tbuckley/cabot-search huggingface dataset:
Abstract 4509: Mitochondrial DNA copy number is inversely associated with overall survival in non-small cell lung cancer
Authors: Michelle A. T. Hildebrandt, Xia Pu, Scott M. Lippman, Xifeng Wu
Journal: Cancer Research (2012)

Abstract Mitochondria play an important role in generating energy for vital cellular functions. Alterations in mitochondria function due to mutations or copy number changes can potentially lead to tumorigenesis. Although previous studies have investigated the effect of mitochondrial DNA (mtDNA) depletion on cancer risk, no studies have assessed constitutive mtDNA copy number as a prognostic marker for overall survival in non-small cell lung cancer (NSCLC). Towards this, we measured mtDNA content by a quantitative real-time PCR assay in peripheral blood lymphocytes collected prior to treatment from 1,134 NSCLC cases seen at MD Anderson Cancer Center. A significant inverse dose-response trend was identified for mtDNA content and NSCLC risk (p-value: 0.0076). Those with the highest tertile of mtDNA content had the greatest reduction in risk of dying (HR: 0.81, 95% CI: 0.82-0.97, p-value: 0.014) and a highly significantly enhanced median survival time of 20.20 months compared to only 14.11 months for those with the lowest mtDNA content (p-value: 6.7x10-5). It is known that exposure to tobacco smoke results in the production of reactive oxygen species that can damage mtDNA. Therefore, we also performed stratified analysis based on smoking status. The effect in ever smokers (N=951) mirrored that of the overall population with a significant reduction in risk of death with increasing mtDNA content (p-trend: 0.008) and a dramatic nearly seven month survival advantage for those patients with the highest mtDNA content compared to the lowest (20.73 months compared to 13.98 months, respectively, p-value: 4.1x10-5). Interestingly, mtDNA content was not significant with overall survival in never smokers (N=183), suggesting that the effect in the overall population was driven by the ever smokers and that mtDNA alterations do not play a major role in the course of disease for this unique subgroup of NSCLC patients. Together, these results demonstrate that mtDNA content is a potential prognostic biomarker in NSCLC that can be measured non-invasively prior to treatment to provide needed information regarding course of disease to identify those at high risk for a poor outcome. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4509. doi:1538-7445.AM2012-4509
Characteristics of Overall and Cause-Specific Survival Rates in Breast Cancer Patients under the Age of 40: A Population Based Study of 481,294 Cases in SEER Registry.
Authors: E. Kim, C. Thomas, Jr, C. Hoffelt
Journal: Cancer Research (2009)

Abstract Background: Age at diagnosis has been shown to be an important prognostic factor of outcome for breast cancer (BCA). The specific aim of this study was to determine the overall survival (OS) and cause-specific survival (CSS) in young patients (&amp;lt;40 years old) with BCA relative to older age groups.Methods &amp; Materials: The population of this study comprised of the 481,294 cases of women with BCA extracted from the Surveillance, Epidemiology, and End Results (SEER) registry from 1973-2006, and restaged BCA cases according to AJCC 6th edition staging system. OS and CSS were determined by the Kaplan-Meier method using R. Statistical significance was tested using the log rank or Mantel-Haenszel test in R.Results: The total 481,294 cases were categorized into the following stage groups: Stage 0 (36,692, 7.6%), I (243,460, 50.6%), II (135,013, 28.1%), III (50,233, 10.4%), and IV (15,896, 3.3%). The range of ages was from 11 to 106 (mean 60.5). Ages were divided into 5 groups: &amp;lt;40 (25,918, 5.4%), 40-49 (89,712, 18.6%), 50-59 (116,548, 24.2%), 60-69 (110,536, 23.0%), and &amp;gt;69 (138,580, 28.8%) years old. A graph of OS and tables for OS and CSS from Kaplan-Meier analysis of the entire cohort (all stages) is shown below:OS (all stages) by Age GroupAges \ OS5-year10-year15-year&amp;lt;40.849.764.71440-49.899.830.77550-59.890.810.72560-69.863.728.576≥70.731.479.253 CSS (all stages) by Age GroupAges \ CSS5-year10-year15-year&amp;lt;40.680.785.74240-49.913.859.82550-59.914.864.82560-69.916.860.814≥70.887.820.762 Both OS and CSS of each stage group shared the same trends as in the analysis of the entire cohort.Conclusion: The OS of the &amp;lt;40 year age group was statistically significantly better than the 60's and &amp;gt;69 year age groups, but worse than the 40's and 50's age groups. The CSS of the youngest age group was significantly worse than all age groups except the &amp;gt;69 age group. Further studies to determine contributing variables for these observatios is warranted. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2048.
Case 14-2012
Authors: Bonnie T. Mackool, Jeremy Goverman, Rosalynn M. Nazarian
Journal: New England Journal of Medicine (2012)

A 43-year-old woman with a history of atopic dermatitis was admitted to the hospital because of fever and a generalized painful, pruritic rash involving the entire body. Examination revealed vesicles, pustules, and erosions with scalloped borders. A diagnostic test result was received.
Endoscopic ultrasound-guided tattooing of a retroesophageal parathyroid adenoma
Authors: Silvia Carrara, Luca Cozzaglio, Manol Jovani, Giovanna Pepe, Cristiana Bonifacio, Andrea Anderloni, Alessandro Repici
Journal: Endoscopy (2014)

Primary hyperthyroidism (PHPT) results from an ectopic adenoma located in a retroesophageal space in about 3 % of cases [1]. In these patients, parathyroidectomy is a challenge even for skilled surgeons due to difficulty in identifying the lesion in a very limited operating space between the cervical and thoracic regions. Preoperative imaging techniques include ultrasound, positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI) [2] [3]. Endoscopic ultrasound (EUS) has been proposed as a tool for detecting parathyroid adenomas [4] [5] [6]. This report describes the case of a 74-year-old woman with PHPT.
Decreased Severe Hypoglycemia Frequency During Intraperitoneal Insulin Infusion Using Programmable Implantame Pumps
Authors: Nathalie Jeandidier, Jean-Louis Selam, Eric Renard, Bruno Guerci, Veronique Lassman-Vague, Laure Rocher, Hélène Hanaire-Broutin
Journal: Diabetes Care (1996)
252 INHIBITION OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-α (PPAR-α) REDUCES PROLIFERATION OF PRENEOPLASTIC LIVER FOCI
Authors: M.L. Casella, J.A. Monti, J.P. Parody, M.P. Ceballos, P.I. Ingaramo, D.E. Frances, M.T. Ronco, G.B. Pisani, C.E. Carnovale, M.C. Carrillo, M.L. Alvarez
Journal: Journal of Hepatology (2012)
PWE-155 The Safety Of Ascitic Drain Insertion In Patients With Deranged Coagulation: Abstract PWE-155 Table 1
Authors: SK Sidhu, E Davies, A Turner, K Mcwhirter, A Al-Rifai
Journal: Gut (2014)

<h3>Introduction</h3> Abdominal paracentesis for ascites is not an uncommonly performed procedure. Most patients needing abdominal paracentesis have significant derangement of coagulation. We wanted to assess the safety of abdominal paracentesis in patients with significant INR elevation. <h3>Methods</h3> 67 consecutive patients requiring abdominal paracentesis at our hospital were retrospectively analysed. Patients were placed in to 3 groups depending on the baseline INR (Group A: INR 1–1.4, Group B: INR 1.5–1.9, Group C: INR 1.9 and above). Complication data collected on all patients using a standarised profroma. All data was then entered on to a spreadsheet program (Microsoft Excel) and analysed using SPSS v22. <h3>Results</h3> Of the 67 patients 25 (37%) had a near normal INR (group A), 32 (48%) had moderate INR prolongation and 10 (15%) had significant INR prolongation (group C). 3 patients in group C received fresh frozen plasma (FFP). Overall there was no significant increase in the frequency of Blood staining, Hypotension, Leaking drain site, Infection, Peritonitis, Perforation and Death across all 3 groups (full data and p values shown in Table 1). <h3>Conclusion</h3> The complication rate does not significantly increase with increasingly deranged coagulation. This is despite very low usage of FFP in this study. There is a trend towards an increased risk of bloodstaining and hypotension in the high INR group, which does not achieve statistical significance. <h3>Disclosure of Interest</h3> None Declared.
The control study between endoscopic ultrasonography and pathological diagnosis of upper gastrointestinal mesenchymal tumors
Authors: Cheng Bin, Zhong Li, Wu Xiaoli, Wang Ying
Journal: Endoscopy (2011)

Objective: To observe the pathological and immunohistochemical features of the upper gastrointestinal mesenchymal tumor (GIMTs), and compare its and the EUS sonographic characteristics to evaluate the diagnosis value of EUS in the upper digestive tract GIMTs.
Immediate versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries
Authors: William H. Bickell, Matthew J. Wall, Paul E. Pepe, R. Russell Martin, Victoria F. Ginger, Mary K. Allen, Kenneth L. Mattox
Journal: New England Journal of Medicine (1994)

Fluid resuscitation may be detrimental when given before bleeding is controlled in patients with trauma. The purpose of this study was to determine the effects of delaying fluid resuscitation until the time of operative intervention in hypotensive patients with penetrating injuries to the torso.
Specificity and Sensitivity of Benzyl-Penicillin Skin Testing in Patients with Suspected Hypersensitivity to Penicillin
Authors: Jonathan Lacombe Barrios, Maria Salas, Inmaculada Doña, Francisca Gómez, Leticia Herrero Lifona, Esther Barrionuevo, Maria Isabel Sanchez, Maria Dolores Ruiz, Cristobalina Mayorga, Miguel Blanca, María José Torres
Journal: Journal of Allergy and Clinical Immunology (2015)
FRI0311 Diabetes mellitus as an independent predictor for severe osteoarthritis
Authors: G. Schett, A. Kleyer, M.-A. D’Agostino, C. Perricone, A. Iagnocco, E. Sahinbegovic, F. Berenbaum, J. Zwerina, J. Willeit, S. Kiechl
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Pathogenesis of osteoarthritis may have a strong metabolic component. Thus, alterations in glucose metabolism such as diabetes mellitus may be linked to the development of osteoarthritis. <h3>Objectives</h3> To evaluate if diabetes mellitus is an independent risk factor for severe osteoarthritis. <h3>Methods</h3> Population-based cohort study with a random sample of 927 men and women aged 40 to 80 years followed over 20 years (1990-2010) at the City of Bruneck/Northern Italy. Hazard ratios for arthroplasty were calculated in diabetic and non- diabetic subjects by using age, sex and body mass index-adjusted as well as multivariable models. <h3>Results</h3> Rates of arthroplasty were 17.7 (9.4-30.2)/1000 person-years in diabetic and 5.3 (4.1-6.6)/1000 person-years in non-diabetic subjects (P&lt;0.001). Diabetes was found as an independent predictor of arthroplasty: Hazard ratios (95%CI) for arthroplasty in patients with diabetes mellitus were 3.8 (2.1-6.8; P&lt;0.001) in the unadjusted model and 2.1 (1.1-3.8; P=0.023) in the model adjusted for age, body mass index and other putative risk predictors for OA. Moreover, diabetic patients had more severe symptoms of OA (pain, function and total scores) and ultrasound signs of inflammation (effusion and synovitis; P&lt;0.01 each). <h3>Conclusions</h3> Diabetes mellitus predicts the development of severe OA. This association is independent of age and body mass index, which are the best- established risk factors for OA to date. Our findings strengthen the concept of a strong metabolic component in the pathogenesis of OA and suggest that effective management of OA needs to include the prevention and treatment of diabetes mellitus. <h3>Disclosure of Interest</h3> None Declared
SAT0120 Mediators of Autonomic Neuropathy in Rheumatoid Arthritis
Authors: A. Syngle, I. Verma, P. Krishan, N. Garg
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Cardiovascular autonomic neuropathy (CAN) is a risk predictor for sudden cardiac death in rheumatoid arthritis (RA)<sup>1</sup>. RA is characterized by excess cardiovascular (CV) morbidity and mortality. Elevated interleukin (IL)-1β levels dampen vagal activity<sup>2</sup>, interleukin (IL)-6 influence vagal tone<sup>3</sup> and anti IL-6 and tissue necrosis factor (TNF)-α improve autonomic dysfunction in RA<sup>-5</sup>. Hence we decided to investigate mediators of autonomic neuropathy in RA. <h3>Objectives</h3> To identify predictors of autonomic dysfunction among patients with RA. <h3>Methods</h3> 25 adult patients with RA and 25 age and sex matched healthy controls were enrolled in the study. Autonomic function was assessed by cardiovascular reflex tests according to Ewing and peripheral sympathetic autonomic function was assessed by Sudoscan (Impeto Medical Device, EZS 01750010193 Paris, France). Biochemical estimation of Cytokines (Tumour necrosis factor (TNF)- α, Interleukin (IL)-6 and Interleukin (IL)-1) were measured by ELISA method. Biomarkers of inflammation erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level were also estimated. Disease severity was assessed using the Disease Activity Score in 28 joints (DAS28). <h3>Results</h3> RA patients had significantly impaired heart rate (HR) response to deep breath, HR response to standing, blood pressure (BP) response to hand grip and Sudoscan as compared to healthy controls (all p&lt;0.05). Pro-inflammatory cytokines were significantly higher in RA as compared to healthy controls. TNF-α significantly correlated with HR response to deep breath, standing and Sudomotor function (Fig. 1A), IL-6 significantly correlated with HR response to standing (Fig. 1B), ESR significantly correlated with HR response to deep breath and standing, DAS28 also significantly correlated with HR response to deep breath in RA in univariate analyses. <h3>Conclusions</h3> This study results suggests that autonomic function is impaired in RA. We identified a number of the risk predictors in this study included disease severity, ESR, TNF-α and IL-6. It is likely that the exposure to elevated cytokines associated with enhanced inflammatory state that characterizes RA leads to autonomic neuropathy in this disease. These results can be used to prospectively identify risk of autonomic dysfunction and sudden cardiac death in RA. Treatment with anticytokine drugs especially TNF-α inhibitor and IL-6 blockade could potentially be beneficial for treatment of autonomic dysfunction and its consequences in RA. <h3>References</h3> Milovanovic B et al. Srp Arh Celok Lek. 2010; 138:26-32. Altawil R et al. Ann Rheum Dis. 2012;71 (Suppl 1): A1-A193. Sloan RP et al. Mol Med. 2007; 13:178–184. Syngle A et al. IJRCI. 2013; 1:CS7 Syngle A et al. Acta Reumato Port. 2013; 07-30. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5200
IS THERE ANY ROLE OF MANUAL THROMBECTOMY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION? AN UPDATED META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
Authors: Yasir Akram, Nirmal Kaur, Dahlia Banerji, Aaqib H. Malik, Rishi Bajaj, Shashikanth Nagabandi, Joseph Hannan
Journal: Journal of the American College of Cardiology (2016)
Melanoma vaccines show promise
Authors: D. Josefson
Journal: BMJ (1998)

Two vaccines developed to fight melanoma have shown promise in early clinical trials. The vaccines were used in patients with advanced disease and work by enhancing a patient's immune response to the tumours.

A team led by Dr Steven Rosenberg of the National Cancer Institute in the United States constructed a vaccine based on gp100, a particularly immunogenic protein displayed on the surface of melanoma cells ( Nature Medicine 1998;4:269-70). This was injected into 31 patients with metastatic melanoma who were subsequently treated with interleukin 2, a T …
Republicans Take Over Congress: Research Funding Issues Undecided
Authors: B. Duane
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Republicans Take Over Congress: Research Funding Issues Undecided Get access Betsy Duane Betsy Duane Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 3, February 1995, Pages 170–172, https://doi.org/10.1093/jnci/87.3.170 Published: 01 February 1995
SP0034 Genetics of Scleroderma
Authors: J. Martin
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Systemic sclerosis (SSc or scleroderma) is a multisystem, uncommon disease characterized by fibrosis in skin and internal organs, immune dysregulation, and vasculopathy. Its pathogenesis remains poorly understood, however the disease is thought to arise from an interaction between genetic factors and environmental triggers. Case-control candidate gene genome wide association studies (GWAS) have identified several robust SSc susceptibility loci that have been validated in subsequent independent studies. Some of the confirmed SSc susceptibility loci show a stronger association with its serological or clinical (limited versus diffuse) subtypes than the overall disease. Besides the conformation of HLA genes as the strongest SSc risk loci, these studies have shown that the majority of non-HLA SSc genes such as IRF5, STAT4, CD247, BANK1 or BLK belong to pathways involved in immune regulation, mainly in genes related to innate immunity, as well as B- and T-cell activation, highlighting the important role of an altered immune response in the pathogenesis of Sc. Interestingly, the majority of these gene variants are also risk loci for other autoimmune diseases, especially for systemic lupus erythematosus (SLE). This indicates that SSc has a shared immune pathogenesis with other autoimmune diseases providing further support for the concept of quantitative thresholds in immune-cell signaling. It is noteworthy that the gene variants of interest do not operate in isolation as they are parts of intertwined biological pathways. Therefore, examination of gene-gene or gene-environment interactions can lead to better understanding of SSc pathogenesis. Lastly, mechanistic studies are needed to elucidate how these immune system gene variants contribute to the cross-talk among immune, vascular and fibrotic pathways leading to the unique phenotype of SSc. Beyond identification of new therapeutic targets, the significant advances in SSc genetics represent an opportunity for biomarker development since the genetic information can potentially lead to identification of genetic markers that predict disease severity and response to treatment in SSc. <h3>Disclosure of Interest</h3> None Declared
Abstract 2013: Integrative genomic studies pertaining to cigarette smoke and human lung carcinogenesis
Authors: Maocheng Yang, Sichuan Xi, Fang Liu, Mahadev Rao, David S. Schrump
Journal: Cancer Research (2010)

Abstract Lung cancer is a major cause of cancer deaths worldwide. Whereas the vast majority of these neoplasms are directly attributable to cigarette abuse, the molecular mechanisms contributing to tobacco- associated pulmonary carcinogenesis are not well understood. In the present study, we utilized microarray techniques and systems biology analysis to investigate global mRNA and microRNA (miRNA) expression profiles during lung cancer progression using an in-vitro model. Four sets of cell lines were chosen to examine miRNA/mRNA signatures during lung cancer progression, including primary normal human bronchial epithelia (NHBE) as well as small airway epithelial cells (SAEC), immortalized human bronchial epithelial cells (HBEC), a lung cancer line (H1975) derived from a non-smoker, and three lung cancer lines (H1299, Calu-6 and A549) derived from smokers. Cells were cultured in normal media (NM) with or without cigarette smoke condensate (CSC), the DNA demethylating agent, 5 aza-2’ deoxycytidine (DAC), and the histone deacetylase inhibitor Depsipeptide (DP) to examine how cigarette smoke and epigenetic events may affect global mRNA and miRNA expression during pulmonary carcinogenesis. Based on global mRNA/miRNA expression clustering, primary respiratory epithelial cells, immortalized HBEC, and smoker as well as non-smoker derived lung cancer lines were readily distinguished from one another. Each cell group exhibited its own special set of miRNAs /mRNAs, which were over or under-expressed relative to primary cells. Comparison of miRNA profiles in CSC-treated vs untreated NHBE, SAEC, HBEC, A549 and Calu-6 cells revealed that cigarette smoke induces over-expression of miR-21 and miR-31. MiR-21 and miR-31 were also significantly over-expressed in smoker-derived A549 and Calu-6 lung cancer cells relative to non-smoker-derived H1975. In addition, differential gene expression profiles were observed in smoker-derived vs non-smoker derived lung cancer cells. A group of miRNAs/ mRNA were preferentially modulated by sequential DAC/DP treatment in these cultured cells. Further analysis of differentially expressed miRNAs/mRNAs observed in this model system may provide new insight regarding molecular mechanisms associated with pulmonary carcinogenesis, and reveal novel biomarkers for lung cancer diagnosis and prognosis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2013.
MDP Uptake in Peritoneal Carcinomatosis and Krukenberg Tumors From Mucinous Adenocarcinoma
Authors: Avi G Oppenheimer, Chukwuemeka Onyedika, Leonard M Freeman
Journal: Clinical Nuclear Medicine (2011)

Altered biodistribution of Tc-99m methylene diphosphonate is a common occurrence on bone scintigraphy and mucin-producing neoplasms of the gastrointestinal tract are associated with dystrophic uptake. In addition to the uptake in the primary tumor, activity has been reported in metastasis within lymph nodes and liver. We present a case of Tc-99m methylene diphosphonate uptake in peritoneal carcinomatosis and metastatic Krukenberg tumors from a primary mucinous adenocarcinoma of the descending colon. Each of these findings is uncommon and their combination in this case is particularly unique.