tbuckley/cabot-search huggingface dataset:
Bortezomib Plus Melphalan–Prednisone Continues to Demonstrate a Survival Benefit Vs Melphalan–Prednisone in the Phase III VISTA Trial in Previously Untreated Multiple Myeloma After 3 Years' Follow-up and Extensive Subsequent Therapy Use.
Authors: Maria-Victoria Mateos, Paul G Richardson, Rudolf Schlag, Nuriet K Khuageva, Meletios A. Dimopoulos, Ofer Shpilberg, Martin Kropff, Ivan Spicka, Maria Teresa Petrucci, Antonio Palumbo, Olga S Samoilova, Anna Dmoszynska, Kudrat M Abdulkadyrov, Rik Schots, Bin Jiang, Dixie-Lee Esseltine, Kevin Liu, Andrew Z Cakana, Helgi van de Velde, Jesús F. San Miguel
Journal: Blood (2009)
Mental retardation and "nontoxic" lead levels
Authors: O J David, G Grad, B U McGann, A Koltun
Journal: American Journal of Psychiatry (1982)

The authors studied the blood lead concentrations of children with IQs of 55-84, divided according to the presence (N = 48) or absence (N = 35) of a probable etiology for their retardation, and of 40 control children. The mean lead level of the retarded children with unknown etiologies was 25.03 micrograms/dl, which was significantly higher than those of the other two groups; 54% of the group with unknown etiologies had levels above 25 micrograms/dl, compared with 15% of the retarded children with probable etiologies and 17% of the control children. In the group of retarded children with unknown etiologies there was a significant negative correlation between lead levels and IQ.
Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer
Authors: Jian Wang, Shouhui Yang, Peijun He, Aaron J. Schetter, Jochen Gaedcke, B. Michael Ghadimi, Thomas Ried, Harris G. Yfantis, Dong H. Lee, Matthias M. Gaida, Nader Hanna, H. Richard Alexander, S. Perwez Hussain
Journal: Clinical Cancer Research (2016)

Pancreatic ductal adenocarcinoma (PDAC) is refractory to available treatments. Delineating critical pathways, responsible for disease aggressiveness and therapeutic resistance, may identify effective therapeutic targets. We aimed to identify key pathways contributing to disease aggressiveness by comparing gene expression profiles of tumors from early-stage PDAC cases with extremely poor survival (≤7 months) and those surviving 2 years or more following surgical resection.Gene expression profiling was performed in tumors in a test cohort of PDAC (N = 50), which included short (≤7 months, N = 11) and long surviving (≥2 years, N = 14) patients, using affymetrix GeneChip Human 1.0 ST array. Key genes associated with disease aggressiveness were identified, using Cox regression, Kaplan-Meier, and pathway analyses with validations in independent cohorts for mechanistic and functional analyses.Gene expression profiling identified 1,820 differentially expressed genes between short and long survival groups with inflammatory gene network ranking first. Lower expression of endothelial nitric oxide synthase traffic inducer (NOSTRIN) was associated with worst survival indicating its potential inhibitory role in disease progression. NOSTRIN overexpression suppressed migration and invasion of pancreatic cancer cells and enhanced sensitivity to chemotherapeutic drug gemcitabine. NOSTRIN inhibited production of nitric oxide (NO) by suppressing the activation of endothelial nitric oxide synthase (eNOS). Furthermore, miR-221, bound to the 3'UTR of NOSTRIN and suppressed its expression, and an increased miR-221 expression associated with poor survival in PDAC.Our findings showed that NOSTRIN is a potential negative regulator of disease aggressiveness, which may be targeted for designing improved treatment strategy in PDAC. Clin Cancer Res; 22(24); 5992-6001. ©2016 AACR.
Sucralose Promotes Food Intake through NPY and a Neuronal Fasting Response
Authors: Qiao-Ping Wang, Yong Qi Lin, Lei Zhang, Yana A. Wilson, Lisa J. Oyston, James Cotterell, Yue Qi, Thang M. Khuong, Noman Bakhshi, Yoann Planchenault, Duncan T. Browman, Man Tat Lau, Tiffany A. Cole, Adam C.N. Wong, Stephen J. Simpson, Adam R. Cole, Josef M. Penninger, Herbert Herzog, G. Gregory Neely
Journal: Cell Metabolism (2016)
ADA-SCID Gene Therapy Endorsed By European Medicines Agency For Marketing Authorization
Authors: Seppo Ylä-Herttuala
Journal: Molecular Therapy (2016)

The Committee for Human Medicinal Products has recently recommended marketing authorization for retrovirus-mediated ex vivo gene therapy of patients' autologous CD34+ cells transduced with human ADA complementary DNA for the treatment of adenosine deaminase severe combined immunodeficiency (ADA-SCID).1 If confirmed by the European Commission, the product, called Strimvelis, would be the third approved gene therapy in the European Union. According to the CHMP opinion, "Strimvelis is indicated for the treatment of patients with severe combined immune deficiency due to ADA deficiency (ADA-SCID), for whom no suitable matched related stem cell donor is available." The positive opinion includes a request to establish a post-treatment registry and long-term follow-up of the patients.
Adalimumab long-term safety: infections, vaccination response and pregnancy outcomes in patients with rheumatoid arthritis
Authors: Gerd R Burmester, Robert Landewé, Mark C Genovese, Alan W Friedman, Nathan D Pfeifer, Nupun A Varothai, Ana P Lacerda
Journal: Annals of the Rheumatic Diseases (2016)

Background Adalimumab has been used in patients with moderately to severely active rheumatoid arthritis (RA) for over 10 years and has a well-established safety profile across multiple indications. Objective To update adverse events (AEs) of special interest from global adalimumab clinical trials in patients with RA. Methods This analysis includes 15 132 patients exposed to adalimumab in global RA clinical trials. AEs of interest included overall infections, laboratory abnormalities and AEs associated with influenza vaccination. Pregnancy outcome data were collected from the Adalimumab Pregnancy Registry. Results Serious infections and tuberculosis occurred at a rate of 4.7 and 0.3 events/100 patient-years, respectively. Two patients experienced hepatitis B reactivation. No significant laboratory abnormalities were reported with adalimumab-plus-methotrexate compared with placebo-plus-methotrexate. Influenza-related AEs occurred in 5% of vaccinated patients compared with 14% of patients not vaccinated during the study. Relative risk of major birth defects and spontaneous abortions in adalimumab-exposed women were similar between that of unexposed women with RA and healthy women. Conclusions This analysis confirms and expands the known safety profile of adalimumab and reports no additional safety risk of laboratory abnormalities, hepatitis B reactivation and pregnancy outcomes, including spontaneous abortions and birth defects. The benefits of influenza vaccination are reinforced. Trial registration numbers NCT00195663, NCT00195702 , NCT00448383 , NCT00049751 , NCT00234845 , NCT00650390 , NCT00235859 , NCT00647920 , NCT00649545 , NCT00647491 , NCT00649922 , NCT00538902 , NCT00420927 , NCT00870467 , NCT00650156 , NCT00647270 , NCT01185288 , NCT01185301 .
Oral HPV-Associated Papillomatosis in AIDS
Authors: Jacobo Limeres Posse, Crispian Scully
Journal: New England Journal of Medicine (2016)

A 36-year-old man who had AIDS with Kaposi's sarcoma was referred for evaluation of extensive, painless oral papillomatous lesions. His history included sex with men, and his partner had a history of anogenital warts. The patient was receiving highly active antiretroviral therapy.
The Outcome of Unselected Patients with Chronic Myeloid Leukemia (CML) In Chronic Phase (CP) Treated with Imatinib In the First Line and the Prognostic Value of ELN Defined Responses – Population Based Analysis of 458 Patients Treated Between 2003–2009.
Authors: Hana Klamova, Daniela Zackova, Edgar Faber, Katerina Steinerova, Michal Karas, Eva Demeckova, Jaroslava Voglova, Ludmila Demitrovicova, Elena Tothova, Juraj Chudej, Imrich Markuljak, Tomas Kozak, Eduard Cmunt, Marie Jarosova, Katerina Machova-Polakova, Kyra Michalova, Ladislav Dusek, Jan Muzik, Martin Mistrik, Jiri Mayer, Marek Trneny, Karel Indrak
Journal: Blood (2010)
Prevention of transmission of HIV, hepatitis B virus, hepatitis C virus, and tuberculosis in prisoners
Authors: Adeeba Kamarulzaman, Stewart E Reid, Amee Schwitters, Lucas Wiessing, Nabila El-Bassel, Kate Dolan, Babak Moazen, Andrea L Wirtz, Annette Verster, Frederick L Altice
Journal: The Lancet (2016)
Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell–derived lymphomas
Authors: David Vallois, Maria Pamela D. Dobay, Ryan D. Morin, François Lemonnier, Edoardo Missiaglia, Mélanie Juilland, Justyna Iwaszkiewicz, Virginie Fataccioli, Bettina Bisig, Annalisa Roberti, Jasleen Grewal, Julie Bruneau, Bettina Fabiani, Antoine Martin, Christophe Bonnet, Olivier Michielin, Jean-Philippe Jais, Martin Figeac, Olivier A. Bernard, Mauro Delorenzi, Corinne Haioun, Olivier Tournilhac, Margot Thome, Randy D. Gascoyne, Philippe Gaulard, Laurence de Leval
Journal: Blood (2016)
Occurrence of Pulmonary Tumors in Mice of Strains A, BL, and SWR and Their F&lt;sub&gt;1&lt;/sub&gt; Hybrids Following Intravenous Injection of 1,2,5,6-Dibenzanthracene&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Deringer, Margaret K., Heston, W. E.
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Occurrence of Pulmonary Tumors in Mice of Strains A, BL, and SWR and Their F1 Hybrids Following Intravenous Injection of 1,2,5,6-Dibenzanthracene Get access Margaret K. Deringer, Margaret K. Deringer National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Heston W. E. Heston National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 1, August 1953, Pages 127–130, https://doi.org/10.1093/jnci/14.1.127 Published: 01 August 1953 Article history Received: 27 February 1953 Published: 01 August 1953
Ratings of videotaped simulated patient interviews and four other methods of evaluating a psychiatry clerkship
Authors: E Mumford, H Schlesinger, T Cuerdon, J Scully
Journal: American Journal of Psychiatry (1987)

Ratings of videotaped interviews with simulated patients were compared with four other measures commonly used to evaluate medical students during their psychiatry clerkship. Intercorrelations among self-reported attitude change, written examination grade, and student rating of satisfaction with the clerkship suggest that each measures different processes. Low but significant correlations between preceptor ratings of interaction skills and data-gathering skills and process and content scores based on an end-of-course videotaped interview suggest that preceptor ratings and the videotaped interview method evaluated the same skills. The authors conclude that preceptor evaluations supplemented by objective ratings of videotaped interviews show promise for evaluating the development of interviewing skills.
PD-037 The relationship of high neutrophil-to-lymphocyte ratio to disease-free survival in colorectal cancer
Authors: A. Mouchli Mohamad, S. Rashtak, X. Ruan, H. Liu, J. Washechek Aletto, A. Johnson Ruth, R. Druliner Brooke, D. Felmlee Devine, L. Boardman
Journal: Annals of Oncology (2016)
Identification of the Leukemia-Specific Domains of the CALM/AF10 Fusion Gene, a Product of the Leukemia Associated T(10;11) Translocation.
Authors: Aniruddha J Deshpande, Natalia Arseni, Yihui Lin, Guoliang Xu, Wolfgang Hiddemann, Stefan Bohlander, Michaela Feuring-Buske, Christian Buske
Journal: Blood (2008)
Prognostic value of a 46-gene cell cycle progression (CCP) RNA signature for prostate cancer death in a conservatively managed watchful waiting needle biopsy cohort.
Authors: J. M. Cuzick, G. Fisher, D. Berney, D. Mesher, H. Møller, J. E. Reid, A. Gutin, J. S. Lanchbury, S. Stone
Journal: Journal of Clinical Oncology (2011)

4542 Background: The natural history of newly diagnosed prostate cancer is highly variable and difficult to predict accurately. Improved tools are needed to more appropriately match treatment to a patient’s risk of progression. We previously showed that a 46 gene cell cycle progression (CCP) RNA signature is a robust predictor of biochemical recurrence after radical prostatectomy and of prostate cancer-specific death in a conservatively managed cohort diagnosed by transurethral resection of the prostate. However, the greatest need exists for predicting outcome in patients diagnosed by needle biopsy. Here we report the utility of the CCP score obtained from a needle biopsy in a cohort of conservatively managed watchful waiting patients. Methods: mRNA was extracted from paraffin embedded needle biopsies from UK men diagnosed with clinically localized prostate cancer between 1990 and 1996. RNA levels of 46 genes were determined and a mean composite score calculated (CCP score) for each patient. Clinical variables consisted of centrally re-reviewed Gleason score, baseline PSA, age, clinical stage, and extent of disease (proportion of positive cores). The primary endpoint was death from prostate cancer after a mean follow up of 9.8 yrs. Results: In univariate analysis (n=352), The hazard ratio (HR) for death for prostate cancer was 2.67 (95% CI (1.99,3.58), P =10-10) for a change from the 25th to 75th percentile of the CCP score. In a multivariate analysis (n=333) which included Gleason and PSA, CCP dominated (HR for change from 25th to 75th percentile = 2.07, 95% CI(1.50, 2.85) χ2= 20.8, , P = 5 x 10-6) with only Gleason score providing a significant, additional contribution (χ2= 15, 1df, P = 0.0001) and baseline PSA was nonsignificant (χ2 = 1.6). Conclusions: For patients managed by active surveillance, the CCP score is the strongest predictor of cancer death outcome yet described. The additional independent prognostic information offered by this RNA assay may be valuable in the management of prostate cancer.
Prevalence of risk factors for heart disease in OXCHECK trial: Implications for screening in primary care
Authors: A. Coulter, G. Fowler, L. Jones, M. Lawrence, D. Mant, J. Muir, A. Neil, L. Roe, N. Rusted, T. Schofield, M. Thorogood, P. Yudkin
Journal: BMJ (1991)

Objective - To describe the outcome of offering health checks systematically to a general practice adult population, in terms of age and sex specific prevlance of risk factors, follow up workload, and selective screening of cholesterol concentration. Design - Descriptive analysis of data obtained by postal questionnaire and by personal interview and clinical examination by a trained nurse. Subjects - 2205 patients aged 35-64 who attended for a health check in 1989-90 from an invited random sample of 2777 patients from five urban general practices in Bedfordshire. Results - Overall, almost three quarters of patients (78% of men, 68% of women) needed specific advice or follow up. Smoking, a high fat diet, and being overweight (body mass index ≥25 kg/m2) were common characteristics exhibited by 35%, 31%, and 55% respectively of men and 24%, 18%, and 48% of women. The total cholesterol concentration was ≥6.5 mmol/l in 37% of patients and ≥8mmol/l in 8%. In terms of workload 13% needed dietary advice only, 15% needed only follow up of hyperlipidaemia or hypertension, and 9% needed advice on smoking only. A further 35% needed follow up for a combination of risk factors. The proporation of patients in whom cholesterol concentration would be measured if a selective screening policy were adopted would vary from 29% to 71%, according to different criteria, but (particularly in men) no combination would be much better than random testing as a means to detect patients with a total cholesterol concentration ≥8 mmol/l. Conclusions - If the entire adult popualtion of a practice is offered health checks systematically the acceptance rate is lower and the follow up workload higher than previously understood. The resource implications depend on the age and sex of patients screened and the selective criteria adopted for cholesterol measurement. Health checks are only the beginning of a successful preventive programme - the challenge is to provide effective intervention and follow up.
The Biotherapeutic Action of &lt;italic&gt;Trypanosoma cruzi&lt;/italic&gt; on Tar Carcinoma in Mice
Authors: G C JEDELOO, G O E LIGNAC, A J LIGTENBERG, P H van THIEL
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article The Biotherapeutic Action of Trypanosoma cruzi on Tar Carcinoma in Mice Get access G. C. Jedeloo, G. C. Jedeloo Search for other works by this author on: Oxford Academic PubMed Google Scholar G. O. E. Lignac, G. O. E. Lignac Search for other works by this author on: Oxford Academic PubMed Google Scholar A. J. Ligtenberg, A. J. Ligtenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar P. H. van Thiel P. H. van Thiel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 4, February 1950, Pages 809–813, https://doi.org/10.1093/jnci/10.4.809 Published: 01 February 1950 Article history Received: 24 June 1949 Published: 01 February 1950
Independence day?
Authors: Nigel Hawkes
Journal: BMJ (2007)

oliticians seldom admit that their presence may not be strictly nec essary.But the debate over NHS independence, launched in the BMJ in 2006, has inspired some soul searching.Has political meddling held back progress or interfered with the ability of medical professionals to deliver the best possible service for the money?Might an independent NHS, shorn of day to day man agement by ministers, work more smoothly and harmoniously?Among those in favour of the proposition are David Cameron and Andrew Lansley of the Conservative party, the Council of the BMA, policy
A 3-gene expression score as prognostic factor in triple negative and basal breast tumors with residual disease.
Authors: Joseph A. Pinto, Jhajaira Araujo, Nadezhda K Cardenas, Justin M. Balko, Carlos L. Arteaga, Henry Gomez
Journal: Journal of Clinical Oncology (2015)

1097 Background: Residual disease after neoadjuvant chemotherapy (NAC) in triple negative breast cancer (TNBC) represents poor prognosis. Identification of genes involved in prognosis could lead to a better stratification of patients and better design of therapeutic strategies. Our aim was to identify gene signatures related to the recurrence free survival (RFS) in this subset of patients. Methods: We quantified expression for 450 genes by Nanostring in 82 triple negative residual tumors after NAC (discovery group). Levels of gene expression were normalized to spike controls then log2 transformed and median centered. The validation group consisted in 117 basal breast tumors with residual disease (from the public dataset GSE25066) profiled with the U133A microarray. Samples in this dataset were evaluated before NAC. Results: An univariate Cox regression identify 7 genes significantly related with the RFS (CCL5, CYBB, DDIT4, GTPBP4, KRT6B, PALMD and POLR1C). A stepwise multivariate analysis selected to CCL5, DDIT4 and POLR1C as independent factors for RFS. Using the regression coefficient for each gene we constructed a score (-0.393*CCL5 + 0.443*DDIT4 + 0.490*POLR1C). The median of score was 0.1494. The CoxPH show an HR = 2.72 per unit of change (P < 0.001; CI95%: 1.72-4.28). The median score in the validation set was -0.036 and the score was significant related with the RFS with an HR = 15.86 per unit of change (P < 0.045; CI95%: 1.06-237.11). Using the logrank test and the median scores as cutoff (for each group), it was possible identifies two subgroups with different RFS (P < 0.001 in the discovery group and P < 0.003 in the validation group). Conclusions: We could identify a prognostic score based in CCL5, DDIT4 and POLR1C expression related with the recurrence free survival. A deep evaluation of the molecular mechanisms of these genes in resistance to chemotherapy should be done.
Antithrombotic Treatment and Outcomes of Splanchnic Vein Thrombosis in an International Prospective Registry: Results of 2-Year Follow-up
Authors: Walter Ageno, Nicoletta Riva, Sam Schulman, Jan Beyer-Westendorf, Soo-Mee Bang, Marco Senzolo, Elvira Grandone, Giovanni Barillari, Matteo Di Minno, Rita Duce, Alessandra Malato, Rita Santoro, Daniela Poli, Peter Verhamme, Ida Martinelli, Pieter W. Kamphuisen, Francesco Dentali
Journal: Blood (2014)
Case 16-1984
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Richard M. Rose, Robert Fienberg
Journal: New England Journal of Medicine (1984)

Presentation of CaseA 37-year-old man was admitted to the hospital because of a pulmonary mass.There was a long history of paranoid schizophrenia, with repeated admissions to psychiatric hospitals. Six months before admission a chronic cough developed and was intermittently productive of blood. Three weeks before entry the patient began to complain of pain in the knees, shins, and heels. An x-ray film of the chest showed a pulmonary mass. He was admitted to the hospital.The patient smoked two to three packs of cigarettes daily for 20 years. He lost 9 kg in weight during the year before . . .
Effects of Prasugrel Versus Clopidogrel on Coronary Microvascular Function in Patients Undergoing Elective PCI
Authors: Fabio Mangiacapra, Giuseppe Di Gioia, Mariano Pellicano, Luigi Di Serafino, Edoardo Bressi, Aaron J. Peace, Jozef Bartunek, William Wijns, Bernard De Bruyne, Emanuele Barbato
Journal: Journal of the American College of Cardiology (2016)
T-Prolymphocytic Leukemia Is Sensitive to Polyclonal T Cell-Derived Graft-Versus-Leukemia Effects: Evidence from Minimal Residual Disease Kinetics and TCR Repertoire Diversity Analyses
Authors: Leopold Sellner, Peter Dreger, Max Schlitt, Henrik Knecht, Dietrich Herrmann, Thomas Reigl, Adam Krejci, Vojtech Bystry, Nikos Darzentas, Michael Rieger, Sascha Dietrich, Thorsten Zenz, Anthony D. Ho, Michael Kneba, Monika Brueggemann
Journal: Blood (2015)
Prednisone for Chronic Obstructive Pulmonary Disease
Authors: Giovanni Rolla, Caterina Bucca
Journal: New England Journal of Medicine (2003)

because of concern about the study design and statistical analysis. Aaron et al. state that prednisone significantly reduced the rate of relapse at 30 days (27 percent, vs. 43 percent with placebo; P=0.05) and that the relative risk of relapse after prednisone therapy was 0.63 (95 percent confidence interval, 0.40 to 1.01). We believe that these statements are misleading, given that the P value is 0.05 and that the 95 percent confidence interval for the relative risk includes 1.0 and therefore is not statistically significant. We are also concerned about the use of a t-test to analyze scores on the Chronic Respiratory Disease Index Questionnaire and transitional dyspnea index, which yield ordinal, not continuous, data. 2 Since the primary outcome was not statistically significant, we also believe that a power analysis should have been conducted and considered when the results were interpreted. 3
Preventing and controlling tuberculosis among refugees in Europe: more needed for high-risk populations
Authors: Gerard de Vries, Job van Rest, Wieneke Meijer, Bert Wolters, Rob van Hest, Michael Kimerling
Journal: European Respiratory Journal (2016)

We thank M. Dara and colleagues for their commentary on our article "Low yield of screening asylum seekers from countries with a tuberculosis (TB) incidence of <50 per 100 000 population" [1]. We agree that the current high influx of refugees from both low- and high-incidence countries into countries that already have a TB incidence <10 per 100 000 population, e.g. many European Union member states, brings up a number of new challenges. Screening asylum seekers from high TB incidence countries for LTBI is recommended in low-incidence countries <http://ow.ly/4nbKhU>