tbuckley/cabot-search huggingface dataset:
UTILIDAD EN LA CLÍNICA DIARIA DE LA CITOLOGIA POR PUNCION MEDIANTE USE EN LOS TUMORES SOLIDOS DEL PÁNCREAS. INFLUENCIA DE LA TÉCNICA DE PUNCIÓN
Authors: R Castillo Trujillo, S Maestro Antolin, JL Da Cruz Soares, K De Jesus Geneaux, A Pérez Millán, F Igea Arisqueta
Journal: Endoscopy (2011)

Introducción: Los estudios tradicionales de certeza diagnostica (Sensibilidad, especifidad, VP+ y VP-) son difícil aplicación en el campo de la citología pancreática mediante USE PAAF. Los informes de los patólogos en la práctica habitual incluyen ocasionalmente frases ambiguas del tipo: "intensa atipia reactiva aconsejamos biopsia según sospecha clínica", "atipia moderada-severa repetir si persiste sospecha" etc que no permiten tomar decisiones clínicas apoyados en ellos ni encuadrar los resultados de la prueba como positivos o negativos. En este contexto es difícil realizar estudios tradicionales retrospectivos para valorar la utilidad de la citología en nuestra práctica clínica diaria. Por ello nos planteamos este estudio con el siguiente
Book: Elsie Inglis
Authors: M. Tenant-Flowers
Journal: BMJ (1999)

Leah Leneman NMS Publishing, £5.99, pp 94 ISBN 1 901663 09 4 ——————— Rating: ![Graphic][1]</img>![Graphic][2]</img> “My good lady, go home and sit still,” was the rebuff issued to Dr Elsie Inglis, licentiate of the Royal Colleges of Glasgow and Edinburgh, with 16 years of hospital experience behind her, when she offered her services to the Royal Army Medical Corps at the outbreak of the first world war. As … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif
Abstract 1205: Circulating micro-RNAs can detect adaptive response to therapy and aggressive subset of prostate cancer.
Authors: Ana M. Aparicio, Emily Gallichotte, Heather Cheng, Suk-Young Yoo, Sankar Maity, Christopher Logothetis, Muneesh Tewari
Journal: Cancer Research (2013)

Abstract Circulating markers that inform of the adaptive biology and the clinical virulence of prostate cancer do not exist. Small cell carcinoma of the prostate (SCPC) is an aggressive, androgen receptor (AR)-negative, morphological variant that arises often during the castration-resistant progression of typical adenocarcinoma. Its presence is associated with a poor response to hormonal therapies and predicts for a short survival. Micro-RNAs (miRNAs) regulate a range of processes, including establishment and maintenance of tissue differentiation, and are well-preserved in serum. Based on the observation that SCPC are characterized by a loss of prostate epithelial marker expression (such as AR and HOXB13) and an increase in the expression of proneural transcription factors (such as MYCN and ASCL1) we formulated the hypothesis that the SCPC display a miRNA profile distinct from that of typical AR-driven prostate carcinomas. We profiled the miR extracted from the serum samples of 13 men with biopsy-proven SCPC, and of 9 men with bone-predominant metastatic CRPC. Because SCPC is associated with large tumor burdens, we selected patients with bone-predominant CRPC that had abnormally high alkaline phosphatase levels and PSA &amp;gt; 20ng/mL. 322 miR were detected in at least one of the 22 samples. We identified two miR that were present in 10 and 11 of 13 (77% and 85%) patients with SCPC and 3 and 1 of 9 (33% and 11%) of men with unselected typical bone-predominant CRPC. Both of these miRs have been shown to control multiple genes regulating neuronal differentiation and to induce the conversion of human fibroblasts into neurons, a mechanism which may be shared by prostate adenocarcinoma cells in their transdifferentiation to small cell prostate cancer cells. Moreover, one of them was recently shown to silence AR expression. Therefore we conclude that two circulating miRs may serve to monitor adaptive responses and identify virulent subsets of prostate cancer, thus serving to guide therapy and selection of patients for clinical trials. Validation of these findings is ongoing in a larger cohort of patients. Citation Format: Ana M. Aparicio, Emily Gallichotte, Heather Cheng, Suk-Young Yoo, Sankar Maity, Christopher Logothetis, Muneesh Tewari. Circulating micro-RNAs can detect adaptive response to therapy and aggressive subset of prostate cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1205. doi:10.1158/1538-7445.AM2013-1205
Apport diagnostique de la vidéocapsule endoscopique dans la maladie coeliaque compliquée
Authors: M Barret, G Malamut, G Rahmi, E Samaha, J Edery, V Verkarre, E Macintyre, E Lenain, R Jian, G Chatellier, N Cerf-Bensussan, C Cellier
Journal: Endoscopy (2012)

L'intérêt de la vidéocapsule endoscopique (VCE) dans la maladie coeliaque résistante au régime sans gluten reste mal évalué. Le but du travail était d'isoler des facteurs d'orientation diagnostique permettant de distinguer les sprues réfractaires de type I (SRI) des sprues réfractaires de type II (SRII), clonales et avec phénotype anormal des lymphocytes intraépithéliaux.
OP0188-PC Pain trajectories in hip osteoarthritis: Results of the dutch cohort hip and cohort knee (CHECK)
Authors: S.P. Verkleij, P.A. Luijsterburg, J. Wesseling, A.N. Bastick, B.W. Koes, S.M. Bierma-Zeinstra
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Pain is the most important complaint reported in osteoarthritis (OA). In hip OA, a recent study showed five distinctive trajectories of pain over a two year follow-up period.[1] The next step is to validate these finding in another study population with a longer follow-up period. <h3>Objectives</h3> To identify long term trajectories of persons with hip pain due to OA over a 5-year follow-up period. <h3>Methods</h3> Data from the inception cohort CHECK[2] was used to investigate the course of pain. For this study 208 participants were included who fulfilled the clinical and/or radiographic American College of Rheumatology (ACR) criteria for hip OA. Participants filled out yearly questionnaires during the 5-year follow-up period. Pain severity was measured by an 11-point numeric rating scale (0=no pain;10=unbearable). Latent class growth analysis (LCGA) was used to determine the number of different trajectories of participants with hip pain due to OA. Multinomial regression analysis was used to predict the effect of baseline characteristics of the participants and the probability of membership to a one of the trajectories. <h3>Results</h3> Analyses yielded 4 distinctive trajectories of pain during the five year follow-up instead of five trajectories in another study sample over two years of follow-up. Participants within trajectory 1 ("mild pain"; n=78) fluctuated slightly within ranges of mild pain. Trajectory 2 ("moderate pain"; n=76) consists of participants who slowly increased within ranges of moderate pain over the 5-year period. Trajectory 3 ("decreasing pain"; n=22) comprised participants who started with severe pain at baseline, but after 5-years their pain decreased. Participants within trajectory 4 ("always pain"; n=32) had constant levels of severe pain. Compared with the "mild pain" group, participants in the "moderate pain" group have a higher body mass index (BMI), more often have morning stiffness of the hip, a decreased hip flexion, and concurrent knee complaints. Participants in the "always pain" group are more likely to be women. <h3>Conclusions</h3> LCGA identified 4 distinct trajectories in 208 participants with clinically and/or radiographic determined hip OA. Predictors for membership to the "moderate pain" group were BMI, morning stiffness of the hip, decreased hip flexion, and concurrent knee pain. For the "always pain" group this was gender. <h3>References</h3> Verkleij SPJ, Hoekstra T, Rozendaal RM, Waarsing JH, Koes BW, Luijsterburg PAJ, Bierma-Zeinstra SMA. Defining discriminative pain trajectories in hip osteoarthritis over a two-year time period. Ann Rheum Dis 2012. Wesseling J et al. CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative. Ann Rheum Dis 2009;68:1413-9. <h3>Disclosure of Interest</h3> None Declared
LEFT ATRIAL VOLUME DETERMINED BY CMR IS AN INDEPENDENT PREDICTOR OF INCIDENT ADVERSE CARDIOVASCULAR EVENTS: THE FRAMINGHAM HEART STUDY
Authors: Saadia Qazi, Philimon Gona, Garima Arora, Carol Salton, David McManus, Christopher O’Donnell, Warren Manning, Michael Chuang
Journal: Journal of the American College of Cardiology (2016)
Recent high death rates in older people are not exceptional, says Public Health England
Authors: N. Hawkes
Journal: BMJ (2013)

Public Health England has said that excess mortality in elderly people recorded in 2012-13 did not need any new explanation and was largely due to influenza and cold weather.

In a letter and new report sent to leading public health practitioners,1 John Newton, Public Health England’s chief knowledge officer, said that an earlier analysis had “potential methodological weaknesses” and did not add anything to work already being carried out elsewhere in the …
NATIONAL TRENDS OF PCI AND CONCURRENT MORTALITY IN PATIENTS ≥75 YEARS AGE HOSPITALIZED DUE TO ACUTE MYOCARDIAL INFARCTION
Authors: Bhavi Pandya, Sainath Gaddam, Achint Patel, Neil Patel, Parisha Bhatia, Donald McCord, Roman Royzman, Ruben Kandov, James Lafferty
Journal: Journal of the American College of Cardiology (2016)
Abstract 1001: Effects of matrix compositions on the development of breast acini and ducts in a 3D in-vitro culture model
Authors: Muthulekha Swamydas, Jill Eddy, Karen L. Burg, Didier Dréau
Journal: Cancer Research (2010)

Abstract Background: Epithelial cells of the breast respond to cues from the stromal components and develop into polarized and highly organized functional acinar and ductal structures. Extracellular matrix components and increased stiffness in particular have been shown to promote breast cancer. The stroma - cell interactions that determine the cellular organization and differentiation are in part reproduced in a 3D environment. Whether alterations of the microenvironment in 3D cultures could mimic phenotypic alterations observed during breast cancer progression remain to be fully determined. Here we present the effects of various stroma physical compositions on the ability of heterotypic 3D cultures of epithelial and mesenchymal stem cells to organize into acinar and tubular structures. Material &amp; Methods: The normal murine mammary gland (NMuMG) cells were cultured either alone or in combination (30:70) with mouse mesenchymal stem cells (D1), in 3D cell culture conditions generated by agarose, collagen and Matrigel® alone or a combination thereof. After 3-5 days in culture, cell distribution, organization and the presence of acinus-like and tubule-like structures were determined. Results: By immunohistochemistry, NMuMG cells co-cultured with D1 cells were shown to form acinar structures with the NMuMG epithelial cells surrounding a lumen composed of dead cells whereas the D1 cells were mostly peripheral. Immuno-staining for laminin indicated the presence of basement membrane when NMuMG cells were grown in Matrigel® alone or co-cultured with D1 cells in a combination of Matrigel® and collagen I. The number of acinar structures was significantly higher in cultures grown in combination of agarose with Matrigel® or collagen I when compared to the cultures grown in Matrigel® or collagen I alone (P&amp;lt;0.05). No tubular structures were formed when agarose was included in the matrix, regardless of the combination. In Matrigel® but not in collagen I/ Matrigel® microenvironment the number of tubular structures was significantly increased in NMuMG /D1 co-culture when compared to culture of NMuMG cells alone (P&amp;lt;0.05). Conclusion: These results indicate that the physical and biochemical properties of the matrix and cellular composition alter the organization of the mammary gland. Furthermore, they underline the likely critical role of the extracellular matrix in breast cancer progression. Supported by grants from the Department of Defense Era of Hope Program and the National Science Foundation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1001.
TCTAP A-123 Mitral Loop Cerclage (MLC) as a Variant form of ‘Miral Cerclage Annuloplasty’ by Adding an Appliance (CSTV) for Preventing Its Potential Complications: A Preclinical Study with Mature Devices
Authors: June Hong Kim, Min-Ku Chon, Sanghyun Lee, Soo-Yong Lee, Hyng-Gon Je, Ki-Seok Choo, Jongmin Hwang, Jeong Su Kim, Kook-Jin Chun, Si-Chan Sung
Journal: Journal of the American College of Cardiology (2015)
Management of type 2 diabetes in adults: summary of updated NICE guidance
Authors: Hugh McGuire, Damien Longson, Amanda Adler, Andrew Farmer, Ian Lewin
Journal: BMJ (2016)

#### What you need to know New evidence and developments regarding the management of blood glucose levels, antiplatelet therapy, and erectile dysfunction prompted this update of the 2009 guidance. There were safety concerns surrounding some blood glucose lowering medicines, new evidence on new dipeptidyl peptidase-4 (DPP-4) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists, new indications and combinations for licensed drugs, and the potential impact of drugs coming off patent on health and economic issues. New evidence and safety issues relating to the off label use of antiplatelet therapy (aspirin and clopidogrel) in the primary prevention of cardiovascular disease were also considered. Type 2 diabetes affects 6% of the UK population1 and is commonly associated with obesity, physical inactivity, raised blood pressure, and disturbed blood lipid levels. It causes long term microvascular and macrovascular complications, plus reduced quality of life and life expectancy. The management of diabetes is complex and needs to address the prevention of cardiovascular disease and microvascular disease and the detection and management of early vascular complications. This article summarises the most recent recommendations from the National Institute for Health and Care Excellence (NICE),2 recently updated due to the availability of new evidence and developments. The article also summarises a selection of recommendations which still stand. #### What's new in this guidance
SP0106 MASCULINITIES: ASPECTS OF CARE AND HOW THE MEDICAL DISCOURSE AFFECTS THE LIVES OF MEN WITH PHYSICAL DISABILITIES
Authors: T. Huhtaniemi
Journal: Annals of the Rheumatic Diseases (2013)

<b>Abstract: Masculinities: Aspects of care and how the medical discourse affects the lives of men with physical disabilities</b> For me disability is not a physical state but a socially constructed phenomenon. In my Master's thesis the purpose is to outline disability as a gendered phenomenon by focusing on intersection between masculinity and disability. I am interested in identity positions that are possible for disabled men in the context of dominating discourses and what those discourses are like. My material consists of biographical interviews I have done individually with disabled men. The theoretical starting point of my research is the social model of disability that is shaped by Michael Oliver. My purpose is to apply social model of disability to foucauldian point of view. In this way disability can be viewed as a social and discursive distinction that marginalizes disabled people in society by making distinction between "healthy" and "sick" individuals. From the biographical interviews gathered I am searching discourses that are telling, directly or indirectly, about the culture, and the social and institutional practices, that interfere with disability and masculinity. My thesis is made as a part of research project organized by Kynnys ry that is a human rights organization for disabled people in Finland. The thesis isn't completely finished but in my presentation I will introduce you to the results that I have gathered so far. <h3>Disclosure of Interest</h3> None Declared
SPECT Imaging in a Patient With Monostotic Rib Fibrous Dysplasia
Authors: CARLOS E. JIMÉNEZ, ALBERT J. MORENO, ELMER J. PACHECO, ALAN L. CARPENTER
Journal: Clinical Nuclear Medicine (1996)

A 24-year-old man was noted to have a right pleural based mass on his chest radiographs. A Tc-99m HDP bone scan was ordered to evaluate the extent of the disease and to select appropriate sites of biopsy. Delayed planar and SPECT images demonstrated an area of increased uptake involving the right seventh rib lateral area. The differential diagnosis included sarcoma, lymphoma, enchondroma, fibrous dysplasia, bone cyst, or an infectious process. The patient had a biopsy-proven fibrous dysplastic lesion. Fibrous dysplasia is a benign bony neoplasm in which the osteoblasts fail to differentiate normally. Although any bone may be involved, it frequently occurs in only one bone (monostotic). Typical sites of involvement include the skull, femur, tibia, and humerus.
Abstract 3378: Metformin protects head and neck cancer stem cells against DNA damage induced apoptosis
Authors: Selena Z. Kuo, Thomas K. Honda, Eric L. Abhold, Jessica Wang-Rodriguez, Xabier Altuna, Weg M. Ongkeko
Journal: Cancer Research (2012)

Abstract The cancer stem cell hypothesis posits that within a tumor exists a distinct subpopulation of cells responsible for tumor initiation, progression, and maintenance. These cancer stem cells (CSCs) tend to be resistant to conventional chemotherapy and, like normal stem cells, possess the ability to self-renew and differentiate, thereby effecting tumor recurrence. Metformin, the most widely prescribed drug for the treatment of diabetes, has received attention in recent years as a potential anticancer agent capable of targeting cancer stem cells through such means as inhibiting cell proliferation and abrogating chemo-resistance. In the current study, we sought to determine the effects of Metformin on a putative head and neck squamous cell carcinoma (HNSCC) cancer stem cell culture. In contrast to the findings of previous studies, our data suggests that Metformin promotes properties of a cancer stem cell phenotype in HNSCC in vitro. Treatment with Metformin resulted in a dose-dependent induction of the stem cell genes CD44, BMI-1, Oct-4, and Nanog, as measured by qPCR. These results were supported by immunofluorescence data. Metformin treatment promoted self-renewal capacity of HNSCC stem cells, as demonstrated by the increase in size and number of tumorspheres formed in non-adherent and non-differentiating conditions. At various doses, treatment with Metformin alone had no effect on cell proliferation, as measured by MTS assay. Furthermore, when administered in combination with cisplatin, Metformin significantly protected against cisplatin-induced cell death, as demonstrated by MTS and TUNEL assays. Immunoblot experiments demonstrating a decrease in Akt phosphorylation upon treatment with Metformin suggests Metformin-mediated cytoprotection is independent of the Akt pathway. Other possible mechanisms are currently under investigation, including Metformin's ability to regulate autophagy. Although further in vivo studies are necessary, taken together, our findings suggest that Metformin may not be an effective therapeutic option for patients with HNSCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3378. doi:1538-7445.AM2012-3378
INITIAL BIODISTRIBUTION STUDIES OF A RADIOIODINATED GASTRIN RELEASING PEPTIDE (GRP) ANTAGONIST: A POTENTIAL ONCOLOGICAL DETECTION AGENT
Authors: A I Skaro, P L Zabel, T J McDonald, L N Alcorn, D H Coy
Journal: Clinical Nuclear Medicine (1998)

Departments of Nuclear Medicine* and Medicine+, University Campus, London Health Sciences Centre, London, Ontario, Canada and Department of Medicine**, Peptide Research Laboratories, Tulane University Medical Center, New Orleans, Louisiana, USA.
First data on the Evolution duodenal stent for palliation of malignant gastric outlet obstruction (DUOLUTION study): a prospective multicenter study
Authors: M. van den Berg, S. Haijtink, P. Fockens, F. Vleggaar, M. Dijkgraaf, P. Siersema, J. van Hooft
Journal: Endoscopy (2013)

Enteral stent placement has emerged as a safe and effective palliative treatment option for patients with malignant gastric outlet obstruction (GOO). In an attempt to further optimize this treatment new enteral stents have been designed. This study is the first to describe the results regarding technical success, clinical success, complication rate, and stent dysfunction of the Evolution duodenal stent (Cook Medical, Limerick, Ireland).A total of 46 patients with symptomatic malignant GOO were included in this prospective multicenter cohort study. All patients who successfully received an Evolution duodenal stent were followed until death.The technical and clinical success rates were 89 % (95 % confidence interval [CI] 77 % - 95 %) and 72 % (95 %CI 58 % - 83 %), respectively. The GOO Scoring System score, the Global Health Score, and the EuroQol visual analog scale improved significantly (GOOSS and Global Health Score P < 0.0001; EuroQol P = 0.005) when scores before stenting were compared with scores after stent placement. Median survival was 87 days, and stent patency was observed in 67 % for up to 395 days, accounting for death unrelated to the stent as a competing risk. Stent dysfunction occurred in 14 patients (30 %) (stent ingrowth n = 9; stent migration n = 2; extrinsic compression on the stent n = 2; food impaction n = 1).These first data on the new Evolution duodenal stent show that it is safe and effective for the palliative treatment of symptomatic malignant GOO.
Case 15-1990
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Jerry S. Trier, Susan M. Donnelly
Journal: New England Journal of Medicine (1990)

Presentation of CaseA 78-year-old woman was admitted to the hospital because of diarrhea of eight years' duration.The patient was in excellent health until eight years earlier, when she experienced the onset of crampy abdominal pain and loose stools, with the occasional passage of mucus; she passed stools approximately five or six times daily, sometimes at night; she observed that the intake of food, even one grape, provoked abdominal distention, cramps, and diarrhea; her stools were foul-smelling but not greasy. Six years before admission the stools became watery, with the daily passage of 6 to 10 stools. Four months . . .