tbuckley/cabot-search huggingface dataset:
FRI0119 Diclofenac Use and Risk of Myocardial Infarction in Spondyloarthropathy Patients: Table 1.
Authors: M. Dubreuil, Q. Louie-Gao, C. Peloquin, T. Neogi, Y. Zhang, H.K. Choi
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Ankylosing spondylyitis (AS) and Psoriatic arthritis (PsA) have been associated with increased risk of myocardial infarction (MI). Diclofenac use has been associated with MI in the general population and is commonly used in spondyloarthropathy (SpA) patients. However data on risk of MI with diclofenac use in the SpA population are not available. <h3>Objectives</h3> To examine the relation between diclofenac use and the risk of MI among SpA patients. <h3>Methods</h3> Using 1995-2012 data from The Health Improvement Network, a database of medical records from general practitioners in the United Kingdom, we identified patients with incident AS or PsA who had no history of ischemic heart disease or MI. Eligibility criteria included age 18-89 years, &gt;1 year enrollment in THIN prior to SpA diagnosis, and ≥1 prescription for an NSAID (never users excluded to minimize confounding by indication). We identified subjects prescribed diclofenac after SpA diagnosis and generated a diclofenac-exposed cohort. We selected subjects who were not currently exposed to diclofenac for inclusion in the comparator cohort. We used Cox proportional hazards regression models to calculate multivariable-adjusted hazard ratios (HRs) for incident MI. We conducted the equivalent cohort analyses for naproxen users (a negative control) and rofecoxib users (a positive control). <h3>Results</h3> Among individuals with incident AS or PsA, we identified 3480, 2176, and 527 incident users of diclofenac, naproxen and rofecoxib, respectively. Within the 3 cohorts studied, AS was present in 28-32% and 44-49% of all subjects were female. Crude incidence rate ratios for MI were 1.25 (0.86, 1.84) in the diclofenac cohort, 1.20 (0.78, 1.85) in the naproxen cohort, and 2.34 (1.24, 4.43) in the rofecoxib cohort relative to non-use. After multivariable adjustment, the hazard ratio for MI was 1.61 (1.08, 2.40) for diclofenac, 1.40 (0.90, 2.19) for naproxen, and 2.60 (1.30, 5.22) for rofecoxib (Table) compared with non-use. Restriction to AS subjects led to similar effect estimates, but did not reach statistical significance due to small numbers. <h3>Conclusions</h3> Diclofenac use among SpA patients was associated with a 61% increased risk of MI relative to non-use, while naproxen use was not associated with increased risk. Diclofenac use in persons with AS or PsA may increase MI risk beyond that associated with the underlying inflammatory disease. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1665
770 THE HCV NS3/4A-MEDIATED IMPAIRMENT OF THE HEPATIC ANTIVIRAL IMMUNE RESPONSE IS REVERSED BY PROTEASE INHIBITION OR RIBAVIRIN IN VIVO
Authors: E.D. Brenndörfer, A. Brass, J. Söderholm, L. Frelin, J.G. Bode, M. Sällberg
Journal: Journal of Hepatology (2012)
An Epidemiologic Study of Bacteriuria and Blood Pressure among Nuns and Working Women
Authors: Calvin M. Kunin, Regina C. McCormack
Journal: New England Journal of Medicine (1968)

To study the relation between urinary-tract infection and blood pressure, the frequency of these disorders was determined in two populations. In 2302 white working women, bacteriuria was, for successive twenty-year age periods, 12.8, 2.8 and 1.4 times higher than in 2882 white nuns. In Negro women, the differences were even greater. In white working women, the prevalence of bacteriuria was not significantly affected by number of pregnancies, form of menstrual protection or the use of oral contraceptives. Both systolic and diastolic blood pressure were lower for all ages among nuns than controls, findings not explainable by differences in body weight or use of oral contraceptives. Bacteriuric as compared to nonbacteriuric women had higher systolic blood pressures, but differences were not significant. Although these observations support the notion that urinary-tract infections may have an effect on blood pressure, they do not prove that a causal relation exists. Other explanations, such as "way of life," may be involved.
Tc-99m Phytate Images in a Patient With a Wandering Spleen
Authors: HITOYA OHTA, MIHO NISHIMURA, MASAHIKO NII, AKINARI NOMURA, TETSUJI HANAFUSA, MINORU UKIKUSA, HIROJI AWANE
Journal: Clinical Nuclear Medicine (1999)

Wandering spleen is a rare diagnosis, especially in children. Tc-99m phytate scintigraphy in the supine and upright positions was useful in the evaluation of wandering spleen in a 10-year-old girl.
The Urticaria Severity Score May Serve As An Early Clinical Indicator In Monitoring Patients With Chronic Urticaria
Authors: D.E. Ferastraoaru, S. Jariwala, E. Lobell, P. Parikh, P. Walters, M. Altrich, G. Hudes, D. Rosenstreich
Journal: Journal of Allergy and Clinical Immunology (2012)
Assessment of Potential Cancer Risk from Consumption of PCBs Bioaccumulated in Fish and Shellfish.
Authors: MG Barron, JJ Yurk, DB Crothers
Journal: Environmental Health Perspectives (1994)

We evaluated the potential cancer risk to adults from ingesting polychlorinated biphenyls (PCBs) in fish and shellfish using an equilibrium partitioning model of PCB bioaccumulation in the aquatic animal. Estimated potential cancer risk to humans increased exponentially with increasing hydrophobicity of the PCB. However, the addition of food-chain sources of PCBs was necessary to cause potential cancer risk to exceed 10(-6). Environmental degradation of the PCB reduced cancer risk by reducing the exposure concentration; 3.3 degradation half-lives were required to reduce cancer risk estimates by one order of magnitude. PCB biotransformation to nongenotoxic metabolites (no increase in the cancer slope factor) by the aquatic animal reduced cancer risk by reducing the steady-state concentration of PCBs in the edible tissue. Even relatively slow biotransformation (e.g., metabolic half-life of 100 days) reduced cancer risk estimates under the default model conditions. Nonequilibrium conditions, such as limited exposure time, reduced potential cancer risk by reducing contaminant concentrations in the aquatic animal. Risk assessment using toxic equivalency factors predicted substantially greater potential risk for specific congeners than for PCB mixtures. Our evaluation demonstrates that deviation from conventional assumptions used in risk assessment (e.g., negligible biotransformation and degradation; steady-state equilibrium) can significantly affect cancer risk estimates.
CHANGE OF P-WAVE AXIS PREDICTS GOOD CLINICAL OUTCOME AFTER ANTERIOR LINEAR ABLATION FOR LONGSTANDING PERSISTENT ATRIAL FIBRILLATION
Authors: Dong Geum Shin, Tae-Hoon Kim, Jae-Sun Uhm, Jong-Youn Kim, Boyoung Joung, Moon-Hyoung Lee, Hui-Nam Pak
Journal: Journal of the American College of Cardiology (2016)
826 NORDIHYDROGUAIARETIC ACID (NDGA) AND ITS TETRA-O-METHYL DERIVATIVE (M4N) EXHIBIT POTENT ANTI HEPATITIS C VIRUS (HCV) ACTIVITY AND SYNGERY WITH OTHER ANTIVIRALS
Authors: N.A. Chin, K.A. Jones, G. Syed, A. Siddiqui, D.L. Wyles
Journal: Journal of Hepatology (2012)
PO69THE IMPACT OF MGMT METHYLATION AND IDH-1 MUTATION ON LONG TERM OUTCOME FOR GLIOBLASTOMA TREATED WITH CHEMORADIOTHERAPY
Authors: Christopher P. Millward, Andrew R. Brodbelt, Brian Haylock, David Husband, Aditya Shenoy, Helen Wong, Michael D. Jenkinson
Journal: Neuro-Oncology (2015)

Background
Increasingly, biomarkers have been identified that correlate with improved overall and progression-free survival (OS and PFS) in glioblastoma, including MGMT methylation status and mutations in the IDH1 gene. In this study, we investigated the clinical and biological factors associated with long-term survival in glioblastoma patients treated with chemoradiotherapy.
A one-to-one training program would be valuable in learning how to perform esophageal endoscopic mucosal resection
Authors: J. Mannath, K. Ragunath
Journal: Endoscopy (2012)

We read the article by van Vilsteren et al. [1] with interest. The training program they describe is a well designed and structured approach to learning the complex procedure of esophageal endoscopic mucosal resection (EMR). This would provide guidance to endoscopists from other countries in designing such a training program. The authors conclude that there was a 5 % perforation rate in the first 120 cases in total performed by six trainees. We do agree that performance of 20 EMRs is probably inadequate for reaching the plateau of the learning curve, mainly because of the complexity of the procedure.
ABNORMAL RIGHT ATRIAL PERFORMANCE IN SURGICALLY REPAIRED TETRALOGY OF FALLOT: GERMAN COMPETENCE NETWORK FOR CONGENITAL HEART DEFECTS INVESTIGATORS
Authors: Shelby Kutty, Quanliang Shang, Shivani Patel, David Danford, Michael Steinmetz, Andreas Schuster, Titus Kuehne, Philipp Beerbaum, Samir Sarikouch
Journal: Journal of the American College of Cardiology (2015)
[PAH Cleanup in Illinois]: Response
Authors: Peter K. LaGoy
Journal: Environmental Health Perspectives (1994)

ResponseJames O'Brien of the Illinois EPA correctly points out an error in Table 1 of our arti- cle, namely, that the Illinois 1991 Leaking Underground Storage Tank Manual lists different allowable detection limits (ADLs) for each individual PAH.The ADLs used by Illinois range from 0.0087 mg/kg for benzo[a]anthracene (the source of the value of 0.009 mg/kg used in our table) to 0.100 mg/kg for chrysene.O'Brien also notes that Illinois published an updated version of this manual which lists the same ADLs but presents soil cleanup objectives for individual PAHs rather than the single value of 0.004 mg/kg for total carcinogenic PAHs listed in the 1991 document.The cleanup objectives are of two types, type A for soils that pose a threat to groundwater and type B for soils with a low potential for causing groundwater contamination.The type A objectives range from 0.0026 mg/kg for benzo[a]anthracene to 0.03 mg/kg for chrysene, and the type B objec- tives range from 0.013 for benzo[a]anthracene to 0.15 mg/kg for chrysene.O'Brien also noted that a regulatory proceeding current- ly before the Illinois Pollution Control Board may affect the 1993 soil objectives.We appreciate O'Brien's correction and clarification to our article.
Reply to Heresbach &amp; Pienkowski
Authors: Cesare Hassan
Journal: Endoscopy (2014)

We read with great interest the letter from Heresbach & Pienkowski on the recent French recommendations for post-polypectomy endoscopic surveillance [1] [2]. We agree with the authors that the main differences between the latter and the recent guidelines from the European Society of Gastrointestinal Endoscopy (ESGE) are represented by the surveillance interval for the low-risk group and – to a lesser extent – by the inclusion of patients with villous histology in the high risk group [2] [3].
NCI Still Has "Designs" on Food Chemical Research
Authors: F. Pollner
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article NCI Still Has “Designs” on Food Chemical Research Get access Fran Pollner Fran Pollner Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 22, 18 November 1992, Pages 1690–1691, https://doi.org/10.1093/jnci/84.22.1690 Published: 18 November 1992
IMPACT OF SHORTER DOOR TO BALLOON TIME ON LEFT VENTRICULAR EJECTION FRACTION IN STEMI PATIENTS WHO PRESENT EARLY TO HOSPITAL
Authors: Razvan Tudor Dadu, Mostafa El-Refai, Ana Davis, Jaromir Bobek, I-Hui Chiang, Mahboob Alam, Nasser Lakkis
Journal: Journal of the American College of Cardiology (2016)
Abstract 928: Species and cell type independent core MYC target genes in cancer and stem cells
Authors: Hongkai Ji, George Wu, Xiangcan Zhan, Alexandra Nolan, Cheryl Koh, Angelo De Marzo, Jinshui Fan, Chris Cheadle, Mohammad Fallahi, John Cleveland, Chi V. Dang, Karen Zeller
Journal: Cancer Research (2011)

Abstract The c-Myc (hereafter Myc) transcription factor augments the induction of pluripotency of somatic cells and contributes to human tumorigenesis, but the mechanisms by which Myc mediates these phenotypes remain only partially understood. To decipher Myc's biological functions, it is essential to define its target genes. To date, numerous Myc target gene lists have been constructed in various cellular contexts from several species but no study has rigorously defined species and cell type independent core Myc targets. Using a model of human B lymphoma cells bearing inducible MYC, we identified direct Myc target genes via chromatin immunoprecipitation (ChIP), global nuclear run-on assay, and changes in mRNA levels. We also identified, for the first time, direct Myc targets in human embryonic stem cells (ESCs). Here we report that Myc regulates a core set of target genes that are shared in mouse and human ESCs as well as in four other human cancer cell types. The expression of this gene set is increased in Myc-expressing premalignant B lymphocytes and is highly elevated in lymphoma cells from Eμ-Myc transgenic mice. Remarkably, the expression of the core gene set significantly correlates with MYC expression across 8,129 microarray samples in Gene Expression Omnibus (GEO), which represent 312 cell and tissue types. Expression profiles of B cell lymphomas, acute leukemia, lung cancers and Ewing sarcomas are among those with the highest correlation. Annotation of this gene signature highlights Myc's primordial function in ribosomal biogenesis as one of its key roles in cancer and stem cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 928. doi:10.1158/1538-7445.AM2011-928
Abstract 5011: Potential tumor suppressor role of PHD2 : functional study of mutations identified in germline DNA of patients with congenital polycythemia with or without paraganglioma
Authors: Betty Gardie, Charline Ladroue, Romain Carcenac, Sophie Gad, Michel Barrois, Johny Bombled, Olivier Hermine, Michel Leporrier, André Baruchel, Kiladjian Jean-Claude, Sophie Giraud, Nathalie Mazure, Jacques Pouyssegur, Stéphane Richard
Journal: Cancer Research (2010)

Abstract The Hypoxia Inducible Factor (HIF) plays a major role in tissue response to hypoxia. HIF induces expression of many genes involved in anaerobic glycolysis, angiogenesis, erythropoiesis and cell proliferation. HIF-alpha subunit is tightly regulated by a family of specific hydroxylases in normoxia. PHD (prolyl-hydroxylase domain) proteins hydroxylate HIF-alpha, thereby allowing its attachment to the VHL protein, a component of an E3 ubiquitin ligase complex involved in protein ubiquitination and degradation. Mutations in HIF regulators have been described and lead to the stabilization of HIF, activation of target genes and development of either tumors or polycythemia. Heterozygous germline mutations in the VHL gene predispose to the von Hippel-Lindau disease characterized by a panel of highly vascularized tumors (central nervous system and retinal hemangioblastomas, pheochromocytomas, renal cell carcinoma, pancreatic endocrine tumors) whereas homozygous or compound heterozygous VHL mutations are responsible for isolated polycythemia (”Chuvash polycythemia”) with high circulating erythropoietin levels. Recently, heterozygous germline mutations in the PHD2 gene have been described in few patients with such congenital polycythemia and a particular mutation (H374R) has been identified in a patient with a polycythemia and a recurrent paraganglioma1. This observation raised the question of a possible role of PHD2 loss of function in the genesis of tumors usually seen in the VHL disease. We report here four new heterozygous PHD2 germline mutations in patients with familial or apparently sporadic polycythemia. We performed a functional study of these mutants compared to the H374R mutant and we showed differences in the capacity of the PHD2 mutants to downregulate HIF-alpha. These differences, tested in various conditions, are highly reproducible and suggest that there may be a genotype/phenotype correlation for the PHD2 mutants like the VHL mutants with their different ability to regulate HIF associated with different phenotypes in the VHL disease. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5011.
Pulmonary Surfactant Therapy
Authors: A H Jobe
Journal: New England Journal of Medicine (1993)

In 1959, not long after surfactant had been identified as critical to maintaining lung inflation at low transpulmonary pressures,1,2 Avery and Mead3 reported that saline extracts from the lungs of preterm infants with respiratory distress syndrome lacked the low surface tension characteristic of pulmonary surfactant. After several unsuccessful attempts to treat infants with respiratory distress syndrome with aerosolized surfactant,4,5 intratracheal administration of surfactant recovered from the air spaces of mature animal lungs was found to improve lung expansion and ventilation in preterm animals68. The clinical potential of surfactant treatment for respiratory distress syndrome was demonstrated by . . .
Abstract LB-259: Arid1a loss in collaboration with PI3K pathway activation leads to ovarian tumorigenesis in mouse.
Authors: Bin Guan, Tian-Li Wang, Ie-Ming Shih
Journal: Cancer Research (2013)

Abstract ARID1A encoding BAF250a is a recently identified tumor suppressor involved in chromatin remodeling. Inactivating somatic mutations occur in a wide variety of human cancers including ovarian carcinoma. Interestingly, ARID1A mutations significantly co-occur with either PIK3CA or PTEN mutations in human neoplastic tissues, suggesting a molecular collaboration of ARID1A and PI3K/PTEN pathways in tumor development. We tested this possibility in Arid1a knockout mice (n=10) and Arid1a/Pten double knockout mice (n= 12), in which Arid1a and Pten can be conditionally deleted in the mouse ovarian surface epithelium (OSE) by intra-ovarian bursal injection of Ad-Cre virus. Arid1a knockout mice did not develop discernable histopathological changes 12 months after Ad-Cre administration in OSE, a finding similar to Pten knockout mice as reported previously. In contrast, Arid1a/Pten double knockout mice developed ovarian tumors in 40% mice 6 months after Ad-Cre virus injection. The tumors effaced ovarian tissues, disseminated intraperitoneally and developed ascites. None of the tumors expressed detectable ARID1A and Pten immunoreactivity, while fibroblastic cells and OSE cells from control ovaries are positive for both markers. Although all the tumors appear poorly differentiated, 80% tumors were positive for cytokeratin 8, suggestive of an epithelial origin. The remaining 60% mice without grossly visible tumors showed hyperplasia of OSE in Ad-Cre treated ovaries but not in non-injected controls. The hyperplasia of OSE developed as early as 2 months after Ad-Cre administration. In summary, our results demonstrate that mutation of Arid1a requires a second hit to initiate tumorigenesis. Collaboration between Arid1a inactivation and PI3K/Pten pathway aberration is sufficient to induce OSE hyperplasia and to develop poorly differentiated carcinomas. Citation Format: Bin Guan, Tian-Li Wang, Ie-Ming Shih. Arid1a loss in collaboration with PI3K pathway activation leads to ovarian tumorigenesis in mouse. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-259. doi:10.1158/1538-7445.AM2013-LB-259
Endoscopic injection of autologous blood for bleeding gastroduodenal ulcers
Authors: A. Schneider, W. Schepp
Journal: Endoscopy (2011)

Endoscopic injection of diluted epinephrine and the application of endoclips or thermal probes are established endoscopic therapies for peptic ulcer bleeding (PUB). However, autologous blood may offer advantages at least over diluted epinephrine due to its specific properties: corpuscular components may provide prolonged persistence and procoagulatory constituents may additionally prevent recurrent bleeding. We performed successful endoscopic injection of autologous blood for acute spurting (Forrest Ia) or oozing (Ib) bleeding from duodenal or gastric ulcers. The injection of autologous blood was simple to apply and achieved hemostasis in bleeding Forrest I peptic ulcers. This technique can be considered as an adjunct or an alternative to other methods for endoscopic control of PUB.
Large deletions 5′ to the ETO breakpoint are recurrent events in patients with t(8;21) acute myeloid leukemia
Authors: C Godon, J Proffitt, N Dastugue, M Lafage-Pochitaloff, M-J Mozziconacci, P Talmant, M Hackbarth, R Bataille, H Avet-Loiseau
Journal: Leukemia (2002)
Perforation posterior to endoscopic band ligation of a gastric submucosal tumor
Authors: X. Xing, J. Wang, M. Chen, Y. Cui
Journal: Endoscopy (2012)

In a 45-year-old woman with epigastric discomfort for 1 year, upper gastrointestinal endoscopy and endoscopic ultrasonography (EUS) showed a hypoechoic solid mass originating from the muscularis propria of the posterior wall of the gastric fundus ([Fig. 1]). EUS revealed that this 0.8 × 0.6 cm mass was probably a gastrointestinal stromal tumor (GIST) because of its morphological characteristics; the tumor was growing towards the gastric lumen and was partly connected with the muscularis propria.
Abstract P5-03-08: Overexpression of AIB1 mRNA in Breast Cancer Inversely Correlates with Estrogen Receptor Positivity
Authors: A Lee, K Lee, BJ Chae, BJ Song, SS Jung, CS. Kang
Journal: Cancer Research (2010)

Abstract Background: The AIB1 is a steroid receptor coactivator that promotes the transcriptional activity of nuclear receptors such as estrogen receptor. It is overexpressed at the mRNA level in up to 60% of primary breast carcinomas. Methods: In situ hybridization to examine AIB1 mRNA expression was performed in 113 breast carcinomas in the Catholic university of Korea, from Jan. 2004 to Dec. 2008. We investigated the prognostic significance of AIB1 and the correlation of immunohistochemical staining results of estrogen receptor(ER), progesterone receptor (PR), and Her2/neu. Results: AIB1 mRNA overexpression showed in 55 of 113 (48.7%) breast carcinomas. AIB1 mRNA expression was significantly associated with T stage (P=0.002), but not associated with age, lymph node metastasis, histologic type and histologic grade. High expression of AIB1 mRNA was inversely correlated with expression of ER (P=0.011, R=-0.241) and not significantly associated, but also adversely related, with expression of PR (P=0.101, R=-0.157). AIB1 mRNA overexpression was associated with positivity of Her2/neu (P=0.001, R= 0.311). Survival and recurrent free analysis did not reveal significant association with AIB1 expression. Conclusion: AIB1 mRNA overexpression could be involved in breast cancer by mechanism not totally dependent on steroid receptor cofactor, and may involved other estrogen independent growth pathway such as Her2/neu expression. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-03-08.
A NOVEL THIN-STRUT SIROLIMUS-ELUTING BIORESORBABLE SCAFFOLD: PRECLINICAL EVALUATION IN PORCINE CORONARY ARTERIES UP TO 6 MONTHS
Authors: Yanping Cheng, Pawel Gasior, Gaoke Feng, Edward A. Estrada, Jennifer McGregor, Kamal Ramzipoor, Chang Lee, Wang Lijie, Gerard Conditt, Serge Rousselle, Greg Kaluza, Juan Granada
Journal: Journal of the American College of Cardiology (2016)