tbuckley/cabot-search huggingface dataset:
Indian health groups welcome country's first compulsory licence
Authors: G. Mudur
Journal: BMJ (2012)

India’s controller of patents has granted the country’s first compulsory licence on a patented drug, allowing a domestic drug company to manufacture a generic version of Bayer’s sorafenib tosylate (marketed as Nexavar), used in chemotherapy for hepatic and renal cancers.

Natco Pharma asked for the right to manufacture sorafenib tosylate, saying that it would make available a generic version that would cost patients 8800 rupees (£110; €135; $175) a month rather than the 280 000 rupees a month it costs for Bayer’s product. The controller granted the licence and ruled that Natco Pharma should pay Bayer a royalty fee of 6% on sales of the generic version.

Experts in public health who have been campaigning for better access to inexpensive generic drugs have hailed the controller’s decision, but sections of the pharmaceutical industry have said that compulsory licensing should be invoked …
Abstract IA21: Role of Tet1-catalyzed 5mC hydroxylation in transcriptional regulation and ES cell maintenance
Authors: Yi Zhang, Chevy Chase
Journal: Cancer Research (2011)

Abstract Epigenetic modifications play important roles in diverse biological processes that range from regulation of gene expression, embryonic development, stem cell reprogramming, and human diseases such as cancers. One of the epigenetic modifications is DNA methylation. Although enzymes responsible for DNA methylation have been well characterized, enzymes responsible for active DNA demethylation in mammalian cells have remained elusive. Recent studies have demonstrated that a novel family of proteins— Tet1–3—have the capacity to convert 5mC to 5hmC, raising the possibility that Tet proteins may catalyze the initial step leading to DNA demethylation. Interestingly, Tet1 plays an important role in stem cell self-renewal and maintenance. To understand how Tet1 contributes to these processes, we profiled the genome-wide location of Tet1 and 5hmC in ES cells. This study revealed that Tet1 has a dual function in activating pluripotency stem cell genes and silencing lineage-specific differentiation genes. Further studies revealed that Tet1 contributes to gene silencing by facilitating recruitment of PRC2. Thus, our studies establish a link between Tet1 and PRC2 and revealed a dual function for Tet1 and 5hmC in transcriptional regulation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the Second AACR International Conference on Frontiers in Basic Cancer Research; 2011 Sep 14-18; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2011;71(18 Suppl):Abstract nr IA21.
Prominent Imaging of the Liver on Bone Densitometry
Authors: I Ak, E Entok, E Vardareli
Journal: Clinical Nuclear Medicine (2000)

A 71-year-old woman had a bone densitometry examination because of weakness and bone pain lasting 3 months. The liver was coincidentally imaged in the right upper quadrant in this examination. Widespread calcifications were evident in the liver. Later, an abdominal ultrasound showed massive, irregular calcifications in the liver. Papillary thyroid carcinoma metastases were proved by the psammoma bodies, papillary arrangement, and calcifications seen on the liver biopsy.
Abstract 2219: Inhibitor of differentiation-1 is a novel prognostic factor among NSCLC patients with adenocarcinoma histology and contributes to therapy resistance
Authors: Mariano Ponz-Sarvise, Paul A. Nguewa, Maria J. Pajares, Jackeline Agorreta, Maria D. Lozano, Miriam Redrado, Ruben Pio, Carmen Behrens, Ignacio Wistuba, Jesus Garcia-Foncillas, Luis M. Montuenga, Alfonso Calvo, Ignacio Gil-Bazo
Journal: Cancer Research (2011)

Abstract High Id1 levels have been found in some tumor types, particularly in advance stages. We aimed to study Id1 levels and their prognostic value in a large series of different histologies of stage I-IV NSCLC patients and to test Id1 function in cell lines and cells derived from malignant pleural effusions (MPE) from patients (pts). Id1 expression was analyzed in NSCLC samples from 311 pts and 65 normal lung tissues by immunohistochemistry. Id1 mRNA expression was also studied in 111 pts using publicly available microarrays. Significantly higher Id1 protein expression levels were found in tumors compared to normal tissue (p&amp;lt;0.001) and in adenocarcinomas (AC) compared so squamous histology (p&amp;lt;0.001). Among the localized NSCLC pts undergoing surgery, higher Id1 expression levels were associated with a shorter overall survival (OS) for AC histology (p=0.017). In the surgery+adjuvant chemo-radiotherapy pts, the same correlation was found between Id1 levels and OS among AC samples (p=0.038). Consistently, in stage IV pts receiving palliative chemotherapy, Id1 maintained its prognostic value (shorter OS in pts with higher levels) for AC (p=0.003). Id1 was also correlated with time-to-progression (TTP) after chemotherapy (lower levels, prolonged TTP) in AC pts (p=0.008). The in silico analysis confirmed this association. High expression of Id1 was also found by western blots in squamous cell lines (H520, HCC15, H157 and H58) and in lesser extent in AC cell lines (SKLU-1, LXF-289, H322, H23) and MPE-derived AC cells. Id1 knockdown resulted in a significant reduction of the clonogenic activity of squamous and AC cells. Id1 silencing on radiotherapy and chemotherapy-resistant MPE-derived cells restored sensitivity to both therapies. We conclude that Id1 protein and mRNA expression is an independent prognostic factor among pts with AC but no other histologies, regardless of the stage or treatment received. In cell lines derived from MPE pts, Id1 downregulation decreases NSCLC cell proliferation and sensitizes cells to radiotherapy and chemotherapy, in vitro. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2219. doi:10.1158/1538-7445.AM2011-2219
Abstract 135: Integrated analysis of cell signaling pathway-associated miRNAs using protein expression array data in NCI-60 cells
Authors: Sang-Bae Kim, Yun-Yong Park, Bo-Hwa Sohn, Woojin Jeong, Sung Sook Lee, Ji Hoon Kim, Micheal A. Davies, Gordon B. Mills
Journal: Cancer Research (2012)

Abstract MicroRNAs (miRNAs) are single-stranded, non-coding RNA molecules and on average only 22 nucleotides long that regulate gene expression at the post-transcriptional level. The current approaches with miRNA-mRNA association were not enough to verify real functional targets at protein level, which could affect on biological signaling pathway. In this study, we developed a correlation based approach (sequence-independence) to predict potential miRNA targets with genomic and proteomic data including the expression of phosphorylated proteins in NCI-60 cells. To do this we calculated the number of correlated probe-pairs between miRNA(439)-mRNA(22k) and protein(222)-mRNA probe pairs. Then, two significant output pair sets were combined by mRNA probes and then counted the number of common probes. With these count numbers, finally we generated Association score matrix between miRNA and protein probes. Using those score matrix, we evaluated the highly associated miRNAs with 36 biological pathways, which play critical roles in cell cycle, proliferation and metastasis. Among these associations, we found that miR-500 cluster is highly associated with ERK/MAPK signaling pathway through activating MEK1/2 phosphorylation in Melanoma and breast cancer cells. In conclusion, we developed a novel expression profile based approach to systematically predict potential miRNA functional targets which play critical roles in cell signaling pathways from the NCI-60 genomic and proteomic data at whole genomic scale. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 135. doi:1538-7445.AM2012-135
P854 PARENCHYMAL MEASURED FAT PROPORTIONATE AREA COULD NOT EXPLAIN THE ABNORMAL TRANSAMINASES IN NAFL PATIENTS
Authors: P. Manousou, A. Hall, A. Green, E. Tsochatzis, K. Mantzoukis, V. Papastergiou, E. Thalassinos, A.K. Burroughs, A.P. Dhillon
Journal: Journal of Hepatology (2014)
Abstract 3443: Targeting G2/M cell cycle regulators in medulloblastoma tumor-propagating cells
Authors: Shirley L. Markant, Kelly Barton, Jesse Sun, Robert Wechsler-Reya
Journal: Cancer Research (2011)

Abstract Medulloblastoma is the most common malignant brain tumor in children. While the current treatment strategy of surgery, radiation and chemotherapy has a 60-80% cure rate, the survivors suffer severe side effects, including growth delays and cognitive deficits. Therefore, more effective, less toxic treatments are needed. One approach to achieving this is targeting the cells within a tumor that are capable of re-populating the tumor, known as tumor-propagating cells (TPCs). In the patched mutant mouse model of medulloblastoma, TPCs are marked by expression of the cell surface carbohydrate antigen CD15. Our previous studies suggest that CD15+ cells display increased expression of genes associated with G2/M phase of the cell cycle. Cell cycle analysis suggests that these CD15+ cells move quickly through the G1 and S phases of the cell cycle, but accumulate in G2/M phase. Therefore, inhibition of G2/M regulators, such as Aurora kinases, may represent one approach to targeting TPCs in these tumors. Treatment of tumor cells with the Aurora kinase inhibitor VX-680 (tozasertib) leads to inhibition of proliferation in vitro, with arrest in G2/M and apoptosis. Preliminary studies suggest that patched mutant tumors are also sensitive to Aurora kinase inhibition in vivo. Our findings suggest that targeting Aurora kinases may represent a novel approach for the treatment of hedgehog-associated human medulloblastoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3443. doi:10.1158/1538-7445.AM2011-3443
OUTCOMES OF PERIPROCEDURAL ANTICOAGULATION THERAPY WITH WARFARIN VERSUS NEW ORAL ANTICOAGULANTS IN PATIENTS UNDERGOING CARDIAC IMPLANTABLE ELECTRONIC DEVICE PLACEMENT
Authors: Lena Trager, Cesar Martinez, Ross Garberich, Tamara Langeberg, Jay Sengupta, Leah Kupiers, JoEllyn Abraham, Raed Abdelhadi
Journal: Journal of the American College of Cardiology (2016)
PLASMA CYSTATIN C IN RELATION TO CORONARY ATHEROSCLEROSIS ON INTRAVASCULAR ULTRASOUND AND CARDIOVASCULAR OUTCOME: IMPACT OF KIDNEY FUNCTION (ATHEROREMO-IVUS STUDY)
Authors: Milos Brankovic, K.M. Akkerhuis, Jin Cheng, Rohit Oemrawsingh, Hector Garcia Garcia, Evelyn Regar, Patrick Serruys, Robert van Geuns, Eric Boersma, Isabella Kardys
Journal: Journal of the American College of Cardiology (2016)
SM-04 * PROPHYLACTIC ANTIEPILEPTIC DRUGS DO NOT REDUCE SEIZURE RATES IN SURGICAL BRAIN TUMOR PATIENTS
Authors: D. Lockney, F. Walch, S. Vaziri, M. Rahman, G. Murad
Journal: Neuro-Oncology (2014)

Though no clear evidence supports seizure prophylaxis in patients with cerebral tumors, prophylactic use of anti-epileptic drugs (AEDs) for patients undergoing tumor surgery is common practice. A retrospective chart review was performed of 609 consecutive patients from 2010-2013 who underwent surgery for brain neoplasms at the University of Florida. Patients who did not present with seizures preoperatively were divided into supratentorial and infratentorial groups. There were 357 patients with supratentorial tumors with 297 (83.2%) receiving AEDs post-operatively and 60 (16.8%) not receiving AEDs. From surgery to last follow-up, one patient (2%) in the non-AED group had a seizure and 15 (6.2%) in the AED group had seizures (p = 0.487). There were 129 patients with infratentorial tumors, with 32 (24.8%) receiving AEDs and 97 (75.2%) not receiving AEDs. In the post-operative period, one patient (1.2%) in the non-AED group had a seizure and zero in the AED group had a seizure (p = 1). 16 (5.4%) patients in the supratentorial group and 3 (9.4%) patients in the infratentorial group on AEDs experienced toxicity related to AEDs. At discharge, 254 patients (85.5%) with supratentorial tumors without seizures remained on AEDs. At last follow up, 129 patients (53.8%) with supratentorial tumors remained on AEDs despite no seizures. AEDs do not significantly reduce post-operative seizures in surgical brain tumor patients in this analysis. Additionally, once a patient is prescribed an AED, discontinuation of AED therapy is unlikely, even if the patient remains seizure free.
DRUG-ELUTING STENT SHOWED BETTER CLINICAL OUTCOME THAN BARE-METAL STENTS IN TRANS-ATLANTIC INTER-SOCIETY CONSENSUS II CLASS A-C LESIONS IN THE FEMOROPOPLITEAL ARTERY
Authors: Kiyonori Nanto, Osamu Iida, Masashi Fujita, Masaharu Masuda, Shin Okamoto, Takayuki Ishihara, Takashi Kanda, Tatsuya Shiraki, Akihiro Sunaga, Takuya Tsujimura, Shota Okuno, Yasuhiro Matsuda, Koji Yanaka, Masaaki Uematsu
Journal: Journal of the American College of Cardiology (2015)
1306 LYSOSOMAL ENZYMES: A NOVEL NON-INVASIVE APPROACH TO DETECT HEPATIC INFLAMMATION IN NASH
Authors: S.M. Walenbergh, V. Bieghs, T. Hendrikx, P.J. van Gorp, M.L. Jeurissen, F. Verheyen, P. Lindsey, J. Plat, A.C. Vreugdenhil, S.S. Rensen, W.A. Buurman, J.W.M. Greve, G.H. Koek, M.H. Hofker, R. Shiri-Sverdlov
Journal: Journal of Hepatology (2013)
An examination of the borderline diagnosis in children
Authors: D A Greenman, J G Gunderson, M Cane, P R Saltzman
Journal: American Journal of Psychiatry (1986)

A retrospective study of 86 children aged 6-12 years who had been hospitalized for psychiatric reasons revealed that adult criteria for borderline personality disorder could identify a group of children with many of the features attributed in the literature to the borderline child. The relative paucity of significant differences between the children identified as borderline and those identified as nonborderline raises questions about the validity and utility of the term. Further work is necessary to clarify the meaning of a vulnerability to psychotic regression in the disturbed child and the relation of such a vulnerability to the adult borderline personality disorder.
Abstract LB-63: From the Golf Course to Education: Outreach &amp; Support for Prostate Cancer
Authors: Egbert Brown
Journal: Cancer Research (2011)

Abstract Central Ohio Men Against Prostate Cancer provides access to education, outreach and support for diagnosed or at-risk prostate cancer patients, their families, and friends. There is extensive medical information available online and through healthcare providers. The organization's goal is to help people connect with resources that can help them become more aware of prostate cancer, better informed about treatment options, and lead men to seek early screening for prostate cancer. Prostate cancer is the second leading cause of deaths in African American men. It was estimated that 3,690 deaths from prostate cancer would occur in African American men in 2009. African American men have the highest mortality rate for prostate cancer of any racial or ethnic group in the U.S. An estimated 27,130 cases of prostate cancer were expected to occur among African American men in 2009, accounting for 34 percent of all cancers diagnosed in African American men. Between 2001–2005, the average annual prostate cancer incidence rate was 59 percent higher in African American men than in white men. Numerous studies have shown that education and support have an impact on the decision of individuals to be screened for prostate cancer, resulting in early detection and diagnosis. The Central Ohio Men Against Prostate Cancer organization was founded in 2004 by a group of African American gentlemen who were golfing buddies. Since its inception, the group has raised awareness of prostate cancer among all men living in Central Ohio through education, outreach and fundraising. An annual golf tournament has donated funds to the Columbus Cancer Clinic to help cover costs of digital rectal examinations and prostate specific antigen tests for underserved men. The advocacy efforts of the group have extended to participation in national initiatives for prostate cancer, including memberships in the US Too National Prostate Cancer Education and Support Team, memberships in the National Association of Prostate Cancer Advocates, and service as an ad- hoc member of the U. S. Army Research and Materials Command Prostate Cancer Research Program. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-63. doi:10.1158/1538-7445.AM2011-LB-63
Colorectal Cancer Screening
Authors: ROBERT A. CLARK, ROBERT D. HALPERT
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Colorectal Cancer Screening Get access ROBERT A. CLARK, ROBERT A. CLARK Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT D. HALPERT ROBERT D. HALPERT Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 14, 17 July 1991, Page 1034, https://doi.org/10.1093/jnci/83.14.1034 Published: 17 July 1991
Nouvelle capsule SB2/4 (4 images/s): intérêt clinique et comparaison de plusieurs modes de lecture
Authors: M Delvaux, G Gay, C Duburque, B Filoche, C Savalle, J Edrry, C Cellier, JL Gaudin, JC Saurin, D Monges, P Grandval, R Laugier
Journal: Endoscopy (2011)

Introduction: La capsule endoscopique SB2/4 constitue une évolution technique de la capsule SB (Given Imaging, Yoqneam, Israël). Elle acquiert 4 images par seconde, contre 2 pour la capsule SB2. Le but de cette étude était donc d'évaluer le gain diagnostique de la capsule SB2/4 par rapport à la capsule SB2 et de comparer plusieurs modes de lecture.
Impact of Geriatric Assessment on Treatment Decisions and Follow-Up in Older Colorectal Cancer Patients
Authors: Leen Vanacker, Cindy Kenis, Godelieve Conings, Koen Milisen, Hans Prenen, Jacques Van der Auwera, Eric Van Cutsem, Katrien Van Puyvelde, Johan Flamaing, Jean Pierre Lobelle, Jacques De Grève, Hans Wildiers, Lore Decoster
Journal: Annals of Oncology (2013)
Therapy for Acne Vulgaris
Authors: James J. Leyden
Journal: New England Journal of Medicine (1997)

Acne vulgaris, or acne, as it is generally called, is the most common skin disease, affecting nearly 80 percent of persons at some time between the ages of 11 and 30 years.1 It can persist for years and result in disfigurement and permanent scarring, and it can have serious adverse effects on psychosocial development, resulting in emotional problems, withdrawal from society, and depression.2 The pathogenesis of acne is multifactorial, and therapy can now be directed at many of these factors. This review summarizes current concepts of the rational treatment of acne vulgaris.Pathophysiology of AcneAcne vulgaris is the result . . .
Abstract 1205: Frequent detection of MDMX isoforms in human ovarian carcinomas
Authors: Claudia Loebel, Anja Wolf, Julia Richter, Christoph Thomssen, Steffen Hauptmann, Frank Bartel
Journal: Cancer Research (2010)

Abstract The p53 tumor suppressor pathway is inactivated in many human tumors either by p53 mutations or through overexpression of negative regulators, such as MDM2 and MDMX. In analogy to MDM2, besides the full-length mRNA several transcript variants, alternatively, as well as, aberrantly spliced transcripts of MDMX have been identified in different tumor cell lines. However, so far there are no studies regarding the expression of MDMX transcript variants in ovarian cancer tissue samples. We therefore screened 34 snap frozen ovarian tumor samples, using a high-temperature First-Strand cDNA synthesis kit to avoid reverse transcriptase artefacts. We identified in addition to MDMX-S numerous new MDMX transcripts in 16 of the 34 tumor samples that were either spliced at genuine exon/intron boundaries or at cryptic splice sites within exons. Furthermore, we could detect the transcript variants MDMX-A and MDMX-XALT2 firstly in ovarian cancer tissue. The MDMX splice variants can be classified into two groups: some isoforms have only retained the p53 binding domain, such as MDMX-S; in contrast, other splice forms consist of an intact C-terminus including the RING-finger domain, such as MDMX-XALT2. In addition, we have analyzed the expression of MDMX splice forms in ovarian cancer cell lines after treatment with chemotherapeutic agent. We observed a significant increase of the MDMX-S splice form while the expression levels of full-length MDMX decreased. This suggests that MDMX splice forms may play a role in mediating chemoresistance by attenuating the p53-pathway. In ongoing studies, we are investigating the role of frequently detected MDMX splice forms regarding their impact on chemoresistance in ovarian cancer in more detail. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1205.
Abstract 5233: Modeling ionizing radiation exposure in vitro and in vivo using the Virtual Tumour.
Authors: Eric Fernandez, David Orrell, Frances Brightman, David Fell, Christophe Chassagnole
Journal: Cancer Research (2013)

Abstract Ionizing radiation exposure induces DNA double strand breaks in mammalian cells. In response, cells activate repair mechanisms which involve cell cycle arrest at discrete transition points of the cell cycle. The results in an accumulation of cells in S and G2 phase in an irradiated cell population over a period of time following exposure. Using the Virtual Tumour, a cell population simulator of cancer cells and tissue, we have built a model of irradiation of tumour cell culture in vitro as well as tumour tissue in vivo for various cancer cell types. We show how cell cycle timings and radiosensitivity can accurately reproduce both in vivo and in vitro response to irradiation-induced DNA damage. We also study how the radiosensitization effect of gemcitabine is time-dependent. This demonstrates how the Virtual Tumour can help maximise therapeutic efficacy of combinations involving irradiation. Citation Format: Eric Fernandez, David Orrell, Frances Brightman, David Fell, Christophe Chassagnole. Modeling ionizing radiation exposure in vitro and in vivo using the Virtual Tumour. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5233. doi:10.1158/1538-7445.AM2013-5233