tbuckley/cabot-search huggingface dataset:
Men and Manuscripts
Authors: J. R. E.
Journal: Annals of Internal Medicine (1965)

Editorials1 January 1965Men and ManuscriptsJ. R. E., E. J. H.J. R. E.Search for more papers by this author, E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-62-1-165 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe principal nutrients of the annals are the manuscripts that flow into the editorial office. To judge by the record, the ANNALSis in no danger of starvation. For the calendar year just completed—1964—the total number of manuscripts received (as extrapolated at the time of writing) will have risen to a figure in excess of 700. How do we, the editors, choose, in fact, from this multitude of papers the 200 or more articles that we publish each year? The answer lies in men—the good men and true—our colleagues on the Editorial Board and the many other editorial consultants across...Reference1. HILLS LR (Fiction Editor of Esquire): Editing: or arguing, procuring, tinkering and sending things back, in Editors on Editing, edited by GROSS, GERALD, Grosset and Dunlop, New York, 1962, pp. 201-208. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byFLUORESCENT BRIGHTENING AGENTS 1 January 1965Volume 62, Issue 1Page: 165-166KeywordsNutrientsStarvation ePublished: 1 December 2008 Issue Published: 1 January 1965 PDF downloadLoading ...
PTH-282 Perineal reconstruction following abdomino-perineal excision: results from a “hub and spoke” model
Authors: K Sran, A Hainsworth, H Scott, P Nisar, R Uppal, P Bearn
Journal: Gut (2015)

<h3>Introduction</h3> Abdomino-perineal excision (APE) for anorectal malignancy, particularly following chemo-radiotherapy, is associated with a high rate of perineal wound complications. Biological meshes and tissue flaps such as Vertical Rectus Abdominis Myocutaneous (VRAM) or Inferior Gluteal Artery Perforator (IGAP) flaps can improve wound healing. Should this be carried out in the context of a district general hospital (DGH)? We present a single centre experience using such techniques in a “hub and spoke” model with the regional plastic surgical unit. <h3>Method</h3> A retrospective study of 21 patients undergoing APE for malignancy between January 2011 and June 2014 was conducted. IGAP flap reconstruction was performed by a visiting consultant plastic surgeon. Data collection included patient demographics, underlying pathology, neoadjuvant therapy and operative details, length of hospital stay, and wound complications. Patients were followed-up by both colorectal and plastic surgical teams. <h3>Results</h3> 21 patients (11 female, mean age 66 ± 12 yrs) underwent APE for cancer (20 rectal adenocarcinoma, 1 anal squamous cell carcinoma). 12 of these patients had received neoadjuvant chemo-radiotherapy. 3 patients had primary closure, 7 biological mesh-assisted, and 12 had tissue flaps (5 VRAM and 7 IGAP). Mean length of hospital stay was 15 ± 8 days. There were no major complications following primary or mesh-assisted closure of the perineum. Perineal wound complications necessitating a return to theatre were seen in 3 patients who had undergone flap closure. Each had received neoadjuvant chemo-radiation. <h3>Conclusion</h3> This data suggests that perineal reconstructions following APE for malignancy can be undertaken in a DGH setting using a “hub and spoke” model with a regional plastic surgery unit. <h3>Disclosure of interest</h3> None Declared.
AB0031 Restricted T-Cell Frequencies and Function in Patients with Rheumatoid Arthritis Revealed by a Whole Blood Stimulation Assay Using Polyclonal and Varicella Zoster Virus-Specific Stimuli
Authors: D. Schub, G. Assmann, M. Sester, T. Schmidt
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patients with rheumatoid diseases are at increased risk for infectious complications mainly due to the immunomodulatory activity of anti-rheumatic drug treatment However, knowledge on the effect of drug-treatment on the quantity and functionality of specific cellular immune responses in rheumatic patients is limited. <h3>Objectives</h3> To characterize the immunomodulatory effect of treatment regimens (DMARD vs biologicals) on CD4 T cells in patients with rheumatic diseases. <h3>Methods</h3> For quantitative and qualitative T-cell analyses, 78 patients with rheumatic diseases (59 with rheumatoid arthritis (RA), 19 with seronegative spondyloarthropathies (SPA) and 39 healthy control persons were recruited. The general capacity of antigen-specific CD4 T cells was analysed after polyclonal whole blood stimulation with the superantigen <i>Staphylococcus aureus</i> Enterotoxin B (SEB) using intracellular staining for the cytokines IFN, IL-2, and TNF. CD127, CTLA-4 and PD1 were chosen as markers for functional anergy. Stimulation with varicella zoster virus (VZV) antigens was used for analysis of virus-specific immune responses. <h3>Results</h3> Frequencies of SEB-reactive and VZV-specific CD4 T cells were decreased significantly in RA patients (p&lt;0.05 and p&lt;0.001, respectively) with median frequencies of 2.47% (IQR 2.86%) and 0.03% (IQR 0.06%) compared to healthy controls (median 3.96% (IQR 4.38%) and 0.09% (IQR 0.16%)). When stratifying results according to treatment, no differences could be observed in quantity of polyclonally stimulated T cells. In contrast, VZV-specific CD4 T-cell frequencies showed significant differences (p&lt;0.01) with a prominent reduction in patients treated with biologicals compared to healthy controls (p&lt;0.01). Interestingly, functional analysis revealed restricted functionality of SEB-reactive CD4 T cells especially in RA patients, demonstrated by restricted cytokine expression (mainly IFN) and increased expression of CTLA-4. PD-1 and CD127 expression as well as VZV-specific T-cell properties did not differ from those of healthy controls. <h3>Conclusions</h3> Patients with rheumatoid arthritis have lower frequencies of antigen-specific and polyclonal CD4 T cells, which seem to be variably affected by biologicals. Together with features of functional anergy, this may predispose towards infectious complications. Future studies should address whether individual immunomonitoring may be used to guide the dosage of immunosuppressive drugs and to identify patients at risk for infection. <h3>Disclosure of Interest</h3> None declared
Soundings: Totally transforming Auchendreich
Authors: Colin Douglas
Journal: BMJ (2006)

Here in Auchendreich we deplore the ravages of market driven healthcare reform even in England, but are not averse to learning from the remarkable skills and insights engendered by the rigours of commerce. Thus we have the best of both worlds: revitalising our daily work with the latest thinking while still retaining the uniquely dynamic ethos of the traditional Scottish public sector.

So, at the August summit of the pan-Auchendreich Clinical Leadership Forum, a powerful team from Total Logistics Corporation of Waco, Texas, brought us the most dazzling PowerPoint presentation ever seen in the Greater Auchendreich Health Board area. It covered every detail of an impressive plan: from the selection of transformational leaders to the culmination of the entire task—the embedding of a healthcare culture of permanent excellence.

In only three years the £30m (€23m; $16m) consultancy would cascade out TLC's 4As—awareness, analysis, action, and achievement—and thus totally transform all our organisational and clinical settings: from the troubled board headquarters now at Inverdreich, to our most remote psychogeriatric day hospital in Upper Dreichmuir.

A public health doctor asked if this methodology had brought equity and efficiency to health care in the United States. The chairman disallowed the question to save time for discussion of local issues. A tanned and crew-cut urologist, an army reservist, asked if the company had done any healthcare work outside the United States. The TLC lead speaker cited ongoing billion dollar projects in a prominent Middle Eastern country which, for reasons of commercial confidentiality, he could not identify. The urologist stated that he had served in Iraq, and so thought TLC might be far too busy there to help in Auchendreich for the foreseeable future.

Eventually a psychotherapist tried to restore civility by complimenting the main speaker on his presentation. This brought the urologist to his feet again. He had heard that US commanders in Iraq had banned PowerPoint from all briefings, because its use in the Pentagon had convinced politicians that the war was already won. The chairman thanked him for his contributions and closed the meeting at 9 27 pm: sadly, with no consensus reached.
Pathologic Desquamation of Oral Epithelium Examined by Electron Microscopy and Histochemistry<xref ref-type="fn" rid="fn1">2</xref>
Authors: Reidar F. Sognnaes, D.M.D., David Weisberger, D.M.D., John T. Albright, D.D.S.
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Pathologic Desquamation of Oral Epithelium Examined by Electron Microscopy and Histochemistry Get access Reidar F. Sognnaes, D.M.D., Reidar F. Sognnaes, D.M.D. Harvard School of Dental Medicine, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar David Weisberger, D.M.D., David Weisberger, D.M.D. Harvard School of Dental Medicine, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar John T. Albright, D.D.S. John T. Albright, D.D.S. Harvard School of Dental Medicine, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 3, September 1956, Pages 329–343, https://doi.org/10.1093/jnci/17.3.329 Published: 01 September 1956 Article history Received: 04 May 1956 Published: 01 September 1956
Case 16-1971
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Sheldon D. Kaufman, Albert R. Keller
Journal: New England Journal of Medicine (1971)

Presentation of Case First admission. A 21-year-old man was admitted to the hospital because of a lump in the neck.Since early childhood he had annually experienced several episodes of a cough that continued for two or more weeks, without accompanying fever, chest pain or sputum production. Six weeks before admission a nonproductive cough developed and persisted. Six days before entry he noticed a lump in the left supraclavicular region and was referred to the hospital for evaluation.There was no history of fever, chills, sweats, dyspnea, chest pain, weight loss, pruritus or pain induced by the ingestion of . . .
Case 22-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Andrea Dunaif, Robert E. Scully
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 13-year-old girl was admitted to the hospital because of amenorrhea and hirsutism.Her previous medical history was unremarkable. At the age of 10 years the menarche occurred, with generally regular cycles; each menstrual period was associated with cramps for one or two days and moderate flow for four or five days. During the year before entry she had a weight gain of 9 kg and noticed increasing hair growth on her face and nipples. Six months before entry a typical menstrual period occurred and lasted for five days; thereafter she was amenorrheic. Six weeks before admission . . .
GROWTH HORMONE AND CARBOHYDRATE METABOLISM
Authors: A Oneda
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abortion Surveillance: Preliminary Analysis—United States, 1995
Authors: H K Atrash, E P Rhodenhiser, C J Hogue, J C Smith
Journal: JAMA (1998)

The Division of Reproductive Health Center for Promotion and Education Center for Disease Control (CDC) initiated ongoing epidemic surveillance of abortion in the US in 1969 to document the numbers and characteristics of women obtaining abortion and to assist in efforts to eliminate preventable morbidity and mortality associated with abortion.  A preliminary analysis of legal abortions reported to CDC for 1982 and 1983 are reported.  In 1983 for the 1st time since 1969 the total number of legal abortions the rate per 1000 females 15-44 years and the ratio/1000 live births all declined in comparison with reported values for the previous year.  The number of legal abortions reported to CDC from the 50 states and the District of Columbia increased from 1300760 in 1981 to 1303980 in 1982 and decreased to 1268987 in 1983.  The national abortion ratio continued to decrease from 359 legal abortions/1000 live births in 1980 to 358 in 1981 354 in 1982 and 349 in 1983.  The national abortion rate of 34 legal abortions/1000 women 15-44 years dropped to 23 in 1983.  In both 1982 and 1983 as in previous years women obtaining abortions tended to be young white unmarried and to have had no live births.  In 1982 62.2% of women obtaining legal abortions were under age 25 68.5% were white 78.0% were unmarried and 57.8% had had no live births; these figures were 61.8% 67.6% 78.6% and 57.1% respectively in 1983.  An examination of the national abortion surveillance system for 1982 and 1983 suggests that the reported lower abortion ratios and rates reflect real phenomena and are not artifacts of changes in the completeness of reporting.  Curettage continued to be the primary abortion method accounting for a higher proportion in 1982 and 1983 than in previous years.  Lower proportions of abortions were performed by instillation hysterectomy and hysterotomy.  In 1982 and 1983 approximately 96% of all legal abortions were performed by curettage; about 2% were performed byinstillation and less than 0.05% were performed by hysterectomy and hysterotomy.  About half of the legal abortions were performed in the first 8 weeks of gestation; approximately 90% were performed during the first 12 weeks of gestation.  The number of legal abortion-related deaths increased from 7 in 1981 to 11 in 1982.  Mortality data for 1983 are not presented as they may be incomplete.  The death-to-case rate for legal abortion was 0.8/100000 in 1982 compared with 0.5 in 1981.  Generally the death-to-case rate has been decreasing since 1972 but increases in the abortion-related mortality rate occurred in 1977 and 1979.
SAT0375 ICOS-ICOSL Modulates Tertiary Lymphoid Organ Formation, Regulating the Lymphotoxin Pathway in an Animal Model of SjÖgren's Syndrome
Authors: J. Campos, S. Nayar, M.-M. Chung, D.R. Withers, G. Carlesso, R. Herbst, C.D. Buckley, F. Barone
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Costimulation via ICOS-ICOSL interaction is critical for germinal center reaction in secondary lymphoid organs, regulating T cell activation and maturation into cytokine-producing cells. In autoimmunity this signal has been extensively investigated and believed to contribute to the development of follicular T helper cells, autoreactive B cells and autoantibody production. Blocking ICOS-ICOSL interaction amelliorates disease in animal models of systemic lupus erythematosus and rheumatoid arthritis. <h3>Objectives</h3> To dissect the role of ICOS-ICOSL pathway in a animal model of tertiary lymphiod organ (TLO) formation that mimics Sjögren9s syndrome. <h3>Methods</h3> Submandibular glands of wild-type (wt), ICOSL, CD3ɛ and p55/75 (TNFR1) knockout (KO) mice were intra-ductally cannulated with luciferase-encoding replication-deficient adenovirus to induce TLO formation as previously described (1). A combination of immunofluorescence, quantitative RT-PCR, flow cytometry on digested salivary glands and <i>in vitro</i> mixed culture of lymphocytes and stroma were used. <h3>Results</h3> We demonstrated that early post cannulation with adenovirus ICOSL is significantly upregulated within the salivary glands of infected mice on a population of activated stromal cells that express gp38, adhesion molecules, TNFR1 and TNFR2. <i>In vivo</i> experiments in ICOSLKO, CD3ɛKO and p55/75KO revealed a dramatic defect in TLO formation and reduced levels of ectopic lymphoid chemokines. ICOSL+ stromal cells stimulated effector T cells to produce lymphotoxin alpha (LTα) that in turn stimulates production of lymphoid chemokines by TNFR1+ stromal cells. These observations were further confirmed <i>in vitro</i>, in mixed co-cultures of lymphocytes, dendritic cells and stromal cells isolated from wt and ICOSLKO mice. This mechanism was further validated by inducing TLO formation in ICOSLKO reconstituted with wt bone marrow, that as predicted, showed a similar degree of impairment in the LTα/TNFR1 pathway as observed in the ICOSLKO mice. <h3>Conclusions</h3> Collectively, these data demonstrate that ICOSL expression by stromal cells supports the up-regulation of LTα on T cells that in turn is required for chemokine expression via TNFR1 stimulation. These data provide a novel mechanism of action between ICOSL on stromal cells, ICOS on T cells and LTα pathways in the context of TLO formation. <h3>References</h3> Bombardieri, Barone et al. JI. 2012 <h3>Disclosure of Interest</h3> None declared
Randomised trials in surgery
Authors: R. Madhok
Journal: BMJ (2002)

Reducing blood transfusion BMJ 's cover and headline exaggerated importance of study's findingsEditor-The randomised controlled trial on mechanical methods of reducing blood transfusion in cardiac surgery by McGill et al is laudable, but we challenge the BMJ for highlighting this paper on the front cover with the headline: "Cell salvage reduces the need for a transfusion." 1 We believe that the journal has a responsibility not to exaggerate the perceived importance of findings, either in press releases or by other means. 2 The authors themselves highlighted the main limitations of the study in their discussion, and we believe that such declarations are important safeguards against widespread use of the described methods without further scientific evaluation.The authors comment on the high cost of transfusion, but they did not include a cost analysis in their study.We understand the risks associated with transfusion and agree that these in themselves may justify any added cost.However, introducing strict transfusion guidelines and monitoring their use is certainly a step that should precede the introduction of new equipment.We have been reinforcing transfusion guidelines for the past two years in our institution and are continuously monitoring blood transfusion in our hospital.Interestingly, when looking at a similar patient population to that of McGill et al, but lacking the research methods and statistics, we have achieved a similar decrease in use of all blood products, mainly by insuring that blood is transfused only when required and blood products given when need is documented (table).Despite our programme, blood products are still administered too often outside the hospital guidelines, and we think that we could decrease their use even further before introducing new expensive equipment to our routine practice.The BMJ 's cover may only reinforce incorrect practices by encouraging widespread use of techniques without common sense.We agree that the combination of acute normovolaemic haemodilution and cell salvage did not confer any benefit in this study, but McGill et al have not explored acute normovolaemic haemodilution as such and therefore no conclusion can be made with certainty about the absence of benefit of acute normovolaemic haemodilution itself.In the author's own words, this study adds to many others that are inconclusive because of the quality of the evidence.We believe that the BMJ 's cover, while attractive, may have mislead readers, and we therefore question the rationale behind such a decision.