tbuckley/cabot-search huggingface dataset:
The OHRP and SUPPORT — Another View
Authors: Ruth Macklin, Lois Shepherd, Alice Dreger, Adrienne Asch, Francoise Baylis, Howard Brody, Larry R. Churchill, Carl H. Coleman, Ethan Cowan, Janet Dolgin, Jocelyn Downie, Rebecca Dresser, Carl Elliott, M. Carmela Epright, Ellen K. Feder, Leonard H. Glantz, Michael A. Grodin, William Hoffman, Barry Hoffmaster, David Hunter, Ana S. Iltis, Jonathan D. Kahn, Nancy M.P. King, Rory Kraft, Rebecca Kukla, Lewis Leavitt, Susan E. Lederer, Trudo Lemmens, Hilde Lindemann, Mary Faith Marshall, Jon F. Merz, Frances H. Miller, Margaret E. Mohrmann, Haavi Morreim, Meryl Nass, James L. Nelson, John H. Noble, Elizabeth Reis, Susan M. Reverby, Anita Silvers, Aron C. Sousa, Roy G. Spece, Carson Strong, Judith P. Swazey, Leigh Turner
Journal: New England Journal of Medicine (2013)

Section A: The nature, duration and purpose of study.Your child is invited to participate in a single follow-up visit between the age of six years, four months and seven years, two months of age (school age) for children who were enrolled in the SUPPORT MRI study.As you may recall, that study did an extra brain ultrasound at the time that your child's near-term brain MRI was done for routine care.The purpose was to compare the findings of early and near-term ultrasounds and near-term MRI to determine if one way of imaging gives more useful information than the other.The primary purpose of the study is to examine the children at school age and determine whether near-term MRI is better than ultrasound in predicting developmental outcome.The second purpose is to evaluate the weight, height, body measurements and blood pressure.During the clinic visit, the interviews for you as a parent will take about 1 ½ -2 hours and the time to evaluate your child will take about 3½ hours, including breaks.The interviews with you will be at the same time your child is being tested so the whole visit will last about 3½ hours.SUPPORT school age follow-up, funded by the National Institutes of Health, is being conducted at Women and Infants Hospital and 14 other medical centers across the country.About 500 children and their parents are expected to participate.Sixty-one children are eligible to participate at Women and Infants Hospital.
The Molecular Biology of Human Immunodeficiency Virus Type 1 Infection
Authors: W C Greene
Journal: New England Journal of Medicine (1991)

HUMAN immunodeficiency virus type 1 (HIV-1) has been clearly identified as the primary cause of the acquired immunodeficiency syndrome (AIDS).1 , 2 Unlike any other infectious disease in modern medical history, AIDS has galvanized the concern and efforts of physicians, scientists, and the lay public alike. The magnitude of the mounting AIDS problem is indeed sobering. Since the initial clinical reports in the summer of 1981, over 132,000 cases of AIDS have been diagnosed in the United States, and nearly half the patients have died as a result of their disease.3 In addition, between 1 and 2 million Americans are now infected . . .
Tracheoesophageal Fistula in a Newborn
Authors: Munevver Uluba, Sabriye Dayi
Journal: New England Journal of Medicine (2014)

Tracheoesophageal Fistula in a NewbornA full-term baby girl had choking, cyanosis, and seizures after the first feeding, 2 hours after birth. The mother had had preeclampsia and oligohydramnios during pregnancy. A tracheoesophageal fistula was identified in the infant; a video is available at NEJM.org.
Tc-99m N2S2 MoAb FRAGMENTS: CLEARANCE, EXCRETION AND URINARY METABOLITE ANALYSIS IN PATIENTS.
Authors: R. W. Schroff, S. L. Johnson, A. R. Fritzberg, J. F. Eary, S. M. Beatty, W. B. Nelp, P. G. Abrams
Journal: Clinical Nuclear Medicine (1988)

Schroff, R. W.; Johnson, S. L.; Fritzberg, A. R.; Eary, J. F.; Beatty, S. M.; Nelp, W. B.; Abrams, P. G. Author Information
Platelet Glycoprotein IIb/IIIa Inhibition with Coronary Stenting for Acute Myocardial Infarction
Authors: Gilles Montalescot, Paul Barragan, Olivier Wittenberg, Patrick Ecollan, Simon Elhadad, Philippe Villain, Jean-Marc Boulenc, Marie-Claude Morice, Luc Maillard, Michel Pansiéri, Rémi Choussat, Philippe Pinton
Journal: New England Journal of Medicine (2001)

When administered in conjunction with primary coronary stenting for the treatment of acute myocardial infarction, a platelet glycoprotein IIb/IIIa inhibitor may provide additional clinical benefit, but data on this combination therapy are limited.
Abstract 2734: Tumor-associated antigen c-terminal binding protein-2 is overexpressed in epithelial ovarian tumors
Authors: Lisa M. Barroilhet, Junzheng Yang, William R. Welch, Ross S. Berkowitz, Shu-Wing Ng
Journal: Cancer Research (2010)

Abstract OBJECTIVES: Investigation of the expression pattern and functional roles of tumor antigen CtBP-2 in ovarian cancer. BACKGROUND: Tumor-associated antigens may have mechanistic function in cancer development and serum antibodies that target the tumor-associated antigens may have value in early detection. Antibodies to C-terminal binding protein 2 (CtBP-2), a component of the Wnt signaling pathway and a transcriptional corepressor via interaction with histone deacetylases (HDACs), were identified in patient serum using an innovative reverse capture antibody array method. We investigated the expression and function of CtBP-2 in human ovarian cancer tissue and ovarian cancer cell lines. METHODS: CtBP-2 expression was studied in 105 paraffin-embedded ovarian tumors by standard immunohistochemistry (IHC). ANOVA was used to compare the mean IHC staining scores (area stained x intensity) between healthy and tumor samples. Functional assays were performed with human ovarian cancer cell lines SKOV3 and MCAS that stably integrated a CtBP2-targeting short-hairpin RNA (shRNA) construct via a Lentivirus vector. Protein expression was examined by western blotting. Cell proliferation in culture was evaluated by cell counting. Cell adhesion assays were performed using a CytoMatrix Screen kit from Millipore. Cell migration assays were performed using a Boyden chamber-based cell migration assay. B-catenin activity was measured using a TOPFLASH luciferase reporter assay. Cellular sensitivity to trichostatin A, a HDAC inhibitor, was measured using MTT assay. RESULTS: 83% of ovarian epithelial tumors stained positive with a mean score of 4.77 (borderline tumors) and 5.49 (invasive tumors) and showed a significant difference (p-value 50% and showed reduced proliferation rates. The knock-down cell lines also showed 40-80% reduction in adhesion to extracellular matrix proteins collagen I and collagen IV, 50-70% reduction in migration, suppressed B-catenin activity and enhanced sensitivity to trichostatin A. CONCLUSIONS: CtBP-2 is overexpressed in ovarian epithelial tumors and cancer cell lines. Ovarian cancer cell lines with suppressed CtBP-2 expression show a reduction in proliferation rate, cell adhesion and cell migration. The phenotype may be related to suppressed B-catenin activity. The knockdown cell lines are also more sensitive to HDAC inhibitor trichostatin A, suggesting that the expression of CtBP-2 might modulate cellular response to HDAC inhibitor in the clinical setting. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2734.
Fatty Infiltration of Respiratory Muscles in the Pickwickian Syndrome
Authors: Edward J. Fadell, Anne Dunbar Richman, Will W. Ward, James Robert Hendon
Journal: New England Journal of Medicine (1962)

THE associated features of marked obesity, somnambulance, muscular twitching, cyanosis, secondary polycythemia and hypertrophy and failure of the right ventricle have been described1 2 3 4 5 and termed the Pickwickian syndrome.6 It has been observed that increase of abdominal girth by any means decreases expiratory reserve.1 It has also been proposed that obesity, through some unknown mechanism, leads to shallow respiration, and the combination of these two results in alveolar hypoventilation.7 8 9 10 The mechanism for decreased respiration has not been delineated. Burwell et al.6 suggested the possibility of fat infiltration of respiratory muscles, but there was seemingly no evidence to support this. Relatively few . . .
Redistribution
Authors: LUBAN MRHAC, SAAD ZAKKO, SAYED JAFFAR S. MOHAMMED, MOHAMMAD ALI KAYA
Journal: Clinical Nuclear Medicine (1997)

A 29-year-old man had severe pain of the right testicle. He had no history of trauma or sexual intercourse or any other sexual activity. Clinical examination suggested testicular torsion. Immediate radionuclide testicular study confirmed the clinical diagnosis. Manual detorsion was performed directly on the bed of the scintilation camera. Additional imaging performed 20 minutes later without any additional injection showed redistribution(i.e., restoration of the blood supply to the right testicle) and confirmed the success of detorsion.
A meeting which changed me: There is another way
Authors: P. Metayer
Journal: BMJ (1999)

I first encountered Jean-Claude in 1976 during a meeting organised by Le Comite de Defense contre l'Alcoolisme (national antialcoholism defence committee). The meeting comprised doctors, lawyers, social workers, and representatives from ex-alcoholics organisations, all concerned with the problem of alcohol. The end result had been rather disappointing and, as we left, Jean-Claude invited me to accompany him the following Wednesday to his Alcoholics Anonymous meeting. I had never heard of AA, and immediately accepted his offer.

I had just completed a study on sclerosing oesophageal varices and demonstrated that it had no effect on a patient's survival. After that I began to pay attention to the patients who had an alcohol problem. I noticed that this attention caused many of them to reduce or even stop the intake …
P19 Psychosical factors and the morbidity of severe asthma
Authors: A. Pooler, A. Caress
Journal: Thorax (2010)

<h3>Aim</h3> To examine if psychosocial variables; ie, personality, ways of coping, locus of control, levels of anxiety and depression and levels of social deprivation, could predict levels of lung function and numbers of exacerbations in severe asthma. <h3>Methods</h3> Participants all had severe asthma. Data on numbers of exacerbations was collected retrospectively over an 8-year period and levels of lung function assessed (FEV1% predicted and FEV1/FVC% predicted. Predictor variables measured using EPQ (personality), HADS (anxiety and depression), MHLOC (locus of control), WCC (ways of coping) and an individual social deprivation score. Standard multiple regression analysed the relationship between these predictor variables and the criterion variables of levels of lung function and numbers of exacerbations. <h3>Results</h3> N=102 from a severe asthma clinic in the midlands. High levels of depression and moderate levels of social deprivation showed significant relationships to high numbers of exacerbations (R<sup>2</sup>=0.458, Beta value=0.636, p=0.009 and R<sup>2</sup>=0.581. Beta value=0.280, p=0.009 respectively). No relationship was found between the predictor variables and level of lung function. <h3>Conclusion</h3> There are predictor variables which have a significant influence on the morbidity of severe asthma, which cannot be treated by conventional management techniques. Further work needs to be done to explore these variables and to develop management strategies for them in people with severe asthma.
Chronic Idiopathic Granulocytopenia
Authors: Carl E. Krill, Hugo Dunlap Smith, Alvin M. Mauer
Journal: New England Journal of Medicine (1964)

THERE are many reports describing patients with chronic granulocytopenia in whom no responsible disease could be demonstrated. Any classification of these patients other than a descriptive one would be difficult as yet because knowledge of the etiologies and mechanisms involved in most of these cases is scanty. The purpose of this paper is to describe a patient with chronic granulocytopenia who does not resemble previously reported cases and to present studies done in an attempt to define the underlying mechanism for the decreased blood granulocyte concentration.Case ReportA 9-year-old girl was referred to the Children's Hospital because of recurrent . . .
McCune-Albright Syndrome with Thyrotoxicosis
Authors: A K Singh, H J Dworkin, C Dickinson, P Sagar, E Peterson
Journal: Clinical Nuclear Medicine (2001)

SINGH, AJAY K. M.D.*; DWORKIN, HOWARD J. M.D.†; DICKINSON, CHRIS M.D.†; SAGAR, PALLAVI M.D.‡; PETERSON, ERIC* Author Information
FRI0258 Improvement of Cell Cholesterol Trafficking-Related Lipoprotein Functions in Rheumatoid Arthritis Patients Treated with Adalimumab
Authors: N. Ronda, D. Greco, M.P. Adorni, F. Zimetti, E. Favari, M.O. Borghi, I. Hollan, G. Hjeltnes, K. Mikkelsen, P.L. Meroni, F. Bernini
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> RA is associated with accelerated atherosclerosis. HDL in RA have reduced capacity to promote cell cholesterol efflux (CEC) while LDL have increased cholesterol loading capacity on macrophages (CLC). Inflammation and immune disturbances are among the mechanisms proposed. Anti-TNFa agents appear to reduce cardiovascular risk in RA, but their effects on serum lipid profile is variable. <h3>Objectives</h3> We studied modifications of lipoprotein function with respect to cell cholesterol trafficking after adalimumab therapy in RA. <h3>Methods</h3> Serum was drawn from 56 patients with RA, 34 treated with methotrexate (MTX), 22 starting with adalimumab in addition to ongoing MTX (MTX/ADA), before and after 6 weeks and 6 months of treatment. We measured: serum lipid profile; CLC with cholesterol measurement by fluorimetric technique; CEC with radioisotopic technique. <h3>Results</h3> HDL, LDL and total cholesterol serum levels increased in the MTX group after treatment, while HDL levels only increased in the MTX/ADA group. CLC significantly decreased after treatment in the MTX/ADA group only (mean ± SE, 7.16±0.28 vs 7.92±0.48 mg cholesterol/mg protein, p&lt;0.05). In MTX group ATP-binding cassette G1 (ABCG1) and Scavenger receptor-BI (SR-BI)-mediated CEC increased after treatment; in MTX/ADA group SR-BI-mediated CEC increased. No modifications in ATP-binding cassette A1-mediated CEC occurred in either MTX or MTX/ADA group. <h3>Conclusions</h3> Adalimumab addition to MTX treatment results in decreased cell cholesterol loading serum capacity and slight improvement in HDL promotion of cell cholesterol efflux, both potentially inhibiting foam cell formation. These effects may be especially relevant in RA patients with aggressive disease needing anti-TNFa, particularly prone to accelerated atherosclerosis. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2441
Abstract 2694: SRC-1 promotes tumor angiogenesis through up-regulation of HIF1α-mediated VEGFa expression.
Authors: Li Qin, Yixiang Xu, Zhen Feng, Yelin Wu, Yan Xu, Lan Liao, Jianming Xu
Journal: Cancer Research (2013)

Abstract Steroid receptor coactivator 1 (SRC-1) belongs to the p160 coactivator family which also contains SRC-2 (TIF2) and SRC-3 (AIB1/pCIP/ACTR/RAC3). These coactivators interact with nuclear receptors and other transcription factors to up-regulate gene expression. Accumulated evidence shows that SRC-1 exerts its promotive role in breast cancer progression and metastasis by up-regulating transcription of multiple genes important for tumor cell epithelial-mesenchymal transition (EMT), migration, invasion and endocrine therapy resistance. However, its role in tumor angiogenesis has not been examined. In our recent studies using SRC-1 KO/PyMT and WT/PyMT mammary tumor cell lines established in our lab, we found that injection of SRC-1 KO/PyMT cells to matrigel plug formed under the back skin in SCID mice induced less blood vessel formation compared with that of WT/PyMT tumor cells. Accordingly, injection of human breast cancer MDA-MB-231 cells with stable knockdown of SRC-1 by shRNA to the matrigel plug also induced less neovascularization. Meanwhile, VEGFa mRNA level is significantly reduced in mammary tumors from SRC-1 KO/PyMT transgenic mice. On the contrary, in SRC-1-overexpressed mammary tumors from MMTV/TVA/PyMT mice, the expression of VEGFa was dramatically increased. In agreement with these findings, in vitro studies revealed that VEGFa mRNA levels are much lower in two of the SRC-1 KO/PyMT tumor cell lines compared with WT/PyMT cell lines. Knockdown of SRC-1 in WT/PyMT cells and human MDA-MB-231 cells reduced VEGFa levels, while adenovirus-mediated re-expression of SRC-1 in SRC-1 KO/PyMT cells significantly potentiated VEGFa expression. Furthermore, promoter analyze revealed that SRC-1 could interact with HIF-1α and AP-1 to potentiate the VEGFa promoter activity. We also found that both SRC-1 and HIF-1α are associated with a VEGFa promoter region by ChIP assays. These results indicate that SRC-1 can promote breast cancer progression and metastasis through enhancing tumor angiogenesis. Targeting SRC-1 may be a feasible strategy for inhibiting breast tumor angiogenesis and metastasis. Citation Format: Li Qin, Yixiang Xu, Zhen Feng, Yelin Wu, Yan Xu, Lan Liao, Jianming Xu. SRC-1 promotes tumor angiogenesis through up-regulation of HIF1α-mediated VEGFa expression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2694. doi:10.1158/1538-7445.AM2013-2694 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
In vivo and in vitro effects of cytokines and the hemoregulatory peptide dimer (pEEDCK)2 (pyroGlu-Glu-Asp-Cys-Lys)2 on Gα16-positive hematopoiesis
Authors: M Pfeilstöcker, H Karlic, J Paukovits, G Anzenberger, N Louda, J Salamon, H Mühlberger, H Strobl, E Pittermann, R Heinz
Journal: Leukemia (1999)
Recurrent Ectopic Adrenocorticotropic Hormone Producing Thymic Carcinoid Detected With Octreotide Imaging
Authors: F Silva, J Vázquez-Sellés, F Aguilö, G Vázquez, C Flores
Journal: Clinical Nuclear Medicine (1999)

Primary thymic carcinoids are rare tumors in which the tumor cells retain functional somatostatin receptors. In-111-labeled octreotide imaging has been used to diagnose abdominal carcinoids with a sensitivity rate of approximately 87%. The authors describe a case of a recurrent, ectopic cortisol-releasing hormone that produced thymic carcinoid localized as a focal area of increased activity in the upper mediastinum when planar and tomographic octreotide scintigraphy was used. Chest CT and MRI failed to localize the tumor. This may be the first reported case of In-111-labeled octreotide used to identify Cushing's syndrome caused by a cortisol-releasing hormone that produced thymic carcinoid.
Paget's Disease of the Metacarpal
Authors: MICHAEL S. STECKER, PHILIP A. BARDFELD
Journal: Clinical Nuclear Medicine (1996)

Involvement of the hands in Paget's disease (osteitis deformans) is infrequent. The radiographic findings have been detailed elsewhere, but the findings using Tc-99m MDP bone scanning have not been well described. A Tc-99m MDP bone scan was performed on a 77-year-old woman with known Paget's disease of the skull and vertebrae. Images obtained of the hands and forearms demonstrated diffuse, homogeneous, increased radionuclide uptake in the entire left first metacarpal. Roentgenograms were obtained for correlation. No other hand bones were affected.
Relation between reduced coronary vasodilator capacity and systemic small artery hypertrophy in hypertensive patients with chest pai
Authors: Carlo Palombo, D. Rizzoni, E. Porteri, M. Kozàkovà, L. M. Muiesan, G. La Canna, D. Guelfi, C. Morizzo, F. Vittone, E. Agabiti Rosei
Journal: Journal of the American College of Cardiology (2001)
Abstract 2090: Investigating peroxiredoxin expression, activity, and potential downstream signaling in cancerous MCF7 and normal MCF10A breast epithelial cells
Authors: Katie Sullivan, Kevin Goncalves, Maryam Sumra, Shelley A. Phelan
Journal: Cancer Research (2011)

Abstract Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from oxidative stress. They have been implicated in cell signaling, proliferation and apoptosis, and studies have found elevated levels in many types of cancer, suggesting a protective role for these proteins in cancer cells. We previously showed that Prdx1 is overexpressed in the MCF7 breast cancer line as compared to the normal MCF10A line, and that suppression of Prdx1 and/or Prdx6 increases susceptibility to oxidative stress-induced apoptosis, with a more profound effect in MCF10A cells. In the present study, we sought to investigate other differences in peroxiredoxin expression and activity between these lines, as well as potential downstream targets. We found that mRNA levels of Prdxs1-5 were significantly elevated in MCF7 cells, while comparable levels of Prdx6 mRNA were found. A Prdx6 antibody, however, detects two bands by western blot: an upper 30-32 kDa species expressed at equal levels in both lines, and a 24-26 kDa species significantly overexpressed in MCF7 cells. An antibody specific for oxidized Prdx6 detected both products, demonstrating elevated levels in the cancer cells. Interestingly, the two species were differentially affected by siRNA-mediated Prdx1 and/or Prdx6 suppression. We further examined potential downstream targets of peroxiredoxin-regulated signaling. The two lines showed relatively comparable levels of p38, JNK1, ERK2, and c-Abl1b mRNA. In contrast, ERK1 mRNA levels were higher in MCF7 cells, while c-Abl1a was expressed only in the normal line. Peroxiredoxin suppression by siRNA transfection had no significant effect on p38, ERK1, or ERK2 in either cell type, but did lead to a decrease in c-Abl and JNK1 expression differentially in the two lines. Together, these data suggest different roles for Prdx1 and Prdx6 in normal vs. cancerous breast epithelial cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2090. doi:10.1158/1538-7445.AM2011-2090