tbuckley/cabot-search huggingface dataset:
Vitamin D deficiency and bone loss post gastrectomy for gastroesophageal malignancy.
Authors: Robert Wilson, Kiran Virik
Journal: Journal of Clinical Oncology (2016)

e15557 Background: Metabolic bone disease is a known but incompletely understood consequence of gastrectomy (G). Post G osteoporosis (OP) is multifactorial. Methods: 30 post G patients (2000-2008) from a single academic centre in Australia were evaluated with regards to bone health post G . Exploratory analysis included: age, gender, pathology, type of surgery, 25 OH-vitamin D, calcium, parathyroid hormone (PTH), bone mineral density (BMD), vertebral XRs and N-telopeptides of type I collagen and other risk factors. Results: Median age of the cohort was 67.5 (range 53-83), 22 (73%) were male. Histology showed 16 (53%) gastric adenocarcinoma, 6 (20%) esophageal adenocarcinoma, 5 (17%) gastric/duodenal lymphoma, 2 (7%) GISTs and 1 other. 12 had a total, 12 partial/distal G and 6 had a subtotal G. 22 (73%) had a Roux-en-Y or BR II and 8 had a BRI/other. Median time from surgery to first BMD was 54.5 months (range 12-360). Of n = 27 evaluable patients, baseline mean values: serum 25-OH vitamin D 40.0 nmol/l (range 11-82), calcium 2.26 (range 2.07-2.52) (N = 2.10-2.60 mmol/l), PTH 7.12 pmol/l (range 2.4-13.1). Post G baseline OP was diagnosed in 19/30 (63%), osteopenia (P) in 9 (30%) and 2 (7%) had normal BMD. 24/27 (89%) patients had Vitamin D levels < 50 nmol/l (mean 35.3) and 26/27 (96%) had vitamin D levels < 75 nmol/l (mean 38.4). Mean levels post vitamin D and calcium supplementation: vitamin D = 81.1nmol/l (range 34-147), PTH = 5.26 pmol/l (range 1.3-10.5). Vitamin D levels improved to > 50 nmol/l in 26/27 (96%) patients and to > 75nmol/l in 13/27 (48%). Post supplementation: 92% of patients with secondary hyperparathyroidism (hPTH) normalized their PTH level, on BMD 4/27 (15%) had OP, 18/27 (67%) had P and 4/27 (15 %) had normal BMD. 15/17 (88%) patients with baseline OP received bisphosphates. Post mean bisphosphonate treatment time of 4.5 years, 3/15 (20%) patients had evidence of OP on BMD. This was associated with a rise in mean BMD. Mean BMD declined in the P patients. Conclusions: Poor bone health and vitamin D deficiency is a clinically significant problem post G. OP, vitamin D deficiency and secondary hPTH are common. Patients should undergo long term nutritional and bone health surveillance as well as their oncological follow up post resection.
Current concepts of severe asthma
Authors: Anuradha Ray, Mahesh Raundhal, Timothy B. Oriss, Prabir Ray, Sally E. Wenzel
Journal: Journal of Clinical Investigation (2016)

The term asthma encompasses a disease spectrum with mild to very severe disease phenotypes whose traditional common characteristic is reversible airflow limitation. Unlike milder disease, severe asthma is poorly controlled by the current standard of care. Ongoing studies using advanced molecular and immunological tools along with improved clinical classification show that severe asthma does not identify a specific patient phenotype, but rather includes patients with constant medical needs, whose pathobiologic and clinical characteristics vary widely. Accordingly, in recent clinical trials, therapies guided by specific patient characteristics have had better outcomes than previous therapies directed to any subject with a diagnosis of severe asthma. However, there are still significant gaps in our understanding of the full scope of this disease that hinder the development of effective treatments for all severe asthmatics. In this Review, we discuss our current state of knowledge regarding severe asthma, highlighting different molecular and immunological pathways that can be targeted for future therapeutic development.
Activation of Wnt/β-Catenin in Ewing Sarcoma Cells Antagonizes EWS/ETS Function and Promotes Phenotypic Transition to More Metastatic Cell States
Authors: Elisabeth A. Pedersen, Rajasree Menon, Kelly M. Bailey, Dafydd G. Thomas, Raelene A. Van Noord, Jenny Tran, Hongwei Wang, Ping Ping Qu, Antje Hoering, Eric R. Fearon, Rashmi Chugh, Elizabeth R. Lawlor
Journal: Cancer Research (2016)

Abstract Ewing sarcomas are characterized by the presence of EWS/ETS fusion genes in the absence of other recurrent genetic alterations and mechanisms of tumor heterogeneity that contribute to disease progression remain unclear. Mutations in the Wnt/β-catenin pathway are rare in Ewing sarcoma but the Wnt pathway modulator LGR5 is often highly expressed, suggesting a potential role for the axis in tumor pathogenesis. We evaluated β-catenin and LGR5 expression in Ewing sarcoma cell lines and tumors and noted marked intra- and inter-tumor heterogeneity. Tumors with evidence of active Wnt/β-catenin signaling were associated with increased incidence of tumor relapse and worse overall survival. Paradoxically, RNA sequencing revealed a marked antagonism of EWS/ETS transcriptional activity in Wnt/β-catenin–activated tumor cells. Consistent with this, Wnt/β-catenin–activated cells displayed a phenotype that was reminiscent of Ewing sarcoma cells with partial EWS/ETS loss of function. Specifically, activation of Wnt/β-catenin induced alterations to the actin cytoskeleton, acquisition of a migratory phenotype, and upregulation of EWS/ETS–repressed genes. Notably, activation of Wnt/β-catenin signaling led to marked induction of tenascin C (TNC), an established promoter of cancer metastasis, and an EWS/ETS–repressed target gene. Loss of TNC function in Ewing sarcoma cells profoundly inhibited their migratory and metastatic potential. Our studies reveal that heterogeneous activation of Wnt/β-catenin signaling in subpopulations of tumor cells contributes to phenotypic heterogeneity and disease progression in Ewing sarcoma. Significantly, this is mediated, at least in part, by inhibition of EWS/ETS fusion protein function that results in derepression of metastasis-associated gene programs. Cancer Res; 76(17); 5040–53. ©2016 AACR.
Screen of Small Molecule ONC201/TIC10 Identifies Single Agent Activity and Combinatorial Efficacy with Bortezomib, Rituximab or Dexamethasone in Killing of Acute Lymphoblastic Leukemia Cells
Authors: Jessica M Wagner, Varun Vijay Prabhu, Leah L. Kline, Amriti R. Lulla, Liz J. Hernandez-Borrero, Jeffrey J. Pu, David T. Dicker, Brian M Barth, David F. Claxton, Joshua E. Allen, Wafik S. El-Deiry
Journal: Blood (2014)
Case 35-1967
Authors: C. Miller Fisher, Edward P. Richardson
Journal: New England Journal of Medicine (1967)

Presentation of CaseA forty-eight-year-old man was admitted to the hospital because of the sudden onset of a headache and vertigo.He had been generally well until four years previously, when he began to experience severe bifrontal headaches, which were usually present in the morning, increasing in severity during the day, and were associated with blurring of vision. His physician informed him that his blood pressure was high and prescribed a medication of unknown type. On admission to the hospital at that time examination revealed no cranial or cervical bruits. A hemorrhage was observed in the right retina. The left . . .
Coping with the burden of taste alteration, a toxicity of taxane-based chemotherapy.
Authors: Rebecca M Speck, Angela DeMichele, John T Farrar, Sean Hennessy, Jun Mao, Margaret G Stineman, Frances K Barg
Journal: Journal of Clinical Oncology (2012)

e19531 Background: Taste alteration is a poorly recognized toxicity of chemotherapy, with limited research. This study examined the experience of taste alteration in female breast cancer patients treated with taxane chemotherapy. We explored the self-management coping strategies utilized by patients. Methods: A purposive sample of 25 patients currently receiving docetaxel or paclitaxel or within six months of having completed treatment was recruited. This exploratory, descriptive study utilized semi-structured interviews and patient-level data from the electronic medical record. Interview data were analyzed with the constant comparative method. Descriptive statistics were used for patient-level data. Results: Participants were 24-60 years of age, mean 46. Ten patients received docetaxel and 15 received paclitaxel. Of all side effects reported from taxanes, the most common was taste alteration (7 (70%) docetaxel patients, 3 (20%) paclitaxel patients). Taste alteration was described as a metallic taste, bad taste, weird taste, or lack of taste. Taste alteration affected normal or routine behaviors in that they chose not to eat as much, ate on an irregular schedule, and lost interest in preparing meals for themselves and/or their family. Women adopted new behaviors to deal with the taste alteration and its effect, including the use of plastic silverware, eating strongly flavored foods, honoring specific food cravings, eating candy before meals, cutting food with lemon, drinking sweetened drinks, drinking from a straw, brushing their teeth and tongue before meals, and using baking soda and salt or antibacterial mouthwash. The majority (59%) of patients gained weight during taxane treatment (mean = 2.7 lbs; range = 1-12.5 lbs). There was insufficient power to detect a difference in weight gain by taste alteration status. Conclusions: Taste alteration affects breast cancer patients’ normal routine, but they develop management strategies to deal with the effect. However, given the association of obesity with poor treatment outcomes, the potential for increased caloric consumption associated with some coping strategies is cause for concern, and further studies are warranted for the development of appropriate interventions.
Using social and mobile tools for weight loss in overweight and obese young adults (Project SMART): a 2 year, parallel-group, randomised, controlled trial
Authors: Job G Godino, Gina Merchant, Gregory J Norman, Michael C Donohue, Simon J Marshall, James H Fowler, Karen J Calfas, Jeannie S Huang, Cheryl L Rock, William G Griswold, Anjali Gupta, Fredric Raab, B J Fogg, Thomas N Robinson, Kevin Patrick
Journal: The Lancet Diabetes & Endocrinology (2016)
Treatment of mushroom poisoning
Authors: J Morland
Journal: JAMA (1985)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
In vivo comparative study of distinct polymeric architectures bearing a combination of paclitaxel and doxorubicin at a synergistic ratio
Authors: Hemda Baabur-Cohen, Laura Isabel Vossen, Harald Rune Krüger, Anat Eldar-boock, Eilam Yeini, Natalie Landa-Rouben, Galia Tiram, Stefanie Wedepohl, Ela Markovsky, Jonathan Leor, Marcelo Calderón, Ronit Satchi-Fainaro
Journal: Journal of Controlled Release (2016)
Rationale and design of the PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study) Stockholm heart failure study: an epidemiological regional study in Stockholm county of 2.1 million inhabitants
Authors: Cecilia Linde, Maria J. Eriksson, Camilla Hage, Håkan Wallén, Bengt Persson, Matthias Corbascio, Joakim Lundeberg, Eva Maret, Martin Ugander, Hans Persson
Journal: European Journal of Heart Failure (2016)
Case 10-1965
Authors: George P. Baker, Robert E. Scully
Journal: New England Journal of Medicine (1965)

Presentation of CaseA fifty-three-year-old business executive was admitted to the hospital because of persistent fever.Three weeks previously nausea, vomiting and diarrhea developed, with elevation of the temperature to 103°F. With aspirin and demethylchlortetracycline (Declomycin) the symptoms improved. He returned to work after a week but remained fatigued. During a game of golf twelve days before admission he became aware of a dull ache in both testes and in the left leg. One week later a physician examined him and found that the temperature was 100°F. A sulfonamide was administered, but the fever persisted. The pain in the lateral . . .
PD-009 Safety and efficacy of FOLFOXIRI with or without targeted agents as first-line treatment of selected elderly metastatic colorectal cancer patients: a pooled analysis of GONO studies
Authors: M. Casagrande, R. Moretto, F. Loupakis, C. Cremolini, G. Masi, B. Borelli, S. Lonardi, A. Marsico Valentina, L. Salvatore, D. Rossini, L. Ferrari, V. Ricci, R. Grande, G. Tomasello, M. Ronzoni, G. Allegrini, G. Tonini, M. Mancini, A. Zaniboni, S. Chiara, C. Carlomagno, A. Falcone
Journal: Annals of Oncology (2016)
PTU-026 Cytological yield of biliary brushings obtained during endoscopic retrograde cholangio pancreatography (ercp): a single centre experience: Abstract PTU-026 Table 1
Authors: A Sugumaran, I Thompson, A Yeoman, M Allison, M Czajkowski
Journal: Gut (2015)

<h3>Introduction</h3> British Society of Gastroenterology (BSG) guidelines recommend cytological analysis of brushings taken from biliary strictures to support diagnosis of malignancy in suspected individuals. There is wide variation reported in literature on test sensitivities ranging between 16% and 65%. We set out to report a single centre experience on the diagnostic yield of cytology specimens of biliary strictures obtained from ERCP. <h3>Method</h3> Retrospective analysis on all biliary brushings taken between 2008 and 2011 was performed. All ERCPs were performed by two experienced endoscopists. Routinely, the cytology brush is sent to the lab immediately after the procedure, analysis undertaken by liquid-based methodology and results verified by a histopathologist with special interest in pancreato-biliary disorders. The brushing result was then correlated with the final diagnosis (‘suspicious’ and ‘atypical cells’ in cytology report were considered malignant for audit purposes). <h3>Results</h3> Cytological specimens taken from 89 patients supported diagnosis of benign or malignant pathology in 67 showing an overall sensitivity of 75.3%. The sensitivity correlating with detection of any malignancy was 71%; It was higher in cholangiocarcinoma (77.8%) compared to detection of pancreatic carcinoma (71%). The other malignant pathologies encountered were ampullary carcinoma (2), hepatic metastases (2), pancreatic metastases (1), neuroendocrine tumour (1) and lymphoma (1). The specificity for malignancy was 100% and negative predictive value in diagnosing malignancy was 37.14%. <h3>Conclusion</h3> Our sensitivity and positive predictive values of biliary brushings are the highest reported to date. This could be a result of rapid processing times of our specimens and availability of a histopathologist with interest in pancreatobiliary medicine. Presence of ‘atypical cells’ can be accepted as supporting the diagnosis of malignancy in the correct clinical context, as it will improve sensitivity. In view of its simplicity and effectiveness, we recommend biliary brushing during ERCP for all biliary strictures. <h3>Disclosure of interest</h3> None Declared.
The discharged psychiatric patient: a review of social, social- psychological, and psychiatric correlates of outcome
Authors: W R Avison, K N Speechley
Journal: American Journal of Psychiatry (1987)

The authors review research over the past decade on the social, social-psychological, and psychiatric correlates of community adaptation among discharged psychiatric patients. A review of 33 studies suggests that little theoretical or methodological progress has been made in identifying the factors that are conductive to the adjustment of discharged patients on their return to the community. To stimulate subsequent efforts in this area, the authors suggest applying new approaches, such as the stress process perspective that has been used to study mental health in the general population.
Human Neural Tissue Construct Fabrication Based on Scaffold‐Free Tissue Engineering
Authors: Hironobu Takahashi, Kazuyoshi Itoga, Tatsuya Shimizu, Masayuki Yamato, Teruo Okano
Journal: Advanced Healthcare Materials (2016)

Current neural tissue engineering strategies involve the development and application of neural tissue constructs produced by using an anisotropic polymeric scaffold. This study reports a scaffold‐free method of tissue engineering to create a tubular neural tissue construct containing unidirectional neuron bundles. The surface patterning of a thermoresponsive culture substrate and a coculture system of neurons with patterned astrocytes can provide an anisotropic structure and easy handling of the neural tissue construct without the use of a scaffold. Furthermore, using a gelatin gel‐coated plunger, the neuron bundles can be laid out in the same direction at regulated intervals within multilayered astrocyte sheets. Since the 3D tissue construct is composed only by neurons and astrocytes, they can communicate physiologically without obstruction of a scaffold. The medical benefits of scaffold‐free tissue generation provide new opportunities for the development of human cell‐based tissue models required to better understand the mechanisms of neurodegenerative diseases. Therefore, this new tissue engineering approach may be useful to establish a technology for regenerative medicine and drug discovery using the patient's own neurons.
ATPS-45COMBINED INHIBITION OF WEE-1 AND PI3K SENSITIZES GLIOBLASTOMA TO APOPTOTIC CELL DEATH
Authors: Shaofang Wu, Siyuan Zheng, Shuzhen Wang, Dimpy Koul, W.K. Alfred Yung
Journal: Neuro-Oncology (2015)

Oncogenic activation of the PI3K signaling pathway plays a pivotal role in the development of glioblastoma and is a major molecular target for therapeutic development. Multiple recent reports have described mechanisms of resistance to PI3K inhibitors. The goal of the present study was to identify ways to improve the efficacy of PI3K inhibitor-based therapy by overcoming adaptive resistance. Gene expression profiling before and after PI3K inhibitor treatment was analyzed by Affymetrix microarrays to identify molecular targets contributing resistance to PI3K inhibitor. We identified WEE-1 was markedly induced after BKM treatment. Wee1 is a critical component of the G2-M cell-cycle checkpoint control and mediates cell-cycle arrest by regulating the phosphorylation of CDC2. Inhibition of Wee1 by a selective small molecule inhibitor MK1775 can abrogate G2-M checkpoint, resulting in premature mitotic entry and cell death. We show that treatment with WEE1 inhibitor MK1775 inhibited BKM-induced Cdc2 Tyr15 phosphorylation, and forced GICs to enter into the mitotic phase of the cell cycle. Using a panel of GICs, we show that MK1775 synergizes with BKM to inhibit GBM cell proliferation. Also, MK1775 and BKM as a single agent alone partially blocks proliferation, however, combination of MK1775 and BKM induces apoptosis as evaluated by Annexin V positive cells, cleaved PARP and caspase 3, and TUNEL staining. MK1775 synergized with PI3K inhibitor to extend survival in an intracranial animal model. These results indicate that WEE1 inhibition potentiated the effectiveness of PI3K targeted inhibition in GBM.
Surveillance du botulisme d'origine alimentaire en Pologne : 1960-1998
Authors: A Galazka, A Przybylska
Journal: Eurosurveillance (1999)

Contrairement aux deux autres formes de botulisme (botulisme par blessure et botulisme du nourrisson), le botulisme d’origine alimentaire chez l’homme est une intoxication resultant de l’ingestion de toxine botulinique pre-formee. Les cas sporadiques ou familiaux et les epidemies surviennent lorsqu‘un produit alimentaire est prepare ou conserve de maniere inadequate et conserve dans des conditions anaerobies favorables a la germination et a la multiplication des spores de C. botulinum, et a la production de la toxine.
Interferons in the treatment of multiple myeloma.
Authors: D E Bergsagel, P von Wussow, R Alexanian, G Avvisati, R Bataille, B Barlogie, E Borden, F Caligaris-Cappio, H Deicher, B G Durie
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.8.1444 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2380763 Interferons in the treatment of multiple myeloma. D E BergsagelxD E BergsagelSearch for articles by this author , P von WussowxP von WussowSearch for articles by this author , R AlexanianxR AlexanianSearch for articles by this author , G AvvisatixG AvvisatiSearch for articles by this author , R BataillexR BatailleSearch for articles by this author , B BarlogiexB BarlogieSearch for articles by this author , E BordenxE BordenSearch for articles by this author , F Caligaris-CappioxF Caligaris-CappioSearch for articles by this author , H DeicherxH DeicherSearch for articles by this author , B G DuriexB G DurieSearch for articles by this author Show More https://doi.org/10.1200/JCO.1990.8.8.1444 PDF "Interferons in the treatment of multiple myeloma.." Journal of Clinical Oncology, 8(8), pp. 1444–1445© 1990 by American Society of Clinical Oncology
Endosonography-guided choledochoduodenostomy versus a transphincteric approach
Authors: Ulku Saritas, Yucel Ustundag
Journal: Endoscopy (2016)

We read with interest the article by Kawakubo et al. on endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) versus transpapillary stenting (TPS) for distal biliary obstruction [1]. The authors studied a cohort of 82 patients and compared 26 patients who underwent EUS-CDS with 56 patients who underwent TPS. They found that both groups had similar rates of clinical success (96.2 % vs. 98.2 %), 1-year re-intervention (16.6 % vs. 13.6 %), and adverse events (26.9 % vs. 35.7 %). However, the EUS-CDS group in this study was noted to have shorter procedure times with no risk of pancreatitis.
Incidence and Risk Factors For Veno-Occlusive Disease Of The Liver After Allogeneic Stem Cell Transplantation Using a Reduced Intensity Regimen
Authors: Panagiotis Tsirigotis, Igor B Resnick, Batia Ronit Avni, Sigal Grisariu, Polina Stepensky, Reuven Or, Michael Y Shapira
Journal: Blood (2013)