tbuckley/cabot-search huggingface dataset:
Comments on the Guest Editorial on a Proposed Reclassification of Murine Type-C RNA Viruses
Authors: Ludwik Gross
Journal: JNCI Journal of the National Cancer Institute (1975)

Cancer Institute,! Tadao Aoki stated that 'Systematic studies of both avian and murine type-C RNA viruses were initiated by the discovery of the avian type-C RNA virus, Rous sarcoma virus (RSV), in 1911." 2 Dr. Aoki's editorial deals entirely with his proposed reclassification of the mouse leukemia virus strains and related mouse and rat sarcoma viruses and, in my opinion at least, has no relation to the Rous chicken sarcoma virus.The problem of classification of murine leukemia viruses discussed by Dr. Aoki is based fundamentally on the original isolation of the mouse leukemia virus in 1951 in my laboratory.3,4Frankly, I doubt whether Dr. Aoki would have ever written his editorial, had I not first isolated the mouse leukemia virus.And yet, none of my papers on the mouse leukemia virus was quoted among the Editorial's 49 references.The isolation of the mouse leukemia virus was not based on the transmission of the chicken sarcoma by filtrates.If anything, my work on viral etiology of mouse leukemia was inspired by the earlier transmission of leukemia in chickens by filtrates, reported in 1908 by Ellermann and Bang. 5
Differential Effects of Roentgen Rays on Cell Permeability and on Cell Cleavage. Experiments with Egg Cells of &lt;italic&gt;Arbaciapunctulata&lt;/italic&gt;&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Balduin Lucké, Renato A. Ricca, Abthur K. Parpart
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Differential Effects of Roentgen Rays on Cell Permeability and on Cell Cleavage. Experiments with Egg Cells of Arbaciapunctulata Get access Balduin Lucké, Balduin Lucké Search for other works by this author on: Oxford Academic PubMed Google Scholar Renato A. Ricca, Renato A. Ricca Search for other works by this author on: Oxford Academic PubMed Google Scholar Abthur K. Parpart Abthur K. Parpart Department of Pathology, School of Medicine, University of Pennsylvania, Philadelphia, Pa.; Hartford Hospital, Hartford, Conn.; Laboratory of Biology, Princeton University, Princeton, N. J.; and the Marine Biological Laboratory, Woods Hole, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 5, April 1951, Pages 1007–1023, https://doi.org/10.1093/jnci/11.5.1007 Published: 01 April 1951 Article history Received: 12 January 1951 Published: 01 April 1951
Biologic ERects of Plant Toxins and Aflatoxins in Rats 2 3
Authors: Paul M. Newberne
Journal: JNCI Journal of the National Cancer Institute (1976)

After weaning, groups of rats were fed a semi-purified diet containing fiddlehead greens (the unfurled frond of the ostrich fern Matteuccia struthiopteris), mature bracken fern (Pteridium aquilinum), or cycad meal (Cycas circinalis), or this diet plus aflatoxin B1. The groups fed 1–10% fiddlehead greens for 70–73 weeks developed no tumors. whereas those fed mature bracken fern for 67 weeks developed small-bowel adenocarcinomas (3/17). Those fed 3% cycad meal for 64 weeks developed tumors of the liver (4/18), kidney (2/18), small bowel (1/18), and large bowel (6/18). Those given aflatoxin B1 and observed for 73 weeks developed liver tumors (11/15). Thus this study indicates that fiddlehead greens from M. struthiopteris are not toxic or carcinogenic.
BCR-ABL1+ Leukemic Stem Cells Are Dependent On Selectin-Ligand Interactions For Engraftment In The Bone Marrow Niche
Authors: Daniela S. Krause, Katherine Lazarides, Juliana B. Lewis, Ulrich H. von Andrian, David T. Scadden, Richard A. Van Etten
Journal: Blood (2013)
Multistate Outbreak of Human<i>Salmonella</i>Poona Infections Associated with Pet Turtle Exposure — United States, 2014
Authors: Colin Basler, Lyndsay Bottichio, Jeffrey Higa, Belinda Prado, Michael Wong, Stacey Bosch
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

In May 2014, a cluster of human Salmonella Poona infections was identified through PulseNet, the national molecular subtyping network for foodborne disease surveillance. Historically, this rare serotype has been identified in multiple Salmonella outbreaks associated with pet turtle exposure and has posed a particular risk to small children. Although the sale and distribution of small turtles (those with carapace [upper shell] lengths <4 inches [<10.2 cm]) is prohibited by federal law, they are still available for legal purchase online for "bona-fide" scientific, educational, or exhibition purposes, other than use as pets. In addition, small turtles are still available for illegal purchase through transient street vendors, at flea markets, and at fairs.
ESEN : a comparison of vaccination programmes Part two : pertussis
Authors: D Lévy-Bruhl, R G Pebody, K Osborne, I Veldhuijzen, M Valenciano
Journal: Eurosurveillance (1998)

This article is the second of a series of three, which compare vaccination programmes, immunisation schedules, vaccine coverage, and the epidemiological impact of vaccination for diphtheria, pertussis, measles, mumps, and rubella in eight countries (Denma
How healthy is the world? * Commentary: Gilding the global lily
Authors: B. Lomborg
Journal: BMJ (2002)

The chemokine, CXCL10, chemotactic for NK cells, activated T cells, and dendritic cells is highly expressed during viral infections, including HSV-1. The importance of this chemokine to the control of HSV-1 infection was tested using mice deficient in CXCL10 (CXCL10<sup>−/−</sup>). Following corneal infection, HSV-1 viral titers were elevated in the nervous system of CXCL10<sup>−/−</sup> mice, which correlated with defects in leukocyte recruitment including dendritic cells, NK cells, and HSV-1-specific CD8<sup>+</sup> T cells to the brain stem. In the absence of NK cells and HSV-1-specific CD8<sup>+</sup> T cells in wild-type (WT) or CXCL10<sup>−/−</sup> mice, similar levels of virus were recovered in the nervous system, suggesting these cells are responsible for the observed defects in the control of viral replication in CXCL10<sup>−/−</sup> mice. Leukocyte mobilization was also compared between WT, CXCL10<sup>−/−</sup>, and mice deficient in the only known receptor for CXCL10, CXCR3 (CXCR3 <sup>−/−</sup>). NK cell mobilization was comparably reduced in both CXCL10<sup>−/−</sup> and CXCR3<sup>−/−</sup> mice relative to WT animals. However, the reduction in mobilization of HSV-1-specific CD8<sup>+</sup> T cells in CXCL10<sup>−/−</sup> was not observed in CXCR3<sup>−/−</sup> mice following HSV-1 infection. The defect was not the result of an alternative receptor for CXCL10, as Ag-specific CD8<sup>+</sup> T cell recruitment was not reduced in mice which were deficient in both CXCL10 and CXCR3. Thus, CXCL10 deficiency results in reduced mobilization of HSV-1-specific CD8<sup>+</sup> T cells as a result of dysregulation of CXCR3 signaling.
miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer
Authors: Mei Chee Tai, Taisuke Kajino, Masahiro Nakatochi, Chinatsu Arima, Yukako Shimada, Motoshi Suzuki, Hiroyuki Miyoshi, Yasushi Yatabe, Kiyoshi Yanagisawa, Takashi Takahashi
Journal: Journal of Thoracic Oncology (2016)
HG-117ASSESSING THE RESPONSE OF DIFFUSE INTRINSIC PONTINE GLIOMA TO PANOBINOSTAT USING HYPERPOLARIZED<sup>13</sup>C MAGNETIC RESONANCE METABOLIC IMAGING
Authors: Ilwoo Park, Adam Elkhaled, Xiaodong Yang, Renuka Sriram, Dave Korenchan, John Kurhanewicz, Sarah Nelson, Sabine Mueller
Journal: Neuro-Oncology (2016)
Evaluation of 5-Fluorouracil in the Treatment of Cancer
Authors: Kenneth B. Olson, James R. Greene
Journal: JNCI Journal of the National Cancer Institute (1960)

5-Fluorouracil (5-FU) was used in 60 patients with advanced cancer classified as originating in 21 different sites. One case of Letterer-Siwe disease was treated. In 12 patients with advanced carcinoma, objective regression of tumor growth was noted (19.6%). The longest remissions occurred in cancer of the breast and uterus. Thirty-one patients (50.8%) had some degree of subjective relief. Toxicity was severe in most cases and fatal in 11 (18.0%), though the fatalities occurred usually in markedly debilitated patients with extensive cancer. The antineoplastic effect of this drug is of interest because it will produce remissions after other methods of treatment have failed. Perhaps related drugs will prove less toxic and more effective.
NU-04DEVELOPMENT AFTER PEDIATRIC BRAIN TUMOR - A LONGITUDINAL STUDY
Authors: Ingrid Tonning Olsson, Johan Lundgren, Lars Hjorth, Sean Perrin
Journal: Neuro-Oncology (2016)

Background: Patients treated for Pediatric Brain Tumors (PBTs) often experience a decline/stagnation in their cognitive functioning.Anumber of potential risk factors for cognitive decline have been identified including gender (female), young age-at-diagnosis, higher baseline IQ, hydrocephalus at diagnosis, treatment with Whole Brain Radiation Therapy (WBRT), and larger radiation field and/or dose. The aim of this longitudinal study was to statistically model the rate of cognitive decline in a large population-based sample of PBT survivors and to find risk factors for a faster decline. Methods: Study participants were patients diagnosed with PBTs between 2001-2013 and/or who turned 18 years of age between 2006 and 2013 (n = 151). Measures of verbal ability, perceptual reasoning, general cognitive ability, auditory working memory, cognitive processing speed, visual workingmemory and sustained attention were collected longitudinally. Multilevel Linear Modelling (MLM) was used to evaluate the rate of cognitive decline in the sample and to estimate baseline values (risk factors) influencing the rate of decline. Results: A significant decline was found for most cognitive abilities across all patient categories with only elementary verbal skills either stable or improving. Variables predicting lower cognitive performance at baseline were gender (male), age at diagnosis, supratentorial lateral tumor, larger tumor size, and treatment withWBRTor chemotherapy.Conclusions: Pediatric BT survivors experience a decline in age related cognitive performance, regardless of the treatment received. Young age at PBT diagnosis, male, gender, supratentorial lateral tumors, larger tumors and treatment with WBRT or chemotherapy were all correlated with a lowered baseline performance. (Less)
Esophageal rupture caused by compressed nitrous oxide
Authors: Rafie Yakoob, Nazeeh Al Dweik, Hamid Wani, Muneera Mohannadi, Saad Al Kaabi
Journal: Endoscopy (2015)

Rupture of the esophageal wall is most commonly iatrogenic. Boerhaave's syndrome refers to spontaneous esophageal perforation that occurs because of retching or vomiting. Spontaneous perforation of the esophagus results from a sudden increase in intraesophageal pressure combined with relatively a negative intrathoracic pressure. We report a case of esophageal rupture in a young patient caused by exposure to compressed nitrous oxide.
Incidental Detection of Shoulder Peripheral T-Cell Lymphoma During the Redistribution Phase of 201Tl Myocardial Perfusion Scintigraphy
Authors: Yu-Ren Chen, Te-Chun Hsieh, Kuo-Yang Yen, Chia-Hung Kao
Journal: Clinical Nuclear Medicine (2015)

A 74-year-old woman underwent 201Tl myocardial perfusion scan for cardiac symptoms; increased radiotracer accumulation in the left shoulder was found in the redistribution images only, and the shoulder was normal in the stress images. Suspecting septic arthritis subsequent investigations were performed, and peripheral T-cell lymphoma was diagnosed. Attention should also be paid to extracardiac sites in interpreting redistribution images taken as late as 4 hours apart from stress images because some clinically pertinent ancillary findings may be found in redistribution images only.
Silent diabetic nephropathy
Authors: Samar M. Said, Samih H. Nasr
Journal: Kidney International (2016)

Moderately increased albuminuria is widely accepted as the first clinical sign of diabetic nephropathy. However, previous morphometric studies and the autopsy study by Klessens et al. have clearly demonstrated that by the time moderately increased albuminuria is evident, the kidneys in some diabetic patients have already undergone glomerular and tubulointerstitial damage, which indicates that it is not a sensitive marker for diabetic nephropathy. Hence, there is a need for new biomarkers of early diabetic nephropathy.
PNR-12GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR)
Authors: Sander Lambo, Jens Bunt, Christine Schmidt, Stefan M. Pfister, Linda J. Richards, Lukas Chavez, Andrey Korshunov, Marcel Kool
Journal: Neuro-Oncology (2016)

PNR-12. GENOME-WIDE PROFILING OF EMBRYONAL TUMORS WITH MULTILAYERED ROSETTES (ETMR) Sander Lambo1, Jens Bunt2, Christine Schmidt1, Stefan M. Pfister1, Linda J. Richards2, Lukas Chavez1, Andrey Korshunov3, and Marcel Kool1; Division of Pediatric Neurooncology, DKFZ, Heidelberg, Germany; Cortical Development and Axon Guidance, Queensland Brain Institute, Brisbane, Australia; Clinical Cooperation Unit Neuropathology, DKFZ, Heidelberg, Germany ETMRs are rare pediatric brain tumors with a dismal prognosis and largely unknown mechanisms driving the tumors. Characteristic to ETMR tumors are high expression of LIN28A/B and fusion of a Chr19 microRNA cluster (C19MC) to TTYH1 coupled with amplification of the cluster. Our goal is to understand the mechanisms that play a role in tumorigenesis and possibly identify new treatment strategies. We generated genomic data from 23 ETMRs, including three that lack the C19MC amplification, to understand their genome, transcriptome and epigenome. Whole genome sequencing identified no other recurrent genetic events than the fusion and C19MC amplification, frequentlyaccompanied byother complex rearrangements. Interestingly, gene and miRNA expression profiles of ETMRs w/o C19MC amplification wereverysimilar.Analysisof whole genome bisulfite sequencing data supported this similarity, demonstrating large overlapping regions of strong hypomethylation between tumors. Additionally, we generated genome-wide chromatin maps for the major (ENCODE) histone marks. The resulting enhancer landscape, combined with gene and miRNA expression, revealed high similarity with neural tube cells in the forebrain lineage. miRNA target prediction algorithms predicted that NFI transcription factors, highly downregulated in ETMRs, are targeted by multiple miRNAs in C19MC, suggesting a role for NFI genes in ETMR tumorigenesis. Inhibition of NFI protein function in the mouse brain indeed resulted in formation of ectopic rosette-like structures in the forebrain and an increased size of the ventricular zone, but the mice died before tumors could eventually develop. Together our data provides many novel insights into (epi)genetic aberrations and transcriptional networks driving ETMRs. Neuro-Oncology 18:iii7–iii15, 2016. doi:10.1093/neuonc/now067.10 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Case 18-2016
Authors: Alaka Ray, William R. Masch, Kai Saukkonen, Beth T. Harrison
Journal: New England Journal of Medicine (2016)

A 52-year-old woman presented with a unilateral pleural effusion. Several weeks later, uterine bleeding, pelvic fullness, and bloating developed. Magnetic resonance imaging revealed a large pelvic mass. Diagnostic procedures were performed.
Radiology Aids Diagnosis, Therapy
Authors: S A GLADSTONE
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
HG-58GLIOBLASTOMAS IN PEDIATRIC AND YOUNG ADULTS: COMPREHENSIVE ANALYSIS OF H3F3A MUTATIONS
Authors: Vickky Pandit, Vinayak Kadam, Mamta Gurav, Omshree Shetty, Girish Chinaswamy, Prakash Shetty, Aliasgar Moiyadi, Jayantsastri Goda, Tejpal Gupta, Rakesh Jalali, Sridhar Epari
Journal: Neuro-Oncology (2016)
Liverpool residents vote to stop homeopathy funding by CCG
Authors: Jacqui Wise
Journal: BMJ (2016)

Liverpool Clinical Commissioning Group (CCG) has decided to end funding for homeopathy after months of public consultation. The move follows a legal challenge by the Good Thinking Society, a charity that has campaigned against homeopathy funding on the NHS.

Currently, NHS Liverpool CCG commissions homeopathy services to a maximum contract value of £30 000 a year. From April 2014 to April 2015 this service saw 121 new patients and held 447 follow-up appointments with existing patients. The service is …
Granular Cells in Musculature of the Appendix
Authors: R HAUSMAN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Study of the “Gruskin Serological Test” for the Detection of Cancer; the Precipitation of Blood Proteins by Alcohol&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: N. Holmgren, M. S., R. W. Denton, M. S., M. D., S. A. Levinson, Ph. D., M. D., A. C. Ivy, Ph. D., M. D., L. E. Grubgeld, M. S.
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article A Study of the “Gruskin Serological Test” for the Detection of Cancer; the Precipitation of Blood Proteins by Alcohol Get access N. Holmgren, M. S., N. Holmgren, M. S. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. W. Denton, M. S., M. D., R. W. Denton, M. S., M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar S. A. Levinson, Ph. D., M. D., S. A. Levinson, Ph. D., M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. C. Ivy, Ph. D., M. D., A. C. Ivy, Ph. D., M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar L. E. Grubgeld, M. S. L. E. Grubgeld, M. S. Department of Clinical Science, University of Illinois College of Medicine, Chicago, Ill. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 4, February 1951, Pages 689–704, https://doi.org/10.1093/jnci/11.4.689 Published: 01 February 1951 Article history Received: 11 September 1950 Published: 01 February 1951
Focal F-18 FDG Uptake in a Nontoxic Autonomous Thyroid Nodule
Authors: PARK H. CHAN, LEE J. EUN, KIM K. JAI, JOO J. HEE, JANG S. JI
Journal: Clinical Nuclear Medicine (2002)

CHAN, PARK H. M.D.*; EUN, LEE J. M.D.†; JAI, KIM K. M.D.†; HEE, JOO J. M.D.‡; JI, JANG S. M.S.* Author Information
RO-21A PROSPECTIVE ASSESSMENT OF HRQOL OUTCOMES IN MEDULLOBLASTOMA PATIENTS TREATED WITH PROTON RADIOTHERAPY (PT)
Authors: Torunn I. Yock, Saveli I. Goldberg, Ralph E. Vatner, Dillon E. Gaudet, Sara L. Gallotto, Elizabeth A. Weyman, Shannon M. MacDonald, David H. Ebb, Mary Huang, Allison M. Friedmann, Robin M. Jones, Nancy J. Tarbell, Karen A. Kuhlthau
Journal: Neuro-Oncology (2016)
Abstract P080: Dietary Protein, Especially Meat Protein, is Positively Associated with Bone Stiffness Index in Population Consuming Relatively Low Amounts of Protein
Authors: Sun Min Oh, Il Suh, Seon-Joo Park, Hae-Jeoung Lee, Hyeon Chang Kim, Walter C Willett, Diane Feskanich
Journal: Circulation (2012)

Introduction: Dietary protein has a mixed effect on bone health, and it may differ by amount or source. The majority of epidemiological and clinical studies have demonstrated that dietary protein has a positive association with bone health. However, most studies, so far, have been performed in women and in people with moderate- to high-protein diet. Little is known about relationship between dietary protein and bone health in men and in people who consume relatively low amounts of protein. Hypothesis: Since Korean traditional meals depend heavily on carbohydrate, Korean rural residents consume protein, especially animal protein, at relatively low levels compared with that in the Western diets. Therefore, we assessed whether protein intake is beneficial for the people who consume relatively low amounts of protein. Methods: Participants were recruited for a baseline examination of a community-based cohort study in Kangwha, which consist of ten islands with rural villages and a small town on the west coast of South Korea. Among 3,330 participants recruited for a baseline examination between 2008 and 2010,1,182 men and 1,393 postmenopausal women were eligible for the present analyses. Diet was assessed over a 1-year period using a 103-item semi-quantitative food-frequency questionnaire developed for Korean adults. Bone density, measured at the os calcis with a quantitative ultrasound device, was expressed as the stiffness index (SI). A series of analysis of covariance was performed to calculate the adjusted mean SI across sex-specific tertiles of protein intake and their linear trends using a generalized linear model procedure. Total energy intake, age, weight, current smoking status (men only), current hormone therapy (women only), and moderate to high intensity of exercise were potential confounders. Results: In the present study population, the median daily protein intake was 50.5 g in men and 44.0 g in women. In men, the multivariate-adjusted mean SI showed an increasing trend with a higher total protein intake ( P for trend = 0.041). Among various sources of protein, only meat protein was positively associated with the SI ( P for trend = 0.009). Meanwhile, in postmenopausal women, neither total protein nor any protein subtype showed a significant association with the SI. Conclusions: Our findings suggest that total protein, especially meat protein, contributes bone health in men who consume relatively low amounts of protein. Further research is needed to evaluate long-term effects of protein on bone health in this population.