tbuckley/cabot-search huggingface dataset:
Dietary Fat Intake and the Risk of Coronary Heart Disease in Women
Authors: Frank B. Hu, Meir J. Stampfer, JoAnn E. Manson, Eric Rimm, Graham A. Colditz, Bernard A. Rosner, Charles H. Hennekens, Walter C. Willett
Journal: New England Journal of Medicine (1997)

The relation between dietary intake of specific types of fat, particularly trans unsaturated fat, and the risk of coronary disease remains unclear. We therefore studied this relation in women enrolled in the Nurses' Health Study.
GW25-e5212 Lipoxin A4 inhibits lipid uptake and oxLDL-induced apoptosis in macrophages with suppressed biosynthesis in atherosclerotic arteries
Authors: Mai Jingting, Yangxin Chen, Qiong Qiu, Woliang Yuan, Jingfeng Wang, Jingfeng Wang
Journal: Journal of the American College of Cardiology (2014)
Safeguards in Gastric Resection for Duodenal Ulcer
Authors: Frederick P. Ross, Richard Warren
Journal: New England Journal of Medicine (1951)

IT IS the purpose of this communication to present a program of management of the technical aspects of extensive partial gastrectomy for complicated duodenal ulcer that has gradually evolved in this clinic in the four-and-one-half-year period ending January, 1951. As in any teaching surgical service, the training of young surgeons is second in importance only to providing the best possible care for the patient seeking aid in the hospital. Of 200 consecutive resections for duodenal ulcer (including 9 cases of marginal ulcer, which is the same disease but slightly disguised by the altered anatomy resulting from previous inadequate surgery), 104, . . .
THU0206 Population-based epidemiology and description of behcet’s disease in the african descent population of martinique, french west indies
Authors: C. Deligny, L. Antonio, H. Merle, P. Numéric, A. Signate, V. Dehlinger, G. Jean Baptiste, S. Arfi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> No study describes the frequency of Behcet’s disease (BD) in the populations of African origin and its characteristics. <h3>Objectives</h3> To retrospectively assess by retrieval of multiple sources, the epidemiology and characteristics of BD in the mainly African descent population of Martinique, a French Island in the Caribbean. <h3>Methods</h3> In 2011 we consulted 5 different sources. Patients were included if they lived in Martinique, were classified as certain if they fulfilled the international criteria for BD. The diagnosis was considered only as probable if they had recurrent oral ulcers with at least one other international criteria but no other possible diagnosis. The incidence during the 1997-2011 interval and prevalence at December 31, 2010 were calculated. Basic and BD-related characteristics were recorded. <h3>Results</h3> 48 patients were indicated as BD. Only 36 (female, n=22; male, n=14) fulfilled the criteria. Mean age at diagnosis was 38.5 years old (range: 8-64), 36.6 for women and 41.6 for men. Disease onset was over 50 years old for 7 patients. Mean time between first signs and diagnosis was 4.2 years (range: 0-22). Twenty eight began their disease between 1997 and 2011 allowing a total crude mean annual incidence estimation of 0.72 new cases/10<sup>5</sup> inhabitants (0.79/10<sup>5</sup> for female and 0.59/10<sup>5</sup> for males, 0.37/10<sup>5</sup> for certain cases and 0.35/10<sup>5</sup> for probable). In December 2010, 28 patients were alive, 5 lost to follow up and 3 deceased: the crude prevalence was estimated as 7.04/10<sup>5</sup> inhabitants (Female: 7.49; male: 6.51). Genital ulcers were found in 75.6%. Dermatological manifestations were: pseudofolliculitis (52%), erythema nodosum (13.5%). Pathergy test was done for 6 patients and positive for 4. Nine patients had ophthalmologic involvement: anterior uveitis (55.5%, n=5), panuveitis and posterior uveitis (11.1%, n=1 each), conjunctival ulceration (22.2%, n=2). Parenchymal brain involvement was more frequent than non-parenchymal (7 versus 3 patients) without any cerebral venous thrombosis. Rheumatic manifestations were occurred in 20 patients (55.6%) mainly females (60%): polyarthritis (38.9%), monoarthritis and spondylarthropathy (11.1% each). Deep vein thromboses were seen in 2 cases and superficial in 1, central retinal artery occlusion in 1 patient. The colon was involved in 6 cases and the ileo-cecal region in one. <h3>Conclusions</h3> In Martinique, BD seems to be a rare disease compared to Mediterranean and most Asian countries. The incidence is comparable to Spain and Switzerland. The prevalence is higher than in most European countries and USA. Black population seems to have particular manifestations of BD: older age at onset and rare uveitis. <h3>Disclosure of Interest</h3> None Declared
Post-mortem findings in a patient with avian influenza A (H5N6) virus infection
Authors: R. Gao, M. Pan, X. Li, X. Zou, X. Zhao, T. Li, H. Yang, S. Zou, H. Bo, J. Xu, S. Li, M. Zhang, Z. Li, D. Wang, S.R. Zaki, Y. Shu
Journal: Clinical Microbiology and Infection (2016)
Abstract 4027: Pathway analysis of chemoresistance in ovarian cancer cell lines.
Authors: William P. Jackson, Ashwini A. Katre, Zachary A. Dobbin, Adam D. Steg, Charles N. Landen
Journal: Cancer Research (2013)

Abstract Introduction: Ovarian Cancer is the most deadly female reproductive cancer and fifth most common cause of death from cancer among women. Limited characterization of the chemoresistant population demonstrates the need for improved therapy for ovarian cancer. Pathway analysis of microarray data of paired chemosensitive and chemoresistant ovarian cancer cell lines may help to elucidate important contributors to chemoresistance, and paired analyses can eliminate the significant heterogeneity among patient samples. Significant genes may serve as potential targets for novel drug therapies. Some genes likely contribute to resistance of multiple chemotherapies and represent common pathways of resistance. Methods: Microarray data of three pairs of chemosensitive and chemoresistant ovarian cancer cell lines were analyzed using GeneSpring Single Experiment Analysis of 517 pathways. These pairs include SKOV3ip1 and SKOV3TRip2 (taxane-resistant), HeyA8 and HeyA8MDR (multi-drug resistant), and A2780cp20 and A780cp55 (increasing cisplatin resistance). Significant genes within significant pathways were compared between types of drug resistance. Results: Between SKOV3ip1 and SKOV3TRip2, 8 pathways were significantly (p&amp;lt;0.001) modulated, dominated by the selenium pathway and folate/B12 metabolism. Between HeyA8 and HeyA8MDR, 9 pathways were significantly modified, led by DNA regulation and cell cycle progression. These differences between the SKOV3 model were interesting, given that both chemoresistant lines were developed in the same way. In A2780cp20 and A2780cp55, 7 pathways were significantly affected, highlighted by members of the Electron Transport Chain and controls on oxidative phosphorylation and autophagy. Validation of individual genes as important to chemoresistance will follow from this analysis. Conclusions: Multiple pathways are implicated in chemoresistance, even when selected by the same chemotherapeutic agent. Pathways contributing to metabolism, DNA repair, cell cycle control, and stress responses dominated. The high variability in pathway overexpression highlights the importance of patient-specific approaches to overcoming chemoresistance in ovarian cancer. Citation Format: William P. Jackson, Ashwini A. Katre, Zachary A. Dobbin, Adam D. Steg, Charles N. Landen. Pathway analysis of chemoresistance in ovarian cancer cell lines. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4027. doi:10.1158/1538-7445.AM2013-4027
Abstract 3452: Role of P-glycoprotein in carcinogenesis
Authors: Lihua Wang, Weiwu Jiang, Bhagavatula Moorthy, Sudha Rani Kondraganti
Journal: Cancer Research (2010)

Abstract Cancer accounts for nearly one-quarter of deaths in the United States, exceeded only by heart diseases. Polycyclic aromatic hydrocarbons (PAHs) are commonly found in our environment and appear to be carcinogenic by genotoxic mechanisms. Several studies show that over-expression of P-glycoprotein (Pg-p, coded by mdr1) is associated with the development of various cancers. High expression of the mdr1 gene has been reported in many human cancers such as in breast, liver, colon, kidney and brain. Many molecular and cellular studies have revealed the ability of dietary phytochemicals in vegetables and fruits to reduce the risk of cancer. The abundant and inexpensive dietary phytochemicals are being explored as Pg-p modulators in cancer chemoprevention and chemotherapy. In the present study, we investigated the role of P-gp in cancer development. We also studied whether the inhibition of P-gp function could reduce the development of cancer. The wild type (C57BL/6J) mice were exposed to the environmental PAH, 7, 12-dimethylbenz(a)anthracene (DMBA) and dietary phytochemicals, alone and in combination. The hepatic and mammary gene expressions of P-gp, Pregnane X receptor (PXR), and CYP3A11 were analyzed. The environmental PAHs induced hepatic and mammary expressions of P-gp and associated genes in mice, compared to controls. Administration of dietary phytochemicals inhibited the P-gp expression significantly. Induction of specific DNA adducts were also observed in hepatic and mammary tissues of mice treated with PAHs and phytochemicals. These studies show a potential for development of dietary phytochemicals as Pg-p modulators in chemoprevention and chemotherapy of human cancers. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3452.
New Technologies Proving Useful For Breast Cancer Diagnosis
Authors: Cheri Vogi
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article New Technologies Proving Useful For Breast Cancer Diagnosis Get access Cheri Vogi Cheri Vogi Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 2, 20 January 1993, Pages 88–90, https://doi.org/10.1093/jnci/85.2.88 Published: 20 January 1993
A Pleomorphic Carcinoma of the Lung with Small Intestinal Metastasis Producing Multiple Cytokines
Authors: S. Hara, K. Hosoi, Y. Suga, T. Takata, H. Degami, Y. Kinoshita, K. Min, S. Katsuyama, O. Takayama, M. Murata
Journal: Annals of Oncology (2013)
Transient lodine Organification Defect in Infants With Ectopic Thyroid Glands
Authors: NASIR A.M. AL-JURAYYAN, MAHMOUD I. EL-DESOUKI
Journal: Clinical Nuclear Medicine (1997)

Thyroid gland ectopy is the most common cause in infants with congenital hypothyroidism (CH). Its association with iodine organification defect, as suggested by positive perchlorate discharge test (PDT) has been reported. However, whether such an association represents a true or transient defect has not yet been determined. This finding has an important clinical, epidemiological, and genetic implications.To determine the natural history of iodine organification defect in patients with CH caused by thyroid ectopy detected by neonatal screening.Prospective longitudinal study.King Khalid University Hospital, Riyadh, Saudi Arabia.PDT was performed, at the time of diagnosis and follow-up, in infants who showed an enlarged ectopic thyroid gland with a Tc-99m pertechnetate uptake of 2% or more.Of 115 neonates with ectopic thyroid glands, 19 showed an enlarged gland with Tc-99m uptake ranging from 2 to 3.2%. Perchlorate discharge test was performed in 13 of these and was consistent with iodine organification defect in nine. Repeated PDT in seven patients showed normal values.The results of the authors' study indicate the transient nature of the iodine organification defect and suggest that a delay in the developmental of synthetic mechanisms occur in the dysgenetic glands.
P215 The influence of age on management of lung cancer patients in England
Authors: P. Beckett, I. Woolhouse, M. D. Peake, R. Stanley, R. N. Harrison
Journal: Thorax (2010)

Introduction The evidence on which to base treatment decisions in the elderly patient with lung cancer is generally considered to be inadequate, with significant under-representation of older patients in key clinical trials. Although European recommendations have recently been published confirming the benefits of active treatment (EORTC Elderly Task Force), there are no UK guidelines and anecdotal evidence suggests that in the UK elderly patients have much lower rates of active treatment for lung cancer. Methods Using the National Lung Cancer Audit dataset of 27 815 patients first seen in 2008, we have analysed a variety of measures according to patient age at the time of diagnosis. Patients outside the range 38–96 were excluded due to low numbers. Results Comparison with Cancer Research-UK data shows that the elderly are not under-represented in the dataset; neither is there any evidence of under-reporting of key case-mix variables such as PS and Stage. Older patients tend to have lower stage at diagnosis, but this may be due to a reduced intensity of investigations. Not unexpectedly, there is a rapid decline in the proportion with good PS after age 70. Whilst FEV1 (absolute) declines with age, the average FEV1% of predicted remains quite constant at around 70%. There is an increase in recording of co-morbidities from around 5% in young patients to around 20% in the very elderly. There is a clear and dramatic fall in a number of measures of process and treatment such as histological confirmation rate, anti-cancer treatment, and chemotherapy use beginning around the 7th decade of life. The histological confirmation rate falls from 75% at age 65 to 40% at age 85—the corresponding rates for specific anti-cancer therapy are 65% and 25%. More concerning is the finding that these variations persist when corrected for PS and co-morbidities (see [Abstract P215 Figure 1][1]), with treatment rates falling from 50% to 4%. ![Abstract P215 Figure 1][2]</img> Abstract P215 Figure 1 Anti-Cancer treatment in PS 0–2, no co-morbidities Conclusions Age appears to be an important factor in management decisions in English lung cancer practice. The results indicate that further work is warranted to determine how far the results can be explained by patient preference, appropriate physician judgement and physician prejudice. [1]: #F1 [2]: pending:yes
P674Metabolic deregulation in myocardial infarction is mediated by PGC-1 alpha pathway
Authors: MJ Forteza, R Zaragoza, E De Dios, A Hervas, C Bonanad, F Chaustre, G Minana, A Ruiz-Sauri, JR Vina, V Bodi
Journal: Cardiovascular Research (2014)

Purpose: In the context of myocardial infarction (MI) the availability of metabolites is clearly restricted, therefore a fuel metabolic shifts takes place. Previous studies have indicated that peroxisome proliferator activated receptor co-activator alpha (PGC-1α) pathway is a crucial regulator of cardiac metabolism in response to cardiac stress. Here we address the role of PGC-1α in regulating metabolic changes of MI.
TCT-796 Comparison of Three Contemporary Surgical Scores For Predicting All-Cause Mortality Of Patients Undergoing Percutaneous Mitral Valve Repair With The MitraClip System: Insights From The Multicenter GRASP-IT Registry
Authors: Marianna Adamo, Davide Capodanno, Stefano Cannata, Cristina Giannini, Marco Barbanti, Salvatore Curello, Sebastiano Immè, Diego maffeo, Francesco Bedogni, Anna Sonia Petronio, Federica Ettori, Corrado Tamburino
Journal: Journal of the American College of Cardiology (2014)
PMO-159 Ethnic origin and variation in outcome in patients with hepatocellular carcinoma and hepatitis B infection
Authors: J R L Maggs, M A Heneghan, N Heaton, J G O'Grady, K Agarwal, A R Suddle
Journal: Gut (2012)

<h3>Introduction</h3> Hepatocellular carcinoma (HCC) is a major cause cancer-related mortality, world wide. In particular, HCC is associated with chronic hepatitis B infection (CHB) in Africa and South East Asia. Most published data relating to the natural history of CHB and HCC originates from South East Asia; however due to differences in HBV genotype and potential environmental and genetic factors, it is not clear whether this data are applicable to the African population. Therefore, to explore this issue we have compared the characteristics and outcomes of patients with CHB and HCC according to ethnic origin. <h3>Methods</h3> Patients with HCC complicating CHB, managed at King9s College Hospital London, were identified from our clinic databases. Demographic information, laboratory parameters, initial tumour staging and outcome data, including HBe-antigen status, viral load and genotype, were collated where available. Comparison was performed between Black patients and patients of South East Asian origin. <h3>Results</h3> In total, 295 patients with HCC and CHB were identified. Median age at the diagnosis of tumour was 37 years and 85% of patients were male. Ethnicity was classified as Black in 27% of patients and South East Asian in 21% of these patients. Cirrhosis was present in 81% whereas 8% were non-cirrhotic at diagnosis of HCC; data were unavailable in the remaining 11% of patients. 18% were HBe-antigen positive and 7% hepatitis C antibody positive. The distribution of HBV genotypes varied according to ethnic group, with genotypes A and E restricted to Black patients and genotypes B and C to South East Asian patients. On comparing these two groups, there were no differences in gender, the presence of cirrhosis, co-factors for liver disease, laboratory parameters or tumour stage, as assessed by the BCLC staging system. However, Black patients were significantly younger (median age: 44 vs 61 years, p&lt;0.001). Although not significant, there was a trend towards a greater frequency of HBe-antigen positivity in the Black patients. No difference in viral load was observed. There was an increased probability of death within the follow-up period in the Black group (66% vs 39%, p=0.004). Comparison of Kaplan–Meier survival curves for the two groups demonstrated decreased survival following diagnosis of HCC in the Black group (log rank: p=0.31). <h3>Conclusion</h3> In our cohort, we have observed that Black patients present at a younger age and have poorer length of survival in comparison to South East Asian patients. This may represent a more aggressive HCC phenotype that is associated with HBV genotypes A and E although there are potentially multiple confounding factors. Further research is required to determine the cause of this apparent inequality. <h3>Competing interests</h3> None declared.
Abstract 1863: MutL homolog 1 promoter polymorphism in prostate cancer and benign prostatic hyperplasia
Authors: Yuichiro Tanaka, Jan Liu, Mohd S. Zaman, Shahana Majid, Sharanjot Saini, Yi Chen, Kazumori Kawakami, Angela V. Dahiya, Gaurav Khatri, Guoren Deng
Journal: Cancer Research (2010)

Abstract MutL homolog (MLH1) is one of several DNA mismatch repair genes of which defects can result in mutation and genomic instability, and ultimately may lead to cancer. Polymorphisms of MLH1 promoter have been shown to be a risk for several types of cancers and thus, we hypothesize that MLH1 promoter polymorphisms can be a risk factor for prostatic diseases. To test this hypothesis, the genetic distribution of MLH1 polymorphism of the promoter region at nucleotide positions prior to translation start site at −1913 (rs34013758), −593 (rs34566456), −93 (rs1800734) and recently identified −107 (base change C to G) were analyzed in 131 normal healthy subjects, 134 benign prostatic hyperplasia (BPH), and 177 sporadic prostate cancer samples in a Japanese population by sequence-specific PCR and sequencing. These experiments show that the variant G/G genotype at the −93 location is associated with prostate cancer when compared to normal controls. Odds ratio and 95% confidence interval for cancer were 1.93 and 1.01-3.69, respectively, for the variant G/G genotype when compared to wildtype (A/A). Likewise, the variant G allele was associated as a risk for prostate cancer (P=0.063). However, no differences were observed for the promoter −93 polymorphism between BPH and controls as well as between stages or grades of prostate cancer. Interestingly, when analyzing the promoter −93 site with the Ile219Val (A to G) polymorphic site, a significant linkage was observed among controls (D’=1). Haplotype analysis showed bases A-A reflecting the wildtype forms for −93 and Ile219Val sites, respectively, to be significantly reduced in cancer compared to controls (P=0.033). The promoter −107 site was extremely rare with C/G type observed in one cancerous patient whereas rs34013758 and rs34566456 were not observed in this Asian population. This is the first report that demonstrates an association for the MLH1 promoter polymorphism with prostate cancer and these results are important in understanding its role in this disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1863.
PWE-106 Is it necessary for all colorectal cancer patients with liver metastasis to be discussed at a hepatobiliary MDT?
Authors: S Vasudevan, J Wright, M Rees, B Creswell, D Stiff, A Wordley, R Motson
Journal: Gut (2012)

<h3>Introduction</h3> Current guidelines suggest an opinion from a hepatobiliary MDT should be sought for all patients with colorectal cancer liver metastasis. This places a significant burden of work on the hepatobiliary MDT who are often the referral centre for many hospitals (Approximately 20 cases per month at our referral centre). This study was performed to see if our local colorectal MDT was able to make a correct decision regarding referral for consideration of liver resection by comparing its decision with the decision from two hepatobiliary surgeons from our referral network. <h3>Methods</h3> CT scans from 38 patients found to have liver metastasis from colorectal cancer were anonymised and sent to two hepatobiliary surgeons in our cancer network (Pelican Centre, Basingstoke). They classified them into three categories; U—Unresectable, C—Chemo to downstage then consider resection and R—Resectable. The results were then compared with the opinion of our local colorectal MDT made prior to the referral to the hepatobiliary MDT. <h3>Results</h3> The two independent hepatobiliary surgeons agreed with each other on 35/38 (92%) of the CT scans. Our CRC MDT agreed with the hepatobiliary surgeons in 36/38 (95%) of cases. Only 6/29 (21%) patients deemed suitable by review of the CT scan by the hepatobiliary surgeons went on to have a liver resection due to a variety of disease and patient factors. <h3>Conclusion</h3> Our results show that our local colorectal MDT was able to make an accurate assessment of the need for referral for consideration of liver resection in this group of patients. We question the need for all similar cases to be “automatically” discussed with a hepatobiliary MDT such as those patients with wide spread liver disease. It is clear from the fact that only 21% of suitable patients for liver resection went on to have a resection that the colorectal MDT is making complex decisions based on many other patient factors. <h3>Competing interests</h3> None declared.
FEASIBILITY AND EFFECTIVENESS OF A MULTIDISCIPLINARY TEAM APPROACH IN REFRACTORY CARDIOGENIC SHOCK: A PROSPECTIVE PILOT STUDY
Authors: Byung-Soo Ko, Anwar Tandar, Tae Soo Kang, Stephen McKellar, Josef Stehlik, Greg Stoddard, Jack Morshedzadeh, Antigone Koliopoulou, Edward Gilbert, Jose Nativi-Nicolau, Omar Wever-Pinzon, Rashmee Shah, James Fang, Craig Selzman, Frederick Welt, Stavros Drakos
Journal: Journal of the American College of Cardiology (2016)