tbuckley/cabot-search huggingface dataset:
OC-040 First in-vivo study on the use of lectin-based molecular imaging in barrett’s oesophagus
Authors: M Di Pietro, E Bird-Lieberman, T Nuckcheddy-Grant, I Debiram, P Safranek, RC Fitzgerald
Journal: Gut (2015)

<h3>Introduction</h3> The current standard for Barrett’s oesophagus (BO) endoscopic surveillance is based on random quadrantic biopsies every 2 cm. This is limited by sampling error due to inconspicuous dysplasia. We have previously found that an edible lectin (wheat germ agglutinin or WGA) has lower affinity for dysplastic compared to non-dysplastic BO and in an <i>ex vivo</i>model of molecular imaging we showed that WGA-fluorescein in combination with autofluorescence imaging (AFI) can target dysplasia in BO (Bird-Lieberman, Nat Med, 2012). In this study we used a pre-operative setting to investigate <i>in vivo</i>WGA-based molecular imaging <h3>Method</h3> Inclusion criteria were: <i>i</i>. MDT referral to oesophagectomy for oesophageal adenocarcinoma (OAC) and <i>ii.</i>evidence of endoscopically visible BO associated to OAC on index endoscopy or staging endoscopic ultrasound. In the operating theatre prior to oesophagectomy, the oesophagus was first inspected by white light imaging to locate the tumour and measure the size of the associated BO. Imaging was then switched to AFI to locate AFI positive areas (red-purple colour). Up to two AFI negative areas (green colour) were also selected for control biopsy sampling. 20–30 mL of 5 µg/mL WGA-fluorescein were then sprayed onto the mucosal surface. After 5 min, the mucosa was gently washed with water and the oesophagus was inspected again in AFI mode. On WGA-enhanced AFI, areas of high WGA binding were located (WGA positive, green colour), as well as areas of low binding (WGA negative, red-purple and hence high risk). Targeted biopsies were taken for histopathological correlation. Histological outcome was binarised based on the presence or absence of dysplasia. Chi-squared test was used to compare diagnostic accuracy for dysplasia of AFI alone and WGA-enhanced AFI <h3>Results</h3> 16 patients were recruited at a single centre, of which 12 completed the protocol. 4 patients were excluded due to absence of visible BO associated with the OAC at the time of resection. Across the 12 patients a total of 41 endoscopic locations were selected for biopsy of which 29 were WGA negative and 12 were WGA positive. The overall sensitivity for dysplasia of AFI alone was 78% and the specificity was 50%. When compared to AFI alone, WGA improved sensitivity from 78% to 88%, with a slight increase in the specificity to 56%. AFI and WGA-enhanced AFI had an equal false positive rate (24%). No toxicity events where recorded. <h3>Conclusion</h3> WGA-based molecular imaging is safe and feasible <i>in vivo</i>. The use of WGA may improve the sensitivity of AFI for dysplasia, but larger studies in a surveillance population are required <h3>Disclosure of interest</h3> None Declared.
Combined use of molindone and guanethidine in patients with schizophrenia and hypertension
Authors: L L Simpson
Journal: American Journal of Psychiatry (1979)

Human sympathetic nerves have a high-affinity norepinephrine uptake system. This uptake system is inhibited competitively by chlorpromazine but not by molindone, which suggests that molindone will not interact adversely with guanethidine, an antihypertensive drug that enters sympathetic nerves via the high-affinity uptake system. Accordingly, patients with concomitant schizophrenia and hypertension were treated simultaneously with molindone and guanethidine; there was no evidence of an adverse drug interaction. The data indicate that molindone and guanethidine can be used in combination safely and effectively.
FRI0112 Dermatologic Adverse Events in a Cohort of Patients with Rheumatoid Arthritis Using Biological Therapy in a Real-Life Setting
Authors: F. Salas, G. Fuquen, J. Castro, G. Saavedra, D. Gomez, J. Bello-Gualtero, P. Santos-Moreno
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Biological therapy is a major therapeutic tool to prevent clinical and radiological progression of rheumatoid arthritis (RA). On the other hand, adverse effects of these medications are a problem in clinical practice. <h3>Objectives</h3> The aim of this study was to describe and compare the most frequent dermatologic adverse events with the use of biologic therapy in patients with RA in a real-life ambulatory setting. <h3>Methods</h3> A descriptive study was done. A review of dermatological adverse event reports presented in pharmacovigilance committee was completed monthly during last 45 months in a specialized in RA center in Colombia. Descriptive epidemiology was used, percentages and averages were calculated. <h3>Results</h3> 680 patients were using biological therapy in a cohort of 2905 RA patients last 45 months; 579 women (85.2%) and 101 (14.8%) men. Mean age 60.3 years old. In 153 (22.5% of all patients who received biologics) patients were reported dermatologic adverse events (AE); AE were categorized according WHO classification in mild, moderate and severe; between them 53 (34.6%) were mild, 88 (57.5%) were moderate and 12 (7.8%) were severe. From 153 events reported, only 3 (1.9%) needed a biopsy to clarify what type of dermatologic reaction presented. Regarding therapeutic approach in 54 patients (35.2%) biologics were temporally suspended, in 21 (13.7%) was permanently withdrawn, 27 patients (17.6%) were switched to another biological, and 51 (33.3%) patients were followed for drug and reactions surveillance. From 153 events reported, 11 (7.1%) were acute dermatitis, 51 (33.3%) were dermatologic symptoms due to allergic skin rashes, 20 (13.1%) infection by Herpes zoster, 24 (15.6%) were dermatologic symptoms due to infection causes and the other 47 cases (30.7%) were due to other causes. Concerning to type of biologic, in 124 patients (81.0%) dermatologic adverse events were with anti-TNF therapies. <h3>Conclusions</h3> Dermatological adverse events using biologics are observed in a fifth of patients from a specialized RA center and are similar to those reported in literature; Biological therapy is considered a safe and recommended treatment for management of RA. Dermatologic AE were more mostly common with anti-TNFs subcutaneous therapies. <h3>Disclosure of Interest</h3> None declared
On the generalizability of the Chunk-and-Pass processing approach: Perspectives from language acquisition and music
Authors: Usha Lakshmanan, Robert E Graham
Journal: Behavioral and Brain Sciences (2016)

Abstract Christiansen &amp; Chater (C&amp;C) offer the Chunk-and-Pass strategy as a language processing approach allowing humans to make sense of incoming language in the face of cognitive and perceptual constraints. We propose that the Chunk-and-Pass strategy is not adequate to extend universally across languages (accounting for typologically diverse languages), nor is it sufficient to generalize to other auditory modalities such as music.
FRI0270 Tocilizumab Compared to Anti-TNFα Agents in Refractory Aortitis
Authors: N. Palmou-Fontana, J. Loricera, R. Blanco, J.L. Hernández, S. Castañeda, N. Ortego, E. Peirό, P. Collado, S. Melchor, A. Mera, E. Pérez-Pampín, E. Rubio, J. Calvo-Alén, E. Aurrecoechea, Í. Rúa-Figueroa, M. Mínguez, G. Herrero-Beaumont, B. Bravo, J. Rosas, J. Narváez, J. Calvo-Catalá, R. Ariza, M. Freire, P. Lluch, C. Mata, E. Galíndez-Aguirregoikoa, J.M. Blanco-Madrigal, A. Sánchez-Andrade, J. Salvatierra, V. Calvo-Río, C. González-Vela, T. Pina, M.A. González-Gay
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Aortitis is often refractory to conventional immunosuppressive (IS) therapy. The use of biological therapy, such as tocilizumab (TCZ) and anti-TNFα agents, had been reported. <h3>Objectives</h3> Our aim was to compare the efficacy of TCZ with anti-TNFα therapy in patients with aortitis. <h3>Methods</h3> Retrospective multicenter study of patients with aortitis refractory to traditional IS agents. <h3>Results</h3> We studied 44 patients (36 W/8 M; 51±19 years); 25 with TCZ and 19 with anti-TNFα agents (IFX=14, ADA=3, and ETN=2). Baseline features of patients on TCZ compared to the antiTNFα group (always in this order) showed a) mean age: 58±20 vs 42±13 years (p=0.003), b) women: 84% vs 79%, (p=0.97), c) underlying conditions: Takayasu arteritis, 8 vs 11 cases (p=0.08); giant cell arteritis, 15 vs 2 (p=0.0025); relapsing polychondritis, 1 vs 1 (p=0.59); ulcerative colitis, 0 vs 1 (p=0.88); Crohn9s disease, 0 vs 1 (p=0.88); Behçet9s disease, 0 vs 1 (p=0.88); sarcoidosis, 0 vs 1 (p=0.88); psoriatic arthritis, 0 vs 1 (p=0.88); and idiopathic aortitis, 1 vs 0 (p=0.88) d) mean of previous traditional IS agents (1.1 vs 1.7, p=0.069) and biological therapies (0.3 vs 0.1, p=0.23). After 3 months of treatment, most patients in both groups had experienced a clinical and acute phase reactants improvement, as well as a reduction of the corticosteroid dose. This favorable response was maintained over time (Table). The improvement observed by imaging techniques was similar in both groups. After a median follow-up of 12 [9-17] vs 16 [12-36] months (p=0.014), TCZ was withdrawn due to severe neutropenia (n=1); recurrent pneumonia (n=1); cytomegalovirus infection (n=1) and systemic lupus erythematosus (n=1). Other adverse effects were thrombocytopenia (n=1) and infusional hypotension (n=1). One patient died due to a stroke in the setting of an infective endocarditis, and another one discontinued TCZ because of inefficacy. In the anti-TNFα group, 3 patients on IFX discontinued due to inefficacy (n=1), recurrent pneumonia (n=1) and severe infusional reaction (n=1). <h3>Conclusions</h3> Biological therapy appears effective and relatively safe in patients with aortitis refractory to traditional IS drugs. In this series, TCZ seems to be slightly more effective than antiTNFα agents. <h3>Disclosure of Interest</h3> None declared
Ergo Sum?
Authors: Samuel Vaisrub
Journal: JAMA (1974)

A cartoon that appeared in the<i>New Yorker</i>(circa 1958) depicts a man reading a computer printout to his friend. "I'll be damned: It says `Cogito, ergo sum.' " Pursuing the same theme, a cartoon in<i>World</i>(June 5, 1973) shows a computer triumphantly exclaiming "I think; therefore, I am." Apparently, 15 years have failed to allay the suspicion that the automated brain may someday—if it had not already done so—arrive at the cartesian formula that would put it on par with the human. True, we are told that the computer is merely an electronic automaton doing what it is programmed to do. Still, when confronted with an entity that plays chess, composes poetry, translates prose, regulates traffic, tells jokes, interprets electrocardiograms, makes diagnoses, and prescribes treatment, can we escape the uncomfortable notion that we are facing or may soon face a<i>res cogitans</i>and<i>ergo</i>a something that is a
A Hybrid SOM-SVM Approach for the Zebrafish Gene Expression Analysis
Authors: Wei Wu, Xin Liu, Min Xu, Jin-Rong Peng, Rudy Setiono
Journal: Genomics Proteomics & Bioinformatics (2005)

Microarray technology can be employed to quantitatively measure the expression of thousands of genes in a single experiment. It has become one of the main tools for global gene expression analysis in molecular biology research in recent years. The large amount of expression data generated by this technology makes the study of certain complex biological problems possible, and machine learning methods are expected to play a crucial role in the analysis process. In this paper, we present our results from integrating the self-organizing map (SOM) and the support vector machine (SVM) for the analysis of the various functions of zebrafish genes based on their expression. The most distinctive characteristic of our zebrafish gene expression is that the number of samples of different classes is imbalanced. We discuss how SOM can be used as a data-filtering tool to improve the classification performance of the SVM on this data set.
von Hippel–Lindau Disease
Authors: D J Goldsmith, P Thomas
Journal: New England Journal of Medicine (1999)

Figure 1. Evaluation of a 35-year-old man with recent headache and unsteadiness and a history of blindness of the left eye for two years revealed normal blood pressure and renal function, a hemoglobin concentration of 18.2 g per deciliter, and a hematocrit of 0.59. T2-weighted magnetic resonance imaging (MRI) of the brain showed a cerebellar tumor (arrow in Panel A), which was found at surgery to be a benign hemangioblastoma. After the tumor was removed, his hemoglobin concentration fell to 14.5 g per deciliter. Ocular examination showed retinal hemangioblastomas, which were treated with laser ablation and led to . . .
Abstract 2655: Determinants of sensitivity to PI3K inhibitors in PIK3CA wildtype gastric tumor cells
Authors: Mei Ling Chong, Bhaskar Bhattacharya, Dominic Voon, King Xin Koh, Hong Hui Low, Ti Ling Chang, Mengchu Wu, Patrick Boon Ooi Tan, Marie Chiew Shia Loh, Touati Benoukraf, Huynh The Hung, Oliver Politz, Ningshu Liu, Richie Chuan Teck Soong
Journal: Cancer Research (2015)

Abstract Background: PIK3CA mutations are emerging as useful indicators of sensitivity to PI3K inhibitors, However many PIK3CA wildtype cells are also sensitive to PI3K inhibitors, and a biomarker of these cells is desirable This study aimed to identify and functionally verify determinants of sensitivity to PI3K inhibitors in PIK3CA wildtype cells. Materials and Methods: Eight PIK3CA wildtype gastric cancer cell lines were screened by MTS assay for their sensitivity to 6 PI3K inhibitors (BAY 806946 (Copanlisib), BAY 1082439, GDC-0941, BKM120, BYL719, XL147). Categorization of cells was performed by unsupervised clustering of quantile normalized IC50 values. RNA sequencing was performed using the ScriptSeqv2 mRNA-Seq kit, Illumina HiSeq 2000, and Partek software. Functional evaluation was performed by lentivirus modulation and standard phenotypic analyses. Six patient-derived PIK3CA wildtype gastric tumor xenograft models (PDXs) were also evaluated for sensitivity to PI3K inhibition and candidate expression. Results: Unsupervised clustering revealed two subgroups, comprising 3 resistant and 5 sensitive cell lines. Among differentially expressed genes, IGFBP3 had the highest overexpression (67-fold) in sensitive cells. IGFBP3 encodes insulin growth factor binding protein 3, which sequesters insulin growth factor (IGF) from binding to its receptor (IGF-1R). The sequestration of IGF by IGFBP3 may repress alternative activation of PI3K pathways through IGF signaling. Consistent with this, overexpression of IGFBP3 increased cell sensitivity to PI3K inhibitors and was accompanied by reduced IGF-1R, Akt and S6 phosphorylation and increased G1 arrest. IGFBP3 expression was also significantly higher in PDXs responsive to PI3K inhibitors than in those resistant. Conclusions: High IGFBP3 may be a useful biomarker of sensitivity to PI3K inhibitors in PIK3CA wildtype gastric tumor cells. Citation Format: Mei Ling Chong, Bhaskar Bhattacharya, Dominic Voon, King Xin Koh, Hong Hui Low, Ti Ling Chang, Mengchu Wu, Patrick Boon Ooi Tan, Marie Chiew Shia Loh, Touati Benoukraf, Huynh The Hung, Oliver Politz, Ningshu Liu, Richie Chuan Teck Soong. Determinants of sensitivity to PI3K inhibitors in PIK3CA wildtype gastric tumor cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2655. doi:10.1158/1538-7445.AM2015-2655
<sup>18</sup>F-DPA-714 PET Imaging for Detecting Neuroinflammation in Rats with Chronic Hepatic Encephalopathy
Authors: Xiang Kong, Song Luo, Jin Rong Wu, Shawn Wu, Carlo N. De Cecco, U. Joseph Schoepf, Adam J. Spandorfer, Chun Yan Wang, Ying Tian, Hui Juan Chen, Guang Ming Lu, Gui Fen Yang, Long Jiang Zhang
Journal: Theranostics (2016)

Neuroinflammation is considered to be the pathogenesis of hepatic encephalopathy (HE), and imaging neuroinflammation is implicated in HE management. 11C-PK11195, a typical translocator protein (TSPO) radiotracer, is used for imaging neuroinflammation.However, it has inherent limitations, such as short half-life and limited availability.The purpose of this study was to demonstrate the efficiency of new generation TSPO radiotracer, 18 F-DPA-714, in detecting and monitoring neuroinflammation of chronic HE.This study was divided into two parts.The first part compared 18 F-DPA-714 and 11 C-PK11195 radiotracers in ten HE induced rats [bile duct ligation (BDL) and fed hyperammonemic diet (HD)] and 6 control rats.The animal subjects underwent dynamic positron emission tomography (PET) during 2-day intervals.The 11 C-PK11195 PET study showed no differences in whole brain average percent injected dose per gram (%ID/g) values at all time points (all P>0.05), while the 18 F-DPA-714 PET study showed higher whole brain average %ID/g values in HE rats compared to control group rats at 900 s to 3300 s after injecting radiotracer (all P<0.05).The second part of the study evaluated the effectiveness of ibuprofen (IBU) treatment to chronic HE.Forty rats were classified into six groups, including Sham+normal saline (NS), Sham+IBU, BDL+NS, BDL+HD+NS, BDL+IBU, and BDL+HD+IBU groups. 18F-DPA-714 PET was used to image neuroinflammation.Whole and regional brain average %ID/g values, neurological features, inflammatory factors and activated microglia showed better in the IBU groups than in the NS groups (all P<0.05) and no difference was seen in the Sham groups compared to IBU groups (all P>0.05).In conclusion, this study demonstrated that 18 F-DPA-714 is an ideal TPSO radiotracer for imaging neuroinflammation and monitoring anti-neuroinflammation treatment efficacy of chronic HE.
Atypical tardive dyskinesia
Authors: R A Moline
Journal: American Journal of Psychiatry (1975)

The author reports an atypical case of tardive dyskinesia in a 19-year-old male who had been given relatively low dosages of neuroleptic medication for less than 6 months. The symptoms cleared within 3 months after the medication was discontinued. The author reviews the literature regarding similar atypical cases and suggests that increased reporting and careful description of such cases might be useful in furthering our understanding of this syndrome.
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1958)

COMMITTEE ON MATERNAL WELFARERheumatic Heart Disease, with Twin Pregnancy, Pulmonary Infection and Heart FailureA thirty-two-year-old gravida 4, para 3, had been followed since the age of fifteen for recurrent rheumatoid arthritis, which was noted during each of three previous pregnancies but which remained asymptomatic during them without special care. Post partum she had had several attacks of joint pain and swelling, each subsiding with bed rest and salicylates.The patient weighed over 90.7 kg. (200 pounds), and dyspnea developed in the first month of pregnancy, for which she spent ten days in the hospital, being treated with digitalis, . . .
Second bone marrow transplantation in non-Hodgkin's lymphoma.
Authors: A Messori, M Costantini, L Bonistalli, R Alterini
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.2.804 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9469378 Second bone marrow transplantation in non-Hodgkin's lymphoma. A MessorixA MessoriSearch for articles by this author , M CostantinixM CostantiniSearch for articles by this author , L BonistallixL BonistalliSearch for articles by this author , R AlterinixR AlteriniSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.2.804 First Page PDF © 1998 by American Society of Clinical Oncology
Salmonella enteric infections in Gipuzkoa, Spain, 1983-2000
Authors: J. M Marimon, E Pérez-Trallero, M. Gomariz, C. Rodríguez-Andres, C. López-Lopategui
Journal: Eurosurveillance (2003)

The incidence of Salmonella enteric infections in Gipuzkoa, Spain, was estimated by studying a stable population between 1983 and 2000. Only stool culture confirmed cases were included. The annual mean rate of infection in children under 2 years old was 1121 per 100,000 (CI 95%; 1060-1181). This age group had the highest relative risk (RR), 16.2-fold higher than the RR of those aged over 14 years. Salmonella Enteritidis was the most prevalent serovar (80.4% of all patients), followed by Salmonella Typhimurium (11.7%).
Sentinel Node Mapping in Melanoma of the Back
Authors: Valerio Duce, Gianpiero Manca, Sara Mazzarri, Fulvio Lorenzetti, Patrick M Colletti, Domenico Rubello, Duccio Volterrani
Journal: Clinical Nuclear Medicine (2015)

A 32-year-old man with melanoma on the right paramedian region of the lower back underwent lymphoscintigraphy for radioguided sentinel node (SN) biopsy. Planar imaging showed the presence of 2 sites of radioactivity accumulation corresponding to an axillary SN and to an "in-transit" SN, located on the right side of the upper trunk. A further "hot spot" placed on the left paramedian region of the lower back was identified by planar lymphoscintigraphy. This last finding could be mistaken for another "in-transit" SN, but SPECT/CT demonstrated it was actually a nonspecific radiopharmaceutical accumulation at the level of the right renal pelvis.
Case 19-1966
Authors: David Littmann, Benjamin Castleman
Journal: New England Journal of Medicine (1966)

Presentation of Case First admission. A fifty-eight-year-old man was admitted to the hospital because of dyspnea.At the age of twenty-five years he had had acute rheumatic fever accompanied by heart block, with a fall in the pulse rate to 40. He remained in bed for several months and recovered uneventfully. A film of the chest taken seventeen years before admission was normal (Fig. 1). No subsequent cardiac examination was recorded until four years before admission, when atrial fibrillation developed and reverted spontaneously; an aortic diastolic murmur was heard at that time. Atrial fibrillation recurred two years later, and . . .