were also evaluated with BASFI, BASDAI, DAS28-CRP, HAQ. PASI scores were calculated. Serum lipids, hsCRP, ESR, and fetuin-A were studied. <h3>Results</h3> There were 97 PsA patients (48 [25-65] years, 32M/65F) and 57 healthy subjects (43 [31-57] years, 24M/33F). Disease duration of the PsA patients was 4 (0-43) years. Age, sex distributions, anthropometric measures such as body mass index were similar between the groups. Biochemical parameters such as fasting glucose, lipids (triglyceride, total, LDL and HDL), creatinine clearance were not different PsA patients and controls. On the other hand hs-CRP and ESR were significantly higher in the patients9 group. Fetuin-A concentrations were significantly lower in the patients than in controls (Table 1, P&lt;0.001). When the PsA group was divided into peripheric (n=14), axial (n=52) and both peripheric and axial subtypes (n=31) fetuin A remained significantly lower in the each PsA group compared to controls (peripheric: 1122 [571-1493], axial 1172 [456-2017] and both peripheric and axial subtypes 1113 [486-1580] vs. controls 1442 [63-1896]; P&lt;0.05). On the other hand, there were no differences between the PsA groups regarding fetuin A. There were significant correlations (P&lt;0.05) between fetuin-A concentrations and CPDAI, PASI, hs-CRP and ESR (-0.26, -0.25, -0.3, and -0.26 respectively). However, fetuin-A did not show correlations with BASFI, BASDAI, HAQ and DAS28-CRP. <h3>Conclusions</h3> Fetuin-A levels were significantly down-regulated in PsA patients regardless of the involvement type. Correlations between fetuin-A, acute phase proteins and disease activity indices suggest that inflammation driven mechanisms are reponsible from this condition. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4473
Abstract 5521: IL13 linked lipsomal doxorubicin for malignant peripheral nerve sheath tumors
Authors: Achuthamangalam B. Madhankumar, Becky Slagle-Webb, Annie Park, Marianne Klinger, Min Pang, Kimberly Harbaugh, Jonas M. Sheehan, James R. Connor
Journal: Cancer Research (2010)

Abstract We have previously demonstrated the therapeutic effect of interleukin-13 (IL13) linked liposomal doxorubicin (IL13LDXR) on glioma tumors. These tumors selectively overexpress IL13 receptor α2, a receptor for IL13. In our subsequent study, we found that malignant peripheral nerve sheath tumors (MPNST) also express the receptor for IL13. This observation prompted us to investigate the therapeutic value of IL13LDXR in a MPNST model. IL13LDXR was formulated and characterized in our laboratory using our previously established method. In vitro binding and internalization studies and subsequent fluorescence microscopy demonstrated the effective nuclear delivery of the doxorubicin in the MPNST cells expressing IL13Rα2 receptor. The cytotoxic potential of IL13LDXR was demonstrated in MPNST cell lines sNF96.2, ST88-14 and #215. Immunohistochemistry was performed on malignant and benign peripheral nerve sheath tumor (PNST) sections ex vivo to determine the expression of IL13Rα2 receptor. In addition we also demonstrated the expression of P-glycoprotein, a multidrug resistant protein in MPNST cell lines by immunocytochemistry. We also studied the effect of IL-13 protein in altering the expression of Pgp expression in established MPNST cell lines. We confirmed by an immunoblot that IL13 protein at 5µM concentration was able to decrease the Pgp expression in ST88-14 and sNF96.2 cells. This may explain the mechanism by which the IL-13 conjugated liposomes can deliver the encapsulated doxorubicin in a much more effective manner to drug resistant MPNST cell lines. We investigated the correlation of IL13Rα2 receptor expression with P-glycoprotein a drug resistance associated protein by immunocytochemistry. We confirmed the expression of IL13Rα2 in PNST tumors and established MPNST cell lines. We attempted to develop a MPNST tumor model in athymic nude mice by matrigel implantation method. We administered a single injection of 15 mg/kg of IL13 linked liposomal doxorubicin in a mouse tumor model by intraperitoneal route and observed the selective accumulation of doxorubicin in the tumor by endogenous fluorescence of doxorubicin, whereas no fluorescence was observed in the normal skin region as observed under fluorescence microscope. In conclusion consistent expression of IL13Ra2 receptors in PNST and MPNST cells and tissues indicate a viable approach to use this receptor as a target for MPNST therapy. The doxorubicin accumulation property and its cytotoxic potential on MPNST cells when delivered though the targeted liposomes envisage IL13LDXR as a potential drug for MPNST. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5521.
Absence of Toxicity of Oats in Patients with Dermatitis Herpetiformis
Authors: Catherine M. Hardman, Jennifer J. Garioch, Jonathan N. Leonard, Huw J.W. Thomas, Marjorie M. Walker, Jennifer E. Lortan, Angela Lister, Lionel Fry
Journal: New England Journal of Medicine (1997)

People with gluten sensitivity should avoid foods containing wheat, rye, and barley, but there has been debate about whether they should avoid oats. Although patients with celiac disease have recently been shown to tolerate oats, less is known about the effects of oats on patients with dermatitis herpetiformis.We studied seven men and three women (mean age, 58 years) with biopsy-confirmed dermatitis herpetiformis. They had followed a strict gluten-free diet for a mean of 15.8 years, which controlled their rash and enteropathy. The patients added oats that were not contaminated with gluten to their diets for 12 weeks (mean [+/-SD] daily intake, 62.5+/-10.8 g).None of the patients had any adverse effects. Serologic tests for antigliadin, antireticulin, and antiendomysial antibodies were negative before oats were introduced into the diet and after they were discontinued. Villous architecture remained normal: the mean (+/-SE) ratio of the height of villi to the depth of crypts was 3.59+/-0.11 before the diet and 3.71+/-0.09 afterward (normal, 3 to 5), and the mean enterocyte heights were 31.36+/-0.58 microm and 31.75+/-44 microm, respectively (normal range, 29 to 34). Duodenal intraepithelial lymphocyte counts all remained within normal limits (mean, 13.8+/-1.03 per 100 enterocytes before the diet and 14.2+/-1.2 per 100 enterocytes afterward; normal range, 10 to 30). Dermal IgA showed no significant changes.Patients with dermatitis herpetiformis can include moderate amounts of oats in their gluten-free diets without deleterious effects to the skin or intestine.
TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)
Authors: M. Borad, S. Reddy, N. Bahary, H. Uronis, D.S. Sigal, A.L. Cohn, W. Schelman, J. Stephenson, C. Eng, D.P. Ryan
Journal: Annals of Oncology (2012)
434 HEMATOPOIETIC AND ENDOTHELIAL PROGENITOR CELLS AND GROWTH FACTORS IN HUMAN ACUTE HEPATITIS
Authors: E. Solanas, F.J. Aranguren, J. Godino, J.A. Moreno, M.A. De Gregorio, J.C. Segovia, I. Orman, S. Lorente, M.T. Serrano
Journal: Journal of Hepatology (2012)
Assumptions were confusing
Authors: P. Van Damme, E. Van Doorslaer, G. Tormans, P. Beutels
Journal: BMJ (1995)

EDITOR,—We have performed economic evaluations of prophylaxis against hepatitis A in travellers, and two of R H Behrens and J A Roberts's main conclusions1 are in line with our findings2 3—namely, that hepatitis A vaccination is not cost saving for the average traveller and that vaccination becomes more cost effective than immunisation with human immunoglobulin when the expected frequency of travel exceeds two occasions in the …
Rate Control Efficacy in Permanent Atrial Fibrillation: Successful and Failed Strict Rate Control Against a Background of Lenient Rate Control
Authors: Hessel F. Groenveld, Jan G.P. Tijssen, Harry J.G.M. Crijns, Maarten P. Van den Berg, Hans L. Hillege, Marco Alings, Dirk J. Van Veldhuisen, Isabelle C. Van Gelder
Journal: Journal of the American College of Cardiology (2013)
924 EVIDENCE OF EFFECTIVE INTRALESIONAL DIFFUSION OF ALBENDAZOLE SULFOXIDE IN PATIENTS WITH LIVER ALVEOLAR ECHINOCOCCOSIS
Authors: F. Grenouillet, M.P. Brientini, C. Richou, D. Montange, G.A. Mantion, E. Chatelain, D.A. Vuitton, L. Millon, S. Bresson-Hadni
Journal: Journal of Hepatology (2013)
S134 Comparison of Specific Inhalation Challenge (SIC) with Oasys Analysis of Serial PEF Analysis in the Diagnosis of Occupational Asthma: Abstract S134 Table 1
Authors: VC Moore, PS Burge
Journal: Thorax (2012)

<h3>Aims</h3> to compare Specific inhalation challeng (SIC) with serial measurements of PEF in the diagnosis of occupational asthma Methods; All workers having SIC with occupational agents over a 3 year period were included. Their serial PEF records made during exposure to the suspected agents where analysed using Oasys software. Positive records were those with any of the following; Oasys score &gt;2.5; ABC score ≥15litres/min/hr or timepoint ≥1 non-waking reading Results; 211 challenges were done in 51 workers. 45/51 kept serial PEF records suitable for Oasys analysis. SIC and Oasys analysis were concordant in 17/45 (38%), particularly those exposed to isocyanates or metal-working fluids. SIC was positive in 5 workers with equivocal Oasys analysis in line with its known sensitivity of c70–80%. 12 workers had negative or non-asthmatic SIC responses with positive Oasys analysis. Further investigation showed that occupational asthma was the most likely diagnosis. Negative SIC responses were due failure to identify the correct causative agent or problems with reproducing the work exposures. This was a particular problem with cleaning agents where a protein source may be needed to convert chlorine-releasing agents to chloramines (as shown in swimming pool asthma). Nine workers had equivocal challenges and clearly positive Oasys analysis, helping to clarify the diagnosis in this group, again non-standard agents were common in this group. <h3>Conclusion</h3> SIC and serial PEF analysis are complementary methods for validating a diagnosis of occupational asthma. SIC has particular problems when methods of exposure for newer agents have not been fully developed, Oasys analysis lacks sensitivity when current specificity is fixed at &gt;90%.
Preinfarction Angina as a Predictor of More Rapid Coronary Thrombolysis in Patients with Acute Myocardial Infarction
Authors: Felicita Andreotti, Vincenzo Pasceri, David R. Hackett, Graham J. Davies, Agha W. Haider, Attilio Maseri
Journal: New England Journal of Medicine (1996)

When a myocardial infarction is preceded by angina, the infarct tends to be smaller than when there is no preinfarction angina. Prompt recanalization of the occluded infarct-related artery is crucial in limiting the size of the infarct. We prospectively studied the relation among preinfarction unstable angina, the speed of coronary reperfusion, and the size of the infarct in patients with acute myocardial infarction receiving thrombolytic therapy.
AB0224 Oaz regulate B-cell functions through the inhibition of CCL2 expression in mesenchymal stem cells
Authors: X. Feng, N. Che, Y. Liu, D. Wang, L. Sun
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Mesenchymal stem cells (MSCs) had been indicated to exert suppressive effects on B-cell proliferation and differentiation through released humoral factor(s) yet to be defined, which is impaired in patients with systemic lupus erythematosus (SLE). Our data showed that Olf1/EBF associated zinc finger protein (OAZ), a recently indentified lupus susceptibility gene involving in the production of antinuclear antibody (ANA), highly expressed in MSCs especially those from SLE patients, suggesting a role of this gene in the regulation of MSC-B cell functions. <h3>Objectives</h3> To find out how OAZ act to affect MSC-B cell regulations. <h3>Methods</h3> Splenic B cells from MRL/lpr lupus mice were purified using anti-CD43 antibody and immunomagnetic beads. MSCs from bone marrow of SLE patients or healthy donors were isolated and expanded by culturing for 3-4 passages. MSCs (1: 10) were seeded in wells 6-8 hours before adding B cells, then co-cultured for 3 days with lipopolysaccharide in a tissue culture incubator. The effect of MSC on the proliferation of B cells was evaluated by using BrdU assay, and the B-cell differentiation was established using flow cytometry based on the expression of CD19 and CD138. Some of the wells were incubated with siRNAs targeting human OAZ (using non-targeting sequence as negative control) or anti-CCL2 neutralizing antibody (using isotype Ig as control). Cultured supernatants were harvested and measured for ANA as well as IgG levels by ELISA. <h3>Results</h3> Compared to normal MSCs, high percentages of BrdU positive cells and CD19+CD138+ cells were detected when mouse B cells were co-cultured with MSCs from SLE patients. Silencing of human OAZ partially restored the ability of SLE MSCs to inhibit B cells proliferation and differentiation by 51.2% and 69.4% respectively. Meanwhile, a decline of ANA and total IgG was also observed. The level of CCL2, a MSC-derived chemokine involved in plasmablast proliferation that dramatically lowered in supernatants of SLE MSCs–mouse B cells co-cultures, was elevated after OAZ silencing. When anti-CCL2 antibody was added to the co-culture system with OAZ silenced, percentages of BrdU positive cells and CD19+CD138+ cells were both significantly increased. <h3>Conclusions</h3> Elevated expression of OAZ could weaken the inhibitory function of MSCs on B cells through the reduction of MSC-derived CCL2 secretion, thus contribute to the onset of SLE. <h3>Disclosure of Interest</h3> None Declared
Visualization of Protein Losing Enteropathy in Infantile Systemic Hyalinosis With Tc-99m HSA After Albumin Challenge
Authors: EPPIE SHIELDS, TORY TUCKER, WILLIAM MEYERS, CHARLES J. CHUNG
Journal: Clinical Nuclear Medicine (1996)

A 5-month-old girl with diarrhea, irritability, and dehydration was admitted and placed on a restricted protein intake. Tc-99m HSA imaging showed no evidence of a protein losing enteropathy. The patient was given albumen replacement and repeat Tc-99m HSA imaging demonstrated activity in the small bowel and colon. The patient was diagnosed to have infantile systemic hyalinosis, a disease characterized by painful joint contractures, persistent diarrhea, and presence of hyaline material in the dermis. This case suggests the need for “albumin challenge” in detecting protein losing enteropathy if protein intake had been severely restricted.
Metformin for women with hyperandrogenic anovulation
Authors: Wellington P. Martins
Journal: Human Reproduction Update (2016)

Stella Iacovides, Paivi Polo-Kantola, and Fiona C. Baker Wits Sleep Laboratory, Brain Function Research Group, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Department of Obstetrics and Gynaecology, Turku University Hospital and University of Turku, Turku, Finland Human Sleep Research Program, SRI International, San Francisco, CA, USA doi:10.1093/humupd/dmv062 Advanced Access Publication on January 10, 2016 Metformin for women with hyperandrogenic anovulation
A New<i>Chlamydia psittaci</i>Strain, TWAR, Isolated in Acute Respiratory Tract Infections
Authors: J. Thomas Grayston, Cho-chou Kuo, San-pin Wang, Jeff Altman
Journal: New England Journal of Medicine (1986)

During a 2 1/2-year period, we studied 386 University of Washington students with acute respiratory disease, to determine whether a Chlamydia psittaci strain, here designated TWAR, is an important respiratory pathogen. Serologic evidence of recent TWAR infection was found in 13 students, and the organism was isolated from 8 of these. TWAR infection occurred in 12 percent of the students who had pneumonia (9 of 76), 5 percent of those with bronchitis (3 of 63), and 1 percent of those with pharyngitis (1 of 150). The TWAR infections occurred throughout the study period. Pharyngitis, often accompanied by laryngitis, was a common first symptom. Clinically, the infections resembled those with Myco-plasma pneumoniae; therefore, the patients were given courses of erythromycin used for the treatment of M. pneumoniae infections. This therapy proved to be inadequate. The limited data available suggest that the TWAR strain is a "human" C. psittaci that is spread from human to human, without a bird or animal host.