tbuckley/cabot-search huggingface dataset:
Need for a National Evaluation System for Health Technology
Authors: Jeffrey Shuren, Robert M. Califf
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Can Stereotactic Body Radiotherapy Really Be Considered the Preferred Treatment in Large Hepatocellular Carcinoma?
Authors: Berardino De Bari, Mahmut Ozsahin, Pierre Bize, Tarek Boussaha, Gaël Deplanque, Dorothea Wagner, Jean Bourhis, Alban Denys
Journal: Journal of Clinical Oncology (2016)
Modified Framingham Risk Score predicted 10-y CAD better than the original score in patients with lupus
Authors: David S. Pisetsky
Journal: Annals of Internal Medicine (2016)

ACP Journal Club21 June 2016Modified Framingham Risk Score predicted 10-y CAD better than the original score in patients with lupusDavid S. Pisetsky, MD, PhDDavid S. Pisetsky, MD, PhDDuke University Medical Center, Durham, North Carolina, USA (D.S.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2016-164-12-071 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationUrowitz MB, Ibañez D, Su J, Gladman DD. Modified Framingham Risk Factor Score for systemic lupus erythematosus. J Rheumatol. 2016;43:875-9. https://pubmed.ncbi.nlm.nih.gov/26879352Clinical Impact RatingsGIM/FP/GP: Rheumatology: References1 Yazdany J, Feldman CH, Liu J, et al. Quality of care for incident lupus nephritis among Medicaid beneficiaries in the United States. Arthritis Care Res (Hoboken). 2014;66:617-24. [PMID: 24124011] Google Scholar2 Parker B, Bruce I. SLE and metabolic syndrome. Lupus. 2013;22:1259-66. [PMID: 24097998] Google Scholar3 Costenbader KH, Karlson EW, Gall V, et al. Barriers to a trial of atherosclerosis prevention in systemic lupus erythematosus. Arthritis Rheum. 2005;53:718-23. [PMID: 16208639] Google Scholar Author, Article, and Disclosure InformationAffiliations: Duke University Medical Center, Durham, North Carolina, USA (D.S.P.)This article was published at Annals.org on 7 June 2016. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byAssociation between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease 21 June 2016Volume 164, Issue 12Page: JC71KeywordsCohort studiesHigh density lipoproteinInflammationLupus erythematosusMedical risk factorsMetabolic syndromeMyocardial infarctionPopulation statisticsRheumatologyStable coronary artery disease ePublished: 21 June 2016 Issue Published: 21 June 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
P-207 Protective Effect of Ursodeoxycholic acid in the Chemotherapy Induced Mucositis
Authors: H.J. Chun, S.H. Kim, J.M. Lee, I.K. Yoo, J.M. Lee, H.S. Choi, E.S. Kim, B. Keum, Y.T. Jeen, H.S. Lee, C.D. Kim
Journal: Annals of Oncology (2016)
Massachusetts Medical Society
Authors: John F. Conlin
Journal: New England Journal of Medicine (1948)

MASSACHUSETTS MEDICINE AND THE ANIMALAntivivisectionism has flourished in Massachusetts for many years. All the requirements for such a situation prevail in eminent degree within the Commonwealth. We have three medical schools, an antivivisection society or two and no less than three Hearst newspapers.Repeated and often frenzied efforts to obtain the passage of legislation restricting or abolishing animal experimentation have been defeated. With the type of intelligent lawmaker now prevailing on Beacon Hill it can be safely stated that antivivisectionist legislation will continue to be defeated.Experimental animals, never adequate in number, have been increasingly difficult to obtain. Important . . .
NEW HOSPITAL STAPHYLOCOCCI
Authors: F A KINGERY
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes of weight and body composition after gastrectomy in the elderly gastric cancer patients.
Authors: Kenki Segami, Toru Aoyama, Yukio Maezawa, Kazuki Kano, Tsutomu Sato, Takashi Ogata, Haruhiko Cho, Takaki Yoshikawa
Journal: Journal of Clinical Oncology (2016)

89 Background: Body weight, especially lean body mass, significantly reduces after gastrectomy for gastric cancer due to surgical invasion, reduced food intake, or decreased mobility, which could decrease quality of life and toxicity / compliance of adjuvant chemotherapy. These risks might be high especially in the elderly gastric cancer patients. However, it remains unclear whether changes of weight and body composition are different between the elderly and the non-elderly. Methods: This retrospective study examined patients who underwent curative surgery for gastric cancer between June 2010 and March 2014. Body weight and composition were evaluated by a bioelectrical impedance analyzer within 1 week before surgery (first measurement), at 1 week after surgery (second measurement), at 1 month after surgery (third measurement), and at 3 months after surgery (forth measurement). Patients were classified to the elderly (&gt; 75 years) and the non-elderly ( &lt; 75 years). Results: Four-hundred forty three patients (100 for the elderly and 343 for the non-elderly) were entered in the present study. Patients backgrounds, surgical factors, clinicopathological factors, surgical complications and adjuvant chemotherapy were not significantly different between the two groups. %Body weight loss until 1week, 1month, 3 months after surgery, defined as the proportion of the difference between 1 st measurement and each measurement after surgery against 1 st measurement, was 3.3%, 6.6%, and 9.7%, respectively in the elderly and 3.7%, 5.4%, and 8.2%, respectively in the non-elderly with significant difference (p = 0.05, 0.01, and 0.01, respectively). %Lean body mass loss until 1 week, 1 month, 3 months after surgery was 3.2%, 5.6%, and 6.1%, respectively in the elderly and 3.2%, 4.5%, and 4.2%, respectively in the non-elderly with p value of 0.36, 0.08, and 0.01, respectively. %Fat loss was not significantly different between the two groups at any time. Conclusions: Decreases in body weight and lean body mass after gastrectomy were more serious in the elderly patients as compared with the non-elderly. Surgical indication for the elderly must be carefully determined considering the risk and the benefit.
Interleukin 25 Receptor Expression on Airway Dendritic Cells After Allergen Challenge in Asthmatic Subjects.
Authors: Damian Tworek, Steven G. Smith, Brittany M. Salter, Adrian J. Baatjes, Tara Scime, Rick Watson, Caitlin Obminski, Gail M. Gauvreau, Paul M. O'Byrne
Journal: American Journal of Respiratory and Critical Care Medicine (2015)

Abstract Interleukin (IL)-25 is an epithelial-derived cytokine, whose effects are mediated by the IL-25 receptor (IL-17RB), and which has been implicated in the pathogenesis of allergic disease and airway viral responses. Airway myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs) are professional antigen-presenting cells. pDCs may play a protective role in asthma and are key players in the innate immune response through recognition of microbial products via Toll-like receptors (TLR). The effects of inhaled allergens on the expression of IL-17RB by mDCs and pDCs, as well as the effects of IL-25 on pDCs, are unknown. To evaluate allergen-induced changes in IL-17RB expression by mDCs and pDCs and to investigate the effects of IL-25 on pDCs. Patients with mild atopic asthma (n=13) were challenged with inhaled allergen. Blood and sputum DCs were enumerated and IL17-RB expression was determined by flow cytometry before, 7 and 24 hours after allergen challenge. The effects of IL-25 on pDCs in vitro were also assessed. Inhaled allergen significantly increased both mDC and pDC numbers in sputum, but not in blood. The percentage of IL-17RB+ mDCs and pDCs was significantly increased in both blood and sputum, 24 hours after challenge. IL-25 up-regulated TLR9 expression by pDCs and orchestrated the responses to TLR9 ligation. IL-17RB is upregulated on blood and sputum mDCs and pDCs after allergen inhalation. IL-25 modulates pDC function through an effect on TLR9 expression.
Metabolism of N&lt;sup&gt;15&lt;/sup&gt;-Labeled &lt;italic&gt;p&lt;/italic&gt;-Dimethylphenylenediamine in Rats&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Julius White, Harriett T. Cool, Ruth S. Stander, Philip W. David
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Metabolism of N15-Labeled p-Dimethylphenylenediamine in Rats Get access Julius White, Julius White National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Harriett T. Cool, Harriett T. Cool National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruth S. Stander, Ruth S. Stander National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Philip W. David Philip W. David National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 529–537, https://doi.org/10.1093/jnci/15.3.529 Published: 01 December 1954 Article history Received: 08 September 1954 Published: 01 December 1954
On the origin of tissue slices
Authors: Henricus AM Mutsaers
Journal: BMJ (2016)

My phone vibrates noisily on the table in front of me, interrupting the PhD student presenting her latest experimental data. My colleagues look at me expectantly.

“Hello?”

“Absolutely. Which theatre?”

“Great, thanks for calling.”

The call ends and I declare to nobody in particular: “Liver in theatre 21, I’ll go and pick …
Diastasis recti abdominis during pregnancy and 12 months after childbirth: prevalence, risk factors and report of lumbopelvic pain
Authors: Jorun Bakken Sperstad, Merete Kolberg Tennfjord, Gunvor Hilde, Marie Ellström-Engh, Kari Bø
Journal: British Journal of Sports Medicine (2016)

Diastasis recti abdominis (DRA) is defined as a separation of the 2 muscle bellies of rectus abdominis. To date there is scant knowledge on prevalence, risk factors, and consequences of the condition. The present study aimed to investigate the prevalence of DRA during pregnancy and post partum, presence of possible risk factors, and the occurrence of lumbopelvic pain among women with and without DRA.This prospective cohort study followed 300 first-time pregnant women from pregnancy till 12 months post partum. Data were collected by electronic questionnaire and clinical examinations. DRA was defined as a palpated separation of ≥2 fingerbreadths either 4.5 cm above, at or 4.5 cm below the umbilicus. Women with and without DRA were compared with independent samples Student's t-test and χ(2)/Fisher exact test, and OR with significance level >0.05.Prevalence of DRA was 33.1%, 60.0%, 45.4%, and 32.6% at gestation week 21, 6 weeks, 6 months and 12 months post partum, respectively. No difference in risk factors was found when comparing women with and without DRA. OR showed a greater likelihood for DRA among women reporting heavy lifting ≥20 times weekly (OR 2.18 95% CI 1.05 to 4.52). There was no difference in reported lumbopelvic pain (p=0.10) in women with and without DRA.Prevalence of mild DRA was high both during pregnancy and after childbirth. Women with and without DRA reported the same amount of lumbopelvic pain 12 months post partum.
Case 24-1973
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, J. Warren Harthorne, Benjamin Castleman
Journal: New England Journal of Medicine (1973)

Presentation of Case First admission. A 58-year-old woman was admitted to the hospital because of aortic stenosis.At the age of 25 years she was informed of a heart murmur. She was well until six months before admission, when there was the onset of exertional chest pain that was relieved at rest. Easy fatigability developed and progressed in severity during the three months before entry. Six days before admission, while hurrying, she experienced pain in the chest and lost consciousness for 20 minutes. On admission to another hospital no evidence of myocardial infarction was found. Severe calcific aortic stenosis . . .
Final Results of a Phase II Study Evaluating Lenalidomide in Combination with Low Dose Dexamethasone As First Line Therapy for Primary Plasma Cell Leukemia
Authors: Pellegrino Musto, Fiorella D'Auria, Maria Teresa Petrucci, Anna Levi, Nicola Cascavilla, Antonietta Falcone, Francesco Di Raimondo, Maide Cavalli, Tommaso Caravita, Fortunato Morabito, Massimo Offidani, Nunzio Filardi, Francesco Nobile, Giulia Benevolo, Giuseppe Pietrantuono, Maria Carmen Martorelli, Oreste Villani, Roberto Guariglia, Giovanna Mansueto, Giovanni D'Arena, Rosa Lerose, Antonia Zonno, Emanuela Zifarone, Valentina Santopietro, Katia Todoerti, Sara Bringhen, Francesca Gay, Paola Omedè, Antonino Neri, Mario Boccadoro, Antonio Palumbo
Journal: Blood (2011)
Impact of Major Orthopedic Surgery On Regulatory CD4+ T Lymphocytes and Cytokines in Transfused and Non-Transfused Patients.
Authors: Luciana de Andrade Pereira, Otávio Cesar Carvalho Guimarães Baiocchi, Joyce M. K. Silva, Akemi Kuroda Chiba, Edmilson T Takata, Priscilla B Silva, Akira Ishida, Jose Orlando Bordin
Journal: Blood (2012)
Psychological induction into the large-group: findings from a modern religious sect
Authors: M Galanter
Journal: American Journal of Psychiatry (1980)

The author studied the psychological aspects of religious conversion during structured 21-day workshop sequences designed to introduce people to the Unification Church. Subjects were given a battery of tests at different times during the sequence. After the initial 2-day workshop, 71% dropped out; the 29% who chose to continue had greater affiliative feelings toward the group and greater acceptance of the church's creed than these early dropouts. The 9% who ultimately joined the church had weaker outside personal ties than the later dropouts, although their beliefs in and cohesiveness toward the church were the same as the late dropouts. These results are also compared with long-standing members of the church and matched nonmembers. The induction procedures used by the church are discussed with regard to those used by large therapeutic groups, such as self-help organizations.
Development of a DNA-Based Targeted Assay Suitable for Accurate Quantification of Chromosomal Deletions in Myelodysplastic Syndromes with Deletion (5q) and Other Clonal Diseases
Authors: Johann-Christoph Jann, Daniel Nowak, Florian Nolte, Stephanie Fey, Verena Nowak, Julia Obländer, Jovita Pressler, Alice Fabarius, Claudia Haferlach, Hind Medyouf, Wolf-Karsten Hofmann, Maximilian Mossner
Journal: Blood (2014)
Long-term biocompatibility, imaging appearance and tissue effects associated with delivery of a novel radiopaque embolization bead for image-guided therapy
Authors: Karun V. Sharma, Zainab Bascal, Hugh Kilpatrick, Koorosh Ashrafi, Sean L. Willis, Matthew R. Dreher, Andrew L. Lewis
Journal: Biomaterials (2016)

The objective of this study was to undertake a comprehensive long-term biocompatibility and imaging assessment of a new intrinsically radiopaque bead (LC Bead LUMI™) for use in transarterial embolization. The sterilized device and its extracts were subjected to the raft of ISO10993 biocompatibility tests that demonstrated safety with respect to cytotoxicity, mutagenicity, blood contact, irritation, sensitization, systemic toxicity and tissue reaction. Intra-arterial administration was performed in a swine model of hepatic arterial embolization in which 0.22–1 mL of sedimented bead volume was administered to the targeted lobe(s) of the liver. The beads could be visualized during the embolization procedure with fluoroscopy, DSA and single X-ray snapshot imaging modalities. CT imaging was performed before and 1 h after embolization and then again at 7, 14, 30 and 90 days. LC Bead LUMI™ could be clearly visualized in the hepatic arteries with or without administration of IV contrast and appeared more dense than soluble contrast agent. The CT density of the beads did not deteriorate during the 90 day evaluation period. The beads embolized predictably and effectively, resulting in areas devoid of contrast enhancement on CT imaging suggesting ischaemia-induced necrosis nearby the sites of occlusion. Instances of off target embolization were easily detected on imaging and confirmed pathologically. Histopathology revealed a classic foreign body response at 14 days, which resolved over time leading to fibrosis and eventual integration of the beads into the tissue, demonstrating excellent long-term tissue compatibility.
Endoscopic radial incision and cutting method for refractory stricture of a rectal anastomosis after surgery
Authors: Keita Harada, Seiji Kawano, Sakiko Hiraoka, Yoshiro Kawahara, Yoshitaka Kondo, Hiroyuki Okada
Journal: Endoscopy (2015)

Benign colorectal strictures occur mainly as a result of surgical resection [1]. Especially when a stricture is located in the rectum, it may cause severe symptoms, for which several therapeutic options are available: endoscopic balloon dilation (EBD) [2], placement of a self-expandable metal stent [3], revisional surgery, and palliative colostomy. However, the best treatment has yet to be determined.
Confirmatory Testing for Onychomycosis—Reply
Authors: Anar Mikailov, Cara Joyce, Arash Mostaghimi
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Use of genetic variants in immune response genes to predict clinical outcome in mCRC patients treated with cetuximab-based therapy.
Authors: Anne Maria Schultheis, Nico Benjamin Volz, Wu Zhang, Dongyun Yang, Yan Ning, Sebastian Stintzing, Takeru Wakatsuki, Rita Elie El-Khoueiry, Joseph Ethan Li, Adel Kardosh, Afsaneh Barzi, Anthony B. El-Khoueiry, Heinz-Josef Lenz
Journal: Journal of Clinical Oncology (2013)

3567 Background: Cetuximab is a monoclonal antibody targeting the EGF receptor. One of its anti-tumor mechanisms is the stimulation of the immune system via ADCC (Antibody-Dependent-Cell mediated Cytotoxicity). Immune response through T-cell activation may also play a role in antitumor efficacy of chemotherapy. CTLA4, PDL1, IDO1 and CD24 are inhibitory co-receptors or ligands that may downregulate the immune system through suppression of T-cell response. We tested whether Germline polymorphisms in these genes are involved in the cetuximab dependent immune response pathway and thus predict outcome in mCRC patients treated with cetuximab. Methods: DNA was isolated from blood of 108 patients with mCRC treated with either irinotecan+cetuximab (n=73) or single agent cetuximab (n=35). Twelve prospectively functionally relevant SNPs; IDO1(rs9657182, rs3739319, rs1010866), PD1(rs2227981, rs7421861), PDL1(rs2297137, rs2297136, rs10122089, G&gt;C), CTLA4(rs231777, rs231775), and CD24(rs8734) were analyzed by PCR-based direct sequencing and evaluated for association with tumor response, overall survival (OS), and progression free survival (PFS). Results: Results are attached. There were 65 men and 43 women with a median PFS of 3.7 (95%CI: 2.8, 4.6) months and a median OS of 10.5 (95%CI:7.7, 13.3) months. Median follow up was 16.3 (range:1.2, 42.4) months. Conclusions: Our results show that immune response related SNPs may predict efficacy of cetuximab treatment in patients with mCRC. To the best of our knowledge this is the first data linking PDL1(rs2297137) to cetuximab efficacy in mCRC patients. [Table: see text]