tbuckley/cabot-search huggingface dataset:
Lack of Carcinogenicity of Lyophilized &lt;italic&gt;Schistosoma&lt;/italic&gt; in Mice
Authors: M B SHIMKIN, P O MUSTACCHI, E B CRAM, W H WRIGHT
Journal: JNCI Journal of the National Cancer Institute (1955)

Lack of Carcinogenicity of Lyophilized Schistosoma in Mice Get access Michael B. Shimkin, Michael B. Shimkin National Cancer Institute and National Microbiological Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Piero O. Mustacchi, Piero O. Mustacchi National Cancer Institute and National Microbiological Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Eloise B. Cram, Eloise B. Cram National Cancer Institute and National Microbiological Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Willard H. Wright Willard H. Wright National Cancer Institute and National Microbiological Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 2, October 1955, Pages 471–474, https://doi.org/10.1093/jnci/16.2.471 Published: 01 October 1955 Article history Received: 11 May 1955 Published: 01 October 1955
Tolerability of 6-Mercaptopurine (6MP) in Patients with Thiopurine Methyltransferase (TPMT) Heterozygosity in the Context of Multi-Agent Therapy for Acute Lymphoblastic Leukemia (ALL)
Authors: Chengcheng Liu, Deqing Pei, Cheng Cheng, Jun J. Yang, Kristine Crews, Wenjian Yang, Seth E. Karol, Sima Jeha, John T. Sandlund, Raul C Ribeiro, Jeffrey E Rubnitz, Monika L. Metzger, Ching-Hon Pui, William E. Evans, Mary V. Relling
Journal: Blood (2014)
Open-label, randomized multicenter phase II clinical trial of a toll-like receptor-2 (TLR2) agonist mycobacterium w (Cadi-05) in combination with paclitaxel plus cisplatin versus paclitaxel plus cisplatin in advanced non-small cell lung cancer (NSCLC).
Authors: C. P. Belani, D. Desai, B. M. Khamar
Journal: Journal of Clinical Oncology (2011)

7501 Background: TLR2 agonist, mycobacterium w (Cadi-05), a non-specific immunomodulator and pure Th 1 response enhancer has demonstrated synergistic effects with a number of chemotherapeutic agents. A phase II randomized study was conducted to test the efficacy of the combination of paclitaxel plus cisplatin with or without Cadi-05 as first line treatment of advanced NSCLC. Methods: Two hundred and twenty-one treatment naïve patients (pts) with stage IIIB and IV NSCLC were randomized to receive paclitaxel 175mg/m2 IV 3-hour infusion and cisplatin 100mg/m2 IV with or without Cadi-05 administered intradermally, 0.1 ml on each deltoid on the first visit at least 1 week prior to 1st cycle and then on day 8 and 15 of each cycle of chemotherapy. The cycles were repeated every 3 weeks for a total of 4 cycles. Cadi-05 was administered once a month thereafter until progression or for a maximum of 12 months from the start of treatment in the investigational arm. The primary endpoint of the study was overall survival (OS) and the secondary outcome measures were response rate (RR) and progression free survival (PFS). Results: One hundred twelve pts were randomized to the control arm and 109 pts to the Cadi-05 arm. Pt demographics were balanced in both the arms. The RR was 36% in the control arm and 47 Cadi-05 arm. There were three complete responses all in the Cadi-05 arm. Median PFS was 157 days in control arm and was improved by 96 days to 253 days in the Cadi-05 arm [p=0.0446; HR 0.43 (95% CI 0.25-0.73)]. Median OS was 236 days in control arm and was improved by 59 days to 295 days in the Cadi-05 arm [p=0.0034;HR 0.55(95% CI 0.37-0.82)]. There were no significant differences in the adverse events in the control arm vs. the Cadi-05 arm. Conclusions: Addition of Cadi-05 to paclitaxel plus cisplatin in patients with advanced NSCLC is safe and results in both improvement in PFS and OS. The study is supported by Cadila Pharmaceuticals Ltd and is being presented on behalf of the Cadi-05 investigators study group.
Brain Tumors in Children Exposed to Barbiturates
Authors: Johannes Clemmesen, S. Hjalgrim-Jensen
Journal: JNCI Journal of the National Cancer Institute (1981)

Journal Article Brain Tumors in Children Exposed to Barbiturates Get access Johannes Clemmesen, Johannes Clemmesen Cancerregisteret, Strandboulevard 49, Copenhagen, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Hjalgrim-Jensen S. Hjalgrim-Jensen Cancerregisteret, Strandboulevard 49, Copenhagen, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 66, Issue 2, February 1981, Page 215, https://doi.org/10.1093/jnci/66.2.215 Published: 01 February 1981
Hyposthenuria as a marker for self-induced water intoxication and schizophrenic disorders
Authors: V Vieweg, W Rowe, J David, W Spradlin
Journal: American Journal of Psychiatry (1984)

Four patients with the syndrome of self-induced water intoxication and schizophrenic disorders, as well as inappropriate antidiuresis, are described. In each case, severe hyposthenuria preceded the clinical symptoms by 1 to 7 years. Hyposthenuria may be a marker for this syndrome.
Behavioral Risk Factor Surveillance — Selected States, 1987
Authors: G C Hogelin
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HG-127ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMAS: A CLINICOPATHOLOGIC AND MOLECULAR PROFILE
Authors: Devorah Segal, Cheddhi Thomas, Christopher Bowman, Kasthuri Kannan, Shiyang Wang, Adriana Heguy, Benjamin Liechty, David Jones, Volker Hovestadt, Stefan Pfister, Matthias Karajannis, Matija Snuderl
Journal: Neuro-Oncology (2016)
HG-45PSEUDOPROGRESSION AFTER RADIO-CHEMOTHERAPY IN CHILDREN WITH DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG):IMPACT ON SURVIVAL IN PATIENTS TREATED WITH ERLOTINIB OR TEMOZOLOMIDE
Authors: Marion Gilbert-Yvert, Frederic Dhermain, Stephanie Bolle, Sandra Canale, Christelle Dufour, Jacques Grill
Journal: Neuro-Oncology (2016)
HG-50COMPARATIVE ANALYSES OF PEDIATRIC VERSUS ADULT GLIOBLASTOMA GENOMES &amp; IDENTIFICATION OF UPSTREAM REGULATORS
Authors: Wan-Yee Teo, Seshachalam Veerabrahma Pratap, Sekar Karthik, Xiaonan Li, Jack M. Su, Jianhe Shen, Thomas Chow, Ching C. Lau, Kam-and Man Hui
Journal: Neuro-Oncology (2016)
MB-79CENTRALISED MOLECULAR PATHOLOGY FOR RARE TUMOURS: A NATIONAL FEASIBILITY STUDY OF REAL-TIME MEDULLOBLASTOMA DIAGNOSTICS
Authors: Stephen Crosier, Debbie Hicks, Edward Schwalbe, Daniel Williamson, Sarah Nicholson, Antony Michalski, Barry Pizer, Simon Bailey, Nick Bown, Keith Robson, Stephen Wharton, Thomas Jacques, Steven Clifford
Journal: Neuro-Oncology (2016)
CR-06HYDROCEPHALUS AND HYPOTHALAMIC INVOLVEMENT IN PEDIATRIC PATIENTS WITH CRANIOPHARYNGIOMA OR CYSTS OF RATHKE'S POUCH: IMPACT ON LONG-TERM PROGNOSIS
Authors: Anna M. Daubenbüchel, Anika Hoffmann, Ursel Gebhardt, Monika Warmuth-Metz, Anthe S. Sterkenburg, Hermann L. Müller
Journal: Neuro-Oncology (2016)

OBJECTIVE: Pediatric patients with sellar masses such as craniopharyngioma (CP) or cyst of Rathke's pouch (CRP) frequently suffer disease-and treatment-related sequelae.We analyzed the prognostic relevance of initial hydrocephalus (HY) and hypothalamic involvement (HI) on long-term survival and functional capacity (FC) in children with CP or CRP.SUBJECTS AND METHODS: Using retrospective analysis of patient records, presence of initial HY or HI was assessed in 177 pediatric patients (163 CP, 14 CRP).Twenty-year overall survival (OS) and progression-free survival (PFS), functional capacity, and body mass index (BMI) were analyzed with regard to initial HY, degree of resection, or HI.RESULTS: 105 patients (103/163 CP, 2/14 CRP) presented with initial HY and 96 presented with HI.HY at diagnosis was associated (p ¼ 0.000) with papilledema, neurological deficits, and higher BMI at diagnosis and during follow-up.OS, PFS, and FC were not affected by HY at initial diagnosis.HI at diagnosis (96/177) had major negative impact on long-term prognosis.Sellar masses with HI were associated with lower OS (0.84 + 0.04;p ¼ 0.021), lower FC (p ¼ 0.003), and higher BMI at diagnosis and last follow-up (p ¼ 0.000) when compared with sellar masses without HI (OS: 0.94 + 0.05).PFS was not affected by HI or degree of resection.CONCLUSIONS: Initial HY has no impact on outcome in patients with sellar masses.OS and FC are impaired in survivors presenting with initial HI.PFS is not affected by HY, HI, or degree of resection.Accordingly, gross-total resection is not recommended in sellar masses with initial HI to prevent further hypothalamic damage.
CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism
Authors: Juliana Camacho-Pereira, Mariana G. Tarragó, Claudia C.S. Chini, Veronica Nin, Carlos Escande, Gina M. Warner, Amrutesh S. Puranik, Renee A. Schoon, Joel M. Reid, Antonio Galina, Eduardo N. Chini
Journal: Cell Metabolism (2016)
Bone Scintigraphic Findings in MRSA Osteomyelitis
Authors: Patricia Cornejo, Gerald A. Mandell
Journal: Clinical Nuclear Medicine (2015)

Methicillin-resistant Staphylococcus aureus osteomyelitis is a severe form of infection characterized by multifocal or multiple segmental osseous involvement and subperiosteal abscess formation with increased frequency of extraosseous complications including pyomyositis, septic thrombus, and septic arthritis. Bone scan showed long segment and/or multifocal involvement in 4 of 5 patients with areas of abnormal increased and decreased uptake. The clinical presentations included limp and/or pain. Joint involvement was seen in 4 cases. Bone scan abnormalities correlated well with MRI findings of severe and extensive bone disease, abscess formation, muscle, as well as joint and soft tissue involvement.
Partial Codes—When “Less” May Not Be “More”
Authors: Paul Rousseau
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
GC-17THE CHILDREN'S ONCOLOGY GROUP (COG) CURRENT TREATMENT APPROACH FOR CHILDREN WITH NEWLY DIAGNOSED CENTRAL NERVOUS SYSTEM (CNS) LOCALIZED GERMINOMA (ACNS1123 STRATUM 2)
Authors: Soumen Khatua, Jason Fangusaro, Girish Dhall, James Boyett, Shengjie Wu, Ute Bartels
Journal: Neuro-Oncology (2016)

pre-irradiation chemotherapy may allow for a safe
Avoiding Opioid Analgesics for Treatment of Chronic Low Back Pain
Authors: Jane C. Ballantyne
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genomic approaches to the burden of kidney disease in Sub-Saharan Africa: the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network
Authors: Charlotte Osafo, Yemi R. Raji, Timothy Olanrewaju, Manmak Mamven, Fatiu Arogundade, Samuel Ajayi, Ifeoma Ulasi, Babatunde Salako, Jacob Plange-Rhule, Yewondwossen Mengistu, S.O. Mc'Ligeyo, George Moturi, Cheryl A. Winkler, Marva M. Moxey-Mims, Rebekah S. Rasooly, Paul Kimmel, Dwomoa Adu, Akinlolu Ojo, Rulan S. Parekh
Journal: Kidney International (2016)
Travel associated legionellosis among European tourists in Spain
Authors: A Galmés Truyols, J. F. Martinez Navarro
Journal: Eurosurveillance (1997)

Depuis la deuxieme moitie des annees 1980, la legionellose associee au voyage est devenue preoccupante pour les pays europeens en raison de la morbidite dans la population europeenne; de plus, l'apparition de cas chez les touristes constitue une menace p
Effects of Epinephrine on Free Fatty Acid Mobilization in Hyperthyroid and Hypothyroid Subjects
Authors: J HAMBURGER, R W SMITH, J M MILLER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
QOS-45SPECIFIC INTERVENTION CARE IN CHILDREN TREATED FOR BRAIN TUMOURS: A SOCIAL-SKILLS TRAINING GROUP INTERVENTION IN GUSTAVE ROUSSY CANCER CAMPUS
Authors: Camille Pouchepadass, Clémentine Lopez, Audrey Longaud-Valès, Anne-Laure Domert, Christelle Dufour, Dominique Valteau-Couanet, Sarah Dauchy
Journal: Neuro-Oncology (2016)
MPC-6827, a small molecule inhibitor of microtubule formation with high brain penetration: absorption, distribution, metabolism, excretion, and clinical considerations
Authors: Kevin Jessing, Kimberly Mauck, Chad Bradford, J. Scott Patton, Leslie Reeves, Katrina Bulka, Hong Zhang, Nilantha Sirosoma, Sui Xiong Cai, Gary Mather
Journal: Cancer Research (2005)

Proc Amer Assoc Cancer Res, Volume 46, 2005

3413 

MPC-6827 is a lead drug candidate that displays proapoptotic activity, with potency at low nanomolar concentrations in multiple cancer types including pancreatic, prostate, breast, colorectal, non-small cell lung, small cell lung, melanoma, ovarian and leukemia (Abstracts 5361 and LB252, 95th Annual Meeting of the AACR, 2004). The ADME (Absorption, Distribution, Metabolism and Excretion) properties of MPC-6827 were studied to facilitate the design and implementation of clinical studies. MPC-6827 was incubated in vitro in suspensions of rat and human liver microsomes and S9 fractions. Samples were analyzed by mass spectrometry to identify primary and secondary metabolites and to predict metabolic fate. Urine from rats treated with MPC-6827 was examined by mass spectrometry for confirmation. Rat and human plasma fortified with MPC-6827 was dialyzed to equilibrium to estimate plasma protein binding. In vitro activity of MPC-6827 against cell lines over-expressing the multi-drug resistance pumps MDR-1, MRP-1 or BCRP was evaluated to estimate the potential for efflux. In vivo experiments in mice provided pharmacokinetic information on the tissue distribution of MPC-6827. MPC-6827 is highly protein bound 98.3% in rat plasma and 98.2% in human plasma. The primary metabolic products of MPC-6827 are the demethyl metabolite and its glucuronide and sulfate conjugates, all found predominantly in urine. MPC-6827 distributes rapidly and extensively into the CNS, exhibiting 14-fold higher brain exposure relative to plasma and elimination half-life similar to plasma. In addition, MPC-6827 is not a substrate for the main multi-drug resistance pumps. These ADME properties suggest that MPC-6827 may be well suited for treatment of primary or metastatic tumors arising within the CNS; tumors that have progressed despite best standard treatment; or tumors that are no longer sensitive due to multi-drug efflux pumps. These targets are the subject of Phase 1 clinical studies.
Leaving EU would worsen NHS finances, warns former Tory health secretary
Authors: Gareth Iacobucci
Journal: BMJ (2016)

The United Kingdom’s exit from the European Union would threaten NHS funding, the chairman of the NHS Confederation and former Conservative health secretary, Stephen Dorrell, has warned.

In his opening speech to delegates at the confederation’s annual conference in Manchester this week, Dorrell warned that the economic consequences of so called “Brexit” could destabilise public finances and make it harder to provide sustainable …
MB-103DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS
Authors: Allison Hanaford, Tenley Archer, Antoinette Price, Ulf Kahlert, Jarek Maciaczyk, Guido Nikkhah, Jong Wook Kim, Tobias Ehrenberger, Paul A. Clemons, Vlado Dančík, Brinton Seashore-Ludlow, Vasanthi Viswanathan, Michelle L. Stewart, Matthew G. Rees, Alykhan Shamji, Stuart Schreiber, Ernest Fraenkel, Scott L. Pomeroy, Jill P. Mesirov, Pablo Tamayo, Charles Eberhart, Eric Raabe
Journal: Neuro-Oncology (2016)
Imaging Postoperative Bile Leaks and Assessing Integrity of Biliary-Enteric Anastomoses With Fusion HIDA SPECT/CT Scintigraphy
Authors: Kok Tian Yue, Kei Pin Lin, Anthony Goh Soon Whatt
Journal: Clinical Nuclear Medicine (2010)

Bile leak is not an infrequent complication after hepatobiliary surgery and is a significant source of postoperative morbidity and mortality. Hepatobiliary scintigraphy is an established technique for detection of bile leaks, but suffers from limited spatial resolution and lack of anatomic correlation inherent in all planar imaging. We present cases where adjunct SPECT/CT proved useful, particularly in differentiating postoperative fluid collections from bile and evaluating the integrity of biliary-enteric anastomoses.
Medicine and chiropractic
Authors: H. T. Ballantine
Journal: JAMA (1967)

For the past 53 years a well-organized and determined band of practitioners has importuned the state legislatures of this country for permission to administer to the health needs of the people. Their efforts have been so successful in the political arena that 48 states license them. These individuals call themselves chiropractors. Their aggregate number is variously estimated at from 15,000 to 25,000, and it is claimed that about 4 million people consult them in any one year. In 1966, the American Chiropractic Association published a brochure entitled<i>What Medicine Really Thinks About Chiropractic</i>.<sup>1</sup>The authors were C. W. Weiant "dean emeritus of the Chiropractic Institute of New York" and S. Goldschmidt, "member Special Committee on Political Education, American Chiropractic Association." Two statements in their introduction to a defense of chiropractic present the salient points to be dealt with here. The first reads as follows: In this brochure we present
Plasma GABA levels in chronic alcoholics
Authors: J A Coffman, F Petty
Journal: American Journal of Psychiatry (1985)

Ethanol intoxication has been noted to cause marked changes in brain and CSF levels of gamma-aminobutyric acid (GABA). Using plasma GABA levels to assess brain GABA activity, the authors found that 85 chronic alcoholics had significantly lower levels than control subjects.
Vertigo
Authors: J Kanagalingam, D Hajioff, S Bennett
Journal: BMJ (2005)

#### Useful reading Hanley K, O'Dowd T, Considine N. Asystematic review of vertigo in primary care. Br J Gen Pract 2001;51: 666-71 Hilton M, Pinder D. The Epley (canalith repositioning) manoeuvre for benign paroxysmal positional vertigo. Cochrane Database Syst Rev 2002;(1): CD003162 A 60 year old woman reports sudden dizziness when she arises from bed. She feels nauseous and had been vomiting. She recently had a severe cold. Her vomiting has settled, but she is dizzy on turning her head to the right. She is frightened to leave her house. Taking a history —Dizziness means different things to different patients. Elicit a precise description of her symptoms by providing alternatives: Does the room spin around (vertigo)? Do you feel unsteady (dysequilibrium)? Do you feel like you may faint (presyncope)? Do you feel lightheaded?