tbuckley/cabot-search huggingface dataset:
A feasibility trial of geriatric assessment and integrated care plan for older cancer patients.
Authors: Martine Puts, Schroder Sattar, Kara McWatters, Katharine Lee, Eitan Amir, Monika K. Krzyzanowska, Anthony M Joshua, Johanne Monette, Doreen Wan-Chow-Wah, Raymond Woo-Jun Jang, Shabbir M.H. Alibhai
Journal: Journal of Clinical Oncology (2015)

TPS9634 Background: The majority of persons diagnosed with cancer are older adults. A comprehensive geriatric assessment (CGA) can identify current health care issues, start interventions to prevent/postpone adverse outcomes and maintain/improve the functional status and well-being of older adults. However, there is limited and conflicting evidence to support the effectiveness of CGA in oncology settings. Here, we explore the impact of a CGA and integrated care plan in optimizing outcomes in older patients with advanced breast (BC), gastrointestinal (GI) or genitourinary (GU) cancer Methods: A two-group parallel single-blind phase II RCT is enrolling 60 patients aged 70 years and over, diagnosed with GI, GU or BC, referred for first line chemotherapy or having received < 2cycles ( < 6weeks) of chemotherapy at Princess Margaret Cancer Centre. Patients need to be fluent in English, have a life expectancy > 6 months, ECOG PS 0-2 and able to provide informed consent. Randomization to intervention and control group is 1:1 and stratified by treatment intent (adjuvant vs. palliative). The intervention includes a full CGA by a multidisciplinary geriatric team followed by an integrated care plan to address the issues identified. Based on the CGA and discussion with the patient, tailored evidence-based interventions will be carried out by the team using a standardized intervention protocol. Participants in the intervention group are seen by the intervention team at baseline for the CGA and development of the integrated care plan; and at 3 and 6 months to assess intervention fidelity and measure outcomes. The co-primary outcomes are: 1) Maintaining/improving quality of life (EORTC QLQ-C30); 2) Modification of the cancer treatment plan. The secondary outcomes are: 1) Functional status (OARS Instrumental Activities of Daily Living); and 2) Feasibility of the study by tumor site. 15 of 60 planned patients have been enrolled to date. This will be one of the first RCTs of CGA in geriatric oncology to show feasibility and provide estimates of impact on relevant outcomes to inform the design of a phase 3 trial. Clinical trial information: NCT02222259.
Elevated Myocardial Creatine Protects Against Ischemia/Reperfusion Injury by Improving Cardiac Energetics
Authors: C A Lygate, S Bohl, M ten Hove, D J Medway, L Sebag-Montefiore, S Zervou, D Aksentijevic, K M Faller, K Clarke, H Watkins, J E Schneider, S Neubauer
Journal: Circulation (2011)
Early Treatment Intensification with R-ICE Chemotherapy Followed By Autologous Stem Cell Transplantation (ASCT) Using Zevalin-BEAM for Patients with Poor Risk Diffuse Large B-Cell Lymphoma (DLBCL) As Identified By Interim PET/CT Scan Performed after Four Cycles of R-CHOP-14: A Multicenter Phase II Study of the Australasian Leukaemia Lymphoma Study Group (ALLG)
Authors: Mark S Hertzberg, Maher K Gandhi, Belinda Butcher, Ruth Columbus, John Taper, Judith Trotman, Devinder Gill, Shir-Jing Ho, Keith Fay, Gavin Cull, Andrew P Grigg, Geoff Chong, Ian D. Lewis, Sam Milliken, William Renwick, Uwe Hahn, Robin Filshie, Anne-Marie Watson, George Kannourakis, Max Wolf, Andrew Wirth, Pauline Therese Warburton, Stephen Robert Larsen, John F. Seymour, Rodney Hicks
Journal: Blood (2015)
EFICACIA Y SEGURIDAD DE LAS DILATACIONES ENDOSCÓPICAS EN LA ENFERMEDAD INFLAMATORIA INTESTINAL: RESULTADOS DEL REGISTRO ENEIDA
Authors: X Andújar, C Loras, M Socarras, E Rodríguez, B Sicilia, X Calvet, J Barrio, J Guardiola, J Casanova Maria, M Esteve
Journal: Endoscopy (2015)

Introducción: Dilatación endoscópica con balón (DEB) es tratamiento endoscópico de elección para estenosis cortas en Enfermedad de Crohn (EC). Estudios observacionales no controlados han demostrado que DEB, es una alternativa segura y eficaz a la cirugía.
Reconstitution of Lymphocyte Subsets and Outcomes After Matched and Mismatched Hematopoietic Stem-Cell Transplantation
Authors: Antonio Di Stasi, Michelle Poon, Amir Hamdi, Hila Shaim, Susan Xie, Denai Milton, Roland Bassett, Gabriela Rondon, Elizabeth J. Shpall, Laurence Cooper, Dean Lee, Katy Rezvani, Richard E. Champlin, Stefan O. Ciurea
Journal: Blood (2012)
Funding for Biomedical Research
Authors: Joel Kupersmith, Jonathan Brian Perlin
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Lung disease caused by<i>ABCA3</i>mutations
Authors: Carolin Kröner, Thomas Wittmann, Simone Reu, Veronika Teusch, Mathias Klemme, Daniela Rauch, Meike Hengst, Matthias Kappler, Nazan Cobanoglu, Tugba Sismanlar, Ayse T Aslan, Ilaria Campo, Marijke Proesmans, Thomas Schaible, Susanne Terheggen-Lagro, Nicolas Regamey, Ernst Eber, Jürgen Seidenberg, Nicolaus Schwerk, Charalampos Aslanidis, Peter Lohse, Frank Brasch, Ralf Zarbock, Matthias Griese
Journal: Thorax (2016)

<h3>Background</h3> Knowledge about the clinical spectrum of lung disease caused by variations in the ATP binding cassette subfamily A member 3 (ABCA3) gene is limited. Here we describe genotype-phenotype correlations in a European cohort. <h3>Methods</h3> We retrospectively analysed baseline and outcome characteristics of 40 patients with two disease-causing ABCA3 mutations collected between 2001 and 2015. <h3>Results</h3> Of 22 homozygous (15 male) and 18 compound heterozygous patients (3 male), 37 presented with neonatal respiratory distress syndrome as term babies. At follow-up, two major phenotypes are documented: patients with (1) early lethal mutations subdivided into (1a) dying within the first 6 months or (1b) before the age of 5 years, and (2) patients with prolonged survival into childhood, adolescence or adulthood. Patients with null/null mutations predicting complete ABCA3 deficiency died within the 1st weeks to months of life, while those with null/other or other/other mutations had a more variable presentation and outcome. Treatment with exogenous surfactant, systemic steroids, hydroxychloroquine and whole lung lavages had apparent but many times transient effects in individual subjects. <h3>Conclusions</h3> Overall long-term (&gt;5 years) survival of subjects with two disease-causing ABCA3 mutations was &lt;20%. Response to therapies needs to be ascertained in randomised controlled trials.
Primary Care as Part of US Health Services Reform
Authors: Steven L. Oreck
Journal: JAMA (1993)

<h3>To the Editor.</h3> —In their discussion of restructuring licensing policies, Starfield and Simpson<sup>1</sup>essentially state that the government or some other monitoring body should determine whether or not a physician in a given specialty is allowed to go into a practice within a specified area based on statistics of case mix and the like. It is unprecedented, un-American, and probably unconstitutional for the government to direct people where to live. There is no difficulty with the government using incentives to try to direct professionals to an area where it is felt they may be needed and away from areas where it is felt that they are not needed. To deny any American the right to live and attempt to practice their profession where they will is anathema and invalidates the entire program.
Use of Digitally Stained Multimodal Confocal Mosaic Images to Screen for Nonmelanoma Skin Cancer
Authors: Euphemia W. Mu, Jesse M. Lewin, Mary L. Stevenson, Shane A. Meehan, John A. Carucci, Daniel S. Gareau
Journal: JAMA Dermatology (2016)

<h3>Importance</h3> Confocal microscopy has the potential to provide rapid bedside pathologic analysis, but clinical adoption has been limited in part by the need for physician retraining to interpret grayscale images. Digitally stained confocal mosaics (DSCMs) mimic the colors of routine histologic specimens and may increase adaptability of this technology. <h3>Objective</h3> To evaluate the accuracy and precision of 3 physicians using DSCMs before and after training to detect basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in Mohs micrographic surgery fresh-tissue specimens. <h3>Design</h3> This retrospective study used 133 DSCMs from 64 Mohs tissue excisions, which included clear margins, residual BCC, or residual SCC. Discarded tissue from Mohs surgical excisions from the dermatologic surgery units at Memorial Sloan Kettering Cancer Center and Oregon Health &amp; Science University were collected for confocal imaging from 2006 to 2011. Final data analysis and interpretation took place between 2014 and 2016. Two Mohs surgeons and a Mohs fellow, who were blinded to the correlating gold standard frozen section diagnoses, independently reviewed the DSCMs for residual nonmelanoma skin cancer (NMSC) before and after a brief training session (about 5 minutes). The 2 assessments were separated by a 6-month washout period. <h3>Main Outcomes and Measures</h3> Diagnostic accuracy was characterized by sensitivity and specificity of detecting NMSC using DSCMs vs standard frozen histopathologic specimens. The diagnostic precision was calculated based on interobserver agreement and κ scores. Paired 2-sample<i>t</i>tests were used for comparative means analyses before and after training. <h3>Results</h3> The average respective sensitivities and specificities of detecting NMSC were 90% (95% CI, 89%-91%) and 79% (95% CI, 52%-100%) before training and 99% (95% CI, 99%-99%) (<i>P</i> = .001) and 93% (95% CI, 90%-96%) (<i>P</i> = .18) after training; for BCC, they were 83% (95% CI, 59%-100%) and 92% (95% CI, 81%-100%) before training and 98% (95% CI, 98%-98%) (<i>P</i> = .18) and 97% (95% CI, 95%-100%) (<i>P</i> = .15) after training; for SCC, they were 73% (95% CI, 65%-81%) and 89% (95% CI, 72%-100%) before training and 100% (<i>P</i> = .004) and 98% (95% CI, 95%-100%) (<i>P</i> = .21) after training. The pretraining interobserver agreement was 72% (κ = 0.58), and the posttraining interobserver agreement was 98% (κ = 0.97) (<i>P</i> = .04). <h3>Conclusions and Relevance</h3> Diagnostic use of DSCMs shows promising correlation to frozen histologic analysis, but image quality was affected by variations in image contrast and mosaic-stitching artifact. With training, physicians were able to read DSCMs with significantly improved accuracy and precision to detect NMSC.
Physician Practice Style Variation—Implications for Policy
Authors: Jessica Van Parys, Jonathan Skinner
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Security of Personal Information in a New Health Care System-Reply
Authors: Lawrence O. Gostin
Journal: JAMA (1994)

<h3>In Reply.</h3> —Mr Stevens expresses a generalized concern about the role of the federal government in a "nationalized medicine proposal," presumably referring to President Clinton's health system reform bill. Rather than engage in a debate over the role of government in ensuring universal access to health care, it is more appropriate to examine the central questions raised in the<i>JAMA</i>article—can systematic collection of information improve the quality of health care services and is it appropriate to enact federal legislation to protect informational privacy? Systematic collection of uniform data sets proposed in the American Health Security Act is intended to achieve a number of desirable outcomes for consumers. The data will be used to objectively evaluate the quality of services offered by health plans; provide better information to consumers in choosing health plans; conduct health services, biomedical, and epidemiological research; prevent fraud and abuse; and track the spread of disease
Haploidentical Hematopoietic Cell Transplantation (HCT) Compared with Matched HCT from Family Donors: report of 216 cases.
Authors: Daopei Lu, Wei Han, Lujia Dong, Xiaojun Huang, Kaiyan Liu, Huan Chen, Lanping Xu, Hanyun Ren, Daihong Liu, Yuhong Chen, Tong Wu, Jin Lu, Zhiyong Gao, Jingbo Wang, Qian Jiang, Yaochen Zhang, Jingzhi Wang
Journal: Blood (2004)
Abstract 13447: An Injectable Conductive Polymer Hydrogel Improves Electrical Conduction Velocity in the Injured Heart
Authors: Zhi Cui, Nathan C Ni, Jun Wu, Terrence M Yau, Richard D Weisel, Ren-Ke Li
Journal: Circulation (2015)

Introduction: Scar formation after a myocardial infarction (MI) delays electrical impulse propagation, inducing dysynchronous cardiac activation and uncoordinated contraction. We generated an injectable biocompatible conductive polymer that not only stabilized the infarct region, but also facilitated electrical signal propagation across the scar tissue to enhance synchronous ventricular contraction. Methods/Results: Oxidative polymerization was employed to conjugate polypyrrole (PPY) to chitosan (CHI) and hydrogels were created by glutaraldehyde crosslinking. Biomaterials with 4 different PPY:CHI ratios (CHI, 3PPY:10CHI, 3 PPY:100 CHI, 3 PPY:1000CHI ) were generated. Electrical conductivity was measured by two-probe cyclic voltammetry. The 3PPY:10CHI ratio had significantly greater conductivity than the other concentrations (2.37х10-4±6.25х10-5S/cm, n=6, P&lt;0.05). Improved electrical propagation was demonstrated when neonatal rat cardiomyocytes cultured on 3PPY:10CHI had significantly higher Ca2+ transient propagation velocity (by optical mapping with a fluo-4/AM indicator) than those cultured on other concentrations (17.25±2.23cm/s, n=15, P&lt;0.05). Thus, 3PPY:10CHI was employed for in vivo studies employing a cryoinjury model (with a uniform scar size). Saline, CHI, and 3PPY:10CHI were injected into Sprague-Dawley rat hearts 1 week after injury. The sequence of cardiac electrical activation was visualized using an optical mapping system 1 month post-injection. Saline (57.7±2.5cm/s, n=4)- and CHI (47.1±3.5cm/s, n=3)-injected hearts showed disrupted propagation patterns and significantly reduced conduction velocity, while 3PPY:10CHI (74.3±4.7cm/s, n=5)-treated hearts had higher conduction velocities that were similar to healthy controls (81.3±0.59cm/s, n=3). Conclusion: A polypyrrole-conjugated chitosan hydrogel supported cell attachment and improved electrical conductivity in vitro. The 3PPY:10CHI biomaterial enhanced Ca2+ transient propagation in cultured cardiomyocytes and intra-myocardial injection of the material improved longitudinal electrical impulse propagation across the scar. This new biomaterial may be a new potential therapy to synchronize cardiac contraction.
Aspecific Uptake of 68GA-PSMA in Paget Disease of the Bone
Authors: Sophie Bourgeois, Pieterjan Gykiere, Lode Goethals, Hendrik Everaert, Frank W. De Geeter
Journal: Clinical Nuclear Medicine (2016)

Ga-PSMA plays an increasing role in prostate cancer management, but several instances of false positivity have now been recognized. We present a patient with metastatic prostatic carcinoma who also showed overexpression of PSMA in Paget disease of the humerus on Ga-PSMA PET. This probably relates to bone remodeling and increased vascularity. It is important to be aware of this aspecific uptake because its recognition may avoid overstaging and may alter the therapeutic choice.
Incidence of Programmed Cell Death 1 Inhibitor–Related Pneumonitis in Patients With Advanced Cancer
Authors: Mizuki Nishino, Anita Giobbie-Hurder, Hiroto Hatabu, Nikhil H. Ramaiya, F. Stephen Hodi
Journal: JAMA Oncology (2016)

Programmed cell death 1 (PD-1) inhibitor-related pneumonitis is a rare but clinically serious and potentially life-threatening adverse event. Little is known about its incidence across different tumor types and treatment regimens.To compare the incidence of PD-1 inhibitor-related pneumonitis among different tumor types and therapeutic regimens.A PubMed search through November 10, 2015, and a review of references from relevant articles. For the PubMed search, the following keywords or corresponding Medical Subject Heading terms were used: nivolumab, pembrolizumab, and PD-1 inhibitor.Twenty-six original articles of PD-1 inhibitor trial results were identified. Among them, 20 studies of melanoma, non-small cell lung cancer (NSCLC), or renal cell carcinoma (RCC) were eligible for a meta-analysis.The data were extracted by 1 primary reviewer and then independently reviewed by 2 secondary reviewers following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Comparisons of the incidence were based on marginal, exact generalized linear models with generalized estimating equations.Incidence of all-grade and grade 3 or higher pneumonitis and pneumonitis-related deaths.Twenty studies of single-tumor-type trials of PD-1 inhibitor (12 melanoma studies, 5 NSCLC studies, and 3 RCC studies) (a total of 4496 unique patients) were included in the meta-analysis. The overall incidence of pneumonitis during PD-1 inhibitor monotherapy was 2.7% (95% CI, 1.9%-3.6%) for all-grade and 0.8% (95% CI, 0.4%-1.2%) for grade 3 or higher pneumonitis. The incidence was higher in NSCLC for all-grade (4.1% vs 1.6%; P = .002) and grade 3 or higher pneumonitis (1.8% vs 0.2%; P < .001) compared with melanoma. The incidence in RCC was higher than in melanoma for all-grade pneumonitis (4.1% vs 1.6%; P < .001) but not for grade 3 or higher pneumonitis. Four pneumonitis-related deaths were observed in patients with NSCLC in the monotherapy group. Pneumonitis was more frequent during combination therapy than monotherapy for all-grade (6.6% vs 1.6%; P < .001) and grade 3 or higher pneumonitis (1.5% vs 0.2%; P = .001) in melanoma, with 1 pneumonitis-related death during combination therapy. Multivariable analyses demonstrated higher odds of pneumonitis in NSCLC for all-grade (odds ratio [OR], 1.43; 95% CI, 1.08-1.89; P = .005) and grade 3 or higher pneumonitis (OR, 2.85; 95% CI, 1.60-5.08; P < .001) and in RCC for all-grade pneumonitis (OR, 1.59; 95% CI, 1.32-1.92; P < .001) compared with melanoma. The combination therapy had significantly higher odds than monotherapy for all-grade (OR, 2.04; 95% CI, 1.69-2.50; P < .001) and grade 3 or higher pneumonitis (OR, 2.86; 95% CI, 1.79- 4.35; P < .001).The incidence of PD-1 inhibitor-related pneumonitis was higher in NSCLC and RCC and during combination therapy. These findings contribute to enhance awareness among clinicians and support further investigations to meet the clinical needs.
Preimplantation Diagnosis of the Cystic Fibrosis ΔF508 Mutation: What of the Other Two Embryos?-Reply
Authors: Willy Lissens
Journal: JAMA (1995)

In Reply.  —Drs Callahan and Person raise points of discussion to which, we are afraid, no clear-cut answers can be given. Opinions about life and health differ among different people. As long as one of us does not claim to know what is best for the other and as long as everybody respects one another, humankind will remain on the right track. We hope that Callahan and Person can accept the premise that for some of us an embryo is already a person, while for others it is, especially in the very early developmental stages, only a potential human being. In particular, the embryos referred to in our article are at the eight-cell stage. Along the same lines, we and others are convinced of doing good by preventing a child-to-be from being sick, but this does not imply that children who are born sick are considered inferior.  As a matter
ETV6/RUNX1-Postitive Childhood Acute Lymphoblastic Leukemia (ALL): Do Additional Aberrations Influence Treatment Response and Outcome?
Authors: Maria Ampatzidou, Stephanos I. Papadhimitriou, George Paterakis, Loizos Petrikkos, Dimitrios Pavlidis, Konstantinos Tsitsikas, Vassilios Papadakis, George Vassilopoulos, Sophia Polychronopoulou
Journal: Blood (2014)
Clinical and Immunological Response Following hTERT/Survivin mRNA-Loaded Dendritic Cell Vaccination Combined With Ex-Vivo Expanded T Cell Transfer In Melanoma Patients
Authors: Gunnar Kvalheim, Iris Bigalke, Siri Torhaug, Marianne Lundby, Camilla Mollat, Else-Marit Inderberg Suso, Arne Kolstad, Gustav Gaudernack, Anne-Marie Rasmussen, Steinar Aamdal
Journal: Blood (2013)