tbuckley/cabot-search huggingface dataset:
Endoscopic ultrasound-guided pancreatic duct drainage using antegrade stenting
Authors: Takeshi Ogura, Saori Onda, Tatsushi Sano, Kazuhiro Yamamoto, Daisuke Masuda, Akira Imoto, Kazuhide Higuchi
Journal: Endoscopy (2015)

Endoscopic ultrasound (EUS)-guided pancreatic duct access in patients with an inaccessible papilla or failed endoscopic retrograde cholangiopancreatography (ERCP) has been reported previously [1] [2]. This technique consists of the EUS-guided rendezvous technique, and EUS-guided pancreatic duct stenting via the stomach (pancreaticogastrostomy), or the duodenum (pancreaticoduodenostomy) [2]. However, the technical success rate of the EUS rendezvous technique is not very high [3], and it is not indicated in patients with altered anatomy, for example following a Roux-en-Y procedure. Stent occlusion is a risk of EUS-guided pancreaticoduodenostomy, and it may easily occur because of food impaction. Novel technical tips for EUS-guided pancreatic duct antegrade stenting are presented here ([Video 1]).
Streptomycin in Tuberculosis
Authors: R LAURIER
Journal: BMJ (1946)

TJHE efTicacy of streptomycin in the treat- menit of tuberculosis is 11o longer open to doubt.The ever-incr.easingreports in the literature attest to its value, l)ut these reports are still tinge(l with eaution and at times hiint at disappointment.There is, at one and the same time, enthusiasmii for the effect of the drug oIn tuberculous lesioins aiid doubt and disap- pointmeint l)ecause the etfect is not sufficiently marked, or is complicated by somiie of the perverse actions of the drug.That streptomyciin will aftect tuberculosis beneficially is iiow an accepted fact; that it will of itself cure
RO-16EXPERIENCE OF CRANIOSPINAL TOMOTHERAPY<sup>®</sup>IN CHILDREN AND YOUNG ADULTS: DELIVERABILITY AND ACUTE TOXICITY
Authors: Helen Woodman, Daniel Ford, Gurnaik Sangha, Claire Bode, Gareth Webster, Jason Cashmore, Martin English, Andrew Peet, Helen Benghiat
Journal: Neuro-Oncology (2016)
Multi-Virus-Specific T-Cell Therapy For Patients After Hematopoietic Stem Cell and Cord Blood Transplantation
Authors: Patrick Hanley, Ann Leen, Adrian P. Gee, Kathryn Leung, Caridad Martinez, Robert A. Krance, Hao Liu, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney, Catherine M. Bollard
Journal: Blood (2013)
Serum Mir-4254, Mir-19a and Mir-33b Are Potential Markers For Diagnosis and Prognostic Evaluation In Multiple Myeloma
Authors: Mu Hao, Meirong Zang, Qin Yu, Li Fei, Wenjuan Yang, Xiaoyan Feng, Fang Qi, Gang An, Changhong Li, Yan Xu, Fenghuang Zhan, Lugui Qiu
Journal: Blood (2013)
Cellular Derivation of Lung Tumors in Sensitive and Resistant Strains of Mice: Results at 28 and 56 Weeks After Urethan Treatment&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: L G Thaete, W T Gunning, G D Stoner, A M Malkinson
Journal: JNCI Journal of the National Cancer Institute (1987)

Urethan (CAS: 51-79-6)-induced pulmonary adenomas that arise from either alveolar type II pneumocytes of bronchiolar Clara cells have distinct histologic growth patterns and can thus be distinguished from each other. Strain differences were reported in the relative proportions of tumors derived from each cell type when these tumors were examined 14 weeks after urethan treatment. For determination as to whether these proportions changed at later stages of growth, tumors in A/J, SWR/J, RIIIS/J, BALB/cByJ, 129/J, and C57BL/6J mice were examined at 28 and 56 weeks after urethan treatment. Tumor multiplicity increased with time in all strains. Small tumors were predominantly type II cell derived in most strains, whereas medium and large tumors were derived mainly from Clara cells. This suggests that type II tumors are restricted in growth while Clara tumors may continue to grow. Medium and large Clara-derived tumors made up a larger proportion of the total tumor population at 28 and 56 weeks than at 14 weeks post urethan, even in A/J mice that typically display 85% type II cell-derived tumors at the earlier time. Several large Clara cell-derived tumors exhibited characteristics of cancer, whereas no type II cell-derived tumor was observed to do so. These results implicate the bronchiolar Clara cell as the predominant cell of origin of pulmonary adenocarcinomas in mice.
In-Vivo Labelling Studies in Patients with Chronic Lymphocytic Leukemia Studies Demonstrate the Existence of Apparently Distinct Subpopulations That Differ in Phenotype and Proliferative Capacity
Authors: Kirsty Cuthill, Yan Zhang, Andrea Buggins, Eve Coulter, Piers E. Patten, Derek Macallan, Stephen Devereux
Journal: Blood (2015)
Outbreak of Salmonella enteritis bongori 48:z35:- in Sicily
Authors: A Nastasi, C Mammina, L Salsa
Journal: Eurosurveillance (1999)

Salmonella bongori 48:z 35 :- was first isolated from a lizard in Chad in 1966 and was classified as a biochemically atypical strain of the subgenus I of Kauffmann. Successively, some additional strains with different antigenic formulas but similar bioche
Cardiovascular Events Associated With Use of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia
Authors: Torsten Dahlén, Gustaf Edgren, Mats Lambe, Martin Höglund, Magnus Björkholm, Fredrik Sandin, Anders Själander, Johan Richter, Ulla Olsson-Strömberg, Lotta Ohm, Magnus Bäck, Leif Stenke
Journal: Annals of Internal Medicine (2016)

Tyrosine kinase inhibitors (TKIs) have increased survival dramatically for patients with chronic myeloid leukemia (CML), but continuous administration of these drugs may elicit long-term toxicity.To investigate the incidence of vascular events in patients with CML treated with first- and second-generation TKIs.Retrospective cohort study using nationwide population-based registries.Sweden.All patients diagnosed with chronic-phase CML in Sweden from 2002 to 2012 and treated with a TKI, and 5 age- and sex-matched control individuals per patient.Relative risks, expressed as incidence rate ratios comparing patients with control individuals, were calculated. Events per 1000 person-years were assessed in interdrug comparisons.896 patients, 94.4% with documented TKI treatment, were followed for a median of 4.2 years. There were 54 arterial and 20 venous events in the CML cohort, corresponding to relative risks of 1.5 (95% CI, 1.1 to 2.1) and 2.0 (CI, 1.2 to 3.3), respectively. The event rate for myocardial infarction was higher in patients treated with nilotinib or dasatinib (29 and 19 per 1000 person-years, respectively) than in those receiving imatinib (8 per 1000 person-years), although data are limited and the CIs were wide and overlapped. Among 31 patients treated with a TKI who had myocardial infarction, 26 (84%) had at least 1 major cardiac risk factor diagnosed before the event occurred.Patients may have been exposed to multiple TKIs. Data on second- and third-generation TKIs were limited.An increased risk for arterial and venous vascular events was seen in patients with CML treated with a TKI. Further study is needed to determine whether the risk for myocardial infarction increases with second-generation drugs.No external funding.
EPT-03PHARMACOKINETICS OF HIGH-DOSE METHOTREXATE IN INFANTS AGED LESS THAN 12 MONTHS TREATED FOR BRAIN TUMORS
Authors: Maurizio Lucchesi, Milena Guidi, Carla Fonte, Silvia Farina, Claudio Favre, Lorenzo Genitori, Iacopo Sardi
Journal: Neuro-Oncology (2016)
Adjuvant chemoendocrine therapy in breast cancer.
Authors: G Bonadonna, P Valagussa
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.4.451 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3514802 Adjuvant chemoendocrine therapy in breast cancer. G BonadonnaxG BonadonnaSearch for articles by this author , P ValagussaxP ValagussaSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.4.451 First Page PDF © 1986 by American Society of Clinical Oncology
Gene expression differentiates liver metastases from isolated peritoneal metastases in colorectal cancer
Authors: W. P. Ceelen, N. Van Damme, P. Van Hummelen, P. Pattyn, B. de Hemptinne, M. Peeters
Journal: Journal of Clinical Oncology (2008)

15022 Background: Metastatic spread is the leading cause of colorectal cancer deaths. In a minority of patients, peritoneal carcinomatosis (PC) develops in the absence of distant metastasis. It is unknown, whether differences in gene expression underlie this specific behaviour of PC. The aim of the current study was to compare global gene expression between liver metastases (LM) and isolated PC resection specimens. Methods: Gene expression profiles were determined from 10 LM and 7 isolated PC patients. From each patient RNA was extracted from fresh frozen tumour and adjacent normal tissue, taken at resection. Microarray analysis was conducted on Affymetrix U133 2.0 full genome arrays. Statistical comparison was performed by a linear model t-test with Benjamini-Hochberg correction for multiple testing using GeneMaths XT (Applied Maths). Results: Statistical analysis between the 2 normal tissues and between the 2 tumour tissues yielded 16,824 and 1,479 differentially expressed probes, respectively. Principal Component Analysis and cluster analysis showed that normal tissues were vastly different while tumour tissues were more comparable. After correction for this apparent normal tissue signature the true number of genes differentially expressed between the 2 types of secondary tumours was 179. The majority of those genes are involved in immune response, cellular differentiation, epithelial to mesenchymal transition (EMT), and cell growth. The most significant gene pathways were the IL6 and TGF-β signalling, Wnt and Notch pathways that were generally higher expressed in PC specimens. Conclusions: Gene expression profiles differentiate LM from isolated PC in colorectal cancer patients. At present, it is unclear whether the observed difference in gene expression is responsible for tissue selection during invasion or represents a re-differentiation signature induced by the target organ. No significant financial relationships to disclose.
NS-21MULTI-CATHETER INTERMITTENT CONVECTION-ENHANCED DELIVERY OF CARBOPLATIN AS A TREATMENT FOR DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG): PRE-CLINICAL RATIONALE AND EARLY CLINICAL EXPERIENCE
Authors: William G.B. Singleton, Neil U. Barua, James Morgan, Alison S. Bienemann, Clare L. Killick-Cole, Daniel J. Asby, Richard J. Edwards, Stephen P. Lowis, Steven S. Gill
Journal: Neuro-Oncology (2016)
Cardiac arrhythmias during laparoscopy.
Authors: A Damiano, J M Herrerias, F Sarnago, J A Jiménez, M Garrido
Journal: BMJ (1972)

large enough to be able to guarantee prompt return of work to the firms supplying the work.In a small unit of this type this would be quite inconsistent with the requirement to provide as great a variety of work as possible.So far as local authority hostels are concerned the suggestion is that these should be quite small and should not be concentrated in one place.To staff scattered small units would be very much more ex- pensive in staff than in existing units.Has the Department really faced the financial implications of this? Recruitment of StaffThere are also problems of staff recruitment and training.Would the smaller general hos- pital units receive approval as training centres from the Royal College of Psychia- trists or the General Nursing Council?There is the further problem of career prospects in psychiatric nursing.Many psychiatric nurses fear that general nurses understand psychiatric nursing so little that the general hospital nursing hierarchy would not allow them to do their job.For instance, they ask would any general hospital matron understand that it is part of mental nursing to organize games or even to play billiards with patients?With the implementation of the Salmon structure it is unlikely that many psychiatric units would be large enough to rank an area nursing officer above Grade 8.This must inevitably deter nurses of the best calibre from entering psychiatry.-Weare, etc.,
Temozolomide for 1P19Q Co-Deleted and Partially Deleted Gliomas
Authors: M.G. McNamara, H. Jiang, M.J. Lim Fat, S. Sahebjam, T.R. Kiehl, J. Karamchandani, C. Coire, C. Chung, B. Millar, N. Laperriere, W. Mason
Journal: Annals of Oncology (2014)
Slow response by FDA to food scares leaves public at risk, watchdog says
Authors: Michael McCarthy
Journal: BMJ (2016)

US consumers can remain at risk of illness or death for weeks after the US Food and Drug Administration (FDA) is aware that potentially hazardous food is in the supply chain because the agency lacks policies and procedures to ensure prompt product recalls, the FDA’s Office of the Inspector General (OIG) said in a report released 8 June.1

In the report, the agency’s Inspector General, Daniel R Levinson said, “We found that the FDA did not have an efficient and effective food recall initiation process that helps ensure the safety of the …
Gene Expression Profiling in Porcine Fetal Thymus
Authors: Yanjiong Chen, Shengbin Li, Lin Ye, Jianing Geng, Yajun Deng, Songnian Hu
Journal: Genomics Proteomics & Bioinformatics (2003)

To obtain an initial overview of gene diversity and expression pattern in porcine thymus, 11,712 ESTs (Expressed Sequence Tags) from 100-day-old porcine thymus (FTY) were sequenced and 7,071 cleaned ESTs were used for gene expression analysis. Clustered by the PHRAP program, 959 contigs and 3,074 singlets were obtained. Blast search showed that 806 contigs and 1,669 singlets (totally 5,442 ESTs) had homologues in GenBank and 1,629 ESTs were novel. According to the Gene Ontology classification, 36.99% ESTs were cataloged into the gene expression group, indicating that although the functional gene (18.78% in defense group) of thymus is expressed in a certain degree, the 100-day-old porcine thymus still exists in a developmental stage. Comparative analysis showed that the gene expression pattern of the 100-day-old porcine thymus is similar to that of the human infant thymus.
Abstract 4210: Evaluation of Coronary Stenoses and their Functional Significance in Patients with Known and Suspected Coronary Artery Disease using MRI and CTA
Authors: Jacob Van Werkhoven, Joanne Schuijf, J Wouter Jukema, Joop Schreur, Mark Heijenbrok, Gabija Pundziute, Martin Schalij, Ernst Van der Wall, Jeroen Bax
Journal: Circulation (2008)

Objectives: Non-invasive computed tomography coronary angiography (CTA) is an accurate anatomic imaging technique, but cannot assess the hemodynamic severity of the detected atherosclerotic lesions. In patients with abnormal CTA, optimal treatment strategy may therefore remain uncertain. The purpose of the current study was to compare anatomic observations with CTA to functional assessment with MRI in patients with known and suspected CAD. Methods: In this prospective study, 55 patients (62% male, average age 57±9 years, pre-test likelihood low to intermediate 62%) underwent 64-slice CTA and 1.5 Tesla MRI within 40 days. The presence of CAD (normal &lt;30% stenosis, non-significant 30%–50% stenosis, and significant &gt;50% stenosis) was determined on CTA and first pass perfusion during adenosine stress was assessed on MRI. Results: CTA was normal in 15 (27%), non-significant in 24 (44%) and significant in 16 (29%) patients. MRI revealed a perfusion defect in 21 (38%) patients, and was normal in 34 (62%). Table 1 shows the CTA results for patients with normal and abnormal perfusion on MRI. CTA was abnormal in almost all patients with an abnormal perfusion. However, a normal perfusion MRI study was associated with abnormal CTA in a large proportion of patients, as non-significant and significant CAD was noted in 15 (44%) and 5 (15%) patients respectively. Conclusion: Although abnormal perfusion on MRI correlated well with abnormal CTA, underlying CAD is present in the majority of patients with a normal MRI perfusion study. The combination of both techniques may allow more refined characterization of CAD. Table 1
Clinical Practice Guidelines for Colorectal Cancer Screening
Authors: David F. Ransohoff, Harold C. Sox
Journal: JAMA (2016)

US Preventive Services Task Force; Kirsten Bibbins-Domingo, PhD, MD, MAS; David C. Grossman, MD, MPH; Susan J. Curry, PhD; Karina W. Davidson, PhD, MASc; John W. Epling Jr, MD, MSEd; Francisco A. R. García, MD, MPH; Matthew W. Gillman, MD, SM; Diane M. Harper, MD, MPH, MS; Alex R. Kemper, MD, MPH, MS; Alex H. Krist, MD, MPH; Ann E. Kurth, PhD, RN, MSN, MPH; C. Seth Landefeld, MD; Carol M. Mangione, MD, MSPH; Douglas K. Owens, MD, MS; William R. Phillips, MD, MPH; Maureen G. Phipps, MD, MPH; Michael P. Pignone, MD, MPH; Albert L. Siu, MD, MPH
Validity of a diagnosis of lifetime major depression obtained by personal interview versus family history
Authors: K S Kendler, M A Roy
Journal: American Journal of Psychiatry (1995)

Diagnoses obtained by family history agree only modestly with those obtained through personal interview. If personal interview diagnoses are the "gold standard," these findings suggest that family history diagnoses have low validity. Here the authors take another perspective--to evaluate family history versus personal interview diagnoses of lifetime major depression by three independent validators.In a large sample of female-female twin pairs and their parents (903 families) ascertained from a population-based twin register, all subjects were personally interviewed by using a modified Structured Clinical Interview for DMS-III-R. Family history diagnoses based on the Family History Research Diagnostic Criteria were obtained by questioning each participant about his or her relatives. By means of multiple regression, the powers of the personal interview and family history methods were compared to predict 1) future episodes of major depression in the twins, 2) neuroticism, and 3) familial aggregation of major depression.Agreement between diagnoses obtained by personal interview and family history was modest. After the presence or absence of a personal interview diagnosis of major depression was controlled for, a family history diagnosis of major depression significantly predicted future episodes of major depression, neuroticism (in five of six analyses), and familial aggregation of major depression (in four of six analyses).Although agreeing relatively poorly, diagnoses of lifetime major depression obtained by personal interview and family history both contained useful information about future episodes, personality, and familial liability to illness. A multimethod approach to assessment of psychiatric illness may maximize the validity of psychiatric diagnoses.
Case 17-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Edward A. Gaensler, Robert T. McCluskey
Journal: New England Journal of Medicine (1976)

Presentation of CaseA 19-year-old woman was admitted to the hospital because of hemoptysis.She was well until one month earlier, when she began to experience morning stiffness in the fingers and knees, accompanied by intermittent swelling of the wrists, fingers, knees and feet and fatigue. One week before admission she coughed up a small amount of blood while performing calisthenics; a nonproductive cough persisted. On the day of entry she complained of a dull headache; her family thought that she appeared dyspneic and noticed that her cough was more prominent and her sputum tinged with blood. She ate little . . .
Studies on the Enzymatic Degradation of Nucleic Acids
Authors: Charles E. Garter, Jesse P. Greenstein
Journal: JNCI Journal of the National Cancer Institute (1946)

Journal Article Studies on the Enzymatic Degradation of Nucleic Acids Get access Charles E. Garter, Charles E. Garter assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 1, August 1946, Pages 29–45, https://doi.org/10.1093/jnci/7.1.29 Published: 01 August 1946
Traumatic bile leak in war-injured Syrians: five patients treated by ERCP
Authors: Iyad Khamaysi, Alain Suissa, Kamal Yassin, Ian Gralnek
Journal: Endoscopy (2015)

About 20 months ago, an open letter was published in The Lancet calling for patients from the Syrian civil war to be treated [1]. Specifically, the letter said, "It is our professional, ethical, and moral duty to provide treatment and care to anyone in need".
The Defensins Consist of Two Independent, Convergent Protein Superfamilies
Authors: Thomas M. A. Shafee, Fung T. Lay, Mark D. Hulett, Marilyn A. Anderson
Journal: Molecular Biology and Evolution (2016)

The defensin and defensin-like proteins are an extensive group of small, cationic, disulfide-rich proteins found in animals, plants, and fungi and mostly perform roles in host defense. The term defensin was originally used for small mammalian proteins found in neutrophils and was subsequently applied to insect proteins and plant γ-thionins based on their perceived sequence and structural similarity. Defensins are often described as ancient innate immunity molecules and classified as a single superfamily and both sequence alignments and phylogenies have been constructed. Here, we present evidence that the defensins have not all evolved from a single ancestor. Instead, they consist of two analogous superfamilies, and extensive convergent evolution is the source of their similarities. Evidence of common origin necessarily gets weaker for distantly related genes, as is the case for defensins, which are both divergent and small. We show that similarities that have been used as evidence for common origin are all expected by chance in short, constrained, disulfide-rich proteins. Differences in tertiary structure, secondary structure order, and disulfide bond connectivity indicate convergence as the likely source of the similarity. We refer to the two evolutionarily independent groups as the cis-defensins and trans-defensins based on the orientation of the most conserved pair of disulfides.
LG-41NATURAL HISTORY OF PAEDIATRIC TECTAL PLATE GLIOMAS: THE EXPERIENCE OF A DECADE
Authors: Nida Kalyal, Claire Cairns, Florence Hogg, Harutomo Hasegawa, Sanj Bassi, Chris Chandler, Henry Mandeville, Stergios Zacharoulis, Bassel Zebian
Journal: Neuro-Oncology (2016)
The decline of state mental hospitals as training sites for psychiatric residents
Authors: J W Thompson, A Checker, M J Witkin, M M Silverman, H H Goldman
Journal: American Journal of Psychiatry (1983)

There has been national concern regarding the decreasing number of U.S. medical students entering psychiatric residency training programs in the 1970s at the same time that the Graduate Medical Education National Advisory Committee (GMENAC) report designated psychiatry as one of only three medical specialties with a manpower shortage. The authors document the decline in psychiatric residents in state mental hospitals from 1975 to 1980 and analyze five possible explanations for this absolute and relative decrease. They discuss approaches to altering the situation as well as the emerging role of the state mental hospital in the future training of psychiatric residents.