tbuckley/cabot-search huggingface dataset:
Abstract 1133: Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state
Authors: zhiguo li, li jie, Liu xiaoqi
Journal: Cancer Research (2015)

Abstract One outcome of activation of the PI3K pathway is increased aerobic glycolysis, but the upstream signaling events that regulate the PI3K pathway, thus the Warburg effect, are elusive. Increasing evidence suggests that Plk1, a cell cycle regulator, is also involved in cellular events in addition to mitosis. To test whether Plk1 contributes to activation of the PI3K pathway, thus aerobic glycolysis, we have identified PTEN as a Plk1 substrate. We hypothesize that Plk1 phosphorylation of PTEN contributes to activation of the PI3K pathway and the Warburg effect. Our data show that overexpression of Plk1 leads to activation of the PI3K pathway and enhanced aerobic glycolysis. In contrast, inhibition of Plk1 causes markedly reduced glucose metabolism in mice. Mechanistically, we show that Plk1 phosphorylation of PTEN and Nedd4-1 results in PTEN inactivation. Finally, we show that Plk1 phosphorylation of PTEN promotes tumorigenesis in both its phosphatase-dependent and -independent pathways. Note: This abstract was not presented at the meeting. Citation Format: zhiguo li, li jie, Liu xiaoqi. Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1133. doi:10.1158/1538-7445.AM2015-1133
An association of metabolic syndrome and chronic kidney disease from a 10-year prospective cohort study
Authors: Ji Hye Huh, Dhananjay Yadav, Jae Seok Kim, Jung-Woo Son, Eunhee Choi, Seong Hwan Kim, Chol Shin, Ki-Chul Sung, Jang Young Kim
Journal: Metabolism (2016)
<i>TERT</i> Promoter Mutations Enhance Telomerase Activation by Long-Range Chromatin Interactions
Authors: Jaewon Min, Jerry W. Shay
Journal: Cancer Discovery (2016)

Abstract Summary: Although single-nucleotide somatic mutations in the proximal promoter of the human telomerase reverse transcriptase (TERT) gene create novel consensus sequences for transcription factors that enhance TERT expression, the precise mechanism of how telomerase is reactivated in cancer cells remains poorly understood. In this issue, Akıncılar and colleagues identify a potential mechanism of TERT reactivation that is mediated by a novel long-range chromatin interaction between the TERT promoter on chromosome 5p and a 300-kb upstream region. This permits recruitment of the transcription factor GABPA in mutant TERT promoters but not in wild-type promoters. Cancer Discov; 6(11); 1212–4. ©2016 AACR. See related article by Akıncılar and colleagues, p. 1276.
Feasibility of Imatinib Combination Therapies in a Randomized Trial for Chronic Myeloid Leukemia: The German CML-Study IV - Pilot Phase.
Authors: Ute Berger, Andreas Hochhaus, Andreas Reiter, Markus Pfirrmann, Claudia Schoch, Gerhard Ehninger, Thomas Fischer, Alois Gratwohl, Joerg Hasford, Hermann Heimpel, Dieter K. Hossfeld, Hans-J. Kolb, Stefan Krause, Christoph Nerl, Hans Pralle, Andreas Tobler, Rüdiger Hehlmann
Journal: Blood (2004)
Extreme Home Makeover — The Role of Intensive Home Health Care
Authors: Luis Ticona, Kevin A. Schulman
Journal: New England Journal of Medicine (2016)

Interview with Dr. Kevin Schulman on intensive home health care as an alternative to hospitalization. (06:11)Download Intensive home health care services as an alternative to hospitalization are becoming a standard option in many health systems around the world, but despite its promise, this model of care has had limited uptake in the United States.
Bone Marker Directed Dosing of Zoledronic Acid for the Prevention of Skeletal Complications In Patients with Multiple Myeloma: Interim Analysis Results of the Z-MARK Study
Authors: Noopur Raje, Robert Vescio, Charles W. Montgomery, Ramakrishnan Parameswaran, Diep Tran, Ghulam Warsi, Eliza Argonza-Aviles, Solveig G. Ericson, Kenneth C. Anderson
Journal: Blood (2010)
High-Density Lipoprotein Cholesterol and Cause-Specific Mortality in Individuals Without Previous Cardiovascular Conditions
Authors: Dennis T. Ko, David A. Alter, Helen Guo, Maria Koh, Geoffrey Lau, Peter C. Austin, Gillian L. Booth, William Hogg, Cynthia A. Jackevicius, Douglas S. Lee, Harindra C. Wijeysundera, John T. Wilkins, Jack V. Tu
Journal: Journal of the American College of Cardiology (2016)

The prognostic importance of high-density lipoprotein cholesterol (HDL-C) as a specific risk factor for cardiovascular (CV) disease has been challenged by recent clinical trials and genetic studies.This study sought to reappraise the association of HDL-C level with CV and non-CV mortality using a "big data" approach.An observational cohort study was conducted using the CANHEART (Cardiovascular Health in Ambulatory Care Research Team) dataset, which was created by linking together 17 different individual-level data sources. People were included if they were between 40 and 105 years old on January 1, 2008, living in Ontario, Canada, without previous CV conditions or severe comorbidities, and had an outpatient fasting cholesterol measurement in the year prior to the inception date. The primary outcome was cause-specific mortality.A total of 631,762 individuals were included. The mean age of our cohort was 57.2 years, 55.4% were women, and mean HDL-C level was 55.2 mg/dl. There were 17,952 deaths during a mean follow-up of 4.9 ± 0.4 years. The overall all-cause mortality rate was 8.1 per 1,000 person-years for men and 6.6 per 1,000 person-years for women. Individuals with lower HDL-C levels were more likely to have low incomes, unhealthy lifestyle, higher triglycerides levels, other cardiac risk factors, and medical comorbidities. Individuals with lower HDL-C levels were independently associated with higher risk of CV, cancer, and other mortality compared with individuals in the reference ranges of HDL-C levels. In addition, individuals with higher HDL levels (>70 mg/dl in men, >90 mg/dl in women) had increased hazard of non-CV mortality.Complex associations exist between HDL-C levels and sociodemographic, lifestyle, comorbidity factors, and mortality. HDL-C level is unlikely to represent a CV-specific risk factor given similarities in its associations with non-CV outcomes.
Adenovirus serotype 5 vaccine vectors trigger IL-27–dependent inhibitory CD4 <sup>+</sup> T cell responses that impair CD8 <sup>+</sup> T cell function
Authors: Rafael A. Larocca, Nicholas M. Provine, Malika Aid, M. Justin Iampietro, Erica N. Borducchi, Alexander Badamchi-Zadeh, Peter Abbink, David Ng’ang’a, Christine A. Bricault, Eryn Blass, Pablo Penaloza-MacMaster, Kathryn E. Stephenson, Dan H. Barouch
Journal: Science Immunology (2016)

Adenovirus serotype 5 (Ad5) vaccine vectors elicit robust CD8+ T cell responses, but these responses typically exhibit a partially exhausted phenotype. However, the immunologic mechanism by which Ad5 vectors induce dysfunctional CD8+ T cells has not previously been elucidated. Here we demonstrate that, following immunization of B6 mice, Ad5 vectors elicit antigen-specific IL-10+CD4+ T cells with a distinct transcriptional profile in a dose-dependent fashion. In rhesus monkeys, we similarly observed upregulated expression of IL-10 and PD-1 by CD4+ T cells following Ad5 vaccination. These cells markedly suppressed vaccine-elicited CD8+ T cell responses in vivo and IL-10 blockade increased the frequency and functionality of antigen-specific CD8+ T cells as well as improved protective efficacy against challenge with recombinant Listeria monocytogenes. Moreover, induction of these inhibitory IL-10+CD4+ T cells correlated with IL-27 expression and IL-27 blockade substantially improved CD4+ T cell functionality. These data highlight a role for IL-27 in the induction of inhibitory IL-10+CD4+ T cells, which suppress CD8+ T cell magnitude and function following Ad5 vector immunization. A deeper understanding of the cytokine networks and transcriptional profiles induced by vaccine vectors should lead to strategies to improve the immunogenicity and protective efficacy of viral vector-based vaccines.
Mitochondrial DNA (mtDNA) Sequence Heterogeneity among and within Single Human CD34 Cells, T Cells, B Cells and Granulocytes.
Authors: Yoji Ogasawara, Kazutaka Nakayama, Magdalena Tarnowka, J. Philip McCoy, Jeffrey J. Molldrem, Barbara C. Levin, Sachiko Kajigaya, Neal S. Young
Journal: Blood (2004)
Coinhibition of the deubiquitinating enzymes, USP14 and UCHL5, with VLX1570 is lethal to ibrutinib- or bortezomib-resistant Waldenstrom macroglobulinemia tumor cells
Authors: A Paulus, S Akhtar, T R Caulfield, K Samuel, H Yousaf, Y Bashir, S M Paulus, D Tran, R Hudec, D Cogen, J Jiang, B Edenfield, A Novak, S M Ansell, T Witzig, P Martin, M Coleman, V Roy, S Ailawadhi, K Chitta, S Linder, A Chanan-Khan
Journal: Blood Cancer Journal (2016)

Abstract The survival of Waldenstrom macroglobulinemia (WM) tumor cells hinges on aberrant B-cell receptor (BCR) and MYD88 signaling. WM cells upregulate the proteasome function to sustain the BCR-driven growth while maintaining homeostasis. Clinically, two treatment strategies are used to disrupt these complementary yet mutually exclusive WM survival pathways via ibrutinib (targets BTK/MYD88 node) and bortezomib (targets 20 S proteasome). Despite the success of both agents, WM patients eventually become refractory to treatment, highlighting the adaptive plasticity of WM cells and underscoring the need for development of new therapeutics. Here we provide a comprehensive preclinical report on the anti-WM activity of VLX1570, a novel small-molecule inhibitor of the deubiquitinating enzymes (DUBs), ubiquitin-specific protease 14 (USP14) and ubiquitin carboxyl-terminal hydrolase isozyme L5 (UCHL5). Both DUBs reside in the 19 S proteasome cap and their inhibition by VLX1570 results in rapid and tumor-specific apoptosis in bortezomib- or ibrutinib-resistant WM cells. Notably, treatment of WM cells with VLX1570 downregulated BCR-associated elements BTK, MYD88, NFATC, NF-κB and CXCR4, the latter whose dysregulated function is linked to ibrutinib resistance. VLX1570 administered to WM-xenografted mice resulted in decreased tumor burden and prolonged survival ( P =0.0008) compared with vehicle-treated mice. Overall, our report demonstrates significant value in targeting USP14/UCHL5 with VLX1570 in drug-resistant WM and carries a high potential for clinical translation.
The e13a2 BCR-ABL1 Fusion Transcript Is a Candidate Adverse Prognostic Factor In Chronic Myeloid Leukemia Patients Treated Frontline With Imatinib Mesylate
Authors: Fausto Castagnetti, Gabriele Gugliotta, Massimo Breccia, Alessandra Iurlo, Elisabetta Abruzzese, Francesco Albano, Paolo G Vigneri, Francesco Cavazzini, Ester Orlandi, Patrizia Pregno, Mario Annunziata, Piero Galieni, Enrico Montefusco, Carmen Fava, Francesca Palandri, Claudia Venturi, Simona Soverini, Nicoletta Testoni, Giuliana Alimena, Giuseppe Saglio, Fabrizio Pane, Giovanni Martinelli, Michele Cavo, Michele Baccarani, Gianantonio Rosti
Journal: Blood (2013)
Dimension of Residual CT Scan Mass in Hodgkin's Lymphoma (HL) Is a Negative Prognostic Factor in Patients with PET Negative After Chemo+/− Radiotherapy
Authors: Massimo Magagnoli, Katia Marzo, Monica Balzarotti, Marcello Rodari, Rita Mazza, Laura Giordano, Sara Gandolfi, Stefania Bramanti, Antonella Anastasia, Fabio Romano Lutman, Arturo Chiti, Armando Santoro
Journal: Blood (2011)
FDG-Avid Intrathecal Inflammation Following Administration of Intrathecal Methotrexate
Authors: Molly P. Hogan, Joseph Osborne, Gary A. Ulaner
Journal: Clinical Nuclear Medicine (2016)

Intrathecal methotrexate is a standard option for central nervous system-directed therapy in patients with stage III and IV diffuse large B-cell lymphoma. We present a case of a 50-year-old man with stage IV diffuse large B-cell lymphoma with widespread lymphomatous involvement including the central nervous system, who received 7 doses of intrathecal methotrexate via Ommaya catheter. Posttherapy F-FDG-PET/CT imaging demonstrated diffuse, intense intrathecal FDG avidity, without correlative findings on MR spinal imaging. FDG avidity resolved on follow-up. These PET/CT findings are most consistent with methotrexate-induced thecal inflammation, which needs to be distinguished from intrathecal malignancy.
90y-Ibritumomab Tiuxetan Treatment for Relapsed and/or Refractory B-Cell Non- Hodgkin’S Lymphoma. Multi-Institutional Argentinian Study. An Update
Authors: Roberto Cacchione, Jorge Milone, Javier Bordone, Elsa Nucifora, Juan Dupont, Guy Garay, Dardo Riveros, Alfredo Basso, Silvia Rudoy, Gustavo Milone, Luis Palmer, Daniel Argentieri, Alicia Trouboul, Maria Ardaiz, Marcelo Iabstrebner, Gonzalo Pombo, Alicia Diaz, Roberto Tur, Carlos Chiattone, Hugo Krupitzki, Diana Lafalce, Hugo Corradini, Mario Brown Arnold, Carlos Cañellas, Marta Zerga, Antonio Carrasco, Fernando Bezares
Journal: Blood (2008)
Improved dissolution of Kaempferia parviflora extract for oral administration by preparing solid dispersion via solvent evaporation
Authors: Yotsanan Weerapol, Sukannika Tubtimsri, Chaweewan Jansakul, Pornsak Sriamornsak
Journal: Asian Journal of Pharmaceutical Sciences (2016)

Kaempferia parviflora, a plant in the family Zingiberaceae, has been used in Thai traditional medicines for treating hypertension and promoting longevity with good health and well-being. However, its limited aqueous solubility and low dissolution restrict its bioavailability. The aim of the study was therefore to improve the dissolution rate of K. parviflora extracted with dichloromethane (KPD) by solid dispersions. Different water-soluble polymers were applied to improve dissolution of KPD. The solid dispersions in different ratios were prepared by solvent evaporation method. Only hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol-polyethylene glycol grafted copolymer (PVA-co-PEG) could be used to produce homogeneous, powdered solid dispersions. Physical characterization by scanning electron microscopy, hot stage microscopy, differential scanning calorimetry and powder X-ray diffractometry, in comparison with corresponding physical mixtures, showed the changes in solid state during the formation of solid dispersions. Dissolution of a selected marker, 5,7,4'-trimethoxyflavone (TMF), from KPD/HPMC and KPD/PVA-co-PEG solid dispersions was significantly improved, compared with pure KPD. The dissolution enhancement by solid dispersion was influenced by both type and content of polymers. The stability of KPD/HPMC and KPD/PVA-co-PEG solid dispersions was also good after 6-month storage in both long-term and accelerated conditions. These results identified that the KPD/HPMC and KPD/PVA-co-PEG solid dispersions were an effective new approach for pharmaceutical application of K. parviflora.
Cardiac Failure In Juvenile Rats Caused By Continuous Long-Term Exposure To The Tyrosine Kinase Inhibitor Dasatinib Can Be Circumvented By An Intermittent Application Schedule
Authors: Paula Geidel, Josephine Tabea Tauer, Nadine Steinbronn, Roland Jung, Ivo Leuschner, Ruth H. Strasser, Meinolf Suttorp
Journal: Blood (2013)
Abrupt Onset of Refractory Heart Failure Associated With Light-Chain Amyloidosis in Hypertrophic Cardiomyopathy
Authors: Benedetta Tomberli, Francesco Cappelli, Federico Perfetto, Iacopo Olivotto
Journal: JAMA Cardiology (2016)

The natural history of hypertrophic cardiomyopathy (HCM) is complex and may include progressive heart failure and severe left ventricular dysfunction. When disease progression is abrupt, however, other coexisting diseases should be ruled out. This may be difficult in the case of amyloidosis, which classically mimics HCM.We present an example of severe clinical deterioration in a patient with HCM due to superimposed amyloid light-chain amyloidosis. A man in his 70s with a longstanding history of genetically confirmed HCM presented with rapid development of congestive heart failure over 6 months, in sharp contrast to a previously stable, asymptomatic clinical course. He was diagnosed as having the illness in his late 40s after a resuscitated cardiac arrest and regularly followed up on a yearly basis. His most recent electrocardiogram was profoundly changed from previous tracings, with marked and diffuse voltage reduction (QS in V1-V3) and inferolateral T-wave inversion. The echocardiogram showed an abrupt increase in the severity of left ventricular (LV) hypertrophy, with a concentric rather than asymmetric appearance, granular sparkling of the myocardium, biatrial enlargement, thickening of the mitral valve leaflets, and interatrial septum and mild pericardial effusion. Severe LV dysfunction with a restrictive LV filling pattern was evident, which is associated with LV outflow tract obstruction loss and right ventricle systolic impairment. Following hospital admission, multiple myeloma was diagnosed and confirmed by bone marrow biopsy and aspiration. Furthermore, abdominal fat aspiration showed amyloid deposition and confirmed the diagnosis of amyloid light-chain amyloidosis. Electrocardiograms, echocardiographic images, and videos presented in this report describe the abrupt and marked evolution of a sarcomeric to infiltrative cardiomyopathy, leading to an ominous outcome in which the patient died despite specific treatment.While progression to the end-stage phase occurs over several years for patients with HCM and can be detected at relatively early stages, the abrupt onset of congestive heart failure is uncommon and should raise suspicion of other, superimposed cardiac diseases.
Effects of Periconception Cadmium and Mercury Co-Administration to Mice on Indices of Chronic Diseases in Male Offspring at Maturity
Authors: Cagri Camsari, Joseph K. Folger, Devin McGee, Steven J. Bursian, Hongbing Wang, Jason G. Knott, George W. Smith
Journal: Environmental Health Perspectives (2016)

Long-term exposure to the heavy metals cadmium (Cd) and mercury (Hg) is known to increase the risk of chronic diseases. However, to our knowledge, exposure to Cd and Hg beginning at the periconception period has not been studied to date.We examined the effect of Cd and Hg that were co-administered during early development on indices of chronic diseases in adult male mice.Adult female CD1 mice were subcutaneously administered a combination of cadmium chloride (CdCl2) and methylmercury (II) chloride (CH3HgCl) (0, 0.125, 0.5, or 2.0 mg/kg body weight each) 4 days before and 4 days after conception (8 days total). Indices of anxiety-like behavior, glucose homeostasis, endocrine and molecular markers of insulin resistance, and organ weights were examined in adult male offspring.Increased anxiety-like behavior, impaired glucose homeostasis, and higher body weight and abdominal adipose tissue weight were observed in male offspring of treated females compared with controls. Significantly increased serum leptin and insulin concentrations and impaired insulin tolerance in the male offspring of dams treated with 2.0 mg/kg body weight of Cd and Hg suggested insulin resistance. Altered mRNA abundance for genes associated with glucose and lipid homeostasis (GLUT4, IRS1, FASN, ACACA, FATP2, CD36, and G6PC) in liver and abdominal adipose tissues as well as increased IRS1 phosphorylation in liver (Ser 307) provided further evidence of insulin resistance.Results suggest that the co-administration of Cd and Hg to female mice during the early development of their offspring (the periconception period) was associated with anxiety-like behavior, altered glucose metabolism, and insulin resistance in male offspring at adulthood.
Incidence and Prognostic Value of Chromosomal Abnormalities in Elderly Patients with myeloma: The IFM Experience on 1095 Patients
Authors: Hervé Avet-Loiseau, Cyrille Hulin, Loic Campion, Murielle Roussel, Gerald Marit, Denis Caillot, Anne-Marie Stoppa, Brigitte Pegourie, Jean-Gabriel Fuzibet, Carine Chateleix, Bruno Royer, Catherine Traulle, Olivier Decaux, Lotfi Benboubker, Philippe Casassus, Margaret Macro, Claire Mathiot, Brigitte Kolb, Jean-Paul Fermand, Thierry Facon
Journal: Blood (2011)
CSIG-04LIPID METABOLISM REPROGRAMMING IN GLIOBLASTOMA AND SERVING AS PROMISING TARGET
Authors: Deliang Guo, Chunming Cheng, Feng Geng, Peng Ru, Xiaoning Wu, Peng Hu, Xiang Cheng, Balveen Kaur, Arnab Chakravarti, Jeffrey Yunhua Guo
Journal: Neuro-Oncology (2015)
Challenges and Opportunities in Studies of Cognition in the Prodrome to Psychosis
Authors: Abraham Reichenberg, Josephine Mollon
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Large-Scale Production of Autologous CD14+-Monocyte Derived Dendritic Cells Co-Electroporated with Amplified Total Tumour mRNA and Human CD40L mRNA in Patients with B-Cell Chronic Lymphocytic Leukemia.
Authors: Graeme Fraser, Don Healey, Juan Carlos Rodriguez-Lecompte, Kalathil Suresh, Pamela O’Hoski, Irina Tcherepanova, Mark DeBenedette, Charles Nicolette, Jack Gauldie, Ronan Foley
Journal: Blood (2006)
Combinations of the Histone Deacetylase Inhibitor Entinostat (SNDX-275, MS-275) and Imatinib Have Divergent Effects in Imatinib-Sensitive Vs. Imatinib-Resistant p210-BCR/ABL Expressing Cell Lines.
Authors: Rachel E. Rau, Emily McIntyre, Scott H. Kaufmann, Igor Espinoza-Delgado, Judith Karp, Patrick Brown
Journal: Blood (2009)
Physician Peer Comparisons as a Nonfinancial Strategy to Improve the Value of Care
Authors: Amol S. Navathe, Ezekiel J. Emanuel
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal