THE TREATMENT OF ACUTE BACTERIAL ENDOCARDITIS WITH PENICILLIN
Authors: F WILHELM, H L HIRSH
Journal: Annals of Internal Medicine (1947)

Article1 February 1947THE TREATMENT OF ACUTE BACTERIAL ENDOCARDITIS WITH PENICILLINFREDA WILHELM, M.D., HAROLD L. HIRSH, M.D., HUGH H. HUSSEY, M.D., F.A.C.P., HARRY F. DOWLING, M.D., F.A.C.P.FREDA WILHELM, M.D.Search for more papers by this author, HAROLD L. HIRSH, M.D.Search for more papers by this author, HUGH H. HUSSEY, M.D., F.A.C.P.Search for more papers by this author, HARRY F. DOWLING, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-26-2-221 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPrior to the use of penicillin, the establishment of a diagnosis of acute bacterial endocarditis was tantamount to prophesying the patient's death within one to six weeks. In the literature we have found reference to 40 patients with acute bacterial endocarditis who have been treated with penicillin (table 1).1, 12Among the 25 patients whose infection was caused by aStaphylococcus aureusall but five died. Four of the patients with pneumococcic endocarditis died and two recovered. Five of the seven patients with hemolytic streptococcic endocarditis died, whereas death was reported in the case of one patient with gonococcic endocarditis....Bibliography1. Case Records of the Massachusetts General Hospital (Case 29162), New Eng. Jr. Med., 1943, ccxxviii, 519. Google Scholar2. Case Records of the Massachusetts General Hospital (Case 29371), New Eng. Jr. Med., 1943, ccxxix, 481. Google Scholar3. KEEFERBLAKEMARSHALLLOCKWOODWOOD CSFGEKJSWB: Penicillin in the treatment of infections: statement by the Committee on Chemotherapeutic Agents, Division of Medical Sciences, National Research Council, Jr. Am. Med. Assoc., 1943, cxxii, 1217. CrossrefGoogle Scholar4. HERRELL WEa. : The rôle of penicillin in the treatment of bacterial infections, South. Med. Jr., 1944, xxxvii, 150. b. HERRELL W. E.: The clinical use of penicillin. An antibacterial agent of biologic origin, Jr. Am. Med. Assoc., 1944, cxxiv, 622. CrossrefGoogle Scholar5. DAWSONHOBBY MHGL: The clinical use of penicillin. Observations in 100 cases, Jr. Am. Med. Assoc., 1944, cxxiv, 611. CrossrefGoogle Scholar6. HARFORDMARTINHAGEMANWOOD CGSPPOWB: Treatment of staphylococcic, pneumococcic, gonococcic and other infections with penicillin, Jr. Am. Med. Assoc., 1945, cxxvii, 253, 325. CrossrefGoogle Scholar7. MEADSHARRISFINLAND MHWM: The treatment of bacterial endocarditis with penicillin. Experiences at the Boston City Hospital during 1944, New Eng. Jr. Med., 1945, ccxxxii, 463. CrossrefGoogle Scholar8. DOLPHINCRUICKSHANK AR: Penicillin therapy in acute bacterial endocarditis, Brit. Med. Jr., 1945, i, 897. CrossrefGoogle Scholar9. ANDERSON DG: Clinical observations on the treatment of various infections with penicillin, Bull. N. Y. Acad. Med., 1945, xxi, 581. Google Scholar10. GLASERSMITHHARFORDWOOD RJROCGWB: The treatment of bacterial endocarditis with penicillin, Jr. Lab. and Clin. Med., 1946, xxxi, 291. Google Scholar11. CATALDO RJ: Acute bacterial endocarditis; a case report with recovery after treatment with penicillin, Ann. Int. Med., 1946, xxiv, 485. Google Scholar12. FIRESTONE GM: Meningococcus endocarditis, Am. Jr. Med. Sci., 1946, ccxi, 556. CrossrefGoogle Scholar13. BLOOMFIELDHALPERN ALRN: The penicillin treatment of subacute bacterial endocarditis. Some problems, Jr. Am. Med. Assoc., 1945, cxxix, 1135. CrossrefGoogle Scholar14. HIRSHDOWLING HLHF: The treatment of Streptococcus viridans endocarditis with penicillin, South. Med. Jr., 1946, xxxix, 55. CrossrefGoogle Scholar15. HUSSEYKELIHERSCHAEFERWALSH HHTFBFBJ: Septicemia and bacterial endocarditis resulting from heroin addiction, Jr. Am. Med. Assoc., 1944, cxxvi, 535. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Washington, D.C.*Received for publication July 23, 1946.From the Georgetown and George Washington University Medical Divisions, Gallinger Municipal Hospital, and the Departments of Medicine, Georgetown University School of Medicine and George Washington University School of Medicine. 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