tbuckley/cabot-search huggingface dataset:
Chronic alcoholism and male sexual function
Authors: R C Schiavi, B B Stimmel, J Mandeli, D White
Journal: American Journal of Psychiatry (1995)

The relation between chronic alcohol abuse and male sexuality remains uncertain. This study assessed the effect of chronic alcoholism on sexual function, marital adjustment, sleep-related erections, sleep disorders, and hormone levels during abstinence from alcohol.Twenty chronically alcoholic men, aged 28-59 years, without evidence of severe hepatic disease and free from unrelated medical illnesses, were assessed 2-36 months after achieving sobriety and compared to a group of 20 nonalcoholic volunteers. Each subject and his sexual partner underwent semistructured interviews and completed several questionnaires; the men had medical and psychiatric evaluations and polygraphic assessment of sleep parameters and nocturnal penile tumescence during 4 nights, with the last night devoted to sequential blood sampling for evaluation of hormone levels.The alcoholic men did not differ from the comparison group in any sexual dimension or in the prevalence of sexual problems despite the significant marital dissatisfaction reported by their sexual partners. In addition, there were no differences between groups in sleep and nocturnal penile tumescence measures. The alcoholic group had a greater prevalence of periodic leg movement disorders but no respiratory abnormalities during sleep. Except for a significant overnight increase in plasma luteinizing hormone in the alcoholic men, there were no differences between groups in total and bioavailable testosterone, dihydrotestosterone, and prolactin or in the nocturnal circadian changes in testosterone and prolactin levels.These findings suggest that prolonged and severe alcohol abuse in men is compatible with normal sexual function during sobriety in the absence of substantial hepatic or gonadal failure.
Massive Rectal Bleeding from a Dieulafoy Lesion in the Rectum: Successful Endoscopic Clipping
Authors: S. Nomura, M. Kawahara, K. Yamasaki, Y. Nakanishi, M. Kaminishi
Journal: Endoscopy (2002)

The classic Dieulafoy lesion is a minute gastric mucosal defect which bleeds massively from an exposed artery. Although, only five cases of rectal Dieulafoy lesions have been reported, the methods of controlling the bleeding have differed from case to case [1] [2] [3] [4] [5]. We report a case of rectal Dieulafoy lesion in which the bleeding was controlled by endoscopic clipping.
Long QT Syndrome and Potentially Pathogenic Genetic Variants—In Reply
Authors: Sara L. Van Driest, Quinn S. Wells, Dan M. Roden
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Response of psychotic and nonpsychotic depression to phenelzine
Authors: P G Janicak, G N Pandey, J M Davis, R Boshes, D Bresnahan, R Sharma
Journal: American Journal of Psychiatry (1988)

The authors studied 52 depressed inpatients to examine treatment response to phenelzine, a monoamine oxidase (MAO) inhibitor. All patients were classified into one of three RDC categories (definitely psychotic, probably psychotic, and nonpsychotic). For the entire sample, the mean platelet MAO inhibition level achieved with phenelzine was greater than 80%. Response to treatment was determined by independent clinical assessment and by the change in rating scores from baseline; 68% of the nonpsychotic, 43% of the probably psychotic, and 21% of the definitely psychotic patients were classified as responders. This differential response rate is similar to that reported in the literature for tricyclic antidepressants.
Enzyme Changes Induced in Normal and Malignant Tissues with Chemical Agents. II. Effect of Various Compounds on the Cytochrome Oxidase Activity of Transplanted Tumors&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;3&lt;/xref&gt;
Authors: J LEITER, A D PARADIS, V S WARAVDEKAR
Journal: JNCI Journal of the National Cancer Institute (1953)

Enzyme Changes Induced in Normal and Malignant Tissues with Chemical Agents. II. Effect of Various Compounds on the Cytochrome Oxidase Activity of Transplanted Tumors Get access J. Leiter, J. Leiter Laboratory of Chemical Pharmacology, National Cancer Institute,5Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. D. Paradis, A. D. Paradis Laboratory of Chemical Pharmacology, National Cancer Institute,5Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar V. S. Waravdekar V. S. Waravdekar Laboratory of Chemical Pharmacology, National Cancer Institute,5Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 1, August 1953, Pages 177–188, https://doi.org/10.1093/jnci/14.1.177 Published: 01 August 1953 Article history Received: 22 April 1953 Published: 01 August 1953
Metabolism of Mammary-Gland Slices From Rats Receiving Progesterone and 3-Methylcholanthrene&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: E. Douglas Rees
Journal: JNCI Journal of the National Cancer Institute (1960)

Administration of 3-methylcholanthrene orally for as long as 62 days to young female albino rats receiving progesterone had no demonstrable effect, even in the presence of induced cancers elsewhere in the breast, on the values for the following metabolic parameters of mammary-gland slices: respiration, aerobic glycolysis, anaerobic glycolysis, and catalase activity, as compared to values obtained from control animals receiving either no treatment or sesame oil alone. Progesterone by itself, however, induced proliferation of mammary epithelium and the accompanying increase in QO2 was due to this proliferation, but after a peak was reached, the epithelium and respiration decreased to the level of controls. When 3-methylcholanthrene was administered with progesterone, the QO2 did not increase because the epithelium failed to proliferate. Liver slices from animals treated with progesterone alone had an increased and labile QO2, an effect which was not observed in slices from animals receiving 3-methylcholanthrene in addition to progesterone. Livers from animals receiving 3-methylcholanthrene had an increased lipide content. Treatment of the host did not influence the respiration of kidney slices. Preputial-gland slices showed an extreme variation in QO2 unrelated to treatment. The earliest, and smallest, cancer nodules permitting study had the characteristic neoplastic type of metabolism.
EPN-12PEDIATRIC SUPRATENTORIAL EPENDYMOMA: COMPARISON BETWEEN IMMUNOHISTOCHEMISTRY, FISH AND DNA METHYLATION ANALYSIS FOR RELA REARRANGEMENT AND HISTOLOGICAL CORRELATION
Authors: Melanie Pagès, Kristian Pajtler, David Castel, Stephanie Puget, Christian Sainte-Rose, Emmanuele Lechapt-Zalcman, Marcel Kool, David Capper, Fabrice Chrétien, Stefan Pfister, Jacques Grill, Pascale Varlet, Felipe Andreiuolo
Journal: Neuro-Oncology (2016)
THE CONTAGIOUSNESS OF TUBERCULOSIS.
Authors: H C Hallo
Journal: JAMA (1889)

Not least among the advances of the century is the establishment of the fact that phthisis may be transmitted. The labors ofListertaught the value of cleanliness even to those surgeons who do not accept all of his conclusions, and the investigations ofKochhave done a like service to the general practitioner. There are many who are yet unable to decide whether the bacillus tuberculosis is the cause or the result of phthisis; indeed, the feeble response that is made to the most approved methods of administration of the most available germicides, suggests very forcibly the thought that other factors may be equally necessary to the causation of consumption, and that the bacillus is not alone all powerful for evil. However this may be, one thing seems to have been clearly demonstrated regarding the etiology of phthisis, and that is, that the disease is transmissible; that it can
Soundings: Diagnosing house officer fatigue
Authors: George Dunea
Journal: BMJ (2003)

In a reaction  much hyped extrapolations about excessive hospital accidents and deaths, the educators and administrators who (over)regulate clinical medicine have decided that the root of all trouble is resident fatigue.

They might have been better off addressing the real structural defects of modern hospitals—too much paperwork and bureaucracy, unavailable patient records, nurses pushing paper instead of nursing, doctors' patients scattered over 12 floors, and chief residents (registrars) doing everything else but closely supervising junior house officers.

But instead the armchair generals have promulgated specific directions on how many hours residents may work, how many days they must take off for rest and recuperation, and how after a night on call they may spend the afternoon in bed, even if 80 patients are scheduled for the clinic that day.

The result is massive discontinuity and pervasive chaos. Senior attending physicians wander about alone because their residents are in class, in a (largely misnamed) continuity clinic, or in bed. Residents work in shifts, in teams, like primitive man hunting in packs, constantly signing out  one another, giving rise  the he is not my patient syndrome, so that no resident can name a patient truly his own.

Yet the armchair generals remain troubled. If fatigue is the cause of all evils, then how is it  be diagnosed? Don't we need criteria, algorithms? Fortunately a committee of academic medical school rear admirals has recently issued specific guidelines, explaining how a psychiatrist has assembled a list of symptoms suggestive of excessive fatigue. They include involuntary nodding off, waves of sleepiness, lethargy, irritability, mood lability, poor coordination, difficulty with short term memory, and tardiness or absences at work. Fatigue may manifest itself as depression and the resident may need to consult his/her primary care physician.

Clearly these vague instructions require quantification, peer review, and evidence based verification. But pending the development of a reliable downloadable algorithm, the committee advises that the psychiatrist expert in diagnosing fatigue may be contacted by email.
Blood Pentolysis in Rats Bearing Induced Sarcomata
Authors: Stephen N. Steen
Journal: JNCI Journal of the National Cancer Institute (1950)

Blood Pentolysis in Rats Bearing Induced Sarcomata Stephen N. Steen Stephen N. Steen Faculté de Médecine, Université de Genève, Switzerland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 1, August 1950, Pages 61–71, https://doi.org/10.1093/jnci/11.1.61 Published: 01 August 1950 Article history Received: 28 March 1950 Published: 01 August 1950
miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia
Authors: Silvia Nucera, Alice Giustacchini, Francesco Boccalatte, Andrea Calabria, Cristiana Fanciullo, Tiziana Plati, Anna Ranghetti, Jose Garcia-Manteiga, Davide Cittaro, Fabrizio Benedicenti, Eric R. Lechman, John E. Dick, Maurilio Ponzoni, Fabio Ciceri, Eugenio Montini, Bernhard Gentner, Luigi Naldini
Journal: Cancer Cell (2016)
Building capacity in field epidemiology: lessons learned from the experience in Europe
Authors: H T Walke, P M Simone
Journal: Eurosurveillance (2009)

Preview this article: Building capacity in field epidemiology: lessons learned from the experience in Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/14/43/art19376-en-1.gif
Phase I study of gene-mediated cytotoxic immunotherapy with AdV-tk as adjuvant to surgery and radiation for pediatric malignant glioma and recurrent ependymoma
Authors: Mark W Kieran, Liliana Goumnerova, Peter Manley, Susan N Chi, Karen J Marcus, Andrea G Manzanera, Maria Lucia Silva Polanco, Brian W Guzik, Estuardo Aguilar-Cordova, C Marcela Diaz-Montero, Arthur J DiPatri, Tadanori Tomita, Rishi Lulla, Lianne Greenspan, Laura K Aguilar, Stewart Goldman
Journal: Neuro-Oncology (2019)

Gene-mediated cytotoxic immunotherapy (GMCI) is a tumor-specific immune stimulatory strategy implemented through local delivery of aglatimagene besadenovec (AdV-tk) followed by anti-herpetic prodrug. GMCI induces T-cell dependent tumor immunity and synergizes with radiotherapy. Clinical trials in adult malignant gliomas demonstrated safety and potential efficacy. This is the first trial of GMCI in pediatric brain tumors. This phase I dose escalation study was conducted to evaluate GMCI in patients 3 years of age or older with malignant glioma or recurrent ependymoma. AdV-tk at doses of 1 × 1011 and 3 × 1011 vector particles (vp) was injected into the tumor bed at the time of surgery followed by 14 days of valacyclovir. Radiation started within 8 days of surgery, and if indicated, chemotherapy began after completion of valacyclovir. Eight patients (6 glioblastoma, 1 anaplastic astrocytoma, 1 recurrent ependymoma) were enrolled and completed therapy: 3 on dose level 1 and 5 on dose level 2. Median age was 12.5 years (range 7–17) and Lansky/Karnofsky performance scores were 60–100. Five patients had multifocal/extensive tumors that could not be resected completely and 3 had gross total resection. There were no dose-limiting toxicities. The most common possibly GMCI-related adverse events included Common Terminology Criteria for Adverse Events grade 1–2 fever, fatigue, and nausea/vomiting. Three patients, in dose level 2, lived more than 24 months, with 2 alive without progression 37.3 and 47.7 months after AdV-tk injection. GMCI can be safely combined with radiation therapy with or without temozolomide in pediatric patients with brain tumors and the present results strongly support further investigation. ClinicalTrials.gov NCT00634231
CIRCULATING "CANCER CELLS"
Authors: W R MCCUNE, E P GALLEHER, C WOOD
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TB-11MOLECULAR NEUROPATHOLOGY 2.0 - INCREASING DIAGNOSTIC ACCURACY IN PEDIATRIC NEUROONCOLOGY
Authors: Dominik Sturm, David T.W. Jones, Felix Sahm, David Capper, Andreas von Deimling, Monika Warmuth-Metz, Torsten Pietsch, Stefan M. Pfister
Journal: Neuro-Oncology (2016)
A double-blind study of bupropion and placebo in depression
Authors: J P Feighner, C H Meredith, W C Stern, G Hendrickson, L L Miller
Journal: American Journal of Psychiatry (1984)

Bupropion HCl, a new nontricyclic antidepressant, produced marked improvement in 49 hospitalized patients with primary depression at doses of 300-600 mg/day. Bupropion resulted in statistically significant differences from placebo as early as day 5, and by the end of the 4-week study 79% (N = 27) of the bupropion patients and 13% (N = 2) of the placebo patients showed much to very much improvement. Bupropion and placebo had similar side effect profiles. Tremor and sweating were reported more often with bupropion and headache, nausea, and tiredness with placebo.
Patient Input Blossoms From Seeds of SPORE Grants
Authors: L. Fintor
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Patient Input Blossoms From Seeds of SPORE Grants Get access Lou Fintor Lou Fintor Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 9, 4 May 1994, Pages 658–660, https://doi.org/10.1093/jnci/86.9.658 Published: 04 May 1994
Case 29-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Jules L. Dienstag, James J. Galdabini
Journal: New England Journal of Medicine (1980)

Presentation of Case First admission. A 62-year-old man was admitted to the hospital because of pain in the chest.He was well until four years earlier, when exertional angina pectoris developed, and hypertension was found. During the two years before admission he was dyspneic on exertion; angina occurred daily and increased in severity. Isosorbide dinitrate, propranolol, and hydrochlorothiazide were prescribed, with uncertain relief. On the day of entry chest pain recurred and persisted for several hours.The patient had smoked three packages of cigarettes daily in the past and drank eight cans of beer per day, with occasional drinks . . .
QOS-48PREVALENCE AND RISK FACTORS OF EARLY ENDOCRINE DISORDERS IN CHILDHOOD BRAIN TUMOR SURVIVORS: A NATIONWIDE MULTICENTER STUDY
Authors: Sarah Clement, Antoinette Schouten-van Meeteren, Annemieke Boot, Hedy Claahsen-vd Grinten, Bernd Granzen, Sen Han, Geert Janssens, Erna Michiels, Paul Van Trotsenburg, Peter Vandertop, Dannis Van Vuurden, Leontien Kremer, Huib Caron, Hanneke Van Santen
Journal: Neuro-Oncology (2016)

PURPOSE: To evaluate the prevalence of, and risk factors for early endocrine disorders in childhood brain tumor survivors (CBTS).PATIENTS AND METHODS: This nationwide study cohort consisted of 718 CBTS diagnosed between 2002 and 2012, surviving . 2 years after diagnosis.Exlusion of patients with craniopharyngeoma or a pituitary gland tumor.Results of endocrine investigations, performed at diagnosis and during follow-up, were collected from patient charts.Multivariable logistic regression was used to study associations between demographic, and tumor-and treatment-related variables, and the prevalence of early endocrine disorders.RESULTS: After a median follow-up of 6.6 years, 178 CBTS (24.8%) were diagnosed with an endocrine disorder.A total of 159 CBTS (22.1%) presented with at least one endocrine disorder within the first 5 years after diagnosis.Most common endocrine disorders were: growth hormone deficiency (12.5%), thyroid stimulating hormone deficiency (9.2%), precocious puberty (6.7%) and thyroidal hypothyroidism (5.8%).The risk of hypothalamic-pituitary dysfunction (N ¼ 138) was associated with radiotherapy (RT) )), younger age at diagnosis (OR 1.09 (95% CI: 1.04-1.14)),advanced follow-up time (OR 1.10 (95% CI: 1.02-1.18)),hydrocephalus at diagnosis (OR 1.77 (95% CI: 1.09-2.88)),suprasellar )) and infratentorial tumor site .CONCLUSION: The prevalence of early endocrine disorders among CBTS is high.The observation that 22.1% of the CBTS developed at least one endocrine disorder within 5 years after diagnosis stresses the importance of early and regularly assessment of endocrine function in CBTS at risk for endocrine damage.Overall survival
State Initiatives to Control Medication Costs — Can Transparency Legislation Help?
Authors: Ameet Sarpatwari, Jerry Avorn, Aaron S Kesselheim
Journal: New England Journal of Medicine (2016)

Interview with Dr. Ameet Sarpatwari on state bills that aim to reduce drug spending by requiring companies to disclose R&D costs. (09:55)Download To evaluate the argument that high drug prices are a fair and necessary reflection of the high costs incurred to bring a product to market, 10 states have introduced bills that would require pharmaceutical firms to disclose those research and development costs.
<i>In Vivo</i> Visualization of Tumor Antigen-containing Microparticles Generated in Fluorescent-protein-elicited Immunity
Authors: Fei Yang, Shun Liu, Xiuli Liu, Lei Liu, Meijie Luo, Shuhong Qi, Guoqiang Xu, Sha Qiao, Xiaohua Lv, Xiangning Li, Ling Fu, Qingming Luo, Zhihong Zhang
Journal: Theranostics (2016)

In vivo optical spatio-temporal imaging of the tumor microenvironment is useful to explain how tumor immunotherapies work.However, the lack of fluorescent antigens with strong immunogenicity makes it difficult to study the dynamics of how tumors are eliminated by any given immune response.Here, we develop an effective fluorescent model antigen based on the tetrameric far-red fluorescent protein KatushkaS158A (tfRFP), which elicits both humoral and cellular immunity.We use this fluorescent antigen to visualize the dynamic behavior of immunocytes as they attack and selectively eliminate tfRFP-expressing tumors in vivo; swarms of immunocytes rush toward tumors with high motility, clusters of immunocytes form quickly, and numerous antigen-antibody complexes in the form of tfRFP + microparticles are generated in the tumor areas and ingested by macrophages in the tumor microenvironment.Therefore, tfRFP, as both a model antigen and fluorescent reporter, is a useful tool to visualize specific immune responses in vivo.
Effects of 6-Azauracil on Galactose Metabolism in Mice, Dogs, and Man&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Levy, Allan H., Fritz, Richard D., Anderson, Elizabeth P., Landau, Bernard R.
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Effects of 6-Azauracil on Galactose Metabolism in Mice, Dogs, and Man Get access Allan H. Levy, Allan H. Levy National Cancer Institute,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard D. Fritz, Richard D. Fritz National Cancer Institute,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Elizabeth P. Anderson, Elizabeth P. Anderson National Cancer Institute,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Bernard R. Landau Bernard R. Landau National Cancer Institute,6Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 1, January 1958, Pages 53–61, https://doi.org/10.1093/jnci/20.1.53 Published: 01 January 1958 Article history Received: 25 June 1957 Published: 01 January 1958