tbuckley/cabot-search huggingface dataset:
EL INDICE DE MASA CORPORAL (IMC) Y EL SEXO NO INFLUYEN EN LA CALIDAD DE LA PREPARACÓN DE UNA COLONOSCOPIA REALIZADA CON DOS DOSIS SEPARADAS DE DOS LAXANTES DE CONTACTO (PICOSULTATO Y BISACODILO)
Authors: S Rodríguez Muñoz, T Álvarez Malé, M Sánchez Cazalilla
Journal: Endoscopy (2013)

Introducción: Tanto el Índice de Masa Corporal (IMC), como la edad y el sexo influyen en el riesgo de padecer cáncer colorrectal y adenomas. Por otro lado la forma en que afectan a la práctica de una colonoscopia permanece en discusión. Objetivos: Verificar el efecto del IMC, la edad, el sexo y la presencia de divertículos en la calidad de la preparación de los pacientes y en la tasa de detección de adenomas. Material y Método: Realizamos un estudio prospectivo sobre 328 colonoscopias consecutivas en pacientes para cribado y con síntomas, sobre las que realizamos un estudio de regresión multivariante. El IMC se calculó en Kg/m2, el grado de limpieza del colon se calculó mediante la escala de Boston. También agrupamos a los pacientes por categorías para el IMC (delgados, normopeso, sobrepeso y obesos) y para la limpieza en limpios (Boston ≥7) y sucios (Boston ≤6). La presencia de divertículos, el número total de pólipos y el tamaño del mayor detectado se emplearon como covariables adicionales. Resultados: El IMC no influyo en el grado de preparación medido bien por la escala de Boston bien agrupados por categorias (IMC limpios 25,42 ± 3,79 IMC sucios 25,34 ± 4,11, p = 0.84). El sexo y la presencia de divertículos tampoco influyeron en el grado de preparación. Los mayores de 65 años acudían peor preparados p < 0.006). Tanto el IMC (p = 0.006), como el sexo (p < 0.0001), la edad (p = 0.018) y un mejor grado de preparación (p = 0.05) se asociaron a un mayor número de pólipos resecados durante la colonoscopia. Un IMC alto se asociaba a un mayor número de adenomas planos mayores de 9 mm (p = 0.01). Conclusiones: La preparación con dos laxantes de contacto en dosis separadas elimina los efectos sobre la calidad de la misma relacionados con los factores dependientes del enfermo con la excepción de los asociados con la edad.
Rubidium-82 Uptake in Metastases From Pheochromocytoma on PET Myocardial Perfusion Images
Authors: Amit Gupta, Frank P. DiFilippo, Richard C. Brunken
Journal: Clinical Nuclear Medicine (2011)

Rubidium-82 (Rb-82) is commonly used for PET myocardial perfusion imaging. A 61-year-old male patient with coronary artery disease underwent cardiac Rb-82 PET myocardial perfusion and FDG PET myocardial viability scan. Besides myocardium, prominent Rb-82 uptake was identified in several pleural and osseous lesions. These were confirmed to be metastases from pheochromocytoma on the FDG PET and noncontrast CT scan. Chart review revealed that the patient had history of pheochromocytoma for more than 40 years, with widespread metastases as demonstrated by various imaging findings. The latest biopsy from an extradural spinal mass also demonstrated metastatic pheochromocytoma.
Partner selection, coordination games, and group selection
Authors: Michael S. Alvard
Journal: Behavioral and Brain Sciences (2013)

Abstract The process of partner selection reflects ethnographic realities where cooperative rewards obtain that would otherwise be lost to loners. Baumard et al. neglect frequency-dependent processes exemplified by games of coordination. Such games can produce multiple equilibria that may or may not include fair outcomes. Additional, group-selection processes are required to produce the outcomes predicted by the models.
Abstract LB-44: Sister to sister
Authors: Lori A. Whaley
Journal: Cancer Research (2012)

Abstract Mission Statement: To empower the minority community to take a more active role in meeting their health needs. Goals: To educate African American women &amp; families about the importance of early detection of breast cancer, breast self-exam (BSE), clinical breast exam (CBE) and mammograms; to inspire and recruit survivors to participate in Women In Touch (WIT); to educate and gain the trust of minority women about enrolling in clinicals trials. Our Services: Wig bank, protheses, transportation, health care symposium, presentations at churches or civic groups, support group meetings, quarterly newsletters and financial assistance referrals. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-44. doi:1538-7445.AM2012-LB-44
SAT0211 Hematological abnormalities in 624 patients with systemic lupus erythematosus and their relationship with organ involvement:
Authors: A. Alarfaj, A. Aleem, N. Khan
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Hematological abnormalities are common in SLE [1-4]. <h3>Objectives</h3> To find out the hematological abnormalities and their relationship in a large cohort of Saudi SLE patients. <h3>Methods</h3> SLE Patients (fulfilling ACR criteria)attending KKUH clinics, Riyadh,between 1980-2006 were studied. Demographic, hematological, and clinical manifestations were collected. <h3>Results</h3> A total of 624 patients, 566 (90.7%) females, were diagnosed to have SLE with a mean age of 34.3±11.9 (range 8-71) years, and mean duration of SLE of 9.3±5.3 (range 0.3-30) years. Of these patients, 516 (82.7%) had hematological abnormalities at the time of diagnosis (Table 1). Anemia (Hb &lt;12 gm/dL), occurred in 63% patients. leucopenia (WBC &lt;4 ×10<sup>9</sup>/L) in 30%, lymphopenia (&gt;1.5×10<sup>9</sup>/L) in 40.3%, thrombocytopenia (platelets &lt;100×10<sup>9</sup>/L) in 10.9% and autoimmune hemolytic anemia (AIHA) in 4.6% patients. C3 and C4 hypocomplimentemia was seen in 45.4% and 42.2% patients respectively. Deep venous thrombosis (DVT) developed in 46 (7.4%) patients, pulmonary embolism in 16 (2.6%) and antiphospholipid syndrome was diagnosed in 257 (41.2%) patients. Twelve patients developed TTP, 3 patients had Evans syndrome and 3 Budd-Chiari syndrome. In multivariate analysis leucopenia was associated with oral ulcers and alopecia, anemia with renal disease, AIHA with neurological involvement, elevated IgG with malar rash and low C3 with serositis (for all p&lt;0.05). <h3>Conclusions</h3> Among hematological manifestations of SLE, Anemia was the most common, followed by lymphopenia,leucopenia and thrombocytopenia.Patients with leucopenia were more likely to develop oral ulcers and alopecia, anemia predicted renal disease and AIHA was associated with neurological involvement. <h3>References</h3> Fernández M, Alarcόn GS, Calvo-Alén J, et al (2007) LUMINA Study Group. A multiethnic, multicenter cohort of patients with systemic lupus erythematosus (SLE) as a model for the study of ethnic disparities in SLE. Arthritis Rheum 57:576-584 Al Arfaj AS, Khalil N (2009) Lupus18:465-473 Sultan SM, Begum S, Isenberg DA (2003) Prevalence, patterns of disease and outcome in patients with systemic lupus erythematosus who develop severe haematological problems. Rheumatology (Oxford) 42:230-234 Tan EM, Cohen AS, Fries JF, et al (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277 <h3>Disclosure of Interest</h3> None Declared
Abstract SY06-01: Intracellular antibody therapy: Specific delivery of synthetic antibodies to cytoplasmic targets in cancer cells
Authors: Anthony A. Kossiakoff
Journal: Cancer Research (2012)

Abstract Synthetic Antigen Binders (sABs) are a new class of antibody-based reagents engineered using novel phage display libraries and selection strategies. These attributes provide for the ability to generate sABs that are customized to: 1) target specific regions on the surface of the protein, 2) recognize specific conformational or oligomeric states, 3) induce conformational changes, and 4) capture and stabilize multi-protein complexes. As such, they have the potential to outperform traditional monoclonal antibodies as therapeutic modalities for biomedical applications. However, a critical limitation is that antibodies can only be directed at extracellular targets because they cannot penetrate the cell membrane. This eliminates a rich set of potential cytoplasmic targets that function as crucial components of signaling pathways or structural networks. To overcome this limitation we have developed receptor-mediated delivery systems that have proven effective in internalizing a novel class of synthetic antigen binders in their fully functional form. Further, this delivery system inherently seeks out certain types of cancer cells, while being inert towards cells on normal tissue. As a demonstration of the power of the approach, we have generated a set of sABs that have been tailored to induce conformational changes in F-actin filaments that substantially alter actin cytoskeletal structure by mechanisms involving depolymerizing, severing, bundling and capping of actin filaments. We introduce these sABs into cancer cells using receptor-mediated delivery and show the properties selected for in the in vitro phage display sorting are exactly recapitulated in the live cells. The effects of actin filament bundling are shown to be particularly detrimental to the cancer cells suggesting that sABs performing this function may be useful therapeutic agents. This approach is being expanded to make agents that target nuclear components to alter cell function at the DNA level. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr SY06-01. doi:1538-7445.AM2012-SY06-01
AB0600 How do General Practitioners Identify GIANT Cell Arteritis (GCA)?
Authors: T. Helliwell, S. Muller, S.L. Hider, J. Richardson, C. Mallen
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Giant Cell Arteritis (GCA) is the commonest large vessel vasculitis yet a full time UK general practitioner (GP) can expect to see just 1 case every 1-2 years [Barraclough]. GCA may be difficult to identify, particularly in atypical cases. For example headache has been shown to be absent in just under a quarter of GCA patients which may falsely reassure clinicians resulting in delayed diagnosis and potential visual loss [Ezeonyeji]. <h3>Objectives</h3> The aim of this study was to investigate how GPs identify GCA. <h3>Methods</h3> A postal questionnaire survey of 5000 randomly selected UK general practitioners was undertaken. Questions included experience of managing patients with GCA, presenting symptoms used to identify GCA and the referral pathways used. <h3>Results</h3> 1249 questionnaires were returned. The mean age of responder was 43 years and they had been qualified as a GP for a mean of 14 years (SD 9.03). Respondents were more likely to be from larger practices. 879 responders (70.4%) indicated that they had diagnosed and managed a patient with GCA. Figure 1 illustrates the combinations of the main symptoms that GPs use to identify GCA with headache being the predominant feature (n=1071 (86%)). Other commonly reported features were visual disturbances (n=671 (53.9%)), jaw symptoms (n=420 (33.7%)) and temporal artery/scalp tenderness (n=468 (37.6%)). 21.86% (n=273) indicated that they only use headache as a symptom for identifying GCA. <h3>Conclusions</h3> General practitioners in the UK rely overly on headache when diagnosing GCA. Educating clinicians about other presenting symptoms and atypical presentations is essential to optimise diagnosis and reduce the potential for visual loss for this patient group and to reduce potentially serious long term complications. <h3>References</h3> Barraclough K et al. Br J Gen Pract. 2012 Jun;62(599):329-3 Ezeonyeji A et al. Clin Rheumatol. 2011;30(2):259-262 <h3>Acknowledgements</h3> Administration and support staff at Keele University Department of Primary Care and Health Sciences. IT Staff Zoe Mason and Ashley Ford. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4634
Sunburst Periosteal Reaction in a Bony Metastasis
Authors: R Breit, H Van Der Wall, L Emmett, G Storey, K Allman
Journal: Clinical Nuclear Medicine (2000)

A 92-year-old man with a painful right hip reported a history of transitional cell carcinoma of the kidney that had been surgically excised 6 years previously. Plain radiographs revealed a region of mixed cortical lysis and sclerosis with a widened transition zone and the periosteal sunburst reaction. Bone scintigraphy showed intense uptake in the right femur, extending into the soft tissues. Other sites of uptake compatible with metastases were also present. Biopsy of the femoral lesion confirmed metastatic transitional cell carcinoma.
INDOMETACINA ENDO-RECTAL COMO PROFILAXIS DE LA PANCREATITIS POST-ERCP. ¿ES NECESARIA SU APLICACIÓN UNIVERSAL O SÓLO A PACIENTES DE ALTO RIESGO? ESTUDIO PROSPECTIVO ALEATORIZADO
Authors: E Albéniz, H León-Brito, J Eguaras, C Jiménez, A Pueyo, M Fraile, A Ciáurriz, I Aresté, MP Huarte, MJ Burusco
Journal: Endoscopy (2012)

Introducción: Diversos estudios recomiendan la utilización de AINEs como el diclofenaco y la indometacina por vía rectal en la prevención de la pancreatitis aguda post-CPRE (PPCPRE). El número de participantes incluidos ha sido escaso en algunos trabajos y en otros sólo se han seleccionado pacientes de alto riesgo de presentar PPCPRE. Objetivo: Determinar si la administración de indometacina endo-rectal al inicio de una CPRE previene la aparición de PPCPRE en pacientes no seleccionados. Material y método: Realizamos un estudio prospectivo aleatorizado doble-ciego asignando a los pacientes sometidos a CPRE terapéutica a uno de los dos grupos de interés: tratamiento (supositorio de indometacina 100mg al inicio de la prueba) o placebo (supositorio de glicerina). Se analizaron los factores de riesgo conocidos para el desarrollo de PPCPRE. El objetivo principal fue la aparición o no de pancreatitis aguda. La valoración de la PPCPRE y la recogida de los datos la realizaron médicos que no efectuaron las endoscopias. Resultados: Entre enero y julio de 2012 se realizaron 148 CPRE en nuestro centro con una tasa de éxito terapéutico del 91,2%. 83 pacientes recibieron placebo y 65 tratamientos. Se registraron 7 pancreatitis agudas leves, lo que supone una tasa de PPCPRE del 4,7%; 2 casos en el grupo de tratamiento (3,1%) y 5 en el grupo placebo (6%). No hubo diferencias significativas entre el resto de factores de riesgo de PPCPRE estudiados (edad, sexo, antecedentes personales, indicación de la CPRE y grado de dificultad (ASGE), dilatación de la vía biliar, presencia o no de cálculos, dificultad de canulación, experiencia del endoscopista, etc.). La administración de indometacina no originó ningún efecto adverso. Conclusiones: A pesar de que observamos el doble de PPCPRE en el grupo placebo que en el de tratamiento, el número de eventos recogidos es aún insuficiente para alcanzar significación estadística. Consideramos útil continuar con este estudio que incluye a pacientes de riesgo estándar de PPCPRE, para comprobar si esta medida profiláctica debe aplicarse al inicio de cualquier CPRE.
Intense FDG Activity in the Brown Adipose Tissue in Omental and Mesenteric Regions in a Patient With Malignant Pheochromocytoma
Authors: Wuying Cheng, Zhaohui Zhu, Xiaona Jin, Libo Chen, Hongming Zhuang, Fang Li
Journal: Clinical Nuclear Medicine (2012)

A 39-year-old man who had a history of surgical excision of left adrenal pheochromocytoma 3 years ago underwent an FDG PET/CT scan to evaluate possible metastatic/recurrent disease. In addition to multiple FDG-avid lesions typical of hypermetabolic malignant disease and the FDG uptake in regions rich in brown adipose tissue, there was also intense FDG activity in the omental and mesenteric regions, which are not common locations of elevated FDG activity. On the repeat FDG PET/CT scan 3 days later after the patient was prepared with propranolol, the omental and mesenteric FDG activity was diminished.
AB1397 Use of WII fit® in balance training in osteoporosis:
Authors: R. Laxminarayan, H. Nutland, A. Dean
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Main objective of osteoporosis treatment is to reduce fragility fractures. Pharmacological interventions though increase bone mineral density, falls contribute significantly to fractures. Balance training is an important part of physiotherapy intervention for osteoporosis. Traditional balance training may not appeal to many patients. Gaming console maker Nintendo® has developed a unique balance board based games called Wii Fit®. This interactive balance training gadget is easy to use and maintains individual's interest. We wanted to explore the usefulness of Wii Fit® in improving the balance in osteoporosis patients. <h3>Objectives</h3> To assess benefits of Wii Fit® tilt table function in improving balance in osteoporosis patients. <h3>Methods</h3> Wii Fit® balance training programme was started in April 2011. Consecutive Osteoporosis patients attending physiotherapy sessions were invited to attend Wii Fit® sessions. Prior to starting the sessions, they all had an opportunity to attend education programme on osteoporosis. Baseline balance was assessed using Timed up and go (TUG), Tinnetti balance score, balance on one leg (measured for each leg in seconds). In addition, time on tilt table on Wii Fit® was also measured. Each patient had total 6 weekly sessions on the Wii Fit®. Above measurements were taken on each visit. Mean baseline and final measurements were calculated. <h3>Results</h3> 18 patients completed the programme between April to December 2011. <h3>Conclusions</h3> Wii Fit® tilt table exercise improves balance as shown in the above table. Improvements were noticed in every assessment mode. Subjectively patients enjoyed the exercise sessions. Patients were able to see the improvements on the screen which also helped to improve their confidence. <h3>Disclosure of Interest</h3> None Declared
Abstract 4212: Characterization of the gene expression network that underlies cancer cell-platelet interactions and cancer progression
Authors: Bertrand Tan, Hsuan Liu, Wen-Hsin Wu
Journal: Cancer Research (2012)

Abstract Understanding how cancer cells outgrow and escape from the primary site is important for development of novel therapeutic scheme. Our recent results from microarray-based gene expression profiling analysis demonstrate differential expression of a cohort of genes (∼220) in the circulating tumor cells, many of which play a role in haemostasis and thrombosis. To screen for putative transcription factors that might contribute to the metastasis-associated gene expression alterations (and possibly the upregulation of haemostatis-associated genes), we first undertook bioinformatics approach by analyzing differentially expressed genes using GeneGo. From the list of potential transcription factors that are identified from the bioinformatics approach, we selected two TFs (CREB and Sp1) for further studies. Consistent with the upregulation of selected genes, ChIP analyses demonstrated promoter occupancy by these two TFs, and further a greater degree of binding in the circulating/metastatic tumor cells. These results suggest their link to the transcriptional induction of the target genes in these cells. Interestingly, we also discovered that the levels of c-fos and Ser15 phosphorylation on p53 underwent an increase in these cells. To dissect the signaling pathways that may underlie the observed transcriptomic alteration, we again applied gene ontology analysis to pinpoint possible signaling networks. Such profiling demonstrated an elevation of the TGFβ2/BMP pathway and a downregulation of EGFR/ErbB signaling in circulating cells compared with the parental line, possibly suggesting a role of the corresponding pathways in the transcriptomic as well phenotypic changes in the metastatic cells. In addition, changes in the expression of several signaling cascade intermediates - Akt, Erk, JNK - were also evident based on immunoblotting results. Our preliminary results have revealed the potential involvement of several transcription factors and signaling pathways in our metastasis experimental model. Discussion of their implications and future work is also included. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4212. doi:1538-7445.AM2012-4212
P87 DETECTION OF CIRCULATING TUMOUR CELLS (CTCS) IN HEPATOCELLULAR (HCC) CANCER PATIENTS USING THE IMAGESTREAM
Authors: L. Ogle, D. Jamieson, R. O'Donnell, B. Dent, A. Boddy, N. Curtin, R. Plummer, H. Reeves
Journal: Journal of Hepatology (2014)
CONTEMPORARY PRACTICE PATTERNS RELATED TO THE RISK OF ACUTE KIDNEY INJURY IN THE CATHETERIZATION LABORATORY: RESULTS FROM AN INTERNATIONAL SURVEY OF SOCIETY OF CARDIOVASCULAR ANGIOGRAPHY AND INTERVENTION (SCAI) CARDIOLOGISTS
Authors: Anand Prasad, Jonathan Morales, Ken Williams, Aaron Sohn, Daniel Levin, Aazib Khan, Peter McCullough, Roxana Mehran, Steven Bailey
Journal: Journal of the American College of Cardiology (2016)
Abstract 1628: Molecular cross-talk between head and neck squamous cell carcinoma cells and cancer-associated fibroblasts.
Authors: Anna Ansell, Matti Kankainen, Outi Monni, Ann-Charlotte Johansson
Journal: Cancer Research (2013)

Abstract One of the main components of the tumor stroma is the cancer-associated fibroblasts (CAFs), which are known to stimulate tumor cell proliferation, angiogenesis and metastasis. Increasing evidence suggests that CAFs also influence the tumor cell response to various treatments. In this study we aimed to characterize the molecular cross-talk between CAFs and head and neck squamous cell carcinoma (HNSCC) cells. Tumor cell lines and CAF cultures were established from tumor biopsies derived from five HNSCC patients at Linköping University Hospital. Patient-matched tumor cells and CAFs were co-cultured for seven days in cell culture flasks, allowing cell-cell contact. After cell sorting the gene expression in mono-cultured and co-cultured tumor cells was investigated by Affymetrix microarray. Molecular networks were analyzed by Ingenuity Pathway Analysis (IPA). The expression of selected genes was verified by quantitative real-time PCR (qPCR) analysis. Fiftyeight genes were found to be differentially expressed (q&amp;lt;0.05) in tumor cells co-cultured with CAFs when compared to tumor cells in mono-culture. The top functions of these genes were cancer, cellular movement, and embryonic development as analyzed by IPA. Four genes (POSTN, GREM1, COL1A2, and COL6A3) were upregulated by more than 2-fold while 14 genes were found to be downregulated by at least 50%. The four upregulated genes have all been associated with epithelial-to-mesenchymal transition (EMT), increased migration, and TGFβ-pathway signaling. By qPCR analysis the expression of POSTN, GREM1 and COL1A2 was found to be induced by several hundred-fold in some of the cell lines under co-culture conditions. There were no significant changes in the expression of these genes when tumor cells and CAFs were co-cultured in a trans-well system, suggesting that the effect may be contact-dependent. Functional analyses are now being performed to determine the importance of these findings. Citation Format: Anna Ansell, Matti Kankainen, Outi Monni, Ann-Charlotte Johansson. Molecular cross-talk between head and neck squamous cell carcinoma cells and cancer-associated fibroblasts. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1628. doi:10.1158/1538-7445.AM2013-1628