tbuckley/cabot-search huggingface dataset:
AB1094 Leucine-Rich-Alpha Glycoprotein-1 (LRG1) and Lupus Nephritis
Authors: T. Ohkawara, H. Lee, S. Serada, Y. Hosono, M. Fujimoto, T. Mimori, T. Naka
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic Lupus erythematousis (SLE), which pathology is not well understood, is an autoimmune disorder with a range of presentations. Among these, lupus nephritis (LN) is a particularly severe feature of SLE that predicts a poor outcome.<sup>1</sup> Classification of lupus nephritis is determined by renal biopsy, whitch is a very invasive diagnostic method. <h3>Objectives</h3> To develop a new noninvasive diagnostic method to classify lupus nephritis, we focused on urinary level of Leucine-rich alpha-2-glycoprotein-1 (LRG1), which is a novel inflammatory maker and expressed at inflammation in the inflammatory local site.<sup>2</sup> <h3>Methods</h3> We divided SLE patients into four groups (group 1: LN class 1 and 2 (ISN/RPS), group 2: LN class 3 and 4, group 3: LN class 5 and group 4: unknown), and compared serum and urinary level of LRG1 between groups by ELISA. Next, using a spontaneous animal lupus nephritis model NZB/NZW F1 mouse, we evaluated the expression of LRG1 in kidney by real-time PCR, Immunohistochemistry (IHC), in situ hybridization, and measured serum and urinary level of LRG1 by ELISA. <h3>Results</h3> In SLE patients, group 2 was the highest in the urinary level of LRG1 and, group 1 and group 3 was slightly higher than healthy control. In NZB/W F1 mouse, urinary LRG1 was detected at 5 or 6months old, and gradually elevated. In 8 months old mouse exhibiting LN class 2–4, expression of LRG1 was observed in renal tubular epithelial cells in IHC and in situ hybridization, in realtime PCR, we comfirmed that LRG1 expression was elevated in kidney. <h3>Conclusions</h3> Measuring urinary level of LRG1 can become a new maker of LN. LRG1 may be involved in the pathogenesis of LN. <h3>References</h3> Golbus J, McCune WJ. Lupus nephritis. Classification, prognosis, immunopathogenesis, and treatment. Rheumatic diseases clinics of North America 1994;20(1):213-42. Serada S, Fujimoto M, Terabe F, et al. Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis. Inflammatory bowel diseases 2012;18(11):2169-79. <h3>Disclosure of Interest</h3> None declared
Unknown disease in South Africa identified as arenavirus infection
Authors: H Zeller, K Leitmeyer, C Varela Santos, D Coulombier
Journal: Eurosurveillance (2008)

On 12 September 2008, a tourist guide organising safari trips, residing in Lusaka, Zambia, was evacuated in a critical condition to Johannesburg, South Africa. She was admitted to a clinic where she died on 14 September about 10 days after the onset of symptoms. The symptoms included a prodromal phase with fever, myalgia, vomiting, diarrhoea, followed by rash, liver dysfunction and convulsions [1]. Cerebral oedema was detected on scan examination. No laboratory specimen was available for investigation.
Organic mental disorders caused by HIV: update on early diagnosis and treatment
Authors: S W Perry
Journal: American Journal of Psychiatry (1990)

HIV directly affects the CNS, primarily causing subcortical neuropathology. Dementia as the initial presentation is rare, but organic mental changes that mimic many functional disorders can occur during the course of infection. The mental status examination is not adequately sensitive to detect noncognitive dysfunction, and subjective complaints, neurological signs, reduced T4 lymphocytes, CSF abnormalities, diffuse slowing on ECG, mild cerebral atrophy on brain CT, and nonspecific hyperdensities on brain magnetic resonance imaging do not correlate reliably with early and subtle HIV-induced neuropsychological impairment. Zidovudine (AZT) can delay or reverse mental deficits, and psychostimulants can reduce apathetic withdrawal, but high-potency neuroleptics can cause neuroleptic malignant syndrome.
Mining gene expression data
Authors: Mark Patterson
Journal: Nature Reviews Genetics (2000)

HomophilaDespite Homophila's spooky homepage, human geneticists curious to know what their disease gene does in Drosophila have nothing to fear.Ethan Bier and his colleagues at UCSD have compared the gene sequences entered in the Online Mendelian Inheritance in Man (OMIM) database to the genes, EST or genomic sequences in Flybase, the Drosophila sequence database.There is a story behind the creation of this web site.After finding that 74.5% of 909 distinct human disease genes have close homologues in fruitflies, the researchers scribbled the gene names and their corresponding syndromes on cards and handed them to a pathologist, who dutifully placed them into piles according to the nature of the disorder.This evolved into Homophila, a site where human disease genes and their fly homologues can be searched according to keyword, human disease name, gene name or OMIM entry number.For instance, typing in 'hypertension' leads to a results table showing, on the left, a description of the human disorder, the human gene symbol (for example, for the angiotensin II receptor) and related online references; on the right, the Drosophila protein sequence matches.In case you're daunted by the prospect of trundling through fruitfly data, a link from the fly gene of interest to GadFly (Genome Annotation Database of Drosophila) leads you to all that is known about the gene.There's more to come, as the site curators promise a facility to match disease phenotypes that are common to humans and flies.As molecular signalling pathways are more completely described in flies compared with humans, human disease genes could be cloned on the basis of fly mutant phenotypes that are typical of a particular pathway.The site is updated monthly, so keep a lookout.
Histopathologic Study of the Mode of Inhibition of Cellular Proliferation by Urethane: Effect of Urethane on Wound Healing&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: C C LUSHBAUGH, J W GREEN, J B STORER
Journal: JNCI Journal of the National Cancer Institute (1948)
Involvement of proprotein convertase PCSK7 in the regulation of systemic iron homeostasis
Authors: Johann Guillemot, Nabil G. Seidah
Journal: Hepatology (2013)

We very much appreciate the kind comments made by Schwienbacher et al. regarding our article on the implication of PC7 as the sheddase of human transferrin receptor 1 (TfR1).1 We read with great interest their observation of the lack of involvement of PC7 in hemojuvelin (HJV) shedding. Herein, we tested the hypothesis that PC7 could also regulate iron homeostasis by way of shedding of the human hemochromatosis protein (HFE). HFE is a membrane protein that binds the two receptors TfR1 and TfR2. HFE and holotransferrin compete for binding to TfR1. When the levels of holotransferrin are high, HFE is displaced from TfR1 and binds TfR2 to signal for hepcidin production.2 A recent study indicated the existence of a soluble HFE in human serum that binds shed TfR1.3 Analysis of the sequence of HFE revealed single basic amino acid cleavage sites that could potentially be recognized by a proprotein convertase. The most probable ones are in the sequence ….RAAEP RAWPTKLEWERHKIRARQNRAYLERDCPAQ190…. Accordingly, in human hepatoma HuH7 cells we coexpressed PC7 or Furin with HFE carrying a Protein C-tag at its N-terminus and a V5-tag at its C-terminus (Fig. 1A). The data revealed that overexpression of PC7 or Furin did not result in enhanced HFE shedding over background (Fig. 1B). This is likely due to a high helical secondary structure around the potential basic amino acid cleavage sites (Fig. 1A). Moreover, in HuH7 cells coexpression of TfR1 with HFE in the absence or presence of PC7 showed that HFE did not affect the ability of PC7 to shed TfR1 (Fig. 1C). We conclude that, so far, PC7 regulates iron homeostasis only through TfR1 shedding.1 The available data show that Furin, but not PC7, can activate hepcidin and shed HJV, and that neither Furin nor PC7 can cleave HFE. JOHANN GUILLEMOT, Ph.D.NABIL G. SEIDAH, Ph.D. Laboratory of Biochemical NeuroendocrinologyClinical Research Institute of Montreal (IRCM)Affiliated with the University of Montreal Montreal Quebec, Canada
Defining intracellular signaling targets in soft tissue sarcoma (STS) using immunohistochemical staining (IHC)
Authors: D. A. Forman, M. Scarlato, R. E. Brown, C. Amadio, E. L. Friedman, S. Berman, G. Robertson, P. Mosca, S. G. Nair
Journal: Journal of Clinical Oncology (2006)

9577 Background: Pathologic events pertaining to the intracellular cell signaling pathway are now being recognized to be directly or indirectly responsible for oncogenic transformation in a variety of malignancies. Many drugs are now available which can block key steps of these signaling pathways. We sought to use IHC stains of previously stored sarcoma specimens to determine if expression of potential molecular targets (mTOR, p 70 S6 Kinase, ERK1/2, NF Kappa B) is present. Methods: Using tumor registry data, our three most common adult STS histopathologic subtypes were identified, and paraffin embedded tissue blocks representing these histologies were retrieved. Each block was reviewed for tissue adequacy. The blocks were cut and then stained with the aforementioned phosphorylated IHC stains (Cell Signal Technologies). Slides were graded on intensity of stain uptake (0–3+) and percentage of cells staining. A particular IHC stain was considered positive if 10% or more cells were stained 1+ or greater in intensity. Results: Seventeen Malignant Fibrous Histiocytomas (MFH), 20 Leiomyosarcomas (LMS) and 7 Liposarcomas were stained for the presence of p-mTOR, p-p70S6 Kinase, p ERK1/2, and p-NF Kappa B. Data for NF Kappa B will be presented at the meeting. The results are summarized in the table below. Conclusions: Pathways involving ERK appear to be active in more frequently diagnosed Sarcomas. Slightly more than half of the MFHs we studied expressed phosphorylated ERK1/2. Further exploration of this pathway, as well as mTOR, as potential targets of therapeutic intervention is indicated in STS. [Table: see text] No significant financial relationships to disclose.
Leishmaniasis presenting as small isolated mediastinal lymphadenopathy diagnosed by endoscopic ultrasound-guided fine-needle aspiration
Authors: Narendra Choudhary, Sushila Kataria, Mridula Guleria, Rajesh Puri
Journal: Endoscopy (2015)

A 41-year-old man from Afghanistan presented with pyrexia of unknown origin and weight loss for 2 months. His work-up revealed anemia (hemoglobin 7.7 g/dL) and leukopenia (2990 cells/μL), and he was positive for human immunodeficiency virus type 1 (HIV 1).
Gray platelet syndrome can mimic autoimmune lymphoproliferative syndrome
Authors: Anne Rensing-Ehl, Ulrich Pannicke, Stefanie-Yvonne Zimmermann, Myriam Ricarda Lorenz, Benedicte Neven, Ilka Fuchs, Ulrich Salzer, Carsten Speckmann, Anne Strauss, Eberhard Maaβ, Benedicte Collet, Anselm Enders, Remi Favier, Marie Christine Alessi, Frederic Rieux-Laucat, Barbara Zieger, Klaus Schwarz, Stephan Ehl
Journal: Blood (2015)
THU0143 Heterogeneity of Joint Deformity in Rheumatoid Arthritis Revealed by Cluster Analysis
Authors: E.T. Koh, L.Z. Liu, J.W.L. Tan, W.Q. See, K.P. Leong
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The application of statistical clustering methods to various clinical datasets has revealed unexpected patterns of disease that may have practical implications. There are advantages to categorising patients with rheumatoid arthritis (RA) into distinct subsets for treatment and prognostication. <h3>Objectives</h3> To examine the cluster pattern of joint deformity of an inception cohort of RA patients. <h3>Methods</h3> All patients fulfilled the 1987 ACR criteria for RA, had ≤2 years disease duration at recruitment and were followed up from enrolment till 2014. Correlation of joint deformity symptoms at last study visit among the eight joints were analysed using eigen vectors from principal component analysis. K-means clustering analysis was applied to classify the RA patient subgroups based on distribution of joint deformity involvement. Joint deformity pattern was analysed at the last visit and correlated with socioeconomic, extra-articular features (EAF), DAS28 and HAQ scores, rheumatoid factor (RF), anti-citrullinated peptide antibody (ACPA) status and treatment. <h3>Results</h3> The mean age of the RA cohort was 50.4 years, 75.5% were Chinese and mean follow-up period was 88.4 months. Correlation analysis showed that the joint deformity involvement could be classified into three categories: proximal interphalangeal/metacarpophalangeal joint (PIP/MCP), shoulder/elbow/ankle (S/E/A) and wrist/knee/metatasophalangeal (W/K/MTP). Cluster analysis showed four patterns of joint deformity: mild involvement of PIP/MCP joints (group I), dominant involvement of S/E/A and W/K/MTP (group II), W/K/MTP involvement (group III) and dominant PIP/MCP/S/E/A/W/K/MTP involvement (group IV). There was no significant difference in mean age, disease duration, work status, occupation, smoking status, prevalence of RF and ACPA, DAS28 and HAQ scores among the four groups. Group IV patients had a significantly longer symptom duration prior to diagnosis, received higher number of non-biologic DMARDs and were more likely to have radiographic erosions (p&lt;0.05). Unlike other joints, wrist deformity was significantly correlated with prior wrist tenderness or swelling (34.5% of patients). <h3>Conclusions</h3> Cluster analysis showed four subgroups of RA patients based on pattern of joint deformity. The presence of wrist synovitis at baseline may predict wrist deformity. Factors other than socioeconomic, RF, ACPA need to be explored to explain the clustering of joint deformity in our inception cohort. <h3>Acknowledgements</h3> We thank Ms Safiyya Mohamed Ali for her kind assistance. <h3>Disclosure of Interest</h3> None declared
P14 Mycophenolate mofetil in patients with autoimmune hepatitis intolerant to azathioprine
Authors: D Jothimani, U Warshow, A Barnardo, M Cramp, J Mitchell, T Cross
Journal: Gut (2010)

Introduction  Autoimmune hepatitis (AIH) is an immune mediated necroinflammatory condition of the liver. The majority of patients respond to the standard treatment combination of prednisolone and azathioprine. Twenty percent of patients either don9t respond, or are intolerant to azathioprine. Several case series supports the use of mycophenolate mofetil (MMF) as a second line agent in refractory AIH. Its role is unclear in patients intolerant to azathioprine.  Aim  To evaluate the efficacy and tolerability of MMF for the management of AIH.  Method  A retrospective case note review from January 2000 to March 2010 in patients diagnosed with AIH (immune profile and liver biopsy). Patients on MMF were identified and evaluated. Treatment response to MMF was defined as a biochemical remission within 4 weeks of treatment commencement and treatment failure as either a non-response or relapse while on standard therapy.  Results  117 patients with autoimmune hepatitis were identified. 20/117 (17%) received MMF. The median age was 56 years (18–79 years) with male/female, 1:7. Three patients had overlap syndrome with autoimmune cholangitis, PSC and PBC, and six had cirrhosis. All patients were commenced on prednisolone for induction at a median dose of 30 mg (7.5–40 mg) and azathioprine within 3 months for remission. Azathioprine was discontinued due to intolerance following its adverse events, such as leucopenia, nausea and diarrhoea in 18 patients within 4 months (0–24 months). Two patients were true non-responders to azathioprine. All these patients were commenced on MMF at a median dose of 1 g twice daily in addition to low dose maintenance prednisolone. At a median follow-up of 47 months (5–83 months), MMF was well tolerated and 14/19 patients (one lost to follow-up) remained in remission including five patients with cirrhosis. Intolerance to MMF was seen in three patients (skin rash, hair loss) and poor response in two patients.  Conclusion  Our case series supports the use of MMF as a second-line agent in AIH patients intolerant to azathioprine. It was well tolerated in patients including those with cirrhosis.
AB0489 Leucine-Rich Alpha-2 Glycoprotein (LRG) as a Potential Disease Activity Marker During IL-6 Blockade in Autoimmune Arthritis
Authors: Y. Takahashi, M. Fujimoto, S. Serada, A. Ogata, T. Nanki, K. Hattori, T. Takeuchi, T. Naka
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> C-reactive protein (CRP) is frequently used to evaluate inflammation in patients with rheumatoid arthritis (RA). However, CRP is normalized when IL-6 function is potently suppressed by anti-cytokine biologics such as tocilizumab. Therefore, there is growing need for a new biomarker that can detect RA disease activity during this therapy. By proteomic screening of sera from patients with RA, we previously identified serum leucine-rich alpha-2 glycoprotein (LRG) as a potential biomarker that reflects disease activity in RA better than CRP. <h3>Objectives</h3> The object of this study is to investigate the clinical significance of LRG as a biomarker of RA disease activity during anti-IL6 biologic therapy. <h3>Methods</h3> As a preclinical testing, cynpmolgus monkeys with collagen induced arthritis (CIA) were treated with anti-IL-6 receptor antibody (anti-IL-6-R mAb) and joint sewelling and rigidity were scored for clinical assessment of arthritis throughout the experiment. At the time of sacrifice, blood samples were collected and serum LRG and CRP levels were evaluated. <h3>Results</h3> In CIA monkeys with anti-IL-6R mAb treatment, plasma LRG levels correlated better with disease activity than plasma CRP levels, presumably due to the fact that LRG levels were elevated in some animals with negative CRP in spite of high arthritis scores. Furthermore, among tocilizumab-treated patients for 6months with normalized CRP levels, serum LRG levels were significantly higher in patients with active RA (defined by CDAI&gt;2.8) than those with RA in remission (CDAI≤2.8). <h3>Conclusions</h3> Our study indicates that LRG is more useful biomarker for discriminating active diseases in RA, even when CRP levels are reduced or normalized under IL-6 suppression. <h3>References</h3> Navarro-Millán I, et al. Systematic Review of Tocilizumab for Rheumatoid Arthritis: A New Biologic Agent Targeting the Interleukin-6 Receptor Receptor Clin Ther 2012; 788-802 <h3>Disclosure of Interest</h3> None declared
Joint Decision Making and Reduced Need for Compulsory Psychiatric Admission
Authors: Graham Thornicroft, Claire Henderson
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Primary Cold Agglutinin Associated Lymphoproliferative Disease: A B-Cell Lymphoma Of The Bone Marrow Distinct From Lymphoplasmacytic Lymphoma
Authors: Ulla Randen, Gunhild Trøen, Anne Maria Tierens, Chloe Steen, Warsame Abdirashid, Beiske Klaus, Tjønnfjord Geir, Berentsen Sigbjørn, Jan Delabie
Journal: Blood (2013)
Hemospray rescue treatment of gastroenteric anastomotic bleeding
Authors: Antonino Granata, Dario Ligresti, Gabriele Curcio, Luca Barresi, Ilaria Tarantino, Rosalba Orlando, Mario Traina
Journal: Endoscopy (2015)

A 52-year-old man with chronic pancreatitis and pancreatic exocrine insufficiency developed a duodenal bulb stenosis that caused postprandial vomiting. He underwent a gastroenteric anastomosis to restore the intestinal flow. He was readmitted 30 days after discharge with hematemesis, hypovolemic shock, and severe anemia (hemoglobin 6.6 g/dL). He was resuscitated, and an emergency gastroscopy was carried out, which showed an oozing bleeding point likely secondary to a post-surgical vascular ectasia in the border of the gastroenteric anastomosis ([Fig. 1 a, b]).
National pneumococcal vaccination programmes for children in Europe, 2001-2007: update from Turkey
Authors: U Ozdemirer
Journal: Eurosurveillance (2009)

Preview this article: National pneumococcal vaccination programmes for children in Europe, 2001-2007: update from Turkey, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/14/18/art19202-en-1.gif
6. Reflections on the emergence of new thematic research: Development of electrospun nanostructured DNA delivery scaffolds
Authors: Nicholas A. Peppas, Ruth Duncan, Gary E. Wnek, Allan S. Hoffman, Guang Hui Gao, Sung Wan Kim, Doo Sung Lee, Michael Hadjiargyrou, Elka Touitou, Denize Ainbinder, Russell Mumper, Alain Rolland, Takuro Niidome, Vinod Labhasetwar, Shi Liu, Guangyuan Zhou, Yubin Huang, Zhigang Xie, Xiabin Jing, Noemi Csaba
Journal: Journal of Controlled Release (2014)
Mucoepidermoid Tumors of Salivary Glands
Authors: V V PANIKAROVSKII, T E GOSH
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Influence of Continued and Intermittent Painting with Croton Oil on Skin Tumorigenesis in Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Michael Klein
Journal: JNCI Journal of the National Cancer Institute (1953)

Influence of Continued and Intermittent Painting with Croton Oil on Skin Tumorigenesis in Mice Get access Michael Klein Michael Klein Cancer Research Laboratory, University of Florida, Gainesville, Fla. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 1, August 1953, Pages 83–91, https://doi.org/10.1093/jnci/14.1.83 Published: 01 August 1953 Article history Received: 09 February 1953 Published: 01 August 1953