tbuckley/cabot-search huggingface dataset:
AB0230 Relationship between Haq, DAS28 and Radiological Damage with Functional Capacity of the Hand in Rheumatoid Arthritis:
Authors: C. Nuñez-Cornejo Piquer, C. Nuñez-Cornejo Palomares, J. Ivorra Cortes, E. Grau, I. Chalmeta Verdejo, C. Molina Almela, I. Martinez Cordellat, C. Feced Olmos, L. Gonzalez Puig, C. Alcañiz Escandell, J.L. Valero Sanz, R. Negueroles Albuixech, M.L. Muñoz Guillen, J.A. Roman Ivorra
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic inflammatory disease that primarily affects the joints, leading to disability. There are tools such as the HAQ for assessing the patient9s disability but few studies associate this parameter to objective measurements. Biomechanical studies are an effective tool for determining functional capacity, so it would be useful to correlate them with other disability evaluation tools such as HAQ, as well as disease activity parameters. <h3>Objectives</h3> To analyze the correlation between biomechanical studies of the hand with disability, disease activity and structural damage in RA patients. <h3>Methods</h3> We have included 81 RA patients. The DAS28 score was used as a measure of disease activity and HAQ as a disability indicator, evaluated at the same time as the biomechanical study. Structural damage was measured using the Van der Heijde-Sharp score. Hand muscle strength was measured with a hand-held dynamometer. The data were analyzed using linear regression, robust regression and logistic regression. <h3>Results</h3> We included 81 RA patients with DAS28 scores ranging between 1.25 and 7.61, and HAQ scores between 0 and 3. The erosion score was 0-51 (mean of 0 for both hands) and grip strength between 0-52 (means of 6 for right hand and 4 for the left). Using a biomechanical assessment, the disability and relative strength index (RSI) percent values are shown in the table. Biostatistical analysis shows that for every point that the HAQ increases in the hand, there is an increase of about 5% in RSI and 2% in percentage of disability with a p-value less than 0.0001. There is also a statistically significant direct relationship between the increase in the DAS28 score and increasing LSI and hand disability. In addition, a statistically significant positive relationship is seen between LSI and disability, with structural damage, grip strength and erosions in the hand. <h3>Conclusions</h3> There is a direct relationship between increased disability as assessed by biomechanical parameters with increasing HAQ scores, as well as disease activity and structural damage in RA patients. This result shows that disability can be measured more objectively in clinical practice since there is a correlation between the HAQ score, disease activity and structural damage to the hand on biomechanical measurements. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4977
Scientists Grapple With Silicones, Breast Implant Research
Authors: L. F. Anderson
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Scientists Grapple With Silicones, Breast Implant Research Get access Linda F. Anderson Linda F. Anderson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 9, 3 May 1995, Pages 634–635, https://doi.org/10.1093/jnci/87.9.634 Published: 03 May 1995
Abstract 224: TOPK phosphorylation of MKP1 prevents solar ultraviolet irradiation-induced inflammation by inhibiting p38 signaling
Authors: Shengqing Li, Feng Zhu, Tatyana Zykova, Myoung Ok Kim, Ann M. Bode, Cong Peng, Weiya Ma, Zigang Dong
Journal: Cancer Research (2012)

Abstract Solar ultraviolet (UV) irradiation is a major environmental factor that causes DNA damage, inflammation, and skin cancer. T-LAK cell-originated protein kinase (TOPK) is widely expressed in both normal and cancer cells and functions to inhibit apoptosis and promote carcinogenesis. However, its function in inflammation is not known. The p38 MAPK signaling pathway plays an important role in solar UV light-induced inflammation. The phosphorylation level of p38 was reported to be up-regulated after transfection of the TOPK gene into COS-7 cells. We found that the phosphorylation level of p38α was increased in TOPK-/- mouse embryonic fibroblasts (MEFs) compared with TOPK+/+ MEFs after stimulation with solar UV light. Our observations unveil a novel role for TOPK. We found that TOPK negatively regulated the activity of p38α by phosphorylating the p38α-specific phosphatase MKP1 and enhancing the stability of MPK1. Notably, the absence of TOPK in mice resulted in a striking increase in skin inflammation. Therefore, we conclude that TOPK has a protective function in solar UV light-induced inflammation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 224. doi:1538-7445.AM2012-224
Abstract 1156: Applying targeted Next-Gen Sequencing and miRNA expression profiling for cancer biomarker discovery
Authors: Jack T. Leonard
Journal: Cancer Research (2010)

Abstract The Biomarker Discovery Center in Heidelberg, Germany develops new approaches to cancer biomarker identification and validation using high throughput targeted next-generation sequencing and miRNA assays to characterize patient samples from the German Cancer Research Center (DKFZ) and other leading research institutions. Using HybSelect™, febit's product for sequence capture, we demonstrated high throughput processing of patient samples upstream of targeted Next-Gen Sequencing. Overlapping probes were designed to capture the genomic regions of interest (i.e., targets), and then the Geniom Biochips were synthesized for the HybSelect procedure. DNA libraries were prepared from clinical specimens using bar-coded sequencing adaptors from Life Technologies, and the targets were enriched using the HybSelect Sequence Capture Protocol. Bar-coded targets from hundreds of patient samples were sequenced using a SOLiD System with a febit Geniom RT Analyzer. The variants were compared to the reference sequences from healthy individuals. In a related study, changes in miRNA expression profiles were examined in certain cancers. The relative stability of miRNA and the relatively accessible nature of bodily fluids such as blood make miRNA a promising molecule for cancer biomarker discovery. For evaluation of the miRNA expression profiles of cancer patients, we utilized a Microfluidic Primer Extension Assay (MPEA), which starts with the hybridization of unlabeled total RNA samples to Geniom miRNA Biochips. After hybridization, selective enzymatic elongation of the correctly hybridized miRNAs was carried out with biotinylated nucleotides, and then detected with SAPE (streptavidin-conjugated phycoerythrin). The content included on Geniom miRNA Biochips was based on the latest Sanger miRBase update, thus guaranteeing that all human miRNAs, including the most recently validated miRNAs were addressed. With only 130 ng of total RNA required, this method dramatically reduced the amount of sample needed to reliably measure miRNAs and to develop predictive miRNA signatures. Analyses of complex miRNA expression patterns in blood of cancer patients compared to those of healthy donors allowed for distinct classification of the samples. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1156.
A COMPARISON BETWEEN TWO DIFFERENT DEFINITIONS OF CONTRAST-INDUCED ACUTE KIDNEY INJURY IN PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION UNDERGOING PRIMARY PERCUTANEUOS CORONARY INTERVENTION
Authors: Marco Centola, Stefano Lucreziotti, Diego Salerno-Uriarte, Carlo Sponzilli, Giulia Ferrante, Mario Cozzolino, Federico Lombardi, Stefano Carugo
Journal: Journal of the American College of Cardiology (2016)
Hallucal Sesamoiditis Manifested on Bone Scan
Authors: Rong-Hsin Yang, Yum-Kung Chu
Journal: Clinical Nuclear Medicine (2013)

The first metatarsal articulation bears one third of the weight of the forefoot. The hallucal sesamoids are embedded in the flexor hallucis brevis and connected by the intersesamoid ligament and plantar plate. The sesamoid apparatus acts as a pulley to help pull the big toe down against the ground during walking. Repetitive pressure, force, or tension can cause sesamoiditis. If the impact is great enough, the bones can break. Here we present a woman with big toe pain during walking. Our case highlights the role of 99mTc-MDP bone scan in reaching the diagnosis of hallucal sesamoiditis.
Open letter calls for global treaty to tackle obesity
Authors: J. Wise
Journal: BMJ (2014)

Health campaigners have called for a global treaty to promote healthy diets and tackle obesity, modelled on the World Health Organization’s Framework Convention on Tobacco Control.

An open letter from the World Obesity Federation, the UK Health Forum, and consumer groups has been sent to the heads of WHO and the Food and Agriculture Organization.1 It was sent on the eve of the Second International Conference on …
Preventive Anthelmintic Chemotherapy — Expanding the Armamentarium
Authors: Lorenzo Savioli
Journal: New England Journal of Medicine (2014)

In 2012, more than 260 million tablets of albendazole (at a dose of 400 mg) and mebendazole (at a dose of 500 mg) were distributed to school-age children as preventive chemotherapy against soil-transmitted helminthiases; altogether, more than 700 million people received such treatment.1,2 Preventive chemotherapy means large-scale preventive treatment against human helminthiasis and trachoma with the use of safe, single-dose, quality-assured medicines.1 Regular treatment of at-risk populations is used as a public health tool to prevent illness and, for certain infections, to reduce transmission.1,3 The strategy relies on large-scale donations of medicines every year by the pharmaceutical industry, . . .
Neurallergic Reaction to Intravenous Urography
Authors: Robert G. Feldman, Lewis L. Levy, Gilbert H. Glaser
Journal: New England Journal of Medicine (1962)

THIS report concerns a case of severe, nonfatal encephalopathy associated with a systemic allergic reaction occurring after the intravenous administration of sodium diatrizoate (Hypaque).The introduction of materials consisting of a triiodinated benzoic acid nucleus and one or more acylamino radicals was considered an advance in the search for safe contrast mediums.1 The group of compounds that includes acetrizoate (Urokon), diprotrizoate (Miokon) and diatrizoate (Hypaque) have high solubility and relatively low toxicity.2 3 4 5 6 7 However, it has been estimated that there is a 1:500 incidence of severe reactions regardless of which of the newer compounds is used.8 Pendergrass et al.9 reported that . . .
Measurement of Renal Depth in Dynamic Renal Scintigraphy Using Ultralow-Dose CT
Authors: Yusuke Inoue, Hiroyasu Itoh, Hirokazu Tagami, Hiroki Miyatake, Yuji Asano
Journal: Clinical Nuclear Medicine (2016)

Renal depths predicted using predefined formulas are commonly used for camera-based evaluation of renal function. We investigated the feasibility and utility of renal depth measurement using ultralow-dose CT images acquired in conjunction with dynamic renal scintigraphy.Dynamic renal scintigraphy with Tc-MAG3 was performed in 117 patients (225 kidneys) using a SPECT/CT scanner, and ultralow-dose CT (estimated effective dose of 0.17 mSv) was performed during free breathing immediately before tracer injection. The clarity of the renal contour on the CT images was evaluated visually. The renal depths were measured by 2 methods and compared with depths predicted by 2 previously reported methods. The accuracy of camera-based clearance using predicted and measured depths was evaluated using a single-sample method as a standard.The clarity of the renal contour was poor in 18 of 225 kidneys, and 12 of 117 patients were considered ineligible for depth measurement. The measurement for eligible patients showed excellent intraobserver and interobserver repeatabilities. Although mean depths were similar among the 2 CT measurement methods and 2 prediction methods, absolute differences of more than 1 cm were observed in approximately 20% of kidneys between CT measurement and prediction. CT measurement of renal depth failed to improve the accuracy of camera-based clearance evaluation.Ultralow-dose CT allowed measurement of renal depth in most patients. Substantial differences in renal depth between prediction and CT measurement indicated potential usefulness of CT measurement, although no actual improvement in the accuracy of clearance estimation was demonstrated in this study.
Reply
Authors: Renato Romagnoli, Vincenzo Mazzaferro, Jordi Bruix
Journal: Hepatology (2015)

Potential conflict of interest: Dr. Mazzaferro is on the speakers' bureau for Bayer and BTG. Dr. Bruix consults for, advises for, and received grants from Bayer. He consults and advises for BTG and Novartis. He consults for and received grants from Daiichi and Arqule. He consults for Abbott, Bristol‐Myers Squibb, GlaxoSmithKline, Kowa, Lilly, and Roche. Reply: We were pleased to see the attention raised by our shared editorial1 dealing with the role of surgical resection in the treatment of hepatocellular carcinoma (HCC). However, our feeling is that Chinese colleagues somehow misunderstood our view. As a consequence, we would like to clarify on three points. First, taking inspiration from the story of the child who rescued dying fish stranded on the beach, we express our doubts concerning the final fate of those fish that were thrown back into the sea. In fact, willingness to save them in that way may just accelerate their death as grabbing may cause morbidity and mortality, crashing into the water as well and waves may eventually return them to the shore. On the contrary, producing a basin to allow fishes to survive a bit longer or just waiting for the next tide (which, in cancer, would be absence of progression or even spontaneous regression) may avoid suffering and, finally, provide better survival. Once more, we stress the concept that the most adequate strategy, defined according to acquired evidence, must be used to treat hepatocellular carcinoma (HCC). The aim is not surgical cure, but just improved survival, even if it does not come with cure. Second, in the comprehensive Table 1 of our editorial,1 we exposed the objective elements that clinicians currently take into account when selecting the best treatment for individual patients with HCC confined to the liver. In our opinion, subjective factors, such as the patient's own preference, cannot fully influence the choice made by health professionals after multidisciplinary assessment or replace the medical responsibility. Obviously, the patient's information and agreement to undergo the proposed therapy will be the following essential step before treatment application. Third, we agree with Roayaie et al.2 that hepatic resection in some selected nonideal candidates can achieve better results than guideline‐recommended treatment. However, the proper selection of nonideal patients who would benefit from surgery is an ongoing, unresolved critical issue. Therefore, although the practice of probing the territory of extended criteria for resecting HCC is currently followed by several specialized surgical teams worldwide, the time has come for prospective, less‐biased investigations in the field. We believe that now, more than ever before, hepatic surgeons and physicians should share the efforts to fulfill this task.
Genome-Wide Association Study of Bladder Cancer in a Chinese Cohort Reveals a New Susceptibility Locus at 5q12.3
Authors: Meilin Wang, Zhiqiang Li, Haiyan Chu, Qiang Lv, Dingwei Ye, Qiang Ding, Chuanliang Xu, Jianming Guo, Mulong Du, Jianhua Chen, Zhijian Song, Changjun Yin, Chao Qin, Chengyuan Gu, Yao Zhu, Guowei Xia, Fang Liu, Zhengsheng Zhang, Lin Yuan, Guangbo Fu, Zhibin Hu, Na Tong, Jiawei Shen, Ke Liu, Jielin Sun, Yinghao Sun, Jue Li, Xingwang Li, Hongbing Shen, Jianfeng Xu, Yongyong Shi, Zhengdong Zhang
Journal: Cancer Research (2016)

Genome-wide association studies (GWAS) of bladder cancer have identified a number of susceptibility loci in European populations but have yet to uncover the genetic determinants underlying bladder cancer incidence among other ethnicities. Therefore, we performed the first GWAS in a Chinese cohort comprising 3,406 cases of bladder cancer and 4,645 controls. We identified a new susceptibility locus for bladder cancer at 5q12.3, located in the intron of CWC27 (rs2042329), that was significantly associated with disease risk (OR = 1.40; P = 4.61 × 10(-11)). However, rs2042329 was not associated with bladder cancer risk in patients of European descent. The rs2042329 risk allele was also related to significantly increased expression levels of CWC27 mRNA and protein in bladder cancer tissues from Chinese patients. Additional functional analyses suggested that CWC27 played an oncogenic role in bladder cancer by inducing cell proliferation and suppressing apoptosis. In conclusion, the identification of a risk-associated locus at 5q12.3 provides new insights into the inherited susceptibility to bladder cancer in Chinese populations and may help to identify high-risk individuals. Cancer Res; 76(11); 3277-84. ©2016 AACR.
Stat Bite: Accuracy of SEER Data
Authors: E. Shambaugh
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Stat Bite: Accuracy of SEER Data Get access Evelyn Shambaugh Evelyn Shambaugh Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 19, 2 October 1991, Page 1369, https://doi.org/10.1093/jnci/83.19.1369 Published: 02 October 1991
Abstract 2505: Targeting the p53 response in pediatric B-cell acute lymphoblastic leukemia
Authors: Kathryn E. Wolak, Andrew Skol, Russell Bainer, Kenan Onel
Journal: Cancer Research (2012)

Abstract B-cell acute lymphoblastic leukemia (B-ALL) is the most common malignancy in children. Despite a cure rate of approximately 85%, the prevalence of this disease causes B-ALL to be the leading cause of cancer-related death in children. Additionally, the toxic drugs necessary for cures can cause severe side effects in developing children. Thus, there is a tremendous need for innovative therapies to combat B-ALL. The p53 tumor suppressor is a key regulator of apoptosis and is almost always wild-type in pediatric B-ALL, in stark contrast to virtually all other cancers. Alterations in the p53 pathway are associated with drug resistance, underscoring its central role in determining response to chemotherapy. We identified a set of p53-regulated transcriptional targets that comprise an apoptotic gene signature significantly associated with response to therapy and independently prognostic for outcome in pediatric ALL. We hypothesize that cells can be primed for an enhanced apoptotic response to chemotherapy by modulating expression levels of the p53-regulated apoptotic signature genes with small molecules before administering chemotherapy. We conducted a high-throughput screen to identify novel compounds that prime ALL cells for apoptosis to convert a chemotherapy-resistant cell into one that is sensitive. This screen was performed using 83,745 compounds in both the wild-type p53 cell line TK6 and the mutant-p53 line, WTK1. Cells were treated with either compound alone or compound plus daunorubicin, a drug used to treat ALL. Compounds were normalized and scored by using both the B-score and the robust Z-score. “Hits” were defined as compounds that do not significantly alter viability of the cells alone, but significantly increase daunorubicin-induced cell death. As our primary screen takes a functional approach with an endpoint of viability rather than expression of our gene signature, it's possible that compounds we have identified function through alternative mechanisms. As our secondary screen, we interrogate these hits for induction of the signature. Because patient outcome was associated with the gene signature, we hypothesize that the most successful compounds will act by altering the signature from the “bad risk” expression to the “good risk” expression, thereby having the potential to convert a chemoresistant cell into one that is sensitive. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2505. doi:1538-7445.AM2012-2505
Endoscopic ultrasound-guided placement of plastic vs. biflanged metal stents for therapy of walled-off necrosis: a retrospective single-center series
Authors: Shuntaro Mukai, Takao Itoi, Todd Baron, Atsushi Sofuni, Fumihide Itokawa, Toshio Kurihara, Takayoshi Tsuchiya, Kentaro Ishii, Shujiro Tsuji, Nobuhito Ikeuchi, Reina Tanaka, Junko Umeda, Ryosuke Tonozuka, Mitsuyoshi Honjo, Takuji Gotoda, Fuminori Moriyasu, Ichiro Yasuda
Journal: Endoscopy (2014)

<b>Background and study aims:</b> Recently, a novel fully covered and biflanged metal stent (BFMS) dedicated to the drainage of walled-off necrosis (WON) was developed. The aim of this study was to retrospectively evaluate the safety, efficacy, and cost performance of drainage of WON using the novel BFMS compared with a traditional plastic stent. <b>Patients and methods:</b> A total of 70 patients with symptomatic WON were treated under endoscopic ultrasound (EUS) guidance. Initial drainage was conducted using the single gateway technique with placement of one or more plastic stents or a single BFMS. If drainage was unsuccessful, direct endoscopic necrosectomy (DEN) was performed. <b>Results:</b> There were no statistically significant differences in rates of technical success, clinical success, and adverse events between plastics stents and BFMS, despite the size of WON in the BFMS group being significantly larger than that in the plastic stent group (105.6 vs. 77.1 mm; <i>P</i> = 0.003). The mean procedure times for the first EUS-guided drainage and for re-intervention were significantly shorter in the BFMS group than in the plastic stent group (28.8 ± 7.1 vs. 42.6 ± 14.2, respectively, for drainage, <i>P</i> < 0.001; and 34.9 ± 8.5 vs. 41.8 ± 7.6, respectively, for re-intervention, <i>P</i> < 0.001). There was no statistically significant difference in the total cost between plastic stent and BFMS use in the treatment of WON ($ 5352 vs. $ 6274; <i>P</i> = 0.25). <b>Conclusions:</b> Plastic stents and BFMS were safe and effective for the treatment of WON. In particular, BFMS placement appeared to be preferable for initial EUS-guided drainage and additional re-intervention (e. g. DEN) as it reduced the procedure time. Prospective randomized controlled trials are warranted.