tbuckley/cabot-search huggingface dataset:
SAT0023 The Association Between Adipokines Levels, Insulin Resistance and Inflammation in Patients with Early Rheumatoid Arthritis
Authors: L. Kondratyeva, Y. Gorbunova, T. Popkova, A. Avdeeva, E. Aleksandrova, A. Novikov, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Obesity may pose negative impact on the development and progression of rheumatoid arthritis (RA). The adipose tissue is an active endocrine organ that synthesizes adipokines (adiponectin, leptin, etc.). A association between adipokines levels and markers of inflammation are widely discussed. <h3>Objectives</h3> To examine the correlation between adipokins synthesis and levels of inflammatory cytokines in patients with early RA. <h3>Methods</h3> The study included 27 early RA patients (criteria ACR/EULAR, 2010), 56 [46; 64] years old, with median disease duration 8 [6,15] months. The majority of pts were seropositive for IgM RF (89%) and anti-CCP (96%). Medium or high RA activity was documented in all pts (DAS28 5,4 [5,0;6,5]; SDAI 38,9 [24,2;42,9], CDAI 31,6 [20,5; 41,9]). None of RA pts was ever treated with either glucocorticoids (GC) or disease-modifying antirheumatic drugs (DMARD). The control group consisted of 30 healthy subjects without rheumatic diseases, matched by age and sex with RA patients. Serum concentration of adipokines (adiponectin, leptin, and visfatin) was measured with ELISA. A multiplex technology X-MAP was used to measure inflammatory cytokines (interleukins (IL) -1β,2,4,5, 6,7,8,9,10,12,13,15,17). <h3>Results</h3> Adiponectin level was higher in untreated RA patients than in the controls (23,0 [15,8; 67,0] vs 9,2 [5,6; 12,2]ng/ml), while leptin and visfatin concentration were lower than in the control group (25,0 [8,0; 32,0] vs 30,5 [19,0; 46,2]ng/ml, and 434 [336,533] vs 753 [427;1000]ng/ml, respectively, <i>p</i>&lt;0,05 for all). Clear correlation was established between leptin and IL-4 (r=0,39, <i>p</i>=0,04), IL-17 (r=0,4, <i>p</i>=0,03), and ESR (r=0,3, <i>p</i>=0,05) levels. High visfatin concentration was associated with increased IL-5 (r=0,4, <i>p</i>=0,03), and IL-9 (r=0,4, <i>p</i>=0,04) levels. Adiponectin did not show correlation with any of these parameters. The marker of insulin resistance (leptin to adiponectin ratio) correlated with ESR (r=0,38, <i>p</i>=0,05) and CRP (r=0,4, <i>p</i>=0,04). <h3>Conclusions</h3> Statistically significant correlation was established between some adipokines (leptin,visfatin) and Th17, Th2 cytokine levels in DMARD- and GC-naïve early RA patients. <h3>Disclosure of Interest</h3> None declared
OP0170 Treatment of Axial Spondyloarthritis with an Optimal Dosage of Nsaids: A 6-Week Follow Up Study Focusing on Magnetic Resonance Imaging of the Sacroiliac Joints
Authors: G. Varkas, H. Cypers, L. Van Praet, L. Jans, P. Carron, D. Elewaut, F. van den Bosch
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In contrast to the established efficacy of anti- tumor necrosis factor α (TNFα) on BME of the sacroiliac joints (SIJ) (and spine), surprisingly little information exists on the impact of NSAIDs. As NSAID therapy was already the cornerstone of treatment before magnetic resonance imaging of the SIJ was introduced, very limited data on the effect of optimal NSAID therapy on the extent of inflammation, quantified by a validated score such as the Spondyloarthritis Research Consortium of Canada (SPARCC) scoring system, has been published. Our goal was therefore to examine the impact of NSAID use on disease activity and BME in an inception cohort of new onset AxSpA. <h3>Objectives</h3> To evaluate the impact of full dose NSAIDs on the extent and intensity of bone marrow edema of the sacroiliac joints on magnetic resonance imaging in axial spondyloarthritis (AxSpA). <h3>Methods</h3> A single center, 6-week study in a consecutive cohort of patients with clinical suspicion of AxSpA. A total of 102 patients were screened. Thirty- six patients with diagnosis of AxSpA and positive MRI SIJ were included for a follow-up MRI after 6 weeks of optimal dose of NSAIDs. Disease activity was monitored by a BASDAI questionnaire every 2 weeks and BASFI at baseline and week 6. NSAID intake was assessed by the ASAS NSAID- index. Primary endpoints were BASDAI response and improvement of the Spondyloarthritis Research Consortium of Canada (SPARCC) score of MRI SIJ at week 6. <h3>Results</h3> About 38.5% of AxSpA patients was unable to continue the full dose NSAID schedule. Sixteen patients abided completely by the protocol. Median NSAID Index reached 97%. We calculated a mean decrease of 0.4 in BASDAI score per 2 weeks of therapy (P&lt;0.001). Only 18.75% of patients (3/16) reached a BASDAI50 response at week 6. Overall, we found an 8% reduction in mean SPARCC scores at week 6 in comparison to baseline (P=0.046). Fifty percent of patients (8/16) displayed high intensity lesions on STIR at baseline, which decreased significantly at week 6 (P=0.043). <h3>Conclusions</h3> We found a marginal decrease in bone marrow edema of the sacroiliac joints after 6 weeks of optimal NSAID therapy in newly presenting patients with axial spondyloarthritis and a high level of drop out in patients on NSAID therapy in addition to low BASDAI50 response. <h3>Disclosure of Interest</h3> None declared
Surveillance of foodborne botulism in Poland: 1960-1998
Authors: A Galazka, A Przybylska
Journal: Eurosurveillance (1999)

Human foodborne botulism, in contrast to the other two forms of botulism (wound and infant botulism), is an intoxication that results when preformed botulinum toxin is ingested. Sporadic cases and family and general outbreaks occur when food products are
FRI0286 Cardiovascular Risk and Bone Loss in Patients with Erosive and Non-Erosive Hand Osteoarthritis
Authors: O. Ruzickova, O. Sleglova
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hand osteoarthritis (OA) and its more severe subset erosive hand OA are common causes of pain and morbidity. Some metabolic factors were suggested to be implicated in erosive disease. Furthermore, few studies investigated differences in systemic bone loss between erosive and non-erosive hand OA. <h3>Objectives</h3> To compare bone mineral density (BMD) and major cardiovascular risk factors between patients with erosive and non-erosive hand OA in a cross-sectional study. <h3>Methods</h3> Patients with symptomatic disease fulfilling the American College of Rheumatology (ACR) criteria for hand OA were included in this study. Erosive hand OA was defined by at least one erosive interphalangeal joint. All patients underwent clinical assessments of joint swelling and radiographs of both hands. DEXA examination of lumbar spine, total femur and femur neck was performed. Metabolic risk factors (body mass index, hypertension, diabetes, dyslipidaemia) and smoking habits were collected. <h3>Results</h3> Altogether, 134 patients (13 male) with symptomatic nodal hand OA were included in this study between April 2012 and January 2015. Mean (SD) age of all patients was 65.98 (8.16) years and disease duration was 8.54 (7.14) years. Out of these patients, 72 had erosive hand OA. Baseline population characteristics did not differ between both groups. Osteoporosis (T-score &lt;-2.5 SD) was diagnosed in 12.5% (9/72) of patients with erosive hand OA and in 8.06% (5/62) of patients with non-erosive hand OA. Although bone mineral density did not significantly differ between the groups, T-scores of lumbar spine (-0.46 vs. -1.04 SD, p&lt;0.001), total femur (-0.36 vs. -1.20 SD, p&lt;0.001) and femur neck (-0.92 vs. -1.20 SD, p&lt;0.01) were significantly lower in patients with erosive compared with non-erosive disease. Furthermore, there were more patients with dyslipidaemia (p&lt;0.05) and arterial hypertension (p&lt;0.05) among patients with erosive compared with non-erosive hand OA. On the other side, there were less patients with diabetes mellitus (p&lt;0.05) among patients with erosive compared with non-erosive hand OA. <h3>Conclusions</h3> These results suggest that patients with erosive hand OA are at risk for development of general bone loss and cardiovascular diseases. <h3>Acknowledgements</h3> This work was supported by the project MHCR No. 023728. <h3>Disclosure of Interest</h3> None declared
Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus
Authors: Kjeld Schmiegelow, Andishe Attarbaschi, Shlomit Barzilai, Gabriele Escherich, Thomas Leth Frandsen, Christina Halsey, Rachael Hough, Sima Jeha, Motohiro Kato, Der-Cherng Liang, Torben Stamm Mikkelsen, Anja Möricke, Riitta Niinimäki, Caroline Piette, Maria Caterina Putti, Elizabeth Raetz, Lewis B Silverman, Roderick Skinner, Ruta Tuckuviene, Inge van der Sluis, Ester Zapotocka
Journal: The Lancet Oncology (2016)
Soundings: Such gratitude
Authors: Liam Farrell
Journal: BMJ (2001)

Termination of pregnancy remains unavailable in Northern Ireland and it seems to be the only issue on which all political parties agree. This is a commendable moral stance and the fact that 2000 young women travel to Britain every year for a termination is surely an acceptable if unfortunate by-product.

A few years ago I saw a young couple, home on holidays, who were considering a termination. We discussed the pro and cons, and eventually they decided they wanted to proceed with the termination and asked me to make the appointment. But as they were leaving, the girl turned to me and said, “Doctor, what would your advice be?”

Giving advice in an area like this is difficult; every case is so different, every individual so complex. I was inclined at first to be non-directional, to reflect the question back, “What do you think yourself?”

But this time, for some reason, I did give advice, a human, emotional response. They seemed a mature couple, I said, with a good and stable relationship, well fit to give a child a good home. I had seen many similar cases in my time, and I'd never seen a parent regret going ahead with a pregnancy. In nine months, I said, you will look at this little baby and wonder how you ever lived without it.

That's not very scientific, I was thinking even as the words were coming out. What about the real chances of a difficult pregnancy, a horrendous labour, a handicapped baby, postnatal depression, rejection by their families, financial hardship? It won't be my problem, I won't be left holding the baby (so to speak), words are cheap.

I was speaking from the heart, but the heart has made a fool of me many times before.

They left and I heard no more. I didn't know the outcome and had forgotten all about them until, last week, they arrived back at the surgery.

“There is someone we'd like you to meet,” they said, and a little toddler rushed into the room. I lifted him in my arms, and he was bubbling with laughter, the life force dazzling, a golden, shining child, all the freshness of an early world. At least I've done some good in my life, I thought, committing the instantly punishable sin of hubris.

“By the way, he's been a bit sick the last few days,” said the proud mother, as the kid vomited generously over me.
European recommendations on surveillance of antituberculosis drug resistance
Authors: V Schwoebel, C  S B Lambregts, M. L. Moro, F Drobniewski, S. E. Hoffner, M. C. Raviglione, H. L. Rieder
Journal: Eurosurveillance (2000)

Antituberculosis drug resistance, whose extent in Europe is not well documented, is a serious threat to tuberculosis control. The aim of the recent European recommendations on antituberculosis drug resistance surveillance, issued by a working group compos
Adjuvant therapy with fluorouracil and levamisole and liver ultrasound mimicking liver metastases.
Authors: W Kwan, G A Bjarnason, P Hamilton
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.6.1335 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8031402 Adjuvant therapy with fluorouracil and levamisole and liver ultrasound mimicking liver metastases. W KwanxW KwanSearch for articles by this author , G A BjarnasonxG A BjarnasonSearch for articles by this author , P HamiltonxP HamiltonSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.6.1335 PDF "Adjuvant therapy with fluorouracil and levamisole and liver ultrasound mimicking liver metastases.." Journal of Clinical Oncology, 12(6), pp. 1335–1336© 1994 by American Society of Clinical Oncology
How Can We Improve the Implementation of New Endoscopic Techniques? Concerning Colonic Stenting
Authors: S.  Mosca
Journal: Endoscopy (2003)

Endoscopy is a fertile field that frequently offers further new diagnostic and/or therapeutic procedures. Nowadays these procedures are very demanding, and compete with other nonendoscopic techniques; thus, their performance in clinical practice must be optimal, and provide outcomes which compare well with those of nonendoscopic approaches [1] [2]. Furthermore, in the endoscopic community there is great interest in how we can achieve better implementation of any new endoscopic techniques, so that papers such as the ”Expert approach“ series are welcome. In the practice of endoscopy, we need to find technical solutions and strategies from expert experience in order to improve the outcomes of endoscopic practice. I have read with great interest the paper by Baron and co-authors and I wish to make some comments [3]. This paper deals with the expert approach to the placement of expandable metal stents for malignant colorectal obstruction.
Vascular Reactivity in Experimental Diabetes Mellitus
Authors: MICHAEL J. BRODY, ROBERT L. DIXON, Richard A. Shaffer
Journal: Circulation Research (1964)

Vascular reactivity was examined in vessels of the perfused hindquarters of alloxan diabetic and control rats. A significant increase was noted in responsiveness of the diabetic animals to intra-arterial injection of epinephrine, norepinephrine, and synthetic angiotensin. No difference was observed in the vasoconstrictor effects of lumbar sympathetic nerve stimulation or intra-arterial administration of tyramine. Results obtained in diabetic animals were compared with those in animals treated with reserpine. It was found that the reserpinized animals exhibited increased vascular responsiveness only to the catecholamines, and not to angiotensin, vasopressin, tyramine, or barium chloride. Whereas the vascular smooth muscle of diabetic rats was sensitized to epinephrine and norepinephrine, isolated atria from these animals responded normally to the catecholamines. The 24-hour urinary excretion of the catecholamines was significantly elevated in diabetic animals. The data suggest that enhanced vascular reactivity seen in diabetic rats does not result from neuropathy of the sympathetic nervous system. The possible contributions of factors including alloxan per se and body weight to development of increased vascular reactivity in diabetes were considered, but the mechanism for the increase in vascular responsiveness remains unidentified.
Attention in hysteria: a study of Janet's hypothesis by means of habituation and arousal measures
Authors: T Horvath, J Friedman, R Meares
Journal: American Journal of Psychiatry (1980)

Toward the end of the 19th century, Janet suggested that the fundamental disorder in hysteria was one of attention. The authors examined this idea in a study of habituation. Patients with a history of prolonged conversion symptons (N = 11) showed a severe impairment in habituation when compared with patients with anxiety neuroses (N = 10). This finding cannot be explained in terms of arousal and suggests that selective inattention is deficient in hysterical individuals.
Impact of the threatening patient on ward communications
Authors: R B Cornfield, S D Fielding
Journal: American Journal of Psychiatry (1980)

Patients and staff may have difficulty facing the realities of a dangerous situation on an inpatient service. The authors describe how, in response to the presence of a potentially violent patient, distorted patient communications in group settings may be reinforced by staff avoidance patterns. Appropriate therapeutic interventions are often delayed until staff members overcome their resistance to acknowledging the signals that frightened patients send. The authors discuss strategies to circumvent and overcome these problems.
Differing perspectives on mental health evaluation
Authors: G Spivack, C H St Clair, J Siegel, J J Platt
Journal: American Journal of Psychiatry (1975)

Small-group workshops of nonevaluators with differing interests in mental health discussed evaluation priorities for community mental health centers. Participants included center professionals, concerned citizens, and funders. A majority of the participants placed high value on accountability from a consumer standpoint and relatively low value on center management issues and cost or equity of service delivery. Center staff were more interested in efficiency and effectiveness, while outsiders with vested interests were more concerned with community involvement. The authors summarize seven role perspectives and discuss their implications for the establishment of evaluation priorities within a center.
FRI0579 Dynamic Doppler Evaluation of the Hand and Digital Arteries in Patients with Behçet's Disease
Authors: H.N. Özcan, A. Akıncı, M. Kara, T. Tiftik, C. Türkkan, M.A. Öztürk, G. Sungur, L. Özçakar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The pathological process in Behçet9s disease (BD) is autoimmune vasculitis which may involve all types and sizes of vessels. Previous studies evaluated the changes in vascular flow of ocular/carotid arteries, superior/inferior mesenteric artery with Doppler ultrasonography (US) (1,2). On the other hand, although very few, involvement of the distal extremity arteries has been mentioned in BD (3). <h3>Objectives</h3> To evaluate the blood flow parameters of hand arteries in patients with BD by using Doppler US and to determine whether the blood flow parameters correlated with any of the diseases characteristics. <h3>Methods</h3> Twenty-seven (13 F, 14 M) consecutive BD patients and 27 age- and sex-matched healthy controls were included. Demographic and clinical characteristics of the subjects were recorded. Doppler measurements for radial and ulnar arteries (wrist level), and ulnar proper palmar artery (3rd finger distal interphalangeal joint level) were performed bilaterally (Fig. 1). <h3>Results</h3> Mean age of the patients and controls were 35.6±9.2 years (range, 19-59). Patient and control groups were similar as regards body mass index (25.0±3.2 kg/m<sup>2</sup> vs 24.5±2.7 kg/m<sup>2</sup>) and number of smokers (9 vs 11) (both p values &gt;0.05). The diameter and flow volume of radial, ulnar, digital arteries were decreased and pulsatility index were increased in BD group (all p values &lt;0.05). All Doppler values of patients9 radial arteries were significantly different from the control group (all p values &lt;0.05). The diameter, flow volume, peak systolic velocity and end-diastolic velocity were decreased, resistive index and pulsatility index were increased in the radial artery (all p values &lt;0.05). <h3>Conclusions</h3> Our results demonstrated that hand blood flow decreased in BD patients when compared to healthy controls and that the changes were more predominant in the radial artery. Further studies with larger sample sizes with different disease characteristics are warranted to explain the clinical relevance of these findings. <h3>References</h3> Akçar N, Göktekin F, Ozer A, Korkmaz C. Doppler sonography of ocular and carotid arteries in Behçet patients. J Clin Ultrasound 2010;38:486-492. Siğirci A, Senol M, Aydin E, et al. Doppler waveforms and blood flow parameters of the superior and inferior mesenteric arteries in patients having Behçet disease with and without gastrointestinal symptoms: preliminary data. J Ultrasound Med 2003;22:449-457. Onder M, Ozden MG, Aksakal AB, et al. Raynaud phenomenon and behçet disease: diagnosis with technetium Tc 99m methylenediphosphonate bone scan and treatment with continuous sympathetic block. Arch Dermatol 2002;138:698-699. <h3>Disclosure of Interest</h3> None declared
Prerequisites for in vivo cell kinetic studies in patients.
Authors: A Riccardi, M Danova, G Ucci
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.12.1983 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1453213 Prerequisites for in vivo cell kinetic studies in patients. A RiccardixA RiccardiSearch for articles by this author , M DanovaxM DanovaSearch for articles by this author , G UccixG UcciSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.12.1983 PDF "Prerequisites for in vivo cell kinetic studies in patients.." Journal of Clinical Oncology, 10(12), pp. 1983–1984© 1992 by American Society of Clinical Oncology
Rise in the number of notified human hantavirus infections since October 2011 in Baden-Württemberg, Germany
Authors: I Boone, C Wagner-Wiening, D Reil, J Jacob, U M Rosenfeld, R G Ulrich, D Lohr, G Pfaff
Journal: Eurosurveillance (2012)

From October 2011 to April 2012, 852 human hantavirus infections were notified in Germany, of which 580 (68%) were in Baden-Württemberg. Case numbers started to rise earlier than they did before the previous outbreaks in 2007 and 2010, and are the largest ever reported in this state during October to April of any year. The early rise could be due to a beech mast year in 2011, followed by an early and massive reproduction of the reservoir bank vole populations during winter 2011 and spring 2012.