Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression
Authors: Gerald Gartlehner, Bradley N. Gaynes, Catherine Forneris, Kathleen N. Lohr
Journal: Annals of Internal Medicine (2016)

Letters20 September 2016Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major DepressionGerald Gartlehner, MD, MPH, Bradley N. Gaynes, MD, MPH, Catherine Forneris, PhD, ABPP, and Kathleen N. Lohr, PhD, MPhil, MAGerald Gartlehner, MD, MPHFrom RTI International, Research Triangle Park, North Carolina, and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Search for more papers by this author, Bradley N. Gaynes, MD, MPHFrom RTI International, Research Triangle Park, North Carolina, and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Search for more papers by this author, Catherine Forneris, PhD, ABPPFrom RTI International, Research Triangle Park, North Carolina, and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Search for more papers by this author, and Kathleen N. Lohr, PhD, MPhil, MAFrom RTI International, Research Triangle Park, North Carolina, and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0209 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Rásky and Ms. Groth raise an important point: whether sex and gender influence the benefits and harms of depression treatments. In recent years, the importance of potential differences between men and women has resulted in considerable efforts to understand the role of these factors in health and disease (1). This issue is particularly relevant for depressive illnesses, because women are up to 3 times more likely to be diagnosed with depression than men (2).That we did not provide information about sex and gender in our article is attributable largely to gaps in data. Our review summarizes ...References1. Wizemann TM, Pardue ML. Exploring the Biological Contributions to Human Health: Does Sex Matter? Washington, DC: National Academies Pr; 2001. Google Scholar2. Kessler RC. Epidemiology of women and depression. J Affect Disord. 2003;74:5-13. [PMID: 12646294] CrossrefMedlineGoogle Scholar3. Gartlehner G, Gaynes BN, Amick HR, Asher G, Morgan LC, Coker-Schwimmer E, et al. Nonpharmacological Versus Pharmacological Treatments for Adult Patients With Major Depressive Disorder. Comparative Effectiveness Review no. 161. Rockville: Agency for Healthcare Research and Quality; 2015. [PMID: 26764438] Google Scholar4. Gartlehner G, Chapman A, Strobelberger M, Thaler K. Differences in efficacy and safety of pharmaceutical treatments between men and women: an umbrella review. PLoS One. 2010;5:e11895. [PMID: 20689584] doi:10.1371/journal.pone.0011895 CrossrefMedlineGoogle Scholar5. Gartlehner G, Forneris CA, Brownley KA, Gaynes BN, Sonis J, Coker-Schwimmer E, et al. Interventions for the Prevention of Posttraumatic Stress Disorder (PTSD) in Adults After Exposure to Psychological Trauma. Rockville: Agency for Healthcare Research and Quality; 2013. [PMID: 23658936] Google Scholar Author, Article, and Disclosure InformationAffiliations: From RTI International, Research Triangle Park, North Carolina, and University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M15-1813. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression: An Evidence Report for a Clinical Practice Guideline From the American College of Physicians Gerald Gartlehner , Bradley N. Gaynes , Halle R. Amick , Gary N. Asher , Laura C. Morgan , Emmanuel Coker-Schwimmer , Catherine Forneris , Erin Boland , Linda J. Lux , Susan Gaylord , Carla Bann , Christiane Barbara Pierl , and Kathleen N. Lohr Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression &Eacute;va Rásky and Sylvia Groth Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression Alain Braillon , Jérémy Fonseca Das Neves , and Francoise Taiebi Metrics Cited byCitation screening using crowdsourcing and machine learning produced accurate results: Evaluation of Cochrane's modified Screen4Me serviceSingle-reviewer abstract screening missed 13 percent of relevant studies: a crowd-based, randomized controlled trialASCENDing to New Heights in Our Understanding of the Treatment of Depression Among Individuals Receiving HemodialysisJennifer E. Flythe, MD, MPHWeb-Based Tools and Mobile Applications To Mitigate Burnout, Depression, and Suicidality Among Healthcare Students and Professionals: a Systematic Review 20 September 2016Volume 165, Issue 6Page: 454KeywordsCognitive behavior therapyDisclosureHealth insurancePatientsPosttraumatic stress disorderRacial and ethnic issuesResearch quality assessmentRisk managementSexual dysfunctionSexual identity ePublished: 20 September 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...