tbuckley/cabot-search huggingface dataset:
AB0374 Postpartum Course Rheumatoid Arthritis and Mother's Breast Feeding Status
Authors: N. Kosheleva, E. Matianova, Z. Alekberova, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> It is known that pregnancy in rheumatoid arthritis (RA) patients has a beneficial effect on disease activity in 43-66% cases, but at the same time RA flares would hit up to 40-70% patients after delivery. However, the postpartum period is associated with breastfeeding, the importance of which for the mother and the child can not be overestimated. <h3>Objectives</h3> To evaluate the likelihood of breast-feeding in patients with RA. <h3>Methods</h3> It was a prospective study of 32 cases of postpartum course of the disease in 29 women with documented RA (ACR 1987), 10 of which had the juvenile onset of the disease. Patients were observed at V.A. Nasonova Research Institute of Rheumatology from February 2011 to August 2014y., all gave written informed consent to participate in the study. Therapy after delivery consisted of 400-1200mg/day Ibuprofen - 27 (84.4%) patients, and Metypred 4-12mg/day - 24 (75%) patients. Patients were subjected to thorough examination at 1, 3, 6 and 12 months after delivery. Data are presented as Me [IQR]. <h3>Results</h3> 27 out of 32 (84.4%) patients did not discontinue breastfeeding. The duration of lactation was from 2 weeks to 12 months (Me =2.5 [1.6] months). The lactation was suppressed immediately after birth in 5 cases: in 2 - due to the high activity of RA, in 2 – on mother9s request, and in 1 – because of perinatal death of the child. Exacerbation of the disease within 3 [1.5-3.5] months after delivery was the main reason for not breastfeeding in 14 (43.8%) cases. In 12 (37.5%) patients breastfeeding was disrupted due to low or disappearing milk supply within 2 [1.7] months after the birth. Only 4 (12.5%) patients were breastfeeding for 12 or more (up to 16) months. All these patients had low RA activity (n=3) or RA remission (n=1). <h3>Conclusions</h3> RA exacerbation requiring active drug therapy in mothers was the key reason for not breastfeeding in 16 (50%) cases. <h3>Disclosure of Interest</h3> None declared
Diabetes Mellitus and Exercise
Authors: Kousei Yoh
Journal: Diabetes Care (1992)

Diabetes mellitus is one of the most important life-style related diseases. As for the type 2 diabetes mellitus in particular, lack of exercise has a large influence on the onset and disease progress. We can improve glucose tolerance by exercising. Exercise is the most important fundamental treatment in diabetes mellitus. Continuation and safety become important to let exercise therapy succeed. It is important with a diabetic that a lot of patients without exercise habit should start to gain exercise habit. When we expect an exercise effect, we should take consideration of intensity and volume in exercise for performing. We should consider each contraindication matter even if we put it to have many complications with a diabetic when we perform exercise therapy. A case-by-case exercise treatment in diabetic patient is required.
The Effect of Gradations in Mineral Content, Matrix Alignment, and Applied Strain on Human Mesenchymal Stem Cell Morphology within Collagen Biomaterials
Authors: Laura C. Mozdzen, Stephen D. Thorpe, Hazel R. C. Screen, Brendan A. C. Harley
Journal: Advanced Healthcare Materials (2016)

The tendon‐bone junction is a unique, mechanically dynamic, structurally graded anatomical zone, which transmits tensile loads between tendon and bone. Current surgical repair techniques rely on mechanical fixation and can result in high re‐failure rates. A new class of collagen biomaterial that contains discrete mineralized and structurally aligned regions linked by a continuous interface to mimic the graded osteotendinous insertion has been recently described. Here the combined influence of graded biomaterial environment and increasing levels of applied strain (0%–20%) on mesenchymal stem cell (MSC) orientation and alignment have been reported. In osteotendinous scaffolds, which contain opposing gradients of mineral content and structural alignment characteristic of the native osteotendinous interface, MSC nuclear, and actin alignment is initially dictated by the local pore architecture, while applied tensile strain enhances cell alignment in the direction of strain. Comparatively, in layered scaffolds that do not contain any structural alignment cues, MSCs are randomly oriented in the unstrained condition, then become oriented in a direction perpendicular to applied strain. These findings provide an initial understanding of how scaffold architecture can provide significant, potentially competitive, feedback influencing MSC orientation under applied strain, and form the basis for future tissue engineering efforts to regenerate the osteotendinous enthesis.
Notes from the Field: Intoxication and Deaths Associated with Ingestion of a Racing Fuel and Carbonated Soft Drink Mixture — Tennessee, January 2016
Authors: Mary-Margaret A. Fill, Donna L. Seger, John R. Dunn, William Schaffner, Timothy F. Jones
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In January 2016, the Tennessee Poison Center and Tennessee Department of Health learned of the deaths of two adolescents, and the nonfatal intoxication of two other adolescents, after ingestion of a mixture of racing fuel (approximately 100% methanol) and a carbonated soft drink. The Tennessee Department of Health reviewed medical records and police reports to learn more about the racing fuel source, assess ongoing risk, and guide prevention efforts. These are the first reported deaths in the United States associated with ingestion of this racing fuel mixture.
OC-018 Obesity and type 2 diabetes are predominant risk factors underlying previously undetected cirrhosis in the general population
Authors: DJ Harman, EA Wilkes, MW James, SD Ryder, TR Card, GP Aithal, IN Guha
Journal: Gut (2015)

<h3>Introduction</h3> Epidemiological studies have attributed the rising cirrhosis incidence and mortality in the UK predominantly to excess alcohol consumption. However, obesity acts synergistically with alcohol to increase the risk of cirrhosis. In addition, asymptomatic liver disease goes undetected; as a result nearly 50% of cirrhotics are diagnosed when presenting with hepatic decompensation. We utilised Transient Elastography (TE) to screen at-risk individuals in the general population, aiming to establish the prevalence of undetected liver cirrhosis and the risk factors underlying these cases. <h3>Method</h3> The study was undertaken in 4 general practices in Nottingham between February 2012 and September 2014. The total adult patient population was 20,868. Patients with pre-defined risk factors for chronic liver disease (hazardous alcohol use as identified by general practitioner (GP), type 2 diabetes and/or persistent ALT rise with negative serology) were identified from the GP electronic records and invited for TE even if liver enzymes were normal. TE was performed by trained nurses at the general practice sites. Liver stiffness of ≥8 kilopascals prompted review by a Consultant Hepatologist and liver cirrhosis was confirmed by established histological, radiological and biochemical methods. <h3>Results</h3> Of 2,022 patients eligible, 919 attended TE; 899 (97.8%) had valid liver stiffness measurements. Elevated liver stiffness was detected in 230 patients (25.6%) and cirrhosis in 26 (2.9%). Liver enzymes were normal in 16/26 (61.5%) of cirrhosis cases. Prior to the study, 23 patients with cirrhosis (aetiologies: alcohol (14), viral hepatitis (5), Non-alcoholic steatohepatitis (1), other (3)) had been identified; a diagnosed cirrhosis prevalence which was not significantly different compared to general population estimates of 76.3 cases per 100,000. Following the study, the prevalence of cirrhosis diagnosis was 49/20,868 (234.8 cases per 100,000 (95% CI 201.3–268.3)) was 3 fold higher than the previous general population estimate. Risk factors for new cirrhosis diagnoses were obesity and/or type 2 diabetes in 16 patients (61.5%), alcohol alone in 3 (11.5%) and both alcohol and obesity and/or diabetes in 7 (26.9%). <h3>Conclusion</h3> Investigating defined risk factors for liver disease using TE in a community setting detects a significant amount of previously unidentified cirrhosis. Cirrhosis prevalence in the general population is at least 3 times recent UK estimates. Obesity and type 2 diabetes are the predominant risk factors underlying previously undetected cirrhosis cases. <h3>Disclosure of interest</h3> None Declared.
Adjuvant chemotherapy for elderly patients (age 70 or older) with gastric cancer after gastrectomy with D2 dissection: A single-center experience.
Authors: Jae-Cheol Jo, Jin Ho Baek, Su-Jin Koh, Gyu Yeol Kim, Hong Rae Cho, Hawk Kim, Jae Hoo Park, Young Joo Min
Journal: Journal of Clinical Oncology (2014)

117 Background: Adjuvant chemotherapy for gastric cancer after gastrectomy with D2 dissection can be recommended. However, there are limited data of survival benefit in the elderly. We sought to investigate the use of adjuvant chemotherapy for patient ≥70 years old with stage II or III gastric cancer and identify its impact on survival. Methods: Patient ≥70 diagnosed with stage II or III gastric cancer at the Ulsan University Hospital from 2008-2012 were identified. A retrospective analysis of electronic and paper patient records was performed to identify baseline characteristics, chemotherapy used, toxicity, and survival. Results: A total of 277 patients ≥70 years old underwent gastrectomy with D2 dissection from 2008-2012. Of these, 94 patients were pathologically diagnosed as stage II or III gastric cancer. Among the 94 patients, 58.5% of patients (n=55) received adjuvant chemotherapy and 39 patients received regular check-up without chemotherapy. Fluoropyrimidine alone regimens including TS-1 (n=26) and Didox (n=22) were more commonly used compared with fluroropyrimidine-platinum combination regimens (n=7). With median follow-up of 30.9 (range, 0.8-65.5 months), the median relapse-free survival (RFS) of patients with adjuvant chemotherapy or regular follow-up only was 39.1 and 26.1 months (P = 0.027). Multivariate analysis revealed that the adjuvant chemotherapy was associated with longer RFS (hazard ratio 0.51; 95% confidence interval 0.27 – 0.98). There was a trend toward improved overall survival (OS) in the adjuvant chemotherapy group, with a median OS of 51.2 months compared with that of 44.5 months in the regular follow-up only group (P= 0.242). Toxicities in adjuvant chemotherapy were generally tolerated. Conclusions: In elderly patients (aged 70 or older) with stage II or III gastric cancer after gastrectomy with D2 dissection, adjuvant chemotherapy may carry a potential survival benefit for those who receive it. Further well-designed prospective studies are needed to confirm these finding.
Prevention of Rh-haemolytic disease.
Authors: J C Woodrow
Journal: BMJ (1966)

PointersPrevention of Rh-haemolytic Disease: Results of a combined clinical trial from Liverpool, Sheffield, Leeds and Bradford, and Baltimore, U.S.A., show that Rh immunization of Rh- negative mothers by their Rh-positive babies can be prevented (p.907).Leader on this page.Adrenal Cortex: In the second part of his Lumleian lecture Dr. C. L. Cope discusses aldosterone and its relation
Applied field epidemiology programme in Spain
Authors: J. F. Martinez Navarro, D Herrera, Candi Sanchez Barco
Journal: Eurosurveillance (2001)

In 1994, the Instituto de Salud Carlos III (ISCIII; Carlos III Health Institute) of the Spanish Ministry of Health and the Consumer (MSC) created the Programa de Epidemiología Aplicada de Campo (PEAC; Applied Field Epidemiology Programme). The programme is managed by the Centro Nacional de Epidemiología (National Epidemiological Centre) in collaboration with the Escuela Nacional de Sanidad (National School of Health), and supported by General Direction for Health and Consumer of MSC and the Health Councils (Consejerías de Sanidad) of the autonomous regions. The PEAC runs a masters degree programme in applied field epidemiology, in which degrees are conferred by the National School of Health. As PEAC is a national programme, it forms a part of the European Program for Intervention Epidemiology Training (EPIET) and is a member of the Network Training for Epidemiology Public Health Intervention (TEPHINET), the association of 27 regional and national programmes of the acting Intervention Epidemiology Training Programs.
A fatality during haloperidol treatment: mechanism of sudden death
Authors: J Modestin, R Krapf, W Böker
Journal: American Journal of Psychiatry (1981)

The authors report a case of unexpected sudden death in a woman receiving relatively high dose of haloperidol. They postulate that drug-induced laryngeal spasm leading to cardiac arrest via vagal reflexes may represent the mechanism of neuroleptic sudden death in some cases.
Syphilis on the Rise
Authors: Meredith E. Clement, Charles B. Hicks
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnosis of mental disorder in adults and increased use of health services in four outpatient settings
Authors: E W Hoeper, G R Nycz, D A Regier, I D Goldberg, A Jacobson, J Hankin
Journal: American Journal of Psychiatry (1980)

The differential use of medical services by patients with and those without a diagnosis of mental disorder was examined in four adult populations by age, sex, diagnosis, and medical department used. The four settings offered comprehensive services to patients who varied greatly in socioeconomic status. In all four settings patients with a diagnosis of mental disorder used all services and general health services more than patients without such a diagnosis. Results document increased medical morbidity and a greater likelihood of a diagnosis of an ill-defined condition in patients with mental disorder than that found in patients without a diagnosis of mental disorder.
Sleepless
Authors: Joshua B Alley
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OP0235 Neuroimaging in Differentiating Cerebral Amyloid Angiopathy with and Without Inflammation:
Authors: C. Salvarani, G. Hunder, R. Brown, T. Christianson, C. Giannini, J. Morris
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In a subset of patients with cerebral amyloid angiopathy (CAA) vascular inflammation is also present. Two pathologic subtypes have been described: one with perivascular inflammation (CAA-related inflammation or CAA-RI), and the second with a vasculitic transmural inflammatory infiltrate (Aβ-related angiitis or ABRA). <h3>Objectives</h3> To investigated the role of imaging in differentiating CAA with and without inflammation. <h3>Methods</h3> 54 patients had pathological evidence of CAA with or without inflammation at the Mayo Clinic (Rochester, MN) over 25 years. All available pathologic specimens were re-reviewed by one neuropathologist (CG). Neuroimaging findings (brain CT and/or MRI) at the time of diagnosis were available in all patients. All neuroradiologic findings were reviewed by a neuroradiologist (JM) who was blinded to the histologic diagnosis. Clinical data were also collected. <h3>Results</h3> The Table shows the radiologic findings at presentation of the 27 patients with CAA without inflammation, 22 with ABRA and 5 with CAA-RI. Strictly leptomeningeal disease and leptomeningeal process with infiltrative white matter were significantly more frequent radiological presentations in patients with ABRA and CAA-RI compared to those with CAA (10/27, 37% versus 1/27, 3.7%, p=0.005; and 11/27, 40.7% versus 1/27, 3.7%, p=0.002, respectively), while lobar hemorrhage was more frequent in patients with CAA (18/27, 66.7% versus 2/27, 7.4%, p&lt;0.0001). Globally, leptomeningeal involvement at presentation was present in 77.8% (21/27) of patients with ABRA + CAA-RI and in only in 7.4% (2/27) of patients with CAA (p&lt;0.0001). <h3>Conclusions</h3> Leptomeningeal enhancement at MRI may enable differentiation between CAA with and without inflammation. Leptomeningeal enhancement associated with lobar infiltrative white matter T2 hyperintensity9s also helps differentiate these entities from the more common infiltrating low-grade gliomas. <h3>Disclosure of Interest</h3> None declared
FRI0122 Biologic DMARDs in Patients with Rheumatoid Arthritis on a Spanish Registry: Predictors of Therapy Discontinuation Due to Remission:
Authors: M.V. Hernández, J.A. Gόmez-Puerta, J.D. Cañete, J.J. Gόmez-Reino, R. Sanmartí
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Remission is achievable in many patients receiving biologic therapies. Only limited information on predictors of discontinuation of biologic therapy in patients with rheumatoid arthritis (RA) is available. <h3>Objectives</h3> To evaluate how often biologic DMARDs are discontinued due to remission and to identify predictors of discontinuation of biologic treatment in patients from a Spanish registry. <h3>Methods</h3> Retrospective, observational cohort study based on data from a national registry. RA patients receiving a first biologic DMARD for ≥3 consecutive months between April 1998 and December 2013 were included. Patients receiving rituximab were excluded. The study endpoint was defined as discontinuation of biologic DMARD due to remission, defined by treating physician. Censoring occurred administratively (end of registry data), when patients ceased treatment due to other causes (side effect, lack of efficacy, pregnancy, etc.) or due to loss to follow up. Multivariate proportional sub-distribution hazards (SHR) models were used to evaluate associations between predictor factors of discontinuation due to remission, discontinuation due to lack of efficacy, side effects, loss to follow-up or other causes as competing events. <h3>Results</h3> 3,516 patients were included, of which 3,161 patients had received ≥3 months of biologic DMARD: 753 patients discontinued treatment due to side effects, 867 patients due to lack of efficacy, 101 were lost to follow-up, 143 for other reasons, 48 due to pregnancy, and 15 patients due to unknown reasons. 1175 patients were receiving biological DMARD at the study conclusion. Only 59 (1.8%) patients discontinued biologic therapy due to remission. The Table shows baseline characteristics of patients at initiation of biologic DMARDs by discontinuation for remission. After multivariate SHR analysis, sex (female) (SHR 2.81, 95% CI 1.01-7.83), age at onset (SHR 1.04, 95% CI 1.01-1.07) and disease duration (HR 0.94, 95% CI 0.90-0.98) were significant predictors of discontinuation due to remission adjusting by methotrexate and steroids use. <h3>Conclusions</h3> Less than 2% of RA patients discontinued biologic DMARD therapy due to disease remission. Sex, age at onset and disease duration were predictors of this discontinuation. The prognosis of biologic-free patients after remission is still unknown and further studies are required to determine their clinical outcomes. <h3>Disclosure of Interest</h3> None declared
Against “Healthy Paternalism” at the End of Life
Authors: Jonathan M. Marron, Robert D. Truog
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal