tbuckley/cabot-search huggingface dataset:
THU0389 The Effects of Antihypertensive Drugs on Bone Mineral Density in Ovariectomized Mice
Authors: K. Y. Kang, Y. Kang, Y. S. Hong, J. H. Ju
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Antihypertensive drugs impact osteoporosis directly and indirectly by affecting bone metabolism. Because antihypertensive drugs are widely used for the treatment of hypertension, it is important to understand the effects of these drugs on bone density (1). <h3>Objectives</h3> The effects of several antihypertensive drugs on bone mineral density and micro-architectural changes in ovariectomized (OVX) mice were investigated. <h3>Methods</h3> Eight-week-old female C57/BL6 mice were used for this study. Three days after ovariectomy, mice were treated intraperitoneally with nifedipine (15 mg/kg b.w.), telmisartan (5 mg/kg b.w.), enalapril (20 mg/kg b.w.), propranolol (1 mg/kg b.w.) or hydrochlorothiazide (12.5 mg/kg b.w.) for 35 consecutive days. Uterine atrophy confirmed estrogen deficiency. Bone mineral density (BMD) and micro-architectural analyses were performed on tibial proximal ends by micro-computed tomography (micro-CT). <h3>Results</h3> When OVX mice with uterine atrophy were compared with mice without atrophy, BMD decreased (<i>p</i>&lt;0.001). There were significant differences in BMD loss between different antihypertensive drugs (<i>p</i>=0.005). By post hoc analysis, enalapril and propranolol increased BMD loss in mice with atrophied uteri compared with control mice. By contrast, thiazide increased BMD in mice with uterine atrophy compared with vehicle-treated mice (<i>p</i>=0.048). Thiazide (<i>p</i>=0.032) and telmisartan (<i>p</i>=0.05) reduced bone loss and bone fraction in mice with uterine atrophy compared with the control. BMD also correlated with bone volume and fraction, and trabecular number and thickness by micro-CT analysis. <h3>Conclusions</h3> Thiazide affects BMD in OVX mice positively. The reduction in bone loss by thiazide and telmisartan suggest that these drugs may benefit menopausal women with hypertension and osteoporosis. <h3>References</h3> Ott SM, LaCroix AZ, Scholes D, Ichikawa LE, Wu K 2008 Effects of three years of low-dose thiazides on mineral metabolism in healthy elderly persons. Osteoporos Int <b>19</b>(9)<b>:</b>1315-22. <h3>Disclosure of Interest</h3> None Declared
AB0548 Sapho syndrome and inflammatory bowel disease: systematic review.
Authors: J. E. Naves, M. Martínez-Morillo, E. Cabré, M. Mañosa, E. Domènech, B. Tejera Segura, D. Grados, S. Holgado, L. Mateo, A. Olivé
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The association of the SAPHO syndrome and inflammatory bowel disease (IBD) was first reported in 1992. To date, only case reports and short series have been published. <h3>Objectives</h3> To report three new cases and systematically review the literature on this association. <h3>Methods</h3> All patients with concomitant diagnosis of SAPHO syndrome and IBD were identified from the databases of the Rheumatology and Gastroenterology departments of our institution, which has a reference area of 800000 inhabitants. In addition, we systematically searched for published full articles in Medlars Online International Literature (MEDLINE) via PubMed. Relevant information of each positive match was collected and all authors were contacted for additional clinical data. <h3>Results</h3> Three patients sharing both SAPHO syndrome and IBD were identified among the 62 patients with SAPHO syndrome (4.8% of the SAPHO cohort) and among 1,309 patients with IBD (0.2% of the IBD cohort) from our hospital database. After a systematic review, others 36 cases with concomitant diagnosis of IBD and SAPHO syndrome or its variant chronic recurrent multifocal osteomyelitis (CRMO) were identified. There was a female predominance (64%) and an early age of onset of both diseases (24 years for SAPHO syndrome and 18 years for IBD). SAPHO diagnosis preceded IBD diagnosis in 55% of cases, being simultaneous or subsequent in the rest. A high proportion of patients presented Crohn’s disease (69%) with colonic involvement. The most frequent osteoarticular locations were peripheral joints (61%); anterior chest wall (56%), sacroiliac joint (20%), y spine (18%). Approximately 41% of cases developed typical SAPHO skin manifestations, being palmoplantar pustolosis the most common. The most common treatment for IBD of the subgroup of cases published after year 2000 were corticosteroids (68%), aminosalicylates (52%), immunossupresors (37%), anti-TNF (16%); and for SAPHO syndrome NAIDs (63%), corticosteroids (37%); aminosalicylates (31%), immunossupresors (21%), pamidronate (16%) y anti-TNF (16%). <h3>Conclusions</h3> SAPHO syndrome seems to precede IBD. It is more frequent in females and at early ages. Crohn’s disease is more associated to SAPHO than ulcerative colitis. Interestingly enough colic involvement is more frequent. Both diseases respond well to the same treatments but NAIDs should be avoided because their potential risk of triggering a flare of IBD. <h3>Disclosure of Interest</h3> None Declared
THU0478-HPR Health professionals &amp; rheumatoid arthritis care in resource poor settings
Authors: P. Shankpal
Journal: Annals of the Rheumatic Diseases (2013)

<b><i>Background:</i></b><i>Campylobacter jejuni</i> enteritis is the most common antecedent infection in Guillain–Barré syndrome (GBS). <i>C. jejuni</i>-related GBS is usually acute motor axonal neuropathy (AMAN), but previous reports described many cases of the demyelinating subtype of GBS (acute inflammatory demyelinating polyneuropathy [AIDP]) after <i>C. jejuni</i> infection. <b><i>Objective:</i></b> To investigate whether <i>C. jejuni</i> infection elicits AIDP. <b><i>Methods:</i></b> In 159 consecutive patients with GBS, antibodies against <i>C. jejuni</i> were measured using ELISA. Antecedent <i>C. jejuni</i> infection was determined by the strict criteria of positive <i>C. jejuni</i> serology and a history of a diarrheal illness within the previous 3 weeks. Electrodiagnostic studies were performed weekly for the first 4 weeks, and sequential findings were analyzed. <b><i>Results:</i></b> There was evidence of recent <i>C. jejuni</i> infection in 22 (14%) patients. By electrodiagnostic criteria, these patients were classified with AMAN (n = 16; 73%) or AIDP (n = 5; 23%) or as unclassified (n = 1) in the first studies. The five <i>C. jejuni</i>-positive patients with the AIDP pattern showed prolonged motor distal latencies in two or more nerves and had their rapid normalization within 2 weeks, eventually all showing the AMAN pattern. In contrast, patients with cytomegalovirus- or Epstein–Barr virus-related AIDP (n = 13) showed progressive increases in distal latencies in the 8 weeks after onset. <b><i>Conclusion:</i></b> Patients with <i>C. jejuni</i>-related Guillain–Barré syndrome can show transient slowing of nerve conduction, mimicking demyelination, but <i>C. jejuni</i> infection does not appear to elicit acute inflammatory demyelinating polyneuropathy.
755 DIAGNOSIS OF HEPATOCELLLAR CARCINOMA IN CIRRHOTIC PATIENTS USING SERUM RAMAN MICROSPECTROSCOPY
Authors: I. Taleb, G.D. Sockalingum, C. Gobinet, V. Untereiner, A. Heurgué, P. Ducoroy, P. Hillon, M. Manfait, G. Thiéfin
Journal: Journal of Hepatology (2012)
Chronic Vascular Graft Infection With Fistula to Bone Causing Vertebral Osteomyelitis, Imaged With F-18 FDG PET/CT
Authors: William Makis, Jerry Stern
Journal: Clinical Nuclear Medicine (2010)

Vascular grafts have an infection rate ranging from 1% to 3%. While early infections occur within 4 months after surgery and are associated with virulent organisms, late infections can occur after months to years of surgery and are often caused by low virulence organisms that survive in an adherent biofilm. Host defense recognition of bacterial biofilm can result in perigraft abscesses, aorto-enteric fistulas, and very rarely, fistulas into adjacent bone. We present a case of an 83-year-old man, who had an F-18 FDG PET/CT scan for workup of a solitary pulmonary nodule, and was incidentally diagnosed with chronic multifocal infection of an aorto-iliac vascular graft, with an infected fistula tract into adjacent bone causing chronic vertebral osteomyelitis, which was confirmed with a contrast-enhanced CT. The patient was asymptomatic and not a surgical candidate, and was treated conservatively with a course of antibiotics. This case highlights the utility of F-18 FDG PET/CT in the imaging of chronically infected vascular grafts and in identifying potentially lethal complications such as fistulas into adjacent structures.
Paget Disease of the Thumb
Authors: ZAKARIA I. ASSI, NICOLAAS I. BOHNEN, BARRY L. SHULKIN
Journal: Clinical Nuclear Medicine (1999)

A 69-year-old man who had an elevated prostate-specific antigen level and newly diagnosed biopsy-proved prostate cancer was referred for Tc-99m MDP bone scintigraphy for initial evaluation of skeletal metastases. He had no skeletal pain or deformities. The bone scintigram unexpectedly revealed pagetoid findings in the hips, femurs, left scapula, and the right thumb. Paget disease of the thumb is extremely rare but has characteristic findings on plain radiographs.
AB1043 Assessing osteoporosis risk in patients with rheumatoid arthritis – role of annual review clinic
Authors: U. Karjigi, V. Patel, R. Abernethy, J. Dawson, A. Clewes, J. Novak, A. Cox, J. Williams, T. O’Rourke
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Osteoporosis is a major cause of morbidity in patients with RA. It leads to fragility fractures frequently associated with disability, mortality and major financial and social impact [1]. There is no clear guidance regarding when to screen for Osteoporosis in these group of patients who are at high risk compared to general population. In our institute we assess the risk using Fracture Risk Assessment Tool (FRAX) and request DEXA scan to those who are at high risk as suggested by National Osteoporosis Guidance Group (NOGG) [2,3]. Osteoporosis is defined as bone mineral density of &lt;-2.5 as per the WHO classification [4]. <h3>Objectives</h3> Our objective was to look at prevalence of Osteoporosis in our cohort of patients with RA and to identify factors associated with higher risk for Osteoporosis. <h3>Methods</h3> Data was collected retrospectively using a standardized data collection tool for all the 230 patients who attended the multidisciplinary annual review clinic between Aug 2006 to Aug 2011. Multi nominal Logistic regression analysis was carried to see statistical significance of individual risk factors. <h3>Results</h3> The demographic characteristics of patients in our cohort in showed in the table 1. Out of 230 patients, 152 patients had DEXA scan. 52(23%) patients were already on osteoporosis treatment. Among 101 remaining patients 22(22%) were found to have osteoporosis. Multi nominal Logistic regression analysis shows none of the factors in isolation to be significantly associated with the T-scores &lt;-2.5. Characteristics of patients on osteoporosis treatment or have undergone DEXA Scanning results is as shown in table 2. <h3>Conclusions</h3> In this large retrospective study we found that total of 45% of patients with RA were osteoporotic. This demonstrates importance of screening for osteoporosis in this group of patients as part of annual review. Our study did not show significant correlation between variables associated with patient demographics, disease duration, severity of RA as assessed based on seropositivity, extraarticular features, warranting biologics and osteoporosis. We suggest further research is required into development of composite scores or assays that could predict osteoporosis risk reliably so that DEXA scanning can be more focused. <h3>References</h3> British Society for Rheumatology and British Health Professionals in Rheumatology guideline for the management of rheumatoid arthritis (after the first 2 years) www.shef.ac.uk/FRAX www.shef.ac.uk/NOGG WHO Scientific Group on the Assessment of Osteoporosis at primary Health care level Summary Meeting Report, Brussels, Belgium, 5-7 May 2004 <h3>Disclosure of Interest</h3> None Declared
Abnormal MAG3 Renal Scintigraphy Resulting From Dehydration
Authors: Dwight M. Achong, Luis E. Tenorio
Journal: Clinical Nuclear Medicine (2003)

Routine Tc-99m mercaptoacetyltriglycine (MAG3) renal scintigraphy in a 64-year-old quadriplegic woman revealed normal blood flow with abnormal, continual parenchymal uptake and minimal excretion into the pelvocaliceal collecting systems and urinary bladder. Because there was no clinical reason to suspect acute tubular necrosis, renal artery stenosis, or ureteropelvic junction (UPJ) obstruction, relative dehydration was considered likely. A repeat MAG3 renal scan 6 days later using intravenous fluids to ensure adequate hydration was completely normal. This case highlights the importance of patient preparation to include adequate hydration.
IMPACT OF ROSUVASTATIN ON INSULIN RESISTANCE IN ASIAN POPULATION: TWO-YEAR FOLLOW UP
Authors: Myung-Han Hyun, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Jae Joong Lee, Kwang No Lee, Sunki Lee, Ji Bak Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2015)
METABOLITE PROFILES PREDICT ACUTE KIDNEY INJURY AND MORTALITY IN PATIENTS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Sammy Elmariah, Laurie A. Farrell, Daher Maureen, Xu Shi, Michelle J. Keyes, Carolyn H. Cain, Eugene Pomerantsev, Gus Vlahakes, Ignacio Inglessis, Jonathan Passeri, Igor Palacios, Caroline Fox, Eugene P. Rhee, Robert Gerszten
Journal: Journal of the American College of Cardiology (2016)
OC-160 Telemedicine systems in IBD management—are patients ready?
Authors: J Landy, S T Peake, A Akbar, A L Hart
Journal: Gut (2012)

<h3>Introduction</h3> Inflammatory bowel disease (IBD) is a chronic condition characterised by periods of exacerbations and remission, requiring regular medical follow-up. IBD frequently affects patients of working age and the need for life-long follow-up can have significant personal and societal economic implications. Telemedicine systems, could reduce this burden and have been shown to be successful and highly accepted by patients with other chronic diseases.<sup>1</sup> We aimed to assess the potential technologies by which telemedicine might be employed in our population of IBD patients and the level of patients9 acceptance of telemedicine systems in their management. <h3>Methods</h3> Patients attending the specialist IBD outpatient clinic were surveyed over a 6-week period. Demographic data, access to technology and acceptance of telemedical systems for the management of their disease were assessed. <h3>Results</h3> 52 IBD patients (48%) responded and completed the survey. 52% had a diagnosis of UC; 48% Crohn9s disease. 58% were female. 85% of patients were aged 18–65 years and English was the first language in 86%. 94% of patients had home access to the internet. 56% owned smartphones and 52% used apps regularly. 46% of patients regularly used web video calling. 85% of patients wanted electronic access to their personal health data. 65% and 54% of patients preferred text or email respectively, to be used for reminders of disease monitoring investigations. 65% would choose telephone follow-up, while only 38% would select web based follow-up. 42% of patients indicated they would undertake web supported self-management of their IBD. <h3>Conclusion</h3> IBD patients are of working age and have access to web based and smartphone technologies that could be used in the management of their IBD. IBD patients desire e-health access and the use of technology for communication regarding their disease management as well as web-based monitoring and self management of their IBD. Patients with IBD are ready for telemedicine systems to be employed as an adjunct in the management of their disease. <h3>Competing interests</h3> None declared. <h3>Reference</h3> 1. <b>Mclean S</b>, Protti D, Sheikh A. Tele healthcare for longterm conditions. <i>BMJ</i> 2011;<b>342</b>:d120.
Human Spinal Motor Control
Authors: Jens Bo Nielsen
Journal: Annual Review of Neuroscience (2016)

Human studies in the past three decades have provided us with an emerging understanding of how cortical and spinal networks collaborate to ensure the vast repertoire of human behaviors. Humans have direct cortical connections to spinal motoneurons, which bypass spinal interneurons and exert a direct (willful) muscle control with the aid of a context-dependent integration of somatosensory and visual information at cortical level. However, spinal networks also play an important role. Sensory feedback through spinal circuitries is integrated with central motor commands and contributes importantly to the muscle activity underlying voluntary movements. Regulation of spinal interneurons is used to switch between motor states such as locomotion (reciprocal innervation) and stance (coactivation pattern). Cortical regulation of presynaptic inhibition of sensory afferents may focus the central motor command by opening or closing sensory feedback pathways. In the future, human studies of spinal motor control, in close collaboration with animal studies on the molecular biology of the spinal cord, will continue to document the neural basis for human behavior.
Open abdomen in trauma patients: a double-edged sword
Authors: Yu-hua Huang, You-sheng Li
Journal: Military Medical Research (2016)

The use of open abdomen (OA) as a technique in the treatment of exsanguinating trauma patients was first described in the mid-19th century. Since the 1980s, OA has become a relatively new and increasingly common strategy to manage massive trauma and abdominal catastrophes. OA has been proven to help reduce the mortality of trauma. Nevertheless, the OA method may be associated with terrible and devastating complications such as enteroatmospheric fistula (EAF). As a result, OA should not be overused, and attention should be given to critical care as well as special management. The temporary abdominal closure (TAC) technique after abbreviated laparotomy was used to improve wound healing and facilitate final fascial closure of OA. Negative pressure therapy (NPT) is the most commonly used TAC method.
ERCP after bypass surgery. Which option would patients prefer?
Authors: Yin Zhang, Yu Sheng, Zhining Fan
Journal: Endoscopy (2014)

We read with great interest the article by Law et al., in which the authors introduced their experience of performing a modified endoscopic retrograde cholangiopancreatography (ERCP) with the assistance of transprosthetic endoscopic therapy [1]. The balloon enteroscopy was used to access the excluded stomach. A direct retrograde percutaneous endoscopic gastrostoma was created, and then a fully-covered self-expandable metal stent was deployed within the gastrostomy tract. Finally, a regular ERCP was performed through the percutaneous gastrostoma. The results revealed that this method of modified ERCP is feasible and can be performed during a single endoscopic session in patients with previous Roux-en-Y gastric bypass (RYGB).
AB0923 Subclinical entheseal involvement in patients with psoriasis: A case-control ultrasound study
Authors: A. Nerviani, C. Cerutti, R. Molinari, S. Deidda, D. Sola, M. Steffanini, M. Bellan, M. Pirisi, P.P. Sainaghi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ultrasonography (US) can demonstrate early abnormalities in entheses of asymptomatic patients. The existence of pre-clinical entheseal involvement in patients with psoriasis is debated. <h3>Objectives</h3> To verify by US the presence of subclinical enthesitis in psoriatic patients without clinical features of arthritis/enthesitis. <h3>Methods</h3> We enrolled 47 consecutive patients with a definite diagnosis of psoriasis and 47 sex, age and BMI-matched control. We excluded psoriatic patients treated with systemic drugs or with psoriatic arthritis, with recent trauma or surgery, BMI&gt;30 kg/m<sup>2</sup>, diabetes, dyslipidemia or hyperuricemia. All patients underwent bilateral US scan of the following entheses: flexors and extensors insertion into omeral epicondyle and epitrochlea, quadriceps, proximal and distal patellar ligament, achilles tendon and plantar aponeurosis. Entheses were evaluated for structural (calcifications, enthesophytes and bone erosions) and morphological (increased entheseal thickness of tendon, bursitis, vascular signals Power Doppler) alterations. The Glasgow Ultrasound Enthesitis Scoring System (GUESS) was calculated. US was performed by a rheumatologist trained in musculoskeletal US. Non parametric and chi-square tests were used to compare variables among groups. <h3>Results</h3> Patients and controls were similar for age, BMI and sex distribution (Mann-Whitney U test, p&gt;0.05). Calcifications and enthesophytes were more frequent in psoriatic patients versus controls (55.3% vs 38.3%, χ2, p&lt;0,01). Thickness at the plantar aponeurosis insertion was significantly increased in psoriatic patients in comparison to controls (Mann-Withney U test, p&lt;0.0002). There was a trend (not significant) for a higher GUESS score in psoriatic patients. <h3>Conclusions</h3> In conclusion, abnormal entheseal US features are common in psoriatic patients without clinical enthesitis. Future studies are warranted to verify whether US surveillance may be useful to identify and treat early entheseal involvement in psoriasis, reducing disease burden. <h3>Disclosure of Interest</h3> None Declared
Abstract 1345: The use of optical imaging in a clinically relevant mouse intrafemoral model of leukaemia
Authors: Michael A. Batey, Matthew Brown, Catherine Booth
Journal: Cancer Research (2012)

Abstract One of the challenges facing preclinical development in non solid tumours, such as leukaemia, is the development and validation of clinically relevant models, both to better understand the biology of disease, and to provide reliable efficacy testing for novel agents. In conventional animal models of leukaemia, cells are implanted using intravenous injection, leading to inconsistent engraftment as cells are not introduced directly to their biological niche. Disease burden is measured using either terminal endpoints, such as hind limb paralysis, or by fluorescence activated cell sorting on bone marrow or peripheral blood samples. Neither of these strategies make it practical to identify animals in the early stages of leukemic disease development, limiting investigators’ ability to examine novel therapies in these models. The use of preclinical imaging strategies, such as in vivo optical imaging, allows disease progression to be followed at orthotopic sites and, in the case of non solid tumours, to monitor systemic disease burden longitudinally in an individual animal over time. Here we describe the use of an intrafemoral (i.f.) transplantation method, in which cells are implanted directly into the biological niche of interest, correlating with the environment in which disease develops in patients. Luciferase-labelled human leukaemia cell lines were injected into the bone marrow cavity of the femur of severely immunocompromised NOG (NOD/Shi-scid/IL-2Rynull) mice via the knee joint. Animals were followed over a period of several weeks from initial transplantation, and disease burden monitored and quantified using bioluminescent detection. This model consistently gives rise to disease disseminating gradually from the site of initial transplantation into systemic leukaemia. The ability to quickly identify engraftment and the predictable development of disease allows for therapeutic intervention at an early stage and extends the window available for therapy. The model provides a clinically relevant environment for the preclinical assessment of novel therapeutics for non solid tumours. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1345. doi:1538-7445.AM2012-1345