tbuckley/cabot-search huggingface dataset:
O7.03 * IDH-1 MUTATED GLIOBLASTOMAS HAVE A LESS INVASIVE PHENOTYPE THAN IDH-1 WILD TYPE GLIOBLASTOMAS: A DIFFUSION TENSOR IMAGING STUDY
Authors: S. J. Price, N. R. Boonzaier, V. Lupson, T. Larkin
Journal: Neuro-Oncology (2014)

INTRODUCTION: IDH-1 mutated glioblastomas are associated with a better prognosis than glioblastomas with wild type IDH-1. Most explanations for this improved prognosis is due to these tumours responding better to therapy. Recent work has suggested they have a different behaviour. Diffusion tensor imaging (DTI) is able to explore the invasive behaviour of glioblastomas and can identify a number of invasive phenotypes. Approximately 20% have a minimally invasive pattern that have improved survival. This study aims to look at differences in invasive behaviour in pre-operative GBMs with IDH-1 mutation status. METHODS: Patients with resectable glioblastomas were imaged at 3T with a protocol including DTI. The DTI data was decomposed into isotropic (p) and anisotropic (q) components and these abnormalities were outlined. The difference between these regions have been shown previously to be the region of invasion and was classified according to previously published classification. The tumours were resected and the IDH-1 status assessed using immunohistochemistry for the R132 mutation. RESULTS: 68 patients were studied with 9 IDH-1 mutated GBMs, and 57 with wild type IDH-1. All of the IDH-1 tumours exhibited minimally invasive DTI patterns. Only 5 (8%) of the IDH-1 negative tumours were minimally invasive, 14 (24%) had a localised invasive pattern and the majority 41 (69%) had a diffuse pattern of invasion. In all of the IDH-1 group there was the tumour surrounded by intact white matter as confirmed by diffusion tissue signature measurements. CONCLUSION: We have shown that IDH-1 mutated GBM have a different invasive behaviour compared to the non-mutated GBMs. This difference is seen at first presentation and is not related to response to therapy. This lack of invasion can help explain the better prognosis of this GBM subtype.
SP0073 Molecular Control of Cell Fate Determination in Cartilage and Joint Development
Authors: V. Lefebvre
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> The healthy development and adult maintenance of the various structures that make up our skeleton rely on tight coordination of multiple events. These events include cell fate decisions made by multipotent mesenchymal progenitor/stem cells and differentiated cell types to either survive or die, proliferate or growth arrest, migrate or settle, and maintain stemness or differentiate. These decisions are controlled by both cell-autonomous and non-cell-autonomous mechanisms, i.e., mechanisms dependent on intrinsic properties of cells and on external cues, respectively. A pivotal decision made by every mesenchymal cell of the onset of skeletogenesis is to be or not to be a chondrocyte. Sox9 forms with its functional partners, Sox5 and Sox6, a trio of transcription factors required cell-autonomously for the commitment and differentiation of mesenchymal cells into chondrocytes. In contrast, beta-catenin is a structural protein and transcriptional co-activator required to divert cells from the chondrocyte lineage and secure their differentiation into non-chondrocytic cell types. These cell types include prospective articular joint cells. Antagonism between Sox9 and beta-catenin thus governs the proper design, development and articulation of all cartilage templates of future bones. Although it acts cell-autonomously, beta-catenin is critically dependent upon canonical Wnt signaling to be stable and thus capable of achieving its functions. This pathway acts for a large part non-cell-autonomously. As of today, it remains unknown whether articular progenitor cells and other non-chondrocytic cell types use cell-autonomous mechanisms to stabilize beta-catenin and thereby secure their lineage fate. We will show here that we have newly identified a distinct trio of Sox proteins that has this unique property. This trio is composed of Sox4, Sox11, and Sox12, the three members of the SoxC group. Their inactivation in multipotent mesenchymal progenitors in the mouse embryo results in a severe skeletal dysplasia. Cartilage primordia form, but remain tiny and are fused with each other due to a total absence of articular joints. The SoxC genes are actively expressed in mesenchymal progenitor cells, including presumptive joint cells. They have a key role in stabilizing beta-catenin and thereby in repressing Sox9 expression and securing the non-chondrocytic fate of the cells. Thus, the SoxC non-chondrocytic trio and the Sox5/6/9 chondrogenic trio have opposite actions that are both necessary to decide the fate of mesenchymal progenitor/stem cells and thereby develop a harmonious and fully functional skeleton, including articular joints. Future studies are necessary to determine whether and how these two Sox trios continue to direct and secure cell fate in adult joints under healthy and rheumatic conditions. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6330
Do Patients in Whom Myocardial Infarction Has Been Ruled out Have a Better Prognosis after Hospitalization Than Those Surviving Infarction?
Authors: John S. Schroeder, Irene H. Lamb, Marie Hu
Journal: New England Journal of Medicine (1980)

To determine the prognosis after hospitalization of patients hospitalized with acute chest pain in a coronary-care unit, we undertook a prospective study of 211 consecutive admissions to the Stanford Coronary Care Unit. On the basis of predetermined criteria, 16 patients were found to have noncardiac chest pain, and myocardial infarction was ruled out in 89, one of whom died in the hospital. Infarction was documented in 84 others, six of whom died in the hospital. Prospective follow-up after hospitalization was carried out in the 88 patients in whom infarction was ruled out and in the 78 patients who survived infarction. The rate of myocardial infarction or death was 8.0 per cent at six months and 21.6 per cent at a mean of 27.8 months of follow-up for patients who had infarction ruled out, as compared with 7.7 per cent at six months and 21.8 per cent at a mean of 27.8 months of follow-up for those who had a documented infarction during the initial hospitalization. Cardiomegaly, congestive heart failure, and angina after discharge from the hospital tended to increase the risk of morbidity and mortality in both groups. The patient hospitalized with acute ischemic chest pain without evolution of a myocardial infarction has a six to 24-month prognosis similar to that of the patient hospitalized with an acute infarction, and therefore requires similar diagnostic and therapeutic assessment. (N Engl J Med. 1980; 303:1–5.)
Abstract 3287: Investigating the role of PTX3 in cervical cancer
Authors: Yumi Wada, Osamu Akutagawa, Hirotaka Nishi, Chinatsu Higuma, Fumitoshi Terauch, Keiichi Isaka
Journal: Cancer Research (2010)

Abstract Tumor progression requires tumor angiogenesis, as newly-formed blood vessels supply necessary oxygen and nutrition to the growing tumor. Many unknowns remain in our understanding of the cancer metastasis process. Pentraxin3 (PTX3) is categorized as a long pentraxin in the pentraxin family and is produced by macrophages and vascular endothelial cells. PTX3 concentrations reportedly increase with exposure to IL-1 and TNF-α. Recently, PTX3 has gained attention as a potential marker that reflects inflammation in blood vessels, as well as that which may predict the onset of various diseases, including vascular diseases. The present study examined whether or not an analysis of PTX3 expression may contribute to a mechanistic understanding of carcinogenesis (metastasis) of cervical cancer. Subjects and Methods: Cervical Cancer Cell Lines A comparative study of PTX3 was performed at the protein level and the RNA level by cultivating each of the cervical cancer cell lines CasKi and SiHa under normal conditions and under hypoxic conditions. Clinical Tissue Samples Normal cervical tissues (n=7) and cervical cancer tissues (n=20) were collected from subjects after an explanation of the study was given and consent was obtained. PTX3 expression in both groups was compared. All measurements were taken using ELISA, Western blot, and real time RT-PCR methods. Results: Increased PTX3 expression was observed both at the protein level and at the RNA level in cervical cancer cell lines grown under hypoxic conditions. Conversely, in clinical samples, we observed many samples for which PTX3 expression decreased in cervical cancer samples, contrary to our expectations. Discussion: These results indicate a potential role of PTX3 in the carcinogenesis mechanism of cervical cancer. Further, PTX3 may exhibit cytoprotective effects, which may have played a role in our present study. Future investigation of these results is necessary. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3287.
TRICUSPID ANNULOPLASTY FOR FUNCTIONAL TRICUSPID REGURGITATION IN PATIENTS UNDERGOING MITRAL VALVE REPAIR FOR SEVERE MITRAL REGURGITATION
Authors: Takeshi Kitai, Yukikatsu Okada, Takafumi Yamane, Kitae Kim, Shuichiro Kaji, Tomoko Tani, Yutaka Furukawa
Journal: Journal of the American College of Cardiology (2015)
Case 27-1995
Authors: E.C. Engle, E.T. Hedley-Whyte
Journal: New England Journal of Medicine (1995)

Presentation of CaseA 29-month-old girl was readmitted to the hospital because of increasing ataxia and abnormal eye movements.The child had been born after a 30-week gestation, with a birth weight of 1.35 kg. The mother was reported to have abused alcohol and other drugs, especially medications for pain, throughout gestation. The girl was transferred to this hospital, intubated for approximately 1 week, and discharged at 31/ 2 months. Her early developmental milestones were delayed; her first steps were at 21 months, and she walked in a stable fashion at 24 months. Bilateral esotropia was operated on at 21 . . .
THU0537 Persistence and Dose Escalation of Tumor Necrosis Factor (TNF)-Blockers in us Veterans
Authors: G. W. Cannon, S. L. DuVall, C. Hayden, L. Caplan, J. R. Curtis, K. Michaud, T. Mikuls, A. Reimold, D. H. Collier, D. J. Harrison, G. J. Joseph, B. Sauer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Comparison of adalimumab (ADA), etanercept (ETN), and infliximab (INF) use in clinical practice may provide important insight into the comparative effectiveness and cost of approved therapies. <h3>Objectives</h3> To examine persistence, dose escalation, clinical outcomes, and treatment costs with ADA, ETN, and INF for patients (pts) enrolled in the US Veterans Affairs RA (VARA) registry. <h3>Methods</h3> VARA links to VA pharmacy and administrative databases, and documents longitudinal assessments of disease activity and outcomes. VARA pts initiating ADA, ETN, or INF from 3/18/2003 to 9/30/2010 were identified with follow-up data collected for ≥12 months. This analysis was limited to first treatment course beginning ≥180 days after VARA enrollment. A treatment course was defined as continuous medication dispensing in the absence of ≥90-day gap. Dose escalation was ≥25% increase in weekly dose. Cost was determined by drug costs alone and including drug administration (dispensing/infusion costs). <h3>Results</h3> Data from 563 pts (204 ADA; 290 ETN; 69 INF) were analyzed (Table). No differences in persistence were seen (Fig A). Dose escalation was most common with INF followed by ADA (Fig B). Persistence post-escalation was similar for all agents. Mean DAS28 and change in DAS28 in 61 evaluable pts were similar for each drug. Average annual costs were highest for INF. <h3>Image/graph:</h3> <h3>Conclusions</h3> In VARA, persistence on ADA, ETN and INF was similar. Escalation was most common with INF and least frequent with ETN, and did not impact persistence. Drug costs were higher for INF than ADA and ETN. Persistence and DAS scores were similar regardless of dose escalation. <h3>Acknowledgements</h3> Research funded by VA Research Program and Immunex Corporation, a wholly owned subsidiary of Amgen Inc., and by Wyeth, which was acquired by Pfizer Inc. in October 2009. <h3>Disclosure of Interest</h3> G. Cannon Grant/research support from: Amgen Inc., S. DuVall Grant/research support from: Amgen Inc, Anolinx LLC, Genentech Inc, F. Hoffmann-La Roche Ltd, Merck &amp; Co Inc, Mylan Specialty LP, and Shire PLC, C. Hayden: None Declared, L. Caplan: None Declared, J. Curtis Grant/research support from: Roche/Genentech, UCB, Centocor, CORRONA, Amgen, Pfizer BMS, Janssen, AbbVie, K. Michaud: None Declared, T. Mikuls Grant/research support from: Genentech/Roche, A. Reimold Grant/research support from: Lilly, Novartis, Janssen, Ardea, Consultant for: UCB, D. Collier Shareholder of: Amgen Inc., Employee of: Amgen Inc., D. Harrison Shareholder of: Amgen Inc., Employee of: Amgen Inc., G. Joseph Shareholder of: Amgen Inc., Pfizer Inc., Employee of: Amgen Inc., B. Sauer Grant/research support from: Amgen Inc.
AB0673 Comparison of the duration of ultrasound treatment in patients with subacromial impingement syndrome.
Authors: M. A. Yıldırım, K. öneş, E. coşkun
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> . <h3>Objectives</h3> A prospective, randomized and single-blind study has been performed in order to compare the efficiency of ultrasound treatment of various durations as applied to patients with subacromial impingement syndrome. <h3>Methods</h3> Forty patients, diagnosed with subacromial impingement syndrome, clinical examination and magnetic resonance imaging participated in this study. Patients were divided into two randomized groups of twenty patients. The first group was applied 15 session therapeutic ultrasound (1.5 watts / cm <sup>2</sup>, 1 mHz frequency, 8 minutes), superficial heat (infrared) and transcutaneous electrical stimulation (TENS) therapy combined with exercise; the second group was applied 15 session therapeutic ultrasound (1.5 watts / cm <sup>2</sup>, 1 mHz frequency, 4 minutes), superficial heat (infrared) and transcutaneous electrical stimulation (TENS) therapy combined with exercise. The patients were evaluated before the treatment and after the treatment. Visual analog scale (VAS) was used for pain, University of California at Los Angeles (UCLA) and Constant Scale for shoulder function, Beck Depression İnventory (BDI) for depression level. <h3>Results</h3> There was no statistically significant difference between age, beginning time of pain, sex, education and depression level (p&gt;0,05) before the treatment. Post-treatment evaluation of patients with intra-group VAS, UCLA, Constant, and BDI scores was statistically significant improvement (p&lt;0.001). When the two groups were compared after two weeks treatment, there was no statistically difference between VAS, UCLA, Constant and BDI scores (p&gt;0,05). <h3>Conclusions</h3> Ultrasound therapy in the treatment of subacromial impingement syndrome; pain, activities of daily living, active range of motion was found to have beneficial effects. But in our study, the treatment of subacromial impingement syndrome a 4-minute ultrasound treatment and of an 8-minute advantage to each other could not be detected. <h3>References</h3> &nbsp; <h3>Acknowledgements</h3> . <b>Disclosure of Interest</b>: None Declared
TCT-211 Long Term Clinical And Angiographic Outcome Of The Mini-STAR Technique As A Bail Out Strategy For Percutaneous Coronary Intervention Of Chronic Total Occlusion
Authors: Marouane Boukhris, Salvatore D. Tomasello, Francesco Marzà, Salvatore Azzarelli, Simona Giubilato, Alfredo R. Galassi
Journal: Journal of the American College of Cardiology (2014)
COMPARISON BETWEEN ANTICOAGULATION ALONE AND THROMBOLYSIS PLUS ANTICOAGULATION ON CLOT BURDEN AND RIGHT VENTRICULAR FUNCTION DURING HOSPITALIZATION IN NORMOTENSIVE ACUTE PULMONARY EMBOLISM PATIENTS WITH RIGHT VENTRICULAR DYSFUNCTION
Authors: Kye Hun Kim, Jae Yeong Cho, Hyun Ju Yoon, Youngkeun Ahn, Myung Ho Jeong, Jeong Gwan Cho, Jong Chun Park
Journal: Journal of the American College of Cardiology (2015)
Nothing but wickedness
Authors: T. Dalrymple
Journal: BMJ (2012)

Dr Samuel Johnson had many illnesses, and even more ascribed to him by writers, but he had a strong constitution and lived to what was, for the time, an old age—75. He was interested in physic and was willing to experiment on himself. On his deathbed, frustrated by the inability of his doctors to relieve the gross oedema of his legs, he cut deeply into his own flesh.

Johnson, whom Voltaire (wrongly) called a superstitious dog, believed that science would help to relieve mankind of much misery, but not of misery as such. Living at a time when poverty meant not an income lower than 60% of the median …
Renal Histopathologic Alterations in Patients Treated with Cyclosporine for Uveitis
Authors: Alan G. Palestine, Howard A. Austin, James E. Balow, Tatjana T. Antonovych, Sharda G. Sabnis, Harry G. Preuss, Robert B. Nussenblatt
Journal: New England Journal of Medicine (1986)

To evaluate abnormalities of renal morphology associated with long-term cyclosporine therapy, we obtained percutaneous renal biopsy specimens from 17 patients who had been treated for autoimmune uveitis with cyclosporine for an average of two years. For comparison, we also analyzed renal biopsy specimens from patients with idiopathic hematuria who had not received cyclosporine. The atrophic and sclerosing glomerular and tubulointerstitial lesions in the specimens were assessed to derive a chronicity index. The specimens from the patients treated with cyclosporine showed a significantly higher chronicity index than those from the controls (P<0.00005). All patients who had received cyclosporine had interstitial fibrosis, tubular atrophy, or both. A good functional predictor of the abnormalities in renal morphology was the length of time that a patient's serum creatinine had exceeded the base-line value by more than 50 percent. Chronic pathologic alterations were seen even in patients who had normal renal function at the time of the biopsy. In conjunction with sequential measurements of renal function, renal biopsy may have an important role in defining the type and degree of nephrotoxicity that can develop in patients receiving long-term cyclosporine therapy for autoimmune disease. (N Engl J Med 1986; 314:1293–8.)
FRI0462 Inter-observer variation among conventional radiologist, expert radiologist and rheumatologist, in magnetic resonance imaging (MRI) of the sacroiliac (SI) joints in a group of colombian patients with spondyloarthritis (SPA)
Authors: J. Londono, E. Calvo, P. Peña, A. M. Santos, M. Porras, C. Romero-Sanchez, W. Bautista, S. Segura, R. Valle-Oñate
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The MRI of SI joints, included in the ASAS criteria, is being increasingly used to detect early sacroiliitis and as a tool to measure response to treatment in clinical studies. However, evaluation of the MRI of SI joints has been considered difficult to a non-experienced observer, in which case, Sacroiliitis could be mis diagnosed or delay diagnosis and cost increase. <h3>Objectives</h3> To evaluate the concordance rate of detecting abnormalities of sacroiliac joints on MRI, between a musculoskeletal expert observer and conventional radiologist, in a group of patients with SpA <h3>Methods</h3> 66 patients with diagnosis of SpA according to the ESSG (European Study Group spondyloarthritis), who were attended to a SpA clinic from January to November of 2012 and their MRI films of SI joints and its originals reports by conventional radiologist were selected. Those images were read independently in a second time by a musculoskeletal expert observer. The agreement between two readers was analyzed through the kappa statistic. <h3>Results</h3> The agreement between the two readers (musculoskeletal expert radiologist and conventional radiologist) was poor (K 0.37), on the normal case (K 0.39), and on chronic findings (K0.31), while there was moderate agreement on the presence of acute changes (K 0.45). The agreement between a rheumatologist expert in SpA and a musculoskeletal expert radiologist observer also was analyzed, the agreement was acceptable to be useful in ascertaining acute inflammatory and chronic structural changes due to sacroiliitis (sacroilitis by X-ray K 0,5; acute changes K 0,52, chronic changes K 0,61). <h3>Conclusions</h3> Sacroiliitis can be difficult to detect in early stages of SpA. The agreement for changes due to sacroiliitis by MRI between expert and non- expert radiologist in this study was poor, while between two experts readers (Radiologist and Rheumatologist) was better. Although MRI is highly sensitive in detecting early changes according to other studies, these findings may be no detected by non-expert observers, that's why training of rheumatologists and radiologists in the evaluation of sacroiliac joints on MRI is necessary, to optimize the accuracy of the diagnostic test, avoid mis diagnostic and cost increase. <h3>Disclosure of Interest</h3> None Declared
Abstract 3014: Robust microRNA expression profiling of specific cells in complex archival tissue stained by immunohistochemistry
Authors: Falk Hlubek, Claudia Schuster, Jan Budczies, Thomas Kirchner
Journal: Cancer Research (2010)

Abstract Molecular diagnostics in modern pathology has been limited by the use of formalin-fixed, paraffin-embedded (FFPE) tissues in current routine diagnostic procedures due to modification and degradation of nucleic acids. In particular, molecular analysis of specific cell types potentially important for basic research and biomarker identification is largely prevented in highly complex, solid tissues routinely used in histopathology. Our objective was to establish a sensitive and robust procedure to quantify miRNA expression in specific cells from complex archival colorectal tumor tissue identified by immunohistochemistry. We combined classical immunohistochemistry and isolation of specific tissue cells by lasermicrodissection with the molecular analysis based on miRNA-preamplification and expression analysis by quantitative real-time PCR. Here we show reliable detection of miRNA expression profiles determined from limited amounts of colorectal cancer FFPE-tissues after routine staining procedure. The combination of routinely used FFPE-specimens stained by immunohistochemistry with the molecular analysis of lasermicrodissected complex tumor tissue resulted in robust miRNA expression patterns exclusively obtained from epithelial tumor cells. This approach allows for a detailed molecular analysis of cancer cells and distinct stromal cell types and their in-situ interaction in solid tumors. The methodology can therefore offer new perspectives for basic research and, by comprehensive use of present archival tissue collections linked to clinical databases, facilitate miRNA biomarker identification in defined tissue cells for future diagnostic and therapeutic strategies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3014.
241PD Treatment of locally recurrent prostate cancer following external beam radiotherapy or brachytherapy: In situ gene therapy with iodine-131 and the sodium iodide symporter gene
Authors: B.J. Davis, L.A. Mynderse, T.M. Wilson, G.A. Wiseman, M.K. O'Connor, M.J. Federspiel, D.J. Tindall, J.C. Morris
Journal: Annals of Oncology (2015)
Centers Improve Cancer Control in Appalachia
Authors: D. Artz
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Centers Improve Cancer Control in Appalachia Get access David Artz David Artz Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 24, 18 December 1991, Pages 1791–1792, https://doi.org/10.1093/jnci/83.24.1791 Published: 18 December 1991