tbuckley/cabot-search huggingface dataset:
Morphologic Variations in an Osteogenic Sarcoma of the Mouse When Transplanted to the Kidney
Authors: Albert W. Hilberg, M.D.
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Morphologic Variations in an Osteogenic Sarcoma of the Mouse When Transplanted to the Kidney Get access Albert W. Hilberg, M.D. Albert W. Hilberg, M.D. National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 4, February 1956, Pages 951–959, https://doi.org/10.1093/jnci/16.4.951 Published: 01 February 1956 Article history Received: 26 August 1955 Published: 01 February 1956
Association of Autoimmune Encephalitis With Combined Immune Checkpoint Inhibitor Treatment for Metastatic Cancer
Authors: Tanya J. Williams, David R. Benavides, Kelly-Ann Patrice, Josep O. Dalmau, Alexandre Leon Ribeiro de Ávila, Dung T. Le, Evan J. Lipson, John C. Probasco, Ellen M. Mowry
Journal: JAMA Neurology (2016)

<h3>Importance</h3> Paraneoplastic encephalitides usually precede a diagnosis of cancer and are often refractory to immunosuppressive therapy. Conversely, autoimmune encephalitides are reversible conditions that can occur in the presence or absence of cancer. <h3>Objective</h3> To report the induction of autoimmune encephalitis in 2 patients after treatment of metastatic cancer with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab. <h3>Design, Setting, and Participants</h3> A retrospective case study was conducted of the clinical and management course of 2 patients with progressive, treatment-refractory metastatic cancer who were treated with a single dose each (concomitantly) of the immune checkpoint inhibitors nivolumab, 1 mg/kg, and ipilimumab, 3 mg/kg. <h3>Exposures</h3> Nivolumab and ipilimumab. <h3>Main Outcomes and Measures</h3> The clinical response to immunosuppressive therapy in suspected autoimmune encephalitis in the setting of immune checkpoint inhibitor use. <h3>Results</h3> Autoantibody testing confirmed identification of anti–<i>N</i>-methyl-D-aspartate receptor antibodies in the cerebrospinal fluid of 1 patient. Withdrawal of immune checkpoint inhibitors and initiation of immunosuppressive therapy, consisting of intravenous methylprednisolone sodium succinate equivalent to 1000 mg of methylprednisolone for 5 days, 0.4 mg/kg/d of intravenous immunoglobulin for 5 days, and 2 doses of rituximab, 1000 mg, in 1 patient and oral prednisone, 60 mg/d, in the other patient, resulted in improved neurologic symptoms. <h3>Conclusions and Relevance</h3> Immune checkpoint inhibition may favor the development of immune responses against neuronal antigens, leading to autoimmune encephalitis. Early recognition and treatment of autoimmune encephalitis in patients receiving immune checkpoint blockade therapy will likely be essential for maximizing clinical recovery and minimizing the effect of drug-related toxic effects. The mechanisms by which immune checkpoint inhibition may contribute to autoimmune encephalitis require further study.
Insulin-Binding Antibodies in Plasma After Administration of Insulin to Rabbits
Authors: J L STRIEBEL, G D MOLNAR, C A OWEN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Agoraphobia without panic: clinical reappraisal of an epidemiologic finding
Authors: E Horwath, J D Lish, J Johnson, C D Hornig, M M Weissman
Journal: American Journal of Psychiatry (1993)

In the United States, the consensus among clinicians and researchers, reflected in DSM-III-R, is that agoraphobia is a conditioned response to panic attacks and almost never occurs without panic attacks. The predominant view in the United Kingdom is that agoraphobia frequently occurs in the absence of panic. While clinicians report that they rarely see patients with agoraphobia who have no history of panic disorder, community studies report that agoraphobia without panic disorder is common. For example, the Epidemiologic Catchment Area (ECA) study found that 68% of 961 persons with agoraphobia had no history of panic attacks or disorder.To understand this discrepancy, 22 subjects who had been diagnosed as having agoraphobia without panic disorder or panic attacks in the ECA study were blindly reinterviewed 7-8 years later with the Schedule for Affective Disorders and Schizophrenia--Lifetime Version Modified for the Study of Anxiety Disorders; data from these interviews were blindly reviewed by a research psychiatrist who was not involved in the original data collection or the reinterview process.On reappraisal, 19 of the 22 subjects had simple phobias or fears but not agoraphobia. One subject had probable agoraphobia without panic attacks, one had definite panic disorder with agoraphobia, and one had probable agoraphobia with limited symptom attacks.Epidemiologic studies that used the Diagnostic Interview Schedule and lay interviewers, such as the ECA study, may have over-estimated the prevalence of agoraphobia without panic. Agoraphobia without panic attacks occurs but is uncommon, and the diagnostic boundary between agoraphobia and simple phobia is unclear.
SP0140 Lumping Syndromes using Splitting Antibodies
Authors: N. De Vries
Journal: Annals of the Rheumatic Diseases (2015)

IgG4 related disease (IgG4-RD) is an infiltrating and tumor-forming, inflammatory disorder. At present many aspects of its etiology and pathogenesis are unclear, although a recent survey implicated organic solvents in its etiology. The disease can affect many organs. This often includes bile ducts and/or pancreas, but may present itself in many other organs, e.g. the urinary tract, retroperitoneum, testes, lymphatic system, lung, joint, aorta, thyroid and salivary glands. Its presentation as a tumor-forming process in different organs may easily lead to misidentification as a malignancy, e.g. a cholangiocarcinoma or a lymphoma. In this context, clinically the diagnosis is important but may be difficult. It is largely based on the pattern of organ involvement, typical histology, findings in imaging, an elevated serum IgG4, and a good response to corticosteroid therapy. However, serum IgG4 may be normal, the clinical presentation atypical and the therapy response poor. Recently, a novel technology, performing IgG4 clonality analysis of B-cell receptor repertoires in peripheral blood samples, was shown to readily and sensitively identify patients with IgG4-RD. First line of treatment is often prednisolone, which is usually very effective in the initial phase. Relapses occur often after tapering, and in many cases low-dose corticosteroids are indicated. In therapy resistant cases anti-CD20 therapy has been used with success. <h3>Disclosure of Interest</h3> None declared
Fluoroless endoscopic ultrasound-guided biliary drainage after failed ERCP with a novel lumen-apposing metal stent mounted on a cautery-tipped delivery system
Authors: Fabia Attili, Mihai Rimbaş, Domenico Galasso, Alberto Larghi
Journal: Endoscopy (2015)

Endoscopic ultrasound (EUS)-guided biliary drainage in patients in whom endoscopic retrograde cholangiopancreatography (ERCP) has failed is rapidly gaining acceptance as a valid alternative to percutaneous drainage [1]. In the last few years, fully covered self-expandable metal stents specifically designed for EUS transmural drainage procedures have become available [2] [3]. Recently, one of these stents has been incorporated into an electrocautery-enhanced delivery system (Hot AXIOS; Boston Scientific, Natick, Massachusetts, USA) [4] [5] ([Fig. 1]), allowing the procedure, from puncturing to delivery of the stent, to be performed in one step.
Fracture of the Month 30 Number
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1962)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SP0125 “Practical Skills Session” Entitled “ABCS of Biopsies: When to Perform and How to Interpret”: Novel Insights in Sjogren's Syndrome Salivary Gland Histopathology
Authors: A.A. Kruize
Journal: Annals of the Rheumatic Diseases (2015)

Main elements of the intended lecture. After history taking and physical examination, additional investigations may be helpful to confirm a tentative diagnosis or to rule out other diagnoses. Additional investigation(s) should meet with the following conditions: it should give additive information to the information already available, it should be discriminative and the outcome should have therapeutic consequences. Participation in studies on clinical or translational scientific issues may also require additional investigations to complete classification and/or inclusion criteria. Salivary gland biopsy may be indicated to confirm a presumptive diagnosis of primary Sjögren9s syndrome (pSS) and other conditions causing dryness and/or salivary gland enlargement including IgG4 related disease and sarcoidosis. Labial salivary gland biopsy, which is to be performed easily by a rheumatologist, is widely considered and used as the single most specific test for confirming a diagnosis of pSS. In clinical practice, the main histo-pathological findings in salivary glands of pSS patients include focal sialo-adenitis and an increase of IgG and IgM containing plasma cells. New techniques are reported to be less invasive, without loss of information. Technical procedures, limitations and complications will be summarized. Despite impressive scientific progress in understanding the roles of T and B cell subsets in ongoing inflammation in salivary tissue in pSS, the natural evolution of this inflammation is largely unknown. For clinical practice, however, novel insights may influence daily clinical practice directly. For instance, in children, modest focal sialadenitis, also with a focusscore &lt;1, is recently reported to be indicative for pSS. In adult pSS patients, the role of ectopic germinal centers, present in 25% of pSS salivary glands, in predicting more sever disease including the development of lymphoma is emphasized. Also, routine salivary gland assessment is reported to be of prognostic value: a focus score ≥3 has a positive predictive value for enhanced systemic disease and the development of lymphoma. Key messages to share How to use labial salivary gland biopsy in diagnosis and classification of pSS. Labial salivary gland biopsy is to be performed easily by a rheumatologist. Routine assessments are of prognostic value. <h3>Disclosure of Interest</h3> None declared
Inflammatory Autobullectomy
Authors: R B Goodman, S Lakshminarayan
Journal: New England Journal of Medicine (1996)

Figure 1. A 43-year-old man with bullous emphysema was admitted to the hospital with pneumonia. On admission a chest film (Panel A) showed a bulla (white arrow in Panels A through G), which had also been present 15 months earlier, adjacent to right-lower-lobe pneumonia (thick black arrow in Panel A and Panel B). After three days of antibiotics, an air-fluid level (thin black arrow in Panel B, Panel C, Panel D, and Panel E) developed within the bulla (Panel B). The clinical symptoms and the right-lower-lobe infiltrate resolved (Panel C) during the ensuing six-week course of amoxicillin at a dose . . .
Renal Cortical Index and Other Roentgenographic Renal Measurements
Authors: P VUORINEN, P ANTTILA, U WEGELIUS, A KAUPPILA, E KOIVISTO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sixty seconds on . . . Government research
Authors: Anne Gulland
Journal: BMJ (2016)

Don’t be such a cynic. A new report by the campaigning organisation Sense about Science has discovered that the government commissions lots of research but results are “held back when the findings are politically awkward.”1

Yes, it sounds odd but it’s important. The former lord justice of appeal, Stephen Sedley, found that evidence on the effects of minimum alcohol pricing, reducing sugar consumption, …
Alpha-Interferon and Oral Fluorouracil in the Treatment of Unremovable and/or Metastatic Renal Cancer
Authors: R. Gutiérrez, P. Carretero, J.A. Romero, R. Alvarez-Vijande, J.M. Gil-Vernet, Jr., R. Samsón, I. Fernândez
Journal: European Urology (1991)
OC-025 The first report of the UK multicentre double balloon enteroscopy registry: broadening the international deep enteroscopy experience: Abstract OC-025
Authors: E J Despott, S Hughes, A Deo, D S Sanders, R Sidhu, R Willert, J Plevris, K Trimble, J Jennings, C Fraser
Journal: Gut (2010)

<h3>Introduction</h3> Double balloon enteroscopy (DBE) has been a pivotal endoscopic technology, transforming the investigation and management of small bowel (SB) disorders by facilitating direct endoscopic access of the entire small bowel. <h3>Methods</h3> We report the initial experience of the UK multicentre registry (six centres) since the introduction of DBE in the UK in 2005. <h3>Results</h3> 550 cases (322 men) were performed. Mean age was 56 years (16–94 years). 189 cases were done under general anaesthesia, 361 cases done under conscious sedation. 372 cases were performed via the oral route, 175 were performed via the rectal route while three cases were performed via an ileostomy. Calculated mean depth of insertion was 270±80 cm and 190±75 cm for oral and rectal routes, respectively. Mean time taken to complete procedures was 74±20 min. Carbon dioxide was used as the insufflating gas in 344 cases while air was used in the remaining 206 cases. DBE was preceded by capsule endoscopy (CE) in 403 cases. Concordance of diagnoses at CE and DBE was 66% and the overall diagnostic yield for DBE was 61%. The indications and therapies applied at DBE are shown (Abstract 025). Significant lesions missed by CE but diagnosed by DBE included large vascular lesions, polyps and other small bowel tumours. Endoscopic therapy at DBE was applied in 38% of procedures. There were three reported complications (2 perforations and 1 acute coronary syndrome); all complications occurred during therapeutic procedures. The overall complication rate for DBE in the series was 0.5%, with a complication rate for therapeutic procedures of 1.4%. There were no cases of acute pancreatitis. Limitations to DBE procedures included patient intolerance, the presence of adhesions and poor bowel preparation. <h3>Conclusion</h3> The initial UK experience is favourable and echoes the results of other national series published to date, showing that DBE is a feasible and safe and endoscopic advancement that enhances the management of small bowel disorders.
Prevalence of rhinoviruses in young children of an unselected birth cohort from the Netherlands
Authors: J.G. Wildenbeest, M.P. van der Schee, S. Hashimoto, K.S.M. Benschop, R.P. Minnaar, A.B. Sprikkelman, E.G. Haarman, W.M.C. van Aalderen, P.J. Sterk, D. Pajkrt, K.C. Wolthers
Journal: Clinical Microbiology and Infection (2016)
Survey of Treatment of 1021 Patients with Myelodysplastic Syndromes in a Tertiary Referal Center 2007-2013
Authors: Jennifer Schemenau, Kathrin Nachtkamp, Blanca Xicoy, Andrea Kuendgen, Corinna Strupp, Thomas Schroeder, Esther Schuler, Guido Kobbe, Norbert Gattermann, Rainer Haas, Ulrich Germing
Journal: Blood (2014)
Exercising in Polluted Areas: Study Suggests Benefits Outweigh the Health Risks of NO <sub>2</sub> Exposure
Authors: Nancy Averett
Journal: Environmental Health Perspectives (2015)

Study Suggests Benefits Outweigh the Health Risks of NO 2 ExposureResearchers have documented adverse effects of exposure to air pollution while exercising, such as reduced lung function among runners after they ran near busy highways 1 and among cyclists after they rode along heavy traffic routes during rush hour. 2 In this issue of EHP, however, investigators report that over the long-term, exposure to air pollution while exercising did not seem to reduce the beneficial health effects of physical activity on mortality risk. 3he authors used data from the Danish Diet, Cancer, and Health study, a prospective investigation of the relationships between diet, lifestyle, and cancer.From 1993 to 1997 the study recruited 57,053 men and women aged 50-65 years living in Aarhus and Copenhagen, the two most polluted cities in Denmark.This analysis included data for 52,061 individuals.At recruitment, participants reported time spent gardening, cycling, walking, and playing sports in the preceding year.The authors identified cancer, cardiovascular, respiratory, and diabetes mortality via a nationwide death registry. 3he investigators estimated air pollution exposures for each participant's home address using mean annual concentrations from 1971 through followup, which ended 31 December 2009.They defined high exposure as the upper 25th percentile of modeled nitrogen dioxide (NO 2 ) concentrations, which were calculated using the Danish AirGIS dispersion modeling system.AirGIS uses data such as traffic counts, meteorology, wind circulation, street configuration, and building position and height. 4The authors adjusted their model to account for a variety of lifestyle factors, such as physical activity at work, smoking status, and marital status. 3 The authors observed a statistically significant inverse association between all the exercise categories, except for walking, and overall mortality, which did not appear to be modified by estimated exposure to NO 2 . 3"Our hypothesis was based on data from the short-term studies showing small damages to the lungs and heart," says lead
Psychiatric participation in the Hootch case: effects on Alaska native education
Authors: J D Bloom, J L Bloom
Journal: American Journal of Psychiatry (1980)

The Hootch case was a class action suit that established the right of Alaska Native students to attend secondary school in their home communities. The authors review the history of Native education, give the background of the suit, and present behavioral science data on school adjustment of Alaska Natives and American Indian students. These data, included in an amicus curiae brief, were incorporated into the court decision. The authors consider this case a positive example of psychiatric involvement in social policy matters.
Reply
Authors: Jeffrey Cui, Rohit Loomba
Journal: Hepatology (2016)

Potential conflict of interest: Nothing to report. Reply: We thank Dr. Manatsathit for his insightful observations regarding the utility of magnetic resonance elastography (MRE) and acoustic radiation force impulse (ARFI) for noninvasively diagnosing fibrosis in nonalcoholic fatty liver disease (NAFLD) patients. MRE has been shown to be highly accurate for diagnosing fibrosis,1 and this study shows that MRE is superior to ARFI for fibrosis diagnosis. We would like to note that NAFLD fibrosis alone, without progression to advanced fibrosis, portends increased mortality and liver transplantation2 and that patients with hepatic steatosis alone may be genetically more susceptible to developing fibrosis.3 Therefore, early, noninvasive fibrosis diagnosis in high‐risk NAFLD patients is critical for the management of NAFLD and its complications, and MRE is more effective than ARFI for this purpose. Future studies are needed to compare MRE against other imaging techniques and clinical prediction rules to devise accurate, cost‐effective diagnostic algorithms to identify NAFLD patients with high risk for disease progression. Additionally, in our study, MRE had significantly better area under the receiver operating characteristic curves than ARFI for diagnosing fibrosis in obese patients (0.850 to 0.729), and this difference remained robust (0.914 to 0.536) in patients with stage 2 obesity (body mass index 35.0‐39.9 kg/m2). Other studies have shown that ultrasound‐based imaging techniques similar to ARFI, including transient elastography, also lose their diagnostic accuracy in higher‐body habitus patients.4 Compared to ARFI, MRE can make detailed fibrosis assessments of a much larger area of the liver and is minimally affected by body habitus.1 Therefore, we believe MRE may be highly useful for diagnosing fibrosis in obese NAFLD patients. Future improvements in MRE, including three‐dimensional MRE, promise even more diagnostic accuracy than traditional MRE.5 We believe MRE offers significant diagnostic advantages over ARFI for diagnosing early stages of fibrosis, especially in obese patients. And given the strong association between NAFLD and obesity, MRE can be a highly valuable tool for fibrosis diagnosis in these patients.
A Case of Nonseminomatous Testicular Tumor with Liver Metastases, Treated by Intrahepatic Arterial Cisplatinum-Diaminedichloride Infusion
Authors: K Kawai, A Sasaki, Y Nishijima, K Kikuchi, M Ohtani, K Rinshou, K Koiso, S Adachi, A Ishikawa, Y Iwasaki
Journal: European Urology (1990)