tbuckley/cabot-search huggingface dataset:
Immune Cytolysis Measurement by Electrolytic Conductance: Preliminary Note
Authors: Herbert J. Rapp, Harvey R. Collen, Tibor Borsos
Journal: JNCI Journal of the National Cancer Institute (1966)

Journal Article Immune Cytolysis Measurement by Electrolytic Conductance: Preliminary Note Get access Herbert J. Rapp, Herbert J. Rapp Immunochemistry Section, Immunology Branch, National Cancer Institute4, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Harvey R. Collen, Harvey R. Collen Immunochemistry Section, Immunology Branch, National Cancer Institute4, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Tibor Borsos Tibor Borsos Immunochemistry Section, Immunology Branch, National Cancer Institute4, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 36, Issue 3, March 1966, Pages 559–563, https://doi.org/10.1093/jnci/36.3.559 Published: 01 March 1966 Article history Received: 08 December 1965 Published: 01 March 1966
THE CHEMICAL REGULATION OF RESPIRATION
Authors: H WINTERSTEIN
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Measles in France: the epidemiological impact of suboptimal immunisation coverage
Authors: I Bonmarin, D Lévy-Bruhl
Journal: Eurosurveillance (2002)

The promotion of immunisation in France since 1983 has resulted in a 97% reduction in morbidity and a reduction of 60% of mortality. However, the stable and sub-optimal coverage around 84% leads to a shift in higher age groups, where complications are more frequent and serious. The proportion of those aged over 10 years was 13% in 1985 and reached 48% in 1997, the transmission of measles being maintained in France. To eliminate the disease, vaccine coverage with 2 doses and over 95% would be necessary.
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression
Authors: Hirokazu Kimura, Katsumi Fumoto, Kensaku Shojima, Satoshi Nojima, Yoshihito Osugi, Hideo Tomihara, Hidetoshi Eguchi, Yasushi Shintani, Hiroko Endo, Masahiro Inoue, Yuichiro Doki, Meinoshin Okumura, Eiichi Morii, Akira Kikuchi
Journal: Journal of Clinical Investigation (2016)

Dickkopf1 (DKK1) is a secretory protein that antagonizes oncogenic Wnt signaling by binding to the Wnt coreceptor low-density lipoprotein receptor-related protein 6 (LRP6). DKK1 may also regulate its own signaling to promote cancer cell proliferation, but the mechanism is not understood. Here, we identified cytoskeleton-associated protein 4 (CKAP4) as a DKK1 receptor and evaluated CKAP4-mediated DKK1 signaling in cancer cell proliferation. We determined that DKK1 binds CKAP4 and LRP6 with similar affinity but interacts with these 2 receptors with different cysteine-rich domains. DKK1 induced internalization of CKAP4 in a clathrin-dependent manner, further supporting CKAP4 as a receptor for DKK1. DKK1/CKAP4 signaling activated AKT by forming a complex between the proline-rich domain of CKAP4 and the Src homology 3 domain of PI3K, resulting in proliferation of normal cells and cancer cells. Expression of DKK1 and CKAP4 was frequent in tumor lesions of human pancreatic and lung cancers, and simultaneous expression of both proteins in patient tumors was negatively correlated with prognosis and relapse-free survival. An anti-CKAP4 antibody blocked the binding of DKK1 to CKAP4, suppressed AKT activity in a human cancer cell line, and attenuated xenograft tumor formation in immunodeficient mice. Together, our results suggest that CKAP4 is a potential therapeutic target for cancers that express both DKK1 and CKAP4.
Delbert Mauritz Bergenstal 1917–1959
Authors: C HUGGINS
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Delbert Mauritz Bergenstal 1917–1959 Get access Charles Huggins Charles Huggins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 23, Issue 5, November 1959, Pages III–IV, https://doi.org/10.1093/jnci/23.5.III Published: 01 November 1959
Abstract 1665: Angiotensin II Inactivates eNOS Through Tyrosine Phosphorylation
Authors: Annemarieke E Loot, Beate Fisslthaler, Ingrid Fleming
Journal: Circulation (2008)

We recently reported that in endothelial cells, the proline-rich tyrosine kinase PYK2 is activated by fluid shear stress and phosphorylates eNOS on tyrosine 657. Tyrosine phosphorylation of eNOS in vitro completely inhibits enzyme activity and limits NO production in response to shear stress. Overexpression of PYK2 in isolated arteries abrogated NO-mediated vasodilatation. In atherosclerotic lesions, eNOS is partially inactive even in the presence of sufficient co-factors. Since PYK2 is also known to be activated by angiotensin (Ang) II and reactive oxygen species, we speculated that this mechanism plays a role in the loss of NO bioavailability in pathologies associated with increased Ang II and H 2 O 2 levels. In native porcine aortic endothelial cells and in freshly isolated murine aortae, Ang II and H 2 O 2 both enhanced the phosphorylation of eNOS on Tyr657. This effect was correlated with increased PYK2 phosphorylation and the association of PYK2 with eNOS as shown by co-immunoprecipitation. Furthermore, in vivo oxidative stress induced by endotoxins also increased p-Tyr657eNOS levels in mouse aortae. In cultured endothelial cells, H 2 O 2 had a dual effect on eNOS phosphorylation and activity. At low concentrations (1 − 100 μmol/L) H 2 O 2 stimulated the phosphorylation of Tyr657 without affecting that of either Ser1177 or Thr495. At these concentrations, H 2 O 2 also limited basal NO production and markedly impaired NO production in response to bradykinin and ionomycin. Furthermore, low (30 μmol/L) concentrations of H 2 O 2 impaired acetylcholine-induced vasodilatation in murine aorta. At higher concentrations (300–500 μmol/L) of H 2 O 2 , increased intracellular Ca 2+ elicited the phosphorylation of Ser1177 and increased NO production. Taken together, PYK2 activation under pathological conditions, i.e. increased Ang II and H 2 O 2 causes the phosphorylation of eNOS on Tyr657 impeding NO production and endothelium dependent vasodilatation. This mechanism, in addition to eNOS uncoupling, may underlie the endothelial dysfunction observed in cardiovascular diseases associated with increased activity of the renin-angiotensin system and elevated redox stress.
Histone Deacetylase SIRT1 Negatively Regulates the Differentiation of Interleukin-9-Producing CD4 + T Cells
Authors: Yu Wang, Yujing Bi, Xi Chen, Chunxiao Li, Yan Li, Zhengguo Zhang, Jian Wang, Yun Lu, Qing Yu, Huilin Su, Hui Yang, Guangwei Liu
Journal: Immunity (2016)
HG-35MET-PET DELINEATES NON-CONTRAST ENHANCING TUMOR (nCET) REGIONS AT HIGH RISK FOR RECURRENCE IN PEDIATRIC HIGH GRADE GLIOMA
Authors: John T. Lucas, Nick Serrano, Hyun Kim, Yimei Li, Alberto Broniscer, Chia-Ho Hua, Thomas Merchant, Barry Shulkin
Journal: Neuro-Oncology (2016)
Autoregulation—`A Protective Mechanism'
Authors: J W HARTSHORN, H H SHUMAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
ATPS-59IMPROVING EFFICACY OF BEVACIZUMAB TREATMENT IN GLIOBLASTOMA BY TARGETING HIF1 ALPHA
Authors: Nina Obad, Bassam Janji, Lars Prestegarden, Heidi Espedal, Mahdi Hassan, Olivier Keunen, Per Øystein Sakariassen, Morten Lund-Johansen, Simone Niclou, Rolf Bjerkvig
Journal: Neuro-Oncology (2015)

OBJECTIVE: Glioblastomas (GBM) are highly angiogenic tumors and were initially perceived as good candidates for anti -angiogenic therapy. Bevacuzimab, a monoclonal anti-VEGF antibody, was approved by the FDA in 2009 as monotherapy for recurrent GBM, but recent phase III clinical studies revealed no overall survival benefit, yet with a small improvement on progression free survival. We have recently shown in preclinical GBM models that bevacuzimab treatment increases intratumoral hypoxia with a concomitant up-regulation of HIF 1 alpha. In the present work, we show that the non-psychoactive phytocannabinoid, cannabidiol (CBD) impairs tumor growth in several pre-clinical tumor models. Moreover, we show that CBD down regulates HIF 1 alpha under hypoxic conditions and potentiates the efficacy of anti-angiogenic therapy by inhibiting specific compensatory pathways induced by hypoxia. METHODS: Patient derived GBM spheroids were cultured under hypoxic conditions and treated with CBD. The down regulation of HIF 1 alpha and several of its downstream targets was evaluated. Furthermore GBM spheroids were implanted orthopically in nude rats. The rats were treated with either bevacuzimab, CBD or in combination. Tumor growth was assessed by MR. 18F-FMISO PET was performed to assess tumor hypoxia. RESULTS/CONCLUSIONS: Our results show that CBD treatment down-regulates HIF 1 alpha under hypoxic conditions in vitro and in vivo. Combination treatment with CBD and bevacuzimab decreases tumor growth and intratumoral hypoxia in clinically relevant human GBM xenograft models. Targeting bevacuzimab induced hypoxia by inhibiting HIF 1 alpha might be a promising combinatorial treatment strategy for the treatment of GBM.
The Postconcussional Syndrome
Journal: New England Journal of Medicine (1942)

Postconcussional syndrome is characterized by somatic, cognitive and psychiatric (emotional, behavioral) symptoms that occurs after mild traumatic brain injury.It has been known that these symptoms recover fully within 3-6 months almost in 90% of patients.Although its etiology is still controversial, biological, psychological and social factors may account for the development and continuation of the symptoms.Diagnosis is based on the subjective complaints.To find out an objective method for definite diagnosis, trials searching for both neuroimaging and specific serum biomarkers stil continue.The treatment of the syndrome is mainly of palliative nature.Information, education, reassurance and multifaceted rehabilitation programmes can be beneficial.There are promising trials reporting the effectiveness of cognitive behavioral therapy in the treatment of postconcussional syndrome.Key words:
Teaching psychiatry in the health maintenance organization
Authors: D Van Buskirk, J L Feldman, S Steinberg, J M Ludden
Journal: American Journal of Psychiatry (1985)

Psychiatric residents training in a health maintenance organization (HMO) rapidly encounter the conflict between high demand for services and limited supply of time. In one HMO setting, the Harvard Community Health Plan, supervisors assist trainees in managing their practices to recognize their avoidances and conflicts and to respond therapeutically in keeping with the setting.
Anastomotic Ulcer after Somervell Operation
Authors: H. Dodd
Journal: BMJ (1947)

TEMPORAL OR GIANT-CELL ARTERITIS ERITISCf earlier age, attacks particularly the arteries of the legs and frequently results in gangrene.The disease often lasts up to a year; it seems to be selflimited, and is rarely fatal.No specific organism has been discovered to be causative, nor does drug allergy appear to play any part, a$ seems so probable in periarteritis, From
Interleukin-3: a potentially useful agent for treating chemotherapy-related thrombocytopenia.
Authors: R Hoffman
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.11.2057 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8229118 Interleukin-3: a potentially useful agent for treating chemotherapy-related thrombocytopenia. R HoffmanxR HoffmanSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.11.2057 First Page PDF © 1993 by American Society of Clinical Oncology
Some observations and questions in intensive psychotherapy
Authors: Y Fried, F Brüll
Journal: American Journal of Psychiatry (1975)

The authors discuss their observations of acute psychiatric patients in a day hospital, noting the universality of the existential concerns that arise once the patient has confronted his illness. They discuss the problem of what determins a "cure" in emotional disturbances and suggest that the primary issue is for patients to learn to live as healthy people within the limits of their individual potential.
PTK6 Inhibition Suppresses Metastases of Triple-Negative Breast Cancer via SNAIL-Dependent E-Cadherin Regulation
Authors: Koichi Ito, Sun Hee Park, Anupma Nayak, Jessica H. Byerly, Hanna Y. Irie
Journal: Cancer Research (2016)

Abstract Patients with triple-negative breast cancers (TNBC) are at high risk for recurrent or metastatic disease despite standard treatment, underscoring the need for novel therapeutic targets and strategies. Here we report that protein tyrosine kinase 6 (PTK6) is expressed in approximately 70% of TNBCs where it acts to promote survival and metastatic lung colonization. PTK6 downregulation in mesenchymal TNBC cells suppressed migration and three-dimensional culture growth, and enhanced anoikis, resistance to which is considered a prerequisite for metastasis. PTK6 downregulation restored E-cadherin levels via proteasome-dependent degradation of the E-cadherin repressor SNAIL. Beyond being functionally required in TNBC cells, kinase-active PTK6 also suppressed E-cadherin expression, promoted cell migration, and increased levels of mesenchymal markers in nontransformed MCF10A breast epithelial cells, consistent with a role in promoting an epithelial–mesenchymal transition (EMT). SNAIL downregulation and E-cadherin upregulation mediated by PTK6 inhibition induced anoikis, leading to impaired metastatic lung colonization in vivo. Finally, effects of PTK6 downregulation were phenocopied by treatment with a recently developed PTK6 kinase inhibitor, further implicating kinase activity in regulation of EMT and metastases. Our findings illustrate the clinical potential for PTK6 inhibition to improve treatment of patients with high-risk TNBC. Cancer Res; 76(15); 4406–17. ©2016 AACR.
Lesions Induced in Mice by Painting With &lt;italic&gt;p&lt;/italic&gt;-Dimethylaminobenzene-1-Azo-2-Naphthalene&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: A S MULAY, E A SAXEN
Journal: JNCI Journal of the National Cancer Institute (1953)

Lesions Induced in Mice by Painting With p-Dimethylaminobenzene-1-Azo-2-Naphthalene Get access Ambadas S. Mulay, Ambadas S. Mulay Search for other works by this author on: Oxford Academic PubMed Google Scholar Erkki A. Saxén Erkki A. Saxén National Cancer Institute4, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 5, April 1953, Pages 1259–1273, https://doi.org/10.1093/jnci/13.5.1259 Published: 01 April 1953 Article history Received: 27 October 1952 Published: 01 April 1953
Is antisocial personality a valid diagnosis among the homeless?
Authors: C S North, E M Smith, E L Spitznagel
Journal: American Journal of Psychiatry (1993)

It has been argued that among the homeless many of the features of antisocial personality may be artifacts of homelessness and that strict application of the diagnostic criteria may be insensitive to social and cultural factors in this group. The authors studied a large group of homeless men and women to investigate the appropriateness of the diagnosis of antisocial personality disorder among the homeless.Six hundred homeless men and 300 homeless women were randomly selected from shelters and street locations in St. Louis and interviewed with the National Institute of Mental Health Diagnostic Interview Schedule.In this sample of homeless men and women, most, but not all, adult symptoms of antisocial personality disorder were significantly associated with number of childhood conduct disorder symptoms. The onset of symptoms of antisocial personality disorder usually preceded the onset of homelessness. The rates of antisocial personality disorder were not significantly affected by discounting the antisocial disorder symptoms thought to be confounded with homelessness.Overall, the data support the appropriateness of the diagnosis of antisocial personality disorder among homeless populations. It cannot be said from these data that homelessness often leads to antisocial behaviors.
BRANCHIAL CYSTS AND FISTULAS
Authors: M R Himalstein
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Ostensible agency: another malpractice hazard
Authors: G J Firman
Journal: American Journal of Psychiatry (1988)

Under the tort doctrine of ostensible (apparent) agency, a psychiatrist was named as a codefendant in a psychiatric malpractice suit against a nonmedical psychotherapist employed in his medical group, who had treated the plaintiff in her private practice in the same offices. The psychiatrist was later dismissed as a defendant, but to avoid being sued in such a case, a psychiatrist contemplating an association with another professional should 1) check the professional's record with the appropriate licensing agency, 2) require proof of licensure and malpractice insurance, 3) require that the professional's private patients sign disclosure statements, and 4) assure that names on written materials are kept separate.
<i>Notes from the Field</i>: Hepatitis C Outbreak in a Dialysis Clinic — Tennessee, 2014
Authors: Daniel Muleta, Marion A. Kainer, Loretta Moore-Moravian, Andrew Wiese, Jennifer Ward, Sheila McMaster, Duc Nguyen, Joseph C. Forbi, Tonya Mixson-Hayden, Melissa Collier
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

Outbreaks of hepatitis C virus (HCV) infections can occur among hemodialysis patients when recommended infection control practices are not followed (1). On January 30, 2014, a dialysis clinic in Tennessee identified acute HCV in a patient (patient A) during routine screening and reported it to the Tennessee Department of Health. Patient A had enrolled in the dialysis clinic in March 2010 and had annually tested negative for HCV (including a last HCV test on December 19, 2012), until testing positive for HCV antibodies (anti-HCV) on December 18, 2013 (confirmed by a positive HCV nucleic acid amplification test). Patient A reported no behavioral risk factors, but did have multiple health care exposures.