tbuckley/cabot-search huggingface dataset:
Aging, emotional states, and memory
Authors: D Deptula, R Singh, N Pomara
Journal: American Journal of Psychiatry (1993)

This study compared the relation between negative mood states and memory in young and elderly subjects.Forty-five normal, healthy young volunteers (ages 19-35 years) and 45 normal, healthy elderly volunteers (ages 60-78 years) were administered a verbal list-learning task and self-rated scales of affective states.The elderly group, but not the young group, consistently exhibited significant correlations between their performance on verbal recall measures and their ratings of their anxiety, depression, and withdrawal; i.e., within the elderly group, higher levels of negative affective states were associated with poorer memory.These findings indicate that aging modulates the relation between emotional state and memory functions, and they are consistent with the hypothesis that the elderly are more vulnerable than the young to the adverse effects of negative emotional states on memory. Therefore, even in normal elderly individuals without diagnosable psychopathology, negative affective states (such as anxiety and depression) may interfere with memory functioning.
Home care of chronic respiratory disease
Authors: R. M. Cherniack
Journal: JAMA (1969)

From 1958 to 1967, 148 patients with severe chronic respiratory insufficiency have been managed in a "Home Care Program," which has primarily involved concentrated care in the home by nurses and other paramedical personnel, as well as by hospital residents. Therapeutic measures were directed at reduction in work of breathing, an increase in alveolar ventilation and physical activity, and when necessary, provision of mechanical aids. Of the patients, 55% required rehospitalization, but for only 5.7% of the total days on home care. Of the 148 patients, 47% died after they had been on the program for an average of 361 days. The cost of the program was slight, particularly when compared to that of a hospital bed, and the cost of physician care constituted a very small portion of the total cost.
The application of positron emission tomography to the study of panic disorder
Authors: E M Reiman, M E Raichle, E Robins, F K Butler, P Herscovitch, P Fox, J Perlmutter
Journal: American Journal of Psychiatry (1986)

Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections, is proposed.
Rethinking medical oncology training and education.
Authors: F L Meyskens
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.3.561 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3351562 Rethinking medical oncology training and education. F L Meyskens JrxF L Meyskens JrSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.3.561 PDF "Rethinking medical oncology training and education.." Journal of Clinical Oncology, 6(3), pp. 561–562© 1988 by American Society of Clinical Oncology
Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells
Authors: Hao Su, Pengcheng Zhang, Andrew G Cheetham, Jin Mo Koo, Ran Lin, Asad Masood, Paula Schiapparelli, Alfredo Quiñones-Hinojosa, Honggang Cui
Journal: Theranostics (2016)

Chemical modification of small molecule hydrophobic drugs is a clinically proven strategy to devise prodrugs with enhanced treatment efficacy.While this prodrug strategy improves the parent drug's water solubility and pharmacokinetic profile, it typically compromises the drug's potency against cancer cells due to the retarded drug release rate and reduced cellular uptake efficiency.Here we report on the supramolecular design of self-assembling prodrugs (SAPD) with much improved water solubility while maintaining high potency against cancer cells.We found that camptothecin (CPT) prodrugs created by conjugating two CPT molecules onto a hydrophilic segment can associate into filamentous nanostructures in water.Our results suggest that these SAPD exhibit much greater efficacy against primary brain cancer cells relative to that of irinotecan, a clinically used CPT prodrug.We believe these findings open a new avenue for rational design of supramolecular prodrugs for cancer treatment.
PTH-143 Application of gold nanorods for<i>in vivo</i>theranostics of human oesophageal adenocarcinoma
Authors: M Singh, E Nabavi, Y Zhou, H Zhao, D Ma, AE Cass, GB Hanna, DS Elson
Journal: Gut (2015)

<h3>Introduction</h3> Gold nanoparticles possess unique physiochemical properties due to their ability to target cancerous tissue and a strongly enhanced absorption of visible and near infra-red (NIR) light resulting in hyperthermia and photothermal therapy (PTT). Fluorescence emission from their functionalised surface provides diagnostic information regarding tumour location. Their biocompatibility <i><i>in vivo</i></i>is facilitated through surface polymer coating. We investigate these properties in human oesophageal adenocarcinoma by examining <i><i>in vitro</i></i>targeting of functionalised gold nanorods to human oesophageal adenocarcinoma cells (FLO-1) and evaluating the PTT of tumour xenografts <i><i>in vivo</i></i>. <h3>Method</h3> Multifunctional coated gold nanorods (GNRs) were fabricated using a seed-mediated method. Subsequent EDC/NHS chemistry functionalised the GNRs with a fluorophore (Cy 5.5) modified with anti-EGFR antibody. FLO-1 cells were fixed in paraformaldehyde in 0.1 mol/l PBS solution. Dilute functionalised GNRs were added and incubated overnight. Slides were then washed with PBS and stained with the nuclear dye DAPI prior to microscopic examination. Tumour xenografts were established in immunodeficient mice by subcutaneous inoculation of FLO-1 cells. When tumour size reached 5 mm, functionalized GNRs were administered either intratumourally (I. T.) or intravenously (I. V.). Fluorescence spectroscopy was performed followed by NIR irradiation of the tumour for 3 min using an 808 nm laser at 0.92 W. A thermal imaging camera measured the temperature changes that occurred. Inductively coupled plasma mass spectrometry (ICP-MS) measured gold concentrations in blood and organs remote to the tumour. <h3>Results</h3> Functionalised GNRs with a peak optical absorption at 808 nm were used. Fluorescence imaging of immunohistochemically stained FLO-1 cells demonstrated active <i><i>in vitro</i></i>targeting of GNRs. NIR irradiation of tumours established 12°C and 18°C temperature increases in mice receiving I. V. and I. T. GNRs respectively. Histological examination of tumour sites showed fully preserved tissue layers with no signs of proliferating tumour. ICP-MS revealed no evidence of toxic accumulation of gold in blood, kidneys, liver or spleen after 30 days. <h3>Conclusion</h3> Fluorescence detection of functionalised GNRs that localise to cancerous tissue may enhance oesophageal cancer diagnosis. When coupled with NIR irradiation, this is an effective method of inducing irreversible tumour photodestruction, with minimal collateral damage expected in healthy tissues. The strong absorption of GNRs of relatively low laser energies renders the therapy method minimally invasive. <h3>Disclosure of interest</h3> None Declared.
Neural Modulation of Transcapillary Exchange of Fluid and Solutes in Whole-Organ Preparations
Authors: John N. Diana, Cheryl M. Heesch
Journal: Circulation Research (1987)

Activation of sympathetic adrenergic postganglionic fibers that release norepinephrine at the neuromuscular junction can influence resistance, capacitance, and exchange functions in the microcirculation. Although the predominant response is an increase in precapillary resistance that reduces blood flow through the tissue (at constant pressure perfusion), there are two distinct components that can be separated into an initial (1-2-minute) and late (2-15-minute) response. The initial (1-2-minute) response is a decrease in venous and capillary pressures in passive response to decreased flow promoted by an increase in precapillary resistance. Venous pressures are reduced even though postcapillary resistance is increased. The decrease in capillary pressure promotes absorption of fluid from tissue to plasma. Venous constriction results in a translocation of blood from the terminal venous system into the larger venous conduits toward the heart. Total blood volume in an isolated organ system decreases and is manifested as a decrease in volume (plethysmographic) or weight (gravimetric). The decrease in volume is result of three interrelated factors: 1) decrease in flow through the organ, 2) active venoconstriction and a translocation of blood out of the organ, and 3) absorption of fluid from tissue to plasma, which flows out of the organ with venous drainage. With continued sympathetic nervous system stimulation, the late response (3-15 minutes) is a gradual decrease in precapillary resistance that increases blood flow through the organ. Venous and capillary pressures passively increase in association with increases in flow.(ABSTRACT TRUNCATED AT 250 WORDS)
MiR-298 Counteracts Mutant Androgen Receptor Toxicity in Spinal and Bulbar Muscular Atrophy
Authors: Naemeh Pourshafie, Philip R Lee, Ke-lian Chen, George G Harmison, Laura C Bott, Masahisa Katsuno, Gen Sobue, Barrington G Burnett, Kenneth H Fischbeck, Carlo Rinaldi
Journal: Molecular Therapy (2016)

Spinal and bulbar muscular atrophy (SBMA) is a currently untreatable adult-onset neuromuscular disease caused by expansion of a polyglutamine repeat in the androgen receptor (AR). In SBMA, as in other polyglutamine diseases, a toxic gain of function in the mutant protein is an important factor in the disease mechanism; therefore, reducing the mutant protein holds promise as an effective treatment strategy. In this work, we evaluated a microRNA (miRNA) to reduce AR expression. From a list of predicted miRNAs that target human AR, we selected microRNA-298 (miR-298) for its ability to downregulate AR mRNA and protein levels when transfected in cells overexpressing wild-type and mutant AR and in SBMA patient-derived fibroblasts. We showed that miR-298 directly binds to the 3'-untranslated region of the human AR transcript, and counteracts AR toxicity in vitro. Intravenous delivery of miR-298 with adeno-associated virus serotype 9 vector resulted in efficient transduction of muscle and spinal cord and amelioration of the disease phenotype in SBMA mice. Our findings support the development of miRNAs as a therapeutic strategy for SBMA and other neurodegenerative disorders caused by toxic proteins. Spinal and bulbar muscular atrophy (SBMA) is a currently untreatable adult-onset neuromuscular disease caused by expansion of a polyglutamine repeat in the androgen receptor (AR). In SBMA, as in other polyglutamine diseases, a toxic gain of function in the mutant protein is an important factor in the disease mechanism; therefore, reducing the mutant protein holds promise as an effective treatment strategy. In this work, we evaluated a microRNA (miRNA) to reduce AR expression. From a list of predicted miRNAs that target human AR, we selected microRNA-298 (miR-298) for its ability to downregulate AR mRNA and protein levels when transfected in cells overexpressing wild-type and mutant AR and in SBMA patient-derived fibroblasts. We showed that miR-298 directly binds to the 3'-untranslated region of the human AR transcript, and counteracts AR toxicity in vitro. Intravenous delivery of miR-298 with adeno-associated virus serotype 9 vector resulted in efficient transduction of muscle and spinal cord and amelioration of the disease phenotype in SBMA mice. Our findings support the development of miRNAs as a therapeutic strategy for SBMA and other neurodegenerative disorders caused by toxic proteins.
Critique of the Danish-American studies of the adopted-away offspring of schizophrenic parents
Authors: T Lidz, S Blatt, B Cook
Journal: American Journal of Psychiatry (1981)

Studies of the adopted-away children of schizophrenic parents that have claimed to have shown a strong genetic factor in the etiology of schizophrenia have had a great impact on psychiatry, including effects on the direction and support of research. An examination of these studies, however, controverts these conclusions. The authors demonstrate that without the inclusion of parents with manic-depressive and indefinite diagnoses in the index group, there is no statistically significant difference between the number of offspring with schizophrenic spectrum diagnoses in the index and control groups.
Operations for Varicose Veins
Authors: R. R. Foote
Journal: BMJ (1957)

<h3>Background</h3> Dispensing of investigational drugs is a more complex and longer process than dispensing commercial medications. Therefore, a correct prescription is essential to minimise the waiting time for patients. <h3>Purpose</h3> To measure the delay in dispensing investigational drugs (ID) caused by an incomplete medication prescription (IMP). <h3>Material and methods</h3> A prospective, observational, descriptive study was carried out in the pharmacy clinical trials department of a general hospital. All IMPs were recorded and the delay in dispensing was measured during March 2015. The ID dispensing process starts when the investigator requests the ID through the ID request (IDR). After that, the prescription is validated and dispensed by the pharmacist. A correct IDR should contain the protocol’s name, investigator’s signature, patient code, order date and drug designation. If one of these fields was missing, it was considered an IMP. For every IDR the pharmacist registered the following: the time when the prescription was handed in, mistakes identified and dispensing time. All IDR incidents were reported to the investigator and resolved before dispensing them. The average dispensing time for a correct prescription was compared against the average dispensing time of an IMP, in order to measure the delay in dispensing an ID. <h3>Results</h3> 301 IDRs were analysed. The highest number of IDRs were from the oncology and haematology departments (54.1% (n = 163) vs 26.2% (n = 79)). 35 IMPs (11.6%) were detected: 20 (6.6%) from the haematology department, 9 (3.3%) from the oncology department and six from other departments. On average, the dispensing process time for a correct IDR was 5.8 ± 5.1 min compared with 16.0 ± 11.0 min to dispense an ID with an IMP. The average delay in the dispensing process was 10.2 min. The difference was found to be statistically significant (p &lt; 0.05). <h3>Conclusion</h3> The majority of IMPs were found from the haematology and oncology departments, both departments having the highest number of IDRs. IMPs increase dispensing time and can even triple patient waiting time. No conflict of interest.
High Dose Therapy and Autologous Stem Cell Transplantation in Marginal Zone Lymphoma : An EBMT-FIL-Gimeto Retrospective Study
Authors: Irit Avivi, Luca Arcaini, Virginia Ferretti, Ariane Boumendil, Herve Finel, Cristiana Pascutto, Giuseppe Milone, Francesco Zaja, Devizzi Liliana, Maurizio Musso, Blaise Didier, Gilles Salles, Mohammed Wattad, Emmanuelle Nicolas-Virelizier, Martin Gramatzki, Jean-Henri Bourhis, Denis Caillot, Shannon Haenel, Anette Haenel, Gerhard Held, Catherine Thieblemont, Pavel Jindra, David Pohlreich, François Guilhot, Martin Bornhaeuser, Per T. Ljungman, Christof Scheid, Norbert Ifrah, Christian Berthou, Peter Dreger, Silvia Montoto, Annarita Conconi
Journal: Blood (2014)
Abstract IA28: Towards a therapy for Angelman syndrome by targeting a long noncoding RNA to active UBE3A
Authors: Linyan Meng, Amanda J. Ward, C. Frank Bennett, Arthur Beaudet, Frank Rigo
Journal: Cancer Research (2016)

Abstract Angelman syndrome (AS) is a single gene disorder characterized by intellectual disability, developmental delay, behavioral uniqueness, speech impairment, seizures, and ataxia. It is caused by maternal deficiency of the imprinted gene UBE3A, encoding an E3 ubiquitin ligase. All patients carry at least one copy of paternal UBE3A, which is intact but silenced by a nuclear-localized long non-coding RNA, UBE3A antisense transcript (UBE3A-ATS). Murine Ube3a-ATS reduction by either transcription termination or topoisomerase I inhibition increased paternal Ube3a expression. Despite a clear understanding of the disease-causing event in AS and the potential to harness the intact paternal allele to correct disease, no gene-specific treatment exists for patients. Here we developed a potential therapeutic intervention for AS by reducing Ube3a-ATS with antisense oligonucleotides (ASOs). ASO treatment achieved specific reduction of Ube3a-ATS and sustained unsilencing of paternal Ube3a in neurons in vitro and in vivo. Partial restoration of UBE3A protein in an AS mouse model ameliorated some cognitive deficits associated with the disease. Although additional studies of phenotypic correction are needed, for the first time we developed a sequence-specific and clinically feasible method to activate expression of the paternal Ube3a allele. Citation Format: Linyan Meng, Amanda J. Ward, C. Frank Bennett, Arthur Beaudet, Frank Rigo. Towards a therapy for Angelman syndrome by targeting a long noncoding RNA to active UBE3A. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr IA28.
Adverse Prognosis Of Extramedullary Disease In Patients With Chronic Myeloid Leukemia (CML) In The Tyrosine Kinase Inhibitor (TKI) Era: a Cohort Study Of 283 Blastic Phase CML Patients
Authors: Young Kwang Chae, Hagop M Kantarjian, Muhamed Baljevic, Alfonso Quintás-Cardama, Gautam Borthakur, Tapan M. Kadia, Susan O'Brien, Carlos G. Romo, Sherry R. Pierce, Elias Jabbour, Jorge E. Cortes
Journal: Blood (2013)
Exposure of Oil Refinery Workers to the Lubricating-Dewaxing Process
Authors: Nathan Mantel
Journal: JNCI Journal of the National Cancer Institute (1985)

Journal Article Exposure of Oil Refinery Workers to the Lubricating-Dewaxing Process Get access Nathan Mantel Nathan Mantel Mathematics, Statistics and Computer Science, The American University, 4900 Auburn Avenue, Bethesda, MD 20814 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 75, Issue 1, July 1985, Pages 180–181, https://doi.org/10.1093/jnci/75.1.180 Published: 01 July 1985
a Proposal for a New Staging System of Extranodal Natural Killer T-cell Lymphoma, Nasal-Type: a Multicenter Study of Chinese Southwest Oncology Group (CSWOG)
Authors: Huangming Hong, Xin Du, Mingzhi Zhang, Jinghua Wang, Jun Zhu, He Huang, Ting Liu, Fanyi Meng, Gang Wu, Ye Guo, Weili Zhao, Jie Jin, Juan Li, Yanming Deng, Kangsheng Gu, Xiangyuan Wu, Xiaoyan Ke, Derong Xie, Daren Lin, Tongyu Lin
Journal: Blood (2014)
The Delineation of an MMPI Symptom Pattern Unique to Lithium Responders
Authors: Fred A. Steinberg
Journal: American Journal of Psychiatry (1979)

The author attempted to determine whether the Minnesota Multiphasic Personality Inventory (MMPI) would be sensitive to a symptom pattern unique to lithium-responsive patients regardless of diagnosis. Statistical analyses of the MMPI scores of lithium responders, lithium nonresponders, and a group of patients receiving other psychotropic drugs revealed that the depression, psychasthenia, mania, and social introversion scale scores significantly differentiated the lithium response and lithium nonresponse groups. No strong indications of significant difference were found between the MMPI scale scores of the lithium nonresponse and psychotropic groups. The results suggest that there is a lithium-responsive syndrome that exhibits a distinctive symptom pattern regardless of its varying phenomenological features in different individuals.
Removal of a large, 40-mm, submucosal leiomyoma using submucosal tunneling endoscopic resection and extraction of specimen using a distal mucosal incision
Authors: Jun Ng, Philip Chiu, Asim Shabbir, Jimmy So
Journal: Endoscopy (2015)

Submucosal tunneling endoscopic resection (STER) combines the techniques of peroral endoscopic myotomy [1] and endoscopic submucosal dissection for removal of upper gastrointestinal tract submucosal tumors (SMTs). STER has been used for removal of small SMTs below 20 mm with low complication rates [2] [3] [4]. This report describes the removal of a large 40-mm esophageal SMT using STER, and describes a novel technique to aid the en bloc extraction of large SMTs during STER.
CEA response is associated with tumor response and survival in patients with KRAS exon 2 wild-type and extended RAS wild-type metastatic colorectal cancer receiving first-line FOLFIRI plus cetuximab or bevacizumab (FIRE-3 trial)
Authors: M. Michl, S. Stintzing, L. Fischer von Weikersthal, T. Decker, A. Kiani, U. Vehling-Kaiser, S.-E. Al-Batran, T. Heintges, C. Lerchenmueller, C. Kahl, G. Seipelt, F. Kullmann, M. Stauch, W. Scheithauer, J. Hielscher, M. Scholz, S. Mueller, M.M. Lerch, D.P. Modest, T. Kirchner, A. Jung, V. Heinemann
Journal: Annals of Oncology (2016)
On the Skin Eruptions which Occur in Septicaemia Following Scarlet Fever and Diphtheria
Authors: N. S. Manning
Journal: BMJ (1893)

SKIN ERUPTIONS IN SEPTIC2EMIA.[2r!o= 691 tumour extends ii inch below the level of the umbilicus, and 1 inch across the middle line.It can be distinctly felt in the flank and can be easily moved when one hand is placed on the front of the abdomen and the ether in the flank.Urine: acid, specific gravity 1018, contains a con- eiderable amount of albumen.June 27th 1891 An incision was made over the centre of the tumour, as