tbuckley/cabot-search huggingface dataset:
Comparison of 111In-[DTPA0]Octreotide Versus Non Carrier Added 177Lu- [DOTA0,Tyr3]-Octreotate Efficacy in Patients With GEP-NET Treated Intra-arterially for Liver Metastases
Authors: G. S. Limouris, V. Poulantzas, N. Trompoukis, I. Karfis, S. Chondrogiannis, N. Triantafyllou, V. Gennimata, L.-E. Moulopoulou, E. Patsouris, G. Nikou, V. Michalaki, G. Fragulidis, M. Paphiti, R. V. McCready, P. M. Colletti, G. J. Cook, D. Rubello
Journal: Clinical Nuclear Medicine (2015)

In patients with progressive, metastatic neuroendocrine tumors (NET), intra-arterial radionuclide infusions with high activities of In-[DTPA]-octreotide and more recently with non-carrier added (nca) Lu-[DOTA,Tyr]-octreotate have been performed with encouraging results. However, the affinity profiles (IC50) of these radiopeptides for human sst2 receptors are markedly different (In-[DTPA]-octreotide, 22 ± 3.6 nM and nca Lu-[DOTA,Tyr]-octreotate, 1.5 ± 4.0 nM). The total administered activity is determined by organ dose limits (kidneys and bone marrow), and our aim therefore was to compare and evaluate the therapeutic efficacy of both radiopeptides in metastatic NETs.
Do European doctors support measles, mumps, rubella vaccination programmes enough?
Authors: P L Lopalco, M Sprenger
Journal: Eurosurveillance (2011)

Preview this article: Do European doctors support measles, mumps, rubella vaccination programmes enough?, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/39/art19979-en-1.gif
PTU-279 Hyperglycemia increases surgical site infections following colorectal resections for malignancy in a standardised patient cohort
Authors: NM Saur, S Chadi, D Bekele, H Amer, EG Weiss, G Dasilva, SD Wexner
Journal: Gut (2015)

<h3>Introduction</h3> Hyperglycemia causes increased postoperative morbidity and mortality. Heterogeneous patient populations and differing definitions of hyperglycemia complicate broad applicability of past studies. We examined the effect of hyperglycemia on postoperative infections in patients with colorectal cancer resections. <h3>Method</h3> A retrospective review of an IRB-approved prospectively maintained database was performed for all patients with a colorectal resection and anastomosis for malignancy at a single centre from 2008–2014. All analyses, confounding variables and outcomes were proposed <i>a priori</i>. Primary outcome was evidence of a surgical site infection (SSI) defined by the Centres for Disease Control criteria and analysed as a cumulative variable of superficial, deep and organ space infections. Main independent variable was post-operative day 1 (POD1) glucose level with hyperglycemia defined <i>a priori</i>as &gt;180 mg/dL. Univariate analyses were performed using a Chi-squared test for categorical variables. Multivariable logistic regression was performed to adjust for confounding and identify the role of proposed variables on predicting the outcome of SSI. <h3>Results</h3> 349 patients underwent colorectal resections for malignancy (mean age: 65.3 (+/-13.7) years). All patients received preoperative antibiotics. 20% had a stage 3 or 4 malignancy. 26 patients had POD1 hyperglycemia (mean 128.6 mg/dL +/- 33.6) with 70 (20%) identified with a SSI. Mean operative time was 190 ± 111 min. On univariate analysis, POD1 glucose (p = 0.312) nor POD1 hyperglycemia (p = 0.054) as continuous variables were not associated with the presence of SSI (p = 0.312). Active smokers and those who had an open resection had higher rates of SSI (p = 0.015, p &lt; 0.001, respectively). A higher cancer stage (3 or 4) was significantly associated with SSI (p = 0.03). Multivariate logistic regression adjusting for known predictors (smoking status, surgical approach, diagnosis of diabetes, cancer stage and POD1 hyperglycemia) was performed with the dependent variable evidence of SSI (Hosmer-Lemeshow p = 0.45); operative time was excluded for concerns of co-linearity with surgical technique. Smoking (OR 4.6, 1.8–11.7; p = 0.002) and hyperglycemia (3.3, 1.2–9.1; p = 0.019) significant predictors of SSI while laparoscopy (n = 209; 60%) was protective against SSI (OR 0.21, 0.12–0.39; p &lt; 0.001). <h3>Conclusion</h3> Our study demonstrates that POD1 hyperglycemia is associated with increased rates of SSI when controlling for confounders. This reiterates the need for stringent postoperative glycemic control regardless of history of diabetes to further improve surgical outcomes. <h3>Disclosure of interest</h3> None Declared.
Book: An Intelligent Person's Guide to Genetics
Authors: Fred Kavalier
Journal: BMJ (2005)

Always a sucker for a quick fix, I was immediately attracted to Adrian Woolfson's book by its title. An Intelligent Person's Guide to Genetics promises something to the potential reader: “If you are an intelligent person,” it says, “I will explain genetics to you in a way that you will understand.” Perhaps now, I thought, it would all become a little clearer.​clearer.




Figure 1



Adrian Woolfson

Duckworth Overlook, £12.99/$21.95, pp 240 ISBN 0 7156 3313 9

Rating: ★★★




Only one thing about genetics is utterly clear to me: it's much more complicated than I ever imagined. When I was learning about genetics in school it seemed relatively straightforward. Gregor Mendel had his peas. Some things were dominant, some were recessive. DNA was made from four simple nucleotide molecules (C, T, A, and G), which were arranged in a double helix shape. The strands of DNA were capable of copying themselves. The DNA was parcelled up into chromosomes. Strung along the chromosomes, like beads on a string, were the genes, surrounded by lots of so called “junk” DNA. The junk was the detritus of evolution. It did no good, but evolutionary forces had allowed it to remain in the genome because it did no harm. The genes—the gold dust of the genome—coded for proteins. The mantra was simple: DNA makes RNA, which makes protein.

Fifty years down the line, most of this is still true. But there is so much more going on within and all around the genome. We now know (or at least think we know) that human beings have only about 25 000 genes, many fewer than predicted. DNA still makes RNA, which still makes protein. But one string of DNA can make many proteins, so you have to be much more careful when you recite the mantra in public. There are epigenetic factors, such as imprinting and methylation. There are pseudogenes and promoters and retrotransposons. Genes get turned on and turned off and turned up and turned down. Two identical twins with identical mutations in their BRCA1 gene won't necessarily both get breast cancer. We don't even really understand why I am not a chimpanzee.

Adrian Woolfson takes us through all this, and much more, in a 240 page whirlwind exposition of evolution, the history of molecular biology, molecular genetics, and the future. It is not “an intelligent person's guide to genetics,” because the subject is too big and the book too small. Despite the many enigmas that he uncovers, Woolfson seems to have an abiding faith that one day we will not only understand it all but be able to build it from scratch. To many this will seem a tall order. But Woolfson sees “synthetic life” as inevitable, “because we are intrinsically curious, [and] because we have utopian desires.”
Case 35-1969
Authors: Arnold N. Weinberg, Robert E. Scully, Walter G. Bradley
Journal: New England Journal of Medicine (1969)

Presentation of CaseA fifty-six-year-old woman was admitted to the hospital because of difficulty with speech.She had been well until five days previously, when she became febrile, with a temperature of 102°F, muscular aches and a headache. She took aspirin and stayed in bed. She had a cough productive of scanty amounts of mucoid sputum, but no pleuritic pain or chills. Two days before entry calluses were trimmed from her feet. Early on the morning of admission her son found her unable to speak clearly but able to move all the extremities.There was no history of rheumatic fever, . . .
Increased incidence of Mycoplasma pneumoniae infections detected by laboratory-based surveillance in Denmark in 2010
Authors: J N Rasmussen, M Voldstedlund, R L Andersen, S Ellermann-Eriksen, T G Jensen, H K Johansen, B Kolmos, M Mølvadgaard, S  S Nielsen, E Olsen, K Schønning, S  A Uldum
Journal: Eurosurveillance (2010)

In Denmark recurrent epidemics of Mycoplasma pneumoniae infections have been described since the 1950s at intervals of approximately four to six years. The latest epidemic occurred in 2004/05 followed by two years of high incidence and more than three years of low incidence. Due to a recent increase in diagnosed cases since late summer 2010, we conducted a survey of positive M. pneumoniae PCR tests performed by clinical microbiology departments in Denmark, which indicated that a new epidemic may be underway.
Treatment of Lupus Nephritis With Abatacept: The Abatacept and Cyclophosphamide Combination Efficacy and Safety Study
Journal: Arthritis & Rheumatology (2014)

Objective To assess the efficacy and safety of a 24‐week course of abatacept in the treatment of active lupus nephritis and to assess the potential of abatacept to induce “clinical tolerance,” defined as sustained clinical quiescence of lupus nephritis after discontinuation of immunosuppressive therapy. Methods Patients with active lupus nephritis (n = 134) were enrolled in a randomized, double‐blind phase II add‐on trial in which they received either abatacept or placebo in conjunction with the Euro‐Lupus Nephritis Trial regimen of low‐dose cyclophosphamide (CYC) followed by azathioprine (AZA). The primary efficacy outcome was the frequency of complete response at week 24. Thereafter, patients who met either complete or partial response criteria continued blinded treatment through week 52. During this phase of the study, subjects in the abatacept treatment group in whom a complete response was achieved at week 24 discontinued immunosuppressive therapy other than prednisone (10 mg/day). Results There were no statistically significant differences between groups with respect to the primary outcome or any of the secondary outcomes, including measures of safety. A complete response was achieved in 33% of the subjects in the treatment group and in 31% of the subjects in the control group at week 24. Fifty percent of the subjects in the treatment group who met complete response criteria and therefore discontinued immunosuppressive therapy at week 24 maintained their complete response status through week 52. Conclusion The addition of abatacept to a regimen of CYC followed by AZA did not improve the outcome of lupus nephritis at either 24 or 52 weeks. No worrisome safety signals were encountered.
ELECTRICAL PACEMAKERS AND VENTRICULAR ARRHYTHMIAS
Authors: M L JANOWER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 12-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Gwilym S. Lodwick, Andrew E. Rosenberg
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 28-year-old woman was admitted to the hospital because of lesions of the sacrum and ilium.She was well until three years earlier, when pain and numbness developed in the posterolateral left thigh and leg during the fifth month of her second pregnancy. The pain gradually worsened over the next three years and spread to involve the lumbosacral region and both buttocks. X-ray films of the lower spine and pelvis (Fig. 1) showed a well-demarcated osteosclerotic lesion in the left sacral wing and a second lesion in the body of the sacrum that appeared to be osteolytic . . .
Cancer and Other Tumors of the Stomach.
Journal: JAMA (1903)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bovine Ocular Squamous-Cell Carcinoma. IV. Tissue-Culture Studies of Bovine Ocular Squamous-Cell Carcinoma and Its Benign Precursor Lesions&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;4&lt;/xref&gt;
Authors: Sykes, John A., Dmochowski, Leon, Wynne, E. Staten, Russell, W. O.
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Bovine Ocular Squamous-Cell Carcinoma. IV. Tissue-Culture Studies of Bovine Ocular Squamous-Cell Carcinoma and Its Benign Precursor Lesions Get access John A. Sykes, John A. Sykes Section of Virology and Electron Microscopy and Department of Pathology, University of Texas M. D. Anderson Hospital and Tumor Institute, and Department of Microbiology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar Leon Dmochowski, Leon Dmochowski Section of Virology and Electron Microscopy and Department of Pathology, University of Texas M. D. Anderson Hospital and Tumor Institute, and Department of Microbiology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Staten Wynne, E. Staten Wynne Section of Virology and Electron Microscopy and Department of Pathology, University of Texas M. D. Anderson Hospital and Tumor Institute, and Department of Microbiology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar W. O. Russell W. O. Russell Section of Virology and Electron Microscopy and Department of Pathology, University of Texas M. D. Anderson Hospital and Tumor Institute, and Department of Microbiology, Baylor University College of Medicine, Texas Medical Center, Houston, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 26, Issue 2, February 1961, Pages 445–471, https://doi.org/10.1093/jnci/26.2.445 Published: 01 February 1961 Article history Received: 15 August 1960 Published: 01 February 1961
Lorazepam, a new benzodiazepine derivative, in the treatment of anxiety: a double-blind clinical evaluation
Authors: L McCurdy
Journal: American Journal of Psychiatry (1979)

Ninety-five adult outpatients suffering from moderate to severe anxiety were randomly assigned to treatment with lorazepam or placebo in a double-blind four-week study. Patients were evaluated at pretreatment and after two and four weeks of treatment using three rating scales. Lorazepam, at an average daily dose of 3.2 mg twice daily, was highly effective in relieving anxiety as documented by clinically and statistically significant differences over placebo in most of the items on all rating scales at all rating periods. No serious adverse effects were reported, and there were no adverse interactions with other medications, including digitalis and aspirin.
SP0208 Human Central and Peripheral B-Cell Tolerance Checkpoints: Intrinsic and Extrinsic Regulation
Authors: E. Meffre
Journal: Annals of the Rheumatic Diseases (2015)

Patients with primary immunodeficiencies provide rare opportunities to study the impact of specific defective genes on the regulation of B-cell tolerance and the removal of developing autoreactive B cells in humans. In addition, impaired immune functions leading to primary immunodeficiencies often correlate with paradoxical autoimmune complications. Alterations in B cell receptor (BCR) signaling pathways in patients lacking functional BTK, CD19, or molecules mediating TLR signaling such as IRAK4, MyD88, ADA and TACI result in a defective central checkpoint and a failure to counterselect developing autoreactive B cells. Indeed, the binding of self-antigens to autoreactive BCRs and TLRs fail to induce tolerance mechanisms due to increase receptor signaling thresholds in all these patients9 B cells and autoreactive B cells leaks from the bone marrow into the periphery. Our investigations revealed that central B-cell tolerance defects are primary to many autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and type 1 diabetes (T1D) and result from genetic factors segregating with autoimmunity and which encode variants such as the C1858T PTPN22 risk allele. However, we found that patients with multiple sclerosis (MS) only displayed peripheral B-cell tolerance checkpoint defects whereas central B-cell tolerance was often established normally. Similar observations were observed in CD40L-, MHC class II- and DOCK8-deficient patients, who pointed to a potential role for regulatory T (Treg) cells in the removal of developing autoreactive B cells in the periphery. Specific peripheral B-cell tolerance checkpoint defects were also identified in IPEX patients carrying a FOXP3 mutation, which prevents the generation of functional Tregs. Interestingly, Treg cell functions have been reported to be defective in MS patients as well as in patients with RA. Hence, Tregs may play an essential role in preventing the accumulation of autoreactive B cells in subject9s blood, thereby controlling the establishment and the maintenance of B-cell tolerance in the periphery. <h3>Disclosure of Interest</h3> None declared
Effects of Dietary Protein and Carbohydrate Level on Cholesterolemia and Atherogenesis in Cockerels on a High-Fat, High-Cholesterol Mash
Authors: YALE J. KATZ
Journal: Circulation Research (1958)

Renal lymphatic pressure was found to be increased either by partial occlusion of the renal vein or total occlusion of the ureter. Simultaneous measurement of interstitial and lymphatic pressure revealed that with compression of the renal vein the rise in interstitial pressure preceded the rise in lymphatic pressure.
Therapy of primary systemic CD30-positive anaplastic large-cell lymphoma of the adult.
Authors: R Fanin, F Silvestri
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.11.3049 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8918504 Therapy of primary systemic CD30-positive anaplastic large-cell lymphoma of the adult. R FaninxR FaninSearch for articles by this author , F SilvestrixF SilvestriSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.11.3049 PDF "Therapy of primary systemic CD30-positive anaplastic large-cell lymphoma of the adult.." Journal of Clinical Oncology, 14(11), pp. 3049–3050© 1996 by American Society of Clinical Oncology
AB0612 Clinical Outcomes of Hydronephrosis in Patients with Systemic Lupus Erythematosus
Authors: S. Hong, Y.-G. Kim, S.M. Ahn, S.-H. Bae, D.-H. Lim, C.-K. Lee, B. Yoo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hydronephrosis is a rare complication of systemic lupus erythematosus (SLE). Bladder and/or gastrointestinal involvement in SLE are associated with development of hydronephrosis, but the management and treatment outcomes of hydronephrosis are largely unknown. <h3>Objectives</h3> We investigated the clinical manifestations and factors associated with the treatment response in patients with SLE complicated by hydronephrosis. <h3>Methods</h3> A retrospective analysis was performed of all 634 SLE patients who underwent computed tomography and/or ultrasonography between January 1998 and December 2013. We reviewed the clinical characteristics and treatment outcomes of patients with SLE-associated hydronephrosis. <h3>Results</h3> Hydronephrosis was identified in 15 patients with SLE complicated by cystitis and/or enteritis. All patients were treated initially with moderate to high dose corticosteroids. A follow-up imaging study showed that 11 (73.3%) of 15 patients experienced improvements in hydronephrosis, and urinary obstruction was resolved without urological intervention in the majority of these patients (8/11, 72.7%). The four patients who experienced no improvement in hydronephrosis were older than those who responded to treatment (median age (IQR); 43.0 (37.5-53.0) years vs. 28.0 (21.0-38.5) years; p=0.026). In addition, delayed treatment (≥1 month after onset of symptoms) with corticosteroids was more frequently observed in the non-responding patients than in the responding patients (p=0.011). <h3>Conclusions</h3> Our findings suggest that treatment with corticosteroids alone leads to favorable outcomes in patients with SLE-associated hydronephrosis, except when treatment is delayed, particularly in elderly patients. <h3>Disclosure of Interest</h3> None declared
Planning for a mental hospital phasedown
Authors: M P Lawton, M B Lipton, M C Fulcomer, M H Kleban
Journal: American Journal of Psychiatry (1977)

The authors studied the patients and community facilities in an area for which a mental hospital phasedown was contemplated. They found that patients who were continuously hospitalized during a 9-month period were highly dependent and judged unlikely to be candidates for community placement. By contrast, the patients who had been discharged during this 9-month period were judged relocatable by staff and constituted a select group in terms of independence. The authors' survey of community facilities indicated few placement possibilities for the majority of the continuously hospitalized patients.