tbuckley/cabot-search huggingface dataset:
PET/CT Response Criteria (European Organization for Research and Treatment of Cancer) Predict Survival Better Than Response Evaluation Criteria in Solid Tumors in Locally Advanced Cervical Cancer Treated With Chemoradiation
Authors: Jung Won Yoon, Sunghoon Kim, Sang Wun Kim, Young Tae Kim, Won Jun Kang, Eun Ji Nam
Journal: Clinical Nuclear Medicine (2016)

To investigate whether the ratio of SUVs measured with F-FDG PET/CT between pretreatment and posttreatment has prognostic value in patients with locally advanced cervical cancer treated with primary chemoradiation therapy.Cases of locally advanced cervical cancer (International Federation of Gynecology and Obstetrics stages IB1 to IVA) treated with a nonsurgical curative modality (172 cases including chemoradiation or radiation therapy) were reviewed. F-FDG PET/CT parameters, including SUVmax and SUVmean, were evaluated by F-FDG PET/CT performed prior to treatment and 6 weeks after the end of treatment. Metabolic response was evaluated according to the European Organization for Research and Treatment of Cancer guidelines and was compared with radiologic response measured according to the Response Evaluation Criteria In Solid Tumours (RECIST).In total, 142 patients receiving chemoradiation showed radiologic responses (median 56% decrease in maximal diameter), whereas 160 and 146 patients showed metabolic responses measured with SUVmax and SUVmean, respectively (73% decrease in SUVmax; 48% decrease in SUVmean). Radiologic response and metabolic response were significantly correlated for SUVmax and SUVmean (P = 0.0009; P = 0.0457, respectively). Kaplan-Meier analysis revealed significant differences in overall survival and progression-free survival between the responder and nonresponder groups, based on the European Organization for Research and Treatment of Cancer criteria (both P < 0.001), whereas no significant difference was found when using RECIST criteria (P = 0.058, P = 0.088, respectively).F-FDG PET/CT parameters are good prognostic markers for the response of cervical cancer patients to concurrent chemoradiation therapy, as compared with the RECIST criteria.
Long-term outcome of treatment-resistant depression in older adults
Authors: A Stoudemire, C D Hill, R Morris, B J Lewison
Journal: American Journal of Psychiatry (1993)

Seventeen elderly patients with treatment-resistant depression were reassessed 15 months and 4 years after treatment with an antidepressant agent or ECT. At 15 months 47% (seven of 15) were clinically improved, and at the 4-year follow-up 71% (10 of 14) were improved. These results indicate that treatment-resistant depression may improve over time because of either the natural course of the illness or persistent treatment efforts.
Clinical Science and Francis Bacon
Authors: J. R. E.
Journal: Annals of Internal Medicine (1964)

Editorials1 December 1964Clinical Science and Francis BaconJ. R. E.J. R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-61-6-1199 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBut the best demonstration by far is experience, if it go not beyond the actual experiment. For if it be transferred to other cases which are deemed similar, unless such transfer be made by a just and orderly process, it is a fallacious thing.—FRANCIS BACON, The New Organon, lxx, 1620.In this issue of the ANNALSappears the concluding paper by Feinstein onScientific Methodology in Clinical Medicine. These four papers present the thesis that the clinician at the bedside has just as much need of scientific method as does the investigator working in the laboratory. Since every act of...References1. BACON F: The Great Instauration, 1620. Google Scholar2. EISELEY L: a. Francis Bacon as educator. Science 1197: 133, (21 April) 1961; b. Francis Bacon and the Modern Dilemma, University of Nebraska Press, Lincoln, 1962. Google Scholar3. BOWEN CD: Francis Bacon. The Temper of a Man, Little, Brown, and Co., Boston, 1963. Google Scholar4. Undoubtedly this issue was settled this past summer in Edinburgh during the Shakespeare festival—a group of highly partisan students publicly burned the books of Francis Bacon.—Ed. Google Scholar5. BACON F: The Advancement of Learning, bk. ii, 1605. Google Scholar6. BACON F: Essays, 1625: a. xxx, of Regiment of Health, b. xxvii, Of Friendship. Google Scholar7. MEDAWAR PB: Is the scientific paper fraudulent? The Listener, Sept. 12 1963, republished in Saturday Rev., 42, Aug. 1, 1964. Google Scholar8. PLATT JR: Strong inference. Science 146: 347, (16 October) 1964. CrossrefMedlineGoogle Scholar9. BACON F: The New Organon, ciii, 1620. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1964Volume 61, Issue 6Page: 1199-1202KeywordsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 December 1964 PDF downloadLoading ...
Sleep EEG and DST findings in anergic bipolar depression
Authors: M E Thase, J M Himmelhoch, A G Mallinger, D B Jarrett, D J Kupfer
Journal: American Journal of Psychiatry (1989)

The authors report sleep EEG and dexamethasone suppression test (DST) findings for a homogeneous sample of anergic bipolar depressed outpatients (bipolar I, N = 7; bipolar II, N = 19) characterized by motor retardation, volitional inhibition, hypersomnia, or weight gain and sleep EEG findings for 26 age- and sex-matched normal control subjects. Sleep architecture was abnormal in bipolar depression, particularly with respect to little stage 1 sleep. The biological profile of an anergic episode of bipolar depression did not include a shorter than normal mean REM latency, poor sleep continuity, or abnormally low amounts of stages 3 and 4 sleep, and only three (13%) of 23 patients manifested cortisol nonsuppression.
Why is UEFA carrying out injury studies?
Authors: Michel D'Hooghe
Journal: British Journal of Sports Medicine (2016)

Football is the most popular sport in the world, with more than 270 million people playing the game.1 However, injuries in football remain a major issue, especially given how much is at stake in the game.2 ,3 Awareness of injuries has increased over the years, and both UEFA and FIFA are concerned about the risk of injury and injury patterns in football, especially when it comes to the increasing numbers of hamstring injuries.4 ,5 Both governing bodies have highlighted the importance of professional medical support and stressed the need for greater football-specific medical expertise. They have therefore initiated and funded research aimed at safeguarding players' health and keeping them on the pitch.6

This issue of the BJSM contains six articles …
Intestinal Tissue Blood Flow in Shock Due to Endotoxin
Authors: RALPH R. RAYNER, LLOYD D. MacLEAN, EUGENE GRIM, Louis M. Levy
Journal: Circulation Research (1960)

An attempt has been made to measure the capillary blood flows through the individual tissues of the ileum of normal dogs and those which were in endotoxin shock. The technic used was based upon the assumption that the uptake of D 2 O by the tissues was limited by the capillary flow. In loops from endotoxin shock dogs which were perfused at normal blood pressure (135 mm. Hg), the tissue perfusion ratios calculated on this assumption were reduced to about one-half of the control value in the mucosa and to about three-fourths in the submucosa and muscularis, despite the fact that total blood flow was unchanged. When the loops from shock dogs were perfused at the dog's pressure (70 mm. Hg), there was a further decrease of about 50 per cent in both the total blood flow and the tissue perfusion ratios. It is concluded that this reduction in tissue capillary flow, especially in the mucosa, may be the basis of the pathological changes in the intestine in endotoxin shock.
AB0394 The Body Mass Index Predicts the Serum and Synovial Cartilage Oligomeric Matrix Protein Level in Early and Established Rheumatoid Arthritis Patients
Authors: T.A. Gheita, A. El Defrawy, H. Raslan, M. El Ansary, A. El Awar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Cartilage oligomeric matrix protein (COMP) is a major non-collagenous component of cartilage that accounts for approximately 1% of the wet weight of articular tissue. <h3>Objectives</h3> To assess the COMP levels in serum and synovial fluid in early and established rheumatoid arthritis (RA) patients and correlate the levels with clinical, laboratory and radiological characteristics. <h3>Methods</h3> Twenty-four female RA patients were included. Full history taking, thorough clinical examination and laboratory investigations were performed and the body mass index (BMI) recorded. Radiological damage was assessed according to the modified Larsen score. Disease activity score-28 (DAS-28) was calculated. Thirty age and sex matched subjects constituted the control. The serum COMP level was determined by ELISA. <h3>Results</h3> The patients9 age was 44.04±10.5 years. Twelve had early RA and another 12 had established disease with joint destruction; 5 of each group had knee effusion. The serum COMP was significantly higher in the patients (19.54±5.47μg/ml) compared with the control (5.93±1.95μg/ml) (p&lt;0.001). It was significantly higher in the patients with established disease (23.9±3.1μg/ml) compared to early ones (15.1±3.2μg/ml) (p&lt;0.001). Synovial COMPA was also significantly increased in established cases compared to early (31.2±9.8μg/ml vs 51.6±10.4μg/ml, p=0.013). The serum and synovial COMP significantly correlated with the age, disease duration, BMI, DAS28 and modified Larsen score. On performing the regression analysis in the RA patients, only the BMI could predict the serum level of COMP (p=0.02). <h3>Conclusions</h3> In conclusion, COMP is a promising biomarker of disease activity in RA making it a potential therapeutic target. The obvious correlation with the body mass index throws light on the importance of weight control not only in OA but in RA. <h3>Disclosure of Interest</h3> None declared
PTU-172 The “sunk” colostomy: a novel corrective approach to achieve satisfactory function
Authors: K Siddique, G Prudhomme, K Khan
Journal: Gut (2015)

<h3>Introduction</h3> Gastrointestinal stomas are a frequently performed surgical procedure with associated early or late complications. Some of these complications demand advanced technical skills and expertise to manage. We present here a challenging case of sunken colostomy affecting patient’s quality of life and a novel approach to achieve a satisfactory functional outcome. <h3>Method</h3> <b>Case report</b>: A 63 year old male underwent defunctioning loop colostomy for locally advanced rectal cancer with liver metastasis. Three months later he presented with difficulties managing his stoma. He had developed a horizontal skin crease along the stoma leading to obliteration of stomal opening causing ineffective stoma bag adhesion, resulting in painful parastomal ulcers. The patient was reluctant to consider stoma resiting owing to his job which involved leaning against machinery on his right side. Urgent surgical intervention was required so that his neo-adjuvant therapy would not be delayed. <h3>Results</h3> Our novel approach involved the excision of large supero-lateral elliptical fold of anterior abdominal wall down to the fascia with resultant opening up of colostomy. Care was taken to ensure precise excision resulting in flattening of abdominal wall as well as avoidance of future stoma appliance impingement. <h3>Conclusion</h3> <b>Discussion</b>: This technique draws parallels to the principles of blepharoplasty of upper eyelids, where droopy eyelid tissue is recontoured to unblock the visual axis. This approach also carried the advantage of operating away from the stoma site thereby preventing potential complication of stomal injury and wound infections. <h3>Conclusion</h3> Early successful result has established the feasibility of this novel approach, which has not been reported before. <h3>Disclosure of interest</h3> None Declared.
Therapy groups for women
Authors: C S Wolman
Journal: American Journal of Psychiatry (1976)

The author describes her experiences with two all-female psychotherapy groups, comparing these groups with both mixed-sex and consciousness-raising groups. Problems included a tendency of group members to drop out when dependency on the group became too intense and a lack of referrals to replace these dropouts, with resulting decreases in group size. The special strengths of such groups include the opportunity to concentrate on issues relevant to women, the possibility for development of a support system, the lack of sex-role divisions of labor, and the increased respect of members for other women and for themselves.
Boarding schools: effects on the mental health of Eskimo adolescents
Authors: J Kleinfeld, J Bloom
Journal: American Journal of Psychiatry (1977)

Whether boarding schools undermine the mental health of Eskimo and Indian children has been a bitterly debated issue. The authors examined the effects of four representative boarding schools on 132 Alaskan Eskimo adolescents during their freshman and sophomore years. Forty-nine percent of the freshmen developed school-related social and emotional disturbances; 25% of these problems were judged serious. High levels of emotional disturbance were also found during the students' sophomore year. Although simple environmental changes may temporarily reduce the rate of disturbance among students, the long-term effects of boarding schools may still be deleterious.
Relation of Chemical Structure to Development of Tumor Damage and Body Tremors in a Series of Phenazines and Related Compounds
Authors: Margaret G. Kelly, Norman H. Smith, Joseph Leiter
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Relation of Chemical Structure to Development of Tumor Damage and Body Tremors in a Series of Phenazines and Related Compounds Get access Margaret G. Kelly, Margaret G. Kelly Search for other works by this author on: Oxford Academic PubMed Google Scholar Norman H. Smith, Norman H. Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph Leiter Joseph Leiter Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 6, June 1958, Pages 1113–1122, https://doi.org/10.1093/jnci/20.6.1113 Published: 01 June 1958 Article history Received: 22 November 1957 Published: 01 June 1958
PTU-057 Inflammatory bowel disease and the risk of thromboembolic disease
Authors: A Kumar, BR Disney, L Wood, J Slater, S de Silva
Journal: Gut (2015)

<h3>Introduction</h3> Patients with inflammatory bowel disease (IBD) are thought to be associated with an increased risk of developing venous thromboembolic (VTE) disease and arterial thrombi (AT). There is conflicting data on the prevalence of VTE disease and AT in IBD, varying between 1.2% and 6.7% in clinical studies, which rises to 39% in postmortem studies. Our aims were to evaluate the rate and risk factors of VTE and AT in a large cohort of IBD patients. <h3>Method</h3> We performed a retrospective review between the years 1984 to 2014 of all patients with IBD. These patients were identified from the IBD database and cross-referenced with the online electronic reporting system, patient notes and clinic letters. <h3>Results</h3> There were a total of 1678 patients with IBD, with 47 found to have VTE and AT, giving a prevalence rate of 2.8%. Of these 47 patients, 8 (17%) patients had recurrent disease with 6 (12.8%) patients having 2 incidents and 2 (4.2%) patients having 3 incidents of VTE disease. The median age was 60.2 years old with a greater risk for males than females (55% vs. 45%) and with ulcerative colitis than Crohn’s disease (2.8% vs. 0.87%). 36 (2.1%) patients were diagnosed with deep venous thrombosis (DVT) and 20 (1.2%) with pulmonary embolism (PE). The remaining four had portal vein thrombosis, common femoral artery occlusion, femoral artery embolus and superficial femoral artery occlusion. Three patients were diagnosed with both DVT and PE in the same admission. The average duration from time of IBD diagnosis to VTE and AT confirmation was 7.4 years. 5 patients were identified with VTE prior to their IBD diagnosis. At the time of their diagnosis, 3 (5.3%) patients were treated for malignancy in the previous six months and 4 (7%) had undergone surgery in the previous four weeks. 32 (56%) patients were being treated with 5-aminosalicylic acid (5ASA) drugs, 17 (30%) with azathioprine, 12 (21%) with oral steroids, 4 (7%) with intravenous (IV) steroids, 2 (4%) had infliximab and 1 (2%) had adalimumab. Blood tests at time of diagnosis showed a median CRP of 46 and platelet count of 345. The mortality rate was 10.6%, of which one death was directly related to their VTE. 10.5% underwent surgery, 63% were anticoagulated and 1.8% underwent failed tissue plasminogen activator (TPA) therapy. 3.5% were left with a disability secondary to their VTE disease. <h3>Conclusion</h3> Thromboembolic disease is an increasingly prevalent and preventable complication of IBD. Positive risk factors identified in our cohort were patients that were male, increasing age and diagnosis of ulcerative colitis. Considering almost one third of those diagnosed were receiving oral or IV steroid therapy and had an average raised CRP, this supports the view that a disease flare is an ongoing risk factor for developing VTE and AT. <h3>Disclosure of interest</h3> None Declared.
PCI at Hospitals with or without On-Site Cardiac Surgery
Authors: Haruo Tomoda
Journal: New England Journal of Medicine (2013)

To the Editor: Jacobs et al. (April 18 issue)1 report the findings of the Randomized Trial to Compare Percutaneous Coronary Intervention between Massachusetts Hospitals with Cardiac Surgery On-Site and Community Hospitals without Cardiac Surgery On-Site (MASS COMM). They found that nonemergency percutaneous coronary intervention (PCI) procedures performed at hospitals without on-site surgery were noninferior to procedures performed at hospitals with on-site surgery. Because of the nonurgent nature of elective PCI at hospitals without on-site surgery, PCI programs must meet the rigorous standards described in this study. The most crucial factor is the experienced operator who provides outcomes that are equivalent or superior to national benchmarks.2 Medicare administrative data have shown higher mortality in low-volume hospitals without on-site surgery.3 In the study by Jacobs et al. and other studies showing favorable outcomes, all operators in hospitals without on-site surgery also performed PCI at partner hospitals with on-site surgery.1,4 In the National Cardiovascular Data Registry, 81% of operators in hospitals without on-site surgery also performed PCI at hospitals with onsite surgery.5 Operators in hospitals without on-site surgery who also practice or have practiced at hospitals with on-site surgery provide the same quality of care with respect to pharmacotherapy, PCI procedures, and working relationships with surgeons as operators in hospitals with on-site surgery. A rarely acknowledged component of successful PCI programs in hospitals without on-site surgery appears to be operators who practice at both types of hospitals.1,4,5
IgM Antibody to a Tumor-Associated Antigen (AG-4) Induced by Herpes Simplex Virus Type 2: Its Use in Location of the Antigen in Infected Cells 2
Authors: L. Aurelian, M. F. Smith, D. J. Cornish
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article IgM Antibody to a Tumor-Associated Antigen (AG-4) Induced by Herpes Simplex Virus Type 2: Its Use in Location of the Antigen in Infected Cells Get access L. Aurelian, L. Aurelian Search for other works by this author on: Oxford Academic PubMed Google Scholar M. F. Smith, M. F. Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar D. J. Cornish D. J. Cornish 3Departments of Laboratory Animal Medicine and Mi.crobiology. The Johns Hopkins University School of Medicine, Baltimore, Md. 21205. 4We thank Mrs. R. Miante and Miss M. Albuerne for their technical assistance. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 3, March 1976, Pages 471–477, https://doi.org/10.1093/jnci/56.3.471 Published: 01 March 1976 Article history Received: 15 April 1975 Revision received: 24 July 1975 Accepted: 03 October 1975 Published: 01 March 1976
Abdominal adiposity, general obesity, and subclinical systolic dysfunction in the elderly: A population‐based cohort study
Authors: Cesare Russo, Fusako Sera, Zhezhen Jin, Vittorio Palmieri, Shunichi Homma, Tatjana Rundek, Mitchell S.V. Elkind, Ralph L. Sacco, Marco R. Di Tullio
Journal: European Journal of Heart Failure (2016)
Immunohistochemical characterization of a 183 KD myeloid-specific-DNA- binding protein in B5 fixed, paraffin-embedded tissues, and bone marrow aspirates by monoclonal antibody BM-1
Authors: AL Epstein, M Samoszuk, E Stathopoulos, GS Naeve, CV Clevenger, S Weil, RJ Marder
Journal: Blood (1987)
Female doctors in US earn much less than male doctors, study finds
Authors: Abi Rimmer
Journal: BMJ (2016)

Female doctors in the United States earn significantly less than their male counterparts, even after adjustment for specialty, experience, and hours worked, research published in The BMJ has found.1 The researchers also found that white male doctors earned more than their black male colleagues.

The situation is similar to that in the United Kingdom, where female doctors earn 40% less than …
The family and schizophrenia
Authors: D Reiss
Journal: American Journal of Psychiatry (1976)

The author discusses the role of the family in the etiology of schizophrenia and suggests how this research might be integrated with our growing knowledge of the biology of schizophrenia. Abnormalities of family interaction-particularly communication deviances-are frequently associated with schizophrenia and may play a causal, rather than epiphenomenal, role in its pathogenesis. Communication processes in family life affect the child's development of attentional and perceptual capacities, which also have strong biologic roots. The author suggests that the study of normal and abnormal perceptual development might be a meeting ground for researchers in the areas of the biological and familial theories of schizophrenia.