tbuckley/cabot-search huggingface dataset:
OP17 Clinical effect of albumin dialysis in patients with intractable pruritus correlates closely with changes in autotaxin activity but not bile salt levels
Authors: P Leckie, G Tritto, A E Kremer, R P Mookerjee, N Davies, D Jones, R P J Oude Elferink, R Jalan, U Beuers
Journal: Gut (2010)

Introduction About 5% of patients with severe cholestatic liver disease have intractable pruritus. Albumin dialysis is an effective treatment for these patients but the mechanism through which it reduces the severity of pruritus is not clear. Autotaxin (ATX) is a 125 kD protein which cleaves a choline group of lysophosphatidylcholine (LPC) thereby forming the biological active lysophosphatidic acid (LPA). Increased serum ATX activity has been described in patients with cholestatic pruritus ( Gastroenterology , 2010; in press).

Aim The aim of the study was to determine the effect of albumin dialysis using molecular adsorbents recirculating system (MARS) on autotaxin activity and bile salts and their relationship to the severity of pruritus.

Method 15 patients (11F/4M, PBC 10, PSC 2, other 3) with severe pruritus that was resistant to medical therapy were treated in 31 sessions (each consisting of 3, 8-h treatments; median follow-up of 12.8 months) with MARS. The intensity and severity of itch was quantified using an itch severity scale (ISS) and the visual analogue scale (VAS) pre and post treatment and then weekly for up to 12 weeks. ATX activity was measured in diluted serum samples and albumin dialysate before and after MARS treatments using a fluorescence assay. ATX protein levels were determined by Western blotting. Bile salts were measured by LCMS.

Results MARS treatment was associated with immediate, significant and complete response (R) in 11 patients, two patients had a partial response (PR) and two patients had no response (NR). Median ATX activities were not different between responders and non-responders (R=216.5; NR=306.6). A mean reduction of ATX activity of 27.6±4.13% was seen in R, 10.7±10.3% in PR and 1.5±1.48% in NR. This change in ATX activity was directly correlated with the reduction in ISS (r2=0.59; p<0.005) and VAS (r2=0.47; p<0.02). The change in serum ATX activity correlated closely with the change in serum ATX protein level (r2=0.5; p<0.01). Expectedly, no ATX activity was measureable in the albumin dialysate. ATX levels returned to pre-treatment values with relapse of itching which occurred in all responders between 6 weeks and 4 months. No significant changes in serum bile salts were observed.

Conclusion Our study suggests an important role for ATX activity in modulating the severity of pruritus in cholestatic patients providing novel insights into the pathogenesis of itch in cholestatic disease. The reduction is not due to removal of circulating ATX into the dialysate suggesting that MARS treatment either reduces the production of ATX or enhances its hepatic clearance. Alternatively, or in addition, either a substrate or co-factor of ATX is extracted by the MARS system.
Influenza A(H1N1)pdm09 in England, 2009 to 2011: a greater burden of severe illness in the year after the pandemic than in the pandemic year
Authors: O T Mytton, P D Rutter, L J Donaldson
Journal: Eurosurveillance (2012)

Influenza pandemics are often perceived as single-year events, but the burden of previous influenza pandemics has in reality been spread over a number of years. The aim of this paper is to compare the burden of influenza in the pandemic year 2009/10 with that in the year immediately after (2010/11) in England. We compared four measures of disease. There was a greater burden of severe illness in 2010/11 compared with 2009/10: more deaths (474 vs 361), more critical care admissions (2,200 vs 1,700), and more hospital admissions (8,797 vs 7,879). In contrast, there were fewer general practice consultations in 2010/11 compared with 2009/10 (370,000 vs 580,000). There was also much less public interest in influenza, as assessed by number of Google searches. This is a worrying finding, as by the time of the second influenza season, much had been learnt about the potential impact of the influenza A(H1N1)pdm09 virus and an effective vaccine developed. We suggest that a widespread assumption of 'mildness' led to insufficient ongoing action to prevent influenza and hence to avoidable influenza-related deaths. This offers a lesson to all countries, both for future influenza seasons and for pandemic preparedness planning.
DSM-III and family therapy
Authors: A Frances, J F Clarkin, S Perry
Journal: American Journal of Psychiatry (1984)

In its current form, DSM-III is of only limited value to family therapists. The authors suggest several innovations that might render future nomenclatures more useful. Axis II ratings that are interpersonal and dimensional, rather than individual and categorical, might provide important additional data for predicting and planning a family intervention. Several available family classifications suggest ways in which to derive an axis VI rating of family functioning. The authors address a number of conceptual issues that make family classification especially interesting and difficult.
Sensory-Derived Glutamate Regulates Presynaptic Inhibitory Terminals in Mouse Spinal Cord
Authors: Michael Mende, Emily V. Fletcher, Josephine L. Belluardo, Joseph P. Pierce, Praveen K. Bommareddy, Jarret A. Weinrich, Zeeba D. Kabir, Kathryn C. Schierberl, John G. Pagiazitis, Alana I. Mendelsohn, Anna Francesconi, Robert H. Edwards, Teresa A. Milner, Anjali M. Rajadhyaksha, Peter J. van Roessel, George Z. Mentis, Julia A. Kaltschmidt
Journal: Neuron (2016)
PWE-373 Volatile organic compound (VOC) profiles as indicators of early lesions in murine colon carcinogenesis
Authors: S Reade, JM Williams, DM Pritchard, CSJ Probert
Journal: Gut (2015)

<h3>Introduction</h3> Patients with inflammatory bowel disease (IBD) are at increased risk for colorectal cancer (CRC). IBD-associated CRC can be summarised as an inflammation-dysplasia-carcinoma sequence. Much effort has been spent on identifying morphologically distinctive pre-invasive mucosal lesions to help elucidate the early steps of CRC. These efforts have led to the characterisation of so-called mucin-depleted foci (MDF), formed by dysplastic crypts devoid of mucins. A metabolomics-based approach may provide a non-invasive strategy to identify volatile biomarkers of CRC, therefore improving both the early detection of CRC and patient prognosis. <h3>Method</h3> An IBD-associated CRC murine model was used. C57BL/6 female mice were housed individually and were administered one dose of 12.5mg/kg azoxymethane (AOM). Next, mice were orally exposed to 1.5% DSS for 5 days followed by 16 days ordinary water. This DSS cycle was repeated twice with animals sacrificed 12 days after final cycle. There were 2 control groups: untreated mice (<i>n = 6</i>) and mice treated with cycles of DSS alone (<i>n = 6</i>). Faecal samples were collected weekly and tissues were taken for histological analysis upon necropsy. Headspace gas surrounding samples was collected using a CAR/PDMS/DVB SPME fibre before analysis by GC-MS. Chromatograms were analysed and data were processed in-house using AMDIS and Metab. A student’s <i>t</i>-test was performed on samples collected at week 10 (<i>p &lt; 0</i>.01). A time series analysis (two-way ANOVA) was performed on samples collected at weeks 1, 4, 7 and 10, using MetATT. <h3>Results</h3> All animals treated with AOM/DSS showed signs of pre-malignancy, visualised by Alcian blue staining of colonic sections. Signs included hyperplasic and occasionally, dysplastic crypts and MDF reported by an accredited murine pathologist. Faecal VOC analysis at week 10 yielded 93 compounds, 11 of which were significantly different between the two groups (<i>p &lt; 0</i>.01). There was a significant increase in the abundance and prevalence of methyl ketones and aldehydes in treated mice and a time series analysis provided further evidence for these changes over time in VOC profiles. A PCA plot was able to clearly distinguish between untreated and treated mice based on VOCs present in the headspace of faecal samples. Furthermore, the specific compounds that were identified and differed between AOM/DSS and DSS groups may be markers of pre-malignancy. <h3>Conclusion</h3> We have shown that the early lesions of colitis-associated CRC are associated with significant metabolic alterations in the faeces of mice. Markers of chronic inflammation were found. In addition other VOCs were found in AOM/DSS treated mice which had premalignant changes in the colon. These results provide a strong rationale for future studies in humans. <h3>Disclosure of interest</h3> None Declared.
포스터발표 : 그랜드볼룸 ; 간문맥 혈전을 동반한 진행성 간세포암에서 동시 간동맥 항암-방사선 요법과 간동맥항암 단독 요법의 치료 효과 비교 (초)
Authors: 이경인, 권영란, 김윤정, 서혜진, 김은수, 장병국, 정우진, 박경식, 조광범, 황재석, 권중혁, 김진희
Journal: Clinical and Molecular Hepatology (2010)
The impact of object relations theory on psychodynamic group therapy
Authors: A Alonso, J S Rutan
Journal: American Journal of Psychiatry (1984)

Object relations theory is seen as a conceptual framework that adds to the classical Freudian structural theory. The synchrony between the two theories is manifest in psychodynamic group psychotherapy. This paper explores the convergence of these theories, emphasizing concepts from object relations theory and focusing on three major aspects as they appear in therapy groups: the evolution of the transference neurosis, group membership as a transitional phenomenon, and group therapy for the resolution of ego-syntonic character pathology. Examples of patients emerging from schizoid to paranoid and then to depressive positions of ego organization illustrate the concepts.
The Effectiveness of the Varicella Vaccine
Authors: A O Jumaan, J Seward
Journal: New England Journal of Medicine (2001)

Although varicella vaccine is given to clinically stable human immunodeficiency virus (HIV)-infected children, its effectiveness is unknown.We assessed its effectiveness by reviewing the medical records of closely monitored HIV-infected children, including those receiving highly active antiretroviral therapy (HAART) between 1989 and 2007.Varicella immunization and development of varicella or herpes zoster were noted.Effectiveness was calculated by subtracting from 1 the rate ratios for the incidence rates of varicella or herpes zoster in vaccinated versus unvaccinated children.The effectiveness of the vaccine was 82% (95% confidence interval [CI], 24%-99%;) against varicella and was 100% P p .01 (95% CI, 67%-100%;) against herpes zoster.When P !.001 the analysis was controlled for receipt of HAART, vaccination remained highly protective against herpes zoster.Human immunodeficiency virus (HIV)-infected children may develop severe varicella and are 115 times more likely than the general population to develop herpes zoster, which is often severe [1].Live attenuated varicella vaccine is safe, immunogenic, and protective against varicella-zoster virus (VZV) in-
Nutritional Deficiency Produced in the Mouse by Feeding Bentonite&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: J. Walter Wilson
Journal: JNCI Journal of the National Cancer Institute (1953)

Nutritional Deficiency Produced in the Mouse by Feeding Bentonite Get access J. Walter Wilson J. Walter Wilson Arnold Biological Laboratory, Brown University, Providence, R. I. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 1, August 1953, Pages 57–63, https://doi.org/10.1093/jnci/14.1.57 Published: 01 August 1953 Article history Received: 10 February 1953 Published: 01 August 1953
Desoxyribonucleic Acid Content of Individual Lymphoma #1 and #2 Tumor Cells as Determined by Feulgen Micro-spectrophotometry
Authors: Nicholas L. Petrakis, Lois J. Folstad
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Desoxyribonucleic Acid Content of Individual Lymphoma #1 and #2 Tumor Cells as Determined by Feulgen Micro-spectrophotometry Get access Nicholas L. Petrakis, Nicholas L. Petrakis Search for other works by this author on: Oxford Academic PubMed Google Scholar Lois J. Folstad Lois J. Folstad Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 1, August 1954, Pages 63–66, https://doi.org/10.1093/jnci/15.1.63 Published: 01 August 1954 Article history Received: 22 March 1954 Published: 01 August 1954
Intravenous Immunoglobulin as an Immunomodulating Agent in Antineutrophil Cytoplasmic Antibody–Associated Vasculitides: A French Nationwide Study of Ninety‐Two Patients
Authors: Etienne Crickx, Irène Machelart, Estibaliz Lazaro, Jean‐Emmanuel Kahn, Fleur Cohen‐Aubart, Thierry Martin, Alexandre Mania, Pierre‐Yves Hatron, Gilles Hayem, Claire Blanchard‐Delaunay, Claire de Moreuil, Guillaume Le Guenno, Frédéric Vandergheynst, François Maurier, Bruno Crestani, Robin Dhote, Nicolas Martin Silva, Yann Ollivier, Anas Mehdaoui, Bertrand Godeau, Xavier Mariette, Jacques Cadranel, Pascal Cohen, Xavier Puéchal, Claire Le Jeunne, Luc Mouthon, Loïc Guillevin, Benjamin Terrier
Journal: Arthritis & Rheumatology (2015)

Intravenous immunoglobulin (IVIG) represents a therapeutic alternative in antineutrophil cytoplasmic antibody-associated vasculitides (AAV), but its efficacy has been evaluated in only 2 small prospective trials. The aim of this study was to evaluate the efficacy and safety of IVIG in patients with AAV.We conducted a nationwide retrospective study of patients who received IVIG as immunomodulatory therapy for AAV.A total of 92 patients (mean age 51 years) presenting with either granulomatosis with polyangiitis (Wegener's) (68%), eosinophilic granulomatosis with polyangiitis (Churg-Strauss) (22%), or microscopic polyangiitis (10%) received at least 1 course of IVIG. Antineutrophil cytoplasmic antibodies were present in 72% during the flare that required IVIG, as determined by immunofluorescence assay. IVIG was initiated because of relapsing disease in 83% of cases. IVIG was given for a median of 6 months (range 1-156 months) and in combination with corticosteroids in 21% of the patients or with other immunosuppressive agents in 77%. Efficacy of IVIG was assessed in the entire population and in a subset of 34 patients with unmodified background therapy. Remission rates at 6 months were 56% in the entire population and 58% in the unmodified background therapy group. Refractory disease and treatment failure at 6 months were observed in 7% and 18% in the whole population and 3% and 21% in the unmodified background therapy group, respectively. Adverse events (AEs) occurred in 33%, including serious AEs in 12% and AEs leading to discontinuation of IVIG in 7%.This large study shows the clinical benefit of IVIG as adjunctive therapy, with an acceptable tolerance profile, and thus supports its use in AAV patients with refractory or relapsing disease.
AB1085 Empirical Approach to Investigate Raynaud's Phenomenon: The Pearl Study
Authors: R. Gualtierotti, F. Ingegnoli, A. Orenti, P. Boracchi, T. Schioppo, O. Borghi, L. Castelnuovo, V. Galbiati, C. Grossi, C. Lubatti, C. Mastaglio, S. Zeni, P.L. Meroni
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> An early diagnosis of connective tissue disease (CTD) provides a window of opportunity for monitoring and treating patients. <h3>Objectives</h3> We examined the role of history, capillaroscopy and autoantibodies to differentiate between patients with primary Raynaud9s phenomenon (RP) and secondary RP due to a CTD at their first medical evaluation. <h3>Methods</h3> One hundred fifteen consecutive adults with RP were studied. Patient profiles based on history, physical examination, capillaroscopy and laboratory investigations were examined. Logistic regression models were used in the statistical analysis. <h3>Results</h3> RP was bilateral in 92.7% of patients. The middle finger was significantly more affected. A lack of association between fingers affected by RP and fingers with capillary abnormalities was observed OR=0.75 (0.34-1.66). Fingers affected by RP with the cyanotic phase had a higher risk to have hemorrhages at capillaroscopy OR=4.46 (1.50-13.30) and giant capillaries OR=24.85 (1.48-41.74). None of the variables can discriminate between primary and secondary RP. Among these, thumb involvement and the presence of three colour phases have an OR of 1.48 and 1.85 respectively. Patients with SSc had a greater value of VAS pain (p=0.011). The presence of anti-centromere antibodies was significantly associated with a higher risk of SSc (p&lt;0.001). <h3>Conclusions</h3> Markers of a potential development of a CTD in patients with RP include: severe RP symptoms (high VAS pain), positive autoantibodies and capillary abnormalities. The presence of three colour changes and the involvement of thumb may also be a warning for secondary forms. <h3>Disclosure of Interest</h3> None declared
Case 35-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, L. Christine Oliver, Eugene J. Mark
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 29-year-old man was admitted to the hospital because of an abnormal x-ray film of the chest.The history was uncertain since the patient spoke no English. He was apparently well until three months earlier, when a cough developed; it was productive of small amounts of thick, yellow-green sputum daily, principally in the early morning, and was accompanied by anorexia, malaise, and a loss of 2 kg in weight. He felt feverish but had not taken his temperature. During the month before admission he noticed blood-streaking of sputum on two occasions. For an uncertain interval he had . . .
Response to Letter Regarding Article, “Relation of Nailfold Capillaries and Autoantibodies to Mortality in Patients With Raynaud Phenomenon”
Authors: Oliver Schlager, Markus Mueller, Jutta Gamper, Georgiana-Aura Giurgea, Silvia Charwat-Resl, Hans P. Kiener, Josef S. Smolen, Thomas Perkmann, Renate Koppensteiner, Michael E. Gschwandtner
Journal: Circulation (2016)
Elastosis Perforans Serpiginosa
Authors: M GREENBLATT
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THU0562 A Comparison Between Ankylosing Spondilitis Patients and Familial Mediterranean Fever with Ankylosing Spondilitis Patients: Table 1
Authors: A. Yazici, O. Ozdemir Isik, D. Temiz Karadag, O. Ozkul, C. Albayrak Yasar, A. Cefle
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Familial Mediterranean Fever (FMF) is autosomal ressesive disease which is commonly seen in mediterrenean countries with recurrent episodes of fever, peritonitis, pleuritis, arthritis, or erysipelas-like erythema. Some FMF patients develop sacroilitis and spondyloarthropatis. Ankylosing Spondilitis (AS) is a disease within spondyloarthritis group which is characterized by inflammation of the axial joints, peripheral oligoarthritis, and enthesitis. <h3>Objectives</h3> The aim of this study was to provide a comparison between AS patients and FMF with AS patients. <h3>Methods</h3> This study includes 360 AS patients and 44 FMF patients with AS. All cases were evaluated retrospectively, and patients9 demographic and clinical data, disease activity index, acute phase response, and their recent medications were recorded. <h3>Results</h3> Twenty seven out of 44 FMF patients with AS were female, the remaining 17 were male. The mean age was 34.5±8.6years, and the symptoms of onset show that 18 patients had serocytis, 19 patients had arthritis, 7 patients had inflammatory back pain. Out of 360 AS patients, 244 patients were male, 116 patients were female. The mean age of AS patients was 41.2±10.8 years. When all features considered, 328 patients with AS and 44 patients with FMF had inflammatory back pain, 181 patients with AS and 24 patients with FMF had hip pain, 52 patients with AS and 17 patients with FMF had peripheral arthritis, 108 patients with AS and 18 patients with FMF had heel pain, 41 patients with AS and one patients with FMF had uveitis, and 65 patients with AS and 3 patients with FMF had syndesmophyte, 80 patients with AS and 16 patients with FMF had enthesitis on the X-ray (Table 1). No statistically significant difference was observed between when AS patients and FMF patients with AS were compared, except for peripheral arthritis and syndesmofitis. <h3>Conclusions</h3> When AS patients and FMF patients with AS were compared, peripheral arthritis and enthesitis were in high frequency, but uveitis and syndesmophyte were less frequent in FMF patients with AS. To obtain scientific significance, there is a need for more results in broader study groups. <h3>References</h3> Yilmaz Ö, Kısacık B, Ozkan F, Güven G, Unlü EN, Pehlivan Y, Onat AM. Does enthesopathy relate to M694V gene mutation in patients with Familial Mediterranean fever? Clin Rheumatol. 2013;32(11):1593-8. Akkoc N, Gul A. Familial Mediterranean fever and seronegative arthritis. Curr Rheumatol Rep. 2011;13(5):388-94. <h3>Disclosure of Interest</h3> None declared