tbuckley/cabot-search huggingface dataset:
Abstract P2-09-38: Role of Oncotype 21 Gene Assay and Adjuvant! Online in Breast Cancer Adjuvant Treatment Decisions
Authors: DN Khalil, JG Schneider
Journal: Cancer Research (2010)

Abstract Background: Based upon its validation as both a prognostic and predictive tool, the Oncotype 21 gene RS has been broadly adopted into clinical practice, but little has been reported on how RS actually influences clinical decision making in practice. Methods: A retrospective chart review was performed on all patients for whom a RS was requested within a single faculty practice since the RS became commercially available in 2005. Data were collected to identify: (1) reasons for requesting RS; (2) reasons for RS cancellations; (3) traditional recurrence risk factors enabling alternative prognostic calculations including the Nottingham Prognostic Index and Adjuvant! Online (AOL) web based instrument; and (4) actual adjuvant treatment decisions. Clinician interviews were performed to confirm RS influence on clinician practice and to compare hypothetical and actual treatment decisions. Results: 109 RS were requested by five different clinicians. 87 RS were obtained on ER+, node-negative patients. The 10-year relapse risk predicted by RS versus that predicted by AOL is plotted in Figure 1 where the actual adjuvant treatment decision is coded and lines are introduced to separate low, intermediate and high risk groups. In patients with a low RS for whom a treatment decision was made, only 1 of 17 (6%) with an intermediate AOL relapse rate, and 4 of 21 (19%) with a high AOL relapse rate, were treated with chemotherapy. These data suggest that a favorable RS recurrence rate influenced the decision not to initiate chemotherapy when the AOL-predicted relapse rate was less favorable. Two distinct areas of “clinical equipoise” were identified where the combination of AOL and RS risks left clinicians ambivalent about the use of adjuvant chemotherapy (AOL 23-26 with RS 11-15, and AOL 29-43 with RS 5-11). Apparent inconsistencies between RS and adjuvant treatment decisions as well as alternative reasons for obtaining RS were identified and reviewed with the treating clinicians. Conclusions: This single institution experience indicates appropriate use of RS in adjuvant ER+ node-negative breast cancer. The predominant effect in this group was to reduce the utilization of adjuvant chemotherapy in patients with intermediate and high relapse risk predicted by conventional prognostic factors. Figure available in online version. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-09-38.
Fibrodysplasia Ossificans Progressiva Detected on FDG PET/CT
Authors: Sumeet G Dua, Sneha Shah, Nilendu C Purandare, Brijesh Arora, Venkatesh Rangarajan
Journal: Clinical Nuclear Medicine (2011)

Fibrodysplasia ossificans progressiva (FOP) is a genetic disorder of the skeletal system which, due to its rarity, is frequently misdiagnosed for a malignancy (Kitterman et al. Pediatrics. 2005;116:e654–e661). Consequently, these patients are subjected to multiple invasive diagnostic and therapeutic procedures which instead can aggravate the disease (Kitterman et al. Pediatrics. 2005;116:e654–e661). Recognition of the computed tomography appearance of FOP is thus vital, as these patients are likely to be referred for a positron emission tomography/computed tomography (PET/CT) to stage a misdiagnosed cancer. In this study, the PET/CT features of FOP are demonstrated in a child who was referred for staging of an erroneously diagnosed lymphoma.
Abstract 1897: Metformin treatment leads to the accumulation of lipid in breast cancer cell lines - a potential new biomarker of response and mechanism of action.
Authors: Simon Lord, Jennifer Collins, Barbara Fielding, Neel Patel, Fergus Gleeson, Adrian Harris, Fredrik Karpe
Journal: Cancer Research (2013)

Abstract There is growing interest in the anticancer effect of the diabetes drug, metformin, and several clinical studies are underway worldwide. Metformin's anticancer effects are thought to be mediated by its activation of AMPK and subsequent downstream catabolic effects on protein and lipid metabolism pathways that are commonly dysregulated in cancer cells. We have used mass spectrometry techniques and stable isotopes to investigate the effects of metformin on breast cancer cell lipid metabolism. There was great variability in lipid metabolism response to 2mM metformin treatment in a panel breast cancer cell lines (MCF7, BT474, ZR-75-1, T47D MDA-MB-157, MDA-MB-468 and MDA-MB-231). Levels of stearic acid (p=0.019), palmitoleic acid (p=0.01), oleic acid (p=0.002), cis-vaccenic acid (p=0.003) increased 3-4 fold with metformin treatment in MCF7 cells but there was no significant change for MDA-MB-231 cells. 2mM Metformin decreased fatty acid β-oxidation of oleate 4-fold (p=0.03). Accumulation of de novo lipogenesis derived (p=0.004) and exogenous fatty acid (p=0.02) occurred in MCF7 cells but siRNA knockdown of AMPK did not abrogate these effects. A 3-fold decrease in the diglyceride to triglyceride ratio (p=0.02) suggested reduced lipolysis and inhibited adipose triglyceride lipase activity. Reduced incorporation of exogenous fatty acid into phospholipid was evident (p=0.002). Heterogeneity of lipid metabolism response correlated with effects on proliferation, oxygen consumption and mitochondrial morphology. Our data shows that metformin has marked effects on accumulation of fatty acid in breast cancer cells most likely due to reduced lipolysis and β-oxidation and these effects cannot be explained as a result of AMPK activation. This work will contribute to developing biomarkers for metformin's metabolic anticancer effect and our understanding of how to combine it with other therapies to exploit synthetic lethality. We have initiated a multicenter, phase II, single arm clinical study, to further characterise metformin influenced, cancer relevant metabolic pathways. We will look to assess the correlation between metabolic biomarkers, including the use of mass spectrometry and gas chromatography analysis of tissue samples, and metabolic response using 18F-FDG PET-CT scans. Citation Format: Simon Lord, Jennifer Collins, Barbara Fielding, Neel Patel, Fergus Gleeson, Adrian Harris, Fredrik Karpe. Metformin treatment leads to the accumulation of lipid in breast cancer cell lines - a potential new biomarker of response and mechanism of action. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1897. doi:10.1158/1538-7445.AM2013-1897
P279 INCREASED LEVELS OF SERUM ALANINE IMPAIR NK FUNCTION AND PREDICT SEVERITY OF LIVER FIBROSIS IN NAFLD PATIENTS
Authors: J. Amer, H. Bsaiso, M. Mahamid, L. Abu-Tair, S. Doron, R. Ghantous, R. Safadi
Journal: Journal of Hepatology (2014)
Abstract 4991: Functional significance of potential oncogene <i>YAP</i> and its isoforms in esophageal squamouse cell carcinoma (ESCC)
Authors: Tomoki Muramatsu, Issei Imoto, Takeshi Matsui, Ken-ichi Kozaki, Hitoshi Tsuda, Yutaka Shimada, Johji Inazawa
Journal: Cancer Research (2010)

Abstract Previously, we reported cIAP1 to be overexpressed through 11q22 amplification in some ESCC cell lines. YAP, a key molecule in Hippo pathway reported as a possible oncogene in some cancers, locates within the same amplicon in those ESCC lines. Since YAP overexpression was frequently observed in primary ESCC, YAP may work as an oncogene for ESCC. Through expression analyses of mRNA and protein, we identified two novel isoforms of YAP other than two known isoforms. Expression pattern of YAP isoforms was different between normal esophagus and ESCCs, suggesting each isoform to have different function as an oncogene. We constructed stably-transfected cells with siRNA-resistant construct of each of YAP isoforms. We then performed knockdown of endogenous YAP to investigate whether any difference in growth-promoting effect exists among these isoforms. Growth inhibition of ESCC cells with induction of p21 was observed by knockdown of YAP, and each isoform partially rescued siRNA-induced p21 elevation and growth inhibition, although only the small difference was observed among isoforms. Those results suggest that induction of p21 might be regulated by transcriptional repressor YAP, directly or indirectly. Detail analysis of functional significance of YAP will provide not only new avenues for understanding the esophageal carcinogenesis, but also development of YAP-targeted cancer therapy in ESCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4991.
NI-83 * DIFFUSION AND CONVENTIONAL MR IMAGING GENOMIC BIOMARKER SIGNATURE PREDICTS IDH-1 MUTATION IN GLIOBLASTOMA PATIENTS
Authors: E. Wassal, P. Zinn, R. Colen
Journal: Neuro-Oncology (2014)

PURPOSE: The IDH-1(R132H) mutation is one of the strongest prognostic predictors and a diagnostic hallmark of gliomas that is independent of other known prognostic factors, including age, grade, and O6-methylguanine-DNA methyltransferase (MGMT) methylation status and thus has a major clinical relevance. Given the latter, it will likely be integrated into the new WHO classification for GBM. Currently used methods to determine the IDH-1 mutation status of GBM include immunohistochemical analysis and genotyping of the DNA extracted from the tumor specimens. Thus, we seek to identify a diffusion and conventional MR imaging signature associated with IDH-1 mutated tumors that can be considered as a non-invasive predictor of the IDH1 status in Glioblastoma patients. MATERIALS AND METHODS: We identified 80 GBM patients from TCGA who had both genetic expression profiles of IDH-1 and mutation status and neuroimaging available at The Cancer Imaging Archive (TCIA). All morphological image analyses and segmentation were done using slicer 3.6 and reviewed in consensus by 3 neuroradiologists. Fluid-Attenuated Inversion Recovery (FLAIR) was used for segmentation of the edema and post-contrast T1 weighted imaging (T1WI) for segmentation of enhancement and necrosis. Diffusion was analyzed in Olea Sphere 2.3 and Conventional FLAIR/post-contrast T1WI was registered to DWI/ADC maps. ADC,FLAIR,T1 Gadolinium enhancement values were measured using the ROI based method,in the peri-tumoral edema/tumor infiltration and the enhancing tumor zones, with dividing the peri-tumoral edema/tumor infiltration into 3 zones each of 1 cm width, 3 ROI measurements were taken from each zone. Multiple quantitative imaging features were combined to create the imaging biomarker signature predictive of IDH-1 mutation status. RESULTS: We created a complex imaging biomarker signature using quantitative diffusion and conventional MR imaging features to predict those GBM patients with IDH-1 mutation and was predictive of patient survival. CONCLUSIONS: GBM tumors with IDH-1 mutation hold a specific diffusion and conventional MR imaging biomarker signature that can be used as a predictive and prognostic biomarker and non-invasive surrogate for IDH-1 status detection.
TRAUMATIC PSYCHOSES
Authors: Clarence A. Bonner, Lois E. Taylor
Journal: American Journal of Psychiatry (1936)

I. This study brings out the rarity with which traumatic psychoses occur, as our series covered a period of 16 years and avenged only one-half of one per cent of first admissions to the hospital. II. In comparison with the severity of the psychosis shown, the duration of stay in the hospital and subsequent adjustment, both social and economic, is better than might be expected, with the exception of the cases of post-traumatic mental deterioration, which usually require continued hospital care. III. The factor of over-indulgence in alcohol has a definite relation both to the causation of the accident and to the adjustment of such patients after leaving the hospital. The adaptation is consistently on a lower level than in the cases in which alcohol is not used excessively. IV. The occupational limitation of our patients to the classes of tradespeople and laborers may somewhat nullify the optimistic outlook as to social and economic readjustment, for naturally their rehabilitation is not on a high plane. The one case of a professional person showed that he was unable to resume his law practice and former social activities. It is very possible that head trauma may have a more disastrous effect on those who have formerly engaged in professions or more intellectual and specialized occupations than on those whose economic life has been more one of routine and manual labor. The realization, however, that the greater part of our population is made up of tradespeople and laborers justifies the expectation that a reasonably satisfactory recovery from a traumatic psychosis will be made in the majority of cases. V. The type of injury sustained seems to play an important part in the adjustment of the patient to his former surroundings. The cases of fracture of the skull are less apt to readjust socially than the ones with head injury without fracture and are markedly less able to resume their former occupations than the latter. This should be an important consideration in prognosis. VI. The most common of the sequelæ of traumatic psychoses appear to be: continued irritability; headache; dizziness; and, to a lesser extent, irresponsibility, with impaired judgment. In the deteriorative forms, we find immaturity and disturbances of the intellectual faculties. VII. While it is true that the traumatic psychoses, in proportion to the other psychoses, are relatively rare, much can be done for them in the nature of prevention by modern methods of treatment that have been so well set forth in the new literature on the subject. VIII. It would seem that but a small proportion of head injuries develop psychoses. It is well-known, however, that they do not escape entirely from mental or nervous defects and that a huge number constantly develop the neuroses, which ordinarily remain as neuroses and do not develop into psychoses.
PERIPHERAL ARTERY STENT THROMBOSIS: REPORT FROM THE EXCELLENCE IN PERIPHERAL ARTERY DISEASE (XLPAD) REGISTRY
Authors: Subhash Banerjee, Karan Sarode, Atif Mohammad, Osvaldo Gigliotti, Michael Luna, Tayo Addo, Mirza Baig, Shirling Tsai, Nicolas Shammas, Anand Prasad, Mazen Abu-Fadel, Andrew Klein, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2015)
Needs in the Field of Psychologic Appraisal of Children with Cerebral Palsy
Authors: Eric Denhoff
Journal: New England Journal of Medicine (1950)

THE basic need in the field of psychologic appraisal in cerebral palsy seems to me to be the development of a simple test or group of tests that can be used by the average psychologist or physician to determine whether a child with cerebral palsy has the ability to achieve some measure of normal mental and emotional status in adulthood. To develop a need like this obviously is not simple since many aspects of cerebral palsy are not yet clarified even in the minds of persons working exclusively in this field.For instance, there is still little correlation between causes, . . .
SAT0582-HPR Occupational Characterization and Relation between Working Condition and Disease Activity or Functionality in Patients with Rheumatoid Arthritis
Authors: D. Beltran, A. Urbina, C. Sandoval, L. Villarreal, A. P. Real, P. Boon, A. Palomino, P. Santos-Moreno
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is a disease that in most cases is associated with disability and loss of earning capacity. There is a lack of information about occupation of rheumatoid arthritis patients in Colombia, being this field important in order to improve clinical and social outcomes for them. On the other hand, there are no data about the relationship between working or not-working condition with RA activity and functional status, being this information relevant for implementation of social programs for this population. <h3>Objectives</h3> The aim of this study was to describe the occupation in a cohort of RA patients and to describe functionality and disease activity and it`s possible relationship with working or retirement condition in a cohort of RA patients in a specialized center in Colombia. <h3>Methods</h3> A descriptive cross sectional study was realized. A revision of medical records of a cohort of RA patients was performed, including occupational therapy records. Each patient was evaluated for DAS28, HAQ and OPHI2 (Occupational Performance History Interview 2). Patients were classified in two categories: working and retirement condition, last one was divided into: retirement because of age and retirement for disability. Descriptive epidemiology was done, percentages and averages were calculated; and Pearson´s statistics was used for by-variated analysis. <h3>Results</h3> Of the 177 RA patients included, 147 (83.1%) were women and 30 (16.9%) were men. Mean age 59.6 y/o, for women 58.6 and for men 60.6. Average DAS 28 for all patients 2.73 (2.85 for women and 2.62 for men), average HAQ were 0.29 (0.33 for women and 0.25 for men). Retired workers were 77.9% and active workers 22.1%. Administrative workers were 34 (19.2%), house keepers were 34 (19.2%), high impact workers (machine operators, sewing operators and others) were 25 (14.1%), low impact workers (maid services, health workers and others) were 78 (44.1%), no well-defined condition were 6 (3.4%). Regarding DAS28 and HAQ in average for administrative workers were 3.0 and 0.25, for house keepers were 2.44 and 0.29, for high impact workers were 2.81 and 0.41, for low impact workers were 2.97 and 0.34. It was established correlation between occupation and disease activity (p &lt; 0.0099), but not with functionality. <h3>Conclusions</h3> Interestingly most active RA patients were administrative workers, followed by low impact workers. In general for all types of occupations HAQ scores were low. Study suggests working patients had more active disease (average moderate activity) compared to retired patients (mild activity), but they had better functionality than retired patients. <h3>Disclosure of Interest</h3> None Declared
A Prospective Comparison of Clinical Examination, MRI, Bone SPECT, and Arthroscopy to Detect Meniscal Tears
Authors: P. J. RYAN, K. REDDY, J. FLEETCROFT
Journal: Clinical Nuclear Medicine (1998)

Recent studies have shown that SPECT bone scintigraphy is valuable to detect meniscal tears of the knee. This has not been formally assessed in a prospective study, and no substantive study has compared bone SPECT with other noninvasive diagnostic methods. One hundred consecutive patients referred to an orthopedic surgeon with undiagnosed knee pain were assessed by clinical examination, MRI, SPECT bone scintigraphy, and arthroscopy. The MRI and SPECT bone scan findings were reported blinded to other information. Using arthroscopy as a gold standard, both MRI and SPECT showed high diagnostic ability to detect meniscal tears, with respective sensitivity rate, specificity rates, and positive and negative predictive accuracies of 80%, 71%, 84%, and 71% for MRI and 84%, 80%, 88%, and 76% for SPECT. Some meniscal tears were detected by MRI alone (n = 5) or SPECT alone (n = 8). SPECT bone scintigraphy is a suitable alternative to MRI to detect meniscal tears. The comparable diagnostic ability of SPECT bone scintigraphy implies that it can be used successfully when MRI is unavailable or unsuitable.
Abstract P2-10-36: Analysis of biomarker expression and biological subtype in primary tumour, corresponding lymph node and distant metastasis with 5-year follow-up
Authors: A-K Falck, M Ferno, P-O Bendahl, G Chebil, H Olsson, L Rydén
Journal: Cancer Research (2012)

Abstract Background: Biological variation in genotype and phenotype of primary breast cancer explains the heterogeneity of the disease and subsequent outcome. Choice of treatment is routinely based on the biomarker expression of the primary tumour with regard to estrogen- (ER) and progesterone (PR) receptor status, human epidermal growth factor receptor 2 (HER2) status and the proliferation marker Ki67, individually. Recently, gene expression profiling and subsequent immunohistochemical studies have identified biologically distinct subtypes by using a combination of biomarkers which have been shown to be of prognostic value beyond the previous known. However, tumour progression theories propose a change in biomarker expression during development from primary tumour to distant metastasis with implications on choice of therapy. The aim of this study was to compare biomarker expression individually and according to biological subtype between tumour samples from primary tumour, lymph node metastasis and distant metastasis from the same patient. Material and methods: From an original cohort of 569 patients with primary breast cancer, tissue microarrays were constructed from archival tissue blocks of primary tumour (n = 521), paired lymph node metastasis (n = 147) and biopsies from distant metastasis (n = 42). The samples were evaluated by two independent pathologists. The individual biomarker expression as well as subtype classification (Luminal A: ER+ and/or PR+, Ki67≤ 20% and HER2−. Luminal B: ER+ and/or PR+, Ki67&amp;gt; 20% and/or HER2+. HER2 type: ER/PR−, HER2+. Basal-like: ER/PR−, HER2−, CK5/6+ and/or EGFR+) were compared between primary tumour, lymph node metastasis and distant metastasis. Survival outcome were estimated using the Kaplan-Meier method and log rank test. The primary end-point was distant disease-free survival (DDFS). Results: Distribution according to subtype. The molecular subgroups in the primary tumours were associated with statistically significant prognostic information by log-rank test (p = 0.005) validating luminal A as a subgroup with excellent prognosis. More detailed survival analysis comparing expression of biomarkers between primary tumour, lymph node metastasis and distant metastasis will be presented. Conclusion: Prognostic information can be obtained by subtype classification using routine-based biomarker analysis in the primary tumour. Preliminary data suggest that the subtype distribution is associated with a worse prognostic profile in the lymph node- and distant metastasis. Detailed survival analysis will be presented at the meeting. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-36.
Handcrafted two-channel colonoscope for grasping forceps-assisted resection of large pedunculated polyps in the sigmoid colon
Authors: M. Matsushita, T. Tanaka, Y. Fukui, Y. Ando, N. Fukata, S. Kawamata, K. Okazaki
Journal: Endoscopy (2013)

We read with interest the article by Yang and Yen [1] on combined biopsy forceps and scissor forceps for cutting an endoloop entrapped in a large pedunculated polyp in the sigmoid colon. The endoloop could not be cut with a scissor forceps because it easily slipped away from the blades. The endoloop was removed successfully by using a two-channel endoscope to combine biopsy forceps for grasping the endoloop and scissor forceps for cutting the endoloop. Although the polyp was finally resected after application of an additional endoloop, we recommend the initial use of a two-channel endoscope in such patients.
CLINICAL OUTCOMES OF ENDOVASCULAR TREATMENT FOR CHRONIC AORTIC CCCLUSION
Authors: Taku Kato, Kan Zen, Osami Kawarada, Koji Hozawa, Hitoshi Anzai, Hiroaki Nakamura, Tetsuya Nomura, Atsushi Funatsu, Daizo Kawasaki, Yoshinori Tsubakimoto, Akihiro Higashimori, Satoaki Matoba
Journal: Journal of the American College of Cardiology (2016)
Influence of cytotoxicity enhancers in combination with human serum on the activity of CD22-recombinant ricin A against B cell lines, chronic and acute lymphocytic leukemia cells
Authors: PJ van Horssen, YVJM van Oosterhout, S Evers, HHJ Backus, MGCT van Oijen, R Bongaerts, T de Witte, FWMB Preijers
Journal: Leukemia (1999)