tbuckley/cabot-search huggingface dataset:
Abstract 15722: Demographic Factors for 30 Day Readmission Following Percutaneous Coronary Intervention Procedure: Analysis of Nationwide Inpatient Sample Data
Authors: Sourabh Aggarwal, Vishal Gupta
Journal: Circulation (2014)

Introduction: Acute myocardial infarction is a major cause of morbidity and mortality in USA with percutaneous coronary intervention (PCI) as a mainstay of therapy. Short term hospital readmissions account for a significant portion of health care budget and much of the focus recently has been on reducing 30 day readmission rate. This study was done to determine demographic parameters associated with 30 day readmission rate after index PCI. Methods: Nationwide Inpatient Sample (NIS) data was used to extract data of patients discharged after PCI during index admission for years 2009-2011. Patients were identified by Clinical Classification Software code 45, corresponding to ICD 9 procedure codes of 00.66, 17.55, 36.01, 36.02 and 36.05. NIS represents 20% of all hospital data in US. Patients readmitted within 30 days were identified and demographic parameters associated with high readmission rate identified. Results: We identified a total of 1,784,929 hospitalizations where PCI was performed with 13.04% readmitted within 30 days after index hospitalizations. Elder age (65+), female gender, Medicaid insurance, low median income for zip code and metropolitan areas were associated with high 30 day readmission rate. Conclusions: This first national study identifies the demographic parameters associated with high 30 day readmission rate. Strategies to reduce morbidity and healthcare cost should be targeted more on these groups with high readmission rate. Study was limited by the fact that the admission for staged PCI could not he differentiated from unplanned readmission. Further studies might be needed to supplement the results.
Sudden Death in Infants Sleeping on Polystyrene-Filled Cushions
Authors: James S. Kemp, Bradley T. Thach
Journal: New England Journal of Medicine (1991)

Infants are at risk for both the sudden infant death syndrome (SIDS) and accidental suffocation. On postmortem examination, however, it is difficult to distinguish one from the other without information from the scene of death. Healthy infants are assumed to be able to turn their heads and, if not otherwise restrained, to obtain fresh air. We assessed this assumption in an investigation of infant deaths that occurred during sleep on cushions filled with polystyrene beads.
Risk Factors for the Onset of Eating Disorders in Adolescent Girls: Results of the McKnight Longitudinal Risk Factor Study
Journal: American Journal of Psychiatry (2003)

This study examined the importance of potential risk factors for eating disorder onset in a large multiethnic sample followed for up to 3 years, with assessment instruments validated for the target population and a structured clinical interview used to make diagnoses.Participants were 1,103 girls initially assessed in grades 6-9 in school districts in Arizona and California. Each year, students completed the McKnight Risk Factor Survey, had body height and weight measured, and underwent a structured clinical interview. The McKnight Risk Factor Survey, a self-report instrument developed for this age group, includes questions related to risk factors for eating disorders.During follow-up, 32 girls (2.9%) developed a partial- or full-syndrome eating disorder. At the Arizona site, there was a significant interaction between Hispanics and higher scores on a factor measuring thin body preoccupation and social pressure in predicting onset of eating disorders. An increase in negative life events also predicted onset of eating disorders in this sample. At the California site, only thin body preoccupation and social pressure predicted onset of eating disorders. A four-item screen derived from thin body preoccupation and social pressure had a sensitivity of 0.72, a specificity of 0.80, and an efficiency of 0.79.Thin body preoccupation and social pressure are important risk factors for the development of eating disorders in adolescents. Some Hispanic groups are at risk of developing eating disorders. Efforts to reduce peer, cultural, and other sources of thin body preoccupation may be necessary to prevent eating disorders.
Cell Proliferation In Mammary Epithelium and Correlated Histochemical Fluctuations in Mast Cells During the Estrous Cycle&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: D M Purnell, J W Combs, G C Saggers
Journal: JNCI Journal of the National Cancer Institute (1974)

The pattern of DNA synthesis and mitosis during the estrous cycle was studied In normal mammary epithelial cells (NME) of the LSH/SsLAK hamster to investigate whether mammary-associated mast cells (MAMC) responded to NME proliferation and, in turn, influenced NME proliferation. Hamsters at defined intervals from OVUlation were given injections of 3H-thymidine to measure DNA synthesis in NME and of colchicine to determine mitotic rate In NME. MAMC were examined by the alcian blue-safran In reaction. DNA synthesis of NME during the estrous cycle occurred as a single broad wave with a peak at 1–4 hours from ovulation (metestrus). In contrast, the mitotic rate of NME during the estrous cycle was biphasic with a first peak at 26 hours (middle diestrus) and a second at ≈ 86 hours (estrus). Cyclic histochemical changes observed in MAMC indicated release of heparin from these stromal cells during a portion of the estrous cycle. Temporal relationships between the cyclic mitotic activity of NME and histochemical changes in MAMC support the possibility that cyclic heparin release from MAMC reguates mitotic activity of NME. The findings are related to ovarian hormone fluctuations during the estrous cycle.
Afatinib versus gefitinib as first-line treatment of patients with EGFR mutation-positive non-small-cell lung cancer (LUX-Lung 7): a phase 2B, open-label, randomised controlled trial
Authors: Keunchil Park, Eng-Huat Tan, Ken O'Byrne, Li Zhang, Michael Boyer, Tony Mok, Vera Hirsh, James Chih-Hsin Yang, Ki Hyeong Lee, Shun Lu, Yuankai Shi, Sang-We Kim, Janessa Laskin, Dong-Wan Kim, Catherine Dubos Arvis, Karl Kölbeck, Scott A Laurie, Chun-Ming Tsai, Mehdi Shahidi, Miyoung Kim, Dan Massey, Victoria Zazulina, Luis Paz-Ares
Journal: The Lancet Oncology (2016)
Diagnosis and Staging of Colonic Tumors by Conventional Abdominal Sonography as Compared with Hydrocolonic Sonography
Authors: Bernd Limberg
Journal: New England Journal of Medicine (1992)

Ultrasonic examination has become increasingly important in the diagnosis of diseases of the gastrointestinal tract. In neoplastic diseases of the large intestine, however, the diagnostic value of conventional transabdominal sonography is limited. The purpose of this investigation was to determine whether the evaluation and staging of colonic tumors would be improved by the retrograde instillation of water into the colon in a procedure called hydrocolonic sonography.
The C159T Polymorphism of the CD-14 Gene in Adult Patients with Corticosteroid-Sensitive and Refractory Bronchial Asthma in Crimea, Ukraine
Authors: Yuri Bisyuk, Andrey I. Kurchenko, A.I. Dubovyi, Ganna V. Bisyuk, Lawrence M. DuBuske
Journal: Journal of Allergy and Clinical Immunology (2016)
Measurement of Residual Leukemia during Remission in Childhood Acute Lymphoblastic Leukemia
Authors: William Mark Roberts, Zeev Estrov, Maia V. Ouspenskaia, Dennis A. Johnston, Kenneth L. McClain, Theodore F. Zipf
Journal: New England Journal of Medicine (1997)

Complete remission of B-precursor acute lymphoblastic leukemia (ALL) has traditionally been defined as the near absence of lymphoblasts in a light-microscopical examination of stained bone marrow smears, but a patient in remission may still harbor up to 1010 leukemia cells. We investigated whether there is a relation between the outcome of treatment and submicroscopic evidence of residual disease.
Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization
Authors: Kaat De Clercq, Charlotte Schelfhout, Marc Bracke, Olivier De Wever, Mieke Van Bockstal, Wim Ceelen, Jean Paul Remon, Chris Vervaet
Journal: Biomaterials (2016)
Dysgammaglobulinemia in the Presence of Plasma Cells
Authors: Gerald J. Gleich, John J. Condemi, John H. Vaughan
Journal: New England Journal of Medicine (1965)

AS information about the gamma globulins has increased, it has become apparent that these are a heterogeneous group of proteins, varying in molecular size, antigenicity and electrophoretic mobility1 but having antibody activity in common. For the latter reason, the term immunoglobulin has been proposed to denote these proteins.2 At the present time three major classes of immunoglobulins are recognized, designated gamma2, gamma1A and gamma1M. Gamma globulins may be found in the urine, but here they are predominantly of smaller molecular weight and have been called microgammaglobulins.3 4 5.In the past several years the structures . . .
Rebound Hemodynamic Events after the Abrupt Withdrawal of Nitroprusside in Patients with Severe Chronic Heart Failure
Authors: Milton Packer, Jose Meller, Norma Medina, Richard Gorlin, Michael V. Herman
Journal: New England Journal of Medicine (1979)

We studied the hemodynamic events that followed abrupt withdrawal of nitroprusside in 20 patients with severe chronic heart failure. With nitroprusside, cardiac index increased from 1.96 to 2.87 liters per minute per square meter of body-surface area, but it decreased to 1.66 (P less than 0.001) after withdrawal of nitroprusside. Left ventricular filling pressure and systemic vascular resistance decreased from 23.9 to 15.3 mm Hg and from 1642 to 921 dyn.sec.cm-5, respectively, with nitroprusside, but increased to 30.4 mm Hg and 2109 dyn.sec.cm-5 (both P less than 0.001) upon its discontinuation. These rebound changes were maximal 10 to 30 minutes after nitroprusside withdrawal and returned to control levels one to three hours later. Although in 17 of 20 patients, these rebound changes caused no or minimal exacerbation of symptoms, pulmonary edema, which resolved in three patients. Activation of reflex vasoconstrictive forces during vasodilator therapy may explain these effects of withdrawal.
Psychiatrists and physical examinations: a survey
Authors: C W Patterson
Journal: American Journal of Psychiatry (1978)

Alumni from the 1965-1974 psychiatric residency classes at the Los Angeles County-University of Southern California Medical Center were surveyed about their individual practices regarding physical examinations. Ninety-eight of 155 alumni returned the anonymous questionnaire. None of the respondents routinely performed physical examinations on new outpatients. The 61% who had inpatient practices usually delegated the hospital admission physical examination.
Abstract 13257: FEV1 and FVC predict Mortality in Individuals Without Manifest Lung Disease Independent of Cardiac Performance - Results From the Population-based Gutenberg Health Study
Authors: Christina Baum, Francisco M Ojeda, Philipp S Wild, Nargiz Rzayeva, Tanja Zeller, Christoph R Sinning, Norbert Pfeiffer, Manfred Beutel, Maria Blettner, Karl J Lackner, Stefan Blankenberg, Thomas Munzel, Klaus F Rabe, Renate B Schnabel
Journal: Circulation (2015)

Background: Pulmonary disease has consistently been related to increased mortality. We investigated central spirometry variables in relation to total mortality in individuals from the general population without diagnosed lung disease also accounting for cardiac function. Methods: In 15,010 individuals from the general population (mean age 55±11 years, age range 35-74 years, 50.5% men) in the Gutenberg Health Study we performed spirometry and multimodal transthoracic echocardiography. The biomarkers N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (TnI) were measured in the first 5000 individuals using commercially available assays. Multivariable Cox regression analyses were computed for the lung function parameters forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and the Tiffeneau-Pinelli index (FEV1/FVC ratio) after exclusion of individuals with prevalent pulmonary disease (N=1135). Results: The median FEV1/FVC ratio was 79.1%, 19.5% were current smokers, 4.2% had prevalent heart failure. After a median follow-up of 5.5 years 360 deaths were recorded. Multivariable-adjusted Cox regression analyses for the common cardiovascular risk factors (age, sex, body mass index, current smoking, diabetes mellitus, hypertension, dyslipidemia) and heart failure revealed that an increase of one standard deviation (SD) of FEV1 was associated with a 38% risk reduction (hazard ratio (HR) per SD 0.62 [95% confidence interval (CI): 0.52-0.73]). The association remained statistically highly significant after additional adjustment for ejection fraction, stroke volume, Nt-proBNP or TnI. Comparable results were seen for FVC, whereas no association of FEV1/FVC ratio with mortality could be shown. No significant interaction by heart failure was observed. Conclusions: The central lung function parameters FEV1 and FVC were related to all-cause mortality in individuals without manifest lung disease. Our findings indicate that subtle, subclinical pulmonary impairment constitutes a risk for increased mortality independent of cardiac performance.
Prevention of &lt;italic&gt;N&lt;/italic&gt;-Nitrosobis(2-oxopropyl)amine-Induced Nasal Cavity Tumors in Rats by Orchiectomy&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;3&lt;/xref&gt;
Authors: P M Pour, U Götz
Journal: JNCI Journal of the National Cancer Institute (1983)

Bilateral orchiectomy, performed 1 week before initiation of weekly sc injections of N-nitrosobis(2-oxopropyl)amine (BOP), prevented induction of hyperplastic and neoplastic lesions in the nasal and paranasal cavities of outbred Wistar-derived MRC rats. However, in BOP-treated rats without surgery or with bilateral vesiculectomy, the incidences of these lesions were 100 and 90%, respectively. Literature review indicates that nasal and paranasal lesions occur predominantly in male domestic animals as well as in human males and suggests a possible hormone dependency of these lesions.
A phase II trial addressing the prevalence of chlamydial infection and eradication efficacy of antibiotic therapy in marginal zone lymphoma (OAMZL) and other lymphoproliferative disorders of the ocular adnexae (LPDOA).
Authors: S. Govi, R. Dolcetti, M. Ponzoni, E. Pasini, C. Doglioni, F. Bertoni, F. Cavalli, E. Zucca, A. J. Ferreri
Journal: Journal of Clinical Oncology (2010)

e18520 Background: Retrospective studies showed some geographical variability in the association between OAMZL and Chlamydophila psittaci (Cp), with rates from 0% to 75%. Bacteria eradication with doxycycline (DXC) has been associated with lymphoma regression in 50% of pts, while prolonged contact with infected household animals may determine reinfection and hinder therapeutic efficacy. We designed a phase II trial on pts with newly diagnosed, limited-stage LPDOA aimed to address DXC activity (1ry endpoint), and to investigate related microorganisms and reinfection risk (ClinicalTrials.gov #NCT01010295). Methods: The trial included two parts: A) pts with OAML and measurable disease treated with DXC 100 mg bid for 21 d, and B) pts with any LPDOA not eligible for A who received the best institutional therapy (DXC an option). Tumor tissue, conjunctival swabs and PBMC from all pts were assessed for several bacterial and viral infections by different PCR protocols. Assessments on swabs and PBMC were repeated at 3 and 12 mos from DXC to investigate eradication. Herein, we report data on infections prevalence, bacterial eradication and reinfection risk. Results: 41 pts with LPDOA (OAMZL 36, other lymphomas 2, pseudotumor 3) were enrolled (26 A, 15 B). Tumor samples of 34 pts were assessed for chlamydial infections: Cp was detected in 27/30 OMZL (90%) and in 3/4 non-MZL. Other chlamydiae were not detected. Among Cp+ cases, this bacteria was also detected in conjunctival swabs (100%) and PBMC (79%; 23/29). Swabs and PBMC were negative in pts with Cp- lymphomas. 39 pts received DXC; bacterial eradication was assessed in 20 pts with Cp+ swab or PBMC. At 3 mos from DXC, eradication was confirmed in 35% of swabs and 33% of PBMC. Prolonged contact with animals was similar in eradicated (2/7) and not eradicated (5/13) pts (p=1.00). Conclusions: Cp is common in LPDOA. The failure of Cp eradication with DXC in 2/3 of pts deserves to be better investigated since its potential negative impact on lymphoma regression. This phenomenon seems not to be explained simply by reinfection risk. Response analysis requires a longer follow-up. No significant financial relationships to disclose.
Lung Cancer in Women
Authors: Ernest L. Wynder, Irwin J. Bross, Jerome Cornfield, Walter E. O'Donnell
Journal: New England Journal of Medicine (1956)

ALTHOUGH much has been written about etiologic factors in the development of lung cancer in men during recent years, little has been said about the role of these factors in women. The primary reason for this apparent neglect is the fact that lung cancer is still a rather uncommon disease among women, so that a sufficient number of cases cannot be easily obtained for an epidemiologic survey.The present study is based on environmental data of proved cases of lung cancer in women, all of which were diagnosed in the period 1953 to 1955. The purpose has been to study . . .
P-105 Pembrolizumab (MK-3475) for patients with recurrent or metastatic gastric or gastroesophageal junction (GEJ) adenocarcinoma: The phase 2 KEYNOTE-059 study
Authors: C. Fuchs, A. Denker, J. Tabernero, E. Van Cutsem, A. Ohtsu, B. Lam, M. Koshiji, Y.-J. Bang
Journal: Annals of Oncology (2015)
13-<i>cis</i>-Retinoic Acid in the Treatment of Oral Leukoplakia
Authors: Waun Ki Hong, James Endicott, Loretta M. Itri, Wilhelm Doos, John G. Batsakis, Richard Bell, Stephanie Fofonoff, Robert Byers, E. Neely Atkinson, Charles Vaughan, Bela B. Toth, Alan Kramer, Isaiah W. Dimery, Paulette Skipper, Stuart Strong
Journal: New England Journal of Medicine (1986)

13-cis-Retinoic acid has been reported to be effective in treating oral leukoplakia. We randomly assigned 44 patients with this disease to receive 13-cis-retinoic acid (24 patients) or placebo (20), 1 to 2 mg per kilogram of body weight per day for three months, and followed them for six months. There were major decreases in the size of the lesions in 67 percent (16 patients) of those given the drug and in 10 percent (2 patients) of those given placebo (P = 0.0002); dysplasia was reversed in 54 percent (13 patients) of the drug group and in 10 percent (2 patients) of the placebo group (P = 0.01). The clinical response to the drug correlated with the histologic response in 56 percent (9 of 16) of the patients evaluated. Relapse occurred in 9 of 16 patients two to three months after treatment ended. The toxic effects of the drug were acceptable in all but two patients. Cheilitis, facial erythema, and dryness and peeling of the skin were common; conjunctivitis and hypertriglyceridemia also occurred. All adverse reactions could be reversed by reducing the dose or temporarily discontinuing the drug. We conclude that 13-cis-retinoic acid, even in short-term use, appears to be an effective treatment for oral leukoplakia and has an acceptable level of toxicity.
Abstract 4309: Description of a scientific treatment approach of mast cell leukemia, an aggressive orphan hematologic disorder: strategy based on next-generation sequencing data
Authors: Jeonghwan Youk, Youngil Koh, Ji-Won Kim, Dae-Yoon Kim, Woo June Jung, Kwang-Sung Ahn, Sung-Soo Yoon, Hye Lim Jung
Journal: Cancer Research (2015)

Abstract Background Mast cell leukemia (MCL) is the most aggressive form of disorder among systemic mastocytosis. Due to its rarity, neither pathogenesis nor standard treatment is not established for this orphan disease. Hence, we tried to treat a patient with MCL based on the exome and transcriptome sequencing result of the patient's own DNA and RNA. Brief Case History and Results In October 2013, an 18-year-old Korean female were diagnosed as MCL after visiting our hospital due to left knee, ankle pain and inguinal lymphadenopathy. C-KIT overexpression was observed by immunohistochemistry. Whole exome sequencing result failed to demonstrate either noticeable single nucleotide variant (SNV) or copy number change. Interestingly, whole transcriptome sequencing (WTS) revealed mutation of KIT S476I, functionality of which is not known. Fusion analysis was performed using WTS data, possibility of RARα-B2M fusion has been arised. However, it was not validated by PCR sequencing. When RNA expression analysis was performed using WTS data, upregulation of PIK3/AKT pathway, which is a downstream of KIT (BAD phosphorylation) and mTOR has been observed. For the treatment perspective, she failed to achieve complete remission after cytarabine and idarubicin chemotherapy. Based on our WES and WTS result, we first tried all-trans retinoic acid targeting RARα, which failed to demonstrate efficacy. Then, she received dasatinib targeting KIT, which showed transient response for 2 weeks. Now she is under everolimus targeting mTOR pathway and, further treatment with PI3K inhibitor is planned in case of disease progression. Conclusions We are demonstrating a case of orphan disease, where we used targeted approach using WES and WTS data of the patient. Final results of our treatment outcome will be uncovered shortly, and utility of this kind of approach is to be validated. Citation Format: Jeonghwan Youk, Youngil Koh, Ji-Won Kim, Dae-Yoon Kim, Woo June Jung, Kwang-Sung Ahn, Sung-Soo Yoon, Hye Lim Jung. Description of a scientific treatment approach of mast cell leukemia, an aggressive orphan hematologic disorder: strategy based on next-generation sequencing data. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4309. doi:10.1158/1538-7445.AM2015-4309
Atypical Manifestations of Peripheral Arteriosclerosis
Authors: Edward A. Edwards
Journal: New England Journal of Medicine (1952)

THIS paper considers certain of the more atypical manifestations of peripheral arteriosclerosis and their management. These include murmur production in the peripheral arteries, syndromes of ischemia in circumscribed arterial territories and the peculiar effects of venous thrombosis in the ischemic limb.Murmur Production in the Peripheral ArteriesThat a murmur may be heard over an arteriosclerotic vessel was mentioned by Sahli1 and has recently been emphasized for the aorta by Hiestand and Morris2 and by Popkin.3 Recent work on murmur production has established the value of auscultation in the diagnosis of arteriosclerosis, localizing the site of greatest involvement and, in . . .