tbuckley/cabot-search huggingface dataset:
Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome
Authors: S Puzelli, M Facchini, M A De Marco, A Palmieri, D Spagnolo, S Boros, F Corcioli, D Trotta, P Bagnarelli, A Azzi, A Cassone, G Rezza, M G Pompa, F Oleari, I Donatelli, None the Influnet Surveillance Group for
Journal: Eurosurveillance (2010)

Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222.
Abstract IA13: Myc, metabolism, and cancer.
Authors: Chi Van Dang.
Journal: Clinical Cancer Research (2016)

Abstract The MYC oncogene is highly amplified in many human cancers, and importantly is frequently amplified in ovarian cancer. It encodes a helix-loop-helix transcription factor, Myc, that dimerizes with a partner, Max, to bind the DNA consensus E-box sequence and broadly affects transcription by alleviating RNA polymerase pausing. Myc activates hundreds to thousands of genes that involve ribosome biogenesis, metabolism, and cell cycle control. Its deregulated expression in cancer cells causes a constitutive drive for cell growth, thereby rendering MYC-overexpressing cells addicted to specific metabolic pathways that may be dependent on the mutational spectrum of the cancer cell. For example, loss of p53 in combination with deregulated MYC, relieve cells from apoptotic pressure and unleash MYC's full potential as an oncogenic transcription factor. The dependence of MYC-overexpressing cells on nutrients provide a synthetic lethal approach to target metabolism for therapy. Further, deregulated MYC disrupt the circadian clock and metabolism in favor of cell growth-related metabolism. Hence, timing of metabolic therapies for MYC-induced cancers such as ovarian cancer may provide a new therapeutic window for emerging metabolic therapies. Note: This abstract was not presented at the conference. Citation Format: Chi Van Dang. Myc, metabolism, and cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr IA13.
Antiemetic effect of high-dose metoclopramide.
Authors: F Roila, M Tonato, A Del Favero, E Ballatori
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.3.440 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3950680 Antiemetic effect of high-dose metoclopramide. F RoilaxF RoilaSearch for articles by this author , M TonatoxM TonatoSearch for articles by this author , A Del FaveroxA Del FaveroSearch for articles by this author , E BallatorixE BallatoriSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.3.440 PDF "Antiemetic effect of high-dose metoclopramide.." Journal of Clinical Oncology, 4(3), pp. 440–441© 1986 by American Society of Clinical Oncology
Immunosuppressive Therapy
Authors: Mary D. Skinner, Robert S. Schwartz
Journal: New England Journal of Medicine (1972)

IMMUNOSUPPRESSIVE therapy has had a dramatic influence on the field of organ transplantation, and today, a dozen years after the discovery of the immunosuppressive properties of the antipurines, the transplantation of kidneys is an accepted and widely practiced form of treatment. By contrast, immunosuppressive agents have thus far failed to revolutionize the treatment of immunologic diseases. Drugs of this type are used in immunologic disorders with the expectation that they will inhibit the production of pathogenetic antibodies or suppress the inflammatory responses provoked by antigen–antibody reactions. But since the etiology and pathogenesis of most of these . . .
Visions for the next five years: ECDC as a sustainable and service-oriented organisation
Authors: M Sprenger
Journal: Eurosurveillance (2010)

Preview this article: Visions for the next five years: ECDC as a sustainable and service-oriented organisation, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/19/art19564-en-1.gif
Are there clinical differences between familial and nonfamilial Alzheimer's disease?
Authors: D J Luchins, D Cohen, P Hanrahan, C Eisdorfer, G Paveza, J W Ashford, P Gorelick, R Hirschman, S Freels, P Levy
Journal: American Journal of Psychiatry (1992)

The purpose of the study was to determine whether there are differences in clinical characteristics in two groups of patients with Alzheimer's disease, those reported to have a family history of dementia and those without a family history of dementia.Using a data set from an Alzheimer's disease patient registry, funded as part of a National Institute on Aging cooperative agreement, the authors made comparisons of sociodemographic and clinical variables in a group of 462 patients with Alzheimer's disease, 172 reported to have at least one first-degree relative with dementia and 290 classified with no family history.Patients with a presumptive family history differed from those without a family history in two ways: the course of dementia was described as having a fast rather than a slow progression from onset of symptoms to diagnosis, and caregivers reported a higher prevalence of family history of psychiatric disorders. There were no significant differences in age at onset, duration, female gender, aphasia and apraxia, handedness, family history of Down's syndrome, or number of children, brothers, and sisters.The association of faster course and family history of psychiatric disorders in the patients with a family history of dementia is consistent with the hypothesis of heterogeneity, but the overall results could also be explained by a genetic-environmental model of Alzheimer's disease.
Self-Pathologizing and the Perception of Necessity: Two Major Risks of Providing Stimulants to Educationally Underprivileged Students
Authors: Christine Stevenson
Journal: The American Journal of Bioethics (2016)

Keisha Ray (2016) tackles one of the foremost objections to a policy of offering stimulant pharmaceuticals to socially disadvantaged students: that such a policy attributes pathology to these stude...
Follow-up of depressed women after maintenance treatment
Authors: M M Weissman, S V Kasl, G L Klerman
Journal: American Journal of Psychiatry (1976)

The authors present follow-up results based on 150 women 1 year after maintenance treatment for depression. Maintenance treatment consisted of 8 months of amitriptyline, psychotherapy, or a combination of the two, administered by random assignment following recovery from an acute depressive episode. Approximately 30% of the patients remained in complete remission, 60% experienced recurrence of symptoms, and 12% remained mildly but chronically symptomatic. The implications of these findings for planning care for the ambulatory depressed patient on both an individual and a public health basis are discussed.
Acute Suppurative Parotitis
Authors: J D Bybee
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Biochemistry of Parkinson's Disease
Authors: T Nagatsu
Journal: JAMA (1963)

Several genes have been identified for monogenic disorders that variably resemble Parkinson's disease.Dominant mutations in the gene encoding α-synuclein enhance the propensity of this protein to aggregate.As a consequence, these patients have a widespread disease with protein inclusion bodies in several brain areas.In contrast, mutations in several recessive genes ( parkin, DJ-1, and PINK1) produce neuronal cell loss but generally without protein aggregation pathology.Progress has been made in understanding some of the mechanisms of toxicity: Parkin is an E3 ubiquitin ligase and DJ-1 and PINK1 appear to protect against mitochondrial damage.However, we have not yet fully resolved how the recessive genes relate to α-synuclein, or whether they represent different ways to induce a similar phenotype.
A Study of Abt-767 in Advanced Solid Tumors with Brca 1 and Brca 2 Mutations and High Grade Serous Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Authors: M.J.A. de Jonge, C. van Herpen, J.A. Gietema, S. Shepherd, R. Koornstra, A. Jager, M. n De Hollander, M. Dunbar, R. Hetman, C. Serpenti, H. Xiong, M. Zhu, V.L. Giranda
Journal: Annals of Oncology (2014)
Benign tremulous Parkinsonism: a unique entity or another facet of Parkinson’s disease?
Authors: Wissam Deeb, Wei Hu, Leonardo Almeida, Addie Patterson, Daniel Martinez-Ramirez, Aparna Wagle Shukla
Journal: Translational Neurodegeneration (2016)

Benign tremulous parkinsonism (BTP) is characterized by a prominent tremor that occurs both at rest and with action in conjunction with other mild features of parkinsonism. The progression of symptoms is typically slow and there is often a positive family history. Although BTP is included within the phenotypic spectrum of Parkinsonism its exact relationship with idiopathic Parkinson's disease remains unclear. Treatment of BTP is challenging especially considering the poor response to levodopa, therefore surgical therapies such as deep brain stimulation surgery are sought for treatment of these tremors. In this review, we will summarize the clinical features, diagnosis, neuropathology and treatment for BTP.
Spontaneous Colon Tumors in Rats 2
Authors: Masanao Miwa, Shinji Takenaka, Kikuji Ito, Kosaku Fujiwara, Kikuko Kogure, Akira Tokunaga, Motoo Hozumi, Shinji Fujimura, Takashi Sugimura
Journal: JNCI Journal of the National Cancer Institute (1976)

Twenty-eight cases of spontaneous colon tumors were found during autopsy of approximately 3,000 male W rats in our laboratories between 1968 and 1974. Macroscopically, these tumors were multiple and localized in the proximal part of the colon. Many nodules protruded on the serosal surface; polypoid tumors protruding into the lumen were rare. Microscopically, hyperplastic and adenomatous polyps were observed in the mucous membrane of the colon. There was adenomatous downward growth into the submucosal layer, and tubular-type adenocarcinomas invaded all the coats of the colon wall. Structural atypism was frequent and slight cell atypism was also present. Invasive tumors sometimes had an inflammatory reaction, and bacterial growth was observed within the neoplastic glands in thionine-stained sections. Escherichia coli and a gram-negative, facultative anaerobic bacillus, which grew only with E. coli in vitro, were isolated. A cultured epithelial cell line was established from one colon tumor. After a primary tumor was transplanted intraperitoneally into young adult rats, a mass grew in the peritoneal cavity for 4 months. The tumor incidence seemed higher at different times in the animals examined.
&lt;emph type="ital"&gt;Self-portrait&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prognostic Significance of Tumour-Associated Immune Response Gene Expression, Esr1 and Clinicopathologic Parameters in Stage Ii/Iii Colorectal Cancer: a Translational Research Study of the Hellenic Cooperative Oncology Group (Hecog)
Authors: G. Pentheroudakis, V. Kotoula, G. Raptou, V. Karavasilis, G. Gourioti, C. Papandreou, K.N. Syrigos, E. Bournakis, G. Rallis, I. Varthalitis, E. Galani, G. Lazaridis, G. Papaxoinis, D.G. Pectasides, G. Aravantinos, K.T. Kalogeras, T. Makatsoris, R. Wirtz, G. Fountzilas
Journal: Annals of Oncology (2014)
Abstract P2-12-13: Modified pectoral nerves block for postoperative analgesia after modified radical mastectomy: A comparative study
Authors: R Kanitkar, A Mane, A Agashe, M Kulkarni, S Deshmukh
Journal: Cancer Research (2016)

Abstract Background: The modified pectoral nerves block (Pecs II) as a method of analgesia for breast cancer surgery has shown excellent results in recent publications. This technique blocks the long thoracic nerve, thoracic intercostal nerves from T2-T6 &amp; thoracodorsal nerve. Aims: To evaluate the effectiveness of the Pecs II block for pain relief in the postoperative period of patients undergoing modified radical mastectomy (MRM). Methods: A prospective comparative study was conducted at our instituition between November 2014 and March 2015. Patients scheduled to undergo MRM were randomly assigned to the test group (endotracheal anaesthesia along with Pecs II) and the control group (endotracheal anaesthesia only). In the postoperative period the patients were evaluated using a visual analogue scale to determine pain scores at 6, 12 &amp; 24 hours. Results: Fifty patients (25 in each group), between the ages of 24 to 76 years (54.76 ± 10) were included in the study. There was no significant difference in ages between test &amp; control groups. In the postoperative period, the test group had significantly lower median pain scores at 6, 12 &amp; 24 hours as compared to the control group. Table 1: Comparative analysis for Pecs II block TestControlp valueeffect size (r)Average age (years)54.44 ± 10.7855.08 ± 9.370.824-Median postoperative pain scores 6 hours2 (1)6 (2)&amp;lt;0.001*- 0.8312 hours3 (1)5 (2)&amp;lt;0.001*- 0.6224 hours3 (1)0.034*- 0.30* statistically significant Conclusion: The modified pectoral nerves block (Pecs II) is a novel &amp; effective technique for postoperative analgesia in patients undergoing modified radical mastectomy. Citation Format: Kanitkar R, Mane A, Agashe A, Kulkarni M, Deshmukh S. Modified pectoral nerves block for postoperative analgesia after modified radical mastectomy: A comparative study. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-12-13.
Abstract IA12: Determinants of resistance and response in high-grade serous ovarian cancer.
Authors: David D. L. Bowtell
Journal: Clinical Cancer Research (2016)

Abstract In contrast to other solid cancers, overall survival for patients with high-grade serous ovarian cancer (HGSC) is little changed over the last 30 years and it has been difficult to advance beyond platinum-based combination chemotherapy. As HGSC are driven by genomic copy number change rather than recurrent point mutation, we undertook whole genome sequence (WGS) analysis of a large HGSC cohort in order to survey structural variation at high resolution. Utilizing 114 tumors from 92 patients, we performed transcriptome, methylation, and miRNA expression analyses to support the WGS data, and compared resistant, refractory, and sensitive primary disease. We evaluated tumor and normal DNA samples from patients with primary refractory, primary resistant or primary sensitive disease to better understand the drivers of these clinical phenotypes. We also characterized paired pre-treatment chemosensitive and post-resistance samples, and end-stage HGSC obtained from patients who underwent a research autopsy. We found that gene breakage involving tumor suppressors such as NF1 and RB1 is a common form of inactivation in HGSC and in other circumstances contributes to acquired chemotherapy resistance in some patients. We found evidence of a chemotherapy footprint in the genome of recurrent tumor samples. We observed a striking degree of diversity of other mechanisms of acquired resistance, including multiple independent germline BRCA1 or BRCA2 reversion events in individual patients, loss of BRCA1 promoter methylation, a shift in molecular subtype to a desmoplastic phenotype, and a recurrent promoter fusion associated with overexpression of a driver of drug resistance, validated in an independent dataset. Collectively these findings underscore the plasticity of the HGSC genome and indicate that pre-empting resistance by modifying current first line therapy or countering it when it emerges will require a diversity of approaches. Citation Format: David D. L. Bowtell. Determinants of resistance and response in high-grade serous ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr IA12.
Receptor Protein Tyrosine Phosphatase α–Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice
Authors: Stephanie M. Stanford, Mattias N. D. Svensson, Cristiano Sacchetti, Caila A. Pilo, Dennis J. Wu, William B. Kiosses, Annelie Hellvard, Brith Bergum, German R. Aleman Muench, Christian Elly, Yun‐Cai Liu, Jeroen den Hertog, Ari Elson, Jan Sap, Piotr Mydel, David L. Boyle, Maripat Corr, Gary S. Firestein, Nunzio Bottini
Journal: Arthritis & Rheumatology (2015)

Objective During rheumatoid arthritis (RA), fibroblast‐like synoviocytes (FLS) critically promote disease pathogenesis by aggressively invading the extracellular matrix of the joint. The focal adhesion kinase (FAK) signaling pathway is emerging as a contributor to the anomalous behavior of RA FLS. The receptor protein tyrosine phosphatase α (RPTPα), which is encoded by the PTPRA gene, is a key promoter of FAK signaling. The aim of this study was to investigate whether RPTPα mediates FLS aggressiveness and RA pathogenesis. Methods Through RPTPα knockdown, we assessed FLS gene expression by quantitative polymerase chain reaction analysis and enzyme‐linked immunosorbent assay, invasion and migration by Transwell assays, survival by annexin V and propidium iodide staining, adhesion and spreading by immunofluorescence microscopy, and activation of signaling pathways by Western blotting of FLS lysates. Arthritis development was examined in RPTPα‐knockout (KO) mice using the K/BxN serum–transfer model. The contribution of radiosensitive and radioresistant cells to disease was evaluated by reciprocal bone marrow transplantation. Results RPTPα was enriched in the RA synovial lining. RPTPα knockdown impaired RA FLS survival, spreading, migration, invasiveness, and responsiveness to platelet‐derived growth factor, tumor necrosis factor, and interleukin‐1 stimulation. These phenotypes correlated with increased phosphorylation of Src on inhibitory Y 527 and decreased phosphorylation of FAK on stimulatory Y 397 . Treatment of RA FLS with an inhibitor of FAK phenocopied the knockdown of RPTPα. RPTPα‐KO mice were protected from arthritis development, which was due to radioresistant cells. Conclusion By regulating the phosphorylation of Src and FAK, RPTPα mediates proinflammatory and proinvasive signaling in RA FLS, correlating with the promotion of disease in an FLS‐dependent model of RA.
Marital therapy from a psychiatric perspective: an overview
Authors:  Berman-M, H I Lief
Journal: American Journal of Psychiatry (1975)

The authors describe various methods of marital therapy in use today. Although absence of a unifying conceptual scheme in the past has hampered developments in this field, the increasing acknowledgment by psychiatrists of the important effect of the environmental system on thoughts, feelings, and behavior has facilitated a therapeutic approach stressing not only a person's intrapsychic conflicts but current environmental, family, and spouse-related phenomena. The authors discuss three dimensions of marital psychodynamics--power, intimacy, and marital boundary setting--and relate them to the marital life cycle and to four classifications of the marital relationship: 1) rules for defining power, 2) parental stage, 3) level of intimacy, and 4) personality style and psychiatric terminology. The paper includes a brief discussion of therapy techniques, sex counseling, the use of cotherapists, the future of marriage, and alternative lifestyles.
Mesenteric Panniculitis Demonstrated on 18F-FDG PET/CT
Authors: Domenico Albano, Giovanni Bosio, Francesco Bertagna
Journal: Clinical Nuclear Medicine (2015)

Mesenteric panniculitis is an underdiagnosed inflammatory condition of unknown etiology that involves the mesenteric adipose tissue. Clinical symptoms are not specific (fever, abdominal pain, or nausea), so diagnosis is not simple. We report a case of 48-year-old man with abdominal pain and fever not responsive to antipyretics and antibiotics for 2 months, who underwent an F-FDG PET/CT after a nondiagnostic CT scan. PET/CT has proven to be a useful method for the diagnosis of mesenteric panniculitis in this patient, showing a uniformly high uptake of FDG in the mesenteric adipose tissue of the mesocolon, mesoappendix, mesosigmoid, and mesorectum.
Evolution of antibiotic resistance of non-typhoidal salmonellae in Greece during 1990-97
Authors: E N Velonakis, A Markogiannakis, L Kondili, E Varjioti, Z Mahera, N Vakalis, E Dedouli, A Karaitianou, K Bethimouti
Journal: Eurosurveillance (2001)

Susceptibility to 15 antibiotics was determined in 1548 non-typhoidal salmonella strains isolated in Greece from l990 to l997. The overall prevalence of resistance of both Salmonella enterica serotype Enteritidis and Salmonella enterica serotype Typhimurium increased during the first years of the study. A decrease was observed from 1996, especially for S. Enteritidis, which showed the highest overall antibiotic resistance. S. Typhimurium was the serotype with the highest multiresistance to antibiotics. The rest of the serotypes had very low resistance prevalence compared with both S. Enteritidis and Typhimurium serotypes.