tbuckley/cabot-search huggingface dataset:
AB1067 Ultrasound Assessment of Rheumatoid Arthritis Patients on Biological Therapy Using A 12 Joint Score – Sonographic Findings
Authors: M. Cerqueira, F. Teixeira, J. Sousa Neves, D. Peixoto, J.A. Costa, M.C. Afonso
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Ultrasound (US) evaluation is becoming increasingly more used to assess patients with Rheumatoid Arthritis and other rheumatic diseases, not only for diagnostic purposes, but also to assess disease activity and support therapeutic decisions. <h3>Objectives</h3> Identify the inflammatory US findings on RA patients on biological DMARDs (bDMARDs) using a 12-joint assessment and an US score based on the presence of synovitis or tenosynovitis and Power Doppler (PD) signal. <h3>Methods</h3> Forty one patients diagnosed of Rheumatoid Arthritis, on bDMARDs, followed in our day-care hospital unit, were evaluated using a 12 joint US assessment (bilateral elbow, wrist, 2nd metacarpophalangeal (MCP), 3rd MCP, knee, ankle) within 3 hours of the routine clinical examination. The US assessment was performed by the same Rheumatologist, blinded to the clinical and laboratory findings; the Rheumatologists who made the clinical assessment were blinded to US evaluation. Both synovitis and PD were graded semi quantitatively from 0-3; the final US score was the sum of the highest synovitis and PD scores at each joint. Joints surgically replaced were excluded. <h3>Results</h3> The mean years of disease since diagnosis was 13.97±5.76. Fifteen patients were treated with Etanercept, 6 with Adalimumab, 6 with Tocilizumab, 5 with Infliximab, 5 with Rituximab and 4 with Golimumab. The mean clinically assessed DAS28 was 3.07±1.16. A total of 484 joints were assessed. Synovitis and PD were found in 24% and 3% of the ankles, 21% and 17% of the wrists, 19% and 9% of the 2nd MCP, 7% and 2% of the 3rd MCP, 6% and 0% of the knees and 5% and 0% of the elbows, respectively. The assessment of US disease activity in the ankle was largely due to tenosynovitis of the <i>tibialis posterior</i> which was found in 19% of the cases. The mean US score was 3.22±5.12 with a range from 0 to 30, with a mean synovitis score of 2.51±4.24 and a mean PD score of 0.71±1.27. <h3>Conclusions</h3> The ankle, a joint not included in the DAS28, was the joint that expressed more frequently US disease activity, mainly due to the presence of tenosynovitis of the <i>tibialis posterior</i>. Tenosynovitis of this tendon may be difficult to clinically detect and is associated with a progressive flat foot deformity. The wrist and 2nd MCP were the joints with highest combined synovitis and PD score, which may be in agreement with the known frequent erosive and destructive evolution of these joints in RA patients. <h3>References</h3> Naredo, E., et al., Validity, reproducibility, and responsiveness of a twelve-joint simplified power doppler ultrasonographic assessment of joint inflammation in rheumatoid arthritis. Arthritis Care &amp; Research, 2008. 59(4): p. 515-522. <h3>Disclosure of Interest</h3> None declared
AB0836 The Evaluation of Cardiovascular Risk in Hand Osteoarthritis Included Erosive Hand Osteoarthritis
Authors: A.M. Bumbea, R. Traistaru, A.E. Musetescu, A. Bighea, R. Popescu, A. Stefanescu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The aim of our study is to put in evidence the correlation between clinical manifestation in hand osteoarthritis and the level of damage determinated by this disease and the cardiovascular risk. It is known that the heart and hand have a commune embryologic origin of vascularisation which could be the connection of hand osteoarthritis and coronary disease. <h3>Objectives</h3> Our purpose is to establish a statistical correlation between the gravity of hand osteoarthritis and the cardiovascular risk. <h3>Methods</h3> We included in this study a cohort of 120 patients with osteoarthritis, 27 with erosive osteoarthritis, as a study group, compared with a similar group, as a control group, without clinical manifest osteoarthritis. All patients were evaluated clinical and perform hands sonography for osteoarthritis. We assess the number of painful joint by visual analogue scale and the mobility by articular testing using goniometry. We also perform sonography in the same joint, and evaluate the joint space, the presence of spur and or erosions. We evaluated sonographic the patients once per year, and clinical twice per year. The cardiovascular assess consist in measuring the blood pressure, electrocardiography performed at six months, and monitories the history of cardiovascular events or stroke. All patients admitted in this study were age over 50, and we excluded from study metabolic comorbidities, as diabetes mellitus, dislipidemia, hyperuricemia. The study was retrospective and lasted for four years. <h3>Results</h3> In the study group we assist to more cardiovascular events, more specific in subgroup with erosive osteoarthritis where 3 patients develop an ischemic stroke, and 8 patients develop an ischemic coronary disease, only one with acute ischemic heart disease. The other part of patients of study group had a progression of ischemic myocardial disease in percent of 31,3 more than control group, and 21 patients develop a stroke, 8 of them were transitory ischemic stroke. <h3>Conclusions</h3> The presence of severe osteoarthritis could be a risk factor to develop coronary disease or stroke, probably there is more factors not establish until now. <h3>References</h3> Haugen IK, Ramachandran VS, Misra D, Neogi T, Niu J, Yang T, Zhang Y, Felson DT. Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham Heart Study. Ann Rheum Dis. 2015 Jan;74(1):74-81. doi: 10.1136/annrheumdis-2013-203789. Epub 2013 Sep 18. Sid Kirchheimer, Finger Arthritis Predicts Heart Disease, Or Does New Study Touch on "Merger" of Both Conditions? WebMD Health News, http://www.webmd.com/arthritis/news/20030115/finger-arthritis-predicts-heart-disease. <h3>Disclosure of Interest</h3> None declared
Role of Retinoids in Differentiation and Carcinogenesis&lt;xref ref-type="fn" rid="FN1"&gt;*&lt;/xref&gt;
Authors: Michael B. Sporn
 †, Anita B. Roberts
Journal: JNCI Journal of the National Cancer Institute (1984)

Role of Retinoids in Differentiation and Carcinogenesis Get access Michael B. Sporn, Michael B. Sporn † Laboratory of Chemoprevention, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205 †Address reprint requests to Dr. Sporn, Building 41, Room D224, National Institutes of Health, Bethesda, Md. 20205. Search for other works by this author on: Oxford Academic PubMed Google Scholar Anita B. Roberts Anita B. Roberts Laboratory of Chemoprevention, Division of Cancer Cause and Prevention, National Cancer Institute, Bethesda, Maryland 20205 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 73, Issue 6, December 1984, Pages 1381–1387, https://doi.org/10.1093/jnci/73.6.1381 Published: 01 December 1984
Current need versus treatment history as predictors of use of outpatient psychiatric care
Authors: M J Friedman, A N West
Journal: American Journal of Psychiatry (1987)

The authors conducted a study of treatment utilization and outcome on a sample of 116 psychiatric outpatients at a Veterans Administration (VA) hospital. Utilization and outcome measures were obtained at a follow-up interview 18 months after a baseline assessment. Comparisons between patients with high and low rates of utilization revealed negligible relationships between use of services and severity of illness, clinical change, or demographics. However, previous use of VA outpatient and inpatient psychiatric services and VA psychiatric disability rating predicted utilization of psychiatric care during the study. The authors conclude that use of VA outpatient psychiatric care may reflect patients' help-seeking history more than their current clinical need.
PTU-090 Prevalence and impact of irritable bowel type-symptoms in quiescent inflammatory bowel disease
Authors: DJ Gracie, CJ Williams, R Sood, S Mumtaz, H Bholah, PJ Hamlin, AC Ford
Journal: Gut (2015)

<h3>Introduction</h3> The prevalence of symptoms compatible with irritable bowel syndrome (IBS) in inflammatory bowel disease (IBD) has been previously described.<sup>1</sup>However, the association between the presence of these symptoms and occult disease activity is less well known, as is the effect of these symptoms on psychological health. We conducted a cross-sectional survey examining these issues. <h3>Method</h3> Demographic and gastrointestinal symptom data were collected from 439 adult patients via the Rome III questionnaire. IBD activity was assessed via clinical scoring systems and faecal calprotectin (FC). Mood was assessed using the hospital anxiety and depression scale, whilst somatisation and quality of life data were collected using the patient health questionnaire-12 (PHQ-12) and SF-36 questionnaire respectively. Mean FC, as well as anxiety, depression and somatisation severity and quality of life were compared between CD and UC patients meeting Rome III criteria for IBS and those who did not. <h3>Results</h3> More patients with CD met criteria for IBS than UC (97 (42.4%) of 229 vs. 63 (30.9%) of 204 respectively, P = 0.01). In CD, there was no difference in anxiety (P = 0.106), depression (P = 0.156) or somatisation severity (P = 0.104) in patients with IBS-type symptoms versus those without. Mean quality of life scores for pain (P = 0.003) and general health (P = 0.009) were significantly lower in CD patients with IBS-type symptoms. In contrast, in UC anxiety severity was higher in those with IBS-type symptoms (P = 0.001), and there was a trend towards greater depression and somatisation severity in patients with IBS-type symptoms (P = 0.035 and P = 0.011 respectively). UC patients with IBS-type symptoms had significantly lower mean quality of life scores for role limitations due to physical health (P = 0.004), energy/fatigue (P = 0.003), emotional wellbeing (P = 0.002), social functioning (P = 0.006), pain (P &lt; 0.001) and general health (P = 0.003). Mean FC levels were higher in those with IBS-type symptoms than those without in CD (543.3 vs. 444.9; P = 0.529) and UC (423.5 vs. 282.8; P = 0.368). There was no difference in the proportion of individuals with a normal FC in CD patients fulfilling criteria for IBS (12 (63.2%) of 19) than those not (31 (56.4%) of 55) (P = 0.605). The same was true in UC (7 (50%) of 14 vs. 38 (69.1%) of 55 (P = 0.181). <h3>Conclusion</h3> The prevalence of IBS-type symptoms is higher in CD than in UC. IBS-type symptoms are associated with more severe anxiety in UC patients and lower quality of life scores in both CD and UC. Whether such symptoms arise from occult disease activity, or true coexistence of IBS, remains unclear. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Halpin SJ, Ford AC. Am J Gastroenterol. 2012;107(10):1474–82
Ambient Fine Particulate Matter, Nitrogen Dioxide, and Preterm Birth in New York City
Authors: Sarah Johnson, Jennifer F. Bobb, Kazuhiko Ito, David A. Savitz, Beth Elston, Jessie L.C. Shmool, Francesca Dominici, Zev Ross, Jane E. Clougherty, Thomas Matte
Journal: Environmental Health Perspectives (2016)

Background:Recent studies have suggested associations between air pollution and various birth outcomes, but the evidence for preterm birth is mixed.Objective:We aimed to assess the relationship between air pollution and preterm birth using 2008–2010 New York City (NYC) birth certificates linked to hospital records.Methods:We analyzed 258,294 singleton births with 22–42 completed weeks gestation to nonsmoking mothers. Exposures to ambient fine particles (PM2.5) and nitrogen dioxide (NO2) during the first, second, and cumulative third trimesters within 300 m of maternal address were estimated using data from the NYC Community Air Survey and regulatory monitors. We estimated the odds ratio (OR) of spontaneous preterm (gestation < 37 weeks) births for the first- and second-trimester exposures in a logistic mixed model, and the third-trimester cumulative exposures in a discrete time survival model, adjusting for maternal characteristics and delivery hospital. Spatial and temporal components of estimated exposures were also separately analyzed.Results:PM2.5 was not significantly associated with spontaneous preterm birth. NO2 in the second trimester was negatively associated with spontaneous preterm birth in the adjusted model (OR = 0.90; 95% CI: 0.83, 0.97 per 20 ppb). Neither pollutant was significantly associated with spontaneous preterm birth based on adjusted models of temporal exposures, whereas the spatial exposures showed significantly reduced odds ratios (OR = 0.80; 95% CI: 0.67, 0.96 per 10 μg/m3 PM2.5 and 0.88; 95% CI: 0.79, 0.98 per 20 ppb NO2). Without adjustment for hospital, these negative associations were stronger.Conclusion:Neither PM2.5 nor NO2 was positively associated with spontaneous preterm delivery in NYC. Delivery hospital was an important spatial confounder.Citation:Johnson S, Bobb JF, Ito K, Savitz DA, Elston B, Shmool JL, Dominici F, Ross Z, Clougherty JE, Matte T. 2016. Ambient fine particulate matter, nitrogen dioxide, and preterm birth in New York City. Environ Health Perspect 124:1283–1290; http://dx.doi.org/10.1289/ehp.1510266
Treatment of resistant lithium-induced nephrogenic diabetes insipidus and schizoaffective psychosis with carbamazepine
Authors: S C Brooks, B E Lessin
Journal: American Journal of Psychiatry (1983)

A man with resistant lithium-induced nephrogenic diabetes insipidus and affective psychosis was successfully treated with carbamazepine. Carbamazepine may be appropriate for concurrently treating lithium-induced renal dysfunction and manic-depression in patients whose prognosis may be jeopardized by lithium discontinuation.
AB1235-HPR Chronic Neck Pain Influences Jaw Muscles Recruitment During a Biting Task
Authors: M. Testa, T. Geri, L. Gizzi, F. Petzke, D. Falla
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Mastication requires a high degree of coordination between jaw and neck muscles. The spino-trigeminal system supports the hypothesis that the presence of pain in one of these two regions could affect the motor behaviour of the other. While experimental evidences showed that patients with temporomandibular disorders display electromyographic alterations of the neck flexor and extensor muscle (Armijo-Olivo and Magee, 2013), alterations of the jaw muscles in patients with neck pain have not been investigated yet. <h3>Objectives</h3> To investigate precision, accuracy and electromyographic activity of jaw muscles contraction during a unilateral bite task in subjects with neck pain. <h3>Methods</h3> Ten subjects with chronic neck pain and an age and gender-matched sample of healthy individuals volunteered for this study. The maximal voluntary bite force (MVC) was measured with a flexible force transducer positioned between the first molar teeth and used to set up a biting task requiring the subjects to match 4 targets (10, 30, 50 and 70%MVC) displayed on a computer monitor. Electromyographic (EMG) signals of the masseter and anterior temporalis muscles were recorded bilaterally. The subject9s force performance was measured using error indices from the reference target like the Mean Distance (MD), Offset Error (OE) and the Standard Deviation (SD) of the delivered force. The Root Mean Square (RMS) of the electromyogram was calculated to detect differences in muscular activity. Between-group differences of the force indices (MD, OE, SD) and EMG activity (RMS) were assessed through Kruskal-Wallis test significance level was set to 0.05. <h3>Results</h3> There were no significant between-group differences in force production for MD (H =0.38, P=0.5), OE (H =1.81, P=0.2) and SD (H =0.26, P=0.6). A significant difference in electromyographic activity was however detected for the masseter muscle (H =7.19, P=0.007, please refer to Figure) but not for temporalis (H =3.82, P=0.05). <h3>Conclusions</h3> This study demonstrates that patients with neck pain present higher masticatory muscle activity during a unilateral biting task. Our results support the strong functional relationship between temporomandibular and neck regions and invite to consider, also in clinical setting, the possibility that a disorder affecting one region can have consequences on the functionality of the other. In fact, even though the motor output was comparable between groups, subjects with neck pain displayed higher RMS activity of masseter muscle to deliver the same force. <h3>References</h3> Armijo-Olivo S, Magee D. Cervical musculoskeletal impairments and temporomandibular disorders. J Oral Maxillofac Res. 2013;3:e4. <h3>Disclosure of Interest</h3> None declared
FRI0405 Prednisone Increases Both Arterial and Venous Thrombosis in SLE: Table 1.
Authors: K. Hickman, L. Magder, M. Petri
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> An increasing number of studies have investigated factors that are associated with thrombosis in SLE. However, few have examined risk factors specific for venous thrombosis in patients with SLE and no study to date has compared the relative influence of risk factors on venous versus arterial thrombosis prospectively. <h3>Objectives</h3> We examined the effect of traditional and disease specific risk factors on both venous and arterial thrombosis. <h3>Methods</h3> The analysis is based on 1951 patients who were enrolled in a prospective cohort from April 1987 through September 2014. In 12,638 person years of follow up, 189 thrombotic events were observed. We fit separate multivariable models for venous and arterial thrombosis that included variables that were most important based on the age-adjusted and preliminary regression models. <h3>Results</h3> Table 1 includes variables that were independently associated with thrombosis. Even after controlling for all the other variables in the model, there was a strong association between recent systolic blood pressure, diabetes and current prednisone dose on both venous and arterial thrombosis. Recent cholesterol was an independent risk factor only for venous thrombosis but not arterial thrombosis. Current Plaquenil use was protective only against venous thrombosis. A history of lupus anticoagulant was associated with an increased risk of venous thrombosis, but was not significant for arterial thrombosis (p=0.17.) A history of low C3 was associated with an increased risk of venous thrombosis whilst recent low C3 was more important than a history of low C3 when considering arterial thrombosis. <h3>Conclusions</h3> Venous or arterial thromboses are equally associated with modifiable risk factors such as blood pressure and diabetes (however only venous thrombosis was associated with cholesterol in the multivariate model). Current use of prednisone at a dose greater than 20mg increased the risk of both arterial and venous thrombosis more than any other risk factor. <h3>Disclosure of Interest</h3> None declared
Study Links Periodontal Disease Bacteria to Pancreatic Cancer Risk
Authors: Julie A. Jacob
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Accuracy of estimating genetic distance between species from short sequences of mitochondrial DNA.
Authors: A P Martin, B D Kessing, S R Palumbi
Journal: Molecular Biology and Evolution (1990)

Recent advances in molecular techniques allow rapid determination of genetic divergence, and in many circumstances the polymerase chain reaction (PCR) and DNA sequencing have become the technologies of choice for estimating genetic distance.For evolutionary studies, considerable effort is being focused on "universal"
Frontal, temporal, and striatal proton relaxation times in schizophrenic patients and normal comparison subjects
Authors: P Williamson, D Pelz, H Merskey, S Morrison, S Karlik, D Drost, T Carr, P Conlon
Journal: American Journal of Psychiatry (1992)

Spin-lattice (T1) and spin-spin (T2) magnetic resonance relaxation times were examined in frontal, temporal, and striatal regions of 24 patients with schizophrenia and 10 normal comparison subjects. The schizophrenic patients had more prolonged T2 values than did the comparison subjects, particularly in the left temporal cortex and white matter, suggesting tissue pathology.
Technique to eliminate mitochondrial disease carries very small risk of failure, researchers find
Authors: Jilna Shukla
Journal: BMJ (2016)

A team of researchers from Newcastle, UK, have described a new technique that may reduce the risk of serious inherited diseases, although they warned of a small risk that the procedure will fail.

Last February the United Kingdom became the first country in the world to allow mitochondrial donation to prevent serious genetic inherited diseases, after the House of Lords voted in favour of a change in the law to permit new in vitro fertilisation (IVF) techniques.1 The researchers at Newcastle, led by Mary Herbert and Doug Turnbull, have become the first to develop a method called pronuclear transfer (PNT).2

About one person in 10 000 …
The Future of Pathology
Authors: A Barros
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal