tbuckley/cabot-search huggingface dataset:
P208 Behavioural feed-back education intervention to enhance adherence in patients with severe uncontrolled asthma, a randomised clinical trial
Authors: I Sulaiman, MC Mokoka, E MacHale, J Seheult, C Hughes, M Holmes, S D’arcy, T Taylor, V Rapcan, D Murphy, E Hunt, SJ Lane, A Sahadevan, G Crispino, GB Diette, A Sartini-Bhreathnach, B Cushen, I Killane, RB Reilly, RW Costello
Journal: Thorax (2016)

<h3>Background</h3> Severe asthma can be due difficult to treat asthma due to poor adherence or due to refractory asthma. Identifying poor adherence can be challenging since the methods of adherence have limitations. We developed a method of assessing adherence using Inhaler compliance assessment (INCA) device, which incorporates both identifying technique errors and time of use of the inhaler. We hypothesised that that feedback on time of use and technique of use to patients, improves adherence, compared to standard education without visual feedback. <h3>Methods</h3> This was a 3-month prospective multicentre randomised controlled stud, in which patients with severe uncontrolled asthma recruited from specialist asthma clinics were randomised to get feedback on and education using the adherence information downloaded from the INCA device or education alone. <h3>Results</h3> At the end of the study period, the mean rate of adherence for month three in the active group (n = 111) was 73% versus 63% in the control group (n = 107), p ≤ 0.01 (95% CI: difference 2.8, 17.6). Only the active group demonstrated significant reductions in the rate of technique errors missed doses, excess-doses with improvement in the habit of use. The mean AQLQ and ACT improved significantly in both groups. At the end of the study, 64 (32%) patients remained poorly controlled with persistent airflow obstruction. Of these, 39 had adherence rates &lt;80%, (mean 52%), while 25 had adherence &gt;80%, indicating refractory asthma. <h3>Conclusion</h3> Without changing patients' therapy, most of the patients' asthma control improved. Two thirds of those who remained uncontrolled required further adherence counselling. 11% of the total cohort remained unstable despite adequate adherence and hence will require step up therapy. Our study shows that adherence assessment and education using INCA feedback should be considered prior to referring patients for additional therapy.
P2.05-054 Radiation Pneumonitis; Early Diagnosis and Protein Expression Profile in NSCLC Patients
Authors: Samantha Aso, Arturo Navarro-Martin, Susana Padrones, Felipe Cardenal, Noelia Cubero, Rosa Lopez-Lisbona, Ma Dolores Arnaiz, Ramon Palmero, Ana Montes, Ernest Nadal, Maria Molina, Jordi Dorca
Journal: Journal of Thoracic Oncology (2017)
M2 Do patients and informal carers agree on symptom burden in advanced copd?
Authors: EZ Mi, EZ Mi, S Mendonca, AC Gardener, MC Farquhar
Journal: Thorax (2016)

<h3>Introduction</h3> Informal carers are a valuable source of information on patients’ symptom experiences for clinicians, and carer assessment determines decisions regarding symptom management by carers themselves. However, previous studies have reported that proxies overestimate symptom burden, particularly subjective psychological and emotional symptoms, but proxy studies in COPD are few. We sought to assess congruency between patient and carer assessment of symptom burden, and to identify factors associated with incongruence. <h3>Methods</h3> Well-characterised patients with advanced COPD and their carers (n = 117 patient-carer dyads) independently rated patients’ breathlessness, fatigue, constipation, diarrhoea, anxiety and depression on a 4-point scale, and average breathlessness in prior 24 hours using a Numerical Rating Scale (NRS). McNemar’s and Wilcoxon signed rank test were performed to identify differences between patients and carers in proportions reporting presence and reporting of severity of symptoms respectively. Intraclass correlation (ICC) was used to assess agreement on symptom scores in dyads. <h3>Results</h3> Patient mean age was 71.4 (SD 8.7) and 62% were male; carer mean age was 64.2 (SD 14.5) and 27% were male. 87% of patients lived with their carer and 84% of carers were spouses. There were no significant differences between patients and carers in total proportions reporting presence or assessment of severity, of any symptom. ICCs (Table 1) showed patient-carer agreement was only fair to moderate. Higher agreement was found for physical symptoms (constipation, diarrhoea) than psychological (anxiety, depression) or those with emotional valence (breathlessness, fatigue). Carers more frequently underestimated than overestimated symptoms, with the exception of physical symptoms. <h3>Conclusions</h3> Patient-carer agreement on symptom burden was generally low, and differed depending on symptom type. Poorer agreement for emotional symptoms and symptom underestimation by carers in this prospective population-based study may reflect patient concealment within dyads or the differences of a cohort recruited through primary care, compared to previous proxy studies in secondary care. These findings may also be due to longer disease trajectories in COPD, compared to previous studies in cancer, leading to carer compassion-fatigue or response-shift. Our findings have implications for the interpretation of proxy data in COPD, and suggest the need for carer education and support in symptom assessment.
High Risk Factors of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) for Leukemia.
Authors: Jia Chen, Feng Chen, Wu Depei, Aining Sun, Huiying Qiu, Zhengming Jin, Xiaowen Tang, Miao Miao, Chengcheng Fu, Guangsheng He
Journal: Blood (2009)
Mode of Action of the SDF-1/CXCL12 Inhibiting Spiegelmer® Nox-A12 and Its Impact On Chronic Lymphocytic Leukemia (CLL) Cell Motility and Chemosensitization
Authors: Dirk Zboralski, Julia Hoellenriegel, Christian Maasch, Anna Kruschinski, Jan A. Burger
Journal: Blood (2012)
MA06.02 Does Pathological Staging Following Neoadjuvant Therapy (ypTNM) Reflect the Reality?
Authors: Huseyin Melek, Hasan Kara, Adalet Demir, Mehmet Erol, Ahmet Sami Bayram, Akif Turna, Alper Toker, Cengiz Gebitekin
Journal: Journal of Thoracic Oncology (2017)
P3.03-029 EPP Followed by Hemithoracic IMRT - A Multicenter Study on Behalf of the Italian Association for Radiation Oncology Lung Cancer Study Group
Authors: Marco Trovo, Davide Franceschini, Gaia Piperno, Stefano Vagge, Vieri Scotti, Fiorenza De Rose, Anna Maria Ferrari, Michela Marcenaro, Marco Perna, Carla De Luca Cardillo, Emilio Minatel, Barbara Jereckzek, Marta Scorsetti, Lorenzo Livi, Renzo Corvo
Journal: Journal of Thoracic Oncology (2017)
Generalizability in Pragmatic Trials—Reply
Authors: Harold C. Sox, Roger J. Lewis
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S110 2-d segmental longitudinal strain rates correlate with prognostic indicators in idiopathic pulmonary arterial hypertension
Authors: TM Crowe, P Sonecki, A Mackenzie, G Jayasekera, AC Church, MK Johnson, AJ Peacock
Journal: Thorax (2016)

<h3>Background/objectives</h3> Speckle tracking echocardiography (STE) has added to the assessment of right ventricular function by providing off-line measurements of strain and strain rate. Worsening right ventricular function is associated with poorer outcomes in idiopathic pulmonary arterial hypertension (IPAH). Global right ventricular free wall (RVFW) longitudinal strain and strain rate have been reported as markers of prognosis. Differences in degree of regional RVFW deformation will affect the global RVFW analysis. We assessed whether RVFW segmental analysis using STE identified specific regional associations with proven prognostic markers. <h3>Method</h3> Using our database, we identified newly diagnosed cases of IPAH between January 2012 and May 2016. 25 cases had echocardiograms accessible for retrospective analysis. Using 2D-STE software (EchoPAC, GE Healthcare), we measured longitudinal strain and strain rate of the RVFW basal, mid and apical segments. Data on established prognostic markers, NT-proBNP, cardiac index (CI), WHO functional class (FC), six-minute walk distance (6MWD) and mixed venous saturations (SvO­2) were retrieved from the patient database. All data was anonymised for analysis. <h3>Results</h3> Basal peak systolic longitudinal strain rate (PSLSR) of the RVFW correlated very strongly with NT-proBNP (r = 0.82, p &lt; 0.001) and moderately with CI: (r = −0.53, p &lt; 0.007), WHO FC (r = 0.52, p &lt; 0.008) and SvO2 (r = −0.50, p &lt; 0.02). Basal late diastolic longitudinal strain rate (LDLSR) correlated strongly with SvO2 (r = 0.61, p &lt; 0.002), and moderately with NT-proBNP (r = −0.58, p &lt; 0.005), CI: (r = 0.57, p &lt; 0.004), 6MWD (r = 0.5, p &lt; 0.02), and WHO FC (r = −0.49, p &lt; 0.02). Mid PSLSR and LDLSR moderately correlated with SvO2 (r = −0.53 and 0.56), NT-proBNP (r = 0.5 and −0.5) and CI (r = −0.48 and 0.42), (all p &lt; 0.04). The apical segment showed no significant correlations. Peak systolic longitudinal strain demonstrated only one significant segmental correlation between the mid-segment and NT-proBNP (r = 0.44, p &lt; 0.05). <h3>Conclusion</h3> We have demonstrated that analysing RVFW longitudinal segments provides significant regional correlations with known prognostic markers in an IPAH population group. We have shown the significant advantage of longitudinal strain rate over strain in its strength and consistency of correlation with these markers. We have acknowledged basal and mid segments as significant regions of interest. This study shows that further exploration of right ventricular function in pulmonary hypertension by RVFW segmental analysis is indicated.
P1.05-003 Coexpression of CD8a and PD-L1 Frequently Observed in Resected NSCLC Tumors from Smokers
Authors: Aaron Lisberg, Robert Mckenna, Judy Dering, Hsiao-Wang Chen, Naeimeh Kamranpour, Dongmei Hou, Maria Velez, Robert Cameron, Jay Lee, Steven Dubinett, Dennis Slamon
Journal: Journal of Thoracic Oncology (2017)
P286 Cost-consequence of fluticasone furoate/vilanterol 100/25mcg for the management of copd in the spanish nhs: an analysis based on the copd salford lung study
Authors: A Huerta, I I Boucot, MT Driessen
Journal: Thorax (2016)

<h3>Introduction</h3> The Salford Lung Study (SLS) is an open label prospective randomised controlled effectiveness trial. The study was conducted in the UK between 2012 and 2015 in a population intended to be representative of everyday clinical practice and was intended to provide relevant evidence to support healthcare decisions in the management of Chronic Obstructive Pulmonary Disease (COPD) for clinicians, providers and policy makers. SLS investigated the effectiveness and safety of initiating treatment with fluticasone furoate/vilanterol (FF/VI) 100/25 mcg compared with continuing with usual COPD maintenance treatment (usual care). Compared with usual care, FF/VI statistically significantly reduced the annual rate of moderate and severe exacerbations by 8.41% (NNT = 7) in the intention to treat (ITT) population (&gt;1 exacerbation in the previous 3 y; n = 2799) and in patients with &gt;1 exacerbation in the previous 1 y; n = 2269). The objective of the present analysis is to estimate the economic impact of these results when applied to a Spanish setting. <h3>Methods</h3> An Excel based 1-year cost-consequence model was developed based on SLS results and from the Spanish National Health System (NHS) perspective. Mean annual rates of moderate/severe exacerbations were directly obtained from SLS (1.50 FF/VI and 1.64 usual care; ITT population). Serious adverse events were excluded from the analysis. Patients included in the analysis were diagnosed COPD patients &gt;40 years old, being treated with a maintenance treatment and having a history of exacerbations (N = 232,730, estimated from Spanish prevalence data). Costs were estimated from Spanish public sources and encompassed annual retail drug costs (FF/VI: 627.26 €, usual care: 782.24 €) and COPD exacerbation management costs (344€: moderate event; 903 €: severe event).It was assumed that within one year the use of FF/VI would increase from 3% to 10%. <h3>Results</h3> Substituting usual care with FF/VI is likely to be associated with reduced COPD medication and exacerbation management costs. Total annual savings of 3,236,647 € were obtained for this population. <h3>Conclusion</h3> The decreased rate of exacerbations with FF/VI compared with usual care observed in SLS trial could be transferable, translating into potential healthcare savings for the Spanish NHS. SLS results may support informed healthcare decisions across different settings.
P3.02c-027 Phase I and PK Study of the Folate Receptor-Targeted Small Molecule Drug Conjugate (SMDC) EC1456 in Advanced Cancer: Lung Cancer Subset
Authors: Martin Edelman, Jasgit Sachdev, Wael Harb, Allison Armour, Ding Wang, Linda Garland
Journal: Journal of Thoracic Oncology (2017)
P2-246: Phase II randomized study of vinorelbine alone or plus cisplatin against Chemo-naïve Inoperable Non-small Cell Lung Cancer in the Elderly
Authors: Yuh-Min Chen, Jen-Fu Shih, Reury-Perng Perng, Chun-Ming Tsai, Jacqueline Whang-Peng
Journal: Journal of Thoracic Oncology (2007)
Association Between Imatinib (IM) Transporters and Metabolizing Enzymes Genotype and Response in Newly Diagnosed Chronic Myeloid Leukemia (CML) Patients (Pts) Is Influenced by Ethnicity.
Authors: Simona Soverini, Sabrina Angelini, Eleonora Turrini, Fabrizio Pane, Fabrizio Quarantelli, Timothy P. Hughes, Deborah L White, Dong Wook Kim, Harriet Goh, Jerald Radich, Lan Beppu, Giuseppe Saglio, Daniela Cilloni, Carolina Terragna, Sandra Durante, Ilaria Iacobucci, Giovanni Perini, Patrizia Hrelia, Giorgio Cantelli Forti, Thea Kalebic, Matt Barnett, Mark Thornquist, Michele Baccarani, Giovanni Martinelli
Journal: Blood (2009)
Primary racemose haemangioma of the right bronchial artery with thrombus and slow meandering blood flow
Authors: Kazushi Fujimoto, Hajime Kasai, Toshihiko Sugiura, Nobuhiro Tanabe, Koichiro Tatsumi
Journal: Thorax (2017)

A 48-year-old man was admitted to our hospital because of an abnormal lung shadow detected on health check-up. He had no history of lung disease. Chest X-ray showed a nodule overlapping the pulmonary artery at the right hilar area; there was no other abnormality (figure 1A). Contrast-enhanced CT of the chest showed hyperplasia of a right racemose haemangioma of a bronchial artery (RHBA), with an area of low density that was suspected as thrombus or malignant tumour (figures 1B, C). Bronchial arteriography showed a pattern that was similar to the beans of a pagoda tree (an herbal medicine) and revealed a blood flow that was disproportionally slow to the artery branch and was meandering in the right RHBA. In addition, there was a relatively small …
GEP Analyses of Bone Marrow CD34+/Lin- Cells of Chronic Phase CML Patients at Diagnosis Identified Different Sets of Genes Associated to the Molecular Response after 3 and 6 Months of First-Line Nilotinib Treatment
Authors: Alessandra Trojani, Ester Pungolino, Milena Lodola, Barbara Di Camillo, Mariella D'Adda, Alessandra Perego, Mauro Turrini, Chiara Elena, Alessandra Iurlo, Cristina Buccelli, Simona Malato, Francesco Spina, Maria Luisa Latargia, Francesco Lanza, Sergio Pauli, Michela Anghilieri, Maria Cristina Carraro, Enrica Morra, Roberto Cairoli
Journal: Blood (2015)
Serum Cytokine Levels Predict Time to Progression after Rituximab as Initial Therapy in Patients with Follicular Grade 1 Non-Hodgkin Lymphoma.
Authors: Stephen M. Ansell, Anne J. Novak, Steven Ziesmer, Betsy LaPlant, James R. Cerhan, Zhi-Zhang Yang, Stacey R. Dillon, Thomas E. Witzig
Journal: Blood (2007)
OA05.02 Anti-Tumor Immunity is a Key Determinant of SCLC Survivorship
Authors: Farhad Kosari, Simone Terra, Aqsa Nasir, Prasuna Muppa, Marie Christine Aubry, Joanne Yi, Nafiseh Janaki, Aaron Mansfield, Mariza De Andrade, Ping Yang, George Vasmatzis, Virginia Van Keulen, Tobias Peikert
Journal: Journal of Thoracic Oncology (2017)
Cyclooxygenase-2 (COX-2) Is Frequently Expressed in Multiple Myeloma (MM) and Is Associated with Poor Outcome.
Authors: Marco Ladetto, Sonia Vallet, Andreas Trojan, Maria Dell’Aquila, Luigia Monitillo, Loredana Santo, Alessandra Bertola, Patrizia Falco, Federica Cavallo, Daniela Drandi, Irene Ricca, Gloria Pagliano, Monica Astolfi, Alberto Rocci, Beata Bode, Antonio Palumbo, Corrado Tarella, Paola Omedé, Mario Boccadoro
Journal: Blood (2004)
Two-Step Functional Innovation of the Stem-Cell Factors WUS/WOX5 during Plant Evolution
Authors: Yuzhou Zhang, Yue Jiao, Hengwu Jiao, Huabin Zhao, Yu-Xian Zhu
Journal: Molecular Biology and Evolution (2016)

WUS and WOX5, which are expressed, respectively, in the organizing center (OC) and the quiescent center (QC), are essential for shoot/root apical stem-cell maintenance in flowering plants. However, little is known about how these stem-cell factors evolved their functions in flowering plants. Here, we show that the WUS/WOX5 proteins acquired two distinct capabilities by a two-step functional innovation process in the course of plant evolution. The first-step is the apical stem-cell maintenance activity of WUS/WOX5, which originated in the common ancestor of ferns and seed plants, as evidenced by the interspecies complementation experiments, showing that ectopic expression of fern Ceratopteris richardii WUS-like (CrWUL) surrounding OC/QC, or exclusive OC-/QC-expressed gymnosperms/angiosperms WUS/WOX5 in Arabidopsis wus-1 and wox5-1 mutants, could rescue their phenotypes. The second-step is the intercellular mobility that emerged in the common ancestor of seed plants after divergence from the ferns. Evidence for this includes confocal imaging of GFP fusion proteins, showing that WUS/WOX5 from seed plants, rather than from the fern CrWUL, can migrate into cells adjacent to the OC/QC. Evolutionary analysis showed that the WUS-like gene was duplicated into two copies prior to the divergence of gymnosperms/angiosperms. Then the two gene copies (WUS and WOX5) have undergone similar levels of purifying selection, which is consistent with their conserved functions in angiosperm shoot/root stem-cell maintenance and floral organ formation. Our results highlight the critical roles and the essential prerequisites that the two-step functional innovation of these genes performs and represents in the origin of flowering plants.
P3.05-013 Development of the Kentucky LEADS Collaborative Lung Cancer Survivorship Care Program
Authors: Jamie Studts, Barbara Head, Michael Andrykowski, Jessica Burris, Tara Schapmire, Maureen Rigney, Amy Christian, Courtney Blair, Allyson Yates, Robin Vanderpool, Angela Criswell, Cynthia Robinson, Susanne Arnold
Journal: Journal of Thoracic Oncology (2017)
OA22.07 Correlation of CT Scan Based Tumor Volume Measurement to Actual Resected Tumor Volume - A New T-Factor?
Authors: Olivia Lauk, Martina Friess, Thi Dan Linh Nguyen-Kim, Thomas Frauenfelder, Sven Hillinger, Burkhardt Seifert, Ilhan Inci, Walter Weder, Isabelle Opitz
Journal: Journal of Thoracic Oncology (2017)
P24 Short term outcome of patients with acute pulmonary embolism and high lactate at a district general hospital
Authors: JB Adizie, ZD Momoh, B Soliman, A Macduff
Journal: Thorax (2016)

<h3>Introduction</h3> The risk stratification of haemodynamically stable patients presenting with pulmonary embolism (PE) is currently focussed on evidence of right ventricular (RV) dysfunction and myocardial necrosis (elevated Troponin). However these single markers have insufficient evidence to definitively guide treatment decision making. Plasma lactate has been shown to be potentially useful in identifying normotensive PE patients at high risk of PE related adverse events. The aim of this retrospective cross sectional study is to assess the role of serum lactate in the risk assessment of patients presenting with acute PE in a “real world” setting. <h3>Methods</h3> We reviewed the cases of all patients with a radiologically confirmed PE on CTPA from Royal Wolverhampton Hospital between June 2014 and June 2015. The primary outcome was PE related complications within 7 days of diagnosis. This comprised of shock (systolic blood pressure &lt;90 mmHg or pressure drop of ≥40 mmHg for ≥15 min), RV dysfunction, or need for cardiopulmonary resuscitation/mechanical ventilation. <h3>Results</h3> 172 patients were diagnosed with acute PE during this time. 169 cases were analysed (insufficient information recorded in 3). Serum lactate was recorded in 92 (54.4%). Out of the 92 patients, 38 (41.3%) had a PE related complication with a higher average lactate (2.40 mmol/L) than the 54 (58.7%) who did not (lactate of 1.73 mmol/L) (p &lt; 0.018 using the unpaired t test). PE related complications occurred in 33 (38.8%) of the 85 normotensive patients that had a lactate recorded. These patients also had a higher average lactate (2.24 mmol/L) than the 52 (61.2%) patients without complications (lactate 1.72 mmol/L) (p &lt; 0.05). The positive predictive value of lactate as a single marker for a PE related complication is 53.1%. However the combination of a lactate ≥2, evidence of RV dysfunction and positive Troponin had a positive predictive value of 100%. <h3>Conclusions</h3> This study adds to the evidence that a high serum lactate used in combination with a positive troponin and RV dysfunction can be a useful predictor of early adverse PE related events and may aid treatment decision making.
MA11.10 Prospective Study of Genome-Wide Strexome and Transcriptome Profiling in Patients with Small Cell Lung Cancer Progressing after 1st Line Therapy
Authors: Glen Weiss, Ashish Sangal, Heather Barilla, Sara Byron, Jeff Kiefer, Jessica Aldrich, Timothy Whitsett, John Carpten, David Craig
Journal: Journal of Thoracic Oncology (2017)