tbuckley/cabot-search huggingface dataset:
The Behavior of Cytogenetic/Molecular Markers Associated with JAK2 Mutation Status Before and After Primary Myelofibrosis Progression Supports the Hypothesis of the Leukemic Clone's Independence From the JAK2 Mutation
Authors: Francesco Albano, Antonella Zagaria, Luisa Anelli, Nicoletta Coccaro, Giuseppina Tota, Angela Minervini, Luciana Impera, Crescenzio Francesco Minervini, Alessandra Ricco, Domenico Pastore, Mario Delia, Paola Casieri, Giorgina Specchia
Journal: Blood (2012)
Codanin-1, the Protein Encoded by the Gene Mutated in Congenital Dyserythropoietic Anemia Type I (CDAN1), Is Cell Cycle Regulated
Authors: Sharon Noy-Lotan, Orly Dgany, Roxane Lahmi, Nathaly Marcoux, Tanya Krasnov, Nissan Yissachar, Doron Ginsberg, Benny Motro, Peretz Resnitzky, Isaac Yaniv, Gary Kupfer, Hannah Tamary
Journal: Blood (2008)
Surgical learning activities for house officers - Do they improve the surgical experience?
Authors: R. Maweni, R. Foley, M. Lupi, D. Shier, R. O'Connell, S. Vig
Journal: International Journal of Surgery (2016)

To ascertain whether house officers (HOs) attain a more satisfactory surgical rotation experience when they perform basic surgical learning activities. We also sought to establish how many and which learning activities HOs achieve and the effect on their surgical experience. A questionnaire listing 20 learning activities and questions regarding satisfaction with an overall experience was disseminated to HOs in the UK and Ireland who had completed ≥3 months of surgical rotations. Satisfaction with surgical experience was dichotomised in order to perform logistic regression using R Studio software v0.98. The survey was completed by 150 respondents, with 26 % completing at least 10 basic surgical learning activities during their surgical rotation. On multivariate analysis, the completion of these learning activities was significantly associated with a satisfactory rotation experience (p < 0.001). Furthermore, the use of a checklist of surgical activities provided to HOs was associated with a significant increase in the performance of learning activities (p = 0.003). Surgical HOs who were informed about potential basic surgical learning activities that can be performed during their rotations performed significantly more of these activities. And these activities were associated with a significantly greater satisfaction with surgical rotations. Therefore, we recommend facilitating HOs completion of these activities as this will ensure that basic surgical competencies are achieved and that HOs will be more satisfied with their surgical experience.
SP0108 Different Approaches To Drug Approval by EMA and FDA – The Example of Non-Radiographic Axial Spondyloarthritis
Authors: J. Sieper
Journal: Annals of the Rheumatic Diseases (2016)

Recently new classification criteria have been developed for axial spondyloarthritis (SpA) covering both patients who already show radiographic evidence of structrual damage in the sacroilac joints (or spine), termed radiographic axila SpA (or using the older term: ankylosing spondylitis (AS)) and patients in the earlier phase without radiographic evidence of structural damage in the bone, termed non-radiographic (nr) axial SpA. There is general agreement that these two stages represent a continuum of the same disease and that preferentially the term axial SpA should be used. Both EMA and FDA have raised questions about the natural course of the earlier stage (nr-axSpA), the potential rate of spontaneous remission and the possibilty of overtreatment with biologcs in these patients. However, the EMA has accepted that there was an unmet need for treatment with TNF-blockers of these patients if they fail conventional therapy, which resulted in an approval for TNF-blockers for nr-axSpA - in addition to patients with AS - in the EU, if they have objective signs of inflammation such as positive CRP and/or active bone inflammation on MRI, and many other countries but not the US. The EMA has demanded post-approval studies from the TNF-blocker companies investigating what happens if the drug is stopped (or the dosage reduced) in patients who are reaching remission. These studies are ongoing and will deliver sufficient informations whether overtreatment might occur in these patients. In contrast, the FDA is asking for further phase 3 trials which include a placebo-controlled phase over 12 months. Such a study design would be very difficult to be conducted in EU countries – withholding an effective drug up to 12 months from active patients. But the different apporaches used by the two agencies also reflect that European rheumatologists have been much more familiar over the last decades with this early phase of axSpA compared to US rheumatologists. It is hoped that the results of the ongoing trials - in Europe, US and other parts oft he world – will result in a worldwide acceptance of the axial SpA concept and of the need to offer adaequate treatment to all axial SpA patients in their active phase. <h3>Disclosure of Interest</h3> None declared
SP0116 How To Use MRI To Differentiate SPA from Its Differential Diagnoses?
Authors: T. Diekhoff
Journal: Annals of the Rheumatic Diseases (2016)

Magnetic resonance imaging (MRI) in axial spondyloarthritis has an increasing importance, especially in patients without or with equivocal changes in radiography. However, radiologists are often uncomfortable with imaging of rheumatic diseases and reports consequently sometimes confusing. Therefore, rheumatologists are increasingly confronted with the need to receive their own impression of radiography and MR images. The aim of this talk is to give basic ideas on interpretation of MRI sequences with a focus on the sacroiliac joints in a case-based manner. The participants will learn to easily differentiate common MR sequences and to decide, which information can be derived of an image. They will discover to detect common differential diagnoses (such as condensing osteitis, osteoarthritis and anatomical variants) and to differentiate them from inflammatory changes. In a comparison of radiography, MRI and computed tomography they will experience the strengths and weaknesses of the different imaging methods and learn to decide, in which patients further imaging – additional to MRI – may be useful. This talk will also provide a perspective of future innovations in MRI and what additional advantages might go along with them. In the end, the experience might encourage an intensified communication between rheumatologists and radiologists in daily practice with a better understanding of the thinking and needs within the respective medical field. <h3>Disclosure of Interest</h3> None declared
HIV Transmission During Condomless Sex With a Seropositive Partner With Suppressed Infection—Reply
Authors: Anna Maria Geretti, Alison J. Rodger, Jens Lundgren
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Climate Change and Health
Authors: Erik Mondrow
Journal: Annals of Internal Medicine (2016)

Letters15 November 2016Climate Change and HealthErik Mondrow, MDErik Mondrow, MDFrom Flatiron Internal Medicine, Louisville, Colorado.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0413 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I read with dismay Crowley's position paper calling for “urgent action” on climate change (1). With egregious overreach, the American College of Physicians (ACP) abandoned its expertise in medicine to preach about atmospheric science. This should strike physicians with the same incredulity that we would feel if the National Oceanic and Atmospheric Administration were to issue a policy on best practices for managing diabetes. This ACP position paper tarnishes the College's distinguished reputation by seeming to promote a biased political agenda.As soon as I read “ninety-seven percent of climate scientists agree that humans are largely causing ...References1. Crowley RA; Health and Public Policy Committee of the American College of Physicians. Climate change and health: a position paper of the American College of Physicians. Ann Intern Med. 2016;164:608-10. [PMID: 27089232]. doi:10.7326/M15-2766 LinkGoogle Scholar2. Cook J, Nuccitelli D, Green SA, Richardson M, Winkler B, Painting R, et al. Quantifying the consensus on anthropogenic global warming in the scientific literature. Environ Res Lett. 2013;8. CrossrefGoogle Scholar3. Tuttle I. The 97 percent solution. National Review. 8 August 2015. Accessed at www.nationalreview.com/article/425232 on 9 October 2016. Google Scholar4. Lomborg B. Impact of current climate proposals. Global Policy. 2016;7:109-18. doi:10.1111/1758-5899.12295 CrossrefGoogle Scholar5. Zhu Z, Piao S, Myneni RB, Huang M, Zeng Z, Canadell JG, et al. Greening of the Earth and its drivers [Letter]. Nature Climate Change. 2016;6:791-5. doi:10.1038/nclimate3004 CrossrefGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Flatiron Internal Medicine, Louisville, Colorado.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0413. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoClimate Change and Health: A Position Paper of the American College of Physicians Ryan A. Crowley and Climate Change and Health Eric J. Reines Climate Change and Health Ryan A. Crowley , Darilyn V. Moyer , and Douglas M. DeLong Climate Change and Health Daniel S. Berman Metrics 15 November 2016Volume 165, Issue 10Page: 745-746KeywordsClimate changeConflicts of interestDisclosureForecastingScientistsTemperature ePublished: 15 November 2016 Issue Published: 15 November 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Poorer Relapse-Free Survival in Hispanic Children Diagnosed with Acute Myeloid Leukemia Compared with Non-Hispanics: A Texas Single Institution Experience
Authors: Aditya Deshpande, Maria Monica Gramatges, Ghadir S. Sasa, Philip J Lupo, Rachel E Rau, Michele S. Redell, Terzah M. Horton, Michael E Scheurer, Karen R. Rabin
Journal: Blood (2015)
Identification of Multiple Promoter Associated CpG Islands Commonly Methylated in Both Acute Lymphocytic Leukemia (ALL) and Chronic Lymphocytic Leukemia(CLL) Using Novel Genome-Wide Microarray Technique: Implications for Common Primordial Molecular Pathways in Lymphoid Leukemias.
Authors: Weigang Tong, Shao-Qing Kuang, William Wierda, Michael J. Keating, Guillermo Garcia-Manero
Journal: Blood (2008)
Elevated Involved Light Chains Discordant to the Increase of the Involved Heavy Chains Identifies a Subset of Multiple Myeloma Patients with Worse Outcome
Authors: Erel Joffe, Yael C Cohen, Irit Avivi, Noam Benyamini, Svetlana Trestman, Viki Held, Meletios A. Dimopoulos, Efstathios Kastritis
Journal: Blood (2014)
THU0183 Treatment with Tofacitinib Inhibits Human Naïve B Lymphocyte Development and Function In Vitro
Authors: J. Thiel, K. Fischer, R.E. Voll, R. Lorenzetti, B. Bannert, N. Venhoff, M. Rizzi
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> B cells are pivotal to the pathogenesis of many autoimmune diseases including rheumatoid arthritis (RA). Tofacitinib, a JAK inhibitor, is effective and safe in the treatment of RA. Tofacitinib interferes with signal transduction via cytokine receptors using the common γ-chain. <h3>Objectives</h3> Despite of extensive data on T lymphocytes, the impact of tofacitinib on B lymphocytes is poorly understood. In this study we assess the effect of tofacitinib on the differentiation of naive B-lymphocytes and their function. <h3>Methods</h3> Sorted human B cells from cord blood or buffy coat were stimulated in the presence of increasing doses of tofacitinib. B cell phenotypes were determined by flow cytometry. Immunoglobulin concentrations were measured by ELISA. The expression of B cell fate determining genes PRDM1, IRF4, XBP1, and AICDA was analyzed by quantitative RT-PCR. <h3>Results</h3> Tofacitinib treatment strongly impaired plasmablast development, immunoglobulin secretion and induction of PRDM1, IRF-4, and XBP-1 from naive B cells. Interestingly, class switch and AICDA induction from activated naive B cells was only slightly reduced. B cells purified from buffy coats, including naive and memory B cells, stimulated in the presence of tofacitinib, showed only a moderate reduction in plasmablast formation, immunoglobulin secretion and proliferation. <h3>Conclusions</h3> We demonstrated that tofacitinib has a direct impact on human naive B-lymphocytes, independently from its effect on T lymphocytes, by impairing their development into plasmablasts and immunoglobulin secretion. Tofacitinib predominantly affects naive B lymphocytes, while its effect on total peripheral B cells containing naive and memory B cells is less pronounced. Our data are of clinical importance as they suggest that vaccinations should be performed prior to tofacitinib treatment. Furthermore, impairement of B cell function by tofacitimib may directly contribute to its therapeutic effects. This fact has implications for the potential use of tofacitinib in B cell-mediated diseases. <h3>Disclosure of Interest</h3> None declared
OP0088 Inflammation on MRI of The Spine Is Longitudinally Related To Disease Activity in Smokers but Not in Non-Smokers in Axial Spondyloarthritis: 2-Year Data from The Desir Cohort:
Authors: V. Navarro-Compán, S. Ramiro, R. Landewé, M. Dougados, C. Miceli-Richard, P. Richette, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> In axSpA, the effect of disease activity on radiographic progression over time is more pronounced in males and smokers, but the reason for this is unclear. Recently, we have demonstrated a longitudinal relationship between MRI-inflammatory lesions and clinical disease activity measures (DA) in males, but not in females. However, whether or not there is also a disparity in this relationship based on the smoking status is unknown. <h3>Objectives</h3> To investigate the role of smoking status in the longitudinal relationship between inflammatory lesions on MRI of the spine and DA in patients with axSpA. <h3>Methods</h3> Two-year follow-up data from 164 patients fulfilling ASAS axSpA criteria in the DESIR cohort with ≥2 MRIs of the spine available during this period were analysed. Interactions were tested between smoking status and DA (ASDAS, BASDAI, patient9s global disease activity, night pain, CRP and ESR) on the longitudinal relationship with MRI of the spine (Berlin score), analysed with a GEE model of i) absolute and ii) change scores. All models were adjusted for age, symptom duration and HLA-B27. Since there was a significant interaction with gender in previous analyses, analyses were repeated in males and females separately. <h3>Results</h3> Baseline characteristics of patients included were: 50% males, mean (SD) age: 33 (9) years, 39% smokers, 82% HLA-27+ and symptom duration: 18 (11) months. A significant interaction with smoking status was found for most of the DA, indicating that the relationship between MRI-inflammatory lesions and DA was different in smokers than in non-smokers. In the model of absolute scores (i), MRI-scores were statistically significantly related to most of the DA in smokers, while only CRP was significantly and weakly related in non-smokers (Table 1A). In the model of changes (ii), ASDAS and pain at night remained significantly related to MRI-inflammatory lesions, but no statistically significant relationship between MRI and DA was found in non-smokers (Table 1B). When stratifying for gender, the subgroups were small and the relationships were no longer statistically significant. <h3>Conclusions</h3> In patients with axSpA, there is a longitudinal relationship between MRI inflammatory lesions of the spine and DA in smokers, but not in non-smokers. This disparity may explain the stronger effect of disease activity on radiographic progression observed in smokers. Whether both gender and smoking have an effect on this relationship between MRI and DA remains to be elucidated. <h3>Acknowledgement</h3> Pfizer <h3>Disclosure of Interest</h3> None declared
Allogeneic Hematopoietic Stem Cell Transplantation with Clofarabine/Busulfan × 4 (CloBu4) Conditioning Exhibits Significant Anti-Tumor Activity In Non - Remission Hematologic Malignancies, Especially In AML
Authors: Shin Mineishi, John Magenau, Hiromi Tobai, Attaphol Pawarode, Edward M. Peres, Pavan Reddy, Carrie Kitko, Sung Choi, Harry P Erba, Lisa Kujawski, Gregory Yanik, James Ferrara, John E. Levine
Journal: Blood (2010)
OC-058 Perspectives of Adolescent IBD Patients Undergoing Surgery
Authors: K Ashton, S Myers, E Whitehead, S Sebastian
Journal: Gut (2016)

<h3>Introduction</h3> There is limited data on the concerns experiences of adolescent IBD patients in relation to surgery in a period of significant physical and emotional changes in their lives in addition to the added burden of a chronic disease. Understanding this may impact on the provision of care that is provided for these young patients for decision making, coping skills and overall adjustment. We aimed to study the experiences and concerns in adolescent IBD patients undergoing surgery to facilitate development of a programme aimed at improving this area of care. <h3>Methods</h3> This was a qualitative questionnaire study. IBD patients between the ages of 18–24 with history of surgery for IBD during adolescent years were invited to participate and informed consent was obtained. All had undergone structured transition into adult services from paediatric care. <h3>Results</h3> 24 patients (12 males, 12 females) were included. 23 patients included had Crohn’s disease. 16 (66.6%) had undergone resection and 6 (37.5%) had resulted in a stoma, 3 of which was permanent. 6 (25%) had undergone EUA with drainage and Seton insertion for perianal CD. Two patients underwent gastrojejunostomy and I patient had panproctocolectomy. Four patients (16.6%) had multiple surgeries. The main concerns pre surgery were: physical changes of having a scar or stoma (17 Patients, 71%), being away from family, friends and partners (17 patients, 71%) and anxiety regarding post-operative complications (13 patient, 54%). All patients discussed their concerns with family and friends but only 15 (62.5%) spoke with their Consultant or IBD/Stoma Nurse regarding their concerns. Of the 17 (70.83%) who had opportunity to speak to other patients, only 8 found this to be beneficial. Majority (20, 83%) accessed literature in preparation for their procedure but 8 (40%) felt this provided little or no help to them. Post procedure, all patients felt they got support from friends and family. In addition 8 had (45.8%) turned to a partner for support. Use of support from health care professionals was not mentioned. Coping strategies post-operatively by patients varied greatly and included family support, and spiritual support. However in a proportion of patients there were significant difficulties in coping post-surgery leading to ‘giving up’, self-blame and substance and/or alcohol use. Despite this Only 1 (4.1%) patient wished they had not gone ahead with it. Concerns regarding residual surgical scars were reported by only 5 (20.8%) patients. <h3>Conclusion</h3> This study gives valuable insights into young people’s concerns and experiences when facing surgery for their IBD and areas of intervention which will benefit. Personalised approach to these patients in their most vulnerable stage of life would be beneficial and an IBD nurse involved in transition may be an integral part in providing this. <h3>Disclosure of Interest</h3> None Declared
Evaluation of MRD Status by Flow Cytometry and PCR in Multiple Myeloma Elderly Patients Receiving Autologous Stem Cell Transplantation After Bortezomib-Supplemented Mobilization and Conditioning
Authors: Immacolata Attolico, Roberta Nuccorini, Alberto Fragasso, Vincenzo Pavone, Pellegrino Musto, Silvana Capalbo, Gaetano Palumbo, Giorgina Specchia, Cristiana Carniti, Paolo Corradini, Sara Pascale, Sabrina Coluzzi, Michele Pizzuti, Angela Amendola, Michele Cimminiello, Angela Matturro, Domenico Vertone, Nunzio Filardi, Attilio Olivieri
Journal: Blood (2012)
Satisfaction and Adherence Significantly Improves in Patients with β-Thalassemia and Myelodysplastic Syndromes Treated with Deferasirox (Exjade®)
Authors: John B Porter, Donald Bowden, Arnold Ganser, Gabor Domokos, Diana Rofail, Jean-François Baladi, Maria Domenica Cappellini
Journal: Blood (2008)
Disruption of the Bcr-Abl/Jak2/HSP90 Network Complex Leading to Induction of Apoptosis in Drug-Resistant CML Cells by a New Compound WP1193
Authors: Ajoy K. Samanta, Sandip N. Chakraborty, Susmita Samanta, Yan Wang, Xiaoping Sun, E. Schlette, Waldemar Priebe, Ralph B. Arlinghaus
Journal: Blood (2008)