tbuckley/cabot-search huggingface dataset:
Abstract 2159: Targeting GRB7/ERK/FOXM1 signaling cascade is a promising therapeutic approach in ovarian cancer
Authors: David W. Chan, Hextan YS Ngan
Journal: Cancer Research (2012)

Abstract Ovarian cancer is a higly mortal disease with poor prognosis and especially in high grade tumor. Emerging evidence has reported that aberrant upregulation and activation of GRB7, ERK as well as FOXM1 are closely associated with aggresivenesss of human cancers. However, the interplay between these factors in the pathogenesis of human cancers remains unclear. In this study, we found that GRB7 (P &amp;lt; 0.0001), phospho-ERK1/2 (P &amp;lt; 0.0001) and FOXM1 (P = 0.001) were overexpressed and associated with high grade ovarian cancers by immunohistochemical analysis. Intriguingly, the expressions of GRB7, phospho-ERK and FOXM1 showed a significant stepwise increase pattern along Grade 1 to Grade 3 ovarian cancer (P &amp;lt; 0.001). Biochemical studies using western blot analysis demonstrated that enforced expression of GRB7 could elevate the expressions of phospho-ERK and FOXM1, while enforced expression of FOXM1 could not alter levels of GRB7 and phospho-ERK. However, inhibition of ERK signaling by U0126 or PD98059 reduced the level of FOXM1 in GRB7-overexpressing ovarian cancer cells, suggesting that GRB7, ERK and FOXM1 are regulated orderly. Moreover, inhibition of ERK activity by U0126 or decreased FOXM1 expression by thiostrepton significantly inhibited cancer cell growth in vitro and in vivo. Collectively, our findings suggest that targeting GRB7/ERK/FOXM1 signaling cascade is a promising molecular therapeutic choice in combating ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2159. doi:1538-7445.AM2012-2159
Video capsule endoscopy in familial adenomatous polyposis: capsule entrapment in an anal stenosis
Authors: Franziska Durchschein, Florian Schreiber, Christoph Högenauer
Journal: Endoscopy (2014)

A 44-year-old woman with familial adenomatous polyposis syndrome underwent video capsule endoscopy (VCE) (Pillcam SB2, 11.0 mm diameter; Given, Yoqneam, Israel) for suspected small-bowel adenomas. She had undergone proctocolectomy with ileoanal pouch anastomosis 13 years earlier to treat colon carcinoma. During the day of the VCE exam, endoscopy of the ileoanal pouch was performed showing a stenosis of the anal canal ([Fig. 1]). Symptoms of this stricture had not been reported by the patient. A digital rectal exam was impossible as a result of the stenosis; however, the stricture could be passed with an endoscope of 9.8 mm diameter (Olympus GIF-H180). The pouch and neoterminal ileum showed no further abnormalities. Approximately 36 hours after administration of the video capsule, the patient developed abdominal pain. An abdominal computed tomography (CT) scan showed mechanical bowel obstruction as a result of capsule entrapment in the anal stenosis ([Fig. 2 a, b]). In a subsequent lower endoscopy, the retained capsule was recovered with a net retriever ([Fig. 3]), and the patient's obstructive symptoms resolved after the capsule's salvage. At 16-month follow-up, the patient remained asymptomatic from the anal stenosis.
AORTIC DISSECTION FOLLOWING PERCUTANEOUS CORONARY INTERVENTION FOR ACUTE CORONARY SYNDROME: A POPULATION BASED OUTCOMES STUDY OF 777,595 PATIENTS FROM THE NATIONWIDE INPATIENT SAMPLE DATABASE (2001-2010)
Authors: Christine Lau, Krishnaraj Mahendraraj, Ronald Chamberlain
Journal: Journal of the American College of Cardiology (2015)
VASA VASORUM NEOVASCULARIZATION PREDICTS PERI-PROCEDURAL MYOCARDIAL INJURY AFTER SUCCESSFUL CORONARY STENTING IN PATIENTS WITH STABLE ANGINA
Authors: Kobayashi Yusuke, Teruyoshi Kume, Ryotaro Yamada, Terumasa Koyama, Kenzo Fukuhara, Yutaka Goryo, Hiroshi Okamoto, Koichiro Imai, Yoji Neishi, Shiro Uemura
Journal: Journal of the American College of Cardiology (2016)
Solitary Subcutaneous Gouty Nodule Mimicking Metastatic Melanoma on FDG PET/CT
Authors: Kristin W Edwards, Mohan Doss, Min Huang, Shelly B Hayes, Rohit Walia, Jian Q Yu
Journal: Clinical Nuclear Medicine (2015)

A 68-year-old man with a history of malignant melanoma in the right axilla underwent FDG PET/CT. The images demonstrated a focally increased activity in the subcutaneous tissue anterior to the distal left tibia, suggestive of metastasis. However, a gouty tophus was diagnosed pathologically after biopsy.
CYSTATIN C AS A PREDICTOR OF ALL-CAUSE AND CARDIOVASCULAR MORTALITIES IN PATIENTS WITHOUT CHRONIC KIDNEY DISEASE UNDERGOING PERCUTANEOUS CORONARY INTERVENTION
Authors: Harumi Katoh, Kazushige Kadota, Suguru Otsuru, Daiji Hasegawa, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazuaki Mitsudo
Journal: Journal of the American College of Cardiology (2015)
P146Cardioprotection by consecutive isoproterenol/adenosine treatment at clinically relevant concentrations in aged and in failing heart
Authors: I Khaliulin, AP Halestrap, AF James, SM Bryant, MS Suleiman
Journal: Cardiovascular Research (2014)

Purpose: We have recently discovered that consecutive treatment of heart with isoproterenol and adenosine (Iso/Ade treatment), with a high dose of Iso (200 nM), confers strong protection against ischemia and reperfusion injury. Here we investigate whether this effect can be achieved at clinically relevant dose of Iso and identify the mechanism responsible of this intervention. This intervention has further been investigated using aged hearts and hearts with surgically-induced heart failure. Methods: Isolated rat hearts were perfused sequentially with 5 nM Iso and 30 μM Ade followed by 0, 5, or 10 min washout prior to 30 min ischemia and 2 hrs reperfusion. Ischaemia/reperfusion injury was assessed by measuring haemodynamic function, lactate dehydrogenase (LDH) release and infarct size. Protein kinase C (PKC) and glycogen content were also measured in these hearts. Additional experiments were carried out in the presence or absence of Cyclosporine A (CsA), a mitochondria permeability transition pore (MPTP) inhibitor. Heart failure was induced by ligation of the left descending anterior coronary artery in 2 months old rats. Heart failure was developed after 16 weeks post-surgery. Sham operated rats served as control. These hearts were subjected to Iso/Ade treatment at clinically relevant concentrations of the drugs followed by ischaemia and reperfusion. The efficacy of this intervention was also tested in 16 months old rats. Results: Iso/Ade treatment with 5 nM Iso effectively improved hemodynamic function recovery, considerably reduced LDH release, reduced infarct size, increased PKC activity and reduced glycogen content. CsA protected hearts but had no additive effect to the Iso/Ade treatment. Both failing and aged hearts were effectively protected by the Iso/Ade treatment. Conclusions: Consecutive Iso/Ade treatment can be effective at clinically relevant doses of the drugs and the cardioprotective effect of this treatment is not suppressed by age or heart failure and appears to be mediated by the inhibition of MPTP and glycogen depletion in myocardium.
Shared Decision Making — Finding the Sweet Spot
Authors: Terri R Fried
Journal: New England Journal of Medicine (2016)

Interview with Dr. Terri Fried on different approaches to shared decision making driven by different clinical circumstances. (09:56)Download The patient's role in medical decision making is often not matched to the clinical circumstances: rather than making strong recommendations when there's greater certainty and allowing patients to decide when there's greater uncertainty, we should do the opposite.
AB0763 Serum Level IL-23, IL-18, IL-17A, IL-17F, IL-12, IL-6 in Psoriatic Arthritis PSA Patients Hospitalized at the Rheumatology Clinic of Medical University in Wroclaw, Poland:
Authors: R. Sokolik, L. Korman, P. Wiland
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> IL-23, IL-12, IL-18, IL-17, IL-6 belong to the family of cytokines involved in systemic inflammation which plays a key role in the pathogenesis of psoriasis (PSO) and psoriatic arthritis (PsA).[1,2] <h3>Objectives</h3> The aim of this study was to investigate the association between serum levels of IL-23, IL-12, IL-18, IL-17, IL-6, and disease activity in PsA patients and control group. <h3>Methods</h3> The study group consisted of 55 patients with PsA (32 men and 23 women) hospitalized at the Rheumatology Clinic of Medical University in Wroclaw, Poland, between 2012 and 2013. Ten (n=10) healthy persons served as a control group. Study was performed with the permission of the Commission of Bioethics (Medical University, Wroclaw, Poland). The median age of patients was 48 years. PsA was diagnosed by the criteria recommended by CASPAR group. The average duration of PsA and PSO was 7 and 15 years, respectively. Serum levels of cytokines were assessed with ELISA test. Disease Activity Score was measured (swollen and tender joints, ESR, CRP) in addition to BASDAI, BASFI, VAS, and PASI scores. <h3>Results</h3> Mean serum levels of cytokines are depicted in the table below: We observed elevated levels of IL-23 cytokine (126,5 pg/ml) in PsA patients, which reached statistical significance (P&lt;0.05) if compared to control group (24,9 pg/ml). There were no significant differences between groups in other cytokines. We found a positive correlation between IL-6 serum levels and both OB and CRP. <h3>Conclusions</h3> In our study we have successfully demonstrated a significant increase in IL-23 serum levels in PsA patients. In addition we identified a possible link between serum levels of IL-6 and parameters of inflammatory state. These data suggest a potential role of IL-23 and IL-6 in pathogenesis of PsA. <h3>References</h3> Gottlieb A., Narang K. Ustekinumab in the treatment of psoriatic arthritis: latest findings and clinical potential. Therapeutic Advances in Musculoskeletal Disease 2013; 5(5) 277-285 Her M., Kavanaugh A. Treatment of spondyloarthropathy: the potential for agents other than TNF inhibitors. Curr Opin Rheumatol 2013, 25:455-459 <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5815
765 CHANGES IN STEM CELL MARKER EXPRESSION AFTER CHEMOEMBOLIZATION AND RECURRENCE OF HEPATOCELLULAR CARCINOMA AFTER LIVER TRANSPLANTATION
Authors: Z. Zeng, J.Y. Ren, M. Neil, J. Zhao, G. Chaturvedi, Y.P. Yang, S.A. Weinman
Journal: Journal of Hepatology (2012)
SAT0247 Social Role Participation in Patients with Ankylosing Spondylitis and Controls.
Authors: S. van Genderen, G. Plasqui, P. Jacobs, L. Heuft, J. Luime, A. Spoorenberg, S. Arends, M. Gignac, D. Lacaille, D. van der Heijde, R. Landewe, A. Boonen
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> While it is well known that patients with ankylosing spondyltis (AS) experience restrictions in worker participation, information regarding participation in other social roles is lacking. <h3>Objectives</h3> To assess and understand social role participation in patients with AS in comparison with a healthy control group using the social role participation questionnaire (SRPQ). <h3>Methods</h3> In a cross-sectional study, subjects completed the SRPQ, which assesses the influence of health on the perceived importance of 11 diverse social roles (e.g., hobbies, traveling, relationships, employment) and one global participation question, as well as the satisfaction with the role performance. All items were rated on a 5 point likert scale ranging from 1= not important /not at all satisfied to 5= very important/very satisfied. From these scores the importance satsifaction gap was calculated (importance minus satisfaction with the role performance), indicating the discordance between role salience and role performance. <h3>Results</h3> A total of 246 AS patients (mean age 51 ± 12 years; 62% males; mean disease duration of 17 ± 12 years) and 510 healthy controls (mean age 42 ± 15 years; 70% males) were included. The mean scores of importance and satisfaction with the role performance of the global participation question were 4.3 ± 0.8 and 3.0 ± 1.0, respectively for patients and 4.0 ± 0.9 and 3.6 ± 0.9, respectively for controls and were significantly different between groups for both measures <i>P</i>&lt; 0.001. The difference of the importance-satisfaction gaps between patients and controls accros social roles varied between 0 and 1.1. Figure 1 illustrates the gaps for patients and controls for all social roles seperately. <h3>Image/graph</h3> <h3>Conclusions</h3> In comparison with a healthy population, patients with AS report larger importance-satisfaction gaps except for the social role of paid work. Future studies should explore the reasons for the difference in the gap between patients and controls as well as the contribution of the concept of the importance-satisfaction gap on the satisfaction with life. <h3>Disclosure of Interest</h3> S. van Genderen: None Declared, G. Plasqui: None Declared, P. Jacobs: None Declared, L. Heuft: None Declared, J. Luime: None Declared, A. Spoorenberg: None Declared, S. Arends: None Declared, M. Gignac: None Declared, D. Lacaille: None Declared, D. van der Heijde: None Declared, R. Landewe: None Declared, A. Boonen Grant/research support from: MSD, Pfizer, Amgen, Abbott, Consultant for: Pfizer, Speakers bureau: Pfizer, UCB
P529 EFFICACY OF PROBIOTICS ON MINIMAL HEPATIC ENCEPHALOPATHY AND IMPROVEMENT IN SMALL INTESTINAL BACTERIAL OVERGROWTH AND OROCECAL TRANSIT TIME IN CIRRHOSIS: A RANDOMISED CONTROLLED TRIAL
Authors: M.K. Lunia, B.C. Sharma, S. Srivastav, S. Sachdeva
Journal: Journal of Hepatology (2014)
Relation between Serum Total Bilirubin Levels and Severity of Coronary Artery Disease in Patients with Non ST Elevation Myocardial Infarction
Authors: Ömer Şahin, Mahmut Akpek, Serhat Karadavut, Muammer Said Coşgun, Göktuğ Savaş, Bahadır Şarlı, Mehmet Güngör Kaya
Journal: Journal of the American College of Cardiology (2013)
Second Round of NCI Funds Goes to Other Institutes
Authors: Cori Vanchieri, Jennifer Flach
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Second Round of NCI Funds Goes to Other Institutes Get access Cori Vanchieri, Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar Jennifer Flach Jennifer Flach Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Pages 1145–1147, https://doi.org/10.1093/jnci/84.15.1145 Published: 05 August 1992
Abstract LB-276: Fusion transcripts in breast cancer cell lines and tumors
Authors: E. Aubrey Thompson, Yan W. Asmann, Brian M. Necela, Krishna R. Kalari, David W. Williamson, Jennifer M. Carr, Tiffany R. Baker, Gary P. Schroth, Jean-Pierre A. Kocher, Edith A. Perez
Journal: Cancer Research (2011)

Abstract The role of fusion gene transcripts such as BRC-ABL1 has been long appreciated in hematopoietic malignancies. Recent evidence from next generation sequencing projects has suggested that gene fusion events and the resultant chimaeric transcripts may be expressed in solid tumors. We have developed a novel bioinformatics analytical pipeline to detect fusion gene transcripts from paired-end mRNA-seq data. The bioinformatics tool used for fusion transcript discovery employs multiple steps of false positive filtering and nominates the fusion transcript candidates with high confidence (approaching 100%). The screening and validation of the fusion candidates were quickly carried out using the recommended primer design regions as one of the outputs of the SnowShoes-FD pipeline. This pipeline was used to analyze the transcriptome of 22 breast cancer cell lines and 9 non-transformed breast cell populations. Fifty-four fusion candidates were nominated, all of which were validated using reverse transcription PCR and Sanger sequencing. Five fusion products were predicted to have a second fusion junction point between two fusion partners. These 54 fusion transcripts consist of 103 partner genes that are involved in cell cycle and/or nuclear receptor signaling. No fusion transcripts were identified from the non-transformed breast cell lines. We subsequently analyzed a panel of primary breast tumors, 8 each HER2+, triple negative, and ER+. Fifteen novel fusion transcript candidates have been nominated. Validation and functional analysis of these candidates is in progress. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-276. doi:10.1158/1538-7445.AM2011-LB-276
Abstract 5431: PPAR alpha independent effect of fenofibrate on glioblastoma cancer metabolism.
Authors: Anna M. Wilk, Adriana M. Zapata, Jennifer R. Mullinax, Dorota D. Wyczechowska, Krzysztof Reiss
Journal: Cancer Research (2013)

Abstract Glioblastoma multiforme is the most common and aggressive primary brain tumor in adults. It is characterized by a rapid cell growth, CNS infiltration and is resistant to all known anticancer regimens. Therefore, development of effective therapies against these malignant brain tumors represents challenge for contemporary medicine. Anti-neoplastic potential of a common lipid-lowering drug, fenofibrate, is gaining a lot of attention, however, the precise mechanism of fenofibrate anti-cancer action remain to be elucidated. Fenofibric acid, which is an active metabolite of fenofibrate, is a potent agonist of peroxisome proliferator activated receptor alpha (PPARα), which transcriptional activity is expected to shift energy metabolism from glycolysis to fatty acid β-oxidation, therefore, it may be toxic to glycolytic tumor cells (Warburg effect). In parallel, to PPARα- dependent action, we have observed a strong PPARα- independent effect of fenofibrate on cancer cell energy metabolism, which was specific only to fenofibrate but not to fenofibric acid or to other PPARα agonists. We detected fenofibrate in mitochondrial membrane fractions of LN-229 cells treated with fenofibrate by using HPLC and subcellular fractionation. The accumulation of fenofibrate in mitochondrial membrane was accompanied by significant change in mitochondrial function, including loss of mitochondrial membrane potential, dramatic loss of oxygen consumption and lack of respiratory capacity measured as oxygen consumption rate (OCR). At the same time, fenofibrate increased the level of glycolysis (extracellular acidification rate, ECAR), possibly as compensation for impaired oxidative phosphorylation. In addition, fenofibrate-induced reduction of ATP levels triggered phosphorylation of AMPK and activation of autophagy. In conclusion, our results demonstrate two seemingly independent mechanisms of fenofibrate anticancer action: PPARα-dependent, which shifts cell metabolism from glycolysis to fatty acid β-oxidation and PPARα-independent, which causes accumulation of fenofibrate in cell membranes and inhibition of oxidative phosphorylation. Both mechanisms counteract to make this drug very effective against Glioblastoma tumors causing inhibition of cell growth, survival and finally leading to massive apoptosis of these practically incurable tumors. Citation Format: Anna M. Wilk, Adriana M. Zapata, Jennifer R. Mullinax, Dorota D. Wyczechowska, Krzysztof Reiss. PPAR alpha independent effect of fenofibrate on glioblastoma cancer metabolism. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5431. doi:10.1158/1538-7445.AM2013-5431 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
U.N. to Consider Smoking Ban On International Flights
Authors: F. X. Mahaney
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article U.N. to Consider Smoking Ban On International Flights Get access Francis X. Mahaney, Jr. Francis X. Mahaney, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 16, 19 August 1992, Page 1235, https://doi.org/10.1093/jnci/84.16.1235 Published: 19 August 1992
Endomicroscopie confocale par minisondes (ECM) guidée par échoendoscopie: résultats préliminaires d'une étude multicentrique internationale chez 58 patients présentant une tumeur kystique du pancréas (Protocole INSPECT)
Authors: M Giovannini, A Meining, F Caillol, G Monges, MB Wallace, H Aslanian, U Siddiqui, S Lo, J Laith, K Chang, J Hwang, M Saunders, V Konda, I Waxman
Journal: Endoscopy (2012)

Le diagnostic étiologique d'une tumeur kystique du pancréas reste difficile. Malgré le développement de l'imagerie, de l'échoendoscopie avec ponction et étude biochimique et cytologique du contenu kystique, la différentiation entre tumeur mucineuse (cystadénome et TIPMP) et tumeur non mucineuse (cystadénome séreux et simples kystes) n'est pas simple. La sensibilité de la ponction guidée par échoendoscopie varie entre 30 et 60% selon les séries mais ne permet pas de diagnostiquer les lésions ayant un potentiel dégénératif. L'ECM guidée par échoendoscopie permet d'offrir un examen microscopique en temps réel et pourrait augmenter la sensibilité du diagnostic étiologique des tumeurs kystiques.
Functional Bone Imaging in the Detection of Ischemic Osteopathies
Authors: MURDO A. MACLEOD, ALEXANDER S. HOUSTON
Journal: Clinical Nuclear Medicine (1997)

The efficiency and accuracy of a functional imaging technique in the detection of ischemic osteopathy is reviewed over a 10-year period. The study includes 161 patients who had trauma, 101 patients who had suspected Perthes disease, 43 patients who had dysbarism, and 22 patients who had renal transplants on steroid immunosuppressive therapy. After intravenous injection of 7.7 MBq kg-1 Tc-99m HDP data were collected on all patients during the first 20 minutes, accretion rate functional images were produced, and static bone scans performed after 3 hours. All patients were followed up until a definitive diagnosis (clinical and radiologic) of avascular necrosis or osteochondritis was confirmed or denied. Of the 327 patients studied, 114 had positive accretion rate images and 213 negative accretion rate images. There were 8 false-positive scan results and 2 false-negative scan results. The overall predictive accuracy was 97% (disease prevalence 33%) with a sensitivity rate of 98% and a specificity rate of 96%. The authors conclude that the technique is a valuable predictive diagnostic indicator for ischemic osteopathies.