tbuckley/cabot-search huggingface dataset:
Paregoric and Tripelennamine ('Blue Velvet') Addiction Increasing, Claims Detroit Pathologist
Authors: A S ZELICKSON, H C ZELLER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Occurence of psychiatric disorder in a county jail population
Authors: G E Swank, D Winer
Journal: American Journal of Psychiatry (1976)

The authors report on a year's experience in providing psychiatric services in a county jail setting. Of 545 inmates evaluated, 22% were diagnosed as psychotic and 23% had a history of long-term or multiple hospitalizations. The authors discuss the implications of these data in terms of the problem of providing adequate psychiatric care for such a population.
Endoscopic therapy of Zenker’s diverticulum using a novel endoscopic scissor – the Clutch Cutter device
Authors: Helmut Neumann, Silke Löffler, Stefanie Rieger, Claudia Kretschmer, Andreas Nägel
Journal: Endoscopy (2015)

Zenker's diverticulum is a diverticulum of the mucosa of the pharynx above the cricopharyngeal muscle, which often causes clinical symptoms including dysphagia, regurgitation, cough, and halitosis [1]. Endoscopic therapy is based on cutting the septum between the diverticulum and the esophageal lumen. A variety of endoscopic methods have been used for this procedure, including laser, stapler, harmonic scalpel, argon plasma coagulation, and needle-knives [1] [2] [3] [4]. Here, we describe the use of a novel device, which was originally developed for endoscopic submucosal dissection (ESD), for the rapid and safe treatment of Zenker's diverticulum.
Inequalities in Health
Authors: John Lister
Journal: New England Journal of Medicine (1980)

IN 1977, Mr. David Ennals, then Secretary of State in the Department of Health and Social Security (D.H.S.S.), set up a working group to study the problems of inequalities in health. The chairman was Sir Douglas Black, president of the Royal College of Physicians of London, who was chief scientist at the D.H.S.S. at the time. The other members of the group were Prof. Norman Morris, professor of community health at the London School of Hygiene and Tropical Medicine, Dr. Cyril Smith, secretary of the Social Science Research Council, and Prof. Peter Townsend, professor of sociology at the University of . . .
Paying Attention
Authors: N S Prose
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of Different Factors on the Formation of Calcium Oxalate Stones II. Discriminant Analytical Computations of Morphological Parameters of Pelvic-Calyceal Systems and Clinicochemical Urine Parameters of Controls and Calcium Oxalate Stone Formers
Authors: E Schulz, R Börner, P Brundig, F Mäurer
Journal: European Urology (1989)
Reductions in coverage for mental and nervous illness in the Federal Employees Health Benefits Program, 1980-1984
Authors: E Hustead, S Sharfstein, S Muszynski, J Brady, J Cahill
Journal: American Journal of Psychiatry (1985)

After nearly 15 years of nondiscriminatory coverage, the largest plan in the Federal Employees Health Benefits Program cut its coverage of care for mental illness disproportionately to coverage for other health care in 1981 and 1982. "Catastrophic" coverage for inpatient mental illness care was introduced by many of the plans in 1984. The authors review the reductions in coverage from economic and clinical perspectives, highlighting the impact of the disparity between the coverage for mental illness and other medical conditions. The model of catastrophic protection for treatment of mental illness set forth in the Federal Employees Health Benefits Program does not bode well for the patient and family who must cope with such a financial contingency.
Onychomadesis outbreak in Valencia, Spain, June 2008
Authors: A Salazar, I Febrer, S Guiral, M Gobernado, C Pujol, J Roig
Journal: Eurosurveillance (2008)

Onychomadesis describes complete nail shedding from the proximal portion. It is consecutive to a nail matrix arrest and can affect both fingernails and toenails. It is a rare disorder in children. Except for serious generalised diseases or inherited forms, most cases are considered to be idiopathic. Nail matrix arrest has been associated with a variety of drug exposures and systemic illnesses, including infections, and may result in a variety of changes, including transverse ridging (Beau's lines) and nail shedding (onychomadesis).
Management of pulmonary embolism.
Authors: G de TAKATS
Journal: BMJ (1968)

PointersRh immunization: About 8.5 0, of 760 mothers developed Rhesus antibodies six months after first pregnancy, and a further 8.500 by the end of the second pregnancy.Evidence is presented of relation between post-delivery foetal cell count and risk of developing antibodies (p.139) ; Leader at p. 135.Calcium and Dialysis: Metastatic calcification considered less likely after calcium concentration is raised to optimum level (p.145) ; Group of patients with terminal renal failure developed parathyroid autonomy, but function tended to revert to normal with continued dialysis (p.150).Common Cold: Influenza C virus caused respiratory tract disease in 26 volunteers, and 9 had common cold symptoms (p.153).Perforated D.U.: Vagotomy and pyloroplasty performed as emergency gave equally satisfactory results as elective surgery when compared over a six-year period (p.155).Sight Testing: Use of blocks instead of letters with young children proved a satisfactory method (p.157).Pregnancy and Vitamin B12: Caution recom- mended in administering folate unless serum B12 levels measured, especially in older women (p.158) ; Survey showed B12 levels higher in West Indian population than in Europeans even during pregnancy (p.160).
Urinary Sediment.
Authors: G. E. Schreiner
Journal: Annals of Internal Medicine (1963)

s1 April 1963Urinary Sediment.G. E. Schreiner, M.D., F.A.C.P.G. E. Schreiner, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-744_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCareful examination of urinary sediment is the single most important laboratory examination that can be done in a physician's office or in a hospital. For maximum value, the microscopic examination should be done by the physician himself after he has taken the patient's history and performed the physical examination.Newer techniques of microscopy, including polarized light and phase contrast, and new histochemical techniques such as the use of supravital stains, have enhanced the value of the urinary sediment.Color slides illustrate the important findings that may be seen with urinary microscopy with the use of all of these techniques.Interpretation... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: G. E. Schreiner, M.D., F.A.C.P.Affiliations: Washington, D. C. (ML) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 744-744KeywordsLight microscopyMicroscopyResearch laboratories ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
Computed tomographic brain scanning in four neuropsychiatric disorders of childhood
Authors: D F Harcherik, D J Cohen, S Ort, R Paul, B A Shaywitz, F R Volkmar, S L Rothman, J F Leckman
Journal: American Journal of Psychiatry (1985)

CAT scans were performed in 66 patients with neuropsychiatric disorders of childhood (infantile autism, attention deficit disorder, Tourette's disorder, and language disorder) and a control group of 20 medical patients. Ventricular volume and brain density were determined by quantitative, computer-based methods by researchers blind to the patients' diagnoses. There were no significant differences among diagnostic groups or between neuropsychiatric patients and medical control patients in total ventricular volume, right-left ventricular volume ratio, ventricular asymmetries, ventricle-brain ratios, or brain density.
Glucose Control and Cardiovascular Disease in Type-2 Diabetes: A Meta-Analysis
Authors: Tanika N. Kelly, Lydia A. Bazzano, Vivian A. Fonseca, Tina K. Thethi, Kristi Reynolds, Jiang He
Journal: Annals of Internal Medicine (2010)

Background
Results from clinical trials examining the effect of intensive glucose control on cardiovascular disease have been conflicting.
Initial combination therapy with ambrisentan and tadalafil in connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH): subgroup analysis from the AMBITION trial
Authors: John Gerry Coghlan, Nazzareno Galiè, Joan Albert Barberà, Adaani E Frost, Hossein-Ardeschir Ghofrani, Marius M Hoeper, Masataka Kuwana, Vallerie V McLaughlin, Andrew J Peacock, Gérald Simonneau, Jean-Luc Vachiéry, Christiana Blair, Hunter Gillies, Karen L Miller, Julia H N Harris, Jonathan Langley, Lewis J Rubin
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Patients with connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH), in particular systemic sclerosis (SSc), had an attenuated response compared with idiopathic PAH in most trials. Thus, there is uncertainty regarding the benefit of PAH-targeted therapy in some forms of CTD-PAH. <h3>Objective</h3> To explore the safety and efficacy of initial combination therapy with ambrisentan and tadalafil versus ambrisentan or tadalafil monotherapy in patients with CTD-PAH and SSc-PAH enrolled in the AMBITION trial. <h3>Methods</h3> This was a post hoc analysis of patients with CTD-PAH and SSc-PAH from AMBITION, an event-driven, double-blind trial in patients with WHO functional class II/III PAH. Treatment-naive patients were randomised 2:1:1 to once-daily initial combination therapy with ambrisentan plus tadalafil or monotherapy with ambrisentan or tadalafil, respectively. The primary endpoint was time to the first clinical failure event (first occurrence of death, hospitalisation for worsening PAH, disease progression or unsatisfactory long-term clinical response). <h3>Results</h3> In the primary analysis set (N=500), 187 patients had CTD-PAH, of whom 118 had SSc-PAH. Initial combination therapy reduced the risk of clinical failure versus pooled monotherapy in each subgroup: CTD-PAH (HR 0.43 (95% CI 0.24 to 0.77)) and SSc-PAH (0.44 (0.22 to 0.89)). The most common AE was peripheral oedema, which was reported more frequently with initial combination therapy than monotherapy in the two PAH subgroups. The relative frequency of adverse events between those on combination therapy versus monotherapy was similar across subgroups. <h3>Conclusions</h3> This post hoc subgroup analysis provides evidence that CTD-PAH and SSc-PAH patients benefit from initial ambrisentan and tadalafil combination therapy. <h3>Trial registration number</h3> NCT01178073, post results.
Drug Allergy
Authors: Charles W. Parker
Journal: New England Journal of Medicine (1975)

UNTOWARD reactions to drugs are an important medical problem. It was recently estimated that as many as 5 per cent of medical hospital admissions are due to drug reactions and that a minimum of 15 per cent of hospitalized patients experience at least one adverse drug reaction.1 The term allergic is applied to reactions that are immunologically mediated as opposed to reactions due to pharmacologic idiosyncrasy, direct toxicity, overdosage, side effects or interactions between drugs. Although allergy is not the most common cause of untoward drug symptoms it is often involved in the more serious reactions. . . .
Reparable Cell Sonoporation in Suspension: Theranostic Potential of Microbubble
Authors: S Moosavi Nejad, Hamid Hosseini, Hidenori Akiyama, Katsuro Tachibana
Journal: Theranostics (2016)

The conjunction of low intensity ultrasound and encapsulated microbubbles can alter the permeability of cell membrane, offering a promising theranostic technique for non-invasive gene/drug delivery. Despite its great potential, the biophysical mechanisms of the delivery at the cellular level remains poorly understood. Here, the first direct high-speed micro-photographic images of human lymphoma cell and microbubble interaction dynamics are provided in a completely free suspension environment without any boundary parameter defect. Our real-time images and theoretical analyses prove that the negative divergence side of the microbubble's dipole microstreaming locally pulls the cell membrane, causing transient local protrusion of 2.5 µm in the cell membrane. The linear oscillation of microbubble caused microstreaming well below the inertial cavitation threshold, and imposed 35.3 Pa shear stress on the membrane, promoting an area strain of 0.12%, less than the membrane critical areal strain to cause cell rupture. Positive transfected cells with pEGFP-N1 confirm that the interaction causes membrane poration without cell disruption. The results show that the overstretched cell membrane causes reparable submicron pore formation, providing primary evidence of low amplitude (0.12 MPa at 0.834 MHz) ultrasound sonoporation mechanism.
PWE-405 Emergency general surgery; are trainers and trainees perspectives in line with population needs?
Authors: L Pearce, C Hall
Journal: Gut (2015)

<h3>Introduction</h3> More consultant surgeon posts (around 20%) are being advertised for general and emergency surgeons, but is this in line with the expectations of trainees and consultants? <h3>Method</h3> An online tool was used to design, collect and analyse 2 online surveys (www.surveymonkey.net) to determine UK experience and attitudes towards Emergency General Surgery (EGS). One online link was distributed to Consultant members of the ASGBI excluding those appointed as EGS Consultant and a different link to all UK trainees in numbered training posts. <h3>Results</h3> 229 (28%) Consultants and 309 (22%) trainees responded. Whilst 16% of consultants surveyed already work in institutions with Emergency Surgeons, most trainees are seeking appointments in city teaching hospitals and have no interest in EGS beyond normal rota provision with only 8.2% declaring a long term career interest in EGS. Nearly half of consultants expect EGS to become a subspecialty but a similar proportion of trainees said they would not consider an EGS consultant post under any circumstances. Reasons included perception of a sub-consultant specialty, poor work life balance, lack of operating, risk of de-skilling and earning potential. More recently appointed consultants (50%) felt a dedicated period of EGS training would have better prepared them for EGS when compared with those in post for ten years or more (17%, p = 0.022). EGS aspects cited as ‘unexpected’ by consultants in post included poorly trained registrars and management of trauma patients. Most trainees (72%) favour a 6 month dedicated training period in EGS. <h3>Conclusion</h3> Increasing advertisements for EGS posts reflects public and societal need for EGS service provision but training programmes and trainee aspirations may not be meeting this need. A dedicated period of EGS for trainees may address this problem. Trainees with an interest in EGS should be encouraged to pursue a career in this developing specialty. <h3>Disclosure of interest</h3> None Declared.
Comparison of Spatial Instantaneous ECG Vectors, Measured with the SVEC, with Mean Vectors Derived from Conventional ECG Leads
Authors: ERNST SIMONSON, OTTO H. SCHMITT, RAPHAEL B. LEVINE
Journal: Circulation Research (1955)

Two approaches to the analysis of spatial electrocardiographic vectors are currently being used: construction from the conventional ECG leads, and measurements from oscilloscopic recordings of spatial loops. There are several fundamental differences between the approaches, and there is no a priori certainty that equivalent or even similar phenomena are being investigated. This study presents a statistical comparison between mean spatial vectors, constructed from the conventional ECG, and instantaneous maximum spatial vectors, determined with the stereovector electro-cardiographic technic.
The transition to practice seminar
Authors: J F Borus
Journal: American Journal of Psychiatry (1978)

The author discusses the lack of organized faculty attempts to facilitate psychiatric residents' transition to professional practice. Interviewed residents suggested that faculty discontinue their "benign neglect" of the transition and provide information and discussion regarding the realities of different types of practice. He describes the six-session seminar he developed at Massachusetts General Hospital, which focuses on the process of transition from residency to practice, emphasizes the role of faculty as decision facilitators, and explores the costs and benefits of different types of psychiatric practice.
Autologous hematopoietic stem cell transplantation with a rituximab-containing preparative regimen for non-Hodgkin lymphoma
Authors: R. T. Kamble, R. May, S. Ganguly, H. E. Heslop, M. K. Brenner, G. Carrum
Journal: Journal of Clinical Oncology (2007)

7112 Background: We investigated the safety and outcome after adding Rituximab to our standard high-dose chemotherapy conditioning regimen with BEAM in patients receiving autologous hematopoietic stem cell transplantation. Methods: Between November 2002 and May 2006, 25 consecutive patients with relapsed high-risk NHL (diffuse large B cell = 15, transformed follicular =10) were enrolled. The high-dose chemotherapy regimen consisted of BEAM with rituximab administered at 375 mg/m 2 IV on days −6, +14, +21 and +28. Rituximab associated delayed neutropenia was defined as ANC of &lt; 500 occurring at least 4 weeks after the last dose of rituximab. B cell and T cell reconstitution data was measured using phenotypic analysis for CD3, CD4, CD8, CD56, CD19 and CD20. Results: The median age was 55 years (range 22–69 years). The disease status at transplant included advanced disease (≥CR-2) in 15 while 10 had primary refractory disease. The previous initial and or salvage chemotherapy included Rituximab in all 25 patients. A median of 4.47 ×10 6 /kg CD 34 + cells were infused resulting in neutrophil and platelet engraftment at 11 (10–23) and 21 (14–56) days respectively. The median time to T cell reconstitution (CD3 &gt;1,000/uL) was 32 days, B cell recovery was delayed beyond 1 year with median of 72 CD19+ve cells/uL at 1 year. 24 (96%) patients achieved complete remission after transplant and 1 had a partial response. There was no transplant related mortality. Nine patients relapsed at a median of 4 months (2–23 months). 6 patients died at a median of 15 months from transplant (relapsed lymphoma =4 and secondary MDS=2). At a median follow-up of 24 months, the disease free survival and overall survival is 52% and 75% respectively. Rituximab associated delayed neutropenia occurred in 3 (12%) patients at a median of 39 (31–64) days from the last dose of rituximab and resolved at a median of 14 days (7–38) with or without filgrastim support. There were no infectious complications associated with neutropenia or delayed B cell recovery. Conclusion: Incorporation of rituximab into a high dose chemotherapy conditioning regimen is safe. Delayed B cell reconstitution and Rituximab associated delayed neutropenia are common but not associated with significant infectious complications. No significant financial relationships to disclose.
BMA Annual Representative Meeting: Doctors call for a smoking ban in public places
Authors: Linda Beecham
Journal: BMJ (2003)

BMA has voted overwhelmingly for a ban on smoking in public places. Speakers at the annual representative meeting said that a ban was needed to protect people from secondhand smoke in restaurants, bars, taxis, and all workplaces. Dr Colin Hamilton, a public health doctor in Northern Ireland, pointed to the medical evidence to support a ban. There is a 20% to 30% increase in lung cancer and a 20% to 35% increase in heart disease for people exposed on a long term basis to secondhand smoke, he said. He praised the recent decision of the government in the Republic of Ireland to introduce a ban and called on the governments in all parts of the United Kingdom to do the same. Dr Hamilton said that he opposed draconian measures against people who broke the law. The legislation should come in and then take some time to be accepted.  chairman of the National Heart Forum, Alexander Macara, wanted to know why nothing had been done when it was what most non-smokers and even many smokers wanted. It was because the government was scared stiff of being accused of running a nanny state, he suggested.
Deep-Seated Mycotic Infections, Allergy to Fungi and Mycotoxins
Authors: Donald B. Louria
Journal: New England Journal of Medicine (1967)

HistoplasmosisDuring the last five years, there has been increasing awareness of previously overlooked aspects of histoplasma infection in man. Schwarz, Baum and Floyd have emphasized that multiple primary lesions may occur in the lungs simultaneously, producing roentgenologic infiltrates which wax and wane for a period of months or years before eventual healing.104 Mediastinal adenopathy due to Histoplasma capsulatum has produced obstruction of both the trachea and the superior vena cava.105 , 106 I have observed a case of Loeffler's syndrome due to histoplasma infection and have also seen a patient who had wandering pneumonia involving, over a two-year period, all 5 . . .