tbuckley/cabot-search huggingface dataset:
Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy
Authors: Nigel A. Calcutt, Darrell R. Smith, Katie Frizzi, Mohammad Golam Sabbir, Subir K. Roy Chowdhury, Teresa Mixcoatl-Zecuatl, Ali Saleh, Nabeel Muttalib, Randy Van der Ploeg, Joseline Ochoa, Allison Gopaul, Lori Tessler, Jürgen Wess, Corinne G. Jolivalt, Paul Fernyhough
Journal: Journal of Clinical Investigation (2017)

Sensory neurons have the capacity to produce, release, and respond to acetylcholine (ACh), but the functional role of cholinergic systems in adult mammalian peripheral sensory nerves has not been established. Here, we have reported that neurite outgrowth from adult sensory neurons that were maintained under subsaturating neurotrophic factor conditions operates under cholinergic constraint that is mediated by muscarinic receptor-dependent regulation of mitochondrial function via AMPK. Sensory neurons from mice lacking the muscarinic ACh type 1 receptor (M1R) exhibited enhanced neurite outgrowth, confirming the role of M1R in tonic suppression of axonal plasticity. M1R-deficient mice made diabetic with streptozotocin were protected from physiological and structural indices of sensory neuropathy. Pharmacological blockade of M1R using specific or selective antagonists, pirenzepine, VU0255035, or muscarinic toxin 7 (MT7) activated AMPK and overcame diabetes-induced mitochondrial dysfunction in vitro and in vivo. These antimuscarinic drugs prevented or reversed indices of peripheral neuropathy, such as depletion of sensory nerve terminals, thermal hypoalgesia, and nerve conduction slowing in diverse rodent models of diabetes. Pirenzepine and MT7 also prevented peripheral neuropathy induced by the chemotherapeutic agents dichloroacetate and paclitaxel or HIV envelope protein gp120. As a variety of antimuscarinic drugs are approved for clinical use against other conditions, prompt translation of this therapeutic approach to clinical trials is feasible.
Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis
Authors: Moitza Principe, Simone Borgoni, Mariafrancesca Cascione, Michelle Samuel Chattaragada, Sammy Ferri-Borgogno, Michela Capello, Sara Bulfamante, Jennifer Chapelle, Francesca Di Modugno, Paola Defilippi, Paola Nisticò, Paola Cappello, Chiara Riganti, Stefano Leporatti, Francesco Novelli
Journal: Journal of Hematology & Oncology (2017)

We have previously shown that in pancreatic ductal adenocarcinoma (PDA) cells, the glycolytic enzyme alpha-enolase (ENO1) also acts as a plasminogen receptor and promotes invasion and metastasis formation. Moreover, ENO1 silencing in PDA cells induces oxidative stress, senescence and profoundly modifies PDA cell metabolism. Although anti-ENO1 antibody inhibits PDA cell migration and invasion, little is known about the role of ENO1 in regulating cell-cell and cell-matrix contacts. We therefore investigated the effect of ENO1 silencing on the modulation of cell morphology, adhesion to matrix substrates, cell invasiveness, and metastatic ability. The membrane and cytoskeleton modifications that occurred in ENO1-silenced (shENO1) PDA cells were investigated by a combination of confocal microscopy and atomic force microscopy (AFM). The effect of ENO1 silencing was then evaluated by phenotypic and functional experiments to identify the role of ENO1 in adhesion, migration, and invasion, as well as in senescence and apoptosis. The experimental results were then validated in a mouse model. We observed a significant increase in the roughness of the cell membrane due to ENO1 silencing, a feature associated with an impaired ability to migrate and invade, along with a significant downregulation of proteins involved in cell-cell and cell-matrix adhesion, including alpha v/beta 3 integrin in shENO1 PDA cells. These changes impaired the ability of shENO1 cells to adhere to Collagen I and IV and Fibronectin and caused an increase in RGD-independent adhesion to vitronectin (VN) via urokinase plasminogen activator receptor (uPAR). Binding of uPAR to VN triggers integrin-mediated signals, which result in ERK1-2 and RAC activation, accumulation of ROS, and senescence. In shENO1 cancer cells, the use of an anti-uPAR antibody caused significant reduction of ROS production and senescence. Overall, a decrease of in vitro and in vivo cell migration and invasion of shENO1 PDA cells was observed. These data demonstrate that ENO1 promotes PDA survival, migration, and metastasis through cooperation with integrins and uPAR.
Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53 -Driven Lung Adenocarcinoma
Authors: Verline Justilien, Syed A. Ali, Lee Jamieson, Ning Yin, Adrienne D. Cox, Channing J. Der, Nicole R. Murray, Alan P. Fields
Journal: Cancer Cell (2017)

The guanine nucleotide exchange factor (GEF) epithelial cell transforming sequence 2 (Ect2) has been implicated in cancer. However, it is not clear how Ect2 causes transformation and whether Ect2 is necessary for tumorigenesis in vivo. Here, we demonstrate that nuclear Ect2 GEF activity is required for Kras-Trp53 lung tumorigenesis in vivo and that Ect2-mediated transformation requires Ect2-dependent rDNA transcription. Ect2 activates rRNA synthesis by binding the nucleolar transcription factor upstream binding factor 1 (UBF1) on rDNA promoters and recruiting Rac1 and its downstream effector nucleophosmin (NPM) to rDNA. Protein kinase Cι (PKCι)-mediated Ect2 phosphorylation stimulates Ect2-dependent rDNA transcription. Thus, Ect2 regulates rRNA synthesis through a PKCι-Ect2-Rac1-NPM signaling axis that is required for lung tumorigenesis.
Obamacare repeal could leave 32 million uninsured and double premiums, report finds
Authors: Michael McCarthy
Journal: BMJ (2017)

A Republican bill repealing portions of the Affordable Care Act would increase the number of people without insurance in the US by 18 million and increase premiums for individual health insurance policies by as much as 25% in the first year of its enactment, a study by the Congressional Budget Office (CBO) concludes.1

In subsequent years, as provisions of the bill came into effect eliminating the law’s expansion of Medicaid eligibility and subsidies for insurance purchased on health insurance exchanges, the number of people without insurance would rise to 27 million and eventually reach 32 million by 2026, the report said. Premiums for individual plans would also climb, rising …
A novel PTPN1 splice variant upregulates JAK/STAT activity in classical Hodgkin lymphoma cells
Authors: Malena Zahn, Ralf Marienfeld, Ingo Melzner, Janine Heinrich, Benjamin Renner, Silke Wegener, Anna Mießner, Thomas F. E. Barth, Karola Dorsch, Silke Brüderlein, Peter Möller
Journal: Blood (2017)
Safety and Efficacy of Azacitidine in Myelodysplastic Syndrome (MDS) Patients with Mild and Moderate Renal Impairment
Authors: Evdoxia Douvali, Menelaos Papoutselis, Emmanuil Spanoudakis, Eleytherios Moustakides, Emilia Tsakiroglou, Konstantinos Tsatalas, Ioannis Kotsianidis
Journal: Blood (2012)
AF Ablation Guided by Spatiotemporal Electrogram Dispersion Without Pulmonary Vein Isolation
Authors: Julien Seitz, Clément Bars, Guillaume Théodore, Sylvain Beurtheret, Nicolas Lellouche, Michel Bremondy, Ange Ferracci, Jacques Faure, Guillaume Penaranda, Masatoshi Yamazaki, Uma Mahesh R. Avula, Laurence Curel, Sabrina Siame, Omer Berenfeld, André Pisapia, Jérôme Kalifa
Journal: Journal of the American College of Cardiology (2017)
Phase 2 Study of FLAGM (Fludarabine+High-Dose Ara-C +G-CSF+Mitoxantrone) for Relapsed or Refractory Acute Myeloid Leukemia (AML): A Report From the Japan Adult Leukemia Study Group (JALSG).
Authors: Shuichi Miyawaki, Naoko Hatsumi, Takahiro Yamauchi, Kousuke Tsuboi, Atsushi Fujieda, Akihiro Takeshita, Norio Komatsu, Noriko Usui, Yukihiro Arai, Fumihiro Ishida, Takeshi Morii, Yasuhiko Kano, Michinori Ogura, Noriko Doki, Kazunori Ohnishi, Tomoki Naoe, Ryuzo Ohno
Journal: Blood (2009)
Shorter Telomeres Are Associated with the Unfavourable Chromosomal Aberrations Del 17p and Del 11q in Chronic Lymphocytic Leukemia (CLL)
Authors: Ludger Sellmann, Dirk de Beer, Marius Bartels, Holger Nueckel, Ulrich Duehrsen, Jan Duerig, Gabriela Baerlocher, Alexander Roeth
Journal: Blood (2008)
Patients with Chronic Myeloid Leukemia Show Different Modulation of MYB-Dependent Oncogenic Pathway in the Course of Hematopoietic Differentiation upon Sensitivity to the TKI Treatment
Authors: Klara Srutova, Nikola Curik, Koblihova Jitka, Filipp Savvulidi, Hana Klamova, Danilo Perrotti, Tomas Stopka, Katerina Machova Polakova
Journal: Blood (2015)
Pharmacokinetics of Obinutuzumab (GA101) in Patients with CD20+ Relapsed/Refractory Malignant Disease Receiving Concomitant Chemotherapy (Phase Ib Study BO21000),
Authors: David Carlile, Georgina Meneses-Lorente, Elisabeth Wassner-Fritsch, Florence Hourcade-Potelleret, Michael K. Wenger, Guillaume Cartron, Umberto Vitolo, John Radford, Andrew Davies, Franck Morschhauser
Journal: Blood (2011)
The fingerprint of antimitochondrial antibodies and the etiology of primary biliary cholangitis
Authors: Zongwen Shuai, Jinjun Wang, Madhu Badamagunta, Jinjung Choi, Guoxiang Yang, Weici Zhang, Thomas P. Kenny, Kathryn Guggenheim, Mark J. Kurth, Aftab A. Ansari, John Voss, Ross L. Coppel, Pietro Invernizzi, Patrick S.C. Leung, M. Eric Gershwin
Journal: Hepatology (2017)

The identification of environmental factors that lead to loss of tolerance has been coined the holy grail of autoimmunity. Our work has focused on the reactivity of antimitochondrial autoantibodies (AMA) to chemical xenobiotics and has hypothesized that a modified peptide within PDC‐E2, the major mitochondrial autoantigen, will have been immunologically recognized at the time of loss of tolerance. Herein, we successfully applied intein technology to construct a PDC‐E2 protein fragment containing amino acid residues 177‐314 of PDC‐E2 by joining a recombinant peptide spanning residues 177‐252 (PDC‐228) with a 62‐residue synthetic peptide from 253 to 314 (PP), which encompasses PDC‐E2 inner lipoyl domain (ILD). We named this intein‐constructed fragment PPL. Importantly, PPL, as well as lipoic acid conjugated PPL (LA‐PPL) and xenobiotic 2‐octynoic acid conjugated PPL (2OA‐PPL), are recognized by AMA. Of great importance, AMA has specificity for the 2OA‐modified PDC‐E2 ILD peptide backbone distinct from antibodies that react with native lipoylated PDC‐E2 peptide. Interestingly, this unique AMA subfraction is of the immunoglobulin M isotype and more dominant in early‐stage primary biliary cholangitis (PBC), suggesting that exposure to 2OA‐PPL‐like compounds occurs early in the generation of AMA. To understand the structural basis of this differential recognition, we analyzed PPL, LA‐PPL, and 2OA‐PPL using electron paramagnetic resonance spectroscopy, with confirmations by enzyme‐linked immunosorbent assay, immunoblotting, and affinity antibody analysis. We demonstrate that the conformation of PDC‐E2 ILD is altered when conjugated with 2OA, compared to conjugation with lipoic acid. Conclusion : A molecular understanding of the conformation of xenobiotic‐modified PDC‐E2 is critical for understanding xenobiotic modification and loss of tolerance in PBC with widespread implications for a role of environmental chemicals in the induction of autoimmunity. (H epatology 2017;65:1670‐1682).
Controversial US guidelines raise systolic blood pressure limit for healthy over 60s
Authors: Michael McCarthy
Journal: BMJ (2017)

Pharmacologic treatment for hypertension should begin in otherwise healthy adults aged 60 years or older if they have persistent systolic blood pressure at or above 150 mm Hg with the goal of achieving a systolic blood pressure of less than 150 mm Hg, the American College of Physicians (ACP) and the American Academy of Family Physicians (AAFP) have said in new guidelines published in the Annals of Internal Medicine .1

“High quality evidence showed that treating hypertension in older adults to moderate targets (<150/90 mm Hg) …
Out-RANKing BRCA1 in Mutation Carriers
Authors: Emma Nolan, Geoffrey J. Lindeman, Jane E. Visvader
Journal: Cancer Research (2017)

Beyond prophylactic mastectomy, there are currently very few options available to BRCA1 mutation carriers to help reduce their risk of developing breast cancer. An effective prevention therapy therefore remains a pressing area of need. Accumulating evidence points to amplification of the progesterone signaling axis in precancerous tissue from BRCA1 mutation carriers. Given that RANKL is an important paracrine mediator of hormonal signaling in breast tissue, there has been considerable interest in exploring a potential role for this pathway in oncogenesis. Recent findings indicate that the RANK and NF-κB pathways are aberrantly activated in luminal progenitor cells resident in preneoplastic BRCA1mut/+ breast tissue. The augmented proliferation of these cells and their predilection for DNA damage suggest that they are prime cellular targets for basal-like cancers arising in BRCA1 mutation carriers. The end result is a hyperactive pathway, initiated by progesterone and amplified by DNA damage-induced NF-κB signaling, that likely accounts for the susceptibility of BRCA1mut/+ luminal progenitor cells to oncogenesis and tissue specificity. Specific targeting of this progenitor subset has revealed a compelling new prevention strategy for these and possibly other high-risk women. Cancer Res; 77(3); 595-600. ©2017 AACR.
Developing Novel Approaches To Comprehensively Assess T Cell Repertoire Dynamics In The Early Post-Transplant Period
Authors: Ute E. Burkhardt, Joseph Kaplinsky, Cindy Desmarais, Kristen E. Stevenson, Edwin P. Alyea, Robert J. Soiffer, Jerome Ritz, Donna S. Neuberg, Ramy Arnaout, Catherine J. Wu
Journal: Blood (2013)
Down Regulation of GATA-2 and the Inversely-Correlated Expression of Adipogenic Specific Gene-PPARγ in Mesenchymal Stem Cells from Patients with Aplastic Anemia.
Authors: Yinyan Xu, Yoshiyuki Takahashi, Yue Wang, Hirokazu Hidaka, Hiroshi Yagasaki, Seiji Kojima
Journal: Blood (2007)
Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine
Authors: Ameya R. Kirtane, Tanmoy Sadhukha, Hyunjoon Kim, Vidhi Khanna, Brenda Koniar, Jayanth Panyam
Journal: Cancer Research (2017)

Abstract Elevated interstitial fluid pressure and solid stress within tumors contribute to poor intratumoral distribution of nanomedicine. In this study, we hypothesized that the presence of fibrin in tumor extracellular matrix contributes to hindered intratumoral distribution of nanocarriers and that this can be overcome through the use of a fibrinolytic enzyme such as tissue plasminogen activator (tPA). Analysis of fibrin expression in human tumor biopsies showed significant fibrin staining in nearly all tumor types evaluated. However, staining was heterogeneous across and within tumor types. We determined the effect of fibrin on the diffusion, intratumoral distribution, and therapeutic efficacy of nanocarriers. Diffusivity of nanocarriers in fibrin matrices was limited and could be improved significantly by coincubation with tPA. In vivo, coadministration of tPA improved the anticancer efficacy of nanoparticle-encapsulated paclitaxel in subcutaneous syngeneic mouse melanoma and orthotopic xenograft lung cancer models. Furthermore, treatment with tPA led to decompression of blood vessels and improved tumor perfusion. Cotreatment with tPA resulted in greater intratumoral penetration of a model nanocarrier (Doxil), leading to enhanced availability of the drug in the tumor core. Fibrinolytics such as tPA are already approved for other indications. Fibrinolytic cotherapy is therefore a rapidly translatable strategy for improving therapeutic effectiveness of anticancer nanomedicine. Cancer Res; 77(6); 1465–75. ©2017 AACR.
Aberrant Microrna Expression In Chinese Patients with Chronic Lymphocytic Leukemia.
Authors: Danxia Zhu, Lei Fan, Cheng Fang, Dongmei Wang, Huajie Dong, Huayuan Zhu, Yun Zhuang, Kourong Miao, Peng Liu, Wei Xu, Jianyong Li
Journal: Blood (2010)
Multiclonal Diagnosis and MRD Follow-up in ALL with HTS Coupled with a Bioinformatic Analysis
Authors: Nathalie Grardel, Mikaël Salson, Aurélie Caillault, Marc Duez, Céline Villenet, Christophe Roumier, Martin Figeac, Brigitte Nelken, Bruno Quesnel, Claude Preudhomme, Mathieu Giraud
Journal: Blood (2014)
Enhanced Phosphorylation of Nbs1, a Member of the DNA Repair/Checkpoint Activation Complex Rad50/Mre11/Nbs1, Prolongs Cell Cycle S Phase and Contributes to Drug Resistance in BCR/ABL-Positive Leukemias.
Authors: Lori Rink, Tomasz Stoklosa, Tomasz Skorski
Journal: Blood (2005)
SNP12 and SNP13 Variants of NOD2/CARD15 Gene of Donor and Recipient as Independent Risk Factors for Severe Intestinal and Pulmonary GVHD after Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Alexandra Holowiecka-Goral, Jerzy Wojnar, Sebastian Giebel, Elzbieta Grudziecka, Malgorzata Oczko, Barbara Jarzab, Monika Sankowska
Journal: Blood (2006)
Assessment of p53 Functionality in Chronic Lymphocytic Leukemia by Different Assays; An Eric-Wide Approach.
Authors: Doreen te Raa, Jitka Malcikova, Marek Mraz, Sarka Pospisilova, Magali Le Garff-Tavernier, Helene Merle-Beral, Tatjana Stankovic, Marinus H. J. van Oers, Eric Eldering, Stephan Stilgenbauer, Thorsten Zenz, Arnon P. Kater
Journal: Blood (2012)
Loss of EZH2 and Aberrant DNA Methylation Account for PKC412 Drug Resistance in the FLT3-ITD Positive Acute Myeloid Leukemia (AML) Cell Line MV4-11,
Authors: Stefanie Göllner, Tino Schenk, Christian Rohde, Arthur Zelent, Friedrich Stölzel, Christian Thiede, Wolfgang E. Berdel, Carsten Müller-Tidow
Journal: Blood (2011)
Long Term Trends in Chronic Myeloid Leukemia (CML) Following the FDA Approval of Tyrosine Kinase Inhibitors (TKIs), on Bone Marrow Transplant Rates and Clinical Outcomes - a Study of the Nationwide Inpatient Sample Between 1998-2011
Authors: Parshva Patel, Indumathy Varadarajan, Gaurav Varma, Trotta Christina, Kristine Ward, Maneesh Jain, Michael Styler
Journal: Blood (2015)
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation
Authors: Claire Mazumdar, Ying Shen, Seethu Xavy, Feifei Zhao, Andreas Reinisch, Rui Li, Michael Ryan Corces-Zimmerman, Jason Buenrostro, Steven M. Chan, Daniel Thomas, Julie Koenig, Wan-Jen Hong, Howard Chang, Ravi Majeti
Journal: Blood (2015)
Influence of Platelet Depletion on Immunomagnetic CD34+ Cell Selection for Haploidentical Transplants.
Authors: Claudia Del Fante, Gianluca Viarengo, Paola Bergamaschi, Andrea Marchesi, Laura Bellotti, Cristina Parisi, Carmine Tinelli, Laura Salvaneschi, Cesare Perotti
Journal: Blood (2004)
FLVCRb: a Mitochondrial FLVCR Isoform Important for Erythropoiesis
Authors: Deborah Chiabrando, Sonia Mercurio, Samuele Marro, Sharmila Fagoonee, Erika Messana, Emilia Turco, Lorenzo Silengo, Fiorella Altruda, Emanuela Tolosano
Journal: Blood (2010)
Low Dose Alemtuzumab Achieves Long-Term Engraftment with Low Level Mixed Chimerism in Related Haemopoietic Stem Cell Transplantation for Haemoglobinopathies
Authors: Josu de la Fuente, Farah O’Boyle, Natalie Killeen, Allison Tso, Helen New, Ayad Atra, Inderjeet Dokal, Tom Vulliamy, John Davis, Letizia Foroni, Richard M. Szydlo, Irene Roberts
Journal: Blood (2008)
Expansion of Liver-Infiltrating CTL Clone In Concert with the Development of Hepatitis-Associated AA.
Authors: Yasuhiro Ikawa, Ryosei Nishimura, Shintaro Mase, Rie Kuroda, Raita Araki, Hideaki Maeba, Masaki Shimizu, Taizo Wada, Tomoko Toma, Shoichi Koizumi, Akihiro Yachie
Journal: Blood (2010)
Listeria monocytogenes isolation from urine: a series of 15 cases and review
Authors: F. Danion, M.M. Maury, A. Leclercq, A. Moura, V. Perronne, S. Léotard, M. Dary, B. Tanguy, H. Bracq-Dieye, P. Thouvenot, M. Lecuit, C. Charlier
Journal: Clinical Microbiology and Infection (2017)
Response to ‘Does inflammation predict radiographic progression in hand osteoarthritis?’ by Li<i>et al</i>
Authors: Alexander Mathiessen, Barbara Slatkowsky-Christensen, Tore K Kvien, Hilde Berner Hammer, Ida K Haugen
Journal: Annals of the Rheumatic Diseases (2017)

Dear Editor,

We highly appreciate the interest Li and Liu1 show in our paper in their eLetter.

The concern of Drs Li and Liu is the low number of patients with inflammation in our cohort, and they suggest carefulness when interpreting the results. Unfortunately, Li and Liu have misunderstood the results when stating that “synovitis and power Doppler were found only in 16.6% and 2.5% of the 78 included participants respectively”. These numbers are found in table 1 and refer to the number of affected joints , not patients. 2 The high prevalence of synovitis at patient level is reported in the Results section, second paragraph: ‘At baseline, …
Renal Cell Carcinoma with Isolated Lymph Node Involvement: Long-term Natural History and Predictors of Oncologic Outcomes Following Surgical Resection
Authors: Boris Gershman, Daniel M. Moreira, R. Houston Thompson, Stephen A. Boorjian, Christine M. Lohse, Brian A. Costello, John C. Cheville, Bradley C. Leibovich
Journal: European Urology (2017)
No association between the presence of killer-cell immunoglobulin-like receptor genes and susceptibility to childhood ALL
Authors: Lena Oevermann, Matthias Firnkorn, Sebastian Michaelis, Simon Müller, Elke Schaeffeler, Martin Schrappe, Gunnar Cario, Martin Stanulla, Matthias Schwab, Rupert Handgretinger, Markus Mezger
Journal: Blood (2015)
Factors Influencing Reconstitution of Mucosal-Associated Invariant T Cells Following Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Abir Bhattacharyya, David Fredricks, Sujatha Srinivasan, Martin T Morgan, Michael Boeckh, Steven A. Pergam, Tanya M Budiarto, Stanley R Riddell, Cameron J Turtle
Journal: Blood (2014)
Phase 1 Dose-Escalation/Expansion Study of the p38/Tie2 Inhibitor ARRY-614 in Patients with IPSS Low/Int-1 Risk Myelodysplastic Syndromes
Authors: Rami S. Komrokji, Alan F. List, H. Jean Khoury, Jeffrey E. Lancet, Elias Jabbour, Maria C Foudray, Shannon L Winski, Stacie Bell, Selena Armistead Rush, Lara Maloney, Ann Marie Ptaszynski, Hagop M. Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2011)
Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing
Authors: Rea M Lardelli, Ashleigh E Schaffer, Veerle R C Eggens, Maha S Zaki, Stephanie Grainger, Shashank Sathe, Eric L Van Nostrand, Zinayida Schlachetzki, Basak Rosti, Naiara Akizu, Eric Scott, Jennifer L Silhavy, Laura Dean Heckman, Rasim Ozgur Rosti, Esra Dikoglu, Anne Gregor, Alicia Guemez-Gamboa, Damir Musaev, Rohit Mande, Ari Widjaja, Tim L Shaw, Sebastian Markmiller, Isaac Marin-Valencia, Justin H Davies, Linda de Meirleir, Hulya Kayserili, Umut Altunoglu, Mary Louise Freckmann, Linda Warwick, David Chitayat, Susan Blaser, Ahmet Okay Çağlayan, Kaya Bilguvar, Huseyin Per, Christina Fagerberg, Henrik T Christesen, Maria Kibaek, Kimberly A Aldinger, David Manchester, Naomichi Matsumoto, Kazuhiro Muramatsu, Hirotomo Saitsu, Masaaki Shiina, Kazuhiro Ogata, Nicola Foulds, William B Dobyns, Neil C Chi, David Traver, Luigina Spaccini, Stefania Maria Bova, Stacey B Gabriel, Murat Gunel, Enza Maria Valente, Marie-Cecile Nassogne, Eric J Bennett, Gene W Yeo, Frank Baas, Jens Lykke-Andersen, Joseph G Gleeson
Journal: Nature Genetics (2017)
Hydroxyurea Induces Hepcidin Expression In Monocytes In Sickle Cell Anemia Patients
Authors: Kleber Yotsumoto Fertrin, Carolina Lanaro, Carla Fernanda Franco-Penteado, Dulcinéia Martins Albuquerque, Mariana R. B. Mello, Marcos André Cavalcanti Bezerra, Betania Lucena Borges Tavares Domingues, Sara T. Olalla-Saad, Aderson S. Araujo, Fernando Ferreira Costa
Journal: Blood (2010)
Autoimmune lymphoproliferative syndrome caused by homozygous FAS mutations with normal or residual protein expression
Authors: Nourhen Agrebi, Lamia Sfaihi Ben-Mansour, Moez Medhaffar, Sondes Hadiji, Faten Fedhila, Meriem Ben-Ali, Najla Mekki, Mongia Hachicha, Sihem Barsaoui, Mohamed-Ridha Barbouche, Imen Ben-Mustapha
Journal: Journal of Allergy and Clinical Immunology (2017)