tbuckley/cabot-search huggingface dataset:
Smoke and Mirrors: Subverting Rationality, Positive Freedom, and Their Relevance to Nudging and/or Smoking Policies
Authors: Timothy Houk, Russell DiSilvestro, Mark Jensen
Journal: The American Journal of Bioethics (2016)

We find the argument of “Withdrawing Versus Withholding Freedom” (Schmidt 2016) to be interesting but incomplete in three related ways: (1) concerning the potential policy of antismoking nudges, (2...
Tandem Bone Marrow Transplantation in Multiple Myeloma
Authors: Wee J Chng
Journal: New England Journal of Medicine (2004)

1466 n engl j med 350;14 www.nejm.org april 1, 2004 1. Durie BG, Waxman AD, D’Aglono A, Williams CM. Wholebody 18 F-FDG PET identifies high-risk myeloma. J Nucl Med 2002; 43:1457-63. 2. Farrugia AN, Atkins GJ, To LB, et al. Receptor activator of nuclear factor-kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 2003;63:5438-45. 3. Heider U, Langelotz C, Jakob C, et al. Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma. Clin Cancer Res 2003;9:1436-40. 4. Giuliani N, Colla S, Sala R, et al. Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood 2002;100:4615-21. 5. Barille-Nion S, Bataille R. New insights in myeloma-induced osteolysis. Leuk Lymphoma 2003;44:1463-7.
Psychiatric consultations in a pediatric hospital
Authors: G A Awad, E O Poznanski
Journal: American Journal of Psychiatry (1975)

The authors conducted a study of 30 hospitalized children who were referred for psychiatric consultation and 60 hospitalized children who were not. They studied the medical charts of these children and administered a questionnaire including a checklist of behavioral symptoms to their parents. More psychopathology was found in the children referred for consultation, but about 20 percent of the children not referred also showed a high degree of psychopathology. Factors found to be associated with referral for psychiatric consultation were older age, longer hospital stay, many previous hospitalizations, and ambiguous diagnoses.
LG-39VISUAL ACUITY SURVEILLANCE IN PAEDIATRIC PATIENTS WITH OPTIC PATHWAY GLIOMA. EXPERIENCE IN A SPANISH SINGLE INSTITUTION
Authors: Miguel Garcia Ariza, Jaime Echevarria Ecenarro, Aizpea Echebarria, Rosa Adan, Ricardo Lopez Almaraz, Itziar Astigarraga, Aurora Navajas
Journal: Neuro-Oncology (2016)
CMR Survey In a Large Cohort Of TI Patients
Authors: Antonella Meloni, Maria-Eliana Lai, Stefania Vacquer, Roberto Mattei, Crocetta Argento, Domenico Maddaloni, Aurelio Maggio, Cristina Salvatori, Gennaro Restaino, Vincenzo Positano, Massimo Lombardi, Alessia Pepe
Journal: Blood (2013)
Case 26-1965
Authors: Jacob Lerman, Richard B. Cohen
Journal: New England Journal of Medicine (1965)

Presentation of CaseFirst admission. A sixty-eight-year-old man was admitted to the hospital because of weakness.He had been well until two months previously, when crampy pain developed in both lower quadrants of the abdomen, accompanied by urinary frequency; the pain persisted for one week. Three weeks later he began to have episodic weakness of the legs, which gradually became constant, interfering with walking and preventing the climbing of stairs. Anorexia, decreased alertness and a loss of 8 pounds in weight occurred. Three days before admission, while sitting quietly in a car, he suddenly lost consciousness for five minutes.He . . .
Asymptomatic Solitary Metastasis to the Testis From Prostate Carcinoma Detected by FDG PET/CT
Authors: Te-Chun Hsieh, Ching-Chan Lin, Chia-Hung Kao, Yu-Chin Wu, Shung-Shung Sun
Journal: Clinical Nuclear Medicine (2015)

Testicular metastases, despite their proximity, from prostate adenocarcinoma are rare and usually found along with bone or other visceral metastases. We herein present a case with recurrent disease of prostate adenocarcinoma as solitary testicular metastasis detected by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT).
QOS-10LONG TERM IMPACT ON MOBILITY IN CHILDREN WITH POSTERIOR FOSSA TUMOURS
Authors: Helen Hartley, Ram Kumar, Christine Sneade, Rebecca Williams, Barry Pizer
Journal: Neuro-Oncology (2016)

QOS-10. LONG TERM IMPACT ON MOBILITY IN CHILDREN WITH POSTERIOR FOSSA TUMOURS Helen Hartley, Ram Kumar, Christine Sneade, Rebecca Williams, and Barry Pizer; Alder Hey Childrens NHS Foundation Trust, Liverpool, UK OBJECTIVES: The objective of this study was to explore long term mobility problems in children following treatment for a posterior fossa tumour. It is recognized that children with brain tumours can present with long term motor problems and in particular ataxia. METHODS: 50 children (aged between 4-18 years of age) who were 2 years or more following resection of posterior fossa tumour were assessed using the PEDI (Paediatric Evaluation of Disability Index) mobility domain and the SARA (Scale for assessment and rating of ataxia). RESULTS: Overall 40% of children who were assessed recorded a PEDI mobility domain score more than 10% below the norm for their age. Examining the results according to tumour type; 17 children diagnosed with a medulloblastoma were assessed and 65% presented with a PEDI 10% or more below normative scores with average SARA score for this group9.5. In 7 children following treatment foran ependymoma57% presented with a PEDI 10% or more below normative scores and the average SARA score was 3.5, in 25 children with low grade gliomas 24% presented with a PEDI 10% or more below normative scores and their average SARA score was 3.5. CONCLUSIONS: A large proportion of children who have undergone treatment for posterior fossa tumours demonstrated a long term impact on functional mobility. PEDI score is lower and SARA score is higher in children with medulloblastomas though it is recognized that children with malignant tumours have adjunct treatment which can impact on physical presentation. Neuro-Oncology 18:iii145–iii158, 2016. doi:10.1093/neuonc/now081.10 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
NS-31ENDOSCOPIC THIRD VENTRICULOCISTERNOSTOMY FOR THE TREATMENT OF HYDROCEPHALUS IN CHILDREN WITH POSTERIOR FOSSA TUMORS
Authors: Oscar Garcia-Gonzalez, Paola Hernandez-Ponce
Journal: Neuro-Oncology (2016)

NS-31. ENDOSCOPIC THIRD VENTRICULOCISTERNOSTOMY FOR THE TREATMENT OF HYDROCEPHALUS IN CHILDREN WITH POSTERIOR FOSSA TUMORS Oscar Garcia-Gonzalez1,2 and Paola Hernandez-Ponce2; Hospital Regional de Alta Especialidad del Bajio, Leon, Guanajuato, Mexico; Hospital Aranda de la Parra, Leon, Guanajuato, Mexico OBJECTIVE: Retrospective study to evaluate the effectiveness of endoscopic third ventriculostomy (ETV) performed in children with posterior fossa tumors and hydrocephalus in an attempt to classify the selected cases who could benefit from ETV as a permanent CSF diversion procedure. METHODS: During the period between February 2013 and February 2016, 9 patients with posterior fossa tumors and associated hydrocephalus were treated inside the Hospital Regional de Alta Especialidad del Bajio and Hospital Aranda de la Parra in Leon, Mexico, with ETV in order to relieve the increased intracranial pressure while awaiting their definite tumor surgery. RESULTS: ETV was successful in relieving hydrocephalus clinically and radiologically in 6 patients with different posterior fossa pathologies. In the other 3 cases, preoperative ETV failed in permanently resolving hydrocephalus and patients required the insertion of a ventriculoperitoneal (VP) shunt after their posterior fossa surgery and during their follow-up period. CONCLUSIONS: ETV should be considered as an alternative procedure to VP shunt in controlling severe hydrocephalus related to posterior fossa tumors, to relieve symptoms during the preoperative period while patients await their definite tumor excision. Eliminates the risks of cerebrospinal fluid (CSF) infection related to external drainage. Since preoperative hydrocephalus is veryoften physicallyobstructive,ETV shouldalways be considered a possible treatment procedure. Neuro-Oncology 18:iii127–iii134, 2016. doi:10.1093/neuonc/now078.31 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PCM-17INTRATUMOURAL CONVECTION ENHANCED DELIVERY OF LBH589 (PANOBINOSTAT) LOADED PLURONIC-P407 NANO-MICELLES IS ASSOCIATED WITH ENHANCED SURVIVAL AND ANTI-TUMOUR RESPONSE IN THE ORTHOTOPIC F98/FISCHER 344 RAT GLIOMA MODEL
Authors: William G.B. Singleton, Alison S. Bienemann, Clare L. Killick-Cole, Andrew M. Collins, Harry R. Haynes, Lisa J. Boulter, Marcella J. Wyatt, Daniel J. Asby, Neil U. Barua, Stephen P. Lowis, Steven S. Gill
Journal: Neuro-Oncology (2016)

The pan-histone deacetylase inhibitor LBH598 is a potential therapy for malignant supratentorial and brainstem glioma but is water insoluble and does not cross the blood brain barrier when administered systemically.We Overall survival
Abstract LB-105: Methanol extract of Cochrorus olitorus protects against potassium dichromate toxicity in albino rats
Authors: Olabode O. Osifeso, Kazeem A. Akinwumi, Ayobami W. Adedoja
Journal: Cancer Research (2015)

Abstract Hexavalent chromate compounds are human carcinogens that pose great health hazard in several parts of the world especially in developing countries. In addition, an effective cure eludes the world. The study therefore evaluates the usefulness of the leafy vegetable and herb; Cochrorus olitorus (CO) against potassium chromate K2Cr2O7. Negative control animals were fed distilled water, while the positive control rats received K2Cr2O7 once per week. Test rats were exposed to 25, 50 and 100 mg/Kg body weight of CO alone for 42 days and / or 12 mg/kg body wt of K2Cr2O7 once per week before the animals were sacrificed. The frequency of micronucleated polychromatic erythrocytes (mPCEs) was monitored in bone marrow cells while aspartate aminotransferase (AST), alanine aminotransferase (ALT) and creatine levels were assessed in the serum. Haematological parameters were also monitored in test and control animals. The phytochemical analysis of CO was also carried out. K2Cr2O7 significantly (P&amp;lt;0.05) increased the levels of mPCE, AST, ALT, creatine, total white blood cells and lymphocytes as compared with the control. While percentage pack cell volume and neutrophils were reduced. In contrast, treatment with the different doses of CO restored the markers towards the levels of the negative control. Methanolic extract of CO is rich in flavonoids, saponins, anthraquinnones, terpernoid and phenols which may be responsible for the protection observed in this study. Our results suggest that methanol extract of CO has potentials in the treatment/management of chromate toxicity. Note: This abstract was not presented at the meeting. Citation Format: Olabode O. Osifeso, Kazeem A. Akinwumi, Ayobami W. Adedoja. Methanol extract of Cochrorus olitorus protects against potassium dichromate toxicity in albino rats. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-105. doi:10.1158/1538-7445.AM2015-LB-105
Virus of Avian Erythroblastosis. VI. Further Studies on Neutralization by Antiserum to Normal Chicken Protein&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Dorothy Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1957)

Virus of Avian Erythroblastosis. VI. Further Studies on Neutralization by Antiserum to Normal Chicken Protein Get access Dorothy Beard, Dorothy Beard Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Beard J. W. Beard Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 5, November 1957, Pages 923–939, https://doi.org/10.1093/jnci/19.5.923 Published: 01 November 1957 Article history Received: 27 May 1957 Published: 01 November 1957
MB-89TREATMENT FAILURE IN YOUNG CHILDREN WITH DESMOPLASTIC MEDULLOBLASTOMA (DMB)/MEDULLOBLASTOMA WITH EXTENSIVE NODULARITY (MBEN) TREATED ACCORDING TO THE HIT PROTOCOLS
Authors: Nicolas U. Gerber, Björn-Ole Juhnke, Martin Mynarek, Martin Benesch, Anne Isabelle Bertozzi, Rolf-Dieter Kortmann, Torsten Pietsch, Monika Warmuth-Metz, Shaun Wilson, Olga Zhedludkova, Katja von Hoff
Journal: Neuro-Oncology (2016)
Gastric Cancer Experimentally Induced in Insects by Nerve Severance&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: B SCHARRER
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article Gastric Cancer Experimentally Induced in Insects by Nerve Severance Get access Berta Scharrer Berta Scharrer University of Colorado Medical Center, Denver, Colo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 375–376, https://doi.org/10.1093/jnci/10.2.375 Published: 01 October 1949
MB-82THE TRANSCRIPTIONAL LANDSCAPE OF MEDULLOBLASTOMA: GROUP 3 AND GROUP 4 TUMOURS COMPRISE A SINGLE CLINICALLY SIGNIFICANT EXPRESSION CONTINUUM
Authors: Daniel Williamson, Janet C. Lindsey, Debbie Hicks, Stephen Crosier, Amanda Smith, Matthew Bashton, Rebecca Hill, Abhijit Joshi, Thomas S. Jacques, Edward C. Schwalbe, Simon Bailey, Steven C. Clifford
Journal: Neuro-Oncology (2016)

Transcriptome sequencing provides a far more precise and informative view of tumour RNA biology than has hitherto been available using array-based methods.We sequenced the transcriptomes of 253 primary medulloblastomas (MB; 90M paired-end reads) with full clinical annotation, methylation and copy number profiles.MB may be defined as four transcriptional subgroups, however the increased precision of RNA-seq shows Group3/Group4 tumours exist along a dichotomous continuum of expression whereby tumours may exist as a series of intermediates.Moreover, this continuum is clinically significant; the more "Group3-like" an individual the greater the frequency of high-risk clinico-pathological/biological features (e.g.MYC amplification/LCA pathology) and risk of death.Deriving a score to denote an individual's position along the continuum significantly outperforms the four-subgroup model as a survival predictor.Pathway analysis reveals a strong correlation of the continuum with MYC and MYC target expression and reveals CRX, OTX2 and PRC2 as master regulators of the Group3 phenotype.We catalogued several hundred sub-group specific transcriptional isoforms, promoter switches, novel transcripts with coding potential, fusion gene transcripts, RNA single-nucleotide variants (including RNA-editing) and allele specific expression events.Several of these novel transcriptional events were validated by RT-PCR/sequencing.Fusion transcripts were nonrandom with respect to chromosome/sub-group, but with the exception of PVT1 (and less frequently SUFU and MYCN) gene fusions, were not recurrent events in MB.These findings provide a first detailed landscape of the MB transcriptome, and raise important questions regarding the distinct nature of Group3/4 tumours, in particular their relationships to developmental origins and clinical behaviour.
The Concentration of Myelokentric and Lymphokentric Acids from Serum and Plasma of Leukemic Patients2
Authors: D. L. Turner, F. R. Miller, J. S. Flint
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article The Concentration of Myelokentric and Lymphokentric Acids from Serum and Plasma of Leukemic Patients Get access D. L. Turner, D. L. Turner Search for other works by this author on: Oxford Academic PubMed Google Scholar F. R. Miller, F. R. Miller Search for other works by this author on: Oxford Academic PubMed Google Scholar J. S. Flint J. S. Flint Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 2, October 1953, Pages 439–448, https://doi.org/10.1093/jnci/14.2.439 Published: 01 October 1953 Article history Received: 13 May 1953 Published: 01 October 1953
Performance of case definitions for influenza surveillance
Authors: L Jiang, V J Lee, W Y Lim, M I Chen, Y Chen, L Tan, R T Lin, Y S Leo, I Barr, A R Cook
Journal: Eurosurveillance (2015)

Influenza-like illness (ILI) case definitions, such as those from the European Centre for Disease Control and Prevention, World Health Organization (WHO) and United States Centers for Disease Control and Prevention, are commonly used for influenza surveillance. We assessed how various case definitions performed during the initial wave of influenza A(H1N1) pdm09 infections in Singapore on a cohort of 727 patients with two to three blood samples and whose symptoms were reviewed fortnightly from June to October 2009. Using seroconversion (≥ 4-fold rise) to A/California/7/2009 (H1N1), we identified 36 presumptive influenza A(H1N1)pdm09 episodes and 664 episodes unrelated to influenza A(H1N1)pdm09. Cough, fever and headache occurred more commonly in presumptive influenza A(H1N1)pdm09. Although the sensitivity was low (36%), the recently revised WHO ILI case definition gave a higher positive predictive value (42%) and positive likelihood ratio (13.3) than the other case definitions. Results including only episodes with primary care consultations were similar. Individuals who worked or had episodes with fever, cough or sore throat were more likely to consult a physician, while episodes with Saturday onset were less likely, with some consultations skipped or postponed. Our analysis supports the use of the revised WHO ILI case definition, which includes only cough in the presence of fever defined as body temperature ≥ 38 °C for influenza surveillance.
Some neurophysiologic aspects of individual behavior
Authors: B J Betz
Journal: American Journal of Psychiatry (1979)

The author provides a brief primer of the biologic processes in the brain that produce affect and implement communication. These neuroanatomic and neurophysiologic processes are presented in broad configuration rather than in detail and as distributive systems rather than just as localized mechanisms. The basic viewpoint is that of a continuum between the biologic processes within the brain and their manifestation as behavioral phenomena expressed in, and visible to, the culture. The primary focus is not clinical but on neuroanatomy and neurophysiology as basic medical sciences for psychiatry.
The Phenol-Oxidizing Enzyme System of Human Melanomas; Substrate Specificity and Relationship to Copper&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Denis Kertész
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article The Phenol-Oxidizing Enzyme System of Human Melanomas; Substrate Specificity and Relationship to Copper Get access Denis Kertész Denis Kertész Research Department, Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 5, April 1954, Pages 1081–1091, https://doi.org/10.1093/jnci/14.5.1081 Published: 01 April 1954 Article history Received: 27 July 1953 Published: 01 April 1954
Somatic and Germline <i>TP53</i> Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors
Authors: Amy L. Sherborne, Vincent Lavergne, Katharine Yu, Leah Lee, Philip R. Davidson, Tali Mazor, Ivan V. Smirnoff, Andrew E. Horvai, Mignon Loh, Steven G. DuBois, Robert E. Goldsby, Joseph P. Neglia, Sue Hammond, Leslie L. Robison, Rosanna Wustrack, Joseph F. Costello, Alice O. Nakamura, Kevin M. Shannon, Smita Bhatia, Jean L. Nakamura
Journal: Clinical Cancer Research (2016)

Purpose: Second malignant neoplasms (SMNs) are severe late complications that occur in pediatric cancer survivors exposed to radiotherapy and other genotoxic treatments. To characterize the mutational landscape of treatment-induced sarcomas and to identify candidate SMN-predisposing variants, we analyzed germline and SMN samples from pediatric cancer survivors.Experimental Design: We performed whole-exome sequencing (WES) and RNA sequencing on radiation-induced sarcomas arising from two pediatric cancer survivors. To assess the frequency of germline TP53 variants in SMNs, Sanger sequencing was performed to analyze germline TP53 in 37 pediatric cancer survivors from the Childhood Cancer Survivor Study (CCSS) without any history of a familial cancer predisposition syndrome but known to have developed SMNs.Results: WES revealed TP53 mutations involving p53's DNA-binding domain in both index cases, one of which was also present in the germline. The germline and somatic TP53-mutant variants were enriched in the transcriptomes for both sarcomas. Analysis of TP53-coding exons in germline specimens from the CCSS survivor cohort identified a G215C variant encoding an R72P amino acid substitution in 6 patients and a synonymous SNP A639G in 4 others, resulting in 10 of 37 evaluable patients (27%) harboring a germline TP53 variant.Conclusions: Currently, germline TP53 is not routinely assessed in patients with pediatric cancer. These data support the concept that identifying germline TP53 variants at the time a primary cancer is diagnosed may identify patients at high risk for SMN development, who could benefit from modified therapeutic strategies and/or intensive posttreatment monitoring. Clin Cancer Res; 23(7); 1852-61. ©2016 AACR.
PNR-33MOLECULAR RE-EVALUATION OF INSTITUTIONALLY DIAGNOSED CNS-PNETS: CLINICAL CONSEQUENCES OF CONFINED DIAGNOSTIC GROUPS
Authors: Katja von Hoff, Jordan R. Hansford, Giles Robinson, Eugene Hwang, Sarah Leary, Barry Pizer, Dannis G. van Vuurden, Christelle Dufour, David Sumerauer, Michal Zapotocky, Marta Perek, Miklos Garami, Maura Massimino, Maria Joao Gil da Costa, Ella Kumirova, Jaroslav Sterba, Sandra Jacobs, Martin Benesch, Nicolas U. Gerber, Birgitta Lannering, Tom Davidson, Jonathan L. Finlay, Martin Mynarek, B. Ole Juhnke, Stefan Rutkowski, Robert Kwiecien, Dominik Sturm, David Capper, Steven C. Clifford, Felice Giangaspero, Peter Hauser, Maria Lastowska, Christine Haberler, Torsten Pietsch, Stefan Pfister, James Olson, Nicholas G. Gottardo, Marcel Kool
Journal: Neuro-Oncology (2016)