tbuckley/cabot-search huggingface dataset:
Radiological Image Traits Predictive of Cancer Status in Pulmonary Nodules
Authors: Ying Liu, Yoganand Balagurunathan, Thomas Atwater, Sanja Antic, Qian Li, Ronald C. Walker, Gary T. Smith, Pierre P. Massion, Matthew B. Schabath, Robert J. Gillies
Journal: Clinical Cancer Research (2016)

Purpose: We propose a systematic methodology to quantify incidentally identified pulmonary nodules based on observed radiological traits (semantics) quantified on a point scale and a machine-learning method using these data to predict cancer status.Experimental Design: We investigated 172 patients who had low-dose CT images, with 102 and 70 patients grouped into training and validation cohorts, respectively. On the images, 24 radiological traits were systematically scored and a linear classifier was built to relate the traits to malignant status. The model was formed both with and without size descriptors to remove bias due to nodule size. The multivariate pairs formed on the training set were tested on an independent validation data set to evaluate their performance.Results: The best 4-feature set that included a size measurement (set 1), was short axis, contour, concavity, and texture, which had an area under the receiver operator characteristic curve (AUROC) of 0.88 (accuracy = 81%, sensitivity = 76.2%, specificity = 91.7%). If size measures were excluded, the four best features (set 2) were location, fissure attachment, lobulation, and spiculation, which had an AUROC of 0.83 (accuracy = 73.2%, sensitivity = 73.8%, specificity = 81.7%) in predicting malignancy in primary nodules. The validation test AUROC was 0.8 (accuracy = 74.3%, sensitivity = 66.7%, specificity = 75.6%) and 0.74 (accuracy = 71.4%, sensitivity = 61.9%, specificity = 75.5%) for sets 1 and 2, respectively.Conclusions: Radiological image traits are useful in predicting malignancy in lung nodules. These semantic traits can be used in combination with size-based measures to enhance prediction accuracy and reduce false-positives. Clin Cancer Res; 23(6); 1442-9. ©2016 AACR.
Follicular Lymphoma Cell Niche: Identification of a Preeminent IL-4-Dependent TFH- B Cell Axis.
Authors: Karin Tarte, Pangault Celine, Patricia Ame-Thomas, Philippe Ruminy, Delphine Rossille, Gersende Caron, Maryse Bahia, John De Vos, Mikael Roussel, Celine Monvoisin, Thierry Lamy, Philippe Gaulard, Herve Tilly, Thierry Fest
Journal: Blood (2009)
Allogeneic Stem-Cell Transplantation for Patients with De Novo Acute Myeloid Leukemia Not in Complete Response: Results of a Survey from the European Group for Blood and Bone Marrow Transplantation (EBMT).
Authors: Jordi Esteve, Myriam Labopin, Jurgen Finke, Athanasios Fassas, Catherine Cordonnier, Axel Arthur Fauser, Mauricette Michallet, Francesco Frassoni, Nicholas Harhalakis, Jossy Reiffers, E. Paolo Alessandrino, Gerhard Ehninger, Norbert C. Gorin, Vanderson Rocha
Journal: Blood (2004)
Treatment of HCV Genotype 2 with Sofosbuvir and Ribavirin Results in Low SVR Rates ina Real World Cohort (German Hepatitis C-Registry, DHC-R)
Authors: F. Tacke, R. Günther, P. Buggisch, H. Klinker, A. Schober, C. John, T. Lutz, H. Pfeiffer-Vornkahl, C. Niederau, M. Cornberg, C. Sarrazin, S. Mauss
Journal: Journal of Hepatology (2016)
Risk of second cancers among a cohort of 2,703 long-term survivors of testicular seminoma treated with radiotherapy.
Authors: A. Horwich, S. D. Fossa, S. P. Stenning, J. M. Bliss, E. Hall
Journal: Journal of Clinical Oncology (2010)

4538 Background: Stage 1 testicular seminoma has been treated by only orchidectomy and adjuvant infradiaphragmatic radiotherapy for the last half-century, occurs in early adult life and has an excellent prognosis, thus permitting the analysis of radiation carcinogenesis. Methods: A cohort of 2703 survivors of stage 1 seminoma treated with infradiaphragmatic radiotherapy from the UK and Norway were identified from radiotherapy center records and then matched to individual national cancer registry data to determine incidence of subsequent cancers. The identification of subjects from treatment records enabled investigation of dose and field size effects with more precision than previous epidemiological studies based on cancer registry data alone. The primary endpoint was number of non-testis second cancers (excluding non-melanoma skin cancers). Specific second cancers were analysed of sites related to the standard radiotherapy field. Person years of observation (PY) were compiled by age and calendar periods from 3 months after the end of radiotherapy to date of diagnosis of second cancer. Patients were censored at death or at 31/12/2005 (Norwegian patients) or 31/12/2007 ( UK patients). Cancer incidence rates specific for country, age, sex, and 5-year calendar period were used to determine expected number of cancers and standardised incidence ratios (SIR) based on assumption of a Poisson distribution. SIRs were analysed with respect to RT parameters i.e. dose, field and machine type. Results: Median follow up was 18.0 years (IQR 8.6-23.7 years); total PYs at risk was > 53,600 during which 385 second cancers were reported in 354 men. The excess of second cancers in long-term survivors was statistically significant (SIR 1.31; 95% CI 1.19-1.45). Sites with statistically significant excess risk were stomach (SIR 1.63; 95% CI 1.08-2.45), pancreas (SIR 2.35; 95%CI 1.52-3.64) and bladder (SIR; 2.14 95%CI 1.58-2.88). Conclusions: Infradiaphragmatic radiotherapy is associated with a significant excess of second cancers; policies for treating stage 1 seminoma should be revised. No significant financial relationships to disclose.
When “Actionable” Genomic Sequencing Results Cannot Be Acted Upon
Authors: Brian J. Zikmund-Fisher
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
High Prognostic Impact of Flowcytometric Minimal Residual Disease Detection In Acute Myeloid Leukemia: Prospective Data From the HOVON/SAKK 42a Study
Authors: Monique Terwijn, Angèle Kelder, Wim L.J. van Putten, Alexander N. Snel, Vincent H.J. van der elden, Rik A. Brooimans, Nancy Boeckx, Frank W.M.B. Preijers, Bob Löwenberg, Angelika M. Dräger, Peter C. Huijgens, Peter J.M Valk, Johan Maertens, Thomas Pabst, Gert J. Ossenkoppele, Gerrit J. Schuurhuis
Journal: Blood (2010)
D-tryptophan from probiotic bacteria influences the gut microbiome and allergic airway disease
Authors: Inge Kepert, Juliano Fonseca, Constanze Müller, Katrin Milger, Kerstin Hochwind, Matea Kostric, Maria Fedoseeva, Caspar Ohnmacht, Stefan Dehmel, Petra Nathan, Sabine Bartel, Oliver Eickelberg, Michael Schloter, Anton Hartmann, Philippe Schmitt-Kopplin, Susanne Krauss-Etschmann
Journal: Journal of Allergy and Clinical Immunology (2016)
Unmet Needs for Ancillary Services Among Men Who Have Sex with Men and Who Are Receiving HIV Medical Care — United States, 2013–2014
Authors: Nicholas P. DeGroote, Lauren C. Korhonen, R. Luke Shouse, Linda A. Valleroy, Heather Bradley
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Gay, bisexual, and other men who have sex with men (MSM) are disproportionately affected by human immunodeficiency virus (HIV) in the United States (1). Ancillary services, defined as services that support retention in HIV medical care and assist with day-to-day living, can improve the health of HIV-infected MSM and help them achieve viral suppression (2). To assess the unmet needs for ancillary services among MSM receiving outpatient HIV medical care during 2013-2014, CDC used data from the Medical Monitoring Project (MMP), a surveillance system designed to assess clinical and behavioral characteristics of adults receiving HIV care, to obtain nationally representative estimates of, and identify reasons for, unmet needs (3). Based on self-reported needs of persons responding to the MMP survey, the most prevalent unmet needs were for non-HIV medical care services: approximately 23% had an unmet need for dental care, and 19% had an unmet need for eye or vision care. Unmet needs were most prevalent among young, non-Hispanic black, and Hispanic/Latino MSM. State and local health departments, community-based organizations, and health care providers might improve the health of MSM living with HIV by promoting access to ancillary services using strategies that increase patient awareness of how to obtain these services, especially among young, non-Hispanic black, and Hispanic/Latino MSM.
Surgeon’s comments about Asian colleagues were rude but not racist, tribunal says
Authors: Clare Dyer
Journal: BMJ (2016)

A senior surgeon and clinical director who spoke harshly about a group of doctors from India and Pakistan in front of other staff was rude but not racist and was not guilty of serious misconduct, a medical practitioners tribunal has found.

Peter Hale, 58, a consultant surgeon with an interest in gastroenterology, was referred to the General Medical Council by four doctors of Pakistani and Indian origin who said that he used racist and derogatory language about them after they left a 2013 meeting at which they had argued with him over contracts and rotas, accusing him of racism and “slavery.”

“Some of these sub-continent elements—what you end up with is long term resentments,” Hale …
Applicability of Dried Blood Samples for Hepatitis C Virus Detection and Quantification
Authors: L.M. Villar, B.L.C. Marques, M.P. Espírito-Santos, V.A. Marques, C.A. Villela-Nogueira, L.L. Lewis-Ximenez, E. Lampe
Journal: Journal of Hepatology (2016)
Combined Analysis of Three Large Interventional Trials With Gliptins Indicates Increased Incidence of Acute Pancreatitis in Patients With Type 2 Diabetes
Authors: Ivan Tkáč, Itamar Raz
Journal: Diabetes Care (2016)

OBJECTIVE Data on the possible relationship of gliptin treatment with the incidence of acute pancreatitis have been controversial. The aim of the current study was to combine data on the incidence of acute pancreatitis from three large randomized controlled trials. RESEARCH DESIGN AND METHODS Three trials designed to test cardiovascular safety and efficacy of add-on treatment with a gliptin were included in the analysis, as follows: SAVOR-TIMI 53 (saxagliptin), EXAMINE (alogliptin), and TECOS (sitagliptin). The trials included 18,238 gliptin-treated patients and 18,157 placebo-treated patients. Data were combined using a random-effects model meta-analysis. RESULTS The incidence of acute pancreatitis was significantly increased in the gliptin-treated patients when compared with the control groups (odds ratio 1.79 [95% CI 1.13–2.82], P = 0.013). The difference in the absolute risk was small (0.13%). CONCLUSIONS Treatment with gliptins significantly increased the risk for acute pancreatitis in a combined analysis of three large controlled randomized trials.
The Impact of Local Air Quality on the Number of Hospital Admissions with Acute Pain in Sickle Cell Disease within an Urban Environment.
Authors: Deborah Yallop, Edward R. Duncan, Ellie Norris, Gary Fuller, Nikki Thomas, Joan Walters, Moira C. Dick, Susan E. Height, Swee Lay Thein, David C. Rees
Journal: Blood (2006)
The Common Prosteatotic PNPLA3 (Adiponutrin) p.I148M Variant Might Protect against Gallstone Disease
Authors: M. Krawczyk, R. Jiménez-Agüero, M.J. Perugorria, L. Gallego, L. Bujanda, F. Lammert, J.M. Banales
Journal: Journal of Hepatology (2016)
New onset atrial fibrillation following myocardial infarction is a strong independent predictor of mortality in patients treated with primary percutaneous coronary intervention
Authors: Renato D Lopes, Harvey D White, Judith Hochman, John R Horton, Frans Van de Werf, Diego Ardissino, Torsten T Nielsen, W. Douglas Weaver, Petr Widimsky, Paul W Armstrong, Christopher B Granger
Journal: Journal of the American College of Cardiology (2008)
Development and Validation of an On-Line Web Calculator for Survival after Trans-Arterial Chemo-Embolization for Hepatocellular Carcinoma
Authors: A. Cappelli, C. Sposito, F. Brunero, A. Cucchetti, G. Cabibbo, A. Facciorusso, J. Toti, R. Golfieri, V. Mazzaferro
Journal: Journal of Hepatology (2016)
Favorable Patient Survival after Failure of Venetoclax (ABT-199/ GDC-0199) Therapy for Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL)
Authors: Constantine Tam, Mary Ann Anderson, David S. Ritchie, E. Henry Januszewicz, Dennis Carney, Andrew W. Roberts, John F. Seymour
Journal: Blood (2015)
Reversal of Minimal Hepatic Encephalopathy aftera Probiotic Administration. A Prospective, Randomized, Placebo-Controlled, Double-Blind Study
Authors: J. Vlachogiannakos, P. Vasianopoulou, N. Viazis, M. Chroni, D. Karamanolis, S.D. Ladas
Journal: Journal of Hepatology (2016)
Impact of Histological Features of Hepatocellular Carcinoma on MTOR Pathway Expression after Liver Transplantation
Authors: M. Rodríguez-Perálvarez, M. Guerrero-Misas, G. Ferrín, L. Barrera, M. Sánchez-Frías, J.M. Álamo, R. Ciria, F. Serrano, C. Bernal, J. Briceño, M.Á. Gómez-Bravo, J.L. Montero, M. De la Mata
Journal: Journal of Hepatology (2016)
C-Edge Co-Star: Risk of Reinfection following Successful Therapy with Elbasvir and Grazoprevir in Persons who Inject Drugs (PWID) Receiving Opioid Agonist Therapy (OAT)
Authors: G. Dore, F. Altice, A.H. Litwin, J. Grebely, O. Dalgard, E.J. Gane, O. Shibolet, A. Luetkemeyer, R. Nahass, C.-Y. Peng, B. Conway, I.N. Gendrano, H.-C. Huang, E. Chen, B.-Y. Nguyen, J. Wahl, E. Barr, M. Robertson, H.L. Platt
Journal: Journal of Hepatology (2016)
Clinical Trial to Evaluate the Efficacy of Primary Prophylaxis with L-Ornithine L-Aspartate to Prevent the Development of Overt Hepatic Encephalopathy in Patients with Cirrhosis and Acute Variceal Bleeding
Authors: F. Higuera-de la Tijera, A.I. Servín-Caamaño, F. Salas-Gordillo, J.M. Abdo-Francis, J. Camacho-Aguilera, J.L. Pérez-Hernández, F. Jiménez-Ponce
Journal: Journal of Hepatology (2016)
Cytogenetic risk group and cytogenetic response predict outcome of patients with poor-risk mds and secondary aml treated with intensive chemotherapy and stem cell transplantation in a joint study (CRIANT) of the EORTC, EBMT, SAKK, HOVON and GIMEMA leukemia groups
Authors: T de Witte, Anne Hagemeijer-Hausman, S Suciu, Michel Delforge, M Jotterand-bellomo, I Tigaud, A Belhabri, C Aul, M Avaido, D Selleslag, H Schouten, A Ferrant, S Amadori, P Muus, O Anak, F Beeldens, J Janden, E Hellstrom-Lindberg, A Gratwohl, R Willemze
Journal: Blood (2001)
Acid Sphingomyelinase Targeting Reduces the Progression of Diet-Induced Non-Alcoholic Steatohepatitis in Mice with Disrupted Methionine Homeostasis
Authors: C. Alarcon, A. Baulies, V. Ribas, J.M. Mato, S. Núñez, J. Caballeria, C. Garcia-Ruiz, J.C. Fernandez-Checa
Journal: Journal of Hepatology (2016)
P0793 : Estimating the number of chronic hepatitis C patients in need of treatment and projecting the disease burden during 2015–2030 under the interferon-free treatment regimens in Greece
Authors: V. Sypsa, I. Gountas, G. Papatheodoridis, K. Souliotis, H. Razavi, A. Hatzakis
Journal: Journal of Hepatology (2015)
Vasectomy is not linked to raised risk of prostate cancer, study finds
Authors: Susan Mayor
Journal: BMJ (2016)

Men who have a vasectomy show no increased risk of developing or dying from prostate cancer, two large US cohort studies have shown.1

A previous prospective study suggested a 10% increased risk of prostate cancer with vasectomy and an even higher risk of high grade and lethal prostate cancer,2 but other studies have shown no association.

The new studies, published in the Journal of Clinical Oncology , looked …
Fibrotic Burden, Not Antiviral Agent, Determines Clinical Outcome in Chronic Hepatitis B Patients: A Propensity-Score Matched Analysis
Authors: H.S. Kim, B.K. Kim, S.U. Kim, J.Y. Park, D.Y. Kim, S.H. Ahn, K.J. Song, J. Won Park, Y.J. Kim, O. Baatarkhuu, K.H. Han
Journal: Journal of Hepatology (2016)
In vitro potency, in vitro and in vivo efficacy of liposomal alendronate in combination with γδ T cell immunotherapy in mice
Authors: Naomi O. Hodgins, Wafa' T. Al-Jamal, Julie T-W. Wang, Ana C. Parente-Pereira, Mao Liu, John Maher, Khuloud T. Al-Jamal
Journal: Journal of Controlled Release (2016)

Nitrogen-containing bisphosphonates (N-BP), including zoledronic acid (ZOL) and alendronate (ALD), have been proposed as sensitisers in γδ T cell immunotherapy in pre-clinical and clinical studies. Therapeutic efficacy of N-BPs is hampered by their rapid renal excretion and high affinity for bone. Liposomal formulations of N-BP have been proposed to improve accumulation in solid tumours. Liposomal ALD (L-ALD) has been suggested as a suitable alternative to liposomal ZOL (L-ZOL), due to unexpected mice death experienced in pre-clinical studies with the latter. Only one study so far has proven the therapeutic efficacy of L-ALD, in combination with γδ T cell immunotherapy, after intraperitoneal administration of γδ T cell resulting in delayed growth of ovarian cancer in mice. This study aims to assess the in vitro efficacy of L-ALD, in combination with γδ T cell immunotherapy, in a range of cancerous cell lines, using L-ZOL as a comparator. The therapeutic efficacy was tested in a pseudo-metastatic lung mouse model, following intravenous injection of γδ T cell, L-ALD or the combination. In vivo biocompatibility and organ biodistribution studies of L-N-BPs were undertaken simultaneously. Higher concentrations of L-ALD (40–60 μM) than L-ZOL (3–10 μM) were required to produce a comparative reduction in cell viability in vitro, when used in combination with γδ T cells. Significant inhibition of tumour growth was observed after treatment with both L-ALD and γδ T cells in pseudo-metastatic lung melanoma tumour-bearing mice after tail vein injection of both treatments, suggesting that therapeutically relevant concentrations of L-ALD and γδ T cell could be achieved in the tumour sites, resulting in significant delay in tumour growth.
Impact of FLT3 Mutational Status as Prognostic Factor in Acute Myeloid Leukemia Patients from Argentina and Uruguay.
Authors: Isabel Giere, Angel Chacon, Rosario Uriarte, Virginia Lombardi, Isolda Fernandez, Fernanda Garcia Reinoso, Rosana Bonomi, Maria Zubillaga, Hugo Giordano, Laura Pardo, Sandra Sapia, Mariela Monreal, Lem Martinez, Santiago Pavlovsky
Journal: Blood (2005)
Co-Administration of Chimpanzee Adenoviral Vectors of Different Serotypes, for the Prevention of HCV and HIV Co-Infection
Authors: F. Hartnell, A. Brown, E. Ghaffari, B. Turner, A. Folgori, S. Capone, A. Nicosia, R. Cortese, S. Colloca, T. Hanke, L. Dorrell, E. Barnes
Journal: Journal of Hepatology (2016)
HDAC8 Overexpression in Mesenchymal Stromal Cells from JAK2+ myeloproliferative Neoplasms: A New Therapeutic Target?
Authors: Teresa L. Ramos, Luis Ignacio Sánchez-Abarca, Rosón Beatriz, Concepción Rodríguez Serrano, Alba Redondo, Rebeca Ortega, Ángel Hernández-Hernández, Sandra Muntión, Silvia Preciado, José Ramón González-Porras, Fermín Sánchez-Guijo, Consuelo Del CaÃ±izo
Journal: Blood (2015)
Postgrafting Immune Suppression Combined with Nonmyeloablative Conditioning for Transplantation of HLA-Identical Hematopoietic Cell Grafts: Results of a Phase I Study for Treatment of Immunodeficiency Disorders.
Authors: Lauri Burroughs, Rainer F. Storb, Wendy Leisenring, Michael Pulsipher, Michael R. Loken, Troy Torgerson, Hans D. Ochs, Ann Woolfrey
Journal: Blood (2005)
Systems Strategies for Health Throughout the Life Course
Authors: J. Michael McGinnis, Angela Diaz, Neal Halfon
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pemetrexed plus cisplatin (P plus CIS) or carboplatin (P plus CB) in chemonaive malignant pleural mesothelioma (MPM) patients (PTS): Results of the international expanded access program (EAP)
Authors: A Santoro, P. A Zucali, M O'Brien, R Stahel, Kristiaan Nackaerts, P Baas, L Paz-Ares, S Sundstrom, J Blatter, C Manegold
Journal: Annals of Oncology (2007)
Generation and Application of a CML-Specific Recombinant Adeno-Associated Virus (rAAV) Vector.
Authors: Marius Stiefelhagen, Marlon R. Veldwijk, Anna Jauch, Volker Eckstein, Stephanie Laufs, Juergen A. Kleinschmidt, Frederik Wenz, Jens W. Zeller, Anthony D. Ho, Stefan Fruehauf
Journal: Blood (2005)