tbuckley/cabot-search huggingface dataset:
An interaction map of circulating metabolites, immune gene networks, and their genetic regulation
Authors: Artika P. Nath, Scott C. Ritchie, Sean G. Byars, Liam G. Fearnley, Aki S. Havulinna, Anni Joensuu, Antti J. Kangas, Pasi Soininen, Annika Wennerström, Lili Milani, Andres Metspalu, Satu Männistö, Peter Würtz, Johannes Kettunen, Emma Raitoharju, Mika Kähönen, Markus Juonala, Aarno Palotie, Mika Ala-Korpela, Samuli Ripatti, Terho Lehtimäki, Gad Abraham, Olli Raitakari, Veikko Salomaa, Markus Perola, Michael Inouye
Journal: Genome biology (2017)

Immunometabolism plays a central role in many cardiometabolic diseases. However, a robust map of immune-related gene networks in circulating human cells, their interactions with metabolites, and their genetic control is still lacking. Here, we integrate blood transcriptomic, metabolomic, and genomic profiles from two population-based cohorts (total N = 2168), including a subset of individuals with matched multi-omic data at 7-year follow-up. We identify topologically replicable gene networks enriched for diverse immune functions including cytotoxicity, viral response, B cell, platelet, neutrophil, and mast cell/basophil activity. These immune gene modules show complex patterns of association with 158 circulating metabolites, including lipoprotein subclasses, lipids, fatty acids, amino acids, small molecules, and CRP. Genome-wide scans for module expression quantitative trait loci (mQTLs) reveal five modules with mQTLs that have both cis and trans effects. The strongest mQTL is in ARHGEF3 (rs1354034) and affects a module enriched for platelet function, independent of platelet counts. Modules of mast cell/basophil and neutrophil function show temporally stable metabolite associations over 7-year follow-up, providing evidence that these modules and their constituent gene products may play central roles in metabolic inflammation. Furthermore, the strongest mQTL in ARHGEF3 also displays clear temporal stability, supporting widespread trans effects at this locus. This study provides a detailed map of natural variation at the blood immunometabolic interface and its genetic basis, and may facilitate subsequent studies to explain inter-individual variation in cardiometabolic disease.
Drug-Repositioning Screens Identify Triamterene as a Selective Drug for the Treatment of DNA Mismatch Repair Deficient Cells
Authors: Delphine Guillotin, Philip Austin, Rumena Begum, Marta O. Freitas, Ashirwad Merve, Tim Brend, Susan Short, Silvia Marino, Sarah A. Martin
Journal: Clinical Cancer Research (2016)

Abstract Purpose: The DNA mismatch repair (MMR) pathway is required for the maintenance of genome stability. Unsurprisingly, mutations in MMR genes occur in a wide range of different cancers. Studies thus far have largely focused on specific tumor types or MMR mutations; however, it is becoming increasingly clear that a therapy targeting MMR deficiency in general would be clinically very beneficial. Experimental Design: Based on a drug-repositioning approach, we screened a large panel of cell lines with various MMR deficiencies from a range of different tumor types with a compound drug library of previously approved drugs. We have identified the potassium-sparing diuretic drug triamterene, as a novel sensitizing agent in MMR-deficient tumor cells, in vitro and in vivo. Results: The selective tumor cell cytotoxicity of triamterene occurs through its antifolate activity and depends on the activity of the folate synthesis enzyme thymidylate synthase. Triamterene leads to a thymidylate synthase-dependent differential increase in reactive oxygen species in MMR-deficient cells, ultimately resulting in an increase in DNA double-strand breaks. Conclusions: Conclusively, our data reveal a new drug repurposing and novel therapeutic strategy that has potential for the treatment of MMR deficiency in a range of different tumor types and could significantly improve patient survival. Clin Cancer Res; 23(11); 2880–90. ©2016 AACR.
Genetic Factors Related with Early Onset of Osteonecrosis of the Jaw in Patients with Multiple Myeloma Under Zoledronic Acid Therapy
Authors: Pelagia Melea, Tina Bagratuni, Evangelos Terpos, Evangelos Eleutherakis-Papaiakovou, Maria Gavriatopoulou, Ioannis Melakopoulos, Efstathios Kastritis, Meletios A. Dimopoulos
Journal: Blood (2014)
Mutational Status in Genes of Folate Metabolism Is Associated with Toxicity of High-Dose Methotrexate in Patients with Immunocompetent Primary Central Nervous System Lymphoma.
Authors: Stefan Knop, Markus Guenther, Juergen Loeffler, Agnieszka Korfel, Michael Weller, Hermann Einsele, Holger Hebart, Ulrich Herrlinger
Journal: Blood (2006)
Insuline-Like Growth Factor 1 Is over Expressed in Multiple Myeloma Plasma Cells and Regulates the Expression of the Insuline-Like Growth Factor 1 Receptor.
Authors: C. Terragna, M. Renzulli, N. Testoni, T. Grafone, P. Tosi, E. Zamagni, C. Cellini, E. Ottaviani, S. Colarossi, I. Iacobucci, A. Poerio, G. Martinelli, M. Baccarani, M. Cavo
Journal: Blood (2005)
Haploidentical Hematopoietic Stem Cell Transplantation of Sex-Matched Donor-Recipient Pair Has Survival Advantage: A Single-Center Study of 440 Cases
Authors: Tong Wu, Yan-Li Zhao, Jing-Bo Wang, Xing-Yu Cao, Yu-Ming Yin, Yuan Sun, Yue Lu, Jia-Rui Zhou, Yan-Qun Gao, Wan-Ming Da, Shu-Quan Ji, Yao-Chen Zhang, Dao-Pei Lu
Journal: Blood (2010)
Doctors’ relationships with managers are being eroded by pressure on the NHS
Authors: Abi Rimmer
Journal: BMJ (2016)

NHS pressures are undermining relationships between doctors and managers, a study conducted by the Nuffield Trust has found.1

The Nuffield Trust surveyed 472 leaders and clinicians in management. It found that while hospital managers and senior doctors were working together better than they had in the past, relationships had been damaged by reorganisation and financial pressures.

Of …
PARP Inhibitors in Ovarian Cancer Treatment
Authors: David R. Spriggs, Dan L. Longo
Journal: New England Journal of Medicine (2016)

A paradox of DNA biology is that sequence integrity must be maintained in order for the organism to maintain life and normal functions, yet evolution requires some variability in gene expression so that changes that are more adaptive are positively selected. Indeed, more highly evolved species have developed an immune system that protects organisms against the world of dangers as a direct consequence of focusing DNA mutation on a particular subset of genes that encode for antigen receptors. However, in general, environmental and biologic insults that disrupt the DNA sequence (and there are many of these, including ultraviolet light, mutagens . . .
High-Dose Sequential Chemotherapy (HDSC) in Support of Autologous Stem Cell Transplantation (ASCT) in Patients with Relapsed/Refractory Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL).
Authors: Basak Oyan, Yener Koc, Evren Ozdemir, Emin Kansu
Journal: Blood (2004)
Renal Failure in Multiple Myeloma: Incidence, Correlations and Prognostic Significance.
Authors: Vangelis Eleftherakis-Papaiakovou, Athanasios Anagnostopoulos, Aristotelis Bamias, Dimitra Gika, Argiris Symeonidis, Anastasia Pouli, Nikolaos Anagnostopoulos, Konstantinos Zervas, Evridiki Michali, Efstathios Kastritis, Meletios A. Dimopoulos
Journal: Blood (2006)
Religious Service Attendance and Suicide Rates—Reply
Authors: Tyler J. VanderWeele, Shanshan Li, Ichiro Kawachi
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Impaired Mobilization of Peripheral Blood Stem Cell (PBSC) after Fludarabine Treatment: Comparison of Results Using 3 Different Procedures.
Authors: Philippe Genet, Philippe Travade, Bruno Cazin, Stephane Lepretre, Marine Divine, Claude Martin, Veronique Leblond, Eric Van Den Neste, Frederic Maloisel, Mauricette Michallet, Houchingue Eghbali, Christian Berthou, Alain Delmer, Bernard Grosbois, Pierre Feugier, Michel Leporrier, Laurent Sutton, Olivier Tournilhac
Journal: Blood (2005)
Intrinsic and Extrinsic Survival Signals Converge on STAT3 As a Critical Mediator of BCR-ABL-Independent Tyrosine Kinase Inhibitor Resistance,
Authors: Anna M Eiring, Ira L Kraft, David J Anderson, Elie Traer, Qian Yu, Jamshid Khorashad, Thomas O'Hare, Michael W. Deininger
Journal: Blood (2011)
Velocity of Early BCR-ABL Transcript Elimination As an Optimized Predictor of Deep Molecular Response in Chronic Myeloid Leukemia Patients in Chronic Phase on Treatment with Dasatinib
Authors: Kazunori Murai, Kohei Yamaguchi, Shigeki Ito, Tomoaki Akagi, Kazuei Ogawa, Inomata Mitsue, Kuniaki Meguro, Reiko Watanabe, Takuto Miyagishima, Kentaro Wakasa, Motohiro Shindo, Yasuhiko Tsukushi, Kohmei Kubo, Koji Oba, Junichi Sakamoto, Yoji Ishida
Journal: Blood (2015)
Dissection of Submicroscopical Aberrations and Clonal Evolution from Birth To Diagnosis and Relapse in a Childhood AML FLT3-ITD Positive Patient by RQ-PCR and SNP Array Analyses.
Authors: Giovanni Cazzaniga, Silvia Bungaro, Manoj Raghavan, Chiara Beretta, Maria G. Dell’Oro, Lucilla Lecchi, Vincenzo Rossi, Paolo Rebulla, Bryan D. Young, Andrea Biondi
Journal: Blood (2005)
Molecular Cytogenetic Study of Immunofluorescently Labeled Plasma Cells and Prognostic Significance of Clonal Chromosomal Aberrations in Multiple Myeloma.
Authors: Kyra Michalova, Zuzana Zemanova, Lenka Pavlistova, Jana Tajtlova, Ivan Spicka, Rene Zounar, Evzen Gregora, Alena Smolikova, Michal Chrz, Jarmila Obernauerova, Lenka Walterova
Journal: Blood (2006)
The Monoclonal Antibody nBT062 Conjugated to Cytotoxic Maytansinoids Has Potent and Selective Cytotoxicity against CD138 Positive Multiple Myeloma Cells in Vitro and in Vivo.
Authors: Hiroshi Ikeda, Teru Hideshima, Robert J. Lutz, Sonia Vallet, Samantha Pozzi, Loredana Santo, Elisabetta Calabrese, Benjamin Dälken, Christoph Uherek, Silke Aigner, Frank Osterroth, Mariateresa Fultiniti, Yutaka Okawa, Giulia Perrone, Gullu Gorgun, Hiroshi Yasui, Diana Cristia, Noopur Raje, Nikhil Munshi, Paul Richardson, Kenneth C. Anderson
Journal: Blood (2008)
A Phase I Trial of Ara-C, Topotecan, and Gemtuzumab Ozogamicin (Mylotarg®) for Advanced MDS and Secondary or Relapsed AML.
Authors: Amelia A. Langston, Stephanie McMillan, Sagar Lonial, Kenneth Smith, Edmund K. Waller, Leonard T. Heffner, Silvana Bucur, Istvan Redei, Christopher Flowers, Mary J. Lechowicz, Elliot Winton
Journal: Blood (2004)
What does PD-L1 positive or negative mean?
Authors: Antoni Ribas, Siwen Hu-Lieskovan
Journal: The Journal of Experimental Medicine (2016)

Expression of the programmed death-1 (PD-1) ligand 1 (PD-L1) is used to select patients and analyze responses to anti–PD-1/L1 antibodies. The expression of PD-L1 is regulated in different ways, which leads to a different significance of its presence or absence. PD-L1 positivity may be a result of genetic events leading to constitutive PD-L1 expression on cancer cells or inducible PD-L1 expression on cancer cells and noncancer cells in response to a T cell infiltrate. A tumor may be PD-L1 negative because it has no T cell infiltrate, which may be reversed with an immune response. Finally, a tumor that is unable to express PD-L1 because of a genetic event will always be negative for PD-L1 on cancer cells.
Evaluation of An Automatic Washing Method for DMSO Cryopreserved Peripheral Blood Hematopoietic Progenitors Using the Sepax S-100.
Authors: Miguel Blanquer, Valentín Cabañas-Perianes, Maria Juliana Majado, Victoria Sánchez Ibáñez, Pilar Menchón Sánchez, Jorge Monserrat, Alfonso Morales Lázaro, Jose Maria Moraleda
Journal: Blood (2009)
An In Vivo Evidence That Murine Very Small Embryonic Like (VSEL) Stem Cells Are Mobilized into Peripheral Blood after Acute Myocardial Infarction (AMI) and Contribute to Myocardiac Regeneration.
Authors: Ewa K. Zuba-Surma, Magda Kucia, Yiru Guo, Buddhadeb Dawn, Roberto Bolli, Mariusz Z. Ratajczak
Journal: Blood (2007)
Outcome Measurement in Value-Based Payments
Authors: Samyukta Mullangi, Stephen Schleicher, Thomas W. Feeley
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Cell Adhesion and Migration Regulated by EphB6 Expressed on Human Hematopoietic Progenitors.
Authors: Toshimitsu Matsui, Hiroshi Matsuoka, Akira Tamekane, Ryuichi Inoue, Manabu Shimoyama, Atsushi Okamura, Hiroya Obama, Meghan L. Kelly, Masaru Nakamoto
Journal: Blood (2005)
Time to Treatment Failure (TTF) and FLIPI Correlate Well with Survival and Are Independent Variables in Stage IV Indolent Follicular Lymphomas (IFL).
Authors: Luis Fayad, Barbara Pro, Qi Liu, Mark Hess, Fredrick Hagemeister, Jorge Romaguera, Felipe Samaniego, Fernando Cabanillas, Alma Rodriguez, Anas Younes, Michael Wang, Peter McLaughlin
Journal: Blood (2005)
Commentary on “Apoptosis, p53, and Tumor Cell Sensitivity to Anticancer Agents”
Authors: Elsa R. Flores
Journal: Cancer Research (2016)

Visit the Cancer Research 75th Anniversary [timeline][1].

See related article by Brown and Wouters, [Cancer Res 1999;59:1391–9][2] .

In 1999, a review on apoptosis, p53, and tumor cell sensitivity to anticancer agents was published in Cancer Research ([1][3]). TP53 is one of the most commonly
Identifying Chemical Groups for Biomonitoring
Authors: Gail Krowech, Sara Hoover, Laurel Plummer, Martha Sandy, Lauren Zeise, Gina Solomon
Journal: Environmental Health Perspectives (2016)

Summary:Regulatory agencies face daunting challenges identifying emerging chemical hazards because of the large number of chemicals in commerce and limited data on exposure and toxicology. Evaluating one chemical at a time is inefficient and can lead to replacement with uncharacterized chemicals or chemicals with structural features already linked to toxicity. The Office of Environmental Health Hazard Assessment (OEHHA) has developed a process for constructing and assessing chemical groups for potential biomonitoring in California. We screen for chemicals with significant exposure potential and propose possible chemical groups, based on structure and function. To support formal consideration of these groups by Biomonitoring California’s Scientific Guidance Panel, we conduct a detailed review of exposure and toxicity data and examine the likelihood of detection in biological samples. To date, 12 chemical groups have been constructed and added to the pool of chemicals that can be selected for Biomonitoring California studies, including p,p´-bisphenols, brominated and chlorinated organic compounds used as flame retardants, non-halogenated aromatic phosphates, and synthetic polycyclic musks. Evaluating chemical groups, rather than individual chemicals, is an efficient way to respond to shifts in chemical use and the emergence of new chemicals. This strategy can enable earlier identification of important chemicals for monitoring and intervention.
Incidence and Mortality of Second Malignancies In 559 Patients with Chronic Myeloid Leukemia (CML) Treated with Imatinib Frontline: Data From the GIMEMA CML Working Party
Authors: Gabriele Gugliotta, Fausto Castagnetti, Francesca Palandri, Massimo Breccia, Francesco Cavazzini, Roberto Di Lorenzo, Luciano Levato, Mariella Girasoli, Giuseppe Leone, Elisabetta Abruzzese, Mario Tiribelli, Vittorio Meneghini, Piero Galieni, Elena Trabacchi, Giuliana Alimena, Giovanni Martinelli, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, Gianantonio Rosti
Journal: Blood (2010)
Reduced-Intenisty Unrelated Cord Blood Transplantation for Patients with Advanced Malignant Lymphoma.
Authors: Naoyuki Uchida, Shigesaburo Miyakoshi, Tomoko Matsumura, Koichiro Yuji, Shinsuke Takagi, Daisuke Kato, Tomomi Kawano, Eiji Kusumi, Kazuhiro Masuoka, Atsushi Wake, Shuichi Taniguchi
Journal: Blood (2005)
Poor Graft Function Following Allogeneic Stem Cell Transplantation: High Rate of Complete Recovery Using Boost CD34+ Selected Peripheral Blood Stem Cells without Further Conditioning.
Authors: Alessandra Larocca, Barbara Bruno, Carmen Di Grazia, Francesca Gualandi, Domenico Occhini, Anna Maria Raiola, Alida Dominietto, Stefania Bregante, Teresa Lamparelli, Maria Teresa Van Lint, Enrico Maria Pogliani, Andrea Bacigalupo
Journal: Blood (2005)
Proteomic-based research strategy identified laminin subunit alpha 2 as a potential urinary-specific biomarker for the medullary sponge kidney disease
Authors: Antonia Fabris, Maurizio Bruschi, Laura Santucci, Giovanni Candiano, Simona Granata, Alessandra Dalla Gassa, Nadia Antonucci, Andrea Petretto, Gian Marco Ghiggeri, Giovanni Gambaro, Antonio Lupo, Gianluigi Zaza
Journal: Kidney International (2016)
Integrative Genomic Analysis of HIV-Specific CD8+ T Cells Reveals That PD-1 Inhibits T Cell Function by Upregulating the AP-1 Transcription Factor BATF.
Authors: Michael Quigley, Florencia Pereyra, Bjorn Nilsson, Quentin Eichbaum, Boris Julg, Jonathan Jesneck, Kathleen Brosnahan, Kate Russell, Ildiko Toth, Alicja Piechocka-Trocha, Haina Shin, Gordon J Freeman, E. John Wherry, Bruce D Walker, Benjamin L. Ebert, W. Nicholas Haining
Journal: Blood (2009)
A Phase II Trial of Autologous Stem Cell Transplant (AHSCT) Followed by Mini-Allogeneic Stem Cell Transplant (AlloTx) for the Treatment of Multiple Myeloma: Analysis of ECOG E4A98.
Authors: David H. Vesole, Lijun Zhang, Neal Flomenberg, Philip R. Greipp, Hillard M. Lazarus
Journal: Blood (2007)
Long-Term Follow-Up of Patients Treated in a Phase 2 Trial with MyVax® Personalized Immunotherapy (Recombinant Id-KLH with GM-CSF) after Chemotherapy as Initial Treatment for Follicular Non-Hodgkin’s Lymphoma (NHL).
Authors: John M. Timmerman, Julie Vose, Ronald Levy, Martha Mayo, Dan Denney
Journal: Blood (2005)
The Myeloma Cells Escape from Bone Marrow to Skin Extramedullary Localization upon Bortezomib Resistance: Role of CXCR4
Authors: Valentina Marchica, Fabrizio Accardi, Paola Storti, Cristina Mancini, Eugenia Martella, Marina Bolzoni, Katia Todoerti, Chiara Schifano, Sabrina Bonomini, Benedetta Dalla Palma, Magda Marcatti, Maurilio Ponzoni, Antonino Neri, Franco Aversa, Nicola Giuliani
Journal: Blood (2015)
RT-DeVIC Therapy Is Effective for Localized NK/T Cell Lymphoma Patiens
Authors: Kyoko Ueda, Noriko Nishimura, Yuko Mishima, Hideaki Nitta, Yoshiharu Kusano, Masahiro Yokoyama, Naoko Tsuyama, Yasuhito Terui, Kengo Takeuchi, Oguchi Masahiko, Kiyohiko Hatake
Journal: Blood (2014)
BCL11AXL Protein: Its Distribution in Normal and Malignant Tissues and Use as a Marker for Plasmacytoid Dendritic Cells.
Authors: Karen Pulford, Alison H. Banham, Linden Lyne, Margaret Jones, Greg Ippolito, Hiu Liu, Phil W. Tucker, Giovanna Roncador, Elena Lucas, Sally Ashe, Elizabeth Stockwin, Renata Walewska, Elisabeth L. Karran, Randy Gascoyne, David Y. Mason, Martin J.S. Dyer
Journal: Blood (2005)
Mycophenolate Mofetil Vs. Methotrexate for the Prophylaxis of Graft-Versus-Host-Disease - Systematic Review and Meta-Analysis of All Comparative Trials
Authors: Ron Ram, Moshe Yeshurun, Liat Vidal, Ofer Shpilberg, Anat Gafter-Gvili
Journal: Blood (2012)
Pharmacokinetics and Pharmacodynamics of Three Asparaginases in Pediatric Patients with Higher Risk Acute Lymphoblastic Leukemia: A Report from CCG-1961.
Authors: Eduard H. Panosyan, Nita L. Seibel, Rita S. Grigoryan, Ioannis A. Avramis, Jon D. Jaques, Lawrence J. Ettinger, Paul S. Gaynon, Harland N. Sather, Janet Franklin, Fu Cecilia, Stuart E. Siegel, Howard J. Fingert, Vassilios I. Avramis
Journal: Blood (2004)
Comparison between 2-Deoxy-2-[18f]Fluoro-D-Glucose Positron Emission (FDG-PET) and Computed Tomography (CT) for Staging of Patients with Hodgkin’s Lymphoma (HL).
Authors: Luigi Rigacci, Francesco Merli, Antonio Castagnoli, Annibale Versari, Luca Nassi, Ida Capodanno, Teodoro Chisesi, Andrea Gallamini, Alberto Biggi, Umberto Vitolo, Silvia Tavera, Rosaria Sancetta, Patrizia Pregno, Francesca Salvi, Ettore Pelosi, Alessandro Levis, Alberto Bosi
Journal: Blood (2005)
Ofatumumab (OFA) in Combination with CHOP for Previously Untreated Follicular Lymphoma: Follow-up Results
Authors: Myron S. Czuczman, Georg Hess, Ole Gadeberg, Lars Moeller Pedersen, Per Hansen, David Belada, Stephanie A. Gregory, Brad Pohlman, Jiri Mayer, Robert Pytlik, Lorenz Trumper, Andreas Viardot, Ira V. Gupta, Thomas S. Lin, Paul Winter, Nancy Goldstein, Roxanne C. Jewell, Steen Lisby
Journal: Blood (2012)
Fatal Nonbacterial Pneumonia Associated With Adenovirus Type 4
Authors: Cpt Stuart Levin, Cpt John Dietrich, Cpt Joseph Guillory
Journal: JAMA (1967)

Fatal nonbacterial pneumonia occurred in a previously healthy young adult. Epidemiological, virological, and pathological studies suggest an etiological relationship between adenovirus type 4 isolation and this fatal pneumonia. This is the first such relationship in a previously healthy adult which has been reported to our knowledge. ADENOVIRUS, one of the four major groups of deoxyribonucleic acid animal viruses, is composed of at least 45 distinct serotypes. Adenovirus isola¬ tions have been associated with respiratory disease, epidemic keratoconjunctivitis, meningitis and en¬ cephalitis, a pertussis-like syndrome, intussuscep¬ tion, and a rubella-like illness. An adenovirus has been an etiologic apent in occasional cases of thyroiditis.2 Oncogenous effects have been described secondary to laboratory-acquired adenovirus infec¬ tions in newborn hamsters. Fatal hepatic necrosis has also been recently reported in association with an adenovirus isolation.' Adenovirus type 4 is a major cause of acute respiratory disease in military recruits, but has been recognized as producing only sporadic disease in the civilian population.' Fatalities from adenovirus respiratory disease have been reported only in infants, many of whom were debilitated from preceding illnesses. To our knowledge, no reported fatality has occurred in a previously healthy adult.
Stroma-Induced TCL1 Expression In Chronic Lymphocytic Leukemia Cells Is Associated with Down Regulation of TCL1A-Targeting miRNAs
Authors: Mariela Sivina, Elena Hartmann, Jorge Boucas, Michael J Keating, William G. Wierda, Marco Herling, Andreas Rosenwald, Jan A. Burger
Journal: Blood (2010)