tbuckley/cabot-search huggingface dataset:
INFLUENCE OF RUN AND CUT MANOEUVRES ON PATELLOFEMORAL KINETICS AND KINEMATICS
Authors: J Sinclair, S Dillon
Journal: British Journal of Sports Medicine (2016)

Patellofemoral pain syndrome is the most common knee pathology. Those with patellofemoral pain are much more likely to be physically active than age-matched controls. The prevalence of patellofemoral pain in athletic populations is considered to be between 8–40 %. It has been suggested that patellofemoral pain may serve as a precursor to the progression of osteoarthritic symptoms in later life. The effects of different sports tasks on patellofemoral kinetics and kinematics has received a paucity of research attention. The aim of the current investigation was to explore differences in patellofemoral kinetics and kinematics during the run and cut manoeuvres. Ten male participants took part in this investigation. They performed run and 45˚ cut movements using an approach velocity of 4.0 m.s −1 . Three-dimensional kinematics of the thigh, shank and patella segments were quantified using retro reflective markers via an eight camera motion capture system which operated at 250 Hz. In addition to this patellofemoral kinetics were quantified using a musculoskeletal modelling approach. Differences between manoeuvres were explored statistically using paired samples t-tests. The results showed that patellofemoral force (Cut=4.65 &amp; Run=4.11 Bodyweights) and pressure (Cut=12.32 &amp; Run=10.93 MPa) were larger in the cut movement compared to the run. In addition patella angular range of motion was larger in the sagittal (Cut=11.66 &amp; Run=7.89°) and transverse (Cut=13.55 &amp; Run=7.57°) planes when performing the cut movement in comparison to the run. In conclusion given the association between patellofemoral loading/ patella mal-alignment and the aetiology of patellofemoral pain syndrome, the current study indicates that the cut manoeuvre may place athletes at increased risk from injury.
Treatment with mTOR Inhibitor, Everolimus (RAD001) Overcomes Resistance to Imatinib in Ph-Leukemia Quiescent or T315I-Mutated Cells.
Authors: Yosuke Minami, Miho Minami, Yachiyo Kuwatsuka, Ryohei Tanizaki, Yuka Nomura, Akihiro Abe, Hitoshi Kiyoi, Tomoki Naoe
Journal: Blood (2009)
Taxanes Induce a Rapid Mobilization of Different Populations of Circulating Endothelial Progenitors by SDF-1 Modulation in Cancer Patients.
Authors: Anna Bono, Jessica Quarna, Paola Marighetti, Angelica Calleri, Pierluigi Antoniotti, Patrizia Mancuso, Emile E Voest, Marlies Langenberg, Jeanine Roodhart, Yuval Shaked, Robert S Kerbel, Francesco Bertolini
Journal: Blood (2008)
Pyrrolo[2,3-b]Pyridinic Derivatives Induce Cell Growth Inhibition of the Myeloblastic HL-60 Cell Line.
Authors: Maylis Decrop, Claire Espanel, Jerome Guillard, Elodie Boissier, Nathalie Gallay, Christian Binet, Marie-Claude Viaud-Massuard, Olivier Herault
Journal: Blood (2006)
Increase of CD4+CD25high Regulatory T Cells in the Peripheral Blood of Acute Myeloid Leukemia Patients.
Authors: Xingbing Wang, Junxia Yao, Jine Zheng, Jun Liu, Yanli He, Xiaoqing Li, Jingming Yu, Jun Wei, Jin Yang, Zhongping Liu, Shiang Huang
Journal: Blood (2004)
Unusual Sites of Involvement in Non-Hodgkin’s Lymphoma
Authors: Charmaine Hon, Wing Y. Au, Edmond S.K. Ma, Alvin K.H. Kwok, Albert K.W. Lie, Raymond H.S. Liang
Journal: Journal of Clinical Oncology (2002)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2002.20.21.4394 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 12409339 Unusual Sites of Involvement in Non-Hodgkin’s Lymphoma Case 1. Isolated Orbit Relapse After Allogeneic Bone Marrow Transplantation for Malignant Lymphoma Charmaine HonxCharmaine HonSearch for articles by this author , Wing Y. AuxWing Y. AuSearch for articles by this author , Edmond S.K. MaxEdmond S.K. MaSearch for articles by this author , Alvin K.H. KwokxAlvin K.H. KwokSearch for articles by this author , Albert K.W. LiexAlbert K.W. LieSearch for articles by this author , Raymond H.S. LiangxRaymond H.S. LiangSearch for articles by this author Show More Queen Mary Hospital; University of Hong Kong; and Hong Kong Eye Hospital, Chinese University of Hong Kong, Hong Kong https://doi.org/10.1200/JCO.2002.20.21.4394 First Page Full Text PDF Figures and Tables © 2002 by American Society of Clinical Oncology
HTLV-1 Enhances Epstein-Barr Virus (EBV) Infectivity and EBV Infection Attributes to an Aggressive Organ Involvement in Adult T-Cell Leukemia.
Authors: Satomi Ueda, Yasuhiro Maeda, Terufumi Yamaguchi, Yasuki Hijikata, Akihisa Kanamaru
Journal: Blood (2004)
Combination of CD34/CD38 Immunophenotypes and Side Population (SP) Reveals the Putative Leukemia Stem Cell/Leukemia Initiating Cell In Acute Myeloid Leukemia.
Authors: Gerrit J Schuurhuis, Bijan Moshaver, Alexander N Snel, Gert J. Ossenkoppele, Sonja Zweegman
Journal: Blood (2010)
Multi-Institutional Prospective Study of Reirradiation with Proton Beam Radiotherapy for Locoregionally Recurrent Non–Small Cell Lung Cancer
Authors: Hann-Hsiang Chao, Abigail T. Berman, Charles B. Simone, Christine Ciunci, Peter Gabriel, Haibo Lin, Stefan Both, Corey Langer, Kristi Lelionis, Ramesh Rengan, Stephen M. Hahn, Kiran Prabhu, Marcio Fagundes, William Hartsell, Rosemarie Mick, John P. Plastaras
Journal: Journal of Thoracic Oncology (2016)
Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update
Authors: Betty R. Ferrell, Jennifer S. Temel, Sarah Temin, Erin R. Alesi, Tracy A. Balboni, Ethan M. Basch, Janice I. Firn, Judith A. Paice, Jeffrey M. Peppercorn, Tanyanika Phillips, Ellen L. Stovall, Camilla Zimmermann, Thomas J. Smith
Journal: Journal of Clinical Oncology (2017)

Purpose To provide evidence-based recommendations to oncology clinicians, patients, family and friend caregivers, and palliative care specialists to update the 2012 American Society of Clinical Oncology (ASCO) provisional clinical opinion (PCO) on the integration of palliative care into standard oncology care for all patients diagnosed with cancer. Methods ASCO convened an Expert Panel of members of the ASCO Ad Hoc Palliative Care Expert Panel to develop an update. The 2012 PCO was based on a review of a randomized controlled trial (RCT) by the National Cancer Institute Physicians Data Query and additional trials. The panel conducted an updated systematic review seeking randomized clinical trials, systematic reviews, and meta-analyses, as well as secondary analyses of RCTs in the 2012 PCO, published from March 2010 to January 2016. Results The guideline update reflects changes in evidence since the previous guideline. Nine RCTs, one quasiexperimental trial, and five secondary analyses from RCTs in the 2012 PCO on providing palliative care services to patients with cancer and/or their caregivers, including family caregivers, were found to inform the update. Recommendations Inpatients and outpatients with advanced cancer should receive dedicated palliative care services, early in the disease course, concurrent with active treatment. Referral of patients to interdisciplinary palliative care teams is optimal, and services may complement existing programs. Providers may refer family and friend caregivers of patients with early or advanced cancer to palliative care services.
Rebound Thrombocytosis Is an Independent Predictor of Good Prognosis in AML Patients Attaining First Complete Remission
Authors: Umit Yavuz Malkan, Gursel Gunes, Hakan Goker, Eylem Eliacik, Ayse Isik, Nilgun Sayinalp, Ibrahim Celalettin Haznedaroglu, Haluk Demiroglu, Salih Aksu, Osman Ilhami Ozcebe, Muruvvet Seda Balaban, Tuncay Aslan, Sezgin Etgul, Yahya Buyukasik
Journal: Blood (2014)
P0704 : Deep-sequencing analysis demonstrates the persistence of the pre-transplant HCV dominant variant within a more homogeneous quasispecies after liver transplantation in cholestatic hepatitis C patients
Authors: M. Gambato, J. Gregori, J. Quer, N. Caro-Perez, P. Gonzalez, D. Garcia-Cehic, J.I. Esteban, G. Crespo, M. Navasa, X. Forns, S. Perez-del-Pulgar
Journal: Journal of Hepatology (2015)
Nutrition and the gut microbiome in the elderly
Authors: Nuria Salazar, Lorena Valdés-Varela, Sonia González, Miguel Gueimonde, Clara G. de los Reyes-Gavilán
Journal: Gut Microbes (2016)

The gut microbiota is the assembly of microorganisms living in our intestine and their genomes are known as the microbiome. The correct composition and functionality of this microbiome is essential for maintaining a "healthy status." Aging is related to changes in the gut microbiota which are frequently associated with physiological modifications of the gastrointestinal tract, as well as, to changes in dietary patterns, together with a concomitant decline in cognitive and immune function, all together contributing to frailty. Therefore, nutritional strategies directed at restoring the microbiota in the elderly have to be addressed from a global perspective, considering not only the microbiota but also other extra-intestinal targets of action. The present review aims at summarizing the current knowledge on intestinal microbiota alterations and other functions impaired in the elderly and to analyze tools for implementing nutritional strategies, through the use of probiotics, prebiotics or specific nutrients in order to counterbalance such alterations.
A Retrospective Comparison of Tacrolimus Vs. Cyclosporine for Immunosuppression After Allogeneic Hematopoietic Cell Transplantation with G-CSF-Mobilized Blood Cells
Authors: Yoshihiro Inamoto, Mary E.D. Flowers, Frederick R. Appelbaum, Paul A. Carpenter, H. Joachim Deeg, Kristine C. Doney, Terrence Furlong, Hans-Peter Kiem, Stephanie J. Lee, Marco Mielcarek, Richard A. Nash, Rainer F. Storb, Robert P. Witherspoon, Barry E. Storer, Paul J. Martin
Journal: Blood (2010)
In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors
Authors: Maximilian Richter, Kamola Saydaminova, Roma Yumul, Rohini Krishnan, Jing Liu, Eniko-Eva Nagy, Manvendra Singh, Zsuzsanna Izsvák, Roberto Cattaneo, Wolfgang Uckert, Donna Palmer, Philip Ng, Kevin G. Haworth, Hans-Peter Kiem, Anja Ehrhardt, Thalia Papayannopoulou, André Lieber
Journal: Blood (2016)
Identification of phenotypic clusters of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease
Authors: H. Y. Lee, Y. M. Ye, S. H. Kim, G. Y. Ban, S. C. Kim, J. H. Kim, Y. S. Shin, H. S. Park
Journal: Allergy (2016)

Clinical presentation of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters to determine NERD subtypes.We performed two-step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a NERD cohort comprising 302 patients. Asthma exacerbation was defined as receiving at least one burst of intravenous steroid treatment and/or at least two bursts of oral steroid use (≥ 45 mg/3 days) per year. The possession rate of anti-asthmatic medications was estimated during the follow-up period.There were four subtypes: subtype 1 (NERD with CRS/atopy and no urticaria), subtype 2 (NERD with CRS and no urticaria/atopy), subtype 3 (NERD without CRS/urticaria), and subtype 4 (NERD with urticaria). Significant differences were found between the four subtypes in the female proportion, baseline FEV1%, serum total IgE level, and sputum/peripheral eosinophil count. A higher frequency of asthma exacerbations was noted in subtype 1 compared to subtype 3. The possession rates of medium- to high-dose inhaled corticosteroids/long-acting beta2 -agonists showed significant differences among the four subtypes. Metabolomic analysis showed that the four subtypes of NERD had a higher serum leukotriene E4 (LTE4) level than those with aspirin-tolerant asthma. The patients with subtypes 1 and 3 had a higher urine LTE4 level than those with subtype 2.We found four distinct subtypes with different clinical/biochemical findings and asthma exacerbations in a NERD cohort. These findings suggest that stratified strategies by applying subtype classification may help achieve better outcomes in the management of NERD.
Transfused Myelodysplastic Syndromes (MDS) Patients Have Severe Iron Overload and Relevant Improvements in Iron Burden and Liver Function with Deferasirox Treatment: Results From a Pooled Analysis
Authors: Norbert Gattermann, Peter L. Greenberg, Akio Urabe, Dany Habr, Euloge E. Kpamegan, John B. Porter
Journal: Blood (2011)
Persistent Molecular Remission in Patients Treated with Imatinib-IFNa Combination or Imatinib Monotherapy.
Authors: Monica Schippa, Enrico Gottardi, Debora Luzi, Lorenzo Falchi, Rita Emili, Ilaria Angeletti, Giorgia Desantis, Erminia Gentileschi, Paola Cerroni, Anna Marina Liberati
Journal: Blood (2006)
Unsupervised Analysis of Gene Expression Profile of 37 Human Myeloma Cell Lines Identifies 5 Classes of HMCL Characterized by a Set of 213 Genes Related to Molecular Classification of Patients with Multiple Myeloma
Authors: Jerome Moreaux, Bernard Klein, Thierry Reme, Michel Jourdan, Sophie Maiga, Régis Bataille, Martine Amiot, Catherine Pellat-Deceunynck
Journal: Blood (2008)
Survival Outcomes for Patients (Pts) with Chronic Myeloid Leukemia (CML) with Clonal Evolution (CE) Treated with 2nd Generation Tyrosine Kinase Inhibitors (TKI) after Imatinib Failure.
Authors: Dushyant Verma, Hagop Kantarjian, Zeev Estrov, Guillermo Garcia-Manero, Charles Koller, Gautam Borthakur, Jorge Cortes
Journal: Blood (2007)
RPS19 Deficiency Leads to GATA1 Downregulation through TNF-Mediated p38 MAPK Activation
Authors: Minyoung Youn, Elena Bibikova, Nadia Danilova, Yukako Ono-Uruga, Yoan Konto-Ghiorghi, Rachel Ochoa, Anupama Narla, Bertil Glader, Shuo Lin, Kathleen Sakamoto
Journal: Blood (2014)
MicroRNA Expression Profiling in Sorted AML Subpopulations: A Possible Role for miR-155/BIC in Stem Cell Maintenance and Leukemogenesis.
Authors: Eric R. Lechman, Kristin J. Hope, Fernando J. Suarez Saiz, Katsuto Takenaka, Carlo M. Croce, Mark D. Minden, John E. Dick
Journal: Blood (2005)
Different Response Patterns to Inactivated, Subunit or Live Attenuated Vaccines in Children after Treatment for Malignancies and Bone Marrow Transplantation
Authors: Sema S Anak, Elif Erdem Ozcan, Ayse Kilic, Mustafa Onel, Ayhan Ozguven, Aysegul Unuvar, Zeynep Karakas, Gulyuz Ozturk, Ali Agacfidan, Omer Devecioglu, Leyla Agaoglu, Yurdanur Kilinc
Journal: Blood (2015)
Costs and Consequences Associated With Misdiagnosed Lower Extremity Cellulitis
Authors: Qing Yu Weng, Adam B. Raff, Jeffrey M. Cohen, Nicole Gunasekera, Jean-Phillip Okhovat, Priyanka Vedak, Cara Joyce, Daniela Kroshinsky, Arash Mostaghimi
Journal: JAMA Dermatology (2016)

Inflammatory dermatoses of the lower extremity are often misdiagnosed as cellulitis (aka "pseudocellulitis") and treated with antibiotics and/or hospitalization. There is limited data on the cost and complications from misdiagnosed cellulitis.To characterize the national health care burden of misdiagnosed cellulitis in patients admitted for treatment of lower extremity cellulitis.Cross-sectional study using patients admitted from the emergency department (ED) of a large urban hospital with a diagnosis of lower extremity cellulitis between June 2010 and December 2012. Patients who were discharged with a diagnosis of cellulitis were categorized as having cellulitis, while those who were given an alternative diagnosis during the hospital course, on discharge, or within 30 days of discharge were considered to have pseudocellulitis. A literature review was conducted for calculation of large-scale costs and complication rates. We obtained national cost figures from the Medical Expenditure Panel Survey (MEPS), provided by the Agency for Healthcare Research and Quality (AHRQ) for 2010 to calculate the hospitalization costs per year attributed to misdiagnosed lower extremity pseudocellulitis.The exposed group was composed of patients who presented to and were admitted from the ED with a diagnosis of lower extremity cellulitis.Patient characteristics, hospital course, and complications during and after hospitalization were reviewed for each patient, and estimates of annual costs of misdiagnosed cellulitis in the United States.Of 259 patients, 79 (30.5%) were misdiagnosed with cellulitis, and 52 of these misdiagnosed patients were admitted primarily for the treatment of cellulitis. Forty-four of the 52 (84.6%) did not require hospitalization based on ultimate diagnosis, and 48 (92.3%) received unnecessary antibiotics. We estimate cellulitis misdiagnosis leads to 50 000 to 130 000 unnecessary hospitalizations and $195 million to $515 million in avoidable health care spending. Unnecessary antibiotics and hospitalization for misdiagnosed cellulitis are projected to cause more than 9000 nosocomial infections, 1000 to 5000 Clostridium difficile infections, and 2 to 6 cases of anaphylaxis annually.Misdiagnosis of lower extremity cellulitis is common and may lead to unnecessary patient morbidity and considerable health care spending.
Diagnostic accuracy of the Berlin questionnaire, STOP-BANG, STOP, and Epworth sleepiness scale in detecting obstructive sleep apnea: A bivariate meta-analysis
Authors: Hsiao-Yean Chiu, Pin-Yuan Chen, Li-Pang Chuang, Ning-Hung Chen, Yu-Kang Tu, Yu-Jung Hsieh, Yu-Chi Wang, Christian Guilleminault
Journal: Sleep Medicine Reviews (2016)
Brentuximab Vedotin Followed By Allogeneic Stem-Cell Transplantation for Patients with CD30 Anaplastic or T Cell Non Hodgkin Lymphomas: A Study on Behalf of the SFGM-TC.
Authors: Sylvain Garciaz, Michael Loschi, Adele de Masson, Sylvie François, Cecile Tomowiak, Nathalie Fegueux, Hélène Labussière-Wallet, David Sibon, Ophelie Cassuto, Cecile Borel, Jérôme Cornillon, Stanislas Nibumona, Amandine Charbonnier, Pauline Brice, Gerard Socie, Didier Blaise, Regis Peffault de la Tour, Flore Sicre de Fontbrune
Journal: Blood (2015)
The Detection of Multilineage Dysplasia (MLD) Has No Influence on Prognosis in NPM1 Mutated Acute Myeloid Leukemia (AML) with Normal Karyotype
Authors: Ulrike Bacher, Susanne Schnittger, Wolfgang Kern, Tamara Weiss, Claudia Haferlach, Brunangelo Falini, Torsten Haferlach
Journal: Blood (2008)
MiR-34a Replacement As a Novel Therapeutic Approach for Multiple Myeloma: Preclinical In Vitro and In Vivo Evidence
Authors: Maria Teresa Di Martino, Emanuela Leone, Nicola Amodio, Umberto Foresta, Marta Lionetti, Maria Rita Pitari, Maria Eugenia Gallo Cantafio, Annamaria Gullà, Eugenio Morelli, Marzia Leotta, Vera Tomaino, Marco Rossi, Massimo Negrini, Manlio Ferrarini, Antonino Neri, Kenneth C. Anderson, Nikhil C. Munshi, Pierosandro Tagliaferri, Pierfrancesco Tassone
Journal: Blood (2011)
Upregulation of Interferon-Inducible and Damage Response Receptors in Chronic Graft-Versus-Host Disease
Authors: Frances T. Hakim, Sarfraz Memon, Ping Jin, Matin M. Imanguli, Najibah Rehman, Xiao-Yi Yan, Jeremy J. Rose, Jacqueline W. Mays, Susan Dhamala, Veena Kapoor, William Telford, David C. Halverson, Kristin Baird, Daniel H. Fowler, David Stroncek, Edward W. Cowen, Steven Z. Pavletic, Ronald E. Gress
Journal: Blood (2015)
High Dose Therapy and Autologous Peripheral Blood Stem Cell Transplantation as Salvage Therapy for HIV-Associated Lymphoma: Result of the GICAT Study.
Authors: Alessandro Re, Mariagrazia Michieli, Chiara Cattaneo, Maurizio Rupolo, Salvatore Casari, Michele Spina, Bernardino Allione, Camillo Almici, Piero Ferremi, Luciano Abruzzese, Cecilia Simonelli, Rosa Manuele, Alessandro Levis, Giampiero Carosi, Umberto Tirelli, Giuseppe Rossi
Journal: Blood (2007)
T-Cell Depleted Unrelated Donor Stem Cell Transplants Appear to Be of Value for Adult Philadelphia Chromosome Negative ALL Patients and Should Be Evaluated Prospectively in New Large Group Studies
Authors: B. R Patel, Keiren Kirkland, R. Pearce, Richard E Clark, Charles F. Craddock, Effie Liakopolou, Adele K Fielding, Stephen Mackinnon, Eduardo Olavarria, Michael N Potter, Nigel H. Russell, Bronwen E. Shaw, Anthony H. Goldstone, David I Marks
Journal: Blood (2008)
<i><scp>PTTG</scp>1<scp>IP</scp></i> and <i><scp>MAML</scp>3</i>, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma
Authors: M. A. E. Nieuwenhuis, J. M. Vonk, B. E. Himes, C. Sarnowski, C. Minelli, D. Jarvis, E. Bouzigon, D. C. Nickle, M. Laviolette, D. Sin, S. T. Weiss, M. van den Berge, G. H. Koppelman, D. S. Postma
Journal: Allergy (2016)

The severity of bronchial hyperresponsiveness (BHR) is a fundamental feature of asthma. The severity of BHR varies between asthmatics and is associated with lack of asthma control. The mechanisms underlying this trait are still unclear. This study aimed to identify genes associated with BHR severity, using a genomewide association study (GWAS) on the slope of BHR in adult asthmatics.We performed a GWAS on BHR severity in adult asthmatics from the Dutch Asthma GWAS cohort (n = 650), adjusting for smoking and inhaled corticosteroid use, and verified results in three other cohorts. Furthermore, we performed eQTL and co-expression analyses in lung tissue.In the discovery cohort, one genomewide significant hit located in phosphodiesterase 4D, cAMP-specif (PDE4D) and 26 SNPs with P-values < 1*10-5 were found. None of our findings replicated in adult and childhood replication cohorts jointly. In adult cohorts separately, rs1344110 in pituitary tumour-transforming 1 interacting protein (PTTG1IP) and rs345983 in Mastermind-like 3 (MAML3) replicated nominally; minor alleles of rs345983 and rs1344110 were associated with less severe BHR and higher lung tissue gene expression. PTTG1IP showed significant co-expression with pituitary tumour-transforming 1, the binding factor of PTTG1lP, and with vimentin and E-cadherin1. MAML3 co-expressed significantly with Mastermind-like 2 (MAML2), both involved in Notch signalling.PTTG1IP and MAML3 are associated with BHR severity in adult asthma. The relevance of these genes is supported by the eQTL analyses and co-expression of PTTG1lP with vimentin and E-cadherin1, and MAML3 with MAML2.