tbuckley/cabot-search huggingface dataset:
Demonstration of Non–Small-Cell Lung Carcinoma by Indium-111 Octreotide Scintigraphy
Authors: BA D. NGUYEN, MICHAEL C. ROARKE
Journal: Clinical Nuclear Medicine (2000)

Octreotide is a somatostatin analog applied in the scintigraphic imaging of neuroendocrine tumors and tumors exhibiting somatostatin receptors such as meningioma, breast, medullary thyroid, and small-cell lung carcinomas. Although non–small-cell lung carcinoma (NSCLC) does not have receptor characteristics of the two neoplastic categories just noted, its demonstration by octreotide has been reported. Reported here is a case of lung adenocarcinoma detected by somatostatin receptor scintigraphy. The mechanism of octreotide uptake by NSCLC is briefly reviewed and discussed.
Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation
Authors: LD Cripe, VM Gelfanov, EA Smith, DR Spigel, CA Phillips, TG Gabig, S-H Jung, J Fyffe, AD Hartman, P Kneebone, D Mercola, GS Burgess, H Scott Boswell
Journal: Leukemia (2002)
Titration of Serum <i>p53</i> Antibodies Predicts Pathological Response in Women with Operable Early Stage Breast Cancer Receiving Preoperative Sequential FEC and Docetaxel Chemotherapy.
Authors: S. Hideo, N. Yoshiaki, K. Hideotoshi, T. Kimihiro, S. Satoko, K. Chinami, M. Emiko, N. Sumiko, N. Kenichi, O. Shinji
Journal: Cancer Research (2009)

Abstract Background: In breast cancer, emerging dates demonstrate that p53 mutation is associated with response to preoperative chemotherapy, indicating that p53 mutation may be a predictive factor for response to preoperative chemotherapy. The accumulation of mutant p53 protein has been found to induce the formation of serum p53 IgG antibodies in breast cancer patients. A highly specific quantitative enzyme-linked immunosorbent assay (ELISA) kit has been developed to detect p53 antibody titers. However, whether this titration of serum p53 antibody reflects response to preoperative chemotherapy is unknown. The aim of this study was to evaluate the clinical implication of serum p53 antibody titers as a predictive factor for preoperative chemotherapy in breast cancer.Patinets and Methods: In this study, we analyzed 103 women with operable early stage breast cancer treated by preoperative chemotherapy and definitive curative surgery. Patients received four cycles of FEC (fluorouracil 500 mg/m2, epirubicin 100 mg/m2, cyclophosphamide 500 mg/m2 q3w) followed by four cycles of docetaxel (75 mg/m2 q3w). The pretreatment serum samples were used to determine the p53 antibody titers. The test's cut-off value was determined to be 1.3 U/ml based on reference distribution in healthy control individuals.Results: Twenty-three of 103 patients (22.3%) were positive for serum p53 antibody. The frequency of pathological complete response (pCR) was significantly higher in cases with positive for p53 antibody than in patients with negative for p53 antibody (9/23 or 39% vs. 15/80 or 23%; p=0.04). According to intrinsic subtypes, the tendency was most emphasized in cases with HER2-positive cases (6/9 or 67% vs. 8/25 or 32%). Interestingly, among 8 patients with high p53 antibody titers (&amp;gt;100 IU/ml) 7 patients experienced pCR and remaining one patients showed only foci invading areas in primary tumor and complete remission in axillary lymph node metastasis, suggesting that the value of p53 antibody titers may more precisely predict response to preoperative chemotherapy.Conclusion: p53 mutation analysis using titration of serum p53 antibody is useful predictive test for response to preoperative chemotherapy in patients with breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2038.
A2.15 SRC-family kinases independent integrin signalling is required for elevated extracellular vesicle production of neutrophils
Authors: AM Lőrincz, D Szombath, F Kolonics, Wisniewski É, A Mócsai, E Ligeti
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Beta-2 integrin (CD18) and the Src-family kinases (Hck, Fgr, Lyn) are required for development of autoimmune arthritis <i>in vivo</i>. Immune cell or platelet derived extracellular vesicles (EV) were shown to play a crucial role in synovial inflammation and local joint destruction by activating multiple signalling pathways in synovial fibroblasts including NF-κB, activator protein-1, p38 mitogen-activated protein kinases and c-Jun N-terminal kinase pathways. Upon activation, synovial fibroblasts upregulated cyclooxygenase 2 and prostaglandin E synthase, induced the release of matrix metalloproteases, and increased the production of proangiogenic chemokines. In this present study we aimed to reveal the role of integrin signalling and Src-family kinases in neutrophilic granulocyte EV production. <h3>Methods</h3> CD18, CD11a, CD11b, Src-family knockout and wild-type neutrophils were separated from murine bone marrow and then stimulated with opsonized yeast. Extracellular vesicles were separated by two step centrifugation and filtration. The separated vesicles were counted and analysed with EV optimised flow cytometry. The structure of EVs was analysed with electron microscopy. Phagocytosis of opsonized bacteria by knockout neutrophils was also determined. <h3>Results</h3> Strong phagocytosis of bacteria was seen in case of wild-type cells. CD18, CD11b or Src-family kinases deficient cells showed a strongly impaired phagocytosis however it remained intact if CD11a integrin was knocked out. All knockout and the wild-type cells produced right side out annexin V positive EVs spontaneously. After opsonized yeast activation EV production by wild-type cells increased two-fold. This elevated EV production was completely or partially inhibited in the absence of CD18 or CD11b resp. The elevated EV production was not affected if CD11a was missing and surprisingly also if all the Src-family members were knocked down. <h3>Conclusion</h3> Murine bone marrow derived neutrophils are able to increase EV production after a complex biological activation. This activation signal needs functioning Mac-1 complex but not the Src-family kinases and the massive cytoskeletal reorganisation induced by the phagocytosis.
P1180 CAN A LIFESTYLE MODIFICATION INTERVENTION IMPROVE RISK FACTORS FOR A NEGATIVE RESPONSE TO PEGINTERFERON TREATMENT IN PATIENTS WITH CHRONIC HEPATITIS C, CIRRHOSIS AND OBESITY?
Authors: A. Agarwal, V. Pattullo, M. Garcia-Saenz-de-Sicilia, S. Sockalingam, I.G. Fantus, J.P. Allard, E.J. Heathcote, J.J. Feld, A. Duarte-Rojo
Journal: Journal of Hepatology (2014)
Reply
Authors: Tung‐Hung Su, Chi‐Ling Chen, Jia‐Horng Kao
Journal: Hepatology (2016)

We appreciate the comments of Antonio et al. about our recently published paper.1 Regarding the relatively lower incidence rate (48.4/10,000 person-years) of lymphoid neoplasm from patients with hepatitis C virus (HCV) in our cohort from Taiwan, the authors provide constructive opinions on other high-risk groups of patients for lymphoma development, including patients with cirrhosis and mixed cryoglobulinemia, patients with pathogenic Helicobacter strains, and individuals carrying the hemochromatosis gene mutations or hemoglobinopathies with elevated total body iron deposits. These high-risk groups of patients should receive closer monitoring for the possible development of lymphoid neoplasms. In a recent population-based cross-sectional study using the Taiwan Cancer Registry,2 the incidence rate of lymphoid neoplasms in Taiwan was found to be significantly lower than that in the United States according to the Surveillance, Epidemiology, and End Results (SEER) database (standardized incidence rate ratio [SRR], 0.46; 95% confidence interval [CI], 0.45-0.48). The overall incidence was also lower for non-Hodgkin lymphoma (SRR, 0.56; 95% CI, 0.54-0.57), particularly B cell non-Hodgkin lymphoma (SRR, 0.52; 95% CI, 0.51-0.54). These results suggest that common ethnic differences in genetic background might play an important role in B cell transformation into lymphoid neoplasms.2 The risk factors for lymphoma development are heterogeneous. We concur with the comments from Antonio et al. that at-risk groups must be identified and that these patients need to be followed up closely for lymphoid neoplasms. Among the known risk factors, HCV is a well-documented one. In the era of direct antiviral agents against HCV infection,3 whether population-based eradication of HCV will lead to a significantly lower incidence of lymphoid neoplasms awaits further examination. Tung-Hung Su, M.D., Ph.D.1,2,3 Chi-Ling Chen, Ph.D.3 Jia-Horng Kao, M.D., Ph.D., F.A.A.S.L.D.1,2,3,4 1Division of Gastroenterology and Hepatology Department of Internal Medicine National Taiwan University Hospital Taipei, Taiwan 2Hepatitis Research Center National Taiwan University Hospital Taipei, Taiwan 3Graduate Institute of Clinical Medicine National Taiwan University College of Medicine Taipei, Taiwan 4Department of Medical Research National Taiwan University Hospital Taipei, Taiwan
S92 Risk Factors and Outcome For Emergency Presentation in Lung Cancer Patients: Abstract S92 Table 1
Authors: P Beckett, R Stanley, I Woolhouse, R Hubbard, L Tata
Journal: Thorax (2012)

<h3>Introduction</h3> The National Cancer Intelligence Network recently published an analysis of 226,000 cases of cancer and showed that 23% of all cancers had an emergency presentation as their “route to diagnosis”. This figure was higher for lung cancer at 38% with an indication that survival is particularly poor for these patients, but the analysis lacked detailed information on other key clinical characteristics. We have used data from the National Lung Cancer Audit to investigate the characteristics of, and outcomes for, patients with emergency presentation. <h3>Methods</h3> We obtained data on 100,884 cases of histologically-confirmed or presumed NSCLC and used multivariate logistic regression to quantify the association of emergency presentation, allowing for age at diagnosis, sex, stage, performance status, co-morbidity and socioeconomic status. Survival was calculated using the Kaplan-Meier method and Cox proportional hazards model. <h3>Results</h3> 51% were referred by their GP, 21% by another secondary care consultant, 14% following an emergency admission to hospital, 7% following an emergency presentation to A&amp;E and the remaining 7% by other routes. A binary variable was created by combining those referred following emergency admission or emergency presentation to A&amp;E (‘Acute’) and by combining all other cases (‘Non-Acute’). Table 1 shows the multivariate odds ratios for acute presentation, demonstrating that higher disease stage and worse performance status are characteristics most associated with an acute presentation. At 1 year, there were 17,165 deaths in the acute group, leaving 16.3% still alive (median survival 77 days), compared to 49,177 deaths in the non-acute group, leaving 38.8% still alive (median survival 259 days). The unadjusted hazard ratio for death at 1 year in those with an emergency presentation was 2.2 (95% CI 2.16–2.24, p&lt;0.001), and after adjustment for age, sex, stage, performance status, co-morbidity and socioeconomic status, the corresponding value was 1.56 (95% CI 1.53–1.60, p&lt;0.001). <h3>Conclusions</h3> Emergency presentations are associated with poorer outcomes, but they also consume large amounts of healthcare spending which could be better utilised in a rapid and efficient referral and diagnostic pathway. Efforts to better understand the gaps in current service provision that allow so many patients to present so late are long overdue.
Medical versus Surgical Therapy for Acute Coronary Insufficiency
Authors: Richard Selden, William A. Neill, Leonard W. Ritzmann, J. Edward Okies, Richard P. Anderson
Journal: New England Journal of Medicine (1975)

Forty patients with acute coronary insufficiency, including continued angina at rest and reversible ischemic electrocardiographic changes after hospitalization ("high-risk" subgroup), were randomly allotted to medical therapy or urgent surgical coronary bypass groups. In four months there were no deaths and two myocardial infarctions in 19 medical patients and one death and three myocardial infarctions in 21 surgical patients. Left ventricular ejection fraction did not change significantly in either group. The surgical patients had significantly higher functional capacities at four months as judged by lower symptomatic functional class (P <0.01), higher exercise angina threshold (P <0.001), higher pacing angina threshold (P <0.0001), and higher myocardial lactate extraction during pacing (P <0.0001). Initial medical management of patients with acute coronary insufficiency followed by elective coronary bypass in patients with continued disabling angina pectoris is a reasonable alternative to emergency bypass. (N Engl J Med 293:1329–1333, 1975)
CORONARY AORTA SYSTOLIC PRESSURE INDEX: A NOVEL INDEX OF EVALUATING CORONARY ARTERY STENOSES BASED ON PEAK SYSTOLIC PRESSURE GRADIENTS
Authors: Khawaja Afzal Ammar, Fatima A Husain, Syed Shahab Kazmi, Arsalan Riaz, Mirza Nubair Ahmad, Haroon Yousaf, Imran Husain, Anjan Gupta
Journal: Journal of the American College of Cardiology (2015)
Program Exposes Minority Students to Science Careers
Authors: C. K. Wittenberg, J. Battaglia
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Program Exposes Minority Students to Science Careers Get access Clarissa K. Wittenberg, Clarissa K. Wittenberg Battaglia is a Los Angeles-based freelance writer Search for other works by this author on: Oxford Academic PubMed Google Scholar Joe Battaglia Joe Battaglia Battaglia is a Los Angeles-based freelance writer Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 13, 1 July 1992, Page 1004, https://doi.org/10.1093/jnci/84.13.1004 Published: 01 July 1992
AB1172-HPR The Relationship between Psychological Conditions and Neck Pain Paremeters on Patients with Mechanical Chronic Neck Pain
Authors: H.E. Kilinç, D.I. Ince
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Chronic mechanical neck pain is one of the most common musculoskeletal problems. It is known that close relationship between pyschologic conditions of patients and chronic musculokeletal problems (1). <h3>Objectives</h3> The aim of study was to determine pyschologic profile of patients with chronic mechanical neck pain and relationship between pyschologic conditions of patients and neck pain parameteres. <h3>Methods</h3> 44 Chronic mechanical neck pain patients with 16,95±5,89 (mean ± standart deviation) Neck Disablity Index Points ages between 35,04±10,77 (36 women, 8 men) were included to study. Firstly, demographic informations of patients were recorded. State-Trait Anxiety Inventory was applied to all patients. Pain sensitivity of Upper trapezius and cervical paravertebral muscles were assesed by using Algometer device (Algometer Commender Jtech Medical 801-478). Visual Analog Scale was used for determinig neck pain level. <h3>Results</h3> It was determined that %25 of all patients (11 patients) using antidepressant drugs at least 3 months. Stait Anxiety Inventory score of patients were 45,60±9,55 points (moderate anxiety). Stait Anxiety Inventory score and Neck Disability Index scores were positive correlated (r: 0,325; p:0,031). It is also fund Stait Anxiety Inventory score and Upper Trapezius muscle pain sensitivity were positive correlated (r: 0,317; p:0,036). <h3>Conclusions</h3> Pyschologic status in patients with mechanical neck pain, affects the level of disability. Therefore, mechanical neck pain treatment, should include a more holistic approach including psychological support. <h3>References</h3> Lin, R.F., Chang, J.J., Lu, Y.M., Huang, M.H.,Lue, Y.J. (2010) Correlations between quality of life and psychological factors in patients with chronic neck pain. Kaohsiung J Med Sci, 26 (1), 13-20. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2694
Abstract 2507: Triple agent therapy combining radiation with AMG479 (IGF1R antibody) and panitumumab (EGFR antibody) in a head and neck tumor model
Authors: Fumihiko Matsumoto, Uma Raju, David Valdecanas, Luka Milas, K Kian Ang
Journal: Cancer Research (2011)

Abstract PURPOSE: The combination of radiation with concurrent chemotherapy improves local-regional control and overall survival in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). However, its acute and chronic toxicity have raised concerns and thereby prompted the search for more biologically sound therapeutic strategy, e.g., targeting receptor tyrosine kinases (RTKs) that are differentially expressed between tumors and normal tissues. The current study tested the therapeutic benefits of co-targeting two RTKs, namely, epidermal growth factor receptor (EGFR) by panitumumab (Pmab) and insulin-like growth factor receptor-1 (IGF-1R) by AMG479 to enhance tumor response to radiation. METHODS AND MATERIALS: A HNSCC model, FaDu, was used for assessing the effects of AMG479, and Pmab to improve tumor response to radiation by in vitro clonogenic cell survival assay and in vivo tumor growth delay assay. Various doses and administration scheduling of these agents relevant to radiation were tested. RESULTS: In vitro study showed that Pmab significantly enhanced the radiosensitivity of FaDu with an enhancement factor (EF) of 1.4 at 0.5 survival fraction. AMG479 given alone or concurrently with Pmab had no affects in normal (10% serum) culture media. In vivo xenograft studies showed that Pmab or AMG479 given as single agent enhanced the tumor response to fractionated radiation (2 Gy twice a day for 6 d) in a dose and schedule dependent manner. The maximum EF was 1.1 for AMG479 and 1.7 for Pmab. The effects of combining Pmab and AMG479 with radiation depended markedly on the scheduling. The best effects were achieved when (1) Pmab and AMG479 were given concurrently daily starting 4 d before radiation for a total of 15 days resulting in an EF of 3.0 or (2) Pmab and AMG479 were given sequentially commencing Pmab 4 d before radiation for 15 d and AMG479 after completion of radiation also for 15 d yielding an EF of 2.9. However, administering AMG479 before radiation followed by Pmab was much less effective (EF: 2.0). CONCLUSIONS: Our results showed Pmab enhanced FaDu response to radiation. AMG479 markedly increased tumor response when given together or following Pmab, in conjunction with radiation. These findings provide the rationale for clinical testing of the combination of Pmab and AMG479 for the treatment of HNSCC along with the most promising regimen of administration. Supported by Amgen Inc., Thousand Oaks, CA Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2507. doi:10.1158/1538-7445.AM2011-2507
Artifactual Perfusion Defect from a Hypertrophic First Costosternal Articulation
Authors: DAVID M. SCHUSTER, KENNETH SCHEIDT
Journal: Clinical Nuclear Medicine (1997)

A 66-year-old man had shortness of breath and a clear chest x-ray. Tc-99m MAA perfusion study revealed a moderate-sized, wedge-shaped defect in the left upper lobe seen on oblique images. Neither the posterior perfusion view, nor the posterior xenon-133 ventilation scan demonstrated the abnormality. However, correlation to a previous chest CT established that this defect was due to a hypertrophic left first costosternal articulation. A confident reading of "normal" was rendered. Awareness of such artifactual causes of perfusion defects is important in the interpretation of radionuclide lung scans.
Estrogen Receptor Expression: Possible Predictor of Pathological Complete Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer Patients.
Authors: J. Wu, K. Shen, X. Chen, C. Chen, Z. Hu, G. Liu, G. Di, J. Lu, J. Wu, Z. Shao, Z. Shen
Journal: Cancer Research (2009)

Abstract BackgroundEstrogen receptor(ER) status has been found to correlate inversely to pathologic complete response (pCR) rates of neoadjuvant chemotherapy(NAC) of breast cancer. However, not all ER-positive breast cancer respond equally to NAC. The present study aimed to determine the relationship between different ER expression level with pCR in locally advanced breast cancer(LABC) patients who have received NAC.MethodsA retrospective study of 332 female unilateral LABC patients undergoing NAC was performed. All patients were confirmed as invasive breast cancer before treated with NAC, including VE (vinorelbine, epirubicin), CEF (cyclophosphamide, epirubicin, fluorouracil) and PCb regimen (paclitaxel, carboplatin). All patients underwent radical surgery and pCR was defined as the absence of invasive breast cancer in both breast and axillary lymph nodes. ER status were checked using the established immunohistochemical(IHC) method and defined as negative, weakly positive(1+), medium positive(2+) and strongly positive(3+). Binary logistic regression was performed to determine the independent predictors of pCR.ResultsER negativity, 1+, 2+ and 3+ were found in 156, 108, 37 and 31 patients, of which 42(26.9%), 21(19.4%), 3(8.1%) and 1 patients(3.2%) have achieved pCR. Binary logistic regression showed that different ER expression level(P=0.021) and HER2 status(P=0.007, hazard ratio[HR] =2.557, 95% confidence interval[CI]: 1.297∼5.038) were significantly associated with the pCR rates. pCR was much more likely to occur in patients with ER-negative(P=0.024, HR =13.119, 95% CI: 1.402∼122.774) or ER 1+(P=0.025, HR=12.928, 95% CI: 1.388∼120.390) tumors than those with ER 3+ tumors.ConclusionER weekly positive patients also gain considerable benefit from NAC, which is probably less effective in ER strongly positive patients in terms of pCR. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 1104.