Surveying the Landscape of Ovarian Cancer Research and Care
Authors: Ronald D. Alvarez, Jerome F. Strauss
Journal: Annals of Internal Medicine (2016)

Ideas and Opinions20 September 2016Surveying the Landscape of Ovarian Cancer Research and CareRonald D. Alvarez, MD, MBA and Jerome F. Strauss III, MD, PhDRonald D. Alvarez, MD, MBAFrom the University of Alabama at Birmingham, Birmingham, Alabama, and Virginia Commonwealth University, Richmond, Virginia.Search for more papers by this author and Jerome F. Strauss III, MD, PhDFrom the University of Alabama at Birmingham, Birmingham, Alabama, and Virginia Commonwealth University, Richmond, Virginia.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0604 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail On 2 March 2016, the National Academies of Science, Engineering, and Medicine released a congressionally mandated report, sponsored by the Centers for Disease Control and Prevention, that assessed the state of research on ovarian cancer and its subtypes (1). The report originates from the Gynecologic Cancer Education and Awareness Act, more commonly known as Johanna's Law, named after Johanna Silver Gordon, who died of ovarian cancer. The findings and 11 recommendations of the report address the challenges and opportunities in ovarian cancer research relevant to all professionals who care for women and their families. Here, we summarize selected findings and ...References1. National Academies of Sciences, Engineering, and Medicine. Ovarian Cancers: Evolving Paradigms in Research and Care. Washington, DC: National Academies Pr; 2016. Accessed at www.nas.edu/OvarianCancers on 2 May 2016. Google Scholar2. Kurman RJ, Shih IeM. The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory. Am J Surg Pathol. 2010;34:433-43. [PMID: 20154587] doi:10.1097/PAS.0b013e3181cf3d79 CrossrefMedlineGoogle Scholar3. George R, Kovak K, Cox SL. Aligning policy to promote cascade genetic screening for prevention and early diagnosis of heritable diseases. J Genet Couns. 2015;24:388-99. [PMID: 25577298] doi:10.1007/s10897-014-9805-5 CrossrefMedlineGoogle Scholar4. Jacobs IJ, Menon U, Ryan A, Gentry-Maharaj A, Burnell M, Kalsi JK, et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet. 2016;387:945-56. [PMID: 26707054] doi:10.1016/S0140-6736(15)01224-6 CrossrefMedlineGoogle Scholar5. Daly MB, Dresher CW, Yates MS, Jeter JM, Karlan BY, Alberts DS, et al. Salpingectomy as a means to reduce ovarian cancer risk. Cancer Prev Res (Phila). 2015;8:342-8. [PMID: 25586903] doi:10.1158/1940-6207.CAPR-14-0293 CrossrefMedlineGoogle Scholar6. Bristow RE, Chang J, Ziogas A, Anton-Culver H, Vieira VM. Spatial analysis of adherence to treatment guidelines for advanced-stage ovarian cancer and the impact of race and socioeconomic status. Gynecol Oncol. 2014;134:60-7. [PMID: 24680770] doi:10.1016/j.ygyno.2014.03.561 CrossrefMedlineGoogle Scholar7. Fong PC, Boss DS, Yap TA, Tutt A, Wu P, Mergui-Roelvink M, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med. 2009;361:123-34. [PMID: 19553641] doi:10.1056/NEJMoa0900212 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Alabama at Birmingham, Birmingham, Alabama, and Virginia Commonwealth University, Richmond, Virginia.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0604.Corresponding Author: Ronald D. Alvarez, MD, MBA, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 1700 6th Avenue South, Birmingham, AL 35233; e-mail, [email protected]edu.Current Author Addresses: Dr. Alvarez: Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 1700 6th Avenue South, Birmingham, AL 35233.Dr. Strauss: Department of Obstetrics and Gynecology, Virginia Commonwealth University, 1201 East Marshall Street, Richmond, VA 23298.Author Contributions: Conception and design: R.D. Alvarez.Drafting of the article: R.D. Alvarez, J.F. Strauss.Critical revision of the article for important intellectual content: R.D. Alvarez.Final approval of the article: R.D. Alvarez, J.F. Strauss.Administrative, technical, or logistic support: R.D. Alvarez.Collection and assembly of data: J.F. Strauss.This article was published at www.annals.org on 17 May 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 20 September 2016Volume 165, Issue 6Page: 439-440KeywordsCancer preventionCancer screeningChemotherapyMortalityObstetrics and gynecologyOvarian cancerOvarian cancer screeningOvariesRisk assessmentsUltrasound imaging ePublished: 17 May 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...