tbuckley/cabot-search huggingface dataset:
Abstract 982: Increasing HPV vaccine utilization among Hispanic girls to reduce cervical cancer disparities
Authors: Pamela C. Hull, Maureen Sanderson, Dineo Khabele, Juan Canedo
Journal: Cancer Research (2010)

Abstract Incidence and mortality rates from cervical cancer are higher in Hispanic women compared to non-Hispanic white women. The purpose of this pilot study is to implement and assess a multilevel, culturally- and linguistically-appropriate social marketing intervention targeting the Hispanic population to increase utilization of the HPV vaccine among Hispanic girls ages 9-18 in Nashville/Davidson County, Tennessee. The specific aims are to (1) pre-test and disseminate culturally- and linguistically-appropriate media messages to promote use of the HPV vaccine in the target population; (2) provide information, referral and follow-up reminders to families to encourage initiation and completion of HPV vaccine series; and (3) assess the impact of the intervention by comparing changes in HPV vaccine utilization rates for Hispanic girls in partner clinics and in the state Immunization Registry. This pilot translational research study draws on Rogers’ Diffusion of Innovation theory. We employ the methodology of Community-Based Prevention Marketing, which combines social marketing theories and techniques with community-based participatory research (CBPR) approaches. The intervention uses a combination of Spanish-language media_radio, newspaper and printed brochures_to disseminate the messages throughout the community. A trained lay health promoter (promotora de salud) at Progreso Community Center receives phone calls to answer general questions about the vaccine and eligibility requirements for the VFC program, refers patients to appropriate locations to obtain the vaccine, and provides follow-up reminders. In this presentation we will present how formative research findings were used to develop the intervention and preliminary baseline intervention data. Targeted interventions to Hispanic communities such as this one to encourage use of a new cervical cancer vaccine could help eradicate ethnic disparities in cervical cancer. The study contributes valuable knowledge to the dearth of research on possible barriers for Hispanics to use this vaccine or about culturally- and linguistically-appropriate social marketing strategies for HPV vaccine use among Hispanics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 982.
AB0085 Murine antigen-induced arthritis is not affected by transgenic disruption of osteoblastic glucocorticoid signaling
Authors: C. M. Spies, E. Wiebe, J. W. Tu, T. Gaber, D. Huscher, M. Seibel, H. Zhou, F. Buttgereit
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The role of endogenous glucocorticoids (GC) in the initiation and maintenance of rheumatoid arthritis (RA) remains unclear. We demonstrated previously that disruption of GC signaling in osteoblasts results in a profound attenuation of arthritis in the K/BxN serum-induced mouse model of RA (1). <h3>Objectives</h3> To determine whether or not the modulation of the inflammatory response by osteoblasts involves T cells, we studied the effects of disrupted osteoblastic GC-signaling in the T cell-dependentmodel of antigen-induced arthritis (AIA). <h3>Methods</h3> GC signaling in osteoblasts was disrupted by transgenic overexpression of 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) under the control of a type I collagen promoter. Acute arthritis was induced in pre-immunized 11-week-old male transgenic (tg) mice and their wild-type (WT) litter-mates by intra-articular injection of mBSA into one knee joint. Knee diameter was measured every 1-2 days until euthanasia on day 14 post injection. In a separate experiment, arthritis was maintained for 28 days by weekly intravenous reinjections of mBSA. Tissues were analyzed by histology, histomorphometry and microfocal-computed tomography. Serum cytokines levels were determined by multiplex suspension array. <h3>Results</h3> In both short and long term experiments, arthritis developed in tg and WT mice with no significant difference between both groups. Histological indices of inflammation, cartilage damage and bone erosion were similar in tg and WT mice. Bone volume and turnover at the contralateral tibia and systemic cytokine levels remained unchanged. <h3>Conclusions</h3> In contrast to K/BxN serum-induced arthritis, murine AIA is not affected by a disruption in osteoblastic GC signaling. These data indicate that osteoblasts do not modulate the T cell-mediated, but rather the immune complex-mediated inflammatory response via a GC-dependent pathway. <h3>References</h3> Buttgereit et al. Arthritis Rheum 2009. <h3>Acknowledgements</h3> This work was supported by a grant from the German Research Foundation (DFG) in association with the Priority Program SPP 1468 "Osteoimmunology IMMUNOBONE – A Program to Unravel the Mutual Interactions between the Immune System and Bone" and by the National Health &amp; Medical Research Council, Australia. <h3>Disclosure of Interest</h3> None Declared
SISTEMA ABIERTO DE SOLICITUD DE COLONOSCOPIA DESDE ATENCIÓN PRIMARIA
Authors: MA Martinez Menendez, E Barbón Remis, J Perez Fernández, E Cuesta Fernández, ME Mata Peon, S Bermudez Fernández, I Mañana Canteli
Journal: Endoscopy (2014)

Introducción: En España el cáncer de colon es el segundo tumor que más muertes causa. La colonoscopia, con visualización de la mucosa y la extirpación de pólipos, puede prevenir el cáncer colorrectal.
The Timing of Prophylactic Administration of Antibiotics and the Risk of Surgical-Wound Infection
Authors: D C Classen, R S Evans, S L Pestotnik, S D Horn, R L Menlove, J P Burke
Journal: New England Journal of Medicine (1992)

Randomized, controlled trials have shown that prophylactic antibiotics are effective in preventing surgical-wound infections. However, it is uncertain how the timing of antibiotic administration affects the risk of surgical-wound infection in actual clinical practice.
Carotid–Cavernous Sinus Fistula
Authors: Bobby S Korn, Kang Zhang
Journal: New England Journal of Medicine (2011)

A 55-year-old woman with a long history of hypertension presented to the hospital with a 1-day history of periorbital discomfort, inferior chemosis, and conjunctival injection of the left eye (Panel A). She reported having a 2-year history of episodic headache and pulsatile tinnitus in the left ear. Examination of the left eye revealed a visual acuity of 20/60, a relative afferent pupillary defect, exophthalmos (with 6 mm of protrusion), and an elevated intraocular pressure (48 mm Hg). Examination of the right eye was unremarkable. Contrast-enhanced computed tomography of the orbit showed a dilated left superior ophthalmic vein (Panel B, arrow), . . .
P1311 REDUCED HEPATIC INJURY IN BOTH IL1α AND IL1β DEFICIENT MICE FOLLOWING D-GALACTOSAMINE/LIPOPOLYSACCHARIDE-INDUCED FULMINANT HEPATIC FAILURE
Authors: M. Sultan, M. Safran, E. Lahat, D. Harats, Y. Kamari, Z. Ben-Ari
Journal: Journal of Hepatology (2014)
PTU-088 Variation in Practice of Management of Spontaneous Bacterial Peritonitis (SBP)
Authors: A Sugumaran, C Ch’ng
Journal: Gut (2013)

<h3>Introduction</h3> Spontaneous Bacterial Peritonitis (SBP) is the most frequent and life-threatening infection in patients with liver cirrhosis, requiring prompt recognition and treatment. Clinical practise guidelines on management of SBP were released by EASL in 2010<sup>1</sup> and AASLD in 2009<sup>2</sup>. We wanted to determine if there is uniformity in SBP management in hospitals in Wales, UK. <h3>Methods</h3> Invitation to online survey was sent via email link to all WAGE members (Welsh Association for Gastroenterologists and Endoscopists). 25 members responded and results analysed. There were total of 10 questions with focus on diagnosis and drug treatment. <h3>Results</h3> 76% of respondents would test for SBP in any cirrhotic ascites including day case routine admissions for therapeutic paracentesis; 12% do not test for day-case asymptomatic patients. 12% test only if presence of sepsis and 4% only if patients are encephalopathic. Only 28% have access to lab polymorphonuclear leucocytes in ascites to confirm SBP; 60% use White Cell Count (WCC) &gt; 250 and 16% use WCC &gt; 500 in ascitic fluid as criteria. Cefotaxime (52%) and Tazocin (32%) were the preferred antibiotic choices with treatment duration ranging between &lt; 5 days (4%), 5–7 days (40%) and &gt; 7 days (56%). Surprisingly, 8 out of 22 respondents (36.3%) do not administer albumin routinely for confirmed SBP but 100% prefer 20% human albumin compared to 4.5% human albumin. There was huge discrepancy in the albumin administration regime between the members. One Consultant gives Terlipressin to all SBP but 24% will consider terlipressin if patients are at high risk of hepatorenal syndrome. 4% routinely repeat diagnostic ascitic tap after 48 hours on SBP treatment while 20% repeat only if infection not settling; 64% do occasionally and 12% ‘never’ repeat. A good 16.7% members do not start prophylactic antibiotics after an episode of SBP but with others, Ciprofloxacin (50%) and Norfloxacin (30%) are favourites. 96% are not in favour of primary antibiotic prophylaxis for ascites with low protein counts. Encouragingly, 45.8% would consider referral for liver transplantation in appropriate patients after an episode of SBP. <h3>Conclusion</h3> Even among specialists dealing with chronic liver disease patients day to day, there is wide variation in management of SBP. It is alarming to note that doctors do not believe in secondary prophylaxis and do not administer albumin as part of treatment. There is serious need to standardise treatment and prevent improper management that can cause deterioration in liver function rendering them poor candidates for transplantation. <h3>Disclosure of Interest</h3> None Declared <h3>References</h3> EASL clinical practise guidelines on the management of ascites, spontaneous bacterial peritonitis and hepatorenal syndrome in cirrhosis. Journal of hepatology 2010 Vol53:397–417 Runyon BA. Management of adult patients with ascites due to cirrhosis: an update. Hepatology 2009; 49:2087–107
SAT0315 Comparison of the euroqol and short form 6D in multiethnic asian patients with psoriatic arthritis:
Authors: Y.Y. Leung, M.E. Png, H.L. Wee, J. Thumboo
Journal: Annals of the Rheumatic Diseases (2013)

Objectives To compare EuroQol (EQ-5D) and Short form 6D (SF-6D) utility scores among multiethnic Asian patients with psoriatic arthritis (PsA). Methods Consecutive patients fulfilling the Classification Criteria for Psoriatic Arthritis (CASPAR) for PsA and attending a tertiary rheumatology outpatient clinic were invited to complete identical English or Chinese questionnaires of EQ-5D and SF-6D and assessing socio-demographic characteristics. Utility scores were calculated using the scoring algorithms developed from the UK general population. Comparisons between the 2 instruments were performed by their score distributions, means, medians, intraclass correlation coefficients (ICCs) and Bland-Altman plot. Results Subjects (n=86, 69 English and 16 Chinese speaking, male to female ratio 0.91) participated. Mean age (±SD) and duration of illness (±SD) were 49.1 (±13.4) and 7.1 (±8.2) years. The score distribution for SF-6D was normal while that of EQ-5D was bimodal. Ceiling and floor effects were observed in 2.3% and 20% for EQ-5D and none for SF-6D. Moderate correlations are demonstrated between the 2 scores on scale level (range 0.44-0.59) and domain level (range 0.33-0.53). The mean (±SD) EQ-5D and SF-6D utility scores were 0.74 (±0.24), [range -0.16-1.00] and 0.68 (±0.13), [range 0.36-1.00]; (p=0.001). Every 10-point increase in EQ-5D health state VAS was associated with a 0.07 and 0.04 quality-adjusted life year (QALY) gain if using EQ-5D and SF-6D respectively. EQ-5D generated higher utility scores than SF6D in subgroup with better health, and the opposite occurred in less healthy subgroup. Poor agreements between EQ-5D and SF-6D utility scores were demonstrated with the low ICC (0.43) and the Bland-Altman plot. View this table: Table 1. Comparison of EQ-5D and SF-6D utility scores for patients and subgroups Conclusions Using different preference-based health-related quality of life instruments yield different utility scores, which may have a great impact on QALY estimates. This highlights the importance of choosing the appropriate instrument for cost-effectiveness evaluation. Additional research is needed to determine if EQ-5D or SF-6D is the better instrument for PsA. Disclosure of Interest None Declared
Abstract 4315: A novel role for the high affinity IL13 receptor in glioblastoma multiforme
Authors: Melanie S. Prasol, Kyung-Sub Moon, Maciej S. Lesniak, Irina V. Balyasnikova
Journal: Cancer Research (2012)

Abstract IL13 Receptor alpha 2 (IL13Ra2) is one of two receptors for IL13 and is found to be highly expressed in a number of cancers including, ovarian, head and neck, pancreatic and glioblastoma multiforme (GBM). IL13Ra2 has been found to be expressed mostly in high grade GBMs but not in low grade gliomas or normal brain tissue. IL13Ra2 has a short intracellular domain that lacks a signaling domain and possesses a high affinity for IL13. It is thought that in GBMs IL13Ra2 acts primarily as a decoy receptor for IL13. However, recent evidence from pancreatic and ovarian cancer lines indicates that IL13Ra2 initiates signaling pathways that influence cell invasion and adhesion properties of cancer cells. We hypothesize the IL13Ra2 might play a role in GBMs distinct for its decoy receptor function. This study is designed to determine if IL13Ra2 possess functional properties and can modulate the behavior of glioma cells through its interaction with IL13. We examined the effect of IL13 interaction with IL13Ra2 in multiple glioma cell lines in vitro. A BrdU based proliferation assay was utilized to determine the effect of IL13 on the proliferation rate of glioma cells. Migration of glioma cells was also examined over a 24 hour period following exposure to IL13. A shRNA mediated knockdown of IL13Ra2 in glioma cells was also produced and the resultant phenotype analyzed by phalloidin staining for cytoskeletal actin and in the migration assay. Treatment of IL13Ra2 expressing glioma cell lines with IL13 did not influence their proliferation rates in vitro. However, cells that had been treated with IL13 demonstrated an increased migration response. Knockdowns were found to have decreased migration rates, both in the presence and absence of IL13. Knockdowns were also found to have dramatic changes in phenotype with increased cellular adhesion and altered actin structure. When the actin structure was examined following IL13 treatment, normal cells appeared to have an increase in peripheral actin and filopodia, while in knockdown cells treated cells did not appear different from untreated controls. Our data indicate that IL13 interaction with IL13Ra2 might contribute to changes in the phenotype of glioma cells that promote their invasive properties. Further research is needed to determine the underlying mechanism. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4315. doi:1538-7445.AM2012-4315
A phase I-II trial of <i>Ispinesib</i>, a kinesin spindle protein inhibitor, dosed every two weeks in patients with locally advanced or metastatic breast cancer previously untreated with chemotherapy for metastatic disease or recurrence.
Authors: H Gomez, C Castaneda, M Philco, P Pimentel, S Falcon, R Escandon, K Saikali, M Conlan, J Seroogy, A Wolff
Journal: Cancer Research (2009)

Abstract Abstract #2148 Kinesin Spindle Protein (KSP) is a mitotic kinesin essential for cell cycle progression. Ispinesib, a selective KSP inhibitor, blocks mitotic spindle assembly with cell cycle arrest in mitosis and subsequent cell death. When dosed on a q21d schedule, the maximum tolerated dose (MTD) was 18mg/m2 and neutropenia was the dose-limiting toxicity (DLT), with nadir at 7-10 d and recovery by d15. Activity was observed in a Phase II trial of ispinesib dosed at 18 mg/m2 q21d in patients (pts) with locally-advanced (LA) or metastatic breast cancer (MBC) after anthracycline and taxane failure (response rate 4/45 [9%]). This trial evaluates safety and efficacy of ispinesib in LA or MBC, given on d1 and d15 q28d, thus increasing dose density.&amp;#x2028; Methods: This is a multicenter Phase I-II trial. In Phase I, DLT and MTD of ispinesib given d1 and d15 q28d will be determined. Eligibility criteria: LA or MBC; no prior chemotherapy (CT) except neoadjuvant or adjuvant and ≥ 1 year elapsed since CT; no CNS or leptomeningeal metastases; ECOG 0-1. This is a standard 3+3 dose escalation trial design, starting at 10 mg/m2 and escalating based on tolerability in Cycle 1. Pharmacokinetic data are collected on d1 and d15 of Cycle 1. Phase II of this trial will evaluate efficacy (response rate by RECIST) of ispinesib at the MTD.&amp;#x2028; Results: Phase I of the trial is ongoing. To date, 13 pts have been treated at 3 dose levels: 10 (n=2; 2 cycles, n=1; 6 cycles), 12 (n=1; 1 cycle, n=2; 3 cycles) and 14 mg/m2 (n=7; Cycle 1 ongoing). Among the first 6 pts, 4 were Stage IV, 3 had prior neoadjuvant and 2 adjuvant CT; 2 were chemo-naïve. Four had prior anthracycline and 3 prior taxane. Biomarker status was ER+, PR+, HER2- (n=3), ER+, PR-, HER2- (n=1), ER-, PR-, HER2+ (n=3), ER-, PR-, HER2- (n=4), and unknown (n=2). Mean age was 55 yr; for the first 2 dose levels (n=6 pts), the most frequent toxicity was neutropenia (n=4). Other events included mild GI toxicity. No neuropathy or alopecia has been reported. The only grade 3 or 4 toxicity was neutropenia (n=2). At the 14 mg/m2 dose level, one DLT has been reported: a grade 3 transaminase (AST) elevation in a patient with liver metastases which resolved with a dose delay of 4 days. As a result, this cohort was expanded to include 6 evaluable pts. One additional patient at the 14mg/m2 dose had a dose delay of 5 days due to non-DLT neutropenia.&amp;#x2028; Conclusions: Ispinesib appears to be well tolerated on a q2w dosing schedule at doses tested to date. A dose-density equal to that administered in the prior Phase II trial (0.86 mg/m2/day) was tolerated with the new q2w schedule. Dose escalation is ongoing. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 2148.
Abstract 1473: Fra-2 and JunB are overexpressed in precancerous bile ducts and primary/transplanted hamster cholangiocarcinomas with a strong positive correlation
Authors: Byung-Suk Jeon, Byung-Woo Lee, Byung-Il Yoon
Journal: Cancer Research (2010)

Abstract The transciption factor complex AP-1 plays important roles in cell proliferation, differentiation and apoptosis of which dysregulation is closely associated with cancer development. Fra-2 and JunB, components of AP-1 family proteins, had been found overexpressed in certain of tumors, suggesting their possible implication in carcinogenesis. In the present study, we investigated differential expression patterns of those two AP-1family proteins during hamster cholangiocarcinogenesis and aggressive transplanted cholangiocarcinomas (ChCs). First, we prepared appropriate liver tissue samples with precancerous lesions and ChCs from hamster ChC model as well as normal liver. The transplanted ChCs were produced by syngenic transplantation of the primary ChCs. We then performed immunohistochemistry (IHC) for Fra-2 and JunB using ABC methods. The typical nuclear staining for Fra-2 and JunB was determined as positive immunoreactivity and the ratio of positive cells was evaluated by counting 800-3000 cells, followed by statistical analysis. The correlation of Fra-2 and JunB expression was analyzed by scattergram. Our IHC indicated significantly increased frequency of Fra-2 and JunB positive cells according to the tumor progression, i.e., respectively in the early dysplatic bile ducts (10∼20%) and late dysplastic bile ducts (40∼50%), primary ChC (40∼60%) and transplanted ChC (higher than 70% positivity), while normal and simple hyperplastic bile duct epithelia were negative or indicated very low labeling index for both Fra-2 and JunB (under 1% positivity). The expression of Fra-2 and JunB showed a strong correlation (r=0.93) and the immunoreactive cells for Fra-2 and JunB were mainly localized in the invading areas adjacent to normal surrounding tissue. In summary, we found in the present study the followings 1) Expression of Fra-2 and JunB progressively increased as bile duct cells become carcinogenic, 2) Fra-2 and JunB have a high correlation in the expression patterns in the biliary cell populations including cancers, 3) In the transplanted biliary cancers, overexpression of Fra-2 and JunB (especially JunB) were localized in the neoplastic cells which are very aggressive to invade into adjacent normal tissue. Based on our results, Fra-2 and JunB could play significant roles in cholangiocarcinogenesis, possibly by collaboratively participating in dysplastic changes and acquisition of tumorigenicity of candidate bile duct cells for ChC. Also, those two AP-1 family proteins could contribute to invasiveness of biliary cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1473.
Perioperative Acute Kidney Injury
Authors: Macaulay Amechi Chukwukadibia Onuigbo
Journal: JAMA Surgery (2016)

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