tbuckley/cabot-search huggingface dataset:
Effect on patient outcome of residual DCIS in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy
Authors: C. Mazouni, F. Peintinger, S. Wan-Kau, F. Andre, A. M. Gonzalez-Angulo, F. Symmans, F. Meric-Bernstam, V. Valero, G. Hortobagyi, L. Pusztai
Journal: Journal of Clinical Oncology (2007)

530 Background: To determine whether residual ductal carcinoma in situ (DCIS) after completion of preoperative chemotherapy affects the outcome of patients with hiostologically defined complete eradication of invasive cancer. Methods: Retrospective analysis of a database including 2,302 breast cancer patients treated prospectively with neoadjuvant chemotherapy at the UT MD Anderson Cancer Center between 1980 and 2004 was performed. The overall, disease-free and local recurrence-free survivals were compared for patients with no residual invasive or in situ cancer (pCR) and those with no residual invasive cancer but persistent in situ disease (pCR+DCIS). Results: The mean follow-up was 250 months. Of the 2,302 treated patients 78 (3.4%) had pCR, 199 (8.6%) had pCR+DCIS, and 2025 (88%) had residual invasive cancer. The 5-year (87.1% in both) and 10-year (81.3% vs 81.7%) disease-free survival rates were similar for cases with pCR and pCR+DCIS. The 5-year (91.9% vs. 92.5%) and 10-year (91.8% vs. 92.5%) overall survival rates were also similar and significantly better than the rate of patients with residual invasive cancer (74.4%, p&lt;0.001). The 5-year local-regional recurrence-free survival rates were also not different for patients with pCR (92.8%, 95% CI: 86.1%-96.4%) and those with pCR+DCIS (90.9%, 95% CI: 77.3%- 96.5%), p=0.63. Conclusions: Residual DCIS in patients who experience complete eradication of the invasive cancer in the breast and lymph nodes does not adversely affect survival or local recurrence rate. Inclusion of cases with residual DCIS in the definition of pathologic complete response is justified when this outcome is used as early surrogate for long term-survival. No significant financial relationships to disclose.
The Work of a Physical-Fitness Clinic
Authors: William R. P. Emerson
Journal: New England Journal of Medicine (1948)

THIS is a report of a physical-fitness clinic conducted at the Massachusetts headquarters of the Blue Cross among approximately 900 executives and employees.The personnel conducting the clinic consisted of one experienced physical-fitness worker; three physicians, part time, especially trained to make physical examinations to detect not only disease but also any physical defects that might cause impaired health; and a secretary trained in statistics, to tabulate results and to act as receptionist and make appointments. I supervised the work and saw problem cases one morning each week.The physical-fitness worker and the secretary were on full time. One of . . .
Effects of Cigarette Smoking on Lung Function in Adolescent Boys and Girls
Authors: Diane R. Gold, Xiaobin Wang, David Wypij, Frank E. Speizer, James H. Ware, Douglas W. Dockery
Journal: New England Journal of Medicine (1996)

Little is known about the sex-specific effects of cigarette smoking on the level and growth of lung function in adolescence, when 71 percent of people in the United States who smoke tried their first cigarette.
Eradication of CD44-variant positive population in head and neck tumors through controlled intracellular navigation of cisplatin-loaded nanomedicines
Authors: Ming Wang, Yutaka Miura, Kenji Tsuchihashi, Kazuki Miyano, Osamu Nagano, Momoko Yoshikawa, Ami Tanabe, Jun Makino, Yuki Mochida, Nobuhiro Nishiyama, Hideyuki Saya, Horacio Cabral, Kazunori Kataoka
Journal: Journal of Controlled Release (2016)
PT-07 * PINEALOBLASTOMAS
Authors: R. Kebudi, B. Koc, F. Y. Agaoglu, O. Gorgun, J. Wolff, S. B. Kapu, A. Kebudi, F. B. Cak r, E. Darendeliler
Journal: Neuro-Oncology (2014)

OBJECTIVES: Pinealoblastomas (PBL) are rare tumors of the central nervous system and more common in children. The objective of this study is to evaluate the demographic data and outcome of children with PBL in a single center. METHODS: Files of children diagnosed with pinealoblastoma in the Istanbul University, Oncology Institute were evaluated retrospectively for demographic data, treatment and long term outcome. RESULTS: During 1990-2012, 6 children (3 male, 3 female) with a median age of 6 years (2 years- 14 years), were diagnosed with pinealoblastoma, in the Istanbul University, Oncology Institute. At the same time interval 494 patients <19 years old were diagnosed with malignant central nervous system (CNS) tumors in the same center, thus pinealoblastomas constituted 1. 2 % of all CNS tumors. Three had subotal resection and three underwent a biopsy. At diagnosis, one had spinal seeding both in MRI and cerebrospinal fluid cytology. All received craniospinal radiotherapy and chemotherapy, the patient < 3 years old received neoadjuvant chemotherapy first. The median follow up is 5 years (1-9.5 years). Two patients are alive for 5.5 and 10 years. One has just had a total thyroidectomy for papillary thyroid cancer as a second malignancy at 9.5 years. All others have died at a median of 2.7 years due to progressive disease. CONCLUSIONS: In conclusion, PBL are aggressive tumors necessitating intensive treatment strategies including surgery, craniospinal radiotherapy and chemotherapy. Patients should be followed up for long term side effects such as second malignancies.
The Effectiveness of Vaccination against Influenza in Healthy, Working Adults
Authors: Kristin L. Nichol, April Lind, Karen L. Margolis, Maureen Murdoch, Rodney McFadden, Meri Hauge, Sanne Magnan, Mari Drake
Journal: New England Journal of Medicine (1995)

Although influenza causes substantial morbidity and mortality in all age groups, current recommendations emphasize annual immunization for people at high risk for complications of influenza. We conducted a double-blind, placebo-controlled trial of vaccination against influenza in healthy, working adults.
P393miR-1: a link between SERCA2a and the Beta-Adrenoceptor in the failing heart?
Authors: A M Mills, MB Sikkel, R Kumarswamy, KT Macleod, AR Lyon, T Thum, SE Harding
Journal: Cardiovascular Research (2014)

Purpose: Changes to the cellular expression of numerous microRNAs (miRs) have been implicated in disease development. MiR-1 expression is down-regulated in human heart failure (HF) and our in vivo rat HF model, we aimed to further understand its significance in HF. We previously showed that miR-1 expression was restored by in vitro adenovirus-mediated restoration of SERCA2a in adult rat HF cardiomyocytes, in response to diastolic calcium changes.
IMPACT OF LEFT VENTRICULAR OUTFLOW TRACT OBSTRUCTION AND MICROCIRCULATORY DYSFUNCTION ON CORONARY HAEMODYNAMICS IN HYPERTROPHIC CARDIOMYOPATHY
Authors: Claire E. Raphael, Robert Cooper, Jennifer Keegan, Ricardo Wage, Sukhjinder Nijjer, Christopher Broyd, Vass Vassiliou, Aamir Ali, Julian Collinson, Ranil de Silva, Michael Paul Frenneaux, Rod Stables, Carlo Di Mario, Dudley Pennell, Darrel Francis, Justin Davies, Kim H. Parker, Sanjay Prasad
Journal: Journal of the American College of Cardiology (2015)
TCT-654 Comparison in the 5-year Outcome of Pericardium and Polytetrafluoroethylene-Covered Stents for Saphenous Vein Graft Lesions
Authors: Sandeep Basavarajaiah, Massimo Slavich, Ahmed Rezq, Tasuku Hasegawa, kensuke Takagi, Toru Naganuma, Chiara Bernelli, Azeem Latib, Mauro Carlino, Alaide Chieffo, Matteo Montorfano, Cosmo Godino, Antonio Colombo
Journal: Journal of the American College of Cardiology (2012)
Migrated surgical clip-induced choledocholithiasis
Authors: J. Molina-Infante, M. Fernandez-Bermejo, J. Mateos-Rodriguez
Journal: Endoscopy (2011)

An 88-year-old woman with a history of open cholecystectomy for symptomatic gallstones 12 years previously was admitted due to colicky right upper quadrant pain and obstructive jaundice. Abdominal ultrasonography showed extrahepatic bile duct dilatation (12 mm) and choledocholithiasis in the distal common bile duct (CBD). At endoscopic retrograde cholangiopancreatography (ERCP) before contrast injection, she was noted to have a mobile, metal foreign body inside the distal CBD ([Fig. 1 a, b]), in addition to the cholecystectomy clip that was seen at the cystic duct. Cholangiogram revealed that this foreign body was located in the center of a 10-mm oval-shaped defect that was suggestive of choledocholithiasis ([Fig. 1 c]).
FRI0274 Decrease in lumbar spine bone mineral density in patients with early axial spondyloarthritis is highly associated with spinal inflammation on MRI: Results from the DESIR cohort
Authors: K. Briot, A. Durnez, S. Paternotte, C. Miceli-Richard, M. Dougados, C. Roux
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> to assess bone mineral density (BMD) at lumbar spine and hip in a large cohort of patients with early inflammatory back pain suggestive of axial SpA, and to assess systemic and spinal inflammation (according to Magnetic Resonance Imaging MRI) as determinants of low BMD. <h3>Methods</h3> 708 patients with inflammatory back pain (IBP) suggestive of axial SpA defined by Calin or Berlin criteria were recruited in 25 centers. In 12 centers, lumbar spine, hip BMD and body composition (lean and fat masses) measurements were performed in 332 patients (52.4% women are the basis of this study). Low BMD was defined by T≤-2 at either spine or hip. Clinical, biological, demographic and imaging parameters were compared between low BMD and normal BMD groups. Significant parameters in univariate analyses between low BMD and normal BMD groups were retested in multivariate models to assess determinants of low BMD. <h3>Results</h3> patients (mean age 33.8 years) had a short duration of axial symptoms (mean 1.6 years); 237 (71.4%) fulfilled the ASAS criteria for axial SpA and HLA-B27 was present in 62.1%. A low BMD was present in 42 (12.7%) patients. Multivariate logistic regression showed that parameters significantly associated with low BMD (any site) at baseline were the presence of inflammatory lesions on spine MRI (OR=3.59, p=0.018), and Erythrocyte Sedimentation Rate (ESR) (OR=1.04, p=0.003); female gender was a protective factor (OR=0.03, p=0.001). <h3>Conclusions</h3> this study conducted in a large cohort of young adults with early IBP suggestive of SpA shows that 13% of patients have a low BMD and that the main determinant of this low BMD is spinal inflammation. <h3>Disclosure of Interest</h3> None Declared
Case 51-1968
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A sixty-three-year-old man was admitted to the hospital because of redness and swelling of the eyes. At the age of eighteen years he had had an attack suggestive of rheumatic fever. He had been well until six years previously, when there was the onset of redness, swelling and pain in the ankles. Subsequently, he experienced episodes of migratory polyarthritis involving the shoulders, elbows, wrists, fingers and toes, associated with fever. Five years before admission examination at another hospital disclosed injection of the left conjunctiva and a Grade 1 systolic murmur. Fusiform thickening of the . . .
Leukotriene B<sub>4</sub> Receptor
Authors: TAKEHIKO YOKOMIZO, KAZUYUKI MASUDA, KAZUHIKO KATO, AKIKO TODA, TAKASHI IZUMI, TAKAO SHIMIZU
Journal: American Journal of Respiratory and Critical Care Medicine (2000)

Leukotriene B 4  (LTB 4 ) is a potent chemotactic compound that is synthesized from arachidonic acid, by the action of 5-lipoxygenase and leukotriene A 4 hydrolase (1-3). While 5-lipoxygenase is present to a limited extent in leukocytes (4), LTA 4  hydrolase is present ubiquitously in many tissues including the lung, kidney, spleen, and gastrointestinal tract (5). Cytosolic phospholipase A 2  (cPLA 2 ) plays a major role in releasing arachidonic acid from membrane phospholipids (6). We have cloned a human LTB 4  receptor (BLT), a G protein-coupled receptor (GPCR), by subtraction technology using retinoic acid-differentiated HL-60 cell cDNA libraries (7). In this article, we present data on the structure, signal transduction, and chemotactic activity of BLT.
Smooth Muscle Enriched Long Noncoding RNA ( <i>SMILR</i> ) Regulates Cell Proliferation
Authors: Margaret D. Ballantyne, Karine Pinel, Rachel Dakin, Alex T. Vesey, Louise Diver, Ruth Mackenzie, Raquel Garcia, Paul Welsh, Naveed Sattar, Graham Hamilton, Nikhil Joshi, Marc R. Dweck, Joseph M. Miano, Martin W. McBride, David E. Newby, Robert A. McDonald, Andrew H. Baker
Journal: Circulation (2016)

Background— Phenotypic switching of vascular smooth muscle cells from a contractile to a synthetic state is implicated in diverse vascular pathologies, including atherogenesis, plaque stabilization, and neointimal hyperplasia. However, very little is known about the role of long noncoding RNA (lncRNA) during this process. Here, we investigated a role for lncRNAs in vascular smooth muscle cell biology and pathology. Methods and Results— Using RNA sequencing, we identified &gt;300 lncRNAs whose expression was altered in human saphenous vein vascular smooth muscle cells following stimulation with interleukin-1α and platelet-derived growth factor. We focused on a novel lncRNA (Ensembl: RP11-94A24.1), which we termed smooth muscle–induced lncRNA enhances replication ( SMILR ). Following stimulation, SMILR expression was increased in both the nucleus and cytoplasm, and was detected in conditioned media. Furthermore, knockdown of SMILR markedly reduced cell proliferation. Mechanistically, we noted that expression of genes proximal to SMILR was also altered by interleukin-1α/platelet-derived growth factor treatment, and HAS2 expression was reduced by SMILR knockdown. In human samples, we observed increased expression of SMILR in unstable atherosclerotic plaques and detected increased levels in plasma from patients with high plasma C-reactive protein. Conclusions— These results identify SMILR as a driver of vascular smooth muscle cell proliferation and suggest that modulation of SMILR may be a novel therapeutic strategy to reduce vascular pathologies.
Abstract 4281: Adaptive post-translational regulation of the thiamine transporter THTR1 in breast cancer cells during hypoxic stress
Authors: Jason Zastre, Becky Sweet, Rajgopal Govindarajan
Journal: Cancer Research (2012)

Abstract Purpose: The cellular metabolic re-programming within hypoxic tumor microenvironments involves adaptations that alter the cellular dependence for glycolysis and the pentose phosphate pathway. However, enzymatic activity within these pathways requires an adequate supply and cellular pool of enzyme cofactors. In particular, thiamine is an essential cofactor within key metabolic pathways that are responsible for energy production and anabolic precursor synthesis. Previously, we have reported on the hypoxia-mediated transcriptional regulation of the thiamine transporters within breast cancer cells. Therefore, the purpose of this study was to further our understanding of hypoxia-mediated regulation of thiamine transporters, by examining the intracellular localization and plasma membrane expression of THTR1 during hypoxic stress. Methods: Immunofluorescence was employed to visualize the intracellular localization of THTR1 (SLC19A2) within the non-transformed breast epithelial cell line, MCF10A and breast cancer cells, BT20 and BT474 after 1, 3 and 7 days of 1% O2 exposure. Cell surface biotinlyation assays were utilized to assess changes in the plasma membrane expression of THTR1 after hypoxia exposure. In addition, total THTR1 expression was determined using Western blotting of whole cell lysates and qRT-PCR. Results: The cellular distribution of THTR1 was predominantly localized in the plasma membrane for the non-transformed MCF10A cells, but was predominantly intracellular in the breast cancer cells, BT20 and BT474. No change in total mRNA or cellular THTR1 protein expression was found after hypoxic exposure. However, THTR1 exhibited a time dependent increase in plasma membrane localization after 1% O2 exposure. This observation was confirmed with an increase in THTR1 plasma membrane expression using cell surface biotinylation pull down assays. Conclusions: We conclude that hypoxic stress induces the intracellular trafficking of the thiamine transporter THTR1 to the plasma membrane. These results suggest that post-translational modification of THTR1 during hypoxic exposure may be an essential adaptive cellular response to increase intracellular supply of thiamine to support glycolytic metabolism. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4281. doi:1538-7445.AM2012-4281
Acoustic Findings in a Patient with Radiation Pneumonitis
Authors: Raymond Murphy, Andrey Vyshedskiy
Journal: New England Journal of Medicine (2010)

A 77-year-old woman presented to the hospital with shortness of breath and fever, 2 months after receiving radiation therapy to the right chest for breast cancer. A diagnosis of radiation pneumonitis was made, and the patient was treated with glucocorticoids. Serial chest radiography revealed irregular opacifications, predominantly in the right hemithorax (as seen on the third day after admission [Panel A] and the fifth day [Panel B]). The opacifications decreased markedly after treatment (as seen on day 72 [Panel C]). A lung-sound recorder was used for auscultation of 14 sites on the thorax. The results of the sound analysis are . . .
AB0404 Association between arterial stiffness and pulmonary arterial hypertension in systemic lupus erythematosus
Authors: J. H. Lee, G.-T. Kim, S.-H. Baek
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Althogh pulmonary arterial hypertension (PAH) is a severe manifestation of systemic lupus erythematosus (SLE), the pathogenesis of PAH associated with SLE is yet unclear. <h3>Objectives</h3> In this study, we evaluated the carotid atherosclerosis, elastic properties of the common carotid artery (CCA), reflected by the values of strain of the carotid artery wall based on the speckle tracking imaging, and investigated the association between the parameters of carotid arterial stiffness and clinical, laboratory parameters of systemic inflammatory activity in SLE patients accompanied with PAH. <h3>Methods</h3> Measurement of carotid artery strain parameters and Doppler echocardiography was performed in 50 patients with SLE. Fifty healthy volunteers (52.1 ± 12.0 years, women) from the health screening center were selected as control group. Exclusion criteria for both groups were smoking (in the last 5 years), diabetes mellitus (DM), hypertension, hypercholesterolemia, pregnancy, renal failure, chronic hepatopathy, nephrotic syndrome, and hypothyroidism. We also excluded patients with symptoms or signs of right heart failure and patients with pulmonary hypertension associated with left-sided heart disease, pulmonary thromboembolism, hypoxemia, or known other causes of secondary pulmonary hypertension. PAH was diagnosed if the peak systolic pressure gradient at the tricuspid valve was more than 40 mmHg. All patients were subjected to full history taking, laboratory studies and chest x-ray. SLE activity was assessed by SLE disease activity index (SLEDAI). <h3>Results</h3> In 50 SLE patients, PAH was detected in 6 patients (16 %). Patients with PHT showed reduced RV function represented by higher RV myocardial performance index and reduced RV strain. Significantly higher frequency of anti-cardiolipin antibodies were found in patients with PAH versus those without (P = 0.008). BaPWV and positive ACL were significantly associated with occurrence of PAH in SLE (P = 0.007, P = 0.006 respectively). No significant correlations were found between pulmonary artery pressure, disease duration, SLE Disease Activity Index (SLEDAI), ESR, and anti-ds DNA titers. <h3>Conclusions</h3> Patients with SLE have an increased risk of PAH. Positive anti-cardiolipin antibodies and was significant predictors of pulmonary hypertension in our study. The significant association of LAC and presence of APS in PAH cases suggests that thrombosis may play an important role in PAH with SLE. <h3>References</h3> <h3>Disclosure of Interest</h3> None Declared
Abstract 5185: Evaluation of biomarker candidate genes for prostate cancer metastasis
Authors: Niradiz Reyes, Alfonso Bettin, Juan Rebollo, Raj Tiwari, Jan Geliebter
Journal: Cancer Research (2011)

Abstract Prostate cancer is the most frequently diagnosed malignancy in men and although effective treatment is possible for early stage disease, advanced prostate cancer has a very poor prognosis. Thus, identification of biomarkers that can accurately and reliably diagnose prostate cancer in its early stages is urgently needed. MatLyLu and Dunning G are rat prostate cancer cell lines which have different metastatic capabilities. Using microarray analysis we previously identified a set of metastasis-associated genes that are over-expressed in MatLyLu. Genes found to be differentially expressed include several previously associated with the metastatic process, but not previously reported in prostate cancer. We also have found differential expression of genes that code for several proteoglycans involved in epithelial cell-extracellular matrix interaction, cell adhesion molecules, genes related to motility, growth factor receptors, and tumor suppressor genes. We are currently validating the expression of these candidate genes in human prostate cancer cell lines with different metastatic abilities (LNCaP, PC3, PWR-1E) and in clinical samples of prostate cancer at different disease stages using quantitative real time PCR (qRT-PCR) and immunohistochemistry. A better understanding of the molecular events leading to the metastatic prostate cancer phenotype will help to further identify genes or gene-products involved in this process, which may prove useful as biomarkers for diagnosis and/or prognosis of the disease. Project code: 110745921483. Supported by Colciencias Grant # RC No.462-2008 Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5185. doi:10.1158/1538-7445.AM2011-5185
Jugular Venous C-V Wave in Severe Tricuspid Regurgitation
Authors: Nagendra Boopathy Senguttuvan, Ganesan Karthikeyan
Journal: New England Journal of Medicine (2012)

An 18-year-old man presented with a history of progressive anasarca and exertional dyspnea. His jugular venous pressure was elevated and showed prominent systolic pulsations that were eliminated when gentle pressure was applied at the base of the neck.