tbuckley/cabot-search huggingface dataset:
Abstract P2-09-34: ERK Phosphorylation in Fibroblasts within Breast Cancer Stroma Is Associated with an Improved Tamoxifen Response
Authors: S Busch, L Ryden, O Stål, K Jirströ, G. Landberg
Journal: Cancer Research (2010)

Abstract Background. Extra-cellular signal-regulated kinase (ERK) 1/2 is an integral part of the mitogen-activated protein kinase (MAPK) pathway, transmitting signals involved in cell proliferation and cell death upon binding of extracellular growth factors to their receptors. Whereas its role in tumour cells has been linked to key events in cell transformation, its role in tumour-associated fibroblasts, a component of the tumour stroma, is largely unknown. Material and methods. Tissue microarrays (TMAs) of two cohorts including invasive breast cancer patients were stained for ERK phosphorylation level (pERK) and SMA-alpha expression (SMAa) which were scored and analysed in regard to clinico-pathological, prognostic and molecular markers and recurrence-free survival. Results. In both clinical materials we show a significant correlation between stromal ERK phosphorylation and the marker for activated fibroblasts SMAa. SMAa expression was not linked to treatment-predictive information but instead had prognostic qualities (P=0.034, multivariate Cox regression). By analysing the unique randomised tamoxifen trial including patients receiving no adjuvant treatment we show for the first time that ERK phosphorylation in cancer-associated fibroblasts (CAF) was associated with an improved outcome upon tamoxifen treatment. In contrast, patients having ERα-positive tumours but lacking ERK phosphorylation in the stroma did not respond to tamoxifen treatment (P=0.015, multivariate interaction analyses). Discussion. This suggests that only a subpopulation of activated fibroblasts, defined by phosphorylation of ERK, is linked to a response to tamoxifen treatment illustrating the importance of the stroma for monitoring and potentially mediating treatment effects in premenopausal breast cancer. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P2-09-34.
Sudden Cardiac Death Triggered by an Earthquake
Authors: Jonathan Leor, W. Kenneth Poole, Robert A. Kloner
Journal: New England Journal of Medicine (1996)

The earthquake that struck the Los Angeles area at 4:31 a.m. on January 17, 1994, was one of the strongest earthquakes ever recorded in a major city in North America. Once the life-threatening situation was over, the Northridge earthquake, so called because its epicenter was near Northridge, California, just north of Los Angeles, provided investigators an unusual opportunity to examine the relation between emotional stress and sudden cardiac death.
S37 Vascular Endothelial Cell Growth Factor-a (vegf-a) Signalling And Neovascularisation Of Pulmonary Endarterectomy Material In Chronic Thromboembolic Pulmonary Hypertension (cteph)
Authors: M. Southwood, C. Hadinnapola, E. Moseley, D. Jenkins, M. Goddard, K. Sheares, M. Toshner, J. Pepke-Zaba
Journal: Thorax (2014)

<h3>Background</h3> Despite recent advances in the medical treatment of patients with CTEPH, relatively little is understood surrounding the underlying pathological mechanisms. Many patients have a historical documented venous thromboembolic event (VTE) and consequently, failed resolution of an acute VTE has been proposed as a key initiating factor in the subsequent development of CTEPH. Here we investigated VEGF-A levels, a key regulator of angiogenesis, in CTEPH patients prior to and following pulmonary endarterectomy (PEA) surgery to remove the thromboembolic material. We also examined the surgically excised PEA material and measured neovessel density in distal regions of the specimens. <h3>Methods and results</h3> Serum VEGF-A levels were measured by Luminex array in paired serum samples from n = 44 patients at baseline (before PEA surgery) and following PEA surgery. Following PEA surgery, serum VEGF-A levels were significantly reduced compared to baseline measurements (159.5 ± 174.8 vs. 194.4 ± 198.2, p = 0.0182). Distal regions of excised PEA material were cross sectioned and processed for histopathological examination. Neovessel density was calculated by counting the absolute number of vascular channels present within a cross-sectional area and normalised to tissue area using Image J. We also measured the time between documented VTE and subsequent PEA surgery (VTE-PEA time) in patients with a documented VTE (n = 40/44 [90%] patients), and identified an inverse correlation between neovessel density and VTE–PEA time. <h3>Conclusions</h3> Extensive angiogenesis was evident in distal PEA material from patients with CTEPH. VEGF-A is known to be a key regulator of angiogenesis and serum levels were significantly reduced following PEA surgery. Interestingly, a significant inverse correlation between neovessel density and VTE-PEA time was observed indicating that in the early stages following VTE, extensive angiogenesis is evident within the thromboembolus. Taken together these data provide further evidence that angiogenesis is an important mechanism in the attempted resolution of a VTE.
Large Left Atrial Thrombus
Authors: Kim Eagle, Bibiana Cujec, Marc Baltzan
Journal: New England Journal of Medicine (1993)

Figure 1. Large Left Atrial Thrombus. This four-chamber view of the heart (Panel A) was obtained by transesophageal echocardiography in a 75-year-old man with longstanding nonvalvular atrial fibrillation who had recently had a transient ischemic attack. A large, immobile thrombus (T in the schematic drawing in Panel B) is attached to the posterior wall of the left atrium (LA). A smaller thrombus (T) is attached to the lateral wall of the right atrium (RA). A third thrombus was present in the left atrial appendage (not shown). The large left atrial mass is unlikely to be a myxoma because of the . . .
The Role of Salt in the Fall of Blood Pressure Accompanying Reduction in Obesity
Authors: Lewis K. Dahl, Lawrence Silver, Robert W. Christie
Journal: New England Journal of Medicine (1958)

THERE is considerable evidence that the incidence of hypertension is significantly greater among obese adults than among similar nonobese persons.1 , 2 Numerous studies have been published indicating that when weight reduction is brought about in such cases a fall in the elevated blood pressure frequently follows.3 4 5 6 7 8 9 10 11 12 13 Although this extensive list suggests a remarkable agreement among observers, at least two authors have expressed doubt that a decline in weight is responsible for a decline in the high blood pressure of obese subjects.14 , 15 For some years one of us (L.K.D.) has been interested in the relation of sodium to the hypertensive process in . . .
Case 36-1991
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, P.Y. Wen, R.A. Sobel
Journal: New England Journal of Medicine (1991)

Presentation of CaseA 60-year-old man was admitted to the hospital because of progressive neurologic dysfunction and persistent elevation of the lactic dehydrogenase (LDH) level.The patient was well until 18 days earlier, when he experienced bilateral facial and head pain that was treated with pseudoephedrine and a few tablets of penicillin. The pain persisted, and about two weeks before admission he had diplopia for five minutes.Eight days before entry the patient awoke in the morning with an excruciating right periorbital and frontal headache and was taken to another hospital. General physical examination was reported to be negative, with . . .
Esophageal fully covered self-expanding metal stent for combined treatment of an aortoesophageal fistula
Authors: Eduardo Rodrigues-Pinto, Pedro Pereira, Guilherme Macedo
Journal: Endoscopy (2015)

We report on a 63-year-old man with a history of coronary artery bypass in 1995 who presented with massive hematemesis and hemodynamic instability. A computed tomography (CT) scan revealed a thoracic aortic pseudoaneurysm causing a mass effect on the esophagus ([Fig. 1]) and rupture of the aorta immediately after the origin of the left subclavian artery, with the suspicion of an aortoesophageal fistula.
Abstract 181: The combination of a novel retinoid compound with standard chemotherapy increases cytotoxicity in an ovarian cancer cell line
Authors: Jenny M. Whitworth, Patsy J. Oliver, Donald D. Muccio, J. Michael Straughn, Donald J. Buchsbaum
Journal: Cancer Research (2011)

Abstract Background: Retinoids are a class of chemotherapeutic agents that have been studied in a variety of malignancies and are known to play an important role in cellular proliferation and apoptosis. 9cUAB30 is a novel retinoid compound that has been shown to demonstrate anti-tumor activity in breast cancer and in acute promyelocytic leukemia. The objective of this study was to determine if 9cUAB30, alone and in combination with carboplatin, has cytotoxic effects on ovarian cancer cells. Methods: The ovarian cancer cell line A2780 was cultured in 96-well plates for 24 hours. Carboplatin at doses of 15 and 30 µM was added 24 hours after plating (Day 1). 9cUAB30 at doses of 0.5, 1, and 3 µM was also added at 24, 72, and 120 hours after plating (Days 1, 3 and 5). On Day 7, cell viability was assessed using adenosine triphosphate (ATP) assays. Results: Mean cytotoxic values (expressed as % of untreated control) were calculated for 9cUAB30 monotherapy. On average, 6% cytotoxicity was observed at the lowest dose (0.5 µM,) compared to 48% cytotoxicity at the medium dose (1 µM) and 66% cytotoxicity at the highest dose (3 µM). Addition of 9cUAB30 at doses of 1 and 3 µM significantly reduced cell viability (p&amp;lt;0.01) compared to controls. When used in combination with carboplatin (30 µM), 9cUAB30 at doses of 0.5, 1 and 3 µM resulted in 71%, 85% and 91% cytotoxicity, respectively. When used in combination with a lower dose of carboplatin (15 µM), 9cUAB30 at doses of 0.5, 1 and 3 µM resulted in cytotoxicity of 67%, 83% and 89%, respectively. Addition of 9cUAB30 to carboplatin at either 15 or 30 µM significantly reduced cell viability when compared to carboplatin alone (p&amp;lt;0.01). Conclusion: In previous studies of acute promyelocytic leukemia, a dose of 5 µM 9cUAB30 was commonly used for in vitro studies. In ovarian cancer, lower doses of this novel retinoid can be used to achieve significant cytotoxicity. The combination of carboplatin and 9cUAB30 provided additional ovarian cancer cellular cytotoxicity. Further in vivo studies in ovarian cancer xenografts models are underway to determine if this novel retinoid compound enhances efficacy in combination with standard chemotherapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 181. doi:10.1158/1538-7445.AM2011-181
The Effect of Adjuvant Chemotherapy on Relapse-Free Survival in Patients with Osteosarcoma of the Extremity
Authors: Michael P. Link, Allen M. Goorin, Angela W. Miser, Alexander A. Green, Charles B. Pratt, Jean B. Belasco, Jon Pritchard, James S. Malpas, Alan R. Baker, John A. Kirkpatrick, Alberto G. Ayala, Jonathan J. Shuster, Herbert T. Abelson, Joseph V. Simone, Teresa J. Vietti
Journal: New England Journal of Medicine (1986)

We conducted a randomized controlled trial to determine whether intensive multi-agent adjuvant chemotherapy improves the chances of relapse-free survival in patients with nonmetastatic high-grade osteosarcoma of the extremity, as compared with concurrent controls. After undergoing definitive surgery, 36 patients were randomly assigned to adjuvant chemotherapy or to observation without adjuvant treatment. At two years the actuarial relapse-free survival was 17 percent in the control group, similar to that found In studies before 1970, and 66 percent in the adjuvant-chemotherapy group (P<0.001). Similar results were observed among 77 additional patients who declined to undergo randomization but who elected observation or chemotherapy. We conclude that the natural history of osteosarcoma of the extremity has remained stable over the past two decades, that adjuvant chemotherapy increases the chances of relapse-free survival of patients with high-grade osteosarcoma, and that it should be given to all such patients. (N Engl J Med 1986; 314:1600–6.)
Erratum: Corrigendum: A functional variant of SUMO4, a new IκBα modifier, is associated with type 1 diabetes
Authors: D Guo, M Li, Y Zhang, P Yang, S Eckenrode, D Hopkins, W Zheng, S Purohit, R H Podolsky, A Muir, J Wang, Z Dong, T Brusko, M Atkinson, P Pozzilli, A Zeidler, L J Raffel, C O Jacob, Y Park, M Serrano-Rios, M T Martinez Larrad, Z Zhang, H-J Garchon, J-F Bach, J I Rotter, J-X She, C-Y Wang
Journal: Nature Genetics (2004)
Electric Razors as a Potential Vector for Viral Hepatitis
Authors: Colleen R. Kelly
Journal: New England Journal of Medicine (2000)

To the Editor: Viral hepatitis is an important public health threat. In the United States the prevalence of chronic hepatitis C infection is approximately 1.5 percent and that of chronic hepatitis B infection is 5.5 percent.1 The viruses that cause these infections are transmitted primarily through contaminated blood and body fluids, with the most efficient mode of transmission being direct, percutaneous exposure to blood. The rate of viral hepatitis is significantly higher among patients in the Veterans Affairs medical system than it is in the general population. As many as 24 percent of nonalcoholic patients in Veterans Affairs facilities who . . .
AB0810 Mortality among Older Adults with Hip Fractures Depending on the Method of Treatment
Authors: J.V. Averkieva, T.A. Raskina, E. Malyuta
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> To examine the effect of surgical and conservative treatment outcomes of hip fractures among older adults. <h3>Objectives</h3> The following methods of treatment were considered: medical and surgical one. Conservative treatment was presented by overlaying a derotation boot and skeletal traction, surgical one - osteosynthesis and total hip arthroplasty. <h3>Methods</h3> Information about fractures and their outcomes was obtained according to the archives of the trauma unit of city hospitals No. 2, No. 3 and No. 11 as well as logs city registry office, a telephone survey of patients and their relatives. <h3>Results</h3> In present study it was revealed that 171 patients (40.04%) got surgical treatment while 261 patients (59.96%) were treated conservatively. Among surgical treatments for patients with hip fractures osteosynthesis (36.34%) was the most commonly performed, while endoprosthesis was conducted only 3.7% of cases. Conservative treatment was mainly represented by overlaying derotation boot and skeletal traction. Mortality among patients with hip fractures, depending on the method of treatment was also traced. It was found that during the first 6 months in the surgical treatment deaths were registered with 11 (6.43%) patients and with 84 (32.18%) having a conservative treatment. Between groups of patients with hip fractures, depending on the treatment we received statistically significant differences (χ<sup>2</sup>=6,2; p&lt;0.0001). 12 months after hip fracture the mortality increased both after surgical treatment and after conservative one (12.9% i44, 81%, respectively) (χ<sup>2</sup>=6,85; p&lt;0.0001). 24 months after hip fracture mortality among patients with surgery was 25.2% (43 people), and among patients with conservative methods of treatment - 54.0% (141 people) (χ<sup>2</sup>=5,84; p&lt;0,0001). <h3>Conclusions</h3> It9s shown that in the conservative treatment of patients mortality rates were significantly higher than in the surgical treatment in all periods of observation. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5125
Breast Cancer Risk and Fatty Acids in the Breast and Abdominal Adipose Tissues
Authors: J. A. Petrek, L. C. Hudgins, B. Levine, M. Ho, J. Hirsch
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Breast Cancer Risk and Fatty Acids in the Breast and Abdominal Adipose Tissues Get access Jeanne A. Petrek, Jeanne A. Petrek Department of Surgery, Memorial Sloan-Kettering Cancer CenterNew York, N.Y Correspondence to : Jeanne A. Petrek, M.D., Memorial Sloan-Kettering Cancer Center, 1275 York Ave, New York, NY 10021. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lisa C. Hudgins, Lisa C. Hudgins Laboratory of Human Behavior and Metabolism, Rockefeller UniversityNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Barbara Levine, Barbara Levine Department of Medicine, Memorial Sloan-Kettering Cancer CenterNew York, N.Y Search for other works by this author on: Oxford Academic PubMed Google Scholar MayNah Ho, MayNah Ho Laboratory of Human Behavior and Metabolism, Rockefeller UniversityNew York Search for other works by this author on: Oxford Academic PubMed Google Scholar Jules Hirsch Jules Hirsch Laboratory of Human Behavior and Metabolism, Rockefeller UniversityNew York * See "Notes" section following "References." Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 1, 5 January 1994, Pages 53–56, https://doi.org/10.1093/jnci/86.1.53 Published: 05 January 1994 Article history Received: 25 May 1993 Revision received: 28 September 1993 Accepted: 05 October 1993 Published: 05 January 1994
Excluding NICE from early stages of value based pricing scheme was "big win for pharma," conference is told
Authors: M. Limb
Journal: BMJ (2013)

The delay to the involvement of the UK National Institute for Health and Care Excellence (NICE) in developing a new system in England for pricing drugs amounted to a “big win for pharma,” an industry expert has said.

Paul Catchpole, director of value and access for the Association of the British Pharmaceutical Industry, made his comments at the European Pharma Regulation 2013 conference in London on 13 November.

Earlier this month the industry body negotiated an extension of the voluntary Pharmaceutical Price Regulation Scheme with the government.1 This means that NHS spending on branded drugs will be held flat for the next two years, with increases of less than 2% in the following three years.

The new system of value …
Reversal of Ga-67 'Bone Scan' With Vitamin B12 Therapy in a Patient With Pernicious Anemia
Authors: KAZUYOSHI SUGA, KZUYA NISHIGAUCHI, KENSAKU SHIMIZU, HAJIME OKAZAKI, JUNICH BEKKI, NAOFUMI MATSUNAGA
Journal: Clinical Nuclear Medicine (1997)

Ga-67 citrate scintigraphy showed extensive osseous uptake in a 60-year-old man with vitamin B12 deficiency and pernicious anemia resulting from total gastrectomy. His anemia was promptly improved by B12 replacement, and follow-up Ga-67 citrate scans showed an improvement in the osseous uptake.
Twenty Years of Progress in Immunology Research Is Ready for Harvest
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Twenty Years of Progress in Immunology Research Is Ready for Harvest Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 6, 20 March 1991, Pages 388–390, https://doi.org/10.1093/jnci/83.6.388 Published: 20 March 1991
OUTCOMES FOR SURGICAL REPAIR OF KOMMERREL DIVERTICULUM AND ANEURYSM
Authors: Joseph Poterucha, Nandan Anavekar, Talha Niaz, Anushree Agarwal, Naser Ammash, Joseph Dearani, Alberto Pochettino, Carole Warnes, Heidi Connolly
Journal: Journal of the American College of Cardiology (2015)
Abstract 2020: MiR-210 modulates the hypoxic response in endothelial and ovarian cancer cells
Authors: Indira V. Subramanian, Goutam Ghosh, Hemant Joshi, Yan Zheng, Alexey Benyumov, Sundaram Ramakrishnan
Journal: Cancer Research (2010)

Abstract Tumor growth and progression is intricately linked to hypoxia induced adaptive changes. Hypoxia is known to alter chemosensitivity, upregulation of putative cancer initiating stem cells and the microenvironment. The multitude of these changes is brought about by differential gene expression. Hypoxia inducible transcription factor-1 alpha (HIF-α) is a key transducer of altered gene expression under low oxygen or ischemia. In addition to the transcriptional activation of multiple genes, hypoxia also alters miRNA levels in tumor and vascular endothelial cells. miRNAs are small noncoding RNAs ∼22 nucleotides in length representing 1%-2% of the eukaryotic transcriptome. We used microarrays to determine relative changes in 467 miRNAs in endothelial and MA148 ovarian cancer cells exposed to hypoxia. One of the miRNAs, miR-210 was significantly up-regulated under hypoxia by microarray analysis (2-fold, P &amp;lt;0.01). miR-210 expression changes were validated by RT-qPCR. Exogenous over expression of miR-210 in endothelial cells increased their proliferative capacity and induced angiogenesis. These effects were reversed by morpholino antagomiR specific for miR-210. In-vivo studies using transgenic zebrafish showed that miR-210 can increase angiogenesis which could be readily reversed by morpholino antagomiR. These studied together showed that miR-210 plays an important role in angiognenesis. We then over-expressed miR-210 in ovarian cancer cells. While in vitro growth rate was not altered, over expression of miR-210 changed the kinetics of tumor growth. Taken together, these data implicate an important role for mir-210 in hypoxia induced adaptive changes in tumor microenvironment. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2020.