tbuckley/cabot-search huggingface dataset:
Abstract IA11: Dependency of prostate cancer on HNRNPL and its associated RNAs
Authors: Teng Fei, Yiwen Chen, Myles Brown, X. Shirley Liu
Journal: Cancer Research (2016)

Abstract RNA binding proteins (RBPs) play critical roles in RNA metabolism and underlie multiple cellular functions. However, how RBPs act in cancer remains obscure. Using an RBP-focused RNAi screen and a genome-wide CRISPR/Cas9 knockout screen, we identified HNRNPL as an RBP required for prostate cancer growth. To understand the HNRNPL function mechanistically, we profiled the HNRNPL-bound RNA landscape by RIP-seq and linked these RBP-RNA interactions to multiple RNA regulatory processes. HNRNPL directly regulates the alternative splicing of a set of associated RNAs, including those encoding the androgen receptor (AR), the key lineage-specific prostate cancer oncogene. Interestingly, HNRNPL also regulates circular RNA formation. Moreover, we identified LARP, a novel HNRNPL-associated long noncoding RNA (lncRNA), as a cofactor of HNRNPL's gene regulatory function. Collectively, our data reveal HNRNPL and its RNA partners as novel players in prostate cancer growth, suggesting the potential to target RBPs or RBP-RNA interactions therapeutically. Citation Format: Teng Fei, Yiwen Chen, Myles Brown, X. Shirley Liu. Dependency of prostate cancer on HNRNPL and its associated RNAs. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr IA11.
Agranulocytosis after Promazine Therapy
Authors: Anna-Marie Chirico, Salvatore Carfagno, Frederick Lytel
Journal: New England Journal of Medicine (1957)

RECENTLY a new phenothiazine derivative, promazine hydrochloride (10-[3-dimethylamino-n-propyl]-phenothiazine hydrochloride), has been introduced as an effective tranquilizing agent in the management of various acute mental disturbances. The pharmacologic properties of promazine (Sparine) were found to be similar to those of chlorpromazine (Thorazine)1; however, promazine appeared to be less toxic.2 , 3 It is believed that a report of a case of agranulocytosis after therapy with this drug will be of general interest. To our knowledge this toxic effect of promazine, with recovery, has not previously been reported.Case ReportA 46-year-old woman was admitted to the Medical-Surgical Building of Norristown State Hospital . . .
Asymmetries in the densities of white and gray matter in the brains of schizophrenic patients
Authors: J W Largen, M Calderon, R C Smith
Journal: American Journal of Psychiatry (1983)

Although the densities of gray and white matter of 25 schizophrenic or schizoaffective patients did not differ from those of controls, the schizophrenic patients had higher densities of gray and white matter in the right hemisphere than in the left.
Stimuli‐Regulated Enzymatically Degradable Smart Graphene‐Oxide‐Polymer Nanocarrier Facilitating Photothermal Gene Delivery
Authors: Hyunwoo Kim, Jinhwan Kim, Minkyung Lee, Hee Cheul Choi, Won Jong Kim
Journal: Advanced Healthcare Materials (2016)

Graphene oxide (GO) has attracted huge interest in the area of biomedical application due to its unique physicochemical properties, but the issue of long-term toxicity in the body remains unclear. Here, the rationally designed GO nanocarriers (ssPEG-PEI-GO) modified with polyethylene glycol (PEG) and branched polyethylenimine (BPEI) via disulfide linkage are described to control the biological activity of GO as a delivery carrier and its degradation in biological systems. The ssPEG-PEI-GO efficiently interacts with plasmid DNA (pDNA) to form a stable nanocomplex by electrostatic interaction. After cellular uptake, ssPEG-PEI-GO/pDNA complex can easily escape from endosomes by photothermal conversion of GO upon near-infrared irradiation and subsequent photothermally induced endosome disruption. After endosomal escape, reducing intracellular environment enables polymer dissociation and rapid gene release and therefore shows enhanced gene transfection efficiency with low toxicity in comparison with non-reducible amide-functionalized GO nanocarriers (amPEG-PEI-GO) and control BPEIs. Besides, dePEGylated GO nanocarrier, owing to its disulfide bond, exhibits higher entrapment by macrophages compared with amide-functionalized one and subsequently degrades in macrophage. The degradation process can be monitored by photoluminescence emitted from degraded GO. These results suggest new directions in the design of biodegradable and multifunctional GO-based nanocarrier for biomedical application.
Real-Time Tissue Elastography in the Assessment of Liver Stiffness
Authors: Yoichi Hiasa, Hironori Ochi, Masashi Hirooka
Journal: Hepatology (2012)

We thank Ferraioli et al. for their interest in our article.1 We appreciate their concern, and would like to provide more details about how we measured liver stiffness using real-time tissue elastography. With regard to the first question, we previously described how we set the region of interest (ROI) for measuring elasticity by real-time tissue elastography.2, 3 The area of the ROI placed on both the liver and the spleen parenchyma was within 2 × 1 cm. The size of the ROI in the small vessels was usually within 0.3 × 0.5 cm. We used mean values derived from five measurements. We identified from these that the elastic ratio is not influenced by the size of the ROI. The maximum and minimum lengths of the ROI measured in our previous study were 1.90 ± 0.12 (range, 1.5-2.0) and 0.90 ± 0.11 (range, 0.6-1.0) cm for the liver and spleen parenchyma, and 0.44 ± 0.07 (range, 0.3-0.5) and 0.28 ± 0.01 (range, 0.2-0.3) cm for small vessels.2 We also previously found that interobserver agreement in determining fibrosis stage at different liver sites and the elastic ratio calculated by the two examiners closely correlated, and did not significantly differ.3 This evidence indicated that a small variation in the size of the ROI would not affect the value of the elastic ratio determined using real-time tissue elastography. With respect to the second question, we carefully selected the ROI to exclude subcutaneous tissue. We confirmed the positioning of the ROI by comparison with a B-mode image when we set the ROI. This might be difficult to distinguish from the photograph in Supporting Fig. 2B, but the ROI was set within the liver parenchyma, and certainly excluded subcutaneous tissue. We thank you again for your interest and questions, and we hope that real-time tissue elastography will become popular among clinicians and contribute to evaluating liver stiffness in patients with nonalcoholic fatty liver disease (NAFLD) and to the differential diagnosis of nonalcoholic steatohepatitis (NASH) for such patients. Yoichi Hiasa M.D., Ph.D. Hironori Ochi M.D., Ph.D. Masashi Hirooka M.D., Ph.D. Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan
Cyclical patterns of states of mind in psychotherapy
Authors: M J Horowitz, C Milbrath, M Ewert, D Sonneborn, C Stinson
Journal: American Journal of Psychiatry (1994)

A quantitative study of shifts in states of mind was conducted to demonstrate a clinically useful mode of observation. This mode categorizes observations of a patient's mental state into well-modulated, overmodulated, undermodulated, and shimmering patterns.The authors used reliable systems for scoring a patient's state of mind on videotapes of all sessions of her brief psychotherapy and, using separate procedures, scored the topics of discourse. These data were then examined by means of a lagged log-linear sequential analysis for patterns of shifts from one state to another and for concurrent shifts in topics.The findings indicated nonrandom shifts in state. Patterns of shifting from a well-modulated state to alternative states and back again were overrepresented. Such shifts were related to conflictual topics of discourse.Observing such shifts in mental state may help psychotherapists to formulate the contents of conflict and also to make technical interventions to stabilize optimal states for doing the work of psychotherapy.
Alcohol and drug abuse consultation in the general hospital: a systems approach
Authors: M Galanter, T B Karsu, J F Wilder
Journal: American Journal of Psychiatry (1976)

The authors describe a program that is directed at assuring effective treatment and referral for alcoholic and addicted patients in a general hospital; the program was developed to assure maximal utlization of available addiction treatment facilities without adding to the hospital staff. Drawing on systems theory, the authors review both a pragmatic and a conceptual basis for psychiatric intervention with paraprofessional support to provide consultation to the general medical staff who treat alcoholic and addicted patients. They stress the feasibility of altering the nature of the hospital system to achieve more effective treatment for these patients.
Abstract A26: Cofactor of BRCA1 as a modulator of hepatocellular carcinoma growth and migration
Authors: Eman El Zeneini, Asma Amleh
Journal: Cancer Research (2016)

Abstract COBRA1 is one of the four subunits that make up the Negative Elongation Factor Complex (NELF) which is involved in the stalling of RNA polymerase II early during transcription elongation. As such, COBRA1 is able to regulate a substantial number of genes involved in a number of pathways, including cell cycle control, metabolism, cell proliferation and DNA repair. Even though it has been extensively studied over the years, the majority of these studies have mostly reported physiological roles. In the field of cancer, COBRA1 remains largely unexplored. The aim of our study was to investigate the functional role of COBRA1 in the tumorigenesis of hepatocellular carcinoma (HCC). We investigated the gene expression pattern of COBRA1 in HCC tumors using the publicly available Oncomine Cancer Microarray Database. Results from three different microarray datasets reveal the frequent overexpression of COBRA1 in HCC tumors versus their normal counterparts. To elucidate the biological significance for this overexpression in HCC, RNA interference was used to silence the expression of COBRA1 in the well differentiated cell line, HepG2. The silencing efficiency was confirmed by both RT-PCR and Western blot analysis. Interestingly, knockdown of COBRA1 resulted in a significant decrease in cell proliferation, accompanied by a concomitant decrease in the expression of the proliferation marker, Ki-67. A scratch wound healing assay revealed a significant decrease in the migratory potential of the HepG2 cells in culture as well upon COBRA1 knockdown. The silencing of COBRA1 was associated with a significant decrease in the expression of survivin, suggesting that survivin might be one of the mechanisms by which COBRA1 mediates its role in the tumorigenicity of HCC. Collectively, data findings presented here highlight an oncogenic role for COBRA1 in hepatocellular carcinoma. To the best of our knowledge, our study provides evidence for the first time to support a positive role for COBRA1 in the growth and migration of HCC. Note: This abstract was not presented at the conference. Citation Format: Eman El Zeneini, Asma Amleh. Cofactor of BRCA1 as a modulator of hepatocellular carcinoma growth and migration. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr A26.
Prognostic Value of Cpss Cytogenetic Risk Classification in Patients with CMML after Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Multicenter Study of the Chronic Malignancies Working Party of the EBMT
Authors: Christian Koenecke, Dirk-Jan Eikema, Sheree Hazelaar, Dietrich W. Beelen, Victoria Potter, Martin Bornhaeuser, Nicolaus Kröger, Jürgen Finke, Dietger Niederwieser, Peter Dreger, Yves Chalandon, Arnold Ganser, Johan Maertens, Noel Milpied, Guido Kobbe, Maija Itälä-Remes, Henrik Sengeloev, Gerard Socie, Per Ljungman, Didier Blaise, Ellen Meijer, Hendrik Veelken, Francesco Onida, Marie Robin, Ibrahim Yakoub-Agha
Journal: Blood (2018)
Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
Authors: Rebecca Gardner, David Wu, Sindhu Cherian, Min Fang, Laïla-Aïcha Hanafi, Olivia Finney, Hannah Smithers, Michael C. Jensen, Stanley R. Riddell, David G. Maloney, Cameron J. Turtle
Journal: Blood (2016)
Dietary fats: debate should consider foods rather than nutrients
Authors: Rosemary A Stanton
Journal: BMJ (2016)

The debate over types of fats stumbles, as it doesn’t look at the foods containing them.1 In studies such as the Sydney Diet Heart Study in the 1970s, participants were given a margarine with large amounts of trans fatty acids.2 It’s little wonder the results were negative.

Basing any recommendation …
Peri-alloHCT IL-33 administration expands recipient T-regulatory cells that protect mice against acute GVHD
Authors: Benjamin M. Matta, Dawn K. Reichenbach, Xiaoli Zhang, Lisa Mathews, Brent H. Koehn, Gaelen K. Dwyer, Jeremy M. Lott, Franziska M. Uhl, Dietmar Pfeifer, Colby J. Feser, Michelle J. Smith, Quan Liu, Robert Zeiser, Bruce R. Blazar, Hēth R. Turnquist
Journal: Blood (2016)
Cocaine use by senior medical students
Authors: S Conard, P Hughes, D C Baldwin, K E Achenbach, D V Sheehan
Journal: American Journal of Psychiatry (1989)

The authors studied 589 senior medical students' attitudes about and use of cocaine. Reported use was 36% in the students' lifetimes, 17% in the past year, and 6% in the past month. Overall, these rates were lower than those of an age-matched cohort.
Abstract P2-08-21: Stromal co-expression of urokinase-type plasminogen activator (uPA) and plasminogen activator Inhibitor (PAI-1) protein by IHC predicts poor disease outcome in endocrine-treated postmenopausal patients with receptor-positive early breast cancer
Authors: CF Singer, M Filipits, S Jahn, L Abete, R Jakesz, R Greil, T Bauernhofer, W Kwasny, M Seifert, F Fitzal, M Schmitt, F Moinfar, M Gnant
Journal: Cancer Research (2016)

Abstract Background Elevated levels of intratumoral uPA and PAI-1 in ELISA-based measurements are associated with a high recurrence risk and allow to identify patients who might particularly benefit from adjuvant chemotherapy. The clinical utility of ELISA-based protein analysis is, however, greatly limited by the requirement of fresh tumor tisssue. We have therefore evaluated in a large clinical trial patient cohort with long-follow-up whether immunohistochemical detection of uPA and PAI-1 in FFPE archived tumor samples is also able to identify women with poor prognosis. Patients and Methods 547 postmenopausal women with hormone receptor–positive, early breast cancer who had received at least 5 years of endocrine therapy in the prospectively designed ABCSG-06 trial, and in whom FFPE tumor tissue was available, were included in this analysis. uPA and PAI-1 protein expression was evaluated by immunohistochemistry, and correlated with distant-disease free (DDFS) and overall survival (OS). Results Stromal co-expression of uPA and PAI-1 was detected in 166 of 276 (60%) evaluable tumor samples and was weakly associated with tumor size (p=0.012, Chi Square test) but not with age, nodal status, grading, or receptor status. Women with intratumoral uPA/PAI-1 expression were more likely to have a shorter DDFS in multivariate analysis (HR for relapse p=1.870; 95% CI 1.184-2.955; p=0.007 Cox regression analysis) and and OS (adjusted HR for death p=1.291; 95% CI 0.928-1.795; p=0.129) than women without. After a median follow-up of 10 years, women with uPA/PAI-1-positive tumors experienced a significantly shorter DDFS (p&amp;lt;0.0001 log rank test) and OS (p=0.020). Conclusions Stromal co-expression of uPA and PAI-1 in breast cancer samples predicts poor DDFS and OS in postmenopausal women with hormone-receptor positive early-stage breast cancer who receive endocrine therapy. Citation Format: Singer CF, Filipits M, Jahn S, Abete L, Jakesz R, Greil R, Bauernhofer T, Kwasny W, Seifert M, Fitzal F, Schmitt M, Moinfar F, Gnant M. Stromal co-expression of urokinase-type plasminogen activator (uPA) and plasminogen activator Inhibitor (PAI-1) protein by IHC predicts poor disease outcome in endocrine-treated postmenopausal patients with receptor-positive early breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-08-21.
Psychiatry and the elderly: an overview
Authors: R N Butler
Journal: American Journal of Psychiatry (1975)

The author notes that the elderly in our society have not been provided with treatment, research, and services commensurate with their needs. These needs are reflected in the increasing incidence of psychopathology, suicide, and poverty with increasing age. The psychiatric profession's therapeutic nihilism toward the elderly may reflect unresolved countertransference issues that result in a form of prejudice called "ageism." Many of the conditions labeled "senility" are actually manifestations of socioeconomic or medical problems that could be resolved with prompt, appropriate treatment. The author makes several recommendations--the creation of a multidisciplinary nongovernmental commission on mental health and illness of the elderly, reexamination by psychiatrists of their attitudes toward the elderly, and proportionate representation of older individuals in psychiatric services, training, and research.
Judicium Parium
Authors: Alfred P. Fishman
Journal: New England Journal of Medicine (1974)

Etymologically "peers" are "equals" (pares), and in Anglo-Norman days the word was invariably so understood. The feudal tenants-in-chief of the Crown were all the peers of each other, whether the lords of one manor or of a hundred; so too a bishop had his ecclesiastical peer in a brother bishop, and the tenants of a manor their peers in their fellow-tenants. That even so late as the reign of John the word was still used in this general sense is clear from the Magna Carta, for the term "judicium parium" therein must be understood to mean that every man had . . .
Abstract 03: The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis
Authors: Kevin B. Jones, Jared J. Barrott, Huifeng Jin, Malay Haldar, Mario R. Capecchi
Journal: Clinical Cancer Research (2016)

Abstract Synovial sarcoma, the most common soft-tissue sarcoma in young adults bears a t(X;18) translocation that generates a fusion between SS18 (formerly SYT) and an SSX gene. SS18-SSX1 and SS18-SSX2 differ by only 13 amino acids. Clinically, SS18-SSX1 is more common, portends a worse prognosis, and demonstrates increased prevalence of biphasic histology. We conditionally expressed each fusion in otherwise identical mouse models, unexpectedly finding SS18-SSX2 to be more sarcomagenic than SS18-SSX1 and equally prone to biphasic histology. This suggested that coding sequence does not account for clinical differences between the fusions. Reanalysis of patient series found a gender bias in the prevalence of SS18-SSX2-expressing tumors, suggesting an X-linked effect and implicating the loss of native SSX2 by translocation as a hinderance to SS18-SSX2-driven synovial sarcomagenesis in males. Next, we confirmed that human synovial sarcomas almost universally express native SSX2, but not SSX1 and knock-down of native SSX2 in human synovial sarcoma cell lines blunted proliferation whereas overexpression of SSX2 enhances cell proliferation. In conclusion, we hypothesize that SSX2 facilitates sarcomagenesis in SS18-SSX1-expressing tumors and because our model of SS18-SSX2-expressing mice does not disrupt native SSX2 it recapitulates the prevalence and phenotype of SS18-SSX1 tumors. Citation Format: Kevin B. Jones, Jared J. Barrott, Huifeng Jin, Malay Haldar, Mario R. Capecchi. The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr 03.
Abstract P3-12-16: Hydrosorb® versus control (water based spray) in the management of radio-induced skin toxicity: Results of multicentre controlled randomized trial
Authors: L Bazire, I Fromentin, A Diallo, B de Lalande, V Pernin, R Dendale, A Fourquet, A Savignoni, Y Kirova
Journal: Cancer Research (2016)

Abstract Purpose: To report the results of a randomised study comparing the efficacy of Hydrosorb® versus control (water based spray) in the topical treatment of grade 1 and 2 radiation dermatitis in population of patients treated for early stage breast cancer (BC) with normo fractionated radiotherapy (RT). Patients and Methods: Breast cancer patients with grade 1-2 radio-induced dermatitis during normo fractionated postoperative radiotherapy were eligible (according to the CTCAE v3 scale). They were randomised to receive either Hydrosorb® (A) or water based spray (B). The primary endpoint was local treatment failure defined as interruption of radiotherapy because of skin radiotoxicity or and/or change of local cares for skin alteration. Secondary endpoints were the evaluation of skin colorimetry, pain, and quality of life. Pain was assessed according to two classes with a VAS cut-off of 2. Results: Two-hundred seventy eight patients were enrolled (A = 142, B = 136). There were 186 successfully treated patients (82 in Hydrosorb® arm, and 74 in the control arm). There were 60 "failures" in the Hydrosorb® arm, and 62 in the control arm (p = 0.72), but mostly without interruption of the radiotherapy. Twenty-four patients stopped the radiotherapy treatment for local cares (16 in Hydrosorb®, arm and 8 in control arm). No risk factors were associated with failure to local treatment. The average absolute reduction of colorimetric levels between day 28 and day 0 was 4 in the Hydrosorb®, and 4.2 in the water spray groups, respectively (p = 0.36). Forty-eight patients in the Hydrosorb® arm had a VAS &amp;gt; 2 versus 51 patients in the placebo arm, i.e. 34% and 38%, respectively (p = 0.45). A significant reduction of pain was observed on D7 (p = 0.04) and D21 (p = 0.01) in the Hydrosorb® arm. Sixty patients in the Hydrosorb® arm and 55 patients in the placebo arm had moderately to severely altered quality of life (p = 0.76). Conclusions: The present study showed no significant difference between Hydrosorb® and simple water spray in the treatment of acute radio-induced dermatitis even if there was a trend to an improvement in pain at the first weeks after the treatment. Systematic prevention measures and modern breast cancer radiotherapy techniques now allow excellent tolerability, but the place of topical treatment to optimize this tolerability has yet to be defined. Citation Format: Bazire L, Fromentin I, Diallo A, de Lalande B, Pernin V, Dendale R, Fourquet A, Savignoni A, Kirova Y. Hydrosorb® versus control (water based spray) in the management of radio-induced skin toxicity: Results of multicentre controlled randomized trial. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-12-16.