tbuckley/cabot-search huggingface dataset:
Soundings: Le Beau Doc Sans Merci
Authors: Liam Farrell
Journal: BMJ (2001)

I met a young lady in the meads. Her hair was long, her step was light; she had intended to go to medical school, she said, but she had visited the local hospital and the junior doctors had discouraged her, and she was starting dentistry instead.

I set her on my pacing steed and all day long extolled the virtues of medical life.

“Asking a junior doctor what it's like to be a doctor is like asking a tadpole what it's like to be a frog,” I said.

“Consider being able to travel all across the world, the privilege of receiving the trust of our patients, the fascinating complexity and uniqueness of every case that walks into the surgery. Consider the security of tenure, a reliable income in a volatile world. Consider the independence; once you are a GP or a consultant, you are your own boss and you don't have to suck up to nobody. Ours is a high and noble destiny, a life rich with experience, an enduring tapestry of joys and sorrows.

“We need a system of work experience for young people like you who are genuinely interested. It would be easy to determine which consultations are inappropriate for you to attend, and of course patients would be fully informed and consented. But even within these confines, it should be possible to get a taste of the real thing, and much better than learning from junior doctors or television soaps.”

The chill of icy air startled me from this reverie. We had stopped on a bleak hillside, ravens were croaking hoarsely, The Creature from the Black Lagoon was playing pinochle with an insurance salesman, and high overhead an American bomber was chucking out enough food aid to fill a small knapsack; the omens were bad. Sure enough a tin of beans plummeted down like a rocket, nearly decapitating my horse, and my student became fey and magicked. She wove a circle round me thrice, her eyes flashing, her hair floating, gratuitously acting out the wrong poem.

“La belle dame sans merci hath thee in thrall,” she exulted, then turned into a chimera, then a gorgon, then back into a girl with now rather frizzy hair before continuing, “And I'm sticking with dentistry, if you don't mind.”

“OK,” I replied, booting her off the horse, squashing a passing nut laden squirrel as she fell, “In that case you can walk home.”
Low Prevalence of Antibodies to GAD65 in a 50- to 74-Year-Old General Dutch Population: The Hoorn Study
Authors: Johannes B Ruige, Manou R Batstra, Henk-Jan Aanstoot, Lex M Bouter, G Jan Bruining, J Nico D De Neeling, Robert J Heine
Journal: Diabetes Care (1997)

OBJECTIVE To assess the prevalence of antibodies to GAD65 (GAD65-A) in relation to glucose tolerance disturbances and to blood glucose-lowering therapy in a general Dutch population. RESEARCH DESIGN AND METHODS A population sample of 2,350 Dutch subjects, age 50–74 years, agreed to undergo an oral glucose tolerance test (OGTT). They were classified as having normal glucose tolerance, impaired glucose tolerance, newly detected diabetes, or known diabetes. GAD65-A levels were measured in serum by means of a standardized radioligand assay and subsequently were expressed as indexes. The prevalence rates were defined as the proportions of individuals of each category of glucose tolerance exceeding the value of the index at the 99th percentile of the entire study population. RESULTS The prevalence rates and the 95% CIs of GAD65-A were 0.7% (0.4–1.2%) in cases of normal glucose tolerance, 2.4% (0.9–5.3%) in impaired glucose tolerance, 0% (0–3.3%) in newly detected diabetes, according to the World Health Organization (WHO) criteria, and 3.5% (0.7–10.0%) in known diabetes. A total of 2 out of 3 subjects with GAD65-A indexes above the 99th percentile and 10 out of 18 subjects with GAD65-A indexes above the 85th percentile received insulin therapy for their diabetes, which showed an association between GAD65-A and insulin therapy CONCLUSIONS Low prevalence rates of latent autoimmunity to GAD were found in 50- to 74-year-old Dutch subjects with normal and abnormal glucose tolerance, and GAD65-A was associated with insulin use in known diabetic subjects.
Health Reform and Coverage Changes Among Native Americans
Authors: Molly Frean, Shelbie Shelder, Meredith B. Rosenthal, Thomas D. Sequist, Benjamin D. Sommers
Journal: JAMA Internal Medicine (2016)

The Affordable Care Act (ACA) expands health insurance for Native Americans through Medicaid and Marketplace coverage, despite Native Americans being exempt from the law's individual mandate.The ACA also permanently reauthorized the Indian Health Care Improvement Act, which funds the Indian Health Service (IHS).The IHS provides health care services to 2.2 million Native Americans annually but is not considered insurance by the US government. 1 We evaluated changes in insurance and IHS coverage among Native Americans following the ACA's implementation.Methods | We used the 2012-2014 American Community Survey (ACS), administered by the US Census Bureau.The survey is mailed to 3.5 million households annually, with a response rate of 90% to 97%. 2 The ACS can be used to evaluate changes in health insurance in states and smaller geographic areas.
Corkscrew Esophagus
Authors: Chin Yit Soo, Jonathan Fletcher
Journal: New England Journal of Medicine (2014)

A 74-year-old man presented with a 30-year history of intermittent dysphagia and regurgitation, which his doctor had initially referred to as a “hysterical reaction.” Barium swallow showed two diverticula proximal to the marked corkscrew appearance of the distal esophagus.
Abstract 6059: Novel Helical Stent Design Elicits Swirling Blood Flow Pattern And Inhibits Neointima Formation In Porcine Carotid Arteries
Authors: Toshiro Shinke, Keith Robinson, Martin G Burke, Paul Gilson, Liam P Mullins, Norah O'Brien, Kevin B Heraty, Chas Taylor, Nicholas J Cheshire, Colin G Caro
Journal: Circulation (2008)

Background: Swirling blood flow patterns in the vasculature augments vessel wall shear stress, which in turn may, have a profound effect to suppress neointima formation. We tested whether helical-d...
Public health concerns in bat rabies across Europe
Authors: Mirjana Stantic-Pavlinic
Journal: Eurosurveillance (2005)

Rabies due to two independent and different genotypes of lyssaviruses - European bat lyssaviruses (EBLV) type 1 and type 2 - is present in many European countries. Infection is usually seen in bats, the primary reservoirs of the viruses but a few spillover infections have been seen in three other species: stone martens, sheep and humans. Spillover infections (with the exception of the two human cases) were EBLV-1 only. No EBLV-2 spillover cases have been reported in terrestrial animals. The disease is fatal in humans and has been described in Europe following a bat bite. We have studied in the available literature EBLV rabies cases across Europe in bats and humans, and have also carried out an analysis of recommendations for rabies prevention and treatments in humans. Rabies pre-exposure vaccination and post-exposure treatment is recommended for occupationally exposed persons. Some European countries have already adopted recommendations through specific protocols. Treatment of international travellers after bat bites is also recommended. The promoting of research programmes on bat rabies in Europe is underway. Bats are listed as protected species across Europe.
Should Albumin Be Considered a Prognostic Factor For Brazilian Patients Diagnosed With Classical Hodgkin Lymphoma
Authors: Guilherme Fleury Perini, Egyla M Cavalcante, Joao Garibaldi Rezende, Davimar Miranda Borducchi, Fernanda Cunha Vieira, Danielle Leao Cordeiro Faria, Renato S Tavares, Fabio Pires de Souza Santos, Nelson Hammershlack, Karin Zattar Cecyn, Eni Maria Souza, Adriana M. Damasco Penna, Otavio C.G. Baiocchi
Journal: Blood (2013)
Family expressed emotion and relapse in schizophrenia in 24 urban American patients
Authors: R A Moline, S Singh, A Morris, H Y Meltzer
Journal: American Journal of Psychiatry (1985)

The authors examined the correlation between family expressed emotion and relapse in 24 schizophrenic patients in a predominantly inner-city American setting. They found a significant correlation between relapse and high expressed emotion in family members; the level of family expressed emotion was somewhat higher than that reported in previous studies. The findings suggest that the impact of expressed emotion may vary in different sociocultural populations.
Hepatic ischemia reperfusion injury: A systematic review of literature and the role of current drugs and biomarkers
Authors: Marco Cannistrà, Michele Ruggiero, Alessandra Zullo, Giuseppe Gallelli, Simone Serafini, Mazzitelli Maria, Agostino Naso, Raffaele Grande, Raffaele Serra, Bruno Nardo
Journal: International Journal of Surgery (2016)
Back to Basics—Vital Sign and Blood Glucose Abnormalities and Outcome in Childhood Arterial Ischemic Stroke
Authors: Lauren A. Beslow
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Long-term follow-up confirms the benefit of all-trans retinoic acid in acute promyelocytic leukemia
Authors: P Fenaux, S Chevret, A Guerci, N Fegueux, H Dombret, X Thomas, M Sanz, H Link, F Maloisel, C Gardin, D Bordessoule, A-M Stoppa, A Sadoun, P Muus, H Wandt, P Mineur, JA Whittaker, M Fey, M-T Daniel, S Castaigne, L Degos
Journal: Leukemia (2000)
Best diagnostic method for floating kidney is sequential bone scintigraphy with the patient in the supine and upright positions.
Authors: WEI-JEN SHIH, KELLY GROSS
Journal: Clinical Nuclear Medicine (2001)

From the Nuclear Medicine Service, Lexington VA Medical Center, and the Nuclear Medicine Section, Department of Diagnostic Radiology, University of Kentucky Medical Center, Lexington, Kentucky Received for publication July 11, 2000. Revision accepted August 30, 2000. Correspondence: Wei-Jen Shih, M.D., Nuclear Medicine Service, Lexington VA Medical Center, Lexington, Kentucky 40511.
Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice
Authors: Yin Dou, Jiawei Guo, Yue Chen, Songling Han, Xiaoqiu Xu, Qing Shi, Yi Jia, Ya Liu, Youcai Deng, Ruibing Wang, Xiaohui Li, Jianxiang Zhang
Journal: Journal of Controlled Release (2016)
The causes of characteristic properties: Insides versus categories
Authors: Michael Strevens
Journal: Behavioral and Brain Sciences (2014)

Abstract Cimpian &amp; Salomon (C&amp;S) propose that the inherence heuristic, a tendency to explain the behavior and other properties of things in terms of their intrinsic characteristics, precedes and explains “essentialist thinking” about natural kinds. This commentary reviews evidence that it is rather essentialism (or something like it) that precedes the assumption of inherence, and suggests that essentialism can do without the inherence heuristic altogether.
Foot-and-mouth disease in man.
Authors: A Young
Journal: BMJ (1967)

MMICLJOUAL 503 possible influence of differences in smoking habits.His suggestion that "the dusty lung is in a state of enhanced immunological competence and is better able to destroy the first few cells which have undergone malignant transforma- tion than is the normal lung," though interesting, must be regarded as highly speculative.L. L. Old and his colleagues2' reported that in mice B.C.G. infection non-specifically increases resistance both to isologous tumour grafts and to the induction of cancer by 3-methylcholanthrene.However, in general, the function and importance of immune mechan- isms in relation to carcinogenesis are far from clear, and certainly in the present instance it would be wise to defer detailed consideration of possible mechanisms until the facts are more certain.
Generation of Cell Lines Harboring SETBP1 Mutations By the Crispr/Cas9 System
Authors: Nozomu Kawashima, Yusuke Okuno, Yuko Sekiya, Xinan Wang, Yinyan Xu, Atsushi Narita, Sayoko Doisaki, Michi Kamei, Hideki Muramatsu, Masahiro Irie, Asahito Hama, Yoshiyuki Takahashi, Seiji Kojima
Journal: Blood (2014)
Abstract B24: High-dimensional genomic data integration and bias correction using MANCIE
Authors: Chongzhi Zang, Tao Wang, Ke Deng, Bo Li, Sheng'en Hu, Qian Qin, Tengfei Xiao, Shihua Zhang, Clifford A. Meyer, Housheng Hansen He, Myles Brown, Jun S. Liu, Yang Xie, Xiaole Shirley Liu
Journal: Cancer Research (2016)

Abstract Most genomic and epigenomic experimental data are presented as high-dimensional matrices. Integrative analysis of such high-dimensional genomic data is challenging due to noises and biases in the high-throughput experiments from different platforms. We present MANCIE (Matrix Analysis and Normalization by Concordant Information Enhancement), a computational method for integrating two genomic datasets based on a Bayesian supported principal component analysis (PCA) approach. We demonstrate that data integration using MANCIE can reduce biases and improve the identification of tissue specificity from the Encyclopedia of DNA Elements (ENCODE) data, improve prognostic prediction from The Cancer Genome Atlas (TCGA) data, and improve the identification of genetic correlation in the Cancer Cell Line Encyclopedia (CCLE) data. MANCIE has broad applications in genomic and epigenomic data analysis in cancer research. Citation Format: Chongzhi Zang, Tao Wang, Ke Deng, Bo Li, Sheng'en Hu, Qian Qin, Tengfei Xiao, Shihua Zhang, Clifford A. Meyer, Housheng Hansen He, Myles Brown, Jun S. Liu, Yang Xie, Xiaole Shirley Liu. High-dimensional genomic data integration and bias correction using MANCIE. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr B24.
Topical fluorouracil after surgery for ocular surface squamous neoplasia in Kenya: a randomised, double-blind, placebo-controlled trial
Authors: Stephen Gichuhi, Ephantus Macharia, Joy Kabiru, Alain M'bongo Zindamoyen, Hilary Rono, Ernest Ollando, Joseph Wachira, Rhoda Munene, John Maina, Timothy Onyuma, Mandeep S Sagoo, Helen A Weiss, Matthew J Burton
Journal: The Lancet Global Health (2016)

BackgroundOcular surface squamous neoplasia (OSSN) is an aggressive eye tumour particularly affecting people with HIV in Africa. Primary treatment is surgical excision; however, tumour recurrence is common. We assessed the effect of fluorouracil 1% eye drops after surgery on recurrence.MethodsWe did this multicentre, randomised, placebo-controlled trial in four centres in Kenya. We enrolled patients with histologically proven OSSN aged at least 18 years. After standard surgical excision, participants were randomly allocated to receive either topical fluorouracil 1% or placebo four times a day for 4 weeks. Randomisation was stratified by surgeon, and participants and trial personnel were masked to assignment. Patients were followed up at 1 month, 3 months, 6 months, and 12 months. The primary outcome was clinical recurrence (supported by histological assessment where available) by 1 year, and analysed by intention to treat. The sample size was recalculated because events were more common than anticipated, and trial enrolment was stopped early. The trial was registered with Pan-African Clinical Trials Registry (PACTR201207000396219).FindingsBetween August, 2012, and July, 2014, we assigned 49 participants to fluorouracil and 49 to placebo. Four participants were lost to follow-up. Recurrences occurred in five (11%) of 47 patients in the fluorouracil group and 17 (36%) of 47 in the placebo group (odds ratio 0·21, 95% CI 0·07–0·63; p=0·01). Adjusting for passive smoking and antiretroviral therapy had little effect (odds ratio 0·23; 95% CI 0·07–0·75; p=0·02). Adverse effects occurred more commonly in the fluorouracil group, although they were transient and mild. Ocular discomfort occurred in 43 of 49 patients in the fluorouracil group versus 36 of 49 in the placebo group, epiphora occurred in 24 versus five, and eyelid skin inflammation occurred in seven versus none.InterpretationTopical fluorouracil after surgery substantially reduced recurrence of OSSN, was well-tolerated, and its use recommended.FundingBritish Council for Prevention of Blindness and the Wellcome Trust.
Families and hospitals: collusion or cooperation?
Authors: H T Harbin
Journal: American Journal of Psychiatry (1978)

The author describes the therapeutic problems that can arise on a family-oriented psychiatric inpatient service. The stress emerging from the therapeutic demands on and changes in the internal structure of the family may cause the family to seek to reestablish its internal equilibrium by changing the hospital staff and structure at the ward level, department level, and the hospital administration level. These transactions between the hospital and families, which are complex, are extremely important to recognize because they can undermine the therapeutic process.
Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation
Authors: TA Lane, P Law, M Maruyama, D Young, J Burgess, M Mullen, M Mealiffe, LW Terstappen, A Hardwick, M Moubayed
Journal: Blood (1995)
Cognitive and interactive aspects of splitting
Authors: M J Horowitz
Journal: American Journal of Psychiatry (1977)

The author discusses splitting, the segregation of multiple inner schemata of self and others, from the points of view of cognitive structure, cognitive process, anad interpersonal transaction. A case example illustrates how one borderline patient shifted fluidly during therapy among four isolated and sometimes incompatible representations of the doctor-patient relationship. The author concludes that therapists working with borderline patients must be aware of atypical transference patterns and may have to introduce, as a special nuance of therapy, work to stabilize patients' realistic self- and therapist images before offering interpretations.
Abstract B20: Malignant transformation initiates a stochastic DNA methylation alteration pattern distinct from that in senescence
Authors: Wenbing Xie, Yang W. Zhang, Li-Xia Pan, Fillipe Carvlho, Byung-Hak Kang, Limin Xia, Lauren Murphy, Cynthia A. Zahnow, Stephen B. Baylin, Hari Easwaran
Journal: Cancer Research (2016)

Abstract DNA methylation changes are a hallmark of cancers and occur during early tumorigenesis stages. Also, distinct DNA methylation patterns are reported to be characteristic of the anti-tumorigenic process of cell senescence. It is hypothesized that some cells escape senescence and retain the DNA methylation abnormalities manifest in cancers. We now re-visit, in a classic model of tumor progression in human fibroblasts, the relationships between genome-wide DNA methylation patterns associated with senescence, immortalization and transformation. We find that although DNA methylation alterations are a key feature during senescence, these changes are distinct from those we now find associated with malignant transformation in our model and which are classically seen in cancer. Both DNA methylation gains, predominantly at promoter CpG islands, and more balanced losses and gains at other loci, are seen by the time of pre-senescence and remain relatively stable until full senescence is reached. These DNA methylation alterations follow a reproducible pattern amongst independent senescent replicates involving genes in biological processes which positively regulate biosynthesis, gene transcription and macromolecule metabolism. In contrast, during immortalization and malignant transformation, the DNA methylation alterations appear to arise in a stochastic process resulting in heterogeneous methylation patterns amongst independently immortalized and transformed replicates. Gene ontology analysis shows that genes which gain DNA methylation in normally unmethylated promoter CpG island regions in independent transformation replicates enrich for functions involved in developmental regulation. Over the course of progression from immortalization to the transformed state in our model, gene promoter CpG island hypermethylation frequency increases, as does the numbers of associated genes that have decreased gene expression. Thus, a hallmark of the early transformation process is a stochastic accumulation of DNA methylation changes, distinct from those occurring during senescence, that converges to increasingly affect developmental biological processes and diminished transcription of many of the involved genes, which may help drive the process of tumor progression. Citation Format: Wenbing Xie, Yang W. Zhang, Li-Xia Pan, Fillipe Carvlho, Byung-Hak Kang, Limin Xia, Lauren Murphy, Cynthia A. Zahnow, Stephen B. Baylin, Hari Easwaran. Malignant transformation initiates a stochastic DNA methylation alteration pattern distinct from that in senescence. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr B20.
Application of Novel Next Generation Sequencing Gene Panel Assay to Genetic and Clinical Diagnosis of Inherited Bone Marrow Failure Syndromes
Authors: Ibrahim Ghemlas, Hongbing Li, Bozana Zlateska, Robert J. Klaassen, Conrad V Fernandez, Rochelle Yanofsky, John K. Wu, Yves Pastore, Mariana Silva, Jeffrey H. Lipton, Josse Brossard, Michon Bruno, Sharon Abish, MacGregor Steele, Roona Sinha, Mark J. Belletrutti, Vicky R Breakey, Lawrence Jardine, Lisa Goodyear, Lillian Sung, Santhosh Dhanraj, Emma Reble, Amanda Wagner, Joseph Beyene, Peter Ray, Stephen Meyn, Michaela Cada, Yigal Dror
Journal: Blood (2014)
Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects
Authors: E F Coccaro, R J Kavoussi, T B Cooper, R L Hauger
Journal: American Journal of Psychiatry (1997)

This study compared the nature and magnitude of the relationship between aggression and CSF 5-hydroxyindoleacetic acid (5-HIAA) concentration with that between aggression and the prolactin response to d-fenfluramine challenge in human subjects.The Life History of Aggression assessment scores of 24 subjects with personality disorders were compared with their lumbar CSF 5-HIAA concentrations and with their prolactin responses to d-fenfluramine challenge.Aggression was significantly and inversely correlated with prolactin responses to d-fenfluramine challenge but not with lumbar CSF 5-HIAA concentrations in these subjects.Prolactin response to d-fenfluramine may be more sensitive than lumbar CSF 5-HIAA concentration in detecting a relationship between aggression and central serotonin activity in noncriminally violent human subjects.