THU0051 The Levels of Serum Pentraxin 3, IL 6, Fetuin A and Insulin in Patients with Rheumatoid Arthritis
Authors: I. Tekeoğlu, A. Kamanlı, S. Sağ, M.S. Sağ, H. Harman, K. Nas, M. Altındiş
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The pathogenesis of RA is not well understood, but genetic, environmental and immunologic factors are known to be involved in the development of the disease. The long pentraxin, pentraxin-3 (PTX-3), is an inflammatory marker and a member of pentraxin superfamily which contains CRP and serum amyloid P. There are some published studies showing the relationship between RA and PTX-3. (1–3). We investigated that PTX3, IL 6, fetuin- A, insulin and HOMA-IR might also have a role in the pathogenesis of RA. <h3>Objectives</h3> The aim of this study was to evaluate the relationship between disease severity and biochemical parameters such as pentraxin-3, fetuin-A, IL-6,insulin and HOMA-IR levels in patients with rheumatoid arthritis. <h3>Methods</h3> This study included 60 patients with RA and 20 healthy controls. Serum pentraxin-3, fetuin-A, IL-6 and insulin concentrations were determined. Also, HOMA-IR values were calculated. Disease activity was assessed with Disease Activity Score (DAS28). Quality of life was evaluated by the use of the Health Assessment Questionnaire disability index. <h3>Results</h3> The serum values for ESR, CRP, pentraxin-3 and fetuin-A in patients with RA were elevated than control subjects (p values=0.001, 0.001, 0.000, 0.000, 0.01, 0.02, respectively) A positive correlation was evident between the DAS 28 score and IL6 levels (r =0.263, p=0.045). We found no correlation between the DAS28 score and HOMA-IR, the levels of pentraxin 3, fetuin A, insulin (p&lt;0.05). Fetuin A levels was positively correlated with cumulative steroid dose (r=0.382, p=0.035). A statistically significant correlation was evident between presence of cardiovascular disease and HOMA-IR values in RA patients (r=0.437, p=0.032). In addition, DAS-28 score values were not in correlation with insulin, fetuin-A, HOMA-IR, IL-6 and pentraxin-3 levels (p&gt;0.05). <h3>Conclusions</h3> Elevated levels of pentraxin-3, fetuin-A, CRP, ESR might play a role in the pathogenesis of RA. Levels of IL-6, fetuin-A, insulin HOMA-IR, pentraxin -3, CRP, ESR concentrations were not associated with clinical severity of the RA. <h3>References</h3> Dessein PH, Norton GR, Woodiwiss AJ, Joffe BI, Solomon A. Independent role of conventional cardiovascular risk factors as predictors of C-reactive protein concentrations in rheumatoid arthritis. J Rheumatol 2007;34:681–8. Hollan I, Nebuloni M, Bottazzi B, Mikkelsen K, Førre OT, Almdahl SM, Mantovani A, Fagerland MW, Aukrust P, Meroni PL; Feiring Heart Biopsy Study Group.Group. Pentraxin 3, a novel cardiovascular biomarker, is expressed in aortic specimens of patients with coronary artery disease with and without rheumatoid arthritis. Cardiovasc Pathol 2013 Sep-Oct;22(5):324–31. Klimek E, Skalska A, Kwaśny-Krochin B, Surdacki A, Sulicka J, Korkosz M, et al. Differential associations of inflammatory and endothelial biomarkers with disease activity in rheumatoid arthritis of short duration. Mediators Inflamm 2014;2014:681635. <h3>Disclosure of Interest</h3> None declared