tbuckley/cabot-search huggingface dataset:
SAT0434 Oxidative Stress is Associated to Disease Activity in a Large Cohort of Jia at Transitional Period
Authors: J. Wipff, C. Deslandre, C. Gobeaux, A. Kahan, D. Borderie
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Oxidative damage caused by oxygen free radicals is generally considered a serious mechanism in the pathogenesis of many diseases as cardiovascular diseases, atherosclerosis, and inflammatory rheumatism. Increased oxidative stress has already been described in plasma, saliva and articular fluid of juvenile idiopathic arthritis (JIA) patients. However, most of previous studies did not differentiate ILAR sub-types of JIA and were performed before era of biotherapies. <h3>Objectives</h3> Our aim was to determine characteristics of blood markers of oxidative stress in a large cohort of JIA at transitional period. <h3>Methods</h3> One hundred and ten consecutive JIA, fulfilling ILAR criteria, followed in a transition program were included. Age, sex, disease duration, medical or surgical treatments and remission status were collected. Following laboratory tests were performed: ESR, CRP systematically and antinuclear antibodies, rheumatoid factors and anti-CCP when required for the JIA diagnosis. Oxidative stress parameters were: AOPP (Advanced Oxidation Protein Products) and thiols proteins. Control group consisted of twenty healthy controls without inflammatory condition. <h3>Results</h3> Among the 110 patients' cohort, there were 25 ERA, 16 persistent oligoarthritis, 19 extensive oligoarthritis, 18 polyarticular RF- and 18 RF+ and 14 systemic JIA. Mean age was 21±4 years and mean disease duration was 12.3±3.9 years. Mean global JIA dosage of AOPP was 56.4±47.5µmol/l and thiols proteins was 473.4±41.6µmol/l. No differences were detected when comparing JIA to controls for AOPP and thiols (p=0.4 and p=0.5, respectively). But, AOPP levels in extensive oligoarthritis sub-group was significantly higher than in controls group (82.6±52.9 vs 46.5±6.5, p=0.006). Comparison of oxidative stress parameters according to sub-types of JIA showed that extensive oligoarticular sub-groups was associated with higher degree of oxidative stress i.e. higher levels of AOPP compared to ERA and polyarticular JIA and lower levels of thiols proteins compared to ERA. Thiols proteins levels were strongly associated with disease activity parameters [remission status (p=0.008), number of synovitis (p=0.005), ESR level (p=0.008) and CRP level (p=0.0001)]. <h3>Conclusions</h3> Oxidative stress, in this large cohort of JIA patients at transitional period, is tightly associated with disease activity. This confirms that, in JIA, inflammation could lead to articular and/or profound organs damages by oxidative stress. An absolute tight control of JIA activity seems to be primordial for the future (cardiovascular, atherosclerosis) health of the JIA patients. Our results highlight the potential particularity of extensive oligoarticular sub-type of JIA concerning the oxidative stress. <h3>Disclosure of Interest</h3> None Declared
General Internal Medicine
Authors: Steven A. Schroeder
Journal: JAMA (1986)

Recently, -1- Vecently, internists have embraced decision analysis as a means of more efficient use of diagnostic tests. 1 Members of the internal medicine community have also become increasingly concerned about maintaining the specialty's leadership role in primary care. 2,3 This review, however, will summarize some of the more specific developments in two areas of great importance: prevention of disease and management of chronic illness.  Cigarette smoking remains the single most important cause of preventable morbidity and premature death. Smokers die five to eight years earlier than nonsmokers and have twice the risk of fatal heart disease, ten times the risk of lung cancer, several times the risk of cancers of the mouth, throat, esophagus, pancreas, kidney, bladder, and cervix, a twofold to threefold greater incidence of peptic ulcers (which heal less well in smokers), and about a twofold to fourfold greater risk of fractures of the hip, wrist, and
Abstract 52: Gene expression profiling of breast cancer associated fibroblasts and their adjacent counterparts
Authors: Maha A. Al-Rakan, Dilek Colak, Albandary Al-Bakheet, Namik Kaya, Abdelilah Aboussekhra
Journal: Cancer Research (2012)

Abstract Abstract Breast cancer has a major impact on the health of women worldwide including Saudi Arabia, where it is considered the most frequently diagnosed cancer (∼22% of all female cancers) and the leading cause of cancer deaths among women. Breast carcinomas are complex neoplasms that develop by the accumulation of different mutations in the epithelial cells. However, increasing evidence suggests that changes in the cellular microenvironment contribute to tumorgenesis through paracrine effects. Fibroblasts, the predominant cells of the stromal breast carcinomas, play an important role in the development and spread of cancer cells. However, the nature and the mediators of the crosstalk between cancer cells and their stromal fibroblasts are still not well defined. In this study we performed genome wide expression analysis on 5 Carcinoma-Associated Fibroblasts (CAFs) and their corresponding Tumor Counterpart Fibroblasts (TCFs) (from the same breast cancer patients) as compared to 3 normal breast fibroblasts (NBFs) from breast cancer free patients admitted for plastic surgery. To this end, Affymetix's latest Gene Chip® Human Genome U133 Plus 2.0 Array, which has more than 54,000 probe sets, was used. A threshold of ≤2≥ fold was considered as significant difference in the analysis of the microarray data. We performed 3 different comparisons; CAFs with TCFs, CAFs with NBFs and TCFs with NBFs. The analysis of the microarray data showed that the number of genes that were differentially expressed between CAFs and NBFs reached 101, and only 42 genes were differentially expressed between CAFs and TCFs. Interestingly, 77 genes were found to be differentially expressed between TCFs and NBFs. This data was confirmed by quantitative RT-PCR. Next, we used Ray Bio® Human cytokine Antibody Array 5 Map, which has 80 probed cytokines, and showed differential expression profile of different cytokines secreted by TCF, CAF and NBF cells, confirming that TCFs are different than CAFs and NBFs indicating that TCFs are indeed active stromal fibroblasts. Moreover, we examined the expression level of α-SMA, TGF-β and SDF-1 proteins (3 well known markers of active fibroblasts) and found their expression higher in TCFs than NBFs. In addition, we performed ELISA against SDF-1, VEGFA and IL-6 (3 cytokines known to promote breast carcinogenesis) and found their levels higher in TCFs than in NBFs conditioned media. Therefore, despite the fact that TCFs exist in histologically normal breast tissues, they are not physiologically normal, but rather present some features of active fibroblasts and thereby they may participate in breast cancer development / recurrence. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 52. doi:1538-7445.AM2012-52
How Physicians Handle Drug Investigations
Authors: H. McIntosh
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article How Physicians Handle Drug Investigations Get access Hugh McIntosh Hugh McIntosh Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 18, 18 September 1991, Pages 1282–1284, https://doi.org/10.1093/jnci/83.18.1282 Published: 18 September 1991
TÉCNICA DE DOBLE GUÍA PARA CANULACIÓN DE VÍA BILIAR DIFICULTOSA MEDIANTE ERCP. ¿ES EFICAZ Y SEGURA?. EXPERIENCIA EN UN HOSPITAL DE TERCER NIVEL
Authors: JM Alcívar Vásquez, A Rincón Gatica, R León Montañés, T López Ruíz, S Sobrino Rodríguez, C Martínez Sierra, JM Bozada García
Journal: Endoscopy (2014)

Introducción: La canulación selectiva de la vía biliar es imprescindible en una ERCP, su dificultad es un factor de riesgo en el desarrollo de pancreatitis post-ERCP (PEP); por ello, existen técnicas alternativas que facilitan la canulación biliar, como la técnica de doble guía (DGT).
Evaluated the Diagnostic Utility of Interferon-Gamma Enzyme-Linked Immunospot (ELISPOT) Assays in 117 Patients with Non-Immediate Drug Hypersensitivity Reactions
Authors: Suda Punrin, Pattarawat Thantiworasit, Pungjai Mongkolpathumrat, Jettanong Klaewsongkram
Journal: Journal of Allergy and Clinical Immunology (2016)
INTERACTION BETWEEN MORPHINE AND TICAGRELOR IN THE ATLANTIC STUDY
Authors: Frédéric Lapostolle, Arnoud W. van ‘t Hof, Christian W. Hamm, Jens Flensted Lassen, Olivier Stibbe, Patrick Ecollan, Wim M.J.M Heutz, Muriel Licour, Anne Tsatsaris, Gilles Montalescot
Journal: Journal of the American College of Cardiology (2016)
AB0540 Professional characteristics of patients with spondylarthritis
Authors: I. M. mahmoud, W. B. bousselmi, O. S. saidène, R. T. tekaya, H. S. sahli, L. C. chaabouni, L. A. abdelmoula, R. Z. zouari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Spondylarthritis (Spa) is a chronic inflammatory disease affecting axial skeleton, occurring in young and active patients and often condition their professional prospects. <h3>Objectives</h3> To describe the social and occupational characteristics of patients affected by Spa, to estimate the impact of the disease on their professional activity and to determine factors exposing to elevated risk of premature withdrawal from the labor force. <h3>Methods</h3> We had performed a cross-sectional study of 70 patients with Spa recruited during 4 months at the Department of Rheumatology, felling the criteria of AMOR. Demographic, social and professional characteristics were determinate and some disease-specific instruments: BASDAI, BASFI, BASMI, BASG-s, BASRI, lesquene index were performed <h3>Results</h3> It is about 51 men and 19 women, the average age is 40.61 years. The mean disease duration is 10,75 years. Sixty percent of patients live in urban zone and 17% have an educational level superior to 13 years. The mean score of BASFI is 44.79, the mean score of BASDAI is 45.56, the mean score of BASG-s is 55.64, the mean score of BASMI is of 4.76, the mean score of BASRI is 4,43. Among these patients 82% are eligible to a professional activity (aged between 22 and 65 years and having ended their studies or vocational training). The global unemployment rate is 43%, that's attributed to the disease is 69%. For the specific disease indexes, high risk of withdrawal is positively correlated with pain-VAS(p=0,005), fatigue-VAS(0,021), the BASFI(0,004), the BASG-s(p=0,016), the BASMI(P=0,001), the BASRI(p=0,001) and Lesquene index(p=0,001). the off work during the last three months is positively correlated to the fatigue(p=0,009)and the BASFI(p=0,009). <h3>Conclusions</h3> Several factors are identified to be associated to a high risk of premature working withdrawal in patients affected by Spa. Prevention of this risk needs an early diagnosis and treatment of the disease, a vocational guidance, and work preliminary training. <h3>Disclosure of Interest</h3> None Declared
CLINICAL CHARACTERISTICS AND PROGNOSIS OF VASOSPASTIC ANGINA PATIENTS PRESENTING ABORTED CARDIAC ARREST
Authors: Hye Bin Gwag, Juwon Kim, Suyeon Lee, Kyunghee Lim, Taek Kyu Park, Seung-Hyuk Choi, Jeong Hoon Yang, Young Bin Song, Joo-Yong Hahn, Jin-Ho Choi, Sang Hoon Lee, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2016)
Utility of endoscopic ultrasound to diagnose remnant stones in symptomatic patients after cholecystectomy
Authors: Mehdi Mohamadnejad, Sayed Hashemi, Farhad Zamani, Massoud Baghai-Wadji, Reza Malekzadeh, Mohamad Eloubeidi
Journal: Endoscopy (2014)

<b>Background and study aims:</b> Stones in the cystic duct stump (CDS) or gallbladder remnant after cholecystectomy are difficult to identify. The aim of this study was to evaluate the utility of endoscopic ultrasound (EUS) in the diagnosis of stones in the CDS or gallbladder remnant in patients with postcholecystectomy syndrome. <b>Methods: </b>A prospective study was conducted between January 2011 and December 2012 in consecutive patients with pancreaticobiliary-type pain or acute pancreatitis (n = 112) following cholecystectomy. Diagnostic modalities including EUS were used to diagnose the cause of postcholecystectomy syndrome. <b>Results:</b> A total of 11 patients (10 %) were found to have stones in the gallbladder remnant (n = 8), CDS (n = 2), or both (n = 1). In eight patients, EUS was the first imaging procedure to make the diagnosis. Seven patients agreed to undergo repeat surgery, and six of them remained free of symptoms postoperatively after a median follow-up period of 4 months (range 1 – 13 months). <b>Conclusion:</b> EUS may be an important procedure to consider in the study of patients with symptoms after cholecystectomy, as the diagnosis of residual stones is frequently missed by other imaging modalities.
IDENTIFICATION OF NOVEL CYP2C19 GENETIC VARIANTS IN PATIENTS WITH DEFINITE STENT THROMBOSIS: AN IN-DEPTH SEQUENCING STUDY
Authors: Kashish Goel, Charanjit Rihal, Gregory Jenkins, Saurabh Baheti, Bruce Eckloff, Suzette J. Bielinski, Veronique Roger, Naveen Pereira
Journal: Journal of the American College of Cardiology (2016)
Fractionated Radioimmunotherapy with 90ϒ-Clivatuzumab Tetraxetan in Patients with Metastatic Pancreatic Cancer After ≥ 2 Prior Therapies
Authors: Edith Mitchell, Vincent Picozzi, Ramesh Ramanathan, Paul Conkling, Michael Guarino, Allyson Ocean, Steven Cohen, Nathan Bahary, William Wegener, David Goldenberg
Journal: Annals of Oncology (2013)
Endoscopic removal of a proximally migrated pancreatic stent using a gooseneck snare
Authors: Kazunaga Ishigaki, Tsuyoshi Hamada, Hiroyuki Isayama, Hirofumi Kogure, Yousuke Nakai, Tomonori Wada, Kazuhiko Koike
Journal: Endoscopy (2014)

The effectiveness of pancreatic stents for prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is widely recognized [1]. However, proximal migration of a pancreatic stent is occasionally encountered, potentially necessitating surgical intervention [2] [3]. A gooseneck snare (Amplatz GooseNeck Microsnare Kit; Covidien, Irvine, California, USA), which was originally developed for removing intravascular foreign bodies [4], is a microsnare that forms a 90° angle just after exiting the outer sheath ([Fig. 1]). We herein describe a useful technique for endoscopic removal of a proximally migrated pancreatic stent using this snare.
Midsagittal sections of the cerebellar vermis and fourth ventricle obtained with magnetic resonance imaging of schizophrenic patients
Authors: R J Mathew, C L Partain
Journal: American Journal of Psychiatry (1985)

Measurements of the cerebellar vermis and height of the fourth ventricle made from midsagittal brain images obtained with magnetic resonance imaging did not show any differences between patients with schizophrenia and matched normal control subjects.
AB0790 Clinical characteristics, treatment patterns and disease control among patients with systemic lupus erythematosus receiving steroid-containing standard care regimens in germany, france and spain.
Authors: S. Narayanan, A. Baskett, Y. Lu, R. Hutchings, V. Koscielny
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Corticosteroids (CCS) are a cornerstone of current treatment regimens in Systemic Lupus Erythematosus (SLE). However, increasing evidence points to their significant contribution to medium-to-long term organ damage. <h3>Objectives</h3> To assess the clinical characteristics, treatment patterns and disease control among patients with SLE receiving steroid-containing standard care (SC) regimen in Germany (DE), France (FR) and Spain (SP). <h3>Methods</h3> A multi-center medical chart review study of SLE patients (16-89 yrs) was conducted in August-September 2012 among rheumatologists and internal medicine physicians in hospital and private practices. Physicians were screened for practice length (3-35 yrs) and SLE patient volume (≥15 SLE patients/month) and recruited from a geographically representative sample in each country. Medical charts of eligible patients (approx. 5 per center/practice) with relapse-remitting or persistently active SLE and currently treated as part of usual care were randomly selected. Physicians abstracted de-identified data on diagnosis, disease manifestations &amp; treatment patterns. Physicians reported whether patient’s SLE disease was under control with current treatment (yes/no; per physician-perception). We report data for patients treated with CCS-containing SC regimens. <h3>Results</h3> Analysis included 339 eligible SLE patients (DE:118, FR:125, SP:96); mean age: 40.1yrs, female: 81%; Caucasian: 89%. The most frequent organ systems affected by SLE were: musculoskeletal (86%), mucocutaneous (82%), heamatologic (58%), renal (30%) and pulmonary (17%). Patient disease status/control and treatment patterns are shown in the table. <h3>Conclusions</h3> SLE patients in diverse healthcare settings in 3 European countries had significant residual disease burden during treatment with CCS containing regimens. Majority of patients had moderate/severe disease, and less than one-third were reported to have disease not under control. Differences in CCS dosage appear to exist across the countries studied, with 33% - 58% of the patients on CCS&gt;7.5mg/day despite multi-drug regimens. <h3>Disclosure of Interest</h3> None Declared
Wharton Duct Pseudodiverticulum: An Unusual Cause of Misdiagnosis With Salivary Gland Scintigraphy
Authors: SEYFETTIN ILGAN, KAAN ATAÇ, YÜKSEL PABUŞÇU, HIKMET BAYHAN
Journal: Clinical Nuclear Medicine (1999)

A 22-year-old woman with recurrent swelling and tenderness when eating in the left submandibular region had salivary gland scintigraphy. This showed marked stasis after lemon-juice stimulation of the left submandibular gland. This finding suggested obstruction of the left Wharton duct. Digital subtraction sialography and CT clearly showed that the apparent stasis in the left submandibular region was caused by a giant Wharton duct pseudodiverticulum.
Increased Nuclear Localization of Transcription Factor Y-Box Binding Protein 1 Accompanied by Up-Regulation of P-Glycoprotein in Breast Cancer Pretreated with Paclitaxel.
Authors: T. Fujita, N. Nagura, K. Koshikawa, H. Nishimura, K. Ito, H. Izumi, K. Kohno, M. Fujimori
Journal: Cancer Research (2009)

Abstract Purpose: The Y-box binding protein 1 (YB-1) regulates expression of P-glycoprotein (P-gp) encoded by the MDR1 gene. There have been no previous studies regarding the involvement of YB-1 in the development of resistance to paclitaxel. The present study was performed to examine how paclitaxel affects the localization and expression of YB-1 in breast cancer.Experimental Design: We evaluated the expression and localization of YB-1 and P-gp in breast cancer tissues obtained from 27 patients before and after treatment with paclitaxel. The effect of paclitaxel on localization of cellular YB-1 was examined by using GFP-YB-1. Interaction of YB-1 with the Y-box motif of the MDR1 promoters was studied by EMSA. The effects of paclitaxel on MDR1 promoter activity were examined by luciferase assay.Results: Of 27 breast cancer tissues treated with paclitaxel, nine (33%) showed translocation of YB-1 from the cytoplasm to the nucleus together with increased expression of P-gp during the course of treatment. Twelve breast cancer tissues (44%) showed neither translocation of YB-1 nor increased expression of P-gp. Nuclear translocation of YB-1 was correlated significantly with increased expression of P-gp (P=0.0037). Confocal analysis indicated that paclitaxel induced nuclear translocation of green fluorescent fused YB-1 in MCF7 cells. Furthermore, binding of YB-1 to the Y-box of MDR1 promoter was increased in response to treatment with paclitaxel. In addition, MDR1 promoter activity was significantly up-regulated by paclitaxel in MCF7 cells (p&amp;lt; 0.001).Conclusions: The results of the present study suggested that YB-1 may be involved in the development of resistance to paclitaxel in breast cancer. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 1141.
LONG-TERM RISK OF STROKE IN MYOCARDIAL INFARCTION SURVIVORS: A 30-YEAR POPULATION-BASED NATIONWIDE COHORT STUDY
Authors: Jens Sundboll, Erzsebet Horvath-Puho, Morten Schmidt, Lars Pedersen, Victor Henderson, Hans Erik Botker, Henrik T. Sorensen
Journal: Journal of the American College of Cardiology (2016)
Abstract 679: NDC-1308 nanoparticles inhibit tumor growth by novel mechanisms controlling cancer cell proliferation
Authors: Steven H. Nye, Steven Weitman, James Yarger
Journal: Cancer Research (2011)

Abstract It has previously been demonstrated that treatment of tumor cells with an estrogen receptor beta (ER-β) agonist can lead to cessation of cell division and cell death. We recently reported the discovery of NDC-1308, a member of our estradiol-related family of ER-β agonists, which is cytotoxic to a broad range of human tumor cell lines (EC50 is 5-20 uM). Although NDC-1308 has similar binding affinity for ER-α and ER-β (70-100 nM), functional studies show that it activates ER-β about 5-fold more compared to ER-α. To understand the mechanism of cytotoxicity, A549 (lung), SKOV-3 (ovary), and Panc-1 (pancreatic) human tumor cell lines were treated with NDC-1308 and gene expression changes evaluated by microarray. In all cell lines, NDC-1308 caused a significant down-regulation of key genes critical for chromosome replication, along with the up-regulation of at least two nucleases, granzyme K (GzmK) and apoptosis enhancing nuclease (AEN). There was also a significant up-regulation of pro-apoptotic pathway genes including BBC3 and GDF15 and an up-regulation of a death receptor pathway gene TNFRSF10B (DR5). These results suggest that ER-β activation by NDC-1308 may be useful to trigger DNA damage, cell cycle arrest and ultimately the death of cancer cells. However, PK studies in rodents showed that NDC-1308 has a short half-life, thereby lowering its potential efficacy as a cancer therapeutic. In order to optimize the blood circulation time and to enhance the accumulation of NDC-1308 in tumors, the drug was formulated into several different types of nanoparticles (50-100 nm), including an amorphous drug particle, a lipid-containing particle and a micelle-based particle. Whole body imaging studies showed that NDC-1308 nanoparticles conjugated with AlexaFluor 750 could localize to human tumors such as colon adenocarcinomas, renal cell carcinomas and lung adenocarcinomas in nude mice (N=4 per tumor type). To determine the efficacy of NDC-1308 as an anti-cancer therapy, nude mice bearing A549 human tumors (N=12 per group) were dosed every other day with NDC-1308 nanoparticles (up to 24 mg/kg of the active drug) via tail vein injection. During treatment, this led to a significant, dose-dependent reduction in tumor size in drug treated animals versus untreated controls. We conclude that intravenous administration of NDC-1308 nanoparticles can inhibit the rate of human tumor growth in a mouse model of cancer. Our future development plans include large animal safety and toxicity studies, followed by IND submission and Phase 1 clinical trials. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 679. doi:10.1158/1538-7445.AM2011-679