tbuckley/cabot-search huggingface dataset:
Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery
Authors: Helge Thisgaard, Bo Halle, Charlotte Aaberg-Jessen, Birgitte Brinkmann Olsen, Anne Sofie Nautrup Therkelsen, Johan Hygum Dam, Niels Langkjær, Sune Munthe, Kjell Någren, Poul Flemming Høilund-Carlsen, Bjarne Winther Kristensen
Journal: Theranostics (2016)

Glioblastoma, the most common and malignant primary brain tumor, always recurs after standard treatment. Therefore, promising new therapeutic approaches are needed. Short-range Auger-electron-emitters carry the ability of causing highly damaging radiation effects in cells. The aim of this study was to test the effect of [125I]5-Iodo-2'-deoxyuridine (125I-UdR, a radioactive Auger-electron-emitting thymidine analogue) Auger-therapy on immature glioblastoma spheroid cultures and orthotopic xenografted glioblastoma-bearing rats, the latter by means of convection-enhanced delivery (CED). Moreover, we aimed to determine if the therapeutic effect could be enhanced when combining 125I-UdR therapy with the currently used first-line chemotherapeutic agent temozolomide. 125I-UdR significantly decreased glioblastoma cell viability and migration in vitro and the cell viability was further decreased by co-treatment with methotrexate and/or temozolomide. Intratumoral CED of methotrexate and 125I-UdR with and without concomitant systemic temozolomide chemotherapy significantly reduced the tumor burden in orthotopically xenografted glioblastoma-bearing nude rats. Thus, 100% (8/8) of the animals survived the entire observation period of 180 days when subjected to the combined Auger-chemotherapy while 57% (4/7) survived after the Auger-therapy alone. No animals (0/8) treated with temozolomide alone survived longer than 50 days. Blood samples and post-mortem histology showed no signs of dose-limiting adverse effects. In conclusion, the multidrug approach consisting of CED of methotrexate and 125I-UdR with concomitant systemic temozolomide was safe and very effective leading to 100% survival in an orthotopic xenograft glioblastoma model. Therefore, this therapeutic strategy may be a promising option for future glioblastoma therapy.
SAT0480 Bone Marrow Lesion in Advanced Osteoarthritis of The Knees. Correlation Study between Histopathological Findings and Structural Damage
Authors: Y. Hussein, H. Bassiouni, A. Aly
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Osteoarthritis, the most common form of arthritis, is the leading cause of mobility-related disability in elderly persons. With the aging of the population, the prevalence of osteoarthritis is increasing. Loss of hyaline articular cartilage is a central pathologic event in osteoarthritis, but the pathogenesis of cartilage loss is poorly understood. Specifically, there is a paucity of information about what factors identify joints at high risk for progression. Identification of such factors might permit better understanding of the disease process. <h3>Objectives</h3> To correlate histopathology of a bone marrow lesion (BML) pattern with severity and structural damage in osteoarthritic knees. <h3>Methods</h3> Twenty consecutive patients (age range, 59–66 years; mean, 65 years) referred for total knee replacements were examined with sagittal short inversion time inversion-recovery (STIR) and T1- and T2-weighted MRI one week prior to surgery before surgery. Different structural abnormalities on MRI were compared with those on histologic maps. <h3>Results</h3> The histopathology of BML in cases of OA revealed that 6 biopsies of cases showing bone marrow fibrosis (30%), 4 of them grade 1 (20%) and 2 of them grade 2 (10%). 18 biopsies showing cyst (90%), 9 biopsies showing abnormal trabeculae (45%), 2 of them with grade 1 (10%), 4 of them grade 2 (20%) and 3 of them grade 3 (15%). 5 biopsies showing lymphocyte (25%), 40% of them had ++CD3, while 60% of them had ++CD20. 5 biopsies showing fatty marrow (25%), 9 biopsies showing haemosidrotic marrow (45%), 6 biopsies showing blood vessels (30%), 5 of them with grade 2 (25%) and 1 with grade 3 (5%). The MRI findings of OA patients had been revealed that there were 6 patients with BML of grade 1 (30%), 10 patients of grade 2 (50%) and 4 patients of grade 3 (20%). <h3>Conclusions</h3> –BML has a strong correlation with radiographic everity measurements of osteoarthritis of the knee and pain. –In patients with knee osteoarthritis, BML in bone underneath cartilage markedly increase risk for structural progression in the knee. –Hyperemia and hematopoietic marrow were possible reasons for appearance of BML as high signal- intensity on STIR images. –BMLs are a cornerstone in progression of osteoarthritis. <h3>Acknowledgement</h3> My deepest gratitude to prof. Dr. Hassan Bassiouni, for offering me the idea of the research. I would like to thank Prof. Dr. Ibrahim Hassan for his great effort in examination of slides which is the fundamental of our study. My deepest thanks to Ass. Prof. Dr. Sami Abd El-Hakem for his cooperation and continous guidence. My deepest thanks to Ass. Prof. Dr, Abdellah Nazeer who tought me the first steps in MRI which is a fundamental brick in my work. I would like to thank Dr. Ahmed Ali Abdel Aziz for his unlimited support in reviewing the manuscript. <h3>Disclosure of Interest</h3> None declared
Heat-Shock Protein-70, -27 and Peroxiredoxin-2 Show Chaperone Function in Sickle Red Cells: Evidences from Transgenic Sickle Cell Mouse Model.
Authors: Andrea Biondani, Franco Turrini, Alessandro Matte’, Franco Carta, Alida Filippini, Yves Beuzard, Lucia De Franceschi
Journal: Blood (2007)
Allogeneic Stem Cell Transplantation in Angioimmunoblastic T-Cell Lymphoma (AITL): A Retrospective Survey from the Lymphoma Working Party (LWP) of the European Group for Blood and Marrow Transplantation (EBMT).
Authors: Charalampia Kyriakou, C. Canals, G. Taghipour, J. Finke, H. Kolb, A. Goldstone, A. Sureda, N. Schmitz
Journal: Blood (2007)
Under-prescribing of Prevention Drugs and Primary Prevention of Stroke and Transient Ischaemic Attack in UK General Practice: A Retrospective Analysis
Authors: Grace M. Turner, Melanie Calvert, Max G. Feltham, Ronan Ryan, David Fitzmaurice, K. K. Cheng, Tom Marshall
Journal: PLoS Medicine (2016)

Stroke is a leading cause of death and disability; worldwide it is estimated that 16.9 million people have a first stroke each year. Lipid-lowering, anticoagulant, and antihypertensive drugs can prevent strokes, but may be underused.We analysed anonymised electronic primary care records from a United Kingdom (UK) primary care database that covers approximately 6% of the UK population. Patients with first-ever stroke/transient ischaemic attack (TIA), ≥18 y, with diagnosis between 1 January 2009 and 31 December 2013, were included. Drugs were considered under-prescribed when lipid-lowering, anticoagulant, or antihypertensive drugs were clinically indicated but were not prescribed prior to the time of stroke or TIA. The proportions of strokes or TIAs with prevention drugs under-prescribed, when clinically indicated, were calculated. In all, 29,043 stroke/TIA patients met the inclusion criteria; 17,680 had ≥1 prevention drug clinically indicated: 16,028 had lipid-lowering drugs indicated, 3,194 anticoagulant drugs, and 7,008 antihypertensive drugs. At least one prevention drug was not prescribed when clinically indicated in 54% (9,579/17,680) of stroke/TIA patients: 49% (7,836/16,028) were not prescribed lipid-lowering drugs, 52% (1,647/3,194) were not prescribed anticoagulant drugs, and 25% (1,740/7,008) were not prescribed antihypertensive drugs. The limitations of our study are that our definition of under-prescribing of drugs for stroke/TIA prevention did not address patients' adherence to medication or medication targets, such as blood pressure levels.In our study, over half of people eligible for lipid-lowering, anticoagulant, or antihypertensive drugs were not prescribed them prior to first stroke/TIA. We estimate that approximately 12,000 first strokes could potentially be prevented annually in the UK through optimal prescribing of these drugs. Improving prescription of lipid-lowering, anticoagulant, and antihypertensive drugs is important to reduce the incidence and burden of stroke and TIA.
Acquirement of Rituximab Resistance in Lymphoma Cell Lines Is Associated with Structural Changes in the Internal Domain of CD20 Regulated at the Post-Transcriptional Level.
Authors: Myron S. Czuczman, Scott Olejniczak, Aruna C. Gowda, Petr Starostik, Francisco J. Hernandez-Ilizaliturri
Journal: Blood (2004)
Poor Outcome for Children and Adolescents with Progressive Disease or Relapse of Lymphoblastic Lymphoma - a Report of the BFM Group
Authors: Birgit Burkhardt, Alfred Reiter, Eva Landmann, Peter J. Lang, Lisa Lassay, Roswitha Dickerhoff, Max Lakomek, Guenter Henze, Arend von Stackelberg
Journal: Blood (2008)
The Alteration of SEPT5 Gene Expression in BCR-ABL Positive Cells and Its Possible Correlation with the Development and / or Progression of Chronic Myeloid Leukemia (CML)
Authors: Cintia Do Couto Mascarenhas, Anderson Ferreira Cunha, Ana Flavia Brugnerotto, Sheley Gambero, Joao Machado-Neto, Adriana S S Duarte, Katia B. Pagnano, Fernando Ferreira Costa, Carmino Antonio De Souza
Journal: Blood (2011)
Personalising exercise recommendations for brain health: considerations and future directions
Authors: Cindy K Barha, Liisa A Galea, Lindsay S Nagamatsu, Kirk I Erickson, Teresa Liu-Ambrose
Journal: British Journal of Sports Medicine (2016)

The societal value of strategies that delay the onset and progression of dementia cannot be overstated. Physical activity—unstructured and structured—is a promising, cost-effective strategy for the promotion of brain health. However, a large degree of variation exists in its efficacy. Therefore, to increase its utility as ‘medication’ for healthy cognitive ageing, it is imperative to identify key moderators and mediators of the positive effects of targeted exercise training on brain health. In this commentary, we focus on the type of targeted exercise training, the determinants of individual variation, including biological sex and genotypic factors, and the mechanisms by which exercise exerts its influence on the brain. We argue that a better understanding of these factors will allow for evidence-based, personalised, tailored exercise recommendations that go beyond the one-size-fits-all approach to successfully combat dementia.
Imatinib Long Term Effects (ILTE) Study: An International Study to Evaluate Long-Term Effects in CML Patients.
Authors: Dong-Wook Kim, Laura Antolini, François-Xavier Mahon, Francois Guilhot, Michael Deininger, Giuseppe Saglio, Arnon Nagler, Alessandro Rambaldi, Enrica Morra, Elisabetta Abruzzese, Francesco Di Raimondo, Philipp le Coutre, Rafael Hurtado Monroy, Muheez A Durosinmi, Onno Leeksma, Fabrizio Pane, Stefania Miglietta, Il-Young Kweon, Josy Reiffers, Maria Grazia Valsecchi, Carlo Gambacorti-Passerini
Journal: Blood (2009)
SAT0312 Work Disability in Patients with Systemic Lupus Erythematosus in Moldavian Lupus Study Group
Authors: M. Cebanu, V. Salaru, V. Sadovici, L. Mazur-Nicorici, M. Pasali, N. Loghin-Oprea, M. Mazur
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> As systemic lupus erythematosus (SLE) is a chronic disease, it can lead in time to important functional limitations that impair not only their quality of life but also their ability to work. Prior studies on work disability in patients with SLE have shown that about one third of the patients become disabled within 3–12 years of diagnosis <sup>1,2</sup>. <h3>Objectives</h3> To assess the work disability in patients with systemic lupus erythematosus in Moldavian lupus study group. <h3>Methods</h3> Using a cross-sectional design, patients who fulfilled the SLICC (2012) classification criteria for SLE, were recruited from rheumatology departement. Data collection included demographics, disease duration, physician-rated indices of disease activity (SLAM) and damage index (SLICC DI). Work disability was defined by patients self-report. <h3>Results</h3> The study included 106 patients (97 females, 9 males) with a mean age (±SD) of 41,1±12,6 years, mean disease duration of 90,0±87,2 months. The disease activity by SLAM was 11±5,17 points and mean SLICC/ACR DI 1,9±2,4 points. The rate of self-reported work disability among the 106 patients studied was 35,8% (38 patients). Disability rate in the first year of disease was reported by 39,5% (15) patients; after 2 to 5 years of disease the estimated rate was of 47,4% (18 patients); after 6 to 10 years of disease the estimated rate was of 10,5% (4 patients) and after 10 years of disease the self-reported work disability was 2,6% (1 patient). <h3>Conclusions</h3> The rate of work disability was 35,8% with the highest rate in the first five years of disease, affecting younger persons, which make crucial to identify strategies aimed to reduce work disability is in those patients. <h3>References</h3> Yelin E, Trupin L, Katz P, Criswell L, Rush S. Prospective study of work dynamics in SLE. Lupus 2005; 14:218. Khanna S, Pal H, Pandey RM, Handa R. The relationship between disease activity and quality of life in systemic lupus erythematosus. Rheumatology 2004; 43:1536–40. <h3>Disclosure of Interest</h3> None declared
Abstract 15264: Clinical Outcomes and Cardiovascular Responses to Exercise Training in Heart Failure Patients with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis
Authors: Gudrun Dieberg, Hashbullah Ismail, Francesco Giallauria, Neil A Smart
Journal: Circulation (2014)

Background: Exercise training induces physical adaptations for heart failure patients with systolic dysfunction but less is known about those patients with preserved ejection fraction. Objectives: To establish if exercise training produces changes in peak VO 2 and related measures, quality of life, general health and diastolic function in heart failure patients with preserved ejection fraction (HFpEF). Methods: We conducted a MEDLINE search (1985 to March 2014), for exercise based rehabilitation trials in heart failure, using search terms ‘exercise training, heart failure with preserved ejection fraction, heart failure with normal ejection fraction, peak VO 2 and diastolic heart dysfunction’. Seven intervention studies were included providing a total of 144 exercising subjects and 114 control subjects, a total of 258 participants. Results: Peak VO 2 increased by a mean difference (MD) 2.13 ml.kg -1 .min -1 (95% C.I. 1.54 to 2.71, p&lt;0.00001) in exercise training versus sedentary control, equating to a 17% improvement from baseline. The corresponding data for V E /VCO 2 slope MD 0.85 ml.kg -1 .min -1 (95% C.I. 0.05 to 1.65, p=0.04); maximum heart rate MD 5.60 bpm (95% C.I. 3.95 to 7.25, p&lt;0.00001); and 6 Minute Walk Test (6MWT) MD 32.1m (95% C.I. 17.2 to 47.1, p&lt;0.0001); diastolic function; E/A ratio MD 0.07 (95% C.I. 0.02 to 0.12, p=0.005); E/E’ ratio MD -2.31 (95% C.I. -3.44 to -1.19, p&lt;0.0001); Deceleration time (D T ) MD -13.2 msec (95% C.I. -19.8 to -6.5, p=0.0001); Minnesota Living with Heart Failure Questionnaire (MLHFQ) MD -6.50 (95% C.I. -9.47 to -3.53, p&lt;0.0001); Short Form (36) Health Survey MD 15.6 (95% C.I. 7.4 to 23.8, p=0.0002). In 3,744 hours patient-hours of training, not one death was directly attributable to exercise. Conclusions: Exercise training appears to effect several health-related improvements in people with heart failure and preserved ejection fraction.
Disruption of the mTOR-eIF4F Axis By Selectively Targeting PI3Kdelta and Proteasome Potently Inhibits Cap Dependent Translation of c-Myc in Aggressive Lymphomas
Authors: Changchun Deng, Mark Lipstein, Luigi Scotto, Yun Hao, Nicholas P. Tatonetti, Michael Mangone, Shirong Li, Suzanne Lentzsch, Ronald B. Realubit, Charles Karan, Owen A. O'Connor
Journal: Blood (2015)
Incidence and Prognosis of RTKs and RAS Mutations in CBF AML. A Retrospective Study of French Adult ALFA and Pediatric LAME Trials.
Authors: Nicolas Boissel, Hugues Leroy, Stephane De Botton, Thierry Leblanc, Nathalie Philippe, Andre Baruchel, Olivier Hermine, Herve Dombret, Claude Preudhomme
Journal: Blood (2004)
Could Hemorrhagic and Thrombotic Risk Due to Peg-Asparaginase be Identified By Coagulative Tests Using Fibtem and Antithrombin Levels? A Single Centre Study
Authors: Elena Varotto, Giovanna Sanna, Luca Spiezia, Stefania Varotto, Marta Pillon, Laura Sainati, Alessandra Todesco, Barbara Buldini, Maria Grazia Petris, Raffaella Colombatti, Manuela Tumino, Giada Biddeci, Antonio Marzollo, Maria Gabelli, Maria Paola Boaro, Elena Campello, Paolo Simioni, Giuseppe Basso, Maria Caterina Putti
Journal: Blood (2015)
Early diagnosis of ectopic pregnancy is essential to reduce deaths, says guideline
Authors: Susan Mayor
Journal: BMJ (2016)

Early diagnosis of ectopic pregnancy using transvaginal ultrasound and appropriate management depending on the type of ectopic pregnancy, including laparoscopic surgery for tubal pregnancy, is essential to reduce maternal complications and deaths from the condition, a new UK guideline recommends.1

One in every 90 pregnancies in the United Kingdom results in an ectopic pregnancy, as an estimated 11 000 ectopic pregnancies are diagnosed each year. Most occur in the fallopian tubes, but three to five in every 100 ectopic pregnancies occur at other sites, including the cervix or abdomen.

In ectopic pregnancies the embryo is unlikely to survive, and six maternal deaths …
SP0170 Time To Joint: Early Recognition and Treatment of Arthritis – The Health Professionals Perspective
Authors: P.D. Kirwan
Journal: Annals of the Rheumatic Diseases (2016)

Early recognition of inflammatory arthritis is of utmost importance, as failure to do so can delay appropriate treatment and result in permanent joint damage and disability. This presentation will set out to explore the role a Physiotherapist/Healthcare Professional can play in recognition of inflammatory joint disease. Healthcare Professionals/Physiotherapists are often the first point of contact for patients suffering from joint/musculoskeletal pain. They are therefore very well positioned to be the first to identify possible inflammatory sources of pain versus non-inflammatory sources. The question as to whether a physiotherapist can recognise inflammatory joint disease versus non-inflammatory joint conditions will be explored with the aim being to highlight the important role a physiotherapist can play in this important diagnostic challenge. With reference to ongoing clinical and research work in this field, this presentation will set out to ask whether or not a Healthcare Professional/Physiotherapist can acurately recognise/diagnose inflammatory arthritis and whether they miss inflammatory arthritis. <h3>Disclosure of Interest</h3> None declared
YM155, a Novel Survivin Suppressant, Improves the Antitumor Effect of Rituximab and Rituximab-Containing Regimens in Diffuse Large B Cell Lymphoma (DLBCL) Xenograft Mouse Models.
Authors: Mari Nakata, Takahito Nakahara, Aya Kita, Keisuke Mitsuoka, Kentaro Yamanaka, Naoki Kaneko, Sosuke Miyoshi, Masamichi Mori, Hiroshi Koutoku, Masao Sasamata
Journal: Blood (2009)
ANGI-15COMBINED TARGETING OF NOTCH AND EGFR DISPLAY ADDITIVE INHIBITORY EFFECTS ON ANGIOGENESIS AND SURVIVAL IN GLIOBLASTOMA
Authors: Mikkel Staberg, Signe Regner Michaelsen, Louise Stobbe Olsen, Mette Kjølhede Nedergaard, Camilla Bjørnbak Holst, Mette Villingshøj, Petra Hamerlik, Hans Skovgaard Poulsen
Journal: Neuro-Oncology (2015)

Glioblastoma (GBM) is a devastating tumor in adults characterized by extensive vascularization and poor survival. New treatment approaches include the targeting of angiogenesis with the hope of improving the outcome of GBM patients. In GBM, the EGFR receptor is often overexpressed or mutated and its activation was found to correlate with poor prognosis. Notch signaling is known for its role in angiogenesis during foetal development and in other cancers, but the importance of Notch signaling in GBM angiogenesis is still under investigation. GBMs often display dysregulation of the EGFR and Notch pathways and the putative crosstalk between these two pathways in regards to angiogenesis underlines their importance in gliomagenesis and therapeutic resistance. In this study, we aimed at elucidating the effect of combined targeting of both, the Notch and the EGFR signalling and its effect on angiogenesis and GBM tumor growth. In vitro experiments were performed using two patient-derived GBM cell cultures, both expressing EGFR and Notch. We demonstrated that a combined inhibition of Notch (γ-secretase inhibitor; DAPT) and EGFR (Iressa) downregulated expression of pro-survival genes (Akt and ERK), reduced expression and secretion of the angiogenic cytokine - VEGF; and displayed additive inhibition of cell viability assessed by MTT assay. Further, the abrogation of EGFR/Notch signaling in GBM cells reduced the degree of angiogenesis. Finally, DAPT and Iressa single-therapy reduced tumor-growth in vivo, however no significant benefit could be found upon combinational therapy. The present study implies that EGFR- and Notch signaling are important for GBM tumorigenesis and angiogenesis.
Molecular Characterization of Genomic Structural Alterations through CGH Arrays in Acute Myeloid Leukemia with Normal Cytogenetic Findings.
Authors: Christophe Roumier, Sandrine Geffroy, Olivier Nibourel, Sabine Quief, Celine Villenet, Aline Reneville, Valeria Biggio, Jean-Luc Laï, Jean-Pierre Kerckaert, Claude Preudhomme
Journal: Blood (2006)
Novel Multiparametric Quantitative Immunocytomorphological Characterisation of Human Bone Marrow Precursor Differentiation and of Haematopoietic Neoplasms Using ImageStream® Cytometry
Authors: Catherine Claude Martin, Chantal Jayat-Vignoles, Jean-Luc Faucher, Thaddeus George, Vidya Venkatachalam, Phil Morrissey, Jean Feuillard
Journal: Blood (2008)