tbuckley/cabot-search huggingface dataset:
CBT may help people who self harm, Cochrane review shows
Authors: Jacqui Wise
Journal: BMJ (2016)

Cognitive behavioural therapy (CBT) may help people who self harm, a Cochrane review of the evidence has concluded. However, the reviewers warned that most of the studies evaluating the intervention were small and that the quality of evidence ranged from moderate to low.

The updated review, published in the Cochrane Library,1 evaluated a range of psychosocial interventions for adults who self harm. The researchers evaluated 55 trials including a total of 17 699 patients who were randomly assigned to receive either psychosocial therapy or the care that they would normally receive. Seventeen of the …
Environmental Factors in Glial Tumor Response to 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea: Effect of Cell Confluence2
Authors: Howard S. Maker, Hasan H. Syed, Gerard M. Lehrer
Journal: JNCI Journal of the National Cancer Institute (1977)

The action of the chemotherapeutic agent 1-(2-chloroethyl)-3-cyclohexyl-1-nltrosourea (CCNU) on C-S rat glioma growing in monolayer culture was studied. C-8 cells were slightly more sensitive to CCNU when exposed during the phase of the cell cycle in which DNA was synthesized. The sensitivity of the cells was Inversely related to the cell densities of the monolayers. Cells in confluent regions of the cultures became labeled with [3H]thymidine at about 70% of the frequency of relatively isolated cells in the same cultures as determined in radioautographs of the monolayers. CCNU (100 μM, 1 hr) caused a moderate decrease of thymidine incorporation into confluent cells while effectively halting all incorporation into nonconfluent cells. The effect of the confluence on sensitivity to the drug was much greater than could be accounted for by the small decrease in growth rate caused by confluence and which also decreases C-8 sensitivity to CCNU. Since confluence varies with cell density, this factor could make a significant contribution to the increasing resistance with increasing density. Studies of the effect of plateau-phase growth on CCNU response, in which growth slowing is caused by high cell density, could also be affected by the confluence factor independently of the effect of proliferation rate on drug response.
Immediate Repair Compared with Surveillance of Small Abdominal Aortic Aneurysms
Authors: Frank A. Lederle, Samuel E. Wilson, Gary R. Johnson, Donovan B. Reinke, Fred N. Littooy, Charles W. Acher, David J. Ballard, Louis M. Messina, Ian L. Gordon, Edmund P. Chute, William C. Krupski, Steven J. Busuttil, Gary W. Barone, Steven Sparks, Linda M. Graham, Joseph H. Rapp, Michel S. Makaroun, Gregory L. Moneta, Robert A. Cambria, Raymond G. Makhoul, Darwin Eton, Howard J. Ansel, Julie A. Freischlag, Dennis Bandyk
Journal: New England Journal of Medicine (2002)

Whether elective surgical repair of small abdominal aortic aneurysms improves survival remains controversial.
Effect of a Diet With High Levels of Protein and Fat on Colon Carcinogenesis in F344 Rats Treated With 1,2-Dimethylhydrazine2
Authors: Bandaru S. Reddy, T. Narisawa, J. H. Weisburger
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article Effect of a Diet With High Levels of Protein and Fat on Colon Carcinogenesis in F344 Rats Treated With 1,2-Dimethylhydrazine Get access Bandaru S. Reddy, Bandaru S. Reddy Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Narisawa, T. Narisawa Search for other works by this author on: Oxford Academic PubMed Google Scholar J. H. Weisburger J. H. Weisburger Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 57, Issue 3, September 1976, Pages 567–569, https://doi.org/10.1093/jnci/57.3.567 Published: 01 September 1976 Article history Received: 18 November 1975 Accepted: 01 March 1976 Published: 01 September 1976
Case 28-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Alfred Kranes, Joel Umlas, Edward P. Richardson
Journal: New England Journal of Medicine (1970)

Presentation of CaseA 61-year-old man entered the hospital because of constipation.Nineteen years previously a tendon in the right thumb had been severed. Four years later profound weakness of the right hand developed abruptly and progressed in severity, without relief from multiple tendon operations. He had awakened from one of the tendon operations blind in the right eye. At about that time crops of bullae began to appear on the palmar surfaces of the hands, about the interphalangeal joints and on the wrists and elbows; the lesions characteristically burst and required months to heal, with accompanying stiffness of the . . .
Synergistic Effect of Magnetic Nanopartical Fe304, Au and Daunomycin on K562/A02.
Authors: Bao-An Chen, Yong-Yuan Dai, Xue Mei Wang, Ren-Yun Zhang, Feng Gao, Jian Chen, Chong Gao, Yun-Yu Sun, Jun Wang, Gang Zhao, Jia-Hua Ding, Ning-Na Chen, Xiao-Ping Pei
Journal: Blood (2007)
Authors’ reply to Sarri and colleagues: Table 1
Authors: Martha Hickey, Emily Banks
Journal: BMJ (2016)

The current combined evidence from conventional and from network meta-analyses of randomised controlled trial (RCT) data is that menopausal hormone therapy (MHT) is effective for the relief of vasomotor symptoms.1 2 We noted this in our editorial and agree with the National Institute for Health and Care Excellence (NICE) guidelines on this matter,3 so we are unsure why Sarri and colleagues considered this a point of contention.4

We also agree that women differ in their priorities and information needs, and that it is important to provide summary evidence on the risks and benefits of MHT according to each outcome separately. However, an overall assessment of whether MHT is likely to be harmful or beneficial for health in terms of serious potentially life threatening conditions is also important information for many women and their healthcare professionals. We remain concerned that the NICE guidelines do not present women and healthcare professionals with appropriate and useful summary estimates on the risks of MHT for serious disease. In particular:

1.  It is inappropriate to restrict RCT data to those from women aged 50-59 years at trial entry. We did not misunderstand Sarri and colleagues on this point. It is a statistical principle that, where effects in study subgroups such as age do …
T- Cell Depleted Peripheral Blood Stem Cell (TCD-PBSC) Transplants Secure Consistent Engraftment with Low Risk of Acute or Chronic Gvhd and Favorable Disease Free Survival (DFS) and Overall Survival (OS) for Pediatric Patients (&lt;21 years) with AML in CR1 or CR2 or MDS Including tMDS/AML
Authors: Nancy A. Kernan, Farid Boulad, Susan Prockop, Suzanne Wolden, Andromachi Scaradavou, Rachel Kobos, Rachel Lehrman, Elizabeth Klein, Kevin J. Curran, Aisha N Hasan, Sharon Bleau, Julianne Ruggiero, Nicole Zakak, Anne Casson, Joanne Torok-Castanza, Richard J O'Reilly
Journal: Blood (2015)
Immunochemotherapy with Fludarabine (F), Cyclophosphamide (C), and Rituximab (R) (FCR) Versus Fludarabine and Cyclophosphamide (FC) Improves Response Rates and Progression-Free Survival (PFS) of Previously Untreated Patients (pts) with Advanced Chronic Lymphocytic Leukemia (CLL)
Authors: Michael Hallek, Guenter Fingerle-Rowson, Anna- Maria Fink, Raymonde Busch, Jiri Mayer, Manfred Hensel, Georg Hopfinger, Georg Hess, Ulrich von Gruenhagen, Manuela A. Bergmann, John Catalano, Pier Luigi Zinzani, Federico Caligaris Cappio, John Francis Seymour, Alain Berrebi, Ulrich Jaeger, Bruno Cazin, Marek Trneny, Anne Westermann, Clemens-Martin Wendtner, Barbara F. Eichhorst, Peter Staib, Sebastian Boettcher, Matthias Ritgen, Stephan Stilgenbauer, Myriam Mendila, Michael Kneba, Hartmut Döhner, Kirsten Fischer
Journal: Blood (2008)
Hydrogel as a bioactive material to regulate stem cell fate
Authors: Yung-Hao Tsou, Joe Khoneisser, Ping-Chun Huang, Xiaoyang Xu
Journal: Bioactive Materials (2016)

The encapsulation of stem cells in a hydrogel substrate provides a promising future in biomedical applications. However, communications between hydrogels and stem cells is complicated; various factors such as porosity, different polymer types, stiffness, compatibility and degradation will lead to stem cell survival or death. Hydrogels mimic the three-dimensional extracellular matrix to provide a friendly environment for stem cells. On the other hand, stem cells can sense the surroundings to make the next progression, stretching out, proliferating or just to remain. As such, understanding the correlation between stem cells and hydrogels is crucial. In this Review, we first discuss the varying types of the hydrogels and stem cells, which are most commonly used in the biomedical fields and further investigate how hydrogels interact with stem cells from the perspective of their biomedical application, while providing insights into the design and development of hydrogels for drug delivery, tissue engineering and regenerative medicine purpose. In addition, we compare the results such as stiffness, degradation time and pore size as well as peptide types of hydrogels from respected journals. We also discussed most recently magnificent materials and their effects to regulate stem cell fate.
Abstract MP46: Usual Walking Pace is More Strongly Associated with Lower Risk of Heart Failure Than Total Physical Activity in the Women’s Health Study
Authors: Luc Djousse, Claudia Chae, Julie E Buring, I-Min Lee
Journal: Circulation (2016)

Background: While previous studies have reported lower risk of coronary heart disease with physical activity, limited data exist on the relation of physical activity with heart failure risk in a community setting. Objective: To test the primary hypothesis that physical activity is inversely associated with HF risk in a cohort of apparently healthy women and a secondary hypothesis that walking time and usual walking pace are associated with lower risk of HF. Methods: Prospective cohort study of 39,635 participants from the Women’s Health Study. Information on leisure-time physical activity, including walking time and usual pace, was self-reported at baseline and HF was ascertained through annual follow-up questionnaires with validation through review of medical records. We used Cox regression to estimate multivariable adjusted hazard ratios of HF. Results: During a mean follow-up of 17.2 years, 635 cases of HF occurred. The mean age at baseline was 54.6 ± 7.0 years. Median physical activity was 8.4 MET-h/week (IQR: 2.7-20.2); about 18% of women did not walk regularly while 32% reported walking pace of 3+ miles per hour. In a multivariable adjusted model, hazard ratios (95% CI) for HF were 1.0 (ref), 0.73 (0.57-0.95), 0.86 (0.69-1.07), 0.70 (0.54-0.92), and 0.93 (0.66-1.05) for physical activity of &lt;3.75, 3.75-7.4, 7.5-14.9, 15-22.4, and 22.5+ MET-h/week, respectively (p trend 0.043). However, the association was attenuated upon additional adjustment for usual walking pace (corresponding HR: 1.0 (ref), 0.77 (0.60-1.01), 0.93 (0.73-1.18), 0.77 (0.58-1.02), and 0.94 (0.73-1.22), p trend 0.47). Walking time showed a J-shaped relation with risk, that also was attenuated after adjustment for pace and MET-h/wk (HR: 1.0 (ref), 1.19 (0.94-1.50), 1.06 (0.80-1.39), 0.69 (0.50-0.97), 0.84 (0.63-1.12), and 0.87 (0.63-1.20) for walking time of 0-19 min/wk, 20-59 min/wk, 1h/wk, 1.5h/wk, 2-3h/wk, and 4+h/wk, respectively). In contrast, usual walking pace was inversely associated with HF risk even after adjustment for total physical activity and walking time with multivariable adjusted HR of 1.0 (ref), 0.97 (0.75-1.24), 0.88 (0.70-1.10), and 0.74 (0.55-0.98) for walking pace of 0, &lt;2, 2-2.9, and 3+ miles per hour, respectively, p trend 0.038). Conclusions: Our data show inverse associations of total leisure-time physical activity with HF risk that was attenuated after adjustment for usual walking pace. In contrast, usual walking pace was inversely and robustly associated with HF risk while walking time showed a J-shaped relation.
Catheter Ablation for Atrial Fibrillation in Congestive Heart Failure
Authors: Li-Fern Hsu, Pierre Jaïs, Prashanthan Sanders, Stéphane Garrigue, Mélèze Hocini, Fréderic Sacher, Yoshihide Takahashi, Martin Rotter, Jean-Luc Pasquié, Christophe Scavée, Pierre Bordachar, Jacques Clémenty, Michel Haïssaguerre
Journal: New England Journal of Medicine (2004)

Congestive heart failure and atrial fibrillation often coexist, and each adversely affects the other with respect to management and prognosis. We prospectively evaluated the effect of catheter ablation for atrial fibrillation on left ventricular function in patients with heart failure.
Topical application of a vitamin D3 analogue and corticosteroid to psoriasis plaques decreases skin infiltration of TH17 cells and their ex vivo expansion
Authors: Toshiharu Fujiyama, Taisuke Ito, Takatsune Umayahara, Shigeki Ikeya, Kazuki Tatsuno, Atsuko Funakoshi, Hideo Hashizume, Yoshiki Tokura
Journal: Journal of Allergy and Clinical Immunology (2016)
Therapeutically Induced Changes in HER2, HER3, and EGFR Protein Expression for Treatment Guidance
Authors: Shankar Sellappan, Adele Blackler, Wei-Li Liao, Emily O'Day, Peng Xu, Sheeno Thyparambil, Fabiola Cecchi, Todd Hembrough, Daniel V T Catenacci
Journal: Journal of the National Comprehensive Cancer Network (2016)

Protein-targeted therapies are expected to selectively kill tumor cells that express the targeted protein biomarker. Although a tumor mass may initially respond to targeted therapies based on expression of the targeted protein, all cells within a tumor may not express the targeted protein above a critical threshold level; therefore, those cells that do not express, or that downregulate expression of, the targeted protein may not be responsive to therapy. The ability to monitor the dynamic expression of these protein biomarkers throughout the course of therapy may allow for treatment to be personalized in real-time in response to the evolving nature of the tumor. This report demonstrates, by monitoring a single patient through multiple therapies, how targeted mass spectrometry is an effective, quantitative method that provides real-time analysis of multiple therapeutically associated targeted proteins that can be used to personalize a patient's treatment strategy throughout the course of care.
Abstract 14: The Cytoskeletal Architecture of Myocytes Derived from Human Cardiac Progenitor Cells
Authors: Francesco Pasqualini, Moises Di Sante, João D Pereira, Piero Anversa, Marcello Rota, Annarosa Leri
Journal: Circulation Research (2014)

The stem cell antigen c-kit characterizes a heterogeneous pool of human cardiac progenitor cells (hCPCs) that exhibit a remarkable degree of regenerative potential and are currently employed in clinical trials. While this hCPC pool contains distinct subpopulations of c-kit+ cells that preferentially differentiate into muscular or vascular cardiac cells, we hypothesize that hCPCs may be coerced to specify only along the cardiomyogenic lineage by manipulating the Wnt/β-catenin pathway. We report that pharmacological inhibition of the non-canonical Wnt pathway facilitated the commitment of more than &gt;95% c-kit+ hCPCs to the cardiomyocyte lineage after 4 days in-vitro: this constitutes a substantially more homogeneous population than previously reported with dexamethasone treatment. The hCPC-derived myocytes stained positive for Nkx2.5, a transcription factor that orchestrates cardiomyogenic differentiation, and for the contractile protein sarcomeric α-actin. To test if we could push the cells towards a more mature phenotype, we mimicked the cyclic modulation of the Wnt pathway observed during development. While activation of Wnt signaling resulted in widespread cell death and reduction in cell size, subsequent Wnt inhibition prompted the spared cells to proliferate. With this protocol, hCPC-derived myocytes increased in size and displayed more mature cytoskeletal architectures. In contrast with dexamethasone treated cells, where the localization of α-sarcomeric actinin is mostly diffuse in the cytoplasm, here we observed both Z-bodies and Z-disks like structures. The latter exhibited a periodicity of ~1.6 um and were clustered in larger, more aligned actin bundles. This finding suggests that the tension developed along these cytoskeletal components may play a role in the recruitment of sarcomeric proteins. In conclusion, Wnt signaling inhibition in hCPCs may be sufficient to obtain a homogeneous population of cells with features of myocytes, characterized by improved cytoskeletal organization than dexamethasone treated cells and similar to that observed in myocytes derived from human induced pluripotent stem cells.
Hydrocortisone as an Intervention for Dexamethasone-Induced Adverse Effects in Pediatric Patients With Acute Lymphoblastic Leukemia: Results of a Double-Blind, Randomized Controlled Trial
Authors: Lidewij T. Warris, Marry M. van den Heuvel-Eibrink, Femke K. Aarsen, Saskia M.F. Pluijm, Marc B. Bierings, Cor van den Bos, Christian M. Zwaan, Helene H. Thygesen, Wim J.E. Tissing, Margreet A. Veening, Rob Pieters, Erica L.T. van den Akker
Journal: Journal of Clinical Oncology (2016)

Purpose Dexamethasone is a key component in the treatment of pediatric acute lymphoblastic leukemia (ALL), but can induce serious adverse effects. Recent studies have led to the hypothesis that neuropsychological adverse effects may be a result of cortisol depletion of the cerebral mineralocorticoid receptors. We examined whether including a physiologic dose of hydrocortisone in dexamethasone treatment can reduce neuropsychologic and metabolic adverse effects in children with ALL. Patients and Methods We performed a multicenter, double-blind, randomized controlled trial with a crossover design. Of 116 potentially eligible patients (age 3 to 16 years), 50 were enrolled and were treated with two consecutive courses of dexamethasone in accordance with Dutch Childhood Oncology Group ALL protocols. Patients were randomly assigned to receive either hydrocortisone or placebo in a circadian rhythm (10 mg/m 2 /d) during both dexamethasone courses. Primary outcome measure was parent-reported Strength and Difficulties Questionnaire in Dutch, which assesses psychosocial problems. Other end points included questionnaires, neuropsychological tests, and metabolic parameters. Results Of 48 patients who completed both courses, hydrocortisone had no significant effect on outcome; however, a more detailed analysis revealed that in 16 patients who developed clinically relevant psychosocial adverse effects, addition of hydrocortisone substantially reduced their Strength and Difficulties Questionnaire in Dutch scores in the following domains: total difficulties, emotional symptoms, conduct problems, and impact of difficulties. Moreover, in nine patients who developed clinically relevant, sleep-related difficulties, addition of hydrocortisone reduced total sleeping problems and disorders of initiating and maintaining sleep. In contrast, hydrocortisone had no effect on metabolic parameters. Conclusion Our results suggest that adding a physiologic dose of hydrocortisone to dexamethasone treatment can reduce the occurrence of serious neuropsychological adverse effects and sleep-related difficulties in pediatric patients with ALL.
Diabetic Ketoacidosis Following Bariatric Surgery in Patients With Type 2 Diabetes
Authors: Amin Andalib, Aly Elbahrawy, Saeed Alshlwi, Ahmed Alkhamis, Wen Hu, Sebastian Demyttenaere, Rajesh Aggarwal, Olivier Court
Journal: Diabetes Care (2016)

Diabetic ketoacidosis (DKA) is a life-threatening complication mainly linked to type 1 diabetes. Clinical features of DKA after bariatric surgery are mostly unknown and likely underreported, especially in those with type 2 diabetes. The objective of this study is to emphasize occurrence and clinical presentation of DKA in patients with type 2 diabetes after bariatric surgery. We also aim to describe diagnostic challenges related to new medications such as sodium–glucose cotransporter 2 inhibitors (SGLT-2i) that can cause euglycemic DKA (1,2).

We report four cases of DKA in three patients with type 2 diabetes after bariatric surgery at a single institution from January 2010 to December 2015. All cases presented within 30 days following surgery, were classified as moderate to severe based on criteria from the American Diabetes Association (3,4 …
Abstract 1035: Analysis of the Mechanisms Responsible for the Genesis of the Complex Fractionated Atrial Electrogram During Atrial Fibrillation Using 3D Non-Contact Mapping System
Authors: Hiroshige Yamabe, Kenji Morihisa, Yasuaki Tanaka, Takashi Uemura, Koji Enomoto, Hisao Ogawa
Journal: Circulation (2008)

Complex fractionated atrial electrogram (CFAE) region has been implicated as the substrate of atrial fibrillation (AF). However, how its electrogram morphology is generated has not been precisely evaluated. The purpose of this study was to investigate the mechanisms responsible for the genesis of the CFAE during AF. In 16 patients with paroxysmal AF, endocardial mapping of the left atrium was performed during AF using 3D non-contact mapping system (EnSite 3000). After localization of CFAE region, we examined the activation sequence of the wave during AF. Then, we compared the conduction velocity of the wave, frequency of wave break-up and wave fusion, and frequency of pivoting activation observed during AF between CFAE and non-CFAE regions. The CFAE was located in the roof (100%), anterior (50%), posterior (56%), pulmonary vein (PV) (81%), appendage (81%) and septum (81%), respectively. The area of CFAE was 13.4±5.0 cm2. During AF, 1 to 4 meandering reentrant waves with a maximum number of 2.3±0.7 were observed. The conduction velocity of the wave at the CFAE region was significantly slower than that at the non-CFAE region (0.65±0.38 vs. 2.31±0.89 m/second, p&lt;0.0001). In addition, there were frequent episodes of pivoting conduction, wave break-up and wave fusion in the CFAE region, which were resulted in the generation of the multiple deflections of the local electrogram in the CFAE region. Thus, the frequency of the pivoting conduction (5.0±2.1 vs. 0.3±0.8 times/second, p&lt;0.0001), wave break-up (5.5±3.8 vs. 0±0 times/second, p&lt;0.0001) and wave fusion (6.5±5.8 vs. 3.6±3.1 times/second, p&lt;0.05) at the CFAE region were significantly higher than those at the non-CFAE region. At the CFAE region, the wave break-up produced a new wave and the fused waves were organized into a new wave, then propagated to the next adjacent excitable region, resulted in the perpetuation of reentrant wave propagation. The multiple deflections of the electrogram at the CFAE region was generated by the slow conduction, frequent episodes of pivoting conduction, wave break-up and wave fusion. These features imply that CFAE region provide an important substrate for the perpetuation of reentrant wave propagation and maintenance of AF.