tbuckley/cabot-search huggingface dataset:
Hepatitis B Virus Reactivation In Surface Antigen-Negative Patients with B-Cell Non-Hodgkin's Lymphoma Treated with Rituximab
Authors: Liang-Tsai Hsiao, Po-Min Chen, Yu-Jiun Chan, Yi-Hsiang Huang, Yuan-Bin Yu, Chun-Yu Liu, Ying-Chung Hong, Sheng-Hsiang Yang, Jyh-Pyng Gau, Jin-Hwang Liu, Tzeon-Jye Chiou, Cheng-Hwai Tzeng
Journal: Blood (2010)
The Teaching of Preventive Medicine in Europe
Journal: JAMA (1934)

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Report of the Relapsed/Refractory Cohort of SWOG S0919: A Phase 2 Study of Idarubicin and Cytarabine in Combination with Pravastatin for Acute Myelogenous Leukemia
Authors: Anjali S. Advani, Hongli Li, Laura C. Michaelis, Bruno C. Medeiros, Michaela Liedtke, Alan F. List, Kristen O'Dwyer, Megan Othus, Harry P. Erba, Frederick R Appelbaum
Journal: Blood (2015)
Equivalent Survival Following Fludarabine/Melphalan Reduced Intensity Conditioning with or without Rabbit ATG As Part of GvHD Prophylaxis
Authors: J. Mark Prichard, Samatha Muppidi, Christopher R Flowers, Jonathan L. Kaufman, Mary Jo Lechowicz, Sagar Lonial, Ajay K. Nooka, Rajni Sinha, Edmund K Waller, Amelia Langston
Journal: Blood (2011)
A Study of the Hereditary Hyperferritinemia Cataract Syndrome in Patients of Greek Origin
Authors: Stamatia-Lydia Hatzinicolaou, Danai Palaiologou, Antonios G Antoniadis, Georgios Papanikolaou, Nikolaos Sakellaropoulos, Gerassimos A Pangalis, John Meletis, Antonios Kattamis
Journal: Blood (2012)
The Fanconi Anemia Protein, FANCG, Binds Directly to the SH3 Domain of aII Spectrin and This Interaction May Play An Important Role in the Stability of aII Spectrin and Its Function in Repair of DNA Interstrand Cross-Links
Authors: Joel A Lefferts, Chuan Wang, Melissa Baralt, Muriel W Lambert
Journal: Blood (2008)
Rituximab-Mediated Upregulation of PTEN Expression and Inhibition of Both the PI3K/AKT Pathway and Pleitrophin (PTN) Expression in B-NHL: Roles in Cell Growth Inhibition and Chemosensitization.
Authors: Eriko Suzuki, Haiming Chen, Stavroula Baritaki, Mario I. Vega, Melinda Gordon, Gary J. Schiller, James Berenson, Benjamin Bonavida
Journal: Blood (2006)
GATA1 Mutants Lacking Rb-Binding Motif Observed in Transient Abnormal Myelopoiesis in Down Syndrome
Authors: Tsutomu Toki, Eri Kobayashi, Rika Kanezaki, RuNan Wang, Kiminori Terui, Hirokazu Kanegane, Miho Maeda, Mikiya Endo, Tatsuki Mizuochi, Souichi Adachi, Yasuhide Hayashi, Ritsuko Shimizu, Masayuki Yamamoto, Etsuro Ito
Journal: Blood (2011)
Metronomic Chemotherapy Is Effective and Well Tolerated in Relapsed/Refractory Elderly Patients with Aggressive B- and T-Cell Lymphomas
Authors: Maria Christina Cox, Elena Cavalieri, maria Paola Bianchi, Raffaele Porrini, Virginia Naso, Marco di Girolamo, Daniela Prosperi, Francesca di Landro, Agostino Tafuri
Journal: Blood (2015)
HbF-Associated Genetic Variation Marks an Erythroid Regulatory Element Essential for BCL11A Transcription and Subsequent Stage-Specific Globin Expression
Authors: Daniel E. Bauer, Sophia C Kamran, Jian Xu, Carrie Lin, Zhen Shao, Yuko Fujiwara, Richard A. Voit, Matthew H. Porteus, John A. Stamatoyannopoulos, Stuart H. Orkin
Journal: Blood (2012)
P1266 : Human albumin use in cirrhotic patients in France: Results of the national “Albu-live” survey
Authors: A. Garioud, J.-F. Cadranel, A. Pauwels, T. Thévenot, A. Louvet, T. Dao, P. Sogni, N. Talbodec, C. Bureau, D. Thabut, L. Elkrief, V. Jouannaud, G. Macaigne, B. Bernard-Chabert, H. Lison, L. Alric, N. Carbonnel, G.-P. Pageaux, L. Bettan, H. Labadie, P. Nahon, R. Bader, J.-P. Zarski, A. Abergel, S. Pol, A. Pariente, X. Amiot, P. Mathurin, I. Ollivier-Hourmand, M. Bismuth, K. Dupont, I. Rosa-Hézode, B. Lesgourgues, V. Leroy, T. Poynard, X. Causse, O. Chazouillères, D. Valla, D. Zanditenas, C. Renou, J.-C. Trinchet, T. Paupard, D. Ouzan, D. Guyader, T. Fontanges, B. Hanslik, V. De Lédinghen, J. Denis
Journal: Journal of Hepatology (2015)
Oct-4 Is Crucial for Murine Embryonic Stem Cell Secretion of Cytokines/Growth Modulators That Enhance Cell Survival/Anti-Apoptosis of Murine ES Cells and Bone Marrow Hematopoietic Progenitor Cells.
Authors: Ying Guo, Barbara Graham-Evans, Charlie R. Mantal, Robert A. Hromas, Hal E. Broxmeyer
Journal: Blood (2005)
Obatoclax in Combination with Fludarabine and Rituximab (FR) Is Well-Tolerated and Shows Promising Clinical Activity in Relapsed CLL/SLL
Authors: Jennifer R Brown, Bethany Tesar, Lillian Werner, Evgeny Mikler, Hazel Reynolds, Christina Thompson, David C. Fisher, Naoko Takebe, Donna Neuberg, Arnold S. Freedman
Journal: Blood (2011)
Data and Safety Monitoring Board evaluation and management of a renal adverse event signal in <scp>TOPCAT</scp>
Authors: Michael R. Bristow, Kavita Sharma, Susan F. Assmann, Stuart Linas, Bernard J. Gersh, Christine Grady, Madeline Murguia Rice, Steven Singh, Robin Boineau, Sonja M. McKinlay, Barry H. Greenberg
Journal: European Journal of Heart Failure (2016)
Прогресування фіброзу печінки у хворих на стабільну ішемічну хворобу серця на тлі неалкогольної жирової хвороби печінки
Authors: I.I. Vakalyuk, N.G. Virstyuk, V.M. Kazmiruk
Journal: GASTROENTEROLOGY (2016)

Мета: оцінити жорсткість печінки у хворих на стабільну ішемічну хворобу серця (ІХС) на тлі неалкогольної жирової хвороби печінки (НАЖХП) залежно від вираженості коронарного атеросклерозу. Матеріали і методи. Обстежено 220 хворих на стабільну ІХС, поєднану з НАЖХП. Серед них були виділені пацієнти з неалкогольним жировим гепатозом (НАЖГ) та неалкогольним стеатогепатитом (НАСГ). Контрольну групу становили 20 практично здорових осіб. Усім хворим проведено загальноклінічне обстеження, електрокардіографію, коронарографію, еластографію, оцінку функціонального стану печінки. Результати. Аналіз отриманих результатів виявив підвищення жорсткості печінки в усіх групах хворих порівняно з контролем. Зокрема, у хворих із НАЖГ швидкість зсувної хвилі вірогідно перевищувала показник здорових осіб у всіх групах хворих. За умов НАСГ показник жорсткості паренхіми печінки більше ніж вдвічі перевищував рівень контрольної групи. Встановлено вірогідну відмінність стану паренхіми печінки залежно від стадії НАЖХП. Аналіз стадійності фібротичних змін печінки виявив певні закономірності залежно від прогресування НАЖХП. Зокрема, стадія F1 фіброзу печінки мала місце у більше ніж половини хворих групи ІА (р &lt; 0,05). У хворих групи ІБ на фоні НАСГ близько у 60 % осіб спостерігали стадію F2 фіброзу (р &lt; 0,05), а у 25 % пацієнтів — стадію F3. У хворих ІІ групи стадійність фіброзу суттєво не відрізнялась від пацієнтів І групи. Найбільш прогностично несприятливий перебіг НАЖХП виявлено у ІІІ групі. Зокрема, у 34,8 % осіб групи ІІІА спостерігали стадію F2 фіброзу, у випадку НАСГ у понад 70 % хворих групи ІІІБ виявляли значні фібротичні зміни паренхіми печінки стадії F3 (р &lt; 0,05). Більше того, понад 13 % пацієнтів групи ІІІБ мали стадію F4 фіброзу. Висновки. Перебіг НАЖХП у хворих на стабільну ІХС характеризується підвищенням жорсткості паренхіми печінки, що вірогідно залежить від стадії НАЖХП та є більш вираженою на тлі НАСГ. Прогресування фіброзу печінки у хворих із НАЖХП, що поєднана зі стабільною ІХС, залежить від вираженості коронарного атеросклерозу та є найбільш прогностично несприятливим у хворих із перенесеним гострим коронарним синдромом та вираженими рубцевими змінами міокарда.
Promoting Partner Testing and Couples Testing through Secondary Distribution of HIV Self-Tests: A Randomized Clinical Trial
Authors: Samuel H. Masters, Kawango Agot, Beatrice Obonyo, Sue Napierala Mavedzenge, Suzanne Maman, Harsha Thirumurthy
Journal: PLoS Medicine (2016)

Achieving higher rates of partner HIV testing and couples testing among pregnant and postpartum women in sub-Saharan Africa is essential for the success of combination HIV prevention, including the prevention of mother-to-child transmission. We aimed to determine whether providing multiple HIV self-tests to pregnant and postpartum women for secondary distribution is more effective at promoting partner testing and couples testing than conventional strategies based on invitations to clinic-based testing.We conducted a randomized trial in Kisumu, Kenya, between June 11, 2015, and January 15, 2016. Six hundred antenatal and postpartum women aged 18-39 y were randomized to an HIV self-testing (HIVST) group or a comparison group. Participants in the HIVST group were given two oral-fluid-based HIV test kits, instructed on how to use them, and encouraged to distribute a test kit to their male partner or use both kits for testing as a couple. Participants in the comparison group were given an invitation card for clinic-based HIV testing and encouraged to distribute the card to their male partner, a routine practice in many health clinics. The primary outcome was partner testing within 3 mo of enrollment. Among 570 participants analyzed, partner HIV testing was more likely in the HIVST group (90.8%, 258/284) than the comparison group (51.7%, 148/286; difference = 39.1%, 95% CI 32.4% to 45.8%, p < 0.001). Couples testing was also more likely in the HIVST group than the comparison group (75.4% versus 33.2%, difference = 42.1%, 95% CI 34.7% to 49.6%, p < 0.001). No participants reported intimate partner violence due to HIV testing. This study was limited by self-reported outcomes, a common limitation in many studies involving HIVST due to the private manner in which self-tests are meant to be used.Provision of multiple HIV self-tests to women seeking antenatal and postpartum care was successful in promoting partner testing and couples testing. This approach warrants further consideration as countries develop HIVST policies and seek new ways to increase awareness of HIV status among men and promote couples testing.ClinicalTrials.gov NCT02386215.
THU0534 Skipping Breakfast Increases Serum Uric Acid Levels
Authors: S. Liu, J.N. Miner
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Lifestyle intervention is an important component in uricemic control. Diets with low purine and fructose content, as well as limited alcohol consumption, are recommended for people with hyperuricemia/gout.<sup>1</sup> It has been reported that a 2-day fast can lead to higher serum uric acid (sUA) levels, with a concomitant decrease in urinary uric acid excretion.<sup>2</sup> This work explores whether a shorter fast, such as simply skipping breakfast, affects sUA levels. <h3>Objectives</h3> To study the effect on sUA of skipping breakfast. <h3>Methods</h3> Two successive experiments were conducted with the same group of healthy subjects (N=30). In the first experiment the subjects consumed all three meals during the day, whereas in the second experiment the subjects did not eat breakfast but had the other two meals as usual. sUA and fractional excretion of uric acid (FEUA) were measured throughout the 24 hr experiment period. In addition, corresponding sUA levels were simulated based on the measured FEUA in order to evaluate the contribution of FEUA to the effects of breakfast on measured sUA. <h3>Results</h3> At 6, 12 and 24 hr after breakfast (∼8 am), the mean±SE change from baseline (pre-breakfast) in sUA was -0.3±0.09, -0.4±0.1 and +0.1±0.09 mg/dL, respectively, when the group ate breakfast (Figure). These changes average to a decrease in sUA of 0.2±0.08 mg/dL over 24 hrs. In comparison, the change in sUA from baseline was +0.3±0.05, +0.1±0.09 and +0.3±0.07 mg/dL at 6, 12 and 24 hr when they did not eat breakfast. These changes average to an elevation in sUA of 0.2±0.05 mg/dL over 24 hrs. As a result, the difference in sUA (no breakfast - breakfast) was +0.4±0.09 mg/dL (p&lt;0.0001). In the first 6 hrs after breakfast, FEUA were 7.3±0.45 with breakfast and 5.7±0.33 without breakfast (Figure, p&lt;0.01). However, when sUA levels are simulated based on the observed FEUA, the difference in FEUA between breakfast and no breakfast cannot fully explain the difference in their observed sUA. <h3>Conclusions</h3> Skipping breakfast leads to a 0.4 mg/dL elevation in sUA over 24 hr. A decreased FEUA is partially responsible for the difference in sUA; however, there are likely other mechanisms involved as well. Routinely skipping breakfast might lead to even higher elevations in sUA. <h3>References</h3> Khanna D et al. Arthritis Care Res (Hoboken). 2012;64:1431–1446. Maclachlan MJ and Rodnan GP. Am J Med. 1967;42:38–57. <h3>Acknowledgement</h3> Research sponsored by Ardea Biosciences/AstraZeneca. Editorial support was provided by PAREXEL and funded by AstraZeneca. <h3>Disclosure of Interest</h3> S. Liu Employee of: Ardea Biosciences, Inc., J. Miner Employee of: Ardea Biosciences, Inc.
Dynamics of Mutations in Patients with ET Treated with Imetelstat
Authors: Elisabeth Oppliger Leibundgut, Monika Haubitz, Bart Burington, Oliver G. Ottmann, Gary Spitzer, Olatoyosi Odenike, Michael A McDevitt, Alexander Roeth, David S. Snyder, Gabriela M. Baerlocher
Journal: Blood (2015)
NLRP3 Inflammosome Polymorphisms Are Enriched in Myelodysplastic Syndrome Patients with Autoimmune Disorders
Authors: Syed A Mian, Austin G. Kulasekararaj, Aytug Kizilors, Kathy L McGraw, Shahram Kordasti, Stephan Menzel, Alexander e Smith, Pilar Perezabellan, David Sallman, Alan F. List, Ghulam J Mufti
Journal: Blood (2015)
Type II JAK2 Inhibitor NVP-CHZ868 Is Active in Vivo Against JAK2-Dependent B-Cell Acute Lymphoblastic Leukemias (B-ALLs)
Authors: Loretta S. Li, Shuo-Chieh Wu, Nadja Kopp, Joan Montero, Jeremy Ryan, Bjoern Chapuy, Jordy C. Van der Zwet, Jacob Layer, Oliver Weigert, Amanda L Christie, Alexandra N. Christodoulou, Huiyun Liu, Akinori Yoda, Francesco Hofmann, Fabienne Baffert, Eric Vangrevelinghe, Christoph Gaul, Thomas Radimerski, Anthony G. Letai, David M. Weinstock
Journal: Blood (2014)
Dual HER2-blockade with pertuzumab and trastuzumab in HER2-positive early breast cancer: a subanalysis of data from the randomized phase III GeparSepto trial
Authors: S. Loibl, C. Jackisch, A. Schneeweiss, S. Schmatloch, B. Aktas, C. Denkert, H. Wiebringhaus, S. Kümmel, M. Warm, S. Paepke, M. Just, C. Hanusch, J. Hackmann, J.-U. Blohmer, M. Clemens, S. Dan Costa, B. Gerber, K. Engels, V. Nekljudova, G. von Minckwitz, M. Untch
Journal: Annals of Oncology (2016)
P0254 : CCR5 expressed activated but not resting regulatory T cells accumulated in the tumor site and correlated with stages of hepatocellular carcinoma
Authors: J. Mahalingam, W.-C. Lee, C.-C. Lin, W.-T. Chen, C.-H. Huang, W.-J. Jeng, I-S. Sheen, S.-M. Lin, C.-Y. Lin
Journal: Journal of Hepatology (2015)
Mutations in Specific NOTCH1 Domains Convey a Distinct Phenotype in Adult Acute T-Lymphoblastic Leukemia.
Authors: Julia Thibaut, Nicola Goekbuget, Peter Martus, Thomas Burmeister, Stefan Schwartz, Dieter Hoelzer, Eckhard Thiel, Wolf K. Hofmann, Claudia D. Baldus
Journal: Blood (2007)
The JAK2 Kinase Inhibitor LS104 Induces Growth-Arrest and Apoptosis in JAK2V617F Positive Cells.
Authors: Daniel B. Lipka, Linda S. Hoffmann, Florian Heidel, Boyka Markova, Stefan Kasper, Frank Breitenbuecher, Thomas Kindler, Ross Levine, Joseph Elliot, Christoph Huber, Thomas Fischer
Journal: Blood (2007)
Coordinate Expression of Beta 2 Integrins and the Interleukin 23 Receptor Define a Pathogenic CD4+ T Cell Population That Induces Colonic Inflammation during Graft Versus Host Disease
Authors: Kimberle Agle, Vivian Zhou, Xiao Chen, Amy Beres, Richard Komorowski, Carolyn Taylor, Dipica Haribhai, Calvin Williams, James Verbsky, Wendy Blumenschein, Svetlana Sadekova, Eddie Bowman, Casey Weaver, Daniel Cua, William R. Drobyski
Journal: Blood (2014)
Identification and Characterization of T Cell Epitopes Deduced from RGS5, a Novel Broadly Expressed Tumor Antigen.
Authors: Cristina N. Boß, Frank Grünebach, Katharina M. Brauer, Toni Weinschenk, Lothar Kanz, Stefan Stevanovic, Hans-Georg Rammensee, Peter Brossart
Journal: Blood (2006)
Real World Outcomes of Less Well-Characterized Acute Leukemias: A Population-Based Survival Analysis Using SEER Registry (1973-2012)
Authors: Surbhi Sidana, Paul Elson, Aaron T. Gerds, Hetty E. Carraway, Anjali S. Advani, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Matt Kalaycio, Mikkael A. Sekeres, Sudipto Mukherjee
Journal: Blood (2015)
Higher Risk of Ischemic Stroke Associated with Factor XI Levels in Dyslipidemic Patients.
Authors: Maria Amparo Santamaria, Arturo Oliver, Jose Mateo, Roberto Belvis, Joan Marti-Fabregas, Juan C. Souto, Teresa Urrutia, Vallve Cristina, Montse Borrell, Jordi Fontcuberta
Journal: Blood (2004)
AB0895 Effects of Colchicine on Neutrophil Apoptosis in Patients with Familial Mediterranean Fever: Table 1.
Authors: E. Kaya, M. Nazıroglu, Y. Ugan, M. Sahin, A. Doğru, M. Aykur
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Familial mediterranean fever (FMF) is an autoinflammatory disease associated with a self-limiting attacks of fever and serositis. <h3>Objectives</h3> We aimed to investigate the assessment of apoptosis during acute attack and the effect of colchicine on apoptosis in patients with familial mediterranean fever (FMF). <h3>Methods</h3> This study was performed on 7 FMF patients during acute attack period and 7 age-sex matched healthy persons. Caspase 3 and caspase 9 were studied as the markers of apoptosis. Caspase 3–9 were studied again after neutrophils were incubated with colchicine in cell culture. <h3>Results</h3> Apoptosis level (0.21±0.009 versus 0.17±0.009, p&lt;0.05) and markers of apoptosis (caspase 3 and 9) was significantly higher in FMF group during attack period than the control group (p&lt;0.001). After the incubation with colchicine, apoptosis markers were found to provide a significantly decrease in comparison with attack period (p&lt;0.001). <h3>Conclusions</h3> Changing the structure of pyrin after mutation can cause failure in the regulation of inflammation and apoptosis. We suggest that defects in the regulation of apoptosis may play a role in the pathogenesis of FMF. Colchicine may reduces apoptosis as well as other mechanisms of action. More studies are needed to clarify the pathogenetic mechanisms of apoptosis in FMF. <h3>Disclosure of Interest</h3> None declared
Detection of Th1/Th2 Cytokines Is Useful for the Quick and Early Diagnosis of Hemophagocytic Syndrome in Children.
Authors: Yongmin Tang, Chan Liao, Xiaojun Xu, Chunfang Luo, Hua Song, Shilong Yang, Shuwen Shi, Binhua Pan, Yinghu Chen, Fenying Zhao, Hongqiang Shen, Baiqin Qian
Journal: Blood (2007)
PTU-026 The Yield of Bidirectional Investigations in Iron Deficiency Anaemia – Are Gastroscopies Redundant?: Abstract PTU-026 Table 1
Authors: MS Lau, J Schembri, DS Sanders, JM Hebden
Journal: Gut (2016)

<h3>Introduction</h3> Iron deficiency anaemia (IDA) is common, affecting 2–5% of people in the developed world. The BSG guidelines recommend bidirectional (upper and lower gastrointestinal [GI] tracts) investigations for patients with IDA in men, and in women who are postmenopausal, age &gt; 50 or with a family history of colorectal cancer (CRC). We aimed to evaluate the yield of bidirectional investigations for GI malignant and non malignant causes. <h3>Methods</h3> We prospectively collected data on patients attending a single consultant led IDA clinic from 2013–2015. IDA was defined as anaemia with microcytosis, low ferritin, raised zinc protoporphyrin or a compatible iron profile. Gastroscopy and colonoscopy were requested unless frailty, comorbidity, or patient choice dictated otherwise. Alternatives included barium studies, CT pneumocolon or CT abdomen. Coeliac and intrinsic factor (IF) antibodies, urine microscopy and renal tract ultrasound (unless patient had a CT) were also requested. Polyps or ulcers &lt;1 cm, non-haemorrhagic or non-friable oesophagitis, gastritis or Barrett’s oesophagus were not considered to be the cause for the iron deficiency. <h3>Results</h3> A total of 282 IDA and 11 patients with isolated hypoferritinaemia attended the clinic. 21 patients were excluded as they declined investigations, leaving 272 for analysis. 264 (97.1%) patients had UGI tests (240 gastroscopy/20 Barium swallow/4 CT) and 266 (97.8%) had LGI tests (198 colonoscopy/11 barium enema/57 CT). There were 170 symptomatic and 91 asymptomatic IDA patients, and 7 symptomatic and 4 asymptomatic hypoferritinaemic patients. CRC was found in 17 (6.4%) patients, with 10 and 7 in the symptomatic and asymptomatic IDA groups respectively. No malignancies were identified by any gastroscopies. An identifiable non-malignant cause of IDA was found in 8 (3%) gastroscopies. CT identified thickening of the gastric wall in an elderly patient who declined further investigations. In the isolated hypoferritinaemia group, there was no positive yield apart from 1 bleeding haemorrhoids. 1.5% (4/262) patients had pernicious anaemia and 0.7% (2/273) had coeliac disease. <h3>Conclusion</h3> The yield of UGI and LGI cancer was 0.38% (1/264) and 6.4% (17/266). There was no yield for malignancy from all 240 gastroscopies undertaken. This suggests that gastroscopies provide very limited diagnostic value as a first line investigation in patients with IDA without UGI symptoms or suspected coeliac disease. <h3>Disclosure of Interest</h3> None Declared
Dietary nitrogen alters codon bias and genome composition in parasitic microorganisms
Authors: Emily A. Seward, Steven Kelly
Journal: Genome biology (2016)

Genomes are composed of long strings of nucleotide monomers (A, C, G and T) that are either scavenged from the organism's environment or built from metabolic precursors. The biosynthesis of each nucleotide differs in atomic requirements with different nucleotides requiring different quantities of nitrogen atoms. However, the impact of the relative availability of dietary nitrogen on genome composition and codon bias is poorly understood. Here we show that differential nitrogen availability, due to differences in environment and dietary inputs, is a major determinant of genome nucleotide composition and synonymous codon use in both bacterial and eukaryotic microorganisms. Specifically, low nitrogen availability species use nucleotides that require fewer nitrogen atoms to encode the same genes compared to high nitrogen availability species. Furthermore, we provide a novel selection-mutation framework for the evaluation of the impact of metabolism on gene sequence evolution and show that it is possible to predict the metabolic inputs of related organisms from an analysis of the raw nucleotide sequence of their genes. Taken together, these results reveal a previously hidden relationship between cellular metabolism and genome evolution and provide new insight into how genome sequence evolution can be influenced by adaptation to different diets and environments.
Non-Myeloablative Allogeneic Transplantation (NMT) with T-Cell Replete Graft for Relapsed Chemosensitive Follicular Lymphoma (FL): Donor Lymphocyte Infusion (DLI) To Convert Stable Mixed Chimerism to Full Donor Chimerism Is Not Necessary in the Absence of Disease Progression.
Authors: Issa F. Khouri, Ming-Sheng Lee, Rima M. Saliba, Sandra A. Acholonu, Rosamar Valverde, Martin J. Korbling, Ricahrd E. Champlin
Journal: Blood (2005)