tbuckley/cabot-search huggingface dataset:
Delayed successful treatment of iatrogenic colon perforation using an over-the-scope clip
Authors: Gianfranco Donatelli, Bertrand Vergeau, Jean-Loup Dumont, Claude Altmann, Stravros Dritsas, Parag Dhumane, Thierry Tuszynski, Bruno Meduri
Journal: Endoscopy (2014)

Over-the-scope clip closure of iatrogenic gastrointestinal tract perforations has been successfully demonstrated, and is usually performed in the immediate peroperative setting [1] [2]. We report the first case, to our knowledge, of delayed successful treatment of an iatrogenic colon perforation using an over-the-scope clip.
P203 THE NEWLY AVAILABLE SEQUENCE-BASED GENOTYPING ASSAYS ARE MORE ACCURATE FOR HEPATITIS C VIRUS (HCV) GENOTYPING THAN PREVIOUS LINE-PROBE ASSAYS
Authors: M.J. Macartney, I. Abdi-Ashir, A.L. McCormick, W. Labbett, D. Irish, D.P. Webster, T. Haque
Journal: Journal of Hepatology (2014)
Abstract 871: A stratified genetic risk assessment for testicular cancer
Authors: Christian P. Kratz, Mark H. Greene, Jianxin Shi
Journal: Cancer Research (2011)

Abstract Three recent genomewide association studies (GWAS) of testicular germ cell tumors (TGCT) have uncovered predisposition alleles in or near several genes including KITLG, BAK1, SPRY4, TERT, ATF7IP and DMRT1. A candidate study has identified the so-called AZFc region as another risk locus on chromosome Y. We used a statistical approach to dissect the question of whether TGCT risk alleles can be utilized in the clinical setting. We employed the receiver operating characteristic curves for genetic risk models to measure the discriminatory power of a genetic risk model. The newly-discovered variants provided a discriminatory power of 69.2%, which was considerably higher than for other cancers analyzed with this method. This suggested that about 69.2% of the time, a randomly-selected patient with TGCT had a higher estimated risk than the risk for a randomly-selected control subject. Using a multiplicative model, we estimated that white men in the top 1% of genetic risk had a relative risk that was 10.5-fold greater than that for the general white male population in the US. Under the assumption that clinical risk factors such as cryptorchidism are not correlated with TGCT risk variants and do not interact with the TGCT loci as contributors to TGCT risk, white men aged 30-34 years with a history of cryptorchidism who were in the top 1% of genetic risk had an estimated 5-year risk of 4.4%. Other clinical risk factors such as family history and infertility could be also used in a stratified genetic risk assessment approach. Extensive statistical modeling and additional genotyping is required before such accurate risk estimates are feasible. We conclude that a genetic risk assessment is not justified in the general population at this time. However, a stratified genetic risk assessment strategy may be useful for men who have independent clinical risk factors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 871. doi:10.1158/1538-7445.AM2011-871
Abstract 5216: An Akt-EphA2 reciprocal regulatory loop controls tumor cell migration and invasion
Authors: Hui Miao, Hong Guo, Aaron Petty, Andrew Sloan, David Danielpour, James Basilion, Jennifer Cutter, John Sedor, Mark Cohen, Amitava Mukherjee, Bingcheng Wang
Journal: Cancer Research (2010)

Abstract EphA2 is a member of Eph family receptor tyrosine kinases that has been implicated in many types of human cancers. Perplexingly, both pro- and anti-oncogenic properties have been attributed to EphA2 kinase. We report here that a possible cause for this apparent paradox is diametrically opposite roles of EphA2 in regulating cell migration and invasion. While activation of EphA2 with its ligand ephrin-A1 inhibited chemotactic migration of glioma and prostate cancer cells, EphA2 overexpression promoted migration in a ligand-independent manner. Surprisingly, the latter effects required phosphorylation of EphA2 on serine 897 by Akt, and S897A mutation abolished ligand-independent promotion of cell motility. Ephrin-A1 stimulation of EphA2 negated Akt activation by growth factors and caused EphA2 dephosphorylation on S897. In human astrocytoma, S897 phosphorylation was correlated with tumor grades and Akt activation, suggesting that the Akt-EphA2 crosstalk may contribute to brain tumor progression. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5216.
A Man with Fever, Cough, and Rash
Authors: Bram J. Geller, Richard M. Stone, Joseph F. Merola, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2015)

A 67-year-old man with hairy-cell leukemia presented to the clinic after 3 days of fevers, night sweats, arthralgias, and an erythematous vesicular-appearing rash on his back. He had not had headache, shortness of breath, bleeding episodes, vomiting, or diarrhea.
P08.11 * SURGICAL MANAGEMENT OF BRAIN METASTASES FROM LUNG ADENOCARCINOMA: A SINGLE CENTER EXPERIENCE AND REFLECTIONS ON MULTIPLE LESIONS
Authors: R. Fornaro, A. Agnoletti, F. M. C. Specchia, D. Garbossa, M. Lanotte, A. Ducati
Journal: Neuro-Oncology (2014)

INTRODUCTION: Metastases are the most common intracerebral tumors, and they're expected to increase in the next years. Prognosis is linked to the progression of systemic and cerebral disease. Among patients in good conditions, removal of the cerebral metastasis represents the first treatment to apply. To evaluate the ideal conditions for surgery and its results we performed this single-center study on patients with solitary and multiple cerebral metastases. MATERIALS AND METHODS: We analyzed patients treated for cerebral metastasis between January 2004 and 2011. We considered only cases with non-small cell lung carcinoma (NSCLC) as primary tumor. We collected mortality and complication rates and analyzed the early outcomes before adjuvant therapy. Finally we used a χ2 test (p = 0.05) to assess if better early outcomes (improved or stable KPS) were significantly related to the presence of solitary VS multiple lesions. RESULTS: Our series included 199 patients; mean survival was 11.08 months. 95 patients harbored a single brain metastasis (Group 1) and 104 had more than one localization (Group 2). 67 patients underwent surgical operation. The mean pre-operative KPS was 75/100 in Group 1 and 65/100 in Group 2. After surgery in Group 1 the score improved in 69% of patients, was unchanged in 20% and worsened in 11%. In Group 2 the post-operative KPS was increased in 66% of cases, unchanged in 17% and worsened in 17% of cases. Statistical analysis did not show significant differences in the rates of good (KPS improved or stable) and poor outcomes in the two groups of operated patients. Patients with lesions in the posterior fossa improved after surgery more than those with supratentorial metastases. DISCUSSION: Observation of an high mortality for not-neurological causes confirms that modern treatments allow a significant control of the disease within the nervous system. Surgery entails the additional advantage of large tissue-samples availability for histological analysis that may influence targeted adjuvant therapies. The selection of surgical candidates should consider the patient conditions and size, number and location of the metastases. In the present cohort we observed a general improvement of quality of life related to surgery. 89% of patients in Group 1 and 83% in Group 2 underwent surgery without occurrence of additional impairment. Surgery was worth the risk to maintain a better quality of life. CONCLUSIONS: Management of cerebral metastases is a multidisciplinary job. Surgery allows an immediate control of local disease and can be considered also in multiple localizations. An accurate patient selection is related to acceptable quality of life in the months following surgery. Advances in the treatment of the systemic tumors is desirable for a significant improvement of the outcomes.
PARE0003 Get to know yourself – improve your quality of life
Authors: S. Makri
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Being a person with rheumatism implies social, economic and psychological problems. Feelings of low self esteem, low self image and a difficulty in accepting the fact of having a chronic disease- Feeling isolated from family members and friends- Feeling that others do not understand how you feel - Profound need to find ways to improve the psychology of patients and thus enhance self confidence. <h3>Objectives</h3> Helping people to handle chronic pain through discussions and exchange of experiences- Offering ways to the individual to deal effectively with chronic pain and be professionally active-Guiding patients on how to integrate again and be part of the social environment. <h3>Methods</h3> The "self awareness" workshops. Groups of 15-20 people. Each workshop is divided in 8 sessions which are held once a week at the premises of CYPLAR and their duration is 2 hours – coordinated by a qualified volunteer psychotherapist-Include anger management exercises, expression of emotions through discussions, relaxation techniques, positive thinking, visualization techniques, and meditation. <h3>Results</h3> Enhancement of the ability of dealing with chronic pain - regaining self confidence and self respect -improving self image-having less stress-being able to deal with difficult situations in life without losing self control -facing life in a more positive and optimistic way- ameliorating quality of life-being sociable-being positive-being creative. <h3>Conclusions</h3> Feeling of being "safe" again in the social environment – Ability to talk openly about having a chronic disease – reconstructing existing family, social and professional relationships. Building new social and professional relationships based on mutual trust-dealing with difficult situations at work and at home-Dealing more effectively with difficult situations at home and at work. <h3>Disclosure of Interest</h3> None Declared
CINE NMR IMAGING FOR QUANTIFICATION OF LEFT AND RIGHT VENTRICULAR VOLUMES, STROKE VOLUME RATIO AND REGURGITANT FRACTION
Authors: Jamshid Maddahi, Enrique Ostrzega, John Crues, Robert Siegel, Hiroshi Honma, John Friedman, Yzhar Charuzi, Daniel S. Berman
Journal: Clinical Nuclear Medicine (1987)

Maddahi, Jamshid; Ostrzega, Enrique; Crues, John III; Siegel, Robert; Honma, Hiroshi; Friedman, John; Charuzi, Yzhar; Berman, Daniel S. Author Information
SAT0426 Decreased Apprehension in Chronic Lumbar Pain : Accelerates Return to Work
Authors: M. Norberg, C. Schindler
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Chronic lumbar pain is expensive according direct and indirect costs. The most costly patients are them with sick-leave of more than 6 months. Several studies have showed grooving interest in rehabilitation models working on increased self confidence in these patients: one possibility is a multidisciplinary rehabilitation program. It treats the deconditioning situation on a interdisciplinary way. <h3>Objectives</h3> The aim of this study is to analyze the impact of a decrease of apprehension and its impact on work capacity over 2 years. <h3>Methods</h3> We have studied the results of 520 of our patients that have accomplished a multi-disciplinary program and that have been followed over 24 months. The program contained physical training, occupational work hardening the hole in a cogntivo-comportemental approach. We have analyzed the evolution of apprehension during time according to different pain and apprehension questionnaires (FABQ and Tampa scale (TSK); PACT evaluating the subjective work capacity). <h3>Results</h3> We saw a clear increase in the global work capacity, 24 months after completing the program: passing from 40 to 80.4%. In parallel there was an increase in the subjective sensation of physical capacity (Pact). This increase was correlated with a decrease in fear-avoidance evaluation according to the Fabq, and in the TSK. The return to work was not associated to an increase in physical performances but in an decrease in apprehension. <h3>Conclusions</h3> In chronic low back patients, with repeated work absences, a multidisciplinary rehabilitation program, has a positive effect on the apprehension. This correlation was presented on the psychological part, with less apprehension and also increased global SF 36 values. It brings a clear increase in work ability. In fact an increase in body confidence rests the important factor in these functional restoration programs. <h3>Disclosure of Interest</h3> None Declared
Abstract 913: Differential roles of SPARC in bladder carcinogenesis and metastasis
Authors: Neveen A. Said, Henry Frierson, Dan Theodorescu
Journal: Cancer Research (2011)

Abstract Secreted Protein Acidic and Rich in Cysteine (SPARC), also termed osteonectin and BM-40, exhibits highly regulated expression during normal development, in tissues undergoing remodeling and repair as well as in cancer. The role of SPARC in bladder cancer is still elusive. Therefore, we sought to investigate the differential roles of SPARC in bladder carcinogenesis, progression and metastasis. We developed a chemical carcinogen N-nitrosobutyl(4-hydroxybutyl) amine (BBN) fed to mice with targeted deletion of SPARC (SP−/−) and their wild type counterparts (SP+/+) in drinking water to induce bladder cancer. We found that SP−/− mice exhibited earlier onset of urothelial pathology (inflammation/atypia and dysplasia, P&amp;lt;0.01) that significantly rapidly progressed to carcinoma in situ (CIS, P&amp;lt;0.02) and muscle invasive disease (P&amp;lt;0.03) as compared to their SP+/+ counterparts. SP−/− mice also exhibited significantly higher incidence and frequency of multifocality (kidney involvement, P&amp;lt;0.02) as well as metastases to para-aortic lymph nodes (P&amp;lt;0.04) and lungs (P&amp;lt;0.03) than SP+/+ counterparts. Furthermore, SP−/− mice had significantly lower median survival than SP+/+ counterparts (27weeks versus 40weeks for SP−/− and SP+/+, respectively; P&amp;lt;0.0002). Comparative analysis of bladder tissue lysates harvested from SP−/− and SP+/+ mice with matched pathology and BBN-exposure revealed that the accelerated onset of bladder lesions in SP−/− compared to SP+/+ was due to the effect of SPARC inhibiting cell cycle progression. These effects correlated with increased accumulation of reactive oxygen species concomitant with DNA damage as determined by 8-OH-odeoxyguanosine, lipid peroxidation and increase in markers of protein oxidation, sulfiredoxin and nicotinamide-N-methyl transferase (NNMT). The significant increase in inflammation in SP−/− was associated with significant higher activation of transcription factors AP1 and NFκß compared to SP+/+. These findings indicate SPARC exerts distinct differential roles in modulating tumor-host interactions during the initiation, progression and lung metastasis of bladder cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 913. doi:10.1158/1538-7445.AM2011-913
2013 ACC/AHA GUIDELINE RECOMMENDATION ON BLOOD CHOLESTEROL REVISITED: PERCENT LDL-C REDUCTION OR ATTAINED LDL-C LEVEL OR BOTH FOR PROGNOSIS?
Authors: Sripal Bangalore, Rana Fayyad, John Kastelein, Rachel Laskey, Pierre Amarenco, David DeMicco, David Waters
Journal: Journal of the American College of Cardiology (2015)
FRI0489-HPR Meaning of work in patients with systemic sclerosis: A qualitative study
Authors: S. Decuman, V. Smith, S. Verhaeghe, M. Grypdonck, F. De Keyser
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic Sclerosis (SSc) is a severe autoimmune connective tissue disorder primarily characterized by skin changes, damage to internal organs and the presence of Raynaud phenomenon. The clinical manifestations have an impact on the level of participation, including the ability to work. The last years there is increasing research about prevalence of work transitions in patients with SSc. Studies are mainly focused on assessing patients by structured interviews, questionnaires, clinical examination, and other methods. The knowledge generated is not sufficient to get insight in the meaning of work transitions and their potential predictors or causes. A more patient oriented approach can be helpful to assess the patient's perspective and develop more adequate interventions. <h3>Objectives</h3> The aim of this study is to explore the meaning of work in patients with SSc. Factors influencing this meaning are explored. <h3>Methods</h3> The aims of the research require a qualitative approach. Semi-structured interviews are used for data collection. The interviews are transcribed and analyzed using the constant comparison method. NVIVO9<sup>©</sup> is used for coding the data. To advance interpretative analysis, a cyclic process of data collection and data-analysis is used. For this analysis, till now, twelve patients have been interviewed. Researcher triangulation is used to increase the validity of the analyses. <h3>Results</h3> Working entails a financial benefit allowing patients to have a certain degree of independence. Working also offers structure in life. Moreover employees pursue normality by performing a job and they consider it as an expression of their citizenship. Working gives patients the opportunity to develop their identity and offers them the possibility to socialize. The meaning of work is influenced among other by education, individuality of the patient, severity of the disease, age, duration of sick leave, years being in the labor force and content of the job. The meaning people give to working influences the actions they take and the decisions they make concerning work. <h3>Conclusions</h3> Being able to work has different meanings. Moreover these meanings are influenced by diverse factors and determine the actions patients take and the decisions they make. Till now the results are preliminary but they generate new ideas about the problem of work participation in patients with SSc. This study can initiate the development of a different kind/type of interventions. <h3>Disclosure of Interest</h3> None Declared
Abstract 1942: Lactoferrin interferes with the Akt-GSK3b-cyclin D1 growth signaling of human prostate cancer cells
Authors: Partha Banerjee, Shankar Jagadeesh, Albert Dobi, Shiv Srivastava
Journal: Cancer Research (2011)

Abstract The etiology of human prostatic carcinoma remains largely undefined. However, it is becoming clear that epigenetic inactivation of various tumor suppressor genes could play pivotal role in the development of various cancers including prostate cancer. One of such tumor suppressor is lactoferrin (LTF) gene. Epigenetic inactivation of LTF may contribute to the development of human prostate cancer. Ectopic expression of LTF or supplementation of bovine LTF in human prostate cancer cells that lack endogenous LTF expression resulted in reduced growth in vitro supporting a role for LTF as a putative tumor suppressor gene. Therefore, it is important to delineate the molecular mechanisms by which LTF regulates prostate cancer cell growth. In this investigation, we demonstrated that, purified bovine LTF treatment of LNCaP and PC3 cells blocked cell cycle progression and up-regulated cell cycle inhibitors, p15 (INK4b), p16 (INK4a), p21 (Cip1) and p27 (Kip1) and p57 (Kip2) in a dose dependent manner. As a consequence, Cdk4, Cdk6, cyclin D1 and cyclin E levels decreased significantly with bovine LTF treatment. Subsequently, LTF treatment decreased nuclear cyclin D1 and possibly facilitated its degradation. In order to examine the degradation of cyclin D1, we analyzed the levels of phospho-Akt-Ser473- and phospho-Akt-Thr308 after LTF treatment of LNCaP and PC3 cells. We observed that LTF dose dependently decreased phospho-Akt-Ser-473 and phospho-Akt-Thr-308 without altering the total Akt levels. As a consequence, activated GSK3-beta level increased, which is a known to degrade cyclin D1. In summary, this study shows that bovine LTF treatment can inhibit human prostate cancer cell growth by disrupting Akt-GSK3b-cyclin D1 signaling pathway. Lactoferrin, therefore, promises an encouraging therapeutic potential for prostate cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1942. doi:10.1158/1538-7445.AM2011-1942
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Authors: I. Sadaf Farooqi, Susan A. Jebb, Gill Langmack, Elizabeth Lawrence, Christopher H. Cheetham, Andrew M. Prentice, Ieuan A. Hughes, Mark A. McCamish, Stephen O'Rahilly
Journal: New England Journal of Medicine (1999)

Severely obese (ob/ob) mice are deficient in the adipocyte-derived hormone leptin, which acts on the hypothalamus to control appetite and energy expenditure.1 The administration of leptin to these mice corrects their obesity by reducing their food intake and increasing their energy expenditure.2–4 These mice also have hyperinsulinemia, corticosterone excess, and infertility, which also are reversed by treatment with leptin.5 In humans, serum leptin concentrations, in general, correlate positively with indexes of obesity.6,7 We previously described two cousins with severe, early-onset obesity and undetectable serum leptin concentrations who were homozygous for a frame-shift mutation in the leptin . . .
TEMPERATURE-RESPONSIVE MATERIALS MAY ACT AS EXTRACELLULAR MATRIX AND CELL VEHICLE FOR CARDIAC TISSUE ENGINEERING
Authors: Brisa Pena Castellanos, Daewon Park, Carlin S. Long, Valentina Martinelli, Susanna Bosi, Laura Ballerini, Maurizio Prato, Carmen Sucharov, Mark Jeong, Matthew R.G. Taylor, Robin Shandas, Luisa Mestroni
Journal: Journal of the American College of Cardiology (2015)