tbuckley/cabot-search huggingface dataset:
THU0157 Tripterygium WILFORDII multiglycoside combined regimen as long-term maintenance therapy in chinese rheumatoid arthritis patients
Authors: F. Lian, Y. Wang, H. Xu, D. Chen, Z. Zhan, L. Liang, Q. Qiu, Y. Ye, X. Yang
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Long-term use of traditional and biologic disease-modifying anti-rheumatic drugs (DMARDs) has been applied to achieve the goal of rheumatoid arthritis (RA) treatment. Despite the proven efficacy of DMARDs, there is concern of increased risk of side effects in the long-term therapy. DMARD sparing agents with lower toxicity were required to be identified for modification of the therapeutic strategies. Tripterygium wilfordii multiglycoside (GTW), an authorized Chinese patent drug, has been used for the treatment of autoimmune diseases for decades in China[1]. We retrospectively reviewed 268 RA patients treated with GTW combined DMARDs or DMARDs without GTW for maintenance therapy, compared the efficacy, observed side effects and preliminarily explore the dose reduction or discontinuation protocol of some label DMARDs. <h3>Objectives</h3> To evaluate the efficacy and safety of Tripterygium wilfordii multiglycoside combined therapy as long-term maintenance therapy in the treatment of rheumatoid arthritis. <h3>Methods</h3> We retrospectively reviewed 268 patients with rheumatoid arthritis between 2006 and 2008 in south China who received MTX, etanercept, or GTW combined MTX/etanercept regimens as maintenance therapy. After a standard treatment to target based on MTX or MTX in combination with etanercept as induction therapy, GTW (target dose: 1.8 g/day) were given to the patients with sufficient response to baseline DMARDs. Baseline MTX and/or etanercept was continued for another three months after remission, then stepped down every three months until discontinuation of etanercept and half of the MTX dose at the onset. The patients were followed up for 3 years. Details of the clinical presentation, serological, immunological variables and side effects were collected. <h3>Results</h3> In patients receiving maintenance therapy with combined GTW, disease activity score (DAS28) and x-ray changes were similar to the patients receiving usual treatment. More than half of the patients treated with combined GTW had no radiographic progression over 3 years, compared with those treated with usual dose of MTX and/or etanercept (63.4% vs 69.6%; p&gt;0.05). Improvements in laboratory measurements and physical functions were comparable. Drug related toxicities including abnormal liver function, infection and gastrointestinal intolerance, etc were significantly lower in GTW group. <h3>Conclusions</h3> GTW was a well tolerated and effective DMARD sparing agents in the maintenance therapy of rheumatoid arthritis. Concomitant GTW decreased the exposure to MTX and etanercept, thus reduced the correlative side effects. <h3>References</h3> Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J Ethnopharmacol. 2011; 135 (2): 270-7. <h3>Disclosure of Interest</h3> None Declared
More precise targeting of drugs in pipeline
Authors: A. Tonks
Journal: BMJ (1998)

Three teams of researchers from Germany, France, and the United States have developed new and more precise ways of targeting drugs at diseased tissues.

They report successfully using electric currents, tiny porous beads, and impregnated acetate discs to deliver large molecules—genes, antibodies, and proteins—directly to their targets, bypassing the gut and blood stream, where they would normally be broken down ( Nature Biotechnology 1998;16:159-71). These techniques, although not yet perfected in humans, have the potential to deliver small quantities of highly effective agents, including genes, into cancers and diseased coronary blood vessels without the side effects associated with pills and intravenous or intramuscular injections.

The German team, from the Max Planck Institute for Physiological Research in Bad Nauheim, used porous microspheres no bigger than the inside of a capillary to deliver fibroblast growth factor directly into the small vessel network in pig hearts. Fibroblast growth factor …
IMPACT OF PARAVALVULAR REGURGITATION ASSESSED BY A 5-CLASS GRADING SCHEME ON 1-YEAR OUTCOMES IN THE PARTNER-II SAPIEN 3 HIGH RISK / OPERABLE COHORT
Authors: Philippe Pibarot, Rebecca Hahn, Neil Weissman, Howard Herrmann, Vinod Thourani, Susheel Kodali
Journal: Journal of the American College of Cardiology (2016)
SAT0190 Long-Term Follow-Up of 280 Patients with Mixed Connective Tissue Disease
Authors: A. Hajas, P. Szodoray, B. Nakken, G. Nagy, Z. Szekanecz, E. Bodolay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Mixed connective tissue disease (MCTD) is a systemic autoimmune disorder, accompanied by chronic inflammation involving several organs. MCTD was first described by “Sharp et al.” in 1972 but there is still little known about the long-term outcome of patients and factors influencing the mortality in MCTD. <h3>Objectives</h3> To study the survival rate and prognostic indicators of MCTD in a large Hungarian patient population. <h3>Methods</h3> Two hundred and eighty patients with MCTD diagnosed between 1979 and 2011 were prospectively followed. Clinical features, autoantibodies and mortality data were assessed. Prognostic factors for survival were investigated and survival was calculated from the time of the diagnosis by Kaplan-Meier method. <h3>Results</h3> A total of 22 of 280 patients died during the follow-up period: the causes of death were pulmonary arterial hypertension (PAH) in 9 patients, thrombotic thrombocytopenic purpura in 3 patients, infections in 3 patients and 7 patients died due to cardiovascular events. The 5, 10, 15 year survival rates after the diagnosis was established were 98%, 96% and 88%. The deceased patients were younger at the diagnosis of MCTD compared to those patients who survived (35.5±10.4 vs. 41.8±10.7 years; p&lt;0.03), while there was no difference in the duration of the disease (p=0.835). Our cohort study showed that the presence of cardiovascular events (p&lt;0.0001), esophageal hypomotility (p=0.04), serositis (p&lt;0.001), secondary antiphospholipid syndrome (p=0.039) and malignancy (p&lt;0.001) was significantly higher in the deceased MCTD patients. The presence of anti-cardiolipin (p=0.019), anti-β2-glycoprotein I (p=0.002) and anti-endothelial cell antibodies (p=0.002) increased the risk of mortality. <h3>Conclusions</h3> Overall, PAH remained the leading cause of death in patients with MCTD. The prevalence of cardiovascular morbidity and mortality, malignancy and thrombotic events is increasing during the disease course of MCTD and these factors negatively influence the survival. The presence of antiphospholipid antibodies raised the risk of mortality. <h3>Disclosure of Interest</h3> None Declared
615 HOW USEFUL IS ACOUSTIC RADIATION FORCE IMPULSE ELASTOGRAPHY (ARFI) TO PREDICT THE PRESENCE OF SIGNIFICANT ESOPHAGEAL VARICES IN CIRRHOTIC PATIENTS?
Authors: S. Bota, I. Sporea, R. Sirli, M. Focsa, A. Popescu, M. Strain, M. Danila
Journal: Journal of Hepatology (2012)
Abnormalities of dynamic ventricular shape change in patients with aortic and mitral valvular regurgitation: assessment by Fourier shape analysis and global geometric indexes.
Authors: D A Kass, T A Traill, M Keating, P I Altieri, W L Maughan
Journal: Circulation Research (1988)

The normal cardiac cycle is associated with dynamic changes in left ventricular shape, which can be disturbed in disease states. To assess the influences of diastolic volume, percent ejected volume, and abnormalities of acute or chronic systolic loading on general and detailed chamber geometry, we studied dynamic shape change recorded by x-ray contrast ventriculography in both normal patients and those with aortic (AR) or mitral (MR) valve regurgitation. While both lesions increased diastolic volume, the character of load throughout ejection differed markedly. Detailed cavity geometry was assessed by a Fourier analysis technique and general shape by eccentricity and circularity indexes. Normal hearts, showed increased systolic elongation by all indexes. AR patients displayed a similar rise in eccentricity during ejection; however, the extent of shape change when measured by Fourier and circular indexes was reduced. In contrast, MR patients displayed enhanced systolic shape change, particularly in chamber elongation. Neither simple eccentricity of circular indexes adequately differentiated these shape abnormalities, whereas detailed Fourier geometric analysis precisely characterized the abnormalities of shape change in these two diseases. Relations between the extent of shape change and ejected volume for each patient group revealed significantly more systolic deformation with a different shape versus volume relation for the MR hearts as compared with AR and controls. Thus, while dynamic left ventricular shape is certainly influenced by the extent of volume change, it also varies independently from volume related to the specific nature of loading during ejection.
Evaluation of a new 30-MHz Three-Dimensional ultrasonic probe and software for real-time image reconstructions of gastrointestinal lesions
Authors: T Kakemura, S Itoh, Y Saigusa, Y Nemoto, S Fujinuma
Journal: Endoscopy (2006)

Background and Purpose: High-frequency ultrasonic probes in endoscopic ultrasonography (EUS) are increasingly employed to evaluate gastrointestinal lesions. In the three-dimensional (3D) reconstruction of data obtained by helical scanning, both radial and linear ultrasound images are displayed on a monitor in real time, however, reconstruction of the surface-rendering image (SRI) inside a digestive tract requires an offline viewing system (MAJ-2000; Olympus). The purpose of this study was to evaluate the use of a new 30-MHz 3D probe (XUM-DP30–25R; Olympus) and 3D software (MAJ-1330; Olympus) for real-time data reconstruction.
Evaluation of variants in BRIP1, PALB2 and CHEK2 in a west of Ireland breast cancer cohort.
Authors: NM Mc Inerney, N Miller, A Rowan, G Colleran, C Curran, T Ian, S Eli, KJ Michael
Journal: Cancer Research (2009)

Abstract Abstract #3092 Introduction&amp;#x2028; Positive family history is the most important risk factor in breast cancer predisposition. Recent studies have identified variants in BRIP1, PALB2 and CHEK2, which have been proposed as breast cancer susceptibility genes conferring an increased relative risk of 2-4%.&amp;#x2028; Aims&amp;#x2028; To evaluate the role of the above variants in the West of Ireland population and to examine their potential clinical relevance.&amp;#x2028; Methods&amp;#x2028; Proposed candidate genetics variants in BRIP1, PALB2 and CHEK2 were interrogated in 192 patients with a high risk of familial breast cancer. Genescan analysis and direct sequencing were used to evaluate these variants. Where a variant was exhibited, it was then examined further in 990 sporadic breast cancer patients and 1016 matched non-cancer controls using KASPar genotyping technology.&amp;#x2028; Results&amp;#x2028; We demonstated mutations in BRIP1 and CHEK2 genes. 1 mutation was found in BRIP1 2392C→T in our 192 patients with a high risk of familial breast cancer. 5 breast cancer patients and 1 control exhibited a CHEK2110delC mutation within 990 breast cancer patients and 1016 matched non-cancer controls. Mutations previously demonstrated in PALB2 were not evident in 192 high risk patients.&amp;#x2028; Conclusions&amp;#x2028; We have confirmed the presence of variants in BRIP1 and CHEK2, candidate moderate penetrance genes, in breast cancer patients with a strong family history of breast cancer. This may have implications in clinical practice as our knowledge of these variants expands. The absense of PALB2 variants in patients at high genetic risk points to a low clinical significance. Our findings contribute to a better understanding of inherited breast cancer risk while helping to optimize future screening, therapeutic and prophylactic programs. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3092.
Spectrum of the Breast Lesions With Increased 18F-FDG Uptake on PET/CT
Authors: Aisheng Dong, Yang Wang, Jianping Lu, Changjing Zuo
Journal: Clinical Nuclear Medicine (2016)

Interpretation of F-FDG PET/CT studies in breast is challenging owing to nonspecific FDG uptake in various benign and malignant conditions. Benign conditions include breast changes in pregnancy and lactation, gynecomastia, mastitis, fat necrosis, fibroadenoma, intraductal papilloma, and atypical ductal hyperplasia. Among malignancies, invasive ductal carcinoma and invasive lobular carcinoma are common histological types of breast carcinoma. Rarely, other unusual histological types of breast carcinomas (eg, intraductal papillary carcinoma, invasive micropapillary carcinoma, medullary carcinoma, mucinous carcinoma, and metaplastic carcinoma), lymphoma, and metastasis can be the causes. Knowledge of a wide spectrum of hypermetabolic breast lesions on FDG PET/CT is essential in accurate reading of FDG PET/CT. The purpose of this atlas article is to demonstrate features of various breast lesions encountered at our institution, both benign and malignant, which can result in hypermetabolism on FDG PET/CT imaging.
FACTORES ASOCIADOS CON LA ESTANCIA MEDIA HOSPITALARIA Y MORTALIDAD EN PACIENTES SOMETIDOS A UNA CPRE
Authors: R Diez, A Domínguez, J Espinel, G Rascarachi, V Santiago
Journal: Endoscopy (2010)

Objetivo: Analizar los factores asociados a la estancia media y la supervivencia en los pacientes a que se les realiza una CPRE
Aspirin-Exacerbated Respiratory Disease — New Prime Suspects
Authors: Tanya M. Laidlaw, Joshua A. Boyce
Journal: New England Journal of Medicine (2016)

NSAIDs that inhibit cyclooxygenase-1 can provoke severe asthma and rhinosinusitis with nasal polyps and eosinophil infiltration. Cysteinyl leukotriene generation by the leukotriene C4 synthase pathway may cause the bronchoconstriction, vascular leak, and mucous secretion.
SURG-18IMPACT OF INTRAOPERATIVE MRI ON SURGICAL OUTCOME IN PATIENTS WITH GLIOMAS
Authors: Henri-Arthur Leroy, Christine Delmaire, Emilie Le Rhun, Sabine Caron, Richard Assaker, Jean-Paul Lejeune, Nicolas Reyns
Journal: Neuro-Oncology (2015)

SURG-18. IMPACT OF INTRAOPERATIVE MRI ON SURGICAL OUTCOME IN PATIENTS WITH GLIOMAS Henri-Arthur Leroy1, Christine Delmaire2, Emilie Le Rhun1, Sabine Caron2, Richard Assaker1, Jean-Paul Lejeune1, and Nicolas Reyns1; Lille University Hospital, Department of Neurosurgery, Lille, Nord-Pas de Calais, France; Lille University Hospital, Department of Neuroradiology, Lille, Nord-Pas de Calais, France INTRODUCTION: The management of gliomas is based on a first-line surgical resection when significant tumor reduction can be achieved. Since our institution is equippedwitha1.5T IntraoperativeMRI (IoMRI),weevaluated its impact on the extent of resection of gliomas, clinical outcomes and survival. METHODS: All patients operated on for gliomas using the IoMRI since its installation were systematically included. Functional MRI determined the cerebral dominance. Intraoperative evaluation of resection used a 3D FLAIR /T2orT13D withgadolinium basedonpreoperative tumoraspect, enhancing or not, automatically updating the neuronavigation. We studied clinical data, the course of the surgical procedure (number of MRI control, sequences used, operative time). Postoperative residual tumor volume after early postoperative MRI control (,72 h) wascompared with the preoperativevolume. RESULTS: 55 glial tumors were operated on using IoMRI. 60% of gliomas were “de novo”, 40% were recurrences. Histological analyses reported a majority of grade II and III. Their main location was the frontal lobe (38%), with a consistent group of fronto-temporo-insular tumors. Most patients only had one peroperative MRI control, lasting 39 min in average. If needed the second IoMRI was shorter, 23 min. The average preoperative tumor volume was 32.66 cm, and postoperative volume of 1.11 cm. Complete resection was reached in 70%. Low-grade gliomas required more IoMRI controls than high grade. The use of IoMRI has not been associated with an increased rate of complications (infectious, hemorrhagic). We noticed a temporary increase of neurological deficits during the post-operative week, not found 3 months later. CONCLUSION: IoMRI optimized the removal rate without additional complication despite an extension of the operating time of 1:30 on average. During dissection of critical areas, such as fronto-insular region, IoMRI allowed to readjust neuronavigation, offsetting brainshift and ensuring greateraccuracy for surgical resection. Neuro-Oncology 17:v214–v220, 2015. doi:10.1093/neuonc/nov235.18 Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2015.
Abstract 94: Wnt signaling antagonists are progressively hypermethylated during colorectal neoplastic progression
Authors: Ana-Luisa Silva, Mark J. Arends, Andrew H. Wyllie, Ashraf EK Ibrahim
Journal: Cancer Research (2011)

Abstract Background: Colorectal cancer (CRC) is the third most common type of cancer. The Wnt signaling pathway is known to play an important role in initiation and progression of CRC. Suppression of Wnt antagonists by promoter hypermethylation has been proposed to increase Wnt activity. DNA methylation changes of Wnt antagonists during CRC progression through the preinvasive adenoma stage have not been previously characterized. We analyzed promoter methylation changes of selected Wnt antagonists in a set of synchronous normal, hyperplastic or adenomatous polyps and adenocarcinoma tissue samples obtained from colectomy specimens. Method: We profiled methylation changes in CpG islands associated with the Wnt signaling antagonists DKK1, DKK2, DKK3, WIF1, SFRP1, SFRP2, SFRP4, SFRP5, and SOX17 using pyrosequencing assays. We also examined methylation changes of two members of the β-catenin destruction complex, APC and AXIN2, and two non-antagonist genes (CDH1 and DVL2) involved in Wnt signaling. The sample set included 48 cases comprising matched normal (n=73), hyperplastic polyp (n=9), adenoma (n=42) and adenocarcinoma (n=48) tissue samples. Results: Our samples showed significant widespread hypermethylation changes of a subset of the analyzed Wnt antagonists in the transition from normal to hyperplastic polyp to carcinoma and from normal to adenoma to carcinoma, mostly in an increasing stepwise pattern (p&amp;lt;0.05, Wilcoxon rank sum test). DKK1 showed no significant change during CRC progression, DKK3 did not show significant methylation changes during the hyperplastic polyp to carcinoma stage and SFRP4 was not significantly hypermethylated during adenoma to adenocarcinoma progression. APC was hypermethylated in a small subset of carcinomas, however, these changes were not statistically significant. AXIN2 and the non-antagonist Wnt genes, CDH1 and DVL2 showed consistent normal levels of methylation throughout CRC progression. Conclusion: Wnt antagonists are progressively hypermethylation during CRC neoplastic development. We propose that CpG island hypermethylation of Wnt antagonists could be used as biomarkers for early detection of CRC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 94. doi:10.1158/1538-7445.AM2011-94
Diagnostic Criteria for Nonviable Pregnancy
Authors: Meredith Warden, Courtney A Schreiber, Jody Steinauer
Journal: New England Journal of Medicine (2014)

To the Editor: In their article on diagnostic criteria for nonviable pregnancy early in the first trimester, Doubilet et al. (Oct. 10 issue)1 provide important data for clinicians caring for women with desired pregnancies. However, given that almost half of all U.S. pregnancies are unintended and that half of these end in abortion, it is unreasonable to assume that all pregnancies are desired.2 The first key question when encountering a patient with symptomatic early pregnancy should be, “Is this a desired pregnancy?” If the pregnancy is desired, only then should attention turn to answering the question, “Is there a chance . . .
Swedish Study Helps Usher in a New Treatment Era
Authors: J. Ziegler
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Swedish Study Helps Usher in a New Treatment Era Get access Jan Ziegler Jan Ziegler Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 9, 4 May 1994, Pages 656–657, https://doi.org/10.1093/jnci/86.9.656 Published: 04 May 1994
EUS based strategy for surgical resection of mesenchymal tumors (MTs) of upper gastrointestinal tract
Authors: V Napolitano, G Russo, G Rossetti, G Del Genio, L Brusciano, S Tolone, C Sagnelli
Journal: Endoscopy (2006)

Mesenchymal tumors of upper g.i. tract are often benign but, some of them, as GISTs or GANTs may have a malignant behaviour. Therefore a precise diagnosis would be important for their management and surgical treatment, if needed; but it is very difficult to achieve preoperatively. The aim of the study was to verify if a more detaliled classification of MTs, based on EUS imaging, could improve therapeutic planning. From 2000 to 2005, 259 pts underwent EUS examination for a suspected esophageal, gastric or duodenal submucosal lesion. In 121 pts EUS showed a hypoechoic intramural mass, that represents the basic feature of MTs. According to EUS criteria settled by us, these patients were divided into four groups, corresponding to a specific diagnostic hypothesis. Group 1 (leiomyoma): very low echogenicity (equal to that of the normal proper muscle) and homogeneous internal echo, regular margins, often bordered by a thin echorich line. Group 2 (GIST): low echogenicity, but higher than that of proper muscle and slightly heterogeneous internal echo, regular margins, sometimes with a hypoechoic halo. Group 3 (GIST suspicious of malignancy): echofeatures similar to group 2, but markedly heterogeneous internal echo. Group 4 (malignant MTs): echofeatures similar to group 3, but irregular margins and infiltration of adjacent layers. 38 pts were operated on. Surgical treatment, planned on the basis of EUS diagnosis, ranged from extramucosal enucleation of the tumor to wide resections. Compared with histology, EUS overall accuracy was 76%. Sensitivity and specificity were 87% and 91% for diagnosis of leiomyoma; 100% and 75% for diagnosis of GIST; 69% and 92% for diagnosis of malignant MT. Surgical procedure resulted to be adequate in all but three cases. Although the number of patients is small, criteria we adopted for EUS diagnosis seem to be helpful to plan surgical therapy.
Voluntary and involuntary processes affect the production of verbal and non-verbal signals by the human voice
Authors: Carolyn McGettigan, Sophie Kerttu Scott
Journal: Behavioral and Brain Sciences (2014)

We argue that a comprehensive model of human vocal behaviour must address both voluntary and involuntary aspects of articulate speech and non-verbal vocalizations. Within this, plasticity of vocal output should be acknowledged and explained as part of the mature speech production system.
Traitement endoscopique des complications biliaires du kyste hydatique du foie
Authors: H Seddik, H El Koundi, FZ El Hamdi, A Benkirane
Journal: Endoscopy (2011)

Introduction: Par sa latence clinique, le diagnostic du kyste hydatique du foie est fait le plus souvent au stade de complications, à savoir la fistulisation dans les voies biliaires et la surinfection de la cavité résiduelle. Le développement des techniques d'endoscopie et de radiologie interventionnelle a permis d'améliorer la prise en charge de ses principales complications biliaires.