tbuckley/cabot-search huggingface dataset:
AB0069 Cytokines Genes Expression in Peripheral Blood in Patients with Localized and Generalized Forms of Granulomatosis with Polyangiitis: Table 1.
Authors: I. Lopatina, S. Moiseev, M. Mezentseva, P. Novikov, L. Russu, E. Isaeva
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To evaluate the cytokine profile in patients with localized and generalized forms of granulomatosis with polyangiitis (GPA). <h3>Methods</h3> We enrolled in our study patients with GPA that complied with the ACR criteria and the CHCC-2012 definitions. Group with localized form of GPA consisted of 25 patients with upper and/or lower respiratory tract disease. 33 patients had generalized form of GPA - renal vasculitis with serum creatinine &lt;500 μmol/L or/and imminent vital organ failure. Cytokines genes expression was studied in blood by reverse transcription polymerase chain reaction. We evaluated mRNA for the following cytokines: interferon (IFN)-α, IFN-γ, interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-18, tumor necrosis factor (TNF)-α production. Control group consisted of 40 healthy volunteers. <h3>Results</h3> There were 58 patients with GPA aged from 18 to 77 years (19 male and 39 female). Majority of them were positive for ANCA (87%), mostly to proteinase-3, and had biopsy-proven diagnosis (64%). Patients with generalized and localized forms of GPA had higher proportion of blood samples expressing IFN-α mRNA and lower proportion of samples expressing IL-12 and TNF-α mRNA as compared with controls (table). As compared with controls, expression of IL-2 and IL-8 mRNA occurred more frequently only in patients with generalized GPA, whereas expression of IFN-γ mRNA occurred less frequently only in patients with localized GPA. The differences between patients with generalized and localized GPA were insignificant. <h3>Conclusions</h3> GPA is associated with different changes in cytokines genes expression. Patients with generalized GPA more frequently showed expression of mRNA of IL-2 (stimulates B-cell increase and immunoglobulin production) and Il-8 (regulates immune cells migration). These data warrant further studies of aforementioned cytokines as possible markers of GPA generalization. <h3>Disclosure of Interest</h3> None declared
THE EFFECT OF ELECTROSHOCK ON A "NORMAL" PERSON UNDER RECENT STRESS
Authors: LEO ALEXANDER
Journal: American Journal of Psychiatry (1953)

After an experimental application of electroshock a prior stressful event was disregarded—Stripped of its associative connections—in the manner consistent with the defensive operation known as isolation. Neutral events that occurred both before and after the stressful event were clearly remembered after the electroshock. Clinical studies to be reported elsewhere (I) indicate that the arousal or enhancing of active defensive operations appears to be the most decisive effect of convulsive electroshock treatment. It is probably for that reason that ECT is helpful in those conditions in which defensive operations are at a low ebb, ineffective or exhausted, such as in depression and other severely regressive psychotic states, but that it is ineffective—in fact disturbing—in those conditions in which defensive operations are already too disturbingly alerted, constituting an obstacle to treatment and recovery, such as in anxiety states.
FRI0371 Autoimmune Diseases in Patients with Rheumatoid Arthritis
Authors: T.A. Simon, H. Kawabata, J.M. Esdaile, V. Moorthy, S. Suissa
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> RA is one of about 80 different types of autoimmune diseases. After cancer and heart disease, autoimmune diseases are the most common type of disease in the US, with an estimated prevalence of 3.2% and 5.9% in the US<sup>1</sup> and Europe,<sup>2</sup> respectively, depending on the source, with a corresponding increase in mortality.<sup>3</sup> Many autoimmune diseases share a common pathogenic mechanism, but there are few published studies quantifying the occurrence of other autoimmune diseases in patients with RA. <h3>Objectives</h3> To estimate the prevalence of concomitant autoimmune diseases in an RA population and a matched osteoarthritis (OA) population. <h3>Methods</h3> Using a US medical claims database, patients with RA or OA were identified in the MarketScan Commercial and Medicare Supplemental databases. Patients were required to have at least 180 days of continuous health plan enrolment before the qualifying RA or OA diagnosis between 1 January 2006 and 30 September 2013. For each of the RA cohort members, 5 age- and sex- frequency-matched OA patients were identified. Study index date corresponded to the first qualifying RA or OA diagnosis date during the study period. Prevalence rates and rate ratios with 95% CIs for the 28 prespecified autoimmune diseases during the 6-month period before the index date were computed, comparing the RA and OA cohorts. <h3>Results</h3> A total of 200,000 RA and 1 million age- and sex-matched OA patients were studied. The top ten most frequent autoimmune diseases measured by prevalence rate are presented (see Table). Patients with RA were almost three times more likely to have at least one autoimmune disease in their history compared with patients with OA. In particular, patients with RA were 17.9 times more likely to have a concomitant diagnosis of psoriatic arthritis and more than 8.7 times more likely to have a concomitant diagnosis of lupus or Sjögren9s syndrome than their age- and sex-matched OA counterparts. <h3>Conclusions</h3> The presence of autoimmune diseases in patients with RA is much more frequent than in patients with OA. Our data suggest that the inter-relationship of RA with other autoimmune diseases, and the outcomes associated with the occurrence of multiple autoimmune diseases, may play an important role in treatment decisions and the understanding of autoimmune diseases as outcomes. <h3>References</h3> Jacobson DL, et al. Clin Immunol Immunopathol 1997;84:223–43 Eaton WW, et al. J Autoimmun 2007;29:1–9 Walsh SJ, Rau LM. Am J Public Health 2000;90:1463–6 <h3>Disclosure of Interest</h3> T. A. Simon Employee of: Bristol-Myers Squibb, H. Kawabata Shareholder of: Bristol-Myers Squibb, Employee of: Bristol-Myers Squibb, J. M. Esdaile: None declared, V. Moorthy Consultant for: Bristol-Myers Squibb, S. Suissa Consultant for: Bristol-Myers Squibb, Genentech, Roche
Response of patients to participation in psychiatry board examinations
Authors: H Rosen, L B Cohen, L Schwartz, J N Digiacomo
Journal: American Journal of Psychiatry (1979)

The patient who volunteers to be a subject for Part II of the certifying examination in psychiatry and neurology is an indispensable but surprisingly invisible participant in a highly controversial process. A survey of the attitudes of 78 patients toward this experience revealed that although they experienced a significant degree of stress, the overwhelming majority viewed their participation in strongly positive terms. The patient's loyalty to the host institution and the manner in which the patient is prepared for the experience appear to be the major factors in determining a positive outcome.
PTH-250 Clinical course and management of norovirus infection following small bowel transplantation in children
Authors: K Nikaki, M Patel, J Hartley, L Ibarra, K Guthrie, G Gupte
Journal: Gut (2015)

<h3>Introduction</h3> Noroviruses are a common cause of acute gastrointestinal illness worldwide and can be life-threatening in immunocompromised patients e.g. intestinal transplantation (ITx).<sup>1,2</sup>No treatment is currently available for Norovirus infection. <h3>Method</h3> The Noroviral status of 85 paediatric ITx recipients at Birmingham Children’s Hospital (1993–2014) was recorded and the first episode of gastroenteritis was identified. <h3>Results</h3> 20 patients developed Noroviral gastroenteritis (12F:8M). 7 patients received isolated ITx, 11 combined liver and ITx and 2 multivisceral transplant. The mean age at transplantation was 7.2 yrs (range 11 months – 10 yrs) and at diagnosis of Noroviral infection 10.15 yrs (range 1–17 yrs). The mean time interval of transplantation and Noroviral infection was 2.15 yrs (range 2 months- 15 yrs). The time of hospitalisation varied significantly depending on the co-morbidities (5–114 days). 9 patients received intensified immunosuppression within the last 3 months prior to Noroviral infection due to rejection, PTLD, GvHD or other autoimmune process. All patients presented with increased stool output, while 5 also presented with vomiting and 9 with dehydration. The immunosuppressive regime included Tarolimus and Prednisolone in 13 patients and a combination of Tacrolimus, Prednisolone, MMF, Sirolimus, Infliximab and Azathioprine in the rest. 6 patients developed rejection, 5 had a concomitant stool infection, 2 were diagnosed with PTLD and 7 had a systemic infection. 7 patients required parenteral nutrition (PN) and 14 received oral human immunoglobulins (OHIG) as part of their treatment. The outcome for 2 patients was death (both diagnosed with PTLD). All other patients managed to re-establish enteral feeds with 4 needing extra overnight IV fluids or PN. On average, the children treated with OHIG were younger with a shorter time interval between Noroviral gastroenteritis and ITx. OHIG reportedly shortens the period of diarrhoea<sup>3</sup>but we did not observe a shortened hospitalisation time. The histopathological appearances of norovirus can mimic rejection<sup>2</sup>and it is important to correlate clinically. <h3>Conclusion</h3> Norovirus is a significant pathogen in ITx and differentiation from rejection is crucial. OHIG may have a role in the treatment of ITx recipients. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Bok K, Green KY. <i>N Engl J Med</i>. 2012;367(22):2126–2132 Kaufman SS, <i>et al</i>. J Pediatr Gastroenterol Nutr., 2005;40(3):328–333 Florescu DF, <i>et al</i>. Pediatr Transplant. 2011;15(7):718–21
In vivo administration of recombinant human granulocyte/macrophage colony-stimulating factor in acute lymphoblastic leukemia patients receiving purged autografts [see comments]
Authors: BR Blazar, JH Kersey, PB McGlave, DA Vallera, LC Lasky, RJ Haake, B Bostrom, DR Weisdorf, C Epstein, NK Ramsay
Journal: Blood (1989)
In Vivo Effects Of Ibrutinib On The Migration Of Chronic Lymphocytic Leukemia Cells Differ Between Patients and Reduce The Ability Of The Bone Marrow Microenvironment To Attract The Tumor Cells
Authors: Sarah E. M. Herman, Jade Jones, Rashida Z. Mustafa, Mohammed Farooqui, Adrian Wiestner
Journal: Blood (2013)
The Use of Streptomycin in Colon-Bacillus Peritonitis
Authors: S. Richard Muellner, Alexander Rutenberg
Journal: New England Journal of Medicine (1946)

THE recorded clinical experience with streptomycin is as yet quite meager. The technic of administering this drug and the dosage to be employed in infections with various bacteria have not yet been established. The variation in susceptibility of different strains of the same bacteria and the rapid development of fastness in experiments in vitro suggest that a clinical evaluation of these factors is desirable.1 2 3 The pooling of clinical experience with streptomycin in carefully studied cases therefore seems to be worthwhile. It is with this purpose in mind that the following report is presented.Case ReportW. S. (BIH 67286), a . . .
Point Lobos
Authors: Janet M. Torpy
Journal: JAMA (2011)

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AB0707 Initial Limited Three-Level Thin-Section Computed Tomography Scorings Predict the Prognosis of Acute/Subacute Interstitial Pneumonia in Patients with Dermatomyositis
Authors: J. Konma, T. Kotani, T. Ishida, K. Oda, K. Isoda, K. Hata, Y. Yoshimatsu, T. Takeuchi, S. Makino, T. Hanafusa
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Interstitial pneumonia (IP) is a common complication of dermatomyositis (DM), causing increased morbidity and mortality. DM with acute/subacute IP (A/SIP) progresses rapidly and the prognosis is poor. Previous studies have reported the following adverse prognostic factors: high initial serum ferritin level, high alveolar arterial oxygen gradient (AaDO<sub>2</sub>), low vital capacity, negative anti-aminoacyl tRNA synthetase (ARS) antibody, and positive anti-melanoma differentiation associated gene (MDA) 5 antibody. It is crucial to enable early prognosis prediction at the time of DM-A/SIP diagnosis. <h3>Objectives</h3> We examined to predictable of the prognosis from chest high-resolution computed tomography (HRCT) image of DM/A/SIP. <h3>Methods</h3> Data were obtained retrospectively from medical records of 20 consecutive DM-A/SIP patients admitted to Osaka Medical College Hospital and Yodogawa Christian Hospital between July 2011 and January 2014. Chest HRCT images were reviewed by 3 independent observers blinded to clinical information, and quantified using the CT score including both ground-glass opacity (GGO) score and fibrosis score as defined by Kazerooni. Each patient9s lobe was scored by same observers and using the average value. Briefly, limited 3 CT levels were pre-selected: aortic arch, the carina, and 1 cm above the diaphragm. Each lobe (right upper, middle, and lower, and left upper and lower lobes) of the lung was scored at the 3 sites on a scale of 0-5. <h3>Results</h3> Of the 20 patients, 7 died of IP. No significant differences were observed in patients background excluding anti-ARS antibody positivity and anti-MDA 5 antibody positivity between survivors and those who died. No significant differences were observed in chest HRCT findings between them. GGO scores in both upper lobes and the right middle lobe were significantly higher in the fatalities (P=0.01, 0.001, 0.02), but there was no significant difference in both lower lobes. Fibrosis scores in the right middle lobe was significantly higher in the fatalities (P=0.02), but there was no significantly difference in other lobes. A right middle lobe GGO score of ≥3 was determined as the best cut-off value for a poor prognosis (sensitivity: 85.7%, specificity: 85.7%), and the survival rate after 24 weeks was significantly lower in patients with a right middle lobe GGO score of ≥3 (survival rate: 0.0%) than in those with &lt;3 (92.9%) (<i>P</i> &lt;0.0001). <h3>Conclusions</h3> Initial limited three-level thin-section CT scorings may be a useful prediction marker of DM-A/SIP. <h3>Acknowledgements</h3> Takao Kamimori, Hiroshi Fujiwara, Yodogawa Christian Hospital <h3>Disclosure of Interest</h3> None declared
AB1117 24 Hour Crystal Microscopy Improves Diagnosis in Cases of CPPD
Authors: E. Reilly, J. Wilcox, T. Maggs, K. Mackay
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Acute monoarthritis presents a diagnostic challenge on call and generates many inpatient Rheumatology referrals. Patients may undergo unnecessary intravenous antibiotics or arthroscopy for fear of missing septic arthritis. Calcium pyrophosphate deposition disease (CPPD) is the most challenging crystal arthropathy to prove on synovial fluid analysis, due to the relative fragility of crystals and lack of persistent at microscopy. We present an example of service change which altered diagnostic rates for crystal arthropathies, and would streamline care. <h3>Objectives</h3> To assess the effect of widened access to crystal microscopy in the management of acute monoarthritis in a district general hospital. <h3>Methods</h3> Regional histopathology and local microbiology databases were reviewed for synovial aspirates between January 2013 and June 2014. This spanned a change from histopathology to microbiology as primary laboratory for analysis in December 2013. Microbiology were trained in crystal microscopy, and the service was extended from 9am-5pm to 24 hour. Results were cross-referenced with Cyberlab biochemical result system for further details. Timings of lab samples were recorded. <h3>Results</h3> 180 synovial fluid samples were received during January to December 2013, and 155 during December 2013 to June 2014 in our hospital. Graph 1 shows the change in results across the service change. Most notably the rates of CPPD rose substantially and amorphous crystalline debris fell. A&amp;E admission rates also fell. All samples pre intervention were analysed within working hours. 24 hour microscopy service saw 59% of samples analysed out of hours (5pm-9am or weekends). Wait times for sample analysis fell from 46 hours to 11.8 with the change in service. <h3>Conclusions</h3> Service development has led to demonstrable changes in diagnoses (increased rates CPPD, reduced amorphous crystalline debris, but maintained rates of MSU and negative results). Accurate early diagnosis reduces admissions and would reduce patient exposure to unnecessary procedures. <h3>References</h3> Zhang et al. European League Against Rheumatism recommendations for calcium pyrophosphate deposition. Part I: terminology and diagnosis. Ann Rheum Dis 2011 Apr;70(4):563-70. doi: 10.1136/ard.2010.139105. Epub 2011 Jan 7. Tausche et al. A 3-day delay in synovial fluid crystal identification did not hinder the reliable detection of monosodium urate and calcium pyrophosphate crystals. J Clin Rheumatol 2013 Aug;19(5):241-5. doi: 10.1097/RHU.0b013e31829cde53. <h3>Acknowledgements</h3> Many thanks to the laboratory staff at Torbay Hospital. <h3>Disclosure of Interest</h3> None declared
Unilateral Gottron Papules in a Patient Following a Stroke
Authors: Drew J. B. Kurtzman, Allen Ho, Natalie A. Wright, Mitchell H. Rubenstein, Ruth Ann Vleugels
Journal: JAMA Dermatology (2016)

differences in hair coverage. 3,5 The natural photoprotective effect offered by hair is quantitated as exponential to scalp hair density. 5 Therefore, patients with alopecia should be counseled on using additional sun protection by wearing hats with complete coverage for the scalp; applying SPF 30+ sunscreen lotion, spray or stick; or using handheld umbrellas to further minimize exposure to UV radiation.Since baseball caps remain a popular style among US adults, the general public, particularly men at risk of developing androgenetic alopecia, should be made aware of their shortcomings in photoprotection and should be counseled to use additional means to protect against skin cancer development, especially on the scalp.
THU0509 First 18 Month Report of Iranian Periodic Fever and Autoinflammatory Registry (IPFAIR)
Authors: F. Mehregan, V. Ziaee, M.H. Moradinejad, Y. Aghighi, S.R. Raeeskarimi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> The term Auto-inflammatory diseases (AIDs) has been used to describe a group of illness characterized by attacks of seemingly unprovoked inflammation without a significant level of either autoantibodies or antigen-specific T cells more characteristic of autoimmune disease. Published data from Iran regarding autoinflammatory disease in children are scarce. In a multicenter effort, we set out to register genetic, epidemiological and clinical features as well as prognostic factors of these diseases by prospective longitudinal and long-term documentation, in order to define current and novel AIDs and to better understand treatment responses and outcome. <h3>Methods</h3> This study is a prospective cross sectional study of patients diagnosed with Auto-inflammatory diseases (AIDs) who was registered in the autoinflammatory computer database registration through periodic fever clinic, which was established for this reason in the medical center of children in 23.09.2012 in Tehran- Iran and data were collected with standardized forms. Inclusion criteria are disease-associated mutations for hereditary periodic fever syndromes [FMF, hyperimmunoglobulinaemia D and periodic fever syndrome (HIDS), TNF receptor 1-associated periodic syndrome (TRAPS) and cryopyrin-associated periodic syndrome (CAPS)], or, alternatively, clinically confirmed AID, and periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome with the unknown genetic background. <h3>Results</h3> During the first 18 months, 139 patients (93 males, 46 females) from 27 provinces and 11 ethnicities; age (newborn to 18 years) have been recorded and classified as FMF (n=102), PFAPA (n=29), HIDS (n=1), clinically confirmed AID (n=6) including TRAPS (n=1) and CAPS (n=2); CRMO (n=2), DIRA (n=1), and sweet syndrome (n=1). The most common AID in our study were FMF and then PFAPA, CRMO, CAPS. The most common ethnicity was Turkish and Kurdish people. In total 139 patients, genetic analysis was performed in 103 patients, 88.37% have genetically confirmed disease. <h3>Conclusions</h3> Recruitment and follow-up of patients with AID will enable us to comprehensively address the correlation between clinical and epidemiological data, genetics. <h3>References</h3> INFEVERS: the Registry for FMF and hereditary inflammatory disorders mutations. Nucleic Acids Res, vol 31 A retrospective review of autoinflammatory diseases in Saudi children at a rheumatology clinic. Ann Saudi Med 2012 Jan-Feb;32(1):43-8. <h3>Disclosure of Interest</h3> None declared
Decision Making in Liver Transplant Selection Committees
Authors: Michael L. Volk, Scott W. Biggins, Mary Ann Huang, Curtis K. Argo, Robert J. Fontana, Renee R. Anspach
Journal: Annals of Internal Medicine (2011)

To better understand how liver transplant centers make decisions to list patients for liver transplantation, researchers observed selection committee meetings at 4 centers in the United States and ...