tbuckley/cabot-search huggingface dataset:
Abstract 3591: The role of T-cell protein tyrosine phosphatase (TC-PTP) in UVB-induced epidermal cell proliferation and survival.
Authors: Young S. Lee, Jun W. Shin, Liza D. Morales, Thomas J. Slaga, Dae J. Kim
Journal: Cancer Research (2013)

Abstract Ultraviolet (UV) radiation is the primary cause of human skin cancer. Signal transducer and activator of transcription 3 (Stat3) is one of the key regulators of epidermal cell survival and proliferation during the development of UV-induced skin cancer. We have previously shown that T-cell protein tyrosine phosphatase (TC-PTP) contributes to the rapid dephosphorylation /deactivation of Stat3 in response to UVB irradiation in keratinocytes. In the current work, we investigated the functional role of TC-PTP in keratinocyte survival and proliferation following UVB exposure. Knockdown of TC-PTP in mouse keratinocytes using siRNA significantly reduced apoptosis following UVB irradiation in comparison with control keratinocytes as evidenced by the decreased levels of activated caspase-3 and PARP cleavage. This reduction corresponded with an increased level of phososphorylated Stat3 in TC-PTP-deficient keratinocytes. Knockdown of TC-PTP in keratinocytes also significantly increased cell proliferation following UVB irradiation compared with control keratinocytes. Similar with these results, overexpression of TC-PTP in keratinocytes significantly increased apoptosis and decreased cell proliferation in response to UVB irradiation compared with control keratinocytes, which corresponded with a decreased level of phosphorylated Stat3. Further studies using TC-PTP-deficient keratinocyte cell lines showed that cell viability was increased in TC-PTP-deficient cells following UVB irradiation. Treatment of TC-PTP-deficient keratinocytes with specific Stat3 inhibitor, STA21 significantly reduced cell viability, upon UVB exposure in comparison with untreated TC-PTP-deficient keratinocytes, which suggests that the effect of TC-PTP on cell viability is mediated by Stat3 dephosphorylation. Combined, our results indicated that TC-PTP plays an important role in the regulation of keratinocyte proliferation and survival after UVB exposure via modulation of Stat3 signaling. Furthermore, these results suggest that TC-PTP may be a novel potential target for the prevention of UVB-induced skin cancer. Citation Format: Young S. Lee, Jun W. Shin, Liza D. Morales, Thomas J. Slaga, Dae J. Kim. The role of T-cell protein tyrosine phosphatase (TC-PTP) in UVB-induced epidermal cell proliferation and survival. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3591. doi:10.1158/1538-7445.AM2013-3591
Recent infection testing algorithm (RITA) applied to new HIV diagnoses in England, Wales and Northern Ireland, 2009 to 2011
Authors: A Aghaizu, G Murphy, J Tosswill, D DeAngelis, A Charlett, O  N Gill, H Ward, S Lattimore, R D Simmons, V Delpech
Journal: Eurosurveillance (2014)

In 2009, Public Health England (PHE) introduced the routine application of a recent infection testing algorithm (RITA) to new HIV diagnoses, where a positive RITA result indicates likely acquisition of infection in the previous six months. Laboratories submit serum specimens to PHE for testing using the HIV 1/2gO AxSYM assay modified for the determination of HIV antibody avidity. Results are classified according to avidity index and data on CD₄ count, antiretroviral treatment and the presence of an AIDS-defining illness. Between 2009 and 2011, 38.4% (6,966/18,134) of new HIV diagnoses in England, Wales and Northern Ireland were tested. Demographic characteristics of those tested were similar to all persons with diagnosed HIV. Overall, recent infection was 14.7% (1,022/6,966) and higher among men who have sex with men (MSM) (22.3%, 720/3,223) compared with heterosexual men and women (7.8%, 247/3,164). Higher proportions were among persons aged 15-24 years compared with those ≥50 years (MSM 31.2% (139/445) vs 13.6% (42/308); heterosexual men and women 17.3% (43/249) vs 6.2% (31/501)). Among heterosexual men and women, black Africans were least likely to have recent infection compared with whites (4.8%, 90/1,892 vs 13.3%, 97/728; adjusted odds ratio: 0.6; 95% CI: 0.4-0.9). Our results indicate evidence of ongoing HIV transmission during the study period, particularly among MSM.
NC-11 * COMPUTERIZED TESTING IN PATIENTS WITH MENINGIOMAS: IMPROVEMENT OF COGNITIVE FUNCTIONING AFTER SURGERY
Authors: I. Meskal, K. Gehring, S. van der Linden, G.-J. Rutten, M. Sitskoorn
Journal: Neuro-Oncology (2014)

Cognitive dysfunction is common in patients with primary brain tumors, and may have a major impact on activities of daily living and on quality of life. This is the first prospective study that investigated the incidence and severity of cognitive dysfunction in meningioma patients before and after surgery, and the change in dysfunction over time, both at group and individual patient level. Sixty-eight meningioma patients were neuropsychologically tested one day before brain surgery. Sixty-two patients were followed up 3 months after surgery. All patients were assessed with a brief (30 minutes) computerized screening battery of neuropsychological tests (i.e., CNS Vital Signs). Pre-and postoperatively, meningioma patients demonstrated significantly lower scores in all cognitive domains; memory, psychomotor speed, reaction time, complex attention, cognitive flexibility, processing speed, and executive functioning, in comparison with normative data. Preoperatively, 47 out of 68 patients (69%) scored low or very low in one or more cognitive domains. Postoperatively 27 out of 62 patients (44%) scored within this range. Test performance improved in all cognitive domains postoperatively, with the exception of psychomotor speed and reaction time. In line with previous studies with conventional neuropsychological tests, meningioma patients are faced with cognitive dysfunction in several cognitive domains both pre- and postoperatively. However, a large proportion of patients shows postoperative improvement in cognitive functioning. Longer-term follow-up is recommended to identify potential predictors of cognitive improvement after surgery. Diagnosis and treatment of these cognitive deficits will improve outcomes and quality of life in meningioma patients.
1342 LIVER INJURY FOLLOWING ANTI-TNF-ALPHA PEPTIDES: EXPERIENCE OF THE US DRUG-INDUCED LIVER INJURY NETWORK (DILIN) AND CRITICAL REVIEW OF PUBLISHED REPORTS
Authors: M. Ghabril, H. Bonkovsky, C. Kum, T. Davern, D. Kleiner, J. Serrano, P. Hayashi, R. Fontana, M. Bonacini
Journal: Journal of Hepatology (2012)
Choosing Benefits while Balancing Risks
Authors: Michael F. Greene, Jeffrey L. Ecker
Journal: New England Journal of Medicine (2015)

Until the 20th century, home was where most births took place. By the second half of that century, hospital birth had become the norm in most Western countries. With this change came the “medicalization” of birth, as hospitals introduced interventions to reduce the risks inherent to childbirth that could not be performed in the home setting. Many of these interventions were beneficial, even lifesaving, for the mother or baby, but some, often judged in retrospect, seemed unnecessary. The occasional performance of a cesarean delivery for a fetus thought to have hypoxemia and acidosis followed by the delivery of an entirely . . .
COMPLETE VERSUS CULPRIT-ONLY REVASCULARIZATION IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION AND MULTIVESSEL DISEASE: A META-ANALYSIS OF RANDOMIZED TRIALS
Authors: Jae-Sik Jang, Ho-Cheol Shin, Han-Young Jin, Jeong-Sook Seo, Tae-Hyun Yang, Dae-Kyeong Kim, Dong-Soo Kim
Journal: Journal of the American College of Cardiology (2016)
Combined Treatment Substantially Improves outllok for Rectal Cancer Patients
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Combined Treatment Substantially Improves outllok for Rectal Cancer Patients Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 6, 20 March 1991, Pages 386–387, https://doi.org/10.1093/jnci/83.6.386 Published: 20 March 1991
Ranibizumab and Bevacizumab for AMD
Authors: C M Gemmy Cheung, Tien Y Wong
Journal: New England Journal of Medicine (2011)

n engl j med 365;23 nejm.org december 8, 2011 2237 developed during the study, only 44 had macrolide resistance (41%) (P<0.001). In my opinion, this is the correct method to evaluate resistance to macrolides because it compares the subjects of the two groups in whom colonization developed during the study period and not the whole group, as suggested by Hahn. Adequate data on resistance from the whole group were not available for comparison. I strongly believe that macrolide resistance is an issue and should be taken into account, especially when treating a subsequent acute exacerbation of COPD.
CT Opacity in the Lungs Was Preceded by Increased MDP Activity on Bone Scintigraphy
Authors: Le Song, Weifang Zhang, Yanyan Zhang
Journal: Clinical Nuclear Medicine (2014)

Elevated 99mTc-methylene diphosphonate (MDP) uptake in the left lung was demonstrated in a 41-year-old man with chronic lymphocytic leukemia. Lung infection was considered because the patient also had fever and pancytopenia. However, the thoracic CT performed the next day did not reveal abnormality which could explain the cause of left lung MDP activity. The repeated thoracic CTs weeks later demonstrated multiple ground-glass opacity in the left lung.
PERSISTENT INCREASE IN BLOOD PRESSURE FOLLOWING RENAL NERVE STIMULATION IN ACCESSORY RENAL ARTERIES AFTER SYMPATHETIC RENAL DENERVATION
Authors: Arif Elvan, Mark de Jong, Annemiek Hoogerwaard, Pim Gal, Ahmet Adiyaman, Jaap Jan Smit, Peter Delnoy, Anand Ramdat Misier, Boudewijn van Hasselt, Jan-Evert Heeg, Jean-Benoitle Polain de Waroux, Elizabeth Lau, Jan Staessen, Alexandre Persu
Journal: Journal of the American College of Cardiology (2016)
Laparoendoscopic mediastinal vacuum therapy of a gastric perforation through the diaphragm
Authors: A. Fischer, P. Baier, U. Hopt, H. Richter-Schrag
Journal: Endoscopy (2011)

Endoscopically guided endoluminal vacuum therapy using polyurethane sponges has become an established method for treating rectal anastomotic leaks [1] and is now increasingly also used in the upper gastrointestinal tract [2] [3] [4]. We report on transhiatal placement of an Endo-Sponge (Braun Medical, Melsungen, Germany) into the mediastinum using the Gastrotrokar described in an earlier paper [5].
Impact of NHS deficits on patient safety is a resigning issue for Hunt, says head of King’s Fund
Authors: Zosia Kmietowicz
Journal: BMJ (2016)

England’s health secretary, Jeremy Hunt, should consider resigning because the financial pressures on the NHS are putting patient safety at risk, a leading health policy adviser has said.

Chris Ham, former government health adviser and the head of the King’s Fund think tank, said in an article in the Guardian that Hunt should examine his conscience about whether the improvements in patient safety he instigated can be realised in the NHS’s current financial climate.1

As most trusts are running large deficits, many are looking to cut staff to reduce spending, …
Reduction in Late Mortality among 5-Year Survivors of Childhood Cancer
Authors: Gregory T. Armstrong, Yan Chen, Yutaka Yasui, Wendy Leisenring, Todd M. Gibson, Ann C. Mertens, Marilyn Stovall, Kevin C. Oeffinger, Smita Bhatia, Kevin R. Krull, Paul C. Nathan, Joseph P. Neglia, Daniel M. Green, Melissa M. Hudson, Leslie L. Robison
Journal: New England Journal of Medicine (2016)

Among patients in whom childhood cancer was diagnosed in the 1970s and 1980s, 18% of those who survived for 5 years died within the subsequent 25 years. In recent decades, cancer treatments have been modified with the goal of reducing life-threatening late effects.
BEHAVIORAL SIGNIFICANCE OF FRONTAL HYPOPERFUSION IN ALZHEIMERʼS DEMENTIA: XE-133 RCBF VS. HMPAO.
Authors: K Garrett, I Mena, S Read, J Villanueva-Meyer, J Kuperus, B Miller
Journal: Clinical Nuclear Medicine (1988)

Garrett, K; Mena, I; Read, S; Villanueva-Meyer, J; Kuperus, J; Miller, B Author Information
Case 19-2002
Authors: Trevor J.I. McGill, Chin-Lee Wu
Journal: New England Journal of Medicine (2002)

Presentation of CaseA 13-year-old girl was admitted to the Massachusetts Eye and Ear Infirmary because of a mass in the left parotid gland.The patient had been well until four or five months earlier, when a lump in the left side of her neck was first discovered. Seven years earlier, because of recurrent bouts of pharyngotonsillitis and otitis media, an adenotonsillectomy had been performed, and bilateral tympanostomy tubes had been inserted; the infections subsequently ceased. There was an adult cat in her home. She had not had dyspnea, dysphagia, odynophagia, hoarseness, or hemoptysis.Twelve weeks before admission and shortly . . .
"Cancer defeated": not if, but when--introducing the Biology of Neoplasia series.
Authors: S A Cannistra
Journal: Journal of Clinical Oncology (1997)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1997.15.11.3297 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9363857 "Cancer defeated": not if, but when--introducing the Biology of Neoplasia series. S A CannistraxS A CannistraSearch for articles by this author https://doi.org/10.1200/JCO.1997.15.11.3297 PDF ""Cancer defeated": not if, but when--introducing the Biology of Neoplasia series.." Journal of Clinical Oncology, 15(11), pp. 3297–3298© 1997 by American Society of Clinical Oncology
Breast cancer in the elderly: histoclinial features and phenotypical characterization on tissue microarrays (TMA).
Authors: EA Jauffret, J Boher, B Esterni, F Rousseau, J Jacquemier, P Viens
Journal: Cancer Research (2009)

Abstract Abstract #6079 Most breast cancer patients are diagnosed over the age of 65 years, and older cancer patients represent an increasing major public health problem. Research efforts are mainly focused on younger patients and the elderlies are initially excluded from most clinical trials. Improving kwnoledge related to elderly breast caner is urgently needed.734 patients over the age of 70 years out of the 4503 treated in our institution for primary breast cancer from 1975 to 2006 were studied. Pathological data revealed 716 (97.5%) invasive breast cancers, and 633 (88.5%) of ductal type including only 31 (8%) with predominant ductal in situ component. Lobular and mucinous carcinomas were present in11.5 and 3.5%.The tumors were mostly medium size (pT2); displayed no differences in lymph node involvement compared to younger patients and were treated by surgery (680, 93%) with 338 (50%)mastectomy, and with chemotherapy in only 22% (vs 48% in younger). Compared to youngers, tumors were mostly grade II (47%) and displayed less grade III ,estrogen receptors were expressed in 73% and tumors were less proliferative as assed on KI67/Mib1 expression (28 vs 38% positive &amp;lt;70 years) . Phenotypic characterization was done on Tissue-microarrays containing 305 spotted breast samples from patients over the age of 70 for 28 differents markers corresponding to different pathways : adhesion molecules (E-cadherin, p-cadherin, b-catenin), cell cyle and mitosis (fox a1, Ki67, p53, p27 ), differentiation markers (luminal CK8/18, basal/mesenchymal CAV1 &amp;2, CK5/6, CK14, moesin, S100A9, SMA, vimentin, and stem cell markers ALDH1 and CD44), hormonal (hormonal and androgen receptors, bcl2, gata3), tyrosine kinases (ERBB2, EGFR), angiogenesis (angiogenin, CD146,VEGF) pathways. Compared to younger, no marker was significantly different in patients older than 70, except for hormonal pathway (a tendancy to be more positive). Nevertheless, specific survival and metastasis free survival (considering chemotherapy) revealed a worst outcome for older patients. Cox 's univariate model revealed claasical prognostic factors (hormonal pathway,ERBB2, EGFR, Mib1/Ki67) but did not highlight specific pathways. In conclusion, breast cancer in the Elderly is an heterogenic group that display less aggressive histo clincal features, a little more ER-phenotype with less proliferation but an adverse outcome. Specific factors remains to be discover to better treat these patients. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6079.
A Preliminary Trial of Lamivudine for Chronic Hepatitis B Infection
Authors: Jules L. Dienstag, Robert P. Perrillo, Eugene R. Schiff, Maria Bartholomew, Catherine Vicary, Marc Rubin
Journal: New England Journal of Medicine (1995)

Better treatments for chronic hepatitis B are needed. Lamivudine, the (-)enantiomer of 3'-thiacytidine, is a potent inhibitor of hepatitis B virus (HBV).
Reply to eLetter by Feldtkeller<i>et al</i>
Authors: Jan Sørensen, Merete Lund Hetland
Journal: Annals of the Rheumatic Diseases (2014)

Thank you to Drs Feldtkeller and Rudwaleit 1 for your interest in and comments on our paper. 2n the study, which was based on a large number of patients, we investigated the time between symptom onset and diagnosis during the last 10 years.Our analysis was presented at the European League Against Rheumatism 2013 before a large audience and subsequently the paper was scrutinised by three independent reviewers, who had no comments on the choice of method.In the paper, and in the subsequent letter, we discussed and acknowledged a number of potential methodological challenges in an observational setting like this, including the risk of right censorship. 2 3 Based on your comments, however, we acknowledge that this bias arising from patients who have symptoms, but not yet have been diagnosed and, therefore, not included in the data set, may have a larger impact than we understood at the time when the paper was written.
Prevention of Thrombosis in Patients on Hemodialysis by Low-Dose Aspirin
Authors: Herschel R. Harter, John W. Burch, Philip W. Majerus, Nancy Stanford, James A. Delmez, Charles B. Anderson, Carol A. Weerts
Journal: New England Journal of Medicine (1979)

Since platelet cyclo-oxygenase is much more sensitive to inactivation by aspirin than is the enzyme in the arterial wall and low doses of aspirin may prevent thrombosis by blocking thromboxane synthesis, we conducted a randomized, double-blind trial of aspirin (160 mg per day) vs. placebo in 44 patients on chronic hemodialysis. The study was continued until there were 24 patients with thrombi and both groups had been under observation for a mean of nearly five months. Thrombi occurred in 18 of 25 (72 per cent) of patients given placebo and 16 of 19 (32 per cent) of those given aspirin (P less than 0.01). The incidence of thrombosis was reduced from 0.46 thrombi per patient month in the placebo group to 0.16 thrombi per patient month in the aspirin group (p less than 0.005). A dose of 160 mg of aspirin per day is an effective, nontoxic antithrombotic regimen in patients on hemodialysis.
SAT0548 Impact of Glucocorticoids on Mesenchymal Stromal Cell Differentiation - Can Hypoxia Counteract?
Authors: A. Lang, K. Schmidt-Bleek, M. Jackstadt, T. Gaber, G. Duda, F. Buttgereit
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Glucocorticoids (GC) represent most frequently-used anti-inflammatory drugs in rheumatology. However, especially if given at higher dosages for a longer time, they have the potential to induce adverse effects such as GC-induced delayed bone regeneration and osteoporosis. Several studies have demonstrated the negative influence of anti-inflammatory drugs during bone healing. One suggested mechanism is that GC inhibit the differentiation potential of invading mesenchymal stromal cells (MSC). Fracture healing is divided into four phases including the initial inflammatory phase where blood vessels are disrupted at the fracture site and inflammatory cells enter the area. It is thought that hypoxia influences the microenvironment. One key regulator of cellular adaption to hypoxia is the hypoxia-inducible factor- (HIF) that can be stabilized via different factors called chemical hypoxia inducers. HIF is a transcription factor and initiates processes that further the consecutive steps of healing and MSC differentiation. <h3>Objectives</h3> Our study focuses on the understanding of GC induced effects on MSC differentiation and we aim at applying chemically hypoxia inducers to prevent negative side effects. <h3>Methods</h3> Human bone marrow derived MSC were cultured and differentiated into osteoblasts under normoxic (37°C, 5% CO<sub>2</sub>, 18% O<sub>2</sub>) or hypoxic (37°C, 5% CO<sub>2</sub>, 1% O<sub>2</sub>) conditions. Different concentrations of Dexamethasone (10<sup>–3</sup>–10<sup>–8</sup>M) and chemical hypoxia inducers were examined. The calcification process during osteogenesis was analyzed using a quantifiable Alizarin Red staining method. Furthermore, we performed a preliminary proof of concept study in a mouse osteotomy model (3 weeks; n=2 per group). <h3>Results</h3> We could demonstrate a concentration-dependent inhibitory effect of Dexamethasone on osteogenesis which could be considerably antagonized by hypoxia or chemically hypoxia inducers <i>in vitro</i>. In the mouse model, preliminary <i>in vitro</i> μCT data indicated a positive effect on healing processes by means of increased callus volume (TV, BV) after three weeks by applying chemical hypoxia inducers into the fracture gap at the time of the osteotomy compared to the controls. <h3>Conclusions</h3> Our data demonstrate that hypoxia promotes osteogenic differentiation and has the ability to counteract the negative impact of GC on osseous differentiation. The preliminary <i>in vivo</i> data support the <i>in vitro</i> findings. Therefore, a combination of chemical hypoxia inducers may represent a promising tool to overcome bone healing disorders in GC treated patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2882
Do “America's Best Hospitals” Perform Better for Acute Myocardial Infarction?
Authors: Jersey Chen, Martha J. Radford, Yun Wang, Thomas A. Marciniak, Harlan M. Krumholz
Journal: New England Journal of Medicine (1999)

“America's Best Hospitals,” an influential list published annually by U.S. News & World Report, assesses the quality of hospitals. It is not known whether patients admitted to hospitals ranked at the top in cardiology have lower short-term mortality from acute myocardial infarction than those admitted to other hospitals or whether differences in mortality are explained by differential use of recommended therapies.
Of Pedigrees, Probes, and p53: 20 Years of Family Studies
Authors: N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Of Pedigrees, Probes, and p53: 20 Years of Family Studies Get access Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 23, 4 December 1991, Pages 1707–1709, https://doi.org/10.1093/jnci/83.23.1707 Published: 04 December 1991
EFFECTS OF DARK CHOCOLATE (DC) ON EXERCISE CAPACITY IN SEDENTARY OLDER ADULTS (A DOUBLE BLIND PLACEBO CONTROLLED TRIAL)
Authors: Pam R. Taub, Minal Patel, Erin Higginbotham, Luis Ramon, Aldo Moreno-Ulloa, Israel Ramirez-Sanchez, Guillermo Ceballos, Francisco Villarreal
Journal: Journal of the American College of Cardiology (2015)
GENO-33PATIENT DERIVED GLIOBLASTOMA CELL LINES RECAPITULATE PARENTAL TUMORS' MOLECULAR LANDSCAPE
Authors: Shai Rosenberg, Maité Verreault, Charlotte Schmitt, Justine Guegan, Jeremy Guehennec, Camille Levasseur, Yannick Marie, Karima Mokhtari, Khê Hoang-Xuan, Marc Sanson, Jean-Yves Delattre, Ahmed Idbaih
Journal: Neuro-Oncology (2015)