tbuckley/cabot-search huggingface dataset:
Abstract 1574: The Hippo pathway regulates liver development and tumorigenesis in zebrafish.
Authors: Andrew G. Cox, Sebastian Beltz, Kimberley Evason, Didier Y. Stainier, Trista E. North, Wolfram Goessling
Journal: Cancer Research (2013)

Abstract The Hippo pathway is a novel signaling cascade that regulates cell proliferation, organ size and tumorigenesis in mammals. In mice, deregulation of the Hippo pathway in the liver has been shown to potently induce tumor formation. However, the molecular mechanism by which the Hippo pathway regulates hepatic growth is not well understood. In this study, we have examined liver development in NF2-/- mutant zebrafish, which exhibit systemic activation of Yap, and found that liver size was increased by 5 days post fertilization (dpf). Histological evaluation of the NF2-/- mutant zebrafish embryos revealed that the enlarged liver was composed of an extended biliary network. In order to examine the cell-autonomous effects of Yap activation in hepatocytes, we generated Tg(fabp10a:YapS87A) fish and found that liver size increased dramatically by 5 dpf. In contrast to the NF2-/- mutant, histological and FACS analysis revealed that the enlarged liver in the Tg(fabp10a:YapS87A) embryos was composed of a greater number of hepatocytes. Chemical exposure to the γ-secretase inhibitor DAPT or erlotinib rescued the hepatomegaly phenotype in 5 dpf Tg(fabp10a:YapS87A) embryos, indicating dependence on Notch and EGFR signaling pathways. To gain greater insight into how these developmental studies relate to tumorigenesis, we compared NF2+/- mutants and Tg(fabp10a:YapS87A) adults and found that both lines were predisposed to liver tumor formation, developing predominantly intrahepatic cholangiocarcinomas. Together, these studies reveal an evolutionarily conserved role of the Hippo pathway at the interface between liver development and tumorigenesis in zebrafish. Citation Format: Andrew G. Cox, Sebastian Beltz, Kimberley Evason, Didier Y. Stainier, Trista E. North, Wolfram Goessling. The Hippo pathway regulates liver development and tumorigenesis in zebrafish. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1574. doi:10.1158/1538-7445.AM2013-1574
Abstract 2415: Evaluation of a DNA vaccine and adjuvant construct for producing anti tumor immunity targeting IGFBP2
Authors: Gregory E. Holt, Ekram Gad, Yushe Dang, Mary Disis
Journal: Cancer Research (2010)

Abstract DNA based vaccines offer the advantage of stability, low cost, and longer duration of antigen exposure than protein based vaccines. We sought to evaluate strategies to augment the anti tumor potency. Using three immunogenic peptides from the ovarian cancer antigen, human insulin-like growth factor binding protein-2 (IGFBP2) we created a DNA epitope construct that encodes these three peptides in sequence and vaccinated mice with the epitope vaccine or an admixture of the peptides or plasmids expressing either the full length human or mouse genes. Mice received three vaccinations separated by two weeks followed fourteen days later by a lethal injection of syngeneic MMC tumor cells known to express IGFBP2. The DNA epitope vaccine produced a greater level of protection than any of the other constructs proving it to be the best formulation for inducing protective anti tumor responses. Full length human and mouse IGFBP2 DNA constructs induced a similar level of protection as the peptide based vaccine. This IGFBP2 epitope DNA vaccine was then tested in conjunction with plasmids encoding murine GM-CSF and IL-12 either alone or in combination in an identical vaccination strategy. Each genetic adjuvant either alone or in combination improved the level of protection induced by the IGFBP2 DNA epitope vaccine though no difference in tumor protection was seen between adjuvants used either alone or together. Evaluation of the inoculation site revealed a persistence of CD11c+ dendritic cells and CD3+ T cells fourteen days after final vaccination predominantly in mice who received plasmids containing the cytokines versus those who received soluble protein. These data support the use of epitope based DNA vaccines in conjunction with genetic adjuvants for the production of anti tumor efficacy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2415.
Photochemical Degradation of Chlorobiphenyls (PCBs)
Authors: O. Hutzinger, S. Safe, V. Zitko
Journal: Environmental Health Perspectives (1972)

Polychlorinated biphenyls (PCBs) are stable towards oxidation, hydrolysis and other chemical reactions which conceivably occur in the environment. Although there is little direct evidence available, it is generally assumed that PCBs, particularly those with a high chlorine content, are also quite resistant to metabolic change. Over the past years photochemical degradation was shown to be a possible major route of environmental breakdown for a number of pesticides (1-4). Until relatively recently (5), however, simple chloroarornatic compounds have not received much attention. The limited interest of photochemists in compounds of this type can perhaps be explained by the commonly held view that there is generally little cleavage of the C-Cl bond in chloroaromatic compounds (6). We have previously shown (7) that 2,2',4,4', 6,6'-hexachlorobiphenyl, when irradiated at 3100 A in hexane, photolyzes rather readily to give products which are formed by loss of chlorine, rearrangement and condensation. We now wish to present a first report of our studies on the photochemical stability of a number of chlorobiphenyl isomers in hexane as well as on the breakdown of chlorobiphenyls under  and simulated natural conditions, with particular emphasis on polar products. Considerable experience in laboratory irradiations of pesticides has accumulated (1, 3, 8) and an elaborate weathering chamber, which also allows controlled irradiation, has been described
BALLOON PULMONARY ANGIOPLASTY IMPROVES RIGHT VENTRICULAR THE PARAMETER OF DIASTOLIC FUNCTION IN PATIENTS WITH INOPERABLE CHRONIC THROMBOEMBOLIC PULMONARY HYPERTENSION
Authors: Yukio Aikawa, Akihiro Tsuiji, Shigefumi Fukui, Jin Ueda, Takeshi Ogo, Yoshihiro Sanda, Yoshiaki Morita, Tetsuya Fukuda, Satoshi Yasuda, Hisao Ogawa, Norifumi Nakanishi
Journal: Journal of the American College of Cardiology (2015)
Tc-99m Albumin Scintigraphy in Protein-Losing Gastroenteropathy Caused by Gastric Polyposis
Authors: YUSUKE INOUE, TOHRU OHTAKE, HISAO KOGA, JUNICHI NISHIKAWA, KOHKI YOSHIKAWA, YASUHITO SASAKI
Journal: Clinical Nuclear Medicine (1998)

A 58-year-old man with gastric polyposis and hypoalbuminemia underwent abdominal imaging with Tc-99m human serum albumin (HSA). This study indicated protein-losing gastroenteropathy, and protein loss from gastric polyps was suspected. After total gastrectomy, hypoalbuminemia was improved, and follow-up Tc-99m HSA imaging confirmed remission of the disease.
Blood eosinophil count and exacerbations in severe chronic obstructive pulmonary disease after withdrawal of inhaled corticosteroids: a post-hoc analysis of the WISDOM trial
Authors: Henrik Watz, Kay Tetzlaff, Emiel F M Wouters, Anne Kirsten, Helgo Magnussen, Roberto Rodriguez-Roisin, Claus Vogelmeier, Leonardo M Fabbri, Pascal Chanez, Ronald Dahl, Bernd Disse, Helen Finnigan, Peter M A Calverley
Journal: The Lancet Respiratory Medicine (2016)
AB0017 Association study of genetic risk variants for psoriasis in a large cohort of psoriatic arthritis, psoriasis and controls of the spanish population and association with relevant clinical subphenotypes
Authors: J.D. Cañete, J.M. Hernanz, E. Fonseca, C. Ferrandiz, P. Unamuno, L. Puig, J.L. Fernandez-Sueiro, R. Sanmartí, J. Rodriguez, J. Gratacόs, E. Dauden, J.L. Sánchez-Carazo, J.L. Lόpez-Estebaranz, D. Moreno, R. Queirό, C. Ferrandiz, J.C. Torre-Alonso, J.J. Pérez-Venegas, F. Vanaclocha, E. Herrera, S. Muñoz-Fernández, C. González, D. Roig, A. Erra, I. Acosta, A. Fernandez-Nebro, P. Zarco, A. Alonso, M. Lόpez-Lasanta, A. Julià, R. Tortosa, S. Marsal
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> Psoriatic Arthritis (PsA) is a complex disease with a substantial genetic risk component (first-degree relative risk ∼55). Recently, Genomewide Association Studies (GWAS) have expanded the number of risk loci for Psoriasis (Ps) in &gt;20 new loci. <h3>Objectives</h3> We have studied the association of Ps risk loci in PsA and purely cutaneous Ps (PsC). We have also analyzed the genetic association with several subphenotypes of clinical relevance. <h3>Methods</h3> Loci showing the strongest statistical evidence of association to Ps were selected (n=32). The SNP having the highest statistical evidence was genotyped using Taqman technology in a cohort of n=955 PsA, 1,050 PsC and 1,497 hypernormal controls of the Spanish population. According to each subphenotype variable, the genetic association was performed using the chi-square test, logistic regression or linear regression. <h3>Results</h3> We have replicated the association to <i>COG6</i> and <i>SERPINB8</i> loci with Ps for the first time in a Caucasian population. We have identified, for the first time, an association of PsA with variation at <i>IFIH1</i>, <i>DPP6</i> and <i>COG6</i>. Analyzing the association with other clinically relevant subphenotypes we have identified a strong association of <i>LCE3D</i> locus with the severity of cutaneous affection. We have also found a significant association of <i>IL1RN</i> gene with nail disease. <h3>Conclusions</h3> Our findings show that common genetic variants associated to a complex phenotype like PsV influence PsA as well as different subphenotypes of high clinical relevance. <h3>Disclosure of Interest</h3> None Declared
Toll-like Receptor 4 Signaling Pathway Mediates Inhalant Organic Dust-Induced Bone Loss
Authors: Jill A. Poole, Elizabeth Klein, Anand Dusad, Todd Wyatt, Debra Romberger, Michael Duryee, Lynell Klassen, Ted Mikuls, Dong Wang, Geoffrey Thiele
Journal: Journal of Allergy and Clinical Immunology (2016)
Controversial allergy doctor admits faults in her treatment of a patient with lead poisoning
Authors: C. Dyer
Journal: BMJ (2012)

A doctor specialising in environmental medicine whose work has attracted controversy for decades is facing charges at the General Medical Council of giving a potentially harmful treatment based on inadequate evidence.

Jean Monro is accused of using an inappropriate test to diagnose lead poisoning, failing to inform a patient’s GP about possible complications of chelation therapy and going ahead with the treatment after learning that the GP had reported her to the regulator.

Dr Monro is medical director of the private Breakspear Hospital in Hemel Hempstead, Hertfordshire, which is described on the allergy information website foodsmatter.com as working “mainly with patients who have …
ALTERNATE PROTOCOL FOR PROSTASCINT IMAGING USING DUAL ISOTOPE SPECT ACQUISITION AND COMPUTER SUBTRACTION: PRELIMINARY RESULTS
Authors: B. Patel, M Friedman, T. O'Dowd, B. Rubas, K. Q. Lin, H. Levi, M. J. Blend
Journal: Clinical Nuclear Medicine (1997)

Scientific Abstracts: Central Chapter, Society Of Nuclear Medicine Meeting, April 11-13, 1997, Grand Geneva Resort, Lake Geneva, Wi
Abstract 2426: Role of fibroblast growth factor receptor 1 (FGFR1) in liver metastasis of colorectal cancer
Authors: Myung Eun Lee, Yoo Kun Shin, Hei-Cheul Jeung, Sang Joon Shin, Young Kyu Park, Xue-Feng Zhao, Tae Soo Kim, Joong- Bae Ahn, Hyun Cheol Chung, Sun Young Rha
Journal: Cancer Research (2012)

Abstract Liver metastasis is one of the main cause of death among patients with colorectal cancer (CRC). However, accurate prediction of liver metastasis of CRC is difficult at the inception of diagnosis. Activated receptor tyrosine kinases (RTKs) are the main mediators of the signaling pathway related to cell survival, proliferation, differentiation or apoptosis. To determine if any of these RTKs are involved in liver metastasis from CRC, we performed phospho-receptor tyrosine kinase array with matched 20 colon normal mucosa, primary tumor, metastatic liver tumor, and liver normal tissue proteins using Human Phospho-RTK Array (2009 AACR, #4951). In RTK activation profiling, FGFR1 activation was increased in a high proportion of metastatic liver tumor (p &amp;lt; 0.05). To evaluate the functional roles of FGFR1, DLD-1 and LoVo colon cancer cells were treated with FGFR1 specific siRNA or RTK inhibitor. Inhibition of FGFR1 inhibited phosphorylation of PI3K/AKT and ERK, a downstream cellular signaling molecule of FGFR; whereas, mTOR, p70S6K, JNK and Src activities were not affected. Also, we compared the cell migration and invasion ability by wound healing assay and invasion assay. The invasion capacity and wound closing were significantly delayed by FGFR1 inhibition (p &amp;lt;0.05). To evaluate in vivo anti-metastatic effect of FGFR1, we used an orthotropic liver metastasis model, generated by injecting LoVo colon cancer cells into spleen of BALB/c nu/nu mice. In control group, multiple large metastatic foci were evident, whereas the extent of liver metastasis was dramatically reduced in TKI-258 (50mg/kg/d) treated group (48.9%, p&amp;lt;0.05). Immunoexpression of the p-FGFR1 was much more intense in control than TKI-258 treated tumor tissues. Biological effects were also confirmed that FGFR1 inhibition resulted in a significant reduction of ERK activation and Ki-67 positive cells in tumor tissues. In conclusion, FGFR1 might be a good target for liver metastasis of CRC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2426. doi:1538-7445.AM2012-2426
The Avastin Story
Authors: Mikkael A. Sekeres
Journal: New England Journal of Medicine (2011)

To the Editor: Recently, the Food and Drug Administration (FDA) held an administrative hearing regarding the proposal to withdraw accelerated approval from Avastin (bevacizumab) for metastatic breast cancer. I served as a member of the Oncologic Drugs Advisory Committee (ODAC) at that meeting. Two recent online Perspective articles, by Carpenter et al.1 and D'Agostino,2 addressed the use of surrogate end points and the regulatory and political issues surrounding this hearing. But neither article covered a basic, patient-focused theme that we, the oncologists on the panel, considered: that of giving hope — but not false hope. Avastin received accelerated approval from . . .
Polyarthritis and Fever
Authors: Robert S. Pinals
Journal: New England Journal of Medicine (1994)

Perhaps no disease is more painful than acute polyarthritis. The inability to change the posture without agonizing pain, the drenching sweats, the prostration, utter helplessness, combine to make it one of the most distressing of febrile afflictions. A special feature of the disease is the tendency of the inflammation to subside in one joint, while developing with great intensity in another.-- Sir William Osler, The Principles, Practice of Medicine.Osler's vivid description of acute polyarthritis a century ago1 referred to rheumatic fever, clearly the bellwether of this group of disorders in that era. Despite its high worldwide prevalence in . . .
The Economic Impact of Multiple-Gestation Pregnancies and the Contribution of Assisted-Reproduction Techniques to Their Incidence
Authors: Tamara L. Callahan, Janet E. Hall, Susan L. Ettner, Cindy L. Christiansen, Michael F. Greene, William F. Crowley
Journal: New England Journal of Medicine (1994)

Although the medical complications associated with multiple-gestation pregnancies have been well documented, little is known about the effects of such pregnancies on the use of health care resources and the associated costs. This is an important issue because of the increasing use of assisted-reproduction techniques, which commonly result in multiple-gestation pregnancies.
Abstract 591: Expanding the therapeutic window through pharmacological activation of the RB pathway in breast cancer treatment
Authors: Kathleen McClendon, Jeffry L. Dean, Dayana Rivadeneira, Christopher A. Reed, Agnieszka Witkiewicz, Erhe Gao, Walter J. Koch, Thomas Force, Erik S. Knudsen
Journal: Cancer Research (2011)

Abstract Triple negative breast cancer (TNBC) is a highly aggressive disease that is most often treated with cytotoxic chemotherapies, such as anthracyclines and platinum compounds. While effective for certain tumors, these therapies are known to cause severe toxicities in numerous tissues. Thus, targeting pathways to both exploit therapy-sensitive tumors and ameliorate tissue toxicity is of utmost significance. Loss of the retinoblastoma tumor suppressor (RB) protein is a frequent event in TNBC, and is expected to alter therapeutic sensitivity by perturbing cell cycle checkpoints and yielding a predilection towards cell death. Conversely, it is possible that the same principles that drive sensitivity to cytotoxic agents in an RB-deficient setting could be used to prevent toxicities in an RB-proficient setting (i.e. normal tissues). Thus, modulation of the RB pathway could be critical for expanding the therapeutic window in the treatment of breast cancer. To address this hypothesis, combination studies of pharmacological activation of the RB pathway and cytotoxic chemotherapies commonly used to treat TNBC were performed in vitro and in vivo. Results indicate that activation of the RB pathway can modulate the efficacy of cytotoxic compounds in the treatment of TNBC. The mechanisms behind these observations were attributed directly to RB-mediated regulation of DNA damage and repair signaling pathways, as well as apoptosis. RB-deficiency resulted in bypass of these mechanisms and thus enhanced sensitivity to cytotoxic therapies. These results were supported by in silico data demonstrating that RB-deficient TNBC is associated with better clinical outcome in response to chemotherapy. Importantly, functional studies indicated that RB pathway activation can provide protection against the toxicity of frequently used chemotherapeutic compounds in normal tissue. Combined, these studies suggest that RB pathway status could be utilized in the clinic to direct combination treatments that would exploit the sensitivity of RB-deficient tumors to cytotoxic chemotherapies while simultaneously providing protection for normal tissues. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 591. doi:10.1158/1538-7445.AM2011-591
Abstract P5-14-12: Management of Phyllodes Breast Tumours: A Review of 165 Cases
Authors: E Guillot, B Couturaud, F Reyal, A Curnier, J Ravinet, M Laé, M Bollet, JY Pierga, R Salmon, A. Fitoussi
Journal: Cancer Research (2010)

Abstract Aim:The aim of our study was to examine the treatment and outcome of 165 patients with phyllodes tumours and to review the options for surgical management. Patients and Methods: This is a retrospective study of 165 patients who presented to the Institut Curie between January 1994 and November 2008 for benign, borderline or malignant phyllodes tumours. Results: The median follow-up was 12.65 months [range 0 to 149.8]. The median age at diagnosis was 44 years [range 17 to 79]. One hundred and sixty patients (97%) had breast conserving treatment, of whom 3 patients (1. 8%) had oncoplastic breast surgery. Younger women had a significantly higher chance of having a benign phyllodes tumor (p = 0.0001) or a tumour of small size (&amp;lt; 0.0001). Histological examination showed 114 benign (69%), 37 borderline (22%) and 14 malignant tumours (9%). The median tumour size was 30 mm [range 5 to 150]. The tumour margins were considered incomplete (&amp;lt; 10 mm) in 46 out of 165 cases (28%) with 52% revision surgery. Only the tumour grade was a significant risk factor for incomplete tumour margins (p = 0.005). Fifteen patients developed local recurrence (10%) and two, metastases. In univariate analysis, the histological grade (p = 0.008) and tumour size (p=0.02) were significative risk factors for local recurrence with an accentuated risk for borderline tumours and tumours of large size. Similar results were obtained using multivariate analysis (p=0.07) Conclusion: The mainstay of treatment for phyllodes tumours remains excision with a safe surgical margin, taking advantage breast conserving surgery where amenable. For borderline or malignant phyllodes tumours or in cases of local tumour recurrence, mastectomy and immediate breast reconstruction may become the preferred option.Genetic analysis will potentially supplement classical histological examination in order to improve our management of these tumours. The role of adjuvant treatments is unproven and must be considered on a case-by-case basis. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P5-14-12.
Man's Best Friend May Be Companion in Cancer Research
Authors: L. Seachrist
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Man's Best Friend May Be Companion in Cancer Research Get access Lisa Seachrist Lisa Seachrist Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 18, 15 September 1993, Pages 1455–1456, https://doi.org/10.1093/jnci/85.18.1455 Published: 15 September 1993
DEFINITE STENT THROMBOSIS: DOES HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL MATTER?
Authors: Pranav Kansara, Wasif Qureshi, Claudine Jurkovitz, James Hopkins, Usman Choudhry, James Laughery, Paul Kolm, Ehsanur Rahman, Sandra Weiss, William S. Weintraub
Journal: Journal of the American College of Cardiology (2015)
Abstract 4693: Maternal GSTP1 Ile105Val polymorphism and petrochemical exposure in relation to the childhood leukemia in southern Taiwan
Authors: Chen-yu Liu
Journal: Cancer Research (2010)

Abstract We conducted a population-based case-control study in an industrial city of southern Taiwan to investigate childhood leukemia risk in relation to the association of maternal and offspring polymorphisms with residential petrochemical exposures. A total of 109 leukemia cases and 220 controls younger than 20 years were recruited between November 1997 and December 2005. A procedure using geographic information system tools was used to estimate individual-level exposure by accounting for subjects’ mobility, length of stay at each residence, distance to petrochemical plant(s), and monthly prevailing wind direction. Multivariate logistic regression was used to assess the effects of petrochemical exposures, maternal and offspring's GSTP1 genotypes, and their joint roles on offspring's leukemia risk. No main effect of residential petrochemical exposure was observed, yet the exposure association was influenced by maternal GSTP1 genotypes alone as well as by the combined maternal and offspring genotypes (P for interaction=0.02 and 0.01, respectively). Among the subjects with both mothers and offspring carrying the GSTP1 105Val variant allele(s), the adjusted odds ratio was 1.34 (95 percent confidence interval: 1.02, 1.76) for each unit of increase in the log-transformed exposure opportunity score. In conclusion, this study suggests that the childhood leukemia risk is associated with the residential petrochemical exposures, modified by both offspring's and maternal GSTP1 genotypes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4693.