tbuckley/cabot-search huggingface dataset:
Size Matters in Chest Tubes—Efficacy of Analgesia and Pleurodesis in Patients With Malignant Pleural Effusion
Authors: Salim M. Hayek, Melinda M. Lawrence
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Von Willebrand factor, ADAMTS13, and coronary microvascular obstruction: beautiful hypotheses, ugly facts
Authors: Raffaele De Caterina, Rosalinda Madonna
Journal: Cardiovascular Research (2016)

This editorial refers to ‘The role of ADAMTS13 in acute myocardial infarction: cause or consequence?’ by E.S. Eerenberg et al. , doi:10.1093/cvr/cvw097. 

The great tragedy of Science—the slaying of a beautiful hypothesis by an ugly fact.Thomas Henry Huxley1

ST-segment elevation myocardial infarction (STEMI) usually results from acute thrombotic occlusion of a coronary artery and continues to be, despite preventive and therapeutic advances, a leading cause of death.2 An important therapeutic goal in STEMI is reperfusion of the infarct-related artery, achievable with either fibrinolytic drugs or primary percutaneous coronary intervention (PCI). This in most cases results in the restoration of blood flow to the ischaemic, but still viable, myocardium, reducing infarct size. Accordingly, reducing time to treatment and maximizing myocardial salvage—in keeping with what has been termed the mantra ‘time is muscle’—represent a major challenge in the management of STEMI.3 However, although national and individual hospitals' door-to-balloon times—now taken as a measure of the efficiency of the in-hospital treatment of STEMI—have improved significantly over the past years for patients undergoing primary PCI, in-hospital mortality of STEMI has remained virtually unchanged,4 and the introduction of additional strategies to reduce in-hospital mortality in this population has been advocated. It has been stated that attention has to be turned to the development of systems addressing the continuum of STEMI care, from symptom onset through return to community.5 To this regard, one unmet need is to address the coronary microvascular functional and structural dysfunction and obstruction (CMVO), which occurs frequently even after prompt epicardial recanalization of the infarct-related artery. CMVO has been shown to increase the risk of cardiovascular events regardless of the epicardial disease status.6 …
Reply to: Letter to the Editor on the article “Parathyroid surgery can be safely performed in a community hospital by experienced parathyroid surgeons: A retrospective cohort study”
Authors: Vladimir K Neychev, Maher Ghanem, Stuart L Blackwood, Patricia Aragon Han, Roghayeh Fazeli, Eric Schneider, Alireza Najafian, Dov C Bloch, Michael C Bard, Jay H Klarsfeld, Martha A Zeiger, Richard J Lipton
Journal: International Journal of Surgery (2016)
The clouded crystal ball: a 35-year follow-up of psychiatrists' predictions
Authors: C K Aldrich
Journal: American Journal of Psychiatry (1986)

In 1946-1949 psychiatrists examined in depth more than 200 students from four first-year medical school classes and predicted their future adjustment. Judging by the former students' replies to a questionnaire in 1981-1982, the psychiatrists' favorable predictions were for the most part borne out, whereas the unfavorable predictions were much less likely to have been realized. The psychiatrists appeared to have overemphasized the significance of the psychopathology they discovered and to have underestimated the potential of many of these young adults for spontaneous personality change.
A Study of the Frequency of Achlorhydria Among Japanese in Los Angeles
Authors: Lester Grinspoon, M.D., John E. Dunn, Jr., M.D.
Journal: JNCI Journal of the National Cancer Institute (1959)

A survey of the frequency of achlorhydria was conducted among Japanese in Los Angeles, together with Caucasian and Mexican control subjects. One or more tubeless gastric analyses employing the azure-A exchange resin were performed on 717 Japanese subjects and 318 control subjects of Caucasian and Mexican origin. Of these 1,035 subjects, the data on 26 were excluded from consideration because of a history of previous gastric surgery, and on 46 because of diagnoses of gastric pathology. The Japanese are of especial interest with regard to achlorhydria because of their threefold increased risk to gastric cancer. The frequency of achlorhydria among isei was compared with that among nisei, and no significant difference could be demonstrated. Similarly, the frequency of achlorhydria among all the Japanese as compared to the Caucasian controls indicated there is no difference. However, the data presently available for the Mexican control group indicates that achlorhydria is more frequent in this group than in either the Japanese or Caucasians. Final interpretation of this finding should be reserved until additional data are secured. The reason for the difference in frequencies of achlorhydria in different study groups is discussed as is the reliability of this tubeless gastric analysis. It is felt by the authors that this simple test is quite reliable and that when several results in the same patient differ, this is not due so much to an inherent defect of the test as to the fact that the patient's acid secretory ability changes from time to time.
Attempted Long-Term Culture of Human Bronchial Mucosa and Bronchial Neoplasms&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Relda Cailleau, T. Timothy Crocker, David A. Wood
Journal: JNCI Journal of the National Cancer Institute (1959)

Fragments of adult human bronchial tissue have been maintained in tissue culture for long periods. The epithelial mucosa may retain its ciliary activity for as long as 135 days when grown on perforated cellophane, and not submerged, in a medium composed of 20 percent human placental serum, 40 percent medium 199, and 40 percent Tyrode's solution containing added antibiotics. Some mucus material is retained in the mucous glands for as long as 3 weeks; however, evidence is not available as to whether secretory activity persists. In contrast to the behavior of normal ciliated epithelium, bronchogenic (chiefly squamous-cell) carcinomas have resisted not only propagation but also attempts at long-term survival, by tissue-culture techniques. Histological sections of tissue from bronchogenic carcinoma show entrapped areas of normal ciliated epithelium. Survival and outgrowths of cells from this normal tissue have been noted frequently during unsuccessful attempts to culture neoplastic cells.
Comprehensive Transcriptional Analysis of Early-Stage Urothelial Carcinoma
Authors: Jakob Hedegaard, Philippe Lamy, Iver Nordentoft, Ferran Algaba, Søren Høyer, Benedicte Parm Ulhøi, Søren Vang, Thomas Reinert, Gregers G. Hermann, Karin Mogensen, Mathilde Borg Houlberg Thomsen, Morten Muhlig Nielsen, Mirari Marquez, Ulrika Segersten, Mattias Aine, Mattias Höglund, Karin Birkenkamp-Demtröder, Niels Fristrup, Michael Borre, Arndt Hartmann, Robert Stöhr, Sven Wach, Bastian Keck, Anna Katharina Seitz, Roman Nawroth, Tobias Maurer, Cane Tulic, Tatjana Simic, Kerstin Junker, Marcus Horstmann, Niels Harving, Astrid Christine Petersen, M. Luz Calle, Ewout W. Steyerberg, Willemien Beukers, Kim E.M. van Kessel, Jørgen Bjerggaard Jensen, Jakob Skou Pedersen, Per-Uno Malmström, Núria Malats, Francisco X. Real, Ellen C. Zwarthoff, Torben Falck Ørntoft, Lars Dyrskjøt
Journal: Cancer Cell (2016)
Drugstore cowboys
Authors: Des Spence
Journal: BMJ (2008)

The tears streamed down her face as she clutched her trophy. She was a character actress of impossible quality, completely immersed in her role, living and breathing it. The inflection, pace, timing—utterly believable. She would always hit you when you were at your most vulnerable, arriving unannounced, playing to a full waiting audience for maximum dramatic effect. She would often be supported by an equally talented supporting cast of concerned and utterly insistent “family members.” Such is the exhausting daily matinee performance in which doctors are stung for prescription drugs (diazepam, temazepam, nitrazepam, dihydrocodeine) to be sold on the street outside pharmacies.

Drug seeking behaviour is endemic in health care. Patients systematically and repeatedly lie to get drugs to be sold into the black market. This is a conflict at close quarters, hopelessly manipulative, defying our reason and determination, all but strangled by shape shifting stories. Techniques vary, from expert dramatic performance that presses all the most emotive buttons to evoke sympathy to crude pantomime intimidation (“He’s behind you!”). Other simpler methods are to abuse the repeat prescribing system with frequent requests and to “lose” or alter prescriptions. It is impossible to quantify the scale and scope of diversion of prescription drugs.

Patients target certain practices, certain doctors, and certain times of day but are ever flexible to adapt to new business opportunities. I would like to say that I wasn’t that doctor or that practice—but that too would be a lie.

Is this crime? I suppose it must be. But the doctor-patient relationship is fundamentally one of trust, and we are taught to believe our patients. Confronting patients is almost impossible without any evidence, leaving us largely powerless to police this situation. We either simply accept that many of the drugs we prescribe are sold on or use the time honoured tradition of denying that it happens. But this isn’t a victimless crime, as these drugs are absorbed into a supersaturated drug taking society, precipitating enormous misery. A recent television documentary showed a youth sharing out “blue” diazepam shortly before a descent into mayhem.

What are our options? Certainly, doctors should be educated about cues that indicate when patients are acting and be trained in how to cope with such situations. Closer liaison with local pharmacies might help. But many of us have tried this. Perhaps it is time to consider voluntary bans in certain localities on drugs that are commonly diverted. This drama is real.
March 7, 1924: Discussion on Suppurative Diseases of the Frontal, Ethmoidal and Sphenoidal Sinuses: I.—Illustrative Cases and Specimens: Case of Localized Ethmoidal Suppuration operated upon by the Sluder Method of opening the Ethmoid and Sphenoid intranasally
Authors: W. T. Gardiner
Journal: Journal of the Royal Society of Medicine (1924)
Drug Abuse Among Alcoholic Women
Authors: Marc A. Schuckit, Elizabeth R. Morrissey
Journal: American Journal of Psychiatry (1979)

Of 293 women in an alcoholic treatment center, two-thirds had received prescriptions for drugs of potential abuse, usually hypnotic and antianxiety drugs. One-third of the women admitted abusing substances; 80% of these subjects got prescriptions for potential drugs of abuse while actively abusing. These figures are alarming in light of the lack of evidence that antianxiety drugs, hypnotics, and stimulants are effective in treating alcoholics and drug abusers. Drug-misusing women in this sample reported more suicide attempts and early antisocial problems and had received more psychiatric care than nonabusers. The authors urge that hypnotics, antianxiety drugs, and stimulants almost never be prescribed to outpatient alcoholics and that analgesics be prescribed only with great care.
Leonardo da Vinci as Anatomist (1452-1519)
Authors: E D Gribanov, L Ia Sgibova
Journal: JAMA (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MB-44SUBGROUP-SPECIFIC QUANTITATIVE PROTEOMIC ANALYSIS OF MEDULLOBLASTOMA
Authors: Ling San Lau, Mojca Stampar, Jerome Staal, Huizhen Zhang, Stefan Pfister, Paul Northcott, Michael Taylor, Yetrib Hathout, Javad Nazarian, Kristy Brown, Brian Rood
Journal: Neuro-Oncology (2016)
Medicare Coverage in Nursing Homes — A Broken Promise
Authors: William D. Loeser, Emil S. Dickstein, Leonard D. Schiavone
Journal: New England Journal of Medicine (1981)

Elderly citizens and their concerned offspring incorrectly assume that Medicare coverage surely makes them eligible for care in a nursing home when the need eventually arises. There is a good reason for this assumption — after all, the Medicare pamphlets distributed by the Department of Health and Human Services (HHS; formerly the Department of Health, Education and Welfare, HEW) state that should hospitalization be followed by a need for nursing-home care, Medicare can provide up to 100 days of benefits.1 Although it is clearly stated and generally understood that there are minor impediments to these benefits (e.g., a stay of . . .
Metabolic Characteristics of a Naturally Occurring Preneoplastic Tissue
Authors: L. Kopelovich, S. Abraham, H. McGrath, K. B. DeOme, I. L. Chaikoff
Journal: Cancer Research (1966)

Enzyme activities involved in glucose utilization via the Embden-Meyerhof and the pentose phosphate pathways were compared in subcellular fractions prepared from: ( a ) normal mammary glands excised from virgin, pregnant, lactating, and postlactating C3H mice; ( b ) HAN[4][1] outgrowths from virgin mice; ( c ) spontaneous mammary adenocarcinomas from virgin, pregnant, and lactating mice; and ( d ) mammary adenocarcinomas that arose in HAN outgrowths in virgin mice.

The activities of the following enzymes increased when the normal gland progressed from the pregnant to the lactating state: HK, PGI, AL, α-GPDH, LDH, GPDH, 6-PGDH, RP-GP, and RP. Their activities attained maximum values during lactation and declined when the gland involuted.

No evidence was found that the carcinogenic state involved a change in intracellular location of the enzymes. A large portion of HK activity in the normal lactating gland and in the adenocarcinoma was associated with mitochondria. All other enzymes were found exclusively in cell sap.

Neither normal lactating glands nor adenocarcinomas contained glucokinase (the adaptable enzyme with a high K m for glucose). This was true for both the mitochondrial-bound enzyme and the one located in cell sap.

The HAN outgrowth resembled the normal gland of the pregnant mouse in levels of activities of the following glycolytic enzymes: HK, PGM, PGI, PFK, GPDH, 6-PGDH, and those responsible for ribose-5-phosphate breakdown. In only 3 of its enzymes (AL, α-GPDH, and LDH) did the HAN outgrowth differ from the pregnant mouse mammary gland; the activities of these enzymes were lower in the HAN outgrowth.

The specific activities of enzymes in the mammary adenocarcinomas that arose spontaneously in virgin mice were of the same order as those that developed from HAN outgrowths. In the case of every enzyme except PGM, the specific activities observed in HAN outgrowths excised from virgin mice differed from those of the adenocarcinomas excised from the virgin or pregnant mice.

The specific activities of α-GPDH in adenocarcinomas excised from virgin, pregnant, and lactating mice were much lower than those in normal glands, regardless of the glands' stages of development. The activity of this enzyme in the HAN outgrowth was higher than it was in the tumor, but lower than in normal glands excised from virgin, pregnant, and lactating mice.

Mouse mammary tumors are much less hormone dependent than are normal mammary tissues (11, 25, 28). The findings presented here show, however, that these tumors are not unresponsive to changes in the levels of hormonal activity associated with various physiologic states of the host.

 [1]: #fn-4
MB-96IMPAIRED NEURAL FUNCTION DURING VISUAL-MOTOR PERFORMANCE IN CHILDREN TREATED FOR BRAIN TUMOURS
Authors: Sonya Bells, Colleen Dockstader, Suzanne Laughlin, Eric Bouffet, Jovanka Skocic, Donald Mabbott
Journal: Neuro-Oncology (2016)

MB-96. IMPAIRED NEURAL FUNCTION DURING VISUAL-MOTOR PERFORMANCE IN CHILDREN TREATED FOR BRAIN TUMOURS Sonya Bells1, Colleen Dockstader1, Suzanne Laughlin3, Eric Bouffet2, Jovanka Skocic1, and Donald Mabbott1; The Hospital for Sick Children, Department of Psychology, Toronto, ON, Canada; The Hospital for Sick Children, Department of Haematology/Oncology, Toronto, ON, Canada; The Hospital for Sick Children, Department of Diagnostic Imaging, Toronto, ON, Canada Children treated with cranial radiation therapy for brain tumours exhibit substantial cognitive deficits that may be mediated by impaired neural functioning. We used magnetoencephalography to investigate whether aberrant neural oscillations are present in pediatric brain tumour survivors compared to healthy children during a visual-motor reaction time task. MEG recording (151 channels, VSM MedTech) was acquired for 9 previously irradiated patients and age-matched controls during the visual-motor reaction time task (100 trials in total). Reaction time (RT) was measured along with localized power changes within the visual and motor cortex using beamformer analysis. Patients showed a significantly delayed RT compared to controls (t(2,9) 1⁄4 2.68, p , 0.05). Beamformer analysis revealed that relative to controls, patients had muted event-related desynchrony and synchrony in the beta (13-29 Hz) and alpha (8-12 Hz) bandwidths in motor and visual cortex and potentiated high gamma activity (50-100 Hz) in the contralateral motor cortex. Furthermore, we found differences in peak gamma frequency of the visually-induced oscillations. Peak frequency was measured in the low gamma range (30-50 Hz) in patients and in the high gamma range (50-100 Hz) in controls. Our findings indicate that aberrant neural responses, characterized by reduced alpha and beta power and increased gamma power within the contralateral motor area, and reduced peak gamma in visual areas, underlie impaired visual-motor reaction time in patients. Gamma-band oscillations play an important role in visual processing and are associated with measures of cortical thickness. These oscillatory results may reflect structural differences between these two populations. Neuro-Oncology 18:iii97–iii122, 2016. doi:10.1093/neuonc/now076.92 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Treatment-related toxicity in elderly patients with malignant lymphoma.
Authors: U Tirelli
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.4.679 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3559657 Treatment-related toxicity in elderly patients with malignant lymphoma. U TirellixU TirelliSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.4.679 PDF "Treatment-related toxicity in elderly patients with malignant lymphoma.." Journal of Clinical Oncology, 5(4), pp. 679–680© 1987 by American Society of Clinical Oncology
Functional Relationship between a Dinoflagellate Host and Its Diatom Endosymbiont
Authors: Elisabeth Hehenberger, Fabien Burki, Martin Kolisko, Patrick J. Keeling
Journal: Molecular Biology and Evolution (2016)

While we know much about the evolutionary patterns of endosymbiotic organelle origins, we know less about how the actual process unfolded within each system. This is partly due to the massive changes endosymbiosis appears to trigger, and partly because most organelles evolved in the distant past. The dinotoms are dinoflagellates with diatom endosymbionts, and they represent a relatively recent but nevertheless obligate endosymbiotic association. We have carried out deep sequencing of both the host and endosymbiont transcriptomes from two dinotoms, Durinskia baltica and Glenodinium foliaceum, to examine how the nucleocytosolic compartments have functionally integrated. This analysis showed little or no functional reduction in either the endosymbiont or host, and no evidence for genetic integration. Rather, host and endosymbiont seem to be bound to each other via metabolites, such as photosynthate exported from the endosymbiont to the host as indicated by the presence of plastidic phosphate translocators in the host transcriptome. The host is able to synthesize starch, using plant-specific starch synthases, as a way to store imported photosynthate.
Case report of lateralized affective states immediately after ECT
Authors: P Decina, H A Sackeim, I Prohovnik, S Portnoy, S Malitz
Journal: American Journal of Psychiatry (1985)

Dysphoric states were observed in a patient immediately after right unilateral and bilateral ECT, while euphoric states followed left unilateral ECT, suggesting that disruption of lateralized neural mechanisms may have been involved in the pathophysiology of the affective states.