tbuckley/cabot-search huggingface dataset:
TCT-90 Efficacy and safety of sequential hybrid therapy with pulmonary endarterectomy and additional balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension
Authors: Kenichi Yanaka, Kazuhiko Nakayama, Toshiro Shinke, Hiromasa Otake, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Yuto Shinkura, Koji Kuroda, Kenzo Uzu, Natsuko Tahara, Yoshinori Nagasawa, Yuichiro Nagano, Naoki Tamada, yoshiro tsukiyama, Hiroyuki Yamamoto, Noriaki Emoto, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2016)
Expression of CD123 (IL-3R-alpha), a Therapeutic Target of SL-401, on Myeloproliferative Neoplasms
Authors: Terra Lasho, Christy Finke, Teresa K. Kimlinger, Darci Zblewski, Dong Chen, Mrinal M. Patnaik, Curtis A. Hanson, Christopher Brooks, Ayalew Tefferi, Animesh Pardanani
Journal: Blood (2014)
Molecular Relapse of Acute Lymphoblastic Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation Can Be Successfully Treated with Donor Lymphocyte Infusions.
Authors: Alida Dominietto, Anna Maria Raiola, Raffaella Grasso, Anna Garuti, Carmen di Grazia, Stefania Bregante, Francesca Gualandi, Adalberto Ibatici, Teresa Lamparelli, Maria Teresa van Lint, Francesco Frassoni, Andrea Bacigalupo
Journal: Blood (2004)
P3.02c-042 IMpower110: Phase III Trial Comparing 1L Atezolizumab with Chemotherapy in PD-L1–Selected Chemotherapy-Naive NSCLC Patients
Authors: Filippo De Marinis, Jacek Jassem, David Spigel, Sivuonthanh Lam, Simonetta Mocci, Alan Sandler, Ariel Lopez-Chavez, Yu Deng, Giuseppe Giacconne, Roy Herbst
Journal: Journal of Thoracic Oncology (2017)
Financial Relationships With Industry Among National Comprehensive Cancer Network Guideline Authors
Authors: Robert W. Carlson, Joan S. McClure
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
TCT-23 Contemporary Trends in Utilization of Mechanical Circulatory Support in Patients Hospitalized After Out-of-Hospital Cardiac Arrest
Authors: Nileshkumar Patel, Nish Patel, Gabriel Hernandez, Shilpkumar Arora, Apurva Badheka, Abhishek Deshmukh, Eduardo DeMarchena, Mauricio Cohen, Carlos Alfonso, Deepak Bhatt, Navin Kapur
Journal: Journal of the American College of Cardiology (2016)
Government yet to see discrimination against UK researchers due to Brexit
Authors: Adrian O’Dowd
Journal: BMJ (2016)

A dedicated inbox that was set up by the government to receive reports of discrimination against UK researchers because of the country’s decision to leave the EU has not been sent any concrete examples, MPs have been told.

Ministers appearing before the House of Commons science and technology committee during an evidence session on 26 October said that they were happy to look at any cases of possible discrimination linked to Brexit.

During the session for the committee’s inquiry into the implications for science and research of leaving the EU, MPs quizzed Jo Johnson, minister …
The Origins of Cognitive Deficits in Victimized Children: Implications for Neuroscientists and Clinicians
Authors: Andrea Danese, Terrie E. Moffitt, Louise Arseneault, Ben A. Bleiberg, Perry B. Dinardo, Stephanie B. Gandelman, Renate Houts, Antony Ambler, Helen L. Fisher, Richie Poulton, Avshalom Caspi
Journal: American Journal of Psychiatry (2016)

Individuals reporting a history of childhood violence victimization have impaired brain function. However, the clinical significance, reproducibility, and causality of these findings are disputed. The authors used data from two large cohort studies to address these research questions directly.The authors tested the association between prospectively collected measures of childhood violence victimization and cognitive functions in childhood, adolescence, and adulthood among 2,232 members of the U.K. E-Risk Study and 1,037 members of the New Zealand Dunedin Study who were followed up from birth until ages 18 and 38 years, respectively. Multiple measures of victimization and cognition were used, and comparisons were made of cognitive scores for twins discordant for victimization.Individuals exposed to childhood victimization had pervasive impairments in clinically relevant cognitive functions, including general intelligence, executive function, processing speed, memory, perceptual reasoning, and verbal comprehension in adolescence and adulthood. However, the observed cognitive deficits in victimized individuals were largely explained by cognitive deficits that predated childhood victimization and by confounding genetic and environmental risks.Findings from two population-representative birth cohorts totaling more than 3,000 individuals and born 20 years and 20,000 km apart suggest that the association between childhood violence victimization and later cognition is largely noncausal, in contrast to conventional interpretations. These findings support the adoption of a more circumspect approach to causal inference in the neuroscience of stress. Clinically, cognitive deficits should be conceptualized as individual risk factors for victimization as well as potential complicating features during treatment.
Infectiousness of HIV-Seropositive Patients with Tuberculosis in a High-Burden African Setting
Authors: Leonardo Martinez, Juliet N. Sekandi, María E. Castellanos, Sarah Zalwango, Christopher C. Whalen
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Policy recommendations on contact investigation of HIV-seropositive patients with tuberculosis have changed several times. Current epidemiologic evidence informing these recommendations is considered low quality, and few large studies investigating the infectiousness of HIV-seropositive and -seronegative index cases have been performed in sub-Saharan Africa.We assessed the infectiousness of HIV-seropositive and -seronegative patients with tuberculosis to their household contacts and examined potential modifiers of this relationship.Adults suffering from their first episode of pulmonary tuberculosis were identified in Kampala, Uganda. Field workers visited index households and enrolled consenting household contacts. Latent tuberculosis infection was measured through tuberculin skin testing, and relative risks were calculated using modified Poisson regression models. Standard assessments of interaction between latent tuberculosis infection, the HIV serostatus of index cases, and other variables were performed.Latent tuberculosis infection was found in 577 of 878 (65.7%) and 717 of 974 (73.6%) household contacts of HIV-seropositive and -seronegative tuberculosis cases (relative risk, 0.89; 95% confidence interval, 0.82-0.97). On further stratification, cavitary lung disease (P < 0.0001 for interaction) and smear status (P = 0.02 for interaction) of tuberculosis cases modified the infectiousness of HIV-seropositive indexes. Cough duration of index cases did not display interaction (P = 0.499 for interaction).This study suggests that HIV-seropositive tuberculosis cases may be less infectious than HIV-seronegative patients only when they are smear-negative or lack cavitary lung disease. These results may explain heterogeneity between prior studies and provide evidence suggesting that tuberculosis contact investigation should include HIV-seropositive index cases in high disease burden settings.
Type I interferon suppresses virus-specific B cell responses by modulating CD8 <sup>+</sup> T cell differentiation
Authors: E. Ashley Moseman, Tuoqi Wu, Juan Carlos de la Torre, Pamela L. Schwartzberg, Dorian B. McGavern
Journal: Science Immunology (2016)

Type I interferon–driven CD8 + T cells suppress neutralizing antibody production during chronic LCMV infection. See related Research Articles by Fallet et al. and Sammicheli et al. and a Focus by Laidlaw et al.
Herd effect from influenza vaccination in non-healthcare settings: a systematic review of randomised controlled trials and observational studies
Authors: Dominik Mertz, Shaza A. Fadel, Po-Po Lam, Dat Tran, Jocelyn A Srigley, Sandra A Asner, Michelle Science, Stefan P Kuster, Johannes Nemeth, Jennie Johnstone, Justin R Ortiz, Mark Loeb
Journal: Eurosurveillance (2016)

Influenza vaccination programmes are assumed to have a herd effect and protect contacts of vaccinated persons from influenza virus infection. We searched MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), Global Health and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to March 2014 for studies assessing the protective effect of influenza vaccination vs no vaccination on influenza virus infections in contacts. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) using a random-effects model. Of 43,082 screened articles, nine randomised controlled trials (RCTs) and four observational studies were eligible. Among the RCTs, no statistically significant herd effect on the occurrence of influenza in contacts could be found (OR: 0.62; 95% CI: 0.34–1.12). The one RCT conducted in a community setting, however, showed a significant effect (OR: 0.39; 95% CI: 0.26–0.57), as did the observational studies (OR: 0.57; 95% CI: 0.43–0.77). We found only a few studies that quantified the herd effect of vaccination, all studies except one were conducted in children, and the overall evidence was graded as low. The evidence is too limited to conclude in what setting(s) a herd effect may or may not be achieved.
TCT-156 Bivalirudin versus Heparin in Primary Percutaneous Coronary Intervention- a Meta analysis
Authors: Mahesh Anantha Narayanan, Yogesh NV. Reddy, Dixitha Anugula, Nagarjuna Gujjula, Apurva Badheka, Abhishek Deshmukh, Manu Kaushik, Ganesh Raveendran
Journal: Journal of the American College of Cardiology (2016)
TCT-374 Propensity Score Matched Analysis of Acute Kidney Injury Following Percutenous Coronary Intervention with Trans-Radial versus Trans-Femoral Approach
Authors: Arie Steinvil, Gilbert Tang, Hector Manel Garcia-Garcia, Toby Rogers, Sarkis Kiramijyan, Edward Koifman, Smita Negi, Sang Yeub Lee, Rebecca Torguson, Augusto Pichard, Lowell Satler, Itshac Itsik Ben-dor, Ron Waksman
Journal: Journal of the American College of Cardiology (2016)
PS01.39: Reach and Adoption of a Surgical Intervention to Improve Pathologic Nodal Staging Across Healthcare Systems within the US Mid-South
Authors: Matthew Smeltzer, Lisa Klesges, Yu-Sheng Lee, Nick Faris, Carrie Fehnel, Cheryl Houston-Harris, Meredith Ray, Edward Robbins, Raymond Osarogiagbon
Journal: Journal of Thoracic Oncology (2016)
TCT-615 Do patients with CKD benefit from Left Atrial Appendage Closure (LAAC) with WATCHMAN? Insights from PROTECT AF
Authors: None Miguel valderrabano, Matthew Price, Vivek Reddy, Maurice Buchbinder, David Holmes, Horst Sievert, Zoltan Turi, Nicole Gordon, Chris Mullin, Peter Sick, Patricia Best
Journal: Journal of the American College of Cardiology (2016)
Cholesterol granuloma of the anterior mediastinum
Authors: Nigel E Drury, Danielle NE Smith, Lucy M Phillips, Simon E Trotter, Maninder S Kalkat
Journal: Thorax (2016)

A 74-year-old man presented with dyspnoea and reduced exercise tolerance (Medical Research Council grade 4). He was a current smoker with a history of paroxysmal atrial fibrillation and COPD for which he was on bronchodilators. There was no history of previous chest trauma or surgery and physical examination was unremarkable. CT thorax showed a 3.2 cm mass in the anterior mediastinum with two foci of coarse calcification (figure 1A). Positron emission tomography (PET)/CT demonstrated significant uptake (maximum standardised uptake ratio of 13.7) in the mass with a central area of inactivity (figure 1B); there was no significant activity elsewhere. His gas transfer was reduced at 63% predicted.



Figure 1 
CT sagittal plane showing a 3.2 cm lesion in the anterior mediastinum with areas of focal …
Ocular adnexal lymphoma subtyped according to the REAL classification: A 12-year experience from a single institution
Authors: J. Herrada, A. F. Campos-Gines, A. Gupta, C. W. Vazquez
Journal: Journal of Clinical Oncology (2007)

18541 Background: The Revised European and American Lymphoma (REAL) classification (1994) provided a useful and practical tool to define lymphomas. The aim is to report our experience with this unusual malignancy diagnosed since the REAL classification was implemented. Methods: Retrospective review was performed on patients (pts) with ocular adnexal lymphoma between 1994 and 2006. Medical records, diagnostic imaging procedures, and pathology reports, including immunophenotyping studies, were reviewed. Histologic definition of lymphoma was based on the REAL Classification. Results: 10 pts were identified. All but one were females. Median age at diagnosis was 69 years (54–84). Primary sites included conjunctiva (5), orbital soft tissue (3), and eyelid (2). No lacrimal gland location was found. Ann Arbor stage at diagnosis was IE in most cases (7). One patient (pt) had stage IIE (conjunctival and maxillary sinus) and 2 pts had simultaneous bone marrow involvement (stage IV). 6 pts had marginal zone B-cell subtype, and the remaining 4 pts had small lymphocytic B-cell lymphoma. Radiation as single treatment modality was given to all 7 pts with stage IE, and all those achieved a complete remission (CR). CR was also achieved using chemotherapy with cyclophosphamide (C), vincristine (V), doxorubicin, prednisone (P), and rituximab followed by radiation in the pt with stage IIE. Of the 2 pts with stage IV, 1 achieved a CR with rituximab-based chemotherapy, and 1 never achieved a CR despite chemotherapy (chlorambucil, CVP). With a median follow-up of 23 months (9–70), the 9 pts that achieved a CR after initial treatment remain alive and disease-free. The only pt that did not achieve a CR lost follow-up at 18 months. Conclusions: In our patient population, radiation alone appears to be an effective treatment modality for stage IE. Achieving a CR seems to be a crucial factor for long-term control of the disease. No significant financial relationships to disclose.
EVALUACIÓN PROSPECTIVA Y CONTROLADA DE LAS CARACTERÍSTICAS TÉCNICAS Y LA EFICACIA DE UN NUEVO ECOENDOSCOPIO DE PUNCIÓN CON VISION ENDOSCÓPICA FRONTAL
Authors: Á Cañete Ruiz, JR Foruny Olcina, F González Panizo, A Caminoa, E Sanz De Villalobos, D Juzgado Lucas, D Boixeda De Miquel, A Albillos Martínez, E Vázquez Sequeiros
Journal: Endoscopy (2016)

Introducción: Los ecoendoscopios (USE) de punción tienen un sistema de visión lateral/oblicua que en ocasiones dificulta el acceso y realización de terapéutica guiada por USE. Para solventar estas limitaciones, Olympus ha desarrollado un nuevo ecoendoscopio de visión endoscópica frontal (FV-CLA), aún en fase de evaluación técnica y clínica.
In‐hospital and 1‐year mortality associated with diabetes in patients with acute heart failure: results from the <scp>ESC‐HFA</scp> Heart Failure Long‐Term Registry
Authors: Giovanni Targher, Marco Dauriz, Cécile Laroche, Pier Luigi Temporelli, Mahmoud Hassanein, Petar M. Seferovic, Jaroslaw Drozdz, Roberto Ferrari, Stephan Anker, Andrew Coats, Gerasimos Filippatos, Maria G. Crespo‐Leiro, Alexandre Mebazaa, Massimo F. Piepoli, Aldo Pietro Maggioni, Luigi Tavazzi
Journal: European Journal of Heart Failure (2016)
Association of Resting Heart Rate and Blood Pressure in Late Adolescence With Subsequent Mental Disorders
Authors: Antti Latvala, Ralf Kuja-Halkola, Christian Rück, Brian M. D’Onofrio, Tomas Jernberg, Catarina Almqvist, David Mataix-Cols, Henrik Larsson, Paul Lichtenstein
Journal: JAMA Psychiatry (2016)

<h3>Importance</h3> Differences in cardiovascular autonomic activity between individuals with psychiatric disorders and healthy controls have been observed, but whether cardiovascular autonomic abnormalities are associated with subsequent psychiatric disorders is unknown. <h3>Objective</h3> To investigate whether differences in cardiac autonomic function as indexed by resting heart rate and blood pressure are associated with psychiatric disorders during the lifetime of men in Sweden. <h3>Design, Setting, and Participants</h3> We conducted a longitudinal register-based study of Swedish men whose resting heart rate (n = 1 039 443) and blood pressure (n = 1 555 979) were measured at military conscription at a mean (SD) age of 18.3 (0.6) years during the period from 1969 to 2010, with register-based follow-up data available until the end of 2013. Analyses were performed from November 18, 2015, to June 9, 2016. <h3>Main Outcomes and Measures</h3> Dates of inpatient/outpatient diagnoses of anxiety disorders, obsessive-compulsive disorder, posttraumatic stress disorder, depressive disorders, bipolar disorder, schizophrenia, and substance use disorders and convictions for violent crimes, between 1973 and 2013, were obtained from nationwide registers. Adjustments were made for height, weight, body mass index, cardiorespiratory fitness, cognitive ability, and socioeconomic covariates. <h3>Results</h3> After adjustment for covariates, Cox regression models with up to 45 years of follow-up data showed that men (mean [SD] age of 18.3 [0.6] years at conscription) with resting heart rates above 82 beats per minute had a 69% (95% CI, 46%-94%) increased risk for obsessive-compulsive disorder, a 21% (95% CI, 11%-33%) increased risk for schizophrenia, and an 18% (95% CI, 13%-22%) increased risk for anxiety disorders compared with men with resting heart rates below 62 beats per minute. Similar associations were observed with systolic/diastolic blood pressure. In contrast, lower resting heart rate and lower systolic blood pressure were associated with substance use disorders and violent criminality. <h3>Conclusions and Relevance</h3> Our results suggest that for men, differences in heart rate and blood pressure in late adolescence are associated with lifetime major psychiatric disorders, with higher levels associated with obsessive-compulsive disorder, schizophrenia, and anxiety disorders and lower levels associated with substance use disorders and violent behavior. Differences in autonomic nervous system functioning may predate or represent an early marker of psychiatric disorders.
Trametinib Drives T-cell–Dependent Control of KRAS-Mutated Tumors by Inhibiting Pathological Myelopoiesis
Authors: Michael J. Allegrezza, Melanie R. Rutkowski, Tom L. Stephen, Nikolaos Svoronos, Alfredo Perales-Puchalt, Jenny M. Nguyen, Kyle K. Payne, Sunil Singhal, Evgeniy B. Eruslanov, Julia Tchou, Jose R. Conejo-Garcia
Journal: Cancer Research (2016)

Abstract Targeted therapies elicit seemingly paradoxical and poorly understood effects on tumor immunity. Here, we show that the MEK inhibitor trametinib abrogates cytokine-driven expansion of monocytic myeloid-derived suppressor cells (mMDSC) from human or mouse myeloid progenitors. MEK inhibition also reduced the production of the mMDSC chemotactic factor osteopontin by tumor cells. Together, these effects reduced mMDSC accumulation in tumor-bearing hosts, limiting the outgrowth of KRas–driven breast tumors, even though trametinib largely failed to directly inhibit tumor cell proliferation. Accordingly, trametinib impeded tumor progression in vivo through a mechanism requiring CD8+ T cells, which was paradoxical given the drug's reported ability to inhibit effector lymphocytes. Confirming our observations, adoptive transfer of tumor-derived mMDSC reversed the ability of trametinib to control tumor growth. Overall, our work showed how the effects of trametinib on immune cells could partly explain its effectiveness, distinct from its activity on tumor cells themselves. More broadly, by providing a more incisive view into how MEK inhibitors may act against tumors, our findings expand their potential uses to generally block mMDSC expansion, which occurs widely in cancers to drive their growth and progression. Cancer Res; 76(21); 6253–65. ©2016 AACR.
P1.48: nab-Paclitaxel + Carboplatin in Advanced Non-Small Cell Lung Cancer: Outcomes in Elderly Patients With Squamous Histology
Authors: Cesare Gridelli, Tianlei Chen, Amy Ko, Teng Jin Ong, Mary O'Brien, Mark Socinski, Pieter Postmus
Journal: Journal of Thoracic Oncology (2016)
National Trends in Hospitalizations for Opioid Poisonings Among Children and Adolescents, 1997 to 2012
Authors: Julie R. Gaither, John M. Leventhal, Sheryl A. Ryan, Deepa R. Camenga
Journal: JAMA Pediatrics (2016)

<h3>Importance</h3> National data show a parallel relationship between recent trends in opioid prescribing practices and hospitalizations for opioid poisonings in adults. No similar estimates exist describing hospitalizations for opioid poisonings in children and adolescents. <h3>Objective</h3> To describe the incidence and characteristics of hospitalizations attributed to opioid poisonings in children and adolescents. <h3>Design, Setting, and Participants</h3> Retrospective analysis of serial cross-sectional data from a nationally representative sample of US pediatric hospital discharge records collected every 3 years from January 1, 1997, through December 31, 2012. The Kids' Inpatient Database was used to identify 13 052 discharge records for patients aged 1 to 19 years who were hospitalized for opioid poisonings. Data were analyzed within the collection time frame. <h3>Main Outcomes and Measures</h3> Poisonings attributed to prescription opioids were identified by codes from the<i>International Classification of Diseases, Ninth Revision, Clinical Modification</i>. In adolescents aged 15 to 19 years, poisonings attributed to heroin were also identified. Census estimates were used to calculate incidence per 100 000 population. The Cochran-Armitage test for trend was used to assess for changes in incidence over time. <h3>Results</h3> From 1997 to 2012, a total of 13 052 (95% CI, 12 500-13 604) hospitalizations for prescription opioid poisonings were identified. The annual incidence of hospitalizations for opioid poisonings per 100 000 children aged 1 to 19 years rose from 1.40 (95% CI, 1.24-1.56) to 3.71 (95% CI, 3.44-3.98), an increase of 165% (<i>P</i>for trend, &lt;.001). Among children 1 to 4 years of age, the incidence increased from 0.86 (95% CI, 0.60-1.12) to 2.62 (95% CI, 2.17-3.08), an increase of 205% (<i>P</i>for trend, &lt;.001). For adolescents aged 15 to 19 years, the incidence increased from 3.69 (95% CI, 3.20-4.17) to 10.17 (95% CI, 9.48-10.85), an increase of 176% (<i>P</i>for trend, &lt;.001). In this age group, poisonings from heroin increased from 0.96 (95% CI, 0.75-1.18) to 2.51 (95% CI, 2.21-2.80), an increase of 161% (<i>P</i>for trend, &lt;.001); poisonings involving methadone increased from 0.10 (95% CI, 0.03-0.16) to 1.05 (95% CI, 0.87-1.23), an increase of 950% (<i>P</i>for trend, &lt;.001). <h3>Conclusions and Relevance</h3> During the course of 16 years, hospitalizations attributed to opioid poisonings rose nearly 2-fold in the pediatric population. Hospitalizations increased across all age groups, yet young children and older adolescents were most vulnerable to the risks of opioid exposure. Mitigating these risks will require comprehensive strategies that target opioid storage, packaging, and misuse.