tbuckley/cabot-search huggingface dataset:
Immune status and immune recovery in children with lymphoma at the end of therapy (chemotherapy and/or radiotherapy) and in follow-up evaluations
Authors: S. P. Kosmidis, A. Pourtsidis, D. Bouhoutsou, M. Baka, M. Varvoutsi, D. Doganis, N. Douladiris, M. Synodinou, F. Saxoni-Papageorgiou, H. Kosmidis
Journal: Journal of Clinical Oncology (2008)

21002 Background and Methods: Humoral and cellular immunity were prospectively evaluated in 22 children with lymphoma (11 with Hodgkin's-HD- and 11 with non Hodgkin's -NHL-) at the completion of therapy and every 6 months thereafter. In addition children with HD were evaluated before and after radiotherapy. Results: Immunoglobulin levels were normal prior to the onset of therapy in all but one child. At the end of therapy immunoglobulin levels decreased: IgM in 18, IgG in 12 and IgA in 7 children. In addition 17/22 had decreased CD19 levels. In HD after RT IgG and CD19 increased significantly, p=0.013 and p=0.004 respectively. IgM levels remained abnormally low in 16/22 children up to 18 months post therapy completion. At the end of therapy, helpers T lymphocytes (CD 4) were low in 20/22 and suppressors (CD8) were elevated in 13/22. (In HD prior to RT CD8 were high in 10/11 and CD4 were low in 6/11). Suppressors CD8 remained elevated in 12/20 and helpers CD4 remained abnormally low in 18/20 for a period of 6–18 months post therapy. Immunized children became non immune in polio (15/22), in mumps 6/22, in rubella 5/22 and in measles (1/22). Conclusions: In children with lymphoma IgM remains low for long period. Helpers T lymphocytes are low and suppressors are high at the end of therapy. Suppressors cells normalize faster whereas helpers remain abnormally low for long period. Most children become non immune to polio whereas the majority have antibodies to MMR. Despite depressed immunity, serious infections were not documented. No significant financial relationships to disclose.
Protective mitochondrial transfer from bone marrow stromal cells to acute myeloid leukemic cells during chemotherapy
Authors: Ruxanda Moschoi, Véronique Imbert, Marielle Nebout, Johanna Chiche, Didier Mary, Thomas Prebet, Estelle Saland, Rémy Castellano, Laurent Pouyet, Yves Collette, Norbert Vey, Christian Chabannon, Christian Recher, Jean-Emmanuel Sarry, Damien Alcor, Jean-François Peyron, Emmanuel Griessinger
Journal: Blood (2016)
Extensively drug-resistant tuberculosis: first report of a case in Ireland
Authors: B Kennedy, O Lyons, A-M McLoughlin, N Gibbons, D O'Flanagan, J Keane
Journal: Eurosurveillance (2008)

Extensively drug-resistant tuberculosis (XDR-TB) is an emerging global threat. Between 2002 and 2007 sixteen countries in the European Union (EU) reported at least one case of XDR-TB [1]. Infection is characterised by alarming mortality rates in both HIV and non-HIV populations.
UK science research agenda should be set by stronger single agency, review recommends
Authors: I. Torjesen
Journal: BMJ (2015)

A government commissioned review of UK research councils has called for a more formal role for the councils’ partnership organisation to streamline administration and provide a more united voice in promoting science research to the government.1

Paul Nurse, a geneticist and head of the Francis Crick Institute in London, who led the review, said that the seven research councils provided high quality leadership in their respective disciplines and that they should continue to manage their individual research budgets, which total around £3bn a year. He was speaking at a press conference on 19 November.

But the Research Councils UK partnership should evolve into a more …
PTU-022 atisfaction with healthcare in outpatients with gastrointestinal diseases: validation of a survey instrument and influence of patient characteristics
Authors: K Anim-Somuah, F Brailsford, C Luces, K Bodger
Journal: Gut (2010)

<h3>Introduction</h3> The Next Stage Review (“Darzi Report”) for the UK NHS puts emphasis on measuring patient experience and Patient Reported Outcome Measures (PROMS). Measures of patient satisfaction with healthcare (SwH) are controversial and well-validated instruments are lacking for use in gastroenterology clinics. <h3>Methods</h3> We developed a multi-item questionnaire incorporating demographic and socioeconomic variables, a rating of global heath state (EQ5D), a locally-validated SwH score (VAS: 0–100) and satisfaction ratings (VAS) for 13 aspects of the service. This was administered to consecutive patients attending GI clinics at our University hospital. Patient factors associated with variation in global SwH scores were identified by univariate and multivariate methods and we explored correlations between global satisfaction rating and subscores for individual aspects of the service. <h3>Results</h3> 151 respondents to date (Males: 36%; mean age: 54.6 years; education to degree level: 23.8%; mean global health (EQ5D VAS): 69.4; mean global SwH: 87.6 (range 10–100)). Mean SwH scores were lower in females (84.5 vs 91.8, p=0.004) and those with degree level education (82.6 vs 90.0, p=0.02). SwH was positively correlated with global health score (EQ5D-VAS: Pearson r=0.29, p=0.01) and negatively with pain score (EQ5D pain domain: r=−0.29, p=0.001). Global SwH score was positively correlated with VAS ratings for: “need to attend clinic today” (r=0.44), “seen often enough” (r=0.49), “administrative service” (r=0.47), “waiting time in clinic” (r=0.49), “time spent with doctor” (r=0.68), “doctors explanation” (r=0.70), “doctors understanding of health problem” (r=0.62), “doctors professionalism” (r=0.60), “nurse professionalism” (r=0.58), “waiting time to next visit” (r=0.48), “waiting times for tests” (r=0.51), “overall clinic care” (r=0.77) and “overall hospital care” (r=0.56). No correlation with age. <h3>Conclusion</h3> Our simple instrument for measuring global score for satisfaction for clinic services shows good face validity when compared with ratings for individual aspects of the service. Doctor-related variables were most strongly correlated with global scores. However, global patient-scores are influenced by current state of health, pain and demographic/social variables. Instruments for measuring service-user satisfaction require careful development and interpretation.
Brief Communication: Intramitochondrial Bodies in a Human Cell Line Carrying Oncornavirus-Like Particles2
Authors: Jafa Keydar, Gary Braslawsky, Tamar Dajbog, Shulamith Karby, Sidney T. Shinedling, Fannie Weiss, Jacob Delarea
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Brief Communication: Intramitochondrial Bodies in a Human Cell Line Carrying Oncornavirus-Like Particles Get access Jafa Keydar, Jafa Keydar Search for other works by this author on: Oxford Academic PubMed Google Scholar Gary Braslawsky, Gary Braslawsky Search for other works by this author on: Oxford Academic PubMed Google Scholar Tamar Dajbog, Tamar Dajbog Search for other works by this author on: Oxford Academic PubMed Google Scholar Shulamith Karby, Shulamith Karby Search for other works by this author on: Oxford Academic PubMed Google Scholar Sidney T. Shinedling, Sidney T. Shinedling Search for other works by this author on: Oxford Academic PubMed Google Scholar Fannie Weiss, Fannie Weiss Search for other works by this author on: Oxford Academic PubMed Google Scholar Jacob Delarea Jacob Delarea Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 1, January 1975, Pages 247–249, https://doi.org/10.1093/jnci/54.1.247 Published: 01 January 1975 Article history Received: 05 July 1974 Accepted: 27 September 1974 Published: 01 January 1975
Bioethics Bibliography
Authors: LEROY WALTERS
Journal: Annals of Internal Medicine (1976)

Comments1 September 1976Bioethics BibliographyLEROY WALTERS, PH.D.LEROY WALTERS, PH.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-85-3-397_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Your April editorial note, "Finding the Other Literature of Medicine" (Ann Intern Med 84:488-489, 1976), has recently come to my attention. I thought that your readers might like to have information concerning additional reference sources in the field of medical ethics.For the past 2 years the National Library of Medicine has supported the development of a comprehensive information-retrieval system for the field of biomedical ethics (or bioethics) at the Kennedy Institute, Georgetown University. My colleagues and I have created an index language for the field that is closely coordinated with MeSH; in addition, we have published... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: LEROY WALTERS, PH.D.Affiliations: Center for Bioethics Kennedy Institute for the Study of Human Reproduction and Bioethics Georgetown University Washington, D.C. 20057 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byEthics & Values in the Biology Classroom 1 September 1976Volume 85, Issue 3Page: 397-397KeywordsBioethicsInformation technologyLibrariesMedical ethics ePublished: 1 December 2008 Issue Published: 1 September 1976 PDF downloadLoading ...
Dexamethasone suppression test and clinical outcome in prepubertal depressed children
Authors: E B Weller, R A Weller, M A Fristad, M L Cantwell, S H Preskorn
Journal: American Journal of Psychiatry (1986)

Hospitalized prepubertal depressed children with abnormal dexamethasone suppression test (DST) results were treated and given repeat DSTs at 6 weeks (N = 21) and 5 months (N = 14). DST results were significantly correlated with clinical status at 5 months but not at 6 weeks.
PWE-146 The impact of body mass index on gastrectomy in western patients:a meta-analysis
Authors: F Puccetti, A Chaudry, A Venerus, W Allum
Journal: Gut (2015)

<h3>Introduction</h3> Although the impact of BMI on postoperative outcomes after curative resection for gastric cancer has been assessed in many different studies worldwide there have been conflicting conclusions. This may be due to the heterogeneity of study populations and geographical location may be a confounding factor due to a lack of international consensus regarding multimodal treatment. The aim of this meta-analysis was to specifically evaluate western cohort studies concerning the influence of preoperative BMI on surgical and oncological outcomes after gastric resectional surgery for adenocarcinomas. <h3>Method</h3> Between December 2014 and January 2015 a comprehensive electronic search was performed to identify western publications relating to BMI and outcomes following resectional surgery for gastric cancer. Articles that did not report preoperative BMI, post-oesophagectomy morbidity, early mortality and 5 years overall survival were excluded. The search was performed using the Pubmed search engine and the reference lists for each of the articles included was also reviewed in order to find any additional studies. A statistical analyses were performed using OpenMetaAnalyst software (Version 10.10). <h3>Results</h3> Three hundred and fifteen records deriving from the electronic search were examined, 7 western publications were included with a total of 4535 patients. The Meta-analysis study population was stratified in groups according to preoperative BMI: 2535 patients with BMI &lt; 25 kg/m<sup>2</sup>and 2003 patients with BMI &gt; 25 kg/m<sup>2</sup>. A raised BMI was strongly associated with a 35–40% increase in the risk of postoperative complications such as anastomotic leakages and wound infections rates (p-value: 0.006 and 0.016 respectively). Although the difference did not reach statistical significance, BMI &gt; 25 was also associated with abdominal infections (28% with a p-value of 0,237), bleeding (32% and 0,075), pulmonary (30% and 0.077), cardiac complications rate (33% and 0,222). Furthermore, neither the risk of Early mortality nor 5 years Overall Survival were affected by difference in BMI. <h3>Conclusion</h3> This meta-analysis demonstrates that in western series a raised BMI is associated with an increase in morbidity, namely anastomotic leakages and wound infections rates but this did not translate into early mortality or a reduction in long term survival. Whilst a raised BMI should not preclude multimodal treatment including surgical resection in Western patients, we would suggest it is important to mitigate risk by careful preoperative planning, optimisation and a low index of suspicion for anastomotic leakage postoperatively. The increased risk of postoperative morbidity also has resource implications and further studies are required to analysed the cost-effectiveness of gastric surgery in high BMI patients. <h3>Disclosure of interest</h3> None Declared.
How to follow-up patients with hereditary haemorrhagic telangiectasia and suspected pulmonary arteriovenous malformations
Authors: Thierry Chinet
Journal: European Respiratory Journal (2016)

Pulmonary arteriovenous malformations (PAVMs) are abnormal vascular structures that connect one or several pulmonary arteries to one or several pulmonary veins without interposition of a capillary bed, resulting in a right-to-left shunt (RLS) [1]. Over 80% of PAVMs are associated with the genetic disease hereditary haemorrhagic telangiectasia (HHT). The vascular malformations predispose patients to severe complications due to paradoxical systemic emboli of thrombotic or septic origin, such as stroke and brain abscess [2–5]. The treatment of choice for PAVMs is transcatheter embolotherapy, although concerns are emerging regarding the long-term consequences of this procedure, especially in children [6]. Contrast echocardiography is useful for the follow-up of HHT patients with pulmonary arteriovenous malformations <http://ow.ly/YNql5>
Psychiatric disturbances associated with Erhard Seminars Training: II. additional cases and theoretical considerations
Authors: M A Kirsch, L L Glass
Journal: American Journal of Psychiatry (1977)

In a previous article, the authors reported on 5 individuals who developed psychoses after participation in Erhard Seminars Training (est). Two additional cases are reported, and the combined case material is discussed in terms of group and psychodynamic theories. The authoritarian est leadership style may mobilize in trainees an overdetermined and pathological reliance on identification with the aggressor. Such a mechanism may be central to the production of psychiatric casualties, particularly in individuals with defective ego boundaries. Future controlled research is necessary to ascertain the rate of occurrence of psychiatric disturbances associated with est and to test the authors' hypotheses.
The Potential for Postrandomization Confounding in Randomized Clinical Trials
Authors: JoAnn E. Manson, Chrisandra L. Shufelt, James M. Robins
Journal: JAMA (2016)

In this Viewpoint, JoAnn Manson and colleagues discuss the risk of postrandomization "confounding," a bias that can be introduced in long-duration trials of sustained interventions, using statin initiation after randomization in Women's Health Initiative trials as an example.
FRI0307 Bone Mineral Density, Spinal Micro-Architecture (TBS Data) and Body Composition in the Older Ukrainian Women with Vertebral Fragility Fractures
Authors: V. Povoroznyuk, N. Dzerovych, R. Povoroznyuk
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteoporosis and sarcopenia are the most frequent musculoskeletal disorders affecting older people. Fracture incidence as well as the number of fractures increase due to the population9s ageing. Recent studies show that a low skeletal muscle mass is associated with the poor structural bone parameters and impaired balance of the elderly people. <h3>Objectives</h3> The aim of this study is to evaluate the bone mineral density (BMD), trabecular bone score (TBS) and body composition in women taking into account the presence of vertebral fragility fractures (VFF). <h3>Methods</h3> We9ve examined 171 women aged 65-89 years (mean age – 73.12±0.39 yrs; mean height – 1.58±0.004 m; mean weight – 72.54±0.99 kg). The patients were divided into the groups depending on the VFF presence: A – no VFF (n=105; mean age – 72.70±0.54 yrs; mean height – 1.58±0.006 m; mean weight – 74.43±1.33 kg), B – present VFF (n=66; mean age – 73.79±0.55 yrs; mean height – 1.58±0.008 m; mean weight – 69.53±1.37 kg). Total body, lumbar spine, femoral neck, forearm BMD, lateral vertebral assessment, trabecular bone score (L1-L4), lean and masses were measured by DXA densitometer (Prodigy, GE). Appendicular skeletal mass (ASM) was measured at all the four limbs with DXA. We9ve also calculated the appendicular skeletal mass index (ASMI) according to the formula ASM/height<sup>2</sup> (kg/m<sup>2</sup>). <h3>Results</h3> We have found the following parameters to be significantly lower in women with the VFF compared to women having no VFF: BMD of total body (A – 0.859±0.01 g/cm<sup>2</sup>, B – 0.764±0.02 g/cm<sup>2</sup>; p&lt;0.05), spine (A – 1.038±0.02 g/cm<sup>2</sup>, B – 0.927±0.03 g/cm<sup>2</sup>; p&lt;0.05), femoral neck (A – 0.787±0.01 g/cm<sup>2</sup>, B – 0.711±0.01 g/cm<sup>2</sup>; p&lt;0.05), 33% forearm (A – 0.690±0.01 g/cm<sup>2</sup>, B – 0.600±0.01 g/cm<sup>2</sup>; p&lt;0.05), TBS (A – 1.171±0.01, B – 1.116±0.02; p&lt;0.05), whole-body fat mass (A – 30736.87±939.92 g, B – 25877.45±966.90 g; p&lt;0.05), whole-body lean mass (A – 41202.44±498.18 g, B – 39440.77±594.78 g; p&lt;0.05), ASM (A – 16.47±0.22 kg, B – 15.81±0.22 kg; p&lt;0.05) and ASMI (A – 6.59±0.07 kg/m<sup>2</sup>, B – 6.34±0.09 kg/m<sup>2</sup>; p&lt;0.05). The frequency of sarcopenia was 2% in women with no VFF and 14% - in women with the VFF. <h3>Conclusions</h3> Women with the VFF have the BMD, TBS, lean and fat masses data significantly lower in comparison to women with no VFF. <h3>Disclosure of Interest</h3> None declared
Chemotherapy in inflammatory breast cancer.
Authors: A E Denes
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.5.825 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3572468 Chemotherapy in inflammatory breast cancer. A E DenesxA E DenesSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.5.825 PDF "Chemotherapy in inflammatory breast cancer.." Journal of Clinical Oncology, 5(5), p. 825© 1987 by American Society of Clinical Oncology
Abstract 12729: Comparisons of Peak LDL-C Reduction and Duration of Effect With Lower or Higher Dosing Regimens of the PCSK9 Inhibitor Evolocumab
Authors: Michael J Koren, Sameer Doshi, Rita Castro, John P Gibbs, Maurice G Emery, Ransi Somaratne, Scott M Wasserman
Journal: Circulation (2015)

Introduction: Recent studies of anti-PCSK9 antibodies have established this new class as highly effective in lowering LDL-C and well tolerated with or without background statins. Because peak LDL-C responses to anti-PCSK9 antibodies are not linearly dose-proportional, understanding the pharmacodynamic profile of the therapy can help select optimal dosing. Consequently, we assessed the peak LDL-C effects of 3 evolocumab doses during ongoing therapy and the persistence of effects after 2 weeks when the next dose would be due. Methods: In the 12 week Phase 2 LAPLACE-TIMI 57 study 107 patients underwent assessments at weeks 9 and 11 in addition to the usual biweekly lipid measurements at weeks 8 and 10. We analyzed data from patients who received evolocumab 70 or 140 mg Q2W or 420 mg QM for PCSK9 suppression and peak LDL-C effectiveness estimated to occur 1 week post dosing. Persistence of the LDL-C lowering effect over the next week was also assessed. Results: The Figure shows PCSK9 and LDL-C over the analyzed interval. Mean baseline LDL-C in these groups was about 130 mg/dL. Week 8 LDL-C representing steady state trough effects were 85.4 mg/dL (35% below baseline), 47.1 mg/dL (62% below baseline) and 52.8 mg/dL (52% below baseline) for 70 and 140 mg Q2W and 420 mg QM, respectively. Week 9 LDL-C for the 70 and 140 mg doses reflected reductions from baseline of 55% and 70%, respectively and an additional -29% and -22% from trough levels. The offset from maximum LDL-C lowering at week 9 to week 10 for Q2W regimens showed mean LDL-C increases of 25.4 mg/dL in the 70 mg group and 6.3 mg/dL in the 140 mg group. No offset was seen in the 420 mg group during weeks 9-10. LDL-C variability was greatest for 70 mg Q2W over the studied dosing interval. Conclusions: During steady state dosing of evolocumab on stable statin therapy, dose escalations affect the duration of the LDL-C lowering response more than the peak effect. Higher doses result in less fluctuation in LDL-C response, which may be a goal of therapy.
AB1000 Acute Osteoarticular Infections in Children in a Tertiary Hospital: Our Experience Across 5 Years
Authors: P. Sánchez-Moreno, A.V. Ardanuy-Pizarro, L. Navarro, M. Melόn, M.D. Falcόn-Neyra, M. Camacho-Lovillo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Acute osteoarticular infections (AOI) are potentially severe disease. A consensus document about them has been recently published in our country. The aim of this study was to evaluate the epidemiology, etiology, diagnostic approach and treatment of AOI in our hospital. <h3>Methods</h3> Retrospective descriptive study of children (&lt;14 years) with AOI attended from January 2009 to June 2014 at a tertiary hospital. <h3>Results</h3> 117 cases were reviewed. 78 cases (66.6%) were septic arthritis (SA), 25 cases (21.3%) were osteomyelitis (OM) and 14 (11.9%) osteoarthritis (OA). SA was most frequent in females (54%) whereas OM in males (60%). Median age at diagnostic was higher in OM (47 vs 31 months in SA). Fever was less common in SA (79% vs 84% in OM). Pain was the most frequent symptom in OM (68%) and swelling in SA (41%). Previous risk factors were found more frequently in SA (51% vs 36% in OM), being the most common trauma, and highlighting the common cold in SA. Knee was the most common location (59%) in SA whereas femur and tarsus (both 32%) in MO. Median CRP on admission was 49,7 mg/L in SA and 56,2mg/L in OM. Initial ESR determination was uncommon (13%). Conventional X-Ray were performed in a significant percentage of patients, having low yield for both diagnosis. 92% of US performed in SA were compatible against 75% of the OM. MRI and bone scintigraphy had the highest yield for SA and OM diagnosis (100%). MRI was done in 88% of OM vs 15% of SA whereas scintigraphy was done in 88% of OM vs 7% of SA. Arthrocentesis was performed in 77% of SA, joint fluid was obtained in 73% and 24.5% of fluid cultures were positive. Blood culture was conducted in 71% of patients (36% positive in SA; 32% in OM). S. Aureus was the most frequent bacteria isolated in joint fluid and blood cultures. All the patients were admitted. Most children received intravenous antibiotic treatment with cefotaxime and cloxacillin, for a median of 10.45 (±5) days for OM and 7.7 (±4.5) days for SA. Cefadroxile was the most common oral antibiotic (85%). Total treatment duration was 27 (±16) days for OM and 26.1 (±16) days for SA. 16% of children with OM and 27% with SA underwent surgery. Only 5% of SA had complications or sequels. <h3>Conclusions</h3> The characteristics of our patients were similar to those published to date. Understanding the epidemiology, etiology and therapeutic approach of our series will allow us to compare it with those of a prospective multicenter study that will be developed following the national consensus publication. <h3>References</h3> Saavedra-Lozano J, et al. An Pediatr (Barc). 2014. Gutierrez K. Osteomyelitis. 4th ed. Philadelphia: Churchill Livingstone; 2012. p. 469-77 and 77-83. Paakkonen M. Pediatr Clin North Am. 2013;60:425-36. <h3>Disclosure of Interest</h3> None declared