tbuckley/cabot-search huggingface dataset:
AB0775 The Diagnostic Value of the Asas Recommendations for Early Referral of Axial Spondyloarthritis in Primary Care Patients with Chronic Low Back Pain
Authors: L. Van Hoeven, Y. Vergouwe, P. de Buck, K. Han, J. Luime, J. Hazes, A. Weel
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> There is a delay between the onset of the first back pain symptoms and the final diagnosis of axial spondyloarthritis (axSpA). This delay can be explained by difficulties for primary care physicians to recognize and subsequently refer potential axSpA patients in the huge number of chronic low back pain (CLBP) patients seen in primary care. At this moment there is no widely accepted referral strategy. Recently the ASAS workgroup proposed recommendations for early referral although these were not yet validated in a primary care setting. <h3>Objectives</h3> To test the ASAS proposed recommendations for early referral in a primary care setting. <h3>Methods</h3> Our study population included primary care patients (18-45 years) with CLBP (≥3 months, age at back pain onset &lt;45 years) from two Dutch cross-sectional studies. No specific axSpA features were used to include patients. Patients already diagnosed with ankylosing spondylitis were not invited. Patients underwent a diagnostic work-up, including a standardized history, physical examination, HLA-B27 and CRP. A conventional radiograph and MRI of the sacroiliac joints was obtained. Definite axSpA was defined by the ASAS criteria. The ASAS recommendations are applicable in patients with CLBP (≥3 months) and back pain onset before 45 years and should be referred if at least one of the following parameters is present: inflammatory back pain, HLA-B27 positivity, sacroillitis on imaging (X-ray or MRI), peripheral manifestations (arthritis, enthesitis, dactylitis), extra-articulair manifestations (psoriasis, inflammatory bowel disease, uveitis), positive family history for SpA, good response to non-steroidal anti-inflammatory drugs (NSAIDs), elevated acute phase reactants. To test these recommendations, sensitivity, specificity and positive predictive value were calculated. <h3>Results</h3> In total 941 primary care CLBP patients participated (58% female, mean age 36.0 years), of those were 181 (19%) identified as axSpA, 54 of the 181 (30%) were newly diagnosed with ankylosing spondylitis. 773 (82%) patients had at least one parameter present and thus according to the recommendations should be referred to the rheumatologists. The sensitivity of the ASAS recommendation is 100% (181/181), the specificity 22% (168/760) and the positive predictive value 23% (181/773) (Table 1). <h3>Conclusions</h3> The ASAS recommendation for early referral has a perfect sensitivity in primary care CLBP population. However this comes at the cost of a low specificity, meaning that almost 80% of the referred patients will undergo unnecessary diagnostic work up. A more specific referral strategy will be needed in daily primary care. <h3>Acknowledgements</h3> An unrestricted research grant was provided by AbbVie. <h3>Disclosure of Interest</h3> None declared
Psychiatric consultation in an HMO: a model for education in primary care
Authors: L F Rittelmeyer, W E Flynn
Journal: American Journal of Psychiatry (1978)

The authors describe a program based on a biopsychosocial model of illness, which uses a liaison-consultation approach in an outpatient setting. It is directed toward integrating psychiatric education and services with primary care in a health maintenance organization. This program can serve as a useful model for studying the validity and effectiveness of integrating psychiatric concepts with primary health care.
New female perceptions of parental power
Authors: J F McDermott, J A Waldron, W F Char, J Ching, S Izutsu, E Mann, D E Ponce, C Fukunaga
Journal: American Journal of Psychiatry (1987)

In a study of family roles, 85 adolescent sons and daughters from 27 families initially attributed "power" roles to fathers and "support" roles to mothers. Three years later, daughters perceived power and support roles as shared, while sons still perceived the earlier dichotomy.
Case 2-1981
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Stephen W. Parker, Edward P. Richardson
Journal: New England Journal of Medicine (1981)

Presentation of CaseA 24-year-old man was admitted to the hospital because of collapse.He was well until 17 months earlier, when he received a shotgun blast in the face, without loss of consciousness. He was taken to the Emergency Ward, where examination showed a massive cavity that involved the nose, mouth, and chin. Fractures of the left mandible and both zygomas and a comminuted fracture of the nose and the right orbital floor were demonstrated on x-ray films (Fig. 1). The left orbital floor was absent, as were the anterior antral walls and the hard palate. A tracheostomy was . . .
Chromosome Analysis of a Human Ovarian Cystocarcinoma in the Ascites Form
Authors: E HANSEN-MELANDER, S KULLANDER, Y MELANDER
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Chromosome Analysis of a Human Ovarian Cystocarcinoma in the Ascites Form Get access Eva Hansen-Melander, Eva Hansen-Melander Cancer Chromosome Laboratory, Institute of Genetics, and Clinic of Obstetrics and Gynecology, Lund, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Stig Kullander, Stig Kullander Cancer Chromosome Laboratory, Institute of Genetics, and Clinic of Obstetrics and Gynecology, Lund, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Yngve Melander Yngve Melander Cancer Chromosome Laboratory, Institute of Genetics, and Clinic of Obstetrics and Gynecology, Lund, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 5, April 1956, Pages 1067–1081, https://doi.org/10.1093/jnci/16.5.1067 Published: 01 April 1956 Article history Received: 09 May 1955 Published: 01 April 1956
Immune cells from patients with psoriasis are defective in inducing indoleamine 2,3-dioxygenase expression in response to inflammatory stimuli
Authors: M. Llamas-Velasco, P. Bonay, M. José Concha-Garzón, L. Corvo-Villén, A. Vara, D. Cibrián, A. Sanguino-Pascual, F. Sánchez-Madrid, H. de la Fuente, E. Daudén
Journal: British Journal of Dermatology (2016)

Indoleamine 2,3-dioxygenase (IDO) is an inducible enzyme that suppresses the immune response. The role of IDO as a negative regulator of inflammatory responses has been documented in several experimental autoimmune diseases.To explore the regulation of IDO by immune cells in psoriasis and its relation with disease severity.The expression and activity of IDO were assessed by reverse-transcriptase polymerase chain reaction, flow cytometry and high-performance liquid chromatography in peripheral blood of patients with moderate-to-severe plaque-type psoriasis. The ability of immune cells to express IDO in response to inflammatory stimuli was studied. The functional role of IDO expression was evaluated in a regulatory T cell (Treg) differentiation assay, using cocultures of immature monocyte-derived dendritic cells with autologous peripheral CD4+ T cells.Analysis of the kynurenine-to-tryptophan ratio in serum samples indicated higher IDO activity in patients with psoriasis than in healthy controls. However, correlation studies showed lower IDO activity in those patients with higher Psoriasis Area and Severity Index (PASI). Although myeloid dendritic cells from patients with psoriasis expressed higher levels of IDO than those from healthy controls, these cells did not upregulate IDO in response to a combination of tumour necrosis factor-α, interleukin (IL)-1β and IL-6 cytokines. The defective expression of IDO correlated with PASI. Immature monocyte-derived dendritic cells from patients with psoriasis also expressed low levels of IDO and induced CD4+ Treg differentiation poorly.Immune cells from patients with psoriasis have a defect in upregulating IDO in response to inflammation associated with the severity of psoriasis.
Hierarchy of characteristics associated with depressive symptoms in an urban elderly sample
Authors: G J Kennedy, H R Kelman, C Thomas, W Wisniewski, H Metz, P E Bijur
Journal: American Journal of Psychiatry (1989)

In contrast to the uncertainty about the prevalence and importance of late-life depressive disorders, a consistent pattern of risk factors for depressive symptoms has been shown by studies using the Center for Epidemiologic Studies Depression Scale (CES-D). The authors surveyed a representative sample of 2,137 elderly community residents with the CES-D and found a hierarchy of characteristics associated with substantial levels of depressive symptoms: illness, disability, isolation, bereavement, and poverty. If these findings are confirmed by prospective studies, addressing modifiable factors in the emergence, persistence, and remission of depressive symptoms might extend the independent survival of older adults.
Soundings: Advice to science writers
Authors: Imre Loefler
Journal: BMJ (2006)

Make sure that you indicate in the introduction to your paper that the problem you are addressing is of the utmost importance to the survival of mankind. If the topic is a “disease,” quantify the proportion of the world population that might become its victims, calculate that proportion in absolute numbers, and proceed to address the annual expense that humanity incurs in consequence of that disease.

Never admit that your choice of research topic has been motivated by anything other than utilitarian concern for the common good. It would be a mistake to declare that you were driven by curiosity, that the matter you elected to scrutinise is esoteric, or that you stumbled upon your research topic by chance.

If animals make up your study sample, enumerate all the steps that you took to treat them humanely. Make it clear that they had excellent food, plenty of water, sunlight, space in which to run around, toys, swings, a pool, snow or hot sand, as appropriate, and that they were allowed to have sex while waiting to be decapitated or whatever else was the charitable means of their demise.

When you describe your methods, never omit a detail, however trivial. Always give the name of the producer of the syringe that you used and specify the basic material from which the tubes that you inserted were made.

When reporting on the results, calculate the percentages to at least two decimal places. The more numbers that the “Results” contain, the more scientific the paper is. Use at least two statistical methods in which p values are mandatory.

The “Discussion” is the literary part of every paper. It can take the shape of drama, it can be made to sound like a heroic epic or a sonnet, or it can consist of dry, crisp prose. It can be aggressive towards others who have examined the same problem previously, or it can be accommodating, laudatory. (These differences in style are generally not determined by the topic or even by the author's temperament, but by social position and career expectations.)

In the “Conclusions,” there is only one important sentence, of two parts—one stating that you made a breakthrough and the other that more research is needed.
Maintenance of training effects on the Wisconsin Card Sorting Test by patients with schizophrenia or affective disorders
Authors: J T Metz, M D Johnson, N H Pliskin, D J Luchins
Journal: American Journal of Psychiatry (1994)

The authors used the Wisconsin Card Sorting Test to study 50 hospitalized psychiatric patients: 28 with schizophrenia, 17 with affective disorders, and five with schizoaffective disorder. The schizophrenic patients performed significantly more poorly than the patients with affective disorders. Both groups of patients improved when given additional instructions. The schizophrenic patients maintained their improvement when retested approximately 6 weeks later. The results suggest that factors other than frontal cortex dysfunction are involved in schizophrenic patients' performance on the Wisconsin Card Sorting Test.
Myasthenia Gravis
Authors: Janet M. Torpy
Journal: JAMA (2005)

Myasthenia GravisM yasthenia gravis is an autoimmune disease that gradually causes muscles to lose their strength and function.Autoimmune diseases are caused by the body making substances called antibodies that attack a person' s own tissues.In myasthenia gravis, these antibodies are made against receptors in the neuromuscular junction (the area where nerve transmission makes a muscle do its work).Myasthenia gravis affects individuals differently, and each person may present with weakness in different sets of muscles.The April 20, 2005, issue of JAMA includes an article about diagnosing myasthenia gravis.
Intracellular Distribution of Enzymes. VI. The Distribution of Succinoxidase and Cytochrome Oxidase Activities in Normal Mouse Liver and in Mouse Hepatoma
Authors: Walter C. Schneider, George H. Hogeboom
Journal: JNCI Journal of the National Cancer Institute (1950)

Intracellular Distribution of Enzymes. VI. The Distribution of Succinoxidase and Cytochrome Oxidase Activities in Normal Mouse Liver and in Mouse Hepatoma Get access Walter C. Schneider, Walter C. Schneider Search for other works by this author on: Oxford Academic PubMed Google Scholar George H. Hogeboom George H. Hogeboom National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 4, February 1950, Pages 969–975, https://doi.org/10.1093/jnci/10.4.969 Published: 01 February 1950 Article history Received: 19 December 1949 Published: 01 February 1950
Brief Communication: Cage for Continuous Intravascular Infusion of Isotopes and Drugs in Small Animals2
Authors: Flora H. Grantham, Donald M. Hill, Jesse Rowland, Pietro M. Gullino
Journal: JNCI Journal of the National Cancer Institute (1975)

A cage for continuous intra-arterial or intravenous infusion is described. Major features are: a) The animal is free to move during infusion, b) loss of the infused solution is avoided, c) cleaning and decontamination are simple, and d) infusion can continue for weeks.
OP0158-PARE Lack of Patient Public Engagement at Introduction of a New Model of Community Dmard Monitoring: Table 1.
Authors: L. Ball, J. Kirk, T. Mirando, E. Edwards, B. Colaco
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Our local clinical commissioning group (LCCG) introduced a protocol for DMARD blood and clinical monitoring by GPs for stable inflammatory arthritis (<i>excluding those on biologics</i>). This reduces patient contact with the secondary care team to an annual review visit, with 3-5 interim primary care consultations over the course of a year. The LCCG expects to reduce hospital attendance for 1500 patients who are reviewed twice a year, thus reducing hospital visits by 3000 per year. <h3>Objectives</h3> The CMH patient self-help group considered that this change in policy may improve patient safety. We wished to examine patient views on any other impact (positive or negative) it may have on continuity and quality of care and their perception of the level of patient public engagement. <h3>Methods</h3> A patient questionnaire was constructed to assess the patient9s views on the change in protocol and the impact they felt it would have on their continuity and quality of care. The questionnaire was designed on survey monkey and consisted of 10 questions. The Likert Scale of scoring was implemented to answer each question. The questionnaire was emailed to all registered patient members under the care of the Rheumatology Unit at Central Middlesex Hospital. Of 370 recipients 130 opened the email, 65 reviewed the questionnaire and 46 responded in confidence via Survey Monkey. Patients were on one of four main DMARDS used (methotrexate, azathioprine, hydroxychloquine and sulfasalazine). Details of methods and all data will be published on the poster. <h3>Key results</h3> PPE: 86.96% of respondents (n=40) had not previously heard about the new policy and a further question regarding Patient Public Engagement noted 78.72% (n=37) had felt disenfranchised. <h3>Conclusions</h3> Patient responses to the questionnaire, regarding the impact of a well-intentioned GP led DMARD safety monitoring initiative, highlighted concerns about potential loss of quality and continuity of care. Surprisingly however, the perception that patient safety may be compromised imposes a responsibility to re-audit this process. The patient group felt disenfranchised by a lack of Patient Public Engagement in the development of this new protocol. <h3>Disclosure of Interest</h3> None declared
Testicular Cancer
Authors: _ _
Journal: Journal of the National Comprehensive Cancer Network (2006)

An estimated 8250 new cases of testicular cancer will be diagnosed in the United States in 2006, with germ cell tumors (GCTs) constituting 95% of the malignant tumors arising in the testes. Although GCTs are relatively uncommon tumors, they are the most common solid tumor in men between the ages of 15 and 34 years. The worldwide incidence of these tumors has more than doubled in the past 40 years. More than 90% of all patients diagnosed with GCTs are cured, including 70% to 80% of patients with advanced tumors who are treated with chemotherapy. Standard therapy has been established at essentially all stages of management and must be closely followed to ensure the potential for cure. For the most recent version of the guidelines, please visit NCCN.org
The Dance
Authors: Thomas B. Cole
Journal: JAMA (2013)

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SIRFLOX: Randomized phase III trial comparing first-line mFOLFOX6 ± bevacizumab (bev) versus mFOLFOX6 + selective internal radiation therapy (SIRT) ± bev in patients (pts) with metastatic colorectal cancer (mCRC).
Authors: Peter Gibbs, Volker Heinemann, Navesh K. Sharma, Michael P. N. Findlay, Jens Ricke, Val Gebski, Mark Van Buskirk, Guy A. Van Hazel
Journal: Journal of Clinical Oncology (2015)

3502 Background: The SIRFLOX study was designed to assess the efficacy and safety of combining FOLFOX chemotherapy (± bev) with SIRT using yttrium-90 (Y-90) resin microspheres as first-line treatment of pts with liver metastases from mCRC. Methods: SIRFLOX was an international, multi-center, open-label, RCT in chemotherapy-naïve pts with non-resectable, liver only or liver dominant (liver plus lung and/or lymph node metastases) mCRC. Arm A: mFOLFOX6 ± bev was compared to arm B: mFOLFOX6 + SIRT (SIR-Spheres; Sirtex) administered once with cycle 1 ± bev until disease progression. The primary endpoint was progression free survival (PFS) using RECIST v1.0. Stratification variables included presence of extra hepatic disease (EHD; liver only v liver dominant), degree of liver involvement ( ≤ 25% v > 25%), and treatment with bev (at clinician discretion). Results: From Oct 2006 to Apr 2013,530 pts were randomised (arm A, n = 263; arm B, n = 267), 212 (40%) had EHD. Median follow-up was 36.1 months. The median overall PFS was 10.2 v 10.7 months in arms A v B respectively (hazard ratio [HR]: 0.93; 95% CI 0.77–1.12; p=0.428) by Kaplan Meier analysis. The median PFS in the liver was 12.6 v 20.5 months in arm A v B (HR: 0.69; 95% CI 0.55–0.90; p = 0.002) by competing risk analysis. Overall response rate (PR + CR) was 68.0% v 76.4% in arm A v B, respectively (p = 0.113). Hepatic response rate was 68.8% v 78.7% in arm A v B (p = 0.042), including CR rate 1.9% v 6.0% (p = 0.02). The liver resection rate was 13.7% v 14.2% in arm A v B (p = 0.857). Adverse events ≥ grade 3 were noted in 73.3% v 85.4% of pts in arm A v B. Most common toxicities were hematologic; 32.9% v 51.2% and gastrointestinal; 21.2% v 32.9%, including gastric ulcer 0.0% v2.4%. Conclusion: In first-line treatment of pts with non-resectable CRC liver metastases, the addition of SIRT to standard chemotherapy failed to improve overall PFS. However, median liver PFS was significantly extended. The addition of SIRT was associated with acceptable toxicity. Overall survival analyses, combining data from SIRFLOX and two other ongoing studies in this disease setting, are awaited. Clinical trial information: NCT00724503.
Optimizing novel implant formulations for the prolonged release of biopharmaceuticals using in vitro and in vivo imaging techniques
Authors: Susanne Beyer, Li Xie, Mike Schmidt, Natasja de Bruin, Mukul Ashtikar, Sabrina Rüschenbaum, Christian M. Lange, Vitali Vogel, Werner Mäntele, Michael J. Parnham, Matthias G. Wacker
Journal: Journal of Controlled Release (2016)
Molecular Characterization Of Adult T-Cell Leukemia/Lymphoma
Authors: Yasunobu Nagata, Akira Kitanaka, Masashi Sanada, Aiko Sato, Yusuke Okuno, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Tetsuichi Yoshizato, Ayana Kon, Kenichi Yoshida, Ken Ishiyama, Shuichi Miyawaki, Satoru Miyano, Kazuya Shimoda, Seishi Ogawa
Journal: Blood (2013)