tbuckley/cabot-search huggingface dataset:
Induction docetaxel platinum 5-FU (TPF) followed by cetuximab-radiotherapy (cetux-RT) versus concurrent chemo-radiotherapy (CT/RT) in patients with N2b/c-N3 non operated stage III-IV squamous cell cancer of the head and neck (SCCHN): Results of the GORTEC 2007-02 phase III randomized trial.
Authors: Lionnel Geoffrois, Laurent Martin, Pascal Garaud, Dominique De Raucourt, Joelle Miny, Philippe Maingon, Cedrik Lafond, Claude Tuchais, Christian Sire, Emmanuel Babin, Alexandre Coutte, Yungan Tao, Frederic Rolland, Marie Helene Girard-Calais, Jean Bourhis
Journal: Journal of Clinical Oncology (2016)

6000 Background: Both CT/RT, and cetux-RT have been established as standard treatments in non-operated locally advanced SCCHN. Taxotere-Platinum-5FU (TPF) is a reference induction regimen in this type of cancer and it is not known whether the addition of induction TPF followed by cetux-RT could improve the outcome of patients with locally advanced SCCHN, as compared to standard CT/RT. Methods: GORTEC 2007-02 trial was restricted to patients (pts) with palpable cervical nodes (N2b/c-N3) and was run in parallel with GORTEC 2007-01 randomized trial testing the addition of concurrent chemotherapy (CT) to cetux-RT in pts with N0-N2a disease. Selection criteria were pts fit for receiving CT with non-metastatic, non-operated stage III-IV SCC of oral cavity, oro/hypopharynx and larynx, regardless of HPV status. Pts were randomized to receive concurrent CT/RT (arm A) or induction TPF plus cetux-RT (arm B). RT was 70 Gy (2 Gy per day, 5 days per week). Concurrent CT was: 3 cycles of carboplatin 70mg/m²/d + 5FU 600mg/m²/d D1-4 (Calais JNCI 1999). Primary end point was progression free survival (PFS). To detect a hazard ratio of 0.66, inclusion of 370 pts was required to achieve 80% power at 2-sided significance level of 0.05. Results: Between 2009 and 2013, 370 pts were randomized. The median follow-up was 31.2 months. There is no difference in PFS, median 11.5 m (arm A) vs 12.5 m (arm B); HR = 0.95, [95%CI 0.72-1.27; p = 0.74]. At the analysis time, 103 deaths were observed in arm A and 107 in arm B. There is no difference in median OS, 24.6 m vs 22.8 m; HR = 1.10; [95%CI 0.84-1.45; p = 0.48]. At 24 months, loco-regional control was 46.6% vs 43.3; HR = 0.97; [95%CI 0.73-1.30; p = 0.85] and distant free metastasis 86.4% vs 92.9% HR = 0.50; [95%CI 0.22-1.11; p = 0.081]. Grade 3-4 neutropenia occurred in 25.8% of pts in arm B vs none in arm A. Conclusions: GORTEC 2007-02 failed to demonstrate any superiority of induction TPF followed by cetux-RT vs CT/RT in this category of very poor prognosis locally advanced SCCHN. CT/RT remains the standard of care in this population. Clinical trial information: NCT01233843.
Memory B Cells Display Changes In The Expression Pattern Of Genes Related To Cell Survival In Elderly Individuals
Authors: Alicia Baez, Isabel Alvarez-Laderas, Jose Ignacio Piruat, Teresa Caballero-Velazquez, Africa Millan-Ucles, María Victoria Barbado, Mayte Medrano, Estefania Garcia-Guerrero, Luis Ignacio Sanchez-Abarca, Jose Antonio Perez-Simón, Ildefonso Espigado
Journal: Blood (2013)
Case 24-1967
Authors: Bernard Kliman, Robert E. Scully
Journal: New England Journal of Medicine (1967)

Presentation of Case First admission. A seventy-year-old man entered the hospital because of diarrhea, fatigue and dyspnea.Seven years previously an arteriosclerotic aneurysm of the abdominal aorta had been resected and replaced by a Dacron prosthesis. X-ray films of the chest were normal. Fourteen months later midabdominal pain and diarrhea developed abruptly, and a tender mass was palpable in the right lower quadrant of the abdomen. Surgical exploration revealed an abscess cavity behind the terminal ileum; the base of the appendix was ligated, the stump was enfolded, and the abscess cavity was drained. He was well thereafter until five . . .
Effects of thioridazine and withdrawal dyskinesias on workshop performance of mentally retarded young adults [retracted in Am J Psychiatry 1989 May;146(5):634]
Authors: S E Breuning, V J Davis, J L Matson, D G Ferguson
Journal: American Journal of Psychiatry (1982)

The authors conducted a two-part study of the effects of thioridazine and withdrawal dyskinesias on the workshop performance of mentally retarded young adults. In part 1, 80 mentally retarded subjects were divided into five groups of 16 according to administration, discontinuation, or nonadministration of thioridazine. The major finding was that thioridazine can impair the workshop performance of mentally retarded individuals. In part 2, 28 subjects were divided into four matched groups of 7 subjects each whose thioridazine dose was abruptly or gradually discontinued and who did or did not have withdrawal dyskinesias. Workshop performance declined with the onset of the dyskinesias and improved as the dyskinesias subsided.
Combination of the mTOR Inhibitor Rapamycin with the HSP90 Inhibitor 17-AAG Has Synergistic Activity in EBV Positive Post Transplant Lymphoproliferative Disorders (PTLD).
Authors: Yazan Alsayed, Ujjal Singha, Lanie Francis, Alissa Huston, Ganwei Lu, Judy Anderson, Suzanne Lentzsch, G. David Roodman, Irene M. Ghobrial
Journal: Blood (2005)
Brexit could worsen NHS staff shortages, doctors warn
Authors: Gareth Iacobucci
Journal: BMJ (2016)

UK healthcare leaders have publicly hailed the contribution of staff from other European Union countries, amid fears that the service may struggle to retain and recruit staff from the EU after the UK voted to leave the union.



Chris Hopson, chief executive of NHS Providers, said that there were indications that EU nationals were being deterred from working in the UK.



England’s health secretary, Jeremy Hunt, said that staff from other EU countries were “a crucial part of our NHS,” while NHS trusts and senior leaders paid tribute by taking part in a social media campaign with the hashtag #LoveOurEUStaff.

The display of solidarity came as concern was raised that widespread uncertainty in the wake of the referendum result was causing some nurses and doctors recruited from other EU countries to reconsider their decision to work in the UK. It also followed reports of some NHS staff being subjected to racist abuse after the referendum result on 24 June.

Scientists and researchers have also reacted with dismay at the news that the UK had voted to leave the EU.1 2 …
A randomized phase III study of cisplatin (CDDP), etoposide (ETOP) and irinotecan versus topotecan as second-line chemotherapy in patients with sensitive relapsed small-cell lung cancer (SCLC): Japan Clinical Oncology Group study JCOG0605
Authors: Koichi Goto, Yuichiro Ohe, Takashi Seto, Toshiaki Takahashi, Kazuhiko Nakagawa, Noboru Yamamoto, Akira Yokoyama, Koji Takeda, Makoto Nishio, Kiyoshi Mori, Miyako Satouchi, Toyoaki Hida, Shinzoh Kudoh, Naoyuki Nogami, Fumio Imamura, Katsuyuki Kiura, Hiroaki Okamoto, Toshiyuki Sawa, Taro Shibata, Tomohide Tamura
Journal: Journal of Clinical Oncology (2014)

7504 Background: ETOP and irinotecan are drugs known to exert promising activity in SCLC. A phase II study of weekly chemotherapy using a combination of CDDP, ETOP and irinotecan (PEI), which are known to inhibit both topoisomerase I and II, showed quite favorable outcome in patients with sensitive relapsed SCLC. A phase III study confirming the superiority of PEI over topotecan as second-line chemotherapy in patients with sensitive relapsed SCLC was conducted. Methods: SCLC patients who responded to first-line treatment and relapsed/progressed more than 90 days after the completion of first-line treatment were eligible for this study. Additional eligibility criteria included age 20-75 years, PS of 0-2, and adequate organ functions. Patients were randomized 1:1 to PEI, which consisted of CDDP (25 mg/m2) weekly for 10 weeks, ETOP (60 mg/m2) for 3 days on weeks 1, 3, 5, 7, and 9, and irinotecan (90 mg/m2) on weeks 2, 4, 6, 8 and 10 with granulocyte colony-stimulating factor support, or to topotecan (1.0 mg/m2) on days 1-5, every 3 weeks for 4 courses. The primary endpoint was overall survival. The planned sample size was 180 patients, to attain 80% power with a one-sided alpha of 5%. Results: From Sep. 2007 to Nov. 2012, 180 patients were randomized to topotecan (n=90) and PEI (n=90): median age 64 (44-75) years; M/F 155/25; LD/ED 45/135; PS 0-1/2 175/5. The overall survival was significantly longer in the PEI arm than in the topotecan arm (HR 0.67; 90% CI 0.51-0.88; p=0.0079) with MST 18.2 months vs. 12.5 months. PFS was also significantly longer in the PEI arm (HR 0.50; 95% CI 0.37-0.68; p<0.0001) with the median PFS 5.7 months vs. 3.6 months. Grade 3/4 adverse events in PEI and topotecan arms, respectively, were: neutropenia 83.3% vs. 85.6%; anemia 84.4% vs. 27.8%; thrombocytopenia 41.1% vs. 27.8%; diarrhea 7.8% vs. 0%; febrile neutropenia 31.1% vs. 6.7%. There was 1 treatment-related death in the PEI arm, and 2 in the topotecan arm. Conclusions: The combination chemotherapy with CDDP, ETOP and irinotecan should be considered as the standard second-line chemotherapy for sensitive relapsed SCLC. Clinical trial information: 000000828.
Atorvastatin and fluvastatin are associated with dose‐dependent reductions in cirrhosis and hepatocellular carcinoma, among patients with hepatitis C virus: Results from ERCHIVES
Authors: Tracey G. Simon, Hector Bonilla, Peng Yan, Raymond T. Chung, Adeel A. Butt
Journal: Hepatology (2016)

Statins are associated with delayed fibrosis progression and a reduced risk of hepatocellular carcinoma (HCC) in chronic hepatitis C virus (HCV). Limited data exist regarding the most effective type and dose of statin in this population. We sought to determine the impact of statin type and dose upon fibrosis progression and HCC in patients with HCV. Using the Electronically Retrieved Cohort of HCV Infected Veterans (ERCHIVES) database, we identified all subjects initiated on HCV antibody (anti-HCV) therapy from 2001 to 2014, and all incident cases of cirrhosis and HCC. Statin use was measured using cumulative defined daily dose (cDDD). Multivariable Cox's proportional hazard regression models were used to examine the relationship between statin use and development of cirrhosis and HCC. Among 9,135 eligible subjects, 1,649 developed cirrhosis and 239 developed incident HCC. Statin use was associated with a 44% reduction in development of cirrhosis (adjusted hazard ratio [HR]: 0.6; 95% confidence interval [CI]: 0.53, 0.68). The adjusted HRs (95% CI) of fibrosis progression with statin cDDD 28-89, 89-180, and >180 were 0.74 (0.59, 0.93), 0.71 (0.59, 0.88), and 0.6 (0.53, 0.68), respectively. Mean change in FIB-4 score with atorvastatin (n = 944) and fluvastatin (n = 34) was -0.17 and -0.13, respectively (P = 0.04), after adjustment for baseline FIB-4 score and established predictors of cirrhosis. Statin use was also associated with a 49% reduction in incident HCC (adjusted HR: 0.51; 95% CI: 0.36, 0.72). A similar dose-response relationship was observed.In patients with chronic HCV, statin use was associated with a dose-dependent reduction in incident cirrhosis and HCC. Atorvastatin and fluvastatin were associated with the most significant antifibrotic effects, compared with other statins. (Hepatology 2016;64:47-57).
Guideline for Hand Hygiene in Health-Care Settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC/SHEA/APIC/IDSA Hand Hygiene Task Force
Authors: John M. Boyce, Didier Pittet
Journal: MMWR Morbidity and Mortality Weekly Report (2002)

The Guideline for Hand Hygiene in Health-Care Settings provides health-care workers (HCWs) with a review of data regarding handwashing and hand antisepsis in health-care settings. In addition, it provides specific recommendations to promote improved hand-hygiene practices and reduce transmission ofpathogenic microorganisms to patients and personnel in health-care settings. This report reviews studies published since the 1985 CDC guideline (Garner JS, Favero MS. CDC guideline for handwashing and hospital environmental control, 1985. Infect Control 1986;7:231-43) and the 1995 APIC guideline (Larson EL, APIC Guidelines Committee. APIC guideline for handwashing and hand antisepsis in health care settings. Am J Infect Control 1995;23:251-69) were issued and provides an in-depth review of hand-hygiene practices of HCWs, levels of adherence of personnel to recommended handwashing practices, and factors adversely affecting adherence. New studies of the in vivo efficacy of alcohol-based hand rubs and the low incidence of dermatitis associated with their use are reviewed. Recent studies demonstrating the value of multidisciplinary hand-hygiene promotion programs and the potential role of alcohol-based hand rubs in improving hand-hygiene practices are summarized. Recommendations concerning related issues (e.g., the use of surgical hand antiseptics, hand lotions or creams, and wearing of artificial fingernails) are also included.
Chilcot: physical and mental legacy of Iraq war on UK service personnel
Authors: Neil Greenberg, Anthony Bull, Simon Wessely
Journal: BMJ (2016)

Long term consequences remain unknown, particularly for “unexpected survivors”

The much awaited Chilcot report focused on the legitimacy of the UK going to war in Iraq.1 But the UK citizens most directly affected by the war were members of the armed forces and their families. A total of 179 British service personnel were killed in the conflict, and many more received life changing physical and mental injuries. The Ministry Of Defence reports a total of 5970 casualties, including deaths up to July 2009.2

In April 2003 the UK Ministry of Defence commissioned an independent study of the health and wellbeing of Iraq war veterans (Chilcot, 16.2, 58-). This study, now completing its third wave of data collection, compared military personnel who had or had not been to Iraq, and found no new “Iraq war syndrome”3; no significant increase in probable post-traumatic stress disorder (PTSD) or common mental health disorders; and only a modest increase in …
Gender weighting of DSM-III-R personality disorder criteria
Authors: J Sprock, R K Blashfield, B Smith
Journal: American Journal of Psychiatry (1990)

This study explored the gender weighting of the diagnostic criteria for personality disorders. Gender weighting was defined in terms of how 33 female and 17 male nonclinicians ranked the diagnostic criteria along a male-female dimension. Although the a priori expectation was that antisocial would be the prototypically masculine personality disorder and histrionic the feminine, the subjects ranked criteria from the sadistic category as the most masculine and those from the dependent category as the most feminine. These results and the subjects' gender weighting of criteria for borderline, obsessive-compulsive, and self-defeating personality disorders are analyzed in detail.
Too Sad
Authors: J J Frey
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Evaluation Of hOCT1expression In Patients With Chronic Myeloid Leukemia (CML) Treated With Imatinib In First Line
Authors: Cintia Do Couto Mascarenhas, Maria Helena Almeida, Eliana C M Miranda, Bruna Virgilio, Marcia Torresan Delamain, Gislaine O. Duarte, Vagner O Duarte, Carmino A De Souza, Katia B. Pagnano
Journal: Blood (2013)
Studies on the Anemia of Tumor-Bearing Animals. IV. Distribution of Radioiron After the Extravascular Injection of Labeled Erythrocytes&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Robert E. Greenfield, William R. Sterling, Vincent E. Price
Journal: JNCI Journal of the National Cancer Institute (1960)

Previous studies (1–3) have shown that certain rat tumors contain large amounts of iron which arise primarily from hemoglobin iron in hemorrhagic areas of the tumor. The present studies attempt to determine to what degree the host is able to reutilize this iron for red-cell synthesis. Because of the complexity of the problem in tumors, initial studies were made on the fate of iron from extravascularly injected cells in normal rats. When intact erythrocytes which had been labeled with Fe59 were injected into the gastrocnemius muscle of normal rats, the radioiron left the site of injection very slowly, at a rate of 1 percent per day. After 60 days only 18 percent had been reutilized for the synthesis of new red cells. The rate at which radioiron from labeled cells left the injection site in the leg was only slightly increased in tumor-bearing animals or in animals which had been made anemic by repeated hemorrhage. In contrast, when erythrocytes containing Fe59-labeled hemoglobin were lysed and injected into the gastrocnemius muscle of normal rats, 55 percent of the radioiron had left the injection site within 24 hours and 35 percent was recovered in the liver. In later experiments, a slow rate was noted when intact cells labeled with Fe59 were injected into the tumor tissue of tumor-bearing animals and into the subcutaneous tissue of normal animals. The slow reutilization of iron from injected blood, in these experiments, suggests that the iron from extravasated blood may also be only slowly reutilized in normal and tumor-bearing rats.
Hospitalization After a Return Visit to the Emergency Department
Authors: Piyush Kalakoti, Christina Notarianni, Anil Nanda
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AMA calls for end to ban on gun violence research
Authors: Owen Dyer
Journal: BMJ (2016)

The American Medical Association, whose annual meeting declared gun violence in the United States a public health emergency earlier this month, will lend its formidable lobbying arm to efforts to overturn a congressional ban on government sponsored epidemiological research into factors behind gun deaths.

“An epidemiological analysis of gun violence is vital so physicians and other health providers, law enforcement, and society at large may be able to prevent injury, death, and other harms to society resulting from firearms,” said the association’s president, Steven Stack, in a statement.

The US Centers for Disease Control and Prevention used to carry out research into gun violence but stopped in 1996, when the …
Urinalysis in the Evaluation of Hematuria
Authors: Jen-Jane Liu, J. Stephen Jones, Pravin K. Rao
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Avoiding the Unintended Consequences of Screening for Social Determinants of Health
Authors: Arvin Garg, Renée Boynton-Jarrett, Paul H. Dworkin
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Absence of standard in the management of Thymic Epithelial Tumors
Authors: G. Lo Russo, M. Macerelli, C. Proto, M. Vitali, D. Signorelli, R. Gallucci, M. Platania, F. Agustoni, N. Zilembo, M. Ganzinelli, A. Raimondi, A. Trama, F. de Braud, M.C. Garassino
Journal: Annals of Oncology (2015)