tbuckley/cabot-search huggingface dataset:
Binding of [26-<sup>3</sup>H]-Epi-Bryostatin 4 to Protein Kinase C
Authors: Nancy E. Lewin, George R. Pettit, Yoshiaki Kamano, Peter M. Blumberg
Journal: Cancer Communications (1991)

Structure activity analysis of protein kinase C modulators may permit design of selective inhibitors of this important regulatory enzyme. Modeling suggests that the C-26 secondary hydroxyl of bryostatin is homologous to the C-20 primary hydroxyl of phorbol or the C-3 primary hydroxyl of sn-1,2-diacylglycerols (Wender, P. A.; Cribbs, C. M.; Koehler, K. F.; Sharkey, N. A.; Herald, C. L.; Kamano, Y.; Pettit, G. R.; Blumberg, P. M. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proc. Natl. Acad. Sci. USA 85:7197-7201; 1980). We have characterized the binding activity to protein kinase C of the epimer of bryostatin 4 with the configuration at C-26 inverted from R (natural configuration) to S. The Kd of [26-3H]-epi-bryostatin 4 for protein kinase C reconstituted in the presence of phosphatidylserine was 13 +/- 2 nM. [26-3H]-Epi-bryostatin 4 thus retained moderate absolute affinity. Relatively, however, inversion at the chiral center at C-26 caused a dramatic decrease in binding affinity. Binding of [26-3H]-epi-bryostatin 4 was competitively inhibited by phorbol 12,13-diacetate, as expected for ligands that interact at the same binding site.
Shaft Fractures of Tibia: Etiology of Poor Results in Consecutive Series of 173 Fractures
Authors: G C BAUER, P EDWARDS, P H WIDMARK
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic value of circulating tumor cells (CTC) in metastatic breast cancer (MBC): Correlation with immunohistochemically defined molecular subtypes and metastatic disease sites.
Authors: A. Giordano, M. Giuliano, L. Hsu, B. C. Handy, N. T. Ueno, E. Andreopoulou, R. H. Alvarez, V. Valero, G. N. Hortobagyi, M. Cristofanilli
Journal: Journal of Clinical Oncology (2010)

1000 Background: Detection of ≥ 5 CTC per 7.5 mL of blood before treatment is an independent predictor of progression-free survival and overall survival (OS) in MBC. Correlating CTC with hormone receptor (HR), HER2 status and metastatic disease sites might identify subgroups of patients (pts) at highest risk of death and groups that benefit from prognostic evaluation by CTC. Methods: We retrospectively analyzed 516 consecutive MBC pts treated between September 2004 and September 2009 who had baseline CTC enumeration by CellSearch and immunohistochemical evaluation of primary tumor. OS was calculated from the date of CTC measurement and analyzed with Kaplan-Meier survival plots. Cox multivariate proportional hazards model was also performed. Results: At the time of analysis 187 pts (36%) had died. The median follow-up was 12.5 months (range 1-59). Distribution of pts characteristics and median OS according to CTC are shown in Table 1. In the multivariate model, considering HR, HER2 and metastatic disease sites, pts with CTC ≥ 5 had a hazard ratio of death of 1.98 (95% CI 1.47-2.66) compared with pts with < 5 CTC. Excluding pts receiving HER2 targeted therapies, CTC prognostic value was independent of subtype and disease site. Conclusions: CTC strongly predict survival in different subtypes of MBC. Furthermore, pts with HR+ disease and metastatic disease that include bone involvement benefited the most from CTC prognostic evaluation. Prospective clinical trials including such patients should consider CTC risk stratification. Patients No. (%) Median OS (months) Log-rank test Subgroups N < 5 CTC ≥ 5 CTC < 5 CTC ≥ 5 CTC P value Overall 516 310 (60.1) 206 (39.9) 30.4 18.7 <0.001 HER2-/HR+ 290 162 (55.9) 128 (44.1) 34 20.5 <0.001 HER2+/HR+ 49 32 (65.3) 17 (34.7) N/A N/A 0.064 HER2+/HR- 51 33 (64.7) 18 (35.3) 19.7 23 0.899 Triple negative 124 82 (66.1) 42 (33.9) 17.8 11.1 0.01 Visceral metastasis 319 188 (58.9) 131 (41.1) 22.1 13.6 <0.001 No bone met. 107 79 (73.8) 28 (26.2) 19.7 19.6 0.616 Bone met. 212 109 (51.4) 103 (48.6) 22.1 11.7 <0.001 No visceral metastasis 197 122 (61.9) 75 (38.1) N/A 24.6 0.029 Bone-only Metastasis 129 67 (51.9) 62 (48.1) N/A 24.6 0.009 No significant financial relationships to disclose.
Management of Brain Metastases in <i>ALK</i>-Positive Non–Small-Cell Lung Cancer
Authors: Chad G. Rusthoven, Robert C. Doebele
Journal: Journal of Clinical Oncology (2016)

The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors' suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.A 54-year-old man with a former 15-pack-year smoking history presents with cough and dyspnea. Initial work-up with imaging demonstrates a right suprahilar mass measuring 4.7 cm as well as several enlarged hilar and ipsilateral mediastinal lymph nodes. Bronchoscopy with biopsy reveals adenocarcinoma consistent with a lung primary. Staging with positron emission tomography/computed tomography (PET/CT) reidentifies the primary mass and lymph nodes and shows several PET-avid bone metastases. Brain magnetic resonance imaging (MRI) demonstrates a 1.6-cm right parietal mass with mild vasogenic edema and four additional brain metastases measuring 4 to 9 mm in size. Molecular testing is positive for an anaplastic lymphoma kinase (ALK) gene rearrangement using fluorescence in situ hybridization and negative for EGFR, ROS1, RET, BRAF, KRAS, and other oncogenes. The patient denies any neurologic symptoms and has no significant findings on neurologic exam. He is referred to you for management options for newly diagnosed stage IV (T2aN2M1b) lung adenocarcinoma.
Fifty years after Freud: Dora, the Rat Man, and the Wolf-Man
Authors: P Buckley
Journal: American Journal of Psychiatry (1989)

Three of Freud's case histories are reviewed and reexamined from the perspective of modern psychodynamic thinking. The Dora case illuminates advances in our understanding of adolescent psychology and countertransference. The cases of the Rat Man and the Wolf-Man draw attention to our increased awareness since Freud of the importance of the therapeutic relationship and the recognition that a two-person psychology is at work in the psychotherapeutic situation. The heuristic value of such comprehensive case reports is emphasized.
Hormone-Induced Tumors. I. Hamster Flank-Organ and Kidney Tumors In Vitro&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: F. Thomas Algard
Journal: JNCI Journal of the National Cancer Institute (1960)

Evidence derived from tissue-culture studies of an estrogen-induced dependent neoplasm of the kidney and an androgen-estrogen-induced dependent tumor of the flank organ in Syrian hamsters suggests that both are of epithelial origin. Cells from these hormone-dependent tumors can be grown in hormone-free media; the addition of crystalline hormone does not enhance growth or survival. However, when the kidney tumor is cultured as an “organ” fragment, growth does not occur, and survival time is greatly reduced unless estrogen is present in the culture medium. Responses to doses of 5, 10, and 25 µg. of diethylstilbestrol per ml. of culture medium indicate a graded effect—more mitoses occur at the higher value.
Judge condemns “widespread incompetence” in IVF sector
Authors: Clare Dyer
Journal: BMJ (2015)

We release here the <i>fluxweb</i> package (https://github.com/gauzens/fluxweb.git) which merges allometric theory [1] with food web energetics methods [2, 3] to provide a set of functions that estimate energy fluxes in complex food webs based on easily accessible ecological informations. Overall, the <i>fluxweb</i> package offers some tools for research on quantitative food webs and ecosystem functions, which facilitates novel research on ecosystem functions in real and dynamic natural landscapes.
Clinical Usefulness of a Novel Freehand 3D Imaging Device for Radio-Guided Intraoperative Sentinel Lymph Node Detection in Malignant Melanoma
Authors: Lena Sulzbacher, Markus Klinger, Christine Scheurecker, Michael Wacha, Andreas Shamiyeh, Michael Malek, Patrick M. Colletti, Domenico Rubello, Michael Gabriel
Journal: Clinical Nuclear Medicine (2015)

Introduction Patients with invasive malignant melanoma are commonly referred for sentinel lymph node (SLN) detection. A recently proposed 3D tomographic imaging modality is freehand SPECT (declipseSPECT). This "bedside system" was originally developed to enable minimal-invasive image-guided surgery. The aim of this retrospective analysis was to assess the clinical use of this freehand detector device for image-guided lymphatic mapping in melanoma patients. Materials and Methods Thirty-nine patients (12 female and 27 male subjects) were included (age, 30–79 years). All of them had at least one location of melanoma with tumoral stage pT1b or greater in 37 and pTx in 2 patients in different sites of the body (abdomen in 4, back in 14, head and neck in 5, lower extremity in 6, and upper extremity in 10 patients). Lymphoscintigraphy was performed with 65 to 127 MBq 99mTc-nanocolloid. A 2-day protocol was applied with SPECT-CT acquisition (Brightview XCT, Philips) at day 1 and surgery using radio-guided freehand SPECT at day 2. SPECT-CT data were integrated into the 3D navigation system to enable fast and direct localization of the SLN by displaying the depth of the node from the skin surface and lateral margins in relation to the gamma probe. Results Comparable preoperative imaging and intraoperative localization was observed in 18 patients. In 14 cases, more lymph nodes were resected than detected by SPECT-CT including 1 patient without evidence of an SLN because this node was located close to the primary right ear tumor. In 10 of these patients, intraoperative freehand SPECT revealed additional sites of lymph nodes. In 7 cases, more findings were detected by SPECT-CT than surgically removed. The procedure was safe and easy to perform, and the time of surgical intervention using freehand SPECT was in the range of 36 to 133 minutes (mean time, 66.56 minutes). Conclusions Freehand SPECT detected more SLN compared with SPECT-CT, and the tracking system provided precise anatomical localization of the radioactive-labeled SLNs.
EPI-06GERMLINE MUTATIONS IN GLIOBLASTOMA MULTIFORME (GBM) ASSOCIATED WITH AUTISM SPECTRUM DISORDER (ASD): CASE REPORT AND LITERATURE REVIEW
Authors: Pournima Navalkele, Elizabeth Varga, Kellie Haworth, Scott Coven, Diana S. Osorio, Mohamed S. AbdelBaki, Jeffrey Leonard, Daniel R. Boue', Christopher R. Pierson, Jonathan L. Finlay
Journal: Neuro-Oncology (2016)
Family Planning for the Mentally III
Authors: Henry Grunebaum
Journal: American Journal of Psychiatry (1979)

An increase in the birth rate among mentally ill women and the fact that pregnancy and childcare often exacerbate psychotic and depressive events, indicate a need for family planning services for mentally ill patients. These services should be integrated with various mental health programs because of the special attention and time required when working with mentally ill clients. An example of a coordinated family planning and mental health program exists in Massachusetts where family planning services were instituted in 3 state mental hospitals, in both community and private hospitals with psychiatric wards, and in a mental health guidance center. Follow-up studies show significant contraceptive continuation rates after the patient has been discharged from the hospital.
Results of the dexamethasone suppression test in psychiatric patients with and without weight loss
Authors: G I Keitner, W A Brown, C B Qualls, R J Haier, K T Barnes
Journal: American Journal of Psychiatry (1985)

Rates of nonsuppression on the dexamethasone suppression test were compared in 32 psychiatric inpatients with reported weight loss and 32 psychiatric inpatients without weight loss who were matched for age, sex, and diagnosis. There was no significant difference in rate of nonsuppression.
Abstract 2885: Clinical Profiles of Patients Undergoing Off-Pump Coronary Artery Bypass Graft Surgery: The California Coronary Artery Bypass Graft Surgery Outcomes Reporting Program
Authors: Zhongmin Li, Khung-Keong Yeo, Geeta Mahendra, Ezra A Amsterdam
Journal: Circulation (2007)

Objective: To compare the clinical and procedural characteristics, and operative mortality in patients undergoing off-pump coronary artery bypass surgery (OPCAB) and conventional coronary bypass surgery (CCB) among California hospitals, using data from the 2003 and 2004 California Coronary Artery Bypass Graft Surgery (CABG) Outcomes Reporting Program (CCORP). Methods: State mandated data from 121 hospitals that performed isolated CABG during 2003 and 2004 were analyzed, excluding patients with emergent or prior CABG. Patient characteristics associated with OPCAB were identified by multivariate logistic regression analysis. Predicted mortality was calculated using a multivariate model. Correlation between hospital OPCAB volume, OPCAB/CCB volume ratio and hospital risk-adjusted mortality rates was assessed. Results: OPCAB comprised 23% (8,139) of all isolated CABGs, with significant variation in volume among hospitals (median: 29; range 0–1,065). OPCAB was less likely in Caucasians compared with non-Caucasians (adjusted odds ratio [AOR]=0.85, 0.80–0.90), diabetics compared with nondiabetics (AOR 0.93, 0.87–0.98), those with myocardial infarction (MI) 1–7 days prior to CABG compared to no MI (AOR 0.87, 0.81–0.94), and in patients with ≥3 diseased vessels compared with 1 or 2-vessel disease (AOR 0.46, 0.44–0.49). However, OPCAB was more likely in those with peripheral arterial disease (PAD) compared with no PAD (AOR 1.16, 1.07–1.25), or cerebrovascular disease (CVD) compared with no CVD (AOR 1.14 1.03–1.26). OPCAB was associated with a significantly lower risk for observed operative mortality compared with CCB (1.84% vs. 2.49%, p&lt;0.0001), which persisted after adjustment for 23 preoperative factors associated with operative mortality (AOR 0.67, p&lt;0.0001). However, neither hospital OPCAB volume nor OPCAB/CCB volume ratio were associated with hospital risk adjusted operative mortality (p=0.324 and p=0.547, respectively.) Conclusion: OPCAB patients had generally better risk profiles associated with their lower predicted and observed operative mortality. But OPCAB results had no significant impact on hospital level risk-adjusted operative mortality.
The medical setting: is it beyond the psychiatrist?
Authors: J J Strain
Journal: American Journal of Psychiatry (1977)

Recent events in medicine have afforded psychiatrists an opportunity to move beyond the traditional boundaries of their involvement in the medical setting. The growing preoccupation of the medically ill and their families with the psychosocial aspects of medical illness, their growing dissatisfaction with current patterns of patient care, and internists' increased awareness of the psychological needs of the nonpsychiartic medical patient have led to a rethinking of mind-body dualism and to increased involvement of the psychiatrist in general medical care.
Combination with Thu to Address Pharmacologic Limitations of Decitabine, Interim PK/PD from a Phase 1/2 Clinical Trial of Oral Thu-Decitabine in Sickle Cell Disease
Authors: Donald Lavelle, Michel Gowhari, Michael Pacini, Lani Krauz, Johara Hassan, Vinzon Ibanez, Maria A. Ruiz, Daisy Pacelli, Chaher Alhandalous, Mitch A. Phelps, Kathleen Fenner, Reda Z. Mahfouz, John Barnard, Lewis L. Hsu, Victor R. Gordeuk, Joseph DeSimone, Yogen Saunthararajah, Robert E. Molokie
Journal: Blood (2014)
447P Efficacy of platinum-doublet chemotherapy for patients with lung cancer with epidermal growth factor receptor (EGFR) activating mutation after the failure of EGFR-tyrosine kinase inhibitors (TKIs) treatment
Authors: S. Watanabe, Y. Goto, H. Shiraishi, K. Tsuruoka, K. Yoshida, K. Itahashi, T. Asao, S. Kitahara, H. Horinouchi, S. Kanda, Y. Fujiwara, H. Nokihara, N. Yamamoto, Y. Ohe
Journal: Annals of Oncology (2015)
Surveillance of systemic invasive disease caused by group A Streptococcus in Italy 1994-1996
Authors: B Suligoi, C Von Hunolstein, G Orefici, F Scopetti, M Pataracchia, D Greco
Journal: Eurosurveillance (1998)

In late May 1994, following reports of an outbreak of group A beta-haemolytic streptococcus (GAS) in the United Kingdom, the Istituto Superiore di Sanità (ISS) set up a surveillance system for systemic invasive GAS disease. The surveillance system was als
Q fever outbreak in the village of Noćaj, Srem county, Vojvodina province, Serbia, January to February 2012
Authors: S Medić, D Nitzan Kaluski, Z Šeguljev, J Obrenović, P Rudan, M Lazarević, J Jandrić Kočić, D Sajenković, I Pušić, D Bugarski, D Vidanović, M Šekler
Journal: Eurosurveillance (2012)

From 27 January to 10 February 2012, a total of 43 cases of Q fever were notified in the village of Noćaj, Srem county, Autonomous Province of Vojvodina, Republic of Serbia. Q fever was laboratory confirmed in 37 notified cases. Alhough, the outbreak is considered over, the outbreak investigation is still ongoing in order to identify aetiologic factors relevant for this outbreak.
Associations between Source-Specific Fine Particulate Matter and Emergency Department Visits for Respiratory Disease in Four U.S. Cities
Authors: Jenna R. Krall, James A. Mulholland, Armistead G. Russell, Sivaraman Balachandran, Andrea Winquist, Paige E. Tolbert, Lance A. Waller, Stefanie Ebelt Sarnat
Journal: Environmental Health Perspectives (2016)

Background:Short-term exposure to ambient fine particulate matter (PM2.5) concentrations has been associated with increased mortality and morbidity. Determining which sources of PM2.5 are most toxic can help guide targeted reduction of PM2.5. However, conducting multicity epidemiologic studies of sources is difficult because source-specific PM2.5 is not directly measured, and source chemical compositions can vary between cities.Objectives:We determined how the chemical composition of primary ambient PM2.5 sources varies across cities. We estimated associations between source-specific PM2.5 and respiratory disease emergency department (ED) visits and examined between-city heterogeneity in estimated associations.Methods:We used source apportionment to estimate daily concentrations of primary source-specific PM2.5 for four U.S. cities. For sources with similar chemical compositions between cities, we applied Poisson time-series regression models to estimate associations between source-specific PM2.5 and respiratory disease ED visits.Results:We found that PM2.5 from biomass burning, diesel vehicle, gasoline vehicle, and dust sources was similar in chemical composition between cities, but PM2.5 from coal combustion and metal sources varied across cities. We found some evidence of positive associations of respiratory disease ED visits with biomass burning PM2.5; associations with diesel and gasoline PM2.5 were frequently imprecise or consistent with the null. We found little evidence of associations with dust PM2.5.Conclusions:We introduced an approach for comparing the chemical compositions of PM2.5 sources across cities and conducted one of the first multicity studies of source-specific PM2.5 and ED visits. Across four U.S. cities, among the primary PM2.5 sources assessed, biomass burning PM2.5 was most strongly associated with respiratory health.Citation:Krall JR, Mulholland JA, Russell AG, Balachandran S, Winquist A, Tolbert PE, Waller LA, Sarnat SE. 2017. Associations between source-specific fine particulate matter and emergency department visits for respiratory disease in four U.S. cities. Environ Health Perspect 125:97–103; http://dx.doi.org/10.1289/EHP271
Comparing actual versus recorded height and weight measurements in oncology patients: Impact on dose accuracy and medication safety.
Authors: R. W. Lau, V. Y. Wong, M. A. Christianson, K. Birmingham
Journal: Journal of Clinical Oncology (2010)

e19625 Background: Accurate dose computation is essential for optimal treatment and medication safety, especially in oncology. Body surface area (BSA) calculated from baseline patient height (ht) and weight (wt) is used to determine first chemotherapy dose and often guides all subsequent treatments. However, ht and wt may be recorded erroneously or may change from initial measurement at any point during a chemotherapy regimen. Use of inaccurate parameters may lead to dosing errors over multiple cycles of chemotherapy, resulting in treatment failure or intolerable adverse effects. Methods: Over a three-week period, BSA was calculated for oncology patients at each cycle of chemotherapy treatment.The BSA was based on ht and wt measured by an oncology nurse at each infusion visit. A pharmacist compared these values to the most recent ht, wt, and BSA recorded in the electronic medical record. Differences in ht (± 2 inches), wt (± 5 pounds) or BSA (± 0.2) triggered the pharmacist to recalculate the chemotherapy doses. If a dose difference of 5% or greater was detected, the attending oncologist was contacted. The percentage of discrepancies and pharmacist interventions were reported. Results: A total of 89 ht and wt measurements were collected. The incidence of discrepancies between recorded and actual measurements was 11.2% (10/89). One was related to ht and nine were related to wt (discrepancy range of 3.2-49%). Five discrepancies triggered the pharmacist to contact the oncologist and two dose adjustments were approved. One adjustment resulted from a 24-pound wt difference that was not detected at the oncology clinic visit but was captured at the infusion center. The other dose adjustment occurred because the chemotherapy order was based on a wt recorded two years previously which resulted in a 20% difference in calculated BSA. Conclusions: Discrepancies can occur between recorded baseline body dimensions and measured parameters at the time of chemotherapy infusions. This study highlights the magnitude of such differences and the potential dosing errors that can occur. Patient height and weight should be measured prior to each chemotherapy cycle to ensure accurate dosing. No significant financial relationships to disclose.
MB-106PROGNOSTIC RELEVANCE OF CLINICAL AND MOLECULAR RISK FACTORS IN CHILDREN WITH HIGH-RISK MEDULLOBLASTOMA TREATED IN THE FRENCH PROSPECTIVE TRIAL PNET HR + 5
Authors: Christelle Dufour, Anne Geoffray, Laura Faivre, Franck Bourdeaut, Julien Maslian Planchon, Dominique Figarella-Branger, Cécile Faure-Conter, Céline Icher, Anne Isabelle Bertozzi, Pierre Leblond, Nicolas Sirvent, François Doz, Nicolas André, Emilie De Carli, Céline Chappe, Odile Lejars, Pascal Chastagner, Christine Soler, Claire Berger, Natacha Entz-Werlé, Marie-Bernadette Delisle
Journal: Neuro-Oncology (2016)