tbuckley/cabot-search huggingface dataset:
Case 45-1964
Authors: Allan I. Sandler, Walter G. J. Putschar
Journal: New England Journal of Medicine (1964)

Presentation of CaseA forty-one-year-old mechanical engineer was admitted to the hospital because of hepatosplenomegaly.For the past three years he had been bleeding intermittently from hemorrhoids. Nine days before admission he entered another hospital to undergo hemorrhoidectomy; physical examination revealed enlargement of the liver and spleen, and he was transferred to this hospital.Nineteen years before entry the patient spent six weeks in another hospital because of infectious hepatitis; jaundice did not recur thereafter. He had had a duodenal ulcer that bled eight years before admission and perforated one year and again two years later, when a partial gastrectomy . . .
PWE-268 A systematic review comparing laparoscopic versus open adhesiolysis in patients with adhesional small bowel obstruction
Authors: A Khawaja, MS Sajid, MK Baig
Journal: Gut (2015)

<h3>Introduction</h3> The objective of this article is to evaluate whether surgical outcomes differ between laparoscopic versus open approach for adhesiolysis in patients presenting with adhesional small bowel obstruction (ASBO). <h3>Method</h3> A systematic review of literature on published comparative studies reporting the surgical outcomes following laparoscopic versus open adhesiolysis for ASBO was undertaken using the principles of meta-analysis. <h3>Results</h3> Ten retrospective comparative studies on 37,038 patients evaluating the surgical outcomes in patients undergoing laparoscopic versus open adhesiolysis for ASBO were systematically analysed. There were 31778 patients in open group and 5260 patients in laparoscopic group. Laparoscopic adhesiolysis resulted in the reduced risk of post-operative complications [odds ratio, 0.36 (CI, 0.28–0.46), p &lt; 0.00001], post-operative mortality [odds ratio, 0.31 (CI, 0.23–0.42), p &lt; 0.00001] and surgical site infections [odds ratio, 0.22 (CI, 0.12–0.43), p &lt; 0.00001]. In addition, the risk of respiratory complications, cardiac complications, bowel resection, post-operative ileus, venous thromboembolism [odds ratio, 0.36 (CI, 0.24–0.53), p &lt; 0.00001] and infective complications [odds ratio, 0.41 (CI, 0.34–0.49), p &lt; 0.00001] was also lower in patients undergoing laparoscopic adhesiolysis. Length of hospital stay was statistically shorter in laparoscopic group. However, statistical equivalence was seen in variables of re-operation rate, duration of operation and risk of neurological complications. There was significant heterogeneity among included studies. <h3>Conclusion</h3> Laparoscopic adhesiolysis for ASBO seems to have clinically proven advantage over open approach in terms of several operative and post-operative outcomes measures in patients whom the procedure was considered feasible. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Wullstein C, Gross E. Laparoscopic compared with conventional treatment of acute adhesive small bowel obstruction. Br J Surg. 2003;90(9):1147–1151 Chopra R, McVay C, Phillips E, Khalili TM. Laparoscopic lysis of adhesions. Am Surg. 2003;69(11):966–968 Mancini GJ, Petroski GF, Lin WC, Sporn E, Miedema BW, Thaler K. Nationwide impact of laparoscopic lysis of adhesions in the management of intestinal obstruction in the US. J Am Coll Surg. 2008;207(4):520–526 Khaikin M, Schneidereit N, Cera S <i>et al</i>. Laparoscopic vs. open surgery for acute adhesive small-bowel obstruction: patients’ outcome and cost-effectiveness. Surg Endosc. 2007;21(5):742–746 Grafen FC, Neuhaus V, Schob O, Turina M. Management of acute small bowel obstruction from intestinal adhesions: indications for laparoscopic surgery in a community teaching hospital. Langenbeck’s Arch Surg. 2010;395(1):57–63
Risks of Postmenopausal Hormone Replacement
Authors: Henk R. Franke
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Is panitumumab monotherapy safe in metastatic colorectal cancer patients over 70 years old?
Authors: Jerome Martin-Babau, Jean-Yves Douillard, Olivier Jean Marie Dupuis, Marc Porneuf, Jean François Ramée, Jean-Luc Raoul, Philippe Deguiral, Roger Faroux, Alain Gourlaouen, Laurent Miglianico, Sylvie Van Hulst, C. El Hannani, James Bassoulet, Claire Stampfli, Christian Riche, Fanny Marhuenda, Delphine Deniel Lagadec, Veronique Jestin Le Tallec, Francoise Grude, Jean-Philippe Metges
Journal: Journal of Clinical Oncology (2015)

714 Background: Metastatic Colorectal Cancer (mCRC) often occurs in patients older than 70 years old. Monoclonal antibodies targeting EGFR have improved the outcome of mCRC patients. Panitumumab in monotherapy is indicated in wild-type K-RAS mCRC progressing disease following fluoropyrimidine-, oxaliplatin- and irinotecan-containing chemotherapy regimens. Very few data are available in elderly patients receiving panitumumab. Methods: Based on the cohort of the Observatory of Cancer B PL in France, we studied the efficacy and tolerance of panitumumab. We retrospectively collected data from patients treated between July 2008 and January 2014 and older than age 70 and compared the results between two cohorts: one contained patients ages 70 to 74; the other contained patients age 75 and older. Results: 136 patients were identified. The median age was 77. The median number of course received was 7 infusions. There was no difference in outcomes between the patients of the two cohorts. Median overall survival was 6.16 months. Median PFS was 13 weeks. The older patients received less previous chemotherapy ligns than the younger with a statistical difference (p=0.023). Tolerance was acceptable with a skin toxicity rate of 67% and 11.5% of grade 3-4. No diarrhea or hypomagnesemia were reported. Conclusions: Our study shows that panitumumab is feasible in elderly patients "in the real world" and has comparable efficacy than in younger patients.
Test for a Maternal Influence in the Development of Mammary Gland Tumors in Agent-Free Strain C3Hb Mice
Authors: W E HESTON, M K DERINGER
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Test for a Maternal Influence in the Development of Mammary Gland Tumors in Agent-Free Strain C3Hb Mice Get access W. E. Heston, W. E. Heston National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer Margaret K. Deringer National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 1, August 1952, Pages 167–175, https://doi.org/10.1093/jnci/13.1.167 Published: 01 August 1952 Article history Received: 22 April 1952 Published: 01 August 1952
Ischaemic preconditioning
Authors: D. YELLON
Journal: Cardiovascular Research (1993)

Journal Article Ischaemic preconditioning Get access DEREK YELLON DEREK YELLON Head of Division of Cardiology, University College London Medical School, UK Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 27, Issue 10, October 1993, Pages 1882–1883, https://doi.org/10.1093/cvr/27.10.1882 Published: 01 October 1993
Ghosts
Authors: Samuel T Ives
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Managing Marine Plastic Pollution: Policy Initiatives to Address Wayward Waste
Authors: John H. Tibbetts
Journal: Environmental Health Perspectives (2015)

A 91 A few times a year, volunteers fan out along the causeway that links the South Carolina mainland with the seashore community of Folly Beach to clean up plastic bottles, straws, bags, and other debris from along the road and the salt marsh.Some of this debris has come from cities miles away.On windy days, litter is often blown off city streets into waterways.During rainstorms, debris floats into drains that empty into rivers.Other trash probably came from places closer to home."I see bags and other plastic flying off the beds of pickup trucks going down the causeway," says Marty Morganello, who organizes the cleanups for the Charleston-area chapter of the nonprofit Surfrider Foundation."I see them coming out the open windows of cars and out the backs of garbage trucks and even recycling trucks.This material is lightweight, and if you don't secure it, it will fly away."Beach cleanups yield enormous amounts of trash, with plastic items a major constituent. 1Although the human health impacts of this marine plastic pollution remain poorly characterized, it is widely seen as an emerging problem that deserves much more research attention. 2Likewise, there is a growing urgency among industry, government, nongovernmental organizations, and environmental groups to develop tools and policies to track, capture, and recycle plastic waste before it reaches the ocean.
Parity and Hypertension.
Authors: J T Baird, L G Quinlivan
Journal: Annals of Internal Medicine (1973)

Among the many physiological factors which have been hypothesized as associated with elevated blood pressure levels and increased incidence of hypertension, the possible effect of pregnancy in the production of these conditions has proven to be among the more elusive to quantitate and evaluate. At the same time, the possible association is among the more interesting from an epidemiological standpoint, not only because of the importance of the primal question of whether or not pregnancy is a factor in the etiology of hypertension, but also because of the component parts represented by those pregnancies complicated by preeclampsia. Age is considered by many observers to be an important factor in the production of residual hypertension, and the statistical association of age with increased blood pressure levels is probably the most pronounced and easily demonstrated phenomenon observable in any study population. A moderate decline in average diastolic blood pressure among the general population after age 55 is an exception to this, and is less frequently evaluated. Body measurements, race, and several other variables may be cited as also being correlated with blood pressure levels, however, their effect is much less significant than that observable for age.
AB0536 Immunosuppressive Therapy is Promising for Pulmonary Arterial Hypertension Associated with Connective Tissue Disease (CTD-PAH)
Authors: Y. Takeshima, Y. Iwasaki, R. Kato, S. Sumitomo, H. Shirai, B. Natsumoto, M. Ota, S. Teruya, H. Tsuchiya, T. Komai, N. Hanata, H. Shoda, M. Shibuya, K. Fujio, H. Maki, M. Hatano, K. Yamamoto
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Association of CTD is one of the poor prognostic factors for PAH patients. Although it remains unclear whether immunosuppressive therapy is effective for CTD-PAH, the efficacy of immunosuppressive agents for CTD-PAH has been reported recently. PAH patients with systemic lupus erythematosus (SLE) or mixed connective tissue disease (MCTD), especially in early stage, are suggested to be good responders to immunosuppressive therapy [1]. <h3>Objectives</h3> To evaluate the efficacy of immunosuppressive therapy for CTD-PAH (except SSc-PAH) patients by close monitoring with right heart catheterization (RHC). <h3>Methods</h3> Here we report clinical courses of 6 CTD-PAH cases under management with immunosuppressive agents. In all cases, we started high-dose prednisolone (PSL) followed by intravenous cyclophosphamide (IVCY) without adding or modifying vasodilators and evaluated therapeutic efficacy on hemodynamics with RHC. Initial post-therapeutic RHC was performed within three months. Paired t-test was used for comparison of pre- and post-therapeutic hemodynamics: mean pulmonary arterial pressure (mPAP) and pulmonary vascular resistance (PVR). In one case, we analyzed her peripheral blood by Fluorescence Activated Cell Sorting (FACS) analysis before and after IVCY therapy. <h3>Results</h3> All cases were Japanese females and mean age was 41.3±12.2 years old; one with SLE, one with SLE plus CREST syndrome, one with MCTD and three with Sjögren syndrome. Each hemodynamic was significantly improved. Mean mPAP was 41.0±9.5 mmHg and 27.0±8.5 mmHg (<i>p</i>&lt;0.01), and mean PVR was 7.89±3.45 WU and 5.14±2.12 WU (<i>p</i> &lt;0.05) in pre- and initial post-therapeutic RHC respectively. After first follow-up RHC, vasodilator therapy was modified if necessary. In four cases, the second RHC was performed within half a year after the first evaluation. Although mPAP got slightly worse (31.8±5.9 mmHg), PVR maintained improvement (5.28±1.34 WU). The analysis of B-cell count showed reduction from 241 /μL to 129 /μL. <h3>Conclusions</h3> High-dose PSL and IVCY are effective to all cases, indicating the importance of the immune system in CTD-PAH etiology. RHC revealed that only high-dose PSL can remarkably reduce mPAP and PVR. The response to preceding PSL monotherapy could predict overall effectiveness of immunosuppressive therapy for CTD-PAH patients. In addition, B-cell reduction in PBMC was apparent after IVCY, suggesting that B-cell count may predict activity. <h3>References</h3> Jais X et al. Arthritis Rheum. 2008;58:521-31. <h3>Disclosure of Interest</h3> None declared
PTH-312 5 year results of radical resection and hipec for colorectal cancer peritoneal metastases
Authors: N Henderson, F Polignano
Journal: Gut (2015)

<h3>Introduction</h3> Peritoneal metastases complicate 10 to 30% of patients with colorectal cancer.<sup>1</sup>Peritoneal carcinomatosis is traditionally associated with palliative care and a life expectancy measured in months.<sup>2</sup>Modern multiagent systemic chemotherapy prolongs survival in such cases to 18 months but many patients (60%) fail to complete the course due to side effects. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are effective treatments for advanced colorectal cancer with peritoneal metastases allowing median survival of up to 62 months and 5 year survival in excess of 40%.<sup>3</sup>These modalities are being employed in Ninewells Hospital in Dundee, since 2009. <h3>Method</h3> Prospectively collected data from consecutive colorectal cancer patients with peritoneal metastases undergoing CRS and HIPEC. Patients were selected at multi-disciplinary meeting if expected peritoneal cancer index was less than 20 in abscence of significant comorbidities. Staging included CT chest abdomen and pelvis, PET scan and selected patients underwent a pre-operative staging laparoscopy to confirm disease extent. Following resection of all macroscopically visible disease the abdomen is closed and perfused with heated oxaliplatin and synchronous intravenous 5FU according to the Villejuif protocol. Patients are routinely admitted to ICU for at least 24 h. <h3>Results</h3> Since August2009,43 patients with colorectal cancer peritoneal metastases have been treated with a mean age of 55 years (20 to 78) and a median hospital stay of 24 days. 40% of patients experienced complications post operatively (23% Clavien-Dindo 3 and 4) 3 patients had a return to theatre (left colonic ischaemia, small bowel fistula, wound dehiscence). Most complicaitons were managed percutaneously with radiologically placed drains. There were no deaths. The median peritoneal cancer index was 19 (last 8 cases:12). Multi-visceral resections accounted for 68% of the cases, 53% had isolated peritoneal metastases whilst 47% had been treated for synchronous or metachronous liver metastatic disease. Completeness of cytoreduction (R0) was achieved in 98% (1 patient). Median survival at 12 months is 79%, 18 months 69%, 48% at 24 months and 37% at 60 months. <h3>Conclusion</h3> Radical resection and HIPEC for colorectal cancer peritoneal metastases are safe in selected patients and long term survival is possible even in the presence of liver metastatic disease. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Jayne DG. Br J Surg. 2002;89:1545–1550 Chu DZ. <i>Cancer</i>1989;<b>63</b>:364–367 Elias D. J Clin Oncol. 2009;27(5)
Beneficial Effect Of Anticoagulants In The Management Of Patients With Acute Promyelocytic Leukemia (APL): Results Of a Multicenter, Retrospective Epidemiologic Study Of The Disseminated Intravascular Coagulation Patients In Japan
Authors: Kazuo Kawasugi, Tadashi Yamamoto, Naoki Shirafuji, Takayuki Ikezoe, SungGi Chi, Yoshitaka Ogino, Naoki Takezako
Journal: Blood (2013)
AB1102 Comparative Analysis of Local Non-Infectious Complications of Surgical Wounds After Hip and Knee Arthroplasty in Patients with Rheumatoid Arthritis and Osteoarthritis
Authors: A. Khramov, M. Makarov, V. Amirdzhanova, S. Makarov, E. Byalik, V. Pavlov, G. Vardikova
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Surgical treatment of patients with rheumatoid arthritis (RA) associated with increased risk of complications. It is caused presence of an inflammatory process, osteoporosis, the reduced physical activity, the severity of functional impairment, long-term glucocorticoid therapy, biologic and disease-modifying antirheumatic drugs. All this contributes to increase the risk of perioperative complications, including non-infectious complications of surgical wounds. <h3>Objectives</h3> To conduct a comparative analysis of local non-infectious complications of surgical wounds (delayed wound healing, marginal necrosis, wound dehiscence) after total hip and knee arthroplasty in patients with RA and osteoarthritis (OA). <h3>Methods</h3> In the period from 1998 to 2013 in patients with RA and OA was performed 1605 operations of hip replacement surgery (RA - 385, OA - 482) and knee replacement surgery (RA - 527, OA - 211). <h3>Results</h3> There were 29 (1.81%) local non-infectious complications of wounds. After hip arthroplasty local non-infectious complications of wounds developed in 7 (0,44%) patients, all diagnosed with RA. Local non-infectious complications of the wound after knee arthroplasty was 22 complications, from them - 17 (1.06%) in patients with RA; 5 (0.31%) in patients with OA. Revealed a significantly greater number of local non-infectious complications of surgical wounds after hip and knee arthroplasty in patients with RA (p&lt;0,005). <h3>Conclusions</h3> The results confirm that the surgical treatment of patients with RA, requires a specific approach, which consists in a competent medication administered to the patient with rheumatologist and careful treatment of the bone and surrounding tissues during surgery. <h3>Disclosure of Interest</h3> None declared
A Combined Hemoglobin—Hemosiderin Stain
Authors: H PUCHTLER, F SWEAT
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Osmotic Myelinolysis
Authors: B L Hart, R P Eaton
Journal: New England Journal of Medicine (1995)

Figure 1. A 30-year-old alcoholic woman presented with confusion and disorientation after a grand mal seizure. The patient's serum sodium concentration on admission was 99 mmol per liter. Treatment was initiated with a slow infusion of normal saline, resulting in serum sodium values of 102 mmol per liter 4 hours after admission, 104 mmol per liter at 8 hours, 115 mmol per liter at 12 hours, 118 mmol per liter at 18 hours, and 125 mmol per liter at 24 hours. The patient initially had dysarthria, with slurred speech, and a slow finger-to-nose test on cerebellar examination, although there was . . .