Sex-Specific Research: A Key Component in Improving Prognosis After Transcatheter Aortic Valve Replacement
Authors: Nina Johnston, Christina Christersson
Journal: Annals of Internal Medicine (2016)

Editorials15 March 2016Sex-Specific Research: A Key Component in Improving Prognosis After Transcatheter Aortic Valve ReplacementNina Johnston, MD, PhD and Christina Christersson, MD, PhDNina Johnston, MD, PhDFrom Uppsala University, Uppsala, Sweden.Search for more papers by this author and Christina Christersson, MD, PhDFrom Uppsala University, Uppsala, Sweden.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0105 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Aortic stenosis (AS) is the most common valvular heart disease requiring valve replacement. It is a progressive disease that has life-threatening consequences and severely affects quality of life. Among persons older than 80 years, the prevalence of AS is as high as 10% (1), and that number is expected to increase as life expectancy increases. Because women generally outlive men, many women develop AS.Medical treatment of symptomatic AS is often difficult and insufficient. Health care costs are high, and palliative end-stage measures are not uncommon. Surgical aortic valve replacement (SAVR) alleviates symptoms and improves survival and quality of life. ...References1. Regitz-Zagrosek V, Oertelt-Prigione S, Prescott E, Franconi F, Gerdts E, Foryst-Ludwig A, et al; EUGenMed. Gender in cardiovascular diseases: impact on clinical manifestations, management, and outcomes. Eur Heart J. 2016;37:24-34. [PMID: 26530104] doi:10.1093/eurheartj/ehv598 CrossrefMedlineGoogle Scholar2. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Barón-Esquivias G, Baumgartner H, et al; ESC Committee for Practice Guidelines (CPG). Guidelines on the management of valvular heart disease (version 2012): the Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). Eur J Cardiothorac Surg. 2012;42:S1-44. [PMID: 22922698] doi:10.1093/ejcts/ezs455 CrossrefMedlineGoogle Scholar3. Panchal HB, Ladia V, Desai S, Shah T, Ramu V. A meta-analysis of mortality and major adverse cardiovascular and cerebrovascular events following transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis. Am J Cardiol. 2013;112:850-60. [PMID: 23756547] doi:10.1016/j.amjcard.2013.05.015 CrossrefMedlineGoogle Scholar4. Williams M, Kodali SK, Hahn RT, Humphries KH, Nkomo VT, Cohen DJ, et al. 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Lerakis S, Hayek SS, Douglas PS. Paravalvular aortic leak after transcatheter aortic valve replacement: current knowledge. Circulation. 2013;127:397-407. [PMID: 23339094] doi:10.1161/CIRCULATIONAHA.112.142000 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Uppsala University, Uppsala, Sweden.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0105.Corresponding Author: Nina Johnston, MD, PhD, Department of Medical Sciences, Cardiology, Uppsala University, Akademiska Sjukhuset, 751 85 Uppsala, Sweden.Current Author Addresses: Drs. Johnston and Christersson: Department of Medical Sciences, Cardiology, Uppsala University, Akademiska Sjukhuset, 751 85 Uppsala, Sweden.This article was published at www.annals.org on 23 February 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoSex-Specific Differences at Presentation and Outcomes Among Patients Undergoing Transcatheter Aortic Valve Replacement Susheel Kodali , Mathew R. Williams , Darshan Doshi , Rebecca T. Hahn , Karin H. Humphries , Vuyisile T. Nkomo , David J. Cohen , Pamela S. Douglas , Michael Mack , Ke Xu , Lars Svensson , Vinod H. Thourani , E. Murat Tuzcu , Neil J. Weissman , Martin Leon , and Ajay J. Kirtane Metrics 15 March 2016Volume 164, Issue 6Page: 442-443KeywordsAortic valve replacementDisclosureHemorrhageMortalityQuality of lifeStenosisSurgeonsSurgeryValve replacementValvular diseases ePublished: 23 February 2016 Issue Published: 15 March 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...