SAT0207 Reading of the Sacroiliac Joints on Plain Radiographs: Agreement between Clinical Practice and Trained Central Reading of the Desir-Cohort
Authors: R. van den Berg, G. Lenczner, A. Feydy, D. van der Heijde, M. Reijnierse, A. Saraux, A. Rahmouni, M. Dougados, P. Claudepierre
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> In daily practice, radiologists/rheumatologist judge sacroiliac (SI) joints on X-rays (X-SI). However, reliable identification of radiographic sacroiliitis is difficult. Consequently, large inter- and intra-observer variations have been reported, even after specific training<sup>1</sup>. In cohorts and clinical trials the reading is usually done by ≥1 trained readers. However, in the DEvenir des Spondylarthropathies Indifferenciées Récentes (DESIR)-cohort, X-SIs at inclusion were first read by the local radiologist/rheumatologist, then by centralized read. <h3>Objectives</h3> To compare the local (by multiple readers in various centers) to centralized read (by a few trained readers) on sacroiliitis yes/no. <h3>Methods</h3> Patients (pts) aged 18-50 with inflammatory back pain (IBP; ≥3 months, ≤3 years) from 25 participating centers were included in the DESIR-cohort (n=708). Available baseline X-SIs were read by local radiologists/rheumatologists with access to clinical data, according to a method derived from the modified New York (mNY) criteria<sup>2</sup>. Grade 2 and 3 from the mNY were pooled together in 1 combined grade "DESIR-2". Local sacroiliitis was defined by at least unilateral grade ≥DESIR-2. Next, 2 well-calibrated centralized readers independently read all X-SIs according to the original mNY, blinded for clinical data. In case of disagreement, an experienced radiologist was adjudicator. An X-SI was marked positive if 2/3 readers agreed on bilateral ≥2 or unilateral ≥3. Agreement between the 2 centralized readers, and between the local and centralized read was calculated (Kappa; % agreement). <h3>Results</h3> Pts with complete X-SI data (n=689) were included in this analysis. Inter reader agreement between the 2 centralized readers is moderate (Kappa 0.54), while percentage agreement (84.3%) is good (table). The low Kappa can partially be explained by the high numbers of normal X-SIs. However, the adjudicator needed to read 108/689 X-SIs (15.7%) because of disagreement among the 2 centralized readers. Comparison between the centralized and the local read shows similar levels of agreement (table). Overall, more X-SIs are read positive by local readers (n=184) than by centralized readers (n=145). In 77 pts, X-SI was read positive by local readers but negative by centralized read; in 38 pts it was the other way around. <h3>Conclusions</h3> Agreement between the centralized and local read, but also the inter reader agreement between the 2 centralized readers, is moderate, thereby showing that early detection of sacroiliitis on X-SIs is a challenge. In patients with recent onset IBP, trained readers do not perform better than local rheumatologists/radiologists in recognizing sacroiliitis on X-SI, suggesting that the role of X-SI as diagnostic criterion for axSpA should be re-evaluated. <h3>References</h3> van Tubergen ARD 2003;62:519-25. van der Linden A&amp;R 1984;27:361–8. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2131