tbuckley/cabot-search huggingface dataset:
The Sick Patient
Authors: M Therese Southgate
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Estimating Phylogenies from Lacunose Distance Matrices, with Special Reference to DNA Hybridization Data
Authors: FJ Lapointe, JAW Kirsch
Journal: Molecular Biology and Evolution (1995)

Distance methods for producing phylogenies require n* comparisons among y1 taxa to generate a complete matrix. Moreover, techniques for generating distances-such as DNA hybridization-are subject to both systematic and random experimental errors, so that the measurements do not satisfy the mathematical properties of distances. We have explored the possibility of reconstructing trees from incomplete data. In our simulations, we discard one or both of reciprocal pairs from a complete matrix, estimate these values, reconstruct a tree, and compare the topology and branch lengths of the estimated tree with the phylogeny based on complete data. We investigated separately and jointly the effects of rate variation and random and systematic errors, added to a fabricated ultrametric matrix, and then passed on to simulation experiments with several complete DNA hybridization matrices. Our empirical results show that topological and metric recovery is always very good provided no terminal sister taxa lack both reciprocal measurements or extremely short internodes are involved. We then present two applications of the method for estimating phylogenies from incomplete DNA hybridization matrices-the first illustrating reconstruction of a matrix with about 27% of missing cells, and the second suturing two matrices where some data are held in common but 29% are missing from the combined table. Thus, considerable information may be implicit in very sparse matrices, and this circumstance has practical consequences for distance studies when money, material, or time are limited.
Eight years retrospective analysis of the racial differences in hormone receptor status in lobular carcinoma of the breast in a community cancer center.
Authors: Jean Gabriel Bustamante Alvarez, Jessica Stemple, Konstantinos Sdrimas, Nellowe Candelario, Alessandro Bombonati, Supakanya Wongrakpanich, Aristides Telonis
Journal: Journal of Clinical Oncology (2016)

e12069 Background: Estrogen receptor (ER) positivity in breast tumors has a beneficial prognostic profile. However, ER-positive and progesterone receptor (PR) negative tumors have a higher relative risk of mortality, as well as ER-negative/PR-positive and ER-negative/PR-negative tumors. HER 2/neu, when overexpressed, confers aggressive behavior to breast cancers. Ethnic differences between hormone receptor positivity in lobular breast carcinoma have not yet been fully described. Methods: We retrospectively ascertained patients at AEMC between 2003 and 2011 with lobular breast carcinoma by review of medical records. Age of diagnosis according with Her2, ER and PR positivity were evaluated with a student T-test, as well as according to race (African American vs. Non-Hispanic whites). We also assessed differences of hormone receptor positivity (ER/PR) and Her2/Neu between African Americans and Non-Hispanic whites with a Chi square test. Results: 143 cases were included. 84 patients were Non-Hispanic whites with lobular breast carcinoma, of which 4.76 % were Her2/neu-positive, 97.61 % were ER-positive, and 77.38% were PR-positive. From a total of 59 African Americans, 3.38% were Her2-positive, 98.30% ER-positive, and 74.57% PR-positive. No difference was found in the median age of diagnosis (67 years) among ethnic groups p=0.960 (p>0.05) or according to Her2/neu, ER or PR positivity (p=0.684, 0.5 and 0.23, respectively). ER positivity was more prevalent in Non-Hispanic Whites p=0.043 (p < 0.05). Her2/neu showed no difference in prevalence p=0.414. PR positivity was more frequent among the Non-Hispanic white population when compared with African Americans. Conclusions: In this study, lobular carcinoma showed higher prevalence of ER and PR positivity in Non-Hispanic whites. There was no statistical significance regarding Her2/neu positivity or median age of diagnosis between ethnic groups. These findings suggest that Non-Hispanic whites with lobular breast carcinoma have a more favorable hormone receptor profile. Race Number of ER+ tumors Number of HER2/neu+ tumors Number of PR+ tumors Black 58 2 44 White 82 4 65 Total general 140 6 109 p value 0.043 0.414 0.044
Analysis of the t(2;5)(p23;q35) translocation by reverse transcription- polymerase chain reaction in CD30+ anaplastic large-cell lymphomas, in other non-Hodgkin's lymphomas of T-cell phenotype, and in Hodgkin's disease
Authors: A Wellmann, T Otsuki, M Vogelbruch, HM Clark, ES Jaffe, M Raffeld
Journal: Blood (1995)
Meta-ethical pluralism: A cautionary tale about cohesive moral communities
Authors: Jennifer Cole Wright
Journal: Behavioral and Brain Sciences (2015)

Abstract Meta-ethical pluralism gives us additional insight into how moral communities become cohesive and why this can be problematic (even dangerous) – and in this way provides support for the worries raised by the target article. At the same time, it offers several reasons to be concerned about the proposed initiative, the most important of which is that it could seriously backfire.
QOS-58IMPACT OF CRANIAL RADIATION THERAPY ON HIPPOCAMPAL SUBFIELD VOLUMES AND DECLARATIVE MEMORY IN PEDIATRIC BRAIN TUMOR SURVIVORS
Authors: Alexandra Decker, Kamila Szulc, Jovanka Skocic, Cynthia de Medeiros, Lily Riggs, Eric Bouffet, Colleen Dockstader, Suzanne Laughlin, M. Mallar Chakravarty, Donald Mabbott
Journal: Neuro-Oncology (2016)

BACKGROUND: Cranial radiation therapy (CRT) is associated with declarative memory impairment and hippocampal volume loss in pediatric brain tumor survivors (PBTS).Animal studies suggest that this may reflect Overall survival
QOS-08NEUROCOGNITIVE REHABILITATION IN CHILDREN TREATED FOR BRAIN TUMOURS: A PILOT STUDY IN GUSTAVE ROUSSY CANCER CAMPUS
Authors: Audrey Longaud Valès, Clémentine Lopez, Camille Pouchepadass, Anne Laure Domer, Christelle Dufour, Dominique Valteau Couanet
Journal: Neuro-Oncology (2016)
Genetics of Experimentally Induced Erythroblastosis in Chickens
Authors: Nelson F. Waters, B. R. Burmester, W. G. Walter
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Genetics of Experimentally Induced Erythroblastosis in Chickens Get access Nelson F. Waters, Nelson F. Waters Search for other works by this author on: Oxford Academic PubMed Google Scholar B. R. Burmester, B. R. Burmester Search for other works by this author on: Oxford Academic PubMed Google Scholar W. G. Walter W. G. Walter Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 6, June 1958, Pages 1245–1256, https://doi.org/10.1093/jnci/20.6.1245 Published: 01 June 1958 Article history Received: 22 January 1958 Published: 01 June 1958
Influence of Glass and Cellophane Substrates on Proliferation of Strain L Cells in Tissue Culture&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Wilton R. Earle, Virginia J. Evans, Katherine K. Sanford, John E. Shannon, Jr., Helen K. Waltz
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Influence of Glass and Cellophane Substrates on Proliferation of Strain L Cells in Tissue Culture Get access Wilton R. Earle, Wilton R. Earle National Cancer Institute3, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia J. Evans, Virginia J. Evans National Cancer Institute3, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Katherine K. Sanford, Katherine K. Sanford National Cancer Institute3, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar John E. Shannon, Jr., John E. Shannon, Jr. National Cancer Institute3, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Helen K. Waltz Helen K. Waltz National Cancer Institute3, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 3, December 1951, Pages 563–567, https://doi.org/10.1093/jnci/12.3.563 Published: 01 December 1951 Article history Published: 01 December 1951 Received: 30 August 1961
Off-Pump or On-Pump Coronary-Artery Bypass Grafting
Authors: Stuart J Head, A Pieter Kappetein
Journal: New England Journal of Medicine (2012)

Coronary-Artery Bypass GraftingTo the Editor: In the CABG Off or On Pump Revascularization Study (CORONARY) described by Lamy et al. (March 28 issue), 1 the investigators used the approach of an expertise-based, randomized, controlled trial. 2 The qualified surgeons were those with more than 2 years of experience after residency training who had completed more than 100 cases of the specific technique.Lamy and colleagues also emphasized that "trainees were not allowed to be the primary surgeon."But the authors do not specify who harvested saphenous-vein grafts.In many centers, trainees are the primary surgeons for this procedure.Graft harvesting is an important part of the coronaryartery bypass grafting (CABG) operation.One study showed that rates of vein-graft failure were higher among patients with poor-quality grafts, and vein-graft failure was associated with repeat revascularization. 3
An alternative endoscopic treatment for massive gastric bezoars: Ho:YAG laser fragmentation
Authors: Giuseppe Grande, Mauro Manno, Claudio Zulli, Carmelo Barbera, Santi Mangiafico, Nadia Alberghina, Rita Conigliaro
Journal: Endoscopy (2016)

Gastrointestinal (GI) bezoars are aggregates of indigestible material that occur mainly in patients with altered GI anatomy (i. e. bariatric surgery, partial gastrectomy) and/or motility disorders (i. e. gastroparesis, drug-induced delayed gastric emptying). Other risk factors are high fiber intake, psychiatric diseases, and severe constipation [1].
EPN-22RECURRENT PAEDIATRIC EPENDYMOMA: A RETROSPECTIVE REVIEW OF 194 CASES
Authors: Timothy Ritzmann, Hazel Rogers, Lisa Storer, Nicholas Foreman, Antony Michalski, Kim Phipps, Richard Grundy
Journal: Neuro-Oncology (2016)

Ependymoma is the second most common malignant childhood brain tumour and recurs in 50% of cases.Poor outcomes are associated with incomplete resection and age under 3 years at diagnosis, therefore effective, evidencebased therapies are needed.We have undertaken a retrospective review of 194 children, treated between 1960 and 2015 with at least one recurrence, in order to investigate the clinical behaviour of relapse.Children in the cohort had up to
Psychopharmacologic and clinical correlates of attention in chronic schizophrenia
Authors: M E Strauss, M F Lew, J T Coyle, L E Tune
Journal: American Journal of Psychiatry (1985)

Distractibility and reaction time were measured in 25 clinically stable chronic schizophrenic subjects receiving psychotropic medications. Higher serum neuroleptic levels were associated with lessened distractibility. Extrapyramidal side effects and level of symptoms were each related to slow and variable reaction times.
Migraine headaches and depression
Authors: M J Garvey, G D Tollefson, C B Schaffer
Journal: American Journal of Psychiatry (1984)

After taking the lifetime migraine headache histories of 116 patients with major depressive disorder, the authors compared the prevalence of migraine headaches in these depressed patients with the prevalence of migraine reported in four community surveys. There was a trend for the depressed men to experience a higher prevalence of migraine than men in the general population, but the depressed women had a migraine prevalence similar to that of women in the general population. No differences on multiple variables of depressive illness were found between depressed patients with a history of migraine and those with none.
PNR-17HIGH-DOSE CHEMOTHERAPY WITH STEM CELL TRANSPLANT TO DELAY RADIATION IN PEDIATRIC EMBRYONAL BRAIN TUMOR PATIENTS
Authors: David Raleigh, Brian Tomlin, Benedict Del Buono, Erika Roddy, Katherine Sear, Lennox Byer, Erin Felton, Anu Banerjee, Joseph Torkildson, David Samuel, Steve Braunstein, Daphne Haas-Kogan, Biljana Horn, Sabine Mueller
Journal: Neuro-Oncology (2016)
Low-molecular-weight heparin for venous thromboprophylaxis in ambulatory cancer patients: A meta-analysis
Authors: N. M. Kuderer, A. A. Khorana, C. W. Francis, G. H. Lyman, A. Falanga, T. L. Ortel
Journal: Journal of Clinical Oncology (2009)

9537 Background: Patients with cancer have an increased risk of venous thromboembolism (VTE). However, routine VTE prophylaxis is generally not recommended in ambulatory cancer patients. Several randomized controlled trials (RCTs) of low-molecular-weight heparin (LMWH) in ambulatory cancer patients have been reported with inconclusive results. Methods: A systematic review of RCTs of LMWH in ambulatory cancer patients without a VTE diagnosis was conducted. Included trials had to report VTE as primary or secondary outcome. An extensive electronic database search was conducted, including Medline, EMBASE, Cochrane Library along with abstracts from major meetings. Dual-blinded data extraction was performed. Meta-analysis was conducted using Mantel and Haenszel method to estimate relative risk (RR) and absolute risk difference (ARD) ± 95% CI. Primary outcomes in this analysis were all reported VTE and major bleeds. Most trials did not require VTE screening by imaging, precluding a separate analysis of asymptomatic VTE events. Results: Six RCTs were identified with a total of 2,648 patients including 1,525 receiving LMWH and 1,123 controls. No significant heterogeneity was observed across trials. Among patients receiving LMWH, the crude incidence of VTE was 2.95% compared to 5.25% among control patients. LMWH reduced the RR of VTE by 36% compared to controls (RR=0.64 [0.44 - 0.94], P=0.021), and reduced the ARD by 1.8% [0.2% - 3.4%]. Major bleeding events were reported in 1.57% LMWH patients compared to 0.98% in controls. The non-significant RR increase by LMWH for major bleeding was 1.85 [0.923 - 3.68], P=0.081, with an ARD of 0.9% [0.0% - 1.8%]. Results were comparable in the analysis limited to studies with VTE as primary outcome. Conclusions: While patients experienced a 36% relative risk reduction in VTE with LMWH, the absolute risk reduction was small, and concerns remain about the potential increase in major bleeding. Therefore, routine VTE prophylaxis in ambulatory cancer patients cannot be recommended at this time. Additional research is needed to identify cancer outpatients at high risk for VTE, in whom prophylaxis may have a more favorable risk-benefit ratio. [Table: see text]
LG-77BRAIN PLASTICITY IN PEDIATRIC LOW-GRADE GLIOMAS
Authors: Yahya Ghazwani, Zoltan Patay, Zsila S. Sadighi, Santhosh Upadhyaya, Frederick Boop, Amar Gajjar, Ibrahim Qaddoumi
Journal: Neuro-Oncology (2016)

LG-77. BRAIN PLASTICITY IN PEDIATRIC LOW-GRADE GLIOMAS Yahya Ghazwani, Zoltan Patay, Zsila S. Sadighi, Santhosh Upadhyaya, Frederick Boop, Amar Gajjar, and Ibrahim Qaddoumi; St. Jude Children’s Research Hospital, Memphis,TN, USA BACKGROUND: Neural plasticity (NP) is a well-known phenomenon in the brain, especially in the context of long-existing lesions. Young age and immaturity are associated with high NP. Low-grade gliomas (LGGs) are slowgrowing tumors with good prognosis and are therefore an ideal tumor type to study NP. METHODS: We conducted a retrospective review of 5 patients with LGGs and studied clinical, radiologic, and pathological data for switching handedness. RESULTS: The median age of patients at diagnosis was 51 months (range, 23-93 months). Their median time from switching handedness to diagnosis was 1 month (range, 0.75-60 months). All 5 patients had pilocytic astrocytoma, and none of them had a genetic disorder. Tumors were located in theposterior fossa (n 1⁄4 2), left basal ganglia (n 1⁄4 2), and left thalamus (n 1⁄4 1). Twopatientshad paralysis, and three had paresis in the dominant hand. All the patients continued to prefer using the non-dominant hand, even though function of the dominant hand had recovered fully in only 1 patient after rehabilitation. CONCLUSION: Switching handedness is a major form of NP identified in 5 of our patients with same tumor type but interestingly diverse locations. Further studies of NP in LGGs are required to better understand these findings. Functional MRI studies at diagnosis and follow-up can provide further insight on the phenomenon of NP in patients with LGGs. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.77 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
TETANUS CAN BE PREVENTED
Authors: T S BUMBALO, H V MORELEWICZ, D L BERENS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High Incidence of Diabetes Mellitus in 41 Patients with Gonadal Dysgenesis, and Their Close Relatives
Authors: A P FORBES, E ENGEL
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discharge Planning
Authors: Denise M. Goodman, Alison E. Burke, Edward H. Livingston
Journal: JAMA (2013)

Discharge PlanningT he process of discharge planning prepares you to leave the hospital.It should begin soon after you are admitted to the hospital and at least several days before your planned discharge.The January 23/30, 2013, issue of JAMA has several articles on readmissions after discharge from the hospital. BASICS OF DISCHARGE PLANNING• Know where you will go after you are discharged.You may go home or to a nursing facility.• If you go home, you may need visits from a home health care nurse.It may be advisable for a friend or family member to stay with you after you are home.If possible, make these arrangements before you are admitted to the hospital.• You may need special care such as a special diet, shots, or bandage changes.Sometimes nurses come to your home for this, but family or friends may also help with these if possible.• Some new medications may have been started in the hospital.Know their doses, side effects, and the reason you are receiving them.You may need a prescription and to know which pharmacy to go to.You may continue some of your old medications, but the doses may change.Some of your regular medications may not have been given in the hospital and you may need to start taking them again.Your new medications may need insurance preapproval.• You may need durable medical equipment (DME) at home.This includes walkers or supplemental oxygen.Make sure you know how to get DME after you leave the hospital and how insurance pays for it.• Know what activities you can do.Will you be able to bathe or use the stairs?If you cannot drive, plan how you will get to doctors' appointments, pick up your prescriptions, and handle other chores like grocery shopping.• Know which health care professionals you will see after you are discharged.They should receive a full report of your hospital stay.You may need treatments such as physical therapy.Make sure these appointments are made for you, and ensure that the providers of these services get a report summarizing your hospital stay.