tbuckley/cabot-search huggingface dataset:
Obinutuzumab (GA101) in Combination with FC or CHOP in Patients with Relapsed or Refractory Follicular Lymphoma: Final Results of the Phase I GAUDI Study (BO21000)
Authors: John Radford, Andrew Davies, Guillaume Cartron, Franck Morschhauser, Gilles Andre Salles, Robert E. Marcus, Michael K. Wenger, Elina Asikanius, Elisabeth Wassner-Fritsch, Umberto Vitolo
Journal: Blood (2011)
Association Between Response to Acid-Suppression Therapy and Efficacy of Antireflux Surgery in Patients With Extraesophageal Reflux
Authors: Joseph T. Krill, Rishi D. Naik, Tina Higginbotham, James C. Slaughter, Michael D. Holzman, David O. Francis, C. Gaelyn Garrett, Michael F. Vaezi
Journal: Clinical Gastroenterology and Hepatology (2016)
Efficacy and safety of withholding antimicrobial treatment in children with cancer, fever and neutropenia, with a demonstrated viral respiratory infection: a randomized clinical trial
Authors: M.E. Santolaya, A.M. Alvarez, M. Acuña, C.L. Avilés, C. Salgado, J. Tordecilla, M. Varas, M. Venegas, M. Villarroel, M. Zubieta, A. Toso, A. Bataszew, M.J. Farfán, V. de la Maza, A. Vergara, R. Valenzuela, J.P. Torres
Journal: Clinical Microbiology and Infection (2016)
AB0917 Pulmonary Manifestations in Patients with IGG4-Related Disease at A Tertiary Care Institute: Table 1.
Authors: R. Banka, Y. Gc, C. Balakrishnan, R. Samant, L. Pinto, P.S. Sagdeo
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> IgG4-Related Disease (IgG4 RD) is a rare immune-mediated disease with multi-organ involvement. <h3>Objectives</h3> To describe pulmonary manifestations of patients with IgG4-RD. <h3>Methods</h3> Chart review was performed of consecutive patients diagnosed with IgG4 RD between 2009–2014 at the PD Hinduja National Hospital, Mumbai. Included patients fulfilled diagnostic criteria of Japanese Ministry of Health, Labour and Welfare guidelines, 2011.Their clinical features, laboratory findings were noted down. <h3>Results</h3> 8 of 11 patients with IgG4 RD had pulmonary manifestations. Ages of presentation ranged from 15–73 years.6 patients were female. Average delay in diagnosis was 9 months. Prior to diagnosis, 3 patients received empiric antituberculous drugs and bronchoalveolar lavage performed in 3 patients was non-diagnostic. The right mainstem bronchus was found to be narrowed in 1 patient. The serum IgG4 levels were elevated in all patients. Median IgG4 level was 4.76 mg/dl (IQR 3.26, 6.1).Presenting symptoms, thoracic CT and histopathological findings are summarized below <h3>Conclusions</h3> Pulmonary involvement in IgG4 RD is common and should be sought for in patients diagnosed with the disease. <h3>References</h3> Umehara, H. et al. Comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD), 2011. Mod. Rheumatol. 22, 21–30 (2012). <h3>Disclosure of Interest</h3> None declared
Prognostic Value of Interim and End of Treatment FDG-PET/CT Scan Results in Adult Patients with Burkitt Lymphoma - a Retrospective Analysis of a Single Center Cohort
Authors: Eldar Priel, Meirav Kedmi, Tima Davidson, Ginette Schiby, Elena Ribakovsky, Ohad Benjamini, Arnon Nagler, Abraham Avigdor
Journal: Blood (2015)
A Novel Non-Canonical Phosphodegron Regulates EZH2 Proteasomal Degradation and H3K27 Trimethylation Activity in Hematopoietic Malignancies
Authors: Anagh A Sahasrabuddhe, Xiaofei Chen, Thirunavukkarasu Velusamy, Fuzon Chung, Megan S Lim, Kojo S.J. Elenitoba-Johnson
Journal: Blood (2014)
AB0203 Polyclonal Immunoglobulin Light Chains Levels in Elderly People with Rheumatoid Arthritis: Real Clinical Practice – The Influence of SDMARDs
Authors: I.V. Pozharov, Z.U. Mutovina, A.D. Astakhova, E.V. Ryazantseva, A.V. Gordeev
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Polyclonal immunoglobulin light chains (PLC) represent biomarkers of B cell activity in rheumatoid arthritis (RA) and are associated with increased mortality in general population. PLC levels appear to be elevated during preclinical and active periods of RA. Serum k and l light chains are important inflammatory indexes and may be used as indicators of disease activity in RA. <h3>Objectives</h3> To explore association between serum PLC in cohorts of patients with RA depending on treatment and to determine whether PLC can be used as markers of treatment effectiveness. <h3>Methods</h3> 150 patients with RA untreated and treated with sDMARDs were included in the study (n=52, n=98, respectively), and 31 patient with osteoarthritis. Approximately 75% of patients in all groups were elderly people. Serum levels of PLC were measured by immune nephelometry. <h3>Results</h3> Median [lower and upper quartiles] polyclonal k and λ light chains serum concentrations in cohort of untreated RA patients were significantly higher in comparison with osteoarthritis and treated RA patients (κ: 3.1 [2.7; 3.6] vs 2.6 [2.1; 3.3] and 2.6 [2.3; 3.1] g/l, H=12.1, p&lt;0,01; λ: 1.7 [1.3; 1.9] vs 1.4 [1.2; 1.8] and 1.3 [1.2; 1.7] g/l, p=0.014). Comparing groups treated with methotrexate, sulfasalazine and leflunomide (n=48, 15 and 16, respectively) showed no statistically significant difference of PLC levels. It appeared that treatment with methotrexate during at least 6 months reduced serum concentrations of PLC in patients with RA (κ untreated 3.0 [2.6; 3.4] vs κ methotrexate 2.6 [2.0; 2.8], p&lt;0.01; λ untreated 1.8 [1.6; 2,05] vs λ methotrexate 1,4 [1.0; 1,7], p&lt;0.01). <h3>Conclusions</h3> PLC can be used as markers of treatment with sDMARDs effectiveness among elderly patients with multimorbidity. <h3>References</h3> Dispenzieri A, Katzmann JA, Kyle RA, et al. Use of Nonclonal Serum Immunoglobulin Free Light Chains to Predict Overall Survival in the General Population. Mayo Clinic Proceedings. 2012;87(6):517–523. doi: 10.1016/j.mayocp.2012.03.009. Brebner JA, Stockley RA. Polyclonal free light chains: a biomarker of inflammatory disease or treatment target? F1000 Medicine Reports. 2013;5:4. doi:10.3410/M5-4. Deng X, Crowson CS, Rajkumar SV, Dispenzieri A, et al. Elevation of serum immunoglobulin free light chains during the preclinical period of rheumatoid arthritis. J Rheumatol. 2015 Feb;42(2):181–7. doi: 10.3899/jrheum.140543. <h3>Disclosure of Interest</h3> None declared
Abstract 116: Arterial Endothelial Cell Has Stronger Angiogenic Potential Compared To Venous Endothelial Cell Through Up-regulation Of Endogenous FGF2 And FGF5 Expression In 3D Microfluidic System
Authors: Ha-Rim Seo, Hyo Eun Jeong, Hyung Joon Joo, Seung-Cheol Choi, Jong-Ho Kim, Chi-Yeon Park, Ji-Hyun Choi, Long-Hui Cui, Seok Chung, Do-Sun Lim
Journal: Circulation Research (2014)

Background: Human body contains many kinds of different type of endothelial cells (EC). However, cellular difference of their angiogenic potential has been hardly understood. We compared in vitro angiogenic potential between arterial EC and venous EC and investigated its underlying molecular mechanisms. Method: Used human aortic endothelial cells (HAEC) which was indicated from arterial EC and human umbilical vein endothelial cells (HUVEC) indicated from venous EC. To explore angiogenic potential in detail, we adopted a novel 3D microfluidic angiogenesis assay system, which closely mimic in vivo angiogenesis. Results: In 3D microfluidic angiogenesis assay system, HAEC demonstrated stronger angiogenic potential compared to HUVEC. HAEC maintained its profound angiogenic property under different biophysical conditions. In mRNA microarray sorted on up- regulated or down-regulated genes, HAEC demonstrated significantly higher expression of gastrulation brain homeobox 2 (GBX2), fibroblast grow factor 2 (FGF2), FGF5 and collagen 8a1. Angiogenesis-related protein assay revealed that HAEC has higher secretion of endogenous FGF2 than HUVEC. HAEC has only up-regulated FGF2 and FGF5 in this part of FGF family. Furthermore, FGF5 expression under vascular endothelial growth factor-A (VEGF-A) stimulation was higher in HAEC compared to HUVEC although VEGF-A augmented FGF5 expression in both HAEC and HUVEC. Those data suggested that FGF5 expression in both HAEC and HUVEC is partially dependent to VEGF-A stimulate. HUVEC and HAEC reduced vascular density after FGF2 and FGF5 siRNA treat. Conclusion: HAEC has stronger angiogenic potential than HUVEC through up-regulation of endogenous FGF2 and FGF5 expression
Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial
Authors: Finbar J K O'Callaghan, Stuart W Edwards, Fabienne Dietrich Alber, Eleanor Hancock, Anthony L Johnson, Colin R Kennedy, Marcus Likeman, Andrew L Lux, Mark Mackay, Andrew A Mallick, Richard W Newton, Melinda Nolan, Ronit Pressler, Dietz Rating, Bernhard Schmitt, Christopher M Verity, John P Osborne
Journal: The Lancet Neurology (2016)
AB0636 Interstitial Lung Disease in Scleroderma Portuguese Patients: Table 1.
Authors: S.I. Sousa, A. Duarte, I. Cordeiro, L. Teixeira, J. Canas da Silva, A. Cordeiro, M.J. Santos
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic sclerosis (SSc) is a rheumatic disorder characterized by inflammation and fibrosis involving the skin as well as internal organs, including the lung. <h3>Objectives</h3> This study was conducted to characterize SSc patients with ILD and determine predictor features for the presence of ILD. <h3>Methods</h3> A retrospective evaluation of SSc patients from our Rheumatology department was undertaken. ILD was defined according to imaging findings in high-resolution CT (HRCT) combined with functional parameters. Demographic features, auto-antibodies, spirometry, diffusion capacity for carbon monoxide (DLCO) measurement, echocardiography and 6-minute walk test were compared between groups with and without ILD using parametric tests and non-parametric tests. Predictor factors were established by logistic regression analyses. <h3>Results</h3> One hundred and three SSc patients with current mean age of 60.2±14.1y and mean disease duration of 10.0±9.6y were evaluated. Thirty-four (35.8%) patients were diagnosed with ILD, of whom 13 had limited cutaneous SSc, 14 had diffuse cutaneous SSc, 2 sine sclerodema and 5 overlap syndroms. ANA was positive in 100% cases, anti-Scl70 was found in 55% and anti-centromere antibody positivity was found in 15% of patients. HRCT revealed diffuse parenchymal lung disease involvement &gt;20% in 18 (53%) cases, with the majority showing a predominant honeycombing pattern. Spirometry showed a restrictive pattern in 8 patients and 1 had obstruction. The DLCOsb was abnormal in 7 patients. Three patients had pulmonary hypertension confirmed by right heart catheterization, 2 patients classified as group 1 and 3 and 1 patient of group 5. About 63% of ILD patients were ever treated with corticosteroids and 27% with cyclophosphamide, which were the most common drugs used. Two patients were also treated with rituximab. In this ILD-group, 5 deaths were recorded, 2 due to cancer, 1 abdominal sepsis, 1 pulmonary hypertension and 1 of unknown cause. Comparison of these ILD patients with non-ILD patients revealed some significantly differences (Table 1). Multivariate analysis showed that digital ulcers (OR=31.6, 95% CI 3.09 to 321.91), Anti-Scl70 antibody positivity (OR=10.1, 95% CI 1.19 to 85.74) and anti-centromere antibody negativity (OR=0.08, 95% CI 0.01 to 0.83) were independently associated with the presence of ILD. <h3>Conclusions</h3> This study is one of the first studies carried out in Portugal regarding lung involvement in SSc. About one third of the patients had ILD, whose main characteristics are in accordance with other European cohorts. We confirmed that anti-SCL70 positivity, presence of digital ulcers as well as the absence of anti-centromere antibody is independently associated with ILD <h3>Disclosure of Interest</h3> None declared
High iron levels are associated with risk of gestational diabetes, study finds
Authors: Susan Mayor
Journal: BMJ (2016)

Elevated iron levels may raise the risk of developing gestational diabetes, show the results of a prospective study that potentially questions routine iron supplementation in pregnant women with normal iron levels.1

Pregnant women are particularly vulnerable to iron deficiency, so several guidelines recommend routine iron supplementation during pregnancy. Recent research has suggested that larger iron stores are associated with disturbances in glucose metabolism and an …
Outcome with Lenalidomide Plus Dexamethasone Followed By Early Autologous Stem Cell Transplantation in the ECOG-ACRIN E4A03 Randomized Clinical Trial: Long-Term Follow-up
Authors: Noa Biran, Susanna Jacobus, David Siegel, Natalie Scott Callander, Rafael Fonseca, David H. Vesole, Michael E. Williams, Rafat Abonour, Michael S Katz, S. Vincent Rajkumar, Philip R. Greipp
Journal: Blood (2015)
Serum Ferritin, Labile Plasma Iron and Transferrin Saturation: Comparison Between Underlying Anemias with Transfusional Iron Overload Before and After Treatment with Deferasirox.
Authors: John B Porter, Mohsen Elalfy, Vip Viprakasit, Stephane Giraudier, Lee Lee Chan, Yongrong Lai, Ali El-Ali, Nicolas Martin, M Domenica Cappellini
Journal: Blood (2012)
FRI0374 The Diagnostic Value of alpha-1-antitrypsin Phenotype in Patients with Granulomatosis with Polyangiitis (Wegener's Granulomatosis)
Authors: I. Belyaeva, M. Pervakova, S. Lapin, V. Mazurov, A. Chudinov
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Deficiency of alpha-1 protease inhibitor, or alpha-1-antitrypsin (A1AT), predisposes to chronic lung diseases and some extra-pulmonary pathology. Besides classical implications, such as pulmonary emphysema and other associated lung diseases, A1AD is also known to be associated with granulomatosis with polyangiitis (GPA, or Wegener9s). <h3>Objectives</h3> The aim of our study was to evaluate the frequency of mutated A1AT forms and its clinical significance among GPA patients. <h3>Methods</h3> We analysed 38 samples of sera, collected from GPA patients. Detailed clinical data, including Birmingham Vasculitis Activity Score (BVAS), incidence of lung involvement, anti-(Pr3) antibodies concentrations and other laboratory data were collected. We also studied control group of 46 healthy donors. All collected samples underwent A1AT phenotyping by isoelectrofocusing (IEF) and turbidimetric A1AT measurement. <h3>Results</h3> Mutated A1AT variants were revealed in 18.4% (7/38) cases and included following phenotypes: 1ZZ, 4MZ and 2MF. The mean A1AT concentration in samples with pathological genetic A1AT forms was significantly lower (P=0,0038), than in normal A1AT phenotype. According to reference values, only 2 of 7 pathological samples demonstrated decreased A1AT concentration. Comparing BVAS activity, we found that patients with mutated A1AT phenotype had significantly higher vasculitis activity, as well as anti-PR3 antibodies concentration. When analysis of nonspecific systemic inflammation markers was performed, the significant difference (P&lt;0.05) was found only between means of erythrocyte sedimentation rate (ESR) <h3>Conclusions</h3> Laboratory testing to find pathological A1AT forms are not usually ordered for patients with systemic vasculitides. During medical examination of GPA patients the possibility of A1AT deficiency should be considered and may be verificated by IEF. <h3>Disclosure of Interest</h3> None declared
Autologous Non-Myeloablative Hematopoietic Stem Cell Transplantation (NST) for Severe Systemic Lupus Erythematosus.
Authors: Richard K. Burt, Yu Oyama, Laisvyde Statkute, Nela Krosnjar, Larissa Verda, Barbara Kowalska, Ann E. Traynor
Journal: Blood (2004)
Identification of the Involvement of the Tyrosine Kinase C-Ros in the Pathogenesis of Chronic Myelomonocytic Leukemia (CMML)
Authors: Daniela Cilloni, Sonia Carturan, Enrico Bracco, Ilaria Defilippi, Chiara Maffè, Ilaria Iacobucci, Marisa Pautasso, Antonia Rotolo, Emilia Giugliano, Emanuela Messa, Giovanni Martinelli, Giuseppe Saglio
Journal: Blood (2008)
V617F JAK2 Mutation and Bone Marrow Fibrosis Define Subgroups Of Patients With Polycythemia Vera and Essential Thrombocythemia With Shared Clinicobiological Profiles
Authors: Panagiotis Baliakas, Vassiliki Douka, Michalis Iskas, Tasoula Touloumenidou, Angeliki Paleta, Eva Koravou, Anta Cheva, Fotis Iordanidis, Leonidas Sakkas, Damianos Sotiropoulos, Kostas Stamatopoulos, Achilles Anagnostopoulos
Journal: Blood (2013)
Vitamin D Effect On Umbilical Cord Blood Characteristics: A Comparison Between African Americans and Caucasians
Authors: Lamis K Eldjerou, Emma Rosenau, Xiaomin Lu, Clayton Bennett, Michele W. Sugrue, Jonathan Hoyne, Amy Lambert, Lindsay Hertel, Kathleen Sazama, John R Wingard, Abba C Zubair
Journal: Blood (2013)
Outcome of Patients with Light Chain Multiple Myeloma Compared to IgG/IgA Myeloma after Autologous Stem Cell Transplant
Authors: Koji Sasaki, Nina Shah, Qaiser Bashir, Chitra M. Hosing, Uday R. Popat, Yago Nieto, Simrit Parmar, Jatin J. Shah, Donna Weber, Daniel Weissinger, Sheeba K. Thomas, Robert Z. Orlowski, Richard E. Champlin, Muzaffar H. Qazilbash
Journal: Blood (2015)
AB1099-HPR Comparison of The Effect of Daily Living Activities and Depression on Quality of Life in Patients with Ankylosing Spondylitis and Rheumatoid Arthritis: Table 1.
Authors: G. Arin, P. Kisacik, A. Akdogan, L. Kilic, U. Berberoglu, E. Karabulut, O. Dogan, E. Unal
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Increasing activity and improving function are valuable parameters to prevent disability (1,2). The relationship between the functional impairment in depression and the activities of daily living was well known in terms of the quality of life in chronic diseases (3). However, studies comparing these effects on various rheumatic diseases were not sufficient. <h3>Objectives</h3> This study was conducted to compare the effects of depression and activities of daily living on quality of life for the patients with two different rheumatic diseases (Ankylosing Spondylitis (AS) and Rheumatoid Arthritis (RA)). <h3>Methods</h3> 265 patients with AS and 111 patients with RA were included in the study. The demographic data were collected for two groups. Mean age of the study group was 39.88±13.33. All patients were evaluated with disease-specific questionnaires according to their diseases. The patients with AS were asked to fill the Ankylosing Spondylitis Quality of Life Questionnaire (ASQoL) for quality of life, and the Rheumatoid Arthritis Quality of Life Questionnaire (RAQoL) were used for RA patients. Beck Depression Index (BDI) was used to assess depression levels of the subjects, and Health Assessment Questionnaire (HAQ) to assess activities of daily living in both groups. <h3>Results</h3> A mild and positive correlation was found between HAQ (p&lt;0.001, r=0,564), BDI (p&lt;0.001, r=0.477) and RAQoL scores. Similarly, a mild and positive correlation was found between HAQ (p&lt;0.001, r=0.513), BDI (p&lt;0.001, r=0.443) and ASQoL scores. In all patients, there was a fair-mild positive correlation between HAQ and BDI scores (p&lt;0.001, r=0.350) (Table 1). <h3>Conclusions</h3> It is concluded that the depression level and the activities of daily living has similar effects on the quality of life for RA and AS patients. Also depression should be taken into consideration in both rheumatic diseases. <h3>References</h3> Corbacho MI, Dapueto JJ. Assessing the functional status and quality of life of patients with rheumatoid arthritis. Revista brasileira de reumatologia. 2010;50(1):31–43. Kingsley G, Scott IC, Scott DL. Quality of life and the outcome of established rheumatoid arthritis. Best practice &amp; research Clinical rheumatology. 2011;25(4):585–606. Braun J, Sieper J. Anklyosing Spondylitis. The Lancet. 2007;369(9570):1379–1390. <h3>Disclosure of Interest</h3> None declared
Cell Enrichment for FISH: A Novel Diagnostic Tool in Challenging Cases of Low Bone Marrow Involvement By Mature B-Cell Neoplasms
Authors: Farzad Nooraie, J. Dianne Keen-Kim, Derek Denton Lyle, Shannon Dingivan, Austin Mauch, Kyle Lynes, Rene Castillo, David Kolker, Erik Cancino
Journal: Blood (2014)
FRI0132 Lipid Management among Individuals with Inflammatory Arthritis in The National Reasons for Geographic and Racial Differences in Stroke Cohort
Authors: I. Navarro-Millan, C. Gamboa, J.R. Curtis, M.M. Safford
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Cardiovascular (CVD) risk factor management may be suboptimal in people with inflammatory arthritis (IA) (rheumatoid arthritis [RA], psoriatic arthritis [PsA], ankylosing spondylitis [AS]). <h3>Objectives</h3> We compared hyperlipidemia treatment of participants with and without IA, controlling for individual-level factors that influence health services utilization. <h3>Methods</h3> The REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort includes 30,239 community dwelling black and white adults from the 48 contiguous US states recruited between 2003–7 and assessed with a telephone survey and in-home visit that included a blood draw and pill bottle review.<sup>1</sup> IA was identified through medications specific to autoimmune disease. Individuals with IA (without diabetes or hypertension) were compared to those with diabetes (but no IA), hypertension (but no diabetes or IA), or IA, diabetes, or hypertension. Logistic regression models examined odds of treatment among those with hyperlipidemia after accounting for predisposing, enabling, and need factors guided by Andersen and Aday9s model.<sup>2</sup> <h3>Results</h3> IA participants were younger and predominately women, with lower Framingham risk scores, and lower functional status (Table 1). Proportionately fewer IA patients were treated than others (Figure 1). The fully adjusted odds of treatment for those with IA were 27% lower but not significantly different from those without IA, hypertension, or diabetes. Participants with diabetes and HTN were 2-times more likely to be managed for hyperlipidemia than those without IA, diabetes, or hypertension. <h3>Conclusions</h3> In this study, hyperlipidemic participants with IA were less likely to be treated for hyperlipidemia than participants with diabetes or hypertension - diseases well known to increase CVD risk – even after accounting for levels of CVD risk. This study was limited by power. If confirmed in larger samples, these results reflect a potential gap in the management of hyperlipidemia for IA patients. <h3>References</h3> Howard VJ, Cushman M, Pulley L, et al. The reasons for geographic and racial differences in stroke study: objectives and design. Neuroepidemiology. 2005;25(3):135–143. Aday LA, Andersen R. A framework for the study of access to medical care. Health services research. Fall 1974;9(3):208–220. <h3>Acknowledgement</h3> A full list of participating REGARDS investigators and institutions can be found at http://www.regardsstudy.org. <h3>Disclosure of Interest</h3> None declared
The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin
Authors: Takanori Hidaka, Eisaku Ogawa, Eri H Kobayashi, Takafumi Suzuki, Ryo Funayama, Takeshi Nagashima, Taku Fujimura, Setsuya Aiba, Keiko Nakayama, Ryuhei Okuyama, Masayuki Yamamoto
Journal: Nature Immunology (2016)