tbuckley/cabot-search huggingface dataset:
Multiple Strictures in Jejunal Crohn9s Disease: Push Enteroscopy Dilation
Authors: E Pérez-Cuadrado, E Molina Pérez
Journal: Endoscopy (2001)

Therapeutic push enteroscopy (TPE) is useful when bleeding from small bowel lesions occurs and endoscopic access is difficult. We have reported previously that push enteroscopy is useful in diagnosis of Crohn9s disease (CD) without macroscopic lesions in the colon and upper digestive tract, because macroscopic and microscopic findings [1]. Complications in the proximal small bowel are rare, but in some cases surgery in duodenal and jejunal stenosis requires intestinal derivation and changes in their medical approach. Endoscopic dilation of stenosis in CD is a good treatment in the colon and upper digestive tract. We report an alternative technique by TPE in the jejunum.
Altered Development and Cytokine Responses of Myeloid Progenitors in the Absence of Transcription Factor, Interferon Consensus Sequence Binding Protein
Authors: Marina Scheller, John Foerster, Clare M. Heyworth, Jeffrey F. Waring, Jürgen Löhler, Gary L. Gilmore, Richard K. Shadduck, T. Mike Dexter, Ivan Horak
Journal: Blood (1999)
Multiple Myeloma
Authors: H S Andersen, J H Godwin
Journal: New England Journal of Medicine (1996)

Figure 1. A 73-year-old man presented with a two-week history of nausea, anorexia, weight loss, and fatigue. He had progressive renal failure, with marked proteinuria (protein excretion, 3.5 g per 24 hours) despite a finding of 1+ proteinuria on dipstick examination. Urine protein electrophoresis revealed lambda light chains. A bone marrow aspirate was obtained, and a diagnosis of multiple myeloma was confirmed by the finding of a bone marrow infiltrate of plasma cells with morphologic atypia (Panel A: Wright–Giemsa, ×370; Panel B: Wright–Giemsa, ×730).
AN ANTIBODY THAT INHIBITS IN VITRO BONE MARROW PROLIFERATION IN A PATIENT WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND APLASTIC ANEMIA
Authors: F. Amos Bailey, Michael Lilly, Luigi F. Bertoli, Gene V. Ball
Journal: Arthritis & Rheumatology (1989)

A non-complement-dependent antibody that inhibits bone marrow proliferation in vitro was detected in the serum of a patient with systemic lupus erythematosus and aplastic anemia. The patient recovered from the aplastic anemia following treatment with corticosteroids and plasmapheresis. The antibody could no longer be detected after this recovery. This case demonstrates that a rare, but potentially lethal, complication of systemic lupus erythematosus is aplastic anemia due to an autoantibody. Results of the experiments suggest a mechanism for, and treatment of, similar cases.
OP0263 CCL19 and CCL21 Chemokines Enhance Osteoclast Migration and Resorption Activity
Authors: J. Lee, H.-H. Kim
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Bone resorption is a severe problem associated with inflammatory disease like periodontitis and rheumatoid arthritis. Osteoclasts, cells responsible for bone resorption, have been shown to be affected by some cytokines and chemokines. However, whether CCL19 and CCL21 chemokines have any role in the regulation of osteoclast differentiation or activation has not yet been investigated. <h3>Objectives</h3> The purpose of this study was to examine the potential role of CCL19 and CCL21 chemokines and their recepor CCR7 in the differentiation and/or activation of osteoclasts. <h3>Methods</h3> To evaluate the mRNA expression levels of CCL19 and CCL21 and their receptor CCR7 in rheumatoid arthritis and osteoarthritis patients, the microarray results deposited to gene expression omnibus were retrieved and analyzed. The expression levels of these molecules and differentiation markers in osteoclasts were measured by real time polymerase chain reaction, western blotting or flow cytometry. Cell migration was quantified by a transwell assay. Resorption activity was performed on the calcium phosphate-coated dish or dentin slice and analyzed by von Kossa staining or confocal microscopy. Collagen transplantation model was used to examine the in vivo effects of these cytokines. <h3>Results</h3> The expression levels of CCL19, CCL21 and CCR7 were higher in rheumatoid arthritis than in osteoarthritis patients. Bone marrow macrophages and osteoclasts expressed more CCR7 in response to inflammatory stimuli TNFalpha, IL-1beta and LPS. CCL19 and CCL21 promoted the migration of both bone marrow macrophages and osteoclasts and resorption activity of osteoclasts. CCL19 and CCL21 activated Rho and its downstream ROCK via CCR7. CCR7 siRNA and ROCK inhibition negated the effects of CCL19 and CCL21. Administration of CCL19 and CCL21 onto calvarial bones of mice in the collagen transplantation model showed that these cytokines can promote the bone resorption in vivo. <h3>Conclusions</h3> This study demonstrates that CCL19 and CCL21 chemokines increase osteoclast migration and resorption activity via CCR7 and intracellular Rho-ROCK signaling. As these chemokines present at a high level in rheumatoid arthritis patients, CCL19 and CCL21 may play important roles in bone destruction associated with rheumatoid arthritis. <h3>Disclosure of Interest</h3> None declared
Chronic Inflammatory Bowel Disease.
Authors: J R Madsen, L S Laursen, K Lauritsen
Journal: Annals of Internal Medicine (1975)

Chronic inflammatory bowel disease (IBD) encompasses the disease entities, ulcerative colitis (UC) and Crohn's disease (CD). An aetiologic agent has not yet been defined and the diagnosis is based, therefore, on the sum of clinical, paraclinical, radiologic, endoscopic and histopathologic features. In recent years pathogenetic studies have focused on immune mechanisms, transmissible infectious agents, the potential role of the normal intestinal flora, dietary factors, enzymatic alterations and genetic features, in addition to vascular, neuromotor, allergic and psychologic factors. The corner stones in medical therapy of IBD are still corticosteroids and sulphasalazine (SAZ). The new oral salicylates, which are analogues of SAZ or "slow release" preparations of 5-aminosalicylic acid (mesalazine), have provided a therapeutic progress, because they are tolerated better than SAZ. Immunosuppressive agents, such as azathioprine and 6-mercaptopurine, reduce the requirement for corticosteroids and are effective in refractory CD, but the effect is delayed up to several months. The therapeutic action of cyclosporine A is not sustained, but often associated with side effects. Metronidazole has a beneficial effect on perineal disease. The efficacy of antimycobacterial drugs, sodium-cromoglycate, lidocaine, clonidine and sucralfate has been reported only in optimistic case stories and small open trials. A diet, rich in omega-3-fatty acids, modifies leukotriene (LT) production, but its clinical efficacy is insufficient. The first anti-leukotriene-drug, zileuton, has recently been evaluated and a significant, although insufficient, clinical response was obtained by a 70 per cent inhibition of rectal LTB4 synthesis. Dietary therapy may be useful as an adjunct to treatment of local complications in CD.(ABSTRACT TRUNCATED AT 250 WORDS)
Use of the Esophagoscope for Obtaining Biopsies of Gastric Tumors&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Cecil O. Patterson, M. D., F. A. C. P.
Journal: JNCI Journal of the National Cancer Institute (1949)

Use of the Esophagoscope for Obtaining Biopsies of Gastric Tumors Get access Cecil O. Patterson, M. D., F. A. C. P. Cecil O. Patterson, M. D., F. A. C. P. Department of Medicine, Southwestern Medical College, and the Gastroenterology Clinics at Parkland and Baylor University Hospitals, Dallas, Texas Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 477–479, https://doi.org/10.1093/jnci/10.2.477 Published: 01 October 1949
Karyotypic Complexity In Acute Myeloid Leukemia In The Context Of Adverse Prognosis
Authors: Friedrich Stölzel, Brigitte Mohr, Michael Kramer, Christoph Röllig, Tilmann Bochtler, Alwin Krämer, Uta Oelschlägel, Jan Moritz Middeke, Uwe Platzbecker, Markus Schaich, Johannes Schetelig, Gerhard Ehninger, Martin Bornhäuser
Journal: Blood (2013)
Measures to improve microbial quality surveillance of gastrointestinal endoscopes
Authors: Philippe Saliou, Hervé Le Bars, Christopher Payan, Valérie Narbonne, Franck Cholet, Julien Jézéquel, Virginie Scotet, Michel Robaszkiewicz, Divi Cornec, Geneviève Héry-Arnaud, Raoul Baron
Journal: Endoscopy (2016)

Infectious outbreaks associated with the use of gastrointestinal endoscopes have increased in line with the spread of highly resistant bacteria. The aim of this study was to determine the measures required to improve microbial quality surveillance of gastrointestinal endoscopes.We reviewed the results of all microbiological surveillance testing of gastrointestinal endoscopes and automatic endoscope reprocessors (AERs) performed at Brest Teaching Hospital from 1 January 2008 to 1 June 2015. We analyzed the influence of the time of incubation on the rate of positive results using the Kaplan - Meier method. We also studied risk factors for gastrointestinal endoscope contamination using a multivariable logistic regression model.Over the study period, 1100 microbiological tests of gastrointestinal endoscopes (n = 762) and AERs (n = 338) were performed. A total of 264 endoscope tests (34.6 %) showed a level of contamination higher than the target. After 2 days of incubation, contamination was apparent in only 55.5 % of the endoscopes that were later shown to be contaminated (95 % confidence interval [CI] 49.2 - 61.8). Multivariable analysis showed that the use of storage cabinets for heat-sensitive endoscopes significantly reduced the risk of endoscope contamination (odds ratio [OR] 0.23, 95 %CI 0.09 - 0.54; P < 0.001) and that the use of endoscopes older than 4 years significantly increased this risk (OR ≥ 6 vs. < 2 years 2.92, 95 %CI 1.63 - 5.24; P < 0.001).Microbiological culture technique, mainly incubation duration, strongly influenced the results of endoscope sampling. Samples should be cultured for more than 2 days to improve the detection of contaminated endoscopes. Particular attention should be paid to endoscopes older than 2 years and to those that are not stored in storage cabinets for heat-sensitive endoscopes.
The mythical readmissions explosion
Authors: A S Weinstein
Journal: American Journal of Psychiatry (1983)

During the past decade and a half, readmissions increased substantially as a proportion of all admissions to state mental hospitals, and the absolute number of readmissions appeared to rise. These trends were interpreted widely, but incorrectly, as reflecting an accelerated rate of return to the hospitals by discharge patients. Most of the rise in the readmission percentage in New York State mental health facilities was due to a drop in first admissions, and the apparent increase in the number of readmissions was entirely accounted for by several statistical artifacts. There was no appreciable increase in the rate of patients' rehospitalization within given periods of time after their release.
Abstract 13: Individualized approach for ovarian cancer: Identification of potential therapeutic targets based on genomic analyses, testing efficiency of treatments, and monitoring
Authors: Faye R. Harris, Geoffrey C. Halling, Marc A. Becker, Paul Haluska, George Vasmatzis, Irina V. Kovtun
Journal: Clinical Cancer Research (2016)

Abstract Ovarian cancer (OCa) is fifth leading cause of death among women. Most of OCa patients diagnosed with high stage invasive disease. Although, majority experience remission after surgical debulking and adjuvant chemotherapy, about 80% of patients relapse and/or develop chemoresistant disease. More efficient diagnostics and therapies are needed to improve outcome in ovarian cancer. We used an integrated approach to characterize genomic rearrangements in serous OCa inordet to identify potentially targetable alterations and test treatments with corresponding drugs using matching mouse avatar models. Mate-pair next generation sequencing protocol and BIMA2 algorithm were used to identify chromosomal rearrangements, including gene fusions and copy number changes, in primary tumors. Further analysis was then performed to determine alterations that may also be therapeutically targeted. Total of 25 primary tumors were analyzed, out of which four were selected for genomically guided treatments in corresponding mouse avatars. The tumors propagated in the selected mouse lines were also sequenced and showed identical to original patient tumor landscape of rearrangements. In addition, the selected targetable alterations were validated in both patient and avatar tumor DNA. For several of the analyzed cases pre-surgical and postsurgical blood was available for detection of selected alterations in cell free circulating tumor DNA. The analysis revealed presence of selected rearrangements in pre-surgical blood of all tested cases and in a number of those that showed presence of the disease after surgery. In summary, we showed that the whole genome sequencing of DNA rearrangements in conjunction with analyses of therapeutic targets and treatment testing in mouse avatars, developed using primary tumors, is a promising approach to aid treatment decisions for individual ovarian cancer patients. Note: This abstract was not presented at the conference. Citation Format: Faye R. Harris, Geoffrey C. Halling, Marc A. Becker, Paul Haluska, Jr., George Vasmatzis, Irina V. Kovtun. Individualized approach for ovarian cancer: Identification of potential therapeutic targets based on genomic analyses, testing efficiency of treatments, and monitoring. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr 13.
Population-Level Representation of a Temporal Sequence Underlying Song Production in the Zebra Finch
Authors: Michel A. Picardo, Josh Merel, Kalman A. Katlowitz, Daniela Vallentin, Daniel E. Okobi, Sam E. Benezra, Rachel C. Clary, Eftychios A. Pnevmatikakis, Liam Paninski, Michael A. Long
Journal: Neuron (2016)
Abstract A06: Characterization of a novel p53-regulated embryonic stem cell-specific lncRNA that safeguards pluripotency
Authors: Abhinav K. Jain, Kadir C. Akdemir, Yuanxin Xi, Ryan L. McCarthy, Kendra Allton, Bruce Aronow, Chunru Lin, Wei Li, Liuqing Yang, Michelle C. Barton
Journal: Cancer Research (2016)

Abstract Recent work shows that long non-coding RNAs (lncRNAs), transcribed from 80% of our genomes, play important roles in gene regulation and are associated with disease pathogenesis. However, there is a broad gap in our knowledge regarding any contributions of lncRNAs in mediating p53 response or regulating stem cell state. Here, we report our discovery of lncRNAs that fine-tune p53's transcriptional outcomes in differentiating human embryonic stem cells (hESCs). By integrating RNA-Seq with p53 ChIP-Seq analyses along with active or repressive histone marks of hESCs undergoing differentiation, we defined a high-confidence set of 40 lncRNAs that are p53 transcriptional targets. We found that p53 directly regulates nuclear lncRNAs, which are either activated (HOTAIRM1) or repressed (lncPRESS-1) during hESC differentiation. Single-cell gene expression analysis during lineage-specific hESC differentiation revealed that lncPRESS-1 is a novel pluripotency-specific, p53-regulated transcript with expression tightly correlated with OCT4, NANOG and PRDM14. Loss-of-function of lncPRESS-1 results in diminished pluripotency and spontaneous differentiation of hESCs. In addition, mass cytometry-based multi-parametric analysis at a single cell level revealed that depletion of lncPRESS-1 results in overall loss of hESC pluripotency with marked induction of an ectoderm specific gene-signature. Further, we show that lncPRESS-1 physically interacts with SIRT6 and restrains its chromatin localization to maintain high levels of histone H3 Lys-56 (H3K56) and Lys-9 (H3K9) acetylation at promoters of pluripotency genes to sustain a chromatin architecture that favors pluripotency. In summary, we describe a novel pluripotency-specific lncRNA that safeguards the hESC state by disrupting SIRT6 activity. Since lncPRESS-1 is repressed by p53, we believe that cancers that harbor mutant TP53 will have robust expression of this lncRNA. Further investigations are underway to determine the disease relevance of lncPRESS-1 and correlation with p53-mutations. Citation Format: Abhinav K. Jain, Kadir C. Akdemir, Yuanxin Xi, Ryan L. McCarthy, Kendra Allton, Bruce Aronow, Chunru Lin, Wei Li, Liuqing Yang, Michelle C. Barton. Characterization of a novel p53-regulated embryonic stem cell-specific lncRNA that safeguards pluripotency. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr A06.
A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation
Authors: Mahima Swamy, Katharina Beck-Garcia, Esmeralda Beck-Garcia, Frederike A. Hartl, Anna Morath, O. Sascha Yousefi, Elaine Pashupati Dopfer, Eszter Molnár, Anna K. Schulze, Raquel Blanco, Aldo Borroto, Nadia Martín-Blanco, Balbino Alarcon, Thomas Höfer, Susana Minguet, Wolfgang W.A. Schamel
Journal: Immunity (2016)
Incidence of Normocalcemic Hyperparathyroidism in Idiopathic Hypercalciuria: Evaluation by Dietary Calcium Deprivation Test
Authors: G.F. Mazzuoli, E.D. Erasmo, D. Mancini, L. Malaguti Alberti, A. Scarda, U. Bracci, L. Miano
Journal: European Urology (1981)
Severe combined immunodeficiency disease. Characterization of the disease and results of transplantation
Authors: M. M. Bortin
Journal: JAMA (1977)

Pretransplant and posttransplant data for 69 patients with severe combined immunodeficiency disease are presented. Both B and T lymphocyte functions were absent in approximately 80% of the children and markedly depressed in the remainder. Transplantation of marrow from HLA genotypically identical donors provided the highest six-month survival rate (63%); six-month survival rates for patients who received fetal tissue transplants (43%) or marrow from mixed leukocyte culture (MLC) negative donors (38%) were significantly higher (<i>P</i>&lt;.05) than for patients treated with marrow from MLC positive donors (5%). Additional factors appeared to influence survival and the severity of graft-vs-host (GVH) disease. Patients more than 6 months of age had more intense GVH disease than younger patients. Survival rates were lower and GVH disease more intense when boys received transplants from girl donors than the reverse. (<i>JAMA</i>238:591-600, 1977)
Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction
Authors: María Luisa Lozano, Aaron Cook, José María Bastida, David S. Paul, Gemma Iruin, Ana Rosa Cid, Rosa Adan-Pedroso, José Ramón González-Porras, Jesús María Hernández-Rivas, Sarah J. Fletcher, Ben Johnson, Neil Morgan, Francisca Ferrer-Marin, Vicente Vicente, John Sondek, Steve P. Watson, Wolfgang Bergmeier, José Rivera
Journal: Blood (2016)
The Genomic Landscape Of Primary Central Nervous System Lymphomas
Authors: Esteban Braggio, Brian Patrick O'Neill, Scott Van Wier, Juhi Ojha, Jackline ayres-Silva, Riccardo Valdez, Jan Egan, Ellen McPhail, Maria Beatriz Lopes, David Schiff, Raoul Tibes, Keith Stewart, Rafael Fonseca
Journal: Blood (2013)
Abstract P4-04-13: Comparison of tumor and stroma CD73 expression with TLR9 and survival in breast cancer
Authors: K Selander, M Mella, J Kauppila, P Karihtala, A Jukkola-Vuorinen, P Auvinen, Y Soini, S Kauppila, K-M Haapasaari, K Harris, K Vuopala
Journal: Cancer Research (2016)

Abstract CD73 is a 5' ectonuclease that catalyzes the conversion of cyclic AMP into the highly immunosuppressive adenosine in extracellular space. In addition to the cells of the immune system, CD73 is highly expressed in various cancer cell lines and clinical cancer tissues. Toll like receptor-9 (TLR9) is a cellular DNA-receptor that is highly expressed in breast cancer. Both CD73 and TLR9 expression have recently been associated with TNBC prognosis but the mechanisms how these proteins possibly contribute to TNBC pathophysiology remains poorly understood. TLR9 and CD73 expression has been shown to be mutually regulated in various cell types. Whether this is the case in cancer is unknown. The aim of this study was to investigate the mutual role of TLR9 and CD73 in breast cancer (BC). Specifically our hypothesis was that TLR9 and CD73 expression correlate in TNBC. We compared immunohistological tumor TLR9 and CD73 expression scores using a previously characterized breast cancer (BC) cohort (n=184) with follow-up time of &amp;gt; 10 years. We did not discover a connection between TLR9 and CD73 expression in tumor cells in BC. There was a trend for increased survival among patients that had high tumor cell CD73 expression, as compared with the lower tumor cell CD73 expression groups. There was a trend for a better survival among TNBC patients that had lower stromal CD73 expression, as compared with those TNBC patients that had higher stromal CD73 expression. No such difference was detected among patients with non-TNBC tumors. Our results suggest that stromal vs. tumor cell CD73 expression have opposite effects on survival in TNBC, but there is no connection between CD73 and TLR9 expression. Our conclusions are limited by low sample numbers. Citation Format: Selander K, Mella M, Kauppila J, Karihtala P, Jukkola-Vuorinen A, Auvinen P, Soini Y, Kauppila S, Haapasaari K-M, Harris K, Vuopala K. Comparison of tumor and stroma CD73 expression with TLR9 and survival in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-04-13.
Aminoacidurias Due to Inherited Disorders of Metabolism
Authors: George W. Frimpter
Journal: New England Journal of Medicine (1973)

DISORDERS of the phenylalanine and tyrosine system, trans-sulfuration, the Krebs-Henseleit urea cycle, the branched-chain amino acids, the imino acids are considered here in groups. Others have to be discussed as more isolated entities. Although various organizations are possible, the suggestions of others have been largely followed for the convenience of the reader.Phenylalanine and Tyrosine (Figure 1)Phenylalanine Phenylketonuria (PKU). This disorder, which is due to failure of hydroxylation of phenylalanine to tyrosine, has long been considered the prototype of aminoacidurias associated with mental retardation. Perry and his colleagues proposed that mental retardation from this cause was related to low . . .