tbuckley/cabot-search huggingface dataset:
PWE-388 Is posterior tibial nerve stimulation an effective treatment for faecal incontinence?
Authors: J Nicholson, J Pearson, C Molyneux, K Telford, A Sharma, E Kiff
Journal: Gut (2015)

<h3>Introduction</h3> Posterior tibial nerve stimulation (PTNS) is a new neuromodulation treatment for faecal incontinence (FI). Our aim of this study was to establish if PTNS is effective, and for which subgroups of FI and whether it influences manometry variables. <h3>Method</h3> Prospective observational cohort study in a tertiary pelvic floor unit. Patients received PTNS for 30 mins once a week for 12 weeks. High resolution anal manometry (HRAM), 2-week bowel diary, FI severity score (Vaizey), FI specific QOL questionnaire (MHQ) were recorded before and 2-weeks after treatment. Clinical data and subjective patient reported outcomes (success/fail) were recorded. <h3>Results</h3> 23 patients, 19 (83%) women, median age 62 (31–78). 12 (52%) mixed incontinence, 7 (30%) urge incontinence, 4 (18%) passive incontinence. We found a reduction in the mean number of urgency episodes (19 v 11, p = 0.002), urge FI episodes (6 v 2, p = 0.038) and passive FI episodes (12 v 8, p = 0.154), with an improvement in Vaizey (16.7 v 14.4, p = 0.003) and MHQ (481.9 v 413.1 p = 0.039) scores. All HRAM variables (mmHg) increased; MRP (40 v 46, p = 0.088), MSP (72 v 92, p = 0.009) and ISP (32 v 45, p = 0.031). Increased rectal sensation (mls); onset (42 v 33, p = 0.064), call (80 v 54, p = 0.000) and urge (112 v 82, p = 0.001). Subjective success occurred in 74% (17), 4 of 6 that failed had passive incontinence. Objective success (defined as &gt;50% or &gt;70% improvement in 2 or more of the following; overall FI episodes, urgency episodes, urge FI episodes, passive FI episodes, Vaizey and MHQ scores) was seen in 52% (12) and 39% (9) respectively. 3 of the 4 men did not improve subjectively or objectively. <h3>Conclusion</h3> PTNS subjectively helped 17 of 23 patients, reflected in improved questionnaires and fewer incontinence episodes. They had increased rectal awareness and stronger squeeze pressures which may have given them more warning and the ability to defer defecation. This study suggests that PTNS appears to help women with urge incontinence. <h3>Disclosure of interest</h3> None Declared.
Treatment of Choriocarcinoma and Chorioadenoma Destruens with 6-Mercaptopurine and Surgery: Clinical Report of 93 Cases
Authors: H C SUNG, P C WU, T H HO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
First case of meningococcal meningitis due to Neisseria meningitidis serogroup Z' in Slovenia, December 2010
Authors: A Trop Skaza, T Selic Kurincic, L Beskovnik, M Paragi, V Bozanic
Journal: Eurosurveillance (2011)

We report here on the identification of the first meningococcal meningitis case in Slovenia caused by Neisseria meningitidis serogroup Z’ in December 2010. The 19-year-old patient had not left the country during the incubation period. The patient was hospitalised and given the antibiotic treatment with cefotaxime very early in the course of the disease. The patient did not develop any complications during hospitalisation and was discharged on 5 January 2011.
Effect of high-speed running on hamstring strain injury risk
Authors: Steven Duhig, Anthony J Shield, David Opar, Tim J Gabbett, Cameron Ferguson, Morgan Williams
Journal: British Journal of Sports Medicine (2016)

Background Hamstring strain injuries (HSIs) are common within the Australian Football League (AFL) with most occurring during high-speed running (HSR). Therefore, this study investigated possible relationships between mean session running distances, session ratings of perceived exertion (s-RPE) and HSIs within AFL footballers. Methods Global positioning system (GPS)-derived running distances and s-RPE for all matches and training sessions over two AFL seasons were obtained from one AFL team. All HSIs were documented and each player's running distances and s-RPE were standardised to their 2-yearly session average, then compared between injured and uninjured players in the 4 weeks (weeks −1, −2, −3 and −4) preceding each injury. Results Higher than ‘typical’ (ie, z=0) HSR session means were associated with a greater likelihood of HSI (week −1: OR=6.44, 95% CI=2.99 to 14.41, p&lt;0.001; summed weeks −1 and −2: OR=3.06, 95% CI=2.03 to 4.75, p&lt;0.001; summed weeks −1, −2 and −3: OR=2.22, 95% CI=1.66 to 3.04, p&lt;0.001; and summed weeks −1, −2, −3 and −4: OR=1.96, 95% CI=1.54 to 2.51, p&lt;0.001). However, trivial differences were observed between injured and uninjured groups for standardised s-RPE, total distance travelled and distances covered whilst accelerating and decelerating. Increasing AFL experience was associated with a decreased HSI risk (OR=0.77, 95% CI 0.57 to 0.97, p=0.02). Furthermore, HSR data modelling indicated that reducing mean distances in week −1 may decrease the probability of HSI. Conclusions Exposing players to large and rapid increases in HSR distances above their 2-yearly session average increased the odds of HSI. However, reducing HSR in week −1 may offset HSI risk.
Lack of Immunizing Capacity of Homologous Cells within Diffusion Chambers
Authors: Richmond T. Prehn, Joan M. Main
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Lack of Immunizing Capacity of Homologous Cells within Diffusion Chambers Get access Richmond T. Prehn, Richmond T. Prehn National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Joan M. Main Joan M. Main National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 5, April 1956, Pages 1257–1261, https://doi.org/10.1093/jnci/16.5.1257 Published: 01 April 1956 Article history Received: 26 August 1955 Published: 01 April 1956
FRI0572 Ultrasound Features of Hand Osteoarthritis (OA) Can be Reliably Scored by Use of Reference Atlases: Table 1
Authors: A. Mathiessen, P.S. Robinson, I.K. Haugen, H.B. Hammer
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> A previously proposed scoring system for assessment of ultrasound (US) features of hand osteoarthritis (OA) includes osteophytes (OP), grey scale synovitis (GS) and power Doppler (PD) signals. However, US is by some considered to be an operator-dependent technology with moderate reliability. <h3>Objectives</h3> By use of US atlases as background [1, 2] to examine intra- and inter-reader reliability of US assessments (OP, GS and PD) of still images by sonographers with varying degree of US experience. <h3>Methods</h3> Stored US images of hand OA joints (carpometacarpal 1, metacarpophalangeal 1-5, proximal interphalangeal 1-5 and distal interphalangeal 2-5) with different degrees of OP (n=133), GS (n=103) and PD (n=20) pathologies were selected and randomized by IKH. With digital US atlases available, three physicians (one inexperienced (PSR), one moderate experienced (AM) and one highly experienced (HBH)) separately scored the anonymised images twice with at least one week interval. All US features were scored on semi-quantitative 0-3 scales. Intra- and inter-reader reliability was assessed by use of kappa (κ; data not shown), weighted kappa (κ<sup>w</sup>), percentage exact agreement (PEA) and percentage close agreement (PCA; scores within ±1 interval). Scores above 0.60 are considered good and scores above 0.80 are very good. <h3>Results</h3> The table provides results from the reliability exercise. With use of US atlas, intra-reader reliability was excellent for OP (κ<sup>w</sup> 0.93–0.95, PEA 100%), GS (κ<sup>w</sup> 0.86–0.91, PEA 83,5%–100%) and PD (κ<sup>w</sup> 0.95–1.00, PEA 100%). The inter-reader reliability was very good for OP (κ<sup>w</sup> 0.76–0.93, PEA 73,7%–91.7%) and PD (κ<sup>w</sup> 0.80–0.95, PEA 80.0%–95.0%), and good for GS (0.61–0.74, PEA 68.9%–80.6%). The average (range) PCA for both intra- and inter-reader reliability was 99.0% (83.5%–100%). <h3>Conclusions</h3> This encouraging reliability exercise demonstrates that with current available US atlases of OP, GS and PD, one can obtain good to excellent agreement on US scorings even with limited experience. Since US is an operator dependent modality, we suggest that an atlas should be included in US studies of hand OA patients. <h3>References</h3> Hammer HB, Bolton-King P, Bakkeheim V, et al. Examination of intra and interrater reliability with a new ultrasonographic reference atlas for scoring of synovitis in patients with rheumatoid arthritis. Ann Rheum Dis. 2011 Nov; 70(11):1995-1998. Mathiessen A, Haugen IK, Slatkowsky-Christensen B, et al. Ultrasonographic assessment of osteophytes in 127 patients with hand osteoarthritis: exploring reliability and associations with MRI, radiographs and clinical joint findings. Ann Rheum Dis. 2013 Jan; 72(1):51-56. <h3>Disclosure of Interest</h3> None declared
SAT0147 Self-Reported Flares Predict Radiographic Progression in Rheumatoid Arthritis Patients in Remission Undergoing Etanercept Tapering
Authors: F. Ometto, B. Raffeiner, L. Bernardi, K. Botsios, L. Punzi, A. Doria
Journal: Annals of the Rheumatic Diseases (2015)
AB0709 Risk Factors of Digital Ulcers in Patients with Systemic Sclerosis: An Observational Study From a Single Center in South Korea: Table 1.
Authors: K.H. Jung, W. Park, S.R. Kwon, M.J. Lim
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Digital ulcer (DU) is a significant cause of pain, functional disability and quality-of-life impairment in patients with systemic sclerosis (SSc). DU can occur even in patients with very early/early SSc (called the “window of opportunity” of SSc). Therefore, the identification of risk factors of DU can improve the SSc outcome. Several large cohort studies have reported risk factors of DU in SSc [1]. However, the risk factors of DU in patients with SSc have not been described in Korea yet. <h3>Objectives</h3> To determine the prevalence and risk factors of DU in Korean patients with SSc. <h3>Methods</h3> Ninety consecutive SSc patients with at least 6 months of follow-up were enrolled from January 2014 to December 2014 in tertiary hospital rheumatism center. Demographic data, clinical characteristics, internal organ involvements, comorbidities, laboratory findings, and disease-specific factors were obtained through medical records and patients interviews, retrospectively. <h3>Results</h3> Thirty-seven patients (41%) had a history or present digital ulceration and 43% of them had recurrent DU. Patients with DU were thin, had higher modified Rodnan skin score (mRSS), showed frequent pigmentation, microsomia, finger flexion contracture, acroosteolysis and calcinosis. They had anti-Scl 70 antibody, advanced nailfold capillary changes (active and late pattern) and interstitial lung disease more frequently than in patients without DU (Table 1.). In a multiple logistic regression analysis, mRSS (OR =1.178, 95% C.I. =1.06-1.31, p-value =0.002) was the sole risk factor of DU. A nailfold capillary microscopic finding was the only risk factor of recurrence of DU (p-value =0.025). <h3>Conclusions</h3> In Korean SSc patients, Rodnan skin score is a risk factor of DU and advanced nailfold capillary change is a risk factor for recurrent DU. We need more attention to treat those SSc patients with high mRSS and advanced nailfold capillary change. <h3>References</h3> Silva I, Almeida J, Vasconcelos C. A PRISMA-driven systematic review for predictive risk factors of digital ulcers in systemic sclerosis patients. Autoimmun Rev. 2015;14(2):140-152 <h3>Disclosure of Interest</h3> None declared
RARE-07RECURRING PITUITARY CYST WITH HISTOLOGY OF XANTHOMATOUS HYPOPHYSITIS: FIRST CASE REPORT OF SURGICALLY TREATED RECURRENCE AND LITERATURE REVIEW
Authors: Mansour Mathkour, Juanita Garces, Tyler Scullen, Edison Valle, Shams Halat, Teresa Arrington, Marcus Ware
Journal: Neuro-Oncology (2015)

INTRODUCTION: Xanthomatous hypophysitis (XH) is the rarest histological type of primary hypophysitis. It is non lymphocytic in nature, and is characterized by an infiltration of pituitary gland by lipid-laden histiocytes and macrophages. Consequent to a shared location, the clinical and radiological features of XH overlap heavily with pituitary adenomas and are prone to misdiagnosis. In this report we describe a case of newly diagnosed XH, which recurred after 1 year and was treated surgically. CASE: A 45-year-old female presented with history of menstrual irregularity for 9 months and a history of amenorrhea, galactorrhea and headache for 2 months duration. Preoperative endocrinologic studies showed increased prolactin. Magnetic resonance imaging (MRI) of the sella showed a cystic lesion with suprasellar extension suggestive of a pituitary adenoma. The patient underwent transsphenoidal resection that revealed a thick yellowish colloidal material. Histopathology demonstrated necrotic tissue with no definitive diagnosis and no identified microorganisms. The patient resumed her normal menstrual cycle with serum prolactin levels normalizing at 2-months post surgery. At 1-year post surgery her menstrual cycle again became irregular. A repeat MRI showed a recurrent mass and she underwent a second transsphenoidal resection. Repeat histopathology was consistent with XH. At present, the patient is at 5-years post initial surgery and is doing very well without evidence of recurrence. CONCLUSION: To the best of our knowledge, there are 18 prior reported cases in the literature of XH and two reported cases of recurrent disease. The clinical and radiological features of XH are undistinguished form pituitary adenoma. These lesions present similarly to nonfunctional adenomas and diagnosis is often difficult without surgical pathology, necessitating meticulous immunohistochemistry to prevent misdiagnosis. As such, XH should be considered as a rare etiology in the differential of both newly diagnosed and recurrent sellar-region lesions.
AB0312 Anti-Cyclic Citrullined Peptide and Ultrasound Activity in Rheumatoid Arthritis: Table 1.
Authors: W. Hamdi, S. Miladi, R. Dhahri, I. Cherif, I. Zouch, D. Kaffel, M. Kchir, M. Chelli, F. Ladab
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the presence of rheumatoid factor (RF) and anti-cyclic citrullined peptide (ACPA). ACPA have higher specificity than RF for RA, and are associated with joint radiographic damage and extra-articular manifestations. <h3>Objectives</h3> The aim of this study was to evaluate the US RA activity whether the ACPA were present or not. <h3>Methods</h3> A cross-sectional study of patients followed-up for RA was conducted. Demographic, clinical and biological data were collected. RF and ACPA mesures were collected from medical records. We calculated the US-DAS28 in order to evaluate accurate activity of RA. All patients had an ultrasound (US) examination of 22 joints of hands (wrists, metacarpophalangeal, proximal interphalangeal). US was performed by an operator blinded to clinical and laboratory data. RA activity was evaluated by US-DAS28 by replacing swollen joints of the hands by joints expressing synovial hypertrophy or hyper vascularization in US. <h3>Results</h3> One hundred and eighteen patients were enrolled, 83% were females. The mean age was 53 years-old. The mean duration of the disease was 11.6 months. The RF was positive in 64 (55%) patients and the ACPA was positive in 31 (26%) patients. The median DAS28 was 5,52 [2,91-7,81]. The medianUS-DAS28 was 5.29 [1.98- 7.83]. The comparison between US-DAS28 according to immunological status is showed in table 1. <h3>Conclusions</h3> We conclude that there was no significant difference of RA activity between seropositive or seronegative RA and also whether ACPA was positive or not. The analysis of bone damages should be compared in another study order to determinate the prognostic value of ACPA. <h3>References</h3> Jung C, Jisuk B. Relation of rheumatoid factor and anti cyclic citrullined peptide antobody with disease activity in rheumatoid arthritis: cross sectional study. Rheumatol Int 2013. <h3>Disclosure of Interest</h3> None declared
PTU-318 The impact of an inflammatory bowel disease nurse-led biologics service
Authors: NS Taylor, M Bettey, S Kerr, J Wright, JRF Cummings
Journal: Gut (2015)

<h3>Introduction</h3> Southampton General Hospital is a busy teaching hospital providing specialist IBD services for a population of 650,000. Biologics have impacted hugely on the management of IBD but are high cost drugs requiring careful supervision. The absence of a clear biologics pathway made it challenging to provide the support required so we developed a specialist nurse-led biologics service to improve our IBD service. <h3>Method</h3> In 2010, an audit of biological therapies in 85 patients highlighted areas for improvement in monitoring and follow-up. A business case was developed to establish a nurse specialist to identify patients on biologics and ensure all received appropriate screening, education, and review. A 50/50 gain share was agreed with Southampton City and West Hampshire Primary Care Trust for 2013/14 onwards. The trust invested £60,000 to deliver service improvements. Outcomes were re-audited in 2014. <h3>Results</h3> In 2010, 17% of patients had a clear management plan documented. An infection screen was documented in 79% and chest x-ray in 56% of patients. 80% were reviewed ≤12 weeks post-induction to assess primary response, 1/3 were reviewed in clinic in ≤6 months, with 20% seen less than once a year. Treatment continuation decisions were documented in 73%. Biologic use has grown rapidly from 90 patients in 2011, to 328 in 2013. All prescription records are now kept in a centralised database. In the 2014 audit, infection screening and chest x-ray were documented in 100% of patients. 96% of patients had follow up ≤4 months post-induction to assess primary response, but 2 patients were seen 7 months post-induction. 80% were followed up again at 9–12 months (100% at 9–14 months) to assess appropriateness of treatment continuation, all with documentation of decision regarding ongoing treatment. The service has proved cost-effective: 109 biologics were discontinued from 2012–2014 and the £60,000 investment was recouped by March 2014 through 350 outpatient appointments and 35 colonoscopies. Research recruitment resulted in 77 patients participating in biologics trials since 2012, providing further income to the trust. <h3>Conclusion</h3> The specialist IBD biologics nurse-led service has resulted in significant gains in care quality and cost savings, fulfilling the IBD standards<sup>1</sup>by delivering high quality clinical care and a patient-centred service. The need for improved follow up of patients on biologics reflects increased pressures on clinic resources across the country. The introduction of a biologics nurse has provided invaluable support to our patients and facilitated the development of the IBD team at Southampton General Hospital. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> The IBD Standards Group, 2009 http://www.bsg.org.uk/attachments/160_IBDstandards.pdf. – Accessed 10th September 2014
Aspirin and the Kidney
Authors: R D Wigley
Journal: BMJ (1974)

A survey of 763 patients with rheumatoid arthritis and 145 with osteoarthritis in six clinics in New Zealand showed no association between aspirin intake and a score designed to detect analgesic nephropathy. Analgesic nephropathy was diagnosed clinically in three patients taking APC (aspirin, phenacetin, and caffeine or codeine or both) and in one who took aspirin and phenylbutazone and was suspected in one who took aspirin and paracetamol. Isolated aspirin was not implicated. The study showed that most people can take large quantities of salicylates without renal injury. The findings are, however, consistent with the view that there is a risk from APC compounds taken in large quantity, but the numbers at risk in this study were small. Aspirin may have an additive effect with other analgesics in causing renal damage. An increased frequency of urinary tract symptoms in those taking analgesics requires further investigation.
Needed: qualitative improvement in antisarcoma therapy.
Authors: J H Edmonson
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.7.1531 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7602340 Needed: qualitative improvement in antisarcoma therapy. J H EdmonsonxJ H EdmonsonSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.7.1531 First Page PDF © 1995 by American Society of Clinical Oncology
Retroviral transfer of the recombinant human erythropoietin receptor gene into single hematopoietic stem/progenitor cells from human cord blood increases the number of erythropoietin-dependent erythroid colonies
Authors: L Lu, Y Ge, ZH Li, W Keeble, D Kabat, GC Bagby, HE Broxmeyer, ME Hoatlin
Journal: Blood (1996)