tbuckley/cabot-search huggingface dataset:
Phase II study of imatinib-based chemotherapy for newly diagnosed <i>BCR-ABL-</i> positive acute lymphoblastic leukemia
Authors: Shin Fujisawa, Shuichi Mizuta, Hideki Akiyama, Yasunori Ueda, Yasutaka Aoyama, Yoshihiro Hatta, Kazuhiko Kakihana, Nobuaki Dobashi, Isamu Sugiura, Yasushi Onishi, Tomoya Maeda, Kiyotoshi Imai, Shigeki Ohtake, Yasushi Miyazaki, Kazunori Ohnishi, Keitaro Matsuo, Tomoki Naoe
Journal: American Journal of Hematology (2017)

Abstract This study investigated the efficacy of imatinib based therapy with intensified consolidation therapy in patients with Philadelphia chromosome (Ph)‐positive acute lymphoblastic leukemia (ALL) to prevent early relapse. We conducted a phase II trial of imatinib‐combined chemotherapy for newly diagnosed BCR‐ABL‐positive ALL in adults. Sixty‐eight patients were included in the trial between October 2008 and December 2010. The median age was 49 years, with 28 patients &gt;55 years of age. Sixty‐five patients achieved CR (95.6%). The estimated 2‐year event‐free survival (EFS) and overall survival (OS) were 62.3% and 67.4%, respectively. Allogeneic stem cell transplantation (allo‐SCT) at initial CR was performed in 43 patients. Thirty‐five of 39 patients &lt;55 years and 8 of 26 patients &gt;55 years underwent allo‐SCT at first CR. The 3‐year OS in patients &lt;55 years receiving allo‐SCT at first CR, patients &gt;55 years receiving allo‐SCT at first CR, patients &lt;55 years not receiving allo‐SCT at first CR, and patients &gt;55 years not receiving allo‐SCT at first CR were 80.4%, 41.1%, 32.5%, and 52.0%, respectively ( P = 0.058). The three‐year EFS in each group was 76.7%, 53.6%, not reached, and 26.4%, respectively ( P = 0.150). A high CR rate was observed with imatinib‐based chemotherapy allowing allo‐SCT in a high proportion of patients, particularly those &lt;55 years. Moreover, intensified consolidation therapy reduced early relapse rates following induction therapy and resulted in improved OS and EFS rates following allo‐SCT. This trial was registered with the UMIN (000001226).
Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome
Authors: Agata Wesolowska-Andersen, Jamie L. Everman, Rebecca Davidson, Cydney Rios, Rachelle Herrin, Celeste Eng, William J. Janssen, Andrew H. Liu, Sam S. Oh, Rajesh Kumar, Tasha E. Fingerlin, Jose Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold
Journal: Genome biology (2017)

Respiratory illness caused by viral infection is associated with the development and exacerbation of childhood asthma. Little is known about the effects of respiratory viral infections in the absence of illness. Using quantitative PCR (qPCR) for common respiratory viruses and for two genes known to be highly upregulated in viral infections (CCL8/CXCL11), we screened 92 asthmatic and 69 healthy children without illness for respiratory virus infections. We found 21 viral qPCR-positive and 2 suspected virus-infected subjects with high expression of CCL8/CXCL11. We applied a dual RNA-seq workflow to these subjects, together with 25 viral qPCR-negative subjects, to compare qPCR with sequencing-based virus detection and to generate the airway transcriptome for analysis. RNA-seq virus detection achieved 86% sensitivity when compared to qPCR-based screening. We detected additional respiratory viruses in the two CCL8/CXCL11-high subjects and in two of the qPCR-negative subjects. Viral read counts varied widely and were used to stratify subjects into Virus-High and Virus-Low groups. Examination of the host airway transcriptome found that the Virus-High group was characterized by immune cell airway infiltration, downregulation of cilia genes, and dampening of type 2 inflammation. Even the Virus-Low group was differentiated from the No-Virus group by 100 genes, some involved in eIF2 signaling. Respiratory virus infection without illness is not innocuous but may determine the airway function of these subjects by driving immune cell airway infiltration, cellular remodeling, and alteration of asthmogenic gene expression.
Combined VBM Chemotherapy and Involved Field (IF) Radiotherapy in Early Stage Hodgkin’s Lymphoma (HL): A Single Centre Experience.
Authors: Emilia Cocorocchio, Fedro A. Peccatori, Federica Gigli, Simona Bassi, Luca Nassi, Liliana Calabrese, Laura Travaini, Gaia Piperno, Lorenzo Preda, Giancarlo Pruneri, Sarah J. Liptrott, Alessandra Alietti, Giovanni Martinelli
Journal: Blood (2007)
An endoplasmic reticulum protein, Nogo‐B, facilitates alcoholic liver disease through regulation of kupffer cell polarization
Authors: Jin‐Kyu Park, Mingjie Shao, Moon Young Kim, Soon Koo Baik, Mee Yon Cho, Teruo Utsumi, Ayano Satoh, Xinsho Ouyang, Chuhan Chung, Yasuko Iwakiri
Journal: Hepatology (2017)

Nogo‐B (Reticulon 4B) is an endoplasmic reticulum (ER) resident protein that regulates ER structure and function. Because ER stress is known to induce M2 macrophage polarization, we examined whether Nogo‐B regulates M1/M2 polarization of Kupffer cells and alters the pathogenesis of alcoholic liver disease (ALD). M1 and M2 phenotypes were assessed in relation to Nogo‐B expression and disease severity in liver specimens from ALD patients (NCT01875211). Liver specimens from wild‐type (WT) and Nogo‐B knockout (KO) mice fed a control or Lieber‐DeCarli ethanol liquid diet (5% ethanol) for 6 weeks were analyzed for liver injury and steatosis. Kupffer cells isolated from WT and Nogo‐B KO mice were assessed for M1 and M2 activation. A significant positive correlation was observed between Nogo‐B positive Kupffer cells and disease severity in ALD patients (n = 30, r = 0.66, P = 0.048). Furthermore, Nogo‐B–positive Kupffer cells were correlated with M1 activation (inducible nitric oxide synthase) ( r = 0.50, P = 0.05) and negatively with markers of M2 status (CD163) ( r = −0.48, P = 0.07) in these patients. WT mice exhibited significantly increased liver injury ( P &lt; 0.05) and higher hepatic triglyceride levels ( P &lt; 0.01) compared with Nogo‐B KO mice in response to chronic ethanol feeding. Nogo‐B in Kupffer cells promoted M1 polarization, whereas absence of Nogo‐B increased ER stress and M2 polarization in Kupffer cells. Conclusion : Nogo‐B is permissive of M1 polarization of Kupffer cells, thereby accentuating liver injury in ALD in humans and mice. Nogo‐B in Kupffer cells may represent a new therapeutic target for ALD. (H epatology 2017;65:1720‐1734).
Peri-Engraftment Mucositis Amongst Patients Receiving Intravenous Busulfan/Fludarabine as Conditioning Regimen for Allogeneic Hemopoietic Stem Cell Transplantation.
Authors: Abhinav Deol, Palaniappan Manickam, Joseph Uberti, Voravit Ratanatharathorn, Lawrence G. Lum, Lois Ayash, Muneer H. Abidi, Judith Abrams, Zaid Al-Kadhimi
Journal: Blood (2009)
Embolic events in patients with atrial fibrillation and effective anticoagulation: value of transesophageal echocardiography to guide direct-current cardioversion
Authors: Karlheinz Seidl, Monika Rameken, Axel Drögemüller, Margit Vater, Andreas Brandt, Harald Schwacke, Caroline Bergmeier, Ralf Zahn, Jochen Senges
Journal: Journal of the American College of Cardiology (2002)
Factors Affecting the Results of Allogeneic Hematopoietic Stem Cell Transplantation in Hematologic Malignancies
Authors: J. Mehta, O. Frankfurt, J. Altman, Andrew M Evens, L. Gordon, M. Tallman, S. Williams, J. Winter, J. Krishnamurthy, D. Grinblatt, L. Kaminer, S. Singhal
Journal: Blood (2008)
Genome-wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions
Authors: Josyf C. Mychaleckyj, Alexandre Havt, Uma Nayak, Relana Pinkerton, Emily Farber, Patrick Concannon, Aldo A. Lima, Richard L. Guerrant
Journal: Molecular Biology and Evolution (2016)

Despite its population, geographic size, and emerging economic importance, disproportionately little genome-scale research exists into genetic factors that predispose Brazilians to disease, or the population genetics of risk. After identification of suitable proxy populations and careful analysis of tri-continental admixture in 1,538 North-Eastern Brazilians to estimate individual ancestry and ancestral allele frequencies, we computed 400,000 genome-wide locus-specific branch length (LSBL) Fst statistics of Brazilian Amerindian ancestry compared to European and African; and a similar set of differentiation statistics for their Amerindian component compared with the closest Asian 1000 Genomes population (surprisingly, Bengalis in Bangladesh). After ranking SNPs by these statistics, we identified the top 10 highly differentiated SNPs in five genome regions in the LSBL tests of Brazilian Amerindian ancestry compared to European and African; and the top 10 SNPs in eight regions comparing their Amerindian component to the closest Asian 1000 Genomes population. We found SNPs within or proximal to the genes CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch, while SNPs in the genes ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) were most highly differentiated in the Asian comparison. These genes are known to influence immune function, metabolic and anthropometry traits, and embryonic development. These analyses have identified candidate genes for selection within Amerindian ancestry, and by comparison of the two analyses, those for which the differentiation may have arisen during the migration from Asia to the Americas.
Poor Outcome of Allogeneic Bone Marrow Transplantation Recipients Requiring Mechanical Ventilation: Should We Restrict Intensive Care Support?.
Authors: Cécile Aubron, Elie Azoulay, François Blot, Jean-Paul Mira, Guillaume Thiery, Bruno Raynard, Agnes Buzyn, Gérard Socié, Philippe Arnaud, Frédéric Pene
Journal: Blood (2004)
Platelet Aggregation Is Inhibited by Nitrite Reduction to Nitric Oxide In Blood
Authors: Alan N. Schechter, Sirada Srihirun, Thanaporn Sriwantana, Supeenun Unchern, Egarit Noulsri, Kovit Pattanapanyasat, Suthat Fucharoen, Barbora Piknova, Nathawut Sibmooh
Journal: Blood (2010)
Prospective, Randomized, Multicenter Phase III, Polish Adult Leukemia Group (PALG) Study Comparing DAF (DNR+AraC+Fludarabine), DAC (DNR+AraC+Cladribine), and Standard DA Regimen in Induction of Untreated Acute Myeloid Leukemia Patients - First Report.
Authors: Jerzy Holowiecki, Sebastian Grosicki, Slawomira Kyrcz-Krzemien, Janusz Kloczko, Kazimierz Sulek, Andrzej Hellmann, Aleksander Skotnicki, Kazimierz Kuliczkowski, Krystyna Zawilska, Tadeusz Robak, Anna Dmoszynska, Krzysztof Warzocha
Journal: Blood (2005)
How cognition affects perception: Brain activity modelling to unravel top-down dynamics
Authors: Martin Desseilles, Christophe Phillips
Journal: Behavioral and Brain Sciences (2016)

Abstract In this commentary on Firestone &amp; Scholl's (F&amp;S's) article, we argue that researchers should use brain-activity modelling to investigate top-down mechanisms. Using functional brain imaging and a specific cognitive paradigm, modelling the BOLD signal provided new insight into the dynamic causalities involved in the influence of cognitions on perceptions.
Probiotics, D–Lactic acidosis, oxidative stress and strain specificity
Authors: Luis Vitetta, Samantha Coulson, Michael Thomsen, Tony Nguyen, Sean Hall
Journal: Gut Microbes (2017)

The existence of an implicit living microscopic world, composed primarily of bacteria, has been known for centuries. The exact mechanisms that govern the contribution of bacteria to human health and disease have only recently become the subject of intense research efforts. Within this very evident shift in paradigms, the rational design of probiotic formulations has led to the creation of an industry that seeks to progress the engineering of probiotic bacteria that produce metabolites that may enhance human host health and prevent disease. The promotion of probiotics is often made in the absence of quality scientific and clinically plausible data. The latest incursions into the probiotic market of claims have posited the amelioration of oxidative stress via potent antioxidant attributes or limiting the administration of probiotics to those species that do not produce D-Lactic acid (i.e., claims that D-Lactic acid acidosis is linked to chronic health conditions) or are strain-specific (shaping an industry point of difference) for appraising a therapeutic effect. Evidence-based research should guide clinical practice, as there is no place in science and medicine that supports unsubstantiated claims. Extravagant industry based notions continue to fuel the imprimatur of distrust and skepticism that is leveled by scientists and clinicians at an industry that is already rife with scientific and medical distrust and questionable views on probiotics. Ignoring scientifically discordant data, when sorting through research innovations and false leads relevant to the actions of probiotics, drives researcher discomfit and keeps the bar low, impeding the progress of knowledge. Biologically plausible posits are obligatory in any research effort; companies formulating probiotics often exhibit a lack of analytical understanding that then fuels questionable investigations failing to build on research capacity.
A Phase II Study of Temozolomide Therapy for Poor Risk Patients Age ≥ 60 Years with Acute Myeloid Leukemia (AML) - Low Levels of MGMT May Predict for Response.
Authors: Joseph M. Brandwein, Aaron D. Schimmer, Andre C. Schuh, Vikas Gupta, Richard A. Wells, Lin Yang, Mark D. Minden
Journal: Blood (2005)
Efficacy of Dasatinib in Patients with Chronic Phase Philadelphia Chromosome-Positive CML Resistant or Intolerant to Imatinib: First Results of the CA180013 ‘START-C’ Phase II Study.
Authors: Andreas Hochhaus, M. Baccarani, C. Sawyers, A. Nagler, T. Facon, S.L. Goldberg, F. Cervantes, R.A. Larson, M. Voi, R. Ezzeddine, H. Kantarjian
Journal: Blood (2005)
The Synonymous V107V Mutation In Factor IX Is Not So Silent and May Cause Hemophilia B In Patients
Authors: Chava Kimchi-Sarfaty, Vijaya L Simhadri, David Kopelman, Adam Friedman, Nathan Edwards, Atiq Javaid, Chinyere Okunji, Anton Komar, Zuben Sauna, Nobuko Katagiri
Journal: Blood (2010)
Antileukemia Efficacy and Mechanisms of Action of SL-101, a Novel Anti-CD123 Antibody Conjugate, in Acute Myeloid Leukemia
Authors: Lina Han, Jeffrey L. Jorgensen, Chris Brooks, Ce Shi, Qi Zhang, Graciela M. Nogueras González, Antonio Cavazos, Rongqing Pan, Hong Mu, Sa A. Wang, Jin Zhou, Gheath AI-Atrash, Stefan O. Ciurea, Mike Rettig, John F. DiPersio, Jorge Cortes, Xuelin Huang, Hagop M. Kantarjian, Michael Andreeff, Farhad Ravandi, Marina Konopleva
Journal: Clinical Cancer Research (2017)

Abstract Purpose: The persistence of leukemia stem cells (LSC)-containing cells after induction therapy may contribute to minimal residual disease (MRD) and relapse in acute myeloid leukemia (AML). We investigated the clinical relevance of CD34+CD123+ LSC-containing cells and antileukemia potency of a novel antibody conjugate SL-101 in targeting CD123+ LSCs. Experimental Methods and Results: In a retrospective study on 86 newly diagnosed AML patients, we demonstrated that a higher proportion of CD34+CD123+ LSC-containing cells in remission was associated with persistent MRD and predicted shorter relapse-free survival in patients with poor-risk cytogenetics. Using flow cytometry, we explored the potential benefit of therapeutic targeting of CD34+CD38−CD123+ cells by SL-101, a novel antibody conjugate comprising an anti-CD123 single-chain Fv fused to Pseudomonas exotoxin A. The antileukemia potency of SL-101 was determined by the expression levels of CD123 antigen in a panel of AML cell lines. Colony-forming assay established that SL-101 strongly and selectively suppressed the function of leukemic progenitors while sparing normal counterparts. The internalization, protein synthesis inhibition, and flow cytometry assays revealed the mechanisms underlying the cytotoxic activities of SL-101 involved rapid and efficient internalization of antibody, sustained inhibition of protein synthesis, induction of apoptosis, and blockade of IL3-induced p-STAT5 and p-AKT signaling pathways. In a patient-derived xenograft model using NSG mice, the repopulating capacity of LSCs pretreated with SL-101 in vitro was significantly impaired. Conclusions: Our data define the mechanisms by which SL-101 targets AML and warrant further investigation of the clinical application of SL-101 and other CD123-targeting strategies in AML. Clin Cancer Res; 23(13); 3385–95. ©2017 AACR.
In the Era of Bortezomib-Based Chemotherapy the Presence of Minimal Residual Disease Predicts Progression Free Survival after Autologous Hematopoietic Cell Transplant
Authors: Robert F Cornell, Jade E Jones, Claudio A. Mosse, Heidi Chen, Laura Dugger, Salil Goorha, Wichai Chinratanalab, Brian Engelhardt, Stacey A. Goodman, John P Greer, Shelton Lacy, Adetola A. Kassim, Kevin McDonagh, Bipin N. Savani, Salyka Sengsayadeth, Madan Jagasia
Journal: Blood (2015)
The Transcription Factors RUNX1/AML1 and RUNX3/AML2 Protect Bcr-Abl-Transformed B-Cells from Imatinib Induced Apoptosis.
Authors: Cornelius Miething, Rebekka Grundler, Claudia Mugler, Heike Pfeifer, Oliver Ottmann, Simone Barwisch, Michael Speicher, Christian Peschel, Justus Duyster
Journal: Blood (2005)
Novel Evidence That Hematopoietic Stem/Progenitor Cells (HSPCs) Are Mobilized During Hemolysis in an Erythrocyte Lysis-Derived, Sphingosine-1-Phosphate (S1P)-Dependent manner—the Crucial Involvement of Complement Cascade (CC) Activation and Attenuation of CXCR4 Retention Signaling
Authors: Kasia Mierzejewska, Magdalena Kucia, Janina Ratajczak, Mariusz Z Ratajczak
Journal: Blood (2012)
ZAP-70 Status May Not Predict Outcome after Non-Myeloablative Allogeneic Transplantation (NMT) in Patients with Chronic Lymphocytic Leukemia(CLL) Who Failed Conventional Chemotherapy.
Authors: Issa F. Khouri, Rima M. Saliba, Michael J. Keating, Joan Admirand, Susan O’Brien, Richard E. Champlin, Carlos Buenos-Ramos
Journal: Blood (2005)
Haploidentical, G-CSF Primed, Unmanipulated Bone Marrow Transplantation with Anti-CD25 Monoclonal Antibody As Part of the Gvhd Prophylaxis for Patients with High-Risk Acute Myeloid Leukemia
Authors: William Arcese, Stella Santarone, Alessandra Picardi, Raffaella Cerretti, Laura Cudillo, Gottardo De Angelis, Benedetta Mariotti, Gabriele Papalinetti, Paola Olioso, Patrizia Accorsi, Tiziana Bonfilini, Teresa Dentamaro, Luca Cupelli, Anna Chierichini, Antonella Ferrari, Andrea Mengarelli, Maria Cristina Tirindelli, Gaspare Adorno, Manuela Testi, Fabio Di Piazza, Paolo Di Bartolomeo
Journal: Blood (2015)
A Comparison of Lamivudine and Entecavir for the Prophylaxis of Hepatitis B Virus Reactivation in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation: A Single Institutional Experience
Authors: Jin Shang, Jing Sun, Zhiping Fan, Fen Huang, Yu Zhang, Qianli Jiang, Hongsheng Zhou, Qifa Liu
Journal: Blood (2015)
Efficacy of Cladribine, Cytarabine, G-CSF (Neupogen), Mitoxantrone (CLAG-M Regimen) Compared to Standard 3+7 (Anthracycline and Cytarabine) in Secondary Acute Myeloid Leukemia (sAML) After Azanucleosides Failure
Authors: Michael V. Jaglal, Vu H. Duong, Celeste M. Bello, Najla H Al Ali, Hugo F. Fernandez, Jeffrey E. Lancet, Alan F. List, Rami S. Komrokji
Journal: Blood (2011)
Murine CD103 + dendritic cells protect against steatosis progression towards steatohepatitis
Authors: Eva-Carina Heier, Anna Meier, Henrike Julich-Haertel, Sonja Djudjaj, Monica Rau, Thomas Tschernig, Andreas Geier, Peter Boor, Frank Lammert, Veronika Lukacs-Kornek
Journal: Journal of Hepatology (2017)
Prognostic Impact of Molecular Response Assessed By Next-Generation Sequencing in a Large Cohort of Multiple Myeloma Patients
Authors: Beatriz Sanchez-Vega, Rafael Alonso, Isabel Cuenca, Santiago Barrio, Yanira Ruiz-Heredia, Carlos Marin, Inmaculada Rapado, Cristina Jimenez, Xabier Aguirre, Rosa M. Ayala, Teresa Cedena, Bruno Paiva, Maria-Victoria Mateos, Laura Rosiñol, Joan Bladé, Jesus San Miguel, Ramon Garcia-Sanz, Juan José Lahuerta, Joaquín Martínez-López
Journal: Blood (2016)
The YAP Transcriptional Co-Activator Is Not Required for Mouse Hematopoiesis, at Steady State or After 5FU Treatment.
Authors: Wen-Chih Cheng, Osnat Bohana-Kashtan, Sebastien Morisot, Nailing Zhang, Qian Chen, Duojia Pan, Curt I. Civin
Journal: Blood (2010)
Characteristics of Diamond Blackfan Anemia Patients with Unknown Genetic Defect
Authors: Tamas Farkas, Joerg Meerpohl, Shinsuke Hirabayashi, Alyson MacInnes, Gunda Ruzaike, Paul Essers, Sandra Urbaniak, Jessica Moetter, Friedrich Kapp, Alexandra Fischer, Charlotte M Niemeyer, Marcin W Wlodarski
Journal: Blood (2012)
Lower Drug Exposure Is Related to Renal Function and Results in Inferior Survival: A Pharmacokinetic Study of High Dose Melphalan in Myeloma
Authors: Judith Trotman, Peter J. Shaw, Douglas E Joshua, Yiu-Lam Kwan, Campbell Tiley, Peter Presgrave, Ian H. Kerridge, Christa Nath
Journal: Blood (2012)
Reconstitution of Memory T -Cells after Allogeneic Stem Cell Transplantation in Patients with Post-Transplantation Cyclophosphamide As Tolerance Induction
Authors: Vera Vasilyeva, Elena N. Parovichnikova, Larisa A. Kuzmina, Mikhail Drokov, Ekaterina Mikhaltsova, Olga Koroleva, Daria Dubnyak, Irina Galtseva, Valeri G. Savchenko
Journal: Blood (2015)
Abnormal CD161 + immune cells and retinoic acid receptor–related orphan receptor γt–mediate enhanced IL-17F expression in the setting of genetic hypertension
Authors: Madhu V. Singh, Michael Z. Cicha, Santosh Kumar, David K. Meyerholz, Kaikobad Irani, Mark W. Chapleau, François M. Abboud
Journal: Journal of Allergy and Clinical Immunology (2017)
Selective Expansion of Human Regulatory (CD4+CD25+CD127LowFOXP3+) Cells to High Purity by Inhibiting Expansion of CD4+CD25+CD127HighFOXP3-Conventional T Cells with Rapamycin.
Authors: Jing-Zhou Hou, Elizabeth Zambricki, Robert Zeiser, Robert S. Negrin
Journal: Blood (2006)
Telomerase Activity Is High In Essential Thrombocythemia and Polycythemia Vera, but Not In Myelofibrosis – a Comprehensive Analysis on Telomerase Activity and Cytogenetics In Myeloproliferative Neoplasm and Myelodysplastic Syndromes
Authors: Miyoung Kim, Bora Oh, Tae Young Kim, Sang Mee Hwang, Dong Soon Lee
Journal: Blood (2010)
TCT-764 Bipolar Radiofrequency Renal Denervation with the Vessix Catheter in Patients with Resistant Hypertension: 2-year Results from the REDUCE-HTN Trial
Authors: Horst Sievert, Joachim Schofer, John A. Ormiston, Uta C. Hoppe, Ian T. Meredith, Darren Walters, Michel Azizi, Juan Diaz-Cartelle
Journal: Journal of the American College of Cardiology (2015)
Improved Outcome with Total Therapy 3 (TT3) In Comparison with Total Therapy 2 (TT2) Can Be Traced to GEP70-Defined High-Risk Disease with Trisomy of 1q21 and Modest but Not Marked Hyper-Activation of the Proteasome Gene PSMD4
Authors: John Shaughnessy, Pingping Qu, Erming Tian, Bijay Nair, Sarah Waheed, Yazan Alsayed, Frits van Rhee, John Crowley, Bart Barlogie
Journal: Blood (2010)
Comparison of Activated Partial Thromboplastin Time Ratios with Ecarin Clotting Time Ratios for Monitoring Direct Thrombin Inhibitor Therapy: In-Vitro Study and Case Study of Lepirudin Therapy.
Authors: Harry L. Messmore, Nancy J. Fabbrini, Ketty Badrinath, Richard Harriman, Omar Iqbal, Mary Lourdes Bird
Journal: Blood (2005)
ZAP70 Expression by Immunohistochemistry Correlates with IgVH Mutation Status in Chronic Lymphocytic Leukemia and Predicts Time to Progression, but Survival Is Decreased in p53-Positive CLL, Regardless of ZAP70 Expression.
Authors: Ellen J. Schlette, Constantine Tam, Joan Admirand, William Wierda, Susan O’Brien, Susan Lerner, Michael J. Keating
Journal: Blood (2007)