tbuckley/cabot-search huggingface dataset:
Abstract 3749: Polymorphisms in metabolism genes may mediate the effect of dietary intake on pancreatic cancer risk
Authors: Rick Jansen, Dennis Robinson, Rachael Stolzenberg-Solomon, William Bamlet, Julie Cunningham, David Rider, Ann Oberg, Traci Hammer, Kari Rabi, Kristin Anderson, Janet Olson, Rashmi Sinha, Gloria Petersen
Journal: Cancer Research (2011)

Abstract Background: The role of dietary fruit, vegetable, fiber, and whole grain intake is implicated as a potential protective factor against pancreatic cancer, but studies are inconsistent. A possible explanation for the variability is that individuals who carry constitutional metabolism gene variants (minor alleles) may differentially benefit compared to those who are homozygous for the major allele, which over a life-time could lead to altered pancreatic cancer risk. Methods: We genotyped 70 SNPs that tag ten candidate metabolism genes (CAT, GAA, GCK, MT1E, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2B4, and UGT2B7) involved in the metabolism of components of fruits, vegetables, fibers, and whole grains to test if differential associations exist with pancreatic adenocarcinoma. We used a clinic-based case-control design, excluding participants who reported changing their diet within 5 years prior to entering the study. Three hundred eighty-four rapidly ascertained cases and nine hundred eighty-three non-cases from a primary care clinic (frequency matched on age at recruitment (+ 5 years), race, sex, and region of residence) provided blood samples for DNA and completed epidemiologic surveys plus a 144-item food frequency questionnaire developed by the National Cancer Institute. We used a dominant model to code SNPs and split dietary intake categories based on the sex-specific median intake level among non-cases. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals, adjusted for age, sex, family-history of pancreatic cancer, smoking (never/ former/ current), body mass index, energy intake, and alcohol consumption. The reference group was defined as carriers of no minor alleles in the lowest intake category. Results: The greatest benefit was observed for carriers of no minor alleles, for rs11032702 (CAT) with higher insoluble dietary fiber intake (OR [95%CI]: 0.515 [0.37, 0.71]); for rs735670 (GCK) with higher soluble dietary intake (0.473 [0.34, 0.67]); for rs2070971 (GCK) and rs2268569 (GCK) with higher fruit intake not from citrus, melon, and berries (0.513 [0.36, 0.73] and 0.554 [0.40, 0.78]); and for rs17832252 (GCK) with higher whole grain intake (0.530 [0.37, 0.76]); all comparisons had a reference group of no minor alleles with low dietary intake and a p-value for interaction &amp;lt;0.001. Conclusions: Inter-individual variation in metabolism of fruits, vegetables, fiber, and whole grain via metabolism gene variants may influence pancreatic cancer risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3749. doi:10.1158/1538-7445.AM2011-3749
SP0139 A Tool to Identify Past or Present Rheumatoid Arthritis Flare from Both Patient and Physician Perspective
Authors: B. Fautrel
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Rheumatoid arthritis (RA) patients with unstable and fluctuating disease activity have been shown to be at risk of structural damage progression. Despite considerable efforts dedicated to the assessment of RA disease activity, no consensual definition of RA flare has been achieved. To define RA flare is challenging since patients and physicians have different perceptions with regards to flare of the disease. Patients are likely to disentangle "bad days" which are considered as part of the natural history of RA and RA flare which corresponds to the extension of such "bad days". In the patient perspective, subjective symptoms – fatigue, irritability, pain – are more valued than joint swelling. Physicians usually base their opinion of flare on physical examination – joint pain or swelling – or biologic results. To get a more consensual definition of RA flare could be useful for 2 main reasons: 1) the overall assessment of disease stability over the period between 2 medical consultations; 2) the possibility to change the schedule of medical visits depending on the presence or absence of RA flare. A tool, named FLARE-RA, has been developed to reach this goal. It is a self-administered questionnaire developed to detect rheumatoid arthritis (RA) flare that has occurred in the meantime since the last visit to the physician<sup>1</sup>. The questionnaire is based on 11 items or statements exploring both RA patients and physician perceptions of RA flare in the 3-month period before the consultation to the rheumatologist. The respondents are asked to rate their agreement on a 0-10 numerical rating scale (NRS). The final score is the mean of the 12 NRS. The FLARE-RA tool has already been shown to be unidimensional and reliable. The final score displays good correlation with disease activity at the time of questionnaire filling. In addition, it also has fair to good correlation with the overall disease activity – assessed by weekly RAPID-3 – over the 3 months preceding the medical consultation. The FLARE-RA tool is an interesting and relevant self-administered questionnaire, able to detect past or present RA disease activity increase, i.e., an RA flare. Its predictive validity – in terms of structural damage progression – still needs to be assessed. <h3>Disclosure of Interest</h3> B. Fautrel Grant/Research support from: AbbVie, MSD, NORDIC Pharma, Consultant for: AbbVie, BMS, MSD, NORDIC Pharma, Pfizer, Roche, UCB <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6340
Disappearance of a Breast Prosthesis during Pilates
Authors: Tiffany C Fong, Beatrice Hoffmann
Journal: New England Journal of Medicine (2011)

A 59-year-old woman with a history of breast cancer who had undergone bilateral mastectomy and placement of breast prostheses reported that her “body swallowed one of the implants” during a Pilates stretching exercise. The patient reported no chest pain or dyspnea.
P228 An audit of the effectiveness of competency based spirometry training
Authors: J. Shakespeare, K. Storey, D. Parr
Journal: Thorax (2011)

<h3>Introduction</h3> The PCT had funded practice nurses to undertake formal competency based training in spirometry measurements. An audit of spirometry provision in practices within the PCT was undertaken to assess equipment, training and quality of spirometry being performed with comparison made between spirometry undertaken by trained staff (ARTP Cert) and that performed by untrained staff. The aim was to assess the effectiveness of the competency based training being funded by the PCT. <h3>Methods</h3> 36 practice nurses had received training from Respiratory Physiologists based in an acute hospital trust to ARTP Full Certificate in Spirometry standards. 62 Primary Care practices were sent a questionnaire, designed by the author, and asked to supply five recent anonymous spirometry traces. <h3>Results</h3> 26 practices responded (42%); 5 (19%) did not perform spirometry testing, due to a “lack of staff skills” (4/5) and “young patient population” (1/5). Of those practices performing spirometry, all were using the Care Fusion MicroLab spirometer and the following training had been undertaken; ARTP training course (16/21), drug representative training (3/21), COPD Diploma (1/21) and no response (1/21). 81% of practices performing spirometry had a calibration syringe and performed calibration either at each session or weekly. Training for the practices that did not have a calibration syringe (19%) was by; COPD Diploma (1/4) and drug representative (3/4). 18/21 practices performing spirometry sent five traces for analysis. Only 17% practices performed relaxed VC manoeuvres and of these 66% achieved acceptability criteria. 13/18 performed the recommended minimum of three FVC9s (72%) with 11 of these (85%) achieving two results within 5% or 100 ml.1 5/18 did not perform a minimum of three manoeuvres (for three practices only one of the five traces met acceptability criteria, two of whom were ARTP spirometry trained). Two practices submitted five traces where none of the traces achieved the required acceptability criteria (both Drug Representative trained). <h3>Conclusion</h3> Training staff to ARTP standards improves the quality of spirometry performed in primary care (when compared to other modes of training), however once training is completed, it is important to audit quality standards to ensure that they are still met.
Transhepatic Catheterization and Obliteration of the Coronary Vein in Patients with Portal Hypertension and Esophageal Varices
Authors: Anders Lunderquist, Johannes Vang
Journal: New England Journal of Medicine (1974)

For the management of esophageal varices complicating portal hypertension, we have developed a method that consists of (1) percutaneous transhepatic portal venipuncture, (2) manipulation of a catheter via the portal vein into the coronary vein, and, (3) if injection of contrast medium demonstrates retrograde flow through that vein as well as esophageal varices, injection of 30 ml of 50 per cent glucose solution followed by injection of a small amount of thrombin solution. Portography is used throughout to facilitate the procedure and assess results. Four patients have been treated, two of them with variceal bleeding. In all four, obliteration of the coronary vein by this method was successful. (N Engl J Med 291:646–649, 1974)
AB0571 The study of the clinical characteristics between late-onset and early-onset spondyloarthritis
Authors: Y. Taniguchi, S. Nakayama, K. Inoue, M. Tsugita, T. Horino, Y. Kumon, Y. Terada
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Spondyloarthritis (SpA), including ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis (ReA), enteropathic arthritis, undifferentiated spondyloarthritis (uSpA), and synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome, often involves the entheses. The differences between early-onset and late-onset SpA are poorly understood. <h3>Objectives</h3> To evaluate comparatively clinical characteristics, including positron emission tomography/computed tomography (PET/CT) using <sup>18</sup>F-fluorodeoxyglucose (FDG) findings, of patients with between both early-onset and late-onset SpA in our hospital. <h3>Methods</h3> We detected SpA group that developed in less than 45 years old as early-onset SpA (EOSpA), and in more than 65 years old as late-onset SpA (LOSpA). The clinical symptoms, laboratory findings and the results of PET/CT scans of twenty patients with EOSpA and twenty LOSpA were comparatively examined. <h3>Results</h3> LOSpA had fever, body weight loss and severe systemic symptoms. Three of LOSpA (3/20) developed PMR-like symptoms. LOSpA showed significantly higher inflammatory reaction than EOSpA. Images of PET/CT scans revealed widespread FDG accumulations at the entheses in LOSpA patients, in comparison with EOSpA. The maximum SUVs were statistically higher in LOSpA patients compared EOSpA patients at the entheses (<i>P</i> &lt; 0.05). Furthermore, three of LOSpA (3/20) had peripheral edema in lower extremities, and it pathologically showed panniculitis. There were no significant differences in HLA typing between EOSpA and LOSpA. <h3>Conclusions</h3> LOSpA revealed severe clinical symptoms, inflammatory reactions, and widespread and strong enthesitis and arthritis compared with EOSpA. It is important to differentiate SpA, RS3PE syndrome and PMR in cases with peripheral edema, myalgia and pantalgia. We must investigate further cases of LOSpA in order to elucidate its pathophysiology and mechanisms of development. <h3>Disclosure of Interest</h3> None Declared
Expression of H-Y Antigen in Human Males with Two Y Chromosomes
Authors: Stephen S. Wachtel, Gloria C. Koo, W. Roy Breg, Sherman Elias, Edward A. Boyse, O. J. Miller
Journal: New England Journal of Medicine (1975)

To determine whether the gene that controls the expression of H-Y ("male") antigen on human cells is Y-linked, we have compared the H-Y antigen level in normal males with that in three males with two Y chromosomes. Leukocytes from one XXYY and two XYY males express more H-Y antigen than leukocytes from normal XY males. We conclude that a structural gene or positive regulatory gene for H-Y antigen is on the human Y chromosome. Testing for the H-Y antigen may be of benefit in patients who have signs of masculinization but who lack an identifiable Y chromosome. Positive results for the H-Y antigen would be tentative evidence that the corresponding region of the Y chromosome was present, perhaps as part of a translocation, despite the absence of a typical Y chromosome.
Abstract 745: Structure-activity relationship study of the novel aspirin-based anticancer compounds
Authors: Stancy J. Joseph, Ting Nie, Francis Johnson, Ramesh Gupta, Basil Rigas
Journal: Cancer Research (2010)

Abstract We performed a structure-activity relationship (SAR) study of novel derivatives of aspirin (ASA) which show strong anticancer activity in vitro and in vivo. We synthesized a series of ASA-based benzyl esters (ABEs) and evaluated their inhibitory activity against human colon (HT-29 and SW480) and pancreatic cancer cell lines (BxPC-3 and MIA PaCa-2). The ABEs that we studied largely comprise organic benzyl esters bearing an ASA or acyloxy group (X) at the meta or para position of the benzyl ring and one of four different leaving groups. The nature of the salicyloyl/acyloxy function, the leaving group, and the additional substituents affecting the electron density of the benzyl ring, all were influential determinants of the cancer cell growth inhibitory activity of each ABE. Positional isomerism also played a significant role in this effect. Our SAR study provides an insight into the biological properties of this novel class of compounds and underscores their potential as anticancer agents. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 745.
AB1192 Epidemiology of juvenile idiopathic artritis-associated uveitis in spain: Results from a national registry
Authors: R. Bou, C. García de Vicuña, I. Calvo, E. Nuñez, B. Bravo, M. Camacho, S. Bustabad, M.J. Rúa, P. Solís, C. Calvo, V. Hernandez, L. Carmona, J. Antόn
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Uveitis is one of the major extra-articular manifestations of Juvenile Idiopathic Arthritis (JIA), appearing in 10-30% of these patients. Most cases of uveitis in JIA patients are asymptomatic, bilateral and recurrent, representing a challenge for ophthalmologists and pediatric rheumatologists given its aggressiveness and frequent complications. For this reason, during the first national meeting of JIA-associated uveitis (Barcelona, 2008), a working group was established to provide a consensus protocol for follow-up and treatment of these patients, as well as designing a national database. <h3>Objectives</h3> The aim of this paper is to analyze the characteristics of patients with JIA-associated uveitis included in this multicenter registry. <h3>Methods</h3> Retrospective analysis of medical records of patients with JIA-associated uveitis in 10 centers in Spain, from databases of ophthalmology and/or pediatric rheumatology units at each center. We collected epidemiological, clinical, and in some centers follow-up and treatment parameters. <h3>Results</h3> A total of 152 patients were collected, 77% of whom were women, 80% had positive antinuclear antibodies (ANA) and 20% were HLA-B27 positive. The most frequent subtype of JIA presenting uveitis was oligoarticular (76%), followed by polyarticular (11%) and it was anecdotally observed in enthesitis related arthritis (5%), psoriatic arthritis (5%) and undifferentiated arthritis (2.5%). No patient with uveitis had systemic onset JIA. Around 90% of patients had anterior uveitis and 55% were bilateral. The mean age at diagnosis of JIA was 3.7±3.1 years. In 13% of patients uveitis was diagnosed before the onset of JIA and in 48% at the time of diagnosis of JIA or during the first year. In 44 patients (29%) data of complications were registered, of which 27 had synechiae, 23 cataracts, 16 band keratopathy, 11 cystoid macular edema and 5 glaucoma. As for treatments used for uveitis and/or arthritis: 140 patients received methotrexate, 65 adalimumab, 34 etanercept, 15 infliximab and 5 abatacept. <h3>Conclusions</h3> Most patients with uveitis are girls with positive ANA oligoarticular JIA subtype, with chronic anterior uveitis, and bilateral localization in more than half of cases. Although 13% of patients presented uveitis before arthritis and therefore were at increased risk of complications, we emphasize the need for periodic eye screening in all patients diagnosed with JIA, according to the risk to the subtype of JIA, presence of ANA, age and years since onset of arthritis. We also want to stress the importance of multicenter data collection, which allows a better evaluation of these patients and the possibility of designing prospective studies. <h3>Disclosure of Interest</h3> None Declared
Abstract 1342: Roles for CD40 ligation in tumor-macrophage interaction and tumor metastasis
Authors: Katharine S. Richardson, Courtney George, Jill Suttles, Robert Stout
Journal: Cancer Research (2010)

Abstract Macrophages are now known to play multiple roles in the progression and metastasis of many solid tumors. Although tumor-derived cytokines play a role in stimulating cytokine production by the macrophages, the extent of tumor-macrophage cross-talk remains to be explored. We have previously demonstrated that CD154:CD40 interactions are a dominant mechanism of contact-dependent communication between a variety of cell types. We therefore initiated a study of the role of CD154:CD40 interactions in tumor-macrophage interactions. Flow cytometric analysis reveals CD154 expression on 3LLC carcinoma cells. In corroboration of previous studies, co-culture of supernatants of tumor cell cultured with normal macrophages stimulated moderate cytokine production and this was equally effective with both CD40+/+ and CD40-/- macrophages. Co-culture of paraformaldehyde-fixed tumor cells with normal macrophages stimulated cytokine production by the macrophages, indicating that a cell contact dependent mechanism was also involved in the stimulation of macrophages by the tumor cells. Implantation of 3LLC tumors subcutaneously in CD40+/+ and CD40-/- mice resulted in similar growth of the primary tumor mass. However, no lung metastases were detectable in the CD40-/- mice. Bone marrow chimeric mice were generated by reconstituting irradiated CD40+/+ mice with either CD40+/+ or CD40-/- bone marrow. Nine weeks later, the splenic and peripheral blood leukocytes were &amp;gt;94% donor derived. Both recipients of CD40+/+ and CD40-/- bone marrow displayed similar growth of the primary tumor and similar frequency of lung metastases, indicating that CD40 expression by bone marrow derived macrophages was not critical for tumor metastasis. The study demonstrates that ligation of CD40 on hematopoietic and non-hematopoietic cells may play critical roles in tumor progression and metastasis. This research was supported by grants from the Kentucky Lung Cancer Foundation (J.S.) and the Susan G. Komen Race for the Cure (R.S.) and by an NRSA T32 Postdoctoral Training Grant (K.R.) and a Ruth Kirschstein T31 Predoctoral Fellowship (C.G.). Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1342.
Acute Hemolytic Anemia in Primary Atypical Pneumonia Associated with High Titer of Cold Agglutinins
Authors: Harold S. Ginsberg
Journal: New England Journal of Medicine (1946)

SEVERAL observers1 2 3 4 have reported cases of acute anemia occurring in patients with primary atypical pneumonia who have developed high titers of cold agglutinins (autohemagglutinins). Since all these patients, with 2 possible exceptions, had been given one of the sulfonamide drugs, an additional etiologic factor was present that these authors thought might have been the primary or a contributory cause of the hemolytic crisis.† In the case reported below, no sulfonamide drug or any other medicinal agent was used that could have been an etiologic factor responsible for the causation of the acute hemolytic anemia.Case ReportThe patient, a 34-year-old . . .
Abstract LB-356: Characterization of microRNA expression of clear cell renal cell carcinoma by whole genome small RNA deep sequencing using human tissue cohort
Authors: Huiqing Wu, Lihong Weng, Xiwei Wu, Hanlin Gao, Bing Mu, Xuejun Li, Jennifer Jin, Jin-hui Wang, Chao Guo, Zhuo Chen, Lawrence Weiss
Journal: Cancer Research (2010)

Abstract Introduction: MicroRNA (miRNA) is a group of small non-coding regulating RNA and has shown altered expression in cancer. With great advantages in test specificity and capability to detect novel (unknown) miRNA and other small RNA targets, the next-generation deep sequencing technology is replacing microarray platforms, at least in the discovery phase. Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney malignancies and one of the leading causes of death. Characterizing miRNA expression of ccRCC will enhance the understanding of its tumorigenesis and progression and will, therefore, lead to the development of cancer-specific molecular therapy. In this study, we analyzed miRNA expression using a human ccRCC cohort by whole genome small RNA deep sequencing. We characterized the miRNA expression in association with CCRCC and further validated the altered miRNA expression in a larger clinical cohort by RT-PCR. A group of tumor associated novel miRNAs have been discovered. Design: (1) Deep sequencing of whole genome small RNA (17-52 nucleotides in size) in a 6-sample frozen CCRCC cohort (3 benign and 3 ccRCC samples) using Illumina system (Solexa) was performed. (2) The miRNA expression of benign kidney and ccRCC samples was quantitatively compared. (3) 8 miRNAs, which were randomly selected from the list of top 20 aberrantly expressed miRNAs detected by deep sequencing, were tested using ABI RT-PCR technology in a 38-sample ccRCC cohort (9 benign kidney and 29 different stage ccRCC samples) for validation. (4) Analysis of unknown small RNAs was performed to find tumor associated novel miRNAs. Results: (1) Using a deep sequencing technology, we detected miRNAs and other small RNAs in frozen human samples of ccRCC cohort and successfully profiled miRNA expression in association with tumor. (2) We validated the altered expression of 8 selected miRNA targets in the 38-sample clinical ccRCC cohort using an RT-PCR method. (3) We discovered a group of novel miRNAs associated with ccRCC. Conclusions: We performed whole genome small RNA deep sequencing of human ccRCC tissue with further RT-PCR validation in a clinical sample cohort. We have characterized miRNA expression and discovered a group of novel miRNAs in association with ccRCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-356.