tbuckley/cabot-search huggingface dataset:
Abstract 4225: A novel pharmacological inhibitor CEP1430 for human pancreatic cancer stem cells
Authors: Jitesh Jani, Mandana Amiri, Cristian Sharma, Joshua Harris, Shruthi Satish, Michael Sharma, Robert Rodriguez, Miriam Navel, Natalee Amezcua, Shaleekha Sharma, Arun Sharma, Dhimant Desai, Shantu Amin, Satya Narayan, Rubio Punzalan, Jay P. Sharma
Journal: Cancer Research (2015)

Abstract Pancreatic cancer is one of the most devastating human malignancies with an estimate yearly death of 280,000 and an overall median 5-year survival rate of less than 5%. The development of relevant preclinical models of the disease to evaluate novel therapeutic strategies can accelerate basic research findings into the much needed clinical application. We used our recently established three-dimensional (3D) in vitro culture assay system that resembles in-vivo tumor growth to screen small molecule libraries. We identified CEP1430, a sonic hedgehog (hh) pathway inhibitor as a potential drug lead molecule. We selected this molecule for further evaluation because the hh pathway is important for the maintenance of cancer stem cells. The CEP1430 treatment markedly inhibited in-vitro growth of human pancreatic CSC (IC50 value of ∼10 nM). In-vitro, CEP1430 induced apoptotic cell death of CSC and reduced pro-angiogenic but increased anti-angiogenic marker expression at the doses tested. In-vivo efficacy of CEP 1430 was evaluated in female SCID mice bearing human pancreatic CSC. The once daily administration (ip) of CEP1430 (doses:10, 15, and 20 mg/kg) for 30 days resulted in 80%, 89% and 90% tumor growth inhibition. The tumor growth inhibitory effect of CEP1430 in all treatment groups was statistically significant in comparison to vehicle treated control (P&amp;lt;0.001). The administration of CEP1430 for a period of 30 days was well tolerated without significant changes in body weight or toxicity by histological examination of tissues and organs. We are using proteomic and miRNA platforms to monitor biomarkers of response, mode of action and selectivity of CEP1430. Further pre-clinical in-vivo studies are ongoing to project human dose and schedule as monotherapy and in combination with therapeutic vaccination to advance CEP1430 for clinical investigation. Citation Format: Jitesh Jani, Mandana Amiri, Cristian Sharma, Joshua Harris, Shruthi Satish, Michael Sharma, Robert Rodriguez, Miriam Navel, Natalee Amezcua, Shaleekha Sharma, Arun Sharma, Dhimant Desai, Shantu Amin, Satya Narayan, Rubio Punzalan, Jay P. Sharma. A novel pharmacological inhibitor CEP1430 for human pancreatic cancer stem cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4225. doi:10.1158/1538-7445.AM2015-4225
THU0498 The Patients' Experience of Imaging: Views from a Group Convened to Support the Development of Points to Consider for the Use of Imaging in the Diagnosis and Management of Juvenile Idiopathic Arthritis
Authors: A.N. Colebatch-Bourn, C. Malattia, P. Collado, M.A. D'Agostino, R. Hemke, S. Jousse-Joulin, M. Maas, A. Martini, E. Naredo, M. Østergaard, M. Rooney, N. Tzaribachev, M. van Rossum, J. Vojinovic, P.G. Conaghan, C.J. Edwards
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To explore patients9 perspectives on the use of imaging to support development of points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis (JIA) in clinical practice.[1] <h3>Methods</h3> A task force has recently produced points to consider (PTC) for the use of imaging in the diagnosis and management of JIA in clinical practice. Given the challenges of asking children or young adults to attend consensus meetings with the task force members, a separate Patient and Public Involvement (PPI) event was arranged following the second task force meeting where the process and results were presented and all comments were recorded. The PPI event was attended by one child and two young adults with a diagnosis of JIA, two parents of children with JIA, two consultant rheumatologists, one with a special interest in paediatric rheumatology, a paediatric rheumatology nurse specialist and a paediatric research senior nurse. During thorough round table discussion thoughts and ideas related to a child9s experience of imaging for JIA were generated. <h3>Results</h3> There were extensive discussions around differences in the experience of imaging for children with JIA. Although the patients involved were young adults they had personal experience of JIA and also of imaging from early childhood (4 years old in one case). One had experienced conventional X-ray radiology (CR) and the other two had experienced CR, ultrasound (US) and magnetic resonance imaging (MRI). The PPI representatives gave no specific comments on the PTC as they felt they were directed towards medical staff but “thought they all sounded reasonable” and had no objections. However, they did make a number of overarching observations related to imaging in general, and on the individual imaging modalities (table). <h3>Conclusions</h3> This process has provided invaluable insight into understanding the patient perspective on various aspects of imaging in JIA. It highlights the importance of involving patients as far as possible in the development of clinical recommendations. In particular, key concerns related to the environment in which the imaging takes place, the ease of positioning and time taken, the importance of understanding the technology and having rapid access to a result. <h3>References</h3> Colebatch-Bourn AN, et al. EULAR-PRES points to consider for the use of imaging in the diagnosis and management of juvenile idiopathic arthritis in clinical practice. Unpublished data, 2015. <h3>Disclosure of Interest</h3> None declared
AB0577 β2-Microglobulin as a Marker of Disease Activity in Systemic Lupus Erythematosus
Authors: I. Żychowska, D. Suszek, M. Dryglewska, M. Majdan
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Estimating of Systemic Lupus Erythematosus (SLE) activity is necessary for the choice of correct treatment and for monitoring its results. There are many tools for assessment of SLE activity. Clinical methods including the assessment of numerous organs9 involvement and concentration of marker proteins are useful. There are ongoing studies concerning the usefulness of new biochemical markers which correlate with the clinical symptoms and other disease activity indicators. It has been suggested recently in the literature, that such role could be played by β2-microglobulin (β2M) serum concentration. <h3>Objectives</h3> The aim of this study was to investigate the relationship between serum levels of β2M and clinical, immunological markers of disease activity in SLE patients (pts). <h3>Methods</h3> Sixty-nine SLE pts (62 female; 7 men), aged 34.5±11.5 years (range 19-69) with duration of the disease of 5.8±4.8 years (0.5-19) were included. The level of β2M was investigated by enzyme-linked immunosorbent assay. Disease activity was assessed by: SLEDAI-2K, circulating levels of complement C3, C4, anti-double-stranded DNA (anti-DNA) and serum levels of β2M. We also estimated the relationship between serum levels of β2M and clinical manifestations of SLE. <h3>Results</h3> Median serum levels of β2M were 3.0±1.2 μg/ml (1.8-8.6) in SLE pts. Serum levels of β2MG were positive in 24 SLE pts (34.8%). The significant correlations were found between serum levels of β2M and of anti-dsDNA (p=0.04; r=0.26), C3 complement (p=0.02; r= -0.3) and SLEDAI-2K (p=0.0005; r=0.64). The SLE pts with arthritis, vasculitis and hematologic symptoms had significantly higher β2M levels than those without, respectively. <h3>Conclusions</h3> Serum level of β2M can be a good biochemical marker of the activity of SLE, positively correlated with clinical activity of the disease. <h3>References</h3> Kim HA, Jeon JY, Yoon JM, Suh CH. Beta 2-microglobulin can be a disease activity marker in systemic lupus erythematosus. Am J Med Sci. 2010 Apr;339(4):337-340. Hermansen ML, Hummelshøj L, Lundsgaard D, Hornum L, Keller P, Fleckner J, Fox B, Poulsen LK, Jacobsen S. Increased serum β2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus. Lupus.(2012) 21,1098-1104. Wakabayashi K, Inokuma S, Matsubara E, Onishi K, Asashima H, Nakachi S, Hagiwara K. Serum β2-microglobulin level is a useful indicator of disease activity and hemophagocytic syndrome complication in systemic lupus erythematosus and adult-onset Still9s disease. Clin Rheumatol. 2013 Jul;32(7):999-1005. Skare TL, Ferri K, Santos MA. Systemic lupus erythematosus activity and beta two microglobulin levels. Sao Paulo Med J. 2014;132(4):239-42. <h3>Disclosure of Interest</h3> None declared
Progress in the classification of functional psychoses
Authors: W Coryell, M Zimmerman
Journal: American Journal of Psychiatry (1987)

The three most widely used diagnostic systems in American psychiatry--the Feighner criteria, the Research Diagnostic Criteria, and DSM-III--appeared sequentially at 4-year intervals. The fact that the latter two systems each incorporated changes in essentially all diagnostic categories implied progress toward greater validity; however, this assumption has rarely been tested directly. To do this, the authors applied each of these three systems to 98 consecutively admitted patients with nonmanic psychoses. Although family history and 6-month follow-up data strongly supported the validity of diagnostic distinctions made in each of the three systems, they did not show increments in validity with successively developed criteria sets.
Autochthonous Plasmodium vivax malaria in Greece, 2011
Authors: K Danis, A Baka, A Lenglet, W Van Bortel, I Terzaki, M Tseroni, M Detsis, E Papanikolaou, A Balaska, S Gewehr, G Dougas, T Sideroglou, A Economopoulou, N Vakalis, S Tsiodras, S Bonovas, J Kremastinou
Journal: Eurosurveillance (2011)

Between May and September 2011, twenty cases of Plasmodium vivax infection were reported in Greek citizens without reported travel history. The vast majority of those cases were confined to a delimited agricultural area of Evrotas, Lakonia. Conditions favouring locally acquired transmission of malaria, including the presence of competent vectors and migrants from endemic countries exist in Greece, underscoring the need for the development of an integrated preparedness and response plan for malaria prevention.
FRI0425 The Global Antiphospholipid Syndrome Score (GAPSS) Differentiates Between Transient Ischemic Attack and Stroke in Patients with Antiphospholipid Antibodies
Authors: S. Sciascia, G. Sanna, V. Murru, D. Roccatello, M. Khamashta, M.L. Bertolaccini
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Arterial event are frequent in the antiphospholipid syndrome (APS) and stroke is a major clinical manifestation of syndrome. Recently, we conducted a study in a large cohort of Systemic Lupus Erythematosus (SLE) patients applying a risk score for APS clinical manifestations (Global APS Score or GAPSS), demonstrating that risk profile for APS can be successfully assessed. <h3>Objectives</h3> In this study, we aimed to evaluate the clinical usefulness of the GAPSS in differentiating between transient ischemic attack (TIA) and stroke in a cohort of patients tested positive for aPL who sufferedcerebrovascular ev <h3>Methods</h3> We included 40 consecutive SLE patients attending the Louise Coote Lupus Unit at St Thomas Hospital, London, all with a history of cerebravoscular events. Demographic, clinical and laboratory characteristics were collected. aPL profile included anticardiolipin antibodies (aCL), lupus anticoagulant (LA), anti β2 glycoprotein I antibody (anti-β2GPI), and antibodies to phosphatidylserine-prothrombin complex (aPS/PT). Cardiovascular risk factors were assessed following NICE guidelines. The GAPSS system was calculated for each patient <h3>Results</h3> Nineteen patients (47.5%) had stroke, 16 (40%) a transient ischemic attack (TIA), defined as neurologic symptoms or signs lasting less than 24 hours by a neurologist. Five patients (12.5%) experienced both. Thirty patients (75%) fulfilled the current APS classification criteria. Higher values of GAPSS were seen in patients who experienced stroke (alone or in association with TIA) when compared to those with TIA alone (10.13±3.3 [range 5-16] vs. 6.3±4.6 [range 3-13], p=0.033). This observation was confirmed when compared patients who had a history of stroke alone with patients with TIA alone (9.95±3.29 [range 5-16] vs. 6.3±4.6 [range 3-13], p=0.029). Patients who experienced both stroke and TIA showed the highest GAPSS but the difference was only statistically significant when compared to those with TIA alone (10.8±3.63 [range 7-16] vs. 6.3±4.6 [range 3-13], p=0.03). <h3>Conclusions</h3> GAPSS is a valid tool for risk stratification for ischemic manifestation in the setting of cerebrovascular events. This tool may help identifying a more “at risk” population in whom a tailored prophylaxis therapy might be beneficial. <h3>Disclosure of Interest</h3> None declared
Psychiatric test assessment of patients with psychomotor epilepsy
Authors: E A Serafetinides, D G Cherlow
Journal: American Journal of Psychiatry (1976)

The authors evaluated the psychiatric status of 31 patients who had temporal lobectomies and 6 patients who received implantation of depth electrodes for relief of epileptic seizures. Results showed a general postoperative improvement in overall psychopathology (measured by the Brief Psychiatric Rating Scale) and in depression in particular; however, depression tended to recur with the passage of time after lobectomy.
Influences of time, ethnicity, and attachment on depression in Southeast Asian refugees
Authors: M Beiser
Journal: American Journal of Psychiatry (1988)

The author reports on a study investigating the question of whether certain phases of resettlement are accompanied by an elevated risk for depression in Southeast Asian refugees in Canada. In general, the longer the Southeast Asian refugees remained in Canada, the better their mental health. However, unmarried or otherwise unattached Laotians and Vietnamese refugees experienced high levels of depression 10-12 months after arrival. Two years after the initial investigation, this group, disadvantaged by a lack of social resources, continued to be more depressed than other refugees.
P0818 : Analysis of NS3 protease resistance-associated variants and phenotypes for the prediction of treatment response to HCV triple therapy
Authors: J. Dietz, D. Rupp, D. Perner, C. Berkowski, M. Räder, S. Susser, S. Mauss, T. Kuntzen, S. Zeuzem, R. Bartenschlager, C. Sarrazin
Journal: Journal of Hepatology (2015)
Phase I Trial of Plerixafor and Bortezomib As a Chemosensitization Strategy in Relapsed or Relapsed/Refractory Multiple Myeloma
Authors: Irene M. Ghobrial, Ranjit Banwait, Abdel Kareem Azab, Phong Quang, Jacob P. Laubach, Amanda Donovan, Meghan Bagshaw, Philippe Armand, Nikhil C. Munshi, Robert L. Schlossman, Stacey Chuma, Janet Kunsman, Diane Warren, Kenneth C. Anderson, Paul G. Richardson
Journal: Blood (2011)
Step by Step
Authors: Amr H. Sawalha, Michael S. Bronze, Sanjay Saint, Steve Blevins, William Kern
Journal: New England Journal of Medicine (2003)

In this Journal feature, information about a real patient is presented in stages (boldface type) to expert clinicians from several specialties, who respond to the information, sharing their reasoning with the reader (regular type). The authors' commentary follows.A 63-year-old man presented to the emergency department for an evaluation of acute, mild rectal bleeding. He reported a two-week history of exertional dyspnea and generalized weakness, as well as mild pain and fullness in the left upper quadrant of the abdomen, with a weight loss of 13.5 kg (30 lb) over a period of one year. He said that he did not have hematemesis, nausea, vomiting, fever, night sweats, or bone pain.Rectal bleeding in patients in this age group is usually due to diverticulosis, benign anorectal disease, colorectal neoplasia, or angiodysplasia of the bowel, although this . . .
For Rationality in Radiation Risk Studies
Authors: H H Rossi
Journal: JNCI Journal of the National Cancer Institute (1980)

For Rationality in Radiation Risk Studies JNCI: Journal of the National Cancer Institute, Volume 64, Issue 3, March 1980, Page 403, https://doi.org/10.1093/jnci/64.3.403 Published: 01 March 1980
Psychiatric residency, role models, and leadership
Authors: E Sherwood, M Greenblatt, R O Pasnau
Journal: American Journal of Psychiatry (1986)

Two hundred fifty ex-fellowship psychiatrists answered a questionnaire on their administrative and other professional experiences during and after residency as part of a study to determine the relationship between psychiatric training experiences and interest in administration. A large majority of subjects had had role models during training. The subjects' interest in administration had grown significantly during residency in the direction of their role models' interest. Postresidency interest in administration was significantly correlated with supervision by a psychiatrist administrator and with the number of hours subjects spent on administrative work.
Intracranial meningioma with abnormal accumulation of Tc-99m MDP on bone scintigraphy: different intensities between reactive hyperostosis and tumor calcification.
Authors: Seok Tae Lim, Myung-Hee Sohn
Journal: Clinical Nuclear Medicine (2001)

From the Department of Nuclear Medicine* and Institute for Medical Sciences,† Chonbuk National University Medical School, Chonju, Korea Received for publication July 24, 2000. Accepted August 9, 2000. Supported by Korean Research Foundation grant KRF-99-041-F00273. Reprint requests: Myung-Hee Sohn, M.D., Department of Nuclear Medicine, Chonbuk National University Medical School, 634-18 Keumam-dong Duckjin-gu, Chonju, Chonbuk 561-712, Korea. E-mail: [email protected]
Prognostic validity of the dexamethasone suppression test: results of a six-month prospective follow-up
Authors: M Zimmerman, W Coryell, B Pfohl
Journal: American Journal of Psychiatry (1987)

In a 6-month prospective follow-up study, the authors located and interviewed 165 (88.2%) of 187 primary unipolar depressed inpatients to whom a 1-mg dexamethasone suppression test (DST) had been given during their first week of hospitalization. Longitudinal ratings of symptoms over the follow-up period and 6-month cross-sectional ratings on the Hamilton Rating Scale for Depression, the Beck Depression Inventory, and the Global Assessment Scale were obtained for each patient. The authors also collected information on rehospitalization after discharge from the index episode. Baseline DST results were not associated with any of the outcome variables.
T Cells Engineered With a Chimeric Antigen Receptor (CAR) Targeting CD19 (CTL019) Produce Significant In Vivo Proliferation, Complete Responses and Long-Term Persistence Without Gvhd In Children and Adults With Relapsed, Refractory ALL
Authors: Stephan A Grupp, Noelle V. Frey, Richard Aplenc, David M Barrett, Anne Chew, Michael Kalos, Bruce L. Levine, Manuel Litchman, Shannon L Maude, Susan R. Rheingold, Angela Shen, Christine Strait, David T. Teachey, Patricia A. Wood, David Porter, Carl H. June
Journal: Blood (2013)
PWE-235 Long term subcutaneous saline and magnesium administration in patients with a short bowel. 10 year outcomes
Authors: M Small, D Brundrett, JM Nightingale
Journal: Gut (2015)

<h3>Introduction</h3> Subcutaneous administration of water, sodium and magnesium is a treatment for patients with a short bowel and an adequate nutritional status, but with sodium and magnesium depletion. This study aimed to determine the long-term outcomes of patients treated with subcutaneous fluid (SCF). <h3>Method</h3> 10 year retrospective review of medical, dietetic and pharmacy records of patients identified as receiving home SCF administration from an ‘Intestinal Failure’ database. All patients selected had had an inpatient assessment in which bowel function was optimised and a subcutaneous regimen established. All patients were taught to self-administer fluids via gravity through a 22 Gauge plastic cannula inserted prior to each infusion into the subcutaneous tissue of the upper leg or abdomen. Patients were reviewed 3–6 monthly. <h3>Results</h3> 26 patients (19F:7M) were identified). Mean BMI 23.1 ± 4.7 (18.1–41.4). Mean time receiving SCF was 22 ± 34 (0.5–139) months. Underlying condition was Crohn–s/ulcerative colitis (n = 10), surgical complications (n = 8), mesenteric infarction (n = 5), other (n = 3). Mean infusion volume was 4 ± 2.1 (0.5–7) litre/week. 4(15%) patients had &lt;100cm small bowel to stoma, mean duration of SCF was 11 ± 6.9 (3–18) months. 9 (35%) patients had 100–150cm small bowel to stoma, mean duration 16 ± 23 (2–74) months. 11(42%) patients had more than 150cm small bowel to stoma, mean duration 32 ± 47 (0.5–139) months. 2(8%) patients had small bowel to colon, mean duration 19.5 ± 2.1 (18–21) months. There was no difference between patients with &lt;150cm small bowel vs those with &gt;150cm, p = 0.25. 21(81%) patients had magnesium in their infusions, mean 21 ± 9.8 (8–40) mmol per week; 16(76%) having 4mmol and 5(24%) having 8mmol per infusion. Patients on 4mmol magnesium were on treatment 17.4 ± 34 (3–139) months, those on 8mmol 10 ± 8.5 (2–24) months. The difference between these was not significant p = 0.4. Most patients 20(77%) had no complications. 5(19%) patients had leaking at the infusion site after a mean time of 50 ± 56 (8–139) months. Failure of treatment was most commonly due to an infusion taking too long to go in (more than 14 h ± fluid leaking (n = 6). In 2 patients the treatment did not correct magnesium, 2 patients had weight loss requiring parenteral nutrition. 6 patients stopped after corrective surgery. 2 patients were transferred elsewhere. 8 patients are still on treatment. <h3>Conclusion</h3> SCF are well tolerated in patients with a short bowel and sodium and magnesium depletion. Most patients continue with no complications for more than a year. Stopping SCF did not relate to small bowel length or the presence of magnesium but most commonly to the failure of the subcutaneous tissues to accept the infusion fluid. <h3>Disclosure of interest</h3> None Declared.
The Effect of Mild Left Ventricular Diastolic Dysfunction on Outcome After Isolated Coronary Bypass Surgery
Authors: Aleks Değirmencioğlu, Şahin Şenay, Ümit Güllü, Gültekin Karakuş, Ertuğrul Zencirci, Ali Buturak, Murat Uğur, Gökmen Gemici, Ahmet Akyol, Seden Erten Çelik, Cem Alhan
Journal: Journal of the American College of Cardiology (2013)
GP who was struck off for lying to police is allowed back on medical register
Authors: Clare Dyer
Journal: BMJ (2016)

A South Yorkshire GP who was struck off in November 2009 for lying to police and to a coroner’s inquest has been allowed back on the medical register after a fitness to practise tribunal found that he had made exceptional efforts at remediation.1

Nigel Palmer, 52, lied to cover up his failure to take action in the case of Eileen Gill, an 82 year old smoker known to be careless with matches, before she died in a fire at her home in September 2007.

Her daughter had called Barnsley social services from her home in Spain that summer to express concern about the risk. Social services …