tbuckley/cabot-search huggingface dataset:
Reconstruction of the Cervical Esophagus
Authors: C M O'Conor, E Cordova, S Saade, P Quiroga
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Did the IRB Approve This?
Authors: Margaret Tempero
Journal: Journal of the National Comprehensive Cancer Network (2016)

Margaret Tempero, MD, is a Professor of Medicine and Director of the UCSF Pancreas Center and editor-in-chief of JNCCN. Her research career has focused on pancreatic ductal adenocarcinoma, especially in the area of investigational therapeutics. Dr. Tempero has served on the ASCO Board of Directors and as ASCO President. She currently serves on the ASCO Conquer Cancer Foundation Board. She codirected the AACR/ASCO Methods in Clinical Cancer Research and taught this course and similar courses in Europe and Australia. She was founding Chair of the NCI Clinical Oncology Study Section and served as a member and Chair of the NCI Board of Scientific Counselors Subcommittee A. She is a member of the Scientific Steering Committee and Chair of the Clinical and Translational Study Section for the Cancer Prevention & Research Institute of Texas. She is or has been on the Scientific Advisory Boards of the Lustgarten Foundation, the Pancreatic Cancer Action Network, the V Foundation, The Alberta Canada Cancer Board, and the EORTC. She served as a member of the Oncology Drug Advisory Committee for the FDA. She has served as Deputy Director and Interim Director for the UNMC Eppley Cancer Center. She is Chief Emeritus of the Division of Medical Oncology at UCSF and served as the founding Deputy Director and Director of Research Programs at the UCSF Helen Diller Family Comprehensive Cancer Center. Did the IRB Approve This?
Occurrence of haemagglutinin mutation D222G in pandemic influenza A(H1N1) infected patients in the West of Scotland, United Kingdom, 2009-10
Authors: R S Miller, A R MacLean, R N Gunson, W F Carman
Journal: Eurosurveillance (2010)

Preview this article: Occurrence of haemagglutinin mutation D222G in pandemic influenza A(H1N1) infected patients in the West of Scotland, United Kingdom, 2009-10, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/16/art19546-en-1.gif
Beneficial effect of <i>Lactococcus lactis</i> NCC 2287 in a murine model of eosinophilic esophagitis
Authors: S. Holvoet, R. Doucet‐Ladevèze, M. Perrot, C. Barretto, S. Nutten, C. Blanchard
Journal: Allergy (2016)

Eosinophilic esophagitis (EoE) is a severe inflammatory disease of the esophagus which is characterized histologically by an eosinophilic infiltration into the esophageal tissue. The efficacy of probiotics in the context of atopic diseases has been well investigated but, to date, there has been no study which has evaluated probiotic effects on EoE inflammation. This study sought to identify a probiotic which improves esophageal inflammation in experimental EoE.Two candidate probiotics, Lactococcus lactis NCC 2287 and Bifidobacterium lactis NCC 2818, were tested in a murine model of EoE elicited by epicutaneous sensitization with Aspergillus fumigatus protein extract. Administration of bacterial strains in drinking water was used, respectively, as a preventive or treatment measure, or continuously throughout the study. Inflammatory parameters were assessed in the esophagus, skin, and lungs after allergen challenge.In this EoE model, supplementation with L. lactis NCC 2287 significantly decreased esophageal and bronchoalveolar eosinophilia but only when given as a therapeutic treatment. No significant effect on eosinophilia was observed when NCC 2287 was given as a preventive or a continuous intervention. NCC 2287 supplementation had no significant effect on immunoglobulin levels, skin symptom scores, or on transepidermal water loss. Supplementation with another probiotic, B. lactis NCC 2818, had no significant effect on esophageal eosinophilia.We identified a L. lactis strain, able to attenuate esophageal eosinophilic inflammation in a preclinical model of EoE. This effect is strain specific and depends on the timing and duration of bacterial supplementation. Confirmation of these observations in human clinical trials is warranted.
Pharmacokinetic interaction of disulfiram and antidepressants
Authors: D A Ciraulo, J Barnhill, H Boxenbaum
Journal: American Journal of Psychiatry (1985)

Intravenous imipramine and desipramine were administered to two detoxified alcoholics before and during disulfiram treatment. Tricyclic pharmacokinetic parameters, determined from plasma samples over 48 hours, indicated decreased total body clearance, increased elimination half-life, and higher peak plasma levels during disulfiram treatment.
Tumors of the Pleura Induced With Asbestos and Fibrous Glass
Authors: Paul Gross
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Tumors of the Pleura Induced With Asbestos and Fibrous Glass Get access Paul Gross Paul Gross Department of Pathology South Carolina School of Medicine, Charleston, South Carolina Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 1, July 1973, Pages 315–317, https://doi.org/10.1093/jnci/51.1.315 Published: 01 July 1973
Dexamethasone suppression test and cortisol circadian rhythm in primary degenerative dementia
Authors: M Raskind, E Peskind, M F Rivard, R Veith, R Barnes
Journal: American Journal of Psychiatry (1982)

Before the dexamethasone suppression test (DST) can be accepted as a valid diagnostic tool for differentiating depression from dementia, it must be demonstrated that dementing illnesses per se are not associated with a positive DST. The authors studied cortisol circadian rhythm and the overnight DST in 15 nondepressed patients with advanced primary degenerative dementia and 15 normal control subjects. Seven dementia patients and no control patients were DST positive. The DST-positive dementia patients had a blunted predexamethasone circadian cortisol rhythm. These results cast doubt on the utility of the DST in diagnosing depression that complicates advanced primary degenerative dementia.
PTH-003 Outcomes following endoscopic mucosal resection (emr) of colonic polyps in a tertiary centre: a three year experience
Authors: P Nesargikar, L Amadio, C Noble, G Wilson, M Potter
Journal: Gut (2015)

<h3>Introduction</h3> EMR for large sessile and flat colonic polyps has minimised the need for surgical intervention with acceptable outcomes. The aim of this study was to evaluate the indications, outcomes, complications and recurrence rates following EMR. <h3>Method</h3> Patients who underwent EMR over a three year period from 2011 to 2014 were analysed retrospectively for technique, polyp characteristics, pathology, recurrence rates and complications. <h3>Results</h3> Eighty EMRs were carried out over a 3 year period (male:female 52:28, mean age 68.25 yrs). The median polyp size was 28.5 mm (range 10 mm–60 mm). The most common sites of EMR were rectosigmoid (36%), caeum (27.5%) and ascending colon (17.5%). Only two polyps failed to be lifted, with majority of polyps retrieved piecemeal. Tubolovillous adenomas (75%) were the predominant histological pattern, with low grade dysplasia present in 10% (8/80), high grade dysplasia in 27.5% (22/80) and polyp cancers in 3.75% (3/80) of patients. Early follow up was at a median of 5 months, with further endoscopic review determined by BSG guidelines. Polyp recurrence rate at the site of original EMR was 17.5%. All were successfully treated endoscopically. Complications included bleeding (n = 4), abdominal pain (n = 1), post polypectomy syndrome (n = 1) and perforation (n = 1). Of these 7 patients, two patients required operative intervention and rest were managed conservatively. APC was used in 64% patients and was associated with 6 of the above 7 complications. <h3>Conclusion</h3> This study is one of the bigger studies reported in UK to date, and we have shown that EMR is a safe procedure with few complications and acceptable recurrence rates. The most significant complication of perforation was encountered in the early days of EMR. This study demonstrates that with experience on the learning curve, EMR can be safely practiced and advocated for large colonic polyps. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Repici A <i>et al</i>. Endoscopic mucosal resection for early colorectal neoplasia: pathologic basis, procedures, and outcomes. Dis Colon Rectum 2009;<b>52</b>:1502–15 Seitz U <i>et al</i>. Is endoscopic polypectomy an adequate therapy for malignant colorectal adenomas? Presentation of 114 patients and review of the literature. <i>Dis Colon Rectum</i>2004;47(11):1789–96 Carvalho R <i>et al</i>. Endoscopic mucosal resection of large colorectal polyps: prospective evaluation of recurrence and complications. Acta Gastroenterol Belg 2013;<b>76</b>:225–30
Film: The Island
Authors: Jason O'Neale Roach
Journal: BMJ (2005)

One of the most intriguing and emotive debates of our time is about human reproductive cloning. Ever since Ira Levin's 1976 thriller The Boys from Brazil, fascination with carbon copies of human beings has permeated both fiction and journalism. It has also preoccupied a minority of renegade scientists bent on offering human cloning as a reproductive option, despite widely acknowledged safety concerns.​concerns.




Figure 2



Double act: Scarlett Johansson and Ewan McGregor as clones




This fascination continues with the release of Michael Bay's latest film, The Island. Ewan McGregor and Scarlett Johansson star as clones in this high octane action adventure, which speculates on the commercial use of cloning for spare parts. The twist is that their rich and famous owners do not know that their “insurance policies” are in fact conscious beings. When two of the clones discover that they are no more than vessels for spare parts, they escape captivity to try to find their makers.

As the plot unravels, it quickly becomes clear that Bay's primary objective was not serious reflection. The film begins as a stark portrait of a carefully controlled underclass, hinting at Huxley's Brave New World. However, the tension gradually gives way to action sequences that make James Bond films look remarkably credible. In spite of this, there are still moments to savour—for example, when Scarlett Johansson's clone character faces her counterpart.

Bay clearly conveys his view of where the motivation for cloning comes from: whether in the scientist's quest for control or the individual's wish to cheat death, Bay sees the root cause as the desire to play God.

Bay's portrayal of the human condition is remarkably bleak. For example, the sole positive attributes of being human, embodied for us in the ever funny Steve Buscemi, seem to be strip joints and bad jokes. Human replicas can be made to function normally only by fixing their eyes on an unreal future on a paradise Island. So while this parable warns against playing God, it also portrays the hope of an afterlife as a convenient human invention. The mercenary hired to capture the clones (Djimon Hounsou) provides the one ray of hope as he gradually resolves to uphold human dignity.

Bay's film ultimately delivers what we have come to expect from his Hollywood blockbusters (his other films include Pearl Harbor, Armageddon, and Bad Boys)—big stunts, white knuckle chase scenes, and gratuitous product placement. But as blockbusters go, this is at least a step in the right direction. Unusually, it has a plot and, despite the frenetic pace, the cast keep it alive. If you are prepared to dig below the surface, it will certainly leave you thinking.
Evaluation prompting transition from enhanced to routine surveillance of lymphogranuloma venereum (LGV) in the Netherlands
Authors: M Kivi, F. D.H. Koedijk, M van der Sande, M  J W van de Laar
Journal: Eurosurveillance (2008)

In 2004, a lymphogranuloma venereum (LGV) epidemic among men who have sex with men in the Netherlands motivated the introduction of enhanced surveillance. We evaluated the acceptability of the enhanced LGV surveillance in the Netherlands in 2004-2005 to provide recommendations for future surveillance. Completeness of requested patient information was analysed. All 12 sexually transmitted infection (STI) health services participating in the 2004-2005 STI surveillance completed evaluation questionnaires and rated surveillance system features from 1="very poor" to 5="very good". Information from enhanced LGV surveillance was available for 34 (33%) of 104 cases. For these 34 cases, median proportions of response decreased successively for clinical information (100%), sexual anamnesis (71%) and details about the last sex partners (44%). A median score of 4 ("good") was assigned to simplicity, required resources and surveillance information requested and distributed. Seven respondents favoured continuation of LGV surveillance, whereof six preferred modifications, usually meaning less extensive surveillance. In conclusion, the enhanced LGV surveillance was generally regarded as adequate. However, it was limited by low completeness, underlining the need to keep requested information to a minimum. The routine STI surveillance now includes LGV diagnosis and, following this evaluation, the additional enhanced surveillance was discontinued. However, occasional cases justify alertness and LGV remains under routine STI surveillance in the Netherlands.
Urate Excretion in Patients With Acute Leukemia&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: James F. Holland, M.D., William Sharpe, M.D., Louise M. Mamrod, B.A., Edward Dowd, Ph.D., Marian Hartsock
Journal: JNCI Journal of the National Cancer Institute (1959)

Urinary urate excretion was measured in patients with acute lymphocytic leukemia (ALL) and acute myelocytic leukemia (AML), while on a low-purine diet in the 5 days immediately before and the 10 days after onset of antileukemic treatment. As a group, ALL patients demonstrated increased excretion in the posttreatment period. Observations in individual patients revealed that this metabolic response was not essential to attainment of a complete remission of the leukemia, nor did its presence assure that remission would ensue. As a group, patients with AML who did not respond to treatment with remission or a precipitous fall in leukocytes had no significant change in their urate excretion. Attempts to identify those patients who attained remission, on the basis of their urate excretion before treatment, were not successful.
Case 35-1972
Authors: James E. Dalen, Thomas McC. Chesney
Journal: New England Journal of Medicine (1972)

PRESENTATION OF CASEA 45-year-old man was admitted to the hospital because of dyspnea.At the age of 10 years he had scarlet fever; he was advised to limit his activities because of a cardiac murmur. Fifteen years before admission he was treated for subacute bacterial endocarditis; examination disclosed a Grade 4 apical systolic murmur and a questionable Grade 1 apical diastolic murmur. Seven years before entry atrial fibrillation developed; digitalis and penicillin were prescribed, and he was admitted to another hospital, where physical examination revealed a Grade 4 pansystolic murmur at the cardiac apex that radiated to the left . . .
Weight reduction at the work site: a promise partially fulfilled
Authors: K D Brownell, A J Stunkard, P E McKeon
Journal: American Journal of Psychiatry (1985)

Three consecutive studies of weight reduction at the work site were conducted with 172 female union members, who participated in 16-week behavioral group programs. There was no significant difference in weight loss over the three studies, but attrition decreased from 57.5% to 33.8% and weight loss maintenance improved. Groups that met three to four times weekly had less attrition than those which met once a week, but had no more weight loss. These behavioral weight reduction programs were as effective as self-help and commercial groups, and lay leaders produced results equivalent to those produced by professional therapists at one-third the cost.
Janet redivivus: the centenary of L'automatisme psychologique
Authors: J C Nemiah
Journal: American Journal of Psychiatry (1989)

The recent festivities celebrating the bicentennial of the French Revolution have overshadowed the remembrance of another occurence in French history that, from a scientific point of view at least, is perhaps of equal magnitude - the publication in 1889 of Pierre Janet's L'automatisme psychologique, whose centenary is honored by a Special Article, «Pierre Janet and the Breakdown of Adaptation in Psychological Trauma,» which follows this editorial
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
Authors: Amit V. Khera, Hong-Hee Won, Gina M. Peloso, Kim S. Lawson, Traci M. Bartz, Xuan Deng, Elisabeth M. van Leeuwen, Pradeep Natarajan, Connor A. Emdin, Alexander G. Bick, Alanna C. Morrison, Jennifer A. Brody, Namrata Gupta, Akihiro Nomura, Thorsten Kessler, Stefano Duga, Joshua C. Bis, Cornelia M. van Duijn, L. Adrienne Cupples, Bruce Psaty, Daniel J. Rader, John Danesh, Heribert Schunkert, Ruth McPherson, Martin Farrall, Hugh Watkins, Eric Lander, James G. Wilson, Adolfo Correa, Eric Boerwinkle, Piera Angelica Merlini, Diego Ardissino, Danish Saleheen, Stacey Gabriel, Sekar Kathiresan
Journal: Journal of the American College of Cardiology (2016)
AB1243-HPR The Relationship Between Kinesiophobia and Pain, Physical Activity, Depression, Fatique, Disease Activity and Quality of Life in Patients with Systemic Lupus Erythematosus
Authors: S. Baglan, S. Karatay, A. Tufan, D. Oskay, Z. Tuna
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Promoting physical activity is one of the major goals in the management of systemic lupus eryhthematosus (SLE) given negative impact of sedentary life style on longterm prognosis. Less is known about SLE patients9 willingness to participate in physical activity. Kinesiophobia is an excessive, irrational, and debilitating fear of physical movement and activity resulting from a feeling of vulnerability to painful injury. <h3>Objectives</h3> To investigate relationship between kinesiophobia and physical activity level, disease activity, depression, fatique, pain and quality of life in women with SLE. <h3>Methods</h3> 69 pre-menopausal women (mean age 37.50±9.56; range from 18 to 55 years old) were included in this study. Patient demographics and clinical manifestations were recorded. Kinesiophobia was assessed with Tampa Scale for Kinesiophobia (TSK, a score of &gt;37 was considered as high kinesiophobia level), physical activity was assessed with International Physical Activity Questionnare (IPAQ), disease activity was assessed with Systemic Lupus Erythematosus Disease Activity Index (SLEDAI), fatique was assessed with Fatique Severity Scale, depression was assessed with Beck Depression Inventory (BDI), pain was assessed with McGill Pain Scale (MPS) and quality of life was assessed with Nottingham Health Profile (NHP). Correlations between these measures were analyzed. <h3>Results</h3> Kinesiophobia was found to be very common in SLE affecting 66.6% of patients. There was a positive correlation between TSK score and depression (r=0,335, p=0,005) and some subscales of NHP [social isolation (r=0,350, p=0,003), emotional reactions (r=0,435, p&lt;0.001)]. However there was no correlation between TSK score and physical activity level, fatique, sleep, disease activity, pain and the rest of subscales of NHP (pain, physical activity and fatique) (p&gt;0.05). <h3>Conclusions</h3> According to our study, the reason of activity avoidance and fear of movement of the patients with SLE is more associated with the psychological problems than the pain aggravated with activity. In the treatment of SLE, patients need psychological support to promote physical activity level which improves survival and quality of life. <h3>References</h3> Costenbader KH, Wright E, Liang MH, Karlson EW. Cardiac risk factor awareness and management in patients with systemic lupus erythematosus. Arthritis Care Res 2004; 51: 983–988 CA Mancuso, M Perna, AB Sergant, JE Salmon: Perception and measurements of physical activity in patients with systemic lupus erythematosus. Lupus 2011 20:231 <h3>Disclosure of Interest</h3> None declared