tbuckley/cabot-search huggingface dataset:
PWE-370 Colonoscopy comfort and subsequent faecal occult blood screening uptakein the english bowel cancer screening programme
Authors: SH Lo, A Ghanouni, C Rees, M Rutter, J Snowball, H Seaman, S Halloran, J Wardle, C von Wagner
Journal: Gut (2015)

<h3>Introduction</h3> Abnormal guaiac Faecal Occult Blood test (gFOBt) screening results are associated with lower subsequent screening uptake among individuals who are referred back for routine screening (Lo <i><i>et al</i></i>. 2015). Negative experience with a colonoscopy prompted by a positive gFOBt may contribute to an individual’s decision not to repeat screening. This study examined the association between nurse-reported colonoscopy discomfort on subsequent gFOBt screening uptake in the NHS Bowel Cancer Screening Programme (BCSP). <h3>Method</h3> gFOBt uptake of three screening invitation rounds (R1-R3) was recorded for 322,791 individuals aged 60–64 at the time of the first gFOBt screening invitation and living within the catchment area of the Southern Hub of the NHS BCSP. Nurse-reported colonoscopy discomfort scores (no/ minimal/ mild/ moderate/ severe) from a previous episode (R1 or R2) were used to predict repeat gFOBt uptake in R2 and R3 among individuals who remained eligible for routine screening. 1,566 out of 2,489 (63%) individuals who had undergone a colonoscopy in R1 remained eligible for screening in R2. 1,444 out of 5,720 (25%) individuals who had undergone a first colonoscopy in R1 or R2 were eligible for screening in R3. Nurse-reported colonoscopy discomfort scores were recorded for 1,495 out of 1,566 (95%) individuals who were invited for repeat gFOBt screening in R2 and 1,366 out of 1,444 (95%) who were invited for repeat screening in R3. Discomfort scores from second and further colonoscopies were excluded from the analysis, as they were only available for a very small number of patients (n ≤ 44). <h3>Results</h3> Discomfort during the first colonoscopy examination was not associated with subsequent gFOBt screening uptake in R2 (OR = 0.97, 95% CI: 0.84 – 1.11, p = 0.63) or R3 (OR = 0.96, 95% CI: 0.82 – 1.14, p = 0.67). There was, however, evidence of a negative association between discomfort during recovery after the first examination and subsequent gFOBt uptake in R2 (OR = 0.74, 95% CI: 0.56 – 0.99, p = 0.04) and in R3 (OR = 0.66, 95% CI: 0.43 – 1.02, p = 0.06). <h3>Conclusion</h3> Discomfort during a first colonoscopy examination did not appear to be associated with reduced subsequent gFOBt screening uptake, although discomfort during recovery was associated with lower subsequent uptake. Future research should repeat this analysis in a national sample and include adherence to surveillance as an additional outcome for people with intermediate- and high-risk adenomas detected at colonoscopy. <h3>Disclosure of interest</h3> None Declared.
PWE-033 Role of endoscopy in investigating iron deficiency anaemia
Authors: M Mulla, F Ali, D Ellis, R Earland, T Garsaa, N Abdullah
Journal: Gut (2015)

<h3>Introduction</h3> Incidence of Iron Deficiency Anaemia (IDA) is 2–5% in adult men and post-menopausal women. Common causes include colonic or gastric malignancy, coeliac disease, and poor dietary intake. British Gastro-intestinal Society (BSG) recommends both upper and lower GI investigations in all post-menopausal women and male patients. We evaluated the compliance with these BSG guidelines in investigating patients with IDA. <h3>Method</h3> A comprehensive list of all patients referred as ‘IDA’ obtained from endoscopy department. All referrals in the time period of one year from April 2013–14’ were included. All patients were referred as ‘Urgent Suspected Cancer’. Gastroscopy, colonoscopy, flexible sigmoidoscopy and histology reports of all patients were reviewed. <h3>Results</h3> A total of 412 patients were included. 58% of patients had both OGD and colonoscopy. 25.4% of patients had OGD only. Out of 412 patients included, 302 had anaemia and 89 were not anaemic. Out of 302 anaemic patients, only 185 had IDA. 21 patients were found to have colorectal cancer (CRC) out of which 18 (85.7%) had anaemia. This was statistically significant, p = 0.001 (CI: 65.7%, 95.2%). Out of 18 patients with CRC and anaemia, 13 (72%) had IDA. This was not statistically significant (p = 0.062). None of patients aged below 50 years had CRC. When we compared patients aged 50 years or less to patients over, there was a significant difference in detecting CRC (p = 0.004). In patients more than 70 years, for every increase in age by 1 year there was a 6.5% increased risk of having colorectal cancer, p = 0.002 (CI: 1.023, 1.108). In 70 patients (16.9%) serum ferritin was not checked before endoscopic investigations. 44 (14.2%) patients did not have duodenal biopsy taken during OGD. <h3>Conclusion</h3> More than a third of patients did not have both OGD and colonoscopy as per BSG guidelines. Presence of IDA did not increase the risk of getting CRC. None of patients &lt;50 yrs of age had CRC, perhaps age 70 years might be a better criteria. The guidelines were also not followed with regards to serum ferritin and Duodenal biopsies. <h3>Disclosure of interest</h3> None Declared.
PULMONARY EMPHYSEMA: AN EXPERIMENTAL MODEL
Authors: M L JANOWER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Discontinuation of alprazolam treatment in panic patients
Authors: A J Fyer, M R Liebowitz, J M Gorman, R Campeas, A Levin, S O Davies, D Goetz, D F Klein
Journal: American Journal of Psychiatry (1987)

Alprazolam treatment was tapered in 17 panic patients at a rate of 10% of the starting dose every 3 days. Only four subjects completed withdrawal on schedule (4-5 weeks); four additional subjects discontinued treatment in 7-13 weeks. During withdrawal 15 patients had recurrent or increased panic attacks and nine had significant new withdrawal symptoms. Most common among the latter were malaise, weakness, insomnia, tachycardia, lightheadedness, and dizziness. None had seizures, psychosis, or significant neurological or EEG abnormalities. Results indicate that relapse and withdrawal are important considerations in the choice of alprazolam treatment for panic attacks.
Sentinel-Node Biopsy in Melanoma
Authors: J Meirion Thomas
Journal: New England Journal of Medicine (2014)

Thomas suggests that prevention of melanoma recurrence is neither desirable in nor beneficial to patients.This curious position is inconsistent with a trial for which he was principal investigator, which used loco-regional recurrence as the primary end point. 1He equates outcomes from early treatment of nodal metastases with delayed treatment, which MSLT-I clearly disproves.Early treatment, guided by sentinel-node biopsy, halves the extent of nodal involvement at surgery 2 and decreases the rate of surgical complications. 3 Early treatment also results in a clinically and statistically significant decreased risk of death from melanoma among patients with nodal metastases from intermediate-thickness melanomas.His appeal to the NCI actually evoked a clear statement in 2007 from the chief of the Clinical Investigations Branch that the NCI "does not interfere with the peer review process and depends on journal reviewers and editors to fairly referee scientific disagreements" (Abrams J: personal communication).This process was vigorously undertaken by the reviewers and editors of the Journal.Reviewers thought the addition of distant disease-free survival for the entire population (which insignificantly favored the biopsy group [hazard ratio for distant metastasis, 0.89; 95% confidence interval, 0.70 to 1.13; P = 0.34]) did not warrant displacement of the presented results.Thomas's statement that the curves showing the cumulative incidence of nodal metastasis are parallel between 8 and 10 years of follow-up is inaccurate.More than one fourth of the remaining minimal numerical difference between the curves evaporates during those 2 years.The criticism is, in any case, irrelevant since the rates are not statistically different, even with existing follow-up.His repetition of the illogical concept of "prognostic false positivity" therefore remains entirely without merit.Cady comments that a survival benefit in one subgroup may offset a disadvantage in another.In MSLT-I, a separate analysis involving a prospectively defined subgroup of patients with node-positive disease was justified by a strong biologic rationale.Survival
Southern Comfort
Authors: Paul Rousseau
Journal: JAMA (2009)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Julia Rush's diary: coping with loss in the early nineteenth century
Authors: S B Thielman, F T Melges
Journal: American Journal of Psychiatry (1986)

Julia Rush (1759-1848), wife of Benjamin Rush (1745-1813), recorded her thoughts over a 33-year period in an unpublished devotional journal. Many of the entries relate to her experience of the loss of Benjamin Rush. Although the diary is inadequate as a source of understanding psychodynamic processes at work, it provides considerable information about Julia Rush's coping behavior. An analysis of this journal reveals that she used three major coping strategies to deal with the loss of her husband: ritualized language, time marking, and cognitive reframing. These devotional meditations also illuminate the way early nineteenth-century religious views shaped Julia Rush's response to loss.
Malignancy of Gastric Cancer&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: William A. Meissner, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Malignancy of Gastric Cancer12 William A. Meissner, M. D. William A. Meissner, M. D. Laboratories of Pathology, New England Deaconess Hospital, and Harvard Cancer Commission, Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 533–543, https://doi.org/10.1093/jnci/10.2.533 Published: 01 October 1949
Investigation of Drug Interaction Between Warfarin and Gemcitabine -Increase in Anticoagulant Effect of Warfarin-
Authors: Hideyuki Kushihara, Tomoe Kushihara, Kenji Kawada, Chihiro Kondoh, Michitaka Nagase, Yoshiaki Fukui, Toshio Mizutani, Nagisa Hamajima, Fumio Nomura, Kazuhiro Mori
Journal: Annals of Oncology (2014)
Squamous Papilloma in the White Croaker
Authors: Russell, Findlay E., Kotin, Paul
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Squamous Papilloma in the White Croaker Get access Findlay E. Russell, Findlay E. Russell Laboratory of Neurological Research, College of Medical Evangelists, and Department of Pathology, University of Southern California, Los Angeles County General Hospital, Los Angeles, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul Kotin Paul Kotin Laboratory of Neurological Research, College of Medical Evangelists, and Department of Pathology, University of Southern California, Los Angeles County General Hospital, Los Angeles, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 6, June 1957, Pages 857–861, https://doi.org/10.1093/jnci/18.6.857 Published: 01 June 1957 Article history Received: 07 March 1957 Published: 01 June 1957
AB0125 Differential Expression of Vascular Inflammation Markers in Collagen-Induced Arthritis and Experimental Atherosclerosis
Authors: A. Denys, G. Clavel, D. Lemeiter, O. Schischmanoff, E. Assier, M.-C. Boissier, L. Semerano
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Cardiovascular disease (CVD) is a major cause of morbidity and mortality in rheumatoid arthritis (RA). Increased cardiovascular risk in RA is attributed to both traditional risk factors and systemic inflammation over a long period. Limited experimental data exist on vascular involvement in arthritis models<sup>1,2,3</sup>. Thus, we developed a model that would mimic both vascular dysfunction and articular inflammation in RA, using collagen-induced arthritis (CIA) in in C57Bl/6 (B6) mice. <h3>Objectives</h3> To study the expression of vascular inflammatory markers and atheroma formation in CIA with and without concomitant hyperlipidic diet (HD). <h3>Methods</h3> CIA was induced in B6 mice with chicken type-II collagen (cCII) followed by a boost 21 days later. These mice were fed with a standard (chow) diet or with HD given for 12 weeks starting from the day of the boost. The control mice were not immunized (NI) but were fed either the standard diet or HD. Arthritis severity was evaluated using a validated clinical score. Aorta and synovial membranes were removed 15 weeks after the first cCII immunization. We analysed vascular cell adhesion molecule-1 (VCAM-1), inducible NO-synthase (iNOS) and interleukin-17 mRNA level in aorta with real-time quantitative PCR. VCAM-1 localisation in the aortic sinus was determined by immunohistochemistry. In addition, atherosclerotic plaques were assessed in the aorta. <h3>Results</h3> CIA was associated with high expression of VCAM-1, independently of the fed diet. VCAM-1 overexpression was detectable 4 weeks after cCII immunization and persisted at 15 weeks. HD induced atheroma plaque formation and aortic iNOS expression which were both independent from CIA. Concomitant CIA and HD had no additive effect on atheroma, VCAM-1 or iNOS expression. <h3>Conclusions</h3> In B6 mice, HD and CIA induce distinct and independent expression of large vessel inflammation markers. This model, sensitive to both CIA and experimental atherosclerosis may be relevant for the study of CVD in RA. <h3>References</h3> Asquith, D. L., Miller A. M., Hueber A. J., et al. Apolipoprotein E-deficient mice are resistant to the development of collagen-induced arthritis. Arthritis Rheum 2010.62:472-7. Postigo, J., Genre F., Iglesias M., et al. Exacerbation of type II collagen-induced arthritis in apolipoprotein E-deficient mice in association with the expansion of Th1 and Th17 cells. Arthritis Rheum 2011.63:971-80. Rose, S., Eren M., Murphy S., et al. A novel mouse model that develops spontaneous arthritis and is predisposed towards atherosclerosis. Ann Rheum Dis 2013.72:89-95. <h3>Disclosure of Interest</h3> None declared
FDA Approves First Biosimilar, Zarxio
Authors: Janet Colwell
Journal: Cancer Discovery (2015)

Abstract Sandoz's Zarxio, a version of Amgen's Neupogen, which treats neutropenia in cancer patients, is the first biosimilar drug to be approved by the FDA. Other biosimilar products are poised to enter the U.S. market, potentially leading to lower prices for biologics.
Physiology of Coronary Circulation
Authors: G Pandolfo
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Letters to the Editor: reply
Authors: Gertrude Kohn, M.D.
Journal: JNCI Journal of the National Cancer Institute (1971)

Journal Article Letters to the Editor: reply Get access Gertrude Kohn, M.D. Gertrude Kohn, M.D. Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19146 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 46, Issue 3, March 1971, Pages 685–686, https://doi.org/10.1093/jnci/46.3.685 Published: 01 March 1971
Screening for Syphilis Infection in Nonpregnant Adults and Adolescents
Authors: Kirsten Bibbins-Domingo, David C. Grossman, Susan J. Curry, Karina W. Davidson, John W. Epling, Francisco A. R. García, Matthew W. Gillman, Diane M. Harper, Alex R. Kemper, Alex H. Krist, Ann E. Kurth, C. Seth Landefeld, Carol M. Mangione, William R. Phillips, Maureen G. Phipps, Michael P. Pignone
Journal: JAMA (2016)

<h3>Importance</h3> In 2014, 19 999 cases of syphilis were reported in the United States. Left untreated, syphilis can progress to late-stage disease in about 15% of persons who are infected. Late-stage syphilis can lead to development of inflammatory lesions throughout the body, which can lead to cardiovascular or organ dysfunction. Syphilis infection also increases the risk for acquiring or transmitting HIV infection. <h3>Objective</h3> To update the 2004 US Preventive Services Task Force (USPSTF) recommendation on screening for syphilis infection in nonpregnant adults. Screening for syphilis in pregnant women was updated in a separate recommendation statement in 2009 (A recommendation). <h3>Evidence Review</h3> The USPSTF reviewed the evidence on screening for syphilis infection in asymptomatic, nonpregnant adults and adolescents, including patients coinfected with other sexually transmitted infections (such as HIV). <h3>Findings</h3> The USPSTF found convincing evidence that screening for syphilis infection in asymptomatic, nonpregnant persons at increased risk for infection provides substantial benefit. Accurate screening tests are available to identify syphilis infection in populations at increased risk. Effective treatment with antibiotics can prevent progression to late-stage disease, with small associated harms, providing an overall substantial health benefit. <h3>Conclusions and Recommendation</h3> The USPSTF recommends screening for syphilis infection in persons who are at increased risk for infection. (A recommendation)
Progressive Muscular Dystrophy
Authors: L Bussi
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal