tbuckley/cabot-search huggingface dataset:
Management of patients with diabetes and CKD: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference
Authors: Vlado Perkovic, Rajiv Agarwal, Paola Fioretto, Brenda R. Hemmelgarn, Adeera Levin, Merlin C. Thomas, Christoph Wanner, Bertram L. Kasiske, David C. Wheeler, Per-Henrik Groop, George L. Bakris, Mark E. Cooper, Dong-Wan Chae, Michael H. Davidson, Ian H. de Boer, Dick de Zeeuw, Alessia Fornoni, Luigi Gnudi, Charles A. Herzog, Adriana M. Hung, Tazeen Hasan Jafar, Meg Jardine, Vivekanand Jha, Linong Ji, Steven E. Kahn, Robyn G. Langham, Edgar V. Lerma, Ronald C.W. Ma, Hirofumi Makino, Michel Marre, Michael Mauer, Kaj Metsärinne, Robert G. Nelson, Roberto Pecoits-Filho, Carol A. Pollock, Mohan Rajapurkar, Peter Rossing, Ivan Rychlík, Kumar Sharma, Robert C. Stanton, Vladimír Tesař, Ilkka Tikkanen, Charlie R.V. Tomson, Robert D. Toto, Yusuke Tsukamoto, Katherine R. Tuttle, Takashi Wada, Winfred W. Williams, Hong Zhang, Sophia Zoungas
Journal: Kidney International (2016)

The prevalence of diabetes around the world has reached epidemic proportions and is projected to increase to 642 million people by 2040. Diabetes is already the leading cause of end-stage kidney disease (ESKD) in most developed countries, and the growth in the number of people with ESKD around the world parallels the increase in diabetes. The presence of kidney disease is associated with a markedly elevated risk of cardiovascular disease and death in people with diabetes. Several new therapies and novel investigational agents targeting chronic kidney disease patients with diabetes are now under development. This conference was convened to assess our current state of knowledge regarding optimal glycemic control, current antidiabetic agents and their safety, and new therapies being developed to improve kidney function and cardiovascular outcomes for this vulnerable population.
Differential Effects of Lovastatin and Allopurinol Therapy in a Murine Model of Sickle Cell Disease.
Authors: Kirkwood A. Pritchard, Terri L. Besch, Jingli Wang, Hao Xu, Deron W. Jones, Thomas D. Foster, Sandra L. Holzhauer, Keith T. Oldham, Nancy J. Wandersee, Cheryl A. Hillery
Journal: Blood (2005)
Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor–mediated inflammatory responses
Authors: Andreas Westphal, Weijia Cheng, Jinbo Yu, Guntram Grassl, Martina Krautkrämer, Otto Holst, Niko Föger, Kyeong-Hee Lee
Journal: The Journal of Experimental Medicine (2016)

Subcellular compartmentalization of receptor signaling is an emerging principle in innate immunity. However, the functional integration of receptor signaling pathways into membrane trafficking routes and its physiological relevance for immune responses is still largely unclear. In this study, using Lyst-mutant beige mice, we show that lysosomal trafficking regulator Lyst links endolysosomal organization to the selective control of toll-like receptor 3 (TLR3)- and TLR4-mediated proinflammatory responses. Consequently, Lyst-mutant mice showed increased susceptibility to bacterial infection and were largely resistant to endotoxin-induced septic shock. Mechanistic analysis revealed that Lyst specifically controls TLR3- and TLR4-induced endosomal TRIF (TIR domain-containing adapter-inducing interferon β) signaling pathways. Loss of functional Lyst leads to dysregulated phagosomal maturation, resulting in a failure to form an activation-induced Rab7+ endosomal/phagosomal compartment. This specific Rab7+ compartment was further demonstrated to serve as a major site for active TRIF signaling events, thus linking phagosomal maturation to specific TLR signaling pathways. The immunoregulatory role of Lyst on TLR signaling pathways was confirmed in human cells by CRISPR/Cas9-mediated gene inactivation. As mutations in LYST cause human Chédiak-Higashi syndrome, a severe immunodeficiency, our findings also contribute to a better understanding of human disease mechanisms.
Bortezomib + MEC (Mitoxantrone, Etoposide, Cytarabine) for Relapsed/ Refractory Acute Myeloid Leukemia: Final Results of an Expanded Phase 1 Trial
Authors: Anjali S. Advani, Paul Elson, Matt E. Kalaycio, Sudipto Mukherjee, Aaron T. Gerds, Betty K. Hamilton, Sean Hobson, Arian Smith, Mary Lynn Rush, Samjhana Bogati, Monique Biggins, Eric D. Hsi, Hien K. Duong, Edward A. Copelan, Frederic J. Reu, Yogen Saunthararajah, Aziz Nazha, Hideki Makishima, Bartlomiej Przychodzen, Brittney Dienes, Jaroslaw P. Maciejewski, Jennifer S Carew, Hetty E. Carraway, Mikkael A. Sekeres
Journal: Blood (2014)
Association Analysis of Polymorphisms and Epistasis of Genes of IL-6, IL-10 and TNF-a in Patients with MM Submitted to ASCT
Authors: Fernanda M B Trigo, Marcelo Luizon Rizzatti, Hélio Dutra, Maria Helena S Scaffo, Aguinaldo Luizon Simões, Angelo Maiolino, M. Nucci, Belinda Pinto Simoes
Journal: Blood (2012)
Progression characteristics of the European Friedreich’s Ataxia Consortium for Translational Studies (EFACTS): a 2 year cohort study
Authors: Kathrin Reetz, Imis Dogan, Ralf-Dieter Hilgers, Paola Giunti, Caterina Mariotti, Alexandra Durr, Sylvia Boesch, Thomas Klopstock, Francisco Javier Rodriguez de Rivera, Ludger Schöls, Thomas Klockgether, Katrin Bürk, Myriam Rai, Massimo Pandolfo, Jörg B Schulz, Wolfgang Nachbauer, Andreas Eigentler, Chantal Depondt, Sandra Benaich, Perrine Charles, Claire Ewenczyk, Marie-Lorraine Monin, Manuel Dafotakis, Kathrin Fedosov, Claire Didszun, Ummehan Ermis, Ilaria A Giordano, Dagmar Timmann, Ivan Karin, Christiane Neuhofer, Claudia Stendel, Jennifer Müller vom Hagen, Julia Wolf, Marta Panzeri, Lorenzo Nanetti, Anna Castaldo, Javier Arpa, Irene Sanz-Gallego, Michael H Parkinson, Mary G Sweeney
Journal: The Lancet Neurology (2016)
PTH-006 Computer-Aided Lesion Measurement in Capsule Endoscopy Images
Authors: A Koulaouzidis, D Chatzis, P Chrysanthopoulos, DK Iakovidis
Journal: Gut (2016)

<h3>Introduction</h3> A novel image segmentation algorithm is applied &amp; assessed for lesion size measurements in capsule endoscopy (CE). It is based solely on colour features of CE lesions. <h3>Methods</h3> The lesion images are available online from <b>KID</b> database (Dataset 1).<sup>1</sup> Size reference standards were made by manual annotation. The proposed algorithm uses the CIE-Lab colour representation instead of the standard RGB used in CE.<sup>1</sup> The components of this space represent lightness (L), the quantity of red (a &gt; 0) or the quantity of green (-a &gt;0), the quantity of yellow (b &gt; 0) or the quantity of blue (-b &gt;0) of a pixel. Initially, the user specifies a point on the lesion of interest (with a single click). Simple Linear Iterative Clustering (SLIC) is applied to group the pixels of similar colour into contiguous regions, called superpixels.<sup>2</sup> Subsequently the superpixels are clustered using the k-means approach into three clusters using information from component a. Thereafter, each superpixel neighbouring to the superpixel that contains the user-specified point is represented by a colour vector (a, b). The proposed algorithm estimates a) its Euclidean distance d1 from the respective vector of the selected superpixel, b) its Euclidean distance d2 from the mean of the respective vectors obtained from all superpixels that do not belong to the cluster of the selected superpixel. Then, the neigerpixel is considered to belong to the abnormal region of interest if d1 <h3>Results</h3> Seven types of GI lesions were used for evaluation. The measurement accuracy was assessed by comparing the area of the lesion (as identified by the method) with the reference standard area of each lesion. Average accuracies obtained for the measurement of angioectasias, aphthae, chylous cysts, lymphangiectasias, polypoid lesions, stenoses, and ulcers are 98.6%, 92.8%, 94.3%, 99.1%, 80.0%, 82.9%, and 94.8%, respectively. Comparatively, using the well-known colour space proposed by Ohta (I1I2I3) for image segmentation instead of CIE-Lab<sup>2</sup> the results are lower; 97.1%, 92.1%, 92.6%, 97.8%, 75.2%, 78.8%, and 91%, respectively. <h3>Conclusion</h3> A novel algorithm was proposed &amp; evaluated for accurate computer-aided size measurement of lesions in CE. The overall accuracy on a public dataset was ~92%. This algorithm can be incorporated as a novel measurement tool in contemporary CE reading software. <h3>References</h3> 1 Iakovidis DK, Koulaouzidis A. Software for enhanced video capsule endoscopy: challenges for essential progress. <i>Nat Rev Gastroenterol Hepatol</i>. 2015;<b>12</b>:172–8. 2 Achanta R, <i>et al</i>. Slic superpixels compared to state-of-the-art superpixel methods. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. 2012;<b>34</b>:2274–8. <h3>Disclosure of Interest</h3> None Declared
Bi-Phenotypic Leukemic Cells as Transient Intermediates Between Leukemic Stem Cells with Lymphoid Characteristics and the Leukemic Myeloid Bulk: Insights from a Murine Model of CALM/AF10 Positive Acute Myeloid Leukemia
Authors: Aniruddha Deshpande, Hendrik Reuter, Medhanie Mulaw, Monica Cusan, Wolfgang Hiddemann, Stefan Bohlander, Michaela Feuring-Buske, Christian Buske
Journal: Blood (2008)
Cardiovascular risk in patients with psoriasis, psoriatic arthritis, and rheumatoid arthritis: a prospective study of data from the Secure Anonymised Information Linkage databank
Authors: Roxanne Cooksey, Sinead Brophy, Jonathan Kennedy, Fabiola Fernandez Guiterrez, Tim Pickles, Ruth Davies, Vincent Piguet, Ernest Choy
Journal: The Lancet (2016)
Myelodysplastic Syndrome Patients Show Mutation-Specific DNA Methylation Patterns
Authors: Constance Regina Baer, Niroshan Nadarajah, Yasunobu Nagata, Tamara Alpermann, Genta Nagae, Yusuke Okuno, Yuichi Shiraishi, Satoru Miyano, Claudia Haferlach, Wolfgang Kern, Hiroyuki Aburatani, Seishi Ogawa, Torsten Haferlach
Journal: Blood (2015)
Enhanced Natural Killer (NK) and NK T Cell Activation, Expansion and Cytokine Protein Production Following Ex-Vivo Engineering (EvE) of Cryopreserved Umbilical Cord Blood (UCB): Potential Role of CB NK and NKT Cells in Adoptive Cellular Immunotherapy (ACI).
Authors: Janet Ayello, Prakash Satwani, Carmella van de Ven, Laxmi Baxi, Ronald Wapner, Etan Sugarman, Mitchell S. Cairo
Journal: Blood (2007)
Reply from Authors re: Steven C. Campbell, Wen Dong, Joe Zabell, Diego Aguilar Palacios. End-stage Renal Disease After Renal Surgery: Partial Nephrectomy Is Protective, but to What Degree and Consequence? Eur Urol 2016;70:562–3
Authors: Umberto Capitanio, Alessandro Larcher, Paolo Dell’Oglio, Francesco Montorsi, Roberto Bertini
Journal: European Urology (2016)
For Standard and High-Risk Patients with Hodgkin Lymphoma Six Cycles of Tailored BEACOPP, Based On Interim Scintigraphy, Are Effective and Female Fertility Is Preserved.
Authors: Eldad Dann, Rachel Bar-Shalom, Ada Tamir, Menachem Ben-Shachar, Irit Avivi, Tsila Zuckerman, Nuhad Haddad, Hanna Rosenbaum, Riva Fineman, Odelia Goor, Diana Libster, Zeev Blumenfeld, Jacob M. Rowe, Ron Epelbaum
Journal: Blood (2009)
Azacitidine in Combination with the Selective FLT3 Kinase Inhibitor Crenolanib Effectively Disrupts Stromal Protection of CD34+ Leukemia-Initiating Cells (LIC) in FLT3-ITD+ Acute Myeloid Leukemia (AML)
Authors: Anne-Kathrin Garz, Stefan Habringer, Saskia Wolf, Binje Vick, Marie-Theresa Weickert, Irmela Jeremias, Karsten Spiekermann, Christian Peschel, Robert A.J. Oostendorp, Ulrich Keller, Katharina S. Götze
Journal: Blood (2015)
Drug-induced co-assembly of albumin/catalase as smart nano-theranostics for deep intra-tumoral penetration, hypoxia relieve, and synergistic combination therapy
Authors: Qian Chen, Jiawen Chen, Chao Liang, Liangzhu Feng, Ziliang Dong, Xuejiao Song, Guosheng Song, Zhuang Liu
Journal: Journal of Controlled Release (2016)
FRI0511 The Effect of Attack Frequency on Quality of Life (QOL) and Mental Health in Patients with Familial Mediterranean Fever (FMF)
Authors: M.E. Enecik, A. Omma, Y. Karaaslan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> FMF is an inherited autoinflammatory disease characterized by recurrent episodes of fever, acute serosal inflammation and pain. The QoL and mental health of FMF patients may be affected due to life-long disease, attack frequency, resistance of the disease, and severe complications such as amyloidosis. <h3>Objectives</h3> In this study, we investigated the effect of attack frequency on QoL and mental health (MH) in FMF patients. <h3>Methods</h3> A total of 149 patients (79 F, 70 M) diagnosed with FMF in Ankara Numune Education and Research Hospital Rheumatology Clinic, and 100 healthy controls (HC) (54 F, 46 M) were included in the study. Patients diagnosed with FMF according to Tel-Hashomer criteria. Mean±SD age of FMF patients is 36±10 year, and mean±SD age of HC is 35±8 year, NS. Mean±SD at onset of FMF patients is 17±4 year, and mean±SD age of disease duration is 107±71 months. FMF patients were classified as the ones that had &gt;2, 1–2, and no attacks in the previous 3 months. The QoL was determined with SF-36, and MH was analyzed with Hospital Anxiety and Depression Scale (HADS). Student t test was used to compare FMF and HC groups for HADS-Anxiety (HADS-A) and HADS-Depression (HADS-D) scores, and physical component summary scores (PCSS), mental component summary scores (MCSS), and subscale scores of SF-36. One Way Anova was used to analyze FMF patients for HADS-A and HADS-D, and PCSS and MCSS of SF-36 in relation with attack frequency. The associations of age, gender, SF-36 and HADS scores in both groups, and comparisons of SF-36 and HADS scores in relation with age at diagnosis and duration of disease in FMF patients were analyzed with Pearson9s correlation. p&lt;0.05 was regarded as significant. <h3>Results</h3> The summary scores of SF-36, and HADS-A and HADS-D of FMF patients and HC are presented in Tables 1. SF-36 summary scores, and HADS scores of FMF patients in relation with attack frequency, and SF-36 subscale scores of FMF patients and HC are presented in Table 2 and Figure 1. There were no significant correlations among age and gender, and QoL and mental health scores in either group. PCSS and MCSS of SF-36 were significantly lower, and HADS-A and HADS-D scores were significantly higher in FMF patients compared to HC (p&lt;0.001). In addition, attack frequency showed negative correlations with PCSS and MCSS, and positive correlations with HADS-A and HADS-D in FMF patients (p&lt;0.001). PCSS and MCSS showed negative correlations with HADS-A and HADS-D in FMF patients (p&lt;0.001). Age at diagnosis and duration of disease were not correlated with QoL or MH scores. <h3>Conclusions</h3> In this study, we found lower QoL scores, and higher anxiety and depression scores in FMF patients compared to HC. Attack frequency determined this effect independent of age and gender. <h3>Disclosure of Interest</h3> None declared
Effective Hematopoietic Stem Cell Transplantation with Reduced Intensity Conditioning for Patients with Chronic Granulomatous Disease.
Authors: Yoko Mizoguchi, Mizuka Miki, Teruyuki Kajiume, Hiroshi Kawaguchi, Kazuhiro Nakamura, Takashi Sato, Masao Kobayashi
Journal: Blood (2009)
Phase 2 Study of Lenalidomide in Combination with Low-Dose Dexamethasone in Japanese Transplantation-Ineligible Newly-Diagnosed Multiple Myeloma Patients
Authors: Takaaki Chou, Atsushi Shinagawa, Toshiki Uchida, Masafumi Taniwaki, Hirokazu Hirata, Kenichi Ishizawa, Kosei Matsue, Yoshiaki Ogawa, Takayuki Shimizu, Maki Otsuka, Morio Matsumoto, Shinsuke Iida, Yasuhito Terui, Itaru Matsumura, Takashi Ikeda, Naoki Takezako, Yumi Ogaki, Shuichi Midorikawa, Vanessa Houck, Annette Ervin-Haynes, Kenshi Suzuki
Journal: Blood (2014)
OP0181 Prediction of Flare after Stopping TNF-Inhibitor by Baseline Ultrasonography and Patient Characteristics in Rheumatoid Arthritis Patients with Low Disease Activity: 12-Month Results
Authors: F.B.G. Lamers-Karnebeek, J. Luime, P. van Riel, J. Jacobs, T. Jansen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> A significant number of rheumatoid arthritis (RA) patients can reach low disease activity (LDA) by using TNF-inhibitors (TNF-i), but this therapy can cause serious side-effects and is expensive. Therefore it could be expedient to stop in case of LDA, unless a relapse can be predicted. Ultrasonography of joints seems to be a predictor in this respect in smaller studies. The Dutch POET (Potential Optimalisation of Expediency of TNF-i (TNF-inhibitor)) study, is a multicenter randomized prospective cohort study investigating if in patients with RA with LDA on TNF-i and conventional DMARD, the TNF-i can be stopped. Patients were randomized to continue or stop TNF-i. Part of this study is the POET-ultrasonography (US) study. <h3>Objectives</h3> To investigate whether US, at the time of stopping TNF-i in RA patients with LDA, is an additive predictor for flare besides clinical data. <h3>Methods</h3> Data were analysed of 251 patients who stopped TNF-i in the POET study. Participating patients had RA according to ACR 1987 criteria, &gt;6 months a DAS28 &lt;3.2 (LDA) and treatment with TNF-i &gt;1 year next to a conventional DMARD, with no dose change 6 months prior to randomisation. Nineteen trained ultrasonographers performed at baseline of the study US (with different US machines) of 20 joints: MCP 1–5 dorsal and volar, wrist and MTP 2–5 dorsal aspect, all bilaterally. The joints were graded on grayscale (GS; 0–3) and power Doppler (PD; 0–3). US signs of arthritis were defined as GS&gt;1 and/or PD&gt;0. Trial visits were performed every 3 months during 12 months and intercurrently when flare was suspected. Flare was defined as DAS28 &gt;3.2 and at least &gt;0.6 increase compared to the baseline DAS28. Univariate and multivariate Cox-regression was performed guided by clinical factors described in the literature and US. <h3>Results</h3> The Kaplan Meier curve for patients with US signs of arthritis in one or more joints shows greater/higher risk of flare and shorter relapse-free period compared to the curve for patients without US signs of arthritis, p= (figure). At multivariate analysis (table), correcting for potentially clinical predictors, US detected arthritis stayed a statistically significant predictor of flare; HR 1.69; 95% CI 1.11 to 2.53. The predictive value of US seems not that strong that it can be used in individual patients. <h3>Conclusions</h3> The presence of US arthritis is associated with an earlier flare and a higher flare rate compared to those with negative US taking into account demographic and clinical patient characteristics. <h3>Disclosure of Interest</h3> F. Lamers-Karnebeek Grant/research support from: Abbvie, J. Luime: None declared, P. van Riel: None declared, J. Jacobs: None declared, T. Jansen: None declared
Interferons Downregulate the Expression of WT1 in Myeloid Leukemia through the JAK/STAT Pathway and This Potentiates Chemotherapy Induced Apoptosis.
Authors: Hima Bansal, Sanjay Bansal, Prakash Varadarajan, Elizabeth Repasky, Asher Chanan-Khan, Kelvin P. Lee, Swaminathan Padmanabhan
Journal: Blood (2007)
Postoperative Pulmonary Complications, Early Mortality, and Hospital Stay Following Noncardiothoracic Surgery
Authors: Ana Fernandez-Bustamante, Gyorgy Frendl, Juraj Sprung, Daryl J. Kor, Bala Subramaniam, Ricardo Martinez Ruiz, Jae-Woo Lee, William G. Henderson, Angela Moss, Nitin Mehdiratta, Megan M. Colwell, Karsten Bartels, Kerstin Kolodzie, Jadelis Giquel, Marcos Francisco Vidal Melo
Journal: JAMA Surgery (2016)

Postoperative pulmonary complications (PPCs), a leading cause of poor surgical outcomes, are heterogeneous in their pathophysiology, severity, and reporting accuracy.To prospectively study clinical and radiological PPCs and respiratory insufficiency therapies in a high-risk surgical population.We performed a multicenter prospective observational study in 7 US academic institutions. American Society of Anesthesiologists physical status 3 patients who presented for noncardiothoracic surgery requiring 2 hours or more of general anesthesia with mechanical ventilation from May to November 2014 were included in the study. We hypothesized that PPCs, even mild, would be associated with early postoperative mortality and use of hospital resources. We analyzed their association with modifiable perioperative variables.Noncardiothoracic surgery.Predefined PPCs occurring within the first 7 postoperative days were prospectively identified. We used bivariable and logistic regression analyses to study the association of PPCs with ventilatory and other perioperative variables.This study included 1202 patients who underwent predominantly abdominal, orthopedic, and neurological procedures. The mean (SD) age of patients was 62.1 (13.8) years, and 636 (52.9%) were men. At least 1 PPC occurred in 401 patients (33.4%), mainly the need for prolonged oxygen therapy by nasal cannula (n = 235; 19.6%) and atelectasis (n = 206; 17.1%). Patients with 1 or more PPCs, even mild, had significantly increased early postoperative mortality, intensive care unit (ICU) admission, and ICU/hospital length of stay. Significant PPC risk factors included nonmodifiable (emergency [yes vs no]: odds ratio [OR], 4.47, 95% CI, 1.59-12.56; surgical site [abdominal/pelvic vs nonabdominal/pelvic]: OR, 2.54, 95% CI, 1.67-3.89; and age [in years]: OR, 1.03, 95% CI, 1.02-1.05) and potentially modifiable (colloid administration [yes vs no]: OR, 1.75, 95% CI, 1.03-2.97; preoperative oxygenation: OR, 0.86, 95% CI, 0.80-0.93; blood loss [in milliliters]: OR, 1.17, 95% CI, 1.05-1.30; anesthesia duration [in minutes]: OR, 1.14, 95% CI, 1.05-1.24; and tidal volume [in milliliters per kilogram of predicted body weight]: OR, 1.12, 95% CI, 1.01-1.24) factors.Postoperative pulmonary complications are common in patients with American Society of Anesthesiologists physical status 3, despite current protective ventilation practices. Even mild PPCs are associated with increased early postoperative mortality, ICU admission, and length of stay (ICU and hospital). Mild frequent PPCs (eg, atelectasis and prolonged oxygen therapy need) deserve increased attention and intervention for improving perioperative outcomes.
Phase I Trial of Bortezomib in Combination with Rituximab-HyperCVAD/Methotrexate and Cytarabine for Untreated Mantle Cell Lymphoma
Authors: Jorge Romaguera, Luis Fayad, Peter McLaughlin, Barbara Pro, Maria Alma Rodriguez, Michael Wang, Pamela Weaver, Kimberly Hartig, Larry Kwak, Tatyana Feldman, Judy Smith, Peggy Ford, Stuart Goldberg, Andrew Pecora, Andre Goy
Journal: Blood (2008)