Metabolically Healthy Obesity and Development of Chronic Kidney Disease
Authors: Fatima Cody Stanford, W. Scott Butsch
Journal: Annals of Internal Medicine (2016)

Letters15 November 2016Metabolically Healthy Obesity and Development of Chronic Kidney DiseaseFatima Cody Stanford, MD, MPH, MPA and W. Scott Butsch, MD, MScFatima Cody Stanford, MD, MPH, MPAFrom Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.Search for more papers by this author and W. Scott Butsch, MD, MScFrom Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0408 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Chang and colleagues (1) report that overweight and obesity are associated with an increased incidence of chronic kidney disease (CKD) in metabolically healthy young and middle-aged adults. As global obesity rates continue to climb (2), evaluating the substantial role that obesity plays in the development of such comorbidities as CKD is important. Obesity is a complex, multifactorial chronic disease, and the authors should consider several points before we are able to extrapolate their results and their potential effect on the greater population of persons with obesity.Previous studies have shown that persons who are overweight (body mass ...References1. Chang Y, Ryu S, Choi Y, Zhang Y, Cho J, Kwon MJ, et al. Metabolically healthy obesity and development of chronic kidney disease: a cohort study. Ann Intern Med. 2016;164:305-12. [PMID: 26857595]. doi:10.7326/M15-1323 LinkGoogle Scholar2. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:766-81. [PMID: 24880830] doi:10.1016/S0140-6736(14)60460-8 CrossrefMedlineGoogle Scholar3. Navaneethan SD, Schold JD, Arrigain S, Kirwan JP, Nally JV. Body mass index and causes of death in chronic kidney disease. Kidney Int. 2016;89:675-82. [PMID: 26880461] doi:10.1016/j.kint.2015.12.002 CrossrefMedlineGoogle Scholar4. Agarwal R, Bills JE, Light RP. Diagnosing obesity by body mass index in chronic kidney disease: an explanation for the “obesity paradox?”. Hypertension. 2010;56:893-900. [PMID: 20876448] doi:10.1161/HYPERTENSIONAHA.110.160747 CrossrefMedlineGoogle Scholar5. Cao X, Zhou J, Yuan H, Wu L, Chen Z. Chronic kidney disease among overweight and obesity with and without metabolic syndrome in an urban Chinese cohort. BMC Nephrol. 2015;16:85. [PMID: 26084279] doi:10.1186/s12882-015-0083-8 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0408. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoMetabolically Healthy Obesity and Development of Chronic Kidney Disease Yoosoo Chang , Seungho Ryu , Yuni Choi , Yiyi Zhang , Juhee Cho , Min-Jung Kwon , Young Youl Hyun , Kyu-Beck Lee , Hyang Kim , Hyun-Suk Jung , Kyung Eun Yun , Jiin Ahn , Sanjay Rampal , Di Zhao , Byung-Seong Suh , Eun Cheol Chung , Hocheol Shin , Roberto Pastor-Barriuso , and Eliseo Guallar Metabolically Healthy Obesity and Development of Chronic Kidney Disease Dustin J. Little , Wondaye T. Deressa , Maura A. Watson , and Christina M. Yuan Metabolically Healthy Obesity and Development of Chronic Kidney Disease Henry S. Kahn and Meda E. Pavkov Metabolically Healthy Obesity and Development of Chronic Kidney Disease Yoosoo Chang , Seungho Ryu , Juhee Cho , Roberto Pastor-Barriuso , and Eliseo Guallar Metrics Cited byTrends in Obesity and Metabolic Status in Northern and Southern China Between 2012 and 2020Weight Change and Development of Subclinical Carotid Atherosclerosis Among Metabolically Healthy Adults: A Cohort StudyDiscrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities 15 November 2016Volume 165, Issue 10Page: 742-743KeywordsBody mass indexChronic kidney diseaseMetabolic disordersMetabolic syndromeMorbidityObesityOverweightPhenotypesRacial and ethnic issuesYoung adults ePublished: 15 November 2016 Issue Published: 15 November 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...