tbuckley/cabot-search huggingface dataset:
Abstract 595: Digital PCR validates 8q dosage as prognostic tool in uveal melanoma
Authors: Mark J. de Lange, Mieke Versluis, Sake van Pelt, Claudia A.L. Ruivenkamp, Wilma G. Kroes, Jinfeng Cao, Martine J. Jager, Gre P.M. Luyten, Pieter A. van der Velden
Journal: Cancer Research (2015)

Abstract Background: Uveal melanoma (UM) development and progression is correlated with specific molecular changes. Recurrent mutations in GNAQ and GNA11 initiate UM development while tumour progression is correlated with monosomy of chromosome 3 and gain of chromosome 8q. Hence, molecular analysis of UM is useful for diagnosis and prognosis. The aim of this study is to evaluate the use of digital PCR (dPCR) for molecular analysis of UM. Methods: A series of 66 UM was analysed with dPCR for three hotspot mutations in GNAQ/GNA11 with mutation specific probes. The status of chromosomes 3 and 8 were analysed with genomic probes. The results of dPCR analysis were cross-validated with Sanger sequencing, SNP array analysis, and karyotyping. Results: Using dPCR, we were able to determine the molecular profile of 66 enucleated UM. With digital PCR, GNAQ/GNA11 mutations were detected in 60 of the 66 UM. Sanger sequencing revealed three rare variants, and, combined, these assays revealed GNAQ/GNA11 mutations in 95% of UM. Monosomy 3 was present in 43 and chromosome 8 aberrations in 52 of the 66 UM, with dPCR and SNP results showing an excellent correlation (for monosomy 3 r = 0.921, for 8q gain r = 0.922). Survival analysis showed that increasing 8q copy numbers were positively correlated with metastasis risk. Conclusion: Molecular analysis with dPCR is fast and sensitive. Just like the recurrent genomic aberrations of chromosome 3 and 8, hotspot mutations in GNAQ and GNA11 are effectively detected in heterogeneous samples. Increased sensitivity contributes to the number of mutations and chromosomal aberrations detected. Moreover, quantification of copy number with dPCR validated 8q dosage as a sensitive prognostic tool in UM, of which implementation in disease prediction models will further improve prognostication. Citation Format: Mark J. de Lange, Mieke Versluis, Sake van Pelt, Claudia A.L. Ruivenkamp, Wilma G. Kroes, Jinfeng Cao, Martine J. Jager, Gre P.M. Luyten, Pieter A. van der Velden. Digital PCR validates 8q dosage as prognostic tool in uveal melanoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 595. doi:10.1158/1538-7445.AM2015-595
Systemic inhibition of IL-6/Stat3 signalling protects against experimental osteoarthritis
Authors: Augustin Latourte, Chahrazad Cherifi, Jérémy Maillet, Hang-Korng Ea, Wafa Bouaziz, Thomas Funck-Brentano, Martine Cohen-Solal, Eric Hay, Pascal Richette
Journal: Annals of the Rheumatic Diseases (2016)

To investigate the impact of systemic inhibition of interleukin 6 (IL-6) or signal transducer and activator of transcription (Stat3) in an experimental model of osteoarthritis (OA).Expression of major catabolic and anabolic factors of cartilage was determined in IL-6-treated mouse chondrocytes and cartilage explants. The anti-IL-6-receptor neutralising antibody MR16-1 was used in the destabilisation of the medial meniscus (DMM) mouse model of OA. Stat3 blockade was investigated by the small molecule Stattic ex vivo and in the DMM model.In chondrocytes and cartilage explants, IL-6 treatment reduced proteoglycan content with increased production of matrix metalloproteinase (MMP-3 and MMP-13) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS-4 and ADAMTS-5). IL-6 induced Stat3 and extracellular signal-regulated kinase (ERK) 1/2 signalling but not p38, c-Jun N-terminal kinase or Akt. In the DMM model, Stat3 was activated in cartilage, but neither in the synovium nor in the subchondral bone. Systemic blockade of IL-6 by MR16-1 alleviated DMM-induced OA cartilage lesions, impaired the osteophyte formation and the extent of synovitis. In the same model, Stattic had similar beneficial effects on cartilage and osteophyte formation. Stattic, but not an ERK1/2 inhibitor, significantly counteracted the catabolic effects of IL-6 on cartilage explants and suppressed the IL-6-induced chondrocytes apoptosis.IL-6 induces chondrocyte catabolism mainly via Stat3 signalling, a pathway activated in cartilage from joint subjected to DMM. Systemic blockade of IL-6 or STAT-3 can alleviate DMM-induced OA in mice.
Reply to A. Braillon, M. Boulin et al, and J.-H. Zhong et al
Authors: Karen T. Brown, Richard Do, Mithat Gönen, Anne M. Covey, George I. Getrajdman, Constantinos T. Sofocleous, William R. Jarnagin, Michael I. D'Angelica, Peter J. Allen, Joseph P. Erinjeri, Lynn A. Brody, Gerald P. O’Neill, Kristian Johnson, Alessandra R. Garcia, Christopher M. Beattie, Binsheng Zhao, Stephen B. Solomon, Lawrence H. Schwartz, Ronald P. DeMatteo, Ghassan K. Abou-Alfa
Journal: Journal of Clinical Oncology (2017)
A prospective study of blood trans fatty acid levels and risk of prostate cancer
Authors: Jorge Chavarro, Meir Stampfer, Hannia Campos, Tobias Kurth, Walter Willett, Jing Ma
Journal: Cancer Research (2006)

4004   Purpose: Results from two previous studies suggest a positive association between markers of  trans  fatty acid (TFA) intake and prostate cancer. We therefore prospectively evaluated the association between blood TFA levels and risk of prostate cancer. Methods: We conducted a nested case-control study among 14,916 U.S. physicians who provided a blood sample in 1982. Blood samples were frozen at baseline and kept at −82° C until assayed. Incident prostate cancer cases accrued through 1995 were matched to controls by age, smoking status at baseline and length of follow-up. TFA levels as percentage of total fatty acids were determined for 479 cases and their 491 matched controls using gas chromatography. Cases and controls were divided into quintiles according to the distribution of TFA levels among the controls. Conditional logistic regression models were used to estimate the relative risk (RR) and 95% confidence interval (95% CI) of prostate cancer in a given quintile of TFA level in relation to the lowest quintile. Results: Levels of 16:1, 18:1 and total TFAs were not associated with prostate cancer risk. There was a weak positive association between levels of 18:2 TFAs, which result from the hydrogenation of linoleic acid, and prostate cancer risk. The RRs (95% CI) for men in successively higher quintiles of TFA levels were 0.87 (0.57 –1.33), 1.24 (0.83 –1.87), 1.69 (1.12 –2.55) and 1.24 (0.81 –1.88), compared to men in the lowest quintile (P trend  = 0.09). The association was similar for the three 18:2  trans  isomers examined: n-6  trans trans (tt) , cis trans (ct) and  trans cis (tc). When results were divided according to tumor stage at diagnosis, levels of 18:1, 18:2 and total TFAs were positively related to the risk of developing organ confined, but not advanced, tumors. The RRs (95% CI; P trend ) of localized prostate cancer comparing the highest and lowest quintile of TFAs were 2.11 (1.22 –3.64: 0.05) for total, 1.85 (1.08 –3.16: 0.15) for 18:1, and 1.84 (1.05 –3.22: 0.003) for 18:2 TFAs. Similar results were obtained for non-aggressive tumors (organ confined and Gleason ≤ 7). The RRs (95% CI; P trend ) of non-aggressive prostate cancer comparing extreme quintiles of total, 18:1 and 18:2 TFA levels were 2.47 (1.32 –4.63: 0.01), 2.10 (1.13 –3.91: 0.06) and 2.29 (1.22 –4.30:   7). Further adjustment for potential confounders did not substantially change these results. Conclusions: Our prospective data suggests that blood levels of  trans  fatty acids, in particular  trans  fats resulting from the hydrogenation of vegetable oils, are associated with an increased prostate cancer risk. This association appears to be specific to organ confined and non-aggressive tumors.
TCT-242 Temporal Changes in Outcomes after Stent or Coronary Artery Bypass Grafting for Left Main Coronary Artery Disease by Diabetes Status
Authors: Min Soo Cho, Ungjeong Do, Kyusup Lee, Jung Ae Hong, Osung Kwon, Do-yoon Kang, JAESEOK BAE, Cheol Hyun Lee, Yu Na Kim, Se Hun Kang, Sung-Han Yoon, Pil Hyung Lee, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2016)
Inactivation of JAK/STAT Cell Signaling by SK-7041, a Novel HDAC Inhibitor, Effectively Inhibits Growth of Acute Myeloid Leukemia Cells
Authors: Byung-Su Kim, Chansu Lee, Juwon Park, Kwang-Sung Ahn, Byoung Kook Kim, Seonyang Park, Young-Yiul Lee, Sung-Soo Yoon
Journal: Blood (2008)
TCT-340 Drug eluting stents versus bare metal stents in all comer population undergoing PCI of saphenous vein graft in 1-year follow-up (SVG Silesian Registry)
Authors: Wojciech Wanha, Tomasz Roleder, Szymon Ladzinski, Sylwia Gladysz, Tomasz Pawlowski, Grzegorz Smolka, Andrzej Ochala, Michał Tendera, Wojtek Wojakowski
Journal: Journal of the American College of Cardiology (2016)
TCT-594 Difference in Neointimal Coverage between First Generation versus Second Generation Drug Eluting Stents using Optical Coherence tomography: A Meta-Analysis
Authors: Pradyumna Agasthi, Sivakanth Aloor, Vivek Menon, Kwan Lee, Gautam Kumar, Rajesh Sachdeva
Journal: Journal of the American College of Cardiology (2016)
PS01.61: Registry for the EVolution Of LUng Cancer Therapy Implementation and Outcomes Now (REVOLUTION): Registry Study in Progress
Authors: Edward Kim, Michaela Dinan, KM Monirul Islam, Ancilla Fernandes, Lee Schwartzberg, Elisabeth Croft, Julie Brahmer, Aaron Mansfield, Terry Hyslop, Lea Burke, Jeffrey Crawford
Journal: Journal of Thoracic Oncology (2016)
TCT-485 A study of safety and efficacy of biodegradable polymer coated Everolimus-eluting coronary stent system [Everoflex] at intermediate follow-up in real world scenario
Authors: Rajasekhar Durgaprasad, Velam Vanajakshamma, Vamsidhar Akkulagari, Latheef Kasala, Sreedhar Naik Kanavat, Pathakota Sudhakar Reddy
Journal: Journal of the American College of Cardiology (2016)
All-cause and cancer-specific mortality in GORD in a population-based cohort study (the HUNT study)
Authors: Eivind Ness-Jensen, Eivind Gottlieb-Vedi, Karl Wahlin, Jesper Lagergren
Journal: Gut (2016)

Objective Gastro-oesophageal reflux is a public health concern which could have associated oesophageal complications, including adenocarcinoma, and possibly also head-and-neck and lung cancers. The aim of this study was to test the hypothesis that reflux increases all-cause and cancer-specific mortalities in an unselected cohort. Design The Nord-Trøndelag health study (HUNT), a Norwegian population-based cohort study, was used to identify individuals with and without reflux in 1995–1997 and 2006–2008, with follow-up until 2014. All-cause mortality and cancer-specific mortality were assessed from the Norwegian Cause of Death Registry and Cancer Registry. Multivariable Cox regression was used to calculate HRs with 95% CIs for mortality with adjustments for potential confounders. Results We included 4758 participants with severe reflux symptoms and 51 381 participants without reflux symptoms, contributing 60 323 and 747 239 person-years at risk, respectively. Severe reflux was not associated with all-cause mortality, overall cancer-specific mortality or mortality in cancer of the head-and-neck or lung. However, for men with severe reflux a sixfold increase in oesophageal adenocarcinoma-specific mortality was found (HR 6.09, 95% CI 2.33 to 15.93) and the mortality rate was 0.27 per 1000 person-years. For women, the corresponding mortality was not significantly increased (HR 3.68, 95% CI 0.88 to 15.27) and the mortality rate was 0.05 per 1000 person-years. Conclusions Individuals with severe reflux symptoms do not seem to have increased all-cause mortality or overall cancer-specific mortality. Although the absolute risk is small, individuals with severe reflux symptoms have a clearly increased oesophageal adenocarcinoma-specific mortality.
TCT-186 Delayed versus immediate stenting strategy in ST segment elevation myocardial infarction - A meta analysis
Authors: Mahesh Anantha Narayanan, Yogesh NV. Reddy, Nagarjuna Gujjula, Dixitha Anugula, Janani Baskaran, Michael Delcore, Ganesh Raveendran
Journal: Journal of the American College of Cardiology (2016)
Cell Microarrays: Superhydrophilic–Superhydrophobic Patterned Surfaces as High‐Density Cell Microarrays: Optimization of Reverse Transfection (Adv. Healthcare Mater. 20/2016)
Authors: Erica Ueda, Wenqian Feng, Pavel A. Levkin
Journal: Advanced Healthcare Materials (2016)

Pavel A. Levkin and co-workers develop an ultra high-density cell microarray capable of efficiently and economically screening thousands of probes in a miniature and high-throughput format on page 2646. Surfaces patterned with superhydrophilic microspots separated by superhydrophobic barriers confined aqueous solutions and cells within each microspot. The cell microarrays are used to investigate the factors that affect reverse cell transfection efficiency and cell death.
TCT-694 Impact of Extracranial Carotid Artery Stenosis on Outcomes of Patients Undergoing Transcatheter Aortic Valve Replacement: Implications for Preprocedural Screening and Revascularization
Authors: Jeremy Ben-Shoshan, David Zahler, Arie Steinvil, Shmuel Banai, Gad Keren, Natan M. Bornstein, Ariel Finkelstein, Amir Halkin
Journal: Journal of the American College of Cardiology (2016)
TCT-64 Percutaneous coronary intervention for in-stent chronic total occlusion: procedural and long-term outcomes
Authors: Lorenzo Azzalini, Rustem Dautov, Soledad Ojeda, Barbara Bellini, Susanna Benincasa, Jorge Chavarria Viquez, Manuel Pan, Mauro Carlino, Antonio Colombo, Stéphane Rinfret
Journal: Journal of the American College of Cardiology (2016)
Interim and Post-Treatment Positron Emission Tomography-Computed Tomography Scan Status Is Highly Predictive Of Outcome In Diffuse Large Cell Lymphoma Patients Treated With R-CHOP21
Authors: Honghui Huang, Fei Xiao, Fangyuan Chen, Xiaofeng Han, Lu Zhong, Hua Zhong, Lan Xu, Jianyi Zhu, Beiwen Ni, Jia Liu, Tao Chen
Journal: Blood (2013)
TCT-583 Intravascular Ultrasound Comparison of Intra-plaque Versus Subintimal Tracking in Percutaneous Intervention for Coronary Chronic Total Occlusions
Authors: Lei Song, Akiko Maehara, Sanjog Kalra, Matthew Finn, Jeffrey Moses, Manish Parikh, Ajay Kirtane, Michael Collins, Tamim Nazif, Khady Fall, Ming Liao, Tiffany Kim, Philip Green, Ziad Ali, Gary Mintz, Dimitri Karmpaliotis
Journal: Journal of the American College of Cardiology (2016)
TCT-527 A data-driven approach combining image-based anatomical features and resting state measurements for the functional assessment of coronary artery disease
Authors: Lucian Calmac, Rodica Niculescu, Elisabeta Badila, Emma Weiss, Daniela Penes, Diana Zamfir, Lucian Itu, Laszlo Lazar, Marius Carp, Alexandru Itu, Constantin Suciu, Tiziano Passerini, Puneet Sharma, Bogdan Georgescu, Dorin Comaniciu
Journal: Journal of the American College of Cardiology (2016)
Crowdsourcing health communication about condom use in men who have sex with men in China: a randomised controlled trial
Authors: Weiming Tang, Jessica Mao, Chuncheng Liu, Katie Mollan, Haochu Li, Terrence Wong, Ye Zhang, Songyuan Tang, Michael Hudgens, Yilu Qin, Baoli Ma, Meizhen Liao, Bin Yang, Wei Ma, Dianmin Kang, Chongyi Wei, Joseph D Tucker
Journal: The Lancet (2016)
CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia
Authors: Jeevisha Bajaj, Takaaki Konuma, Nikki K. Lytle, Hyog Young Kwon, Jailal N. Ablack, Joseph M. Cantor, David Rizzieri, Charles Chuah, Vivian G. Oehler, Elizabeth H. Broome, Edward D. Ball, Edward H. van der Horst, Mark H. Ginsberg, Tannishtha Reya
Journal: Cancer Cell (2016)
Affinity maturation of a broadly neutralizing human monoclonal antibody that prevents acute hepatitis C virus infection in mice
Authors: Zhen‐Yong Keck, Yong Wang, Patrick Lau, Garry Lund, Sneha Rangarajan, Catherine Fauvelle, Grant C. Liao, Frederick W. Holtsberg, Kelly L. Warfield, M. Javad Aman, Brian G. Pierce, Thomas R. Fuerst, Justin R. Bailey, Thomas F. Baumert, Roy A. Mariuzza, Norman M. Kneteman, Steven K.H. Foung
Journal: Hepatology (2016)

Direct‐acting antivirals (DAAs) have led to a high cure rate in treated patients with chronic hepatitis C virus (HCV) infection, but this still leaves a large number of treatment failures secondary to the emergence of resistance‐associated variants (RAVs). To increase the barrier to resistance, a complementary strategy is to use neutralizing human monoclonal antibodies (HMAbs) to prevent acute infection. However, earlier efforts with the selected antibodies led to RAVs in animal and clinical studies. Therefore, we identified an HMAb that is less likely to elicit RAVs for affinity maturation to increase potency and, more important, breadth of protection. Selected matured antibodies show improved affinity and neutralization against a panel of diverse HCV isolates. Structural and modeling studies reveal that the affinity‐matured HMAb mediates virus neutralization, in part, by inducing conformational change to the targeted epitope, and that the maturated light chain is responsible for the improved affinity and breadth of protection. A matured HMAb protected humanized mice when challenged with an infectious HCV human serum inoculum for a prolonged period. However, a single mouse experienced breakthrough infection after 63 days when the serum HMAb concentration dropped by several logs; sequence analysis revealed no viral escape mutation. Conclusion : The findings suggest that a single broadly neutralizing antibody can prevent acute HCV infection without inducing RAVs and may complement DAAs to reduce the emergence of RAVs. (H epatology 2016;64:1922‐1933).
Gastrointestinal Illness Associated with Rancid Tortilla Chips at a Correctional Facility — Wyoming, 2015
Authors: Tiffany Lupcho, Alexia Harrist, Clay Van Houten
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

On October 12, 2015, a county health department notified the Wyoming Department of Health of an outbreak of gastrointestinal illness among residents and staff members at a local correctional facility. The majority of ill persons reported onset of symptoms within 1-3 hours after eating lunch served at the facility cafeteria at noon on October 11. Residents and staff members reported that tortilla chips served at the lunch tasted and smelled like chemicals. The Wyoming Department of Health and county health department personnel conducted case-control studies to identify the outbreak source. Consuming lunch at the facility on October 11 was highly associated with illness; multivariate logistic regression analysis found that tortilla chips were the only food item associated with illness. Hexanal and peroxide, markers for rancidity, were detected in tortilla chips and composite food samples from the lunch. No infectious agent was detected in human stool specimens or food samples. Extensive testing of lunch items did not identify any unusual chemical. Epidemiologic and laboratory evidence implicated rancid tortilla chips as the most likely source of illness. This outbreak serves as a reminder to consider alternative food testing methods during outbreaks of unusual gastrointestinal illness when typical foodborne pathogens are not identified. For interpretation of alternative food testing results, samples of each type of food not suspected to be contaminated are needed to serve as controls.
TCT-790 Cardiac Arrest Triage score best predicts mortality after intervention in patients with massive and submassive pulmonary embolism
Authors: Taishi Hirai, DeShon Jones, Steven Tate, Kathryn Dryer, Matthew Churpek, Lyn Santiago, Dana Edelson, Janet Friant, Sandeep Nathan, Atman Shah, Jonathan Paul, John Blair
Journal: Journal of the American College of Cardiology (2016)
TCT-788 Safety and Efficacy of Endovascular Therapy for Octogenarians with Peripheral Artery Disease presenting Intermittent Claudication due to Aortoiliac Lesions
Authors: Shota Okuno, Osamu Iida, Yoshimitsu Soga, Daizo Kawasaki, Yasutaka Yamauchi, Kenji Suzuki, Keisuke Hirano, Ryoji Koshida, Daisuke Kamoi, Junichi Tazaki, Michiaki Higashitani, Yoshiaki Shintani, Terutoshi Yamaoka, Shinya Okazaki, Nobuhiro Suematsu, Taketsugu Tsuchiya, Yusuke Miyashita, Norihiko Shinozaki, Antonella De Santis, Masaaki Uematsu
Journal: Journal of the American College of Cardiology (2016)
A peptide antagonist of chemokine receptor CXCR4 reduces tumor metastasis in a murine orthotopic model of human prostate cancer
Authors: Donald Wong, Walter Korz, Ahmed Merzouk, Hassan Salari
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

2162 

Prostate cancer is the second most common form of cancer in America and a leading cause of cancer-related deaths in men. The cure rate declines dramatically once the cancer metastasizes from the prostate glands to distant sites in the body. The main target for prostate cancer metastasis is bone. Prostate cancer cells are also commonly found in other organs surrounding the prostate area including the seminal vesicle, lymph nodes in the groin area and the rectum. Reports in the literature indicate that the expression of the chemokine receptor CXCR4 by prostate cancer correlates to their metastatic potential. CXCR4 is the receptor for the chemokine CXCL12, also known as stromal cell-derived factor-1 (SDF-1). The expression of SDF-1 is especially high in the bone marrow and is related to hematopoiesis. Cancer cells expressing CXCR4 home in to SDF-1 in the bone marrow and other specific organs. We have synthesized a number of analogs of SDF-1 using rational based drug design and some of these analogs have been shown to be antagonists of CXCR4. The lead compound of these synthetic antagonists, known as CTCE-9908, was tested in a murine orthotopic model of human prostate cancer (PC-3) for its ability to reduce metastases. Before initiation of in vivo studies, PC-3-GFP cells were mounted on poly-L-lysine-coated slides and stained with an anti-CXCR4 antibody. Varying degrees of CXCR4 expression was observed in all PC-3-GFP cells. For in vivo studies, two 1mm3 fragments of viable PC-3-GFP tumors harvested from the subcutaneous maintenance site of nude mice were sutured between two ventral lobes of the prostate in nude mice. Three days after tumor implantation, daily CTCE-9908 injections at a dose of 25 mg/kg/day IP or SC was initiated. Control mice received injections of vehicle. Mice were sacrificed after 4 weeks of treatment or when moribund. The fluorescent tumor pattern was then imaged. Analyses showed that the total area of metastasis was reduced from 370mm2 to 160mm2 for IP, and 130mm2 for SC. Reductions of 58% and 64%, respectively. This is consistent with findings of metastasis inhibition in other models including osteosarcoma, melanoma, and lung carcinoma. Further studies are in progress to determine optimal dose, scheduling, and combination with current therapies in this model. A phase I study has shown safety in healthy adults. A phase Ib/II study is expected to be initiated this year. The results to date suggest that the continued study of CTCE-9908 against a variety of metastatic tumor types is warranted.
TCT-107 Ticagelor is not superior to clopidogrel in patients with acute coronary syndrome – A report from SCAAR
Authors: Björn Redfors, Sebastian Volz, Oscar Angeras, Inger Haraldsson, Dan Ioanes, Jacob Odenstedt, Petur Petursson, Lotta Robertsson, Jason Stewart, Magnus Wahlin, Per Albertsson, Truls Råmunddal, Elmir Omerovic
Journal: Journal of the American College of Cardiology (2016)
TCT-339 Bifurcation lesions involved in the recanalization process of coronary chronic total occlusions: Incidence, treatment and clinical implications
Authors: Soledad Ojeda, Manuel Pan, Alejandro Gutierrez-Barrios, Jorge Chavarria, Miguel Romero, Laura Pardo, Javier Suárez de Lezo, Francisco Hidalgo, Francisco Mazuelos, José Segura, Francisco Carrasco, Enrique Durán, Carlos Ferreiro, José J. Sánchez, Sara Rodríguez, Manuel J. Oneto, Jose Suarez De Lezo
Journal: Journal of the American College of Cardiology (2016)