tbuckley/cabot-search huggingface dataset:
Demographics, response, and overall survival of patients with advanced renal cell cancer to sunitinib in a cohort of minority patient population
Authors: M. Shah, S. Sreenivasappa, R. Kouz, B. Ciobanu, M. Mullane, B. Yim
Journal: Journal of Clinical Oncology (2009)

e16164 Background: Sunitinib is a tyrosine kinase inhibitor active in renal cell cancer (RCC). There is scanty literature of its efficacy in minority population. Methods: 21 patients (pts) with RCC who received sunitinib between February 2006-September 2007 were identified and studied as a retrospective cohort. Clinical and survival data were analyzed using fisher's test, chi square test, Kaplan Meier analyses. Results: Of the 21 patients, 11 (52%) were female and 10 (47%) male, 7 (33.3%) African American, 7 (33.3%) Hispanic, and 5 (23.8%) Caucasian. Median age at diagnosis was 59 years (32–74). 7 (33.3%) had clear cell and 3 (14.3%) sarcomatoid pathology. Mixed, poorly differentiated, papillary and unknown histology were 2 (9.5%) each. 12 (57%) pts had stage 4 disease at diagnosis, stage 3 in 3 (14.3%), stage 2 in 1 (4.8%) and 5 (23%) had missing data. 14(66.7%) pts underwent nephrectomy while 7 (33.3%) did not. 6 (28.6%) pts has good MSKCC risk score, 11 (52.4%) intermediate risk and 3 (14.3%) poor risk. Sunitinib was given at a dose of 50 mg daily for 4 wks followed by 2 wks off. Median duration of treatment was 2.5 months (0–9 mts) and median follow up was 13 mts (1–21 mts). Common grade 3–4 toxicities observed were hand foot syndrome (n = 2), hypertension (n = 2) and thrombocytopenia (n = 1). 4 pts discontinued therapy due to adverse events. 5 (23.8%) has stable disease and 13 (61.9%) had progressive disease. Response to sunitinib was not influenced by sex, race, performance status, MSKCC Score, serum calcium level, LDH and hemoglobin level. Median survival of the group was 4 mts with no difference based on gender (p = 0.8), ethnicity (p = 0.8) or histologic type (p = 0.7). Survival of pts with ECOG performance status (PS) 1 was 8 mts, PS 2 was 4 mts, PS 3 was 2 mts (p = 0.001), MSKCC good risk was 9.4 mts, intermediate score was 9.4 mts and poor risk was 2 mts (p = 0.18). Hemoglobin (p = 0.6), LDH (p = 0.6), calcium (p = 0.2) did not affect the survival. Conclusions: In this minority cohort of pts with RCC treated with sunitinib, response and median survival is much lower than the historical controls. Tolerability and side effect profile are similar to reported literature. Prospective studies are warranted in the treatment of RCC with sunitinib in ethnic minority population. No significant financial relationships to disclose.
In primary prevention, the ACC/AHA risk-based approach predicted ASCVD better than trial-based or hybrid approaches
Authors: Michael Blaha
Journal: Annals of Internal Medicine (2016)

Source Citation Mortensen MB, Afzal S, Nordestgaard BG, Falk E. Primary prevention with statins: ACC/AHA risk-based approach versus trial-based approaches to guide statin therapy. J Am Coll Cardiol. 2015;66:2699-709. 26700832
Alpha 4 beta 1 and alpha 5 beta 1 are differentially expressed during myelopoiesis and mediate the adherence of human CD34+ cells to fibronectin in an activation-dependent way
Authors: JM Kerst, JB Sanders, IC Slaper-Cortenbach, MC Doorakkers, B Hooibrink, RH van Oers, AE von dem Borne, CE van der Schoot
Journal: Blood (1993)
Abstract 126: Chlamydia Pneumoniae Induces Foam Cell Formation Of Macrophages By Activating The TLR4/TRIF/IRF3 Pathway
Authors: Shuang Chen, Rosalinda Sorrentino, Kenichi Shimada, Timothy Crother, Moshe Arditi
Journal: Circulation (2007)

Background: Chlamydia pneumoniae (CP) induces macrophage foam cell formation (FCF), a key event in early atherosclerosis, in the presence of low-density lipoprotein (LDL). Recent studies have indicated the role of Toll-Like Receptors in atherogenesis. Liver X receptors (LXR) are nuclear receptors that play central roles in the transcriptional control of lipid metabolism and determinants of atherosclerosis. Induction of LXR-activated genes has also been shown to influence the pathogen pattern recognition activity of the Toll-like receptors 3 and 4 (TLR3/4). The TLR and the LXR pathways converge on the transcription factor IRF3. Objective: We hypothesized that TLR and the LXR and IRF3 pathways participate in CP infection mediated FCF and acceleration of atherosclerosis, and that the MyD88- independent pathway via TLR4/TRIF and IRF3 play a role in this acceleration. Methods: Peritoneal macrophages were isolated from C57BL/6 wild type (WT) mice, IRF3 −/− mice, TLR4 −/− mice and TRIF −/− mice. Cells were treated with UV killed CP (UVCP, 5x10 5 IFU) with or without ox-LDL (100 μg/ml) in the presence or absence of LXR agonist GW3965 (2nM). LPS (10 ng/ml) and PolyI:C (1μg/ml) were used as positive controls as TLR4 and TLR3 ligands, respectively. FCF was examined by Oil Red O staining. The percentages of foam cells in total macrophages were quantified. Results : FCF was significantly reduced in IRF3−/− cells compared with WT cells stimulated with UVCP plus ox-LDL. Foam cells induced by LPS with ox-LDL were also significantly reduced in IRF3−/− cells compared to WT cells (p&lt;0.05). Furthermore, the synthetic LXR agonist GW3965 significantly diminished CP induced FCF in WT cells. FCF was significantly reduced in TLR4−/− and TRIF−/− macrophages compared to WT cells when stimulated with UVCP with ox-LDL (p&lt;0.05). Conclusion : Chlamydia pneumoniae infection can activate the TLR4/TRIF/IRF3 pathway and does play an important role in CP- mediated foam cell formation in macrophages. Therefore, infections such as the one caused by CP, can trigger the TLR4/TRIF/IRF3 pathway leading to the down regulation of LXRs and shifting of cholesterol transport toward pro-foam cell production and thereby accelerating atherogenesis.. Supported by NIH grants AI 067995 and HL66436 to MA.
Brief Communication: Reversible Loss in Suspension Culture of a Major Cell-Surface Glycoprotein of the TA3-Ha Mouse Tumor23
Authors: Douglas K. Miller, Amiel G. Cooper, Michael C. Brown, Roger W. Jeanloz
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Brief Communication: Reversible Loss in Suspension Culture of a Major Cell-Surface Glycoprotein of the TA3-Ha Mouse Tumor Get access Douglas K. Miller, Douglas K. Miller Search for other works by this author on: Oxford Academic PubMed Google Scholar Amiel G. Cooper, Amiel G. Cooper Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael C. Brown, Michael C. Brown Search for other works by this author on: Oxford Academic PubMed Google Scholar Roger W. Jeanloz Roger W. Jeanloz 7 7Address reprint requests to Dr. Roger W. Jeanloz. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 5, November 1975, Pages 1249–1252, https://doi.org/10.1093/jnci/55.5.1249 Published: 01 November 1975 Article history Received: 02 June 1975 Accepted: 27 June 1975 Published: 01 November 1975
Efficient Heparin Assay for Monitoring Regional Heparinization and Hemodialysis
Authors: John P. Darby, Robert J. Sorensen, Thomas F. O'Brien, Paul E. Teschan
Journal: New England Journal of Medicine (1960)

ACTIVE bleeding, the threat of bleeding or bleeding in the immediate past remains the only definite contraindication to the use of artificial-kidney hemodialysis.1 2 3 Predialysis heparinization of the patient to prevent blood coagulation in the extracorporeal circuit is considered to be largely responsible for exacerbations of such bleeding. Therefore, a technic of "regional heparinization" of the dialyzer circuit was devised by Gordon et al.4 to reduce the threat of hemorrhage. This procedure consisted of the infusion of heparin into the blood leaving the patient and of protamine into the blood re-entering the patient. This permitted adequate anticoagulation of the blood in . . .
Predictions of Postoperative Psychiatric Complications
Authors: Harry S. Abram, Benjamin F. Gill
Journal: New England Journal of Medicine (1961)

IN the preoperative evaluation of patients a psychiatric opinion is sometimes requested to ascertain how the patient will respond psychologically after surgery. In our experience even well qualified psychiatrists may have widely divergent views of what the postoperative course will be in a given case. The present study was undertaken to explore the extent to which psychiatric evaluations may be accurate in predicting the psychologic course after surgery and on what information an accurate prediction depends. This work continues the interest of the Massachusetts General Hospital Psychiatric Service in the psychologic aspects of the surgical patient.1 2 3 4 Review of the Literature . . .
Lin28B/Let-7 Axis Regulates Multiple Myeloma Proliferation By Enhancing c-Myc and Ras Survival Pathways
Authors: Salomon Manier, John T Powers, Antonio Sacco, Michaela R Reagan, Michele Moschetta, Siobhan Glavey, Patricia Maiso, Ilyas Sahin, Yuji Mishima, Yosra Aljaway, Xavier Leleu, Aldo M Roccaro, George Q. Daley, Irene M. Ghobrial
Journal: Blood (2013)
Mental health service changes, organisational factors, and patient suicide in England in 1997–2012: a before-and-after study
Authors: Nav Kapur, Saied Ibrahim, David While, Alison Baird, Cathryn Rodway, Isabelle M Hunt, Kirsten Windfuhr, Adam Moreton, Jenny Shaw, Louis Appleby
Journal: The Lancet Psychiatry (2016)
Improved Clinical Outcome after Widespread Use of Coronary-Artery Stenting in Canada
Authors: James M. Rankin, John J. Spinelli, Ronald G. Carere, Donald R. Ricci, Ian M. Penn, J. David Hilton, Mark A. Henderson, Robert I. Hayden, Christopher E. Buller
Journal: New England Journal of Medicine (1999)

The introduction and refinement of coronary-artery stenting dramatically changed the practice of percutaneous coronary revascularization in the mid-1990s. We analyzed one-year follow-up data for all percutaneous coronary interventions performed in a large, unselected population in Canada to determine whether the use of coronary stenting has been associated with improved outcomes.
Surgical Treatment of Lye Strictures of the Esophagus by Mediastinal Colon Transplant without Resection
Authors: George L. Nardi
Journal: New England Journal of Medicine (1957)

LYE strictures of the esophagus have posed a technical challenge to surgeons for the past half century. The extensive inflammatory involvement of both the length and thickness of this organ in this condition renders excisional surgery difficult and hazardous. Yudin1 and Rienhoff2 have summarized the development of current methods of restoring pharyngogastric or intestinal continuity. Transthoracic esophageal resection with esophagogastrostomy is currently the most generally accepted technic of re-establishing alimentary continuity.3 , 4 To avoid the hazards of esophageal resection and the complications of esophagogastric anastomosis, the ascending colon was utilized in the performance of a pharyngocologastrostomy without resection in 2 patients . . .
Effects of Limiting Medicaid Drug-Reimbursement Benefits on the Use of Psychotropic Agents and Acute Mental Health Services by Patients with Schizophrenia
Authors: Stephen B. Soumerai, Thomas J. McLaughlin, Dennis Ross-Degnan, Christina S. Casteris, Paola Bollini
Journal: New England Journal of Medicine (1994)

We examined the effects of a three-prescription monthly payment limit (cap) on the use of psychotropic drugs and acute mental health care by noninstitutionalized patients with schizophrenia. We hypothesized that reducing access to such drugs would increase the use of emergency mental health services and the rate of partial hospitalizations (full-day or half-day treatment programs) and psychiatric-hospital admissions.
Granulocyte–Macrophage Colony-Stimulating Factor after Initial Chemotherapy for Elderly Patients with Primary Acute Myelogenous Leukemia
Authors: Richard M. Stone, Deborah T. Berg, Stephen L. George, Richard K. Dodge, Paolo Alberto Paciucci, Philip Schulman, Edward J. Lee, Joseph O. Moore, Bayard L. Powell, Charles A. Schiffer
Journal: New England Journal of Medicine (1995)

Elderly patients with primary acute myelogenous leukemia (AML) are less likely to enter remission than younger adults, in part because of a higher mortality rate related to severe myelosuppression. Granulocyte–macrophage colony-stimulating factor (GM-CSF) has been shown to shorten the duration of neutropenia and decrease infectious complications when administered after chemotherapy to patients with lymphomas and solid tumors.
Infarction of the Cardiac Atria
Authors: James Lee Wilson, Kenneth P. Knudson
Journal: New England Journal of Medicine (1954)

THE diagnosis of acute infarction of the atrium of the heart is made very rarely in comparison with the probable frequency of its actual occurrence. This condition is seldom recognized during life. Atrial infarction occurred either as an isolated entity or as a concomitant finding with ventricular infarction in 17 per cent of the 182 cases of proved myocardial infarction reported in 1942 by Cushing et al.1 Bean,2 however, observed infarction of the atrium in only 3 of 300 autopsies involving myocardial infarction, and Wartman and Hellerstein3 recorded a 7 per cent frequency among 132 infarcted hearts; isolated atrial lesions . . .
Case 2-2011
Authors: Robert C. Moellering, Gerald F. Abbott, Mary Jane Ferraro
Journal: New England Journal of Medicine (2011)

A 30-year-old woman was transferred to this hospital because of hypotension and respiratory failure. One month earlier, cultures of an abscess on her leg grew MRSA; antibiotics were prescribed and the abscess resolved. On the day of admission, the patient was found unresponsive at home.
Congenital Laryngeal-Abductor Paralysis Due to Nucleus Ambiguus Dysgenesis in Three Brothers
Authors: Dwight Plott
Journal: New England Journal of Medicine (1964)

CHEVALIER Jackson,1 in 1937, made the following comment: "Untold thousands of infants have asphyxiated because of bilateral abductor paralysis — the cyanosis being attributed to a persistent foramen ovale or failure of respiration to start." Despite this statement relatively few reports of congenital laryngeal-abductor paralysis can be found in the literature, and I have been unable to locate any reference to this occurrence in siblings.The present report concerns 3 brothers with congenital laryngeal-abductor paralysis who were examined at Indiana University Medical Center on August 22, 1963, for mental retardation.Case ReportsCase 1. R.D., first seen at the age . . .
AB0291 Correlation Between Anti-Cyclic Citrullinated Peptide Antibody and Various Background Factors of Patients with Rheumatoid Arthritis
Authors: M. Sato, M. Takemura
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The anti-cyclic citrullinated peptide antibody (ACPA) is an important factor for diagnosis and treatment effect prediction of rheumatoid arthritis (RA). Measurement of hepatitis B (HB) antibody level for determination of previous HB infection is recommended when using anti-rheumatic drugs or biological products because of the possible reactivation of the HB virus. <h3>Objectives</h3> We analyzed whether ACPA level and various background factors of RA patients, including the HB antibody positivity rate, are correlated. <h3>Methods</h3> As of March 2014, we successfully analyzed the ACPA positivity rate and the correlation between HB antibodies (HBs and HBc) and various background factors of RA patients (age, onset time, disease duration, and drugs used) in 613 patients with ongoing RA treatment. <h3>Results</h3> The RA cases consisted of 138 male and 475 female patients (77.5%) aged 23–91 years (mean ± SD, 63.1±13.3 years). The number of patients with RA stage I/II/III/IV was 10/207/228/166, and that with RA class 1/2/3/4 was 9/323/270/11. Among the 613 cases, 398 (64.9%) were positive for ACPA. A sex-related difference was not observed in the ACPA positivity rate. No significant differences according to the season or month of birth of the patients were observed in the ACPA positivity rates. The age at onset was 49.8±13.8 years overall, 46.6±12.5 years in the patients with positive ACPA results, and 55.6±14.3 years in the patients with negative ACPA results, suggesting that the age at onset was significantly younger in the patients with positive ACPA results (p&lt;0.0001). The disease duration was 13.4±9.9, 16.4±9.4, and 7.8±7.2 years, respectively, suggesting that disease duration was also longer in the ACPA positive case. The biological product introduction rate was 84.0% in the positive cases and 50.9% in the negative cases, which was apparently higher in the positive cases (p&lt;0.0001). The HBs antibody positive rates were 17.8% and 10.7% in the patients with positive and negative ACPA results, respectively, indicating a significantly higher rate in the positive cases (p&lt;0.02). The HBc antibody positive rates were 16.8% and 13.5%, respectively. No statistically significant difference but a higher trend was observed (p=0.27). The hepatitis C virus antibody positivity rates were 3.3% and 2.8% in the patients with positive and negative ACPA results, respectively. <h3>Conclusions</h3> There was a tendency for longer disease duration, and stage and class progressions in ACPA positive patients. The number of cases being introduced to biological products also increased. Furthermore, it is also important to pay attention to the possible reactivation of HB when administering a strong immunosuppressive therapy to those with high HBs antibody positivity rates and positive ACPA results. <h3>Disclosure of Interest</h3> None declared
hearing the ocean in an empty shell
Authors: D.A. Frater
Journal: Annals of Internal Medicine (2016)

Ad Libitum5 April 2016hearing the ocean in an empty shellD.A. Frater, MDD.A. Frater, MDFrom Dallas, Texas.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M15-3067 Audio Reading - “hearing the ocean in an empty shell” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "hearing the ocean in an empty shell," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail clarity but must ... Author, Article, and Disclosure InformationAffiliations: From Dallas, Texas.Current Author Address: D.A. Frater, MD; e-mail, [email protected]md. PreviousarticleNextarticle Advertisement Audio Reading - “hearing the ocean in an empty shell” Audio. Michael A. LaCombe, MD, Annals Associate Editor, reads "hearing the ocean in an empty shell," by D.A. Frater. Your browser does not support the audio element. Audio player progress bar Step backward in current audio track Play current audio trackPause current audio track Step forward in current audio track Mute current audio trackUnmute current audio track 00:00/ FiguresReferencesRelatedDetails Metrics 5 April 2016Volume 164, Issue 7Page: 487KeywordsDeafnessFearHearingHeartThorax ePublished: 5 April 2016 Issue Published: 5 April 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
The Efficacy and Cost Effectiveness of Vaccination against Influenza among Elderly Persons Living in the Community
Authors: K.L. Nichol, K.L. Margolis, J. Wuorenma, T. Von Sternberg
Journal: New England Journal of Medicine (1994)

Despite recommendations for annual vaccination against influenza, more than half of elderly Americans do not receive this vaccine. In a serial cohort study, we assessed the efficacy and cost effectiveness of influenza vaccine administered to older persons living in the community.
Needle Biopsy of the Thyroid Gland
Authors: Edward Hamlin, Austin L. Vickery
Journal: New England Journal of Medicine (1956)

ALTHOUGH goiters are usually easily palpable and laboratory tests have become more helpful, the clinical diagnosis of thyroid disease is still often unreliable, and conclusive evidence of the nature of any particular goiter is frequently lacking. Surgery is often advised to settle the problem. The differential diagnosis of chronic thyroiditis, for instance, has always been a particularly fertile field of confusion. Marshall and Meissner1 reported a correct preoperative diagnosis of only 17.5 per cent in 114 cases of Hashimoto's thyroiditis. Lindsay and his associates2 found that only 20 per cent of the preoperative diagnoses of goiters, subsequently found to be . . .
EPID-07GLIOBLASTOMA INVOLVING THE SUBVENTRICULAR ZONE: CORRELATIONS TO PATIENT SURVIVAL AND TUMOR BIOLOGY
Authors: Sharon Berendsen, Laurent Schoysman, Jerome Kroonen, Jeroen Hendrikse, Tatjana Seute, Wim G.M. Spliet, Christophe Poulet, Vincent Bours, Pierre A. Robe
Journal: Neuro-Oncology (2015)

BACKGROUND: Several studies suggest that involvement of the subventricular zone (SVZ) by glioblastoma is a negative prognostic factor associating to poor patient survival. We confirm this relationship and explore the biological significance of this prognostic effect in a series of 647 consecutive glioblastoma patients. METHODS: We performed multivariable Cox regression analysis using a retrospective consecutive cohort of 647 primary GBM patients. SVZ involvement was determined using gadolinium-enhanced T1 pre-operative MRI scans. The prognostic effect was adjusted for age, gender, KPS, surgery type, post-operative treatment and tumor volume. Molecular classification and gene set enrichment analyses were performed using mRNA expression microarrays of a subset of these patients. Oncologically relevant protein expression patterns (CD133, NF-kB, C/EBP-b and STAT) were determined using immunohistochemistry on tissue microarrays containing a large subset of the tumors. RESULTS: Involvement of the SVZ is a significant prognostic factor in glioblastoma, and remains associated to survival after correction for age, gender, KPS, surgery type, post-operative treatment and tumor volume (adjusted HR: 1.58, 95% CI: 1.27-1.95). Gene and protein expression correlations to SVZ status to explore the biological significance of this effect will be presented at the SNO meeting. CONCLUSIONS: Involvement of the SVZ is an independent prognostic factor in glioblastoma. The biological relevance of this effect will be presented.
Replication of Feline C-Type Virus at the Plasma Membrane of Erythrocytes&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Lyndon S. Oshiro, Dee O. N. Taylor, John L. Riggs, Edwin H. Lennette
Journal: JNCI Journal of the National Cancer Institute (1972)

Electron microscopic examination of peripheral blood from a cat with an acute lymphocytic leukemia, a cat with reticulum cell sarcoma, and a cat with an anemia revealed C-type particles budding at the surface of reticulocytes and erythrocytes. The 100-mμ particles were best seen in the interphase layer which had a mixture of red and white cells or in the red cell layer adjacent to the buffy coat layer containing erythrocytes and reticulocytes. The concentration of infected erythrocytes, which varied among the animals, was low and required examination of many cells. A cat with severe anemia of unknown etiology showed more infected erythrocytes than did the cats with acute lymphocytic leukemia or reticulum cell sarcoma.