tbuckley/cabot-search huggingface dataset:
Abstract 1998: Aberrant methylation of BRCA/HR pathway genes and response to platinum-taxane therapy in ovarian cancer
Authors: Marie E. Maradeo, Mark A. Morgan, Robert A. Burger, Paul Cairns
Journal: Cancer Research (2011)

Abstract Women diagnosed with ovarian cancer generally receive debulking surgery in combination with platinum-taxane based chemotherapy. While this treatment is currently the most effective, women diagnosed with Stage III and IV ovarian cancer have a less than a 20% five-year survival rate. Ovarian tumorigenesis is a multi-step process that results from the sequential accumulation, and interplay, of genetic and epigenetic mutations in critical genes. It is likely that such mutations underlie the different responses to therapy. There are several reports that demonstrate that women with germline mutations in BRCA genes and inherited ovarian cancer have a favorable survival as compared to women with sporadic ovarian cancer that is matched for pathological stage. The BRCA1 and BRCA2 genes function to repair DNA damage and maintain genetic stability through the homologous recombination (HR) repair pathway. Much of the superior survival is likely due to hypersensitivity to platinum-containing chemotherapy that in turn is due to incompetent DNA repair of platinum DNA adducts due to faulty HR repair of double stranded DNA breaks (DSBs). It is hypothesized that sporadic ovarian tumors, which constitute the vast majority of ovarian cancer, with epigenetic suppression of BRCA or BRCA-associated proteins, e.g. aberrant promoter hypermethylation of BRCA1, will be relatively hypersensitive to platinum as compared to ovarian tumors with an intact BRCA/HR pathway. To answer this important question, we have used bisulfite sequencing and quantitative methylation specific PCR to examine the incidence of epigenetic impairment of BRCA/HR pathway genes, including BRCA1, PALB2 and other genes, in primary human epithelial ovarian cancer and, using these results, then examined the relative frequency of BRCA/HR pathway impairment in sporadic ovarian tumors separated into cohorts by time to progression after platinum-taxane therapy and other measures of outcome. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1998. doi:10.1158/1538-7445.AM2011-1998
Abstract 2374: Integrin-linked kinase (ILK) promotes melanoma angiogenesis by activating IL-6 signaling pathway
Authors: Aijaz A. Wani, Gang Li
Journal: Cancer Research (2010)

Abstract Integrin-linked kinase (ILK) is a highly conserved serine-threonine protein kinase involved in cell-ECM interactions, cytoskeletal organization, and cell signaling. Overexpression of ILK in epithelial cells leads to anchorage-independent growth with increased cell cycle progression. Previously, we have shown that ILK upregulation strongly correlates with melanoma progression, invasion and inversely correlates with 5-year survival of melanoma patients. We also found that ILK knockdown impeded melanoma cell migration, invasion and impaired the growth of melanoma xenografts in severe combined immunodeficient (SCID) mice. However, the molecular mechanism by which ILK enhances melanoma angiogenesis is currently unknown. In the present study, we found that pro-angiogenic molecule interleukin-6 (IL-6) is the downstream transcriptional target of ILK in melanoma cells. ILK overexpression increased IL-6 whereas shRNA mediated silencing of ILK suppressed IL-6 expression both transcriptionally and translationally. By electromobility shift assays, we found that ILK enhanced the binding of transcription factor (NF-κB) to IL-6 promoter and this binding was reduced in ILK knockdown cells. Furthermore, Conditioned media (CM) from ILK- overexpressing cells enhanced the tube forming ability of HUVEC cells in vitro. This tube formation by HUVEC cells was IL-6 dependent as CM from IL6-siRNA treated ILK-overexpressing melanoma cells inhibited the tube formation of HUVEC cells. In order to delineate the mechanism by which ILK-upregulated IL-6 can enhance the growth of endothelial cells, further analysis of the downstream targets of IL-6 signaling showed an increase in activity and nuclear translocation of STAT3 in ILK-overexpressing cells. As STAT3 binds to VEGF promoter, we found that VEGF levels were elevated in ILK-overexpressing cells and declined in ILK knockdown cells, suggesting that ILK may regulate VEGF expression through IL-6 pathway by upregulating and activating STAT3. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2374.
SP0165 Involving patients as partners in their care - the nurse perspective
Authors: M. Kildemand
Journal: Annals of the Rheumatic Diseases (2013)

In 2003 key players from the Danish health care system made a report called <i>“The patient’s meeting with the health care system - interpersonal relationships - recommendations for communication, participation and Continuity”.</i> The working group consisted among others of The Danish Medical Association, The Council of Danish Nurses and a number of different patient associations. The purpose of the report was to ensure the quality of the interpersonal relationships in the patient’s meeting with the health care system. In the report there are 20 recommendations to health care professionals, which can be used as guidelines to how we meet and involve patients in their care. The recommendations are adapted into our daily work, as an inspiration to how we cooperate with the patients. It is very important for us that we meet patients with a friendly, open minded attitude for them to feel safe and free to take part in decisions concerning their care. We see the patients as partners in their own care. The health care professionals have information about the disease and treatments and know how to help patients in a crisis. The patients, however, have the knowledge on how the disease affects them, how the medicine influences their lives, and how they feel inside. By bringing both sides into the care, we see the patient as a whole person and not just as a disease case. From the nurse’s perspective this way of thinking may take some extra time in the daily work schedule, but it is worth while when you observe how patients get better physically and mentally, one step at a time, with us by their side. To ensure that our department continuous develops in accordance with patients’ wishes and needs, we have established a user council consisting of patients, doctors, nurses and representatives from the Danish Rheumatism Association. The participants meet on equal terms and thereby the patients become important collaborators. Mail: Malene.kildemand@ouh.regionsyddanmark.dk <h3>Disclosure of Interest</h3> None Declared
How safe is EUS performed by an endosonographer trained at a North American advanced training program recognized by ASGE and has met the ASGE guidelines for EUS competency? Results from the first 100 procedures performed after training
Authors: R Rego
Journal: Endoscopy (2006)

Aim: To determine the safety of EUS when performed by the “relatively inexperienced“ endosonographer who has completed advanced training in EUS at a North American training program recognized by ASGE and has met ASGE guidelines for EUS competency.
Prognostic Importance of 18F-FDG Uptake Pattern of Hepatocellular Cancer Patients Who Received SIRT
Authors: Ozlem N. Kucuk, Cigdem Soydal, Mine Araz, Sadik Bilgic, Erkan Ibis
Journal: Clinical Nuclear Medicine (2013)

The aim of the study was to evaluate the effect of 18F-FDG uptake pattern of liver lesions to treatment response of patients who received yttrium-90 (Y-90) selective internal radiation therapy (SIRT) for hepatocellular cancer (HCC).Nineteen patients (5F, 14M, mean age: 64.5 ± 14.7 years old, range: 57-73 years) who received SIRT treatment in our department for HCC between June 2008 and May 2011 were included in the study. All patients underwent 18F-FDG PET/CT before SIRT for evaluation of disease stage and metabolic activity of liver lesions. Patients were divided into 3 groups according to FDG uptake patterns of primary liver lesions (hypoactive, nonhomogenous, and focal intense). Progression-free survival (PFS) times of each group and patients with hepatic only and hepatic with extrahepatic disease were analyzed. Disease progression criteria were increase in tumor volume, progressive elevation of serum alpha-fetoprotein levels, and detection of extrahepatic metastases. Kaplan-Meier analysis was used for comparison of PFS times.The mean treatment dose was calculated as 1.4 ± 1.0 GBq. While liver lesions of 4 patients were hypoactive in pretreatment 18F-FDG PET/CT, liver lesions of 6 and 9 patients had nonhomogenous and intense FDG uptake, respectively. Mean PFS time of patients who had hypoactive liver lesions was 5.25 ± 1.52 months. In patients who had liver lesions with nonhomogenous uptake, mean PFS time was 12.3 ± 2.6 months. Lastly, in patients with intense uptake in liver lesions, PFS time was calculated as 19.8 ± 5.0 months. Difference between each group was statistically significant (P = 0.017). There was no significant difference in the PFS of the patients with limited hepatic disease and patients with extrahepatic involvement.In patients with unresectable HCC, higher SUVmax lesions unexpectedly had better PFS rates after SIRT, suggesting SIRT has a treatment advantage over other therapeutic options in these patients.
Chronobiology: Timing May Optimize Treatments
Authors: J. Corliss
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Chronobiology: Timing May Optimize Treatments Get access Julie Corliss Julie Corliss Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 23, 6 December 1989, Pages 1768–1769, https://doi.org/10.1093/jnci/81.23.1768 Published: 06 December 1989
PTU-185 What is the Cost of Duodenal Biopsies in Patients without Serological Evidence of Coeliac Disease?
Authors: B T Theron, D Williams, G Moran
Journal: Gut (2013)

<h3>Introduction</h3> The BSG guidelines recommend anti tissue transglutaminase antibody (TTG) testing as a first line test for coeliac disease. Duodenal biopsies (D2) should be performed only after a positive serological test or a negative test with a high clinical suspicion. We aimed to analyse whether the indications for duodenal biopsies and current practise are in keeping with guidelines. <h3>Methods</h3> This was a retrospective review of the electronic records of 171 consecutive patients who had had duodenal biopsies. <h3>Results</h3> The indications for endoscopy were iron deficiency anaemia (IDA) (51%), weight loss (16%), diarrhoea (3%) and non-specific gastrointestinal symptoms (30%). Seventy (41%) patients had a TTG done prior to endoscopy, 5 patients (2.9%) had a positive TTG prior to a positive D2 biopsy. Sixty-five (38%) patients had D2 biopsies despite a negative TTG. Hundred and one patients (69%) patients had D2 biopsies without any serological testing prior to endoscopy (1 positive biopsy). Nine (5.26%) patients had a TTG checked despite negative histology. The excess cost incurred: for processing biopsies after a negative TTG was £3139.50 and TTG after negative histology was £126.£3430 would have been saved by carrying a TTG test in subjects having a negative biopsy. <h3>Conclusion</h3> A significant proportion of duodenal biopsies are done in patients with a negative TTG. The diagnostic yield for coeliac disease in those with a negative TTG was zero. If BSG guidelines were adhered to, £6695 would have been saved in this cohort. <h3>Disclosure of Interest</h3> None Declared.
Abstract 1299: PHD3 has a key role in survival and proliferation of renal carcinoma cells
Authors: Byeong Woo Park, Kyung-Sup Kim, Seho Park, Hyung Seok Park, Lee-Su Kim
Journal: Cancer Research (2012)

Abstract Prolyl hydroxylase domain-containing protein3 (PHD3) is one of enzymes catalyzing proline-hydroxylation of hypoxia inducible factor(HIF)α- subunits, which is key regulatory event of HIF activity. In renal cell carcinoma (RCC) tissues, PHD3 is commonly expressed at markedly higher level than surrounding normal tissue. PHD3 is one of the target genes, of which the expressions are induced by HIFs. Because high level of HIF activities is known to play a crucial role in tumorigenesis of RCC, the control of PHD3 by HIFs is simply expected to be negative feedback loop. However, PHD3 shows strong tumorigenic effects in RCC by itself. The forced expression of PHD3 in Caki-1, where PDH3 is expressed at low level, stimulated the proliferation and led to tumor formation in xenografted nude mice. The knocking-down of PHD3 in A498 and 768-O RCC cell lines, where PHD3 is highly expressed, severely inhibited the cell-cycle progression and the proliferation. A498 tumors formed in xenografted nude mice were effectively shrinked by injection of lentivirus expression shRNA for PHD3. When the conditional expression system of shRNA for PHD3 was introduced to A498 cells, the xenografted tumors were completed disappeared by administration of doxycycline. The expression of p57KIP2 is characteristically reduced in RCC tissues. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1299. doi:1538-7445.AM2012-1299
TBCRC 012: ABCDE, a phase II randomized study of adjuvant bevacizumab, metronomic chemotherapy (CM), diet and exercise after preoperative chemotherapy for breast cancer.
Authors: E. L. Mayer, J. A. Ligibel, H. J. Burstein, K. Miller, L. A. Carey, H. S. Rugo, N. Ryabin, R. S. Gelman, E. P. Winer, A. C. Wolff
Journal: Journal of Clinical Oncology (2010)

TPS103
Scleredema: A Systemic Disease
Authors: Bert L. Vallee
Journal: New England Journal of Medicine (1946)

IN 1900, Buschke1 described the case of a forty-six-year-old carriage painter who suffered from persistent brawny induration of the skin of the face, chest and upper extremities. Following influenza, firm, nonpitting edema started in the neck and spread centrifugally. There was marked chemosis. The patient did not appear ill, had lost no weight, had no fever and had no complaints other than immobility of the skin. Buschke thought this picture to be distinct from those of previously reported syndromes and called the disease "scleredema adultorum."Many papers have since appeared in Germany delineating and expanding the original concepts,2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 and a . . .
SAT0054 The Body Mass Index and Its Influence on the Activity of Rheumatoid Arthritis: Results from the QUEST-RA Study Morocco.
Authors: M. Ezzahri, B. Amine, N. Hajjaj-Hassouni, B. Benchakroun, L. Benbrahim, S. Ahid
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The results of the international QUEST RA study showed that the high BMI was associated with a high activity of rheumatoid arthritis (RA) in women. Althoughour country is in developing, 25,2 % of the population is in overweight and 10,3% are obeses. <h3>Objectives</h3> The aim of our study was to analyze the relationship between body mass index (BMI) and the activity of rheumatoid arthritis in Moroccan population. <h3>Methods</h3> This is a multicenter cross-sectional study, conducted between December 2008 and May 2010, involving patients with rheumatoid arthritis in the QUEST-RA program of Morocco. The clinical and demographic data were collected by rheumatologists in the public and liberal sectors. The disease activity was assessed by clinical examination, ESR, CRP and DAS28. The functional impact was evaluated by the HAQ. BMI was stratified according to the Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults established in 1998, as follows: underweight &lt;18.5, normal weight: 18.5 to 24.9, overweight: 25 to 29.9 and obesity&gt; or = 30. <h3>Results</h3> 1129 patients were included, the mean age was 48.82 ± 12.71 years. Among our patients, 441 (42%) were overweight, 389 (37%) were normal weight, 186 (17.7%) were obese, and 35 (3.3%) in a state of underweight. The mean DAS28 was 4.93 ± 1.68. The mean score for DAS28 decreased with BMI; underweight (5.76 ± 1.41), normal (5.02 ± 1.75) in overweight (4.89 ± 1.58) and obesity (4.82 ± 1.58) in women, whereas the opposite trend was observed in men. The analysis of variance (ANOVA) did not detect a statistically significant relationship between the different categories of BMI and DAS28; underweight (ANOVA: p = 0.13), normal (p = 0.48), overweight (p = 0.29), obesity (p = 0.24). <h3>Conclusions</h3> The body mass index with its differents categories does not seem to be related to disease activity assessed by the DAS28 in Moroccan patients with RA, contrary to whatwas found onthe international QUEST-RA study. <h3>Disclosure of Interest</h3> None Declared
Union Launches Breast Cancer Outreach Program
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Union Launches Breast Cancer Outreach Program Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Page 756, https://doi.org/10.1093/jnci/83.11.756-a Published: 05 June 1991
P253 Isoniazid and Multi-Drug Resistant Mycobacterium Tuberculosis: The East London Experience
Authors: H Liddicoat, S Mohd-Afzal, J Potter, V White, N Jayasekera, M Darmalingam, H Kunst
Journal: Thorax (2015)

<h3>Introduction</h3> East London has one of the UK’s largest cohorts of Drug Resistant Tuberculosis (DR-TB). This paper aims to provide insight into the recent behaviour of DR-TB in a multi-ethnic urban TB clinic. <h3>Methods</h3> A retrospective study was conducted on all patients with DR-TB between 2007 and 2013. Statistical analysis was performed using Fisher’s Exact Test. <h3>Results</h3> 179 cases were identified: 126 patients had Isoniazid mono-resistance (H-Mono), 3 had poly-resistance including Isoniazid, and 37 patients had multi-drug resistant TB (MDR-TB). There were 6 cases of Rifampicin mono-resistance, 1 Ethambutol mono-resistance, and 6 Pyrazinamide mono-resistance. H-Mono and MDR-TB were more prevalent in males (58% and 57% respectively). H-Mono predominated in younger age groups (mode age group 25–29) whilst MDR-TB had a more uniform age distribution (Figure 1). The ethnicities of patients with DR-TB reflected the local population (Indian Subcontinent: 57% of H-Mono and 52% MDR-TB; Africa: 16% for both; Caucasian: 11% and 16% respectively; Other: 16% for both). The majority were non-UK born, however a meaningful proportion were UK-born (H-Mono 17% and MDR-TB 14%). Patients from all WHO world regions with DR-TB were more likely to have H-Mono, apart from Eastern Europe, where MDR-TB was more common (p = 0.005). The proportion of patients with pulmonary TB was similar in both cohorts (54% H-Mono and 65% MDR-TB, p = 0.26), as was the proportion of patients who were sputum smear-positive (46% and 38% respectively, p = 0.64). More patients with MDR-TB had a history of previous TB diagnosis compared to patients with H-Mono (p = 0.0005). Of note, the 5 UK-born patients with MDR-TB were all under the age of 40 with no specific risk factors or previous TB treatment. The number of TB notifications fell during this period, however the proportion of patients with MDR-TB remained stable at approximately 1%. In contrast, cases with any drug resistance reduced. <h3>Conclusion</h3> H-mono and MDR-TB shared many demographical features, but in this cohort there were significant differences in age distribution, previous diagnosis of TB and country of origin. A significant proportion of patients did not match the typical profile of DR-TB, highlighting the importance of culture to exclude drug-resistance in all individuals.
A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy
Authors: Samuel Wiebe, Warren T. Blume, John P. Girvin, Michael Eliasziw
Journal: New England Journal of Medicine (2001)

Randomized trials of surgery for epilepsy have not been conducted, because of the difficulties involved in designing and implementing feasible studies. The lack of data supporting the therapeutic usefulness of surgery precludes making strong recommendations for patients with epilepsy. We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for temporal-lobe epilepsy.
P77 Creation and Evaluation of a 2D/3D Molecular Database for Drugs Used to Target the Respiratory System
Authors: SJ Cassar, C Shoemake, LM Azzopardi
Journal: Thorax (2013)

<h3>Background</h3> Healthcare students and professionals could benefit greatly from using a holistic drug database as a reference point for clinical, physiochemical and structural information.<sup>1</sup> The involvement of certain drug therapy in the management of a condition can be facilitated by using 2dimensional and 3dimensional renditions.<sup>2</sup> <h3>Objectives</h3> To compile an electronic molecular database of drugs used in respiratory conditions to include constructions in two and three dimension, representations of drug protein interactions and to assess its utility by carrying out a randomised control study on a pharmacy student cohort. <h3>Design</h3> A repository of drugs pertaining to ‘respiratory system’ section of the BNF 64 was created to include structural information using molecular modelling software ex. Symyx<sup>®</sup>, VMD<sup>®</sup> and Sybyl<sup>®</sup>, clinical and physiochemical information. The database was compiled and uploaded onto the University’s website. A randomised control study using validated questionnaires was carried out on students reading for a degree in Bachelor of Science in Pharmaceutical Science. Their performance was assessed at baseline, after two weeks from using the database and four weeks after. Statistical results were generated using SPSS<sup>®</sup> 17. <h3>Results</h3> A total of, 46 2D structures and interactive 3D formats, and 21interactive representations of the 7PDB entries identified were created. A positive trend in student knowledge on drugs used in respiratory conditions was identified both immediately (post)and after a period of time (delayed), with students performing better after being exposed to the database during the intervention lecture as can be seen in Table 1. A significant improvement in the final marks was attained in the experimental group with respect to the control group for the first, second, third and fourth year undergraduate pharmacy students. <h3>Conclusions</h3> Student understanding and knowledge is enhanced when teaching practices take on an innovative approach. In fact, 86% of the students deemed the electronic database to be a relevant reference point of information during the undergraduate course.