tbuckley/cabot-search huggingface dataset:
Direct Synthesis of Water‐Soluble Aptamer‐Ag<sub>2</sub>S Quantum Dots at Ambient Temperature for Specific Imaging and Photothermal Therapy of Cancer
Authors: Jingwen Gao, Chuanli Wu, Dan Deng, Ping Wu, Chenxin Cai
Journal: Advanced Healthcare Materials (2016)

Water‐soluble Ag 2 S near‐infrared (NIR) fluorescent quantum dots (QDs) are directly synthesized at ambient temperature for specific cancer imaging and photothermal therapy (PTT) using a designed aptamer (Apt43) as template, which consists of the following two fragments: an aptamer S2.2 sequence for specifically recognizing the cancer cells and an 18‐cytosine (18‐C) extending spacer for growing Ag 2 S QDs. The synthesized Ag 2 S QDs (Apt43‐Ag 2 S QDs), which exhibit strong absorption and fluorescence emission in the NIR region and high photothermal conversion capabilities, can specifically recognize MCF‐7 cells (human breast cancer cells) and are usable as a highly intensified imaging agent for cancer diagnosis. Moreover, they can be applied as photothermal agents for the in vitro killing of MCF‐7 cells and the in vivo ablation of tumors, which were constructed on the bodies of nude mice. MCF‐7 cells almost quantitatively die after they are incubated with the QDs (at 100 μg mL –1 ) for 2 h and irradiated under an 808 nm laser at a power density of 1.0 W cm –2 for 10 min. The tumors on the nude mice can also be effectively ablated without regrowth during the period of observation (at least 20 d) after PTT.
Delineation of Unexpected Muscle Trauma
Authors: CLAYTON J. FRATER, I. PROVAN C. MURRAY
Journal: Clinical Nuclear Medicine (2001)

From Nuclear Diagnostics Randwick* and the School of Clinical Sciences, Charles Sturt University†, New South Wales, Australia Received for publication April 24, 2000. Accepted July 31, 2000. Reprint requests: Clayton Frater, Nuclear Diagnostics Randwick, Suite 24, Level 7, Prince of Wales Private Hospital, Randwick, New South Wales 2031, Australia.
Third Generation CD19-CAR T Cells for Relapsed and Refractory Lymphoma and Leukemia Report from the Swedish Phase I/IIa Trial
Authors: Gunilla Enblad, Hannah Karlsson, Kristina Wikstrom, Magnus Essand, Barbara Savoldo, Malcolm K. Brenner, Gianpietro Dotti, Helene Hallbook, Martin Hoglund, Hans Hagberg, Angelica Loskog
Journal: Blood (2015)
Rapid increase in lymphogranuloma venereum in men who have sex with men, United Kingdom, 2003 to September 2015
Authors: Tristan Childs, Ian Simms, Sarah Alexander, Kirstine Eastick, Gwenda Hughes, Nigel Field
Journal: Eurosurveillance (2015)

United Kingdom (UK) national data show a sharp increase in diagnoses of lymphogranuloma venereum (LGV) since 2012. Most cases are in men who have sex with men (MSM) living in London, with high rates of co-infection with HIV and other sexually transmitted infections. In light of these data, and the recent finding that one quarter of LGV infections may be asymptomatic, clinicians should be vigilant in testing for LGV, including in asymptomatic HIV-positive MSM.
Critical determinants in the emergence of broadly neutralizing CD4-binding site antibodies from an HIV-1-infected Chinese donor
Authors: L Kong, B Ju, L Ren, Y Chen, J Liu, L He, K Hong, B Su, Z Wang, G Ozorowski, X Ji, Y Hua, M.C Deller, Y Hao, Y Feng, F Garces, R Wilson, K Dai, S O'Dell, K McKee, J Mascola, A.B Ward, R.T Wyatt, Y Li, I.A Wilson, J Zhu, Y. Shao
Journal: Immunity (2016)
Hematopoiesis in the Spleen of Tumor-Bearing Hamsters&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Margaret A. Kelsall, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Hematopoiesis in the Spleen of Tumor-Bearing Hamsters Get access Margaret A. Kelsall, Ph.D. Margaret A. Kelsall, Ph.D. Department of Biology, University of Colorado, Boulder, Colo. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 625–635, https://doi.org/10.1093/jnci/10.3.625 Published: 01 December 1949 Article history Received: 16 August 1949 Published: 01 December 1949
Diagnosis of Nonalcoholic Fatty Liver Disease
Authors: Bing-yuan Wang
Journal: JAMA (2003)

有关非酒精性脂肪性肝病(NAFLD)的诊断,不同的国家或地区某些指标有一定的差别,国内目前普遍采用哑太地区NAFLD诊疗指南[1]和2006年中华医学会肝病学分会脂肪肝和酒精性肝病学组制定的NAFLD诊疗指南(以下简称中国指南)[2].这些指南对规范NAFLD的研究具有重要的指导意义,但有些内容还需要进一步明确或商榷.现结合近年的国内外研究进展和临床体会,就NAFLD临床诊断的相关问题作一简述。
Variation in Quantitative Expression of Forssman Antigen on Virus-Transformed Hamster Cells 2
Authors: Geraldine D. Shantz, Robert N. Lausch
Journal: JNCI Journal of the National Cancer Institute (1974)

The expression of Forssman antigen on normal and transformed hamster cells was investigated by a complement-dependent microcytoxicity test. The cell lines varied considerably with respect to the dilution of rabbit anti-sheep erythrocyte serum required to promote lysis. Quantitative absorption studies indicated that the amount of antiserum needed was inversely proportional to the density of Forssman antigen on the cell surface. From quantitative absorption determinations and cell size, the density of Forssman antigen on the cell surface of PARA-7C1V, transformed by PARA-adenovirus 7, DMBA3L, transformed by 9,10-dimethylbenz[a]anthracene (DMBA), 333-8-9 T#5, transformed by herpes simplex virus type 2, and untransformed hamster embryo fibroblasts (HEF) was 4.7-, 584-, 741-, and 2345-fold greater than that on Ad-7 cells, transformed by adenovirus 7. HEF preparations tested under confluent or nonconfluent conditions required significantly less antiserum tor sensitization than did lines of HEF transformed by herpes simplex virus or PARA-adenovirus 7. The results indicate that virus transformation of these cells is consistently accompanied by a reduction in Forssman antigen expression.
An outbreak of diarrhoeic shellfish poisoning in Antwerp, Belgium
Authors: K De Schrijver, I Maes, L De Man, J Michelet
Journal: Eurosurveillance (2002)

In Antwerp, Belgium, 403 cases of diarrhoeic shellfish poisoning were reported after consumption of blue mussels. Symptoms included diarrhoea, vomiting, abdominal pain, and nausea. The analysis of faecal specimens from patients allowed diagnosis exclusions for bacteria and viruses. Mouse-assays revealed the presence of biotoxins specific of dinoflagellates, which were identified and quantified by LC-MS. The mussels were imported from Denmark, and were part of a batch presenting high concentrations of okadaic acid above the regulatory limits.
A clustering approach to identify severe bronchiolitis profiles in children
Authors: Orianne Dumas, Jonathan M Mansbach, Tuomas Jartti, Kohei Hasegawa, Ashley F Sullivan, Pedro A Piedra, Carlos A Camargo
Journal: Thorax (2016)

Although bronchiolitis is generally considered a single disease, recent studies suggest heterogeneity. We aimed to identify severe bronchiolitis profiles using a clustering approach.We analysed data from two prospective, multicentre cohorts of children younger than 2 years hospitalised with bronchiolitis, one in the USA (2007-2010 winter seasons, n=2207) and one in Finland (2008-2010 winter seasons, n=408). Severe bronchiolitis profiles were determined by latent class analysis, classifying children based on clinical factors and viral aetiology.In the US study, four profiles were identified. Profile A (12%) was characterised by history of wheezing and eczema, wheezing at the emergency department (ED) presentation and rhinovirus infection. Profile B (36%) included children with wheezing at the ED presentation, but, in contrast to profile A, most did not have history of wheezing or eczema; this profile had the largest probability of respiratory syncytial virus infection. Profile C (34%) was the most severely ill group, with longer hospital stay and moderate-to-severe retractions. Profile D (17%) had the least severe illness, including non-wheezing children with shorter length of stay. Two of these profiles (A and D) were replicated in the Finnish cohort; a third group ('BC') included Finnish children with characteristics of profiles B and/or C in the US population.Several distinct clinical profiles (phenotypes) were identified by a clustering approach in two multicentre studies of children hospitalised for bronchiolitis. The observed heterogeneity has important implications for future research on the aetiology, management and long-term outcomes of bronchiolitis, such as future risk of childhood asthma.
The Effects of Adverse Growth Conditions on the Shedding of Carcinoembryonic Antigen from Cultured LS180 Colon Cancer Cells
Authors: G L Adams, M W Glacken
Journal: Cancer Communications (1990)

The synthesis and release of the tumor marker carcinoembryonic antigen (CEA) from the colon cancer cell line LS180 has previously been reported to be enhanced during the later stages of in vitro culture after growth has stopped. It has been suggested that CEA expression was inversely related to the growth rate for these cells (Kahan, B.D.; Rutzky, L.P.; Legrue, S.J.; Tom, B.H. Methods Cancer Res. 18:197-275; 1979 and Shi, Z.R.; Tsao, D.; Kim, Y.S. Cancer Res. 43:4045-4049; 1983). Our studies indicate, however, that while certain environmental perturbations that halt growth (e.g., glucose starvation and elevated temperatures) do indeed stimulate CEA expression and release; other growth-arresting conditions, such as oxygen starvation, have no effect. Replacement of spent or conditioned medium with fresh medium during the later culture stages resulted in a 10-fold decrease in CEA release, indicating that either depleted nutrients or accumulating cellular products (such as lactate or ammonium) trigger enhanced CEA production.
Frequency and spectrum of ROS1 resistance mutations in ROS1-positive lung cancer patients progressing on crizotinib.
Authors: Justin F. Gainor, Luc Friboulet, Satoshi Yoda, Leila Dardaei Alghalandis, Anna F. Farago, Jennifer Logan, Katherine Schultz, Lecia V. Sequist, Jeffrey A. Engelman, Alice Tsang Shaw
Journal: Journal of Clinical Oncology (2016)

9072 Background: ROS1 rearrangements define a distinct molecular subset of non-small cell lung cancer (NSCLC) and confer sensitivity to treatment with the ALK/ROS1/MET inhibitor crizotinib. Despite the initial activity of this agent, ROS1-positive cancers ultimately develop resistance to therapy. To evaluate mechanisms of resistance to crizotinib among ROS1-positive patients, we examined a series of repeat biopsies from ROS1-positive patients progressing on crizotinib. Methods: Medical records were reviewed and data extracted. Repeat biopsies were performed as part of routine clinical care or under institutional review board (IRB)-approved protocols. Specimens underwent Sanger-based sequencing of the ROS1 kinase domain or targeted next-generation sequencing (NGS). Results: We identified 10 ROS1-positive patients who underwent repeat biopsies following acquired resistance to crizotinib. One patient underwent resection of 2 separate central nervous system (CNS) metastases. The most common sites of tissue collection were the pleura/pleural fluid (N = 4; 36%), brain (N = 3; 27%), and lung (N = 2; 18%). The median number of prior lines of therapy was 1 (range 0-5). Median progression-free survival (PFS) on crizotinib was 10.0 months (95% CI 5.77-26.37 months). A majority of patients (N = 7; 63.6%) underwent repeat biopsies while still on crizotinib. ROS1 resistance mutations were identified in 5/11 (45%) specimens, including 5/8 (62.5%) non-CNS tissue samples. ROS1 resistance mutations were found at 2 residues: G2032R in 4 (36%) specimens and D2033N in 1 (9%) specimen. 3/6 samples that were negative for ROS1 resistance mutations underwent targeted NGS using Snapshot, revealing no additional significant genetic alterations. Conclusions: ROS1 resistance mutations are relatively frequent alterations in ROS1-positive lung cancers progressing on crizotinib, particularly among patients with disease progression outside of the CNS. The ROS1 G2032R solvent front mutation appears to be a dominant resistance mutation, underscoring the need for clinical development of next-generation ROS1 inhibitors with activity against this alteration.
Effect of High-Dose Methotrexate (HD-MTX) Vs Capizzi Methotrexate/Pegaspargase (C-MTX/ASNase) on Osteonecrosis (ON) Incidence in Children and Young Adults with T-Acute Lymphoblastic Leukemia (T-ALL): Results of Children’s Oncology Group (COG) Study AALL0434
Authors: Leonard A. Mattano, Meenakshi Devidas, Si Chen, Natia Esiashvili, Barbara Asselin, Naomi J. Winick, Mignon Loh, Elizabeth A Raetz, Stephen Hunger, William L. Carroll, Stuart S. Winter, Kimberly P. Dunsmore
Journal: Blood (2014)
Extra-anatomical intraduodenal endoscopic–radiologic biliary rendezvous for treatment of iatrogenic complete stenosis of the common bile duct
Authors: Bruno Meduri, Serge Derhy, Parag Dhumane, Jean-Loup Dumont, Thierry Tuszynski, Bertrand Vergeau, Gianfranco Donatelli
Journal: Endoscopy (2015)

Minimally invasive radiologic–endoscopic recanalization or reconstruction of the common bile duct (CBD) for benign complete stenosis or complex iatrogenic lesions is routinely practiced at some tertiary centers [1] [2]. Various techniques have been reported, including endoscopic ultrasound (EUS)-guided insertion of a magnet through a previous choledochoduodenostomy [1] [2] [3] [4].
Observations on the Morphology and Histochemistry of the Mouse Pituitary Implanted in the Anterior Eye Chamber
Authors: Siperstein, Eleanor R., Greer, Monte A.
Journal: JNCI Journal of the National Cancer Institute (1956)

Observations on the Morphology and Histochemistry of the Mouse Pituitary Implanted in the Anterior Eye Chamber Get access Eleanor R. Siperstein, Eleanor R. Siperstein Endocrinology Branch, National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Monte A. Greer Monte A. Greer Endocrinology Branch, National Cancer Institute,5Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages 569–598, https://doi.org/10.1093/jnci/17.5.569 Published: 01 November 1956 Article history Received: 21 February 1956 Published: 01 November 1956
P-272 The international, open-label, multicenter phase 2 LAPACT trial of nab-paclitaxel (nab-P) plus gemcitabine (Gem) for patients with locally advanced pancreatic cancer (LAPC)
Authors: Hammel Pascal, Lacy Jill, Portales Fabienne, Sobrero Alberto, García-Paredes Beatriz, Kim Edward, Rivera Fernando, Manzano Jose Luis, Terrebonne Eric, Bathini Venu, Dowden Scot, Asselah Jamil, Shiansong Li Jack, Nydam Thomas, Kayitalire Louis, Philip Philip
Journal: Annals of Oncology (2016)
Predictors of outcomes of psychological treatments for disordered gambling: A systematic review
Authors: S.S. Merkouris, S.A. Thomas, C.J. Browning, N.A. Dowling
Journal: Clinical Psychology Review (2016)

This systematic review aimed to synthesise the evidence relating to pre-treatment predictors of gambling outcomes following psychological treatment for disordered gambling across multiple time-points (i.e., post-treatment, short-term, medium-term, and long-term). A systematic search from 1990 to 2016 identified 50 articles, from which 11 socio-demographic, 16 gambling-related, 21 psychological/psychosocial, 12 treatment, and no therapist-related variables, were identified. Male gender and low depression levels were the most consistent predictors of successful treatment outcomes across multiple time-points. Likely predictors of successful treatment outcomes also included older age, lower gambling symptom severity, lower levels of gambling behaviours and alcohol use, and higher treatment session attendance. Significant associations, at a minimum of one time-point, were identified between successful treatment outcomes and being employed, ethnicity, no gambling debt, personality traits and being in the action stage of change. Mixed results were identified for treatment goal, while education, income, preferred gambling activity, problem gambling duration, anxiety, any psychiatric comorbidity, psychological distress, substance use, prior gambling treatment and medication use were not significantly associated with treatment outcomes at any time-point. Further research involving consistent treatment outcome frameworks, examination of treatment and therapist predictor variables, and evaluation of predictors across long-term follow-ups is warranted to advance this developing field of research.
Inflammatory Disequilibrium in Stroke
Authors: Danica Petrovic-Djergovic, Sascha N. Goonewardena, David J. Pinsky
Journal: Circulation Research (2016)

Over the past several decades, there have been substantial advances in our knowledge of the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to the development of thrombolytic therapy as the cornerstone of current management of ischemic stroke, but there remains much to be learned about mechanisms of neuronal ischemic and reperfusion injury and associated inflammation. For ischemic stroke, novel therapeutic targets have continued to remain elusive. When considering modern molecular biological techniques, advanced translational stroke models, and clinical studies, a consistent pattern emerges, implicating perturbation of the immune equilibrium by stroke in both central nervous system injury and repair responses. Stroke triggers activation of the neuroimmune axis, comprised of multiple cellular constituents of the immune system resident within the parenchyma of the brain, leptomeninges, and vascular beds, as well as through secretion of biological response modifiers and recruitment of immune effector cells. This neuroimmune activation can directly impact the initiation, propagation, and resolution phases of ischemic brain injury. To leverage a potential opportunity to modulate local and systemic immune responses to favorably affect the stroke disease curve, it is necessary to expand our mechanistic understanding of the neuroimmune axis in ischemic stroke. This review explores the frontiers of current knowledge of innate and adaptive immune responses in the brain and how these responses together shape the course of ischemic stroke.
Downregulation Of FOXO1 Prevents Induction Of The Tumor Suppressor BLIMP-1 In Classical Hodgkin Lymphoma
Authors: Marion J. Vogel, Linka Xie, Hanfeng Guan, Clarissa D. Weitzer, Frank Leithäuser, Peter Moeller, Thomas Wirth, Alexey Ushmorov
Journal: Blood (2013)
Maurice Simeon Albin
Authors: Roger L Albin
Journal: BMJ (2016)

Maurice Albin was a pioneering figure in neuroanaesthesia and devoted his life to improving patient care.

Born in Brooklyn, New York, he was the son of immigrant Jewish parents. His character was influenced by several powerful currents. The Jewish tradition of life as a quest for ethical fulfilment, the reformist optimism of the New Deal, the cosmopolitanism of New York City, and the communal experience of the second world war were major factors in his early life. His native curiosity was encouraged by his free thinking father, and he received an outstanding education in New York City’s public schools. Maurice graduated from Abraham Lincoln High School on the eve of the American entry into the second world war.

He enlisted in the US army, serving with the first medical battalion, attached to the famous first infantry division. He experienced the Normandy campaign and the Battle of the Bulge. In 1946, awaiting demobilisation and transfer home from Britain, he …
Mantle-Cell Lymphoma (MCL) Cells Are Highly Sensitive To ABT-199 But Their Sensitivity May Be Altered By The Microenvironment Via The Up-Regulation Of Bcl-Xl and Bcl2A1
Authors: Cyrille Touzeau, Carole Brosseau, Christelle Dousset, Catherine Pellat-Deceunynck, Steven Le Gouill, Martine Amiot
Journal: Blood (2013)
Sunil Inderraj Handa
Authors: Sudhir Handa
Journal: BMJ (2016)

Sunil Inderraj Handa moved from Kenya to the UK to pursue a medical degree and career. He worked in haematology laboratories as a medical laboratory scientific officer to pay his way through university, as under the residence criteria he was not eligible for a grant; this led to a lifelong commitment to haematology. As an undergraduate he …
P2-020: Genetic characterictics of women lung adenocarcinoma
Authors: Tatsuo Ohira, Norio Nakajima, Koichi Yoshida, Yuka Kuwajima, Jitsuo Usuda, Shuji Ichinose, Sachio Maehara, Naohiro Kajiwara, Masahiro Tsuboi, Takashi Hirano, Harubumi Kato
Journal: Journal of Thoracic Oncology (2007)
GENO-31MOLECULAR GENETIC PROFILE OF ADULT PILOCYTIC ASTROCYTOMA: BRAF-FGFR GENOMIC ALTERATIONS AND ACTIVATION OF MAPK/ERK/mTOR PATHWAY
Authors: Pankaj Pathak, Anupam Kumar, Prerana Jha, Suvendu Purkait, Mohammed Faruq, Ashish Suri, Shashank Sharad Kale, Vaishali Suri, Mehar C. Sharma, Chitra Sarkar
Journal: Neuro-Oncology (2015)

Pilocytic astrocytoma (PA), a WHO grade I tumor, occurs rarely in adults and shows aggressive tumor behavior. However, their underlying molecular-genetic events are largely uncharacterized. Hence, we studied 59 adult PA patients of classical histology with MIB-1 LI from 1-5% (median age at diagnosis 30 yrs, age-range 19-69 yrs). BRAF alterations examined in 59 cases confirmed KIAA1549-BRAF fusion in 11(19%), BRAF-gain in 2(3.4%) by qRT-PCR, and BRAF-V600E mutation in 1(1.7%) case using direct sequencing. FGFR1-mutation and FGFR-TKD duplication were seen in 7/59(11.9%) and 3/59(5%) cases respectively. Notably, FGFR related genetic alterations were enriched in supratentorial region (8/25, 32%) as compared to other tumor locations (P = 0.01). The association of age with respect to FGFR1-mutation (Mean age ± SD: 37.2 ± 15) compared to cases with KIAA1549-BRAF (Mean age ± SD: 25.1 ± 4.1) was significant (P = 0.03). Further, BRAF + FGFR duplicate genetic alterations were identified in 3(5%) cases (all in supratentorial tumors). Overall 36% of adult PAs harbored BRAF and/or FGFR related genetic alterations. Immunopositivity of p-MAPK/p-MEK1 corresponding to MAPK/ERK pathway activation was found in all the cases examined. In total, mTOR activator, pS6-immunoreactivity of any degree was observed in 34/39(87%) of cases. Interestingly, cases with BRAF and/or FGFR related alteration showed significantly lower pS6 immunostaining (3/12, 25%) as compared to BRAF and/or FGFR wild-type (16/27;59%) (P = 0.04). This study represents the largest reported adult PA patient cohort molecularly profiled to date. PAs with classical histology occur in adults but harbor infrequent BRAF alterations but enriched FGFR alterations in most instances compared to pediatric. The activation of constitutive BRAF-FGFR related MAPK/ERK signaling along with mTOR appears to be an important oncogenic event in adult PAs and may be constituting to the aggressive tumor behavior of adults. Therefore this study provides a rationale for potential therapeutic advantage of targeting MAPK/ERK and mTOR pathway in adult PAs.
Note on the Splitting of α-α Diglycylaminopropionic Acid Hydrochloride in Extracts of Rat Hepatic Tissues
Authors: Mariano de Mingo, Jesse P. Greenstein
Journal: JNCI Journal of the National Cancer Institute (1947)

Note on the Splitting of α-α Diglycylaminopropionic Acid Hydrochloride in Extracts of Rat Hepatic Tissues Get access Mariano de Mingo, Mariano de Mingo Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein Jesse P. Greenstein chief biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 8, Issue 1, August 1947, Page 29, https://doi.org/10.1093/jnci/8.1.29 Published: 01 August 1947 Article history Received: 29 April 1947 Published: 01 August 1947