tbuckley/cabot-search huggingface dataset:
Cognitive and affective responses to lithium in patients with organic brain syndrome
Authors: K H Williams, G Goldstein
Journal: American Journal of Psychiatry (1979)

The authors describe a series of patients with organic brain syndrome who showed a dramatic clinical response to lithium carbonate therapy. None of the patients had been diagnosed as manic-depressive. Most had extensive psychiatric treatment experiences and had been given both affective and cognitive diagnoses. Six of the eight patients also qualified for the diagnosis of alcoholism. They had been treated with a wide variety of psychotherapeutic medications. Lithium was found to be rapidly and dramatically effective in patients with static lesions of the central nervous system who showed a combination of dementia and agitated depression.
Suppression of the Mitogenic Response to Phytohemagglutinin in Malignant Neoplasia: Correlation With Clinical Stage and Therapy 2
Authors: Tamar Mekori, Shulamith Sher, Eliezer Robinson
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Suppression of the Mitogenic Response to Phytohemagglutinin in Malignant Neoplasia: Correlation With Clinical Stage and Therapy Get access Tamar Mekori, Tamar Mekori Search for other works by this author on: Oxford Academic PubMed Google Scholar Shulamith Sher, Shulamith Sher Search for other works by this author on: Oxford Academic PubMed Google Scholar Eliezer Robinson Eliezer Robinson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 1, January 1974, Pages 9–12, https://doi.org/10.1093/jnci/52.1.9 Published: 01 January 1974 Article history Received: 02 February 1973 Revision received: 10 August 1973 Accepted: 30 August 1973 Published: 01 January 1974
The relationship between affective disorder and eating disorders: a review of the literature
Authors: W J Swift, D Andrews, N E Barklage
Journal: American Journal of Psychiatry (1986)

The authors review the relationship between affective disorder and anorexia nervosa and bulimia across five lines of inquiry: clinical reports, psychometrics, family history, drug studies, and follow-up investigations. They conclude that affective disorder and eating disorders are related but that the nature of the relationship is unclear. After discussing possible mediating patterns, the authors propose an interactive, multidetermined understanding as the most appropriate model. They recommend that future research in this area attempt to identify subpopulations of patients with affective disorder and eating disorders by means of a longitudinal, multilevel strategy with serial determinations.
P2-127: Effects of insulin like growth factor-1 on repair mechanism of DNA damage induced by cis-Diammineplatinum dichloride in NSCLC
Authors: Jeong Hee Jeon, Yoon Soo Chang, Se Kyu Kim, Hyung Jung Kim, Joon Chang, Chul Min Ahn, Sung Kyu Kim
Journal: Journal of Thoracic Oncology (2007)
Diagnosing Colitis: a Prospective Study on Essential Parameters for Reaching a Diagnosis
Authors: C. Dejaco, C. Oesterreicher, S. Angelberger, A. Püspök, P. Birner, R. Poetzi, A. Gangl, G. Oberhuber
Journal: Endoscopy (2003)

Background and Study Aims: It is generally believed that making a correct histological diagnosis of colitis at colonoscopy requires segmental mucosal biopsies, information on the endoscopic features, and clinical data. This prospective study was carried out to determine the essential parameters required for an accurate diagnosis of colitis. Patients and Methods: Two hundred consecutive patients with suspected or established colitis who underwent colonoscopy were prospectively examined. A double biopsy was taken at a macroscopic site of typical inflammation, or, if no abnormalities could be found, from normal mucosa. In addition, segmental biopsies were obtained. Endoscopic features and the patient's clinical history and symptoms were recorded. Histology was analyzed by providing the pathologist with the double-biopsy sample, segmental biopsies, and endoscopic and clinical information in a segmental fashion. Changes in the diagnoses were noted after each step of the analysis. Results: Colitis was diagnosed in 152 patients (76 %). Double-biopsy examination provided the correct final diagnosis in 66 % of cases. After assessment of the segmental biopsies, the diagnosis had to be changed in 26 % of cases. Information on the endoscopic features altered the diagnosis in 2.5 %. Finally, the diagnosis was changed in an additional 5.5 % of cases after clinical data (the patient's history and symptoms) had been provided. Conclusions: Segmental biopsy specimens are essential for the differential diagnosis of intestinal inflammation. Information on the endoscopic features and clinical data are useful in differentiating some forms of colitis.
SP0030 Is Imaging Sufficiently Standardised to Implement in Clinical Practice?
Authors: M.A. D'Agostino
Journal: Annals of the Rheumatic Diseases (2015)

Imaging and biochemistry are amongst the most rapidly evolving fields within medicine. In the last 30 years, clinical practice has been transformed by the rapid expansion of sophisticated new technologies in those fields offering a large range of instruments for better identifying, monitoring and sometimes predicting pathological processes. As compared to therapeutic interventions, one of the main problems is the lack of standard procedures for validating new tools before their widespread application. This is mostly related to the complexity of the validation process, which requires a multidisciplinary approach involving technology assessment, efficacy (including effectiveness and efficiency) and outcomes, generating sometimes biases in the evaluation of the capability of the tool. An additional problem is related to the typology of the new technology under study. In the imaging field is quite easy to demonstrate the technical improvement in the detection of the pathological process: magnetic resonance imaging (MRI) visualize better than computed tomography (CT) the brain lesions, as well as MRI or ultrasound visualize joint synovitis in rheumatoid arthritis (RA) patients better than CT or conventional radiography (CR). Therefore nearly all publications in imaging are focused on technical and diagnostic performances of the new instruments and few studies are performed on the real impact of the use of those techniques for the therapeutic and clinical management of patients. Moreover when such studies are performed, they are far to show a real improvement in the management of patients in term of diagnostic cost, treatment or quality of life. The objective of the presentation is to discuss the indications and possible biais in the application of imaging in rheumatic diseases. <h3>Disclosure of Interest</h3> None declared
E7208: A randomized phase II trial of irinotecan and cetuximab (IC) versus IC plus ramucirumab (ICR) in second line therapy of KRAS wild type colorectal cancer (CRC).
Authors: Howard S. Hochster, Paul J. Catalano, Edith P. Mitchell, Deirdre Jill Cohen, Peter J. O'Dwyer, Al Bowen Benson
Journal: Journal of Clinical Oncology (2015)

TPS793 Background: Anti-angiogenic therapy for CRC has been accepted as standard therapy with approval of bevacizumab (bev) in both first-line and second-line settings. At the time this study was started, the benefit of continuing an anti-angiogenic in second line therapy was unproven. Ramucirumab (RAM, IMC 1121b) is a humanized antibody directed against the VEGF-R2 receptor, which may prove to have different activity compared to anti-VEGF antibody (bev). Additionally, while combining the anti-EGFR antibody, cetuximab (CMAB), with bev in first-line unselected patients was not effective, it is unknown whether the same may be true with RAM plus CMAB in a second-line setting for KRAS-selected patients. Methods: The study was designed as a randomized phase II trial with 147 patients assigned to IC = irinotecan (I) 180 mg/m 2 IV plus CMAB 500 mg/m 2 IV q2w versus ICR = IC plus RAM 8 mg/kg IV q2w. Eligibility included prior treatment on one prior oxaliplatin and bev-containing regimen and progression within 42 days of last bev, PS 0-1, KRAS codon 12,13 wild-type and standard other chemo and bev criteria. Doses were modified for neutropenia, diarrhea, mucositis, rash and grade 3 other toxicities. The study was activated 10/8/10. The first 35 patients were enrolled and accrual was held 6/24/12 for toxicity analysis per protocol. More grade 3 events of mucositis, diarrhea, neutropenia and perforation events (including peri-rectal abscesses) were seen in the ICR arm. The study has been modified reflect the actual doses received, and now uses modified ICR (mICR) = I 150 mg/m 2 , CMAB 400 mg/m 2 and RAM 6 mg/kg IV q2w. The study was re-activataed in May 2014. An additional 100 pts will be accrued to the revised study, giving 85% power to detect improved median PFS from 4.5 to 7.65 months. New eligibility criteria include any progression from first-line chemo (on or off), normal albumin, no bowel perforation or obstruction in last 6 months. This study is now open to accrual in ECOG-ACRIN and in SWOG with endorsement, and via CTSU. Clinical trial information: NCT01079780.
Novel Hydrogenosomes in the Microaerophilic Jakobid<i>Stygiella incarcerata</i>
Authors: Michelle M. Leger, Laura Eme, Laura A. Hug, Andrew J. Roger
Journal: Molecular Biology and Evolution (2016)

Mitochondrion-related organelles (MROs) have arisen independently in a wide range of anaerobic protist lineages. Only a few of these organelles and their functions have been investigated in detail, and most of what is known about MROs comes from studies of parasitic organisms such as the parabasalid Trichomonas vaginalis Here, we describe the MRO of a free-living anaerobic jakobid excavate, Stygiella incarcerata We report an RNAseq-based reconstruction of S. incarcerata's MRO proteome, with an associated biochemical map of the pathways predicted to be present in this organelle. The pyruvate metabolism and oxidative stress response pathways are strikingly similar to those found in the MROs of other anaerobic protists, such as Pygsuia and Trichomonas This elegant example of convergent evolution is suggestive of an anaerobic biochemical 'module' of prokaryotic origins that has been laterally transferred among eukaryotes, enabling them to adapt rapidly to anaerobiosis. We also identified genes corresponding to a variety of mitochondrial processes not found in Trichomonas, including intermembrane space components of the mitochondrial protein import apparatus, and enzymes involved in amino acid metabolism and cardiolipin biosynthesis. In this respect, the MROs of S. incarcerata more closely resemble those of the much more distantly related free-living organisms Pygsuia biforma and Cantina marsupialis, likely reflecting these organisms' shared lifestyle as free-living anaerobes.
Leonard Wood
Authors: Charles H. Bradford
Journal: New England Journal of Medicine (1952)

IN 1884, Leonard Wood was launched on a career of greatness by being fired. He was an intern at the Boston City Hospital at the time. Regulations forbade house doctors from performing even minor operations without formal permission, but Wood disregarded the formality in a case of a simple skin graft. The superintendent ordered his dismissal, and although the visiting surgeons submitted a written protest, with high commendation of Wood, his punishment was approved by the trustees. From his office, the superintendent watched Wood walk out of the institution, and remarked, "There goes a young man who will never come . . .
Relation of Cortisone-Induced Lymphopenia to Transplanted Sarcoma in Hamsters&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: Edward D. Crabb, Ph. D., Margaret A. Kelsall, Ph. D.
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Relation of Cortisone-Induced Lymphopenia to Transplanted Sarcoma in Hamsters Get access Edward D. Crabb, Ph. D., Edward D. Crabb, Ph. D. Department of Biology, University of Colorado, Boulder, Colo. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret A. Kelsall, Ph. D. Margaret A. Kelsall, Ph. D. Department of Biology, University of Colorado, Boulder, Colo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 1, August 1951, Pages 91–105, https://doi.org/10.1093/jnci/12.1.91 Published: 01 August 1951 Article history Received: 03 April 1951 Published: 01 August 1951
Multitasking basal cells: combining stem cell and innate immune duties
Authors: Renat Shaykhiev
Journal: European Respiratory Journal (2015)

The airway epithelium, which covers the luminal surface of the tracheobronchial tree, is a primary barrier that protects the lung from pathogens, irritants, toxic substances and other stressors present in the ∼10 000 L of air flowing through the airways every day. This barrier function is normally mediated by differentiated ciliated and secretory cells strategically positioned in the apical layer to interact with the luminal content. Via production of mucus and antimicrobial substances, and continuous beating of the cilia to remove mucus-trapped bacteria and other airborne particles from the airways, these cells protect the lung from respiratory damage and infection [1]. In addition, tight junctions (multiprotein complexes between the apical membrane domains of adjacent differentiated cells) control diffusion of the luminal content across the epithelium, preventing activation of numerous receptors and inflammatory cells enriched in the basolateral compartment or beneath the epithelium [2, 3]. Human airway basal stem cells contribute to host–microbe interactions and innate immunity in the lung <http://ow.ly/Q2UAF>
Complete Spontaneous Submucosal Dissection of the Sigmoid Colon
Authors: C de la Serna-Higuera, M I Martín-Arribas, S J Rodríguez-Gómez, A Pérez Villoria, C González del Rey
Journal: Endoscopy (2004)

Figure 1 A 73-year-old woman presented with cramps and scant hematochezia. She was otherwise healthy. There was no history of prior illness, drug ingestion, trauma, or foreign-body introduction. The physical examination only showed a large, membranous structure protruding through the anal canal. Laboratory values were within normal limits. Flexible sigmoidoscopy revealed markedly erythematous, swollen sigmoid mucosal sloughing, involving almost one-third of the lumen at this level.
3. Electrospun polymer fibers as a versatile delivery platform for small molecules and macromolecules
Authors: Nicholas A. Peppas, Ruth Duncan, Gary E. Wnek, Allan S. Hoffman, Guang Hui Gao, Sung Wan Kim, Doo Sung Lee, Michael Hadjiargyrou, Elka Touitou, Denize Ainbinder, Russell Mumper, Alain Rolland, Takuro Niidome, Vinod Labhasetwar, Shi Liu, Guangyuan Zhou, Yubin Huang, Zhigang Xie, Xiabin Jing, Noemi Csaba
Journal: Journal of Controlled Release (2014)
Cross-Stratification and Differential Risk by Breast Cancer Index and Recurrence Score in Women with Hormone Receptor–Positive Lymph Node–Negative Early-Stage Breast Cancer
Authors: Ivana Sestak, Yi Zhang, Brock E. Schroeder, Catherine A. Schnabel, Mitch Dowsett, Jack Cuzick, Dennis Sgroi
Journal: Clinical Cancer Research (2016)

Abstract Purpose: Previous results from the TransATAC study demonstrated that both the Breast Cancer Index (BCI) and the OncotypeDX Recurrence Score (RS) added significant prognostic information to clinicopathologic factors over a 10-year period. Here, we examined cross-stratification between BCI and RS to directly compare their prognostic accuracy at the individual patient level. Experimental Design: A total of 665 patients with hormone receptor–positive (HR+) and lymph node–negative disease were included in this retrospective analysis. BCI and RS risk groups were determined using predefined clinical cut-off points. Kaplan–Meier estimates of 10-year risk of distant recurrence (DR) and log-rank tests were used to examine cross-stratification between BCI and RS. Results: As previously reported, both RS and BCI were significantly prognostic in years 0 to 10. BCI provided significant additional prognostic information to the Clinical Treatment Score (CTS) plus RS (ΔLR-χ2 = 11.09; P &amp;lt; 0.001), whereas no additional prognostic information was provided by RS to CTS plus BCI (ΔLR-χ2 = 2.22; P = 0.1). Restratification by BCI of the low and intermediate RS risk groups led to subgroups with significantly different DR rates (P &amp;lt; 0.001 and P = 0.003, respectively). In contrast, restratified subgroups created by RS of BCI risk groups did not differ significantly. Conclusions: In this retrospective analysis, BCI demonstrated increased prognostic accuracy versus RS. Notably, BCI identified subsets of RS low and RS intermediate risk patients with significant and clinically relevant rates of DR. These results indicate that additional subsets of women with HR+, lymph node–negative breast cancer identified by BCI may be suitable candidates for adjuvant chemotherapy or extended endocrine therapy. Clin Cancer Res; 22(20); 5043–8. ©2016 AACR. See related commentary by Brufsky and Davidson, p. 4963
Electrohydraulic lithotripsy under peroral direct cholangioscopy using short-type single-balloon enteroscope for large common bile duct stone in patients with Roux-en-Y gastrectomy
Authors: Hiroshi Yamauchi, Mitsuhiro Kida, Shiro Miyazawa, Kosuke Okuwaki, Hiroshi Imaizumi, Wasaburo Koizumi
Journal: Endoscopy (2015)

Balloon enteroscopy-assisted endoscopic retrograde cholangiopancreatography (BEA-ERCP) has improved the outcomes of ERCP in patients with reconstructed gastrointestinal anatomy [1] [2]. However, BEA-ERCP requires high technical expertise, and large stones in the common bile duct (CBD) are difficult to treat. Binmoeller at al. reported that electrohydraulic lithotripsy (EHL) is useful for the treatment of CBD stones that could not be engaged in the basket in patients with normal gastrointestinal anatomy [3]. EHL with an ultra-slim endoscope during peroral direct cholangioscopy (PDCS) [4], and EHL with a single-balloon enteroscope under PDCS [5] have been reported in patients with hepaticojejunostomy. This report describes a 78-year-old man with gastric cancer who underwent Roux-en-Y total gastrectomy. EHL was performed with a short-type single-balloon enteroscope (prototype, SIF-Y0004V01; Olympus Medical Systems, Tokyo, Japan) under PDCS.
Effect of Growth of Mouse Sarcoma 37 on Resistance of Mice to Semilethal Doses of Certain Trivalent Arsenic Compounds
Authors: L V BECK, R J GILLESPIE
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Effect of Growth of Mouse Sarcoma 37 on Resistance of Mice to Semilethal Doses of Certain Trivalent Arsenic Compounds Get access Lyle V. Beck, Lyle V. Beck Laboratory of Chemical Pharmacology, National Cancer Institute,5Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruth Joyce Gillespie Ruth Joyce Gillespie Laboratory of Chemical Pharmacology, National Cancer Institute,5Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 6, June 1954, Pages 1223–1232, https://doi.org/10.1093/jnci/14.6.1223 Published: 01 June 1954 Article history Received: 27 February 1953 Published: 01 June 1954
Fracture of the Month 23 Number
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1962)

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Individual differences in serum sodium levels in schizophrenic men with self-induced water intoxication
Authors: A B Koczapski, R C Millson
Journal: American Journal of Psychiatry (1989)

Eight men with chronic schizophrenia and self-induced water intoxication showed marked individual differences in their serum sodium levels. The severity of the intoxication symptoms reflected the amount and speed of change in sodium levels rather than the absolute sodium values.
An outbreak of Salmonella enteritidis infection associated with iced cake
Authors: P D'Argenio, A Romano, F Autorino
Journal: Eurosurveillance (1999)

Several people developed severe symptoms of gastroenteritis after attending a first holy communion banquet in Benevento, a town of 60 000 inhabitants in southern Italy. About 60 people had attended the banquet, held on 14 June 1998, between 1400 and 1800
Eye movement impairment and schizotypal psychopathology
Authors: L J Siever, L Friedman, J Moskowitz, V Mitropoulou, R Keefe, S L Roitman, D Merhige, R Trestman, J Silverman, R Mohs
Journal: American Journal of Psychiatry (1994)

Eye movement dysfunction in relation to a smooth pursuit task has been documented in schizophrenic patients and in patients with the related personality disorder, schizotypal personality disorder. To investigate which quantitative measures are associated with the eye movement dysfunction and whether the dysfunction is more related to the psychotic-like or the deficit-like symptoms of schizotypal personality disorder, ratings of eye movements in several groups of subjects were compared.The study groups consisted of 26 patients with schizotypal personality disorder, 42 patients with other personality disorders (22 who also had two or more schizotypal personality traits and 20 who had fewer than two), and 37 normal comparison subjects. Smooth pursuit eye tracking of sinusoidal and constant velocity targets was recorded by an infrared eye tracking system. Two raters evaluated pursuit gain and large and small saccades in the direction of the target and in the direction opposite to that of the target (quantitative ratings) and constant velocity (qualitative rating).Patients with schizotypal personality disorder and patients with other personality disorders and two or more schizotypal traits, but not those with fewer than two schizotypal traits, had significantly poorer qualitative ratings of tracking than the normal comparison subjects. Neither gain nor any of the saccadic measures significantly differed between groups. The number of large saccades in the direction of the target was the only quantitative variable that predicted low qualitative ratings. Qualitatively poor tracking was associated with the deficit-like, but not the psychotic-like, symptoms of schizotypal personality disorder.Patients with schizotypal personality disorder demonstrate qualitatively poorer tracking than comparison groups, and the impaired tracking is associated with deficit-like symptoms.