tbuckley/cabot-search huggingface dataset:
AB0282 Vitamin D Status in Patients with Rheumatoid Arthritis in Egypt
Authors: R.M. Gamal, W. Gaber, S. Sayed
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Vitamin D is a regulator of calcium homeostasis.Vitamin D also plays a role in the function of the immune system.The immunomodulatory effects of vitamin D have been subject to extensive examination, leading to recent speculation that it may play a role in inflammatory diseases including rheumatoid arthritis (RA) <h3>Objectives</h3> The aim is to estimate the prevalence of vitamin D deficiency in egyptian patients with RA &amp; to analyze the association between 25-hydroxyvitamin D (25(OH)D with disease activity <h3>Methods</h3> 55 patients and 25 controls were included. Serum 25(OH)D was measured. Disease Activity Score (DAS28) and Health Assessment Questionnaire (HAQ) were assessed. Patients were divided into 4 subgroups according to activity: High (DAS28 &gt;5.1), Moderate (3.2 &lt; DAS28 ≤5.1), Low (2.6≤DAS28≤3.2) and Remission (DAS28&lt;2.60). Associations between levels of 25(OH)D and age, disease duration and activity were assessed <h3>Results</h3> 25(OH)D deficiency, insufficiency &amp; sufficiency were found in 16%,4% &amp; 80% of controls while 25(O H)D insufficiency &amp; sufficiency were found in 21.8% &amp;78.2%of RA patients with no significance difference between groups. According to DAS28 scoring, 9.1%, 7.3%, 63.6%, 20% of patients showed remission, low, moderate &amp;high disease activity consecutively. Morning stiffness, swollen joints count and 25(OH)D levels were higher in patients with moderate disease activity versus those with remission. A negative correlation was found in RA patients between 25(OH)D &amp; ESR <h3>Conclusions</h3> In Egyptian RA patient9s vitamin D deficiency is quite common, but similar to that found in control subjects; disease activity (expressed as ESR) is inversely related to 25(OH)D levels. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3744
Abstract P1-01-25: Sentinel lymph node biopsy in breast cancer: The approach in day surgery under local anaesthesia for quality-of-life and significant cost reduction
Authors: F Ricci, LG Capuano, E Saralli, P Di Legge, A Violante, A Polistena, T Scala, A Pacchiarotti, P Cannas, R Cianni, G Fanelli, P Bellardini, C De Masi
Journal: Cancer Research (2012)

Abstract Background: Sentinel lymph node biospy (SLNB) is widely used in the management of breast cancer patients without axillary metastases or inflammatory breast cancer (IBC). Methods: From Jan. 1st 2006 through Dic. 31st 2011 we performed 302 SLNB at St. M. Goretti Hospital. Mammary carcinoma was diagnosed as malignant by aspiration citology and/or biospy. In all cases with positive citology or biospy, we performed quadrantectomy and SLNB at the same time. All patients underwent pre-operative lymphoscintigraphy with intradermal pericicatritial and/or periareola injection of 12–15 MBq 99Tc colloidal albumin particles 50–80 nm size range, in 0,2 ml saline solution. We never used vital blue dye. All patients underwent surgical treatment 3–12 h. later. We performed SLNB and quadrantectomy in day surgery (DS) and local anaesthesia (LA) with 2% of Carbocaine. Axillary incision was 3–4 cm. This study was approved by an ethics committee, was discussed with all patients and informed consent was obtained. Purpose of the study is to investigate the approach in DS under LA for quality of life and significant cost reduction. Results: Six patients underwent pre-operative lymphoscintigraphy the radiotracer did not show any sentinel lymph node (SLN), in five cases we performed axillary dissection (AD). In one case of young patient who had previously been treated with chemotherapy for non-Hodgkin's lymphoma, negative positron emission tomography (PET), we performed quadrantectomy without AD. In three cases the axilla was positive. In four cases of multifocal (MF) and two of multicentric (MC) invasive breast cancer, the SLN was identified in axilla and SLNB was perfomed. SLNB in MF and MC tumors was similar to unifocal cancers. Only one case of MC cancer the SLN was positive. Six patients classified T4b according to AJCC, were treated with neoadjuvant chemotherapy (NC). The axilla was negative to ultrasound (US), PET and citology. After completion of NC, lymphatic mapping was able to identify SLN and we performed SLNB. In these patients SLN was negative. In two cases of male cancer the axilla was negative to clinical examination, in both cases SLN was positive for macrometastases. Six cases showed axillary isolated tumor cells (ITC). Eighteen micrometastases. Thirty-two macrometastases. In two case of negative SLN there was a positive second palpable lymph node. One case showed a double SLN in the axilla and internal mammary chain, only the internal mammary lymph node was positive. The SLN identification rate was 99%. After surgery we distributed a questionnaire to the patients about the acceptability of this approach. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P1-01-25.
Abstract 2300: MicroRNA-101 (miR-101) posttranscriptionally regulates the expression of EP4 receptor in colon cancers
Authors: Benjamin C. Onyeagucha, Anupama Chandramouli, Melania E. Mercado-Pimentel, Nisreen Abu Shahin, Bonnie J. LaFleur, Ronald L. Heimark, Achyut K. Bhattacharyya, Mark A. Nelson
Journal: Cancer Research (2012)

Abstract The predominant product of cyclooxygenase (COX-2) in the colon, prostaglandin (PG) E2 promotes carcinogenesis. Expression of the PGE2 receptor EP4 is upregulated during colorectal carcinogenesis. However the mechanism leading to deregulation of the EP4 receptor is not known. The present study was conducted to investigate the regulation of EP4 receptor by miRNAs. A bioinformatics search revealed a conserved target site for miR-101 within the EP4 receptor-3′ UTR. In both colorectal cancer cell lines and human specimens, we observed an inverse correlation between miR-101 and EP4 receptor protein. Transfection of LS174T cells with miR-101 significantly suppressed a luciferase reporter containing the EP4 receptor-3′-UTR. In contrast, a mutant EP4 receptor-3′-UTR was unaffected. Ectopic expression miR-101 markedly reduced cell proliferation and motility. Co-transfection of EP4 receptor could rescue colon cancer cells from the tumor suppressive effects of miR-101. Moreover, pharmacologic inhibition of EP4 receptor signaling or silencing of EP4 receptor phenocopied the effect of miR-101. This is the first study to show that the EP4 receptor is negatively regulated by miR-101. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2300. doi:1538-7445.AM2012-2300
Use of endocytoscopy in the diagnosis of a rare, depressed-type ileal adenoma
Authors: H. Shiwaku, S. Kudo, N. Ikehara, K. Ohtsuka, N. Ogata, K. Wakamura, F. Yamamura, H. Inoue, S. Hamatani
Journal: Endoscopy (2010)

An 80-year-old man was admitted to hospital with adhesive ileus, which responded to conservative management. Total colonoscopy was subsequently undertaken to investigate his symptoms. There was an incidental reddish, depressed lesion with marginal elevation, 9 mm in diameter, in the terminal ileum. Chromoendoscopic view with indigo carmine dye showed a star-shaped demarcation line in the depressed lesion ([Fig. 1]). The morphological appearance mimicked a depressed-type colorectal cancer as demonstrated by Kudo [1]. Narrow band imaging (NBI) showed a well-demarcated lesion and NBI with magnification demonstrated regularly arranged network vessels [2] ([Fig. 2]). A magnifying endoscopic view with crystal violet staining revealed small round and tubular pit patterns resembling colon cancer within the depressed lesion, instead of villi [3] ([Fig. 3]). As the patient was anticoagulated, endocytoscopy was performed for further evaluation of the lesion in order to make a decision about further management. Endocytoscopic images showed that the nuclei were fusiform and regularly arranged along the basement membrane, and the lumen was smooth and slit-like, remarkably similar to our endocytoscopic images of colonic adenoma and intramucosal neoplasia ([Fig. 4]). Furthermore, these findings were not seen in the villous mucosa of the small intestine. Therefore, the lesion was diagnosed as being either adenoma or intramucosal neoplasm of the ileum and endoscopic mucosal resection was carried out. Histopathological analysis confirmed that the lesion was a tubular adenoma with low grade atypia similar to our endocytoscopic prediction ([Fig. 5]).
SAT0345 Techniques Used to Assess Early Erosive Hand Osteoarthritis
Authors: R. Ramonda, C. Campana, P. Frallonardo, F. Oliviero, A. Scanu, S. Vio, M. Lorenzin, L. Punzi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Conventional radiology (X-rays) is still the gold standard in hand osteoarthritis (HOA), as sparse literature data seems to reflect mediocre interest in magnetic resonance (MR) imaging. <h3>Objectives</h3> Since no scoring method has been yet standardized for HOA, the Oslo HOA MR imaging score was proposed to define the disease's key features which are osteophytes, joint space narrowing (JSN), erosions, cysts, malalignment, normally assessed by plain X-rays. Other aspects such as synovitis, bone marrow edema, flexor tenosynovitis, collateral ligaments can be evaluated only by MR. In this study we enrolled patients, referring at the Clinic Rheumatology Unit, University of Padua, with hand pain and early disease onset (mean disease duration&lt;3 years)) <h3>Methods</h3> Eleven patients with early severe erosive HOA (EHOA) were studied. All patients were female, (average age 55±9.5 years; disease onset 45.4±9.48 years). HOA diagnosis was defined using American College of Rheumatology (ACR) criteria, EHOA was diagnosed in presence of proximal (PIP) or distal (DIP) interphalangeal erosions with central subcondral collapse in the same area at X-rays. All the patients underwent hand clinical examination and were evaluated with VAS, questionnaires, the grip strength test and traditional X-rays (Tab. 1). MR with contrast enhancement was performed on the dominant hand. Two radiologists used the Oslo HOA MR imaging score to assess the MR images of the 2nd-5th IP joints and the Kellgren-Lawrence (KL) score to assess the X-rays (Tab.2). The dominant hand was considered for the correlations. <h3>Results</h3> The presence of nodes correlated with KL score (r= 0.61, p=0.04), and with DIP erosion (r=0.62; p=0.038) and DIP osteophytes (r=0.69; p=0.01) by RM. Comparing clinical features and MR the tender joints correlated with DIP erosions (r=0.70; p=0.01), and with sagittal malalignment (r=0.63; p=0.03). Disease duration correlated with JSN (r=0.63, p=0.03), with DIP (r= 0.64; p=0.03) and PIP erosions (r=0.78; p=0.003), likewise VAS correlated with DIP (r=0.65; p=0.02) and PIP erosions (r=0.73; p=0.009). Comparing radiographs and MR, KL scores and bone edema showed a correlation (r=0.65; p=0.028). Considering the total number of joints scored by MR, synovitis was found in 39% (35/88), and it was more frequently detected in PIP compared to DIP joints (25/44 <i>vs</i> 10/44) similarly bone edema was more frequent in PIP vs DIP joints (12/44 and 14/44<i>vs</i>6/44 and 7/44). <h3>Image/graph</h3> <h3>Conclusions</h3> The results confirm the correlation between nodes and KL, and between tenderness and erosions by MR. MR appear to be more sensitive with respect to X-rays, as evidenced by its relationship with early symptoms (terderness). MR could therefore be employed to differentiate EHOA from the HOA and to make early diagnosis of the erosive one. <h3>Disclosure of Interest</h3> None Declared
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma
Authors: Pete A. Williams, James R. Tribble, Keating W. Pepper, Stephen D. Cross, B Paul Morgan, James E. Morgan, Simon W. M. John, Gareth R. Howell
Journal: Molecular Neurodegeneration (2016)

Glaucoma is a complex, multifactorial disease characterised by the loss of retinal ganglion cells and their axons leading to a decrease in visual function. The earliest events that damage retinal ganglion cells in glaucoma are currently unknown. Retinal ganglion cell death appears to be compartmentalised, with soma, dendrite and axon changes potentially occurring through different mechanisms. There is mounting evidence from other neurodegenerative diseases suggesting that neuronal dendrites undergo a prolonged period of atrophy, including the pruning of synapses, prior to cell loss. In addition, recent evidence has shown the role of the complement cascade in synaptic pruning in glaucoma and other diseases. Using a genetic (DBA/2J mouse) and an inducible (rat microbead) model of glaucoma we first demonstrate that there is loss of retinal ganglion cell synapses and dendrites at time points that precede axon or soma loss. We next determine the role of complement component 1 (C1) in early synaptic loss and dendritic atrophy during glaucoma. Using a genetic knockout of C1qa (D2.C1qa -/- mouse) or pharmacological inhibition of C1 (in the rat bead model) we show that inhibition of C1 is sufficient to preserve dendritic and synaptic architecture. This study further supports assessing the potential for complement-modulating therapeutics for the prevention of retinal ganglion cell degeneration in glaucoma.
A Pilot Study of Aerosolized Amiloride for the Treatment of Lung Disease in Cystic Fibrosis
Authors: Michael R. Knowles, Nina L. Church, William E. Waltner, James R. Yankaskas, Peter Gilligan, Malcolm King, Lloyd J. Edwards, Ronald W. Helms, Richard C. Boucher
Journal: New England Journal of Medicine (1990)

Excessive active absorption of sodium is a unique abnormality of the airway epithelium in patients with cystic fibrosis. This defect is associated with thickened mucus and poor clearance of airway secretions and may contribute to the pulmonary disease in these patients. To study whether the inhibition of excessive absorption of sodium might affect the course of lung disease in cystic fibrosis, we performed a double-blind, crossover trial comparing aerosolized amiloride (5 mmol per liter; 3.5 ml four times daily), a sodium-channel blocker, with vehicle alone.
FRI0401 Eosinophilic fasciitis (EF) clinical characteristics and response to mtx therapy
Authors: F. Berianu, M. D. Cohen, A. Abril, W. W. Ginsburg
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The treatment of EF is still a challenge for rheumatologists. <h3>Objectives</h3> To report our experience with fourteen EF patients on MTX followed over a period of 1 to 14 years in the rheumatology clinic. <h3>Methods</h3> Chart reviews of the patients with biopsy proven EF treated with MTX 15-20 mg/week from 1998-2012. <h3>Results</h3> There were 6 women and 8 men, aged 30 to 75 (mean age 52). None had used tryptophan. All patients had clinical induration of the arms and legs. Six had truncal involvement, seven had abdominal wall involvement and none had Raynaud’s. Eight patients had localized morphea. One patient had clinical evidence of EF involvement limited to the left side of the body but MRI showed bilateral fascial involvement of the extremities. Eleven patients were started on MTX therapy either after a trial of Prednisone or combination immunosupressive therapy. Two patients were simultaneously started on MTX and Prednisone. One patient was started on MTX alone. Three patients had been treated initially with Hydroxychloroquine/Prednisone therapy and two with Azathioprine/Prednisone without any further benefit after the partial improvement with steroids. Eleven patients were able to taper off Prednisone within 10 to 33 months (mean 16.5 months). After initiation of the MTX therapy nine patients achieved complete clinical remission within 12 months to 7 years of therapy (mean 32.3 months). Three patients maintained remission and are off all medications at 1 to 3 years of follow up. One patient is in complete clinical remission still on low dose MTX. Five patients had relapses of the disease while off MTX therapy within 7 months to 3 years (mean 24.2 months). All of relapses responded well to restarting MTX therapy and two of these patients achieved a second remission on additional MTX therapy within 18 months to 5 years. Four patients had partial remission on MTX 3-5 years after initiation of therapy. One patient had only a minimal response to MTX after 4 years of therapy. <h3>Conclusions</h3> The majority of patients (13 out of 14) had improvement on the MTX/Prednisone therapy; Eleven patients were able to taper off steroids; Nine patients achieved complete remission. We believe that MTX represents an effective treatment option for EF. <h3>References</h3> Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases. Lakhanpal S, Ginsburg WW, Michet CJ, Doyle JA, Moore SB, Semin Arthritis Rheum. 1988;17(4):221 Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients. Lebeaux D, Francès C, Barete S, Wechsler B, Dubourg O, Renoux J, Maisonobe T, Benveniste O, GatfosséM, Bourgeois P, Amoura Z, Cacoub P, Piette JC, Sène D; Rheumatology (Oxford). 2012 Mar;51(3):557-61. Epub 2011 <h3>Disclosure of Interest</h3> None Declared
Abstract 301: Ccl17 and Ccr4 co-localize in mouse lung adenomas <i>in vivo</i> and are associated with epithelial cell migration <i>in vitro</i>
Authors: Lauren Stein, Jay W. Tichelaar
Journal: Cancer Research (2012)

Abstract Lung cancer is the leading cause of cancer deaths among men and women in the United States and improved treatments are urgently needed. Like many cancers, long-term inflammation is now recognized to be a contributing factor in the progression of lung cancer from a benign to a malignant state. Exactly how inflammation contributes to lung cancer is incompletely understood. Chemokines are a group of proteins that function by attracting immune cells to areas of higher chemokine concentrations. Specific chemokine-chemokine receptor pairs control the migratory response of many inflammatory cell types. It is known that chemokines and chemokine receptors can also have direct effects on cancer cells. Using in situ hybridization, we determined that the chemokine Ccl17 and its receptor Ccr4 are coordinately induced in tumor cells in transgenic and benzo(a)pyrene-induced mouse models of lung cancer. In addition, multiple subsets of T lymphocytes within mouse lung tissue express Ccr4. Immunohistochemistry localized CCR4 to cancer cells in 11 of 32 (34%) human non-small cell lung cancer biopsies while staining was not detected in 12 non-neoplastic lung biopsies. We identified human lung cancer cell lines expressing CCR4 using flow cytometry and immunofluorescence. Treatment of human NCI-H292 lung cancer cells with CCL17 peptide induced migration in a collagen-dependent manner in a transwell migration assay. The presence of Ccr4 on both lung cancer cells and lymphocytes suggests that this receptor has multiple roles in regulating lung tumor promotion and progression. Characterization of these roles may provide novel targets to inhibit lung tumor progression. Future studies will directly address the function of Ccr4 during lung tumorigenesis in vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 301. doi:1538-7445.AM2012-301
AB0649 Clinical Features of Spontaneous Pneumomediastinum in Dermatomyositis
Authors: T. Xu, X. Zhang
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Spontaneous pneumomediastinum is a rare complication and a poor prognostic factor of dermatomyositis (DM). But the mechanisms, outcome, and prognostic factors of DM associated pneumomediastinum have not yet been evaluated. <h3>Objectives</h3> To study the clinical features and prognostic factors of spontaneous pneumomediastinum in DM. <h3>Methods</h3> A retrospective study of 301 patients with an initial diagnosis of DM was carried out, focusing mainly on patients complicated by pneumomediastinum. The clinical records including demographic variables, clinical features, laboratory data, treatment and outcomes were collected. We analyzed English published cases and combined those that were exploitable with ours for an investigation of the factors associated with poor survival. <h3>Results</h3> Among the 301 patients with DM, pneumomediastinum was observed as a complication in 8 patients, with the prevalence rate of 3.0%. Three of the patients were female, five were male, and the mean age was 48 years (range 33-67). Seven of the eight patients (87.5%) had interstitial lung disease (ILD); three patients (37.5%) had severe pulmonary infection; four patients (50%) had associated cutaneous vasculopathy. All the patients had negative anti-Jo-1 antibody, only two patients had positive ANA. Six patients (75%) had normal serum creatine kinase levels before the onset of pneumomediastinum, but eight patients (100%) had elevated lactate dehydrogenase (LDH) level. The outcome was favorable in three of these patients; five patients died within 1 month. Poor survival was associated with severe pulmonary infection (P=0.042) and elevated LDH level (more than two times of upper limit; P=0.028). <h3>Conclusions</h3> Most DM associated pneumomediastinum is accompanied by ILD. Pneumomediastinum may develop in the early course of DM; it occurs even after the improvement of muscle weakness. Death was associated with severe pulmonary infection and elevated LDH. Corticosteroids, intravenous immunogloblin and immunosuppressive therapy can result in complete resolution. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2549
Detection of a polypoid lesion inside a Meckel’s diverticulum using wireless capsule endoscopy
Authors: G. Mavrogenis, D. Coumaros, J.-P. Bellocq, J. Leroy
Journal: Endoscopy (2011)

A 24-year-old man was referred for further evaluation of obscure-occult gastrointestinal bleeding. He had presented 5 years earlier with an episode of acute iron-deficiency anemia at 9.7 g/dL without overt hemorrhage. He was treated by oral iron supplementation, but a low ferritin level persisted at 35 µg/L. He was asymptomatic and used no medication. He was twice explored unsuccessfully by gastroscopy, colonoscopy, and small-bowel follow-through.
Nephropathy in Patients with Type 2 Diabetes Mellitus
Authors: Eberhard Ritz, Stephan Reinhold Orth
Journal: New England Journal of Medicine (1999)

In the not-so-distant past, type 2 diabetes mellitus was thought to be a relatively benign condition, at least in the elderly, with relatively little effect on life expectancy or renal function.1 It has now become obvious that type 2 diabetes must be taken every bit as seriously as type 1 diabetes, in part because of its renal complications.2 However, some recent and encouraging evidence indicates that diabetic nephropathy and deterioration of renal function are to a certain extent preventable.EpidemiologyAccording to the reports of the U.S. Renal Data System,3,4 in the past two decades there has been a . . .
P1039 APPLICABILITY (APP) CRITERIA FOR REAL-TIME SHEAR WAVE ELASTOGRAPHY (RT-SWE) BY AIXPLORER COMPARED TO TRANSIENT ELASTOGRAPHY (TE) BY FIBROSCAN AND TO FIBROTEST
Authors: N. Seurat, H. Perazzo, E. Luckina, L. Royer, M. Munteanu, Y. Ngo, L. Fedchuk, O. Deckmyn, D. Monneret, F. Imbert-Bismut, V. Ratziu, T. Poynard
Journal: Journal of Hepatology (2014)