tbuckley/cabot-search huggingface dataset:
Abstract A19: Role of NF-κB and gene targets of NF-κB in glioma cell plasticity
Authors: Dinorah Friedmann-Morvinski, Rajesh Narasimamurthy, Yifeng Xia, Chad Myskiw, Yasushi Soda, Inder M. Verma
Journal: Cancer Research (2015)

Abstract Glioblastoma (GBM) is the most common and lethal form of intracranial tumor. In the last century we have accumulated tremendous amounts of data on this type of cancer, but despite extensive study, few therapeutic targets have been identified for GBM. We have established a lentiviral-induced mouse model of malignant gliomas, which faithfully captures the pathophysiology and molecular signatures of human GBM. RNAseq analysis of these tumors revealed high NFκB activation showing enrichment of known NFκB target genes. Depletion of IKK2 in tumor derived cell lines attenuated tumor proliferation and prolonged mouse survival. We have previously shown that gliomas can originate by reprograming/dedifferentiation of terminally differentiated astrocytes and neurons following oncogenic insult. This tumor cell plasticity seems to be impaired when either cortical astrocytes or neurons derived from floxed-IKK2 mice are infected with a lentivirus expressing HRAS-iresCREerT2-shp53. The addition of tamoxifen to the infected cells induces IKK2 depletion and blocks the reprogramming process, manifested by inhibition of tumorspheres formation and retention of differentiation makers. When these cells are transplanted into mice, the control group (vehicle treated) succumbs to the disease, while induction of IKK2 depletion in the tamoxifen treated group (20 days post-transplantation) significantly prolonged the mice survival. Activation of NFκB requires the activity of IκB kinase (IKK) complex containing IKKα and IKKβ, and the regulatory protein NFκB essential modifier (NEMO). We tested a peptide corresponding to the NEMO-binding domain (NBD) of IKKα(IKK1) or IKKβ(IKK2), to specifically inhibit the induction of NFκB activation, and the mice treated with NBDwt peptide showed long-term survival compared to NBDmut control. We propose targeting the NFκB pathway as an attractive therapeutic strategy to treat GBM. Citation Format: Dinorah Friedmann-Morvinski, Rajesh Narasimamurthy, Yifeng Xia, Chad Myskiw, Yasushi Soda, Inder M. Verma. Role of NF-κB and gene targets of NF-κB in glioma cell plasticity. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr A19.
Abstract IA04: Cancer-associated systemic inflammation facilitates breast cancer metastasis
Authors: Seth B. Coffelt, Kelly Kersten, Max Wellenstein, Chris W. Doornebal, Camilla Salvagno, Kim Vrijland, Cheei-Sing Hau, Jos Jonkers, Karin E. de Visser
Journal: Cancer Research (2016)

Abstract Over 90% of breast cancer deaths are due to complications as a consequence of metastasis formation. Despite its devastating effects, metastatic disease is still poorly understood. Accumulating evidence indicates that cells and mediators of the immune system influence metastasis formation. In our lab, we use preclinical mouse models for metastatic breast cancer to dissect the impact of the immune system on the different steps of the metastatic cascade. Neutrophils make up a significant proportion of the inflammatory infiltrate in many tumors and their systemic accumulation in cancer patients has been associated with metastasis formation. Also in our recently developed spontaneous breast cancer metastasis mouse model that accurately mimics each step of the metastatic cascade in humans, metastasis formation is accompanied by pronounced systemic accumulation of neutrophils. Antibody-mediated depletion of neutrophils did not affect primary breast cancer outgrowth, but profoundly decreased spontaneous metastasis formation in lungs and lymph nodes. Using biological and genetic approaches, we have uncovered a novel mammary tumor-induced systemic communication network between gamma delta T cells and neutrophils that is critical for breast cancer metastasis. Our data indicate that targeting this novel cancer cell-initiated systemic inflammatory cascade represents a viable strategy to inhibit metastatic disease. Citation Format: Seth B. Coffelt, Kelly Kersten, Max Wellenstein, Chris W. Doornebal, Camilla Salvagno, Kim Vrijland, Cheei-Sing Hau, Jos Jonkers, Karin E. de Visser. Cancer-associated systemic inflammation facilitates breast cancer metastasis. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA04.
Benefit and risks of trivalent 2010 seasonal influenza vaccine in Australian children
Authors: R Lopert
Journal: Eurosurveillance (2010)

Preview this article: Benefit and risks of trivalent 2010 seasonal influenza vaccine in Australian children, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/40/art19679-en-1.gif
Pleural Effusion
Authors: Richard W Light
Journal: New England Journal of Medicine (2002)

A 70-year-old man with an 80-pack-year history of smoking and a history of congestive heart failure presents with increasing shortness of breath. He also has aching chest pain on the right side that worsens with deep inspiration. He is afebrile. The chest radiograph reveals asymmetrical bilateral pleural effusions, with more fluid on the right. How should this patient be evaluated?
Emotion as personal creation: a psychoanalytic and psychological perspective
Authors: G E Warme
Journal: American Journal of Psychiatry (1980)

In their daily work psychotherapists rely on theoretical underpinnings derived from psychoanalysis. Many have come to rely on exaggerations of the notion of abreaction or catharsis, the so-called "expressing of feelings." This notion, implicit in psychoanalytic metapsychology, consists of a substantive, thing-like conception of emotion. Patients are seen as victims of demonic emotions that overwhelm them and compel them to act in various ways and "cause" them to suffer painfully. The author believes that a truly psychoanalytic and psychological perspective views patients as the creators of their emotional behaviors.
MRI and FDG PET/CT Imaging Manifestations of Cardiac Sarcoidosis
Authors: Yang Lu, Nadera J. Sweiss
Journal: Clinical Nuclear Medicine (2015)

A 52-year-old man had biopsy-proven sarcoidosis of mediastinal lymph nodes. Cardiac sarcoidosis was confirmed on cardiac MRI with typical imaging features as delayed gadolinium enhancement. Follow-up FDG PET/CT with a 3-day pretest diet modification showed suppression of overall myocardial uptake of FDG but with multifocal abnormal FDG uptake in the myocardium regions corresponding to the previous MRI findings. Additional noncardiac active sarcoidosis involving multiple organ and lymph nodes were also visualized on FDG PET/CT.
Multicenter clinicopathological correlation in dementia
Authors: J Victoroff, W J Mack, S A Lyness, H C Chui
Journal: American Journal of Psychiatry (1995)

The aim of the present study was to determine the accuracy of clinical diagnoses of dementia in a large group of patients evaluated in a multicenter, university-based, Alzheimer's disease diagnostic and treatment program.Clinical diagnoses and neuropathological results from seven collaborating Alzheimer's disease research centers were compared for 196 cases of dementia.When diagnoses of probable Alzheimer's disease, possible Alzheimer's disease, and Alzheimer's disease plus another condition were combined, 163 (83%) of the patients were clinically regarded as likely to have had Alzheimer's disease. Of those patients, 134 (82%) were found to have neuropathological changes diagnostic of Alzheimer's disease or Alzheimer's disease plus another condition. A total of 116 patients were diagnosed as having probable Alzheimer's disease; 100 (86%) of those were found to have pathological diagnoses of Alzheimer's disease or Alzheimer's disease plus another condition. Cerebral infarcts were found in 17% of the patients clinically diagnosed with probable Alzheimer's disease. Lewy bodies with variable Alzheimer's disease-type pathological changes were found in 7% of the patients with clinical diagnoses of probable Alzheimer's disease. Conversely, significant Alzheimer's disease-type pathological changes were found in 55% of the patients clinically diagnosed as having vascular dementia.Clinicians accurately predict Alzheimer's disease-type neuropathological findings in a high proportion of cases of dementia but may not predict cerebrovascular pathology and Lewy bodies in some patients with apparent clinical Alzheimer's disease and may often fail to predict Alzheimer's disease-type pathological findings in patients with apparent vascular dementia. With the emergence of effective treatments for Alzheimer's disease, there is an increasing need to optimize methods for ante-mortem diagnosis of dementia.
Depression: schism in contemporary psychiatry
Authors: A M D'Agostino
Journal: American Journal of Psychiatry (1975)

The author decribes an experience in his own family involving the initial unsuccessful treatment of a depressed patient. The patient failed to respond to psychotherapeutic and drug treatment on an outpatient basis and in three hospitals; in a fourth hospital he improved dramatically after a series of ECT treatments and remained without depressive symptoms. The author stresses the importance of psychiatrists keeping an open mind about various treatment approaches.
Measuring teaching through hormones and time series analysis: Towards a comparative framework
Authors: Andrea Ravignani, Ruth Sonnweber
Journal: Behavioral and Brain Sciences (2015)

Abstract Arguments about the nature of teaching have depended principally on naturalistic observation and some experimental work. Additional measurement tools, and physiological variations and manipulations can provide insights on the intrinsic structure and state of the participants better than verbal descriptions alone: namely, time-series analysis, and examination of the role of hormones and neuromodulators on the behaviors of teacher and pupil.
Massachusetts Medical Society
Authors: Earle M. Chapman, John D. Stoeckle
Journal: New England Journal of Medicine (1973)

PHYSICIAN EXTRAORDINARY — A FOE OF MAN-MADE DISEASES Dr. Harriet L. Hardy was elected the Massachusetts Medical Society's Orator for 1973, but a long-drawn-out illness, from which she is now recovering, prevented her from accepting the honor. Since Dr. Hardy had to forgo the oratorship, the Society wishes to express its esteem by publishing the following tribute written by two of her friends and colleagues.At the annual meeting in December, 1972, the American Public Health Association recognized the leadership in occupational medicine of Harriet L. Hardy, M.D., by bestowing on her its Centennial Award.Dr. Hardy continues to . . .
Effect of 5-Fluorouracil on Mammary Tumors in Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Elizabeth M. Cranston
Journal: JNCI Journal of the National Cancer Institute (1959)

5-Fluorouracil prevented growth of second- to fourth-generation transplants of a mammary adenocarcinoma in mice. On cessation of therapy or transplantation of treated tumors into untreated animals, growth of tumors occurred. Results obtained in mice with spontaneous tumors suggest that very occasionally 5-fluorouracil may cause regression of such tumors.
lodine-125 and lodine-131 in the Treatment of Hyperthyroidism
Authors: CH GLANZMANN, W HORST
Journal: Clinical Nuclear Medicine (1980)

Indications and results of radioiodine (I-125 and I-131) treatment of hyperthyroidism in more than 2000 patients from 1964 until 1974 are reported. The amount of activity was calculated individually according to the estimated mass of the thyroid, the thyroidal uptake of radioiodine, and the estimated half-life of radioiodine in the thyroid. I-125 has been administered since 1972 only in patients with diffuse hyperthyroidism and a small thyroid gland without nodules. In about 70% of the patients with diffuse hyperthyroidism, a single dose of radioiodine was sufficient and less than 15% needed three or more doses. The cumulative risk of myxedema 9-13 years after treatment with I-131 was about 30%. In patients with small diffuse glands, the cumulative risk of myxedema five years after treatment with I-131 was about 20%, whereas after treatment with I-125 the cumulative risk of myxedema was 10% after five years. In patients with nodular goiter and no signs of ophthalmopathy, the cumulative risk of myxedema 10-13 years after treatment with I-131 was less than 10%. In about 80% of the patients with an autonomous adenoma, a single application of I-131 was sufficient for the elimination of the adenoma. The risk of myxedema after I-131 treatment of an autonomous adenoma is negligible. There was no case of thyroid cancer which arose in a treated autonomous adenoma. An analysis of the efficiency, the risk of myxedema, and the risks of radiation and a comparison with the results and risks of surgical treatment show that treatment with I-131 is the method of choice in the majority of those patients who need an ablative treatment for permanent control of thyrotoxicosis. In a selected group of patients with diffuse hyperthyroidism, we achieved better results with I-125, but because long-term observation of these patients is lacking, we recommend only the use of I-131 for routine radioiodine treatment.
Teen pregnancies fall to record low in England
Authors: Susan Mayor
Journal: BMJ (2016)

Teenage pregnancies have reached a record low in England, suggesting that a national strategy to improve sex education and health services for young people in areas of greatest deprivation has been effective, a study shows.1

In 1999 the government launched a 10 year nationwide teenage pregnancy strategy to reduce conception rates in women under 18, which were much higher in the United Kingdom than in other western European countries. The programme included a national media campaign and improvements in sex education and young people’s sexual health services, with greater support for the local authority areas with the highest teen pregnancy rates.

Researchers …
Erratum to: Network-driven plasma proteomics expose molecular changes in the Alzheimer’s brain
Authors: Philipp A. Jaeger, Kurt M. Lucin, Markus Britschgi, Badri Vardarajan, Ruo-Pan Huang, Elizabeth D. Kirby, Rachelle Abbey, Bradley F. Boeve, Adam L. Boxer, Lindsay A. Farrer, NiCole Finch, Neill R. Graff-Radford, Elizabeth Head, Matan Hofree, Ruochun Huang, Hudson Johns, Anna Karydas, David S. Knopman, Andrey Loboda, Eliezer Masliah, Ramya Narasimhan, Ronald C. Petersen, Alexei Podtelezhnikov, Suraj Pradhan, Rosa Rademakers, Chung-Huan Sun, Steven G. Younkin, Bruce L. Miller, Trey Ideker, Tony Wyss-Coray
Journal: Molecular Neurodegeneration (2016)

Unfortunately, after publication of this article [1], it was noticed that the name of Matan Hofree was misspelled. The corrected name can be seen above and the original article has been updated to reflect this change.
Role of PET/CT Scanning in Initial and Post-Treatment Assessment of Hodgkin Disease
Authors: Sukru Mehmet Erturk, Annick D. Van den Abbeele
Journal: Journal of the National Comprehensive Cancer Network (2008)

The add-on value of F18-fluorodeoxyglucose PET, particularly when combined with CT, to the conventional workup in managing patients with Hodgkin disease has now been well documented. This article reviews the use of these imaging modalities in the initial staging and post-treatment assessment of Hodgkin disease.
Comparative side effects of imipramine, benztropine, or their combination in patients receiving fluphenazine decanoate
Authors: S G Siris, A Rifkin, G T Reardon, M November
Journal: American Journal of Psychiatry (1983)

Patients receiving fluphenazine decanoate who were switched from adjunctive benztropine to imipramine in a double-blind trial experienced marked exacerbations of extrapyramidal side effects. No substantial increase in anticholinergic side effects occurred, however, when imipramine was added to fluphenazine decanoate and benztropine.
The Role of Hormones in Liver Careinogenesis&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;, &lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: A. Clark Griffin, Howard L. Richardson, Charles H. Robertson, Margery A. O'Neal, James D. Spain
Journal: JNCI Journal of the National Cancer Institute (1955)

The Role of Hormones in Liver Careinogenesis, Get access A. Clark Griffin, A. Clark Griffin Department of Chemistry, Stanford University, Calif., and Sloan-Kettering Institute for Cancer Research, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard L. Richardson, Howard L. Richardson Department of Chemistry, Stanford University, Calif., and Sloan-Kettering Institute for Cancer Research, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles H. Robertson, Charles H. Robertson Department of Chemistry, Stanford University, Calif., and Sloan-Kettering Institute for Cancer Research, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margery A. O'Neal, Margery A. O'Neal Department of Chemistry, Stanford University, Calif., and Sloan-Kettering Institute for Cancer Research, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar James D. Spain James D. Spain Department of Chemistry, Stanford University, Calif., and Sloan-Kettering Institute for Cancer Research, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue Supplement_5, April 1955, Pages 1623–1632, https://doi.org/10.1093/jnci/15.Supplement_5.1623 Published: 01 April 1955
Treatment Indications for Antidepressants Prescribed in Primary Care in Quebec, Canada, 2006-2015
Authors: Jenna Wong, Aude Motulsky, Tewodros Eguale, David L. Buckeridge, Michal Abrahamowicz, Robyn Tamblyn
Journal: JAMA (2016)

This pharmacoepidemiology study uses national Canadian electronic medical record data to describe treatment indications for antidepressants and temporal trends in antidepressant prescribing for depression in Quebec, Canada, from 2006 through 2015.
Enhanced Recovery After Robot-assisted Radical Cystectomy: EAU Robotic Urology Section Scientific Working Group Consensus View
Authors: Justin W. Collins, Hiten Patel, Christofer Adding, Magnus Annerstedt, Prokar Dasgupta, Shamim M. Khan, Walter Artibani, Richard Gaston, Thierry Piechaud, James W. Catto, Anthony Koupparis, Edward Rowe, Matthew Perry, Rami Issa, John McGrath, John Kelly, Martin Schumacher, Carl Wijburg, Abdullah E. Canda, Meviana D. Balbay, Karel Decaestecker, Christian Schwentner, Arnulf Stenzl, Sebastian Edeling, Sasa Pokupić, Michael Stockle, Stefan Siemer, Rafael Sanchez-Salas, Xavier Cathelineau, Robin Weston, Mark Johnson, Fredrik D’Hondt, Alexander Mottrie, Abolfazl Hosseini, Peter N. Wiklund
Journal: European Urology (2016)
Cancer in Africa, Especially in Regions South of the Sahara&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: A. G. Oettlé
Journal: JNCI Journal of the National Cancer Institute (1964)

Striking differences are noted in cancer incidence, situation, and histopathological type between and within races of Africa. These suggest that 80 percent or more of the cancers affecting western races are environmentally induced and potentially preventable. Negriform races generally have a much lower incidence than western races or U.S. non-whites, which disposes of the hypothesis of the uniform liability of mankind to cancer. The gradual assumption of a western manner of life by African races has resulted in the availability for study of material from these vast human experiments. Among the Negriform races, cancers of stomach, large bowel, breast, endometrium, ovary, brain, and leukemia are generally rare. Common to them are primary cancer of the liver, Kaposi's sarcoma, Burkitt's tumor, and, in some regions, esophageal cancer. The mixed race (Colored) has a high rate of stomach and liver cancer. Asians have a lower mortality. South African whites resemble U.S. whites, except for higher rates for lip, tongue, stomach, prostate, skin, and bone cancers. Etiological aspects of individual tumors are discussed with regard to lip (tobacco and sunlight), mouth, postnasal space, esophagus, liver (fungal toxins?), sinuses (snuff), lung (smoking, arsenic), mesothelium (asbestos), uterus, penis (circumcision, ablution), bladder (bilharziasis), prostate, skin (sunlight, tropical ulceration, other ulcers), eye, conjunctiva (sunlight), brain, and lymphomas. Since most cases of cancer in Africa are out of reach of methods of treatment other than chemotherapy, great need as well as opportunities exist for the study of carcinostatics.
Preliminary report: outbreak of Legionnaires’ disease in the cities of Ulm and Neu-Ulm in Germany, December 2009 - January 2010
Authors: H von Baum, G Härter, A Essig, C Lück, T Gonser, A Embacher, S Brockmann
Journal: Eurosurveillance (2010)

Currently an investigation is ongoing to explore and control an outbreak of Legionnaires disease, affecting 65 people as of 22 January 2010, in the cities of Ulm and Neu-Ulm, south-west Germany. A hitherto unidentified wet cooling system in these twin cities is considered as the most likely source of infection.
A five-year study of brief hospitalization
Authors: M Swartzburg, A Schwartz
Journal: American Journal of Psychiatry (1976)

The authors compare their experience with 4 years on a brief hospitalization unit based on crisis theory with a fifth year on the same unit based on a traditional psychiatric approach. In terms of demographic and diagnostic variables and rehospitalization rates, they found that the change in approach had no significant effect on the type of patient admitted or the treatment outcome. The fact that certain tasks necessary for rapid discharge were effectively performed accounted for the success of the unit.
Venous Thromboembolism Prevention in Cancer Outpatients
Authors: Alok A. Khorana
Journal: Journal of the National Comprehensive Cancer Network (2013)

Venous thromboembolism (VTE) has serious consequences for patients with cancer, including mortality. VTE is preventable with appropriate thromboprophylaxis, but prior public health efforts have focused on prophylaxis in the inpatient setting. However, most VTE events in malignancy currently occur in outpatients. Several recent clinical trials have addressed thromboprophylaxis in the ambulatory setting. Their findings suggest potential benefit, but with significant variation in underlying risk. A risk-adapted approach that incorporates risk of thrombosis, risk of bleeding, and patient preference can target high-risk patients and also allow low-risk patients to avoid prophylaxis. Risk assessment is therefore key to patient selection for outpatient prophylaxis. This article focuses on results of recent trials and updates from major guideline panels, with the intent of providing guidance to clinical providers.