tbuckley/cabot-search huggingface dataset:
Soundings: Quite a good camp
Authors: Colin Douglas
Journal: BMJ (2002)

She was a tall, quiet lady, almost stately. She had come a long way: from somewhere in Poland she had been taken to Siberia, escaped west somehow and joined the millions of refugees loose in Europe in the mid 1940s, and then for good reasons had found her way to Scotland.

Our Polish community dates from that war. A Polish army garrisoned the east coast from Aberdeen to the border, and when Poland fell to communism many chose to stay. They settled, married locally, and grew old. The wartime generation has now largely faded; and a successor generation integrated without difficulty.

From time to time I still come across survivors with tales to tell: like the cavalryman who rode out against tanks in 1939; or the officer from the Polish armoured brigade that held the northern strongpoint of the Falaise gap in 1944, wreaking terrible, long awaited vengeance on the retreating Wehrmacht.

Our tall, stately lady did not talk much. After a hip fracture she was too frail and confused to go straight home to her little flat in Marchmont. In a rehabilitation ward, making little progress herself, she was watchful and, in her muddled way, alert.

She would listen carefully when spoken to, as though trying first to work out what language was in use. She replied in English or Polish, more often the latter as time went by. At night she was reportedly more anxious than she was by day. Sometimes, but only at night, she became quite distressed.

As weeks passed her behaviour became odder. She was reluctant to part with things that should not have mattered, like used tissues, and explained angrily why, but not in English. In theory she should have gone to a nursing home, but there were concerns about her agitation.

We took a liberal view of official guidance and in due course transferred her to an NHS long term care bed. In her new placement she was at first nervous but later settled, adapting to the routines of ward life, occasionally helping other patients—it seems that at some point before or during the war she had done some nursing—though she remained wary of men in dark suits.

In her last months she started to hide scraps of food in odd places. Eventually she declined to a final illness. By then she was calm. In one of her last conversations in English she told someone she thought this camp was quite good, and the guards very kind.
Phenylethylamine in rhesus monkeys: interactions with alpha-methyl-para- tyrosine and l-dopa
Authors: J R Tinklenberg, J C Gillin, G M Murphy, R Staub, R J Wyatt
Journal: American Journal of Psychiatry (1979)

Rhesus monkeys, pretreated with alpha-methyl-para-tryosine (AMPT) and subsequently injected with phenylethylamine (PEA), did not demonstrate the characteristic amphetamine-like PEA effects. However, when AMPT pretreatment was followed with l-dopa and then PEA injection, PEA effects were restored. These results are compatible with a dopamine theory of schizophrenia.
Relative performance of for-profit psychiatric hospitals in investor- owned systems and nonprofit psychiatric hospitals
Authors: M J McCue, J P Clement
Journal: American Journal of Psychiatry (1993)

The authors analyzed the differences in operational and financial performance between 42 matched pairs of for-profit psychiatric hospitals belonging to multifacility organizations and nonprofit psychiatric hospitals for the fiscal years ending in 1986 through 1990.The pairs of short-term hospitals were matched according to location, standard metropolitan statistical area, or wage index. Analyses were based on data on these hospitals from the Health Care Financing Administration. The groups of variables studied included the hospitals' operational performance and productivity, profitability and payer mix, revenue and expenses, and capital structure. Differences in the mean values of the variables for the for-profit hospitals and the nonprofit hospitals were analyzed by pairwise t tests.The for-profit organization hospitals had significantly higher net revenue, lower salary expenses, and higher profits than the nonprofit hospitals. Patients in the for-profit hospitals had longer stays, and these hospitals had fewer full-time employees per adjusted inpatient day and per adjusted discharge.The higher prices and operating margins of the for-profit hospitals belonging to investor-owned systems reflect the profit-maximizing goal of these facilities. The ability of for-profit organization hospitals to achieve economies of scale in expenses, however, was not evident except in the case of salary expenses.
BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction
Authors: Lehanna N. Sanders, John A. Schoenhard, Mohamed A. Saleh, Amrita Mukherjee, Sergey Ryzhov, William G. McMaster, Kristof Nolan, Richard J. Gumina, Thomas B. Thompson, Mark A. Magnuson, David G. Harrison, Antonis K. Hatzopoulos
Journal: Circulation Research (2016)

We have recently shown that the bone morphogenetic protein (BMP) antagonist Gremlin 2 (Grem2) is required for early cardiac development and cardiomyocyte differentiation. Our initial studies discovered that Grem2 is strongly induced in the adult heart after experimental myocardial infarction (MI). However, the function of Grem2 and BMP-signaling inhibitors after cardiac injury is currently unknown.To investigate the role of Grem2 during cardiac repair and assess its potential to improve ventricular function after injury.Our data show that Grem2 is transiently induced after MI in peri-infarct area cardiomyocytes during the inflammatory phase of cardiac tissue repair. By engineering loss- (Grem2(-/-)) and gain- (TG(Grem2)) of-Grem2-function mice, we discovered that Grem2 controls the magnitude of the inflammatory response and limits infiltration of inflammatory cells in peri-infarct ventricular tissue, improving cardiac function. Excessive inflammation in Grem2(-/-) mice after MI was because of overactivation of canonical BMP signaling, as proven by the rescue of the inflammatory phenotype through administration of the canonical BMP inhibitor, DMH1. Furthermore, intraperitoneal administration of Grem2 protein in wild-type mice was sufficient to reduce inflammation after MI. Cellular analyses showed that BMP2 acts with TNFα to induce expression of proinflammatory proteins in endothelial cells and promote adhesion of leukocytes, whereas Grem2 specifically inhibits the BMP2 effect.Our results indicate that Grem2 provides a molecular barrier that controls the magnitude and extent of inflammatory cell infiltration by suppressing canonical BMP signaling, thereby providing a novel mechanism for limiting the adverse effects of excessive inflammation after MI.
Molecular biology of renal injury
Authors: J R Ingelfinger, V J Dzau
Journal: Journal of the American Society of Nephrology (1991)

The developments in molecular biology of the past decade have created a powerful technology with important, if not revolutionary, clinical applications. This review discusses the molecular biology of renal injury focusing on the renin-angiotensin system as a model, first considering the molecular physiology of the renin angiotensin system within the kidney and then considering its abnormalities in renal injury. All of the components of the renin-angiotensin system are present within the kidney and are involved in modulation of glomerular microcirculation, in proximal tubular reabsorptive function, in control of glomerular/tubular balance, in modulation of medullary blood flow, and in growth and repair of the renal tubule. A new understanding of these multiple roles of the renin-angiotensin system within the kidney is made feasible by combining physiological studies with techniques such as mRNA analysis (e.g., Northern and slot blots, in situ hybridization, and RNA protection assays), transgenic animal studies, transfection studies, and restriction fragment length polymorphism analysis. The ways in which such approaches have been used to examine the role of the renin-angiotensin system in acute renal failure, proteinuric states, renal hypertension, and diabetes mellitus are discussed.
Acute Treatment of Patients With Supraventricular Tachycardia
Authors: Sana M. Al-Khatib, Richard L. Page
Journal: JAMA Cardiology (2016)

This Clinical Guideline summarizes the 2015 American College of Cardiology/American Heart Association/Heart Rhythm Society Guideline for the Management of Adult Patients With Supraventricular Tachycardia.
Pharmacokinetic study of lorazepam overdosage
Authors: M D Allen, D J Greenblatt, Y LaCasse, R I Shader
Journal: American Journal of Psychiatry (1980)

The authors describe three patients who attempted to commit suicide by ingesting overdoses of lorazepam, an intermediate-acting benzodiazepine that, unlike diazepam, has no active metabolites. All three patients were clinically well within 24-30 hours of ingestion, although high lorazepam concentrations persisted. The authors point out that the elimination half-life of lorazepam after extremely high doses have been ingested is approximately the same as that found after ingestion of usual therapeutic doses.
Functional Genomics of Wood Quality and Properties
Authors: Wei Tang, Xiaoyan Luo, Aaron Nelson, Hilary Collver, Katherine Kinken
Journal: Genomics Proteomics & Bioinformatics (2003)

Abstract Genomics promises to enrich the investigations of biology and biochemistry. Current advancements in genomics have major implications for genetic improvement in animals, plants, and microorganisms, and for our understanding of cell growth, development, differentiation, and communication. Significant progress has been made in the understanding of plant genomics in recent years, and the area continues to progress rapidly. Functional genomics offers enormous potential to tree improvement and the understanding of gene expression in this area of science worldwide. In this review we focus on functional genomics of wood quality and properties in trees, mainly based on progresses made in genomics study of Pinus and Populus. The aims of this review are to summarize the current status of functional genomics including: (1) Gene discovery; (2) EST and genomic sequencing; (3) From EST to functional genomics; (4) Approaches to functional analysis; (5) Engineering lignin biosynthesis; (6) Modification of cell wall biogenesis; and (7) Molecular modelling. Functional genomics has been greatly invested worldwide and will be important in identifying candidate genes whose function is critical to all aspects of plant growth, development, differentiation, and defense. Forest biotechnology industry will significantly benefit from the advent of functional genomics of wood quality and properties.
Absence of the gamma-Leu 427 (gamma') variant in the platelet alpha- granular fibrinogen pool supports the role of glycoprotein IIB/IIIA in mediating fibrinogen uptake into platelets/megakaryocytes [letter; comment]
Authors: P Harrison, BR Wilbourn, RH Saundry, AS Lawrie, GF Savidge
Journal: Blood (1992)
Ischemia and Infarction in STEMI Patients With Multivessel Disease
Authors: Andrew D. Kelion, Mini V. Pakkal, Fahmid U. Chowdhury, James D. Birchall, Katherine L. Dixon, Florence Y. Lai, Damian J. Kelly, Marcus Flather, Gerry P. McCann, Anthony H. Gershlick
Journal: Journal of the American College of Cardiology (2016)
AB0997 Children with Psoriasis and Arthritis – an Important Clinical and Prognostic Issue That Challenges the Ilar-Classification
Authors: M. Ekelund, K. Aalto, A. Fasth, T. Herlin, S. Nielsen, E. Nordal, S. Peltoniemi, M. Rygg, M. Zak, L. Berntson
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Among pediatric rheumatologists there is an on-going discussion whether juvenile psoriatic arthritis is an entity of its own or not. It is recognized that psoriatic arthritis is a disease with both autoimmune and autoinflammatory features. The ILAR-classification of psoriatic arthritis is under debate. <h3>Objectives</h3> To study clinical signs, classification, and outcome in children with juvenile idiopathic arthritis (JIA) and psoriasis/psoriasis-like rash in a population-based cohort during the first eight years of disease. <h3>Methods</h3> In total 440 children with JIA were included prospectively in a population-based cohort study. The presence of psoriasis and psoriasis-like rash during an eight years follow-up period was assessed in relation to clinical characteristics, ILAR-classification and remission. <h3>Results</h3> - Of the 440 children 14 developed psoriasis and 13 psoriasis-like rash during the first eight years of disease. 8/14 children with psoriasis and JIA were classified as juvenile psoriatic arthritis (JPA). 6/14 children with psoriasis and JIA were classified as undifferentiated JIA. One was RF positive and the other five had concurrent signs of enthesitis-related arthritis. Children with dactylitis and/or nail-pitting were spread among many ILAR categories. Children with JIA and psoriasis/psoriasis-like rash had significantly higher number of cumulative active joints during the first eight years from disease onset than children with no psoriasis/psoriasis-like rash (p=0.02). Dactylitis, nail pitting and enthesitis were significantly more common (0.01, &lt;0.001, 0.03) in children with psoriasis/psoriasis-like rash compared to the rest of the cohort. Children with and without psoriasis/psoriasis-like rash had the same outcome with regards to remission status after eight years. <h3>Conclusions</h3> ILAR-criteria exclude children with spondylitis and enthesitis-related features from the JPA category. We suggest that this is not clinically relevant. Our results indicate a more severe disease course in children with psoriasis/psoriatisis-like rash and JIA, but the number of children with psoriasis/psoriasis-like rash was limited. There is a need to study children with psoriasis and arthritis in more detail regarding clinical pattern and prognosis. <h3>Disclosure of Interest</h3> None declared
A critique of the process-oriented approach to ward staff meetings
Authors: R C Abrams, J A Sweeney
Journal: American Journal of Psychiatry (1982)

Interdisciplinary staff meetings with a group-process orientation are a common feature of inpatient psychiatric wards. In these meetings an attempt is made to elicit and resolve intrastaff conflicts. Often the hierarchy of administrative structure is suspended and a setting reminiscent of a therapy or T-group is created. Insufficient attention has been paid to the potential hazards of and varying indications for this process-oriented approach to staff meetings. The authors reassess the usefulness of these meetings in improving staff relations and clinical performance and suggest guidelines for tailoring their use to fit the ward's therapeutic objectives.
Calling for a developmental perspective on action-based consciousness
Authors: Hana D'Souza, Andrew J. Bremner
Journal: Behavioral and Brain Sciences (2016)

Human newborns can resolve some response conflicts in order to adapt their behaviour, suggesting that the newborn has consciousness according to Morsella et al.'s framework. However, we pose a range of developmental questions regarding Morsella et al.'s account, especially concerning the role of consciousness in the development of action.
A Unifying Concept of the Etiology of the Leukemias, Lymphomas, and Cancers&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: E. E. Osgood
Journal: JNCI Journal of the National Cancer Institute (1957)

A Unifying Concept of the Etiology of the Leukemias, Lymphomas, and Cancers E. E. Osgood E. E. Osgood Division of Experimental Medicine, University of Oregon Medical School, Portland, Oregon Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 2, February 1957, Pages 155–166, https://doi.org/10.1093/jnci/18.2.155 Published: 01 February 1957 Article history Received: 10 August 1956 Published: 01 February 1957
AB0942 Pyogenic Infections of the Pubic Symphysis: Clinical and Therapeutic Features
Authors: Z. Alaya, I. Henchiri, H. Zaghouani, K. Baccouche, S. Belghali, D. Amri, H. Zeglaoui, E. Bouajina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Septic arthritis of the pubis symphysis is rare and difficult to diagnose. It follows in most cases pelvis surgery or delivery. <h3>Objectives</h3> The objective of our study was to describe the biological, therapeutic, clinical and radiological aspects of pyogenic infections of the pubic symphysis. <h3>Methods</h3> This is a retrospective study of 4 cases of pyogenic infections of the pubic symphysis collected in the Department of Rheumatology over a period of 14 years [2000-2014]. <h3>Results</h3> Our population consists of 3 women and one men. The mean age was 47 years [18-83]. No comorbidity was recorded. Clinical signs of appeal were inflammatory groin pain, pubic pain and fever. Symptoms appeared 2 weeks after forceps delivery complicated by infectious endometritis in 2 cases, after surgery on the pelvis in one case and in a context of sepsis in one case. Walking was impossible in 2 cases. The mobilization of the hips and the pressure at the pubic symphysis were painful. The biological inflammatory syndrome was present in all cases. Plain radiographs showed pubic disjunction with irregular shoreline. CT performed in 2 patients and MRI performed in 2 patients, confirmed the pubic symphysite with an infiltration of the soft parts and soft parts abscess in all cases. A puncture biopsy of the pubic symphysis under CT was performed in all patients. The causative organisms were isolated in 3 cases by biopsy of soft tissue abscess in 2 cases and vaginal swab in one case. Identified germs were staphylococcus aureus Méti-S (n=1), proteus mirabilis (n=1) and varied flora (n=1). The treatment consisted of appropriate antibiotics in all cases and surgical drainage of soft tissue abscess resistant to medical treatment in 2 cases. The outcome was favorable in all cases. <h3>Conclusions</h3> Septic arthritis of the pubic symphysis should be suspected in patients with inflammatory groin pain, pubic pain and fever especially after delivery and pelvic surgery. <h3>Disclosure of Interest</h3> None declared
A wider pathological network underlying breathlessness and respiratory failure in amyotrophic lateral sclerosis
Authors: Kyle T.S. Pattinson, Martin R. Turner
Journal: European Respiratory Journal (2016)

The adult-onset neurodegenerative disorder amyotrophic lateral sclerosis (ALS) is characterised by progressive dysfunction of upper motor neurons of the corticospinal tract, brainstem nuclear and lower motor neurons of the spinal cord anterior horns. There is clinicopathological and genetic overlap with frontotemporal dementia, and an emerging view of ALS as a syndrome [1]. The majority of patients present with either focal limb or bulbar muscle weakness, which then spreads at a variable rate to other body regions [2]. Median survival in ALS is 30 months from symptom onset, with most deaths associated with type II respiratory failure [3]. In the majority of ALS patients, respiratory failure emerges insidiously after a variable period of progressive limb or bulbar muscle weakness. Symptoms are highly variable, but include breathlessness, often with orthopnoea, sleep fragmentation (with nocturnal desaturations detectable on oximetry), daytime somnolence and other systemic symptoms associated with chronic hypercapnia. Neurophysiology studies in ALS may help us better understand breathlessness in primary respiratory disease <http://ow.ly/ZkQLV>
SAT0353 The Relationship Between Patient Satisfaction with Medical Care and Disease Activity in Patients with Systemic Lupus Erythematosus in Republic of Moldova
Authors: M. Cebanu, V. Sadovici, V. Salaru, L. Mazur-Nicorici, M. Mazur
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Interest in patient satisfaction with medical care increased in the last few years and it can be due to numerous factors, including concerns over health care cost, heightened awareness of the influence of psychosocial factors in the process and outcome of medical care [1]. A group of researchers have shown that patient dissatisfaction with health care has been related to patient non-compliance with medical treatment, discontinuation of care and frequent changing of health care providers [2]. We found a few publications related to the satisfaction in patients with systemic lupus erythematosus (SLE), but is not clear how the disease activity is related to the patient satisfaction. <h3>Objectives</h3> To assess the relationship between patient satisfaction with medical care and disease activity among patients with systemic lupus erythematosus. <h3>Methods</h3> Using a cross-sectional design, patients who fulfiled the SLICC classification criteria for SLE were recruited from rheumatology departement. Data collection included demographics, disease duration, phisician-rated indices of disease activity (SLAM), damage (SLICC DI) and patient-completed satisfaction questionaire (PSQ III) [3]. <h3>Results</h3> The study included 106 patients (97 women, 9 mens) with a mean age (±SD) of 41,1±12,6 yr, mean disease duration of 90,0±87,2 months. The disease activity by SLAM was 11±5,17 points and mean SLICC/ACR DI 1,9±2,4 points. Multiple regression analysis revealed that the only determinant for a reduction in general patient satisfaction with medical care was the disease activity by SLAM (r=-0,4, p&lt;0,05). Also, financial aspects of care correlated inversely with higher disease activity and age of patients with SLE (r=-0,4, p&lt;0,05). The other variables included in the regression model seem not to have an impact on satisfaction with medical care. <h3>Conclusions</h3> The disease activity was predictive for patient dissatisfaction with medical care among SLE patients. Higher disease activity and older age were associeted with financial aspect of medical service. <h3>References</h3> Shelbourne CD, Hays RD, Bourton T. Population-based surveys of access and consumer satisfaction with health care. In: Rockville, MD: Agency for Health Care Policy and Research, 1994. Cameron C. Patient compliance: recognition of factors and suggestions for promoting compliance with therapeutic regimens. In: J Adv Nurs, 1996; vol. 24, p. 244-250. Ware, JE, Snyder, MK, Wright, WR. Development and Validation of Scales to Measure Patient Satisfaction with Medical Care Services (1976) Vol I, Part B: Results Regarding Scales Constructed from the Patient Satisfaction Questionnaire and Measures of Other Health Care Perceptions. (NTIS Publication No. PB 288-329). Springfield, VA. National Technical Information Service. <h3>Disclosure of Interest</h3> None declared
Stockings to prevent post-thrombotic syndrome
Authors: Arina J ten Cate-Hoek
Journal: BMJ (2016)

Continuing treatment for two years looks beneficial for those who can

Until recently, the effectiveness of elastic compression stockings for the prevention of post-thrombotic syndrome following deep venous thrombosis (DVT) was considered irrefutable. Compression stockings had been embedded in daily practice and in guidelines,1 2 at least in Europe, since two randomised clinical trials showed that compression reduced the incidence of post-thrombotic syndrome by more than 20%.1 2 The results of the SOX trial, published in 2014, challenged this dogma, suggesting that elastic compression did not prevent post-thrombotic syndrome.3 Although the trial was hampered by a lack of adherence to treatment, treating clinicians readily accepted the negative outcome. Since then, guidelines have been updated and compression stockings devalued and even discouraged.4

In a linked paper (doi:10.1136/bmj.i2691), Mol and colleagues report the results of the OCTAVIA trial, a non-inferiority …