tbuckley/cabot-search huggingface dataset:
Clinical Experiences with Streptokinase as Thrombolytic Agent
Authors: M VERSTRAETE, A AMERY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CSF cholecystokinin octapeptide in patients with bulimia nervosa and in normal comparison subjects
Authors: R B Lydiard, T D Brewerton, M D Fossey, M T Laraia, G Stuart, M C Beinfeld, J C Ballenger
Journal: American Journal of Psychiatry (1993)

Cholecystokinin octapeptide (CCK-8) appears to modulate appetitive behavior, and in rodents, anxiety-related behavior. The authors studied CCK-8 in patients with bulimia nervosa. CSF concentrations of CCK-8 were measured in 11 drug-free female patients with DSM-III-R-defined bulimia nervosa and in 16 normal subjects. The bulimic patients had significantly lower levels of CCK-8 than the comparison subjects. CCK-8 concentrations were inversely correlated with scores on the anger-hostility, anxiety, and interpersonal sensitivity subscales of the SCL-90-R. They were not significantly correlated with age, percentage of standardized average body weight, or mean weekly frequency of binge eating or vomiting. The results indicate that central CCK-8 abnormalities may play a role in the pathophysiology of bulimia nervosa.
Hemolytic Anemia
Authors: James H. Jandl
Journal: New England Journal of Medicine (1963)

IF one defines hemolytic anemias as those in which the life-span of the red cell is diminished, most anemias are hemolytic. Practically, however, it is useful to confine the term to anemias in which shortening of the red-cell life-span is the principal cause of the anemia. The rate of red-cell destruction in such anemias ordinarily exceeds twice the normal and may be ten or twelve times the normal rate. When this rate exceeds the compensatory efforts of the bone marrow anemia ensues. Accordingly, therapy is directed toward restoring the equilibrium between the rates of destruction and production, either by slowing . . .
HG-77RADIATION-INDUCED HIGH GRADE GLIOMA FOLLOWING I-125 BRACHYTHERAPY IN A PEDIATRIC PATIENT
Authors: Daniela Garcez, Eduardo Netto, Duarte Salgado
Journal: Neuro-Oncology (2016)

HG-77. RADIATION-INDUCED HIGH GRADE GLIOMA FOLLOWING I-125 BRACHYTHERAPY IN A PEDIATRIC PATIENT Daniela Garcez, Eduardo Netto, and Duarte Salgado; Instituto Portugues de Oncologia de Lisboa Francisco Gentil E.P.E., Lisboa, Portugal INTRODUCTION: Brachytherapy has been used in brain tumors since 1960. Only a few studies have been published about late occurence of second malignancies due to brachytherapy for brain tumors. Therefore, this procedureappears to be an attractive alternative in multimodality cancer management in selected pediatric cases. CASE PRESENTATION: We report the case of a 33 years old female patient diagnosed with an anaplastic ependymoma grade III (right frontal lobe) when she was 8 years old. After a total resection she underwent craniospinal radiotherapy (36Gy) with a focal boost (54Gy). A local relapse was identified three years later and pathological diagnosis, after total resection, was ependymoblastoma. She received I-125 brachytherapy for 3 months followed by 8 cycles of CCNU, cisplatin and vincristine. She remained in total remission for almost 20 years. In 2015 she was admitted due to progressive apathy. An MRI scan showed a large contrast enhancing tumor (8x7cm) in the right frontal lobewith mass effect and midline shift. After subtotal resection the pathological diagnosis was anaplastic oligodendroglioma. CONCLUSION: Despite the obvious advantages that I-125 brachytherapy presents, the use in the pediatric population remains controversial.Radiation-induced tumors area serious issue andareusuallyagressiveand sometimes fatal. The enhanced risk of associating standard external beam radiotherapy with brachytherapy should be carefully considered in the pediatric population. Neuro-Oncology 18:iii48–iii77, 2016. doi:10.1093/neuonc/now073.73 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Domiciliary Treatment of Tuberculosis.
Authors: G F Kincade
Journal: JAMA (1922)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells
Authors: Florian Grahammer, Suresh K. Ramakrishnan, Markus M. Rinschen, Alexey A. Larionov, Maryam Syed, Hazim Khatib, Malte Roerden, Jörn Oliver Sass, Martin Helmstaedter, Dorothea Osenberg, Lucas Kühne, Oliver Kretz, Nicola Wanner, Francois Jouret, Thomas Benzing, Ferruh Artunc, Tobias B. Huber, Franziska Theilig
Journal: Journal of the American Society of Nephrology (2016)

Renal proximal tubular cells constantly recycle nutrients to ensure minimal loss of vital substrates into the urine. Although most of the transport mechanisms have been discovered at the molecular level, little is known about the factors regulating these processes. Here, we show that mTORC1 and mTORC2 specifically and synergistically regulate PTC endocytosis and transport processes. Using a conditional mouse genetic approach to disable nonredundant subunits of mTORC1, mTORC2, or both, we showed that mice lacking mTORC1 or mTORC1/mTORC2 but not mTORC2 alone develop a Fanconi-like syndrome of glucosuria, phosphaturia, aminoaciduria, low molecular weight proteinuria, and albuminuria. Interestingly, proteomics and phosphoproteomics of freshly isolated kidney cortex identified either reduced expression or loss of phosphorylation at critical residues of different classes of specific transport proteins. Functionally, this resulted in reduced nutrient transport and a profound perturbation of the endocytic machinery, despite preserved absolute expression of the main scavenger receptors, MEGALIN and CUBILIN. Our findings highlight a novel mTOR-dependent regulatory network for nutrient transport in renal proximal tubular cells.
HG-19COMBINED TARGETING OF MITOCHONDRIAL FUNCTION AND mTOR IS A POTENT NOVEL THERAPEUTIC APPROACH FOR DIFFUSE INTRINSIC PONTINE GLIOMA
Authors: Maria Tsoli, Cecilia Chang, Han Shen, Jie Liu, Arjanna Chintranjan, Laura Franshaw, Pierre Dilda, Angel Montero Carcaboso, Phil Hogg, David Ziegler
Journal: Neuro-Oncology (2016)
Virus of Avian Erythroblastosis. V. Adenosinetriphosphatase Activity of Blood Plasma from Chickens with the Disease&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: R. A. Bonar, G. S. Beaudreau, D. G. Sharp, D. Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Virus of Avian Erythroblastosis. V. Adenosinetriphosphatase Activity of Blood Plasma from Chickens with the Disease Get access R. A. Bonar, R. A. Bonar Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar G. S. Beaudreau, G. S. Beaudreau Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar D. G. Sharp, D. G. Sharp Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar D. Beard, D. Beard Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Beard J. W. Beard Department of Surgery, Duke University School of Medicine, Durham, North Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 5, November 1957, Pages 909–922, https://doi.org/10.1093/jnci/19.5.909 Published: 01 November 1957 Article history Received: 27 May 1957 Published: 01 November 1957
QOS-46PERIODIC ASSESSMENT WITH OPTICAL COHERENCE TOMOGRAPHY IN CHILDREN TREATED WITH MULTIMODAL THERAPIES FOR BRAIN TUMORS
Authors: Giacomo Bacci, Martina Ghin, Maurizio Lucchesi, Milena Guidi, Maria Concetta Ferraro, Lorenzo Genitori, Roberto Caputo, Iacopo Sardi
Journal: Neuro-Oncology (2016)
Use of tumor exome analysis to reveal neo-antigen-specific T-cell reactivity in ipilimumab-responsive melanoma.
Authors: Nienke van Rooij, John B. A. G. Haanen, Marit van Buren, Daisy Philips, Mireille Toebes, Bianca Heemskerk, Laura van Dijk, Sam Behjati, Michael R. Stratton, Ron M Kerkhoven, Can Kesmir, Pia Kvistborg, Ton Schumacher
Journal: Journal of Clinical Oncology (2013)

9085 Background: Evidence for T cell mediated regression of human cancer in particular melanoma following immunotherapy is strong. Anti-CTLA4 treatment has been approved for treatment of metastatic melanoma and blockade of PD-1 has shown encouraging results. However, it is unknown which T cell reactivities are involved in cancer regression. Reactivity against non-mutated tumor self-antigens has been analyzed in patients treated with Ipilimumab or with autologous TILs, but the size of these responses are modest. Therefore, T cell recognition of patient-specific mutant epitopes may be a potentially important component. Animal model data recently suggested that analysis of T cell reactivity against patient-specific neo-antigens may be feasible through exploitation of cancer genome data. However, human data have thus far been lacking. Methods: To address this we have used MHC class I peptide exchange technology allowing production of very large collections of pMHC complexes, together with a pMHC "combinatorial coding" strategy for parallel detection of dozens of different T cell populations within a single sample. Results: From a melanoma patient responding to ipilimumab treatment, we identified tumor specific mutations via exome sequencing of tumor material. The exome contained 1,075 non-synonymous mutations. Possible MHC epitopes covering these mutations were predicted based on; 1) predicted to bind the patient’s MHC; 2) predicted to be cleaved by the proteasome; 3) genes of which the mutated peptides arose had evidence of RNA expression. The analysis yielded 1,952 epitopes restricted to the HLA-A and HLA-B. To screen for T cell reactivity against these epitopes we used the pMHC combinatorial coding approach. We found T cell reactivity against 2 neo-antigens, including a dominant T cell response against a mutant epitope of the ATR gene product. Analysis of PBMC samples collected before and during Ipilimumab therapy showed that this particular response increased strongly after treatment from 0.06% to 0.28% of CD8 T cells after being stable in magnitude for 10 months. Conclusions: These data provide the first demonstration of cancer exome-guided analysis to dissect the effects of melanoma immunotherapy.
Acute nonlymphocytic leukemia after radiation and MOPP chemotherapy for Hodgkin's disease.
Authors: R S Lavey
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.12.2089 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2230901 Acute nonlymphocytic leukemia after radiation and MOPP chemotherapy for Hodgkin's disease. R S LaveyxR S LaveySearch for articles by this author https://doi.org/10.1200/JCO.1990.8.12.2089 PDF "Acute nonlymphocytic leukemia after radiation and MOPP chemotherapy for Hodgkin's disease.." Journal of Clinical Oncology, 8(12), pp. 2089–2090© 1990 by American Society of Clinical Oncology
A psychodynamically oriented group training program for early childhood care givers
Authors: S I Greenspan, B Silver, M G Allen
Journal: American Journal of Psychiatry (1977)

A training program for enhancing the care-giving qualities of child-care workers was developed and implemented through semistructured groups for family day-care mothers. The authors describe the theoretical orientation, program goals, and the outcome for trainees and trainers. Most impressive was the group process and content, which indicated the effectiveness of psychodynamically oriented program for care givers--people who ordinarly would not be expected to integrate such an experience successfully.
Le silence
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
On the Development of Leukemia in Four Low-Leukemic Strains of Mice Following Injection of a Small Dose of 9,10-Dimethyl-1,2-Benzanthracene into the Thymus<xref ref-type="fn" rid="fn1">2</xref>
Authors: R RASK-NIELSEN
Journal: JNCI Journal of the National Cancer Institute (1956)
Poor CMV-specific CD8+ T central memory subset recovery at early stage post-HSCT associates with refractory and recurrent CMV reactivation
Authors: Jing Liu, Ying-Jun Chang, Chen-Hua Yan, Lan-Ping Xu, Zheng-Fan Jiang, Xiao-Hui Zhang, Kai-Yan Liu, Xiao-Jun Huang
Journal: Journal of Infection (2016)
LG-48PAEDIATRIC LOW GRADE GLIOMAS - IMPACT OF GROSS TOTAL RESECTION IN A SINGLE CENTRE COHORT
Authors: Noelle Cullinan, John Caird, Michael Capra, Jane Pears, Cormac Owens, Darach Crimmins
Journal: Neuro-Oncology (2016)

LG-48. PAEDIATRIC LOW GRADE GLIOMAS IMPACT OF GROSS TOTAL RESECTION IN A SINGLE CENTRE COHORT Noelle Cullinan1, John Caird2, Michael Capra1, Jane Pears1, Cormac Owens1, andDarachCrimmins2; DepartmentofHaematology/Oncology,Our Lady’s Children’s Hospital, Dublin, Ireland; Department of Paediatric Neurosurgery, Children’s University Hospital, Temple Street, and Beaumont Hospital, Dublin, Ireland AIMS: Completely excised paediatric low grade gliomas (LGGs) are associated with excellent survival rates. Complete resection is not always achievable. We reviewed the Irish neurosurgical experience of paediatric LGGs over a 10-year period. METHODS: We performed a retrospective review of all paediatric patients with LGG diagnosed in the Republic of Ireland between 2005-2014. RESULTS: 112 children were diagnosed over a 10-year period (52 male (46%), 60 female (53%), Age range 0.23–15.87 years, Mean 7.03 years, Median 6.3 years). 111 children had surgical procedures – 14 (13%) had biopsies alone, 16 (14%) had biopsies followed by later resections, while 79 (71%) had upfront craniotomies with resection. We were unable to identify the type of procedure in 2 children. 1 child had a radiological diagnosis of aLGG but no confirmatorybiopsy.79 patientshadupfront craniotomies. In 77/79, all required information was available. 40/77 (52%) had Gross Total Resection (GTR) confirmed by post-operative imaging and 37/77 (48%) had incomplete resections. Of those who had GTR confirmed (excluding patients with Neurofibromatosis Type 1), 3 patients (4%) relapsed or had disease progression in follow-up, with early progression noted, all within 15 months after resection. All others are currently disease free in follow up (96%). CONCLUSION: In those with confirmed GTR on post-operative imaging, recurrence, if it occurred, was early. We propose that scanning intervals can be increased after 2 years and ongoing need for imaging surveillance in those with confirmed GTR should be reviewed. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.48 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Psychosis as a transdiagnostic and extended phenotype in the general population
Authors: Jim van Os, Uli Reininghaus
Journal: World Psychiatry (2016)

A large body of research indicates that weak expressions of positive psychotic symptoms (“psychotic experiences”) can be measured in the general population, and likely represent the behavioural manifestation of distributed multifactorial (genetic and non‐genetic) risk for psychosis. Psychotic experiences are a transdiagnostic phenomenon: the majority of individuals with these experiences have a diagnosis of non‐psychotic disorder, particularly common mental disorder, in which psychotic experiences predict greater illness severity and poorer treatment response. Some of the people with common mental disorder and psychotic experiences will present to mental health services meeting criteria for “clinical high risk”. Treatment of the transdiagnostic dimension of psychosis in individuals with common mental disorder who meet “clinical high risk” criteria thus may improve outcome (which cannot be interpreted as prevention of “schizophrenia”). Subthreshold psychotic experiences are transitory in about 80% of individuals, while around 20% go on to develop persistent psychotic experiences and 7% a psychotic disorder, with an annual transition rate of 0.5‐1%. Persistence is associated, on the one hand, with environmental exposures, particularly childhood trauma, and, on the other, with network‐type dynamic interactions between psychotic experiences themselves (e.g., interactions between hallucinatory experiences and delusional ideation) and between symptom dimensions (e.g., interactions between affective symptoms and psychotic experiences, or interactions between subthreshold negative symptoms and psychotic experiences). The study of psychotic experiences is helping to elucidate the mechanisms by which environmental and genetic influences shape the transdiagnostic expression of psychosis proneness, that is mostly transitory but may first become persistent over time and eventually give rise to transition to a psychotic disorder.
Outbreak of tinea corporis gladiatorum, a fungal skin infection due to Trichophyton tonsurans, in a French high level judo team
Authors: D. M. Poisson, Didier Rousseau, D Defo, E Estève
Journal: Eurosurveillance (2005)

An outbreak of 49 cases of tinea corporis gladiatorum due to Trichophyton tonsurans infection occurred in a high level judo team of 131 members in Orléans, central France, between October 2004 and April 2005. The team was divided into 5 groups: cadet-junior boys (n=44), cadet-junior girls (n=33), male university students (n= 15), female university students (n=21), and a group called ‘pôle technique’ made up of high level judokas who have finished academic study (n=18). The outbreak involved 86% of the cadet-junior boys, but only 6 men in the ‘pôle technique’ (33%) and only 5 of the 69 other team members (7%) (cadet-junior girls and university students). We describe the outbreak and the results of a survey that found a known risk factor for the ‘pôle technique’: sharing an electric hair shaver. Personal hygiene practices were found to be very good among the cadet-junior boys. The high attack rate in this group may be linked to the poor shower facilities in the gymnasium where they practiced that led them to have their showers several hours after the end of daily practice.
Central venous pressure
Authors: A Church, R Valerón
Journal: JAMA (1967)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal