tbuckley/cabot-search huggingface dataset:
OC-066 Influence Of Extraversion On Brain Activity At Baseline, Pain Anticipation And Visceral Pain Processing
Authors: JK Ruffle, SJ Coen, AD Farmer, M Kano, V Giampietro, S Williams, Q Aziz
Journal: Gut (2014)

<h3>Introduction</h3> Eysenck proposed ‘trait theory’ of personality, where the dimensions extraversion (degree of optimism and sociability) and neuroticism (degree of anxiety and fear) encompass numerous individual qualities. Whilst the influence of neuroticism on the brain processing of pain is well studied, the role of extraversion in pain processing remains to be investigated and thus this was the aim of our study using functional magnetic resonance imaging (fMRI). <h3>Methods</h3> 33 healthy volunteers participated in the study, all of whom consented in writing (17 male; mean age 29, range 20–53, all right handed). Extraversion was measured using the Eysenck Personality Questionnaire. fMRI data was acquired using a 3T GE MRI scanner during rest, anticipation of pain, and painful distal oesophageal balloon distention. During fMRI, 480 T2* weighted images per slice (40 × 3 mm slices, 0.3 interslice gap, TE 30 ms, TR 2500 ms, flip angle 80°, matrix size 642, sum of images per scan = 19,200) were captured to illustrate blood oxygen level dependent (BOLD) contrast during the different experimental events. The effects of extraversion on fMRI response during these events were subsequently determined using ANOVA brain activation mapping analyses within XBAM, a statistical package of image processing and statistical inference. <h3>Results</h3> There was a diversity of extraversion scores (range 6–22), which did not influence pain threshold or rating. High extraversion was associated with significantly greater activity in the left cuneus (Brodmann Area (BA) 18) during rest (p &lt; 0.001) and the right insula (BA13) during both anticipation (p &lt; 0.0002) and pain (p &lt; 0.0008). Low extraversion was associated with significantly greater brain activity in numerous regions during pain anticipation, including the bilateral precuneus (BA31), bilateral lingual gyrus (BA18) and the right inferior temporal gyrus (p &lt; 0.0001). <h3>Conclusion</h3> Our results suggest that the brain processing of pain is influenced by the personality dimension of extraversion and therefore like other personality dimensions such as neuroticism, extraversion should be controlled for in brain imaging studies of pain in health and disease. <h3>Disclosure of Interest</h3> None Declared.
PMO-181 Long term follow-up of chronic hepatitis B (HBV) patients treated with pegylated interferon: single centre experience
Authors: W Smethurst, L Fenton, K Forrester, R Simpson, S Moreea
Journal: Gut (2012)

<h3>Introduction</h3> Pegylated Interferon (PEG IFN) is NICE approved for the treatment of chronic hepatitis B (HBV) but it is now known that the response is genotype dependent. To analyse the long term outcome of chronic hepatitis B patients treated with Pegylated Interferon. <h3>Methods</h3> Retrospective analysis of our hepatitis B database to identify HBV patients treated with PEG IFN. The following data were obtained from the patient9s records and our electronic reporting systems: demographics, length of treatment, ALT and viral load (HBV PCR) at various points during and after treatment. <h3>Results</h3> 13 patients (9 males, average age 36.8 yrs; 4 females, average age 34.7 yrs) were treated from April 2007 with a mean follow-up of 33 months (133 weeks). There were 8 eAg +ve and 5 eAg –ve patients. None were co-infected with the Delta virus. In the eAg +ve group, there were 3 genotype D (South Asians), 3 genotype C (2 Chinese and 1 South Asian), 1 genotype B (South Asian) and 1 unknown genotype (white Caucasian). All had a raised ALT and mild changes (Ishak fibrosis score 0–2) on liver biopsy. 4/8 (50%)—3 Genotype C, 1 Genotype D—achieved eAg seroconversion to eAb +ve and 1/8 (13%)—unknown genotype—achieved sAg clearance at the end of treatment. ALT normalised only in those who seroconverted. HBV PCR was &lt;200 IU/ml in 5/8 patients at week 24 and 4/8 patients had undetectable PCR at the end of treatment at week 48 (lack of data for two patients, one failed treatment and one HBV PCR 42 IU/ml). There were three cases of lamivudine resistance. Four patients relapsed within 1-year post PEG IFN (all genotype D) and required treatment with tenofovir (+/− lamivudine). In the eAg –ve group, there were four genotype D patients (all South Asians, two co-infected with HCV genotype 3a) and 1 unknown genotype (Chinese). The three non co-infected patients showed good response at the end of treatment but all relapsed within 1 year and all needed further treatment with nucleoside analogues with good viral response. The co-infected patients achieved sustained viral response for HCV and maintained a low HBV viral load. <h3>Conclusion</h3> This study confirms good outcomes for non-genotype D patients treated with PEG IFN. However, eAg –ve patients with genotype D treated with PEG IFN tend to relapse after treatment. The use of HBsAg quantification will help to tailor treatment in the future. <h3>Competing interests</h3> None declared.
EVALUATION OF CEREBRAL PERFUSION AND METABOLISM IN CHRONIC CLOSED HEAD INJURY (CHI) BY PET
Authors: P. W. Schneider, C Y.O. Wong, J. Juni, D. Fink-Bennett, S. Viola, R. Long, M. Gaskill, D. Kondas, R. Sharma, H. Balon, R. Ponto, H. Dworkin
Journal: Clinical Nuclear Medicine (1999)

Scientific Abstracts: Central Chapter, Society Of Nuclear Medicine, April 9-11, 1999, Cleveland Sheraton City Center Cleveland, Oh
Resection of rectal carcinoids with the newly introduced endoscopic full-thickness resection device
Authors: Martin Grauer, Andreas Gschwendtner, Claus Schäfer, Helmut Neumann
Journal: Endoscopy (2016)

Rectal carcinoids show an increasing incidence and are malignant tumors that can metastasize [1]. According to the recent guidelines of the European Neuroendocrine Tumor Society, rectal carcinoids of less than 2 cm in diameter could be resected endoscopically [2]. As highlighted in a recent systematic review and meta-analysis, the best endoscopic treatment option is endoscopic submucosal dissection (ESD) or so-called modified endoscopic mucosal resection techniques, including the band-ligation and cap-fitted techniques [3] [4].
PREDICTORS FOR RETROGRADE PROCEDURE FAILURE IN PERCUTANEOUS CORONARY INTERVENTION FOR CHRONIC TOTAL OCCLUSIONS: REPORT FROM JAPANESE MULTICENTER REGISTRY WITH 5 YEARS DATA
Authors: Katsuyuki Hasegawa, Makoto Muto, Masahisa Yamane, Etsuo Tsuchikane, Toshiya Muramatsu, Atsunori Okamura, Yasumi Igarashi, Yoriyasu Suzuki, Tsutomu Fujita, Yuji Oikawa, Shigeru Nakamura
Journal: Journal of the American College of Cardiology (2015)
Total and Capillary Fingertip Blood Flow in Raynaud's Phenomenon
Authors: Jay D. Coffman, Alan S. Cohen
Journal: New England Journal of Medicine (1971)

Total (plethysmography) and capillary (radioisotope disappearance rate) fingertip flows were measured in 24 patients with Raynaud's phenomenon and compared to 10 normal subjects in a warm room and during reflex sympathetic nerve stimulation by body cooling. Arteriovenous shunt flow was estimated by subtraction of capillary from total flow. Patients with Raynaud's phenomenon had a significantly smaller capillary flow in both warm (6.4 vs. 10 ml per 100 g per minute) and cool (4.0 vs. 7.0 ml) rooms than normal subjects. With body cooling, total and arteriovenous shunt flow, but not capillary flow, decreased significantly in normal controls, whereas all three decreased in Raynaud's phenomenon. During oral reserpine treatment, 11 patients with Raynaud's phenomenon showed a significantly larger capillary flow during warming (8.7 vs. 5.7 ml) and cooling (6.2 vs. 2.8 ml). Patients with Raynaud's phenomenon have a smaller finger nutritional (capillary) flow than normal subjects, and this flow decreases significantly during sympathetic stimulation; reserpine produces increased finger nutritional flow in these patients.
Carcinoma Arising in Choledochocele: Is Choledochocele Innocent Bystander or Culprit?
Authors: T. H. Kim, J. S. Park, S. S. Lee, S. K. Lee, M.-H. Kim
Journal: Endoscopy (2002)

We read with interest the article by Ohtsuka et al. [1], entitled “Carcinoma arising in choledochocele.” The prevalence of 27 % for periampullary carcinoma in choledochoceles in their study was much higher than that of 2.5 % previously reported by Ladas et al. [2]. We have already published a study of a large series of choledochoceles (n = 17) treated by endoscopic sphincterotomy (ES) [3]. During long-term follow-up (mean 3 years) of all patients, however, we have never found periampullary cancer in those patients. Therefore, we would like to raise some questions.
Use of a Water Enema to Facilitate Localization of Gastrointestinal Hemorrhage During Tc-99m Labeled RBC Scintigraphy
Authors: JANE S. BENNETT, JACOB CYNAMON, LIONEL S. ZUCKIER
Journal: Clinical Nuclear Medicine (1996)

The authors report the use of a tap water enema to displace, and thereby localize, a site of colonic bleeding that had remained fixed in the left lower quadrant of the abdomen and could not be accurately localized. In similar cases, this maneuver may help to localize colonic bleeds in a timely fashion, avoiding protracted imaging and obviating the need for additional diagnostic testing.
Abstract 3460: Tumor budding is a predictive feature for lymph node metastasis in invasive ductal breast cancer.
Authors: Mafalda Trippel, Katrin Pfaltz, Bodour Salhia, André Grogg, Inti Zlobec, Coya F. Tapia
Journal: Cancer Research (2013)

Abstract Background: Tumor budding is a phenomenon associated with epithelial mesenchymal transition and correlates with tumor invasiveness and metastasis in colon cancer. In breast cancer this histomorphological feature has not yet been determined. In this study we investigated the prognostic value of peritumoral budding (PTB) and intratumoral budding (ITB) in invasive ductal breast cancer and its correlation with lymph node status. Method: Two pathologists counted tumor buds within the tumor (ITB) and at the periphery (PTB) of 90 primary invasive ductal breast cancers. ITB and PTB were scored on whole tissue sections stained with a PanCK antibody. Budding was defined as isolated single cancer cells or microscopic cell clusters composed of ≥1 or up to 5 cells. A tumor was designated to have high-grade budding if it had an average of &amp;gt;10 buds. PTB and ITB were then correlated with pathological features of breast cancer. Results: Forty-eight percent (n=43) and 50% (n=45) were considered high-grade for either ITB or PTB, respectively. High-grade PTB was significantly (p=0.0044) associated with lymph node metastasis and ITB was significantly (p=0.0018) associated with hormone receptor positive tumors. ITB and PTB were frequent in Her2 negative (50% and 53%) tumors and breast cancer with higher T-category &amp;gt;T3 (57%). Neither PTB nor ITB showed an association with tumor grade or proliferation index as measured by Mib-1 staining. Conclusion: For the first time, we report that PTB is a strong (p=0.0044) predictive tumor feature of lymph node metastasis in invasive ductal breast cancer. The association of PTB with metastatic disease may be due to an increased occurrence of lymph vessels found at the tumor periphery. Additional studies are ongoing to determine if tumor budding can select for more aggressive subtypes of invasive breast cancer. Citation Format: Mafalda Trippel, Katrin Pfaltz, Bodour Salhia, André Grogg, Inti Zlobec, Coya F. Tapia. Tumor budding is a predictive feature for lymph node metastasis in invasive ductal breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3460. doi:10.1158/1538-7445.AM2013-3460
NHS England slips further behind on its efficiency savings target
Authors: M. Limb
Journal: BMJ (2013)

NHS England has admitted that its projected efficiency savings are expected to fall 13% below the target this financial year.

NHS England had a target to achieve some £374m (€434m; $580m) in savings under the quality, innovation, productivity, and prevention (QIPP) programme in 2013-14, but an internal report says that it may fall £48.1m short of this—12.9% behind target, more than a third higher than the 9.2% shortfall forecast at the end of June 2013. Reduced savings in primary care (£22.5m behind target) account for the biggest element of the projected shortfall, the report says.

The figures, which cover the first quarter of the financial year 2013-14, appear in NHS England’s non-integrated single financial environment report, which has been released under a freedom …
Mitochondrial Toxicity Associated with Linezolid
Authors: Alex Soriano, Oscar Miró, Josep Mensa
Journal: New England Journal of Medicine (2005)

To the Editor: Linezolid belongs to a family of antimicrobial agents (oxazolidinones) that inhibit bacterial protein synthesis by preventing the fusion of 30S and 50S ribosomal subunits.1 Hyperlactatemia, metabolic acidosis, and peripheral neuropathy are adverse effects of linezolid,2,3 which could be related to the drug's capacity for interference with mitochondrial function.4 We studied mitochondria from three patients in whom asthenia and hyperlactatemia developed during a prolonged course of oral linezolid (600 mg every 12 hours). Patient 1, a 25-year-old man with Enterococcus faecium infection of a knee prosthesis, received oral linezolid. After three months, mild asthenia and hyperlactatemia developed . . .
AB0765 Quality of life and fatigue in patients with behcet’s disease
Authors: M. Can, F. Alibaz-Öner, B. Ilhan, S. Öner, N. Inanc, T. Ergun, G. Mumcu, H. Direskeneli
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Behcet's disease (BD) is a multi-systemic, chronic inflammatory disorder characterized by vasculitis. Fatigue, a common symptom of inflammatory rheumatological disorders such as systemic lupus erythematosus (SLE) and vasculitides, is insufficiently studied in BD. <h3>Objectives</h3> We aimed to assess fatigue in BD, comparing it with other patient-reported outcomes such as disability, quality of life (QoL) and anxiety/depression in this study. <h3>Methods</h3> Fifty-one patients followed as BD (F/M:32/19, mean age: 39.4 years) fullfilling the International Study Group Criteria (ISG,1990), 24 patients with SLE (F/M:23/1, mean age: 46.5 years) and 31 healthy controls (HC) (F/M: 24/7, mean age: 37.8 years) were enrolled to the study. The clinical activity score in BD was determined by Behcet's Syndrome Activity Scale (BSAS) and in SLE by SLEDAI. All subjects were asked to complete the Multi-dimensional assessment of fatigue (MAF) questionnaire. SF-36 and hospital anxiety and depression scales were also used to assess QoL together with health assessment questionnaire (HAQ). <h3>Results</h3> Mean fatigue score was similar among the three groups [22.6 (15.3), 26.6 (10.9) and 24.1 (11.8) in BD, SLE and HC respectively] (p=0.4). When BD patients were separately analysed in 2 groups (mucocutaneous (MC) (n=17) and major organ involvement (MO) (ocular, vascular and central nervous system) (n=21)), fatigue score was also not different among both groups [22.3(17.7) vs 21.2(17.0), MC and MO respectively]. However, BSAS score was observed to correlate with the fatigue score (r=0.5, p=0.001).HAQ scores were impaired in BD and SLE patients compared to HC [0.32(0.42), 0.42(0.36) and 0.07 (0.1), respectively] (p&lt;0.01). Anxiety [6.6 (4.2), 7.5 (4.1) and 6.0 (4.6) in BD, SLE and HC, respectively) (p&gt;0.05), and depression scores were similar [6.3 (4.1), 7.2 (3.1) and 5.8 (3.5) in BD, SLE and HC respectively] (p&gt;0.05) among the 3 groups. In subgroup analysis, SF-36 mental and physical components, depression and anxiety scores and HAQ were also not different between MC and MO groups. <h3>Conclusions</h3> Contrary to previous studies, in this hospital-based, observational cohort study, fatigue seems to be similar in magnitude in BD compared to SLE and HC. Although major organ involvement did not affect fatigue severity, an association of fatigue with disease activity is observed. <h3>Disclosure of Interest</h3> None Declared
Understanding reasoning: Let's describe what we really think about
Authors: Robert J. Sternberg
Journal: Behavioral and Brain Sciences (2011)

Abstract I suggest psychologists would more profitably study a totally different area of human reasoning than is discussed in the target article – the inductive reasoning people use in their everyday life that matters in consequential real-life decision making, rather than the deductive reasoning that psychologists have studied meticulously but that has relatively less ecological relevance to people's lives.
ATRIAL SEPTAL ANEURYSM AND CHIARI NETWORK ARE NOT INNOCENT BYSTANDERS: ASSOCIATION WITH CARDIOMYOPATHY, CARDIAC CONDUCTION ABNORMALITIES, AND ARRHYTHMIAS EXIST
Authors: Chad Ward, Lee Joseph, Hardik Doshi, Musab Alqasrawi, Brodie Marthaler, April Shewmake, Zubairu Josiah, Jennifer O’Loughlin Langstengel, Casey Adams, Abraham Sonny, Nicole Worden, Prashant Bhave, Michael Giudici
Journal: Journal of the American College of Cardiology (2016)
Abstract 5252: Sequential biphasic changes in claudin1 and claudin4 expression correlate to colorectal cancer progression and liver metastasis
Authors: Rania Georges, Frank Bergmann, Hassan Adwan, Martin R. Berger
Journal: Cancer Research (2011)

Abstract Terminal progression of colorectal cancer culminates in liver metastasis. To identify genes that are involved in the metastatic phenotype, cDNA microarrays were used to analyze mRNA expression profiles of CC531 rat colon adenocarcinoma cells for changes related to their homing into the liver. Briefly, CC531 cells were intraportally implanted into the liver of Wag-Rij rats and re-isolated after 3, 6, 9, 14 and 21 days. Compared to control CC531 cells, claudin1 and claudin4 were among the ≥8 fold initially down-regulated genes. The co-culture of tumor cells with isolated rat hepatocytes and Kupffer cells did not induce down-regulation of either claudin1 or 4. When the environment effective on circulating tumor cells was simulated by cell culture conditions favoring their adhesion, only claudin4 showed augmented expression. Knockdown of claudin1 and claudin4 mediated by siRNA caused significantly increased migration and decreased clonogenic growth of tumor cells (p&amp;lt;0.05), but had no effect on their proliferation. These experimental results were paralleled by increased claudin1 and claudin4 expression in human colorectal cancer samples in UICC stages l-lll, as evaluated by real-time PCR. Increased claudin4 levels were correlated with significantly reduced overall survival (log-rank test, p=0.018). Further, significantly (p&amp;lt;0.05) reduced expression of claudin1 and claudin4 was observed in stage IV and liver metastasis by immunohistochemistry. In conclusion, sequential biphasic changes in claudin1 and claudin4 expression occur during the homing of colorectal cancer cells to the liver. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5252. doi:10.1158/1538-7445.AM2011-5252
Solitary Occult Retention Cysts of the Pancreas
Authors: George L. Nardi, David C. Lyon, Harry J. Sheiner, Marshall K. Bartlett
Journal: New England Journal of Medicine (1969)

Eight patients with long standing intermittent abdominal pain were found to have solitary cysts in the head of the pancreas. These cysts were demonstrated by retrograde pancreatography but could not be either visualized or palpated at operation. In only two cases was there sufficient clinical evidence to make a diagnosis of pancreatitis; in the remaining six the demonstration of a cyst was the first evidence of any abnormality that could account for their symptoms. All patients were treated by sphincteroplasty. Biopsy of the ampulla revealed fibrosis or inflammation in four of the seven patients in whom biopsy was performed. There was one postoperative death, and there has been little discernible relief in the case associated with alcoholism. The remaining six patients have had symptomatic relief for one to five years.
SAT0117 Early RA patients reporting a flare identify more tender than swollen joints:
Authors: V.P. Bykerk, S.J. Bartlett, E. Choy, G. Boire, C. Hitchon, J. Pope, C. Thorne, B. Haraoui, E. Keystone, C.O. Bingham
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> To better enable a better understanding of disease worsening or flare (F) in Rheumatoid Arthritis (RA) core domains for assessment of flare have been identified by patients (pts) and health care professionals through Delphi exercises. Two of these include patient (pt) identification of swollen and tender joints<sup>1</sup>. <h3>Objectives</h3> To evaluate concordance between patient and rheumatologist assessments of swollen and/or tender joints during flare in early RA. <h3>Methods</h3> Patients in Canadian early ArThritis CoHort (CATCH) completed the OMERACT preliminary flare questionnaire (PFQ) at study visits between 11-2011and 01- 2012. Pts self assessments of number of tender and swollen joints (42 joints – tender and swollen) were compared with joint counts routinely conducted by their rheumatologists (at same visit). <h3>Results</h3> 263 CATCH pts completed the PFQ during the study period. 30% (79) reported a flare (F). Mean age (SD) in F group (gp) was 52.3 (16.6); 77% were female, 68.4% were RF+. Patients reported significantly higher tender joint counts than those reported by their rheumatologists for all 42 joints, 10 large joints and upper extremity joints (Table). There was a trend (p=0.08) for higher patient swollen joint counts for all 42 joints; other differences between patients and providers for swollen joints were not statistically significant. <h3>Conclusions</h3> In patients with early RA, pt and MD SJCs were similar, but pts reported a higher number of affected joints. Differences in SJCs between groups were not statistically significant. These data highlight that ERA pts in a flare are aware of their joint involvement. Patient joint counts need to be considered in measures looking at worsening of disease activity. <h3>References</h3> Bartlett SJ, et al.Arthritis Rheum 2011;63(suppl):128 <h3>Disclosure of Interest</h3> None Declared
IMPACT OF DIABETES MELLITUS ON THE PREDICTIVE VALUE OF CARDIAC I-123 METAIODOBENZYLGUANIDINE IMAGING ON MODE OF DEATH IN PATIENTS WITH CHRONIC HEART FAILURE
Authors: Shunsuke Tamaki, Takahisa Yamada, Takashi Morita, Yoshio Furukawa, Yusuke Iwasaki, Masato Kawasaki, Atsushi Kikuchi, Takumi Kondo, Tsutomu Kawai, Satoshi Takahashi, Masashi Ishimi, Hideyuki Hakui, Tatsuhisa Ozaki, Yoshihiro Sato, Masahiro Seo, Masatake Fukunami
Journal: Journal of the American College of Cardiology (2015)