tbuckley/cabot-search huggingface dataset:
Unusual Sites of Malignancy
Authors: Giuseppe Longo, Leonardo Potenza, Nicola D’Apollo, Leonardo Ferrara, Giovanna Gandini, Marcello Bertesi, Giuseppe Torelli, Giovanni Emilia
Journal: Journal of Clinical Oncology (2001)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.5.1570 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11230500 Unusual Sites of Malignancy Case 1. Primary Non-Hodgkin's Lymphoma of the Hand in a Patient With Hepatitis C Infection Giuseppe LongoxGiuseppe LongoSearch for articles by this author , Leonardo PotenzaxLeonardo PotenzaSearch for articles by this author , Nicola D’ApolloxNicola D’ApolloSearch for articles by this author , Leonardo FerraraxLeonardo FerraraSearch for articles by this author , Giovanna GandinixGiovanna GandiniSearch for articles by this author , Marcello BertesixMarcello BertesiSearch for articles by this author , Giuseppe TorellixGiuseppe TorelliSearch for articles by this author , Giovanni EmiliaxGiovanni EmiliaSearch for articles by this author Show More University of Modena, Modena, Italy, Copyright © 2001 American Society of Clinical Oncology https://doi.org/10.1200/JCO.2001.19.5.1570 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
Vandetanib in pretreated patients with advanced non-small cell lung cancer-harboring RET rearrangement: a phase II clinical trial
Authors: S.-H. Lee, J.-K. Lee, M.-J. Ahn, D.-W. Kim, J.-M. Sun, B. Keam, T.M. Kim, D.S. Heo, J.S. Ahn, Y.-L. Choi, H.-S. Min, Y.K. Jeon, K. Park
Journal: Annals of Oncology (2016)
Acquired Pure Red Cell Aplasia Associated with Malignant Lymphomas: A Nationwide Cohort Study in Japan
Authors: Makoto Hirokawa, Ken-ichi Sawada, Naohito Fujishima, Fumio Kawano, Akiro Kimura, Takashi Watanabe, Ayako Arai, Toshimitsu Matsui, Shinji Nakao, Akio Urabe, Mitsuhiro Omine, Keiya Ozawa
Journal: Blood (2008)
Human Primary CD271+/CD45−/CD146−/Low and CD271+/CD45−/CD146+ Bone Marrow Cells Are Developmentally Closely-Related Stroma Stem Cells with Similar Functional Properties but Different In-Situ Localization.
Authors: Ariane Tormin, Ou Li, Jan Claas Brune, Stuart Walsh, Mats Ehinger, Nicholas Ditzel, Moustapha Kassem, Stefan Scheding
Journal: Blood (2010)
Roles of HLA-DR15 Alleles in the Pathogenesis of Acquired Aplastic Anemia (AA): DRB1*1502 Is in Linkages Disequilibrium with Unique Genes Which Determine Susceptibility to AA.
Authors: Chiharu Sugimori, Kanako Mochizuki, Xingmin Feng, Shinji Nakao
Journal: Blood (2006)
MTHFR 677CC/1298CC Genotypes Are Highly Associated with Chronic Myelogenous Leukemia: A Case-Control Study in Korea.
Authors: Hee Won Moon, Tae Young Kim, Bo Ra Oh, Hyun Chung Min, Han Ik Cho, Jae Hoon Lee, Sung Soo Yoon, Dong Soon Lee
Journal: Blood (2007)
Phase II Study of WEE1 Inhibitor AZD1775 Plus Carboplatin in Patients With <i>TP53</i>-Mutated Ovarian Cancer Refractory or Resistant to First-Line Therapy Within 3 Months
Authors: Suzanne Leijen, Robin M.J.M. van Geel, Gabe S. Sonke, Daphne de Jong, Efraim H. Rosenberg, Serena Marchetti, Dick Pluim, Erik van Werkhoven, Shelonitda Rose, Mark A. Lee, Tomoko Freshwater, Jos H. Beijnen, Jan H.M. Schellens
Journal: Journal of Clinical Oncology (2016)

Purpose AZD1775 is a first-in-class, potent, and selective inhibitor of WEE1 with proof of chemopotentiation in p53-deficient tumors in preclinical models. In a phase I study, the maximum tolerated dose of AZD1775 in combination with carboplatin demonstrated target engagement. We conducted a proof-of-principle phase II study in patients with p53 tumor suppressor gene ( TP53)-mutated ovarian cancer refractory or resistant (< 3 months) to first-line platinum-based therapy to determine overall response rate, progression-free and overall survival, pharmacokinetics, and modulation of phosphorylated cyclin-dependent kinase (CDK1) in skin biopsies. Patients and Methods Patients were treated with carboplatin (area under the curve, 5 mg/mL⋅min) combined with AZD1775 225 mg orally twice daily over 2.5 days every 21-day cycle until disease progression. Results AZD1775 plus carboplatin demonstrated manageable toxicity; fatigue (87%), nausea (78%), thrombocytopenia (70%), diarrhea (70%), and vomiting (48%) were the most common adverse events. The most frequent grade 3 or 4 adverse events were thrombocytopenia (48%) and neutropenia (37%). Of 24 patients enrolled, 21 patients were evaluable for efficacy end points. The overall response rate was 43% (95% CI, 22% to 66%), including one patient (5%) with a prolonged complete response. Median progression-free and overall survival times were 5.3 months (95% CI, 2.3 to 9.0 months) and 12.6 months (95% CI, 4.9 to 19.7), respectively, with two patients with ongoing response for more than 31 and 42 months at data cutoff. Conclusion To our knowledge, this is the first report providing clinical proof that AZD1775 enhances carboplatin efficacy in TP53-mutated tumors. The encouraging antitumor activity observed in patients with TP53-mutated ovarian cancer who were refractory or resistant (< 3 months) to first-line therapy warrants further development.
Senior surgeon suspended for failing to spot indicators of severity
Authors: Clare Dyer
Journal: BMJ (2016)

A senior consultant surgeon has been suspended from the UK medical register for 12 months for failings in the care of five patients over a three year period between 2010 and 2013.

Ian Haynes, who qualified in 1972 and had a hitherto blameless career, was charged with a catalogue of failings relating to five unnamed patients at George Eliot Hospital in Nuneaton, Warwickshire. Many of the charges were found not proved by a medical practitioners’ tribunal but those that remained were judged sufficient to justify a finding of serious misconduct.

The bile duct of one patient was injured …
Nelarabine in Combination with Etoposide and Cyclophosphamide Is Active in First Relapse of Childhood T-Acute Lymphocytic Leukemia (T-ALL) and T-Lymphoblastic Lymphoma (T-LL)
Authors: James Whitlock, Luciano dalla Pozza, John M Goldberg, Lewis B. Silverman, David S. Ziegler, Andishe Attarbaschi, Patrick Brown, Rebecca A Gardner, Paul S. Gaynon, Raymond J. Hutchinson, Leigh J. Marcus, Yoav H. Messinger, Kirk R. Schultz, Jeannette Vandergiessen, Elena Eckroth, Franco Locatelli, C Michel Zwaan, Brent L. Wood, Richard Sposto, Lia Gore
Journal: Blood (2014)
Novel rechargeable calcium phosphate nanoparticle-containing orthodontic cement
Authors: Xian-Ju Xie, Dan Xing, Lin Wang, Han Zhou, Michael D Weir, Yu-Xing Bai, Hockin HK Xu
Journal: International Journal of Oral Science (2016)

White spot lesions (WSLs), due to enamel demineralization, occur frequently in orthodontic treatment. We recently developed a novel rechargeable dental composite containing nanoparticles of amorphous calcium phosphate (NACP) with long-term calcium (Ca) and phosphate (P) ion release and caries-inhibiting capability. The objectives of this study were to develop the first NACP-rechargeable orthodontic cement and investigate the effects of recharge duration and frequency on the efficacy of ion re-release. The rechargeable cement consisted of pyromellitic glycerol dimethacrylate (PMGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). NACP was mixed into the resin at 40% by mass. Specimens were tested for orthodontic bracket shear bond strength (SBS) to enamel, Ca and P ion initial release, recharge and re-release. The new orthodontic cement exhibited an SBS similar to commercial orthodontic cement without CaP release (P>0.1). Specimens after one recharge treatment (e.g., 1 min immersion in recharge solution repeating three times in one day, referred to as "1 min 3 times") exhibited a substantial and continuous re-release of Ca and P ions for 14 days without further recharge. The ion re-release did not decrease with increasing the number of recharge/re-release cycles (P>0.1). The ion re-release concentrations at 14 days versus various recharge treatments were as follows: 1 min 3 times>3 min 2 times>1 min 2 times>6 min 1 time>3 min 1 time>1 min 1 time. In conclusion, although previous studies have shown that NACP nanocomposite remineralized tooth lesions and inhibited caries, the present study developed the first orthodontic cement with Ca and P ion recharge and long-term release capability. This NACP-rechargeable orthodontic cement is a promising therapy to inhibit enamel demineralization and WSLs around orthodontic brackets.
New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective
Authors: Benedetta Allegranzi, Bassim Zayed, Peter Bischoff, N Zeynep Kubilay, Stijn de Jonge, Fleur de Vries, Stacey M Gomes, Sarah Gans, Elon D Wallert, Xiuwen Wu, Mohamed Abbas, Marja A Boermeester, E Patchen Dellinger, Matthias Egger, Petra Gastmeier, Xavier Guirao, Jianan Ren, Didier Pittet, Joseph S Solomkin
Journal: The Lancet Infectious Diseases (2016)
Reduced Intensity Conditioning (RIC) with Cladribine, Busulfan and 4 Gy Total Body Irradiation (TBI) for Bone Marrow Transplantation (BMT) from an HLA-Matched Unrelated Donor (URD): A Prospective Multi-Institutional Clinical Trial.
Authors: Sung-Won Kim, Masayuki Hino, Kazuo Hatanaka, Yasunori Ueda, Ryuji Tanosaki, Makoto Hirokawa, Shin-ichiro Mori, Kazunori Nakase, Toshiro Ito, Chihiro Shimazaki, Yasukazu Kawai, Kazutaka Sunami, Hirohisa Nakamae, Toshiharu Tamaki, Chisato Mizutani, Masahiro Kami, Takahiro Fukuda, Kinuko Tajima, Koji Nagafuji, Shuichi Taniguchi, Yoichi Takaue, Mine Harada
Journal: Blood (2006)
Unusual Sites of Involvement by Hematologic Malignancies
Authors: W. Y. Au, G. C.F. Chan, C. S. Chim, T. W. Shek, G. C. Ooi, W. K. Ho, Y. L. Kwong
Journal: Journal of Clinical Oncology (2001)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.19.3993 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11579122 Unusual Sites of Involvement by Hematologic Malignancies Case 3. External Auditory Canal Tumor: A Rare Chloroma in Acute Promyelocytic Leukemia With a Complete Response to Arsenic Trioxide W. Y. AuxW. Y. AuSearch for articles by this author , G. C.F. ChanxG. C.F. ChanSearch for articles by this author , C. S. ChimxC. S. ChimSearch for articles by this author , T. W. ShekxT. W. ShekSearch for articles by this author , G. C. OoixG. C. OoiSearch for articles by this author , W. K. HoxW. K. HoSearch for articles by this author , Y. L. KwongxY. L. KwongSearch for articles by this author Show More Queen Mary Hospital, Hong Kong https://doi.org/10.1200/JCO.2001.19.19.3993 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
The Genomes of Two Bat Species with Long Constant Frequency Echolocation Calls
Authors: Dong Dong, Ming Lei, Panyu Hua, Yi-Hsuan Pan, Shuo Mu, Guantao Zheng, Erli Pang, Kui Lin, Shuyi Zhang
Journal: Molecular Biology and Evolution (2016)

Bats can perceive the world by using a wide range of sensory systems, and some of the systems have become highly specialized, such as auditory sensory perception. Among bat species, the Old World leaf-nosed bats and horseshoe bats (rhinolophoid bats) possess the most sophisticated echolocation systems. Here, we reported the whole-genome sequencing and de novo assembles of two rhinolophoid bats-the great leaf-nosed bat (Hipposideros armiger) and the Chinese rufous horseshoe bat (Rhinolophus sinicus). Comparative genomic analyses revealed the adaptation of auditory sensory perception in the rhinolophoid bat lineages, probably resulting from the extreme selectivity used in the auditory processing by these bats. Pseudogenization of some vision-related genes in rhinolophoid bats was observed, suggesting that these genes have undergone relaxed natural selection. An extensive contraction of olfactory receptor gene repertoires was observed in the lineage leading to the common ancestor of bats. Further extensive gene contractions can be observed in the branch leading to the rhinolophoid bats. Such concordance suggested that molecular changes at one sensory gene might have direct consequences for genes controlling for other sensory modalities. To characterize the population genetic structure and patterns of evolution, we re-sequenced the genome of 20 great leaf-nosed bats from four different geographical locations of China. The result showed similar sequence diversity values and little differentiation among populations. Moreover, evidence of genetic adaptations to high altitudes in the great leaf-nosed bats was observed. Taken together, our work provided a useful resource for future research on the evolution of bats.
Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid
Authors: Suhua Li, Parshotam Madan, Senshang Lin
Journal: Asian Journal of Pharmaceutical Sciences (2016)

The purpose of this study was to investigate the effect of ionization of drug on drug solubilization in SMEDDS (self-microemulsifying drug delivery system) prepared using Capmul MCM and caprylic acid. Solubilization capacity of blank SMEDDS dispersions for danazol, indomethacin and haloperidol as model drugs was determined. Based on the outcomes of solubilization capacity study, drug-loaded SMEDDS formulations were prepared and subjected to dispersion/precipitation study and droplet size analysis. Blank SMEDDS dispersions exhibited the highest solubilization capacity for haloperidol followed by indomethacin and danazol. Furthermore, the solubilization of the three drugs in blank SMEDDS dispersions was explained by a modified mathematical model. Dispersion/precipitation studies indicate that drug-loaded SMEDDS formulations exhibited superiority in solubilizing the drugs in comparison to their respective drug powder. In addition, indomethacin and haloperidol were found to reduce the droplet size of the microemulsions while danazol did not affect droplet size formation for drug-loaded SMEDDS formulations. These findings suggest that ionization of drug affects drug solubilization, droplet size formation, drug loading and drug dispersion/precipitation profiles for the SMEDDS formulations.
A Cause-Specific Hazard Rate Analysis of Prognostic Factors Among 199 Adults With Acute Lymphoblastic Leukemia
Authors: Jeffrey Gaynor, Douglass Chapman, Claudia Little, Susan McKenzie, Wendy Miller, Michael Andreeff, Zalmen Arlin, Ellin Berman, Sanford Kempin, Timothy Gee, Bayard Clarkson
Journal: Journal of Clinical Oncology (1988)

The statement in Table 2 (p 1018) of the article by Gaynor et al published in the June 1988 issue (6:1014–1030), "among factors associated with a shorter remission duration" should have read, "among factors associated with remission duration." The association listed directly below that statement, "high log (WBC) with Null or B cell ALL" should have read, "high log (WBC) with T cell ALL."
The global burden of women’s cancers: a grand challenge in global health
Authors: Ophira Ginsburg, Freddie Bray, Michel P Coleman, Verna Vanderpuye, Alexandru Eniu, S Rani Kotha, Malabika Sarker, Tran Thanh Huong, Claudia Allemani, Allison Dvaladze, Julie Gralow, Karen Yeates, Carolyn Taylor, Nandini Oomman, Suneeta Krishnan, Richard Sullivan, Dominista Kombe, Magaly M Blas, Groesbeck Parham, Natasha Kassami, Lesong Conteh
Journal: The Lancet (2016)
Imatinib Mesylate (Gleevec®) Produces Responses in Patients with Relapsed/Refractory Waldenstrom’s Macroglobulinemia.
Authors: Jacob D. Soumerai, Kelly E. O’Connor, Leukothea M. Ioakimidis, Christopher J. Patterson, Bryan T. Ciccarelli, Renee Leduc, Zachary R. Hunter, Marybeth Nelson, Aldo M. Roccaro, Xavier Leleu, Evdoxia Hatjiharissi, Sophia Adamia, Lian Xu, Irene M. Ghobrial, Steven P. Treon
Journal: Blood (2007)
CUSTOMISED SPORT INJURY REHABILITATION WITH YOGA AND PHYSIOTHERAPY FOR ACL - 12 WEEK REHABILITATION PROGRESS OF AN INJURED YOUNG ALPINE SKIER
Authors: S Ravi
Journal: British Journal of Sports Medicine (2016)

Perception of the usefulness /value of yoga as an adjunct intervention is a significant factor for the injured athlete's adherence to the customised sport injury rehabilitation program. The findings from 12 week rehabilitation progress assessment post Anterior Cruciate Ligament (ACL) reconstruction of an injured skier, highlight improvement in the injury rehabilitation goals which influence the performance goals of the injured athlete. A customised program was designed for the injured athlete with a 30 minute yoga protocol as an adjunct intervention, thrice a week along with 90 minute physical therapy session. IKDC score improved from 49.4 to 63.2. Range of Motion (ROM) of the injured right knee improved from −3 to normal, knee flexion increased by 20 deg, external rotation flexion enhanced (active 20 deg and passive 10 deg), passive hip flexion increased by 15 deg. Muscle test for hip extension increased from 4 to 5, flexion (from 3+ to 5), knee flexion (from 3 to 4), knee extension (3+ to 5). The perceived value of the injured athlete to practice yoga as part of rehabilitation is 5.8 whereas the perceived choice is 3.9 on a 7 point scale of Perception of Activity. While yoga and physical therapy improve flexibility, muscle strength, stability and balance of the injured athlete, perception about usefulness of the customised yoga and physical therapy influences adherence to rehabilitation and effective participation in the rehabilitation program. Biopsychosocial model (Brewer et al 2002) helps to understand rehabilitation of sport injury rehabilitation. Yoga and physiotherapy as a combined intervention, could enhance the biological and psychological factors that have a significant effect on the intermediate biopsychological outcomes. In this research, knowledge about usefulness of yoga in sport injury treatment could benefit the sport medicine and physiotherapy fraternity to include yoga as an adjunct intervention. Collaboration of physiotherapists, yoga professionals, doctors and coaches with an athlete-centric approach might help injured athletes to enhance adherence to sport injury rehabilitation programs. Further studies are warranted to measure long term effect of yoga on sport injury rehabilitation and prevention of non-contact injuries of athletes.
Somatic cancer variant curation and harmonization through consensus minimum variant level data
Authors: Deborah I. Ritter, Sameek Roychowdhury, Angshumoy Roy, Shruti Rao, Melissa J. Landrum, Dmitriy Sonkin, Mamatha Shekar, Caleb F. Davis, Reece K. Hart, Christine Micheel, Meredith Weaver, Eliezer M. Van Allen, Donald W. Parsons, Howard L. McLeod, Michael S. Watson, Sharon E. Plon, Shashikant Kulkarni, Subha Madhavan
Journal: Genome Medicine (2016)

To truly achieve personalized medicine in oncology, it is critical to catalog and curate cancer sequence variants for their clinical relevance. The Somatic Working Group (WG) of the Clinical Genome Resource (ClinGen), in cooperation with ClinVar and multiple cancer variant curation stakeholders, has developed a consensus set of minimal variant level data (MVLD). MVLD is a framework of standardized data elements to curate cancer variants for clinical utility. With implementation of MVLD standards, and in a working partnership with ClinVar, we aim to streamline the somatic variant curation efforts in the community and reduce redundancy and time burden for the interpretation of cancer variants in clinical practice. We developed MVLD through a consensus approach by i) reviewing clinical actionability interpretations from institutions participating in the WG, ii) conducting extensive literature search of clinical somatic interpretation schemas, and iii) survey of cancer variant web portals. A forthcoming guideline on cancer variant interpretation, from the Association of Molecular Pathology (AMP), can be incorporated into MVLD. Along with harmonizing standardized terminology for allele interpretive and descriptive fields that are collected by many databases, the MVLD includes unique fields for cancer variants such as Biomarker Class, Therapeutic Context and Effect. In addition, MVLD includes recommendations for controlled semantics and ontologies. The Somatic WG is collaborating with ClinVar to evaluate MVLD use for somatic variant submissions. ClinVar is an open and centralized repository where sequencing laboratories can report summary-level variant data with clinical significance, and ClinVar accepts cancer variant data. We expect the use of the MVLD to streamline clinical interpretation of cancer variants, enhance interoperability among multiple redundant curation efforts, and increase submission of somatic variants to ClinVar, all of which will enhance translation to clinical oncology practice.
Widespread Amyloidosis Around Major Joints on 18F-FDG PET/CT
Authors: Fuqiang Shao, Mingshan Zhang, Yu Wang, Yuting Zou, Yue Chen
Journal: Clinical Nuclear Medicine (2016)

A 62-year-old woman had an elevated serum creatinine. Physical examination detected a left inguinal mass, suggestive of possible malignancy. An F-FDG PET/CT was performed to evaluate the nature of the mass. The images showed multiple juxta-articular foci of increased activity in all extremities. Amyloidosis was confirmed histopathologically following the biopsy.
Megakaryocytic and Platelet Dysplasia in MDS Patients as Detected by Multiparameter Flow Cytometry Immunophenotyping
Authors: Alex Freire Sandes, Mihoko Yamamoto, Sandra Quijano, Antonio López, Maria de Lourdes L.F. Chauffaille, Tsutomu Oguro, Sergio Matarraz, Marçal C.A. Silva, Eliza Y.S. Kimura, Alberto Orfao
Journal: Blood (2008)
Triple Intrathecal Therapy Alone Was Delayed until the Disappearance of Blasts From Peripheral Blood in Children with Acute Lymphoblastic Leukemia: The Experience of a Single Hospital in Taiwan
Authors: Hsi-Che Liu, Ting-Chi Yeh, Jen-Yin Hou, Kuan-Hao Chen, Ting-Huan Huang, Der-Cherng Liang
Journal: Blood (2012)
Country-wide prevalence of ESBL-producing Enterobacteriaceae in 2009
Authors: Dennis S Hansen, F. Hansen, H. Schumacher, Kristian Schønning, Sanne Grønvall Kjær Hansen, Kurt Fuursted, T Højbjerg, H.K. Johansen, Jens Kjølseth Møller, B.H. Kallesøe, Rolf Magnus Arpi, Esad Dzajic, Ole Heltberg, A.M. Hammerum
Journal: Clinical Microbiology and Infection (2011)
Quantum Dot Based Duplex In Situ Hybridisation for Gene Expression Profiling.
Authors: Eleni Tholouli, Dolores Di Vizio, Fionnuala O’Connell, Massimo Loda, David Twomey, Todd Golub, Richard Levenson, Judith A. Hoyland, John A.L. Yin, Richard Byers
Journal: Blood (2005)
COST-EFFECTIVENESS OF PANITUMUMAB PLUS BEST SUPPORTIVE CARE (BSC) COMPARED WITH BSC ALONE IN CHEMOREFRACTORY METASTATIC COLORECTAL CANCER (MCRC) PATIENTS (PTS) WITH WILD-TYPE (WT) KRAS TUMOR STATUS IN THE NETHERLANDS
Authors: C Graham, R Borker, M Oppe, C Uyl-de Groot, B Barber, A Brogan, R Amado, Marc Peeters, G Devercelli
Journal: Annals of Oncology (2008)