tbuckley/cabot-search huggingface dataset:
A calibrated, small-caliber tip, transparent hood to aid endoscopic balloon dilation of intestinal strictures in Crohn’s disease: successful use of prototype
Authors: Yoshikazu Hayashi, Hironori Yamamoto, Tomonori Yano, Aya Kitamura, Takahito Takezawa, Yuji Ino, Hirotsugu Sakamoto, Yoshimasa Miura, Hakuei Shinhata, Hiroyuki Sato, Keijiro Sunada, Kentaro Sugano
Journal: Endoscopy (2013)

Endoscopic balloon dilation (EBD) has become a standard minimally-invasive therapy for Crohn's disease-related small-intestinal strictures [1]. However, the strictures are usually accompanied by inflammatory changes, which can hinder the passage of the balloon catheter through the strictures. Moreover, often several strictures are present that can require multiple consecutive dilations in a single procedure. Because accurate measurement of the stricture diameter is essential to the selection of the correct size of balloon catheter, we devised a prototype calibrated, small-caliber tip, transparent (CAST) hood to overcome this difficulty ([Fig. 1a]).
OP0243 Microrna Expression Profile in Patients with Spondyloarthritis- a Pilot Study
Authors: M. N. Magrey, T. Haqqi, A. Haseeb
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> microRNA (miRNA) expression pattern is believed to be reflective of underlying pathophysiologic processes and is specific to various disease states. At present there are no studies that have established a miRNA based signature profile in patients with axial Spondyloarthritis (SpA). We hypothesized that patients with axial SpA have aberrantly expressed circulating miRNAs reflective of underlying disease and inflammation and these dysregulated miRNAs can be detected through miRNA expression profiling. <h3>Objectives</h3> To determine the expression profile of miRNAs in plasma of patients with axial SpA and compare it with healthy, age and sex-matched controls. <h3>Methods</h3> 15 subjects with axial SpA based on the Assessment of Spondyloarthritis International Society (ASAS) classification criteria and 5 controls were recruited from our registry. Demographic data were collected and disease activity was measured using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). Peripheral blood samples (5 ml) were obtained from eligible consenting patients and controls. RNA from the plasma was prepared using miRNeasy kit (Qiagen) by a modified protocol. Expression of 175 miRNAs was screened in the plasma of all 15 patients and 5 controls using serum/plasma miRNA PCR arrays (Exiqon Inc. Woburn, MA) essentially following the manufacturer's instructions. Real-time PCR was carried out on StepOne Plus (Applied Biosystems) and the data was extracted and analyzed using ExiGen Enterprise software (MultiD, GöteborgSweden). Potential miRNA gene targets were identified using bioinformatics. Comparison between patients and controls was performed using 2 sample t Test. ESR and CRP levels were measured using standard laboratory methods. <h3>Results</h3> Of 19 patients; 60% were males, median age of 52 years (range 22-66) with mean BASDAI of 5.24. Mean level of ESR was 16.94 mm/hr and CRP was 0.74 mg/dl. 7 differentially expressed miRNAs (2 upregulated and 5 downregulated) (Table-1) were identified in plasma of patients SpA. miR-34a, associated with bone morphogenesus and growth was overexpressed and was predicted to target BMP-3 mRNA by Targetscan<i>S</i> and PicTar miRNA target algorithms. miR-150 was downregulated in all of the patient samples analyzed using the TaqMan Gene Expression assay. The most repressed miRNA was miR-16 and is predicted to regulate the expression of Activin A receptor (ACVR2B)-a receptor for growth and differentiation factor-5 (GDF-5). These dysregulated miRNAs may be contributing to the pathogenesis of SpA. <h3>Conclusions</h3> Patients with axial SpA, as compared to controls, have dysregulated expression of selected miRNAs in the plasma; and the differentially expressed miRNAs are predicted to target genes that play a role in bone morphogenesis, growth and immune response. <h3>Disclosure of Interest</h3> None Declared
A Multifactorial Intervention to Reduce the Risk of Falling among Elderly People Living in the Community
Authors: Mary E. Tinetti, Dorothy I. Baker, Gail McAvay, Elizabeth B. Claus, Patricia Garrett, Margaret Gottschalk, Marie L. Koch, Kathryn Trainor, Ralph I. Horwitz
Journal: New England Journal of Medicine (1994)

Since falling is associated with serious morbidity among elderly people, we investigated whether the risk of falling could be reduced by modifying known risk factors.
SP0161 The Khoala Knee And Hip Osteoarthritis Cohort
Authors: F. Guillemin
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> The Knee and Hip OsteoArthritis Long-term Assessment (KHOALA) cohort was set up during a French national multicenter prevalence survey in France. Subjects aged 40 to 75 years, with uni- or bilateral symptomatic hip and/or knee OA (ACR criteria), Kellgren and Lawrence (KL) stage 2 or greater, were recruited from 2007 to 2009, providing a representative sample of cases. Follow-up is ensured annually by mailed questionnaire or clinical visits. A total of 878 subjects were included, 222 with OA of the hip (mean age 61.2 years), 607 knee (mean age 62.0 years) and 49 both hip and knee (mean age 64.9 years). Major issues are quality of life outcomes assessed with generic (SF36) and specific (OAKHQOL) instruments. A biobank (blood and urine sample) was collected at baseline. Advantages of prevalent cases will be described, in terms of burden of disease assessment over time. Determinants of prognosis for functional and socio-economic outcomes will be investigated. This cohort of representative patients with knee and hip OA will be an opportunity for future collaborative research. <h3>Disclosure of Interest</h3> F. Guillemin Grant/research support from: Almirall, Expansciences, Genevrier, Genzyme, Grunenthal, Merck, Negma, Pierre Fabre, Pfizer, Sanofi
P257 Sub-optimal Inhaler Technique In Patients Aged Over 75 Years
Authors: S. Vandermolen, J. Berner, M. Almond, F. Huwez
Journal: Thorax (2014)

<h3>Introduction and objectives</h3> NICE guidelines highlight the importance of adequate inhaler technique to ensure sufficient drug delivery in asthma and C. O. P. D. Whilst adequate inhaler technique can be a problem for patients of any age, the delivery of inhaled medication continues to be a particular problem for elderly patients. Despite the existence of pressurised metered-dose inhalers and breath-actuated inhalers, physical and cognitive impairment continues to make the use of hand-held inhalers difficult in the elderly. It is therefore likely that inhaler use in the elderly is suboptimal, regardless of device used. <h3>Methods</h3> We assessed 50 consecutive patients aged over 75 years with C. O. P. D or asthma at our centre (mean age 78.24 ± 7.32). All had inhaler therapy prescribed prior to examination. Two observers assessed inhaler technique against guidelines adapted from the National Asthma Council of Australia<sup>1</sup> (see Table). Patients used either an Evohaler (pressurised metered-dose inhaler) or Accuhaler (breath-actuated inhaler) according to their choice. <h3>Results</h3> In the Evohaler group (25 patients), the average age was 78 (±5.5) with an average score of 6.6 (±1.81) / 10. In the Accuhaler group (25 patients), average age was 77 (±6.4) with an average score of 7.2 (±2.0) /10. ‘Crucial’ steps to adequate inhaler technique were also assessed.<sup>2</sup> The score in the Evohaler group was 4.4 (±1.2) /6, and in the Accuhaler group was 4.3 (±1.0) /6. <h3>Conclusion</h3> This study shows that despite the availability of both Evohaler (pressurised metered-dose inhaler) and Accuhaler (breath-actuated inhaler) effective use by the elderly is still sub-optimal. The very elderly need extra support when considering and prescribing inhalers. Whilst many centres have ‘good inhaler technique’ as a pillar of their COPD care bundle, it may be the case that specialist services, including the use of specialist devices, directed at the elderly may help to alleviate the problems of physical and cognitive impairment when using inhalers. <h3>References</h3> National Asthma Council Australia. Inhaler technique in adults with asthma or COPD. Melbourne: National Asthma Council Australia, 2008 Newman S. P. Inhaler treatment options in COPD. <i>Eur Respir Rev</i> 2005;14(96):102-108
Is there an epidemic of cancer?
Authors: W J Crisp, N Hayes, S A Raimes, S M Griffin
Journal: BMJ (1994)

EDITOR, - We welcome the attention brought by David Coggon and Hazel Inskip to the large increase in death rates from oesophageal cancer over the past 30 years.1 However, their conclusion on aetiological factors is flawed by relying on Office of Population Censuses and Surveys data, which fail to differentiate between the different histological types of oesophageal malignancy.2

It is widely accepted that smoking, and perhaps to a lesser extent, alcohol consumption, are important aetiological …
102nd Congress Adjourns; Session Included Cancer Issues
Authors: S. Bennett
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article 102nd Congress Adjourns; Session Included Cancer Issues Get access Sylvia Bennett Sylvia Bennett Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Pages 1475–1476, https://doi.org/10.1093/jnci/84.19.1475 Published: 07 October 1992
Pelvic Kidney Visualization on the Lymphoscintigraphy Images of a Patient With Uterine Cervix Cancer
Authors: Royasadat Alivifard, Zohreh Yousefi, Sima Kadkhodayan, Malihe Hasanzadeh, Ramin Sadeghi
Journal: Clinical Nuclear Medicine (2013)

We reported an unusual visualization of a pelvic kidney on the lymphoscintigraphy images of a patient with uterine cervix cancer, which was mistaken with para-aortic sentinel nodes. Delayed imaging clearly showed the nature of this activity. Our case underscores the importance of delayed pelvic lymphoscintigraphy imaging in the sentinel node mapping of gynecological cancers.
THU0040 Realtime Analysis of Monocyte Migration in 3D Synovial Micromass Tissue Cultures
Authors: R. Byrne, K. von Dalwigk, A. Hladik, G. Steiner, J. S. Smolen, H. Kiener, C. Scheinecker
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Monocytes (Mo) are among the first hematopoietic cells to migrate into the inflamed synovial tissue of arthritic joints. Monocyte migration appears to be associated with the expanding synovial lining network of fibroblast-like synovial cells (FLS). Whether cognitive interaction between Mo and FLS is required for an orchestrated migratory behavior has not been analyzed so far. <h3>Objectives</h3> We analyzed Mo migratory activity under inflammatory conditions in regard to cell-cell interactions with FLS. <h3>Methods</h3> Human FLS were prepared from synovial tissues obtained as discarded specimens following joint arthroplasty. CD14<sup>+</sup> Mo were isolated from peripheral blood by magnetic bead sorting. FLS and Mo were labeled with fluorescent membrane dyes and cultured in spherical extracellular matrix micromasses with an average size of 1.5 mm for up to two weeks. For stimulation experiments, micromasses were cultured in medium containing 10 ng/ml of tumor necrosis factor (TNF). At different time-points cell migration was monitored in individual micromasses by real-time confocal microscopy. <h3>Results</h3> Cell migration could be subdivided into three successive phases of cell movement. Phase I (day 1-3 of culture) was characterized by the formation of the synovial lining layer. Mo in close contact with FLS appeared sessile. On average 20% of Mo were in no apparent contact with FLS and displayed a mobile and seeking behavior. During phase II (day 3-7) already &gt;95% of Mo were in contact with FLS. The majority of Mo remained sessile whereas a fraction of Mo displayed a directed cell movement with an impressive maximum speed of up to 15 mcm/min. In addition the formation of Mo cell clusters was observed. The rapid Mo migration finally ceased during phase III (day 7-14). The addition of TNF i) increased the frequency and size of Mo cell clusters during phase II two and ii) prolonged the mobility of Mo into phase III. <h3>Conclusions</h3> The 3D synovial tissue culture system allows to monitor and analyzed subtle migration patterns of Mo in relation to the organized synovial lining architecture. Ongoing experiments address molecular mechanism(s) of Mo – FLS interaction in order to identify potential targets for future therapeutic intervention in arthritis. <h3>Disclosure of Interest</h3> None Declared
Pelvic Kidney Mimicking Recurrent Colon Cancer on FDG Positron Emission Tomographic Imaging
Authors: PEEYUSH BHARGAVA, HONGMING ZHUANG, MARC HICKESON, ABASS ALAVI
Journal: Clinical Nuclear Medicine (2002)

BHARGAVA, PEEYUSH M.D.; ZHUANG, HONGMING M.D., Ph.D.; HICKESON, MARC M.D.; ALAVI, ABASS M.D. Author Information
620 IS THE DIAGNOSIS OF IDIOPATHIC NON-CIRRHOTIC PORTAL HYPERTENSION BE CONSIDERED IN PATIENTS WITH PRIMARY ANTIBODY DEFICIENCIES?
Authors: I. Pentassuglio, F. Pulvirenti, E. Onori, S. Gioia, C. Pasquale, S. Nardelli, M. Merli, I. Quinti, O. Riggio
Journal: Journal of Hepatology (2013)
A randomized trial of cold-exposure on energy expenditure and supraclavicular brown adipose tissue volume in humans
Authors: Thobias Romu, Camilla Vavruch, Olof Dahlqvist-Leinhard, Joakim Tallberg, Nils Dahlström, Anders Persson, Mikael Heglind, Martin E. Lidell, Sven Enerbäck, Magnus Borga, Fredrik H. Nystrom
Journal: Metabolism (2016)

To study if repeated cold-exposure increases metabolic rate and/or brown adipose tissue (BAT) volume in humans when compared with avoiding to freeze.Randomized, open, parallel-group trial.Healthy non-selected participants were randomized to achieve cold-exposure 1hour/day, or to avoid any sense of feeling cold, for 6weeks. Metabolic rate (MR) was measured by indirect calorimetry before and after acute cold-exposure with cold vests and ingestion of cold water. The BAT volumes in the supraclavicular region were measured with magnetic resonance imaging (MRI).Twenty-eight participants were recruited, 12 were allocated to controls and 16 to cold-exposure. Two participants in the cold group dropped out and one was excluded. Both the non-stimulated and the cold-stimulated MR were lowered within the group randomized to avoid cold (MR at room temperature from 1841±199 kCal/24h to 1795±213 kCal/24h, p=0.047 cold-activated MR from 1900±150 kCal/24h to 1793±215 kCal/24h, p=0.028). There was a trend towards increased MR at room temperature following the intervention in the cold-group (p=0.052). The difference between MR changes by the interventions between groups was statistically significant (p=0.008 at room temperature, p=0.032 after cold-activation). In an on-treatment analysis after exclusion of two participants that reported ≥8days without cold-exposure, supraclavicular BAT volume had increased in the cold-exposure group (from 0.0175±0.015l to 0.0216±0.014l, p=0.049).We found evidence for plasticity in metabolic rate by avoiding to freeze compared with cold-exposure in a randomized setting in non-selected humans.
A MEDIUM TERM FOLLOW-UP BY MULTISLICE COMPUTED TOMOGRAPHY CORONARY ANGIOGRAPHY ASSESSING THE PERSISTENT PRESENCE OF BIORESORBABLE VASCULAR SCAFFOLD METALLIC RADIOPAQUE MARKERS AT THE SITE OF IMPLANTATION
Authors: Pannipa Suwannsom, Yoshinobu Onuma, Carlos Campos, Shimpei Nakatani, Yuki Ishibashi, Hiroki Tateishi, Maik Grundeken, Bojan Stanetic, Koen Nieman, Hans Jonker, Hector Garcia Garcia, Patrick W. Serruys
Journal: Journal of the American College of Cardiology (2015)
Herpetic Geometric Glossitis
Authors: S Lam, B L Lam
Journal: New England Journal of Medicine (1994)

Herpes simplex virus (HSV) infections in an immunocompromised host may be atypical in location and morphology. We describe five immunocompromised patients in whom HSV type 1 infection presented as linear fissures on the dorsum of the tongue. The tongue fissures were extremely tender and had a striking geometric pattern: longitudinal, crossed, or branched. The central well-papillated portion of the tongue was characteristically involved, usually without accompanying lesions of HSV infection on the lips, palate, or lateral edges of the tongue. The fissures healed between 3 and 12 days after treatment with acyclovir was begun. This experience suggests that linear or . . .
Case 40-1994
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Michael Hayes, E. Tessa Hedley-Whyte
Journal: New England Journal of Medicine (1994)

Presentation of CaseA 77-year-old woman was admitted to the hospital because of pain in the head and legs, fever, and sweats.The patient had been well until four weeks earlier, when she began to experience pain in the neck that extended over the lower third of the left side of the head and left mandible. The next morning she had an acute onset of “burning” in the lower legs, as if they were “on fire.” That night she changed her nightgown several times because of sweats. After several days of such symptoms the patient consulted a dentist; radiographs were . . .
CONTEXT OF VULNERABILITY OF GBM: DESCRIPTIVE GENOMICS LEADING TO EMPIRIC THERAPEUTICS
Authors: M. E. Berens, S. Kim, J. Kiefer, H. Dhruv, K. Vuori, B. Findlay, C. Hauser, R. Oshima, P. Alza-Blanc, D. Emig
Journal: Neuro-Oncology (2014)

BACKGROUND: The goal of genomics enabled medicine is to understand how specific molecular pathology of an individual tumor informs therapy tailored to specific vulnerabilities. Exploiting large datasets of human glioblastoma (GBM) and relevant, molecularly-profiled preclinical models enables an iterative learning-loop by which such profiling can produce hypotheses of effective, targeted treatment. Genomic, transcriptomic, and epigenomic profiling of glioblastoma enables depiction of driver-passenger relationships of molecular events among subgroupings of cases of the disease. The present study queries genomic profiles of GBM (TCGA) as well as a panel of patient-derived xenograft (PDX) models. Predictions of targets, and targeted drugs effective against those targets are tested empirically using short-term cultures of GBM PDX models. METHODS: Datamining of TCGA GBM combined with similar genomic profiling of a panel of orthotopic GBM PDX models establishes a data warehouse for discovery of subsets of the disease. These subsets, defined by driver-passenger relationships, partition GBM cases into discreet clusters, which enable follow-on bioinformatic queries for nodes of vulnerability. Short-term cultures of GBM PDX models afford testing cell proliferation, survival, migration, invasion, and differentiation responses to a collection of annotated chemical entities characterized as inhibition a wide spectrum of cancer-related targets (n = 600), establishing a “chemical biology fingerprint” of GBMs of distinct contexts. The chemical biology fingerprints can be mapped against the genomic profiling to find and prioritize candidate therapeutic targets matched to the molecular profile. RESULTS: Human GBM profiling bins tumors into molecular contexts based on driver-passenger relationships; GBM PDX models reside in the same or analogous contexts as primary tumor samples. Within such contexts, biochemical signaling and pathway functions portray associated distinct prioritized candidate targets, which align to varying degrees with Chemical Biology Fingerprints (CBFs). CONCLUSIONS: Multi-omics characterization of human GBM uncovers subclusters of the disease with distinct and unique chemovulnerabilities. Single- and multi-agent studies will afford matching effective interventions tailored to individual tumors. Supported by NIH NCI U01CA168397. SECONDARY CATEGORY: Tumor Biology.
Abstract P6-06-54: Analysis of treatment and survival of pathologic occult breast cancer with axillary lymph node metastasis: Nationwide retrospective study
Authors: G Sohn, BH Son, S Baek, S Lee, Y Lee, HJ Kim, BS Ko, J Yu, JW Lee, S-H Ahn
Journal: Cancer Research (2013)

Abstract Objective Occult breast cancer (OBC) is a rare presentation which accounts for 0.3-1.0% of all breast cancers. In spite of limited information, there is no consensus regarding the prognostic factors and treatment of OBC. This retrospective study intends to evaluate the overall survival and prognostic factors of occult breast cancer (OBC) in Korea. Method This study included 142 pathologic occult breast cancer patients from January 1990 to December 2009, identified from Korean Breast Cancer Society cancer registry. All patients had pathologically positive axillary lymph node (N1-N3) along with pathologically &amp; radiologically negative in-breast lesion (T0/Tx) based on retrospective review of database. Among 142 patients, 32 patients had only axillary lymph node dissection (ALND), 56 patients had breast conserving operation (BCO) with ALND and 54 patients had mastectomy with ALND. 96 patients (96%) had N1 disease, 23 patients (16.2%) had N2 disease and 23 patients (16.2%) had N3 disease. Results There was no significant statistical difference in overall survival among different operation method, which is ALND only, BCO with ALND, mastectomy with ALND (p = 0.061), considering that 12 patients (37.5%) among 32 patients who only had ALND had N3 disease comparing that only 7 (12.5%) out of 56 patients and 4 (7.4%) out of 54 patients had N3 disease in BCO with ALND and mastectomy with ALND group separately. Univariate analysis revealed that only nodal status was significant prognostic factor (p = 0.0004), and other factors including radiotherapy (p = 0.696), chemotherapy (p = 0.302), estrogen receptor positivity (p = 0.144), progesterone receptor positivity (p = 0.254), total number of removed lymph node (p = 0.586) didn't show statistical difference in overall survival. Conclusions This study suggests that OBC patients who only had ALND showed similar outcomes when comparing with patients who had BCO with ALND or mastectomy with ALND. Also only nodal status might be independent predictors for poor outcomes of occult breast cancer. Citation Information: Cancer Res 2013;73(24 Suppl): Abstract nr P6-06-54.
Pyomyositis Caused by Methicillin-Resistant<i>Staphylococcus aureus</i>
Authors: Maria E. Ruiz, Seife Yohannes, Christopher G. Wladyka
Journal: New England Journal of Medicine (2005)

To the Editor: Pyomyositis is common in tropical regions but is rarely reported in temperate climates. In the United States, most cases are associated with human immunodeficiency virus infection or other immunosuppressive conditions, including diabetes mellitus, cancer, connective-tissue diseases, and cirrhosis.1 Christin and Sarosi observed that Staphylococcus aureus was the causative organism in 70 percent of cases, and that 31 percent of the patients had bacteremia.2 We describe four patients with community-acquired pyomyositis caused by methicillin-resistant S. aureus who presented to our hospital within a span of six months. Patient 1 was a 22-year-old Nicaraguan woman without previous medical problems . . .