tbuckley/cabot-search huggingface dataset:
Rheumatoid Pericarditis
Authors: M. Wilkinson
Journal: BMJ (1962)

BJoAL 1723 -~~~~~~~~~~~~~~~~~~~~~~~~MCLJUA the patient with an underlying bronchial carcinoma, and, we would suggest, was probably a reflection of the underlying condition.The impressive increase of the y-globulins in these patients sets several problems.Is this increase the cause or the direct or indirect consequence of the polymyositis ?Is it that the increased y-globulin reflects a reaction of the organism against a pathogenic agent, or are there autoantibodies ?It would be of interest to know if any immunological reaction could be elicited between this abnormally increased y-globulin and products prepared from fresh surgical material such as an amputation.This, together with more extended studies on this subject, we propose to pursue.Summary The essential and striking electrophoretic changes in six patients with proved polymyositis were a markedly elevated y-globulin fraction followed by a decreased albumin; such a pattern, while not of course specific for this condition, would, we feel, be highly suggestive of polymyositis in a patient with muscle disease.The a,-globulin fraction was raised only in the one patient who had both dermatomyositis and an under- lying bronchial neoplasm.In the other two patients with skin involvement it remained at the upper limit of normal.The E.S.R. was strikingly raised only in the patient with the underlying neoplasm-in the remaining two cases with skin involvement it was normal in the one and slightly raised in the other.In the remaining three patients with polymyositis alone it was consistently normal with a single isolated exception, when the fall was only 18 mm. in one hour (Westergren).The glycoproteins were estimated in two patients, revealing an increased y-glycoprotein fraction in the one with polymyositis alone and showing a tissue- destruction pattern in the patient with an underlying bronchial neoplasm.We would like to thank Dr. W. H. McMenemey for his advice and encouragement and the various members of the consultant staff of Maida Vale Hospital for allowing us access to their patients.
Efficacy and Safety of Nilotinib in First Line Therapy in a Real Life Cohort of Chronic Myeloid Leukemia Patients
Authors: Luigia Luciano, Mario Annunziata, Maria Rosaria Esposito, Palmieri Francesco, Maria Iovine, Paolo Danise, Simona Pagliuca, Giovanna Giagnuolo, Antonello Sica, Roberto Vallone, Marilena Spiezia, Fabrizio Pane
Journal: Blood (2014)
Biochemical and Ultrastructural Study of Leu M1 Antigen in Reed-Sternberg Cells: Comparison With Granulocytes and Interdigitating Reticulum Cells
Authors: S M Hsu, L C Huang, P L Hsu, Z H Ge, Y S Ho, F Cuttita, J Mulshine
Journal: JNCI Journal of the National Cancer Institute (1986)

A group of monoclonal antibodies was shown to react with glycoconjugates containing a sugar sequence--lacto-N-fucopentaose III (LNF-III)--in granulocytes and in some normal nonlymphoid cells. The antibodies including anti-Leu M1, anti-My-1, WGHS 29-1, 534F-8, and 538F-12 of the immunoglobulin M-type were used to study the biochemical properties of LNF-III antigens in granulocytes, interdigitating reticulum cells, and neoplastic cells of Hodgkin's disease. In contrast to the presence of an abundant LNF-III glycolipid in granulocytes, the Hodgkin's neoplastic cells had no LNF-III glycolipid or contained only minimal amounts; however, both LNF-III glycoconjugates isolated from Hodgkin's neoplastic cells and interdigitating reticulum cells appeared to be a similar, if not an identical, 150,000-molecular-weight glycoprotein. The neoplastic cells in Hodgkin's disease appeared to show a biochemical property more closely related to interdigitating reticulum cells than any other cells in the monocyte-granulocyte-histiocyte system.
US senators urge FDA to take action over wasted cancer drugs
Authors: Michael McCarthy
Journal: BMJ (2016)

US senators are calling for federal officials to scrutinize the drug industry’s marketing of expensive cancer drugs in vials containing more of the drug than is often needed, a practice that leads to hundreds of millions of dollars worth of drugs being thrown away every year.

In a letter to the Department of Health and Human Services inspector general, Daniel Levinson, on 20 May, Democrat senators Dick Durbin of Illinois, Amy Klobuchar of Minnesota, Jeanne Shaheen of New Hampshire, and Barbara Mikulski of Maryland called for the department to identify drugs that were available in different vial sizes in other countries but were not …
Abstract B19: The histone demethylase KDM3A in Ewing sarcoma metastasis
Authors: Marybeth Sechler, Janet Parrish, Paul Jedlicka
Journal: Cancer Research (2016)

Abstract This study aims to explore the roles and mechanisms of new candidates for therapeutic targeting in Ewing Sarcoma. Ewing Sarcoma is an aggressive pediatric malignancy of the bone and soft tissue, driven by EWS/Ets oncogenic fusions and characterized by high propensity for metastasis and poor clinical outcomes. We have identified the histone demethylase KDM3A as a novel tumor and metastasis promoter downstream of EWS/Fli1, the most common driver in this disease. Moreover, we have identified the cell surface protein, Melanoma Cell Adhesion Molecule (MCAM), as a potential important mediator of KDM3A action. Our data show that both KDM3A and MCAM depletion can inhibit metastatic phenotypes. Additionally we explore the regulation of MCAM, showing that KDM3A may upregulate MCAM expression both through a direct as well as an indirect mechanism via the Ets1 transcription factor. Since both KDM3A and MCAM are pharmacologically targetable, understanding of this pathway could provide at least two new therapeutic targets in Ewing Sarcoma, and, importantly alternatives to drugging of EWS/Ets fusions, which to date has proven very difficult. Citation Format: Marybeth Sechler, Janet Parrish, Paul Jedlicka. The histone demethylase KDM3A in Ewing sarcoma metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B19.
Comparison of intramedullary myeloma and corresponding extramedullary soft tissue plasmacytomas using genetic mutational panel analyses
Authors: S J de Haart, S M Willems, T Mutis, M J Koudijs, M T van Blokland, H M Lokhorst, R A de Weger, M C Minnema
Journal: Blood Cancer Journal (2016)

Comparison of intramedullary myeloma and corresponding extramedullary soft tissue plasmacytomas using genetic mutational panel analyses
Abstract A21: MiR-106a and miR-106b affect growth and metastasis of lung adenocarcinoma
Authors: Katey SS Enfield, David A. Rowbotham, Alice Holly, Christine Anderson, Kevin W. Ng, Brenda de Carvalho Minatel, Graham Dellaire, Chiara Pastrello, Igor Jurisica, Calum MacAulay, Stephen Lam, Wan L. Lam
Journal: Cancer Research (2016)

Abstract Introduction: MiR-106a and miR-106b are paralogs of the oncogenic miR-17~92, and have been associated with poor outcome and metastasis in several solid tumors. Their role in lung cancer is relatively unexplored. We characterized the expression of miR-106a and miR-106b in a clinical cohort of lung adenocarcinoma (AC) tumors and assessed their ability to regulate growth and metastasis in cell models. Methods: MicroRNA (miRNA) expression was deduced from small RNA sequencing data derived from clinical lung AC specimens (60 localized, 27 with lymph node invasion) and paired non-malignant tissues. MiR-106a and miR-106b overexpression vectors and controls were stably transfected into immortalized non-malignant Human Bronchial Epithelial Cells (HBECs) and stage I AC cell lines with epithelial expression patterns by lentiviral delivery. Migration and invasion was assessed by Boyden chamber assay, while cell proliferation was assessed by BrdU incorporation assay. Expression of epithelial-to-mesenchymal transition (EMT) markers and other proteins of interest were assessed by Western Blot. Clinical associations in an external cohort were derived using publically available TCGA data. Results: MiR-106a and miR-106b were significantly overexpressed in lung AC with lymph node invasion. Overexpression of miR-106a and miR-106b significantly increased proliferation of lung AC cell lines, and was associated with decreased levels of predicted target, p21. AC cell lines displayed a marked increase in metastatic phenotypes in vitro, and were associated with increased mesenchymal and decreased epithelial markers, characteristic of EMT. Importantly, tumors with high expression of both miR-106a and miR-106b and mesenchymal marker vimentin had significantly poorer outcome. Conclusions: MiR-106a and miR-106b are overexpressed in metastatic lung AC. Lung AC cell models indicate these miRNAs are metastatic agonists, affecting the metastatic potential of cells at least in part via induction of EMT. A deeper characterization of this observation may reveal therapeutic intervention points, or, with the development of miRNA therapeutics, miR-106a/b may be promising targets to prevent or treat metastatic disease. Citation Format: Katey SS Enfield, David A. Rowbotham, Alice Holly, Christine Anderson, Kevin W. Ng, Brenda de Carvalho Minatel, Graham Dellaire, Chiara Pastrello, Igor Jurisica, Calum MacAulay, Stephen Lam, Wan L. Lam. MiR-106a and miR-106b affect growth and metastasis of lung adenocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr A21.
DSM-III-R personality disorders in patients with eating disorders
Authors: A F Gartner, R N Marcus, K Halmi, A W Loranger
Journal: American Journal of Psychiatry (1989)

The authors conducted a systematic examination of DSM-III-R personality disorders among 35 patients with eating disorders. Fifty-seven percent of the patients met the criteria for at least one axis II diagnosis; borderline, self-defeating, and avoidant were the most frequently assigned personality disorders. Forty percent of the patients were given two or more diagnoses, and 17% of the patients met criteria for five to seven diagnoses. No differences were found between patients with anorexia nervosa, anorexia and bulimia nervosa, and bulimia nervosa in the distribution of diagnoses or the frequency with which individual criteria (traits) were assigned.
The pruritus- and TH2-associated cytokine IL-31 promotes growth of sensory nerves
Authors: Micha Feld, Richard Garcia, Jörg Buddenkotte, Shintaro Katayama, Katherine Lewis, Gareth Muirhead, Peter Hevezi, Kristin Plesser, Holger Schrumpf, Kaarel Krjutskov, Olga Sergeeva, Hans Werner Müller, Sophia Tsoka, Juha Kere, Stacey R. Dillon, Martin Steinhoff, Bernhard Homey
Journal: Journal of Allergy and Clinical Immunology (2016)
Case 12-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Stephen W. Parker, Raymond A. Sobel
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 72-year-old man was admitted to the hospital for evaluation of "chronic meningitis."The patient was in a stable state of health until one year earlier, when he began to experience malaise, fatigue, and weight loss of an unknown amount. Six months before admission increasing lethargy and fatigue developed, and he noticed rapid loss of hearing in the right ear, with vertigo and right tinnitus. A friend observed ptosis of the left upper eyelid, followed by a left proptosis that gradually worsened. A left-sided nasal discharge developed and was treated with an antibiotic. Three months before entry . . .
Abstract IA27: Retooling CRISPR to turn genes on and off
Authors: Luke A. Gilbert, Max A. Horlbeck, Jacqueline Villalta, Shao Hao, Jason E. Gestwicki, Jonathan S. Weissman
Journal: Cancer Research (2016)

Abstract CRISPR (clustered regularly interspaced short palindromic repeats) is an adaptive genome defense system in bacteria and archaea. CRISPR has been widely repurposed as an RNA-guided genome editing method. We have shown that the endonuclease domains of the Cas9 protein can be mutated to create a programmable RNA-guided DNA-binding protein. In human cells, we have shown we can control transcription of endogenous coding and non-coding genes over a wide range (up to 1000 fold) by using dCas9 chimeras to deliver protein domains that either repress (CRISPRi) or activate (CRISPRa) transcription. These experiments provide proof of principle that we can use dCas9 as an RNA-guided DNA binding platform to deliver in theory any protein to a specific genomic location, which may be useful for studying transcription, epigenetic regulation, DNA replication and DNA repair. We have developed a genome-scale CRISPRi/a functional genomics platform for loss- and gain-of-function screening in human cells. We have demonstrated that our CRISPRi/a screening platform can robustly identify pathways and proteins required for cancer cell growth and survival. Gain-of-function CRISPRa screens promise to reveal a layer of genetic information missing from previous efforts. We have shown in a cell growth screen that CRISPRa reveals latent tumor suppressors and transcription factors that regulate cancer cell state in chronic myeloid leukemia cells. In proof of principle, we have also used CRISPRi/a screens to determine the mechanism of cellular uptake, trafficking, retro-translocation, and toxicity for a chimeric bacterial toxin. These experiments establish CRISPRi and CRISPRa as powerful tools that provide rich and complementary information for mapping complex pathways. Recently, we have used our CRISPRi/a functional genomics platform to determine the genetics of cellular response to HSP70 inhibitors, which are a new class of anti-cancer drugs targeting a non-oncogene addiction. Together, our experiments demonstrate the utility of our CRISPRi/a functional genomics approach for studying principles of oncogene and non-oncogene addiction in cancer biology and cancer therapy. Citation Format: Luke A. Gilbert, Max A. Horlbeck, Jacqueline Villalta, Shao Hao, Jason E. Gestwicki, Jonathan S. Weissman. Retooling CRISPR to turn genes on and off. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr IA27.
In Utero Diagnosis of Hemoglobinopathies
Authors: John C. Hobbins, Maurice J. Mahoney
Journal: New England Journal of Medicine (1974)

IN recent years rapid progress has been made in the antenatal diagnosis of inherited disease. The obstetrician and clinical geneticist are now provided with information presenting new options to prospective parents faced with the risk of an abnormal child. This progress has resulted largely from the ability of the physician safely to obtain amniotic fluid and constituent cells from the early mid-trimester pregnancy. On the basis of studies performed on this material, sex, chromosomal abnormalities and certain inborn errors of metabolism in the fetus genetically at risk can be predicted.1 Unfortunately, amniotic fluid does not provide the information to diagnose . . .
Surgery for left ventricular aneurysm. Early survival with and without endocardial resection.
Authors: Stephenson Lw, Hargrove Wc rd, Ratcliffe Mb, Edmunds Lh
Journal: Circulation (1989)

In the past 3 years, 86 patients had left ventricular aneurysms resected or plicated. Sixty-eight had recurrent sustained ventricular tachycardia as the indication for surgery and had preoperative and intraoperative electrophysiologic mapping. There were 14 hospital deaths (16%). Eight preoperative potential risk factors for early hospital mortality were analyzed by multivariate analysis. Only acute myocardial infarction within 30 days before surgery correlated with hospital death at the p less than 0.05 level. History of previous heart surgery and advanced New York Heart Association functional class were important risk factors at the p less than 0.1 level. Hospital mortality was 17.6% for patients who had intraoperative mapping and endocardial resection and 11.1% for the others. Patients who had aneurysm repair for ventricular tachycardia had a significantly higher incidence of low cardiac output early after surgery (p less than 0.025).
National agency has “transformed” UK clinical research
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The United Kingdom’s position as a world leader in clinical research and development has been restored over the past decade thanks to the national body set up to enhance research, a new report claims.1

The review, published to mark the 10th anniversary of the National Institute for Health Research (NIHR), praised its achievements in funding and supporting “world leading” clinical and applied health and social care research, as well as research infrastructure in the NHS.

The institute provides £1bn (€1.29bn; $1.46bn) of funding each year to support research and the NHS research infrastructure, with various aims including faster translation of new treatments, technologies, and diagnostics to improve outcomes for health and care services.

To mark the institute’s …
TSH response to TRH in depression with and without panic attacks
Authors: G M Gillette, J C Garbutt, D E Quade
Journal: American Journal of Psychiatry (1989)

Low thyroid-stimulating hormone (TSH) response to thyrotropin-releasing hormone (TRH) has been repeatedly described in approximately 25% of patients with major depression. Panic disorder appears related to depression along several dimensions, including prevalence of low TSH response to TRH. The authors divided 46 patients with primary unipolar depression by gender and by presence or absence of concurrent panic attacks and compared their TRH test results with those of 106 normal control subjects, controlling for confounding variables. Depressed patients with panic had higher prevalence of low TSH response and significantly lower mean TSH response than depressed patients without panic. The latter were indistinguishable from normal control subjects.
Inherence-based views of social categories
Authors: Marjorie Rhodes
Journal: Behavioral and Brain Sciences (2014)

Abstract Children adopt an inherence-based view of some social categories, viewing certain social categories as reflecting the inherent features of their members. Thinking of social categories in these terms contributes to prejudice and intergroup conflict. Thus, understanding what leads children to apply inherence-based views to particular categories could provide new direction for efforts to reduce these negative social phenomena.
Hormone-Dependent Mammary Tumors in Strain GR/A Mice. I. Alternation Between Ductal and Tumorous Phases of Growth During Serial Transplantation2
Authors: Bruce D. Aidells, Charles W. Daniel
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Hormone-Dependent Mammary Tumors in Strain GR/A Mice. I. Alternation Between Ductal and Tumorous Phases of Growth During Serial Transplantation Get access Bruce D. Aidells, Bruce D. Aidells Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles W. Daniel Charles W. Daniel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 6, June 1974, Pages 1855–1863, https://doi.org/10.1093/jnci/52.6.1855 Published: 01 June 1974 Article history Received: 03 January 1974 Accepted: 01 March 1974 Published: 01 June 1974
Abstract 10804: Incidence and Prognostic Significance of Silent Versus Clinically Manifest Myocardial Infarction in the Atherosclerosis Risk in Communities (ARIC) Study
Authors: Zhu-ming Zhang, Pentti M Rautaharju, Ronald J Prineas, Carlos J Rodriguez, Laura Loehr, Wayne Rosamond, Dalane Kitzman, David Couper, Elsayed Z Soliman
Journal: Circulation (2015)

Background: Differences in the incidence and prognostic significance of silent myocardial infarction (SMI) vs. MI with clinical manifestations (CMI) are not well-established in racially diverse populations. Methods: We compared the incidence of SMI and CMI and their associations with coronary heart disease (CHD) death and death from all causes in 9,498 participants (mean age 54 years, 56.9% women, 20.3% African-American) from the Atherosclerosis Risk in Communities (ARIC) study who were free of cardiovascular disease at baseline visit (1987-89). Incident SMI was defined as ECG evidence of MI without documented CMI occurring after the baseline visit until visit 4 (1996-98). CHD and all-cause deaths were ascertained starting from ARIC visit 4 until 2010 (median follow up 12 years). Results: There were 386 (4.1%) incident CMIs and 317 (3.3%) SMIs. Both CMI and SMI were more common in men (6.8% and 4.3%, respectively) than in women (2.0% and 2.6%, respectively) p&lt;0.001. Although SMI rates were comparable in blacks and whites (3.8% vs.3.2%, respectively), CMI was higher in whites (4.4% vs. 2.8%, respectively), p=0.003. In multivariable adjusted Cox Proportional models, both SMI and CMI (compared to no MI) were associated with increased risk of CHD and all-cause deaths, but the risk was higher in the CMI group ( Table ). A significant interaction by sex was observed; SMI and CMI were associated with higher risk of CHD and all-cause deaths in women compared to men (interaction p-value= 0.014). No significant interactions by age or race were detected. Conclusions: SMI is as common as CMI, and both are associated with increased risk of CHD and all-cause mortality. Racial and sex differences in the distribution of SMI and CMI, as well as sex differences in the prognostic significance of SMI and CMI exist. These findings suggest that an ECG finding of MI in persons without a history of MI may warrant consideration in personalized CHD prevention risk management efforts particularly in women.
Septic Thrombophlebitis with Septicemia
Authors: R. W. Phillips, John D. Eyre
Journal: New England Journal of Medicine (1958)

ONE of the major present-day problems is the increased prevalence of hospital-acquired staphylococcal infection.1 2 3 Numerous studies attest to the widespread distribution of these organisms contaminating the environment of the hospital, its personnel and patients.4 , 5 Emphasis has been placed on the need for increased vigilance to protect patients from these organisms by improved technics of isolation of infected cases, increased cleanliness of personnel coming into contact with patients6 (especially ones with decreased resistance due to debilitating disease) and less haphazard use of potent antibiotics so that staphylococci do not become exposed to such drugs and develop resistance.7 We recently observed 3 . . .
BACTERIOLOGICAL DIAGNOSIS OF TUBERCULOSIS
Authors: J Grosset
Journal: BMJ (1938)

Ziehl-Neelsen or fluorescence microscopy, culture and drug sensitivity test onto Loewenstein-Jensen medium or with the more rapid radiometric BACTEC system are still the reference diagnostic tests for tuberculosis. However the slow growth of mycobacteria, the severity of the disease caused and the lack of a suitable sub-typing scheme for epidemiological studies have made tuberculosis a popular application for molecular techniques. The four major diagnostic areas molecular techniques have been applied for: rapid identification of cultured mycobacteria; sub-typing of strains by a DNA fingerprinting method in contact tracing; rapid detection of antimicrobial resistance by direct DNA sequencing of target site genes, single strand conformation polymorphism analysis (PCR-SSCP) or line probe assay (LIPA); detection of M. tuberculosis complex in clinical material.