tbuckley/cabot-search huggingface dataset:
Pheochromocytoma in Childhood
Authors: I NASSO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response to the Council of Europe Human Rights Commissioner's Issue Paper on Human Rights and Intersex People
Authors: Martine Cools, Margaret Simmonds, Sue Elford, Joke Gorter, S. Faisal Ahmed, Franco D’Alberton, Alex Springer, Olaf Hiort
Journal: European Urology (2016)

Intersex/disorders of sex development advocacy groups and associated health care professionals question the legitimacy of the Council of Europe issue paper, express their worries about its potentially harmful consequences, and urge the Council of Europe to consult more widely with relevant stakeholders.
The DSM-IV field trial for mixed anxiety-depression
Authors: R E Zinbarg, D H Barlow, M Liebowitz, L Street, E Broadhead, W Katon, P Roy-Byrne, J P Lepine, M Teherani, J Richards
Journal: American Journal of Psychiatry (1994)

This field trial was designed to answer four questions. First, are patients presenting with anxious or depressed symptoms that are associated with significant impairment but do not meet DSM-III-R definitional thresholds for axis I anxiety or mood disorders? Second, is the impairment experienced by these patients simply the consequence of the severity of their medical conditions? Third, what percent of these patients present with depressive symptoms only, anxious symptoms only, and a mixture of both? Fourth, how should the operational criteria for the syndrome(s) presented by these patients be defined?A total of 666 patients from five primary care medical sites and two outpatient mental health sites were administered a semistructured psychiatric interview.Patients presenting with affective symptoms that did not meet definitional thresholds for DSM-III-R axis I disorders were at least as common as patients with several of the already established anxiety and mood disorders in each of the seven sites, and their disorders were associated with significant distress or impairment. A nonspecific pattern of anxious and depressed symptoms was the modal presentation among these patients with currently subdefinitional threshold disorders, and they could be significantly differentiated in terms of current symptoms from patients presenting with a principal diagnosis of generalized anxiety disorder, major depressive episode, or panic disorder with agoraphobia.The authors recommend that a mixed anxiety-depression category be included in the DSM-IV appendix for proposed diagnostic categories that need further study. A criteria set is proposed.
Psychiatric disturbances associated with Erhard Seminars Training: I. A report of cases
Authors: L L Glass, M A Kirsch, F N Parris
Journal: American Journal of Psychiatry (1977)

Erhard Seminars Training (est) is a large-group experience that is becoming widely available in this country. This is the first case report in the professional literature of psychiatric disturbance following est training. Five patients, only one of whom had a history of psychiatric disturbance, developed psychotic symptoms including grandiosity, paranoia, uncontrollable mood swings, and delusions. Further work is necessary to ascertain the factors that determine outcome in est.
An Intermittent Perfusion and Gas Exchange Method for Continuous Cultivation of Cells in the Rose Chamber
Authors: Willie D. Morgan, Clyde J. Dawe
Journal: JNCI Journal of the National Cancer Institute (1961)

A simple technique for providing gas exchange within the Rose tissue-culture chamber is described. The method involves initial introduction of a large gas phase within the chamber, and subsequent maintenance of communication between this gas phase and a gas reservoir by means of polyethylene tubing. The fluid phase is exchanged intermittently by means of a gravity flow system through polyethylene tubes. The gas bubble within the chamber is kept in constant position, away from the microscopic field. We accomplish this by placing the entire apparatus at a slight angle to the horizontal, which creates a spirit-level effect. With this technique it is possible to grow and maintain heavy populations of strains P388 D1, and HeLa cells for periods of 4 and 5 months, respectively. After these intervals the condition of the cells was as good as at the outset and was comparable to that of the same strain carried in tube cultures. There is no apparent time limit for growing cell strains within such chambers. Preliminary trials demonstrated that in this system submandibular gland rudiments of mouse embryos undergo development comparable to that in tube or dish cultures. The advantages of the system are that it permits long-term, time-lapse cinematography, with phase or ordinary optics, at any magnification, of cultures under conditions approximating those in standard tubes or flasks. The technique may be applicable to studies of long-term phenomena such as “spontaneous” or induced morphologic transformation of cells in vitro.
Excretion of Urinary Coproporphyrins in Patients with Neoplastic Diseases Treated with Methyl-Bis(β-Chloroethyl) Amine Hydrochloride (HN2)
Authors: Howard R. Bierman, M. D., Louis A. Strait, Ph.D., Michael K. Hrenoff, B. S.
Journal: JNCI Journal of the National Cancer Institute (1949)

Excretion of Urinary Coproporphyrins in Patients with Neoplastic Diseases Treated with Methyl-Bis(β-Chloroethyl) Amine Hydrochloride (HN2) Get access Howard R. Bierman, M. D., Howard R. Bierman, M. D. Laboratory of Experimental Oncology, National Cancer Institute, National Institutes of Health, Public Health Service, and University of California Medical School, San Francisco Search for other works by this author on: Oxford Academic PubMed Google Scholar Louis A. Strait, Ph.D., Louis A. Strait, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael K. Hrenoff, B. S. Michael K. Hrenoff, B. S. Spectrographic Laboratory, University of California, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 93–103, https://doi.org/10.1093/jnci/10.1.93 Published: 01 August 1949 Article history Received: 18 March 1949 Published: 01 August 1949
What is meant by the term "binge"?
Authors: S J Beglin, C G Fairburn
Journal: American Journal of Psychiatry (1992)

Systematic examination of the use of the word "binge" by 243 young women revealed discrepancies between the lay and technical uses of the term; the young women placed great emphasis on loss of control and less on the quantity eaten. These discrepancies indicate that the term "binge" should be clearly defined in clinical practice.
The human homologue of rat NG2, a chondroitin sulfate proteoglycan, is not expressed on the cell surface of normal hematopoietic cells but is expressed by acute myeloid leukemia blasts from poor-prognosis patients with abnormalities of chromosome band 11q23
Authors: FO Smith, C Rauch, DE Williams, CJ March, D Arthur, J Hilden, BC Lampkin, JD Buckley, CV Buckley, WG Woods, PA Dinndorf, P Sorensen, J Kersey, D Hammond, ID Bernstein
Journal: Blood (1996)
15-Hydroxyeicosatetraenoic acid-mediated potentiation of thrombin- induced platelet functions occurs via enhanced production of phosphoinositide-derived second messengers--sn-1,2-diacylglycerol and inositol-1,4,5-trisphosphate
Authors: BN Setty, MH Werner, YA Hannun, MJ Stuart
Journal: Blood (1992)
PTU-311 Endoscopy in variceal bleeding: optimal time to rescoping
Authors: L Nunn, C Shekhar, R Mohammad, N Fisher, S Ishaq
Journal: Gut (2015)

<h3>Introduction</h3> Variceal haemorrhage is a common and potentially lethal complication of cirrhosis.<sup>1</sup>Variceal rebleeding can occur in 20% of cases in the first week following the acute episode.<sup>2</sup>BSG guidelines published in 2000 suggested endoscopy at weekly interval, whereas the AASLD guideline from 2007 suggest at 1–2 week interval and most recent ASGE guideline suggests optimal rescoping intervals of 1–8 weeks, a wide-ranging time scale recommendation classified as low-grade evidence.<sup>3–5</sup>There is also primary literature that indicates that rescoping in less than 3 weeks might increase risk of harm.<sup>6</sup>We have reviewed our practice to assess compliance with guidelines. <h3>Method</h3> We carried out a retrospective review of endoscopic procedures and follow up after oesophageal variceal bleeds at a DGH in the West Midlands over a 12-month period from August 2012 onwards. We recorded the date of their first variceal bleed (index bleed) and the scheduled follow up endoscopy procedure. We also recorded any adverse events such as rebleeds (bleeds in &lt;7 days since the index bleed) or interval bleeds (bleeds that occurred &gt;7 days post index bleed). <h3>Results</h3> 31 patients identified during 12 month period had total 45 acute variceal bleeds, requiring urgent endoscopy. Haemostasis was achieved in all but one occasion 97.8% (44/45), with the majority (32) receiving band ligation and remaining receiving sclerotherapy or combination of therapies. 20% of total bleeds had rebleeds or died within 7 days. Of the remaining 36 bleeds, 14% had scheduled repeat endoscopy in &lt;7 days as per last BSG guidelines, 29% had scheduled endoscopy between 1–8 weeks, which conforms to the standards suggested in new ASGE guideline, 20% had follow up endoscopy after 8 weeks, and 37% had no follow up endoscopy. The mortality rates of the people rescoped within 0–2 weeks and 2–8 weeks were 78% and 23% respectively with multiple reasons contributing. <h3>Conclusion</h3> There is inconsistency in the duration to follow up endoscopy practice perhaps due to wide discrepancy in available guidance and patient compliance. It is likely that in real life practice in UK, rescoping interval is variable and inconsistent. It would be helpful to reassess current BSG guidelines and consider follow up endoscopy within 3–8 weeks after an index variceal bleed, with ongoing prospective review and audit to inform future adjustment. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Fortune and Garcia-Tasao, 2014 Bosch and Berzigotti, 2008 Gastroenterol Endosc. 2014;80(2) Gut, 2000;46(S3) Hepatology 2007;6(3) Harewood, Baron and Song, 2006 Ishaq S. Gastrointest Endosc. 2015, in press
Abstract O-3: A β1-Adrenergic Receptor/β-Arrestin1-Regulatable MicroRNA, MiR-150 Protects the Mouse Heart from Ischemic Injury by Repressing Pro-apoptotic Egr2 and P2x7r
Authors: Il-man Kim, Yaoping Tang, Yongchao Wang, Kyoung-mi Park, Qiuping Hu
Journal: Circulation Research (2014)

MicroRNA (miR)-150 is down-regulated in patients with acute myocardial infarction (AMI), atrial fibrillation, dilated and ischemic cardiomyopathy as well as in various mouse heart failure (HF) models. Circulating miR-150 has been recently proposed as a better biomarker of HF than clinically used markers such as brain natriuretic peptide. We recently showed that β-arrestin1-biased β1-adrenergic receptor (β1AR) cardioprotective signaling activated by the β-arrestin-biased β-blocker, carvedilol (Carv) stimulates the processing of miR-150 in the heart (see figure A). However, the potential role of miR-150 in ischemic injury and HF is unknown. Here, we show that genetic deletion of miR-150 in mice causes abnormalities in cardiac structural and functional remodeling after MI. The cardioprotective roles of miR-150 during ischemic injury were attributed to repression of the pro-apoptotic genes egr2 (zinc binding transcription factor induced by ischemia) and p2x7r (pro-inflammatory ATP receptor) [see figure B]. These findings reveal a pivotal role for miR-150 as a regulator of cardiomyocyte survival during cardiac injury. In conclusion, our study will help to stratify HF patients that may respond better to β-arrestin-biased β-blockers, which is guided by circulating levels of miR-150.

   ![][1]  [1]: /embed/graphic-1.gif
US spent more on mental illness than on any other conditions in 2013, study finds
Authors: Michael McCarthy
Journal: BMJ (2016)

In 2013 the United States spent $201bn (£138bn; €179bn) on mental health disorders, more than on any other groups of conditions, a study has found.1 More than 40% of the spending was for the care of institutionalized groups, which included nursing home residents, long term patients in psychiatric hospitals, and prisoners.

The next four most expensive conditions in 2013 were heart conditions, which cost $147bn, trauma ($143bn), cancer ($95bn), and pulmonary conditions ($95bn). After these were osteoarthritis, normal birth, diabetes, kidney disease, and hypertension.

Overall, healthcare spending grew at an average annual rate of 5.9% between 1996 and 2013, outstripping the growth of gross domestic product (GDP), which grew at …
Outbreaks Associated With Environmental and Undetermined Water Exposures — United States, 2011–2012
Authors: Karlyn D. Beer, Julia W. Gargano, Virginia A. Roberts, Hannah E. Reses, Vincent R. Hill, Laurel E. Garrison, Preeta K. Kutty, Elizabeth D. Hilborn, Timothy J. Wade, Kathleen E. Fullerton, Jonathan S. Yoder
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Exposures to contaminated water can lead to waterborne disease outbreaks associated with various sources, including many that are classified and reported separately as drinking water or recreational water. Waterborne disease outbreaks can also involve a variety of other exposures (e.g., consuming water directly from backcountry or wilderness streams, or inhaling aerosols from cooling towers and ornamental fountains). Additionally, outbreaks might be epidemiologically linked to multiple water sources or may not have a specific water source implicated.
Association of Atrial Fibrillation and Cancer
Authors: Faisal Rahman, Darae Ko, Emelia J. Benjamin
Journal: JAMA Cardiology (2016)

David Conen, MD, MPH; Jorge A. Wong, MD, MPH; Roopinder K. Sandhu, MD, MPH; Nancy R. Cook, ScD; I-Min Lee, MD, ScD; Julie E. Buring, ScD; Christine M. Albert, MD, MPH
Folic Acid
Authors: John L. Zeller, Alison E. Burke, Richard M. Glass
Journal: JAMA (2006)

Folic AcidF olic acid (also called folate) is one of the B vitamins (substances essential in very small quantities for nutrition).Leafy vegetables such as spinach and turnip greens, dried beans and peas, avocados, bananas, oranges, and asparagus provide us with natural sources for this vitamin.Folate is essential for the body.It is involved in the synthesis, repair, and normal functioning of DNA (deoxyribonucleic acid-the molecular basis for heredity).Folate is necessary for the production and maintenance of new cells.This is especially important during periods of rapid cell division and growth that occurs during pregnancy and in the development of young children.The December 13, 2006, issue of JAMA includes an article on folate supplementation and its effect on risk of cardiovascular diseases.
Elevation of RBC glycine and choline levels in geriatric patients treated with lithium
Authors: N Pomara, M Banay-Schwartz, R Block, M Stanley, S Gershon
Journal: American Journal of Psychiatry (1983)

During 6 weeks of lithium treatment, the RBC glycine and choline levels of five cognitively impaired geriatric subjects without affective disorders increased significantly and correlated with RBC and plasma lithium levels. The subjects' cognitive processes did not improve.
Abstract P1-06-05: The impact of ethnicity on normal breast biology
Authors: H Nakshatri, M Anjanappa, P Bhat-Nakshatri
Journal: Cancer Research (2016)

Abstract The incidence of/mortality from the most aggressive triple negative breast cancer (TNBC) is higher in African American- (AA) than Caucasian (CA)-women. In contrast, breast cancer in Hispanic-women is generally less aggressive. There is an ongoing debate as to whether AA-women have an increased incidence of TNBCs that have poor outcome or there are unique biological factors in AA-women that promote aggressive biology. Through unique approaches, we provide evidence for distinct biology in the normal breasts of CA-women, AA-women, and Hispanic-women. Using resources from the Komen Normal Tissue Bank and a primary cell culturing system that enabled propagation of normal epithelial cells of different lineages including mature-luminal, luminal-progenitor, and stem cells from different ethnic groups, we have identified a subpopulation of CD44high/CD24- cells that are unique to AA-women (p=0.0001). This AA-women-specific subpopulation expressed higher levels of Collagen 3A1, Collagen 5A2, CTNNB1 (β-Catenin of Wnt), FOXC2, and ZEB1 compared to common CD44+/CD24+ subpopulation in every breast. Gene expression pattern in the AA-specific CD44high/CD24- population showed marked similarity to gene expression pattern in the recently described PROCR+ multi-potent mammary stem cells. Indeed, the breast epithelial cells of AA-women were enriched for PROCR-positive stem cells compared to CA-women or Hispanic-women (p=0.015). In contrast to cells from CA- and AA-women, cells isolated from the healthy breast of Hispanic-women displayed mostly differentiated features as they were enriched for CD49f-/EpCAM+ and CD271-/EpCAM+ mature cells. Cells from CA-women, AA-women and Hispanic-women are currently being immortalized to determine the cell types that are preferentially immortalized in each of these ethnic groups. These results suggest ethnicity-dependent differences in Wnt, extracellular matrix, and epithelial to mesenchymal transition (EMT) signaling in normal breast epithelial cells and differences in the proportion of cells that are susceptible to immortalization/transformation. This work is supported by Susan G. Komen for the Cure to HN (SAC110025). Citation Format: Nakshatri H, Anjanappa M, Bhat-Nakshatri P. The impact of ethnicity on normal breast biology. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-06-05.
Abstract P3-05-09: Exploring bazedoxifene and palbociclib as potential therapeutic strategies for overcoming ESR1-mediated endocrine resistance
Authors: M Nguyen, G Buchwalter, F Luo, L Garraway, M Brown, R Jeselsohn
Journal: Cancer Research (2016)

Abstract INTRODUCTION Despite effective endocrine treatments, endocrine resistance remains a major clinical challenge. We and other groups have recently detected ligand-binding domain ESR1 mutations in metastatic estrogen receptor positive ( ER+) breast cancers. Our preclinical studies showed that these mutations confer constitutive activity and relative resistance to tamoxifen and fulvestrant. In this study we sought to investigate therapeutic strategies to overcome resistance rendered by the ESR1 mutations. Since our previous studies showed relative resistance to tamoxifen or fulvestrant, we hypothesized that bazedoxifene, a high affinity third generation SERM/SERD could overcome resistance driven by the ER mutant resistance. Additionally, we hypothesized that inhibiting cyclin D1, a key ER transcriptional target gene and cell cycle regulator, is a second potential therapeutic strategy to circumvent resistance rendered by mutant ER. Therefore in this study we tested the effects of bazedoxifene, palbciclib and their combination on cell proliferation in the presence and absence of the ESR1 mutations. METHODS For this study we established doxycycline inducible MCF7 cell lines expressing the ER-LBD mutations (Y537S, Y537N and D538G) and WT-ER as control. Cell proliferation response to bazedoxifene, tamoxifen, fulvestrant, palbociclib and the bazedoxifene-palbociclib combination was evaluated. RESULTS Cells harboring mutant ER were relatively resistant to tamoxifen and fulvestrant, as expected, and remained sensitive to single agent bazedoxifene and palbociclib. The combination of bazedoxifene and palbociclib was found to be superior to the single agents and exhibits synergistic activity. CONCLUSION The combination of bazedoxifene and palbociclib inhibits mutant ER cell growth and other cell models of endocrine resistance and is a potential therapeutic combination. Citation Format: Nguyen M, Buchwalter G, Luo F, Garraway L, Brown M, Jeselsohn R. Exploring bazedoxifene and palbociclib as potential therapeutic strategies for overcoming ESR1-mediated endocrine resistance. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-05-09.
Dengue type 3 virus infections in European travellers returning from the Comoros and Zanzibar, February-April 2010
Authors: P Gautret, F Simon, H Hervius Askling, O Bouchaud, I Leparc-Goffart, L Ninove, P Parola, Collective for EuroTravNet
Journal: Eurosurveillance (2010)

In late February-early April 2010, five cases of dengue fever were diagnosed in returning travellers in Europe in EurotravNet sites in Sweden and France in patients with travel history to the Comoros and/or Zanzibar, Tanzania. Four cases were non-complicated dengue fever and one case dengue hemorrhagic fever. Three patients were viraemic at the time of diagnosis and infected with Dengue type 3 virus.
Versatile Nanosystem-Based Cancer Theranostics: Design Inspiration and Predetermined Routing
Authors: Yaw Opoku-Damoah, Ruoning Wang, Jianping Zhou, Yang Ding
Journal: Theranostics (2016)

The relevance of personalized medicine, aimed at a more individualized drug therapy, has inspired research into nano-based concerted diagnosis and therapeutics (theranostics). As the intention is to "kill two birds with one stone", scientists have already described the emerging concept as a treasured tailor for the future of cancer therapy, wherein the main idea is to design "smart" nanosystems to concurrently discharge both therapeutic and diagnostic roles. These nanosystems are expected to offer a relatively clearer view of the ingenious cellular trafficking pathway, in-situ diagnosis, and therapeutic efficacy. We herein present a detailed review of versatile nanosystems, with prominent examples of recently developed intelligent delivery strategies which have gained attention in the field of theranostics. These nanotheranostics include various mechanisms programmed in novel platforms to enable predetermined delivery of cargo to specific sites, as well as techniques to overcome the notable challenges involved in the efficacy of theranostics.