tbuckley/cabot-search huggingface dataset:
Psychological distress and natural killer cells in gay men with and without HIV infection
Authors: J A Sahs, R Goetz, M Reddy, J G Rabkin, J B Williams, R Kertzner, J M Gorman
Journal: American Journal of Psychiatry (1994)

The variability of the decline in immune function among those infected by HIV raises the possibility that psychological factors might help to explain the differences. Since studies of other populations have shown natural killer (NK) cells to be affected by psychiatric conditions, the authors examined this relationship in the context of HIV infection, expecting to find fewer NK cells to be associated with greater psychological distress.Forty-six HIV-negative and 74 HIV-positive gay men who were participating in a longitudinal study had NK cells enumerations performed (by staining for CD56) 36 months after entry into the study. Comparisons were made between HIV-negative, HIV-positive asymptomatic, and HIV-positive symptomatic men by using a variety of clinician-rated and self-report measures of psychological function and absolute NK cell number.HIV-negative men had more NK cells than the groups of HIV-positive men. The groups' measures of psychological distress did not differ in any clinically meaningful ways. In general, the presence of DSM-III-R diagnoses and the measures of distress did not relate to NK cell number.NK cell number is not related to measures of psychological distress in these gay men with and without HIV infection.
Abstract P1-12-07: Delayed initiation of adjuvant chemotherapy among breast cancer patients: A population-based study
Authors: M Chavez-MacGregor, CA Clark, DY Lichetensztajn, SH Giordano
Journal: Cancer Research (2016)

Abstract BACKGROUND: Adjuvant chemotherapy improves outcomes of breast cancer patients; however the optimal timing to initiation of chemotherapy remains unknown. No study has evaluated the relationship between time to chemotherapy (TTC) and outcome in a population-based study of patients treated with contemporary regimens according to tumor subtype. In this large study we identified the determinants associated with a delay in the initiation of chemotherapy and determined whether TTC is related to outcome. METHODS: Breast cancer patients diagnosed with stage I-III breast cancer between 2005-2010 and treated with adjuvant chemotherapy were identified in the California Cancer Registry. TTC was defined as number of days between surgery and the day the first dose of adjuvant chemotherapy was administered. Delayed TTC was defined as &amp;gt;91 days. Logistic regression and Cox-proportional hazard modeling were used. RESULTS: A total of 24,843 patients were included. Factors associated with delays in TTC included low socioeconomic status, reconstructive surgical procedure, non-private insurance and Hispanic or non-Hispanic black race/ethnicity. Compared to patients receiving chemotherapy within 31 days from surgery, there was no evidence of adverse outcome among those with TTC of 31-60 or 60-90 days. To the contrary, patients treated &amp;gt;91 days from surgery experienced statistically significant worse overall survival (OS) (HR=1.34; 95%CI 1.15-1.57) and worse breast cancer specific survival (BCSS) (HR=1.27; 95%CI 1.05-1.53). In a subgroup analysis according to breast cancer subtype, TTC &amp;gt;91 days had a statistically significant detrimental impact among patients with triple negative breast cancer (TNBC) in terms of both OS (HR=1.53; 95%CI 1.17-2.00) and BCSS (HR=1.53; 95%CI 1.17-2.07). CONCLUSIONS: In this large cohort of breast cancer patients treated with contemporary regimens, a delaying in the initiation of adjuvant chemotherapy &amp;gt;91 days was associated with adverse outcomes. A delay in TTC is particularly detrimental among patients with TNBC. The majority of the determinants of delays in chemotherapy initiation are socio-demographic in nature. As medical providers we must make every effort to provide timely care to all our patients so they can receive the full benefit of our current treatments. Citation Format: Chavez-MacGregor M, Clark CA, Lichetensztajn DY, Giordano SH. Delayed initiation of adjuvant chemotherapy among breast cancer patients: A population-based study. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-12-07.
Hematological effects of carbamazepine in patients with affective illness
Authors: R T Joffe, R M Post, P P Roy-Byrne, T W Uhde
Journal: American Journal of Psychiatry (1985)

The hematological effects of carbamazepine, a drug effective in the acute and prophylactic treatment of manic-depressive disorder, were assessed in 43 subjects with affective disorder. Carbamazepine was found to cause statistically significant, but clinically insubstantial, decreases in white blood cell indexes. The consistent decreases in white cell counts observed with carbamazepine should be differentiated from the extremely rare, idiosyncratic blood dyscrasias reported in the literature.
Abstract P5-01-06: 18F-radiolabeled PARP-1 inhibitor uptake as a marker of PARP-1 activity in breast cancer
Authors: CE Edmonds, BP Lieberman, K Xu, C Zeng, M Makvandi, S Li, C Hou, H Lee, RA Greenberg, DA Mankoff, RH Mach
Journal: Cancer Research (2016)

Abstract Objectives: The nuclear enzyme PARP-1 plays a central role in sensing DNA damage and facilitating repair. Tumors with BRCA1/2 mutations are highly dependent on PARP-1 as an alternative mechanism for DNA repair, and PARP inhibitors generate synthetic lethality in tumors with BRCA mutations, resulting in cell cycle arrest and apoptosis. Zhou et al. recently synthesized an 18F-labeled PARP-1 inhibitor (18F-FluorThanatrace) for PET, and demonstrated high specific tracer uptake in a xenograft model of breast cancer (Zhou, Bioorg Med Chem, 22:1700, 2014). The current study seeks to quantify the relationship between 18F-FluorThanatrace binding (both in vitro and on PET imaging of human tumor xenografts) and the level of constitutively active PARP-1, using multiple human breast cancer cell lines, including a BRCA1 defective line. Methods: BRCA1 defective HCC1937, triple negative MDA-MB-231, and luminal A MCF-7 human breast cancer lines were assessed for constitutive PARP-1 activity via a chemiluminescent ELISA assay for PAR and by Western blot. The same cell lines were incubated with 18F-FluorThanatrace over various time increments, and tracer uptake was assayed via a gamma counter. Specificity of tracer binding was verified via co-incubation with competitive inhibitor Olaparib, and specific tracer uptake was calculated as the difference between uptake with and without Olaparib. Specific tracer uptake was compared to levels of constitutive PARP-1 activity in all cell lines. In addition, HCC1937 and MDA-MB-231 xenograft tumor models were imaged via 18F-FluorThanatrace-PET/CT, and PET uptake was correlated with PARP-1 activity. Results: BRCA1-defective HCC1937 had higher constitutive PARP-1 activity than cell lines with intact BRCA1. In vitro levels of 18F-FluorThanatrace uptake correlated with constitutive PARP-1 activity across cell lines. In addition, 18F-FluorThanatrace measured by PET in xenograft breast cancer tumor models correlated with constitutive PARP-1 activity. Conclusions: Tumor uptake of 18F-FluorThanatrace, both in vitro and on PET imaging of xenograft tumor models, quantitatively reflects differences in PARP-1 activity across different breast cancer cell lines, including BRCA1 defective. This motivates further studies of 18F-FluorThanatrace as an in vivo measure of PARP-1 activity and possibly as a predictive marker for PARP-1 therapy in patients, including those with BRCA1/2 mutations. Citation Format: Edmonds CE, Lieberman BP, Xu K, Zeng C, Makvandi M, Li S, Hou C, Lee H, Greenberg RA, Mankoff DA, Mach RH. 18F-radiolabeled PARP-1 inhibitor uptake as a marker of PARP-1 activity in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-01-06.
A phase I/II study of intravenous Rexin-G and Reximmune-C for cancer immunotherapy: The GeneVieve protocol.
Authors: J. G. Ignacio, S. P. Chawla, R. E. Manalo, L. Baniqued, F. S. San Juan, A. Madamba, F. L. Hall, E. M. Gordon
Journal: Journal of Clinical Oncology (2010)

2546 Background: Rexin-G (R-G) and Reximmune-C (R-C) are tumor-targeted retrovectors bearing a cytocidal cyclin G1 “knockout” construct and a controllable GM-CSF expression construct, respectively. The hypothesis underlying this two-pronged approach is that the personalized vaccination of a patient against his/her own specific cancer can be achieved by combining (1) a targeted vector bearing a tumoricidal payload, i.e., R-G with (2) a targeted vector bearing a potent immunostimulatory gene, i.e., R-C. Purpose: To evaluate the safety and potential antitumor activity of intravenous infusions of R-G followed by Reximmune-C pulses in chemoresistant solid tumors. Methods: All patients with chemoresistant pancreas cancer (n=2), colon cancer (n=2), breast cancer (n=1), ovarian cancer (n=1), Ewing's sarcoma (n=1), or prostate cancer (n=1) had achieved a partial response (PR) or stable disease (SD) with prior R-G monotherapy. Eight patients received R-G, 2 × 10e11 cfu on days 1, 3, and 5, plus R-C, 0.5 or 1.0 × 10e10 cfu (dose I or II respectively) on day 3, and valacyclovir at 3 gms/day p.o. on days 6-19, comprising one cycle. Treatment cycles were repeated up to 6 cycles, if there was ≤grade 1 toxicity. Results: There were no treatment-related adverse events. Table below shows the tumor responses, progression-free survival (PFS), and overall survival (OS) of treated patients. Histopathologic examination of a resected indicator cervical lymph node following treatment showed complete effacement of the lymph node architecture by tumor-infiltrating lymphocytes. Conclusions: These findings indicate that the GeneVieve protocol is safe and well-tolerated and that this strategic combination of R-G plus Reximmune-C may help control tumor growth and prolong survival—advancing personalized cancer vaccination as a realistic goal. Reximmune-C dose level Tumor response by RECIST Median PFS by RECIST (months) Median OS (months from start of R-G treatment) I (n=5) 1 PR, 3 SD, 1 PD > 9 > 10 II (n=3) 1 PR, 2 SD > 6 > 8 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Epeius Biotechnologies Epeius Biotechnologies Epeius Biotechnologies Epeius Biotechnologies
Mood disorders in left-handed stroke patients
Authors: R G Robinson, J R Lipsey, K Bolla-Wilson, P L Bolduc, G D Pearlson, K Rao, T R Price
Journal: American Journal of Psychiatry (1985)

Thirty left-handed patients hospitalized for stroke were examined for mood disorders. Patients with left hemisphere lesions and nondominant hand impairments had significantly higher depression scores and more depressive diagnoses than patients with right hemisphere lesions and dominant hand impairments. Major depression was strongly associated with left anterior brain injury, and depression severity was significantly correlated with proximity of the lesion on CAT scan to the left frontal pole. These findings are almost identical to previously reported results from right-handed patients and suggest that cerebral lateralization of poststroke mood disorders may be independent of cerebral motor dominance and language dominance.
Over-the-scope clip for a pharyngeal perforation caused by a self-inflicted stab wound to the neck
Authors: Federico Iacopini, Marc Schurr, Guido Costamagna, Agostino Scozzarro
Journal: Endoscopy (2014)

An 86-year-old woman was admitted to the emergency room with a self-inflicted 3-cm horizontal wound to the left lateral side of her neck between the cricoid inferiorly and the angle of the mandible superiorly. Pain, tenderness, and bloody saliva suggested a penetrating zone II neck perforation [1]. No signs of significant injury, such as severe active hemorrhage, bruit, pulse deficit, hoarseness, stridor, respiratory distress, hemiparesis, expanding hematoma, or subcutaneous emphysema, were observed clinically or found on computed tomography (CT) scanning.
Streptococcus pneumoniae nasopharyngeal colonisation in children aged under six years with acute respiratory tract infection in Lithuania, February 2012 to March 2013
Authors: V Usonis, I Stacevičienė, S Petraitienė, D Vaičiūnienė, T Alasevičius, J Kirslienė
Journal: Eurosurveillance (2015)

Data on distribution of Streptococcus pneumoniae (SPn) serotypes among children in Lithuania are limited. A prospective study was carried out from February 2012 to March 2013 to evaluate the circulation of SPn serotypes among young children in five cities of Lithuania before the introduction of universal vaccination with pneumococcal conjugate vaccine (PCV). A total of 900 children under six years of age who presented to primary care centres or a hospital emergency department with acute respiratory tract infection (RTI) were enrolled in the study. The SPn colonisation rate was 40.8% (367/900), with a peak at two and three years-old (48.8% and 45.4%, respectively). Of the 367 SPn isolates, the most common serotypes were 6B (15.8%, n = 58), 19F (13.9%, n = 51), 23F (13.9%, n = 51), 15 (10.1%, n = 37), 14 (9.5%, n = 35), 6A (9.3%, n= 34), 11 (4.6%, n = 17), 3 (3.0%, n = 11) and 18C (3.0%, n = 11); less frequent were 23 (non-23F) (2.7%, n = 10), 19A (2.2%, n = 8) and 9V (1.6%, n = 6). Serotypes 6A and 11 were more common in children under two years-old; 18C was found only in children aged two to five years. The serotypes found might be an important predictor of the likely effectiveness of the PCVs currently available in Lithuania.
Sodium in Store and Restaurant Food Environments — Guam, 2015
Authors: Sandra L. Jackson, Brenna K. VanFrank, Elizabeth Lundeen, Alyssa Uncangco, Lawrence Alam, Sallyann M. Coleman King, Mary E. Cogswell
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Compared with the United States overall, Guam has higher mortality rates from cardiovascular disease and stroke (1). Excess sodium intake can increase blood pressure and risk for cardiovascular disease (2,3). To determine the availability and promotion of lower-sodium options in the nutrition environment, the Guam Department of Public Health and Social Services (DPHSS) conducted an assessment in September 2015 using previously validated tools adapted to include sodium measures. Stores (N = 114) and restaurants (N = 63) were randomly sampled by region (north, central, and south). Data from 100 stores and 62 restaurants were analyzed and weighted to account for the sampling design. Across the nine product types assessed, lower-sodium products were offered less frequently than regular-sodium products (p<0.001) with <50% of stores offering lower-sodium canned vegetables, tuna, salad dressing, soy sauce, and hot dogs. Lower-sodium products were also less frequently offered in small stores than large (two or more cash registers) stores. Reduced-sodium soy sauce cost more than regular soy sauce (p<0.001) in stores offering both options in the same size bottle. Few restaurants engaged in promotion practices such as posting sodium information (3%) or identifying lower-sodium entrées (1%). Improving the availability and promotion of lower-sodium foods in stores and restaurants could help support healthier eating in Guam.
A motion artifact on a gastrointestinal bleeding scan mimicking a second axillary-femoral arterial bypass graft.
Authors: DINESH BHAMBHVANI, DARLENE FINK-BENNETT
Journal: Clinical Nuclear Medicine (2001)

From the William Beaumont Hospital, Department of Nuclear, Medicine, Royal Oak, Michigan Received for publication July 5, 2000. Revision accepted October 5, 2000. Reprint requests: Darlene Fink-Bennett, M.D., Department of Nuclear Medicine, William Beaumont Hospital, 3601 West Thirteen Mile Road, Royal Oak, Michigan 48073. E-mail: [email protected]
CSF monoamine metabolites in depression and schizophrenia
Authors: P A Berger, K F Faull, J Kilkowski, P J Anderson, H Kraemer, K L Davis, J D Barchas
Journal: American Journal of Psychiatry (1980)

The authors report cerebrospinal fluid (CSF) concentrations of five monoamine metabolites before and after probenecid administration in normal subjects and patients with depression and schizophrenia. No differences were found in baseline metabolite concentrations among the three groups. CSF metabolite and CSF probenecid concentrations were significantly correlated in depressed patients for all metabolites, and there was decreased postprobenecid accumulation of homovanillic acid in the CSF of depressed patients compared with schizophrenic patients and with normal subjects. The authors propose a method for correcting for probenecid concentrations. Data from normal subjects should be of value for other investigators using the probenecid technique.
Tamsulosin 0.4 mg Once Daily: Tolerability in Older and Younger Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Obstruction (Symptomatic BPH)
Authors: C R Chapple, L Baert, P Thind, K Höfner, G S Khoe, A Spångberg
Journal: European Urology (1997)
Calcium Disodium Edathamil in the Treatment of Ferrous Sulfate Poisoning
Authors: Herbert Barrie
Journal: JAMA (1962)

ACHELATING AGENT is a compound which binds with a heavy metal to give a harmless water soluble product which may then be readily excreted (chela = claw). Calcium disodium edathamil, also known as E.D.T.A. and ethylene diamine tetraacetic acid, (hereafter referred to as edathamil) is the best known of these agents and the value of its calcium disodium salt in the treatment of lead poisoning has been substantiated by many reports (Byers, 1954). Claims for its effectiveness in other forms of metal poisoning have also been made, including hypercalcemia, calcinosis, mercury poisoning, hemochromatosis, and the removal of radium plutonium and fission products. In the case of acute iron poisoning, its use is comparatively little-known and there are only a few reports of patients successfully treated with this substance. This is a matter for concern since iron is a common accidental poison in childhood and carries a high mortality. The widespread
Sex bias in psychotherapy: a failure to confirm
Authors: S I Abramowitz, H B Roback, J M Schwartz, A Yasuna, C V Abramowitz, B Gomes
Journal: American Journal of Psychiatry (1976)

The authors examined the questions of sex-related countertransference and bias in psychotherapy by asking 65 male and 57 female experienced group therapists for clinical reactions to case materials of a bogus outpatient who was designated either male or female. They found that varying the patient's gender produced only small differences in the therapists' responses, and conclude that sex-related countertransference problems may not be as prevalent as had been previously thought.
Activation Status and Prognostic Significance of the Wnt/B Catenin and Hedgehog/Smoothened Signalling Pathways in Patients with Cancer of Unknown Primary (Cup): a Translational Research Study of the Hellenic Cooperative Oncology Group (Hecog)
Authors: G. Pentheroudakis, G. Fotopoulos, A. Gousia, M. Bobos, S. Chrysafi, G. Fountzilas, N. Pavlidis
Journal: Annals of Oncology (2014)
A linear quadratic analysis of differing fractionation schemes for prophylactic cranial irradiation.
Authors: S H Krosnick, D E Wazer
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.9.1599 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2391560 A linear quadratic analysis of differing fractionation schemes for prophylactic cranial irradiation. S H KrosnickxS H KrosnickSearch for articles by this author , D E WazerxD E WazerSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.9.1599 PDF "A linear quadratic analysis of differing fractionation schemes for prophylactic cranial irradiation.." Journal of Clinical Oncology, 8(9), pp. 1599–1600© 1990 by American Society of Clinical Oncology
Abstract PD7-02: Multiplex Identification of genetic etiologies among women with bilateral breast cancer using a 25-gene hereditary cancer panel
Authors: JN Weitzel, KR Blazer, B Nehoray, J Kidd, TP Slavin, I Solomon, M Niell-Swiller, C Rybak, J Saam, J Lancaster
Journal: Cancer Research (2016)

Abstract Background: Multiple primary cancers within an individual is one of the hallmarks of hereditary cancer predisposition. Technical advances in sequencing and identification of additional cancer susceptibility genes have led to multi-gene panel approaches to determine if patient cancers have a heritable cause. Simultaneous testing of multiple breast cancer associated genes to determine the prevalence, spectrum and combinations of mutations has not yet been evaluated in a large set of patients with two breast cancers. Methods: Patients with two breast cancer diagnoses were identified from 80,748 consecutive cases that underwent a 25-gene hereditary cancer panel test at a commercial diagnostic laboratory. Patient clinical data were obtained by healthcare provider report on test requisition forms. Results: Of 3,182 patients with two breast cancers, 13.3 % (n=424) had a pathogenic variant (PV) in at least one of 19 genes on the panel. PVs were most prevalent within BRCA1, representing 26.3% of the PVs, followed by BRCA2 (21.9%), CHEK2 (13.5%), PALB2 (11%) and ATM (11%). Fourteen patients had PVs in two different genes, including five with CHEK2/PALB2 in combination, which was the only combination observed more than once. PVs were more common among the 33.8% of patients with synchronous breast cancers compared to those with metachronous diagnoses (10.8% vs. 15%) and in the 58.4% who were first diagnosed younger than 50 years old (15.7% vs. 10%). Conclusion: Multiplex testing in women with two primary breast cancers identifies a relatively high percentage with a PV, including those whose first diagnosis was older than 50. While still the most prevalent and clear cause, fewer than half of the PVs identified were in BRCA1 or BRCA2. The observation of 5 cases with double CHEK2/PALB2 PVs is statistically unexpected given their individual prevalence in other studies of high risk women with breast cancer, suggesting a possible synergistic or additive effect. This study adds to our understanding of susceptibility to multiple primary breast cancers, and reaffirms the importance of this circumstance as a prompt for genetic testing. Nonetheless, as 66% of cases had metachronous tumors, it would be preferable to identify those at risk with heritable cancer syndromes at their first diagnosis and enable subsequent prevention or early detection. Citation Format: Weitzel JN, Blazer KR, Nehoray B, Kidd J, Slavin Jr TP, Solomon I, Niell-Swiller M, Rybak C, Saam J, Lancaster J. Multiplex Identification of genetic etiologies among women with bilateral breast cancer using a 25-gene hereditary cancer panel. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr PD7-02.
Effect of Catecholamines on Energy Metabolism of Myocardium
Authors: Toru Yamagami, Nobuhiko Shibata, Hirotaka Akagami
Journal: Circulation (1971)

The effects of catecholamines on the oxidative phosphorylation of mitochondria and superprecipitation of myosin B was studied. Mitochondrial oxidative phosphorylations was inhibited by catecholamines. But super-precipitation of myosin B was activated by isoproterenol when the superprecipitation was inhibited by the microsomal fraction.