tbuckley/cabot-search huggingface dataset:
GLANDULAR FEVER (INFECTIOUS MONONUCLEOSIS)
Authors: H TIDY
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer.
Authors: Neil Howard Segal, Ajay K. Gopal, Shailender Bhatia, Holbrook Edwin Kohrt, Ronald Levy, Michael J. Pishvaian, Roch Houot, Nancy Bartlett, Paul Nghiem, Stephanie Anne Kronenberg, Aron D. Thall, Ganesh Mugundu, Bo Huang, Craig Davis
Journal: Journal of Clinical Oncology (2014)

3007 Background: 4-1BB agonists markedly enhance cytotoxic T-cell responses, resulting in anti-tumor activity in several models. PF-05082566 is a fully humanized IgG2 agonist monoclonal antibody targeting 4-1BB.This portion of the first-in-human phase I study assessed the safety, pharmacokinetics (PK), pharmacodynamics (PD) and antitumor activity of PF-0508256 monotherapy in patients with advanced cancer. Methods: An open-label, dose escalation study was conducted in patients with advanced malignancies for which no curative therapy was available. Cohorts of 3-6 patients were enrolled initially using a 3+3 design (0.006 to 0.3 mg/kg), then a Time-To-Event CRM design for higher doses (0.6 to 5 mg/kg). Patients received PF-05082566 via intravenous infusion every 4 weeks (one cycle) with an 8 week period for assessment of dose-limiting toxicity (DLT). Radiographic assessments were conducted every 8 weeks, using RECIST 1.1. Results: 27 patients have been treated with PF-05082566 up to the 0.3 mg/kg dose level, including colorectal cancer (n=11), Merkel cell carcinoma (n=6), pancreatic adenocarcinoma (n=2), and one each of nasopharyngeal cancer, ampullary cancer, squamous cell lung cancer, carcinoma of unknown primary, melanoma, sarcoma, follicular lymphoma, and lymphocytic lymphoma (SLL). 25 patients completed the DLT assessment period and 7 patients remain on therapy. All discontinuations from treatment were due to disease progression. Median number of cycles ranged from 2 (at 0.006 mg/kg) to 7 (at 0.24 mg/kg). There was no apparent relationship between increasing doses and the frequency or severity of treatment emergent adverse events, which were mostly Grade 1. One patient treated at 0.06 mg/kg had Grade 3 elevation in alkaline phosphatase. No additional significant elevations in liver enzymes and no DLTs have occurred to date. Preliminary PK data suggests a linear increase in drug exposure with increasing dose, and a half life of ~10 days. A best overall response of stable disease was observed in 22% (6/27) patients. Conclusions: PF-05082566 was well tolerated, with evidence of disease stabilization in multiple patients. Enrollment continues at higher dose levels to obtain additional safety, PK, PD, and efficacy data. Clinical trial information: NCT01307267.
Particulate Matter and Subclinical Atherosclerosis: Associations between Different Particle Sizes and Sources with Carotid Intima-Media Thickness in the SAPALDIA Study
Authors: Inmaculada Aguilera, Julia Dratva, Seraina Caviezel, Luc Burdet, Eric de Groot, Regina E. Ducret-Stich, Marloes Eeftens, Dirk Keidel, Reto Meier, Laura Perez, Thomas Rothe, Emmanuel Schaffner, Arno Schmit-Trucksäss, Ming-Yi Tsai, Christian Schindler, Nino Künzli, Nicole Probst-Hensch
Journal: Environmental Health Perspectives (2016)

Subclinical atherosclerosis has been associated with long-term exposure to particulate matter (PM), but the relevance of particle size and sources of exposure remains unclear.We investigated the association of long-term exposure to PM10 (≤ 10 μm), PM2.5 (≤ 2.5 μm: total mass, vehicular, and crustal sources), and ultrafine particles [UFP < 0.1 μm: particle number concentration (PNC) and lung-deposited surface area (LDSA)] with carotid intima-media thickness (CIMT).We used data from 1,503 participants ≥ 50 years old who participated in the third examination of the Swiss SAPALDIA cohort. Exposures were obtained from dispersion models and land-use regression models. Covariate information, including previous cardiovascular risk factors, was obtained from the second and third SAPALDIA examinations.The adjusted percent difference in CIMT associated with an exposure contrast between the 10th and 90th percentile was 1.58% (95% CI: -0.30, 3.47%) for PM10, 2.10% (95% CI: 0.04, 4.16%) for PM2.5, 1.67% (95% CI: -0.13, 3.48%) for the vehicular source of PM2.5, -0.58% (95% CI: -3.95, 2.79%) for the crustal source of PM2.5, 2.06% (95% CI: 0.03, 4.10%) for PNC, and 2.32% (95% CI: 0.23, 4.40%) for LDSA. Stronger associations were observed among diabetics, subjects with low-educational level, and those at higher cardiovascular risk.CIMT was associated with exposure to PM10, PM2.5, and UFP. The PM2.5 source-specific analysis showed a positive association for the vehicular source but not for the crustal source. Although the effects of PNC and LDSA were similar in magnitude, two-pollutant and residual-based models suggested that LDSA may be a better marker for the health relevance of UFP. Citation: Aguilera I, Dratva J, Caviezel S, Burdet L, de Groot E, Ducret-Stich RE, Eeftens M, Keidel D, Meier R, Perez L, Rothe T, Schaffner E, Schmit-Trucksäss A, Tsai MY, Schindler C, Künzli N, Probst-Hensch N. 2016. Particulate matter and subclinical atherosclerosis: associations between different particle sizes and sources with carotid intima-media thickness in the SAPALDIA study. Environ Health Perspect 124:1700-1706; http://dx.doi.org/10.1289/EHP161.
Safety and Efficacy Of Abbreviated Induction With Only 4 Cycles Of Fludarabine (F), Cyclophosphamide (C) and Rituximab (R) In Physically Fit Patients With Chronic Lymphocytic Leukemia (CLL) Who Achieve Early Complete Remission (CR) With Undetectable Minimal Residual Disease (MDR)
Authors: Carolina Pavlovsky, Astrid Pavlovsky, Isolda Fernandez, Adriana Galeano, Francisco Lastiri, Santiago Pavlovsky
Journal: Blood (2013)
Proton Pump Inhibitors and Dementia Incidence
Authors: Kanika Sharma, Alireza Minagar, Hai Sun
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Computed tomography enterography as a tool for identifying pancreaticojejunal anastomoses in patients who have undergone Whipple’s resection
Authors: So Nakaji, Nobuto Hirata, Toshiyasu Shiratori, Masayoshi Kobayashi
Journal: Endoscopy (2015)

During the endoscopic treatment of stenotic pancreaticojejunal anastomoses in patients who have undergone Whipple's resection, it can be difficult to identify the pancreaticojejunal anastomotic site [1] [2]. To solve this problem, we used computed tomography (CT) enterography to obtain detailed information about the pancreaticojejunal anastomotic site. We report a case in which a stenotic pancreaticojejunal anastomosis was identified and treated with the help of CT enterography.
Suicide Rates by Occupational Group — 17 States, 2012
Authors: Wendy LiKamWa McIntosh, Erica Spies, Deborah M. Stone, Colby N. Lokey, Aimée-Rika T. Trudeau, Brad Bartholow
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In 2012, approximately 40,000 suicides were reported in the United States, making suicide the 10th leading reported cause of death for persons aged ≥16 years (1). From 2000 to 2012, rates of suicide among persons in this age group increased 21.1%, from 13.3 per 100,000 to 16.1 (1). To inform suicide prevention efforts, CDC analyzed suicide by occupational group, by ascribing occupational codes to 12,312 suicides in 17 states in 2012 from the National Violent Death Reporting System (NVDRS) (2). The frequency of suicide in different occupational groups was examined, and rates of suicide were calculated by sex and age group for these categories. Persons working in the farming, fishing, and forestry group had the highest rate of suicide overall (84.5 per 100,000 population) and among males (90.5); the highest rates of suicide among females occurred among those working in protective service occupations (14.1). Overall, the lowest rate of suicide (7.5) was found in the education, training, and library occupational group. Suicide prevention approaches directed toward persons aged ≥16 years that enhance social support, community connectedness, access to preventive services, and the reduction of stigma and barriers to help-seeking are needed.
Soundings: What was it like for you?
Authors: Kevin Barraclough
Journal: BMJ (2000)

What was it like for you? It's all rather strange, this millennium business. I have to confess that I am one of those rather sad people who will happily retire to bed at 10 pm on New Year's Eve with a book and some malt whisky. The reason is partly bloody mindedness, and partly that I look like an ill conditioned bouncer when I wear a dinner jacket. However, it was clearly going to be impossible to impose my anchorite tendencies on my long suffering wife and eager children on this occasion.

There were two outcomes to our New Year celebrations: one predictable and the other less so. Predictably, I enjoyed it enormously despite being convinced that I was going to hate it. More surprisingly, I did feel an amorphous sense of awe as the clock struck midnight.

We were looking down on to the Severn flood plain and saw the entire vista explode with fireworks at midnight. It was the collectivity of the experience, with every little family house adding a few fireworks to the spectacle, which was extraordinary. And then it was gone. And the twentieth century was over, and irretrievable.

It was this latter finality which was somewhat daunting. The realisation that, in some way, the twentieth century had been our century, but that the twenty first belonged to the children playing tag around our feet on that hillside.

We returned home, slightly dazed from sleep deprivation and alcohol, and the sense of unreality persisted. A bright, sunny afternoon accentuated the sense of dislocation from the normal stream of time. I read a series of commentaries in the Scientific American comparing what was known at the beginning and end of this century, and what we might expect to learn in the next. The various authorities made conjectures with the caution you would expect from their wealth of experience. Apparently, insurmountable paradoxes, they wrote, like the incompatibility of quantum mechanics and general relativity, will surely be resolved, but the method of resolution of these problems will be entirely unexpected.

I'm sure the caution is justified. As someone once said, I have yet to see any problem, however complicated, which, when looked at in the right way, did not become still more complicated.
P-039 5-Fluorouracil Degradation Rate in Patients with Recurrent Gastrointestinal Cancer Treated with Metronomic Capecitabine
Authors: M. Roberto, A. Romiti, L. Lionetto, C. D'Antonio, C. Onesti, A. Botticelli, A. Milano, R. Falcone, M. Occhipinti, F. Mazzuca, M. Simmaco, P. Marchetti
Journal: Annals of Oncology (2016)
Supervision and privacy in psychotherapy training
Authors: R W Betcher, N E Zinberg
Journal: American Journal of Psychiatry (1988)

Supervision is an essential element of training in psychotherapy, and the issue of privacy in relation to the supervisory process is an important one. The authors examine the attitude toward privacy implicit in each of the two major models of supervision, the so-called didactic and countertransference models. They consider the ways in which supervision, particularly the countertransference model, and the use of audiovisual devices intrude on the privacy of the therapist and the therapy. Finally, they consider how the institutional and professional structures within which supervision takes place deal with the issue of privacy.
Aggressive treatment and survival outcomes in <i>NUT</i> midline carcinoma (NMC) of the head and neck (HN).
Authors: Nicole Grace Chau, Chelsey M Mitchell, Ali Aserlind, Noam Grunfeld, Leah Kaplan, Daniel E. Bauer, Christopher S. Lathan, Carlos Rodriguez-Galindo, Shelley Hurwitz, Roy B. Tishler, Robert I. Haddad, Stephen E. Sallan, James E. Bradner, Christopher Alexander French
Journal: Journal of Clinical Oncology (2014)

6057 Background: NMC is a rare subtype of squamous cancer defined by rearrangement of the NUT gene. NMC is typically found in the thorax, although ~20% of cases arise in the HN. NMC is almost uniformly fatal. We report on a cohort of patients (pts) with HN NMC to identify disease characteristics, treatment and outcomes. Methods: A clinical database was established using demographic and outcomes data available on all known cases of HN NMC obtained from the International NMC Registry (www.NMCRegistry.org). Clinicopathologic variables were assessed for 40 pts, the largest cohort of HN NMC studied to date. Outcome data from 31 patients treated from 1990-2013 were available for survival analyses. Results: HN NMC incidence has increased annually since 2010. Median age was 21.9 years (range 0.1-81.7), male: female (%) was 45:55, sinonasal origin was 50%, and the BRD4-NUT fusion was found in 82%. At diagnosis, 36% had regional node metastases and 15% had distant metastases. Initial treatment was upfront surgery (S) +/- adjuvant chemoradiation (CRT) or adjuvant radiation (RT) (48%), upfront RT +/- chemotherapy (C) (21%), or upfront C +/- S or RT (31%). Median progression-free survival (PFS) was 7.2 months (range 6.3-8.7). Median overall survival (OS) was 9.8 months (range 6.6-15.6). The 2-year PFS was 27% (95% CI, 9-44). The 2-year OS was 31% (95% CI, 13-50). Upfront S +/- post-operative CRT or RT, and S with negative margins were significant predictors of improved PFS and OS. Initial RT or C, type of C regimen, and NUT translocation type were not significantly associated with improved outcome. Conclusions: HN NMC portends a poor prognosis. Aggressive initial surgical resection with or without post-operative CRT or RT may be associated with enhanced survival. C or RT alone is inadequate, and the development of targeted therapies is now underway. PFS and OS by treatment. Treatment n 2-year PFS (95% CI) P value 2-year OS (95% CI) P value Initial upfront strategy S +/- CRT or RT 14* 55 (26-85) 0.01 55 (26-85) 0.01 RT +/- C 6 0 0 C +/- S or RT 8 0 14 (1-27) Extent of surgical resection None 13 0 0.03 8 (0-24) 0.03 Debulking 4 33 (0-88) 33 (0-88) Gross total 6 40 (0-84) 40 (0-84) Complete with negative margins 5 75 (32-100) 75 (32-100) * 12/14 had S then CRT, 1/14 had S then RT.
PD3-1-6: PF-3512676 (CPG 7909), a toll-like receptor 9 agonist-status of development for non-small cell lung cancer (NSCLC)
Authors: David R. Readett, Louis J. Denis, Arthur M. Krieg, Rebecca J. Benner, Donald C. Hanson
Journal: Journal of Thoracic Oncology (2007)
Implementation of RTS,S/AS01 Malaria Vaccine — The Need for Further Evidence
Authors: John Clemens, Vasee Moorthy
Journal: New England Journal of Medicine (2016)

In 2015, an estimated 438,000 people died from malaria.1 The overwhelming majority of these deaths occurred in young African children who were infected with Plasmodium falciparum. An effective vaccine would represent an important additional tool in the control of malaria. The most advanced of the current candidates against P. falciparum is RTS,S/AS01, a recombinant vaccine against the pre-erythrocytic stage of the parasite in which regions of P. falciparum circumsporozoite protein are fused to hepatitis B surface antigen.2 This vaccine was developed by a public–private partnership, with support from the Bill and Melinda Gates Foundation, and investigators have completed a . . .
Hypothalamic-pituitary-adrenal axis activity in panic disorder: prediction of long-term outcome by pretreatment cortisol levels
Authors: J L Abelson, G C Curtis
Journal: American Journal of Psychiatry (1996)

The authors sought to determine whether hypothalamic-pituitary-adrenal (HPA) axis activity in patients before their treatment for panic disorder can predict follow-up functional status. Although baseline HPA axis disturbances in patients with panic disorder appear to attenuate with treatment, there is evidence that they may be linked to poorer long-term outcomes.Follow-up clinical data were obtained for 18 of 20 patients with panic disorder who participated in a detailed study of HPA axis activity in panic, both before and during their treatment with alprazolam. HPA axis assessment included monitoring of adrenocorticotropin and cortisol over a full circadian cycle. The relationships between disability and clinical status at 2-year follow-up and HPA axis overactivity at entry were examined.Mean 24-hour cortisol levels before treatment provided a strong, positive predictor of disability scores at follow-up. Those patients who achieved the treatment goal of medication-free remissions had less evidence of HPA axis overactivity at entry than those who were not in remission.HPA axis activity before treatment did predict outcome 2 years later. This relationship appears robust and reproducible. Further work is needed to define the neuroendocrine mechanisms underlying the HPA axis markers that are linked to long-term functioning and to determine the biological, psychological, and social processes that link HPA axis disturbance to poorer outcomes.
Endothelial notch signaling is essential to prevent hepatic vascular malformations in mice
Authors: Henar Cuervo, Corinne M. Nielsen, Douglas A. Simonetto, Linda Ferrell, Vijay H. Shah, Rong A. Wang
Journal: Hepatology (2016)

Liver vasculature is crucial for adequate hepatic functions. Global deletion of Notch signaling in mice results in liver vascular pathologies. However, whether Notch in endothelium is essential for hepatic vascular structure and function remains unknown. To uncover the function of endothelial Notch in the liver, we deleted Rbpj, a transcription factor mediating all canonical Notch signaling, or Notch1 from the endothelium of postnatal mice. We investigated the hepatic vascular defects in these mutants. The liver was severely affected within 2 weeks of endothelial deletion of Rbpj from birth. Two‐week old mutant mice had enlarged vessels on the liver surface, abnormal vascular architecture, and dilated sinusoids. Vascular casting and fluorosphere passage experiments indicated the presence of porto‐systemic shunts. These mutant mice presented with severely necrotic liver parenchyma and significantly larger hypoxic areas, likely resulting from vascular shunts. We also found elevated levels of VEGF receptor 3 together with reduced levels of ephrin‐B2, suggesting a possible contribution of these factors to the generation of hepatic vascular abnormalities. Deletion of Rbpj from the adult endothelium also led to dilated sinusoids, vascular shunts, and necrosis, albeit milder than that observed in mice with deletion from birth. Similar to deletion of Rbpj, loss of endothelial Notch1 from birth led to similar hepatic vascular malformations within 2 weeks. Conclusions: Endothelial Notch signaling is essential for the development and maintenance of proper hepatic vascular architecture and function. These findings may elucidate the molecular pathogenesis of hepatic vascular malformation and the safety of therapeutics inhibiting Notch. (H epatology 2016;64:1302‐1316)
Focus on HIV in West and Central African Countries
Authors: M. J. Friedrich
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal