tbuckley/cabot-search huggingface dataset:
The dexamethasone suppression test in newly hospitalized schizophrenic patients
Authors: M I Herz, G A Fava, G Molnar, L Edwards
Journal: American Journal of Psychiatry (1985)

Of 15 unmedicated chronic schizophrenic patients with acute exacerbations and 15 healthy controls given the dexamethasone suppression test (DST), 11 patients and two controls were nonsuppressors. The results add to the evidence that the DST has limited value in psychiatric diagnosis.
AB1196 The Effect of Rehabilitation Guidlines on Improvment of Activity of Daily Living (ADL) in Female Rheumatoid Arthritis Patiets with Hand and Wrist
Authors: E.M. Abda, H.K. Abdel-Elaal, Z.A. E.-L. Mohamed, Z.I. Selim
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) is the most common inflammatory polyarthritis It can cause persistent joint pain, joint damage and long-term disability (especially in the hands and feet).The overall goals of management are to prevent or control joint damage, maximize function and decrease pain. The Quasi- experimental study <h3>Objectives</h3> To assess patient9s knowledge and practices in relation to disease and degree of self- care activities before the implementation of rehabilitation guideline and evaluate the effect of rehabilitation guideline on patient9s knowledge and practice as well as on improving the activity of daily living (ADL) of patients. <h3>Methods</h3> Patients from rheumatology department and rheumatology outpatient clinic of Assiut University Hospital. Twenty five female patients with RA, The collection of data was achieved by using three tools, <i>tool(1)</i> The Health Assessment Questionnaire (HAQ) include three parts, <i>part1</i>, include socio-demographic data about patient; <i>part 2</i> Assessment of patient9s knowledge and practice regarding RA, and <i>part3</i>, Assessment the effect of RA on ability of patient to function in activity daily living (ADL), <i>tool(2)</i>, Michigan Hand outcome Questionnaire. <i>tool(3)</i> suggested measure for hand grip strength (GST-2013®). <h3>Results</h3> The results of the study showed that there were highly significant statistical improvement (p&lt;0.001) were noticed regarding knowledge about RA, and highly significant improvement regarding to total scores of common daily activity (z ≤2.58**). There were highly significant improvement related to over hand function, work performance and hands/wrist problem interference especially related to pain there were highly significant improvement (z=6.4, 4.8) in post 1 and post 2. <h3>Conclusions</h3> Based on the finding of the study might be improve treatment in RA by manipulation of education program regarding medication, nutritional counseling, physical exercises and joint protection. <h3>Disclosure of Interest</h3> None declared
Activation of the <i>ras</i> <sup>Ha</sup> Gene in Urethane-Initiated Papillomas Induced by Protocols with High and Low Frequencies of Malignant Conversion
Authors: Henry Hennings, Victor A. Robinson, Stuart H. Yuspa, David J. Welty, David G. Greenhalgh
Journal: Cancer Communications (1991)

The number of papillomas that develop in mice initiated with a single exposure to urethane and promoted by repeated applications of 12-O-tetradecanoylphorbol-13-acetate (TPA) is increased greater than 4-fold by pretreating the skin once with TPA 24 hr before administration of urethane. In contrast, the carcinoma incidence was increased only 2-fold by the TPA pretreatment. Individual papillomas developed from the two protocols, differing in the potential for conversion to malignancy, were compared for activation of the rasHa gene. An activated oncogene that transformed 3T3 cells was found in the DNA of four of five papillomas from urethane-initiated, TPA-promoted mice and in eight of eleven papillomas from similarly promoted mice exposed to TPA before urethane initiation. Southern analysis of DNA from tumors or 3T3 foci demonstrated that the rasHa gene was activated by an A----T transversion at the second base of codon 61 in all mutated alleles. Thus, tumors induced by the two protocols did not differ in rasHa activation.
PTH-294 Missed diagnosis of bowel cancer in surgical outpatients – to refer or not to refer for whole colonic imaging? a 22-year study of 29005 patients: Abstract PTH-294 Table 1
Authors: MR Thompson, K Flashman, D O’Leary, A Senapati
Journal: Gut (2015)

<h3>Introduction</h3> Little is known about the rates or reasons for missing diagnosis of bowel cancer in outpatients. This study determined the number of missed cancers by flexible sigmoidoscopy (FS), barium enema (BE), colonoscopy, CT colonography (CT) and in patients not having whole colonic imaging (WCI) after a normal FS. <h3>Method</h3> Retrospective cohort analysis using clinical data collected prospectively for 22 years (1986–2007) in a colorectal outpatient clinic in Portsmouth. 29005 patients were analysed. Missed cancers were detected by referral back to clinic, local audit for NBOCAP and comparison with the regional Cancer Registry. <h3>Results</h3> 1626 patients had bowel cancer. 66.1% (19174/29005) of all patients in the study did not have WCI. 13.8% (3993) had colonoscopy, 17.9% (5206) had BE and 883 (latter 8 years) had CT. 3.9% (63/1626) of cancers were missed; 21 distal (rectum and sigmoid), 41 proximal and 1 unknown site. 1.6% (21/1333) or 1:63 of distal cancers were missed by FS. Twenty-one of all missed cancers were subsequently diagnosed within 1 year (50–358 days) of the outpatient clinic, twenty within 1–2 years and twenty-two between 2–3 years. Twenty-two proximal cancers were subsequently diagnosed with cancer after a normal FS and no WCI, which means the incidence of cancer in this group of patients was 0.1% (22/18252). <h3>Conclusion</h3> A policy of outpatient FS with selective WCI resulted in a low rate of missed cancers. The replacement of BE by Colonoscopy and CT should greatly reduce the numbers of missed cancers in those having WCI. Strict diagnostic strategies are required to avoid excessive delay in diagnosis of the few with cancer without over investigation of patients with transient symptoms from benign disease. <h3>Disclosure of interest</h3> None Declared.
Cytological Changes Following Roentgen Irradiation of the Liver in Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Wilson, Margaret E., Stowell, Robert E.
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Cytological Changes Following Roentgen Irradiation of the Liver in Mice Get access Margaret E. Wilson, Margaret E. Wilson Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert E. Stowell Robert E. Stowell Department of Pathology and Oncology, University of Kansas Medical School, Kansas City, Kans. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 5, April 1953, Pages 1123–1137, https://doi.org/10.1093/jnci/13.5.1123 Published: 01 April 1953 Article history Received: 06 October 1952 Published: 01 April 1953
GATA2 regulates dendritic cell differentiation
Authors: Koichi Onodera, Tohru Fujiwara, Yasushi Onishi, Ari Itoh-Nakadai, Yoko Okitsu, Noriko Fukuhara, Kenichi Ishizawa, Ritsuko Shimizu, Masayuki Yamamoto, Hideo Harigae
Journal: Blood (2016)
Stem Cell Mechanobiology: 3D Micropillars Guide the Mechanobiology of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (Adv. Healthcare Mater. 3/2016)
Authors: Raghavendra Palankar, Michael Glaubitz, Ulrike Martens, Nikolay Medvedev, Marvin von der Ehe, Stephan B. Felix, Markus Münzenberg, Mihaela Delcea
Journal: Advanced Healthcare Materials (2016)

On page 335, M. Münzenberg, M. Delcea, and co-workers report on the use of 3D micropillars generated by photolithography as a platform to probe by atomic force microscopy the mechanodynamics of human induced pluripotent stem cell-derived cardiomyocytes. The results indicate that 3D micropillars guide subcellular cytoskeletal modifications of cardiomyocytes and lead to biochemical changes altering beating rate, stiffness, and calcium dynamics of the cells.
A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity
Authors: Zhijian He, Xiaomeng Wan, Anita Schulz, Herdis Bludau, Marina A. Dobrovolskaia, Stephan T. Stern, Stephanie A. Montgomery, Hong Yuan, Zibo Li, Daria Alakhova, Marina Sokolsky, David B. Darr, Charles M. Perou, Rainer Jordan, Robert Luxenhofer, Alexander V. Kabanov
Journal: Biomaterials (2016)
On Smell
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1980)

The vacuum cleaner turned on in the apartment's back bedroom emits a high-pitched lament indistinguishable from the steam alarm on the tea kettle in the kitchen, and the only way of judging whether to run to the stove is to consult one's watch: there is a time of day for the vacuum cleaner, another time for the tea kettle. The telephone in the guest bedroom sounds like the backdoor bell, so you wait for the second or third ring before moving. There is a random crunching sound in the vicinity of the front door, resembling an assemblage of people excitedly . . .
SAT0056 Retro – Study of Reduction of Therapy in Patients with Rheumatoid Arthritis in Ongoing Remission
Authors: J. Haschka, M. Englbrecht, A.J. Hueber, B. Manger, A. Kleyer, M. Reiser, S. Finzel, H.-P. Tony, S. Kleinert, M. Feuchtenberger, M. Fleck, K. Manger, W. Ochs, M. Schmitt-Haendle, J. Wendler, F. Schuch, M. Ronneberger, H.-M. Lorenz, H. Nuesslein, R. Alten, W. Demary, J. Henes, G. Schett, J. Rech
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Due to improved therapeutic management a steadily increasing number of rheumatoid arthritis (RA) patients reach stable remission of disease. Data on withdrawal of medication after sustained remission are limited, though it is important for economic and safety reasons. The RETRO study represents a real-life study addressing different strategies of reduction of DMARD therapy in RA patients in stable disease remission. <h3>Objectives</h3> To prospectively analyze the risk for disease relapses in rheumatoid arthritis (RA) patients in sustained remission, either continuing, tapering, or stopping disease modifying anti-rheumatic drugs (DMARD). <h3>Methods</h3> RETRO is a phase 3, multicenter, randomized, controlled, open, prospective, parallel-group trial (EudraCT Number: 2009-015740-42). Patients, fulfilling the ACR/EULAR2010 criteria for RA were enrolled into the study if they were in clinical remission (DAS28-ESR &lt;2.6).Patients on ≥1 conventional and/or biological DMARDs were included and randomized into three treatment arms: Arm 1 (control group) was continuing full-dose conventional and/or biological DMARD treatment; arm 2 was reducing the dose of all conventional and/or biological DMARD treatment by 50% and arm 3 was reducing the dose of all conventional and/or biological DMARD treatment by 50% for 6 months before entirely stopping DMARD. In case of recurrence of disease (DAS &gt;2.6) the original therapy was restarted. <h3>Results</h3> 101 patients (61.4% females, 60% ACPA positive, 63% RF positive; 37.6% biologic therapy, 80.2% MTX, 7.9% other DMARDs) finished the one year endpoint: 38 patients in arm 1 (age 55.8±13.9y, disease duration 6.8±5.9y, remission 20.9±16.7mo), 36 patients in arm 2 (age 54.1±13.1y, disease duration 8.6±7.7y, remission 14.5±12.7mo) and 27 patients in arm 3 (age 54.8±12.3y, disease duration 5.6±7.0y, remission 17.6±19.5mo). Of 101 patients, 66.3% were still in remission at 12 mo. Significantly more patients flared in reduction arm 2 (38.9%, c<sup>2</sup>(1)=5.0, p=0.036) and arm 3 (51.9%, c<sup>2</sup>(1)=9.6, p=0.003) compared to control arm 1 (15.8%), while there was no significant difference between the two reduction arms (c<sup>2</sup>(1)=1.1, p=0.443). With multivariate logistic regression ACPA positivity (p=0.03) and treatment reduction (arm2 p=0.01, arm3 p=0.003) were detected as predictors for flares. <h3>Conclusions</h3> This study is a prospective real life treatment strategy study investigating the effect of reduction and discontinuation of DMARD therapy in RA patients in stable remission. Presence of ACPA but not RF was the only predictor for recurrence of disease. <h3>Disclosure of Interest</h3> None declared
EEG sleep evaluation of depression in borderline patients
Authors: E McNamara, C F Reynolds, P H Soloff, R Mathias, A Rossi, D Spiker, P A Coble, D J Kupfer
Journal: American Journal of Psychiatry (1984)

In this study the sleep of borderline patients and patients with primary nondelusional depression showed sleep continuity disturbance and greater REM activity and density (particularly during the first REM period) than that of normal control subjects. First-night REM latencies were more variable in the borderline than in the depressed group, but by the second night both groups showed shorter REM latencies than the controls. The similarities in EEG sleep suggest a relationship between borderline disorder and the affective spectrum and cast doubt on the definition of the borderline disorder as a pure character type.
Long-Term Tissue Culture of Neuroblastomas
Authors: Milton N. Goldstein, Donald Pinkel
Journal: JNCI Journal of the National Cancer Institute (1958)

Long-Term Tissue Culture of Neuroblastomas Get access Milton N. Goldstein, Milton N. Goldstein Departments of Biology and Pediatrics, Roswell Park Memorial Institute, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald Pinkel Donald Pinkel Departments of Biology and Pediatrics, Roswell Park Memorial Institute, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 4, April 1958, Pages 675–688, https://doi.org/10.1093/jnci/20.4.675 Published: 01 April 1958 Article history Received: 16 August 1957 Published: 01 April 1958
SHANK3 controls maturation of social reward circuits in the VTA
Authors: Sebastiano Bariselli, Stamatina Tzanoulinou, Christelle Glangetas, Clément Prévost-Solié, Luca Pucci, Joanna Viguié, Paola Bezzi, Eoin C O'Connor, François Georges, Christian Lüscher, Camilla Bellone
Journal: Nature Neuroscience (2016)
High-dose chemotherapy with ABMT for metastatic breast cancer.
Authors: M Martin
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.10.1653 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1403046 High-dose chemotherapy with ABMT for metastatic breast cancer. M MartinxM MartinSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.10.1653 PDF "High-dose chemotherapy with ABMT for metastatic breast cancer.." Journal of Clinical Oncology, 10(10), pp. 1653–1654© 1992 by American Society of Clinical Oncology
AB0123 Real-Time in Vivo Apoptosis Imaging with a Histone-H1 Targeting Probe for the Measurement of therapeutic Response in an Experimental Arthritis Model
Authors: J.W. Hong, S. Sung, A.F. Hasan, M.J. Jung, J.S. Eun, N. Kim, E.J. Nam, Y.M. Kang
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Apoptosis is a well-organized process that is an important and active regulatory pathway of cell infiltration within inflammatory tissues. Decision on response after treatment with disease modifying anti-rheumatic drugs in rheumatoid arthritis has been performed by measuring acute phase reactants and clinical parameters such as disease activity score (DAS). Real-time monitoring of apoptosis may improve our decision on the response to therapy. <h3>Objectives</h3> To examine whether in vivo imaging of apoptosis obtained by uptake of Histone H1-targeting probe labeled with near-infrared fluorescence is able to detect early response and monitor quantitative changes after treatment in a chronic inflammatory arthritis model. <h3>Methods</h3> Histone H1-targeting probe (CQRPPRC, ApoPep-1) was synthesized using HPLC and labeled with FPR675 near infrared fluorescence dye. To induce apoptosis, cells were treated with staurosporine (STS) or methotrexate (MTX). Apoptotic cells were measured using flow cytometer and confocal microscopy. For in vivo imaging, collagen-induced arthritis (CIA) model was treated with drugs and optical imaging was performed using OpTix Explore. Total photon count (TPC) was measured by the summation of photon counts from the region of interests of four paws. <h3>Results</h3> Treatment of Jurkat T cells and THP-1 cells with STS and MTX induced apoptosis in a dose-dependent manner, which was detected by binding with ApoPep-1-FITC or annexin V-FITC in combination with propodium iodide in a similar sensitivity. Detection of apoptotic cells using ApoPep-1-FITC within sections of joint tissues from active CIA mice was as effective as that using tunnel assay. In active CIA mice, apoptosis imaging was performed using either annexing V or ApoPep-1 labeled with FPR675 (5 mg/kg, each), which showed a marked enhancement of TPC in ApoPep-1 imaging upto 8 hours after intravenous (i.v.) injection (Figure). According to the stage of disease progression, optical intensity of ApoPep-1-FPR675 was significantly increased compared to that of annexin V-FPR675 from the early stage of arthritis, which showed the most conspicuous difference in active arthritis. After treatment with high dose of MTX (50mg/kg, i.v.), the difference of TPC was greatest after 3 days of treatment compared with control-treated mice. The number of apoptotic cells detected using ApoPep-1-FITC within tissue sections from the joints was significantly increased after treatment with high dose of MTX. <h3>Conclusions</h3> The present data indicate that in vivo apoptosis imaging with ApoPep-1 is a sensitive tool for early decision on therapeutic response after DMARDs treatment in chronic inflammatory arthritis. Further study is warranted to elucidate the application of this radiation-free imaging tool for human disease. <h3>Disclosure of Interest</h3> None declared
SAT0213 Hypocomplementemia During Tocilizumab Treatment for Rheumatoid Arthritis:Long Term Follow-Up Results
Authors: Y. Braun-Moscovici, M. Braun, D. Markovits, A. Balbir-Gurman
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hypocomplementemia was previously reported in patients (pts) with rheumatoid arthritis (RA) treated with tocilizumab (TCZ). Decreased complement (C3,C4) production was suggested as a possible mechanism. The long-term consequences concerning serious bacterial infections or autoimmune disorders (AID) have not been reported. <h3>Objectives</h3> To assess the long-term outcome of RA pts treated with TCZ who developed hypocomplementemia regarding serious bacterial infections or AID. <h3>Methods</h3> The charts of RA pts treated with TCZ at our center were reviewed retrospectively. Data regarding pts9 age, gender, disease duration, presence of rheumatoid factor (RF), antibodies to citrullinated peptide (ACPA), and nuclear antigens (ANA), previous and concomitant non-biological DMARDs, previous biological DMARDs, and TCZ treatment duration; laboratory parameters including leucocytes and thrombocytes count, liver enzymes, C3 and C4 levels at baseline and during TCZ treatment; episodes of infections, allergic reactions, and AID were captured and analyzed. <h3>Results</h3> Thirty five pts out of 85 RA pts treated with TCZ, at our center, had serial measurements of serum complement concentration. Fourteen pts (mean age 58.3 years, mean disease duration 8.6 years) developed low C4 levels (9 had also low C3). Mean TCZ treatment period was 4.6 years (range 1-10 years). All patients had normal complement levels at baseline. Seven pts developed persistent leukopenia, 3 pts had persistent thrombocytopenia, 3 pts developed liver enzymes elevation. No serious bacterial infections or new onset AID occurred during follow up. One patient developed a severe allergic reaction. Persistent leukopenia was observed only in 2 out of 21 pts with normal complement levels, as opposed to 5 out of 14 pts with hypocomplementemia. No patients with normal complement levels developed thrombocytopenia. No significant differences regarding previous biologic or concomitant DMARD9s treatment were found between the 2 groups of pts. <h3>Conclusions</h3> Long-term follow up of RA pts treated with TCZ who developed hypocomplementemia did not reveal an increased rate of serious bacterial infections or AID. Persistent leukopenia and thrombocytopenia were frequent in these pts; the relationship to hypocomplementemia needs to be further elucidated. <h3>Disclosure of Interest</h3> None declared
Oligodeoxynucleotides antisense to c-abl specifically inhibit entry into S-phase of CD34+ hematopoietic cells and their differentiation to granulocyte-macrophage progenitors
Authors: V Rosti, G Bergamaschi, C Lucotti, M Danova, C Carlo-Stella, F Locatelli, L Tonon, G Mazzini, M Cazzola
Journal: Blood (1995)
Fabrica
Authors: John Beard
Journal: BMJ (2008)

In the early 16th century anatomy became an increasingly important component of a doctor’s learning. The Renaissance brought with it an influx of newly translated Galenic texts (including large anatomical guides), and these helped to enhance this fashionable area of study. In addition there emerged an emphasis on physicians doing dissection themselves—seeing with their own eyes what parts of the body look like. The foremost exponent of this practical, hands-on approach was Andreas Vesalius.

Born in Brussels in 1514, Vesalius was the son of an apothecary. He studied medicine at Paris, where he was educated in the teachings of Galen, before being appointed to a lectureship in surgery and anatomy at Padua. He was 23 years old. In 1540 Vesalius utilised Renaissance ideas surrounding anatomy to begin work on his definitive treatise. The result, in 1543, was De humani corporis fabrica (On the Workings of the Human Body, or “the Fabrica”), which the Oxford Medical Companion describes as “probably the most influential of all medical works.”

Before the Fabrica there had for some time been a dearth of accurate anatomical illustration. The standard procedure was for anatomists to employ artists to do illustrations under their instruction. Invariably the anatomists would guide their depiction in the vein of traditional images rather than direct observation, thereby retaining longstanding inaccuracies.

Three factors can be seen as accounting for the Fabrica’s outstanding anatomical content: Vesalius’s brilliant technical skill with the scalpel, his insistence on using as evidence only that which he had observed, and his copious knowledge of the Galenic corpus. Hence it can be appreciated that the Fabrica, when published, set the standard in anatomical illustration. The quality of the book’s artwork is such that it has, arguably, received more attention than the textual content. Not only are the drawings highly accurate, they also evince an outstanding level of artistic skill—the artist is thought to have been a pupil of Titian.

Of central importance is Vesalius’s treatment of Galenic anatomy. Although much of the content of the Fabrica remains true to Galen, Vesalius was also keen to highlight the inaccuracies and shortcomings of the Greek physician. Galen had used animals, often apes, as his anatomical subjects, and as a result there were several errors, for example in the depiction of the heart’s chambers, that Vesalius looked to rectify.

Reaction to the publication of the Fabrica could have been easily predicted. Vesalius would have known the controversy that his book’s attack on Galen would cause and, most likely, would have welcomed it in the knowledge that it would add to his publicity. The text was groundbreaking in its anatomical content, and its innovative illustrations and modes of presentation were also novel. Ultimately the Fabrica helped to advance the career of Vesalius—he became household physician to Emperor Charles V.