tbuckley/cabot-search huggingface dataset:
AB0486 High frequency ultrasound and laser doppler flowmetry for the evaluation of digital dermal thickness and fingertip blood perfusion in systemic sclerosis patients
Authors: A. Sulli, B. Ruaro, E. Alessandri, F. Ravera, M. A. Cimmino, G. Zampogna, M. Cutolo
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Modified Rodnan skin score (mRss) and high frequency ultrasound (US) are employed to evaluate dermal thickness (DT) in systemic sclerosis (SSc) patients (1-3). Laser Doppler flowmetry (LDF) is used to assess and measure the peripheral blood perfusion (4). <h3>Objectives</h3> The aim of this study was to identify possible correlations between finger dermal thickness (DT) using both US and mRss, and fingertip blood perfusion (FBP) in SSc patients. <h3>Methods</h3> Forty-nine consecutive SSc patients and 37 healthy subjects (CNT) were enrolled, after informed consent. US was performed in both SSc patients and CNT to evaluate DT (ultrasound-DT) at the level of the dorsum of the middle phalanx of the third finger on both right and left hand, and the average value was recorded in millimetres. After double blind evaluation of US pictures, the intra-operator reproducibility in measuring DT was found of 95%. DT was also assessed by mRss in SSc patients at the level of the dorsum of the fingers bilaterally, and the average score of the fingers was calculated. LDF was performed in both SSc patients and CNT. FBP was detected at the level of the fingertips bilaterally, and the results were expressed as perfusion units (PU). The same operator (BR) performed the examination, and there was a 88% reproducibility of the LDF assessment. Statistical analysis was carried out by non parametric tests. <h3>Results</h3> SSc patients showed higher ultrasound-DT as well as lower FBP at the level of the fingers, than healthy subjects (p&lt;0.0001). A negative correlation was observed between FBP and both ultrasound-DT (r=-0.36, p=0.02) and mRss values (r=-0.41, p=0.002). A positive statistically significant correlation was observed between left and right finger ultrasound-DT (r=0.68, p&lt;0.0001), as well as between ultrasound-DT and mRss (r=0.55, p&lt;0.0001). <h3>Conclusions</h3> A significant negative correlation between finger DT, evaluated by either US or mRss, and FBP, evaluated by LDF, is detectable with reliability in SSc patients. <h3>References</h3> Clements PJ, et al. J Rheumatol 1993; 20: 1892-6. Moore TL, et al. Rheumatology 2003; 42: 1559-63. Kaloudi O et al. Ann Rheum Dis. 2010; 69:1140-3. Cutolo M, et al. J Rheumatol 2010; 37:1174-80. <h3>Disclosure of Interest</h3> None Declared
Native Americans Misrepresented in Cancer Data Bases
Authors: S. Jenks
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Native Americans Misrepresented in Cancer Data Bases Get access Susan Jenks Susan Jenks Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Page 1476, https://doi.org/10.1093/jnci/84.19.1476 Published: 07 October 1992
P1097 LONG-TERM SAFETY AND EFFICACY OF MIRAVIRSEN IN CHRONIC HEPATITIS C PATIENTS
Authors: M.H. van der Ree, A.J. van der Meer, J. de Bruijne, A. van Vliet, T.M. Welzel, E.J. Lawitz, M. Rodrigues-Torres, V. Kupcova, A. Wiercinska-Drapalo, M.R. Hodges, H.L.A. Janssen, H.W. Reesink
Journal: Journal of Hepatology (2014)
ESTUDIO PRELIMINAR DE LA CARDIOMIOTOMIA ENDOLUMINAL DE TODA LA PARED COMO ALTERNATIVA AL POEM EN EL TRATAMIENTO DE LA ACHALASIA
Authors: MD Castillo Cejas, J Dot Bach, M Abu-Suboh, J Armengol Bertroli, M Masachs Peracaula, A Benages Curell, JC Salord Osas, M Estevez, C Fonseca, S Kantsevoy, JR Armengol Miró
Journal: Endoscopy (2013)

Introducción: Las opciones terapeuticas de la acalasia incluyen tratamiento médico, tratamientos endoscópicos y opciones quirúrgicas. Recientemente se ha descrito una técnica mediante NOTES (Miotomia Peroral, POEM), que ofrece resultados prometedores. En este estudio presentamos una variante de la técnica POEM, más sencilla técnicamente i más rápida. Objetivo: Valorar una nueva técnica de miotomia endoscópica. Material y Método: Se realiza estudio prospectivo, controlado y aleatorizado, en modelo porcino, realizándose miotomia mediante corte longitudinal de la totalidad de la pared esofágica des del cardias gástrico hasta 2 cm por encima del cardias esofágico. A partir de este momento los animales se aleatorizaban en tres grupos para el cierre del orificio: cierre con clip Aponos, cierre con hemoclips, o cierre con sistema de sutura endoscópica quirúrgica. Se realizó manometria del EEI previa, durante y después de la intervención, así como control manométrico a la semana. Se realizó control al mes y los animales fueron eutenasiados al mes con estudio necropsico. Resultados: Se incluyeron 30 animales (10 en cada grupo). El tiempo medio de intervención fue de 18 min para el grupo de cierre con clips, 25 min para el grupo de hemoclips y 45 minutos para el grupo de sutura quirúrgica. Uno de los animales del grupo de Aponos falleció intraoperatomente. En el control a la semana todos los animales presentaban buena cicatrización, observando 2 casos de cierre atípico con granuloma de paret en el grupo de hemoclips. El resto fueron sacrificados al més, excepto dos que fallecieron antes debido a complicaciones derivadas de la intervención. Conclusiones: Esta nueva técnica de miotomia endoscópica peroral, sin necesidad de tunelización, ofrece la ventaja de ser más rápida y técnicamente más sencilla que la técnica POEM. El cierre mediante clip aponos, es significativamente más rápido, pero el cierre mediante sutura quirúrgica es más seguro.
P885 RECIPIENT AND DONOR GENDER MATCH PREDICTS THE OUTCOME OF ANTIVIRAL THERAPY FOR RECURRENT HEPATITIS C
Authors: D. Bitetto, S. Pecere, L. Pasulo, L. Belli, R.M. Iemmolo, M.C. Morelli, F. Donato, P. Burra, M. Rendina, F.R. Ponziani, L. Miglioresi, D. Di Paolo, M. Merli, A. Gasbarrini, P. Toniutto, S. Fagiuoli
Journal: Journal of Hepatology (2014)
S20 The bacterial cytoskeleton--a new antimicrobial target in cystic fibrosis pathogens?
Authors: S. C. Carnell, J. D. Perry, C. M. A. Khan, A. De Soyza
Journal: Thorax (2010)

<h3>Background</h3> <i>Burkholderia cepacia</i> complex (BCC) bacteria are opportunistic pathogens which cause severe lung infections in cystic fibrosis (CF) patients. Treatment of BCC infections is difficult due to the inherent multidrug resistance of BCC. There is a pressing need to find new bacterial targets for antimicrobials that provide functions essential for cell growth &amp; replication. A major component of the bacterial cytoskeleton is the actin homologue MreB. MreB maintains bacterial cell shape by forming filaments under the bacterial inner membrane. A22 is a cell permeable compound that disrupts MreB, destabilising the bacterial cytoskeleton and altering the bacterial shape. <h3>Aims</h3> To investigate the MreB bacterial cytoskeleton as a novel target for antimicrobials. <h3>Methods</h3> We have tested a synthetic library of A22-related compounds and identified compound Q22 as a potential antimicrobial of interest against BCC and <i>Pseudomonas aeruginosa</i> strains. BCC bacteria have been grown in the presence of Q22 and a number of phenotypic changes observed. <h3>Results</h3> Q22 inhibited growth of all 9 BCC species tested, including <i>B. cenocepacia</i>. A reduction in growth rate and cell morphology changes were also observed (Abstract S20 Figure 1). Higher concentrations of Q22 were required to exert <i>B. cenocepacia</i> growth effects (30 μg/ml Q22) when compared to <i>P. aeruginosa</i> (3 μg/ml Q22), probably due to the presence of two <i>mreB</i> genes in the <i>B. cenocepacia</i> genome. BCC bacteria lipopolysaccharide (LPS) is known to play an important role during infection. We analysed the LPS profile of BCC bacteria grown in the presence of Q22 and selected strains show profile differences when compared to untreated bacteria. The influence of Q22 treatment on bacterial motility and Type 3 secretion, a virulence associated secretion system, was assessed. However, growth inhibition masked motility analysis and differences observed in secreted protein profiles could not be attributed to Type 3 secretion. The growth conditions required for induction of Type 3 secretion <i>in vitro</i> remain undefined. <h3>Conclusion</h3> <i>In vitro</i> MreB is an attractive new target for novel antimicrobials. Further analysis of current observations and additional phenotypic analysis will be required to dissect the nature of Q22-induced changes. Work supported by Newcastle-Upon-Tyne Hospitals Special Trustees and Italian CF Research Foundation (FFC).
Occult Intracranial Aneurysms in Polycystic Kidney Disease
Authors: Andrew S. Levey, Stephen G. Pauker, Jerome P. Kassirer
Journal: New England Journal of Medicine (1983)

Patients with polycystic kidney disease are at increased risk of subarachnoid hemorrhage from rupture of intracranial aneurysms. We used decision analysis to assess whether or not patients with polycystic kidney disease should undergo routine cerebral arteriography for intracranial aneurysms and prophylactic surgery, if an aneurysm is detected. We incorporated published data on the prevalence of intracranial aneurysms in patients with polycystic kidney disease, the annual rate of aneurysmal rupture, the risk of grave complications of rupture, and the likelihood of grave complications of arteriography and prophylactic surgery. Outcomes were assessed as years of survival, and benefit was calculated as the gain in survival. Our analysis shows that arteriography should not be carried out routinely because its benefit exceeds one year only if the prevalence of aneurysm exceeds 30 per cent, if the surgical complication rate is 1 per cent or less, and if the patient is under 25 years of age. If newer noninvasive tests, such as digital-subtraction angiography, prove to identify reliably patients who are highly likely to have a cerebral aneurysm, routine screening with these tests will be warranted in patients with polycystic kidney disease. (N Engl J Med 1983; 308:986–94.)
LONG-TERM OUTCOMES OF THROMBUS ASPIRATION DURING PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Ji-Young Yoon, Jeikeon Chae, Sookyeong Song, Lae Young Jung, YISIK KIM, Sun Hwa Lee, Sang-Rok Lee, Kyoung-Suk Rhee, Wonho Kim, Jaeki Ko
Journal: Journal of the American College of Cardiology (2015)
Refractory Subcutaneous Sweet Syndrome Treated With Adalimumab
Authors: Ashwin Agarwal, Willis Barrow, M. Angelica Selim, Matilda W. Nicholas
Journal: JAMA Dermatology (2016)

Report of a Case | The patient first presented in 2008 at age 41 years with a 3-year history of a diffuse asymptomatic ashygray dermatosis.The lesions initially appeared erythematous with nonscaling palpable borders, and within 3 months it had evolved to ashy-gray patches.There were no identifiable triggers or associated family history.Cutaneous examination revealed ashy-gray patches of varying sizes symmetrically distributed throughout the body (Figure ,A), while the mucosa, palms, soles, and nails were spared.Laboratory findings, including complete blood cell count, thyroid function tests, biochemical profiles, urinanalysis, and autoantibody assays, were unremarkable.A biopsy specimen from a lesion on the right upper abdomen showed thinned epidermis, superficial and perivascular lymphocytic infiltrate with linear interface change, and pigment incontinence in the papillary dermis with macrophages.Clinical and histopathological findings were thought to be most consistent with EDP, and the patient, who weighed 78 kg, was subsequently treated with isotretinoin, 20 mg/d.Within the first 4 months of therapy, the dermatosis improved 90%, and no new lesions were noted (Figure ,B).A second lesional biopsy specimen taken 4 months after treatment began, and from a site adjacent to the baseline biopsy, revealed punctate vacuolar degeneration of the basal layer, mild lymphohistiocytic infiltrate, and melanophages in the superficial dermis with sparse pigment incontinence.Isotretinoin treatment was discontinued after clinical improvement.Two months after isotretinoin treatment was stopped, the dermatosis recurred at baseline level, and the patient was restarted on the isotretinoin regimen, 20 mg/d; the lesions faded again.Then the isotretinoin dose was tapered to 10 mg/d.During the subsequent 7 years of follow-up, the patient took isotretinoin, 10 mg/d, intermittently without any adverse effects except for dry face skin.During this time, the eruption recurred once after discontinuation of isotretinoin treatment for a number of months (patient could not recall exact timing) and disappeared again after retreatment with isotretinoin, 10 mg/d.The periodical laboratory tests during the 7 years of follow-up showed normal serum lipid profiles and biochemical profiles.
Combination of Preoperative Ultrasonographic Mapping and Radioguided Occult Lesion Localization in Patients With Locally Recurrent/Persistent Papillary Thyroid Carcinoma
Authors: Seyfettin Ilgan, Erkan Öztürk, Ramazan Yildiz, Özdeş Emer, Asli Ayan, Semih Görgülü, Engin Alagöz, Salih Deveci, Mehmet Ali Özgüven, Turgut Tufan
Journal: Clinical Nuclear Medicine (2010)

Purpose: To improve the surgical success and reduce the complication rates, we combine our routine preoperative ultrasound (US) mapping technique with radioguided occult lesion localization (ROLL) in patients with papillary thyroid cancer recurrences in central compartment. Materials and Methods: In the morning of surgery, biopsy proven recurrent/persistent tumoral lesions were plotted on a sketch and injected with Tc-99m labeled macroaggregated albumin under US guidance. Thyroid bed exploration was carried out based on the location of biopsy proven lesion with the guidance of intraoperative gamma probe and neck map. The lymphoadipose tissues showing high count rates were resected and labeled separately for histopathologic study. Results: Despite extensive scarring in some patients probe safely guided to lesions. Noninjected tumor foci were searched and successfully resected in the light of neck map that showing topographic relation of injected and noninjected lesions. Among total of 41 excised lesions, 28 metastatic foci ranging from 3 to 38 mm in largest diameter were recognized at final histologic examination. Combination of preoperative mapping with ROLL was found helpful by the operating surgeons in all patients, respectively. Except 2 patients with known distant metastases, undetectable thyroglobulin levels were reached 6 weeks after surgery. Conclusions: The use of preoperative US-mapping with ROLL in patients with nonpalpable recurrent/persistent papillary thyroid cancer in central compartment is technically safe and effective method. Combination of techniques provides better information about topographical relations of recurrent/persistent lesions during surgery.
Abstract 3886: Activated insulin-like growth factor (IGF) signaling pathway is a potential therapeutic target for brain metastasis from lung cancer.
Authors: Pei-Fang Wu, Ching-Hung Lin, Wen-Chang Huang, Wen-Chi Feng, Yen-Shen Lu, Chih-Hsin Yang, Ann-Lii Cheng
Journal: Cancer Research (2013)

Abstract Background: Brain metastasis is a formidable challenge in lung cancer treatment. The incidence has been increasing recently because of the advances of treatment which leads to prolonged survival of many patients. Methods: We established xenograft model of brain metastasis. Repeated rounds of in vivo selection and ex vivo primary cultures of the brain metastases resulted in a cell line with a high propensity to metastasize to the brain. Brain-tropism was confirmed by bioluminescence study. Gene expression profiles between parental lung cancer cells (PC9) and brain-tropic cells (PC9-Br) was compared by Agilent Gene Expression Microarray followed by Ingenuity Pathway Analysis. The biologic effects and clinical implications of the candidate molecules were further investigated. Results: Significant activation of IGF and WNT signaling pathways was detected in PC9-Br, as compared with the parental cells. We selected IGF pathway as the first step to explore the potential therapeutic implication. Western blot and RT-PCR validated the results of IGF2 overexpression and activated IGF1R (pIGF1R) in PC9-Br cells. In vitro drug sensitivity tests showed that PC9-Br, in comparison to parental cells, was more resistant to erlotinib, an EGFR TKI (IC50: 30nM for PC9 and 189nM for PC9-Br). Knocking down IGF2 expression in PC9-Br reversed the drug resistance, while adding IGF2 to PC9 enhanced the resistance. In clinical samples, there was a significantly higher expression of pIGF1R in 26 brain metastases as compared to their paired primary lung tumors (mean of H score differences=40.96, 95% C.I.=10.96∼70.96, P=0.0094). Conclusions: IGF signaling pathway is activated in brain-tropic lung cancer cells and could potentially be a therapeutic target for brain metastasis. Acknowledgement: This study was supported by Research Grant 101-M2002 from the National Taiwan University Hospital. Citation Format: Pei-Fang Wu, Ching-Hung Lin, Wen-Chang Huang, Wen-Chi Feng, Yen-Shen Lu, Chih-Hsin Yang, Ann-Lii Cheng. Activated insulin-like growth factor (IGF) signaling pathway is a potential therapeutic target for brain metastasis from lung cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3886. doi:10.1158/1538-7445.AM2013-3886
Arsenic Species in Chicken Breast: Temporal Variations of Metabolites, Elimination Kinetics, and Residual Concentrations
Authors: Qingqing Liu, Hanyong Peng, Xiufen Lu, Martin J. Zuidhof, Xing-Fang Li, X. Chris Le
Journal: Environmental Health Perspectives (2016)

Chicken meat has the highest per capita consumption among all meat types in North America. The practice of feeding 3-nitro-4-hydroxyphenylarsonic acid (Roxarsone, Rox) to chickens lasted for more than 60 years. However, the fate of Rox and arsenic metabolites remaining in chicken are poorly understood.We aimed to determine the elimination of Rox and metabolites from chickens and quantify the remaining arsenic species in chicken meat, providing necessary information for meaningful exposure assessment.We have conducted a 35-day feeding experiment involving 1,600 chickens, of which half were control and the other half were fed a Rox-supplemented diet for the first 28 days and then a Rox-free diet for the final 7 days. We quantified the concentrations of individual arsenic species in the breast meat of 229 chickens.Rox, arsenobetaine, arsenite, monomethylarsonic acid, dimethylarsinic acid, and a new arsenic metabolite, were detected in breast meat from chickens fed Rox. The concentrations of arsenic species, except arsenobetaine, were significantly higher in the Rox-fed than in the control chickens. The half-lives of elimination of these arsenic species were 0.4-1 day. Seven days after termination of Rox feeding, the concentrations of arsenite (3.1 μg/kg), Rox (0.4 μg/kg), and a new arsenic metabolite (0.8 μg/kg) were significantly higher in the Rox-fed chickens than in the control.Feeding of Rox to chickens increased the concentrations of five arsenic species in breast meat. Although most arsenic species were excreted rapidly when the feeding of Rox stopped, arsenic species remaining in the Rox-fed chickens were higher than the background levels.Liu Q, Peng H, Lu X, Zuidhof MJ, Li XF, Le XC. 2016. Arsenic species in chicken breast: temporal variations of metabolites, elimination kinetics, and residual concentrations. Environ Health Perspect 124:1174-1181; http://dx.doi.org/10.1289/ehp.1510530.
Serological Detection of Matrix Metalloproteinase Generated Fragments of Elastin and Type IV Collagen may be Biomarkers of Lung Metastatic Breast Cancer
Authors: N. Willumsen, F. Genovese, C.M. Hogaboam, J.M. Sand, F.J. Martinez, M. Han, H. Skjot-Arkil, M.A. Karsdal, A.C. Bay-Jensen, D.J. Leeming
Journal: Annals of Oncology (2013)
Anticoagulation for Prevention of Thromboembolism Following Fractures of the Hip
Authors: Edwin W. Salzman, William H. Harris, Roman W. DeSanctis
Journal: New England Journal of Medicine (1966)

THROMBOEMBOLISM accounts for much of the morbidity and mortality that follow major trauma. Patients with fractures of the hip are especially prone to the development of venous thromboses, perhaps because they undergo operative procedures in proximity to the veins of the lower extremities followed by a long period of immobilization. Pulmonary embolism is the leading cause of death after fractures of the hip.1 The present controlled study was designed to assess the value of prophylactic anticoagulation with warfarin in the prevention of venous thrombosis and pulmonary embolism in elderly patients with fractures of the hip, a group in whom the . . .
WHICH CLINICAL RISK SCORING METHOD BEST PREDICTS THE PREVALENCE AND PROGNOSIS OF CORONARY ARTERY DISEASE? RESULTS FROM A PROSPECTIVE MULTICENTER INTERNATIONAL STUDY OF 1,096 PATIENTS
Authors: Iksung Cho, Valentina Valenti, Stephan Achenbach, Daniel Berman, Matthew Budoff, Tracy Callister, Hyuk-Jae Chang, Mouaz Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Augustin DeLago, Todd Villines, Martin Hadamitzky, Joerg Hausleiter, Jonathan Leipsic, Leslee Shaw, Philipp Kaufmann, Ricardo Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, James Min
Journal: Journal of the American College of Cardiology (2015)
Complement-Mediated Autoimmune Thrombocytopenia
Authors: Harold A. Lehman, Leorosa O. Lehman, Pradip K. Rustagi, Rajendra N. Rustgi, Richard W. Plunkett, Deborah L. Farolino, James Conway, Gerald L. Logue
Journal: New England Journal of Medicine (1987)

CHRONIC or adult autoimmune thrombocytopenia usually occurs with high levels of platelet-associated IgG antibodies,1 2 3 platelet-associated IgM antibodies,4 5 6 or both. The role of complement-mediated platelet injury in autoimmune thrombocytopenia has not been entirely explained. Most workers have found complement activation to be present,7 8 9 10 11 12 13 14 although some have not.15 16 17 18 Complement activation does have a leading role in certain types of immune thrombocytopenia, such as that due to drugs. In these disorders, severe thrombocytopenia results when complement activation is induced by a reaction of antibody with the drug (e.g., quinine) and platelet membranes.19 In this paper, we describe a patient with apparent chronic autoimmune . . .