tbuckley/cabot-search huggingface dataset:
Survival of patients in a phase I clinic: The M. D. Anderson Cancer Center experience
Authors: J. J. Wheler, A. M. Tsimberidou, D. S. Hong, T. L. Jackson, D. Y. Polk, S. Pilat, S. Liu, L. Feng, R. Kurzrock
Journal: Journal of Clinical Oncology (2008)

11066 Background: The survival of patients treated on Phase I clinical trials in oncology remains undefined. The objectives of this study were to determine the overall survival of patients seen in our Phase I clinic for enrollment on an investigational study, and to evaluate factors predicting survival. Methods: We retrospectively reviewed the medical records of consecutive patients who presented for consultation to the Phase I Program from 9/04 through 12/06. We assessed presenting characteristics, treatment and overall survival. Survival time was measured from the time of initial consultation until death or last follow-up. Kaplan-Meier method was used, and the log-rank test was employed to compare the difference in survival between different patient prognostic groups. Cox proportional hazard models were utilized for multivariate analysis. Results: Two hundred patients were identified. The median age was 58 years (range, 12 to 85 years), and 57% were men. ECOG performance status was 0 in 41.0%, 1 in 52.5% and 2 in 6.5%. The median number of prior therapies was 4. Overall, 182 patients were treated on at least one Phase I clinical trial. With a median follow-up of 21 months, 44 patients remain alive. The median overall survival was 8.8 months (95% CI: 7.4, 10.7). In univariate analysis, factors predicting shorter survival were primary tumor in the gastrointestinal tract, including pancreatic cancer (vs. others; p=0.0001), history of thrombosis (p=0.0003), liver metastasis (p=0.02), lactate dehydrogenase levels ≥ upper limit of normal (ULN) (618 U/L; p<0.0001), platelet counts > ULN (440 × 109/L; p=0.009), Ca-125 ≥ ULN (35 U/mL; p=0.005), AST ≥ ULN (46 IU/L; p<0.0001) and alkaline phosphatase ≥ ULN (126 IU/L; p<0.0001). In multivariate analysis, independent factors predicting shorter survival were history of thrombosis [hazard ratio (HR)=2.28; p=0.008], liver metastasis (HR=1.47; p=0.02), platelets ≥440 × 109/L (HR=1.65; p=0.02), and Ca-125 > 35 U/mL (HR=1.76; p=0.04). Conclusions: The median survival of patients seen in our program was 8.8 months. Preliminary analysis identified risk factors predictive of survival. These factors can be used to identify specific risk groups and to compare results among different Phase 1 clinical trials. No significant financial relationships to disclose.
Impact of the Intensity of Conditioning Therapy On the Outcomes of Patients Aged 40 to 60 Years with Acute Myeloid Leukemia/Myelodysplastic Syndrome Undergoing Allogeneic Hematopoietic Cell Transplantation.
Authors: Murtadha K. Al-Khabori, Mohamed El-Emary, Gordon Guyatt, Ahmed Galal, John Kuruvilla, Jeffrey H. Lipton, Hans A. Messner, Vikas Gupta
Journal: Blood (2009)
T-Cell and B-Cell Responses After Vaccination against Influenza Virus and Pneumococcus in Chronic Phase CML Patients Treated with Tyrosine Kinase Inhibitors.
Authors: Hugues de Lavallade, Melanie Hart, Ian H Gabriel, Peter Kelleher, Abdullah Alsuliman, Ahmad Khoder, Dragana Milojkovic, Letizia Foroni, Marco Bua, Jane F. Apperley, John M Goldman, David Marin, Katayoun Rezvani
Journal: Blood (2009)
Azacitidine with Oral Cytarabine and Etoposide Induces Immediate Hematological and Cytogenetic Response in Higher Risk Myelodysplastic Syndromes Even in Single Azacitidine Resistance
Authors: Akihito Matsuoka, Masaki Tanibuchi, Norimitsu Kadowaki, Teruhisa Taoka
Journal: Blood (2015)
Eosinophilic Bronchiolitis And Asthmatic Granulomatosis: A Case Report Showing A Spectrum Of Presentation
Authors: F. E. Arimura, B. C. P. Ferreira, M. B. Felisbino, R. A. Athanazio, S. Z. Rached, B. G. Baldi, E. C. T. D. Nascimento, T. Mauad, R. M. D. Carvalho-Pinto, M. Dolhnikoff, R. Stelmach, A. Cukier
Journal: American Journal of Respiratory and Critical Care Medicine (2015)
Adjunctive Azithromycin Prophylaxis for Cesarean Delivery
Authors: James R Greig, Lewis Jones
Journal: New England Journal of Medicine (2017)

BACKGROUND-The addition of azithromycin to standard regimens for antibiotic prophylaxis before cesarean delivery may further reduce the rate of postoperative infection.We evaluated the benefits and safety of azithromycin-based extended-spectrum prophylaxis in women undergoing nonelective cesarean section.METHODS-In this trial conducted at 14 centers in the United States, we studied 2013 women who had a singleton pregnancy with a gestation of 24 weeks or more and who were undergoing cesarean delivery during labor or after membrane rupture.We randomly assigned 1019 to receive 500 mg of intravenous azithromycin and 994 to receive placebo.All the women were also scheduled to receive standard antibiotic prophylaxis.The primary outcome was a composite of endometritis, wound infection, or other infection occurring within 6 weeks. RESULTS-The primary outcome occurred in 62 women (6.1%) who received azithromycin and in 119 (12.0%) who received placebo (relative risk, 0.51; 95% confidence interval [CI], 0.38 to 0.68; P<0.001).There were significant differences between the azithromycin group and the placebo group in rates of endometritis (3.8% vs. 6.1%,P = 0.02), wound infection (2.4% vs. 6.6%,P<0.001), and serious maternal adverse events (1.5% vs. 2.9%, P = 0.03).There was no significant between-group difference in a secondary neonatal composite outcome that included neonatal death and serious neonatal complications (14.3% vs. 13.6%,P = 0.63).
DA-EPOCH Chemotherapy Is Highly Effective in ALK-Positive and ALK-Negative ALCL: Results of a Prospective Study of PTCL Subtypes in Adults
Authors: Kieron Dunleavy, Margaret Shovlin, Stefania Pittaluga, Cliona Grant, Seth M. Steinberg, Elaine S. Jaffe, Wyndham H Wilson
Journal: Blood (2011)
Spi-1/PU.1 Accelerates Replication Fork Elongation through PP1a Phosphatase-Associated Dephosphorylation of CHK1 in Erythroleukemic Cells
Authors: Pauline Rimmelé, Jean-Hugues Guervilly, Filippo Rosselli, Françoise Moreau-Gachelin, Christel Guillouf
Journal: Blood (2014)
Peptide-Vaccine Treatment Associated with TKI Therapy in Patients with CML Is Able to Induce Immunologic, Cytogenetic and Molecular Responses: a Single Center Experience with Long-Term Follow up.
Authors: Elisabetta Abruzzese, Malgorzata Monika Trawinska, Angela Coletta, Serena Zaza, Roberta Giovagnorio, Giovanni Del Poeta, Micaela Ippoliti, Delfina Marzia, Paolo de Fabritiis, Francesco Lo Coco, Sergio Amadori, Monica Bocchia
Journal: Blood (2009)
Defects of Base Excision Repair Involving OGG1 Can Be Detected in a Subset of Patients with MDS and May Convey Propensity to Chromosomal Breaks.
Authors: Anna Jankowska, Lukasz Gondek, Zach Nearman, Hadrian Szpurka, Ramon Tiu, Mikkael A. Sekeres, Jaroslaw P. Maciejewski
Journal: Blood (2006)
The Importance of the Baby-Friendly Hospital Initiative
Authors: Lawrence M. Gartner, Ann Brownlee, Patricia T. MacEnroe
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Phosphorylation of Spleen Tyrosine Kinase (Syk) Appears to Be Related to the Blast Phase of Chronic Myeloid Leukemia
Authors: Céline Bourgne, Alexandre Janel, Jacques Chassagne, Chantal Rapatel, Olivier Tournilhac, Agnès Guerci, Frédérique Lioret, Aurélie Briançon, Juliette Berger, Mahchid Bamdad, Nathalie Boiret-Dupré, Marc G Berger
Journal: Blood (2012)
Successful Allogeneic HSCT in a Patient with Chronic Granulomatous Disease and McLeod Phenotype after Sensitization to Kx- and K- Antigens.
Authors: Manfred Hoenig, Ansgar Schulz, Catharina Schuetz, Joachim Freihorst, Ulrich Baumann, Willy A. Flegel, Klaus-Michael Debatin, Wilhelm Friedrich
Journal: Blood (2005)
Buparlisib and paclitaxel in patients with platinum-pretreated recurrent or metastatic squamous cell carcinoma of the head and neck (BERIL-1): a randomised, double-blind, placebo-controlled phase 2 trial
Authors: Denis Soulières, Sandrine Faivre, Ricard Mesía, Éva Remenár, Shau-Hsuan Li, Andrey Karpenko, Arunee Dechaphunkul, Sebastian Ochsenreither, Laura Anna Kiss, Jin-Ching Lin, Raj Nagarkar, László Tamás, Sung-Bae Kim, Jozsef Erfán, Anna Alyasova, Stefan Kasper, Carlo Barone, Sabine Turri, Arunava Chakravartty, Marie Chol, Paola Aimone, Samit Hirawat, Lisa Licitra
Journal: The Lancet Oncology (2017)
Dynamics and Characteristics of BCR-ABL1 Multiple Mutations in Tyrosine Kinase Inhibitor Resistant CML
Authors: Soo-Hyun Kim, Soo Young Choi, Sung-Eun Lee, Ju-Hee Bang, Ji-Young Byeun, Jin-Eok Park, Hye-Rim Jeon, Eun-Jung Jang, Saengsuree Jootar, Dong-Wook Kim
Journal: Blood (2012)
Disruption of Direct 3-Dimensional (3D) Telomere-TRF2 (Telomere Related Factor 2) Interaction Is a Hallmark of Primary Hodgkin (H) and Reed-Sternberg (RS) Cells
Authors: Hans Knecht, Nathalie Johnson, Tina Petrogiannis-Haliotis, Daniel Lichtensztejn, Sabine Mai
Journal: Blood (2015)
DIFFERENTIAL VASCULAR HEALING PATTERNS WITH RAPID ABSORPTION BIODEGRADABLE POLYMER SIROLIMUS-ELUTING STENTS VERSUS DURABLE POLYMER EVEROLIMUS-ELUTING STENTS
Authors: Tomohisa Tada, Robert Byrne, Rezarta Cuni, Lamin King, Michael Joner, Albert Schomig, Adnan Kastrati
Journal: Journal of the American College of Cardiology (2012)
The Importance of the Baby-Friendly Hospital Initiative
Authors: Marsha Walker
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Real-world persistence with antiretroviral therapy for HIV in the United Kingdom: A multicentre retrospective cohort study
Authors: Joseph M. Lewis, Colette Smith, Adele Torkington, Craig Davies, Shazaad Ahmad, Andrew Tomkins, Jonathan Shaw, Margaret Kingston, Ghadeer Muqbill, Philip Hay, Larissa Mulka, Deborah Williams, Laura Waters, Nataliya Brima, Neal Marshall, Margaret Johnson, Mas Chaponda, Mark Nelson
Journal: Journal of Infection (2017)

ObjectivesPersistence with an antiretroviral therapy (ART) regimen for HIV can be defined as the length of time a patient remains on therapy before stopping or switching. We aimed to describe ART persistence in treatment naïve patients starting therapy in the United Kingdom, and to describe differential persistence by treatment regimen.MethodsWe performed a retrospective cohort study at eight UK centres of ART-naïve adults commencing ART between 2012 and 2015. Aggregate data were extracted from local treatment databases. Time to discontinuation was compared for different third agents and NRTI backbones using incidence rates.Results1949 patients contributed data to the analysis. Rate of third agent change was 28 per 100 person-years of follow up [95% CI 26–31] and NRTI backbone change of 15 per 100 person-years of follow up [95% CI 14–17]). Rilpivirine, as co-formulated rilpivirine/tenofovir/emtricitabine had a significantly lower discontinuation rate than all other third agents and, excluding single tablet regimens, co-formulated tenofovir/emtricitabine had a significantly lower discontinuation rate than co-formulated abacavir/lamivudine. The reasons for discontinuation were not well recorded.ConclusionsTreatment discontinuation is not an uncommon event. Rilpivirine had a significantly lower discontinuation rate than other third agents and tenofovir/emtricitabine a lower rate than co-formulated abacavir/lamivudine.
Development of a Panel of 3,500 SNP Based Functional Genetic Variants Relevant to the Etiology and Outcome in Multiple Myeloma.
Authors: David C. Johnson, Suzanne M. Grindle, Christine Ramos, Faith Davies, David Gonzalez, Brian A. Walker, Brian G.M. Durie, Brian G. Van Ness, Gareth J. Morgan
Journal: Blood (2005)
Evaluation of Atypical Low Energy Fractures in Patients Affected by Multiple Myeloma Treated with Bispohosphonates
Authors: Samantha Pozzi, Raffaella Marcheselli, Alessia Bari, Eliana Valentina Liardo, Paola Bresciani, Maria Teresa Donini, Santo Neri, Luciano Masini, Giuseppe Caparrotti, Pellegrino Musto, Elisa Ferraris, Daniela Petro, Luigi Marcheselli, Antonio Palumbo, Stefano Sacchi
Journal: Blood (2011)
Regional Emphysema Score Predicting Overall Survival, Quality of Life, and Pulmonary Function Recovery in Early-Stage Lung Cancer Patients
Authors: Jie Dai, Ming Liu, Stephen J. Swensen, Shawn M. Stoddard, Jason A. Wampfler, Andrew H. Limper, Gening Jiang, Ping Yang
Journal: Journal of Thoracic Oncology (2017)
Clinical, biological, and pathological features predicting non-sentinel lymph node (NSLN) status in breast cancer (BC).
Authors: J. Furlanetto, E. Fiorio, G. P. Pollini, Z. Franchini, P. Pietrarota, Q. Piubello, F. Bonetti, R. Micciolo, E. Manfrin, G. L. Cetto, A. Molino
Journal: Journal of Clinical Oncology (2011)

10622 Background: Complete axillary lymph node dissection (ALND) is still the standard of care for breast cancer (BC) patients with sentinel node (SLN) metastases. The aim of this study was to identify the clinical, biological and pathological features that may predict NSLN status. Methods: The study involved 200 patients with a diagnosis of operable invasive BC and a positive SLN who underwent surgery with ALND at the University and Civic Hospitals of Verona between 2001 and 2008. The clinical features considered were age at the time of surgery and the symptomatic/asymptomatic presentation of disease, and the pathological and biological features were TNM stage, grading, histological type, the presence/absence of lymph vascular invasion, the presence/absence of multifocal disease, ER and PgR status, the Ki-67 proliferative index, HER2 overexpression, the number of SLNs analysed, the number of metastatic SLNs, the size of the SLN metastasis (macro, micro, isolated cancer cells), and type of surgery (conservative surgery or mastectomy). The data were statistically analysed using chi-squared test and multivariate logistic regression. Results: The variables predicting NSLN metastasis were an older age (p=0.008), symptomatic disease at diagnosis (p=0.007), size >15 mm (p=0.03), T >1 vs T1 (p=0.002), lower ER (p=0.04) and PgR levels (p=0.02), larger SLN metastasis (p=0.002), mastectomy vs conservative surgery (p=0.01). These variables were analysed using multivariate logistic regression, which showed that the probability of NSLN status increased with increasing age, symptomatic disease, and the increasing size of the SLN metastasis. Conclusions: The study findings demonstrate the existence of clinical, biological and pathological features that can predict NSLN status. Further studies are necessary, but they seem to identify a subgroup of patients at low risk of NSLN metastasis after showing a positive SLN who could avoid ALND.
RHAMM/CD168 Is a Novel Leukemia Associated Antigen with Prognostic Value for Patients with B-Cell Chronic Lymphocytic Leukemia.
Authors: Krzysztof Giannopoulos, Alexander Krober, Anna Dmoszynska, Jacek Rolinski, Hartmut Dohner, Stephan Stilgenbauer, Michael Schmitt
Journal: Blood (2006)
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance
Authors: Elisa Álvarez Hernández, Sabine Kahl, Anett Seelig, Paul Begovatz, Martin Irmler, Yuliya Kupriyanova, Bettina Nowotny, Peter Nowotny, Christian Herder, Cristina Barosa, Filipa Carvalho, Jan Rozman, Susanne Neschen, John G. Jones, Johannes Beckers, Martin Hrabě de Angelis, Michael Roden
Journal: Journal of Clinical Investigation (2017)

BACKGROUND. Dietary intake of saturated fat is a likely contributor to nonalcoholic fatty liver disease (NAFLD) and insulin resistance, but the mechanisms that initiate these abnormalities in humans remain unclear. We examined the effects of a single oral saturated fat load on insulin sensitivity, hepatic glucose metabolism, and lipid metabolism in humans. Similarly, initiating mechanisms were examined after an equivalent challenge in mice.
IgG trough levels and progression of pulmonary disease in pediatric and adult common variable immunodeficiency disorder patients
Authors: Willemijn J.M. Janssen, Firdaus Mohamed Hoesein, Annick A.J.M. Van de Ven, Jacobien Maarschalk, Florien van Royen, Pim A. de Jong, Elisabeth A.M. Sanders, Joris M. van Montfrans, Pauline M. Ellerbroek
Journal: Journal of Allergy and Clinical Immunology (2017)
High Frequency of 1p36.32 Deletion or Loss of Heterozygosity in Follicular Lymphoma (FL).
Authors: K.-John Cheung, Adele Telenius, Betty Lai, Nathalie Johnson, Thomas Relander, Christian Steidl, Agnes Baross, Hong Qian, Jacquie Schein, Marco Marra, Joseph M. Connors, Randy D. Gascoyne, Douglas E. Horsman
Journal: Blood (2007)
Updated guideline on the management of common bile duct stones (CBDS)
Authors: Earl Williams, Ian Beckingham, Ghassan El Sayed, Kurinchi Gurusamy, Richard Sturgess, George Webster, Tudor Young
Journal: Gut (2017)

Common bile duct stones (CBDS) are estimated to be present in 10–20% of individuals with symptomatic gallstones. They can result in a number of health problems, including pain, jaundice, infection and acute pancreatitis. A variety of imaging modalities can be employed to identify the condition, while management of confirmed cases of CBDS may involve endoscopic retrograde cholangiopancreatography, surgery and radiological methods of stone extraction. Clinicians are therefore confronted with a number of potentially valid options to diagnose and treat individuals with suspected CBDS. The British Society of Gastroenterology first published a guideline on the management of CBDS in 2008. Since then a number of developments in management have occurred along with further systematic reviews of the available evidence. The following recommendations reflect these changes and provide updated guidance to healthcare professionals who are involved in the care of adult patients with suspected or proven CBDS. It is not a protocol and the recommendations contained within should not replace individual clinical judgement.
Dual Epigenetic Control of CCAAT/Enhancer Binding Protein α (C/EBPα) Expression in Acute Myeloid Leukemia.
Authors: Bjoern Hackanson, Kristi L. Bennett, Romulo M. Brena, Jinmai Jiang, Katie Maharry, Susan P. Whitman, Thomas D. Schmittgen, Michael Luebbert, Guido Marcucci, Clara D. Bloomfield, Christoph Plass
Journal: Blood (2007)
Caspase Activated Rock-1 Allows Erythroblasts Enucleation Independently of Cytokine Signaling
Authors: Genevieve Courtois, Julie Vandekerckhove, Yunhua Chang, jean-Antoine Ribeil, Joelle Kersual, Najet Debili, William Vainchenker, Bruno R. Varet, Olivier Hermine
Journal: Blood (2008)
Complete Response to First-Line Bortezomib-Thalidomide-Dexamethasone Therapy in Multiple Myeloma Patients with t(4;14): Analysis of Gene Expression Profile.
Authors: Carolina Terragna, Sandra Durante, Daniel Remondini, Giovanni Martinelli, Francesca Patriarca, Maria Teresa Petrucci, Monica Galli, Francesco Di Raimondo, Claudia Crippa, Mario Boccadoro, Annalisa Astolfi, Nicoletta Testoni, Giulia Marzocchi, Daniele Derudas, Stelvio Ballanti, Francesco Pisani, Gioacchino Catania, Luca Castagna, Salvatore Palmieri, Catello Califano, Anna Baraldi, Mariella Grasso, Pellegrino Musto, Annamaria Brioli, Michele Baccarani, Michele Cavo
Journal: Blood (2009)
CARD11 as an Oncogene in Diffuse Large B Cell Lymphoma.
Authors: Georg Lenz, R. Eric Davis, Vu N. Ngo, Lloyd T. Lam, Thaddeus George, George W. Wright, Sandeep S. Dave, Hong Zhao, Weihong Xu, Andreas Rosenwald, Hans-Konrad Muller-Hermelink, Randy D. Gascoyne, Joseph M. Connors, Elias Campo, Elaine S. Jaffe, Jan Delabie, Erlend B. Smeland, Lisa Rimsza, Richard I. Fisher, Wing C. Chan, Louis M. Staudt
Journal: Blood (2007)
SETBP1 Mutations Drive Leukemic Transformation in ASXL1-Mutated MDS
Authors: Daichi Inoue, Hirotaka Matsui, Hsin-An Hou, Wen-Chien Chou, Akiko Nagamachi, Jiro Kitaura, Kimihito Cojin Kawabata, Katsuhiro Togami, Reina Nagase, Sayuri Horikawa, Makoto Saika, Jean-Baptiste Micol, Yasutaka Hayashi, Yuka Harada, Hironori Harada, Hwei-Fang Tien, Omar Abdel-Wahab, Toshio Kitamura
Journal: Blood (2014)
Identification of Biologically Distinct and Clinically Relevant Subentities in Patients with Acute Myeloid Leukemia and Normal Karyotypes by Use of Gene Expression Profiling.
Authors: Wolfgang Kern, Claudia Schoch, Alexander Kohlmann, Martin Dugas, Sylvia Merk, Wolfgang Hiddemann, Susanne Schnittger, Torsten Haferlach
Journal: Blood (2004)
The influence of proton pump inhibitors and other commonly used medication on the gut microbiota
Authors: Floris Imhann, Arnau Vich Vila, Marc Jan Bonder, Ailine G. Lopez Manosalva, Debby P.Y. Koonen, Jingyuan Fu, Cisca Wijmenga, Alexandra Zhernakova, Rinse K. Weersma
Journal: Gut Microbes (2017)

Proton pump inhibitors (PPIs), used to treat gastro-esophageal reflux and prevent gastric ulcers, are among the most widely used drugs in the world. The use of PPIs is associated with an increased risk of enteric infections. Since the gut microbiota can, depending on composition, increase or decrease the risk of enteric infections, we investigated the effect of PPI-use on the gut microbiota. We discovered profound differences in the gut microbiota of PPI users: 20% of their bacterial taxa were statistically significantly altered compared with those of non-users. Moreover, we found that it is not only PPIs, but also antibiotics, antidepressants, statins and other commonly used medication were associated with distinct gut microbiota signatures. As a consequence, commonly used medications could affect how the gut microbiota resist enteric infections, promote or ameliorate gut inflammation, or change the host's metabolism. More studies are clearly needed to understand the role of commonly used medication in altering the gut microbiota as well as the subsequent health consequences.