tbuckley/cabot-search huggingface dataset:
PTH-349 Use of methylene blue to identify ureters under fluorescence during laparoscopic and open colorectal surgery
Authors: T Yeung, D Volpi, G Nicholson, N Buchs, C Cunningham, R Guy, R Hompes, I Lindsey, B George, O Jones, B Vojnovic, F Hamdy, N Mortensen
Journal: Gut (2015)

<h3>Introduction</h3> Iatrogenic ureteric injury is a serious complication of colorectal surgery. Fluorescence image guided surgery (FIGS) is an expanding field and can potentially make operations safer for patients and prevent inadvertent ureteric injury. Intravenously administered methylene blue is excreted renally and concentrated in the urine. It is fluorescent at 660nm and can therefore be used to locate ureters intraoperatively using fluorescence enabled cameras and laparoscopes. The aim of this study is to assess the use of methylene blue under fluorescence to identify ureters during laparoscopic and open colorectal surgery. The primary objective is to compare ureter identification using white light versus fluorescence in each patient. The secondary objectives are to quantify the level of fluorescence at different time points following administration of methylene blue and to work out the optimum time to visualise the ureters. <h3>Method</h3> All adult patients undergoing either laparoscopic or open colorectal surgery were considered for inclusion into this study. Exclusion criteria were pregnancy, significant renal or hepatic impairment, and patients taking SSRIs with a risk of developing serotonin syndrome. Between 0.25 – 1 mg/kg of methylene blue was administered intravenously during the operation. Background and peak fluorescence were measured at multiple time points during the procedure, using custom-made fluorescence-enabled laparoscopes and open cameras that could detect fluorescence at 660 nm. <h3>Results</h3> 8 consecutive patients undergoing colorectal surgery were recruited into this study, of which 6 were laparoscopic and 2 were open procedures. Out of 11 ureters, 10 were successfully visualised under fluorescence (example shown in image below). The mean time to peak fluorescence was 14.5 min after intravenous methylene blue injection. There was a low background signal, and the mean signal to background ratio was 2.74. Fluorescence could be detected up to 75 min after injection. This technique was considered useful in 4 patients: in one case, the ureter was more medial than initially thought, in another case, the ureter was not seen on white light but was seen under fluorescence, and in two cases, the ureters were traced from the pelvic brim all the way to the kidneys. There were no complications after administration of methylene blue. <h3>Conclusion</h3> The use of methylene blue is a safe and simple technique to identify the location of ureters under fluorescence. Larger clinical studies are required to identify which subsets of patients would benefit from this form of fluorescence image guided surgery. <h3>Disclosure of interest</h3> None Declared.
Loss Of BTG1 Function Promotes ETV6-RUNX1-Mediated Leukemic Transformation
Authors: Esther J.H. Tijchon, Liesbeth van Emst, Dorette van Ingen Schenau, Laurens T. van der Meer, Owen Williams, Peter M. Hoogerbrugge, Blanca Scheijen, Frank N. van Leeuwen
Journal: Blood (2013)
AB0764 Gender Differences in Axial Spondyloarthritis
Authors: G. Kenar, G. Can, P. Cetin, H. Yarkan, I. Sari, M. Birlik, N. Akkoc, F. Onen
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Gender differences in demographic and clinical features of ankylosing spondylitis (AS) has consistently been demonstrated in several cohorts but there is little knowledge of those of axial spondyloarthritis (axSpA) as a whole group and of nonradiographic axial spondyloarthritis (nr-axSpA). <h3>Objectives</h3> The aim of this study was to assess the gender differences in axSpA. <h3>Methods</h3> Demographic and clinical data in our local axSpA database were evaluated and compared between male and female patients. Subgroup analyses in patients with AS/radiographic axSpA (r-axSpA) and nr-axSpA were also performed. <h3>Results</h3> There were 438 patients with axSpA [279 male (64%)], who fulfilled the ASAS classification criteria (Table 1). 349 out of them were classified as having AS/r-axSpA [236 male (68%)] and 89 as having nr-axSpA [43 male (48%)]. In female patients with axSpA, age of disease onset and age of diagnosis was older and delay of the diagnosis was longer compared with male patients (p&lt;0.05). Peripheral arthritis and dactilitis were seen more in females (p&lt;0.05) but entesitis was more frequent in males. At the time of diagnosis, BASDAI was higher in females (p&lt;0.05); but BASMI scores (p&lt;0.05) and CRP (p&lt;0.05) were higher in males. Although neck pain was more common in female axSpA patients; cervical rotation disability and BASMI score assessments were worse in males (Table 1). When subgroup analysis was performed, females with nr-axSpA were found as having worse BASDAI (p&lt;0.05) and BASFI scores (p&lt;0.05) and males with AS as having higher CRP levels (p&lt;0.05) and worse BASMI scores (p&lt;0.05). <h3>Conclusions</h3> This study demonstrated that AS/r-axSpA was more prevalent among men but the prevalence of males and females in patients with nr-axSpA was similar. While subjective disease activity parameters were higher among women with axSpA as well as in those with nr-axSpA, men with axSpA experienced higher objective disease activity parameters and more restricted spinal mobility as well as in those with AS/r-axSpA. However, objective disease activity and spinal mobility scores were similar between women and men with nr-axSpA. <h3>Disclosure of Interest</h3> None declared
THU0486 The Predictor for Disease Specific-Quality of Life in Patients with HIP and Knee Osteoarthritis: Mental Health
Authors: F.F. Ayhan, S. Gümrük, E. Ceceli, P. Borman, A. Karagöz
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Enhancing quality of life (QoL) in older adults with physical limitations is a significant challenge for healthcare providers. One of the first steps to improving quality of life in older adults with osteoarthritis (OA) is developing a better understanding of the set of factors that coexist and influence QoL. <h3>Objectives</h3> To determine the predictors of disease-specific QoL in a sample of knee and hip OA in a tertiary care hospital and to evaluate physical activity, mental health, social functioning and social support components of OA-specific-QoL questionnaire in addition to score of pain, ESR, CRP, x-ray, and co-morbid conditions. <h3>Methods</h3> A cross-sectional, methodological exploration from an inpatient sample (N=100) of adults (mean age: 64.51±8.78, 83 female) with OA of the knee (N=78) and hip (N=22) according to the ACR- clinic and radiograhic knee OA or hip OA classification criteria was performed. Clinical, laboratory and radiographic datas were analysed using SPSS15.0. The osteoarthritis knee and hip quality of life questionnaire (OAKHQOL) consisting of 43 items in five dimensions and three independent items were fullfilled by patients (1). <h3>Results</h3> Means of pain-VAS scores at rest and movement were moderately high (5.14 and 6.64). Twenty patients were in stage I, 36 patients were stage II, 30 patients were in stage III and remaining 14 patients were in stage IV OA according to the Kellgren-Lawrence system. All of the patients were overweight or obese. Related comorbidities were common such as 48 hypertensive, and 33 diabetic.Lineer regression analyses showed that mental health (<i>R</i><sup>2</sup>=0.668, <i>p</i>=.000), pain (<i>R</i><sup>2</sup>=0.591, <i>p</i>=.000), and vehichle-transfer difficulties (<i>R</i><sup>2</sup>=0.572, <i>p</i>=.000) were the most important predictors for OA-specific-QOL. <h3>Conclusions</h3> The findings of this study provide a foundation or targeted interventions to improve QoL and the importance of mental health older adults with OA of the knee and hip. The individual problem solving including both mental and physical approaches may help these patients to improve OA-specific-QoL. Mental health and cognitive approaches should be incorporated to OA management. <h3>References</h3> Rat AC, Coste J, Pouchot J, Baumann M, Spitz E, Retel-Rude N, Le Quintrec JS, Dumont-Fischer D, Guillemin F. OAKHQOL: a new instrument to measure quality of life in knee and hip osteoarthritis. J Clin Epidemiol. 2005 Jan;58(1):47-55. <h3>Disclosure of Interest</h3> None declared
Cancer Screening Navigation
Authors: Richard Wender
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Direct measurement of T cell receptor affinity and sequence from naïve antiviral T cells
Authors: Shu-Qi Zhang, Patricia Parker, Ke-Yue Ma, Chenfeng He, Qian Shi, Zhonghao Cui, Chad M. Williams, Ben S. Wendel, Amanda I. Meriwether, Mary Alice Salazar, Ning Jiang
Journal: Science Translational Medicine (2016)

Direct assessment of TCR affinity and correlated TCR sequence from primary human antigen-specific T cells using iTAST reveals a large range of TCR affinity on HCV precursor T cells that varies with age.
Siblings as therapists: a behavioral approach
Authors: N B Miller, D P Cantwell
Journal: American Journal of Psychiatry (1976)

Although many family therapy programs have taught behavior modification techniques to parents, few have involved siblings as therapeutic agents in the treatment of retarded, emotionally disturbed, or physically handicapped children. The authors describe their experiences with two families in which siblings were taught to use simple procedures to encourage desired behaviors in a disturbed brother or sister. They conclude that further investigation is needed to refine sibling training techniques and suggest that involvement in treatment programs may have beneficial influences on the normal siblings of disturbed children.
Realizing HOPE: The Ethics of Organ Transplantation From HIV-Positive Donors
Authors: Christine M. Durand, Dorry Segev, Jeremy Sugarman
Journal: Annals of Internal Medicine (2016)

The HIV Organ Policy Equity (HOPE) Act now allows transplantation of organs from HIV-positive living and deceased donors to HIV-positive individuals with end-stage organ disease in the United States. Although clinical experience with such transplants is limited to a small number of deceased-donor kidney transplants from HIV-positive to HIV-positive persons in South Africa, unprecedented HIV-positive-to-HIV-positive liver transplantations and living-donor kidney transplantations are also now on the horizon. Initially, all HIV-positive-to-HIV-positive transplantations will occur under research protocols with safeguards and criteria mandated by the National Institutes of Health. Nevertheless, this historic change brings ethical opportunities and challenges. For HIV-positive individuals needing an organ transplant, issues of access, risk, and consent must be considered. For potential HIV-positive donors, there are additional ethical challenges of privacy, fairness, and the right to donate. Careful consideration of the ethical issues involved is critical to the safe and appropriate evaluation of this novel approach to transplantation.
Early Indications for Exchange Transfusion in Hemolytic Disease of the Newborn
Authors: K POLACEK
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Oral S-adenosylmethionine in depression: a randomized, double-blind, placebo-controlled trial
Authors: B L Kagan, D L Sultzer, N Rosenlicht, R H Gerner
Journal: American Journal of Psychiatry (1990)

Methylation has been implicated in the etiology of psychiatric illness. Parenteral S-adenosylmethionine, a methyl group donor, has been shown to be an effective antidepressant. The authors studied the antidepressant effect of oral S-adenosylmethionine in a randomized, double-blind, placebo-controlled trial for 15 inpatients with major depression. The results suggest that oral S-adenosylmethionine is a safe, effective antidepressant with few side effects and a rapid onset of action. S-Adenosylmethionine induced mania in a patient with no history of mania. S-Adenosylmethionine may be useful for patients who cannot tolerate tricyclic anti-depressants. These findings support a role for methylation in the pathophysiology of depression.
Laboratory diagnosis of pemphigus: direct immunofluorescence remains the gold standard
Authors: F. Giurdanella, G.F.H. Diercks, M.F. Jonkman, H.H. Pas
Journal: British Journal of Dermatology (2016)

Pemphigus is a life-threatening autoimmune bullous disease that is characterized by intraepithelial blistering of skin and/or mucous membranes, by the in vivo deposition of immunoglobulin (Ig) G on the cell surface of keratinocytes and the presence of such IgG in the circulation(1) . This article is protected by copyright. All rights reserved.
Book Review Nelson Textbook of Pediatrics Fourteenth edition. Edited by Richard E. Behrman, with Robert M. Kliegman, Waldo E. Nelson, and Victor C. Vaughan III. 1965 pp., illustrated. Philadelphia, W.B. Saunders, 1992. $90. ISBN 0–7216–2976–8 .
Authors: Peter C. English
Journal: New England Journal of Medicine (1992)
Intraperitoneal chemotherapy: a review.
Authors: D E Brenner
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.7.1135 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3522820 Intraperitoneal chemotherapy: a review. D E BrennerxD E BrennerSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.7.1135 First Page PDF © 1986 by American Society of Clinical Oncology
Correlation between Serum Values of Prostatic Acid Phosphatase and Morphometric Analysis in the Cytologic Diagnosis of Prostatic Carcinoma
Authors: F Clar-Blanch, L Morell-Quadreny, B Fenollosa-Entrena, P Chuan-Nuez, M Gil-Salom, P Carretero-Gonzalez, A Llombart-Bosch
Journal: European Urology (1992)
HPA axis abnormalities in depressed patients with normal response to the DST
Authors: W Meller, R G Kathol, R S Jaeckle, P Grambsch, J F Lopez
Journal: American Journal of Psychiatry (1988)

In order to identify depressed patients with hypothalamic-pituitary-adrenal (HPA) axis abnormalities who have a normal response to the dexamethasone suppression test (DST), the authors administered a series of neuroendocrine tests including insulin-induced hypoglycemia, arginine vasopressin challenge, and a DST. Using standard sensitivity measures, as well as logistic regression, they concluded that many patients with HPA abnormalities are not identified by the DST. These findings suggest that other neuroendocrine tests, which are sensitive to HPA axis abnormalities, may be helpful in subtyping depression on the basis of HPA axis functioning.
Controversial 999 pilot ambulance trust chief executive resigns
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The chief executive of an ambulance trust that was criticised for deliberately delaying response times to patients’ emergency call outs and misreporting its own performance has resigned.

Paul Sutton has resigned from the South East Coast Ambulance Service NHS Foundation Trust it was confirmed on 31 May, after being on a “leave of absence” since March.

The trust provides 999 and NHS 111 emergency services to people in Surrey, Kent, and Sussex. In December 2014 it launched a pilot scheme to change standard operating procedures for …
THU0586 Ankylosing Spondylitis (AS) Self-Management Education Program – 6 Month Follow-Up Results
Authors: C.A. Inderjeeth, W. Raymond, C. Connor, J. Edelman, N. Cook, K. Briffa, J. McQuade
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Disease specific self-management interventions are rare. After a needs assessment, focus group discussions, and <i>Plan, Do, Study, Act</i> (PDSA) model we developed and tested the <i>Self Management for Ankylosing Spondylitis</i> (SMAS) program, for people with Ankylosing Spondylitis (AS). <h3>Objectives</h3> To examine the benefits of an SMSA program for people with AS regarding change in health status, quality of life, and disease activity. <h3>Methods</h3> 134 people were recruited in this case cohort intervention. Exclusion criteria: &lt;18yo; non-English speaking; co-morbid inflammatory musculoskeletal disease; and/or visual, auditory, or cognitive impairment. Participants attended a weekly 2.5 hour self-management education session facilitated by same two health professionals over 6 weeks. The scripted content included multidimensional strategies including stretches; and optional 7th week supervised exercise class. Demographic, AS disease management characteristics, medication patterns, and outcomes were measured at baseline, 6 weeks, 3 and 6 months using repeated measures ANOVA for: back pain (VAS), fatigue (MAF), anxiety and depression (HAD), health distress (HDq), fatigue severity scale (FSS), pain self-efficacy (PSEQ), quality of life (SF-36) and Evaluating Ankylosing Spondylitis Qol (EASIQol), global perceived health (GPH), patients disease global assessment (PDGA). AS outcomes were analysed using repeated measures ANOVA for: Bath Ankylosing Spondylitis – Global, Disease Activity Index, and Functional Index (BAS-G, BASDAI, &amp; BASFI), and Ankylosing Spondylitis QoL (ASQol). <h3>Results</h3> At baseline, 43.3% were male, and the mean age was 47.2±15.1 years. The median time to AS diagnosis from the index symptom experience was 3 years with an IQR (1-6). The BAS-G improved between baseline and 3 months (p=0.011) and were sustained at 6 months (p=0.039). The BASDAI improved between baseline and 3 months (p=0.01) and were sustained at 6 months (p=0.009). The ASQol improved between baseline and 6 months (p=0.051). A positive trend were seen for the MAFs GFI, back pain (i.e. nocturnal and total), and the PDGA over the 6 months although these trends were not statistically significant. The composite SF-36 (physical and mental), HADs, HDq, FSS, composite Easiqol (physical, disease activity, wellbeing, and social), PSEQ demonstrated no improvement over the study. There was no significant change in medication usage over the 6 months. <h3>Conclusions</h3> SMAS for AS is independently effective in improving AS specific Disease activity, but global QOL scores did not change. <h3>References</h3> Von Korff M, Glasgow RE, Sharpe M. Organising care for chronic illness. BMJ 2002;325:92-94. Zochling J. Measures of symptoms and disease status in ankylosing spondylitis. Arthritis Care Res 2011;63:S47-S58. <h3>Disclosure of Interest</h3> None declared
Aflatoxin B 1 : Specific Antibodies and Their Use in Radioimmunoassay 2 3
Authors: John J. Langone, Helen Van Vunakis
Journal: JNCI Journal of the National Cancer Institute (1976)

New Zealand White rabbits immunized with covalent conjugates prepared from polylysine and the O-carboxymethyloxime derivatives of either aflatoxin B1 (AFB1) or an analogue, 5,7-dimethoxycyclopentenon (2,3-c)coumarin, produced antibodies that bind 3H-AFB1. The specificities of the antisera with respect to aflatoxins B2, B2a, G1, G2, Q1, P1, and some other structurally related compounds were determined. Radioimmunoassays that can detect levels as low as 0.27 pmoles (0.06 ng) of AFB1 were used to analyze serum, urine, and crude extracts of corn and peanut butter supplemented with aflatoxin. In the foodstuffs, as little as 1 µg AFB1/kg was measured. The immunoassay was at least as sensitive and specific as other available analytic methods, but did not require the purification of samples by chromatography before analysis. The technique may be particularly useful in epidemiologic studies designed to study the possible relationship between chronic anatoxin ingestion and cancer.