tbuckley/cabot-search huggingface dataset:
PWE-072 Esophageal ESD Procedure Time is Dependent on The Size and Circumferential Extension of The Lesions and &lt;50% of The Time is Actually Spent Performing The Resection: Abstract PWE-072 Table 1
Authors: M Abdulla, A Alkandari, K Kandiah, F Chedgy, G Longcroft-Wheaton, P Bhandari
Journal: Gut (2016)

<h3>Introduction</h3> Endoscopic submucosal dissection (ESD) is superior to endoscopic mucosal resection(EMR) as it leads to en-bloc resection &amp; reduces risk of recurrence. However, western uptake has been limited due to long learning curve and procedure time.We aim to establish the time required for each component of ESD and identify factors predicting it. <h3>Methods</h3> A single, experienced, western Endoscopist performed all procedures for suspected Barrett’s cancers &gt;2 cm. Procedures were recorded in full on a digital recorder. First 30 procedures were considered as a part of learning curve and not analysed. All subsequent consecutive procedures were analysed by an independent researcher with knowledge of ESD.Lesion area was calculated based on length of the lesion and the percentage of the oesophageal circumference involved. Using the equation area = 2*π* r * l *% circumferential involvement / 100. Here r = radius and l = length of lesion. The time for every component of the procedure was recorded: lesion evaluation &amp; marking, submucosal (SM) injection, mucosal incison, SM dissection, haemostasis &amp; post-ESD site evaluation. <h3>Results</h3> 29 consecutive videos were examined. All lesions were Barrett’s cancers (25% T-1b, 75% T-1a). The mean length was 30 mm (range:20-70mm), with mean area of 8.2cm<sup>2 </sup>(range:1.6-23cm<sup>2</sup>). The mean procedure time was 81 mins (range:45-142min), equating to 9.9 min/ cm<sup>2 </sup>.The time taken for each component of the procedure is shown in fig. 1. Only 42% of the time was spent in cutting (Mucosal incision and SM dissection). 24% of time was spent in evaluation and marking the margins. 24% of the time spent in changing accessories &amp; injection. Procedure time was related to lesion area: 100 min for lesions &gt;10cm<sup>2</sup> vs 72 mins for lesions &lt;5 cm<sup>2</sup>(p = 0.0056).Circumferential extension had an effect, with &lt;25% circumference taking 66 min vs 92 mins for lesions with &gt;25% circumferential extension (p = 0.0025) <h3>Conclusion</h3> Our data shows that it takes 9.9 min/ cm<sup>2 </sup>to perform ESD for Barrett’s cancers. Time taken is directly related to the size and circumferential extent of the lesion. We found that only 42% of the time is spent performing the actual resection and rest of the time is spent in supporting acts. This information can help focus the future research in reducing the ESD procedure time and also help plan appropriate time and remuneration for current ESD procedures. <h3>Disclosure of Interest</h3> None Declared
Single Donor 4/6 Matched Banked Unrelated Cord Blood Is An Effective Graft Source for Children Undergoing Myeloablative Transplantation for Malignant and Nonmalignant Disorders: Single Center Analysis of 318 Patients.
Authors: Vinod K. Prasad, Premjit Gill, Richard Vinesett, Suhag H Parikh, Paul Szabolcs, Timothy A Driscoll, Kristin M Page, Susan Wood, Deborah Semmel, Paul L Martin, Joanne Kurtzberg
Journal: Blood (2008)
Abstract LB-064: Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma
Authors: Ana Ortega-Molina, Isaac Boss, Heng Pan, Yanwen Jiang, Deqing Hu, Xin Gao, Rita Shaknovich, Ali Shilatifard, Ari M. Melnick, Hans-Guido Wendel
Journal: Cancer Research (2015)

Abstract Follicular lymphoma (FL) is a common and incurable form indolent B-cell lymphoma. Genomic studies have now catalogued many recurrent mutations in FL. Epigenetic regulators have emerged as the most common targets of somatic point mutations. For example, the histone methyltransferase KMT2D (MLL4/MLL2) is the most frequently mutated gene in FL with reported mutational frequencies of up to 84%. However, the transcriptional and biological consequences of KMT2D loss of function are currently unknown. Using a well-described murine model of FL, we showed that deficiency of KMT2D promotes the initiation of indolent FL in vivo. To explore the mechanism of KMT2D-mediated tumor suppression we used cross species comparisons of gene expression, histone H3K4 methylation marks and KMT2D genomic occupancy. These analyses converge on a relatively small group of conserved target genes. Strikingly, they include bona fide tumor suppressors and regulators of B-cell proliferation (e.g. TNFAIP3/A20, SOCS3, ARID1A, and TNFRSF14). Our results indicate that KMT2D restrains FL development through simultaneous effects on multiple key regulators of B-cell behavior. Note: This abstract was not presented at the meeting. Citation Format: Ana Ortega-Molina, Isaac Boss, Heng Pan, Yanwen Jiang, Deqing Hu, Xin Gao, Rita Shaknovich, Ali Shilatifard, Ari M. Melnick, Hans-Guido Wendel. Characterization of the tumor suppressor function of the lysine-specific methyltransferase KMT2D in follicular lymphoma. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr LB-064. doi:10.1158/1538-7445.AM2015-LB-064
SP0030 Capillaroscopic versus Laser Doppler Analysis of The Microcirculation
Authors: A.L. Herrick
Journal: Annals of the Rheumatic Diseases (2016)

Nailfold capillaroscopy is used primarily to study microvascular <i>structure,</i> and in patients with Raynaud9s phenomenon (RP) helps to differentiate between primary (idiopathic) RP and RP secondary to an underlying systemic sclerosis-spectrum disorder. In contrast, laser Doppler techniques measure microcirculatory blood flow, and therefore assess microvascular <i>function</i>. Capillaroscopy and laser Doppler are therefore complementary. There are different laser Doppler techniques: flowmetry (using a single probe), laser Doppler imaging (LDI), and laser speckle contrast imaging (LSCI). LDI and LCSI both measure blood flow over an area rather than at a single site. Laser Doppler techniques have been applied in research studies in patients with RP and systemic sclerosis, including as outcome measures in clinical trials: protocols often involve dynamic imaging, measuring blood flow response to (for example) a standard temperature stimulus. This lecture will describe the main applications of capillaroscopy and laser Doppler techniques in clinical practice and research, relevant to the rheumatologist, and the rationale underpinning these. Upon completion of the session, participants should be able to: 1. Discuss applications of capillaroscopy and different laser Doppler methods in patients with RP and systemic sclerosis 2. Discuss similarities and differences between the techniques. <h3>Disclosure of Interest</h3> None declared
Four Drugs Combination (Fludarabine, Cytarabine, Idarubicin, Etoposide) as Induction Therapy for Newly Diagnosed Acute Myeloid Leukemia Patients Younger Than 65 Ys: Response and Follow-up of 84 Patients.
Authors: Michela Rondoni, Michele Malagola, Stefania Paolini, Marzia Defina, Pier Paolo Piccaluga, Lara Aprile, Cristina Papayannidis, Nicoletta Testoni, Rosaria Crupi, Alessandro Gozzetti, Monica Tozzi, Giuseppe Marotta, Francesca Toraldo, Domenico Russo, Monica Bocchia, Michele Baccarani, Giovanni Martinelli, Francesco Lauria
Journal: Blood (2009)
Trends in Injury Outcomes Across Canadian Trauma Systems
Authors: Lynne Moore, Henry Thomas Stelfox, David Evans, Sayed Morad Hameed, Natalie L. Yanchar, Richard Simons, John Kortbeek, Gilles Bourgeois, Julien Clément, Alexis F. Turgeon, François Lauzier
Journal: JAMA Surgery (2016)

<h3>Importance</h3> In response to the burden of injury, the structure of injury care has changed considerably across Canada in the past decade. However, little is known about how patient outcomes have evolved. <h3>Objective</h3> To evaluate trends in mortality, hospital length of stay, and unplanned readmission in Canadian trauma systems between 2006 and 2012. <h3>Design, Setting, and Participants</h3> A pan-Canadian retrospective cohort study was conducted among adults admitted for major injury to a Canadian level I or II trauma center between April 1, 2006, and March 31, 2012. Data analysis was conducted from April 15 to December 3, 2015. <h3>Exposures</h3> Trauma centers and systems. <h3>Main Outcomes and Measures</h3> Multilevel generalized linear models were used to evaluate trends in the risk-adjusted incidence of mortality and readmission and risk-adjusted mean length of stay. Trend analyses were conducted globally and by province. <h3>Results</h3> Among 78 807 patients (mean [SD] age, 50.7 [22.0] years; 22 540 women and 56 267 men) admitted for major injury during the study period, risk-adjusted mortality decreased from 12.1% (95% CI, 9%-16.1%) to 9.9% (95% CI, 7.4%-13.3%;<i>P</i> &lt; .001) and mean length of hospital stay decreased from 11.6 (95% CI, 9.9-13.6) to 10.6 (95% CI, 9.1-12.5) days (<i>P</i> &lt; .001). Statistically significant reductions in mortality were observed for Ontario (12% [95% CI, 10.7%-13.6%] to 8% [95% CI, 6.9%-9.2%];<i>P</i> &lt; .001), Alberta (12% [95% CI, 10%-14.3%] to 9.1% [95% CI, 7.7%-10.8%];<i>P</i> = .02), and Manitoba (13% [95% CI, 9.1%-18.4%] to 11.1% [95% CI, 8.3%-14.7%];<i>P</i> = .04). Risk-adjusted hospital stay decreased significantly in Québec (11.6 [95% CI, 11.1-12] to 9.1 [95% CI, 8.9-9.5] days;<i>P</i> &lt; .001), British Columbia (12.5 [95% CI, 12-13.1] to 11.4 [10.9-11.9] days;<i>P</i> &lt; .001), and Ontario (10.1 [95% CI, 9.8-10.4] to 9.8 [95% CI, 9.5-10.1] days;<i>P</i> &lt; .001). No change in the incidence of readmission was observed. <h3>Conclusions and Relevance</h3> We observed an 18.2% relative decrease in risk-adjusted mortality in Canadian trauma centers during the study period, representing 248 additional lives saved in 2012 vs 2006. Risk-adjusted mean hospital stay decreased by 8.6%, representing nearly 10 000 hospital days saved. A better understanding of the structures and processes behind observed improvements is needed to further reduce the burden of injury in Canada.
Researcher suing PubPeer was found culpable of misconduct, court documents show
Authors: Owen Dyer
Journal: BMJ (2016)

A researcher who is suing the website PubPeer in order to unmask anonymous commentators who questioned his research integrity had previously been found to have engaged in “widespread research misconduct” by investigators from Wayne State University, his former employer.

The report into the conduct of Fazlul Sarkar was obtained under a freedom of information request from the university by lawyers for the American Civil Liberties Union, who are representing PubPeer in the case. They are seeking to introduce it as evidence and have published it online.1

Sarkar “engaged in and permitted (and tacitly encouraged) intentional and knowing fabrication, falsification, or plagiarism …
Metformin Is Associated With Higher Relative Abundance of Mucin-Degrading <i>Akkermansia muciniphila</i> and Several Short-Chain Fatty Acid–Producing Microbiota in the Gut
Authors: Jacobo de la Cuesta-Zuluaga, Noel T. Mueller, Vanessa Corrales-Agudelo, Eliana P. Velásquez-Mejía, Jenny A. Carmona, José M. Abad, Juan S. Escobar
Journal: Diabetes Care (2016)

OBJECTIVE Recent studies suggest the beneficial effects of metformin on glucose metabolism may be microbially mediated. We examined the association of type 2 diabetes, metformin, and gut microbiota in community-dwelling Colombian adults. On the basis of previous research, we hypothesized that metformin is associated with higher levels of short-chain fatty acid (SCFA)–producing and mucin-degrading microbiota. RESEARCH DESIGN AND METHODS Participants were selected from a larger cohort of 459 participants. The present analyses focus on the 28 participants diagnosed with diabetes—14 taking metformin— and the 84 participants without diabetes who were matched (3-to-1) to participants with diabetes by sex, age, and BMI. We measured demographic information, anthropometry, and blood biochemical parameters and collected fecal samples from which we performed 16S rRNA gene sequencing to analyze the composition and structure of the gut microbiota. RESULTS We found an association between diabetes and gut microbiota that was modified by metformin use. Compared with participants without diabetes, participants with diabetes taking metformin had higher relative abundance of Akkermansia muciniphila, a microbiota known for mucin degradation, and several gut microbiota known for production of SCFAs, including Butyrivibrio, Bifidobacterium bifidum, Megasphaera, and an operational taxonomic unit of Prevotella. In contrast, compared with participants without diabetes, participants with diabetes not taking metformin had higher relative abundance of Clostridiaceae 02d06 and a distinct operational taxonomic unit of Prevotella and a lower abundance of Enterococcus casseliflavus. CONCLUSIONS Our results support the hypothesis that metformin shifts gut microbiota composition through the enrichment of mucin-degrading A. muciniphila as well as several SCFA-producing microbiota. Future studies are needed to determine if these shifts mediate metformin’s glycemic and anti-inflammatory properties.
From Renal Siderosis Due to Perpetual Hemosiderinuria to Possible Liver Overload Due to Extravascular Hemolysis: Changes in Iron Metabolism in Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients On Eculizumab.
Authors: Antonio M. Risitano, Elisa Seneca, Ludovica Marando, Massimo Imbriaco, Ernesto Soscia, Francesca Soscia, Laura Micol Pizzuti, Luca Malcovati, Susanna Fenu, Anna Paola Iori, Rosario Notaro, Margherita Matarazzo, Bruno Rotoli
Journal: Blood (2009)
Low-Dose 28-Day Metronomically Scheduled Therapy (METRO) for Newly Diagnosed High-Risk Multiple Myeloma: A Pilot Study
Authors: Rashid Z Khan, Yogesh Jethava, Xenofon Papanikolaou, Caleb K Stein, Adam Rosenthal, Christoph Heuck, Frits van Rhee, Jameel Muzaffar, Maurizio Zangari, Clyde Bailey, Phillip Farmer, Bart Barlogie
Journal: Blood (2014)
Constitutive Expression of the ABCG2 (BCRP), the Molecular Determinant of the Side Population, Increases the Proliferative Potential of Human Clonogenic Progenitors and Supports Human Myeloid Engraftment in the NOD/SCID Mouse Model.
Authors: Farid Ahmed, Natalia Arseni, Wolfgang Hiddemann, Christian Buske, Michaela Feuring-Buske
Journal: Blood (2005)
Microarray Classification of Myelodysplastic Syndrome (MDS) Identifies Subgroups with Distinct Clinical Outcomes.
Authors: Ken I. Mills, Alex Kohlmann, Mickey Williams, Wei-Min Liu, Rachel Li, David T. Bowen, Helmut Loeffler, Jesus M. Hernandez, Wolf-Karsten Hofmann, Torsten Haferlach, Lothar Wieczirek
Journal: Blood (2007)
Combination of Oxaliplatin, Fludarabine, Cytarabine, and Rituximab in Richter’s Syndrome and Fludarabine-Refractory Chronic Lymphocytic Leukemia.
Authors: Apostolia-Maria Tsimberidou, William G. Wierda, Susan O’Brien, William W. Plunkett, Thomas J. Kipps, Jennifer R. Brown, Susan Lerner, Hagop Kantarjian, Michael J. Keating
Journal: Blood (2006)
Cancer Patients Requiring Interruption of Long-Term Anticoagulant Therapy: The Use of Fixed Sub-Therapeutic Doses of Low-Molecular Weight Heparin
Authors: Giorgia Saccullo, Alessandra Malato, Lucio Lo Coco, Ilenia Barbello, Clementina Caracciolo, Simona Raso, Marco Santoro, Orazio Graziano Di Bartolo, Ambra Di Piazza, Vincenzo Abbadessa, Sergio Siragusa
Journal: Blood (2011)
Interim Analysis of the IELSG-19 Randomised Study of Chlorambucil Alone Versus Chlorambucil Plus Rituximab Versus Rituximab Alone in Extranodal Marginal Zone Lymphomas of Mucosa-Associated Lymphoid Tissue (MALT lymphoma).
Authors: Emanuele Zucca, Annarita Conconi, Maurizio Martelli, Catherine Thieblemont, Peter Johnson, Armando Lopez Guillermo, Reda Bouabdallah, Alessandra Tucci, Umberto Vitolo, Bertrand Coiffier, Liliana Devizzi, Fabrice Jardin, Catherine Sebban, Graziella Pinotti, Franck Morschhauser, Ruth Pettengell, André Bosly, Emilio Montserrat, Monica Bellei, Stefano A. Pileri, Christiane Copie-Bergman, Elias Campo, Andrew Jack, Luca Mazzucchelli, Irene Floriani, Daniela Garavaglia, Valter Torri, Franco Cavalli, Giovanni Martinelli
Journal: Blood (2009)
Donor Chimerism Is a Key Predictor of Graft Failure and the Response of Adoptive Immunotherapy Following Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Xiaowen Tang, Qiurong Zhang, Yufeng Feng, Ziling Zhu, Yaojun Liu, Shengli Xue, Aining Sun, De Pei Wu
Journal: Blood (2007)
The Hypomethylating Agent Decitabine Prior to Chemotherapy Improves the Therapy Efficacy in Refractory/Relapsed Acute Myeloid Leukemia Patients
Authors: Xuejie Jiang, Zhixiang Wang, Changxin Yin, Guopan Yu, Jieyu Ye, Yu Zhang, Zhiping Fan, Dan Xu, Xiaoli Liu, Ru Feng, Bing Xu, Jing Sun, Qifa Liu, Bing Z Carter, Fanyi Meng
Journal: Blood (2015)
Growing Numbers of Refugees Worldwide Are Children
Authors: M. J. Friedrich
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Results of a Phase I-II Study of Fenretinide and Rituximab for Patients with B-Cell Lymphomas
Authors: Andrew J. Cowan, Philip Stevenson, Ted A. Gooley, Shani L. Frayo, George R. Oliveira, Stephen D. Smith, Damian J. Green, Jennifer E. Roden, John M. Pagel, Brent L Wood, Oliver W Press, Ajay K. Gopal
Journal: Blood (2015)
Efficacy of Rituximab Combined in Salvage- and High Dose-Therapy (HDT) for Patients with Relapsed NHL; Interim Analysis of a Multicenter Phase II Study.
Authors: G. Hess, T. Flohr, N. Frickhofen, H. Wolf, M. Gramatzki, H. Link, N. Peter, N. Basara, N. Schmitz, A. Banat, M. Kneba, C. Huber, G. Derigs
Journal: Blood (2004)
PTH-156 Impact of BSG and BASL Liver Care Bundle Introduction on Clinical Practice: A University Hospital Experience: Abstract PTH-156 Table 1
Authors: S Shahid, V Cheung, H Meghji, N Rajoriya, G MacFaul
Journal: Gut (2016)

<h3>Introduction</h3> The National Confidential Enquiry into Patient Outcome and Death for alcohol related liver disease highlighted the need to improve care of patients with decompensated liver disease. BSG and BASL thereafter developed the Liver Care Bundle toolkit to aid provision of evidence-based care within 24 hours of admission. We performed an audit of care delivered to such patients before and after introduction of the Bundle into clinical practice in our hospital. <h3>Methods</h3> For the initial audit (August 2014-March 2015), patients presenting with decompensated liver disease were retrospectively identified from ward lists, blood bank data for Human Albumin Solution (HAS), and the endoscopy database. Electronic patient records were reviewed against the toolkit. The results were presented at hospital Grand round alongside presentation of the Liver Care Bundle which was, thereafter, implemented throughout the Trust from July 2015. Re-audit using the same methodology was performed September to December 2015. The significance of impact of the Bundle on clinical practice was evaluated using Fisher’s exact test. <h3>Results</h3> 45 patients were identified for the first part of the audit. The average length of stay was 11 days. Notes for 20 patients with 25 in-patient episodes were reviewed for the re-audit. Average length of stay was 18 days. <h3>Conclusion</h3> The introduction of the Liver Care Bundle at our institution led to improvement in several aspects of care- especially in the management of variceal haemorrhage. Recognition of patients with excess alcohol consumption and use of Pabrinex was improved upon too. There, however, remain clear areas for improvement. Experiences with the Liver Care Bundle should continue to be widely reported in an attempt to standardise and improve in-patient morbidity and mortality in liver disease. <h3>Reference</h3> 1 McPherson S, <i>et al.</i> Response to the NCEPOD report: development of a care bundle for patients admitted with decompensated cirrhosis—the first 24 h. <i> Frontline Gastroenterol.</i> 2016 Jan;<b>7</b>(1):16–23. Epub 2014 Dec 2. <h3>Disclosure of Interest</h3> None Declared
Biodegradable Nitrogen-Doped Carbon Nanodots for Non-Invasive Photoacoustic Imaging and Photothermal Therapy
Authors: Changho Lee, Woosung Kwon, Songeun Beack, Donghyun Lee, Yoonsang Park, Hyemin Kim, Sei Kwang Hahn, Shi-Woo Rhee, Chulhong Kim
Journal: Theranostics (2016)

Multifunctional nanoparticles have been widely investigated for biomedical applications, such as imaging, therapy, and drug delivery.Especially, photoactive nanoparticles have received great attention as theranostic agents because of their heat-generating abilities after exposure to laser irradiation.However, photostability and safety issues have been the technical hurdles for further clinical applications.Here, we designed nitrogen (N)-doped carbon nanodots (N-CNDs) that have strong absorption in the near-infrared region, high photostability, and excellent biodegradability.Optimized N-CNDs can be utilized not only as a new photoacoustic (PA) imaging agent but also as a superior photothermal therapy (PTT) agent in vivo because of their strong optical absorption at a specific wavelength.We used N-CNDs to perform in vivo/ex vivo noninvasive PA imaging of sentinel lymph nodes via local delivery and performed PTT for cancer ablation therapy.Finally, biodegradation and renal clearance were confirmed by performing whole-body PA monitoring and a degradation test.
Ofatumumab-Bendamustine As First Line Treatment for Elderly Patients with Mantle Cell Lymphoma: A Phase II Risk Adapted Design with Comprehensive Geriatric Assessment
Authors: Carla Casulo, Augustine Iannotta, Jannelle Walkley, Craig H. Moskowitz, Alison J Moskowitz, Pamela Drullinsky, Andrew D. Zelenetz, Paul Hamlin
Journal: Blood (2014)