tbuckley/cabot-search huggingface dataset:
Acquired Agammaglobulinemia after a Life-Threatening Illness with Clinical and Laboratory Features of Infectious Mononucleosis in Three Related Male Children
Authors: A. J. Provisor, J. J. Iacuone, R.R. Chilcote, R.G. Neiburger, F.G. Crussi, R.L. Baehner
Journal: New England Journal of Medicine (1975)

Three males in one family (two siblings and one maternal cousin) had an illness with cervical adenopathy, hepatosplenomegaly, and a fulminant febrile course. In the two survivors agammaglobulinemia developed. One of them became ill at the age of six months and had an Epstein-Barr-virus antibody titer of 1:10 during illness and convalescence. The white-cell count was 120,000 with 90 per cent lymphocytes, most being atypical and forming increased numbers of sheep erythrocyte rosettes. IgM was elevated, IgA normal and IgG decreased. Subsequently, all immunoglobulins were absent, and the Epstein-Barr-virus antibody titer became negative. Peripheral B-cell number remained normal, but abnormal lymph-node architecture associated with failure to respond to antigenic challenge indicated B-cell dysfunction. The pathogenesis of this entity may involve an abnormal T-cell response to transformation of B cells by Epstein-Barr virus, leading to B-cell dysfunction and agammaglobulinemia.
U.S. Sperm Trend Conclusions
Authors: William H. James
Journal: Environmental Health Perspectives (1999)

ConclusionsThe letter written by Heinze (1) has seri- ous shortcomings.Heinze wrote that There is not a single study of healthy men from any fertility center or sperm bank that has reported a decline in sperm counts in the United States.This is not true.A number of such studies exist.Leto and Frensilli (2) documented a decline in sperm counts in potential sperm donors from all over the United States in a longitudinal study.Heinze stated thatA study by MacLeod and Wang (3) indicates that sperm counts have remained constant in New York since 1938.That study was dated 1979 and was on men ascertained at a fertility center.Although their sperm counts were stable over the years preceding 1979, it does not necessarily follow that sperm counts of fertile men were stable too.
SAT0074 Smoking Cessation Significantly Reduces Failure of BIOLOGICS (BIO)-Treatment in Rheumatoid Arthritis (RA): from the “Ninja” Registry Cohort of Japanese Patients:
Authors: Y. Saeki, T. Matsui, K. Kagawa, S. Ohshima, M. Matsushita, E. Tanaka-Kudo, S.-I. Tsuji, M. Yoshimura, A. Watanabe, S. Teshigawara, M. Katayama, Y. Katada, Y. Harada, A. Yura, J. Hashimoto, S. Tohma
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Biologics (Bio) targeting cytokines and lymphocytes have shown outstanding efficacy and become a master of drug in the treatment of rheumatoid arthritis (RA). However, some issues remain to be addressed and resolved, including adverse effects (AE) such as serious infections, therapeutic failure (Failure) and high cost. On the other hand, cumulative evidence has suggested that some genetic and environmental factors might affect responsiveness of anti-rheumatic drugs, including Bio. Smoking is thought to be one of crucial environmental factors. <h3>Objectives</h3> To investigate the influence of smoking on Bio-treatment in RA, the association between the causes of discontinuation of Bio and smoking was analyzed by using the data from the “NinJa” Registry cohort of Japanese RA patients. <h3>Methods</h3> The causes of discontinuation of Bio-use were analyzed by using the data of the “NinJa” from 2007 to 2012. The “NinJa” Registry is one of the largest Japanese RA patient cohort and now consists of the clinical data of 11,940 patients from more than 30 hospitals. Smoking habit was assessed by a questionnaire (60.1% of the total patients answered) and the patients were divided into three groups as smoking, non-smoking, smoking cessation. The association between the causes of discontinuation of Bio (Failure, AE, Remission) and smoking habit was analyzed statistically and shown as odds ratio (OR). <h3>Results</h3> 3,187 (26.7%) of the total registered patients were treated with one or more Bio during 6 years. Among them, 584 (18.3%), 1,321 (41.4%), 397 (12.5%), 589 (18.5%), 223 (7.0%), and 73 (2.3%) of the patients were treated with IFX, ETN, ADA, TCZ, ABT and GLM respectively. The total numbers and percentages of discontinuation of Bio-use were 335 (57.4%), 418 (31.6%), 220 (55.4%), 162 (27.5%), 65 (29.1%) and 42 (57.5%) in IFX, ETN, ADA, TCZ, ABT and GLM respectively. The causes of discontinuation were analyzed according to four categories, Failue, AE, Remission, and others. The association between the causes of discontinuation of Bio (Failure, AE, Remission) and smoking habit was shown in Table. Failure in the smoking group was significantly more frequent compared to both in the non-smoking and smoking cessation groups. <h3>Conclusions</h3> In RA, smoking habit might affect responsiveness of Bio-treatment and in addition smoking cessation might reduce failure of Bio-treatment. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1441
Abstract 3746: Prostate stem cell antigen is associated with gastric cancer in Caucasians: Results from the EPIC-EURGAST study
Authors: Nuria Sala, Xavier Muñoz, Noemie Travier, Antonio Agudo, Eric J. Duell, Victor Moreno, Nadia Garcia, Gabriel Capella, Elio Riboli, Carlos A. Gonzalez
Journal: Cancer Research (2011)

Abstract Background. A genome-wide study performed in a Japanese population identified a strong association between SNP rs2294008 (Met1Thr) in the Prostate Stem Cell Antigen gene (PSCA) and diffuse-type gastric cancer (GC). This association has been validated in different Asian populations but no study has yet been conducted in Caucasians. Objective. To analyze the association between PSCA variants and gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods. As part of a wider study in which we used the Illumina GoldenGate technology to genotype 1287 SNPs in 249 candidate genomic regions, we genotyped six tagSNPs covering the PSCA gene region in 411 incident gastric adenocarcinoma cases and 1530 matched controls from a nested case-control study in the European EPIC cohort. Among GC cases, 28% were in the cardia or in the gastroesophageal junction, 48% were noncardia and 24% were unspecified. Regarding the histological type, 36% were intestinal, 35% were diffuse and 29% were unspecified. After quality control analysis and data filtering, association was analyzed by unconditional logistic regression, adjusting for age, sex and country. Results. The T allele of rs2294008 in PSCA (frequency of 0.44 in controls and 0.53 in cases) was found to be a significant risk factor for GC (per allele OR=1.42, 95%CI:1.23-1.6; uncorrected p-value=6.5×10-6; Bonferroni adjusted p-value=0.0126). The A allele of rs12155758 also appeared to increase GC risk, while the C allele of rs9297976, in LD with rs2294008, was inversely associated with GC. These 3 SNPs jointly cover 92% of the common variation (MAF≥0.05) within 10 kb around PSCA in Caucasians. Haplotype analysis did not provide additional information. No statistically significant differences were observed in the effect of rs2294008 between diffuse (OR=1.54, 95%CI:1.20-1.96; p-value=0.0005) and intestinal-types (OR=1.52, 95%CI:1.20-1.93; p-value=0.0005), or between cardia (OR=1.19, 95%CI:0.91-1.56; p-value=0.20) and noncardia (OR=1.47, 95%CI:1.19-1.81; p-value=0.0003) sub-sites, although the associations were stronger in noncardia GC. Conclusions. Variation in the promoter region of PSCA, specifically the functional rs2294008 variant, is associated with GC risk in Caucasians. Supported by “LaCaixa” (BM06-130-0); Spanish Ministry of Health (PI070130 and PI081420); European Commission FP5 (ref.QLG1-CT-2001-01049). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3746. doi:10.1158/1538-7445.AM2011-3746
GLOBAL LONGITUDINAL STRAIN AT PRESENTATION IS PROGNOSTIC OF SUBSEQUENT LEFT VENTRICULAR RECOVERY IN PATIENTS WITH PERIPARTUM CARDIOMYOPATHY
Authors: Masataka Sugahara, Dennis McNamara, Navin Rajagopalan, Joan Briller, Julie Damp, Gretchen Wells, Mark Drazner, Lori Blauwet, Leslie Cooper, John Gorcsan
Journal: Journal of the American College of Cardiology (2016)
Abstract 321: Chromosomal and molecular genomic analysis of spontaneously transformed murine colon epithelial cells
Authors: Nicole E. McNeil*, Hesed M. Padilla-Nash*, Quang Tri Nguyen, Thomas Ried
Journal: Cancer Research (2010)

Abstract Introduction: Colorectal cancer (CRC) represents one of the most common malignancies in the United States. The pathological progression from adenoma to carcinoma is accompanied by distinct and reproducible genetic alterations. Here we present a novel mouse model system for the sequential steps of tumorigenesis. This system will be helpful for functional validation of novel therapeutic targets in CRC. Purpose: The aim of this study is to delineate the stage-specific genomic alterations and transcriptional deregulation that are associated with the spontaneous progression of normal murine colon epithelial cells to immortalized, transformed, and eventually tumorigenic cell lines. Methods: Normal epithelial colon cells were selectively isolated from the large intestine from eight different isogenic five-six week old C57BL/6 mice. Primary colon cells were grown with reduced serum concentration while a fraction of these normal cells were cryopreserved for further analysis. The cells were sequentially recovered from culture based on distinct morphological changes: first, when the cells were in the pre-immortal stage as cells were actively growing; second, as the cells bypassed crisis, formed colonies and became immortal; third, at early transformation, as the cells first formed foci; fourth, mid-transformed (higher proliferation rates, later passages); and finally, as cells became less adherent, and exhibiting multiple foci. The cells were then analyzed using molecular cytogenetic methods (SKY and arrayCGH), and using global gene expression profiling. Results: Using Spectral Karyotyping (SKY) we identified clonal chromosomal aberrations and recurrent chromosome imbalances, specifically reported here for late transformed cells and in tumor cells. Array CGH (aCGH) demonstrated a specific pattern of whole chromosome copy number gains (i.e. MMU10 and MMU15 which contain Mdm2 and Myc, respectively) and losses (ex. MMU4 which contains tumor suppressor gene p16/Ink4a/Cdkn2a) at the various stages of cellular transformation. Gene expression microarray identified the deregulation of specific genes that defined genomic signatures at each stage of transformation. Two of the eight late transformed cell lines gave rise to tumors in a nude mouse assay. Conclusion: We present a novel mouse model of CRC that recapitulates the sequential steps of human colorectal tumorigenesis which affords us the possibility to experimentally test potential rational intervention strategies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 321.
Abstract 3440: YWHAZ promotes slug transcription activity and lung cancer metastasis
Authors: Ching-Hsien Chen, Hsuan-Yu Chen, Sheng-Yi Lin, Meng-Feng Tsai, Sung-Liang Yu, Jeremy Chen
Journal: Cancer Research (2011)

Abstract Metastasis is a major cause leading to mortality for lung cancer patients and gene copy variation is one common mechanism contributing to human malignancies. To identify the novel metastasis-related genes, an approach combined array comparative genomic hybridization and expression microarray was applied in a lung cancer invasion cell model. YWHAZ was identified as a potential candidate, which plays an important role in a wide variety of cellular processes. Nevertheless, its role and underlying mechanism in lung cancer metastasis remain unclear. In this study, we found that YWHAZ promotes cell proliferation, anchorage-independent growth, invasion and migration in vitro, as well as tumorigenesis and metastasis in vivo. It not only increases cell protrusions and branchings but also induces epithelial-mesenchymal transition. Furthermore, YWHAZ associates with β-catenin and enhances slug expression which is regulated by the β-catenin/TCF signaling pathway in lung cancer cells. Our findings demonstrate that YWHAZ plays a critical role in promoting invasion and metastasis of human lung adenocarcinoma cells, which might provide new insight into the future treatment of lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3440. doi:10.1158/1538-7445.AM2011-3440
Abstract 2663: Phase I study of azacitidine and cisplatin in patients with advanced head and neck or non-small cell lung cancer
Authors: Yu-Min Liao, Hamid Mirshahidi, Kangling Zhang, Saied Mirshahidi, Stephen Williamson, Chung-Tsen Hsueh
Journal: Cancer Research (2012)

Abstract Background: DNA hypomethylation agents such as azacitidine may be used for epigenetic sensitization of cisplatin treatment, and therefore leading to improvement of treatment outcome. We conducted a phase I study of azacitidine and cisplatin to determine safety, toxicity, and effect of global DNA methylation in peripheral blood mononuclear cells. Methods: Azacitidine was given as subcutaneous injection daily from day 1 to day 5, and cisplatin was given at 75 mg/m2 IV on day 8. The treatment was repeated every 28 days. Four patients received azacitidine 37 mg/m2 daily from day 1 to day 5 on dose level 1. Two patients were treated on dose level 2, and received azacitidine 60 mg/m2 daily from day 1 to day 5. Peripheral blood samples were collected before and after azacitidine treatment. DNA was extracted from peripheral blood mononuclear cells, and subjected to gas chromatography/mass spectrometry to measure the level of global DNA methylation, as reflected by the ratio of 5-methylcytosine to the sum of 5-methylcytosine and cytosine. Results: No patient had dose-limiting toxicities. Four patients completed at least 2 cycles of treatment, and were evaluated for clinical response by CT scan and DNA methylation effect. One partial response was noted in patient with metastatic tongue cancer after 2 cycles of treatment on dose level 1 of azacitidine. This patient received total 3 cycles of treatment and achieved free of progression for about 15 months on chemotherapy holiday. One patient with recurrent salivary gland cancer achieved stable disease after 2 cycles of treatment on dose level 2, and maintained in free of progression for more than 6 months after 4 cycles of treatment. There was inhibition of global DNA methylation after azacitidine treatment ranging from 12 to 36% in all 4 patients. Furthermore, the inhibition of global DNA methylation was associated with the increase of fetal hemoglobin in patients’ peripheral blood. Conclusion: Sequential administration of azacitidine followed by cisplatin is well tolerated, and demonstrates encouraging activity in patients with advanced head and neck cancer. This combination deserves further clinical investigation to study the correlation between clinical response and biological effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2663. doi:1538-7445.AM2012-2663
FRI0225 Introduction of 3D Printing into Rheumatology –Transferring Images from Arthritic Joints into Models
Authors: A. Kleyer, A.J. Hueber, J. Rech, F. Stemmler, G. Kroenke, D. Simon, G. Schett
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Three dimensional (3D) Prototyping allows the creation of individual 3D objects with almost any material. It is a rapid emerging technology, easy to use and quickly accessible. <h3>Objectives</h3> In this experimental study we tested the feasibility to generate exact models of joints of patients suffering from rheumatoid arthritis and healthy controls. <h3>Methods</h3> Using a high resolution CT (Xtreme CT, Scanco) we can generate images of metacarpal heads with a resolution as exact as 81 microns voxel size. Two dimensional images were transformed into 3D images, which were visualized by the DICOM viewer Osirix (Open Source software for MacBook). In the following step 3D images were transformed in a printable format called STL (Standard triangulation language), a common file format for 3D printers. Using a ZPrinter (3D Systems/Zcorp), core material (cement-like pouder) was spread in thin layers over the building platform. After each layer, binder is jetted from print heads over the core layer, which causes the core to solidify. <h3>Results</h3> We generated two 3D prints of a metacarpal head, one from a patient (age 67, male) with long standing Rheumatoid Arthritis (RA) and one from a healthy individual of the same age and sex without clinical signs of arthritis. Notably, this approach allowed creating a high quality and exact 3D model of the metacarpal head (Fig. 1A). The printed model reached a resolution as low as 100 micrometers. Cortical bone breaks resembling bone erosions as well as cortical proliferation can be exactly localized and measured. Particularly this technique also allows an enlargement of 3:1 to visualize the trabecular network of the periarticular bone which is massively reduced in the RA patient (Fig. 1B). <h3>Conclusions</h3> Herein we show that it is technically possible to print 3D models of arthritic joints and exactly localize and measure bone erosions and loss of trabecular bone network in patients with inflammatory arthritis. To our knowledge this is the first 3D printing approach in the context of clinical rheumatology. We demonstrate that the production of models reflecting exact copies of the joint surface in brilliant quality is feasible. These findings open multiple new possibilities in rheumatology and management of arthritis such as improved patient education, validation of imaging modalities, monitoring of damage as well as improved site-directed injection <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1856
Identification of the Falciform Artery on Nuclear Medicine Imaging With Successful Coil Embolization for Planned Y-90 Therapy
Authors: Jay Ezra Haggerty, Sandeep Vaidya, Todd Kooy, Satoshi Minoshima, Andrew Shields, Siddharth A. Padia
Journal: Clinical Nuclear Medicine (2011)

The falciform artery (FA) is a branch of the middle or left hepatic artery that runs within the falciform ligament and supplies the periumbilical soft tissue of the abdomen. A 55-year-old man with hepatic carcinoid metastases underwent Yttrium-90 (Y-90) mapping. Tc-99m macroaggregated albumin (MAA) uptake in the anterior abdominal wall, consistent with FA uptake, was identified. At the time of repeat angiography, the FA was detected and coil embolized. Repeat Tc-99m MAA study showed no uptake in the anterior abdominal wall, consistent with appropriate embolization. Tc-99m MAA study confirmed the effectiveness of coil embolization of the FA, facilitating successful Y-90 infusion without complications.
Different Scintigraphic Patterns of Testicular Lesions on Dual-Phase Tl-201 Scan
Authors: SHUNG-SHUNG SUN, FENG-JU CHUANG, CHUN-YI LIN, CHIA-HUNG KAO
Journal: Clinical Nuclear Medicine (2003)

SUN, SHUNG-SHUNG M.D.; CHUANG, FENG-JU M.D.; LIN, CHUN-YI M.D.; KAO, CHIA-HUNG M.D. Author Information
Increased prevalence and severity of radiographic hand osteoarthritis in patients with HIV-1 infection associated with metabolic syndrome: data from the cross-sectional METAFIB-OA study
Authors: Anne-Laurence Tomi, Jérémie Sellam, Karine Lacombe, Soraya Fellahi, Manuela Sebire, Caroline Rey-Jouvin, Anne Miquel, Jean-Philippe Bastard, Emmanuel Maheu, Ida K Haugen, David T Felson, Jacqueline Capeau, Pierre-Marie Girard, Francis Berenbaum, Jean-Luc Meynard
Journal: Annals of the Rheumatic Diseases (2016)

To determine radiographic hand osteoarthritis (HOA) prevalence in patients with HIV-1 infection in comparison with the general population and to address whether metabolic syndrome (MetS) may increase the risk of HOA during HIV-1 infection.Patients with HIV-1 infection and MetS (International Diabetes Federation, IDF criteria) aged 45-65 years were matched by age and gender to HIV-1-infected subjects without MetS and underwent hand radiographs. Framingham OA cohort was used as general population cohort.Radiographic HOA was defined as Kellgren-Lawrence (KL) score ≥2 on more than one joint. Radiographic severity was assessed by global KL score and number of OA joints. HOA prevalence was compared with that found in the Framingham study, stratified by age and sex. Logistic and linear regression models were used to determine the risk factors of HOA in patients with HIV-1 infection.301 patients (88% male, mean age 53.4±5.0 years) were included, 152 with MetS and 149 without it. Overall, HOA prevalence was 55.5% and was higher for those with MetS than those without it (64.5% vs 46.3%, p=0.002). When considering men within each age group, HOA frequency was greater in patients with HIV-1 infection than the general population (all ages: 55.8% vs 38.7%; p<0.0001), due to the subgroup with MetS (64.9%; p<0.0001), as well as the subgroup without MetS, although not significant (46.6%; p=0.09). Risk of HOA was increased with MetS (OR 2.23, 95% 95% CI 1.26% to 3.96%) and age (OR 1.18, 95% CI 1.12 to 1.25). HOA severity was greater for patients with MetS than those without. HOA was not associated with previous or current exposure to protease inhibitors or HIV infection-related markers.HOA frequency is greater in patients with HIV-1 infection, especially those with MetS, than the general population.NCT02353767.
Doctors must explain benefits of reconfiguration to patients, conference hears
Authors: M. Limb
Journal: BMJ (2013)

Doctors must show leadership and speak up publicly in favour of closures of NHS hospital services when the clinical evidence demands it, a conference has heard.

Patients will more readily accept that services need reconfiguring when they hear it from clinicians whose own units will shut, experts said.

David Fish, managing director of University College London (UCL) Partners, an academic health science partnership, urged colleagues to communicate frankly and effectively with the public.

“Leadership,” he said, “is clinicians saying what we could stop doing here [their own workplaces] and do better somewhere else.” He said that doctors should explain how redesigning services across whole systems could help prevent illness and enable earlier diagnosis and should spell out the cost of inaction …
A Correlative Study of Valvular Morphology and Clinical Results in Aortic Commissurotomy
Authors: Robert S. Litwak, Joseph F. Uricchio, William Likoff
Journal: New England Journal of Medicine (1956)

THE surgical treatment of rheumatic aortic stenosis depends upon the ability to split commissural fusion by digital or instrumental means. The initial technic1 required an entrance into the left ventricle through its muscular wall, but more recently the aorta itself has served as the portal to the valve.2 The results of the operation reveal significant clinical improvement in many patients with major manifestations of the lesion.3 , 4 Furthermore, physiologic data in a small series of patients have shown that striking modifications in pressure gradients across the orifice of the valve are attainable.5 These encouraging results are tempered by specific cases in . . .