tbuckley/cabot-search huggingface dataset:
The Structure, Expression, and Function Prediction of <i>DAZAP2</i>, A Down-Regulated Gene in Multiple Myeloma
Authors: Yiwu Shi, Saiqun Luo, Jianbin Peng, Chenghan Huang, Daren Tan, Weixin Hu
Journal: Genomics Proteomics & Bioinformatics (2004)

In our previous studies, DAZAP2 gene expression was down-regulated in untreated patients of multiple myeloma (MM). For better studying the structure and function of DAZAP2, a full-length cDNA was isolated from mononuclear cells of a normal human bone marrow, sequenced and deposited to Genbank (AY430097). This sequence has an identical ORF (open reading frame) as the NM_014764 from human testis and the D31767 from human cell line KG-1. Phylogenetic analysis and structure prediction reveal that DAZAP2 homologues are highly conserved throughout evolution and share a polyproline region and several potential SH2/SH3 binding sites. DAZAP2 occurs as a single-copy gene with a four-exon organization. We further noticed that the functional DAZAP2 gene is located on Chromosome 12 and its pseudogene gene is on Chromosome 2 with electronic location of human chromosome in Genbank, though no genetic abnormalities of MM have been reported on Chromosome 12. The ORF of human DAZAP2 encodes a 17-kDa protein, which is highly similar to mouse Prtb. The DAZAP2 protein is mainly localized in cytoplasm with a discrete pattern of punctuated distribution. DAZAP2 may associate with carcinogenesis of MM and participate in yet-to-be identified signaling pathways to regulate proliferation and differentiation of plasma cells.
Esophageal perforation after epicardial ablation: an endoscopic approach
Authors: Eduardo de Moura, Gustavo Silva, Eduardo de Moura, Leonardo Pu, Vinicius de Castro, Diogo de Moura, Rubens Sallum
Journal: Endoscopy (2015)

Endocardial ablation has long been used to treat cardiac arrhythmias. However, the indications for epicardial intervention via the pericardial space have continuously increased since the technique was first described [1] [2] [3]. A subxiphoid puncture is used to access the pericardial space ([Fig. 1 a], [Fig. 1 b]), allowing epicardial mapping and ablation ([Fig. 2 a], [Fig. 2 b]). Various complications have been described [4] [5] [6] [7] [8], which range from those caused by the puncture access (damage to the liver, colon, diaphragm, right ventricle, lungs) to those secondary to the ablation itself (damage to the coronary vessels, phrenic nerve, cardiac wall).
Privatization of psychiatric services
Authors: R A Dorwart, M Schlesinger
Journal: American Journal of Psychiatry (1988)

The authors provide an overview of privatization, a major trend in mental health policy, focusing in particular on the reasons for and consequences of substantial growth and change in ownership of private psychiatric hospitals; the proportion of all nonfederal psychiatric inpatient beds in private facilities has increased from less than 10% in 1970 to 35% today. It is estimated that between 1970 and 1986, the proportion of total nonfederal psychiatric inpatient beds in the United States that were under corporate for-profit auspices increased from about 1% to 15%. The authors distinguish and examine several aspects of privatization and assess the implications of these changes for psychiatry and for public policy and research.
Human fibroblasts produce granulocyte-CSF, macrophage-CSF, and granulocyte-macrophage-CSF following stimulation by interleukin-1 and poly(rI).poly(rC)
Authors: WE Fibbe, J Van Damme, A Billiau, N Duinkerken, E Lurvink, P Ralph, BW Altrock, K Kaushansky, R Willemze, JH Falkenburg
Journal: Blood (1988)
Gastric syphilis mimicking lymphoma
Authors: Yonghua Shen, Ling Nie, Ming Zhang, Bei Tang, Zhengyan Qin, Kui Meng, Ying Lu
Journal: Endoscopy (2015)

A 44-year-old Asian woman presented at hospital with a 3-week history of epigastric pain and early satiety. Physical examinations showed normal findings except for a minimally anemic appearance. Laboratory evaluation revealed a normal leukocyte count and serum protein level, a slight increase in the platelet count (343 × 109/L) and C-reactive protein level (13.9 mg/L), and a small decrease in hemoglobin (11.6 g/dL). Serologic tests for syphilis were positive for rapid plasmin reagin (RPR) and Treponema pallidum reagents. Serological findings for human immunodeficiency virus (HIV) were negative.
Platelet MAO activity and age at onset of depression in elderly depressed women
Authors: G S Alexopoulos, K W Lieberman, R C Young, C A Shamoian
Journal: American Journal of Psychiatry (1984)

Platelet monoamine oxidase (MAO) activity was assayed in 38 elderly depressed women and 16 matched controls. The depressed women whose illness began at age 55 or earlier (N = 19) had significantly lower MAO activity than patients with later onset (N = 19) or controls.
PTH-256 Sns for faecal incontinence following cauda equina syndrome
Authors: S Elzein, C Hoh, S Brown, C Maxwell-Armstrong
Journal: Gut (2015)

<h3>Introduction</h3> Quada Equina Syndrome can have devastating consequences. Faecal incontinence (FI) is one of these consequences. It can limit the individual’s social interactions and freedom of movement. The management of this condition ranges from incontinence products through conservative measures to surgery and colostomy as a last resort. We reviewed our management of faecalincontinence in patients with cauda equina syndrome. <h3>Method</h3> The medical notes of all patients who have undergone sacral nerve stimulator (SNS) for FI as a result of cauda equina syndrome have been reviewed and data collected. This includes patients from Nottingham university hospitals and Sheffield teaching hospitals. <h3>Results</h3> Seven patients with faecal incontinence as a result of cauda equina syndrome and one with spina-bifida have been treated in the 2 specialist centres in the UK. M:F 5:3. Median age is 38 years (31–64). One female patient did not attend multiple outpatient appointments and has therefore been discharged back to the care of her GP prior to treatment. As would be expected from the underlying aetiology, all had intact internal and external sphincters. All had failed conservative measures. One patient previously underwent PTNS to no avail. All 7 patients underwent temporary wire placement as a day case procedure. One (14.3%) patient developed a post-operative wound infection following the temporary wires insertion. They had to be removed and replaced. Six (85.7%) patient pertained &gt;50% improvement in function with the SNS implant. In one patient it resulted in 10% improvement, however the patient was insistent that it has made a great and positive impact on his quality of life. Two (28.6%) patients developed complication following permanent SNS implant. <h3>Conclusion</h3> SNS is an effective and relatively safe procedure for faecal incontinence following cauda equina syndrome. Our sample size is small but the results clearly demonstrate that SNS can work well in patients with cauda equina syndrome. <h3>Disclosure of interest</h3> None Declared.
Case 40-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Ernest H. Picard, Edward P. Richardson, James J. Galdabini
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 70-year-old woman was admitted to the hospital because of fever and obtundation.The patient was well and caring for a demented sister at home until six days earlier, when she began to feel weak and noticed a rise of the temperature to 38.9°C. Three days before admission she spoke rationally to her physician by telephone. On the following day a friend observed that she was sleepy and incoherent. One day before entry the patient was found to be drowsy and in bed; she was able to call out her sister's name and to follow a few . . .
Authors’ reply: Influenza vaccine effectiveness: heterogeneity in estimates for the 2012/13 season
Authors: K Mølbak, H D Emborg, S Gubbels, K Bragstad, T G Krause, T K Fischer
Journal: Eurosurveillance (2013)

Preview this article: Authors’ reply: Influenza vaccine effectiveness: heterogeneity in estimates for the 2012/13 season, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/7/art20401-en-1.gif
Community mental health and mental retardation services in the United States: a comparative study of resource allocation
Authors: D Braddock
Journal: American Journal of Psychiatry (1992)

Preliminary studies suggest that during the 1980s, spending for community mental retardation services in the United States may have grown much more rapidly than spending for community mental health. The primary objective of this study was to test empirically the validity of this thesis on a national basis. An additional objective was to determine why such a distinction in community spending patterns might have evolved nationally.The study used states as the units of analysis and employed a five-factor hierarchical regression to predict variance in mental health and mental retardation spending. Factors were state size, state wealth, degree of federal assistance, state civil rights activity, and strength of consumer advocacy groups. Strong roles for the civil rights and consumer advocacy factors were hypothesized. A collateral opinion survey in the 10 states exhibiting the greatest within-state difference in community mental health and mental retardation spending was also completed.Community mental retardation spending grew nearly four times more rapidly than community mental health spending in the 1980s. The consumer advocacy and civil rights factors were strongly associated with spending for community mental retardation services in the states, but these factors did not predict spending for community mental health services.Study recommendations included strengthening mental health family and consumer advocacy groups in the states and promoting systematic exchange between the mental health and mental retardation fields through joint state planning initiatives, studies, and conferences. The need for Medicaid reform is a unifying theme in both the mental health and mental retardation fields.
Peripheral Vascular Diseases
Authors: R BAUMANN
Journal: Annals of Internal Medicine (1992)

Reviews, Notes, and Listings15 March 1992Peripheral Vascular DiseasesAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-116-6-526_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractVascular problems are ubiquitious and unfortunately are also clinically difficult to identify and treat. They can range from small vasculitic lesions to limb- or life-threatening circumstances involving edema, ulceration, and gangrene of an extremity. Doctors and patients are frequently frustrated by these clinical scenarios. Unfortunately, most physicians have been poorly trained in the evaluation and treatment of these problems.Peripheral Vascular Diseases is, therefore, a much needed addition to the medical literature. The authors have made a scholarly effort in completing this text, which is derived from their years of thoughtful work with patients having peripheral vascular diseases. The book This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 March 1992Volume 116, Issue 6Page: 526-527KeywordsEdemaLesionsPeripheral vascular diseaseUlcers Issue Published: 15 March 1992 PDF downloadLoading ...
Memory reconsolidation, repeating, and working through: Science and culture in psychotherapeutic research and practice
Authors: Charles Levin
Journal: Behavioral and Brain Sciences (2015)

Abstract Hypothesizing that an effective common feature in divergent forms of psychotherapy is a process of memory reconsolidation integrating new emotional experiences, Lane et al. usefully shift the focus away from established and/or specialized techniques to deeper questions about the underlying principles of psychotherapeutic change. More research attention to cultural factors influencing the definition and treatment of psychopathology is also needed.
Treatment of ankylosing spondylitis.
Authors: Daniel O Clegg
Journal: BMJ (1978)

Ankylosing spondylitis (AS) is a condition characterized by inflammatory back pain and associated with considerable disability and diminished quality of life in affected individuals. The condition is undertreated in part due to a delay in diagnosis and limited therapeutic interventions. Although traditional treatment approaches (physical therapy, exercise, patient education, nonsteroidal antiinflammatory drugs) remain important components of the management of AS, the demonstrated efficacy of tumor necrosis factor-a (TNF-a) antagonists such as etanercept and infliximab have allowed clinicians to more effectively manage this condition. These targeted therapies have demonstrated rapid and consistent effectiveness in reducing the axial and peripheral symptoms of AS, slowing disease progression, and improving patient function and quality of life. Appropriate and timely use of TNF-a antagonists offers additional options for patients with active AS who are inadequately controlled with conventional treatment.
MULTIPLE MALIGNANT NEOPLASMS
Authors: S De Marzi, P Bernini
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pathogenesis of a Virus-Induced Leukemia in Mice
Authors: T B DUNN, J B MOLONEY, A W GREEN, B ARNOLD
Journal: JNCI Journal of the National Cancer Institute (1961)

Male BALB/c mice that received a cell-free extract from the spleens of mice with leukemia induced by a virus were compared with BALB/c mice of the same age and sex that received a cell-free extract from normal spleens. Untreated BALB/c mice were used as controls. Mice 6 weeks of age were chosen for the injections, since tissues from newborn mice are hard to handle, and a relatively low dose of virus was given to insure a gradual development of leukemia. No difference in the three groups could be detected until 8 weeks had elapsed, when many megakaryocytes containing granulocytes were observed in the bone marrow of the virus-injected mice. The next difference detected was a gradually increasing hyperplasia of the spleen in the virus-injected mice. A few mice showed a localized reticulum-cell hyperplasia in the lymph nodes. The most significant alterations appeared to be in the thymus, and, with one exception, it was in this organ that leukemia was first recognized in the treated mice. The thymus in one leukemic mouse did not contain malignant cells but showed a granulomatous reaction. A series of transplants made from the primary leukemias resulted in lymphocytic neoplasms with different biologic characteristics in regard to growth period, spread from the site of inoculation, and organ involvement. The transfer of tissue from hyperplastic spleens from mice with no morphologic evidence of leukemia reproduced the same sequence of preleukemic lesions that were observed after transfer of the cell-free extract. This study indicates that inoculation of the leukemia-inducing virus causes a derangement in certain reticular organs of mice which is conducive to the development of lymphocytic neoplasms. The virus described by Moloney may be acting like many other carcinogenic agents. Several incidental lesions appearing in experimental, control, and stock BALB/c mice are described.
Director of Medical Education
Authors: N M ALTER
Journal: BMJ (2008)

College of Forensic Psychiatry in Newport Beach, California.Keckich reporled a single case of violence, as a manifestation of akathisia, in which a man assaulted his dog with an intent to kill following treatment with low dose haloperidol in combination with impramine.1 Most clinicians have observed adverse CNS effects, of a mild to severe degree, to often occur in the first few days of treatment with high potency, low dose neuroleptic medications.Parkinsonian or extrapyramidal side effects, in patients under reELrlar treatment with currently popular neuroleptics, generally are found to be reduced and become less severe with reduction of dose or addition of antiparkinsonian aqents.Neuromuscular reactions such as motor restlessness, dystonia, akathisia, hyperreflexia, opisthotonos and oculogyric crists have been reported as occurring less frequently, but oftcn being very severe requiring discontinuation of the drug at times and, occasionally emergency room treatment.These agents (especially haloperidol) are increasinqly being used in emergency roonrs, hospital wards, and other settings for the raprd nnn*rnl ^{ ^^;+û (rrr L.,r (rr ..y,,..ted and violepl ncrrnlrntin a\/rnptoms and belravior.
PWE-109 Bleeding the bronze diabetics:prospective audit against local, national and european guidelines of venesection in hereditary haemochromatosis at a district general hospital in scotland
Authors: M Johnston, A El Nujumi
Journal: Gut (2015)

<h3>Introduction</h3> Patients with haemochromatosis and evidence of iron excess should be treated with venesection. This confers a normal life expectancy in the absence of cirrhosis and diabetes. Over 400 patients regularly attend Wishaw for venesection. We aimed to document haemoglobin and ferritin; and whether venesection is done based on these results. We additionally checked genotype. <h3>Method</h3> Prospective audit of all gastroenterology patients with hereditary haemochromatosis attending for venesection over 7 weeks. Results compared against local, BCSH and EASL guidelines. <h3>Results</h3> There were 61 attendances by 41 patients. Ferritin was regularly checked but 6 patients were venesected despite already achieving the target (&lt;50 μg/L). 6 patients did not have haemoglobin checked before venesection. 8 patients were venesected despite low haemoglobin. 25 of 41 patients had been genotyped. Liver biopsy had been performed in only 2 of 11 patients in whom it was indicated. <h3>Conclusion</h3> There is scope to improve safe venesection based on ferritin and haemoglobin. There was variation in how aggressively patients were venesected in clinic. One contributing factor is thought to be the differing target values used by haematologists and gastroenterologists in the hospital. In an attempt to address this the venesection protocol is to be standardised across patients. This is a popular change with venesection clinic staff. Another factor is that patients9 individual venesection booklets do not follow their case notes to clinic appointments. This would allow clinicians to monitor patients9 venesection more actively. <h3>Disclosure of interest</h3> None Declared.
Heparin-Induced Thrombocytopenia
Authors: Naomi B Klarenbeek, Jeroen C J Eikenboom
Journal: New England Journal of Medicine (2015)

Heparin-induced thrombocytopenia (HIT), typically occurring in the second week of heparin therapy, is an antibody-mediated adverse drug reaction associated with increased thrombotic risk. The most important antigens are located on platelet factor 4 (PF4)/heparin complexes. All HIT is caused by platelet-activating antibodies, but not all PF4/heparin-reactive antibodies cause HIT. Thus, tests have high negative, but only moderate, positive predictive value. Cessation of heparin requires substitution with an alternative anticoagulant, but as these drugs have increased bleeding risk, they should be used in therapeutic doses only if HIT is considered very likely. Avoiding/postponing coumarin is crucial in minimizing microthrombotic complications. Recent studies of HIT immunobiology suggest that HIT mimics immunity against repetitive antigens, as they are relevant in microbial defense. Thus, understanding HIT may help unravel why host defenses can trigger autoimmunity.
EPIG-05RADIORESISTANCE OF PODOPLANIN-EXPRESSING GLIOMA STEM CELLS IS ASSOCIATED WITH EZH2-DRIVEN POLYCOMB REPRESSIVE COMPLEX ACTIVITY
Authors: Eskil Eskilsson, Qianghu Wang, Ravesanker Ezhilarasan, Krishna P. Bhat, Ming Tang, Lindsey D. Goodman, Kenneth D. Aldape, Roeland G. Verhaak, Erik P. Sulman
Journal: Neuro-Oncology (2015)

Glioblastoma (GBM) is the most frequently occurring malignant primary tumor of the central nervous system, and despite aggressive clinical intervention, GBM is uniformly fatal. Data from multiple expression profiling experiments suggest that the type-I integral membrane glycoprotein podoplanin (PDPN) is an important prognostic marker in astrocytic gliomas independent of a number of relevant clinical factors. We recently discovered that radiotherapy (RT) resistance of GBM is associated with global DNA hypermethylation and hypothesized that PDPN may be involved in this phenomenon. Indeed, we found that PDPN knockdown sensitized glioma sphere-forming cells (GSCs) to RT in vitro. Furthermore, upon profiling PDPN-sorted GSC subpopulations, enrichment analysis revealed that PDPN upregulates polycomb repressive complex (PRC) activity to promote EZH2-driven global DNA hypermethylation. EZH2 is known to directly control DNA methylation, and we have previously shown that EZH2 protects GSCs from radiation-induced cell death. This is the first report implicating PDPN in EZH2-mediated RT resistance, and we believe the membrane protein may be a meaningful therapeutic target in RT resistant GBM. In summary, PDPN is a novel prognostic marker for individuals with astrocytic gliomas and promotes EZH2-mediated RT resistance in GSCs.
Camptothecin Hypersensitivity in PoIy(Adenosine Diphosphate-Ribose) Polymerase-Deficient Cell Lines
Authors: S Chatterjee, M F Cheng, D Trivedi, S J Petzold, N A Berger
Journal: Cancer Communications (1989)

Mutant cell lines, derived from the Chinese hamster V79 cell line, deficient in poly(adenosine diphosphate-ribose) polymerase activity, and previously shown to be resistant to topoisomerase II inhibitors, were found to be hypersensitive to camptothecin, a topoisomerase I inhibitor. In all the cell lines, camptothecin induced dose-dependent protein-associated DNA single-strand breaks and sister chromatid exchanges. The increased sensitivity to camptothecin-induced cytotoxicity was not associated with an increase in DNA single strand breaks or sister chromatid exchanges. These results suggest the absence of any direct causal relation between (1) camptothecin induced sister chromatid exchanges and cytotoxicity or (2) camptothecin induced DNA strand breaks and cytotoxicity. The hypersensitivity of these mutant cell lines to camptothecin suggests that poly(adenosine diphosphate-ribose) polymerase is involved with topoisomerase I in modulating camptothecin induced cytotoxicity.