tbuckley/cabot-search huggingface dataset:
Abstract 145: Finding correlations between CtBP expression and breast cancer risk factors.
Authors: Mofiyinfoluwa A. Obadina
Journal: Cancer Research (2013)

Abstract In women, breast cancer is ranked second in cancer deaths; almost 40,000 deaths are expected and over 225,000 new cases are expected. Research has shown that breast cancer prevalence and mortality are influenced by various factors including race and lifestyle. Studies have indicated racial disparity whereby young women of African descent have higher breast cancer mortality rate and this could be partly explained by higher occurrence of more aggressive breast cancer forms that exhibit characteristics of epigenetically re-programmed reactivation of embryonic processes that promote tumor invasion, spread and resistance to chemotherapy. These are features common to certain breast cancer subtypes including basal-like and triple negative breast cancers, which occur more frequently in younger African American women. We are focusing on epigenetic factors that explain this disparity as this understanding will help provide population-based approach to detecting and treating breast cancer. C-terminal Binding Protein (CtBP) is a family of epigenetic regulators that undergoes dimerization which is stimulated and stabilized by NADH, a product of metabolism. CtBP has been shown to induce epithelial-to-mesenchymal transition (EMT), an embryonic program that increases tumor invasion and metastasis; we therefore hypothesize that CtBP likely plays a role in tumor progression. Research from our lab has shown an elevated level of CtBP present in the nuclei of more clinically aggressive breast cancer subtypes.. To find the correlation between CtBP expression and other patient factors such as race, age, BMI and hormone receptor status we have begun to screen several breast cancer patient cohorts obtained from larger minority serving medical centers around the country. Our preliminary findings reveal that elevated levels of CtBP expression in patient tumor samples shows a statistically significant correlation with shortened median survival. Moreover, random sampling of a small population of these cohorts suggests that the correlation between CtBP and poor clinical outcome is greater in women of African heritage compared to European descent. How epithelial features and stromal attributes of the tissue microenvironment contribute to this correlation is currently under investigation. Citation Format: Mofiyinfoluwa A. Obadina. Finding correlations between CtBP expression and breast cancer risk factors. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 145. doi:10.1158/1538-7445.AM2013-145
Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function
Authors: Preben G Berthelsen, Paul E Marik
Journal: New England Journal of Medicine (2015)

To the Editor: In the July 30 issue of the Journal, Niemann and colleagues published their investigation on therapeutic hypothermia in deceased organ donors and kidney-graft function.1 The investigation was initiated on March 20, 2012, and registered with ClinicalTrials.gov 5 months later (August 21, 2012). According to the registration (NCT01680744), the primary outcome measure was the change in renal function (as determined by levels of creatinine and cystatin C) between neurologic death and organ recovery in donors randomly assigned to normothermia or hypothermia. No secondary outcome measures were stipulated. When Niemann et al. report the results of their investigation, the primary outcome has been changed to delayed graft function in the kidney recipients. This change resulted in a positive outcome of the authors’ intervention. We believe that the results of this investigation should be taken to suggest only a hypothesis rather than to provide evidence for a benefit of induced donor hypothermia in kidney transplantation. Preben G. Berthelsen, M.D.
CONSTITUTIONAL FACTORS IN THE PROGNOSIS OF SCHIZOPHRENIA
Authors: NATHAN S. KLINE, A. N. OPPENHEIM
Journal: American Journal of Psychiatry (1952)

1. Hebephrenics have a significantly poorer prognosis than the rest of the sample. Except for this, the relationship between diagnosis and prognosis was not found to be significant. 2. A significant relationship exists between mesomorphy and paranoid schizophrenia as also between ectomorphy and hebephrenic schizophrenia. 3. When the endomorphs were contrasted to the combined ectomorphic and mesomorphic groups they were found to have a significantly poorer prognosis. A larger proportion of endomorphs was still hospitalized than were patients of other body types. The conclusion of the first review, that mesomorphy was related to good prognosis, did not hold true for the longer time period.
Endoscopic ultrasound-guided transesophageal drainage of a mediastinal pancreatic pseudocyst using a novel lumen-apposing metal stent
Authors: J. Gornals, C. Loras, R. Mast, J. Botargues, J. Busquets, J. Castellote
Journal: Endoscopy (2012)

There have been a few previous reports of transesophageal endoscopic ultrasound (EUS)-guided drainage of pancreatic fluid collections (PFC). In these reports the drainage modality has been a single aspiration or deployment of a plastic stent [1] [2] [3] [4]. We report a patient who underwent transesophageal EUS-guided drainage of a mediastinal PFC using a novel lumen-apposing metal stent.
AB1432-HPR Level of education, occupation and sleep disorders in patients with rheumatoid arthritis and relationship with disease activity
Authors: L. Villarreal, L. Amador, J. Bello, A. Urbina, D. Zambrano, P. Santos-Moreno
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The rheumatoid arthritis (RA), as known, causes inability in various performance areas mostly in the musculoskeletal. Reduced physical activity, substantial disability and also sleep disorders have previously been described in people with RA. <h3>Objectives</h3> The aim of this study was to describe the socio-demographic profile and sleep disorders in RA patients from a specialized RA clinic in Colombia. <h3>Methods</h3> A descriptive cross-sectional study was performed in a specialized clinic dedicated to care patients with rheumatoid arthritis (RA). 127 patients were included in the study, which were seen by the area of psychology, which information was collected through semi-structured interviews and non-probability sampling. Descriptive epidemiology was applied for continuous variables, using measures of central tendency and dispersion for categorical and qualitative variables by averages and percentages. By means of Pearson's statistics it was analyzed bi-variated correlations. <h3>Results</h3> The total sample of patients was 127, 103 (81.1%) were women and 24 (18.9%) were men, average DAS28-3.5±0.8. Average age is 53.4 years. 36% was married, 19.8% is divorced, 15.5% is single and others undefined. Related with the occupation, 31% is retired because age and the 17.9% have handicap retirement pay; 19.4% is dedicated to the housekeeping and 31.7% were working. Related to education 19.4% no education, 25% had elementary school, 29% didn't finish high school, 18.2 were technical and only 8.4% finish high school. Finally, 70 (55.2%) of patients report sleep disorders and 57 (44.8%) don't. It was found that 67 (95.7%) of reported patients linked sleep disorder with pain. Among type of sleep disorders were seen: primary insomnia (13.8% of women and 21.5% of men), nonspecific dyssomnias (6.7% of women and 7.9% of men), circadian rhythm disorder (5.1% of women and 13.2% of men), and hypersomnia in 0.93% of women. It was established a correlation between sleep disorders and disease activity (p&lt;0.04), but not between level of education or occupation with disease activity. <h3>Conclusions</h3> According to these findings sleep disorders are likely present in almost half of patients with RA and in many cases linked with pain. Primary insomnia and circadian rhythm disorder are more prevalent in men (probably because many of them work in night private guard). A higher DAS28 is expected to be associated with restless sleep, but level of education don't influence on disease activity. <h3>Disclosure of Interest</h3> None Declared
Successful Bone-Marrow Transplantation for Infantile Malignant Osteopetrosis
Authors: Peter F. Coccia, William Krivit, Jaroslav Cervenka, Carlyle Clawson, John H. Kersey, Taehwan H. Kim, Mark E. Nesbit, Norma K. C. Ramsay, Phyllis I. Warkentin, Steven L. Teitelbaum, Arnold J. Kahn, David M. Brown
Journal: New England Journal of Medicine (1980)

A five-month-old girl with autosomal-recessive osteopetrosis received a bone-marrow transplant from her five-year-old HLA-MLC-identical brother after preparation with cyclophosphamide and modified total-body irradiation. Engraftment was documented by chromosomal analysis. Anemia, thrombocytopenia, and leukoerythroblastosis corrected within 12 weeks of transplantation. Low serum calcium and elevated serum alkaline and acid phosphatase levels became normal. Serial x-ray studies revealed bony remodeling and new nonsclerotic bone formation. A pretransplantation bone biopsy revealed small marrow spaces, rare marrow elements, increased osteoclasts, and no bony resorption. After transplantation, osteoclasts were actively resorbing bone, and medullary cavities contained normal bone marrow. Fluorescent Y-body analysis after transplantation revealed donor (male) osteoclasts and recipient (female) osteoblasts. Monocyte bactericidal activity, markedly decreased before transplantation, became normal. Vision, hearing, growth, and development were progressively improving 16 months after transplantation. Allogeneic bone-marrow transplantation appears to be the treatment of choice in this fatal disorder.
Lobular breast carcinoma as a possible candidate phenotype for recessively inherited breast cancer.
Authors: HL Olsson
Journal: Cancer Research (2009)

Abstract Abstract #1045 Background:There are reasons to believe that beside dominant inheritance of breast cancer other modes of inheritance as recessive inheritance ought to exist. Studies have however failed to find recessive inheritance.Patients developing lobular carcinoma who often show multifocal and bilateral presentation could be a candidate phenotype for such a recessive disorder. Further a previous hypothesis suggests that lobular carcinomas develop from a more mature breast tissue later in reproductive life than f.i. tumours of ductal origin. Therefore lobular carcinomas ought to present at a later age and breast cancer without other cancer sites would be the predominant tumour occurring in such families.&amp;#x2028; Objective: To study breast cancer patients and relate their type of family history (vertical, horizontal or combined) to tumour histology and then especially the number of lobular carcinomas in relation to age at presentation in order to possibly identify a recessive phenotype for breast cancer.&amp;#x2028; Material and methods: Two different sets of patients have been used. First from a consecutive series of breast cancer patients(n=1682) seen at the Department of Oncology, University Hospital, Lund between 1980-2002, randomnly seen by one physician, a comprehensive standardized family history was taken. Family history was classified into 4 groups; vertical (sister-sister), horizontal (mother-daughter), combined or none. Family history was related to whether the patient had developed lobular carcinoma and the age at tumour presentation (≤50 years or above 65 years). Secondly in patients with ≥4 malignant tumours of which at least one is a breast cancer, n=67, (identified through the population based cancer registry) extended family trees were used and related to the tumour histology of the proband (lobular cancer or not).&amp;#x2028; Results: Patients with a horizontal family history (sister-sister) had more lobular carcinomas (18.8%) compared with the other groups (11.3%), p=0.05. The relationship was strongest for patients with disease above 65 years of age (31% lobular carcinoma for horizontal vs 10.9% for the others), p=0.0003, but not significant for disease presentation below age 50.&amp;#x2028; Conclusion: A horizontal family history (sister-sister) was significantly associated with lobular carcinoma developing at higher ages. These type of families may be the phenotype for studies of recessive genes in breast cancer, while in patients with multiple tumours of various types lobular carcinoma is not associated with a horisontal family history. This indicates that the possible phenotype for a recessive disorder encompassing lobular carcinoma should exhibit breast cancer as the only tumor type in the family. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1045.
IMPACTACIÓN ESOFÁGICA DE CUERPOS EXTRAÑOS COMO URGENCIA ENDOSCÓPICA. ANÁLISIS DE NUESTRA EXPERIENCIA. -
Authors: J Rodríguez Sánchez-M, M Alonso LaBlanca, M Adán Alonso, B López Viedma, C Verdejo Gil, A Hernández Albujar, F Domper Bardají, R Lorente Poyatos, E De la Santa, P Olivencia Palomar, R Patón Arenas, J Olmedo Camacho, R Martín Escobedo, E Rodríguez Sánchez
Journal: Endoscopy (2011)

Introducción: La impactación por cuerpos extraños (CEs) esofágicos es un hecho frecuente en la práctica clínica diaria, siendo la segunda causa de urgencia endoscópica tras la hemorragia digestiva alta. Clásicamente se ha descrito, que la mayoría de CEs que alcanzan el tracto digestivo superior no se impactan, requiriendo atención médica en un 10%-20% de casos y en un 1% tratamiento quirúrgico. Sin embargo recientemente se han publicado que en población con ingesta intencionada, la tasa de intervención endoscópica oscila entre un 63% a un 76%, con una tasa de intervención quirúrgica cercana del 10%. Afortunadamente las tasas de mortalidad registradas son extremadamente bajas.
Involvement of notch and RUNX pathways in human breast cancer.
Authors: T Yong, S Meyers, N Davis, A Sun
Journal: Cancer Research (2009)

Abstract Abstract #6021 Background: Recent studies have demonstrated that the Notch signaling and the RUNX-mediated transcription pathways converge in mammalian hematopoiesis where they regulate proliferation and development. Evidence from in vitro experiments, mouse models and human tumors demonstrate that Notch signaling plays an oncogenic role in human breast cancer. Studies of RUNX factors involvement in human breast cancer suggest that the Core Binding Factor [CBF, a heterodimeric transcription factor composed of a RUNX DNA binding protein (RUNX1, RUNX2, or RUNX3) and a single non-DNA binding component termed CBFβ] participates in regulating the malignant phenotype of the tumor. Thus, the RUNX factors are primarily important to Notch signaling, and it seems likely that Notch:RUNX cross-talk will be important to cellular function and disease in a variety of tissue types. Here, we present our findings on cross-talk between Notch and RUNX pathways, which will lead to a better understanding of Notch and RUNX regulated transcription in breast carcinogenesis.&amp;#x2028; Material and Methods: The expression and localization of the Notch1 NICD and RUNX2 in normal breast tissue and breast tumor were determined by immunohistochemistry on human breast tissue microarray obtained from Feist-Weiller Cancer Center. The expression profiles of Notch and RUNX were evaluated by real-time RT-PCR, Western Immunoblot, and electrophoretic mobility shift assay (EMSA).&amp;#x2028; Results and Discussion: We found activated Notch1 and RUNX2 predominantly expressed in the cytoplasm and nucleus of cells in human normal breast tissues, respectively. However, in human breast cancer tissue samples, activated Notch1 was found in the nucleus in a high proportion of the cancer cells, while RUNX2 presence in the nucleus was much reduced and this could be due to mislocalization, over-expression or delayed degradation of the proteins. The major transcript in the breast cancer cell lines is RUNX1, but by EMSA, RUNX2 factor is the predominant biologically active and functional form of RUNX factors associated with breast cancer cell line-derived CBF. Transcript degradation and protein stability may play significant role in the regulation of RUNX factors in breast carcinogenesis. Down-regulation of CBFβ was found to affect Notch signaling in breast cancer cells and this may lead to the identification of new therapeutic targets for the successful treatment of breast cancer. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6021.
Abstract P3-06-12: Effect of TOP2A and cMYC gene copy number on outcome in a Phase II trial of adjuvant TC (Docetaxel/Cyclophosphamide) plus trastuzumab (HER TC) in HER2-positive early stage breast cancer
Authors: S Jones, R Collea, D Paul, S Sedlacek, A Favret, I Gore, DL Lindquist, FA Holmes, MAK Allison, MS Steinberg, C Stokoe, RM Portillo, M Crockett, Y Wang, A Lina, NJ Robert, J O'Shaughnessy
Journal: Cancer Research (2012)

Abstract Introduction: Approximately one-third of HER2+ early stage breast cancer (ESBC) patients have TOP2A-amplified breast cancer, the subpopulation known to benefit from anthracycline use (Press et al, JCO 2011). Data are needed to evaluate whether outcomes in ESBC patients treated with nonanthracycline-based regimens like docetaxel and cyclophosphamide + trastuzumab (HER TC) are affected by TOP2A or cMYC gene copy number. Methods: This was an open-label, phase II study of HER TC in HER2+ breast cancer patients. Outcome data have been previously reported (Jones et al, SABCS 2011, PD07-03). Tissue was collected to review HER2, cMYC, and TOP2A gene copy number at a central reference laboratory. HER2, cMYC, and TOP2A amplification was defined as FISH ratio &amp;gt;2, and deletion was defined as FISH ratio &amp;lt;1. Every 21 days, patients received T 75mg/m2 IV and C 600mg/m2 IV, plus weekly H 4mg/kg IV (loading dose) and 2mg/kg IV thereafter for a total of 4 cycles. After 4 cycles of TC+H, patients continued on H for 1 year on a 3-week schedule. The primary endpoint was disease-free survival (DFS) at 2 years with continued follow-up for 3 years. Secondary endpoints were overall survival (OS) and safety. Results: 493 patients with HER2+ ESBC were enrolled. From the 493 patients, 438 (89%) tissue samples were available and analyzed at Caris Diagnostics (Phoenix, AZ) to test for TOP2A, cMYC, and HER2 gene copy number by FISH. HER2 status was confirmed as positive in 87% of samples. Results for TOP2A, cMYC, and HER2 were generated in 438, 436, and 438 samples, respectively. TOP2A was classified as amplified in 43%, normal in 30%, deleted in 27%. cMYC was classified as amplified in 99(23%), normal in 246(56%), and deleted in 91(21%). Three-year DFS and OS in TOP2A and cMYC status as well as ER and Nodal status are depicted in Table 1. Multivariate analyses of age, nodal status, ER status, and gene expression shown below in Table 2 indicate that neither cMYC nor TOP2A status had an effect on outcome. Only nodal and ER status affected outcome. Conclusion: Outcome (DFS + OS) in a phase II study of a nonanthracycline regimen (TC) coupled with H was unaffected by cMYC or TOP2A gene copy number status. Only ER and nodal status showed an effect in a multivariate analysis. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-06-12.
SAT0362 Quality of life and pain evaluation in patients with and without self-reported osteoporosis - corpo study: Comprehending osteoporosis real perception and overview:
Authors: L. Cunha-Miranda, S. Fernandes, E. Simões, N. Gonçalves, E. Leiria, L. Nogueira
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The awareness of osteoporosis (OP) symptoms and evolution may impact on patients daily activities. Osteoporosis may cause pain, reduce physical functioning and mobility also resulting in social isolation and depression<sup>1</sup>. <h3>Objectives</h3> To evaluate Health Related Quality of Life (HRQoL) and pain in subjects with and without self-reported OP, in the general population and in a high risk of fracture (HRF) population. <h3>Methods</h3> Cross sectional survey including a representative sample of Portuguese population aged ≥50 years (random route method, door to door) and a HRF population (convenience sample, selected randomly from nursing homes and long term facilities from Portugal). Inclusion criteria for HRF population were age ≥50 years, history of femoral neck fracture on the 24 months prior and absence of cognitive limitations. SF12 scale and ECOS were used. <h3>Results</h3> From the 2007 subjects of the general population (mean age of 65.3±10.4 years; 55.2% female), 62 (3.1; CI: 2.4%&gt;3.9%) self-reported OP. HRF population included 419 subjects (mean age of 78.3±7.8;70.4% were female), 37.5% (n=157; CI: 32.9%&gt;42.2%) self-reported OP. Significant differences were found for SF12 dimensions between subjects in general population with and without self-reported OP (Table 1). In HRF population no significant differences were found (Table 1). Regarding ECOS, significant differences were found between general population and HRF population with self-reported OP (2.74±0.79 vs. 3.15±0.85, p=0.001). No significant differences were found in ECOS pain items between general population and HRF population with self-reported OP (ECOS items 1 to 5: p=0.410; p=0.134; p=0.086; p=0.323; p=0.144, respectively). <h3>Conclusions</h3> The evidence suggests that the HRQoL on the general population with self-reported OP was significantly lower in comparison with the population without OP, although no significant differences were found between groups in the HRF population. That could be partial explained by the presence of a low hip fracture in this group. <h3>References</h3> Bianchi ML, Orsini MR, Saraifoger S, Ortolani S, Radaelli G, Betti S. Quality of life in post-menopausal osteoporosis. Health Qual Life Outcomes 2005;3:78. <h3>Disclosure of Interest</h3> None Declared
The learning curve for EUS-guided drainage of symptomatic intraabdominal collections: experience of a single endoscopist in a general hospital
Authors: Ang Tiing Leong
Journal: Endoscopy (2011)

Introduction and aim: EUS-guided drainage is now an established treatment modality for symptomatic intraabdominal fluid collections. There is a lack of data on the learning curve required to master this technique. This study evaluated the efficacy and safety of EUS-guided drainage of intraabdominal fluid collections in relation to the experience of a single endoscopist. Methods: The clinical data of consecutive patients with symptomatic intraabdominal fluid collections referred for endoscopic drainage during the period from December 2006 to August 2010 were maintained in a prospective database and reviewed. All procedures were performed by a single endoscopist (ATL) trained in ERCP and EUS/EUSFNA who observed but did not have any hands-on training in EUS-guided drainage during his fellowship.
The contribution of comparative research to the development and testing of life history models of human attachment and reproductive strategies
Authors: Dario Maestripieri
Journal: Behavioral and Brain Sciences (2009)

Abstract Research with nonhuman primates can make important contributions to life history models of human attachment and reproductive strategies, such as: including parental responsiveness into female reproductive strategies, testing the assumption that adult attachment is a reproductive adaptation, assessing genetic and environmental effects on attachment and reproduction, and investigating the mechanisms through which early stress results in accelerated reproductive maturation.
Cutaneous Melanosis in Peripheral Cortisol Resistance
Authors: Rivo Rakotoarivelo, Mahaliana Ratsarazaka
Journal: New England Journal of Medicine (2014)

A 47-year-old-man presented with orthostatic hypotension and cutaneous hyperpigmentation. He was infected with HIV and had cryptococcal meningitis, pulmonary TB, and lung abscess. Examination revealed cachexia and melanodermia on the cheeks, nose, and chin and around the mouth.