tbuckley/cabot-search huggingface dataset:
HG-75CLINICAL, RADIOLOGICAL, AND HISTO-GENETIC CHARACTERISTICS OF LONG-TERM SURVIVORS OF DIFFUSE INTRINSIC PONTINE GLIOMA: A COLLABORATIVE REPORT FROM THE INTERNATIONAL AND SIOP-E DIPG REGISTRIES
Authors: Lindsey M. Hoffman, Sophie E.M. Veldhuijzen van Zanten, Niclas Colditz, Joshua Baugh, Brooklyn Chaney, Adam Lane, Christine Fuller, Lili Miles, Cynthia Hawkins, Ute Bartels, Eric Bouffet, Stewart Goldman, Sarah Leary, Nicholas K. Foreman, Roger Packer, Katherine E. Warren, Alberto Broniscer, Mark W. Kieran, Jane Minturn, Melanie Comito, Emmett Broxon, Chie-Schin Shih, Soumen Khatua, Murali Chintagumpala, Anne-Sophie Carret, Timothy Hassall, David Ziegler, Nick Gottardo, Hetal Dholaria, Brianna Lerme, Jenavieve Kirkendall, Renee Doughman, Marion Hoffmann, Matthew Wollman, Rachel O'Keefe, Martin Benesch, Nicolas Gerber, Simon Bailey, Guirish Solanki, Maura Massimino, Veronica Biassoni, Filip Jadrijevic Cvrlje, Esther Hulleman, Rachid Drissi, Javad Nazarian, Nada Jabado, Andre Oscar von Bueren, Torsten Pietsch, Gerrit H. Gielen, Dominik Sturm, David T. Jones, Stefan Pfister, Chris Jones, Darren Hargrave, Esther Sanchez, Brigitte Bison, Monika Warmuth-Metz, James Leach, Blaise Jones, Dannis G. van Vuurden, Christof M. Kramm, Maryam Fouladi
Journal: Neuro-Oncology (2016)
COMPOUND F USED ORALLY IN PATIENTS WITH RHEUMATOID ARTHRITIS
Authors: E W BOLAND, N E HEADLEY
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Further Studies on Cow Anti-HeLa Serum
Authors: Robert M. McAllister, Paul W. Grunmeier, Lewis L. Coriell, Sheldon R. Wilson, Robert R. Marshak
Journal: JNCI Journal of the National Cancer Institute (1959)

Heterologous cytotoxic activity against HeLa cells, which was produced in a cow, prevented HeLa tumors in X-irradiated cortisone-treated rats when injection was made by the same route or by a different route from that of the HeLa cells. By means of the cytotoxic metabolic inhibition test with tissue-culture cells, the cytotoxin could be traced from the peritoneum into the extracellular fluid compartment of the rat. The half life was approximately 1 day. By tumor prevention, the cytotoxin could be shown to diffuse from the blood stream back into the peritoneum. Under the conditions of the study, this heterologous cytotoxic substance, probably antibody, appears to diffuse across capillary membranes and to inhibit the gross formation of HeLa cell tumors in X-irradiated cortisone-treated rats.
Amoxicillin haptenates intracellular proteins that can be transported in exosomes to target cells
Authors: F. J. Sánchez-Gómez, J. M. González-Morena, Y. Vida, E. Pérez-Inestrosa, M. Blanca, M. J. Torres, D. Pérez-Sala
Journal: Allergy (2016)

Background Allergic reactions to β-lactams are among the most frequent causes of drug allergy and constitute an important clinical problem. Drug covalent binding to endogenous proteins (haptenation) is thought to be required for activation of the immune system. Nevertheless, neither the nature nor the role of the drug protein targets involved in this process is fully understood. Here, we aim to identify novel intracellular targets for haptenation by amoxicillin (AX) and their cellular fate. Methods We have treated B lymphocytes with either AX or a biotinylated analog (AX-B). The identification of protein targets for haptenation by AX has been approached by mass spectrometry and immunoaffinity techniques. In addition, intercellular communication mediated by the delivery of vesicles loaded with AX-B-protein adducts has been explored by microscopy techniques. Results We have observed a complex pattern of AX-haptenated proteins. Several novel targets for haptenation by AX in B lymphocytes have been identified. AX-haptenated proteins were detected in cell lysates and extracellularly, either as soluble proteins or in lymphocyte-derived extracellular vesicles. Interestingly, exosomes from AX-B-treated cells showed a positive biotin signal in electron microscopy. Moreover, they were internalized by endothelial cells, thus supporting their involvement in intercellular transfer of haptenated proteins. Conclusions These results represent the first identification of AX-mediated haptenation of intracellular proteins. Moreover, they show that exosomes can constitute a novel vehicle for haptenated proteins, and raise the hypothesis that they could provide antigens for activation of the immune system during the allergic response.
Food-borne Clostridium botulinum intoxication from mass produced foodstuffs in Europe
Authors: J Cowden
Journal: Eurosurveillance (2011)

Preview this article: Food-borne Clostridium botulinum intoxication from mass produced foodstuffs in Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/49/art20033-en-1.gif
bmjlearning.com: Reusable learning objects
Authors: Kieran Walsh
Journal: BMJ (2006)

Does your institution or medical school have online learning resources? If you are lucky then you may have access to a wealth of online learning modules or objects, but if you're in a poor institution then you probably wont. But no matter how big your institution, it's a fair guess that its online learning resources will have at least some gaps. How should you fill them?

One possibility would be for all medical schools everywhere to share their online learning resources. This is the idea of Ron Harden, and he and his team in Dundee are building an “International Virtual Medical School” (IVIMEDS).1 They say that learning content can be split into objects and then tagged and recombined to form teaching and learning experiences. For example, if you are giving a lecture on pneumonia in London then you can download a chest x ray from New York to put in your presentation. So the idea is taking things apart, tagging them, and then putting them back together again.

This seems to make sense, but there are caveats. Donald Clark of the e-learning company Epic is sceptical and wonders why no other medium has adopted the idea of “learning objects”: the film industry doesn't divide films into individual scenes and then allow viewers to put them back together again.2 Certainly, context is everything when writing learning modules: the job of the writer is to make meaningful narratives from which people can learn. If you take away the narrative then you may lose everything. And will the learning objects that you download “fit” with the rest of your presentation? Proponents of reusable learning objects often compare them to Lego bricks—you can reuse the bricks to make whatever you want. But Lego is produced by only one company and can't be combined with anyone else's bricks. Sceptics say that you may be left with a bunch of learning objects that don't fit well together.

The truth is that the jury is still out on learning objects and their reusability. But there is no doubt that in the medical world IVIMEDS has taken the concept further than anyone else. If you are interested you can see some of their work at www.ivimeds.org/home.html.

Meanwhile, at BMJ Learning one of our most recent modules is on the red eye. It is packed to the brim with learning objects—mainly pictures of patients with acute glaucoma and bacterial and viral conjunctivitis. The authors have kindly told us that we can reuse them occasionally in other learning resources, but how well they fit together we shall have to wait and see.
Use of radionuclide bone scans in multicenter clinical trials: Opportunities for quality improvement
Authors: A. Lovell, R. Ford, T. Monninger, E. Perlman
Journal: Journal of Clinical Oncology (2009)

e17534 Background: Radionuclide bone scans are widely utilized to screen for osseous metastases given their high sensitivity for detection of metastatic disease. However, the variance in image quality can significantly impact the diagnostic interpretation. Methods: Prospective assessment of image quality on 478 digital and hard copy planar bone scans received as part of several multi-center clinical trials was completed using a two reviewer paradigm. To improve image quality, the following steps were taken: an Internal Image Quality Task Committee was formed, a comprehensive training program for all internal quality control reviewers was completed, and a site qualification process was initiated prior to site selection and/or subject enrollment with direct feedback to the sites. Results: Significant image quality issues potentially limiting the diagnostic interpretation of the radionuclide scans were initially identified in 21% of the submitted radionuclide bone scans. Quality issues were based on: technical factors, poor imaging technique, and subject factors which could not be corrected. A discordance rate of 4.3% among the two reviewers was also measured. After institution of the above steps, the net result was a 58% decrease in the quality control issues that were previously identified. The most significant improvements occurred on the basis of the site qualification process where sites changed from sending hard copy to digital images and there was direct feedback from the Imaging Core Lab to the sites to correct identified issues. Conclusions: Image quality of bone scans in multicenter clinical trials can be improved with direct communication coupled with a site qualification process prior to subject enrollment. We suspect these quality improvements will impact event driven endpoints that rely on the accurate assessment of bone lesions. We further suspect this level of quality control will continue to increase in importance as technology evolves to include hybrid scanning techniques such as SPECT/CT. This parallels our experience in the level of quality control and site qualification required for deployment of FDG-PET imaging in multicenter clinical trials. [Table: see text]
HG-91TOPOGRAPHIC HISTOLOGICAL AND MOLECULAR STUDIES OF DIFFUSE INTRINSIC PONTINE GLIOMA TREATED WITH CONVECTION ENHANCED DELIVERY
Authors: Michael Lin, Eshini Panditharatna, Madhuri Kambhampati, Cheng-Ying Ho, Suresh Magge, Robert Keating, Roger Packer, Mark Souweidane, Javad Nazarian
Journal: Neuro-Oncology (2016)
<i>Ascaris Lumbricoides</i>in the Stomach
Authors: S Vernace, C Maltz
Journal: Endoscopy (2003)

Figure 1 An 81-year-old Chinese-born man, with a history of lung cancer for which he had received both radiation and chemotherapy, underwent upper endoscopy for odynophagia. When the stomach was entered, a motile tubular structure with tapered ends and approximately 6 mm diameter and 20 cm length was noted. This had the appearance of Ascaris lumbricoides. The patient was treated with one dose of albendazole without effect on his symptoms.
Analysis of junctional diversity in the preferential V delta 1-J delta 1 rearrangement of fresh T-acute lymphoblastic leukemia cells by in vitro gene amplification and direct sequencing
Authors: E Macintyre, L d'Auriol, F Amesland, P Loiseau, Z Chen, L Boumsell, F Galibert, F Sigaux
Journal: Blood (1989)
Website of the Week: Indigenous health
Authors: Upasana Tayal
Journal: BMJ (2003)

Health Unlimited is a British non-governmental organisation that develops long term projects in remote, often war torn, areas alongside communities and health service providers to help women and children to achieve better health and wellbeing (www.healthunlimited.org). The organisation gives priority to indigenous people and communities affected by conflict and political instability, and has just published a report that says that indigenous people worldwide are unable to access routine health care and are dying prematurely (p 413).

Health Unlimited's website contains information about the organisation's activities in Africa, Asia, and Latin America. In the African Great Lakes region, for example, Health Unlimited runs the Well Women Media Project, which produces interactive radio and television programmes, such as Urunana (Hand in Hand), a radio soap opera that is followed by an agony aunt slot highlighting the issues raised in the drama. The programme is written and produced in Rwanda and goes out twice a week through the BBC Great Lakes Lifeline Service and Radio Rwanda. Issues covered include HIV and AIDS, domestic violence, female genital mutilation, birth spacing, girls' rights to education, and income generation for women.

The international medical aid organisation Medecins Sans Frontieres also works with indigenous people. Reports of its activities in countries such as Guatemala, Panama, and Peru make compelling reading (www.msf.org/content/page.cfm?articleid=038B415C-B2A6-4DDF-B4508ADE4E913684).

There are surprisingly few other good sites on indigenous health. Most focus on Australia or New Zealand and are of variable quality. One worthy exception is Australian Indigenous HealthInfoNet (www.healthinfonet.ecu.edu.au). The site is run by a small team of health researchers, multimedia staff, and a librarian. It contains summaries, reviews, and overviews of indigenous health, as well as a useful list of frequently asked questions. The group also works directly with indigenous people to improve their use of the internet.
Hormonal modulation of ionic permeability in human red blood cells.
Authors: R D London, L Berson, M S Lipkowitz
Journal: Journal of the American Society of Nephrology (1993)

It has previously been reported that both exogenous adenosine cAMP analogs and forskolin-induced elevations in intracellular cAMP concentrations selective increase relative ionic chloride permeability in normal human red blood cells (RBC). A similar selectively increase in relative ionic chloride permeability was observed in untreated uremic subjects in whom endogenous RBC cAMP concentrations are chronically elevated. To detect which hormones might modulate RBC cAMP and ionic permeabilities, RBC were exposed to norepinephrine, epinephrine, and parathyroid hormone. Thereafter, RBC cAMP concentrations were measured by RIA and relative ionic permeabilities were determined in human RBC ghosts with the potential sensitive fluorescent probe diS-C3-(5). In ghosts prepared from normal RBC, norepinephrine and epinephrine significantly increased intracellular cAMP concentrations; in these ghosts, relative ionic chloride permeability (permeability of chloride/permeability of potassium (PCI/PK)), but not PNa/PK (permeability of sodium/permeability of potassium), was significantly increased. In contrast, exposure to parathyroid hormone did not affect either cAMP concentrations or relative ionic permeabilities. These results are consistent with the presence of adrenergic receptors and the absence of parathyroid hormone receptors in RBC. These studies demonstrate that hormonally induced changes in cAMP can modulate RBC relative ionic chloride permeability and suggest that, in uremic RBC, increased relative ionic chloride permeability could be consequent to elevated plasma levels of epinephrine or norepinephrine.
A memorable patient: ...or two
Authors: David A Churchill
Journal: BMJ (2005)

As a young junior partner in a general practice in southern England in the 1970s, I was about to go out on a Saturday morning in the middle of February to make an unusually large number of home visits, a result of the winter flu outbreak that was putting enormous pressure on GPs and hospitals alike. The details of almost every visit simply read: “Very high temperature.”

As I left the surgery, complaining at the length of the list, my wise senior partner (I had been his trainee) simply smiled benignly and said, “The trick today, David, will be to pick out the ones who have malaria and only spend two minutes on the ones with flu.” (He had previously spent some time in Africa.) His flippant remark was not well received.

That afternoon, I visited one of those on my list—a young man lying on top of his bedclothes in a white towelling dressing gown, which contrasted strongly with his very sun-tanned skin that was quite out of place in an English winter. I asked where he had got his tan. He replied that he had just come back from Africa.

The duty haematologist at the local hospital clearly thought I was completely mad in asking him to screen for malarial parasites, but agreed to do so in view of the patient's history. Not long after receiving the specimens, he telephoned me. The patient did indeed have malaria, and the house physician—after initially announcing that there was a bed shortage and querying whether a young man with a fever really needed to come in—soon agreed to admit my patient, happy that a diagnosis was already in the bag.

Later in the evening, another young man telephoned to ask for a home visit: he ached all over and had high fever. In a rash moment, I said, “No problem, I will pop round and see you. It's either flu or malaria—there's a lot of that about this weekend.”

The silence at the other end of the line—which I initially interpreted as the patient not appreciating my particular brand of humour—was soon followed by the anxious reply, “I have just come back from Africa; you don't really think it's malaria, do you?”

The duty haematologist at the local hospital thought I was joking when I requested yet more urgent tests for malaria, and I was as surprised as he was when I had to admit my second falciparum malaria of the weekend. The houseman had the two patients in two adjacent beds on his ward, and both made a good recovery. My reputation as a good diagnostician certainly grew—but how different it might have been if my wise former trainer had not thrown me his humorous challenge as I went out on my calls.
Child Intelligence and Reductions in Water Arsenic and Manganese: A Two-Year Follow-up Study in Bangladesh
Authors: Gail A. Wasserman, Xinhua Liu, Faruque Parvez, Pam Factor-Litvak, Jennie Kline, Abu B. Siddique, Hasan Shahriar, Mohammed Nasir Uddin, Alexander van Geen, Jacob L. Mey, Olgica Balac, Joseph H. Graziano
Journal: Environmental Health Perspectives (2015)

Arsenic (As) exposure from drinking water is associated with modest intellectual deficits in childhood. It is not known whether reducing exposure is associated with improved intelligence.We aimed to determine whether reducing As exposure is associated with improved child intellectual outcomes.Three hundred three 10-year-old children drinking from household wells with a wide range of As concentrations were enrolled at baseline. In the subsequent year, deep community wells, low in As, were installed in villages of children whose original wells had high water As (WAs ≥ 50 μg/L). For 296 children, intelligence was assessed by WISC-IV (Wechsler Intelligence Scale for Children, 4th ed.), with a version modified for the study population, at baseline and approximately 2 years later; analyses considered standardized scores for both Full Scale IQ and Verbal Comprehension, Perceptual Reasoning, Working Memory, and Processing Speed Indices. Creatinine-adjusted urinary arsenic (UAs/Cr), blood As (BAs), and blood manganese (BMn) were assessed at both times.UAs/Cr concentrations declined significantly by follow-up for both the high (≥ 50 μg/L) and low (< 50 μg/L) WAs subgroups. At baseline, adjusting for maternal age and intelligence, plasma ferritin, head circumference, home environment quality, school grade, and BMn, UAs/Cr was significantly negatively associated with Full Scale IQ, and with all Index scores (except Processing Speed). After adjustment for baseline Working Memory scores and school grade, each 100-μg/g reduction in UAs/Cr from baseline to follow-up was associated with a 0.91 point increase in Working Memory (95% CI: 0.14, 1.67). The change in UAs/Cr across follow-up was not significantly associated with changes in Full Scale IQ or Index scores.Installation of deep, low-As community wells lowered UAs, BAs, and BMn. A greater decrease in UAs/Cr was associated with greater improvements in Working Memory scores, but not with a greater improvement in Full Scale IQ.Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Kline J, Siddique AB, Shahriar H, Uddin MN, van Geen A, Mey JL, Balac O, Graziano JH. 2016. Child intelligence and reductions in water arsenic and manganese: a two-year follow-up study in Bangladesh. Environ Health Perspect 124:1114-1120; http://dx.doi.org/10.1289/ehp.1509974.
PNR-04NOVEL MANAGEMENT OF A NEUROGLIAL HAMARTOMA/GANGLIOGLIOMA WITH CHEMOTHERAPY AND PET IMAGING: TWO CASE REPORTS
Authors: Beryl Lin, Ignacio Gonzalez, Stacie Stapleton
Journal: Neuro-Oncology (2016)

PNR-04. NOVEL MANAGEMENT OF A NEUROGLIAL HAMARTOMA/GANGLIOGLIOMA WITH CHEMOTHERAPY AND PET IMAGING: TWO CASE REPORTS Beryl Lin1,3, Ignacio Gonzalez2, and Stacie Stapleton2,3; University of New South Wales, Sydney,NSW, Australia; All Children’s Hospital, St Petersburg, FL,USA; JohnsHopkinsUniversitySchool ofMedicine, Baltimore,MD,USA INTRODUCTION: Neuroglial hamartomas of the cerebellopontine angle (CPA) are extremely rare tumours of the CNS, with only 12 prior cases in the literature. Curative resection is not always achievable, and few studies have examined the utility of adjuvant therapies. We present two unusual cases of very symptomatic, non-excisable pontine hamartoma/gangliogliomas and a novel approach to their imaging and treatment. CASE REPORT: Patient 1 is a 9-year old boy who presented with vertigo and hearing loss. MRI revealed a 25x10mm right CPA mass. Despite aggressive subtotal resection of his hamartoma/ganglioglioma, the patient continued to develop severe headaches and tremors that significantly impacted his quality of life. Patient 2 is 9-month-old boy who presented with hemifacial spasms. EEG was normal however, MRI revealed a similar 3x3x2cm left CPA mass, proven on biopsy to be a hamartoma/ ganglioglioma. Both patients, despite stable evaluation upon MRI over several years, suffered life-impacting clinical deterioration. Notably, both lesions were persistently avid for F-18 FDG on PET. Two years after first presentation, patient 1 trialled non-standard treatment with chemotherapy. Within 6 months,hispontine lesionbecamenon-avidonPETwithcompletesymptomatic resolution. Currently, 6 months following a 2-year chemotherapy protocol, patient 1 has remained asymptomatic with excellent tumour control. Patient 2 declined chemotherapy. Despite stable evaluation on MRI, his spasms continue to worsen, now interfering with his speech and social interactions. CONCLUSION: To our knowledge, this is the first study to report successful use of PET neuroimaging and chemotherapy in neuroglial hamartomas/gangliogliomas for consideration in future management. Neuro-Oncology 18:iii7–iii15, 2016. doi:10.1093/neuonc/now067.4 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PCM-11MORPHINE MODULATES DOXORUBICIN UPTAKE: CYTOFLUORIMETRIC STUDY ON AN IN VITRO MODEL OF BLOOD-BRAIN BARRIER
Authors: Anna Lisa Iorio, Martina Da Ros, Maurizio Lucchesi, Milena Guidi, Carla Fonte, Claudio Favre, Lorenzo Genitori, Iacopo Sardi
Journal: Neuro-Oncology (2016)