tbuckley/cabot-search huggingface dataset:
ROLE of Fecal Calprotectin as BIOMARKER of Gvhd AFTER Allogeneic STEM CELL TRANSPLANTATION
Authors: Elisabetta Metafuni, Patrizia Chiusolo, Silvia Bellesi, Sabrina Giammarco, Sara Marietti, Cecilia Zuppi, Chiara Fanali, Massimo Castagnola, Giuseppe Leone, Simona Sica
Journal: Blood (2010)
Association of adolescent and young adult cancer treatment trial activity with a national mortality reduction benefit in the United States
Authors: A. Bleyer, S. Friedman, S. Finnegan, M. Montello, T. Budd, B. Anderson, E. L. Trimble
Journal: Journal of Clinical Oncology (2009)

6605 Background: Adolescent and young adult (AYA) cancer patients in the U.S. have had less mortality and survival improvement than have children or older adults with cancer. Because &lt;3% of 20–35 year-olds are entered onto national cancer treatment trials (NCTT), in contrast to ∼50% of children, initiatives were undertaken during the past 6 years to increase NCTT AYA participation. Methods: NCTT accrual data were obtained from the Cancer Treatment Evaluation Program, NCI. Survival, mortality, and incidence data were obtained from the NCI Surveillance, Epidemiology, and End Results (SEER) program. Results: In comparison of 2002–2006 with 1996–2001, the average annual NCCT accruals of patients 15–39 years of age increased from 1,032 to 1,792, the estimated proportion of patients in this age group on NCTT increased from an average of 4.2% to 6.5%, and the proportion of all NCCT accruals (of all ages) that were in the 15–39 year age group increased from an average of 5.2% to 8.2%. Of the 11 national NCTT groups, the pediatric group (Children's Oncology Group [COG]) had the largest AYA accrual number and increase, enrolling more than twice the number of 15–39 year-olds than any other cooperative group and 1/3 of all of them. Among 15–29 year-olds nearly all of the increased accrual occurred in patients with leukemia or lymphoma, in whom the ratio of the national death rate to SEER incidence fell below the projected linear regression for this ratio in each year during 2002–2005. Conclusions: In the U.S., COG is now contributing more AYA patients to NCTT than any adult cooperative group, suggesting that the adult-treating groups and cancer centers have increased capability to increase AYA accrual and should complement the pediatric effort. That the disease group that accounted for nearly all of the increase also had a concomitant reduction in deaths relative to incidence may be cause and effect. These favorable trends should encourage implementation of the clinical trial recommendations of the NCI Program Review Group in AYA Oncology ( http://planning.cancer.gov/disease/AYAO_PRG_Report_2006_FINAL.pdf ) that are being implemented in part by the LIVESTRONG Young Adult Alliance (Closing the Gap: A Strategic Plan). [Table: see text]
TCT-274 Size And Tortuosity of A Collateral Channel Are Important Predictors of Successful Tracking in Retrograde Percutaneous Coronary Intervention (PCI) For Chronic Total Occlusion (CTO)
Authors: Ching-Chang Huang, Chi Kuo Lee, Shih-Wei Meng, Chi-Sheung Hung, Ying-Hsien Chen, Mao-Shin Lin, Chih Fan Yeh, Paul Hsien-Li Kao
Journal: Journal of the American College of Cardiology (2016)
TCT-642 Intentional Laceration of the Anterior Mitral valve leaflet to Prevent left ventricular Outflow tract ObstructioN (LAMPOON) during transcatheter mitral valve implantation: preclinical findings
Authors: Jaffar Khan, Toby Rogers, Anthony Faranesh, Adam Greenbaum, Vasilis Babaliaros, Marcus Chen, ROBERT LEDERMAN
Journal: Journal of the American College of Cardiology (2016)
Cost-effectiveness of Bariatric Surgery in Adolescents With Obesity
Authors: Matthew J. Klebanoff, Jagpreet Chhatwal, Jacob D. Nudel, Kathleen E. Corey, Lee M. Kaplan, Chin Hur
Journal: JAMA Surgery (2016)

Severe obesity affects 4% to 6% of US youth and is increasing in prevalence. Bariatric surgery for the treatment of adolescents with severe obesity is becoming more common, but data on cost-effectiveness are limited.To assess the cost-effectiveness of bariatric surgery for adolescents with obesity using recently published results from the Teen-Longitudinal Assessment of Bariatric Surgery study.A state-transition model was constructed to compare 2 strategies: no surgery and bariatric surgery. In the no surgery strategy, patients remained at their initial body mass index (calculated as weight in kilograms divided by height in meters squared) over time. In the bariatric surgery strategy, patients were subjected to risks of perioperative mortality and complications as well as initial morbidity but also experienced longer-term quality-of-life improvements associated with weight loss. Cohort demographic information-of the 228 patients included, the mean (SD) age was 17 (1.6) years, the mean (range) body mass index was 53 (34-88), and 171 (75.0%) were female-surgery-related outcomes, and base case time horizon (3 years) were based on data from the Teen-Longitudinal Assessment of Bariatric Surgery study. One-way and probabilistic sensitivity analyses were performed.Quality-adjusted life-years (QALYs), total costs (in US dollars adjusted to 2015-year values using the Consumer Price Index), and incremental cost-effectiveness ratios (ICERs). A willingness-to-pay threshold of $100 000 per QALY was used to assess cost-effectiveness.After 3 years, surgery led to a gain of 0.199 QALYs compared with no surgery at an incremental cost of $30 747, yielding an unfavorable ICER of $154 684 per QALY. When the clinical study results were extrapolated to 4 years, the ICER decreased to $114 078 per QALY and became cost-effective by 5 years with an ICER of $91 032 per QALY. Outcomes were robust in most 1-way and probabilistic sensitivity analyses.Bariatric surgery incurs substantial initial cost and morbidity. We found that surgery could be a cost-effective treatment for adolescents with severe obesity if assessed over a time horizon of 5 years. Our study underscores the need for long-term clinical trials in adolescents with at least 5 years of follow-up data that capture financial and quality-of-life end points.
TCT-236 Effects of Orbital Versus Rotational Atherectomy Facilitated PCI on the Coronary Microcirculation
Authors: Keyvan Karimi Galougahi, Navdeep Bhatti, Richard Shlofmitz, Philippe Généreux, Jeffrey Moses, Ajay Kirtane, Gregg Stone, Gary Mintz, Dimitri Karmpaliotis, Akiko Maehara, Martin Leon, Ziad Ali
Journal: Journal of the American College of Cardiology (2016)
EULAR/PReS standards and recommendations for the transitional care of young people with juvenile-onset rheumatic diseases
Authors: Helen E Foster, Kirsten Minden, Daniel Clemente, Leticia Leon, Janet E McDonagh, Sylvia Kamphuis, Karin Berggren, Philomine van Pelt, Carine Wouters, Jennifer Waite-Jones, Rachel Tattersall, Ruth Wyllie, Simon R Stones, Alberto Martini, Tamas Constantin, Susanne Schalm, Berna Fidanci, Burak Erer, Erkan Dermikaya, Seza Ozen, Loreto Carmona
Journal: Annals of the Rheumatic Diseases (2016)

To develop standards and recommendations for transitional care for young people (YP) with juvenile-onset rheumatic and musculoskeletal diseases (jRMD). The consensus process involved the following: (1) establishing an international expert panel to include patients and representatives from multidisciplinary teams in adult and paediatric rheumatology; (2) a systematic review of published models of transitional care in jRMDs, potential standards and recommendations, strategies for implementation and tools to evaluate services and outcomes; (3) setting the framework, developing the process map and generating a first draft of standards and recommendations; (4) further iteration of recommendations; (5) establishing consensus recommendations with Delphi methodology and (6) establishing standards and quality indicators. The final consensus derived 12 specific recommendations for YP with jRMD focused on transitional care. These included: high-quality, multidisciplinary care starting in early adolescence; the integral role of a transition co-ordinator; transition policies and protocols; efficient communications; transfer documentation; an open electronic-based platform to access resources; appropriate training for paediatric and adult healthcare teams; secure funding to continue treatments and services into adult rheumatology and the need for increased evidence to inform best practice. These consensus-based recommendations inform strategies to reach optimal outcomes in transitional care for YP with jRMD based on available evidence and expert opinion. They need to be implemented in the context of individual countries, healthcare systems and regulatory frameworks.
ESTUDIO DE VALIDACIÓN PARA ESTIMAR LA PROFUNDIDAD DE INSERCIÓN CON ENTEROSCOPIO DE MONOBALÓN EN UN MODELO PORCINO. CORRELACIÓN CON CÁPSULA ENDOSCÓPICA
Authors: IK Araujo Acuña, G Fernández-Esparrach, G Gómez, C Rodríguez De Miguel, C Romero, A Ginès, O Sendino, G Martínez-Palli, D Capitán, B González-Suárez
Journal: Endoscopy (2016)

Introducción: la longitud exacta de intestino delgado (ID) explorado con un enterocopio de balón y su correlación con la cápsula endoscópica (CE) es difícil de estimar. La profundidad de inserción utilizando el método de May para enteroscopia de doble balón (EDB) fue validada previamente en un modelo animal, pero no se han realizado estudios con un enteroscopio de monobalón (EMB).
Telomerase Inhibition, Telomere Shortening and Apoptotic Cell Death in Multiple Myeloma Cells Following Exposure to a Novel and Potent Telomerase Inhibitor (GRN163L), Targeting RNA component of Telomerase.
Authors: Masood A. Shammas, Hemant Koley, Alexi Protopopov, Pierfrancesco Tassone, Paola Neri, Frank Desarnaud, Allison Chin, Sergei Gryaznov, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2004)
ONE YEAR OUTCOME IN PATIENTS UNDERGOING TRANSFEMORAL AORTIC VALVE REPLACEMENT (TAVR) WITH THE REPOSITIONABLE AND RETRIEVABLE BOSTON SCIENTIFIC LOTUS VALVE COMPARED WITH THE BALLOON-EXPANDABLE EDWARDS SAPIEN 3 DEVICE
Authors: Julia Seeger, Birgid Gonska, Wolfgang Rottbauer, Jochen Woehrle
Journal: Journal of the American College of Cardiology (2017)
TCT-344 Impact of Body Mass Index on the Clinical outcomes of patients with Angiographic High-risk Coronary Artery Disease underwent Percutaneous Coronary Intervention: data from the Asan multi-vessel registry and IRISMAIN registry
Authors: Ungjeong Do, Osung Kwon, Kyusup Lee, Jung Ae Hong, JAESEOK BAE, Min Soo Cho, Cheol Hyun Lee, Do-yoon Kang, Se Hun Kang, Pil Hyung Lee, Sung-Han Yoon, Jung-Min Ahn, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2016)
GASTROYEYUNOSTOMÍA GUIADA POR ECOENDOSCOPIA (GY-USE) FRENTE A GASTROYEYUNOSTOMÍA LAPAROSCÓPICA (GY-LAP) EN EL TRATAMIENTO PALIATIVO DE LA OBSTRUCCIÓN NEOPLÁSICA AL VACIAMIENTO GÁSTRICO (OVG): ESTUDIO RETROSPECTIVO MULTICÉNTRICO
Authors: R Sánchez-Ocaña, A Tyberg, JD Poletto, I Peñas Herrero, RZ Sharaiha, R Shah, C De La Serna, E Toscano, M Kahaleh, M Pérez-Miranda
Journal: Endoscopy (2016)

Introducción: La GY-USE mediante prótesis de aposición luminal (PAL) es un nuevo procedimiento paliativo para la OVG, que todavía no ha sido comparado con la GY-Lap, considerado el tratamiento de elección en pacientes operables.
TCT-58 Long-term clinical outcomes of patients treated with everolimus-eluting bioresorbable scaffolds during daily practice – 2-year results from the ISAR-ABSORB Registry
Authors: Jens Wiebe, Petra Hoppmann, Sebastian Kufner, Salvatore Cassese, Yukinori Harada, Roisin Colleran, Erion Xhepa, Janika Repp, Simon Schneider, Tareq Ibrahim, Heribert Schunkert, Karl-Ludwig Laugwitz, Adnan Kastrati, Robert Byrne
Journal: Journal of the American College of Cardiology (2016)
DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme
Authors: Zachary D. Nagel, Gaspar J. Kitange, Shiv K. Gupta, Brian A. Joughin, Isaac A. Chaim, Patrizia Mazzucato, Douglas A. Lauffenburger, Jann N. Sarkaria, Leona D. Samson
Journal: Cancer Research (2016)

Cancer cells can resist the effects of DNA-damaging therapeutic agents via utilization of DNA repair pathways, suggesting that DNA repair capacity (DRC) measurements in cancer cells could be used to identify patients most likely to respond to treatment. However, the limitations of available technologies have so far precluded adoption of this approach in the clinic. We recently developed fluorescence-based multiplexed host cell reactivation (FM-HCR) assays to measure DRC in multiple pathways. Here we apply a mathematical model that uses DRC in multiple pathways to predict cellular resistance to killing by DNA-damaging agents. This model, developed using FM-HCR and drug sensitivity measurements in 24 human lymphoblastoid cell lines, was applied to a panel of 12 patient-derived xenograft (PDX) models of glioblastoma to predict glioblastoma response to treatment with the chemotherapeutic DNA-damaging agent temozolomide. This work showed that, in addition to changes in O6-methylguanine DNA methyltransferase (MGMT) activity, small changes in mismatch repair (MMR), nucleotide excision repair (NER), and homologous recombination (HR) capacity contributed to acquired temozolomide resistance in PDX models and led to reduced relative survival prolongation following temozolomide treatment of orthotopic mouse models in vivo Our data indicate that measuring the combined status of MMR, HR, NER, and MGMT provided a more robust prediction of temozolomide resistance than assessments of MGMT activity alone. Cancer Res; 77(1); 198-206. ©2016 AACR.
TCT-745 In-Hospital Clinical Outcomes Post Transcatheter Aortic Valve Replacement (TAVR) in Patients with History of Non-Cardiac Transplantation: Insights from the National Inpatient Sample (NIS) Database
Authors: Konstantinos Voudris, Richard Devereux, Dmitriy Feldman, Robert Minutello, Luke Kim, Rajesh Swaminathan, Harsimran Singh, Geoffrey Bergman, Arash Salemi, S. Chiu Wong
Journal: Journal of the American College of Cardiology (2016)
TCT-295 Percutaneous Coronary Intervention in Chronic Total Occlusions: A Single Center Experience on the Impact and Efficacy of Using Contemporary Techniques
Authors: Sang Yeub Lee, Nelson Bernardo, Gallino Robert A, Hector M. Garcia-Garcia, Arie Steinvil, Toby Rogers, Sarkis Kiramijyan, Edward Koifman, Smita I. Negi, Jiaxiang Gai, Rebecca Torguson, Lowell Satler, Augusto Pichard, Ron Waksman
Journal: Journal of the American College of Cardiology (2016)
Child–Parent Familial Hypercholesterolemia Screening in Primary Care
Authors: David S. Wald, Jonathan P. Bestwick, Joan K. Morris, Ken Whyte, Lucy Jenkins, Nicholas J. Wald
Journal: New England Journal of Medicine (2016)

Child-parent screening for familial hypercholesterolemia has been proposed to identify persons at high risk for inherited premature cardiovascular disease. We assessed the efficacy and feasibility of such screening in primary care practice.We obtained capillary blood samples to measure cholesterol levels and to test for familial hypercholesterolemia mutations in 10,095 children 1 to 2 years of age during routine immunization visits. Children were considered to have positive screening results for familial hypercholesterolemia if their cholesterol level was elevated and they had either a familial hypercholesterolemia mutation or a repeat elevated cholesterol level 3 months later. A parent of each child with a positive screening result for familial hypercholesterolemia was considered to have a positive screening result for familial hypercholesterolemia if he or she had the same mutation as the child or, if no mutations were identified, had the higher cholesterol level of the two parents.The use of a prespecified cholesterol cutoff value of 1.53 multiples of the median (MoM, corresponding to a percentile of 99.2) identified 28 children who had positive screening results for familial hypercholesterolemia (0.3% of the 10,095 children; 95% confidence interval [CI], 0.2 to 0.4), including 20 with a familial hypercholesterolemia mutation and 8 with a repeat cholesterol level of at least 1.53 MoM. A total of 17 children who had a cholesterol level of less than 1.53 MoM also had a familial hypercholesterolemia mutation. The overall mutation prevalence was 1 in 273 children (37 in 10,095; 95% CI, 1 in 198 to 1 in 388). The use of an initial cholesterol cutoff value of 1.35 MoM (95th percentile) plus a mutation, or two cholesterol values of at least 1.50 MoM (99th percentile), identified 40 children who had positive screening results for familial hypercholesterolemia (0.4% of the 10,095 children, including 32 children who had a familial hypercholesterolemia mutation and 8 who did not have the mutation) and 40 parents who had positive screening results for familial hypercholesterolemia.Child-parent screening was feasible in primary care practices at routine child immunization visits. For every 1000 children screened, 8 persons (4 children and 4 parents) were identified as having positive screening results for familial hypercholesterolemia and were consequently at high risk for cardiovascular disease. (Funded by the Medical Research Council.).
A Selective and Potent Rock 2 Inhibitor (KD025) Decreases Human STAT3-Dependent IL-21 and IL-17 Production and Experimental Chronic Graft-Versus-Host Disease (cGVHD)
Authors: Alexandra Zanin-Zhorov, Ryan Flynn, Leo Luznik, Angela Panoskaltsis-Mortari, Du Jing, Katelyn Goodman, Jonathan Weiss, Melanie Nyuydzefe, Wei Chen, Jonathan S Serody, Kelli PA MacDonald, Geoffrey R Hill, John O'Shea, Maria Roche, Sara Weiss, Samuel Waksal, Bruce R. Blazar
Journal: Blood (2014)
The diagnostic value of the anti-human citrullinated fibrinogen antibodies by elisa compared to anti-CCP2 antibodies, and their agreement with ACPA detected by 3 other substrates
Authors: Bert Vander Cruyssen, L Nogueira, T Cantaert, C Cavel, Lies De Rycke, M Sebag, Dieter Deforce, Dirk Elewaut, G Serre, Filip De Keyser
Journal: Annals of the Rheumatic Diseases (2006)
Analysis of operation performance of general hospitals in Shenzhen, China: a super-efficiency data envelopment analysis
Authors: Shanquan Chen, Yushan Wu, Yao Chen, Haidi Zhu, Zheng Wang, Da Feng, Zhanchun Feng, Lan Yao, Li Xiang, Eliza Lai-yi Wong, Hong Fung, Eng-kiong Yeoh, Zhiyong Liu
Journal: The Lancet (2016)
P0149 : Six-month mortality of cirrhotic patients who survived intensive care: A meta-analysis
Authors: D. Weil, V. Di Martino, E. Levesque, M. McPhail, R. Cavallazzi, E. Theocharidou, E. Cholongitas, A. Galbois, H.-C. Pan, C. Karvellas, B. Sauneuf, R. Robert, J. Fichet, G. Piton, G. Capellier, T. Thévenot
Journal: Journal of Hepatology (2015)
TCT-691 Sex-Specific Differences After Transcatheter or Surgical Aortic Valve Replacement in Intermediate Risk Patients: An Analysis from the PARTNER 2 Randomized Trial
Authors: Jonathan White, Darshan Doshi, Mathew Williams, Molly Szerlip, John Squiers, John Webb, Rebecca Hahn, Ajay Kirtane, Claire Litherland, David Cohen, E. Murat Tuzcu, Wilson Szeto, Alan Zajarias, S. Chris Malaisrie, Maria Alu, Craig Smith, Martin Leon, Michael Mack, Susheel Kodali
Journal: Journal of the American College of Cardiology (2016)
PS01.42: Predictors of Incomplete Esophageal Cancer Resection: Questionable Role of Preoperative Therapy
Authors: Mohamed Kamel, Paul C. Lee, Mohamed Rahouma, Galal Ghaly, Abu Nasar, Jeffrey L. Port, Brendon M. Stiles, Weston Andrews, Nasser K. Altorki
Journal: Journal of Thoracic Oncology (2016)
Health Care in the 2016 Election — A View through Voters’ Polarized Lenses
Authors: Robert J. Blendon, John M. Benson, Logan S. Casey
Journal: New England Journal of Medicine (2016)

This report of public opinion polls about the 2016 U.S. election contrasts the health policy views of Republican and Democratic likely voters and discusses how the outcome of the congressional and presidential elections may affect health policy.
Identification of the Novel Chimeric Gene, PVT1-WWOX, in Multiple Myeloma with 8q24 Abnormality
Authors: Hisao Nagoshi, Tomohiko Taki, Kazuhiro Nishida, Junya Kuroda, Yoshiaki Chinen, Satoru Kobayashi, Yuichi Yokokawa, Mio Yamamoto-Sugitani, Tsutomu Kobayashi, Yosuke Matsumoto, Shigeo Horiike, Masafumi Taniwaki
Journal: Blood (2012)
Hyper-alkalinization instead of hyper-hydration for the prevention of high-dose methotrexate (HDMTX) induced nephrotoxicity in osteosarcoma patients
Authors: O. Mir, J. Alexandre, P. Anract, F. Lemare, A. Babinet, E. Enkaoua, L. Guillevin, F. Goldwasser
Journal: Journal of Clinical Oncology (2005)

9059 Background: Acute tubulopathy is a severe renal toxicity of HDMTX. To prevent this risk, urine alkalinization is combined with hyper-hydration. However, early hyper-hydration rapidly decreases the plasma-to-tissue concentration gradient of methotrexate (MTX) and might reduce its antitumoral effect. We studied the renal prevention offered by hyper-alkalinization without hyper-hydration. Methods: The dose of HDMTX was 8 (3pts) or 12g/m2 (16pts), administered as a 4-hour infusion. Hypertonic 8.4% sodium bicarbonate was infused prior to HDMTX and once daily for three days. Methotrexatemia was measured at H4 (Cmax), H24, and H48 and H72. Urinary pH was measured on each miction. Creatininemia was assessed on days 1, 3 and 8. Results: Nineteen patients (7 females, 12 males) were entered. Median age: 17 years (range: 15–19). Number of cycles per patient: 16. A total of 304 cycles of HDMTX were evaluable for MTX pharmacokinetics and toxicity. Urinary pH remained constantly higher than 7.5 in all patients. The mean Cmax, H24 and H48 concentrations were 1203 μmol/l, 11.67 μmol/l and 0.43 μmol/l, respectively. In 5 cycles, reversible creatininemia elevation (< 1.5 ULN) was noticed. No episode of acute severe nephrotoxicity was observed. The main toxicity was hypokaliemia from H48. No re-hospitalisation was required. Conclusions: Hyper-alkalinization appears an efficient and reliable method to prevent the acute renal toxicity of HDMTX. No significant financial relationships to disclose.
EVALUACIÓN DE LA CALIDAD DE LA COLONOSCOPIA HABITUAL (NO DE CRIBADO) MEDIANTE INDICADORES BASADOS EN LA EXTIRPACIÓN DE ADENOMAS
Authors: A Sanchez Del Rio Garcia, JS Baudet Arteaga, M Soler, A Soler Arocha, D De Las Casas Arteaga
Journal: Endoscopy (2016)

Objetivo: Determinar la variabilidad entre endoscopistas de dos centros hospitalarios en el cumplimiento de los siguientes indicadores basados en la extirpación de adenomas en colonoscopia habitual: A.-índice de extirpación de adenomas (porcentaje de colonoscopias en los que se extirpó al menos un adenoma), B.-índice de adenomas avanzados, C.-tasa media de adenomas (número de adenomas por endoscopia), D.-tasa media de adenomas avanzados, E.-tasa media de adenomas en pacientes con adenoma y F.-tasa media de adenomas menos el primer adenoma (adenomas-1).
TCT-136 Outcomes of Hemodynamic Support with Impella in very high-risk patients undergoing Balloon Aortic Aortic Valvuloplasty: Results From the Global cVAD Registry
Authors: Pradeep Yadav, Vikas Singh, Marvin Eng, Francisco MacEdo, Guilherme Silva, Andrew Rassi, Rodrigo Mendirichaga, Carlos Alfonso, Mauricio Cohen, Igor Palacios, William O'Neill
Journal: Journal of the American College of Cardiology (2016)