tbuckley/cabot-search huggingface dataset:
Effect of specific exercise-based football injury prevention programmes on the overall injury rate in football: a systematic review and meta-analysis of the FIFA 11 and 11+ programmes
Authors: Kristian Thorborg, Kasper Kühn Krommes, Ernest Esteve, Mikkel Bek Clausen, Else Marie Bartels, Michael Skovdal Rathleff
Journal: British Journal of Sports Medicine (2017)

Objective To investigate the effect of FIFA injury prevention programmes in football (FIFA 11 and FIFA 11+). Design Systematic review and meta-analysis. Eligibility criteria for selecting studies Randomised controlled trials comparing the FIFA injury prevention programmes with a control (no or sham intervention) among football players. Data sources MEDLINE via PubMed, EMBASE via OVID, CINAHL via Ebsco, Web of Science, SportDiscus and Cochrane Central Register of Controlled Trials, from 2004 to 14 March 2016. Results 6 cluster-randomised controlled trials had assessed the effect of FIFA injury prevention programmes compared with controls on the overall football injury incidence in recreational/subelite football. These studies included 2 specific exercise-based injury prevention programmes: FIFA 11 (2 studies) and FIFA 11+ (4 studies). The primary analysis showed a reduction in the overall injury risk ratio of 0.75 (95% CI 0.57 to 0.98), p=0.04, in favour of the FIFA injury prevention programmes. Secondary analyses revealed that when pooling the 4 studies applying the FIFA 11+ prevention programme, a reduction in the overall injury risk ratio (incidence rate ratio (IRR) 0.61; 95% CI 0.48 to 0.77, p&lt;0.001) was present in favour of the FIFA 11+ prevention programme. No reduction was present when pooling the 2 studies including the FIFA 11 prevention programme (IRR 0.99; 95% CI 0.80 to 1.23, p=0.940). Conclusions An injury-preventing effect of the FIFA injury prevention programmes compared with controls was shown in football. This effect was induced by the FIFA 11+ prevention programme which has a substantial injury-preventing effect by reducing football injuries by 39%, whereas a preventive effect of the FIFA 11 prevention programme could not be documented. Trial registration number PROSPERO CRD42015024120.
Genome‐Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry
Authors: Kimberly E. Taylor, Quenna Wong, David M. Levine, Caitlin McHugh, Cathy Laurie, Kimberly Doheny, Mi Y. Lam, Alan N. Baer, Stephen Challacombe, Hector Lanfranchi, Morten Schiødt, M. Srinivasan, Hisanori Umehara, Frederick B. Vivino, Yan Zhao, Stephen C. Shiboski, Troy E. Daniels, John S. Greenspan, Caroline H. Shiboski, Lindsey A. Criswell
Journal: Arthritis & Rheumatology (2017)

Objective The Sjögren's International Collaborative Clinical Alliance (SICCA) is an international data registry and biorepository derived from a multisite observational study of participants in whom genotyping was performed on the Omni2.5M platform and who had undergone deep phenotyping using common protocol‐directed methods. The aim of this study was to examine the genetic etiology of Sjögren's syndrome (SS) across ancestry and disease subsets. Methods We performed genome‐wide association study analyses using SICCA subjects and external controls obtained from dbGaP data sets, one using all participants (1,405 cases, 1,622 SICCA controls, and 3,125 external controls), one using European participants (585, 966, and 580, respectively), and one using Asian participants (460, 224, and 901, respectively) with ancestry adjustments via principal components analyses. We also investigated whether subphenotype distributions differ by ethnicity, and whether this contributes to the heterogeneity of genetic associations. Results We observed significant associations in established regions of the major histocompatibility complex (MHC), IRF5 , and STAT4 ( P = 3 × 10 −42 , P = 3 × 10 −14 , and P = 9 × 10 −10 , respectively), and several novel suggestive regions (those with 2 or more associations at P &lt; 1 × 10 −5 ). Two regions have been previously implicated in autoimmune disease: KLRG1 ( P = 6 × 10 −7 [Asian cluster]) and SH2D2A ( P = 2 × 10 −6 [all participants]). We observed striking differences between the associations in Europeans and Asians, with high heterogeneity especially in the MHC; representative single‐nucleotide polymorphisms from established and suggestive regions had highly significant differences in the allele frequencies in the study populations. We showed that SSA/SSB autoantibody production and the labial salivary gland focus score criteria were associated with the first worldwide principal component, indicative of higher non‐European ancestry ( P = 4 × 10 −15 and P = 4 × 10 −5 , respectively), but that subphenotype differences did not explain most of the ancestry differences in genetic associations. Conclusion Genetic associations with SS differ markedly according to ancestry; however, this is not explained by differences in subphenotypes.
Tissue Factor-Dependent Pro-Coagulant Activity Of Human Platelets Is Directly Related To Membrane Cholesterol Content. Rosuvastatin, But Not Atorvastatin, Reduces The Platelet Cholesterol, Tissue Factor Protein and Clotting Activity In Hypercholesterolemic Patients
Authors: Olga Panes, Juan P. Valderas, Mónica Acevedo, Susana Contreras, Jaime Pereira, Attilio Rigotti, Diego Mezzano
Journal: Blood (2013)
SELDI-TOF-Based Proteomic Analysis of Plasma Samples as a Diagnostic Tool to Predict Acute Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation
Authors: Vanessa Wittke, Harald Binder, Stefan Zimmermann, Dietmar Pfeifer, Martin Schumacher, Juergen Finke, Hendrik Veelken
Journal: Blood (2008)
Allogeneic Stem Cell Transplantation for CML in Second Chronic Phase After Blast Crisis in the Tyrosine Kinase Inhibitor Era
Authors: Sairah Ahmed, Alexandre Chiattone, Roy Jones, Elizabeth J Sphall, Shatha Farhan, Gabriela Rondon, Yago Nieto, Qaiser Bashir, Julienne Chen, Issa F. Khouri, Partow Kebriaei, Paolo Anderlini, Richard Champlin, Marcos De Lima
Journal: Blood (2011)
Clinical Relevance of Spontaneous Apoptosis Is Independent from Multidrug Resistance in Acute Myeloid Leukemia (AML).
Authors: Giovanni Del Poeta, Maria Ilaria Del Principe, Adriano Venditti, Francesco Buccisano, Luca Maurillo, Carla Mazzone, Benedetta Neri, Maria Irno Consalvo, Antonio Bruno, Francesco Lo Coco, Valter Gattei, Sergio Amadori
Journal: Blood (2005)
Mortality after 10 1/2 years for hypertensive participants in the Multiple Risk Factor Intervention Trial.
Journal: Circulation (1990)

The Multiple Risk Factor Intervention Trial (MRFIT) is a randomized primary prevention trial that tested the effect of a multifactor intervention program on coronary heart disease (CHD) mortality in 12,866 high-risk men aged 35-57 years. Men were randomly assigned to either a special intervention (SI) program, which consisted of dietary advice for lowering blood cholesterol levels, counseling aimed at cessation for cigarette smokers, and stepped-care treatment for hypertension for those with elevated blood pressure, or to their usual sources of health care within the community (UC). Among the 12,866 randomized men, 8,012 (62%) were hypertensive at baseline. For this subgroup, mortality rates with 10.5 years of follow-up were lower for the SI than for the UC group by 15% (p = 0.19) for CHD and 11% (p = 0.13) for all causes. These results reflected more favorable outcomes for SI compared with UC hypertensive men during the 3.8 posttrial years (March 1982 through December 1985) than during the preceding 6-8 years (through February 1982). During the posttrial years, death rates were lower for SI than for UC men by 26% (p = 0.09) for CHD and 23% (p = 0.02) for all causes. For those with diastolic blood pressure equal to or more than 100 mm Hg, this posttrial trend was a continuation of a trend during the trial; therefore, with 10.5 years of follow-up, death rates were markedly lower for SI than for UC by 36% (p = 0.07) for CHD and 50% (p = 0.0001) for all causes. Similarly, for those without baseline resting electrocardiographic abnormalities, the favorable posttrial outcome for the SI group was a continuation of a trend during the trial. In contrast, for those with baseline diastolic blood pressure of 90-99 mm Hg and for those with baseline resting electrocardiographic abnormalities, the favorable posttrial mortality findings for the SI group were a reversal of unfavorable trends recorded during the trial. Two factors appear to have contributed to this more favorable mortality trend for the SI group: 1) a change in the diuretic treatment protocol for SI men about 5 years after randomization, which involved replacement of hydrochlorothiazide with chlorthalidone at a daily maximum dose of 50 mg; and 2) a favorable effect of intervention on nonfatal cardiovascular events during the trial years. In addition, delay until the full impact of beneficial effects on mortality end points from smoking cessation and cholesterol lowering could have contributed.(ABSTRACT TRUNCATED AT 400 WORDS)
Erk and Stat5 Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia
Authors: Shojaee Seyedmehdi, Zhengshan Chen, Maike Buchner, Christian Hurtz, Huimin Geng, Hilde Schjerven, Lai N Chan, Phillip Koeffler, Cheryl L. Willman, Stephen Hunger, Sinisa Dovat, Elisabeth Paietta, Wolf-Karsten Hofmann, Ari M Melnick, Warren S. Alexander, Steven M. Kornblau, Markus Muschen
Journal: Blood (2014)
Loss of FOXP3 Expression and Emergence of Cytokine-Producing Cells after In Vitro Expansion of Human CD4+CD25+CD127 - Regulatory T Cells.
Authors: Petra Hoffmann, Ruediger Eder, Tina J. Boeld, Jochen Huehn, Stefan Floess, Georg Wieczorek, Udo Baron, Sven Olek, Reinhard Andreesen, Matthias Edinger
Journal: Blood (2007)
The Essential Role of Stem Cell Factor/KIT Signaling in the Proliferation and Survival of Blast Cells from Transient Leukemia in Neonates with Down Syndrome.
Authors: Tsutomu Toki, Rika Kanezaki, Souichi Adachi, Hisanori Fujino, Gang Xu, Tomohiko Sato, Kahori Suzuki, Hisamichi Tauchi, Mikiya Endo, Etsuro Ito
Journal: Blood (2008)
Paternity Wishes in Young Long-Term Survivors After Allogeneic Hematopoietic Stem Cell Transplantation. A Study of the Late Effects Working Party of the EBMT
Authors: Alicia Rovo, Mahmoud Aljurf, Sandra Chiodi, Simonetta Spinelli, Nina Salooja, Gülsan Sucak, Ann E. Hunter, Tan Swee Kim, Gérard Socié, Maria Teresa van Lint, Jakob R. Passweg, Mutlu Arat, Manuela Badoglio, André Tichelli
Journal: Blood (2011)
Immune‐Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA–DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum
Authors: Simon Rothwell, Robert G. Cooper, Ingrid E. Lundberg, Peter K. Gregersen, Michael G. Hanna, Pedro M. Machado, Megan K. Herbert, Ger J. M. Pruijn, James B. Lilleker, Mark Roberts, John Bowes, Michael F. Seldin, Jiri Vencovsky, Katalin Danko, Vidya Limaye, Albert Selva‐O'Callaghan, Hazel Platt, Øyvind Molberg, Olivier Benveniste, Timothy R. D. J. Radstake, Andrea Doria, Jan De Bleecker, Boel De Paepe, Christian Gieger, Thomas Meitinger, Juliane Winkelmann, Christopher I. Amos, William E. Ollier, Leonid Padyukov, Annette T. Lee, Janine A. Lamb, Hector Chinoy
Journal: Arthritis & Rheumatology (2017)

Objective Inclusion body myositis (IBM) is characterized by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease susceptibility. To determine genetic factors contributing to the etiology of IBM, we conducted the largest genetic association study of the disease to date, investigating immune‐related genes using the Immunochip. Methods A total of 252 Caucasian patients with IBM were recruited from 11 countries through the Myositis Genetics Consortium and compared with 1,008 ethnically matched controls. Classic HLA alleles and amino acids were imputed using SNP2HLA. Results The HLA region was confirmed as the most strongly associated region in IBM ( P = 3.58 × 10 −33 ). HLA imputation identified 3 independent associations (with HLA–DRB1*03:01, DRB1*01:01, and DRB1*13:01), although the strongest association was with amino acid positions 26 and 11 of the HLA–DRB1 molecule. No association with anti–cytosolic 5′‐nucleotidase 1A–positive status was found independent of HLA–DRB1*03:01. There was no association of HLA genotypes with age at onset of IBM. Three non‐HLA regions reached suggestive significance, including the chromosome 3 p21.31 region, an established risk locus for autoimmune disease, where a frameshift mutation in CCR5 is thought to be the causal variant. Conclusion This is the largest, most comprehensive genetic association study to date in IBM. The data confirm that HLA is the most strongly associated region and identifies novel amino acid associations that may explain the risk in this locus. These amino acid associations differentiate IBM from polymyositis and dermatomyositis and may determine properties of the peptide‐binding groove, allowing it to preferentially bind autoantigenic peptides. A novel suggestive association within the chromosome 3 p21.31 region suggests a role for CCR5 .
Sick Children Crying for Help: Fostering Adverse Event Reports
Authors: Gordon D. Schiff
Journal: PLoS Medicine (2017)

In this week's PLOS Medicine, Philippa Rees and a team of patient safety experts delved into a decade of reports to the United Kingdom National Reporting and Learning System to cull more than 2,000 events occurring in sick children [1].Their retrospective finding of key areas of outpatient harm and risk points to a number of specific areas for improvement.The study is valuable both for the specific findings, lessons, and insights and also for encouraging us to grapple with the value of such reporting systems, analysis of collected reports, and ways of better leveraging findings to prevent harm in the future.Representative of the state of the art in incident reporting and review, there is cause for celebration as well as concern-celebration because assembling a large number of case reports allows us to step back and get beyond these single/isolated/disconnected reports to see a bigger picture, and concern because one has to worry that two decades of such efforts to collect, classify, draw conclusions, and effectively stimulate corrective changes from adverse events has resulted in a paucity of measurable benefits, with considerable wasted effort and lost opportunities for meaningful learning and improvement [2][3][4].While not a pediatrician, as a primary care physician and patient safety researcher I have spent considerable time both submitting and reviewing safety reports [5,6].At one point, I had filed more error and adverse drug reactions reports than all the other physicians at my public hospital in Chicago combined, making me either the institution's most dangerous prescriber or its most diligent reporter [7].Hoping it is more the latter, it is sobering to consider how infrequently adverse events and errors are being reported.Not only are we missing many adverse events, but those being reported likely are not perfectly representative of all errors that are occurring [8].Thus, it is neither advisable nor fair to use report rates (or changes in rates) as measures of the epidemiology of quality or improvement efforts.Thus, I would caution readers to be wary of accepting the authors' opening suggestion that we can correlate these reported safety issues with poorer outcome measures or higher mortality rates of the United Kingdom relative to other European countries.But what about the reports themselves-this wealth of rich case examples of actual problems transmitted straight from the front lines?We certainly have a debt to those who took the time and effort and perhaps even took risks to report these adverse events and owe them (as well as patients who may have been harmed) meaningful follow-up, learning, feedback, sharing, and improvement.In-depth examination both horizontally (to connect the reports with each other to see aggregate data and trends) and vertically (to dig deeper, delving into the rich details of the free-text narrative details that accompany a good report) as the authors have done is needed, yet is more often the exception than the rule.While I am not aware of any
Venereal Transmission of Enteric Pathogens in Male Homosexuals
Authors: Donna Mildvan
Journal: JAMA (1977)

In two cases there was simultaneous or sequential occurrence of amebiasis, shigellosis, and giardiasis in male homosexuals. Enteric pathogens may, under the proper conditions, be venereally transmitted. In particular, the sexual practices of male homosexuals, most significantly, oral-anal contact, appear to provide the necessary link for transmission. Evidence suggests that this is a growing problem. (<i>JAMA</i>238:1387-1389, 1977)
Laparoscopic versus open surgery for rectal cancer: A meta-analysis of classic randomized controlled trials and high-quality Nonrandomized Studies in the last 5 years
Authors: Ke Chen, Guodong Cao, Bo Chen, Mingqing Wang, Xingyu Xu, Wenwen Cai, Yicheng Xu, Maoming Xiong
Journal: International Journal of Surgery (2017)
Renal tubular resistance is the primary driver for loop diuretic resistance in acute heart failure
Authors: Jozine M. ter Maaten, Veena S. Rao, Jennifer S. Hanberg, F. Perry Wilson, Lavanya Bellumkonda, Mahlet Assefa, J. Sam Broughton, Julie D'Ambrosi, W.H. Wilson Tang, Kevin Damman, Adriaan A. Voors, David H. Ellison, Jeffrey M. Testani
Journal: European Journal of Heart Failure (2017)
A Prognostic Score for Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma: Analysis of 2189 Patients.
Authors: Apostolia-Maria Tsimberidou, Peter McLaughlin, Susan O’Brien, Sijin Wen, William G. Wierda, John Manning, Susan Lerner, Mark A. Hess, Hagop Kantarjian, Emil J. Freireich, Michael J. Keating
Journal: Blood (2006)
Identification of Neoplastic Infiltration of the Cerebrospinal Fluid (CSF) in Patients with Aggressive B-Cell Non-Hodgkin’s Lymphoma (B-NHL) without Clinical Evidence of Leptomeningeal Disease: A Comparative Analysis of the Utility of Flow Cytometry (FCM) Versus Conventional Cytology (CC).
Authors: A. Orfao, S. Quijano, A. Lopez, G. Deben, A. Salar, C. Poderos, J.M. Sancho, C. Vallejo, J. Arias, J.A. Garcia, F. Capote, M. Morado, C. Nicolas, J. Briones, S. Fernandez, A. Carmona, L. Vazquez, J.F. San Miguel
Journal: Blood (2006)
STXBP4 Drives Tumor Growth and Is Associated with Poor Prognosis through PDGF Receptor Signaling in Lung Squamous Cell Carcinoma
Authors: Yukihiro Otaka, Susumu Rokudai, Kyoichi Kaira, Michiru Fujieda, Ikuko Horikoshi, Reika Iwakawa-Kawabata, Shinji Yoshiyama, Takehiko Yokobori, Yoichi Ohtaki, Kimihiro Shimizu, Tetsunari Oyama, Jun'ichi Tamura, Carol Prives, Masahiko Nishiyama
Journal: Clinical Cancer Research (2017)

Purpose: Expression of the ΔN isoform of p63 (ΔNp63) is a diagnostic marker highly specific for lung squamous cell carcinoma (SCC). We previously found that Syntaxin Binding Protein 4 (STXBP4) regulates ΔNp63 ubiquitination, suggesting that STXBP4 may also be an SCC biomarker. To address this issue, we investigated the role of STXBP4 expression in SCC biology and the impact of STXBP4 expression on SCC prognosis.Experimental Design: We carried out a clinicopathologic analysis of STXBP4 expression in 87 lung SCC patients. Whole transcriptome analysis using RNA-seq was performed in STXBP4-positive and STXBP4-negative tumors of lung SCC. Soft-agar assay and xenograft assay were performed using overexpressing or knockdown SCC cells.Results: Significantly higher levels of STXBP4 expression were correlated with accumulations of ΔNp63 in clinical lung SCC specimens (Spearman rank correlation ρ = 0.219). Notably, STXBP4-positive tumors correlated with three important clinical parameters: T factor (P < 0.001), disease stage (P = 0.030), and pleural involvement (P = 0.028). Whole transcriptome sequencing followed by pathway analysis indicated that STXBP4 is involved in functional gene networks that regulate cell growth, proliferation, cell death, and survival in cancer. Platelet-derived growth factor receptor alpha (PDGFRα) was a key downstream mediator of STXBP4 function. In line with this, shRNA mediated STXBP4 and PDGFRA knockdown suppressed tumor growth in soft-agar and xenograft assays.Conclusions: STXBP4 plays a crucial role in driving SCC growth and is an independent prognostic factor for predicting worse outcome in lung SCC. These data suggest that STXBP4 is a relevant therapeutic target for patients with lung SCC. Clin Cancer Res; 23(13); 3442-52. ©2017 AACR.
The Ethnopharmacologic Contribution to Bioprospecting Natural Products
Authors: Eric J. Buenz, Rob Verpoorte, Brent A. Bauer
Journal: The Annual Review of Pharmacology and Toxicology (2017)

Descriptions of the use of natural products in traditional medicine have served as starting points for new therapeutics. The details of the traditional use of these organisms can provide important information for future drug discovery and development efforts. Recent technologic advances provide the framework to leverage ethnopharmacologic data in the drug discovery process. Information on the traditional harvest, preparation, storage, and administration of the organisms, and the natural products they contain, provides valuable details regarding characteristics of the active compounds. Importantly, researchers can now rapidly analyze and identify the multiple, and often synergistic, compounds contained in these natural products. Although we are entering the acme of ethnopharmacology, where information regarding the traditional use of organisms can provide valuable natural product leads and accelerate the identification of new therapeutics, this ethnopharmacologic resource is threatened by the loss of traditional medicine knowledge and extinction of organisms.
Scattome: A Single-Cell Analysis of Targeted Transcriptome Program to Predict Drug Sensitivity of Single Cells within Human Myeloma Tumors
Authors: Amit Kumar Mitra, Ujjal Mukherjee, Taylor Harding, Holly Stessman, Ying Li, Jen Jin, Shaji K Kumar, S. Vincent Rajkumar, Brian G Van Ness
Journal: Blood (2015)
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
Authors: Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang, Yunpeng Liu
Journal: Molecular Cancer (2017)

The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical studies, targeting of the insulin-like growth factor-I receptor (IGF-IR) showed promising anti-tumor effects. Unfortunately, high expectations for anti-IGF-IR therapy encountered challenge and disappointment in numerous clinical trials. This review summarizes the regulation of EMT by IGF-I/IGF-IR signaling pathway and drug resistance mechanisms of targeting IGF-IR therapy. Most importantly, we address several factors in the regulation of IGF-I/IGF-IR-associated EMT progression that may be potential predictive biomarkers in targeted therapy.
Interim Analysis of a Multicenter Trial of High Dose (HD) Imatinib in Newly Diagnosed Early Chronic Phase (CP) Patients (pt) with Chronic Myeloid Leukemia (CML).
Authors: Jorge Cortes, Francis Giles, August J. Salvado, Karen McDougall, Jerald Radich, Mahir Albitar, Bayard L. Powell, Stuart Goldberg, Hagop M. Kantarjian
Journal: Blood (2005)
Review: Metabolic Regulation of Inflammation in Osteoarthritis
Authors: Francis Berenbaum, Timothy M. Griffin, Ru Liu‐Bryan
Journal: Arthritis & Rheumatology (2016)

Osteoarthritis (OA) has long been considered the unique consequence of a tear and wear
process leading to cartilage degradation. Indeed, it is true that an excessive mechanical stress on any joint leads to cartilage loss, with the production of osteophytes being considered a reactive process of the bone to protect and stabilize the altered joint (1). This initial paradigm has been slowly but deeply modified in the past 20 years due to critical discoveries (2).