tbuckley/cabot-search huggingface dataset:
AB0293 High Serum Levels of Anti-Cyclic Citrullinated Peptide Antibody and Matrix Metalloproteinase-3 at the Time of Diagnosis of Rheumatoid Arthritis Are Possible Predictors of Future Initiation of Biological Agents
Authors: M. Kono, T. Odani, K. Hiura, S. Fukaya, K. Oba, T. Takeda, H. Kikuchi, S. Iwaki-Egawa, T. Atsumi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Damage to bones is accelerated massively during the first two years after developing rheumatoid arthritis (RA), thus the patients with poor response to csDMARDs need early intervention by biological agents (Bio). However, few markers have been established for the prediction of future use of Bio on the diagnosis as RA. <h3>Objectives</h3> To clarify the predictors of future initiation of Bio at the time of RA diagnosis. <h3>Methods</h3> One hundred five consecutive new outpatients complaining arthralgia without definite diagnosis of RA were included at 3rd Department of Internal medicine clinic at Hokkaido P.W.F.A.C Obihiro-Kosei General Hospital from December 2012 to September 2013. The subjects classified as RA, fulfilling the criteria of 2010 American College of Rheumatology/European League Against Rheumatism, were treated by standard protocol and followed until December 2014 to discriminate Bio user from non-Bio user. The observation period until the initiation of Bio was registered. <h3>Results</h3> Among 105 patients, 49 were classified as having RA by the criteria. Out of 49 patients, four patients were excluded due to their ineligibility (two patients on prednisone at the time of RA diagnosis, one on over 20 mg/day prednisone due to interstitial lung disease during observation period, and one with less than three months9 observation period). At the time of RA diagnosis, mean age was 60±15 years old and the median disease duration was 20 (range: 3.5-24.8) months. Mean Disease Activity Score 28-ESR was 5.0±1.3, median simplified disease activity index 17.1 (5.7-71.9), anti-cyclic citrullinated peptide antibody (ACPA) 42 (0.6-500) U/ml, rheumatoid factor 67 (4-1580) mg/dl, matrix metalloproteinase-3 (MMP-3) 80 (24-1515) ng/ml, and CRP 0.45 (0.01-10.47) mg/dl. During observation period, 14 patients were initiated Bio. Multivariate analysis with Cox9s proportional hazards model showed that ACPA (HR for every 50 U/ml, 1.26, 95%C.I. 1.05-1.50, p=0.01) and MMP-3 (HR for every 50 ng/ml, 1.15, 95%C.I. 1.01-1.30, p=0.03) are statistically significant risk factors for Bio users. We determined cutoff points of ACPA and MMP-3 using the receiver operatorating characteristic curves and we decided ACPA ≥250 U/ml and MMP-3 ≥200 ng/ml were risk factors. Log-rank test showed the more risk factors the patients have, the higher risk for initiation of Bio (Figure 1, p&lt;0.001). <h3>Conclusions</h3> High serum levels of ACPA and MMP-3 at the time of diagnosis of RA are possible predictors of future Bio user. <h3>Disclosure of Interest</h3> None declared
Ascaris lumbricoides causing obscure gastrointestinal bleeding detected by double-balloon enteroscopy
Authors: Benjamin Walter, Peter Born, Jürgen Winker
Journal: Endoscopy (2015)

A 79-year-old male patient was referred to hospital for investigation of microcytic hypochromic anemia. His previous medical history included coronary heart disease, cardiac insufficiency, chronic renal failure, percutaneous aortic valve replacement, and chronic atrial fibrillation with phenprocoumon as regular medication. He reported episodes of fatigue, no alteration of stools or stool color, and no other complaints. Physical examination showed unremarkable findings. Laboratory investigation showed microcytic anemia (hemoglobin 8.2 mg/dL). Upper and lower endoscopy showed no relevant abnormalities, but a large amount of blood was evacuated from the terminal ileum. Capsule endoscopy was performed and revealed a bleeding source in the middle jejunal region and a foreign body, suspected of possibly being part of a nasogastric tube ([Fig. 1]).
OP07 Macrophage cell therapy causes the hepatic recruitment of host effector cells and improves structure and function in a murine model of chronic liver disease
Authors: J Thomas, D Wojtacha, C Pope, T Gordon-Walker, A Robson, S Hartland, P Ramachandran, J Iredale, S Forbes
Journal: Gut (2010)

Introduction  Bone marrow (BM) cell populations have a number of roles in the development and resolution of chronic liver disease. Clinical trials of BM cell therapy have already begun. These have generally employed mixed cell populations often enriched for adult stem cells. Such cells may have a range of phenotypically diverse progeny. The identification of a defined cell type with beneficial effect will provide the basis of rational and predictable therapy. We have previously shown that macrophages are key mediators of scar remodelling. Iterative injury with carbon tetrachloride (CCl4) results in a well characterised model of murine hepatic fibrosis.  Aim  We sought to determine whether bone marrow derived macrophages (BMMs) could be used as cell therapy for liver fibrosis.  Method  Liver fibrosis was induced in female C57/Bl6 mice by 12 weeks i.p. carbon tetrachloride (CCl4). Macrophages were derived from the bone marrow of age-matched syngeneic mice cultured for 7 days under low adherence conditions in macrophage colony stimulating factor conditioned media. 8 weeks into the CCl4 injury protocol, mice received either 106 BMMs via the hepatic portal vein (n=8) or control medium (n=8). Serum was analysed for albumin and livers were analysed for mediators of inflammation, fibrosis and regeneration. To track donor cells, male (C57Bl/6) or transgenic green fluorescent protein+ (CBA) BMMs were delivered to strain-matched fibrotic wild type mice.  Results  BMMs were 88% F4/80+/CD11b+, possessed characteristic morphologic and phenotypic features, and expressed the chemokines MCP-1, MIP-1α and MIP-2. At 12 weeks, C57Bl/6 mice receiving the macrophage injection had 32% less fibrosis (mean±SEM: 2.5±0.4 vs 3.7±0.3%, p  Conclusion  BMM therapy decreases fibrosis and increases regeneration improving clinically meaningful parameters of chronic liver disease in this model. The actions of the donor BMMs are amplified through paracrine signalling to numerically greater endogenous cell populations. Importantly, these effects are mediated by a single differentiated donor cell type, bringing clarity to the cause-effect relationship.
Predictors of portal vein system thrombosis after laparoscopic splenectomy and azygoportal disconnection: A Retrospective Cohort Study of 75 Consecutive Patients with 3-months follow-up
Authors: Guo-Qing Jiang, Dou-Sheng Bai, Ping Chen, Bing-Lan Xia, Jian-Jun Qian, Sheng-Jie Jin
Journal: International Journal of Surgery (2016)
Altered breathing mechanics and ventilatory response during exercise in children born extremely preterm
Authors: J E MacLean, K DeHaan, D Fuhr, S Hariharan, B Kamstra, L Hendson, I Adatia, C Majaesic, A T Lovering, R B Thompson, D Nicholas, B Thebaud, M K Stickland
Journal: Thorax (2016)

Extreme preterm birth confers risk of long-term impairments in lung function and exercise capacity. There are limited data on the factors contributing to exercise limitation following extreme preterm birth. This study examined respiratory mechanics and ventilatory response during exercise in a large cohort of children born extremely preterm (EP).This cohort study included children 8-12 years of age who were born EP (≤28 weeks gestation) between 1997 and 2004 and treated in a large regionalised neonatal intensive care unit in western Canada. EP children were divided into no/mild bronchopulmonary dysplasia (BPD) (ie, supplementary oxygen or ventilation ceased before 36 weeks gestational age; n=53) and moderate/severe BPD (ie, continued supplementary oxygen or ventilation at 36 weeks gestational age; n=50). Age-matched control children (n=65) were born at full term. All children attempted lung function and cardiopulmonary exercise testing measurements.Compared with control children, EP children had lower airway flows and diffusion capacity but preserved total lung capacity. Children with moderate/severe BPD had evidence of gas trapping relative to other groups. The mean difference in exercise capacity (as measured by oxygen uptake (VO2)% predicted) in children with moderate/severe BPD was -18±5% and -14±5.0% below children with no/mild BPD and control children, respectively. Children with moderate/severe BPD demonstrated a potentiated ventilatory response and greater prevalence of expiratory flow limitation during exercise compared with other groups. Resting lung function did not correlate with exercise capacity.Expiratory flow limitation and an exaggerated ventilatory response contribute to respiratory limitation to exercise in children born EP with moderate/severe BPD.
Value of Ethanol Gelation Test
Authors: D Gitlin
Journal: New England Journal of Medicine (1971)

New information on alpha fetoprotein (AFP) sites of synthesis are presented in this letter to the editor. Traces of AFP were synthesized by not only the human yolk sac and liver but also, in 6/9 human embryos and fetuses studied, by the gastrointestinal tract. Also, sharks synthesize an AFP similar to that of the human in molecular size and electrophoretic mobility. Although small amounts of AFP are synthesized by sharks in the liver, the greatest site of synthesis is actually the stomach, with smaller amounts synthesized in the intestinal mucosa; no synthesis was observed in the shark yolk sac. Thus it appears that early in evolution the site of synthesis of AFP was mainly in the gastrointestinal tract and that during evolution 2 outgrowths of the entoderm (the liver and yolk sac) became the major sites of AFP synthesis; in birds the synthesis seems to be restricted to the yolk sac, with only traces found in the gastrointestinal tract.
Evidence-Based Algorithms Using High-Sensitivity Cardiac Troponin in the Emergency Department
Authors: David A. Morrow
Journal: JAMA Cardiology (2016)

Johannes Tobias Neumann, MD; Nils Arne Sörensen, MD; Tjark Schwemer, MD; Francisco Ojeda, PhD; Rafael Bourry; Vanessa Sciacca; Sarina Schaefer, MD; Christoph Waldeyer, MD; Christoph Sinning, MD; Thomas Renné, MD; Martin Than, MD; William Parsonage, MD; Karin Wildi, MD; Nataliya Makarova, MSc; Renate B. Schnabel, MD; Ulf Landmesser, MD; Christian Mueller, MD; Louise Cullen, MD; Jaimi Greenslade, MD; Tanja Zeller, PhD; Stefan Blankenberg, MD; Mahir Karakas, MD; Dirk Westermann, MD
IDH mutant gliomas escape natural killer cell immune surveillance by downregulation of NKG2D ligand expression
Authors: Xiaoran Zhang, Aparana Rao, Paola Sette, Christopher Deibert, Alexander Pomerantz, Wi Jin Kim, Gary Kohanbash, Yigang Chang, Yongseok Park, Johnathan Engh, Jaehyuk Choi, Timothy Chan, Hideho Okada, Michael Lotze, Paola Grandi, Nduka Amankulor
Journal: Neuro-Oncology (2016)

Diffuse gliomas are poorly immunogenic, fatal brain tumors. The basis for insufficient antitumor immunity in diffuse gliomas is unknown. Gain-of-function mutations in isocitrate dehydrogenases (IDH1 and IDH2) promote diffuse glioma formation through epigenetic reprogramming of a number of genes, including immune-related genes. Here, we identify epigenetic dysregulation of natural killer (NK) cell ligand genes as significant contributors to immune escape in glioma. We analyzed the database of The Cancer Genome Atlas for immune gene expression patterns in IDH mutant or wild-type gliomas and identified differentially expressed immune genes. NKG2D ligand expression levels and NK cell–mediated lysis were measured in IDH mutant and wild-type patient-derived glioma stem cells and genetically engineered astrocytes. Finally, we assessed the impact of hypomethylating agent 5-aza-2′deoxycytodine (decitabine) as a potential NK cell sensitizing agent in IDH mutant cells. IDH mutant glioma stemlike cell lines exhibited significantly lower expression of NKG2D ligands compared with IDH wild-type cells. Consistent with these findings, IDH mutant glioma cells and astrocytes are resistant to NK cell–mediated lysis. Decitabine increases NKG2D ligand expression and restores NK-mediated lysis of IDH mutant cells in an NKG2D-dependent manner. IDH mutant glioma cells acquire resistance to NK cells through epigenetic silencing of NKG2D ligands ULBP1 and ULBP3. Decitabine-mediated hypomethylation restores ULBP1 and ULBP3 expression in IDH mutant glioma cells and may provide a clinically useful method to sensitize IDH mutant gliomas to NK cell–mediated immune surveillance in patients with IDH mutated diffuse gliomas.
Human T cell responses to Japanese encephalitis virus in health and disease
Authors: Lance Turtle, Tanushka Bali, Gemma Buxton, Savita Chib, Sajesh Chan, Mohammed Soni, Mohammed Hussain, Heather Isenman, Prachi Fadnis, Manjunatha M. Venkataswamy, Vishali Satishkumar, Penny Lewthwaite, Ayako Kurioka, Srinivasa Krishna, M. Veera Shankar, Riyaz Ahmed, Ashia Begum, Vasanthapuram Ravi, Anita Desai, Sutee Yoksan, Stefan Fernandez, Christian B. Willberg, Henrik N. Kloverpris, Christopher Conlon, Paul Klenerman, Vijaya Satchidanandam, Tom Solomon
Journal: The Journal of Experimental Medicine (2016)

Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue virus (DENV) cocirculates in many JEV-endemic areas, and clinical data suggest cross-protection between DENV and JEV. To address the role of T cell responses in protection against JEV, we conducted the first full-breadth analysis of the human memory T cell response using a synthetic peptide library. Ex vivo interferon-γ (IFN-γ) responses to JEV in healthy JEV-exposed donors were mostly CD8+ and targeted nonstructural (NS) proteins, whereas IFN-γ responses in recovered JE patients were mostly CD4+ and targeted structural proteins and the secreted protein NS1. Among patients, a high quality, polyfunctional CD4+ T cell response was associated with complete recovery from JE. T cell responses from healthy donors showed a high degree of cross-reactivity to DENV that was less apparent in recovered JE patients despite equal exposure. These data reveal divergent functional CD4+ and CD8+ T cell responses linked to different clinical outcomes of JEV infection, associated with distinct targeting and broad flavivirus cross-reactivity including epitopes from DENV, West Nile, and Zika virus.
The definition, diagnostic testing, and management of chronic inducible urticarias - The EAACI/GA<sup>2</sup>LEN/EDF/UNEV consensus recommendations 2016 update and revision
Authors: M. Magerl, S. Altrichter, E. Borzova, A. Giménez-Arnau, C. E. H. Grattan, F. Lawlor, P. Mathelier-Fusade, R. Y. Meshkova, T. Zuberbier, M. Metz, M. Maurer
Journal: Allergy (2016)

These recommendations for the definition, diagnosis and management of chronic inducible urticaria (CIndU) extend, revise and update our previous consensus report on physical urticarias and cholinergic urticaria (Allergy, 2009). The aim of these recommendations is to improve the diagnosis and management of patients with CIndU. Our recommendations acknowledge the latest changes in our understanding of CIndU, and the available therapeutic options, as well as the development of novel diagnostic tools.
Simplification of Insulin Regimen in Older Adults and Risk of Hypoglycemia
Authors: Medha N. Munshi, Christine Slyne, Alissa R. Segal, Nora Saul, Courtney Lyons, Katie Weinger
Journal: JAMA Internal Medicine (2016)

This case series describes HbA1c levels and frequency of hypoglycemia among older patients with type 2 diabetes whose treatment regimen was simplified to once-a-day glargine with or without noninsulin agents.
The misdiagnosis of epilepsy
Authors: D. Chadwick
Journal: BMJ (2002)

The case of Dr Andrew Holton, consultant paediatrician at Leicester Royal Infirmary, highlights once again some of the dangers and pitfalls in the diagnosis and management of epilepsy. He has been suspended and referred to the General Medical Council after a review of 214 children seen by him showed that 171 gave definite or possible “cause for concern.” Just over a third of the children were not thought to have had epilepsy, and just under a third were thought to have been overtreated.1 Both are common pitfalls in the management of epilepsy.

The review also made clear that Dr Holton's training fell well short of what would be required for his post. Although a consultant in paediatrics, Dr Holton was not a paediatric neurologist, of whom there are just 62 in the United Kingdom. The report also points to professional isolation and under-resourcing as important mitigating factors in Dr Holton's practice. This episode graphically illustrates the potential consequences of the shortcomings identified in 2000 by the Clinical Standards Advisory Group …
You
Authors: Ali Mendelson
Journal: JAMA (2014)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Diagnoses and Prevalence of HIV Infection Among Hispanics or Latinos — United States, 2008–2013
Authors: Kristen Mahle Gray, Eduardo E Valverde, Tian Tang, Azfar-e-Alam Siddiqi, H. Irene Hall
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Hispanics or Latinos represent about 17% of the total U.S. population and are disproportionately affected by human immunodeficiency virus (HIV) infection in the United States. In 2013, the rate of HIV diagnosis among Hispanics or Latinos (18.7) was nearly three times that of non-Hispanic whites (6.6). To better characterize HIV infection among Hispanics or Latinos aged ≥13 years in the United States, CDC analyzed data from the National HIV Surveillance System (NHSS). During 2008-2013, the rate of diagnoses of HIV infection among adult and adolescent Hispanics or Latinos decreased from 28.3 per 100,000 population in 2008 to 24.3 in 2013 (estimated annual percentage change [EAPC] = -3.6); however, the number of diagnoses among males with infection attributed to male-to-male sexual contact increased 16%, from 6,141 in 2008 to 7,098 in 2013 (EAPC = 3.0). In 2013, the rate of diagnosis of HIV infection among males (41.3) was six times the rate among females (6.8). During 2008-2013, behavioral risk factors for HIV infection among Hispanics or Latino differed among males and females and by place of birth. Among Hispanic or Latino males born in Puerto Rico, the proportion of HIV infections attributed to injection drug use (24.9%) was greater than among those born elsewhere. Among HIV-infected Hispanic or Latino females, those born in the United States (21.2%) and Puerto Rico (20.5%) had a greater proportion of HIV infections attributed to injection drug use than those born elsewhere. Additional interventions and public health strategies to further decrease the rates of HIV among the Hispanic or Latino population are needed.
The dexamethasone suppression test in depressed, dysthymic, and nondepressed children
Authors: L K Petty, J R Asarnow, G A Carlson, L Lesser
Journal: American Journal of Psychiatry (1985)

Dexamethasone suppression tests were given to seven children with major depression, six dysthymic children, and 17 children without affective disorders. The test showed sensitivity for major depressive disorder (87%) but a low specificity (53%).
Benefits of Prophylactic Use of Personalized Insoles for Patients Treated with Regorafenib
Authors: Yasushi Tsuji, Hiromitsu Kitayama, Junko Sugiyama, Hisashi Sugimoto, Syuichi Takasaki, Kaoru Mitsuno, Masaaki Hirayama
Journal: Annals of Oncology (2014)
Eligibility and extrapolation in cancer clinical trials.
Authors: C B Begg, P F Engstrom
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.6.962 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3585451 Eligibility and extrapolation in cancer clinical trials. C B BeggxC B BeggSearch for articles by this author , P F EngstromxP F EngstromSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.6.962 First Page PDF © 1987 by American Society of Clinical Oncology
Auditory evoked potentials and selective attention in formerly hyperactive adolescent boys
Authors: A J Zambelli, J S Stamm, S Maitinsky, D L Loiselle
Journal: American Journal of Psychiatry (1977)

Although many of the prominent symptoms of minimal brain dysfunction (MBD) subside during pubescence, adolescents who had MBD during childhood may have persistent neuropsychological dysfunctions. The authors studied the auditory average cortical evoked potentials and behavioral responses of 9 formerly hyperactive adolescent boys and 9 matched control subjects who performed a selective attention task. Experimental subjects showed indications of impairment on both electrophysiological and behavioral measures of selective attention. Although the findings are consistent with a neurodevelopmental lag interpretation of MBD, they may also imply a persistent dysfunction related to the frontal association cortex.
Serial ECG measurements at controlled plasma levels of nortriptyline in depressed children
Authors: B Geller, Z Q Farooki, T B Cooper, E C Chestnut, A S Abel
Journal: American Journal of Psychiatry (1985)

The authors investigated ECG measurements in 21 children with major depressive disorder treated with nortriptyline at plasma levels of 50-100 ng/ml. P-R and QRS intervals and heart rate measured at baseline and once a week during treatment remained within guidelines.
Personal and social resources in children of patients with bipolar affective disorder and children of normal control subjects
Authors: D Pellegrini, S Kosisky, D Nackman, L Cytryn, D H McKnew, E Gershon, J Hamovit, K Cammuso
Journal: American Journal of Psychiatry (1986)

The authors examined the personal resources (social problem-solving ability, internal locus of control, self-esteem, and self-perceived competence) and social resources (social network structure and support) in 23 children of patients with bipolar affective disorder (probands) and 33 children of normal control parents. Positive resource profiles were related to psychiatric well-being in the offspring. Nondisordered probands, in particular, demonstrated a strikingly positive profile of personal resources as well as a wide range of peer, sibling, and other kin supporters. Disordered probands had a strikingly negative set of personal resources and a relatively greater reliance on nonkin adult supporters. The absence of a supportive best friend was associated with affective disorder across offspring groups.