tbuckley/cabot-search huggingface dataset:
SAT0418 IGA Anti-Phosphatidylserin/Prothrombin Antibodies Present a Thrombotic Risk in Patients with Systemic Autoimmune Diseases: Table 1
Authors: P. Žigon, A. Ambrožič, M. Tomšič, S.S. Šemrl, S. Čučnik
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Studies on antiphospholipid antibodies (aPL) have mainly focused on the IgG and IgM isotypes, with only a few on the pathogenic significance of IgA aPL. Positive IgA anticardiolipin (aCL) and IgA anti-β<sub>2</sub>glycoprotein I (anti-β<sub>2</sub>GPI) were reported to be predominantly associated with other aPL, making it difficult to understand the role of IgA alone [1]. Recently, antibodies against phosphatidylserin/prothrombin (aPS/PT) IgG and IgM have been indicated as a potential marker for antiphospholipid syndrome (APS) [2, 3]. Our previous study reported that IgG and IgM aPS/PT showed highest association with lupus anticoagulant (LA) activity of all tested aPL [3], while no studies to date have investigated possible clinical benefits of IgA aPS/PT. <h3>Objectives</h3> To determine the prevalence of IgA aPS/PT in patients with systemic autoimmune diseases and evaluate their association to thrombosis and obstetric complications. <h3>Methods</h3> We examined 254 patients with systemic autoimmune diseases: 91 APS, 40 APS secondary to systemic lupus erythematosus (SLE), 47 SLE, 57 rheumatoid arthritis (RA) and 19 Sjögren9s syndrome (SS) patients for LA, aCL, anti-β<sub>2</sub>GPI and aPS/PT (for IgG, IgM, IgA isotypes) [4]. 55 subjects experienced arterial thrombosis (AT), 60 venous thrombosis (VT) and 54 obstetric complications (OC). <h3>Results</h3> An overall prevalence of 63/254 (25%) was found for IgA aPS/PT in our cohort of patients. IgA aPS/PT were statistically significantly associated to both AT and VT (p=0.026 and p=0.002, respectively), however no association was found to OC (p=0.534). 19/63 (30%) patients were solely positive for IgA aPS/PT and negative for IgG or IgM aPS/PT. Five of these patients (3 SLE, 1 RA and 1 SS) were concomitantly negative also for LA, aCL and anti-β<sub>2</sub>GPI. One of the solely positive IgA aPS/PT patients experienced AT, while the other four showed no clinical manifestations significant for APS. IgA aPS/PT showed significant association with LA activity (p&lt;0.001; OR 4.7), comparable to IgG anti-β<sub>2</sub>GPI (OR 5.1) and higher than IgG/IgM aCL (OR&lt;3.4) or IgM/IgA anti-β<sub>2</sub>GPI (OR&lt;2.9). <h3>Conclusions</h3> IgA aPS/PT presented an independent risk factor for thrombosis, and highly correlated to LA activity. Larger studies are needed to confirm whether IgA aPS/PT testing could contribute to the assessment of thrombotic risk, especially in “seronegative” APS patients. <h3>References</h3> Bertolaccini ML et. al., Autoimmunity reviews. 2014;13(9):917-30. Sciascia S, et al. Thrombosis and haemostasis. 2013;111(2). Zigon P, et al. Clinical and Developmental Immunology. 2013;2013:8. Zigon P, et al. Clin Chem Lab Med. 2011, 49:1011-1018 <h3>Disclosure of Interest</h3> None declared
Perspectives on the Role of Protein Kinase C in Stimulus-Response Coupling&lt;xref ref-type="fn" rid="FN4"&gt;4&lt;/xref&gt;
Authors: Y Nishizuka
Journal: JNCI Journal of the National Cancer Institute (1986)

Perspectives on the Role of Protein Kinase C in Stimulus-Response Coupling 3,4Protein kinase C has now attracted great attention for the studies on the activation of cellular functions and proliferation, and our knowledge of the possible role of this enzyme in cell surface signal transduction is expanding rapidly.It is also becoming clear that many of the pleiotropic actions, if not all, of tumor promoters are probably mediated through the action of this enzyme.Under physiologic conditions protein kinase C is activated by association with membrane phospholipids in the presence of diacylglycerol.The diacylglycerol active in this role may arise in the membrane only transiently from the receptor-mediated hydrolysis of inositol phospholipids.The signals that are related to protein kinase C normally differ from those for the group of hormones, neurotransmitters, and many other biologically active substances that produce cAMP.Thus protein kinase C and protein kinase A may transduce distinctly different pieces of information into the cell via their own specific protein phosphorylation.Several aspects of this protein kinase C pathway have been reviewed (1, 2), and this article will describe some overall perspectives on the role of this protein kinase.
SAT0469 Calcinosis Cutis in Poly-Dermatomyositis: Clinical and Therapeutic Study
Authors: M. Fredi, F. Bartoli, I. Cavazzana, N. Carabellese, A. Ceribelli, A. Tincani, M. Satoh, F. Franceschini
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Subcutaneous or soft-tissue calcification is a recognized manifestation of many connective-tissue diseases; however, little is known about the pathogenesis and the treatment of this condition. <h3>Objectives</h3> To identify the possible clinical and laboratory predictors of calcinosis by analyzing clinical and immunologic characteristic in a cohort of patients with a diagnosis of Poly-dermatomyositis (PDM). <h3>Methods</h3> Seventy-four patients with a diagnosis of PDM referred to our Rheumatology and Immunology Unit were studied: 16 had calcinosis (C+) and 58 did not (C-). Clinical and laboratory data were collected from clinical charts. Statistical analysis was performed using the Chi-squared test and Student t test, p&lt;0.05 is considered statistically significant. <h3>Results</h3> The diagnoses in the C+ group were Dermatomyositis (12 patients), Polymyositis (1 patient) and Polymyositis and Systemic Sclerosis (SSc) Overlap syndrome (3 patients). The mean age at onset in the C+ group was 42.9 years (±20.4) and there was a predominance of females (81% vs 78%). Calcinosis occurred on average 43.7 months (SD 71.4 months) after diagnosis of connective-tissue disease. The first lesion was single in 11 cases (69%) and multiple in 5 (31%), with a predominant involvement of pelvic girdle (50%), root of higher limbs (25%), hands (25%), forearms and legs (13%). Pain associated to calcinosis was present in 9 cases (56%), while ulceration or superinfection of calcinosis were detected in 7 patients (44%). Therapies used for calcinosis were: colchicine (56%), diltiazem (44%), IVIg (44%), sodium thiosulfate cream (31%), calcium-channel blockers (19%), warfarin (13%), rituximab (13%), infliximab (13%). A limited improvement was reported: subjective improvement (colchicine,1 case), reduction in pain (IVIg,1) and resolution of rubor overlying calcifications (rituximab,1). Surgical treatment of calcinosis was conducted in 38% of PDM patients. C+ group distinguishing features compared to C- group are shown in the table. Notably 4 out of 5 anti-PM/Scl (80%) as well as 4 out of 8 (50%) anti-MJ/NXP2 antibodies were found in patients with calcinosis. <h3>Conclusions</h3> PDM patients with calcinosis constitute a disease subset characterized by: higher frequency of DM, inflammatory skin involvement as Gottron9s papules, and increased frequency of pulmonary involvement (lower DLCO/VA) Anti-PM/Scl antibodies are more frequent in the C+ group (p&lt;0.007): this reflects the increased frequency of Overlap PM-SSc Syndrome in C+ compared to C- (18.7% vs 9%). Anti-MJ/NXP-2 positivity tend to be more frequent in the C+ group (p=0.06). No drug treatment is effective in reducing the extension of calcinosis, but, in some cases, colchicine, intravenous Ig and rituximab induced a subjective improvement in symptoms related to calcinosis. <h3>Disclosure of Interest</h3> None declared
Fibromuscular hyperplasia of the internal carotid artery.
Authors: A E Wilkinson
Journal: BMJ (1971)

that aspirin has a profound effect on platelet behaviourthe effects of two tablets can be detected for several days4 -yet although aspirin has been shown to prolong the bleeding time its use has never been found to be a major surgical hazard.If volatile anaesthetics carry a theoretical risk of bleeding during surgery, they presumably also pro- vide a theoretical benefit to the patient in preventing post- operative venous thrombosis.
Prevalence and diagnostic reliability of methadone maintenance detoxification fear
Authors: J B Milby, R H Gurwitch, D J Wiebe, W Ling, A T McLellan, G E Woody
Journal: American Journal of Psychiatry (1986)

The authors identified a pathological fear of methadone detoxification in 22%, 25%, and 32% of random samples of patients in three disparate methadone maintenance programs. Patients with a pathological fear of detoxification had higher scores on the Detoxification Fear Survey Schedule, had longer histories of addiction, had been addicted for a larger percent of their life spans, and were older than patients without this fear. A greater proportion of the female patients had this fear, and a greater proportion of the patients with this fear had drug-free urinalyses. The authors recommend the use of the Detoxification Fear Survey Schedule as well as intervention to help rehabilitated opioid addicts initiate and complete detoxification.
The Early Diagnosis of the Acute Abdomen.
Authors: R E GREENFIELD, A K MYRABO
Journal: Annals of Internal Medicine (1973)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effect of Actinomycin D on Tissue Cultures of Normal and Neoplastic Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Jewel Plummer Cobb, Dorothy G. Walker
Journal: JNCI Journal of the National Cancer Institute (1958)

Actinomycin D produced a range of nonspecific cytotoxic changes in human neoplastic and normal primary tissue cultures. Neoplastic primary cultures were generally more sensitive to the action of actinomycin D than normal primary cultures, as judged by their cytological changes. On the other hand, both showed marked reduction in mitosis. Both neoplastic and normal established cell strains showed only mild sensitivity to the same concentrations of actinomycin D that damaged primary cultures. Sensitivity was indicated by an increase in the number of aberrant metaphases. There were relatively fewer aberrant metaphases in treated HeLa cultures as compared with conjunctiva and kidney cultures. A selective response to actinomycin D has been shown to exist among the primary cultures included in this study. In view of these observations further study of the use of primary cultures for evaluating the in vitro effects of a potential chemotherapeutic agent is suggested.
OP0274 Cryoglobulinemic Vasculitis and Primary sjögren's Syndrome are Independent Risk Factors for Lymphoma in a Large Worldwide Population of Patients with Positive Serum Cryoglobulins
Authors: L. Quartuccio, L. Corazza, M. Ramos-Casals, S. Retamozo, G.M. Ragab, G. Ferraccioli, E. Gremese, A. Tzioufas, M. Voulgarelis, D. Vassilopoulos, C. Koutsianas, S. Scarpato, C. Salvarani, L. Guillevin, B. Terrier, P. Cacoub, F. Saccardo, A. Gabrielli, P. Fraticelli, M. Tomsic, A. Tavoni, N. Nishimoto, D. Filippini, P. Scaini, A.L. Zignego, C. Ferri, D. Sansonno, G. Monti, M. Pietrogrande, M. Galli, S. Bombardieri, S. De Vita
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Serum cryoglobulins (SC) may be found in many diseases (1), and the presence of serum cryoglobulins is a known risk factor for lymphoma evolution in some non malignant diseases. <h3>Objectives</h3> The aim of this study was to distiguish the role of cryoglobulinemic vasculitis (CV), classified according to the recent validated criteria (1,2), and primary Sjögren9s syndrome (pSS) as risk factors of lymphoma in patients positive serum cryoglobulins. Importantly, SC, CV and pSS may occur together. <h3>Methods</h3> 950 charts from consecutive patients with positive SC were evaluated. Patients carrying both pSS and HCV infection, as well as incomplete charts, were excluded. <h3>Results</h3> 657 patients with SC were selected, 374 with CV and 283 without CV, according to the published criteria (2,3). PSS, classified according to the American-European Group Criteria was present in 96 patients (44 with CV, 52 without). Lymphoma was reported in 61/657 (9.8%) patients with SC. Among them, CV was present in 44/61 (72,1%; 14 also with pSS), and pSS in 17/61 (27,9%; and 14/17 had CV). Patients with SC with CV showed an higher prevalence of lymphoma than patients with SC without CV (44/374, 11.5% vs.17/283, 6.3%; p=0.025, OR=1.93 [95%IC: 1.08-3.39]. Patients with pSS, SC and CV also showed a higher prevalence of lymphoma than patients with pSS, SC but without CV (14/44, 31.8% vs. 3/52, 7.4%; p=0.001, OR=7.62 [95%CI 2.02-28.74]. CV and pSS were confirmed as independent risk factor for lymphoma by multivariate analysis (OR 2,18 95%CI 1,18-3,83, p=0,012; OR 2,65 95%CI 1,04-6,76, p=0,042, respectively). Infection by the hepatitis C virus (HCV) was detected in 467/561 (83,2%) patients with SC without pSS, and did not statistically predispose to lymphoma when associated with CV in this subset (p=1,0). <h3>Conclusions</h3> Cryoglobulinemic vasculitis and pSS are independent risk factors for lymphoma in patients with evidence of SC. Patients with both the conditions (CV and pSS) have the highest risk. In the follow-up of SC positive patients, a very high attention should be deserved to pSS, in particular when CV is present. <h3>References</h3> De Vita S, et al. Ann Rheum Dis. 2011; 2) Quartuccio L, et al. Rheumatology (Oxford). 2014 <h3>Disclosure of Interest</h3> None declared
Henry Dearborn
Authors: Howard N. Simpson
Journal: New England Journal of Medicine (1955)

TOWARD the end of his life Thomas Jefferson wrote to an old friend, the man who had been his secretary of war for eight years: "Man, like the fruit he eats, has his period of ripeness. Like that, too, if he continues longer hanging to the stem, it is but a useless and unsightly appendage." The friend was Henry Dearborn, for whom Fort Dearborn was named, and whom history has dismissed with a paragraph because, as senior major general, his inactivity and inefficiency contributed measurably to the ineffectiveness of American land forces in "Mr. Madison's War." The words were unintentionally . . .
Studies of Various Tests for Malignant Neoplastic Diseases. V. The Heat “Coagulation” of Plasma
Authors: Nils Eriksen, Lester D. Ellerbrook, Edward C. Meek, Stuart W. Lippincott
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Studies of Various Tests for Malignant Neoplastic Diseases. V. The Heat “Coagulation” of Plasma Get access Nils Eriksen, Nils Eriksen Search for other works by this author on: Oxford Academic PubMed Google Scholar Lester D. Ellerbrook, Lester D. Ellerbrook Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward C. Meek, Edward C. Meek Search for other works by this author on: Oxford Academic PubMed Google Scholar Stuart W. Lippincott Stuart W. Lippincott Clinical Trials Unit, Cancer Control Branch, National Cancer Institute, Bethesda, Md., and Department of Pathology, School of Medicine, University of Washington, Seattle, Wash. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 4, February 1951, Pages 757–771, https://doi.org/10.1093/jnci/11.4.757 Published: 01 February 1951 Article history Received: 26 September 1950 Published: 01 February 1951
Brief Communication: Transplantation of Adenocarcinomas of the Colon in Mice 2
Authors: J. A. Double, C. R. Ball, P. N. Cowen
Journal: JNCI Journal of the National Cancer Institute (1975)

1, 2-Dimethylhydrazine treatment induced multiple colon tumors in 100% of NMRI mice. Many of these tumors were transplanted and yielded five serially transplantable tumor lines. These subcutaneously transplanted neoplasms were all adenocarcinomas varying in degree of differentiation and mucin production. No evidence of dedifferentiation or change in growth rate has been seen in up to six transplant generations. These tumor lines appeared to provide relatively stable, well-differentiated models for colorectal cancer.
PWE-316 Incidence and management of iatrogenic perforations in the welsh bowel screening programme
Authors: F Dewi, H Heard, M Davies, S Dolwani, J Torkington
Journal: Gut (2015)

<h3>Introduction</h3> Iatrogenic perforation is a rare but serious complication of colonoscopy. Reported incidence varies between 0.005% and 0.629%, and is mostly based on diagnostic and therapeutic rather than screening colonoscopies. The British Society of Gastroenterology (BSG) has set a target of no more than one perforation in every 1000 screening colonoscopies. <h3>Method</h3> All cases of iatrogenic perforations within the Bowel Screening Wales programme between January 2009 and December 2014 were identified. As part of a robust Quality Assurance programme, a policy of detailed root cause analysis was introduced in 2011; this was subsequently performed for all cases and outcomes recorded. <h3>Results</h3> 17,699 screening colonoscopies were performed within the specified time period, of which 10,688 proceeded to polypectomy (60.4%). There were 13 perforations (0.073%), of which 11 underwent root cause analysis. Of these, nine cases were following polypectomy, one was following negotiation around a splenic flexure malignant tumour and one was during a difficult colonoscopy in the context of multiple adhesions and diverticular disease. Almost all were managed with emergency surgery (n = 10). There was one fatality as a result of colonoscopy (0.006%). <h3>Conclusion</h3> Our perforation rate falls well below the BSG target and is lower than most of the previously published rates for therapeutic and diagnostic colonoscopies. Management of perforations tends to be less conservative than expected, and this was addressed with individual feedback, education and training. Bowel screening is a safe procedure with a low rate of perforation and a low risk of morbidity and mortality. <h3>Disclosure of interest</h3> None Declared.
Transfusion Hepatitis in Copenhagen 1955-1959
Authors: H DOMELA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-109 Endoscopic papillectomy: feasibility, safety and efficacy data from a single uk centre
Authors: K Kandiah, F Chedgy, A Kumar, R Bhattacharyya, P Goggin, P Bhandari
Journal: Gut (2015)

<h3>Introduction</h3> Endoscopic papillectomy is an alternative to radical surgery (10% mortality risk) in the management of ampullary adenomas. Very few centres in the UK have the expertise or experience of performing this procedure and there is certainly no published literature from the UK. We aim to report outcomes after endoscopic papillectomy in a single tertiary endoscopy unit in the UK. <h3>Method</h3> The prospectively collected data of all patients who underwent endoscopic papillectomy between 2005 and 2015 in Queen Alexandra Hospital, Portsmouth were reviewed. All procedures were carried out by PB (papillectomy) and PG (ERCP) using a standard duodenoscope. The pancreatic and biliary ducts were cannulated. A dilute methylene blue dye was injected into the pancreatic duct prior to papillectomy. Submucosal injection was performed in all cases prior to snare resection of the ampullary neoplasia. 5 Fr pigtail pancreatic stent insertion was attempted in all cases after resection of the neoplasia. <h3>Results</h3> A total of thirty-five patients were referred for papillectomy but only twenty-two patients (13 female, median age 72 years) underwent a total of 24 papillectomies. En-bloc resection was achieved in 17 patients (77%) with lesion sizes ranging from 8–25 mm (Median 16 mm). Pancreatic stent placement was successful in 82% of all papillectomies. Three patients experienced complications (12.5%); 2 bleeding and 1 acute pancreatitis. There was no procedure related deaths and no one required emergency surgery. There were no local recurrences in 77% of patients. Two patients required 2 attempts to achieve complete clearance of their adenomas. Histology of the resected lesions revealed low grade dysplasia (54.6%), high grade dysplasia (27.2%), cancer (9%), gangliocytic paraganglioma (4.6%), and neuroendocrine tumour (4.6%). Of the two patients who were found to have invasive cancer, the first patient went on to have a pancreaticoduodenectomy and subsequently died of post-operative complications and the second patient was palliated. The total curative resection rate was 86%. <h3>Conclusion</h3> This is the largest reported UK series of endoscopic papillectomy. Our data demonstrates that this method is a feasible, safe and efficacious means of treating ampullary neoplasia in expert hands. It obviates the need for pancreaticoduodenectomy with its inherent morbidity and mortality. Complications can be serious and expertise is required to deal with them. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Suzuki K, Kantou U, Murakami Y. Two cases with ampullary cancer who underwent endoscopic excision. Prog Dig Endosc. 1983;23:236–239 De Palma GD. Endoscopic papillectomy: indications, techniques, and results. World J Gastroenterol. 2014;20(6):1537–1543