tbuckley/cabot-search huggingface dataset:
SAT0090 Depression Recovery Improves the Efficacy of Rheumatoid Arthritis Treatment
Authors: T. A. Lisitsyna, D. Veltishchev, O. Seravina, O. Kovalevskaya, A. Zeltyn, V. Krasnov, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> the prevalence of stress-related depressive and anxiety disorders in rheumatoid arthritis (RA) patients (pts) is very high. Their associations with disease activity and chronic pain confirmed in several studies related to negative effects on the efficacy of rheumatoid arthritis treatment. <h3>Objectives</h3> to determine the impact of anxiety and depressive disorders recovery on the efficacy of RA treatment. <h3>Methods</h3> 125 RA pts were enrolled in this study. 86% RA pts were women with a mean age of 47.4±11.3. The disease activity was assessed by DAS28 score. 52% of RA pts had a high activity of disease (DAS28&gt;5,1). 67% RA pts were taking prednisone in mean dose 5±2.7 mg/day. 80% RA pts were taking DMARDs: most of them - methotrexate (45%) and leflunomide (21%). All patients were taking NSADs. Psychiatric disorders were diagnosed in accordance with the ICD-10. Psychiatric scales used: Hospital Anxiety and Depression Scale, Hamilton Anxiety Rating Scale, Perceived Stress Scale. <h3>Results</h3> depressive and anxiety disorders were diagnosed in 117 (93.6%) RA pts: depressive episodes had 46 (36,8%) patients, dysthymia - 41 (32,8%), adjustment disorders - 21 (16,8%), generalized anxiety disorder - 9 (7,2%). Stress events preceded the RA onset in 77,6% of pts. 44% RApts with anxiety/depressive disorders were successfully treated by antidepressants (sertraline or mianserine). 56% RApts refused from treatment of depression. Both groups of RApts (treated and not treated with antidepressants) received similar standard RAtreatment (low doses of prednisone, DMARDs and NSADs). Efficacy of RA treatment was evaluated in one year according EULAR response criteria ("good – moderate – none") using DAS28-score improvement from baseline. "Good response" was detected in 50% pts received standard RA treatment and antidepressants and 23% pts received standard RA treatment without antidepressants (p=0,024). "Moderate response" was detected in 25,5% pts received standard RA treatment and antidepressants and 23% pts received only standard RA treatment without antidepressants (p=NS). "None response" was detected in 25,5% pts received standard RA treatment and antidepressants and 54% pts received only standard RA treatment without antidepressants (p=0,013). In a linear regression model the presence of antidepressant treatment (β = 0.22, p &lt; 0.05) was independently associated with the "good response" for the RA-treatment. <h3>Conclusions</h3> the results have confirmed the improvement of RA treatment efficacy after successful depressive and anxiety disorders recovery due to antidepressants course. It may be associated as with the patient's compliance improvement, as with the direct anti-inflammatory and pain relieving effects of antidepressants. <h3>Disclosure of Interest</h3> None Declared
UTILIDAD DE LA ENDOSCOPIA DE ALTA RESOLUCIÓN Y EL NARROW BAND IMAGING PARA LA EVALUACIÓN DE LAS NEOPLASIAS DEL TRACTO GASTROINTESTINAL EN LA POLIPOSIS ADENOMATOSA FAMILIAR
Authors: M López-Cerón, Fjc Van den Broek, EM Mathus-Vliegen, KS Boparai, S Van Eeden, P Fockens, E Dekker
Journal: Endoscopy (2011)

Introducción: La clasificación de Spigelman que estratifica el riesgo de cáncer en la adenomatosis duodenal de la poliposis adenomatosa familiar (PAF) tiene limitaciones. La endoscopia de alta resolución (HRE) y Narrow Band Imaging (NBI) podrían ser de utilidad en este contexto.
Abstract 3477: Radiation impaired cell migration and wound healing after postoperative radiotherapy is mediated through inhibition of Shp2 tyrosine phosphatase
Authors: Mohan Natarajan, Sumathy Mohan, Xiangpeng Zheng, Natarajan Aravindan
Journal: Cancer Research (2011)

Abstract The influence and mechanism of the postoperative radiotherapy on wound healing process is controversial. Based on the vital role of endothelial cell migration on wound healing, this study investigated the response of endothelial cells to low-dose irradiation and the underlying mechanism. Primary vascular endothelial cells were grown to more than 90% of confluence in complete MCDB-131 medium. A wound was inflicted in the confluent monolayer exposing a cell-free zone on the plate. The cells were then exposed to acute dose of 10 cGy, 2 or 10 Gy at a dose rate of 1.29 Gy/min. The number of cells crossing the wound border and the migration distance in the wounded region were measured. Integrin signaling pathway was examined by the assay of expression of αvβ3 integrins, focal adhesion kinase (FAK) and phosphorylated FAK (tyr397), and actin fibers through immunoblotting. Confocal immunofluorescence was applied to observe the distribution and morphological alteration of FAK tyr397 and actins after radiation exposure. Also RNA samples were extracted from the radiation-treated cells and reverse transcriptase polymerase chain reaction was performed to analyze the transcription level of SHP-2 tyrosine phosphatase, the regulator of FAK. The results revealed a dose-dependent decrease in cell motility in terms of migration distance and the number of migrating cells. The migrating distance in 2 and 10 Gy exposed cells were only 0.5 and 0.1 mm, respectively compared to 3mm seen in mock irradiated control cells. With 10 Gy exposure, the expression of β3 domain of integrins was inhibited compared to the levels in other irradiated groups and the control group while there was no detectable difference in αv domain and α-actin among all groups. Although the level of total FAK was invariable, phosphor-FAK tyr397 was higher in the irradiated groups. RT-PCR analysis of SHP-2 demonstrated a significantly dose-dependent decrease in transcription of SHP-2 mRNA. These results suggested that radiation inhibited endothelial cell migration. Unlike chemical factors inducing chemotaxis through the reaction with integrins receptors and the ensuing signaling cascade, radiation-induced inhibition of cell migration could be attributing to the direct damage to SHP-2 transcription, and the subsequent accumulated phosphor-FAK abrogated the contraction of cytoskeletons. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3477. doi:10.1158/1538-7445.AM2011-3477
AB0734 Anti-sa antibody concentration does not change with disease activity in patients with rheumatoid arthritis
Authors: M. Vavrovsky, W. Klotz, M. Herold
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Anti-Sa antibodies belong to the group of autoantibodies against citrullinated proteins and peptides (ACPAs) and are found in patients with rheumatoid arthritis (RA). <h3>Objectives</h3> The aim of this study was to determine whether a correlation between the disease activity estimated by DAS-28 (disease activity score measured on 28 joints) and the antibody titer of the anti-Sa antibody exists. <h3>Methods</h3> In this retrospective study, out of 202 anti-CCP positive patients 36 anti-Sa antibody positive patients could be evaluated who had clinical examinations over a time span of 1 to 3 years. According to disease activity measured by DAS-28 in intervals of 6±2 months the disease courses of the patients were assigned to one of three groups: decreasing DAS-28 (n=25), stable DAS-28 (n=17), increasing DAS-28 (n=11). Within each group anti-Sa antibody concentrations between different time points of 6-months’ time span were compared by Wilcoxon-signed rank test. Anti Sa-antibody was determined in serum samples which were kept frozen at -20 °C until analysis. Concentration of anti-Sa antibodies was measured using a commercially available ELISA (EUROIMMUN, Lübeck, Germany) according to the instructions of the manufacturer. <h3>Results</h3> The Wilcoxon signed-rank test showed no significant difference in anti-Sa titers between different time points neither in the group of patients with ongoing improvement of disease activity, stable disease or treatment failures with increasing disease activity. Only in the group of patients with decreasing DAS-28 after 6 and 12 months a significant difference could be seen in the optical density of substrate development (p=0,020 and p=0,005). <h3>Conclusions</h3> Only in single cases a correlation was seen between disease activity and anti-Sa antibody titer. Our study indicates that anti-Sa antibody titer seems not to be a marker for disease activity in RA <h3>Disclosure of Interest</h3> None Declared
FRI0367 Microvascular findings in patients with raynaud’s disease - assessed by nailfold capillaroscopy and flow mediated dilatation
Authors: J. H. Lee, G.-T. Kim, S.-H. Baek
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Nailfold capillaroscopy (NC) represents the method to analyze microvascular abnormalities in autoimmune rheumatic diseases, but the pathophysiological link between the microvascular derangement which is seen in NC and endothelial function is yet to be discovered. <h3>Objectives</h3> We investigated the association between endothelial function which is assessed by brachial artery flow-mediated dilatation (FMD) and NC patterns in patients with Raynaud's phenomenon (RP). <h3>Methods</h3> 37 postmenopausal women with secondary RP and 23 controls suffering from hand numbness were evaluated with NC using a digital microscope at 400× and 100 × magnifications. The microvascular alterations were classified into three different patterns, early, active and late. Endothelial function was examined by brachial FMD (endothelium dependent) and response to 40 µg of sublingual nitroglycerine (NTG-induced dilatation, endothelium independent). <h3>Results</h3> There were significant capillary loop dilatation (apical width; 14.1±5.6 vs. 10.4±1.7 μm, p=0.001 and total width; 40.6±15.1 vs. 31.6±4.6 μm, p=0.002) and length (316.0±78.5 vs. 270.4±34.7 μm, p=0.004) in secondary RP compared to controls. Giant capillaries, loss of capillaries, hemorrhage and background pallor were much more prevalent in secondary RP as compared to controls (all P's&lt; 0.05). Although there were no significant differences in NTG-induced dilatation between secondary RP and controls(16.1±5.9 % vs. 19.6±9.0%, <i>P</i>=0.091), significant decreases in the FMD value (6.1±3.5% vs. 9.0±2.2%, <i>P&lt;0.001</i>) were noted. Both FMD and NTG-induced dilatation showed a significant inverse association with severity of NC findings (r=-0.355, p=0.005 and r=-0.285, p=028). <h3>Conclusions</h3> Significantly impaired endothelial function was found in secondary RP and capillary enlargement was significantly associated with endothelial dysfunction. This result might implicate that the recognition of abnormal capillaroscopic patterns in the secondary RP might be prognostic for the early detection of microvascular heart involvement. <b>Disclosure of Interest</b>: None Declared
Discrepancies between Meta-Analyses and Subsequent Large Randomized, Controlled Trials
Authors: J LeLorier, G Grégoire, A Benhaddad, J Lapierre, F Derderian
Journal: New England Journal of Medicine (1997)

Meta-analyses are now widely used to provide evidence to support clinical strategies. However, large randomized, controlled trials are considered the gold standard in evaluating the efficacy of clinical interventions.
c-erbB-2 Expression and Response to Adjuvant Therapy in Women with Node-Positive Early Breast Cancer
Authors: Hyman B. Muss, Ann D. Thor, Donald A. Berry, Timothy Kute, Edison T. Liu, Frederick Koerner, Constance T. Cirrincione, Daniel R. Budman, William C. Wood, Maurice Barcos, I. Craig Henderson
Journal: New England Journal of Medicine (1994)

The role of molecular markers in predicting the response to treatment of breast cancer is poorly defined. The Cancer and Leukemia Group B (CALGB) conducted a randomized adjuvant-chemotherapy trial (CALGB 8541) comparing three doses (high, moderate, and low) of cyclophosphamide, doxorubicin, and fluorouracil in 1572 women with node-positive breast cancer. This study (CALGB 8869) was designed to determine whether the DNA index, the S-phase fraction, c-erbB-2 expression, or p53 accumulation could be used as a marker to identify a subgroup of patients more likely than others to benefit from high doses of chemotherapy.
The Effect of Sulfanilamide Powder on the Healing of Sterile and Infected Wounds
Authors: Chester M. Jones, Marshall K. Bartlett, Anna E. Ryan, Gladys D. Drummey
Journal: New England Journal of Medicine (1943)

Original Article from The New England Journal of Medicine — The Effect of Sulfanilamide Powder on the Healing of Sterile and Infected Wounds — With Special Reference to Tensile Strength and Ascorbic Acid Content in the Scar
889 PLASMA IP10 LEVEL PREDICTS SPONTANEOUS CLEARANCE IN ACUTE HCV INFECTION
Authors: J. Grebely, J.J. Feld, T. Applegate, G. Matthews, M. Hellard, A. Sherker, K. Petoumenos, I. Shaw, B. Yeung, J.M. Kaldor, V. Cherepanov, J. Bruneau, A. Lloyd, N. Shoukry, G. Dore
Journal: Journal of Hepatology (2012)
Abstract 1826: A critical role of LincRNA-Up6 in Bcr-Abl-induced tumorigenesis.
Authors: Jilong Chen, Guijie Guo, Qingzheng Kang
Journal: Cancer Research (2013)

Abstract Long noncoding RNAs (lncRNAs) have been implicated in numerous human malignancies, including leukemia. Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) is a stem cell disease induced by Bcr-Abl hybrid gene. In an attempt to provide better understanding of the mechanisms by which Bcr-Abl mediates cellular transformation, lncRNA microarray was used to determine the differentially expressed non protein-coding genes in K562 human leukemic cells in response to disruption of Bcr-Abl expression. All the lncRNA genes whose expressions were altered by at least 2-fold were clustered and displayed. We further investigated the functional involvement of selected lncRNA genes in regulating cell proliferation, cell survival and tumor formation. Interestingly, expression of a long intergenic noncoding RNA which we named as lincRNA-Up6 was found to be greatly up-regulated by silencing the Bcr-Abl expression in K562 cells. We showed that forced over-expression of lincRNA-Up6 sensitized imatinib-induced apoptosis in Bcr-Abl transformed cells. In addition, we observed that over-expression of lincRNA-Up6 significantly inhibited K562 xenograft growth in nude mice. Furthermore, we found that lincRNA-Up6 was involved in negative regulation of STAT5-dependent expression of anti-apoptotic Bcl-XL protein. Importantly, our experiments showed that expression of lincRNA-Up6 had profound effects on signaling pathways associated with development of leukemia stem cells of CML, resulting in inhibition of Bcr-Abl-mediated tumor formation. Together, these results suggest that lincRNA-Up6 suppresses Bcr-Abl-induced tumorigenesis, and the tumor suppressor function of lincRNA-Up6 may be of significance for the development of novel therapeutic strategies for treating CML. Citation Format: Jilong Chen, Guijie Guo, Qingzheng Kang. A critical role of LincRNA-Up6 in Bcr-Abl-induced tumorigenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1826. doi:10.1158/1538-7445.AM2013-1826 Note: This abstract was not presented at the AACR Annual Meeting 2013 because the presenter was unable to attend.
P251 THERAPEUTIC USE OF A CLINICAL STAGE CCR2 INHIBITOR, CCX872, IMPROVES OBESITY ASSOCIATED STEATOHEPATITIS IN MICE
Authors: R. Parker, M.J. Walters, L. Ertle, K. Ebsworth, J. Tan, L. Sietz, J. McMahon, D. Dairaghi, J. Powers, D. Adams, J. Jaen, T. Schall
Journal: Journal of Hepatology (2014)
Weight Loss in HIV-Infected Patients
Authors: Teresa García-Benayas, Francisco Blanco, Vincent Soriano
Journal: New England Journal of Medicine (2002)

To the Editor: Muscle weakness is a common finding and an important predictor of death in patients with West Nile virus encephalitis. 1,2 Yet this important sign does not have a defined pathological basis.In monkeys, horses, and birds, West Nile virus causes poliomyelitis. [3]4][5] Our clinical and electrodiagnostic findings in three consecutive patients withThe New England Journal of Medicine Downloaded from nejm.org
Radiofrequency Catheter Modification of Atrioventricular Conduction to Control the Ventricular Rate during Atrial Fibrillation
Authors: Brian D. Williamson, K. Ching Man, Emile Daoud, Mark Niebauer, S. Adam Strickberger, Fred Morady
Journal: New England Journal of Medicine (1994)

In some patients with atrial fibrillation, the ventricular rate may be difficult to control with medications. We evaluated a radiofrequency catheter technique to modify atrioventricular conduction in atrial fibrillation in order to control the ventricular rate without creating pathologic atrioventricular block.We studied 19 consecutive patients with atrial fibrillation and uncontrolled ventricular rates refractory to drug therapy. They had had atrial fibrillation for a mean (+/- SD) of 5.5 +/- 4.9 years, had had 4.9 +/- 0.9 unsuccessful drug trials, and were 62 +/- 15 years old. Before the procedure, the maximal ventricular rate during exercise was 180 +/- 39 beats per minute. A total of 11 +/- 5 radiofrequency-energy applications were delivered to the posterior septal or midseptal right atrium, near the ostium of the coronary sinus.Successful control of the ventricular rate without pathologic atrioventricular block was achieved in 14 of the 19 patients (74 percent). Persistent third-degree atrioventricular block requiring a permanent pacemaker occurred inadvertently in four patients (21 percent). Atrioventricular conduction was intentionally ablated in one patient. The 14 patients who had successful modification of conduction had persistent reductions in maximal ventricular rate during exercise (rate at three months, 126 +/- 24 beats per minute; P < 0.01). These patients had resolution of symptoms related to rapid rates during 8 +/- 2 months of follow-up. One patient had a recurrence of a rapid ventricular rate but was again asymptomatic after a second modification procedure. One patient with dilated cardiomyopathy died suddenly, five months after a successful procedure.A catheter technique to modify atrioventricular conduction without creating pathologic atrioventricular block is feasible in the majority of patients with symptomatic atrial fibrillation and a rapid ventricular rate refractory to drug therapy.
S35 Different Early Life Factors Are Important in the Development of Atopic and Non-Atopic Asthma
Authors: E Petley, KC Pike, HM Inskip, KM Godfrey, JSA Lucas, G Roberts
Journal: Thorax (2012)

<h3>Background</h3> Many factors have been related to the development of childhood asthma but there is inconsistency between studies. <h3>Objective</h3> To understand how early life factors are linked to the development of the various asthma phenotypes at age 6 years in the Southampton Women’s Survey (SWS) children’s cohort. <h3>Methods</h3> Data was collected from 940 children and their parents, primarily through questionnaires during pregnancy and at 6m, 1, 3 and 6 years. Prevalent asthma was defined by a doctor’s diagnosis and a wheezing episode in the last year. Data was analysed using STATA v9. A relative risk analysis using a univariate approach was undertaken, followed by a multivariate analysis. <h3>Results</h3> Both maternal (RR=1.61, p=0.041) and paternal (RR=2.05, p=0.002) atopic disease increased the risk of asthma at age 6 years. The risk increased with atopy, defined as a positive skin prick test, at 3 years (RR=3.05, p&lt;0.001) and with wheeze in the first 3 years (RR=8.79, p&lt;0.001). Episodes of bronchiolitis and chest infections were associated, in a dose-dependent manner, with the risk of asthma (RR=1.50, p=0.022). Predictors in the multivariate model were wheeze in the first 3 years (RR=10.74, p&lt;0.001), atopy (RR=2.87, p&lt;0.001) and maternal atopy (RR=2.22, p=0.011).When asthma at age 6 years was split into atopic and non-atopic asthma, the predictors were very different. Atopic asthma was associated with paternal atopy (RR=4.13, p=0.002), male sex (RR=2.56, p=0.030), atopy at 3 years (RR=10.31, p&lt;0.001) and wheeze in the first 3 years (RR=5.91, p=0.004). In the multivariate analysis, the following were predictive: wheeze in the first 3 years (RR=13.55, p=0.012), atopy at 3 years (RR=10.13,&lt;0.001), paternal atopy (RR=2.97, p=0.017) and a 12 month infant dietary pattern that follows current guidelines (RR=1.79, p=0.016). For non-atopic asthma, bronchiolitis or chest infections (RR=1.76, p=0.047), wheeze in the first 3 years (RR=20.69, p=0.003) and tobacco smoke exposure at 6 years (RR=2.16, p=0.035) increased the risk. Only wheeze in the first 3 years remained in the multivariate model. <h3>Conclusions</h3> Different hereditary and early life factors modify the risk of atopic and non-atopic asthma at 6 years of age. This suggests that these two asthma phenotypes have different pathophysiologies.
P18.02 * A COMPARISON OF THE EFFECTS OF ATTENTION DEFICIT ON REHABILITATION FUNCTIONAL OUTCOMES IN BRAIN TUMOR PATIENTS AND SUBACUTE STROKE PATIENTS
Authors: H. E. Young, S. Im
Journal: Neuro-Oncology (2014)

OBJECTIVE: To evaluate the cognitive impairment of brain tumor and subacute stroke patients using computerized neuropsychological testing and determine the effects on functional outcomes of daily activity. METHODS: From April 2008 to December 2012, 55 patients (29 brain tumor patients, 26 subacute stroke patients) were enrolled. All patients were assessed with a computerized neuropsychological test. Motricity Index, Korean-mini mental status exam, and Korean-modified Barthel index scores were assessed at the beginning and end of 4-week rehabilitation. RESULTS: Functional outcomes of all patients significantly improved after rehabilitation therapy. In brain tumor patients, the initial Motricity Index, cognitive dysfunction, and visual continuous performance test correction numbers were strong predictors of initial daily activity function (R2 = 0.778, P < 0.01). The final Motricity Index and word-black test were strong predictors of final daily activity function (R2 =0.630, P < 0.01). In patients with subacute stroke, the initial Motricity Index was an independent predictor of initial daily activity function (R2 = 0.245, P = 0.007). The final Motricity Index and word black test were strong predictors of final daily activity function (R2 = 0.630, P < 0.01). CONCLUSIONS: Objective evaluation of cognitive function and comprehensive rehabilitation should be performed in brain tumor patients.