tbuckley/cabot-search huggingface dataset:
Shoulder anatomy defined by a Tc-99m leukocyte study.
Authors: LOUISE J. THOMSON, ROBERT BREIT, KEVIN ALLMAN, HANS VAN DER WALL
Journal: Clinical Nuclear Medicine (2001)

J. THOMSON, LOUISE E. M.B.CH.B., F.R.A.C.P.,*; BREIT, ROBERT M.B.B.S., F.R.A.C.S., F.A. ORTH.A.,†; ALLMAN, KEVIN C. M.B.B.S., F.R.A.C.P.,*; VAN DER WALL, HANS M.B.B.S., Ph.D., F.R.A.C.P.* Author Information
SAT0582 Psoriasis Symptom Inventory is a Valid Patient-Reported Instrument for the Assessment of Skin Severityin Psoriatic Arthritis
Authors: S.Z. Aydın, B. Yılmazer, Ö. Bayındır, K. Aksu, E. Dalkılıç, M.F. Öksüz, E.F. Tarhan, M. Can, O. Küçükşahin, G. Kimyon, L. Akyol, A.M. Onat, B. Kısacık, A. Erden, A. Omma, E.D. Ersözlü Bozkırlı, C. Özişler, E. Gönüllü, D. Solmaz, M. Çınar, G. Yıldırım Çetin, M. Aydın Tufan, L. Kılıç, S. Erten, T. Kaşifoğlu, S. Akar, E. Kasapoğlu Günal, F. Erbasan, F. Yıldız, Y. Kabasakal, U. Kalyoncu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Skin involvement in psoriatic arthritis (PsA) has significant impacts on health-related quality of lives in addition to the joint involvement. Due to this impact, it9s important to assess the severity of psoriasis to fully capture disease activity in PsA. In this study we aimed to test the validity of “Psoriasis symptom inventory” (PSI) in a cohort of patients with PsA. <h3>Methods</h3> PsART (Psoriatic Arthritis Registry of Turkey) is a prospective, multicentre, nationwide study in Turkey on patients with PsA. Patients are consecutively recruited to this registry, if they are diagnosed as PsA, regardless of any other disease characteristics. In this registry, PSI data was available in 237 patients. For the PSI the following items were scored on a scale between 0-4, by the patient: itching, redness, scaling, burning, stinging, cracking,flaking and pain. The PSI score was calculated as a sum of these items and ranged between 0-32. The correlations between PSI and other outcome measures were investigated. <h3>Results</h3> The mean (SD) age and BMI were 44.7 (12.3) and 28.7 (5.6), respectively. Sixty-six percent of the patients were female. The duration of psoriasis in this group was 167.3 (124.2) months. Mean (SD) PSI scores were 6.7 (6.7) with a range of 0-32. PSI scores were found to be significantly correlated to patient (R=0.338) and physician global assessments (R:0.342), fatique (R=0.226), pain (R=0.334) (p&lt;0.001 for all comparisons) and HAQ (R=0.198; p=0.007). PSI was also correlated to body surface area involved, measured by the physician (R=0.256, p=0.07). <h3>Conclusions</h3> PSI has a good construct validity in comparison to other clinical assessment tools. Due to its high feasibility, PSI can be a useful tool to investigate and record the severity of psoriasis in PsA in clinical practice. <h3>Disclosure of Interest</h3> None declared
OP18LONG TERM OUTCOMES OF SKULL-BASE LOW-GRADE CHONDROSARCOMA PATIENTS TREATED WITH PENCIL BEAM SCANNING PROTON THERAPY AT THE PAUL SCHERRER INSTITUTE
Authors: Damien Charles Weber, Shahed Badiyan, Tony Lomax, Robert Malyapa, Alessandra Bolsi, Francesca Albertini, Ralf Schneider
Journal: Neuro-Oncology (2015)

INTRODUCTION: Skull-base chondrosarcoma (ChSa) are rare malignant bone tumors. The current study was performed to evaluation the safety and effectiveness of pencil beam scanning proton therapy (PT) as well as prognostic factors in patients with skull base low-grade ChSa. METHOD: Between October 1998 and September 2014, 77 (male, 46%) patients with histologically confirmed low-grade ChSa were treated at the PSI. Median age was 38.9 years (range, 10.2-70.0). PT was delivered at initial diagnosis post-operatively to 62 (80.5%) patients. Median administered dose was 70.0 GyRBE (range, 64.0-76.0). Local control (LC), overall survival (OS) and toxicity-free survival (TFS) rates were calculated using the Kaplan Meier method. Toxicity was assessed according to the CTCAE v.4.0 scale. RESULTS: After a median follow-up of 58.2 (range, 4.6-190.8) months, 6 local (7.8%) failures were observed. The median time to local failure was 28.4 (range, 11.7-140.8) months. Five (6.5%) patients died. The actuarial 8-year LC and OS were 89.7% and 93.5%, respectively. High-grade (≥3) radiation induced toxicity was observed in 6 (7.8%) patients. Three (3.9%) patients presented with grade 3 hearing loss, 2 (2.6%) patients with grade 4 cerebellum or spinal cord necrosis and one (1.3%) patient with grade 4 optic neuropathy. The 8-year high-grade TFS was 90.8%. The univariate analysis (LC) results will be presented during the congress. CONCLUSION: This is the largest PBS PT series reporting the outcome of patients with low-grade ChSa of the skull of base. Our data indicates that protons are both safe and effective. Despite the high-dose administered to these patients, only a minority of patients of patients developed clinically significant toxicity.
Conditioning of the Host&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;
Authors: Helene Wallace Toolan, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Conditioning of the Host Get access Helene Wallace Toolan, Ph.D. Helene Wallace Toolan, Ph.D. Sloan-Kettering Institute, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 745–767, https://doi.org/10.1093/jnci/14.3.745 Published: 01 December 1953
Finding for Uterine Cancer From One or More Cytologic Examinations of 33,750 Women
Authors: John E. Dunn, Jr., M.D., Thomas A. Slate, M.D., John W. Merritt, B.S., Purvis L. Martin, M.D.
Journal: JNCI Journal of the National Cancer Institute (1959)

Results for cervical cancer are reported from the cytologic examination of 33,750 women. Of these women 9,837 had a second examination, 4,244 a third, 1,662 a fourth, and 450 had from 5 to 10 periodic examinations. These findings and those from 3 other studies that provided age-specific prevalence rates for carcinoma in situ and invasive cervical cancer are compared. The age-specific prevalence rates for carcinoma in situ in all studies hit a peak somewhere in the 30 to 49-year-age range; are depressed somewhere in the 40 to 59-year-age range; and then rise again for older women. The possible meaning of the middle-aged depression of these rates regarding spontaneous regression of carcinomas in situ is discussed. In the periodic examination of women previously cytologically negative, those with class 2 cytology have about 10 times the potentiality in the next year for carcinoma in situ compared to those previously of class 1. There appears to be an extensive annual turnover of those cytologically of class 2 back to class 1, and replacement by women moving from class 1 to class 2 cytology. The cancer probability for other positive cytology classes is presented. The pattern of age-specific prevalence rates suggests that carcinoma in situ has a longer duration on the average when arising in younger women than in older women. The rates for the invasive stage do not suggest this for the invasive stage of the disease.
Studies on the Anemia of Tumor-Bearing Animals. III. Localization of Erythrocyte Iron Within the Tumor
Authors: Vincent E. Price, Robert E. Greenfield, William R. Sterling, Ross C. MacCardle
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Studies on the Anemia of Tumor-Bearing Animals. III. Localization of Erythrocyte Iron Within the Tumor Get access Vincent E. Price, Vincent E. Price Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert E. Greenfield, Robert E. Greenfield Search for other works by this author on: Oxford Academic PubMed Google Scholar William R. Sterling, William R. Sterling Search for other works by this author on: Oxford Academic PubMed Google Scholar Ross C. MacCardle Ross C. MacCardle Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 22, Issue 5, May 1959, Pages 877–884, https://doi.org/10.1093/jnci/22.5.877 Published: 01 May 1959 Article history Received: 06 January 1959 Published: 01 May 1959
Mitochondrial Transplantation Attenuates Airway Hyperresponsiveness by Inhibition of Cholinergic Hyperactivity
Authors: Yuan Su, Liping Zhu, Xiangyuan Yu, Lei Cai, Yankai Lu, Jiwei Zhang, Tongfei Li, Jiansha Li, Jingyan Xia, Feng Xu, Qinghua Hu
Journal: Theranostics (2016)

Increased cholinergic activity has been highlighted in the pathogenesis of airway hyperresponsiveness, and alternations of mitochondrial structure and function appear to be involved in many lung diseases including airway hyperresponsiveness.It is crucial to clarify the cause-effect association between mitochondrial dysfunction and cholinergic hyperactivity in the pathogenesis of airway hyperresponsiveness.Male SD rats and cultured airway epithelial cells were exposed to cigarette smoke plus lipopolysaccharide administration; mitochondria isolated from airway epithelium were delivered into epithelial cells in vitro and in vivo.Both the cigarette smoke plus lipopolysaccharide-induced cholinergic hyperactivity in vitro and the airway hyperresponsiveness to acetylcholine in vivo were reversed by the transplantation of exogenous mitochondria.The rescue effects of exogenous mitochondria were imitated by the elimination of excessive reactive oxygen species or blockage of muscarinic M 3 receptor, but inhibited by M receptor enhancer.Mitochondrial transplantation effectively attenuates cigarette smoke plus lipopolysaccharide-stimulated airway hyperresponsiveness through the inhibition of ROS-enhanced epithelial cholinergic hyperactivity.
A Case–Control Study of Prenatal Thallium Exposure and Low Birth Weight in China
Authors: Wei Xia, Xiaofu Du, Tongzhang Zheng, Bin Zhang, Yuanyuan Li, Bryan A. Bassig, Aifen Zhou, Youjie Wang, Chao Xiong, Zhengkuan Li, Yuanxiang Yao, Jie Hu, Yanqiu Zhou, Juan Liu, Weiyan Xue, Yue Ma, Xinyun Pan, Yang Peng, Shunqing Xu
Journal: Environmental Health Perspectives (2015)

BackgroundThallium (Tl) is a highly toxic heavy metal widely present in the environment. Case reports have suggested that maternal exposure to high levels of Tl during pregnancy is associated with low birth weight (LBW), but epidemiological data are limited.ObjectivesThis study was designed to evaluate whether prenatal Tl exposure is associated with an increased risk of LBW.MethodsThis case–control study involving 816 study participants (204 LBW cases and 612 matched controls) was conducted in Hubei Province, China, in 2012–2014. Tl concentrations were measured in maternal urine collected at delivery, and associations with LBW were evaluated using conditional logistic regression.ResultsHigher maternal urinary Tl levels were significantly associated with increased risk of LBW [crude odds ratio (OR) = 1.52; 95% CI: 1.00, 2.30 for the highest vs. lowest tertile], and the association was similarly elevated after adjustment for potential confounders (adjusted OR = 1.90; 95% CI: 1.01, 3.58 for the highest vs. lowest tertile). Stratified analyses showed slightly higher risk estimates for LBW associated with higher Tl levels for mothers < 28 years old and for mothers with lower household income; however, there was no statistical evidence of heterogeneity in risk according to maternal age (p for heterogeneity = 0.18) or household income (p for heterogeneity = 0.28).ConclusionTo our knowledge, ours is the first case–control study to investigate the association between prenatal Tl exposure and LBW. The results suggest that prenatal exposure to high levels of Tl may be associated with an increased risk of LBW.CitationXia W, Du X, Zheng T, Zhang B, Li Y, Bassig BA, Zhou A, Wang Y, Xiong C, Li Z, Yao Y, Hu J, Zhou Y, Liu J, Xue W, Ma Y, Pan X, Peng Y, Xu S. 2016. A case–control study of prenatal thallium exposure and low birth weight in China. Environ Health Perspect 124:164–169; http://dx.doi.org/10.1289/ehp.1409202
Vector-related risk mapping of the introduction and establishment of Aedes albopictus in Europe
Authors: M Straetemans, None on behalf of the ECDC consultation
Journal: Eurosurveillance (2008)

Chikungunya fever is a viral disease transmitted by Aedes spp mosquitoes [1]. In recent years, several outbreaks have been reported in Kenya (2004), the Comoros Islands (2005), the island of Réunion (2005, 2006), other islands in the southwest Indian Ocean (2005) and in India (2005-2006) [2,3], during which Ae. aegypti and/or Ae. albopictus were the main vectors [1]. .
Final analysis of a phase II study of modified FOLFIRINOX in locally advanced and metastatic pancreatic cancer.
Authors: Stacey Stein, Edward Samuel James, Xiangyu Cong, Yanhong Deng, Ronald R Salem, Charles Cha, Bryan William Chang, Howard S. Hochster, Indukala Doddamane, Annmarie Boustani, Vatsal Patel, Jeremy S. Kortmansky, Jia Li, Carol Staugaard, Jill Lacy
Journal: Journal of Clinical Oncology (2016)

395 Background: Toxicities associated with FOLFIRINOX have prompted use of modifications, despite absence of prospective data validating comparable efficacy and improved tolerability. To determine the impact of attenuated doses of irinotecan and bolus 5FU on efficacy and tolerability, we conducted a prospective phase II study of modified FOLFIRINOX in advanced PC. The efficacy of a FOLFIRINOX regimen has not been previously examined in locally advanced PC (LAPC). Previous studies in LAPC have compared chemo vs chemoRT with median OS in the 9-12 mo range (Loehrer et al, Chauffert et al, Hammel et al). Methods: Previously untreated pts with MPC or LAPC received modified FOLFIRINOX with pegylated filgrastim. Irinotecan and bolus FU were reduced by 25%. AEs were compared to historical control (Conroy et al NEJM 2011). Objective RR in MPC was compared to historical control. PFS and OS were calculated for both cohorts. Results: 31 and 44 pts with LAPC and MPC enrolled. Treatment-related grade 3 and 4 AEs were diarrhea (16.2%), neutropenia (12.2%), fatigue (12.2%), thrombocytopenia (9.5%), anemia (5.4%). Neutropenia (p &lt; 0.0001), vomiting (p = 0.001), and fatigue (p = 0.01) were significantly decreased compared to historical control patients. In MPC, the RR (35.1%) was similar to the historical control group (36.3%; p 0.82); median PFS and OS were 6.1 months (95% CI, 5.19 to 8.31) and10.2 months (95% CI, 7.65 to 14.32) respectively. In LAPC, the RR was 17.2% and median PFS and OS were 17.8 mo (95% CI, 11.0 to 23.9) and 26.6 mo (95% CI, 16.7, NA) respectively. 13 pts went on to surgical resection with 10 now alive and 6 without recurrence. We found no significant association between early metabolic response by FDG-PET imaging and PFS and OS. Conclusions: In this first prospective study of modified FOLFIRINOX, the regimen was well tolerated and associated with decreased incidence of AEs compared to historical control of standard FOLFIRINOX. In MPC pts, the efficacy of the modified regimen appear uncompromised. In this first prospective study of a FOLFIRINOX regimen in LAPC, the PFS and OS surpasses that of previously studied regimens in LAPC. Clinical trial information: NCT01523457.
Medicaid
Authors: John K. Iglehart
Journal: New England Journal of Medicine (1999)

Medicaid is the largest health insurer in the United States, in terms of eligible beneficiaries, covering medical services and long-term care for some 41.3 million people. In 1997, Medicaid expended $159.9 billion (12.4 percent of total national health care expenditures) to pay for covered services for low-income people who were elderly, blind, disabled, receiving public assistance, or among the working poor. The vast majority of such persons fall outside the employment-based insurance system, the mainstay of coverage for the working population. This fifth report in the series on the American health care system14 examines the federal and state roles . . .
The Glutamyltransferase Activity of Normal and Neoplastic Tissues
Authors: Leon Levintow
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article The Glutamyltransferase Activity of Normal and Neoplastic Tissues Get access Leon Levintow Leon Levintow National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 347–352, https://doi.org/10.1093/jnci/15.2.347 Published: 01 October 1954 Article history Received: 30 June 1954 Published: 01 October 1954
Association of Alterations in Gray Matter Volume With Reduced Evoked‐Pain Connectivity Following Short‐Term Administration of Pregabalin in Patients With Fibromyalgia
Authors: Tudor Puiu, Anson E. Kairys, Lynne Pauer, Tobias Schmidt‐Wilcke, Eric Ichesco, Johnson P. Hampson, Vitaly Napadow, Daniel J. Clauw, Richard E. Harris
Journal: Arthritis & Rheumatology (2016)

Pregabalin (PGB) is an α2 δ calcium-channel subunit ligand that has previously been shown to reduce chronic pain in multiple conditions. Preclinical studies indicate that PGB may down-regulate brain glutamate release while also inhibiting astrocyte induction of glutamatergic synapse formation, and recent clinical findings support the notion that PGB modulates glutamatergic activity and functional brain connectivity in order to produce analgesia. The present study was undertaken to examine concurrent changes in brain gray matter volume (GMV) or evoked-pain connectivity in humans receiving PGB.Sixteen female fibromyalgia patients participated in a randomized double-blind 2-period crossover study of PGB versus placebo. Before and after each period, patients underwent high-resolution structural and evoked pressure-pain functional brain imaging. GMV was analyzed using voxel-based morphometry, and functional connectivity during evoked pressure-pain was assessed.PGB administration significantly reduced GMV within the posterior insula bilaterally, whereas there were no significant changes in insular GMV following placebo treatment. GMV reductions in the medial frontal gyrus were also observed when comparing PGB versus placebo treatment, and were associated with reduced clinical pain. These reductions in insular GMV were associated with concomitant reductions in connectivity to the default mode network, which was also associated with reduced clinical pain.Short-term PGB treatment altered brain structure and evoked-pain connectivity, and these decreases were associated with reduced clinical pain. We speculate that these fairly rapid changes in GMV may be related to brain neuroplasticity. It is unknown whether these effects are generalizable to other chronic pain states.
FRI0427 Clinical Outcomes of Acute Transverse Myelitis in Patients with Systemic Lupus Erythematosus
Authors: S.M. Ahn, Y.-G. Kim, S. Hong, S.-H. Bae, D.-H. Lim, C.-K. Lee, B. Yoo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Acute transverse myelitis (ATM) is a severe complication of systemic lupus erythematosus (SLE). The prompt diagnosis and aggressive treatment should be followed because it often results in severe neurological sequelae. However, a little has been established the factors related with prognosis of ATM in SLE patients due to great rarity. <h3>Objectives</h3> The aim of this study is to evaluate the clinical manifestations and factors related with outcome in patients with SLE-associated ATM. <h3>Methods</h3> The retrospective analysis included 16 patients who were diagnosed with SLE-associated ATM at a single tertiary hospital from January 1995 to June 2014. The clinical characteristics, laboratory indices including cerebrospinal fluid (CSF), and radiologic image of the spine were obtained from the electronic medical records. The patients were divided into two groups based on improvement of neurologic deficits after treatments: 1) Non-responder and 2) Responder (completely or partially). <h3>Results</h3> The median age at ATM onset was 33.5 years (IQR; 26.5-48.75) and 14 (87.5%) patients were female. The average follow-up duration after ATM onset was 74 months (range: 6-185 months). ATM was the first manifestation of SLE in 8 (50%). Parasthesia was found in 14 patients, motor weakness in 15, and autonomic dysfunction in 10. All patients started initially with high dose intravenous methylprednisolone (1mg/kg/day) therapy. And 14 (87.5%) and 9 (56.3%) were treated additionally with methylprednisolone pulse therapy (500mg/day–1000mg/day) and cyclophosphamide pulse therapy (500mg/m<sup>2</sup>). Consequentially, 12 (75%) patients recovered completely or partially (responder) and 4 (25%) persisted neurologic deficits (non-responder). Compared to responders, higher SLEDAI scores and lower complement levels were found in non-responders. Among 12 responders, five patients (36.4%) experienced at least one recurrence of ATM (range: 2-68 months after first episode). Compared to non-recurrent patients, CSF protein level was lower (36.2±11.2 vs. 122.7±89.5 mg/dL, p=0.032) and duration of high dose corticosteroid treatment was shorter (17.2±12.0 vs. 31.7±10.3 days, p=0.048) in the recurrent patients. <h3>Conclusions</h3> Our results suggest that adequate intensity of steroid therapy should be considered initially in SLE-associated ATM to obtain favorable outcome. <h3>Disclosure of Interest</h3> None declared
AIDS trends in Europe: decrease in the west, increase in the east
Authors: F Hamers, A M Downs, J Alix, J B Brunet
Journal: Eurosurveillance (1997)

In 1996, 24 920 AIDS cases were reported in the WHO European Region, bringing the cumulative total to 185 808 cases including 6969 (4%) paediatric cases (<13 years). For the first time since the start of the epidemic, the annual number of cases reported d
A Prospective Multicenter Study Of The Bruton’s Tyrosine Kinase Inhibitor Ibrutinib In Patients With Relapsed Or Refractory Waldenstrom’s Macroglobulinemia
Authors: Steven Peter Treon, Christina K Tripsas, Guang Yang, Yang Cao, Lian Xu, Zachary Hunter, Steven J Cropper, Patrick Mostyn, Kirsten Meid, Diane Warren, Christopher Patterson, Gaurav Varma, Jacob P. Laubach, Claudia E. Paba-Prada, Janet Kunsman, Irene M. Ghobrial, Sandra Kanan, Ranjana H. Advani, Maria Lia Palomba
Journal: Blood (2013)