tbuckley/cabot-search huggingface dataset:
Integrated post-surgical colon cancer care planning at the Rutgers Cancer Institute of New Jersey and Robert Wood Johnson University Hospital.
Authors: Teresa V. Brown, Kristen Donohue, Sondra Patella, Viktor Y. Dombrovskiy, Rebecca Anne Moss, Nell Maloney Patel
Journal: Journal of Clinical Oncology (2016)

75 Background: Colorectal cancer is the second leading cause of cancer death in the United States each year. The use of adjuvant chemotherapy after surgical resection of colon cancer has been associated with a survival benefit. Timely initiation of adjuvant chemotherapy has been shown to have an effect on overall and disease-free survival. There is no integrated post-surgical colon cancer care planning for patients who have surgery at our institution. Poor understanding on the part of patients and ancillary providers regarding appropriate follow up may cause delay in time to adjuvant chemotherapy initiation. Methods: Baseline data was obtained for the ASCO Quality Training Program. Chart review was conducted on patients with stage III colorectal cancer that were treated at the Cancer Institute of New Jersey and Robert Wood Johnson University Hospital to identify average time to adjuvant chemotherapy initiation and factors which were thought to have a strong influence on chemotherapy initiation. Time to initiation of adjuvant chemotherapy, pathology report resulting, central access obtainment, and outpatient medical oncology appointment was abstracted from patient charts. Other factors including the presence of intraoperative or postoperative complications, type of surgeon, academic versus private medical oncologist, and the presence of an inpatient medical oncology consult were also identified and reviewed. Results: 128 patient charts were reviewed. Mean number of days from surgery to adjuvant chemotherapy (n = 79) was 49.6, to pathology report resulting (n = 70) was 4.92, to central access obtainment (n = 49) was 40, and to outpatient medical oncology appointment (n = 38) was 30. The presence of intraoperative (p &lt; 0.059) and postoperative complications (p &lt; 0.0155) was found to have a statistically significant effect on time to initiation of adjuvant chemotherapy. Conclusions: While there are some uncontrollable factors like operative complications that delay time to initiation of chemotherapy, engaging the patient may help decrease the time to adjuvant chemotherapy by increasing patient awareness of the importance of seeking aggressive postoperative care.
Late-stage lung cancer patient preferences about chemotherapy treatment adverse side effects.
Authors: K. M Islam, June Ryan, Ann Fetrick, Apar Kishor Ganti
Journal: Journal of Clinical Oncology (2016)

93 Background: Patients’ preferences regarding treatment adverse events are not systematically considered when choosing a treatment for stage lung cancer. Further, there is no clinical guide for patients or physicians on how to integrate patient preferences of adverse events in treatment and care decisions. Although it is assumed that most cancer patients prefer either an active or a shared role in decision making, particularly in late stage cancers. Our specific aim of this abstract is: Aim: Determine whether individual patients’ preferences, characteristics, and treatment experiences affect the meaning of chemotherapy treatment success. Methods: We have completed two years of our three-year research using a mixed method study design, which includes focus groups, cross-sectional, prospective, and randomized experimental designs. We initially selected three cancer centers in Nebraska and one in South Dakota for patient and provider recruitment. Currently, we have six cancer centers participating in this multi-center Patient Centered Outcomes Research. Results: Four focus groups were conducted with 36 participants that included patients, family members and caregivers and oncology providers. Patients and caregivers confirmed that survival alone is not their measure of lung cancer treatment success Definition of treatment success should emphasize effective clinical guidance throughout treatment, symptom management, functionality, and quality of life Definition of treatment success evolves over time, appearing to be linked to patients’ experiences with chemotherapy. Participants advocated for better patient-provider communication practices as well as the expanded use of patient navigation and new patient orientation programs. Conclusions: Late stage lung cancer patients have definite opinions about the impact of adverse treatment effects on their quality of life.
Long-Term Exposure to Pomalidomide-Dexamethasone in Pts with Refractory Myeloma
Authors: Brigitte Pegourie, Marie Odile Petillon, Lionel Karlin, Denis Caillot, Murielle Roussel, Bertrand Arnulf, Claire Mathiot, Gerald Marit, Margaret Macro, Brigitte Kolb, Anne-Marie Stoppa, Sabine Brechiniac, Laurent Garderet, Bruno Royer, Cyril Hulin, Lotfi B Benbouker, Olivier Decaux, Martine Escoffre-Barbe, Jean Paul Fermand, Philippe Moreau, Hervé Avet-Loiseau, Michel Attal, Thierry Facon, Xavier Leleu
Journal: Blood (2014)
Cardiac Memory in Patients With Wolff-Parkinson-White Syndrome
Authors: Subham Ghosh, Edward K. Rhee, Jennifer N. Avari, Pamela K. Woodard, Yoram Rudy
Journal: Circulation (2008)

Cardiac memory refers to a change in ventricular repolarization induced by and persisting for minutes to months after cessation of a period of altered ventricular activation (eg, resulting from pacing or preexcitation in patients with Wolff-Parkinson-White syndrome). ECG imaging (ECGI) is a novel imaging modality for noninvasive electroanatomic mapping of epicardial activation and repolarization.Fourteen pediatric patients with Wolff-Parkinson-White syndrome and no other congenital disease, were imaged with ECGI a day before and 45 minutes, 1 week, and 1 month after successful catheter ablation. ECGI determined that preexcitation sites were consistent with sites of successful ablation in all cases to within a 1-hour arc of each atrioventricular annulus. In the preexcited rhythm, activation-recovery interval (ARI) was the longest (349+/-6 ms) in the area of preexcitation leading to high average base-to-apex ARI dispersion of 95+/-9 ms (normal is approximately 40 ms). The ARI dispersion remained the same 45 minutes after ablation, although the activation sequence was restored to normal. ARI dispersion was still high (79+/-9 ms) 1 week later and returned to normal (45+/-6 ms) 1 month after ablation.The study demonstrates that ECGI can noninvasively localize ventricular insertion sites of accessory pathways to guide ablation and evaluate its outcome in pediatric patients with Wolff-Parkinson-White syndrome. Wolff-Parkinson-White is associated with high ARI dispersion in the preexcited rhythm that persists after ablation and gradually returns to normal over a period of 1 month, demonstrating the presence of cardiac memory. The 1-month time course is consistent with transcriptional reprogramming and remodeling of ion channels.
Prenatal PBDE and PCB Exposures and Reading, Cognition, and Externalizing Behavior in Children
Authors: Hongmei Zhang, Kimberly Yolton, Glenys M. Webster, Andreas Sjödin, Antonia M. Calafat, Kim N. Dietrich, Yingying Xu, Changchun Xie, Joseph M. Braun, Bruce P. Lanphear, Aimin Chen
Journal: Environmental Health Perspectives (2016)

Background:Prenatal polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) exposures may influence children's neurodevelopment.Objective:We examined the association of prenatal PBDE and PCB exposures with children's reading skills at ages 5 and 8 years, Full-Scale Intelligence Quotient (FSIQ), and externalizing behavior problems at age 8 years.Methods:From 239 mother–child pairs recruited (2003–2006) in Cincinnati, Ohio, we measured maternal serum PBDE and PCB concentrations, assessed child's reading skills using the Woodcock–Johnson Tests of Achievement III (WJ-III) at age 5 years and the Wide Range Achievement Test-4 (WRAT-4) at age 8 years, tested FSIQ using the Wechsler Intelligence Scale for Children-IV (WISC-IV), and externalizing behavior problems using the Behavioral Assessment System for Children-2 (BASC-2) at age 8 years. We used multiple linear regression to examine the association of prenatal PBDE and PCB concentrations and reading, FSIQ, and externalizing behavior problems after adjusting for covariates.Results:An increase of Sum4PBDEs (BDE-47, BDE-99, BDE-100, and BDE-153) by 10 times was not significantly associated with reading scores at age 5 years at the p = 0.05 level but was inversely associated with Reading Composite scores (β: –6.2, 95% CI: –11.7, –0.6) and FSIQ (β: –5.3, 95% CI: –10.6, –0.02) at age 8 years; it was positively associated with the score for externalizing behavior problems (β: 3.5, 95% CI: –0.1, 7.2) at age 8 years. Prenatal Sum4PCBs (PCB-118, -153, -138-158, and -180) was not significantly associated with a child's reading skills, FSIQ, and externalizing behavior problems.Conclusion:Prenatal PBDE concentration was inversely associated with reading skills and FSIQ and positively associated with externalizing behavior problems at age 8 years. No significant associations were found in prenatal PCB concentration.Citation:Zhang H, Yolton K, Webster GM, Sjödin A, Calafat AM, Dietrich KN, Xu Y, Xie C, Braun JM, Lanphear BP, Chen A. 2017. Prenatal PBDE and PCB exposures and reading, cognition, and externalizing behavior in children. Environ Health Perspect 125:746–752; http://dx.doi.org/10.1289/EHP478
Characteristics, outcome, and response to therapy of multirefractory chronic immune thrombocytopenia
Authors: Matthieu Mahévas, Mathieu Gerfaud-Valentin, Guillaume Moulis, Louis Terriou, Sylvain Audia, Sophie Guenin, Guillaume Le Guenno, Gilles Salles, Olivier Lambotte, Nicolas Limal, Jean-François Viallard, Stephane Cheze, Cecile Tomowiak, Bruno Royer, Antoine Neel, Odile Debouverie, Arnaud Hot, Isabelle Durieu, Antoinette Perlat, Manuel Cliquennois, Clémence Deteix, Marc Michel, Bertrand Godeau
Journal: Blood (2016)
Surface modifications of PEOT/PBT copolymers for the improvement of bone marrow stromal cell attachment
Authors: J. Prof. dr. Feijen, M.B. Claase, A.P. Dr. Sam, M.B. Olde riekerink, Dirk W. Grijpma, Jan Feijen, S.C. Mendes, Joost Dick de Bruijn
Journal: Journal of Controlled Release (2002)
Tissue Engineering: Toward a New Era of Medicine
Authors: Ashkan Shafiee, Anthony Atala
Journal: Annual Review of Medicine (2016)

The goal of tissue engineering is to mitigate the critical shortage of donor organs via in vitro fabrication of functional biological structures. Tissue engineering is one of the most prominent examples of interdisciplinary fields, where scientists with different backgrounds work together to boost the quality of life by addressing critical health issues. Many different fields, such as developmental and molecular biology, as well as technologies, such as micro- and nanotechnologies and additive manufacturing, have been integral for advancing the field of tissue engineering. Over the past 20 years, spectacular advancements have been achieved to harness nature's ability to cure diseased tissues and organs. Patients have received laboratory-grown tissues and organs made out of their own cells, thus eliminating the risk of rejection. However, challenges remain when addressing more complex solid organs such as the heart, liver, and kidney. Herein, we review recent accomplishments as well as challenges that must be addressed in the field of tissue engineering and provide a perspective regarding strategies in further development.
RARγ Downregulation Contributes to Colorectal Tumorigenesis and Metastasis by Derepressing the Hippo–Yap Pathway
Authors: Peng-Da Guo, Xing-Xing Lu, Wen-Juan Gan, Xiu-Ming Li, Xiao-Shun He, Shen Zhang, Qing-Hua Ji, Feng Zhou, Yue Cao, Jing-Ru Wang, Jian-Ming Li, Hua Wu
Journal: Cancer Research (2016)

Abstract The Hippo–Yap pathway conveys oncogenic signals, but its regulation during cancer development is not well understood. Here, we identify the nuclear receptor RARγ as a regulator of the Hippo–Yap pathway in colorectal tumorigenesis and metastasis. RARγ is downregulated in human colorectal cancer tissues, where its expression correlates inversely with tumor size, TNM stage, and distant metastasis. Functional studies established that silencing of RARγ drove colorectal cancer cell growth, invasion, and metastatic properties both in vitro and in vivo. Mechanistically, RARγ controlled Hippo–Yap signaling to inhibit colorectal cancer development, acting to promote phosphorylation and binding of Lats1 to its transcriptional coactivator Yap and thereby inactivating Yap target gene expression. In clinical specimens, RARγ expression correlated with overall survival outcomes and expression of critical Hippo–Yap pathway effector molecules in colorectal cancer patients. Collectively, our results defined RARγ as tumor suppressor in colorectal cancer that acts by restricting oncogenic signaling by the Hippo–Yap pathway, with potential implications for new approaches to colorectal cancer therapy. Cancer Res; 76(13); 3813–25. ©2016 AACR.
Hypertension associated with oral administration of physostigmine in a patient with Alzheimer's disease
Authors: J W Cain
Journal: American Journal of Psychiatry (1986)

The hemodynamic effects of physostigmine, a cholinomimetic drug used in the experimental treatment of Alzheimer's disease, are largely unknown. The author describes the development of episodes of hypertension in an elderly patient with Alzheimer's disease following treatment with oral physostigmine.
Asian tiger mosquito (Aedes albopictus) - a threat for Switzerland?
Authors: M N Wymann, E Flacio, S Radczuweit, N Patocchi, P Lüthy
Journal: Eurosurveillance (2008)

The Asian tiger mosquito, Aedes albopictus (Stegomya albopicta) originating from south-east Asia, has spread primarily by the trade of used tyres to the United States, Europe, Latin America and Africa [1]. In Italy, the mosquito species was first detected in Genoa in 1990 and has since spread to several parts of the country, including border areas with Switzerland [2]. In 2000, an active monitoring system was established in southern Switzerland. The first tiger mosquito was detected in the canton of Ticino in 2003 [3]. Monitoring was gradually intensified due to growing mosquito densities in northern Italy. As the long-distance migration of Ae. albopictus depends on passive transport, the monitoring system consisted of strategically positioned oviposition traps along main traffic axes, including parking lots within industrial complexes, border crossings and shopping centres. In 2007, this monitoring system consisted of over 70 checkpoints with a total of 300 traps. Bi-weekly control visits to all traps were conducted between April and November 2007. As soon as eggs were detected, the surrounding vegetation within a perimeter of about 100 metres was sprayed with permethrin against adult mosquitoes. Stagnant water was treated with Bacillus thuringiensis and in some cases with diflubenzuron to control the larval stages.
Aneurysm Guidelines
Authors: Rebecca Voelker
Journal: JAMA (2000)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Female Genital Mutilation Continues in Guinea
Authors: M. J. Friedrich
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Thiocyanate Blocks Peroxidase-Dependent Extracellular Trap (ET) Formation By PMN and Eosinophils: Heme Is a Potent New Agonist For The ET Pathway
Authors: Kristin Mathson, Rehani Teena, John D Belcher, Gregory M Vercellotti, Arne Slungaard
Journal: Blood (2013)
426PD Efficacy by blind independent central review (BICR): Post hoc analyses of the phase III, multicentre, randomised IPASS study of 1st-line gefitinib (G) vs carboplatin/paclitaxel (C/P) in Asian patients (pts) with EGFR mutation-positive advanced NSCLC
Authors: T. Mok, N. Saijo, S. Thongprasert, J.C.-H. Yang, Y.-L. Wu, H. Young, V. Haddad, H. Jiang, M. Fukuoka
Journal: Annals of Oncology (2015)
PD-019 ARQ 087, an oral pan- fibroblast growth factor receptor (FGFR) inhibitor, in patients (pts) with advanced and/or metastatic intrahepatic cholangiocarcinoma (iCCA)
Authors: V. Mazzaferro, W. Shaib, L. Rimassa, W. Harris, N. Personeni, B. El-Rayes, A. Tolcher, T. Hall, Y. Wang, B. Schwartz, J. Kazakin, M. Droz Dit Busset, C. Cotsoglou, K. Papadopoulos
Journal: Annals of Oncology (2016)
Association Between the Safe Delivery App and Quality of Care and Perinatal Survival in Ethiopia
Authors: Stine Lund, Ida Marie Boas, Tariku Bedesa, Wondewossen Fekede, Henriette Svarre Nielsen, Bjarke Lund Sørensen
Journal: JAMA Pediatrics (2016)

Health apps in low-income countries are emerging tools with the potential to improve quality of health care services, but few apps undergo rigorous scientific evaluation.To determine the effects of the safe delivery app (SDA) on perinatal survival and on health care workers' knowledge and skills in neonatal resuscitation.In a cluster-randomized clinical trial in 5 rural districts of Ethiopia, 73 health care facilities were randomized to the mobile phone intervention or to standard care (control). From September 1, 2013, to February 1, 2015, 3601 women in active labor were included at admission and followed up until 7 days after delivery to record perinatal mortality. Knowledge and skills in neonatal resuscitation were assessed at baseline and at 6 and 12 months after the intervention among 176 health care workers at the included facilities. Analyses were performed based on the intention-to-treat principle.Health care workers in intervention facilities received a smartphone with the SDA. The SDA is a training tool in emergency obstetric and neonatal care that uses visual guidance in animated videos with clinical instructions for management.The primary outcome was perinatal death. Secondary outcomes included the knowledge and clinical management of neonatal resuscitation (skills) of health care workers before the intervention and after 6 and 12 months.The analysis included 3601 women and 176 health care workers. Use of the SDA was associated with a nonsignificant lower perinatal mortality of 14 per 1000 births in intervention clusters compared with 23 per 1000 births in control clusters (odds ratio, 0.76; 95% CI, 0.32-1.81). The skill scores of intervention health care workers increased significantly compared with those of controls at 6 months (mean difference, 6.04; 95% CI, 4.26-7.82) and 12 months (mean difference, 8.79; 95% CI, 7.14-10.45) from baseline, corresponding to 80% and 107%, respectively, above the control level. Knowledge scores also significantly improved in the intervention compared with the control group at 6 months (mean difference, 1.67; 95% CI, 1.02-2.32) and at 12 months (mean difference, 1.54; 95% CI, 0.98-2.09), corresponding to 39% and 38%, respectively, above the control level.The SDA was an effective method to improve and sustain the health care workers' knowledge and skills in neonatal resuscitation as long as 12 months after introduction. Perinatal mortality was nonsignificantly reduced after the intervention. The results are highly relevant in low-income countries, where quality of care is challenged by a lack of continuing education.clinicaltrials.gov Identifier: NCT01945931.
Sensory experiences during treatment of phobias by in vivo exposure
Authors: G C Curtis
Journal: American Journal of Psychiatry (1981)

The author describes several patients undergoing in vivo exposure therapy for simple phobias who reported transient sensory distortions without other evidence of psychosis. The experiences occurred mainly in the tactile, kinesthetic, and visual modes. Their nature and significance are undetermined, but they appear to resemble conversion symptoms, hypnotic sensory distortions, and other nonpsychotic sensory experiences stimulated by emotionally charged ideas.
BMA annual meeting: GMC should be funded by public not doctors, says BMA
Authors: Abi Rimmer
Journal: BMJ (2016)

The BMA has called for the General Medical Council to be funded from the public purse rather than by doctors.

Delegates at the BMA’s annual representatives meeting in Belfast on Tuesday 21 June voted in favour of a motion calling for the association to “support a move to shift funding” to the public.

Proposing the motion, Rajiv Kumar, from the BMA’s Staff Associate Specialists and Specialty Doctors Committee, pointed out that most complaints received by the GMC were made by patients.

“These [complaints] are the least likely to go to a formal hearing, but they do result in devastation and even deaths for the doctors involved,” Kumar said. “The GMC judges us guilty until proven innocent. What a travesty,” he …
Lenalidomide plus dexamethasone versus observation in patients with high-risk smouldering multiple myeloma (QuiRedex): long-term follow-up of a randomised, controlled, phase 3 trial
Authors: María-Victoria Mateos, Miguel-Teodoro Hernández, Pilar Giraldo, Javier de la Rubia, Felipe de Arriba, Lucía López Corral, Laura Rosiñol, Bruno Paiva, Luis Palomera, Joan Bargay, Albert Oriol, Felipe Prosper, Javier López, José-María Arguiñano, Nuria Quintana, José-Luis García, Joan Bladé, Juan-José Lahuerta, Jesús-F San Miguel
Journal: The Lancet Oncology (2016)
Unrelated Umbilical Cord Blood Transplantation: Characteristics and Outcomes In Older Patients With Hematological Malignancies In Europe and United States: A Eurocord/European Group For Blood and Marrow Transplantation (EBMT) and Center For International Blood and Marrow Transplant Research (CIBMTR) Study
Authors: Annalisa Ruggeri, Mary Eapen, Fernanda Volt, Chantal Kenzey, Federica Giannotti, Erick Xavier, Mary M. Horowitz, Vanderson Rocha, Daniel J. Weisdorf, Eliane Gluckman
Journal: Blood (2013)