tbuckley/cabot-search huggingface dataset:
Unsettled Outlook
Authors: John Lister
Journal: New England Journal of Medicine (1979)

AS anticipated, the Review Body on Doctors' and Dentists' Remuneration1 has now recommended generous increases in salary for all doctors working in the National Health Service (NHS). The average increase will be about 25 per cent, but hospital consultants and specialists who had hoped that their open-ended contract would be replaced by a new type of contract that would reflect the varying workload of different specialists have been disappointed because their negotiators2 found the pricing of the new contract by the Review Body to be quite unacceptable. This was much regretted by the negotiators, who have been striving for two . . .
Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline
Authors: Alok A. Khorana, Pamela B. Mangu, Jordan Berlin, Anitra Engebretson, Theodore S. Hong, Anirban Maitra, Supriya G. Mohile, Matthew Mumber, Richard Schulick, Marc Shapiro, Susan Urba, Herbert J. Zeh, Matthew H.G. Katz
Journal: Journal of Clinical Oncology (2016)

To provide evidence-based recommendations to oncologists and others on potentially curative therapy for patients with localized pancreatic cancer.ASCO convened a panel of medical oncology, radiation oncology, surgical oncology, palliative care, and advocacy experts and conducted a systematic review of literature from January 2002 to June 2015. Outcomes included overall survival, disease-free survival, progression-free survival, and adverse events.Nine randomized controlled trials met the systematic review criteria.A multiphase computed tomography scan of the abdomen and pelvis or magnetic resonance imaging should be performed for all patients to assess the anatomic relationships of the primary tumor and for the presence of intra-abdominal metastases. Baseline performance status, comorbidity profile, and goals of care should be evaluated and established. Primary surgical resection is recommended for all patients who have no metastases, appropriate performance and comorbidity profiles, and no radiographic interface between primary tumor and mesenteric vasculature. Preoperative therapy is recommended for patients who meet specific characteristics. All patients with resected pancreatic cancer who did not receive preoperative therapy should be offered 6 months of adjuvant chemotherapy in the absence of contraindications. Adjuvant chemoradiation may be offered to patients who did not receive preoperative therapy with microscopically positive margins (R1) after resection and/or who had node-positive disease after completion of 4 to 6 months of systemic adjuvant chemotherapy. Patients should have a full assessment of symptoms, psychological status, and social supports and should receive palliative care early. Patients who have completed treatment and have no evidence of disease should be monitored. Additional information is available at www.asco.org/guidelines/PCPC and www.asco.org/guidelineswiki.
Ovarian cancer: what is poor prognosis disease?
Authors: M H Cohen
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.7.1287 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2113572 Ovarian cancer: what is poor prognosis disease? M H CohenxM H CohenSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.7.1287 PDF "Ovarian cancer: what is poor prognosis disease?." Journal of Clinical Oncology, 8(7), pp. 1287–1288© 1990 by American Society of Clinical Oncology
Report on the Sixth International Meeting of the European Laboratory Working Group on Diphtheria, Brussels, Belgium
Authors: S Lai, A Efstratiou
Journal: Eurosurveillance (2002)

In addition to the Eastern European resurgence of diphtheria during the last decade, there has also been an emergence of infections caused by non-toxigenic Corynebacterium diphtheriae and non-toxigenic, toxin gene bearing C. diphtheriae. Given that these strains may manifest as symptomatic infections of differing degrees of severity, their clinical and epidemiological significance need to be assessed. The persistence of toxigenic and non-toxigenic C. diphtheriae in circulation, together with genotypic and biotype variability means that innovative measures to vaccinate populations are pertinent. The most effective method of protecting the currently most vulnerable population group (adults) is to implement a booster dose of vaccine amongst the adult populations. Furthermore, in combination with an efficient surveillance system, effective antibiotic prophylaxis and an up-to-date vaccination programme, serological studies needs to be maintained to monitor the immunity status of the population.
Regulation of Respiration
Authors: Albert J. Berger, Robert A. Mitchell, John W. Severinghaus
Journal: New England Journal of Medicine (1977)

Central Respiratory ControllerThe respiratory controller, located within the CNS, is composed of two functionally and anatomically separate elements. Voluntary respiration is governed primarily by the cortex, and automatic respiration by structures within the brain-stem. The spinal cord functions to integrate the output of these two subsystems. Early studies employed the technics of destruction and gross electrical stimulation of various neural structures to determine the role of these elements in the neural regulation of respiration. Recent studies, involving application of neurophysiologic and histologic technics, have led to much new information concerning the function and organization of the brain-stem in respiration . . .
Expression of a Cell Surface Antigen Recognized by the Monoclonal Antibody AUA1 in Bladder Carcinoma: An Immunohistochemical Study
Authors: J. Zorzos, A. Zizi, A. Bakiras, D. Pectasidis, D.V. Skarlos, H. Zorzos, J. Elemenoglou, M. Likourinas
Journal: European Urology (1995)
PWE-098 Increase in gut permeability is an early event in cirrhosis and is not associated with bacterial translocation, systemic inflammation or clinical features: a prospective longitudinal study
Authors: F Figorilli, J Macnaughtan, A Moratalla, RP Mookerjee, N Davies, R Jalan
Journal: Gut (2015)

<h3>Introduction</h3> In cirrhosis, bacterial translocation (BT) is an early event and predicts occurrence of complications such as infection and mortality. In advanced liver failure, this is associated with increased gut permeability (GP) but the data in well-compensated cirrhosis is lacking. The aim of this study was to determine whether (a) GP is altered in patients with well-compensated cirrhosis (b) this was associated with bacterial translocation and (c) complications of cirrhosis. <h3>Method</h3> Fifty-two stable cirrhotic patients (male: 33; age: 57, 1 ± 8, 36; Child A: 84, 6%, Child B: 15, 4%) were included and studied longitudinally at the time of inclusion and 1-month afterwards. Clinical and biochemical variables and complications were recorded. GP was measured using standard sugar probe-based assays. Bacterial DNA was measured in serum samples by PCR reaction for the 16S ribosomal RNA gene. <h3>Results</h3> 19 patients (36, 5%) had an abnormal GP (&gt;0,033). There are no differences in gender, age, aetiology; diabetes, WCC, MELD (9, 0 ± 2, 7 vs 9, 4 ± 3, 5) and complications of cirrhosis (infection: 18, 2% vs 10.5%, ascites: 54, 5% vs 31, 6%; HE 15, 2% 10, 5% and varices: 42, 4% vs 52, 6%). Only 2 patients showed evidence of BT. At 1-month, in patients with a GP &lt;0,033, 69% showed an increase, 7 (24, 1%) a decrease and 2 were unchanged in the GP rate. In patients with abnormal GP, it worsened in 31, 3% and in 68, 7% it improved. The two patients that showed evidence of BT became negative after one month and both of them displayed an improvement of their GP. 3-patients became positive after 1-month, with two showing worsening of GP. Conversely, all of these changes were not associated with any complications of cirrhosis. <h3>Conclusion</h3> The data of this prospective longitudinal study shows that alteration in GP occurs in a third of wellcompensated cirrhosis and is a dynamic abnormalities that improves or worsens with no apparent clinical sequaela. Increased GP is not associated with evidence of bacterial translocation, clinical characteristics or systemic inflammation in well-compensated cirrhosis. It is likely that increased gut permeability is an early event but bacterial translocation in humans occurs late and factors other than translocated bacteria such as its products or metabolites contribute to clinical manifestations. <h3>Disclosure of interest</h3> None Declared.
Heterogeneity and Peculiarities Of a Small Series Of Patients Affected By Paroxysmal Nocturnal Hemoglobinuria Treated With Eculizumab
Authors: Stefano Pulini, Giuseppina Ricciuti, Simona Sestili, Gaetano La Barba, Antonella Sau, Giuseppe Fioritoni, Paolo Di Bartolomeo
Journal: Blood (2013)
An outbreak of Norwalk like virus gastroenteritis in a nursing home in Rotterdam
Authors: O Ronveaux, D Vos, A Bosman, K Brandwijk, J Vinjé, M Koopmans, R Reintjes
Journal: Eurosurveillance (2000)

Sixty-two per cent of elderly and disabled residents of a Dutch nursing home (74/120) and 32% of staff (33/102) became ill in an outbreak of Norwalk-like viral gastroenteritis. The outbreak spread from person to person was supported by temporal clustering
AB0824 Predictors of Cerebrovascular Disease Among Psoriatic Arthritis Patients
Authors: R. Queiro, B. Acasuso, I. Morante, I. Cabezas, P. Tejόn, M. Alperi, L. Arboleya, J.L. Riestra, J. Ballina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patients with psoriasis and psoriatic arthritis (PsA) have a higher prevalence of cardiovascular risk factors (CVRF) compared with normal population. Because of this, they also have higher risk of developing coronary heart disease, however the frequency and predictors of cerebrovascular disease have not been sufficiently studied in these populations. <h3>Objectives</h3> To analyze the frequency and determinants of cerebrovascular disease in a cohort of patients with PsA. <h3>Methods</h3> Retrospective cohort study that included 205 patients with PsA (CASPAR criteria) of a single university institution. Cerebrovascular disease was defined as any transient or permanent event as a result of a disorder of cerebral circulation either ischemic or hemorrhagic diagnosed by a neurologist. The variables included were: age, sex, education level, age at onset of disease, family history, type and severity of psoriasis, HLA-B*27 and C*06, articular pattern, classic CVRF, BMI, and medication. Univariate and multivariate analyses were performed. All patients gave informed consent. An institutional ethics committee approved the final version of this study. <h3>Results</h3> Of the 205 patients enrolled, 9 (4.4%) had cerebrovascular disease (6 ischemic stroke, 2 transient and one hemorrhagic stroke). In the univariate analysis, these patients had a low educational level (100% vs. 40.3% p=0.003), pustular psoriasis (33.3% vs. 3.6%, p&lt;0.0001), and erythrodermic (11.1% vs. 2%, p=0.05), polyarthritis as debut (77.8% vs. 36.7%, p=0.013), diabetes (66.7% vs. 9.7%, p&lt;0.0001), hypertension (77.8% vs. 28.6%, p=0.002), dyslipidemia (55.6% vs. 29.6%, p=0.05), ischemic heart disease (44.4% vs. 2.6%, p&lt;0.0001) and peripheral vascular disease (33.3% vs. 1.5%, p&lt;0.0001). In multivariate analysis, the predictors of cerebrovascular disease were: pustular psoriasis (OR 10.9, 95% CI: 1.2-100.2, p=0.034), erythrodermia (OR 31.2, 95% CI: 1.8-540.5, p=0.019), polyarticular onset (OR 7.8, 95% CI: 1.06-57.3, p=0.044), diabetes (OR 9.7, 95% CI: 1.60-58.9, p=0.013) and ischemic heart disease (OR 23, 95% CI: 3.07-172.2). <h3>Conclusions</h3> Cerebrovascular disease is common in PsA. Patients with the most severe phenotypes of psoriatic disease are at high risk for developing cerebrovascular disease. Also, patients who are older at PsA onset and those with other CV comorbidities are a high risk group for stroke. <h3>Disclosure of Interest</h3> None declared
Prospective Validation of the Lupus Impact Tracker: A Patient‐Completed Tool for Clinical Practice to Evaluate the Impact of Systemic Lupus Erythematosus
Authors: Meenakshi Jolly, Mark Kosinski, Cindy P. Garris, Alan K. Oglesby
Journal: Arthritis & Rheumatology (2016)

Objective To evaluate the reliability, validity, responsiveness, and utility of the Lupus Impact Tracker (LIT). Methods This was a prospective longitudinal study with 20 North American sites participating. Consenting patients completed the LIT, Medical Outcomes Study Short Form 36 (version 2), Patient Health Questionnaire 9 (PHQ‐9), LupusQoL, and patient LIT feedback questionnaire. Rheumatologists completed the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index, and physician LIT feedback questionnaire. The reliability, convergent validity, construct validity, and responsiveness of the LIT were evaluated. Results Of the 325 SLE patients enrolled, 90% were female, 53% were white, and 33% were African American. Their mean age was 42 years. The mean ± SD baseline physician's global assessment and total SELENA–SLEDAI scores were 1.04 ± 0.8 and 4.28 ± 3.8, respectively, while 3‐month scores were 0.94 ± 0.73 and 4.09 ± 3.79, respectively. Internal consistency reliability was high (&gt;0.9) at both visits. LIT scores correlated highly with other measures of patient‐reported outcomes, and construct validity was established against clinical measures. The LIT was highly responsive to patient‐reported changes in SLE health status; however, LIT scores were not as responsive to changes in the SELENA–SLEDAI score. The majority of patients and physicians found LIT to be acceptable and feasible to administer in a clinical setting. Conclusion The LIT is a reliable and valid instrument for assessing the impact of SLE on patients and captures unique and important information not included in physician assessments of disease. It may be useful in clinical practice to facilitate communication between the physician and the patient and enable efficient incorporation of the patient's perspective in disease management.
Managing patients with an absent or dysfunctional spleen
Authors: M R Workman, J Philpott-Howard, A J Bellingham
Journal: BMJ (1996)

EDITOR,-The clinical evaluation of the acute scrotum in children is difficult, but I have yet to see a study correctly evaluating the value of radionuclide isotope imaging solely in this population.All of the studies quoted by C J Luscombe and colleagues have been performed predominantly in adults.Children are uncooperative, and their testes are smaller, which must increase the diagnostic error.For instance, in a large series of children with an acute scrotum Lewis et al reported a sensitivity of 95.4% and a specificity of 85.7% for radionu- clide imaging,' which is not as clear cut as Luscombe and colleagues imply.Fenner et al, whom Luscombe and colleagues cite, stated, "We believe its [radionuclide imaging's] routine use in clinical practise is limited" and "would result in needless delays and unjustifiable expense."2This is from advocates of the technique.There is no doubt that delay in surgery results in ischaemia, infarction, and testicular loss.Any diagnostic strategy has to be designed with this as the bottom line.If a nuclear medicine department can perform and report such an investigation within an hour of a request being made by the accident and emergency department, pre- sumably at any time of the day or night, then the investigation may have a role.If the department cannot do this then rapid exploration is the option that is safest (to the testicle).The economic argument is spurious: one false negative scan leading to legal action will wipe out any pecuniary advantage.
TP53 Disruption and Telomere Instability In Chronic Lymphocytic Leukemia
Authors: Mélanie Pagès, Lauren Veronese, Patricia Combes, Romain Guièze, Gwendoline Soler, Nolwen Prie, Mary Callanan, Philippe Vago, Jacques-Olivier Bay, Olivier Tournilhac, Andrei Tchirkov
Journal: Blood (2013)
Inhibition of Tumor Necrosis Factor α and Ankylosing Spondylitis
Authors: Helena Marzo-Ortega, Paul Emery, Dennis McGonagle
Journal: New England Journal of Medicine (2003)

Thrombolytic Therapy in Patients with Submassive Pulmonary Embolismto the editor: Konstantinides et al. (Oct.10 issue) 1 evaluated the role of alteplase in patients with submassive pulmonary embolism.Their findings will be regarded by many as definitive evidence in support of the use of thrombolytic agents in such patients.However, a review of the study design, particularly the end points chosen, shows that the data do not support the authors' conclusions.The only primary end point to show significant improvement was an escalation of treatment for clinical deterioration -nearly always meaning treatment with open-label alteplase, the drug used in the intervention group.The decision to escalate treatment was made by clinicians, who were permitted to break the randomization code first; thus, the primary end point in a given case could be determined by an unblinded provider.Escalation of treatment would have been unlikely in a patient with clinical deterioration who was in the alteplase group but would have been likely in a patient with similar deterioration who was in the placebo group.The study suggests that the number needed to treat was nine; in other words, nine patients would have to be given alteplase to avoid treatment escalation (i.e., use of open-label alteplase) in one patient.In view of the 1 percent risk of major hemorrhage with thrombolysis, 2 avoiding open-label use in one patient hardly justifies preemptive use of the drug in many more patients.
An outbreak of cryptosporidiosis in the Netherlands
Authors: I. A. van Asperen, T Mank, G. J. Medema, C Stijnen, A S de Boer, J. F. Groot, P TenHam, J. F. Sluiters, M W Borgdorff
Journal: Eurosurveillance (1996)

A hospital microbiologist in Spijkenisse, in the south west of the Netherlands - who had recently attended a parasitology course - identified cryptosporidial oocysts in stools from a patient with diarrhoea on 16 August 1995. Re-examination of 89 stool spe
PWE-100 A clinical trial investigating the effect of omega-3 fatty acids on non-alcoholic fatty liver disease
Authors: G Masterton, A Shams, J Walsh, S Tuck, J Plevris, P Hayes
Journal: Gut (2015)

<h3>Introduction</h3> Non-alcoholic fatty liver disease (NAFLD) may progress to cirrhosis and end-stage liver disease. Worldwide the prevalence is increasing in line with the global obesity epidemic. To date there is no agreed pharmacological therapy for this condition. Omega-3 fatty acids have been suggested as a treatment for NAFLD. The aim of this study was to elucidate the effect of omega-3 fatty acids in patients with NAFLD in a placebo-controlled, double-blind randomised trial. <h3>Method</h3> 50 subjects with a clinical diagnosis of NAFLD were randomised to 4 grams daily of omega-3 fatty acids or placebo for six months. Subjects were reassessed three months after the end of treatment to ascertain if any changes observed had regressed. The primary endpoint of the study was change in ultrasound grade of steatosis at six months. Secondary endpoints included change in serum liver function tests (LFTs) and health-related quality of life scored by WHOQOL-BREF. <h3>Results</h3> The subjects were closely matched at baseline. In the omega-3 arm of the study 14% subjects had increased grade of steatosis whilst 18% had decreased steatosis. The remaining 68% were unchanged. In the placebo group with 16% decreased; 11% increased and 74% were unchanged. On statistical analysis, there was no significant difference between omega-3 and placebo in change in ultrasound assessment grade of the liver at 6 months compared with baseline (difference 5.5% (99% CI -22.3 – 33.3); p = 0.70). Similarly there was no significant difference between participants who received omega-3 and those who received placebo in change in secondary outcome measures i.e. grade of steatosis on ultrasound at nine months, serum liver function tests, serum lipids and health related quality of life scores at either six or nine months. <h3>Conclusion</h3> The results of this clinical trial do not support the use of omega-3 fatty acids as a treatment for NAFLD. <h3>Disclosure of interest</h3> None Declared.
Further tests for linkage of bipolar affective disorder to the tyrosine hydroxylase gene locus on chromosome 11p15 in a new series of multiplex British affective disorder pedigrees [published erratum appears in Am J Psychiatry 1997 Jan;154(1):139]
Authors: C Smyth, G Kalsi, J Brynjolfsson, J O'Neill, D Curtis, L Rifkin, E Moloney, P Murphy, R Sherrington, H Petursson, H Gurling
Journal: American Journal of Psychiatry (1996)

This study was undertaken to confirm or refute previous reports that link bipolar affective disorder to polymorphic DNA markers at or near the gene for tyrosine hydroxylase.A previous linkage analysis, which used a tetranucleotide repeat polymorphism at the tyrosine hydroxylase locus, of six Icelandic families was extended to include a new series of 17 multiply affected British families.Overall lod scores under the assumption of locus heterogeneity were between 1.20 and 1.40 at zero recombination with tyrosine hydroxylase, and these scores persisted across three affective disorder models.These results provide some support for linking affective disorder to this genetic region and suggest that additional linkage and association studies should be conducted to determine whether tyrosine hydroxylase or a nearby locus contributes to susceptibility to bipolar affective disorder in some families.
A general systems approach to severe family pathology
Authors: S Fleck
Journal: American Journal of Psychiatry (1976)

The author proposes a general systems approach to the examination and understanding of family functioning. Scrutinizing the family as an open system with 1) evolutionary goals and tangible tasks, 2) a need for "semipermeable" boundaries, 3) cultural and subcultural communication modes, 4) leadership effectiveness, and 5) the nature and age-appropriateness of the affective bonds will enable clinical judgements about family functioning that indicate general system competencies and defects. Such a framework may also lead to a typology of family process because the major functions of the family as a system (creation, nurturance, enculturation, and guidance of the young into adulthood) can be evaluated regardless of symptoms or diagnoses.
Genesis of the Ph 1 Chromosome
Authors: J. Whang-Peng, E. C. Lee, T. A. Knutsen
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Genesis of the Ph1 Chromosome Get access J. Whang-Peng, J. Whang-Peng Search for other works by this author on: Oxford Academic PubMed Google Scholar E. C. Lee, E. C. Lee Search for other works by this author on: Oxford Academic PubMed Google Scholar T. A. Knutsen T. A. Knutsen Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1035–1036, https://doi.org/10.1093/jnci/52.4.1035 Published: 01 April 1974 Article history Received: 16 January 1974 Accepted: 16 January 1974 Published: 01 April 1974