tbuckley/cabot-search huggingface dataset:
AB0692 Radiographic Damage in A Group of Patients with Axial Spondyloarthritis: Table 1
Authors: E. Toniolo, A. Laiz, P. Moya, C. Díaz-Torné, I. Castellvi, C. Geli, M. Sarmiento, A.M. Millán, J.M. Llobet
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Recent studies in the field of axial spondyloarthropathies (SpA-ax) have shown a group of patients with chronic lower back pain without evidence of radiographic damage (non-radiographic axial spondyloarthritis). Currently, data is lacking that would confirm whether it is an early stage of the disease or a group of SpA-ax that is different, in which time of progression and radiographic damage show no relationship. <h3>Objectives</h3> Describe our cohort of patients diagnosed with radiographic axial spondyloarthritis. Assess whether those with both sacroiliac and spinal radiographic involvement have a longer duration of the disease and the relationship between this most-affected group and the different items that constitute the ASAS criteria for SpA-ax. <h3>Methods</h3> All patients diagnosed with SpA-ax by ASAS or NY criteria, who were seen in a monographic consultation of spondyloarthritis of our center between January 2012 and December 2013, were reviewed. Only those with sacroiliitis of grade II or higher were included; patients who did not have spinal radiographs were excluded. The following clinical and laboratory variables were collected from clinical history: age, sex, duration of disease, inflammatory back pain, arthritis, enthesitis, uveitis, dactylitis, psoriasis, inflammatory bowel disease, positive response to NSAIDs, family history of SpA, HLA-B27 and elevated CRP. The presence of 3 or more syndesmophytes in the dorsal and/or lumbar region was considered as spinal involvement. For statistical analysis, student9s t-test, chi-square test or Fisher9s exact test were performed where applicable. <h3>Results</h3> Of the 72 patients diagnosed with SpA-ax, 58 met the inclusion and exclusion criteria. The mean age of the study patients was 53.69 years and 69% were men. The mean disease duration was 19.48 years and 36 patients had spinal involvement. Only the age of patients, the sex and the duration of the disease showed significant results regarding the structural damage (see table). <h3>Conclusions</h3> In our cohort, patients with more severe radiographic involvement were those of a longer disease duration and an older age, with a predominance of men. No significant differences for the remaining assessed variables were found, including signs of inflammation and HLA-B27, which were similar in both groups of patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4483
Le traitement des sténoses pancréatiques réfractaires par prothèse métallique couverte peut-il se substituer au calibrage conventionnel par prothèse plastique dans la pancréatite chronique?
Authors: C Giacino, P Grandval, R Laugier
Journal: Endoscopy (2011)

Introduction: La douleur est la principale indication du traitement endoscopique des lésions canalaires dans la pancréatite chronique. Le but est de réduire l'hyperpression intra-parenchymateuse et l'ischémie en drainant le canal pancréatique principal. La plupart des sténoses bénignes du canal pancréatique principal siègent au niveau de la tête du pancréas et sont généralement traitées par la pose itérative de prothèse plastique. Cependant, ce drainage conventionnel se solde par un échec technique dans environ 15% des cas et les douleurs persistent dans environ 19% des cas, en raison de sténoses canalaires persistantes. Récemment par analogie avec l'arbre biliaire, les prothèses auto-expansives métalliques totalement couvertes ont été utilisées dans le traitement des sténoses canalaires bénignes réfractaires de la pancréatite chronique. Actuellement, seules de rares études chez l'homme ont été rapportées dans la littérature.
Abstract 1878: Acetyl coA carboxylase1 and its role in prostate cancer initiation and progression.
Authors: Amanda L. Davis, Kristen Scott, Yong Chen, Steven Kridel
Journal: Cancer Research (2013)

Abstract The alteration of cellular metabolic processes is a common event in the initiation and progression of several cancer types. One metabolic hallmark of cancer cells is an increase in de novo lipogenesis. The enzymes responsible for de novo fatty acid synthesis are overexpressed in cancer, suggesting that these enzymes may be appropriate targets in efforts to inhibit or treat disease. Specifically, Acetyl CoA Carboxylase 1 (ACC1), the cytosolic enzyme that catalyzes the rate limiting step of de novo fatty acid synthesis through the ATP and biotin-dependent carboxylation of acetyl-CoA to malonyl-CoA, has received attention as a potential target for cancer treatment. Pharmacological inhibition and siRNA mediated knockdown of ACC1 has been shown to selectively kill prostate cancer cells in vitro by denying cells of adequate amounts of fatty acids needed to proliferate and survive. Although ACC1 has been implicated in cancer, its role has not been examined in a spontaneous model of cancer. To address this issue, we first generated mice with prostate-specific deletion of exon 22 of the Acetyl CoA Carboxylase 1 (ACCL/L) gene by breeding with Probasin-Cre mice. Loss of ACC1 activity did not appear to affect prostate function as survival, prostate weight, histology, and breeding was similar between ACCL/L Cre+ and ACCL/L Cre− mice. To determine the role of ACC1 in prostate cancer, the ACC+/L mice were crossed with PtenL/L; Cre+ mice. To our surprise, ACC1 activity was not required for prostate cancer development or progression in vivo, despite its apparent requirement in vitro. Total prostate weight and individual lobe weight did not differ among ACC+/L; PtenL/L; Cre+ mice, ACCL/L; PtenL/L; Cre+ mice and ACC1+/+; PtenL/L; Cre+ mice. These early studies suggest that ACC1 activity, and perhaps the fatty acid synthesis pathway, may not be required for prostate cancer development. The role of ACC1 in redox modulation, rescue of impaired de novo fatty acid synthesis by circulating and dietary fatty acid, and the potential compensation for ACC1 activity by ACC2 in prostate cancer are possible explanations for this unexpected phenotype. These results could have significant impact on the development and use of anti-cancer therapeutics that target the fatty acid synthesis pathway. Citation Format: Amanda L. Davis, Kristen Scott, Yong Chen, Steven Kridel. Acetyl coA carboxylase1 and its role in prostate cancer initiation and progression. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1878. doi:10.1158/1538-7445.AM2013-1878
SAT0291 Evaluation of Sleep Quality in Psoriatic Arthritis Patients
Authors: M. T. Duruöz, Z. Sari Sürmeli, Ü. Uçar, E. Topçu, E. Duruöz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Psoriatic arthritis (PsA) is an inflammatory arthritis associated with psoriasis (1). PsA and its associated psoriatic skin lesions have been found to lower the health-related quality of life, effecting physical functioning and psychosocial well-being (2). Impairment of sleep and quality of life are important symptoms in PsA. <h3>Objectives</h3> Assesment of sleep quality and its relation with quality of life in PsA patients. <h3>Methods</h3> 40 patients fulfilling Caspar criteria for psoriatic arthritis were selected for this study. Patients with malignancy, fibromyalgia syndrome and other systemic inflammatory rheumatic diseases were excluded. Various clinical data including patients' general health and pain assesment with visual analog scale (VAS), morning stiffness, duration of psoriasis and psoriatic arthritis were recorded. Sleep disturbance was evaluated with Pittsburgh Sleep Quality Index (PSQI). Quality of life was assessed with Psoriatic Arthritis Quality of Life (PSAQol) and Notthingham Health Profile (NHP). Maastricht Ankylosing Spondylitis <i>Enthesitis</i>Score (MASES) was used for evaluation of enthesitis. <h3>Results</h3> 40 patients (14 men, 26 women) were recruited into this study. The mean age of patients was 46,06 years and the median disease duration was 9 months. Mean score for PSOI was 5,66±3,66. 44,8 % of patient were calssified to be poor sleepers (PSOI&gt;5). No significant correlations could be found between PSQI and VAS for pain, VAS for general health, disaese duration, morning stiffness, PASI and MASES scores. Howewer, there was a significant correlation between PSQI scores and NHP total score (p=0,001, r=0,610) and PsAQoL score (p=0,029, r=0,477). There was a statistically significant positive correlation between PsAQoL score and VAS for pain scores (p=0,002, r=0,552); with VAS for general health scores (p=0,010, r=0,471) and with MASES (p=0,001, r=0,653). There was no significant correlation between PSAQoL and erytrhocyte sedimentation rate, PASI, duration of psoriatic arthritis, duration of psoriasis <h3>Conclusions</h3> Sleep quality in PsA patients has good correlation with quality of life. Disease duration, severity of pain, skin leisons and entesitis did not seem to interfere with sleep quality for PsA. Treatment strategies in PsA should includes not only arhritis and skin lesions but also sleep therapies to increase the quality of life of patients. <h3>References</h3> Duffin K.C., Wong B., Horn E, J., Krueger G. G. Psoriatic arthritis is a strong predictor of sleep interference in patients with psoriasis. J Am Acad Dermatol.2009;60(4):604-608. Kwok T. and Pope J. E., Minimally Important Difference for Patient-reported Outcomes in Psoriatic Arthritis: Health Assessment Questionnaire and Pain, Fatigue, and Global Visual Analog Scales, J Rheumatol 2010;37;1024-1028. <h3>Disclosure of Interest</h3> None Declared
Genetic Tests Could Aid Diagnosis, Treatment
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Genetic Tests Could Aid Diagnosis, Treatment Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 12, 17 August 1988, Pages 889–890, https://doi.org/10.1093/jnci/80.12.889 Published: 17 August 1988
P01.06 * HIF-1 AND HIF-2 AS POSIBLE NEW TARGETS IN THE TREATMENT OF VON HIPPEL-LINDAU DISEASE HEMANGIOBLASTOMAS
Authors: D. Vinas, G. Serrano-Heras, A. B. Perona-Morata, P. De Andres, J. Fortes, T. Segura, J. M. De Campos
Journal: Neuro-Oncology (2014)

BACKGROUND: Von Hippel-Lindau disease (VHL)is a genetic condition predisposing to the development of multiple specific tumors, mainly CNS and retinal hemangioblastomas and clear cell renal cancer (CCRC). Protein pVHL, codified by VHL gene, is an important component of the functional complex responsible for degrading hypoxia inducible factors (HIF1alpha and HIF2alpha). In hypoxic condition, or in absence of functional protein VHL, an accumulation of HIF results, and thus an activation of gene transcription related to angiogenesis, and cell proliferation and survival. A number of works supports a role of unregulated amplification of HIF activity and of proteins codified by HIF-inducible genes as oncogenic, promoting the development of some tumors as CCRC, in VHL patients. Their role is still unknown in the appearance of hemangioblastomas, as there is no information about the level of synthesis and transcription of HIF proteins in these tumors. The main objective of our study is to determine the levels of proteins HIF-1alpha and HIF-2alpha and the eventual associated VEGF variation. MATERIAL AND METHODS: Tissue from nine hemangioblastomas (cerebellar, spinal cord, brainstem, brain) resected from VHL patients was obtained immediately after each tumor resection, and cultured for growing. Six primary cultures were obtained, and analyzed by Flow Cytometry for cell population component evaluation and by Western-Blot in order to measure the levels of proteins HIF-1alpha, HIF-2alpha and of VEGF. RESULTS: Cellular characterization of the 6 primary cultures obtained from 9 hemangioblastomas has shown they are composed of stromal cells (more than 50% CD99 + cells), endothelial cells (15% CD34+ cells), and pericytes (30% NG2+ cells). In the study, 25-40% of stromal cells, 3-15% of endothelial cells, and 5-30% of pericytes had increased levels of HIF-1alpha and HIF-2alpha. Furthermore, Western-Blot assay showed a very high concentration of VEGF in hemangioblastoma cells, 2 to 4 times more than in cell lines characterized by over-expression of VEGF (lines derived from colon cancer and from retinal pigmentary epithelium). No correlation of HIF expression in culture and cell proliferation in the original tumor (Mib-1) has been found. CONCLUSIONS: Our results show that proteins HIF-1alpha and HIF-2alpha are over-expressed in hemangioblastomas from VHL patients, suggesting a role of these proteins in the development and growth of these tumors. The results support the exploration of possible treatments directed to inactivate HIF1alpha and HIF-2alpha proteins as new targets, in order to control de proliferation of hemangioblastomas in these patients.
Increased FDG Uptake of the Bone Marrow Mimicking Malignancy in a Patient of Eosinophilia Secondary to Sparganum mansoni Infection
Authors: Aisheng Dong, Yang Wang, Lei Gao, Changjing Zuo
Journal: Clinical Nuclear Medicine (2013)

Secondary eosinophilia is usually associated with parasitosis in Third World countries. We present a case of eosinophilia secondary to Sparganum mansoni infection showing multifocal FDG uptake in the axial bones mimicking malignancy. Bone marrow aspirations and biopsy revealed remarkable proliferation of eosinophils which may be related to the increased FDG uptake. This case indicates that secondary eosinophilia associated with parasitosis may be one cause of diffuse FDG uptake in the bone marrow.
AB0483 The Disturbance of Carbohydrate Metabolism in Rheumatologic Patients after Glucocorticoid Pulse-Therapy
Authors: G. Nurullina, F. Valeeva
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The duration and doses of glucocorticoids (GC) are significant prognostic factors of glucose intolerance and diabetes in rheumatologic diseases <h3>Objectives</h3> To evaluate the influence of GC pulse-therapy (PT) on carbohydrate metabolism in patients with rheumatologic diseases. <h3>Methods</h3> The study included 27 patients (men – 4, women - 23) with different rheumatologic diseases (lupus erythematosus – 20, systemic vasculitis - 7) aged 18-68 years (mean age 42,3±14,43) and duration of disease from six months to 12 years (mean 3,55±3,36). GC PT consisted of intravenous infusion of 600-1000 mg of prednisone a day for 3 consecutive days (total dose for a course 1800-3000 mg/day). We performed the evaluation of glucose levels in all patients before the start of PT and at 2, 4, 6,10, 24, 48 and 72 hours after the infusion, and in patients with abnormal blood glucose level at 72 hours after the infusion the evaluation was continued until normalization of blood glucose levels. After the course of PT all patients performed an oral glucose tolerance test (OGTT). Patients with normal OGTT were included in the first group (blood glucose less than 7,8 mmol/l 2 hours after oral administration of 75 g of glucose). Twenty patients aged 18-54 (mean age 38,0±2,8) years were included in the first group. Patients in the second group had blood glucose levels above 7,8 mmol/l after the OGTT. This group consisted of 7 patients aged 44- 61 years (mean age 52,5±8,5). <h3>Results</h3> All patients included in the study demonstrated an increase of blood glucose levels after the course of PT, reaching maximum 4 hours after the start of the infusion – in the first group levels reaching 11,2±0,92 mmol/l, in the second group 21,95±0,25 mmol/l (p&lt;0,05). Blood glucose normalization in the first group was observed during 1,75±0,18 days (1 to 3 days), whereas in the second group during 4,0±1,0 (3 to 5 days) (p&lt;0,05). During OGTT mean fasting blood glucose level in the first group was 4,59±0,11 mmol/l, in the second group – 5,95±0,45 (p&lt;0,05); 2 hours after the glucose load – 6,0±0,21 mmol/l and 10,0±1,5 mmol/l respectively (p&lt;0,05). <h3>Conclusions</h3> GC PT in rheumatologic patients is associated with abnormal blood glucose levels, indicating the presence of glucose intolerance. High blood glucose during PT and long period until normalization of blood glucose levels are prognostic factors of carbohydrate metabolism disturbances. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4323
RARE VARIANT ASSOCIATION STUDY FINDS NO LARGE-EFFECT, LOW-FREQUENCY VARIANTS FOR AORTIC AND MITRAL VALVE CALCIFICATION
Authors: Andreas C. Mauer, Shih-Jen Hwang, Jie Yao, Albert V. Smith, George Thanassoulis, Matthew Budoff, Jerome Rotter, Sekar Kathiresan, Vilmundur Gudnason, Wendy Post, Christopher O’Donnell
Journal: Journal of the American College of Cardiology (2015)
P203 Correlation of Nijmegen score and hospital anxiety/depression (HAD) score in dysfunctional breathlessness
Authors: A. Dwarakanath, V. Davison, C. M. Taylor, A. G. Fennerty
Journal: Thorax (2011)

<h3>Introduction</h3> Dysfunctional Breathlessness has an incidence of about 10% among the general population and can often coexist with other chronic cardio respiratory illness. Patients often have a degree of anxiety or depression and may pose a diagnostic and therapeutic challenge. Nijmegen questionnaire is suitable as a screening tool for early detection and also as an aid in diagnosis and therapy planning. <h3>Aim</h3> To test the correlation between the Nijmegen score and the hospital anxiety/depression score in patients diagnosed with dysfunctional breathlessness. <h3>Method</h3> The diagnosis was made on the basis of exclusion with a normal clinical examination, lung function and echocardiogram, or with symptoms disproportionate to measurements of severity of their respiratory illness. The physiotherapist further assessed patients with particular regard to their breathing pattern and the Nijmegen (Ni) score, with a score over 23 being regarded as diagnostic. Consecutive patients referred to the clinic over 24 months were reviewed. The following parameters were analysed- demographics, underlying respiratory illness, breathing and sleep pattern, Nijmegen score (Pre and Post Intervention), HAD scores and the interventional modalities. <h3>Results</h3> 51 patients (males 20, females 31) were assessed. The mean age at presentation was 60.2 (range 20–84). 26/51 patients had chronic cardio respiratory illness. 28/51 patients had an abnormal breathing pattern, the most common being frequent sighing. 23/51 patients reported abnormal sleep pattern, frequent awakening being the commonest. 37 patients (males 17, females 20) had a pre intervention Ni score over 23 (mean 29, range 23–42). Interventions included patient education, cognitive–behavioural therapy, breathing exercises and training in a physiotherapist led clinic. The interventional period was 6 weeks and post 6 weeks the Nijmegen score fell below the diagnostic threshold in 29/37 patients (mean reduction 14, range 3–22, p value&lt;0.001). HAD scores was used to assess the degree of mood impairment and there was no linear correlation (Pearson correlation) (Abstract P203 table 1) with the pre intervention Nijmegen score. <h3>Conclusion</h3> There was no correlation between the Nijmegen score and the hospital anxiety/depression score in patients with dysfunctional breathlessness. A physiotherapy led dysfunctional breathlessness clinic was able to improve symptoms in 78% of the referred cases as measured by Ni score.
Specialty Pharmaceuticals for Hyperlipidemia — Impact on Insurance Premiums
Authors: Kevin A. Schulman, Suresh Balu, Shelby D. Reed
Journal: New England Journal of Medicine (2015)

Interview with Dr. Kevin Schulman on the recent approval of two PCSK9 inhibitors and what their prices could mean for insurance premiums. (09:12)Download The approval of PCSK9 inhibitors with broad indications sets the practice of cardiology on a collision course with specialty pharmaceutical pricing models that were previously reserved for drugs that benefited relatively limited patient populations.
Adenosine deaminase type 2 deficiency masquerading as GATA2 deficiency: Successful hematopoietic stem cell transplantation
Authors: Amy P. Hsu, Robert R. West, Katherine R. Calvo, Jennifer Cuellar-Rodriguez, Mark Parta, Susan J. Kelly, Nancy J. Ganson, Michael S. Hershfield, Steven M. Holland, Dennis D. Hickstein
Journal: Journal of Allergy and Clinical Immunology (2016)
Case 19-2005
Authors: Ann Y. Kao, Rus Munandar, Stephen L. Ferrara, David M. Systrom, Robert L. Sheridan, Sydney S. Cash, Edward T. Ryan
Journal: New England Journal of Medicine (2005)

A 17-year-old Indonesian girl was swept up by a tsunami that followed a large earthquake. She aspirated salt water and mud but did not lose consciousness. Two days later, a cough developed; two weeks after the tsunami, she had headache, nausea, and vomiting. One week later, right-sided hemiparesis and aphasia developed, which worsened after several weeks in local hospitals. She was transferred to the U.S. Naval Ship Mercy for evaluation and treatment.
Left Main Coronary Artery Stent Migration
Authors: Sasikanth Adigopula, Ali Nsair
Journal: New England Journal of Medicine (2015)

A 22-year-old woman with primary pulmonary hypertension presented with displacement of stents that had been implanted in the left main coronary artery and had migrated into the aorta. She had been referred to our center for evaluation for lung transplantation.
The Comparison of Asthma Control Judgment Based on Japanese Guidelines for Asthma, GINA, EPR3, and ACT
Authors: H. Nagase, N. Sugimoto, Y. Nakase, A. Kamiyama, H. Yoshihara, M. Kuramochi, H. Tashimo, H. Arai, N. Suzuki, M. Yamaguchi, K. Ohta
Journal: Journal of Allergy and Clinical Immunology (2012)
Gun Ownership as a Risk Factor for Homicide in the Home
Authors: Arthur L. Kellermann, Frederick P. Rivara, Norman B. Rushforth, Joyce G. Banton, Donald T. Reay, Jerry T. Francisco, Ana B. Locci, Janice Prodzinski, Bela B. Hackman, Grant Somes
Journal: New England Journal of Medicine (1993)

It is unknown whether keeping a firearm in the home confers protection against crime or, instead, increases the risk of violent crime in the home. To study risk factors for homicide in the home, we identified homicides occurring in the homes of victims in three metropolitan counties.
When It Comes to Trials, Do We Get What We Pay For?
Authors: P.J. Devereaux, Salim Yusuf
Journal: New England Journal of Medicine (2013)

Randomized clinical trials supported by government agencies are critical for advancing knowledge about a large number of interventions (e.g., generic therapies, health system strategies, and surgery) that are relevant to clinical practice and public health. There is a need, however, for timely publication of trial results, to allow health care providers to use the information promptly.In this issue of the Journal, Gordon et al.1 report a thought-provoking study of 244 trials funded by the National Heart, Lung, and Blood Institute. Although data collection for these trials was completed between January 1, 2000, and December 31, 2011, the results of . . .