tbuckley/cabot-search huggingface dataset:
AB0831 Adaptation of the Psoriatic Arthritis Quality of Life (Psaqol) for use by Chinese and English Speakers in Singapore: Table 1.
Authors: Y.Y. Leung, M.B. Chua, M.E. Png, J. Twiss, S.P. McKenna
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Psoriatic Arthritis Quality of Life (PsAQoL) questionnaire is a disease-specific, patient-derived instrument for assessing quality of life (QoL) in psoriatic arthritis (PsA). <h3>Objectives</h3> The aim was to develop Singapore Chinese and English versions of the PsAQoL that were equivalent to, and met the same psychometric and acceptability standards as the original UK measure. <h3>Methods</h3> Translation of the original questionnaire into Singapore Chinese and English was performed by professional and lay translation panels. Field-testing for face and content validity was performed by interviewing 10 Chinese speaking and 10 English speaking local patients respectively. Sixty-one consecutive PsA patients (either Chinese or English speaking) fulfilling the CASPAR criteria from a single tertiary centre were then invited to participate in a validation survey that included socio-demographic and clinical data. The clinical variables, Health Assessment Questionnaire (HAQ) and Medical Outcome Short form 36 (SF-36) were used as comparator instruments for evaluating convergent validity. <h3>Results</h3> The validation sample included 70 patients (50.7% males), with a mean (SD) age of 52.5 (13.5) years. PsAQoL scores correlated with the HAQ (r=0.575, p&lt;0.0001), SF-36 physical summary score (r=-0.423, p&lt;0.0001), mental summary score (r=-0.547, p&lt;0.0001) and clinical disease activities. The scale was able to distinguish between groups with active or inactive disease and with different levels of self-reported general health. Test–retest reliability over 2 weeks was good (ICC =0.934, P&lt;0.0001). <h3>Conclusions</h3> This study provides evidence that the adapted English and Chinese versions of PsAQoL can be used in clinical studies and for determining long-term outcomes in PsA patients in Singapore. <h3>Disclosure of Interest</h3> None declared
Early Assessment of Treatment Response in Takayasu Arteritis
Authors: Olivier Caubet, Vincent Meunier, Roger Marthan, Eric Laffon
Journal: Clinical Nuclear Medicine (2016)

To describe a procedure allowing early assessment of treatment response in Takayasu arteritis (TA) patients by averaging the standard uptake value obtained from N hottest voxels irrespective of their location within the F-FDG-positive vessel walls (SUVmax-N).The procedure is illustrated in a score-V TA patient before and after 1 and 3 months of glucocorticoid treatment (scans 0-1-3, respectively). Comparison between scans was made by using SUVmax-N repeatability percentages with 95-99-99.9% reliability.No significant difference in SUVmax (ie, N = 1) was found between scan 0 and 1, and between scan 1 and 3, with 95% reliability. A significant difference in SUVmax-N was found with 99.9% reliability for each scan pair by averaging N = 4100-515 hottest voxels (total hottest volume of 100.0-12.6 mL), respectively.The proposed SUVmax-N procedure may be an efficient tool to early assess treatment response in TA patients. Further studies involving series of patients with large vessel vasculitis are warranted to investigate its usefulness in their management.
Major depression and the self-criticism and dependency personality dimensions
Authors: R M Bagby, D R Schuller, J D Parker, A Levitt, R T Joffe, M S Shafir
Journal: American Journal of Psychiatry (1994)

The Depressive Experiences Questionnaire was used to assess the personality dimensions of dependency and self-criticism in 52 depressed patients before and after treatment and in 22 healthy family practice patients. Neither personality dimension was significantly influenced by change in depressed mood, and the recovered depressed patients had higher levels of dependency and self-criticism than the comparison subjects.
Is Vertebral Augmentation the Right Choice for Cancer Patients With Painful Vertebral Compression Fractures?
Authors: Ioannis D Papanastassiou, Kamran Aghayev, James R Berenson, Meic H Schmidt, Frank D Vrionis
Journal: Journal of the National Comprehensive Cancer Network (2012)

Cancer-related fractures of the spine are different from osteoporotic ones, not only in pathogenesis but also in natural history and treatment. Higher class evidence now supports offering balloon kyphoplasty to a patient with cancer, provided that the pain is significant in intensity, has a positional character, and correlates to the area of the fractured vertebrae. Absence of clinical spinal cord compression and overt instability are paramount. Because of the frequent disruption of the posterior vertebral body cortex in these patients, the procedure should be performed by experienced operators who could also quickly perform an open decompression if cement extravasation occurs. Patients will benefit from vertebral augmentation, even in chronic malignant fractures. A biopsy should be routinely performed and a combination with radiation treatment would be beneficial in most cases.
SP0151 Observational Research Designs
Authors: L. Silva-Fernández
Journal: Annals of the Rheumatic Diseases (2015)

Observational studies are those studies where no intervention is carried out by the investigator. The researcher observes what happens to people under exposure conditions that have been determined by influences outside the control of the researcher. The main objective of observational studies is to determine prevalence, incidence, cause, prognosis or effect of treatment. The major problem in inferring causation in an observational study is that the exposed and unexposed groups may differ on other factors called confounders, that may themselves be causes of the outcome. The main analytical designs used in observational research are the cohort, cross-sectional and case-control studies. Observational studies are generally a cost-effective way of producing and investigating hypotheses before larger and more expensive study designs are carried out. Additionally, they are often the only realistic choice of research methodology. The STROBE statement provides guidance on how to report observational research well. <h3>Disclosure of Interest</h3> None declared
SP0209 Lessons from Coeliac Disease
Authors: F. Koning
Journal: Annals of the Rheumatic Diseases (2015)

Just like rheumatoid arthritis (RA), coeliac disease (CD) is an HLA-associated disease. In the case of CD the association is extraordinarily strong: close to 100% of patients are either HLA-DQ2 and/or HLA-DQ8 positive. CD is caused by pro-inflammatory T cell responses to gluten, proteins present in the cereals wheat, barley and rye. The resulting chronic inflammation in the upper small intestine leads to a variety of symptoms like stomach ache, malabsorption of nutrients, failure to grow and diarrhoea. Removal of gluten from the diet constitutes an effective treatment modality. Several amplification loops likely play a crucial role in the initiation and propagation of the gluten-specific T cell response. It has been established that native gluten peptides bind poorly to the disease predisposing HLA-DQ2 and HLA-DQ8 molecules while gluten peptides in which one or more glutamine residues are modified into glutamic acid bind with very high affinity. Such posttranslational modification of gluten is mediated by the enzyme tissue transglutaminase (TG2), which is released upon tissue damage. Thus, a critical step in CD pathogenesis is the occurrence of tissue damage, potentially as the result of an environmental insult, and the associated modification of gluten proteins generating an immunogenic repertoire of gluten-derived peptides. The IFNγ produced by the gluten-specific T cells can locally enhance HLA-DQ expression, facilitating the presentation of modified gluten peptides. A strongly biased, high affinity public T cell receptor (TCR) repertoire specific for immunodominant gluten peptides is observed in patients with CD, indicative of the stringent selection and expansion of T cells expressing such TCR. Structural studies have revealed the molecular basis for the interaction between such TCR and HLA-DQ-gluten. Next to T cells, antibodies specific for modified gluten are typically found in patients as well, providing yet another amplification loop as such antibodies can significantly enhance the uptake of modified gluten peptides and mediate effective B to T cell antigen presentation. There are striking similarities with RA. Next to the HLA-association, indicative for an involvement of T cells in the autoimmune process in RA as well, antibodies to enzymatically modified autoantigens (ACPA) are present in a subgroup of patients with RA. Strikingly, there is a very strong correlation between smoking and ACPA positive RA, pointing to a link between this environmental insult and the generation of ACPA. Finally, similar to in CD, ACPA could play a role in B to T cell presentation in RA and provide an amplification loop. Thus, the accumulated knowledge on CD pathogenesis is likely relevant to other HLA-associated immune diseases, including RA, and strongly suggests that a presently ill understood T cell response underlies the initiation of RA. <h3>Disclosure of Interest</h3> None declared
Abstract 3059: Impact of Complete Revascularization on Long-term Outcome after Percutaneous Coronary Intervention in the Bare Metal Stent Era: From the Coronary Revascularization Demonstrating Outcomes in Kyoto (CREDO-Kyoto)
Authors: Tamaki Suyama, Ryoji Taniguchi, Yoshisumi Haruna, Satoshi Shizuta, Toshihiro Tamura, Masanao Toma, Yutaka Furukawa, Natsuhiko Ehara, Hiroyuki Takashima, Minoru Horie, Ryuji Higashita, Tohru Asai, Makoto Araki, Kiyoshi Doyama, Yumika Fujino, Yukiko Imai, Satoshi Teramukai, Masanori Fukushima, Toru Kita, Takeshi Kimura
Journal: Circulation (2006)

Background: In the real world, complete revascularization of ischemic heart disease was difficult to definite and little was known its outcomes. This study was evaluated efficacy of complete revasc...
Low vaccine effectiveness against influenza A(H3N2) virus among elderly people in Denmark in 2012/13 – a rapid epidemiological and virological assessment
Authors: K Bragstad, H D Emborg, T K Fischer, M Voldstedlund, S Gubbels, B Andersen, K Mølbak, T G Krause
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Dog Pals
Authors: Therese M Zink
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Social competence and positive and negative symptoms: a longitudinal study of children and adolescents at risk for schizophrenia and affective disorder
Authors: R H Dworkin, G Bernstein, L M Kaplansky, J D Lipsitz, A Rinaldi, S L Slater, B A Cornblatt, L Erlenmeyer-Kimling
Journal: American Journal of Psychiatry (1991)

The authors longitudinally examined social competence and positive and negative symptoms in children at risk for schizophrenia, children at risk for affective disorder, and matched normal subjects.The subjects were offspring of parents with schizophrenia or affective disorder and normal comparison subjects matched on age, sex, and socioeconomic status. Ratings of social competence (Premorbid Adjustment Scale), affective flattening and poverty of speech (Scale for the Assessment of Negative Symptoms), and positive formal thought disorder (Scale for the Assessment of Positive Symptoms) were based on videotaped psychiatric interviews conducted in childhood (N = 144), early adolescence (N = 127), and adolescence (N = 106).In childhood, there were no significant group differences. In early adolescence, the subjects at risk for schizophrenia had poorer social competence than those at risk for affective disorder and the normal subjects. In early adolescence, the subjects at risk for schizophrenia also had greater positive thought disorder than those at risk for affective disorder but did not differ significantly from the normal subjects; there were no differences in negative symptoms. In adolescence, the subjects at risk for schizophrenia had poorer social competence and greater positive and negative symptoms than the adolescents at risk for affective disorder and the normal subjects.During early adolescence and adolescence, poor social competence may be more characteristic of children at risk for schizophrenia than those at risk for affective disorder. Higher levels of positive and negative symptoms may also be specific to subjects at risk for schizophrenia, but only during adolescence.
Preparation and characterization of spray-dried valsartan-loaded Eudragit® E PO solid dispersion microparticles
Authors: Roshan Pradhan, Sung Yub Kim, Chul Soon Yong, Jong Oh Kim
Journal: Asian Journal of Pharmaceutical Sciences (2016)

The purpose of this study was to develop the immediate release stomach-specific spray-dried formulation of valsartan (VAL) using Eudragit® E PO (EPO) as the carrier for enhancing dissolution rate in a gastric environment. Enhanced solubility and dissolution in gastric pH was achieved by formulating the solid dispersion using a spray drying technique. Different combinations of drug–polymer–surfactant were dissolved in 10% ethanol solution and spray-dried in order to obtain solid dispersion microparticles. Use of the VAL–EPO solid dispersion microparticles resulted in significant improvement of the dissolution rate of the drug at pH 1.2 and pH 4.0, compared to the free drug powder and the commercial product. A hard gelatin capsule was filled with the VAL–EPO solid dispersion powder prior to the dissolution test. The increased dissolution of VAL from solid dispersion microparticles in gastric pH was attributed to the effect of EPO and most importantly the transformation of crystalline drugs to amorphous solid dispersion powder, which was clearly shown by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), and powder X-ray diffraction (P-XRD) studies. Thus, VAL, a potential antihypertensive drug in the form of a solid dispersion microparticulate powder, can be effectively delivered in the immediate release dosage form for stomach-specific drug delivery.
Counterpoint: Routine Anti-Bacterial Prophylaxis Is Not Indicated in Neutropenic Patients With Hematological Malignancies
Authors: Michael Kleinberg
Journal: Journal of the National Comprehensive Cancer Network (2004)

Preventing bacterial infections by prescribing prophylactic antibiotics is seen by many as an important strategy for decreasing infectious mortality in the most profoundly immunosuppressed patients with hematologic malignancies. Comparative studies show consistently that neutropenic patients treated with prophylactic fluoroquinolone antibiotics develop fewer bacteremias than patients treated with placebo or less-potent antibacterials. However, these same studies fail to show increased survival rates in fluoroquinolone-treated patients. This repeated observation is the basis for the continued controversy concerning universal antibacterial prophylaxis of neutropenic patients, namely, the inability to translate the observed reduction in culture-proven bacterial infections with prophylaxis into improved clinical outcomes. The answer to this controversy lies in the effectiveness of empiric antibacterial therapy in response to neutropenic fevers. Mortality from bacterial infections is 1% or less for patients enrolled in empiric treatment trials who do not receive prophylactic antibacterials. Therefore, routine fluoroquinolone prophylaxis offers essentially no potential survival benefit to neutropenic patients with hematologic malignancies. In fact, the increasing potential for fluoroquinolones to select for resistant bacterial pathogens should give pause to the practice of routine prophylaxis of neutropenic patients.
SAT0085 Study of Prognostic Factors Associated with Death from Pneumocystis Pneumonia Complicated by Collagen Diseases
Authors: R. Yanai, Y. Miwa, T. Kasama, N. Yajima, T. Isozaki, K. Wakabayashi, R. Takahashi, S. Isojima, H. Furuya, M. Saito
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Corticosteroids and immunosuppressant are now widely used as a treatment for collagen diseases, and complications of pneumocystis pneumonia (PCP) have become a problem. <h3>Objectives</h3> We study prognostic factors associated with death from PCP complicated by collagen diseases. <h3>Methods</h3> We conducted a retrospective analysis on the basis of the medical records of 38 patients with PCP complicated by collagen diseases. For background factors, age, gender, baseline diseases, medications at the time of hospital admission (dose of steroids, immunosuppressant), the presence of complications (respiratory diseases, diabetes, chronic kidney disease), smoking history, trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis were studied. For laboratory data, CBC (including lymphocyte count), serum LDH, albumin, creatinine, CRP, KL-6, SP-D, IgG level, IgA, IgM, (1,3)-β-D-glucan, arterial blood gas, and sputum PCP-DNA (tested by PCR) at the time of hospital admission were investigated. The eGFR was calculated using creatinine value, age, and gender. We also studied treatment methods after hospitalization (TMP-SMX use, change from TMP-SMX to pentamidine, pulsed-steroid therapy, intratracheal intubation, managing in ICU) and hospitalization period. <h3>Results</h3> In laboratory data, the group of non-survivors had a higher creatinine (0.88±0.38 mg/dl vs. 1.16±0.38, p=0.045), a lower albumin (3.13±0.50 g/dl vs. 2.71±0.38, p=0.031), a higher CRP (7.8±7.0 mg/dl vs. 18.9±8.8, p=0.014), a lower IgA (274±108 mg/dl vs. 174±54, p=0.013), a higher serum SP-D (173±106 vs. 285±285, p=0.047), and a lower PaO2/FiO2 (P/F) ratio (268±99 mmHg vs. 147±98, p=0.025). For sputum PCP (by PCR), all patients were positive in the group of non-survivors, but only 18 out of 31 survivors (58%) were positive. All patients in the group of non-survivors underwent pulsed-steroid therapy, but it was assumed that the therapy was performed in order to treat severe respiratory failure because the patients who resulted in death had a low P/F ratio and severely poor respiratory status. On the other hand, as background factors, there was no significant difference. <h3>Conclusions</h3> We newly identified prognostic factors associated with death from PCP, which are a low serum albumin and cholinesterase at the time of PCP diagnosis, decreased pulmonary diffusing capacity, and significantly high rate of intratracheal intubation and managing in ICU; in this study, male, older age, a high serum creatinine, a high CRP, a low IgA, a high SP-D, a low P/F ratio, and sputum PCP positive (by PCR) were newly identified as the poor prognostic factors. <h3>Disclosure of Interest</h3> None declared
Bone Loss and Bone Size after Menopause
Authors: Ala M Mohamed
Journal: New England Journal of Medicine (2003)

Bone loss increases after menopause.However, bone strength also depends on structural characteristics such as bone size.Whether bone size increases as a result of periosteal apposition and whether a strength index accounting for both bone density and bone size might predict the risk of fracture better than bone density alone are unclear.methods Bone mass and the skeletal structure of the distal radius were evaluated by single-photon absorptiometry every other year in 108 women, all of whom were followed from the time of menopause for a mean period of 15 years.Postmenopausal serum estradiol levels and fractures of the distal radius were noted.
AB0004 Characterization of Putative Pre-RA Signatures by Transcriptome Analysis
Authors: E. Petit-Teixeira, C. Derbois, C. Dalmasso, R. Olaso, C. Ambroise, M.S. Ben Kilani, J.-F. Deleuze, C. Gabay, F. Cornelis, A. Finckh
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Currently, the general understanding of the RA development is that the RA biological initiation precedes the clinical onset of the disease by up to several years. To identify new risk factors and pre-RA biomarkers that would detect specific disease development of pre-clinical phases and eventually predict disease onset and outcome, sampling in new large cohorts of asymptomatic individuals was initiated. Characterization of such individuals at high risk of developing RA will provide helpful strategies for early preventive treatment of RA. <h3>Objectives</h3> Benefiting of such a cohort collected in Switzerland, we aimed to characterize whole expression profile using blood samples from healthy first degree relatives of RA. A differential expression study was performed after stratification regarding clinical symptoms onset during follow-up. <h3>Methods</h3> Whole transcriptome analysis was performed with Illumina <i>HumanHT-12 v4 Expression</i> BeadChip using RNAs extracted from blood samples of 69 healthy first degree RA relatives. During the follow-up, 15 out of 69 became symptomatic with at least one swollen or tender joint. After differential expression analysis, bioinformatics tools were used to identify pathways and/or biological process enrichment. <h3>Results</h3> Controlling the false discovery rate at 0.5 level to optimize detection of putative signatures, we identified a list of 201 differentially expressed genes. Several pathways and biological process have been highlighted through this gene list. <h3>Conclusions</h3> This preliminary study provides candidate gene expression signatures which could be relevant for the development of RA. These candidate signatures have to be tested for their RA predictive value in a new sample set from first degree RA relatives from a French similar cohort and molecular validation of genes differentially expressed has to be performed. Follow-up of individuals will allow stratification of symptomatic relatives considering rheumatoid arthritis development, to refine expression signatures. <h3>Disclosure of Interest</h3> None declared