tbuckley/cabot-search huggingface dataset:
Response to Letter Regarding Article, “Association of Coffee Consumption With Total and Cause-Specific Mortality in 3 Large Prospective Cohorts”
Authors: Ming Ding, Ambika Satija, Shilpa N Bhupathiraju, Yang Hu, Qi Sun, Jiali Han, Esther Lopez-Garcia, Walter Willett, Rob M. van Dam, Frank B. Hu
Journal: Circulation (2016)
Assessment of Administrative Data to Identify Acute Myocardial Infarction in Electronic Health Records
Authors: Robert J. Mentz, L. Kristin Newby, Ben Neely, Joseph E. Lucas, Sean D. Pokorney, Meena P. Rao, Larry R. Jackson, Maria V. Grau-Sepulveda, Michelle M. Smerek, Pamela Barth, Charlotte L. Nelson, Michael J. Pencina, Bimal R. Shah
Journal: Journal of the American College of Cardiology (2016)
Virus of Avian Myeloblastosis. X. Photometric Microdetermination of Adenosinetriphosphatase Activity&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: G. S. Beaudreau, Caroline Becker
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Virus of Avian Myeloblastosis. X. Photometric Microdetermination of Adenosinetriphosphatase Activity Get access G. S. Beaudreau, G. S. Beaudreau Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar Caroline Becker Caroline Becker Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 2, February 1958, Pages 339–349, https://doi.org/10.1093/jnci/20.2.339 Published: 01 February 1958 Article history Received: 29 July 1957 Published: 01 February 1958
The current status of psychiatric education in alcoholism and drug abuse
Authors: M Galanter, E Kaufman, Z Taintor, C B Robinowitz, R E Meyer, J Halikas
Journal: American Journal of Psychiatry (1989)

The authors conducted a survey of psychiatric education in alcoholism and drug abuse in the United States. Ninety-seven percent of 106 undergraduate training programs and 91% of 169 residency programs offered curriculum units in this field. Most of these programs also provided supervised clinical care. Areas of reported faculty dissatisfaction included problems with attitude and interest of psychiatric faculty and with the amount of curriculum time allotted. The authors conclude that although the amount of curriculum time devoted to training in alcoholism and drug abuse is growing, further investment in developing faculty and fellowships is warranted to increase the quality of teaching commitment.
Abstract P5-04-20: TLE1 protein expression in HER2-positive and triple-negative breast cancer
Authors: HJ Lee, M-H Oh, J-H Lee, HD Cho, S-H Jang, HY Jung, K-J Kim
Journal: Cancer Research (2016)

Abstract Purpose Transducin-like enhancer protein 1 (TLE1) is a member of the Groucho (Gro)/TLE family of transcriptional co-repressors that regulate the transcriptional activity of a wide range of genes. TLE1 has been shown to be a specific and diagnostically useful immunohistochemical marker for synovial sarcoma. However, there have been few reports of the status of TLE1 in breast cancers. The purpose of this study was to clarify the nuclear expression of TLE1 in 511 Korean breast cancers by immunohistochemistry (IHC) and to correlate the findings to clinicopathologic variables including prognostic significance. Methods IHC was performed on tissue microarrays (TMAs) in 511 cases of breast cancer. Associations between the TLE1 expression and the clinicopathologic characteristics were retrospectively analyzed. Progression-free survival and disease-specific survival was assessed by the Kaplan–Meier method and Cox regression model. Results Of 511 cases of breast cancer, high expression of the TLE1 was detected in 63 (12.3%) cases. TLE1-high expression was strongly associated with HER2-positive breast cancer phenotype (p &amp;lt; 0.001) and triple-negative breast cancer phenotype (p &amp;lt; 0.001). Furthermore, high TLE1was significantly associated with high histologic grade (p &amp;lt; 0.001), node-negative (p =0.011), estrogen receptor negativity (p &amp;lt; 0.001), progesterone receptor negativity (p &amp;lt; 0.001), CK5/6 positivity (p &amp;lt; 0.001), epidermal growth factor receptor positivity (p &amp;lt; 0.001), high ki-67 proliferative index (p &amp;lt; 0.001) and high p53 expression (p &amp;lt; 0.001). Survival analysis demonstrated no significant association between TLE1 expression and disease progression and cancer-related death (p =0.112 and p =0.068, respectively). Conclusion Our results show that high TLE1expression is significantly associated with HER2-positive and triple-negative breast cancer. TLE1 may represent a potential therapeutic target for this aggressive disease, which warrants further investigation. Citation Format: Lee HJ, Oh M-H, Lee J-H, Cho HD, Jang S-H, Jung HY, Kim K-J. TLE1 protein expression in HER2-positive and triple-negative breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-04-20.
The dexamethasone suppression test as a monitor of clinical recovery
Authors: E D Peselow, N Baxter, R R Fieve, F Barouche
Journal: American Journal of Psychiatry (1987)

To evaluate the dexamethasone suppression test (DST) as an aid in monitoring clinical recovery, the authors evaluated 127 outpatients with major depression who received the DST during depression and after clinical recovery. Although DST response varied among the 73 patients who met the Research Diagnostic Criteria for definite endogenous depression, their mean postdexamethasone plasma cortisol level was significantly higher during depression than after recovery. However, the DST's utility in monitoring long-term outcome was not great, as there was a high chance of remaining stable for 6 months after recovery regardless of cortisol value during depression or after recovery.
Unrelated donors are associated with improved relapse‐free survival compared to related donors in patients with myelodysplastic syndrome undergoing reduced intensity allogeneic stem cell transplantation
Authors: Clinton Yam, Lisa Crisalli, Selina M. Luger, Alison W. Loren, Elizabeth O. Hexner, Noelle V. Frey, James K. Mangan, Amy Gao, Edward A. Stadtmauer, David L. Porter, Ran Reshef
Journal: American Journal of Hematology (2016)

Reduced intensity allogeneic stem cell transplantation (RI alloSCT) is a potentially curative treatment approach for patients with myelodysplastic syndrome (MDS). It is currently unclear if older related donors are better than younger unrelated donors for patients with MDS undergoing RI alloSCT. We retrospectively studied 53 consecutive MDS patients who underwent RI alloSCT between April 2007 and June 2014 and evaluated associations between donor type and outcomes with adjustment for significant covariates. 34 patients (median age: 64 years) and 19 patients (median age: 60 years) received allografts from unrelated and related donors, respectively. Unrelated donors were younger than related donors (median age: 32 vs. 60 years, P < 0.0001). There were no significant differences in baseline disease characteristics of patients receiving allografts from related or unrelated donors. Patients who received allografts from unrelated donors had a lower relapse risk (adjusted hazard ratio [aHR] = 0.35, P = 0.012) and improved relapse-free survival (aHR = 0.47, P = 0.018). HLA mismatched unrelated donors were associated with a higher risk of grade 2-4 acute graft versus host disease (GVHD) (HR = 4.64, P = 0.002) without an accompanying increase in the risk of non-relapse mortality (P = 0.56). Unrelated donors provided a higher mean CD8 cell dose (P = 0.014) and were associated with higher median donor T cell chimerism at day 60 (P = 0.003) and day 100 (P = 0.03). In conclusion, patients with MDS who received allografts from unrelated donors had a lower risk of relapse and improved relapse-free survival when compared to patients who received allografts from related donors. These findings should be confirmed in a prospective study. Am. J. Hematol. 91:883-887, 2016. © 2016 Wiley Periodicals, Inc.
Roseola Infantum
Authors: E. L. McQuitty
Journal: BMJ (1955)

HAEMOLYTIC ANAEMIA IN PREGNANCYEJotm 1005In this case the haemolytic process seems to be due to overactivity of the normal mechanisms for the removal of red cells from the blood stream.The nature of such mechanisms is at present obscure.It is known, however, that they are influenced by the sex hormones.Hyperhaemo- lysis has been demonstrated in normal women during the latter part of the menstrual cycle (Ashby, 1921 ; Berlin, 1951).These authors, while admitting the obscurity of the nature of this hyperhaemolysis, conclude that it is due to hormone influences; Berlin also believes that the spleen plays no part in its production, as he found it to persist after splenectomy.Presumably, during a normal pregnancy the hyperhaemolysis is inhibited, to prevent the increased concentration of sex hormones following gestation from causing a haemolytic anaemia.In our case the inhibitory mechanisms would appear to have failed. SummaryA case of symptomatic haemolytic anaemia associated with pregnancy is described.The haemolytic process occurred during a young woman's first two pregnancies and ceased spontaneously on both occasions during the puerperium.Neither circulating haemolysins nor atypical agglutinins were demonstrated.The mechanism of the hyperhaemolysis was obscure.We suggest that it may be related to that occurring during the pro: gestational phase of the normal menstrual cycle.We are indebted to Dr. J. F.
Antiplatelet Antibody
Authors: PHILIP L. CIMO
Journal: Annals of Internal Medicine (1975)

Comments and Correction1 November 1975Antiplatelet AntibodyPHILIP L. CIMO, M.D.PHILIP L. CIMO, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-83-5-738_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: In their recent paper (Ann Intern Med83:190-196, 1975) Lackner and Karpatkin reported that many patients with the "easy bruising" syndrome have abnormal platelet function, increased percentages of megathrombocytes, and an elevated prevalence of antiplatelet antibody. I agree that the easy bruising in these patients reflects a qualitative platelet defect, but I question whether the defect is the result of an autoimmune process. Most of the patients studied were women of child-bearing age and, unless the target platelets used for platelet antibody testing were autologous, the increased frequency of platelet antibody activity could be explained by the...References1. O'BRIENJAMIESON JS: A relationship between platelet volume and platelet number. Thromb Diath Haemorrh 31:363-365, 1974 MedlineGoogle Scholar2. VON BEHRENS W: Mediterranean macrothrombocytopenia. Blood 46:199-208, 1975 CrossrefMedlineGoogle Scholar3. MURPHY S: Hereditary thrombocytopenia. Clin Haematol 1:359-368, 1972 Google Scholar1. GARGAMOROSIKARPATKIN SES: Use of the megathrombocyte as an index of megakaryocyte number. N Engl J Med 284:11-17, 1971 CrossrefMedlineGoogle Scholar2. KARPATKINGARGSISKIND SSG: Autoimmune thrombocytopenic purpura and the compensated thrombocytolytic state. Am J Med 51:1-4, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Division of Hematology University of Texas Medical School Houston, Texas 77025 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 November 1975Volume 83, Issue 5Page: 738-738KeywordsAntiplatelet antibodiesPlatelets Issue Published: 1 November 1975 PDF DownloadLoading ...
Bone marrow metastasis presenting as bicytopenia originating from hepatocellular carcinoma
Authors: Young Mi Hong, Ki Tae Yoon, Mong Cho, Dae Hwan Kang, Hyung Wook Kim, Cheol Woong Choi, Su Bum Park, Jeong Heo, Hyun Young Woo, Won Lim, SM Bakhtiar UI Islam
Journal: Clinical and Molecular Hepatology (2016)

The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargement that was detected when examining his general weakness and weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated liver enzymes, normal prothrombin time percentage and high levels of tumor markers (α-fetoprotein and des-γ-carboxyprothrombin). Abdominal computed tomography showed multiple enhanced masses in the liver and multiple enlarged lymph nodes in the abdomen. A bone marrow biopsy revealed only a few normal hematopoietic cells and abundant tumor cells. Despite its rarity, bone marrow metastasis should always be suspected in HCC patients even if accompanied by cirrhosis. Keywords: Carcinoma; Hepatocellular; Bone marrow; Metastasis
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1978)

COMMITTEE ON MATERNAL WELFARERupture of the Cecum after Cesarean SectionA 36-year-old gravida 3, para 3 (one set of twins), was admitted at 32 weeks to a community hospital because of painless vaginal bleeding. Sent at once to a high-risk center for diagnostic ultrasound, she was returned to the original institution. The sonograms disclosed low placental implantation, a single fetus in breech presentation and biparietal diameter consistent with 28 weeks' gestation.Eleven days later, the patient bled heavily and was soon in labor. Prompt cesarean section under spinal anesthesia yielded a 1.36-kg baby in excellent condition who was transferred . . .
Marijuana use and psychiatric illness: a follow-up study
Authors: R A Weller, J A Halikas
Journal: American Journal of Psychiatry (1985)

In 1970, 100 regular marijuana users and 50 of their nonuser friends underwent a psychiatric evaluation. Of these, 97 users and all 50 nonusers were reinterviewed 6-7 years later. At follow-up, 60% of both groups had a psychiatric diagnosis. Antisocial personality was more prevalent in users; otherwise, there were no significant differences in diagnosis. Depression, alcohol abuse, and antisocial personality increased in users. However, these increases occurred in subjects who had reported problems in these areas in the initial interview but did not then meet diagnostic criteria. There was not a significant increase in the total number with a diagnosable illness.
Blind ratings of mother-infant interaction in home movies of prepsychotic and normal infants
Authors: H N Massie
Journal: American Journal of Psychiatry (1978)

Home movies of infants later diagnosed as having early childhood psychoses were compared with movies of normal control infants. A scale of attachment indicators measured mother-infant dyadic avoidance and reciprocity in the first 6 months of the infant's life. Three judges blind to diagnosis saw a general trend to dampened interaction for prepsychotic infants and their mothers. Prepsychotic and normal infants were not significantly different in touching and eye gaze behaviors, whereas mothers of prepsychotic infants exhibited less adequate eye gaze and touching than mothers of normal infants.
Personality and behavior patterns of heroin-dependent American servicemen in Thailand
Authors: G Kojak, J P Canby
Journal: American Journal of Psychiatry (1975)

The authors compared a groups of heroin-dependent American servicemen stationed in Thailand with a matched control groups of men not dependent on heroin. The data gathered regarding social history, attitudes, work record, previous drug use, personality, and intelligence show significant differences between the heroin-dependent men and the control group in four areas: intelligence, work record, number of years of schooling and number of drug used before using heroin. The data suggest that many of the heroin-dependent men had difficulties related to a distant or negative relationship to their fathers; however, in contrast to previous studies of heroin addicts, they do not confirm a relationship between heroin dependence and any particular personality pattern.
Medical students' evaluation of psychiatry: a cross-country comparison
Authors: J Yager, K Lamotte, A Nielsen, J S Eaton
Journal: American Journal of Psychiatry (1982)

The authors reviewed studies of attitudes toward psychiatry held by 368 medical students at the University of California, Los Angeles (UCLA), and 204 senior medical students from two schools in Washington, D.C. They found that the attitudes of all these students were remarkably similar: they viewed psychiatry as a worthwhile medical specialty but one of low prestige and low precision and thought that most psychiatric patients could be adequately managed by non-physicians. On the basis of their findings the authors offer recommendations for teaching basic psychiatric skills and for improving psychiatry's image and attractiveness.
Pretreatment source of income and response to methadone maintenance: a follow-up study
Authors: A T McLellan, J C Ball, L Rosen, C P O'Brien
Journal: American Journal of Psychiatry (1981)

The authors assessed the relationship between source of pretreatment income and response to treatment at 6-month follow-up in 165 male veterans admitted to a methadone maintenance treatment program. Subjects were grouped according to whether the majority of their pretreatment income was based on job earnings, public assistance, or criminal activity. Significant improvements in drug use, legal status, and psychological functioning were found in the employed group. The group supported by criminal activity showed the most significant and pervasive improvements, especially in the areas of drug use and family, legal, and employment problems. The group receiving public assistance showed no significant improvements on any of the 16 criterion measures, including drug use.
Abstract IA04: Functional genomics for discovery of pathogenic mechanisms of disease and novel therapies for hematologic malignancies
Authors: Jeffrey W. Tyner
Journal: Clinical Cancer Research (2016)

Abstract Our ability to quickly and cost-effectively decode cancer genomes and identify somatic mutations has been revolutionized by deep sequencing technologies. In some instances, the identification of these somatic driver mutations has resulted in implementation of more effective therapeutic strategies for patients. However, in many instances knowledge of somatic drivers has not resulted in new therapeutic strategies. In some cases, these driver mutations are gain-of-function and targeted drugs have not yet been developed, such that further drug development will bridge the translational gap between genomic knowledge and clinical translation. However, in many cases the somatic driver mutations are not directly targetable because the mutations result in loss-of-function of the mutated gene. In these cases, we face a critical knowledge gap between understanding of the identity of molecular drivers of disease and understanding of the dysregulated signaling pathways that result from these loss-of-function genetic events. It will be important to close this knowledge gap in order to better understand the targeted therapies that can be effective for all somatic driver events, such that all cancer patients can receive effective, individually tailored therapies. My lab has developed ex vivo, functional screening platforms that can be applied directly to primary specimens from patients with hematologic malignancies. These assays are based on panels of drugs and can deliver information about the specific drugs (or combinations of drugs) to which a patient's tumor cells are hypersensitive. Integration of these functional data with genomic information about each patient's tumor cells has allowed us to accelerate the process by which we discover actionable therapeutic strategies that correlate with tumor genotypes. In addition, these assays are completed in a clinically relevant time frame of three days, such that the data from these assays can be used to directly inform therapeutic strategies, even in the absence of genomic information. In this lecture, I will provide an overview of these functional screening platforms, I will illustrate strategies of data integration that have enabled rapid discovery and translation of new targeted therapy strategies, and I will discuss our experience to date with direct clinical implementation of findings from these functional screening data. Citation Format: Jeffrey W. Tyner. Functional genomics for discovery of pathogenic mechanisms of disease and novel therapies for hematologic malignancies. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr IA04.
FDG PET/CT Appearance of Radiation Nephritis
Authors: Hyung Jin Choi, Hunbo Shim, Hyewon Hyun, Victor H. Gerbaudo, Chun K. Kim
Journal: Clinical Nuclear Medicine (2015)

It is often challenging to assess renal activity on FDG-PET/CT due to intense physiological activity in the collecting system, thus any unusual intrarenal activity should be evaluated carefully. While increased bone tracer uptake in the irradiated region of the kidneys has been reported in the literature, altered biodistribution of FDG in irradiated renal tissue is not well described. We report a case of FDG PET/CT showing increased FDG activity in small portions of the kidneys that were previously irradiated.
Plasma Growth Hormone: Effect of Anxiety During Flooding in Vivo
Authors: George C. Curtis, Randolph Nesse, Martin Buxton, David Lippman
Journal: American Journal of Psychiatry (1979)

The treatment of phobias by rapid in vivo exposure to the feared situation was accompanied by an increase in plasma growth hormone levels on at least one of two occasions in 8 of 11 subjects. The average growth hormone response was greater on the second occasion, even though subjective anxiety was less. Plasma growth hormone was not elevated during the subjects' adaptation to the laboratory. Strong subjective and behavioral anxiety responses failed to elevate plasma growth hormone levels in some subjects. The probability of a growth hormone response was the same whether or not baseline levels were elevated prior to exposure.