tbuckley/cabot-search huggingface dataset:
BM-10 * SYSTEMIC TREATMENT AND RADIATION NECROSIS FOLLOWING GKSRS IN THE TREATMENT OF BRAIN METASTASES
Authors: R. Colaco, P. Martin, J. Bond, R. Bindra, J. Contessa, H. Kluger, J. Yu, V. Chiang
Journal: Neuro-Oncology (2014)

INTRODUCTION: Based on anecdotal evidence from our institution, we sought to investigate the hypothesis that systemic therapy, and in particular newer immune therapy agents (IT) would increase the risk of developing radiation necrosis (RN) following stereotactic radiosurgery (SRS) with Gamma Knife (GK) for brain metastases (BM). METHODS: All patients undergoing GK at our institution between 2006 and 2012 were reviewed. 189 patients were identified of whom 183 survived more than 6 months. Details including type of systemic therapy (cytotoxic chemotherapy (CT), targeted therapy (TT) and immune therapy (IT) were recorded. Timing of ST in relation to GK was also recorded (before, during, less than 6 months and more than 6 months post GK). Logisitic regression was used to calculate the odds of developing RN by type of ST. RESULTS: Median follow up was 11.7 months. 42 patients (23%) developed RN of which 13 received IT alone. On univariate analysis, IT alone was associated with an increased risk of developing RN compared to CT alone (OR-2.44 [95%CI 1.02-5.79], p= 0.044) ) Multivariate analysis showed a trend towards an increased risk of RN with any IT (OR 1.9 {95%CI 0.91-3.99], p = 0.09) while receving any CT was found to be protective against RN (OR 0.39 [95% CI 0.19-0.79}, p = 0.009). CONCLUSION: Use of immune based therapies in patients receiving SRS for BM was associated with an increased risk of RN. Further investigation is needed to characterize these changes including to determine whether the increased rate of RN is due to a pro inflammatory effect of immune therapy or an interaction with radiation.
P3-05-08: Hormone Receptor Heterogeneity in Ductal Intraepithelial Neoplasia (Ductal Carcinoma In Situ) of the Breast.
Authors: M Sowden, C Flynn, V Bossuyt, D Lannin, AB Chagpar
Journal: Cancer Research (2011)

Abstract Background: Ductal Intraepithelial Neoplasia [DIN] often shows heterogeneity of both morphology and nuclear grade within the same patient. It is unknown whether this implies heterogeneity with respect to hormone receptor status that may affect treatment. We sought to determine the rate of heterogeneity in terms of nuclear grade and receptor status in DIN patients. Methods: A hospital tumor registry was queried for patients diagnosed with DIN between 1980 and 2010. Of the 746 patients identified, 579 (77.6%) had a concomitant invasive tumor. Of the remaining 167 patients, 70 were diagnosed prior to 2007 (when ASCO-CAP guidelines for hormone receptor measurements were released), 2 were found to have lobular intraepithelial neoplasia rather than DIN, and in 11 cases, pathology slides were not available for review. Of the 84 remaining patients with DIN, 17 (20.2%) had DIN 1 alone, 19 (22.6%) had DIN 2 alone, and 7 (8.3%) had DIN 3 alone. 41 (48.8%) of the patients had more than one grade of DIN. These patients formed the cohort of interest. Slides were reviewed by a single pathologist who evaluated ER and PR positivity within the different grades of DIN in each patient, classifying tumors staining 1% or greater as positive. Statistical analyses were performed using SPSS. Results: The median patient age was 53 years old. Of the 41 patients with multiple grades of DIN, 32 (78.0%) had DIN 1 and 2, 6 (14.6%) had DIN 2 and 3, and 3 (7.3%) had DIN 1, 2, and 3 within the same tumor. 93.8%, 94.7% and 88.9% of DIN 1, 2 and 3 lesions respectively were ER-positive. A difference in hormone receptor status between different grades of DIN within the same tumor was noted in 12 (29.3%) of patients; of these 3 (10.3%) varied in ER status and 10 (34.5%) varied in PR status. Of the 2 patients with ER-negative DIN 1, both had ER-positive higher grade DIN within the same tumor. Of the 2 patients with ER-negative DIN 2, one had ER-positive DIN 1 while the other had ER-negative DIN 3. Therefore, of the total 41 patients, 40 (97.6%) had at least one component of DIN that was ER-positive, and evaluating more than one grade of DIN for ER allowed 75% of patients with at least one ER-negative component to be offered hormonal therapy. Conclusions: Nearly 50% of patients with DIN will have more than one nuclear grade in the same tumor. These different nuclear grades vary in hormone receptor status in approximately 30% of patients. The majority of patients (97.6%) have at least one component of their DIN that is ER-positive. For those who have at least one component that is ER-negative, up to 75% may be offered hormonal therapy by considering other grades of DIN in treatment decision-making. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-05-08.
Acute Myeloid Leukemia in Children Treated with Epipodophyllotoxins for Acute Lymphoblastic Leukemia
Authors: Ching-Hon Pui, Raul C. Ribeiro, Michael L. Hancock, Gaston K. Rivera, William E. Evans, Susana C. Raimondi, David R. Head, Frederick G. Behm, M. Hazem Mahmoud, John T. Sandlund, William M. Crist
Journal: New England Journal of Medicine (1991)

Treatment of cancer with the epipodophyllotoxins (etoposide and teniposide) has been linked to the development of acute myeloid leukemia (AML) in children and adults, but the factors that might influence the risk of this complication of therapy are poorly defined. We therefore assessed the importance of potential risk factors for secondary AML in 734 consecutive children with acute lymphoblastic leukemia who attained complete remission and received continuation (maintenance) treatment according to different schedules of epipodophyllotoxin administration.
Brachial-Artery Bruits in Aortic-Valve Disease and Hypertrophic Subaortic Stenosis
Authors: Rex N. MacAlpin, Albert A. Kattus
Journal: New England Journal of Medicine (1965)

IN 1861 Duroziez1 described a double systolic-diastolic bruit that could be produced by compression of the femoral artery. This sign, present primarily in patients with aortic insufficiency, was found in other conditions such as typhoid fever, chlorosis and lead intoxication. Traube,2 eleven years later, noted a double sound heard in rare cases of aortic insufficiency with the stethoscope placed gently over the femoral artery without enough pressure to cause distortion of the vessel. In 1926 Bramwell and Hickson3 observed a double sound during systole over the brachial artery below a blood-pressure cuff inflated to nearly systolic pressure in some patients . . .
P954 PROTON PUMP INHIBITOR TREATMENT IS NEITHER ASSOCIATED WITH SPONTANEOUS BACTERIAL PERITONITIS DEVELOPMENT NOR WITH MORTALITY IN CIRRHOTIC PATIENTS WITH ASCITES
Authors: M. Mandorfer, S. Bota, P. Schwabl, T. Bucsics, C. Summereder, M. Hagmann, A. Blacky, A. Ferlitsch, W. Sieghart, M. Trauner, M. Peck-Radosavljevic, T. Reiberger
Journal: Journal of Hepatology (2014)
Werner's Syndrome
Authors: Jacob Schott, Sidney Dann
Journal: New England Journal of Medicine (1949)

OCCASIONALLY the opportunity of seeing one of the rarer disease states or syndromes presents itself to most physicians. Their recognition can be made more readily possible if those who see them bring them to the attention of the profession.Our purpose in this paper is to add 2 more cases of Werner's syndrome to the literature, to review briefly the more pertinent features of the syndrome and to outline the criteria in as simple a manner as possible, so that they can be easily remembered. Thannhauser,§ in 1945, added 5 cases to the literature and in a most excellent article . . .
621 EVALUATION OF A NEW BALLOON OCCLUSION CATHETER DESIGNED FOR HVPG MEASUREMENT
Authors: A. Ferlitsch, P. Salzl, B. Heinisch, B. Payer, T. Reiberger, W. Sieghart, K. Reinhart, M. Peck-Radosavljevic, M. Ferlitsch
Journal: Journal of Hepatology (2012)
Intense Muscle Uptake of Tc-99m MDP and Ga-67 Citrate in Massive Rhabdomyolysis
Authors: I. PROVAN C. MURRAY, VICTOR J. MANSBERG, MONICA A. ROSSLEIGH
Journal: Clinical Nuclear Medicine (1997)

A 6-year-old boy had an Addisonian crisis with hyponatremic shock and required resuscitation after cardiac arrest. Severe renal failure necessitated continuous dialysis. Rhabdomyolysis was identified because of myoglobinuria and gross elevation of creatinine kinase. In the course of his treatment, bone infection was suspected. A bone scan with Tc-99m MDP showed intense uptake in numerous major muscle groups throughout the body in keeping with massive rhabdomyolysis. Similar gross muscle uptake of Ga-67 citrate was less expected. In an additional bone scan obtained 15 days later, the MDP uptake showed less intense accumulation.
PTH-115 Inhibition of mapk signalling promotes cell cycle arrest and sensitises intrahepatic cholangiocarcinoma cells to chemotherapy
Authors: PM Choy, J Sufi, S Glaser, G Alpini, N Heaton, R Williams, A Quaglia, W-K Syn, C Bubici, S Papa
Journal: Gut (2015)

<h3>Introduction</h3> Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy, accounting for approximately 15% of cases of primary liver cancer. Although new treatments have increased survival for many other cancers, including the more common primary hepatocellular carcinoma, treatment strategies and survival for patients with ICC have seen little improvement. Our previous studies suggest that the mitogen-activated protein kinase (MAPK) signalling plays a central role in the regulation of cell proliferation in human ICC. However the molecular mechanisms are poorly understood. In this study, we aim to explore whether inhibition of the MAPK pathway and its downstream effectors enhances the sensitisation of ICC cells to the chemotherapeutic agent cisplatinum. <h3>Method</h3> We used a combinatorial approach of immunohistochemical and gene expression analyses to investigate the expression of MAPK-related genes in ICC tumours. Furthermore, by using <i>in-vitro</i>and <i>in-vivo</i>analyses we have characterised the function of a novel MAPK downstream effector in ICC cells. <h3>Results</h3> The expression of MAPK signalling was determined by immunohistochemical staining in tumour samples from a cohort of 14 ICC patients. High expression of phospho-activated MAPK was observed in 71.4% (10/14) of ICC cases as compared with surrounding nontumour tissue. Likewise, expression of JDP, a downstream effector of the MAPK signalling, was scored as high intensity in 64.3% (9/14). Strikingly, elevated expression of JDP transcripts was also observed in two independent cohorts of human ICC (n = 149 and n = 109 per group, respectively) compared to surrounding normal liver tissue. Consistent with the in-vivo analyses of human samples, immunoblotting analyses showed constitutive activation of MAPK and expression of JDP in ICC-derived cells (i.e. SG231, CCLP-1 and HuCCT1). Using loss-of-function analyses, we demonstrates that knockdown of JDP in ICC-derived cells resulted in cell cycle arrest and reduced expression of cell cycle regulators (i.e. cyclins), and had minimal effect on apoptosis. Chemical inhibition of JDP significantly sensitises ICC-derived cells to cisplatinum (P &lt; 0.001). <h3>Conclusion</h3> These results demonstrate that enhanced activation of MAPK signalling is important for ICC cell proliferation and suggest that targeting its downstream effectors is a potential therapeutic strategy for ICC. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> This abstract is funded by Alan Morement Memorial Fund
Abstract 3182: PTM ELISA microarray for breast cancer biomarker discovery
Authors: Hongjun Jin, Don S. Daly, Ruimin Tan, Amanda M. White, Jeffrey R. Marks, Richard C. Zangar
Journal: Cancer Research (2011)

Abstract Post-translational modifications (PTMs) of proteins are known to be altered during breast cancer development. These PTMs are potentially useful biomarkers for breast cancer. In order to study the potential of PTMs in the early detection of breast cancer, ELISA microarray protocols for analyzing several PTMs in a panel of 24 proteins that are found in blood but known to be secreted by breast tissue and/or breast tumors. We evaluated these PTMs in a case-control study with 68 plasma samples. The control samples were from age-matched women with benign breast disease. The sensitivity and the specificity of each assay and the combined assays were evaluated using the areas under (AUC) the receiver operator curves. In the best multivariate analysis, the AUC values ranged from 77% to 87% for 4 different PTMs. Overall, our data suggest that the PTM ELISA microarray platform is a promising tool for discovery and evaluation of biomarkers that have potential for the early detection of breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3182. doi:10.1158/1538-7445.AM2011-3182
Apport clinique de la capsule colique chez des patients en échec ou contre-indication de coloscopie: résultats du suivi à un an des patients
Authors: M Pioche, A de Leusse, B Filoche, PA Dalbiès, P Adenis Lamarre, P Jacob, JL Gaudin, P Coulom, JC Létard, E Borotto, A Duriez, JM Chabaud, D Crampon, R Gincul, P Lévy, E Ben Soussan, M Garret, J Lapuelle, JC Saurin
Journal: Endoscopy (2012)

Environ 5% des coloscopies en France sont incomplètes pour des raisons techniques ou contreindiquées sur le plan anesthésique. Nous rapportons le suivi sur un an de patients examinés par vidéocapsule colique (Given Imaging°) dans cette situation.
The Constitutionality of the ACA's Medicaid-Expansion Mandate
Authors: I. Glenn Cohen, James F. Blumstein
Journal: New England Journal of Medicine (2011)

Interview with I. Glenn Cohen on the constitutional challenge of the Affordable Care Act that will be heard by the United States Supreme Court in March. (19:17)Download The Supreme Court has promised to review not only the constitutionality of the Affordable Care Act's individual mandate but also the issue, raised by Florida and 25 other states, of whether the ACA's Medicaid expansion violates the U.S. Constitution.
SAT0250 Validation of a New Scoring Method for the Evaluation of Fat Lesions in the Spine of Patients with Axial Spondyloarthritis: The Canada-Denmark Fat Spondyloarthritis Spine Score (FASSS)
Authors: S. J. Pedersen, Z. Zhao, R. G. Lambert, M. Østergaard, U. Weber, W. P. Maksymowych
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Fat lesions (FL) have been shown to follow resolution of inflammation in the spine of patients with axial spondyloarthritis (SpA) (1), and to predict development of new syndesmophytes (2). Thus, scoring of FLs in the spine may constitute both an important measure of treatment efficacy and a surrogate marker for new bone formation. <h3>Objectives</h3> To develop and validate a new scoring method for FLs in the spine, the CanDen Fat SpA Spine Score (FASSS), which addresses the localization and phenotypic diversity of FLs in SpA. <h3>Methods</h3> The fat scoring method comprises different types of FLs, which are defined according to their anatomical location and are recorded dichotomously (present/absent) at each vertebral endplate (from C2 lower to S1 upper) according to the definitions of the Canada-Denmark MRI working (3). The scoring range per disco-vertebral unit (DVU) for the cervical (C) spine is 0-8, and for the thoracic (T) and lumbar (L) spine is 0-24, resulting in a total scoring range of 0-456 for all 23 DVUsTwo rheumatologists evaluated MRI scans obtained at two time points (mean 1.5 years (SD 0.5)) in chronological order of 67 patients (exercise 1). After exercise 1 the scoring methodology and reference image set were revised based on discrepant cases. In a nested case study design, the two readers re-read 30 randomly selected pairs of MRI scans from the first exercise together with 40 new pairs of MRI scans (exercise 2) (mean 1.7 years (SD: 0.8)). <h3>Results</h3> In exercise 2, the change in fat scores ranged from -33 to 48 for reader A and from -38 to 54 for reader B. Inter-observer ICC scores were high to very high for the FASSS baseline scores, and improved substantially in change scores from exercise 1 to 2 (Table). Inter-observer intra-class correlation coefficients (ICCs) for baseline scores were high for all spinal segments, and change scores improved from small to moderate for the C spine, from moderate to high for the L spine and remained very high for the T spine. This was particularly notable for the 30 patients evaluated in both exercises. <h3>Conclusions</h3> The FASSS therefore meets essential validation criteria for further assessment in axial SpA, and for follow-up of SpA in clinical trials and practice. <h3>References</h3> Chiowchanwisawakit et al. ARD 2010; Chiowchanwisawakit et al. AR 2011; Østergaard et al. J Rheum 2009 <h3>Disclosure of Interest</h3> None Declared
SP0109 Quality of Care and Telemonitoring, the Added Value of ICT in Daily Care and Registries
Authors: M.A. Van De Laar
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> The impact of rheumatic diseases on quality of life is impressive. Functional impairment, productivity loss, and healthcare costs due to rheumatic disease belong to the top. The introduction of biologicals especially TNF blockers have changed the disease outcome of our patients. Evenmore, improved treatment strategies, aiming at induction of remission, stable remission and drug free remission have changed the prognosis of patients. New indications and new targets for innovative medications have on the one hand changed the focus of rheumatology from care to cure, but on the other hand have changed or health care from high volume low costs care to high volume high costs. In the good tradition of Hippocrates each physician aims the best for his patients. However, can the patient be sure that his physician is providing the best quality of care? And when high costs are involved can the payer be sure that quality of care is in balance with costs? Finally, has the health professional access to feedback to be sure that he is providing the best care to actual standards? As we speak in many healthcare systems transparency of quality of care is aimed for in low volume high costs care, like oncology. Some systems are already running for many years and common problems are: manpower, costs, privacy and insufficient interaction between, patient, professional and registry. In rheumatology/immunology especially the introduction of biologicals has led to registries of patients using these expensive drugs. All registries have problems with quality and completeness of data. The experiences with registries have taught that where RCTs can reveal and illustrate the efficacy of interventions, only phase 4 registries are able to reveal effectiveness of interventions. In the Netherlands rheumatologists have initiated a registry for RA patients called the DREAM registry. This registry has initiated collaboration with the technical University of Twente resulting in a ICT supported system, where in day-to-day healthcare, professionals, patients and phase 4 registries are combined. The system supports each group resulting in patients having access to their individual dossier; professionals having an overview of quality of care in individual patients but also of the quality of care of his clinic and benchmark information. Finally the system provides the information necessary for phase 4 resaerch including healtheconomical analysis. In this lecture the principle components of the system will be shown and explained. The introduction of contemporary tailor-made software applications as resulted in the extension of the DREAM registry form RA to multiple indications in rheumatology. <h3>Disclosure of Interest</h3> M. Van De Laar Shareholder of: Transparency-in-Healthcare bv <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6123
REFLECTION MAGNITUDE, A MEASURE OF ARTERIAL STIFFNESS, PREDICTS INCIDENT CONGESTIVE CONGESTIVE HEART FAILURE IN MEN BUT NOT WOMEN: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Authors: Rebecca Chester, Tamara Horwich, Preethi Srikanthan, Jeffrey Gornbein, Gregory Hundley, Karol Watson
Journal: Journal of the American College of Cardiology (2016)
OP0076-HPR Effects of a soft thumb base splint in persons with carpometacarpal osteoarthritis: A randomised controlled trial
Authors: M. Hermann, T. Nilsen, C. Støyva Eriksen, I. Haugen, B.S. Christensen, I. Kjeken
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Hand osteoarthritis (HOA) typically involves the distal interphalangeal joints the proximal interphalangeal joints, and the first carpometacarpal (CMC1) joint. Common functional consequences are pain, reduced hand mobility and grip force, and limitation in performance of daily activities. Carpometacarpal osteoarthritis (CMC1-OA) affect 5% of women over age 70 years and no disease-modifying intervention is available. <h3>Objectives</h3> To assess the effectiveness, regarding pain, hand strength, function in daily activities of a prefabricated soft splint for persons with osteoarthritis of the CMC1-joint. <h3>Methods</h3> In this randomised controlled trial, 59 persons with CMC1-OA were included. The control-group (n=29) received hand exercises and the splint-group (n=30) received hand exercises and splint. The following assessments were performed at baseline and after 2 months: Grip- and pinch strength in Newton (N) were measured with Grippit. Pain during resisted grip was measured on a numeric rating scale (NRS) (0=no pain). Thumb web-space was measured with Gripsize and joint mobility was recorded in millimetre (mm). Self-reported hand function was assessed with AUSCAN on five point Likert scales (0=no problem). Patients were recommended to perform hand exercises twice a day and the splint-group were instructed to wear the splint when having pain and/or when performing heavier manual tasks. At two months we also measured grip strength and pain both with and without splint in the splint-group and conducted a semi-structured interview were we asked splint-group about their experience with the splint. <h3>Results</h3> The mean age of the participants was 70.5 years (SD 6.7), mean disease duration was 15.2 years, and one third had CMC-OA grade 3 or more. Nine participants were provided with a splint for their right thumb, 4 for left thumb and 17 participants for both thumbs. There were no significant differences between the groups in any outcome after two months. In the splint-group, pain during resisted grip was significant less when wearing the splint compared to without. Most participants were satisfied with the splint and reported the splint as useful, especially during household management. <h3>Conclusions</h3> The results indicate that a soft prefabricated splint has an immediate pain- relieving when worn, but no long term effect in terms of reduced inflammation and pain, or improved strength or activity performance in patients with CMC1-OA. <h3>Disclosure of Interest</h3> None Declared
99mTc-MIBI Emboli in the Lungs Detected on SPECT/CT
Authors: Mustafa Aras, Tanju Yusuf Erdil, Tunc Ones, Fuat Dede, Halil Turgut Turoglu
Journal: Clinical Nuclear Medicine (2013)

Although we are familiar with artifactual, focal pulmonary F-FDG accumulations without an apparent underlying pathologic finding, similar artifact for Tc-MIBI has not been described yet. Herein, we reported incidental detection of Tc-MIBI emboli in the lungs on parathyroid SPECT/CT.
Aerosolized Surfactant in Adults with Sepsis-Induced Acute Respiratory Distress Syndrome
Authors: Antonio Anzueto, Robert P. Baughman, Kalpalatha K. Guntupalli, John G. Weg, Herbert P. Wiedemann, Antoni Artigas Raventós, François Lemaire, Walker Long, David S. Zaccardelli, Edward N. Pattishall
Journal: New England Journal of Medicine (1996)

Patients with acute respiratory distress syndrome (ARDS) have a deficiency of surfactant. Surfactant replacement improves physiologic function in such patients, and preliminary data suggest that it may improve survival.