Adriamycin Cardiotoxicity
Authors: ROBERT A. MINOW
Journal: Annals of Internal Medicine (1975)

Comments and CorrectionsJune 1, 1975Adriamycin CardiotoxicityROBERT A. MINOW, M.D., JEFFREY A. GOTTLIEB, M.D., LEON FRAZIN, M.D., EFRAIN GARCIA, M.D.ROBERT A. MINOW, M.D.Search for more papers by this author, JEFFREY A. GOTTLIEB, M.D.Search for more papers by this author, LEON FRAZIN, M.D.Search for more papers by this author, EFRAIN GARCIA, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-82-6-855 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Rinehart, Lewis, and Balcerzak (1) recommend the use of systolic time intervals for the early detection of adriamycin cardiotoxicity. As they suggest, the early detection of significant cardiotoxicity would allow a more accurate decision on the dose limitation of adriamycin. Their Figure 1A suggests a continuous increase in systolic time intervals with increasing adriamycin dose, yet they only give the data on two patients. It would be more interesting to see if a dose response curve could be formed from all their cases.In eight of their nine (89%) patients who received > 300 mg/m2body surface...References1. RINEHARTLEWISBALCERZAK JRS: Adriamycin cardiotoxicity in man. Ann Intern Med 81:475-478, 1974 LinkGoogle Scholar2. BLUMCARTER RS: Adriamycin: a new anticancer drug with significant clinical activity. Ann Intern Med 80:249-259, 1974 LinkGoogle Scholar3. O'BRYANLUCETALLEY RJR: Phase II evaluation of adriamycin in human neoplasia. Cancer 32:1-8, 1973 CrossrefMedlineGoogle Scholar4. TANETCUBANASWOLLNER CEN: Adriamycin—an antitumor antibiotic in the treatment of neoplastic diseases. Cancer 32:9-17, 1973 CrossrefMedlineGoogle Scholar5. WEISSLERHARRISSCHOENFELD AWC: Bedside techniques for the evaluation of ventricular function in man. Am J Cardiol 23:577-583, 1969 CrossrefMedlineGoogle Scholar6. WEISSLERHARRISSCHOENFELD AWC: Systolic time intervals in heart failure in man. Circulation 37:149-159, 1968 CrossrefMedlineGoogle Scholar7. LEFRAKPITHAROSENHEIM EJS: A clinicopathologic analysis of adriamycin cardiotoxicity. Cancer 32:302-314, 1973 CrossrefMedlineGoogle Scholar8. GOTTLIEBBODEYSINKOVICS JGJ: An effective new 4-drug combination regimen (CY-VA-DIC) for metastatic sarcomas. Proc Am Soc Clin Oncol 15:162, 1974 Google Scholar9. BUCKNERRUDOLPHFEFER CRA: High dose cyclophosphamide therapy for malignant disease. Cancer 29:357-365, 1972 CrossrefGoogle Scholar10. JONESEWYGROVES SGB: Echocardiographic detection of adriamycin heart disease. Proc Am Soc Clin Oncol, in press Google Scholar11. MCDONALDHOBSON IE: A comparison of the relative value of noninvasive techniques—echocardiographic systolic time intervals and apex cardiography—in the diagnosis of primary myocardial disease. Am Heart J 88:454-462, 1974 CrossrefMedlineGoogle Scholar12. MINOWGOTTLIEBFREIREICH RJE: Electrocardiogram QRS voltage changes in adriamycin cardiomyopathy. Proc Am Assoc Cancer Res, in press Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Developmental Therapeutics The University of Texas System Cancer Center M.D. Anderson Hospital and Tumor Institute Houston, Texas 77025Division of Cardiology The Texas Heart Institute St. Luke's Episcopal Hospital Houston, Texas 77025 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDoxorubicin Cardiomyopathy: Evaluation by Phonocardiography, Endomyocardial Biopsy, and Cardiac CatheterizationMICHAEL R. BRISTOW, M.D., Ph.D., JAY W. MASON, M.D., MARGARET E. BILLINGHAM, M.D., JOHN R. DANIELS, M.D. June 1, 1975Volume 82, Issue 6Page: 855-857KeywordsCardiomyopathiesElectrocardiography Issue Published: June 1, 1975 PDF downloadLoading ...