tbuckley/cabot-search huggingface dataset:
Quantitative Measurement of Blood Flow Volume in the Major Intracranial Arteries by Using 123I-Iodoamphetamine SPECT
Authors: Shigeki Yamada, Masaharu Kobayashi, Yoshihiko Watanabe, Hidenori Miyake, Marie Oshima
Journal: Clinical Nuclear Medicine (2014)

The aim of this study was to establish the novel automatic method to quantify blood flow volumes of the major intracranial arteries by using SPECT.We created the vascular templates to cover the territory supplied by the major intracranial arteries. Each blood flow volume was calculated as the regional cerebral blood flow on SPECT using this template × volume size of the template. In this study, we evaluated the volume flows in 22 cerebral hemispheres with normal perfusion and 28 hemispheres with severe stenosis in the internal cerebral artery (ICA) or middle cerebral artery (MCA) and that at acetazolamide test in 16 normal hemispheres and 20 hemispheres with stenosis.The mean blood flow volumes of the ICA and MCA in the normal hemispheres increased to more than 40% after acetazolamide test (161-228 mL/min for ICA and 111-157 mL/min for MCA), although those in the hemispheres with stenosis increased to less than 35% (158-192 mL/min for ICA and 107-127 mL/min for MCA). The receiver operating characteristic analyses revealed that the simple difference between the blood flow volume at acetazolamide test and that at rest using the new MCA template was superior to detecting reduction of cerebrovascular reactivity (CVR), compared with the conventional percent CVR using the original template.Blood flow volumes of the intracranial arteries had been able to be quantified automatically on SPECT, and difference of CVR was available for predicting the blood demand-supply balance.
Oral immunotherapy with low allergenic hydrolysed egg in egg allergic children
Authors: S. Giavi, Y. M. Vissers, A. Muraro, R. Lauener, A. P. Konstantinopoulos, A. Mercenier, A. Wermeille, F. Lazzarotto, R. Frei, R. Bonaguro, S. Summermatter, S. Nutten, N. G. Papadopoulos
Journal: Allergy (2016)

A major drawback of oral immunotherapy for food allergy is the possibility of severe side-effects. We assessed both safety and efficacy of a low allergenic hydrolysed egg (HydE) preparation used in a double-blind placebo-controlled randomized study in egg allergic children.In a pilot multicentre study, 29 egg allergic patients (aged 1-5.5 years) were administered daily for 6 months 9 g HydE or placebo in a blinded, randomized manner. Safety was verified by oral food challenge to assess tolerance towards HydE at the start and efficacy by an open oral food challenge (OFC, primary outcome) at the end. Additionally, changes in basophil activation and specific IgE and IgG4 were assessed.All egg allergic patients randomized to HydE (n = 15) tolerated the full dose at day 1 and received the maintenance dose from the start at home. No statistically significant difference was observed on the final OFC (36% and 21% had a negative OFC in the treatment and placebo groups, respectively). Specific IgG4 levels increased, while both CD203c+ and CD63+ basophils decreased significantly more over time in the treatment than in the placebo group.HydE can be regarded as a safe, low allergenic product to use in children allergic to egg. Although not significant, HydE given for 6 months increased numerically the proportion of patients becoming tolerant to egg. HydE induced a modulation of the immune response towards better tolerance. A longer treatment period and/or a higher dose may improve the clinical outcome and should be evaluated.
Angiotensin II Receptor Blocker (ARB) May Have a Synergic Effect in Metastatic Colorectal Cancer (MCRC) Patients Treated with Bevacizumab (BEV)
Authors: Hiroki Osumi, Satoshi Matsusaka, Mitsukuni Suenaga, Takeru Wakatsuki, Yosuke Kumekawa, Mariko Ogura, Masato Ozaka, Eiji Shinozaki, Keisho Chin, Nobuyuki Mizunuma
Journal: Annals of Oncology (2013)
OP0162 Degenerative Changes of the Spine on MRI in Patients with Inflammatory Back Pain from the DESIR Cohort:
Authors: F. De Bruin, M. Treyvaud, A. Feydy, J. Bloem, M. Dougados, L. Gossec, D. van der Heijde, M. Reijnierse
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Magnetic Resonance imaging (MRI) is a sensitive method to detect early signs of axial spondyloarthritis (axSpA). A positive MRI of the Sacroiliac joints is part of the imaging arm of the ASAS criteria. However, the exact role of MRI of the spine in screening for axSpA needs to be determined. Degenerative changes (DCs) are a common finding in the spine of adults; they might be an alternative explanation for complaints and might interfere with diagnostic decision making <h3>Objectives</h3> To describe the prevalence of degenerative changes on spine MRI in axSpA and no axSpA patients in the DESIR cohort <h3>Methods</h3> The DESIR cohort is a prospective longitudinal cohort study of adults aged 18-50 with inflammatory back pain (IBP) ≥3 months, ≤3 years. Patients (pts) were categorized as axSpA or no axSpA, based on the ASAS criteria for axial spondyloarthritis. Baseline 1.5T MRI (sagittal T1TSE and STIR) of the spine were scored independently by two readers, blinded for clinical information, for: degree of disc degeneration (DD) (Pfirrmann 5 point scale, class ≤2 considered normal), endplate changes (Modic 3 point scale) and presence of a high intensity zone (HIZ), disc protrusion or extrusion, canal stenosis, spondylolisthesis, facet joint osteoarthritis (FJOA) and Schmorls nodes (±edema). In case of disagreement, a third reader acted as adjudicator. AxSpA and no axSpA pts were compared using chi2 test, regression analysis was used for association between age and DCs <h3>Results</h3> 648 pts (303 male, 47%) with mean age 34 (±9) had a MRI spine available and were evaluated. Of these, 454 (70%) had axSpA. 456 pts (70%) showed one or more DCs (mean 3.4 (±4.3), range 1-39). In 366 (57%) pts, DCs were observed in the lumbar spine and in 292 (45%) pts in L4-L5 and L5-S1. Less pts had DCs in the cervical spine (119, 18%), and thoracic spine (253, 39%). DD and Schmorls nodes were most prevalent (table 1). Modic type 3 was not observed. Table 1 lists the number of pts with none, one or multiple changes. 192 (30%) pts with no DCs were evenly distributed between the axSpA and no axSpA groups (56/194, 29% and 136/456, 30%) (P=0.854). With increasing age, the total number of DCs increased (b=0.11 and P&lt;0.001) and this was also for canal stenosis, extrusion, HIZ, FJOA, Modic I and Pfirrmann (b=0.002 to 0.058 and <i>P</i>=0.047 to &lt;0.001). <h3>Conclusions</h3> Prevalence of DCs is high in pts with IBP in the DESIR cohort and in accordance with literature. Most DCs are found in the (lower) lumbar spine. With age, the prevalence of DCs increased. No difference was found between axSpA and no axSpA pts. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2246
Hispanic Community Boosted By Outreach Grant
Authors: N. Castro
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Hispanic Community Boosted By Outreach Grant Get access Nelvis Castro Nelvis Castro Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 22, 17 November 1993, Page 1804, https://doi.org/10.1093/jnci/85.22.1804 Published: 17 November 1993
Final Results of a Multicenter Phase II Trial with Translational Elements to Investigate the Possible Infective Causes of Ocular Adnexal Marginal Zone B-Cell Lymphoma (OAMZL) with Particular Reference to Chlamydia Species and the Efficacy of Doxycycline As First-Line Lymphoma Treatment (the IELSG#27 TRIAL)
Authors: Silvia Govi, Riccardo Dolcetti, Maurilio Ponzoni, Elisa Pasini, Silvia Mappa, Marta Bruno Ventre, Claudio Doglioni, Francesco Bertoni, Francesco Zaja, Carlos Montalban, Caterina Stelitano, Maria Elena Cabrera, Franco Cavalli, Emanuele Zucca, Andrés J.M. Ferreri
Journal: Blood (2011)
Occurrence of Hematopoietic Neoplasms in Virginia Oysters (Crassostrea virginica)
Authors: E. Michael Frierman, J.D. Andrews
Journal: JNCI Journal of the National Cancer Institute (1976)

A neoplastic disease of the hematopoietic system of oysters was found in tray-cultured native and laboratorybred populations and was associated with mortalities during field monitoring. The disease, characterized by nuclear abnormalities and intensive proliferation of hemocytes, was first observed at the Virginia Institute of Marine Science in 1963. Cases rarely occurred during 14 years (1959–1973 inclusive) of regular sampling and monitoring of thousands of oysters. However, two groups exhibited a high susceptibility to this disease in a program of intensive inbreeding to achieve genetic resistance to oyster pathogens.
Abstract 2038: miR-149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells
Authors: Ruey-Jen Lin, You-Chin Lin, Alice L. Yu
Journal: Cancer Research (2010)

Abstract microRNAs (miRNAs) play vital roles in several biological processes, including apoptosis, by negatively regulating the expression of target genes. The molecular mechanisms of the key survival signal, Akt family, have been extensively investigated, but whether is regulated by miRNA remains unknown. In a recent study of neuroblastoma samples, we found the expression of miR-149 to be lower in the high-risk group than the low- and intermediate-risk groups. Upon transfection of Be2C, a neuroblastoma cell line and HeLa cells with miR-149 oligo, no changes in cell growth were observed. On the other hand, ectopic expression of miR-149*, the cognate miRNA of miR-149, inhibited the growth and induced apoptosis in these two cancer cell lines. By TargetScan screening, Akt1, the predominant Akt isoform in most tissue, E2F1, and b-Myb were predicted as possible target genes of miR-149*. In Be2C and HeLa cells transfected with miR-149* oligo, reduced expressions of Akt1, E2F1, and b-Myb at protein level were detected by Western blotting, and decreased mRNA levels of Akt1 and E2F1 were also noted by RT-qPCR. Using luciferase reporter assay, the target sites were verified in the 3′UTRs of Akt1 and E2F1, but not in b-Myb, suggesting that Akt1 and E2F1 were the direct target and b-Myb was an indirect target of miR-149*. Silencing of Akt1 or E2F1 expression also led to similar apoptotic changes as miR-149* transfection in these two cell lines, suggesting that the pro-apoptotic effects of miR-149* was exerted at least in part by repressing Akt1 and E2F1 expressions. Importantly, analysis of primary neuroblastoma samples (n=56) revealed a significant inverse correlation of miR-149* with E2F1 expressions (p=0.026). Furthermore in stage1 samples, the mean expression level of miR-149* was significantly higher than in stage 2/3 (p&amp;lt;0.05), and that of E2F1 appeared to be lower. The results provide further support of an important role of miiR-149* in regulation of E2F1, especially in stage1 neuroblastoma tumors. Interestingly, using the reporter assays, excess miR-149 introduced by transfection to simulated its preponderance in the in vivo condition, could not overcome the repressive function of miR-149* on the target genes. This implies that the pro-apoptotic function of miR-149* may not be dampened by its predominant cognate, miR-149, in vivo. Our findings not only provided the first evidence that Akt1 is a direct target of a miRNA but also demonstrated that miR-149* is a pro-apoptotic miRNA by repressing the expression of Akt1 and E2F1. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2038.
Endoscopic management of an esophagopleural fistula resulting from a gunshot wound
Authors: Shashank Garg, Mark Katlic, Sudhir Dutta
Journal: Endoscopy (2014)

A 36-year-old man presented to the emergency department with a gunshot injury to his neck. He was intubated and taken to the operating room. As his neck was being dissected, an air leak in the trachea, indicative of a direct injury from the gunshot wound, was detected. This was repaired successfully. No damage to the esophagus was seen during an intraoperative esophagoscopy.
Abstract 4190: Ezrin plays a key role in the regulation of translation in metastatic osteosarcoma
Authors: James J. Morrow, Joseph Briggs, Ling Ren, Kristi Chakrabarti, Jessica Cassavaugh, Timothy D. Veenstra, Qingrong Chen, Javed Khan, Aykut Uren, Chand Khanna
Journal: Cancer Research (2012)

Abstract Our previous studies have demonstrated the association between Ezrin and the metastatic biology of pediatric sarcomas including osteosarcoma (OS) and rhabdomyosarcoma. Mechanistic studies exploring this association have shown that Ezrin expression enhances the survival of metastatic cells upon their arrival to the secondary metastatic site. In order to better understand this role in metastasis, we undertook two non-candidate analyses of Ezrin function including a microarray subtraction of high and low Ezrin expressing cells and a proteomic approach to identify proteins that bind the N-terminus of Ezrin in tumor lysates. Functional analyses of these data led to a novel and unifying hypothesis that Ezrin contributes to the efficiency of metastasis through regulation of protein translation. In support of this hypothesis we found Ezrin to be part of a ribonucleoprotein complex and to bind with poly A binding protein 1 (PABA1; PABPC1). Using luciferase reporter-based assays, we have shown that OS cells expressing high levels of Ezrin are able to translate mRNAs containing a stem loop 5′ UTR structure, so called “weakly translated mRNAs,” more efficiently than low Ezrin OS cells. This finding suggests that Ezrin's contribution to the metastatic phenotype may be due in part to enhanced translation of specific mRNAs during metastasis that are normally expressed at low levels outside of the metastatic context. Ongoing studies will now assess the ability of Ezrin to enhance the expression of specific mRNAs in 3-dimensional contexts more relevant to cancer cell growth in vivo. We have developed stable high and low Ezrin osteosarcoma cell lines that express a GFP reporter with or without a complex 5′ UTR stem loop structure in the mRNA transcript and with and without protein destabilizing elements. Initial studies have shown that the addition of the 5′ UTR structure and destabilizing elements progressively limits GFP reporter expression. We plan to confirm that this reduction in expression is due to reduced translation and to assess whether 3-D culture conditions or the in vivo environment enhance expression of these tunable reporters of translation in an Ezrin-dependant manner. We expect these results to provide a novel mechanistic basis to consider how Ezrin may contribute to metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4190. doi:1538-7445.AM2012-4190
The e19a2 BCR/ABL fusion transcript with additional chromosomal aberrations on a new case of chronic myeloid leukemia (CML) of mild type
Authors: R Bertorelle, L Bonaldi, E Bianchini, E Ramazzina, A Del Mistro, S Zamboni, L Chieco-Bianchi, R Paolini
Journal: Leukemia (2001)
Anion Exchange Resins in the Treatment of Heartburn during Pregnancy
Authors: S. Charles Kasdon
Journal: New England Journal of Medicine (1948)

HEARTBURN during pregnancy, an annoying symptom with little if any significance in mortality or serious morbidity statistics, is nevertheless distressing to the patient who suffers from it and to the physician who bears the brunt of the complaints. Rodway and Shelley1 reported this symptom in 66 out of 100 pregnant women, and the experience of most obstetricians tends to corroborate this incidence. The modern theory for the etiology of heartburn states that the regurgitation of gastric contents into the distal esophagus distends the sensitive neural endings of the esophagus. The distention is further enhanced by intermittent spasm of the cardiac . . .
Rheumatoid Pulmonary Disease
Authors: F. Joseph Flatley
Journal: New England Journal of Medicine (1959)

SYSTEMIC granulomatous lesions that have a microscopical appearance similar to that of subcutaneous rheumatoid nodules have been observed in patients with rheumatoid arthritis.1 2 3 4 In the absence of pneumoconiosis such lesions of the lung are believed to be rare. In 1948 Ellman and Ball5 first described 3 patients with rheumatoid arthritis and associated pulmonary disease that they considered a manifestation of the rheumatoid process. Fifty-five cases of rheumatoid pulmonary disease have thus far been reported. In 28 cases the diagnosis was made only on clinical grounds.6 7 8 9 10 11 12 13 14 15 16 17 Of the 27 cases studied histologically, sixteen showed nonspecific changes with diffuse pulmonary fibrosis.4 , 5 , 17 18 19 20 21 22 23 24 Rheumatoid . . .
Hypercalcemia in Hodgkin's Disease
Authors: Bernard Kabakow, Martin F. Mines, Frederick H. King
Journal: New England Journal of Medicine (1957)

BONE involvement in Hodgkin's disease is not uncommon. Variation in the frequency of this complication apparently is dependent upon the thoroughness of the autopsy examination. Clinically and roentgenologically, bony lesions have been reported in 0 to 26 per cent of the cases.1 2 3 4 5 6 7 On pathological examination involvement of the skeletal system is more frequent — 30 to 78 per cent.1 2 3 , 5 , 11 Steiner5 concludes that if extensive examination of the red marrow is made in patients succumbing to this disease, evidence of bone involvement would be found in every case. Because of the infrequency of destruction of the bony cortex, x-ray diagnosis is . . .
Abstract 1868: Sep15 knockout in mice provides protection against chemically-induced aberrant crypt formation
Authors: Petra A. Tsuji, Bradley A. Carlson, Min-Hyuk Yoo, Xue-Ming Xu, Salvador Naranjo-Suarez, Dmitri Fomenko, Vadim N. Gladyshev, Dolph L. Hatfield, Cindy D. Davis
Journal: Cancer Research (2011)

Abstract The essential nutrient selenium appears to have cancer preventive properties that are partly mediated through selenoproteins. This study investigated the role of the 15 kDa selenoprotein (Sep15) in cancer by examining Sep15 knockout in mice. Weanling homozygous Sep15 knockout, heterozygote and wild type littermate controls (N=12/genotype) were given four weekly subcutaneous injections of the known colon carcinogen azoxymethane (10 mg/kg). Sep15 knockout mice developed significantly (p&amp;lt;0.001) fewer aberrant crypt foci (ACF) than controls. Dietary selenium (0, 0.1 or 2.0 μg selenium/g diet) did not significantly affect ACF formation in Sep15 knockout mice. To investigate molecular targets affected by Sep15 knockout, gene expression patterns in colonic mucosal cells of knockout and wild type mice were compared with microarrays and Ingenuity Pathway Analysis. Quantitative PCR and western blot analysis revealed guanylate binding protein-1 (GBP1) mRNA and protein expression to be strongly upregulated in Sep15 knockout mice. Furthermore, serum analysis indicated significant differences in cytokine expression in Sep15 knockout mice. Our results suggest that Sep15 knockout mice are protected against chemically-induced ACF formation possibly through alterations in inflammatory pathways. Funded by NCI Intramural support, the Cancer Prevention Fellowship Program, NIH grants and the Division of Cancer Prevention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1868. doi:10.1158/1538-7445.AM2011-1868
Bacteremia Due to<i>Serratia marcescens</i>
Authors: James N. Wilfert, Fred F. Barrett, Edward H. Kass
Journal: New England Journal of Medicine (1968)

In 39 episodes of bacteremia due to Serratia marcescens in 38 patients the immediate mortality was 36 per cent. Factors associated with serratia infection included previous antimicrobial therapy and underlying chronic debilitating disease. All but two of the infections were hospital acquired. Indwelling intravenous or intraperitoneal catheters and the previously instrumented urinary tract were the most frequent portals of entry. The strains isolated were nonpigmented and resistant to most antimicrobial agents, but most frequently sensitive to gentamicin or to a combination of chloramphenicol and kanamycin.
Gemtuzumab ozogamicin (GO)-associated veno-occlusive disease (VOD): An analysis of adverse drug reaction (ADR) reports in the clinical trials, clinical practice, and in the medical literature
Authors: S. A. Klinge, R. Chacko, C. L. Bennett, S. Luminari, E. A. Lyons, S. Trifilio, J. McKoy, P. R. Yarnold, D. W. Raisch, M. S. Tallman
Journal: Journal of Clinical Oncology (2004)

6616 Background: The incidence of GO-associated VOD and predisposing factors are uncertain. Barriers to understanding this toxicity are under- and incomplete ADR reporting. This concern is especially important for drugs such as GO, which receive accelerated FDA approval. Methods: We evaluated the completeness of GO-associated VOD ADR cases reported to the in the context of clinical trials (n=39) and non-clinical trial settings (n= 54), and reviewed incidence rates and predisposing factors reported in the medical literature. Results: clinical trial cases contained more information on abdominal examination findings (90% vs 59%), GO dose (92% vs 63%), GO schedule (92% vs 63%), VOD onset date (85% vs 51%), hepatic transaminases levels (72% vs 39%) and bilirubin (82% vs 57%) (p's<0.05). ADR reports indicated that GO-associated VOD was characterized by: elevated hepatic enzymes (82%), bilirubin (88%) and weight gain, ascites, or painful hepatomegaly (88%) occurring at a median of 10 days after GO administration (IQR 7.5–20). The medical literature was reviewed for incidence rates when GO was administered in both FDA-approved and “off-label” regimens, such as with hematopoietic stem cell transplantation (HSCT): Conclusions: 1) ADR reporting is more complete in the clinical trial versus the non-clinical trial setting; 2) VOD is a serious ADR that occurs at low rates when GO mono-therapy is used at the FDA approved dose and schedule and at higher rates when GO is administered at non-FDA approved doses or schedules, concurrently with other chemotherapeutic agents or when allogeneic HSCT is performed close to the time of GO administration; and 3) for cancer drugs such as GO which receive accelerated approval from the FDA, consideration should be given to mandating prospective post-marketing safety registries. No significant financial relationships to disclose.
A memorable patient
Authors: Richard Harding
Journal: BMJ (1999)

uptake would have been greater.For example, general practitioners overrode a decision to start warfarin in 18 out of 44 patients who were willing to take it after being advised by a doctor involved in a research project. 2 But the approach reported here suggests that a patient centred method, in which as many patients as possible are given an active role in deciding their treatment, produces a less successful outcome regarding warfarin uptake but perhaps a better one regarding the ethics of patient management.It might seem ironic that it is patients who represent an important impediment to implementation of effective treatment given that they apparently have most to benefit, but without their sup-port evidence based medicine is likely to have only limited applicability in general practice.We thank Mr Chris Byrne for performing the echocardiography.