tbuckley/cabot-search huggingface dataset:
Atopic dermatitis is not independently associated with nonfatal myocardial infarction or stroke among <scp>US</scp> women
Authors: A. M. Drucker, W.‐Q. Li, E. Cho, T. Li, Q. Sun, C. A. Camargo, A. A. Qureshi
Journal: Allergy (2016)

Abstract We aimed to determine the association between atopic dermatitis ( AD ) and cardiovascular events in the Nurses' Health Study 2, a cohort of US women. We used logistic regression models to calculate age‐ and multivariate‐adjusted odds ratios ( OR ) and 95% confidence intervals ( CI ) for the associations between history of AD and nonfatal MI and nonfatal stroke. Of the 78 702 participants in our analysis, 7916 (10%) had a history of AD . There were 392 and 391 cases of nonfatal MI and stroke, respectively. AD was not associated with MI in age‐ or multivariate‐adjusted analyses. AD was significantly associated with stroke in the age‐adjusted analysis ( OR 1.38, 95% CI 1.03–1.85). This was no longer significant in multivariate models that adjusted for hypertension, hypercholesterolemia and diabetes ( OR 1.31, 95% CI 0.98–1.76) and atopic comorbidities ( OR 1.17, 95% CI 0.86–1.58). AD was not independently associated with nonfatal MI or stroke in this study.
RO-07SINGLE INSTITUTION OUTCOMES FOLLOWING PROTON THERAPY FOR UNITED KINGDOM CHILDREN WITH CENTRAL NERVOUS SYSTEM TUMORS REFERRED OVERSEAS
Authors: Daniel J. Indelicato, Julie A. Bradley, Ronny L. Rotondo, Matthew D. Hall, Jenny E. Gains, Eric S. Sandler, Philipp R. Aldana, Christopher G. Morris, Nancy P. Mendenhall
Journal: Neuro-Oncology (2016)
Case 23-1965
Authors: Marian W. Ropes, Benjamin Castleman
Journal: New England Journal of Medicine (1965)

Presentation of CaseA seventy-eight-year-old man was admitted to the hospital because of hemoptysis.He had been well until thirteen years previously, when there was the onset of rheumatoid arthritis, which progressed to the extent that seven years later he was limited to a chair-and-bed existence. Salicylates, prednisone and adrenocorticotropic hormone (ACTH) were given but were of little benefit; all adrenocorticoid therapy was omitted one year before entry. During the six months before admission he was confined to bed. Five months before entry a cough productive of half a cup of yellow sputum daily developed, and penicillin was given in . . .
Obesity and robotic surgery: Associated ventilator indices and perioperative pulmonary complications.
Authors: Weiya Zhang Wysham, Kenneth H Kim, Jared Roberts, Stephanie Sullivan, Sukhkamal Bhullar, Dario Roque, Dominic T. Moore, Paola A. Gehrig, John Boggess, Warner King Huh
Journal: Journal of Clinical Oncology (2014)

5596 Background: Robotic surgery has been shown to be feasible in obese patients. However, there remains concern about the safety of robotic surgery in obese women who need gynecologic surgery, as the positioning required for pelvic surgery can exacerbate obesity-related changes in respiratory physiology. Our objective was to evaluate success and complication rates in obese women undergoing robotic gynecologic surgery and to assess variables that may be associated with complications. Methods: A retrospective chart review was performed on 1,035 obese patients who underwent robotic gynecologic surgery at two academic institutions between 2006 and 2012. Primary outcome was pulmonary complications. Secondary outcome was all-cause complications. Univariate logistic regression analysis was used to determine associations between patient baseline variables (age, BMI), operative variables (case length, trendelenburg time), ventilator parameters (tidal volume, peak inspiratory pressure) and complications (pulmonary, cardiac, other). Results: 146 patients (14%) had any complication. Only 33 patients (3%) had a pulmonary complication. Mean BMI was 39. Only increasing age was associated with a higher rate of pulmonary complications (p=0.03). None of the other patient variables including BMI, operative variables, or ventilator parameters were associated with pulmonary complications. Both age and longer case time were associated with a higher rate of all-cause complications (p<0.0005 and p=0.0028 respectively). Conclusions: The vast majority of obese patients can successfully tolerate robotic gynecologic surgery, and have overall low complications rates and even lower rates of pulmonary complications. Obesity was not predictive of robotic surgery tolerance or complications and can be safely undertaken in obese and even morbidly obese patients without significant complications.
MB-54HYPERFRACTIONATED RADIATION THERAPY (HFRT) WITHOUT UPFRONT CHEMOTHERAPY IN CHILDREN WITH AVERAGE-RISK MEDULLOBLASTOMA: MATURE FUNCTIONAL OUTCOMES AND LONG-TERM SURVIVAL
Authors: Tejpal Gupta, Savita Goswami, Jayita Deodhar, Aliasgar Moiyadi, Sridhar Epari, GodaJayant Sastri, Rakesh Jalali
Journal: Neuro-Oncology (2016)
MB-75EXPLOITING THE CELL CYCLE TO IMPROVE TREATMENT EFFICACY IN MEDULLOBLASTOMA
Authors: Raelene Endersby, Jacqueline Whitehouse, Hilary Hii, Mani Kuchibhotla, Brett Patterson, Brooke Strowger, Tobias Schoep, Nick Gottardo
Journal: Neuro-Oncology (2016)

MB-75. EXPLOITING THE CELL CYCLE TO IMPROVE TREATMENT EFFICACY IN MEDULLOBLASTOMA Raelene Endersby1, Jacqueline Whitehouse1, Hilary Hii1, Mani Kuchibhotla1, Brett Patterson1, Brooke Strowger1, Tobias Schoep1, and Nick Gottardo1,2; Telethon Kids Institute and University of Western Australia, Perth, WA, Australia; Princess Margaret Hospital, Subiaco, WA, Australia Medulloblastoma is themost common malignantbraincancerof childhood. It arises in the cerebellum and has a predilection to spread throughout the central nervous system. The most effective treatment is a combination of surgery, followed by radiotherapy and intensive cytotoxic chemotherapy; however, devastating long-term sequelae, due to the collateral damage of healthy tissue by these treatments, including developmental defects, psychosocial deficits and secondary tumours are frequently encountered by survivors, and for patients with metastatic disease prognosis are dismal. Using high-throughput, cell-based assays human medulloblastoma cells (n 1⁄4 6) were screened against a library of approximately 3200 compounds. Fifty effective compounds were identified and further in vitro assessment identified several drugs that enhanced the cytotoxic activity of clinically-used chemotherapeutics: cyclophosphamide, cisplatin, and gemcitabine. Cell cycle checkpoint kinase (CHK1/2) inhibitors (iCHKs), were further assessed in vivo using mice bearing intracranial implants of human medulloblastoma cells. When combined with DNA-damaging chemotherapeutics, iCHK treatment reduced tumour burden as measured by bioluminescence imaging and significantly increased survival of animals with medulloblastoma up to three-fold, in several different PDX models. Immunohistochemical assessment of tumours showed the combination treatment significantly decreased tumour proliferation and significantly induced apoptosis compared with controls. These data demonstrate our experimental approach has robustly identified effective new therapies for paediatric medulloblastoma, and our findings strongly suggest CHK1/2 inhibitors have promising potential to improve treatments for this disease. Neuro-Oncology 18:iii97–iii122, 2016. doi:10.1093/neuonc/now076.71 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Abstract #5257: ADP-Glo: An Ideal approach to monitor the activity of protein kinases and beyond
Authors: Said Goueli, Marina Zdanovskaia, Hicham Zegzouti
Journal: Cancer Research (2009)

Because of its versatility (all types of substrates), robustness (Z\#8217;>0.8), rapid performance, and its ease of use, the luminescence based Kinase GloTM assay platform have gained wide acceptance in many drug screening programs for protein kinase inhibitors. The new ADP Glo assay maintains all the positive features of kinase Glo. It is universal, applicable to all kinds of kinase substrates regardless of their nature with no prior modification (peptides, protein, polymer, lipids, and sugars). In stead of measuring ATP depletion, ADP-Glo monitors ADP production. It detects ADP at early stages of enzyme reactions with very high signal to background (SB) ratio. It can be run at wide range of ATP concentrations (low micromolar to millimolar), is sensitive to low ADP concentrations, and it can be carried out in high density plate formats. The assay is robust as is indicated by the high Z\#8217; values (over 0.8), homogenous, does not require antibodies or custom synthesized substrates, and is ideal to search for optimal substrates in a collection of peptides, proteins, lipids in one assay format and to screen for ATP competitive and Non competitive inhibitors. Because of the high dynamic range and more importantly, the high SB values at low % ATP to ADP conversion, the assay allows the use of low amount of enzyme during high-throughput screenings. ADP-Glo assay is applicable to all types of kinases, ATPases and many other ADP producing enzyme reactions.  Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 5257.
Soundings: Dear email correspondent
Authors: James Owen Drife
Journal: BMJ (2004)

Thank you very much for writing. I hope that you will not think me discourteous if I respond with this generic reply. Despite my best efforts it has become impossible to write individually to everyone who is kind enough to get in touch with me by email. Unfortunately neither the NHS trust nor the university is willing to provide me with an electronic secretary and both are now urging me to take a little time away from my desk and undertake some clinical or educational activity.

Firstly, may I offer my condolences. It must have been a great shock to lose your relative in such tragic circumstances. It is indeed rare for a private jet to encounter a flock of ostriches at 10 000 feet over impenetrable jungle and it is desperately sad that your relative's $300m is languishing in the Bank of Chad instead of being distributed to the orphanages as he intended.

I must admit to feeling flattered that God has told you that I am the only person in the world honest enough to access this money and ensure that it reaches the orphans while keeping 15% for myself to cover administrative costs. I had no idea that God held me in such esteem. Normally I would, of course, defer to His commands, but on this occasion the only authority capable of challenging Him—the Inland Revenue—has, alas, forbidden me to do so.

Secondly, I appreciate your offer of unlimited supplies of sildafenil at low, low prices. Many thanks for letting me know about the new soft tablets (is this the best name for them, I wonder?). I was a little concerned that you and so many others are aware of my shortcomings, but I have talked things over with my wife and we both feel that we are already very busy, particularly now that we have joined our local golf club. Can you tell us whether Viagra might improve my swing?

Finally, thank you for the guidelines that your personal assistant has just cascaded to me. The one on modernising overshoe disposal was a particular delight and, if I may say so, your use of bullet points on page 72 was masterly. It is a great advance to receive such documents electronically. In the old days, opening envelopes wasted so much of our precious time.
Tourette's disorder in a set of reared-apart triplets: genetic and environmental influences
Authors: N L Segal, M W Dysken, T J Bouchard, N L Pedersen, E D Eckert, L L Heston
Journal: American Journal of Psychiatry (1990)

Tourette's disorder was diagnosed in triplets reared apart from early infancy and reunited as adults. These data, combined with data on other family members, support the findings of research studies that have demonstrated genetic influences on Tourette's disorder.
Prolongation of the Lifespan of Mice With Advanced Leukemia (L1210) by Treatment With Halogenated Derivatives of Amethopterin
Authors: Abraham Goldin, Stewart R. Humphreys, John M. Venditti, Nathan Mantel
Journal: JNCI Journal of the National Cancer Institute (1959)

Studies were conducted on the influence of 4 halogenated derivatives of amethopterin in increasing the lifespan of mice with systemic leukemia (L1210). Amethopterin was employed as a standard. 3′-Bromoamethopterin appeared to be moderately more effective than amethopterin, but not as effective as 3′-chloroamethopterin. The latter yielded increases in median survival time 13 to 34 percent greater than those observed with amethopterin. The dihalogenated derivatives 3′-bromo-5′-chloroamethopterin and 3′,5′-dichloroamethopterin were extremely effective in this system. Both drugs were capable of extending the median survival time of the mice for the full period of treatment (90 days) and beyond, even when treatment was initiated only several days before death of controls. Some of the animals were still alive after 6 months and were presumably cured. The fact that some of these mice did not accept reinoculation of the leukemia suggests that they may have become immune. The antileukemic action of the halogenated derivatives may be reversed by concomitant administration of citrovorum factor. The implications of the data are discussed with respect to therapy and underlying mechanism.
Umana
Authors: Dean Gianakos
Journal: Annals of Internal Medicine (1995)

On Being a Doctor1 November 1995UmanaDean Gianakos, MDDean Gianakos, MDLynchburg Family Practice Residency Lynchburg, VA 24501Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-123-9-199511010-00016 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail I can talk to Umana about everything.“Death? Yes, what would you like to know, doctor? Am I afraid? Am I religious? God? Doctors? Words heal, doctor. What more would you like to know?”“I can barely see. The prednisone has worn out my eyes. I raise my arms and I get short of breath. The oxygen hose irritates my nose, but enough about me—how are you? Really, how are you? You help me so much, you really do. I like a doctor to whom I can talk. How is your practice? What do you think about health care reform?”... Author, Article, and Disclosure InformationAffiliations: Lynchburg Family Practice Residency Lynchburg, VA 24501Corresponding Author: Dean Gianakos, MD, Lynchburg Family Practice Residency, 2097 Langhorne Road, Lynchburg, VA 24501. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1995Volume 123, Issue 9Page: 730KeywordsDustHealth careHeart rateKneesMemoryMorphineNursesOxygenPainTouch Issue Published: 1 November 1995 CopyrightCopyright © 1995 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Clinical characteristics of aquagenic pruritus in patients with myeloproliferative neoplasms
Authors: C. Le Gall‐Ianotto, E. Brenaut, M. Gouillou, K. Lacut, E. Nowak, A. Tempescul, C. Berthou, V. Ugo, J.L. Carré, L. Misery, J.C. Ianotto
Journal: British Journal of Dermatology (2016)

Aquagenic pruritus (AP) is a diffuse itching sensation that develops immediately after water contact without any visible skin changes. AP is classically associated with polycythemia vera (PV), a BCR-ABL1-negative myeloproliferative neoplasm (MPN), and can precede the diagnosis of the disease1,2. Alternatively, AP can be drug-induced or associated with various disorders (e.g., myelodysplastic syndrome, hypereosinophilic syndrome, and juvenile xanthogranuloma)3,4.

This article is protected by copyright. All rights reserved.
Medical practice without antianxiety drugs
Authors: M H Keeler, R L Mccurdy
Journal: American Journal of Psychiatry (1975)

The benzodiazepines and hydroxyzine were removed from a statewide Medicaid pharmacopeia. Barbiturate sedatives, hypnotic and antipsychotic medication, and tricyclic antidepressants remained available, but no substitution was made for about two-thirds of the deleted ataractic medications. The authors conclide that most physicans regard ataractics as unique and do not use them interchangeably with the other drugs.
On Committees
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1976)

The marks of selfness are laid out in our behavior irreversibly, unequivocally, whether we are assembled in groups or off on a stroll alone. Nobody can be aware of the unique immunologic labels of anyone else, outside a laboratory, nor can we smell with any reliability the pheromonal differences among ourselves. So, all we have to go by is how we walk, sound, write letters, turn our heads. We are infallible at this. Nobody is really quite like anyone else; there are reminders here and there, but no exact duplicates; we are four billion unique individuals.Thus, when committees gather, . . .
Two cases of variant Creutzfeldt-Jakob disease reported in Spain in 2007 and 2008
Authors: J de Pedro Cuesta
Journal: Eurosurveillance (2008)

In 2005, the first case of variant Creutzfeldt-Jakob disease (vCJD) was reported in Spain, in a woman born in 1978 with clinical onset of symptoms in 2004 [1]. She subsequently died in 2005.
Retrospective Comparison Of Autologous Transplantation Results Of Decreased MNC Viability Graft Cases (n=52) To Good Viability Graft Cases (n=306), a Single Centre Experience
Authors: Mariann Szarvas, Gabriella Kovács, Zita Korondán, Peter Batar, Attila Kiss, László Rejtö, Gyula Reményi, Róbert Szász, László Váróczy, Árpád Illés, Miklós Udvardy
Journal: Blood (2013)
Effect of Antigen Density on Complement-Mediated Lysis, T-Cell-Mediated Killing, and Antigenic Modulation
Authors: M Glaser, R B Herberman
Journal: JNCI Journal of the National Cancer Institute (1974)

Immunoregulatory globulin, an α-globulin-rich fraction isolated from normal human plasma, inhibited the in vitro proliferative response of immune W /Fu rat lymphocytes to mitomycin C-treated syngeneic lymphoma cells (C58NT)D, induced by Gross virus. However, since no elevated levels of α-globulins were found in tumor-bearing rats compared to normal rats, the function of α-globulin in the suppression of the host's response to cancer remains to be elucidated.
Further Studies on Metabolic Changes in Patients with Gastric Cancer&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: F. Homburger, M. D., Nelson F. Young, Ph. D., Aurelia Potor, M. D., Jack B. Trunnell, M. D., Benedict J. Duffy, Jr., M. D., Mary L. Petermann, Ph. D., C. P. Rhoads, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Further Studies on Metabolic Changes in Patients with Gastric Cancer Get access F. Homburger, M. D., F. Homburger, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nelson F. Young, Ph. D., Nelson F. Young, Ph. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Aurelia Potor, M. D., Aurelia Potor, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jack B. Trunnell, M. D., Jack B. Trunnell, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Benedict J. Duffy, Jr., M. D., Benedict J. Duffy, Jr., M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary L. Petermann, Ph. D., Mary L. Petermann, Ph. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar C. P. Rhoads, M. D. C. P. Rhoads, M. D. Department of Clinical Investigation of the Sloan-Kettering, Institute for Cancer Research, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 489–496, https://doi.org/10.1093/jnci/10.2.489 Published: 01 October 1949
Fix It!
Authors: James R Webster
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LG-35LOW GRADE GLIOMAS (LGG) IN INFANTS - ONE INSTITUTION EXPERIENCE
Authors: Agnieszka Brozyna, Monika Drogosiewicz, Ewa Swieszkowska, Marta Perek-Polnik, Iwona Filipek, Wieslawa Grajkowska, Elzbieta Jurkiewicz, Pawel Daszkiewicz, Bozenna Dembowska-Baginska
Journal: Neuro-Oncology (2016)
A review of 125 cases to determine the risk of myelodysplasia and leukemia in pediatric neutropenic patients after treatment with recombinant human granulocyte colony-stimulating factor [letter]
Authors: S Imashuku, S Hibi, F Nakajima, T Mitsui, S Yokoyama, S Kojima, T Matsuyama, T Nakahata, K Ueda, I Tsukimoto
Journal: Blood (1994)
Affinity modulation of the platelet integrin alpha IIb beta 3 by alpha- chymotrypsin: a possible role for Na+/Ca2+ exchanger
Authors: M Shiraga, Y Tomiyama, S Honda, H Kashiwagi, S Kosugi, M Handa, Y Ikeda, Y Kanakura, Y Kurata, Y Matsuzawa
Journal: Blood (1996)
F-18 FDG Positron Emission Tomography in Primary Breast Non-Hodgkin’s Lymphoma
Authors: SIEMA M. BAKHEET, RAZAN BAKHEET, ADNAN EZZAT, ASMAH TULBAH, ASAF DURAKOVIC, SARWAT HUSSAIN
Journal: Clinical Nuclear Medicine (2001)

A 50-year-old woman had an irregular, mobile, firm right breast mass that became progressively larger in the past 3 months that measured 18 × 15 cm at the time of examination. She had no nipple discharge or skin changes. A 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography (FDG PET) showed a ring-shaped breast uptake consisting of high peripheral glycolytic activity and a cold center most likely representing necrosis or hemorrhage despite the absence of a history of trauma, surgical intervention, chemotherapy, or radiation to the breast. Whole-body images did not show any evidence of lymph node involvement or distant metastases. These results were confirmed by computed tomography of the chest, abdomen, and pelvis. Cytologic examination of a fine-needle aspiration of the breast mass showed diffuse large B-cell, intermediate grade, non-Hodgkin’s lymphoma. Although it occurs infrequently, primary breast lymphoma should be considered in patients with a breast mass that shows a ring-shaped FDG uptake. A PET scan, in contrast to other imagining techniques, offers the advantage of screening the entire body, excluding the presence of metastases, and confirming the primary origin of the breast lymphoma.
The epidemiology of meningococcal disease in England and Wales, 1996 and 1997
Authors: M E Ramsay, M Collins, M Rush, E Kaczmarksi
Journal: Eurosurveillance (1997)

Surveillance of meningococcal infection in England and Wales relies on three sources of data. Doctors are required by statute to notify clinically diagnosed cases of meningococcal meningitis and, since 1989, cases of meningococcal septicaemia (in the abse