tbuckley/cabot-search huggingface dataset:
THU0463 Protracted Febrile Myalgia of Familial Mediterranean Fever can be Reliably Detected by Magnetic Resonance Imaging: A Comprehensive Analysis of 20 Cases
Authors: I. Simsek, S. Yilmaz, H. T. Sanal, M. Cinar, H. Erdem, S. Pay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Protracted febrile myalgia (PFM) is a rare and least well recognized manifestation of familial Mediterranen fever (FMF), characterized by prolonged excruciating muscle pain, tenderness, fever, and elevated levels of acute phase reactants. While the diagnosis of PFM in the setting of previously diagnosed FMF is mostly clinical, diagnosis of PFM when it is the sole manifestation of FMF might be challenging. <h3>Objectives</h3> To analyse clinical, laboratory, genetic, electrophysiologic, histopathologic, and magnetic resonance imaging (MRI) findings in a series of patients who presented to our department with myalgia and diagnosed as having PFM secondary to FMF. <h3>Methods</h3> We describe a retrospective cohort PFM patients seen at our department between 2009 and 2012. Clinical, laboratory, and imaging data were obtained by medical record review. <h3>Results</h3> Study group consisted of 20 (19 male, mean age = 20 years, SD = 3.2) patients. Four (20%) of the patients had a previous diagnosis of FMF, while PFM occurred as the presenting symptom of FMF in 40%. Mean age of disease onset was 17 ± 2.6 years, characterized by severe muscle pain in lower extremities in all patients and affecting single extremity in 90% of the cases. M694V allelic involvement was noted in 80% of the patients. Muscle enzymes were in normal range in all patients, and EMGs were normal in all studied patients (n=13), but one. None of the patients in whom muscle biopsy was available (n=8) showed features compatible with myositis. All of the patients underwent MRI of the symptomatic extremity and showed different degrees of involvement on the MR images of the affected extremities. On MR images, the muscle involvement was either patchy or diffuse, displayed with the high signal intensity on fluid sensitive and gadolinium-enhanced fat saturated T1-weighted images. Extension of the inflammation around individual muscles and muscle groups (myofascial distribution) was observed, as well as subcutaneous tissue edema. <h3>Conclusions</h3> This series of patients with PFM, to our knowledge, is the largest one reported in the literature. PFM can be the initial manifestation of FMF in some of the patients. Due to the lack of any specific abnormalities other than elevated acute phase response, diagnosis of such cases possess some difficulties. With the appropriate clinical history, detection of MRI findings compatible with myositis in the absence of other features suggestive of myositis (muscle enzymes, EMG, etc.) can help make or confirm the diagnosis of PFM, particularly in areas where the FMF is prevalent. <h3>Disclosure of Interest</h3> None Declared
SAT0477 Prevalence of Generalized Joint Hypermobility and Fibromyalgia Syndrome in the Children Population of Trabzon; Turkish Study
Authors: M. Karkucak, O. F. Barcak, E. Capkın, B. Dilber, G. Karagüzel
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Generalized Joint hypermobility (GJH) and fibromyalgia syndrome (FMS) are two clinical conditions that may cause common musculoskeletal pain during childhood. <h3>Objectives</h3> Our study aimed to evaluate the frequency of juvenile FMS and GJH in children aged 11-18 years in the province, Trabzon as well as the correlation between these two conditions. <h3>Methods</h3> This cross-sectional study was performed with 437 students aged 11-18 years who receive education in the province, Trabzon. Questionnaire forms were filled in, and each student was examined. The children, who reported to have any disease, were excluded from the study. GJH was diagnosed according to criteria of Beighton diagnosis. The presence of FMS was determined according to the 1990 American College of Rheumatology (ACR) classification criteria <h3>Results</h3> A total of 437 students, 209 of whom are girls (52.2%) and 228 (47.8%) of whom are boys, participated in the study. The mean age was 14.3±1.7 years for girls and 14.7±1.79 years for boys. The frequency of GJH was found to be 9.1% and the frequency of FMS was found to be 5.9% for students who were included in the study. While significant difference was observed among the female and male participants in terms of the frequency of GJH (p=0.023), no such difference was detected among the genders in FMS (p=0.065). A statistically significant and highly negative correlation was found between age and Beighton score (r=-0.187, p&lt;0.001). A statistically significant and highly negative correlation was found between Body Mass Index (BMI) and Beighton score (r=-0.097, p&lt;0.05). There was a correlation between success level at school and tender point. Both FMS and GJH were detected in one patient. No correlation was detected between Beighton score and tender point. <h3>Conclusions</h3> As with children in other countries, GJH and FMS are non-rare clinical conditions in Turkey as well. They seem to be cases independent of each other. The clinicians must also consider GJH and FMS in differential diagnosis especially in children who present with complaints of musculoskeletal system pain. <h3>References</h3> none <h3>Disclosure of Interest</h3> None Declared
3-D Display of Tc-99m DMSA SPECT in Crossed Fused Renal Ectopia
Authors: CHRIS J. HARVEY, JOHN R. BUSCOMBE, ANDREW J.W. HILSON
Journal: Clinical Nuclear Medicine (1998)

A 24-year-old pregnant woman had recurrent urinary tract infections. An ultrasound examination showed a right kidney of normal site and size with minimal dilatation of the pelvicalyceal system, but no left kidney was identified. A SPECT Tc-99m DMSA scan was performed postpartum and demonstrated crossed fused renal ectopia confirmed by intravenous urogram.
Stimulation of Muscle Protein Degradation and Prostaglandin E<sub>2</sub>Release by Leukocytic Pyrogen (Interleukin-1)
Authors: Vickie Baracos, H. Peter Rodemann, Charles A. Dinarello, Alfred L. Goldberg
Journal: New England Journal of Medicine (1983)

To clarify the mechanisms underlying the loss of body protein during fever and sepsis, we incubated rat muscles with highly purified human leukocytic pyrogen. This polypeptide, which appears identical to interleukin-1, is released by leukocytes and signals the onset of fever in the hypothalamus. In muscles incubated at 37°C, leukocytic pyrogen stimulated net protein degradation by 62 to 118 per cent (P<0.001 ). Proteolysis increased, but rates of muscle-protein synthesis did not change. The pyrogen also dramatically stimulated muscle synthesis of prostaglandin E2, which promotes protein breakdown in this tissue. Addition of indomethacin with leukocytic pyrogen prevented prostaglandin E2 synthesis and abolished the increase in proteolysis. The acceleration of protein breakdown induced by pyrogen was also blocked by Ep-475, an inhibitor of lysosomal thiol proteases. When muscles were incubated at 39°C to mimic fever, protein breakdown increased, but addition of leukocytic pyrogen caused a further marked increase in proteolysis and prostaglandin E2 production. Thus, human leukocytic pyrogen can act on skeletal muscle to stimulate intralysosomal proteolysis by increasing the production of prostaglandin E2. These findings suggest that cyclooxygenase inhibitors may be useful in the treatment of negative nitrogen balance in fever. In addition, the release of prostaglandin E2 induced by leukocytic pyrogen may account for the myalgia that accompanies fever. (N Engl J Med. 1983; 308:553–8.)
Cardiovascular and Renal Complications of Cushing's Syndrome
Authors: Donald A. Scholz, Randall G. Sprague, James W. Kernohan
Journal: New England Journal of Medicine (1957)

CARDIOVASCULAR and renal changes are frequently important features of Cushing's syndrome. Of the 12 cases reported by Cushing1 in 1932, hypertension occurred in 9, and cardiac hypertrophy in 4. Friedberg2 has stressed the fact that the most important finding so far as the vascular system is concerned is hypertension, which may be severe and associated with cardiac enlargement, cerebral hemorrhage and renal insufficiency. In a review of 67 cases of Cushing's syndrome compiled from the literature, Eisenhardt and Thompson3 found hypertension in 57 cases, and Cope and Raker4 described significant hypertension in approximately half of 46 cases and mild or . . .
Role of adjuvant HPV testing and continued Pap smear screening in women over age 6
Authors: S. Waheed, T. A. Linthacum
Journal: Journal of Clinical Oncology (2008)

1531 Background: A rural comprehensive cancer screening program at Audrain Medical Center in Mexico, Missouri, provides early detection, education, and cancer prevention for women primarily over the age of 40 and men over the age of 50. The cancer screening examination for women includes a head to toe skin examination, clinical breast exam, screening mammography, liquid-based Pap test, and pelvic examination. In addition, a site-specific physical examination of the abdomen, thyroid, peripheral lymph nodes, digital rectal exam, and fecal occult blood testing offered to all over age 50. Methods: A retrospective review of all abnormal Pap smears and HPV results were evaluated during a 12-month time frame (2005–2006 calendar year). During this study period, 2611 women were screened for cervical cancer using the liquid based Pap smear. Characteristics which were reviewed included all ASCUS and LGSIL pap, percentage of abnormal results in the over age 65 group verses under age 65, and percentage of positive HPV tests. Standard protocol is to order a reflex high risk HPV on all ASCUS and LGSIL Pap smear test results. The age range for this population was 28 to 90 with the median age 53. Results: During the 12 month study time, 64 out of 2611, or 2.4% abnormal Pap smear reports were identified. Out of those 64, there were 37 (57.8%) ASCUS and 27 (42.1%) LGSIL Paps and 10 positive (15%) high-risk HPV results with 2 positive HPV (3.1%) being in women over age 65. Further break down by age revealed 13 (20%) of the ASCUS paps, and 6 (9.3%)LGSIL were in women over age 65, for a total of 19 (29.3%) of abnormal Pap smears in women over age 65. Conclusions: As women grow older the incidence of HPV infections become less, however the occurrence of cervical cancer increases. Therefore, continued Pap smear screening in older women with adjuvant high risk HPV testing can identify those women who need further invasive intervention for cervical cancer prevention. No significant financial relationships to disclose.
AB0021 In Psoriatic Arthritis Synovial Tissue Harbors Expanded T-Cell Clones Which Are not Fully Represented in Synovial Fluid or Blood Samples: Table 1
Authors: A. Musters, M.E. Doorenspleet, P.L. Klarenbeek, R.E. Esveldt, D.L. Baeten, D.M. Gerlag, P.-P. Tak, N. de Vries
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> T-cells play a key role in psoriatic arthritis (PsA). Nevertheless, the distribution and exact role of these cells remains unclear. Here, we study whether expanded T-cell clones are present in synovial tissue (ST), and whether such clones are also detectable in peripheral blood (PB) and synovial fluid (SF). <h3>Methods</h3> ST and SF from inflamed knees was sampled in 2 PsA patients together with paired PB samples. Using next generation sequencing T-cell clones were identified by their unique T-cell receptor β-chain sequence. Clones with a frequency of ≥0.5% were arbitrarily considered to be expanded. <h3>Results</h3> ST and SF samples from the same joint shared many of the expanded clones (see Table 1). Ninety percent (median, range 71-100%) of the expanded clones in ST were retrieved in SF, 33% of these being expanded in both samples. ST clones accounted for 14% of the SF T-cell repertoire. In PB 83% of the expanded ST clones were retrieved, 17% being expanded in both samples. Analysis of both inflamed knees in patient 1 showed that 83% of the expanded ST clones in the left knee were retrieved in the right knee, 80% of these being expanded in both. <h3>Conclusions</h3> In PsA synovial tissue harbors expanded T-cell clones, which are not fully represented in synovial fluid or blood samples. Preliminary analysis indicates that different joints contain identical expanded T cell clones. Our results suggest that in PsA comprehensive analysis of inflammation-related expanded clones best focuses on ST, rather than PB and SF. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4456
STENT THROMBOSIS: INSIGHTS ON OUTCOMES, PREDICTORS AND IMPACT OF DUAL ANTIPLATELET THERAPY INTERRUPTION FROM THE SPIRIT II, SPIRIT III, SPIRIT IV AND COMPARE TRIALS
Authors: Elvin Kedhi, Gregg Stone, Dean Kereiakes, Patrick Serruys, Helen Parise, Martin Fahy, Charles Simonton, Krishnan Sudhir, Poornima Sood, Pieter Smits
Journal: Journal of the American College of Cardiology (2012)
NEOPLASIAS PANCREÁTICAS METASTÁSTICAS: DIAGNÓSTICO MEDIANTE ULTRASONOGRAFÍA ENDOSCÓPICA
Authors: D Martínez, B Romero, MJ Álvarez, B San Millán, L Cid Gómez, I Martín-Granizo, JI Rodríguez, E Feteira, A Antúnez, MI Perez, S Bargiela
Journal: Endoscopy (2014)

Introducción: Las metástasis pancreáticas representan formas poco habituales de neoplasias malignas pancreáticas, siendo las más habituales las metástasis de carcinoma de células renales y de pulmón. El carcinoma medular de tiroides, los procesos linfoproliperativos y otras neoplasias son otras causas más raras de metástasis pancreáticas.
Effects of Childhood Leukemia and Chemotherapy on Puberty and Reproductive Function in Girls
Authors: Ethel S. Siris, Brigid G. Leventhal, Judith L. Vaitukaitis
Journal: New England Journal of Medicine (1976)

Longer survivial in childhood leukemia prompted this study of pubertal development and reproductive function in 35 girls and women. Twenty-eight patients (80 per cent) had normal pubertal progression during a median of 74 months after diagnosis of leukemia and 49 months of chemotherapy. Seven patients were abnormal: four exhibited hypothalamic-pituitary dysfunction with suppression of circulating serum gonadotropins (less than 6 mlU per milliliter); three others had evidence of primary ovarian dysfunction - reversible in two - with inappropriately elevated circulating serum gonadotropins (follicle-stimulating hormone greater than 20 mlU per milliliter). Normal sexual development correlated best with pubertal status at onset of leukemia; only one of 17 patients with diagnosis before puberty experienced altered pubertal progression, whereas abnormalities appeared in six of 18 with onset during puberty or after menarche. Thus, most girls with aggressively treated child-hood leukemia have an excellent prognosis for normal hypothalamic-pituitary-ovarian function; normal development is further enhanced in patients who are prepubertal at onset of leukemia.
Significant Enterogastric Reflux Secondary to Billroth II Gastrectomy Leads to Reverse Redistribution of the Inferior Wall of the Left Ventricle on Dipyridamole Tc-99m Tetrofosmin Myocardial SPECT
Authors: WEI-JEN SHIH, PATRICK DONOVAN, VICKIE KIEFER
Journal: Clinical Nuclear Medicine (2001)

SHIH, WEI-JEN M.D.; DONOVAN, PATRICK M.D., AND; KIEFER, VICKIE C.N.M.T. Author Information
Abstract 3008: Genome-wide siRNA screening identifies epigenetic silencing factor networks as potential targets for cancer therapy
Authors: Andrey S. Poleshko, Margret B. Einarson, Anna Marie Skalka, Richard A. Katz
Journal: Cancer Research (2011)

Abstract Epigenetic processes control the binary on-off states of specific gene sets, thereby creating heritable transcription patterns that drive development, and maintain cellular identity. The prominent epigenetic regulatory marks on eukaryotic chromatin are histone modifications and DNA cytosine methylation (5meCpG). These marks are placed by protein complexes, including members of the histone modifying and DNA methyltransferase (DNMT) enzyme families. It is hypothesized that errors in placement, removal, or reading of epigenetic marks can cause human disease through inappropriate silencing of specific genes. As the epigenetic marks that mediate gene silencing are reversible, there is interest in devising therapeutic strategies to reactivate epigenetically silent genes. Inhibitors of DNA methyltransferase (DNMT) and histone deacetylase (HDAC) enzyme families can reverse epigenetic silencing and produce anti-tumor effects, possibly through reactivation of silent tumor suppressor genes (so-called epigenetic therapy). As these inhibitors show limited specificity within enzyme families, their precise mechanisms of action are not well understood. To identify cellular factors involved in maintenance of epigenetic silencing, we constructed a population of human cells harboring epigenetically silent GFP reporter genes. Using this cell population we have implemented a GFP reporter-based siRNA knockdown screen to identify novel factors and networks that maintain epigenetic silencing in human cells. We have now completed a genome-wide, high throughput siRNA-based screen (21,122 siRNA targets). The screen has produced 128 gene hits that have satisfied several validating criteria. The output of this screen was of high quality, as several of the factors were identified in an earlier independent screen. Among the newly identified hits, there was a significant enrichment for factors that mediate SUMOylation, as well as 25 factors corresponding to novel genes, including 9 with no predicted functions. This screen has the potential to identify novel cellular pathways and reveal new targets for epigenetic therapy of cancer and other diseases. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3008. doi:10.1158/1538-7445.AM2011-3008
Single HLA Allele Mismatches Are Well Tolerated in the Recipients of T Cell Depleted Reduced Intensity Conditioned Transplants from Unrelated Donors.
Authors: Bronwen E. Shaw, Nigel H. Russell, Steve Devereux, Das-Gupta Emma, Mackinnon Stephen, J.Alejandro Madrigal, Anthony Pagliuca, Ghulam J. Mufti, Jenny L. Byrne
Journal: Blood (2005)
Dead in the water – are we killing the hospital autopsy with poor consent practices?
Authors: Jaimie Henry, Nick Nicholas
Journal: Journal of the Royal Society of Medicine (2012)

It is now a recognized fact that the practice of conducting a consent (or hospital) post-mortem examination is in decline. There have been many reasons put forth to explain this demise, but the quality of the consenting process is frequently cited as having a high impact. This article focuses on consent practices for post-mortem examinations in England and Wales, and considers if our consent techniques are adversely affecting post-mortem examination uptake. We examine the regulatory compliance of trusts with their statutory obligations by analyzing the Human Tissue Authority's compliance and inspection reports. We further analyze 21 publicly available NHS Trust policies on post-mortem examination consent procedures, and consider whether these are fit for the purpose of meeting the dual needs of clinicians and the bereaved. Despite more Human Tissue Authority inspections, there is a disproportionate rise in enforcement actions, with up to 48% of sampled Trusts exhibiting shortcomings in their legal duties. Additionally, only 52.4% of sampled trusts follow the Human Tissue Authority best-practice model, with 23.8% having no documented procedures. Despite the well founded evidence base for best-practice models, consent practices for post-mortem examinations remains poor and is likely to have a gross adverse effect on the rate of post-mortem examinations. We recommend that NHS Trusts rigorously review their protocols and introduce a team-approach between clinicians and trained bereavement staff in core-consent teams, as the Human Tissue Authority suggests, whilst at the same time placing a strong emphasis on education for junior and senior colleagues alike.
Cinemicrographic Studies on Granulopoiesis2
Authors: Y. T. Chang
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Cinemicrographic Studies on Granulopoiesis Get access Y. T. Chang Y. T. Chang Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 59, Issue 5, November 1977, Pages 1479–1489, https://doi.org/10.1093/jnci/59.5.1479 Published: 01 November 1977 Article history Received: 28 January 1977 Accepted: 27 June 1977 Published: 01 November 1977
SAT0151 Diastolic Dysfunction of the Left and Right Ventricles in Patients with Early Rheumatoid Arthritis Prior to Therapy with Basic Anti-Inflammatory Drugs: Table 1
Authors: I.G. Kirillova, D.S. Novikova, T.V. Popkova, Y.O. Korsakova, Y.N. Gorbunova, E.I. Markelova, A.V. Volkov, D.S. Kolmakova, D.E. Karateev, E.L. Nasonov
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> to determine the frequency of diastolic dysfunction (DD) of the left (LVDD) and right ventricles (RVDD) in patients with early RA prior to therapy with basic anti-inflammatory drugs (BAID), examine its relationship with traditional risk factors (TRF) of cardiovascular disease (CVD) and markers of inflammation. <h3>Methods</h3> a total of 76 patients (pts) with a valid diagnosis of RA (ACR/EULAR, 2010): 56 f (73,7%)/20 m (26,3%) were included, median (Me) age - 54 [interquartile range (IR) 45;60] years, Me duration-7 [IR 4;8] months; seropositive for IgM RF (87%) and/or ACCP (100%) without any experience of administration of BAID and glucocorticoides. All pts were assessed for TRF of CVD (ESC guidelines, 2011), ECG, 24-h ECG and blood pressure monitoring, echocardiography, tissue Doppler imaging, carotid artery ultrasound. Coronary calcium index was determined by 64-slice computed tomograph (the Agatston score). DD was allocated according to the ESC guidelines for the diagnosis and treatment of heart failure (2012). <h3>Results</h3> all pts with early RA demonstrated a high disease activity (Me DAS28–5,5, IR 5,0;6,1). LVDD was detected in 36 (48,6%) pts, RVDD-18 (24,7%). The prevailing type of LVDD and RVDD are I type: 31 (41,9%), 12 (66,7%); type II - 2 (4,1%), 5 (6,8%), type III - 2 (2,7%), 1 (1,4%) respectively. All pts were divided into 3 groups: 1 - pts with the LVDD and RVDD, 2 - with the LVDD, 3 - without ventricular DD, table 1. All groups were comparable in terms DAS 28, ACCP, RF. The frequency of carotid atherosclerosis, coronary artery calcinosis (CAC) and hypertension was higher in group 1 and 2 as compared with group 3. Ischemic heart disease (IHD) were more frequent in group 2 compared with group 3. Noted a progressive reduction of the concentration of HDL and an increase in triglycerides (TG), atherogenic index (AI) from 3 to 1 group. Body mass index (BMI) was higher in group 1 compared with group 3. CRP level was higher in pts with the presence of DD (29[11;55] mg/l, n=36) compared to those pts without the DD (14[6;41] mg/l, n=38, p&lt;0,05). There were negative correlation between the level of E/A LV and ESR (r=-0,3, p&lt;0,03), CRP (r=-0,3, p&lt;0,05); E/A RV and CRP (r=-0,3, p&lt;0,03), DAS28 (r=-0,3, p&lt;0,02). <h3>Conclusions</h3> in pts with early RA frequently (48,6%) were detected LVDD and RVDD, which are associated with a high incidence of CVD, TRF and the high activity of the inflammatory process. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4576