tbuckley/cabot-search huggingface dataset:
The Course of Bone Marrow Edema in Early Undifferentiated Arthritis and Rheumatoid Arthritis: A Longitudinal Magnetic Resonance Imaging Study at Bone Level
Authors: Wouter P. Nieuwenhuis, Hanna W. van Steenbergen, Wouter Stomp, Theo Stijnen, Tom W. J. Huizinga, Johan L. Bloem, Désirée van der Heijde, Monique Reijnierse, Annette H. M. van der Helm‐van Mil
Journal: Arthritis & Rheumatology (2015)

Objective In patients with rheumatoid arthritis (RA), bone marrow edema (BME) scores are associated with development of erosions. However, little is known about the course and outcome of BME at bone level. We undertook this study to determine the association of BME and synovitis with the development of erosions in the same bone longitudinally. Methods Using 1.5T magnetic resonance imaging at baseline and at 4‐ and 12‐month follow‐up, we studied 1,947 bones of the metacarpophalangeal, wrist, and metatarsophalangeal joints in 59 patients presenting with RA or undifferentiated arthritis. Scanning and scoring of BME, synovitis, and erosions were performed according to the Outcome Measures in Rheumatology Rheumatoid Arthritis Magnetic Resonance Imaging Scoring system. We evaluated the relationship of the course of BME and synovitis with erosive progression at bone level during 1 year. Results Of the bones showing BME at baseline (n = 203), BME persisted in 56%, disappeared in 39%, and disappeared and then reappeared in 5%. Stratified analyses at baseline revealed that BME was associated with erosive progression both in the presence and in the absence of local synovitis, with odds ratios (ORs) of 7.5 (95% confidence interval [95% CI] 3.8–14.9) and 6.9 (95% CI 1.9–25.6), respectively. However, local synovitis was not associated with erosive progression in the presence or in the absence of BME (ORs of 2.0 [95% CI 0.6–7.0] and 1.9 [95% CI 0.8–4.1], respectively). In multivariable generalized estimating equation analyses, persistent BME was strongly associated with erosive progression (OR 60.5 [95% CI 16.8–218.1]) in contrast to persistent synovitis (OR 1.3 [95% CI 0.4–4.4]). Conclusion BME frequently persists during the first year. Persistent BME was strongly associated with erosive progression in the same bone, independently of local synovitis. No independent association was observed for persistent synovitis. These findings are relevant for comprehending the development of erosions in RA.
Fish Intake During Pregnancy and Offspring Adiposity—Reply
Authors: Nikos Stratakis, Maurice P. Zeegers, Leda Chatzi
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
153P Novel, highly sensitive molecular biomarkers for metastatic colorectal cancer
Authors: G. Takahashi, T. Yamada, H. Kan, S. Matsumoto, M. Koizumi, S. Shinji, A. Matsuda, Y. Yokoyama, T. Iwai, Y. Masuda, A. Watanabe, E. Uchida
Journal: Annals of Oncology (2015)
Measurement of Urinary Endothelin-1-Like Immunoreactivity and Comparison with Other Urinary Parameters in Patients with Primary Vesicoureteral Reflux
Authors: Masayuki Taleda, Takeshi Komeyama, Yasushi Katayama, Toshiki Tsutsui, Takako Mizusawa, Hitoshi Takahashi, Akihiko Hatano, Kenji Obara, Shotaro Sato
Journal: European Urology (1994)
Pattern of Inpatient Laxative Use
Authors: Todd C. Lee, Emily G. McDonald, Andre Bonnici, Robyn Tamblyn
Journal: JAMA Internal Medicine (2016)

magazines, medical center advertising for cancer services unless a specific cancer center was mentioned, or charitable promotions placed by affiliated organizations.For example, City of Hope, a leading cancer center in Duarte, California, was recently highlighted in The New York Times for millions of dollars in annual health care advertising. 5According to Kantar Media, that advertising was to promote donations to City of Hope and was not placed by the cancer center.Our search strategy did not capture such promotional spending.For some patients and families, cancer-center advertising may constitute a major source of information, raising concerns in view of evidence that the content of some advertising lacks balance. 4Spending on advertising is not a measure of quality of care, 6 and physicians and cancer-care organizations should help patients make informed cancer treatment decisions.The effect of cancercenter advertising on the quality and costs of cancer care should be better understood.
Factors associated with undiagnosed and overdiagnosed COPD
Authors: Andrea S. Gershon, Jeremiah Hwee, Kenneth R. Chapman, Shawn D. Aaron, Denis E. O'Donnell, Matthew B. Stanbrook, Jean Bourbeau, Wan Tan, Jiandong Su, J. Charles Victor, Teresa To
Journal: European Respiratory Journal (2016)

Worldwide, studies have shown that about 60–86% of people with chronic obstructive pulmonary disease (COPD) have not been diagnosed, which represents a missed opportunity to decrease disease burden through optimal management, including smoking cessation support and prescription medications [1–3]. Overdiagnosed COPD is also common, with prevalence estimates ranging from 4% to 64% in the general population and primary care settings [4, 5]. Overdiagnosis can lead to unnecessary COPD treatments with their own risks and costs, poor health-related quality of life and missed detection and treatment of other diseases [6]. Several factors are associated with undiagnosed and overdiagnosed COPD <http://ow.ly/4mW6lu> Parts of this material are based on data and information compiled and provided by the Canadian Institute for Health Information (CIHI). However, the analyses, conclusions, opinions and statements expressed herein are those of the authors, and not necessarily those of CIHI. Author contributions were as follows. A.S. Gershon, J. Hwee, J.C. Victor and T. To conceived and designed the study. A.S. Gershon, J. Hwee and J.C. Victor acquired the health administrative data and D.E. O'Donnell, K.R. Chapman, S.D. Aaron, J. Bourbeau and W. Tan acquired the clinical data. All authors designed the study. J. Hwee and J. Su carried out the statistical analysis. All authors interpreted the data. A.S. Gershon and J. Hwee drafted the manuscript. All authors critically revised the manuscript for important intellectual content and approved the submitted version. A.S. Gershon obtained funding. A.S. Gershon, J. Hwee and J.C. Victor were involved in administrative support. A.S. Gershon, J. Hwee and J. Su had full access to all the data in the study and take responsibility for the integrity of the data and accuracy of the analysis. A.S. Gershon is guarantor.
Excellence in Medicine and the Case for Aspirational Ethics
Authors: Jonathan Kantor, Boris D. Lushniak
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Metabolism of N&lt;sup&gt;15&lt;/sup&gt;-Labeled &lt;italic&gt;p&lt;/italic&gt;-Dimethylaminoazobenzene in Rats
Authors: M. Berenbom, J. White
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Metabolism of N15-Labeled p-Dimethylaminoazobenzene in Rats Get access M. Berenbom, M. Berenbom National Cancer Institute, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. White J. White National Cancer Institute, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 3, December 1951, Pages 583–590, https://doi.org/10.1093/jnci/12.3.583 Published: 01 December 1951 Article history Received: 12 September 1951 Published: 01 December 1951
Cadaver Exome Sequencing for Teaching First-Year Medical Students—Reply
Authors: Glenn S. Gerhard, Barbara Paynton, Steven N. Popoff
Journal: JAMA (2016)

In Reply We could only briefly highlight key ethical issues pertaining to the use of exome sequence data obtained from individuals who have donated their bodies for teaching anatomy to medical students in our Viewpoint, which Dr Cornwall and colleagues have described in more detail.
Bendamustine in Combination With Gemcitabine and Vinorelbine Is an Effective Regimen As Induction Chemotherapy Before Autologous Stem-Cell Transplantation for Relapsed or Refractory Hodgkin Lymphoma: Final Results of a Multicenter Phase II Study
Authors: Armando Santoro, Rita Mazza, Alessandro Pulsoni, Alessandro Re, Maurizio Bonfichi, Vittorio Ruggero Zilioli, Flavia Salvi, Francesco Merli, Antonella Anastasia, Stefano Luminari, Giorgia Annechini, Manuel Gotti, Annalisa Peli, Anna Marina Liberati, Nicola Di Renzo, Luca Castagna, Laura Giordano, Carmelo Carlo-Stella
Journal: Journal of Clinical Oncology (2016)

This multicenter, open-label, phase II study evaluated the combination of bendamustine, gemcitabine, and vinorelbine (BeGEV) as induction therapy before autologous stem-cell transplantation (ASCT) in patients with relapsed or refractory Hodgkin lymphoma (HL).Patients with HL who were refractory to or had relapsed after one previous chemotherapy line were eligible. The primary end point was complete response (CR) rate after four cycles of therapy. Secondary end points were: overall response rate, stem-cell mobilization activity, and toxicity. Progression-free and overall survival were also evaluated.In total, 59 patients were enrolled. After four cycles of therapy, 43 patients (73%) achieved CR, and six (10%) achieved partial response, for an overall response rate of 83%. The most common grade 3 to 4 nonhematologic toxicities included febrile neutropenia (n = 7) and infection (n = 4). Regarding hematologic toxicities, grade 3 to 4 thrombocytopenia and neutropenia were each experienced by eight patients (13.5%). CD34+ cells were successfully harvested in 55 of 57 evaluable patients, and 43 of 49 responding patients underwent ASCT. With a median follow-up of 29 months, the 2-year progression-free and overall survival rates for the total population were 62.2% and 77.6%, respectively. The same figures for patients undergoing autograft were 80.8% and 89.3%, respectively.This phase II study demonstrates that BeGEV is an effective salvage regimen able to induce CR in a high proportion of patients with relapsed or refractory HL before ASCT. These data provide a strong rationale for further development of the BeGEV regimen.
Soundings: On reading Proust
Authors: George Dunea
Journal: BMJ (2006)

“Your grandmother is doomed,” says the doctor in Marcel Proust's semi-autographical masterpiece. “It is a stroke brought on by uremia. In itself uremia is not necessarily fatal, but this case seems to me hopeless...”The doctor is impatient, for he is an important man and has an appointment with the minister. There were no blood tests at that time, but the old lady takes to her bed and dies in considerable detail over the course of many pages.

Reading Proust is indeed a marathon. This is illustrated by the young man who began to read him in his teens. He read continuously, interrupted only for meals, firstly by his mother, later by his wife, then successively by his daughter, his granddaughter, and at last by the nurse in a retirement home. It is an appropriate story, because Remembrance of Things Past goes on for a long time. So hurrah for modern technology. It has produced 39 CDs that can be listened to on the way to work in about two months.

By now hundreds of critics have admired Proust's style, commented on the psychology of this complex creature, and on his description of the pains and pleasures of the “inverts” (having arbitrarily decided that the men sinned in Sodom, the women in Gomorrah), his complicated love affairs, and his descriptions of fin de siecle salons.

In her better days the grandmother was no more compliant than her modern counterparts, for as the doctor “called in to cope with a sudden feverish attack... and wrote out various prescriptions...my grandmother took these with a show of respect in which I could at once discern her firm resolves to ignore them all.”

In society we meet Dr Cottard, a “more brilliant diagnostician than Potain,” praised by everyone “for the quickness, the unerring judgment of his diagnoses,” shy but compensating by assuming a repellent coldness, recommending sea voyages, or, more drastically, “purges, violent and drastic purges; milk for some days, nothing but milk. No meat. No alcohol,” regardless of the patient's underlying condition.

The last chapters are about old age, when, released from a sanitarium, the narrator finds his old acquaintances white haired, some grossly obese, others shrivelled and bent over. Often he does not recognise them. Even the doctor has become old.
Case 17-1964
Authors: Samuel R. Schuster, Benjamin Castleman
Journal: New England Journal of Medicine (1964)

Presentation of Case* First admission. A five-year-old white boy was admitted to the hospital because of abdominal pain.The child had been well until three months previously, when he began to experience recurrent episodes of dull, generalized pain in the abdomen. Three weeks before entry he was admitted to another hospital because of a sharp, crampy pain in the right groin. An exploratory operation revealed an undescended right testicle associated with a hernial sac containing blood; organizing hematomas within the omentum and the gastrocolic ligament and a "phlegmon" involving the pancreas were found. The amylase level was normal. The patient . . .
Morbid Anatomy, Histopathology, and Histopathogenesis of Forestomach Carcinoma in Mice Fed Carcinogenic Hydrocarbons in Oil Emulsions
Authors: Harold L. Stewart, Egon Lorenz
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article Morbid Anatomy, Histopathology, and Histopathogenesis of Forestomach Carcinoma in Mice Fed Carcinogenic Hydrocarbons in Oil Emulsions Get access Harold L. Stewart, Harold L. Stewart National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Egon Lorenz Egon Lorenz National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 147–166, https://doi.org/10.1093/jnci/10.1.147 Published: 01 August 1949 Article history Received: 16 May 1949 Published: 01 August 1949
Cancer immunotherapy trials: leading a paradigm shift in drug development
Authors: Leisha A. Emens, Lisa H. Butterfield, F. Stephen Hodi, Francesco M. Marincola, Howard L. Kaufman
Journal: Journal for ImmunoTherapy of Cancer (2016)

Cancer immunotherapy has a long history in the clinic. William Coley was an orthopedic surgeon in the late 1800's who noted marked tumor regression in a patient with severe erysipelas. Based on this observation, he hypothesized that stimulating the immune system could effectively treat cancer.
Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia
Authors: Margherita Ghisi, Lev Kats, Frederick Masson, Jason Li, Tobias Kratina, Eva Vidacs, Omer Gilan, Maria A. Doyle, Andrea Newbold, Jessica E. Bolden, Kirsten A. Fairfax, Carolyn A. de Graaf, Matthew Firth, Johannes Zuber, Ross A. Dickins, Lynn M. Corcoran, Mark A. Dawson, Gabrielle T. Belz, Ricky W. Johnstone
Journal: Cancer Cell (2016)
The induction of transplantation tissue tolerance requires Foxp3 expression
Authors: F S Regateiro, Y Chen, A R Kendal, R Hilbrands, E Adams, J Ma, K G Andersen, A G Betz, S Hori, M Zhang, S Madhiwalla, B Roberts, S P Cobbold, K F Nolan, D Howie, H Waldmann
Journal: Allergy (2013)
Selenium and Prostate Cancer: Analysis of Individual Participant Data From Fifteen Prospective Studies
Authors: Naomi E. Allen, Ruth C. Travis, Paul N. Appleby, Demetrius Albanes, Matt J. Barnett, Amanda Black, H. Bas Bueno-de-Mesquita, Mélanie Deschasaux, Pilar Galan, Gary E. Goodman, Phyllis J. Goodman, Marc J. Gunter, Markku Heliövaara, Kathy J. Helzlsouer, Brian E. Henderson, Serge Hercberg, Paul Knekt, Laurence N. Kolonel, Christina Lasheras, Jakob Linseisen, E. Jeffrey Metter, Marian L. Neuhouser, Anja Olsen, Valeria Pala, Elizabeth A. Platz, Harri Rissanen, Mary E. Reid, Jeannette M. Schenk, Meir J. Stampfer, Pär Stattin, Catherine M. Tangen, Mathilde Touvier, Antonia Trichopoulou, Piet A. van den Brandt, Timothy J. Key
Journal: JNCI Journal of the National Cancer Institute (2016)

Background: Some observational studies suggest that a higher selenium status is associated with a lower risk of prostate cancer but have been generally too small to provide precise estimates of associations, particularly by disease stage and grade. Methods: Collaborating investigators from 15 prospective studies provided individual-participant records (from predominantly men of white European ancestry) on blood or toenail selenium concentrations and prostate cancer risk. Odds ratios of prostate cancer by selenium concentration were estimated using multivariable-adjusted conditional logistic regression. All statistical tests were two-sided. Results: Blood selenium was not associated with the risk of total prostate cancer (multivariable-adjusted odds ratio [OR] per 80 percentile increase = 1.01, 95% confidence interval [CI] = 0.83 to 1.23, based on 4527 case patients and 6021 control subjects). However, there was heterogeneity by disease aggressiveness (ie, advanced stage and/or prostate cancer death, Pheterogeneity = .01), with high blood selenium associated with a lower risk of aggressive disease (OR = 0.43, 95% CI = 0.21 to 0.87) but not with nonaggressive disease. Nail selenium was inversely associated with total prostate cancer (OR = 0.29, 95% CI = 0.22 to 0.40, Ptrend < .001, based on 1970 case patients and 2086 control subjects), including both nonaggressive (OR = 0.33, 95% CI = 0.22 to 0.50) and aggressive disease (OR = 0.18, 95% CI = 0.11 to 0.31, Pheterogeneity = .08). Conclusions: Nail, but not blood, selenium concentration is inversely associated with risk of total prostate cancer, possibly because nails are a more reliable marker of long-term selenium exposure. Both blood and nail selenium concentrations are associated with a reduced risk of aggressive disease, which warrants further investigation.
Clonal circulation of Salmonella enterica serotype Heidelberg in Italy?
Authors: C Mammina, M Talini, M Pontello, A M Di Noto, A Nastasi
Journal: Eurosurveillance (2003)

Phenotypic and genetic characteristics of 21 strains of Salmonella serotype Heidelberg isolated in the years 1999-2003 from different sources in Italy were studied. Susceptibility patterns, plasmid analysis, and PFGE were used as epidemiological markers. Although non-homogeneous drug resistance patterns and plasmid profiles had been detected, PFGE patterns suggest the hypothesis of a nationwide clonal spread of this serotype associated with poultry.
Incidence and Clinical Features of Extramedullary Multiple Myeloma in Patients Who Underwent Stem Cell Transplantation
Authors: Matthew Weinstock, Yosra Aljawai, Irene M. Ghobrial, Elizabeth A. Morgan, Jacob P. Laubach, Aldo M Roccaro, Cindy Varga, Muriel Gannon, Claudia E. Paba-Prada, Robert L Schlossman, Nikhil Munshi, Kenneth C. Anderson, Paul G. Richardson, Constantine S. Mitsiades
Journal: Blood (2014)
Lung Volume Reduction Coils for Severe Emphysema
Authors: Thiago A. Jabuonski, Donald R. Lazarus
Journal: JAMA (2016)

To the Editor The REVOLENS trial1 found that bronchoscopic treatment with nitinol coils vs usual care improved exercise capacity in patients with severe emphysema and adds to the growing literature on endobronchial treatment of emphysema.2,3
Semisynthetic Taxol Goes on Market Amid Ongoing Quest For New Versions
Authors: C McNeil
Journal: JNCI Journal of the National Cancer Institute (1995)

Semisynthetic Taxol Goes on Market Amid Ongoing Quest For New Versions Get access JNCI: Journal of the National Cancer Institute, Volume 87, Issue 15, 2 August 1995, Pages 1106–1108, https://doi.org/10.1093/jnci/87.15.1106 Published: 02 August 1995