tbuckley/cabot-search huggingface dataset:
PWE-154 Iron Deficiency Anaemia as an Indicator of Malignancy - The Idiom Study: Abstract PWE-154 Table 1
Authors: A Castro-Silva, Z A Sheppard, S L Surgenor, E J Williams, J A Snook
Journal: Gut (2013)

<h3>Introduction</h3> Iron deficiency anaemia (IDA) is common. It is of particular importance because about 10% of subjects with IDA over the age of 50 will have an underlying gastro-intestinal (GI) malignancy, often in the absence of other clinical pointers to the diagnosis. IDA is therefore an accepted indication for examination of the GI tract, generally through bidirectional endoscopy. Investigation of IDA is labour-intensive however, and most examinations will not reveal significant pathology. The aim of this study was to determine whether simple and objective clinical variables can identify sub-groups of subjects with IDA who are at clinically useful extremes of risk for underlying malignancy – arbitrarily defined as &lt; 1% for low risk and &gt; 20% for high risk. <h3>Methods</h3> A retrospective study of 720 subjects referred to a single IDA clinic between 2004 and 2012. All had confirmed iron deficiency, minor or no localising symptoms, and subsequent GI tract investigation. Recorded information included age, sex, haemoglobin concentration (Hb), mean cell volume (MCV), iron studies, and final diagnosis. <h3>Results</h3> A total of 68 (9.4%) of the study population had a GI malignancy. In the model generated by logistic regression analysis, age (&gt; 70 v &lt; 71), sex (M v F) and Hb quartile were all predictive of the probability of underlying malignancy. The effects of these variables were cumulative. Percentage of cases of GI malignancy in each subgroup (cases/number in subgroup): The prevalence of GI malignancy ranged from 0.0% in younger females with mild anaemia, to over 25% in older males with more severe anaemia. By the pre-defined criteria, the model identified sub-populations of 84 (11% of the total) at extreme low risk, and 117 (16%) at extreme high risk. <h3>Conclusion</h3> The results confirm previous work identifying age, sex and haemoglobin concentration as variables predictive of underlying malignancy in IDA. Furthermore, the findings suggest that over a quarter of subjects with IDA can be predicted to be of extremely low or high risk on the basis of these simple and objective clinical criteria. This may be of clinical relevance for patient counselling, prioritisation of investigations and allocation of resources. Work is ongoing to validate risk prediction in a prospective study, and to refine the model by inclusion of additional variables. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> James MW, Chen CM, Goddard WP, Scott BB, Goddard AF. Risk factors for gastrointestinal malignancy in patients with iron deficiency anaemia. Eur J Gastroenterol Hepatol 2005; 17(11):1197–203.
AB0153 Effect and Mechanism of Intestinal Clostridium on the Development of Rheumatoid Arthritis
Authors: Y. Fang, X. Liu, H. Wu
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The study evaluated the relationship between conditioned pathogen clostridium and rheumatoid arthritis (RA) using collagen-induced arthritis (CIA) animal model. <h3>Methods</h3> SPF DBA/1 mice were randomly divided into 4 groups (n=6). Enema administration of clostridium which were from RA patients was started on 2 weeks before injection of the II collagen in Mouse and lasted for 5 weeks. Mouse was sacrificed 13 weeks after injection of the II collagen. Serum level of TNF-α, IL-1β and IL-23 were observed, and four-point arthritis indexes were also assessed. Knee joints were assessed according to the histopathology. <h3>Results</h3> Arthritis incidence, the number of arthritic limbs per arthritic mouse and the arthritic severity scores were higher in CIA-Clostridium group than the CIA group after the 13 weeks of the immunization, however, the difference was not statistically significant (<i>P</i>&gt;0.05). As compared with the CIA (TNF-α: 239.7±59.9pg/ml, IL-1β: 190.0±55.0pg/ml), the TNF-α: (301.1±19.2pg/ml, <i>P</i> &lt;0.01) and IL-1β (247.2±32.0pg/ml, <i>P</i>&lt;0.05) were significantly increased. <h3>Conclusions</h3> Present research suggests that Clostridium may not induce the arthritis directly. Enema administration of Clostridium may have effect on the disease, but the effect was not statistically significant. Clostridium vaccination combining collagen-induced could significantly increase the level of cytokines in peripheral blood of CIA mice, such as TNF-αand IL-1β. <h3>References</h3> Vaahtovuo, J., et al., Fecal microbiota in early rheumatoid arthritis. J Rheumatol, 2008. 35(8): p. 1500-5. Brand, D.D., K.A. Latham, and E.F. Rosloniec, Collagen-induced arthritis. Nat Protoc, 2007. 2(5): p. 1269-75. van de Loo, F.A., et al., Role of interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum, 1995. 38(2): p. 164-72. Zhang, F., G. Meng, and W. Strober, Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells. Nat Immunol, 2008. 9(11): p. 1297-306. Cua, D.J., et al., Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature, 2003. 421(6924): p. 744-8. Murphy, C.A., et al., Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med, 2003. 198(12): p. 1951-7. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1094
Case 17-2001
Authors: R. Scott Harris, Eugene J. Mark
Journal: New England Journal of Medicine (2001)

Presentation of CaseA 42-year-old man was admitted to the hospital because of pulmonary cysts.The patient had a long history of nasal allergy, with occasional wheezing on exposure to cats; hives after ingestion of shellfish; dry eyes and mouth; and occasional swelling and stiffness of the left hand and right wrist. Eleven years before admission, a biopsy of his lower lip showed prominent chronic sialadenitis, a finding consistent with the diagnosis of Sjögren's syndrome.Nine years before admission, the patient was found to have a high titer of antinuclear antibodies with a speckled pattern, with positive tests for rheumatoid . . .
Cervical screening should continue after age 65, study concludes
Authors: I. Torjesen
Journal: BMJ (2014)

Consideration should be given to raising the upper age at which women are offered cervical screening above 65 years to take account of increasing life expectancy, research has suggested.

The study, published in PLOS Medicine , confirmed that screening women for cervical cancer beyond the age of 50 saved lives but added that there were also benefits to screening women up to the age of 69.1

Under the NHS in England’s cervical screening programme women are invited for cervical screening every three years from the age of 25 to 50 and then every five years until 65.

The researchers, …
AB1177-HPR Occupational Characterization in A Cohort of Rheumatoid Arthritis Patients – Correlation with Disease Activity and Functional Status
Authors: D. Beltran, G. Saavedra-Martinez, L. Villarreal, A. Palomino, J. Bello-Gualtero, P. Santos-Moreno
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Rheumatoid arthritis (RA) is a disease that in most cases is associated with disability and loss of earning capacity. There is a lack of information about occupation of rheumatoid arthritis patients in Colombia, being this field important in order to improve clinical and social outcomes for them. Also is not studied correlation with disease activity and disability. <h3>Objectives</h3> The aim of this study was to describe the occupation of a cohort of RA patients and its possible relationship with disease activity and functionality in a specialized center in Colombia. <h3>Methods</h3> A descriptive cross sectional study was realized. A revision of medical records of a cohort of RA patients was performed, including occupational therapy records. Each patient was evaluated for DAS28, HAQ and OPHI2 (Occupational Performance History Interview 2). Descriptive epidemiology was done, percentages and averages were calculated; Pearson9s statistics was used for by-variated analysis. <h3>Results</h3> Of the 139 RA patients included, 27 (19.4%) were men and 112 (80.6%) women. Mean age 56.1±9 years, for women 55.9 years and for men 57 years. Average DAS 28 for all patients 3.01, (2.5 for women and 2.63 for men), average HAQ were 0.36 (0.43 for women and 0.39 for men). Most frequent occupations (percentage, DAS 28 and HAQ means) were: low impact work 57 (41%, 2.6, 0.44); domestic work 36 (25.9%, 2.43, 0.37); administrative work 31 (22.3%, 2.13, 1.00). It was not established correlation between occupation and disease activity or functionality. <h3>Conclusions</h3> Interestingly most active RA patients were kindergarten teachers with an average moderate disease activity, followed by sewing operators. Less active disease scores were found on floriculture workers. In regard of functional status, sewing operators had higher scores followed by housekeepers; but in general for all types of occupations HAQ scores were low. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4775
P38 CIRRHOTIC ENDOTHELIAL PROGENITOR CELLS (EPCS) ENHANCE LIVER FIBROSIS AND ANGIOGENESIS IN BILE DUCT LIGATED RATS
Authors: D.M. Tripathi, M.H. Bhat, S. Gupt, N. Sharma, C. Bihari, S. Kaur, S.K. Sarin
Journal: Journal of Hepatology (2014)
Abstract 1218: SMAC modulates gemcitabine-induced apoptosis in head and neck cancer cells
Authors: Quanhong Sun, Lin Zhang, Jian Yu
Journal: Cancer Research (2010)

Abstract Apoptosis induction is an important anti-tumor mechanism of many conventional chemotherapeutic agents. Biochemical data indicate that SMAC promotes caspase activation by antagonizing IAPs. However, SMAC-knockout mice do not exhibit obvious apoptotic deficiencies in response to a wide range of stimuli. Work for us and others demonstrate that SMAC plays an essential role in apoptosis induced by Nonsteroidal Anti-inflammatory Drug (NSAID), TRAIL or BH3 only proteins in colon cancer cells. In this study we documented a critical role of SMAC in mediating apoptosis induced by chemotherapeutic agent gemcitabine in head and neck squamous cell carcinoma (HNSCC) cells. Using RNA interference, we found that that SMAC mediates gemcitabine-induced apoptosis through the intrinsic/mitochondrial pathway. SMAC Knockdown led to impairment in caspase-3 activation, mitochondrial membrane depolarization and release of cytochrome c. Small-molecule SMAC mimetics at nanomolar concentrations significantly sensitized HNSCC cells to gemcitabine-induced apoptosis, and overcame gemcitabine resistance in SMAC-knockdown cells by restoring caspase-3 activation and cytochrome c release. Furthermore, in xenograft models, SMAC knockdown significantly blocked the therapeutic responses of HNSCC tumors to gemcitabine by inhibiting apoptosis, while SMAC overexpression dramatically enhanced that. Together, these results suggest that SMAC mediates apoptosis in cancer cells, and provide a strong rationale for combining SMAC mimetics with other anticancer agents to treat apoptosis-resistant tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1218.
RISK FACTORS AND OUTCOME OF VENTRICULAR FIBRILLATION BEFORE AND DURING PRIMARY ANGIOPLASTY AMONG PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Reza Jabbari, Bjarke Risgaard, Emil Fosbøl, Thomas Scheike, Bo Gregers Winkel, Christine Albert, Charlotte Glinge, Kiril Ahtarovski, Stig Haunsø, Lars Køber, Erik Jørgensen, Frants Pedersen, Jacob Tfelt-Hansen, Thomas Engstrøm
Journal: Journal of the American College of Cardiology (2015)
Capsule retention in a giant Meckel’s diverticulum containing multiple enteroliths
Authors: N. Courcoutsakis, M. Pitiakoudis, K. Mimidis, S. Vradelis, E. Astrinakis, P. Prassopoulos
Journal: Endoscopy (2011)

A 58-year-old man presented to hospital with diffuse abdominal pain, melena, and iron-deficiency anemia. Gastroscopy and colonoscopy were unremarkable. Wireless capsule endoscopy (WCE) (PillCam SB2; Given Imaging, Yoqneam, Israel) was then carried out. The video sequence showed the capsule passing through a narrow orifice of the distal ileum into a cavity containing multiple enteroliths swirling in a greenish fluid with debris ([Figs. 1] and [2]). Small ulcers were also demonstrated near the orifice in the bowel lumen. The capsule remained within the cavity until the battery was exhausted.
AB0560 Expression of Regulatory Factors Related to Reverse Cholesterol Transport in Patients with Systemic Lupus Erythematosus
Authors: T.K. Tso, W.-N. Huang, J.-L. Chen
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is the autoimmune disease that patients with chronic inflammatory phenomena can induce early atherosclerosis, thereby increasing the risk of cardiovascular disease. <h3>Objectives</h3> The aim of this study was to investigate the peroxisome proliferator-activated receptor γ (PPAR γ)- liver X receptors α (LXRα)-ATP binding cassette transporter-A1 (ABCA1) pathway in reverse cholesterol transport and its association with cholesterol removal factors including lecithin cholesterol acyltransferase (LCAT), cholesteryl ester transfer protein (CETP) and ABCA1. <h3>Methods</h3> A total of 68 subjects including thirty-eight SLE patients and thirty healthy subjects participated in this study. PPARα, PPARγ, LXRα and ABCA1 mRNA levels in peripheral blood mononuclear cells were analyzed by RT-PCR analysis and plasma levels of LCAT, CETP and ABCA1 were determined by enzyme-linked immunosorbent assay. <h3>Results</h3> PPARα, PPARγ, LXRα, and ABCA1 mRNA levels of SLE patients were significantly lower than those in healthy controls. With respect to insulin resistance, patients with HOMA IR&gt;2 had higher levels of glucose, insulin, and triglyceride (TG) than patients with HOMA IR&lt;2. However, HOMA-IR values were not related to factors involved in cholesterol efflux in this study. In addition, total cholesterol (TC) levels were significantly correlated to CETP and LCAT. Plasma TG levels were significantly correlated to CETP, and high-density lipoprotein cholesterol (HDL-C) levels were significantly correlated to PPARα, CETP, and LCAT in patients with SLE. The PPARγ mRNA expression was much more associated with HDL-C than TC and TG. The plasma levels of lipids in SLE seemed to be more associated with PPARα, PPARγ, LXRα and ABCA1 mRNA expressions than plasma level of ABCA1. <h3>Conclusions</h3> PPARα, PPARγ, LXRα and ABCA1 mRNA expressions were significantly decreased in SLE patients, suggesting the reduction of the reverse cholesterol transport in terms of PPARγ-LXRα-ABCA1 pathway may at least in part play an important role in the risk of atherosclerosis in SLE. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4141
Positron Emission Tomographic–Computed Tomographic Imaging of a Uterine Sarcoma
Authors: Subhash Cher, Eser Lay Ergun
Journal: Clinical Nuclear Medicine (2003)

From the Department of Radiology,* Children’s Hospital of Michigan, Detroit Medical Center, Wayne State University School of Medicine, Detroit, Michigan; and the Department of Nuclear Medicine,† Hacettepe University Medical Faculty, Ankara, Turkey Received for publication July 8, 2002. Accepted October 18, 2002. Correspondence: Subhash Chander, Children’s Hospital of Michigan/PET Center, 3901 Beaubien, Detroit, Michigan 48201. E-mail: [email protected]
Panel Wants Less Exposure to Ultraviolet Radiation
Authors: P. Chemaly
Journal: JNCI Journal of the National Cancer Institute (1989)

Panel Wants Less Exposure to Ultraviolet Radiation Get access Philippe Chemaly, Jr. Philippe Chemaly, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 12, 21 June 1989, Page 897, https://doi.org/10.1093/jnci/81.12.897 Published: 21 June 1989
Drainage trans-bulbaire avec pose de prothèse par voie échoendoscopique des sténoses biliaires: résultats à long terme d'une série prospective
Authors: E Ben Soussan, C Pauphilet, JF Lefebvre, B Mader, D Bonnel
Journal: Endoscopy (2014)

Plusieurs études ont rapportées l'intérêt potentiel d'un abord trans-hépatique ou trans-bulbaire écho-endoscopique chez des patients ictériques en rapport avec une sténose biliaire maligne, après échec de la CPRE. Cette étude a évalué de façon prospective la faisabilité et la morbidité à court et long terme de la pose d'une prothèse biliaire métallique par voie écho-endoscopique et trans-bulbaire chez des patients ictériques, après échec du drainage endoscopique rétrograde.
Colonic Adenocarcinoma Metastatic to Bone With Gross Heterotopic Bone Formation
Authors: STEPHEN L. STUCKEY
Journal: Clinical Nuclear Medicine (1996)

A 72-year-old woman had increasing swelling and pain in the right thigh. Her medical history included a resected colonic carcinoma and, 4 months before the current admission, a fractured shaft of the right femur. Biopsy of the right thigh mass revealed metastatic adenocarcinoma, consistent with colonic origin, with metaplastic bone formation. Tc-99m MDP uptake in bone forming metastatic colonic adenocarcinoma may be much more intense than normal bone and beyond the confines of the usual bone anatomical boundaries, mimicking other pathologies such as myositis ossificans and osteosarcoma.
Sequential endoscopic drainage and clip closure of an intrathoracic esophagogastric anastomotic dehiscence
Authors: Samuel Costa, Carlos Ferreira, Rui Esteves, Patrícia Lages, Paulo Costa, Luís Ribeiro, José Velosa
Journal: Endoscopy (2014)

A 69-year-old man underwent an upper gastrointestinal endoscopy, which revealed a large submucosal lesion in the distal esophagus with normal overlying mucosa. Endoscopic ultrasound (EUS) showed a hypoechoic lesion measuring 80 × 40 × 30 mm in the submucosa ([Fig. 1]). A subtotal esophagectomy was performed. Histopathological examination of the resected tissue revealed a duplication cyst.
Effect of Restricting Dietary Protein on the Progression of Renal Failure in Patients with Insulin-Dependent Diabetes Mellitus
Authors: Kathleen Zeller, Elaine Whittaker, Lynn Sullivan, Philip Raskin, Harry R. Jacobson
Journal: New England Journal of Medicine (1991)

Restriction of dietary protein may slow the progression of renal failure in diverse renal diseases, but the extent to which such a diet is beneficial in patients with diabetic nephropathy is uncertain.
P61 Pulmonary nontuberculous mycobacterial (NTM) culture is common following lung transplantation, and NTM lung disease is associated with poor prognosis
Authors: T. T. Gorsuch, I. Crossingham, M. Cullen, M. Al-Aloul
Journal: Thorax (2010)

<h3>Introduction</h3> NTM lung disease (NTMLD) is commonly associated with advanced pre-existing lung disease or defective cellular immunity. Lung transplant (LTx) recipients receive potent immunosuppression and often have structural lung abnormalities, so might be at uniquely high risk of NTM infection and disease. However, there is little published about NTM following LTx. <h3>Method</h3> We carried out a retrospective study of NTM in LTx recipients attending our centre between 1/1/2005 and 31/8/2009. NTMLD was diagnosed according to American Thoracic Society (ATS) guidelines. <h3>Results</h3> 326 respiratory samples (from 172 LTx recipients) were sent for mycobacterial culture, of which 51 samples (15.6%) from 39 patients (22.6%) grew NTM. Samples from 32 patients (82%) grew <i>M avium</i> complex (MAC), three grew <i>M abscessus</i>, two <i>M gordonae</i>, one <i>M kansasii</i> and one <i>M malmoense</i>. Nine patients had multiple positive cultures (maximum four), but only one species was ever isolated from each individual. None had NTM preoperatively, although one had a single isolate of NTM before the study period. 23 patients had positive culture from BAL or multiple sputum samples, and 21 patients had chest radiology compatible with NTM. ATS radiological and microbiological criteria were met in 13 patients (33%). Those diagnosed with NTMLD according to ATS guidelines had a significantly higher death rate than those from whom no NTM were isolated (HR 2.42, 95% CI 1.09 to 5.37), whereas those who did not meet ATS criteria did not. Four patients were treated for NTM: one was cured, while two deteriorated and died. The fourth developed renal impairment and treatment was abandoned; symptoms and lung function improved. <h3>Comment</h3> In our cohort, respiratory NTM were cultured more frequently than previously reported, but a smaller proportion met ATS criteria for NTMLD and fewer were treated than in a previous cohort (15.6%, 33% and 10% respectively, compared with 6.5%, 73% and 82%). MAC is consistently the most common isolate. Patients with NTMLD by ATS criteria do worse than those without. Our data suggest that LTx is likely to be a risk factor for NTM infection but the majority of isolates represent colonisation/contamination. We advocate following ATS guidelines for treatment decisions of NTMLD after LTx.
Abstract 1227: Modulation of EGF-receptors signaling by small peptidomimetic molecules in breast cancer cells
Authors: Sashikanth Banappagari, Seetharama Satyanarayanajois, Miriam Corti, Seth Pincus
Journal: Cancer Research (2012)

Abstract Protein-protein interactions play a crucial role in regulating many biological processes as well as in disease pathology. Understanding the structural basis and modulating protein-protein interactions has a tremendous impact in developing new therapeutic strategies for many human diseases. Human epidermal growth factor receptor family of proteins (EGFR, HER2, 3 and 4) plays an important role in cell growth and proliferation. Aberrant interactions of EGFR family of proteins lead to tumor growth and metastasis. HER2, a member of EGFR family of proteins is overexpressed in approximately 25% of breast cancers. Deregulation of HER2 signaling pathways and overexpression of HER2 is known to occur in many cancers. HER2 is known to form heterodimers and is a major therapeutic target in breast cancer treatment. Formation of HER2 receptor heterodimerization with other EGFR family of proteins such as EGFR, HER3 is essential for intracellular kinase activation and is the basis for exploring direct inhibition of EGFR activation by blocking dimerization for therapeutic purposes. We have designed several small peptidomimetics to inhibit HER2-mediated signaling for cell growth. One of such peptidomimetics, Compound 5 (Arg-[3-amino-naphthyl-propionic acid]-Phe) designed, exhibited antiproliferative activity with IC50 values in the nM range against HER2 overexpressing breast cancer cell lines, SKBR-3 and BT-474. Binding studies using Florescence Microscopy, ELISA, Circular Dichroism (CD) and Surface Plasmon Resonance (SPR) confirmed that compound 5 binds specifically to HER2-extracellular domain. SPR studies revealed that compound 5 specifically binds to domain IV of HER2 extracellular region. Also, Compound 5 inhibited HER2-HER3 as well as HER2-EGFR heterodimerization evaluated by SPR. Pathhunter and proximity ligation assays confirmed the inhibition of HER2 heterodimerization with EGFR and HER3 by compound 5. Western blots revealed that compound 5 blocks the transphosphorylation of HER2 protein. Based on these observations small peptidomimetic inhibitor molecules can be potential therapeutic agents in disabling HER2 mediated heterodimerization. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1227. doi:1538-7445.AM2012-1227