tbuckley/cabot-search huggingface dataset:
SAT0520 Neuropsychiatric Involvement in Juvenile-Onset Systemic Lupus Erythematosus Patients: Relation to Disease Characteristics
Authors: T.A. Gheita, S. Sayed, M. Eissa, I.S. Bilal, A.M. Nour El Din, S.A. Kenawy
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile Onset Systemic Lupus Erythematosus (JO-SLE) is a chronic and multisystemic autoimmune disease, which appears before 16 years old and a variable clinical spectrum. Neuropsychiatric involvement in Juvenile SLE results in significant morbidity and mortality. <h3>Objectives</h3> To assess Neuropsychiatric manifestations of SLE (NPSLE) in JO-SLE patients and study the predictors and relation to disease characteristics <h3>Methods</h3> 112 Juvenile onset SLE patients were included in the study; 36 with NPSLE and 76 without. Disease activity and damage were assessed using the Systemic lupus erythematosus disease activity index (SLEDAI) and Systemic Lupus International Collaborating Clinics/Damage Index (SLICC/ACR DI) respectively. Detailed neurological examination was performed and manifestations reported for those with NPSLE. <h3>Results</h3> Neuropsychiatric manifestations of the SLE patients included lupus cerebritis and hallucinations (n=32), psychosis (n=8), seizures (n=8), stroke and weakness (n=5), peripheral neuritis (n=7), Headache (n=4), cognitive impairment (n=3), transverse myelitis (2) and depression (1). The age, disease duration and BMI were significantly increased in those with NPSLE (p=0.009, p=0.014 and p=0.011 respectively). They were associated with more frequent lupus nephritis (p=0.015) however the renal biopsy classes were comparable. The SLEDAI and SLICC tended to be higher in those with NPSLE (p=0.15 and p=0.06 respectively). Twenty-one patients were children with Juvenile SLE (12.81±2.28 years) while 91 were adult SLE cases with juvenile onset (23.18±3.87 years). There was no significant difference in the frequency of NPSLE among both age groups (p=0.21) though higher in the adults with JO-SLE. None of the studied variables would significantly predict NPSLE however, only the BMI tended to. <h3>Conclusions</h3> Pediatric rheumatologists should be aware of the frequency of neuropsychiatric disturbances in Juvenile-onset SLE children as adults. The neuropsychiatric disorders do not always correlate with disease activity or damage but should be looked for in cases with overt lupus nephritis. <h3>Disclosure of Interest</h3> None declared
Self-assembling peptide for co-delivery of HIV-1 CD8+ T cells epitope and Toll-like receptor 7/8 agonists R848 to induce maturation of monocyte derived dendritic cell and augment polyfunctional cytotoxic T lymphocyte (CTL) response
Authors: Yong Ding, Jun Liu, Sheng Lu, Justice Igweze, Wen Xu, Da Kuang, Chris Zealey, Daheng Liu, Alex Gregor, Ardalan Bozorgzad, Lei Zhang, Elizabeth Yue, Shariq Mujib, Mario Ostrowski, P. Chen
Journal: Journal of Controlled Release (2016)
The Rodger Winn Award
Journal: Journal of the National Comprehensive Cancer Network (2015)

Over the past 20 years, staff at NCCN have had the pleasure of working with many thoughtful and dedicated oncologists and other health care professionals, as well as patient advocates and patients themselves.Perhaps one of the most memorable was Rodger Winn, MD.As was noted in last month's NCCN Anniversary Reflections, Dr. Winn was both the "father" of the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) and the founding Editor-in-Chief of JNCCN.He was an enthusiastic advocate for patients, fellow health care providers, and NCCN itself, and he continued working to further the mission of improving the lives of patients with cancer, even through his own cancer diagnosis and treatment, until his death in 2007.To celebrate his life and dedication, each year NCCN gives The Rodger Winn Award to one NCCN Guidelines Panel Member who exemplifies Dr. Winn's leadership, drive, and commitment to the development of evidence-based guidelines tempered by expert judgment.The recipient provides a voice for the core mission of NCCN, improving the quality of care for patients.Specifically, the award recognizes service in the development of clinical practice guidelines, promotion of collegiality in NCCN activities, commitment to excellence, and dedication to multidisciplinary care.To help mark the 20th Anniversary of the organization that Dr. Winn helped begin, JNCCN asked some of the past recipients of the Rodger Winn Award to talk about the role of NCCN:
SAT0015 Increased Concentrations of CCL5, PDF-AA and PDGF-BB are Associated with Irreversible Vascular Remodeling of the Pulmonary Circulation in Interstitial Lung Disease Associated Pulmonary Arterial Hypertension
Authors: R. Huynh, R. Saggar, N. Li, R. Elashoff, E. Volkmann, R. Saggar, A. Derhovanessian, D. Ross, M. Fishbein, J. Lynch, Y. Palchevskiy, S. Weigt, J. Belperio
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> While pulmonary arterial hypertension complicating ILD (PAH-ILD) is associated with markedly increased mortality, PAH directed therapy has not been adequately studied in this population. We previously demonstrated that PAH directed therapy with intravenous or subcutaneous prostacyclin (PGI<sub>2</sub>) in patients with PAH-ILD improves right heart haemodynamics (1). However, it remains unclear which patients with PAH-ILD will respond to therapy. <h3>Objectives</h3> The present study seeks to investigate whether specific chemokines and growth factors, previously found to be associated with vascular remodeling, can be used to predict PAH directed therapy responsiveness. We hypothesized that PAH-ILD patients with augmented levels of specific CC chemokines (CCL2 and CCL5), as well as downstream growth factors (EGF, FGF-2, PDGF-AA and PGF-BB), may exhibit decreased responsiveness to PAH-directed therapy in ILD. <h3>Methods</h3> In this single-center study, plasma samples (n=15) were collected prospectively prior to initiation of PGI<sub>2</sub> therapy. Plasma concentrations of CCL2, CCL5, EGF, FGF-2, PDGF-AA and PDGF-BB were evaluated by fluorochrome (Luminex) technology. Response to PGI<sub>2</sub> was assessed as a reduction in PVR from right heart catherization at 12 months. A Kendall9s tau (τ) rank correlation coefficient was used to measure the association between baseline concentrations of specific chemokines and growth factors and PGI<sub>2</sub> response. <h3>Results</h3> In our cohort of 15 patients with ILD (8 idiopathic pulmonary fibrosis, 3 combined pulmonary fibrosis/emphysema, 2 non-specific interstitial pneumonia, 1 sarcoid, and 1 hypersensitivity pneumonitis) and PAH (baseline mean pulmonary artery pressure of 47.2 mmHg and pulmonary vascular resistance of 697.9 dyn s/cm<sup>5</sup>), higher concentrations of the CC chemokine CCL5 (τ =0.49, p=0.0138), as well as the growth factors PDGF-AA (τ =0.47, p=0.0186) (See Figure 1), and PDGF-BB (τ =0.49, p=0.0138) were negatively correlated with a relative change in PVR in response to PGI<sub>2</sub> therapy. <h3>Conclusions</h3> Elevated baseline concentrations of plasma chemokine CCL5 and growth factors PDGF-AA and PDGF-BB affecting vascular fibroproliferation may be associated with irreversible remodeling of the pulmonary circulation in response to PGI<sub>2</sub> therapy in ILD associated PAH. <h3>References</h3> Saggar R et al. Thorax 2014; 69:123-129. <h3>Disclosure of Interest</h3> None declared
GREATER GROWTH IN MONGOLOIDS
Authors: H P AIDEM, L D BAKER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
THE PROGRESS OF PREVENTIVE MEDICINE
Authors: G CHAREST
Journal: JAMA (1918)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ureteral Hernia Mimicking Retrocrural Lymphadenopathy in 18F-FDG PET/CT
Authors: Lanamar Almeida, Felipe Carvalhaes, Almir Bitencourt, Fernando Moreira
Journal: Clinical Nuclear Medicine (2015)

An 82-year-old woman was submitted to 18F-FDG PET/CT to evaluate an indeterminate solitary lung nodule identified on chest CT. At the examination, there was a hypermetabolic area at the topography of the right retrocrural region, mimicking a lymphadenopathy on axial images. After careful analysis of multiplanar CT images, it was better characterized as a loop of the ureter insinuating itself by a small diaphragmatic hernia. Ureteral hernia is a rare entity with few cases reported in the literature. This case demonstrates the importance of conducting careful evaluation of multiplanar CT images to avoid false-positive results on PET/CT.
RESISTANCE TO ANTIBIOTICS
Authors: Jesús Silva Sánchez
Journal: JAMA (1968)

Bacterial resistance to antibiotics is a major public health problem around the world causing high rates of morbi-mortality and economic problems in hospital settings. Major bacterial causing nosocomial infections are: extended-spectrum beta-lactameses (ESBL) producing enterobacteria, methicillin resistance Staphylococcus aureus, coagulase negative Staphylococcus, metallo fl-lactamases (MBL) producing Pseudomonas aeruginosa, Streptococcus pneumoniae, Enterococcus spp, Acinetobacter baumani. This last bacteria is not very often isolated in hospital settings yet, but it is multi-resistance pathogen causing high mortality. Helicobacter pylori, which is not a nosocomial pathogen but is associated to gastric diseases (from gastritis to gastric cancer). Infections prevention, to obtain an accuracy diagnostic and effective treatment, use antibiotic wisely and pathogen dissemination prevention (hand washing), are important steps to control the bacterial resistance.
OC-051 Practicalities of setting up a new procedure room in endoscopy
Authors: N Taggart, J Batterton, D McGuinness, L Flavell, N Haslam, S Sarkar
Journal: Gut (2015)

<h3>Introduction</h3> A fifth endoscopy room was set up at the Royal Liverpool Hospital (RLH) October 2014; this was necessary to guarantee an increased capacity in order to meet current and predicted service needs. This was to accommodate the increase in activity from upper and lower GI investigation including the Be Clear on Cancer campaign, the bowel cancer screening programme (BCSP) and rise in complex endoscopy. <h3>Method</h3> <b>Aim</b>: This is a reflective look at a room set up. What was achieved by its set up and what lessons have been learned through the process. <b>Prior to implementation</b>: 4 rooms were undertaking 17,500 procedures per year with 25% inpatients 75% day-case activity. Waiting times were urgent 2 wks, routine 6 weeks, and surveillance 6 weeks. Due to the rise in referrals extra lists were being planned at weekends in order to maintain current targets. The cost of the waiting lists for the year was £400,000.00 running 200 lists in 2014. Staff often worked during the week and the weekend which impacted negatively on work life balance. <b>Resource planning </b>10 extra sessions were created. A sound business case was needed to support the £375,000.00 investment. A stack system was purchased. Extra scopes purchased to support increased lists. Consideration made regarding purchase of extra stock and consumables. Further storage areas needed to be found to house equipment. Close links developed with estates teams and architects. <b>Workforce planning and implementation. </b>A collaborative approach between Trust, Consultants, Nurse Managers, Administration and Human Resources and nursing unions was necessary to ensure full staff engagement as job plans and contracts had to be altered. The increased workload required a long term investment of; 1 X WTE Nurse Endoscopist (for training and 6 lists), 5X WTE Nurses/6 WTE HCAs,1 X WTE Admin. Consultant endoscopists opt in to extra sessions. <b>Operational issues: </b>Space in recovery is premium staff now discharge all un-sedated patients directly from procedure room. New roles established, band four staff to assist in discharging. Assessment of environmental limitations, considerations need to be made on single sex pathways. <h3>Results</h3> All routine and 2ww targets have been maintained. No WLI sessions to date. Complex therapy lists have increased by two/three sessions per week. Able to facilitate an extra two lists for colonoscopy per week. Work-force flexibility and a steady communication with admin manager has meant 95% utilisation for all sessions. <h3>Conclusion</h3> An extra endoscopy room improves capacity and reduces waiting times but needs workforce planning and significant capital investment. Environmental constraints will need careful consideration. Creating a new room requires planning, leadership, workforce flexibility and a dedicated team. <h3>Disclosure of interest</h3> None Declared.
Organ-to-Cell-Scale Health Assessment Using Geographical Information System Approaches with Multibeam Scanning Electron Microscopy
Authors: Melissa L. Knothe Tate, Dirk Zeidler, André F. Pereira, Daniel Hageman, Tomasz Garbowski, Sanjay Mishra, Lauren Gardner, Ulf R. Knothe
Journal: Advanced Healthcare Materials (2016)

This study combines novel multibeam electron microscopy with a geographical information system approach to create a first, seamless, navigable anatomic map of the human hip and its cellular inhabitants. Using spatial information acquired by localizing relevant map landmarks (e.g. cells, blood vessels), network modeling will enable disease epidemiology studies in populations of cells inhabiting tissues and organs.
Some Biochemical Differences in Normal and Tumor Tissue (Sarcoma 180) of Mice: Amino Acid Composition<xref ref-type="fn" rid="fn1">2</xref>
Authors: M. N. Mickelson, Louis Barvick
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Some Biochemical Differences in Normal and Tumor Tissue (Sarcoma 180) of Mice: Amino Acid Composition Get access M. N. Mickelson, M. N. Mickelson Chemistry Division, Midwest Research Institute, Kansas City, Missouri Search for other works by this author on: Oxford Academic PubMed Google Scholar Louis Barvick Louis Barvick Chemistry Division, Midwest Research Institute, Kansas City, Missouri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 1, July 1956, Pages 65–75, https://doi.org/10.1093/jnci/17.1.65 Published: 01 July 1956 Article history Received: 29 March 1955 Published: 01 July 1956
Corticosteroids for Bacterial Meningitis
Authors: Catherine W Ong, Li Yang Hsu, Paul A Tambyah
Journal: New England Journal of Medicine (2008)

Corticosteroids for Bacterial MeningitisTo the Editor: Mai et al. (Dec.13 issue) report that dexamethasone improved survival among patients with definite bacterial meningitis. 1 However, dexamethasone was associated with decreased survival in the group of patients with probable meningitis, which was hypothesized to be due to delayed antituberculosis treatment in patients with presumed tuberculous meningitis.Since it is recommended that corticosteroids be given before or at the time of the initial dose of antibiotics, 2 do the authors recommend that only patients with positive Gram's staining of cerebrospinal fluid receive corticosteroids?Should this restriction be applied only to countries with a high incidence of tuberculous meningitis?How long was the delay in antituberculosis therapy after dexamethasone treatment for the eight patients with presumed tuberculous meningitis in the group of patients with probable meningitis?In the nine patients with confirmed tuberculous meningitis in the alternative-diagnosis group, four patients received dexamethasone and five patients received placebo, and yet there was a trend toward increased mortality among those who received dexamethasone.In light of the authors' previous findings on the benefits of dexamethasone in patients with tuberculous meningitis, 3 was there a delay in the receipt of antituberculosis drugs in the four patients with confirmed tuberculous meningitis who received dexamethasone?If so, what was the difference in the delay in administering antituberculosis drugs between the eight patients with presumed tuberculous meningitis and the four patients with confirmed tuberculous meningitis who received dexamethasone?
Peer review and PSRO: an update
Authors: F W Sullivan
Journal: American Journal of Psychiatry (1976)

The author provides a summary of developments in peer review and Professional Standards Review Organizations (PSROs) within APA, the federal government, and the American Medical Association between June 1974 and June 1975. He discusses the reaction of the medical profession to the interim guidelines from the U.S. Department of Health, Education, and Welfare and the problems of financing PSROs. He concludes that the key issues for PSROs and peer review in general are the availability and effectiveness of local review components, and that lack of involvement on the part of psychiatry will only ensure that nonpsychiatrists will design the review procedures.
AB1095 Adverse Events from Diagnostic Arthrocentesis for Suspicion of Gout: A Systematic Analysis in a Large Multi-Centre Cohort
Authors: W.J. Taylor, J. Fransen, N. Dalbeth, T. Neogi, H.R. Schumacher, T. Jansen
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Arthrocentesis is a common procedure in rheumatology clinical practice, usually to obtain synovial fluid for diagnostic purposes or as a therapeutic procedure for glucocorticoid intra-articular injection. There is a generally held belief amongst rheumatologists that needle arthrocentesis is a safe and well-tolerated procedure. Previous reports of the safety of needle arthrocentesis have been in the context of glucocorticoid injection (1). The safety of diagnostic arthrocentesis has not been previously studied systematically. <h3>Objectives</h3> To determine the frequency of adverse events of diagnostic arthrocentesis in patients suspected to have gout. <h3>Methods</h3> Consecutive patients with recent joint swelling or possible tophus underwent arthrocentesis or nodule tissue aspiration as part of a cross-sectional diagnostic study for gout. All patients were evaluated at 6 weeks by telephone or in the clinic to determine any adverse events (AE) following the arthrocentesis. The 95% confidence intervals for the percentage frequency of AE were obtained by bootstrapping. <h3>Results</h3> Arthrocentesis was performed in 910 patients and 887 of these patients (97.5%) were evaluated for AE. Any adverse event was observed in 12 participants (1.4%, 95%CI 0.6 to 2.1). The commonest AE was pain (5 events), nearly all of which were rated as mild. Other non-serious AE reported were bruising (2 events), and joint swelling (4 events). There was 1 case (0.1%, 95% CI 0 to 0.34) of septic arthritis subsequent to the arthrocentesis who required hospitalization and antibiotics. <h3>Conclusions</h3> Diagnostic arthrocentesis is safe and associated with a very low frequency of adverse events, which are generally mild. However, septic arthritis rarely occurs with an estimated (bootstrapped 95% CI) frequency of between 0 and 3.4 per 1000 patient-procedures. <h3>Acknowledgements</h3> This study was supported by the American College of Rheumatology, European League against Rheumatism, Arthritis New Zealand, Association Rhumatisme et Travail, and Asociaciόn de Reumatόlogos del Hospital de Cruces. <h3>Disclosure of Interest</h3> None declared
Response to Letter Regarding Article, “Air Versus Oxygen in ST-Segment–Elevation Myocardial Infarction”
Authors: Dion Stub, Karen Smith, Stephen Bernard, Ziad Nehme, Michael Stephenson, Janet E. Bray, Peter Cameron, Bill Barger, Andris H. Ellims, Andrew J. Taylor, Ian T. Meredith, David M. Kaye
Journal: Circulation (2016)
Case 26-1981
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Frederick S. Southwick, Daniel Lew, David L. Gang
Journal: New England Journal of Medicine (1981)

Presentation of Case First admission. A 12-month-old boy was admitted to the hospital because of a cervical mass.He was born of an uncomplicated first full-term gestation and a normal delivery. At 2 1/2 months of age otitis media developed and resulted in perforation of the tympanic membrane. During the next few months he had recurrent bouts of otitis media, which ceased after the prophylactic institution of sulfisoxazole; one month before admission sulfisoxazole was discontinued.He was otherwise well until one week before entry, when his parents noticed the abrupt onset of a swelling in the left posterior cervical . . .