tbuckley/cabot-search huggingface dataset:
Morphology and Classification of Ovarian Neoplasms in F344 Rats and (C57BL/6 × C3H)F&lt;sub&gt;1&lt;/sub&gt; Mice
Authors: R H Alison, K T Morgan, J K Haseman, G A Boorman
Journal: JNCI Journal of the National Cancer Institute (1987)

For the updating of the National Toxicology Program (NTP) classification system for rat and mouse ovarian tumors, all the primary ovarian tumors from the archives of the National Cancer Institute and NTP Carcinogenesis Testing Programs were reviewed. The relative frequency and principal diagnostic features of 204 ovarian tumors from 39,851 female F344 rats and of 587 ovarian tumors from 41,102 female (C57BL/6 X C3H)F1 (B6C3F1) mice were described. The most frequently observed neoplasms in F344 rats were malignant granulosa cell tumors (29% of primary rat ovarian neoplasms observed), benign undifferentiated sex cord-stromal tumors (26%), benign granulosa cell tumors (16%), and benign Sertoli cell tumors (7%). The most frequent neoplasms in B6C3F1 mice were cystadenomas (24%), tubulostromal adenomas (24%), benign granulosa cell tumors (21%), and benign teratomas (8%). Ovarian neoplasms were not significantly related to treatment in rats. Tubulostromal adenomas, benign and malignant granulosa cell tumors, and benign teratomas were significantly more frequent in treated mice than in controls.
Case 42-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, M. Stuart Strong, Ben Z. Pilch
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 34-year-old man was brought to the hospital after cardiopulmonary arrest.The patient had enjoyed good health, without known hypersensitivity to medications. He was believed to have received penicillin for pneumonia while in the armed forces. One week before admission malaise and fever developed, accompanied by a sore throat. On the day before entry the muscles of his right arm and shoulder began to ache. At 11 o'clock that evening he was seen at another hospital because of an extremely painful sore throat. Examination disclosed pharyngeal inflammation but no local lymphadenopathy. A throat culture was obtained, and . . .
N-WASP is required for B-cell–mediated autoimmunity in Wiskott-Aldrich syndrome
Authors: Stefano Volpi, Elettra Santori, Katrina Abernethy, Masayuki Mizui, Carin I. M. Dahlberg, Mike Recher, Kelly Capuder, Eva Csizmadia, Douglas Ryan, Divij Mathew, George C. Tsokos, Scott Snapper, Lisa S. Westerberg, Adrian J. Thrasher, Fabio Candotti, Luigi D. Notarangelo
Journal: Blood (2015)
BMI, leisure-time physical activity, and physical fitness in adults in China: results from a series of national surveys, 2000–14
Authors: Ye Tian, Chongmin Jiang, Mei Wang, Rui Cai, Yanfeng Zhang, Zihong He, Huan Wang, Dongming Wu, Fubaihui Wang, Xin Liu, Zhongtao He, Ping An, Munan Wang, Qiang Tang, Yang Yang, Jin Zhao, Shaojun Lv, Weihai Zhou, Bo Yu, Jiang Lan, Xinping Yang, Linxia Zhang, Hui Tian, Zhuangzhuang Gu, Yiqing Song, Tianyi Huang, Lars R McNaughton
Journal: The Lancet Diabetes & Endocrinology (2016)
Peroral transhepatic cholangioscopy-guided electrohydraulic lithotripsy via an endoscopic ultrasonography-guided hepaticogastrostomy route for bile duct stones in a patient with Roux-en-Y anatomy
Authors: Hiroshi Kawakami, Yoshimasa Kubota, Shuhei Kawahata, Kimitoshi Kubo, Shinji Okabayashi, Ryoji Tatsumi, Naoya Sakamoto
Journal: Endoscopy (2016)

Endoscopic ultrasonography (EUS)-guided antegrade bile duct stone treatment has been developed for patients with altered anatomy [1] [2] [3] [4] [5]. Here, we present a case of successful bile duct stone treatment via an EUS-guided hepaticogastrostomy (EUS-HGS) route in the setting of prior Roux-en-Y reconstruction. Direct peroral transhepatic cholangioscopy-guided electronic hydraulic lithotripsy (EHL) and endoscopic papillary large-balloon dilation (EPLBD) were used.
Case 9-1989
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Barry L. Fanburg, Eugene J. Mark
Journal: New England Journal of Medicine (1989)

Presentation of CaseA 32-year-old man was admitted to the hospital because of the acquired immunodeficiency syndrome (AIDS), dyspnea, substernal pain, and an apparent cavitary lesion in the right lung.The patient was a practicing homosexual with a history of documented AIDS 15 months earlier. During the succeeding months he had several bouts of Pneumocystis carinii pneumonia, with the most recent episode occurring four months before entry. X-ray films of the chest (Fig. 1) that were obtained on that occasion showed diffuse linear and ground-glass opacities in both lungs; no hilar lymphadenopathy, pleural effusion, or cardiomegaly was seen. Because of . . .
Association of Vitamin B<sub>12</sub>, Folate, and Sulfur Amino Acids With Brain Magnetic Resonance Imaging Measures in Older Adults
Authors: Babak Hooshmand, Francesca Mangialasche, Grégoria Kalpouzos, Alina Solomon, Ingemar Kåreholt, A David Smith, Helga Refsum, Rui Wang, Marc Mühlmann, Birgit Ertl-Wagner, Erika Jonsson Laukka, Lars Bäckman, Laura Fratiglioni, Miia Kivipelto
Journal: JAMA Psychiatry (2016)

Vitamin B12, folate, and sulfur amino acids may be modifiable risk factors for structural brain changes that precede clinical dementia.To investigate the association of circulating levels of vitamin B12, red blood cell folate, and sulfur amino acids with the rate of total brain volume loss and the change in white matter hyperintensity volume as measured by fluid-attenuated inversion recovery in older adults.The magnetic resonance imaging subsample of the Swedish National Study on Aging and Care in Kungsholmen, a population-based longitudinal study in Stockholm, Sweden, was conducted in 501 participants aged 60 years or older who were free of dementia at baseline. A total of 299 participants underwent repeated structural brain magnetic resonance imaging scans from September 17, 2001, to December 17, 2009.The rate of brain tissue volume loss and the progression of total white matter hyperintensity volume.In the multi-adjusted linear mixed models, among 501 participants (300 women [59.9%]; mean [SD] age, 70.9 [9.1] years), higher baseline vitamin B12 and holotranscobalamin levels were associated with a decreased rate of total brain volume loss during the study period: for each increase of 1 SD, β (SE) was 0.048 (0.013) for vitamin B12 (P < .001) and 0.040 (0.013) for holotranscobalamin (P = .002). Increased total homocysteine levels were associated with faster rates of total brain volume loss in the whole sample (β [SE] per 1-SD increase, -0.035 [0.015]; P = .02) and with the progression of white matter hyperintensity among participants with systolic blood pressure greater than 140 mm Hg (β [SE] per 1-SD increase, 0.000019 [0.00001]; P = .047). No longitudinal associations were found for red blood cell folate and other sulfur amino acids.This study suggests that both vitamin B12 and total homocysteine concentrations may be related to accelerated aging of the brain. Randomized clinical trials are needed to determine the importance of vitamin B12 supplementation on slowing brain aging in older adults.
PTU-056 5-asa use in crohn’s remains common and is an opportunity for cost saving
Authors: A Zacks, EL Johnston, S Mashari, S Anderson, JD Sanderson, PM Irving
Journal: Gut (2015)

<h3>Introduction</h3> The British Society of Gastroenterology,<sup>1</sup>National Institute for Health and Care Excellence,<sup>2</sup>European Crohn’s and Colitis Organisation<sup>3</sup>and the American College of Gastroenterology,<sup>4</sup>agree that there is a limited role for 5-aminosalicylic acid (5-ASA) in the treatment of Crohn’s disease (CD). Despite this, many patients with CD are still prescribed 5-ASA regularly. <h3>Method</h3> 100 patients with CD were questioned about 5-ASA usage during routine outpatient appointments. They were asked whether they were prescribed a 5-ASA, if it was on repeat prescription, if they took it regularly or reserved it for flare-ups, and whether they perceived benefit from the drug. Finally, the consulting clinician made a clinical decision as to whether discontinuation of 5-ASA was appropriate. <h3>Results</h3> Of the 100 patients who were surveyed, 35 (35%) were taking a 5-ASA, 18 of whom (51%) were taking Pentasa, 11 (31%) Asacol, 4 (11%) Mezavant and the remaining two (6%) were uncertain which preparation they were taking. Of patients on 5-ASA, 3 (9%) were also on biologics, 4 (11%) were on immunomodulators (IM) and 6 (17%) were on a combination of IM and biologics. Of the 35 patients taking a 5-ASA, 20 (57.1%) were identified as candidates for cessation of treatment having taken into account patient opinion and concomitant medication as well as disease severity, site and extent. Based on current pricing, the projected annual saving for stopping 5-ASA’s in this cohort was £12,461. <h3>Conclusion</h3> Despite 5-ASA’s no longer being recommended for the treatment of CD, 35% of patients in our cohort were taking these medications. Annual projected cost savings across our local population (Southwark and Lambeth) are £332,470. <h3>Disclosure of interest</h3> A. Zacks Consultant for: Teva UK Limited, E. Johnston: None Declared, S. Mashari: None Declared, S. Anderson: None Declared, J. Sanderson: None Declared, P. Irving Speaker Bureau of: Warner Chilcott, Ferring, Shire, Tillott’s <h3>References</h3> Mowat. Guidelines for the management of inflammatory bowel disease in adults. <i>Gut</i>2011;<b>60</b>:571–607 National Institute for Health and Clinical Excellence. <i>Crohn’s disease, management in adults, children and young people</i>. London: NICE, 2012 Dignass A. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: current management. J Crohn’s Colitis 2010;4:28–62 Lichtenstein R. Management of Crohn’s disease in adults. Am J Gastroenterol 2009
Added Value of Female-Specific Factors Beyond Traditional Predictors for Future Cardiovascular Disease
Authors: Manon G. van der Meer, Yolanda van der Graaf, Ewoud Schuit, Linda M. Peelen, W.M. Monique Verschuren, Jolanda M.A. Boer, Karel G.M. Moons, Hendrik M. Nathoe, Yolande Appelman, Yvonne T. van der Schouw
Journal: Journal of the American College of Cardiology (2016)
The Effect of Riboflavine on the Metabolism of 2-Acetylaminofluorene-9-C&lt;sup&gt;14&lt;/sup&gt; in Rats&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: John H. Weisburger, Elizabeth K. Weisburger, Harold P. Morris
Journal: JNCI Journal of the National Cancer Institute (1954)

The Effect of Riboflavine on the Metabolism of 2-Acetylaminofluorene-9-C14 in Rats Get access John H. Weisburger, John H. Weisburger National Cancer Institute4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Elizabeth K. Weisburger, Elizabeth K. Weisburger National Cancer Institute4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold P. Morris Harold P. Morris National Cancer Institute4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 1, August 1954, Pages 37–47, https://doi.org/10.1093/jnci/15.1.37 Published: 01 August 1954 Article history Received: 08 February 1954 Published: 01 August 1954
The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment
Authors: Jiezuan Yang, Guoping Sheng, Dangsheng Xiao, Haiyan Shi, Wei Wu, Haifeng Lu, Hongcui Cao, Lanjuan Li
Journal: Cellular and Molecular Immunology (2016)
Quantification of BCR-ABL with Digital PCR Results in a Significantly Lower Rate of Deep Molecular Responses When Compared to RT-qPCR in CML Patients Treated in the ENEST1st Trial
Authors: Georg-Nikolaus Franke, Jacqueline Maier, Kathrin Wildenberger, Michael Cross, Oliver Frank, Frank Giles, Andreas Hochhaus, Christian T. Dietz, Martin C. Müller, Dietger Niederwieser, Thoralf Lange
Journal: Blood (2015)
Abstract 20180: Reduced Subendocardial Perfusion Correlates with Impaired Energy Supply-Demand Relations in Patients with Non-Ischemic Dilated Cardiomyopathy.
Authors: Susan P Bell, Douglas W Adkisson, Henry Ooi, Jeffrey M Dendy, Douglas B Sawyer, Mark A Lawson, Marvin W Kronenberg
Journal: Circulation (2010)

Introduction: Myocardial energy starvation is thought to be important in the pathophysiology of congestive heart failure. We previously reported impaired subendocardial perfusion reserve in humans ...
TCTAP A-135 Physiological Characteristics of Discordance Between Fractional Flow Reserve and Instantaneous Wave-Free Ratio
Authors: Doyeon Hwang, Joo Myung Lee, Jonghanne Park, Yaliang Tong, Jung-Kyu Han, Han-Mo Yang, Bon-Kwon Koo, Hyo-Soo Kim
Journal: Journal of the American College of Cardiology (2016)
The ANTIBIOPERF study: a nationwide cross-sectional survey about practices for β-lactam administration and therapeutic drug monitoring among critically ill patients in France
Authors: A. Charmillon, E. Novy, N. Agrinier, M. Leone, A. Kimmoun, B. Levy, B. Demoré, J. Dellamonica, C. Pulcini
Journal: Clinical Microbiology and Infection (2016)
Food and Drug Administration Approval for Use of Hiberix as a 3-Dose Primary<i>Haemophilus influenzae</i>Type b (Hib) Vaccination Series
Authors: Elizabeth C. Briere
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

On January 14, 2016, GlaxoSmithKline Biologicals (Research Triangle Park, North Carolina) received approval from the Food and Drug Administration (FDA) to expand use of Hiberix (Haemophilus b Conjugate Vaccine [Tetanus Toxoid Conjugate]) for a 3-dose infant primary vaccination series at ages 2, 4, and 6 months. Hiberix was first licensed in the United States in August 2009 for use as a booster dose in children aged 15 months through 4 years under the Accelerated Approval Regulations, in response to a Haemophilus influenzae type b (Hib) vaccine shortage that lasted from December 2007 to July 2009 (1). Expanding the age indication to include infants provides another vaccine option in addition to other currently licensed monovalent or combination Hib vaccines recommended for the primary vaccination series.* Hiberix contains 10 μg purified capsular polyribosyl ribitolphosphate (PRP) conjugated to 25 μg tetanus toxoid (PRP-T) and is supplied as a single-dose vial of lyophilized vaccine to be reconstituted with saline diluent. For the 3-dose primary series, a single (0.5 mL) dose should be given by intramuscular injection at ages 2, 4, and 6 months; the first dose may be given as early as age 6 weeks. The recommended catch-up schedule for PRP-T vaccines (http://www.cdc.gov/vaccines/schedules/hcp/child-adolescent.html) should be followed. As previously recommended, a single booster dose should be administered to children aged 15 months through 18 months; to facilitate timely booster vaccination, Hiberix can be administered as early as age 12 months, in accordance with Hib vaccination schedules for routine and catch-up immunization (1-3).
A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation
Authors: Daniel F. Aubert, Hao Xu, Jieling Yang, Xuyan Shi, Wenqing Gao, Lin Li, Fabiana Bisaro, She Chen, Miguel A. Valvano, Feng Shao
Journal: Cell Host & Microbe (2016)
Soundings: Au naturelle
Authors: Liam Farrell
Journal: BMJ (2005)

“I don't want any drugs,” she said, “I'd like something natural.”

The term “natural” is a broad and much abused church. In terms of Things GPs Don't Like To Hear, it's right up there with “He's pulling at his ears.” It refers to the material world and to those phenomena that function independently of humans, but somewhere along the line it became hijacked by the marketing men into a Sunday feature magazine bourgeois conceit: shampoos with “natural” spices, skin creams with miraculously anti-ageing “natural” herbs, “natural” products evangelically and uncritically feted as remedies for every conceivable complaint, with attractive exotic names like black hellebore, ginkgo biloba. It's even better if they come from the rain forest—endangered rainforest is best, especially if it has dolphins in it.

In the latter mode “natural” really means “completely untested, bugger all use, but probably safe and nicely expensive and a good earner for some crafty sod.” Strangely, people who have to live in the rain forest would prefer to have antibiotics and vaccines and maybe some antifungal creams for those eternally sweaty armpits and groins.

Heroin is natural, as is phlegm, and vomiting and diarrhoea. If we left it up to nature, life would be nasty, brutish, and short; as hunter gatherers we rarely lived to be 40, infant mortality was at least 250 per 1000 births, and half of us were dead by 5 years of age. We also had no TV.

On the positive side of this pre-Raphaelite fairytale existence, there were no worries about the side effects of hormone replacement therapy because the menopause was nature's way of telling us we were mouldy and obsolete and to make room for the young and good looking. Lifestyle changes were not an issue because we didn't live long enough to get cancers and heart disease (we could have smoked our brains out in those days, no problem).

Nature is not cuddly and benevolent; it is cold and unfeeling and surrenders its charms grudgingly, and any concessions have been wrested from it only by thousands of years of painstaking effort laced with occasional flashes of genius, often in the face of prejudice and persecution, thumbscrews, and iron maidens.

“Well,” I replied, “we could always just do nothing and let you die; it doesn't come any more natural than that.”
Fas/APO-1 (CD95)–Mediated Apoptosis Is Activated by Interferon-γ and Interferon- in Interleukin-6 (IL-6)–Dependent and IL-6–Independent Multiple Myeloma Cell Lines
Authors: Helena Spets, Patrik Georgii-Hemming, Jan Siljason, Kenneth Nilsson, Helena Jernberg-Wiklund
Journal: Blood (1998)
Hypothalamic pathology in the neuroleptic malignant syndrome
Authors: E Horn, B Lach, Y Lapierre, P Hrdina
Journal: American Journal of Psychiatry (1988)

The pathogenesis of the neuroleptic malignant syndrome is currently unclear, and no specific morphological abnormalities in the CNS of victims of neuroleptic malignant syndrome have been described. The authors report a case of neuroleptic malignant syndrome with recent foci of necrosis in the anterior and lateral hypothalamic nuclei. They discuss the role of tricyclic antidepressants, monoamine oxidase inhibitors, and neuroleptics in the development of this syndrome. They conclude that although the pathogenesis of the neuroleptic malignant syndrome is still not clear, necrosis of the hypothalamic nuclei may be pathognomonic for this syndrome.
Abstract 12590: A Multi-center Comparison of Established and Emerging Cardiac Biomarkers for the Diagnostic Evaluation of Chest Pain in the Emergency Department.
Authors: Anju Bhardwaj, W Frank Peacock, Kiang-Teck J Yeo, Alan Storrow, Quynh Truong, Stephen Thomas, Kevin M Curtis, Robert S Foote, Hong K Lee, Karen F Miller, James L Januzzi
Journal: Circulation (2010)

Introduction:  Prompt and accurate diagnostic evaluation of chest pain patients in the Emergency Department (ED) remains a challenge. We evaluated an array of established and emerging cardiac biomarkers for acute coronary syndrome (ACS) among patients with chest discomfort.   Methods:  Among patients presenting to the ED with symptoms suggestive of ACS, we compared first-draw results of cardiac troponin (cTnT), amino-terminal pro-B type natriuretic peptide (NT-proBNP), ischemia modified albumin (IMA; Inverness Medical Innovations), heart fatty acid binding protein (H-FABP; Hycult Technologies), high sensitivity troponin (hsTnI; Singulex, Inc) and free fatty acids (FFA; FFA Sciences). The value of each marker for ACS diagnosis/exclusion was determined using C-statistic, net reclassification improvement (NRI) and integrated discrimination improvement (IDI) analyses.   Results:  318 patients (mean age = 58 years; 53% male) were studied; 62 (19.5%) had a final diagnosis of ACS, of whom 40 had unstable angina. Neither IMA nor H-FABP detected or excluded ACS. A statistically significant increase in the cTnT C-statistic of 0.60 was seen with the addition of NT-proBNP (change = 0.09; P =.001), hsTnI (change = 0.13; P    Conclusions:  Among ED patients with symptoms suggestive of ACS, results for NT-proBNP, hsTnI or FFA added diagnostic information to cTnT. In the context of hsTnI results, FFA measurement significantly reclassified both false negatives and false positives.
Exosomes Secreted By Multiple Myeloma Cell Lines (MMCLs) and Bone Marrow Stromal Cells (BMSCs) Reciprocally Modulate Cell Adhesion and Impact on MM Cell Migration and Bortezomib-Induced Apoptosis
Authors: Josefina Udi, Reinhard Voll, Daniela Ureta, Margarita López, Ralph Wäsch, Élida Álvarez, Monika Engelhardt
Journal: Blood (2014)
The Search for a Crystal Ball to Predict Early Recovery From Peripartum Cardiomyopathy? ∗
Authors: Uri Elkayam, Ofer Habakuk
Journal: JACC Heart Failure (2016)

Peripartum cardiomyopathy (PPCM) is an idiopathic myocardial disease presenting toward the end of pregnancy or in the months following delivery with heart failure secondary to left ventricular (LV) systolic dysfunction [(1)][1]. Left ventricular ejection fraction (LVEF) at diagnosis is usually
TCTAP A-011 Influence of Microvascular Dysfunction on Regional Myocardial Deformation in the Sub-Acute Phase of Myocardial Infarction: A Pilot Study Comparing Angiographically Defined Microvascular Dysfunction with Speckle-Tracking Echocardiography Assessed Myocardial Deformation
Authors: Song Ding, Zhiqing Qiao, Jun Pu, Ben He
Journal: Journal of the American College of Cardiology (2016)
Active Surveillance and Isolation of Asymptomatic Carriers of<i>Clostridium difficile</i>at Hospital Admission
Authors: Alice Y. Guh, L. Clifford McDonald
Journal: JAMA Internal Medicine (2016)

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Endoscopic treatment of colonic diverticular bleeding using an over-the-scope clip
Authors: Andreas Probst, Georg Braun, Stefan Goelder, Helmut Messmann
Journal: Endoscopy (2016)

A 73-year-old woman who was receiving dual antiplatelet therapy (acetylsalicylic acid and prasugrel) after coronary stenting presented with severe hematochezia. Immediate colonoscopy without bowel preparation, using a CF-HQ190I colonoscope (Olympus Medical Systems, Tokyo, Japan) with a transparent cap (D-201-14304, Olympus), revealed active and sustained bleeding from a diverticulum in the sigmoid colon ([Fig. 1 a]).