tbuckley/cabot-search huggingface dataset:
AB0035 Associations between ENOS polymorphisms and susceptibility to systemic lupus erythematosus: A Meta-A
Authors: Y.H. Lee, S.J. Choi, J.D. Ji, G.G. Song
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Genetic factors may play a role in the development of systemic lupus erythematous (SLE), and endothelial nitric oxide synthase (eNOS) polymorphisms have been associated with SLE. <h3>Objectives</h3> The aim of this study was to determine whether eNOS polymorphisms confer susceptibility to SLE and lupus nephritis (LN). <h3>Methods</h3> A meta-analysis was conducted on the associations between the 4b/a, G894T, and C786T polymorphisms of eNOS and SLE and LN using; 1) the allele contrast, 2) the recessive, 3) the dominant, and 4) the additive models. <h3>Results</h3> A total of 8 studies, which included 1297 cases and 1214 controls, were included in the meta-analysis. Meta-analysis showed no association between SLE and the 4b/a polymorphism in all study subjects. Stratification by presence of LN indicated a significant association between the a allele and the aa+ab genotype of the 4b/a polymorphism and LN in SLE patients (OR =2.125, 95% CI =1.289–3.054, p=0.003; OR =2.655, 95% CI =1.509–4.671, p=0.001). No association was found between SLE and the G894T polymorphism using the allelic, recessive, or dominant, or additive models. Meta-analysis of the T786C polymorphism showed a tendency of an association between the TT genotype and SLE (OR =1.220, 95% CI =1.000–1.489, p=0.050), and meta-analysis of the TT vs. CC genotype of the C786T polymorphism in group in H-W equilibrium revealed a significant association between the TT genotype and SLE (OR =1.643, 95% CI =1.021–2.644, p=0.041). <h3>Conclusions</h3> This meta-analysis of published studies shows that the 4b/a polymorphism may be associated with the development of LN, and the C786T polymorphism may be associated with SLE susceptibility. <h3>Disclosure of Interest</h3> None Declared
Characteristics of "erotic" practitioners
Authors: S H Kardener, M Fuller, I N Mensh
Journal: American Journal of Psychiatry (1976)

Using the responses of 460 physicians to a questionnaire survey regarding sexual contact with patients (1), the authors attempt to statistically differentiate two groups--erotic practitioners and nonerotic practitioners. Analysis of data suggests that the freer a physician is with nonerotic contact with patients, the more statistically likely he is to engage in erotic contact.
Effect of Thrombolytic Therapy on Pulmonary-Capillary Blood Volume in Patients with Pulmonary Embolism
Authors: G. V. R. K. Sharma, Virginia A. Burleson, Arthur A. Sasahara, Barbara Roggeveen, Nazarene Mondello, Helen Guilford
Journal: New England Journal of Medicine (1980)

To compare the effects of heparin thrombolytic agents in pulmonary thromboembolic disease, we randomly assigned 40 patients with pulmonary emboli but without other clinical cardiopulmonary disease either to heparin followed by oral anticoagulants (21 patients) or to urokinse or streptokinase followed by heparin and then by oral anticoagulants (19 patients). The effects on pulmonary-capillary blood volume and diffusing capacity were compared at two weeks and at one year. The pulmonary-capillary blood volume (in milliliters per square meter of body-surface area) was abnormally low (30 +/- 2.4) [+/- S.E.]; normal, 47 +/- 1.5) in the heparin-treated group at two weeks and remained unchanged at one year. In contrast, it was normal (45 +/- 2.5) in the group receiving thrombolytic agents, both at two weeks and at one year (P < 0.001). The pulmonary diffusing capacity was reduced to 69% of the predicted value in the heparin group at two weeks and 72% at one year, whereas it was 85% of the predicted value in the thrombolytic group at two weeks and 93% at one year (P < 0.001). These results indicate that thrombolytic agents allow more complete resolution of thromboemboli than do heparin and anticoagulants and that they improve capillary perfusion and diffusion.
Clinical Healing Two to Six Years after Poststreptococcal Glomerulonephritis in Trinidad
Authors: Elizabeth V. Potter, Stella Abidh, A. Richey Sharrett, Emma G. Burt, Mauri Svartman, John F. Finklea, Theo Poon-King, David P. Earle
Journal: New England Journal of Medicine (1978)

To determine the incidence of chronic nephritis after poststreptococcal acute glomerulonephritis in Trinidad, 760 patients (41 adult) were examined two to six years after recovery from the illness, 344 being studied twice (four and six years). Only 1.8 per cent had persistent urine abnormalities on their last follow-up examination, and another 8.0 per cent had abnormalities that were transient or occurred only after the patient had assumed the lordotic position. In 1.4 per cent hypertension was present, whereas only one had azotemia. Both persistent urine abnormalities and hypertension increased in prevalence with age at onset of prior poststreptococcal glomerulonephritis but did not vary between sexes, races or epidemic versus endemic forms. Half the urine abnormalities present four years after recovery were absent two years later. Thus, poststreptococcal acute glomerulonephritis appears to have a low incidence of chronicity in Trinidad, with continuing resolution for more than four years.
FRI0290 Effect of Treatment with Methotrexate and Tnf-Alpha Inhibitors on Insulin Resistance in Early Rheumatoid Arthritis: Table 1
Authors: Y. Gorbunova, L. Kondratyeva, T. Popkova, D. Novikova, A. Novikov, M. Cherkasova, D. Olisaeva, O. Fomicheva, E. Luchihina, E. Alexandrova, E. Nasonov
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> The relationship between insulin resistance (IR) and inflammation in rheumatoid arthritis (RA) is poorly studied. Assume that an effective anti-inflammatory therapy may affect the IR. As IR markers currently used HOMA-IR index and the ratio of leptin/adiponectin (L/A). <h3>Objectives</h3> Evaluate the effect of combined treatment with methotrexate (MTX) and TNF-alpha inhibitors on IR in early RA. <h3>Methods</h3> In the study included 22 patients (15 female, 7 male) with RA eligible ACR, EULAR 2010, never receiving glucocorticoids and disease-modifying anti-rheumatic drugs. Average age of the patients - 57 [54, 60] years, mean duration of disease - 8 [6.0, 15.0] months, mean DAS28 - 5,9 [5,3; 6,9]. All patients were positive for RF and anti-CCP. The control group consisted of 30 subjects (23 women, 7 men) without rheumatic disease, matched by sex, age and body mass index (BMI) with RA patients. Baseline and after 24 weeks of observation, patients were evaluated by: RA activity (indices DAS, SDAI, CDAI), the index HOMA-IR, adiponectin and leptin concentration, the ratio of leptin/adiponectin (L/A). Level of adipokines was also examined in the control group by ELISA. <h3>Results</h3> At study entry adiponectin levels was higher in RA patients than in controls (20.0 [17.8, 34.0] vs 8,6 [5,6;12,2] ng/ml); leptin (25.4 [11.0, 32.0] vs 36,8 [19,0;46,2] ng/ml) and the ratio L/A (1.49 [0.2;1.9] vs 5,31[2,7;6,8]) is lower in RA patients than in controls vs (p&lt;0.05 respectively). All patients with RA was assigned MTX, and after 12 weeks - an inhibitors of TNF-alpha (19 patients - adalimumab, 3 - certolizumab pegol). After 24 weeks of treatment decreased DAS28 (p=0,0001), SDAI (p=0,0006), CDAI (p=0,0003) and adiponectin levels (p=0,008). Leptin levels (p=0,005) and the ratio L/A (p=0,01) significantly increased, HOMA-IR did not change (p=0,2) (table1). <h3>Conclusions</h3> The combination therapy of RA antiinflammatory (inhibitors of TNF-alpha, methotrexate) for 24 weeks decreases the activity of RA, but does not improve the performance of IR. The ratio L/A is preferably use at an early stage of the RA for the assessment of IR. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5239
SAT0169 Ultrasound Evaluation of Ankle Joint in Rheumatoid Arthritis Patients with Clinical Remission and Low Disease Activity
Authors: A.E. Musetescu, I. Cojocaru-Gofita, F. Vreju, M. Florea, A. Rosu, P. Ciurea
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) who have achieved clinical remission (CR) or low disease activity (LDA) may have synovitis detectable by ultrasound (US) and continue to get joint distruction. Despite an essential role for RA patients stability and mobility, the ankle joints are frequently omitted in activity scoring systems including DAS 28. Consequently patients with DAS 28 CR or LDA frequently maintain a symptomatic ankle and only few studies have assessed pathologies detected by ultrasonography in these circumstances. <h3>Objectives</h3> The main purpose of the study was to evaluate the ankle joint involvement through power Doppler ultrasound in patients with RA who have achieved CR or LDA according to DAS 28 EULAR criteria. <h3>Methods</h3> 50 consecutive RA patients (ACR/EULAR classification criteria 2010) who have achieved CR or LDA were reviewed. Patients underwent DAS28 assessment and US of the ankle joints. Synovitis was detected by power Doppler (PDUS) and scored on a 0–3 semi-quantitative scale. A total number of 100 ankle joints were examined using MSUS. Talonavicular, intertarsal- and tarso-metatarsal joints as well as flexor and extensor tendons were investigated. <h3>Results</h3> Ankle pain was recorded in 31 patients while 19 patients were asymptomatic. Pathology detected was arthritis of the tibiotalar and/or talonavicular joint in 72% of the patients (36 out of 50), followed by tenosynovitis of the flexor tendons in 56% of the patients (28 out of 50). Gray scale findings were observed in 90.3% of the symptomatic patients (28/31) as well as in 53% of the asymptomatic patients (10/19) (p&lt;0.01). PDUS activity was higher in symptomatic patients - 35% (11/31) compared to 21% in asymptomatic patients (4/19) (p&lt;0.01). 10 patients (43%) in CR presented gray scale arthritis and tenosynovitis and 13% PD activity while 26 patients (93%) in LDA were positive for gray scale arthritis and tenosynovitis and 43% patients for PD signal. <h3>Conclusions</h3> Ultrasonographic Doppler imaging reflects disease activity even in patients with low activity or in remission.Ankle joint is frequently involved according to ultrasound evaluation in patients with RA in DAS 28 LDA or CR. Most frequent pathologies detected by MSUS were arthritis of the tibiotalar and talonavicular joint, followed by tenosynovitis of the flexor tendons. Pathologic findings are also very common in asymptomatic patients with RA, whereas PDUS activity is predominately observed in symptomatic patients. Ankle joint should be more closely monitored for pathological findings in patients with LDA or CR as it frequently represents a source of pain, instability and disability in patients with RA. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5946
Physical Activity and Reduced Occurrence of Non-Insulin-Dependent Diabetes Mellitus
Authors: Susan P. Helmrich, David R. Ragland, Rita W. Leung, Ralph S. Paffenbarger
Journal: New England Journal of Medicine (1991)

Physical activity is recommended by physicians to patients with non-insulin-dependent diabetes mellitus (NIDDM), because it increases sensitivity to insulin. Whether physical activity is effective in preventing this disease is not known.
Intense Accumulation of Ga-67 Citrate in Solid and Cystic Tumors of the Pancreas
Authors: Tamaki Ichikawa, Hiroki Takenaka, Wakako Yamamoto, Hideharu Sugimoto, Osamu Tanaka
Journal: Clinical Nuclear Medicine (2002)

ICHIKAWA, TAMAKI M.D.*; TAKENAKA, HIROKI M.D.*; YAMAMOTO, WAKAKO M.D.†; SUGIMOTO, HIDEHARU M.D.†; TANAKA, OSAMU M.D.‡ Author Information
Case 11-1994
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, David J. Wyler, Anthony R. Mattia
Journal: New England Journal of Medicine (1994)

Presentation of CaseA 35-year-old man, a native of Ethiopia, was admitted to the hospital because of fever, chills, and splenomegaly.Twelve years before admission he had immigrated to the Sudan, where he remained for 10 years, employed as a tailor. Eight years after arriving in the Sudan he became ill with fever, jaundice, and abdominal pain. Lymphadenopathy and prominent splenomegaly were found. The hemoglobin level was 11 g per deciliter, the white-cell count 7000 per cubic millimeter, and the erythrocyte sedimentation rate 100 mm per hour. Evidence of giardia, ascaris, and Entamoeba histolytica infestation was found in stool specimens, . . .
Acute Phosphorus Poisoning
Authors: T. E. Chretien
Journal: New England Journal of Medicine (1945)

AT ONE time phosphorus was a common poison owing to the use of yellow phosphorus in match tips. This practice is now prohibited by law, and as a result the number of deaths from phosphorus poisoning has been greatly reduced.1 Phosphorus is, however, still used in various forms of rat and roach pastes that are easily available to the pica of some children in certain environments. Several deaths of children have been reported from eating fireworks, especially the so-called "spit devil" variety.2 The majority of cases of phosphorus poisoning in adults are the result of suicidal attempts, some form of . . .
Words to the wise: Words that count
Authors: G. Hutchison
Journal: BMJ (1998)

It is possible to suffer simultaneously from acalculia and renal calculi, which is an odd state of affairs, on reflection. Both terms come from the Latin calculus , a small stone: a word that is formed by adding a diminutive ending to calx, the Latin word for chalk or limestone. Calx gives us our words calcium and calcine ; but the os calcis , you may note, is not a particularly chalky bone. For reasons unknown, the Romans also used calx to mean “heel,” and our word recalcitrant derives from that usage: it suggests a person who is liable to kick with their heels, like a mule.

But we should return to the little stones: they can be used to calculate …
P596The complexity of coronary artery disease influences number and function of stem cells in the bone marrow
Authors: E Nollet, D De Bock, IR Rodrigus, VY Hoymans, CJ Vrints, EM Van Craenenbroeck
Journal: Cardiovascular Research (2014)

Purpose. Despite the observed therapeutic benefits of autologous bone marrow (BM) cell transplantation in patients with ischemic heart disease, the efficacy of this approach could be hampered by intrinsic BM dysfunction. We investigated whether BM cellularity and function is affected by the severity of coronary artery disease (CAD). Methods. 23 CAD patients, undergoing coronary artery bypass surgery (age 62±9 yrs; LVEF 52±15%), were stratified according to their Syntax score (≤ and > 13), which is used to assess complexity of coronary lesions. BM samples were obtained peri-operatively. In vitro functional analysis of isolated BM-derived mononuclear cells (MNC) included (i) migratory capacity towards SDF-1α and VEGF, (ii) number of granulocyte-macrophage colony forming units (GM-CFU) and (iii) burst forming units erythroid (BFU-E). Numbers of hematopoietic stem cells (HSC, CD45dimCD34+SSClow) and endothelial progenitor cells (EPC, CD45dimCD34+KDR+) were quantified by flow cytometry. Results. Patients with Syntax score >13 showed a significantly impaired migratory capacity of BM-MNC (34.9±8.2% vs. 26.9±7.7%; p=0.03) and a reduced number of EPC (2233±1944 EPC/106 BM-MNC vs. 472±464 EPC/106 BM-MNC; p=0.01) compared to patients with Syntax score ≤ 13. GM-CFU, BFU-E and HSC numbers did not differ between groups. An inverse correlation was found between age and the number of GM-CFU (r= -0.487; p=0.03) and BFU-E (r= -0.505; p=0.02). Furthermore, our data revealed a relation between reduced renal function (eGFR, 77.4±18.0 ml/min) and number of HSC (r=0.433; p=0.039) and EPC (r=0.466; p=0.029). Conclusions. Migratory capacity of BM-MNC is impaired in patients with severe CAD, which could lead to a reduced therapeutic efficacy of autologous stem cell therapy in this patient group. In addition, EPC number decreases as the complexity of CAD increases. Not only CAD complexity, but also age and renal function are identified as influencing factors on the bone marrow function and stem cell populations.
AB0971 Chondroprotective effect of sulforaphane and PLGA-based delivery system
Authors: G.-I. Im, J.-Y. Ko, Y.-J. Choi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Sulforaphane [SFN; 1-isothiocyanato-4-(methylsulphinyl)-butane], a naturally occurring isothiocyanates (ITC) obtained through the consumption of broccoli, is one of the most potent inducers of the phase 2 enzymes implicated in carcinogen detoxification [1]. In addition to its chemopreventive activity, SFN inducers have been recently found to have anti-inflammatory activity [2]. Recent study suggests that SFN suppresses matrix metalloproteinase (MMP) production from articular chondrocytes stimulated with either IL-1 or TNF-a and that SFN inhibits NF-KB and JNK activation in pro-inflammatory cytokine-stimulated articular chondrocytes [3]. <h3>Objectives</h3> In this study, chondrocytes derived from OA pateints were used for in vitro model to investigate the protective effect of SFN on inflammatory damage induced by lipopolysaccharide (LPS). In addition, we devised SFN delivery system using biodegradable poly(lactide-<i>co</i>-glycolide) (PLGA) and demonstrated that the system has enduring chondroprotective effect on inflammatory damage induced by LPS. <h3>Methods</h3> Articular cartilages were obtained from knee OA patients and were cultured in monolayers. The cells were pretreated with 1 mg/ml LPS for 6 h and subsequently with 0–20 mM SFN for 18 h. Effect of PLGA-based SFN delivery system on cartilage protection was examined by the experiments using transwell insert. The cell cytotoxicity was determined by MTT assay and the expression of COX-2, ADMATS-5, MMP-2 and TIMP-2 was evaluated by western blotting and RT-PCR. <h3>Results</h3> SFN was not toxic to chondrocytes upto the dose of 5 mM. However, SFN at 5 mM significantly inhibited mRNA expression and protein level of ADAMTS-5 and MMP-2 without cytotoxicity in chondrocytes. In addition, slow release SFN delivery system (SFN-PLGA) inhibited mRNA and protein level of COX-2, ADAMTS-5 and MMP-2 by LPS in chondrocytes. TIMP(tisuue inhibitor of MMPs)-2 mRNA expression and protein level were increased by SFN-PLGA system. <h3>Conclusions</h3> These results indicated that SFN has chondroprotective effect on inflammatory damage induced by LPS. PLGA-based delivery system may provide a effective tool for the controlled release of SFN. <b>Acknowledgements:</b> This work was supported by a grant from the Korea National Research Foundation of Korea (Grant No 2011-0027473). <h3>References</h3> Brooks JD, Paton VG, Vidanes G. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Cancer Epidem Biomarker Prev 2001; 10:949–54. Dinkova-Kostova AT, Liby KT, Stephenson KK et al. Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress. Proc Natl Acad Sci USA 2005;102:4584–9. Kim HA, Yeo Y, Kim WU, Kim S. Phase 2 enzyme inducer sulphoraphane blocks matrix metalloproteinase production in articular chondrocytes. Rheumatology 2009;48:932-8. <h3>Disclosure of Interest</h3> None Declared
Influence of Pravastatin, a Specific Inhibitor of HMG-CoA Reductase, on Hepatic Metabolism of Cholesterol
Authors: Eva Reihnér, Mats Rudling, Dagny Ståhlberg, Lars Berglund, Staffan Ewerth, Ingemar Björkhem, Kurt Einarsson, Bo Angelin
Journal: New England Journal of Medicine (1990)

Inhibitors of the rate-limiting enzyme of cholesterol biosynthesis, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are now used frequently to treat hypercholesterolemia. We studied the effects of specific inhibition of cholesterol synthesis by one of these agents (pravastatin) on the hepatic metabolism of cholesterol in patients with gallstone disease who were scheduled to undergo cholecystectomy.
Abstract LB-330: Endogenous T cell responses to lung adenocarcinoma neoantigens delay malignant tumor progression
Authors: Michel DuPage, Ann F. Cheung, Claire Mazumdar, Monte M. Winslow, Roderick T. Bronson, Denise Crowley, Tyler Jacks
Journal: Cancer Research (2010)

Abstract Neoantigens derived from somatic mutations in tumors may provide a critical link between the adaptive immune system and cancer. However, it has been difficult to properly recapitulate immune responses against tumor neoantigens in models of the human disease. Here we describe a novel system to induce the expression of potent neoantigens in a genetically engineered mouse model of lung cancer. We show that endogenous T cells respond to and infiltrate tumors, resulting in a significant delay in malignant progression. However, despite continued neoantigen expression, T cell infiltration does not persist and tumors ultimately escape immune attack. In contrast, transplantation of cell lines derived from lung tumors that express neoantigens, even those that have escaped the immune system in their autochthonous setting, or prophylactic vaccination against autochthonous tumors, evoke robust T cell responses that either lead to rapid tumor eradication or selection of tumors that lose neoantigen expression. These results support clinical data that suggest a role for the immune system in cancer suppression rather than prevention. This model provides a valuable system for the optimization of immune therapies that can eradicate human cancers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-330.
CARDIAC CATHETERIZATION AND PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH END STAGE LIVER DISEASE
Authors: Nabil Noureddin, Suchit Bhutani, Jonathan Tobis, Christopher Low, Yakov Mamzhi, William Suh, Henry Honda, Babak Azarbal, Randolph Steadman, Christopher Wray, Ronald Busuttil
Journal: Journal of the American College of Cardiology (2015)
Third-Party Reimbursement Issues During a Phase 1 Trial of Interleukin-2
Authors: N. J. VOGELZANG, J. M. RICHARDS
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Third-Party Reimbursement Issues During a Phase 1 Trial of Interleukin-2 Get access NICHOLAS J. VOGELZANG, NICHOLAS J. VOGELZANG Hematology/Oncology University of Chicago Medical CenterBox 420 Chicago, IL 60637 Search for other works by this author on: Oxford Academic PubMed Google Scholar JON M. RICHARDS JON M. RICHARDS Hematology/Oncology University of Chicago Medical CenterBox 420 Chicago, IL 60637 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 7, 5 April 1989, Pages 544–545, https://doi.org/10.1093/jnci/81.7.544 Published: 05 April 1989