tbuckley/cabot-search huggingface dataset:
Large Thigh and Buttock Muscle Metastases as the Initial Manifestation of Follicular Thyroid Cancer
Authors: Yan-Li Xue, Hong-Jun Song, Zhong-Ling Qiu, Quan-Yong Luo
Journal: Clinical Nuclear Medicine (2013)

Follicular thyroid carcinoma (FTC) is the second most common thyroid malignancy after papillary thyroid carcinoma (PTC). It has a greater tendency than PTC to metastasize to distant organs such as the lung and bone. FTC metastasis to skeletal muscle is extremely rare. Here, we report a 65-year-old woman with large thigh and buttock muscle metastases as the first manifestation of FTC.
Active Retrobulbar Inflammation in Graves’ Ophthalmopathy Visualized by Tc-99m DTPA SPECT
Authors: László Galuska, József Varga, Zsolt Szucs Farkas, Ildikó Garai, Judit Boda, Jeno Szabo, Andras Leovey, Endre V. Nagy
Journal: Clinical Nuclear Medicine (2003)

GALUSKA, LÁSZLÓ M.D., PH.D.*; VARGA, JÓZSEF PH.D.*; SZUCS FARKAS, ZSOLT M.D.†; GARAI, ILDIKÓ M.D.*; BODA, JUDIT M.D.‡; SZABO, JENO M.D.‡; LEOVEY, ANDRAS M.D., D.SC.‡; NAGY, ENDRE V. M.D., PH.D.‡ Author Information
On both sides of the table
Authors: D. Humphriss
Journal: BMJ (1997)

God and the trust board willing, I need never do another job interview. In the NHS candidates practise their interview technique at the interviews where they hope they never stood a chance. The peripatetic candidate soon realises that interviewers are also engaged in on the job training but with less opportunity for practice. Institutions can no longer expect a constant stream of acceptable cannon fodder and it must be in their interests to organise interviews which show candidates and institutions to the best advantage. These experiences are my own, but are not unusual enough to justify complacency. Changes are needed.

A good start …
Advocacy Groups Hold Capitol Hill "Teach-In"
Authors: B. Duane
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Advocacy Groups Hold Capitol Hill “Teach-In” Get access Betsy Duane Betsy Duane Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 23, 4 December 1991, Page 1719, https://doi.org/10.1093/jnci/83.23.1719-a Published: 04 December 1991
Detection of mcr-1 colistin resistance gene in polyclonal Escherichia coli isolates in Barcelona, Spain, 2012 to 2015
Authors: Núria Prim, Alba Rivera, Judith Rodríguez-Navarro, Montserrat Español, Miquel Turbau, Pere Coll, Beatriz Mirelis
Journal: Eurosurveillance (2016)

Colistin resistance was detected in 53 of 10,011 Escherichia coli (0.5%) by prospective phenotypic testing of consecutive clinical isolates in a single hospital in Barcelona, Spain (2012–15). The mcr-1 gene was retrospectively identified by PCR and sequencing in 15 of 50 available isolates. Each isolate had a unique PFGE pattern except for two. This clonal diversity supports the hypothesis of horizontal dissemination of the mcr-1 gene in the local study population.
BT-06 * PLK1 AS A POTENTIAL THERAPEUTIC TARGET FOR DIPG
Authors: V. Amani, S. Venkataraman, E. Prince, D. Birks, I. Balakrishnan, A. Donson, A. Griesinger, P. Harris, N. Foreman, R. Vibhakar
Journal: Neuro-Oncology (2015)

Diffuse intrinsic pontine gliomas (DIPGs) are highly aggressive, universally fatal, childhood tumors that arise in the brainstem.DIPGs have no effective treatment, and their location and diffuse nature render them inoperable.
FRI0048 Prevalence of Tuberculosis in Early Arthritis and Early Spondyloarthritis Increased in Comparison to the General Population - Results from the ESPOIR and DESIR Cohorts: Table 1.
Authors: A.M. Gherghe, M. Dougados, B. Combe, R. Landewé, C. Mihai, F. Berenbaum, X. Mariette, R. Wolterbeek, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) have an increased risk of developing tuberculosis (TB), which is possibly related to the disease itself, as well as to the treatment with immunosuppressive drugs. Several studies investigated this risk; however, they usually include patients with established disease and patients who received long-term treatment. <h3>Objectives</h3> To investigate the association between history of TB and early RA (ERA) and early axial SpA (ESpA) in 2 French cohorts, ESPOIR (1) and DESIR (2), at onset of the disease. <h3>Methods</h3> Baseline data of 689 ESPOIR patients (age 48.2±12.1 years, symptom duration 14.2±14.5 weeks) and 645 DESIR patients (age 32.8±8.4 years, axial symptom duration 79.0±45.7 weeks) were analyzed. The frequency of history of TB was determined in each cohort. The prevalence (95% confidence intervals (95% CI)) of history of TB was compared to the age and gender adjusted prevalence in the French general population (data gathered from the statistic reports of the French National Health Insurance Fund for the Employees, including almost 90% of the total French population). <h3>Results</h3> 4.6% of ERA patients and 0.9% of ESpA had a history of TB. The prevalence (95% CI) of TB history was significantly higher in ESPOIR and DESIR than in the general population (4.7% (3.3%&gt;6.6%) and 1.0% (0.4%&gt;2.3%), vs. 0.02%) after adjustment for age and gender. The increase was more accentuated in women for both cohorts. <h3>Conclusions</h3> We found an increased frequency of history of TB in ERA and ESpA even after short symptom duration, and before treatment start. These data are based on self-declaration of patients and should be checked, but are in line with the increased frequency of positivity of Quantiferon in the RA population. These results should prompt rheumatologists to check for tuberculosis already early in disease. <h3>References</h3> Combe B et al. Joint Bone Spine. 2007 Oct;74(5):440-5. Dougados M et al. Joint Bone Spine. 2011 Dec;78(6):598-603. <h3>Acknowledgements</h3> AMG was supported by a EULAR scientific training bursary for 6 months. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1970
AB1140 Diagnostic classification and therapeutic interest of joint ultrasonography in idiopathic juvenile arthritis: Survey on 27 children
Authors: M. Halbwachs, G. Durand, E. Solau-Gervais
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> For several years, some adult studies have already shown the interest of joint evaluation by ultrasound in diagnostic and therapeutic adjustment in inflammatory rheumatic diseases. In juvenile idiopathic arthritis (JIA), several authors have demonstrated that ultrasonography (US) is more sensitive to detect synovitis than clinical examination <h3>Objectives</h3> This study aims to determine joint ultrasonography's interest in diagnostic classification and therapeutic management of JIA children. <h3>Methods</h3> This is a unicentric, open cross-sectional study, led on twenty-sevenoutpatients with JIA between March 2010 and January 2012. Ultrasound evaluations were always carried out by the same rheumatologist, trained in joint US. Wrists, hands and feet were systematically analysed and also any painful joint. US was either carried out before beginning disease modifying anti-rheumatic drugs(DMARDs) or corticosteroids therapy, or after their setting-up, in the follow-up. The ultrasound scanner is an Esaote Mylab 60. <h3>Results</h3> Among the twenty-seven children followed, US have been carried out in thirteen of them. 53,8% of the thirteen children are oligoarticular JIA and 46,2% are polyarticular onset. Between March 2010 and January 2012, thirty US have been realized on thirteen children. Subclinical synovitis was brought to light in 80% of cases. The average number of ultrasonography's synovitis was 5,33 against 1,3 clinical synovitis. On the 27 JIA, 2 children had a change in their classification from oligoarticular to extend oligoarticular disease. Seven children benefit of an ultrasonography before DMARD or corticosteroid therapy establishment. with an average number of ultrasonography's synovitis of 8,1 against 2,1 clinical synovitis. Twenty US has been carried out at eleven children treated by DMARD or corticosteroid. The US led on therapeutic intensification in 45% of cases, in face of subclinical synovitis. This setting up is a dose increase adjustment in 55,6% and a change of therapy in 44,4% of cases. <h3>Conclusions</h3> This study confirms interest of achievement joint US in detection of subclinical synovitis and suggests its interest in therapeutic management of JIA children. <h3>References</h3> Magni-Manzoni S et al. Arthritis Rheum. 2009;61:1497–1504 Breton S et al. Semin Arthritis Rheum. 2011;41(2):272-8 <h3>Disclosure of Interest</h3> M. Halbwachs: None Declared, G. Durand: None Declared, E. Solau-Gervais Grant/Research support from: ROCHE
The Role of 99mTc-Tetrofosmin Brain SPECT in Intracranial Meningiomas
Authors: George A. Alexiou, Spyridon Voulgaris, Spyridon Tsiouris, Andreas D. Fotopoulos, Athanasios P. Kyritsis
Journal: Clinical Nuclear Medicine (2012)

Alexiou, George A. MD, PhD1; Voulgaris, Spyridon MD, PhD1; Tsiouris, Spyridon MD2; Fotopoulos, Andreas D. MD, PhD2; Kyritsis, Athanasios P. MD, PhD3 Author Information
Abstract 5429: Robust in vitro cancer metabolism in non-tumorigenic microglial cells.
Authors: Roberto Flores, Kenjiro Kami, Thomas Seyfried
Journal: Cancer Research (2013)

Abstract It is well documented that energy metabolism differs between cancerous tissue and normal tissue for a large variety of human and animal tumors. The murine J2 retrovirus contributes to oncogenesis in macrophage cells. The BV-2 microglia cells were immortalized using the v-raf/v-myc carrying J2 retrovirus. These cells, however, do not form tumors when grown in vivo in the natural C57BL/6 host. Consistent with v-raf/v-myc expression, the in vitro metabolic and proliferation rate of the BV-2 cells greatly exceeded that of the tumorigenic and metastatic VM-M3 microglia cells when grown in DMEM containing 25 mM glucose. When controlling for proliferation and ATP production, the BV-2 cells produced more lactate than did the VM-M3 cells under aerobic conditions, thus demonstrating a robust Warburg effect in the BV-2 cells. The Warburg effect is associated with HIF stabilization under aerobic conditions. Mutations in the IDH1 gene produce 2-hydroxyglutarate (2HG), a recognized “onco-metabolite” that also contributes to HIF stabilization under aerobic conditions. Mass spectrometry analysis showed that the non-tumorigenic BV-2 cells made 2-HG only under anoxic conditions. 2-HG was not detected under anoxia or normoxia in VM-M3LM cells, a less malignant clonal variant of VM-M3. It appears that the BV-2 cells have a more robust cancer metabolism than either the high malignant VM-M3 cells or the low malignant VM-M3LM cells. The VM-M3LM cells consumed more oxygen and produced less lactate per ATP than did either the BV-2 cells or the VM-M3 cells, thus displaying a reduced Warburg effect. In other words, the Warburg effect was greatest in the non-tumorigenic BV-2 cells, was lowest in the low malignant VM-M3LM cells, but was intermediate in the high malignant VM-M3 cells. The results suggest that over expression of the v-raf/v-myc oncogenes, production of the IDH1 onco-metabolite, and a robust Warburg effect are not sufficient to drive tumorigenesis in the BV-2 cells. Supported in part from Boston College Res. Expense Fund. Citation Format: Roberto Flores, Kenjiro Kami, Thomas Seyfried. Robust in vitro cancer metabolism in non-tumorigenic microglial cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5429. doi:10.1158/1538-7445.AM2013-5429 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
Case 43-1993
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, John W. Henson, Mary Jane Ferraro
Journal: New England Journal of Medicine (1993)

Presentation of CaseA 71-year-old right-handed woman was admitted to the hospital because of a question of a brain tumor.The patient had been in stable health until four months earlier, when she became aware of difficulty in concentrating. Three weeks before entry she began to have midline frontal headaches accompanied by a sensation of local “pressure.” Soon thereafter she observed intermittent diplopia during which objects appeared to be skewed. About one week later she had difficulty in reading and writing a letter and affixed a stamp to the upper left corner of the envelope and was then unable to . . .
FRI0042 Baff signaling is abnormally regulated through JAK pathways in peripheral monocytes in patients with primary sjÖgren’s syndrome
Authors: K. Yoshimoto, M. Tanaka, M. Kojima, H. Ogata, K. Suzuki, H. Kameda, T. Abe, T. Takeuchi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> B cell activating factor belonging to the TNF superfamily (BAFF) regulates proliferation, differentiation and survival of B cells and plays a pivotal role in the pathogenesis of autoimmune diseases such as primary Sjögren's syndrome (pSS). Several lines of evidence have suggested that elevated production of BAFF is involved in the development of pSS. In our previous study, we revealed that IFN-gamma remarkably induced the production of BAFF and IL-6 by pSS monocytes and that BAFF induced robust production of IL-6 by these cells. These data strongly suggest that the production of IL-6 in monocytes is induced through a signal transduction pathway triggered by BAFF. On the other hand, IFN-gamma and BAFF provoked only modest responses in normal monocytes. Therefore, elucidation of the regulatory mechanism which underlies the aberrant production of IL-6 by pSS monocytes is important not only to understand the mechanism of pathogenesis of pSS, but also to explore therapeutic possibilities to treat the disease. <h3>Objectives</h3> We investigated the expression level of a BAFF receptor (BAFF-R) in pSS monocytes and possible abnormalities of BAFF signaling pathways in these cells. <h3>Methods</h3> Peripheral monocytes from pSS patients and age-matched normal individualswere stimulated in vitro with soluble BAFF (sBAFF) in the presence or absence of inhibitors against JAK2 and JAK3. The expression level of BAFF-R in the cells was analyzed by FACS and quantitative PCR. ELISA was employed to measure the production of IL-6 by the cells. The expression levels of the JAK2 and JAK3 were analyzed by quantitative PCR. <h3>Results</h3> Quantitative PCR analysis revealed that the expression level of BAFF-R was significantly elevated in SS monocytes (2.1-fold) compared to normal monocytes. In accordance with these data, FACS analysis indicated that approximately 60% of pSS monocytes were BAFF-R-positive while only about 25% of normal monocytes expressed BAFF-R. On the other hand, there were no significant differences between pSS patients and normal individuals in the population of BAFF-R-positive B and T cells. Moreover, the expression level of BAFF-R was positively correlated with the production of IL-6 among monocytes prepared from pSS patients enrolled in this study. We found that a JAK3 inhibitor (WHI-P131) showed strong suppressive effect on the induction of IL-6 in a dose dependent manner. Interestingly, stimulation of pSS monocytes with sBAFF strongly induced the expression of JAK3 while normal monocytes did not significantly respond to the stimulation. <h3>Conclusions</h3> BAFF activates the expression of the IL-6 through a JAK pathway in monocytes and that the expression of BAFF-R and JAK3 is abnormally regulated in pSS monocytes. <h3>Disclosure of Interest</h3> None Declared
DIABETES MELLITUS AND CARDIOVASCULAR RISK IN PATIENTS WITH CHRONIC CORONARY HEART DISEASE
Authors: Peter R. Sinnaeve, Emil Hagstrom, Paul Armstrong, Andrzej Budaj, Moses Elisaf, Christopher Granger, Claes Held, Wolfgang Koenig, Terje Pedersen, Amanda Stebbins, Philippe Steg, Ralph Stewart, Tamio Teramoto, Hung-Fat Tse, Lars Wallentin, David Watson, Harvey White
Journal: Journal of the American College of Cardiology (2016)
PD03-02: Prognostic and Predictive Predictors for Triple Negative Breast Cancer.
Authors: T Karn, L Pusztai, E Ruckhäberle, C Liedtke, M Schmidt, V Müller, R Gätje, L Hanker, A Ahr, U Holtrich, A Rody, M Kaufmann
Journal: Cancer Research (2011)

Abstract Background: Both the prognosis and the therapeutic options in triple negative breast cancer (TNBC) are rather limited. Current prognostic gene expression profiles for breast cancer mainly reflect proliferation status and are most useful in ER-positive cancers. The identification of prognostic gene signatures from TNBC cohorts in previous studies was hindered due to relatively small sample sizes. Materials and Methods: All currently available TNBC gene expression datasets generated on Affymetrix U133 gene chips were assembled. To minimize inter-laboratory variation we analyzed only highly comparable arrays and data set-biased genes were filtered. Supervised analysis was applied to identify a prognostic signature from a finding cohort of 394 TNBC and validation was performed in an independent cohort of 261 TNBC. The genes from the prognostic predictor were analyzed for their correlation to known molecular phenotypes among TNBC. Results: Two supervised prognostic signatures consisting of 264 and 26 probesets, respectively, were obtained when applying different cutoffs for false discovery rates of 25% and &amp;lt; 3.5% in the finding cohort. In multivariate analysis in the independent validation cohort hazard ratios of 4.03 (95% CI 1.71−9.48; P=0.001) and 4.08 (95% CI 1.79−9.28; P=0.001), respectively, were obtained for the two signatures. When compared to 16 metagenes for previously described molecular phenotypes in TNBC the prognostic signatures displayed highest correlation to metagenes for IL-8/inflammation, VEGF/angiogenesis, and Histones. A subset of genes in the 264-probeset signature was inversely associated with a poor prognosis (29/264=11.0%). Most of these “good prognosis” genes are correlated with immune cell metagenes (21/29=72.4%). In contrast both identified supervised prognostic signatures did not correlate to previously published prognostic signatures (recurrence score, genomic grade index, Amsterdam signature, wound response signature, 7-gene immune response module, stroma derived prognostic predictor, and a medullary like signature). Regarding the response of TNBC to neoadjuvant chemotherapy the predictive value of the B-cell metagene was superior to the 264- and 26-probeset signatures. However combination of the B-cell metagene and the signatures increased the AUC in ROC-analysis from 0.606 to 0.656. Conclusions: The use datasets consisting only of TNBC allows identification supervised prognostic signatures for TNBC which are unrelated to previously known prognostic signatures. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr PD03-02.
Abstract 1801: ERK-mediated regulation of NFAT3 enhances CXCR4 expression in HeyA8 ovarian cell line.
Authors: Keven Huang, Christine Kiefer, Adeela Kamal
Journal: Cancer Research (2013)

Abstract The G-protein coupled chemokine (C-X-C motif) receptor CXCR4 is linked to cancer, HIV, and WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome. While CXCR4 is widely studied and characterized extensively to be over-expressed in multiple human tumor tissues, we have seen poor surface CXCR4 expression in many solid tumor cell lines in vitro. To better understand how CXCR4 is regulated, cells grown under 3-D spheroid conditions were compared to normal adherent culturing conditions. When cultured as 3D spheroids, HeyA8 cells showed a dramatic increase in surface CXCR4 protein levels as well as mRNA transcripts. Furthermore, HeyA8 3D spheroids showed a decrease in pERK levels when compared to adherent cells. Using an inhibitor of the MEK-ERK pathway, the treatment of adherent HeyA8 cells with U0126 resulted in a significant increase in surface CXCR4 expression similar to 3D spheroids. Additional investigation using PCR array showed a wide range of transcription factors being up-regulated but notably a &amp;gt; 20 fold increase in NFAT3 transcription factor. Using a calcineurin inhibitor, cyclosporin A diminished the U0126 treated up-regulation of CXCR4 surface expression. Finally, Chromatin Immunoprecipitation analysis showed direct binding of NFAT3 on the CXCR4 promoter to increase CXCR4 expression in HeyA8 ovarian cell line. Taken together, our results suggest that phospho-ERK levels regulate CXCR4 expression through the NFAT3 signaling pathway. Citation Format: Keven Huang, Christine Kiefer, Adeela Kamal. ERK-mediated regulation of NFAT3 enhances CXCR4 expression in HeyA8 ovarian cell line. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1801. doi:10.1158/1538-7445.AM2013-1801 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
The Harvard Medical Unit at the Boston City Hospital — A Perspective
Authors: Maxwell Finland
Journal: New England Journal of Medicine (1964)

HARVARD Medical School has been intimately associated with the Boston City Hospital since its very inception. The original staff of 6 visiting physicians at the time the Hospital was opened in 1864 consisted of graduates of Harvard Medical School1; the first house staff was recruited entirely from among its students,2 and the teaching of undergraduate medical students from Harvard began in the same year.3 In 1914 the Fourth Medical Service was authorized, and it was designated for Harvard teaching during the following year. The Thorndike Memorial Laboratory was occupied in 1923, and the Thorndike Ward received its first patients . . .