tbuckley/cabot-search huggingface dataset:
Survey on the modalities of coping with changes in their physical aspect enacted by oncological patients
Authors: G. Vicario, K. Stocco, G. Sgarbossa, L. Sartor, M. Bortolin, E. Scelzi, F. Piazza, P. Manente
Journal: Journal of Clinical Oncology (2008)

9625 Background: Cancer frequently causes physical changes that are difficult to accept; individuals looking at themselves in the mirror continously recall to their mind the disease. Moreover, surgical, radiation and medical therapy may transiently or permanently change the physical look of patients. Methods: we assessed the modalities utlized by cancer patients to cope with a mutated physical aspect upon different treatments (chemotherapy, radiation therapy, surgery, other procedures). A questionnaire was administered to 80 consecutive patients followed by our Unit. Results: The compliance to the survey was 100%. Even though not requested, in 38% of cases patients undersigned the questionnaire and 62% put a title or specification (i.e. “a patient”, “ a retired teacher”, etc.). To the question: “Me and the mirror: a relationship of hate or love ?”, 52% answered “hate”, 7% “indifferent”, 41% “love”. 97% of patients indicated a change in the perception of his/her body becuase of: surgery (13%), catheters insertion (15%), weight gain (15%), weight loss (17%), steroid therapy (12%), chemotherapy (28%). 50% of patients expressed the desire to be helped to face the changes in the body look: of them, 90% asked for support coming from figures external to the caring team: phsycologist (35%), oher physicians (26%); phsycologist fo relatives (15%), other figures (priest, relatives) (24%). Conclusions: This survey shows that almost all the patients undergoing oncological therapies experienced the perception of a worsening of their physical aspect. About 50% of them looked for support. This condition generated anxiety and fear. In about 50% of cases it was possible to verify a radical change in the hierarchy of basic values: while the physical aspect was essential before the disease onset, other issues predominated afterwards, such as life planning, social life, affections. Moreover, beyond the support coming from the caring personnel, it became indispensable that done by the psychologist, relatives and other professional figures. No significant financial relationships to disclose.
Prolonged T Cell Persistence, Homing to Marrow and Selective Targeting of Antigen Positive Tumor in Multiple Myeloma Patients Following Adoptive Transfer of T Cells Genetically Engineered to Express an Affinity-Enhanced T Cell Receptor Against the Cancer Testis Antigens NY-ESO-1 and Lage-1
Authors: Michael Kalos, Aaron P. Rapoport, Edward A. Stadtmauer, Dan T. Vogl, Brendan M Weiss, Gwendolyn K. Binder-Scholl, Dominic P. Smethurst, Irina Kulikovskaya, Minnal Gupta, Timothy L Macatee, Jeffrey M Finklestein, Joanna E. Brewer, Alan D. Bennett, Andrew B. Gerry, Nick J. Pumphrey, Helen K. Tayton-Martin, Elizabeth Veloso, Zhaohui Zheng, Ashraf Z. Badros, Saul Yanovich, Gorgun Akpek, Holly McConville, Sunita Philip, Bruce L. Levine, Bent K. Jakobsen, Carl H. June
Journal: Blood (2012)
A Pilot Study Examining the Severity and Outcome of the Post–Cardiac Arrest Syndrome
Authors: Michael W. Donnino, Joseph C. Miller, Matthew Bivens, Michael N. Cocchi, Justin D. Salciccioli, Sarah Farris, Shiva Gautam, Donald Cutlip, Michael Howell
Journal: Circulation (2012)

Cardiac arrest occurs in >400 000 patients in the United States per year, and mortality rates vary across the country. Whether variations in cardiac arrest outcome are the result of differences in hospital or patient characteristics remains understudied. We tested whether hospital-independent factors would account for the difference in outcome between 2 geographically distinct hospitals.Consecutive adult (age >18 years) out-of-hospital cardiac arrests were considered for analysis. The primary outcome was in-hospital mortality. Predictor variables were classified according to whether they were hospital-independent or whether they could be related to the hospital's quality of care. Only hospital-independent variables were considered for the analysis. Sequential logistic modeling was used to assess outcome. A propensity score was derived and was used in subsequent multivariate logistic regression to predict hospital outcome. A total of 208 subjects were included. Overall mortality in the Detroit cohort was 87% in comparison with 61% in the Boston cohort (odds ratio: 4.4; 95% confidence interval: 2.2-8.8). After sequential adjustments for baseline covariates, out-of-hospital cardiac arrest score and propensity score, city was not significantly associated with mortality (odds ratio: 1.16; 95% confidence interval: 0.45-2.97). After propensity matching there was no significant difference in the odds ratio for death between the 2 cities (odds ratio: 1.15; 95% confidence interval: 0.51-2.61).In this pilot study, we found that pre- and intra-arrest conditions contribute substantially to the severity of the postarrest syndrome and on outcomes. Postarrest quality-of-care evaluations should include inherent differences in the presenting syndrome rather than a crude mortality rate.
Mannose Labeled Liposome-Encapsulated Doxorubicin Is Effective in the Management of Experimental Immune Thrombocytopenic Purpura Model Mice.
Authors: Yoji Ishida, Kazunori Murai, Syugo Kowata, Tatsuo Oyake, Ryo Suzuki, Kazuo Maruyama
Journal: Blood (2006)
IL-21 and CpG ODN Are Synergistic in Their Ability To Induce Apoptosis of Chronic Lymphocytic Leukemia (CLL) Cells and Benign B1 Cells.
Authors: Bernd Jahrsdoerfer, Sue E. Blackwell, James E. Wooldridge, Melinda W. Andreski, Laura S. Jacobus, Christiana M. Taylor, George J. Weiner
Journal: Blood (2005)
High-Dose Cytoxan, Etoposide, and Cisplatin Followed by Autologous Hematopoietic Cell Transplantation for the Treatment of Hodgkin Lymphoma: A 20-Year Single-Institutional Experience.
Authors: Thomas R. Klumpp, Moshe C. Chasky, Robert V. Emmons, Mary E. Martin, James L. Gajewski, Kenneth F. Mangan
Journal: Blood (2007)
Array Comparative Genomic Hybridization Revealed Polyclonality In Acute Type Adult T-Cell Leukemia/Lymphoma and PTCL NOS
Authors: Akira Umino, Masao Nakagawa, Atae Utsunomiya, Kunihiro Tsukasaki, Naoyuki Katayama, Masao Seto
Journal: Blood (2010)
Modelling BCR-ABL1 Dynamics in Patients with Chronic Myeloid Leukemia in Chronic Phase (CML-CP) during Frontline Therapy with High-Dose Imatinib, Nilotinib, or Dasatinib.
Authors: Adam Olshen, Alfonso Quintαs-Cardama, Hagop M. Kantarjian, Mithat Gonen, Franziska Michor, Jorge Cortes
Journal: Blood (2008)
Biology and Outcome of 85 Adults with Acute Lymphoblastic Leukemia (ALL) with t(4;11)/MLL-AF4 Treated in the UKALL XII/ECOG 2993 Study
Authors: David I Marks, Anthony V Moorman, Lucy Chilton, Elisabeth Paietta, Gordon de Wald, Adele K Fielding, Anthony H. Goldstone, Mark R Litzow, Selina M. Luger, Andrew McMillan, Jacob M. Rowe, Martin S Tallman, Hillard M. Lazarus
Journal: Blood (2012)
Phase I Trial Evaluating the Safety and Biological Activity of Iboctadekin (rhIL-18) in Combination with Rituximab in Patients with CD20+ B Cell Non-Hodgkin's Lymphoma,
Authors: Michael J. Robertson, John Bauman, Olivia Gardner, Zdenka Jonak, Herbert Struemper, Fiona Germaschewski, Kevin M. Koch, Sharon Murray, Jill Weisenbach, John Toso
Journal: Blood (2011)
Trump expands antiabortion rule to include all global health funding
Authors: Anne Gulland
Journal: BMJ (2017)

Women and children in the developing world will be hit by US president Donald Trump’s decision to restrict government funding to organisations providing advice or assistance on abortions, international organisations have warned.

On 23 January Trump signed one of many executive orders to reinstate the global gag rule, which means that the US government cannot give money to international organisations providing abortion services or advice. However, the order said that it would expand the rule to include “global health assistance furnished by all departments or agencies.”

Suzanne Ehlers, chief executive of the global reproductive health organisation PAI, described the order in a tweet as the “global gag rule on steroids.”

PAI said in a newsletter that the expansion meant that foreign non-government organisations receiving …
Outcome of Patients with Multiple Myeloma Treated with Autologous Stem Cell Transplantation in the Era of Novel Therapies.
Authors: Hani Hassoun, Heather Landau, Chirag Surti, Nelly G. Adel, Xiaoyu Jia, Elyn R Riedel, Bhutani Manisha, Raymond Comenzo, Alexander Lesokhin, David J. Chung, Jennifer Ciminiello, Emily McCullagh, Stephen D Nimer
Journal: Blood (2009)
Efficacy and Safety of Once-Daily Oral Deferasirox (Exjade®) during a Median of 2.7 Years of Treatment in Heavily Iron-Overloaded Patients with β-Thalassemia
Authors: Ali Taher, Amal El-Beshlawy, Mohsen Saleh Elalfy, Kusai Al Zir, Shahina Daar, Ghazi Damanhouri, Dany Habr, Ulrike Kriemler-Krahn, Abdel Hmissi, Abdullah Al Jefri
Journal: Blood (2008)
Clonal or not clonal? Investigating hospital outbreaks of KPC-producing Klebsiella pneumoniae with whole-genome sequencing
Authors: E. Ruppé, F. Olearo, D. Pires, D. Baud, G. Renzi, A. Cherkaoui, D. Goldenberger, A. Huttner, P. François, S. Harbarth, J. Schrenzel
Journal: Clinical Microbiology and Infection (2017)
Outgrowing Endothelial Cells That Are Derived from Human Umbilical Cord Blood Improve Neovascularization in Hind-Limb Ischemia.
Authors: Eun-Sun Yoo, KiHwan Kwon, Jee-Young Ahn, Soo-Ah Oh, Hye-Jung Chang, Moon-Young Choi, Yeung-Chul Mun, Kyoung-Eun Lee, Chu-Myong Seong
Journal: Blood (2007)
The Allosteric AKT Inhibitor MK-2206 Demonstrates Potent Antiproliferative Activity in Lymphoma Cells and Synergizes with the HDAC Inhibitor Vorinostat,
Authors: Daniela Buglio, Manuela Lemoine, Jaymie Estrella, Sattva S. Neelapu, Richard Eric Davis, Laurence Doyle, Richard F Little, Donald Berry, Anas Younes
Journal: Blood (2011)
Velcade (V)-Thalidomide (T)-Dexamethasone (D) for Advanced and Refractory Multiple Myeloma (MM): Long-Term Follow-Up of Phase I–II Trial UARK 2001-37: Superior Outcome in Patients with Normal Cytogenetics and No Prior T.
Authors: Maurizio Zangari, Bart Barlogie, Michael J. Burns, Vanessa Bolejack, Klaus A. Hollmig, Frits van Rhee, Mauricio Pineda-Roman, Francesca Elice, Guido J. Tricot
Journal: Blood (2005)
Pseudomonas syringae Type III Effector HopBB1 Promotes Host Transcriptional Repressor Degradation to Regulate Phytohormone Responses and Virulence
Authors: Li Yang, Paulo José Pereira Lima Teixeira, Surojit Biswas, Omri M. Finkel, Yijian He, Isai Salas-Gonzalez, Marie E. English, Petra Epple, Piotr Mieczkowski, Jeffery L. Dangl
Journal: Cell Host & Microbe (2017)
Full time GP workforce fell by nearly 100 last year
Authors: Jacqui Wise
Journal: BMJ (2017)

Latest figures for England show that the number of full time GPs fell by 97 last year, despite government promises to expand the workforce by 5000 by 2020.1

The report by NHS Digital shows that there were 34 495 full time equivalent GPs in September 2016, down from 34 592 a year earlier (a drop of 0.3%). The latest data show that the overall headcount fell by 12 from 41 877 to 41 865. Just over half (57%) of GPs were partners, the …
Bladder cancer patterns of pelvic failure: Implications for adjuvant radiation therapy.
Authors: Brian Christopher Baumann, Thomas J. Guzzo, Jiwei He, David J. Vaughn, Stephen Michael Keefe, Neha Vapiwala, Curtiland Deville, Justin E. Bekelman, Kai Tucker, Wei-Ting Hwang, S. Bruce Malkowicz, John Paul Christodouleas
Journal: Journal of Clinical Oncology (2012)

293 Background: Local-regional recurrences (LF) after radical cystectomy with or without chemotherapy are common in patients with locally advanced disease. Adjuvant radiation (RT) could reduce LF, but toxicity discouraged its use. Modern RT with reduced morbidity has rekindled interest but requires knowledge of pelvic failure patterns to design appropriate clinical target volumes. Methods: 5-yr LF rates after radical cystectomy plus pelvic lymph node dissection with or without chemotherapy were determined for 8 pelvic sites among 442 patients with urothelial carcinoma of the bladder. The impact on the pattern of failure of pathologic stage, margin status, nodal involvement, and extent of node dissection was assessed using competing risk statistical methods. The percentage of patients whose sites of LF would be completely encompassed within various hypothetical clinical target volumes for post-operative radiation were calculated. Results: Stage pT3-4 patients had higher 5-yr LF rates in virtually all pelvic sites compared to pT0-2 patients. Among pT3-4 patients, margin status significantly altered the pattern of failure while extent of node dissection and pathologic nodal involvement did not. Stage pT3-4 patients with negative margins failed predominantly in the iliac/obturator nodes. Failures in the cystectomy bed and presacral region were significantly higher in pT3-4 patients with positive rather than negative margins. 76% of pT3-4 patients with negative margins who failed would have had all sites of LF included within clinical target volumes encompassing the iliac/obturator nodes, but only 57% of pT3-4 patients with positive margins would have their LF sites covered by such target volumes. Including the cystectomy bed and presacral region in the clinical target volume when margins were positive increased the percentage of encompassed failures to 91%. Conclusions: In adjuvant RT protocols, the obturator and iliac regions should be targeted in pT3-4 tumors with negative margins; coverage of presacral region and cystectomy bed is advised for pT3-4 with positive margins.
The K247R Substitution in ABL Tyrosine Kinase Domain Is Not a Mutation Leading to Imatinib Resistance but a Polymorphism Rarely Present in CML Patients and in Normal Subjects.
Authors: Kaddour Chabane, Franck Nicolini, Jean-Michel Cayuela, Philippe Rousselot, Xavier Thomas, Annick Bertholin, Mauricette Michallet, Jean-Pierre Magaud, Sandrine Hayette
Journal: Blood (2005)
Prognosis of patients with renal cell carcinoma with disease recurrence following nephrectomy for localized disease.
Authors: Nobuo Shinohara, Takashige Abe, Satoru Maruyama, Ataru Sazawa, Katsuya Nonomura
Journal: Journal of Clinical Oncology (2012)

400 Background: We investigated the prognosis of Japanese patients with recurrent renal cell carcinoma (RCC) following nephrectomy, and analyzed the prognostic impact of metastasectomy and Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification in these patients. Methods: Between 1995 and 2005, 214 patients with recurrent RCC were the subjects of this retrospective analysis. At recurrence, MSKCC risk classification was used to classify patients as being at favorable, intermediate, and poor risk. The endpoint of the present study was overall survival (OS) from time of recurrence. Relationships between overall survival and potential prognostic factors were assessed using the Cox proportional hazard model. Results: Median time to recurrence following nephrectomy was 25 months. At recurrence, 148 (69%) patients had metastasis in one organ and lung was the most common site of recurrence (123 pts, 57%). The median survival from the time of recurrence was 40 months; the estimated 2-year survival rate was 66% (95% CI 60-73). When the MSKCC risk classification was applied to the patients, the median overall survival was not reached, 29 months, and 11 months in the patients classified as favorable (59 pts), intermediate (101 pts), and poor risk (24 pts), respectively. Metastasectomy was performed in 76 (36%) patients. The median survival from the time of recurrence in these patients was 122 months, which was significantly longer than the median survival (27 months) of patients who did not undergo metastasectomy (p&lt;0.001). Multivariate analysis demonstrated that a better risk category of MSKCC risk classification and metastasectomy were associated with more favorable survival (p&lt;0.001). Conclusions: In patients with recurrent RCC following nephrectomy for localized disease, patients classified as favorable risk according to MSKCC risk classification have a good opportunity for long-term survival, especially those who undergo metastasectomy.
Developing a dedicated dermatology service for allogeneic bone marrow transplant recipients
Authors: R.N. Matin, R. Danby, E. Gibbons, V. Venning, L. Rowley, D. Barton, R. Pawson, T. Littlewood, J.R. Reed, A. Peniket
Journal: British Journal of Dermatology (2017)

Following allogeneic stem cell transplantation, graft versus host disease (GVHD) is a major cause of morbidity and mortality with the commonest organs affected being the skin and oral mucosa. Clinical presentation of cutaneous GVHD is widely variable and 13/30 patients attending a dedicated GVHD clinic were referred to Dermatologists with a specialist interest in GVHD (1). The British Committee for Standards in Haematology GVHD guidelines recommend organ-specific management and supportive care (2) recognising that early input from a Dermatologist is likely to improve clinical outcomes (3). JACIE 6th Edition standards also recommend access to certified specialist trained Dermatologists (4).

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Histologic and Optical Coherence Tomographic Correlates in Drusenoid Pigment Epithelium Detachment in Age-Related Macular Degeneration
Authors: Chandrakumar Balaratnasingam, Jeffrey D. Messinger, Kenneth R. Sloan, Lawrence A. Yannuzzi, K. Bailey Freund, Christine A. Curcio
Journal: Ophthalmology (2017)
Bouveret syndrome and pancreatic acinar cell carcinoma
Authors: Fernando Krebs Cirne Lima, Antônio Atalíbio Hartmann, César Vivian Lopes
Journal: Endoscopy (2017)

Bouveret syndrome and pancreatic acinar cell carcinoma are two rare conditions of the gastrointestinal tract [1] [2] [3] [4]. Herein, we present a case in which both conditions occurred in the same patient.
Making a Fetish of “CPR” Is Not in the Patient's Best Interest
Authors: John J. Paris, M. Patrick Moore,
Journal: The American Journal of Bioethics (2017)

Rosoff and Schneiderman's essay “Irrational Exuberance: Cardiopulmonary Resuscitation as Fetish” (2017) raises an issue first posed by the then Chairman of the Federal Reserve Board, Alan Greenspan...
Disaggregation of Cause-Specific Cardiovascular Disease Mortality Among Hispanic Subgroups
Authors: Fatima Rodriguez, Katherine G. Hastings, Derek B. Boothroyd, Sandra Echeverria, Lenny Lopez, Mark Cullen, Robert A. Harrington, Latha P. Palaniappan
Journal: JAMA Cardiology (2017)

Hispanics are the largest minority group in the United States and face a disproportionate burden of risk factors for cardiovascular disease (CVD) and low socioeconomic position. However, Hispanics paradoxically experience lower all-cause mortality rates compared with their non-Hispanic white (NHW) counterparts. This phenomenon has been largely observed in Mexicans, and whether this holds true for other Hispanic subgroups or whether these favorable trends persist over time remains unknown.To disaggregate a decade of national CVD mortality data for the 3 largest US Hispanic subgroups.Deaths from CVD for the 3 largest US Hispanic subgroups-Mexicans, Puerto Ricans, and Cubans-compared with NHWs were extracted from the US National Center for Health Statistics mortality records using the underlying cause of death based on coding from the International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (I00-II69). Mortality data were evaluated from January 1, 2003, to December 31, 2012. Population estimates were calculated using linear interpolation from the 2000 and 2010 US Census reports. Data were analyzed from November 2015 to July 2016.Mortality due to CVD.Participants included 688 074 Mexican, 163 335 Puerto Rican, 130 397 Cuban, and 19 357 160 NHW individuals (49.0% men and 51.0% women; mean [SD] age, 75 [15] years). At the time of CVD death, Mexicans (age, 67 [18] years) and Puerto Ricans (age, 68 [17] years) were younger compared with NHWs (age, 76 [15] years). Mortality rates due to CVD decreased from a mean of 414.2 per 100 000 in 2003 to 303.3 per 100 000 in 2012. Estimated decreases in mortality rate for CVD from 2003 to 2012 ranged from 85 per 100 000 for all Hispanic women to 144 per 100 000 for Cuban men, but rate differences between groups vary substantially, with Puerto Ricans exhibiting similar mortality patterns to NHWs, and Mexicans experiencing lower mortality. Puerto Ricans experienced higher mortality rates for ischemic and hypertensive heart disease compared with other subgroups, whereas Mexicans experienced higher rates of cerebrovascular disease deaths.Significant differences in CVD mortality rates and changes over time were found among the 3 largest Hispanic subgroups in the United States. Findings suggest that the current aggregate classification of Hispanics masks heterogeneity in CVD mortality reporting, leading to an incomplete understanding of health risks and outcomes in this population.
CD38 Induces Homing of Chronic Lymphocytic Leukemia Cells to the Lymphoid Organs through a Functional Interplay with CXCR4.
Authors: Silvia Deaglio, Semra Aydin, Tiziana Vaisitti, Luciana Bergui, Davide Rossi, Giovanni D'Arena, Lisa Bonello, Maurizia Mello Grand, Giovanna Chiorino, Alberto Horenstein, Gianluca Gaidano, Fabio Malavasi
Journal: Blood (2009)
Results From the Phase II Dose Expansion of Cyclophosphamide, Carfilzomib, Thalidomide and Dexamethasone (CYCLONE) in Patients with Newly Diagnosed Multiple Myeloma
Authors: Joseph R. Mikhael, Craig B. Reeder, Edward N. Libby, Luciano J. Costa, P. Leif Bergsagel, Francis Buadi, Angela Mayo, Katherine Gano, Cassandra Wolf, Amylou Constance Dueck, A. Keith Stewart
Journal: Blood (2012)