tbuckley/cabot-search huggingface dataset:
FRI0626-HPR Higher Level of Psychological Distress, Pain and Tiredness Have a Negative Influence on Arthritis Patients' Well-Being: Table 1.
Authors: K. Grønning, O. Bratås
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The health status of patients with arthritis has consistently improved in later years (1), but research shows that depression still is a frequent comorbidity (2). It is also shown that patients9 self-efficacy may prevent future development of psychological problems (3), and that patients9 well-being is affected by disease-activity and coping skills (4). <h3>Objectives</h3> The aim of this study was to investigate the independent influence of disease-related and psychological factors on arthritis patients9 well-being by conducting secondary analyses on data collected in a randomized controlled trial (RCT) (5). The RCT studied the effect of nurse-led patient education (PE) in patients with arthritis. <h3>Methods</h3> The participants (N=132) were adult patients with arthritis from St. Olavs Hospital in Trondheim Norway. The present data were collected at 12 months follow-up, and consist of information on psychological distress, well-being, self-efficacy and disease-characteristics. A multivariable linear regression analyses was performed with well-being as dependent variable. Demographics, psychological distress, self-efficacy and disease-characteristics were independent variables. The analyses adjusted for participation in the PE program. <h3>Results</h3> The majority of our sample had RA, were women, with a mean age of 58 years. The analyses showed that more psychological distress, pain and tiredness had a negative independent influence on patients9 well-being when controlling for other variables. <h3>Conclusions</h3> This study found that higher psychological distress, more pain and tiredness were associated with lower well-being. Implications for clinical practice are that nurses continually need to focus on patients9 well-being and support patients with their daily management of disease symptoms. <h3>References</h3> Uhlig T, et al. Rheumatoid arthritis is milder in the new millennium: health status in patients with rheumatoid arthritis 1994-2004. Ann Rheum Dis 2008:67:1710-5. Matcham F, et al. The prevalence of depression in rheumatoid arthritis: a systematic review and meta-analysis. Rheumatology (Oxford) 2013:52: 2136-48. Garnefski N, et al. Effect of a cognitive behavioral self-help intervention on depression, anxiety, and coping self-efficacy in people with rheumatic disease. Arthritis Care Res (Hoboken) 2013:65:1077-84. Englbrecht M, et al. The interaction of physical function and emotional well-being in rheumatoid arthritis–what is the impact on disease activity and coping? Semin Arthritis Rheum 2013:42:482-91. Gronning K, et al. Long-term effects of a nurse-led group and individual patient education programme for patients with chronic inflammatory polyarthritis - a randomised controlled trial. J Clin Nurs, doi: 201310.1111/jocn.12353. <h3>Disclosure of Interest</h3> None declared
2009 pandemic influenza A(H1N1) outbreak in a complex of schools in Paris, France, June 2009
Authors: P Carrillo-Santisteve, S Renard-Dubois, G Cheron, M Csaszar-Goutchkoff, M Lecuit, O Lortholary, P Y Bello
Journal: Eurosurveillance (2010)

An outbreak of 2009 pandemic influenza A(H1N1), involving 81 cases with symptoms of influenza-like illness, was confirmed in June 2009 in a complex of schools in Paris, France. At that time, there was no community transmission in France. The index case, a 10-year-old girl, had travelled to the United Kingdom with her school class. Of the 81 symptomatic cases, 35 were confirmed and 46 were probable; 48 of the cases were female. Three were adults and 78 were children (median age of the children was 7.9 years, range: 6 months to 12 years). Control measures were implemented as soon as a new case was confirmed in a school, which included active case finding among the pupils in the same class as the index case, setting up a dedicated influenza outpatient clinic that families were recommended to consult if necessary, prophylactic treatment of contacts and school closure. A retrospective study was conducted on all confirmed cases and all symptomatic cases who had consulted the dedicated outpatient clinic from 17 to 27 June 2009. Further work is needed to better define conditions under which the pandemic virus can be transmitted in schools and in households.
No relation between risk of schizophrenia and prenatal exposure to influenza in Holland
Authors: E Susser, S P Lin, A S Brown, L H Lumey, L Erlenmeyer-Kimling
Journal: American Journal of Psychiatry (1994)

The authors compared the risk of schizophrenia in Dutch birth cohorts that were or were not exposed during the second trimester of gestation to the 1957 A2 influenza epidemic. Exposed birth cohorts did not have a higher risk of schizophrenia. These findings suggest that, in some populations, there is no relation between prenatal exposure to influenza and risk of schizophrenia.
2016 European guideline on the management of non-gonococcal urethritis published
Authors: Harald Moi, Paddy J Horner
Journal: Eurosurveillance (2016)

Preview this article: 2016 European guideline on the management of non-gonococcal urethritis published, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/21/22/eurosurv-21-22-5-1.gif
First-in-Class ROR1 Small Molecule Inhibitor (KAN0439834) Downregulated Wnt-Canonical and Non-Canonical Signaling Pathways and Induced Apoptosis of CLL Cells
Authors: Mohammad Hojjat-Farsangi, Ali Moshfegh, Amir Hossein Daneshmanesh, Jan Vågberg, Byström Styrbjörn, Johan Schultz, Elisabeth Olsson, Charlotta Löfberg, Carina Norström, Martin Norin, Thomas Olin, Anders Österborg, Håkan Mellstedt
Journal: Blood (2015)
Psychiatry residents in a milieu participatory democracy: a resident's view
Authors: D Gersten
Journal: American Journal of Psychiatry (1978)

Psychiatry residents respond with a variety of coping mechanisms to the lack of traditional structure in a milieu participatory democracy. To incorporate themselves into the system they must accept such democratic ideals as equality among staff and patients, group decision making, and free self-expression and give up some of their traditional ideas about staff and patient roles, treatment modalities, and the therapeutic environment. The author was a first-year resident in psychiatry on a university hospital inpatient therapeutic community; he discusses the conflicts between residents, who often adopt a "we-they" attitude, and the permanent staff, whose protectiveness of the ward community reflects their personal commitment to its ideals.
SP0194 Imaging as a Predictive Tool – Prognosis, Response and Relapse
Authors: C. van der Laken
Journal: Annals of the Rheumatic Diseases (2015)

The outcome of various rheumatic diseases clearly benefits from early, intensive and individualised treatment strategies. This requires sensitive tools that enable early diagnosis, disease activity monitoring and prediction of treatment outcome. There is increasing evidence that advanced imaging techniques may fulfil these clinical needs by non-invasive detection and (semi-)quantitative monitoring of disease activity, even at subclinical level. The spectrum of available and investigated imaging techniques in rheumatology has broadened over time, ranging from ultrasound, MRI to more recently explored techniques as PET(-CT/MRI) and optical imaging. Each technique has specific characteristics that can add clinical value. The focus of imaging studies is gradually changing from initial exploration of visualization of disease activity (changes) towards prospective studies focusing on investigation of imaging as predictive tool for prognosis of disease development, response and relapse to therapy. The lecture will provide an overview of the current status of advanced imaging techniques as predictive tools in rheumatology. <h3>Disclosure of Interest</h3> C. van der Laken Grant/research support from: Hoffmann La Roche, Pfizer, Abbvie
Microcephaly risk with Zika infection is 1-13% in first trimester, study shows
Authors: Michael McCarthy
Journal: BMJ (2016)

Maternal infection with the Zika virus in the first trimester of pregnancy was associated with an estimated 1% to 13% risk of microcephaly, researchers from the US Centers for Disease Control and Prevention have reported.1 Their study found “negligible” association between infection and the risk of microcephaly in the second and third trimesters.

The researchers analysed data from Bahia in northeastern Brazil, a region that has been hit hard by the Zika …
Effect of Carcinogenic Dosage and Duration of Exposure on Skin-Tumor Induction in Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Poel, William E.
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Effect of Carcinogenic Dosage and Duration of Exposure on Skin-Tumor Induction in Mice, Get access William E. Poel William E. Poel Laboratory for Experimental Carcinogenesis, Department of Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 22, Issue 1, January 1959, Pages 19–43, https://doi.org/10.1093/jnci/22.1.19 Published: 01 January 1959 Article history Received: 02 June 1958 Published: 01 January 1959
THU0192 Effect of Sulfasalazine on Decrease of Uveitis Flares in Patients with Ankylosing Spondylitis
Authors: A. Godzenko, A. Bochkova, O. Rumyantceva, I. Rasumova, V. Badokin, S. Erdes
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Relapsing uveitis is serious problem for patients with ankylosing spondylitis (AS). Anti-TNF therapy significantly reduces number of uveitis attacks in AS pts, but it is not always available. There is a need to assess influence of standard DMARDs on incidence of uveitis in AS pts. <h3>Objectives</h3> To compare rate of uveitis attacks during combined therapy using sulfaslazine and NSAIDs versus monotherapy by NSAIDs. <h3>Methods</h3> 111 pts with AS and uveitis were assessed at the Institute of Rheumathology. 49 used combined therapy by sulfaslazine 2 grams per day and NSAIDs at least 1 year, mean duration - 3,9±2,28 year. 6 of 49 pts had frequently relapsing course: more than 3 episodes of uveitis per year, 43 – not more, than 3. 62 pts used NSAIDs only during whole observation period, mean duration - 7,2±6,4 year, 9 of them had more than 3 episodes of uveitis per year, 53 – not more, than 3. 23 of 49 pts used NSAIDs only at least 1 year prior to combined therapy, 10 with more than 3 episodes of uveitis per year, 13 - not more, than 3. <h3>Results</h3> The mean rate of uveitis attacks during monotherapy by NSAIDs for whole group was 2,06±2,04 per year, during combined therapy – less, but not significantly: 1,41±1,83 per year, p=0,08. Among pts with frequency of attacks 3 and less mean rate during combined therapy was significantly lower, than during monotherapy: 0,99±0,87 and 1,37±0,91 accordingly, p=0,04. For pts with frequently relapsing course of uveitis mean rate of attacks was not significantly different: 5,5±2,7 using combined therapy and 5,7±2,5 using monotherapy, p=0,9. Among pts, used monotherapy and combined therapy sequentially, significant reducing of uveitis flares was observed in 13 pts, that had not more than 3 attack per year initially: from 1,92±0,96 to 0,4±0,44, p=0,00003. 10 pts with more than 3 attack per year initially had not significant reducing of uveitis flares: from 5,9±3,02 to 5,33±1,1, p=0,6. <h3>Conclusions</h3> Combined therapy by sulfaslazine and NSAIDs not reduces significantly number of uveitis attacks in AS pts with frequently relapsing course of uveitis, but significantly reduces among pts with mild disease. <h3>References</h3> Benitez-Del-Castillo JM, Garcia-Sanchez J, Iradier T, Bañares A. Sulfasalazine in the prevention of anterior uveitis associated with ankylosing spondylitis. Eye (Lond). 2000 Jun;14 (Pt 3A):340-3. Muñoz-Fernández S, Hidalgo V, Fernández-Melόn J. Sulfasalazine reduces the number of flares of acute anterior uveitis over a one-year period J Rheumatol. 2003 Jun;30(6):1277-957 <h3>Disclosure of Interest</h3> None declared
Mitomycin for treatment of brain parenchymal disease.
Authors: V Hug, G Hort
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.11.1787 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3183707 Mitomycin for treatment of brain parenchymal disease. V HugxV HugSearch for articles by this author , G HortxG HortSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.11.1787 PDF "Mitomycin for treatment of brain parenchymal disease.." Journal of Clinical Oncology, 6(11), p. 1787© 1988 by American Society of Clinical Oncology
PTU-314 Quality improvement project looking at inpatient acute gastrointestinal bleeds and ppi prescribing
Authors: M Samuel, C Thompson, J Emms, C Holt, D Higham
Journal: Gut (2015)

<h3>Introduction</h3> Inpatient acute upper gastrointestinal bleeds (AUGIB) are associated with a high mortality rate. The use of PPI therapy can reduce the incidence of these bleeds. We aimed to examine all inpatient AUGIB and observe the prescribing practices leading upto them. <h3>Method</h3> Data was collected on all patients that had an OGD following an inpatient AUGIB from January to June 2013. Mode of presentation, co morbidities, and medication on admission and post endoscopy were analysed. <h3>Results</h3> 91 inpatient AUGIB were identified. The median age was 68 of which 50 males and 41 females were identified. Mean length of time from admission to AUGIB was 12 days. The modes of presentation were malaena (60%), coffee ground vomit (35%) and anaemia (5%). Relevant co –morbidities include alcohol excess (45%), gastritis (23%), previous ulcer disease (22%) and IHD/ACS (10%). 21 AUGIB (23%) might have been prevented; 16% (15/21) had their PPI stopped whilst on antibiotics. Of the 15 patients who had their PPI stopped whilst on antibiotics 73% (11/15) were over the age of 75 and had multiple co morbidities. Furthermore 7% (6/21) which might have been prevented were on high dose dual antiplatelet therapy. 50% of them were over the age of 75 and not on a PPI. Post OGD all 21 patients who potentially may have been prevented from bleeding were commenced on a PPI. <h3>Conclusion</h3> 23% of inpatient AUGIB may have been prevented with adherence to appropriate prescribing practice and correct risk stratification. We have developed a new tool to assess AUGIB risk. <h3>Disclosure of interest</h3> None Declared.
Simultaneous Differential Staining of Phosphoproteins, Sialoglycoproteins, Hyaluronic Acid, Sulfated Glycosaminoglycans, Proteins, and Nucleic Acids in Human Breast Tissue With a Cationic Carbocyanine Dye
Authors: M R Green
Journal: JNCI Journal of the National Cancer Institute (1978)

Journal Article Simultaneous Differential Staining of Phosphoproteins, Sialoglycoproteins, Hyaluronic Acid, Sulfated Glycosaminoglycans, Proteins, and Nucleic Acids in Human Breast Tissue With a Cationic Carbocyanine Dye Get access Marie R. Green Marie R. Green Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 61, Issue 4, October 1978, Pages 1001–1009, https://doi.org/10.1093/jnci/61.4.951 Published: 01 October 1978 Article history Received: 03 January 1978 Accepted: 08 May 1978 Revision received: 16 August 1978 Published: 01 October 1978
PTU-058 Infliximab rescue therapy outcomes for steroid refractory acute severe ulcerative colitis: single centre experience
Authors: A O’Reilly, A Abiodun, MN Quraishi, R Boulton
Journal: Gut (2015)

<h3>Introduction</h3> Acute severe colitis affects up to 19% of patients with ulcerative colitis (UC) and around 30% of these patients are resistant to intensive steroid therapy and therefore require rescue therapy to prevent emergency colectomy. Although surgery is considered to be potentially curative, restorative proctocolectomy is generally associated with a poorer quality of life than those who respond to medical therapy and thus avoid surgery. UK guidelines recommend that infliximab is only considered as an option for the treatment of acute severe UC in patients in whom ciclosporin is inappropriate. This study evaluates the long term outcomes of UC patients receiving infliximab for rescue therapy at a single centre. <h3>Method</h3> We carried out a retrospective review of inpatients with steroid-refractory UC who were treated with infliximab as rescue therapy at University Hospital Birmingham between 2007 and 2014. Data collated included demographics, parameters including endoscopic assessment and operative details if applicable. IV steroid refractory UC patients who failed infliximab rescue therapy and underwent emergency colectomy were compared with those who were successfully rescued. Statistical analyses for categorical variables were assessed using a Fisher’s Exact Probability Test and continuous data were performed using a two-sample t-test assuming unequal variances. <h3>Results</h3> A total of 29 steroid refractory acute UC patients received infliximab rescue therapy with a mean follow up period was 2.5 years (range 1–7 years). 6 (21%) patients failed to respond to the rescue therapy and proceeded to emergency colectomy. Patients who underwent an emergency colectomy had a significantly lower albumin (mean 27 g/l vs 35 g/l; p &lt; 0.005), haemoglobin (93 g/l vs 120 g/l; p &lt; 0.005) and received IV steroids for a significantly longer period of time (mean 5 days vs 7 days; p &lt; 0.05). There was no difference in age, duration and extent of UC, endoscopic assessment of severity, WCC and CRP between the two groups. From those that were successfully rescued only 1 patient required a colectomy within 3 months and 3 patients after 1 year. Analysis of a further separate cohort of 7 UC patients who directly had infliximab as were refractory to oral steroids, demonstrated that none of them required an emergency colectomy, while 2 patients had a colectomy within 6 months and 1 patient after 1 year. <h3>Conclusion</h3> In patients with acute severe UC infliximab rescue therapy is effective in avoiding colectomy and maintaining remission however delaying its administration beyond 5 days of IV steroids is associated with a significantly higher risk of its failure and progression to emergency colectomy. <h3>Disclosure of interest</h3> None Declared.
Metabolic and Kidney Diseases in the Setting of Climate Change, Water Shortage, and Survival Factors
Authors: Richard J. Johnson, Peter Stenvinkel, Thomas Jensen, Miguel A. Lanaspa, Carlos Roncal, Zhilin Song, Lise Bankir, Laura G. Sánchez-Lozada
Journal: Journal of the American Society of Nephrology (2016)

Climate change (global warming) is leading to an increase in heat extremes and coupled with increasing water shortage, provides a perfect storm for a new era of environmental crises and potentially, new diseases. We use a comparative physiologic approach to show that one of the primary mechanisms by which animals protect themselves against water shortage is to increase fat mass as a means for providing metabolic water. Strong evidence suggests that certain hormones (vasopressin), foods (fructose), and metabolic products (uric acid) function as survival signals to help reduce water loss and store fat (which also provides a source of metabolic water). These mechanisms are intricately linked with each other and stimulated by dehydration and hyperosmolarity. Although these mechanisms were protective in the setting of low sugar and low salt intake in our past, today, the combination of diets high in fructose and salty foods, increasing temperatures, and decreasing available water places these survival signals in overdrive and may be accelerating the obesity and diabetes epidemics. The recent discovery of multiple epidemics of CKD occurring in agricultural workers in hot and humid environments may represent harbingers of the detrimental consequences of the combination of climate change and overactivation of survival pathways.
Abstract B26: Role of ribosomal protein, Rpl22 in regulating leukemic transformation.
Authors: Nehal Solanki Patel, Noa Greenberg, Suraj Peri, Shuyun Rao, Michele Rhodes, David Wiest
Journal: Clinical Cancer Research (2015)

Abstract Inactivation of ribosomal proteins (RP) is known to cause diseases called ribosomopathies, which are often associated with abnormal hematopoiesis and an increased risk for development of leukemia. Our laboratory has recently reported an important link between inactivation of one such ribosomal protein, Rpl22, and poor survival in T cell acute lymphoblastic leukemia (T-ALL) patients. Preliminary bioinformatic analysis shows that RPL22 is lost in ~10% of pediatric T-ALL patients, who exhibit a more aggressive disease course. Deletion of the RPL22 locus is also enriched in the early T-cell precursor (ETP-ALL) subset of T-ALL patients, which exhibit a more aggressive disease course. Thus, RPL22 loss appears to be a marker for poor outcome in pediatric T-ALL patients. While RP inactivation has previously been linked to increased cancer risk, the mechanistic basis for this linkage remained unclear. We have recently demonstrated that inactivation of Rpl22 promotes leukemic transformation by activating NF-kB and inducing the stem cell gene, LIN28B. Nevertheless, the molecular link between Rpl22 inactivation and the induction of NF-kB activity remained unclear. We have now determined that inactivation of Rpl22 activates NF-kB signaling by exacerbating ER stress responses. Indeed, Rpl22 loss results in hyperactivation of the PERK-EIF2α-ATF4 stress pathway, which is known to activate NF-kB. We have demonstrated that knockdown of PERK using shRNA abrogates the activation of NF-kB in Rpl22 mutant cells and returns Lin28B expression levels to baseline. This reduction in Lin28B eliminates the predisposition to transformation exhibited by Rpl22 mutant cells, as evidenced by decreased formation of colonies in soft agar. Taken together, these data suggest that RPL22 inactivation may serve as a negative prognostic indicator in T-ALL and that pharmacologic targeting of ER stress pathways may represent a novel therapeutic alternative in this molecularly-defined subclass of T-ALL. Citation Format: Nehal Solanki Patel, Noa Greenberg, Suraj Peri, Shuyun Rao, Michele Rhodes, David Wiest. Role of ribosomal protein, Rpl22 in regulating leukemic transformation. [abstract]. In: Proceedings of the AACR Special Conference on Hematologic Malignancies: Translating Discoveries to Novel Therapies; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(17 Suppl):Abstract nr B26.