tbuckley/cabot-search huggingface dataset:
PTH-066 An Audit To Assess Feasibility And Efficacy Of Group Education For Irritable Bowel Syndrome (ibs) Patients In The Delivery Of Low Fodmap (fermentable Oligosaccharides, Disaccharides, Monosaccharides And Polyols) Dietary Advice
Authors: SK Kinrade, RM Twamley, L Fell, L Heald, A Healy
Journal: Gut (2014)

<h3>Introduction</h3> A low FODMAP diet has demonstrated symptom improvement in patients with IBS when conducted during individual consultations.<sup>1</sup> Structured dietetic group education is a well recognised medium for encouraging self-management and promoting confidence in patients with chronic illness<sup>.2</sup> There is a lack of research in the use of low FODMAP dietary intervention in a group setting. This audit was conducted to assess the efficacy and feasibility of providing low FODMAP dietary advice in a group environment. <h3>Methods</h3> Data was collected using the ‘IBS satisfaction survey’<sup>3 </sup>which was given to 17 patients with IBS on completion of the 8 week low FODMAP diet. The following question was used to monitor effectiveness of the low FODMAP diet: ‘Do you currently have satisfactory relief from your gut symptoms’? This is a closed question, completed anonymously, with a choice response of ‘yes’ or ‘no’. Feasibility of a group format was measured via attendee’s feedback and non-attendance (DNA) rate. Feedback was collected using an evaluation questionnaire (6 point Likert scale – very satisfied, satisfied, acceptable, dissatisfied, very dissatisfied, unsure) after the group session. <h3>Results</h3> 21 patients attended the initial session. 4 patients (19%) failed to attend the follow up session. 82% (14 /17) of patients who completed the education programme reported satisfactory relief of gut symptoms. 100% of patients were ‘satisfied’ or ‘very satisfied’ with the presentation and group discussion. 94% were ‘satisfied’ or ‘very satisfied’ with the organisation of the group session. <h3>Conclusion</h3> Group education for low FODMAP diet therapy is a feasible and effective method for promoting symptom improvement for IBS patients. Group education has the potential to be at least as effective as one-to-one low FODMAP IBS education. Further randomised control studies with large sample sizes are recommended. <h3>References</h3> 1 Halmos EP, Power, VA, Shepherd SJ, Gibson PR, Muir JG. Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome. <i>Gastroenterology</i> 2014;146(1): pp67–75 2 Keen AJ, Duncan E, McKillop-Smith A, Evans ND, Gold AE. Dose Adjustment for normal eating (DAFNE) in routine clinical practice: who benefits? <i>Diabetes Medicine</i> 2012;29(5):pp670–6 3 Staudacher HM, Whelan K, Irving PM, Lomer MC. Comparison of symptom response following advice for a diet low in fermentable carbohydrates (FODMAPs) versus standard dietary advice in patients with irritable bowel syndrome. <i>Journal of Human Nutrition and Dietetics</i>, 2011;24(5):pp487–95 <h3>Disclosure of Interest</h3> None Declared.
Regional Cardiac Dilatation after Acute Myocardial Infarction
Authors: Leland W. Eaton, James L. Weiss, Bernadine H. Bulkley, John B. Garrison, Myron L. Weisfeldt
Journal: New England Journal of Medicine (1979)

To assess the early topographic changes after acute transmural myocardial infarction, we studied 28 patients during the first two weeks after infarction by serial two-dimensional echocardiography. Regional end-diastolic segment lengths and wall thicknesses for anterior and posterior left ventricular walls were calculated. Eight patients showed infarct expansion, with disproportionate dilatation and transmural thinning in the infarcted zone, that was significantly different (P<0.005) from changes in non-infarcted regions. This regional expansion led to an overall left ventricular dilatation in these eight patients of 25 per cent compared to 5 per cent in the 20 patients without infarct expansion. Although the eight patients with regional expansion did not have significantly higher peak creatine kinase or Killip classification, they had a significantly greater eight-week mortality (four of eight versus none of 20, P<0.004). Thus, regional cardiac dilatation may be an early, lethal consequence of transmural infarcts, and appears to be an important mechanism of acute cardiac dilatation after myocardial infarction. (N Engl J Med 300:57–62, 1979)
Final Results of a Randomized Phase II Study Demonstrating Efficacy and Safety of BSI-201, a Poly (ADP-Ribose) Polymerase (PARP) Inhibitor, in Combination with Gemcitabine/Carboplatin (G/C) in Metastatic Triple Negative Breast Cancer (TNBC).
Authors: J. O'Shaughnessy, J. O'Shaughnessy, J. O'Shaughnessy, C. Osborne, C. Osborne, C. Osborne, J. Pippen, J. Pippen, J. Pippen, D. Patt, D. Patt, C. Rocha, V. Ossovskaya, B. Sherman, C. Bradley
Journal: Cancer Research (2009)

Abstract Background: TNBC is an aggressive breast cancer subtype which shares molecular and pathologic features with BRCA1-related breast cancers. BRCA-deficient cells are sensitive to inhibition of PARP1, a critical enzyme of cell proliferation and DNA repair, and thus represent a rational target of PARP inhibitor-based cancer therapy. The objectives of this study were to evaluate BSI-201, a potent PARP1 inhibitor, in combination with G/C in subjects with metastatic TNBC. Methods: Eligible subjects had measurable disease and received ≤2 prior cytotoxic regimens for ER-, PR-, and HER2-negative metastatic breast cancer. Patients were randomized (1:1) to G/C alone or G/C + BSI-201. Gemcitabine (1000 mg/m2; IV) and carboplatin (AUC = 2; IV) were given on days 1 and 8, and BSI-201 (5.6 mg/kg; IV) on days 1, 4, 8, and 11 every 21 days. Endpoints were clinical benefit rate (CBR = CR + PR + SD ≥6 months), objective response rate (ORR), progression-free survival (PFS) and overall survival (OS). Results: Preliminary analyses of all 116 dosed patients showed that, based on all patient visits through March 2009, BSI-201 + G/C improved CBR, ORR, median PFS, and median OS, compared with G/C alone. The frequency and nature of adverse events did not differ between arms. G/CG/C+BSI-201Hazard Ratio (n=57)(n=59)(95% CI)P valueCBR, %2162 0.0002ORR, %1648 0.002Median PFS, months3.36.90.34 (0.20-0.58)&amp;lt;0.0001Median OS, months5.79.20.35 (0.19-0.65)0.0005 Conclusions: This analysis demonstrates that BSI-201 + G/C improved patient's outcomes, as measured by CBR, ORR, PFS and OS, compared with G/C alone. BSI-201 + gemcitabine/carboplatin was well tolerated and did not potentiate chemotherapy-related toxicities. Final data on CBR and ORR, as well as updated analyses of PFS and OS for all 116 dosed patients will be presented based on all patient visits through September 2009. Exploratory correlative analyses of PARP expression and overall clinical response will also be presented, as well as initial correlative analyses between number of metastatic therapies and clinical response. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 3122.
ROBOTIC VERSUS MANUAL PERCUTANEOUS CORONARY INTERVENTION: EFFECT ON PROCEDURE TIME FOR SIMPLE AND COMPLEX LESIONS
Authors: Jesse J. Naghi, Jonathan Harrison, Lawrence Ang, Omid Behnmafar, Song Cui, John Bahadorani, Arturo Dominguez, Ryan Reeves, Mitul Patel, Ehtisham Mahmud
Journal: Journal of the American College of Cardiology (2016)
Abstract 603: Overexpression of G protein-coupled receptor kinase 2 in hepatocellular carcinoma cells suppresses proliferation by inducing G2/M phase arrest
Authors: Zhengyu Wei, Reginald Hurtt, Cataldo Doria
Journal: Cancer Research (2011)

Abstract G protein-coupled receptor kinase 2 (GRK2) was originally identified as a key player in G protein-coupled receptors desensitization. A growing body of evidence has demonstrated that GRK2 may have broader ‘effector” functions by interacting with a variety of non-receptor signaling proteins and involves in the regulation of many cellular processes such as proliferation, cell cycle progression and migration. In this study, we investigated the role of GRK2 in human hepatocellular carcinoma (HCC) cells. We screened five HCC cell lines and found that Huh7 and Mahlavu had the highest and lowest of basal GRK2 expression levels respectively. We then overexpressed wild type (WT) GRK2 and its kinase-dead mutant (K220R) in these two HCC cells using recombinant adenoviruses. We found that only WT GRK2 overexpression but not the K220R mutant overexpression significantly reduced cell viability. We thus performed BrdU incorporation assay and found that only WT GRK2 overexpression reduced cell proliferation. We further examined this anti-proliferative function by propidium iodide staining to analyze cell cycle progression. Our data showed that enhanced WT GRK2 induced cell cycle arrest at G2/M phase, from 21.4% to 41.8% in Huh7 and 25.9% to 48.4% in Mahlavu, respectively. Furthermore, our western blotting results showed that overexpression of GRK2 induced the up-regulation of p53 (Ser15) phosphorylation and Cyclin B1 in a dose dependent manner. Our results indicated that overexpression of GRK2 had a profound suppressive effects on HCC cell growth and suggested that gene transfer of GRK2 may open a new therapeutic option for the treatment of human HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 603. doi:10.1158/1538-7445.AM2011-603
Abstract 1626: The impact on tumor-stromal interactions of loss of collagen XV from the basement membrane zone.
Authors: Anthony G. Clementz, Michael Mutolo, Ann Harris
Journal: Cancer Research (2013)

Abstract Most clinical therapeutics used to date depend on specific targeting of cellular components to treat cancers. However, the environment outside the tumor cell is also critical since it may provide new targets to treat malignant and resistant cancers, independent of the tumor. We aim to target the early stages of cancer, prior to metastasis by determining the role of a non-fibrillar collagen (Type XV) and its interactions with the tumor stroma and extracellular environment. Type XV collagen (COLXV) is found in basement membrane zones where it assumes a pretzel-like structure but unlike the majority of fibrillar collagens does not form tight lattice networks surrounding the cell. In aggressive cancers, including breast, pancreas, ovarian and melanomas, Loss of COLXV precedes basement membrane invasion and metastasis. Moreover, the loss of COLXV from the distal side of basement membrane zones and the resulting deficit in its interactions with other proteins may determine its specific function in tumor progression and eventual metastasis. In this context we have identified critical collagen-binding cell surface receptors on the tumor cell, which interact with COLXV and appear to mediate its functions. A number of these interacting proteins show altered signaling in cancer. We previously showed that over-expression of COLXV in cervical cancer cells alters the growth properties of these cells in vitro and that type XV collagen is a dose-dependent suppressor of tumorigenicity in vivo. We now show that over-expression of COLXV inhibits epithelial to mesenchymal transition (EMT) in vitro through interactions with cell surface receptors and has a dramatic effect on the associated signaling events and alterations on the tumor cell periphery. Alterations in the balance of downstream signaling events may be responsible for tumor progression after the loss of COLXV. We are now further investigating the mechanisms of tumor/stroma crosstalk that are impacted by COLXV and subsequently by its depletion. Citation Format: Anthony G. Clementz, Michael Mutolo, Ann Harris. The impact on tumor-stromal interactions of loss of collagen XV from the basement membrane zone. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1626. doi:10.1158/1538-7445.AM2013-1626
820 A FOUR GENE MOLECULAR SIGNATURE IS BETTER THAN IL28B POLYMORPHISM TO PREDICT TREATMENT RESPONSE TO PEGYLATED-INTERFERON AND RIBAVIRIN IN CHRONIC HEPATITIS C
Authors: T. Asselah, I. Bieche, B. Jardin-Watelet, A. Duces, M. Lapalus, S. De Muynck, E. Dupas, N. Jullian, I. Molina, N. Lambert, E. Nicolas, B. Sallenave, M. Blanuet, E. Estrabaud, M. Martinot-Peignoux, O. Lada, D. Valla, P. Bedossa, D. Laune, P. Marcellin, M. Vidaud
Journal: Journal of Hepatology (2012)
Improvement in Diagnosis of Metastatic Pituitary Carcinoma by 68Ga DOTATATE PET/CT
Authors: Jianqi Xiao, Zhaohui Zhu, Dingrong Zhong, Wenbin Ma, Renzhi Wang
Journal: Clinical Nuclear Medicine (2014)

Pituitary carcinoma is a rare disease with a challenge in both diagnosis and treatment. A 50-year-old female patient who underwent transsphenoidal resection of a pituitary tumor experienced progressive headache. For the evaluation, Ga DOTATATE PET/CT was used and compared with F-FDG PET/CT and enhanced MRI. Multiple lesions were detected by Ga DOTATATE PET/CT at the cerebral cortex, cerebellum, and cerebellopontine angle with a higher contrast than F-FDG PET/CT and enhanced MRI. With a biopsy, the patient was diagnosed as metastatic pituitary carcinoma. Moreover, it thus presents potential therapeutic implications on molecular-targeted therapy using somatostatin analogs and peptide receptor radionuclide therapy targeting the somatostatin receptors.
Chronic Renal Brucellosis
Authors: Horace H. Zinneman, Harry Glenchur, Wendell H. Hall
Journal: New England Journal of Medicine (1961)

PYELONEPHRITIS and renal abscess have been reported as complications of brucellosis.1 2 3 4 5 6 7 8 9 The present case deserves documentation because of the rarity of the occurrence of this form of the infection. Moreover, the immunologic observations made in the course of this patient's illness clarify the clinical usefulness of some recent concepts of immunity in brucellosis.10 11 12 Case ReportK.T.B., a 30-year-old man, was admitted to the Minneapolis Veterans Administration Hospital on March 2, 1960, because of dysuria and a weight loss of 18.1 kg. (40 pounds). Since he was 8 years of age, the dairy needs of his family had been supplied by . . .
Diffuse Hepatic and Splenic Uptake of Tc-99m Methylene Diphosphonate on Bone Scintigraphy After Intravenous Administration of Gadolinium-Containing MRI Contrast
Authors: Ximin Shi, Hongli Jing, Hongming Zhuang, Yingqiang Zhang, Xiaona Jin, Fang Li
Journal: Clinical Nuclear Medicine (2011)

Three patients with known lung cancer came on different days to our department to have a bone scan to evaluate possible osseous metastatic disease. The bone scan images showed increased Tc-99m methylene diphosphonate (Tc-99m MDP) activity in the liver and to a lesser degree in the spleen, whereas bone scan images from other patients on the same days showed no abnormal activity in the liver or spleen. On the same day, shortly before the bone scan, all 3 patients had a magnetic resonance imaging scan with an intravenous injection of Magnevist (Gadolinium-DTPA), which was not previously known to cause an altered Tc-99m MDP distribution. In the follow-up bone scans performed within 1 week of the initial bone scintigraphy, images from none of these 3 patients showed abnormal liver or spleen activity. The findings indicated that the increased Tc-99m MDP activity in the liver and spleen in the early studies was indeed an effect of Gadolinium-containing magnetic resonance imaging contrast. This effect was further confirmed by an animal experiment.
EPID-32PROTEIN-SPECIFIC ANTIBODY RESPONSES TO VARICELLA AND CYTOMEGALOVIRUS IN GLIOMA PATIENTS COMPARED TO CONTROLS
Authors: Joseph Wiemels, Paige Bracci, Mi Zhou, Lucie McCoy, Helen Hansen, Terri Rice, Kyle Walsh, Stephen Francis, John Wiencke, Margaret Wrensch
Journal: Neuro-Oncology (2015)

An etiologic role of neurotropic viruses in glioma is supported by epidemiologic and clinical observations. Glioma patients consistently report a lower history of clinical responses to varicella (VZV, chickenpox and shingles). Pathologic and clinical evidence for an active role of Cytomegalovirus (CMV) in gliomagenesis is also accumulating, though the subject remains controversial. We hypothesized that the neurotropic location of viral latency and subsequent patient-restricted response to these infections may impact efficacy of immune response against glioma, affecting incidence of the disease as well as survival in those afflicted. We explored the viral protein-restricted response against 99 VZV and 156 CMV protein antigens using Nucleic Acid Programmable Protein Arrays (NAPPA) in serum samples from 45 glioma patients and 45 controls from the University of California, San Francisco Adult Glioma Study (AGS). The proportion of agreement between the NAPPA positivity for CMV and VZV reactivity with traditional ELISA whole virus serological assay was 86% and 95%, respectively (Cohen's Kappa 0.72 and 0.9, respectively). Cases were more likely to have complex reactions to 5 or more antigens of VZV (p = 0.03). Cases reacted more strongly to specific proteins including Orf12, Orf14, and Orf49 (p < 0.03), and antigen recognition was strikingly stronger among cases for Orf23 and Orf9, a viral capsid and tegument protein, respectively. Multivariable analysis pointed towards significant differences between cases and controls for Orf9, Orf37, and Orf44. For CMV, protein reactivity was also stronger in cases for the specific proteins UL25, TRS1, and UL48a, also capsid and tegument proteins. Ongoing studies will assess (1) anti-VZV antigens in prediagnostic sera from glioma cases and matched controls in the PLCO cohort study and (2) the role of antibody reactions in survival of glioma patients within AGS. Specific differences in reactivity to these Herpesviruses may promote strategies for glioma prevention and therapies.
Has a fully three-dimensional space map never evolved in any species? A comparative imperative for studies of spatial cognition
Authors: Cynthia F. Moss
Journal: Behavioral and Brain Sciences (2013)

Abstract I propose that it is premature to assert that a fully three-dimensional map has never evolved in any species, as data are lacking to show that space coding in all animals is the same. Instead, I hypothesize that three-dimensional representation is tied to an animal's mode of locomotion through space. Testing this hypothesis requires a large body of comparative data.
AORTIC CALCIFICATION IS ASSOCIATED WITH LEFT VENTRICULAR HYPERTROPHY AND DIASTOLIC DYSFUNCTION IN ELDERLY MALE PATIENTS WITH HYPERTENSION
Authors: In-Jeong Cho, Hyuk-Jae Chang, Hyung-Bok Park, Ran Heo, Chi Young Shim, Geu-Ru Hong, Namsik Chung
Journal: Journal of the American College of Cardiology (2015)
Abstract 4180: The L360R point mutation in the DNA repair gene XRCC1 suppresses tumor progression
Authors: Christina Pettan-Brewer, Jorming Goh, Rebecca Coil, Linda Enns, John Morton, Warren Ladiges
Journal: Cancer Research (2010)

Abstract Variations in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) have been increasingly reported in cancer epidemiology investigations, but have yielded conflicting results and are lacking biological data. XRCC1 is an essential scaffolding protein that interacts with many proteins associated with base excision repair and single-strand break repair. Several polymorphisms and point mutations have been shown to be in the BRCT1 binding domain, where critical binding with the DNA damage sensor gene Poly (ADP-ribose) polymerase (PARP) occurs. The point mutation L360R interferes with PARP binding in cell culture systems. In order to further investigate the biological effects of L360R, we constructed a gene-targeted mouse line and showed the homozygous genotype to be embryonic lethal. We therefore used the heterozygous genotype to determine tumor susceptibility and showed that subcutaneously implanted B16 melanoma tumors developed more slowly in L360R mutant mice compared to wild type littermates (tumor volume 116±11 mm3 vs 263±21 mm3, respectively, p≤0.05) suggesting host mediated affects. We conducted a second experiment using azoxymethane (10mg/kg once a week for 6 weeks) to induce colon tumors and showed that after six months the tumor burden was 14.2±3 mm3 in mutants compared to 22.5±5 mm3 in wild type littermates (p≤ 0.05). These findings suggest that the XRCC1 L360R point mutation acts as a tumor suppressor, possibly through host mediated events. The molecular mechanism for the suppression is not yet known, but the XRCC1 L360R mouse line is a promising animal model to further investigate and determine the clinical relevance of this novel observation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4180.
West Nile virus surveillance in mosquitoes, April to October 2013, Vojvodina province, Serbia: implications for the 2014 season
Authors: G Kemenesi, B Krtinić, V Milankov, A Kutas, B Dallos, M Oldal, N Somogyi, V Németh, K Bányai, F Jakab
Journal: Eurosurveillance (2014)

After the West Nile virus (WNV) outbreak in 2012, we collected mosquito samples from Vojvodina province, Serbia, in 2013. We found high WNV infection rate in two species, Culex pipiens and Anopheles maculipennis. Phylogenetic analysis showed that Serbian WNV strains from 2013 were most closely related to Italian and Greek strains isolated in 2012 and 2010, respectively. Public health authorities should be aware of a potentially increased risk of WNV activity during the 2014 season.
TERAPÉUTICA GUIADA POR ECOENDOSCOPIA DE NECROSIS Y COLECCIONES LÍQUIDAS PANCREÁTICAS
Authors: B Merino Rodríguez, C González Asanza, O Nogales Rincón, L Pérez Carazo, A Ochoa, E Cos, P Menchén Fernández Pacheco
Journal: Endoscopy (2012)

Objetivos: Determinar los resultados inmediatos y a largo plazo de la necrosectomía y el drenaje de colecciones fluidas pancreáticas (pseudoquistes y abscesos) sintomáticas por vía endoscópica Material y método: Los datos de 44 pacientes con colecciones sintomáticas pancreáticas (diámetro medio: 9,8cm, rango 5–21cm; pseudoquistes: 10/44, abscesos: 25/44, necrosis: 9/44) en el periodo comprendido entre enero 2008 a abril de 2012 fueron analizados de manera retrospectiva. Resultados: La técnica de drenaje endoscópico se realizó guiada por ultrasonografía con punción vía transgástrica o transduodenal. Necrosectomía endoscópica se llevó a cabo en 14/44 (abscesos: 5/25; necrosis infectada: 9/9). Las complicaciones inmediatas del procedimiento fueron hemorragia (2/44) (con necesidad de embolización en un paciente y de abordaje quirúrgico en otro), retroneumoperitoneo sintomático (2/44) (resuelto en ambos casos con tratamiento conservador), embolia pulmonar (1/44) siendo el paciente éxitus. Éxito técnico inicial se logró en 42/44 (95,5%) y la resolución clínica de las colecciones se logró mediante endoscopia en 40/44 (90,91%). En 4 pacientes fue necesario abordaje quirúrgico de las colecciones por recidiva de las mismas (a consecuencia de lesiones a nivel del CPP no solucionables endoscópicamente) Tras un seguimiento medio de 21 meses aparecieron pseudoquistes en dos pacientes con necrosectomía previa (uno resuelto espontáneamente y otro que se resolvió con abordaje endoscópico) y dolor recurrente de mal control médico que requirió abordaje quirúrgico en un paciente por síndrome del ducto pancreático desconectado. No existieron otras complicaciones en el resto de pacientes tratados. Conclusiones: El drenaje endoscópico de colecciones pancreáticas sintomáticas es seguro y eficaz tanto a corto como a largo plazo. El riesgo de complicaciones graves se incremente si se realiza necrosectomía pancreática.