tbuckley/cabot-search huggingface dataset:
Alcoholism and its Treatment.
Authors: P A Lambert
Journal: JAMA (1893)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 17-1965
Authors: Roman W. DeSanctis, Benjamin Castleman
Journal: New England Journal of Medicine (1965)

Presentation of Case First admission. A thirty-nine-year-old real estate agent was admitted to the hospital because of a chronic cough.Nine years previously he had been informed that he had a heart murmur. He was asymptomatic until two and a half years before admission, when he became aware of unusual fatigue while sailing his boat. During the six months before entry he experienced exertional dyspnea and nocturnal wheezing. Three months before admission a respiratory infection developed, accompanied by a persistent cough productive of 4 oz. of thick, gray sputum daily.He smoked 2 packages of cigarettes and consumed 8 to . . .
A Note on the Selective Toxicity of Vincristine Sulfate on Chick-Embryo Sensory Ganglia in Tissue Culture2
Authors: José A. Burdman
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article A Note on the Selective Toxicity of Vincristine Sulfate on Chick-Embryo Sensory Ganglia in Tissue Culture Get access José A. Burdman José A. Burdman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 37, Issue 3, September 1966, Pages 331–332, https://doi.org/10.1093/jnci/37.3.331 Published: 01 September 1966 Article history Received: 11 January 1966 Published: 01 September 1966
Dissemination of Rous Sarcoma Virus as a Cause of “Metastases”
Authors: J. Spencer Munroe, Chester M. Southam
Journal: JNCI Journal of the National Cancer Institute (1961)

Chicks were given an inoculation of a cell-free preparation of Rous sarcoma virus into the wing web. After periods from 8 hours to 11 days, the inoculated wings were amputated under local anesthesia. Controls received the same virus inoculation but either were not amputated or had the uninoculated wing amputated. In the wing webs, sarcoma cells were first identified on day 4. On day 3 scattered cells of uncertain identity were sometimes found, but at 48 hours and earlier there was no evidence of tumor. Virus was not detectable by infectivity tests or by fluorescein-labeled antibody technique until day 4. The birds were killed at 15 or 25 days after inoculation so that the lungs could be studied for presence of tumors and virus, or were observed for 90 days to determine survival. Amputation of the virus-inoculated wing prior to day 5 delayed and decreased mortality and reduced the frequency with which sarcomas and Rous virus were found in lungs. However, even when amputation was performed 8, 16, 24, or 48 hours after inoculation, tumors and virus sometimes appeared in the lungs and some birds died of pulmonary sarcomas. Since amputation preceded appearance of sarcoma cells, these lung tumors must have resulted from early dissemination of virus from the inoculated wing.
Reduced-Intensity Transplantation for Lymphomas Using Haploidentical Related Donors Versus HLA-Matched Sibling Donors: A Center for International Blood and Marrow Transplant Research Analysis
Authors: Nilanjan Ghosh, Reem Karmali, Vanderson Rocha, Kwang Woo Ahn, Alyssa DiGilio, Parameswaran N. Hari, Veronika Bachanova, Ulrike Bacher, Parastoo Dahi, Marcos de Lima, Anita D’Souza, Timothy S. Fenske, Siddhartha Ganguly, Mohamed A. Kharfan-Dabaja, Tim D. Prestidge, Bipin N. Savani, Sonali M. Smith, Anna M. Sureda, Edmund K. Waller, Samantha Jaglowski, Alex F. Herrera, Philippe Armand, Rachel B. Salit, Nina D. Wagner-Johnston, Ephraim Fuchs, Javier Bolaños-Meade, Mehdi Hamadani
Journal: Journal of Clinical Oncology (2016)

Related donor haploidentical hematopoietic cell transplantation (Haplo-HCT) using post-transplantation cyclophosphamide (PT-Cy) is increasingly used in patients lacking HLA-matched sibling donors (MSD). We compared outcomes after Haplo-HCT using PT-Cy with MSD-HCT in patients with lymphoma, using the Center for International Blood and Marrow Transplant Research registry.We evaluated 987 adult patients undergoing either Haplo-HCT (n = 180) or MSD-HCT (n = 807) following reduced-intensity conditioning regimens. The haploidentical group received graft-versus-host disease (GVHD) prophylaxis with PT-Cy with or without a calcineurin inhibitor and mycophenolate. The MSD group received calcineurin inhibitor-based GVHD prophylaxis.Median follow-up of survivors was 3 years. The 28-day neutrophil recovery was similar in the two groups (95% v 97%; P = .31). The 28-day platelet recovery was delayed in the haploidentical group compared with the MSD group (63% v 91%; P = .001). Cumulative incidence of grade II to IV acute GVHD at day 100 was similar between the two groups (27% v 25%; P = .84). Cumulative incidence of chronic GVHD at 1 year was significantly lower after Haplo-HCT (12% v 45%; P < .001), and this benefit was confirmed on multivariate analysis (relative risk, 0.21; 95% CI, 0.14 to 0.31; P < .001). For Haplo-HCT v MSD-HCT, 3-year rates of nonrelapse mortality (15% v 13%; P = .41), relapse/progression (37% v 40%; P = .51), progression-free survival (48% v 48%; P = .96), and overall survival (61% v 62%; P = .82) were similar. Multivariate analysis showed no significant difference between Haplo-HCT and MSD-HCT in terms of nonrelapse mortality (P = .06), progression/relapse (P = .10), progression-free survival (P = .83), and overall survival (P = .34).Haplo-HCT with PT-Cy provides survival outcomes comparable to MSD-HCT, with a significantly lower risk of chronic GVHD.
Development of a cost-efficient psychogeriatrics service
Authors: J J Barsa, F Kass, C C Beels, B Gurland, E Charles
Journal: American Journal of Psychiatry (1985)

Various cost-efficient and space-efficient methods were used to expand outpatient services to the elderly at a teaching hospital's psychiatry clinic over a 2-year period. During this time the active treatment census of elderly patients more than doubled, to 185 patients. Only one enrolled patient required psychiatric hospitalization, and none required nursing home placement in the 2 years. Except for the geriatrics service director, no new paid staff and no extra space were required to form the service. The authors review the methods that seemed most beneficial to the service.
AB0871 Rehabilitation Program Improves Functional Status and Quality of life in Patients with Knee Osteoarthritis
Authors: R.I. Marcu, R. Traistaru, S. Patru, A.C. Bighea, R.S. Popescu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Knee osteoarthritis is a long- term disease and its medical management is not always effective in reducing pain or improving mobility. The studies concerning the quality of life in patients with knee osteoarthritis proved the impact of functional impairment on their daily living activities and on their social and professional life. <h3>Objectives</h3> The main purpose of this observational study was to evaluate the efficacy of complex rehabilitation treatment and its influence on the functional status and on the quality of life in patients with knee osteoarthritis and to identify possible correlations between various clinical and functional parameters. <h3>Methods</h3> The study included 138 patients with knee osteoarthritis (diagnosed according to the American College of Rheumatology criteria), mean age 64.52±11.63 years. All patients performed a complex rehabilitation program for 12 days and were evaluated clinical and functional at baseline, at 2 weeks and at 8 weeks. We used VAS scale for pain measure, WOMAC index for functional status and the Short Form 36 Helth Survey (SF-36) for assessing quality of life. The physical performance measures included the Six- Minute Walk Test (SMW) and the Timed "Up &amp; Go" Test (TUG). <h3>Results</h3> The efficacy of physical-kinetic treatment is reflected by statistically significant improvements (p&lt;0.05) of mean scores for functional status and for quality of life questionnaires, for pain evaluated on a visual analogue scale (VAS). WOMAC influence on SF-36 improvement is well above 50%; there is a correlation between indicators estimated as moderately high (0.8). Multivariate analysis showed that physical performance measures (SMW and TUG) correlated statistically with pain measure (VAS score) and WOMAC index. <h3>Conclusions</h3> Improvement of the clinical and functional parameters has a significant impact on increasing the quality of life in patients with knee osteoarthritis. <h3>Disclosure of Interest</h3> None declared
Inhibition and Enhancement Effects of Hypochlorite on Ascites Tumor Cell Metabolism and Growth, and on Host Resistance
Authors: John Laszlo, Dean Burk, Kent Wight
Journal: JNCI Journal of the National Cancer Institute (1959)

Hypochlorite (500 ppm) inhibited the respiration and glycolysis of Krebs-2 carcinoma mouse ascites cells over 90 percent and rendered the cells totally nonviable in inoculation tests. Hypochlorite gave much less inhibition of the metabolism of Krebs-2 carcinoma slices, and even increased the oxygen consumption of normal liver slices. A single optimal, intraperitoneal injection of inorganic sodium hypochlorite solution (Clorox) or of “organic” hypochlorite (Clorpactin XCB) gave greater than a 100 percent increase in the median survival time of mice that had been inoculated previously with Krebs-2 ascites cells. The effect was optimal when approximately 2 mg. of hypochlorite in 0.5 cc. of water was administered 15 minutes post inoculation, and diminished to about a 25 percent increase in median survival time when given 24 hours post inoculation. Supraoptimal doses of hypochlorite enhanced the rate and dissemination of tumor growth, as did repeated daily administration. Host pretreatment with hypochlorite, given intraperitoneally or subcutaneously, similarly enhanced the growth and virulence of the tumor cells. The enhancement of tumor growth was not specific for hypochlorite but was also observed upon pretreatment by either formalin, methotrexate, total-body irradiation, or host temperature stress for 24 hours at 37° C. Hydrocortisone or prednisolone pretreatments did not enhance but retarded tumor growth. Moreover, the effects observed with Krebs-2 ascites were also noted with lymphoid leukemia neoplasm P388 that had arisen in DBA mice and had been carried in ascites form in (BALB/c×DBA/2)F1 hybrids. The mechanism of tumor growth enhancement produced by a variety of chemical and physiological agents thus appears to involve more than mere loss of immune response.
SAT0247 Combined Hip Abduction Angle Measured by Using Iphone Compass Application; A Novel Measurement Tool to Assess Hip Mobility: Table 1.
Authors: H. Yarkan, B. Zengin, G. Kenar, P. Cetin, I. Sari, F. Onen, N. Akkoc
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Intermalleolar distance (IMD) is a component of the Bath ankylosing spondylitis metrology index (BASMI) and measures abduction of the hips. New generations of smartphones are equipped with a gyroscope and an accelerometer which in combination with a smartphone9s operating system or specific software applications can be used for various inclinometric functions. <h3>Objectives</h3> The purpose of this study was to estimate the intra and inter-rater reliability of using iphone built in compass application, as compared to IMD in the assessment of hip abduction in patients with Ankylosing Spondylitis (AS). <h3>Methods</h3> The study sample included 20 AS patients (6 females, 14 males) with a mean age of 47.8 (±10.2). BASMI scores were obtained from patient charts. Two examiners measured intermalleolar distance as the standard method at two different time points with the patient lying in a supine position. Then combined abduction of the hips angle (CAHA) was measured by iPhone compass application twice. To stabilize the iphone9s position during measurements an iphone case and an elastic bandage with velcro patches were used. Intra-rater and inter-rater reliability were examined with intra-class correlation coefficients (ICC). The validity was assessed by Pearson Correlation analysis. <h3>Results</h3> The mean BASMI score was 43 (±22.7). The mean scores for BASDAI, ASDAS and BASFI were 3.7 (±19.9), 2.9 (±0.96) and the 3.5 (±24.02), respectively. The mean IMD was 83.6 cm (±24.4) for rater 1 and 83.4cm (SD: 23.1) for rater 2. The mean CAHA was 51.2° (±18.3) for rater 1 and 55.6°(±20.5) for rater 2. We observed almost an excellent intra and inter-rater reliability for both methods (Table 1). CAHA measurements showed a strong correlation with IMD (r=0.74). <h3>Conclusions</h3> The results of this study suggest that measurement of combined hip abduction angle using iphone, which is not to be affected by patients9 height, can be used as a novel hip mobility measure. <h3>Disclosure of Interest</h3> None declared
PTH-155 Significance of microscopically incomplete resection margin following oesophagectomy for oesophageal cancer
Authors: SR Markar, C Mariette
Journal: Gut (2015)

<h3>Introduction</h3> The aim of this study was to establish if R1 resection margin after oesophagectomy was (i) a poor prognostic factor independent of patient and tumour characteristics, (ii) a marker of tumour aggressiveness and (iii) to look at the impact of adjuvant treatment in this subpopulation. <h3>Method</h3> Data was collected from 30 European centres from 2000–2010. Patients with an R1 resection margin (n = 242) were compared to those with an R0 margin (n = 2573) in terms of short- and long-term outcomes. Propensity score matching and multivariable analyses were used to compensate for differences in baseline characteristics. <h3>Results</h3> Important factors significantly associated with an R1 resection margin included an upper third oesophageal tumour location, preoperative malnutrition and pathological stage III. There were significant differences between the groups in postoperative histology, with an increase in pathological stage III and TRG 4/5 in the R1 group. Total average lymph node harvests were similar between the groups, however there was an increase in the number of positive lymph nodes seen in the R1 group. Propensity matched analysis confirmed R1 resection margin was significantly associated with reduced overall survival and increased overall, loco-regional, and mixed tumour recurrence. Similar findings were seen in the subgroup that received neoadjuvant chemoradiation. In R1 patients adjuvant therapy improved survival and reduced distant recurrence however failed to affect locoregional recurrence. <h3>Conclusion</h3> This large multi-centre European study provides evidence to support the notion that R1 resection margin is a prognostic indication of aggressive tumour biology with a poor long-term prognosis. <h3>Disclosure of interest</h3> None Declared.
TCT-190 Biolimus Eluting StenT For de novo coRonary artery dIsease in patiENts with Diabetes mellituS: the BESTFRIENDS multicentre registry.
Authors: Emanuele Meliga, Giacomo G. Boccuzzi, Maria Rosa Conte, Mauro De Benedictis, Andrea Gagnor, Azeem Latib, Primiano Lombardi, Alessandro Lupi, Innocenzo Scrocca, Alessandro Sticchi, Ferdinando Varbella
Journal: Journal of the American College of Cardiology (2013)
PTU-273 Postoperative symptomatic pelvic collections are more common after redo than after initial proctectomy for rectal cancer following neoadjuvant therapy
Authors: I Montroni, N Haim, M Franceschin, S Moon, D Bekele, R Akiba, G Dasilva, SD Wexner
Journal: Gut (2015)

<h3>Introduction</h3> Proctectomy can be complicated by pelvic collection adversely affecting recovery; pelvic drains may reduce the incidence and/or severity of pelvic collections. Redo pelvic surgery is more complex due to chronic pelvic infection after anastomotic leak or cancer recurrence. The incidence of pelvic collection following redo proctectomy after neoadjuvant chemoradiation therapy (CRT) is unknown. This study evaluated the incidence of symptomatic pelvic collections in patients undergoing redo proctectomy compared to primary surgery after CRT. <h3>Method</h3> After IRB approval, data from patients with rectal cancer undergoing open redo proctectomy following neoadjuvant CRT between 2006–2013 were reviewed. The “redo” (Group A) was matched based on clinical characteristics and surgical strategies [Abdominoperineal resection (APR) vs low anterior resection with diverting loop ileostomy (LAR)] with patients undergoing primary proctectomy (Group B). All patients had pelvic drain at the time of surgery. Incidence of postoperative symptomatic pelvic collections was compared between groups. Clinical relevance of pelvic collection was evaluated by presence of leukocytosis, tachycardia, fever and positive fluid culture at diagnosis. <h3>Results</h3> 42 patients in Group A were matched with 42 patients in Group B based on age (58 ± 11 vs 60.9 ± 10 years), Body Mass Index (25.4 ± 5 vs 26.9 ± 4.7 kg/m<sup>2</sup>) ASA score, Charlson Comorbidity Index (2.8 ± 1.2 vs 2.7 ± 1) and surgical strategy (21 APR/21 LAR Group A vs 18 APR/24 LAR Group B). Postoperative symptomatic collections occurred in 10/42 (24%) patients in Group A vs 4/42 (9%) in Group B (p &lt; 0.05). Collections were treated with percutaneous drain placement. Collections were associated with anastomotic leak in 3/5 vs 2/3 cases (p = ns). Mean interval between surgery and surgical drain removal was 15 ± 12 vs 5 ± 2 days while time from surgery to pelvic collection diagnosis was 15 ± 5 vs 13 ± 8 days in Group A and B, respectively. In Group A, 6/10 patients had a collection diagnosed after surgical drain removal while 4/10 patients developed pelvic collection despite presence of a surgical drain. All patients (4/4) in Group B had drain removal at the time of diagnosis. Tachycardia was the most common symptom indicating pelvic collection formation (p &lt; 0.05). Bacterial growth was noted in 8/10 vs 2/4 cases. <h3>Conclusion</h3> Redo pelvic surgery following neoadjuvant CRT is associated with a significantly higher risk of pelvic collection development compared to <i>de novo</i>index proctectomy, despite drain placement during surgery. Up to 40% of patients required a second percutaneous drain while the initial surgical drain was in place. <h3>Disclosure of interest</h3> None Declared.
A discriminant validity study of negative symptoms with a special focus on depression and antipsychotic medication
Authors: R R Lewine
Journal: American Journal of Psychiatry (1990)

If the construct validity of the negative symptom syndrome is to be established, the conceptual and operational overlap between negative symptoms and other syndromes such as depression and the effects of medication must be explained. The author assessed 26 patients with schizophrenia and 21 patients without schizophrenia, most of whom had depression, at the end of an average 2-week drug washout period and after approximately 2 months of psychotropic medication administration. Negative symptoms were remarkably consistent in patients with schizophrenia despite pharmacological intervention. In contrast, the patients without schizophrenia manifested significant decreases in negative symptoms.
Abnormal dexamethasone suppression test results in depressed and nondepressed children
Authors: R Livingston, C J Reis, I C Ringdahl
Journal: American Journal of Psychiatry (1984)

In a series of 15 children, abnormal dexamethasone suppression test (DST) responses were most common in depressed children and those with separation anxiety disorder. The authors raise questions about the specificity of the DST and the nature of separation anxiety.
Lack Of Benefit From Surveillance PET-CT In Transformed Indolent Lymphoma (TrIL) In Complete Metabolic Remission (CMR) Following Therapy
Authors: Chan Y Cheah, Michael J. Dickinson, Anupkumar George, Michael S Hofman, Kate Burbury, David Ritchie, H Miles Prince, Kirsten Herbert, Max Wolf, Elchanan H. Januszewicz, Dennis A Carney, Simon J. Harrison, Constantine S Tam, John F. Seymour
Journal: Blood (2013)
THE PHYSIOLOGY OF THE THYROID GLAND.
Authors: L J DE GROOT
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 43-1974
Authors: Richard C. Cabot, Robert E. Scully, Betty U. McNeely, C. Miller Fisher, Edward P. Richardson, Thomas McC. Chesney
Journal: New England Journal of Medicine (1974)

Presentation of Case First admission. A 45-year-old woman entered the hospital because of difficulty with speech and memory.For the past year she had been increasingly nervous and forgetful. She confused the names of her children, stuttered and had trouble grasping current events. Eight months before admission she left her job as a teletype operator because of increasing difficulty with her work and a concern that co-workers were talking about her. She complained of daily transient tingling sensations in the right upper limb, sometimes affecting individual fingers and at other times the entire arm. On two occasions there was . . .
Naturally Occurring Human Antibody to Neuraminidase-Treated Human Lymphocytes
Authors: Bruce N. Gray
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Naturally Occurring Human Antibody to Neuraminidase-Treated Human Lymphocytes Get access Bruce N. Gray Bruce N. Gray Associate in Research Lahey Clinic Foundation, 605 Commonwealth Avenue Boston, Massachusetts 02215. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 2, February 1976, Page 211, https://doi.org/10.1093/jnci/56.2.211 Published: 01 February 1976