tbuckley/cabot-search huggingface dataset:
Abstract 5116: Detection of pancreatic cancer using acidic pH targeted probes detected using multispectral optoacoustic tomography
Authors: Matthew Zeiderman, Anil Khanal, Charles W. Kimbrough, Jorge Gomez, William E. Grizzle, Kelly M. McMasters, Lacey R. McNally
Journal: Cancer Research (2015)

Abstract Introduction: The use of theranostic nanoparticles for simultaneous tumor imaging and drug delivery is of great research interest. The tumor extracellular environment is significantly more acidic than physiologic pH, often in the range of pH 6.0-6.8. Exploitation the acidic extracellular tumor environment is a promising method of tumor localization with pH sensitive probes and targets. Further, the use of multispectral optoacoustic tomography (MSOT) allows in vivo 3D tumor imaging via gold nanoparticles or near-infrared dyes conjugated to a targeting molecule. Gemzar is used for first-line treatment of pancreatic adenocarcinoma, a malignancy with less than 5% survival at 5 years. We have created chitosan-capped mesoporous silica gold nanorods (C-MS-GNRs) to serve as pH sensitive theranostic nanoparticles for in vivo tumor imaging and targeted drug delivery. Methods: The chemical nature of all particles were characterized by electron microscopy, UV-Vis, and zeta-potential. Acidic pH specific Gemzar release was measured from C-MS-GNRs by UV-Vis. Cell viability assays on S2VP10 pancreatic adenocarcinoma cells with G-C-MS-GNR and Gemzar alone were performed at pH 6.5 and 7.4. S2VP10 cells were treated in pH 6.5 or 7.4 media with C-MS-GNR loaded with Indocyanin green (ICG) to demonstrate pH-sensitive cell targeting. ICG uptake was read on an Odyssey imaging system. Results: Particle characterization demonstrated appropriate chemical composition. A drug release assay of G-C-MS-GNR demonstrated 1/10 as much drug release at pH7.4 compared to in pH 6.4 or 6.0 media. Cell viability assays demonstrated enhanced cytotoxicity with Gemzar loaded C-MS-GNR at pH 6.5 and 7.4 compared to Gemzar alone. In vitro treatment of S2VP10 cells with C-MS-ICG in pH 6.5 media demonstrated 8X greater ICG delivery by C-MS-ICG than observed at pH 7.4. Conclusions: C-MS-GNR provides an efficacious means of targeting the acidic tumor environment for in vivo tumor imaging and drug delivery. C-MS-GNRs may be a suitable vehicle for tumor-targeted, pH-sensitive drug delivery to this currently untreatable tumor. Citation Format: Matthew Zeiderman, Anil Khanal, Charles W. Kimbrough, Jorge Gomez, William E. Grizzle, Kelly M. McMasters, Lacey R. McNally. Detection of pancreatic cancer using acidic pH targeted probes detected using multispectral optoacoustic tomography. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 5116. doi:10.1158/1538-7445.AM2015-5116
Adjuvant chemotherapy in osteogenic sarcoma: the triumph that isn't?
Authors: S K Carter
Journal: Journal of Clinical Oncology (1984)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1984.2.3.147 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 6583329 Adjuvant chemotherapy in osteogenic sarcoma: the triumph that isn't? S K CarterxS K CarterSearch for articles by this author https://doi.org/10.1200/JCO.1984.2.3.147 PDF "Adjuvant chemotherapy in osteogenic sarcoma: the triumph that isn't?." Journal of Clinical Oncology, 2(3), pp. 147–148© 1984 by American Society of Clinical Oncology
Intracranial Recurrence of Carcinoma after Complete Surgical Resection of Stage I, II, and III Non-Small-Cell Lung Cancer
Authors: R A Figlin, S Piantadosi, R Feld
Journal: New England Journal of Medicine (1988)

We retrospectively analyzed the risk of intracranial recurrence of cancer in 1532 patients who were surgically treated between 1977 and 1986 for Stage I, II, or III non-small-cell lung cancer, after rigorous surgical and pathological staging. This analysis was undertaken as a background for a possible randomized clinical trial of prophylactic cranial irradiation in such patients. One hundred four patients (6.8 percent) had documented first recurrences involving the brain, including 98 patients (6.4 percent) in whom the brain was the sole site of first recurrence. Sixty patients (3.9 percent) had only intracranial involvement at the time of death. Prognostic variables that had a significant effect on the time to recurrence in the brain were histologic features of the carcinoma (patients with nonsquamous-cell cancers were more at risk than those with squamous-cell cancer), the T1N1/T2N0 and T2N1 staging subsets (T1, tumor ±3 cm in diameter; T2, tumor >3 cm; N0, no regional lymph-node metastasis; N1, ipsilateral hilar-lymph-node metastasis), and initial weight loss of more than 10 percent. We conclude that prophylactic cranial irradiation would at best benefit only a very small subset of these patients. We believe, therefore, that neither prophylactic cranial irradiation nor a randomized trial is indicated in patients with non-small-cell lung cancer who have undergone complete resection. (N Engl J Med 1988; 318:1300–5.)
Abstract B24: Targeting promoter regions of oncogenic drivers in pediatric AML cells using G-quadruplex Interacting Drugs (GQIDs)
Authors: Apurvi Patel, Justin J. Montoya, Megan Turnidge, Marya Sabir, Daniel H. Wai, David W. Lee, Vijay Gokhale, Eiman Aleem, Laurence J. Hurley, Robert J. Arceci, David O. Azorsa
Journal: Cancer Research (2016)

Abstract Cancer is primarily a disease characterized by aberrant gene expression that is manifested by the overexpression of key genes that support tumor development and maintenance. In many instances, oncogenic drivers are frequently ‘undruggable’ because of structural challenges, the inability to effectively inhibit high concentrations of overexpressed proteins, and the development of drug resistance mutations. An alternative therapeutic approach is to directly inhibit gene transcription by targeting unique secondary DNA structures, called G-quadruplexes, that are associated with subsets of promoters. Our laboratory investigated the activity of a class of compounds termed G-quadruplex Interacting Drugs (GQIDs) that are able to shut down the expression of specific genes used by tumor cells for growth and survival. We tested the activity of two GQIDs GQC-05 and GSA-1103 on cell growth of a panel of eight pediatric and eight adult AML cell lines. Drug dose response analysis showed IC50 values ranging from approximately 10 nM to 1 µM for GQC-05 and from 40 nM to 2 µM for GSA-1103. The AML cell lines had different sensitivities to each GQID indicating a different mechanism of action for each compound. Three AML cell lines that were highly resistant to cytarabine were among the more sensitive to GQC-05. Four cell lines sensitive to GQC-05 had high expression of either c-myc and/or bcl-2, both of which are potential targets of these two GQIDs. Furthermore, treatment of cells with the GQC-05 decreased expression of c-myc and bcl-2. These studies will help define a novel approach of repressing key drivers of leukemia by targeting selective promoter structures. Validation of such an approach for AML will have important implications for testing this therapeutic approach to other childhood cancers in order to improve the length and quality of survival. Citation Format: Apurvi Patel, Justin J. Montoya, Megan Turnidge, Marya Sabir, Daniel H. Wai, David W. Lee, Vijay Gokhale, Eiman Aleem, Laurence J. Hurley, Robert J. Arceci, David O. Azorsa. Targeting promoter regions of oncogenic drivers in pediatric AML cells using G-quadruplex Interacting Drugs (GQIDs). [abstract]. In: Proceedings of the AACR Special Conference on Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship; 2015 Nov 9-12; Fort Lauderdale, FL. Philadelphia (PA): AACR; Cancer Res 2016;76(5 Suppl):Abstract nr B24.
P0810 : Sofosbuvir and daclatasvir combined treatment for chronic hepatitis C: First-year efficacy and safety data in a real-life setting
Authors: A.-J. Rémy, A. Pariente, J.-P. Arpurt, I. Rosa-Hézode, C. Renou, R. Arotcarena, G. Macaigne, H. Lison, F. Bourhis, X. Causse, A. Pauwels, S. de Montigny-Lenhardt, V. Jouannaud, H. Labadie, E. Maringe, J.-H. Salloum, E. Gagea, H. Hagège, B. Lesgourgues
Journal: Journal of Hepatology (2015)
Serial Courses of Corticotrophin or Cortisone in Chronic Bronchial Asthma
Authors: Robert P. McCombs
Journal: New England Journal of Medicine (1952)

THE efficacy of corticotrophin (ACTH) and cortisone in relieving the acute paroxysms of bronchial asthma has been observed by many, and it has been recognized that periods of complete freedom lasting several weeks or months may be induced by a single course of hormone therapy.1 2 3 4 5 It has not as yet been established, however, what place hormone therapy will have in the long-term management of chronic or recurrent asthma. The present communication is concerned with an analysis of the clinical course in 5 asthmatic patients who have received from 13 to 23 different courses of treatment with corticotrophin or cortisone over . . .
Transmission of Hepatitis C Virus -- Route, Dose, and Titer
Authors: Miriam J. Alter
Journal: New England Journal of Medicine (1994)

Hepatitis C virus (HCV) is a blood-borne virus that generally circulates in low titers in infected serum. Epidemiologic studies show that the most efficient transmission of HCV is through the transfusion of blood or blood products or the transplantation of organs from infected donors and through the sharing of contaminated needles among injection-drug users1. However, less than half of patients with acute hepatitis C report a history of such exposure. A small number of epidemiologic studies demonstrate that perinatal, sexual, household, and occupational transmission occurs, but our understanding of the risks of transmission in these settings has been limited . . .
Safety analysis of a novel induction chemotherapy (IC) regimen of weekly nanoparticle albumin-bound (<i>nab</i>-)paclitaxel and cetuximab with every 3 week cisplatin and 5-FU in 30 patients (pts) with locally advanced nonmetastatic head and neck squamous cell carcinoma (HNSCC).
Authors: D. I. Kuperman, J. Ley, B. Nussenbaum, J. Diaz, R. Paniello, W. L. Thorstad, H. A. Gay, J. Subramanian, T. M. Wildes, J. Mathai, T. Rachocki, D. Adkins
Journal: Journal of Clinical Oncology (2011)

e16025 Background: Favorable response at the primary tumor site to IC (with cisplatin and 5-FU) correlates with disease control after subsequent definitive radiation-based therapy (RT) in pts with HNSCC. SPARC, an albumin binding protein that is commonly over-expressed in HNSCC, may facilitate preferential accumulation of nab-paclitaxel at tumor sites compared to other formulations of paclitaxel. Methods: An objective of this prospective phase II trial was to determine the safety of an IC regimen of weekly nab-paclitaxel (100 mg/m2) and cetuximab (250 mg/m2) with every 3 week cisplatin (75 mg/m2) and 5-FU (750 mg/m2 per day x3 CIVI; ACCF) given for three cycles in pts with locally advanced HNSCC. Pts then received definitive chemo-RT. The assessment of adverse events (AE) occurred weekly during ACCF and was graded using NCI-CTC V3 criteria. The incidence of grade (G) 3/4/5 AEs in pts with this IC regimen was expected to be 15% and the maximum allowable incidence was 35%. An interim safety analysis was performed after 10 pts were enrolled and no major safety signals were observed. Twenty additional pts completed treatment. Results: Of the 30 pts, 7 (23%) experienced G 3/4 AEs and 1 (3%) experienced a G5 AE that were viewed as at least possibly related to ACCF. The key AEs that occurred in each of these 8 pts included: infusion reaction to cetuximab (1), neutropenia/pneumonia (1), calf DVT (1), mucositis (1), rectal abscess (1), and asymptomatic neutropenia (3). Eight other pts experienced G 3/4 AEs attributed to other causes (pre-existing co-morbidities or present at baseline): cardiac (1 pt), stroke (1 pt), port-related DVT (3 pts), low Na+ (1 pt), lymphopenia (1 pt) and fatigue (1 pt). Acneiform rash due to cetuximab occurred in 24 pts overall (G3 in 4 pts). Other selected AEs included G1 peripheral neuropathy in 6 pts and renal dysfunction in 7 pts (G1&2- 6 pts; G3-1 pt), the latter resulting in a protocol amendment to add IV fluids for days 2 and 3 after cisplatin. Conclusions: The safety review of the 30 pts treated with ACCF demonstrated an acceptable toxicity profile.
Intestinal Ulceration – A Complication of Celiac Disease
Authors: Theodore M. Bayless, Robert F. Kapelowitz, William M. Shelley, Walter F. Ballinger, Thomas R. Hendrix
Journal: New England Journal of Medicine (1967)

IN the past, the complications attributable to celiac disease (nontropical sprue) have almost entirely been secondary to malabsorption of nutrient materials, and death directly due to this disease has been rare. Since the consequences of malabsorption in celiac disease, as well as the histologic lesion of the jejunal mucosa, are correctable by exclusion of dietary gluten, the prognosis in treated celiac disease is excellent.The purpose of this report is twofold: to describe a sequence of complications including intestinal ulcerations, perforation and stricture leading to death in a patient with well documented celiac disease during treatment with a gluten-free diet; . . .
Case 36-1966
Authors: Samuel L. Katz, Benjamin Castleman
Journal: New England Journal of Medicine (1966)

Presentation of Case*A six-month-old boy was admitted to the hospital because of fever and dyspnea.The child was the product of a normal pregnancy and delivery and weighed 7 pounds, 14 ounces, at birth. He ate well, and his growth and development were normal. One month before admission he was dropped by a sibling. X-ray films of the skull disclosed a linear fracture of the right parietal bone, extending vertically from the vertex to the squamosal suture. Admission to the hospital was refused by the parents, and he appeared well during the following week. Three weeks before entry he . . .
Endpiece: Shallow animals
Authors: Peter Morrell
Journal: BMJ (2005)

A Physician who should even be a Theist, still more a Christian, would be a rarity indeed. I do not know one. And I know a great many Physicians. They are shallow Animals: having always employed their minds about Body and Gut, they imagine that in the whole system of things there is nothing but Gut and Body.

Collected letters of Samuel Taylor Coleridge, edited by Earl Leslie Griggs, quoted in Vickers N. Coleridge and the doctors. Oxford: Oxford University Press, 2004:18
Case 50-1974
Authors: Richard C. Cabot, Robert E. Scully, Betty U. McNeely, Thomas F. Necheles, Stanley J. Robboy
Journal: New England Journal of Medicine (1974)

Presentation of CaseA 12-month-old girl was admitted to the hospital because of a thoracoabdominal mass.She was born of a normal pregnancy, labor and delivery and was well until three months before admission, when she began to have diarrhea after each feeding. Elimination of cow's milk and other potential allergens had no effect, and she became increasingly fussy.Three weeks before entry abdominal distention was observed, and the child vomited several times. One week later she was admitted to another hospital. A film of the chest and abdomen (Fig. 1) disclosed a large fusiform mass that appeared to extend . . .
Case 22-2003
Authors: Johanna P. Daily, Mary Ann Waldron
Journal: New England Journal of Medicine (2003)

Presentation of CaseA 22-year-old man was examined in the clinic because of fever, chills, and thrombocytopenia.Five months earlier, the patient, who was late in planning a six-week trip to South America, had received vaccines against hepatitis B and yellow fever and had begun taking doxycycline daily for prophylaxis against malaria. One week later, he and a group of others traveled to northern Ecuador, had a prolonged stay in the jungle, and swam in the “dark water” of lakes and rivers. At night, they used mosquito netting and applied a 30 percent N,N-diethyl-3-methylbenzamide (DEET) spray, but the patient . . .
Epidemic Salmonellosis in Hospitals and Institutions
Authors: Steven A. Schroeder, Bernard Aserkoff, Philip S. Brachman
Journal: New England Journal of Medicine (1968)

During the period 1963–1967 the Salmonella Surveillance Report recorded 40 epidemics of salmonellosis in hospitals and institutions, involving 3025 patients and 43 deaths. Epidemics occurred in newborn nurseries, pediatric wards, general-hospital wards, nursing homes and mental institutions. Epidemics involving children were smaller and associated with higher case fatality ratios and more often spread by cross-infection than outbreaks affecting adults. Common-vehicle outbreaks were usually limited to adults and were most frequently due to eggs or egg products. Early detection of outbreaks requires an alert hospital surveillance system. In common-vehicle outbreaks, the contaminated vehicle must be identified and removed. In cross-infection outbreaks, a search for human excreters and contaminated environmental objects must be made. Cross-infection outbreaks are difficult to halt and require vigorous enforcement of hygienic technics, isolation of salmonella excreters and patients admitted with diarrhea (pending stool-culture results) and early discharge of infected patients.
Grief Response of Parents after Referral of the Critically Ill Newborn to a Regional Center
Authors: D. Gary Benfield, Susan A. Leib, Jeanette Reuter
Journal: New England Journal of Medicine (1976)

Attitudes, feelings, and behavior were studied in 101 mother-father pairs whose critically ill newborn infants survived after referral from the hospital of birth to a regional neonatal intensive-care unit for special care. As measured by an anticipatory-grief score, most parents experienced grief reactions similar to those whose infants do not survive the newborn period. The level of anticipatory grief did not appear to be associated with severity of infant illness as determined by the need for respirator therapy or major surgical procedures. The fathers reported drastic alteration in daily activity while wife and infant were hospitalized in separate facilities, and they assumed a central role in maintaining family stability during the crisis. These data suggest that an organized family-support program could play a prominent part in maintaining family stability during the delivery of newborn intensive care.
Augmentation by Erythropoietin of the Fetal-Hemoglobin Response to Hydroxyurea in Sickle Cell Disease
Authors: Griffin P. Rodgers, George J. Dover, Nobuhiro Uyesaka, Constance T. Noguchi, Alan N. Schechter, Arthur W. Nienhuis
Journal: New England Journal of Medicine (1993)

Hydroxyurea increases the production of fetal hemoglobin in patients with sickle cell anemia, inhibiting the polymerization of hemoglobin S and potentially improving vaso-occlusive manifestations and hemolysis. Recombinant erythropoietin increases the number of reticulocytes containing fetal hemoglobin in laboratory animals and in humans. We studied whether hydroxyurea and erythropoietin might have a potentiating effect on the production of fetal hemoglobin in patients with sickle cell disease.
A Proposal to Restructure Hospital Care for Dying Patients
Authors: Franklin G. Miller, Joseph J. Fins
Journal: New England Journal of Medicine (1996)

Data from the recent Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatment (SUPPORT) indicate that the care of hospitalized dying patients continues to be inadequate.1 We propose a restructuring of hospital care for dying patients through the introduction of a hospice-like alternative-care unit designed to provide palliative care to dying patients who have been transferred from the intensive care unit (ICU). By functionally integrating these two modes of care, the hospital would legitimize palliative care strategies for critically ill patients, help patients and their families clarify goals, and facilitate a process of shared decision making concerning . . .
Relation of Superior-Mesenteric-Artery Obstruction to Renal Hypertension
Authors: David T. Schwartz
Journal: New England Journal of Medicine (1965)

BLALOCK et al.1 demonstrated in dogs that unilateral renal-artery constriction resulted in a greater rise in blood pressure if the superior mesenteric artery was also previously constricted. Furthermore, in their animals the hypertension was sustained for at least one year, whereas Goldblatt and his associates2 had found that hypertension produced by constriction of only one renal artery was sustained for less than six weeks unless contralateral nephrectomy was performed. Constriction of the superior mesenteric artery alone had no effect on blood pressure.3 These experiments showed that superior-mesenteric-artery insufficiency enhanced the hypertension of renal-artery insufficiency by an unknown mechanism.Pertinent case . . .
Case 6-2009
Authors: Didier Cros, R. Gilberto Gonzalez, Eugene J. Mark
Journal: New England Journal of Medicine (2009)

A 37-year-old woman had a 4-month history of episodes of vertigo, followed by tinnitus, decreased hearing in her right ear, and right facial weakness; on the day of admission, she had a generalized seizure. On admission, she was confused and combative and had garbled speech, a right facial droop, and generalized hyperreflexia. Magnetic resonance imaging of the brain and spinal cord revealed multifocal linear and nodular enhancement of the leptomeninges. A diagnostic procedure was performed.
Reactions to Benzathine Penicillin
Authors: Robert B. McFarland
Journal: New England Journal of Medicine (1958)

REACTIONS to penicillin constitute a continuing hazard with which all physicians must contend. Benzathine penicillin G, a recent development in penicillin therapy, is effective in infections caused by organisms susceptible to low but prolonged blood levels of penicillin. A single injection of 600,000 units is widely used by the armed forces to terminate and prevent streptococcal epidemics. As with all penicillin preparations, the resulting allergic reactions are the main disadvantage of its use. This paper describes the reactions to this agent in 175 patients resulting from a total of 12,858 single injections to separate persons.MethodsThe reasons for and . . .
Hypertrophic Cardiomyopathy — Beyond the Sarcomere
Authors: Martin St. John Sutton, Jonathan A. Epstein
Journal: New England Journal of Medicine (1998)

Remodeling of the left ventricle by the process of hypertrophy is usually a response to increased afterload. This adaptive reaction maintains cardiac output. The most common pattern of hypertrophy is concentric remodeling due to systemic hypertension, in which there is replication of sarcomeres in parallel. Hypertrophy also results from genetic mutations involving the contractile apparatus, as in hypertrophic cardiomyopathy, which is unrelated to changes in afterload.Echocardiography has made it possible to quantify hypertrophy and to describe the effects of hypertrophic cardiomyopathy on left ventricular architecture and function. These patterns have proved invaluable in identifying phenotypic expression in family pedigrees. . . .
Bilateral Atrial Myxomas Associated with Hyperpigmented Skin Lesions
Authors: Offer Amir, Amnon Merdler, Avinoam Shiran
Journal: New England Journal of Medicine (2001)

To the Editor: A 51-year-old white man was admitted to the hospital because of fever, weight loss, and several episodes of systemic embolization, manifested as sharp, left-sided flank pain with macrohematuria and episodes of painful purple discoloration of his fingers and toes. Seven years earlier, a pigmented nevus (0.7 by 0.4 cm) had been excised from his upper back and diagnosed as malignant melanoma, with invasion of the skin to the level of the papillary dermis (Clark level III). On examination, the patient had skin phototype 2 (i.e., skin that usually burns and sometimes tans), with various hyperpigmented cutaneous lesions, . . .