tbuckley/cabot-search huggingface dataset:
A network theory of mental disorders
Authors: Denny Borsboom
Journal: World Psychiatry (2017)

In recent years, the network approach to psychopathology has been advanced as an alternative way of conceptualizing mental disorders. In this approach, mental disorders arise from direct interactions between symptoms. Although the network approach has led to many novel methodologies and substantive applications, it has not yet been fully articulated as a scientific theory of mental disorders. The present paper aims to develop such a theory, by postulating a limited set of theoretical principles regarding the structure and dynamics of symptom networks. At the heart of the theory lies the notion that symptoms of psychopathology are causally connected through myriads of biological, psychological and societal mechanisms. If these causal relations are sufficiently strong, symptoms can generate a level of feedback that renders them self‐sustaining. In this case, the network can get stuck in a disorder state. The network theory holds that this is a general feature of mental disorders, which can therefore be understood as alternative stable states of strongly connected symptom networks. This idea naturally leads to a comprehensive model of psychopathology, encompassing a common explanatory model for mental disorders, as well as novel definitions of associated concepts such as mental health, resilience, vulnerability and liability. In addition, the network theory has direct implications for how to understand diagnosis and treatment, and suggests a clear agenda for future research in psychiatry and associated disciplines.
Screening for Improvement of Health Outcomes in Asymptomatic Obstructive Sleep Apnea
Authors: Gregory S. Carter
Journal: JAMA Neurology (2017)

Daniel E. Jonas, MD, MPH; Halle R. Amick, MSPH; Cynthia Feltner, MD, MPH; Rachel Palmieri Weber, PhD; Marina Arvanitis, MD, MPH; Alexander Stine, BA; Linda Lux, MPA; Russell P. Harris, MD, MPH
Granulocytic Precursors from Patients with ELA2-Mutant Severe Congenital Neutropenia Display a Transcriptional Profile Consistent with Activation of the Unfolded Protein Response.
Authors: Mark Murakami, Jun Xia, Catherine T. Jordan, Laurence A. Boxer, David Dale, Audrey A. Bolyard, Mary C. Dinauer, Daniel C. Link
Journal: Blood (2007)
Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics
Authors: Gunchul Shin, Adrian M. Gomez, Ream Al-Hasani, Yu Ra Jeong, Jeonghyun Kim, Zhaoqian Xie, Anthony Banks, Seung Min Lee, Sang Youn Han, Chul Jong Yoo, Jong-Lam Lee, Seung Hee Lee, Jonas Kurniawan, Jacob Tureb, Zhongzhu Guo, Jangyeol Yoon, Sung-Il Park, Sang Yun Bang, Yoonho Nam, Marie C. Walicki, Vijay K. Samineni, Aaron D. Mickle, Kunhyuk Lee, Seung Yun Heo, Jordan G. McCall, Taisong Pan, Liang Wang, Xue Feng, Tae-il Kim, Jong Kyu Kim, Yuhang Li, Yonggang Huang, Robert W. Gereau, Jeong Sook Ha, Michael R. Bruchas, John A. Rogers
Journal: Neuron (2017)
DDAVP at a Maximal Dose of 15 ug Administered Subcutaneously Is a Safe and Effective Alternative to 20 ug IV for Patients &gt; 50 kg with von Willebrand Disease or Mild Hemophilia A.
Authors: Joy Mangel, Lori Laudenbach, Sheila Schembri, Lawrence Jardine, Reinhard Lohmann
Journal: Blood (2005)
Non-Invasive Monitoring of Hepatic Iron Concentration during Oral Chelation in Patients with Non-Regularly Transfused β-Thalassemia/Hb E Disease.
Authors: Pensri Pootrakul, Wanida Chua-anusorn, Adam Fleming, Paul Clark, Pornpan Sirankapracha, Udom Kachintorn, Somsak Chanyawattiwongse, Pichest Metarugcheep, Tim St. Pierre
Journal: Blood (2004)
Modeling Chronic Myeloid Leukemia in Immunodeficient Mice Reveals an Inflammatory State with Expansion of Aberrant Mast Cells and Accumulation of Pre B Cells
Authors: Maria Askmyr, Helena Agerstam, Henrik Lilljebjörn, Nils Hansen, Christine Karlsson, Niklas Landberg, Carl Hogberg, Carin Lassen, Marianne Rissler, Johan Richter, Mats Ehinger, Marcus Jaras, Thoas Fioretos
Journal: Blood (2014)
HIV-1 Nef-induced FasL induction and bystander killing requires p38 MAPK activation. Commentary
Authors: Karuppiah Muthumani, Andrew Y. Choo, Daniel S. Hwang, Arumugam Premkumar, Nathanael S. Dayes, Crafford Harris, Douglas R. Green, Scott A. Wadsworth, John J. Siekierka, David B. Weiner, Jean-Luc Perfettini, Guido Kroemer
Journal: Blood (2005)
Molecular disease monitoring using circulating tumor DNA in myelodysplastic syndromes
Authors: Paul Yeh, Michael Dickinson, Sarah Ftouni, Tane Hunter, Devbarna Sinha, Stephen Q. Wong, Rishu Agarwal, Ravikiran Vedururu, Kenneth Doig, Chun Yew Fong, Piers Blombery, David Westerman, Mark A. Dawson, Sarah-Jane Dawson
Journal: Blood (2017)
CD56(+)CD146(+) Cells in Normal Human Bone Marrow-Stroma Proliferated to Form Tumors in severe Combined Immunodeficiency Mice
Authors: Ryosuke Shirasaki, Haruko Tashiro, Yoko Oka, Tadashi Yamamoto, Nobu Akiyama, Kazuo Kawasugi, Naoki Shirafuji
Journal: Blood (2011)
Whole genome sequencing reveals high-resolution epidemiological links between clinical and environmental Klebsiella pneumoniae
Authors: Chakkaphan Runcharoen, Danesh Moradigaravand, Beth Blane, Suporn Paksanont, Jeeranan Thammachote, Suthatip Anun, Julian Parkhill, Narisara Chantratita, Sharon J. Peacock
Journal: Genome Medicine (2017)

Klebsiella pneumoniae is a gram-negative bacterial species capable of occupying a broad range of environmental and clinical habitats. Known as an opportunistic pathogen, it has recently become a major causative agent of clinical infections worldwide. Despite growing knowledge about the highly diverse population of K. pneumoniae, the evolution and clinical significance of environmental K. pneumoniae, as well as the relationship between clinical and environmental K. pneumoniae, are poorly defined. We isolated and sequenced K. pneumoniae from in-patients in a single hospital in Thailand, as well as hospital sewage, and surrounding canals and farms within a 20-km radius. Phylogenetic analysis of 77 K. pneumoniae (48 clinical and 29 non-clinical isolates) demonstrated that the two groups were intermixed throughout the tree and in some cases resided in the same clade, suggesting recent divergence from a common ancestor. Phylogenetic comparison of the 77 Thai genomes with 286 K. pneumoniae from a global collection showed that Thai isolates were closely related to the clinical sub-population of the global collection, indicating that Thai clinical isolates belonged to globally circulating lineages. Dating of four Thai K. pneumoniae clades indicated that they emerged between 50 and 150 years ago. Despite their phylogenetic relatedness, virulence factors and β-lactamase resistance genes were more numerous in clinical than in environmental isolates. Our results indicate that clinical and environmental K. pneumoniae are closely related, but that hospitals may select for isolates with a more resistant and virulent genotype. These findings highlight the clinical relevance of environmental K. pneumoniae isolates.
In Reply
Authors: Sharon Marsh, Jim Paul, Howard L. McLeod, Robert Brown
Journal: Journal of Clinical Oncology (2008)

Branford et al correctly highlight that ethnic variability in allele frequencies can be a major source of variability between pharmacogenetic studies. Indeed, as we discuss in the original publication,1 population differences along with other differences between studies (eg, sample size, tumor type, and treatment regimen) are all possible causes for the lack of replication of previous findings.
Genetic Susceptibility to Therapy-Related Leukemia – Role of Expression Quantitative Trait Loci (eQTL)
Authors: Yan Ding, Can-Lan Sun, Liton Francisco, Liang Li, Min Li, Brian Hahn, Jennifer Noe, Garrett P Larson, Stephen J. Forman, Ravi Bhatia, Smita Bhatia
Journal: Blood (2011)
Rituximab Containing Autologous Stem Cell Transplantation May Be Curative in Mantle Cell Lymphoma for Patients in First Remission, but Not for Patients with Recurrent Disease.
Authors: Constantine S Tam, Roland Bassett, Celina Ledesma, Martin J. Korbling, Grace-Julia Okoroji, Robyn Harrell, Yvonne Hsu, Leandro De Padua Silva, Amin M. Alousi, Chitra M Hosing, Partow Kebriael, Gabriela Rondon, Sergio Giralt, Marcos De Lima, Paolo Anderlini, Uday Popat, Muzaffar H. Qazilbash, Barry Samuels, Richard E Champlin, Issa F Khouri
Journal: Blood (2008)
Survival Outcomes of Double and Triple-Only Combination Anti-Myeloma Chemotherapeutic Regimens on 26 Multiple Myeloma Patients Seen in a Sub-Saharan African Country
Authors: Ogbonna Collins Nwabuko, Martin Anazodo Nnoli, Elizabeth Eneikido Igbigbi, Dorathy Adaunwa Okoh, Ijezie Innocent Chukwuonye
Journal: Blood (2014)
General practices won’t be forced to open seven days a week, says NHS chief
Authors: Gareth Iacobucci
Journal: BMJ (2017)

General practices in England will not be forced to open seven days a week despite recent threats from Number 10 that they might lose funding if they didn’t extend their hours, NHS England’s chief executive, Simon Stevens, has told The BMJ. 

Recent reports in the national press said that the prime minister, Theresa May, was prepared to withhold funding allotted for extended opening hours unless general practices could prove that they were telling their patients about additional appointment slots and offering appointments at convenient times.1

The intervention prompted an angry backlash from GPs,2 who accused the government of …
Apoptotic and Multi-Drug Resistance Profile in Elderly AML Patients.
Authors: Maria-Belen Vidriales, Lilia Suarez, José García-Laraña, Antonio López, María José Moreno, Rafael Martinez, Mar Tormo, Esperanza Lavilla, Consuelo López-Berges, María de Santiago, Jesús F. San Miguel, Alberto Orfao
Journal: Blood (2004)
Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity
Authors: Andrew G. Levine, Saskia Hemmers, Antonio P. Baptista, Michail Schizas, Mehlika B. Faire, Bruno Moltedo, Catherine Konopacki, Marc Schmidt-Supprian, Ronald N. Germain, Piper M. Treuting, Alexander Y. Rudensky
Journal: The Journal of Experimental Medicine (2017)

The regulatory T cell (T reg cell) T cell receptor (TCR) repertoire is highly diverse and skewed toward recognition of self-antigens. TCR expression by T reg cells is continuously required for maintenance of immune tolerance and for a major part of their characteristic gene expression signature; however, it remains unknown to what degree diverse TCR-mediated interactions with cognate self-antigens are required for these processes. In this study, by experimentally switching the T reg cell TCR repertoire to a single T reg cell TCR, we demonstrate that T reg cell function and gene expression can be partially uncoupled from TCR diversity. An induced switch of the T reg cell TCR repertoire to a random repertoire also preserved, albeit to a limited degree, the ability to suppress lymphadenopathy and T helper cell type 2 activation. At the same time, these perturbations of the T reg cell TCR repertoire led to marked immune cell activation, tissue inflammation, and an ultimately severe autoimmunity, indicating the importance of diversity and specificity for optimal T reg cell function.
The role of stereotactic radiosurgery in the treatment of renal cell carcinoma patients with five or more brain metastases.
Authors: Alireza Mohammad Mohammadi, Samuel T. Chao, Brian I. Rini, Jorge A. Garcia, John H. Suh, Lilyana Angelov
Journal: Journal of Clinical Oncology (2012)

410 Background: Whole brain radiation therapy (WBRT) is considered standard treatment in patients with multiple brain metastases (BM). However, WBRT has limited efficacy in patients with BM from radio resistant tumors like renal cell carcinoma (RCC) where median survival is 2–4 months. The aim of this study is to evaluate outcomes in RCC patients with ≥5 BM treated with Stereotactic Radio-surgery (SRS) monotherapy or as part of a multimodality regimen. Methods: Data from 16 consecutive RCC patients with ≥5 simultaneous BM (99 lesions) treated with SRS at our institution (1999–2010) were analyzed. Patient demographics, tumor characteristics, treatment related factors and outcomes were statistically evaluated. Results: 12 male and 4 female patients (median age of 59) were treated. 62% of patients had concurrent systemic metastases to multiple organs at the time of treatment. 31% of patients were on active systemic treatment before SRS. Patients had prior cranial surgery 2(12%), WBRT 6(37%) and SRS 2(12%) previous to their presentation with ≥5 BM. Median interval between primary diagnoses and SRS was 2years (range 0–16). At the time of current SRS treatment 75% of patients had only mild neurological symptoms and median KPS was 80; 87% of patients were Recursive Partitioning Analysis Class II. Median number of lesion was 5 (max 10), and median total intracranial disease burden was 2cc (range 0.2–36.4). Post SRS for ≥5 BM, 9 of 16 patients required further intracranial therapy for new lesions, WBRT 3(19%) and SRS 6(37%). Mean follow up was 6.5 months from SRS for ≥5 BM (range 1-19). 12 patients (75%) died during follow up with neurological cause of death in 3(25%). Median overall survival (OS) was 7.1 months (range1–21). OS was 50% after 6 month and 31% after 1 year. Local control rate was achieved in 91% of targets in all evaluated patients. Conclusions: SRS is traditionally used to treat patients with a limited number of BM. This is the first series to evaluate the role of SRS in the management ≥5 BM in RCC. We demonstrate that using SRS in these patients results in excellent local disease control (91%) and acceptable OS. Hence, SRS should be considered in the ongoing management of patients even with extensive intracranial disease.
European Sub-Registry of Chronic Myelogenous Leukemia (CML) Patients (pts) in Failure after Imatinib Therapy (IFP): Rationale, Study Design and Current Enrollment.
Authors: Joelle Guilhot, Florence Tartarin, Markus Pfirmann, Arnon Nagler, Franck Nicolini, Philippe Rousselot, Kimmo Porkka, Gert Ossenkoppele, Jesper Stentoft, Francisco Cervantes, Gianantonio Rosti, Josef Thaler, Philipp le Coutre, Joerg Hasford, Rudiger Hehlmann, Francois Guilhot, European LeukemiaNet
Journal: Blood (2006)
Retrospective Study of the Efficacy of Bortezomib in Primary Systemic Amyloidosis.
Authors: Francis Buadi, Martha Q. Lacy, Angela Dispenzieri, Shaji Kumar, Suzanne Hayman, Kristen E Detweiler Short, David Dingli, Steven R. Zeldenrust, Philip R. Greipp, John A. Lust, Stephen J. Russell, Robert Kyle, Vincent Rajkumar, Morie A Gertz
Journal: Blood (2009)
The Kinetics of Etoposide (VP-16) Peripheral Blood Progenitor Cell (PBPC) Mobilization.
Authors: Brian J. Bolwell, Elizabeth Kuczkowski, Lisa Rybicki, Brad Pohlman, Steven Andresen, Ronald Sobecks, Janet Baker, Kelly Cherni, Laura Bernhard, Alison Vellani, Nicole Berry, Shawnda Sungren, Leslie Foster, Matt Kalaycio
Journal: Blood (2004)
High Cereblon Protein Expression Correlates with Improved Response and Survival in Myeloma Patients Treated with Lenalidomide
Authors: Alexander Klimowicz, Paola Neri, Andrew Belch, Michelle Dean, Li Ren, Kathy Gratton, Jiri Slaby, Jordan Johnson, Peter Duggan, Douglas A. Stewart, Nizar J. Bahlis
Journal: Blood (2012)
Treatment-limiting renal tubulopathy in patients treated with tenofovir disoproxil fumarate
Authors: L. Hamzah, S. Jose, J.W. Booth, A. Hegazi, M. Rayment, A. Bailey, D.I. Williams, B.M. Hendry, P. Hay, R. Jones, J.B. Levy, D.R. Chadwick, M. Johnson, C.A. Sabin, F.A. Post
Journal: Journal of Infection (2017)
The Importance of the Baby-Friendly Hospital Initiative
Authors: Lorraine Boyd, Marta Kowalska, George L. Askew
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Frequency of Thyroid Carcinoma in Brazilian <i>TP53 </i>p.R337H Carriers With Li Fraumeni Syndrome
Authors: Maria Nirvana da Cruz Formiga, Kelvin César de Andrade, Luiz Paulo Kowalski, Maria Isabel Achatz
Journal: JAMA Oncology (2017)

Li Fraumeni syndrome (LFS) is associated with a wide variety of tumors; nevertheless, thyroid carcinoma has not been evaluated in this syndrome. Due to the Brazilian founder mutation p.R337H, some tumors that have not been described in the classic LFS have been observed in a higher-than-expected prevalence in Brazil.To determine the frequency of thyroid carcinoma in Brazilian carriers of a founder TP53 p.R337H mutation.We reviewed medical records of patients with LFS with germline TP53 p.R337H mutation. For a better understanding of the correlation between thyroid carcinoma and LFS, tumor profile data of Brazilian carriers were analyzed. We included data from 193 patients with LFS with the TP53 p.R337H mutation from the database of the Department of Oncogenetics from the A.C. Camargo Cancer Center.Thyroid tumors found in this population were reviewed with regard to age at diagnosis, sex, histologic subtype, and other tumors presented by these patients.Overall, 101 of 193 TP53 p.R337H mutation carriers with LFS from 58 families were cancer affected and, among them, thyroid carcinoma presented a prevalence of 10.9% (3 men and 8 women). The mean age at diagnosis was 44 years (median [SD], 43 [14.77] years). All the cases were histologically classified as papillary carcinomas, with 2 of them exhibiting follicular variant. The most common other cancers in the patients with thyroid carcinoma were breast cancer (5 patients) and soft-tissue sarcoma (2 patients).Thyroid carcinoma may be associated with the Brazilian founder TP53 p.R337H mutation. Knowledge about this genotype/phenotype correlation is relevant to adjusting the LFS screening recommendations to these specific carriers.
Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus
Authors: Sookkasem Khositseth, Komgrid Charngkaew, Chatikorn Boonkrai, Poorichaya Somparn, Panapat Uawithya, Nusara Chomanee, D. Michael Payne, Robert A. Fenton, Trairak Pisitkun
Journal: Kidney International (2017)
Liver resection for multifocal hepatocellular carcinoma.
Authors: Peter Tae Wan Kim, Jihyun Jang, Sandra Fischer, Paul David Greig, Steven Gallinger, Alice Chia-chi Wei, Ian M McGilivray, Mark S Cattral, Sean P Cleary
Journal: Journal of Clinical Oncology (2012)

355 Background: Liver resection for multifocal hepatocellular carcinoma (HCC) is controversial. This study was conducted to outline our institution’s experience with liver resection for multifocal HCC. Methods: A retrospective review of patients who underwent liver resections from 1992 to 2011 for histologically confirmed hepatocellular carcinoma was performed. Multifocal disease was defined as more than 1 histologically proven HCC found in the liver resection specimens. Results: Of the 386 liver resections performed for HCC, 47 were performed for multifocal disease. Mean age was 60+11 years, and most patients (92%) had chronic liver disease. Hepatitis B was the most common etiology (60%), followed by hepatitis C (26%), and other etiologies (15%). Most patients were Child’s class A (89%). Most patients had intermediate Barcelona Clinic Liver Cancer (BCLC) stage (stage B) tumors (81%) and a minority of patients had early stage tumors (BCLC stage A, 19%). Major hepatectomy (&gt;2 segments) was performed in 87% with an in hospital mortality of 6.4%. Major complications (Clavien-Dindo scale &gt;3) occurred in 4 patients (9%). Median length of stay was 7 days and the rate of liver failure was 4.3%. Mean tumor number was 3+2 and the size of the largest lesion was 5+3 cm. Cirrhosis was present in 51% of patients. Majority of tumors were moderately differentiated (60%) and vascular invasion was present in 42%. The recurrence rate was 57% and the liver was the most common site of recurrence (81%). Treatment of recurrences occurred in 74% of patients: ablation (33%), chemotherapy (11%), transarterial chemoembolization (11%), resection (7.4%), sorafenib/radiation (7.4%) and transplantation (3.7%). Median disease free interval was 8 months and the overall survival was 18 months Conclusions: Liver resection for multifocal HCC can be performed safely in patients with chronic liver disease. Long term survival can be achieved in these patients and it should be considered as an option.
Induction of Sustained Early G1 Arrest by Selective Inhibition of CDK4 and CDK6 Primes Myeloma Cells for Synergistic Killing by Proteasome Inhibitors Carfilzomib and PR-047
Authors: Xiangao Huang, Kathryn Bailey, Maurizio Di Liberto, Francesco Parlati, Ruben Niesvizky, Susan Demo, Selina Chen-Kiang
Journal: Blood (2008)
The Prognostic Impact of High EVI1 expression In AML Is Due to Its Close Correlation to Rearrangements Involving EVI1 or MLL, which Are Cytogenetically Cryptic In a Subset of Patients: a Study on 332 Cases.
Authors: Claudia Haferlach, Vera Grossmann, Melanie Zenger, Tamara Alpermann, Alexander Kohlmann, Wolfgang Kern, Torsten Haferlach, Susanne Schnittger
Journal: Blood (2010)
Relapse Free Survival of Elderly AML Patients Is Comparable to That of Younger Adults When Treated with a Modified Dose Intensive Cytarabine Regimen.
Authors: Amelia A. Langston, Leonard T. Heffner, Donald Hutcherson, Jessica Neely, Christopher Flowers, Edmund K. Waller, Sagar Lonial, Hanna J. Khoury, Elliot Winton
Journal: Blood (2005)
Genome-Wide Analysis of B Cell Non-Hodgkin’s Lymphoma Disclosed Frequent Involvement of Genes in NFkB Pathway
Authors: Motohiro Kato, Kumi Nakazaki, Yasuharu Sato, Kengo Takeuchi, Masashi Sanada, Yoshitaka Asakura, Satsuki Muto, Yuyan Chen, Junko Takita, Yasuhide Hayashi, Takashi Igarashi, Toshiki Watanabe, Kensei Tobinai, Yuichi Ishikawa, Shigeo Mori, Mineo Kurokawa, Tadashi Yoshino, Yukio Kobayashi, Seishi Ogawa
Journal: Blood (2008)