tbuckley/cabot-search huggingface dataset:
Abstract 5530: Fluorescence laparoscopy improves metastatic detection in both early and advanced colon cancer
Authors: Rhiana Menen, Sharmeela Kaushal, Cynthia Snyder, Robert M. Hoffman, Michael Bouvet
Journal: Cancer Research (2012)

Abstract The aim of the present study was to improve detection and treatment of colon cancer with the use of fluorescence laparoscopy in an orthotopic mouse model of human colon cancer. The orthotopic model was established by intra-cecal injection of GFP-expressing HCT-116 human colon cancer cells into 12 six-week-old female athymic mice. Two models were then established: one of early disease and the second of widely metastatic disease. Two weeks after implantation, 6 mice underwent diagnostic laparoscopy. Laparoscopy was performed first under standard brightfield lighting, followed by fluorescent lighting. The number of metastatic foci identified within each of the four quadrants of the peritoneal cavity was recorded in three mice in each light mode. This process was repeated in the second group 4 weeks after implantation. Following laparoscopy, all animals were sacrificed. Fluorescence imaging was used as a positive control to identify metastasis at necropsy. Tumors and metastases were collected and processed for histologic review. Fluorescence laparoscopy enabled visualization of colon cancer metastatic foci which could not be visualized with standard brightfield laparoscopy in both the early (p= 0.028) and late (p= 0.001) models of colon cancer. When compared to the positive control of open fluorescence imaging, standard brightfield laparoscopy was significantly inferior in both the early (p= 0.03) and late (p= 0.0005) groups. Conversely, fluorescence laparoscopy was not significantly different from open fluorescence imaging in either the early (p= 0.94) or late (p= 0.56) groups. Fluorescence laparoscopy thus allowed identification and localization of sub-millimeter micrometastases that could not be distinguished from surrounding tissue under brightfield laparoscopy. Metastatic lesions were histologically confirmed. This report illustrates the important clinical potential of fluorescence laparoscopy in the surgical treatment of cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5530. doi:1538-7445.AM2012-5530
FRI0576-HPR Static and dynamic postural control in individuals with chondromalacia patellae
Authors: A. P. M. C. Carvalho E Silva, G. Leão, M. Magalhães, A. P. Marques
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Chondromalacia patellae is a common cause of anterior Knee pain, especially in young athletes or sedentary [1]. These individuals often have muscle weakness of the quadriceps and gluteus medius, responsible for controlling the posterior and lateral balance, respectively [2]. The pain and muscle weakness could alter postural control, mainly in functional activities [3]. <h3>Objectives</h3> To assess static and dynamic postural control in individual with and without patellae chondromalacia. <h3>Methods</h3> This study examined 40 women divided in two groups: Chondromalacia patellae(CP), n= 20, mean age 26 (6.6), weight 60.9 (10.2), height 162 (7) cm and Control Group (CG), n=20, mean age 24 (4.1), weight 58.4(6.0) Kg, height 163(5) cm. Postural control was evaluated in a force platform <i>NeuroCom Balance Master</i>. Static postural control was assessed by the one-leg support in two situations: eyes open (EO) and eyes closed (EC), while the dynamic control was assessed by the sit-to-stand test. We evaluated the symptomatic limb for chondromalacia patellae group and the dominant limb for the control group. The variables analyzed were: Time to transfer the center of gravity (COG), COG Sway Velocity and Rising Index. Pain was assessed with a visual analog scale (VAS) and function by the scale of activities of daily living (ADLS). Intergroup statistical analysis was performed using the <i>t test</i> and <i>Mann- Whitney</i> for data with normal and without normal distribution respectively. A significance level was α=0.05<b>.</b> <h3>Results</h3> The chondromalacia patellae group presented worse postural control, static and dynamic, with faster COG sway velocity in one-leg support in both situations (OE and CE) and for sit-to-stand test (p&lt;0.05). The CP group shows moderate pain, 5.7 (1.6) and minimal functional disability, 70.4 (7.5). <h3>Conclusions</h3> Individuals with chondromalacia patellae have greater sway in support of COG one-leg support with EO and EC and in sit-to-stand activity rising, suggesting a deficit in postural control static and dynamic relative to the control group. <h3>References</h3> Casscells SW. Chondromalacia of the patella. J Pediatr Orthop 1982;2:560–4. Magalhães E, Fukuda TY, Sacramento SN, Forgas A, Cohen M, Abdalla RJ. A comparison of hip strength between sedentary females with and without patellofemoral pain syndrome. J Orthop Sports Phys Ther. 2010;40:641-7. Lee SP, Souza RB, Powers CM. The influence of hip abductor muscle performance on dynamic postural stability in females with patellofemoral pain. Gait Posture. 2012 Jul;36:425-9. <h3>Disclosure of Interest</h3> None Declared
A Comparison of Clozapine and Haloperidol in Hospitalized Patients with Refractory Schizophrenia
Authors: Robert Rosenheck, Joyce Cramer, Weichun Xu, Jonathan Thomas, William Henderson, Linda Frisman, Carol Fye, Dennis Charney
Journal: New England Journal of Medicine (1997)

Clozapine, a relatively expensive antipsychotic drug, is widely used to treat patients with refractory schizophrenia. It has a low incidence of extrapyramidal side effects but may cause agranulocytosis. There have been no long-term assessments of its effect on symptoms, social functioning, and the use and cost of health care.
Reflux Disease and Barrett's Esophagus
Authors: H Koop
Journal: Endoscopy (2000)

Gastroesophageal reflux disease (GERD) is still an important clinical problem. Continuing efforts are being made to establish a classification of the condition that would allow improved communications for both clinical and research purposes. In medical treatment, the trends are toward proton-pump inhibitor therapy at all stages of GERD, calling into question the role of endoscopy for tailoring individual therapy. Arguments against the use of H. pylori eradication therapy in GERD have gained importance. Surgeons are continuing to report excellent results with fundoplication, but careful studies are needed to prove whether antireflux surgery is really capable of saving costs, as its proponents claim.
Peux t'on considérer qu'un patient est guéri quand de l'adénocarcinome est présent sur une pièce d'ampullectomie endoscopique?
Authors: I Oria, O Luna, C Lefort, G Rodica, JY Scoazec, F Fumex, R Bourdariat, V Lépilliez, AI Lemaistre, B Napoleon
Journal: Endoscopy (2015)

Selon la classification TNM des tumeurs ampullaires, un adénocarcinome pT1 est limité à l'ampoule de Vater sans infiltration de la musculeuse duodénale. Le risque de métastases ganglionnaires (N+) est chiffré autour de 20% dans les séries chirurgicales occidentales. La classification japonaise subdivise les lésions pT1 en tumeurs d0, limitées au sphincter d'Oddi (risque de N+= 0%) et en tumeurs d1 envahissant la sous-muqueuse duodénale (risque de N+= 30%). Les chirurgiens japonais considèrent une lésion d0 sans embol vasculaire comme un cancer précoce pouvant être traité curativement par un geste local. Aucune série endoscopique n'a pour le moment évalué si l'ampullectomie endoscopique (AE) était réellement curative dans cette situation.
Treatment of Mumps Orchitis with ACTH and Cortisone
Authors: Ian Maclean Smith, John W. Bishir
Journal: New England Journal of Medicine (1958)

THE most disabling and striking complication of mumps is orchitis, which has been reported as affecting 15 to 40 per cent1 , 2 of adult males in different epidemics. The pain appears to be related to acute distention of the testicle within the rigid tunica albuginea, and relief can be obtained by surgical incision of this capsule. Because cortisone and ACTH are well known for their anti-inflammatory action they have been tried by a number of investigators in the hope that they might be as effective as surgery.Most reports of adrenal-hormone treatment for mumps orchitis discuss a few personally treated cases. . . .
Functional Evidence of CFTR Gene Transfer in Nasal Epithelium of Cystic Fibrosis Mice in Vivo Following Luminal Application of DNA Complexes Targeted to the Serpin-Enzyme Complex Receptor
Authors: Assem-Galal Ziady, Thomas J. Kelley, Erin Milliken, Thomas Ferkol, Pamela B. Davis
Journal: Molecular Therapy (2002)

Molecular conjugates that target the serpin-enzyme complex receptor transfer the cDNA encoding human cystic fibrosis transmembrane conductance regulator (CFTR) to the nasal epithelium of cystic fibrosis mutant mice. These complexes effect partial correction of the chloride transport defect as assessed by <i>in vivo</i> nasal potential difference measurements, produce immunohistochemical staining for CFTR, and restore expression of nitric oxide synthase-2 (NOS-2), which is downregulated in the epithelium of mice and humans with cystic fibrosis. Complexes that lack the receptor ligands were ineffective, so receptor access was essential. Mice treated with receptor-targeted <i>lacZ</i> showed β-galactosidase expression in epithelial cells and submucosal glands, but no electrophysiologic correction or NOS-2 expression, so simply accessing the serpin-enzyme complex receptor was not sufficient to produce the observed electrophysiologic or immunohistochemical changes. Correction of the cAMP-stimulated chloride transport was dose related at days 7 and 12 after complex administration, but, for most animals, nasal potential difference had returned to baseline by day 18. Molecular conjugates targeting the serpin-enzyme complex receptor, used to compact plasmid DNA, hold promise for gene therapy of cystic fibrosis.
THE VALUE OF ADDITIONAL TESTING AFTER NON-DIAGNOSTIC STRESS ECHOCARDIOGRAPHY IN PATIENTS PRESENTING WITH CHEST PAIN: A SINGLE-CENTER ANALYSIS
Authors: Joseph Gibbs, Mouhamad Mansour, Sagger Mawri, Youssef Nasr, Daryl Sudasena, Karthikeyan Ananthasubramaniam
Journal: Journal of the American College of Cardiology (2016)
Vitamin E Consumption and the Risk of Coronary Heart Disease in Men
Authors: Eric B. Rimm, Meir J. Stampfer, Alberto Ascherio, Edward Giovannucci, Graham A. Colditz, Walter C. Willett
Journal: New England Journal of Medicine (1993)

The oxidative modification of low-density lipoproteins increases their incorporation into the arterial intima, an essential step in atherogenesis. Although dietary antioxidants, such as vitamin C, carotene, and vitamin E, have been hypothesized to prevent coronary heart disease, prospective epidemiologic data are sparse.
Abstract 2374: First time identification of circulating tumor cellsin murine models of human non-small cell lung cancer
Authors: Pierre Mordant, Yohann Loriot, Charles Decraene, Benoit Lahon, Yves Castier, Jean-Charles Soria, Eric Deutsch
Journal: Cancer Research (2011)

Abstract Background. Circulating tumor cells (CTCs) have been found in up to 40% of patients with either localized or metastatic non-small cell lung cancer (NSCLC). However, level of CTCs has never been established in preclinical murine models of human NSCLC. We sought to determine the levels of CTCs in subcutaneous and orthotopic murine models of human non-small cell lung cancer. Material and Methods. We used athymic nude mice and luciferase-positive A549 lung adenocarcinoma cell line (A549-luc, Xenogen Corp, USA). In group 1, animals underwent subcutaneous injection of cells in both flank (n=6). In group 2, animals underwent general anesthesia, chest wall incision, and transpleural injection of cells in the parenchyma of the left lung (n=15). After 2 weeks, bioluminescent in vivo imaging (IVIS) was performed after intra peritoneal injection of luciferine, and xenograft implantation rates were calculated. During the third week, tumor-bearing animals were anesthetized, 1-mL venous blood was punctured from the cavernous sinus, mixed with 7-mL of healthy human blood, and tested using the Cellsearch assay (Veridex LLC, USA). Animals were then humanely killed. Results. Xenograft implantation rates were 100% in group 1 (n=6) and 60% (n=9) in group 2. Among the 6 blood tubes collected from the first group, none were clotted, 6 tubes underwent successful Cellsearch assay, and 5 assays were positive for CTCs detection (CTCs level range 2-5, mean 2.5, sd 1.76). Among the 9 blood tubes collected from the second group, 3 tubes were clotted and impossible to analyze, 6 tubes underwent successful Cellsearch assay, and 5 assays were positive for CTCs detection (CTCs level range 2-21, mean 9.5, sd 9.35). When comparing groups, the difference in CTC levels show a trend toward statistical significance (student test, p=0.058). Conclusions. Two weeks after tumor implantation, CTCs are detected in 83% of nude mice bearing either subcutaneous or orthotopic NSCLC tumors. Evolution of CTCs level should be established, but this model could be of interest to study oncogenesis and to assess new treatments. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2374. doi:10.1158/1538-7445.AM2011-2374
Costs of Care and Administration at For-Profit and Other Hospitals in the United States
Authors: Steffie Woolhandler, David U. Himmelstein
Journal: New England Journal of Medicine (1997)

In fiscal year 1990, administration accounted for 24.8 percent of total hospital costs in the United States — nearly twice the share in Canada. Studies from the 1970s and early 1980s found high costs, especially for administration, at for-profit hospitals.
Stomach and Colorectal Cancers in Puerto Rican-Born Residents of New York City2
Authors: M. Ellen Warshauer, Debra T. Sliverman, David Schottenteld, Earl S. Pollack
Journal: JNCI Journal of the National Cancer Institute (1986)

Colorectal cancer incidence and mortality rates for Puerto Rican-born residents in New York City (PR-NYC) for 1975–79 were about two times those for Puerto Ricans living in Puerto Rico (PR-PR) and one-half to almost two-thirds those for other whites in New York City. From 1958 to 1979, colon cancer mortality rates for PR-NYC increased dramatically (i.e., 212% in males and 54% in females), whereas in PR-PR, male rates increased only slightly and female rates remained constant. For stomach cancer, incidence rates for male and female PR-NYC were slightly, but not significantly, higher than those for male and female PR-PR. In contrast, stomach cancer mortality rates for PR-NYC were lower than those for PR-PR throughout the survey period, and mortality decreased substantially in all racial-ethnic groups in New York City and Puerto Rico from 1958 to 1979. Results of this study indicated that the changes in colorectal and stomach cancer incidence and mortality in Puerto Rican-born residents after migration to New York City, although not as dramatic as in migrants from Japan and Eastern Europe, were comparable to those observed for Hispanic migrants to New Mexico and Los Angeles.
HEMODYNAMIC PERFORMANCE OF TRANSCATHETER HEART VALVES WITH SUPRA-ANNULAR OR INTRA-ANNULAR POSITION FOR TRANSCATHETER AORTIC VALVE-IN-VALVE IMPLANTATION
Authors: Miriam Silaschi, Olaf Wendler, Moritz Seiffert, Liesa Castro, Niklas Schofer, Anna Fink, Hermann Reichenspurner, Stefan Blankenberg, Philip MacCarthy, Ulrich Schaefer, Lenard Conradi
Journal: Journal of the American College of Cardiology (2016)
Tight Glycemic Control in Children — Is the Target in Sight?
Authors: Michael S.D. Agus
Journal: New England Journal of Medicine (2014)

Should a strategy of tight glycemic control with the use of intravenous insulin be used to normalize blood glucose concentration in critically ill children as part of their therapy? This approach significantly reduced morbidity, mortality, or both in two randomized, controlled trials involving children1,2 but not in a third, in which continuous glucose monitoring was performed.3 The patient populations differed among the three studies, with one involving children with severe burns, one involving children who were in the intensive-care unit (ICU) after cardiac surgery, and one involving children who were in the ICU for a variety of reasons. The . . .
Abstract 2066: Role of miR-182/miR-96 cluster in prostatic zinc homeostasis
Authors: Ekaterina A. Khramtsova, Avani Vaishnav, Nicoleta Arva, Angeline Antonio, Andre Kajdacsy-Balla, Larisa Nonn
Journal: Cancer Research (2010)

Abstract Zinc has been shown to have a defensive action against the development of prostate cancer (PCa). Zinc is an essential element that is required for the activity of more than 300 enzymes, structure of proteins, and control of genetic expression. It plays an important role in cellular processes such as cell division, growth, differentiation, development, aging, and synthesis and repair of DNA, RNA, and protein. Prostatic secretary epithelial cells accumulate large amounts of zinc and have a high expression of human Zinc transporter 1 (hZIP1), the major zinc transporter in the prostate. PCa tissue exhibits lower levels of zinc and hZIP1 compared with surrounding normal-appearing areas. Furthermore, compared to Caucasian men, the prostates of African American men, a population with a disproportionately high risk of developing PCa, have decreased zinc and hZIP1. Previously, we examined several miRNAs in formalin-fixed paraffin-embedded prostate tissue from African American and Caucasian patients, of which miR-182/96 levels were higher in PCa samples and had inverse correlation with hZIP1 mRNA in Caucasian patients (Spearman rho = −0.77, p=0.009). No correlation between hZIP1 and miR-182 was found in the African-American specimens, suggesting a different mechanism for hZIP1 regulation in African-Americans. Based on previous studies, we hypothesize that miR-182/96 cluster is responsible for regulation of hZIP1 levels in PCa and prostate tissue. In this study, we examined the relationship between the levels of miR-182/96 and hZIP1 in more detail using cell culture models. We observed an inverse correlation between hZIP1 and miR-182 levels in several prostate cell cultures; primary normal epithelial cells, normal stromal cells, and prostate cancer cells (PC3 and LNCaP). MiR-182 is transcribed in a cluster with miR-96 and the miRNAs have an overlapping mRNA target sequence. As expected, miR-96 expression was identical to that of miR-182, thus also inversely correlated with hZIP1 in prostate cell cultures. Overexpression of miR-182 in both normal and LNCaP cells decreased hZIP1 mRNA levels, further implicating miR-182 as a regulator of zinc transport. Ongoing experiments focus on validating the two putative miR-182/96 binding sites in the 3′UTR of hZIP1 and the effect of miR-182 and miR-96 overexpression on zinc transport. Our results may establish a role for miR-182 in prostatic zinc homeostasis. Because zinc levels are linked to PCa risk, these miRNAs may be useful as a prognostic or diagnostic marker in prostate biopsies to identify patients with high risk of PCa recurrence and for identifying individuals for zinc replacement. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2066.
Nov C-TER: A Novel VEGF-Independent Anti-Angiogenic Agent with a Promising Preclinical Anti-Tumor Efficacy
Authors: O. Rixe, X. Qi, Z. Chu, J. Celerier, L. Leconte, N. Minet, J. Pakradouni, B. Kaur, F. Cuttitta
Journal: Annals of Oncology (2013)
P434Functional MMP-10 is required for efficient tissue repair following experimental hindlimb ischemia
Authors: V Gomez-Rodriguez, J Orbe, JA Rodriguez, J Serneels, M Collantes, M Mazzone, JA Paramo, C Roncal
Journal: Cardiovascular Research (2014)

Purpose: Tissue ischemia triggers a bunch of cellular responses directed to restore blood flow and accelerate repair. Matrix metalloproteinases (MMPs), a family of zinc-dependent endopeptidases, contribute extensively to tissue remodeling in a variety of normal and disease processes, including ischemic disorders associated to vascular dysfunction (e.g.: peripheral artery disease, PAD). High gelatinolytic activity is necessary for tissue remodeling in response to arterial occlusion in experimental ischemia, however, the contribution of other MMPs, such as; collagenases, or stromelysins, has not yet been investigated. MMP-10 or stromelysin 2 has been suggested to be involved in disorders associated to tissue remodeling and inflammation, although it remains unknown its involvement in ischemic diseases. Methods: we used a model of femoral artery occlusion in wild type (WT) and MMP-10 deficient (Mmp10-/-) mice to study the role of MMP-10 in skeletal muscle repair. Results: At the degenerative phase, MMP-10 deficiency reduced tissue perfusion and increased necrosis and inflammation. At the regenerative phase, MMP-10 deficiency resulted in reduced tissue regeneration. The injection of recombinant human MMP-10 (rhMMP10) in Mmp10-/- mice rescued the observed phenotype. Compared to WT, ischemic Mmp10-/- muscles had higher levels of Cxcl1 (Gro-alpha), suggesting the involvement of chemokine production in muscle regeneration by MMP-10. Conclusions: Our results demonstrate an important role of MMP-10 for proper muscle repair during degenerative and regenerative phases of limb ischemia, and open new pathways for specific manipulation of MMP-10 in ischemic conditions.