tbuckley/cabot-search huggingface dataset:
At a Loss
Authors: Anand Vaidya, Paiman P. Ghoroghchian, Joseph F. Merola, Martin A. Samuels
Journal: New England Journal of Medicine (2012)

A 31-year-old woman presented to the emergency department with an 8-month history of nausea and episodic epigastric pain that was accompanied by fatigue, headache, loss of appetite, and loose stools. During a review of systems, she also noted numbness and tingling in both hands and both feet, as well as difficulty walking for the past 3 months. She reported no fever, muscle weakness . . .
Risk factors and correlates of severe psychiatric disorders in a sample of inpatient children
Authors: J H Kashani, A C Dandoy, A F Vaidya, S M Soltys, J C Reid
Journal: American Journal of Psychiatry (1990)

This study used three informants to assess pervasiveness of psychopathology in a sample of 100 psychiatrically hospitalized children. Analyses of risk factors for severely disturbed and less disturbed children revealed that hopelessness, anxiety, low self-esteem, undisciplined personality profile, and negative life events differentiated the severely disturbed group from the less disturbed group. Implications of these findings are discussed, with an emphasis on the importance of focusing on degree of psychopathology with regard to risk factors.
Resolving complex structural genomic rearrangements using a randomized approach
Authors: Xuefang Zhao, Sarah B. Emery, Bridget Myers, Jeffrey M. Kidd, Ryan E. Mills
Journal: Genome biology (2016)

Complex chromosomal rearrangements are structural genomic alterations involving multiple instances of deletions, duplications, inversions, or translocations that co-occur either on the same chromosome or represent different overlapping events on homologous chromosomes. We present SVelter, an algorithm that identifies regions of the genome suspected to harbor a complex event and then resolves the structure by iteratively rearranging the local genome structure, in a randomized fashion, with each structure scored against characteristics of the observed sequencing data. SVelter is able to accurately reconstruct complex chromosomal rearrangements when compared to well-characterized genomes that have been deeply sequenced with both short and long reads.
64P Survival outcome of weak estrogen /progesterone receptor expression in Her2 negative breast cancer is similar to triple negative breast cancer
Authors: G.-S. Liao, H.-M. Hsu, C.-H. Chu, Z.-J. Hong, C.-Y. Fu, Y.-C. Chou, T.-C. Huang, M.-S. Dai, J.-C. Yu
Journal: Annals of Oncology (2015)
Abstract P312: Lack of Association Between Habitual Sleep Duration and Obesity Measures in Adolescents with Adequate Sleep
Authors: Fan He, Edward O Bixler, Julio Fernandez-Mendoza, Alexandros N Vgontzas, Arthur Berg, Yuka Imamura Kawasawa, Duanping Liao
Journal: Circulation (2016)

Introduction: In general, 7-8 hours/night of sleep is considered as adequate amount of sleep. Although subjectively reported sleep duration has been associated with obesity, the relationship between objectively-measured sleep duration and obesity has been reported inconsistently. Hypothesis: We assessed the hypothesis that there is lack of association between objectively-measured sleep duration and obesity measures in adolescents who generally sleep adequately. Methods: We used data from 421 adolescents in the Penn State Child Cohort follow-up examination. Polysomnography (PSG) was used to objectively measure the sleep duration for one night. Actigraphy was used for 7 consecutive nights to objectively measure and calculate each participant’s habitual mean sleep duration. Anthropometric measurements, including waist circumference, weight, and height, were collected from each participant. Age and sex-specific BMI percentile was calculated. The participants also underwent a dual-energy x-ray absorptiometry scan to assess abdominal obesity, as measured by Android/Gynoid (A/G) fat ratio, Android/whole body (A/W) fat proportion, visceral fat area, and subcutaneous fat area. Multivariable adjusted linear regression was used to analyze the association between sleep duration and obesity measures. Results: The means (SD) of the PSG and actigraphy-measured sleep duration were 7.4 (0.9) and 7.0 (0.8) hours, respectively. As shown in the table, objectively-measured sleep duration was not significantly associated with BMI percentile, after controlling for age, race, sex, and AHI. After further adjustment for BMI percentile, none of the regression coefficients between sleep duration and abdominal obesity measures reached statistical significance. Conclusions: In adolescents with generally adequate amount of sleep, there is lack of association between habitual sleep duration and obesity measures. The findings should not be generalized to adolescents whose sleep duration is outside the range of our data.
Hormonal Therapy for Breast Cancer
Authors: J Espinós, C Reyna, S de la Cruz, C Oiler, A Hernández, O Fernández Hidalgo, M Santisteban, J García Foncillas
Journal: CA A Cancer Journal for Clinicians (2005)

Hormonal therapy has been the first systemic treatment against breast cancer. Up to now Tamoxifen and ovarian supression/ablation were the best optionts we had to treat early breast cancer as advancer disease. The advent of aromatase inhibitors, new SERMS and antistrogen Fulvestrant have supoused a great advance in the treatment of this disease and at the same time have complicated the election of the optimal drug for each patient. This article tries to review the aviable treatment options insiting on its indications.
Consumer
Authors: H.J. Van Peenen
Journal: Annals of Internal Medicine (1999)

On Being a Patient21 December 1999ConsumerH.J. Van Peenen, MDH.J. Van Peenen, MDPonca City, OK 74604 (Van Peenen)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-131-12-199912210-00014 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail When Dr. Burton Moerdop retired, he moved to his mother's home town, Pota City, Oklahoma. She was 84 years old and for a number of years, she had been reminding him that since he was an only child, she depended on him for her terminal care. The reminding became more urgent after she was admitted to the tiny local hospital with a bowel obstruction.“It's time you came home,” she said when he flew out to keep her company at the hospital. She was quite insistent.Dr. Moerdop suggested that it would be better if she would move to him ... Author, Article, and Disclosure InformationAffiliations: Ponca City, OK 74604 (Van Peenen)Corresponding Author: H.J. Van Peenen, MD, 1414 East Hartford, Unit 9, Ponca City, OK 74604. For reprint orders in quantities exceeding 100, please contact the Reprints Coordinator; phone, 215-351-2657; e-mail, [email protected]acponline.org. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLife on the Receiving End: A Qualitative Analysis of Health Providers??? Illness Narratives 21 December 1999Volume 131, Issue 12Page: 976-978KeywordsCholesterolHIVHemoglobinInsulinMedicarePatient advocacyResearch laboratoriesStatinsTemperatureType 2 diabetes ePublished: 15 August 2000 Issue Published: 21 December 1999 Copyright & PermissionsCopyright © 1999 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Growth and Survival of Sarcoma 37 in Various Mouse Stocks
Authors: J. Leiter, I. Kline
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Growth and Survival of Sarcoma 37 in Various Mouse Stocks Get access J. Leiter, J. Leiter Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Kline I. Kline Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 2, October 1953, Pages 449–454, https://doi.org/10.1093/jnci/14.2.449 Published: 01 October 1953 Article history Received: 24 June 1953 Published: 01 October 1953
PTU-233 Transanal haemorrhoidal dearterialization (THD) and targeted mucopexy for haemorrhoids: 215 consecutive patients in a district general hospital
Authors: HM Joshi, N Ormsby, S Singh, M Chadwick, M Scott, A Samad, R Rajaganeshan
Journal: Gut (2015)

<h3>Introduction</h3> This study aims to evaluate the efficacy of transanal haemorrhoidal dearterialization and Mucopexy (THD+Mpx) in the treatment of symptomatic haemorrhoids and to identify the factors predicting failure for an effective mid-term outcome. <h3>Method</h3> Two hundred and fifteen patients affected by Grade II (27, 13%), III (145, 69%) and IV (39, 18%) symptomatic haemorrhoidal disease underwent THD, with a rectal mucopexy in patients with haemorrhoidal prolapse. The disease was assessed through a specifically designed symptom questionnaire and telephone follow up. A uni- and multivariate analyses of the potential predictive factors for failure were performed. <h3>Results</h3> The overall success rate was 91.5% (197 patients) after a mean follow-up period of 10.7 ± 8.7 months, with a recurrence of haemorrhoidal prolapse, bleeding, and both symptoms in 10 (4.7%), 3 (1.4%) and 5 (2.4%) patients, respectively. The morbidity rate was 16.5%, represented mainly by pain or tenesmus (19 patients, 9.0%). Acute bleeding requiring surgical haemostasis occurred in two patients (0.9%). No serious or life-threatening complications occurred. At univariate analysis age less than 45 and absence of any morbidity at 30 days were all variables significantly protecting from failure, the grade of haemorrhoid and recurrent disease were not significantly associated with failure. <h3>Conclusion</h3> THD Doppler is a safe and effective therapy for haemorrhoidal disease. A tailored mucopexy is important to contain and reduce the symptoms. <h3>Disclosure of interest</h3> None Declared.
Pathogenesis of diabetes mellitus.
Authors: I LEUSEN
Journal: BMJ (1971)

nancy have already begun to be appreciated.These studies add another dimension, carcinogenesis.The administration of stilboestrol to the mother in early pregnancy must now be considered as a probable cause of adenocarcinoma de- veloping in their daughters.The onus on investigators is to refute this contention rather than confirm it, and the story should encourage even greater caution before ad- ministering any drug to a pregnant woman.J. Folkman5 has raised another issue-namely, the possible effects of stilboestrol residue in meat.Apparently since 1954 75% of cattle in America have been fed on stilboestrol to increase their weight.Sweden and other countries have already banned the feeding of this hormone to cattle.8In Britain it has been used on a small scale for some time to fatten veal and some poultry and had been passed as safe under the Voluntary Veterinary Products Safety Protection Scheme.This body was last week super- seded by a Veterinary Products Committee set up under the Medicines Commission, and it is to be hoped the new body will examine the facts afresh.Stilboestrol is used for fattening animals in the veal and poultry trade, being injected in a slow-release preparation under the ear of calves and into the back of the head of chickens.These sites have been chosen because they would not enter into human food.But the extent to which stilboestrol may enter it, and the possible consequences, ought to be looked at again.
PTH-308 High quality local excision for early rectal cancer achieving low recurrence rates: preservation of the rectum is possible
Authors: N Maguire, DK Garg, TS Gill
Journal: Gut (2015)

<h3>Introduction</h3> The role of local excision for early rectal cancer continues to be a topic of debate due to high local recurrence rates. The quality of local excision is an important factor determining risk of local recurrence. Small T1 (Sm1 and Sm2) tumours can be adequately treated with trans-anal excision using specialised techniques such as trans-anal endoscopic microsurgery (TEM) or trans-anal endoscopic operation (TEO). Current practice dictates radical surgery (RS) for all other rectal tumours to achieve acceptable oncological outcomes. <h3>Method</h3> A retrospective analysis of prospectively kept data from a single centre case series of patients treated with TEM for early rectal cancer. We analysed data for patients who had rectal preservation without subsequent RS, and were followed up with regular clinical examination, blood tests, CT chest/abdomen/pelvis and MRI rectum. All local excisions were approved by the local MDT and performed by 2 trained consultant colorectal surgeons. <h3>Results</h3> Sixty eight patients underwent TEM for early rectal cancer between June 2009 and August 2013, 25 patients went on to have RS and 1 TEM was converted intra-operatively to RS. Forty two patients (61.8%), 31 males (73.8%), were followed up with rectal preservation. The mean age was 74 years (S. D =/- 9.8) and ASA grades of patients: ASA I 2.4%; ASA II 35.7%; ASA III 54.8%; and ASA IV 7.1%. The median height of tumour was 7cm (range 1–15), operative time was 90 min (range 30 – 320), and in all cases blood loss was minimal. Median length of stay was 2 days (range 1–17). Median tumour size was 20mm (range 2–50) and the pathological stage was T1 in 20/42 (45.2%) (Sm1 5/20[25%], Sm2 8/20[40%], Sm3 7/20[35%]), T2 in 17/42 (40.5%) and T3 in 3/42 (7.1%) patients. Two patients (4.8%) had no residual tumour following neo-adjuvant therapy/polypectomy. The TEM specimen contained lymph nodes in 6/42 cases (14.3%), positive in 2/42 (4.8%). The overall local recurrence rate was 9.5% (4/42 unfit or unwilling for RS, 2 with involved margins). The local recurrence rate with clear margins was 5.3%. Recurrence rate for T0, T1, T2 and T3 disease was 0% (0/2), 0% (0/19), 6.2% (1/16) and 33.3% (1/3) respectively when excluding recurrences with positive margins. The median length of follow up 17 months (range 3–60) and rectal cancer specific mortality was 2.4% (1 patient unfit for radical surgery with T3 disease). <h3>Conclusion</h3> This case series demonstrates a very low recurrence rate in contrast to most of the published series. We believe the technique and quality of surgery is an important factor contributing to local recurrence following local resection. We propose that further studies should be considered for identifying additional patients in whom rectal preservation can be safely offered. <h3>Disclosure of interest</h3> None Declared.
Natural history of male psychological health, X: Work as a predictor of positive mental health
Authors: G E Vaillant, C O Vaillant
Journal: American Journal of Psychiatry (1981)

A sample of 456 inner city men was prospectively followed from age 14 until age 47. Rates blind to adult outcome assessed the men's childhood success at tasks reflecting Erikson's fourth developmental stage, industry versus inferiority. Childhood assessments were made on the parenting the men received and other psychosocial variables, including social class and IQ, and were compared with independent judgments of these men's mental health and career success at age 47. Capacity to work in childhood predicted the success of these underprivileged men at work in adult life and surpassed social class, multiproblem-family membership, and all other childhood variables in predicting adult mental health and capacity for interpersonal relationships.
Alternation of circadian clock modulates forkhead box protein-3 gene transcription in CD4+ T cells in the intestine
Authors: Gui Yang, Hong Zhang, Yi Liu, Ying Feng, Xiang-Qian Luo, Zhi-Qiang Liu, Xiao-Rui Geng, Shuai Wang, Peng-Yuan Zheng, Bai-Sui Feng, Zhi-Gang Liu, Ping-Chang Yang, Hua-Bin Li, Shan-Dong Wu
Journal: Journal of Allergy and Clinical Immunology (2016)
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1976)

A 29-year-old gravida 4, para 2, received care during her final pregnancy at three different hospitals and died three weeks post partum.Born and having had her first delivery overseas, the patient had a criminal abortion of her second pregnancy at 12 weeks, requiring transfusions and a month of hospital care in the United States for sepsis and pulmonary embolism. In the third, after an uneventful prenatal course, she was admitted to a different hospital in labor with sepsis. Treated vigorously for chorioamnionitis, mother and baby both did well. Numerous blood tests disclosed no blood dyscrasia at either institution. Post . . .
ATCT-25LONG-TERM REMISSION OVER 5 YEARS FOR PATIENT WITH RECURRENT GLIOBLASTOMA TREATED WITH CEDIRANIB/LOMUSTINE
Authors: Jethro Hu, Jaime Richardson, Joanna Wilson, Surasak Phuphanich
Journal: Neuro-Oncology (2015)

BACKGROUND: Cediranib is an orally available pan-VEGFR tyrosine kinase inhibitor. Previously phase III study in patients with recurrent glioblastoma did not meet primary end of progressive-free survival (PFS) (J Clin Oncol. 2013 Sep 10; 31(26): 3212-3218) METHODS: We identified 1 patient, 53-year old Caucasian female, who developed tumor progression of left posterior frontal 1.2 x 1.5 cm in February, 2009 following surgery on 10/15/08 and concurrent temozolomide (TMZ) and radiation therapy from 11/8/08 -1/6/09 with one cycle of maintenance TMZ. She was enrolled in a randomized, phase III, placebo-controlled, partially blinded clinical trial of cediranib either as monotherapy or in combination with lomustine (CCNU) versus CCNU. RESULTS: She was randomized to receive a combination therapy with 1st cycle CCNU 190 mg and cederanib 20 mg/day on 4/13/09. Four weeks later, she developed grade 4 thrombocytopenia (17, 000) associated with gum bleeding and dizziness. She received a platelet transfusion. She continued with cediranib alone and 2nd reduced CCNU 100 mg was delayed till 6/16/09, 3rd CCNU on 2/2/2010. She developed hypertension, proteinuria and diarrhea from cediranib in April of 2010 and she continued with reduced dose to 15 mg/day alone without CCNU. However, she developed nephrotic syndrome and poorly controlled hypertension and was taken off this study in May 2010. At 6-week MRI showed 50% tumor regression (PR) and complete response at 24-weeks. With no enhancement seen on MRI on 6/4/15, she has been off therapy and in clinical remission over 5 years with high functional level and good quality of life (KPS 90%). CONCLUSION: This is a case report of successful therapy for recurrent glioblastoma with long term remission despite termination of therapy > 5 years from cediranib and limited CCNU dosage.
OP0242-PARE Capabilities of European Lupus Groups: Members of Lupus Europe
Authors: K. Lerstrom, B. Rubio
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Lupus patient organizations have a significant role to play in healthcare. They are becoming increasingly important stakeholders in political and medical healthcare decision-making processes. Effective national patient organizations provide advice, education, and support to people living with lupus, their families and healthcare providers. LUPUS EUROPE is an umbrella organization of national lupus groups in Europe. At the onset of a new strategic period it was necessary to assess member groups9 capabilities before initiating development initiatives. <h3>Objectives</h3> To identify the different structures and capabilities among European lupus groups. <h3>Methods</h3> An online survey was distributed to validated contacts within the 22 member countries of LUPUS EUROPE (24 groups). The survey was divided into four sections (i) group aims, structure and funding (ii) resources and network (iii) the situation for people living with lupus in the country (iv) the lupus group needs and wishes in capability building nationally and on European level. Questions offered single answer, multiple response or commentary. <h3>Results</h3> 14 groups (58%) responded from Belgium (2), Cyprus, Denmark, Finland, Greece, Italy, Iceland, Netherlands, Norway, Spain, UK, Sweden and Switzerland. <i>Key results included:</i> 13/14 groups have an elected board of volunteers, 11/14 are run by volunteers Six groups reported having national offices/secretariat function and six groups do not have an office 10 of the responding groups only represented people living with lupus 9 of the 14 groups are affiliated with the arthritis and/or rheumatism associations in the country 12/14 groups cited membership subscriptions as the main source of funding 5/14 groups have an established medical advisory board mainly involved with educational activities on lupus Lack of lupus awareness amongst doctors and time to diagnosis were cited as major challenges for people with lupus in the country 7 of the groups reported SLEDAI used nationally as a measurement index for clinical disease activity assessment 8/12 groups identified need for capacity building in political lobby activities. More than 2/3rds of the groups expect LUPUS EUROPE to support member groups in their advocacy work and provide scene and opportunity to have more people educated and engaged in improving lupus patient interests in research and political work. <h3>Conclusions</h3> There is a diverse range of capabilities and needs amongst national European lupus groups; some are very well established with significant capabilities, while others need capacity building in priority areas. <h3>Acknowledgements</h3> Thank you to member groups, big and small, for all their help and support in the survey, taking the considerable time to fill in the responses and showing interest in the perspectives these findings can give. <h3>Disclosure of Interest</h3> None declared