tbuckley/cabot-search huggingface dataset:
Abstract 1898: The Liverpool Lung Project risk model: An independent validation and clinical utility in primary care
Authors: John K. Field, Olaide Y. Raji, Adrian Cassidy, Stephen W. Duffy, Stuart G. Baker, David C. Christiani
Journal: Cancer Research (2011)

Abstract Background: The results from a recent CT screening trial for lung cancer showed evidence of mortality reduction in the screened arm of the study. The long term success of future National Screening Programme as an early diagnosis tool may be dependent upon identifying populations at sufficient risk of developing the disease such that the benefit:harm ratio of the intervention can be maximised. Risk prediction models can play an important role in risk stratification by providing an estimate of individual's risk of developing a disease at a future time, but require validation in independent populations before they can be successfully generalised. Within the Liverpool Lung Project (LLP), we have developed a risk prediction model for estimating individual's 5-year absolute risk of lung cancer. The model was based on five epidemiological risk factors namely smoking duration, prior diagnosis of pneumonia, family history of lung cancer, occupational exposure to asbestos and prior diagnosis of other cancer. We present here an independent validation and clinical utility of the model using data from two case-control studies and a cohort population from Europe and North America. Method: The 5-year absolute risk of lung cancer was estimated for subjects in the Harvard and European Early Lung Cancer (EUELC) case-control and LLP prospective cohort studies. The model's performance was assessed through its predictive accuracy (discrimination and calibration) and clinical utility. The area under the receiver-operator characteristic curve (AUC) measures the model's discriminatory power while calibration was assessed by comparing the observed and the expected lung cancer cases in the cohort population. The clinical relevance of the model was examined using the decision and relative utility curves. Results: There was an evidence of good discriminations in Harvard (AUC = 0.76) and LLP cohort (c-index = 0.77, 0.82) with no significant difference in discrimination by age, gender and smoking status. In general, the model calibration indicated an underestimation of absolute risk; this showed improvement with high absolute risks. The application of the model was associated with reasonably good clinical utility across the three datasets as demonstrated by its superior ‘net benefit’ against any other alternative strategy. Conclusion: The LLP risk model demonstrates good performance and evidence of clinical usefulness in three independent settings and can serve as an adjunct tool for clinicians or used in primary care for referring patients for early detection and prevention intervention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1898. doi:10.1158/1538-7445.AM2011-1898
FRI0330 Subclinical impairment of ovarian reserve in systemic lupus erythematosus patients with normal menstruation
Authors: Z. Zhan, W. Ma, D. Chen, X. Liang
Journal: Annals of the Rheumatic Diseases (2013)

<h3>ABSTRACT</h3> <h3>Context</h3> In the spring of 2020, schools closed to in-person teaching and sports were cancelled to control the transmission of CoVID-19. The changes that took place to the physical and mental health among young athletes during this time remain unknown, however. <h3>Objective</h3> Identify changes in the health (mental health, physical activity and quality of life) of athletes that occurred during the CoVID-19 pandemic. <h3>Design</h3> Cross sectional study. <h3>Setting</h3> Sample recruited via social media. <h3>Patients or Other Participants</h3> 3243 Wisconsin adolescent athletes (age=16.2±1.2 yrs., female=58% female) completed an online survey in May 2020 (DuringCoVID-19). Health measures for this cohort were compared with previously reported data for Wisconsin adolescent athletes (n=5231, age=15.7±1.2, 47% female) collected in 2016–2018 (PreCoVID-19). <h3>Main Outcome Measure(s)</h3> Demographic information included: sex, grade and sports played. Health assessments included the Patient Health Questionnaire-9 Item (PHQ-9) to identify depression symptoms, the Pediatric Functional Activity Brief Scale (PFABS) for physical activity, and the Pediatric Quality of Life Inventory 4.0 (PedsQL) for health related quality of life (HRQoL). Univariable comparisons of these variables between groups were made via t-tests or chi-square tests. Means and 95% confidence intervals (CI) for each group were estimated by survey weighted ANOVA models. <h3>RESULTS</h3> Compared to PreCoVID-19, a larger proportion of the During-CoVID-19 participants reported rates of moderate to severe levels of depression (9.7% vs 32.9%, p&lt;0.001). During-CoVID-19 participants reported 50% lower (worse) PFABS scores (mean:12.2 [95%CI: 11.9, 12.5] vs 24.7 [24.5, 24.9] p&lt;0.001) and lower (worse) PedsQL total scores compared to the PreCoVID-19 participants (78.4 [78.0, 78.8] vs. 90.9 [90.5, 91.3] p&lt;0.001). <h3>CONCLUSIONS</h3> During the CoVID-19 pandemic, adolescent athletes reported increased symptoms of depression, decreased physical activity and decreased quality of life compared to adolescent athletes in previous years. <h3>Key points</h3> Adolescent athletes during CoVID-19 were three times more likely to report moderate to severe symptoms of depression compared to data collected prior to CoVID-19. Adolescent athletes during CoVID-19 reported significantly lower physical activity and quality of life scores compared to high school athletes prior to the CoVID-19 pandemic Post CoVID-19 policies should be implemented to improve the health of adolescent athletes in the US.
Treatment of leukemic relapse after allogeneic stem cell transplantation with cytotoreductive chemotherapy and/or immunotherapy or second transplants
Authors: F Keil, E Prinz, P Kalhs, K Lechner, K Moser, I Schwarzinger, U Jäger, C Fonatsch, N Worel, C Mannhalter, W Rabitsch, H Loidolt, A Schulenburg, M Mitterbauer, P Höcker, HT Greinix
Journal: Leukemia (2001)
P948 TERLIPRESSIN INDUCES HYPONATREMIA IN A SUBGROUP OF CIRRHOTIC PATIENTS WITH ACUTE VARICEAL BLEEDING OR HEPATORENAL SYNDROME AND IS ASSOCIATED WITH IMPROVED CLINICAL OUTCOME
Authors: M. Nguyen-Tat, E. Götz, J. Heeren, V. Sivanathan, P. Ploch, D. Sollinger, M. Wörns, P.R. Galle, J.U. Marquardt
Journal: Journal of Hepatology (2014)
Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia
Authors: AG Bosanquet, I Sturm, T Wieder, F Essmann, MI Bosanquet, DJ Head, B Dörken, PT Daniel
Journal: Leukemia (2002)
Winning Their Trust
Authors: Anand K. Parekh
Journal: New England Journal of Medicine (2011)

The ranks of the U.S. medical profession will soon grow by 16,000 physicians, as the class of 2011 graduates from medical schools throughout the country. These new physicians will go on to receive graduate medical training that is superb by global standards. Once in practice, they will be encouraged to uphold high quality standards through licensing and certification, activities of specialty societies, and participation in a growing array of incentive programs (e.g., quality-measure reporting, meaningful use of information technology, and care models fostering enhanced communication and coordination of care).All this emphasis on the quality of care aims to maximize . . .
High Frequency of BRCA1 Founder Mutations in the Bahamas.
Authors: T. Donenberg, J. Lunn, T. Turnquest, D. Curling, E. Krill-Jackson, R. Royer, S. Narod, J. Hurley
Journal: Cancer Research (2009)

Abstract The frequency of mutations in the BRCA1 and BRCA2 genes differs among ethnic groups, due to regional founder effects. The Bahamas is an island nation of 305,000 people, with a complex history of immigration from the 1600s-1800s including English, Americans and African slaves. An initial survey by our group demonstrated that 48% of breast cancers in the Bahamas are diagnosed in women under 50 suggesting an inherited cause for many. In a follow up study, we identified four distinct BRCA1 mutations in 9 of 19 high risk Bahamian breast and ovarian cancer families (47.36%). A fifth mutation has been previously published in a Bahamian family and is a confirmed African founder mutation. In the current study, we sought to estimate the prevalence of these mutations among unselected breast and ovarian cancer patients from the Bahamas. We have enrolled 135 unrelated women with breast (n = 133) or ovarian cancer (n=2) attending public and private clinics in the Bahamas and Miami. A detailed family history was obtained from each patient and a saliva sample was obtained for DNA analysis. DNA samples were tested by mutation specific assay for the presence of five BRCA1 mutations (IVS13+1G&amp;gt;A, M1775R, IVS16+6A&amp;gt;C, 4730insG and 943ins10). Twenty-three mutations were detected, representing 17% mutation prevalence in this population, including IVS13+1G&amp;gt;A (14 times), IVS16+6A&amp;gt;C (two times), M1775R (three times), 4730insG (three times) and 943ins10 (once). This reflects a very high rate of genetic breast cancer in this population with a strong founder effect. This important finding raises the possibility of developing an inexpensive genetic screen for inherited susceptibility to breast cancer in the Bahamas and the need to mount an effective cancer prevention strategy for this population at high risk. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4078.
A hippocampal indexing model of memory retrieval based on state trajectory reconstruction
Authors: Peter Ford Dominey
Journal: Behavioral and Brain Sciences (2013)

Abstract A method is proposed where static patterns or snapshots of cortical activity that could be stored as hyperassociative indices in hippocampus can subsequently be retrieved and reinjected into the neocortex in order to enable neocortex to then proceed to unfold the corresponding sequence, thus implementing an index-based sequence memory storage and retrieval capability.
The development and clinical evaluation of a ‘traffic-light’ design dermatology outpatient discharge information checklist
Authors: N.A. Harun, A.Y. Finlay, M. Salek, V. Piguet
Journal: British Journal of Dermatology (2016)

Although multiple factors influence discharge decisions, there is no structured guidance to assist clinicians in making informed decisions. A discharge information checklist might improve the appropriateness of dermatology clinicians' discharge decisions. To generate consensus among dermatologists on the content of an outpatient discharge checklist, to create one and to seek clinicians' opinions on its usefulness. Seventeen consultant dermatologists from five National Health Service trusts completed a 72‐item Delphi questionnaire. A five‐point Likert scale was used to rate each item for importance in contributing to a high‐quality discharge decision. Eighteen clinicians completed a questionnaire evaluating checklist use. Consensus was determined when ≥ 75% of consultants rated an item 'very important' or 'important'. There was strong inter‐rater reliability (intraclass correlation coefficient = 0·958) and fair inter‐rater agreement (Fleiss kappa = 0·269). There were 26 consensus‐agreed items, condensed to 13 that formed the 'traffic‐light' checklist. These are disease‐related issues (diagnostic certainty, disease severity, treatment appropriateness, patient manageable in primary care, patient's benefit from follow‐up), patient empowerment issues (understanding diagnosis and treatment outcome, having a clear plan, treatment side‐effects, ability to self‐manage) and addressing concerns (patient concerns, easy reaccess to secondary care, whether patient and clinician are happy with the decision). Twelve clinicians (67%) found the checklist useful, 11 (61%) wanted to use it in future, 10 (56%) thought it was useful for training and three (17%) said it helped their thinking. Clinicians suggested its use for auditing and for training clinicians and administrators. Items were identified to create an outpatient discharge information checklist, which demonstrated high acceptability.
It's Not Easy Being Green: Chlorophyll Being Tested
Authors: J. Ziegler
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article It's Not Easy Being Green: Chlorophyll Being Tested Get access Jan Ziegler Jan Ziegler Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 1, 4 January 1995, Page 11, https://doi.org/10.1093/jnci/87.1.11 Published: 04 January 1995
Abstract 4989: FLIP transcriptional deregulation: A potential mechanism for development of androgen independent prostate cancer
Authors: Jianping Xie, Rita Ghosh, Addanki P. Kumar
Journal: Cancer Research (2010)

Abstract The cellular Fas/FasL-associated death domain protein-like inhibitory protein (c-FLIP) plays a critical role in the regulation of apoptosis. Studies from our laboratory identified transcription factor Sp1 as an activator and Sp3 as an inhibitor of Sp1 transactivation of FLIP in prostate cancer cells. We have also shown that inhibition of FLIP by 2-methoxyestradiol (2-ME2) (i) induces apoptosis in prostate cancer cells and (ii) is associated with regression of prostate tumors in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. In addition FLIP promoter contains putative binding sites for various transcription factors including AP-1, c-Myc, NFκB, ARE (androgen response element) and p53, it is possible that these elements alone or through cooperative interactions may be important for the regulation of FLIP transcription and also in mediating 2-ME2 induced apoptosis. The present study was carried out to investigate the role of androgens in the transcriptional regulation of the FLIP using deletion analysis coupled with chromatin immunoprecipitation assay (ChIP), electrophoretic mobility shift assay (EMSA) and transient expression assays in prostate cancer cells. Our results show that treatment of androgen responsive LNCaP cells with DHT stimulates (i) cell proliferation; (ii) FLIP transcriptional activity; (iii) Sp1 and ARE DNA binding activity; (iv) PSA transcriptional activity and treatment with 2-ME2 inhibited the observed DHT-stimulated activities. Our findings suggest that although the FLIP promoter binds multiple nuclear proteins, Sp1 or a related protein appears to be a critical determinant of FLIP transcription, possibly through cooperative interactions between Sp1 and additional transcription factors including AR. Supported by ACS RSG-04-169 and NIH CA 135451 (APK). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4989.
Retraction: Barbaro et Al. Incidence of Dilated Cardiomyopathy and Detection of HIV in Myocardial Cells of HIV-Positive Patients. N Engl J Med 1998;339:1093-9.
Authors: Jeffrey M. Drazen, Gregory D. Curfman
Journal: New England Journal of Medicine (2002)

It was brought to our attention that Figure 1 in a 1990 article by Grody and coworkers, 1 when printed as displayed below (in black and white, inverted top to bottom and side to side), is strikingly similar (except for the in situ hybridization signal) to Figure 2 below, which appeared in an article by Barbaro et al. that we published in 1998. 2 We contacted the corresponding authors of both articles.
Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study
Authors: Daniel Levy, Robert J. Garrison, Daniel D. Savage, William B. Kannel, William P. Castelli
Journal: New England Journal of Medicine (1990)

A pattern of left ventricular hypertrophy evident on the electrocardiogram is a harbinger of morbidity and mortality from cardiovascular disease. Echocardiography permits the noninvasive determination of left ventricular mass and the examination of its role as a precursor of morbidity and mortality. We examined the relation of left ventricular mass to the incidence of cardiovascular disease, mortality from cardiovascular disease, and mortality from all causes in 3220 subjects enrolled in the Framingham Heart Study who were 40 years of age or older and free of clinically apparent cardiovascular disease, in whom left ventricular mass was determined echocardiographically.
Dwarfism in Healthy Children: Its Possible Relation to Emotional, Nutritional and Endocrine Disturbances
Authors: Nathan B. Talbot, Edna H. Sobel, Bertha S. Burke, Erich Lindemann, Shirley B. Kaufman
Journal: New England Journal of Medicine (1947)

CHILDREN in good health who are receiving an adequate diet tend to follow a relatively standard pattern of growth and maturation. Although moderate deviations from the average trend are commonly considered to be normal physiologic variations, extreme deviations suggest that some abnormality exists. In the past few years more than 100 abnormally short children have been encountered in the pediatric clinics of this hospital. In approximately 50 per cent of these patients the stunted growth could be related to a definite disturbance in the pulmonary, cardiovascular, gastrointestinal, renal, hepatic, skeletal or endocrinologic system. There remained, however, a group of 28 . . .
Acid Secretion after Calcium Carbonate in Patients with Duodenal Ulcer
Authors: Robert F. Barreras
Journal: New England Journal of Medicine (1970)

Gastric secretion after antacid ingestion was measured in a randomized double-blind study of 20 men with duodenal-ulcer disease. Four equivalent neutralizing doses of calcium carbonate, sodium bicarbonate and magnesium hydroxide were given hourly in the fasting state. In the third hour after calcium carbonate the acid output (mean ± S.E.M.) was 11.4 ± 1.8 mEq per hour. After sodium bicarbonate it was 5.6 ± 1.0 and after magnesium hydroxide 6.1 ± 1.1 mEq. Morning basal acid output was 5.3 ± 1.8 mEq. In addition to the twofold increase in acid output, significant increases in the acidity of the gastric juice and in the serum calcium were observed. The calcium carbonate itself, rather than a nonspecific action of antacids, appears to be responsible for the effects noted.
Squamous Cell Carcinoma of the Bulbar Conjunctiva Seen on F-18 FDG PET/CT
Authors: Amir G. Abdelmalik, Patricio Fajnwaks, Medhat M. Osman, Nghi C. Nguyen
Journal: Clinical Nuclear Medicine (2010)

A 65-year-old man with left orbital mass and recent vision loss underwent FDG PET/CT, which showed intensely FDG-avid anterior left orbital mass invading the periorbital soft tissue. Enlarged left retromandibular, mediastinal, and abdominal lymph nodes with intense FDG uptake were suspicious for malignancy. Left orbital exenteration revealed moderately differentiated squamous cell carcinoma. Fine needle aspiration of mediastinal lymph nodes revealed inflammatory processes; therefore, the left retromandibular lymph node was felt to be benign and no biopsy was performed. However, follow-up PET/CT demonstrated significant increase in size and uptake of the left retromandibular lymph node, which was proven metastatic in subsequent biopsy.
Kidney Transplantation in Fanconi Syndrome
Authors: William A. Briggs, Namiko Kominami, Richard E. Wilson, John P. Merrill
Journal: New England Journal of Medicine (1972)

KIDNEY transplantation in children and adolescents with end-stage renal disease will provide information regarding the possibility of recurrence in the transplanted kidney of diseases unique to children. This report presents the contrasting post-transplant courses of two patients with the Fanconi syndrome, one with the idiopathic variety and the other with cystinosis.Case ReportsCase 1. A 14-year-old boy was found to have idiopathic Fanconi syndrome at the age of 5. Progressive renal insufficiency ensued, requiring hemodialysis in 1968. Ophthalmologic and bone-marrow examinations were negative for cystine, as were the kidneys after nephrectomy.In May, 1969, he received a maternal renal . . .
217 HIGH RETICULOCYTE COUNT PREDICTS MORTALITY AND IMPROVES ACCURACY OF UKELD IN PATIENTS AWAITING LIVER TRANSPLANTATION
Authors: R. Parker, M.J. Armstrong, I.A.C. Rowe, C. Corbett, B. Stephenson, J. Hodson, D.D. Houlihan, J.W. Ferguson
Journal: Journal of Hepatology (2012)
Abstract 2989: Loss of methylation in a regulatory region of BCL2 in MDS/AML.
Authors: Sangmin Lee, Naomi Galili, Stephen Nimer, Mark D. Minden, Vundavalli V. Murty, Suresh Jhanwar, Azra Raza, Benjamin Tycko
Journal: Cancer Research (2013)

Abstract Background: Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis and increased risk of progression to acute myeloid leukemia (AML). A hallmark of MDS is increased apoptosis, while AML undergoes decreased apoptosis and increased proliferation. BCL2, an anti-apoptotic protein, is overexpressed in high grade MDS and AML and may confer poor prognosis and increased chemotherapy resistance. In this study we examined the DNA methylation status of BCL2 in MDS and AML. Methods: We conducted DNA methylation profiling on genomic DNA extracted from bone marrows of 22 refractory anemia with ringed sideroblasts (RARS), 8 refractory anemia with excess blasts (RAEB), 21 de novo AML, 21 therapy related AML, and 7 normal volunteers. We used both Illumina 27K BeadChip and 450K BeadChip methylation arrays to assess CpG methylation. Standard student T-test was used to screen differentially methylated MDS and AML CpG sites compared to normal samples. We validated the microarray data by combined bisulfite restriction analysis (COBRA) and bisulfite sequencing. Results: We identified a region in the BCL2 gene body that was among the most differentially methylated in MDS and AML versus normal bone marrow. Within that amplicon, BCL2 in both RARS, a low grade MDS, and RAEB, a high grade MDS, were hypermethylated compared to normal bone marrow (43% vs 18%, 48% vs 18%, respectively, p&amp;lt;0.05). BCL2 in de novo AML and therapy related AML were hypomethylated compared to normal bone marrow (12% vs 35%, 13% vs 35%, respectively, p&amp;lt;0.05). We validated these results by COBRA and bisulfite sequencing. This region coincided with H3K27ac and H3K4m1 enhancer type marks in ENCODE data in normal cells. Conclusions: Our study identifies a region of BCL2 that is hypermethylated in both low and high risk MDS while hypomethylated in AML compared to normal bone marrows. We hypothesize aberrant epigenetic modification of BCL2 plays a key role in apoptosis and transformation from MDS to AML, and our data support the idea of combining demethylating drugs with BCL2 antagonists. We are currently investigating whether BCL2 protein expression correlates with methylation, and plan to map the histone marks with CHIP-seq to correlate chromatin accessibility and DNA methylation in BCL2. Citation Format: Sangmin Lee, Naomi Galili, Stephen Nimer, Mark D. Minden, Vundavalli V. Murty, Suresh Jhanwar, Azra Raza, Benjamin Tycko. Loss of methylation in a regulatory region of BCL2 in MDS/AML. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2989. doi:10.1158/1538-7445.AM2013-2989