tbuckley/cabot-search huggingface dataset:
Measurement of Circulation Times with NaI <sup>131</sup>
Authors: REGINALD A. SHIPLEY, RICHARD E. CLARK
Journal: Circulation Research (1956)

Circulation time from an arm vein to the femoral artery as determined with I 131 averaged 11.2 seconds in normal male adults. In the presence of heart failure the time of initial arrival was prolonged, and the slope of ensuing rise flattened. Decholin time, determined simultaneously, averaged 25 per cent longer than I 131 time in both normal subjects and patients with congestive failure. Theoretical considerations indicate that arrival time measured with a radioactive tracer is less affected by cardiac dilatation than is arm to tongue time obtained with Decholin. Arm to heart time measured with I 131 was prolonged in the presence of failure but marked overlap with normal subjects was evident.
Old Genes Settle Dispute Over Saber-Tooth Cat's Clan
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Old Genes Settle Dispute Over Saber-Tooth Cat's Clan Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 21, 4 November 1992, Pages 1617–1618, https://doi.org/10.1093/jnci/84.21.1617 Published: 04 November 1992
Government Patents: Is There Money To Be Made?
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1988)

Government Patents: Is There Money To Be Made? Get access Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 20, 21 December 1988, Pages 1588–1590, https://doi.org/10.1093/jnci/80.20.1588 Published: 21 December 1988
AB0924 Charcot Arthropathy: A Diagnostic Challenge in Diabetic Patients. Clinical Features of 21 Cases
Authors: E. Casado, M. Arévalo, O. Giménez, C. Orellana, E. Graell, C. Galisteo, M. Larrosa
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Charcot arthropathy is a destructive arthropathy with severe bone resorption that occurs in patients with sensory neuropathy of any etiology. This arthropathy can be a diagnostic challenge, because it has little clinical expression and requires to be suspected by specialists not used to assess patients with joint pathology. <h3>Objectives</h3> To analyze the clinical features of patients with Charcot arthropathy diagnosed in our department in the last years. <h3>Methods</h3> We systematically reviewed cases with Charcot arthropathy diagnosed in our department in the last 12 years (2002-2013). Demographics, underlying disease, time since onset of the arthropathy, clinical characteristics and referral department were collected. <h3>Results</h3> 21 cases of Charcot arthropathy (57% male), age 55.8 years (29-78) were confirmed. The underlying disease was 15 diabetes, 2 syringomyelia, 2 leprosy 1 Charcot-Marie-Tooth, and 1 idiopathic sensory autonomic polyneuropathy. Patients with diabetes had a disease of 13.5 years of evolution (range 1-25). Of these patients 73% had peripheral vascular disease and 93% almost had one cardiovascular risk factor. The patients came mainly from Endocrinology (34%). Other referral departments were: Emergency (16%), Vascular Surgery (14%), Podiatry (14%), Internal Medicine (9%), Neurology (5%) and Orthopaedics (5%). We observed a delayed diagnosis of the arthropathy, with a mean of 360 days (4-1500). The most common form of clinical presentation was: swelling (57%), mild pain (52%), deformity (38%), fracture (1 patient). In 1 patient the diagnosis was casual (radiological finding). Most patients (57%) had a trigger: local infection (58%), surgery (25%) or injury (17%). The most common site in patients with diabetes was the tarsus (87%). <h3>Conclusions</h3> Charcot arthropathy is mostly seen in patients with long-standing diabetes with peripheral vascular disease associated with other cardiovascular risk factors. Patients come mostly from Endocrinology, and although half of the patients had a trigger there is a clear diagnostic delay. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4001
P95 Cost effectiveness of overnight face-to-face nurse led COPD service
Authors: D. Green, O. Hampson, S. Agarwal, S. Church
Journal: Thorax (2011)

<h3>Background</h3> Prevalence of Chronic Obstructive Pulmonary Disease (COPD) is twice the UK average with emergency admission rate 175% higher in Knowsley Primary Care Trust (PCT). A primary care nurse led COPD service was initially operational from 08:00 to 10:00, thereafter telephone advice was available overnight for management of patients with exacerbation of COPD. This was later commissioned by the PCT to provide a 24 h, 365 days face-to-face rapid response contact assessment at home or in the Accident and Emergency department. The Nurses were contracted to assess the patients within 2 h of the contact. Following this, staffing levels needed to be considerably increased. This development led to an increased burden on the COPD service. <h3>Aim</h3> To assess the cost-effectiveness of the this new service provision as contracted to direct further commissioning and planning within the restricted budget. <h3>Methods</h3> A database of patients with confirmed diagnosis of COPD was setup. The database included 3500 patients. They were provided with contact numbers in an event of exacerbation. Activity was monitored over 24 h from September 2009 to July 2010 (10 month9s duration). Data were analysed using Excel. <h3>Results</h3> 399 contacts made over the study period. The majority of the first contacts (18%) were on Mondays during the day hours. Another 17% first contacts were made over the weekends. 62 patients (15%) made contact overnight from 23:00 to 08:00 over the 10 months duration. Only 17 home visits were required and 45 patients reviewed in A&amp;E. Of the patients reviewed in A&amp;E only five were suitable for supported discharge. <h3>Conclusion</h3> Overnight face-to-face COPD nurse led service was not found to be cost-effective. This provides valuable information to inform the COPD national strategy consultation in development for further services.
Oncology Professions Transformed in 20 Years: Patients Benefit
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Oncology Professions Transformed in 20 Years: Patients Benefit Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 9, 1 May 1991, Pages 596–598, https://doi.org/10.1093/jnci/83.9.596 Published: 01 May 1991
Abstract 2271: Dabigatran etexilate blocks breast cancer progression in vitro and in a 4T1 breast cancer tumor model in mice
Authors: Karen DeFeo, Candace S. Hayes, Joanne Van Ryn, Susan K. Gilmour
Journal: Cancer Research (2010)

Abstract Introduction: Coagulation proteases and the generation of thrombin are increased in tumors. Thrombin can modify tumor cell behavior directly through the activation of protease-activated receptors (PAR) or indirectly by generating fibrin matrices. Aim: To test the hypothesis that dabigatran etexilate (Pradaxa®), an oral direct thrombin inhibitor, can prevent the progression of tumor cells in experimental models. Materials and Methods: The effect of dabigatran on invasiveness of MDA-MB-231 breast carcinoma cells was evaluated in vitro by invasion across Matrigel-coated membranes and in vivo using a tracheal xenotransplant invasion assay in athymic nude mice. To evaluate the effect of dabigatran on the development of metastatic foci, 4T1 tumor cells were injected orthotopically in the mammary fat pads of syngeneic Balb/c mice. Tumor growth and metastasis was monitored weekly. Dabigatran etexilate was administered twice daily at a dose of 45 mg/kg over 4 weeks in all in vivo models. Results: Whereas dabigatran had no effect on the proliferation index of cultured tumor cells, it inhibited invasiveness of MDA-MB-231 cells across Matrigel-coated membranes. In vivo evaluation of invasiveness of MDA-MB-231 cells in tracheal xenotransplants in mice administered dabigatran for 3 and 4 weeks demonstrated significantly less penetration of tumor cells through the tracheal wall. Dabigatran treatment had a modest inhibitory effect on growth of the primary 4T1 mammary carcinoma (∼50% reduction in tumor volume at 4 weeks) in syngeneic Balb/c mice, and it reduced both 4T1 tumor cells in the blood and liver micrometastases by 50-60%. Dabigatran treatment resulted in no weight loss in mice. Conclusion: Oral administration of the direct thrombin inhibitor, dabigatran etexilate, inhibits both invasion and metastasis of malignant breast tumors, suggesting that dabigatran may be beneficial in not only preventing thrombotic events in cancer patients, but also as adjunct therapy to treat malignant tumors. (Supported by funds from Boehringer Ingelheim Pharma) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2271.
O146 INTESTINAL DYSBIOSIS EXPLAINS INTER-INDIVIDUAL DIFFERENCES IN SUSCEPTIBILITY TO ALCOHOLIC LIVER DISEASE
Authors: M. Llopis, A.M. Cassard-Doulcier, L. Boschat, A. Bruneau, F. Cailleux, S. Rabot, F. Gaudin, D. Berrebi, S. Naveau, P. Gérard, G. Perlemuter
Journal: Journal of Hepatology (2014)
AB0307 Low prevalence of methotrexate intolerance in patients with rheumatoid and psoriatic arthritis
Authors: M. Bulatovic Calasan, O.F. van den Bosch, M.C. Creemers, M. Custers, T.H. Heurkens, J.M. van Woerkom, N.M. Wulffraat
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Methotrexate (MTX)-related gastrointestinal adverse effects are very common during MTX treatment in patients with juvenile idiopathic arthritis (1). JIA patients also develop adverse effects occurring before MTX intake and when thinking of MTX and behavioral complaints as conditioned responses to physical complaints experienced after MTX intake. Although MTX is the most commonly used anti-rheumatic in rheumatoid (RA) and psoaritic (PsA) arthritis as well, it is unknown whether the abovementioned MTX-related gastrointestinal adverse effects occur as frequently in adults. <h3>Objectives</h3> To determine the prevalence of MTX-related gastrointestinal and behavioral adverse effects, termed MTX intolerance, in RA and PsA patients using the previously validated Methotrexate Intolerance Severity Score (MISS) (1) <h3>Methods</h3> We performed a cross-sectional multicenter descriptive study in patients visiting three outpatient rheumatology clinics in The Netherlands. MTX intolerance was measured using the MISS, which assessed (i) adverse effects after MTX intake, (ii) adverse effects before MTX intake ("anticipatory"), (iii) adverse effects when thinking of MTX ("associative") and (iv) behavioral adverse effects. These adverse effects included nausea, abdominal pain, vomiting and behavioural symptoms of restlessness, irritability and drug refusal. MTX intolerance was defined as ≥6 points on the MISS, with at least 1 point on anticipatory, associative or behavioral adverse effects. <h3>Results</h3> Of the 170 consecutive patients, 66 patients (38.8%) reported adverse effects. According to the definition, MTX intolerance was found in 14 patients (8.2%). The prevalence of MTX intolerance was higher in patients using parenteral MTX than in patients using oral MTX (n=9 [27.2%] vs n=5 [3.6%]; <i>p</i> &lt;0.001). <h3>Conclusions</h3> Despite the fact 38.8% of patients reported adverse effects, only 8.2% of patients were intolerant to MTX according to the definition. This is remarkably less than the prevalence of MTX intolerance in JIA patients, which reached up to 50.5% (1). This was due to a significantly lower prevalence of both post-treatment and pre-treatment adverse effects in RA and PsA patients. <h3>References</h3> Bulatovic M, Heijstek MW, Verkaaik M, van Dijkhuizen EHP, Armbrust W, Hoppenreijs EP et al. High prevalence of methotrexate intolerance in juvenile idiopathic arthritis: development and validation of a methotrexate intolerance severity score. Arthritis Rheum 2011; 63(7):2007-2013. <h3>Disclosure of Interest</h3> None Declared
Complete Bile Duct Sequestration after Liver Transplantation, Caused by Ischemic-Type Biliary Lesions
Authors: H.  Abou-Rebyeh, W.  Veltzke-Schlieker, C.  Radke, T.  Steinmüller, B.  Wiedenmann, R.  E.  Hintze
Journal: Endoscopy (2003)

Ischemic-type biliary lesions (ITBLs) are the most frequent cause of nonanastomotic biliary strictures in liver grafts, affecting about 2-19 % of patients after liver transplantation. ITBL is characterized by bile duct destruction, subsequent stricture formation, and sequestration. We report here the case of a patient affected by extremely severe ITBL, with sequestration and disintegration of the entire bile duct system, in which it was possible to extract the complete biliary tree endoscopically in a single piece. Histological examination revealed that all cells of the bile duct wall had been destroyed within 3 months after liver transplantation and replaced by connective tissue. Subsequently, biliary stricture formation occurred at the hepatic hilum, as well as the adjacent large bile ducts. It may be hypothesized that cellular rejection of small bile ducts leads to the vanishing bile duct syndrome, whereas cellular rejection of large bile ducts results in ITBL. The strictures were repeatedly dilated by endoscopic means, allowing successful control of stricture formation, as well as maintenance of liver function. At the time of writing, the grafted organ and the patient had survived for more than 3 years in good health. This is the first detailed report on a sequestration of the entire bile duct system caused by ITBL, successfully treated for several years by endoscopic means.
Abstract 5020: Role of LIN28 in aggressive breast cancers lacking REST
Authors: Kearney T.W. Gunsalus, Matthew P. Wagoner, Wyatt B. Potter, Barry Schoenike, Avtar Roopra
Journal: Cancer Research (2010)

Abstract Our lab has discovered a highly aggressive subset of breast cancers characterized by a lack of function of the tumor suppressor RE1 Silencing Transcription Factor (REST). REST is a transcriptional repressor controlling over 2000 neuronal genes, and has been identified as a tumor suppressor in lung and colon cancers. Our lab has discovered that REST function is lost in 20% of breast tumors and that its loss is associated with a significantly decreased disease-free survival and poor prognosis (Wagoner et al. poster, this meeting, CB4). In addressing the mechanisms underlying the aggressiveness of these RESTless tumors, we found that expression of the tumor promoter LIN28 is upregulated. We describe the direct regulation of LIN28 by REST in a range of mammary cell lines and show a correlation between REST loss and LIN28 overexpression in breast tumors. LIN28 inhibits maturation of the tumor suppressor microRNA let-7, which in turn suppresses expression of the oncogenes Myc and Ras. LIN28 overexpression has been found to promote metastasis in a mouse xenograft model of breast cancer. To examine the effects of REST loss and LIN28 expression on cellular transformation and motility, we have knocked down REST and LIN28 in a variety of breast cell lines (including T47D, MCF7, MDA-MB-231, 3T3 and NMuMG cells). Here, we describe the results of our colony formation, soft agar growth and motility assays. We recapitulate in vitro aspects of tumor aggression seen in the patient population, and we find that these processes are promoted by REST loss in a LIN28-dependent manner. We also describe xenograft models looking at the growth and metastasis of tumors that express or lack REST and LIN28. We conclude that REST loss promotes tumor aggressiveness at least in part via upregulation of its target gene LIN28. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5020.
Jumping to the Wrong Conclusion
Authors: Yaron Elad, Peter J. Nelson, Diane E. Meier
Journal: New England Journal of Medicine (1998)

An 82-year-old woman was brought to the emergency department by her daughters because of deterioration in her mental capabilities over a period of three months. She had become increasingly forgetful and occasionally got lost in her own neighborhood. On the morning of her admission, she had called one of her daughters at work in an agitated and disoriented state, which resolved spontaneously. The patient's daughters reported that one week earlier she had had slightly slurred speech, dizziness, and right-sided facial droop for a day. She had also fallen on her right side two weeks earlier and reported having a . . .
NI-65 * DIFFERENTIATING RADIATION EFFECT AND NECROSIS FROM GLIOBLASTOMA WITH DYNAMIC SUSCEPTIBILITY CONTRAST (DSC) MRI
Authors: M. Prah, M. Al-Gizawiy, W. Mueller, R. Hoffmann, K. Schmainda
Journal: Neuro-Oncology (2014)

BACKGROUND: In glioblastoma (GBM), pseudoprogression (PsP) appears as increased enhancement on T1-weighted imaging following concurrent chemoradiotherapy (CRT), making it difficult to distinguish from true progression. This increased enhancement, due to radiation and necrotic induced changes, is associated with effective treatment response. The goal of this study was to determine the ability of measures derived from dynamic susceptibility contrast (DSC) MRI to distinguish radiation effect (RE) and necrosis from GBM. METHODS: All patients gave informed written consent according to IRB policy. Thirty-three tissue samples from 11 previously treated patients were spatially correlated to MRI with a median = 13 days between surgery and MRI. Preload and leakage-corrected metrics of DSC-MRI were co-registered with the pre-surgical Stealth exam, and positive, median values of standardized (sRCBV) or normalized (nRCBV) relative cerebral blood volume, and normalized relative cerebral blood flow (nRCBF) were obtained within 3-mm regions precisely matched to the surgically recorded biopsy locations. Statistical analysis included generalized estimating equations (to account for multiple samples from the same subject) with receiver operator characteristic curves. RESULTS: Gender and median age were similar between tissue groups. Pathologic diagnosis confirmed 11 samples with pure RE/Necrosis and 22 samples with pure GBM. All metrics showed significant differences between RE/Necrosis and GBM (p < 0.001). Interestingly, both sRCBV and nRCBV showed equally higher sensitivity and specificity (81.8%/90.9%, thresholds = 4287 and 1.32, respectively) than nRCBF (72.7%/81.8%, threshold = 1.13) for differentiating RE/Necrosis and GBM. CONCLUSIONS: Accurate assessment of treatment response using measures of DSC-MRI is promising, as these measures show high sensitivity and specificity for differentiating RE/Necrosis and GBM. Both nRCBV and sRCBV provide equally greater accuracy than nRCBF. Visualizing these differentiated regions on imaging could help clinicians better assess treatment response following CRT, with potential to impact treatment management decisions.
Abstract 3225: Cellular and in vivo models for the analyses of B-Raf and c-Src inhibitors
Authors: Jan E. Ehlert, Bettina Mutschler, Melanie Müller, Andreas Lingnau, Steffen Hoffmann, Michael HG Kubbutat
Journal: Cancer Research (2010)

Abstract Cytosolic kinases c-Src and B-Raf represent proto-oncogenes of which mutant or overexpressed variants have been shown to cause cancer. Efforts are taken to develop inhibitors specifically addressing these kinases, some of which have already been approved such as Src inhibitor Dasatinib and BRaf inhibitor Sorafenib. In the current study we have generated cellular systems to allow for the analyses of Src and BRaf inhibitors in kinase specific cellular phosphorylation assays as well as in subcutaneous in vivo models. For both kinases we are introducing in vivo models allowing for regulatable kinase activity and thereby regulatable, kinase dependent tumor growth. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3225.
Case 39-2002
Authors: William F.C. Rigby, Chieh-Min Fan, Eugene J. Mark
Journal: New England Journal of Medicine (2002)

Presentation of CaseA 35-year-old right-handed man was admitted to the hospital because of a persistent headache and deviation of the tongue.The patient had been in excellent health until about one month earlier, when a left-sided headache developed, with occasional bright spots in the left visual field, subjective fever, chilliness, and anorexia; he lost 5 kg of body weight at this time. The headache became severe and was not affected by nonsteroidal antiinflammatory agents, the patient's position, straining, or coughing. During this period, his tongue deviated to the left and caused drooling, although he had no dysphasia or dysphagia. . . .
THE USE OF CO2 CONTRAST CAN PREVENT DETERIORATION OF RENAL FUNCTION FOR ENDOVASCULAR THERAPY REGARDLESS OF RENAL FUNCTION
Authors: Ryuta Sugihara, Yoshio Yasumura, Kazunori Kashiwase, Yoshiharu Higuchi, Akio Hirata, Yuji Nishimoto, Koushi Matsuo
Journal: Journal of the American College of Cardiology (2016)
Radioguided Surgery of Thyroid Carcinoma Recurrences
Authors: Luca Giovanella, Sergio Suriano, Lara Lunghi, Massimo Bongiovanni, Luca Ceriani
Journal: Clinical Nuclear Medicine (2013)

Reoperative surgery in the neck for recurrent differentiated thyroid cancer (DTC) is associated with increased morbidity compared with primary surgery. Radioguided occult lesion localization was recently proposed in patients with DTC recurrences. Here we report on the combination of radioguided occult lesion localization procedure to preoperative SPECT/CT in 2 patients with DTC recurrences. This combination was proved to be simple and technically feasible. Addition of SPECT/CT to conventional preoperative planar scans provided an accurate 3-dimensional road map for neck exploration.
LONG-TERM COMPLIANCE OF SECONDARY PREVENTION TREATMENT - FEMALES AND MALES WITH STABLE ANGINA IN CLINICAL PRACTICE: RESULTS OF THE STAR-REGISTRY
Authors: Anselm K. Gitt, Jan Karcher, Uwe Zeymer, Steffen Schneider, Ralf Zahn, Jochen Senges
Journal: Journal of the American College of Cardiology (2015)