tbuckley/cabot-search huggingface dataset:
Ethnic density and psychiatric hospitalization: hazards of minority status
Authors: J G Rabkin
Journal: American Journal of Psychiatry (1979)

The relationship between ethnic density (the relative size of a given ethnic group in a multi-ethnic neighborhood) and risk for psychiatric hospitalization was explored for black, white, and Puerto Rican residents of New York City's 338 health areas. The author found that the smaller the ethnic group, the higher its hospitalization rate in comparison to both the rate of other residents in the same area and that of members of the same ethnic group living in areas where they constituted a numerical majority. Analysis of sociodemographic variables showed that the effect of ethnic density on risk for psychiatric hospitalization cannot be accounted for by differences in poverty, family cohesiveness, or population mobility.
Is Esophageal Capsule Endoscopy Feasible? Results of a Pilot
Authors: B Neu, E Wettschureck, T Rösch
Journal: Endoscopy (2003)

Background and Study Aims: Capsule endoscopy (CE) has been shown to be accurate in the evaluation of small-bowel bleeding and possibly also other small-bowel disorders. It is commonly believed that other organs are not suitable for CE. We report here on our experience in studying the distal esophagus using CE under various conditions. Patients and Methods: A prospective evaluation of CE was carried out in three groups: evaluation of the distal esophagus in routine patients (n = 58) mostly examined for suspected small-intestinal bleeding (group 1); in eight patients with signs of grade I - II reflux esophagitis on upper gastrointestinal endoscopy, who were examined in a supine position for esophageal passage (group 2); and in four volunteers who swallowed the capsule attached to a string (group 3). Results: In 62 routine patients initially included in group 1, the median CE exposure time was 2 s (range 0 - 217 s; median of four pictures, range 0 - 434), excluding four patients with extremely delayed esophageal transit (esophageal times: 45 - 226 min); at least one image of the Z line was obtained in 24.1 % of cases, but adequate assessment of 50 % and 100 % of the circumference of the distal esophagus was possible in only 10.4 % and 0 % of these cases, respectively. In group 2, the values were better (adequate visibility rates of 50 % and 100 % in 12.5 % and 37.5 % of the eight patients, respectively), but the correct diagnosis of reflux lesions was obtained in only three of the eight. In group 3, the visibility of the Z line was good, but all four volunteers experienced the procedure with the attached string as being quite unpleasant. Conclusions: Distal esophageal assessment by CE with the aim of providing an easy screening method for reflux lesions is not at present feasible. Technical developments will be necessary to achieve this.
AB0919 The Effect of Proprioception Exercises on Fall Risk Among Osteomalacia Patients
Authors: F. Kahvecioglu, F. Sendur, I. Berkit, K. Bayraktar, C. Yildirim
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In this study we aimed to evaluate the fall risk in patients with osteomalacia and to investigate the effects of proprioception exercises on fall risk <h3>Objectives</h3> Osteomalacia is the softening of the bones which is characterised with increased fall risk. In this study we aimed to evaluate of fall risk among patients with osteomalacia and assess that proprioceptive exercises can decrease this risk. <h3>Methods</h3> Seventy two osteomalacia patients with serum 25(OH)D levels below 20 ng/ml were included in this study. Patients9 age, gender, body mass index, occupational and educational status were recorded. Serum 25(OH)D, PTH and calcium concentrations were analized at the beginning and in the end of the study. Fall risk which was assessed by "Fall Risk Assessment Device" (Tetrax) and "Timed Up and Go" (TUG) tests were administered for each patient. Activity of daily living and quality of life were asessed by using HAQ and SF-36 questionnaire. All subjects were choosen by randomising into two groups as exercise group and group who have sham exercise. Vitamin D supplementation were given both groups as a same dosage. Although only sham exercise were administered to the control group, proprioception exercise protocol were applied to the exercise group. Ten days all patients performed their exercises under supervision of same physiotherapist. After that the exercises has administered as a home exercise program for three months. Patient visits were performed weekly by phone to control the procedure. <h3>Results</h3> At the end of treatment period average of fall risk assessment, TUG time, hip and widespread body pain were found significantly decreased in exercise group. After administration of SF-36 and HAQ to all patients the results shows that proprioception exercises have also significantly beneficial effects on quality of life of osteoamalacia patients <h3>Conclusions</h3> This study us that proprioception exercises provide additional benefit to osteomalacia patients by decreasing fall risk, improving balance and coordination when compared to conventional therapy without exercise. Therefore, proprioception exercises have to recommend to all osteomalacia patients who undergone conventional treatment. <h3>References</h3> Reginato AJ, Coquia JA. Musculoskeletal manifestations of osteomalacia and rickets. Best Pract Res Clin Rheumatol 2003; 17(6): 1063-80. Fraix M. Role of the musculoskeletal system and the prevention of falls. J Am Osteopath Assoc 2012; 112(1): 17-21 Sharma L: Proprioceptive impairment in knee osteoarthritis. Rheum Dis Clin North Am 1999; 25(2): 299-314. <h3>Disclosure of Interest</h3> None declared
Paclitaxel in ovarian cancer: how can we make it better?
Authors: S A Cannistra
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.9.1743 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7916037 Paclitaxel in ovarian cancer: how can we make it better? S A CannistraxS A CannistraSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.9.1743 PDF "Paclitaxel in ovarian cancer: how can we make it better?." Journal of Clinical Oncology, 12(9), pp. 1743–1744© 1994 by American Society of Clinical Oncology
Studies in Sensory Deprivation
Authors: Y Nagatsuka
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0617-HPR What are the Educational Needs of Nurses Involved in the Care of Childen and Young People with Rheumatic Disease?
Authors: N. Smith, H. Foster, R. Wyllie, C. English, B. Davies, T. Rapley
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Recent advances in the management of paediatric and adolescent rheumatology have developed the need for highly specialist nurses within the multidisciplinary team. This has resulted in nurses working in shared care within other health care settings (e.g. community care, primary care, general paediatrics and adult rheumatology) demanding an enhanced knowledge base and new skill set. There is an important role for education and support for not only nurse specialists but also nursing colleagues. <h3>Objectives</h3> This study aims to establish the essential "core" learning needs of nurses delivering care to children and young people with rheumatic disease within a variety of health care settings. <h3>Methods</h3> Multi-method research was conducted using online survey, focus groups and interviews with key nursing stakeholder groups including clinical nurse specialists (CNS, n=28), nursing students (n=15), health visitors (n=3) and nurses from general paediatrics (n=2), community (n=7), research (n=5) and adult rheumatology (n=4). An online survey of CNS within the British Society for Paediatric and Adolescent Rheumatology (BSPAR) (response rate: 77%, with 27/35 respondents) ascertained expert opinion about educational needs based on experience, knowledge and skills, and how these mapped to the needs of different nursing groups. The survey results informed the questions for focus groups and 1-1 interviews, which were recorded and transcribed to further explore the educational needs of nurses working outside of the specialism. Transcripts were analysed qualitatively using thematic analysis. This study had ethical approval with informed consent from all participants. <h3>Results</h3> Four core themes emerged: (1) Need for Increased Awareness about Rheumatic Disease, (2) Impact of Personal Experience and Nursing Role, (3) Need for Increased Knowledge about Rheumatic Disease and Management, and (4) Design Components for an Impactful Learning and Information Resource. The level of knowledge needed was stratified by what would be expected within the different nursing roles. The key topics include understanding of conditions and how they may present, treatment and medications, impact of disease and treatment on the child/young person and family, available support for themselves as health care providers, and access to resources to support patients and families, along with contemporary information and research to enable them to be well informed. <h3>Conclusions</h3> This study has identified "core" learning needs for all nursing groups. These learning needs appear dependent on past experience and what would be expected within the spectrum of nursing roles, and the level of knowledge required ranged from novice to expert. Future work will develop resources to meet these educational requirements. <h3>Disclosure of Interest</h3> None declared
P0224 : Nintedanib prevents the development of hepatocellular carcinoma in a mouse model of fibrosis
Authors: V. Tovar, A. Moeni, S. Torrecilla, M. Higuera, J. Peix, I.M. Quetglas, L. Rodriguez-Carunchio, M. Solé, J.M. Llovet
Journal: Journal of Hepatology (2015)
Abstract 16176: Identification of Cardiovascular Progenitors From Human Embryonic Stem Cells
Authors: Reza Ardehali, Shah Ali, Micha Drukker, Oscar Abilez, Timothy Blauwkamp, Roeland Nusse, Irving Weissman
Journal: Circulation (2011)

Cardiomyocytes derived from human embryonic stem cells (hESCs) are promising candidates to regenerate myocardium as a treatment for heart disease. However, this application is limited because of th...
The treatment of adopted versus neglected delinquent children in the court: a problem of reciprocal attachment?
Authors: D O Lewis, D Balla, M Lewis, R Gore
Journal: American Journal of Psychiatry (1975)

The authors investigated the discrepant treatment by a juvenile court of adopted versus neglected delinquents. Adopted delinquents received harsher dispositions in spite of the fact that neglected delinquents often faced more serious charges. The two groups are compared in terms of family structure and the criminal and psychiartic histories of their parents; none of these seems to account for the adoptees' harsher treatment. The authors hypothesize that an interplay of late adoption intrinsic vulnerabilities in the children, and weakness of parental bonds accounts for the differential outcomes.
SP0224 What is New in SLE and APS?
Authors: A. Rahman
Journal: Annals of the Rheumatic Diseases (2015)

The recent history of systemic lupus erythematosus is marked by the development of promising new agents based on research into the underlying biology of the disease, which have seldom carried their promise into successful clinical trials. However, over the last year there have been encouraging data on two biologics, epratuzumab and atacicept, together withe a potential new indication for rituximab in early treatment of lupus nephritis. These issues will be discussed. Observational studies in large numbers of patients with SLE are also important. The Systemic Lupus International Collaborative Clinics (SLICC) group has published a series of papers based on an inception cohort of 1600 patients followed for up to 12 years. These papers tell us about facets of the natural history of the condition, such as development of nephritis and mood disorders. A multi-national group developed Treatment-to-Target guidelines for SLE. While broad-ranging, many of these targets are likely to be feasible in clinical practice. In contrast to SLE, there are very limited options for treatment of the antiphospholipid syndrome (APS). Anticoagulation with warfarin or heparin remains the only form of therapy with a secure evidence base. However, efforts to develop new treatments are progressing and trials of alternative anticoagulants such as rivaroxaban may be of particular interest. Another challenge in the management of APS lies in the fact that the serological tests used to diagnose it are imperfect and it can be difficult to decide which patients testing positive in the anti-cardiolipin, anti-beta-2-glycoprotein I or lupus anticoagulant assays actually require long-term anticoagulation. A series of authoritative reports on the diagnosis and treatment of APS were published as an outcome of taskforces set up at the 2013 international APS conference in Rio de Janeiro and some of their conclusions will be discussed. The concept of "seronegative" APS, i.e. patients with typical features of APS but who test negative in the standard assays is a controversial one. However, some recent papers suggest that at least a proportion of these patients do have antibodies that can be detected by novel assays. <h3>Disclosure of Interest</h3> None declared
Cerebrospinal-Fluid Dynamics
Authors: R A Castellino, L M Zatz, G L DeNardo
Journal: New England Journal of Medicine (1970)

Background: To date hydrocephalus researchers acknowledge the need for rigorous but utilitarian fluid mechanics understanding and methodologies in studying normal and hydrocephalic intracranial dynamics.Pressure volume models and electric circuit analogs introduced pressure into volume conservation; but control volume analysis enforces independent conditions on pressure and volume.Previously, utilization of clinical measurements has been limited to understanding of the relative amplitude and timing of flow, volume and pressure waveforms; qualitative approaches without a clear framework for meaningful quantitative comparison.Methods: Control volume analysis is presented to introduce the reader to the theoretical background of this foundational fluid mechanics technique for application to general control volumes.This approach is able to directly incorporate the diverse measurements obtained by clinicians to better elucidate intracranial dynamics and progression to disorder. Results:Several examples of meaningful intracranial control volumes and the particular measurement sets needed for the analysis are discussed. Conclusion:Control volume analysis provides a framework to guide the type and location of measurements and also a way to interpret the resulting data within a fundamental fluid physics analysis.
PRIMARY SARCOMA OF THE PROSTATE.
Authors: G ROMEO
Journal: JAMA (1900)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Elevated Von Willebrand Factor Antigen Serum Levels Are Associated With Poor Prognosis In Patients With Symptomatic Waldenstrom’s Macroglobulinemia
Authors: Efstathios Kastritis, Evangelos Terpos, Ioannis Papassotiriou, Evangelos Eleutherakis-Papaiakovou, Nikolaos Kanellias, Michail Mazarakis, Maria Gavriatopoulou, Maria Roussou, Meletios A. Dimopoulos
Journal: Blood (2013)
THU0484 More Pain, Stiffness and Ultrasound Detected Changes in Patients with Erosive than Non-Erosive Hand Osteoarthritis: Table 1
Authors: O. Sleglova, O. Ruzickova, K. Pavelka, L. Senolt
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hand osteoarthritis (HOA) is a common and frequent cause of pain. HOA is a heterogeneous group of disorders with two main subsets including non-erosive disease and erosive, sometimes referred to as inflammatory, HOA. Few studies demonstrated inflammatory ultrasound changes and more severe clinical symptoms in patients with erosive compared with non-erosive disease, however the results are inconclusive. <h3>Objectives</h3> The aim of the study was to compare pain, stiffness, physical impairment and ultrasound features between patients with erosive and non-erosive HOA in a cross-sectional study. <h3>Methods</h3> Consecutive patients with symptomatic HOA fulfilling the American College of Rheumatology (ACR) criteria were included in this study. Joint pain and swelling were assessed. Pain, joint stiffness and disability were assessed by the Australian/Canadian OA hand index (AUSCAN). Radiographs of both hands were examined and erosive disease was defined by at least one erosive interphalangeal joint. Synovial hypertrophy and power Doppler signal (PDS) were scored with ultrasound. Synovitis was graded on a scale of 0–3 and osteophytes were defined as cortical protrusions seen in two planes. <h3>Results</h3> Altogether, 134 patients (13 male) with symptomatic nodal HOA were included in this study between April 2012 and January 2015. Out of these patients, 72 had erosive disease.Patient9s characteristics are given in table. The disease duration (p&lt;0.01), duration of morning stiffness (p&lt;0.01) and number of clinically swollen joints (p&lt;0.05) were significantly higher in patients with erosive compared with non-erosive disease. According to the AUSCAN, patients with erosive compared with non-erosive disease had more pain (p&lt;0.05) and stiffness (p&lt;0.01). US-detected pathologies such as gray-scale synovitis total score (p&lt;0.001), intensity of PDS (p&lt;0.01) and number of osteophytes (p&lt;0.01) were significantly higher in patients with erosive compared with non-erosive disease (table). <h3>Conclusions</h3> In general, this study shows that patients with erosive HOA have more severe pain and stiffness associated with US-detected synovial hypertrophy, inflammatory signs and osteophyte formation than patients with non-erosive disease. <h3>Acknowledgements</h3> This work was supported by the project (Ministry of Health, Czech Republic) for consensual development of research organization 023728. <h3>Disclosure of Interest</h3> None declared
AB0537 Histopathology of Antiphospholipid Nephropathy in Saudis: Table 1
Authors: A. Alarfaj, F. Naseeb, H. Kfoury
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Antiphospholipid syndrome (APS) is characterized by recurrent arterial, venous thrombosis and/or pregnancy losses, in the presence of persistently elevated levels of Antiphospholipid antibodies (APLA). (1)Antiphospholipid nephropathy (APSN) is a renal disease caused by antiphospholipid antibodies (APLA). Two types of APS nephropathy lesions were described previously: Acute lesions described as Thrombotic microangiopathy (TMA) and chronic lesions like Fibrous intimal hyperplasia (FIH), tubular atrophy and Focal cortical atrophy (FCA) (2,3). <h3>Objectives</h3> Describe renal histological features of patients with APS antibodies in SLE patients. <h3>Methods</h3> Over a one-year period, we prospectively recruited 77 consecutive SLE patients admitted for renal biopsy for evaluation of altered renal function. Patients were divided in two groups based on APS antibodies positivity. <h3>Results</h3> Seventy-seven renal biopsies were studied. Thirty APS positive patients [25 (83.3%) females and 5 (16.7%) male], and forty-seven APS negative patients [42 (89.4%) females and 5 (10.6%) males.]. Renal histological features suggestive of APSN were seen in 12/30 (40%) of APS positive patients compared to 4/47 (8.5%) APS negative patients (<i>p&lt;0.00</i>1). APSN Acute lesions [thrombotic microangiopathy (TMA) in 2 (6.6%) patients], while chronic lesions of APSN namely, FCA and FIH in were found in 6 (20%) (<i>p</i>=0.142) and 9 (30%) (<i>p</i>=0.009) of APS patients positive and negative respectively. Redundant and wrinkled segments of basal membrane in 12 (40%) and 5 (10.6%) (p-value 0.004). Glomerular double wall contour was seen in 17 (56.7%) and in 13 (27.7%) of APS patients positive and negative respectively (<i>p</i>=0.016). <h3>Conclusions</h3> The results of this study showed significant association between the presence of APS antibodies and the development of APS nephropathy.In addition it emphasizes the importance of the more specific albeit less frequent renal lesions in APS nephropathy (thrombotic microangiopathy redundant and wrinkled segments of basal membrane glomerular double wall contour). <h3>References</h3> Dusse LM,Silva FD, Freitas LG, Rios DR, Armond SC, Marcolino MS. Antiphospholipid syndrome: a clinical and laboratorial challenge. Rev Assoc Med Bras. 2014; 2(60): 181-6. Gigante A.Gasperini M.L.Cianci R. Barbano B. Giannakakis K. Di Donato D. et al. Antiphospholipid Antibodies and Renal Involvement. Am J Nephrol 2009; 30(5): 405-412. D Cruz Dp. Renal manifestations of the antiphospholipid syndrome. Lupus 2005; 14(1): 45-8. <h3>Disclosure of Interest</h3> None declared