tbuckley/cabot-search huggingface dataset:
Thrombopoietin-Receptor Agonists for Immune Thrombocytopenia
Authors: A.J. Gerard Jansen, Reinout M. Swart, Peter A.W. te Boekhorst
Journal: New England Journal of Medicine (2011)

To the Editor: In response to the review by Imbach and Crowther (Aug. 25 issue)1 of thrombopoietin-receptor agonists for primary immune thrombocytopenia: we would like to draw attention to the fact...
Physical Exertion as a Trigger of Acute Myocardial Infarction
Authors: Stefan N. Willich, Michael Lewis, Hannelore Lowel, Hans-Richard Arntz, Frauke Schubert, Rolf Schroder
Journal: New England Journal of Medicine (1993)

It is controversial whether the onset of myocardial infarction occurs randomly or is precipitated by identifiable stimuli. Previous studies have suggested a higher risk of cardiac events in association with exertion.
Racial Differences in the Treatment of Early-Stage Lung Cancer
Authors: Peter B. Bach, Laura D. Cramer, Joan L. Warren, Colin B. Begg
Journal: New England Journal of Medicine (1999)

If discovered at an early stage, non–small-cell lung cancer is potentially curable by surgical resection. However, two disparities have been noted between black patients and white patients with this disease. Blacks are less likely to receive surgical treatment than whites, and they are likely to die sooner than whites. We undertook a population-based study to estimate the disparity in the rates of surgical treatment and to evaluate the extent to which this disparity is associated with differences in overall survival.
Complications hémorragiques du dépistage organisé du cancer colorectal par Hemoccult®: une série de plus de 10000 coloscopies
Authors: B Denis, I Gendre, H Uettwiller, P Perrin
Journal: Endoscopy (2011)

Introduction: Le but de ce travail était d'évaluer les complications hémorragiques des coloscopies du programme national de dépistage organisé (DO) du cancer colorectal (CCR) par Hemoccult.
Effect of PTPN22 Gene Variant R620W on Type I Interferon Production Stimulated by Different Toll‐like Receptor 7 Agonists: Comment on the Article by Wang et al
Authors: Olof Berggren, Lars Rönnblom, Maija‐Leena Eloranta
Journal: Arthritis & Rheumatology (2016)

The effect of PTPN22 Gene Variant R620W on the Type I Interferon Production Stimulated by Different TLR7 Agonists : Comment on Article by Wang et al (pages 2403-2414)
Abstract 1749: Cell cycle requirements shape ovarian cancer progression.
Authors: Barbie Taylor-Harding, Hasmik Agadjanian, Sandra Orsulic, Christine Walsh, Beth Y. Karlan, Wolf-Ruprecht Wiedemeyer
Journal: Cancer Research (2013)

Abstract Acquired resistance to chemotherapeutic drugs and subsequent recurrence of drug-resistant cancer are serious challenges associated with epithelial ovarian cancer. Most high-grade tumors initially respond well to the combination of platinum and taxane-based agents but recur as platinum-resistant disease, which is incurable. In addition, a subset of primary tumors, including CCNE1-amplified tumors, are inherently less susceptible to standard chemotherapy. Studies by The Cancer Genome Atlas have revealed that CCNE1 (cyclin E) amplification is mutually exclusive with mutations in BRCA1 and BRCA2, which render ovarian cancer cells sensitive to DNA-damaging agents and PARP inhibitors, as a result of synthetic lethality. In order to develop a similar therapeutic concept for CCNE1-amplified cancers, we have studied responses and resistance mechanisms of human ovarian cancer cells to several pharmacological inhibitors of cyclin-dependent kinases (CDK). Functional and biochemical studies have established cyclin E as an activator of CDK, which phosphorylate the RB tumor suppressor. However, despite the functional importance of the RB pathway in cancer, CDK inhibitors (CDKi) have yet to make a significant impact on the management of solid tumors. Here, we describe oncogenic pathways that are activated in CDKi-resistant cells and play critical roles in tumor progression and drug resistance. Targeting individual CDK or subsets of multiple CDK in vitro and in vivo, we found that cyclin E dependence was the main driving force that shaped tumor progression in different model systems of CCNE1-amplified and recurrent ovarian cancer. We identified robust and specific compensatory mechanisms that sustain cyclin E-associated activity in CDKi-resistant cells via activation of oncogenic signaling upstream of the cyclin E-RB-E2F axis. Specific targeting of cooperating oncogenes increased CDKi efficacy and prevented the outgrowth of CDKi-resistant cancer cells. Collectively, our results suggest that CDKi can be highly effective elements of combination therapy. Citation Format: Barbie Taylor-Harding, Hasmik Agadjanian, Sandra Orsulic, Christine Walsh, Beth Y. Karlan, Wolf-Ruprecht Wiedemeyer. Cell cycle requirements shape ovarian cancer progression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1749. doi:10.1158/1538-7445.AM2013-1749
MORE IMPAIRED DIASTOLIC FUNCTION OF LIGHT CHAIN AMYLOIDOSIS CONTRIBUTE TO POOR PROGNOSIS COMPARED WITH TRANSTHYRETIN AMYLOIDOSIS: RESULT FROM LONGITUDINAL STUDY OF BIOPSY-PROVEN CARDIAC AMYLOIDOSIS
Authors: Mari Sakamoto, Akira Funada, Makoto Amaki, Takahiro Ohara, Takuya Hasegawa, Yasuo Sugano, Hideaki Kanzaki, Masafumi Kitakaze, Toshihisa Anzai
Journal: Journal of the American College of Cardiology (2015)
Why You Should Care about Screening Flexible Sigmoidoscopy
Authors: John M. Inadomi
Journal: New England Journal of Medicine (2012)

The clinical outcomes of colorectal-cancer screening in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, now presented by Schoen et al. in the Journal, 1 show that the programmatic use of flexible sigmoidoscopy reduced colorectal-cancer incidence by 21%, with a benefit observed in both the proximal and the distal colon. Although overall colorectal-cancer mortality was reduced by 26%, the benefit of screening flexible sigmoidoscopy was limited to the distal colon, for which there was a 50% reduction in mortality. These findings confirm the results of a large trial in the United Kingdom that showed the efficacy of flexible sigmoidoscopy . . .
Charging patients fees is bad medicine
Authors: Des Spence
Journal: BMJ (2013)

A poll of general practitioners, recently splashed all over the newspapers, had most supporting charging patients up to £25 (€29; $39) a visit.1 The rationale runs like this. When something is free it isn’t valued. So patients don’t value doctors or our advice. Fees would stop the so called time wasters who abuse the system, reduce workload, free up time for deserving sick people, and, in the process, raise much needed income. A win-win, backslapping, punch-the-air and kiss-the-person-beside-you sort of good idea, isn’t it?⇑

Not really. Collecting money is expensive. In …
PMO-136 Defective inhibitory molecules expression may contribute to breakdown of tolerance characteristic of autoimmune liver disease
Authors: R Liberal, C Grant, C Grant, G Mieli-Vergani, D Vergani, M Longhi
Journal: Gut (2012)

<h3>Introduction</h3> Autoimmune hepatitis (AIH) is a severe hepatopathy often progressing to end-stage liver disease. Evidence implicates the involvement of both CD4 and CD8 T cell responses in its pathogenesis. There are a number of different inhibitory molecules expressed by T cells that can attenuate T cell receptor signalling. These include cytotoxic T lymphocyte antigen-4 (CTLA-4), programmed death-1 (PD-1), and the recently described T cell immunoglobulin and mucin domain-3 (Tim-3). Whether a disturbed expression of these inhibitory molecules can result in an increased susceptibility to autoimmune liver disease is unknown. <h3>Aims</h3> to evaluate the expression of CTLA-4, PD-1, and Tim-3 by CD4 and CD8 T cells in patients with autoimmune hepatitis. <h3>Methods</h3> 12 ANA/SMA+ AIH patients (6 females, median age: 14 years) and 6 healthy subjects (HS, four females, median age: 26.4 years) were studied. Phenotype of CD4 and CD8 T cells was determined by flow cytometry using monoclonal antibodies against CD4, CD8, PD-1 and Tim-3. Expression of CTLA-4 was determined by intracellular staining. <h3>Results</h3> The frequency of Tim-3<sup>pos</sup> and PD-1<sup>pos</sup> cells within CD4 and CD8 T cells was lower in AIH (CD4<sup>pos</sup>Tim-3<sup>pos</sup>: 1.6±0.3; CD4<sup>pos</sup>PD-1<sup>pos</sup>: 4.8±0.5; CD8<sup>pos</sup>Tim-3<sup>pos</sup>: 9.6±1.6; CD8<sup>pos</sup>PD-1<sup>pos</sup>: 6.7±0.7) than in HS (CD4<sup>pos</sup>Tim-3<sup>pos</sup>: 6.2±0.8, PposPD-1<sup>pos</sup>: 8.1±1.9, P=0.04; CD8<sup>pos</sup>Tim-3<sup>pos</sup>: 15.8±1.8, P=0.04; CD8<sup>pos</sup>PD-1<sup>pos</sup>: 12.6±1.4 6.7±0.7, Ppos cells between the two groups of subjects. While in health dually Tim-3 and PD-1 positive populations are recognisable (CD4<sup>pos</sup>Tim-3<sup>pos</sup>PD-1<sup>pos</sup>: 0.7±0.1; CD8<sup>pos</sup>Tim-3<sup>pos</sup>PD-1<sup>pos</sup>: 1.7±0.4), they are reduced in AIH (CD4<sup>pos</sup>Tim-3<sup>pos</sup>PD-1<sup>pos</sup>: 0.4±0.1, p=0.007; CD8<sup>pos</sup>Tim-3<sup>pos</sup>PD-1<sup>pos</sup>: 0.9±0.3, p=0.03). <h3>Conclusion</h3> AIH patients have fewer PD-1 and Tim3 positive cells within both CD4 and CD8 T cells. Defective expression of these negative immune-regulatory molecules may contribute to breakdown of tolerance, possibly accounting for the initiation and/or perpetuation of the autoimmune liver attack. <h3>Competing interests</h3> None declared.
Blinding Endophthalmitis from Orthodontic Headgear
Authors: Tami Blum-Hareuveni, Uri Rehany, Shimon Rumelt
Journal: New England Journal of Medicine (2004)

To the Editor: Intraocular infection (endophthalmitis) is a serious risk after a penetrating injury to the eye and may result in blindness. We report a severe intraocular infection from an eye injury caused by an orthodontic extraoral traction device (orthodontic headgear). A 12-year-old boy who was being treated for malocclusion with orthodontic headgear without safety features had an accidental release of the device, which apparently struck his right eye while he was sleeping. The patient reported pain in his right eye on awakening. His visual acuity was 20/60. A corneal laceration was found. The posterior segment of the eye appeared . . .
PTH-049 Sub-Optimal Bowel Preparation in the Surveillance Population - what Does it Mean?: Abstract PTH-049 Table 1
Authors: R J Mead, Y C Lim, E Cameron
Journal: Gut (2013)

<h3>Introduction</h3> Modern colonoscopic surveillance follows clear evidence based guidelines, and clinical decisions appear straight forward. However, the guidelines do not define what should be done in cases with sub-optimal preparation. <h3>Methods</h3> We retrospectively reviewed all adenoma and post carcinoma surveillance colonoscopies over 5 years (2006–2011) with a further year follow up looking for incident cancers. Polyp site, number, size, and colonoscopy completion rates were recorded. Two cleaning regimes were used: standard - Fleet; second line and in older patients/renal failure - KleanPrep, picolax and senna. Preparation was graded by the performing colonoscopist as satisfactory, sub-optimal or unsatisfactory. <h3>Results</h3> 2176 patients underwent 2649 surveillance colonoscopies. Average patient age was 68.8 years. Mean follow up was 3.4 years. 3758 polyps were identified in 1539 procedures; 525 polyps were 1cm or larger. There was a marked trend towards lower polyp detection with worsening bowel preparation (p = 0.056 Chi<sup>2</sup>) with a marked reduction in mean number of polyps particularly on the right side with worsening preparation. 12 colorectal cancers were detected in this population. The overall cancer rate in this high risk population was 1 in 181 patients (95% C.I. 103 – 350). 73 patients with sub-optimal or unsatisfactory preparation had a repeat colonoscopy. In 64% the preparation was satisfactory, 28% were sub-optimal, and 8% had an un-satisfactory examination. <h3>Conclusion</h3> 15% of procedures in our surveillance population have sub-optimal or un-satisfactory bowel preparation, making the interpretation of the clinical guidelines difficult. Patients who have sub-optimal or unsatisfactory preparation have a high proportion of further sub-optimal or unsatisfactory procedures. Endoscopy units should have a strategy for improving this. In patients with sub-optimal or unsatisfactory bowel preparation there is a significant reduction in overall polyp detection which is particularly marked in the right colon. This does not appear to be the case with larger polyps. In patients with sub-optimal or unsatisfactory preparation undergoing a complete colonoscopy, shorter surveillance intervals should be considered taking other patient related factors into account. <h3>Disclosure of Interest</h3> None Declared.
Treatment of relapsing acute promyelocytic leukemia by all-trans retinoic acid therapy followed by timed sequential chemotherapy and stem cell transplantation
Authors: X Thomas, H Dombret, C Cordonnier, A Pigneux, C Gardin, A Guerci, A Vekhoff, A Sadoun, A Stamatoullas, N Fegueux, F Maloisel, JY Cahn, O Reman, N Gratecos, C Berthou, F Huguet, P Kotoucek, P Travade, A Buzyn, T de Revel, JP Vilque, P Naccache, C Chomienne, L Degos, P Fenaux
Journal: Leukemia (2000)
Plasma Volume in Men with Essential Hypertension
Authors: Robert C. Tarazi, Edward D. Frohlich, Harriet P. Dustan
Journal: New England Journal of Medicine (1968)

Plasma volume (RISA) was measured in 37 men with essential hypertension uncomplicated by cardiac or renal failure, and results compared with values obtained in 20 normal male subjects. Body height was found to be a better reference index than weight for expressing results, but conclusions were identical whatever the frame of reference used. Plasma volume was diminished in hypertensive men. This decrease was greater the higher the diastolic pressure (r equal to -0.434; p less than 0.01), so that it was only evident in the patients with diastolic blood pressures over 105 mm of mercury. Plasma volume measured 19.4 ml per centimeter in normotensive, and 19.6 ml per centimeter in hypertensive men with diastolic pressure less than 105 mm of mercury, and 16.9 ml per centimeter in those with higher blood pressure (p less than 0.02). These findings contrast with reports of expanded plasma volume in primary aldosteronism and renoprival hypertension, and emphasize the importance of diagnostic grouping in studies of hypertension.
International Experts Panel Meeting of the Italian Association of Thoracic Oncology on Antiangiogenetic Drugs for Non–Small Cell Lung Cancer: Realities and Hopes
Authors: Filippo de Marinis, Emilio Bria, Fortunato Ciardiello, Lucio Crinò, Jean Yves Douillard, Frank Griesinger, Diether Lambrechts, Maurice Perol, Suresh S. Ramalingam, Egbert F. Smit, Cesare Gridelli
Journal: Journal of Thoracic Oncology (2016)
Colonic obstruction caused by calcified hepatic hydatid cyst migrated into the left colon
Authors: A. Restivo, L. Zorcolo, G. D’Alia, M. Cabras, G. Casula
Journal: Endoscopy (2010)

We report a case of hydatid liver disease complicated by migration of an entire calcified cyst into the colon, with subsequent intestinal obstruction.
Public Health Laboratory Work (Chemistry).
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
COMPARISON OF REMOTE MAGNETIC CATHETER NAVIGATION WITH MANUAL TECHNIQUE FOR CATHETER ABLATION OF ATRIAL FIBRILLATION: A SINGLE CENTER STUDY
Authors: Shiwen Yuan, Fredrik Holmqvist, Ole Kongstad, Steen Jensen, Lingwei Wang, Erik Ljungstrom, Eva Hertervig, Rasmus Borgquist
Journal: Journal of the American College of Cardiology (2016)
Outcome of HER2-Positive (HER2+) Metastatic Breast Cancer Patients (MBC) Treated with Trastuzumab (T): An Institutional Based Review.
Authors: M. Guilhaume, V. Dieras, M. Fall, J. Pierga, P. Beuzeboc, P. Cottu, C. Simondi, M. Courbard, L. Mignot, A. Livartowski
Journal: Cancer Research (2009)

Abstract Background: HER2+ status is associated with poor prognosis, high incidence of visceral and brain metastasis. However the addition of trastuzumab to chemotherapy (CT) significantly improves survival in early and advanced breast cancer. The purpose of this retrospective study was to explore the pattern of outcome in a cohort of MBC patients treated with T-based chemotherapy in a single institution. T was approved in Europe in 2000 and in 2001 all pts had access to T according HER2+ status. Methods: Women with de novo or recurrent breast cancer treated with trastuzumab at Institut Curie between 2001 and 2006 with HER2+ status (IHC 3+ or FISH +) were identified from the Institut Curie database. Disease was classified in two groups: patients who received T upfront and those who received T after one or several CT regimens. Overall survival (OS) was defined as the time from the date of the first metastasis to the date of death or last follow-up and was estimated using the Kaplan-Meier product method. Results: The final analysis included 244 patients. Median age was 53.4 yrs (29-80). Median time from primary and first metastasis was 22 mths (0-238). Visceral metastasis were present in 153 pts (63%) and 125 pts (51%) presented multiple sites. One hundred pts (42%) developed brain metastasis during the course of disease. One hundred and sixty five pts (68%) received T as first line, 79 pts (32%) after a median of one line of CT (median 1, range 1-5). One hundred and twenty four pts (52%) received more than 3 regimens. The median overall survival was 53 mths (4-113), similar in both groups. However there is a major bias: pts with very aggressive disease not treated upfront with T not have not been offered delayed T and don't appear in the analyzed population. Patients who developed brain metastasis had a median survival of 41 mths (11-90). Complete characteristics of pts will be presented. Conclusions: The introduction of T has altered the natural history of HER2+disease. Even outside a clinical trial, our results show that the addition of T to CT improves the prognosis of MBC patients with HER2+ disease. Prolongation of T after progression with other CT appears beneficial, even in pts with a high disease burden. The high incidence of brain metastases remains an issue in such a population. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 5107.
Abstract 4795: Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function in vivo
Authors: Pedro R. Lowenstein, Jieping Yang, Nicholas Sanderson, Kolja Wawrowsky, Maria G. Castro
Journal: Cancer Research (2010)

Abstract To analyze the in vivo structure of antigen-specific immunological synapses during an effective immune response, we established brain tumors expressing the surrogate tumor antigen ovalbumin, and labeled antigen-specific anti-glioma T cells using specific tetramers. Using these techniques we determined that a significant amount of antigen-specific T cells were localized to the brain tumor and surrounding brain tissue, and a large percentage could be induced to express IFNγ when exposed to the specific ovalbumin-derived peptide epitope SIINFEKL. Detailed morphological analysis of T cells immunoreactive for tetramers in direct physical contact with tumor cells expressing ovalbumin, indicated that the interface between T cells and target tumor cells displayed various morphologies, including Kupfer-type immunological synapses. Quantitative analysis of adjacent confocal optical sections was performed to determine if the higher frequency of antigen-specific anti-glioma T cells present in animals that developed an effective anti tumor immune response, could be correlated with a specific immunological synaptic morphology. Detailed in vivo quantitative analysis failed to detect an increased proportion of immunological synapses displaying the characteristic Kupfer-type morphology, in animals mounting a strong and effective anti-tumor immune response, compared to those experiencing a clinically ineffective one. We conclude that an effective cytolytic immune response is not dependent on an increased frequency of Kupfer-type immunological synapses Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4795.
THU0344 DAS-28, SDAI and CDAI in the patients with rheumatoid arthritis and concomitant fibromyalgia
Authors: J. Toms, P. Bradna, T. Soukup, Z. Hrncir
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Composite indices DAS-28 (Disease Activity Score, assessing 28 joints), SDAI (Simplified Disease Activity Index), CDAI (Clinical Disease Activity Index) are widely used instruments for the assessment of disease activity in the patients (pts) with rheumatoid arthritis (RA), but they may not be sufficient to evaluate activity in cases of RA associated with chronic pain syndromes such as fibromyalgia (FM). <h3>Objectives</h3> To examine the FM impact on disease activity composite indices in pts with RA. <h3>Methods</h3> We examined 120 pts (29 males, 91 females) with RA on the presence of concomitant FM according the ACR criteria (1990). All the patients were examined by the same rheumatologist, assessing TJC (tender joint count), SJC (swollen joint count) and TPC (tender point count). Laboratory parameters included erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), rheumatoid factor (RF) and anti-citrullinated peptide antibody (ACPA). RA activity was evaluated by three composite indices (DAS-28, SDAI and CDAI) and functional disability by Health Assessment Questionnaire (HAQ). <h3>Results</h3> The diagnosis of FM was established in 25 (20.8%) pts with RA (RAF), 4 men and 21 women. RA and RAF pts did not differ significantly in sociodemographic characteristics (age, eduacation, marital status, RA duration), laboratory inflammatory markes, RF and ACPA seropositivity. RAF pts in comparison to RA pts were found to reach significantly higher scores in all three composite indices (DA-28 5.35±1.1 vs. 3.67±1.4, p&lt;0.0001; SDAI 31.8±10.9 vs. 13.5±10.8, p&lt;0.0001; CDAI 29.6±10.7 vs. 11.8±9.4, p&lt;0.0001) and in disability level (HAQ 1.83±0.64 vs. 0.87±0.76, p&lt;0.0001). Detailed analysis revealed that TJC and VAS-GH (patient's global health on a 100 mm visual analog scale) contributed mostly to the disease activity diferencies in RA and RAF, but doctor's global health VAS was also significantly increased in pts with RAF in comparison to RA. <h3>Conclusions</h3> Rheumatologists, using disease activity composite indices in a daily clinical practice and clinical trials, should be aware of the limitations when these indices do not reflect real inflammatory activity but result from measurements dependent on an individual patient's pain perception. <h3>Disclosure of Interest</h3> None Declared