tbuckley/cabot-search huggingface dataset:
Rituximab Maintenance Prolongs Response Duration after Salvage Therapy with R-FCM in Patients with Relapsed Follicular Lymphomas and Mantle Cell Lymphomas: Results of a Prospective Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG).
Authors: Wolfgang Hiddemann, Roswitha Forstpointner, Martin Dreyling, Martin Gramatzki, Hans-Peter Böck, Mathias Hänel, John Seymour, Manfred Planker, Ulrich Dührsen, Klaus Wilms, Martin Clemens, Wolf-Dieter Ludwig, Hannes Wandt, Rita Pasold, Michael Unterhalt
Journal: Blood (2005)
A Novel Small Molecule E-Selectin Inhibitor GMI-1271 Blocks Adhesion of AML Blasts to E-Selectin and Mobilizes Blood Cells in Nodscid IL2Rgc−/− Mice Engrafted with Human AML
Authors: Sylvia Chien, Xin Zhao, Margaret Brown, Akanksha Saxena, John T. Patton, John L. Magnani, Pamela S Becker
Journal: Blood (2012)
Digital hub cuts care home referrals to GPs by more than a third
Authors: Nigel Hawkes
Journal: BMJ (2016)

A telemedicine service run by a Yorkshire NHS trust has reduced care home referrals to GPs by 40% and ambulance calls by almost 30%.

Staff in more than 200 care homes across England are linked to a digital hub at Airedale NHS Foundation Trust in Keighley and can seek advice 24 hours a day about the health of any of their residents. The service is run by a team of senior nurses who have online access to GP patient records and can consult doctors at the trust if they need to.

The aim is to improve care and to make best use of GP and emergency facilities by reducing needless referrals. “We started off with the local population, and then on …
miRNA-487a Promotes Proliferation and Metastasis in Hepatocellular Carcinoma
Authors: Rui-Min Chang, Shuai Xiao, Xiong Lei, Hao Yang, Feng Fang, Lian-Yue Yang
Journal: Clinical Cancer Research (2016)

Abstract Purpose: Hepatocellular carcinoma (HCC) harbors highly metastatic properties, accounting for postoperative recurrence and metastasis. However, the mechanisms for metastasis and recurrence remain incompletely clear. This study aimed to investigate the role of hsa-miR-487a (miR-487a) in promoting the proliferation and metastasis of HCC and to elucidate the underlying molecular mechanisms. Experimental Design: 198 HCC samples were analyzed for association between miR-487a expression and patient clinicopathological features and prognosis. The roles of miR-487a in proliferation and metastasis were validated both in vivo and in vitro. The upstream regulator and downstream targets of miR-487a were determined using a dual luciferase reporter assay, chromatin immunoprecipitation and immunohistochemistry. Results: Our results demonstrate that upregulated miR-487a correlates with a poor prognosis for HCC patients. miR-487a enhances proliferation and metastasis of HCC cells by directly binding to sprouty-related EVH1 domain containing 2 (SPRED2) or phosphoinositide-3-Kinase regulatory subunit 1 (PIK3R1). Interestingly, miR-487a mainly promotes metastasis via SPRED2 induced mitogen activated protein kinase signaling and promotes proliferation via PIK3R1 mediated AKT signaling. Transcription of miR-487a was found to be activated by up-regulated heat shock factor 1, which we previously demonstrated to be an important metastasis-associated transcription factor in a previous study. Phosphorodiamidate morpholino oligomers effectively silenced miR-487a and inhibited HCC tumor progression in mouse models. Conclusions: Our findings show that miR-487a, mediated by heat shock factor 1, promotes proliferation and metastasis of HCC by PIK3R1 and SPRED2 binding, respectively. Our study provides a rationale for developing miR-487a as a potential prognostic marker or a potential therapeutic target against HCC. Clin Cancer Res; 23(10); 2593–604. ©2016 AACR.
Effects of CCL2/CCR2 Blockade in Acute Myeloid Leukemia
Authors: Rodrigo Omar Jacamo, Hong Mu, Qi Zhang, Dhruv Chachad, Wang Zhiqiang, Wencai Ma, Min Zhang, Po Yee Mak, Duncan Mak, Peter Ruvolo, Teresa McQueen, Scott Lowe, Johannes Zuber, Dirk Eulberg, Anna Kruschinski, Marina Konopleva, R Eric Davis, Michael Andreeff
Journal: Blood (2015)
High Bcl-2/Mcl-1 Gene Expression Ratio Identifies Molecular Sub-Groups of Multiple Myeloma Patients Extremely Sensitive to ABT-737
Authors: Linda Bodet, Catherine Pellat-Deceunynck, Patricia Gomez-Bougie, Christelle Dousset, Cyrille Touzeau, Steven Le Gouill, Hervé Avet-Loiseau, Regis Bataille, Martine Amiot
Journal: Blood (2010)
FRI0576 Economic Impact of Lower-Limb Osteoarthritis Worldwide: A Systematic Review of Cost-of-Illness Studies
Authors: J.H. Salmon, A.C. Rat, J. Sellam, M. Michel, J.P. Eschard, F. Guillemin, D. Jolly, B. Fautrel
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Lower limb osteoarthritis (OA) is an expanding public health problem owing to the aging of the population and increase in obesity prevalence. Knowledge of the economic burden is limited. <h3>Objectives</h3> An overview of the economic consequences – overall costs as well as cost breakdown (direct and indirect) – of hip and knee osteoarthritis (OA) worldwide. <h3>Methods</h3> A systematic literature search of EMBASE, MEDLINE, Scopus and Cochrane databases for articles was performed independently by 2 rheumatologists who used the same predefined eligible criteria. Papers without abstracts and in languages other than English or French were excluded. Extracted costs were converted to an annual cost and to 2013 euros (€) by using the Consumer Price Index of the relevant countries and the 2013 Purchasing Power Parities between these countries and the European Union average. <h3>Results</h3> A total of 45 abstracts were selected, and 32 articles were considered for the review. The studiedpopulations were heterogeneous: administrative, hospital and national health survey data. Annual total costs per patient ranged from 0.7 to 12 k€, direct costs per patient from 0.5 to 10.9 k€ and indirect costs per patient from 0.2 to 12.3 k€. The weighted average annual costs per patient living with knee and hip OA were 11.1, 9.5 and 4.4 k€ for total, direct and indirect costs, respectively. <h3>Conclusions</h3> This review highlights the heterogeneity of studies and lack of methodologic consensus to obtain reliable cost-of-illness estimates for lower-limb OA. However, costs induced by the disease seem substantial and deserve to be more extensively explored. <h3>Disclosure of Interest</h3> None declared
THU0340 Rheumatoid Arthritis and Systemic Lupus Erythematosus Exhibit Similar Degree of Severity of Subclinical Atherosclerosis. Results from A Cross-Sectional Study in A Population of Northwestern Spain:
Authors: L. Riancho-Zarrabeitia, A. Corrales, N. Vegas-Revenga, L. Domínguez-Casas, V. Portilla, R. Blanco, M.A. González-Gay
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Chronic inflammation plays a central role in the development of atherosclerosis, being especially relevant in patients with rheumatic diseases. Patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are more prone to suffer cardiovascular events than the general population. <h3>Objectives</h3> Our aim was to study the prevalence of subclinical atherosclerosis in patients with RA and SLE and determine the differences between these conditions. <h3>Methods</h3> We evaluated 99 SLE patients and 206 sex- and age-matched RA patients without previous history of cardiovascular events. Subclinical atherosclerosis was defined by the presence of carotid plaque according to Manheim Consensus Conference criteria and/or intima-media thickness ≥0.90 mm. Carotid ultrasonography was performed by a MyLab 70 scanner (Esaote; Genoa, Italy), equipped with 7–12 MHz linear transducer and the <i>automated software guided technique radiofrequency</i> – <i>Quality Intima Media Thickness</i> in <i>real</i>-<i>time</i> (<i>QIMT</i>, <i>Esaote</i>, <i>Maastricht</i>, <i>Holland</i>). After the univariate analysis, multivariate regression models were fitted to adjust for potential confounders. <h3>Results</h3> The mean age was 52 ± 13 years in RA and 51±13years in SLE (p=0.77). Demographic data and traditional cardiovascular risk factors are summarized in table 1. Regarding carotid plaques, there were no statistically significant differences. The frequency of carotid plaques was 40.2% among patients with RA and 44.4% in SLE patients. Bilateral plaques were present in 26% patients with RA and in 21.2% of those with SLE. An IMT ≥0.90 mm was observed in 9.8% RA patients and in 6.3% of SLE patients (p= NS). After adjusting for traditional cardiovascular risk factors and disease duration, there were no differences in the frequency of carotid plaques (OR SLE vs RA 1.52; CI 0.88–2.62) or in the frequency of IMT ≥0.90 mm (OR 0.75; CI 0.27–2.07). <h3>Conclusions</h3> The frequency of subclinical atherosclerosis is similar in patients with SLE and RA after adjusting for traditional cardiovascular risk factors. <h3>Disclosure of Interest</h3> None declared
Could Anthracycline be Replaced in Chemotherapy for Acute Myeloid Leukemia? Randomized Clinical Trial of Homoharringtonine As Frontline Agent to Treat Pediatric AML
Authors: Shuhong Shen, Xiang Wang, JingYan Tang, Huiliang Xue, Jing Chen, Yanjing Tang, Long-Jun Gu
Journal: Blood (2014)
Split-Liver Transplantation in a Child with Liver Failure Based on Chronic Graft-Versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation from the Same Donor.
Authors: Cornelia Nicole Englert, Rainer Ganschow, Matthias Beckmann, Gritta Janka-Schaub, Martin Burdelski
Journal: Blood (2006)
SP0082 Disability in Men and Women with RA. Does It Differ and Does It Matter?
Authors: M. Björk
Journal: Annals of the Rheumatic Diseases (2016)

With pharmacological advancements, early diagnosis and multi-professional treatment, many patients with RA today, have high expectations of being able to participate in valued life activities and to experience a high quality of life. It is an on going discussion if and how RA affects women and men differently. For example, in the Swedish TIRA-project (Early Interventions in Rheumatoid Arthritis), women report higher pain intensity and more participation restrictions than men. This raises the question if men and women also have different needs of rehabilitation and if rehabilitation should be tailored differently for men and women. This session will present an overview of impairments and participation restrictions of today9s women and men with RA, and how men and women express their disabilities. The session will also focus on differences between women and men and discuss how this may be expressed as different rehabilitation needs. <h3>Disclosure of Interest</h3> None declared
Increased CD271+ CXCL12 Chemokine Overproducing Mesenchymal Stromal Cells Maintain Distinctive Association with CD34+ Hematopoietic Progenitor/Stem Cells in Myelodysplastic Syndrome
Authors: Eugenia Flores-Figueroa, Sushama Varma, Kelli Montgomery, Peter L. Greenberg, Dita Gratzinger
Journal: Blood (2011)
AB0611 Ultrasound Evaluation of Hand Articular Involvement in Systemic Sclerosis Compared To Physical Examination
Authors: O. Kaloudi, C. Nannini, L. Niccoli, E. Cassarài, F. Cantini
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Musculoskeletal involvement, preferentially affecting hands and feet, represents a frequent feature and may lead to disability in patients with systemic sclerosis (SSc). The most common manifestations are arthralgia, stiffness, synovitis, and tenosynovitis. In a large multicentre study, synovitis, tendon friction rubs, and joint contractures were found in 16%, 11%, and 31% of 7286 SSc patients assessed by clinical examination <sup>1</sup>. However, several ultrasound (US) studies revealed a higher frequency of hand joint involvement <sup>2</sup>. <h3>Objectives</h3> To investigate the frequency and severity of hand joint involvement in a cohort of SSc patients evaluated by US, and to compare the results of US synovitis detection with those of physical examination. <h3>Methods</h3> Over a 6-month period, all consecutive (new and old diagnosis) SSc patients (ACR/EULAR 2013 criteria) currently followed in our center underwent clinical and US hand examination. One rheumatologist expert in musculoskeletal US performed all examinations by using Esaote Technos MPX, MyLab 40, employing high frequency (12–18 MHz) transducers. Power Doppler (PD) parameters were adjusted (range of pulse repetition frequency 400–800 Hz; frequency 7–11.1 MHz). Patients were scheduled to be examined at the same hour of the day in the same room with an ambient temperature of 21°C. Hand and wrist joints were evaluated for synovitis, tenosynovitis, calcinosis, acro-osteolysis and distal vascularization. An independent rheumatologist made the clinical examination and US examiner was blind to clinical findings. US assessment of synovitis was scored according to the OMERACT–EULAR PD composite semiquantitative scale (0–3). <h3>Results</h3> 89 patients, 79F/10M, mean age 61.11±15.1, median disease duration 160 months (min: 2,max: 492), 83 (93%) with limited SSc and 6 (7%) with diffuse SSc were recruited. Synovitis was detected in 15 (16.8%) and in 35 (40.2%) of the cases by clinical examination and US, respectively (p=0.019). PD revealed grade 1 synovitis in 19/35 (54.3%) patients, grade 2 in 14 (40%) and grade 3 in 2 (5.7%). Tenosynovitis, calcinosis and acro-osteolysis were found at US 19 (21.3%), 14 (15.7%), acro-osteolysis in 11 (12.3%) and 8 (9%), respectively. Distal vascularization was detected in 60 patients (67%). <h3>Conclusions</h3> Confirming previous studies, our results show that hand synovitis in SSc may be underestimated by clinical examination only, while US examination provides an accurate assessment of the frequency and the degree of severity of synovial inflammation. However, synovitis in our cohort of SSc patients resulted mild in the majority of the cases. <h3>References</h3> Avouac J, et al. J Rheumatol. 2010;37:1488–501.2.Cuomo G, et al. Rheumatology (Oxford) 2009;48:1414–1417. <h3>Acknowledgement</h3> None <h3>Disclosure of Interest</h3> None declared
Risk Stratification by MLL Gene Status and Outcome of Acute Lymphoblastic Leukemia in Infants: A Report from the Japan Infant Leukemia Study Group.
Authors: Daisuke Tomizawa, Katsuyoshi Koh, Jun Nagayama, Takashi Sato, Naoko Kinukawa, Keiichi Isoyama, Yoshiyuki Kosaka, Takanori Oda, Megumi Oda, Yasuhide Hayashi, Keizo Horibe, Shuki Mizutani, Eiichi Ishii
Journal: Blood (2006)
AB0679 Mardrid Sonographic Enthesis Index Scoring System Is Sensitive for Asymptomatic Peripheral Enthesitis in Early Axial Spondyloarthritis
Authors: D.F. Lin, Z.Y. Hu, M.J. Zhao, J.Y. Cao, J.R. Gu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Mardird sonographic enthesis index (MASEI) was one of the most wide used scoring systems for enthesitis not only used in spondyloarthropathy (SpA) but also in the other disease such as enthesitis in Behcet9s disease. However, no articles mentioned its role in early diagnose in the early axial SpA without peripheral syndromes yet. <h3>Objectives</h3> Our study is to find out the role of MASEI in diagnosis of early axial SpA. <h3>Methods</h3> Ultrasound was performed by 2 observers blinded to the other examinations and the final diagnosis. All cases were diagnosed as early axial SpA fulfilling 2009 classification criteria but not 1996 New York Criteria with sacroilliac X-ray and MRI.US examination referred to MASEI related regions. BASDI, ASDAS were employed to assess disease activity. MRI was synchronized done for the position with positive findings by ultrasound to make sure the accuracy of the enthesitis. <h3>Results</h3> 1) 168 early axial SpA subjects without proof for peripheral enthesitis including physical examination or past history were screened by ultrasound.47 (28.0%) were made diagnosis as perpheral enthesitis by US and 45 (25.6%) were comfirmed by MRI. Mean age of 45 was 29.3 yrs, female-male ratio was 0.36:1, and disease duration was 0.89 yr. Positive HLA-B27 patients were more than HLA-B27negative ones (4:1). 2) The average of MASEI scores were low level (7.26±2.36). No significant differences between HLA(+) and HLA(−) groups. However, the scores for male patients group was higher than female ones (Sig=0.002), especially in respect of tendon thickness, tendon structure disturbance and bone erosion (Sig=0.000,0.001, 0.011). 3) The most common US findings were the chronic presentations as bone erosion, bone calcification. (75.6%, 84.4%) which suggested the enthesis aggression in asymptomatic patinets is a long-term slow change. <h3>Conclusions</h3> Our study found MASEI assessment is good tool for early diagnosis and follow up for peripheral enthesitis in early axial SpA and the US positive findings might be earlier than the clinical presentations. <h3>Disclosure of Interest</h3> None declared
Clinical Significance of Granulocytic Sarcoma at Relapse In Adult Patients with Acute Myeloid Leukemia
Authors: Hiroaki Shimizu, Takayuki Saitoh, Takumi Hoshino, Naoko Hatsumi, Satoru Takada, Hiroyuki Irisawa, Akihiko Yokohama, Takahiro Jimbo, Hiroshi Handa, Takafumi Matsushima, Toru Sakura, Norifumi Tsukamoto, Masamitsu Karasawa, Hirokazu Murakami, Shuichi Miyawaki
Journal: Blood (2010)
Mutational Spectrum of Myelodysplastic Syndrome Malignancies Revealed by Whole Exome Sequencing
Authors: Inés Gómez-Seguí, Bartlomiej P Przychodzen, Kenichi Yoshida, Matthew Ruffalo, Andres Jerez, Hideki Makishima, Satoru Miyano, Yuichi Shiraishi, Holleh D Husseinzadeh, Edward P Evans, Naoko Hosono, Kathryn M Guinta, Thomas LaFramboise, Seishi Ogawa, Yogen Saunthararajah, Mikkael A. Sekeres, Jaroslaw P. Maciejewski
Journal: Blood (2012)
Dose-Modified Oral Chemotherapy for AIDS-Related Non-Hodgkin’s Lymphoma (AR-NHL) in East Africa.
Authors: Jackson Orem, O.W. Mwanda, P. Fu, C. Banura, J. Kakembo, A. Ness, J. Johnson, V. Subbiah, J. Bako, J. Black, E. Katongole-Mbidde, S.C. Remick
Journal: Blood (2006)
Genomic Changes Associated with Leukemic Transformation of Myeloproliferative Disorders.
Authors: Nils Heinrich Thoennissen, Norihiko Kawamata, Terra L Lasho, Tamara Weiss, Daniel Nowak, Motohiro Kato, Junko Takita, Masashi Sanada, Torsten Haferlach, Ruben A. Mesa, Ayalew Tefferi, C. Müller-Tidow, Seishi Ogawa, Phillip H Koeffler
Journal: Blood (2008)
Comparative Phosphoproteomics Study Between Obinutuzumab (GA101) Vs. Rituximab (RTX) Against RTX Sensitive/Resistant Burkitt Lymphoma (BL): Differentially Phosphorylated B Cell Receptor, Fc-Gamma Receptor, Phagocytosis and Natural Killer Cell-Mediated Cytotoxicity Signaling Pathway Proteins
Authors: Aradhana Tiwari, Delphine CM Rolland, Mona Elmacken, Janet Ayello, Carmella van de Ven, Venkatesha Basrur, Kevin Conlon, Damine Fermin, Matthew J. Barth, Christian Klein, Kojo Elenitoba-Johnson, Megan S Lim, Mitchell S. Cairo
Journal: Blood (2015)
Management of Grade 3B Follicular Lymphoma (FL) Outside Clinical Trials: A Multicentric Retrospective Analysis on Behalf of Fondazione Italiana Linfomi (FIL)
Authors: Barbara Botto, Federica Cavallo, Manuela Zanni, Antonella Anastasia, Chiara Rusconi, Annalisa Chiarenza, Angela Ferrari, Sara Rattotti, Alessandra Dondi, Marco Calabrese, Andrea Evangelista, Umberto Vitolo, Massimo Federico, Giuseppe Rossi
Journal: Blood (2015)
Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth
Authors: Aria Eshraghi, Jungyun Kim, Alexandra C. Walls, Hannah E. Ledvina, Cheryl N. Miller, Kathryn M. Ramsey, John C. Whitney, Matthew C. Radey, S. Brook Peterson, Brittany R. Ruhland, Bao Q. Tran, Young Ah Goo, David R. Goodlett, Simon L. Dove, Jean Celli, David Veesler, Joseph D. Mougous
Journal: Cell Host & Microbe (2016)
Red Blood Cells As a Novel Mediator of Chronic Inflammation in Diet-Induced Obesity: Implications for Atherosclerosis
Authors: Ramprasad Srinivasan, Danielle Coyle, Neil Batra, Victor Blanco, Wilson Tong, Mary B Palascak, Robert S. Franco, Tapan Chatterjee, David Y Hui, W. Sean Davidson, Bruce J Aronow, Theodosia A Kalfa, David Manka, Abigail Peairs, Andra Blomkalns, Neal L Weintraub, Vladimir Bogdanov
Journal: Blood (2012)
HTLV-1 Epitope (BA21) Reactivity in Rare Bone Marrow Failure Diseases
Authors: Susan Bell Nyland, Daniel J. Krissinger, Michael Clemente, Rosalyn B. Irby, Kendall Thomas Baab, Nancy Ruth Jarbadan, Lubomir Sokol, Eric Schaefer, Jason Liao, David Cuthbertson, P.K. Epling-Burnette, Ronald Paquette, Jaroslaw P. Maciejewski, Thomas P. Loughran
Journal: Blood (2010)
Etoposide Sensitivity Does Not Predict MLL Rearrangements or Risk of Therapy-Related Acute Myeloid Leukemia.
Authors: Jun Yang, Alessia Bogni, Cheng Cheng, Wasim K. Bleibel, Jean Cai, Yiping Fan, Wenjian Yang, Jose Claudio Rocha, Deqing Pei, Wei Liu, M. Eileen Dolan, Ching-Hon Pui, Mary V. Relling
Journal: Blood (2007)
Novel Heterozygous Mutation 572insA in TACI Identified in a Patient with Selective IgA Deficiency.
Authors: Satoshi Okada, Teruyuki Kajiume, Miyuki Tsumura, Kenichiro Shirao, Yoshinori Ohno, Shin’ichiro Yasunaga, Motoaki Ohtsubo, Mostafa Mofamed Sira, Hirokazu Kanegane, Toshio Miyawaki, Yoshihiro Takihara, Masao Kobayashi
Journal: Blood (2008)
The burden of trauma at a district hospital in Malawi
Authors: Z. Jaffry, L. Chokotho, W. Harrison, N. Mkandawire
Journal: International Journal of Surgery (2016)

Trauma disproportionately affects low- and middle-income countries, many of which do not have the surveillance systems required to design effective prevention and treatment strategies. The aim of this study was to establish such a system at a district hospital in Malawi. Data on all trauma patients presenting to Mulanje District Hospital from 14 April 2013 to 30 December 2014 were collected using a form based on the core minimum data points for injuries recommended by the World Health Organization and an injury severity assessment. A total of 9073 trauma cases were recorded, accounting for 3.4% of patients that presented at the hospital during this period. Of them, 56.6% were boys/men, with the average age being 22.4 (range, 0.6-98 years). Falls (53.2%), animal bites (16.6%), road traffic injuries (11.1%) and assaults (10.2%) were the most prevalent causes, the majority of the former two taking place at home. Of the patients, 94.8% were treated and sent home, 5.0% were admitted and the remaining were either referred elsewhere or died.