tbuckley/cabot-search huggingface dataset:
The Carcinostatic Effect of Extracts Prepared from Cow Ovaries2
Authors: T. R. Tosteson, S. A. Ferguson, E. Davidson, R. J. Rutman
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article The Carcinostatic Effect of Extracts Prepared from Cow Ovaries Get access T. R. Tosteson, T. R. Tosteson Search for other works by this author on: Oxford Academic PubMed Google Scholar S. A. Ferguson, S. A. Ferguson Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Davidson, E. Davidson Search for other works by this author on: Oxford Academic PubMed Google Scholar R. J. Rutman R. J. Rutman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 6, June 1958, Pages 1011–1022, https://doi.org/10.1093/jnci/20.6.1011 Published: 01 June 1958 Article history Received: 28 August 1957 Published: 01 June 1958
Abstract PR03: Combinatorial blockade of PD-1, CTLA-4, and LAG-3 pathways inhibits murine ovarian tumor growth.
Authors: Ruea-Yea Huang, AJ McGray, Kunle Odunsi
Journal: Clinical Cancer Research (2016)

Abstract We have previously shown that tumor-associated or infiltrating T cells (TALs or TILs) often co-express immune inhibitory receptors lymphocyte activation gene-3 (LAG-3) and programmed cell death 1 (PD-1) in human and murine ovarian tumor microenvironment (TME). Dual antibody blockade or genetic knockout of LAG3 and PD1 significantly enhanced T effector function and delayed ovarian tumor growth. The relative contribution of other immune inhibitory receptors to immune suppression in the ovarian TME, and whether they co-regulate each other are currently unknown. To address this, we analyzed the expression of multiple immune checkpoint proteins and their cognate ligands in ovarian tumor-bearing wild-type (WT), LAG3KO and PD1KO mice. We found that PD-1, cytotoxic T lymphocyte antigen 4 (CTLA-4), LAG-3, T-cell immunoglobulin domain and mucin domain 3 (TIM-3) and CD160 were elevated in TILs from the WT mice. Interestingly, compared with TILs of WT mice, the levels of LAG-3, TIM-3, and CTLA-4 were further significantly elevated in TILs from the tumor-bearing PD1KO mice; while the levels of PD-1, CTLA-4, and CD160 were further increased in the tumor-bearing LAG3KO mice. These results suggest that PD-1 and LAG-3 regulate the expression of multiple inhibitory receptors in the ovarian TME. Furthermore, combinatorial blockade with anti-LAG3 and anti-CTLA4 antibodies in the tumor-bearing PD1KO mice resulted in 30% tumor-rejection as compared to 10% by anti-CTLA4 alone or only delayed tumor growth by anti-LAG3. These data provide a strong basis for rational clinical testing of combinatorial blockade of the PD-1, LAG-3 and CTLA-4 immune inhibitory pathways for ovarian cancer immunotherapy. This abstract is also presented as Poster A51. Citation Format: Ruea-Yea Huang, AJ McGray, Kunle Odunsi. Combinatorial blockade of PD-1, CTLA-4, and LAG-3 pathways inhibits murine ovarian tumor growth. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr PR03.
Abstract IA23: Targeting nuclear noncoding RNAs
Authors: David Corey
Journal: Cancer Research (2016)

Abstract RNA interference (RNAi) is well known as a mechanism for controlling mammalian mRNA translation in the cytoplasm, but what would be the consequences if it also functioned in cell nuclei? Although RNAi has also been found in nuclei of plants, yeast, and other organisms, there has been relatively little progress towards understanding the potential involvement of mammalian RNAi factors in nuclear processes including transcription and splicing. When RNAi factors bind small RNAs, they form ribonucleoprotein complexes that can be selective for target sequences within different classes of nuclear RNA substrates. The versatility of nuclear RNAi may supply a previously underappreciated layer of regulation to transcription, splicing, and other nuclear processes. This talk focuses on recent work targeting noncoding RNA at the frataxin and C9orf72 loci as examples for how nuclear RNAi can be used to control gene expression. Citation Format: David Corey. Targeting nuclear noncoding RNAs. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr IA23.
Dengue virus infection in travellers returning from Benin to France, July – August, 2010
Authors: M L Moi, M Ujiie, T Takasaki, I Kurane
Journal: Eurosurveillance (2010)

Preview this article: Dengue virus infection in travellers returning from Benin to France, July – August, 2010, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/39/art19674-en-1.gif
Abstract P2-13-08: Breast lipofilling: A systematic review of current practice and oncological safety
Authors: U Wazir, A Kasem, H Headon, K Mokbel
Journal: Cancer Research (2016)

Abstract Background: Lipofilling is a reconstructive and aesthetic technique that has recently grown in popularity and is increasingly being used in breast surgery. Concerns had been raised regarding its safety when used for remodelling and reconstruction of the breast. Methods: We reviewed the current literature by systematically searching PubMed and Google Scholar databases regarding the current evidence regarding the oncological safety of the procedure in patients seeking aesthetic breast enhancement and in patients requiring oncoplastic reconstruction. Results: Among the 864 patients included in the currently available studies on breast cancer patients who underwent lipofilling, only 14 (1.6%) recurrences were identified. However, evidence has emerged suggestive that the use of lipofilling in the background of ductal carcinoma in situ (DCIS) may be associated with an increased risk of neoplasia. Conclusions: Over the subsequent two decades, little evidence has been found to support these early theoretical concerns, and growing numbers of proponents of the procedure are confident in its safety. Further study is required to better delineate the effect of lipofilling on DCIS. Citation Format: Wazir U, Kasem A, Headon H, Mokbel K. Breast lipofilling: A systematic review of current practice and oncological safety. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-13-08.
Nighttime and daytime efficacy of flurazepam and oxazepam in chronic insomnia
Authors: D Bliwise, W Seidel, D J Greenblatt, W Dement
Journal: American Journal of Psychiatry (1984)

Trials of hypnotic medications typically determine efficacy by examining changes in polysomnographically recorded sleep and in daytime performance. The authors employed daytime sleepiness as a new, potentially crucial criterion in such trials. Oxazepam and flurazepam were effective in improving some polysomnographically defined measures of nocturnal sleep in 14 patients with chronic insomnia; flurazepam produced substantial daytime sleepiness and oxazepam did not. Oxazepam produced some rebound insomnia, consisting of about an hour's reduction of polysomnographically defined sleep, but without gross mood disturbance or the patients' awareness of sleep loss.
Docetaxel + Trastuzumab +/- Non-Pegylated Liposomal Doxorubicin +/- Bevacizumab in the Neoadjuvant Treatment of Early, Her2-Positive Breast Cancer: First Results of Abcsg-32
Authors: G.G. Steger, R. Greil, M. Hubalek, M.A. Fridrik, C. Singer, R. Bartsch, M. Balic, P. Dubsky, D. Egle, S.P. Gampenrieder, G. Pfeiler, D. Mayr, T. Czech, G. Rinnerthaler, A.L. Petzer, P. Sevelda, A. Lang, S. Frantal, M. Rudas, M. Gnant
Journal: Annals of Oncology (2014)
99mTc-hexamethylpropyleneamine oxime single photon emission CT in poststroke depression
Authors: J A Schwartz, N M Speed, J M Mountz, M D Gross, J G Modell, D E Kuhl
Journal: American Journal of Psychiatry (1990)

In this pilot study of poststroke depression, the authors evaluated regional cerebral blood flow and depression in 14 stroke patients. Volume of ischemia was measured by two methods, which were highly correlated. Depression scores correlated with lesion volume as measured by single photon emission CT.
Unification Church ("Moonie") dropouts: psychological readjustment after leaving a charismatic religious group
Authors: M Galanter
Journal: American Journal of Psychiatry (1983)

Of 66 persons who left the Unification Church (the "Moonies"), twenty-three (36%) reported that they had had serious emotional problems after leaving. After an average of 3.8 years, however, the former members studied here had apparently achieved a stable adjustment. Most of them retained a notable fidelity toward the sect and its beliefs, but those who had been "deprogrammed" had more negative views and themselves had coerced other members to leave. The author examines the impact of group membership on individual development and looks at departure in relation to the psychopathology, such as depression and paranoid ideation, that may emerge.
Azacitidine In The Treatment Of Ph- Myeloproliferative Neoplasms In Blastic Phase: The Experience Of Gruppo Laziale For The Study Of Ph- SMPC
Authors: Roberto Latagliata, Maria Teresa Voso, Nicoletta Villivà, Fabrizio Ciccone, Cristina Andrizzi, Cinzia De Gregoris, Francesco Buccisano, Angelo De Blasio, Barbara Anaclerico, Giuseppe Avvisati, Antonino Bagnato, Michele Cedrone, Giuseppe Cimino, Ignazio Majolino, Enrico Montefusco, Antonio Spadea, Giuliana Alimena, Marco Montanaro
Journal: Blood (2013)
Abstract IA11: Differential networks and drug networks: A computational approach to drug discovery
Authors: Diego di Bernardo
Journal: Cancer Research (2015)

Abstract Genome scale expression profiles (GEPs) of tumor samples versus non-tumor sampls can be analysed via innovative computational approaches to identify altered pathways and driver genes. These results can then be used to make identify appropriate small molecule therapies. We developed and validated computational strategy, called Differential Co-expression Analysis (DiCA), to infer metabolic, signaling and regulatory pathways which are altered across two conditions (i.e. tumor vs non-tumor). DiCA is built on the hypothesis that genes in an active pathway are more likely to be regulated and hence co-expressed. On the contrary, inactive pathways will results in uncoordinated gene expression. DiCA measures how much a set of genes is co-expressed using a multidimensional information metrics. We apply DiCA to 100 Human HepatoCarcinoma samples collected within the MODHEP European Project. We demonstrate how DMI is able to correctly identify altered pathways known to be affected by HCC and to propose new hypothesis on HCC pathogenesis, which would be missed by conventional Differential Expression. We then show how GEPs from cancer samples can be used also to query a “drug network” by comparing them to transcriptional responses induced by drug treatment. The end result is a list of drugs which induce a transcriptional response similar to that of cancer samples thus hinting at which pathways are perturbed. Analogously, drugs inducing an “anti-similar” response, i.e. up regulating genes down regulated in cancer and vice-versa, could be investigated as potentially therapeutic. We tested these hypotheses on HCC samples demonstrating their potential usefulness. Citation Format: Diego di Bernardo. Differential networks and drug networks: A computational approach to drug discovery. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr IA11.
New potential diagnostic biomarkers for pulmonary hypertension
Authors: Svenja L. Tiede, Henning Gall, Oliver Dörr, Marina dos Santos Guilherme, Christian Troidl, Christoph Liebetrau, Sandra Voss, Robert Voswinckel, Ralph T. Schermuly, Werner Seeger, Friedrich Grimminger, Andreas M. Zeiher, Stefanie Dimmeler, Helge Möllmann, Christian W. Hamm, Hossein Ardeschir Ghofrani, Holger M. Nef
Journal: European Respiratory Journal (2015)

This study aimed to determine whether the vascular endothelial growth factor (VEGF) family members soluble VEGF receptor 1 (also called soluble fms-like tyrosine kinase 1 (sFlt-1)) and placental growth factor (PlGF) could be used as biomarkers for pulmonary hypertension (PH). Consecutive patients undergoing right heart catheterisation were enrolled (those with mean pulmonary arterial pressure ≥25 mmHg were classed as having PH; those with mean pulmonary arterial pressure <25 mmHg acted as non-PH controls). Plasma from the time of PH diagnosis was analysed for PlGF and sFlt-1 using enzyme immunoassays. In total, 247 patients with PH were enrolled: 62 with idiopathic pulmonary arterial hypertension (IPAH), 14 with associated pulmonary arterial hypertension (APAH), 21 with collagen vascular disease (CVD), 26 with pulmonary venous hypertension, 67 with lung disease-associated PH and 57 with chronic thromboembolic PH. The non-PH control group consisted of 40 patients. sFlt-1 plasma levels were significantly higher in patients with IPAH, APAH, CVD and lung disease-associated PH versus controls; PlGF levels were significantly higher in all PH groups versus controls. The combination of sFlt-1 and PlGF resulted in a sensitivity of 83.7% with specificity of 100% for pulmonary arterial hypertension. There was no association between sFlt-1 or PlGF and haemodynamic parameters, 6-min walking distance or survival. In summary, PlGF and sFlt-1 are promising diagnostic biomarkers for PH.
Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions
Authors: Bei Gao, Xiaoming Bian, Ridwan Mahbub, Kun Lu
Journal: Environmental Health Perspectives (2016)

There is growing recognition of the significance of the gut microbiome to human health, and the association between a perturbed gut microbiome with human diseases has been established. Previous studies also show the role of environmental toxicants in perturbing the gut microbiome and its metabolic functions. The wide agricultural use of diazinon, an organophosphate insecticide, has raised serious environmental health concerns since it is a potent neurotoxicant. With studies demonstrating the presence of a microbiome-gut-brain axis, it is possible that gut microbiome perturbation may also contribute to diazinon toxicity.We investigated the impact of diazinon exposure on the gut microbiome composition and its metabolic functions in C57BL/6 mice.We used a combination of 16S rRNA gene sequencing, metagenomics sequencing, and mass spectrometry-based metabolomics profiling in a mouse model to examine the functional impact of diazinon on the gut microbiome.16S rRNA gene sequencing revealed that diazinon exposure significantly perturbed the gut microbiome, and metagenomic sequencing found that diazinon exposure altered the functional metagenome. Moreover, metabolomics profiling revealed an altered metabolic profile arising from exposure. Of particular significance, these changes were more pronounced for male mice than for female mice.Diazinon exposure perturbed the gut microbiome community structure, functional metagenome, and associated metabolic profiles in a sex-specific manner. These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism contributing to diazinon neurotoxicity and, in particular, its sex-selective effects. Citation: Gao B, Bian X, Mahbub R, Lu K. 2017. Sex-specific effects of organophosphate diazinon on the gut microbiome and its metabolic functions. Environ Health Perspect 125:198-206; http://dx.doi.org/10.1289/EHP202.
Abstract B24: Identification of immunosuppressive networks in colon cancer
Authors: Anne E. Sarver, Aaron L. Sarver, Subbaya Subramanian
Journal: Cancer Research (2016)

Abstract Despite important improvements over the past two decades in preventive screening and targeted therapies, colorectal cancer remains the third major cause of cancer-related deaths in the U.S. The majority (~85%) of colon cancer tumors are non-immunogenic, i.e. they lack a significant number of infiltrating cytotoxic T cells, and are typically unresponsive to the new immune-checkpoint inhibitor based therapies that have dramatically changed the way we treat many cancer patients. These non-immunogenic colon cancer tumors are also characterized by chromosome instability and are microsatellite stable (MSS). Microsatellite instable (MSI) tumors present a greater variety of antigens and are significantly more immunogenic. We analyzed the paired mRNA and microRNA RNA-Seq expression profiles contained in The Cancer Genome Atlas (TCGA), representing MSS colon cancer, MSI colon cancer, and normal colon tissues. These expression profiles reflect the heterogeneity of the tumor samples, with MSI samples showing distinct immune cell signatures. Integrative analysis of mRNA and microRNA expression patterns revealed signaling networks that may represent, in part, the molecular mechanisms by which cancer cells modulate the host response to create an immune privileged microenvironment. These findings could result in a novel therapeutic avenue, targeting a tumor's ability to suppress the immune response, addressing a critical barrier to treatment for non-immunogenic tumors. Citation Format: Anne E. Sarver, Aaron L. Sarver, Subbaya Subramanian. Identification of immunosuppressive networks in colon cancer. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr B24.
Abstract P6-17-06: Relevance of the hyaluronidase-1 (HYAL1) in brain metastasis formation of breast cancer patients
Authors: L Oliveira-Ferrer, M Anna, H Wickman, J Matschke, U Schumacher, K Milde-Langosch, V Müller, I Witzel
Journal: Cancer Research (2016)

Abstract The incidence of brain metastases in breast cancer (BMBC) patients has increased in the last years and represents the major life-limiting problem for metastatic breast cancer (BC) patients. However, the knowledge about tumor cell invasion in the brain is still very limited and new markers for brain metastasis incidence are urgently needed in order to early detect high risk patients. In a recent study based on cDNA microarray data of primary breast tumors, we could show that mRNA expression of certain glycosylation enzymes significantly correlates with an organ-specific metastatic spread. Interestingly, hyaluronan synthase 2 (HAS2) and hyaluronidase-1 (HYAL1), both genes involved in hyaluronan (HA) metabolism, showed an independent prognostic value and a significant correlation with brain metastasis formation. In order to corroborate the role of these enzymes at protein level, we examined the expression of HYAL1 and HAS2 on a tissue microarray including 200 primary BC samples. Here, the prognostic impact of HAS2 could not be validated, whereas for HYAL1 shorter disease free survival (DFS) was observed for patients with high HYAL1-expression levels. This trend could be additionally verified in a second cohort of 107 BC samples, using western blot analysis. Moreover, significantly higher HYAL1 expression was detected among primary tumors with subsequent brain metastases compared with those without brain metastases using immunohistochemistry (IHC). No impact of HYAL1 expression on disease progression of BCBM patients could be observed after analysis of 87 brain metastasis samples. Here, quantification of tumor-associated HA revealed a significant positive correlation with triple negative tumors and a trend towards shorter progression-free survival. Taken together, our data suggest a role of the enzyme HYAL1 for progression and especially for the development of brain metastases in breast cancer patients. Citation Format: Oliveira-Ferrer L, Anna M, Wickman H, Matschke J, Schumacher U, Milde-Langosch K, Müller V, Witzel I. Relevance of the hyaluronidase-1 (HYAL1) in brain metastasis formation of breast cancer patients. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-17-06.
Cancer Mortality Among Alaskan Natives, 1960–69
Authors: William J. Blot, Anne Lanier, Joseph F. Fraumeni, Thomas R. Bender
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Cancer Mortality Among Alaskan Natives, 1960–69 Get access William J. Blot, Ph.D., William J. Blot, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Anne Lanier, M.D., Anne Lanier, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph F. Fraumeni, Jr., M.D., Joseph F. Fraumeni, Jr., M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas R. Bender, M.D. Thomas R. Bender, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 3, September 1975, Pages 547–554, https://doi.org/10.1093/jnci/55.3.547 Published: 01 September 1975 Article history Received: 29 January 1975 Accepted: 21 May 1975 Published: 01 September 1975
Health Literacy
Authors: Janet M. Torpy, Alison E. Burke, Robert M. Golub
Journal: JAMA (2011)

Health LiteracyH ealth literacy is the ability to understand your health, medical care, and overall wellness.However, research shows that many adults find health information hard to understand.This includes what doctors, nurses, pharmacists, and other health care professionals say, written medical instructions, and health insurance forms.Even when people have good access to health services, lack of information can make it difficult for patients and families to properly manage their health.The September 14, 2011, issue of JAMA includes an article about health literacy in patients.Most people may find health care terms and instructions challenging to understand.However, low health literacy is particularly common among elderly persons, individuals with a chronic illness or disability, persons who live in poverty, individuals who do not speak English, and persons with a mental illness.Research studies are looking at ways to provide easy-to-understand health information to help people with low health literacy make good decisions.In the meantime, here are some ways you can get the most out of a visit to your doctor.