tbuckley/cabot-search huggingface dataset:
THU0507 Self-Reported Pain 6 Months After Onset of Juvenile Idiopathic Arthritis is Related to Pain Score and Disease Outcome After 8 Years
Authors: E.D. Arnstad, E. Nordal, L. Berntson, K. Aalto, A. Fasth, T. Herlin, S. Nielsen, M. Zak, P.R. Romundstad, M. Rygg
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile Idiopathic Arthritis (JIA) is the most common rheumatic disease of childhood. Pain is a frequent complaint and an important reason for reduced quality of life for these children and adolescents. Knowledge of pain and its relevance for quality of life and disease outcome is limited. <h3>Objectives</h3> To study self-reported pain early in the disease course as predictor of persistent pain and disease outcome in a long-term perspective. <h3>Methods</h3> Consecutive cases of JIA with disease onset in 1997 to 2000 from defined geographical areas of Sweden, Denmark, Finland and Norway were prospectively included in a population-based cohort study (1). Self-reported pain was measured on a 10 cm visual analogue scale (VAS<sub>pain</sub>). Remission at 8-year follow-up was defined according to the preliminary criteria described by Wallace (2). Finnish participants did not fill in the pain score and were excluded. The final study population consisted of 302 children, 204 of these had filled in the pain score both 6 months after disease onset and at 8-year follow-up. For multivariable analyses we used binomial regression in STATA. <h3>Results</h3> Among the 204 children, 69% were girls, median onset age was 5.9 years and 50% had oligoarticular disease 6 months after onset. Six months after disease onset 74% reported VAS<sub>pain</sub> &gt;0. At 8-year follow-up 57% reported VAS<sub>pain</sub> &gt;0, and 61% was either not in remission or in remission on medication. We found an association between early pain reports and outcome 8 years later. For participants reporting no pain at 6 months, the risk of reporting pain at 8-year follow-up was 28% and the risk of not being in remission or in remission on medication was 27%. On the contrary, for participants reporting VAS<sub>pain</sub> &gt;0 at 6 months, the risk of reporting pain at 8 year was 68% and the risk of not being in remission or in remission on medication was 73%. The results were similar after adjustments for age and sex. <h3>Conclusions</h3> Early pain report appears to be predictive of both more severe disease outcome and more persistent pain in a long-term perspective. <h3>References</h3> Nordal E, et al. Arthritis Rheum 2011;63:2809-18 Wallace CA, et al. J Rheumatol 2004;31:2290-4 <h3>Disclosure of Interest</h3> None declared
Bone Localization of the Tetracyclines
Authors: Milch, Robert A., Rall, David P., Tobie, John E.
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Bone Localization of the Tetracyclines Get access Robert A. Milch, Robert A. Milch National Cancer Institute6 and National Institute of Allergy and Infectious Diseases,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar David P. Rall, David P. Rall National Cancer Institute6 and National Institute of Allergy and Infectious Diseases,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar John E. Tobie John E. Tobie National Cancer Institute6 and National Institute of Allergy and Infectious Diseases,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 1, July 1957, Pages 87–93, https://doi.org/10.1093/jnci/19.1.87 Published: 01 July 1957 Article history Received: 02 April 1957 Published: 01 July 1957
FRI0319 Value of Goal Directed Urate Lowering Therapy in Slowing the Progression of Renal Disease in Hyperuricemic Patients with Chronic Kidney Disease
Authors: K. Lee, S.-T. Choi, Y.-J. Ha, J.-S. Song
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Although uric acid has been known to exert a role in the progression of chronic kidney disease (CKD), only a few studies evaluated the renoprotective role of urate lowering therapy (ULT) in patients with hyperuricemia and CKD <h3>Objectives</h3> To determine whether ULT could delay the renal disease progression in hyperuricemic patients with CKD <h3>Methods</h3> We performed a retrospective review of hyperuricemic patients with stage 3 CKD followed from September 2005 to July 2014 in Dongguk University Ilsan Hospital, Goyang, Korea. A total of 158 eligible patients were identified and 65 of them were treated with ULT in addition to usual CKD management. We divided the patients according to the use of ULT and compared the estimated glomerular filtration rate (eGFR) change from baseline value and the proportion of renal disease progression (decline of eGFR greater than 30% of the baseline value, initiation of dialysis or eGFR &lt;15 mL/min/1.73m<sup>2</sup>) at the time of last follow-up. Risk factors for renal disease progression were identified by logistic regression analysis. <h3>Results</h3> After 1050±759 days of follow-up, the ULT group showed better outcomes compared to non-ULT group in terms of eGFR change from baseline (-1.19±12.07 vs. -7.37±11.17 mL/min/1.73m<sup>2</sup>, p=0.001) and the proportion of renal disease progression (12.3% vs. 27.9%, p=0.019). Goal directed ULT showed better clinical outcomes compared to maintaining the initial ULT dose. Mean serum uric acid was significantly associated with the risk of renal disease progression (<i>P</i> for trend=0.04) and mean serum uric acid level &lt;7 mg/dL reduced the risk of renal disease progression by 69.4%. <h3>Conclusions</h3> ULT significantly delayed the renal disease progression in hyperuricemic patients with CKD. Goal-directed ULT seems to be better than continuing the initial ULT prescription. <h3>Disclosure of Interest</h3> None declared
Deliberate releases of biological agents: initial lessons for Europe from events in the United States
Authors: R Harling, B Twisselmann, N Asgari, D Morgan, N Lightfoot, M Reacher, A Nicoll
Journal: Eurosurveillance (2001)

The experience of autumn 2001, when anthrax spores were released in the postal system, had considerable consequences in the United States and in Europe. The threat of covert deliberate releases against civilians has become a reality. In Europe, despite the growing number of criminal hoaxes, no cases of anthrax linked to deliberate releases have been reported, and the only contaminated letters were addressed to American embassies abroad. Nevertheless, the time has come for Europe to set up efficient and timely plans to respond to bioterrorism, under the coordination of the European Commission.
Clinical genetics, IV. Alzheimer's disease: from gene to pathology
Authors: G Jay
Journal: American Journal of Psychiatry (1997)

A defining histopathological feature in the brain of subjects with Alzheimer's disease is the presence of diffuse and neuritic plaques; their principal component is the β-amyloid peptide.Humans who genetically "overproduce" β-amyloid protein are prone to develop Alzheimer's disease.Yet, a firm demonstration that β-amyloid overproduction can produce the brain pathology of Alzheimer's disease has only recently appeared.A transgenic mouse has been developed by using a neuron-specific transcriptional promoter to direct expression of the murine β-amyloid coding sequence such that the β-amyloid peptide accumulates intraneuronally in the transgenic animal.Despite transgene expression in neurons throughout the brain, intracellular accumulation of β-amyloid was detected selectively in regions of the hippocampus (left figure, part b) and cerebral cortex (left figure, part e) of the animals, areas that are known to be particularly involved in the pathology of Alzheimer's disease.Hematoxylin and eosin staining revealed that neurons with intracellular accumulation of β-amyloid have an altered morphology (left figure, parts a and d) and appeared highly degenerative.The eventual death of these cells was by apoptosis (left figure, parts c and f), as revealed by DNA fragmentation determined by TUNEL staining.Moreover, gliosis in the same areas was prominent (right figure, part b) when compared to control litter mates (right figure, part a).Premature death in these animals increased linearly over the first months of life to a mortality of about 50% at 12 months (normal 12-month mortality is about 5%).This study shows that increased expression of β-amyloid intracellularly in transgenic mice is sufficient to serially induce neurodegeneration, apoptosis, astrogliosis, and, ultimately, spongiosis and is accompanied by seizures and premature death in the mice.Subsequent studies done in human postmortem Alzheimer dementia brain tissue confirm an association between overproduction of β-amyloid, apoptosis, and cell death.This observation that β-amyloid induces neuronal cell death through the apoptotic pathway in vivo suggests therapeutic approaches for the amelioration of Alzheimer's disease.This transgenic mouse model offers several experimental approaches to research in pathophysiology and therapeutics relevant to Alzheimer's disease.
Infrequent occurrence of EEG abnormalities in panic disorder
Authors: M B Stein, T W Uhde
Journal: American Journal of Psychiatry (1989)

EEG abnormalities have been frequently reported in patients with panic disorder, although controlled studies are lacking. The authors examined the EEGs of 35 consecutively evaluated, medication-free patients with panic disorder and found that only five (14%) had nonspecific abnormal EEGs and none displayed EEG evidence supportive of an ictal process. The presence or absence of EEG abnormalities was not significantly associated with the presence or absence of psychosensory symptoms. Although it is not likely that panic disorder is an epileptiform disorder, temporal lobe and limbic structures probably play a major role in the pathophysiology of panic.
THU0077 MIR-155 Facilitate the Differentiation of Th17 Cells by Inhibiting the Gene Expression of Ets-1
Authors: Z. Ye, Z. Yin, H. Zeng, W. He
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> MiR-155, an essential molecule in normal immune function, which is known to be a central regulator in the immune system, plays an important role in the development and differentiation of Th17 in recent studies. Ets-1 is a significant negative regulative factor of IL-17 generated by Th17 subset. Bioinformatics analysis and experiments as well verify that Ets-1 is also the target gene of miR-155. <h3>Objectives</h3> To elucidate the function way of miR-155 in the differentiation of Th17 cells. <h3>Methods</h3> CD4+T cells were separated from mice spleens and cultured with interleukins which can induce CD4+T cells differentiate into Th17 cells. IL-17 was detected by flow cytometry and ELISA after transfected with miR-155 mimics or inhibitor lentviral vectors. The expression levels of miR-155, IL-17A mRNA and Ets-1 mRNA were detected using quantitative reverse transcription PCR (qRT-PCR). The effect of si-Ets and miR-155 co-function for Th17 differentiation was analyzed. <h3>Results</h3> The CD4+T cells were divided into four groups (control untreat group, control treat group, miR-155 minics group and miR-155 inhibitor group). IL-17 was scarcely expressed and secreted in the control untreat group. IL-17 was expressed and secreted higher in the miR-155 minics group than that in the miR-155 inhibitor group and in the control treat group<i>(P</i>&lt;0.01). The expression of miR-155 and IL-17A mRNA was significantly higher than that in the other three groups<i>(P</i>&lt;0.05),while the expression of Ets-1 mRNA was significantly lower <i>(P</i>&lt;0.05). si-Ets-2# was screened because it markedly inhibited the expression of Ets-1 mRNA among the three designed siRNAs. The expression of IL-17A mRNA was higher and the expression of Ets-1 mRNA was lower in si-Ets-2# group than that in si-Con group when si-Ets-2# or si-Con was co-transfected with miR-155 mimics or inhibitor lentiviral vectors. The expression of Ets-1 protein was lower in si-Ets-2# group than that in si-Con group by Western blot and the decrease was markedly obvious in the miR-155 minics group. <h3>Conclusions</h3> miR-155 can induce CD4+T cells differentiate into Th17 cells by inhibiting the gene expression of Ets-1. <h3>Disclosure of Interest</h3> None declared
THU0118 General Applicability of a New Treat-to-Target Treatment Strategy in Dutch Patients with Early Rheumatoid Arthritis: Results from the Dream Remission induction Cohort II
Authors: L.M.M. Steunebrink, H.E. Vonkeman, P.M. Ten Klooster, H.H. Kuper, A.E. van der Bijl, P.L. van Riel, M.A. van de Laar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> New treatment options and strategies have dramatically reduced the severity and impact of rheumatoid arthritis (RA) and especially early intensive combination therapy, aimed at achieving remission, has shown good clinical outcomes. The reason for early identification and treatment of RA is to control progression of the disease. Since there is no cure for RA, the current most important goal is to reach remission as soon as possible, which should be sustained during the course of the disease. <h3>Objectives</h3> Despite wide implementation of treat-to-target (T2T) strategies in RA, a proportion of patients still fail to achieve early remission. This study aimed to identify baseline predictors of reaching remission in Dutch patients with early RA following a T2T strategy. <h3>Methods</h3> Baseline demographic, clinical and patient-reported outcome measures and one-year follow-up data were used from patients with early RA included in the DREAM remission induction cohort II study. Survival analyses and simple and multivariable logistic regression analyses were used to examine remission rates and significant predictors of achieving remission. <h3>Results</h3> A total number of 137 patients was included. 77.2% of the patients reached remission at least once in 12 months follow-up, and median time to first remission was 17 weeks. None of the examined baseline variables were significantly associated with achieving remission within 1 year. Lower ESR (p=0.007), male gender (p=0.057), better physical health status (p=0.062) and fewer tender joints (p=0.175) were significantly or marginally associated with achieving remission within 17 weeks. In multivariable analysis, however, only ESR remained significantly predictive (p=0.023). <h3>Conclusions</h3> The results indicate that baseline characteristics were not predictive of early remission. Together with the high proportion of responders, this provides additional evidence for the general applicability of T2T strategies in patients with early RA. <h3>Disclosure of Interest</h3> None declared
LZ Complexity Distance of DNA Sequences and Its Application in Phylogenetic Tree Reconstruction
Authors: Bin Li, Yi-Bing Li, Hong-Bo He
Journal: Genomics Proteomics & Bioinformatics (2005)

Abstract DNA sequences can be treated as finite-length symbol strings over a four-letter alphabet (A, C, T, G). As a universal and computable complexity measure, LZ complexity is valid to describe the complexity of DNA sequences. In this study, a concept of conditional LZ complexity between two sequences is proposed according to the principle of LZ complexity measure. An LZ complexity distance metric between two nonnull sequences is defined by utilizing conditional LZ complexity. Based on LZ complexity distance, a phylogenetic tree of 26 species of placental mammals (Eutheria) with three outgroup species was reconstructed from their complete mitochondrial genomes. On the debate that which two of the three main groups of placental mammals, namely Primates, Ferungulates, and Rodents, are more closely related, the phylogenetic tree reconstructed based on LZ complexity distance supports the suggestion that Primates and Ferungulates are more closely related.
Cortisol level response to 1- and 2-mg doses of dexamethasone
Authors: W A Brown, M Daamen, C D'Agostino, E L Dockery, P A Fournier, A H Parsells
Journal: American Journal of Psychiatry (1983)

Sixteen depressed patients underwent 1- and 2-mg overnight dexamethasone suppression tests in balanced order. Serum cortisol concentrations at all time points were significantly higher after the 1-mg dose. Nine patients were nonsuppressors after the 1-mg dose, and 4 after the 2-mg dose.
Platelet monoamine oxidase activity in schizophrenic patients
Authors: R E Becker, E G Shaskan
Journal: American Journal of Psychiatry (1977)

The authors studied platelet monoamine oxidase (MAO) activity in 29 schizophrenic inpatients and 26 schizophrenic outpatients during a 4-week double-blind trial of chlorpromazine with imipramine or thiothixene with placebo. The found that significantly more schizophrenic patients than normal control subjects had low platelet MAO activity after 4 weeks. Outpatients with low MAO activity were distinguished by increased behavioral activity and reduced social apathy. Inpatients with low MAO activity were distinguished by severity of illness and symptoms. Hallucinations were significantly more frequent among patients with low MAO activity. The authors suggest that platelet MAO activity might decline in some actively schizophrenic patients as part of the psychotic process.
Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis
Authors: William N Whiteley, Jonathan Emberson, Kennedy R Lees, Lisa Blackwell, Gregory Albers, Erich Bluhmki, Thomas Brott, Geoff Cohen, Stephen Davis, Geoffrey Donnan, James Grotta, George Howard, Markku Kaste, Masatoshi Koga, Rüdiger von Kummer, Maarten G Lansberg, Richard I Lindley, Patrick Lyden, Jean Marc Olivot, Mark Parsons, Danilo Toni, Kazunori Toyoda, Nils Wahlgren, Joanna Wardlaw, Gregory J del Zoppo, Peter Sandercock, Werner Hacke, Colin Baigent
Journal: The Lancet Neurology (2016)
Athletic groin pain: a systematic review of surgical diagnoses, investigations and treatment
Authors: Darren de SA, Per Hölmich, Mark Phillips, Sebastian Heaven, Nicole Simunovic, Marc J Philippon, Olufemi R Ayeni
Journal: British Journal of Sports Medicine (2016)

Athletic groin pain requiring surgery remains a diagnostic and therapeutic challenge. This systematic review aims to identify the most common causes of groin pain in athletes requiring surgery. Additionally, it aims to further characterise their susceptible athlete profiles, common physical examination and imaging techniques, and surgical procedures performed. This will enable the orthopaedic sports medicine clinician/surgeon to best treat these patients.The electronic databases MEDLINE, PubMed and EMBASE were searched from database inception to 13 August 2014 for studies in the English language that addressed athletic groin pain necessitating surgery. The search was updated on 4 August 2015 to find any articles published after the original search. The studies were systematically screened and data were abstracted in duplicate, with descriptive data presented.A total of 73 articles were included within our study, with data from 4655 patients abstracted. Overall, intra-articular and extra-articular causes of groin pain in athletes requiring surgery were equal. The top five causes for pain were: femoroacetabular impingement (FAI) (32%), athletic pubalgia (24%), adductor-related pathology (12%), inguinal pathology (10%) and labral pathology (5%), with 35% of this labral pathology specifically attributed to FAI.Given the complex anatomy, equal intra-articular and extra-articular contribution, and potential for overlap of clinical entities causing groin pain leading to surgery in athletes, further studies are required to ascertain the finer details regarding specific exam manoeuvres, imaging views and surgical outcomes to best treat this patient population.
SAT0242 Carotid Artery Ultrasound in Spondyloarthritis. Atherosclerosis Predicition with a New Risk Scoring System
Authors: E. Alonso Blanco-Morales, J. Bravo-Ferrer, R. Rey, C. Bejerano, C. Fernández, N. Oreiro, F. De Toro, F. Blanco, J. Pinto
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Carotid artery ultrasound (US) is a useful tool to asses subclinical atheromatosis. An increased intima-media thickness (IMT) has been described in patients with Spondiloartritis (SpA), mainly in ankylosing spondylitis (AS) and psoriatic arthritis (PsA). <h3>Objectives</h3> To evaluate subclinical atheromatosis in patients with SpA identifying associated risk factors and to design a scoring system that allow us to detect patients with increased risk of developing subclinical atheromatosis. <h3>Methods</h3> Observational and cross-sectional study of 100 SpA patients, randomly selected from their follow-up visit (2012-14). Demographic, clinical and laboratory data were collected. IMT was measured in mm with a Kotron Agile probe.IMT &gt;0.9mm or visualization of atheroma plaque was considered positive US (US+). SPSS v21.0 was used for statistical analysis, considering p&lt;0.05 as statistically significant. <h3>Results</h3> A total of 100 patients (59 APs and 41 AS) were included, mean age of 47 years (±13); 61% were men. Mean IMT was 0.64mm (±0.16). Eight patients had a GIM &gt;0.9mm and 11 patients had atheroma plaques. A total of 18 patients had US+. Variables associated with increased IMT and US+ are described in table 1. In the multivariate analysis US+ was associated with elevated serum levels of C-reactive protein, increased waist circumference, increased systolic blood pressure and age &gt;60 years. We design AROSpA (Age, Reactive C-protein, central Obesity, Sex, Systolic pressure, Score in SpA) risk score system based on these results. Cut-off points were chosen according to clinical established criteria and optimal likehood ratios in significant COR curve analysis. One point was assigned to each of the following items: Age &gt;60 years, C-reactive protein &gt;1mg/dL, waist circumference &gt;102/88cms (men/women), men sex gender, systolic blood pressure &gt;130 mmHg, and SCORE risk &gt;2%. In the COR curve analysis, AROSpA &gt;4 predicted US+ (sensitivity 100%, specifity 86%, positive likehood ratio (LH+) of 7.1; with an area under the curve (AUC) of 0.899, CI 95% 0.827-0.971, p&lt;0.001). <h3>Conclusions</h3> US+ was described in 18% SpA patients and it was associated with increased levels of CRP, waist circumference, blood pressure, age and risk in SCORE chart. AROSpA seems to be a simple, cheap and easy scoring system tool that would allow us to identify patients in whom carotid US should be performed to screening subclinical atherosclerosis with high sensitivity and specificity. These results should be validated in a prospective well-designed study, which we are currently underway. <h3>Disclosure of Interest</h3> None declared