tbuckley/cabot-search huggingface dataset:
Surveillance status and recent data for Mycoplasma pneumoniae infections in the European Union and European Economic Area, January 2012
Authors: A Lenglet, Z Herrador, A P Magiorakos, K Leitmeyer, D Coulombier, Collective European Working Group on Mycoplasma pneumoniae surveillance
Journal: Eurosurveillance (2012)

In January 2012, the European Centre for Disease Prevention and Control (ECDC) conducted an email based survey of European Union and European Economic Area countries to describe the existing surveillance activities for Mycoplasma pneumoniae infections, recent findings and existence of clinical guidelines for the treatment of M. pneumoniae infection. Of the 20 countries that participated in the survey, seven reported increases in M. pneumoniae infections observed during the autumn and winter of 2011.
PTH-244 Obscure gastrointestinal bleeding: are long acting somatostatin analogues a useful adjuvant treatment? results from a tertiary centre
Authors: D Rattehalli, DS Sanders, ME McAlindon, R Sidhu
Journal: Gut (2015)

<h3>Introduction</h3> Small bowel vascular lesions are a common cause of obscure gastrointestinal (GI) bleeding, particularly in the elderly. Enteroscopy for argon plasma coagulation (APC) can be difficult and a proportion of patients continue to have recurrent bleeding despite endoscopic therapy. Pharmacological drugs are useful adjuvant treatment. The aim of this study was to assess the role of long acting somatostatin analogues (lanreotide) in patients with refractory GI bleeding. <h3>Method</h3> We retrospectively evaluated the effect of lanreotide in patients with refractory GI bleeding. Baseline demographics, co-morbidities, medications and previous endoscopic therapy were recorded. Efficacy was evaluated in terms of improvement in mean haemoglobin, transfusion requirements and bleeding episodes (&gt;2 g/dl drop in HB or overt bleeding). <h3>Results</h3> Eleven patients (64% males, mean age 73 years) were treated with lanreotide between 2010–2014. All patients had multiple comorbidities including ischaemic heart disease (n = 10), diabetes (n = 6) and chronic kidney disease (n = 5). Three patients had a diagnosis of hereditary haemorrhagic telangiectasia. Six patients were on anticoagulants and 4 patients on aspirin whilst 4 patients were on transexamic acid. All patients had been requiring regular blood transfusions. The median duration of anaemia was 72 months. Lanreotide was given at a dosage of 60 mg (n = 5), 90mg (n = 3) or 120 mg (n = 3). Nine patients received a monthly dose; 1 patient received a 6 weekly dose and 1 patient received a single dose. The mean duration of treatment was 10.5 months (range 1–29 months). Eight out of 11 patients received endoscopic therapy with APC prior to commencing lanreotide. Four patients had further enteroscopy and APC during the treatment period with lanreotide. There was a significant difference in mean baseline and follow up haemoglobin levels with lanreotide therapy: 8.7 g/dl (7.3–10) vs. 9.7 g/dl (7.9 −11.8); p = 0.03. Transfusion requirements were reduced in all but 2 patients (p = 0.042). Bleeding episodes were reduced during the treatment period (0 episodes (n = 6), 2 episodes (n = 4), 4 episodes (n = 1) (p = 0.02). Fif death was aspiration pneumonia. In the endoscopically managed group, the 30 day mortality was 0%. One year mortality was 33% for the surgical group and 8% in the endoscopically managed group. <h3>Conclusion</h3> Our data suggests that this procedure is safe and effective, particularly when compared to the surgical alternative in this high risk group. The success rate of this procedure was high, suggesting that by utilising this technique, surgery can be avoided in the majority of patients with buried bumper syndrome. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Binnebossal M, Klink CD, <i>et al</i>. Endoscopic Removal of Buried Bumper. Department of Surgery. RWTH Aachen University: Endoscopy. 2010:42:E17–18
A Retrospective Evaluation of Efficacy and Tolerability of Two Different Adjuvant Chemoradiotherapy Regimens in Operable Node-Positive Gastric Carcinoma with D2 Lymph Node Dissection
Authors: T. Ozatli, U.Y. Yalcintas Arslan, A.S. Ekinci, O. Bal, O. Esbah, F. Basal, E. Eraslan, N. Alkis, B. Oksuzoglu
Journal: Annals of Oncology (2014)
Self-portrayal by a depressed poet: a contribution to the clinical biography of William Cowper
Authors: J E Meyer, R Meyer
Journal: American Journal of Psychiatry (1987)

The life of the eighteenth-century English poet William Cowper, who suffered from recurrent major depression, or bipolar II disorder, is described. Since no effective treatment was available, Cowper's writings give an example of the natural history of major depression. They also illustrate the fate of a mental patient of the upper classes at that time. The authors discuss the relevance of Cowper's mother's death during his childhood to his depressive illness and draw attention to the poet's sensitive description of his own psychopathology and the lifelong course of his illness.
Orthopaedic Waiting List Reduction through a Review of Service Provision: The Problems Encountered
Authors: V K Hochuli
Journal: Journal of the Royal Society of Medicine (1988)

Measures to eliminate excessive waiting times for orthopaedic outpatient appointments and inpatient treatment were proposed by a Working Party under the chairmanship of Professor R B Duthie. To implement the proposals reliable information is necessary but a survey in a district found that waiting list numbers were inaccurate, activity statistics under represented work levels and there was scepticism about the accuracy of theatre records. With accurate information and use of the proposed methods a service's efficiency should increase, but problems will remain unless measures of outcome, control of input and accident prevention strategies are devised. In the meantime good management of waiting lists will improve the quality and efficiency of a surgical service.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1976)

A 27-year-old gravida 4, para 3, with a history of two-hour labors underwent elective induction at term. A specific weekend date, suitable for purposes of hospital publicity, was selected jointly by the obstetrician and the administrator.On admission at 7 a.m., the patient reported intermittent mild contractions ever since the membranes had been "stripped" in the office two days earlier. Except for obesity, physical examination was within normal limits, as were vital signs. The fetal head was unengaged, and the cervix was thick and dilated to admit 1 1/2 fingers. Oxytocin, 200 U per tablet, was administered buccally, every half . . .
A biological basis for the Oedipus complex: an evolutionary and ethological approach
Authors: A D Jonas, D F Jonas
Journal: American Journal of Psychiatry (1975)

The authors propose that the Oedipus complex has a strong biological basis that is evident in observations of human prehistoric and nonhuman primate behavior. The groundwork for the oedipal phase is the peaking of human infantile sexuality at age five or six-a vestige of an earlier biological timetable. Other contributing factors include the high level of helplessness of human infants, the resulting high attachment needs, and the prolongation of development phases. Unsuccessful resolution of the oedipal phase may result when the mother's dominant status is lowered. The authors suggest that an understanding of the relationship between sex and rank and an wareness of ethological findings can broaden psychodynamic formulations and enrich the psychoanalytic therapy of sexual problems.
Pertussis surveillance in Switzerland, 1992 to 1997 – a large epidemic in 1994. What next?
Authors: H. C. Matter
Journal: Eurosurveillance (1999)

Cases of whooping cough have been recorded by the Swiss Sentinel Surveillance Network Sentinella (SSSN) since June 1991 to monitor pertussis trends in Switzerland and to assess the current vaccination strategy. The Sentinella network consists of a sampl
Case 24-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, David S. Rosenthal, John C. Long
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 55-year-old woman was admitted to the hospital because of anemia.She was well until three months earlier, when she experienced the insidious onset of weakness, malaise and exertional dyspnea. One month later she began to hear roaring in the ears on recumbency. One month before admission a physician found that she was anemic. A single injection of vitamin B12 was given, without response, and she was referred to this hospital.Twelve years previously one of several enlarged supraclavicular lymph nodes was removed for biopsy; microscopical examination was reported to show hyperplasia. The other enlarged lymph . . .
Editorial
Authors: OSCAR D. RATNOFF
Journal: Circulation (1962)

The Laboratory Control of Anticoagulant Therapy T HE therapeutic aim in the use of the coumarin compounds and of the physiologically similar indanedione compounds is to impede intravascular clotting without indue- ing a significant bleeding tendency.To achieve this goal, therapy is usually monitored by re- peated measurements of the one-stage pro- thrombin time.Nonetheless, hemorrhagic accidents are common.To obviate these diffi- culties, many other procedures have been suggested to measure the extent of the induced hemostatic defect.Recently, a radically new technic, the " thrombotest, " has been proposed to assess the effects of the coumarin-like drugs.Its proponents have claimed that the throm- botest provides greater accuracy and safety than the one-stage prothrombin time.The adequacy of this newer method is by no means established, but it is timely to inquire into its rationale and into the problems that have 1962 NO.
Lithium response in good prognosis schizophrenia
Authors: J Hirschowitz, R Casper, D L Garver, S Chang
Journal: American Journal of Psychiatry (1980)

The authors report the results of a 2-week lithium trial using 31 patients meeting Research Diagnostic Criteria for schizophrenia or schizoaffective disorder who were also diagnosed according to DSM-III criteria. One-third of the patients showed reduction of their schizophrenic-like symptoms during the lithium trial. Seven of the 9 responders (78%) met DSM-III criteria not for schizophrenia but for a schizophreniform disorder. Such patients also met McCabe and associates' criteria for good prognosis schizophrenia. This study lends further support to the growing body of evidence which suggests that schizophreniform disorder and good prognosis schizophrenia may be affective disorders with atypical schizophrenic-like features. The authors cautiously suggest that a lithium trial may be indicated in this subgroup of patients.
Natural Antibody in Human Serum to a Neoantigen in Human Cultured Cells Grown in Fetal Bovine Serum2
Authors: Reiko F. Irie, Kenji Irie, Donald L. Morton
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Natural Antibody in Human Serum to a Neoantigen in Human Cultured Cells Grown in Fetal Bovine Serum Get access Reiko F. Irie, Reiko F. Irie Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenji Irie, Kenji Irie Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald L. Morton Donald L. Morton Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1051–1058, https://doi.org/10.1093/jnci/52.4.1051 Published: 01 April 1974 Article history Received: 02 July 1973 Revision received: 11 November 1973 Accepted: 02 December 1973 Published: 01 April 1974
AB0382 Insulin Resistance in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis – Comparative Study
Authors: P. Dąbrowski, M. Majdan, M. Dryglewska, A. Wadowski
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The increase of insulin resistance (IR) was signaled in rheumatoid arthritis (RA), but its prevalence in ankylosing spondylitis (AS) is not explored.The relationship between the inflammatory process, disease activity and demographic data have been poorly studied up till now. <h3>Objectives</h3> The aim of the study was to assess the prevalence of IR and its relationships with markers of inflammation, disease activity and demographic parameters in patients (pts) with RA and AS. <h3>Methods</h3> 102 patients [60 with RA, 42 with AS] were studied. Average age of patient was 52 [35; 65] in RA and 38,8 [20; 61] years in AS group. Mean BMI – 25,8 [17,6; 36,7] and 24,3 [17,9; 34,9], mean WHR 0,85 [0,66; 1,14], and 0,88 [0,68; 1,1] in RA and AS group.Mean duration of disease - 12,2 [1,0; 36] and 7,8 [1,0; 35] years, respectively. Mean DAS28 - 4,19 [1,41; 7,07], mean BASDAI - 4,01 [0,6; 10].The Homoeostasis Model Assessment (HOMA) and Insulin/Glucose index were used to measure insulin resistance and the Quantitative Insulin Sensitivity Check Index (QUICKI) and Matsuda index to measure insulin sensitivity. The inflammatory disease activity was assessed using measurements of ESR, hs-CRP, IL-6, IL-6sR, SAA. <h3>Results</h3> The indices of IR were significantly higher in RA patients than in those in AS group. The mean values of HOMA-IR were 1,95±1,52 vs. 1,18±0,64 (p&lt;0,01), and I/G 0,11±0,12 vs. 0,05±0,03 (p&lt;0,001). The indices of insulin sensitivity were significantly lower in RA patients - mean QUICKI 0,36±0,03 vs. 0,38±0,03 (p&lt;0,001), mean Matsuda 6,83±3,49 vs. 10,15±5,1 (p&lt;0,001). All of these indices were significantly correlated with BMI and WHR in group RA and with BMI (with WHR only HOMA-IR and I/G) in group AS, however there was no significant difference in terms of WHR and BMI in both groups. In addition, HOMA-IR and QUICKI in group RA were correlated with hemoglobin (Hb) (r=0,33; r= -0,36, p&lt;0,01) and uric acid levels (UA) (r=0,28; r= -0,30, p&lt;0,05). Moreover, the negative correlation between IR and glucocorticoid (GCs) treatment (mean prednison dose 5,4 mg/d) in patients of RA for HOMA-IR and Matsuda index has been shown. There weren9t any associations between the studied parameters and disease activity (DAS28, BASDAI),disease duration, age and acute phase parameters: ESR, hs-CRP,IL-6, IL-6 sR, SAA. Of these parameters hs-CRP and SAA showed a strong correlation with disease activity in RA patients (r=0,59; r=0,63, p&lt;0,001) but not in those with AS. <h3>Conclusions</h3> Insulin resistance occurs more frequently in patients with RA than AS. It was dependent on body weight indices in both cases, whereas not on disease activity as well as markers of inflammation. Acute phase parameters: hs-CRP and SAA strongly correlated with the disease activity in patients with RA. <h3>Disclosure of Interest</h3> None declared
Cervix cancer: too many patients.
Authors: M H Cohen
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.4.755 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2313339 Cervix cancer: too many patients. M H CohenxM H CohenSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.4.755 PDF "Cervix cancer: too many patients.." Journal of Clinical Oncology, 8(4), pp. 755–756© 1990 by American Society of Clinical Oncology
AB1138 Hospitalizations and Mortality in Rheumatoid Arthritis and Systemic Lupus Erythematosus. Impact of Comorbidities
Authors: M.U. Martinez Martinez, C.O. Quintero-Martínez, C. Abud-Mendoza
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Mortality in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) is linked to comorbidities, particularly cardiovascular diseases. Hispanics have higher mortality than other races. <h3>Objectives</h3> To evaluate mortality and comorbidities in admissions to a Mexican hospital in the last 14 years. <h3>Methods</h3> We evaluated all hospitalizations from January 2001 to July 2014 with diagnosis of RA or SLE according to the database of our hospital. All comorbidities were classified according to the International Classification of Diseases (ICD). Analysis was performed using R, version 3.1.2. <h3>Results</h3> We evaluated 1121 hospitalizations, 581 (51.8%) RA, and 540 (48.2%) SLE; mean age of RA patients was 57.1 years, and for SLE patients 29.2 (p&lt;0.0001). Comparing with SLE, patients with RA had higher frequency of diabetes, chronic obstructive pulmonary disease (COPD), systemic hypertension, myocardial infarction, digestive hemorrhage and infections (Table 1). Mortality was similar in both groups. Comorbidities associated with mortality (Figure 1) were CVD (odds ratio of 6.4, confidence interval (CI): 2.3-17.3), heart failure (OR 3.1, CI: 1.3-6.5), digestive hemorrhage (OR 3.5, CI: 1.7-6.9), and infections (OR 2.3, CI: 1.6-3.4). In the logistic regression model adjusted for age and disease (SLE or RA), the OR (CI) were: CVD 6.8 (CI: 2.7-17.5), heart failure 2.3 (1.1-4.9), digestive hemorrhage 3.7 (1.9-7.3) and infections 2.3 (1.6-3.5). <h3>Conclusions</h3> Even the higher frequency of comorbidities and age in RA patients, mortality was similar in SLE Mexican patients. Cerebrovascular and cardiovascular diseases were associated with higher mortality. <h3>Disclosure of Interest</h3> None declared
PWE-024 The colorectal cancer mdt: how many errors occur, do they matter and can they be averted?
Authors: MK Matharoo, R Baldwin, A Haycock, J Jenkins, D Burling, N Sevdalis, S Thomas-Gibson
Journal: Gut (2015)

<h3>Introduction</h3> The colorectal cancer multidisciplinary team (CRC MDT) provides a common pathway for patients from Bowel Cancer Screening (BCS), symptomatic (SYM), 2-week wait (2WW) and tertiary (TER) pathways. These pathways are complex and variable and hence error prone. Improved endoscopic techniques have transformed CRC management but little is known about improvements required for the MDT. Enhancing MDT quality by addressing errors can raise quality assurance at the bridge between diagnostic and therapeutic pathways. Objectives: To prospectively record Patient Safety Incidents (PSIs) identified at CRC MDT across different patient pathways. <h3>Method</h3> Two independent clinical observers prospectively evaluated CRC MDTs in real time. Patients were subcategorised by clinical pathway: BCS, 2WW, SYM and TER. PSIs were noted qualitatively for each patient and subsequently categorised. PSIs were defined as near misses, adverse events and sub-optimal clinical processes negatively impacting the patient’s cancer care. <h3>Results</h3> 412 MDT patient discussions (SYM n = 165, 2WW n = 97, TER n = 97 BCS n = 53) over 27 meetings were prospectively analysed. Medical notes were unavailable for 73 (21%) patients. 146 PSIs were identified: SYM n = 62 (42%), 2WW n = 37 (25%), TER n = 31 (21%), BCS n = 16 (11%). There was a trend towards more errors in the SYM group and fewer in BCS, although there was no significant difference between groups (p = 0.39). Table 1illustrates examples of severe PSIs. Many PSIs related to miscommunication, incomplete clinical data and poor non-technical skills such as leadership and inclusive team discussion. Although many PSIs did not have direct patient consequences they represent areas for improvement to avoid future significant errors. <h3>Conclusion</h3> Multiple errors were observed across the CRC MDT irrespective of patient subgroups. We propose a minimum patient data set and MDT team training in non-technical skills. Further work is underway to categorise PSIs by expert consensus, identify strategies to prevent avoidable error and ensure accountability for correcting errors. Examining PSIs arising outside the MDT provides a valuable opportunity to correct errors in other parts of the cancer pathway that may otherwise go un-noticed. <h3>Disclosure of interest</h3> None Declared.
PTU-024 Photometric stereo reconstruction for surface analysis of mucosal tissue
Authors: A Poullis, C Groves, G Slabaugh, K Emrith, M Smith
Journal: Gut (2015)

<h3>Introduction</h3> The American Society of Gastroenterology endoscopy led Preservation and Incorporation of Valuable endoscopic Innovations initiative has identified real time polyp detection diagnosis as one of the next major technology-driven changes in endoscopy.<sup>1</sup>We have recently described a novel photometric stereo (PS) imaging sensor for endoscopy imaging in a porcine model.<sup>2</sup>Following image acquisition, reconstruction of the surface data is necessary to calculate the shape index (SI) to identify regions that are locally spherical, suggestive of polyps to aid polyp detection. <h3>Method</h3> Using a porcine gut model, photometric images were captured using a six-light source PS setup as previously described.<sup>2</sup>Surface analysis of the obtained surface data was performed: Derivatives of the height fields arranged on a square lattice were calculated using finite differences, and used to characterise the differential geometry using the principal curvatures.<sup>3</sup>Surface measures analysis: for each point on the surface, the shape index (SI) was computed and used to measure the local shape: SI = 1/2 – 1/π tan−1 ((K1+K2)/(K1-K2)) <h3>Results</h3> <h3>Conclusion</h3> Using a novel PS image acquisition 3D reconstruction was obtained on colonic mucosa. We observe that the recovered 3D surface retains the surface geometry in the captured areas and important structural information at a fine level of detail, even in the presence of numerous specular reflections. This is highly significant for automated processing and analysis of surface abnormalities. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Rex, et alet al. Gastrointest Endosc 2011;<b>73</b>:419–22 Poullis, et alet al. Gut 2014;<b>63</b>(Suppl 1):A46 do Carmo M. <i>Differential geometry of curves and surfaces</i>. Prentice Hall, 1976, ISBN:0132125897
Decreased Serum Selenium in Alcoholic Cirrhosis
Authors: P Balcke, P Schmidt, J Zazgornik, H Kopsa, E Deutsch
Journal: New England Journal of Medicine (1980)

The concentration of oxalic acid was determined in the plasma of 15 patients with conservatively treated chronic renal insufficiency and 17 dialysis patients. A cumulation of oxalic acid was found in connection with uraemia. The extent to which plasma oxalic acid concentrations were raised depended on the degree of renal insufficiency and was directly related to the plasma creatinine values in all patients with or without dialysis. In the patients with chronic renal insufficiency the median plasma oxalic acid concentration was 74.4-18.5 (control group 27.0 +/- 7.4) mumol/l. In the dialysis patients the levels were even higher, at 137.5 +/- 56.0 mumol. By means of haemodialysis it was possible to lower the plasma oxalic levels by about the same amount as creatinine concentrations. The higher plasma oxalic acid concentrations seem to be an important pathogenetic factor in the formation of uraemic calcification in various organs. The therapeutic consequences are to increase the duration and frequency of dialysis and to remedy possible vitamin B6 deficiency.