tbuckley/cabot-search huggingface dataset:
OP0217 Frequent Detection of Inflammation and Fat Infiltration Suggestive of Spondyloarthritis on MRI of the Entire Spine in Healthy Subjects and Patients with Mechanical Back Pain
Authors: U. Weber, Z. Zhao, V. Zubler, S. M. Chan, R. G. Lambert, M. Ostergaard, S. J. Pedersen, W. P. Maksymowych
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Mechanical back pain (MBP) patients and healthy subjects may show spinal MRI lesions suggestive for spondyloarthritis (SpA) such as corner inflammatory lesions (CIL) or corner fat lesions (CFL). There are few data about their frequency and whether they may result in a false positive classification of controls as having SpA. <h3>Objectives</h3> To assess the frequency of false positive classification as SpA in controls consisting of MBP patients and healthy volunteers, and to evaluate which MRI lesion type has the highest impact on misclassification. <h3>Methods</h3> The study sample comprised 2 independent cohorts A/B of 130 consecutive patients with back pain ≤50 years newly referred to 2 university clinics, and 20 healthy controls, in whom MRI scans of the entire spine were available. Patients were classified according to clinical examination and pelvic radiography as having non-radiographic SpA (nr-axSpA; n=50), ankylosing spondylitis (AS; n=33), or MBP (n=47). Age-matched healthy controls in cohort A were recruited according to the Nordic Questionnaire from hospital staff of the same clinic that also recruited the SpA patients. Spinal MRI were assessed by 4 blinded readers according to the Canada-Denmark MRI definitions for spinal lesions [1, 2]. Readers recorded bone marrow edema (BME) and fat infiltration (FI) in the central, lateral and posterior compartment of all 23 discovertebral units. The mean number (percentage) of controls misclassified as having SpA by the 4 readers and the principal spinal lesions indicative of SpA were analysed descriptively. <h3>Results</h3> 33.9%/28.0% of MBP patients in cohorts A/B, and 26.3% of healthy subjects in cohort A were misclassified as having SpA by global assessment of MRI of the entire spine. Both BME and FI in varying percentages were the most important MRI lesions leading to this misclassification. The mean number of CIL and CFL observed in controls was lower than in SpA patients. Mean percentage of false positive controls, principal MRI lesions responsible for misclassification, and mean number for CIL and CFL on spinal MRI in cohort A/B <h3>Conclusions</h3> 26% to 34% of healthy controls and patients with MBP were misclassified as having SpA by evaluation of MRI of the spine alone. Caution is warranted if a classification of SpA is based on MRI of the spine alone. <h3>References</h3> Lambert R et al. J Rheumatol 2009;36 suppl 84:3. Ostergaard M et al. J Rheumatol 2009;36 suppl 84:18. <h3>Disclosure of Interest</h3> None Declared
BRAIN TUMOR SURGERY NAVIGATION SYSTEM BASED ON UPDATING PREOPERATIVE IMAGES USING POSITIONAL INFORMATION OF SURGICAL TOOLS
Authors: T. Wakabayashi, M. Fujii, A. Natsume, K. Motomura, Y. Hayashi, K. Mori
Journal: Neuro-Oncology (2014)

BACKGROUND: Based on a surgical navigation system, image-guided surgery has been widely performed in neurosurgery. A surgical navigation system dynamically presents the positions of the surgical tools on reference images, which are usually generated from MRI images taken before the surgery. Although the organs are deformed by the operative procedure during the surgery, the reference images in the surgical navigation system cannot represent the organ deformation caused by the operative procedures during surgery. Therefore, the reliability of the reference images in the navigation system decreases as the surgical procedure progresses. METHODS: To solve this problem, we introduced a new concept of surgical navigation system which processes information interactively between the real and the virtual space, namely, updating preoperative images using the positional information of surgical tools. RESULTS: To estimate the resected regions, our proposed system utilizes the positional information of the surgical tools that can be tracked by a surgical navigation system. The system provides surgeons 3D virtual images closer to the real surgical field. CONCLUSIONS: This helps surgeons to understand 3D surgical anatomy in real time during surgery. SECONDARY CATEGORY: n/a.
Abstract PD07-07: Indicators of Homologous Recombination Deficiency in Breast Cancer and Association with Response to Neoadjuvant Chemotherapy
Authors: EH Lips, L Mulder, J Hannemann, N Laddach, M-JFTD Vrancken-Peeters, MJ van de Vijver, J Wesseling, PM Nederlof, S. Rodenhuis
Journal: Cancer Research (2010)

Abstract Background: Tumors with homologous recombination (HR) deficiency are highly sensitive to DNA double strand break (DSB) inducing agents, such as alkylating agents and poly (ADP-ribose) polymerase (PARP)-inhibitors. BRCA1 or BRCA2- mutated tumors, which are HR deficient, have characteristic DNA gains and losses that can be assessed by an array Comparative Genomic Hybridization (aCGH) classifier, one for BRCA1 mutations and one for BRCA2 mutations. We have studied these aCGH profiles together with several other HR deficiency indicators in sporadic breast cancers and we have correlated their presence to neoadjuvant chemotherapy response. Material and Methods: A total of 163 HER2-negative pre-treatment biopsies were examined, procured from sporadic breast cancer patients scheduled to receive neoadjuvant therapy with doxorubicin and cyclophosphamide. Triple negative (TN) and estrogen receptor positive (ER+/HER2-) tumors were analyzed separately. aCGH was performed to assess BRCA1-like and BRCA2-like profiles. In addition, BRCA1 promoter methylation, BRCA1 mRNA expression and amplification of the BRCA2-inhibiting gene EMSY were analyzed. Response to neoadjuvant treatment was assessed by measuring pathological complete remission (pCR) and near pCR at the time of surgery. Results: Inactivation of BRCA1 was frequent in TN tumors: 57% of these tumors showed a BRCA1-like profile at aCGH. BRCA 1 promoter methylation and reduced BRCA1 mRNA expression were observed in 25% and 36% of the TN tumors, respectively. The BRCA1-like aCGH profile was not clearly associated with a better neoadjuvant treatment response (58% vs. 48%, p=0.47). In ER+ tumors, a BRCA2-like aCGH profile and the amplification of the BRCA2 inhibiting gene EMSY were frequently observed (43% and 13% respectively). A BRCA2-like aCGH profile was associated with a significantly higher response rate (35% vs. 14%, p=0.014). EMSY amplification and a BRCA2-like aCGH profile occurred together in only one case, suggesting mutual exclusivity. EMSY was not associated with treatment response, questioning the role of EMSY in HR deficiency. Conclusion: Alterations associated with BRCA1 inactivation are present in about half of the TN breast cancers, but were not predictive of chemotherapy response. In ER+/HER2- tumors, the BRCA2-like aCGH profile predicts sensitivity to DSB-inducing chemotherapy, and possibly as well to new targeted agents, such as the PARP inhibitors. After validation in independent series the aCGH classifiers may lead to a diagnostic test that could assist in neoadjuvant treatment selection. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr PD07-07.
YIELD OF MYOCARDIAL PERFUSION IMAGING IN ACUTE CHEST PAIN PATIENTS WITH NEGATIVE ECG AND BIOMARKERS
Authors: Gavin W. Hickey, Daniel Nguyen, Deepak Pasupala, Mukul Khanna, Sanaz Abedzadeh Anaraki, Zachary Rhinehart, Omar Batal, Jeremy Markowitz, Saurabh Malhotra, Prem Soman
Journal: Journal of the American College of Cardiology (2015)
AB0885 Spondyloarthritis in rana, norway. Prevalence and subgroups
Authors: I.M. Hansen, H. Nossent, Ø. Førre
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Spndyloarthritis is a relatively common rheumatic disease with prevalences ranging from 0,31% to 1,9% in different populations and investigated with different methods. Patients have inflammatory backpain or peripheral arthritis, enthesitis or dactylitis or both. New treatment possibilities with biologic agents and new imaging methods with MRI and Ultrasound has led to increased interest in diagnosis and assessment og these patients. <h3>Objectives</h3> To study the prevalence of Spondyloarthritis and its subgroups in a region in Norway <h3>Methods</h3> There has been a rheumatologic service at the hospital in Mo i Rana since 1994.Patients were recruited from the patient registry in the hospital in Mo i Rana, from primary physicians and physical therapists and from an ad in the local newspaper. Patients were assessed after ESSG-criteria, Clinical investigation including joint count and spinal mobility was done. BASDAI, BASFI and MHAQ was collected. X-ray and MRI of sacroiliacal joints were done in patient with inflammatory backpain. Patients 1st degree relatives older than 15 years of age were invited to the study and were sent a questionnaire which included questions about cronic synovitis or inflammatory backpain. Relatives with suspicious synovitis or inflammatory backpain in their history were invited to clinical investigation. The rheumatology department in Bodø is 240 kms from Mo i Rana. Some rheumatic paients from Rana are followed i Bodø. The patient registry in Bodø was searched for patient with spondyloarthritis from the Rana area. <h3>Results</h3> Results SpaPatients recruited from patientregistry in Mo I Rana 211 SpaPatients recruited from relatives 113 Spa Patients recruided from ad in local paper 22 Total Spa patients 346 <b>Subgroups</b> AS 71 20% Psoriativc arthritis 149 43% IBD 18 5,2% REA 15 4,3% Uspa 120 35% <b>Patientregistry in Bodø</b> Spa 72 Total SPA in Rana 346+72=418 Population at risk 26.000 <b>Prevalence of Spa</b> <b>1,6%</b> <h3>Conclusions</h3> Spa is a common rheumatic disease with a prevalence of 1,6% Psoa is the largest subgroup followed by Uspa and AS <h3>References</h3> Buschiazzo, E., J. A. Maldonado-Cocco, et al. (2011). Epidemiology of spondyloarthritis in Argentina. The American Journal of the Medical Sciences 341(4): 289-292. <h3>Disclosure of Interest</h3> None Declared
DIFFERENTIAL INTERVENTRICULAR EXPRESSION OF MICRORNA-21, -93, -151, -221 AND -582, IN DILATED CARDIOMYOPATHY WITH BIVENTRICULAR DYSFUNCTION
Authors: Jeffery Powers, Ryan C McCormick, Gino Grifoni, David EM. Roul, Gayani Nanayakkara, Fabio A Recchia, Emily Tsai
Journal: Journal of the American College of Cardiology (2015)
Studies of Cerebral Hemodynamics in Aortocranial Disease
Authors: Joseph F. Fazekas, Robert H. Yuan, Allen D. Callow, Robert E. Paul, Ralph W. Alman
Journal: New England Journal of Medicine (1962)

AUTOPSY studies and the increasing use of arteriography have revealed an unsuspected frequency of occlusive disease of the aortocranial vessels as a cause of cerebral ischemia.1 2 3 4 5 On clinical grounds alone it has been practically impossible to differentiate intracerebral arterial insufficiency from stenosis or occlusion of the internal carotid or vertebral basilar system.6 The measurement of total cerebral blood flow and vascular resistance has not been considered to have clinical applicability because of the frequent lack of correlation with the functional status of the cerebrum.7 It is the purpose of this report to emphasize the fact that measurement of the cerebral . . .
637 A NMR METABONOMIC APPROACH TO EXPLORE EARLY BIOMARKERS OF HEPATOCELLULAR CARCINOMA IN THE EUROPEAN PROSPECTIVE INVESTIGATION INTO CANCER AND NUTRITION (EPIC)
Authors: A. Fages, P. Ferrari, C. Pontoizeau, V. Fedirko, B. Elena-Herrmann, M. Jenab, T. Duarte-Salles
Journal: Journal of Hepatology (2013)
Congenital Agenesis of Right Parotid Gland Confounds MIBG Scan Interpretation in Craniocervical Neuroblastoma
Authors: Don Udall, Steve Y. Cho
Journal: Clinical Nuclear Medicine (2011)

A 10-month-old boy with left infraorbital temporal neuroblastoma presented for I-123 metaiodobenzylguanidine scan with SPECT/CT for staging. Symmetrical metaiodobenzylguanidine uptake in salivary glands is usually considered normal. In this case of right parotid agenesis, symmetrical uptake was misleading. Tumor in the right mandibular ramus masqueraded as normal parotid gland. Repeat imaging 3 months after chemotherapy revealed absence of physiologic right parotid gland activity. Correlation with CT from SPECT/CT demonstrated right parotid agenesis, confirmed on MRI. Few cases of unilateral parotid agenesis are reported in published literature. We also discuss the potential added value of higher-quality CT images in SPECT/CT tumor imaging.
Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice
Authors: Kirsten C. Verhein, Zachary McCaw, Wesley Gladwell, Shweta Trivedi, Pierre R. Bushel, Steven R. Kleeberger
Journal: Environmental Health Perspectives (2015)

Ozone is a highly toxic air pollutant and global health concern. Mechanisms of genetic susceptibility to ozone-induced lung inflammation are not completely understood. We hypothesized that Notch3 and Notch4 are important determinants of susceptibility to ozone-induced lung inflammation.Wild-type (WT), Notch3 (Notch3-/-), and Notch4 (Notch4-/-) knockout mice were exposed to ozone (0.3 ppm) or filtered air for 6-72 hr.Relative to air-exposed controls, ozone increased bronchoalveolar lavage fluid (BALF) protein, a marker of lung permeability, in all genotypes, but significantly greater concentrations were found in Notch4-/- compared with WT and Notch3-/- mice. Significantly greater mean numbers of BALF neutrophils were found in Notch3-/- and Notch4-/- mice compared with WT mice after ozone exposure. Expression of whole lung Tnf was significantly increased after ozone in Notch3-/- and Notch4-/- mice, and was significantly greater in Notch3-/- compared with WT mice. Statistical analyses of the transcriptome identified differentially expressed gene networks between WT and knockout mice basally and after ozone, and included Trim30, a member of the inflammasome pathway, and Traf6, an inflammatory signaling member.These novel findings are consistent with Notch3 and Notch4 as susceptibility genes for ozone-induced lung injury, and suggest that Notch receptors protect against innate immune inflammation.
PREDICTORS OF FAILED REPERFUSION IN UNCERTAIN CANDIDATES FOR CATHETER THROMBUS ASPIRATION
Authors: David Marti, Jose Luís Mestre, Luisa Salido, María Jesus Esteban, Eduardo Casas, Jaime Pey, Marcelo Sanmartín, Rosana Hernández-Antolín, Jose Luís Zamorano
Journal: Journal of the American College of Cardiology (2016)
Long-Term Treatment of Osteopetrosis with Recombinant Human Interferon Gamma
Authors: L. Lyndon Key, Ramona Marie Rodriguiz, Steven M. Willi, Nancy M. Wright, Heather C. Hatcher, David R. Eyre, Joel K. Cure, Paul P. Griffin, William L. Ries
Journal: New England Journal of Medicine (1995)

Congenital osteopetrosis is a rare osteosclerotic bone disease characterized by both a defect in osteoclastic function and reduced generation of superoxide by leukocytes. The disease is frequently fatal during the first decade of life. A six-month trial of therapy with recombinant human interferon gamma-1b in eight patients with osteopetrosis provided evidence of benefit, prompting this study of more prolonged therapy.
A7.6 Clinical and pathological differences of elderly- and younger-onset rheumatoid arthritis in an early arthritis cohort
Authors: VC Romão, M DiCicco, A Mahto, I Lazarou, JE Fonseca, S Kelly, F Humby, C Pitzalis
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Elderly-onset rheumatoid arthritis (EORA), starting after the age of 60, is a subset of disease with different characteristics from the classic younger-onset RA (YORA). We aimed to compare clinical and pathological features between these two disease subsets in the Barts Early Arthritis Cohort (BEAC). <h3>Material and methods</h3> We included BEAC patients fulfilling ACR 2010 criteria and assessed clinical and pathological variables at baseline and at 6 months of DMARD therapy. The primary outcome was the achievement of low disease activity (LDA) according to DAS28 at 6 months. We used multivariate logistic regression to determine predictors of LDA at 6 months. <h3>Results</h3> We included 140 patients, 99 YORA and 41 EORA. EORA patients were more frequently male (51.2 vs. 26.3, p = 0.004) and Caucasian (68.3 vs. 39.4, p = 0.02), had more proximal joint involvement at presentation (55.0 vs. 35.1, p = 0.031), more common abrupt (27.5 vs. 4.1, p &lt; 0.001) and polymyalgia rheumatica (PMR)-like onset (23.7 vs. 0, p &lt; 0.001), weight loss (15.0 vs. 4.1, p = 0.026), anaemia (48.6 vs. 28.4, p = 0.033), extra-articular manifestations (27.5 vs. 6.2, p = 0.004) and cardiovascular comorbidity (73.2 vs. 29.3, p &lt; 0.001). At baseline, disease activity parameters, including ESR, CRP, joint counts, and composite scores (DAS28, CDAI and SDAI), were similar between both groups. Synovial pathotype classification (ectopic lymphoid-like structures positive (ELS+); diffuse myeloid infiltrate or non-inflammatory/pauci-immune) did not reveal differences between groups as a whole (p = 0.12). However, EORA patients presented pauci-immune pathotype less frequently (25.0 vs. 44.3, p = 0.045). Macrophage, B-cell, T-cell and plasmocyte semi-quantitative scores were also similar. At 6 months (n = 105), EORA (OR = 0.28, p = 0.047), female gender (OR = 0.23, p = 0.016), current smoking (OR = 0.11, p = 0.002) and high baseline DAS28 (OR = 0.41, p &lt; 0.001) were negatively associated with reaching DAS28 LDA. Contrastingly, PMR-like onset was strongly predictive of DAS28 LDA (OR = 63.9, p = 0.004). <h3>Conclusions</h3> In an early arthritis cohort, EORA patients presented different clinical features at presentation, but similar synovial pathological characteristics. Adjusting for other significant factors such as gender, smoking, baseline DAS28 and PMR-like onset, EORA was negatively associated with the achievement of LDA at 6 months according to DAS28.
AB0603 Serum uric acid as a predisposing factor of clinico- radiological severity of osteoarthritis knee
Authors: R. N. Srivastava, D. Sanghi, A. Mishra, A. Sharma, S. M. Natu
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Evidence suggests that uric acid involved in cartilage degeneration and other reported that it is a danger signal of increasing risk for OA through inflammasome activation and concluded that synovial uric acid is a marker of knee OA severity. feature of knee OA in Indian population. <h3>Objectives</h3> Association of serum uric acid with clinico-radiologicalfeature of knee OA in Indian population. <h3>Methods</h3> 180 ACR diagnosed OA knee patients as cases and equal number of controls were enrolled. Clinical OA outcome: pain, stiffness and functional disability were recorded by WOMAC &amp; VAS. Radiological grading was done by KL grades. In addition, four radiological features- joint space width, osteophyte, subchondral sclerosis and tibio femoralalignment were also recorded separately. S. uric acid were measured by enzymatic Uricase-Peroxidase method. <h3>Results</h3> KOA cases had significant higher BMI than controls in each group. In females, S uric acid were significantly higher in cases in comparison to controls but such association was not observed in males and in overall subjects. On analyzing uric acid with clinical features, pain was significantly associated with elevated S. uric acid in females; VAS pain alone in overall subjects but not in males. While studying the radiological features, an increasing KL grades was observed with increase in S. uric acid in overall and in both the genders separately. OA knee cases had significant higher BMI than controls in overall and in both the genders separately. In females, serum uric acid levels were significantly higher in cases in comparison to controls but such association was not observed in males and in overall subjects. Other biochemical variable like random blood sugar and total proteins were not significantly different between cases and controls in any category. On analyzing serum uric acid level with clinical features, pain (VAS and WOMAC) was significantly associated (p=0.02 and p=0.03) with elevated serum uric acid levels in females; VAS pain alone in overall study population (p=0.024) but not in males. While studying the radiological features, an increase severity of disease (increasing KL grades) was observed with increase in serum uric acid levels (KL grade 4 was 5.26 ± 1.1, KL grade 3 was 4.32 ± 0 .95 and KL grade 2 was 3.63 ± 0.95) in overall subjects and in both the genders separately. No significant association was observed for individual radiological features (IRF). <h3>Conclusions</h3> Radiological severity and knee pain was found to be significantly associated with serum uric acid levels in overall subjects and in females in OA knee. Radiological severity (KL grade) and knee pain was found to be significantly associated with serum uric acid levels in overall subjects and in females in OA knee. <h3>Disclosure of Interest</h3> None Declared
Abstract 2375: Nodal regulates the angiogenic switch in breast cancer
Authors: Daniela Quail, Guihua Zhang, Lynne-Marie Postovit
Journal: Cancer Research (2010)

Abstract Highly aggressive breast tumours undergo dedifferentiation, by displaying tissue-nonspecific gene expression patterns and stem cell-like phenotypes. Nodal is an embryonic morphogen responsible for maintaining plasticity in embryonic stem cells, and is aberrantly expressed in aggressive cancers. The current study reveals a positive correlation between Nodal and aggressive breast cancer phenotypes. Specifically, Nodal promotes self-renewal through single-cell non-adherent spheroid formation, anchorage-independent growth on soft agar, and tube formation by endothelial cells in vitro. Additionally, Nodal promotes angiogenesis in vivo. Similar to its role in embryonic morphogenesis, Nodal may be responsible for promoting the dedifferentiated phenotype of breast cancer, and subsequent angiogenic switch. Since the angiogenic switch is a precursor to metastasis, Nodal may be useful as a prognostic marker or therapeutic target for metastatic disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2375.
Abstract 2208: JNK2 regulates the <i>hif-1α</i> mRNA stability in a nucleolin-dependent manner
Authors: Dongyun Zhang, Jingxia Li, Min Zhang, Zhenghong Zuo, Yonghui Yu, Chuanshu Huang
Journal: Cancer Research (2012)

Abstract HIF-1α mRNA is regarded as constitutively and ubiquitously expressed no matter the level of oxygen tension. But most recently, more and more labs found that HIF-1α mRNA could be regulated by natural antisense transcripts, potential microRNAs, and low O2 pressure in the renal medulla in rats and in sea bass. In our current studies, we found that nucleolin, the classic histone chaperon, was able to physically bind to hif-1α mRNA and maintained its stability. Knocking down nucleolin by shRNA obviously reduced HIF-1α protein induction in response to nickel treatment resulting from the impaired expression of hif-1α mRNA. Both the promoter luciferase assay and mRNA degradation rate assay by ActD clearly showed that nucleolin knocking down did not change hif-1α transcription, but rather affected its mRNA stability. Further work found JNK2 could regulate nucleolin expression and subsequently affect its function in stabilizing hif-1α mRNA, by which we provided more evidence for the oncogenic role of JNK2 and nucleolin in regulating the cancer environments by controlling HIF-1α expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2208. doi:1538-7445.AM2012-2208