tbuckley/cabot-search huggingface dataset:
A1.28 Neutrophilcard9 mediates autoantibody-induced autoimmune diseases
Authors: T Nemeth, C Sitaru, J Ruland, A Mócsai
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objectives</h3> CARD9 is a CARMA-like intracellular protein that is highly expressed in myeloid cells. We previously presented that CARD9 plays an important role in the development of experimental arthritis and autoimmune blistering skin disease in mice, likely by linking the Syk tyrosine kinase to chemokine production in innate immune cells. Here, we investigated whether CARD9 expression in neutrophils is required for the <i>in vivo</i> pathogenesis. <h3>Materials and methods</h3> Neutrophil-specific CARD9 deletion was achieved by crossing MRP8 promoter-driven Cre recombinase transgenic (MRP8-Cre) animals with Card9<sup>flox/flox</sup> mice (MRP8-Cre Card9<sup>flox/flox</sup> animals). The efficacy and specificity of lineage-specific deletion was analysed by Western-blot on neutrophil and macrophage cell lysates. Experimental arthritis was induced by a single intraperitoneal injection of K/BxN serum and was assessed by clinical scoring, ankle thickness measurements and by testing articular function. Epidermolysis bullosa acquisita was triggered by anti-collagen type VII antibodies. <h3>Results</h3> In contrast to the wild type animals, neutrophils of the MRP8-Cre CARD9<sup>flox/flox</sup> mice did not express CARD9, while their macrophages had normal levels of the protein. Neutrophil-specific CARD9 deletion caused a partial, but significant decrease in the clinical arthritis score, the ankle thickening and the articular dysfunction, which did not differ significantly from that seen in <i>Card9</i><sup>–/– </sup>animals. A similar phenomenon was observed in connexion with the autoimmune blistering skin disease as MRP8-Cre Card9<sup>flox/flox</sup> animals showed a substantial but incomplete reduction in inflammation, which was indistinguishable from the <i>Card9</i><sup>–/–</sup> phenotype. <h3>Conclusions</h3> CARD9 expression in neutrophils plays an important role in the development and progression of autoimmune arthritis and autoimmune blistering skin disease in mice, likely by controlling gene expression in these myeloid cells. <i>This project was supported by the János&nbsp;Bolyai Research Scholarship of the Hungarian Academy of Sciences.</i>
Persistent Gastroesophageal Reflux Induced during Prolonged Gastric Intubation
Authors: Richard Nagler, Howard M. Spiro
Journal: New England Journal of Medicine (1963)

PROLONGED gastric intubation may be a factor in the development of peptic esophagitis and stricture in some patients, but whether acid reflux into the esophagus is the primary mechanism is uncertain. A previous study utilizing cineradiographic technics showed no reflux of barium into the esophagus during short-term gastric intubation.1 In contrast, this study of simultaneously recorded intraluminal esophageal pressures and pH reports that gastric acid is refluxed and maintained in the distal esophagus during prolonged gastric intubation under certain conditions.Methods and ResultsThree water-filled polyethylene catheters, each with an internal diameter of 1.5 mm., were fastened together and sealed . . .
PTU-040 Five Year Outcomes For Patients Undergoing Endoscopic Therapy For Barrett’s Related Neoplasia From The United Kingdom’s Largest Single Centre Experience
Authors: RJ Haidry, M Banks, A Gupta, M Butt, M Rodriguez-Justo, M Novelli, L Lovat
Journal: Gut (2014)

<h3>Introduction</h3> The National Institute of Clinical Excellence (NICE) in the United Kingdom (UK) approved the use of Radiofrequency ablation (RFA) as minimally invasive endoscopic therapy for the treatment of Barrett’s Oesophagus related neoplasia as an alternative to surgery in 2010. These high risk patients carry a 40–60% risk of progressing to Osophageal Adenocarcinoma (OAC), survival from which is poor. Over the past 5 years combined endoscopic mucosal resection (EMR) and RFA have become the preferred intervention for the curative treatment of patients with BE related neoplasia. <h3>Methods</h3> We report prospective data from one of the UK’s largest academic tertiary centres for patients undergoing RFA for early neoplasia arising in BE between 2008–2013 at University College Hospital, London. Before RFA, visible lesions were removed by EMR. Patients then underwent RFA every 3 months until all visible BE was ablated or cancer developed (endpoints). Biopsies were taken at 12 months or when endpoints reached. Primary outcomes were clearance for dysplasia (CR-D) and BE and intestinal metaplasia (CR-IM) at 12 months. Long term durability for CR-D for those with favourable outcomes at 12 months was assessed. <h3>Results</h3> Two hundred patients have undergone RFA since 2007 at our centre. Of these 145 have completed treatment. Most are male (83%), mean age 69 years (range 44–91). Baseline histology HGD in 86% and IMC in 14%. Mean length BE segment prior to RFA 6cm (range 1–20). Ten per cent patients in our cohort underwent RFA for residual neoplasia after unsuccessful Photodynamic therapy (PDT). Prior to RFA treatment, 50% of patients had EMR for visible lesions. After 2–3 RFA treatments (range 1–6) over 12 months, 80% (116/45) patients had achieved CR-D and 65% CR-IM (94/145). Pre-treatment PDT, EMR or histology did not influence outcomes. Three patients (2.5%) progressed to invasive OAC at 12 months and in total 8 (7%) progressed at most recent follow up. At 5 years 95% of patients who had dysplasia clearance at 12 months remain disease free (median follow up 20 months, IQR 9–32). Kaplan Meir survival statistics demonstrate at 5 years after successful treatment 75% and 77% of patients are likely to remain free of dysplasia and IM respectively. <h3>Conclusion</h3> We report on the UK’s single largest prospective series to date of patients undergoing endoscopic therapy for BE related neoplasia. Our outcomes compare favourably with those published around the world and from within the UK patient registry. These patients are high risk and require vigilant follow up even after successful treatment as predicted recurrence can occur in up to 25% of cases. <h3>Disclosure of Interest</h3> None Declared.
MODELO PORCINO DE OBSTRUCCIÓN BILIAR MEDIANTE SOBRECLIP OVESCO® PARA EL ADIESTRAMIENTO EN TÉCNICAS DE DRENAJE GUIADAS POR ULTRASONOGRAFÍA ENDOSCÓPICA (USE)
Authors: L Pelayo, V Aguilar Urbano, N Alcaide Suárez, MT Herranz Bachiller, L Sancho del Val, R Ruiz-Zorrilla, P Díez-Redondo, C De la Serna Higuera, M Pérez-Miranda
Journal: Endoscopy (2012)

Introducción: Existe una demanda clínica creciente de procedimientos de drenaje guiados por USE. Estos procedimientos son técnicamente complejos y conllevan morbilidad. Su docencia y aprendizaje están todavía por definir. Objetivo: Desarrollar un modelo porcino de obstrucción biliar más simple, barato y asequible que la ligadura laparoscópica del colédoco. Evaluar su potencial para el adiestramiento en USE terapéutica. Material y método: Clipaje de la papila mayor mediante sobreclip Ovesco® en 16 animales (13 machos) con un peso medio de 33.06Kg. Gastroscopia con intubación secuencial por el mismo operador, sin y con Ovesco®. Comparación de éxito técnico con 2 exploradores expertos y 2 noveles y tiempo hasta identificar papila Vs tiempo de colocación Ovesco®. Seguimiento clínico, bioquímico y morfológico durante 8–10días para evaluar eficacia y complicaciones. Práctica de anastomosis bilio-entéricas USE guiadas usando ecoendoscopio lineal convencionales (n=13) y prototipo de visión frontal (n=10). Resultados: El Sobreclip Ovesco® se liberó con éxito en 15/16 animales. En un caso se liberó inadecuadamente. No hubo diferencias entre el tiempo hasta la identificación de la papila 460 segundos (158–892) y el tiempo para la liberación del Ovesco®, 575 segundos. Dos animales presentaron dolor abdominal: uno murió en 48 horas por perforación gástrica y otro presentó un absceso retroduodenal en la necropsia a los 10días. A los 3–4días, 14/15 animales presentaron hiperbilirrubinemia, valor total medio de 3.55mg/dL e incremento medio de 2.85mg/dL. En 4/4 en los que se practicó ecografía/laparoscopia, presentaron dilataciones de colédoco (>4mm), cístico y vesícula biliar. A los 8–10días todos mostraron dilataciones saculares del colédoco (>15mm) mediante USE, sólo 3/14 dilatación intrahepática. Se intentaron 23 procedimientos de drenaje (16 por operadores noveles), hepaticogastrostomía (n=3), coledocoduodenostomía (n=8) o colecistogastrostomía (n=12). Acceso USE y colangiografía en 23/23, las anastomosis sólo tuvieron éxito en 30.5%. Conclusión: La colocación del Sobreclip Ovesco® en la papila porcina proporciona un modelo de obstrucción biliar sencillo y útil para el adiestramiento en USE terapéutica.
P4-09-13: External Validation of Adjuvant! Online Breast Cancer Prognosis Tool. Improvement Is Still Needed.
Authors: D Hajage, Rycke Y De, M Bollet, A Savignoni, M Caly, J-Y Pierga, HM Horlings, de VjverMJ Van, A Vincent-Salomon, B Sigal, C Senechal, B Asselain, X Sastre, F Reyal
Journal: Cancer Research (2011)

Abstract Introduction: AdjuvantOnline is a web-based application designed to provide 10 years survival probability patients with breast cancer. Few validation studies have underlined some limitations, particularly an overestimation of the prognosis among certain subgroups of patients. Moreover, several predictors such as HER2 over expression status and proliferation markers have not been assessed in Adjuvant! original study. We provide the validation of AdjuvantOnline algorithm on two breast cancer datasets collected from two large European cancer centres, and we determined whether the accuracy of AdjuvantOnline is improved by others well known prognostic factors. Material and Methods: The French data set is composed of 456 women with early breast cancer, treated at the Institut Curie between 1995 and 1996. The dutch data set is composed of 295 women less that 52 years treated at the Netherlands Cancer Institute between 1984 and 1995. Agreement between observation and Adjuvant! prediction was checked by testing that the calibration slope was equal to 1. Logistic models were performed to evaluate whether risk factors adds significant prognostic information, including AdjuvantOnline a priori information as an offset. Results: Ten years survival status was known for 383 patients in the French data set and 247 patients in the Dutch data set. Adjuvant! prediction was globally well calibrated in the French data set (observed survival 86%, predicted survival 85%), but was overestimated in high grade, HER2 positive and Ki67 &amp;gt; 20% subgroups. HER2 status, Mitotic Index, Ki67 and treatment type were strongly associated with 10-year survival, even considering AdjuvantOnline a priori information. In the Dutch data set, the overall 10-year survival was overestimated by AdjuvantOnline (observed 66%, predicted 79%), particularly in patients less than 40 years old. Conclusion: AdjuvantOnline needs to be updated to adjust overoptimistic results in young and high grade patients, and should consider candidates, such as Ki67, HER2 and Mitotic Index. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-09-13.
Abstract LB-335: Retinoic acid regulates TRAIL-R1 expression through a retinoic acid receptor-dependent mechanism and enhances death receptor-induced apoptosis
Authors: Latha Dhandapani, Ping Yue, Suresh S. Ramalingam, Fadlo R. Khuri, Shi Yong Sun
Journal: Cancer Research (2010)

Abstract Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor 1 (TRAIL-R1) also known as death receptor 4 (DR4), is a death domain containing transmembrane receptor involved in TRAIL-mediated apoptosis. One biological function of retinoic acid (RA) among many others is to regulate apoptosis, in part through TRAIL induction. The current study reveals another novel mechanism by which RA modulates apoptosis. For the first time, we found that RA increased TRAIL-R1 expression in various types of human cancer cell lines; this effect could be abrogated by the transcriptional inhibitor actinomycin-D. Moreover, RA increased TRAIL-R1 mRNA level and transactivated its promoter. These data collectively indicate that RA induces TRAIL-R1 expression at the transcriptional level. We also found that RA-induced TRAIL-R1 expression could be abolished by some retinoic acid receptor (RAR) antagonists, whereas various RAR agonists upregulated TRAIL-R1 expression, suggesting that RA induces a RAR-dependent TRAIL-R1 expression. Importantly, we identified two putative RA responsive elements (RARE) named RARE-Pal17 (a palindrome separated by 17 bases) and RARE-DR11 (a direct repeat separated by 11 bases) in the 5′ flanking region of TRAIL-R1 gene. Deletion and mutation of RARE-DR11, but not RARE-Pal17, abrogated RA's effect on transactivation of TRAIL-R1 promoter. In agreement, ChIP assay detected only RARE-DR11 binding, but not RARE-Pal17 binding, in RA-treated cells. These data collectively indicate that the RARE-DR11 is an active one that is responsible for TRAIL-R1 gene transactivation by RA. Furthermore, RA, when combined with TRAIL or agonistic anti-TRAIL-R1 antibody, augmented apoptosis in cancer cells. Taken together, the current study provides compelling evidence that TRAIL-R1 is a RAR target gene and mediates modulation of death receptor-induced apoptosis by RA, thus highlighting a novel mechanism by which RA modulates apoptosis.(SSR, FRK and SYS are Georgia Cancer Coalition Distinguished Cancer Scholars. This study was supported by funds from the Georgia Cancer Coalition Distinguished Cancer Scholar, NIH Head and Neck SPORE P50 CA128613 and DOD VITAL awards) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-335.
Amiodarone-Induced Pulmonary Toxicity
Authors: B Olshansky
Journal: New England Journal of Medicine (1997)

Figure 1. Osteomyelitis of a toe developed in a 59-year-old man with diabetes, coronary artery disease, and a cardioverter–defibrillator, which had been implanted three years earlier. The infection, which was caused by group B streptococcus, spread to the cardioverter–defibrillator. Computed tomography of the chest revealed no abnormalities (Panel A). The grossly infected cardioverter–defibrillator and epicardial patches were removed, and the patient was treated with amiodarone at a dose of 400 mg per day. Two months later, cough and dyspnea developed and the partial pressure of oxygen plummeted. The measured diffusing capacity of carbon monoxide dropped below 20 percent of the . . .
Case 23-1997
Authors: Linda J. Heffner, Drucilla J. Roberts, Marvin Nanowitz
Journal: New England Journal of Medicine (1997)

Presentation of CaseA newborn girl was admitted to the intensive care unit because of premature birth and congenital ascites.The infant was born to a 27-year-old woman after a gestation of 28 weeks and 3 days. The pregnancy, which was the woman's first, was uneventful until the onset of lower abdominal pain three days before admission. An ultrasonogram at her local hospital showed the presence of fetal hydrops. An umbilical-blood specimen obtained percutaneously showed a fetal white-cell count of 2700 per cubic millimeter, a hematocrit of 31.3 percent, and a platelet count of 258,000 per cubic millimeter. A test . . .
Abstract 219: Glycosylation-dependent effect of CD109 on TGF-beta1 and EGF signaling in human glioblastoma cells
Authors: Yoshiki Murakumo, Masahide Takahashi
Journal: Cancer Research (2012)

Abstract CD109, a glycosylphosphatidylinositol-anchored cell surface glycoprotein, is a negative regulator of TGF-beta1 signaling, whose expression is predominantly detected in squamous cell carcinomas of esophagus, lung, uterus and oral cavity. In the Northern blot analysis using various human tumor cell lines, we found CD109 expression in cell lines derived from human glioblastomas, however, the significance of CD109 in glioblastoma cells has not yet been elucidated. Here, we present the glycosylation-dependent effect of CD109 on TGF-beta1 and EGF signaling in glioblastoma cells. SK-MG-1 cells overexpressing CD109 exhibited downregulation of Smad2 phosphorylation after TGF-beta1 stimulation and upregulation of EGFR and ERK1/2 phosphorylation after EGF stimulation, indicating that CD109 is involved in not only negative regulation of TGF-beta1 signaling but also positive regulation of EGF signaling. However, in other glioblastoma cell lines, U251MG and MG178, CD109 overexpression showed no significant effect on TGF-beta1 and EGF signaling. CD109 overexpression also enhanced cell proliferation and migration in SK-MG-1 cells, but not in the other two cells. Western blot analysis showed that molecular mass of CD109 of SK-MG-1 cells was a bit high compared with those of the other two cell lines, and deglycosylation analysis revealed enhanced glycosylation of CD109 in SK-MG-1 cells. TGF-beta1 signal in U251MG and MG178 was suppressed when the medium with hyperglycosylated soluble form of CD109 was used for TGF-beta1 stimulation. Our results suggest the glycosylation-dependent effect of CD109 on cell biology of glioblastoma cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 219. doi:1538-7445.AM2012-219
P302 METADOXINE SIGNIFICANTLY IMPROVES SURVIVAL IN ABIC CLASS B PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS WHEN ADDED TO PENTOXIFYLLINE OR PREDNISONE
Authors: F. Higuera-de la Tijera, A.I. Servin-Caamaño, A.E. Serralde-Zuñiga, J. Cruz-Herrera, E. Pérez-Torres, J.M. Abdo-Francis, J.L. Pérez-Hernández, F. Salas-Gordillo
Journal: Journal of Hepatology (2014)
Mortality of Persons with Photofluorograms Suggestive of Cardiovascular Disease
Authors: George W. Comstock
Journal: New England Journal of Medicine (1953)

THE advent of photofluorography has made possible the radiologic screening of the chests of millions of persons each year. Although this method has been largely applied to tuberculosis case finding, many cardiovascular abnormalities have also been detected by this procedure. Since diseases of the cardiovascular system are responsible for an increasingly large number of deaths each year, efforts have been made to determine the potential usefulness of chest photofluorography as a means of detecting persons with cardiovascular disease, with the assumption that patients found in routine surveys might be benefited more by appropriate treatment than those seeking medical care because . . .
AB0244 Retrospective study on effects of ramadhan month fasting on rheumatoid arthritis patients
Authors: V. X. Su, N. A. Azahar, Y. Jeans, M. N. H. Abdullah, M. S. Mohamed Said, S. S. Shaharir, S. Rajalingham
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease which affects about 0.5% of adults in Malaysia. <h3>Objectives</h3> This study aimed to explore the overall effect of Ramadhan fasting onto RA disease activity and identify drug modification, drug side effects and diet changes occurring in Ramadhan. The study was approved by the Ethics Committee of UKMMC. <h3>Methods</h3> A retrospective case control study was done involving 71 patients who had appointments at the Rheumatology Clinic in UKMMC before Ramadhan and 2 months after Ramadhan, in 2010 and 2011. The fasting cohort (39 patients) and non fasting cohort (32 patients) were compared for RA disease activity (DAS28), intake of medication, side effects and diet before and during Ramadhan. <h3>Results</h3> In the fasting cohort, the mean for DAS28 before Ramadhan was higher than that after Ramadhan but this was not significant (p&gt;0.05). Clinical symptoms of morning stiffness and fatigue were found in fewer patients after Ramadhan but this was not significant (p&gt;0.05). There was a significant reduction in morning stiffness (x<sup>2</sup>=13.380, p=0.001) and in functional class (Z=-2.548, p=0.011) after Ramadhan, in the fasting cohort in 2010. The fasting cohort also showed asignificant reduction in the intake of high calorie food (Z=-2.295, p=0.022) in Ramadhan. There was an improvement in medication compliance among the patients, although this was not significant (p&lt;0.05). <h3>Conclusions</h3> In conclusion, fasting lowers the mean of DAS28 in rheumatoid arthritis patients although this is statistically not significant. During fasting, changes in diet and medication intake do not significantly affect RA disease activity and do not cause significant side effects to fasting patients. <h3>Disclosure of Interest</h3> None Declared
1316 METABOLIC COMORBIDITIES IN A LARGE FRENCH REAL-LIFE COHORT OF PATIENTS WITH CHRONIC HEPATITIS C TREATED WITH PEGINTERFERON ALFA-2A AND RIBAVIRIN
Authors: V. Ratziu, D. Ouzan, A. Tran, J. Denis, P. Mathurin, I. Poizot-Martin, G. Perlemutter, A. Pinta, S. Rouannet, F. Roudot-Thoraval
Journal: Journal of Hepatology (2012)
"Hurry Up and Wait" Characterizes RU486 Status Today
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article “Hurry Up and Wait” Characterizes RU486 Status Today Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 14, 21 July 1993, Pages 1110–1111, https://doi.org/10.1093/jnci/85.14.1110 Published: 21 July 1993
Adenosine Deaminase Isoenzymes and HIV/HTLV-1 Infections
Authors: M. M. YOKOYAMA, I. TSUBOI
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Adenosine Deaminase Isoenzymes and HIV/HTLV-1 Infections Get access MITCHEL M. YOKOYAMA, MITCHEL M. YOKOYAMA Department of Immunology, Kurume University School of Medicine67 Asahimachi Kurume, Fukuoka 830, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar IZUMI TSUBOI IZUMI TSUBOI Department of Immunology, Kurume University School of Medicine67 Asahimachi Kurume, Fukuoka 830, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 9, 6 July 1988, Page 698, https://doi.org/10.1093/jnci/80.9.698 Published: 06 July 1988
2-Chlorodeoxyadenosine to Treat Refractory Histiocytosis X
Authors: Alan Saven, Michael L. Figueroa, Lawrence D. Piro, Joseph D. Rosenblatt
Journal: New England Journal of Medicine (1993)

To the Editor: Treatment of histiocytosis X is palliative at best. It includes corticosteroids, alkylating agents, antimetabolites, vinca alkaloids, and irradiation1. Since 2-chlorodeoxyadenosine, ...