tbuckley/cabot-search huggingface dataset:
Levamisole and melanoma.
Authors: M R Kurman
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.9.1714 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 1875227 Levamisole and melanoma. M R KurmanxM R KurmanSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.9.1714 PDF "Levamisole and melanoma.." Journal of Clinical Oncology, 9(9), pp. 1714–1715© 1991 by American Society of Clinical Oncology
Delayed antibiotics reduced antibiotic use in acute respiratory infection without increasing symptom duration
Authors: Paul Glasziou
Journal: Annals of Internal Medicine (2016)

Source Citation de la Poza Abad M, Mas Dalmau G, Moreno Bakedano M, et al; Delayed Antibiotic Prescription (DAP) Group. Prescription strategies in acute uncomplicated respiratory infections: a randomized clinical trial. JAMA Intern Med. 2016;176:21-9. 26719947
Birth order of patients with DSM-III-R somatization disorder
Authors: F W Brown, G R Smith
Journal: American Journal of Psychiatry (1989)

A sample of 143 patients, 76 meeting strict DSM-III-R criteria for somatization disorder and 67 somatizers, was studied using Slater's index to measure birth order position. The results showed that birth order position was not associated with the diagnosis of somatization disorder and that sibship position in both groups occurred by chance. Thus, although environmental factors may influence the development of somatization disorder, the expression of environmental influence through birth order is unlikely.
A Retrospective Analysis of Safety and Efficacy of Ruxolitinib in CALR-Positive Patients with Myelofibrosis
Authors: Paola Guglielmelli, Giada Rotunno, Costanza Bogani, Carmela Mannarelli, Matthew Squires, Viktoriya Stalbovskaya, Prashanth Gopalakrishna, Alessandro M. Vannucchi
Journal: Blood (2014)
Urinary metabolomic profiling of asthmatics can be related to clinical characteristics
Authors: C. C. Loureiro, A. S. Oliveira, M. Santos, A. Rudnitskaya, A. Todo‐Bom, J. Bousquet, S. M. Rocha
Journal: Allergy (2016)

Metabolomics has been increasingly explored to achieve an improved understanding of asthma. In the current observational and exploratory study, the first to have examined the relationship between oxidative stress extension, eosinophilic inflammation, and disease severity in asthmatic patients, metabolomics (using target aliphatic aldehydes and alkanes) was carried out using solid-phase microextraction (SPME) followed by a comprehensive two-dimensional gas chromatography coupled to mass spectrometry with a high-resolution time-of-flight analyzer (GC×GC-ToFMS). We were able to demonstrate that metabolomics can give valuable insights into asthma mechanisms once lipidic peroxidation assessed by urinary metabolomics is related to the clinical characteristics of nonobese asthmatics, such as disease severity, lung function, and eosinophilic inflammation. Nevertheless, considering our sample size, the obtained results require further validation using a much larger sample cohort.
Oncologist pays $300 000 to settle US claims of billing for fake cancer drug
Authors: Owen Dyer
Journal: BMJ (2016)

A California oncologist and his wife, who was also his office manager, have paid $300 000 (£205 000; €268 000) to settle government allegations that they billed Medicare for illegally imported, unapproved cancer drugs—which later turned out to contain no active ingredient.

John F Kiraly III became the third oncologist in California, and at least the fifth nationwide, to be ensnared in a federal investigation into illegal shipments from a Turkish pharmaceutical distributor. Many of the shipments were ordered through a British wholesaler, Warwick Healthcare Solutions, also known as Richards Pharma.

The case dates from 2011, when the Food and Drug Administration’s (FDA) office of criminal investigation found misbranded and unapproved cancer drugs …
The Effect of a Community Mental Health Center Upon State Hospital Utilization
Authors: George Dyck
Journal: American Journal of Psychiatry (1974)

A private psychiatric hospital that developed comprehensive community mental health services was able to reduce admissions to state hospitals from its catchment area to two-thirds less than the state average over a 12-year period. This was accomplished without the use of state funding for inpatient care. The author describes the various programs developed in collaboration with community representatives and other agencies, which have significantly reduced the need for state hospital care.
Science and the Predicament of Man
Authors: J.R. E.
Journal: Annals of Internal Medicine (1970)

Editorials1 March 1970Science and the Predicament of ManJ.R. E.J.R. E.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-3-432 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptPopulation,pollution, poverty, proliferationandpriorities, politics, procrastination—these are the names for some of the lion-sized problems that beset man as he enters the 1970's. Daily we are warned of the precariousness of the human situation. The crisis of overpopulation is upon us with its attendant problems of poverty, hunger, urbanization, and racial tension. Pollution from our technologic society is destroying progressively our total planetary environment. The steady proliferation of nuclear, chemical, and biological arms already has gone far beyond the level of potential species overkill. Our political processes for domestic and international self-government are inadequate, and mankind procrastinates in...References1. Science and the Future of Man. Proceedings of this symposium to be published by the Massachusetts Institute of Technology Press, Cambridge Google Scholar2. The Identity and Dignity of Man. Proceedings of this conference to be published by the Schenkman Publishing Co., Cambridge, 1970 Google Scholar3. HARDIN G: The tragedy of the commons. Science 162:1243-1248, 1968 CrossrefMedlineGoogle Scholar4. CROWE B: The tragedy of the commons revisited. Science 166:1103-1107, 1969 CrossrefMedlineGoogle Scholar5. PLATT J: What we must do. Science 166:1115-1121, 1969 CrossrefMedlineGoogle Scholar6. MEDAWAR P: Quoted by Greenberg DS, in Science 165:1239-1240, 1969 CrossrefMedlineGoogle Scholar7. DUBOS R: A Social design for science (editorial). Science 166:823, 1969 CrossrefMedlineGoogle Scholar8. New York Times, January 4, 1970 Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byIn Memoriam: J. Russell Elkinton, MD, MACP, FRCP(L); 1910–2002; Editor, Annals of Internal Medicine, 1960–1971Edward J. Huth, MD, Editor EmeritusOutlook for Treating Patients with Self-Destructive HabitsJOHN F. BURNUM, M.D., F.A.C.P. 1 March 1970Volume 72, Issue 3Page: 432-434KeywordsPollutionPopulation density ePublished: 1 December 2008 Issue Published: 1 March 1970 PDF downloadLoading ...
Research to Publication:<i>The BMJ</i>launches a new e-learning programme in healthcare research—a valuable resource for sports medicine (continuing professional development series)
Authors: Adam G Culvenor
Journal: British Journal of Sports Medicine (2016)

The BMJ , in collaboration with the University of California San Francisco (UCSF).

Research to Publication e-learning programme.

‘Congratulations, we are pleased to accept your manuscript for publication’—the e-mail notification that every researcher dreams of waking up to. Whether screening large numbers of athletes to identify risk factors for injury or diligently recording return to play outcomes, sports medicine researchers aim to publish, disseminate and implement to enhance outcomes for athletes1 and patients alike. However, as in other areas of health research, there is a problem with sports medicine research—up to 85% of it is going to waste.2 Researchers are not necessarily developing relevant research questions, studies are not always performed with the best methods, many important studies are not published and a lot of research that is published is not reported well.2 Key scientific and ethical requirements for successful publication are a mystery …
PTU-114 Prevalence rates of acute hepatitis a (HAV) and hepatitis e (HEV) in surrey, south east england: how many hev cases are being missed?
Authors: S Mathew, M Pericleous, M Atkins, M Nicholls, A Ala
Journal: Gut (2015)

<h3>Introduction</h3> Rates of infection from Hepatitis E virus (HEV) have risen dramatically since 2010, whilst cases of acute Hepatitis A (HAV) have dropped over the same period, with 691 diagnosed HEV cases in 2013 in England and Wales, compared to 283 cases of HAV. However, despite the rising prevalence of HEV it is widely presumed that HAV testing remains the predominant diagnostic investigations for acute (enteric) hepatitis. <h3>Method</h3> We collected data on HAV (IgM) testing in all patients from January 2012 to 2015 across the Surrey Pathology Partnership, serving a population of 1.1 million. We contrasted HEV (IgM, IgG) testing in this patient group over the same time period in hospital and community settings. <h3>Results</h3> Acute HAV (IgM) testing was ordered in 881 patients; 246 in a community setting and 635 in hospital/GUM practice. The testing indication was poorly documented in most cases, with “raised LFTs”, “Jaundice” and “Hepatitis” as the predominant indicators. HEV testing was requested in 380 patients overall; 31 (12%) in community practice and 349 (92%) in hospital/GUM settings. The majority (79%) of HEV requests were made over the past year (Jan 2014–2015). Acute HAV infection was identified in 30/881 patients, and acute HEV infection in 42 patients with a prevalence of 3.4% and 11% respectively. Evidence of HEV exposure was identified in a further 26 patients (7%), with an overall prevalence rate of 18% for past or present HEV infection. The median age of patients with acute HEV was 56 years, with the majority being male (57%). <h3>Conclusion</h3> Despite the higher number of requests for laboratory testing of HAV over HEV, this study highlights the observation that HEV is in fact more prevalent. Poor uptake of HEV testing, particularly in the community, could be improved by enhanced educational support. 501 patients were not tested for HEV in this study. The additional cost of testing this group would be £5821 (£11.62/test) and this could be justified if one considers the threefold increase in prevalence of HEV compared to HAV infection. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Public Health England, Hepatitis E, symptoms, transmission, treatment and prevention, June 2014 [https://www.gov.uk/government/publications/hepatitis-e-symptoms-transmission-prevention-treatment/hepatitis-e-symptoms-transmission-treatment-and-prevention]
Review of C. Bruce, M. Majumder, T. Bibler, L. McCullough, J. Blumenthal-Barby, N. Allen, A. Peña, and A. McGuire,Developing and Sustaining a Clinical Ethics Consultation Service: A Practical Guide1
Authors: Denise M. Dudzinski
Journal: The American Journal of Bioethics (2016)

"Review of C. Bruce, M. Majumder, T. Bibler, L. McCullough, J. Blumenthal-Barby, N. Allen, A. Peña, and A. McGuire, Developing and Sustaining a Clinical Ethics Consultation Service: A Practical Guide1." The American Journal of Bioethics, 16(6), pp. W4–W5
Induction of Intracisternal Type A Particles by 5-Bromo-2′-deoxyuridine in Rat Hepatoma Cells: Brief Communication2
Authors: Heather W. Weber, Ann Geddes, Robert H. Stellwagen
Journal: JNCI Journal of the National Cancer Institute (1978)

Electron microscopic examination of hepatoma tissue culture (HTC) cells revealed low numbers of intracisternal type A particles (lAP) and type C viruses. Exposure of HTC cells to either 10−4 or 10−5M 5-bromo-2′-deoxyuridine (BUdR) caused a more than 50-fold increase in the number of IAP observed with the electron microscope. The number of IAP increased after only 2 days of growth in 10−5M BUdR, whereas 3 days of growth in 10−4 M BUdR were necessary to observe an increase. A 2-day pulse of 10−4M BUdR was also sufficient to cause the increase in type A particles, provided the cells were continued in culture for another 2 days. Unlike many other cell lines, HTC cells treated with BUdR did not show an increase in type C viruses. This conclusion was based on the observations that BUdR treatment caused no detectable increase in extracellular particulate viral reverse transcriptase or in viral RNA complementary to a DNA probe made to a rat endogenous type C virus (RaLV).
Case 25-1964
Authors: Arnold N. Weinberg, Robert E. Scully
Journal: New England Journal of Medicine (1964)

Presentation of CaseA sixty-eight-year-old man entered the hospital because of muscle weakness.He had been well until four weeks previously, when a sore throat developed, accompanied by coryza, cough and malaise. A physician prescribed a sulfonamide, and his symptoms improved promptly. Several days later he began to experience pain in the muscles of the thighs and calves that interfered with walking. Ten days before entry he was admitted to another hospital because of the appearance of mild ankle edema. Physical examination revealed a faint apical systolic murmur, tenderness of the thigh and calf muscles, brownish pigmentation of the skin . . .
Smoking and Atherosclerosis
Authors: M Kunze, B Schwarz
Journal: BMJ (1966)

Smoking is one of the three major cardiovascular risk factors, the other two being hyperlipidaemia and hypertension. Cardiovascular diseases contribute in Austria, as well as in other industrialized countries, more than 50% to total mortality. Unlike in other industrialized countries ischaemic heart diseases in Austria have an unfavourable mortality trend, with a substantial relative increase. The atherogenicity of smoking is partly caused by interaction with other risk factors, especially hyperlipidaemia, hypertension and a high fibrinogen level. 30% of the Austrian population are smokers. The percentage has increased over the past few years, especially in young women. Other cardiovascular risk factors are very common too and, hence, a large proportion of the Austrian population is at risk due to a combination of risk factors. Smoking and the use of oral contraceptives is associated with significant risk of both myocardial infarction and stroke. The Austrian trend of cigarette smoking among young women points to a substantial increase in the number of women at risk by this combination of risk factors. Strategies to control the smoking epidemic have been internationally tested. An integrated approach is set out in a document provided by the International Union Against Cancer (1983). In a country like Austria with a tobacco monopoly the conditions for implementing smoking control measures should theoretically be better than in other countries.
Soundings: Medical intuition
Authors: Kevin Barraclough
Journal: BMJ (2006)

Specificity is the unsung hero in general practice. When I was a medical student it was the poor relative to sensitivity. Sensitivity was all about making smart diagnoses. But as you get older you realise the importance of identifying those who should remain confident in their health—the importance of not seeing disease everywhere, of not medicalising the world.

When trying to explain the fundamental laws of nature the physicist Richard Feynman used the analogy of watching the gods playing chess. If we do not know the rules then we struggle to see what is going on. The gods play fast and loose, and we cannot discern the pattern in the complexities of the game. But then we notice a conserved rule. The bishop always stays on the same colour square. We may look away, our attention may be deflected by the rich diversity of the world, but when we look back at the game this feature is unchanged. We have seen a pattern—a conserved property.

Sometimes I feel as though, under the surface of medicine, there are some great rules that I am missing. Buried in the complexity of symptoms, biological age, organic disease, unhappiness, and anxiety, there are deep conserved principles that are not quite discernible. The principles may be “intuition” or a “clinical nose.” They guide our actions in a way that we would never be able to defend in a court of law. But the whole process is unsatisfactory because while it is powerful and real—it (usually) helps the experienced to make fewer mistakes than the inexperienced—it is poorly defined.

Yet no laboratory test ever comes close to intuition in this level of specificity and sensitivity. Almost everybody coming through the door could have significant disease on the basis of their symptoms but it is potentially immensely harmful if they are all investigated.

General practitioners should be utilitarians and should be encouraged to be so. It is possible never to miss a diagnosis but in the process to create huge anxiety in legions of people by over-investigating them. The old adage may be true—that if you never make mistakes then maybe you are not seeing enough patients. The arithmetical benefit of causing huge anxiety to the legions of worried well with low risk of significant disease but picking up the one phaeochromocytoma does not add up. Jeremy Bentham would turn in his grave.
Response to “Variable directionality of gene expression changes across generations does not constitute negative evidence of epigenetic inheritance” Sharma, A. Environmental Epigenetics, 2015, 1-5
Authors: Piroska E. Szabó
Journal: Genome biology (2016)

Abhay Sharma brings two arguments in favor of transgenerational epigenetic inheritance (TGEI) in mammals when criticizing our work. He uses probability calculations and finds that the probability of obtaining the number of common changes in the in utero-exposed prospermatogonia and the same cells in the next generation is significant in our study. He also compares our results to other published datasets and concludes that the probability for the observed overlap between independent studies is significant. We disagree with both arguments of Sharma and show here that his meta-analysis and statistical calculations are not correct.
Rabies in an Arctic fox on the Svalbard archipelago, Norway, January 2011
Authors: I Ørpetveit, B Ytrehus, T Vikøren, K Handeland, A Mjøs, S Nissen, H Blystad, A Lund
Journal: Eurosurveillance (2011)

Binary file ES_Abstracts_Final_ECDC.txt matches
Serum Cholesterol and Human Colon Cancer&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Seth R. Miller, M.Sc., Paul I. Tartter, M.D., Angelos E. Papatestas, M.D.
 5, Gary Slater, M.D., Arthur H. Aufses, Jr., M.D.
Journal: JNCI Journal of the National Cancer Institute (1981)

Comparison of serum cholesterol levels in a matched case-control study indicates that patients with colon cancer have serum cholesterol levels lower than those of controls. In 133 pairs matched by age and sex, serum cholesterol levels were 188 +/- 42 mg/dl for cases and 213 +/- 42 mg/dl for controls (paired t-test = 5.08; P less than 0.001). Following stratification by tumor stage, significant differences in serum cholesterol levels persisted between cases with advanced tumors (Duke's classification C1, C2, and D) and controls (mean serum cholesterol difference, 41 +/- 41 mg/dl; paired t-test = 6.16; P less than 0.001) but not between cases with early tumors (Duke's classification A, B1, and B2) and controls, although the same trend was noted. Matching of 130 early tumors to advanced tumors showed that women, but not men, had a significantly lower serum cholesterol level with advancing disease. The findings support the concept that low serum cholesterol levels observed in colon cancer patients may be the result of the metabolic influence of advanced tumors, at least in women, and may not necessarily precede tumor formation.
Induction of Skin Tumors in Strain DBA Mice Following Intermittent Treatment With 9,10-Dimethyl-1,2-Benzanthracene and Croton Oil&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Michael Klein
Journal: JNCI Journal of the National Cancer Institute (1955)

Induction of Skin Tumors in Strain DBA Mice Following Intermittent Treatment With 9,10-Dimethyl-1,2-Benzanthracene and Croton Oil Get access Michael Klein Michael Klein Cancer Research Laboratory, University of Florida, Gainesville, Fla. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 6, June 1955, Pages 1685–1689, https://doi.org/10.1093/jnci/15.6.1685 Published: 01 June 1955 Article history Received: 20 December 1954 Published: 01 June 1955
Use of Cooking Fuels and Cataract in a Population-Based Study: The India Eye Disease Study
Authors: Thulasiraj D. Ravilla, Sanjeev Gupta, Ravilla D. Ravindran, Praveen Vashist, Tiruvengada Krishnan, Giovanni Maraini, Usha Chakravarthy, Astrid E. Fletcher
Journal: Environmental Health Perspectives (2016)

Biomass cooking fuels are commonly used in Indian households, especially by the poorest socioeconomic groups. Cataract is highly prevalent in India and the major cause of vision loss. The evidence on biomass fuels and cataract is limited.
Inhibition of fatty acid oxidation modulates immunosuppressive functions of myeloid-derived suppressor cells and enhances cancer therapies
Authors: Amir A Al-Khami, Fokhrul Hossain, Dorota Wyczechowska, Claudia Hernandez, Liqin Zheng, Krzystoff Reiss, Luis Del Valle, Jimena Trillo-Tinoco, Tomasz Maj, Weiping Zou, Paulo C Rodriguez, Augusto C Ochoa
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Myeloid-derived suppressor cells (MDSC) promote tumor growth by inhibiting T cell immunity and supporting malignant cell proliferation and migration. The therapeutic potential of blocking MDSC in tumors has been limited by their heterogeneity, plasticity, and resistance to various