tbuckley/cabot-search huggingface dataset:
Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy
Authors: Jiahuan Chen, Anutosh Ganguly, Ashley D. Mucsi, Junchen Meng, Jiacong Yan, Pascal Detampel, Fay Munro, Zongde Zhang, Mei Wu, Aswin Hari, Melanie D. Stenner, Wencheng Zheng, Paul Kubes, Tie Xia, Matthias W. Amrein, Hai Qi, Yan Shi
Journal: The Journal of Experimental Medicine (2017)

Dendritic cells are targeted by regulatory T (T reg) cells, in a manner that operates as an indirect mode of T cell suppression. In this study, using a combination of single-cell force spectroscopy and structured illumination microscopy, we analyze individual T reg cell–DC interaction events and show that T reg cells exhibit strong intrinsic adhesiveness to DCs. This increased DC adhesion reduces the ability of contacted DCs to engage other antigen-specific cells. We show that this unusually strong LFA-1–dependent adhesiveness of T reg cells is caused in part by their low calpain activities, which normally release integrin–cytoskeleton linkage, and thereby reduce adhesion. Super resolution imaging reveals that such T reg cell adhesion causes sequestration of Fascin-1, an actin-bundling protein essential for immunological synapse formation, and skews Fascin-1–dependent actin polarization in DCs toward the T reg cell adhesion zone. Although it is reversible upon T reg cell disengagement, this sequestration of essential cytoskeletal components causes a lethargic state of DCs, leading to reduced T cell priming. Our results reveal a dynamic cytoskeletal component underlying T reg cell–mediated DC suppression in a contact-dependent manner.
Investigating Efficacy, Safety, and Biomarkers in a Phase 2 Trial of Pomalidomide + Low-Dose Dexamethasone (POM + LoDEX) Following Second-Line Lenalidomide-Based Therapy (Tx) in Relapsed or Refractory Multiple Myeloma (RRMM)
Authors: David S Siegel, Gary Schiller, Kevin Song, Richy Agajanian, Keith Stockerl-Goldstein, Hakan Kaya, Michael Sebag, Frederic J Reu, Jorge Mouro, Michael Sturniolo, Shankar Srinivasan, Anjan Thakurta, Yasir Nagarwala, Nizar J Bahlis
Journal: Blood (2015)
A survey of knowledge about hepatitis B among new military recruits in China
Authors: Yuan-Yuan Li, Wei-Wei Chen, Lei Wei, Yang-Xin Xie, Li-Feng Wang, Jun-Liang Fu, Fu-Sheng Wang
Journal: Military Medical Research (2017)

Hepatitis B is a disease that affects the liver and is caused by the hepatitis B virus (HBV). Hepatitis B is a serious public health problem in China. The objective of this study was to assess knowledge of and behaviours towards the transmission and prevention of hepatitis B of new military recruits in China. A cross-sectional study was conducted among 800 new military recruits. A self-administered, structured questionnaire was used to collect information, and 727 questionnaires were returned completed. Analysis was performed using SPSS 18.0, and P < 0.05 was considered statistically significant. Of the respondents, 665 (91.5%) were male and 62 (8.5%) were female. The mean age was 18.9 ± 1.7 years. A total of 608 respondents (83.6%) demonstrated poor knowledge and 119 (16.4%) adequate knowledge about HBV. Older age, female and higher education level were statistically associated with a higher mean knowledge score. Multivariate logistic regression showed that age (OR = 3.040, 95%CI 1.724–5.359, P < 0.001) and gender (OR = 1.791, 95%CI 1.325–2.421, P < 0.001) were significantly associated with appropriate behavioural practices towards prevention of HBV. Against a backdrop of high HBV prevalence in China, new military recruits had poor knowledge of HBV. New recruits need better education about HBV to assist in reducing and preventing HBV infection.
MiR-29b Exerts Anti-Multiple Myeloma Activity by Targeting Key Oncogenic Pathways and Modulating DNA Methylation Profile.
Authors: Nicola Amodio, Maria Teresa Di Martino, Umberto Foresta, Marco Rossi, Marzia Leotta, Emanuela Leone, Marta Lionetti, Annamaria Gullà, Patrizia D'Aquila, Dina Bellizzi, Giuseppe Passarino, Fernanda Fabiani, Mariateresa Fulciniti, Manlio Ferrarini, Fortunato Morabito, Antonino Neri, Nikhil C. Munshi, Kenneth C. Anderson, Pierosandro Tagliaferri, Pierfrancesco Tassone
Journal: Blood (2012)
Gene Expressional Profile of Neonatal Neutrophils in Response to Bacterial Lipopolysaccharide (LPS) and Possible Mechanism of Transcription Factor NR4A2 on the Immune Signal Cascade
Authors: Kathy Yuen Yee Chan, Ka Ian Tam, Kam Tong Leung, Tak Yeung Leung, Karen Li, Chi Kong Li, Pak Cheung Ng
Journal: Blood (2015)
Long Term Survival and Relapse Rate After Transplantation of Highly T and B Cell Depleted Stem Cells From Alternative Donors in Pediatric Patients with Acute Lymphatic Leukemia.
Authors: Peter J. Lang, Ingo Mueller, Heiko-Manuel Teltschik, Michael Schumm, Matthias Pfeiffer, Tobias Feuchtinger, Johann Greil, Peter Bader, Thomas Klingebiel, Rupert Handgretinger
Journal: Blood (2009)
Autologous Stem Cell Transplantation Provides Additional Cytoreduction Following Induction Therapy in Multiple Myeloma.
Authors: Shaji Kumar, Martha Lacy, Angela Dispenzieri, Suzanne Hayman, S. Vincent Rajkumar, Steven Zeldenrust, John A. Lust, Philip R. Greipp, Robert Kyle, Morie Gertz
Journal: Blood (2006)
Local inflammation exacerbates cutaneous manifestations in a murine autoimmune pemphigus model
Authors: Sachiko Ono, Gyohei Egawa, Akihiko Kitoh, Teruki Dainichi, Atsushi Otsuka, Saeko Nakajima, Tetsuya Honda, Kenji Kabashima
Journal: Journal of Allergy and Clinical Immunology (2017)
Pediatric Migraine Headache — Still Searching for Effective Treatments
Authors: Jeffrey L Jackson
Journal: New England Journal of Medicine (2017)

Migraine headaches are common in children, adolescents, and adults. In children, migraines have a considerable effect on development, often leading to missed school days, educational delays, and decreased socialization.1 In adults, migraine headaches result in a considerable number of days lost from work. Although there have been hundreds of randomized clinical trials evaluating prophylactic treatment of migraine headache in adults, there have been few controlled studies involving children. In adults, tricyclic antidepressants have shown the greatest benefit in reducing the incidence of migraine headache, but the reduction is modest (a relative difference of approximately 30% as compared with placebo), leaving . . .
c-kit D816V Provides a Strong Signal for Myelomastocytic Differentiation and Cluster Formation in Murine Ba/F3 Cells.
Authors: Matthias Mayerhofer, Karl J. Aichberger, Stefan Florian, Maria-Theresa Krauth, Martin Bilban, Harald Esterbauer, Oswald Wagner, Reinhard Kodym, Karl Sotlar, Jack B. Longley, Hans-Peter Horny, Christian Sillaber, Peter Valent
Journal: Blood (2004)
RAD (Lenalidomide, Adriamycin and Dexamethasone) Is a Novel and Very Effective Induction Regimen in Newly Diagnosed Multiple Myeloma Preceding a Risk-Adjusted Transplant Strategy,
Authors: Stefan Knop, Christian Langer, Monika Engelhardt, Lars O Muegge, Christoph Röllig, Albrecht Reichle, Martin Gramatzki, Wolf Rösler, Hannes Wandt, Bernd Hertenstein, Susanne Höppner, Helmut Ostermann, Isrid Sturm, Tobias Dechow, Mark Ringhoffer, Marianne Sauerwein, Hermann Einsele, Ralf Bargou
Journal: Blood (2011)
Does inflammation predict radiographic progression in hand osteoarthritis?
Authors: Hui Li, Hua Liu
Journal: Annals of the Rheumatic Diseases (2017)

Dear Editor,

We read with deep interest the article by Mathiessen et al 1 aimed to determine whether ultrasound predicts radiographic hand osteoarthritis (OA) progression after 5 years. This prospective study suggested that ultrasound-detected grey-scale synovitis and power Doppler signals were significantly associated with radiographic progression after 5 years. We really appreciate the work conducted by the authors and the findings support the use of ultrasound as a tool to detect patients with hand OA who are likely to progress. However, there are some worthwhile issues that need exploration.

We need to be very careful when assessing the risk factors …
Intrathymic and Extrathymic Notch-Dependent T Lineage Checkpoints during Normal Development and after Bone Marrow Transplantation.
Authors: Ivan Maillard, Arivazhagan Sambandan, Valerie P. Zediak, Benjamin Schwarz, Lanwei Xu, Jon C. Aster, Warren S. Pear, Avinash Bhandoola
Journal: Blood (2004)
Management of Anticoagulation in Patients Who Requiere Colonoscopy or Gastroscopy: Safety and Efficacy of Sodic Bemiparin (Hibor®.
Authors: Maria Amparo Santamaria, Jose Mateo, Nuria Pujol, Juan C. Souto, Mireia Constans, Rosa Ortin, Dolores Llobet, Jordi Fontcuberta
Journal: Blood (2004)
Inhibition of p53-MDM2 Interaction by Small-Molecule Antagonist of MDM2 Effectively Induces Apoptosis in Leukemias.
Authors: Kensuke Kojima, Marina Konopleva, Masato Shikami, Maria Cabreira-Hansen, C. Ellen Jackson, Elizabeth J. Shpall, Steven M. Kornblau, Lubo T. Vassilev, Michael Andreeff
Journal: Blood (2004)
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway
Authors: Shi-Cong Tao, Ting Yuan, Bi-Yu Rui, Zhen-Zhong Zhu, Shang-Chun Guo, Chang-Qing Zhang
Journal: Theranostics (2017)

An excess of glucocorticoids (GCs) is reported to be one of the most common causes of osteonecrosis of the femoral head (ONFH). In addition, GCs can induce bone cell apoptosis through modulating endoplasmic reticulum (ER) stress. Among the three main signal pathways in ER stress, the PERK (protein kinase RNA-like ER kinase)/CHOP (CCAAT-enhancer-binding protein homologous protein) pathway has been considered to be closely associated with apoptosis. Platelet-rich plasma (PRP) has been referred to as a concentration of growth factors and the exosomes derived from PRP (PRP-Exos) have a similar effect to their parent material. The enriched growth factors can be encapsulated into PRP-Exos and activate Akt and Erk pathways to promote angiogenesis. Activation of the Akt pathway may promote the expression of anti-apoptotic proteins like Bcl-2, while CHOP can inhibit B-cell lymphoma 2 (Bcl-2) expression to increase the level of cleaved caspase-3 and lead to cell death. Consequently, we hypothesized that PRP-Exos prevent apoptosis induced by glucocorticoid-associated ER stress in rat ONFH via the Akt/Bad/Bcl-2 signal pathway. To verify this hypothesis, a dexamethasone (DEX)-treated in vitro cell model and methylprednisolone (MPS)-treated in vivo rat model were adopted. Characterization of PRP-Exos, and effects of PRP-Exos on proliferation, apoptosis, angiogenesis, and osteogenesis of cells treated with GCs in vitro and in vivo were examined. Furthermore, the mechanism by which PRP-Exos rescue the GC-induced apoptosis through the Akt/Bad/Bcl-2 pathway was also investigated. The results indicate that PRP-Exos have the capability to prevent GC-induced apoptosis in a rat model of ONFH by promoting Bcl-2 expression via the Akt/Bad/Bcl-2 signal pathway under ER stress.
Abstract 13374: Efficacy and Safety of K-877, a Potent and Selective PPAR-α Modulator (SPPARMα), in Combination With Statins in Japanese Patients With Dyslipidemia
Authors: Hidenori Arai, Shun Ishibashi, Shizuya Yamashita, Eiichi Araki, Koutaro Yokote, Hideki Suganami, Tatsuhiko Kodama
Journal: Circulation (2015)

Background: Residual cardiovascular risk remains despite intensive statin treatment. K-877, a Selective PPAR-α Modulator (SPPARMα), has shown significant reductions in atherogenic lipids with fewer adverse effects than existing PPARα agonists. We hypothesized that K-877 in combination with statins may provide further benefit and risk reduction than statins alone in patients with dyslipidemia. Methods: This is a multi-center double-blind parallel-group study. A total of 423 patients with fasting high TG (≥200 mg/dL), treated with any statins (stable dosage at least 4 weeks prior to the first screening visit) were randomized to the following 24-weeks treatment groups; placebo (n=108), twice-daily K-877 0.2 mg/day (n=150) and 0.2/0.4 mg/day [patients took 0.2 mg/day, those with TG &gt;150 mg/dL at week 8 were uptitrated to 0.4 mg/day from week 12] (n=165 [n=58]). The primary endpoint was the percentage change of TG from baseline, and rates of adverse drug reactions (ADRs) and adverse events (AEs) were assessed. Results: Fasting TG reduction was as follows; placebo: -0.8%, K-877 0.2 mg: -46.8% and K-877 0.2/0.4 mg: -50.8%. K-877 groups had significant reductions compared with placebo (P&lt;0.01). By dose titration at week 12, more patients achieved the target (fasting TG≤150 mg/dL) at week 24 (36.2% in 0.4 mg group and 29.7% in 0.2 mg group). The incidence of AEs/ADRs in K-877 groups was similar to placebo [placebo, K-877 0.2 and 0.2/0.4 mg: 57.4%/15.7%, 56.0%/19.3% and 63.6%/19.4%, respectively]. The study discontinuation rate was also similar across all dosing groups. K-877 reduced liver enzymes compared to placebo [ALT; placebo, K-877 0.2 and 0.2/0.4 mg: -0.9, -12.8 and -8.0 IU/L, respectively] and [γ-GT; -1.8, -42.6 and -40.4 IU/L, respectively]. Severe liver failure, severe renal failure or the rhabdomyolysis were not observed. Frequencies of AEs, such as CK increase and musculoskeletal and connective tissue disorders were comparable to those of placebo. Conclusions: K-877 significantly reduced TG concentrations in dyslipidemic patients on stable statin treatment, was well tolerated, and associated with reductions in liver enzymes. Thus K-877 has a favorable profile of efficacy and safety and may be useful to reduce residual risk in dyslipidemic patients.
The Administration of Bortezomib, Dexamethasone and Thalidomide (VTD) after ASCT in Myeloma Patients Who Do Not Receive Bisphosphonates Normalizes sRANKL, Dickkopf-1 and Improves Abnormal Osteoclast Function and Impaired Angiogenesis.
Authors: Evangelos Terpos, Efstathios Kastritis, Dimitrios Christoulas, Magdalini Migkou, Maria Gavriatopoulou, Meletios A. Dimopoulos
Journal: Blood (2008)
Dosing of Post-Thaw Colony Forming Units (CFU) and CD34 Cells Predict Engraftment and Survival in Recipients of Banked Unrelated Donor Umbilical Cord Blood (UCB) for Allogeneic Transplantation.
Authors: Joanne Kurtzberg, Adam Mendizabal, Shelly Carter, June Allison, Sophie Avrutsky, Connie Stephens, Barbara Waters-Pick
Journal: Blood (2006)
In Vivo Analysis of the Role of C/EBPα in Acute Promyelocytic Leukemia Genesis.
Authors: Barbara A.A. Santana-Lemos, Florence Guibal, Maria-Carolina Pintao, Priscila S. Scheucher, Rodrigo S. Abreu-Lima, Hamilton L.G. Teixeira, Pier Paolo Pandolfi, Daniel G. Tenen, Eduardo M. Rego
Journal: Blood (2006)
RETRACTED: The Pseudogene DUXAP8 Promotes Non-small-cell Lung Cancer Cell Proliferation and Invasion by Epigenetically Silencing EGR1 and RHOB
Authors: Ming Sun, Feng-qi Nie, Chongshuang Zang, Yunfei Wang, Jiakai Hou, Chenchen Wei, Wei Li, Xiang He, Kai-hua Lu
Journal: Molecular Therapy (2017)

Recently, the non-protein-coding functional elements in the human genome have been identified as key regulators in postgenomic biology, and a large number of pseudogenes as well as long non-coding RNAs (lncRNAs) have been found to be transcribed in multiple human cancers. However, only a small proportion of these pseudogenes has been functionally characterized. In this study, we screened for pseudogenes associated with human non-small-cell lung cancer (NSCLC) by comparative analysis of several independent datasets from the GEO. We identified a transcribed pseudogene named DUXAP8 that is upregulated in tumor tissues. Patients with higher DUXAP8 expression exhibited shorter survival, suggesting DUXAP8 as a new candidate prognostic marker for NSCLC patients. Knockdown of DUXAP8 impairs cell growth, migration, and invasion, and induces apoptosis both in vitro and in vivo. Mechanistically, DUXAP8 represses the tumor suppressors EGR1 and RHOB by recruiting histone demethylase LSD1 and histone methyltransferase EZH2, thereby promoting cell proliferation, migration, and invasion. These findings indicate that the pseudogene DUXAP8 may act as an oncogene in NSCLC by silencing EGR1 and RHOB transcription by binding with EZH2 and LSD1, which may offer a novel therapeutic target for this disease. Recently, the non-protein-coding functional elements in the human genome have been identified as key regulators in postgenomic biology, and a large number of pseudogenes as well as long non-coding RNAs (lncRNAs) have been found to be transcribed in multiple human cancers. However, only a small proportion of these pseudogenes has been functionally characterized. In this study, we screened for pseudogenes associated with human non-small-cell lung cancer (NSCLC) by comparative analysis of several independent datasets from the GEO. We identified a transcribed pseudogene named DUXAP8 that is upregulated in tumor tissues. Patients with higher DUXAP8 expression exhibited shorter survival, suggesting DUXAP8 as a new candidate prognostic marker for NSCLC patients. Knockdown of DUXAP8 impairs cell growth, migration, and invasion, and induces apoptosis both in vitro and in vivo. Mechanistically, DUXAP8 represses the tumor suppressors EGR1 and RHOB by recruiting histone demethylase LSD1 and histone methyltransferase EZH2, thereby promoting cell proliferation, migration, and invasion. These findings indicate that the pseudogene DUXAP8 may act as an oncogene in NSCLC by silencing EGR1 and RHOB transcription by binding with EZH2 and LSD1, which may offer a novel therapeutic target for this disease.
Antigen Presenting Cell-Mediated Ex Vivo Expansion of Human Umbilical Cord Blood Cells Yields Log-Scale Expansion of Natural Killer Cells with Anti-Myeloma Activity
Authors: Nina Shah, Dongxia Xing, Dean A. Lee, Laurence J.N. Cooper, William Decker, Sufang Li, Simon Robinson, Hong Yang, Simrit Parmar, Shawndeep Tung, Michael Wang, Richard Champlin, Catherine M Bollard, Elizabeth J. Shpall
Journal: Blood (2010)
Maternal Haplotype at Time of Banking Is an Effective Strategy to Guarantee the Identification and Traceability of Cord Blood Units.
Authors: Paola Bergamaschi, Cesare Perotti, Gianluca Viarengo, Claudia Del Fante, Cristina Parisi, Andrea Marchesi, Laura Bellotti, Valentina Galiazzo, Annamaria Pasi, Miryam Martinetti, Laura Salvaneschi
Journal: Blood (2006)
Paediatric Erdheim–Chester disease with aggressive skin manifestations
Authors: H.‐H. Su, W. Wu, Y. Guo, H.‐D. Chen, S.‐J. Shan
Journal: British Journal of Dermatology (2017)

Erdheim-Chester disease (ECD), a type of systemic non-Langerhans cell histiocytosis, is uncommon and characterized by the accumulation of CD68+ CD1a- foamy histiocytes. It is extremely rare in children. The skin lesions of paediatric ECD have not been systemically described before. We report a case of ECD in a 3·5-year-old Chinese boy. The patient presented with generalized skin and bone involvement of 3 years' duration. Marked generalized annular maculopapular lesions with central atrophy were seen. These differed from previously reported adult xanthoma-like papules or periorbital xanthelasma-like lesions. Computed tomography revealed diffuse pulmonary fibrosis and generalized skeletal involvement, including osteolysis and osteosclerosis. The presence of CD68+ CD1a- histiocytes allowed the diagnosis of ECD. According to our review of the literature, this is the paediatric case of ECD with the youngest age of onset. The generalized skin involvement made our case unique in comparison with those previously reported.
Reply to Christian Daniel Fankhauser, Lorelei A. Mucci, and Travis A. Gerke's Letter to the Editor re: Won Sik Ham, Heather J. Chalfin, Zhaoyong Feng, et al. New Prostate Cancer Grading System Predicts Long-term Survival Following Surgery for Gleason Score 8–10 Prostate Cancer. Eur Urol 2017;71:907–12
Authors: Jonathan I. Epstein, Bruce Trock, Misop Han
Journal: European Urology (2017)
Direct Administration of Nerve-Specific Contrast to Improve Nerve Sparing Radical Prostatectomy
Authors: Connor W. Barth, Summer L. Gibbs
Journal: Theranostics (2017)

Nerve damage remains a major morbidity following nerve sparing radical prostatectomy, significantly affecting quality of life post-surgery. Nerve-specific fluorescence guided surgery offers a potential solution by enhancing nerve visualization intraoperatively. However, the prostate is highly innervated and only the cavernous nerve structures require preservation to maintain continence and potency. Systemic administration of a nerve-specific fluorophore would lower nerve signal to background ratio (SBR) in vital nerve structures, making them difficult to distinguish from all nervous tissue in the pelvic region. A direct administration methodology to enable selective nerve highlighting for enhanced nerve SBR in a specific nerve structure has been developed herein. The direct administration methodology demonstrated equivalent nerve-specific contrast to systemic administration at optimal exposure times. However, the direct administration methodology provided a brighter fluorescent nerve signal, facilitating nerve-specific fluorescence imaging at video rate, which was not possible following systemic administration. Additionally, the direct administration methodology required a significantly lower fluorophore dose than systemic administration, that when scaled to a human dose falls within the microdosing range. Furthermore, a dual fluorophore tissue staining method was developed that alleviates fluorescence background signal from adipose tissue accumulation using a spectrally distinct adipose tissue specific fluorophore. These results validate the use of the direct administration methodology for specific nerve visualization with fluorescence image-guided surgery, which would improve vital nerve structure identification and visualization during nerve sparing radical prostatectomy.
Colorectal cancer cells use the negative feedback regulators of WNT signalling to activate epithelial–mesenchymal transition pathways
Authors: Eugene Tulchinsky
Journal: Gut (2017)

Epithelial–mesenchymal transition (EMT) is a reversible embryonic genetic programme pathologically activated in cancer. The EMT phenomenon has been considered in the context of distant metastases in different carcinoma types including colorectal cancer (CRC). The hallmark of EMT is dissolution of epithelial intercellular junctions and global reorganisation of the cytoskeleton leading to the loss of epithelial features and gain of mesenchymal morphology. EMT programmes are controlled by several groups of embryonic transcription factors (EMT-TFs), of which TWIST1, SNAIL1, ZEB1 and ZEB2 expression correlated with poor prognosis in patients with CRC.1 The role of EMT in cancer is not limited to enhanced invasion; a growing body of evidence implicates EMT-TFs in control of cell division, drug resistance, escape from senescence and oncogenic transformation. Activation of EMT pathways by driver oncogenic mutations was proposed to couple neoplastic transformation with the formation of quiescent circulating tumour cells (CTCs), dormant metastases and eventually early dissemination.2 In support of this theory, acquisition of mesenchymal phenotype was documented in CTCs isolated from the peripheral blood of patients with CRC.3

Accumulating evidence indicates strong association between EMT and WNT/β-catenin signalling, a pathway most commonly activated in CRC. Mutational activation of this pathway results in nuclear translocation of β-catenin in model systems. However, in central parts of colorectal tumours, cells maintain normal membranous localisation of β-catenin. Its nuclear localisation is often observed in tumour areas surrounded by the stroma due to the influence of microenvironmental factors.4 Cells at the tumour-stroma interphase are often also EMT-TFs-positive suggesting that a crosstalk between WNT and …
Double-Stranded RNA Acts as a Strong Danger Signal in Human Myeloid Leukemia Cells Leading to Increased Immunogenicity.
Authors: Zwi N. Berneman, Evelien L.J.M. Smits, Peter Ponsaerts, Nathalie Cools, Ann L.R. Van de Velde, Alain P. Gadisseur, Wilfried A. Schroyens, Viggo F.I. Van Tendeloo
Journal: Blood (2006)