tbuckley/cabot-search huggingface dataset:
Ombitasvir/Paritaprevir/R, Dasabuvir, and Sofosbuvir Treatment of Patients with HCV Genotype-Infection who Failed a Prior Course of DAA Therapy: The Quartz-I Study
Authors: F. Poordad, M. Bennett, T.E. Sepe, E. Cohen, R.W. Reindollar, G. Everson, R.W. Phillips, A. Siddique, J.G. Sullivan, T.D. Box, B. Fu, T. Pilot-Matias, M. Abunimeh, D.E. Cohen, Z. Younes
Journal: Journal of Hepatology (2016)
Sarcoidosis-related mortality in France: a multiple-cause-of-death analysis
Authors: Yvan Jamilloux, Delphine Maucort-Boulch, Sébastien Kerever, Mathieu Gerfaud-Valentin, Christiane Broussolle, Mireille Eb, Dominique Valeyre, Pascal Seve
Journal: European Respiratory Journal (2016)

We evaluated mortality rates and underlying causes of death among French decedents with sarcoidosis from 2002 to 2011.We used data from the French Epidemiological Centre for the Medical Causes of Death to 1) calculate sarcoidosis-related mortality rates, 2) examine differences by age and gender, 3) determine underlying and nonunderlying causes of death, 4) compare with the general population (observed/expected ratios), and 5) analyse regional differences.1662 death certificates mentioning sarcoidosis were recorded. The age-standardised mortality rate was 3.6 per million population and significantly increased over the study period. The mean age at death was 70.4 years (versus 76.2 years for the general population). The most common underlying cause of death was sarcoidosis. Sarcoidosis decedents were more likely to be males when aged <65 years. When sarcoidosis was the underlying cause of death, the main other mentions on death certificates were chronic respiratory and cardiovascular diseases. The overall observed/expected ratio was >1 for infectious disease, tuberculosis and chronic respiratory disease, and <1 for neoplasms. We observed a north-south gradient of age-standardised mortality ratio at the country level.Despite the limitation of possibly capturing the more severe cases of sarcoidosis, this study may help define and prioritise preventive interventions.
Ledipasvir/Sofosbuvir with Ribavirin for 12 Weeks is Effective and Safe in Treatment-Naïve Genotype-3 Hepatitis C-Infected Patients in Canada
Authors: J. Feld, A. Ramji, S. Shafran, B. Willems, P. Marotta, E. Huchet, M.-L. Vachon, E. Svarovskaia, K. Huang, R. Hyland, C. Yun, D. Brainard, J. McHutchison, E. Tam, R. Bailey, C. Cooper, E. Yoshida, S. Greenbloom, M. Elkhashab, S. Borgia, M. Swain
Journal: Journal of Hepatology (2016)
Proposal and Validation of a New Model to Estimate Survival for Hepatocellular Carcinoma Patients
Authors: P.-H. Liu, C.-Y. Hsu, C.-Y. Hsia, Y.-H. Lee, Y.-H. Huang, C.-W. Su, F.-Y. Lee, H.-C. Lin, T.-I. Huo
Journal: Journal of Hepatology (2016)
A Five-Day Schedule of Decitabine May Be Effective Treatment in High Risk MDS or Relapsed AML Presenting as MDS
Authors: Elena Parovichnikova, Alina Kokhno, Irina Kaplanskaya, Elena Domracheva, O. Samoylova, N. Obidina, V. Mashuk, O. Bocharnikova, Tatyana Pospelova, Valeryi Savchenko
Journal: Blood (2008)
Phosphoglycerate Mutase 1 Promotes Leukemia Metabolism by Coordinating Glycolysis and Biosynthesis, and Represnts a Therapuetic Target in Leukemia Treatment
Authors: Taro Hitosugi, Lu Zhou, Jun Fan, Martha Arellano, Hanna J. Khoury, Benjamin H. Lee, Titus Boggon, Sumin Kang, Chuan He, Jing Chen
Journal: Blood (2012)
Human Liver Explants have Enriched Pro-Inflammatory CD24- B Cell Populations
Authors: S. Purswani, G. Reynolds, Y. Liu, G. Webb, B. Wiggins, K. Aliazis, E. Triantafyllou, S. Davies, E. Liaskou, G. Hirschfield, D. Adams, Z. Stamataki
Journal: Journal of Hepatology (2016)
Association of Systolic Blood Pressure Variability With Mortality, Coronary Heart Disease, Stroke, and Renal Disease
Authors: Elvira O. Gosmanova, Margit K. Mikkelsen, Miklos Z. Molnar, Jun L. Lu, Lenar T. Yessayan, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Journal: Journal of the American College of Cardiology (2016)
Dual T cell– and B cell–intrinsic deficiency in humans with biallelic <i>RLTPR</i> mutations
Authors: Yi Wang, Cindy S. Ma, Yun Ling, Aziz Bousfiha, Yildiz Camcioglu, Serge Jacquot, Kathryn Payne, Elena Crestani, Romain Roncagalli, Aziz Belkadi, Gaspard Kerner, Lazaro Lorenzo, Caroline Deswarte, Maya Chrabieh, Etienne Patin, Quentin B. Vincent, Ingrid Müller-Fleckenstein, Bernhard Fleckenstein, Fatima Ailal, Lluis Quintana-Murci, Sylvie Fraitag, Marie-Alexandra Alyanakian, Marianne Leruez-Ville, Capucine Picard, Anne Puel, Jacinta Bustamante, Stéphanie Boisson-Dupuis, Marie Malissen, Bernard Malissen, Laurent Abel, Alain Hovnanian, Luigi D. Notarangelo, Emmanuelle Jouanguy, Stuart G. Tangye, Vivien Béziat, Jean-Laurent Casanova
Journal: The Journal of Experimental Medicine (2016)

Combined immunodeficiency (CID) refers to inborn errors of human T cells that also affect B cells because of the T cell deficit or an additional B cell–intrinsic deficit. In this study, we report six patients from three unrelated families with biallelic loss-of-function mutations in RLTPR, the mouse orthologue of which is essential for CD28 signaling. The patients have cutaneous and pulmonary allergy, as well as a variety of bacterial and fungal infectious diseases, including invasive tuberculosis and mucocutaneous candidiasis. Proportions of circulating regulatory T cells and memory CD4+ T cells are reduced. Their CD4+ T cells do not respond to CD28 stimulation. Their CD4+ T cells exhibit a "Th2" cell bias ex vivo and when cultured in vitro, contrasting with the paucity of "Th1," "Th17," and T follicular helper cells. The patients also display few memory B cells and poor antibody responses. This B cell phenotype does not result solely from the T cell deficiency, as the patients’ B cells fail to activate NF-κB upon B cell receptor (BCR) stimulation. Human RLTPR deficiency is a CID affecting at least the CD28-responsive pathway in T cells and the BCR-responsive pathway in B cells.
A TGF-B Receptor I Kinase Inhibitor, Galunisertib (LY2157299) Inhibits Hepatocellular Carcinoma Progression in in Vivo Experimental Models
Authors: C. Buccoliero, D. Consolante, F. Dituri, S. Mancarella, N. Hanafy, A. Mancinelli, P. Trerotoli, S. Leporatti, C. Pisano, G. Giannelli
Journal: Journal of Hepatology (2016)
Role of PET/TC in the pre-surgery staging of oral cavity cancers
Authors: F. Broggio, F. Crepaldi, B. Bocci, M. Violati, N. Battisti, C. Careri, S. Caldiera, C. Codecà, V. Bordin, A. Luciani, S. Zonato, G. Cassinelli, P. Foa, D. Ferrari
Journal: Annals of Oncology (2015)
Credentialing in surgical specialities: Recommendations by the Association of Surgeons in Training
Authors: Philip J. McElnay, Ciara McGoldrick, Andrew J. Beamish, Christopher Hoo, Vimal J. Gokani, Rhiannon L. Harries
Journal: International Journal of Surgery (2016)

The General Medical Council (GMC) has conducted a consultation process on its proposals for "credentialing" in postgraduate medical practice in the UK. It has been suggested that these may be used to provide formal accreditation of a doctor's competency in a certain area of practice. There are 5 main issues being consulted upon: (a) the time point in a doctor's career at which credentialing should be undertaken, (b) the scope of practice that should be included in credentials and whether this should include any competency already accredited by a Certificate of Completion of Training, (c) the funding source for the credentialing process, (d) the bodies that are entitled to award a credential, and (e) who exactly should be eligible for a credential. The Association of Surgeons in Training has commented on each issue and made recommendations to the GMC. One area of practice that has already begun a regulation process is Cosmetic Surgery, in response to the lack of defined standards and a clear training pathway. Both the GMC and Royal College of Surgeons of England have now published standards in this area and will come into effect in 2016. The impact of these on surgical training is discussed.
How to unleash mitochondrial apoptotic blockades to kill cancers?
Authors: Jing Deng
Journal: Acta Pharmaceutica Sinica B (2016)

Apoptosis, especially the intrinsic mitochondrial cell death pathway, is regulated by the BCL-2 family of proteins. Defects in apoptotic machinery are one of the main mechanisms that cells employ to evade cell death and become cancerous. Targeting the apoptotic defects, either by direct inhibition of BCL-2 family proteins or through modulation of regulatory pathways, can restore cell sensitivity to cell death. This review will focus on the aspects of BCL-2 family proteins, their interactions with kinase pathways, and how novel targeted agents can help overcome the apoptotic blockades. Furthermore, functional assays, such as BH3 profiling, may help in predicting responses to chemotherapies and aid in the selection of combination therapies by determining the mitochondrial threshold for initiating cell death.
Invasive Aspergillosis: A New Important Risk Factor On Short and Long-Term Survival of AML Patients.
Authors: Mauricette Michallet, Thomas Bénet, Samira Kraghel, Mohamad Sobh, Mohamed El Hamri, Giovanna Cannas, Franck Emmanuel Nicolini, Emmanuelle Nicolas-Virelizier, Hélène Labussière, Sophie Ducastelle, Roberto Crocchiolo, Fiorenza Barraco, Xavier Thomas, Youcef Chelghoum, Marie-Christine Nicoll, Anne-Lise Bienvenu, Florence Persat, Frédérique De Monbrison, Najeeb Fanari, Samia Madene, Philippe Vanhems
Journal: Blood (2009)
Nine-month results of the TROPICAL study: a multicenter nonrandomized study of the Cypher((TM)) sirolimus-eluting stent in the treatment of patients with an instent restenotic native coronary artery lesion
Authors: Walter Desmet, FJ Neumann, B Krozingen, E Grube, J Brachmann, K Coburg, P Presbitero, P Rubartelli, A Muegge, F Di Pede, D Fuellgraf, W Aengevaeren, L Spedicato
Journal: Circulation (2004)
Prolonged Isolated Thrombocytopenia (PIT) Is Associated with Platelet Aggregation, Which Is Affected By Endothelial Progenitor Cells (EPCs) Following Allo-HSCT
Authors: Xiao Hui Zhang, Shi-yuan Zhou, Fei-er Feng, Wei Han, Huan Chen, Lan-ping Xu, Xiao Jun Huang
Journal: Blood (2014)
Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Patients Treated with Nucleos(t)ide Analogues and Long-Term Virological Suppression
Authors: M. Fasano, L. Montrano, M. Ciarallo, B. Caccianotti, A. Giammario, A. Gioacchino, T. Santantonio
Journal: Journal of Hepatology (2016)
TNF Mediated Liver Damage is Protected by RIPK1 in Hepatitis
Authors: A. Filliol, C. Piquet-Pellorce, J.L. Seyec, V. Genet, C. Lucas-Clerc, J. Bertin, P.J. Gough, M.-T. Dimanche-Boitrel, P. Vandenabeele, M.J.M. Bertrand, M. Samson
Journal: Journal of Hepatology (2016)
Review: Omega-3 HUFAs added to antidepressant therapy may reduce depression symptoms
Authors: Gregory Simon
Journal: Annals of Internal Medicine (2016)

ACP Journal Club20 September 2016Review: Omega-3 HUFAs added to antidepressant therapy may reduce depression symptomsGregory Simon, MD, MPHGregory Simon, MD, MPHGroup Health Research Institute, Seattle, Washington, USA (G.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2016-165-6-028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationSarris J, Murphy J, Mischoulon D, et al. Adjunctive nutraceuticals for depression: a systematic review and meta-analyses. Am J Psychiatry. 2016;173:575-87. https://pubmed.ncbi.nlm.nih.gov/27113121Clinical Impact RatingsGIM/FP/GP: Mental Health: References1 Fournier JC, DeRubeis RJ, Hollon SD, et al. Antidepressant drug effects and depression severity: a patient-level meta-analysis. JAMA. 2010;303:47-53. [PMID: 20051569] Google Scholar2 Bower P, Kontopantelis E, Sutton A, et al. Influence of initial severity of depression on effectiveness of low intensity interventions: meta-analysis of individual patient data. BMJ. 2013;346:f540. [PMID: 23444423] Google Scholar Author, Article, and Disclosure InformationAffiliations: Group Health Research Institute, Seattle, Washington, USA (G.S.)This article was published at Annals.org on 6 September 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoReview: In patients with depressive disorders, EPA-predominant omega-3 HUFAs improve depression symptoms Gregory Simon Review: In patients with depressive disorders, EPA-predominant omega-3 HUFAs improve depression symptoms Gregory Simon Metrics 20 September 2016Volume 165, Issue 6Page: JC28KeywordsAntidepressantsDepressionFatty acidsFolic acidLibrariesMajor depressive disorderPatientsPsychiatry and mental healthVitaminsZinc ePublished: 20 September 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
High Efficacy of Sofosbuvir/Velpatasvir Plus GS-9857 for 12 Weeks in Treatment-Experienced Genotype 1-6 HCV-Infected Patients, Including Those Previously Treated with Direct-Acting Antivirals
Authors: E. Lawitz, K. Kowdley, M. Curry, N. Reau, M. Nguyen, P. Kwo, I. Jacobson, T.T. Tran, R. Nahass, F. Hinestrosa, R. Herring, M. Bennet, J.C. Yang, L.M. Stamm, Di An, H. Dvory-Sobol, D.M. Brainard, J.G. McHutchison, E. Schiff, M. Davis, K. Etzkorn, R.T. Chung, D. Pound, M. Rodriguez-Torres, K.R. Reddy, Z. Younes, E.J. Gane
Journal: Journal of Hepatology (2016)
Platinum-Based Chemotherapy Induces Methylation Changes in Blood DNA Associated with Overall Survival in Patients with Ovarian Cancer
Authors: James M. Flanagan, Angela Wilson, Chail Koo, Nahal Masrour, John Gallon, Erick Loomis, Kirsty Flower, Charlotte Wilhelm-Benartzi, Alexander Hergovich, Paula Cunnea, Hani Gabra, Elena Ioana Braicu, Jalid Sehouli, Silvia Darb-Esfahani, Adriaan Vanderstichele, Ignace Vergote, Caroline Kreuzinger, Dan Cacsire Castillo-Tong, G. Bea A. Wisman, Els MJJ Berns, Nadeem Siddiqui, James Paul, Robert Brown
Journal: Clinical Cancer Research (2016)

DNA damage repair can lead to epigenetic changes. DNA mismatch repair proteins bind to platinum DNA adducts and at sites of DNA damage can recruit the DNA methylating enzyme DNMT1, resulting in aberrant methylation. We hypothesised that DNA damage repair during platinum-based chemotherapy may cause aberrant DNA methylation in normal tissues of patients such as blood.
Single-Cell Transcriptome Profiling of Human Pancreatic Islets in Health and Type 2 Diabetes
Authors: Åsa Segerstolpe, Athanasia Palasantza, Pernilla Eliasson, Eva-Marie Andersson, Anne-Christine Andréasson, Xiaoyan Sun, Simone Picelli, Alan Sabirsh, Maryam Clausen, Magnus K. Bjursell, David M. Smith, Maria Kasper, Carina Ämmälä, Rickard Sandberg
Journal: Cell Metabolism (2016)

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in metabolic homeostasis and disease. However, their transcriptional characterization is still incomplete. Here, we sequenced the transcriptomes of thousands of human islet cells from healthy and type 2 diabetic donors. We could define specific genetic programs for each individual endocrine and exocrine cell type, even for rare δ, γ, ε, and stellate cells, and revealed subpopulations of α, β, and acinar cells. Intriguingly, δ cells expressed several important receptors, indicating an unrecognized importance of these cells in integrating paracrine and systemic metabolic signals. Genes previously associated with obesity or diabetes were found to correlate with BMI. Finally, comparing healthy and T2D transcriptomes in a cell-type resolved manner uncovered candidates for future functional studies. Altogether, our analyses demonstrate the utility of the generated single-cell gene expression resource.
Enhanced Liver Fibrosis (ELF) Test Quantification in HBeAg-Negative Patients with Nucleos(T)Ide Analogues 1, 3, 5 and 8 Years after Liver Biopsy
Authors: M. Puigvehí, T. Broquetas, M. García-Retortillo, J.J. Hernández, R. Fernández, N. Cañete, S. Coll, B. Cabrero, J. Gimeno, M.D. Giménez, F. Bory, R. Solà, J.A. Carrión
Journal: Journal of Hepatology (2016)
Generation of Bioengineered Biliary Tissue Using Primary in Vitro Propagated Extra-Hepatic Cholangiocytes and Biodegradable Scaffolds
Authors: F. Sampaziotis, M.C. de Brito, S. Sawiak, E. Godfrey, D. Ortmann, A. Bertero, S. Upponi, M. Pawlowski, N. Georgakopoulos, J. Bargehr, N. Hannan, W. Gelson, G. Alexander, K. Saeb-Parsy, L. Vallier
Journal: Journal of Hepatology (2016)
Influence of vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) on prognosis of glioblastoma (GB) patients.
Authors: C. Linassier, M. Ohresser, L. Karayan-Tapon, B. Narciso, M. Wager, M. Marson, L. Moise, B. Malivoir, H. Watier, P. Francois
Journal: Journal of Clinical Oncology (2010)

2047 Background: VEGF is a potent regulator of angiogenesis and recently bevacizumab has been showed efficient in the treatment of glioblastoma. VEGF SNPs, in non coding regions, have been described as prognostic factors in various diseases, including cancer. We have investigated whether VEGF SNPs and associated haplotypes could influence prognosis of GB pts. Methods: In a prospective cohort of 69 GB patients, we studied 5 constitutional VEGF SNPs at positions -2549 (rs35569394), -460 (rs833061), -1154 (rs1570360), +405 (rs2021963) and +936 (rs3025039), using polymerase chain reaction (PCR). Two hundred and two blood donors were used as controls. Prognostic was analyzed with clinical data including age, surgical status and VEGF SNPs. Results: GB pts were 39 men, 30 women, with a median age of 63 years (range 33-81). Fifteen pts had only biopsy, 25 pts incomplete resection and 29 pts optimal resection. Fifty-five pts received chemoradiotherapy with temozolomide; 14 could receive no treatment after surgery. Genotype frequencies did not deviate significantly from those expected under the Hardy-Weinberg equilibrium hypothesis in controls and patients. A strong association was found between SNPs in 3' of the gene at positions -2549, -460, -1154, +405. Median PFS of GB patients was 189 days (95%CI 132-245) and median OS was 405 days (95%CI 264-456). In univariate analysis, pts with incomplete surgical resection or with presence of alleles -2549I (p = 0.025), -460C (p = 0.005), -1154G (p = 0.05), +405G (p = 0.012) had a worse PFS. In multivariate analysis, surgical resection and SNP at position +405 were independent prognostic factors for PFS. SNP +405 and surgery influenced OS (p = 0.017) in multivariate analysis. Conclusions: We suggest an impact of constitutional VEGF SNPs on PFS and survival of GB patients that might interact with new anti antiangiogenic therapies. No significant financial relationships to disclose.
A New Mouse Model of Sclerosing Cholangitis to Unravel the Interplay of T Cell Dependent Liver Inflammation and Bile Acid Metabolism
Authors: F.V. Glaser, B. Engel, C. John, T. Krech, S. Weidemann, A. Carambia, J. Herkel, A.W. Lohse, J. Heeren, C. Schramm, D. Schwinge
Journal: Journal of Hepatology (2016)
Patients with Liver Cirrhosis Have Similar Prevalence, but Higher Burden of Coronary Artery Disease Compared to Patients Evaluated for Angina Pectoris
Authors: K. Kazankov, K. Munk, K.A. Øvrehus, J.M. Jensen, C.B. Siggaard, B.L. Nørgaard, H. Grønbæk, H. Vilstrup
Journal: Journal of Hepatology (2016)
Bone Marrow Microcirculation Parameter Amplitude A of Contrast-Enhanced Dynamic MRI Is a Prognostic Factor for Progressive Multiple Myeloma for Patients with Low Beta2-Microglobulin.
Authors: Jens Hillengass, Klaus Wasser, Axel Benner, Stefan Delorme, Christian Zechmann, Anthony D. Ho, Hartmut Goldschmidt, Thomas Moehler
Journal: Blood (2005)
Development of a New Hepatoprotective and Proregenerative Molecule Based on Fibroblast Growth Factor 15/19
Authors: G. Álvarez-Sola, I. Uriarte, M.U. Latasa, M. Elizalde, R. Urtasun, C.M. Rodríguez-Ortigosa, J. Prieto, M.G. Fernández-Barrena, F.J. Corrales, P. Berraondo, C. Berasain, M.A. Ávila
Journal: Journal of Hepatology (2016)
Duodenal-Jejunal Bypass Liner (Endobarrier®) Treatment Improves Non-Alcoholic Fatty Liver Disease
Authors: T. Karlas, J. Feisthammel, T. Schütz, M. Blüher, S. Beer, T. Weiße, F. Lindner, V. Keim, A. Hoffmeister, J. Wiegand
Journal: Journal of Hepatology (2016)
Mood improvement from transcranial magnetic stimulation [11] (multiple letters)
Authors: J. A. Mattes, E. A. M. Schouten, A. A. L. D'alfonso, W. A. Nolen, E. H. F. De Haan, J. Wijkstra, R. S. Kahn, M. S. George, E. M. Wassermann, W. E. Williams, T. A. Kimbrell, J. T. Little, M. Hallett, R. M. Post
Journal: American Journal of Psychiatry (1999)
Comparison of next Generation Sequencing Technologies for the Comprehensive Assessment of Full-Length Hepatitis C Viral Genomes
Authors: E. Thomson, C. Ip, A. Badhan, M. Christiansen, W. Adamson, A. Ansari, D. Bibby, D. Bonsall, R. Bowden, J. Breuer, A. Brown, J. Bryant, A. Da Silva Filipe, C. Hinds, E. Hudson, P. Klenerman, K. Lythgow, J. Mbisa, J. McLauchlan, R. Myers, P. Piazza, S. Roy, A. Trebes, S. Vattipally, J. Witteveldt, P. Simmonds, E. Barnes
Journal: Journal of Hepatology (2016)
A Novel Task Shifting Model to Expand the HCV Care Continuum: The Ascend Investigation
Authors: S. Kattakuzhy, C. Gross, G. Teferi, V. Jenkins, R. Silk, E. Akoth, A. Thomas, C. Ahmed, M. Espinosa, A. Price, B. Emmanuel, E. Rosenthal, E. Wilson, L. Tang, H. Masur, S. Kottilil
Journal: Journal of Hepatology (2016)
High Serum Soluble Intercellular Adhesion Molecule 1 (ICAM-1) Concentration Is Associated with Hepatocellular Carcinoma (HCC) Development in HBV, HCV, and Non-Viral Liver Disease: Multiplex Analysis of 51 Cytokines and Other Serum Markers
Authors: V.L. Chen, O. Podlaha, J. Estevez, B. Li, A. Le, P. Vutien, E. Chang, S. Pflanz, Z. Jiang, D. Ge, A. Gaggar, M. Nguyen
Journal: Journal of Hepatology (2016)
Polyethylene Glycol - Polyethylenimine Nanoparticle-Mediated Transfection of Mir-150 Into the Leukemia Cells and Determination of the Expression Pattern Changes in Apoptosis and Cell Cycle Genes
Authors: Tugce Balci, Cigir Biray Avci, Ipek Ozcan, Sunde Yilmaz Susluer, Cagla Kayabasi, Guray Saydam, Cumhur Gunduz
Journal: Blood (2012)
Differential expression, localization and activity of MARCKS between mantle cell lymphoma and chronic lymphocytic leukemia
Authors: J Vargova, K Vargova, N Dusilkova, V Kulvait, V Pospisil, J Zavadil, M Trneny, P Klener, T Stopka
Journal: Blood Cancer Journal (2016)

Mantle cell lymphoma (MCL) is an aggressive and often-relapsing disease characterized by the clonal proliferation of CD5+ antigen-naive pre-germinal center B cells that form solid tumors and also enter the peripheral blood through a process called leukemization. MCL cells overexpress cyclin D1 owing to a t(11;14) chromosomal DNA translocation, although there also exist few MCL cases lacking these biomarkers.1 MCL co-express CD19, CD20 and CD5 antigens with chronic lymphocytic leukemia (CLL), which has many more indolent clinical outcomes, and is typically marked with leukemization. Some antigens (CD23 and CD200) are expressed in CLL, however, not in all cases.2 In addition, few CLL cases also contained the t(11;14) translocation.3 Overlapping and disease-specific features are not always reliable to distinguish between MCL and CLL, and this requires identification of additional biomarkers. MCL from CLL were not yet explored by comprehensive global approaches, despite such understanding possibly being very neat for deciphering pathogenesis and tailoring therapies of these clinically distinct diseases. Undertaking such studies is supported by recently identified CLL-upregulated RNAs for LEF1(ref. 4) or microRNA miR-155;5 or SOX11, being overexpressed in MCL, but not in CLL.2