tbuckley/cabot-search huggingface dataset:
Bronchodilator Therapy
Authors: David C. Webb-Johnson, Joseph L. Andrews
Journal: New England Journal of Medicine (1977)

MethylxanthinesMethylxanthines cause bronchodilatation in synergy with sympathomimetics and have been reviewed fully in this journal.23,24 Theophylline can be given by mouth or by rectum. However, its low solubility makes gastrointestinal absorption erratic, and its local irritative effect on the stomach causes nausea, vomiting and abdominal distress. High blood levels of theophylline can cause the same symptoms. Aminophylline, the ethylenediamine salt of theophylline, is 20 times more soluble and can be given intravenously as well as by mouth or by rectal suppository. The other main side effect of all the methylxanthines is excitation of the central nervous system, causing irritability . . .
Le paludisme d'importation en France métropolitaine en 1996
Authors: F Legros, M Belkaid, M Danis
Journal: Eurosurveillance (1998)

En France, le paludisme n'est plus endemique depuis 1960, bien que des cas sporadiques aient ete rapportes jusqu'en 1970 dans le departement de la Corse. Depuis lors, aucun cas autochtone de paludisme n'a ete declare. Les donnees epidemiologiques du paludisme d'importation pour l'annee 1996 sont presentees ci-dessous (1).
Retrozymes are a unique family of non-autonomous retrotransposons with hammerhead ribozymes that propagate in plants through circular RNAs
Authors: Amelia Cervera, Denisse Urbina, Marcos de la Peña
Journal: Genome biology (2016)

Catalytic RNAs, or ribozymes, are regarded as fossils of a prebiotic RNA world that have remained in the genomes of modern organisms. The simplest ribozymes are the small self-cleaving RNAs, like the hammerhead ribozyme, which have been historically considered biological oddities restricted to some RNA pathogens. Recent data, however, indicate that small self-cleaving ribozymes are widespread in genomes, although their functions are still unknown.We reveal that hammerhead ribozyme sequences in plant genomes form part of a new family of small non-autonomous retrotransposons with hammerhead ribozymes, referred to as retrozymes. These elements contain two long terminal repeats of approximately 350 bp, each harbouring a hammerhead ribozyme that delimitates a variable region of 600-1000 bp with no coding capacity. Retrozymes are actively transcribed, which gives rise to heterogeneous linear and circular RNAs that accumulate differentially depending on the tissue or developmental stage of the plant. Genomic and transcriptomic retrozyme sequences are highly heterogeneous and share almost no sequence homology among species except the hammerhead ribozyme motif and two small conserved domains typical of Ty3-gypsy long terminal repeat retrotransposons. Moreover, we detected the presence of RNAs of both retrozyme polarities, which suggests events of independent RNA-RNA rolling-circle replication and evolution, similarly to that of infectious circular RNAs like viroids and viral satellite RNAs.Our work reveals that circular RNAs with hammerhead ribozymes are frequently occurring molecules in plant and, most likely, metazoan transcriptomes, which explains the ubiquity of these genomic ribozymes and suggests a feasible source for the emergence of circular RNA plant pathogens.
What comes next after Brexit vote, scientists ask
Authors: Anne Gulland
Journal: BMJ (2016)

Health experts and scientists have been reacting to today’s news that the United Kingdom has voted to leave the European Union.

Scientists and researchers, who have been among the strongest supporters for remaining in the EU, have been reacting with dismay at the news.

Paul Nurse, director of the Francis Crick Institute and former president of the Royal Society, described the referendum result as a “poor outcome for British science.”

“Science thrives on the permeability of ideas and people and flourishes in environments that pool intelligence, minimise barriers, and are open to free exchange and collaboration. British scientists will have to work hard in the future to counter the isolationism of Brexit if our science is to continue to thrive,” he said.

Robert Lechler, president of the Academy of Medical Sciences, said that …
Postgraduate diploma and masters (MA) in clinical education
Authors: Muhammed Ashraf Memon
Journal: BMJ (2007)

FURTHER INFORMATION 

Cathy Sherratt, Programme Leader, MA Clinical Education, Edge Hill, St Helens Road, Ormskirk L39 4QP Tel +44 01695 584154 sherrattc@edgehill.ac.uk.



It is a modular course taught by Edge Hill University and accredited by the University of Lancaster. The aims of this multiprofessional course are to improve teaching skills and understand how individuals learn in a clinical environment.

The postgraduate diploma/masters is designed for health professionals (medical doctors, dentists, and allied health professions) involved in teaching, supporting the learning of staff or students, and assessing or evaluating teaching as part of their current or planned role.

The …
Meningococcal a and Other Polysaccharide Vaccines
Authors: Martha L. Lepow, Ronald Gold
Journal: New England Journal of Medicine (1983)

Five years ago, the Journal 1 published the results of a successful field trial with a Group A meningococcal polysaccharide vaccine conducted in children between three months and five years of age during an epidemic of meningococcal A disease in Finland. The Finnish study included 130,000 children who received meningococcal Group A vaccine; 49,000 who received Hemophilus influenzae Type b polysaccharide vaccine, which had been developed by Smith and co-workers2; and 32,000 unvaccinated controls. No cases of meningococcal A disease occurred during the first year after vaccination in the group that received Group A vaccine, whereas 6 and 13 cases . . .
Why Are There So Many Mastectomies in the United States?
Authors: Anita Mamtani, Monica Morrow
Journal: Annual Review of Medicine (2016)

Breast-conserving therapy (BCT) and mastectomy result in equivalent long-term survival. Locoregional recurrence rates after BCT have decreased over time and are now similar to those after mastectomy. Contralateral breast cancer rates are declining as well owing to the widespread use of adjuvant systemic therapy. Despite these improved outcomes, increasing rates of bilateral mastectomy for unilateral cancer have been observed in the United States. Medical indications for mastectomy are well defined and present in a minority of patients, and women at increased risk for contralateral cancer are a small proportion of the breast cancer population. Evidence indicates that increasing use of mastectomy is a patient-driven trend that is most pronounced among younger, educated, and well-insured women, and reflects fear of recurrence and in some cases misunderstanding of future cancer risks. Although satisfaction levels are generally high among patients choosing contralateral prophylactic mastectomy, complications and procedure extent may be underestimated. Improved communication strategies are essential to facilitate this complex decision-making process.
Productivity of mental health professionals in a prepaid health plan
Authors: T J Craig, D Y Patterson
Journal: American Journal of Psychiatry (1981)

To determine staff productivity in the psychiatry department of a prepaid health plan, the authors compared hours of direct service with professional time available. Psychiatrists exceeded the time standards set, and other staff achieved about three-fourths of the initial standards. The findings provided a basis for refining the standards for each professional discipline. Establishing flexible productivity standards in a system that promotes open discussion and provides continuing positive feedback promotes more efficient scheduling, which can significantly increase service time in the face of limited resources.
Health Insurance for Emergency Hospitalization—Isn’t the Point to Pay the Bill?
Authors: Mitchell H. Katz
Journal: JAMA Internal Medicine (2016)

Emily R. Adrion, PhD, MSc; Andrew M. Ryan, PhD; Amanda C. Seltzer, MHSA; Lena M. Chen, MD, MS; John Z. Ayanian, MD, MPP; Brahmajee K. Nallamothu, MD, MPH
Quality of Life (Qol) Associated with Lanreotide Autogel (Lan) Treatment for Carcinoid Syndrome (Cs) in Gastroenteropancreatic Neuroendocrine Tumour (Gepnet) Patients: Results of the Elect Study
Authors: E. Gomez-Panzani, A.I. Vinik, E.M. Wolin, H. Audry
Journal: Annals of Oncology (2014)
Rationale, application and clinical qualification for NT-proBNP as a surrogate end point in pivotal clinical trials in patients with AL amyloidosis
Authors: G Merlini, I Lousada, Y Ando, A Dispenzieri, M A Gertz, M Grogan, M S Maurer, V Sanchorawala, A Wechalekar, G Palladini, R L Comenzo
Journal: Leukemia (2016)

Amyloid light-chain (LC) amyloidosis (AL amyloidosis) is a rare and fatal disease for which there are no approved therapies. In patients with AL amyloidosis, LC aggregates progressively accumulate in organs, resulting in organ failure that is particularly lethal when the heart is involved. A significant obstacle in the development of treatments for patients with AL amyloidosis, as well as for those with any disease that is rare, severe and heterogeneous, has been satisfying traditional clinical trial end points (for example, overall survival or progression-free survival). It is for this reason that many organizations, including the United States Food and Drug Administration through its Safety and Innovation Act Accelerated Approval pathway, have recognized the need for biomarkers as surrogate end points. The international AL amyloidosis expert community is in agreement that the N-terminal fragment of the pro-brain natriuretic peptide (NT-proBNP) is analytically validated and clinically qualified as a biomarker for use as a surrogate end point for survival in patients with AL amyloidosis. Underlying this consensus is the demonstration that NT-proBNP is an indicator of cardiac response in all interventional studies in which it has been assessed, despite differences in patient population, treatment type and treatment schedule. Furthermore, NT-proBNP expression is directly modulated by amyloidogenic LC-elicited signal transduction pathways in cardiomyocytes. The use of NT-proBNP will greatly facilitate the development of targeted therapies for AL amyloidosis. Here, we review the data supporting the use of NT-proBNP, a biomarker that is analytically validated, clinically qualified, directly modulated by LC and universally accepted by AL amyloidosis specialists, as a surrogate end point for survival.
CD271 Expression on Patient Melanoma Cells Is Unstable and Unlinked to Tumorigenicity
Authors: Samantha E. Boyle, Clare G. Fedele, Vincent Corbin, Elisha Wybacz, Pacman Szeto, Jeremy Lewin, Richard J. Young, Annie Wong, Robert Fuller, John Spillane, David Speakman, Simon Donahoe, Miklos Pohl, David Gyorki, Michael A. Henderson, Ricky W. Johnstone, Anthony T. Papenfuss, Mark Shackleton
Journal: Cancer Research (2016)

The stability of markers that identify cancer cells that propagate disease is important to the outcomes of targeted therapy strategies. In human melanoma, conflicting data exist as to whether hierarchical expression of CD271/p75/NGFR (nerve growth factor receptor) marks cells with enriched tumorigenicity, which would compel their specific targeting in therapy. To test whether these discrepancies relate to differences among groups in assay approaches, we undertook side-by-side testing of published methods of patient-derived melanoma xenografting (PDX), including comparisons of tissue digestion procedures or coinjected Matrigel formulations. We found that CD271(-) and CD271(+) melanoma cells from each of seven patients were similarly tumorigenic, regardless of assay variations. Surprisingly variable CD271 expression patterns were observed in the analyses of sibling PDX tumors (n = 68) grown in the same experiments from either CD271(-) or CD271(+) cells obtained from patients. This indicates unstable intratumoral lineage relationships between CD271(-) and CD271(+) melanoma cells that are inconsistent with classical, epigenetically based theories of disease progression, such as the cancer stem cell and plasticity models. SNP genotyping of pairs of sibling PDX tumors grown from phenotypically identical CD271(-) or CD271(+) cells showed large pairwise differences in copy number (28%-48%). Differences were also apparent in the copy number profiles of CD271(-) and CD271(+) cells purified directly from each of the four melanomas (1.4%-23%). Thus, CD271 expression in patient melanomas is unstable, not consistently linked to increased tumorigenicity and associated with genetic heterogeneity, undermining its use as a marker in clinical studies. Cancer Res; 76(13); 3965-77. ©2016 AACR.
Case 41-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Jane F. Desforges, Eugene J. Mark
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 27-year-old woman with past idiopathic thrombocytopenic purpura was admitted to the hospital because of headache, recurrent thrombocytopenia, and a question of intracranial hemorrhage.She was well until nine years earlier, when viral hepatitis B developed without an obvious source and resolved promptly, without complications. Two years later idiopathic thrombocytopenic purpura occurred and did not respond to the administration of prednisone. A splenectomy was performed at this hospital; platelet transfusions were administered during the operation because of bleeding. The platelet count returned promptly to normal; all platelet counts during the next five years were normal. The patient . . .
Dendritic Cells Can Be Primed to Concurrently Activate Both Unconventional Gamma/delta and Conventional alpha/beta T Cells.
Authors: Francesca Fiore, Barbara Castella, Barbara Nuschak, Raffaello Bertieri, Sara Mariani, Serena Zappia, Marta Coscia, Mario Boccadoro, Massimo Massaia
Journal: Blood (2006)
William Ray Bryan 1905-1976
Authors: Joseph W. Beard, Vincent Groupé, John B. Moloney
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article William Ray Bryan 1905-1976 Get access Joseph W. Beard, Joseph W. Beard Life Sciences, Inc., 2900 72d Street, North, St. Petersburg, Florida 33710 Search for other works by this author on: Oxford Academic PubMed Google Scholar Vincent Groupé, Vincent Groupé Life Sciences, Inc., 2900 72d Street, North, St. Petersburg, Florida 33710 Search for other works by this author on: Oxford Academic PubMed Google Scholar John B. Moloney John B. Moloney National Cancer Institute, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare, Bethesda, Maryland 20014 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 57, Issue 2, August 1976, Pages 231–232, https://doi.org/10.1093/jnci/57.2.231 Published: 01 August 1976
P0972 : Expressions of bile acid transporters are inversely correlated with NAFLD activity score in the liver of patients with non-alcoholic fatty liver disease
Authors: K. Okushin, T. Tsutsumi, K. Enooku, A. Kado, H. Fujinaga, K. Moriya, H. Yotsuyanagi, K. Koike
Journal: Journal of Hepatology (2015)
Moderate physical activity in older adults is not associated with reduced cardiovascular events
Authors: Jacqui Wise
Journal: BMJ (2016)

A moderately intensive physical activity programme for older people was not associated with reduced cardiovascular events, a randomised controlled trial published in JAMA Cardiology has found.1

The Lifestyle Interventions and Independence for Elders (LIFE) study included 1635 sedentary men and women aged 70 to 89 who were functionally limited but able to walk 400 m. The cohort had a high prevalence of cardiovascular risk factors at baseline, …
Serial Cardiac Troponin Measured Using a High-Sensitivity Assay in Stable Patients With Ischemic Heart Disease
Authors: Marc P. Bonaca, Ryan G. O’Malley, Petr Jarolim, Benjamin M. Scirica, Sabina A. Murphy, Michael J. Conrad, Christopher P. Cannon, Harvey D. White, Eugene Braunwald, David A. Morrow, Marc S. Sabatine
Journal: Journal of the American College of Cardiology (2016)
Outbreaks of influenza and influenza-like illness in schools in England and Wales, 2005/06
Authors: H Zhao, C A Joseph, N Phin
Journal: Eurosurveillance (2007)

In England and Wales, clinical reports from primary care showed that influenza activity for the season 2005/06 only rose above the base line for four weeks during February 2006. However, outbreaks of influenza-like illness and/or gastrointestinal infection in schools began to be reported to the Health Protection Agency, Centre for Infections in early January 2006. To quantify the type, size and the spread of these outbreaks a reporting form was distributed to local Health Protection Units in England and to Wales for retrospective and prospective weekly completion. Between weeks 48/05 and 11/06, a total of 688 school outbreaks were reported, including 658 outbreaks of influenza-like illness with or without other symptoms. The remaining 30 outbreaks listed as gastrointestinal only were excluded from the present analysis. Influenza B was confirmed in 70 outbreaks where testing took place. 61% of the outbreaks were reported from primary schools for children aged 4-11 years. This large scale outbreak in school children with flu-like illness across England and Wales was not picked up by most of the routine surveillance schemes, therefore, we believe that a school absentee monitoring and reporting system may be needed to give an early warning of increased influenza activity, especially for the mild form of the disease caused by influenza B virus
The genetics of schizophrenia: a reassessment using modern criteria
Authors: R Abrams, M A Taylor
Journal: American Journal of Psychiatry (1983)

The authors present two reasons for reassessing familial transmission of schizophrenia: recent major changes in diagnostic criteria and methodological weaknesses of older studies. Their own study of this subject employed narrowly defined, operational research criteria; prospective proband selection; semistructured family interviews; and blind, independent diagnoses of probands and relatives. For 30 schizophrenic probands they found an age-corrected morbidity risk in first-degree relatives of 1.61%, a figure that would only support familial transmission if the true population prevalence of schizophrenia were .2% or less. The authors conclude that the case for familial transmission of narrowly defined schizophrenia is weak and suggest alternative hypotheses.
Calla Lilies
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC‐Derived Endothelial Cells
Authors: Hasan E. Abaci, Zongyou Guo, Abigail Coffman, Brian Gillette, Wen‐han Lee, Samuel K. Sia, Angela M. Christiano
Journal: Advanced Healthcare Materials (2016)

Vascularization of engineered human skin constructs is crucial for recapitulation of systemic drug delivery and for their long-term survival, functionality, and viable engraftment. In this study, the latest microfabrication techniques are used and a novel bioengineering approach is established to micropattern spatially controlled and perfusable vascular networks in 3D human skin equivalents using both primary and induced pluripotent stem cell (iPSC)-derived endothelial cells. Using 3D printing technology makes it possible to control the geometry of the micropatterned vascular networks. It is verified that vascularized human skin equivalents (vHSEs) can form a robust epidermis and establish an endothelial barrier function, which allows for the recapitulation of both topical and systemic delivery of drugs. In addition, the therapeutic potential of vHSEs for cutaneous wounds on immunodeficient mice is examined and it is demonstrated that vHSEs can both promote and guide neovascularization during wound healing. Overall, this innovative bioengineering approach can enable in vitro evaluation of topical and systemic drug delivery as well as improve the potential of engineered skin constructs to be used as a potential therapeutic option for the treatment of cutaneous wounds.
Cluster Analysis Followed by Network Meta-Analysis to Compare Efficacy and Safety of Dabigatran, Rivaroxaban and Apixaban After Elective Total Knee and Hip Replacement Surgery
Authors: Job Harenberg, Svetlana Marx, Shabnam Zolfaghari, Christel Weiss, Martin Wehling, Astrid Schulze, Ola E Dahl
Journal: Blood (2012)
Mutations In SETBP1 Occur In 3.1% Of De Novo AML and Show a Distinct Genetic Pattern That Highly Resembles Atypical CML
Authors: Manja Meggendorfer, Tamara Alpermann, Elisabeth Sirch, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, Susanne Schnittger
Journal: Blood (2013)
Effect of first-line treatment on second primary malignancies and Richter’s transformation in patients with CLL
Authors: C Maurer, P Langerbeins, J Bahlo, P Cramer, A M Fink, N Pflug, A Engelke, J von Tresckow, G Kovacs, S Stilgenbauer, C-M Wendtner, L Müller, M Ritgen, T Seiler, K Fischer, M Hallek, B Eichhorst
Journal: Leukemia (2016)
Surveillance du variant de la maladie de Creutzfeldt- Jakob au Royaume-Uni
Authors: H J T Ward
Journal: Eurosurveillance (2000)

Fin mai 2000, 54 cas confirmes de nouveau variant de la maladie de Creutzfeldt-Jakob (nvMCJ) et 13 cas probables ont ete recenses au Royaume-Uni par l’Unite de Surveillance Nationale de la MCJ, mise en place en 1990. Tous les cas certains pour lesquels les donnees etaient disponibles sont homozygotes pour la methionine au codon 129 du gene codant la proteine du prion (PrP). Hormis cette surveillance a l’echelle nationale, cette unite participe a des projets en collaboration tels EUROCJD et NEUROCJD, finances par la Commission Europeenne, dont l’objectif est de comparer les donnees entre les pays afin d’aider a identifier de nouveaux facteurs de risque.