tbuckley/cabot-search huggingface dataset:
Psychotherapist-patient sexual contact after termination of treatment: an analysis and a proposal
Authors: P S Appelbaum, L Jorgenson
Journal: American Journal of Psychiatry (1991)

Controversy over the legitimate extent, if any, of sexual contact between psychotherapists and former patients remains intense. In this paper the authors review current approaches to controlling posttermination sexual contact, offer a conceptual framework within which the problematic aspects of therapist-patient sex both during and after treatment can be understood, and develop a set of recommendations for policies that balance the goals of protecting former patients and avoiding unnecessary interventions into consensual relationships. Review of ethical, legal, and administrative controls on posttermination sex revealed considerable heterogeneity of approaches, which appeared to be based on confusion concerning the rationale for restriction. An analysis of the problems with therapist-patient sexual contact suggests four areas of concern: impaired decision making, coercion, fraud, and exploitation of a fiduciary relationship. The nature and magnitude of these problems differ in pre- and posttermination sexual relationships. The authors conclude that clarity of restrictions on posttreatment sex is important, but an absolute ban is not essential to protecting former patients. Rather, a 1-year waiting period after termination, during which even social contact would be precluded, should minimize problems and allow former patients and therapists to enter into intimate relationships. The authors discuss the advantages and disadvantages of this approach over other approaches.
Diabetes mellitus in people with schizophrenia, bipolar disorder and major depressive disorder: a systematic review and large scale meta‐analysis
Authors: Davy Vancampfort, Christoph U. Correll, Britta Galling, Michel Probst, Marc De Hert, Philip B. Ward, Simon Rosenbaum, Fiona Gaughran, John Lally, Brendon Stubbs
Journal: World Psychiatry (2016)

Type 2 diabetes mellitus (T2DM) is highly predictive of cardiovascular diseases and can have particularly deleterious health impacts in people with severe mental illness (SMI), i.e. schizophrenia, bipolar disorder or major depressive disorder. This meta‐analysis aimed: a) to describe pooled frequencies of T2DM in people with SMI; b) to analyze the influence of demographic, illness and treatment variables as well as T2DM assessment methods; and c) to describe T2DM prevalence in studies directly comparing persons with each specific SMI diagnosis to general population samples. The trim and fill adjusted pooled T2DM prevalence among 438,245 people with SMI was 11.3% (95% CI: 10.0%‐12.6%). In antipsychotic‐naïve participants, the prevalence of T2DM was 2.9% (95% CI: 1.7%‐4.8%). There were no significant diagnostic subgroup differences. A comparative meta‐analysis established that multi‐episode persons with SMI (N=133,470) were significantly more likely to have T2DM than matched controls (N=5,622,664): relative risk, RR=1.85, 95% CI: 1.45‐2.37, p&lt;0.001. The T2DM prevalence was consistently elevated in each of the three major diagnostic subgroups compared to matched controls. Higher T2DM prevalences were observed in women with SMI compared to men (RR=1.43, 95% CI: 1.20‐1.69, p&lt;0.001). Multi‐episode (versus first‐episode) status was the only significant predictor for T2DM in a multivariable meta‐regression analysis (r 2 =0.52, p&lt;0.001). The T2DM prevalence was higher in patients prescribed antipsychotics, except for aripriprazole and amisulpride. Routine screening and multidisciplinary management of T2DM is needed. T2DM risks of individual antipsychotic medications should be considered when making treatment choices.
Case 46-1975
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, J. Warren Harthorne, David G. Freiman
Journal: New England Journal of Medicine (1975)

Presentation of CaseA 37-year-old white man was admitted to the Beth Israel Hospital because of dyspnea.He was in excellent health until eight years previously, when he experienced a transitory episode of right facial weakness, confusion and aphasia. An x-ray film of the chest showed slight cardiac enlargement; an electrocardiogram revealed marked left-axis deviation; the PR interval was 0.18 second, and the QRS interval was 0.12 second. Anticoagulant treatment was begun. He was admitted to another hospital, where right-sided cardiac catheterization disclosed no evidence of valvular or congenital heart disease; the intracardiac pressures were normal at rest, but on . . .
Importance of akinesia: plasma chlorpromazine and prolactin levels
Authors: T Van Putten, P R May, J N Wilkins
Journal: American Journal of Psychiatry (1980)

Akinesia, a common side effect of antipsychotic drugs, often goes unrecognized by physician and patient. Akinetic apathy and lack of spontaneity can be mistaken for the negative symptoms of schizophrenia and add to the well-known social and emotional disability of schizophrenic patients on maintenance therapy. The authors attempted to identify a measure that might distinguish between akinesia and the negative symptoms of schizophrenia but found no relationship between plasma and saliva chlorpromazine levels or prolactin levels and akinesia. The fact that all of the akinetic but only 31% of the nonakinetic patients rated themselves as drowsy 12 hours after their bedtime dose indicates that drowsiness is a fairly accurate correlate of akinesia.
The Nonselective Cytotoxic Cell (N Cell) 2
Authors: Masahiro Kiuchi, Mitsuo Takasugi
Journal: JNCI Journal of the National Cancer Institute (1976)

Journal Article The Nonselective Cytotoxic Cell (N Cell) Get access Masahiro Kiuchi, Masahiro Kiuchi 3Department of Surgery, School of Medicine, University of California, Los Angeles, Calif. 90024. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mitsuo Takasugi Mitsuo Takasugi 4We thank Ms. Susan Johnston, Ms. Annie Ramseyer, Mr. Robert Ivler, Ms. Donna Akira, and Mrs. Minami Hardiwijaja for their expert technical assistance. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 56, Issue 3, March 1976, Pages 575–582, https://doi.org/10.1093/jnci/56.3.575 Published: 01 March 1976 Article history Received: 07 July 1975 Accepted: 03 October 1975 Published: 01 March 1976
AB0777 Work Productivity Associated with Disease Activity and Functional Ability in Italian Patients with Axial Spondyloarthritis: Results for Space-Cohort:
Authors: M. Lorenzin, M. de Hooge, P. Frallonardo, A. Ortolan, L. Punzi, R. Ramonda
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Several studies show that work productivity is related to disease activity and functional ability in patients with axial spondyloarthritis (axSpA). Also socioeconomic status of patients can have an impact on the work productivity. However, these are studies in patients with sustained axSpA. <h3>Objectives</h3> Investigate work productivity and wheter there is a correlation with disease activity in Italian patients with early axSpA. <h3>Methods</h3> Baseline data was used of patients with BP (≥3 months, ≤2 years, onset &lt;45 years) of unknown origin included by the Italian center of the SPACE cohort. Patients were diagnosed by the treating rheumatologist. Work productivity was measured by the Work Productivity and Activity Impairment (WPAI) questionnaire. Absenteeism (work absence due to illness), presenteeism (reduced productivity while at work) and work productivity loss (WPL, combining absenteeism and presenteeism) over past week were reported. Disease activity was assessed by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI; low (&lt;4) and high (≥4) disease activity) and Ankylosing Spondylitis disease activity score (ASDAS; inactive disease (&lt;1.3), moderate disease (1.3-2.1), high disease (2.1-3.5) and very high disease activity (&gt;3.5)). Functional ability was assessed by Bath Ankylosing Spondylitis Functional Index (BASFI; high (&lt;2.5) and low (≥2.5) functional ability). <h3>Results</h3> Out of 51 patients 21 are male (41.2%), average age at onset back pain is 29.7 (±8.7) years, average duration of back pain is 12.9 (±8.7) months, 16 (31.4%) are HLA-B27+ and 48 (94.1%) have IBP. Average scores for BASDAI (4.5±2.6), ASDAS (2.3±1.0) and BASFI (1.7±2.1) are found. There are 16 patients doing only unpaid activities and 35 patients have paid jobs, of which 6 patients combine this with unpaid activities. On average patients work 36.4 hours/week, absenteeism is 8.3%, presenteeism 28.6% and WPL 33.7%. Presenteeism is statistically significant different between patients with paid (32.6%) and unpaid (18.6%) work. Absenteeism (paid; 7.9% and unpaid; 8.3%) and WPL (paid; 36.6% and unpaid; 25.6%) are not. A decrease in work productivity is seen with an increase in disease activity and functional ability. Correlations are found between disease activity (ASDAS/BASDAI) and absenteeism (β=6.08**/2.65**), presenteeism (β=16.04**/5.80**) and work productivity loss (β=18.86***/7.12***). Also functional ability and absenteeism (β=4.32***), presenteeism (β=4.62*) and work productivity loss (β=7.31***) are correlated. *p&lt;0.05**p&lt;0.01***p&lt;0.00 <h3>Conclusions</h3> Work productivity impairment is related to disease activity and functional ability in Italian patients with early onset of axSpA. <h3>Disclosure of Interest</h3> None declared
Changing epidemiology of meningococcal disease in Spain, 1989-1997
Authors: S Mateo, R Cano, C García
Journal: Eurosurveillance (1997)

In the 1980s, the presentation of meningococcal disease in Spain was closely linked to the predominance of serotype B. Since the early 1990s however, an increasing number of serotype C strains have been isolated from a number of localities in the west of
AB0152 Evaluation of Semaphorine 3A, Sclerostin and Bone Morphogenic Protein 2 in Patients with Axial Spondyloarthritis
Authors: F.M. Perrotta, F. Ceccarelli, F. Spinelli, M. Montepaone, T. Colasanti, C. Barbati, G. Valesini
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Mechanism of new bone formation in axial Spondyloarthritis (axSpA) is still not fully understood. Signal pathways implicated in bone metabolism such as semaphorins/NP-1, Wnt/beta-catenin, bone morphogenic proteins and RANK/RANKL system seems to be associated with radiographic progression of the disease and potentially target for the therapy. <h3>Objectives</h3> The aim of the study was to assess serum levels of semaphorine 3A (SEMA 3A), sclerostin and bone morphogenic protein 2 (BMP-2) in patients with axSpA and to assess the relationship with disease activity parameters and radiological index of damage. <h3>Methods</h3> Consecutive patients with axSpA fulfilling ASAS criteria and 20 age and sex-matched healthy controls were enrolled. Ankylosing Spondylitis Disease Activity Score-C reactive protein (ASDAS-CRP), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were used as additional disease activity measures. Bath Ankylosing Spondylitis Metrology Index (BASMI) was used to assess spinal mobility. Lateral spine radiographs, collected within 6 months, were scored by using the modified Ankylosing Spondylitis Spine Score (mSASSS) for chronic axSpA-related changes. Serum level of SEMA 3A, sclerostin and BMP-2 were evaluated using commercial ELISA kit in all patients and controls. <h3>Results</h3> We enrolled 20 axSpA patients [M/F: 14/6; age (median/25°-75° percentile) 50.5/40.5-54.75 years; disease duration (median/25°-75° percentile) 11/6.75-20 years]. Sclerostin serum levels were significantly lower in axial SpA patients compared to healthy control (p=0.002); serum levels of SEMA 3A and BMP-2 did not statistically differ among patients and controls. Moreover SEMA 3A serum levels showed a positive correlation with mSASSS (rho 0.41; p=0.04) and a negative correlation with ESR (rho -0.44; p=0.04). We did not find any correlations between serum levels of BMP-2 and disease activity and disability indices. <h3>Conclusions</h3> Our pilot study showed that serum levels of sclerostin, an inhibitor of bone formation through Wnt/beta-catenin pathway, were low in patients with axSpA, according to previous studies. Moreover, the correlation of SEMA 3A serum levels with radiographic damage corroborate the hypothesis that these proteins, and the relative pathways, could be implicated in new bone formation in axSpA. <h3>Disclosure of Interest</h3> None declared
SAT0509 Clinical and Serological Profile of Children with Positive SSA-Ro/SSB-La Antibodies
Authors: J.G. Ovalles-Bonilla, J.C. Nieto, J. Martinez-Barrio, F.J. Lopez-Longo, I. Janta, E. Naredo, C.M. Gonzalez, M.C. Hinojosa, N. Bello, B. Serrano, C. Mata-Martinez, R. Gonzalez, C. Saenz, I. Monteagudo, D. Hernandez, L. Valor, L. Carreño
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Several studies have shown the relationship between anti-SSA-Ro/SSB-La antibodies and Systemic Lupus Erythematosus (SLE), Sjögren Syndrome (SS) and other autoimmune diseases in adult population. However, the expression of these autoantibodies and clinical correlation in juvenile patients is poorly described. <h3>Objectives</h3> To characterize the clinical and serological profile and primary rheumatic diseases in pediatric patients with positive anti-SSA-Ro and/or anti-SSB-La antibodies. <h3>Methods</h3> The data was obtained from a long term prospective cohort of patients under age 18 diagnosed with rheumatic diseases in a tertiary hospital in Spain. Demographic, clinical, and laboratory data were collected from 1986 to 2010. Patients were divided into 2 groups: anti-SSA-Ro/SSB-La positive and anti-SSA-Ro/SSB-La negative. <h3>Results</h3> A total of 187 patients were tested for anti Extractable Nuclear Antigens (ENA), with a following mean time of 11 years. Mean age at disease onset was 12.6 years and 77% were female. Fifty-four (28.9%) anti-SSA-Ro/SSB-La positive subjects were compared against 133 (71.1%) anti-SSA-Ro/SSB-La negative subjects. Among positive cases, 13 (24.1%) patients were double-positive for anti-SSA-Ro and anti-SSB-La, 51 (94.4%) were positive for anti-SSA-Ro and 3 (5.5%) were single-positive for anti-SSB-La. The anti-SSA-Ro/SSB-La antibodies were found less frequently (p=0.003) in the overlapping syndromes, and more frequently in SLE (p=0.007). In addition rheumatoid factor (p&lt;0.001), anti-Sm (p&lt;0.001) and anti-RNP (p&lt;0.001) were frequently co-expressed with anti-SSA-Ro/SSB-La antibodies. Finally the anti-SSA-Ro/SSB-La positive group presented more hematological and skin manifestations than the negative group (p&lt;0.05). <h3>Conclusions</h3> Similarly to adults, we observed a relationship between anti-SSA-Ro/SSB-La antibodies and SLE in pediatric patients. However a low proportion of childhood primary SS exists in our anti-SSA-Ro/SSB-La positive cases. This could be explained by underdiagnoses related to the atypical clinical presentation of SS in pediatric population. Single-positive anti-SSB-La patients are uncommon, the clinical significance of this serological result remains uncertain in children. <h3>References</h3> Rheumatol Int (2014) 34:1123–1127. <h3>Disclosure of Interest</h3> None declared
PWE-026 Role of pyloric and duodenal self expandable metal stents (sems) for malignant gastric outflow obstruction in palliative patients
Authors: M Murgatroyd, J Iqbal, H Kaltsidis, L Hodges, S Mahmood
Journal: Gut (2015)

<h3>Introduction</h3> Stent placement for malignant gastric outflow obstruction (GOO) is recommended for palliative management for patients with unresectable disease. Gastrojejunostomy is an alternative but may not be appropriate due to poor performance status and prognosis. Endoscopic SEMS for GOO is less invasive and has been shown to be safe and effective method for relieving symptoms of GOO. Previously reported endoscopic success rate of GOO stenting is 92–100%.<sup>1</sup> Our aim was to assess the safety and efficacy of pyloric and duodenal stents (SEMS) for gastric outflow obstruction caused by malignancy. <h3>Method</h3> Retrospective audit between Jan 2012 to Dec 2014, reviewing medical notes and electronic patient records. All procedures were performed using Through the Scope (TTS) technique and fluoroscopic guidance. End-points were technical success (correct SEMS placement confirmed radiologically and endoscopically at time of procedure) and clinical success (resolution of obstructive symptoms, resumption of oral diet). <h3>Results</h3> 63 patients were identified (median age 71 years). 50 patients (79%) had malignant stricture due to primary cancers (gastric 33%, pancreatic 25%). 13 patients had GOO from metastases (20%). Median ASA grade was 3. <h3>Procedural Success</h3> 4 patients did not require stent placement when evaluated endoscopically. Of the remaining 59 patients 55 were stented successfully (93.2%). In 4 patients stents could not be deployed as stricture could not be traversed with wire or cannula. Of the 55 patients who were stented clinical success was 96% (2 patients needed repeat procedure within one week). 13 patients (25%) required further interventions due to stent blockage from tumour ingrowth or food debris and all successfully managed with restenting. The mean time for further intervention 98 day. 83 procedures were carried in total with an overall success rate of 95.2%. There were no major complications reported, no perforation or procedure related mortality. Two patient had stent migrated proximally into stomach and one patient needed repeat procedure due to lack of stent expansion, all managed with successful restenting. <h3>Survival</h3> 78% were alive at 30 days, 32% were alive at 6 month with 4 patients yet to reach 6 month end point, 33% alive at 1 year. <h3>Conclusion</h3> Stenting for GOO is a safe procedure and avoids the need for surgical gastroenterojejunostomy in over 93% of palliative patients. Stent dysfunction can happen due to tumour overgrowth, food debris or stent migration. In our study all 25% of patients needing reintervention within 4 months were successfully managed with restenting. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Gaidos JKJ. Treatment of malignant gastric outlet obs truction with endoscopically placed self -expandable metal stents. World J Gastroenterol 2009;15(35):4365–4371
Sodium Reduction—Saving Lives by Putting Choice Into Consumers’ Hands
Authors: Thomas R. Frieden
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of electrode placement on the efficacy of titrated, low-dose ECT
Authors: H A Sackeim, P Decina, M Kanzler, B Kerr, S Malitz
Journal: American Journal of Psychiatry (1987)

This double-blind, random-assignment study contrasted the relative efficacy of bilateral and unilateral right ECT with a low-dose titration procedure. In 52 patients with primary major depressive disorder, bilateral ECT was markedly superior in short-term symptom reduction to unilateral right ECT. The two conditions did not differ in the duration of generalized seizures or in the number of treatments administered to achieve clinical response. The findings challenge the claim that the elicitation of generalized seizure is, in and of itself, sufficient for the antidepressant properties of ECT. Rather, a dose in excess of seizure threshold may contribute to the efficacy of ECT, particularly with a unilateral right electrode placement.
Purification and Molecular Cloning of SH2- and SH3-Containing Inositol Polyphosphate-5-Phosphatase, Which Is Involved in the Signaling Pathway of Granulocyte-Macrophage Colony-Stimulating Factor, Erythropoietin, and Bcr-Abl
Authors: Hideharu Odai, Ko Sasaki, Akihiro Iwamatsu, Tetsuya Nakamoto, Hiroo Ueno, Tetsuya Yamagata, Kinuko Mitani, Yoshio Yazaki, Hisamaru Hirai
Journal: Blood (1997)
Lymphocyte cholecystokinin concentrations in panic disorder
Authors: F Brambilla, L Bellodi, G Perna, A Garberi, A Panerai, P Sacerdote
Journal: American Journal of Psychiatry (1993)

Since cholecystokinin (CCK) is known to be anxiogenic in experimental animals and to induce panic attacks in humans, lymphocyte CCK-8 concentrations were measured in 15 patients with panic disorder and 15 age- and sex-matched healthy subjects. The patients' levels were measured again after a 30-day course of alprazolam therapy, 1.5 mg/day. The CCK-8 concentrations were significantly lower in the patients than in the control subjects and did not change after alprazolam therapy. There was no correlation between the peptide values and levels of anxiety or frequency and severity of panic attacks.
Combined Analysis of an Rna Cell Cycle Progression (Ccp) Score for Predicting Prostate Cancer Death in Two Conservatively Managed Needle Biopsy Cohorts
Authors: J. Cuzick, S. Stone, G. Fisher, B.V. North, D. Berney, L. Beltran, D. Greenberg, H. Moller, J.E. Reid, A. Gutin, J.S. Lanchbury, M. Brawer, P. Scardino
Journal: Annals of Oncology (2014)
Unusual Hydrolipotropic Shifts in the Spleen of Albino Rats Bearing Walker Carcinosarcoma 256&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn2"&gt;3&lt;/xref&gt;
Authors: Eldon M. Boyd, H. Douglas McEwen, Monica E. Murdoch
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Unusual Hydrolipotropic Shifts in the Spleen of Albino Rats Bearing Walker Carcinosarcoma 256, Get access Eldon M. Boyd, Eldon M. Boyd Department of Pharmacology, Queen's University, Kingston, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Douglas McEwen, H. Douglas McEwen Department of Pharmacology, Queen's University, Kingston, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar Monica E. Murdoch Monica E. Murdoch Department of Pharmacology, Queen's University, Kingston, Ontario, Canada Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 4, February 1956, Pages 913–925, https://doi.org/10.1093/jnci/16.4.913 Published: 01 February 1956 Article history Received: 13 June 1955 Published: 01 February 1956