tbuckley/cabot-search huggingface dataset:
AB1097 The Impact of Systemic Lupus Erythematosus on Work Productivity: Data from Patients from the Province of Cordoba, Argentina
Authors: A. Bertoli, M.J. Lόpez Pérez, P. Alba, A. Albiero, E. Albiero, D. Alessio, A. Albarelos, P. Asbert, P. Astesana, M. Audisio, N. Benzaquén, M.S. Castaños Menescardi, M. Colazo, L. Encinas, M.J. Haye Salinas, C. Maldini, A. Maldoado, M.J. Morales, L. Onetti, V. Saurit, V. Savio, M. Werner, C. Gobbi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Since SLE tends to occur during the productive years of life, the cost of the disease derives not only from direct health expenditures but also from the impact the disease has on work productivity. <h3>Objectives</h3> To describe the impact of SLE on work productivity and to assess the factors influencing this outcome measure. <h3>Methods</h3> We studied 225 patients (1987 ACR criteria), age ≥16 years. Work productivity was assessed with the WPAI:Specific Health Problem for SLE. The WPAI yeilds four scores: % work time missed, % of impairment at work, % of overall work impairment and % of non-work related activity impairment. The relationship between socioeconomic-demographic, self-reported quality of life (as per the Lupus PRO), clinical data [clinical manifestations, diagnostic criteria (1987 ACR criteria), disease activity (SELENA-SLEDAI), damage (SLICC Damage Index), co-morbidities (Charlson Index)] and the four scores of the WPAI was examined with the Man-Whitney U test and Spearman9s Rho test. Variables with p≤0.10 in these analyses were then entered in a multivariable linear regression with each score of the WPAI as the dependent variable. <h3>Results</h3> Patients were predominantly females (89%) and they had a median (IQR) age at diagnosis of 26.0 (16.0) years. Median (IQR) disease duration was 96.0 (144.0) months. Median (IQR) percentage of work time missed was 0.0 (25.0)%, of impairment at work was 10.0 (56.0)%, of overall work impairment 0.0 (56.0)% and of activity impairment 40.0 (60.0)%. Variables significant in both, the univariable and multivariable analyses, are shown in Table below <h3>Conclusions</h3> While work productivity is not largely affected in this sample of patients, non-work related activities seems to have a much greater impact in SLE. Patients with a higher disease activity and number of co-morbidities and a lower self-perceived quality of life are at higher risk for work productivity impairment <h3>Disclosure of Interest</h3> None declared
Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging
Authors: Rabee Cheheltani, Rami M. Ezzibdeh, Peter Chhour, Kumidini Pulaparthi, Johoon Kim, Martina Jurcova, Jessica C. Hsu, Cassidy Blundell, Harold I. Litt, Victor A. Ferrari, Harry R. Allcock, Chandra M. Sehgal, David P. Cormode
Journal: Biomaterials (2016)
PWE-298 Ct usage for the detection of post-operative colorectal complications: impact on radiological and surgical services
Authors: CJ Florance, R Francis, J Kynaston, TA Cook
Journal: Gut (2015)

<h3>Introduction</h3> Detecting surgical complications early is a persistent challenge. The aim of this study was to evaluate the use of abdominal and pelvic computed tomography (CTAP) in postoperative colorectal patients, exploring the impact on subsequent clinical management and on hospital resources. <h3>Method</h3> Data were collected on all patients undergoing elective colorectal surgery within an enhanced recovery programme over a two-year period (January 2011–December 2012). Those patients who had a diagnostic postoperative CTAP during their first admission were identified and their case notes analysed. <h3>Results</h3> Three hundred and fifty patients were identified, of which 166 (47%) had undergone laparoscopic procedures. Thirty-nine patients (11%) had a total of 40 diagnostic postoperative CTAP scans. Of these, 15 (38%) had had laparoscopic operations. Median time to imaging was 8 days post-operation. Anastomotic leak was noted in 5 patients undergoing scans (13%); 2 had percutaneous drainage and 3 were managed conservatively with intravenous antibiotics. Collections were identified in 10 patients (25%) of which 1 patient returned to theatre, 3 had percutanous drainage and 6 were managed conservatively. Bowel obstruction was reported in 3 patients (7%) and paralytic ileus in 14 (37%). One patient had a second scan due to further clinical deterioration which suggested likely ischaemic bowel changes, resulting in a return to theatre. No intra-abdominal complications were reported in seven patients (18%). Three patients returned to theatre without any imaging. <h3>Conclusion</h3> There was a high threshold for imaging colorectal patients in the postoperative period with 11% undergoing scans. There was no difference in the proportion undergoing scans between laparoscopic and open procedures. Septic pathology (leak or collection) was identified in a significant proportion (38%) but only 1.4% (5/350) of the overall number underwent radiological intervention. This study shows that CTAP is useful in detecting postoperative complications but has minimal impact on radiological services. <h3>Disclosure of interest</h3> None Declared.
PWE-419 Value and variability of the hirsch index within the context of gastrointestinal surgery in a single uk deanery
Authors: T Abdelrahman, J Brown, J Wheat, C Thomas, WG Lewis
Journal: Gut (2015)

<h3>Introduction</h3> The Hirsch Index (HI) is often used by academic institutions to assess research impact, and on average across all disciplines a full social science professor will have a HI of 4.9 and a Senior Lecturer 2.2. Nevertheless its validity within the context of Gastrointestinal Surgery (GIS) is unknown and the aim of this study was to calculate HI for a cohort of GIS consultant trainers in a single UK Deanery to assess its relative validity. <h3>Method</h3> Contemporary 75 GIS consultant trainers were identified and individual HIs and Total Publication (TP) counts obtained via the Internet search engines, Scopus and Web of Science (WoS). <h3>Results</h3> Median HI (Scopus) was 5 (0–34) and TP 13 (0–152). Median HI vs. TP by subspecialty were: Hepatobiliary 6.5 vs. 17, Oesophagogastric 6.5 vs. 16, and Colorectal 4 vs. 12 (HI p = 0.792, TP p = 0.903). Both academic and university hospital consultants had higher HIs when compared with peers (11 vs. 4 p = 0.001 and 10 vs. 4 p &lt; 0.001). HI was greater than 4.9 in 52% and 2.2 in 73%. Correlation between HI and TP was strong (rho = 0.929, p &lt; 0.001) with the Intraclass Correlation Coefficient between Scopus and WoS HI also highly significant [ICC 0.969 (95% CI 0.951 to 0.981), p &lt; 0.001] <h3>Conclusion</h3> Almost three quarters (73%) of GIS consultants had HIs equivalent to Senior Lecturer level or above, and the academic targets within the 2013 JCST Certificate of Completion of Training Curriculum appear achievable during training. <h3>Disclosure of interest</h3> None Declared.
N9841: A randomized phase III equivalence trial of irinotecan (CPT-11) versus oxaliplatin/5-fluorouracil (5FU)/leucovorin (FOLFOX4) in patients (pts) with advanced colorectal cancer (CRC) previously treated with 5FU
Authors: H. C. Pitot, K. M. Rowland, D. J. Sargent, P. A. Philip, E. P. Mitchell, R. M. Goldberg, S. R. Alberts
Journal: Journal of Clinical Oncology (2005)

3506 Background: Single agent CPT-11 is indicated as standard treatment (Rx) for pts with CRC who failed prior 5FU based Rx. FOLFOX4 is active as 1st and 2nd line Rx of CRC. The primary goal of this trial was to determine whether overall survival (OS) of pts treated with 2nd line CPT-11 (Arm A) was equivalent to Rx with 2nd line FOLFOX4 (Arm B). Pts were to cross-over to the other Rx after 2nd line failure. Methods: Eligible pts had failed one prior 5FU based Rx, either for metastatic disease or ≤ 6 months of adjuvant 5FU Rx. Initial protocol Rx (doses in mg/m2) for Arm A: CPT-11 350 d1 q3w (300 for ECOG performance status = 2, age ≥ 70, or prior pelvic radiation) and Arm B: OXAL 85 d1 + LV 200/5FU 400 bolus + 600 as a 22 hour infusion d1, 2 q2w. Final analysis was scheduled after 405 deaths to have 82% power to detect non-equivalence at a hazard ratio of 1.25. Results: 491 pts were randomized to Rx between 10/99 to12/03 (245-A, 246-B). 289 pts (59%) failed previous 5FU for metastatic CRC. 82% of pts have died. 220 pts (45%) received protocol mandated 3rd line therapy (A-57%, B-43%). Efficacy results (including OS, time to progression (TTP), and response rate (RR)) and common grade 3+ toxicities on initial Rx are shown in the table below. 16 pts died < 60 days of study entry (A-5%, B-2%, p = 0.12). 2nd line Rx with CPT-11 was associated with more grade ≥ 3 nausea, vomiting, diarrhea, and febrile neutropenia; FOLFOX4 had more neutropenia and parasthesias. Conclusions: In pts failing prior 5FU Rx for CRC, OS is not significantly different based on whether 2nd line Rx begins with either CPT-11 or FOLFOX4 (HR=1.04, 95% CI 0.9–1.3). 2nd line Rx with FOLFOX4 produces a higher RR and a trend toward longer TTP. Both arms had notable OS in pts who had failed 1st line 5FU Rx. Supported by NIH Grant CA25224 and Sanofi-Synthelabo. Efficacy & Toxicity (≥ Grade 3), by Initial Rx Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration AstraZeneca, Genentech, Lilly Oncology, Pfizer, Sanofi Pfizer, Sanofi Pfiizer, Sanofi Sanofi
Problems of Southeast Asian children in a refugee camp
Authors: R K Harding, J G Looney
Journal: American Journal of Psychiatry (1977)

The authors describe the efforts made to meet the mental health needs of Vietnamese children and their families in a large refugee camp. Many of the children received strong emotional support from the multigenerational Vietnamese families, and they adapted well to the new environment. However, children separated from their families demonstrated increased emotional vulnerability, and foster placement of children without families presented a serious problem. The authors suggest that our national commitment to these refugees may have ended when they left the confines of the refugee camp.
The Silent Interval in Gastric Cancer: A Study of the Time Elapsing Before Reassertion of Symptoms in Patients with Microscopic Malignancy in the Proximal Line of Excision and without Lymphnode Metastases&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Friesen, Stanley R.
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article The Silent Interval in Gastric Cancer: A Study of the Time Elapsing Before Reassertion of Symptoms in Patients with Microscopic Malignancy in the Proximal Line of Excision and without Lymphnode Metastases Get access Stanley R. Friesen, M. D. Stanley R. Friesen, M. D. Department of Surgery, University of Minnesota Medical School, Minneapolis3 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 545–563, https://doi.org/10.1093/jnci/10.2.545 Published: 01 October 1949
Interferon‐γ, but Not Interleukin‐4, Suppresses Experimental Polymyositis
Authors: Yoko Yoshihashi‐Nakazato, Kimito Kawahata, Naoki Kimura, Nobuyuki Miyasaka, Hitoshi Kohsaka
Journal: Arthritis & Rheumatology (2016)

C protein-induced myositis (CIM) is a mouse model of polymyositis in which activated antigen-specific CD8+ T cells injure the muscles. Animal models of autoimmunity that have been examined in the past for the effects of the type 1 cytokine interferon-γ (IFNγ) and the type 2 cytokine interleukin-4 (IL-4) are all mediated by pathogenic CD4+ T cells. In those models, the disruption of IFNγ leads to up-regulation of IL-17A, exacerbating the disease with neutrophil infiltration into sites of inflammation. This study was undertaken to investigate the roles of IFNγ and IL-4, as well as IL-17A in the absence of IFNγ, in CD8+ T cell-mediated CIM.IFNγ(-/-) mice, anti-IL-17A antibody-treated IFNγ(-/-) mice, IFNγ(-/-) IL-17A(-/-) mice, IL-4(-/-) mice, and wild-type C57BL/6 mice were immunized with skeletal muscle C protein fragments to induce CIM. Muscle tissue specimens were examined histologically.IFNγ(-/-) mice developed myositis at a higher incidence and with greater severity than wild-type mice. Unlike wild-type mice, IFNγ(-/-) mice had infiltration of neutrophils into the endomysial sites of the affected muscles. IFNγ(-/-) mice treated with anti-IL-17A antibodies and IFNγ(-/-) IL-17A(-/-) mice developed myositis with an incidence and severity comparable to those in IFNγ(-/-) mice and showed neutrophil infiltration similar to that in IFNγ(-/-) mice. IL-4(-/-) mice developed CIM comparable to that in wild-type mice.Our findings indicate that IFNγ, but not IL-4, plays a suppressive role in the development of CIM. Unlike in CD4+ T cell-mediated autoimmune disease models, IFNγ prevents factors other than IL-17A from exacerbating myositis and neutrophil infiltration in CD8+ T cell-mediated CIM.
Airport malaria : four new cases in suburban Paris during summer 1999
Authors: D Lusina, F Legros, V Estève, M Klerlein, T Giacomini
Journal: Eurosurveillance (2000)

During the summer 1999, four clustered cases of airport malaria were observed in France. The cases ’ analysis revealed that airport malaria, which is a rare disease whose diagnosis is difficult, can be observed outside occupations at risk, in people livin
A novel reassortant avian influenza A(H7N9) virus in China – what are the implications for Europe
Authors: A Nicoll, N Danielsson
Journal: Eurosurveillance (2013)

Preview this article: A novel reassortant avian influenza A(H7N9) virus in China – what are the implications for Europe, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/15/art20452-en-1.gif
Patterns of depressive symptoms in expectant and new parents
Authors: V D Raskin, J A Richman, C Gaines
Journal: American Journal of Psychiatry (1990)

Depressive symptoms were assessed in 86 couples during pregnancy and after childbirth. Although 59.3% (N = 51) of the couples contained at least one symptomatic spouse during the transition to parenthood, both spouses were symptomatic in only 11.1% (N = 4) of the affected couples during pregnancy and 12.5% (N = 4) after childbirth.
Brief Communication: Detection of T-Cell Surface Antigens in a Marek's Disease Lymphoblastoid Cell Line
Authors: K. Nazerian, J. M. Sharma
Journal: JNCI Journal of the National Cancer Institute (1975)

Indirect membrane immunofluorescence was applied in the study of a lymphoblastoid cell line derived from Marek's disease lymphoma. The cell line tacked surface immunoglobulins and reacted specifically with antisera prepared against chicken thymus cells. Cells transformed by Marek's disease virus were of thymus origin.
Testis cancer: a model for other solid tumors?
Authors: M S Blumenreich
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.4.709 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2066766 Testis cancer: a model for other solid tumors? M S BlumenreichxM S BlumenreichSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.4.709 PDF "Testis cancer: a model for other solid tumors?." Journal of Clinical Oncology, 9(4), p. 709© 1991 by American Society of Clinical Oncology
FRI0433 Nuclear Receptor NR4A1 as a Checkpoint of Physiological Wound Healing and Fibrosis
Authors: K. Palumbo-Zerr, P. Zerr, A. Distler, R. Mancuso, J. Huang, M. Tomcik, C. Scholtysek, C. Dees, C. Beyer, G. Krönke, O. Distler, G. Schett, J. Distler
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Nuclear receptor 4A1 (NR4A1) is a nuclear receptor without endogenous ligand. NR4A1 has pleiotropic regulatory effects on proliferation, differentiation and apoptosis. Deregulation of NR4A1 has been implication in the pathogenesis of cancer, metabolic, vascular and inflammatory diseases. <h3>Objectives</h3> Here, we aimed to characterize the role of NR4A1 in physiologic and pathologic tissue responses and TGF-β signaling. <h3>Methods</h3> Samples from various fibrotic diseases (SSc, IPF, liver and renal fibrosis, cGvHD) and experimental models of fibrosis were analyzed. The expression and molecular regulation of NR4A1 was analyzed by real-time PCR, Western Blot, immunofluorescence, IHC, siRNA mediated knockdown, CoIP, ChIP and reporter assays. <h3>Results</h3> We characterized NR4A1 as an endogenous inhibitor of TGF-β signaling. Overexpression of NR4A1 in cultured fibroblasts prevented the pro-fibrotic effects of TGF-β, whereas knockdown of NR4A1 enhanced the sensitivity towards TGF-β. Similar results were obtained in vivo and conditional inactivation of Nr4a1 in fibroblasts exacerbated fibrosis in various models of skin and pulmonary fibrosis. NR4A1 regulated the expression of TGF-β target genes by SP1-dependent transrepression. Consistent with its anti-fibrotic effects, the levels of active NR4A1 were decreased in patients with SSc, IPF, liver fibrosis and cGvHD and respective mouse models. Mechanistically, chronic activation of TGF-β signaling in fibrotic diseases inactivates NR4A1 by HDAC-mediated epigenetic silencing and AKT-induced phosphorylation. Phosphorylated and thus inactivated NR4A1 accumulates in fibrotic disorders with decreased ratios of active to inactive NR4A1 in fibrotic diseases as compared to non-wounded tissue samples and to physiologic tissue responses during normal wound healing. Csn-B, a selective pharmacological agonist of NR4A1, prevented the inactivation of NR4A1 in fibrotic conditions. Treatment with Csn-B exerted potent anti-fibrotic effects and abrogated the profibrotic effects of TGF-β on cultured fibroblasts. Moreover, Csn-B ameliorated fibrosis in various models of dermal, pulmonary, renal and hepatic fibrosis in preventive and treatment dosing. <h3>Conclusions</h3> NR4A1 is a key-checkpoint for mesenchymal tissue responses that limits TGF-β during normal wound healing. In fibrosis, however, chronically activated TGF-β signaling inactivates the NR4A1 feedback loop thus promoting persistent TGF-β signaling and chronic tissue remodeling. Small molecule agonists of NR4A1 can restore the regulatory activity of NR4A1, limit TGF-β signaling and inhibit fibrosis. <h3>Disclosure of Interest</h3> None declared
Extending Aromatase-Inhibitor Adjuvant Therapy to 10 Years
Authors: Paul E. Goss, James N. Ingle, Kathleen I. Pritchard, Nicholas J. Robert, Hyman Muss, Julie Gralow, Karen Gelmon, Tim Whelan, Kathrin Strasser-Weippl, Sheldon Rubin, Keren Sturtz, Antonio C. Wolff, Eric Winer, Clifford Hudis, Alison Stopeck, J. Thaddeus Beck, Judith S. Kaur, Kate Whelan, Dongsheng Tu, Wendy R. Parulekar
Journal: New England Journal of Medicine (2016)

Treatment with an aromatase inhibitor for 5 years as up-front monotherapy or after tamoxifen therapy is the treatment of choice for hormone-receptor-positive early breast cancer in postmenopausal women. Extending treatment with an aromatase inhibitor to 10 years may further reduce the risk of breast-cancer recurrence.
SAT0315 Calcium Pyrophosphate Dihydrate Deposition Disease: A Proposal of New Ultrasonographic Criteria for CPP Identification in the Joints
Authors: A. Adinolfi, C.A. Scirè, M.A. Cimmino, A. Delle Sedie, E. Filippucci, A. Iagnocco, L.M. Sconfienza, I. Bertoldi, B.M. Bocci, V. Di Sabatino, V. Picerno, M. Galeazzi, B. Frediani, G. Filippou
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In the last decade, ultrasonography (US) demonstrated to be a useful tool for the diagnosis of calcium pyrophosphate dihydrate deposition disease (CPPD) but the heterogeneity of the criteria used for calcium pyrophosphate crystal (CPP) US detection remains the main limit of this technique regarding reproducibility. <h3>Objectives</h3> The aim of this study was to define, on the basis of a systematic literature review and experts9 opinion, the criteria for US identification of CPP deposits. <h3>Methods</h3> The first step of this study was the systematic literature review, aimed to identify all the studies regarding US and CPPD and to retrieve the definitions used for the description of the CPP deposits. In the second step, a rheumatologist expert in musculoskeletal ultrasound (MSUS) drew up a first group of definitions for US CPPD identification based on the results of the literature research. In the third step, the propositions were evaluated by a task force composed by 7 members: 4 senior rheumatologists experienced in MSUS, 1 senior rheumatologist expert in imaging, 1 radiologist expert in musculoskeletal imaging and 1 junior rheumatologist with 3 years9 experience in MSUS. This step was carried out with the Delphi technique. The consensus was considered obtained for a score greater than or equal to 7. <h3>Results</h3> Based on the results of the systematic review, we created five groups of definitions. The first four groups were based on the structure under examination: fibrocartilage, hyaline cartilage, tendons and synovial fluid. For each group we defined: echogenity, shape, localization and behavior during dynamic scanning of CPP deposits. The fifth group contained the most important recommendations and tricks for a correct identification of deposits as described in the literature and also based on the experience of the panel of experts. Three Delphi rounds were needed in order to reach a consensus on each preposition Final definitions for US identification of CPP deposits are summarized in the Table 1. <h3>Conclusions</h3> This is the first attempt, to our knowledge, carried out by a group of experts in order to define US criteria for CPPD identification. The use of these criteria could improve the reproducibility of US among sonographers and promote a greater diffusion of ultrasound as a diagnostic tool for the diagnosis of CPPD. <h3>Disclosure of Interest</h3> None declared
Myocardial Bridging
Authors: Sebastiaan C.A.M. Bekkers, Tim Leiner
Journal: Circulation (2006)

A 52-year-old man with no history of cardiac disease was admitted to the coronary care unit because of an acute anterior wall myocardial infarction.Coronary angiography revealed single-vessel disease of the left anterior descending artery.An occluding thrombus was found distal from a bridging midsegment (Figure 1A and 1B, arrows and arrowheads, and Movie).TIMI III flow was restored after primary percutaneous intervention.Besides the bridging segment, no additional residual stenosis was found.There was only minimal myocardial damage, and the patient made an uneventful recovery.For follow-up purposes, coronary magnetic resonance angiography was done with mid-diastolic and systolic imaging.The large bridging segment almost "disappears" during systolic imaging (Figure 2A and2B).Despite treatment with aspirin, a ␤-blocker, and a calcium antagonist, he still had short-lasting episodes of chest pain.Because of an excellent prognosis in general and limited symptoms, we preferred to follow this patient conservatively.Myocardial bridging has predominantly been an angiographic diagnosis, but newer noninvasive techniques such as electron-beam computer tomography and magnetic resonance coronary angiography are promising.The clinical relevance, however, still has to be elucidated.