tbuckley/cabot-search huggingface dataset:
Breast cancer mortality trends in the WEST compared to the EAST: lives gained, lives lost.
Authors: J Ragaz, P Bao, P Pisani, Y Zheng
Journal: Cancer Research (2009)

Abstract Abstract #6082 INTRODUCTION: Breast Cancer (BrCa) Mortality trends between 1950 – 2005 were reviewed between the Western (WEST) and Eastern Asian (EAST) countries, with the objective to gain understanding between therapeutic and diagnostic interventions and underlying epidemiology factors determining BrCa outcomes.&amp;#x2028; METHODOLOGY: We compared BrCa mortality trends in the WEST (Canada, UK, USA) and in the EAST (Japan and China-Shanghai). Data were obtained from WHO - IARC, Lyon (Canada, USA, UK, Japan); and from the Shanghai Cancer Registry (China-Shanghai). We analyzed age-standardized annual mortality rates per 100,000 / population (as per 1960 world standard population). Mortality trends were expressed relative to the baseline (year 1950 for all, year 1973 for China-Sha).&amp;#x2028; RESULTS: The baseline mortality rates were: 22.5 for Canada; 23.5 for UK; 21.6 for USA, 4.1 for Japan; and 7.3 for China-Shanghai.&amp;#x2028; &amp;#x2028; CONCLUSION. These data confirm a substantial mortality reduction in the WEST evident after the 1980's - 1990's, likely reflecting the interaction of diagnostic and therapeutic interventions (mammography, education, systemic / locoregional therapies, etc). The different timing and extent of mortality reduction in the WEST probably reflect different degree of implementation of the interactive factors.&amp;#x2028; On the other hand, mortality is increasing in the EAST, in parallel with the “westernization” of those regions (industrialization, diet, etc, Ref. [NEJM; 2008:358;3)]. For the EAST, our data also support a correlation between the timing / extent of the “westernization” and mortality trend dynamics (i.e. mortality increase in Japan 20 years earlier than China). Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6082.
P856 NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) AND THE RISK OF COLORECTAL ADENOMAS AND ADVANCED NEOPLASM. A PROSPECTIVE STUDY
Authors: A. Tantau, M. Tantau, P. Szanto, D. Crisan, I. Visovan, V. Negrean, D. Sampelean
Journal: Journal of Hepatology (2014)
Abstract 4946: Control of cellular proliferation by ERK: A quantitative analysis in single cells
Authors: John G. Albeck, Gordon B. Mills, Joan S. Brugge
Journal: Cancer Research (2012)

Abstract The EGF-stimulated ERK/MAPK system is a key conduit for physiological growth signals. We have used a combination of live and fixed single-cell measurements to determine the quantitative operating principles of this pathway under long-term stimulation by physiological levels of EGF, revealing three essential properties of the network. First, the extracellular concentration of EGF is encoded, at different points in the network, by distinct frequency- and amplitude-modulated responses. Second, control of cellular proliferation is controlled predominantly by the lower end of the pathway's dynamic range, necessitating nearly complete inhibition of the pathway to elicit growth arrest. Third, the diverse phenotypic outputs of the pathway are controlled by different segments of the overall dynamic range, with distinct molecular targets engaged at different thresholds. These properties have direct relevance to strategies for therapeutic inhibition of the ERK/MAPK network. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4946. doi:1538-7445.AM2012-4946
Abstract 4716: Chronic alcohol consumption activates the LiTAF pathway in melanoma-bearing mice.
Authors: Andrew Marron, Hui Zhang, Zhaohui Zhu, Gary G. Meadows
Journal: Cancer Research (2013)

Abstract We previously reported that chronic alcohol consumption increases myeloid-derived suppressor cells (MDSC) and compromises melanoma-specific CD8+ T cells in B16BL6 melanoma-bearing mice; however, the underlying mechanism has not been elucidated. Activation of LPS-induced TNF-α factor (LiTAF) gene leads to up-regulation in the expression of various cytokines, chemokines and growth factors such as TNF-α, IL-1β, and VEGF, which are inducers of MDSC. Alcohol consumption is associated with the leakage of LPS into the blood. However, it is not known whether alcohol consumption modulates the expression of LiTAF. Herein, we examined the effects of alcohol and subcutaneous inoculation of melanoma in mice on the expression of LiTAF and its downstream cytokines, chemokines and growth factors. Female C57BL/6 mice were given 20% (w/v) alcohol for three to six months followed by subcutaneous inoculation of 2x105 B16BL6 melanoma cells. Two weeks after tumor inoculation, the expression of LiTAF and related cytokine genes in the spleen were examined by RT-PCR. Chronic alcohol consumption dramatically up regulated the expression of LiTAF in the spleen of melanoma-bearing mice; however, expression was almost undetectable in the spleen of corresponding water-drinking mice. The expression of IL-1β, IL-10, TNF-α, CCL5, and VEGF-β was also significantly up regulated by alcohol. These results indicate that chronic alcohol consumption activates the LiTAF pathway and up regulates the expression of the downstream cytokines, chemokines and growth factors. The up regulation of these cytokines could contribute to the induction of MDSC and inhibition on CD8+ T cells. (Supported by funds received from the Summer Undergraduate Research Fellowship (SURF) Program, from NIH grants R01 AA07193 and K05AA017149, and from funds provided for medical and biological research by the State of Washington Initiative Measure No. 171). Citation Format: Andrew Marron, Hui Zhang, Zhaohui Zhu, Gary G. Meadows. Chronic alcohol consumption activates the LiTAF pathway in melanoma-bearing mice. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4716. doi:10.1158/1538-7445.AM2013-4716
TCT- 472 Impact of Excess Dosing of Eptifibatide During PCI for ACS: A Pooled Analysis from the HORIZONS-AMI and ACUITY Trials
Authors: Mahesh V. Madhavan, Philippe Genereux, Ke Xu, Ovidiu Dressler, Roxana Mehran, Gregg W. Stone
Journal: Journal of the American College of Cardiology (2014)
Abstract 726: Fluorophore-conjugated antibodies improve surgical resection of pancreatic cancer leading to prolonged disease-free survival and overall survival in orthotopic mouse models.
Authors: Cristina A. Metildi, Sharmeela Kaushal, Mark A. Talamini, George A. Luiken, Robert M. Hoffman, Michael Bouvet
Journal: Cancer Research (2013)

Abstract We established orthotopic mouse models of human pancreatic cancer with fragments of BxPC-3-RFP tumor. Two weeks after implantation, mice were randomized to FGS or bright-field surgery (BS). FGS was performed 24 hrs after tail vein injection of anti-CEA-Alexa 488. Completeness of resection was assessed from pre- and postoperative images obtained with the OV-100 Small Animal Imaging System. Whole body images of mice were obtained postoperatively to assess for recurrence and mice were followed until premorbid to measure survival. We achieved a complete resection of pancreatic cancers in 92% of mice in the FGS group as compared to 58% in the BS group (p=0.002). Preoperative tumor burden was not significantly different between groups (p=0.424). However, FGS afforded a significantly smaller mean postoperative tumor burden compared to BS: 0.0004 ± SE 0.0003 mm2 vs. 0.0841 ± SE 0.027 mm2, p=0.004. On average, mice in the FGS experienced a greater reduction in tumor burden: 99.99% vs 97.72%, p=0.01. FGS reduced recurrence rates from 95% to 50% (p=0.002) and lengthened mean disease-free survival from 7 weeks to 30.5 weeks (p&amp;lt;0.001). The FGS group experienced longer overall survival compared to the BS group: 16.5 weeks vs. 37 weeks (p=0.001). Cure rate was improved with FGS from 5% to 50% (p=0.003). Furthermore, FGS more than doubled the one-year postoperative survival rate from 3 mice in the BLS group to 8 mice in the FGS group (p=0.005). This novel approach has potential to improve outcomes in the surgical treatment of pancreatic cancer. Survival and recurrence according to surgical mode. Surgical Mode Disease-Free Survival Overall Survival Recurrence Rate Bright-Field Surgery 7 weeks 16.5 weeks 95% Fluorescence-Guided Surgery 30.5 weeks 37 weeks 50% Citation Format: Cristina A. Metildi, Sharmeela Kaushal, Mark A. Talamini, George A. Luiken, Robert M. Hoffman, Michael Bouvet. Fluorophore-conjugated antibodies improve surgical resection of pancreatic cancer leading to prolonged disease-free survival and overall survival in orthotopic mouse models. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 726. doi:10.1158/1538-7445.AM2013-726
FDG PET Evaluation of Residual Masses and Regrowth of Abdominal Lymph Node Metastases From Colon Cancer Compared With CT During Chemotherapy
Authors: TAKASHI YOSHIOKA, HIROSHI FUKUDA, TAKEHIKO FUJIWARA, REN IWATA, TATUO IDO, YASUKO MURAKAWA, MAKIO GAMO, CHIKASHI ISHIOKA, RYUNOSUKE KANAMARU
Journal: Clinical Nuclear Medicine (1999)

Fluorine-18-2-deoxy-2-fluoro-D-glucose (F-18 FDG) PET may be more suitable for follow-up after cancer treatment than other morphologic approaches, because it reflects tumor viability. A patient with abdominal lymph node metastases from colon cancer was followed by CT and F-18 FDG PET during chemotherapy. F-18 FDG PET tumor images changed in accordance with the clinical progress, whereas CT findings were relatively unchanged. This case clearly shows the utility of F-18 FDG PET for follow-up during cancer chemotherapy.
PREPARATION AND CHARACTERIZATION OF Re-186 LABELED NR-Co-02 F(abʼ)2: A NOVEL ANTI-CEA ANTIBODY FRAGMENT FOR RADIOIMMUNO THERAPY.
Authors: J-L Vanderheyden, S. Gofinch, A. Srinivasan, Fu Min Su, P. Venkatesan, C. Woodhouse, P. Lu, R. Berninger, K. Marchitto, J. Reno, P. Beaumier, A. Fritzberg
Journal: Clinical Nuclear Medicine (1988)

Vanderheyden, J-L; Gofinch, S.; Srinivasan, A.; Su, Fu Min; Venkatesan, P.; Woodhouse, C.; Lu, P.; Berninger, R.; Marchitto, K.; Reno, J.; Beaumier, P.; Fritzberg, A. Author Information
Summary and Perspectives
Authors: J. Heslop-Harrison
Journal: Environmental Health Perspectives (1978)

The job of attempting any sort of summary of so much material of such diversity is a formidable one, certainly when the task allocated includes sketching some perspectives. I shall attempt to tackle it in three stages, first mentioning some of the highlights from the various contributions, then offering a few general comments on characteristics of higher plants as test subjects for mutagen monitoring, and concluding with a brief-indeed very briefconsideration of perspectives. My comments are from one whose interests lie in plant physiology and cytogenetics; I am not myself active in the field of mutagenesis, so I hope you will bear with my deficiencies should anything I say sound erroneous or tendentious. The workshop opened with the paper from Dr. de Serres, who offered us some targets for the meeting. He reminded us of the range of purposes for which we may wish to monitor the environment for mutagenic agents, noting that we are not only concerned with the well-being of man, but with his plants and animals-and one might hope also the biome at large, not only those elements of it of direct human concern. He mentioned the impressive figure of 63,000 man-made chemicals now littered about the earth, with a growth rate of some 3000 new ones per year: indeed an intimidating screening task. As for the screening systems, he stressed the need for specificity; the requirement that the data gathered should be relevant to the problem, a consideration of great importance when it is proposed to extrapolate from results obtained with one class of organism to another, different, class. Dr. Heath followed with a sobering talk in which he gave us a glimpse of cancer epidemiology in the U. S. Among the many significant points he made I recall especially his comment on the long latent period between first exposure to a causal agent and the ultimate effect. He referred to the case histories of
18F-FDG PET/CT Demonstrated the Multiple Myeloma From Prostate
Authors: Aiping Cheng, Fu Liping, Xiaogang Wang, Lijun Zhao, Jigang Yang
Journal: Clinical Nuclear Medicine (2015)

Prostatic plasmacytoma is an exceptionally rare type of multiple myeloma. The present study reports a patient with multiple myeloma arising from the prostate, with normal serum and urine monoclonal protein. The final diagnosis of multiple myeloma from prostate was based on pathologic and immunohistochemical findings.
A1.2 Prominent role of pathogenic memory CCR6+ TH17 cell populations in the pathogenesis of ACPA+ patients with rheumatoid arthritis
Authors: SMJ Paulissen, JP van Hamburg, N Davelaar, H Vroman, W Dankers, JMW Hazes, PHP de Jong, E Lubberts
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Patients with rheumatoid arthritis (RA) positive for serum anti-citrullinated protein antibodies (ACPAs) have a worse disease course than ACPA- patients. Association of ACPA and HLA-DRB1 suggests the involvement of T cells in ACPA+ RA. Therefore we examined possible differences in memory CD4<sup>+</sup> T (Th) cell distribution between ACPA+ and ACPA- patients and their functional relevance. <h3>Materials and methods</h3> Th cell distribution profiles from ACPA+ and ACPA- patients with early RA were generated based on chemokine receptor, cytokine and transcription factor expression. On the basis of CXCR3 and CCR4 expression, four CCR6+ subpopulations were distinguished: Th17, Th17.1, CCR4/CXCR3 double positive (DP) and double negative (DN) cells. These Th cell populations were analysed for their pathological potential. <h3>Results</h3> ACPA+ patients had higher proportions of peripheral CCR6+ Th cells, notably Th22, Th17.1 and DP cells. All CCR6+ subpopulations were also present in RA synovial fluid. These subpopulations shared Th17 characteristics including RORC and CD161 expression. However, expression of IL-17A, IL-17F, IFNg and the Th1-associated transcription factor TBX21 differed markedly between CCR6+ subpopulations. Nevertheless, all CCR6+ Th cell subpopulations showed higher pathological activity than naive and Th1 cells, as they were more effective in stimulating IL-1β, IL-6, IL-8, COX-2 and MMP-3 expression by synovial fibroblasts. Interestingly, CCR6+ Th populations are inverse correlated with disease duration in ACPA- patients but not in ACPA+ patients. <h3>Conclusions</h3> ACPA+ and ACPA- patients can be distinguished by differences in pathogenic memory CCR6+ Th cell proportions, suggesting that these cells are involved in the worse disease course observed in ACPA+ RA.
Chloramphenicol-Resistant<i>Salmonella newport</i>Traced through Hamburger to Dairy Farms
Authors: John S. Spika, Stephen H. Waterman, Guy W. Soo Hoo, Michael E. St. Louis, Richard E. Pacer, Susan M. James, Marjorie L. Bissett, Leonard W. Mayer, Joseph Y. Chiu, Betty Hall, Katherine Greene, Morris E. Potter, Mitchell L. Cohen, Paul A. Blake
Journal: New England Journal of Medicine (1987)

Animal-to-human transmission of drug-resistant salmonella and the role of antimicrobial use in food animals in the emergence of these bacteria are controversial subjects. Investigation of a 4.9-fold increase in Salmonella newport isolations from Californians in 1985 showed that 87 percent of the isolates had an unusual antimicrobial-resistance pattern (including chloramphenicol resistance) and a single, identical plasmid. Interviews of 45 patients and 89 matched controls in Los Angeles County showed that illness was associated with penicillin or tetracycline use during the month before onset (P less than 0.001) and with eating ground beef during the week before onset (P = 0.052). The epidemic strain was isolated from hamburger products eaten by cases, abattoirs where the animals from which the meat came were slaughtered, dairies that sent cows for slaughter on days when culture-positive products were processed, and ill dairy cows. Isolation of salmonella from beef carcasses in abattoirs correlated with the proportion of dead or moribund animals received for slaughter (r = 0.60, P less than 0.05). Isolation of chloramphenicol-resistant salmonella from dairy farms was associated with the use of chloramphenicol at those dairies. We conclude that food animals are a major source of antimicrobial-resistant salmonella infections in humans and that these infections are associated with antimicrobial use on farms.
A2.01 Increased soluble CD72 in systemic lupus erythematosus: A potential biomarker for disease activity and lupus nephritis
Authors: Z Vadasz, E Toubi
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Introduction</h3> Though of dual function, CD72 is appreciated for being a regulatory receptor on B cells. B cell receptor (BCR) -mediated signals are enhanced when CD72 expression is deficient on B cells in both animal models and autoimmune diseases such as systemic lupus erythematosus (SLE). The significance of soluble CD72 (sCD72) has not been elucidated. <h3>Methods</h3> We evaluated and compared the presence of sCD72 in the serum of patients with SLE and healthy individuals in order to ascertain whether sCD72 serum level is increased in SLE patients, using specific ELISA. Possible correlation was assessed between increased sCD72, SLE disease activity (SLEDAI), renal involvement and SLE related autoantibodies. <h3>Results</h3> The serum level of sCD72 in 159 SLE patients was found to be significantly increased compared to that of 80 healthy individuals (20 ± 1.2 ng/ml vs 8.2 ± 0.4 ng/ml; p &lt; 0.001). Soluble CD72 levels were significantly higher in patients positive for double –stranded DNA (dsDNA) antibodies than that in patients without (23±1.5ng\ml vs 14.1±1.4ng\ml; p=0.003), also for anti-cardiolipin Ab (aCL) (28.5±3.1ng\ml vs 15.2±1.8ng\ml; p &lt; 0.005); the levels were also significantly higher in patients with lupus nephritis than that in patients without (31.8 ± 2.3 ng/ml vs 13.9 ± 0.9 ng/ml; p &lt; 0.001). Finally, sCD72 correlated positively with SLE disease activity (r = 0.703; p &lt; 0.001). <h3>Conclusion</h3> Soluble CD72 is significantly increased in SLE patients. It is a possible marker for renal involvement, aCL and anti-dsDNA antibodies positivity in SLE and in positive correlation with SLE disease activity.
Effects of angiotensin II blockade in the canine puppy under different salt-intake
Authors: Theo J.W. Fiselier, Leo A.H. Monnens, Norbert H. Lameire, Piet J.J. van Munster, Petronella G.M. Peer, Isidoor R. Leusen, Paul J. Lijnen
Journal: Kidney International (1984)
Abstract 3729: Global and longitudinal analyses of demographic and clinico-pathological characteristics of triple-negative breast tumor tissues
Authors: Tony Brown, Aaron Moskalik, Nupur Pande, Elizabeth H. Peters, Stephanie Sullivan, Dalia Cohen
Journal: Cancer Research (2011)

Abstract Patients exhibiting triple-negative (ER-negative, PR-negative, HER2-) breast cancer pose a challenge to healthcare providers due to its relatively poor prognosis, aggressive tumor reoccurrence, and lack of targeted therapies. One critical resource that accelerates the molecular and pathophysiology of the triple-negative breast cancer subtype is the analyses of retrospectively collected, verified biospecimens. Unfortunately, limited availability of adequately annotated biospecimens as well as inconsistencies in clinical data that contradict pathology diagnosis can cause ambiguity in understanding demographic and clinico-pathological characteristics in patients. In this study, we systematically examined high quality-controlled and independently molecular and pathology verified breast tumor tissues collected from patients cases in Eastern Europe, Asia, and North America diagnosed with breast cancer between 2001 and 2010 to determine age-based distributions among pre-menopausal, menopausal, and post-menopausal women with triple-negative breast cancer. We defined the immunohistochemical (IHC) surrogates for the triple-negative subtype and assessed a total of 7,636 patients including 1,700 pre-menopausal patients (22%), 4,233 post-menopausal patients (55%), and 771 menopausal patients (10%). The average RNA RIN score was 8.3 across all samples. The median age at diagnosis was 56 (range 20-91 years). Results indicated that there was a decrease in ER expression with donor age, little to no change in PR or HER2 expression, and a progressively decreasing frequency of triple-negative with donor age. Our study demonstrates that independently verified and quality controlled biospecimens enable global and longitudinal analysis of demographic and clinico-pathological characteristics of patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3729. doi:10.1158/1538-7445.AM2011-3729
Rupture of the Interventricular Septum
Authors: Max J. Nareff, Leo J. Sklar, F. Tyler Kelly, James R. Reuling
Journal: New England Journal of Medicine (1950)

AMONG the complications that may plague the patient with myocardial infarction, there are few more dramatic or serious than rupture through an infarct involving the interventricular septum. To be sure, it is a rare phenomenon, but when it does occur the subsequent rapid course to termination frequently makes clinical detection difficult if not impossible. However, when time permits and one is aware of the syndrome, the antemortem diagnosis can readily be made.In 1845 the syndrome was first reported by Latham.1 There were occasional reports in the literature up to 1923, when Brunn2 described 2 cases and recorded the first . . .
Commentary: The Role of Nutrition in Mitigating Environmental Insults: Policy and Ethical Issues
Authors: Howard Hu, Sudha Kotha, Troyen Brennan
Journal: Environmental Health Perspectives (1995)

Research has accumulated which indicates that nutritional factors can significantly modify the host response to environmental toxicants.Correction of malnutrition can clearly mitigate the effects of many toxi- cants; however, evidence is mounting that supraphysiologic doses of nutrients (nutri- tional supplements) can further lessen toxicity.The use of dietary supplements, calcium in particular, to blunt the effects of lead is discussed as a case example.The possibility that nutrition could be implemented as a secondary prevention strategy on a public health scale raises important eth- ical and policy issues.The cost of cleaning up pollution when resources are scarce could favor secondary prevention strategies under a simple utilitarian analysis.This analysis, however, fails to recognize certain inequities such as the plight of those con- signed to suffer in polluted conditions.Nutritional strategies can lessen, but not abolish, toxic effects; moreover, they require dissemination and compliance, which are unlikely to be fully effective.These issues demonstrate the need to develop a public health paradigm for the role of nutritional interventions in environmental health.As our knowledge of environmental hazards grows, the threats they pose to