tbuckley/cabot-search huggingface dataset:
AB0668 A Pilot Study of the Eicosapentaenoic Acid/Arachidonic Acid (EPA/AA) Ratio Level of Japanese Patients with Behçet's Disease
Authors: T. Kobashigawa, Y. Nanke, H. Yamanaka, S. Kotake
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Kürkçüoğlu (1) reported for the first time for the efficacy of eicosapentaenoic acid (EPA) to the patients of Behçet9s disease (BD). In Japan, the anti-inflammatory efficacy of EPA to the patients with BD was reported (2, 3). Recently, low level of EPA/AA ratio protecting the events of coronary artery disease was reported in Japan (4, 5). The level of EPA/AA ratio in the patients with BD was not elucidated in the daily clinical practice. <h3>Objectives</h3> To investigated the relationships between states of BD and the level of EPA/AA ratio of the patients with BD in daily medical practice. <h3>Methods</h3> We analyzed the levels of EPA/AA ratio in 25 patients with BD. The examinations of fatty acid fractions were performed in a daily general blood survey. We keep the regulation of medical insurance for the whole nation. The disease activity was shown with the score of patient9s global assessment VAS (PtGA), in this study. Our hypothesis was that the level of EPA/AA ratio is decreased in the vascular-BD patients as for an anti-inflammation and anti-vasculitis. <h3>Results</h3> We analyzed 25 patients with BD who visited our clinic in resent 2 years from 2012 to 2013. The characteristics of 25 patients with BD were as shown below: oral lesions were shown in all 25 patients with BD, skin lesions in 24, genital ulcers in 19, ocular lesions in 10, arthritis in 19, intestinal lesions in 11, neural lesions in 3 and vascular lesions in 5. The total 3 times were analyzed in this study, thus the characteristics of our total patients were below: oral lesion 75, skin lesions 71, genital ulcer 61, ocular lesions 26, arthritis 59, intestinal lesions 40, neural lesions 9 and vascular 19, and the average of EPA/AA ratio was 0.41 (SD =0.30). We participated this 75 into 3 categories: 19 were over the normal EPA/AA ratio (0.11 – 0.5), 54 were within the normal ratio and 2 were under the normal ratio. Also the mean EPA/AA ratio (SD) were 0.84 (0.29), 0.27 (0.097) and 0.077 (0.0011), respectively. Our hypostasis was confirmed, and the 2 patients of under the standard value of EPA/AA/ratio were same one patients who was an intestinal-BD patient and had sever digestive symptoms at the time. The decrease in-take was the cause of the decreasing EPA/AA ratio. <h3>Conclusions</h3> The level of EPA/AA ratio was not related the activities in the Japanese vascular-BD patients. <h3>References</h3> Kürkçüoğlu, N. and Tandoğdu, R: Brit J Dermatol. 121: 667-8, 1989. Annual report of the Behçet9s Disease Research Committee of Japan. 185-7, 1992. Annual report of the Behçet9s Disease Research Committee of Japan. 160-2, 1993. Yokoyama M, et al. Lancet 2007: 369. 1090-8. Ninomiya T, et al. Atherosclerosis. 2013; 231. 261-7. <h3>Disclosure of Interest</h3> None declared
Low levels and lack of function of muscarinic binding sites in human skin fibroblasts from five affectively ill patients and two control subjects
Authors: S C Lin, E Richelson
Journal: American Journal of Psychiatry (1986)

Skin fibroblasts of five subjects with affective illness and two control subjects were examined for muscarinic receptors. Contrary to recent findings, there were low levels of muscarinic binding sites and no evidence that these sites mediate a biological response.
Start stopping smartly
Authors: Fiona Godlee
Journal: BMJ (2016)

There can be little that’s more central to a doctor’s role than clearly communicating the benefits and harms of treatments. Yet it’s one of the hardest things to get right, and it seems to be getting harder. Approaches once considered adequate no longer meet the needs of shared decision making or the complexity of the evidence base. At a meeting last week at the Academy of Medical Sciences delegates agreed that doctors, patients, journalists, and the public often struggled to grasp numerical …
Pseudoepilepsy: a study in adolescent hysteria
Authors: M Gross
Journal: American Journal of Psychiatry (1979)

Of 19 adolescents with diagnosed psychogenic seizures, 13 had hysterical convulsions and 4 had amnesiac fugues. Sixteen of the patients were given a diagnosis of hysterical neurosis; 2, process schizophrenia; and 1, borderline psychosis. Thirteen of the patients were initially diagnosed incorrectly as having epilepsy and were treated for an average of 15 months with anticonvulsant medication. The therapist should always consider the possibility of psychogenic factors in children and adolescents who suffer from seizures.
Vascular Reactions of Normal and Malignant Tissues &lt;italic&gt;in Vivo&lt;/italic&gt;. V. The Rôle of Hypotension in the Action of a Bacterial Polysaccharide on Tumors
Authors: Glenn H. Algire, Frances Y. Legallais, Belle F. Anderson
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Vascular Reactions of Normal and Malignant Tissues in Vivo. V. The Rôle of Hypotension in the Action of a Bacterial Polysaccharide on Tumors Get access Glenn H. Algire, Glenn H. Algire National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Frances Y. Legallais, Frances Y. Legallais National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Belle F. Anderson Belle F. Anderson National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1279–1295, https://doi.org/10.1093/jnci/12.6.1279 Published: 01 June 1952 Article history Received: 26 February 1952 Published: 01 June 1952
PWE-077 Outcome following resection of biliary cystadenoma – a single centre experience
Authors: M Pitchaimuthu, G Aidoo-Micah, C Coldham, R Sutcliffe, K Roberts, P Muiesan, J Isaac, D Mirza, R Marudanayagam
Journal: Gut (2015)

<h3>Introduction</h3> Biliary cystadenoma (BCA) are rare, benign, potentially malignant cystic lesions of the liver, accounting for less than 5% of cystic liver tumours. These lesions have potential for recurrence and malignant transformation. The aim of the study was to analyse the outcome following resection of biliary cystadenoma from a single tertiary centre. <h3>Method</h3> Patients who had resection of BCA between 1993 and 2014 (21 years) were included in the study. The data were obtained form a prospectively maintained liver surgical and pathological database. Patient demographics, clinico-pathological characteristics, operative data and post-operative outcome were collected. <h3>Results</h3> 29 patients had surgery for BCA. Median age was 62 (IQ 48–74) years and the Male:Female ratio was 28:1. The main clinical presentation was abdominal pain (74%) followed by jaundice (20%), abdominal mass (14%) and deranged LFTs (3%). On pre-operative imaging, single cyst was seen in 76% of patients. The majority of cysts were found at central location (48%). Cyst characteristics included septations (48%), wall thickening (31%), wall irregularity (38%), papillary projections (10%) and mural nodule (3%). Surgical procedures performed as follows: atypical liver resection (45%), left hemihepatectomy (34%), right hemihepatectomy (10%), excision of extra hepatic bile duct (7%) and left lateral segmentectomy (3%). Three patients had de-roofing for suspected simple liver cyst, which were confirmed on histology as biliary cystadenoma. All had re-resection with clear margins. Median length of stay was 7 (IQ 6.5 – 8.5) days. 2 patients developed bile leak, one each managed conservatively and with ERCP. There was no peri-operative mortality. None of the patients had evidence of malignancy on final histology. Median follow-up was 11 (IQ 2–44) months. One patient developed delayed biliary stricture requiring reconstruction. One died 11 years later due to development of inoperable cholangiocarcinoma. <h3>Disclosure of interest</h3> None Declared. <h3>Conclusion</h3> Biliary cystadenomas can be resected safely with significantly low morbidity. Malignant transformation and recurrence are rare. Complete surgical resection provides a cure.
THU0499 Various Inflammatory Phenotypes in V200M NLRP3 Defect Carriers
Authors: A. Kozlova, V. Bobrynina, T. Varlamova, A. Maschan, A. Shcherbina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Cryopyrin-associated periodic syndrome (CAPS) is a very rare auto-inflammatory syndrome. CAPS is caused by mutations of the NLRP3 gene that encodes crypoyrin protein that is a part of inflammasome complex. CAPS patients can present with different phenotypes of the disease – Familial cold urticaria, Muckle-Wells syndrome, and the most severe phenotype – neonatal onset multisystem inflammatory disease (NOMID). CAPS patients experience symptoms of systemic inflammation, intense fatigue and have poor quality of life. In the most severe forms, they may develop serious organ damage such as visual and hearing impairment, arthritis, neurological deterioration and renal insufficiency. However, V200M mutation has been associated with mild inflammatory phenotype and its pathogenic role is even questioned by some. We report two families of V200M mutation carriers, with variable inflammatory phenotypes. In all cases mutations of MEFV, MVK, TNFRSF1A genes were excluded. <h3>Objectives</h3> <i>Family 1.</i> Index case is a 1,5 years old female, that has been suffering from symptoms similar to Muckle-Wells syndrome: weekly episodes of fever and urticarial rash since infancy, accompanied by high laboratory inflammatory parameters (elevated ESR, CRP, hypergammaglobulinemia). Focal and diffuse changes were found on brain MRI, mild developmental delay was noted. Cerebrospinal fluid, audiogram were normal. She was started on IL1 inhibitor therapy (anakinra) with complete resolution of her symptoms. Sister, mother and grandmother of girl have the same mutation. The sister and mother have no symptoms of the disease. Yet, grandmother started having symptoms of recurrent fever, arthritis since the age of 10 years, and currently, at the age of 50 years, has a significant a hearing loss. <h3>Methods</h3> <i>Family 2.</i> The index case, 4 years old female, has been suffering from 2 years of age from monthly episodes that could be classified as PFAPA (periodic fever-pharyngitis-polyadenitis- aphtous stomatitis): 1-2 days long episodes of fever, pharyngitis, stomatitis and high laboratory activity. Brain MRI, cerebrospinal fluid, audiogram, vision were normal. Girl9s father carries the same mutation, but he has no clinical symptoms of PFAPA or CAPS <h3>Conclusions</h3> The NLRP3 V200M variant carriers show variable expressivity of the disease, the pathogenic role of this mutation and indications for therapy require further investigation. It will be interesting to screen typical PFAPA patients for V200M carrier status. <h3>Disclosure of Interest</h3> None declared
What were the received dose intensities in the three arms?
Authors: W M Hryniuk
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.7.1321 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2045873 What were the received dose intensities in the three arms? W M HryniukxW M HryniukSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.7.1321 PDF "What were the received dose intensities in the three arms?." Journal of Clinical Oncology, 9(7), pp. 1321–1322© 1991 by American Society of Clinical Oncology
Abstract 19684: Nitric Oxide Protects From Cardiac Ischemia/reperfusion Damage by Blocking Activation of Extracellular Matrix Metalloproteinase Inducer EMMPRIN Through Binding to Caveolin3
Authors: Irene Cuadrado, Ana M Martin, Marta Saura, Jose L Zamorano, Carlos Zaragoza
Journal: Circulation (2015)

Introduction: Nitric Oxide (NO) induces cardiac protection by still unknown mechanisms. We previously found that Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) is a target of NO during ischemia/reperfusion (IR). Hypothesis: EMMPRIN is glycosylated at different locations, and high glycosylated forms of EMMPRIN are required for matrix metalloproteinase downstream activation in several cell types. In hearts subject to IR NO may inhibit EMMPRIN glycosylation. Methods: A surgical model of coronary artery occlusion. Results: We found that iNOS null mice show high glycosylated (active) forms of EMMPRIN, whereas NO producing mice also show low glycosylated EMMPRIN. Likewise, NO producing mice exhibit a significant level of cardiac protection, as shown by increased left ventricle ejection fraction detected by high frequency ultrasound, and decreased area of infarction as shown by ex vivo TTC staining. To test whether low glycosylated forms of EMMPRIN may play a role in iNOS WT cardiac protection, we found that EMMPRIN binds to caveolin-3 in healthy hearts, however, I/R prompted the disruption of low glycosylated EMMPRIN from caveolin-3 in iNOS null mice in a time dependent manner whereas a significant low glycosylated portion of EMMPRIN remained bound to caveolin-3 in iNOS WT mice. To study this effect in more detail, we found that caveolin-3 binding to low glycosylated forms of EMMPRIN, prevents downstream EMMPRIN-mediated extracellular matrix degradation through matrix metalloproteinase activation. I/R damage resulted more severe in caveolin-3 null mice, where no low glycosylated EMMPRIN was detected after reperfusion. Conclusions: We show for the first time that caveolin-3 induces nitric oxide mediated cardiac protection by preventing glycosylation of EMMPRIN in mouse hearts.
A placebo-controlled trial of trihexyphenidyl in unmedicated patients with schizophrenia
Authors: D C Goff, E Amico, D Dreyfuss, D Ciraulo
Journal: American Journal of Psychiatry (1994)

Seventeen patients with schizophrenia who had been free of medication for at least 2 months entered a placebo-controlled, random-order crossover trial of 5 mg of trihexyphenidyl twice daily for 4 weeks. Ten patients completed trials of both drug and placebo. Ratings of anticholinergic symptoms and of feeling the effects of the drug, controlled for order effects, were significantly higher at week 4 of the trihexyphenidyl trial than at week 4 of the placebo trial. Measures of psychosis, negative symptoms, depression, and liking the drug did not differ between trihexyphenidyl and placebo trials.
Massachusetts Medical Society
Authors: Stephen Evans, Fredric D. Frigoletto, John Figgis Jewett
Journal: New England Journal of Medicine (1983)

Fulminating eclampsia developed in a 34-year-old gravida III para I at the gestational age of 34 weeks.The previous term pregnancy had been uncomplicated, ending 15 months earlier in a normal vaginal delivery. The history was unremarkable, specifically excluding hypertension, vascular disease, coagulopathy, or previous seizure disorder.At 15 and 19 weeks the patient's blood pressure had been recorded at 130/88 and 120/88 mm Hg, respectively, without albuminuria and with a weight gain of only 2.3 kg. The patient moved to another city and did not see her new obstetrician until the 28th week, when her blood pressure was found . . .
Inhibition of Ehrlich Ascites Tumor Growth by Nucleoprotein. I. &lt;italic&gt;In Vivo&lt;/italic&gt; Characterization and Presumptive Chemical Identification&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: L. Jack Bradshaw, Lyle H. Rosser, Jr.
Journal: JNCI Journal of the National Cancer Institute (1969)

A badly degraded preparation of herring-sperm deoxyribonucleic acid (DNA) prevented the development of Ehrlich ascites tumor in mice, though, in large doses, this substance appeared to be nontoxic. The protective ability of the DNA preparation was destroyed completely by proteolytic enzymes, but only partially by deoxyribonuclease and not at all by ribonuclease. Biochemical fractionation revealed that the chloroform-extracted protein was active in this regard, but the relatively protein-free DNA part was not. There is evidence that the protective substance is probably the normal protamine of herring sperm (clupeine), with a small amount of residual DNA attached.
Manic syndrome early and late in the course of HIV
Authors: C G Lyketsos, A L Hanson, M Fishman, A Rosenblatt, P R McHugh, G J Treisman
Journal: American Journal of Psychiatry (1993)

In a chart review at a hospital's infectious disease AIDS clinic, manic syndromes affected 8% of patients who had AIDS. Of the 14 patients with manic episodes, those without a family or personal history of mood disorder presented later in the course of HIV infection and had a higher prevalence of comorbid dementia.
Rheumatoid Arthritis
Authors: Janet M. Torpy
Journal: JAMA (2011)

Rheumatoid ArthritisR heumatoid arthritis (RA) is an autoimmune disease that can affect joints, the heart, the skin, and other body organs.Autoimmune diseases such as RA and systemic lupus erythematosus are caused by factors that prompt the body to attack itself.These factors, which normally help fight off infection, target the synovial membrane (joint lining) in RA.These linings are elastic and help the joint maintain its shape; damage to the linings allows the bones to change their position, leading the joint to become deformed.Inflammation can also affect other body parts.In some persons with RA, the autoimmune process affects the heart and its lining (the pericardium) or the lining of the lungs (the pleura).If fluid builds up within the pericardium or pleura, this can be life-threatening and require emergency drainage.Women are more likely to have RA than men.About 1% of the world' s population may have RA.The cause of RA is unclear, but it probably has a genetic (inherited) influence in addition to outside (environmental) factors.
Low CSF 5-hydroxyindoleacetic acid in schizophrenic patients with enlarged cerebral ventricles
Authors: S G Potkin, D R Weinberger, M Linnoila, R J Wyatt
Journal: American Journal of Psychiatry (1983)

The authors assayed CSF 5-hydroxyindoleacetic acid (5-HIAA) concentrations in 24 chronic schizophrenic patients, 9 of whom had enlarged cerebral ventricles according to computerized tomography scans, and in 15 control subjects with neurological disorders. Although there were no overall differences between the schizophrenic patients and the control subjects, schizophrenic patients with enlarged ventricles had significantly lower 5-HIAA concentrations. Also, ventricular size correlated inversely with 5-HIAA concentrations. The findings are consistent with other evidence that cerebral ventricular size is biologically meaningful in schizophrenic patients.
Abstract 14622: Cardiac Resynchronization Therapy in Patients With RBBB in the Ontario ICD Registry; Assessment of Contemporary Practice and Outcomes.
Authors: David H Birnie, Douglas S Lee, Eugene Crystal, Andrew D Krahn, Yaariv Khaykin, Christopher S Simpson, Jeffrey S Healey, Douglas Cameron, Amir Janmohamed, Peter C Austin, Pablo B Nery, Jack V Tu
Journal: Circulation (2010)

Background: Cardiac Resynchronization Therapy (CRT) can improve outcomes in heart failure patients with prolonged QRS duration. Accumulating data suggests that patients with LBBB are most likely to...
A phase II study of live-attenuated <i>listeria</i> monocytogenes immunotherapy (ADXS11-001) in the treatment of persistent or recurrent cancer of the cervix (GOG-0265).
Authors: Warner King Huh
Journal: Journal of Clinical Oncology (2012)

TPS5115 Background: This is a GOG/NCI sponsored phase II study (NCT01266460, GOG 0265) of ADXS11-001 in patients with persistent or recurrent cancer of the cervix. ADXS11-001 is a live attenuated Listeria monocytogenes (Lm) immunotherapy bioengineered to secret a HPV E7 fusion protein targeting HPV-E7 transformed cells. A previous phase I dose escalation study determined the safety of ADXS11-001 in patients with late stage cervical cancer (Maciag PA. Vaccine. 2009 Jun 18;27(30):3975-83). The primary objectives of this study are: to evaluate the tolerability and safety of ADXS11-001; and to assess the activity of ADXS11-001 in patients with persistent or recurrent cancer of the cervix. Secondary objectives are progression-free survival, overall survival and objective tumor response. Methods: Patient eligibility criteria: Females age ≥ 18 years with persistent or recurrent squamous or non-squamous cell carcinoma, adenosquamous carcinoma, or adenocarcinoma of the cervix with documented disease progression (disease not amenable to curative therapy). Patients must have measurable disease as defined by RECIST 1.1; at least one “target lesion” as defined by RECIST 1.1; have had one prior systemic chemotherapeutic regimen for management of their disease; have adequate organ function and must be free of active infection and not on antibiotics. This protocol is a Simon 2-stage design with a planned sample size of up to 67 patients. Patients will receive ADXS11-001 at a dose of 1x10 9 CFU on Day 1 and repeat every 28 days for 3 total doses in the absence of disease progression or unacceptable toxicity, with each dose followed at 72 hours by a 7 day course of ampicillin, 500 mg QID. Tumor tissue and serum samples may be collected periodically for translational research. After completion of study treatment, patients are followed every 3 months for 2 years and then every 6 months for 3 years. This phase II study just began enrolling and as of January 27, 2012, 2 patients have been enrolled.
Effect of recombinant canine granulocyte-macrophage colony-stimulating factor on hematopoietic recovery after otherwise lethal total body irradiation
Authors: RA Nash, FG Schuening, K Seidel, FR Appelbaum, T Boone, HJ Deeg, TC Graham, R Hackman, M Sullivan-Pepe, R Storb
Journal: Blood (1994)
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1978)

COMMITTEE ON MATERNAL WELFARETwo Dissecting Coronary-Artery Aneurysms Post PartumCase 1. Between the ages of 21 and 40 years an apparently normal woman was delivered at term of four infants of average birth weight. The pregnancies, parturitions and puerperia were uneventful. During the final pregnancy, excellent prenatal care had begun at 12 weeks, physical and laboratory data being within normal limits except for a hemoglobin of 76 per cent (Sahli) and a borderline blood pressure of 150/80 mm Hg throughout. Total weight gain had been 13 kg. A carefully scrutinized past history was unremarkable. At term, an easy labor . . .
Correlation between serum and salivary cortisol levels in depressed and nondepressed children and adolescents
Authors: P M Burke, R J Reichler, E Smith, K Dugaw, E McCauley, J Mitchell
Journal: American Journal of Psychiatry (1985)

Serum and saliva cortisol levels were determined in 34 depressed and nondepressed children and adolescents. The serum and salivary measures were highly correlated. The measurement of salivary cortisol may be a useful noninvasive technique in the study of cortisol secretion patterns in young subjects.