tbuckley/cabot-search huggingface dataset:
Abstract 4098: Does Calcium Supplementation Increase Cardiovascular Risk: the Women's Health Initiative Randomized Trial
Authors: Judith Hsia, Gerardo Heiss, Hong Ren, Maurizio Trevisan, Philip Greenland, Karen Johnson, Matthew Allison, Marcia Stefanick, JoAnn Manson, Susan Heckbert, Nancy Dolan, Steve Sidney
Journal: Circulation (2006)

Background: Coronary and valvular calcification predict coronary heart disease (CHD) risk. Patients commonly ask if they should reduce their calcium consumption, but the literature on this topic is...
The European Union faces up to the threat of a pandemic: meeting at the DGV on the influenza A (H5N1) of the ad hoc group on communicable diseases Luxembourg 14 January 1998
Authors: J C Desenclos, R Manigat
Journal: Eurosurveillance (1998)

The transmission of an avian influenza H5N1 virus to a child in Hong Kong in May 1997 followed by the occurrence of 17 other human cases with a high case fatality rate (6/18, 33%) suggested that an influenza pandemic could be imminent and led many Europea
Substantial increase in listeriosis, Denmark 2009
Authors: A Kvistholm Jensen, S Ethelberg, B Smith, E Møller Nielsen, J Larsson, K Mølbak, J J Christensen, M Kemp
Journal: Eurosurveillance (2010)

In 2009, 97 cases of listeriosis were reported in Denmark (1.8 per 100,000), a significant rise over the previous year. The increase was seen both in cases of bacteraemia and meningitis and affected mainly people aged 70 years and older. A foodborne outbreak of eight cases was identified by pulsed-field gel electrophoresis typing. No explanation has so far been found for the marked increase in incidence. An increasing trend has been observed since 2003 and possible explanations are discussed.
Differential Inhibition by Fucoses of Aggregation of Rat Hepatoma Cells in Rotation-Mediated Cell Cultures2
Authors: Y. Kuroda
Journal: JNCI Journal of the National Cancer Institute (1974)

The effects of D-fucose and L-fucose on the aggregation of L-dimethylaminoazobenzene (DAB)-induced rat hepatoma cells dRLa-74 and dRLh-84, which have a low and high tumor-producing activity, respectively, were examined in rotation-mediated cell culture. D-Fucose had no effect on the aggregation of dRLa-74 cells at all concentrations, whereas it had concentration-dependent effects on the aggregation of dRLh-84 cells. At the 30 mM concentration, D-fucose was effective in inhibiting the aggregation of dRLh-84 cells to about one-third that of the control cultures in their mean diameter. L-Fucose had concentration-dependent inhibitory effects on the aggregation of both dRLa-74 and dRLh-84 cells, though its effects on dRLh-84 cells were stronger than on dRLa-74 cells. In the presence of 30 mM L-fucose, the mean diameter of aggregates of d RLh-84 cells was about onefourth that of the control cultures.
Abstract IA07: The application of integrative sequencing for precision oncology
Authors: Arul Chinnaiyan
Journal: Clinical Cancer Research (2016)

Abstract Studies of the genomic landscape of human cancers have demonstrated that most solid cancers have a multitude of mutations, a subset of which may be “actionable” with current drugs. Thus, the personalization of therapy for cancer will require molecular characterization of unique and shared genetic aberrations. Patients who have advanced/refractory cancer and are candidates for clinical trials could potentially benefit by identifying eligibility for “targeted” drugs based on the “actionable” genes in their specific tumor. Growing technological advances in genomic sequencing has now made it possible to consider the use of sequence data in a clinical setting. MI-ONCOSEQ initiative brings together expertise at the University of Michigan including clinical oncology, cancer genetics, bioinformatics, clinical pathology, social and behavioral sciences, and bioethics in order to implement clinical cancer sequencing. Our study identifies patients with advanced or refractory cancers that are eligible for clinical trials, consent them to the study, obtain biospecimens (tumor tissue, germline tissue) and store clinical data. The clinical sequencing team processes biospecimens, performs comprehensive sequencing and analysis of tumors to identify point mutations, copy number changes, rearrangements/gene fusions, and aberrant gene expression. Finally, a multi-disciplinary Precision Medicine Tumor Board deliberates on return of actionable or incidental genomic results. Citation Format: Arul Chinnaiyan. The application of integrative sequencing for precision oncology. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr IA07.
Abstract A12: miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively
Authors: Hua Tang
Journal: Cancer Research (2016)

Abstract miRNAs typically downregulate the expression of target genes by binding to their 3'UTR, and dysregulation of miRNAs may contribute to tumorigenesis. Here, we found that miR-346 and miR-138 competitively bind to a common region in the 3'UTR of hTERT mRNA and have opposite effects on the expression and function of hTERT in human cervical cancer cells. Furthermore, G-rich RNA sequence binding factor 1 (GRSF1) mediates the miR-346-dependent upregulation of hTERT by binding to the miR-346 middle sequence motif (CCGCAU) which forms a “bulge loop” when miR-346 is bound to the hTERT 3'UTR, facilitating the recruitment of hTERT mRNA to ribosomes to promote translation in an AGO2-independent manner. Conversely, miR-138 suppresses hTERT expression in an AGO2-dependent manner. Interestingly, replacement of the miR-138 middle sequence with that of miR-346 resulted in an upregulation of hTERT expression in a GRSF1-dependent manner. Moreover, miR-346 depends on GRSF1 to upregulate another target gene, activin A receptor, type IIB (ACVR2B), in which miR-346 “CCGCAU” motif is essential. These findings reveal novel mechanisms of miRNA-mediated upregulation of target gene expression and describe the coordinated action of multiple miRNAs to control the fate of a single target mRNA through binding to its 3'UTR. Citation Format: Hua Tang. miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr A12.
EFFECTS OF CHRONIC EXCESS SALT INGESTION
Authors: Lewis K. Dahl, Martha Heine, Lorraine Tassinari
Journal: The Journal of Experimental Medicine (1962)

Using the genetic technique of selective inbreeding, it has been possible to quickly develop two statistically separable populations from one unselected strain of Sprague-Dawley rats. One of these is very sensitive, the other very resistant, to the development of experimental hypertension from a high salt diet. It was suggested that similar genetic factors operate in man.
Ryanodine receptor-2: a necessity for gating store-operated Ca<sup>2+</sup>channels
Authors: Shanshan Song, Ramon J. Ayon, Jason X.-J. Yuan
Journal: Cardiovascular Research (2016)

This editorial refers to ‘Conformation of ryanodine receptor-2 gates store-operated calcium entry in rat pulmonary arterial myocytes’ by A.H.Y. Lin et al ., pp. 94–104. 

Store-operated Ca2+ entry (SOCE) is an important regulator of vascular tone as it is linked to a variety of functions including contraction, proliferation, and migration.1,2 It is well established that plasma membrane store-operated Ca2+ channel (SOCs) activation induces SOCE. Stimulation of surface receptors G protein and tyrosine kinase by extracellular agonists activates the phospholipase C (PLC)/phosphatidylinositol 4,5-bisphosphate (PIP2)/inositol 1,4,5-triphosphate (IP3) pathway that leads to IP3-mediated depletion of endoplasmic/sarcoplasmic reticulum (ER/SR) Ca2+ stores and subsequent activation of SOCs. Stromal interaction molecule (STIM1-2) and Orai (Orai1-3) proteins are identified as critical components in SOCs activation. Of these proteins, structure models for STIM1 and Orai have begun to illustrate the molecular mechanisms controlling activation of SOCs in many cell types including vascular smooth muscle cells (VSMCs).3–5 It has been shown that SOCE is driven by physical contact between STIM1 and Orai1 through the cytosolic CAD domain of STIM1, which binds directly to Orai1 inducing tetrameric channel formation in ER–PM junction.6

Members of the canonical transient receptor potential family (TRPC) have also been proposed to act as SOCs; in particular, TRPC1 is associated with SOCE in VSMCs.7,8 Similar to Orai1, STIM1 is also needed for TRPC1 channel formation in response to ER/SR Ca2+ store depletion. It has been suggested, however, that STIM1-dependent gating of TRPC1 is different from Orai1. Instead of binding directly, an electrostatic model proposed that gating is mediated by an intermolecular electrostatic …
Cost comparison of XELOX compared to FOLFOX4 with or without bevacizumab (bev) in metastatic colorectal cancer
Authors: L. Garrison, J. Cassidy, M. Saleh, F. Lee, R. Mena, J. Fuloria, V. Chang, T. Ervin, P. Stella, L. Saltz
Journal: Journal of Clinical Oncology (2007)

4074 Background: A recent randomized 2x2 phase III trial compared oral capecitabine + IV oxaliplatin (XELOX); IV 5FU/LV/oxaliplatin (FOLFOX4), XELOX+bev, and FOLFOX4+bev. FOLFOX4 was the regulatory control. XELOX was non-inferior to FOLFOX4 for progression-free survival, and bev-containing regimens were superior to comparison arms. This economic analysis compared expected costs in XELOX vs. FOLFOX4 arms in a US setting from a payer and societal perspective. Methods: Direct medical and indirect cost estimates (for patient time and travel) were compared. Resource use and patient time were estimated based on trial data and protocols. Data collected during the trial and used in the analysis were as follows: no. of visits / duration of drug administration, central venous access management, treatment of adverse events (AE), including hospital days for treatment-related AEs and total hours of ambulatory encounters. Unit costs were based on government fee schedules (i.e. Medicare reimbursements) and other published sources. Results: Total direct medical cost estimates were similar for bi-weekly FOLFOX4 and 3-weekly XELOX: $45,800 vs. $44,500. XELOX had higher drug costs while FOLFOX had higher drug administration costs, with about 15 more visits. Costs for hospitalization and ambulatory encounters were slightly lower for FOLFOX4; other medications and venous access were slightly higher for FOLFOX4. Similar patterns held for FOLFOX4+bev vs. XELOX+bev (total direct medical cost estimates $76,100 vs. $79,200). Indirect time cost estimates were lower with XELOX due to fewer cycles and visits: estimated savings range from $1000-$5000 depending on assumptions used. Conclusion: XELOX is estimated to have similar total direct medical costs and lower indirect costs compared with FOLFOX4. [Table: see text] No significant financial relationships to disclose.
Controllable synthesis of dual-MOFs nanostructures for pH-responsive artemisinin delivery, magnetic resonance and optical dual-model imaging-guided chemo/photothermal combinational cancer therapy
Authors: Dongdong Wang, Jiajia Zhou, Ruhui Chen, Ruohong Shi, Gaozheng Zhao, Guoliang Xia, Ren Li, Zhenbang Liu, Jie Tian, Huijuan Wang, Zhen Guo, Haibao Wang, Qianwang Chen
Journal: Biomaterials (2016)
Magnetic Resonance Imaging for Screening of Women at High Risk for Hereditary Breast Cancer
Authors: Kefah Mokbel, Abd Elrafea Elkak
Journal: Journal of Clinical Oncology (2001)

Article Tools SPECIAL DEPARTMENTS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2001.19.21.4184 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11689592 Magnetic Resonance Imaging for Screening of Women at High Risk for Hereditary Breast Cancer Kefah MokbelxKefah MokbelSearch for articles by this author , Abd Elrafea ElkakxAbd Elrafea ElkakSearch for articles by this author Show More The Breast Cancer Centre, St George’s Hospital and Medical School, London, United Kingdom https://doi.org/10.1200/JCO.2001.19.21.4184 First Page Full Text PDF Figures and Tables © 2001 by American Society of Clinical Oncology
IMPS-42CD70—A KEY DRIVER OF CHEMOKINE-MEDIATED IMMUNE SUPPRESSION AND INDICATOR OF NEGATIVE PROGNOSIS FOR GLIOBLASTOMA
Authors: Haitao Ge, Changlin Yang, Linchun Jin, Songsong Xia, Hongbo Bao, Yu Long, Luyan Mu, Yibo Yin, Jiping Qi, Yifan Chang, Jeffrey Drake, Gabriel De Leon, William A. Friedman, Duane A. Mitchell, Zhiguo Lin, Jianping Huang
Journal: Neuro-Oncology (2015)

Identifying factors that contribute to the aggressiveness of glioblastoma (GBM) is crucial for treating this deadly brain tumor. We demonstrate here that CD70, a member of the TNF family, is overexpressed by tumor cells in a subset of patients with low grade glioma and GBM. The elevated gene and protein expression is associated with increased tumor grade and recurrences. CD70 expression on primary GBM is correlated with T cells infiltration and tumor MHC class I expression which could potentially promote antitumor immunity based on our result that T cell infiltration is negatively associated with GBM proliferation. However, no correlation between T cell infiltration and prolonged survival is seen, suggesting that other factors may exist to suppress T cell function. Analysis from 155 primary GBM patients using RNA-seq data culled from TCGA indicates that the gene expression of CD70 is highly correlated with markers (CD4, CD25, CD163 and CD14) commonly expressed on immune suppressive cells such as Tregs and tumor associate macrophages. This result is in line with additional finding that CD70 positive tumors display a predominantly mesenchymal gene expression signature, a subtype of GBM that has greater infiltration by immune cells than other subtypes. In addition, tumors derived from patients with MGMT promoter un-methylation express high levels of CD70. Furthermore, our results suggest that CD70 is a key driver of chemokine mediated attraction for these immune suppressive cells infiltrating the tumor. Lastly, shorter overall survival was observed in these patients who have high CD70 expression compared to those with low CD70 expression on tumors. Taken together, the data suggest that CD70 plays a critical role in chemokine-mediated immune suppression and in GBM progression. Targeting GBM with a drug-conjugated CD70 antibody or CD70-CAR T-cells may improve the therapeutic efficacy for patients with GBM.
Multidrug Chemotherapy in the Treatment of Non-Elderly Patients with Hormone-Refractory Prostatic Carcinoma
Authors: A. Veronesi, G. Lo Re, S. Foladore, A. Merlo, N. Giuliotto, R. Talamini, S. Monfardini, None within the North-Eastern Italian Oncology Group (GOCCNE)
Journal: European Urology (1996)
Predictive Processing, Source Monitoring, and Psychosis
Authors: Juliet D. Griffin, Paul C. Fletcher
Journal: Annual Review of Clinical Psychology (2017)

A comprehensive understanding of psychosis requires models that link multiple levels of explanation: the neurobiological, the cognitive, the subjective, and the social. Until we can bridge several explanatory gaps, it is difficult to explain how neurobiological perturbations can manifest in bizarre beliefs or hallucinations, or how trauma or social adversity can perturb lower-level brain processes. We propose that the predictive processing framework has much to offer in this respect. We show how this framework may underpin and complement source monitoring theories of delusions and hallucinations and how, when considered in terms of a dynamic and hierarchical system, it may provide a compelling model of several key clinical features of psychosis. We see little conflict between source monitoring theories and predictive coding. The former act as a higher-level description of a set of capacities, and the latter aims to provide a deeper account of how these and other capacities may emerge.
Biomarker Panel for Chronic Graft-Versus-Host Disease
Authors: Jeffrey Yu, Barry E. Storer, Kushi Kushekhar, Mohammad Abu Zaid, Qing Zhang, Philip R. Gafken, Yuko Ogata, Paul J. Martin, Mary E. Flowers, John A. Hansen, Mukta Arora, Corey Cutler, Madan Jagasia, Joseph Pidala, Betty K. Hamilton, George L. Chen, Iskra Pusic, Stephanie J. Lee, Sophie Paczesny
Journal: Journal of Clinical Oncology (2016)

To identify diagnostic and prognostic markers of chronic graft-versus-host disease (cGVHD), the major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT).Using a quantitative proteomics approach, we compared pooled plasma samples obtained at matched time points after HCT (median, 103 days) from 35 patients with cGVHD and 18 without cGVHD (data are available via ProteomeXchange with identifier PXD002762). Of 105 proteins showing at least a 1.25-fold difference in expression, 22 were selected on the basis of involvement in relevant pathways and enzyme-linked immunosorbent assay availability. Chemokine (C-X-C motif) ligand 9 (CXCL9) and suppression of tumorigenicity 2 (ST2) also were measured on the basis of previously determined associations with GVHD. Concentrations of the four lead biomarkers were measured at or after diagnosis in plasma from two independent verification cohorts (n = 391) to determine their association with cGVHD. Their prognostic ability when measured at approximately day +100 after HCT was evaluated in plasma of a second verification cohort (n = 172).Of 24 proteins measured in the first verification cohort, nine proteins were associated with cGVHD, and only four (ST2, CXCL9, matrix metalloproteinase 3, and osteopontin) were necessary to compose a four-biomarker panel with an area under the receiver operating characteristic curve (AUC) of 0.89 and significant correlation with cGVHD diagnosis, cGVHD severity, and nonrelapse mortality. In a second verification cohort, this panel distinguished patients with cGVHD (AUC, 0.75), and finally, the panel measured at day +100 could predict cGVHD occurring within the next 3 months with an AUC of 0.67 and 0.79 without and with known clinical risk factors, respectively.We conclude that the biomarker panel measured at diagnosis or day +100 after HCT may allow patient stratification according to risk of cGVHD.
Discordant Grading of Aortic Stenosis Severity
Authors: Maxime Berthelot-Richer, Philippe Pibarot, Romain Capoulade, Jean G. Dumesnil, Abdellaziz Dahou, Christophe Thebault, Florent Le Ven, Marie-Annick Clavel
Journal: JACC. Cardiovascular imaging (2016)
EPIG-15MicroRNA EXPRESSION HETEROGENEITY IN GLIOBLASTOMA
Authors: Joshua Branter, Jennifer Ward, Ruman Rahman, Stuart Smith
Journal: Neuro-Oncology (2015)

Intratumor heterogeneity exists in many cancers, with clear evidence of differential gene expression temporo-spatially in glioblastoma multiforme (GBM). MicroRNA (miRNA) profiling studies have identified risk-stratifying signatures in GBM, but it has not been clarified whether microRNA profiles vary in a similar fashion to gene expression within individual GBM tumors. This study utilized primary GBM specimens resected from patients undergoing surgery in a regional UK Neurosurgery unit. Fresh frozen tissue underwent RNA extraction and miScript Human Brain Cancer miRNA PCR Array was used to assess 84 miRNA's expression levels between distinct spatial regions within primary GBMs. miRNA expression was analyzed with quantitative RT-PCR and gene targets for analysis were selected with miRtarget gene prediction software. Protein levels for the in silico predicted targets based on miRNA expression were validated through immunohistochemistry (IHC). A large degree of intratumor heterogeneity was apparent in the samples. Homology existed between individuals with 8 common miRNAs differentially expressed between central and edge regions of tumors. Protein levels of CDK6 and c-KIT nuclear accumulation were significantly elevated at tumor edges relative to core samples in concordance with the microRNA profiling. Intratumor heterogeneity in GBM produces significant miRNA profiling variation depending on spatial location of the sample within the tumor. Therefore, assessment of GBM miRNA signatures requires selective sampling from multiple distinct tumor regions and consideration of the overall patterns of miRNA expression across the entirety of the tumor.
Influence of α Keto Acids on the Desamidation of Amino Acid Amides
Authors: Jesse P. Greenstein, Charles E. Carter
Journal: JNCI Journal of the National Cancer Institute (1946)

Journal Article Influence of α Keto Acids on the Desamidation of Amino Acid Amides Get access Jesse P. Greenstein, Jesse P. Greenstein principal biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles E. Carter Charles E. Carter assistant surgeon National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 2, October 1946, Pages 57–60, https://doi.org/10.1093/jnci/7.2.57 Published: 01 October 1946 Article history Received: 17 September 1946 Published: 01 October 1946
Gastroesophageal Reflux Disease and Barrett's Esophagus
Authors: G W Falk
Journal: Endoscopy (2001)

Gastroesophageal reflux disease (GERD) is a common clinical problem. Circumstantial evidence continues to suggest that infection with Helicobacter pylori may protect some patients from developing GERD and its complications. An empirical trial of a proton-pump inhibitor may now be a reasonable alternative to endoscopy or 24-hour pH testing for the diagnosis of GERD. Long-term follow-up data covering more than over a decade indicate that proton-pump inhibitors are effective and safe agents for the treatment of GERD. Furthermore, a strategy of proton-pump inhibitors first may be the most cost-effective approach to GERD. It remains unclear why some patients with GERD develop Barrett's esophagus, whereas others do not. Recent studies demonstrate the importance of pulses of acid or bile in increasing cell proliferation and cyclooxygenase-2 expression in Barrett's epithelium cell cultures. Short-segment Barrett's esophagus is now clearly associated with an increased risk of dysplasia or cancer compared to intestinal metaplasia of the cardia, and the cancer risk in this condition is similar to that with long-segment Barrett's esophagus. However, the overall cancer risk in patients with Barrett's esophagus is lower than previously estimated, at approximately 0.5% annually. Ablation techniques continue to show promise, but are not yet ready for routine clinical use. Endoscopic mucosal resection is a new treatment option for selected patients with high-grade dysplasia or superficial esophageal adenocarcinoma.
Effects of Nurse Management on the Quality of Heart Failure Care in Minority Communities
Authors: Jane E. Sisk, Paul L. Hebert, Carol R. Horowitz, Mary Ann McLaughlin, Jason J. Wang, Mark R. Chassin
Journal: Annals of Internal Medicine (2006)

This 12-month trial of assistance with managing systolic-dysfunction heart failure randomly assigned 406 ethnically diverse adults from Harlem, New York, to usual care or nurse management. Nurse ma...