tbuckley/cabot-search huggingface dataset:
Engagement of Sectors Other than Health in Integrated Health Governance, Policy, and Action
Authors: Evelyne de Leeuw
Journal: Annual Review of Public Health (2017)

Health is created largely outside the health sector. Engagement in health governance, policy, and intervention development and implementation by sectors other than health is therefore important. Recent calls for building and implementing Health in All Policies, and continued arguments for intersectoral action, may strengthen the potential that other sectors have for health. This review clarifies the conceptual foundations for integral health governance, policy, and action, delineates the different sectors and their possible engagement, and provides an overview of a continuum of methods of engagement with other sectors to secure integration. This continuum ranges from institutional (re)design to value-based narratives. Depending on the lens applied, different elements can be identified within the continuum. This review is built on insights from political science, leadership studies, public health, empirical Health in All Policy research, knowledge and evidence nexus approaches, and community perspectives. Successful integration of health governance, policy, and action depends on integration of the elements on the continuum.
Primary Plasma Cell Leukemia: Results of a Retrospective Italian Multicentric Survey.
Authors: Livio Pagano, Caterina Giovanna Valentini, Valerio De Stefano, Adriano Venditti, Giuseppe Visani, Maria Teresa Petrucci, Anna Candoni, Giorgina Specchia, Carlo Visco, Enrico Maria Pogliani, Felicetto Ferrara, Piero Galieni, Alessandro Gozzetti, Giuseppe Avvisati, Giuseppe Leone, Pellegrino Musto, Alessandro Pulsoni
Journal: Blood (2009)
Physiological TCR Modulation after Antigen Specific Triggering of Introduced TCRs under Control of a Retroviral Promotor.
Authors: Marleen M. van Loenen, Renate S. Hagedoorn, Esther H.M. van Egmond, Roel Willemze, J.H.Frederik Falkenburg, Mirjam H.M. Heemskerk
Journal: Blood (2005)
Recurrent Genetic Abnormalities Are Reflected in Phenotype at Diagnosis in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group Protocol AAML0531
Authors: Andrew P. Voigt, Lisa Eidenschink Brodersen, Robert B. Gerbing, Andrew J. Menssen, Betsy A. Hirsch, Susana C. Raimondi, Alan S. Gamis, Todd A. Alonzo, Soheil Meshinchi, Michael R. Loken
Journal: Blood (2015)
Carfilzomib Plus High Dose Melphalan Conditioning Prior to Autologous Hematopoietic Cell Transplantation Followed By Carfilzomib Maintenance in Patients with Relapsed Multiple Myeloma
Authors: Luciano J. Costa, Heather Landau, Saurabh Chhabra, Parameswaran Hari, Donna Salzman, Ayman Saad, Racquel Innis-Shelton, Mehdi Hamadani, Roni Tamari, Kelly N. Godby, Vladimir Petrovic, Lisa Williams, Evelyn Orlando, Pamela M Dixon, Sergio A. Giralt
Journal: Blood (2016)
Functional role and therapeutic targeting of p21-activated kinase 4 in multiple myeloma
Authors: Mariateresa Fulciniti, Joaquin Martinez-Lopez, William Senapedis, Stefania Oliva, Rajya Lakshmi Bandi, Nicola Amodio, Yan Xu, Raphael Szalat, Annamaria Gulla, Mehmet K. Samur, Aldo Roccaro, Maria Linares, Michele Cea, Erkan Baloglu, Christian Argueta, Yosef Landesman, Sharon Shacham, Siyuan Liu, Monica Schenone, Shiaw-Lin Wu, Barry Karger, Rao Prabhala, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2017)
Novel real-time PCR-based patho- and phylotyping of potentially zoonotic avian influenza A subtype H5 viruses at risk of incursion into Europe in 2017
Authors: Mahmoud M Naguib, Annika Graaf, Andrea Fortin, Christine Luttermann, Ulrich Wernery, Nadim Amarin, Hussein A Hussein, Hesham Sultan, Basem Al Adhadh, Mohamed K Hassan, Martin Beer, Isabella Monne, Timm C Harder
Journal: Eurosurveillance (2017)

Since November 2016, Europe witnesses another wave of incursion of highly pathogenic avian influenza (HPAI) A(H5) viruses of the Asian origin goose/Guangdong (gs/GD) lineage. Infections with H5 viruses of clade 2.3.4.4b affect wild bird and poultry populations. H5 viruses of clades 2.2, 2.3.1.2c and 2.3.4.4a were detected previously in Europe in 2006, 2010 and 2014. Clades 2.2.1.2 and 2.3.2.1.c are endemic in Egypt and Western Africa, respectively and have caused human fatalities. Evidence exists of their co-circulation in the Middle East. Subtype H5 viruses of low pathogenicity (LPAI) are endemic in migratory wild bird populations. They potentially mutate into highly pathogenic phenotypes following transmission into poultry holdings. However, to date only the gs/GD H5 lineage had an impact on human health. Rapid and specific diagnosis marks the cornerstone for control and eradication of HPAI virus incursions. We present the development and validation of five real-time RT-PCR assays (RT-qPCR) that allow sequencing-independent pathotype and clade-specific distinction of major gs/GD HPAI H5 virus clades and of Eurasian LPAI viruses currently circulating. Together with an influenza A virus-generic RT-qPCR, the assays significantly speed up time-to-diagnosis and reduce reaction times in a OneHealth approach of curbing the spread of gs/GD HPAI viruses.
Phase II Trial of Ofatumumab (OFA) in Previously Untreated Follicular Non-Hodgkin Lymphoma (NHL): CALGB 50901 (Alliance)
Authors: Cara A. Rosenbaum, Brandelyn Pitcher, Nancy L Bartlett, Sonali M. Smith, Jane Jijun Liu, Eric D. Hsi, Sin-Ho Jung, John P. Leonard, Bruce D. Cheson
Journal: Blood (2015)
Superior antitumor activity of NK012, 7-ethyl-10-hydroxycamptothecin-incorporating micellar nanoparticle, to irinotecan
Authors: Takeshi Onda, Iwao Nakamura, Chieko Seno, Shinichi Matsumoto, Masayuki Kitagawa, Kazuya Okamoto, Kiyohiro Nishikawa, Masanobu Suzuki
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

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Irinotecan hydrochloride (CPT-11) is clinically used to treat various tumors, but low conversion rate to an active metabolite, 7-ethyl-10-hydroxycamptothecin (EHC or SN-38) and low retention of EHC in tumor tissue limit its therapeutic effect. To exploit therapeutic potential of EHC by optimizing its pharmacokinetic properties, we synthesized NK012, EHC-incorporating micellar nanoparticle. EHC binds chemically to poly(ethylene glycol)-poly(glutamic acid) block copolymer, which forms nanosized-micellar particle in aqueous solution. The micellar NK012 gradually releases EHC in enzyme-independent manner at physiological pH. Here, we report antitumor activities and pharmacokinetic profiles of NK012 in tumor-bearing animal models. Against human tumor xenografts in nude mice, intravenous injection of NK012 showed much stronger growth inhibitory effects than CPT-11 in all tested xenografted tumors, such as Co-3, HT-29, DLD-1 colon cancer, 4-1ST, ST-4 gastric cancer, and L-27 non-small cell lung cancer. Maximum tolerated dose (MTD) (67 mg/kg/day, q4dx3) of CPT-11 produced moderate tumor growth inhibition, which could be achieved with NK012 at 3.75 - 7.5 mg/kg/day by q4dx3 (1/5 - 1/10th of CPT-11 as EHC equivalent). As MTD of NK012 is 30 mg/kg/day by q4dx3, therapeutic window of NK012 is quite large, and MTD of NK012 exhibited sustained regression of tumor volume even of the CPT-11-insensitve tumors, HT-29, DLD-1 and L-27. Against rat mammary tumor MRMT-1, CPT-11 showed only slight efficacy even at the minimum lethal dose, although diarrhea, neutropenia and thrombocytopenia appeared apparently. On the contrary, NK012 exhibited significant antitumor activity with wide dose range from 10 to 30 mg/kg/day by q7dx3 without inducing diarrhea. Neutropenia was observed in NK012-treated rats from 10 mg/kg/day, but it could recover quickly. The pharmacokinetic studies of NK012 and CPT-11 were performed using HT-29 bearing nude mice and MRMT-1 bearing rats. After single injection of therapeutic dose of NK012, prolonged high levels of both polymer-conjugated EHC and free EHC were observed over 7 days in tumor tissue as well as in plasma. On the other hand, in the case of CPT-11, EHC converted from CPT-11 disappeared rapidly from tumor tissue. The significant increase in exposure time and concentration of released EHC in these tumors explains well superior antitumor activity of NK012 to CPT-11. These results indicate that NK012, EHC-incorporating micellar nanoparticle, exploits therapeutic benefit of EHC over CPT-11, and suggest that NK012 is a promising clinical candidate for treatment of various cancers. The phase I study of NK012 will start soon in Japan.
European consensus conference on faecal microbiota transplantation in clinical practice
Authors: Giovanni Cammarota, Gianluca Ianiro, Herbert Tilg, Mirjana Rajilić-Stojanović, Patrizia Kump, Reetta Satokari, Harry Sokol, Perttu Arkkila, Cristina Pintus, Ailsa Hart, Jonathan Segal, Marina Aloi, Luca Masucci, Antonio Molinaro, Franco Scaldaferri, Giovanni Gasbarrini, Antonio Lopez-Sanroman, Alexander Link, Pieter de Groot, Willem M de Vos, Christoph Högenauer, Peter Malfertheiner, Eero Mattila, Tomica Milosavljević, Max Nieuwdorp, Maurizio Sanguinetti, Magnus Simren, Antonio Gasbarrini
Journal: Gut (2017)

Faecal microbiota transplantation (FMT) is an important therapeutic option for <i>Clostridium difficile</i> infection. Promising findings suggest that FMT may play a role also in the management of other disorders associated with the alteration of gut microbiota. Although the health community is assessing FMT with renewed interest and patients are becoming more aware, there are technical and logistical issues in establishing such a non-standardised treatment into the clinical practice with safety and proper governance. In view of this, an evidence-based recommendation is needed to drive the practical implementation of FMT. In this European Consensus Conference, 28 experts from 10 countries collaborated, in separate working groups and through an evidence-based process, to provide statements on the following key issues: FMT indications; donor selection; preparation of faecal material; clinical management and faecal delivery and basic requirements for implementing an FMT centre. Statements developed by each working group were evaluated and voted by all members, first through an electronic Delphi process, and then in a plenary consensus conference. The recommendations were released according to best available evidence, in order to act as guidance for physicians who plan to implement FMT, aiming at supporting the broad availability of the procedure, discussing other issues relevant to FMT and promoting future clinical research in the area of gut microbiota manipulation. This consensus report strongly recommends the implementation of FMT centres for the treatment of <i>C. difficile</i> infection as well as traces the guidelines of technicality, regulatory, administrative and laboratory requirements.
Bortezomib Enhances the Antitumor Activity of Adoptively Infused Natural Killer Cells In Vivo: A Novel Approach To Override KIR-Mediated Inhibition of NK Cell Cytotoxicity.
Authors: Andreas Lundqvist, Sheila Rao, Aleah Smith, Maria Berg, Su Su, Hisayuki Yokoyama, Shivani Srivastava, Richard Childs
Journal: Blood (2007)
Evaluation of Minimal Residual Disease Based on NPM1 Mutations in AML with Intermediate Risk Cytogenetics: A Prospective Study of 36 Patients.
Authors: Aline Renneville, Florence Pasquier, Selim Corm, Nathalie Philippe, Charikleia Kelaidi, Catherine Roche-Lestienne, Virginie Eclache, Gerard Michel, Sylvie Castaigne, Pierre Fenaux, Claude Preudhomme
Journal: Blood (2007)
Short Synthetic α‐Helical‐Forming Peptide Amphiphiles for Fungal Keratitis Treatment In Vivo
Authors: Hong Wu, Shaoqiong Liu, Nikken Wiradharma, Zhan Yuin Ong, Yan Li, Yi Yan Yang, Jackie Y. Ying
Journal: Advanced Healthcare Materials (2017)

The emergence of fungal keratitis is on the rise globally. However, current antifungal therapeutics are ineffective in severe keratomycosis. Previously reported α‐helical peptides comprising 8–14 amino acids demonstrate broad‐spectrum antimicrobial activity both in vitro and in vivo. Here, α‐helical peptides of the optimized sequences are investigated for antifungal biofilm in vitro and in vivo using a fungal biofilm‐caused mouse keratitis model. The peptides with the optimal composition demonstrate higher α‐helical propensity and improve antifungal activity in dispersing Candida albicans biofilm in vitro. Moreover, the optimized α‐helical peptides are not only effective in treating C. albicans biofilm‐induced keratitis in mice, they are also nontoxic to the mice eyes. These peptides have the potential to be developed as antifungal agents for the treatment of C. albicans biofilm‐caused keratitis.
State Laws Requiring Hand Sanitation Stations at Animal Contact Exhibits—United States, March–April 2016
Authors: Aila Hoss, Colin Basler, Lauren Stevenson, Kelly Gambino-Shirley, Misha Park Robyn, Megin Nichols
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

In the United States, animal contact exhibits, such as petting zoos and agricultural fairs, have been sources of zoonotic infections, including infections with Escherichia coli, Salmonella, and Cryptosporidium (1-4). The National Association of State Public Health Veterinarians recommends handwashing after contact with animals as an effective prevention measure to disease transmission at these exhibits (4). This report provides a list of states that have used law, specifically statutes and regulations, as public health interventions to increase hand sanitation at animal contact exhibits. The report is based on an assessment conducted by CDC's Public Health Law Program, in collaboration with the Division of Foodborne, Waterborne, and Environmental Diseases in CDC's National Center for Emerging and Zoonotic Infectious Diseases. The assessment found that seven states have used statutes or regulations to require hand sanitation stations at these exhibits (5). Jurisdictions seeking to improve rates of hand sanitation at animal contact exhibits can use this report as a resource in developing their own legal interventions.
Ligation of Toll-Like Receptor 5 (TLR5) by Flagellin Overcomes Antigen-Specific CD4+ T Cell Tolerance Via Inhibition of IL10 and Induction of IL12 in Antigen Presenting Cells (APCs).
Authors: Ildefonso Suarez, FengDong Cheng, Jason B. Brayer, HW Wang, Horna Pedro, Sotomayor M. Eduardo
Journal: Blood (2004)
Novel Three- and Four-Drug Combination Regimens of Bortezomib, Dexamethasone, Cyclophosphamide, and Lenalidomide, for Previously Untreated Multiple Myeloma: Results From the Multi-Center, Randomized, Phase 2 EVOLUTION Study
Authors: Shaji Kumar, Ian W. Flinn, Paul G Richardson, Parameswaran Hari, Natalie Scott Callander, Stephen J. Noga, A. Keith Stewart, Jonathan Glass, Robert M. Rifkin, Jeffrey L Wolf, Jose Estevam, George Mulligan, Hongliang Shi, Iain J. Webb, S. Vincent Rajkumar
Journal: Blood (2010)
Bcl2 Over-Expression as a Prognostic factor In Hodgkin Lymphoma Patients who Required Intensive Treatment
Authors: Gabriela Rodriguez-Macias, Jorge Gayoso, Leyre Bento, Isabel Gonzalez, Javier Menarguez, Pascual Balsalobre, Cristina Muñoz-Martinez, Patricia Font, Cristina Encinas, Santiago Osorio, Mi Kwon, David Serrano, Antonio Escudero, Jose Luis Diez-Martin
Journal: Blood (2010)
The Effect of Antiseptic on 99mTc-DMSA Scans
Authors: Tahereh Firuzyar, Tahereh Ghaedian
Journal: Clinical Nuclear Medicine (2017)

Approximately 30 years ago, it has been suggested that chlorhexidine, which is used as antiseptic, can produce 99mTc colloid complex during 99mTc–dimercaptosuccinic acid (DMSA) preparation. However, in all cases of liver and spleen uptake in 99mTc-DMSA scan, it should still be kept in mind because of the introduction of new antiseptic brands with different formulation under various names. Our case is just a sample of this effect, which resulted from application of a new brand of antiseptic by technologists in our center that unintentionally led to low-quality 99mTc-DMSA scans for a period, and after restrict control of all other confounding factors in the preparation of kit, it was just resolved by changing antiseptic to ethanol.
The Bioactive Polyphenol Curcumin (diferuloylmethane) In Human Apolipoprotein A-1 Nanodisks Enhances Apoptosis and G1 Cell Cycle Arrest In Mantle Cell Lymphoma Compared with Free Curcumin
Authors: Amareshwar T.K. Singh, Mistuni Ghosh, C. Shad Thaxton, Trudy M. Forte, Robert O. Ryan, Leo I. Gordon
Journal: Blood (2010)
Activation of Stem-Cell Specific Genes by HOXA9 and HOXA10 Homeodomain Proteins in CD34+ Human Cord Blood Cells.
Authors: H. Jeffrey Lawrence, Christina M. Ferrell, Sheri T. Dorsam, Hideaki Ohta, R. Keith Humphries, Mika K. Derynck, Chris Haqq, Corey Largman
Journal: Blood (2004)
Commentary: Working better, not harder
Authors: Jennifer Dixon
Journal: BMJ (2017)

Asking your medical friends how life is at work always provokes gripes, but the pressure the NHS is now under has hiked these to fever pitch. There is ample reason.

The NHS is under unprecedented budget constraint,1 staff are working flat out, under enormous pressure to protect patients and at great cost to themselves. Social care is at “tipping point.”2 The strain is uniquely challenging, and should not be underestimated.

Many working in clinical care feel fury: bitter blame is heaped on politicians, managers, commissioners, regulators; and there is a loud chorus for more money and staff, less bureaucracy and interference, and more support. If I want to be very unpopular, I ask medical colleagues if any are involved in management, and then bolt for the bunker because this often induces apoplexy. But …
A Phase 1 Study of Prasugrel in Subjects with Sickle Cell Disease: Impact on Ex Vivo Platelet Reactivity
Authors: Joseph A. Jakubowski, Chunmei Zhou, David S. Small, Kenneth J. Winters, D. Richard Lachno, Andrew L. Frelinger, Jo Howard, Stipo Jurcevic, Christopher D. Payne
Journal: Blood (2011)
ACUTE INFUSION OF A CONVERTING ENZYME-INHIBITOR (CEI) REVEALS AN INCREASED POST-GLOMERULAR RESISTANCE IN A RAT STRAIN SUSCEPTIBLE TO THE DEVELOPMENT OF GLOMERULOSCLEROSIS (GS)
Authors: Pj Westenend, Jfm Smits, Haj Struykerboudier, Jj Weening
Journal: Kidney International (1990)
Increased Risk of Thrombotic Events in Patients with Acute Promyelocytic Leukemia (APL) Receiving ATRA Treatment: Does It Correlate with CD2 and FLT3 Expression?.
Authors: Massimo Breccia, Roberto Latagliata, Ida Carmosino, Eleonora Russo, Mariella D’Andrea, Erica Finolezzi, Nicol Iorio, Cinzia Fazio, Giuseppe Avvisati, Maria Concetta Petti, Francesco Lo-Coco, Franco Mandelli
Journal: Blood (2005)
GAVIN: Gene-Aware Variant INterpretation for medical sequencing
Authors: K. Joeri van der Velde, Eddy N. de Boer, Cleo C. van Diemen, Birgit Sikkema-Raddatz, Kristin M. Abbott, Alain Knopperts, Lude Franke, Rolf H. Sijmons, Tom J. de Koning, Cisca Wijmenga, Richard J. Sinke, Morris A. Swertz
Journal: Genome biology (2017)

We present Gene-Aware Variant INterpretation (GAVIN), a new method that accurately classifies variants for clinical diagnostic purposes. Classifications are based on gene-specific calibrations of allele frequencies from the ExAC database, likely variant impact using SnpEff, and estimated deleteriousness based on CADD scores for >3000 genes. In a benchmark on 18 clinical gene sets, we achieve a sensitivity of 91.4% and a specificity of 76.9%. This accuracy is unmatched by 12 other tools. We provide GAVIN as an online MOLGENIS service to annotate VCF files and as an open source executable for use in bioinformatic pipelines. It can be found at http://molgenis.org/gavin .
Reduced Intensity Cord Blood Transplantation Using Mycophenolate Mofetil and Cyclosporine for Adult Patients with Advanced Hematologic Malignancies.
Authors: Tamae Hamaki, Koichi Kajiwara, Keiko Hoshi, Katsuhiro Kogure, Akane Harima, Kazunari Yamada, Hideki Kodo, Yasuji Kozai
Journal: Blood (2005)
Using National Inpatient Death Rates as a Benchmark to Identify Hospitals with Inaccurate Cause of Death Reporting — Missouri, 2009–2012
Authors: Jennifer Lloyd, Ehsan Jahanpour, Brian Angell, Craig Ward, Andy Hunter, Cherri Baysinger, George Turabelidze
Journal: MMWR Morbidity and Mortality Weekly Report (2017)

Reporting causes of death accurately is essential to public health and hospital-based programs; however, some U.S. studies have identified substantial inaccuracies in cause of death reporting. Using CDC's national inpatient hospital death rates as a benchmark, the Missouri Department of Health and Senior Services (DHSS) analyzed inpatient death rates reported by hospitals with high inpatient death rates in St. Louis and Kansas City metro areas. Among the selected hospitals with high inpatient death rates, 45.8% of death certificates indicated an underlying cause of death that was inconsistent with CDC's Guidelines for Death Certificate completion. Selected hospitals with high inpatient death rates were more likely to overreport heart disease and renal disease, and underreport cancer as an underlying cause of death. Based on these findings, the Missouri DHSS initiated a new web-based training module for death certificate completion based on the CDC guidelines in an effort to improve accuracy in cause of death reporting.
Abstract 11171: Epicardial NADH Fluorescence Images Correlate With Lesion Size and Predict Lesion Depth After Radiofrequency Ablation
Authors: David Cohen, Luther Swift, Kulin Shah, Dan Gil, Matthew Kay, Arnold Schwartz, Narine Sarvazyan, Marco Mercader
Journal: Circulation (2013)

Introduction: Arrhythmia recurrence after catheter ablation for atrial fibrillation (AF) has been linked to conduction gaps at pulmonary vein isolation lines. Our lab has shown that NADH imaging ca...
Nilotinib in Patients (pts) with Relapsed/Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL) Who Are Resistant or Intolerant to Imatinib.
Authors: Oliver G. Ottmann, Richard A. Larson, Hagop M. Kantarjian, Philipp le Coutre, Michele Baccarani, Ariful Haque, Neil Gallagher, Francis Giles
Journal: Blood (2007)
Sentinel surveillance of imported dengue via travellers to Europe 2012 to 2014: TropNet data from the DengueTools Research Initiative
Authors: Andreas Neumayr, Jose Muñoz, Mirjam Schunk, Emmanuel Bottieau, Jakob Cramer, Guido Calleri, Rogelio López-Vélez, Andrea Angheben, Thomas Zoller, Leo Visser, Núria Serre-Delcor, Blaise Genton, Francesco Castelli, Marjan Van Esbroeck, Alberto Matteelli, Laurence Rochat, Elena Sulleiro, Florian Kurth, Federico Gobbi, Francesca Norman, Ilaria Torta, Jan Clerinx, David Poluda, Miguel Martinez, Antonia Calvo-Cano, Maria Paz Sanchez-Seco, Annelies Wilder-Smith, Christoph Hatz, Leticia Franco
Journal: Eurosurveillance (2017)

We describe the epidemiological pattern and genetic characteristics of 242 acute dengue infections imported to Europe by returning travellers from 2012 to 2014. The overall geographical pattern of imported dengue (South-east Asia > Americas > western Pacific region > Africa) remained stable compared with 1999 to 2010. We isolated the majority of dengue virus genotypes and epidemic lineages causing outbreaks and epidemics in Asia, America and Africa during the study period. Travellers acted as sentinels for four unusual dengue outbreaks (Madeira, 2012-13; Luanda, 2013; Dar es Salaam, 2014; Tokyo, 2014). We were able to characterise dengue viruses imported from regions where currently no virological surveillance data are available. Up to 36% of travellers infected with dengue while travelling returned during the acute phase of the infection (up to 7 days after symptom onset) or became symptomatic after returning to Europe, and 58% of the patients with acute dengue infection were viraemic when seeking medical care. Epidemiological and virological data from dengue-infected international travellers can add an important layer to global surveillance efforts. A considerable number of dengue-infected travellers are viraemic after arrival back home, which poses a risk for dengue introduction and autochthonous transmission in European regions where suitable mosquito vectors are prevalent.