tbuckley/cabot-search huggingface dataset:
FRI0525 Elastographic Ultrasound of Metacarpophalangeal (MCP) Synovium in Rheumatoid Arthritis (RA)
Authors: A.M. Sammel, M.C. Spies, R. DeCarle, M. Rayment, F. Joshua
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Shear wave elastographic ultrasound (SW-EUS) assesses the stiffness of human tissues. It is used in liver, thyroid and breast imaging but has never before been studied in synovium. Soft tissues have a slower shear wave velocity (SWV) than stiff tissues. We hypothesised that rheumatoid arthritis (RA) patients would have softer synovium and thus slower SWV than controls. <h3>Objectives</h3> The aim of the project was to establish a reproducible scoring system for synovial SW-EUS and use it to compare RA patients with controls. We also set out to assess if SWV varied with disease activity. <h3>Methods</h3> A cross sectional study was conducted including nine RA patients and five age and sex matched controls. RA patients were recruited consecutively from a single rheumatology practice. Participants underwent a questionnaire, clinical examination, blood sampling, grey scale ultrasound (GSUS), power doppler ultrasound and SW-EUS ultrasound examination of MCP joints 2 - 5 on the dominant hand. Ultrasound was performed and scored by two blinded musculoskeletal trained sonographers. <h3>Results</h3> The average age of participants was 60. The mean RA disease activity score (DAS28-ESR) was in the low to moderate range of 3.65 (range 2.4–7.4). Patients with RA had significantly lower maximum SWV than controls (6.38 m/s vs 6.99 m/s p=0.042). Negative Pearson9s correlation coefficients (PCC) were observed between maximum SWV and a range of disease activity markers including GSUS graded synovial thickness (PCC = -0.57, p=0.03) and ESR (PCC = -0.46, p=0.095). SW-EUS had good intra- and inter-observer reliability with intraclass correlation coefficients of 0.66 and 0.58 for maximum SWV and &gt;0.80 for colour scale rated average and minimum SWV. <h3>Conclusions</h3> This is the first reported study of SW-EUS in synovial tissue. Maximum SWV was significantly lower in the synovium of RA patients compared with controls. There was a negative correlation between maximum SWV and GSUS graded synovial thickening suggesting that SWV may be lower in more active patients. SW-EUS may have a role in the diagnosis and assessment of disease activity in RA. <h3>Disclosure of Interest</h3> None declared
AB0622 Assessment of Ouality of Life in Systemic Sclerosis Patient with Translation, Cross-Cultural Adaptation, and Validation of The Systemic Sclerosis Questionnaire (SySQ) into The Turkish Language
Authors: F. Temiz, M. Saganak, N. Enginar, G. Ozen, A.U. Unal, Y. Sahinkaya, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic Sclerosis (SSc) is a multisystem connective tissue disorder which decreases the life-expectancy and quality of life (QoL) of the patients. <h3>Objectives</h3> To determine the effects of SSc on physical and mental health of the patients as well as their QoL and translation, cross-cultural adaptation, and validation of the Systemic Sclerosis Questionnaire (SySQ) to the Turkish language. <h3>Methods</h3> We evaluated 88 SSc patients (F/M=77/11, mean age 49.8±12.4 and mean disease duration 7.2±6.0 years, limited/diffuse=60/28) and 81 healthy subjects (HS)(F/M=70/11, mean age 46.8±11.2 years) without a history of malignancy and infection. QoL, functional capacity, fatique, anxiety and depression were assessed by SF-36, SySQ, HAQ, UK SSc functional score (UKFS), FACIT-F and HADS, respectively. The SySQ was translated according to international guidelines and administered to all patients and controls. Internal consistency was tested by computing Cronbach9s alpha. Test-retest reliability was determined by computing the intraclass correlation coefficient (ICC). Correlation of SySQ with SF-36, HADS, FACIT-F was assessed by using Pearson test. <h3>Results</h3> The internal consistency of SySQ was similar to the original study (1) and ranged from 0.812–0.937 for items. The interobserver reliability was also very good for each item (ICC: 0.88–0.97). QoL assessed by SySQ, anxiety and depression and fatique scores were significantly worse in SSc patients than healthy subjects (Table 1). All items of SySQ positively correlated with UKFS, HAQ, HADS scores, patient and physician global assessments of disease activity and negatively correlated with all parameters of SF-36 and FACIT-FT. <h3>Conclusions</h3> Disease-specific QoL, mental and physical health of the SSc patients were significantly worse than healthy individuals in our study. Turkish version of SySQ is reproducible and valid for Turkish SSc patients. Fatma Temiz, Merve Saganak, Nazife Enginar and Gulsen Ozen contributed equally to this research. <h3>References</h3> Ruof J, Brühlmann P, Michel BA, Stucki G. Development and validation of a self-administered systemic sclerosis questionnaire (SySQ). Rheumatol. 1999;38:535–42. <h3>Disclosure of Interest</h3> None declared
THU0064 Short and Sustained Periods of ACR/EULAR Remission Predict Good Functional Outcome, but Not Stable Radiographic Outcome in Early Rheumatoid Arthritis
Authors: N. Konijn, L. van Tuyl, M. Boers, D. Den Uijl, M. ter Wee, P. Kerstens, A. Voskuyl, D. van Schaardenburg, M. Nurmohamed, W. Lems
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The ACR/EULAR remission criteria were validated against their potential to predict future prognosis of rheumatoid arthritis (RA) [1]. Sustained remission was not studied, but is likely to be an even stronger predictor of RA prognosis. Furthermore, the patients in the validation study mainly had established RA, whereas results might be different for early RA patients. <h3>Objectives</h3> To investigate whether remission at single and consecutive visits predicts good outcome in early RA. <h3>Methods</h3> The presence of remission according to ACR/EULAR and other criteria (Boolean clinical, CDAI, DAS, DAS28, RAPID3) was assessed in early RA patients during the first year of the COBRA-light trial [2,3]. Likelihood ratios were used to assess whether meeting the remission criteria at single visits (13, 26, 39 or 52 weeks) and consecutive visits (13+26, 26+39 or 39+52 weeks) predicted good outcome in the second year (52–104 weeks). Good outcome was defined for function (HAQ consistently ≤0.5 and no deterioration), radiographic damage progression (no deterioration in Sharp-Van der Heijde scores) and both ("overall good outcome"). <h3>Results</h3> Of the original 164 trial patients, 144 had evaluable data. In the second year, good functional outcome was observed in 35%, good radiographic outcome in 79%, and both in 28% of the patients. Highest sustained remission rates at 13+26, 26+39, and 39+52 weeks were observed for DAS28, followed by DAS, SDAI, CDAI, RAPID3, Boolean clinical and Boolean criteria (Figure 1). Almost all criteria predicted good functional and good overall outcome, at both single and consecutive visits; only single DAS remission did not significantly predict good overall outcome (p=0.07). Sustained remission periods resulted in higher likelihood ratios than remission at single visits (Table 1). None of the criteria predicted good radiographic outcome. <h3>Conclusions</h3> Early RA patients who reach remission according to ACR/EULAR and other criteria during short or sustained periods are likely to retain good physical function in the subsequent months. Sustained remission periods are a stronger predictor than remission at single visits. However, in the setting of low overall damage progression, (sustained) remission was not predictive of good radiographic outcome. <h3>References</h3> Felson, Arthritis Rheum 2011; Den Uyl, ARD 2014; Ter Wee, ARD 2015. <h3>Disclosure of Interest</h3> N. Konijn: None declared, L. van Tuyl: None declared, M. Boers Consultant for: MundiPharma, Pfizer, D. Den Uijl: None declared, M. ter Wee: None declared, P. Kerstens: None declared, A. Voskuyl: None declared, D. van Schaardenburg: None declared, M. Nurmohamed: None declared, W. Lems Grant/research support from: This study was supported by an unrestricted grant from Pfizer
Pharmacokinetics of Dasatinib as a First Line Therapy In Newly Diagnosed CML Patients (OPTIM dasatinib trial): Correlation with Safety and Response.
Authors: Philippe Rousselot, Stéphane Boucher, Gabriel Etienne, Franck E Nicolini, Emmanuelle Chauzit, Pascale Cony Makhoul, Valérie Coiteux, Agnès Guerci, Martine Gardembas, Laurence Legros, Lydia Roy, Caroline Dartigeas, Maud Janvier, Christian Berthou, Lambert Busque, Mathieu Molimard, Joelle Guilhot, Luigina Mollica, Francois-Xavier Mahon
Journal: Blood (2010)
Impaired NK Cells Cytotoxicity Against Activated, Alloreactive Donor T Cells in aGVHD and Ability of Dasatnib to Restored the Gvhd-Regulation Function of NK Cells
Authors: Lixia Sheng, Huarui Fu, Yongxian Hu, Shan Fu, Yamin Tan, Yi Luo, Xiaoyu Lai, Jimin Shi, Ying He, He Huang
Journal: Blood (2014)
A Randomized, Double Blind, Placebo-Controlled, Cross-over Study to Evaluate the Haemostatic Effects of Three Commonly Used Traditional Herbal Medicines, (Curcuma Longa, Angelicae Sinensis and Panax Ginseng)and Their Interactions with Aspirin
Authors: Lai Heng Lee, Chuen Wen Tan, Wan Hui Wong, Foon yin Fung, Hwee Ling Koh, Yan Zhao, Mei Ching Kun, Xiao Mei Li, Heng Joo Ng, Seng Kok Ang, Yeh Ching Linn
Journal: Blood (2015)
Aggregate penetrance of genomic variants for actionable disorders in European and African Americans
Authors: Pradeep Natarajan, Nina B. Gold, Alexander G. Bick, Heather McLaughlin, Peter Kraft, Heidi L. Rehm, Gina M. Peloso, James G. Wilson, Adolfo Correa, Jonathan G. Seidman, Christine E. Seidman, Sekar Kathiresan, Robert C. Green
Journal: Science Translational Medicine (2016)

In populations that have not been selected for family history of disease, it is unclear how commonly pathogenic variants (PVs) in disease-associated genes for rare Mendelian conditions are found and how often they are associated with clinical features of these conditions. We conducted independent, prospective analyses of participants in two community-based epidemiological studies to test the hypothesis that persons carrying PVs in any of 56 genes that lead to 24 dominantly inherited, actionable conditions are more likely to exhibit the clinical features of the corresponding diseases than those without PVs. Among 462 European American Framingham Heart Study (FHS) and 3223 African-American Jackson Heart Study (JHS) participants who were exome-sequenced, we identified and classified 642 and 4429 unique variants, respectively, in these 56 genes while blinded to clinical data. In the same participants, we ascertained related clinical features from the participants' clinical history of cancer and most recent echocardiograms, electrocardiograms, and lipid measurements, without knowledge of variant classification. PVs were found in 5 FHS (1.1%) and 31 JHS (1.0%) participants. Carriers of PVs were more likely than expected, on the basis of incidence in noncarriers, to have related clinical features in both FHS (80.0% versus 12.4%) and JHS (26.9% versus 5.4%), yielding standardized incidence ratios of 6.4 [95% confidence interval (CI), 1.7 to 16.5; P = 7 × 10-4) in FHS and 4.7 (95% CI, 1.9 to 9.7; P = 3 × 10-4) in JHS. Individuals unselected for family history who carry PVs in 56 genes for actionable conditions have an increased aggregated risk of developing clinical features associated with the corresponding diseases.
AB0067 Autotaxin Involvement in Osteoclast Differentiation and Function
Authors: S. Flammier, T. Gicquel, F. Duboeuf, O. Peyruchaud, I. Machuca-Gayet, F. Coury
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Autotaxin (ATX) is a secreted protein produced by various tissues in the body including the liver, adipose tissue and bone. Autotaxin (ATX) is an enzyme with a phospholipase D activity responsible for cleavage of lysophosphatidyl-choline (LPC) in lysophosphatidic acid (LPA). LPA is a bio phospholipid, which acts as a growth factor, affecting proliferation, differentiation, and migration. It has been shown that the biological effect of LPA could be the direct consequence of local production of Autotaxin (ATX) in a given tissue or cell type (1). Recently, we have shown that LPA controls two steps of osteoclastogenesis: the fusion and bone resorption capacity of osteoclasts (2). <h3>Objectives</h3> The aim of this study is to test if ATX produced by osteoclasts could play a direct role in osteoclastogenesis and in bone mass control. <h3>Results</h3> First we observed that Enpp2 (ATX gene) was a target gene of RANK-L and as a consequence was up regulated during the course of osteoclastogenesis from bone marrow (BM) wild type (WT) cells. Next we generated Ctsk- Cre+;ATXfl/fl mice and use of these animals as a source of osteoclasts-ATX deficient progenitors. In vitro experiments showed a major impact of ATX on osteoclastogenesis and osteoclast mediated bone resorption. Because LPA is massively present in sera, to explore either LPA or ATX putative effect in culture, the use of delipidated serum was mandatory. Using such conditions, we observed a drastic reduction in the number of mature osteoclasts after 5 days of differentiation from BM-WT progenitors, but osteoclasts number were restored by the use of LPA, recombinant ATX plus LPC, or LPC. These results were confirmed by the use of LPA and ATX specific inhibitors (KI16425 and PF8380). Osteocorning bone resorption assays showed that ATX is required for osteoclasts activity, that decreased of 50% when delipidated sera is used in the assays and that was fully restored by the addition of either LPC or recombinant ATX plus LPC. <h3>Conclusions</h3> All together, and more specifically the results obtained in presence of LPC alone suggest that (i) ATX is secreted by osteoclasts and (ii) is functionally involved in osteoclast differentiation and function in vitro. Current studies are conducted on Ctsk-Cre+;ATXfl/fl mice to fully characterize the role of ATX in the bone mass control in physiological and pathological conditions due to ageing (osteoporosis) and inflammation (rheumatoid arthritis). <h3>References</h3> Nishimura S. et al Diabetes. 2014 Dec;63(12):4154–64) David M.et al J Biol Chem. 2014 Mar 7;289(10):6551–64 <h3>Disclosure of Interest</h3> None declared
AB1009 An Epidemiological Study of The Prevalence Rate of IBP and Axial SpA in The University in The South of China: Table 1.
Authors: Z. Lin, F. Tong, Z. Hu, L. Fang, X. Chen, Q. Lv, Z. Liao, J. Gu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> In China, there is little research supply the data of the prevalence rate of IBP and axial spondyloarthritis (axial SpA). However, IBP and axial spondyloarthritis were common in China, so it is important to get the data about them. <h3>Objectives</h3> Inflammatory back pain (IBP) is an important clinical features for ankylosing spondylitis and axial spondyloarthritis. We conducted an epidemiological study in a university detect prevalence rate of IBP and axial SpA. <h3>Methods</h3> 3770 students from South China Agricultural University were enrolled in our study. We investigate the patients information by questionnaires face to face. We collected patients9 parameters including the parameters for diagnosis of IBP criteria (ASAS), which include onset age, insidious onset, improvement with exercise, no improvement with rest and pain at night. We also collected the parameters for diagnosis of axial spondyloarthritis criteria (ASAS). To assess prevalence rate of IBP and axial spondyloarthritis. <h3>Results</h3> (1) Data of the 3770 students enrolled were shown as follows: mean age was 19.48±2.80 years; female to male ratio was 1.45:1 (2229/1541). (1) 731 students (19.39%) had back pain. In these students, female to male ratio was 1.97:1 (485/246). (2) In patients who had the back pain, 111 (15.18%) students had IBP. In other word, in all students who involved in, 2.94% of them had Inflammatory back pain IBP. (3) After investigation, we found 333 students had received the HLA-B27 examination. 19 (5.71%) students were positive. And 13 students (3.90%) of them who had result of HLA-B27 were diagnosed as axial SpA. Based on the data, the prevalence rate of back pain and IBP was 19.39% and 2.94%, respectively. The prevalence rate of axial SpA were 3.90%. (4) Although more female students than male ones had back pain, more male than female ones were diagnosed as axial SpA (Back pain: Female/Male: 485/246, Axial SpA:Female/Male:4/9; P=0.014). <h3>Conclusions</h3> In the south of China, the prevalence rate of back pain and IBP was 19.39% and 2.94% in university respectively, and the prevalence rate of axial SpA were 3.90%. Although more female students than male ones had back pain, male ones were more likely to suffer from axial SpA. <h3>Acknowledgement</h3> This study was supported by 5010 Subject (2007) of Sun Yat-Sen University, the National Natural Science Foundation for the Youth NSFY of China (Grant no. 81302583), and the Fundamental Research Funds for the Central Universities (12ykpy34) and the Natural Science Foundation of Guangdong Province (Outstanding youth Project)(2014A030306039), and the project of science and technology new star in Zhu Jiang Guangzhou city. <h3>Disclosure of Interest</h3> None declared
Clonal Diversity of Recurrently Mutated Genes in Myelodysplastic Syndromes
Authors: Devendra K Hiwase, Chris N Hahn, Milena Babic, Sarah Moore, Carolyn M Butcher, Monika M Kutyna, Deepak Singhal, Jinghua Feng, Bik To, Andreas Schreiber, Hamish S Scott
Journal: Blood (2014)
Treatment with Hsp90 Inhibitor, 17-AAG Overcomes Resistance to Small Molecule FLT3-Inhibitors in FLT3/ITD-Positive Leukemia Cells Harboring N676K-Mutation.
Authors: Yosuke Minami, Yuka Nomura, Akihiro Abe, Ryohei Tanizaki, Yachiyo Kuwatsuka, Hitoshi Kiyoi, Tomoki Naoe
Journal: Blood (2008)
P0056 : The impact of metabolic syndrome and prevalent liver disease on living donor liver transplantation: A pressing need to expand the pool
Authors: W. Al-Hamoudi, F. Abaalkhail, A. Bendahmash, N. Allam, N. Almasri, H. Al-bahili, M. Al-Sebayel, D. Broering, H. Elsiesy
Journal: Journal of Hepatology (2015)
Validation of the HEMOCLOT® Direct Thrombin Inhibitor Assay for Dabigatran by Comparison with a Validated LC-MS/MS Method in Plasma Samples From Patients After Major Orthopaedic Surgery
Authors: Joachim Stangier, Bengt I Eriksson, Michael H Huo, Richard J Friedman, Ola E Dahl, Martin Feuring
Journal: Blood (2011)
AB0846 Does diabetes Mellitus Cause Problems in Hand Functions and Quality of Life?
Authors: E. Ceceli, S. Gümrük, S. Kocaoğlu, F. Ayhan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Diabetes mellitus (DM) is a chronic condition which can effect different systems of the body <h3>Objectives</h3> In this study we aimed to determine the impairments in hand and upper extremity functions, pain and quality of life in diabetic patients. <h3>Methods</h3> Fifty diabetic patients who attended to physical medicine and rehabilitation outpatient clinics were evaluated. The patients fasting blood glucose levels, hemoglobin A1 C levels, body mass indexes were detected; existing hand deformities were noted; evaluations of hand strength was made by hand grip strength, hand pain by VAS, hand skills by purdue pegboard test and nerve involvement by semmes weinstein monofilaments (SWM). For upper extremity functions Disabilities of Arm Shoulder and Hand scores (DASH) and for quality of life Nottingham Health profile (NHP) test were selected. <h3>Results</h3> The mean age of the patients were 62,76±10,99 years. Among our DM patients only 4 patients had normal weight, 14 were over weight, 29 were obese and 4 had morbid obesity. The mean valueof fasting blood gucose was 145,2 and that of HbA1 c was 7,64. In hand evaluations we found trigger finger and dupuytren contracture in 10,6%, restricted hand mobility in 3,4%,crepitation of hand tendons in 55,3% and carpal tunnel syndrome in 38,3%. SWM median nerve mean values were 3,64±0,68 and that of ulnar nerve was 3,77±0,83.In correlation analysis we found hand pain by VAS correlated all evaluation parameters except purdue pegboard test. SWM scores correlated with all subgroups of NHP, purdue pegboard test and hand pain by VAS. DASH scores correlated with HbA1 c levels, abdominal circumference, grip strength and SWM evaluations. <h3>Conclusions</h3> In our diabetic patients we found nearly all patients were obese or overweight; had problems both in hand functions and median - ulnar nerves. Involvement of the nerves leads to problems in quality of life and fine skills of hands. Additional upper extremity impairments increase their pain and disability. As a result we suggest the patients to have a strict glucose control for a better life standard. <h3>Disclosure of Interest</h3> None declared
Lower Leukocytosis with Biosimilar Compared with Originator G-CSF during Autologous Stem Cell Mobilization after Chemotherapy in Lymphoma and Multiple Myeloma Patients. a Pharmacovigilance Study of “Rete Ematologica Lombarda” (FARMA-REL)
Authors: Anna Maria Pelizzari, Paola Tozzi, Francesca Bocchio, Maurizio Bonfichi, Silvia Artuso, Nicola Fracchiolla, Valentino Conti, Pierino Ferremi, Camillo Almici, Daria Bettoni, Vincenza Orlando, Giuseppe Rossi, Giuliana Muti
Journal: Blood (2014)
Non-Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation (SCT) with Pre-Transplant Targeted Immune Depletion Results in Rapid Full Donor Engraftment in Pediatric Patients with Malignancy.
Authors: Terry J. Fry, Teresa Cardesa-Salzman, Frances Hakim, Cynthia Love, Paula Layton, Ronald Gress, Daniel Fowler, Michael R. Bishop, Crystal L. Mackall, Alan S. Wayne
Journal: Blood (2005)
Long-Term Survival After Donor Lymphocyte Infusion For Hematological Malignancies After Allogeneic Hematopoietic Cell Transplantation
Authors: Nina Worel, Peter Kalhs, Werner Rabitsch, Margit Mitterbauer, Axel Schulenburg, Gerda Leitner, Hildegard T Greinix
Journal: Blood (2013)
IKZF1 Deletion Is Strongly Associated with Risk of Relapse in Pediatric B Cell Precursor ALL with TCF3-PBX1
Authors: Daisuke Asai, Toshihiko Imamura, So-ichi Suenobu, Akiko Moriya Saito, Daiichiro Hasegawa, Takao Deguchi, Hashii Yoshiko, Mikiya Endo, Naoki Hatakeyama, Hirohide Kawasaki, Hiroki Hori, Keizo Horibe, Keiko Yagi, Junichi Hara, Megumi Oda, Atsushi Sato
Journal: Blood (2012)
New Role of Antiphospholipid Antibodies (APLA)? Correlations with Disease Activity in Non-Thrombotic and Thrombotic Autoimmune and Hematologic Disorders.
Authors: Lawrence L. Horstman, Carlos J. Bidot, Wenche Jy, Vincenzo Fontana, Pamela Duckiewicz, Eugene R. Ahn, Joaquin J. Jimenez, Yeon S. Ahn
Journal: Blood (2005)
Dissociating GVT from GVHD in Murine BMT Models through TNFα Dependent CD4+ T Cell Mediated GVHD and IFNγ Dependent CD8+ T Cell Mediated Anti-Tumor Effects.
Authors: William J. Murphy, Minghui Li, Angela Panoskaltsis-Mortari, Bruce R. Blazar, Thomas J. Sayers, Sergei Nedospasov, Dennis D. Taub, Lisbeth A. Welniak, Kai Sun
Journal: Blood (2007)