tbuckley/cabot-search huggingface dataset:
CD166 (ALCAM): A Functional Marker of Primitive Murine and Human Hematopoietic Stem Cells and Cellular Elements of Their Niche
Authors: Brahmananda Reddy Chitteti, MIchihiro Kobayashi, Yinghua Cheng, Peirong Hu, Bradley Poteat, Hal E. Broxmeyer, Louis M. Pelus, Melissa A. Kacena, Edward F. Srour
Journal: Blood (2012)
Improved Outcome Following Reduced Intensity Allogeneic Transplantation in Hodgkin’s Lymphoma Relapsing Post-Autologous Transplantation.
Authors: Kirsty J. Thomson, Karl S. Peggs, Paul Smith, Raj Chopra, Jim Cavet, Ann Hunter, Anne Parker, Ruth Pettengell, Don Milligan, Emma C. Morris, Anthony H. Goldstone, David C. Linch, Stephen Mackinnon
Journal: Blood (2005)
Biceps femoris architecture: the association with injury and response to training
Authors: Ryan Timmins
Journal: British Journal of Sports Medicine (2016)

First I looked to see if two-dimensional ultrasound could show us anything new in the battle against hamstring strain injuries (HSI), mainly in those with a history of injury, but also seeing if biceps femoris long head (BFlh) architecture alters future injury risk. I then implemented a resistance training programme to see if we can change these characteristics which increased the risk of HSI.

In a number of sports, HSIs are consistently the most common, non-contact injury with a high risk for recurrence.1 ,4 This suggests we still do not fully understand the aetiology of hamstring injury and re-injury. Non-modifiable risk factors (eg, increasing age and a previous injury history) have been shown to increase HSI risk; yet there are still a number of potentially modifiable risk factors that are …
In Chronic Myeloid Leukemia Cytotoxic T Cell Responses to BMI-1 Protein Correlate with Higher Expression of BMI-1 in Leukemia Progenitors, and May Contribute to Improved Outcome After Allogeneic Stem Cell Transplantation.
Authors: S. M. Agnes Yong, Nicole Stephens, Bipin N. Savani, Yixin Li, Rhoda Eniafe, Keyvan Keyvanfar, Roger J Kurlander, Katayoun Rezvani, A. John Barrett
Journal: Blood (2009)
Experience of a Brazilian Institution with Adult Acute Lymphoblastic Leukemia: Clinical, Laboratory and Prognosis in 102 Patients.
Authors: Edilson D. Pinheiro-júnior, Elvira R.P. Velloso, Beatriz Beitler, Gracia A. Martinez, Monika Conchon, Pedro E. Dorlhiac-LLaccer, Luiz F. Pracchia, Dalton A.F. Chamone
Journal: Blood (2006)
Abstract 19240: Operative Indication for Chronic Dissecting Aneurysm in Descending Thoracic and Thoracoabdominal Aorta
Authors: TATSUYA ODA, Kenji Minatoya, Hiroaki Sasaki, Hiroshi Tanaka, Yoshimasa Seike, Tatsuya Itonaga, Yosuke Inoue, Junjiro Kobayashi
Journal: Circulation (2015)

Background: Because of a lack of information about the rupture size of chronic dissecting descending thoracic and thoracoabdominal aneurysms, we evaluated the natural history of those aneurysms. Patiens and Methods: Data on 422 patients (mean age, 63.3 ± 11.3; 272 male) with chronic dissection in descending thoracic and thoracoabdominal aorta treated at our institution from 2007 to 2014, were analyzed. Patients with connective tissue disorder, impending rupture of aneurysms, infected aneurysms, and an acute dissection without aneurysms were excluded. Chronic dissection was defined as a dissection more than 2 weeks from symptom onset. The aneurysm diameter at the time of the rupture was measured on CT scan in ruptured aneurysms group (n=21), and initial aneurysmal diameter on CT scan in non-ruptured aneurysms group (n=401). The measurements were performed at maximum short axis diameter of the aneurysm on three-dimensional CT. Results: Midian size of all aneurysms was 4.5 cm (range 3.5 to 9.0 cm) and that of in ruptured aneurysms was 5.9 cm (range 4.5-8.0 cm). The location of aneurysms was descending aorta in 303 patients, thoracoabdominal aorta in 119. Aortic surgery was performed in 150 patients (urgent in 20, elective in 130). Hospital mortality rate were 20% (5/20) in patients with ruptured aneurysms and 2.3% (3/130) in patients with non-ruptured aneurysms. Figure shows the incidences of rupture according to the aneurysm size. The incidence of a rupture increases with larger aortic size. At 3.5 to 3.9 cm, 4.0 to 4.4 cm, 4.5 to 4.9 cm, 5.0 to 5.4 cm, 5.5 to 5.9 cm and more than 6.0 cm, the incidence of rupture was 0%, 0%, 1.2%, 10.2%, 14.3% 20.8%, respectively. The aneurysms more than 5.0 cm were ruptured in 15.1% of patients. Conclusions: Because an elective operation is associated with low mortality, operative indication of chronic dissecting aneurysm in descending and thoracic-abdominal aorta should be considered when its size is 5.0 cm or larger in good-risk patients.
Clinical Outcomes and the Impact of Anti-Thymocyte Globulin (ATG) and Chronic Graft Versus Host Disease (cGVHD) Following Pediatric Allogeneic Stem Cell Transplantation: A Comparison between Peripheral Blood and Bone Marrow as a Source of Stem Cells.
Authors: Parneet Cheema, Sunil Desai, Ronald Anderson, Max Coppes, Victor A. Lewis
Journal: Blood (2005)
High Resolution Screening of Genomic Aberrations in Follicular Lymphoma Using Microarray Based Comparative Genomic Hybridization (MATRIX-CGH).
Authors: Carsten Schwaenen, Swen Wessendorf, Andreas Viardot, Sandra Ruf, Martina Enz, Holger Kohlhammer, Hans A. Kestler, Thomas F.E. Barth, Peter Moeller, Hartmut Doehner, Peter Lichter, Martin Bentz
Journal: Blood (2004)
Multimodal Dose Dense Therapy for Mantle Cell Lymphoma.
Authors: Sam O. Wanko, Jon P. Gocherman, Joseph O. Moore, Carlos Decastro, Robert Prosnitz, Cristina Gasparetto, John Chute, Mitchell Horowitz, Morris Ashley, Edonds Emily, Davis Patty, Chao J. Nelson, David A. Rizzieri
Journal: Blood (2004)
AB1034 The Epidemiology of The Rheumatic Manifestations Associated with Inflammatory Bowel Disease: The Preliminary Data from A Hospital-Based Cohort Study in Istanbul: Table 1.
Authors: N. Cakir, N. Imeryuz, O. Atug, H. Akin
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rheumatic manifestations are the most common frequent extra-intestinal manifestations (EIM) of inflammatory bowel disease (IBD), which includes Crohn9s disease (CD) and ulcerative colitis (UC), and affected 6–46% of patients<sup>1</sup>. Despite the common manifestations, data on the various ethnic populations are limited so far. Therefore, the cohort study seems a more useful tool to learn more about epidemiology and possible risk factors in the different geographical and racial groups<sup>2</sup>. <h3>Objectives</h3> We conducted this survey to estimate the prevalences of some rheumatic manifestations associated with IBD and to study epidemiological factors of IBD in Istanbul, Turkey. <h3>Methods</h3> The patients were enrolled from the Gastroenterological Out-patient Clinics at two Hospitals. The diagnosis was made by gastroenterologists using endoscopy and histological studies. All patients with established diagnosis of CD and UC were evaluated byr heumatolgogists for EIM. Inflammatory back pain (IBP) was defined according to Calin9s criteria. The modified New York criteria were used to define ankylosing spondylitis (AS) and the European Spondyloarthropathy Study Group criteria for spondyloarthropathy (SpA). <h3>Results</h3> A total of 223 patients diagnosed as IBD.115 ulcerative colltis (UC) and 108 Crohn9sdisease (CD).We estmated the prevalence of IBP as 21%; AS: 2.7%; sacroiliitis (SA): 5.4%; psoriasis: 1.3%; psoriatic arthritis (PsA): 0.9%; pustulosis: 0.9%; uveitis: 1.8%; polyarticular arthritis: 6%; oligoarticular arthritis: 9%; arthralgia: 27%; erythema nodosum (EN): 2.2%; recurrent oral aphthous (ROU): 18.4% (Table 1). <h3>Conclusions</h3> We concluded that AS occurs more frequently in IBD, and more often than the prevalence of AS found in the general population. There is a high prevalence of IBP in IBD. The prevalence of ROU significantly higher than in the health population<sup>3</sup>. <h3>References</h3> Atzeni F, Defendenti C, DittoMC,.etal:Rheumatic manifestations in inflammatory bowel disease. Autoimmun Rev 2014;13(1):20–3. Vavricka SR, Brun L, Ballabeni P, et al.: Frequncy and risk factors for extraintestinal manifestations in the Swiss Inflammatory Bowel Disease Cohort. Am J Gastroenterol 2011;106(1): 110–9. Cakir N, Pamuk ON, Derviş E, et al.: The prevalences of some rheumatic diseases in western Turkey: Havsa study. Rheumatol Int;32(4):895–908. <h3>Disclosure of Interest</h3> None declared
Abstract 16445: Anticoagulation Control, Risk of Overanticoagulation and Major Hemorrhage Among Warfarin Users is Influenced by Race
Authors: Nita A Limdi, Aditi Shendre, Qi Yan, Jonathan Thigpen, Nianjun Liu, Todd M Brown, Charles E Hill, T M Beasley
Journal: Circulation (2015)

Objective: Racial differences in warfarin response have been of significant interest. Differences in dose requirements have been extensively studied. Herein, we assess whether anticoagulation control [percent time in target range (PTTR; INR range 2-3)], risk of overanticoagulation (INR&gt;4) and major hemorrhage differ by race among warfarin users. Methods: The analysis included 1357 participants [595 African Americans (AA); 762 European Americans (EA)]. The Rosendaal interpolation method was used to compute the PTTR, percent time above range (PTAR) and percent time below range (PTBR). Major hemorrhages included serious, life threatening and fatal bleeding events. The influence of race (AA vs. EA) on PTTR, PTBR, and PBAR was evaluated using linear regression; overanticoagulation and hemorrhage by Cox proportional hazards analysis adjusting for clinical and genetic factors. Results: Over 1912 person-years (pyrs) accrued (average per patient 1.4 (± 0.9) years), after adjusting for covariates, compared to EAs, AAs had lower PTTR (56.3% vs. 50.8% p&lt;0.001), higher PTBR (26.5% vs. 31.2%; p=0.001) and were also more likely to experience overanticoagulation (HR: 1.31, 95% CI 1.10-1.56, p=0.003). A total of 156 major hemorrhagic events were encountered (incidence 8.2/100 pyrs, 95% CI: 7.0 – 9.5/100 pyrs). AAs had higher incidence of hemorrhage compared to EAs (IRR: 1.38, 95% CI 1.00-1.89, p=0.046). After adjusting for clinical and genetic factors, AAs remained at a higher risk for hemorrhage (HR: 1.60, 95% CI: 1.10-2.34, p=0.016). Older age, antiplatelet therapy, renal impairment, and possession of CYP2C9 variants increased the risk of hemorrhage. Higher PTTR was associated with a lower risk of hemorrhage in both race groups. Compared to patients with PTTR&lt;50%; those with PTTR 50-60% had a 37% lower risk (HR=0.63; 95%CI0.4-0.97; p=0.04), those with PTTR 60-70% had a 43% lower risk (HR=0.57; 95%CI 0.35-0.92; p=0.02), and those with PTTR &gt;70 had a 75% lower risk (HR=0.25; 95%CI0.14-0.43; p&lt;0.0001). Conclusion and Relevance: Among warfarin users, African Americans spent less time in target INR range, and had a higher risk of overanticoagulation and hemorrhage. Strategies to improve anticoagulation control among African Americans can lower risk of hemorrhage.
THU0472 Evaluation of Trabecular Bone Score in Patients with A Distal Radius Fracture
Authors: H.S. Gong, Y.H. Shin
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Studies have shown that trabecular bone score (TBS) is associated with vertebral and non-vertebral fractures in postmenopausal women, and it may have value for assessing microarchitectural deterioration other than low bone mass. There are limited data on the TBS in patients with a distal radius fracture (DRF), which often occurs in the osteopenic or even normal bone mineral density (BMD) ranges. <h3>Objectives</h3> The purpose of this study was to compare BMD and TBS in patients with a DRF and propensity score-matched control patients. <h3>Methods</h3> We compared BMD and TBS in 269 women with a DRF older than 50 years of age with age- and body mass index (BMI)-matched control patients who had no history of fractures. BMD was measured at the lumbar spine and at the femur using a GE Lunar Prodigy scanner. TBS was calculated on the same spine image. The differences of BMD and TBS between the two groups were assessed. A multivariate logistic regression analysis was used to analyze the odds ratio for the occurrence of DRF for variables such as age, BMI, lumbar or total femur BMD, and the TBS. <h3>Results</h3> Patients with a DRF had significantly lower BMDs at the femur (neck, trochanter and total) than control patients (<i>p</i>=0.004, 0.001 and 0.010, respectively). However, BMDs at the lumbar spine and TBS were not significantly different between the groups (<i>p</i>=0.367 and 0.708, respectively). Multivariate analysis indicated that only total femur BMD was significantly associated with the occurrence of DRF (odds ratio, 0.102; 95% confidence interval, 0.018 – 0.569; <i>p</i>=0.009). <h3>Conclusions</h3> TBS is not different between women with a distal radius fracture and those without a history of fractures. This result suggests that the TBS measured at the lumbar spine, which is mainly trabecular, may not reflect early microarchitectural changes in the distal radius, which is mainly cortical. BMD at the femur is the reliable evaluation of bone frailty in patients with a DRF. <h3>Disclosure of Interest</h3> None declared
FRI0370 Two Subsets of Giant Cell Arteritis Characterized by The Absence or Presence of Spondyloarthritis or Its Associated Diseases
Authors: D. Ernst, N. Baerlecken, R. Schmidt, T. Witte
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Whilst large vessel vasculitis (LVV) predominantly occurs in isolation, associations with other infectious and non-infectious diseases have been reported. Limited data describing associations with various autoimmune diseases, including spondyloarthritis exists. The aim of this study was to characterize the association of LVV and spondyloarthritis or its associated diseases (SpAD). <h3>Methods</h3> A single centre, retrospective study of patients ≥50yrs with first presentation LVV between 01.06.2008–01.06.2015 was performed. Patients were categorized according to SpA or associated disease, other autoimmune disease or controls. Clinical, laboratory and imaging findings were compared. Kaplan-Meyer survival analysis, with relapse taken as the primary end-point, was performed. <h3>Results</h3> LVV was confirmed in 62 pts, of who 16/62 (26%) had SpA or associated disease. In these patients, LVV presented earlier (59.2 SpAD vs. 68.1 AI and 70.3yrs Controls; p=0.01) and occurred predominantly in spring compared to autumn and winter in non-SpA patients, was associated with more centralised pattern of distribution (p=0.05) and was more likely to exhibit a refractory course (p=0.05). Overall relapse rates were similar across groups. Smoking-status influenced age of onset in all groups, being associated with earlier onset. <h3>Conclusions</h3> A clear association between LVV and SpAD exists. LVV associated with SpAD has a particular phenotype characterised by earlier onset, thorax-limited disease and increased risk of a refractory course. Given on-going LVV treatment trials further genetic and pathophysiological characterization appears warranted, to evaluate potential variation in treatment response and optimize future care. <h3>Acknowledgement</h3> Supported by KFO250 <h3>Disclosure of Interest</h3> None declared
Prognostic Factors for the Engraftment in Cord Blood Transplantation: With Units Shipped from Single Cord Blood Bank, Tokyo Cord Blood Bank.
Authors: Tokiko Nagamura-Inoue, Cui Yan, Aya Satomi, Hideo Mugishima, Shigetaka Asano, Tsuneo Takahashi, Hideki Kodo
Journal: Blood (2005)
The expression profile and clinic significance of the SIX family in non-small cell lung cancer
Authors: Qian Liu, Anping Li, Yijun Tian, Yu Liu, Tengfei Li, Cuntai Zhang, Jennifer D. Wu, Xinwei Han, Kongming Wu
Journal: Journal of Hematology & Oncology (2016)

The SIX family homeobox genes have been demonstrated to be involved in the tumor initiation and progression, but their clinicopathological features and prognostic values in non-small cell lung cancer (NSCLC) have not been well defined. We analyzed relevant datasets and performed a systemic review and a meta-analysis to assess the profile of SIX family members in NSCLC and evaluate their importance as biomarkers for diagnosis and prediction of NSCLC. This meta-analysis included 17 studies with 2358 patients. Hazard ratio (HR) and 95 % confidence interval (CI) were calculated to represent the prognosis of NSCLC with expression of the SIX family genes. Heterogeneity of the ORs and HRs was assessed and quantified using the Cochrane Q and I 2 test. Begg's rank correlation method and Egger's weighted regression method were used to screen for potential publication bias. Bar graphs of representative datasets were plotted to show the correlation between the SIX expression and clinicopathological features of NSCLC. Kaplan-Meier survival curves were used to validate our prognostic analysis by pooled HR. The systematic meta-analysis unveiled that the higher expressions of SIX1-5 were associated with the greater possibility of the tumorigenesis. SIX4 and SIX6 were linked to the lymph node metastasis (LNM). SIX2, SIX3, and SIX4 were correlated with higher TNM stages. Furthermore, the elevated expressions of SIX2, SIX4, and SIX6 predicted poor overall survival (OS) in NSCLC (SIX2: HR = 1.14, 95 % CI, 1.00–1.31; SIX4: HR = 1.39, 95 % CI, 1.16–1.66; SIX6: HR = 1.18, 95 % CI, 1.00–1.38) and poor relapse-free survival (RFS) in lung adenocarcinoma (ADC) (SIX2: HR = 1.42, 95 % CI, 1.14–1.77; SIX4: HR = 1.52, 95 % CI, 1.09–2.11; SIX6: HR = 1.25, 95 % CI, 1.01–1.56). Our report demonstrated that the SIX family members play distinct roles in the tumorigenesis of NSCLC and can be potential biomarkers in predicting prognosis of NSCLC patients.
Periosteum tissue engineering in an orthotopic in vivo platform
Authors: J.G. Baldwin, F. Wagner, L.C. Martine, B.M. Holzapfel, C. Theodoropoulos, O. Bas, F.M. Savi, C. Werner, E.M. De-Juan-Pardo, D.W. Hutmacher
Journal: Biomaterials (2016)
Specific and Recurrent Cytogenomic Abnormalities Originate in the Spleens of Myelofibrosis Patients and Contribute to Clonal Diversity and Disease Progression
Authors: Vesna Najfeld, Joseph Tripodi, Xiaoli Wang, Myron Schwartz, Marina Kremyanskaya, Edward Cytryn, Sharon Zirkiev, Raajit K. Rampal, John O Mascarenhas, Ronald Hoffman
Journal: Blood (2014)
P07.20 Combination of the radiotherapy and targeted magnetic nanoparticles in the theranostics of the Hsp70-positive brain tumors
Authors: M. Shevtsov, S. Stangl, I. Riederer, W. Sievert, M. Parr, Y. Marchenko, L. Yakovleva, B. Nikolaev, V. Ryzhov, G. Multhoff
Journal: Neuro-Oncology (2016)
The 1% Club
Authors: Michelle M. Kittleson
Journal: JAMA Cardiology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Association of Genetic Variation in the Catechol-O-Methyl Transferase Gene with Pain and Six Minute Walk Distance in Sickle Cell Anemia Patients From the Walk-PHaSST Study
Authors: Yingze Zhang, Qilu Zeng, Inna Belfer, Ruchika Goel, Martha Porter, Yanxia Chu, Robyn J. Barst, Kathryn L. Hassell, Roberto F Machado, Jonathan C. Goldsmith, Mark T Gladwin, Lakshmanan Krishnamurti
Journal: Blood (2011)
Piebaldism in History—“The Zebra People”
Authors: Amy Huang, Sharon A. Glick
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
A Genome-Modified Mouse Line with an Insertion Mutation at the AML1/Runx1 Gene Locus Detected from a Patient with Myelodysplastic Syndrome.
Authors: Yoko Fukushime-Nakase, Mitsushige Nakao, Shigeo Horiike, Motohiro Nishimura, Masafumi Taniwaki, Tohru Sugimoto, Tsukasa Okuda
Journal: Blood (2005)
Transmission of a Follicular Lymphoma by Allogeneic Bone Marrow Tranplantation — Evidence to Support the Existence of a Lymphoma Progenitor Cell.
Authors: Jason Hart, A. Robert Turner, Loree M. Larratt, James A. Russell, Bevin Franko, Christine Frantz, Teresa Paonessa, Adnan Mansoor, Raymond Lai
Journal: Blood (2006)
Expression and in Vitro Binding of Protease Activated Receptor1 (PAR1) with Novel Anti-PAR1 Molecules: Data on Fresh Myeloma Marrow Plasma Cells and Human Myeloma Cell Lines
Authors: Meral Beksac, Pinar Ataca, Berna Atesagaoglu, Klara Dalva, Andry Nur Hidayat, Ismail Yalcin, Esin Yalcin Aki, Tulin Ozkan, Xenofon Papanikalaou, Saad Z Usmani, Erming Tian
Journal: Blood (2015)
Mechanisms of Effort Intolerance in Patients With Rheumatic Mitral Stenosis
Authors: Michal Laufer-Perl, Yaniv Gura, Jason Shimiaie, Jack Sherez, Gregg S. Pressman, Galit Aviram, Simon Maltais, Ricki Megidish, Amir Halkin, Meirav Ingbir, Simon Biner, Gad Keren, Yan Topilsky
Journal: JACC. Cardiovascular imaging (2016)