tbuckley/cabot-search huggingface dataset:
SAT0010 Role of Synovial Fluid Proteins in Triggering Crystal-Induced Inflammation with ATP Involvement
Authors: A. Scanu, F. Oliviero, L. Gruaz, R. Luisetto, P. Frallonardo, R. Ramonda, D. Burger, L. Punzi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Monosodium urate (MSU) crystal deposition in joints promotes leukocyte infiltration and release of inflammatory mediators, in particular IL-1β. However, the induction of IL-1β production by MSU crystals requires a costimulus. Recently, we have demonstrated that serum and plasma are able to induce differently crystal-induced inflammation, hypothesizing that plasma proteins could play a role in triggering this inflammatory reaction. Afterwards, we have observed that factors with molecular weight (MW) &gt;50 kDa contained in synovial fluid (SF) synergize with MSU crystals to induce an inflammatory response in mononuclear cells. <h3>Objectives</h3> The aims of this study were to investigate whether three of the high abundant proteins in SF with MW&gt;50 KDa, i.e. Albumin (HSA) (MW: 66.5 KDa), Haptoglobin (Hp) (MW: 100 kDa) and Fibrinogen (F) (MW: 340 kDa), may provide help to MSU crystals in induction of inflammation, and to determine whether ATP is one of the involved etiologic agents. <h3>Methods</h3> MSU crystals were prepared by Denko9s method and sterilized by heating at 180°C for 2 h before each experiment. The human leukemic monocytic cell line THP-1 was stimulated for 24 h with MSU crystals (0.5 mg/ml) in the presence or absence of one of the three proteins. In some experiments apyrase (1 U/ml) was added to degrade extracellular ATP. Culture supernatants were tested by ELISA for IL-1β and IL-8 production. IL-1β mRNA was isolated from cells and analyzed by quantitative RT-PCR (qPCR). <h3>Results</h3> Exposure of THP-1 cells to MSU crystals or F (1 mg/ml) induced a moderate release of IL-8 (MSU: 211.66±32.00 pg/ml; F: 466.08±49.16 pg/ml), but not of IL-1β. Cotreatment of cells with MSU crystals and HSA or Hp (0.1 mg/ml) did not affect the cytokine production, while F led to a significantly enhanced IL-1β (71.15±5.64 pg/ml) and IL-8 (2649.62±55.91 pg/ml) secretion. HSA and Hp alone did not cause changes on the cytokine levels. qRT-PCR analysis indicated consistently increased IL-1β mRNA expression in THP-1 cells treated with fibrinogen compared with non-treated cells (49.75±3.54 fold); this was markedly amplified by MSU crystals (103.25±5.73 fold). IL-1β mRNA levels was not enhanced by crystals alone. Apyrase significantly reduced the secretion of IL-1β (20%) and IL-8 (47%) induced by costimulation with MSU and F. <h3>Conclusions</h3> This study shows that in the presence of MSU crystals, F but not HSA and Hp, induces an inflammatory response in mononuclear cells. F could account for the synergizing effect of SF with MSU in the gouty joint. This component increases the production and expression of pro-inflammatory cytokines, in particular of IL-1β and IL-8, and its effect may be in part mediated by extracellular ATP. This work is supported by FIRA foundation and IBSA foundation <h3>Disclosure of Interest</h3> None declared
SP0156 Work Disability Management in Musculoskeletal Disorders
Authors: A. Bieleman
Journal: Annals of the Rheumatic Diseases (2015)

Participation in (paid) work is an important aspect of life. Work generates an income, leads to social contacts, may stimulate personal development, self esteem and identity. Work is generally good for health and well-being, provided the working conditions are alright. Musculoskeletal disorders (MSD) are a major cause of work disability. It is important for health professionals to realize that patients may not only suffer from pain and impairment but may also become work disabled, which has large consequenses. They should address work-related problems in their contacts with persons with MSD, to analyze the relation between work load and health condition. The work load may cause (or contribute to) symptoms and the course of the disorder. Conversely, the disorder may affect the work capacity, leading to reduced productivity (presenteeism) or sick leave (absenteeism). Modified work tasks, ergonomic improvements or use of supportive devices may decrease the job load; adequate clinical management of the disorder and graded activity interventions may improve the work capacity of the person. There is a lot of evidence on the management of work disability in low back pain; work disability in rheumatoid arthritis and osteoarthritis is increasingly getting attention in research and clinical practice. This session will present state of the art knowledge on this issue; participants will be invited to discuss possibilities and barriers for clinicians and researchers in preventing work disability in musculoskeletal disorders. <h3>Disclosure of Interest</h3> None declared
Clinicopathologic Features of NSCLC Diagnosed During Pregnancy or the Peripartum Period in the Era of Molecular Genotyping
Authors: Ibiayi Dagogo-Jack, Justin F. Gainor, Rebecca L. Porter, Katherine R. Schultz, Benjamin J. Solomon, Sara Stevens, Christopher G. Azzoli, Lecia V. Sequist, Inga T. Lennes, Alice T. Shaw
Journal: Journal of Thoracic Oncology (2016)
Soundings: Cotswold churches
Authors: Kevin Barraclough
Journal: BMJ (2004)

There is something rather arresting about the inside of a medieval church in mid-winter. The air is cold and still, and the silence has a different quality within the deep stone walls. The grey half-light falls on flagstones worn smooth by the thousand year cohort who have been there before you. It is impossible not to feel transient.

In the winter I tour around these Cotswold churches on my mountain bike feeding my pineal gland on the morsels of sunlight. My family, who occasionally accompany me in the summer, fall away at the merest hint of frost. Medical friends who will put up with a eulogy about a Norman crypt are rare and need to be booked in advance. Consequently I often go touring on my own. It is a pilgrimage through the centuries that gets me out of the house and out of an age.

The unexpected thing is the riches that you tumble across in these open, deserted little churches. In Daglingworth there are simple white Saxon carvings set in the walls. The rather stark figures were cut out of the stone at a time when the villagers were still fighting off Vikings. A few years ago I met an elderly German couple in the church. They explained that the crucifixion carving was done in a style found only in Syria in the ninth and tenth centuries. What was a sculptor from Syria doing in the tiny village of Daglingworth a thousand years ago?

A few muddy miles up the valley the tiny Saxon church of Duntisbourne Rouse sits on a steeply sloping site above a flooded stream. In the churchyard the table tomb of John Jeffries, died 12 September 1611, bears a lament from his wife. Of their union: “One half lives. Alas why lives it longer. It lives to make my grief and sorrow stronger.”

The trouble about churches is that, like medicine, they are mostly about births, marriages, and deaths, and it is only the latter that leave the monuments. But even death is not unremittingly maudlin. In Kempsford church there is an epitaph for an Irish Regency peer called Coleraine. He had clearly led a colourful life, and he wished to be buried inside the church because he was afraid that the devil would get him if he was buried in the earth. His indulgent epitaph suggests he paid quite a lot for the privilege. “He was,” it states, “as good a Christian as his frail nature would allow.”
The comparison between FDG-PET and RECIST in detection and duration of response to RAD001 in patients with metastatic renal cell cancer (mRCC).
Authors: R. Mody, G. K. Doshi, R. J. Amato
Journal: Journal of Clinical Oncology (2010)

e15077 Background: A phase II study assessing the activity of RAD001 (Afinitor) in patients with metastatic clear cell renal cell carcinoma has been published in Cancer, 2009 115(11). The purpose is to compare the imaging modality, establish the initial response to FDG-PET in relation to conventional imaging and the duration of response with each modality. This will assist in establishing response criteria utilizing both metabolic activity in association with tumor measurements. Methods: 32 of 41 patients had FDG-PET and CT scan evaluation at baseline and restaging every 8 to 12 weeks. We compared the measurable metastatic lesions on CT measured by RECIST with the same metastatic site on FDG-PET using SUV units. Measured was the time to best response and time to progressive disease with each imaging modality. For FDG-PET progressive disease was defined as >10% in SUV uptake. A percent calculation change from baseline FDG-PET to response was determined. Results: Ten patients had progressive disease with both modalities. Eight with progressive disease (PD) on the FDG- PET scan prior to PD recorded on the CT scan. The other two patients had a similar time frame. Twenty-two patients were evaluable for comparison of percent change in RECIST at first metabolic response verse percent change in first FDG-PET response. 21 patients had a greater percent decrease in SUV units then on CT tumor measurement. The average change for metabolic response was 38.3% while for RECIST at the initial metabolic response it was 9.5%. Of the 22 patients we compared time to best response for RECIST and FDG-PET, 8 patients had an earlier response for FDG-PET, 11 had and earlier best response for RECIST and 4 had a similar interval. Conclusions: FDG-PET showed signs of earlier progression prior to the development of size progression. FDG-PET indicated a greater reduction in metabolic activity relative to size regression. FDG-PET or conventional imaging did not show a difference in time interval to best response obtained. The response in metabolic activity needs to be incorporated into the criteria when utilizing the molecular targeted agents such as an mammalian target of rapamycin (mTOR) inhibitor. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis
On Knowledge
Authors: Louis Kuritzky
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Membrane-Bound Fas (Apo-1/CD95) Ligand on Leukemic Cells: A Mechanism of Tumor Immune Escape in Leukemia Patients
Authors: Agnès Buzyn, Frederic Petit, Marina Ostankovitch, Suzanne Figueiredo, Bruno Varet, Jean-Gérard Guillet, Jean-Claude Ameisen, Jérôme Estaquier
Journal: Blood (1999)
Gas gangrene of the eye.
Authors: A JUETTE, H OEHRING
Journal: BMJ (1971)

now being developed for use under clinical conditions, and this, coupled to electro-diagnosis, should prove helpful for the provision of screening facilities.At the same time it is important to clarify the clinical picture, to learn more about the several causes of the condition, and to determine whether there is, for example, an age factor, as this would help to get the problem into some sort of perspective.
PTU-199 A regional assessment of perineal wound complications after abdomino-perineal excision of the rectum
Authors: N Sengupta, J Tankel, I Panagiotopoulou, D Pournaras, S Pilgrim, C Challand, N Keeling, K Aryal, R Lal, K Brown, M Obichere, S Gurjar, F Younis
Journal: Gut (2015)

<h3>Introduction</h3> Perineal wound complications following abdomino-perineal excision of the rectum (APER) are an important cause of morbidity in the treatment of low rectal cancers. Complications result in prolonged hospital stay, hospital readmission and higher medical expenditure. Our primary aim was to describe the short and long-term outcomes of the perineal wound and factors affecting wound healing after APER. <h3>Method</h3> We performed a retrospective case note review of consecutive patients who underwent APER between January 2002 and January 2012 in three centres in the East of England. Demographic data and factors affecting perineal wound healing were analysed. <h3>Results</h3> 242 patients (155 male, 76 female; median age 70 years) underwent APER. The median time to perineal wound healing was 2 months (range 1–37 months) with a minor perineal complication rate of 23.6% and major perineal complication rate of 22.7%. Perineal wound healing was significantly adversely impacted by use of the lithotomy operative position (p = 0.000), a positive circumferential resection (CRM) margin (p = 0.006), adverse tumour grade (p = 0.003) and lymph node (LN) positivity (p = 0.002). Patient factors (immunosuppression, diabetes mellitus and smoking) or preoperative treatment modalities (neoadjuvant chemoradiotherapy) were not statistically significant. <h3>Conclusion</h3> Poor perineal wound healing after APER was associated with lithotomy patient positioning, CRM positivity and tumour grade. <h3>Disclosure of interest</h3> None Declared.
Genetic profiling of hepatocellular carcinoma using next-generation sequencing
Authors: Kornelius Schulze, Jean-Charles Nault, Augusto Villanueva
Journal: Journal of Hepatology (2016)

Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, both clinically and from a molecular standpoint. The advent of next-generation sequencing technologies has provided new opportunities to extensively analyze molecular defects in HCC samples. This has uncovered major cancer driver genes and associated oncogenic pathways operating in HCC. More sophisticated analyses of sequencing data have linked specific nucleotide patterns to external toxic agents and defined so-called ‘mutational signatures’ in HCC. Molecular signatures, taking into account intra- and inter-tumor heterogeneity, and their functional validation could provide useful data to predict treatment response to molecular therapies. In this review we will focus on the current knowledge of deep sequencing in HCC and its foreseeable clinical impact.
Cortical Volume Loss and Neurologic Dysfunction in Multiple Sclerosis
Authors: Michael K. Racke, Jaime Imitola
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
THU0271 Pseudotumoral Behçet's Disease: A Review of the Past 30 Years
Authors: A. Riveros Frutos, L. Martínez-Estupiña, S. Alonso, M. Martínez-Morillo, A. Olivé, F.J. Lόpez-Longo, I. Monteagudo, L. Carreño Pérez
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Behçet9s disease is a recurrent systemic vasculitis which may have neurological manifestations: Neuro-Behçet (NB). The estimated frequency is 1-59%. It is more common in males. Central neurological system (CNS) involvement, presenting as pseudotumoral masses are very rare <h3>Objectives</h3> To describe the clinical characteristics, incidence, treatment, and outcome of patients diagnosed of pseudotumoral neuro-Behçet disease. We performed a systematic review of cases reported in the literature. <h3>Methods</h3> Desing: retrospective (1984-2014). Location: Two University hospitals. A hundred and fifty five patients records were reviewed with a diagnosis of Behçet9s disease from the Rheumatology service data base. Inclusion criteria: patients with pseudotumoral neuro-Behçet. A systematic search of all published cases with this diagnosis through PubMed was also performed. (1987-2014, keywords: pseudotumoral, neuro-Behçet) <h3>Results</h3> Three new cases of pseudotumoral Neuro-Behçet were identified. After a systematic review, other 27 cases were found with this diagnosis. The whole series were composed of 30 patients: a predominance of male (73.3%) was observed, with a mean age: 39.2±12.1 (range: 23-63 years). The mean duration of Behçet9s disease prior to the diagnosis of NB, was 9.3±7.8 years, in 50% of patients. The diagnosis was performed simultaneously or later in the remaining patients. The location of the lesion was: capsular thalamus region 15 (50%), peduncle and cerebellar 4 (13.3%), fronto parietal region 2 (6.7%), fronto temporal and temporo -occipital region in 1 (3.3%). Four (13.3%) patients presented more than one lesion. In 14 (46.7%) patients biopsy of the brain mass was performed in order to confirm the diagnostic. All reported patients were initially treated with high-dose of glucocorticosteroids (oral or intravenous), other immunosuppressive agents such as azathioprine, cyclophosphamide, methotrexate or chlorambucil were added. Three (10%) patients (2 of own serie and 1 described in literature) were treated with biological agents (anti TNF alpha, rituximab and tocilizumab). Only in one case plasmapheresis was performed because of refractory disease. Most patients showed progressive improvement, and three (10%) patients died. <h3>Conclusions</h3> The presence of pseudotumoral lesions is a very rare presentation of Neuro-Behçet. It is more common in males and occurs years after diagnosis; however it can also occurs simultaneously. A differential diagnosis with other CNS diseases and malignancy is mandatory. The response to glucocorticoides plus immunosuppressive drugs is good. Biological agents may be useful for refractory cases. <h3>Disclosure of Interest</h3> None declared
GMC asks for child pornography case to be referred to High Court
Authors: Clare Dyer
Journal: BMJ (2015)

The UK General Medical Council has asked the Professional Standards Authority for Health and Social Care to consider referring the case of a doctor who viewed child pornography on his computer to the High Court, after the Medical Practitioners Tribunal Service decided to let him stay on the medical register.

The GMC’s chief executive, Niall Dickson, told the Derby Telegraph that he was “appalled” by the tribunal service’s decision not to erase the consultant cardiologist Steven Burn from the register, after the GMC called for him to be struck off.

His reaction came in a letter to the paper …
Atrial Septal Defect
Authors: YU-CHEN LEE, LEONARD SCHERLIS
Journal: Circulation (1962)

The results of the electrocardiographic, vectorcardiographic, and hemodynamic studies of 70 patients with atrial septal defects are analyzed. Serial electrocardiograms and vectorcardiograms were obtained in 16 patients following surgery. The incidence of the rSR' and rSr' patterns in the right precordial leads was 60 per cent. To a limited extent, the configuration of the electrocardiogram is related to right ventricular pressure and PBF/SBF. However, no quantitative assessment could be made by determining the magnitude of R or R' in lead V 1 . The vectorcardiogram is an important adjunct to the electrocardiogram in detecting right ventricular hypertrophy. As the right ventricular pressure increases, the QRS sÊ loop tends to shift more to the right and anteriorly. Although it can be generally stated that the rSR' configuration in atrial septal defects is usually due to right ventricular hypertrophy, this configuration is also due to terminal conduction delay or terminal conduction delay associated with right ventricular hypertrophy in a significant number of instances. The vectorcardiogram is useful in detecting terminal conduction delay in patients with rSR' in the right precordial leads. It was also of value in determining the presence of right ventricular hypertrophy in combination with terminal conduction delay. The evidence of terminal conduction delay may disappear after successful repair of atrial septal defects. Left axis deviation, superior displacement, and counterclockwise direction of inscription of the QRS sÊ loop in the frontal plane are valuable signs for differentiating ostium primum defects from ostium secundum defects. Each of the eight proved instances of ostium primum defects had these typical features.
Recent advances: Neurosurgery
Authors: F M ANDERSON
Journal: BMJ (1999)

from analytical epidemiological studies of testicular cancer, which have shown consistent associations with low birth weight 14 22 and with congenital malformations of the male sexual organs. 13 23 In patients with testicular cancer who are treated by surgery alone low sperm counts and high values of follicle stimulating hormone were observed at the time of orchidectomy and during the following years. 24 25In addition, studies of testicular tissue from such patients have shown that abnormal morphology and impaired spermatogenesis are common features, both in the testicle with cancer 26 and in the contralateral testicle. 24 This probably reflects a condition of permanently impaired reproductive capacity that precedes and is not caused by the presence of a tumour in the other testicle. ConclusionWe found that testicular cancer occurs more commonly in men who have fathered no or only few children when the age of the man is taken into account.In conjunction with studies of testicular histology and function these data support the hypothesis that male subfertility is associated with a high risk of testicular cancer.The most plausible explanation for this association is the existence of causal factors that are common to both subfertility and testicular cancer.The epidemiology and biology of testicular cancer suggest that such common causes may act prenatally.Lars Grønbjerg assisted with the data analysis.
Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013
Authors: Valery L Feigin, Gregory A Roth, Mohsen Naghavi, Priya Parmar, Rita Krishnamurthi, Sumeet Chugh, George A Mensah, Bo Norrving, Ivy Shiue, Marie Ng, Kara Estep, Kelly Cercy, Christopher J L Murray, Mohammad H Forouzanfar
Journal: The Lancet Neurology (2016)
Expression Pattern Of Mirnas Is Not Predictive For Poor Prognosis In BCR-ABL1-Like Childhood Acute Lymphoblastic Leukemia
Authors: Farhad Akbari Moqadam, Ellen Lange-Turenhout, Arian van der Veer, João R.M. Marchante, Rob Pieters, Monique L. Den Boer
Journal: Blood (2013)