tbuckley/cabot-search huggingface dataset:
Abstract 1793: Platelet-derived growth factor receptor alpha blockade significantly enhances sensitization to docetaxel in ovarian carcinoma
Authors: Koji Matsuo, Rebecca L. Stone, Mian Shahzad, Amy R. Carroll, Hee-Dong Han, Sun-Joo Lee, Masato Nishimura, Edna Mora, Chunhua Lu, Nick Loizos, Anil K. Sood
Journal: Cancer Research (2010)

Abstract Objective: Platelet-derived growth factor receptor alpha (PDGFRα) is a member of class III receptor tyrosine kinase and is associated with cell survival. Here, we examined whether PDGFRα blockade enhances the anti-tumor activity of taxanes in ovarian carcinoma. Methods: PDGFRα expression was evaluated with RT-PCR and Western blot in multiple ovarian cancer cell lines. Human-specific monoclonal antibody to PDGFRα (IMC-3G3, ImClone Systems, NJ, USA) was used for in-vitro (cell viability assay, apoptosis assay) and in-vivo experiments with or without docetaxel. Results: All eleven tested ovarian cancer cell lines had variable expression of PDGFRα. OVCA433 cell line had the highest level of expression of PDGFRα. IMC-3G3 blocked PDGFRα phosphorylation in response to PDGF-AA stimulation. IMC-3G3 alone had no affect on cell viability in all tested cell lines. However, IMC-3G3 significantly enhanced sensitization to docetaxel: IC50 reduction rate, SKOV3-ip1, 25.5%; HeyA8-parental, 31.7%; OVCA433, 35.3%; and HeyA8-MDR, 44.2% (all, p&amp;lt;0.05). While treatment with IMC-3G3 alone did not increase apoptosis, concurrent use with docetaxel significantly enhanced docetaxel-mediated apoptosis (mean percentage of total apoptotic cells in SKOV3-ip1, untreated vs IMC-3G3 alone vs docetaxel alone vs docetaxel with IMC-3G3, 7.3% vs 7.1% vs 15.4% vs 22.2%, p&amp;lt;0.001). In the in-vivo experiment with SKOV3-ip1 bearing mice, administration of IMC-3G3 monotherapy had no significant anti-tumor effects compared to the control group (mean tumor weight, 2.5 ± 0.32 vs 2.9 ± 0.51 grams, p&amp;gt;0.05). Concurrent use of IMC-3G3 with docetaxel significantly reduced tumor weight compared to docetaxel alone (mean tumor weight, 0.22 ± 0.07 vs 0.63 ± 0.14 grams, tumor reduction rate 65.1%, p&amp;lt;0.05). Conclusion: IMC-3G3 significantly enhances the anti-tumor effects of docetaxel. Therefore, targeting PDGFRα may be an attractive approach for increasing the cytotoxic effects of chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1793.
Abstract 3468: MMP-9 inhibition abolishes hypoxia-induced angiogenesis in medulloblastoma
Authors: Chandramu Chetty, Praveen Bhoopathi, Jasti S. Rao, Sajani S. Lakka
Journal: Cancer Research (2011)

Abstract Hypoxia-inducible factor-1 (HIF-1) transcription factor is a critical mediator of the hypoxic response and upregulates expression of various proteins that promote angiogenesis and many other survival pathways in cancer. Overexpression of HIF-1α and matrix metalloproteinase-9 (MMP-9) is common in human cancers, including medulloblastoma, and is correlated with a malignant phenotype. Therefore, we investigated the effects of hypoxia-induced MMP-9 on angiogenesis in medulloblastoma cells. Western blotting and immunohistochemical analysis showed that hypoxia enhanced stabilization of HIF-1α and expression of VEGF and MMP-9 in medulloblastoma cells in vivo and in vitro. Further, endothelial tube formation assay in vitro and dorsal air sac assay in vivo showed that hypoxia enhanced angiogenesis in medulloblastoma cells. Transcriptional inactivation of MMP-9 using siRNA (pMMP-9-Si) inhibited hypoxia-induced stabilization of HIF-1α, and induced expression of VEGF and prolyl hydroxylase. Moreover, supplementation of human recombinant MMP-9 in MMP-9-Si-transfected cells restored VEGF expression and angiogenesis. In summary, the results of the present study indicate that MMP-9 upregulation could be an important mediator of tumor hypoxia-induced angiogenesis. Therefore, inhibition of MMP-9 could be an effective therapeutic strategy for the treatment of hypoxic medulloblastoma cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3468. doi:10.1158/1538-7445.AM2011-3468
AB0438 Clinical features of pneumocystis pneumonia in patients with rheumatoid arthritis, in comparison with pneumocystis pneumonia in acquired immunodeficiency syndrome
Authors: T. Nunokawa, K. Ohashi, S. Sugii, K. Shimada, N. Yokogawa
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Pneumocystis pneumonia (PCP) is rare, but life-threatening complications in patients with rheumatoid arthritis (RA). PCP in RA exhibits differently from PCP in acquired immunodeficiency syndrome (AIDS). <h3>Objectives</h3> The aim of this study is to reveal clinical and laboratory differences between PCP in patients with RA and PCP in AIDS. <h3>Methods</h3> We reviewed electric chart of our hospital from 1/2006 to 12/2011. PCP was difined by the following criteria a) symptoms and radiological findings compatible with PCP b) detection of <i>P. jirovecii</i> by polymerase chain reaction (PCR) in respiratory specimens, c) elevated plasma (1$→ $3)-β-D-glucan level. We compared the clinical features between RA patients and AIDS patients. <h3>Results</h3> Forty-one patients were diagnosed with PCP: 15 with RA, 10 with AIDS, 8 with connective tissue disease (CTD), 3 with cancer, 5 with others. In RA patients, 6 patients were on biologic therapy with or without low dose prednisolone. Seven patients were treated with low dose prednisolone and non-biologic DMARDs: 5 on methotrexate, 2 on methotrexate and tacrolimus, and 2 on steroids alone. Positivity of Grocott stain in RA patients was significantly lower than that in AIDS patients (7.1% vs 77.8%, <i>p</i>=0.0005). Serum LDH and CRP in RA patients were significantly higher than those in AIDS patients (<i>p</i>=0.04 and <i>p</i>=0.004, respectively). Three in RA patients died while none in AIDS patients. <h3>Conclusions</h3> In RA patients, low dose steroids or DMARDs can induce PCP and PCR method should be used to detect <i>P. jirovecii</i>. We speculate PCP in RA patients may have more intense inflammation with less parasite burden and, as a result, worse prognosis than PCP in AIDS patients <h3>Disclosure of Interest</h3> None Declared
Angiotensin Receptors and Their Antagonists
Authors: Theodore L. Goodfriend, Mary E. Elliott, Kevin J. Catt
Journal: New England Journal of Medicine (1996)

Angiotensins are peptide hormones derived from the protein precursor angiotensinogen by the sequential actions of proteolytic enzymes (Figure 1). The classic pathway of angiotensin synthesis includes a reaction catalyzed by angiotensin-converting enzyme (ACE), which occurs not only in plasma but also in the kidneys, brain, adrenal glands, ovaries, and possibly other tissues.1 The intrarenal renin–angiotensin system affects glomerular filtration, as discussed below, but the importance of angiotensin synthesis in other tissues is not known. Angiotensin II, the principal effector of the renin–angiotensin cascade, can also be synthesized by a pathway that does not require ACE.2 Angiotensin II stimulates a variety . . .
Breast Cancer Clinicoal Alert--The Public's Reaction
Authors: C. D. Hallet
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Breast Cancer Clinicoal Alert—The Public's Reaction Get access Cynthia D. Hallet Cynthia D. Hallet Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 14, 19 July 1989, Pages 1057–1058, https://doi.org/10.1093/jnci/81.14.1057 Published: 19 July 1989
Dendritic Cells and Macrophages in Lung Allografts
Authors: COLM T. LEONARD, PAOLA M. SOCCAL, LIANNE SINGER, GERALD J. BERRY, JAMES THEODORE, PATRICK G. HOLT, RAMONA L. DOYLE, GLENN D. ROSEN
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Antigen presentation by lung macrophages/dendritic cells (DC) is thought to be important in obliterative bronchiolitis/bronchiolitis obliterans syndrome (OB/BOS), which severely limits survival post-lung transplantation. However, a recent study found minimal numbers of DC in lung allografts. We looked at numbers and phenotype of macrophages/DC in lung allografts using endobronchial biopsy (EBB) and transbronchial biopsy (TBB) from 22 lung transplant patients. Biopsies were stained with monoclonal markers of DC (CD1a, RFD1, and major histocompatibility complex [MHC] Class II), and "suppressor macrophages" (RFD1 and RFD7). Dendritic cells were also stained for the costimulatory molecules CD80 and CD86. Significantly greater numbers of DC/high-power field (HPF) were seen in biopsies when we defined DC using dendritic morphology and Class II MHC expression instead of CD1a expression. Dendritic cell numbers were significantly higher in eight patients with OB/BOS compared with 14 stable patients. Fifty percent of DC expressed CD86 and 20% expressed CD80. There was no difference in CD80 or CD86 expression between OB/BOS patients and stable patients. There was no correlation between DC numbers and presence or absence of acute rejection (AR), and/or cytomegalovirus (CMV) pneumonitis on current or prior biopsies. There were significantly more MHC Class II DC in EBB compared with TBB. We found minimal staining for lung macrophages capable of suppressing T-cell inflammation. We conclude that studies of lung allografts may underestimate DC numbers if relying on CD1a as the sole marker of DC. DC are increased in patients with OB/BOS compared with stable patients. EBB may be more important than TBB in looking for inflammatory changes of OB. DC expressing costimulatory molecules are present in lung allografts, and costimulatory pathway blockade may be useful in human lung allografts. Also, the absence of "suppressor" macrophages may increase susceptibility of human lung allografts to the rejection process.
SP0110 Nanomedicine-Innovate Drug Delivery
Authors: D. J. Brayden
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Inflammatory responses contribute to the pathogenesis of rheumatoid arthritis and to aspects of osteoarthritis (OA). We used the K/BxN mouse model of acute joint inflammation and cartilage breakdown to assess whether intra-articular (i.a.) administration of two agents in a nanoparticle construct might in part resolve joint specific inflammation. Firstly, we discovered that salmon calcitonin (sCT) could down-regulate RNA expression of the orphan nuclear receptor, NR4A2, which is a key regulator and potential biomarker for inflammation and represents a potentially valuable therapeutic target. This was surprising as sCT is marketed as only a second line anti-osteoporotic drug and the basis of its anti-inflammatory effects is poorly understood. sCT attenuated activated mRNA expression of NR4A1, NR4A2, NR4A3, and matrix metalloproteinases 1, 3 and 13 in human cell lines: SW1353 chondrocytes as well as U937 and THP-1 monocytes. Hyaluronic acid, a recognised approved intra-articular agent used for OA by i.a. injection, also surprisingly reduced expression of NR4As and MMPs in activated cells. sCT and HA were then mixed and further down-regulated expression of NR4A2 compared to either agent alone at specific concentrations, hence the rationale for their formulation in electrostatic-based nanocomplexes (NP) using chitosan or protamine. In vitro release studies showed that the sCT released gradually over 5 days and the released peptide stimulated cAMP production in human T47D breast cancer cells expressing sCT receptors. NP containing sCT and HA were then injected by the i.a. route to the mouse knee during on-going inflammatory arthritis of the K/BxN serum transfer model and data was compared to a positive steroid control. Joint inflammation diameter was reduced together with NR4A2 expression, and local bone architecture was preserved by the NP on a par with dexamethasone. The data suggests that it might be possible to reduce the dose of steroid or replace steroids with nanoparticulate-based drug combinations for i.a. treatments of OA. Initial studies in a more established chronic model of inflammation, the collagen-induced mouse however, have been problematic as the model has high variability and in our hands thus far, responds to intra-peritoneal- but not i.a.-administered steroids or other treatments. <h3>Disclosure of Interest</h3> None Declared
Corrosive (Acid) Gastritis
Authors: Frederick Steigmann, Robert A. Dolehide
Journal: New England Journal of Medicine (1956)

THE American literature contains comparatively few reports of cases of corrosive gastritis, of either the acute or the chronic variety. Because few patients survive the initial insult for more than twenty-four hours, the concept of the management of such cases is somewhat nebulous. Some of the reports in the literature deal primarily with the late sequelae of corrosive poisoning. Very few patients have survived the initial insult long enough to be followed under medical supervision until the late sequelae of pyloric obstruction appeared. Some steps in the management of such cases have been referred to in a previous publication by . . .
SPECT in the Early Diagnosis of Creutzfeldt-Jakob Disease
Authors: G Frazzitta, G Grampa, I La Spina, F Reverberi, L Pedrazzini, D Uccellini, A Vignati, D Porazzi
Journal: Clinical Nuclear Medicine (1998)

Changes in brain imaging of regional cerebral blood flow with SPECT using TC-99m HMPAO were observed in a 68-year-old woman with Creutzfeldt-Jakob disease (CJD). Focal hypoperfusion in the left fronto-parieto-temporal regions, corresponding to the periodic synchronous discharges localized in the left frontal region on EEG, were detected on SPECT imaging before CT and MRI showed any abnormalities. These findings suggest that brain SPECT may be more useful in the early detection of site-specific abnormalities in CJD.
Chest X-ray Artifact Caused by Bilateral 99mTc-Antimony Trisulfite Injection for Sentinel Node Imaging in a Patient With Breast Cancer
Authors: William Makis, Don Robinson, Alexander J.B. McEwan, Terence A. Riauka
Journal: Clinical Nuclear Medicine (2015)

A 52-year-old woman diagnosed with invasive ductal carcinoma of both breasts had a chest x-ray for preoperative assessment. A striking artifact was noted by the x-ray technologist, who, as a result, became very concerned about radiation exposure from the patient. The patient had undergone bilateral sentinel lymph node injections in the nuclear medicine department with 99mTc-antimony trisulfite colloid just 2 hours before the chest x-ray. Radiation exposure to the x-ray technologist was determined to be similar to 8 hours of naturally occurring background radiation (∼2.96 μSv).
BNCT: Looking for A Few Good Molecules
Authors: N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article BNCT: Looking for A Few Good Molecules Get access Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 9, 6 May 1992, Pages 670–671, https://doi.org/10.1093/jnci/84.9.670 Published: 06 May 1992
EUS guided drainage of pseudocyst lacking luminal bulge or having collaterals; tapered catheter vs. 6Fr cystostome for “initial track dilation” – a randomized controlled trial
Authors: S Lakhtakia, R Gupta, A Nagar, N Pratap, M Ramchandani, D Santosh, GV Rao, DN Reddy
Journal: Endoscopy (2011)

Introduction: Endoscopic drainage of pseudocyst carries a risk, especially in pseudocyst having vessels in the wall or lacking a prominent luminal bulge. Endoscopic Ultrasound (EUS) guided drainage of such pseudocyst has become the standard of care.
Role of endoscopic ultrasound for the selection of candidates to receive neodjuvant therapy in patients with gastric adenocarcinoma
Authors: A Vilella, A Brotons, J Di Giorgio, C Dolz
Journal: Endoscopy (2011)

For the administration of the new neodjuvant chemotherapies in patients with locally advanced gastric adenocarcinoma, is necessary to make a correct and precise staging in order to decide the therapeutic approach to these patients.
Abstract 1246: Mechanism of endostatin action in prostate cancer in dependent on androgen receptor signaling
Authors: Tatyana Isayeva, Diptiman Chanda, George Tsuladze, Lakisha Moore, Selvarangan Ponnazhagan
Journal: Cancer Research (2010)

Abstract We recently reported that stable expression of endostatin and angiostatin arrested the progression of well differentiated prostate carcinoma to poorly-differentiated state and distant metastasis in TRAMP mice when given prior to the onset of metastasis switch. Analysis of the expression of angiogenesis-related genes in the prostate tissue of endostatin treated mice indicated a significant downregulation of genes involved in cell motility, proliferation, metastasis and angiogenesis when therapy was initiated at early stage-disease. In vitro experiments demonstrated that recombinant endostatin treatment significantly downregulated the expression of growth factors, receptor tyrosine kinases and proteases in androgen sensitive cells. A similar pattern was confirmed in prostate tissues obtained from in vivo studies. Targeted downregulation of androgen receptor (AR) prior to endostatin treatment indicated that the effect of endostatin through AR downregulation is by a non-genotypic mechanism on MAPK/ERK pathway, and independently of Src kinase. Further analysis indicated the kinetics of endostatin internalization for androgen sensitive prostate cancer cells to be much higher than in androgen independent cells. Co-immunoprecipitation studies in human prostate cancer cells, and yeast two-hybrid studies with endostatin and AR demonstrated a direct binding of endostatin protein with AR. Based on the results so far, we predict that direct interaction of endostatin with AR possibly eliminates ligand binding during early stages of prostate cancer arresting and delaying the progression of the disease. However, once metastatic switch occurs, when the cells grow in androgen independent manner, a limitation in endostatin internalization or binding of non-androgen ligands at other domains in AR impairs the tumoristatic ability of endostatin. Ongoing studies are aimed in identifying interaction domains of endostatin with AR by NMR as well as testing the combination of endostatin therapy with therapies targeting AR signaling. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1246.
Detection of a Recurrent Parathyroid Carcinoma with FDG Positron Emission Tomography
Authors: NURI ARSLAN, BART RYDZEWSKI
Journal: Clinical Nuclear Medicine (2002)

From the Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri Received for publication August 14, 2001. Accepted September 26, 2001. Reprint requests: Nuri Arslan, Department of Nuclear Medicine, Gulhane Military Medical Academy and Medical Faculty, Etlik, Ankara, Turkey, 06018. Email: [email protected]
CARDIAC MYOSIN BINDING PROTEIN C IS A NOVEL CIRCULATING MARKER OF MYOCARDIAL INJURY AND FIBROSIS IN PATIENTS WITH AORTIC STENOSIS
Authors: Atul Anand, Calvin Chin, Anoop Shah, Jacek Kwieciński, Alex Vesey, Marc Dweck, Joanna Cowell, Thomas Kaier, David Newby, Michael Marber, Nicholas Mills
Journal: Journal of the American College of Cardiology (2016)
68Ga-DOTA-NOC PET/CT Detects Somatostatin Receptors Expression in von Hippel-Lindau Cerebellar Disease
Authors: Valentina Ambrosini, Davide Campana, Vincenzo Allegri, Giuseppe Opocher, Stefano Fanti
Journal: Clinical Nuclear Medicine (2010)

A case of Von-Hippel Lindau (VHL) disease has been studied using 68Ga-DOTA-NOC PET/CT. PET/CT demonstrated the presence of somatostatin receptors within 2 focal areas in the cerebellum corresponding to the lesions detected by MRI. Considering the heterogeneous lesions localizations in VHL disease, PET/CT may be a useful imaging modality for diagnosing lesions of central nervous system and neuroendocrine lesions and for direct demonstration of somatostatin receptors for targeted treatment.
Intra-operative specimen sonography: a valuable tool to identify tumor free margins during breast-conserving therapy.
Authors: V Zarghooni, A Hübbel, C Moers, R Würstlein, P Mallmann, M Warm
Journal: Cancer Research (2009)

Abstract Abstract #4146 Background:&amp;#x2028; Today, breast conserving therapy (BCT) represents the standard of care for the majority of patients with breast cancer. One significant technical difficulty remaining for the surgeon is the intraoperative estimation of tumor size in the attempt to achieve clear margins. We hypothesized that the use of intraoperative ultrasound evaluation of specimen would increase the rate of microscopically clear margins during lumpectomy.&amp;#x2028; Methods:&amp;#x2028; All patients who underwent lumpectomy for breast cancer at our hospital during 2007 were eligible. The study was non-randomized with retrospective data acquisition. In cases with positive ultrasound margins, the surgeon was guided to achieve disease- free margins. All cases with intraoperative specimen ultrasound were compared to cases without specimen sonography. We evaluated the technique of intraoperative sonography, the rate of tumor free margins, and the rate of re-excisions.&amp;#x2028; Results:&amp;#x2028; Of the 252 patients, 78 patients (31%) were evaluated with intraoperative specimen sonography. Operation times did not show significant differences in both groups.&amp;#x2028; In the group with intraoperative specimen sonography the rate of microscopically free margins was 96%, compared to 81% in the control group. Intraoperative specimen sonography proved to be a useful adjunct in this series of patients because it significantly reduced the rate of re-excisions.&amp;#x2028; Conclusion:&amp;#x2028; Intraoperative specimen sonography proved to be a reliable and helpful tool for detection of tumor free margins in lumpectomy for breast cancer. It significantly reduces the rate of re-excions during breast conserving therapy. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 4146.
Abstract 4968: Phosphorylation of caspase-8 (Thr263) by ribosomal S6 kinase 2 (RSK2) mediates caspase-8 ubiquitination and stability
Authors: Cong Peng, Yong-Yeon Cho, Feng Zhu, Haitao Li, Xiang Li, Hua Xie, Ann M. Bode, Zigang Dong
Journal: Cancer Research (2012)

Abstract The ribosomal S6 kinase 2 (RSK2) is a member of the p90 ribosomal S6 kinase (p90RSK) family of proteins and plays a critical role in proliferation, cell cycle and transformation. Here, we report that RSK2 phosphorylates caspase-8 and Thr263 was identified as a novel caspase-8 phosphorylation site. Phosphorylation of Thr263 is associated with the ubiquitination and degradation of caspase through the proteasome pathway. Results suggested that RSK2 regulates caspase-8 stability through its phosphorylation of this caspase. These data provide a direct link between RSK2 and caspase-8 and identify a novel molecular mechanism for caspase-8 modulation by RSK2. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4968. doi:1538-7445.AM2012-4968