tbuckley/cabot-search huggingface dataset:
PWE-082 Audit of Barrett’s Oesophagus Surveillance in The London Cancer Alliance – Structured Programmes with Dedicated Lists/Databases Improve Prague Scoring and Appropriate Follow Up Intervals: Abstract PWE-082 Table 1
Authors: JM Dunn, P Wilson, S Chatu, C Collins, M Gess, JO Hayat, A Haycock, J Hoare, J Hunt, S Lean, L Pee, G Walker, S Zar, G Hanna
Journal: Gut (2016)

<h3>Introduction</h3> The London Cancer Alliance is a group of 17 hospitals in North West and South London serving an estimated catchment area of 5.7 million. We have previously demonstrated that dedicated Barrett's oesophagus (BE) surveillance lists improve dysplasia detection. LCA guidelines recommend dedicated surveillance lists, Prague reporting, dual pathology reporting of dysplasia and follow up intervals similar to national guidelines. <h3>Methods</h3> One month 'snap shot' audit of patients undergoing BE surveillance in June 2015. Structure of programme at each site was assessed with questionnaire. All patients undergoing endoscopy for BE were audited using endoscopy reporting software tools. New diagnoses or those referred with dysplasia for endotherapy were excluded. The Prague criteria, dysplasia detection rate and dual pathology reporting were assessed. Analysis was by independent t-tests for continuous variables and chi-squared tests for categorical variables. <h3>Results</h3> Responses were received from 13/17 sites. 6/13 ran dedicated surveillance lists and 5/6 had an active surveillance database. Dual pathology reporting for dysplasia was confirmed in 11/13 sites and BSG/LCA guidance adhered to in 12/13. A total of 137 patients underwent surveillance endoscopy. Results are shown in table 1. There was no difference in the mean number of procedures between sites with dedicated vs. non dedicated lists. Only 4/137 patients were diagnosed with dysplasia, with no significant difference between the 2 groups. Prague classification was significantly higher on dedicated lists (p &lt; 0.0001). There was a significant difference between appropriateness of follow up between centres with active surveillance database vs. those without (p = 0.008). <h3>Conclusion</h3> Approximately half the sites in the LCA have dedicated lists and/or active surveillance databases, with statistically significant higher Prague classification rates and appropriate choice of surveillance interval at follow up. These metrics could be adopted at a national level to assess quality of BE surveillance programmes. A larger national audit assessing utility of dedicated lists is warranted. <h3>Disclosure of Interest</h3> None Declared
Efficacy of Panobinostat (LBH589) in CTCL Cell Lines and a Murine Xenograft Model: Defining Molecular Pathways of Panobinostat Activity in CTCL.
Authors: Wenlin Shao, Joseph D. Growney, Yun Feng, Gregory O’Connor, Minying Pu, Yung-Mae Yao, Paul Kwon, Stephen Fawell, Peter Atadja
Journal: Blood (2007)
FRI0498 Clinical Characteristics of IGG4-Related Disease: A Retrospective Analysis of 166 Chinese Patients
Authors: K.-H. Yu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Since the initial recognition of autoimmune pancreatitis (AIP), elevated serum IgG4 levels and increased numbers of IgG4-positive plasma cells in tissues have been regarded as diagnostic hallmarks of the disorder. However, the role of the IgG4 level in other non-AIP IgG4-RD is unclear. <h3>Objectives</h3> To investigate the clinical features and factors associated with IgG4 test positivity over an 8-year period in 166 patients with IgG4-related diseases (IgG4-RD). <h3>Methods</h3> The medical records of 2,968 adult subjects who underwent serum IgG4 level tests conducted between December 2007 and August 2014 were reviewed. <h3>Results</h3> Among 2,968 patients, 166 (5.6%) were diagnosed with IgG4-RD and 2,802 (94.4%) were determined to have other diseases (non-IgG4-RD group). The mean IgG4 level in subjects with IgG4-RD was 1087.5 mg/dL (median: 597.0, range: 15–6790 mg/dL), which was significantly higher than that of subjects with non-IgG4-RD (mean: 104.1, median: 75.0, range: 1–4400 mg/dL; p&lt;0.0001). Among the 166 IgG4-RD patients, the mean age was 58.5 ± 15.9 years (range: 21–87). Of 166 patients with IgG4-RD, 87 (52.4%) had an IgG4-RD other than autoimmune pancreatitis (non-AIP IgG4-RD). Twenty-seven out of 166 IgG4-RD (16.3%) patients had other organ involvement (OOI) outside of the pancreatobiliary system. IgG4 levels were elevated (&gt;135 mg/dL) in 143 (86.1%) of 166 patients with IgG4-RD and in 652 (23.3%) of 2,802 patients with non-IgG4-RD (p&lt;0.001). The present study showed that the best IgG4 cutoff was 222 mg/dL for the diagnosis of IgG4-RD. <h3>Conclusions</h3> In the present study, we demonstrated that more than half of the diseases associated with IgG4-RD were non-AIP IgG4-RD. Among the 166 IgG4-RD patients, the manifestations covered the full range of organ system involvement. Moreover, the best IgG4 cutoff (measured with nephelometry using a Siemens BN ProSpec instrument and Siemens reagent) was 222 mg/dL for IgG4-RD. <h3>Disclosure of Interest</h3> None declared
ATG5 and ATG7 Fulfill Essential and Non-Redundant Roles in Human Hematopoietic Stem/Progenitor Cells
Authors: Hendrik Folkerts, Maria Catalina Gomez Puerto, Albertus T.J. Wierenga, Koen Schepers, Jan Jacob Schuringa, Paul J. Coffer, Edo Vellenga
Journal: Blood (2014)
Oridonin, An Ent-Kaurane Diterpenoid, Shows Antileukemic Effect and Enhances the Effect of Indarubicin on Human T-Cell Leukemia Cell Line
Authors: Kangni Wu, Yanmin Zhao, Haowen Xiao, Lifei Zhang, Lizhen Liu, Yingjia Wang, Xiaohong Yu, He Huang
Journal: Blood (2010)
Myeloid Cell Maturation Is Disrupted By Monosomy 7 or By Gain of Additional Genetic Aberrations during Clonal Evolution in Myelodysplastic Syndromes.
Authors: Barbara Katharina Zehentner, Jevon Cutler, Luise Hartmann, Krystal Johnson, Richard Bennington, Wayne Fritschle, Keely Ghirardelli, Lisa Broderson, Doug Chapman, Christine F Stephenson, Monica E de Baca, Timothy Singleton, Denise A. Wells, Michael R. Loken
Journal: Blood (2014)
AB0937 The Comparison of Synovial Degree Inflammation between Systemic Sclerosis and Rheumatoid Arthritis by Magnetic Resonance Imaging of Hands
Authors: B.N. Stamenkovic, A.M. Stankovic, J.M. Nedovic, S.K. Stojanovic, V. Zivkovic, S.B. Milenkovic, I. Aleksic, N. Damjanov
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> MRI is a usefull tool for assessing subclinical synovial inflammation and joint damage in rheumatic diseases. There are no references clarifying the problem of distinguishing arthritis in systemic sclerosis (SSc) and rheumatoid arthritis (RA) so far <h3>Objectives</h3> The aim of our investigation is to compare the degree of inflamatory changes of the hand (bone edema, synovitis, bone erosion and tenosynovitis) in SSc and RA. <h3>Methods</h3> 82 SSc pts, mean age 54,5y and 35 RA pts (EULAR/ACR 2010 criteria), mean age 54,3y underwent low field MRI with gadolinium at the dominant hand including wrist and MCP joints 2–5. Assessment of bone marrow edema, synovitis, bone erosions and tenosynovitis was performed by the OMERACT RA MRI scoring system. Images were evaluated independently by two blinded readers. The mean scores of the two readers were analyzed. <h3>Results</h3> Anti-citrullinated peptide antibodies (ACPA) and rheumatoid factor (RF) were found in 89% and 74,3% of RA pts and 13,4% and 14,6% of SSc pts. Synovitis was more frequently detected on MRI with significantly higher score in RA compared to SSc (wrist:4,37±1,31 vs 2,69±2,29,p&lt;0,001; MCP joints:5,26±2,09 vs 3,15±2,95, p&lt;0, 001). MRI erosion score in the wrist and MCP was significantly higher in RA compared to SSc (wrist:20,57±10,23 vs 6,58±10,89,p&lt;0,001; MCP joints:10,51±7,90 vs 3,99±9,82, p&lt;0,001). MRI bone edema score was also significantly higher in RA compared to SSc (wrist:18,60±5,01 vs 6,84±7,43, p&lt;0,001; MCP joints:9,09±4,27 vs 4,04±4,76, p&lt;0,001). <h3>Conclusions</h3> The present data suggest great frequency of inflammatory changes on the hands in SSc and RA using MRI. Inflammation scores were significantly higher in RA compared to SSc. MRI may be helpful in differentiating arthritis in RA and SSc, specially in subclinical inflammation. <h3>Disclosure of Interest</h3> None declared
Matching of MHC Class I Chain-Related Genes a and B Is Associated with Reduced Incidence of Severe Acute Graft-Versus-Host Disease after Unrelated Hematopoietic Stem Cell Transplantation
Authors: Raphael Carapito, Nicolas Jung, Meiggie Untrau, Sandra Michel, Angélique Pichot, Gaëlle Giacometti, Anne Cesbron, Katia Gagne, Machteld Oudshoorn, Ronnie van Der Holt, Myriam Labalette, Eric Spierings, Christophe Picard, Pascale Loiseau, Ryad Tamouza, Antoine Toubert, Daniel Hanau, Anne Parissiadis, Valerie Dubois, Nicole Raus, Xavier Lafarge, Luca Vago, Fabio Ciceri, Catherine Paillard, Sergio Querol, Jordi Sierra, Katharina Fleischhauer, Arnon Nagler, Miriam Hoffmann, Noël Milpied, Mauricette Michallet, Bruno Lioure, Régis Peffault de Latour, Myriam Labopin, Hidetoshi Inoko, Franz Claas, Didier Blaise, Ibrahim Yakoub-Agha, Philippe Moreau, Dominique Charron, Masao Ota, Mohamad Mohty, Gérard Socié, Seiamak Bahram
Journal: Blood (2014)
A family information brochure and dedicated website to improve the ICU experience for patients’ relatives: an Italian multicenter before-and-after study
Authors: Giovanni Mistraletti, Michele Umbrello, Elena Silvia Mantovani, Benedetta Moroni, Paolo Formenti, Paolo Spanu, Stefania Anania, Elisa Andrighi, Alessandra Di Carlo, Federica Martinetti, Irene Vecchi, Alessandra Palo, Cristina Pinna, Riccarda Russo, Silvia Francesconi, Federico Valdambrini, Enrica Ferretti, Giulio Radeschi, Edda Bosco, Paolo Malacarne, Gaetano Iapichino
Journal: Intensive Care Medicine (2016)
P102 The liverpool healthy lung project – seeking out early stage lung cancer
Authors: MJ Ledson, S Grundy, E Gaynor, R Arvanitis, M Timoney, J Field
Journal: Thorax (2016)

Liverpool has one of the highest respiratory morbidity rates in England, with double the lung cancer incidence, particularly in lower socioeconomic groups. To tackle this health inequality in February 2016 in conjunction with Liverpool CCG, the primary care sector, public health and Liverpool University we commenced the 3-year £3.3M Liverpool Healthy Lung Project. The project has 2 sequential phases. <h3>Phase 1</h3> By means of a series of coordinated focused public engagement events throughout the city, starting in areas with higher lung cancer incidence, this aims to promote positive messages around lung health, and address the fear and fatalism surrounding lung cancer. <h3>Phase 2</h3> All individuals between the ages of 58–70 who have COPD, have smoked, or are asbestos exposed are invited to a face to face lung health check conducted by an experienced respiratory nurse. Positive lifestyle messages are promoted and a 5-year personal lung cancer risk calculated (www.MyLungRisk.org using LLPv2 risk model). Those who trigger the 5% threshold are offered a low dose thoracic CT scan. The community healthy lung events attracted 1346 interactions and 462 individuals completed spirometry. 90 (19%) of these tests were abnormal which triggered a consultation in primary care. Projections suggest 34,000 patients will be eligible for phase 2: in the first 12 weeks, in Picton Ward (eligible population 2471) 896 (36%) individuals booked to attend the lung health check, where 230 (31%) triggered the offer of a CT. To date 138 scans have been reported: 24 (17%), had significant findings, of which 9 (6%) require a 3 month and 3 (2%) 12 month repeat scan for nodules. Two individuals had confirmed cancer (both resected), with 2 further cases currently being worked up. Of 406 patients (45%) without previously diagnosed COPD, 180 (44%) had abnormal spirometry, and have gone on to further diagnostics. The complete Picton Ward data will be presented at the conference. This innovative project is already improving access to respiratory healthcare in a deprived area of Liverpool, and should improve outcomes for lung cancer in this disadvantaged population. The project has been adopted by the national ACE program.
Allogeneic Hematopoietic Stem Cell Transplantation Overcomes the Adverse Prognostic Impact of CD20 Expression In Both Adult and Pediatric Acute Lymphoblastic Leukemia.
Authors: Veronika Bachanova, Karamjeet Sandhu, Daniel J. Weisdorf, Michael Verneris, Michael J Burke, Qing Cao
Journal: Blood (2010)
Global Phase I/III Pharmacokinetic and Efficacy Study Comparing CT-P10, a Biosimilar Candidate to the Rituximab Reference Product in Patients with Advanced Stage Follicular Lymphoma (AFL)
Authors: Won Seog Kim, Michinori Ogura, Christian Buske, Bertrand Coiffier, Juan-Manuel Sancho, Wojciech Jurczak, Jin Seok Kim, Raj V Nagarkar, Edvard Zhavrid, Jose Angel Hernandez Rivas, Yuriy Vinnyk, Panagiotis Tsirigotis, Piera Viero, Elena Volodicheva, Samuel Fourie, Juan Soler
Journal: Blood (2015)
Complex Alterations in Serum Cytokines and Increased Il-4 Levels Characterize Patients Developing Chronic Thrombocytopenia after Allogeneic Hematopoietic Cell Transplantation.
Authors: M. Elshal, Y. Takahashi, S. Chakrabarti, R. Srinivasan, D. Suffredini, T. Igarashi, S. Solomon, A. Lundqvist, A. J. Barrett, J. P. McCoy, Richard Childs
Journal: Blood (2004)
Mobilization and Elimination of FLT3-ITD+ Acute Myelogenous Leukemia (AML) Stem/Progenitor Cells by Plerixafor/G-CSF/Sorafenib: Results From a Phase I Trial in Relapsed/Refractory AML Patients
Authors: Michael Andreeff, Zhihong Zeng, Mary A Kelly, Rui-yu Wang, Teresa McQueen, Seshagiri Duvvuri, Gul Nowshad, Gautam Borthakur, Jan A. Burger, Tapan M. Kadia, Elias Jabbour, Jorge E. Cortes, Hagop M. Kantarjian, Marina Konopleva
Journal: Blood (2012)
OC-056 High Rate of Missed Visible Lesions in Patients Referred with Low Grade Dysplasia with Subsequent Upstaging of Pathology by EMR in Majority
Authors: I Koumoutsos, P Wilson, S DeMartino, J Dunn
Journal: Gut (2016)

<h3>Introduction</h3> Endoscopic therapy for Barrett’s oesophagus (BE) associated dysplasia or intramucosal cancer (IMC) has become the standard of care, and is recommended to occur in regional centres with high volume. Endoscopic mucosal resection (EMR) is often the first step as the majority of patients with high grade dysplasia (HGD) will have a visible lesion. This has been shown to upgrade HGD to more advanced pathology in over 30%. Little data exists on the use of EMR for low grade dysplasia (LGD). Aim of this study is to assess the rate of visible lesions in patients referred with LGD and outcomes of EMR. <h3>Methods</h3> Prospective study of patients undergoing BE dysplasia assessment at tertiary referral upper GI centre (GSTT). Surveillance endoscopy was performed with virtual chromoendoscopy (NBI) and conventional chromoendoscopy (acetic acid 2.5%) by two endoscopists, and EMR was undertaken, when feasible, to a visible lesion. Analysis was by independent t-tests for continuous variables and chi-squared tests for categorical variables. <h3>Results</h3> A total of 69 patients with BE underwent endoscopy, between 2014 and 2016. Results are shown in table 1. Patients were split into community pathology referral grade. There was no significant difference in patient’s age, sex or length of BE between the groups. EMR was undertaken to visible lesions in 84% of patients with HGD vs 54% with LGD. EMR was not performed due to advanced endoscopic lesions in 18% of patients referred with IMC, 13% with HGD and 4% for LGD. Pathology upstaging compared to the stage of the referring hospital was significantly higher in EMR specimens (50%) vs central pathology review of biopsies (19%) (p-value:0.001). There was no statistical difference in the rates of patients upstaged from EMR from patients referred with LGD vs HGD (64% vs 54%, p-value:0.75). In 3/26 (11%) of patients referred with LGD pathology of EMR specimen showed IMC. <h3>Conclusion</h3> This study demonstrates a high rate of missed visible lesions in patients diagnosed with LGD in a community setting, with half undergoing EMR. That these patients were upstaged to higher grades of dysplasia in 64% of the cases, indicates correct choice of EMR as a diagnostic modality in this group. Endoscopists carrying out surveillance endoscopy for patients with LGD should be aware of a high rate of visible lesions and advanced pathology, and consider referral to centre for further endoscopic evaluation. <h3>Disclosure of Interest</h3> None Declared
Tp63 Contributes to the Apoptosis Resistant Phenotype in Aggressive Chronic Lymphocytic Leukemia
Authors: Stavroula Ntoufa, Nikos Papakonstantinou, Despoina Papazoglou, Maria Tsagiopoulou, Sarka Pospisilova, Achilles Anagnostopoulos, Richard Rosenquist, Paolo Ghia, Kostas Stamatopoulos
Journal: Blood (2015)
AB1050 Factors of Work Disability in Patients with Rheumatoid Arthritis
Authors: T. Janković, J. Zvekic-Svorcan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatoid arthritis (RA) is a progressive disease which leads to early work disability. <h3>Objectives</h3> To determine the factors of work disability in patients with RA. <h3>Methods</h3> The study included 283 patients with RA in the Special Hospital for Rheumatic Diseases Novi Sad in the period of one year. Patients average age was 51.5 years (range 30–68), mean disease duration 11 years (range 2–37 years). All patients were treated with conventional DMARD9s and 38% got prednisolone,too. They were determined with disease activity-DAS28, HAQ-DI Health Assessment Questionnaire for Rheumatoid Arthritis and made a X-ray of hands and feet. All patients filled out a questionnaire that included questions related to education, qualifications, type of work, conditions of the workplace, motivisanos to work, distance and way of coming to work, the existence of some of the categories of disability and time of its creation, and the existence of other diseases. <h3>Results</h3> After 2 years of the disease, 99% of patients were able to work. After 5 years in 30% was required retraining, 10% had part-time work, while 9% of patients were permanently disabled for work. After 10 years of the disease in 50% of patients was required retraining, 10% had part-time work, while 40% was permanently work disabled. After 15 years, 61% of patients were permanently unable to work. After 23 years there was no working abled patients. The most common cause of work disability 32% was the weight of work that has been associated with a low level of education (p&lt;0.001) -without a professional education 50%, 42% high school education, 28% had high disease activity that is correlated with high values of HAQ-DI (p&lt;0.001). Poor working conditions as risk factors were present in 17%, the presence of concomitant diseases in 10% (57% cardio vascular diseases), lack of motivation to work in 8%, distance from work in 5%. <h3>Conclusions</h3> The lower level of education, heavier physical labor and poor working conditions in patients with high disease activity and low functional ability led to early work disability. Early and aggressive treatment of RA with conventional DMAR and biological medications, also as raising the level of education and the improvement of working conditions can affect the reduction of work disability after years of disease duration. <h3>References</h3> Ann Rheum Dis 2013;72:875–875. <h3>Disclosure of Interest</h3> None declared
Essential Role of γδT Cells In Naturally Acquired Immunity to Falciparum Malaria
Authors: Tomoyo Kanda-Taniguchi, Kaiissar Md. Mannoor, Changchun Li, Norihiro Watanabe, Akie Yamahira, Samlane Phompida, Miwako Narita, Hisami Watanabe, Masuhiro Takahashi
Journal: Blood (2010)
A Novel Perspective On Hematopoietic Stem/Progenitor Cell Migration and homing—evidence That Cationic Antimicrobial Peptides (C3a, LL-37, and β2-defensin) Prime (enhance) the Responsiveness of These Cells to a Low SDF-1 Gradient by Promoting Secretion of ATP, Indicating the Involvement of an Autocrine Purinergic Loop in Their Migration.
Authors: Gabriela Schneider, ChiHwa Kim, Janina Ratajczak, Mariusz Z Ratajczak
Journal: Blood (2012)
Persisting Hyperbilirubinemia in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Chronically Treated with Eculizumab: The Role of Hepatocanalicular Transport Variants
Authors: Ferras Alashkar, Ali Canbay, Dörte Herich-Terhürne, Ulrich Dührsen, Frank Lammert, Alexander Röth
Journal: Blood (2015)
Appropriate Use of High-Sensitivity Cardiac Troponin Levels in Patients With Suspected Acute Myocardial Infarction—Reply
Authors: Edward Carlton, Louise Cullen, Richard Body
Journal: JAMA Cardiology (2016)

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Sorafenib Affects Membrane Complement Inhibitors and Improves Antitumor Activity of Rituximab,
Authors: Jakub Golab, Jacek Bil, Kamil Bojarczuk, Dominika Nowis, Marcin Okroj, Grzegorz Basak, Tomasz Stoklosa, Magdalena Winiarska
Journal: Blood (2011)
Advances in Imaging Techniques and Genetically Encoded Probes for Photoacoustic Imaging
Authors: Chengbo Liu, Xiaojing Gong, Riqiang Lin, Feng Liu, Jingqin Chen, Zhiyong Wang, Liang Song, Jun Chu
Journal: Theranostics (2016)

Photoacoustic (PA) imaging is a rapidly emerging biomedical imaging modality that is capable of visualizing cellular and molecular functions with high detection sensitivity and spatial resolution in deep tissue.Great efforts and progress have been made on the development of various PA imaging technologies with improved resolution and sensitivity over the past two decades.Various PA probes with high contrast have also been extensively developed, with many important biomedical applications.In comparison with chemical dyes and nanoparticles, genetically encoded probes offer easier labeling of defined cells within tissues or proteins of interest within a cell, have higher stability in vivo, and eliminate the need for delivery of exogenous substances.Genetically encoded probes have thus attracted increasing attention from researchers in engineering and biomedicine.In this review, we aim to provide an overview of the existing PA imaging technologies and genetically encoded PA probes, and describe further improvements in PA imaging techniques and the near-infrared photochromic protein BphP1, the most sensitive genetically encoded probe thus far, as well as the potential biomedical applications of BphP1-based PA imaging in vivo.
The Stem Cell Factor-cKIT Pathway Must Be Inhibited to Enable Apoptosis Induced by Bcr-Abl Inhibitors in Chronic Myelogenous Leukaemia Cells
Authors: Francis Belloc, Kelly Airiau, Vanessa Augis, Marie Jeanneteau, Melissa Garcia, Estelle Guerin, Eric Lippert, François Moreau-Gaudry, Francois-Xavier Mahon
Journal: Blood (2008)