tbuckley/cabot-search huggingface dataset:
Polyglycolic acid sheet application to prevent esophageal stricture after endoscopic submucosal dissection for esophageal squamous cell carcinoma
Authors: Toshiro Iizuka, Daisuke Kikuchi, Akihiro Yamada, Shu Hoteya, Yoshiaki Kajiyama, Mitsuru Kaise
Journal: Endoscopy (2014)

<b>Background and study aim:</b> Esophageal stricture following endoscopic submucosal dissection (ESD) can be a serious complication in patients with large mucosal defects. This preliminary study examined the efficacy of using a polyglycolic acid (PGA) sheet with fibrin glue for the prevention of esophageal stricture after ESD. <b>Patients and methods:</b> A total of 15 patients were enrolled. After resection, PGA sheets were placed over the surgical wound. The size of the mucosal defect was estimated by dividing the circumference of the esophagus into 12 parts of equal size. The occurrence of esophageal stricture at 6 weeks, along with the proportion of patients who had PGA sheet remaining in place 1 week and 2 weeks after ESD, and the occurrence of adverse events were investigated. <b>Results:</b> The size of mucosal defects in the 15 patients were 7/12 (n = 4), 8 /12 (n = 5), 9/12 (n = 4), 10/12 (n = 1) and 11/12 (n = 1). Esophageal stricture occurred in 1/13 patients (7.7 %; two patients were not included in the analysis because they had required surgical resection during the follow-up period). The PGA sheet remained at 1 week after ESD in 13/15 patients (86.7 %) and at 2 weeks after ESD in 6/15 patients (40 %). No adverse events were observed. <b>Conclusion:</b> PGA sheets may have the potential to prevent esophageal stricture.
FDG PET/CT Depicts Cutaneous Plasmocytoma
Authors: Constantin Lapa, Stefan Knop, Katharina Lückerath
Journal: Clinical Nuclear Medicine (2014)

A 63-year-old man with a 1-year course of IgA-λ multiple myeloma (MM) and a history of autologous stem cell transplantation presented with multiple nontender, nodular violaceous skin lesions that were located predominantly on his trunk. Diagnostic workup using F-FDG PET/CT revealed disseminated disease including highly hypermetabolic (sub)cutaneous lesions, consistent with active manifestations of MM. Histopathology confirmed monoclonal, λ-restricted plasma cell infiltrates with a high proliferation index (Ki-67) of about 80%. Cutaneous manifestation of MM is an uncommon observation in clinical practice portending poor prognosis.
An analysis of endoscopy-assisted and laparoscopic intragastric surgery in an experimental model of gastric submucosal pseudotumor
Authors: FM Sánchez-Margallo, FJ Pérez, MA Sánchez
Journal: Endoscopy (2012)

Objective: This study aimed to evaluate the feasibility and usefulness of the combination of flexible endoscopy and laparoscopy during minimally invasive intragastric treatment of experimental submucosal pseudotumors located at the level of Z-line.
Effect on Blood Lipids of Very High Intakes of Fiber in Diets Low in Saturated Fat and Cholesterol
Authors: David Jenkins, Thomas Wolever, A. Venketeshwer Rao, Robert A. Hegele, Steven J. Mitchell, Thomas Ransom, Dana L. Boctor, Peter J. Spadafora, Alexandra L. Jenkins, Christine Mehling, Lisa Katzman Relle, Philip W. Connelly, Jon A. Story, Emily J. Furumoto, Paul Corey, Pierre Wursch
Journal: New England Journal of Medicine (1993)

It is known that soluble fiber in the diet can lower blood lipid levels. It is less certain, however, that eating foods with soluble fiber will further lower blood lipids when the intake of saturated fat and cholesterol has already been reduced to very low levels. Furthermore, the mechanism of the lipid-lowering effect of fiber has not been elucidated.
Scrub Typhus after a Trip to Vietnam
Authors: Marie Marthe Thiebaut, François Bricaire, Didier Raoult
Journal: New England Journal of Medicine (1997)

To the Editor: Roach et al. report a cumulative incidence of 6.1 percent for cerebral complications after coronaryartery bypass grafting.The incidence of focal or more serious (type I) outcomes was five times as high in patients with a palpable atherosclerotic plaque in the proximal aor-The New England Journal of Medicine Downloaded from nejm.
355 POLYCYSTIC HUMAN CHOLANGIOCYTES SHOW INCREASED MATRIX-METALLOPROTEASE ACTIVITY STIMULATED BY INTERLEUKIN-6, INTERLEUKIN-8 AND ESTROGENS
Authors: A.D. Urribarri, S. Sárvide, E. Saez, A. Portu, J.P. Jimeno, T. Masyuk, J. Prieto, N.F. LaRusso, J.M. Banales
Journal: Journal of Hepatology (2012)
A THREE-ZONE PARTITION FOR PULMONARY ARTERY DIMENSIONS MEASURED BY COMPUTED TOMOGRAPHY TO “RULE IN” AND “RULE OUT” PULMONARY HYPERTENSION
Authors: Asim Rizvi, Qing Zhou, Zachary R. Lavender, Roderick Deano, James Min, Rajeev Malhotra, Quynh Truong
Journal: Journal of the American College of Cardiology (2015)
Abstract 949: PathSeq: A comprehensive computational tool for pathogen discovery by deep sequencing of human cancer tissues
Authors: Akinyemi I. Ojesina, Aleksandar Kostic, Chandra Sekhar Pedamallu, Joonil Jung, Fujiko Duke, Gad Getz, Matthew Meyerson
Journal: Cancer Research (2011)

Abstract BACKGROUND: It is thought that pathogens cause a significant fraction of human cancers. However, many of these pathogens are unknown. Our project is based on the premise that if a cancer is caused by a microbial infection, the cancer tissue should contain both human and microbial DNA/RNA. High throughput sequencing, followed by computational subtraction of human reads should then yield non-human candidate sequences for further validation. METHODS: We have developed an integrated pathogen discovery process to address this need. cDNA libraries are generated from tumor tissues and subjected to high-throughput Illumina sequencing to generate 30-60 million sequence reads per sample. Quality filtered reads are analyzed using our automated pipeline, PathSeq, comprising several subtraction steps: i) aligning to human sequence databases; ii) aligning to other vertebrate sequence databases; iii) filtering for low-complexity reads; iv) aligning using BLAST to genome databases; and v) de novo assembly and searching against microbial databases. RESULTS: We have generated and analyzed both transcriptome and whole genome sequencing data across several cancers, and have identified microbial sequences in both frozen and formalin-fixed paraffin-embedded (FFPE) tissues. The details will be presented during the meeting. CONCLUSION: The PathSeq software package is implemented in a cloud-computing environment and is available for public use. It therefore has the potential to make pathogen discovery accessible to any researcher with access to human deep sequencing data. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 949. doi:10.1158/1538-7445.AM2011-949
Abstract 3351: Cord blood stem cells inhibit epidermal growth factor receptor translocation to mitochondria in glioblastoma
Authors: Venkata Ramesh Dasari, Kiran Kumar Velpula, Kiranmai Alapati, Meena Gujrati, Andrew J. Tsung
Journal: Cancer Research (2012)

Abstract Overexpression of EGFR is one of the most frequently diagnosed genetic aberrations of glioblastoma multiforme (GBM). EGFR signaling is involved in diverse cellular functions and is dependent on the type of preferred receptor complexes. EGFR translocation to mitochondria has been reported recently in different cancer types. However, mechanistic aspects of EGFR translocation to mitochondria in GBM have not been evaluated to date. In the present study, we analyzed the expression of EGFR in GBM-patient derived specimens using immunohistochemistry, reverse-transcription based PCR and Western blotting techniques. In clinical samples, EGFR co-localizes with FAK in mitochondria. We evaluated this previous observation in standard glioma cell lines and in vivo mice xenografts. We further analyzed the effect of human umbilical cord blood stem cells (hUCBSC) on the inhibition of EGFR expression and EGFR signaling in glioma cells and xenografts. Treatment with hUCBSC inhibited the expression of EGFR and its co-localization with FAK in glioma cells. Also, hUCBSC inhibited the co-localization of activated forms of EGFR, FAK and c-Src in mitochondria of glioma cells and xenografts. In addition, hUCBSC also inhibited EGFR signaling mechanisms in glioma cells both in vitro and in vivo. We have shown that hUCBSC treatments inhibit phosphorylation of EGFR, FAK and c-Src forms. Our findings associate EGFR expression and its localization to mitochondria with specific biological functions in GBM cells and provide relevant preclinical information that can be used for the development of effective hUCBSC-based therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3351. doi:1538-7445.AM2012-3351
Massive Gas-Bacillus Infection of the Liver after Surgical Exploration of a Stenotic Biliary Anastomosis
Authors: Albert G. Mackay, Edgar J. Caldwell, Ruhi K. Hindawi
Journal: New England Journal of Medicine (1963)

GAS-bacillus infection of the biliary tract after surgery is a relatively rare occurrence and is stated by Adams1 to have occurred in his experience three times in 4221 operations on the biliary tract. Various authors have disagreed about the incidence of other types of infection in the biliary tract. Mirizzi2 studied the bacteriology of the common bile duct and found it to be sterile in most cases. Twiss3 was able to obtain positive cultures of different bacteria from the duodenum in 28 of 120 patients and later verified at operation the fact that all these patients showed stones. Zollinger and . . .
Abstract P4-04-05: Histone Deacetylase Inhibitors Increase Markers of the Dedifferentiated Cancer Stem Cell Phenotype in Human Breast Cancer Cells
Authors: BG Debeb, W Xu, L Lacerda, GN Hortobagyi, F Robertson, NN Ueno, A Lucci, JM Reuben, TA Buchholz, WA. Woodward
Journal: Cancer Research (2010)

Abstract It has been suggested that differentiated cancer cells can de-differentiate into the cancer stem cell phenotype (Meyers et al., 2009; Gupta et al., 2009) and that Histone Deacetylase (HDAC) inhibitors enable efficient induction of pluripotent stem cells from adult fibroblasts (Huangfu et al., 2009). Moreover, we have recently demonstrated that the HDAC inhibitor valproic acid radiosensitized breast cancer cells grown on plastic with serum while it radioprotected breast cancer cells grown in stem cell promoting culture conditions (Debeb et al., 2010). Based on these data, we hypothesized that HDAC inhibitors increase the cancer stem cell population via dedifferentiation of differentiated cancer cells. To examine our hypothesis, Sum159 breast cancer cells were FACS-sorted based on ALDH activity and subsequently treated with one of two HDAC inhibitors, valproic acid or SAHA (suberoylanilide hydroxamic acid). After sorting, ALDH-negative cells were treated either with valproic acid, SAHA, or vehicle. After a week, the percentage of ALDH-positive cells (passage 0, P0) was examined with flow cytometry while the remaining cells were passaged and incubated with and without valproic acid or SAHA for a week and the percentage of ALDH-positive cells again evaluated (P1). This was repeated for the third time (P2). Samples from each generation were also collected to examine the protein expression. On average, a 3-fold increase in ALDH positive cells was seen in valproic acid-treated cells (35.6% vs.12.6%) and a 1.5-fold increase in SAHA-treated cells (41% vs. 28%) compared to vehicle-treated controls. This effect was maintained through multiple passages. Moreover, the expression of Beta-catenin and EMT associated genes like vimentin, fibronectin, n-cadherin, which have been implicated in generating cancer stem cells was significantly increased withtreatment in initial and passaged cells. Further functional endpoint studies are needed to validate these in vitro marker-based findings. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P4-04-05.
Relation between Malpractice Claims and Adverse Events Due to Negligence
Authors: A. Russell Localio, Ann G. Lawthers, Troyen A. Brennan, Nan M. Laird, Liesi E. Hebert, Lynn M. Peterson, Joseph P. Newhouse, Paul C. Weiler, Howard H. Hiatt
Journal: New England Journal of Medicine (1991)

By matching the medical records of a random sample of 31,429 patients hospitalized in New York State in 1984 with statewide data on medical-malpractice claims, we identified patients who had filed claims against physicians and hospitals. These results were then compared with our findings, based on a review of the same medical records, regarding the incidence of injuries to patients caused by medical management (adverse events).
Late Breaking News: Breast Cancer Coalition Demands Attention
Authors: D. A. Tisevich
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Late Breaking News : Breast Cancer Coalition Demands Attention Get access Dorothy A. Tisevich Dorothy A. Tisevich Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Page 756, https://doi.org/10.1093/jnci/83.11.756 Published: 05 June 1991
Abstract 4204: Impact of Left Ventricular Diastolic Functional Reserve on Clinical Outcome in Patients with Diabetes Mellitus
Authors: Sung Ai Kim, Sang Jae Rhee, Chi-Young Shim, Sungha Park, Donghoon Choi, Eui-Young Choi, Namsik Chung, Jong-Won Ha
Journal: Circulation (2008)

Left ventricular (LV) longitudinal diastolic functional reserve, assessed by the change of early diastolic mitral annular velocity (E′) during exercise, is abnormal in patients with diabetes without overt heart disease. However, its impact on clinical outcome has not been explored previously. We hypothesized that LV diastolic reserve could further stratify diastolic dysfunction, and have a prognostic significance in patients with diabetes. Of 1,170 patients who were referred for diastolic stress echocardiography, 227 consecutive patients (mean age 58 years, male 103, mean ejection fraction [EF] 68 %) with diabetes were identified. LV diastolic function reserve index (DFRI) was calculated as E′ base x ΔE′; where ΔE′ is the change of E′ from baseline to exercise. The primary end-point was a composite of all-cause death and re-hospitalization for heart failure. The median follow-up duration was 34 months, and the primary end-point was occurred in 14 (6.1%) of 227 patients. Among the predictors that showed a significance in the univariate Cox analysis, including age, coronary artery disease history, renal insufficiency, LV mass index, LAVI, and EF, LV DFRI was the most independent predictor of adverse outcomes. When patients were classified by the median value of DFRI at 50W of exercise, patients with DFRI &lt; 13.5 showed poorer clinical outcomes compared to those with DFRI ≥ 13.5 (p=0.001). The assessment of LV diastolic functional reserve using exercise Doppler echocardiography is helpful in further stratifying diastolic dysfunction, and provides incremental prognostic information in patients with diabetes without overt heart disease.
Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors
Authors: Gao Zhang, Dennie T. Frederick, Lawrence Wu, Zhi Wei, Clemens Krepler, Satish Srinivasan, Young Chan Chae, Xiaowei Xu, Harry Choi, Elaida Dimwamwa, Omotayo Ope, Batool Shannan, Devraj Basu, Dongmei Zhang, Manti Guha, Min Xiao, Sergio Randell, Katrin Sproesser, Wei Xu, Jephrey Liu, Giorgos C. Karakousis, Lynn M. Schuchter, Tara C. Gangadhar, Ravi K. Amaravadi, Mengnan Gu, Caiyue Xu, Abheek Ghosh, Weiting Xu, Tian Tian, Jie Zhang, Shijie Zha, Qin Liu, Patricia Brafford, Ashani Weeraratna, Michael A. Davies, Jennifer A. Wargo, Narayan G. Avadhani, Yiling Lu, Gordon B. Mills, Dario C. Altieri, Keith T. Flaherty, Meenhard Herlyn
Journal: Journal of Clinical Investigation (2016)

Targeting multiple components of the MAPK pathway can prolong the survival of patients with BRAFV600E melanoma. This approach is not curative, as some BRAF-mutated melanoma cells are intrinsically resistant to MAPK inhibitors (MAPKi). At the systemic level, our knowledge of how signaling pathways underlie drug resistance needs to be further expanded. Here, we have shown that intrinsically resistant BRAF-mutated melanoma cells with a low basal level of mitochondrial biogenesis depend on this process to survive MAPKi. Intrinsically resistant cells exploited an integrated stress response, exhibited an increase in mitochondrial DNA content, and required oxidative phosphorylation to meet their bioenergetic needs. We determined that intrinsically resistant cells rely on the genes encoding TFAM, which controls mitochondrial genome replication and transcription, and TRAP1, which regulates mitochondrial protein folding. Therefore, we targeted mitochondrial biogenesis with a mitochondrium-targeted, small-molecule HSP90 inhibitor (Gamitrinib), which eradicated intrinsically resistant cells and augmented the efficacy of MAPKi by inducing mitochondrial dysfunction and inhibiting tumor bioenergetics. A subset of tumor biopsies from patients with disease progression despite MAPKi treatment showed increased mitochondrial biogenesis and tumor bioenergetics. A subset of acquired drug-resistant melanoma cell lines was sensitive to Gamitrinib. Our study establishes mitochondrial biogenesis, coupled with aberrant tumor bioenergetics, as a potential therapy escape mechanism and paves the way for a rationale-based combinatorial strategy to improve the efficacy of MAPKi.
AB0896 Characteristics of Systemic Sclerosis and Localized Scleroderma in Children and Adolescents
Authors: I. Chyzheuskaya, L. Belyaeva
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Systemic sclerosis (SS) is a connective tissue disease with inflammation, fibrosis and vascular damage. Early diagnosis may be difficult if disease expression is oligosymptomatic, presenting with only Raynaud9s phenomenon or limited scleroderma (LS). <h3>Methods</h3> The study group included 65 children and adolescents: 24 patients with SS and 41 patients with LS. Mean age was 12,7 years (SD±0,56) in patients with SS and 13 years (SD ±0,73) in patients with LS. Mean disease duration was 4,9 years (SD±0,81) in patients with SS and 5,1 years (SD ±0,42) in patients with LS. <h3>Results</h3> Similar immunologic abnormalities in patients with SS and LS revealed. Pulmonary function testing documented restrictive ventilatory defect in 33,3% children and adolescents with SS and in 31,7% patients with LS. Alteration of gastrointestinal tract detected in 91,7% patients with SS and in 63,8% patients with LS. Inflammation of mucous of stomach and esophagus has mostly light degree of manifestation, low degree of activity and absence of Helicobacter pylori (60% patients with SS and 50% patients with LS). Repeatability of visceral changes as well as similar morphological character in skin lesion focuses in children and adolescents with SS and LS established. <h3>Conclusions</h3> Evidence of common mechanisms of pathogenesis for systemic sclerosis and localized scleroderma is given. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3825
Renal Accumulation of Tc-99m Albumin Colloid in a Patient With Multiple Cardiovascular Events
Authors: J D Slavin, I O Engin, R P Spencer
Journal: Clinical Nuclear Medicine (1998)

A 52-year-old man with dilated cardiomyopathy, congestive heart failure, and a history of cardiovascular events, underwent a liver scan with Tc-99m-albumin colloid. There was diminished hepatic uptake, with a shift of activity to the spleen and bone marrow. In addition, accumulation in both kidneys was noted. Reports on renal uptake of the related compound Tc-99m-sulfur colloid were reviewed. A common mechanism of deposition may involve intravascular fibrin deposition.
FRI0214 Eular Project: Spondyloarthritis Prevalence in Serbia
Authors: M.I. Zlatkovic-Svenda, R.M. Stojanovic, S.B. Grujicic-Sipetic, F. Guillemin
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> There is a need to enable comparable spondyloarthropathy (SpA) prevalence estimates in Europe, which was made possible by the unique European EULAR project methodology <h3>Objectives</h3> to estimate the SpA prevalence in Serbia, as part of the EULAR study <h3>Methods</h3> In a detection phase, a previously translated and validated telephone Questionnaire comprising of signs, symptoms and self-reported diagnosis (1) was used by 30 lay interviewers on a representative sample of 6213 randomly selected telephone numbers (every 100-th), from urban Serbian population: Belgrade (north) and Cacak, Uzice and Krusevac (south). Suspected cases have received a second call by a rheumatologist. In a confirmation phase, for patients with self-reported diagnosis and positive symptoms patient9s rheumatologist was contacted to confirm diagnosis; a complete rheumatologist examination was arranged for those with positive symptoms only. Prevalence estimates were standardised for age and sex with relation to Serbian population (census 2002). <h3>Results</h3> The response rate was 63,6% (3950 respondents). Second call was received by 571 people, among whom 16 SpA cases were confirmed (11 diagnosed previously and 5 newly-diagnosed during the rheumatology examination). The Serbian standardized SpA prevalence was 0,32% (95% confidence interval-CI: 0,14-0,50), it was 0,34% (95% CI 0,04-0,64) for men and 0,31% (95% CI: 0,09-0,53) for women. The prevalence for ankylosing spondylitis was 0,08% (95% CI 0,03-0,13), for psoriatic arthritis 0,09% (95% CI 0,03-0,15), for reactive arthritis (morbus Reiter) 0,10% (95% CI 0,04-0,16), for enteropathic arthritis (associated with inflammatory bowel diseases) 0,03% (95% CI 0,00-0,06) and for undifferentiated spondyloarthropathy 0,02% (95% CI 0,00-0,05). <h3>Conclusions</h3> Compared to prevalence studies using the same methodology and design, SpA prevalence estimates in Serbia are close to France (2), but lower than those reported from Lithuania (3). <h3>References</h3> Zlatkovic-Svenda MI, Stojanovic RM, Milenkovic MP, Vlajinac HD, Le Bihan E, Guillemin F. Adaptation and validation of a telephone questionnaire – Serbian version for case detection of rheumatoid arthritis and spondyloarthropathy (multicentric Eular study). Clin Exp Rheumatol. 2007; 25 (1): 75-84. Saraux A, Guillemin F, Guggenbuhl P, Roux CH, Fardellone P, Le Bihan E, et al. Prevalence of spondyloarthropathies in France: 2001. Ann Rheum Dis. 2005 Oct;64(10):1431–35. Adomaviciute D, Pileckyte M, Baranauskaite A, Morvan J, Dadoniene J, Guillemin F. Prevalence survey of rheumatoid arthritis and spondyloarthropathy in Lithuania. Scand J Rheumatol. 2008 Mar-Apr;37(2):113–9. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3592
154 PREVALENCE OF ADENOMATOUS COLON POLYPS AFTER LIVER TRANSPLANTATION (LT): THE LEVEL OF IMMUNOSUPPRESSION MAKES THE DIFFERENCE
Authors: G. Danan, S. Faure, Y. Duny, E. Assenat, R. Altwegg, M. Bismuth, A. Herrero, F. Navarro, D. Larrey, G.-P. Pageaux
Journal: Journal of Hepatology (2013)
Endoscopic tissue shielding to prevent delayed perforation associated with endoscopic submucosal dissection for duodenal neoplasms
Authors: K. Takimoto, T. Toyonaga, K. Matsuyama
Journal: Endoscopy (2012)

In Japan, endoscopic submucosal dissection (ESD) is increasingly performed for gastrointestinal neoplasms. However, ESD has not been widely applied to duodenal neoplasms. Postoperative delayed perforation occurs frequently because of exposure of pancreatic juice to the duodenum [1]. Regarding the closure technique after ESD, the usefulness of clip closure has been reported [2], but we encountered many cases of difficult clip closure for large mucosal defects. We considered that polyglycolic acid (PGA) sheets (Neoveil; Gunze Co., Kyoto, Japan) and fibrin glue (Beriplast P combi-set; CSL Behring Pharma, Tokyo, Japan) might be useful.