tbuckley/cabot-search huggingface dataset:
Efficacy of High-Dose Therapy and Autologous Hematopoietic Cell Transplantation in Peripheral T-Cell Lymphomas As Front-Line Consolidation or in the Relapsed/Refractory Setting: A Meta-Analysis
Authors: Jessica El-Asmar, Tea Reljic, Ernesto Ayala, Taiga Nishihori, Mehdi Hamadani, Ambuj Kumar, Mohamed A. Kharfan-Dabaja
Journal: Blood (2015)
Differences in Hemoglobin A1c Between Hispanics/Latinos and Non-Hispanic Whites: An Analysis of the Hispanic Community Health Study/Study of Latinos and the 2007–2012 National Health and Nutrition Examination Survey
Authors: M. Larissa Avilés-Santa, Lucy L. Hsu, Mario Arredondo, Andy Menke, Ellen Werner, Bharat Thyagarajan, Gerardo Heiss, Yanping Teng, Neil Schneiderman, Aida L. Giachello, Linda C. Gallo, Gregory A. Talavera, Catherine C. Cowie
Journal: Diabetes Care (2016)

To determine whether, after adjustment for glycemia and other selected covariates, hemoglobin A1c (HbA1c) differed among adults from six Hispanic/Latino heritage groups (Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American) and between Hispanic/Latino and non-Hispanic white adults without self-reported diabetes.We performed a cross-sectional analysis of data from 13,083 individuals without self-reported diabetes from six Hispanic/Latino heritage groups, enrolled from 2008 to 2011 in the Hispanic Community Health Study/Study of Latinos, and 2,242 non-Hispanic white adults enrolled during the 2007-2012 cycles of the National Health and Nutrition Examination Survey. We compared HbA1c levels among Hispanics/Latinos and between Hispanics/Latinos and non-Hispanic whites before and after adjustment for age, sex, fasting (FPG) and 2-h post-oral glucose tolerance test (2hPG) glucose, anthropometric measurements, and selected biochemical and hematologic variables and after stratification by diabetes status: unrecognized diabetes (FPG ≥7.1 mmol/L or 2hPG ≥11.2 mmol/L), prediabetes (FPG 5.6-7.0 mmol/L or 2hPG 7.8-11.1 mmol/L), and normal glucose tolerance (FPG <5.6 mmol/L and 2hPG <7.8 mmol/L).Adjusted mean HbA1c differed significantly across all seven groups (P < 0.001). Non-Hispanic whites had significantly lower HbA1c (P < 0.05) than each individual Hispanic/Latino heritage group. Upon stratification by diabetes status, statistically significant differences (P < 0.001) in adjusted mean HbA1c persisted across all seven groups.HbA1c differs among Hispanics/Latinos of diverse heritage groups and between non-Hispanic whites and Hispanics/Latinos after adjustment for glycemia and other covariates. The clinical significance of these differences is unknown.
P-231 All RAS mutation predict for poor clinical outcomes after metastasectomy in patients with metastatic colorectal cancer
Authors: H. Osumi, E. Shinozaki, M. Suenaga, Y. Kumekawa, M. Ozaka, M. Ogura, S. Matsusaka, K. Chin, M. Ueno, A. Saiura, S. Okumura, N. Mizunuma, Y. Miki, T. Yamaguchi
Journal: Annals of Oncology (2015)
An Effect of &lt;italic&gt;N&lt;/italic&gt;-2-Fluorenylacetamide on the Metabolism of Tryptophan in Rats&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Helen M. Dyer, Harold P. Morris
Journal: JNCI Journal of the National Cancer Institute (1961)

Rats ingesting N-2-fluorenylacetamide (2-FAA) in a diet adequate for their maintenance and growth excrete in the urine increased amounts of free and/or conjugated xanthurenic acid, kynurenic acid, and hydroxylated kynurenine after a challenging dose of l-tryptophan. The rats excrete considerably less, or no detectable amounts, of these metabolites of tryptophan, if they are given small supplements of pyridoxine. This effect of 2-FAA is dependent on the concentration of the carcinogen in the diet, the amount of dietary pyridoxine, and the amount of tryptophan used for challenge. In repeated tests from the 10th to the 90th day of feeding there appeared to be no noticeable increase in the effect. During the early precancerous period when these tests were made, no macroscopic changes were usually seen in the liver, and no clinical evidence of B6 deficiency was observed. Ingestion of carcinogenic amounts of N-2-fluorenyldiacetamide, a potent liver carcinogen, also interfered with the normal metabolism of a load dose of tryptophan, whereas the nonhepatocarcinogen, N-(7-hydroxy - 2 - fluorenyl) - acetamide, even at twice the molar equivalent level, had no apparent effect. There is indirect evidence that the accumulation of increased amounts of xanthurenic acid, kynurenic acid, and kynurenine derivatives may be due to an inhibition of kynureninase activity resulting from combination of the coenzyme pyridoxal phosphate with fluorenamine or some other amino metabolite of 2-FAA. Excess kynurenine coming from a tryptophan challenge may also inhibit kynureninase activity. The findings suggest that more than the ordinary requirement of vitamin B6 may be needed by rats ingesting amino carcinogens.
Rapid Prenatal Diagnosis of Glycogen-Storage Disease Type II by Electron Microscopy of Uncultured Amniotic-Fluid Cells
Authors: George Hug, Shirley Soukup, Mary Ryan, Gail Chuck
Journal: New England Journal of Medicine (1984)

Glycogen-storage disease Type IIa is a fatal, genetically determined disease of infancy or early childhood that is characterized by deficient activity of acid alpha-glucosidase and by the presence of intracellular vacuoles full of glycogen, which are found in most tissues, including skin and liver. On electron microscopy these specific vacuoles are tightly packed accumulations of glycogen particles surrounded by a single membrane. We did electron-microscopical examinations on uncultured amniotic-fluid cells from 26 women whose fetuses were at risk for glycogen-storage disease Type IIa and from 8 normal control pregnant women. We found specific vacuoles in cells from 6 of the 26 high-risk patients. At delivery, glycogen-storage disease Type IIa was present in the infants of these 6 women and absent in those of the other 20 according to results of clinical, biochemical, and electron-microscopical studies of gestational products. After amniocentesis at 15 to 18 weeks of gestation, the prenatal diagnosis made by electron microscopy of uncultured amniotic-fluid cells was available in three to six days, whereas it took from three to six weeks to make the diagnosis by enzymatic analysis of the cultured amniotic-fluid cells. We conclude that the electron-microscopical prenatal diagnosis of glycogen-storage disease Type IIa is rapid, safe, and reliable. It should facilitate earlier diagnosis and thereby help to preserve parental options.
Rebamipide liquid to prevent radiation-induced oral mucositis via attenuation of pro-inflammatory signaling.
Authors: Naoya Uematsu, Takako Nakashima, Takakuni Matsuda, Nobutomo Sako, Kazushi Sakurai
Journal: Journal of Clinical Oncology (2015)

e20719 Background: Rebamipide liquid is being studied under clinical phase II trial for the prevention and treatment of oral mucositis in patients receiving chemoradiotherapy for head and neck cancer. In a pilot study, the severity of oral mucositis in oral cancer patients was decreased with rebamipide-treated subjects (Yasuda 2012). However, the underlying mechanisms of rebamipide on the oral mucositis prevention are not fully understood. Recently, we reported that biphasic elevation of pro-inflammatory cytokines was observed during the glossitis development in rats (Nakashima 2013). In this study, we examined further molecular mechanisms of rebamipide focusing on its anti-inflammatory actions using the rat model and human gingival fibroblasts (HGF). Methods: Rebamipide liquid was intraorally administered for 7 days before X-ray irradiation (Day 0), and RNA was extracted from the tongue at 6h after the irradiation to perform a genome-wide expression analysis. The expression data were subjected to a pathway analysis to find out the differential networks as compared to vehicle control. In addition, the expression levels of mRNAs and proteins found in the pathway analysis were evaluated at the ulceration phase (Day7) in the rat model. HGF was used to evaluate the effect of rebamipide on TNF-α-stimulated inflammatory response. Results: The gene expression data showed that NF-κB signaling was activated at 6h after the X-ray irradiation. The pathway analysis also revealed that rebamipide liquid could suppress TNF-α-mediated IL6 and CXC chemokines in this stage. In vitro study confirmed that the pretreatment of rebamipide attenuated the production of TNF-α-induced cytokines in a concentration-dependent manner. Furthermore, rebamipide liquid significantly reduced the expressions of IL-6, IL-1β, TNF-α, Cxcl1, Ccl2 and Cox2 in a dose-dependent manner (p < 0.01) in ulceration phase of the rat model. Conclusions: NF-κB signaling and/or TNF-α-mediated inflammatory responses may contribute to the initial development of radiation-induced oral mucositis. Rebamipide liquid has an ability to suppress these pro-inflammatory signaling which may lead the preventive effect on radiation-induced mucositis.
A comparison of hospitalized and nonhospitalized borderline patients
Authors: H W Koenigsberg
Journal: American Journal of Psychiatry (1982)

The author compared 14 hospitalized borderline patients with 24 nonhospitalized patients given the same diagnosis. Twenty-nine clinical features of borderline patients were examined using the semistructured Diagnostic Interview for Borderlines. Although a few specific differences emerged in such areas as drug abuse, self-mutilation, and psychotherapy experience, both hospitalized and nonhospitalized patients manifested characteristic borderline traits of disturbed impulse-action patterns, psychotic experiences, poor regulation of affect, and disturbed interpersonal relationships. These findings are consistent with those of other studies and suggest that hospitalized and nonhospitalized borderline patients represent the same diagnostic entity.
Chiari’s Syndrome
Authors: Harold L. Hirsh, Benjamin Manchester
Journal: New England Journal of Medicine (1946)

CHIARI'S syndrome is a rarely observed clinical entity and is seldom diagnosed during life. It was first adequately described by Budd1 in 1846 but bears the name of Chiari,2 who in 1899 reported more completely 3 cases seen in his clinic and collected 7 additional cases. As first described the syndrome was a manifestation of a primary obliterating endophlebitis of the hepatic veins. Other related pathologic processes have subsequently been shown to produce this disease entity.The symptom complex manifested by this syndrome is not generally known. A search of the literature reveals only about 70 reported cases. Out of . . .
Is Programmed Stimulation of Value in Predicting the Long-Term Success of Antiarrhythmic Therapy for Ventricular Tachycardias?
Authors: Soo G. Kim, Steven W. Seiden, Samuel D. Felder, Lawrence E. Waspe, John D. Fisher
Journal: New England Journal of Medicine (1986)

We studied the value of programmed stimulation in assessing the efficacy of antiarrhythmic agents in 52 patients with sustained ventricular tachycardia. All patients in this nonrandomized study had ventricular tachycardia inducible by programmed stimulation and also had frequent ventricular premature complexes (greater than or equal to 30 per hour) on Holter-monitor recordings before therapy. The efficacy of antiarrhythmic agents was assessed by both programmed stimulation and Holter recordings during serial drug testing. A regimen was deemed effective according to the programmed-stimulation criteria in 25 patients (Group 1). Twenty-seven patients in whom tachycardia could still be induced during programmed stimulation despite extensive drug trials were discharged on a regimen that caused a marked reduction of ventricular premature complexes according to Holter monitoring (Group 2). In 23 patients no effective drug regimen was identified by either set of efficacy criteria, and these patients were excluded from the present analysis. Follow-up lasted 18.6 +/- 13.9 months. Rates of arrhythmia-free survival at 12 and 24 months were 88 percent and 72 percent, respectively, in Group 1 and 84 percent and 75 percent in Group 2 (P = 0.637). We conclude that demonstration of antiarrhythmic efficacy by programmed stimulation predicts a good clinical outcome, that inefficacy as shown by the programmed-stimulation protocol used in this study may not preclude a good outcome if there is a marked reduction of spontaneous ventricular premature complexes on Holter monitoring, and that randomized trials should be conducted to validate the results of this observational study.
Treatment of Essential Hypertension with a New Vasodilator in Combination with Beta-Adrenergic Blockade
Authors: Edward Gilmore, John Weil, Charles Chidsey
Journal: New England Journal of Medicine (1970)

A new piperidino-pyrimidine vasodilator (PDP) when used in the treatment of 11 hypertensive patients, lowered blood pressure from 188/124 to 159/100 over six to seven days. blood-pressure responses to standing, cold-pressor test and Valsalva maneuver persisted, and postural symptoms did not occur despite marked reduction of blood pressure. However, the antihypertensive action was associated with reflexly induced increases in heart rate, cardiac index and norepinephrine excretion and evidence of myocardial ischemia in some patients. Selective beta-adrenergic blockade with propranolol prevented this augmentation of cardiac activity and further decreased blood pressure. Although glomerular filtration rate and renal plasma flow were unchanged, sodium retention occurred in all patients. Such retention appeared to be readily controllable with oral diuretics in the one patient to whom it was given. Thus, PDP combined with propranolol results in highly effective lowering of blood pressure in hypertensive patients without attendant postural symptoms, and may provide an important new approach to antihypertensive therapy.
P147 Evidence of modifiable prescription factors in primary asthma care
Authors: C Lewis, E Humphreys, V Carter, A Chisholm, D Price, S Walker
Journal: Thorax (2015)

<h3>Background</h3> In 2014, the Royal College of Physicians published the National Review of Asthma Deaths. This confidential enquiry into 195 confirmed asthma deaths in the UK highlighted that two thirds of these deaths were associated with potentially modifiable prescription factors including excessive short-acting beta agonist (SABA) use without review and prescription of long acting beta agonists (LABA) without inhaled corticosteroids (ICS), the latter of which have been associated with higher mortality.<sup>1</sup> <h3>Aim</h3> The aim of this project was to determine how widespread these two modifiable prescription factors are in the treatment of asthma in UK general practice. <h3>Methods</h3> Primary Care data were obtained from the Optimum Patient Care Research Database (OPCRD). Extraction criteria included patients with a current diagnosis of asthma, at least two years of continuous medical records and at least one asthma prescription in the preceding 12 months. Those who: had a comorbid diagnosis of COPD, had received no treatment for the past 12 months and children &lt;4 years of age were excluded. Asthma prescription data for the previous 12 months were extracted, and patients who had been prescribed LABAs with no ICS, or who had been prescribed ≥12 SABA inhalers without an asthma review (as coded by QOF) were identified. <h3>Results</h3> 94,955 asthma patients met the inclusion criteria, of which 12661 (13%) were children. LABAs with no ICS had been prescribed to 402 patients (0.4%). A total of 5032 patients (5.3%) had been prescribed ≥ 12 SABA inhalers, ranging from 13–136 inhalers of which 1965 (39%) had not had an asthma review. Among these, 117 were children, 0.92% of the total. <h3>Conclusion</h3> These data, covering a large GP population, suggest evidence of non-guideline recommended prescribing which might contribute to increased risk to asthma patients. Prescribers should consider implementing system alerts to identify and review such prescribing behaviours. <h3>Reference</h3> 1 Lee C, Corren J. Budesonide/formoterol in the treatment of asthma. <i>Expert Rev Respir Med</i> 2008;<b>2</b>:551–64
Hematogenous Candida Endophthalmitis — A Complication of Candidemia
Authors: Louis S. Fishman, John R. Griffin, Francisco L. Sapico, Robert Hecht
Journal: New England Journal of Medicine (1972)

Six patients with candidemia and candida endophthalmitis had received systemic antibiotics and had prolonged indwelling intravenous catheters. Symptoms, which began three to 15 days after the positive blood cultures for candida, included blurring of vision, spots before the eye and pain in or around the eye. In two cases lesions were found in the absence of symptoms. Frank intravitreous extension occurred in three, and an anterior uveitis in the other three patients. The administration of amphotericin B (one patient also received 5-fluorocytosine) resulted in healing of the lesions and improvement in visual acuity in five cases. The management of patients with candidemia should include careful attention to ocular complaints and repeated ophthalmoscopic examinations. On detection of the typical lesions, therapy with systemic amphotericin B is indicated.
Neuraminidase-Augmented Anticarcinoembryonic Antigen (CEA)-Complement Lysis of Human Colon Tumor Cells: Lack of Correlation With Anti-CEA-Mediated K-Cell Lysis and Iodine-125 Binding2
Authors: Wayne A. F. Tompkins, John D. Schmale, Richard Mock, Nadine T. Tick, Ted Lock, Neil Sidell, Jerry L. Palmer
Journal: JNCI Journal of the National Cancer Institute (1979)

Journal Article Neuraminidase-Augmented Anticarcinoembryonic Antigen (CEA)-Complement Lysis of Human Colon Tumor Cells: Lack of Correlation With Anti-CEA-Mediated K-Cell Lysis and Iodine-125 Binding Get access Wayne A. F. Tompkins, Wayne A. F. Tompkins 6 3Center for Zoonoses and Comparative Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Ill. 61801. 4School of Basic Medical Sciences, University of Illinois. 5Radiation Oncology Training Program, College of Veterinary Medicine, University of Illinois. 6Address reprint requests to Dr. Tompkins at the Center for Zoonoses and Comparative Medicine. Search for other works by this author on: Oxford Academic PubMed Google Scholar John D. Schmale, John D. Schmale 4School of Basic Medical Sciences, University of Illinois. Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard Mock, Richard Mock 3Center for Zoonoses and Comparative Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Ill. 61801. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nadine T. Tick, Nadine T. Tick 3Center for Zoonoses and Comparative Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Ill. 61801. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ted Lock, Ted Lock 3Center for Zoonoses and Comparative Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Ill. 61801. Search for other works by this author on: Oxford Academic PubMed Google Scholar Neil Sidell, Neil Sidell 5Radiation Oncology Training Program, College of Veterinary Medicine, University of Illinois. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jerry L. Palmer Jerry L. Palmer 3Center for Zoonoses and Comparative Medicine, College of Veterinary Medicine, University of Illinois, Urbana, Ill. 61801. 7We thank Mr. Kevin Spencer, Ms. Lisa Critchlow, and Ms. Candace Hart for excellent technical assistance; Mr. Walter Crackel for his expert assistance with the radio-iodination procedures; and Ms. Grace Connelly, Dr. Ben Williams, Dr. F. Toledo, and the staff of Mercy Hospital, Champaign, Ill., for clinical assistance. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 62, Issue 3, March 1979, Pages 503–511, https://doi.org/10.1093/jnci/62.3.503 Published: 01 March 1979 Article history Received: 15 June 1978 Accepted: 13 September 1978 Published: 01 March 1979
Synchronization of Augmented Luteinizing Hormone Secretion with Sleep during Puberty
Authors: Robert Boyar, Jordan Finkelstein, Howard Roffwarg, Sheldon Kapen, Elliot Weitzman, Leon Hellman
Journal: New England Journal of Medicine (1972)

Abstract Luteinizing hormone (LH) was measured in plasma every 20 minutes for 24 hours in 14 children and adolescents in different stages of sexual maturation and in five adult men. Polygraphic monitoring of nocturnal sleep was carried out simultaneously to identify sleep onset, wakefulness and sleep stages precisely. Prepubertal children and adult men showed no consistent significant difference between mean LH concentrations with subjects asleep and awake. In all pubertal subjects, an increase in LH secretion was associated with sleep that resulted in significantly higher mean LH concentrations than with the subject awake. By experimental delay in sleep onset, synchronization of this LH secretory program with actual sleep was clearly demonstrated. The number of LH secretory episodes during night or day sleep corresponded to the number of sleep cycles of rapid and nonrapid eye movements. This finding of a sleep-associated increase in LH secretory activity provides a biologic index for the identification...
Acute Kidney Injury With Buffered Crystalloids vs Saline Among ICU Patients
Authors: Alexander H. Flannery, Angel O. Coz-Yataco
Journal: JAMA (2016)

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