tbuckley/cabot-search huggingface dataset:
Creation and implementation of SAMPRO™: A school-based asthma management program
Authors: Robert F. Lemanske, Sujani Kakumanu, Kathleen Shanovich, Nicholas Antos, Michelle M. Cloutier, Donna Mazyck, Wanda Phipatanakul, Shirley Schantz, Stanley Szefler, Renee Vandlik, Paul Williams
Journal: Journal of Allergy and Clinical Immunology (2016)

Clinicians who care for children with asthma have an obligation to coordinate asthma care with the schools. Aside from routine clinical care of asthmatic children, providers must educate the family and child about the need for an asthma treatment plan in school and support the school nurse meeting the needs of the student requiring school-based asthma care. The following article was developed by multiple stakeholders to address this need. It describes the 4 components of the School-based Asthma Management Program (SAMPRO™). SAMPRO™ details elements necessary for the education of children, families, clinicians, and school-based personnel based on a "circle of support" that would enhance multidirectional communication and promote better care for children with asthma within the school setting.
Effect of Eltrombopag on Platelet Response and Safety Results in Chinese Adults with Chronic ITP-Primary Result of a Phase III Study
Authors: Renchi Yang, Ming Hou, Junmin Li, Jie Jin, Meijuan Huang, Ziqiang Yu, Xiaojun Xu, Xiaohui Zhang, Xin Du, Ting Niu, Xiaoyan Ke, Jianmin Wang, Jing Liu, Jing Sun, Yongqiang Zhao, Hua Lu, Haiyi Guo, Belinda Hsu
Journal: Blood (2014)
Omega-3 Fatty Acid Supplementation and Cardiovascular Disease Events
Authors: Claudio Galli, J. Thomas Brenna
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Intrinsically Disordered Region of the DNA Repair Protein Nbs1 Is a Species-Specific Barrier to Herpes Simplex Virus 1 in Primates
Authors: Dianne I. Lou, Eui Tae Kim, Nicholas R. Meyerson, Neha J. Pancholi, Kareem N. Mohni, David Enard, Dmitri A. Petrov, Sandra K. Weller, Matthew D. Weitzman, Sara L. Sawyer
Journal: Cell Host & Microbe (2016)
Evaluation of IL-6 level in serum and bronchoalveolar lavage fluid of patients with non-small cell lung cancer (NSCLC)
Authors: Marina Petrovic, Nevenka Ilic, Zorica Lazic, Ivan Cekerevac, Ljiljana Novkovic, Gordana Kostic, Vojislav Cupurdija
Journal: European Respiratory Journal (2011)

Aim:  To study the relationship between the interleukin-6 (IL-6) level in serum and broncheoalveolar lavage fluid (BALF) and non-small cell lung cancer (NSCLC).   Methods:  The concentration of IL-6 in serum or BALF of 82 NSCLC patients, 56 patients of pulmonary inflammatory diseases (PID) and 26 normal controls were measured by ELISA.   Results:  The concentration of IL-6 in BALF of NSCLC patients was significantly higher than that of PID patients and normal controls (P 0.05). Serum IL-6 level was higher in NSCLC of advanced stages (stage IIIa, IIIb and IV), as compared with that in NSCLC patients of early stages (stage Ia-IIb). BALF IL-6 level of NSCLC patients at different stages was not different. IL-6 (level in serum but not in BALF) of PID patients correlated with the serum concentration of C reactive protein (r=0.69).   Conclusion:  IL-6 in BALF might be used as a marker for NSCLC. Serum IL-6 level might be an indicator for the stage of NSCLC. The serum IL-6 can also reflect the severity of acute lung inflammatory response.
High burden of hospital resource utilization in patients with hidradenitis suppurativa in England: a retrospective cohort study using hospital episode statistics
Authors: N. Desai, P. Shah
Journal: British Journal of Dermatology (2016)

The health resource utilization associated with managing patients with hidradenitis suppurativa (HS) in England is unknown.To describe the characteristics of patients with HS and hospital resource use associated with management of HS in England.A retrospective cohort study using Hospital Episode Statistics data. Patients with a primary diagnostic code for HS (ICD-10 code L73·2) during an inpatient admission (n = 11 359) between 1 April 2007 and 31 December 2013 were identified; patients with code L73·2 attending only as outpatients were excluded. Data for all inpatient, outpatient and accident and emergency admissions during the study period were extracted.Of the 11 359 patients, 10 832 had a first recorded inpatient HS diagnostic code (index spell) during the study period (female 7569, 69·9%). The mean age at the index spell was 39 ± 13·1 years in men and 36 ± 11·7 years in women. There were 65 544 inpatient spells during the study period; 7202 (63·4%) patients underwent nonelective spells, 4128 (36.3%) elective spells and 9790 (86·2%) day-case attendances. There were 43 773 accident and emergency attendances during the study period in 8716 (76·7%) patients. There were 303 204 outpatient appointments in 11 203 patients (mean 27·1 per patient); 4827 (42·5%) of the study population attended dermatology, 8087 (71·2%) general surgery and 4111 (36·2%) plastic surgery. Based on the mean number of spells per patient per year, the mean hospital resource utilization cost for a patient with HS was £2027 per patient per year.HS is associated with a large burden of hospital attendances for young patients of working age and high National Health Service resource costs.
Toward mechanistic models of action-oriented and detached cognition
Authors: Giovanni Pezzulo
Journal: Behavioral and Brain Sciences (2016)

To be successful, the research agenda for a novel control view of cognition should foresee more detailed, computationally specified process models of cognitive operations including higher cognition. These models should cover all domains of cognition, including those cognitive abilities that can be characterized as online interactive loops and detached forms of cognition that depend on internally generated neuronal processing.
<i>TPL2</i> Is an Oncogenic Driver in Keratocanthoma and Squamous Cell Carcinoma
Authors: Jun-Han Lee, Joo-Hyung Lee, Sang Hyuk Lee, Sung-Im Do, Sung-Dae Cho, Ola Forslund, Kyung-Soo Inn, Jeong-Sang Lee, Fang-Ming Deng, Jonathan Melamed, Jae U. Jung, Joseph H. Jeong
Journal: Cancer Research (2016)

Abstract Squamous cell carcinoma (SCC) and keratoacanthoma (KA; SCC/KA) research has been hampered mainly by our lack of understanding the underlying genetic and epigenetic alterations associated with SCC/KA development, as well as the lack of animal models that faithfully recapitulate histopathologic features of human SCC/KA. Here, we show that TPL2 overexpression induced both cell transformation in immortalized human keratinocytes and SCC and KA-like cutaneous SCC (cSCC) development in mice. Mechanistically, activation of TPL2 downstream signaling pathways such as MEK/ERK MAPK, mTOR, NF-κB, and p38 MAPK leads to TPL2-mediated cell transformation in immortalized human keratinocytes and tumorigenesis in mice. Most importantly, TPL2 overexpression is required for iTPL2 TG–driven SCC and KA-like cSCC tumor maintenance, validating TPL2 as a possible drug target for the treatment of SCC/KA. Finally, we verified that TPL2 is overexpressed in human cutaneous metastatic SCC and KA clinical specimens compared with normal skin. Taken together, our results establish TPL2 as an oncogenic driver in SCC/KA development. Cancer Res; 76(22); 6712–22. ©2016 AACR.
Screening for Latent Tuberculosis Infection in Adults
Authors: Kirsten Bibbins-Domingo, David C. Grossman, Susan J. Curry, Linda Bauman, Karina W. Davidson, John W. Epling, Francisco A.R. García, Jessica Herzstein, Alex R. Kemper, Alex H. Krist, Ann E. Kurth, C. Seth Landefeld, Carol M. Mangione, William R. Phillips, Maureen G. Phipps, Michael P. Pignone
Journal: JAMA (2016)

<h3>Importance</h3> Tuberculosis remains an important preventable disease in the United States. An effective strategy for reducing the transmission, morbidity, and mortality of active disease is the identification and treatment of latent tuberculosis infection (LTBI) to prevent progression to active disease. <h3>Objective</h3> To issue a current US Preventive Services Task Force (USPSTF) recommendation on screening for LTBI. <h3>Evidence Review</h3> The USPSTF reviewed the evidence on screening for LTBI in asymptomatic adults seen in primary care, including evidence dating from the inception of searched databases. <h3>Findings</h3> The USPSTF found adequate evidence that accurate screening tests for LTBI are available, treatment of LTBI provides a moderate health benefit in preventing progression to active disease, and the harms of screening and treatment are small. The USPSTF has moderate certainty that screening for LTBI in persons at increased risk for infection provides a moderate net benefit. <h3>Conclusions and Recommendation</h3> The USPSTF recommends screening for LTBI in populations at increased risk. (B recommendation)
A Quantitative Comparison of Antibodies to Programmed Cell Death 1 Ligand 1
Authors: Patricia Gaule, James W. Smithy, Maria Toki, Jamaal Rehman, Farah Patell-Socha, Delphine Cougot, Philippe Collin, Paul Morrill, Veronique Neumeister, David L. Rimm
Journal: JAMA Oncology (2016)

Assessment of PD-L1 (programmed cell death 1 ligand 1) expression by immunohistochemical analysis has been used as a predictive diagnostic test to identify responders and guide treatment in trials of the PD-1 (programmed cell death 1) axis inhibitors. The definition of PD-L1 positive lacks standardization, and prediction of response by immunohistochemical analysis is additionally limited by the subjective nature of this technique.To examine whether PD-L1 antibody reagents are interchangeable by quantitatively comparing the expression of the PD-L1 protein.In this immunohistochemistry standardization study, 30 randomly selected cases of lung cancer resected from January 1, 2008, through December 31, 2009, were obtained from Yale Pathology Archives with a range of expression of PD-L1. To test for protein measurement, rather than clinical utility, a PD-L1 index tissue microarray, including cell line and tissue controls, was used. The results were then validated on a commercially available, genetically defined PD-L1 engineered cell line array with a range of controlled protein-expressing cell lines using 6 monoclonal antibodies (SP142, E1L3N, 9A11, SP263, 22c3, and 28-8). Protein levels were measured by quantitative immunofluorescence and quantitative chromogenic assessment. Data analysis was performed from September 2015 through May 2016.Concordance between 4 antibodies revealed regression for tumor tissue cores (R2 = 0.42-0.91) and cell line cores (R2 = 0.83-0.97) by quantitative immunofluorescence in the PD-L1 index tissue microarray. All 6 antibodies had high levels of concordance (R2 = 0.76-0.99) when using chromogenic staining in isogenic cell lines.Because the antibodies are highly concordant, these results suggest that assays based on the use of these antibodies could yield concordant results. They further suggest that previously described differences in PD-L1 expression in tissue are independent of the antibody used and likely attributable to tumor heterogeneity, assay- or platform-specific variables, or other factors.
Gene expression–based discovery of atovaquone as a STAT3 inhibitor and anticancer agent
Authors: Michael Xiang, Haesook Kim, Vincent T. Ho, Sarah R. Walker, Michal Bar-Natan, Melodi Anahtar, Suhu Liu, Patricia A. Toniolo, Yasmin Kroll, Nichole Jones, Zachary T. Giaccone, Lisa N. Heppler, Darwin Q. Ye, Jason J. Marineau, Daniel Shaw, James E. Bradner, Traci Blonquist, Donna Neuberg, Claudio Hetz, Richard M. Stone, Robert J. Soiffer, David A. Frank
Journal: Blood (2016)
National outbreak of Yersinia enterocolitica infections in military and civilian populations associated with consumption of mixed salad, Norway, 2014
Authors: Emily MacDonald, Margot Einöder-Moreno, Katrine Borgen, Lin Thorstensen Brandal, Lore Diab, Øivind Fossli, Bernardo Guzman Herrador, Ammar Ali Hassan, Gro S Johannessen, Eva Jeanette Johansen, Roger Jørgensen Kimo, Tore Lier, Bjørn Leif Paulsen, Rodica Popescu, Charlotte Tokle Schytte, Kristin Sæbø Pettersen, Line Vold, Øyvind Ørmen, Astrid Louise Wester, Marit Wiklund, Karin Nygård
Journal: Eurosurveillance (2016)

In May 2014, a cluster of Yersinia enterocolitica (YE) O9 infections was reported from a military base in northern Norway. Concurrently, an increase in YE infections in civilians was observed in the Norwegian Surveillance System for Communicable Diseases. We investigated to ascertain the extent of the outbreak and identify the source in order to implement control measures. A case was defined as a person with laboratory-confirmed YE O9 infection with the outbreak multilocus variable-number tandem repeat analysis (MLVA)-profile (5-6-9-8-9-9). We conducted a case–control study in the military setting and calculated odds ratios (OR) using logistic regression. Traceback investigations were conducted to identify common suppliers and products in commercial kitchens frequented by cases. By 28 May, we identified 133 cases, of which 117 were linked to four military bases and 16 were civilians from geographically dispersed counties. Among foods consumed by cases, multivariable analysis pointed to mixed salad as a potential source of illness (OR 10.26; 95% confidence interval (CI): 0.85–123.57). The four military bases and cafeterias visited by 14/16 civilian cases received iceberg lettuce or radicchio rosso from the same supplier. Secondary transmission cannot be eliminated as a source of infection in the military camps. The most likely source of the outbreak was salad mix containing imported radicchio rosso, due to its long shelf life. This outbreak is a reminder that fresh produce should not be discounted as a vehicle in prolonged outbreaks and that improvements are still required in the production and processing of fresh salad products.
Remaining Questions Concerning Wearable Devices—Reply
Authors: Motohiko Miyachi, Haruka Murakami
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Blocking Complement-Mediated Hemolysis of PNH Erythrocytes by RNA Aptamers to C8 and C9.
Authors: Jun-ichi Nishimura, Shahid Nimjee, Haixiang Jiang, Tatsuya Kawaguchi, Hideki Nakakuma, Mitsuhiro Omine, Michael M. Frank, Russell E. Ware, Bruce A. Sullenger
Journal: Blood (2004)
The genome sequence of allopolyploid Brassica juncea and analysis of differential homoeolog gene expression influencing selection
Authors: Jinghua Yang, Dongyuan Liu, Xiaowu Wang, Changmian Ji, Feng Cheng, Baoning Liu, Zhongyuan Hu, Sheng Chen, Deepak Pental, Youhui Ju, Pu Yao, Xuming Li, Kun Xie, Jianhui Zhang, Jianlin Wang, Fan Liu, Weiwei Ma, Jannat Shopan, Hongkun Zheng, Sally A Mackenzie, Mingfang Zhang
Journal: Nature Genetics (2016)

Abstract The Brassica genus encompasses three diploid and three allopolyploid genomes, but a clear understanding of the evolution of agriculturally important traits via polyploidy is lacking. We assembled an allopolyploid Brassica juncea genome by shotgun and single-molecule reads integrated to genomic and genetic maps. We discovered that the A subgenomes of B. juncea and Brassica napus each had independent origins. Results suggested that A subgenomes of B. juncea were of monophyletic origin and evolved into vegetable-use and oil-use subvarieties. Homoeolog expression dominance occurs between subgenomes of allopolyploid B . juncea , in which differentially expressed genes display more selection potential than neutral genes. Homoeolog expression dominance in B . juncea has facilitated selection of glucosinolate and lipid metabolism genes in subvarieties used as vegetables and for oil production. These homoeolog expression dominance relationships among Brassicaceae genomes have contributed to selection response, predicting the directional effects of selection in a polyploid crop genome.
Deferasirox (Exjade®, ICL670) Treatment of Inadequately Chelated β-Thalassemia Patients from the Middle East: The ESCALATOR Trial.
Authors: Ali Taher, Amal El-Beshlawy, Abdullah Al Jefri, Mohsen El Alfy, Kusai Al Zir, Shahina Daar, Ghazi Al-Damanhouri, Dietrich Hadler, Ulrike Krahn
Journal: Blood (2005)
Evaluation of a Risk-Based Algorithm for the Utilization of Plerixafor As Primary Mobilization of CD34+ Cells in Autologous Hematopoietic Cell Transplant Candidates,
Authors: Jamie Shapiro, Janelle Perkins, Ryan Bookout, Rebecca Tombleson, Ernesto Ayala, William E. Janssen, Claudio Anasetti, Hugo F. Fernandez
Journal: Blood (2011)
Influence of surgical interventions on survival in patients with stage IIIb non-small cell lung cancer (NSCLC): The Fox Chase Cancer Center (FCCC) experience.
Authors: W. J. Scott, C. Aggarwal, A. Lebenthal, B. Egleston, H. Borghaei, R. Mehra, N. Somaiah, A. Turaka, G. R. Simon
Journal: Journal of Clinical Oncology (2010)

7067 Background: NSCLC patients (Pts) with T4 and/or N3 disease are categorized as stage IIIB NSCLC. Chemoradiation (CRT) is the standard of care for pts with dry (without malignant pleural effusion) stage IIIB NSCLC. Published results of Intergroup trial, INT 0139, suggests that lobectomy improves survival over CRT in stage IIIA disease. We evaluated the role of surgery in patients with dry stage IIIB to discern whether surgery would have a similar impact in technically resectable cases. Methods: Outcomes of NSCLC pts with dry IIIB disease, treated at FCCC between 01/2000 and 12/2008, were analyzed. Stage IIIB patients were dichotomized in two cohorts, those who had surgery versus those treated non-surgically. The propensity score method was used to balance the two cohorts for histology, age, sex, and smoking status. Kaplan-Meier estimators were used to compare overall survival (OS) between treatment cohorts. Results: The median age was 62 years (y) for the 194 pts with stage IIIb disease, of whom 51% were male. Most pts were Caucasian (85%) and smokers (87%). Sixty two pts had adenocarcinoma (32%), 68 squamous cell (35%) and 64 (33%) had NSCLC not otherwise specified. S was performed in 58 pts (29 lobectomies, 11 pneumonectomies and 18 other procedures) (30%) and 136 (70%) underwent CRT alone. After propensity score based weighting, there were no significant differences in patient characteristics, between the two cohorts. S was significantly superior to CRT (median OS 25 months (mos) vs. 16 mos, p=0.009). One, two and five y OS were 70%, 52% and 40% and 64%, 31% and 13% in the S group and CRT group, respectively. Progression-free survival and OS by T and N descriptors will be presented at the meeting. Conclusions: After propensity based weighting, OS of dry stage IIIB pts treated surgically was superior to pts treated with CRT. A fresh look at the role of surgery in select patients with dry stage IIIB disease may be warranted. No significant financial relationships to disclose.
Adverse Outcomes of Underuse of β-Blockers in Elderly Patients-Reply
Authors: Stephen B. Soumerai
Journal: JAMA (1997)

In Reply.  —Dr Gambassi and colleagues and Dr Holt suggest that the nondihydropyridine calcium channel blockers (eg, verapamil and diltiazem) may be safer or more effective than dihydropyridine calcium channel blockers. However, our study was designed to measure outcomes of β-blocker underuse, not to assess the comparative efficacy of calcium channel blockers. A comparative study would require a different sample (not only patients eligible for β-blockers). Instead, we studied the effects of the substitution of any calcium channel blocker for a trial of β-blockers in patients eligible for β-blockers, a practice at odds with national evidence-based guidelines.1  Gambassi et al also question whether 2 effective drug classes, aspirin and lipid-lowering agents, might be correlated with β-blocker use. Because aspirin is an over-thecounter drug, administrative claims databases do not contain reliable data on its use in community settings. However, a previous report from the United Kingdom indicates much greater use of aspirin
RP6530, a Dual PI3Kδ/γ Inhibitor, Attenutates AKT Phosphorylation and Induces Apoptosis In Primary Cutaneous T Cell Lymphoma (CTCL) Cells
Authors: Julia Lewis, Michael Girardi, Swaroop Vakkalanka, Srikant Viswanadha, Francesco Bertoni
Journal: Blood (2013)
Effect of the American Society of Clinical Oncology’s Conflict of Interest Policy on Information Overload
Authors: Aaron Boothby, Ruibin Wang, Jeremy Cetnar, Vinay Prasad
Journal: JAMA Oncology (2016)

This study of American Society of Clinical Oncology (ASCO) 2014-15 meeting videos characterizes the word count of financial conflict of interest disclosures appearing in slide presentations in response to a policy requiring the disclosure.
A phase I study of bevacizumab in combination with sunitinib, sorafenib, and erlotinib plus cetuximab, and trastuzumab plus lapatinib.
Authors: G. S. Falchook, J. J. Wheler, A. Naing, D. S. Hong, S. L. Moulder, S. A. Piha-Paul, C. S. Ng, E. Jackson, R. Kurzrock
Journal: Journal of Clinical Oncology (2010)

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