tbuckley/cabot-search huggingface dataset:
GPs and paediatricians call for joint training to improve child healthcare
Authors: Adrian O’Dowd
Journal: BMJ (2016)

Two royal colleges have urged GPs and paediatricians to train together to boost their skills and help improve standards of care for children.

Interprofessional training will help clinicians, increase the quality of child care, and reduce strain on services, claimed the Royal College of Paediatrics and Child Health and the Royal College of General Practitioners in a joint position paper, published on 13 May.1

The colleges cited the success of a pilot scheme that brought together trainee GPs and paediatricians, which showed a reduction in parents taking their children to the emergency department, fewer referrals to specialist children’s services, and better adherence to national guidance.

The new report, Learning Together to Improve Child Health, detailed the Learning Together2 …
PWE-318 Emergency admission and short term outcomes in english colorectal cancer patients 1998–2010
Authors: G Hicks, E Morris, D Burke, P Finan
Journal: Gut (2015)

<h3>Introduction</h3> English colorectal cancer (CRC) outcomes are inferior to those of similar income level European countries. England has a ‘stubbornly high’ rate of emergency admission. Identifying where risk of emergency admission is greatest and outcomes of treatment poor, may help target interventions and allow the spread of best practice. <h3>Method</h3> Individuals with a first primary diagnosis of colorectal cancer treated between 1998 and 2010 within the English NHS were identified from the National Cancer Data Repository. Numbers of emergency admissions and short term outcomes (mortality at 30- and 90- days) for those undergoing major or minor resection, bypass, stoma or stent were compared. <h3>Results</h3> 353,892 individuals were identified, of which 248,655 (70.3%) presented electively and 105,237 (29.7%) presented as an emergency. The proportion of patients presenting as an emergency fell over the study period (32.6% of admissions in 1998, 25.3% in 2010), with emergency patients being more likely to be female, older (≥80years), to have colon cancer, an advanced stage of disease, more co-morbidity and to come from a socioeconomically deprived background. There was wide variation in the numbers of patients admitted as an emergency by hospital trust and in rates of early mortality. Variation in emergency admission rate did not fully account for the significant difference in post-operative mortality between hospital trusts. <h3>Conclusion</h3> Comparison of outcomes at a population level allows patterns of disease and trends in its management to be highlighted. It is well known that emergency colorectal cancer patients tend to be older, with more advanced disease, but the finding that emergencies as a proportion of CRC admissions are falling may suggest that recent efforts to reduce emergency admissions (e.g. screening) may be having an impact. The variability in emergency admission rates and rates of early mortality suggests that local factors may heavily influence outcomes, but that high performing trusts may have policies and procedures which could be of benefit to others in the management of the emergency CRC patient. <h3>Disclosure of interest</h3> None Declared.
Lipid nanoparticle delivery of a microRNA-145 inhibitor improves experimental pulmonary hypertension
Authors: Jared M McLendon, Sachindra R Joshi, Jeff Sparks, Majed Matar, Jason G Fewell, Kohtaro Abe, Masahiko Oka, Ivan F McMurtry, William T Gerthoffer
Journal: Journal of Controlled Release (2015)
Association Between Angiogenesis-Related Genes and the Response to Multimodal Therapy in High Grade Serous Advanced Ovarian Carcinoma (Aoc)
Authors: M. Mendiola, A. Redondo, J. Barriuso, V. Heredia, P. Cruz, B. Castelo Fernández, J. De Santiago, E. Diaz, M. Miguel, L. Yebenes, D. Hardisson
Journal: Annals of Oncology (2014)
Molecular Cloning and Characterization of a cDNA, CHEMR1, Encoding a Chemokine Receptor With a Homology to the Human C-C Chemokine Receptor, CCR-4
Authors: Byung-S. Youn, Sang-Ho Kim, Myung S. Lyu, Christine A. Kozak, Dennis D. Taub, Byoung S. Kwon
Journal: Blood (1997)
Effect of denial on cardiac health and psychological assessment
Authors: J E Dimsdale, T P Hackett
Journal: American Journal of Psychiatry (1982)

To determine how denial of illness affects the relationship between self-reported psychological state and cardiac status, the authors studied 204 men with heart disease. Differing degrees of denial masked the relationship between multiple-vessel coronary disease and tension, depression, or fatigue. At 1-year follow-up, denial confused the relationship between fatigue and cardiac state. Denial may augment or diminish risk; patients with high denial who did not complain of depression or tension had a higher risk for coronary disease, and patients with low denial who complained of fatigue had more morbidity at follow-up. Because of its variable effects on illness and its role in confusing the relationship between psychological state and disease, denial must be evaluated carefully.
AB0412 Clinical Meaningfulness of Radiographic Joint Damage on Physical Function, Employability and Work Productivity in Patients with Rheumatoid Arthritis: Results from the Intravenous Golimumab Study, Go-Further
Authors: C. Han, C.O. Bingham, R. Westhovens, M.E. Weinblatt, L. Kim, D. Baker, S. Peterson, E. Hsia
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To evaluate clinical meaningfulness of radiographic joint damage on physical function, employability and work productivity of patients with rheumatoid arthritis (RA). <h3>Methods</h3> GO-FURTHER was a multicenter, randomized, placebo-controlled study. Adult patients with active RA despite MTX therapy (≥6 tender and swollen joints, CRP ≥1.0 mg/dL, and RF and/or anti-CCP positive) were randomized to placebo + MTX (PBO+MTX) or GLM (2mg/kg) plus MTX at week 0, 2, and every 8 week thereafter (GLM group). Physical function was assessed using Health Assessment Questionnaire (HAQ). Employability was defined as being employed or to be able to work if job is available. Radiographic progression was measured using the van der Heijde modified total <i>Sharp score</i> (mTSS). <h3>Results</h3> At baseline, the mean (SD) mTSS was 48.5 (56.4) and 13.5% of patent had a mTSS of &gt;100. mTSS was correlated with HAQ score (r=0.23, p&lt;0.001); For patients who had mTSS&gt;100, 65.8% reported severe disability (HAQ&gt;1.5) with a mean HAQ score of 1.8, while those who had no joint damage at the baseline, 45.4% experienced severe disability with a mean HAQ of 1.2. Patients with a mTSS&gt;100 were more likely unemployable due to RA (44.2%), compared to 11.1% for those with no joint damage. The mTSS was correlated with overall impact of disease on daily productivity. The association of greater joint damage with low employability was observed even after adjusting for HAQ scores. <h3>Conclusions</h3> RA patients with physical disability accompanied with joint damage were more likely to have work disability and/or reduced daily productivity, indicating that effective RA management to prevent long-term joint damage is important to retain RA patients in the workforce. <h3>Disclosure of Interest</h3> C. Han Employee of: J&amp;J Pharmaceutical Services, LLC., C. Bingham Grant/research support from: Janssen Research &amp; Development, LLC., R. Westhovens Grant/research support from: Janssen Research &amp; Development, LLC., M. Weinblatt Grant/research support from: Janssen Research &amp; Development, LLC., L. Kim Employee of: Janssen Research &amp; Development, LLC., D. Baker Employee of: Janssen Research &amp; Development, LLC., S. Peterson Employee of: J&amp;J Pharmaceutical Services, LLC., E. Hsia Employee of: Janssen Research &amp; Development, LLC.
Effects of Feeding Heated Lard to Rats, With a Histologic Description of the Lesions Observed
Authors: Harold P. Morris, C. Donald Larsen, Stuart W. Lippincott
Journal: JNCI Journal of the National Cancer Institute (1943)

Effects of Feeding Heated Lard to Rats, With a Histologic Description of the Lesions Observed Get access Harold P. Morris, Harold P. Morris senior nutrition chemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar C. Donald Larsen, C. Donald Larsen research fellow National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Stuart W. Lippincott Stuart W. Lippincott passed assistant surgeon (R) National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 4, Issue 3, December 1943, Pages 285–303, https://doi.org/10.1093/jnci/4.3.285 Published: 01 December 1943
Detection of enterovirus D68 in patients hospitalised in three tertiary university hospitals in Germany, 2013 to 2014
Authors: Sindy Böttcher, Christiane Prifert, Benedikt Weißbrich, Ortwin Adams, Souhaib Aldabbagh, Anna Maria Eis-Hübinger, Sabine Diedrich
Journal: Eurosurveillance (2016)

Enterovirus D68 (EV-D68) has been recognised as a worldwide emerging pathogen associated with severe respiratory symptoms since 2009. We here report EV-D68 detection in hospitalised patients with acute respiratory infection admitted to three tertiary hospitals in Germany between January 2013 and December 2014. From a total of 14,838 respiratory samples obtained during the study period, 246 (1.7%) tested enterovirus-positive and, among these, 39 (15.9%) were identified as EV-D68. Infection was observed in children and teenagers (0–19 years; n=31), the majority (n=22) being under five years-old, as well as in adults &gt; 50 years of age (n=8). No significant difference in prevalence was observed between the 2013 and 2014 seasons. Phylogenetic analyses based on viral protein 1 (VP1) sequences showed co-circulation of different EV-D68 lineages in Germany. Sequence data encompassing the entire capsid region of the genome were analysed to gain information on amino acid changes possibly relevant for immunogenicity and revealed mutations in two recently described pleconaril binding sites.
A Phase I/II Open-Label Multicenter Study Of The Cyclin Kinase Inhibitor AT7519M Alone and In Combination With Bortezomib In Patients With Previously Treated Multiple Myeloma
Authors: Noopur Raje, Parameswaran N. Hari, Heather Landau, Paul G. Richardson, Jacalyn Rosenblatt, Nicole Couture, John F. Lyons, Gillian Langford, Murray Yule
Journal: Blood (2013)
Psychophysiological evidence for cerebral laterality effects in a high- risk sample of students with subsyndromal bipolar depressive disorder
Authors: R E Lenhart, E S Katkin
Journal: American Journal of Psychiatry (1986)

The authors compared bilateral recordings of electrodermal activity and conjugate lateral eye movements in two groups (10 men and 10 women each) of college students: high-risk nonpatients with subsyndromal depression and normal control subjects. Like acutely depressed patients, the high-risk subjects showed smaller right- than left-hand skin conductance response amplitudes to neutral tones. This group also showed a bias toward left-tending conjugate lateral eye movements in response to various cognitive problems. Control subjects showed symmetrical responses on all electrodermal activity measures and question-specific conjugate lateral eye movements. These data are tentatively interpreted as reflecting right-hemisphere hyperexcitability in affective illness.
CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia
Authors: Lukasz Przybyl, Nadine Haase, Michaela Golic, Julianna Rugor, Maria Emilia Solano, Petra Clara Arck, Martin Gauster, Berthold Huppertz, Christoph Emontzpohl, Christian Stoppe, Jürgen Bernhagen, Lin Leng, Richard Bucala, Herbert Schulz, Arnd Heuser, M. Susanne Weedon-Fekjær, Guro M. Johnsen, Dirk Peetz, Friedrich C. Luft, Anne Cathrine Staff, Dominik N. Müller, Ralf Dechend, Florian Herse
Journal: Circulation Research (2016)

We hypothesized that cluster of differentiation 74 (CD74) downregulation on placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia.Preeclamptic pregnancies feature hypertension, proteinuria, and placental anomalies. Feto-placental macrophages regulate villous trophoblast differentiation during placental development. Disturbance of this well-balanced regulation can lead to pathological pregnancies.We performed whole-genome expression analysis of placental tissue. CD74 was one of the most downregulated genes in placentas from preeclamptic women. By reverse transcriptase-polymerase chain reaction, we confirmed this finding in early-onset (<34 gestational week, n=26) and late-onset (≥34 gestational week, n=24) samples from preeclamptic women, compared with healthy pregnant controls (n=28). CD74 protein levels were analyzed by Western blot and flow cytometry. We identified placental macrophages to express CD74 by immunofluorescence, flow cytometry, and RT-PCR. CD74-positive macrophages were significantly reduced in preeclamptic placentas compared with controls. CD74-silenced macrophages showed that the adhesion molecules ALCAM, ICAM4, and Syndecan-2, as well as macrophage adhesion to trophoblasts were diminished. Naive and activated macrophages lacking CD74 showed a shift toward a proinflammatory signature with an increased secretion of tumor necrosis factor-α, chemokine (C-C motif) ligand 5, and monocyte chemotactic protein-1, when cocultured with trophoblasts compared with control macrophages. Trophoblasts stimulated by these factors express more CYP2J2, sFlt1, TNFα, and IL-8. CD74-knockout mice showed disturbed placental morphology, reduced junctional zone, smaller placentas, and impaired spiral artery remodeling with fetal growth restriction.CD74 downregulation in placental macrophages is present in preeclampsia. CD74 downregulation leads to altered macrophage activation toward a proinflammatory signature and a disturbed crosstalk with trophoblasts.
PRELIMINARY REPORT ON THE PRESENCE OF A "FILTER PASSING" VIRUS IN CERTAIN DISEASES: With Especial Reference to Trench Fever, Influenza, and Nephritis
Authors: J. R. Bradford, E. F. Bashford, J. A. Wilson
Journal: BMJ (1919)

Sitch in outlinle is the lJistory of tlhis remf.arkcableeffort, 41 e resuilts of -which a(gree with those obtained elsewlhere in.Egypt.Whleni Lieut.-ColonelElgood ilntroduced pro- pillaxis lhe did not in any way relax any of the otlher luecaltions.Gen7en(, Conclulsion1s.'rlTe lesson taualgt by tlte expelieus ce in Egypt is that all e epressive mneasures.all tlle constructive social measures, all the educational efforts anid all the emotional alpeals result in onlv a liml-ited amnount of success and (Illv reduce veniereal diseases to a moderate extent.It is evident that a very larae -number of miien either find the sexual appetite overpowering or dleliberately indulge, an(I naless some formi of p)roplhylaxis is adopted many infee- tioits are cer'tain.Soie of the men were quite candlid and stated they intended to indutlge, despite generals, doctors.und chaplains.and wvitlh or witlhout proplhylaxis, thoughi they pieferred to be safe.The conclusions reached by ime wvere that primary propyhlylxis and ablution tents are botlh quite effective iii preventing infection.The objections raised by some lep)le to primlary p)rophylaxis are botlh mnoral and medical.lThe imoralists say that the free use of primnary pllhylaxis would indul-lce people to becom-le miore iummoral.ami iuniable to follow this line of reasoninug.The -use Of pr-oplhylactics at tlhe timne of exposure, say 9.30 p.m.. cannlot prodice a very differenit moraitl result froin tiJe use of .pVo0lhylactit;shlalf an h1onr later in the ablution tent.
Inhaled Nitric Oxide Use in the Neonatal Intensive Care Unit
Authors: William A. Carey, Marc A. Ellsworth, Malinda N. Harris
Journal: JAMA Pediatrics (2016)

This Viewpoint recommends that the research model for the Children's Oncology Group be emulated to study the effects of inhaled nitric oxide in neonates to establish acceptable practice patterns and lower the economic burden on the US health care system.
Tocainide
Authors: Dan M. Roden, Raymond L. Woosley
Journal: New England Journal of Medicine (1986)

MANY new antiarrhythmic agents have recently become available in the United States. One of these, an oral form of the lidocaine analogue tocainide (Tonocard, Merck Sharpe and Dohme), was first marketed in November 1984 for use in the suppression of symptomatic ventricular arrhythmias. It is important to recognize that although asymptomatic ventricular ectopic beats may indicate an increased susceptibility to sudden cardiac death in some patients, no currently available data suggest that therapy with antiarrhythmic drugs prevents this outcome.Lidocaine continues to be the drug of choice for the short-term management of serious ventricular arrhythmias. However, long-term oral therapy with . . .
New contract will “strengthen morale” of junior doctors, says health secretary
Authors: Zosia Kmietowicz
Journal: BMJ (2016)

England’s health secretary, Jeremy Hunt, has said that the “historic agreement” on the new contract for junior doctors will allow the government to deliver a seven day NHS, improve the safety of patients, increase NHS productivity, and “strengthen morale and quality of life of junior doctors.”

Speaking in the House of Common on Thursday 19 May, Hunt said, “The new contract meets all the government’s red lines for delivering a seven day NHS and remains within the existing pay envelope.”

He was speaking the day after the arbitration body Acas (the Advisory, Conciliation and Arbitration Service) announced that an agreement had been reached on a new contract for junior doctors in England, after 10 days of …
Abstract A37: Aberrant DNA methylation of HTATIP2 and UCH-L1 as prognostic and predictive biomarkers for cholangiocarcinoma
Authors: Temduang Limpaiboon, Chaiyachet Nanok, Siriporn Proungvitaya, Patcharee Jearanaikoon, Ake Pugkhem, Anucha Puapairoj
Journal: Cancer Research (2016)

Abstract Cholangiocarcinoma (CCA) is a malignancy of bile duct epithelial cell lining. In the past decade, the incidence and mortality rates of CCA have been increasing worldwide. The effective treatment modality for CCA is surgical resection. Adjuvant chemotherapy and/or radiotherapy are optional therapy for unresectable and postoperative CCA. Unfortunately, the responsiveness of CCA patients to chemotherapy was relatively low and 5-year survival rate was poor. We have analyzed data which were obtained from our previous study on methylation microarray based on chemotherapeutic drug resistance and found aberrant DNA methylation of genes related to chemotherapy. This present study aimed to quantitate DNA methylation levels of 10 candidate genes related to chemotherapy in 54 CCA and 19 normal adjacent tissues using methylation-sensitive high resolution melting (MS-HRM) analysis. The methylation level of each gene was statistically analyzed with clinical parameters. Genes with high methylation level were UCH-L1 and IRF4, and genes with moderate methylation were CCND2, HTATIP2 and TP53I3. We found significant difference in methylation levels of HTATIP2 (P=0.036) and UCH-L1 (P=0.012) between short and long survival groups. Patients with high methylation level of HTATIP2 and low methylation of UCH-L1 showed longer overall survival (P=0.03 and P=0.044, respectively). Interestingly, chemotherapeutic responders showed higher methylation level of HTATIP2 than non-responders (P=0.020), whereas no significant difference in UCH-L1 methylation level was observed between these two groups. The methylation levels of HTATIP2 and UCH-L1 were low in normal adjacent tissues. In patients who received chemotherapy, patients who had high methylation of HTATIP2 and low methylation of UCH-L1 showed longer overall survival (P&amp;lt;0.001 and P=0.041, respectively). Moreover, HTATIP2 methylation was associated with tumor progression in which lower methylation level was found in CCA patients with positive lymph node metastasis (P=0.029). In conclusion, our finding indicates the great value of DNA methylation levels of HTATIP2 and UCH-L1 as prognostic and predictive markers for CCA patients. Citation Format: Temduang Limpaiboon, Chaiyachet Nanok, Siriporn Proungvitaya, Patcharee Jearanaikoon, Ake Pugkhem, Anucha Puapairoj. Aberrant DNA methylation of HTATIP2 and UCH-L1 as prognostic and predictive biomarkers for cholangiocarcinoma. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr A37.
Features of changes of system and local level of nitric oxide metabolitesand concentration of soluble molecules of major histocompatibility complex class i at patients with anexacerbation of COPD
Authors: Svetlana Soodaeva, Nailya Kubysheva, Igor Klimanov, Timur Li, Larisa Postnikova, Kubat Rahatbek, Victor Novikov, Ann Zhogota
Journal: European Respiratory Journal (2014)

Objective: To investigate the contents of nitric oxide metabolites and the concentration of soluble molecules of major histocompatibility complex class I (sHLA-I) in various biological liquids of patients with exacerbation of COPD.  We examined 96 patients of 44-69 years old (63 +/-4,8) with COPD stage II (n = 47) and III (n = 49), and 30 healthy non-smokers.  It was found that the progressive increase of the NO 2  -  level in the blood was linked to the higher degree of COPD. The content of NO 2-  metabolites found in patients with COPD stage II exceeded the control group average by 1.35 times (3,8+/-0,3 µM, p=0,036) and in patients with the disease at stage III by 2.1 times (5,87+/-0,77 µM, p=0,006). The results showed there was an increase in total concentrationof ΣNO 3  - /NO 2  -  in an exhaled breath condensate (EBC) in patients with COPD compared to the control group (5,57+/-1,1 µM). The serum content of sHLA-I was also increased in patients with a severe degree of disease compared to the healthy non-smoking volunteers. For the patients with stages II and III of COPD it was established that they had a progressively increasing level of sHLA-I molecules in both EBC and induced sputum compared to the control group. There was also a positive correlation between the concentration ofΣNO 3  - /NO 2  -  in EBC and the level of sHLA-I in serum (r=0,8 p=0,001) and in EBC (r=0,57 p=0,032).  The discovered relationships demonstrate that nitric oxide metabolites can modify the process of antigen presentation in patients with COPD which can be one of the reasons for an exacerbation of this disease.
Where Do We Go from Here?
Authors: John Lister
Journal: New England Journal of Medicine (1977)

The upgrading of district and regional hospitals was one of the outstanding achievements of the earlier years of the National Health Services (N.H.S.); the establishment of postgraduate medical centers in these hospitals has been one of the most interesting and worthwhile developments in the last 15 years. Having accepted an invitation to open such a center at a hospital in the South of England, I was asked for the title of my talk and rather hastily said that I would try to answer the question, "Where do we go from here?"Perhaps the question came to my mind because the . . .