tbuckley/cabot-search huggingface dataset:
What Journals for the Physicians?
Authors: E J Huth
Journal: Annals of Internal Medicine (1976)

Editorial Notes1 November 1976What Journals for the Physicians?Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-5-674 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail AbstractAbstractOnly a naive editor could think of clinical journals as the first sources of information in the day-to-day work of the busy clinician. But journals do meet some needs; thousands of physicians voluntarily subscribe to The Lancet, The New England Journal of Medicine, this journal, and others. The needs served are diverse—new information, new concepts, reviews of treatment or diagnostic methods, didactic exercises such as the clinicopathologic conference, an outlook onto the society and culture of medicine, even professional gossip. But whatever the busy clinician's particular needs, he or she has little time for reading or even for scanning; journals must be chosen carefully. The choice is difficult for the clinician who wants to keep informed both widely and well. Papers and articles pertinent to clinical medicine are divided among scores and scores of journals, some broad in scope but most highly specialized. How many journals and what journals should the internist follow closely?The paper in this issue (p. 686) by Dr. Oster looks at one aspect of this problem. He has analyzed the coverage of clinical oncology in three broad-scope journals andReference1. GARFIELD E (editor and compiler): Journal Citation Reports. A Bibliometric Analysis of References Processed for the 1974 Science Citation Index, vol. 9, Science Citation Index, 1975 Annual. Philadelphia, Institute for Scientific Information, 1976 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLoose Connections between Peer-Reviewed Clinical Journals and Clinical PracticeR. Brian Haynes, MD, PhDAn Information System for the Future?A Toast to the AnnalsW. B. SPAULDING, M.D., F.R.C.P.(C), F.A.C.P. 1 November 1976Volume 85, Issue 5Page: 674-675KeywordsDiagnostic medicineExercise ePublished: 1 December 2008 Issue Published: 1 November 1976 PDF downloadLoading ...
LG-53MicroRNA519d AND microRNA4758 IN DISTINGUISHING GANGLIOGLIOMA FROM DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS AND ASTROCYTOMAS
Authors: Avanita Prabowo, Andrea Arena, Jasper Anink, Wim Spliet, Antoinette Schouten-van Meeteren, Anand Iyer, Eleonora Aronica
Journal: Neuro-Oncology (2016)
Assessment of absolute lymphocyte count (ALC) as a predictor of progression-free survival (PFS) and overall response rate (ORR) in metastatic melanoma (MM) patients (pts) treated with high-dose interleukin-2 (HD IL-2).
Authors: Jeffrey Thomas Yorio, Patricia S Fox, Richard Wayne Joseph, Roland Bassett, Michael A. Davies
Journal: Journal of Clinical Oncology (2013)

9096 Background: HD IL-2 is an approved immunotherapy that can achieve durable cures in MM pts. Due to toxicity and low ORR, identification of predictors of clinical benefit would enhance pt selection and outcomes with HD IL-2. Recent research identified a positive correlation for ALC ≥ 1000 (either at baseline or at dose 3) with OS among MM pts treated with the immunotherapy agent ipilimumab. We tested the hypothesis that ALC (≥ 1000) or other hematological parameters correlates with clinical benefit from HD IL2. Methods: Results of hematologic testing in patients (n=98) treated with HD IL2 at MD Anderson Cancer Center were collected, including absolute levels of neutrophils (ANC), lymphocytes (ALC), monocytes (AMC), eosinophils (AEC), and platelets (APC) at baseline, after cycle 1 (C1), and after cycle 2 (C2) of HD IL-2; changes in each parameter for each interval were also calculated. Hematologic values were assessed as categorical (for ALC, ≥ 1000 Yes/No; other parameters, above upper limit of normal [ULN] Yes/No) and continuous variables. Associations between these parameters and PFS and ORR were analyzed. Results: ALC was≥ 1000 in 75 pts (76%) at baseline, in 81 (83%) after C1, and in 80 of 86 pts (93%) after completion of C2 of HD IL-2. PFS was not significantly associated with ALC ≥ 1000 at baseline (HR 0.69, p=0.13), after C1 (HR 1.32, p=0.33), or after C2 (HR 1.01, p=0.98). ALC ≥ 1000 at each timepoint was not significantly associated with ORR or OS. There was no significant difference in the change in ALC with HD IL2 treatment among responders versus non-responders. Among baseline hematological factors, APC &gt; ULN was significantly associated with PFS (p=0.001), but it was rare (2/98 patients). Exploratory analyses identified significantly shorter PFS for patients with baseline APC &gt; 300 (11%, HR 2.75, p=0.002). Analysis of hematologic factors as continuous values identified significant associations with PFS for AMC (HR 2.42, p=0.03) and AEC (HR 1.73, p=0.009) after C2. Conclusions: ALC ≥ 1000 did not correlate with PFS, ORR, or OS with HD IL-2 therapy in this cohort of metastatic melanoma pts.
Diagnosis of cholelithiasis
Authors: V HOFFMANN
Journal: JAMA (1984)

<h3>To the Editor.—</h3> In the article entitled "Endoscopic Retrograde Cholangiopancreatography" (1983;249:758), Venu and co-workers contend that those patients with symptoms suggestive of cholelithiasis and abnormal liver function test results should have an endoscopic retrograde cholangiopancreatography (ERCP) examination despite normal oral cholecystogram and sonograms of the gallbladder. This study was based on a retrospective analysis of patients examined between 1975 and 1980. Of the 206 patients examined, only 30 had real-time ultrasonography. Of these, three patients, or 10%, had false-negative results. A 10% false-negative rate with real-time ultrasound is no longer an acceptable figure. It is interesting that of the 29 patients who did have gallstones at ERCP or cholecystectomy, only three were missed by real-time ultrasound, leaving the other 26 false-negative results caused by either oral cholecystography or static sonography. I agree with the results of Cooperberg and Burhenne<sup>1</sup>recording a specificity of about 95% in the diagnosis of
Identification of a subgroup of tardive dyskinesia patients by pharmacologic probes
Authors: D C Moore, M B Bowers
Journal: American Journal of Psychiatry (1980)

Some patients with tardive dyskinesia fit the cholinergic-dopaminergic imbalance theory, but some do not. In an attempt to study his heterogeneity further, the authors measured the responses of 10 patients with tardive dyskinesia to intravenous challenge doses of drugs that facilitate or inhibit acetylcholine transmission (physostigmine or benztropine, respectively). They then measured the response of these patients to an open outpatient deanol trial. They found that the responses of half of the patients followed the classic theory, 2 responded paradoxically, and 3 responsed inconsistently. They suggest that there is a subgroup of tardive dyskinesia patients who fit the theory but that more research is needed to identify the subgroups who do not.
IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection
Authors: Kristin R. Renkema, June-Yong Lee, You Jeong Lee, Sara E. Hamilton, Kristin A. Hogquist, Stephen C. Jameson
Journal: The Journal of Experimental Medicine (2016)

Previous studies have revealed that a population of innate memory CD8+ T cells is generated in response to IL-4, first appearing in the thymus and bearing high expression levels of Eomesodermin (Eomes) but not T-bet. However, the antigen specificity and functional properties of these cells is poorly defined. In this study, we show that IL-4 regulates not only the frequency and function of innate memory CD8+ T cells, but also regulates Eomes expression levels and functional reactivity of naive CD8+ T cells. Lack of IL-4 responsiveness attenuates the capacity of CD8+ T cells to mount a robust response to lymphocytic choriomeningitis virus infection, with both quantitative and qualitative effects on effector and memory antigen-specific CD8+ T cells. Unexpectedly, we found that, although numerically rare, memory phenotype CD8+ T cells in IL-4Rα–deficient mice exhibited enhanced reactivity after in vitro and in vivo stimulation. Importantly, our data revealed that these effects of IL-4 exposure occur before, not during, infection. Together, these data show that IL-4 influences the entire peripheral CD8+ T cell pool, influencing expression of T-box transcription factors, functional reactivity, and the capacity to respond to infection. These findings indicate that IL-4, a canonical Th2 cell cytokine, can sometimes promote rather than impair Th1 cell–type immune responses.
QOS-43A TWO-YEAR FOLLOW-UP STUDY OF NEUROCOGNITION IN CHILDREN TREATED FOR A BRAIN TUMOR
Authors: Jurgen Lemiere, Lise Thijs, Linde Van den Wyngaert, Trui Vercruysse, Charlotte Sleurs, Monique Haers, Karen Vandenabeele, Sandra Jacobs
Journal: Neuro-Oncology (2016)
Adults Eligible for Cardiovascular Disease Prevention Counseling and Participation in Aerobic Physical Activity — United States, 2013
Authors: John D. Omura, Susan A. Carlson, Prabasaj Paul, Kathleen B. Watson, Fleetwood Loustalot, Jennifer L. Foltz, Janet E. Fulton
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Cardiovascular disease (CVD) is the leading cause of death in the United States, and physical inactivity is a major risk factor (1). Health care professionals have a role in counseling patients about physical activity for CVD prevention. In August 2014, the U.S. Preventive Services Task Force (USPSTF) recommended that adults who are overweight or obese and have additional CVD risk factors be offered or referred to intensive behavioral counseling interventions to promote a healthful diet and physical activity for CVD prevention. Although the USPSTF recommendation does not specify an amount of physical activity, the 2008 Physical Activity Guidelines for Americans state that for substantial health benefits adults should achieve ≥150 minutes per week of moderate-intensity aerobic physical activity or ≥75 minutes per week of vigorous-intensity aerobic activity, or an equivalent combination of moderate- and vigorous-intensity aerobic physical activity. To assess the proportion of adults eligible for intensive behavioral counseling and not meeting the aerobic physical activity guideline, CDC analyzed data from the 2013 Behavioral Risk Factor Surveillance System (BRFSS). This analysis indicated that 36.8% of adults were eligible for intensive behavioral counseling for CVD prevention. Among U.S. states and the District of Columbia (DC), the prevalence of eligible adults ranged from 29.0% to 44.6%. Nationwide, 19.9% of all adults were eligible and did not meet the aerobic physical activity guideline. These data can inform the planning and implementation of health care interventions for CVD prevention that are based on physical activity.
LG-02MYB-QKI REARRANGEMENTS IN ANGIOCENTRIC GLIOMA DRIVE TUMORIGENICITY THROUGH A TRIPARTITE MECHANISM
Authors: Guillaume Bergthold, Pratiti Bandopadhayay, Lori Ramkissoon, Payal Jain, Jeremiah Wala, Steven Schumacher, Shakti Ramkissoon, Pascale Varlet, Mélanie Pages, Matthew Ducar, Paul Van Hummelen, Daniel Bowers, Caterina Giannini, Stephanie Puget, Cynthia Hawkins, Uri Tabori, Almos Klekner, Laszlo Bognar, Peter Burger, Charles Eberhart, Fausto Rodriguez, D. Ashley Hill, Sabine Muller, Daphne Haas-Kogan, Joanna Phillips, Sandro Santagata, Charles Stiles, James Bradner, Nada Jabado, Alon Goren, Jacques Grill, Azra Ligon, Liliana Goumnerova, Angela Waanders, Philip Storm, Mark Kieran, Adam Resnick, Keith Ligon, Rameen Beroukhim
Journal: Neuro-Oncology (2016)
CPR-Not-Indicated and Futility
Authors: Jonathan P. Katz
Journal: Annals of Internal Medicine (1996)

Letters1 January 1996CPR-Not-Indicated and FutilityJonathan P. Katz, MDJonathan P. Katz, MDUniversity of Pennsylvania Medical Center; Philadelphia, PA 19104Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-1_Part_1-199601010-00030 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:In their assessment of CPR-not-indicated proposals, Waisel and Truog [1] conclude that “policies based on anything other than physiologic futility are indefensible,” adding that physiologic futility “is a symbolic statement” that “does little to advance current practice management.” For the house officer, such conclusions have little value. As the person who must carry out the word of any directives, the house officer is often caught in the middle of decisions on resuscitation.Physiologic futility as a guideline for CPR-not-indicated policies has several drawbacks. First, physiologic futility is difficult to assess before implementing resuscitative measures. Second, when the ...REFERENCE1. Waisel DB, Truog RD. The cardiopulmonary resuscitation-not-indicated order: futility revisited. Ann Intern Med. 1995; 122:304-8. Google Scholar Author, Article, and Disclosure InformationAuthors: Jonathan P. Katz, MDAffiliations: University of Pennsylvania Medical Center; Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byControversial issues in critical care for the elderly: a perspective from Canada 1 January 1996Volume 124, Issue 1_Part_1Page: 77KeywordsDecision analysisDecision makingDo not resuscitate ordersIntensive care unitsResuscitation ePublished: 15 August 2000 Issue Published: 1 January 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
HG-99A PATIENT-DERIVED PAEDIATRIC HIGH GRADE GLIOMA AND DIPG CELL CULTURE PANEL RECAPITULATING THE GENOTYPIC AND PHENOTYPIC DIVERSITY OF THE DISEASE
Authors: Mara Vinci, Valeria Molinari, Kathryn Taylor, Diana Carvalho, Anna Burford, Alan Mackay, Sergey Popov, Mariama Fofama, Janat Fazal-Salom, Lynn Bjerke, Jessica K.R. Boult, Helen Pemberton, Christopher J. Lord, Louise Howell, Jane Pears, Angela Mastronuzzi, Andrea Carai, Lynley V. Marshall, Stergios Zacharoulis, Sucheta Vaidya, Henry C. Mandeville, Leslie R. Bridges, Andrew J. Martin, Safa Al-Sarraj, Christopher Chandler, Simon P. Robinson, Nagore G. Olaciregui, Mariona Sunol, Jaume Mora, Carmen de Torres, Ofelia Cruz, Michelle Monje, Andrew S. Moore, Angel M. Carcaboso, Chris Jones
Journal: Neuro-Oncology (2016)
Soundings: Happy forms?
Authors: Trisha Greenhalgh
Journal: BMJ (2000)

I went to a conference recently and found it decidedly hard going. The programme was ominously crammed with one eminent speaker after another. Coffee breaks were repeatedly truncated while the chairman distributed a set of yellow forms on which we were asked to rank each talk in terms of content, relevance, interest, delivery, and handouts, each on a five point scale from poor to excellent. I gave middling to positive responses, since the suits on the podium had clearly worked hard on their offerings and could hardly be blamed for the overpacked timetable, the slack chairing, or the failure of the air conditioning system on the hottest day of the year.

Later, again as an encroachment into the refreshment break (and with instructions to complete them before resuming the programme), we were issued with blue forms asking us to reflect on our overall learning experience thus far. On the second day, we were served with more yellow forms, followed by more blue forms, followed a few hours later by a white form in which we were invited to reflect on the previous day's reflection exercise and say whether we had found it helpful in preparing us for day two.

Don't get me wrong. I am fully signed up to the evaluation agenda. Contracts to evaluate various educational initiatives pay a sizeable fraction of my own salary. But the perceived need to continually evaluate our attempts at evaluation and reflect on our reflections at every interpersonal encounter from the car park committee to the undergraduate tutorial reminds me of a sadomasochistic patient who requested to remain awake during his colonoscopy and spent an ecstatic two hours gazing painfully up his own backside.

When the conference organisers have finished collating the responses on their yellow, blue, and white forms, I suspect they will have learnt three fundamental lessons. Firstly, distributing evaluation forms is like pulling out a video camera—it fundamentally alters the nature of the event you are attempting to capture, and, if overused, the process threatens to destroy the “real” experience altogether. Secondly, the most helpful feedback is almost invariably to be found in the free text responses to questions such as “Are there any other comments you would like to make?” And finally, if you insist on asking vast numbers of closed questions, you will still be analysing your data long after you ceased to care about the answers.
Short-term treatment of Sexual problems: interim report
Authors: J K Meyer, C W Schmidt, M J Lucas, E Smith
Journal: American Journal of Psychiatry (1975)

Of 52 couples requesting treatment for sexual disorders, 16 were treated in accordance with the protocol of Masters and Johnson except that most were seen once a week for 10 or more weeks rather than daily for a briefer period. The treatment results were less successful than those obtained by Masters and Johnson. The authors believe that the successes of this approach nonetheless suggest a need to reevaluate the degree to which sexual problems may be conditioned responses. They also stress the need for specifying the degree of improvement among nonfailures for purposes of comparison and follow-up.
Doctors urge public health led approach to drugs policy
Authors: Anne Gulland
Journal: BMJ (2016)

Public health doctors have called for an end to the criminalisation of drug possession and personal drug use.

In a report the Royal Society for Public Health, supported by the Faculty of Public Health,1 called for a move away from the “war on drugs” approach, towards harm reduction and public health led policies. It said that the recent United Nations General Assembly meeting on global drug use was a “missed opportunity” to pursue such policies.2

Although the report acknowledged that drug use has fallen over the last decade there has been an increase in the use of class A drugs, such as heroin. Self reported drug use among 16 to …
Medicaid cutbacks and block grants: crisis or opportunity for community mental health?
Authors: S S Sharfstein
Journal: American Journal of Psychiatry (1982)

The fourfold growth in the mental health service system since 1955 has been largely financed by federal monies and by federal and state funding through Medicaid. This growth represents expansion of both institutional and outpatient settings, even though there has been a total reversal of the proportion of inpatient to outpatient care over the last 22 years. Current proposals to cap Medicaid costs and to issue block grants challenge the delivery system to attempt alternatives, such as financing similar to what is done in a health maintenance organization (HMO). The author describes a model of a "mental health HMO" that would be appropriate from professional consumer, and economic perspectives.
Vaccination campaign for meningococcal disease in a rural area in the Netherlands - January 1998
Authors: J. E. van Steenbergen, A. G. Kraayeveld, L Spanjaard
Journal: Eurosurveillance (1999)

Neisseria meningitidis group C regularly causes epidemics in schools, universities, and army units, and in the past decade community outbreaks have been reported. Since a safe and effective polysaccharide vaccine is available the issue arises repeatedly
Segregation Mammary Cancer to No Mammary Cancer in the Marsh Albino Strain of Mice
Authors: W. S. Murray, Sc. D., S. G. Warner, M. A.
Journal: JNCI Journal of the National Cancer Institute (1947)

Segregation Mammary Cancer to No Mammary Cancer in the Marsh Albino Strain of Mice Get access W. S. Murray, Sc. D., W. S. Murray, Sc. D. Roswell Park Memorial Institute, Buffalo Search for other works by this author on: Oxford Academic PubMed Google Scholar S. G. Warner, M. A. S. G. Warner, M. A. Roswell Park Memorial Institute, Buffalo Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 4, February 1947, Pages 183–188, https://doi.org/10.1093/jnci/7.4.183 Published: 01 February 1947 Article history Received: 14 November 1946 Published: 01 February 1947
Angiotensin System Inhibitors in Renal Cell Carcinoma—Letter
Authors: Olivier Huillard, Evanguelos Xylinas, Michael Peyromaure, Jerome Alexandre, Francois Goldwasser
Journal: Clinical Cancer Research (2016)

We read with interest the article by McKay and colleagues ([1][1]) evaluating the impact of angiotensin system inhibitors (ASI) on outcomes in metastatic renal cell carcinoma (mRCC) patients treated in the targeted therapy era. They found that ASI users had improved overall survival (OS) compared
Integrated Screening for Down's Syndrome
Authors: T M Jenkins, R J Wapner
Journal: New England Journal of Medicine (1999)

Coronary Artery Disease in Men and WomenTo the Editor: Vaccarino et al. (July 22 issue) 1 show that younger women, but not older women, have higher rates of death during hospitalization after acute myocardial infarction than men of the same age.Potential reasons for their findings include differences between men and women with respect to the aggressiveness of the disease, the treatment strategies used, and rates of death before hospitalization.Studies from the World Health Organization's Monitoring Trends and Determinants in Cardiovascular Disease (MONICA) project have shown that a higher rate of death from acute myocardial infarction during hospitalization among women may be balanced by a higher rate of National Board of Health and Welfare S-106 30 Stockholm, Sweden N IKLAS H AMMAR , P H .
Talc Retinopathy
Authors: Scott D Schoenberger, Anita Agarwal
Journal: New England Journal of Medicine (2013)

A 56-year-old woman who had undergone bilateral lung transplantation for COPD was found to have fine crystals in the inner retinal layer in the maculae of both eyes, although she was asymptomatic. A remote history of long-term IV drug use was confirmed.
Dissociation: the clinical realities
Authors: F H Frankel
Journal: American Journal of Psychiatry (1996)

An attempt was made by the authors of DSM-III to restrict its focus to the experimental, the observable, and the measurable. The intention was to free the nosology from the influence of unproven theories, and the philosophy was driven largely by the importance of research being able to identify diagnostic categories to facilitate the study of homogeneous groups. So it is of interest that the authors accepted dissociation-an ambiguous event linked to an explicit theoretical concept that had been introduced by Janet-as the basis for classification of clinical presentations that were formerly included under the rubric of hysteria, a similarly unclear category. Since DSM-III, there have been an increasing number of reports of dissociative experiences and dissociative identity disorder (formerly known as multiple personality disorder), but neither of these clinical presentations seems able to withstand the concern that it is dramatically influenced by environmental cues, e.g., the expectations of the therapist. Thus, a restricted phenomenological perspective does not fully appreciate the distorting potential of suggestibility and imagination on the nature of the emerging clinical picture. These factors might well have contributed to and laid the conceptual groundwork for the growth in the number of reports of dissociation.