tbuckley/cabot-search huggingface dataset:
EFFECT OF CHOLESTEROL SYNTHESIS INHIBITION IN NORMOCHOLESTEREMIC YOUNG MEN*
Authors: George L. Curran, Daniel L. Azarnoff, Robert E. Bolinger
Journal: Journal of Clinical Investigation (1959)

Recently the concept of using specific inhibitors of endogenous cholesterol synthesis as a means of reducing the cholesterol content of the body has been reviewed (1).One such specific inhibitor is the metal vanadium.Salts of vanadium have been shown to inhibit the utilization of mevalonic acid for cholesterol biosynthesis (2), to inhibit cholesterol biosynthesis in vitro and in vivo (3), to induce mobilization of predeposited aortic cho- lesterol in rabbits (4) and to lessen the deposi- tion of cholesterol in rabbits (5) and in birds (6) fed high cholesterol diets.To extend these studies to man, the effects of vanadium on sterol balance in normocholestero- lemic men under rigid dietary control were ex- amined.The investigations reported here show that, under such conditions, inhibition of endogenous cholesterol biosynthesis with a salt of vanadium produces a lowering of serum cholesterol levels.The studies provide data which suggest that mobilization of tissue cholesterol stores also occurs. MATERIAL AND METHODSA. Experimental group.The subjects for the study were five normal male medical students, 23 to 26 years of age.The diets were prepared in a separate kitchen and the students ate in a private dining room.During the period of the study a daily weight record of the men showed variations of less than 3 per cent.B. Diet.The diet consisted of an identical daily in- take of the same items divided into three meals plus a
Serum Mir-29a Is Up-Regulated In Acute Graft Versus Host Disease (aGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (allo HSCT) and Activates Dendritic Cells (DCs)
Authors: Yvonne A Efebera, Parvathi Ranganathan, Xueyan Yu, Jessica Hofstetter, Sabrina L Garman, Laura Gibson, William Petros, Michael Craig, Cecelia Fernandez-Cymering, Mehdi Hamadani, Guido Marcucci, Steven M. Devine, Muller Fabbri, Ramiro Garzon
Journal: Blood (2013)
Effect of Pathologic Tumor Response and Nodal Status on Survival in the Medical Research Council Adjuvant Gastric Infusional Chemotherapy Trial
Authors: Elizabeth C. Smyth, Matteo Fassan, David Cunningham, William H. Allum, Alicia F.C. Okines, Andrea Lampis, Jens C. Hahne, Massimo Rugge, Clare Peckitt, Matthew Nankivell, Ruth Langley, Michele Ghidini, Chiara Braconi, Andrew Wotherspoon, Heike I. Grabsch, Nicola Valeri
Journal: Journal of Clinical Oncology (2016)

Purpose The Medical Research Council Adjuvant Gastric Infusional Chemotherapy (MAGIC) trial established perioperative epirubicin, cisplatin, and fluorouracil chemotherapy as a standard of care for patients with resectable esophagogastric cancer. However, identification of patients at risk for relapse remains challenging. We evaluated whether pathologic response and lymph node status after neoadjuvant chemotherapy are prognostic in patients treated in the MAGIC trial. Materials and Methods Pathologic regression was assessed in resection specimens by two independent pathologists using the Mandard tumor regression grading system (TRG). Differences in overall survival (OS) according to TRG were assessed using the Kaplan-Meier method and compared using the log-rank test. Univariate and multivariate analyses using the Cox proportional hazards method established the relationships among TRG, clinical-pathologic variables, and OS. Results Three hundred thirty resection specimens were analyzed. In chemotherapy-treated patients with a TRG of 1 or 2, median OS was not reached, whereas for patients with a TRG of 3, 4, or 5, median OS was 20.47 months. On univariate analysis, high TRG and lymph node metastases were negatively related to survival (Mandard TRG 3, 4, or 5: hazard ratio [HR], 1.94; 95% CI, 1.11 to 3.39; P = .0209; lymph node metastases: HR, 3.63; 95% CI, 1.88 to 7.0; P &lt; .001). On multivariate analysis, only lymph node status was independently predictive of OS (HR, 3.36; 95% CI, 1.70 to 6.63; P &lt; .001). Conclusion Lymph node metastases and not pathologic response to chemotherapy was the only independent predictor of survival after chemotherapy plus resection in the MAGIC trial. Prospective evaluation of whether omitting postoperative chemotherapy and/or switching to a noncross-resistant regimen in patients with lymph node-positive disease whose tumor did not respond to preoperative epirubicin, cisplatin, and fluorouracil may be appropriate.
THE FOREIGN MEDICAL GRADUATE
Authors: J M EMMETT
Journal: JAMA (1960)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HG-72DIPG CELLS ESCAPE THE PONS EARLY DURING TUMOUR EVOLUTION
Authors: Mara Vinci, Anna Burford, Valeria Molinari, Sergey Popov, Kathryn R. Taylor, Elizabeth Y. Qin, Wendy J. Ingram, Andrew S. Moore, Mariona Sunol, Jaume Mora, Carmen de Torres, Ofelia Cruz, Angel M. Carcaboso, Michelle Monje, Alan Mackay, Chris Jones
Journal: Neuro-Oncology (2016)
Irish Physician-Poets
Authors: Kevin M Cahill
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Spontaneous and Induced Tumors in Strain ST Mice2
Authors: Margaret K. Deringer, W. E. Heston, Morris K. Barrett
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Spontaneous and Induced Tumors in Strain ST Mice Get access Margaret K. Deringer, Margaret K. Deringer Search for other works by this author on: Oxford Academic PubMed Google Scholar W. E. Heston, W. E. Heston Search for other works by this author on: Oxford Academic PubMed Google Scholar Morris K. Barrett Morris K. Barrett Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 2, October 1953, Pages 375–380, https://doi.org/10.1093/jnci/14.2.375 Published: 01 October 1953 Article history Received: 26 May 1953 Published: 01 October 1953
Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells
Authors: T Skorski, P Kanakaraj, M Nieborowska-Skorska, MZ Ratajczak, SC Wen, G Zon, AM Gewirtz, B Perussia, B Calabretta
Journal: Blood (1995)
The Secretory and Clinical Aspects of Achlorhydria and Gastric Atrophy as Precursors of Gastric Cancer&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Claude R. Hitchcock, M.D., Ph.D., Lloyd D. MacLean, M.D., W. Albert Sullivan, M.D., M.S.
Journal: JNCI Journal of the National Cancer Institute (1957)

The Secretory and Clinical Aspects of Achlorhydria and Gastric Atrophy as Precursors of Gastric Cancer Get access Claude R. Hitchcock, M.D., Ph.D., Claude R. Hitchcock, M.D., Ph.D. Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Lloyd D. MacLean, M.D., Lloyd D. MacLean, M.D. Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Albert Sullivan, M.D., M.S. W. Albert Sullivan, M.D., M.S. Department of Surgery, University of Minnesota Medical School, Minneapolis, Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 6, June 1957, Pages 795–811, https://doi.org/10.1093/jnci/18.6.795 Published: 01 June 1957 Article history Received: 27 February 1957 Published: 01 June 1957
A systematic investigation of tardive dyskinesia in inpatients
Authors: J M Smith, L T Kucharski, W T Oswald, L J Waterman
Journal: American Journal of Psychiatry (1979)

Although many scales to measure tardive dyskinesia have been developed, none has been widely accepted. The authors used the Abnormal Involuntary Movement Scale (AIMS) to evaluate a group of 293 inpatients who had been given a primary or secondary diagnosis of schizophrenia. They found a tardive dyskinesia prevalence of 30% using a criterion rating of 3 (moderate symptoms) or more on the AIMS. The prevalence figure declined as the criterion became more severe. They also found that women had a much higher prevalence of the disorder only when more severe symptoms were used as the criterion. They conclude that the AIMS is a reliable instrument for assessing tardive dyskinesia.
MB-98ANALYSIS OF A FRIENDLY PANEL FOR MOLECULAR CLASSIFICATION OF MEDULLOBLASTOMA (MB) IN WNT, SHH AND NON-WNT/SHH GROUPS TO CLINICAL PRACTICE AND CLINICAL TRIALS
Authors: Raphael Medeiros, Sidnei Epelman, Filipe Bernei
Journal: Neuro-Oncology (2016)

MB-98. ANALYSIS OF A FRIENDLY PANEL FOR MOLECULAR CLASSIFICATION OF MEDULLOBLASTOMA (MB) IN WNT, SHH AND NON-WNT/SHH GROUPS TO CLINICAL PRACTICE AND CLINICAL TRIALS Raphael Medeiros, Sidnei Epelman, and Filipe Bernei; Department of Paediatric Oncology, Hospital Santa Marcelina, Sao Paulo, SP, Brazil INTRODUCTION: The International MB Working Group suggested an algorithm for molecular classification based primarily on genomic methods. These techniques are laborious, expensive and unreliable on formalin-fixed paraffin embedded (FFPE) tissue. A few recent studies have attempted to classify MBs into three molecular subgroups using pathologist-friendly techniques. OBJECTIVE: Our goal is to validate 9 IHC biomarkers and two FISH probes panels according to recent published results in a Brazilian cohort of pediatric patients. METHODS: We retrospectively retrieved all clinical data of 76 patients from 2005 to 2015. The pathological evaluation was central review, histological classification, IHC panel for beta-catenin, DKK1, GAB1, SFRP1, GLI-1, NPR3, KCNA1, YAP1 and GLI-3 and FISH for c-MYC and N-myc. RESULTS: There was performed IHC and FISH in 46 samples. 21%, 34% and 45% was classified to group Wnt, SHH and non-Wnt/SHH respectively. Classic (89%), desmoplastic/MBEN (50%) and large cell/anaplastic (40%) types belong to Wnt, SHH and non-Wnt/ SHH groups respectively. 52% of patients were alive and 48% was dead of disease progression. 64% got complete response and 38% had recurrence. Molecular classification and recurrence was correlated with OS and PFS. Non-Wnt/SHH, c-MYC positive, large cell/anaplastic type MB and recurrence had dismal outcome. CONCLUSION: Only four IHC markers (betacatenin, YAP1, GAB1 and GLI-3) and c-MYC FISH probe were effective for molecular classification of MB. Large cell/ anaplastic type and c-MYC may predict worse survival and be allocated to more aggressive therapy. These results support to expand the availability of the panel for patients from other institutions in Brazil. Neuro-Oncology 18:iii97–iii122, 2016. doi:10.1093/neuonc/now076.93 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Comparison of self-rated and clinician-rated measures of depression in adolescents
Authors: B N Shain, M Naylor, N Alessi
Journal: American Journal of Psychiatry (1990)

To determine whether patients' self-ratings of depression are comparable to clinicians' ratings, 45 depressed adolescents were administered two self-rated scales and two clinician-rated scales. Correlations of scores tended to be high, with higher correlations for girls than for boys.
Tc-99m DTPA renography in patients with collagen disease.
Authors: M Tezuka, Y Murata, R Ishida, Y Sawada, H Shibuya
Journal: Clinical Nuclear Medicine (2001)

This study evaluated the use of Tc-99m DTPA renography in patients with collagen disease.Tc-99m DTPA renal scintigraphy was performed in 28 patients with clinically diagnosed collagen disease. Twenty-two other patients who underwent renal scintigraphy and were subsequently shown to have no kidney abnormalities served as the control group.One quarter of the patients with collagen disease had abnormal findings of renography, despite the absence of abnormal laboratory data. Renograms were 100% sensitive for the detection of renal disease in patients with collagen disease, and their specificity was 53% when serum blood urea nitrogen, serum creatinine concentration, and proteinuria were the only measures of renal impairment considered. The glomerular filtration rate was not significantly different between the groups, but the bilateral time to peak was significantly greater in the patients with collagen disease. Hydronephrosis was present in 7% of patients with collagen disease.Renography is useful for detecting early changes of renal involvement when the clinical state of collagen disease is evaluated.
Risks of triple negative breast cancer associated with cancer predisposition gene mutations.
Authors: Fergus J. Couch, Margaret Akinhanmi, Hermela Shimelis, Emily J. Hallberg, Chunling Hu, Steven Hart, Raymond Moore, Huong Meeks, Robert Huether, Holly Laduca, Elizabeth Chao, David Goldgar, Jill S Dolinsky
Journal: Journal of Clinical Oncology (2016)

1513 Background: Multigene panel testing for hereditary cancer includes genes identified as hereditary breast and/or ovarian cancer (HBOC) genes despite limited data regarding the precise cancer risks associated with mutations in these genes. Here we report on risks of breast cancer and separately risks of triple negative breast cancer associated with mutations in 20 predisposition genes. Methods: A cohort of 10,091 individuals with breast cancer, including 2,400 with triple negative breast cancer, were tested for mutations with the BreastNext and OvaNext clinical genetic testing panels. A further 2,100 individuals with triple negative breast cancer were tested for the same genes by custom capture-based sequencing. Case-control analyses were performed comparing the frequencies of pathogenic mutations from Caucasian breast cancer cases with frequencies from Caucasian study matched controls, and Caucasian, non-Finnish, non-TCGA controls from the ExAC database. Results: Pathogenic mutations were identified in 9.6% of the BreastNext and OvaNext breast cancer cases. Mutations in the ATM and CHEK2 genes were associated with moderate risks (OR>2) and mutations in PALB2 were associated with high-risks (OR>5) of breast cancer. Pathogenic mutations in MSH6 and RAD51D were associated with moderate risks of breast cancer. Predicted pathogenic missense mutations in CHEK2, MSH2, and MSH6 were associated with moderate risks of breast cancer. In contrast, pathogenic mutations were observed in 13% of 4,500 triple negative breast cancers from the two studies. Mutations in the PALB2, RAD51D, and BARD1 homologous recombination repair (HRR) genes were associated with high risks of triple negative breast cancer, whereas mutations in BRIP1, RAD51C, and NBN were associated with moderate risks. Conclusions: This large breast and ovarian cancer case-control analysis provides useful data for predisposition genes previously lacking risk estimates, that will be useful for clinical risk management of patients. The study of triple negative breast cancer suggests that several HRR genes, previously excluded as moderate or high risk breast cancer genes, all have higher, clinically relevant risks of triple negative breast cancer.
Durability of Addition of Roux-en-Y Gastric Bypass to Lifestyle Intervention and Medical Management in Achieving Primary Treatment Goals for Uncontrolled Type 2 Diabetes in Mild to Moderate Obesity: A Randomized Control Trial
Authors: Sayeed Ikramuddin, Judith Korner, Wei-Jei Lee, John P. Bantle, Avis J. Thomas, John E. Connett, Daniel B. Leslie, William B. Inabnet, Qi Wang, Robert W. Jeffery, Keong Chong, Lee-Ming Chuang, Michael D. Jensen, Adrian Vella, Leaque Ahmed, Kumar Belani, Amy E. Olofson, Heather A. Bainbridge, Charles J. Billington
Journal: Diabetes Care (2016)

OBJECTIVE We compared 3-year achievement of an American Diabetes Association composite treatment goal (HbA1c &amp;lt;7.0%, LDL cholesterol &amp;lt;100 mg/dL, and systolic blood pressure &amp;lt;130 mmHg) after 2 years of intensive lifestyle-medical management intervention, with and without Roux-en-Y gastric bypass, with one additional year of usual care. RESEARCH DESIGN AND METHODS A total of 120 adult participants, with BMI 30.0–39.9 kg/m2 and HbA1c ≥8.0%, were randomized 1:1 to two treatment arms at three clinical sites in the U.S. and one in Taiwan. All patients received the lifestyle-medical management intervention for 24 months; half were randomized to also receive gastric bypass. RESULTS At 36 months, the triple end point goal was met in 9% of lifestyle-medical management patients and 28% of gastric bypass patients (P = 0.01): 10% and 19% lower than at 12 months. Mean (SD) HbA1c values at 3 years were 8.6% (3.5) and 6.7% (2.0) (P &amp;lt; 0.001). No lifestyle-medical management patient had remission of diabetes at 36 months, whereas 17% of gastric bypass patients had full remission and 19% had partial remission. Lifestyle-medical management patients used more medications than gastric bypass patients: mean (SD) 3.8 (3.3) vs. 1.8 (2.4). Percent weight loss was mean (SD) 6.3% (16.1) in lifestyle-medical management vs. 21.0% (14.5) in gastric bypass (P &amp;lt; 0.001). Over 3 years, 24 serious or clinically significant adverse events were observed in lifestyle-medical management vs. 51 with gastric bypass. CONCLUSIONS Gastric bypass is more effective than lifestyle-medical management intervention in achieving diabetes treatment goals, mainly by improved glycemic control. However, the effect of surgery diminishes with time and is associated with more adverse events.
HG-126WHOLE GENOME microRNA PROFILING IN FUNCTIONALLY-VALIDATED INVASIVE GBM CELLS IDENTIFIES A NOVEL SET OF microRNAs DRIVING GBM INVASION
Authors: Lin Qi, Yulun Huang, Hua Mao, Mari Kogiso, Xiumei Zhao, Yuchen Du, Holly Lindsay, Xiaojun Yuan, Patricia Baxter, Jack Su, Chris Man, Laszlo Perlaky, Zhong Wang, You-Xing Zhou, Xiao-Nan Li
Journal: Neuro-Oncology (2016)
Glycogen in the Epidermis of Mice Painted with Methylcholanthrene
Authors: Argyris, Thomas S.
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Glycogen in the Epidermis of Mice Painted with Methylcholanthrene Get access Thomas S. Argyris Thomas S. Argyris Department of Biology, Brown University, Providence, R. I. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1159–1165, https://doi.org/10.1093/jnci/12.6.1159 Published: 01 June 1952 Article history Received: 25 October 1951 Published: 01 June 1952
NICE approves immunotherapy combination for advanced melanoma
Authors: Jacqui Wise
Journal: BMJ (2016)

A combination of two immunotherapy drugs for treating advanced melanoma has been recommended by the National Institute for Health and Care Excellence for use by the NHS in England.

The combination of nivolumab and ipilimumab was fast tracked for appraisal by NICE only a few months after it was licensed. Both drugs boost the activity of the immune system against cancer cells. Trials have shown that the combination can delay progression of advanced (unresectable or metastatic) melanoma by an average of eight months compared with standard treatment.

NICE published …
Phenotypic and molecular characterisation of multiresistant monophasic Salmonella Typhimurium (1,4,[5],12:i:-) in Greece, 2006 to 2011
Authors: G Mandilara, M Lambiri, M Polemis, M Passiotou, A Vatopoulos
Journal: Eurosurveillance (2013)

Recently, multiresistant Salmonella enterica serovar1,4,[5],12:i:-, a monophasic variant of S. Typhimurium(1,4,[5],12:i:1,2) emerged, and is now among the most common serovars isolated from humans in many countries.In Greece, monophasic Typhimurium which was recorded for the first time in human isolates in 2007(0.3% of total isolates), increased sharply thereafter,and since 2009 is the third most frequent serovar. In the present study, 119 S. enterica 1,4,[5],12:i:- strains of human, animal and food origin, isolated during the period between 2006 and 2011, were examined.Strains verified as monophasic Typhimurium variants by polymerase chain reaction (PCR) (97 strains), were further characterised by phenotypic (antibiotic resistance and phage typing) and molecular (pulsed-field gel electrophoresis – PFGE) methods. The results indicate that multiple clones of multiresistant monophasic Typhimurium are circulating in Greece. The most frequently encountered clone in humans and pigs was that of phage type DT120, R-type ASSuTSpTm and PFGEprofile STYMXB.0010, while in poultry other clones were detected. The data indicate that pigs may be a reservoir of this clone in Greece.
Weight loss drugs are compared for effectiveness
Authors: Jacqui Wise
Journal: BMJ (2016)

The obesity drug phentermine-topiramate was associated with the highest odds of achieving weight loss of at least 5% when compared with four other agents, a meta-analysis and systematic review published in JAMA has found.1

The review found that five weight loss drugs, when compared with placebo, were each associated with achieving at least 5% weight loss after a year in overweight or obese adults. The five drugs—orlistat, lorcaserin, naltrexone-bupropion, phentermine-topiramate, and liraglutide—have all been approved by …