tbuckley/cabot-search huggingface dataset:
Abstract 15183: Effector T Cell Suppression Using Anti-CD3 Antibody Induces the Regression of Established Atherosclerosis in Mice
Authors: Tomoyuki Kita, Tomoya Yamashita, Masafumi Takeda, Kenji Nakajima, Ken-ichi Hirata
Journal: Circulation (2010)

Background:  Although recent clinical trials demonstrated that regression of atherosclerosis is achieved in human, the mechanisms of atherosclerosis regression are not fully elucidated. Anti-CD3 antibody (CD3-Ab) is an immunosuppressive agent and is reported to inhibit atherosclerosis. Intravenous injection of CD3-Ab dramatically decreased CD4 +  effector T cells, while its oral administration increased regulatory T cells (Tregs), and each of them contributes towards preventing atherosclerosis. The present study tested the hypothesis that treatment of CD3-Ab will induce regression of existing atherosclerotic lesions in mice.   Methods and Results:  We set up a new atherosclerosis regression model using LDL-receptor deficient mice. After 8 weeks exposure of high cholesterol diet, the diet was changed to normal chow at 14 weeks of age and kept for 4 weeks. We confirmed that there is no significant change in the atherosclerotic lesion size at aortic root by only changing the chow. However, intravenous administration of CD3-Ab in addition to normalizing plasma cholesterol significantly regressed atherosclerotic lesions (4.90±0.26×10 5  μm 2 , P 5  μm 2 ). Intravenous administration of CD3-Ab markedly decreased the number of CD4 +  effector T cells (−53.3% vs. control). Oral administration of CD3-Ab never affected the atherosclerotic lesion size at aortic root though Tregs were significantly increased.   Conclusions:  Intravenous CD3-Ab therapy induces the regression of established atherosclerosis via dramatic reduction of CD4 +  effector T cells. These results implied the possibility that the intervention to the number and function of effector T cells could be a hopeful therapy to achieve the regression of atherosclerosis.
CMS-07LONG TERM FOLLOW UP WITH DTI FIBER TRACTOGRAPHY OF CEREBRO-CEREBELLAR PATHWAYS AND CLINICAL EVALUATION OF ATAXIA IN CHILDHOOD POSTERIOR FOSSA TUMOR SURVIVORS
Authors: Ulrich-W. Thomale, Myung Eun Oh, Elisabeth Koustenis, Stefan Rückriegel, Rajiv Khajuria, Harald Bruhn, Pablo Hernaiz
Journal: Neuro-Oncology (2016)
Pharmacokinetic evaluation of Shenfu Injection in beagle dogs after intravenous drip administration
Authors: Yuqiao Zhang, Dali Tian, Yuyou Huang, Ling Li, Juan Mao, Juan Tian, Jinsong Ding
Journal: Acta Pharmaceutica Sinica B (2016)

Shenfu Injection (SFI) is a well-defined Chinese herbal formulation that is obtained from red ginseng and processed aconite root. The main active constituents in SFI are ginsenosides and aconitum alkaloids. In this work, ginsenosides (ginsenoside Rg1, ginsenoside Rb1 and ginsenoside Rc) and aconitum alkaloids (benzoylmesaconine and fuziline) were used as the index components to explore the pharmacokinetic behavior of SFI. A selective and sensitive HPLC-MS/MS method was developed for the quantification of ginsenosides and aconitum alkaloids in dog plasma and was used to characterize the pharmacokinetics of the five index components after intravenous drip of three different dosages of SFI in beagle dogs. The pharmacokinetic properties of the index components were linear over the dose range of 2-8 mL/kg.
“Jumping Frenchmen of Maine”
Authors: H Stevens
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Microarray Analysis and Tumor Classification
Authors: Daniel W Lin, Peter S Nelson
Journal: New England Journal of Medicine (2006)

for the Caffeine for Apnea of Prematurity Trial Investigators Bauer J, Maier K, Linderkamp O, Hentschel R. Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea. Pediatrics 2001;107: 660-3. Davis PG, Thorpe K, Roberts R, Schmidt B, Doyle LW, Kirpalani H. Evaluating “old” definitions for the “new” bronchopulmonary dysplasia. J Pediatr 2002;140:555-60. Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS, Whitfield MF. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. JAMA 2003; 289:1124-9. 1.
LG-70DISSEMINATED LOW GRADE GLIOMA IN CHILDREN AND ADOLESCENTS- A RETROSPECTIVE REVIEW OF TREATMENT OUTCOME IN A SINGLE CENTRE
Authors: Louise Davidson, Rowen Bell, Kim Phipps, Yenching Chang, Mark Gaze, Sara Stoneham, Antony Michalski, Ananth Shankar
Journal: Neuro-Oncology (2016)
Doxycycline for the Prevention of Tick-Borne Relapsing Fever
Authors: Ashley M Croft, Christopher J Jackson, Alicia H Darbyshire
Journal: New England Journal of Medicine (2006)

is safe and efficacious for the prevention of tickborne relapsing fever (TBRF) in a person who has been bitten by an infected tick. We dispute both points. Healthy male soldiers, who were the subjects in the study, are not an appropriate population for determining drug safety. General travelers are a more suitable study group for this purpose. A survey of 383 Australian tourists taking doxycycline (100 mg daily) as chemoprophylaxis against malaria found that 15% reported nausea and vomiting, 12% reported diarrhea, and 9% of women reported vaginal itch. 2 Other studies have linked doxycycline taken prophylactically with photoallergic rash and with photoonycholysis. 3 Adverse drug effects affect compliance and, hence, drug efficacy. 4 The safe and effective way to prevent TBRF is to pretreat clothing, including military uniforms, with a synthetic pyrethroid insecticide such as permethrin. Both hard ticks (Ixodidae) and soft ticks (Argasidae) are acutely sensitive to pyrethroids, and all stages of tick in these families will avoid attachment to humans who have sprayed or impregnated their clothing with permethrin. 5
Adverse interactions between cytotoxic drugs and hormonal agents in human breast cancer cells.
Authors: R Clarke, H W van der Berg
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.10.1580 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2778487 Adverse interactions between cytotoxic drugs and hormonal agents in human breast cancer cells. R ClarkexR ClarkeSearch for articles by this author , H W van der BergxH W van der BergSearch for articles by this author https://doi.org/10.1200/JCO.1989.7.10.1580 First Page PDF © 1989 by American Society of Clinical Oncology
TRACHEOSTOMY FOR ADVANCED EMPHYSEMA
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Endoscopic Retrograde Cholangiopancreatography Topics
Authors: E L Fogel
Journal: Endoscopy (2003)

While advances in pancreaticobiliary therapeutics continue to be made, endoscopists are too frequently reminded of the inherent risks of endoscopic retrograde cholangiopancreatography (ERCP). Prevention of postprocedural complications was the focus of several abstracts this year. While pharmacological prevention of post-ERCP pancreatitis has largely been disappointing, two abstracts reported results from well-designed, randomized, placebo-controlled trials evaluating heparin and transdermal glyceryl trinitrate.
Review: In peri- or postmenopausal women, DHEA does not improve symptoms and increases androgenic side effects
Authors: Donna M. Fedorkow
Journal: Annals of Internal Medicine (2015)

Source Citation Scheffers CS, Armstrong S, Cantineau AE, Farquhar C, Jordan V. Dehydroepiandrosterone for women in the peri- or postmenopausal phase. Cochrane Database Syst Rev. 2015;1:CD011066. 25609024
MB-08FUNCTIONAL ROLES OF CCL2 IN MEDULLOBLASTOMA LEPTOMENINGEAL METASTASIS
Authors: Noriyuki Kijima, Livia Garzia, A Morrissy, Laura Donovan, Xiaochong Wu, Betty Luu, Vijay Ramaswamy, John Peacock, Borja Lopez-Holgado, Xin Wang, Florence Cavalli, Adi Roider, David Shih, Patryk Skowron, John Lee, Antony Michealraj, David Malkin, Daniel Fults, Marco Marra, Michael Taylor
Journal: Neuro-Oncology (2016)
BMA Annual Representative Meeting: BMA criticises proposal for top-up fees
Authors: Linda Beecham
Journal: BMJ (2003)

The BMA has unanimously opposed the government's proposal to impose top-up fees or graduate taxes. At its annual representative meeting, it called on ministers to abandon the idea because it believes that it will adversely affect the future recruitment of doctors to all specialties. Medical students are facing debts of up to £45 000 ($27 000; €65 500) when they qualify, and, with the prospect of medical schools being able to increase tuition fees from £1100 to £3000 per student per year, the debts will increase. Ms Liz Kingston from the medical students conference told the meeting that 70% of the medical students at Liverpool came from professional or middle class backgrounds. The diversity the government wished to see would not be achieved if top-up fees were introduced, she said. Mr Ben Carrick, a medical student from Lothian, said that students were beginning to look at university courses and asking themselves whether they would be able to survive for five years at medical school. Many thought that they would prefer to follow a three year course in a different subject and not face huge debts. The number of applications from people from non-professional backgrounds was declining, and yet these were just the people that medical schools needed to attract. Medicine must not be limited to those students who could afford to pay, Mr Carrick said.
Genetic Diversity of Spontaneously Developed Primary and Metastatic Mammary Tumor Cells in Mice
Authors: Nurul H. Sarkar
Journal: Cancer Communications (1990)

Metastatic cells are often considered to be clonal derivatives of one of the primary tumor cell subpopulations. To determine if the cells of spontaneously developed lung nodules in a mammary tumor-bearing mouse represent the major or minor population of the cells in the primary tumor, comparisons were made of the pattern of their mouse mammary tumor virus (MMTV) proviral integrations, and their insertional mutations of the mouse mammary tumor proto-oncogenes, int-1 and int-2. Of the 78 tumor-bearing C3H/He mice sacrificed, seven mice showed metastatic lung nodules, but only four mice had nodule tissues adequate for the present analysis. Examination of the primary tumors and the corresponding lung nodules of these four mice revealed that the number of newly integrated MMTV proviruses and their sites of integration in the genomic DNAs of primary tumors and tumor nodules were variable, and that the int-1 gene was disrupted in three of the primary tumors but not in any of the metastasized tumor tissue. These results support the notion that, at least in some mice, the majority of cells constituting the primary mammary tumors and the corresponding metastases are of different genotypes and raise the possibility that the activation of different int-proto-oncogenes may be involved in the genesis of different cell subpopulations including metastatic cells in the same mouse.
Carcinogenic Action of the Mustards&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: W. E. Heston
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article Carcinogenic Action of the Mustards Get access W. E. Heston W. E. Heston National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 2, October 1950, Pages 415–423, https://doi.org/10.1093/jnci/11.2.415 Published: 01 October 1950 Article history Received: 20 August 1950 Published: 01 October 1950
Suspected Urine Leak in a Pediatric Renal Transplant Patient With Prune Belly Syndrome
Authors: Bin Liu, Summer L. Kaplan, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2015)

Patients with prune belly syndrome usually have tortuous ureters, which can cause difficulty in the interpretation of renal scan used to evaluate possible urine leak after renal transplant. We reported a renal scan finding in a pediatric renal transplant patient with prune belly syndrome. The radioactivity in the dilated ureter, which was lateral to the renal transplant, appears to be urine leak.
Preliminary Study on Detecting the SARS-CoV Specific Target cDNA Fragments by Multiplex PCR
Authors: Wenbing Chen, Shousong Li, Biying Shao, Teng Zheng, Shuxun Jiang, Xiaorong Huang, Kaizhen Cai, Zhideng Zhang
Journal: Genomics Proteomics & Bioinformatics (2004)

Abstract The multiplex polymerase chain reaction (PCR) technique was applied to detect the SARS-CoV (severe acute respiratory syndrome-associated coronavirus) specific target cDNA fragments in the present study. The target cDNA fragments of SARS-CoV were synthesized artificially according to the genome sequence of SARS-CoV in GenBank submitted by The Chinese University of Hong Kong, and were used as simulated positive samples. Five primers recommended by World Health Organization (WHO) were used to amplify the fragments by single PCR and multiplex PCR. Three target cDNA fragments (121, 182 and 302 bp), as well as the three different combinations of any two of these fragments, were amplified by single PCR. The combination of these three fragments was amplified by multiplex PCR. The results indicated that the multiplex PCR technique could be applied to detect the SARS-CoV specific target cDNA fragments successfully.
Association of Androgen Deprivation Therapy With Alzheimer’s Disease: Unmeasured Confounders
Authors: Jeffrey J. Leow, Alexander P. Cole, Maxine Sun, Quoc-Dien Trinh
Journal: Journal of Clinical Oncology (2016)

approach was used to extract routine administrative and clinical data from electronic medical records of two major academic centers in the United States, found a positive and seemingly duration-dependent association between androgen deprivation therapy (ADT) and Alzheimer’s disease (AD) among a cohort of 16,888 men with prostate cancer. The authors should be commended for their novel data-mining approach to address a salient clinical question. The methods may represent the foundation for many big data studies to come. We have several methodologic concerns. First, presence and duration of ADT is based on the presence of any one of 29 different wordsinelectronicmedicalrecords,whichrefer toaheterogeneous group of medications with disparate mechanisms and physiologic effects. For example, gonadotrophin-releasing hormone (GnRH) agonists downregulate the hypothalamic–pituitary–gonadal axis by chronic stimulation of GnRH receptors in the anterior pituitary and, thus, cause an initial surge in luteinizing hormone (LH) and testosterone. Other medications block GnRH or androgen receptors, which causes no such surge. Furthermore, different forms of ADT have different effects on gonadotropin levels: GnRH agonists mainly reduce LH, whereas GnRH antagonists reduce follicle-stimulating hormone and LH. Antiandrogens increase both. Given that receptors for GnRH, LH, and follicle-stimulating hormone are found in a wide variety of substrates—some with important inflammatory, vascular, and metabolic roles—it is unsurprising that differential adverse effects may be seen between forms of ADT. 2,3
The Antigens of Human Leukocytes. II. The Specificity of Leukocyte Antigens&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Leonhard Korngold, Gerda van Leeuwen, Daniel G. Miller
Journal: JNCI Journal of the National Cancer Institute (1961)

Antiserums were prepared against normal and leukemic granulocytes, against the white cells of acute leukemic patients, and against lymphocytes from patients with lymphocytic leukemia. With these antiserums several leukocyte antigens could be identified, and their distribution in various cells and organs was investigated. One of these antigens was highly specific for granulocytes; another could be found only in the leukocytes from certain patients with acute leukemia, as well as in several normal organ extracts. No antigen specific for the lymphocytes was found, but the lymphocytes from different patients varied in their content of several antigens. As yet it has not been possible to detect antigenic differences between normal granulocytes and those from patients with chronic myelogenous leukemia.
Original article. Molecular and immunological characterization of cytochrome c: a potential cross‐reactive allergen in fungi and grasses
Authors: V. Sharma, B. P. Singh, S. N. Gaur, N. Arora
Journal: Allergy (2008)

Background: Recombinant allergens are required for component‐resolved diagnosis/therapy of allergic disorders. The study was aimed to express and characterize an allergenic protein from Curvularia lunata and study its cross‐reactivity. Methods: A clone encoding a 12‐kDa protein screened from the cDNA library of C. lunata was sequenced and expressed in pET22b+ vector. The purified protein was characterized by biophysical and immunological methods. Results: The sequence of gene encoding a 12‐kDa protein showed homology to cytochrome c. It was expressed in Escherichia coli yielding 0.5 mg protein/l culture and designated as Cur l 3. The absorption and circular dichroism spectrum of Cur l 3 were similar to horse cytochrome c and the protein reacted with cytochrome c antibody. ELISA with different fungal‐positive patients’ sera showed ≥ 3 times specific IgE to Cur l 3 compared with healthy controls. Mice anti‐Cur l 3 reacted with tropical and temperate grass extracts. Protein also reacted with grass‐positive patients’ sera. In vitro stimulation of peripheral blood mononuclear cells from C. lunata , fungi or grass‐positive patients with it released significant levels of Th2 cytokines. In vivo testing of this protein in allergic patients showed marked positive skin reactivity in 60% fungal and 43% grass‐positive cases. Cross inhibition assays (EC 50 ) demonstrated allergenic cross‐reactivity of Cur l 3 with fungi and grasses. Conclusions: Cytochrome c, a major allergen from C. lunata was cloned, sequenced and expressed. It was identified as a cross‐reactive allergen among fungi and grasses and has potential for clinical application.
PNR-23SHH AND WNT SIGNALLING ARE UPREGULATED IN HUMAN INTRAOCULAR MEDULLOEPITHELIOMA AND LEAD TO RETINAL TUMOR-LIKE LESIONS IN THE MOUSE
Authors: Julia Dietlmeier, Andrey Korshunov, Harald Bartsch, Karl Sotlar, Jasmin Ohli, Ulrich Schüller, Julia Neumann
Journal: Neuro-Oncology (2016)
Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery
Authors: Jae-Young Lee, Ubonvan Termsarasab, Ju-Hwan Park, Song Yi Lee, Seung-Hak Ko, Jae-Seong Shim, Suk-Jae Chung, Hyun-Jong Cho, Dae-Duk Kim
Journal: Journal of Controlled Release (2016)
Prevention of Thrombosis in the Inferior Vena Cava
Authors: J O JUST-VIERA, G H YEAGER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Free and Combined Amino Acids in the Protein-Free Ultrafiltrates from Whole Chick-Embryo Extracts&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: B B WESTFALL, E V PEPPERS, W R EARLE
Journal: JNCI Journal of the National Cancer Institute (1954)

The Free and Combined Amino Acids in the Protein-Free Ultrafiltrates from Whole Chick-Embryo Extracts Get access Benton B. Westfall, Benton B. Westfall Tissue Culture Section, Laboratory of Biology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellison V. Peppers, Ellison V. Peppers Tissue Culture Section, Laboratory of Biology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle Wilton R. Earle Tissue Culture Section, Laboratory of Biology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 433–438, https://doi.org/10.1093/jnci/15.3.433 Published: 01 December 1954 Article history Received: 23 July 1953 Published: 01 December 1954