tbuckley/cabot-search huggingface dataset:
Accuracy of cancer information on the Internet: A comparison of a Wiki with a professionally maintained database.
Authors: M. S. Rajagopalan, V. Khanna, M. Stott, Y. Leiter, T. N. Showalter, A. Dicker, Y. R. Lawrence
Journal: Journal of Clinical Oncology (2010)

6058 Background: A Wiki is a website which can be directly, openly edited; Wikipedia, a collaborative encyclopedia, is a well-known example. Due to a Wiki's lack of editorial control and formal structure, we hypothesized that the content would be less complete and less accurate than that presented on a formal, peer-reviewed web site. Our goal was to compare the coverage, accuracy, and readability of cancer information from a Wiki (Wikipedia) with a peer-reviewed web site, the patient-oriented National Cancer Institute's Physician Data Query (PDQ) comprehensive cancer database. Methods: For each of ten cancer types, an appraisal form was created to include content of epidemiology, etiology, symptoms, diagnosis, treatment, and controversial topics in cancer care. Statements were obtained and validated from standard oncology texts. Medically-trained personnel scored PDQ and Wikipedia web pages for accuracy and presentation of controversies. Reliability was assessed using inter-observer variability (correlation coefficient) and test-retest reproducibility (Ebel's algorithm). Readability was calculated from word and sentence length. Results: Examiners were able to assess web sites rapidly, with a mean of 18 minutes per article. Test-retest reliability was 0.71. Inter-observer variability was 0.53. For both web sites, inaccuracies (as agreed upon by ≥ 2 raters) were rare and comprised < 2% of information examined. PDQ was significantly more readable than Wikipedia: Flesch-Kincaid grade level 9.6 ± 1.5 vs. 14.1 ± 0.5 (p < 0.0001). There was no difference in depth of coverage between PDQ and Wikipedia (29.9 ± 8.3, 34.2 ± 14.0 respectively; max. possible score 72). Controversial aspects of cancer care were relatively poorly discussed in both resources (2.9 ± 2.8 and 6.1 ± 6.3 for PDQ and Wikipedia respectively [NS]; max. possible score 18). A planned sub-analysis comparing common to uncommon cancers demonstrated no difference between the two for either resource. Conclusions: Although the Wiki resource had similar accuracy and depth to the professionally edited database, it was significantly less readable. Further research is required to assess how this influences patients' understanding and retention. No significant financial relationships to disclose.
Epidémie d’oreillons associée à une faible efficacité vaccinale – Porto, Portugal, 1996
Authors: G Gonçalves, A de Araújo, M. L. Monteiro Cardoso
Journal: Eurosurveillance (1998)

La vaccination contre les oreillons a debute en 1987 au Portugal avec l’introduction, dans le cadre du Programme national de vaccination (Programa Nacional de Vacinacao : PNV), du vaccin multiple ROR pour les enfants des deux sexes des l’âge de 15 mois. En novembre 1990, une seconde dose de vaccin administree entre 11 et 13 ans a ete ajoutee au PNV. En octobre 1992, a la suite d’effets secondaires attribues a la souche du virus des oreillons Urabe Am9 presente dans le vaccin utilise, le Ministere de la Sante portugais decidait de le remplacer par un vaccin ROR contenant la souche virale Rubini. Le premier stock de ce  nouveau  vaccin a ete livre a Porto et distribue aux Centres de sante du District en octobre 1992.
Preventing and controlling tuberculosis among refugees in Europe: more is needed
Authors: Masoud Dara, Ivan Solovic, Delia Goletti, Giovanni Sotgiu, Rosella Centis, Lia D'Ambrosio, Brian Ward, Vitor Teixeira, Christina Gratziou, Giovanni Battista Migliori
Journal: European Respiratory Journal (2016)

We read with interest the study by de Vries et al . [1] reporting on the results of tuberculosis screening among recently arrived migrants and refugees in the Netherlands. A coordinated effort is needed in Europe to ensure adequate diagnosis and treatment of tuberculosis among refugees <http://ow.ly/YEfXp>
Treatment of Common Parasitic Infections of Man Encountered in the United States
Authors: Harry Most
Journal: New England Journal of Medicine (1972)

Trematodes (Flukes)SchistosomesOf the three human species, Schistosoma mansoni, S. hematobium and S. japonicum, the last is the least prevalent and also the most difficult to treat. Of the several thousand infections acquired in the Philippines in World War II, very few present clinical problems now. Only a handful of cases of S. japonicum infection have recently occurred in Americans in Laos. Treatment is detailed elsewhere.3 The most effective therapy is time consuming and requires meticulous surveillance for toxicity. It involves the intravenous administration of progressively increasing doses of 0.5 per cent tartar emetic on alternate days until a . . .
Idiopathic Restrictive Cardiomyopathy Is Primarily a Genetic Disease
Authors: Maria Gallego-Delgado, Juan F. Delgado, Vicens Brossa-Loidi, Jesús Palomo, Raquel Marzoa-Rivas, Felix Perez-Villa, Joel Salazar-Mendiguchía, Maria J. Ruiz-Cano, Esther Gonzalez-Lopez, Laura Padron-Barthe, Belen Bornstein, Luis Alonso-Pulpon, Pablo Garcia-Pavia
Journal: Journal of the American College of Cardiology (2016)
Exercise: shifting fluid and sleep apnoea away
Authors: Christopher E. Kline
Journal: European Respiratory Journal (2016)

Sleep disordered breathing (SDB) is a prevalent sleep disorder [1, 2] with a wide array of potential adverse health consequences if left untreated, including cognitive impairment, type 2 diabetes, cardiovascular disease and early mortality [3–6]. The most common type of SDB, obstructive sleep apnoea (OSA), is strongly tied to excess weight [7] and afflicts up to 10% of adults [2]. Positive airway pressure (PAP) therapy is the most established treatment for OSA and central sleep apnoea (CSA), the other common type of SDB. PAP therapy is highly efficacious at reducing apnoeas and hypopneas during sleep, and its consistent use has been shown to reduce health risk to near non-SDB levels [8, 9]. However, its efficacy is dependent upon regular use, and long-term adherence to PAP is often unacceptably low [10]. Exercise may reduce SDB severity through reduction in nocturnal rostral fluid shift <http://ow.ly/4nbPZz>
Adoptive Immunotherapy for CMV Infection Complicating Haploidentical Transplants: Challenges Posed by the HLA Restriction of Immuno- Dominant Donor T Cells
Authors: Aisha Hasan, Ekatarina Doubrovina, Deepa Trivedi, Nancy A. Kernan, Susan Prockop, Richard J. O’Reilly
Journal: Blood (2008)
Guidance is needed on synthetic cannabinoid receptor agonists and cannabis
Authors: Ian Hamilton
Journal: BMJ (2016)

Millar’s personal account of “Spice” is a useful reminder that, although drugs are used by people from all socioeconomic groups, they acutely affect those who are socially disadvantaged.1 We’re collectively ignorant about a range of factors related to synthetic cannabinoid receptor agonists (SCRAs) and traditional forms of cannabis. We don’t have reliable information on …
In-situ second harmonic generation by cancer cell targeting ZnO nanocrystals to effect photodynamic action in subcellular space
Authors: Bobo Gu, Artem Pliss, Andrey N. Kuzmin, Alexander Baev, Tymish Y. Ohulchanskyy, Jossana A. Damasco, Ken-Tye Yong, Shuangchun Wen, Paras N. Prasad
Journal: Biomaterials (2016)
Melancholy
Authors: Michael D Stillman
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Experimental Hyperplastic Gastritis and Gastric Polyposis in Monkeys
Authors: Clarence C. Lushbaugh, Ph. D.
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Experimental Hyperplastic Gastritis and Gastric Polyposis in Monkeys Get access Clarence C. Lushbaugh, Ph. D. Clarence C. Lushbaugh, Ph. D. Toxicity Laboratory and Department of Pathology, University of Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 313–320, https://doi.org/10.1093/jnci/7.5.313 Published: 01 April 1947
Case 45-1968
Authors: Allan I. Sandler, Benjamin Castleman
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A seventy-two-year-old man was admitted to the hospital because of pain in the hips.Six weeks previously he began to experience pain in both hips, which was increased by exercise. Anorexia developed, with loss of weight. He had no swelling or tenderness in the joints, fever, sweats or chills, and there was no history of abdominal pain or jaundice. He drank beer on rare occasions. Three weeks before entry a physician administered penicillin. At about that time an episode of melena occurred.The patient was cachectic, with dry, scaly skin. No rash or spider angiomas . . .
Risk of staphylococcal infection runs in families
Authors: Jacqui Wise
Journal: BMJ (2016)

The risk of infection with Staphylococcus aureus bacteraemia may have a genetic component, a large Danish study published in Annals of Internal Medicine has found.1

The study showed that having a first degree relative, especially a sibling, who has been hospitalised with S aureus bacteraemia considerably increases a person’s risk for the disease regardless of the sex of the family …
Activation of C/EBPα in Hematopoietic Stem Cells Leads to Growth Suppression and Impairment of Megakaryocyte Differentiation.
Authors: Yumi Fukuchi, Fumi Shibata, Miyuki Ito, Yuko Goto-Koshino, Yusuke Sotomaru, Mamoru Ito, Toshio Kitamura, Hideaki Nakajima
Journal: Blood (2005)
A four-week oral toxicity study of 3,3’-diindolylmethane in dogs
Authors: Rajabather Krishnaraj, Robert L. Morrissey, James Crowell, Alexander V. Lyubimov
Journal: Cancer Research (2004)

738  Isothiocyanates (ITCs) are a class of phytochemicals that are especially abundant in cruciferous vegetables. Many ITCs have been repeatedly shown to inhibit chemical carcinogenesis in a variety of rodent organs. However, their effects on bladder carcinogenesis have been inconsistent. Dietary supplementation of 1-naphthyl-ITC or phenylhexyl-ITC (both are synthetic) has been shown to inhibit carcinogen-induced bladder tumorigenesis in rats, whereas chronically feeding rats allyl-ITC, benzyl-ITC, or phenethyl-ITC (PEITC) either enhanced or induced bladder carcinogenesis. A literature survey has led us to conclude that the bladder epithelium, where the majority of bladder tumor originates, is by far the most exposed tissue to dietary ITCs. Ingested ITCs are metabolized in vivo to N-acetylcysteine conjugates (NAC-ITCs), which are disposed and concentrated up to most likely several mM in urine, depending on the ITC dosage. Several NAC-ITCs also are known to inhibit carcinogenesis in non-bladder organs, primarily due to their facile dissociation to ITCs. We have therefore speculated that the observed carcinogenic effect of ITCs on the bladder in rodents might be related to the prolonged exposure of bladder epithelial cells to very high and toxic concentrations of NAC-ITCs/ITCs in urine stored in the bladder. In other words, overdosing of ITCs may be largely responsible for the adverse effects observed in the bladder. To support this concept, we report that AITC, BITC, and PEITC, as well as several other tested ITCs, all potently induce apoptosis, based on TUNEL assay, and arrest cell cycle progression, based on flow cytometry assay, in cultured human bladder carcinoma UM-UC-3 cells and T24 cells at 5-30 μM concentrations. Multiple caspases, including caspase-9, -8, and -3, as well as poly(ADP-ribose) polymerase, were cleaved upon ITC exposure. The ITCs blocked cell cycle progression at S and/or G2-M phases in these cells. A limited structure-activity analysis has been carried out, identifying PEITC as the most potent agent. Therefore, only very low concentrations of ITCs may be required for inhibition of bladder carcinogenesis. Interestingly, although many ITCs also are known to induce Phase 2 enzymes in a variety of cultured cells and animal tissues, only the activity of quinone reductase and the level of glutathione were somewhat elevated by the ITCs. No induction of glutathione transferase and UDP-glucuronosyltransferase were detected in the ITC-exposed cells, suggesting that ITCs may have limited effect on carcinogen metabolism in bladder cells. In summary, dietary ITCs display potent antiproliferative activity in cultured human bladder cancer cells and may inhibit bladder tumorigenesis in vivo if overdosing is avoided. Supported by NCI grant CA80962.
The Diagnostic and Prognostic Utility of 18F-FDG PET/CT in Transplant Ineligible Multiple Myeloma Patients Receiving Novel Agents
Authors: Yasunobu Takeoka, Ryosuke Yamamura, Taku Araki, Akiko Inaba, Yotaro Fujitani, Genju Koh, Hirotaka Seura, Terue Okamura, Kensuke Ohta
Journal: Blood (2013)
Tailoring the physicochemical properties of core-crosslinked polymeric micelles for pharmaceutical applications
Authors: Qizhi Hu, Cristianne J.F. Rijcken, Ethlinn van Gaal, Paul Brundel, Hana Kostkova, Tomas Etrych, Benjamin Weber, Matthias Barz, Fabian Kiessling, Jai Prakash, Gert Storm, Wim E. Hennink, Twan Lammers
Journal: Journal of Controlled Release (2016)
Confirmatory Testing for Onychomycosis
Authors: Shari R. Lipner, Richard K. Scher
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
BB02 Improves Therapeutical Effectiveness Of Extracorporeal Photopheresis With 8-MOP In a Murine Model Of Graft-Versus-Host Disease
Authors: David Garcia-Bernal, Miguel Blanquer, Jose Antonio del Rio, Enrique Correal, Maria del Carmen Algueró, Maria Juliana Majado, Jose María Moraleda
Journal: Blood (2013)
Vascular Reactions of Normal and Malignant Tissues in &lt;italic&gt;Vivo&lt;/italic&gt;. VI. The Role of Hypotension in the Action of Components of Podophyllin on Transplanted Sarcomas
Authors: G H ALGIRE, F Y LEGALLAIS, B F ANDERSON
Journal: JNCI Journal of the National Cancer Institute (1954)

Vascular Reactions of Normal and Malignant Tissues in Vivo. VI. The Role of Hypotension in the Action of Components of Podophyllin on Transplanted Sarcomas Get access Glenn H. Algire, Glenn H. Algire Laboratory of Biology, National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Frances Y. Legallais, Frances Y. Legallais Laboratory of Biology, National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Belle F. Anderson Belle F. Anderson Laboratory of Biology, National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 4, February 1954, Pages 879–893, https://doi.org/10.1093/jnci/14.4.879 Published: 01 February 1954 Article history Received: 22 April 1953 Published: 01 February 1954
The Effects of Oncologist Implicit Racial Bias in Racially Discordant Oncology Interactions
Authors: Louis A. Penner, John F. Dovidio, Richard Gonzalez, Terrance L. Albrecht, Robert Chapman, Tanina Foster, Felicity W.K. Harper, Nao Hagiwara, Lauren M. Hamel, Anthony F. Shields, Shirish Gadgeel, Michael S. Simon, Jennifer J. Griggs, Susan Eggly
Journal: Journal of Clinical Oncology (2016)

Health providers' implicit racial bias negatively affects communication and patient reactions to many medical interactions. However, its effects on racially discordant oncology interactions are largely unknown. Thus, we examined whether oncologist implicit racial bias has similar effects in oncology interactions. We further investigated whether oncologist implicit bias negatively affects patients' perceptions of recommended treatments (i.e., degree of confidence, expected difficulty). We predicted oncologist implicit bias would negatively affect communication, patient reactions to interactions, and, indirectly, patient perceptions of recommended treatments.Participants were 18 non-black medical oncologists and 112 black patients. Oncologists completed an implicit racial bias measure several weeks before video-recorded treatment discussions with new patients. Observers rated oncologist communication and recorded interaction length of time and amount of time oncologists and patients spoke. Following interactions, patients answered questions about oncologists' patient-centeredness and difficulty remembering contents of the interaction, distress, trust, and treatment perceptions.As predicted, oncologists higher in implicit racial bias had shorter interactions, and patients and observers rated these oncologists' communication as less patient-centered and supportive. Higher implicit bias also was associated with more patient difficulty remembering contents of the interaction. In addition, oncologist implicit bias indirectly predicted less patient confidence in recommended treatments, and greater perceived difficulty completing them, through its impact on oncologists' communication (as rated by both patients and observers).Oncologist implicit racial bias is negatively associated with oncologist communication, patients' reactions to racially discordant oncology interactions, and patient perceptions of recommended treatments. These perceptions could subsequently directly affect patient-treatment decisions. Thus, implicit racial bias is a likely source of racial treatment disparities and must be addressed in oncology training and practice.
Infliximab and CT-P13 immunogenicity assessment in PLANETAS and PLANETRAS main and extension studies: utility of laboratory methods description
Authors: Francesca Meacci, Mariangela Manfredi, Maria Infantino, Valentina Grossi, Maurizio Benucci
Journal: Annals of the Rheumatic Diseases (2016)

Infliximab and CT-P13 immunogenicity assessment in PLANETAS and PLANETRAS main and extension studies: utility of laboratory methods description Immunogenicity is known to be one of the main parameters to be considered during evaluation of the safety and efficacy of a biologic drug.The recent introduction in rheumatologic therapy of biosimilar drugs requires the comparison to the correspondent reference product (RP) of all their characteristics, included immunogenicity.2][3][4] Because of the great interest of clinicians in immunogenicity evaluation and the impact of the assay method used for the detection of the antidrug antibodies (ADAs), 5 in our opinion, some aspects of the mentioned studies should be pointed out.First, ADAs against both CT-P13 and IFX-RP were assessed by electrochemiluminescence, which is nowadays one of the more used detection methods, because of its high sensitivity and high drug tolerance. 6 7The neutralising capability of detected ADAs was assayed by a flowthrough immunoassay method Gyros Immunoassay (Gyros AB, Uppsala, Sweden), which is a microfluidic platform coupling high sensitivity and high drug tolerance.This technology has several more advantages, being also time saving and able to provide results with very low volumes of sample. 8Nevertheless, since this last method is still uncommon in most laboratories, some more description of the principle of the method and some more technical details about its application to the neutralising activity detection should be done, in order to better understand study results, and in order to encourage the diffusion of more performing laboratory methods.In addition, an inhibition test to confirm the specificity of ADAs detected would be clarifying.
Uterine-Cancer Morbidity in New York City and Its Relation to the Pattern of Regional Variation Within the United States
Authors: William Haenszel, Margaret Hillhouse
Journal: JNCI Journal of the National Cancer Institute (1959)

The results of a New York City uterine-cancer morbidity survey are presented. Cervical- and corpus-cancer incidence rates were computed, taking into account age, race, ethnic group, and histologic type. Wide variation in incidence among racial and ethnic groups was noted for cervical cancer but not for corpus cancer. Jewish women had very low cervical-cancer rates. The New York City results were generally consistent with observations reported from other Northern areas of the United States. The collective findings of morbidity surveys and related studies within the United States point to a regional difference in cervical cancer but not in corpus cancer, the cervical rates being higher for white women in the South. Several characteristics known to be associated with cervical cancer—marital status, age at marriage, child-bearing history, socioeconomic status, circumcision of husband, and syphilis—could account for part, but not all, of the regional difference.
General Histophysiology and Histopathology of the Liver&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;
Authors: W. Stanley Hartroft
Journal: JNCI Journal of the National Cancer Institute (1955)

General Histophysiology and Histopathology of the Liver Get access W. Stanley Hartroft W. Stanley Hartroft Department of Pathology, Washington University, St. Louis, Mo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue Supplement_5, April 1955, Pages 1463–1468, https://doi.org/10.1093/jnci/15.Supplement_5.1463 Published: 01 April 1955
Early influenza vaccine effectiveness results 2015-16: I-MOVE multicentre case-control study
Authors: E Kissling, M Valenciano
Journal: Eurosurveillance (2016)

Preview this article: Early influenza vaccine effectiveness results 2015-16: I-MOVE multicentre case-control study, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/21/6/eurosurv-21-30134-4-1.gif