tbuckley/cabot-search huggingface dataset:
Induction of nm23 Gene Expression in Human Colonic Neoplasms and Equal Expressions in Colon Tumors of High and Low Metastatic Potential
Authors: M. Haut, P. S. Steeg, J. K. V. Willson, S. D. Markowitz
Journal: JNCI Journal of the National Cancer Institute (1991)

Levels of expression of the murine nm23 gene inversely correlate with metastatic potential in several rodent tumor model systems. Expression of the human nm23 homologue also is lower in human breast cancers of high metastatic potential than in breast cancers of low metastatic potential. In the present study, we examined changes in nm23 expression during colon carcinogenesis as found in 18 matched pairs of normal and neoplastic human colon tissues. We found that a 0.8-kilo-base nm23 transcript was expressed in all samples of morphologically normal colon mucosa. In 16 of 18 colon neoplasms, nm23 expression was further increased in the neoplastic, compared with the morphologically normal, colonmucosa from the same individual. Expression of nm23 was elevated over normal mucosa in 3 of 3 polyps, in 2 of 3 nonmetastatic cancers, and in 11 of the 12 cancers that were metastatic at the initial presentation. The levels of nm23 expressed were similar in the 12 metastatic colon neoplasms and in the 6 colon neoplasms of lower clinical stage. In addition, nm23 expression was maintained in culture in each of 12 cell lines initiated from human colon neoplasms and did not differ between lines established from neoplasms of high or low metastatic capability. We concluded that nm23 was expressed in normal colon mucosa. Expression of nm23 increased during early stages of colon carcinogenesis and remained increased in metastatic colon cancer. Therefore, in the colon, tissue-specific events dissociate nm23 expression from loss of tumor metastatic competence. [J Natl Cancer Inst 83:712–716, 1991]
Abstract 3217: Regulation of senescence-associated p-Erk1/2 (SA-p-Erk1/2) by PEA-15 and PKC-α in human diploid fibroblasts
Authors: Yun Yeong Lee, Hong Seok Kim, Yong won Choi, In-Kyoung Lim
Journal: Cancer Research (2010)

Abstract Cellular senescence plays a key role in complicated biological processes, including development, aging, and tumorigenesis. Hallmarks of cellular senescence are metabolically active but not responsive to mitogens, therefore, decreased cell growth, cell cycle arrest, and reached to the flat and large cell shapes. We have recently reported that high expression of senescence-associated p-extracellular signal-regulated protein kinase 1/2 (SA-pErk1/2) can induce p21WAF1 expression via the activation of a transcription factor, SP1. In the present work, we investigated a biochemical regulation of the cytoplasmic sequestration of SA-pErk1/2 and found that PEA-15 (phosphoprotein enriched in astrocytes-15) could regulate translocation of SA-pErk1/2 to nuclei along with activation of PKC-α in senescent cells. It was proved by treatment of senescent cells with 12-O-tetradecanoylphorbol-13-acetate (TPA), which phosphorylated PEA-15 upon Ser104 residue via activation of PKC-α, which lead to release of SA-pErk1/2 form PEA-15 and then accompanied with nuclear translocation of SA-pErk1/2 along with PKC-α. Here, we, report the mechanism of cytoplasmic sequestration of SA-pErk1/2 and the relationship between PEA-15 and PKC-α in senescent human diploid fibroblasts (HDFs). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3217.
Abstract 2551: New understanding of cancer induction by ionizing radiation
Authors: Fredric J. Burns, Moon-Shong (Eric) Tang, Feng Wu
Journal: Cancer Research (2012)

Abstract Ionizing radiation is a unique carcinogen that provides an opportunity to vary the location of biological damage within a cell nucleus. For example, electron and x-ray beams deposit dose uniformly and randomly, while energetic heavy ions deposit dose in densely packed straight lines along the ion paths. Cancer yields for these 2 radiations vary as follows: upward curvature with dose rate sparing for random and linearity and no dose rate sparing for heavy ions. Dose rate sparing has long been assumed to be based on biological repair, but it has never been explained why dose responses should differ between these radiation or why repair should be ineffective for heavy ions. To understand this better, consider how the distribution of a typical molecular lesion, DNA double strand breaks (DSBs), varies with the type of radiation. For heavy ions at a specific energy, DSBs are expected to be lined up at random intervals along each track, their number being proportional to average track length in each nucleus, i.e. DSBs per nucleus are proportional to radiation dose (D). Increased charge on the heavy ion causes increased lineal energy transfer (L), i.e. DSBs are also proportional to L. Similarly for heavy ions fusions between DSBs would also be proportional to D and L. The comparable scenario for randomly deposited radiation differs in that the DSBs are distributed randomly with the nuclei. Their number remains proportional to radiation dose, but now fusions would exhibit proportionality to dose-squared as a direct result of the randomness of the DSBs. Moreover randomness eliminates simultaneity. Consequently DSBs can be eliminated before second ones occur close enough to fuse, which automatically gives rise to dose rate sparing. DSB fusion yields based on the above considerations would have the form Yfusions = CfLD + BfD2 with no dose rate sparing for the first term and positive dose rate sparing for the second term. If fusions are the initial lesion of radiation carcinogenesis, then Ycancer = CcaLD + BcaD2. Extensive cancer data in rat skin based on radiations with very different L values (56Fe (L = 150 keV/µ), 40Ar (L = 125 keV/ µ), 29Ne (L = 26 keV/ µ), 1H (L = 0.34 keV/ µ).) and doses are presented that confirm the existence of independent linear and dose-squared terms and that dose rate sparing only applies to the dose-squared term. The data support the proposition that DSB fusions could be the initial lesion of radiation carcinogenesis in the rat skin model. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2551. doi:1538-7445.AM2012-2551
Acute Trauma–Induced Fracture of the C7 Spinous Process Shown by Bone Scintigraphy
Authors: MONICA A. ROSSLEIGH, CLAYTON J. FRATER
Journal: Clinical Nuclear Medicine (2000)

After a weekend of strenuous and intense kick-boarding and swimming in the surf, a 16-year-old boy consulted a local sports medicine physician for acute lower neck pain. Bone scintigraphy confirmed a stress fracture of the spinous process of C7.
IMPROVEMENT IN QUALITY OF LIFE IN PATIENTS WITH DEGENERATIVE MITRAL REGURGITATION ST PROHIBITIVE SURGICAL RISK FOLLOWING TRANSCATHETER MITRAL VALVE REPAIR WITH THE MITRACLIP SYSTEM
Authors: Brijeshwar Singh Maini, O’Hara Haley, Aneesha Maini, Mubashir Mumtaz, Gregg Stone
Journal: Journal of the American College of Cardiology (2015)
Socio-economic deprivation independently predicts early recurrence in estrogen receptor positive breast cancer.
Authors: J Mansell, IJ Monypenny, AI Skene, P Abram, R Carpenter, JM Gattuso, CR Wilson, WJ Angerson, JC Doughty
Journal: Cancer Research (2009)

Abstract Abstract #6081 Introduction: Socio-economic deprivation is associated with reduced survival in breast cancer, but little is known about how it affects the pattern of disease recurrence. We investigated the relationships between deprivation, other risk factors and recurrence in post-menopausal women with operable ER+ breast cancer.&amp;#x2028; Methods: Patients who underwent potentially curative surgery for ER+ breast cancer between 1995 and 2005 at four UK centres were studied. Those patients whose area of residence was ranked in the highest quintile group according to the appropriate national Index of Multiple Deprivation were classed as deprived. The cumulative risk of recurrence was calculated using the Kaplan-Meier method, and hazard ratios were calculated using conventional and time-dependent Cox regression analysis stratified by centre.&amp;#x2028; Results: 4110 patients were available for analysis, of whom 821 (20.0%) were classed as deprived. The median age at diagnosis was 62 years in both deprived and non-deprived groups. Tumour size and grade did not vary with deprivation status, but nodal involvement (38.0% vs 34.3%, p=0.05, Fisher's exact test) and lymphovascular invasion (28.1% vs 23.6%, p=0.01) were more prevalent in deprived patients. The latter were also more likely to undergo mastectomy (53.3% vs 47.2%, p=0.002) and less likely to receive adjuvant radiotherapy (50.4% vs 58.5%, P&amp;lt;0.001) or chemotherapy (19.1% vs 22.8%, p=0.03).&amp;#x2028; Median follow up was 5 years from diagnosis. Raw cumulative recurrence at 2.5 years was 8.4% (95% confidence interval 6.4-10.4) in deprived and 6.1% (5.3-6.9) in non-deprived patients. At 5 years the corresponding rates were 15.8% (13.1-18.5) and 13.3% (11.9-14.7). Only distant recurrence contributed to this difference, the local and contralateral recurrence rates being almost identical in deprived and non-deprived groups. Time-dependent Cox regression analysis showed that deprivation was a significantly stronger predictor of recurrence within 2.5 years of diagnosis than at later intervals, with or without adjustment for other prognostic variables (p&amp;lt;0.05). For recurrence within 2.5 years, the unadjusted hazard ratio for deprivation was 1.64 (95% CI 1.22-2.22, p=0.001). After adjustment for age, mode of presentation, pathological variables and treatment, the hazard ratio was 1.51 (1.07-2.14, p=0.02).&amp;#x2028; Conclusions: Post-menopausal women with ER+ breast cancer who are resident in areas of high deprivation are at increased risk of early recurrence, independently of known differences in tumour pathology and treatment. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6081.
A SPECIFIC ANTIDOTE FOR TICAGRELOR
Authors: Sven Nylander, Susanne Pehrsson, Tord Inghardt, Thomas Antonsson, Peder Svensson, Tove Sjögren, Linda Öster, Annika Janefeldt, Ann-Sofie Sandinge, Phil Newton, Feenagh Keyes, Mark Austin, Andrew Buchanan
Journal: Journal of the American College of Cardiology (2015)
Stat Bite : Cost Per Life Year Gained for Selected Therapies
Authors: Jane Weeks
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Stat Bite : Cost Per Life Year Gained for Selected Therapies Get access Jane Weeks Jane Weeks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Page 1141, https://doi.org/10.1093/jnci/84.15.1141 Published: 05 August 1992
AB0648 Septic arthritis of the pubic symphysis: a report of 4 cases
Authors: H. Sahli, L. Dridi, R. Tekaya, I. Cherif, O. Saidane, I. Mahmoud, L. Abdelmoula, L. Chaabouni, R. Zouari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Septic arthritis of the pubic symphysis is rare and causes many difficulties to get the diagnosis. The risk factors are in most cases pelvic surgery, sports or drug addiction. Its management is not well codified. We report four cases. <h3>Results</h3> : There were 2 men and 2 women. The mean age of the patients was 56 years (range 35 to 76 years). A predisposing condition was noted in 2 cases: pelvic surgery. Patients presented with hypogastric pain (3 cases) and pain in the gluteal region irradiating to the genitor-urinary organs miming sciatalgia. The fever was present in all cases. The symptoms evolved at mean since 2 months. The physical exam revealed a pain limitation of the hip and a pubic pain (4 cases). Inflammatory tests were rised in all cases. Pelvic radiography showed an irregular cortical with erosion of pubic symphysis and ischio-pubic branchs and enlarging of borders in all cases. Pelvic tomodensitometry was performed in all cases and confirmed these results in three cases and showed the presence of three collections around the pubic symphysis in one case. The bacteriological exams of these collections showed the presence of staphylococcus aureus. The anatomopathological exam, done in the other 3 cases, showed histopathologic signs of pyogenic infection in 2 cases and it was inconclusive in one case. Cytobacteriologic exam of urine revealed a Klebsiella pneumonia in one case. All the patients were treated by association of two antibiotics for 2 weeks, followed by one antibiotic for a total of 6 weeks. Evolution was excellent with resolution of pain, normalization of biologic inflammation and slow radiologic reconstructions, even for the patient with collections. Indeed, magnetic resonance imaging was perfomed a month after antibiotics beginning and has showed their clear regression. <h3>Conclusions</h3> Infectious symphysitis should be evocated even in the absence of predisposing factors in front of prolonged fever and pain in the pelvic region. Imaging allows positive diagnosis and guide biopsy. Prognosis seems good under appropriate treatment. <h3>Disclosure of Interest</h3> None Declared
PRÓTESIS DE APOSICIÓN LUMINAL: INDICACIONES Y RESULTADOS EN PATOLOGÍA BILIOPANCREÁTICA
Authors: I Peñas, G González, R Sánchez-Ocaña, F Santos Santamarta, V Busto Bea, A Loza Vargas, R Amo Alonso, P Gil-Simón, C De La Serna Higuera, M Pérez-Miranda
Journal: Endoscopy (2014)

Introducción: Los resultados preliminares con las PAL son prometedores, aunque sólo están aprobadas para colecciones pancreáticas.
Initial evaluation of a new plastic pancreatic duct stent for endoscopic ultrasonography-guided placement
Authors: Takao Itoi, Atsushi Sofuni, Takayoshi Tsuchiya, Kentaro Ishii, Nobuhito Ikeuchi, Reina Tanaka, Junko Umeda, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Takako Takayama, Fuminori Moriyasu
Journal: Endoscopy (2015)

There are currently no plastic pancreatic duct stents that have been designed for endoscopic ultrasonography (EUS)-guided placement. This study prospectively evaluated the feasibility and efficacy of a new, single-pigtail, plastic stent. Eight patients with main pancreatic duct stricture or stenotic pancreatojejunostomy underwent EUS-guided placement of the pancreatic duct stent. The stent was placed successfully in all cases (8/8). Treatment success was achieved in all cases (8/8). A mild adverse event associated with the procedure was observed in one patient but there were no other adverse events during a mean follow-up of 7.4 months. This new pancreatic duct stent appears to be feasible and effective for EUS-guided stenting.
HOSPITALIZATION FOR PULMONARY EMBOLISM ASSOCIATED WITH ANTECEDENT TESTOSTERONE OR ESTROGEN THERAPY IN PATIENTS FOUND TO HAVE FAMILIAL THROMBOPHILIA
Authors: Matan Rothschild, Ashwin Vijaykumar, Michael Goldenberg, Nasim Motayar, Jonathon Weber, Marloe Prince, Charles Glueck, Ping Wang
Journal: Journal of the American College of Cardiology (2016)
FRI0357 Certolizumab pegol is effective in children with JIA not responsive to other TNF alpha antagonists
Authors: N. Tzaribachev
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patients with polyarticular juvenile idiopathic arthritis (JIA) may not respond sufficiently to methotrexate (MTX) combined with TNF Alpha antagonists (TNFA). In this cases switching to another TNFA might be beneficial. In case of non-response to the second TNFA it is recommended to change the treatment principle to another biologic. Certolizumab pegol (CZP) consists in a Fab fragment of a pegolated monoclonal TNF Alpha antibody. CZP is the only pegolated (conjugated with polyethylenglycol) TNFA so far. Pegolation is meant to be one of the reasons for improved pharmacokinetic properties leading to site dedicated suppression of the inflammation. <h3>Objectives</h3> The aim of the retrospective study was to evaluate the efficacy and safety of CZP in children with polyarticular course JIA not responsive to other TNFA. <h3>Methods</h3> Based on a search of the hospital database patients with polyarticular course JIA treated with CZP and at least one other TNFA (prior to CZP) were identified. The active joint count was documented at week 0, week 6-12 and week 24-36. Efficacy was evaluated by the decrease of the number of active joints over time. For the safety analysis adverse events (AE) were documented. <h3>Results</h3> 22 patients (4 boys) were identified. The age range at initiation of CZP treatment was 9-17 years. 18 children were treated with 2 TNFA before CZP was introduced. 18 patients received concomitantly subcutaneous MTX. At week 0 all patients had active joints (median 14, min. 3, max. 36). At week 6-12 one patient did not respond. Out of the remaining 21 patients 0 active joints were found in 11; the active joint count has decreased in the remaining 9 (median 2, min. 0, max. 4). At week 24-36 the number of patients with active joints has further decreased to 6 (15 patients had 0 active joints). The remaining 6 patients had a median active joint count of 2 (min. 1, max. 4). In this cohort only one AE occurred – skin reaction to CZP, which disappeared spontaneously. <h3>Conclusions</h3> Despite the recommendation of switching the treatment principle after non-response to two TNFA in children with JIA, the results of this study point to the capacity of CZP to gain control over the disease in this short-term analysis and therefore CZP might become a treatment option in those cases (the drug is still off-label use). CZP treatment was overall well tolerated. <h3>Disclosure of Interest</h3> None Declared
380P Prospective randomized trial of standard antiemetic therapy with yoga versus standard antiemetic therapy alone for highly emetogenic chemotherapy induced nausea and vomiting in South Asian population
Authors: S.L. Jakhar, G. Singh, T. Kothari, S. Narayan, A. Kapoor, T. Syiem, R. Purohit, H.S. Kumar, N. Sharma, A. Solanki
Journal: Annals of Oncology (2015)
Transmural air leak following endoscopic submucosal dissection: a non-useful computed tomography finding
Authors: R. Coriat, S. Leblanc, E. Pommaret, A. Chryssostalis, F. Prat, S. Chaussade
Journal: Endoscopy (2010)

We read with great interest the recent article by Onogi et al. [1], which reported the “transmural air leak” incidence in patients undergoing endoscopic submucosal dissection (ESD) of a gastric lesion. Their conclusions are an important contribution to promote ESD as a treatment in gastric lesions. The authors showed, in a large consecutive series, an excellent low rate of endoscopically visible perforation during ESD (0.8 %) but a high transmural air leak rate (13 %). Air leak incidence was higher in cases where resection size was large, or the procedure duration had been prolonged.
Abstract 4425: Regulation of gamma-secretase in breast cancer cells
Authors: Yueming Li, Jennifer Chien
Journal: Cancer Research (2011)

Abstract Gamma-secretase inhibitors are being actively pursued in preclinical and clinical studies for treatment of breast and other cancers. However, little is known on the regulation gamma-secretase in breast cancer cells. A better understanding of gamma-secretase and its involvement in breast cancer will be critical for the development of target-based therapies. A thorough investigation on gamma-secretase related research has been hampered due to the complexity of this protease and technical challenges. Gamma-secretase is a macromolecular complex composed of at least four proteins: presenilin (PS), Nicastrin (Nct), Pen2 and Aph1. Remarkably, only a small fraction of the four protein complex is catalytically active and total amount of PS protein is not always correlated with gamma-secretase activity. Therefore, detection of the level of individual subunits doesn't necessary reflect the activity of gamma-secretase. In addition, detection of gamma-secretase activity requires either large quantities of cells for membrane preparation or transitionally and stably expression of the substrates. These assays limit the ability to quickly characterize γ-secretase activity in multiple cancer cell lines and primary cells. To overcome these barriers, we have developed a variety of the activity-based probes and assays that allow us to investigate the active gamma-secretase complex and real-time inhibition of gamma-secretase in any cellular system. We have characterized gamma-secretase in basal A and B as well as luminal type of breast cancer cell lines and their sensitivity toward structurally distinct gamma-secretase inhibitors. We have found that different types of breast cancer cells exhibit distinctive gamma-secretase activity. Inhibition of gamma-secretase activity suppressed the migration, invasion and metastasis of aggressive breast cancer cell lines. An in depth examination of the function and regulation of gamma-secretase in breast cancer cells could lead to the development of more effective treatments of breast cancer and other malignancies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4425. doi:10.1158/1538-7445.AM2011-4425