tbuckley/cabot-search huggingface dataset:
AB0945 An Atlas Based Automatic Segmentation of The Human Thigh Muscles: A Promising Approach for Muscle Volume Quantification in Longitudinal Studies
Authors: A. Le Troter, A. Fouré, M. Guye, S. Confort-Gouny, J.-P. Mattei, S. Guis, J. Gondin, E. Salort-Campana, D. Bendahan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Atlas segmentation is a powerful method for automatic structural segmentation of several sub-structures in many organs. However, so far, very few studies have assessed this method for skeletal muscle segmentation. <h3>Objectives</h3> In this study, we present an atlas-based pipeline we have developed for segmentation of quadriceps muscles from magnetic resonance images obtained in twenty five young healthy males and illustrate the potential of this approach for a longitudinal follow-up in a group of 7 subjects. <h3>Methods</h3> T1-weighted axial MR images from the thigh were recorded once in a group of 25 subjects (G1) and twice (a few days apart) in another group of 7 subjects (G2). The multi-atlas library was built from G1. In order to do so, MR images were initially automatically segmented for bone, muscle and fat tissues and each muscle of the thigh anterior compartment was manually delineated. The same process was applied to G2 in order to obtain the ground-truth set of images. Then each MRI dataset from G1 was registered to each MRI dataset of G2 using a non-linear registration process. An optimal fusion method was then used applied in order to obtain the highest DICE index, a similarity index between the atlas-based manual segmentation and the ground-truth set of images. A single-atlas version of the pipeline was used without the fusion process and a similar validation was performed for a longitudinal follow-up study. <h3>Results</h3> In control subjects, the results for each quadriceps muscle show a mean DICE similarity coefficient higher than 0.85. While the multi-atlas pipeline did not provide sensitive enough for muscle volume quantification, the single-atlas version proved to be far better. <h3>Conclusions</h3> In the present study we reported two segmentation pipelines based on atlases. The examples provided in a control population demonstrated a robust method which could be useful for muscle quantification in the fields of neuromuscular disorders, sports medicine and rehabilitation. <h3>Disclosure of Interest</h3> None declared
Prognostic Significance of Circulating Lymphoma Cells in Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL).
Authors: Disni Muringampurath-John, Christopher R. Flowers, Adnan A Jabbar, Rajni Sinha, Martha Arellano, Leon Bernal-Mizrachi, Jonathan L. Kaufman, David L. Jaye, Zhengjia Chen, Mary Jo Lechowicz, Sagar Lonial, James O. Armitage, H. Jean Khoury
Journal: Blood (2009)
OC-031 A Genome-Wide Association Study Identifies PNPLA3 and SLC38A4 as Risk Loci for Alcoholic Hepatitis
Authors: S Atkinson, M Way, A McQuillin, MY Morgan, M Thursz
Journal: Gut (2016)

<h3>Introduction</h3> The clinical spectrum of alcohol-related liver disease varies widely but the majority of patients with evolving disease are asymptomatic. However, a small minority of patients develop severe alcoholic hepatitis (SAH), a clinical syndrome manifest as profound hepatocellular failure, often superimposed on cirrhosis. As only a relative minority of patients develop SAH genetic determination of susceptibility has been proposed. A genome-wide association study (GWAS) approach was used to identify potential risk loci for SAH. <h3>Methods</h3> Cases with SAH, of self-reported white British ancestry, were recruited prospectively through the Steroids or Pentoxifylline for Alcoholic Hepatitis trial (n = 860). Ancestry-matched controls with alcohol dependence but without alcohol-related liver injury were recruited from the Centre for Hepatology, Royal Free Hospital, London (n = 1191). A two-stage GWAS was performed. DNA samples from an exploratory cohort (332 cases, 318 controls) were genotyped on Illumina CoreExome BeadChips (Illumina, San Diego, USA) at the Wellcome Trust Sanger Institute, Cambridge, UK. The most significantly associated SNPs were genotyped in DNA samples from an independent replication cohort (528 cases, 873 controls) using KASPar chemistry (LGC Genomics, Hoddesdon, UK). Data were analysed in PLINK1.9. <h3>Results</h3> The variant rs738409 in patatin-like phospholipase domain-containing protein 3 (<i>PNPLA3) </i>was associated at genome-wide significance level (P<sub>THRESHOLD</sub> &lt;5x10<sup>−8</sup>; P<sub>EXPLORATORY</sub> =1.619x10<sup>−8</sup>, OR 2.21 [95% CI 1.68–2.91]). Ten additional, independent loci demonstrated suggestive association (P<sub>THRESHOLD</sub> &lt;1.1x10<sup>−5</sup>). Replication genotyping for the lead markers at each locus demonstrated disease association for rs738409 in <i>PNPLA3</i> (P<sub>REPLICATION</sub> = 3.47x10<sup>−8</sup>; P<sub>META</sub> = 8.62x10<sup>−15</sup>; OR 1.87) and Solute Carrier Family 38, Member 4 (<i>SLC38A4)</i> (P<sub>REPLICATION</sub> = 0.029; P<sub>META</sub> = 4.13x10<sup>−5</sup>; OR 1.32). <h3>Conclusion</h3> This first analysis of data from a GWAS of severe alcoholic hepatitis confirms significant risk association with <i>PNPLA3,</i> consistent with the phenotypic overlap with alcohol-related cirrhosis. It also identified <i>SLC38A4</i> as a potential, novel risk locus for development of alcoholic hepatitis <i>per se</i>; this gene is predominantly expressed in the liver and is involved in amino acid transport. <h3>Disclosure of Interest</h3> None Declared
Epstein-Barr Virus Infection Is Not the Sole Cause of High Prevalence for Hodgkin’s Lymphoma in Saudi Arabia.
Authors: Khawla S. Al-Kuraya, Rajeswari Narayanappa, Fouad Al-Dayel, Hassan El-Solh, Adnan Ezzat, Hoda Ismail, Asim Belgaumi, Valerie Atizado, Kishor Bhatia, Guido Sauter, Ronald Simon
Journal: Blood (2004)
Glucocorticoids Inhibit Cell Death Induced by Oncogenic Stress After Imatinib Withdrawal In TKI Resistant p190Bcr/Abl Overexpressing Cells
Authors: Michael A. Dengler, Annette M. Staiger, Ute Hofmann, Matthias Gutekunst, Heiko van der Kuip, Walter E. Aulitzky
Journal: Blood (2010)
Superiority of Lenalidomide (Len) Plus High-Dose Dexamethasone (HD) Compared to HD Alone as Treatment of Newly-Diagnosed Multiple Myeloma (NDMM): Results of the Randomized, Double-Blinded, Placebo-Controlled SWOG Trial S0232.
Authors: Jeffrey A. Zonder, John Crowley, Mohamad A. Hussein, Vanessa Bolejack, Dennis F. Moore, Brock F. Whittenberger, Muneer H. Abidi, Brian G.M. Durie, Bart Barlogie
Journal: Blood (2007)
BRD4 Antagonist and Histone Deacetylase Inhibitor: A Novel Synergistic Combination Against Human Acute Myeloid Leukemia (AML) Cells
Authors: Warren Fiskus, Sunil Sharma, Jun Qi, John A Valenta, Leasha J Schaub, Bhavin Shah, Karissa Peth, Laxmi U.M.R. Jakkula, Melissa Rodriguez, Santhana Devaraj, Swaminathan Padmanabhan Iyer, James E Bradner, Kapil N. Bhalla
Journal: Blood (2013)
A quiet corner room
Authors: Jenna Gantner
Journal: BMJ (2016)

A 23 year old woman walks into an emergency department. She's 22 weeks pregnant, and she can't breathe. Her doctor mumbles something reassuring as her mind pours over differentials and her hand passes an ET tube. The patient teeters on this moment, and the room takes a deep breath.

The 23 year old has gone from a person to a body that doctors try to …
XmAb®5592 Fc-Engineered Humanized Anti-HM1.24 Monoclonal Antibody Has Potent in Vitro and In Vivo Efficacy against Multiple Myeloma.
Authors: Yu-Tzu Tai, Umesh Muchhal, Xian-Feng Li, Sabikun Nahar, Weihua Song, Holly Horton, Hanh Nguyen, Sher Karki, John Desjarlais, Nikhil C. Munshi, Paul Richardson, Kenneth C. Anderson
Journal: Blood (2009)
Role of Platelet-Derived Growth Factor On Vascular Endothelial Growth Factor Synthesis by Mesenchymal Stem Cells in Chronic Lymphocytic Leukemia: Implications for Clinical Progression.
Authors: Wei Ding, Traci Knox, Susan Schwager, Charla Secreto, Asish K Ghosh, Wenting Wu, Neil E. Kay
Journal: Blood (2009)
Breast Milk from Immune Thrombocytopenic Mothers Can Contain Anti Platelet Antibodies That Are Associated with Persistent Thrombocytopenia in Neonates
Authors: Nehama Sharon, Nurit Rosenberg, Uri Seligsohn, Aryeh Simmonds, Yakov Shiff, Yaakov Schechter, Hagit Hausner
Journal: Blood (2014)
5HPP-33, a Novel Tubulin-Polymerization Inhibitor Derived from Thalidomide, Directly Inhibits Proliferation and Induces Apoptosis of Human Multiple Myeloma Cells.
Authors: Toyotaka Iguchi, Sawako Oda-Nakazato, Tomomi Noguchi, Yuichi Hashimoto, Yutaka Hattori, Taketo Yamada, Yasuo Ikeda, Masahiro Kizaki
Journal: Blood (2005)
Yes‐associated protein/TEA domain family member and hepatocyte nuclear factor 4‐alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice
Authors: Wang‐Yu Cai, Ling‐Yun Lin, Han Hao, Sai‐Man Zhang, Fei Ma, Xin‐Xin Hong, Hui Zhang, Qing‐Feng Liu, Guo‐Dong Ye, Guang‐Bin Sun, Yun‐Jia Liu, Sheng‐Nan Li, Yuan‐Yuan Xie, Jian‐Chun Cai, Bo‐An Li
Journal: Hepatology (2016)

Great progress has been achieved in the study of Hippo signaling in regulating tumorigenesis; however, the downstream molecular events that mediate this process have not been completely defined. Moreover, regulation of Hippo signaling during tumorigenesis in hepatocellular carcinoma (HCC) remains largely unknown. In the present study, we systematically investigated the relationship between Yes‐associated protein/TEA domain family member (YAP‐TEAD) and hepatocyte nuclear factor 4‐alpha (HNF4α) in the hepatocarcinogenesis of HCC cells. Our results indicated that HNF4α expression was negatively regulated by YAP1 in HCC cells by a ubiquitin proteasome pathway. By contrast, HNF4α was found to directly associate with TEAD4 to compete with YAP1 for binding to TEAD4, thus inhibiting the transcriptional activity of YAP‐TEAD and expression of their target genes. Moreover, overexpression of HNF4α was found to significantly compromise YAP‐TEAD‐induced HCC cell proliferation and stem cell expansion. Finally, we documented the regulatory mechanism between YAP‐TEAD and HNF4α in rat and mouse tumor models, which confirmed our in vitro results. Conclusion : There is a double‐negative feedback mechanism that controls TEAD‐YAP and HNF4α expression in vitro and in vivo , thereby regulating cellular proliferation and differentiation. Given that YAP acts as a dominant oncogene in HCC and plays a crucial role in stem cell homeostasis and tissue regeneration, manipulating the interaction between YAP, TEADs, and HNF4α may provide a new approach for HCC treatment and regenerative medicine. (H epatology 2017;65:1206‐1221).
AB0904 Pericarditis as A Possible Predictor for Biological Disease Modifying Anti-Rheumatic Drugs Need in Adult Onset Still's Disease
Authors: F. Dall'ara, M. Frassi, A. Tincani, P. Airò
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Adult onset Still9s disease (AOSD) is a rare systemic inflammatory disorder of unknown aetiology, which is considered to be similar to systemic-onset juvenile idiopathic arthritis (SOJIA). Peculiar clinical and laboratory features of SOJIA and AOSD led some authors to propose that these diseases should be included among the family of autoinflammatory diseases related to abnormalities in innate immune system. The optimal treatment strategy of AOSD is difficult to determine because of the absence of large-scale prospective studies. Predictive factors of outcome would be useful to draw guidelines for patient management. <h3>Objectives</h3> To look for clinical or serological markers able to predict the use of biological disease modifying anti-rheumatic drugs (bDMARDs) in patients with AOSD. To evaluate the efficacy and safety of bDMARDs in AOSD. <h3>Methods</h3> In a single-center retrospective study, 42 patients with AOSD were divided into two groups according to whether they were ever treated with bDMARDs (n:20) or not (n:22). Literature was searched for articles dealing with possible predictors of the use of bDMARDs in AOSD. <h3>Results</h3> Among 20 AOSD patients who received at least one bDMARDs, the prevalence of pericarditis was higher than in the other patients (8/20 vs 1/22; p:0.008; OR, 14.0, 95% CI 1.56 to 126). Literature search retrieved another paper dealing with predictors of bDMARDs need in AOSD (1): the analysis pooling data from our series and literature confirmed pericarditis at disease onset as a predictor of bDMARDs need (p:0.018; OR, 3.81, 95% CI 1.31 to 11.1). A complete remission was observed in 17 out of 18 evaluable patients treated with bDMARDs, allowing withdrawal or tapering of corticosteroid therapy (p&lt;0.001), but, because of inefficacy or adverse events, some patients received more than one bDMARD during the course of the disease, and 33 different trials of bDMARDs were needed. <h3>Conclusions</h3> Pericarditis is a possible marker of the auto-inflammatory process that may underlie the pathogenesis of AOSD. Pericarditis at disease onset may be a predictor of bDMARDs need. Biological DMARDs have a good efficacy and safety profile in AOSD, and should be considered for patients not responding to conventional therapy. <h3>References</h3> Quartuccio L, et al. Clin Exp Rheumatol 2012;30:807. <h3>Disclosure of Interest</h3> None declared
Quebec Platelet Disorder Is Caused by a Cis-Acting Mutation near the Plasminogen Activator Gene (PLAU) That Increases PLAU Transcription by Megakaryocytes.
Authors: Maria Diamandis, Andrew D Paterson, Johanna M Rommens, D. Kika Veljkovic, Jessica Blavignac, John S Waye, Francine Derome, Georges E. Rivard, Catherine PM Hayward
Journal: Blood (2008)
Senp1 drives hypoxia-induced polycythemia via GATA1 and Bcl-xL in subjects with Monge’s disease
Authors: Priti Azad, Huiwen W. Zhao, Pedro J. Cabrales, Roy Ronen, Dan Zhou, Orit Poulsen, Otto Appenzeller, Yu Hsin Hsiao, Vineet Bafna, Gabriel G. Haddad
Journal: The Journal of Experimental Medicine (2016)

In this study, because excessive polycythemia is a predominant trait in some high-altitude dwellers (chronic mountain sickness [CMS] or Monge’s disease) but not others living at the same altitude in the Andes, we took advantage of this human experiment of nature and used a combination of induced pluripotent stem cell technology, genomics, and molecular biology in this unique population to understand the molecular basis for hypoxia-induced excessive polycythemia. As compared with sea-level controls and non-CMS subjects who responded to hypoxia by increasing their RBCs modestly or not at all, respectively, CMS cells increased theirs remarkably (up to 60-fold). Although there was a switch from fetal to adult HgbA0 in all populations and a concomitant shift in oxygen binding, we found that CMS cells matured faster and had a higher efficiency and proliferative potential than non-CMS cells. We also established that SENP1 plays a critical role in the differential erythropoietic response of CMS and non-CMS subjects: we can convert the CMS phenotype into that of non-CMS and vice versa by altering SENP1 levels. We also demonstrated that GATA1 is an essential downstream target of SENP1 and that the differential expression and response of GATA1 and Bcl-xL are a key mechanism underlying CMS pathology.
OC-036 International Assessment of Outcome of Upper GI Haemorrhage at Weekends: Abstract OC-036 Table 1
Authors: IA Murray, HR Dalton, A Stanley, JH Ngu, B Maybin, M Eid, KG Madsen, R Abazi, H Ashraf, M Abdelrahim, R Lissmann, J Herrod, CJL Khor, HS Ong, DSC Koay, YK Chin, SB Laursen
Journal: Gut (2016)

<h3>Introduction</h3> Weekend admissions have been associated with higher mortality. For upper gastrointestinal haemorrhage (UGIH) some studies show significantly increased mortality and less early endoscopy while the UK UGIH audit reported no difference. We studied whether out of hours (OOH) admissions were sicker and/or had higher mortality. <h3>Methods</h3> Prospective study over 12 months (from March 2014) from 2 UK and 2 international centres. Admission time, demographics, pulse, BP, lab results, endoscopy findings, further procedures and 30 d mortality were recorded. 3 pre-endoscopy scores (Glasgow Blatchford (GBS), AIMS65 and admission Rockall scores) and 2 post-endoscopy scores (PNED and full Rockall scores) were determined. Chi-squared, Fisher’s exact and Kruskal-Wallis tests were used as appropriate. A two-tailed significance level of 5% was used. <h3>Results</h3> 2118 pconsecutive atients, 60% male, median age 66 years were seen. There were no significant differences in mortality, need for endoscopic therapy, surgery/embolisation or rebleeding in both UK and non-UK centres. There were no differences in comorbidity, mean ASA 2.3, pulse or BP although weekday admissions had a lower Hb (110 g/l vs 118 g/l (weeknight) vs 117 g/l (weekend) p &lt; 0.001 and higher GBS (p &lt; 0.05). No difference in peptic ulcer disease or varices incidence between periods although more weekday admissions had normal endoscopy (p = 0.002). OOH admissions were less likely to have an endoscopy (30% not endoscoped vs 23% for weekday admission p &lt; 0.005). Time to endoscopy was less for weeknight admissions (13 h vs 17 h for weekend and 20 h for weekday admissions p = 0.0001). 67% weekday, 75% weeknight and 60% weekend admissions had their endoscopy within 24 hours. 2118 consecutive patients admitted March 2014-March 2015 from Glasgow (600), Truro (544), Odense (541) and Singapore (433). Data shown are mean [95% CI] or number (%). <h3>Conclusion</h3> There is no difference in mortality in patients admitted with UGIH OOH compared to weekday admissions. The severity of UGIH was not related to time of admission. Similar findings were noted in the 2 UK centres and internationally. <h3>Disclosure of Interest</h3> None Declared
Diagnostic Challenges and Clinical Characteristics of Hepatitis E Virus–Associated Guillain-Barré Syndrome
Authors: Olivier Stevens, Kristl G. Claeys, Koen Poesen, Veroniek Saegeman, Philip Van Damme
Journal: JAMA Neurology (2016)

Hepatitis E virus (HEV) recently has been shown to be an antecedent infection in Guillain-Barré syndrome (GBS), but the clinical spectrum of HEV-associated GBS is not yet documented, and diagnosing acute HEV infection can be a challenge.To determine the prevalence of HEV-associated GBS in a Belgian cohort, study the clinical spectrum of HEV-associated GBS, and discuss difficulties in diagnosing acute HEV infection.This single-center, retrospective cohort study was conducted between January 1, 2007, and November 1, 2015. All patients with GBS or a GBS variant who presented to the adult neurology department of the University Hospital Leuven were identified via a search of the electronic medical records. Hepatitis E virus IgM and IgG reactivity was determined. In a subgroup, polymerase chain reaction for HEV was performed.Hepatitis E virus IgM and IgG reactivity.Of 73 eligible patients (mean [SD] age, 52 [18] years; 29 females and 44 males), 6 (8%) showed positive reactivity on IgM assays for HEV, indicating a possible acute HEV infection. Four of the 6 patients (67%) had increased alanine aminotransferase levels of more than 1.5 times the upper limit of normal, while 4 of 22 patients (18%) with increased alanine aminotransferase levels showed positive reactivity on HEV IgM assays. Serum samples of 2 of 6 patients with positive reactivity on HEV IgM assays also revealed positive test results for cytomegalovirus or Epstein-Barr virus, indicating possible cross-reactivity. Thus, 4 patients (6%) in our cohort had probable acute HEV infection. Two of these patients presented with an infrequent GBS variant.Acute HEV infection was frequently associated with GBS in our cohort. Abnormal alanine aminotransferase levels at admission can indicate the presence of an associated HEV infection. When HEV testing is considered, it is important to test for other infectious agents in parallel, as cross-reactivity can occur. Further studies are required to guide neurologists in their workup of underlying triggers of GBS.
Molecular Correlates of Anemia in Primary Myelofibrosis
Authors: Daniela Barraco, Terra L. Lasho, Kebede H. Begna, Naseema Gangat, Christy Finke, Curtis A. Hanson, Rhett P. Ketterling, Animesh Pardanani, Ayalew Tefferi
Journal: Blood (2015)
PTH-097 Outcome of Pregnancy in Patients with Known Budd-Chiari Syndrome
Authors: F Khan, I Rowe, D Tripathi, H Mehrzad, S Olliff, W Lester, F Chen, B Martin, E Knox, T Johnston, C Elliot
Journal: Gut (2016)

<h3>Introduction</h3> Budd–Chiari syndrome (BCS) is a rare disease that mainly affects young women. Pregnancy is a prothrombotic state which is likely to increase adverse outcome in patients with BCS. The aim is to study the outcome of pregnancy in patients with BCS to allow patients to understand the risks that may be associated. <h3>Methods</h3> A retrospective study of pregnancy in women with known and treated BCS at a single tertiary care centre from January 2001 to December 2015. <h3>Results</h3> Out of 53 females, seven women had 16 pregnancies. At least one causal factor for hepatic vein obstruction was identified in 6 women (86%). 6 women had undergone radiological decompressive treatment for BCS. All patients had anticoagulation and it was continued during all pregnancies. 6 foetuses were lost before 20 weeks gestation in 2 women. There were 9 deliveries over 32 weeks gestation and one delivery before 32 weeks (27 weeks of gestation). All infants did well. Seven patients needed emergency caesarean sections for different reasons. There were no cases of thrombosis. Two patients had noteworthy vaginal (PV) bleeding in three pregnancies. None of the patients had variceal haemorrhage. Two patients were diagnosed with pulmonary hypertension, one during pregnancy and the other in post-partum period. There was no maternal mortality. <h3>Conclusion</h3> Maternal outcome in patients with controlled BCS is generally good though majority of patients needed caesarean section. Fetal outcome beyond 20 weeks gestation is also good. Pregnancy should not be contraindicated in these patients and they should be managed in centres experienced in treating high-risk pregnancies with multi-disciplinary approach. Screening echocardiography to detect pulmonary hypertension should be considered in such patients. <h3>Disclosure of Interest</h3> None Declared
Biomarker Profiling of Bladder Cancer Patients Undergoing Radical Cystectomy. Relevance of Thrombotic and Inflammatory Processes
Authors: Schuharazad Abro, Melanie Clark, Marcus Quek, Omer Iqbal, Daniel Kahn, Debra Hoppensteadt, Josephine Cunanan, Jawed Fareed
Journal: Blood (2012)
Retherapy with Bendamustine-Containing Regimens in Patients with Relapsed/Refractory CLL and Indolent Lymphomas Achieves High Response Rates
Authors: Rudolf Weide, Stefan Feiten, Vera Friesenhahn, Jochen Heymanns, Kristina Kleboth, Jörg Thomalla, Christoph van Roye, Hubert Köppler
Journal: Blood (2011)