tbuckley/cabot-search huggingface dataset:
Abstract 19717: Patient Characteristics Associated with False Arrhythmia Alarms in Intensive Care
Authors: Patricia R Harris, Jessica K Zègre-Hemsey, Tina Mammone, Daniel Schindler, Xiao Hu, Yong Bai, Steven M Paul, Barbara J Drew
Journal: Circulation (2014)

Introduction: A high rate of false arrhythmia alarms leads to clinical alarm fatigue, i.e. desensitization and inappropriate silencing of alarms. Objective: To determine patient characteristics associated with frequent false arrhythmia alarms in the intensive care unit (ICU). Methods: This descriptive, observational study prospectively enrolled every consecutive patient admitted to 1 of 5 adult ICUs (77 beds) at an urban medical center during March 2013. All monitor alarms and continuous waveforms were automatically stored on a secure server. Expert nurse scientists used a standardized protocol to annotate 6 clinically important arrhythmia alarms (asystole, pause, ventricular fibrillation, ventricular tachycardia, accelerated ventricular rhythm, ventricular bradycardia) as true or false. Medical records were examined to acquire patient characteristic data. Results: A total of 461 unique patients (mean age=60) were enrolled, generating 2,507,822 alarms, including all levels of arrhythmia, parameter, and technical alarms. There were 48,404 hours of patient monitoring time, resulting in an overall alarm rate of 52 alarms/hour. Investigators annotated 12,674 arrhythmia alarms; 11,137 were determined to be false (88%); 250 patients generated at least 1 of the 6 annotated alarm types; 2 patients generated 6,930 alarms (55%). Monitoring time for each patient was measured and number of false alarms/hour calculated for the clinically important arrhythmia alarms (range 0 - 8 false alarms/hour). Patient characteristics were compared with false alarm rates using nonparametric statistics to minimize the influence of outliers. Significant associations included: older age, ≥ 60 years (p=0.005), confused mental status (p&lt;0.001), breathing with mechanical ventilation (p&lt;0.001), and wide QRS complex due to bundle branch block, BBB (p=0.006) or ventricular paced rhythm (p=0.001). Conclusion: Patients likely to trigger a higher number of false arrhythmia alarms are those with confused mental status, on mechanical ventilation, or who have a wide QRS complex due to BBB or pacing. Algorithm improvements need to focus on better noise reduction (motion artifact with confused state) and distinguishing BBB and paced rhythms from ventricular arrhythmias.
The efficacy and safety of the combination of anti-BRAF agent and MEK inhibitor in advanced melanoma patients with BRAF V600 mutation: A meta-analysis.
Authors: Changqing Xie, Basem Mourad Labib Mishriky, Phillip Chae, Prashanti Atluri
Journal: Journal of Clinical Oncology (2015)

e20006 Background: The combination of anti-BRAF agent and MEK inhibitor has been shown to improve outcomes for advanced melanoma patients with BRAF V600E mutation. A meta-analysis was performed to evaluate the efficacy and safety of the combination of anti-BRAF agent and MEK inhibitor in these patients. Methods: Eligible trials were phase II or phase III randomized controlled trials (RCTs) comparing the combination therapy with anti-BRAF agent alone in advanced melanoma with BRAF V600E mutation reporting progression-free survival (PFS) , overall survival (OS), objective response rates(ORR) and adverse effects. Results: Four trials with five comparisons comprising 1784 patients were eligible for inclusion. BRAF inhibitors were vemurafenib and dabrafenib; MEK inhibition were trametinib and cobimetinib. The combination therapy improved PFS [hazard ratios (HR) 0.56; 95% confidence interval (CI) 0.47–0.68], OS (HR0.69; 95% CI 0.57–0.82], and ORR [relative risk (RR) 1.31; 95% CI 1.17–1.47]. There was no significant difference regarding overall grade 3 or higher adverse effects between them (RR 1.00; 95% CI 0.86-1.17). However, the risk of developing cutaneous squamous cell carcinoma and keratoacanthoma was significantly decreased about 80% in the combination arm (RR 0.19; 95% CI 0.10-0.36). Conclusions: Our meta-analysis suggests the benefit of combination therapy of anti-BRAF agent and MEK inhibitor for advanced melanoma patients with BRAF V600E mutation as first-line treatment, as well as decreased risk of developing cutaneous squamous cell carcinoma and keratoacanthoma. Trials in our meta-analysis differed in terms of anti-BRAF agents and MEK inhibitors, yet delivered comparable outcomes.
Spectrin Nice (beta 220/216): a shortened beta-chain variant associated with an increase of the alpha I/74 fragment in a case of elliptocytosis
Authors: B Pothier, L Morle, N Alloisio, MT Ducluzeau, C Caldani, C Feo, M Garbarz, I Chaveroche, D Dhermy, MC Lecomte
Journal: Blood (1987)
AB0661 Significance and Timing of Imaging in Takayasu's Arteritis: Table 1.
Authors: B. Kelesoglu, O. Karadag, U. Kalyoncu, L. Kilic, A. Erden, A. Akdogan, T. Hazirolan, S.A. Bilgen, I. Ertenli, S. Kiraz
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Conventional angiography is the diagnostic imaging criteria in 1990 ACR Takayasu Arteritis (TA) Classification Criteria. In recent years, non-invasive imaging methods such as Doppler Ultrasonography (Doppler US), Computerized Tomography Angiography (CT-Ang) and Magnetic Resonance Angiography (MR-Ang) are frequently used in diagnosis and/or follow up in TA. However, studies investigating optimal timing of follow up imaging are rare.<sup>1</sup> <h3>Objectives</h3> This study is aimed to investigate the radiologic changes in vessel involvements of TA patients approximately 1-year after diagnosis. <h3>Methods</h3> Database of our Vasculitis Center is retrospectively analyzed and 97 (Female/Male: 90/7) TA patients were included into the study. Demographic, clinical, radiological and therapeutic findings of patients were recorded. Patients with the same imaging method after one year of diagnosis were recruited into the further analysis. Radiological changes in the involved vessels were investigated (Doppler US, CT-Ang, MR-Ang). The effect of different immunosuppressive agents on vessel involvement changes were also studied. <h3>Results</h3> Mean ages and disease duration of patients were 43.0 (14.4) and 9.0 (5.1) years, respectively. Subclavian arteries and common carotid arteries were the most frequent involved vessels. All patients were on corticosteroid therapy and additional immunosuppressive agent. Most frequent initial immunosuppressive agents were methotrexate (n=35), cyclophosphamide (n=33), and azathioprine (n=20). Totally 13 (13.4%) patients had been treated with biologic therapies during all follow up. Fifty patients had a follow-up imaging with the same modality at 12±3 months. Sixty-eight percent of patients had stabile vessel involvements whereas 28% had progression and 4% had regression. No difference was found in radiological changes regarding patients with usage of different immunosuppressive agents (p=0.634). Table 1 shows the comparison of the diagnostic accuracy, coefficient of agreement and AUC results of 4 criteria. <h3>Conclusions</h3> Follow-up imaging modalities were investigated in a larger TA patient group than previous studies.<sup>1</sup> Almost 30% of TA patients in our Vasculitis center had progression in follow up imaging. This finding was concordant with previous literature. A follow up imaging at around 1-year of treatment, seems feasible in management of TA patients. <h3>References</h3> Mavrogeni S et al. The role of multimodalityimaging in the Evaluation of TakayasuArteritis. Sem ArthRheum 2013;42:401-412. <h3>Disclosure of Interest</h3> None declared
IMMUNOHISTOCHEMICAL ANALYSIS OF LYMPHOID AND MACROPHAGE CELL SUBSETS AND THEIR IMMUNOLOGIC ACTIVATION MARKERS IN TEMPORAL ARTERITIS: Influence of Corticosteroid Treatment
Authors: Maria Cinta Cid, Elias Campo, Guadalupe Ercilla, Antonio Palacin, Jaume Vilaseca, Jaume Villalta, Miguel Ingelmo
Journal: Arthritis & Rheumatology (1989)

To determine the phenotype of infiltrating mononuclear cells in patients with temporal arteritis (TA), we performed immunohistochemical studies on temporal artery biopsy specimens from 24 patients with biopsyproven TA. Interdigitating reticulum cells (IRC) were observed in 41% of the patients; disease duration was significantly shorter in these patients than in patients lacking IRC (mean 1.5 months versus 3.8 months). Infiltrating cells consisted predominantly of HLA–DR–expressing macrophages and T lymphocytes, especially of the CD4 subset. There were few B cells and no K cells. No relationship between cellular distribution and disease duration or treatment was found. Interleukin‐2 receptor expression was observed in 87.5% of biopsy specimens obtained prior to or within the first 4 days of treatment with prednisone, but in only 14% of specimens obtained later. The presence of IRC in patients with TA suggests an autoimmune reaction directed against an antigenic substance that resides in the arterial wall and is presented and processed in situ. DR‐expressing macrophages activated by CD4+ T lymphocytes may contribute to arterial damage in TA. Corticosteroids do not modify cellular distribution but induce important functional changes, as demonstrated by the disappearance of interleukin‐2 receptor expression in patients treated for more than 4 days.
Emotional and Other Selected Characteristics of Cigarette Smokers and Nonsmokers as Related to Epidemiological Studies of Lung Cancer and Other Diseases&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Abraham M. Lilienfeld, M.D., M.P.H.
Journal: JNCI Journal of the National Cancer Institute (1959)

In 1956 a probability sample of the adult populations of Buffalo, New York, was interviewed to determine whether cigarette smokers differed from nonsmokers with respect to emotional status and other selected characteristics. From this sample, groups of cigarette smokers and nonsmokers were matched by age, sex, race, and social class. This comparison indicated that smokers differ from nonsmokers in their replies to questions concerning emotional status. Cigarette smokers marry more often, move more frequently, change jobs more often, are hospitalized more often, and participate in more sports than nonsmokers. Also, the parents of nonsmokers are more often foreign born than those of smokers. No differences were noted in birthplace, religion, education, present marital status, and proportion of lifetime spent in large cities. Possible interpretations of these results are discussed, emphasizing their bearing on the statistical association of cigarette smoking with lung cancer and other diseases. In the characteristics studied, the degree of difference between smokers and nonsmokers was not sufficient to account for the high degree of association between cigarette smoking and lung cancer and therefore could not influence the causal inference derived from this association, though it might be sufficient to explain the association of cigarette smoking with peptic ulcer and coronary artery disease. Further studies are needed to test these possibilities.
PTU-110 What impact do hcv infection and subclinical cryoglobulinaemia have on the b cell repertoire?
Authors: R Swann, R Bashford-Rogers, M Robinson, PR Mills, S Barclay, J McLauchlan, P Kellam, A Patel
Journal: Gut (2015)

<h3>Introduction</h3> In addition to causing liver injury, hepatitis C virus (HCV) is closely associated with clonal B-cell pathologies such as cryogloglobulinaemia.<sup>1</sup>The virus is also capable of evading control by antibody responses.<sup>2</sup>Understanding the mechanisms by which HCV resists clearance by the adaptive immune system is important in vaccine design. We hypothesised that HCV infection may restrict the B-cell repertoire, predisposing to clonal B-cell disorders and contributing to impaired ability to mount an effective anti-viral antibody response. We aimed to explore this by determining: Any differences in B-cell Receptor (BCR) characteristics between HCV-infected individuals with and without cryoglobulinaemia. Any functional differences in viral neutralising ability associated with subclinical cryoglobulinaemia. <h3>Method</h3> Patients chronically infected with either genotype 1 (G1) or genotype 3 (G3) HCV were prospectively recruited in addition to healthy controls (HC). None had a prior diagnosis of cryoglobulinaemia. Patient serum was tested for presence of cryoprecipitates. Purified IgG from patient serum was tested for ability to prevent infection of cultured cells by a panel of HCV envelope-coated ‘pseudoparticles’. For a subset of HCV-infected patients and HC, RNA was extracted from PBMCs and cDNA libraries generated. BCR genes were amplified and underwent 454 sequencing. Sequences were analysed for overall diversity, clonality and specific gene usage using an in-house programme. <h3>Results</h3> 75 HCV-infected patients (36 G1, 39 G3) were recruited. Of the HCV-infected individuals, 28% (21/75) had detectable cryoprecipitates. There was no association between presence of cryoglobulins and functional antibody responses (p = 0.77). BCR sequences were analysed for 6 cryoglobulin positive, 6 cryoglobulin negative and 6 HC. There was no difference in overall BCR diversity between the groups. Cryoglobulin positive individuals showed reduced expression of IGHV 1–8 (p = 0.004). The antigen binding CDR3 region was longer in cryoglobulinaemic individuals than HC (p = 0.028). <h3>Conclusion</h3> Our data suggest that asymptomatic cyoglobulinaemic antibodies are common in chronic HCV infection. While these are not associated with an obvious deficit in antibody function or BCR diversity, next generation sequencing has revealed potentially important differences in their B-cell receptor populations. These novel findings and their functional implications require further analysis. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Charles ED, <i>et al</i>. Blood 2008;111:1344–1356 Edwards VC, <i>et al</i>. J Gen Virol. 2012;93:1–19
PTU-207 Outcome of anal cancer multidisciplinary team audit in a tertiary treatment centre
Authors: S Body, F Di Fabio, H Chave, P Nichols, G Branagan, K Nugent
Journal: Gut (2015)

<h3>Introduction</h3> Indications for anal cancer surgery for squamous cell carcinoma (SCC) are limited to selected early tumours and local treatment failure after radical chemoradiotherapy. The aim is to be able to offer Salvage surgery in at least 60% in patients with local relapse. This study reviewed our centre’s results and compared them with the national audit standards for outcomes of anal cancer in patients undergoing chemoradiotherapy after discussion the multidisciplinary team (MDT). <h3>Method</h3> Patients with anal SCC discussed at the Wessex anal cancer MDT meetings between 2010 and 2013 were retrospectively reviewed. Outcome measures were: proportion of salvage surgery offered, local control achieved, five-year post-salvage survival, delayed healing with plastic reconstruction and major (non-wound) morbidity – Clavien-Dindo ≥ 3. These were compared with the standards outlined by the Association of Coloproctology of Great Britain and Ireland. <h3>Results</h3> A total of 126 patients were discussed at the MDT. Ninety-six patients had anal SCC. Of these, 66 patients underwent radical chemoradiotherapy with Mitomycin C and 5-Fluorouracil or Capecitabine. Fourteen (22%) patients developed local recurrence. Of these, 9 (64%) had salvage surgery and plastic reconstruction with a Vertical Rectus Abdominis Myocutaneous (VRAM) flap. The five-year overall survival of patients who had radical chemoradiotherapy was 92% with a median follow-up of 27 months and 89% for patients who had salvage surgery with a median follow up of 32 months (p = 0.60, log rank test). In patients having surgery, delayed healing with plastic reconstruction was 11% and major (non-wound) morbidity -Clavien-Dindo ≥ 3 was 22%. <h3>Conclusion</h3> Long-term survival after radical chemoradiotherapy was achieved in the vast majority of patients even after salvage surgery and audit standards were fully met. <h3>Disclosure of interest</h3> None Declared.
THU0598 Course and Predictors of Pain and Physical Functioning in Patients with HIP Osteoarthritis: Systematic Review
Authors: M. de Rooij, M. van der Leeden, M.W. Heymans, J. Holla, A. Häkkinen, W.F. Lems, L.D. Roorda, C. Veenhof, D.C. Sanchez-Ramirez, H.C. de Vet, J. Dekker
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Knowledge of risk factors of future pain and physical functioning can be used to inform patients with hip osteoarthritis (OA) on the likely course of their condition and to adapt treatment according to the prognosis. <h3>Objectives</h3> To systematically summarise the literature on (1) the course of pain and physical functioning and on (2) prognostic factors of future pain and physical functioning in patients with OA of the hip. <h3>Methods</h3> A search was conducted in PubMed, CINAHL, Embase, Psych-INFO, and SPORTDiscus up to January 2014. Relevant study characteristics were reviewed. Studies were scored for their quality and a qualitative data synthesis was performed. <h3>Results</h3> Of the twelve included studies, seven were of high quality. No evidence was found on the course of hip pain, due to a lack of high quality studies. Because of high heterogeneity within studies (reflected by large standard deviations of change scores), the course of physical functioning was interpreted to be indistinct. Clinical characteristics (additional presence of knee OA and higher morbidity count), health behavior factors (no supervised exercise and a lower level of physical activity) and other patient characteristics (lower level of education) (weak evidence) were found to predict future pain (weak evidence). Higher morbidity count and lower vitality were found to predict deterioration in physical functioning (strong evidence). <h3>Conclusions</h3> The course of physical functioning was found to be highly variable. Several clinical characteristics, health and psychosocial factors prognosticate deterioration of pain and physical functioning in patients with hip OA. These findings may guide future research that aims to identify prognostically homogeneous subgroups of hip OA patients. To our knowledge, this is the first systematic review on prognostic factors for deterioration of pain and physical functioning in patients with hip OA. <h3>Disclosure of Interest</h3> None declared
Focal 99mTc-DMSA Uptake in Lung Parenchyma Without Structural Alterations on SPECT/CT
Authors: Gül Nihal Nursal, Mehmet Reyhan, Ali Fuat Yapar
Journal: Clinical Nuclear Medicine (2015)

Static renal scintigraphy with Tc-DMSA is commonly used for the evaluation of renal morphology and function. Extrarenal uptake of Tc-DMSA is a rare finding described previously on sites such as bone metastasis, hemangioma, and splenic amyloidosis. We report a case with Tc-DMSA activity in the lungs.
Lithium in aggressive behavior
Authors: H B Schiff, T D Sabin, A Geller, L Alexander, V Mark
Journal: American Journal of Psychiatry (1982)

A patient with intractable aggression was treated with lithium carbonate. On the basis of the authors' study and their review of the literature, they conclude that lithium may exacerbate the interictal aggression sometimes noted in patients with temporal lobe spike activity.
EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1
Authors: Ying Zhang, Shuling Wang, Lingsong Li
Journal: Cancer Research (2016)

EF hand (EFh) domain-containing proteins have been implicated in malignant progression, but their precise functional contributions are uncertain. Here, we report evidence that the EFh protein IBA2 promotes the proliferation of breast cancer cells by facilitating their transit through the G1-S cell-cycle transition. Mechanistic investigations revealed that IBA2 acted at the transcriptional level to promote the expression of the critical cell-cycle regulator cyclin D1. Clinically, we found that levels of IBA2 were significantly upregulated in breast cancer specimens, where its expression correlated positively with histologic grade. Our results suggest a key role for IBA2 in mammary tumorigenesis. Cancer Res; 76(15); 4535-45. ©2016 AACR.
Psychiatrists' transition from training to career: stress and mastery
Authors: J G Looney, R K Harding, M J Blotcky, F D Barnhart
Journal: American Journal of Psychiatry (1980)

Although the development of psychiatric residents has been studied extensively, continuing changes in psychiatrists after graduation from training have not. The authors present results of a survey research study of 263 psychiatrists recently graduated from a wide variety of training programs. The psychiatrists reported alarming symptoms of stress during this period, yet they used effective coping mechanisms and perceived themselves as increasing in growth, mastery, and confidence. Their overall contenment with their personal and professional lives effective coping mechanisms were those involving the establishment of support systems with loved ones.
SP0016 Revisiting Anti-CD28 Therapy
Authors: B. Vanhove
Journal: Annals of the Rheumatic Diseases (2015)

“CD28 blockade” has been long referred to as use of CTLA4-Ig. However it has now been recognized that CTLA4-Ig, which actually binds CD80/86, inhibits CD28-mediated costimulation as well as CTLA-4 and PDL-1 co-inhibitory signals that are important immune checkpoint inhibitors also involved in the control of Treg suppression. The development of non-agonist monovalent anti-CD28 antibodies made it possible to study the biological and therapeutic impacts of “selective CD28 blockade”. First, selective CD28 antagonists are able to differentially control effector and regulatory T cells. Second, they are very effective at blocking memory T cell responses, which in primates are under the dependency of CD28 and CTLA-4/PD-1. In vivo, selective CD28 antagonists have demonstrated efficacy in preclinical primate models of heart, kidney and bone marrow transplantation, as well as in autoimmune encephalomyelitis, skin inflammation and collagen arthritis models. A major finding drawn from these experiments is the possibility to induce an antigen-specific hyporesponsiveness, the mechanisms of which stays to be further defined. Selective CD28 antagonists have initiated their clinical development and might become a new therapeutic paradigm in autoimmunity and transplantation. <h3>Disclosure of Interest</h3> B. Vanhove Shareholder of: Shareholder of Effimune
Measles Vaccination
Authors: Jill Jin
Journal: JAMA (2015)

Measles VaccinationMeasles is a very contagious and serious disease.It is also very preventable.Measles is a viral illness that causes fever, rash, cough, runny nose, and reddened eyes.The vast majority of people who become ill with measles recover.But the virus can sometimes spread to the brain or lungs and cause severe illness or death.Babies, elderly people, and pregnant women have a higher risk of becoming severely ill from measles.Measles is no longer naturally present (endemic) in the United States.But it can be brought into the country when people who are not vaccinated travel to and from other countries.The measles virus very easily spreads through the air through coughing and sneezing.Because the virus is so contagious, if there are clusters of people who are not vaccinated, an outbreak can easily occur.
Host factors in breast cancer recurrence.
Authors: H W Daniell
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.11.1817 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1403063 Host factors in breast cancer recurrence. H W DaniellxH W DaniellSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.11.1817 PDF "Host factors in breast cancer recurrence.." Journal of Clinical Oncology, 10(11), pp. 1817–1819© 1992 by American Society of Clinical Oncology