tbuckley/cabot-search huggingface dataset:
THU0618-HPR Immediate Effects of Mulligan's Concept Mobilization with Movement on Knee Pain and Functions in Patients with Knee Osteoarthritis
Authors: D. Oskay, H. Altmış, I. Düzgün, B. Elbasan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Knee osteoarthritis (KOA) is a frequent cause of knee pain which can be successfully managed by physiotherapy. Joint mobilization has been shown to be a useful modality to reduce knee pain. Mulligan9s concept of mobilization with movement (MWM) is a contemporary form of joint mobilization, consisting of a therapist-applied pain-free accessory gliding force combined with active movement. There are reports of immediate pain relief and improved function in response to these techniques in several musculoskeletal disorders. <h3>Objectives</h3> To investigate the immediate effect of Mulligan9s concept of MWM and Mulligan taping technique on function and pain in patients with KOA. <h3>Methods</h3> Sixty patients (with the mean age of 59±7,21) with the grade of 2 or 3 KOA according to the Kellegren and Lawrence included into the study. Patients randomly divided into 3 groups. Therapist applied MWM and Mulligan taping technique for group 1, MWM and placebo taping for group 2, just placebo taping for group 3. Demographics, pain severity in the rest, pain severity during the performance of the tests and tests scores before and after the applications (MWM and tapings) of the therapist were recorded for all groups. Functional status assessed with a group of functional tests including lift test (LT), pick-up test (PT), repeated sit-to-stand test (RST), Sock Test, Stair Ascending and Descending Test (SAD), Straight line walking test (SLW), Timed Up &amp; Go Test (TUG). Pain severity was assessed with visual analog scale (VAS). <h3>Results</h3> In all groups there is a significant difference between pain levels and functional test scores before and after the applications (p&lt;0,05). After the applications there is a significant difference between group 1 and 3 in the comparison of the all groups functional tests scores and pain levels during the tests (p&lt;0,05). Additionally after the application of MWM and tapings there is a significant difference between group 1 and 2 just for RST, SAD and SLW scores (p&lt;0,05). <h3>Conclusions</h3> This randomized clinical trial revealed that Mulligan9s Concept is an important method in recovery of knee function and reduction of pain in OA patients. Application of MWM with Mulligan taping is more effected on immediate reduction in pain during the function than only application of MWM. <h3>Disclosure of Interest</h3> None declared
The Pineal Organ
Authors: Richard J. Wurtman, Michael A. Moskowitz
Journal: New England Journal of Medicine (1977)

Other Possible Pineal HormonesIn addition to melatonin, the mammalian pineal contains, and probably releases, two groups of compounds that may have hormonal activity: other methoxyindoles, such as 5-methoxytryptophol; and peptides, such as arginine vasotocin. A full analysis of the evidence supporting their hormonal activities is beyond the scope of this review and is available elsewhere.22,23 Currently, most interest centers on arginine vasotocin, initially proposed as a pineal hormone by Pavel and Petrescu.51 This oxytocic compound is present in whole pineals52 , 53 (but, according to one group of investigators, may be confined to the pineal stalk53). It is reported to . . .
The multiple functions of the state mental hospital
Authors: H H Goldman, C A Taube, D A Regier, M Witkin
Journal: American Journal of Psychiatry (1983)

This report identifies and quantifies the multiple manifest and latent functions of the state mental hospital, using data collected by the National Institute of Mental Health. The data reveal a complex institution providing over 500,000 episodes of care for acute and chronic, voluntarily and involuntarily admitted inpatients and 300,000 episodes of care for the most seriously disturbed and disadvantaged outpatients. In addition, state hospitals employ over 200,000 individuals and train over 3,300 professionals each year. The diversity and significance of these functions, as well as the failure of other institutions to supplant them, account for the endurance of the state mental hospital.
The EVEREST study: relationship between efficacy and K-RAS mutation status in patients with irinotecan-refactory MCRC treated with irinotecan and standard or escalating doses of cetuximab
Authors: S Tejpar, Marc Peeters, Y Humblet, H Gelderblom, J Vermorken, G De Hertogh, W De Roock, J Nippgen, A Von Heyderbreck, C Stroh, E Van Cutsem
Journal: Annals of Oncology (2008)
Multiple Myeloma Cells Express IL-17A Creating An Autocrine Loop: An Attractive Therapeutic Target
Authors: Rao H. Prabhala, Mariateresa Fulcinitti, Dheeraj Pelluru, Harsha K. Prabhala, Naim Rashid, Adam Sperling, Puru Nanjappa, Saem Lee, Andreea Negroiu, Suzan Lazo-Kallanian, Aditya Munshi, Paul G. Richardson, John Daley, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2013)
FRI0465 Animal (PET)-Assisted Therapy Helps in Reducing Pain and Promotes Social-Affective Regulation in Systemic Sclerosis (SSC)
Authors: G. Fiori, F. Bartoli, T. Marzi, M. Galimberti, M. Palomba, E. Corsi, M. Zolferino, C. Ciceroni, M. Matucci Cerinic
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Recently, the affective relationship between humans and animals has shown a potentially beneficial effects in clinical domains. However, the claim of different studies of the benefits of animal-assisted activities (AAA) is still lacking evidence base data. <h3>Objectives</h3> To gain insights into the effectiveness of AAA, physiotherapy and psychological support in SSc. <h3>Methods</h3> 12 SSc female patients (mean age of 60.52±8.3) were treated once a week by a team made of a dog-handler a rheumatologist and a psychologist. They underwent 10 dog-assisted interventions. At onset and after 3 months, the questionnaires and self reports were completed: pain evaluation (VAS 0-100), emotional and affective evaluation (Happy Face-Sad Face Scale), state anxiety (STAI), and a specific designed self report on the liking and satisfaction of the AAA interventions (AAA-Q). <h3>Results</h3> Significant improvements were reported for pain perception, mood, and other measures of distress among patients after AAA. Pain decreased significantly (p&lt;0.05) in 73% of patients (VAS 0-100mm) after AAA (24.99 mm vs 16.18 mm). The regular interaction with dogs has showed to increase positive affective and social behaviors. Specifically, the emotional scale showed a significant enhancement of mood and positive feelings after AAA (1.98 vs 0.66) (p&lt;0.05). We found increase social awareness, promoting social skills reducing anxiety and depressive symptoms (STAI X1-&gt;76±7.5 vs 62±4.3) significantly different before and after AAA (p&lt;0.03). <h3>Conclusions</h3> This is the first study measuring the efficacy of AAA (with dogs) on the physiological, emotional, social well-being and pain perception in SSc. The study provides the evidence for pain control with enhancement of the psychosocial well-being. AAA integrated with the traditional medical approach may provide a good support for SSc patients. <h3>Disclosure of Interest</h3> None declared
AB1031 A Rare Cause of Myopathy: Inflammatory Myopathy with Abundant Macrophages in a Child
Authors: Z. Ekinci, K. Ozturk, Y. Anik
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Inflammatory myopathy with abundant macrophages (IMAM) is a rare and recently discovered clinical condition, which has been proposed as one of the causes of inflammatory myopathy. IMAM is characterized by the diffuse infiltration of macrophages into muscle and fascia with fiber damage. The underlying mechanism responsible for IMAM remains unknown. Severe forms of IMAM might be associated with macrophage activation syndrome (MAS). <h3>Objectives</h3> In this report, a very rare condition, a case of childhood IMAM with MAS is presented. <h3>Methods</h3> An 11-year-old girl was suffering from fever, generalized erythematous rush, severe musculoskeletal pain and edema in lower extremities. Physical examination showed fever causing elevated body temperature up to 40° C, generalized maculopapular rash, swelling, pain and limitation of motion in the legs. Heliotrope rash and Gottron9s papules were not detected. After admission, laboratory tests revealed the following: white blood cell (WBC) count of 3.3x10<sup>3</sup>/μL, platelet (plt) count of 120 x10<sup>3</sup>/μL, C reactive protein (CRP) level of 10.8 mg/dl, lactate dehydrogenase level of 937 U/l, ALT level of 77 U/l, AST level of 194 U/l, creatine kinase (CK) level of 1021 U/l, fibrinogen level of 1.44 g/L, erythrocyte sedimentation rate of 2 mm/h, ferritin level of 3414 ng/ml and triglyceride level of 447 mg/dl. Bone marrow aspiration was performed for differential diagnosis and revealed hemophagocytosis. Bacterial cultures of blood and bone marrow were negative. EBV, CMV, Parvovirus, hepatitis A, B, and C infections were ruled out according to specific Ig G and M levels. Magnetic resonance imaging of lower extremities revealed thickening of the fascia, fasciitis and myositis. <h3>Results</h3> MAS in association with myositis led to the diagnosis of IMAM. The patient was treated with intravenous methylprednisolone (30 mg/kg/day) for three days. On third day of treatment, fever, rash and swelling of legs subsided. At the end of the first week, patient was discharged with prednisolone and did not show a relapse of symptoms thereafter. <h3>Conclusions</h3> As far as we know, this is the first reported IMAM case with MAS during childhood. It should be kept in mind that, in the evaluation phase of inflammatory myositis, laboratory findings of MAS should be searched for. <h3>References</h3> Fujikawa K, Migita K, Shigemitsu Y, Umeda M, Nonaka F, Tamai M, et al. MEFV gene polymorphisms and TNFRSF1A mutation in patients with inflammatory myopathy with abundantmacrophages. Clin Exp Immunol. 2014 Nov;178:224-8. Hara S, Henmi T, Kawakami A, Fujikawa K, Mukae H, Ishimatsu Y, et al. Clinical, serologic and magnetic resonance imaging of 3 cases of inflammatory myopathy with abundantmacrophages in the Japanese population. Rheumatol Int. 2013 Apr;33:1059-64. <h3>Disclosure of Interest</h3> None declared
Comparative Fluorescein Labeling and Cytotoxicity Studies With Human Cell Strains HeLa, Raos, and 407-Liver and With Fresh Surgical Specimens of Cervical Carcinoma, Osteogenic Sarcoma, and Normal Adult Liver
Authors: M N GOLDSTEIN, R HIRAMOTO, D PRESSMAN
Journal: JNCI Journal of the National Cancer Institute (1959)
Economic analysis of epicup, an epigenetic test to predict the tissue of origin in cancer of unknown primary site.
Authors: Carmen Balana, Alfredo Gracia, Lisette Kaskens, Sebastian Chiavenna, Xavier Matias-Guiu, Dario Rubio-Rodriguez, Carlos Rubio-Terres, Lara Iglesias, Manel Esteller
Journal: Journal of Clinical Oncology (2015)

e12532 Background: To estimate the clinical and economic trade-offs involved in using the molecular assay EPICUP to aid in identifying the primary site of difficult-to-diagnose metastatic cancers. Methods: A decision-analytic model was developed to estimate the lifetime clinical and economic outcomes of incorporating the EPICUP assay compared with standard care and other molecular assays (CancerTYPE ID, Cancer Origin Test and ResponseDX Tissue of Origin Test). The analysis was limited to 3 primary cancer sites (breast, colon, pancreatic carcinoma) for adenocarcinoma histological subtype. Results are presented as incremental cost-effectiveness ratio (ICER, cost per quality-adjusted life-years [QALY] gained) from the Spanish National Health System perspective. Model inputs were based on a case-control study of EPICUP, published literature, Surveillance Epidemiology and End Results database, and a panel of clinical experts. Results: Based on a price of €3,000 ($3,391) for EPICUP, this would be the cost-effective ( vs. CancerTYPE ID, Cancer Origin Test) or dominant option (more effective and with lower costs than Response DX) in all carcinomas analyzed. EPICUP increased the proportion of patients treated correctly, decreased the proportion of patients treated with empiric therapy, and increased quality-adjusted survival. Regarding the comparison with standard care, the ICER was €15,882 ($17,958) for breast cancer, €25,858 ($29,393) for colon cancer and €35,374 ($40,199) for pancreatic cancer. These findings were robust across deterministic and probabilistic sensitivity analyses. Conclusions: Use of EPICUP assay for diagnosing metastatic tumors of uncertain origin is a cost-effective approach to standardizing diagnostic methods while improving patient care.
Immunization with Live Measles Virus Vaccine.
Authors: H R BRODIE
Journal: JAMA (1963)

One hundred and fifty children who had no measurable serum measles antibody were vaccinated with live measles virus. All showed post-vaccinal serum antibody levels generally considered sufficient to prevent measles.One hundred and thirty-nine (93%) of the infants and children demonstrated one or more symptoms following vaccination. In view of their generally mild and limited nature, and of the protection subsequently afforded, this procedure would seem to be a real advance in preventive medicine.
PTU-278 Transanal endoscopic microsurgey: the impact of colorectal cancer screening on patient demographics and pathological characteristics in a single cent\\re
Authors: M Proctor, GE Ekatah, A Stewart, CT Reddy, DN Anderson, D Speake
Journal: Gut (2015)

<h3>Introduction</h3> The Bowel Screening Programme aims to detect polyps and cancers at an earlier stage, many of these lesions are early rectal cancers or polyps not amenable to endoscopic therapy. Surgical Resection carries significant morbidity; consequently Transanal Endoscopic MicroSurgery (TEMS) has gained popularity. We investigate the impact of screening on TEMS activity in a single centre. <h3>Method</h3> Data on all patients undergoing TEMS for rectal lesions between 2010 and 2014 was prospectively collected. Patient characteristics and TEMS pathological data were investigated. Statistical analysis was carried out using independent T-test and Chi Square analysis. <h3>Results</h3> It total, 97 patients underwent TEMS resection for rectal lesions, 18 of which had evidence of cancer. There was no difference in the proportions of malignancies in those identified through screening (n = 5 (17%); pT1 (n = 2), pT2 (n = 2), pT3 (n = 1)) when compared to the non-screening cohort (n = 13 (19%); pT1 (n = 7), pT2 (n = 4), pT3 (n = 2)). Patients identified through the screening process (n = 29, 30%) were younger (mean 66–71, p = 0.04), had smaller benign lesions (maximal diameter mean 34 mm to 48 mm, p = 0.012) and smaller cancers (maximal diameter mean 22 mm to 41 mm, p = 0.04). <h3>Conclusion</h3> Screen detected rectal lesions account for approximately a third of all those TEMS procedure performed in a single unit. Patients detected through screening were younger with smaller lesions. The advent of screening has increased work load for TEMS and this demand on the service is likely to increase in the future. <h3>Disclosure of interest</h3> None Declared.
Enhanced Survival and Absence of Progressive Growth of Transplanted Rat Liver Altered Eosinophilic Foci and Neoplastic Nodules in Phenobarbital-Treated Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: H Mori, K Furuya, G M Williams
Journal: JNCI Journal of the National Cancer Institute (1983)

Hepatocellular altered eosinophilic cell foci and neoplastic nodules induced in inbred F344 male albino rats by the feeding of N-2-fluorenylacetamide were transplanted into the inguinal mammary fat pads of syngeneic animals to assess their ability to produce neoplasms. Treatment of one-half of the recipients with the neoplasm promoter phenobarbital sodium enhanced survival of both types of transplants. However, at the end of 6 or 12 months of maintenance of recipients of altered foci and 6 months of maintenance of recipients of early and late nodules, no neoplasms occurred, in spite of persistence of abnormal cells at the transplant sites. Therefore, the conclusion was that these carcinogen-induced liver lesions possess limited growth capacity in this ectopic site and that transition to carcinoma under these conditions did not occur in high frequency.
Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes
Authors: Rongrong Fan, Amine Toubal, Saioa Goñi, Karima Drareni, Zhiqiang Huang, Fawaz Alzaid, Raphaelle Ballaire, Patricia Ancel, Ning Liang, Anastasios Damdimopoulos, Isabelle Hainault, Antoine Soprani, Judith Aron-Wisnewsky, Fabienne Foufelle, Toby Lawrence, Jean-Francois Gautier, Nicolas Venteclef, Eckardt Treuter
Journal: Nature Medicine (2016)
Ehrlichiosis
Authors: C Glaser, E Johnson
Journal: New England Journal of Medicine (1995)

Figure 1. Intraleukocytic inclusion bodies of ehrlichia species are visible in buffy-coat smears from a 13-year-old girl with fever, encephalitis, neutropenia, and disseminated intravascular coagulation (×1000). The arrows in Panel A and Panel B show the classic mulberry-like structures, or morulae; the arrow in Panel C shows an immature inclusion body. The patient had been bitten by ticks on a recent trip to Arkansas. The diagnosis of ehrlichiosis was made on the basis of these smears and later confirmed by serologic studies.
Caffeine augmentation of ECT
Authors: C E Coffey, G S Figiel, R D Weiner, W B Saunders
Journal: American Journal of Psychiatry (1990)

In a randomized, double-blind, placebo-controlled pilot study of 40 depressed inpatients, the authors compared two techniques for maintaining seizure duration during pulse unilateral ECT: pretreatment with intravenous caffeine versus electrical stimulus intensity dosing. Both techniques effectively maintained seizure duration, but with caffeine this was accomplished without any increase in mean stimulus intensity over the course of ECT. There were no differences between the two techniques in therapeutic outcome or cognitive side effects from ECT, and caffeine pretreatment was well tolerated. The authors discuss the clinical and research implications of these findings with respect to strategies for maintaining seizure duration during ECT.
Schwannoma of the Common Bile Duct: A Rare Cause of Obstructive Jaundice
Authors: R.  Jakobs, J.  Albert, D.  Schilling, T.  Nuesse, J.  F.  Riemann
Journal: Endoscopy (2003)

The endoscopic diagnosis of bile duct lesions has improved over recent years through the introduction of cholangioscopy and intraductal ultrasound. Combining this with biopsies examined using routinely administered immunohistochemical markers, the diagnosis of tumors of the extrahepatic bile duct can be improved substantially. We report a rare case of a schwannoma of the bile duct causing obstructive jaundice.
A simple ex vivo, biologic ERCP training model for sphincterotomy
Authors: Nadan Rustemovic, Marco D’Assuncao, Branko Bilic, Hrovje Ivekovic, Benjamin Hewitt, Ivan Jovanovic, Klaus Mönkemüller
Journal: Endoscopy (2015)

The key therapeutic intervention during endoscopic retrograde cholangiopancreatography (ERCP) is sphincterotomy, but lack of training and experience leads to a higher risk of complications [1] [2]. Herein, we present a simple, reproducible, easy-to-build, ex vivo, ERCP model for the training of sphincterotomy using standard sphincterotomes and a needle knife.
The effect of uninephrectomy on progression of renal failure in autosomal dominant polycystic kidney disease.
Authors: M Zeier, S Geberth, A Gonzalo, D Chauveau, J P Grünfeld, E Ritz
Journal: Journal of the American Society of Nephrology (1992)

The evolution of renal failure was compared in 47 patients (21 male, 26 female) with autosomal dominant polycystic kidney disease (ADPKD) in Germany, France, Spain, and Portugal who had undergone uninephrectomy (UNX) (median age at uninephrectomy, 41 yr; range, 22 to 54) and 47 non-UNX matched controls. UNX was usually performed because of uncontrolled urinary tract infection (N = 30), stones (N = 8), trauma (N = 2), or hemorrhage (N = 7). Median serum creatinine at UNX was 2.1 mg/dL (0.9 to 4.3). Twenty-eight of the 47 uninephrectomized patients progressed to end-stage renal failure. When the age at renal death was evaluated by survival analysis, only minor and nonsignificant acceleration was seen in the uninephrectomized patients (median, 50 yr; p25 = 43.6 yr; p75 = 58.3 yr, where p is the percentile) compared with non-UNX patients matched for age, sex, and serum creatinine at the time of UNX in the propositus (51.2 yr; p25 = 48.6 yr; p75 = 56.1 yr). In addition, the median interval for serum creatinine to rise from 4 to 8 mg/dL was similar in UNX (21.3 months) versus nonuninephrectomized ADPKD patients (21.9 months). Renal survival differed in the two genders. In females, no significant difference of age at renal death was found between UNX (median age, 51.6 yr) and non-UNX ADPKD patients (53.7 yr). In male UNX patients, age at renal death was slightly (but not significantly) less than in non-UNX patients (median age, 47.3 versus 52.7 yr). All male patients reaching end-stage renal failure before age 44 were severely hypertensive.
SAT0486 Reference Intervals for Bone Turnover Markers in Spanish Premenopausal Women
Authors: N. Guañabens, X. Filella, A. Monegal, C. Gomez-Vaquero, M. Bonet, D. Buquet, E. Casado, D. Cerda, A. Erra, S. Martinez, N. Montala, C. Pitarch, E. Kanterewicz, M. Sala, X. Suris, F. Torres
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Bone turnover markers (BTMs) are used in clinical practice for assessing patients with osteoporosis and their treatment. In Spain it is necessary to fine-tune the reference intervals, since they were established years ago in a low number of individuals. <h3>Objectives</h3> The aims of this study were to establish robust reference intervals for BTMs in healthy young premenopausal Spanish women and to investigate the factors influencing BTMs. <h3>Methods</h3> 185 women aged 35 to 45 yrs. from 13 centres in Catalonia were recruited. Blood and second void urine samples were collected between 8 and 10 a.m. after an overnight fast. Serum PINP and βCTX were measured by two automated methods (Elecsys, Roche<sup>a</sup> and IDS-ISYS, Immunodiagnostic Systems<sup>b</sup>), bone ALP by ELISA (IDS, Vitro), osteocalcin by IRMA (Cis Bio) and urinary NTX by ELISA (Osteomark, Vitro). PTH and 25OHD levels were measured in all participants, who completed a questionnaire on lifestyle factors. A quantile regression was fit to estimate the 5%, 50% and 95% percentiles for the BMTs, and the Fisher9s exact test and non-parametric tests were used to assess the influence of factors on BTMs. <h3>Results</h3> The median (P5-P95) for BTMs were: Bone ALP 9.3 (6.0-13.8) ng/ml, PINP<sup>a</sup> 35.9 (20.8-60.6) ng/ml, PINP<sup>b</sup> 35.8 (20.8-64.9) ng/ml, NTX 32.7 (19.3-68.9) nM/mM, CTX<sup>a</sup> 0.250 (0.137-0.480) ng/ml, CTX<sup>b</sup> 0.246 (0.107-0.541), Osteocalcin 14.0 (8.0-23.0) ng/ml. Oral contraceptive pills (OCPs) were reported in 10.9% of participants, mean BMI was 23 and 60% had 25OHD levels lower than 20 ng/ml. Women on OCPs had lower PINP levels (p=0.007).25OHD levels didn9t influence BTMs, but low BMI was associated with higher levels of almost all BTMs. <h3>Conclusions</h3> In conclusion, robust reference intervals for BTMs in a southern European country are provided. <h3>Acknowledgements</h3> This study was funded by a research grant from de Societat Catalana de Reumatologia. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1755
Induction of Ovarian Neoplasms Following Intrasplenic Transplantation of Ovarian Grafts to Old Castrated Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;3&lt;/xref&gt;
Authors: M KLEIN
Journal: JNCI Journal of the National Cancer Institute (1953)