tbuckley/cabot-search huggingface dataset:
Unexpected High Mortality Rate Due to Acute Respiratory Distress Syndrome Among Infants with AML Enrolled on JPLSG AML-05 Trial
Authors: Daisuke Tomizawa, Akiko Moriya Saito, Takashi Taga, Souichi Adachi, Hideki Nakayama, Hiroshi Moritake, Eiichi Azuma, Akitoshi Kinoshita, Hiroyuki Takahashi, Masue Imaizumi, Kazuko Kudo, Asahito Hama, Masahito Tsurusawa, Keizo Horibe, Akio Tawa
Journal: Blood (2010)
Imatinib Plasma Concentration and Sokal Risk Score Are Independently Prognostic for Complete Cytogenetic Response (CCyR) in Patients with Chronic-Phase Chronic Myeloid Leukemia (CML-CP).
Authors: Richard A. Larson, Brian J. Druker, Francois Guilhot, Stephen G. O’Brien, Tillman Krahnke, Insa Gathmann, Yanfeng Wang
Journal: Blood (2007)
The impact of exposure to particulate air pollution from non-anthropogenic sources on hospital admissions due to pneumonia
Authors: Alina Vodonos, Itai Kloog, Liora Boehm, Victor Novack
Journal: European Respiratory Journal (2016)

Community-acquired pneumonia is a significant cause of morbidity and mortality among older adults [1]. The role of air pollution as a risk factor for pneumonia hospitalisations and mortality has been investigated [2, 3] with most evidence coming from studies in North American and European cities, where anthropogenic sources are predominant in generating air pollution. Natural particulate matter linked to hospitalisation for pneumonia, particularly in older or cardiac patients <http://ow.ly/ct4T303L4QP>
OP0090 Mri Lesions Originating from either Axspa or Degeneration Are Related To Site of Pain in Patients with Chronic Back Pain Included in The Space-Cohort
Authors: M. de Hooge, F. de Bruin, L. de Beer, P. Bakker, R. van den Berg, S. Ramiro, F. van Gaalen, K. Fagerli, R. Landewé, M. van Oosterhout, R. Ramonda, T. Huizinga, J.L. Bloem, M. Reijnierse, D. van der Heijde
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> MRI-lesions in the spine (and SI-joints) are frequent in patients (pts) with axial spondyloarthritis (axSpA) and other pathologies like degenerative disease. It is relevant to know whether MRI-lesions (either axSpA or degenerative changes) are related with the site of back pain. <h3>Objectives</h3> To determine associations between MRI-lesions originating from either axSpA or degeneration and site of pain in pts with chronic back pain (CBP) of ≤2 years. <h3>Methods</h3> Pts with CBP (≥3 months, ≤2 years, onset &lt;45 years) included in the SPACE cohort indicated site(s) of pain (thoracic, lumbar, buttock). Average MRI-scores from two readers for axSpA lesions and from two other readers for degenerative lesions were used. Readers were blinded for clinical data and scores of the other readers. AxSpA lesions considered inflammatory and fatty lesions, erosions and syndesmophytes/ankylosis on MRI-SI and MRI-spine. In addition, sclerosis was scored on MRI-SI. Each vertebral unit was scored for disc degeneration (Pfirrmann class &gt;2), high intensity zone (HIZ), herniation, Schmorls9 nodes and Modic changes (type I and type II). In addition, degenerative disc disease (DDD) was defined as degenerative complex with disc degeneration, an HIZ and herniation in an intervertebral disc. Associations between MRI-SI lesions and buttock pain were investigated by logistic regression. Associations between axSpA or degenerative lesions and pain in the spine (thoracic and lumbar) were investigated by multilevel analysis with generalized estimating equations, taking the level of the spine into account. Interactions with gender, age, HLA-B27 and fulfilment of ASAS axSpA criteria were tested. <h3>Results</h3> In 348 pts (126 males, 127 fulfilling ASAS axSpA criteria, mean age 29.4 years) MRI-spine was available (in 342 pts also MRI-SI). Pain was present in thoracic (35.9%), lumbar (82.5%) spine and/or buttock (57.8%). The figure shows the significant associations between MRI-SI axSpA lesions and pain and between degenerative MRI-spine lesions and pain. AxSpA lesions on MRI-spine were not associated with pain at the same site (data not shown). <h3>Conclusions</h3> Inflammatory axSpA lesions in the SI-joints were associated with buttock pain. Specific degenerative lesions -but not typical axSpA lesions- in the spine were associated with pain at the same location, especially in HLA-B27 negative pts without axSpA and pts ≥35 years. <h3>Disclosure of Interest</h3> None declared
Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance
Authors: Noriyuki Fujikado, Alexander O. Mann, Kushagra Bansal, Kimberly R. Romito, Elise M.N. Ferre, Sergio D. Rosenzweig, Michail S. Lionakis, Christophe Benoist, Diane Mathis
Journal: Immunity (2016)
Iron Overload in Patients with Hematological Disorders Undergoing Allogeneic HSCT: Unrevealed Implication in Different Outcomes
Authors: Mauricette Michallet, Mohamad Sobh, Stéphane Morisset, Hélène Labussière-Wallet, Marie Y. Detrait, Sophie Ducastelle, Fiorenza Barraco, Youcef Chelghoum, Anne Cordonnier, Richard Cohen, Xavier Thomas, Franck E. Nicolini, Colette Chapuis-Cellier
Journal: Blood (2012)
Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement
Authors: P.I. Spuls, L.A.A. Gerbens, E. Simpson, C.J. Apfelbacher, J.R. Chalmers, K.S. Thomas, C.A.C. Prinsen, L.B. von Kobyletzki, J.A. Singh, H.C. Williams, J. Schmitt
Journal: British Journal of Dermatology (2016)

The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, quality of life and long-term control.The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials.Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability and feasibility to be considered for the final COS.At the fourth international HOME meeting, there was broad consensus among all stakeholders that the Patient-Oriented Eczema Measure (POEM) should be used as the core instrument (87·5% agreed, 9·4% unsure, 3·1% disagreed).All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM.
Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption
Authors: Katharine J. Bar, Michael C. Sneller, Linda J. Harrison, J. Shawn Justement, Edgar T. Overton, Mary E. Petrone, D. Brenda Salantes, Catherine A. Seamon, Benjamin Scheinfeld, Richard W. Kwan, Gerald H. Learn, Michael A. Proschan, Edward F. Kreider, Jana Blazkova, Mark Bardsley, Eric W. Refsland, Michael Messer, Katherine E. Clarridge, Nancy B. Tustin, Patrick J. Madden, KaSaundra Oden, Sijy J. O’Dell, Bernadette Jarocki, Andrea R. Shiakolas, Randall L. Tressler, Nicole A. Doria-Rose, Robert T. Bailer, Julie E. Ledgerwood, Edmund V. Capparelli, Rebecca M. Lynch, Barney S. Graham, Susan Moir, Richard A. Koup, John R. Mascola, James A. Hoxie, Anthony S. Fauci, Pablo Tebas, Tae-Wook Chun
Journal: New England Journal of Medicine (2016)

The discovery of potent and broadly neutralizing antibodies (bNAbs) against human immunodeficiency virus (HIV) has made passive immunization a potential strategy for the prevention and treatment of HIV infection. We sought to determine whether passive administration of VRC01, a bNAb targeting the HIV CD4-binding site, can safely prevent or delay plasma viral rebound after the discontinuation of antiretroviral therapy (ART).
Red Cells Release Microparticles Heterogeneous in Phenotypes, Procoagulant Activities, and Size under Different Conditions.
Authors: Wenche Jy, Jaehoon Bang, Joaquin J. Jimenez, Lawrence L. Horstman, Loreta Bidot, James G. White, Carlos J. Bidot, Yeon-Soong Ahn
Journal: Blood (2007)
THU0580 Panniculitis in Rheumatology Practice: Results of Long-Term Follow Up
Authors: N.M. Savushkina, O.N. Egorova, B.S. Belov, S.G. Radenska-Lopovok
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Panniculitis (Pn) is a group of heterogeneous inflammatory diseases characterized by involvement of the subcutaneous fat (SF), musculoskeletal system and internal organs. <h3>Objectives</h3> to evaluate the clinical course and outcomes of Pn in a prospective study. <h3>Methods</h3> 73 pts (F-64, M-9) aged 19 - 77 y., referred for examination and treatment to V.A. Nasonova Research Institute of Rheumatology with referral diagnoses of “erythema nodosum” (EN) and “panniculitis”, disease duration from 1 week to 13 years, were followed up. Patient evaluation included physical examination, lab tests (serum levels of α1-antitrypsin, amylase, lipase, ferritin, creatine phosphokinase (CPK), rheumatoid factor) (RF), ANF, anti-DNA, ANCA), bacteriological and serological tests, radiological examination (chest CT scan), ultrasound examinations of skin and SF around the nodules, tuberculin skin test and histopathology of nodular skin samples. Patients were re-tested during the follow up (FUP) when necessary. The FUP period lasted from 3 to 5 years. <h3>Results</h3> based on clinical, lab and instrumental findings the following diagnoses were verified: EN, associated with infection (22 pts – Group1), lipodermatosclerosis (LDS) (15 pts – Group 2), Weber-Christian9s Pn (11 pts – Group 3), Lőfgren syndrome (25 pts – Group 4). In Group 1 EN recurrences were documented in 10 (45%) pts during the FUP, presumably caused by: common cold (4), exacerbation of chronic tonsillitis (1), acute respiratory viral infection (ARVI) (1), stress (1), rapid down of dose of GCs (1), unknown cause (2). In Group 2 recurrences occurred in 9 (60%) pts due to stress (4), failure to observe anti-inflammatory therapy (hydroxychloroquine) (2), trauma (2), weight lifting (1). There were no recurrences in 3 pts from Group 2, nevertheless they failed to reach complete regression of the nodi, most probably due to poor compliance with treatment. 10 relapses (90,9%) registered in Group 3 were associated with absence/discontinuation of anti-inflammatory therapy (6), insufficient efficacy of administered anti-inflammatory therapy (2), and common cold (2). Relapse of nodules in 6 (24%) pts from Group 4 had the following plausible explanation: common cold /ARVI (5), GCs discontinuation (1). Two (2/7%) death were documented during the FUP: in 1 patient with LDS due to acute heart failure, and in 1 patient with Weber- Christian disease due to chronic cardio-pulmonary failure. <h3>Conclusions</h3> common cold and viral infections were the leading causes of relapses in pts with EN associated with infection and with Lőfgren syndrome, while stress and absence/insufficient efficacy of anti-inflammatory therapy were the major causes of recurrence in pts with Weber-Christian Pn and LDS. In this Pn case series mortality was 2,7% during the FUP. <h3>Disclosure of Interest</h3> None declared
Platelets Mediate Cytotoxic T Lymphocyte-Induced Liver Damage.
Authors: Matteo Iannacone, Giovanni Sitia, Masanori Isogawa, Patrizia Marchese, Maria G. Castro, Pedro L. Lowenstein, Francis V. Chisari, Zaverio M. Ruggeri, Luca G. Guidotti
Journal: Blood (2005)
Abstract 2326: Sox10 promotes both stem-like and EMT properties in mammary cells
Authors: Christopher Dravis, Geoffrey M. Wahl
Journal: Cancer Research (2015)

Abstract Molecular pathways that guide cell proliferation and programming events during embryonic development may be aberrantly re-activated in the cancer state to drive tumor progression. To identify mechanisms that drive progression of aggressive breast cancers, we identified molecules that are present in the fetal mammary stem cells (fMaSCs) that drive early development of the mammary gland. These analyses revealed that Sox10 is one of the most highly expressed transcription factors within fMaSCs, and prompted us to investigate the function of Sox10 in the mammary gland and in subtypes of cancer originating from it. Our studies described here indicate that Sox10 is specifically expressed in mammary cells that exhibit higher levels of stem or progenitor cell functions using in vitro or in vivo assays. This includes fetal and adult mammary cells in vivo, as well as mammary cells cultured in vitro as organoids, and for the first time, male fetal mammary stem cells. Sox10 appears to contribute to these stem/progenitor behaviors, as the genetic deletion of Sox10 limits stem/progenitor activities, while the overexpression of Sox10 significantly expands clonogenic behavior. Intriguingly, ectopic Sox10 expression is also able to elicit an EMT-like response in mammary organoids. Sox10 thus represents a single molecule capable of directly mediating both stem-like and EMT-like properties in mammary cells. Furthermore, by modulating Sox10 levels in 3D mammary organoids, we are able to induce cells into sequential motile and stem/progenitor states. This provides a striking in vitro surrogate for metastatic behavior. Consistent with these findings, we find that Sox10 is highly expressed in basal-like and claudin-low subtypes of breast cancer, which are the most stem-like and EMT-like manifestations of the disease, respectively. Finally, we show that Sox10 expression is regulated through a feedback loop involving FGF signaling, and that inhibition of FGF signaling can block EMT-like cell behaviors mediated by Sox10. These findings have important implications in how stem-like and metastatic properties may be specified in mammary cells. Citation Format: Christopher Dravis, Geoffrey M. Wahl. Sox10 promotes both stem-like and EMT properties in mammary cells. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2326. doi:10.1158/1538-7445.AM2015-2326
OC-083 Previous gynaecological surgery has no effect on symptom resolution and quality of life following laparoscopic ventral mesh rectopexy: Abstract OC-083 Table 1
Authors: T Roe, A Dixon
Journal: Gut (2015)

<h3>Introduction</h3> Laparoscopic ventral mesh rectopexy (LVMR) is becoming ever more widely used in the management of rectal prolapse, intussusception and obstructive defecation syndrome (ODS). It is widely accepted that previous gynaecological surgery, and hysterectomy in particular, predispose women to developing pelvic floor dysfunction. It is unclear whether such interventions have any impact on the efficacy of LVMR in terms of symptom resolution or quality of life. We aimed to investigate whether there is any negative effect on quality of life post-LVMR that is attributable to gynaecological surgical history. <h3>Method</h3> We investigated a prospectively collected database maintained by a single pelvic floor surgeon with expertise in LVMR. We compared women with a history of gynaecological surgery against those who had never undergone any form of abdominal or pelvic operative procedure. Data were collected on patient demographics, surgical history, intra-operative details, and quality of life (QoL) and bowel function. This included pre- and post-operative ODS scoring. QoL was assessed via the validated Birmingham Bowel and Urinary Symptoms Questionnaire-22 (BBUSQ-22) and was collected up to a maximum of 8 years after LVMR. <h3>Results</h3> From a database of over 1000 LVMR patients there were 439 women who had previously undergone gynaecological surgery and 271 with no abdominal or pelvic surgical history of any sort. Median age in the gynaecology surgery group (GS) was 53 (IQR 43–65) and 63 (54–72) in the non-surgical group (NS). Mean pre-op ODS scores were 19.6 (NS) and 19.3 (GS) and fell to 8.1 and 8.5 respectively. These figures represent percentage improvements of 59% and 56%. The trend in QoL score pre-LVMR and through 8 years of follow-up is shown in the Table 1: At 8 years there was a 40% QoL improvement in the NS group and a 39% improvement in the GS group. There were no statistically significant differences in function or QoL score between the groups at any point during the study. <h3>Conclusion</h3> LVMR is equally efficacious in treating a range of pelvic floor pathology in patients who have previously undergone gynaecological surgery compared to women who have no history of abdominal or pelvic surgical procedures. Sustained functional and QoL benefits are seen post-operatively in both groups with no statistical difference in percentage improvement. <h3>Disclosure of interest</h3> None Declared.
Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4
Authors: Mark W. Majesky, Henrick Horita, Allison Ostriker, Sizhao Lu, Jenna N. Regan, Ashim Bagchi, Xiu Rong Dong, Joanna Poczobutt, Raphael A. Nemenoff, Mary C.M. Weiser-Evans
Journal: Circulation Research (2016)

Rationale: The vascular adventitia is a complex layer of the vessel wall consisting of vasa vasorum microvessels, nerves, fibroblasts, immune cells, and resident progenitor cells. Adventitial progenitors express the stem cell markers, Sca1 and CD34 (adventitial sca1-positive progenitor cells [AdvSca1]), have the potential to differentiate in vitro into multiple lineages, and potentially contribute to intimal lesions in vivo. Objective: Although emerging data support the existence of AdvSca1 cells, the goal of this study was to determine their origin, degree of multipotency and heterogeneity, and contribution to vessel remodeling. Methods and Results: Using 2 in vivo fate-mapping approaches combined with a smooth muscle cell (SMC) epigenetic lineage mark, we report that a subpopulation of AdvSca1 cells is generated in situ from differentiated SMCs. Our data establish that the vascular adventitia contains phenotypically distinct subpopulations of progenitor cells expressing SMC, myeloid, and hematopoietic progenitor-like properties and that differentiated SMCs are a source to varying degrees of each subpopulation. SMC-derived AdvSca1 cells exhibit a multipotent phenotype capable of differentiating in vivo into mature SMCs, resident macrophages, and endothelial-like cells. After vascular injury, SMC-derived AdvSca1 cells expand in number and are major contributors to adventitial remodeling. Induction of the transcription factor Klf4 in differentiated SMCs is essential for SMC reprogramming in vivo, whereas in vitro approaches demonstrate that Klf4 is essential for the maintenance of the AdvSca1 progenitor phenotype. Conclusions: We propose that generation of resident vascular progenitor cells from differentiated SMCs is a normal physiological process that contributes to the vascular stem cell pool and plays important roles in arterial homeostasis and disease.
Late Pulmonary Dysfunction in Long-Term Survivors after allogeneic Hematopoietic Stem Cell Transplantation with Intensified Conditioning Regimen Including Thiotepa, Cyclophosphamide, and Total Body Irradiation.
Authors: Satomi Ito, Maki Hagihara, Kenji Motohashi, Atsuo Maruta, Yoshiaki Ishigatsubo, Heiwa Kanamori
Journal: Blood (2008)
A patient with head and neck swelling
Authors: Sarah Hancox, David Howlett
Journal: BMJ (2016)

A 50 year old man presented to the emergency department with swelling and venous engorgement of his face, arms, and upper chest. He also had increasing shortness of breath. Chest radiography showed mediastinal widening. What does the computed tomography (CT) scan show (fig 1⇓)?



Fig 1 …
Hepatitis-C-virus-induced microRNAs dampen interferon-mediated antiviral signaling
Authors: Abigail Jarret, Adelle P McFarland, Stacy M Horner, Alison Kell, Johannes Schwerk, MeeAe Hong, Samantha Badil, Rochelle C Joslyn, Darren P Baker, Mary Carrington, Curt H Hagedorn, Michael Gale, Ram Savan
Journal: Nature Medicine (2016)
FRI0250 Self Reported Gastrointestinal Tract Symptoms in Systemic Sclerosis: Experience from A Large Consecutive Cohort
Authors: T. Garen, H. Andersson, Ø. Midtvedt, A.M. Hoffmann Vold, Ø. Palm, Ø. Molberg
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Gastrointestinal tract (GIT) involvement in systemic sclerosis (SSc) is common, occurring in 50–90% of the patients (1). However, there is limited knowledge of self reported GIT symptoms affecting patients in daily life. <h3>Objectives</h3> To describe frequency and severity of self reported gastrointestinal symptoms in a large SSc cohort and evaluate possible correlations between special clinical characteristics and GIT-symptoms. <h3>Methods</h3> Patients from the The Norwegian Systemic Connective Tissue Disease and Vasculitis Registry (NOSVAR) who fulfilled the 2013 ACR/EULAR SSc criteria were included (N=245)). The patients completed the UCLA SCTC GIT 2.0 questionnaire which comprises seven clinical symptoms; Reflux, distention/bloating, diarrhea, fecal soilage, social functioning, emotional well-being and constipation. All variables are scored from better to worse in health related quality of life (HRQL) with a mean total score of 2.8. In addition we used the visual analogue scale on intestinal problems (VAS-GIT) of the Scleroderma Health Assessment Questionnaire (SHAQ) with a maximum score of 3. Disease duration was defined as time from diagnosis to the completion of the questionnaires. Possible correlations were tested by Spearman9s correlation coefficient. <h3>Results</h3> Patient characteristics and frequencies of the different GIT symptoms are presented in Table 1. Distention bloating, reflux and diarrhea were the most frequent symptoms reported (80%, 69% and 61%, respectively. The least reported symptom was fecal soilage (16%) (Figure 1). Mean (SD) total GIT score was 0.42 (0.41), indicating mild symptoms. The seven subscales ranged from mean (SD) 0.22 (0.55) for fecal soilage to mean (SD) 0.95 (0.50) for distention/bloating. Mean (SD) VAS-GIT score was 0.33 (0.37) and correlated strongly with the mean total UCLA-GIT score (0.667, p&lt;0.001). Female sex and disease duration correlated weakly with mean total UCLA-GIT score (r=-.234, r=199, respectively), as did positive anticentromere-antibody (r=.229).No correlation was found between mean total UCLA-GIT score and subset of SSc, interstitial lung disease, pulmonary hypertension, digital ulcers, Rodnan skin score or Raynaud. <h3>Conclusions</h3> This study describes a high frequency of self-reported gastrointestinal symptoms in systemic sclerosis patients classified as mild to moderate symtoms. Positive anticentromere-antibody, disease duration and female sex had a minor impact on mean total UCLA-GIT score. The correlation between mean total UCLA-GIT score and the VAS-GIT score of the SHAQ was highly significant indicating a good conformity between the tests. <h3>References</h3> Forbes A, Marie I: Gastrointestinal complications: the most frequent internal complications of systemic sclerosis. Rheumatology (Oxford) 2009;48 Suppl 3:36–9. <h3>Disclosure of Interest</h3> None declared