tbuckley/cabot-search huggingface dataset:
Impact of EUS-FNA in the Management of Patients with Oesophageal Cancer
Authors: H Suzuki, M McKernan, A Crumley, M Stephen, R Stuart, A Stanley
Journal: Endoscopy (2006)

Background: Endoscopic ultrasound (EUS) increases the accuracy of T and N stages directing the patient to more appropriate therapy. EUS-FNA provides cytological evidence of malignancy and is superior to CT and standard EUS in assessing malignant nodes.
THU0370 Hip Fractures in Portugal: 2006-2010 an Epidemiologic Analysis
Authors: A. A. Marques, R. Ferreira, A. Mendes, Ó. Lourenço, V. Tavares, J. A. P. da Silva
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Hip fractures are considered to be the most devastating consequence of osteoporosis. They require long hospitalizations and high health-care costs and represent an important cause of morbidity, disability, and mortality, especially in the elderly<sup>1</sup>. As patients are invariably hospitalized in most countries the epidemiology of hip fracture is well documented compared with other fracture outcomes and provides a surrogate for the total burden of osteoporosis<sup>2</sup>. <h3>Objectives</h3> To carry out an epidemiologic analyses of hip fractures incidence rates in Portugal. <h3>Methods</h3> All cases of hip fracture occurred at 40 years of age or above from 2006 to 2010 were extracted from the Portuguese National Hospital Discharge Register. Age and gender-stratified population data was collected from the Institute for National Statistics. Average annual incidences were computed for age and gender groups along with the associated mortality, length of hospital stay and destination of the patient after discharge. Statistical differences between genders were assessed trough IBM SPSS® 20 with 0.05 as level of significance. <h3>Results</h3> A total of 51701 hip fractures occurred in the period under analysis. Hip fracture incidence rates were higher in women than in men and increased with age. The lowest incidence was observed in the 40-44 age group (14.1 and 4.0 per 100,000 inhabitants for men and women, respectively). The highest rate was observed among the 95-100 age-group (2,577.6 and3,551.8/100,000 inhabitants, for men and women, respectively). The mean length of hospital stay was13.4 days for men and 14.2 days for women (t<sub>(19271.4)</sub>=6.731; p&lt;0.05), respectively. We also found statistically significant differences between genders on patient's destination after discharge (Chi Square<sub>(5)</sub>=253.099; p&lt;0.05), the most frequent being: home 88.5% (men=85.3%; women=89.6%), mortality 5.1% (men=7.9%; women=4.3%), transferred for another hospital 3.9% (men=4.9%; women=3.7%), with homecare help 1.9% (men=1.2%; women=1.9%), discharge without medical consent 0.6%( men=0.7%; women=0.5%). <h3>Conclusions</h3> As expected women have a higher incidence of hip fractures. The Portuguese women are more likely to go home after being discharge of the hospital and have a lower mortality. Men are more likely to be transferred for another hospital. Further studies are necessary for access the mortality rates after discharge. <h3>References</h3> Kanis, J.A. &amp; Johnell, O. (2005). Requirements for DXA for the management of osteoporosis in Europe. <i>Osteoporos Int.,</i> 16:229–38. Cooper, C., Cole, Z.A., Holroyd, C.R., Earl, S.C., Harvey, N.C., Dennison, E.M., Melton, L.J., Cummings, S.R., &amp; Kanis, J.A. (2011). Secular trends in the incidence of hip and other osteoporotic fractures. <i>Osteoporos Int.,</i> 22:1277–88. <h3>Disclosure of Interest</h3> None Declared
Deep Brain Stimulation for Depression
Authors: Helen S. Mayberg, Patricio Riva-Posse, Andrea L. Crowell
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Relation of Fragmented QRS to Tissue Doppler-Derived Parameters in Patients with Familial Mediterranean Fever
Authors: Muhammet Murat Çelik, Eyüp Büyükkaya, Nilgül Üstün, Alper Buğra Nacar, Mustafa Kurt, Mehmet Fatih Karakaş, Perihan Bilen, Mehmet Duru, Nihat Şen, Adnan Burak Akçay
Journal: Journal of the American College of Cardiology (2013)
CHEMICAL DENERVATION OF THE RENAL ARTERY BY VINCRISTINE: THE ROLE OF THE DELIVERY FLOW RATE
Authors: Andreas Synetos, Konstantinos Toutouzas, Georgios Benetos, Konstantinos Stathogiannis, George Trantalis, George Agrogiannis, Christodoulos Stefanadis, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2015)
Survey of Blood Collection Centers and Implementation of Guidance for Prevention of Transfusion-Transmitted Zika Virus Infection — Puerto Rico, 2016
Authors: Amber M. Vasquez, Mathew R.P. Sapiano, Sridhar V. Basavaraju, Matthew J. Kuehnert, Brenda Rivera-Garcia
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Since November 2015, Puerto Rico has reported active mosquito-borne transmission of Zika virus. Because of the potential for Zika virus to be transmitted through transfusion of blood components, and because a high percentage of persons infected with Zika virus are asymptomatic, the Food and Drug Administration (FDA) recommended that blood collections cease in areas of the United States affected by active vector-borne transmission of Zika virus until laboratory screening of blood donations or pathogen reduction technology (PRT) for treatment of blood components can be implemented. To inform efforts to maintain the safety and availability of the blood supply in Puerto Rico, CDC, in collaboration with the Puerto Rico Department of Health, conducted a rapid assessment of blood collection and use on the island. A total of 139,369 allogeneic red blood cell (RBC) units, 45,243 platelet units, and 56,466 plasma units were collected in or imported to Puerto Rico during 2015, and 135,966 allogeneic RBC units, 13,526 therapeutic platelet units, and 25,775 plasma units were transfused. Because of the potential for local Zika virus transmission in areas with a competent mosquito vector, other areas of the United States should develop plans to ensure local blood safety and adequacy. Blood collection organizations and public health agencies should collaborate to maintain the safety and availability of local blood supplies in accordance with FDA guidance.
Language Mapping in Pretreatment Planning of Patients with Cerebral Arteriovenous Malformation
Authors: R Tatlidil, J Xiong, P New, A West, P Fox
Journal: Clinical Nuclear Medicine (2000)

Purpose Three patients who had cerebral arteriovenous malformations underwent language mapping by positron emission tomography (PET) to identify the dominant hemisphere for language and the spatial relation of lesions to language areas. Methods Mapping was performed to assess the risk that surgery could cause neurologic deficits and to plan other therapeutic strategies. Results The information obtained by PET language mapping changed the course of management for these patients. Two patients were treated with stereotactic radiosurgery and one patient with surgical resection. Conclusions PET imaging can be a valuable noninvasive tool for mapping the functional cortex and for preoperative planning of different treatment options in patients with arteriovenous malformations.
Abstract LB-132: Protein interactome between PTEN and cancer-associated mutant demonstrated the regulatory pathway of migration through its novel interactors
Authors: Mei Xian Goh, Jayantha Gunaratne, Lee Foon Swa, Emma M. Sanford, Fen Yee Lee, Kelly A. Hogue, Walter Blackstock, Koichi Okumura
Journal: Cancer Research (2011)

Abstract Mutation of the PTEN tumor suppressor protein frequently occurs in a variety of human cancers. PTEN is a phosphatase that negatively regulates the phosphatidyl-inositol-3-kinase (PI3K) pathway, and regulates cell proliferation, apoptosis, and cell motility. Though the tumor suppressive function involves PTEN's lipid phosphatase-dependent and -independent activities, the mechanism leading to the phosphatase-independent function of PTEN is poorly understood. Some PTEN mutants have lipid phosphatase activity but fail to suppress cell growth. Here we use a cancer associated mutant, G20E, to gain insight into the phosphatase-independent function of PTEN by investigating protein-protein interactions using mass spectrometry (MS)-based stable isotope labeling by amino acids in cell culture (SILAC). A strategy named parallel affinity purification (PAP) and SILAC has been developed to prioritize interactors and to compare the interactions between wild-type and G20E PTEN. Clustering of the prioritized interactors acquired by the PAP-SILAC approach are mainly involved in cell migration and apoptosis pathways, suggesting deregulation of the pathways could be involved in the tumorigenesis derived by the PTEN mutant. We further demonstrate that the one of wild-type specific interactor is required for the regulatory function of wild-type PTEN in cell migration. Furthermore, the other wild type specific interactor affects cell growth. These finding contribute to a better understanding of the mechanisms of PTEN's functions. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-132. doi:10.1158/1538-7445.AM2011-LB-132
CHANGES IN MITRAL ANNULAR GEOMETRY AND CARDIAC FUNCTION AFTER TRANSAPICAL OFF-PUMP MITRAL VALVE REPAIR WITH NEOCHORD IMPLANTATION
Authors: Andrea Colli, Erica Manzan, Fabio Zucchetta, Eleonora Bizzotto, Laura Besola, Cristiano Sarais, Demetrio Pittarello, Roberto Bellu, Gino Gerosa
Journal: Journal of the American College of Cardiology (2015)
801 LONG-TERM EVOLUTION OF LIVER FIBROSIS IN MILD–MODERATE CHRONIC HEPATITIS C: STUDY WITH PAIRED BIOPSIES
Authors: N. Cañete, M. García, I. Ojanguren, I. Cirera, M. Garcia- Retortillo, J.A. Carrión, M. Puigvehí, M.D. Giménez, C. Márquez, S. Coll, F. Bory, R. Solà
Journal: Journal of Hepatology (2013)
Use of Cocaine during Pregnancy
Authors: Eduard Gratacos, Pere Joan Torres, Eugenia Antolin
Journal: New England Journal of Medicine (1993)

To the Editor: Exposure of the fetus to cocaine may lead to serious destructive lesions in the brain1–3. Results of brain imaging studies in newborns have revealed that ischemic cerebral lesions may occur, leading to clinical manifestations when large. Fetal death in women using cocaine during pregnancy has been most frequently related to abruptio placentae. We report a case of fetal death with generalized cerebral ischemia and necrosis that was probably related to maternal abuse of cocaine in late pregnancy. A 28-year-old woman with a history of cocaine abuse became pregnant in February 1992 and was followed at . . .
IMPACT OF STENT DIAMETER ON STENT PATENCY AFTER SELF-EXPANDING PACLITAXEL-ELUTING STENT IMPLANTATION IN THE SUPERFICIAL FEMORAL ARTERY: AN INTERIM REPORT
Authors: Kojiro Miki, Kenichi Fujii, Tetsuo Horimatsu, Takumi Kimura, Kozo Okada, Tohru Masuyama, Masaharu Ishihara, Peter Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2016)
SAT0042 Low-Density Lipoprotein Cholesterolemia as a Novel Risk Factor for Radiographic Progression of Rheumatoid Arthritis: A Single Centered Prospective Study
Authors: Y.-J. Park, C.-S. Cho, P. Emery, W.-U. Kim
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Dyslipidemia has been implicated in a variety of musculoskeletal disease including rheumatoid arthritis (RA). Evidence is emerging that there might be a pathogenic interaction among inflammation, dyslipidemia, and adipokines. <h3>Objectives</h3> We prospectively investigated the association of cumulative lipid levels with radiographic progression. <h3>Methods</h3> Two hundred-forty two RA patients regularly underwent plasma cholesterol assessment at four-time visits. Disease activity parameters, including ESR, CRP, DAS28, and hands/feet X-rays were also serially monitored in these patients. The cumulative inflammatory burden and lipid levels were estimated by the time-integrated value. Serum leptin and adiponectin concentrations were determined by ELISA. <h3>Results</h3> When patients were divided into three groups according to time-integrated lipid levels, 3<sup>rd</sup> tertile of LDL cholesterol and/or triglyceride had persistently higher ESR and CRP levels. In parallel, a more rapid radiographic progression over 2 years was observed in patients with higher LDL cholesterol and/or triglyceride. In multivariate analysis, time-integrated LDL cholesterol was independently associated with the radiographic progression after adjustments for potential confounders. Particularly, the risk of radiographic progression was 5.6-fold in a subgroup with both 3<sup>rd</sup> tertiles of LDL cholesterol and triglyceride. Moreover, LDL cholesterol synergistically increased the adjusted probability of radiographic progression in patients with high serum leptin levels, but not in those without. <h3>Conclusions</h3> Our data demonstrate that LDL cholesterolemia is a novel serum marker to predict radiographic progression of RA, which seems to be related to circulatory leptin levels. We suggest that a personalized and more aggressive anti-rheumatic therapy is required for dyslipidemic subgroups in RA patients. <h3>Disclosure of Interest</h3> None Declared
Abstract 1960: Transgenic overexpression of Cdx1b in zebrafish induces metaplastic changes of gene expression in the squamous epithelium
Authors: Bo Hu, Xiuping Liu, Gregory Cole, Chengjin Zhang, Ju-Ahng Lee, Xiaoxin (Luke) Chen
Journal: Cancer Research (2010)

Abstract Background and aims: Cdx2 has been suggested to play an important role in Barrett's esophagus (BE), or intestinal metaplasia (IM) in the esophagus. However, it is still unclear whether ectopic overexpression of Cdx2 may lead to IM in the esophagus in vivo. The aim of the present study was to investigate whether transgenic overexpression of Cdx1b, the functional equivalent of mammalian Cdx2 in zebrafish, may lead to IM of squamous epithelium in zebrafish. Methods: We first characterized the histology of the upper gastrointestinal tract of zebrafish. A highly conserved promoter of zebrafish keratin 5 was cloned to drive transgenic expression of GFP. A transgenic zebrafish system was then developed by expressing Cdx1b gene under the control of zebrafish keratin 5 promoter (zK5p). Cdx1b expression in the squamous epithelium of transgenic zebrafish was analyzed by in situ hybridization, immunohistochemical staining and RT-PCR. Gene expression in the squamous epithelium of wild-type and transgenic zebrafish was analyzed by Affymetrix microarray and confirmed by in situ hybridization. Morphology, mucin expression, cell proliferation and apoptosis were analyzed by H&amp;E staining, PAS Alcian blue staining, PCNA immunohistochemical staining and TUNEL assay as well. Results: We found that zebrafish tongue was covered by a non-keratinized stratified squamous epithelium, which was similar to the oro-esophageal epithelium in humans. In situ hybridization showed that keratin 5, a marker of the basal cell layer of mammalian esophageal epithelium, was expressed in the squamous epithelium of zebrafish tongue. GFP expression in transgenic fish recapitulated endogenous zebrafish keratin 5 gene expression as shown by in situ hybridization. In Cdx1b transgenic zebrafish, Cdx1b was found to be overexpressed in the nuclei of squamous epithelial cells of the transgenic zebrafish. Cdx1b induced metaplastic changes in gene expression in the squamous epithelial cells, that is, up-regulation of intestinal differentiation markers and down-regulation of squamous differentiation markers. However, Cdx1b did not induce histological IM, or modulate cell proliferation and apoptosis in the squamous epithelium of transgenic zebrafish. Conclusion: Transgenic overexpression of Cdx1b in the squamous epithelial cells induced metaplastic changes in gene expression, but failed to produce metaplastic changes in morphology. Cdx1b/Cdx2 may require cooperation of other genetic factors for induction of IM in squamous epithelium. In the present study, we first characterized the histology of the upper gastrointestinal tract of zebrafish. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1960.
PWE-092 Will the national awareness and early diagnosis initiative (NAEDI) have an impact on bowel cancer screening activity?
Authors: J Snowball, M Young, S Halloran
Journal: Gut (2012)

<h3>Introduction</h3> 1- and 5-year survival from all cancers in England is poorer than for other comparable countries, largely because of delayed diagnosis. The UK9s Department of Health has estimated that if cancer survival in England could be improved to match the best in Europe, then 10 000 lives would be saved every year, about 1700 of which would be from bowel cancer. The National Awareness and Early Diagnosis Initiative (NAEDI) is a Government plan to raise public awareness of the early signs and symptoms of cancer and, as one of the leading causes of cancer death, bowel cancer has been identified as a particular target. During 7 weeks in early 2011, a pilot bowel cancer NAEDI campaign was run in two Strategic Health Authorities (SHAs), including the South West SHA, with widespread coverage on local television, radio and newspapers and distribution of educational literature to general practitioners (GPs). The public was urged to consult their GP if they had any symptoms of bowel cancer and, consequently, attendance with relevant symptoms at GP practices increased by 48% with a 32% increase in 2-week wait referrals. Little direct reference was made to the Bowel Cancer Screening Programme (BCSP). <h3>Methods</h3> The BCSP Southern Hub has analysed screening data for the South West SHA to explore the indirect effects of the pilot campaign on screening activity. Screening data for the general practices covered by the media campaign were compared with data for the same practices a year earlier and with data for practices served by the Southern Hub not targeted during the campaign period at that time and a year earlier. <h3>Results</h3> There was a small increase in overall uptake among individuals who were participating for the first time, but no evidence of a change in uptake by individuals who had previously participated in the Screening Programme. The Hub saw no increase in the number of calls received by the Helpline, test kits were not returned any more quickly and there was no change in the proportion of positive test kits. Comparisons drawn between the practices described are limited, however, by the likelihood that publicity reached areas not targeted for media coverage, the pilot campaign ran after Christmas when fluctuations in screening activity are considerable and age-extension was underway in some areas. <h3>Conclusion</h3> At the end of January 2012, the Government launched a 9-week national bowel cancer awareness campaign. Providers have been urged to plan for a 50% increase in GP referrals during the campaign and for a sustained increase in colonoscopy demand over the next 5 years. This analysis of local screening activity during the pilot campaign, however, suggests that the direct effect of the national NAEDI campaign on bowel cancer screening hub activity is likely to be modest. <h3>Competing interests</h3> None declared.
P14.02 * ESTABLISHMENT OF COMPUTERIZED HOSPITAL-BASED CANCER REGISTRY IN THE CLINICAL ONCOLOGY DEPARTMENT OF AIN SHAMS UNIVERSITY HOSPITALS IN EGYPT: OUTLOOK ON CNS TUMORS
Authors: W. A. Anwar, H. I. Fahim, D. G. Sos, A. S. Ibrahim, Z. M. Abdel Hafeez, R. R. Ghali
Journal: Neuro-Oncology (2014)

BACKGROUND: Hospital-based registry plays an important role in providing statistics regarding the occurrence of cancer in a defined population and a framework for assessing and controlling the impact of cancer in the community. Central nervous system (CNS) tumors represent a major public health problem, and their epidemiological data in Egypt have been rather incomplete except for some regional reports. The objective of this study was to set up a model of cancer registry form to be used in the establishment of a computerized hospital-based registry system and provide hospital-based data of cancer cases for a whole year and to use the National Cancer Registry Program of Egypt (NCRPE) to estimate the incidence of CNS tumors. METHODOLOGY: We introduced the software program of National Cancer Registry Program of Egypt (NCRPE) in the Clinical Oncology department of Ain Shams University Hospitals. All newly diagnosed cases with CNS tumors have been registered from 30 May 2012 to 1st June 2013 using the NCRPE registry form followed by its entry in the software program. RESULTS:The software program of the NCRPE was introduced in the Clinical Oncology department which is a web-based application developed by the registry and centrally stored on the main server of the ministry of Communication and Information Technology. “Double Minus” program was developed to detect duplicate cases to complete the data processing cycle. Duplicate forms were shown on the screen for the data manager to complete one form and discard the other or include the 2nd form as double primary with adjustment of sequence number. The program store all data entered allows exporting the data at any time into an excel file in a way that facilitate direct analysis of the data for research purposes. The total number of registered newly diagnosed patients received during the study period was 943 cases. CNS tumors accounted for 53 newly diagnosed cases(5.6%)and was ranked as the fourth common cancer in both sexes. 54.7% of CNS tumors occurred in males . The mean age was 43.1 years +/- 19.5 SD. 62.3% of the cases were from Cairo, 20.8% were from Upper Egypt and 8% were from Lower Egypt. 54% of the lesions were overlapping and 13% of the cases were presented with frontal lobe lesions at time of diagnosis. Glioblastoma Multiforme was the most common pathology occurring in about 43.3% of the presented cases. CONCLUSION: Hospital-based cancer registry is a corner stone for cancer burden assessment through providing accurate incidence data.This study drew attention to the incidence of the CNS tumors that requires further epidemiological studies for possible risk factors association.