tbuckley/cabot-search huggingface dataset:
A Woman in Emotional Distress With Chest Pain
Authors: Daniel O. Johnsrud, Colleen E. Lane, Hector I. Michelena
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
[18F]FDG PET signal is driven by astroglial glutamate transport
Authors: Eduardo R Zimmer, Maxime J Parent, Débora G Souza, Antoine Leuzy, Clotilde Lecrux, Hyoung-Ihl Kim, Serge Gauthier, Luc Pellerin, Edith Hamel, Pedro Rosa-Neto
Journal: Nature Neuroscience (2017)
Colloidal Gold Nanoclusters Spiked Silica Fillers in Mixed Matrix Coatings: Simultaneous Detection and Inhibition of Healthcare‐Associated Infections
Authors: Shahad K. Alsaiari, Mohammed A. Hammami, Jonas G. Croissant, Haneen W. Omar, Pradeep Neelakanda, Tahir Yapici, Klaus‐Viktor Peinemann, Niveen M. Khashab
Journal: Advanced Healthcare Materials (2017)

Healthcare‐associated infections (HAIs) are the infections that patients get while receiving medical treatment in a medical facility with bacterial HAIs being the most common. Silver and gold nanoparticles (NPs) have been successfully employed as antibacterial motifs; however, NPs leaching in addition to poor dispersion and overall reproducibility are major hurdles to further product development. In this study, the authors design and fabricate a smart antibacterial mixed‐matrix membrane coating comprising colloidal lysozyme‐templated gold nanoclusters as nanofillers in poly(ethylene oxide)/poly(butylene terephthalate) amphiphilic polymer matrix. Mesoporous silica nanoparticles–lysozyme functionalized gold nanoclusters disperse homogenously within the polymer matrix with no phase separation and zero NPs leaching. This mixed‐matrix coating can successfully sense and inhibit bacterial contamination via a controlled release mechanism that is only triggered by bacteria. The system is coated on a common radiographic dental imaging device (photostimulable phosphor plate) that is prone to oral bacteria contamination. Variation and eventually disappearance of the red fluorescence surface under UV light signals bacterial infection. Kanamycin, an antimicrobial agent, is controllably released to instantly inhibit bacterial growth. Interestingly, the quality of the images obtained with these coated surfaces is the same as uncoated surfaces and thus the safe application of such smart coatings can be expanded to include other medical devices without compromising their utility.
Balancing the Benefits and Risks of CPR
Authors: Clifton W. Callaway, Karl B. Kern, Raina M. Merchant, Robert W. Neumar
Journal: The American Journal of Bioethics (2017)

The target article by Rosoff and Schneiderman (2017) raises the question of whether the training of laypersons to perform cardiopulmonary resuscitation (CPR) misrepresents the importance of laypers...
Over-Expression of the P65 Subunit of NF-kB and Increased DNA Binding Activity of NF-kB Is a Common Event Both in Philadelphia Positive and Negative Chronic Myeloproliferative Disorders.
Authors: Alessandro Morotti, Veronica Ullmannova, Daniela Cilloni, Francesca Messa, Manuela Messa, Ilaria Defilippi, Francesca Arruga, Sonia Carturan, Cedrik Haskovec, Enrico Gottardi, Giuseppe Saglio
Journal: Blood (2004)
5-Azacitidine in Combination with Donor Lymphocyte Infusions for the Treatment of Patients with MDS or AML Relapsing after Allogeneic Stem Cell Transplantation.
Authors: Akos Czibere, Thorsten Graef, Jens Lind, Norbert Gattermann, Fabian Zohren, Roland Fenk, Rainer Haas, Guido Kobbe
Journal: Blood (2006)
TCL1 Expression in Chronic Lymphocytic Leukemia Correlates with the Intensity of 11q Deletions and ZAP-70.
Authors: Laura Rassenti, L. Huynh, G.W. Basak, E.M. Ghia, D. Van Dyke, N. Heerema, D. Zahrieh, P. DalCin, M.L. Dell’Aquila, P. Koduru, J.C. Byrd, N.E. Kay, K.R. Rai, J.R. Brown, W.W. Wierda, A.W. Greaves, Thomas J. Kipps
Journal: Blood (2007)
Feasibility of Fecal Immunochemical Testing Among Hispanic and Haitian Immigrants Living in South Florida
Authors: Natasha Schaefer Solle, Daniel A. Sussman, Tulay Koru-Sengul, Julia Seay, Jordan Baeker-Bispo, Erin N. Kobetz
Journal: JAMA Internal Medicine (2017)

Melissa M. Parker, MS; Alicia Fernández, MD; Howard H. Moffet, MPH; Richard W. Grant, MD, MPH; Antonia Torreblanca, MD, MPH; Andrew J. Karter, PhD
A Novel Chemotherapy-Based Allogeneic Hematopoietic Stem Cell Transplant Regimen for Very Young Children with Leukemia.
Authors: Susan E. Prockop, Nancy A. Kernan, Elizabeth G Klein, Rachel Kobos, Andromachi Scaradavou, Trudy N. Small, Richard J. O'Reilly, Farid Boulad
Journal: Blood (2012)
Neurofilament Protein and Antineurofilament Antibodies Following Traumatic Brain Injury
Authors: Steve Kornguth
Journal: JAMA Neurology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Appropriate use of the EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis
Authors: AHM van der Helm-van Mil, RBM Landewé
Journal: Annals of the Rheumatic Diseases (2016)

Appropriate use of the EULAR definition of arthralgia suspicious for progression to rheumatoid arthritisWe thank Mankia et al 1 for their interest in the European League Against Rheumatism (EULAR) definition of arthralgia suspicious for progression to rheumatoid arthritis (RA). 2 The authors agree with the taskforce that derivation of criteria for imminent RA is an ambitious next step and that such criteria will probably consist of a combination of clinical, serological and imaging biomarkers. 1 In this light we appreciate the work the authors have done to identify serological and imaging markers that are predictive in patients with anti-citrullinated protein antibody (ACPA)-positive arthralgia.
DNA Damage Response and Repair Gene Alterations Are Associated with Improved Survival in Patients with Platinum-Treated Advanced Urothelial Carcinoma
Authors: Min Yuen Teo, Richard M. Bambury, Emily C. Zabor, Emmet Jordan, Hikmat Al-Ahmadie, Mariel E. Boyd, Nancy Bouvier, Stephanie A. Mullane, Eugene K. Cha, Nitin Roper, Irina Ostrovnaya, David M. Hyman, Bernard H. Bochner, Maria E. Arcila, David B. Solit, Michael F. Berger, Dean F. Bajorin, Joaquim Bellmunt, Gopakumar Iyer, Jonathan E. Rosenberg
Journal: Clinical Cancer Research (2017)

Purpose: Platinum-based chemotherapy remains the standard treatment for advanced urothelial carcinoma by inducing DNA damage. We hypothesize that somatic alterations in DNA damage response and repair (DDR) genes are associated with improved sensitivity to platinum-based chemotherapy.Experimental Design: Patients with diagnosis of locally advanced and metastatic urothelial carcinoma treated with platinum-based chemotherapy who had exon sequencing with the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT) assay were identified. Patients were dichotomized based on the presence/absence of alterations in a panel of 34 DDR genes. DDR alteration status was correlated with clinical outcomes and disease features.Results: One hundred patients were identified, of which 47 harbored alterations in DDR genes. Patients with DDR alterations had improved progression-free survival (9.3 vs. 6.0 months, log-rank P = 0.007) and overall survival (23.7 vs. 13.0 months, log-rank P = 0.006). DDR alterations were also associated with higher number mutations and copy-number alterations. A trend toward positive correlation between DDR status and nodal metastases and inverse correlation with visceral metastases were observed. Different DDR pathways also suggested variable impact on clinical outcomes.Conclusions: Somatic DDR alteration is associated with improved clinical outcomes in platinum-treated patients with advanced urothelial carcinoma. Once validated, it can improve patient selection for clinical practice and future study enrollment. Clin Cancer Res; 23(14); 3610-8. ©2017 AACR.
Monitoring Imatinib Resistance with a “Polony” Assay: Towards Tailored Therapy of Chronic Myelogenous Leukemia (CML).
Authors: Valentina Nardi, Tal Raz, Xinyu Chao, Catherine J. Wu, Richard Stone, Ilene Galinsky, Martha Wadleigh, Michael W.N. Deininger, George Church, Jun Zhu, George Q. Daley
Journal: Blood (2006)
Using economics to combat the tobacco disease epidemic
Authors: Kenneth E Warner
Journal: BMJ (2017)

New report is a must read for those charged with protecting the public health

A new publication, The Economics of Tobacco and Tobacco Control ,1 reminds us that “tobacco use remains the single largest preventable cause of death in the world.”

It is a reminder we need to contemplate seriously. Too many people in affluent countries think of tobacco as yesterday’s problem, one that, for all intents and purposes, has been solved. Smoking is no longer a factor in their lives. They don’t smoke. Their friends don’t smoke. They don’t see it in their workplaces, or in the places where they dine and drink. Yet a billion of their fellow citizens continue to light up daily. Of lifetime smokers, half will die as a result, losing 20 years of life expectancy on average.2

Worldwide, nearly six trillion cigarettes are consumed annually, and they kill six million people each year, a number that will grow …
Distinct Human Cell Populations Produce Rapidly Detectable Levels of Neutrophils and Platelets in NOD/SCID-IL-2Receptor Gamma Chain Null Mice Transgenically Engineered to Produce Human Myeloid Growth Factors
Authors: Paul H. Miller, Alice M.S. Cheung, Suzan Imren, Philip A Beer, Shabnam Rostamirad, Kiran Dhillon, R. Keith Humphries, Connie J. Eaves
Journal: Blood (2011)
Preliminary Results of the Addition of Rasburicase to the Reduction Cycle and Rituximab to the Induction and Consolidation Cycles of FAB Group C Chemotherapy in Children and Adolescents with Advanced Stage (Bone Marrow ±CNS) Mature B-Cell Non-Hodgkin Lymphoma (B-NHL): A Children's Oncology Group Report.
Authors: Stanton Goldman, James Lynch, Lauren Harrison, Thomas Gross, Bruce Shiramizu, Warren Sanger, Sherrie L. Perkins, Mitchell S. Cairo
Journal: Blood (2009)
A missense variant in NCF1 is associated with susceptibility to multiple autoimmune diseases
Authors: Jian Zhao, Jianyang Ma, Yun Deng, Jennifer A Kelly, Kwangwoo Kim, So-Young Bang, Hye-Soon Lee, Quan-Zhen Li, Edward K Wakeland, Rong Qiu, Mengru Liu, Jianping Guo, Zhanguo Li, Wenfeng Tan, Astrid Rasmussen, Christopher J Lessard, Kathy L Sivils, Bevra H Hahn, Jennifer M Grossman, Diane L Kamen, Gary S Gilkeson, Sang-Cheol Bae, Patrick M Gaffney, Nan Shen, Betty P Tsao
Journal: Nature Genetics (2017)
Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies
Authors: Roby Joehanes, Xiaoling Zhang, Tianxiao Huan, Chen Yao, Sai-xia Ying, Quang Tri Nguyen, Cumhur Yusuf Demirkale, Michael L. Feolo, Nataliya R. Sharopova, Anne Sturcke, Alejandro A. Schäffer, Nancy Heard-Costa, Han Chen, Po-ching Liu, Richard Wang, Kimberly A. Woodhouse, Kahraman Tanriverdi, Jane E. Freedman, Nalini Raghavachari, Josée Dupuis, Andrew D. Johnson, Christopher J. O’Donnell, Daniel Levy, Peter J. Munson
Journal: Genome biology (2017)

Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as expression quantitative trait loci (eQTLs), may improve understanding of the functional role of phenotype-associated SNPs in genome-wide association studies (GWAS). The small sample sizes of some previous eQTL studies have limited their statistical power. We conducted an eQTL investigation of microarray-based gene and exon expression levels in whole blood in a cohort of 5257 individuals, exceeding the single cohort size of previous studies by more than a factor of 2.We detected over 19,000 independent lead cis-eQTLs and over 6000 independent lead trans-eQTLs, targeting over 10,000 gene targets (eGenes), with a false discovery rate (FDR) < 5%. Of previously published significant GWAS SNPs, 48% are identified to be significant eQTLs in our study. Some trans-eQTLs point toward novel mechanistic explanations for the association of the SNP with the GWAS-related phenotype. We also identify 59 distinct blocks or clusters of trans-eQTLs, each targeting the expression of sets of six to 229 distinct trans-eGenes. Ten of these sets of target genes are significantly enriched for microRNA targets (FDR < 5%). Many of these clusters are associated in GWAS with multiple phenotypes.These findings provide insights into the molecular regulatory patterns involved in human physiology and pathophysiology. We illustrate the value of our eQTL database in the context of a recent GWAS meta-analysis of coronary artery disease and provide a list of targeted eGenes for 21 of 58 GWAS loci.
ACC/AHA Special Report: Clinical Practice Guideline Implementation Strategies: A Summary of Systematic Reviews by the NHLBI Implementation Science Work Group
Authors: Wiley V. Chan, Thomas A. Pearson, Glen C. Bennett, William C. Cushman, Thomas A. Gaziano, Paul N. Gorman, Joel Handler, Harlan M. Krumholz, Robert F. Kushner, Thomas D. MacKenzie, Ralph L. Sacco, Sidney C. Smith, Victor J. Stevens, Barbara L. Wells
Journal: Journal of the American College of Cardiology (2017)
厚朴中のマグノロール,ホノキオール及びβ‐オイデスモール含量の品種間及び地理的変動,及びその含量と形態特性の相関
Authors: Kondo K, Hattori N, Kidoguchi K, Sakakibara I, Terabayashi S, Okada M, Shu G‐M, Xu X‐M, Liu X‐Z
Journal: Nature Medicine (2000)
Sitting behaviour is not associated with incident diabetes over 13 years: the Whitehall II cohort study
Authors: Emmanuel Stamatakis, Richard M Pulsford, Eric J Brunner, Annie R Britton, Adrian E Bauman, Stuart JH Biddle, Melvyn Hillsdon
Journal: British Journal of Sports Medicine (2017)

Although certain types of sedentary behaviour have been linked to metabolic risk, prospective studies describing the links between sitting with incident diabetes are scarce and often do not account for baseline adiposity. We investigate the associations between context-specific sitting and incident diabetes in a cohort of mid-aged to older British civil servants.Using data from the Whitehall II study (n=4811), Cox proportional hazards models (adjusted for age, sex, ethnicity, employment grade, smoking, alcohol intake, fruit and vegetable consumption, self-rated health, physical functioning, walking and moderate-to-vigorous physical activity, and body mass index (BMI)) were fitted to examine associations between total sitting and context-specific sitting time (work, television (TV), non-TV leisure time sitting at home) at phase 5 (1997-1999) and fasting glucose-defined incident diabetes up to 2011.Total sitting (HR of the top compared with the bottom group: 1.26; 95% CI 1.00 to 1.62; p=0.01) and TV sitting (1.33; 95% CI 1.03 to 1.88; p=0.05) showed associations with incident diabetes; once BMI was included in the model these associations were attenuated for both total sitting (1.19; 95% CI 0.92 to 1.55; p=0.22) and TV sitting (1.31; 95% CI 0.96 to 1.76; p=0.14).We found limited evidence linking sitting and incident diabetes over 13 years in this occupational cohort of civil servants.
Clinical-Scale Genome Editing of the Human BCL11A Erythroid Enhancer for Treatment of the Hemoglobinopathies
Authors: Fyodor D Urnov, Andreas Reik, Jeff Vierstra, Kai-Hsin Chang, Yuanyue Zhou, Andrea Mich, Jennifer Adrian, Lisa Fox, Nikoletta Psatha, Siyuan Tan, Evangelia Yannaki, Stewart Craig, Edward J. Rebar, John Stamatoyannopoulos, Thalia Papayannopoulou, George Stamatoyannopoulos, Haiyan Jiang
Journal: Blood (2015)
Role of topotecan, vinorelbine, thiotepa, and gemcitabine (TVTG) chemotheapy in relapsed/refractory adult acute leukemia: A single-institution retrospective analysis.
Authors: S. A. Srour, M. A. Cherry, E. Borders, H. Parekh, J. L. Holter, T. S. Herman, G. B. Selby
Journal: Journal of Clinical Oncology (2011)

6603 Background: Patients with multiply relapsed or refractory acute leukemia (R/R-AL) have very limited treatment options and dismal prognosis. Limited data is available about the role of TVTG in adult patients with acute leukemia (AML or ALL). Our report is the largest retrospective analysis of TVTG in this population. Methods: From 2004 to 2010 we identified 18 patients (pts) with R/R-AL received TVTG regimen (Table). Primary end points were complete response (CR) rate and the rate of pts reaching allogeneic transplant (allo-SCT). Secondary end points included partial response (PR) and grade 3-4 adverse events (AE) rates. CR was defined as <5% blasts in the bone marrow (BM) and PR as 5-25%, each with recovery of peripheral counts. PRa was defined as BM aplasia/hypoplasia with <5% blasts, but without hematopoietic recovery. Results: Of the 18 pts (12 male) who received TVTG, 15 had AML (11 relapsed) and 3 had ALL (pre-B-cell type, 2 relapsed). Median age at initial diagnosis was 45.5 years (19-63), and median age at treatment with TVTG was 46.5 years. All received gemcitabine on day 7 except 1 pt (Table). Overall response rate (CR, PR, PRa) was 33% (6 pts). Four pts (22%) achieved CR. In AML pts, 2 out of 15 had CR (13%), 1 had PR (7%) and 1 had PRa (7%). In ALL pts, 2 out of 3 achieved CR (67%). A total of 4 pts (22%) proceeded to allo-SCT; 3 while in CR after TVTG. The median time from CR to transplant was 4 weeks. 7 out of 18 pts died within 6 weeks of therapy of which 4 (28%) died within 30 days; deaths were attributed to severe infections and/or refractory disease. Hematologic and infectious AE were almost universal. Other common grade 3-4 AE included hyperbilirubinemia in 8 pts (44%) and diarrhea in 6 pts (33%). Conclusions: In heavily pretreated adult R/R-AL pts, TVTG is a reasonable option for ALL as salvage therapy prior to allo-SCT. The benefit in AML pts is less defined, with high AE and therapy-related mortality rates. New therapies are warranted for R/R-AL. Dose Day Topotecan 1 mg/m2 IV 1-5 Vinorelbine 20 mg/m2 IV 0, 7, 14, 21 Thiotepa 15 mg/m2 IV 2 Gemcitabine 3600 mg/m2 IV over 6 hours 7 (held for day 7 BM <5% blasts) Dexamethasone 45 mg/m2 PO 7-14 G-CSF 5 mcg/kg/day SC 7 (until ANC >500)
DNMT3A Mutations Associate with Shorter Survival and Modulate the Prognostic Impact of Mutated NPM1: an Analysis Based on Comprehensive Mutational Screening of 660 AML Patients Treated on German AML Cooperative Group (AMLCG) Trials
Authors: Klaus H. Metzeler, Tobias Herold, Maja Rothenberg-Thurley, Susanne Amler, Cristina Sauerland, Stephanie Schneider, Nikola P Konstandin, Annika Maria Dufour, Kathrin Bräundl, Bianka Ksienzyk, Evelyn Zellmeier, Luise Hartmann, Philipp A. Greif, Michael Fiegl, Marion S. Subklewe, Stefan K. Bohlander, Utz Krug, Wolfgang E Berdel, Bernhard Wörmann, Thomas Büchner, Andreas Faldum, Wolfgang Hiddemann, Jan Braess, Karsten Spiekermann
Journal: Blood (2015)
A Relapse Risk Score to Predict Acute Myeloid Leukemia Relapse After Nonmyeloablative Allogeneic Hematopoietic Cell Transplantation Based on Pre-Transplant Variables.
Authors: Boglarka Gyurkocza, Rainer Storb, Barry E. Storer, Thomas Chauncey, Thoralf Lange, Ginna G. Laport, Amelia Langston, Michael A. Pulsipher, Christopher Bredeson, Richard Maziarz, Benedetto Bruno, Finn Petersen, Michael Maris, Edward Agura, Andrew M. Yeager, Wolfgang A. Bethge, Firoozeh Sahebi, Frederick R. Appelbaum, David G. Maloney, Elihu H. Estey, Brenda M. Sandmaier
Journal: Blood (2010)
Detection of Copy Number Alterations in DNA Repair/Repair-Related Genes for a Diversity of Hematologic Malignancies Identifies Disease-Specific Biomarkers of Potential Clinical Relevance.
Authors: Roger A Schultz, Theresa C. Brown, Lynda J Campbell, Meaghan Wall, Jacqueline Schoumans, Jin-Yeong Han, Urvashi Surti, S. Dwanna Stewart, Min Fang, James M Fink, Raymond R. Tubbs, James R. Cook, Elena Gitelson, Lisa D McDaniel, Lisa G Shaffer, Blake C Ballif
Journal: Blood (2012)
Interim Analysis of a Phase II Study of the Combination of Denileukin Diftitox (Ontak) and Rituximab for Relapsed/Refractory B-Cell Non-Hodgkin’s Lymphoma.
Authors: Nam H. Dang, Peter McLaughlin, Luis Fayad, Jorge Romaguera, Fredrick Hagemeister, Anas Younes, Sattva Neelapu, Felipe Samaniego, Dan Jones, Pamela L. Walker, Maria A. Rodriguez, Larry Kwak, Barbara Pro
Journal: Blood (2005)
Antibiotic therapy prior to hospital admission is associated with reduced septic shock and need for mechanical ventilation in patients with community-acquired pneumonia
Authors: Rosanel Amaro, Jacobo Sellarés, Eva Polverino, Catia Cillóniz, Miquel Ferrer, Laia Fernández-Barat, Josep Mensa, Michael S. Niederman, Antoni Torres
Journal: Journal of Infection (2017)