FRI0225 Presence of fibromyalgia and fatigue is not increased in patients with takayasu’s arteritis:
Authors: F. Alibaz-Oner, M. Can, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Takayasu’s arteritis (TA) is a chronic inflammatory large-vessel vasculitis of the aorta and its major branches. To our knowledge, there is no data about the frequency of Fibromyalgia Syndrome (FM), a systemic pain disorder, in TA. <h3>Objectives</h3> We aimed to investigate the frequency of FMS in TA defined according to the 2010 ACR Preliminary Diagnostic Criteria for FM. The correlation between ACR-1990 and 2010 FM criterias and the effect of patient-reported outcomes (PROs) such as Health Assessment Questionnaire (HAQ), Multidimensional Assessment of Fatigue Scale (MAF), <i>Short-Form 36</i>-item survey (<i>SF-36</i>) and anxiety and depression scales on FM were also analysed. <h3>Methods</h3> We studied 42 patients with TA (F/M: 38/4, mean age: 30.8 years) and 20 (F/M: 11/9, mean age:32.8 years) healthy controls (HC). Fourteen patients (33,3%) were clinically active. All patients were examined for FM tender points (ACR 1990 criteria for classification for FM) by two observer (kappa: 0.648) and asked to complete new ACR 2010 FM questionnaire for FM (ref1). PROs were used to assess quality of life together with HAQ. <h3>Results</h3> Seven (16.6%) TA patients and 3 HC (15%) met the ACR-2010 FM criteria, whereas only 3 (7,1%) patients and no controls (0%) met the 1990 Criteria. No significant differences regarding the FM frequency were present according to both ACR-2010 and 1990 FM criterias between TA and HC. No differences were also observed for the 2 subscales of 2010 criteria, the Widespread Pain Index (WPI) and the Symptom Severity (SS) scale among the groups. FM presence was also similar between active and inactive patients (p:0,143).The SF-36 physical component score (PCS) were significantly lower [TA:45,85 (18-62), HC: 55,5 (31-59), p=0.009] and HAQ score significantly higher in patients with TA [0,175 (0- 2,35)]compared to HC[0,005 (0-0,45)] (p&lt;0,001). No differences were present in other PROs (Table 1). WPI correlate significantly with tender points (r=0,728, p&lt;0,001), MAF (r=0,692, p&lt;0,001), HAQ (r=0,539, p&lt;0,001), anxiety (r=0,442, p&lt;0,001), depression (r=0,475, p&lt;0,001), PCS (r= -0,629, p&lt;0,001) and MCS (r=-0, 468, p&lt;0,001). SSS correlate significantly with tender points (r=0,508, p&lt;0,001), MAF (r=0,773, p&lt;0,001), HAQ (r=0,4999, p&lt;0,001), anxiety (r=0,618, p&lt;0,001), depression (r=0,498, p&lt;0,001), PCS (r= -0,617, p&lt;0,001) and MCS (r=-0,629, p&lt;0,001). <h3>Conclusions</h3> The frequency of FM is similar to general population in patients with Takayasu arteritis. The new ACR-2010 FM criteria seem to be more sensitive than the ACR-1990 criteria for diagnosis. Although other PROs also does not differ from HC, the new FM criteria subscales WPI and SSS significantly correlated with scales such as SF-36, MAF, anxiety and depression scale and HAQ in TA, suggesting that in a minority of patients with FM and TA, PROs are affected with FM presence. <h3>References</h3> Wolfe F, Clauw DJ, Fitzcharles MA, et al. The ACR preliminary diagnostic criteria forfibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken). 2010 May;62(5):600-10. <h3>Disclosure of Interest</h3> None Declared