tbuckley/cabot-search huggingface dataset:
Mechanical Ventilation to Minimize Progression of Lung Injury in Acute Respiratory Failure
Authors: Laurent Brochard, Arthur Slutsky, Antonio Pesenti
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Mechanical ventilation is used to sustain life in patients with acute respiratory failure. A major concern in mechanically ventilated patients is the risk of ventilator-induced lung injury, which is partially prevented by lung-protective ventilation. Spontaneously breathing, nonintubated patients with acute respiratory failure may have a high respiratory drive and breathe with large tidal volumes and potentially injurious transpulmonary pressure swings. In patients with existing lung injury, regional forces generated by the respiratory muscles may lead to injurious effects on a regional level. In addition, the increase in transmural pulmonary vascular pressure swings caused by inspiratory effort may worsen vascular leakage. Recent data suggest that these patients may develop lung injury that is similar to the ventilator-induced lung injury observed in mechanically ventilated patients. As such, we argue that application of a lung-protective ventilation, today best applied with sedation and endotracheal intubation, might be considered a prophylactic therapy, rather than just a supportive therapy, to minimize the progression of lung injury from a form of patient self-inflicted lung injury. This has important implications for the management of these patients.
P2-038: VEGFR1-2, C-Kit, HER2 and CD20 immunostaining in thymic epithelial tumors staged according to the WHO.
Authors: Benjamin Besse, Estelle Taranchon, Pierre Validire, Elisabeth Brambilla, Philippe Girard, Philippe Dartevelle, Pierre Ruffié, Cécile Le Pechoux, Jean Charles Soria, Vincent De Montpreville
Journal: Journal of Thoracic Oncology (2007)
P2-029: The role of gene mutations and amplifications involved in epidermal growth factor receptor pathways in non-small cell lung cancer
Authors: Kazuya Takamochi, Koji Okudera, Shinji Kageyama, Tomoyasu Bunai, Hiroshi Niwa, Hiroshi Ogawa, Kazuya Suzuki, Haruhiko Sugimura
Journal: Journal of Thoracic Oncology (2007)
Long-term neurocognitive development of critically ill children 4 years after randomization to insulin-titrated age-adjusted normoglycemia or to usual care
Authors: Dieter Mesotten, Marijke Gielen, Caroline Sterken, Dirk Vlasselaers, Greet Hermans, Ilse Vanhorebeek, Pieter Wouters, Greet Van den Berghe
Journal: Endocrine Reviews (2012)
Different activation signals induce distinct mast cell degranulation strategies
Authors: Nicolas Gaudenzio, Riccardo Sibilano, Thomas Marichal, Philipp Starkl, Laurent L. Reber, Nicolas Cenac, Benjamin D. McNeil, Xinzhong Dong, Joseph D. Hernandez, Ronit Sagi-Eisenberg, Ilan Hammel, Axel Roers, Salvatore Valitutti, Mindy Tsai, Eric Espinosa, Stephen J. Galli
Journal: Journal of Clinical Investigation (2016)

Mast cells (MCs) influence intercellular communication during inflammation by secreting cytoplasmic granules that contain diverse mediators. Here, we have demonstrated that MCs decode different activation stimuli into spatially and temporally distinct patterns of granule secretion. Certain signals, including substance P, the complement anaphylatoxins C3a and C5a, and endothelin 1, induced human MCs rapidly to secrete small and relatively spherical granule structures, a pattern consistent with the secretion of individual granules. Conversely, activating MCs with anti-IgE increased the time partition between signaling and secretion, which was associated with a period of sustained elevation of intracellular calcium and formation of larger and more heterogeneously shaped granule structures that underwent prolonged exteriorization. Pharmacological inhibition of IKK-β during IgE-dependent stimulation strongly reduced the time partition between signaling and secretion, inhibited SNAP23/STX4 complex formation, and switched the degranulation pattern into one that resembled degranulation induced by substance P. IgE-dependent and substance P-dependent activation in vivo also induced different patterns of mouse MC degranulation that were associated with distinct local and systemic pathophysiological responses. These findings show that cytoplasmic granule secretion from MCs that occurs in response to different activating stimuli can exhibit distinct dynamics and features that are associated with distinct patterns of MC-dependent inflammation.
Dose-escalation phase I study of NKTR-105, a novel pegylated form of docetaxel.
Authors: E. Calvo, U. Hoch, D. J. Maslyar, A. W. Tolcher
Journal: Journal of Clinical Oncology (2010)

TPS160 Background: Docetaxel (D) is widely used in the treatment of several solid tumor malignancies. It has a relatively short half-life of 11 hours. NKTR-105 was engineered to provide a sustained release of D to improve its efficacy, safety, and tolerability profile over marketed D. Pharmacokinetic (PK) studies in rats and dogs showed that NKTR-105 improved the D PK profile by reducing its peak concentrations and prolonging its half- life. NKTR-105 demonstrated superior activity over D in mouse models of human lung, colon, and prostate carcinomas. In PK-PD studies, NKTR-105 resulted in sustained D concentrations in plasma and tumor. Equitoxic doses of D and NKTR-105 achieved similar plasma D AUC, but tumor AUC was 2-fold greater after NKTR-105 administration, indicating that the superior antitumor activity of NKTR-105 was mediated by greater and sustained tumor D exposure. The encouraging antitumor activity and unique PK profile formed the basis for the design and initiation of study 08-PDX-01, a phase I, multicenter, open-label, dose-escalation study to assess the safety, tolerability, and pharmacokinetics of NKTR-105 when given on a Q21 day schedule. Methods: The primary objective of this first Phase 1 study is to characterize the safety profile of NKTR-105 and establish a maximum tolerated dose (MTD) of NKTR-105 when given on an every 21-day treatment schedule as 1-hr intravenous infusion. Secondary objectives include determination of the plasma PK profile of NKTR-105 and its metabolite docetaxel and exploratory evaluation of antitumor activity. Patients who are ≥ 18 years old and who have a histologically confirmed, evaluable, or measurable solid tumor that is metastatic or unresectable, for which standard curative or palliative therapies do not exist are eligible. Each cohort of 3 to 6 patients is treated at a single dose level of NKTR-105. Doses are escalated in 25% to 100% increments based on adverse and serious adverse events, dose limiting toxicities, laboratory and PK data. Once the MTD has been identified, a total of up to 20 patients may be treated at that dose to further evaluate the safety, anti-tumor effect and PK of NKTR-105. To date, 17 patients have been enrolled in the study. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Nektar Therapeutics
Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex
Authors: Miao He, Jason Tucciarone, SooHyun Lee, Maximiliano José Nigro, Yongsoo Kim, Jesse Maurica Levine, Sean Michael Kelly, Illya Krugikov, Priscilla Wu, Yang Chen, Ling Gong, Yongjie Hou, Pavel Osten, Bernardo Rudy, Z. Josh Huang
Journal: Neuron (2016)
Ductular bilirubinostasis predicts the evolution to acute-on-chronic liver failure in patients suspected with severe alcoholic steatohepatitis
Authors: Len Verbeke, Tania Roskams, Chris Verslype, David Cassiman, Schalk Van der Merwe, Werner Van Steenbergen, Geert Maleux, Alexander Wilmer, Wim Laleman, Frederik Nevens
Journal: Hepatology (2014)
Abstract 4767: DNA sequences differentially associated with Sirt1 and Dnmt3b during melanoma progression
Authors: Fabiana Marcelino Meliso, Camila Tainah da Silva, Simon Coetzee, Thaís Sarraf Sabedot, Houtan Noushmehr, Regine Schneider-Stock, Miriam Galvonas Jasiulionis
Journal: Cancer Research (2015)

Abstract Melanoma is one of the most worrying tumors due to its high capacity to cause metastasis. Sirt1, a class III histone deacetylase, was shown to be attracted to sites of double strand breaks in DNA, favoring, by recruiting components of the epigenetic machinery, aberrant epigenetic silencing in that region (O’HAGAN et al., 2008). Beyond that, subsequent studies have attributed important roles of Sirt1 and other components of the epigenetic machinery, such as DNA methyltransferases (such as Dnmt3b), in tumor initiation and progression. In this sense, using a murine model of malignant transformation of melanocytes, associated with sustained stress conditions, our goal was to identify genomic sequences differentially associated to Sirt1 and/or Dnmt3B before and after stress condition, represented in our model by anchorage blockade, and analyze if these sequences are targeted by aberrant methylation in cell lines obtained by this process that represent different steps in melanoma progression. We have showed increased DNA damage after 24 hours of anchorage impediment followed by increased Sirt1 expression. In addition, we have showed Sirt1/Dnmt3b association just after this stress condition that leads to malignant transformation. It was identified several DNA sequences differentially associated to Sirt1 and also to Dnmt3b after stress condition which are also associated to genes related to different metabolic processes. Some of these sequences remain associated to Sirt1 and Dnmt3b during melanoma progression, indicating that Dnmt3b remains associated to Sirt1 during malignant transformation. Among the sequences, Tiam1 and Mxd1 are potential targets of Sirt1 and Dnmt3b that have important roles in tumor progression. We have also identified motifs where Sirt1 and Dnmt3b are probably bound before and after stress condition. The main motif related to Sirt1 was coincident with Boris motif. Subsequent analysis are been developed to elucidate the importance of these interesting discoveries. Supported by FAPESP and DAAD. Citation Format: Fabiana Marcelino Meliso, Camila Tainah da Silva, Simon Coetzee, Thaís Sarraf Sabedot, Houtan Noushmehr, Regine Schneider-Stock, Miriam Galvonas Jasiulionis. DNA sequences differentially associated with Sirt1 and Dnmt3b during melanoma progression. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4767. doi:10.1158/1538-7445.AM2015-4767
A panel of patient derived xenograft models gastrointestinal stromal tumours (GIST) for in vivo preclinical drug testing
Authors: Agnieszka Wozniak, Thomas Van Looy, Beppe Floris, Yemarshet Kelemework Gebreyohannes, Jasmien Wellens, Haifu Li, Jasmien Cornillie, Ulla Vanleeuw, Daphne Hompes, Marguerite Stas, Maria Debiec-Rychter, Raf Sciot, Patrick Schöffski
Journal: Annals of Oncology (2014)
Cognitive rest following concussions: rethinking ‘cognitive rest’
Authors: Mark E Halstead, Brenda Eagan Brown, Karen McAvoy
Journal: British Journal of Sports Medicine (2016)

The concepts of physical and cognitive rest are described as the ‘cornerstones’ of concussion management.1 Over the past several decades, we have seen significant swings in the extremes of these concepts. With physical rest, we have seen approaches from allowing a return to full participation within 15 min after clearing of symptoms to restricting all physical activity until the athlete is without any symptoms. Recently, work by Leddy et al 2 encourages more active rehabilitation as tolerated by the athlete promoting exercise before symptoms have completely resolved. Although Leddy's work most likely has not been adopted by most primary care physicians, and possibly some sports medicine physicians, as of yet, clearly we are seeing concussion management take on a more moderate, and likely a more common sense approach, rather than at an extreme.

So what about cognitive rest? Unfortunately for many, cognitive rest is often telling an adolescent after a concussion that they should avoid text messaging, watching television, playing video games and staying out of school until symptoms improve. Yet, despite these recommendations and many individuals preaching …
Une étude prospective multicentrique évaluant l’utilisation en temps réel du narrow-band imagingpour le diagnostic des lésions précancéreuses de l’estomac
Authors: G. Rahmi
Journal: Endoscopy (2016)

De plus en plus de données sont disponibles dans la littérature concernant la détection endoscopique des lésions précancéreuses gastriques. Le narrow-band imaging (NBI) semble améliorer cette détection. Cependant, les résultats actuels sont hétérogènes et peu reproductibles.
P2-323: Outcome of patients with stage III and IV non-small cell lung cancer in Marmara University Hospital, Istanbul, Turkey
Authors: Perran F. Yumuk, Mehmet Teomete, Faysal Dane, Devrim Cabuk, Hale B. Caglar, Ufuk Abacioglu, Gul Basaran, Nazim S. Turhal
Journal: Journal of Thoracic Oncology (2007)
P2-268: Retrospective analysis of diffuse pulmonary infiltrations developed during or after chemotherapy in patients with lung cancer
Authors: Y.K. Kim, S.C. Kim, S.J. Kim, Y.H. Ko, J.H. Kang, H.J. Park, I.R. Yoo, Y.S. Kim, K.Y. Lee, Y.P. Wang, S.H. Park
Journal: Journal of Thoracic Oncology (2007)
Patterns From the Past—Laurel Wreaths and Comb-overs
Authors: Shahjahan Shareef, Eric Laurent Maranda, Faizah Shareef, Aleksandra Augustynowicz, Emily Tongdee, Joaquin J. Jimenez
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
CHEMOTHERAPY (CT) PLUS CETUXIMAB AS 1ST-LINE TREATMENT FOR ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC): META-ANALYSIS OF INDIVIDUAL PATIENT DATA
Authors: N Thatcher, J Pujol, T. J. Lynch, R Rosell, C. A Butts, F. A Shepherd, Johan Vansteenkiste, B De Blas, J Groos, R Pirker
Journal: Annals of Oncology (2010)
Rachel Eileen Wellesley Sillett
Authors: Andrew Sillett, Hugo Sillett, Stephen Spencer
Journal: BMJ (2016)

After qualifying Rachel Eileen Wellesley Sillett (nee Spencer) spent a brief spell in general practice, assisting her older sister in the running of her recently deceased father’s practice in Warwickshire. Thereafter she was in war service with the Royal Army Medical Corps from 1942 to 1945. At the end of the war she was posted to Vienna and joined the United Nations Relief and Rehabilitation Association as a medical …
Defining the Need for Skin Cancer Prevention Education in Uninsured, Minority, and Immigrant Communities
Authors: Audrey A. Jacobsen, Ana Galvan, Claudina Canaan Lachapelle, Cheryl B. Wohl, Robert S. Kirsner, John Strasswimmer
Journal: JAMA Dermatology (2016)

As the minority population increases in the United States, the incidence of skin cancer has important public health consequences, including poor skin cancer outcomes, in part because of late-stage diagnosis. Therefore, it is important to identify obstacles in skin cancer prevention in these communities.To characterize skin cancer prevention and education needs in uninsured, minority, and immigrant communities in South Florida.At a large free medical clinic in Florida, a convenience sample of people completed a 23-question survey in English, Spanish, or Haitian Creole assessing their skin cancer risk perception, knowledge, sun protective behaviors and barriers, and desirable outreach methods. All participants were uninsured and living at least 200% below the federal poverty level. Participants were adults recruited from the general waiting room who understood 1 of the 3 languages and were not present for a scheduled dermatology visit.The survey used Likert-type scales, true or false, and yes or no questions. Data were analyzed with SPSS IBM statistical software (version 22) using 1-way analysis of variance, χ2 tests, and Pearson correlations.Among the 219 people invited, 206 participants (mean [SD] age, 43 [13.2] years) completed the survey; 75% of respondents were women who usually worked indoors. Almost a quarter (49 [24.5%) had never heard of skin cancer or melanoma. Nearly half (89 [44.3%]) had never conducted a self-skin examination. One in 5 (41 [20.7%]) believed that people with dark skin cannot get skin cancer. Three quarters (156 [75.7%]) of respondents fell into the "low/inconsistent" sun protective behavior category. Barriers to sun-protective behaviors were "using sun protection is too hot" (75 participants [39.3%]) and "I forget." (72 [37.7%]). More than 85% (175 [87.9%]) wanted to learn more about how to prevent skin cancer. Watching a video (37.3%) and text messaging (30.8%) were identified as the most popular outreach methods.Important barriers to skin cancer prevention were lack of knowledge, the belief that dark skin was protective, and using sun protection made them feel too hot. Skin cancer education and intervention efforts in uninsured, minority, immigrant populations may be provided by videos and text messaging.
Effects of exposure to bisphenol A and ethinyl estradiol on the gut microbiota of parents and their offspring in a rodent model
Authors: Angela B. Javurek, William G. Spollen, Sarah A. Johnson, Nathan J. Bivens, Karen H. Bromert, Scott A. Givan, Cheryl S. Rosenfeld
Journal: Gut Microbes (2016)

Gut dysbiosis may result in various diseases, such as metabolic and neurobehavioral disorders. Exposure to endocrine disrupting chemicals (EDCs), including bisphenol A (BPA) and ethinyl estradiol (EE), especially during development, may also increase the risk for such disorders. An unexplored possibility is that EDC-exposure might alter the gut microbial composition. Gut flora and their products may thus be mediating factors for the disease-causing effects of these chemicals. To examine the effects of EDCs on the gut microbiome, female and male monogamous and biparental California mice (Peromyscus californicus) were exposed to BPA (50 mg/kg feed weight) or EE (0.1 ppb) or control diet from periconception through weaning. 16s rRNA sequencing was performed on bacterial DNA isolated from fecal samples, and analyses performed for P0 and F1 males and females. Both BPA and EE induced generational and sex-dependent gut microbiome changes. Many of the bacteria, e.g. Bacteroides, Mollicutes, Prevotellaceae, Erysipelotrichaceae, Akkermansia, Methanobrevibacter, Sutterella, whose proportions increase with exposure to BPA or EE in the P0 or F1 generation are associated with different disorders, such as inflammatory bowel disease (IBD), metabolic disorders, and colorectal cancer. However, the proportion of the beneficial bacterium, Bifidobacterium, was also elevated in fecal samples of BPA- and EE-exposed F1 females. Intestinal flora alterations were also linked to changes in various metabolic and other pathways. Thus, BPA and EE exposure may disrupt the normal gut flora, which may in turn result in systemic effects. Probiotic supplementation might be an effective means to mitigate disease-promoting effects of these chemicals.
Haploidentical Allogeneic Hematopoietic Cell Transplantation in Adults with Reduced-Intensity Conditioning and CD3/CD19-Depleted Grafts: Low Toxicity and Fast Engraftment.
Authors: Wolfgang A. Bethge, Christoph Faul, Martin Bornhaeuser, Gernot Stuhler, Peter Lang, Matthias Stelljes, Rupert Handgretinger, Lothar Kanz
Journal: Blood (2006)
P1-116: Pulmonary metastases from a giant tumor cell of bone. A case report
Authors: José F. Corona-Cruz, Luis M. Domínguez-Parra, Edgardo Jimenez-Fuentes, Mario Cuellar-Hübbe, Ana M. Cano-Valdez, Alejandro E. Padilla-Rosciano, Oscar G. Arrieta-Rodriguez, Jaime G. De-La-Garza-Salazar
Journal: Journal of Thoracic Oncology (2007)
Cannabis and Dr Piffard—A Century Ahead of the Curve
Authors: Zachary Theroux, Thomas Cropley
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
P2-055: A serum proteomic analysis of lung squamous cell carcinoma.
Authors: Jeffrey A. Borgia, Casey Frankenberger, Sanjib Basu, Kelly A. Kaiser, Shannon E. McCormack, L.P. Faber, Michael J. Liptay, Philip D. Bonomi, John S. Coon
Journal: Journal of Thoracic Oncology (2007)
<i>BMJ</i>editor asks chief medical officer to set up inquiry into statin risks and benefits
Authors: Nigel Hawkes
Journal: BMJ (2016)

The editor in chief of The BMJ , Fiona Godlee, has called for an independent inquiry into the evidence on the risks and benefits of statins.

In a letter to the chief medical officer for England, Sally Davies, Godlee urged her to intervene in what had become “a bitter and increasingly unproductive dispute.” Though there was good evidence of the benefits of statins to people with cardiovascular disease or otherwise at high risk, the benefits of taking them by people at lower risk was hotly contested, Godlee said, as was the true incidence of side effects such as muscle pain and fatigue.

Her intervention was triggered by the publication in the …