tbuckley/cabot-search huggingface dataset:
SAT0073 Arterial Hypertension In Rheumatoid Arthritis Without Cardiovascular Disease: High Prevalence, Low Awareness, Poor Control And Increased Vascular Damage-Associated “White Coat” Phenomenon
Authors: A. Protogerou, E. Zampeli, G. D. Konstantonis, K. Arida, D. B. Panagiotakos, A. A. Argyris, C. Pitsavos, G. D. Kitas, P. P. Sfikakis
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid arthritis (RA) is associated with a high cardiovascular disease (CVD) risk, whereas the prevalence and significance of arterial hypertension, the major modifiable CVD risk factor, is still a matter of investigation in these patients (1-3). <h3>Objectives</h3> To examine the characteristics of arterial hypertension in a typical, contemporary RA cohort. <h3>Methods</h3> In 214 consecutive RA patients free of CVD (aged 58.4±12.3 years, 82% women) we conducted a comprehensive study including: (i) guideline-based (4) assessments of office and out-of-office blood pressure (BP) (7-days home BP monitoring or 24hr ambulatory BP monitoring); (ii) vascular studies to detect end-organ damage. Office BP assessments in a 1:1 age- and gender-matched general population group were used for comparison. <h3>Results</h3> The prevalence of known hypertension in RA was 44%. Of the remaining patients, 2 out of 5 had systolic BP/diastolic BP higher than 139/89 mmHg at office, contributing to a double prevalence than the general population (67% vs. 34%). Out-of-office and/or ambulatory 24-hourBP measurements revealed an actual 54% prevalence of hypertension in RA, i.e. an additional 10% of patients was unaware of having hypertension. Hypertension was positively associated with age and body mass index, and inversely with the use of biologic drugs. Of patients with known hypertension 29% were not well controlled. Overall, almost 1 out of 5 presented the 'white coat' phenomenon, irrespective of antihypertensive drug use. Interestingly, an intermediately compromised vascular phenotype in terms of aortic stiffness, carotid hypertrophy and ankle-brachial index was evident in 'white coat' phenomenon patients, lying between patients with sustained normotension and sustained hypertension. <h3>Conclusions</h3> Accurate and prompt diagnosis, and effective treatment of arterial hypertension is of key importance in RA and should be placed at the top of both clinical and research agenda for CVD risk reduction. <h3>References</h3> Aviña-Zubieta JA, et al. Risk of Cardiovascular Mortality in Patients With Rheumatoid Arthritis: A Meta-Analysis of Observational Studies. Arthritis Rheum 2008;59:1690-7. Panoulas VF, et al. Prevalence and associations of hypertension and its control in patients with rheumatoid arthritis. Rheumatology 2007; 46:1477-82. Liao KP, Solomon DH. Traditional cardiovascular risk factors, inflammation and cardiovascular risk in rheumatoid arthritis. Rheumatology 2013; 52:45-52. Mancia G, et al.; ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 2007; 25:1751-62. <h3>Disclosure of Interest</h3> None Declared
The Precipitin Test for Bence-Jones Protein
Authors: Fred C. Collier, Paul Jackson
Journal: New England Journal of Medicine (1953)

IN a previous communication1 the need for a specific, sensitive test for Bence-Jones protein was stressed. The surprising infrequency with which positive findings for Bence-Jones protein are recorded lends weight to this concept. Of equal importance is the fact that the diagnosis of multiple myeloma, made frequently but late in the course of the disease, might be effected considerably earlier through employment of a more sensitive test for Bence-Jones protein, which, if present, is often the initial indicator of the fundamental pathologic process. A review of the hospital charts of 246 patients with diagnoses of multiple myeloma discloses a high . . .
Abstract LB-54: The foundation for melanoma research
Authors: Richard Beston
Journal: Cancer Research (2012)

Abstract The Foundation for Melanoma Research was founded in 1999 by Noreen O'Neill, a prominent Philadelphia businessperson. Noreen, who was diagnosed with malignant melanoma in 1995 and lost her battle to the disease in 2000. She looked to volunteer with organizations dedicated to advancing treatments for melanoma patients. Finding none, she decided to build one herself. The organization is dedicated to raising awareness about melanoma and funding research into increased prevention, early detection, and new treatments, with the eventual goal of finding a cure. All funds raised go to melanoma research scientists at The Wistar Institute, a world-reknowned biomedical research organization at the University of Pennsylvania in Philadelphia. Wistar continues to be on the cutting-edge of melanoma discoveries towards a cure. The Noreen O'Neill Foundation for Melanoma Research is dedicated to raising awareness about melanoma and funding research into increased prevention, early detection, and new treatments. Annual intiatives include Running for Cover 5k walk/run, Date With a Plate, the annual Wallace Clark Lectures, and a close tie with Philadelphia professional sports teams. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-54. doi:1538-7445.AM2012-LB-54
Abstract 4354: Celecoxib reduces MGMT expression and potentiates the effect of temozolomide in childhood medulloblastoma
Authors: Ninib Baryawno, Jelena Milosevic, Malin Wickström, Baldur Sveinbjörnsson, Staffan Eksborg, Per Kogner, John I. Johnsen
Journal: Cancer Research (2010)

Abstract Background: O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair protein that protects DNA from the biological effects of alkylating agents. MGMT has been implicated in resistance to alkylating drugs such as temozolomide used in the clinic against brain tumors. Temozolomide has been shown to be ineffective in tumors expressing MGMT and in medulloblastoma high expression of MGMT is correlated with poor prognosis. Therefore, the demand to find agents that deplete MGMT is warranted. Methods: medulloblastoma cell cytotoxicity of chemotherapeutic drugs in combination with Celecoxib was examined in MGMT positive cell lines using fluorometric microculture cytotoxicity assay. In vivo, nude NMRI mice carrying MGMT positive D283 MED xenografts were treated with celecoxib in combination with temozolomide. For mechanistic studies, western blot and quantitative PCR were used. Results: the clinically available COX-2 inhibitor Celecoxib induced a synergistic or an additive cytotoxic effect in combination with Temozolomide, Cyclophosphamide, Doxorubicin, Irinotecan, Vincristine, Rapamycin or CCI-779 in vitro. In vivo, Celecoxib synergistically potentiates the effect of Temozolomide through downregulation of MGMT expression. Conclusions: this study shows that Celecoxib reduces the DNA repair capacity of MGMT in medulloblastoma and increases the susceptibility to temozolomide. These findings support the use of pharmacological MGMT depletion as a rational approach for intensification of temozolomide therapy in the treatment of medulloblastoma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4354.
Measles Outbreak in a Fully Immunized Secondary-School Population
Authors: Tracy L. Gustafson, Alan W. Lievens, Philip A. Brunell, Ronald G. Moellenberg, Christopher M.G. Buttery, Lynne M. Sehulster
Journal: New England Journal of Medicine (1987)

An outbreak of measles occurred among adolescents in Corpus Christi, Texas, in the spring of 1985, even though vaccination requirements for school attendance had been thoroughly enforced. Serum samples from 1806 students at two secondary schools were obtained eight days after the onset of the first case. Only 4.1 percent of these students (74 of 1806) lacked detectable antibody to measles according to enzyme-linked immunosorbent assay, and more than 99 percent had records of vaccination with live measles vaccine. Stratified analysis showed that the number of doses of vaccine received was the most important predictor of antibody response. Ninety-five percent confidence intervals of seronegative rates were 0 to 3.3 percent for students who had received two prior doses of vaccine, as compared with 3.6 to 6.8 percent for students who had received only a single dose. After the survey, none of the 1732 seropositive students contracted measles. Fourteen of 74 seronegative students, all of whom had been vaccinated, contracted measles. In addition, three seronegative students seroconverted without experiencing any symptoms. We conclude that outbreaks of measles can occur in secondary schools, even when more than 99 percent of the students have been vaccinated and more than 95 percent are immune.
PREDICTIVE ACCURACY OF RESTING GRADIENT (PD/PA) FOR IDENTIFYING ISCHEMIC CORONARY LESIONS
Authors: Shiv Kumar Agarwal, Sameer Raina, Mohan Edupuganti, Ahmed Almomani, Jason Payne, Naga Venkata Pothineni, Fnu Shailesh, Srikanth Kasula, Sabha Bhatti, Zubair Ahmed, Barry Uretsky, Abdul Hakeem
Journal: Journal of the American College of Cardiology (2016)
SAT0196 Scoring of Spinal Lesions Compatible with Axial Spondyloarthritis on MRI in Clinical Practice by Local Radiologist or Rheumatologist in Desir; Comparison with Central Reading
Authors: M. de Hooge, J. Pialat, M. Reijnierse, D. van der Heijde, P. Claudepierre, A. Saraux, M. Dougados, A. Feydy
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> In clinical practice radiologists and rheumatologists assess whether lesions compatible with axial SpondyloArthritis (axSpA) are present on spinal MRI <h3>Objectives</h3> To compare the results of local readings (LocR) to centralized reading (CentR) as external standard of BME and structural lesions on MRI-spine, in patients (pts) with inflammatory back pain (IBP) <h3>Methods</h3> Pts aged 18-50 with recent IBP (≥3 months, ≤3 years) from 25 participating centers in France were included in the DESIR-cohort (n=708). All available baseline MRIs-spine were scored on BME and structural lesions as present, absent or doubtful by the local radiologist/rheumatologist who might have access to clinical data. In addition, 2 well-calibrated centralized readers independently scored the same MRIs for BME lesions and structural lesions (fatty lesions, erosions and (bridging) syndesmophytes). In case the centralized readers disagreed, an experienced radiologist served as adjudicator. Agreement between CentR and LocR was calculated excluding the cases assessed as doubtful by LocR (kappa κ) <h3>Results</h3> BME/structural lesions were in 492/492 pts scored by a radiologist, 206/205 by a rheumatologist and in 32/32 pts by both. The k agreement between LocR and CentR was 0.27 for BME lesions and 0.13 for structural lesions. For radiologists, κ=0.36 for BME, and κ=0.15 for structural lesions. For rheumatologists κ=0.006 for BME and κ=0.12 for structural lesions. Overall, local specialists are highly overrating positive findings: 42.3% and 85.7% of the positive MRIs for BME are scored negative by the central read (radiologists and rheumatologist respectively). Similarly findings for structural lesions: 48.4% and 70% of MRIs positive for structural lesions are scored normal by central reading <h3>Conclusions</h3> Both local radiologists, but especially rheumatologists overrate the presence of BME lesions and structural lesions on MRI of the spine compared to trained central readers. These results do not even take doubtful cases into account <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5456
U.S. Outpatient Antibiotic Prescribing, 2010
Authors: Lauri A. Hicks, Thomas H. Taylor, Robert J. Hunkler
Journal: New England Journal of Medicine (2013)

Treating infections is one of the greatest successes in medicine, but it may be too easy to prescribe antibiotics. This report reviews U.S. outpatient antibiotic use in 2010.
WHAT DO REAL WORLD DATA SAY ABOUT SAFETY AND RESOURCE USE OF ORAL ANTAGONISTS? EARLY ANALYSIS OF NEWLY ANTICOAGULATED NON-VALVULAR ATRIAL FIBRILLATION PATIENTS USING EITHER APIXABAN, DABIGATRAN, RIVAROXABAN OR WARFARIN
Authors: Xianying Pan, Shital Kamble, Leah Burns, Hugh Kawabata, Jack Mardekian, Cristina Masseria, Kiran Gupta, Hemant Phatak, Gregory Y.H. Lip
Journal: Journal of the American College of Cardiology (2016)
Ghrelin Concentrations in Morbidly Obese Patients after Adjustable Gastric Banding
Authors: Ursula Hanusch-Enserer, Georg Brabant, Michael Roden
Journal: New England Journal of Medicine (2003)

To the Editor: It has been suggested that the reduction in plasma ghrelin concentrations in five morbidly obese patients after treatment with a proximal Roux-en-Y gastric bypass contributed to the weight-reducing effect of the surgery.1 This hypothesis has been questioned,2 because decreased plasma ghrelin concentrations are present in obese people before any intervention and were documented approximately 1.4 years after gastric bypass surgery, when weight loss of approximately 36 percent had occurred. Bariatric surgery is becoming more common — particularly, laparoscopic adjustable gastric banding. This procedure, which was recently approved by the Food and Drug Administration, causes less dramatic weight . . .
Safety and efficacy of DHA-paclitaxel (TXP) in non-small cell lung cancer (NSCLC)
Authors: L. Schacter, D. Talbot, P. Ellis, D. Dunlop, N. Thatcher
Journal: Journal of Clinical Oncology (2004)

7111 Background: DHA-paclitaxel (Taxoprexin [TXP]) is a covalent conjugate of paclitaxel and docosahexanoic acid that has greater tumour specificity in pre-clinical models than paclitaxel. It accumulates in tumour tissue where it is cleaved to paclitaxel. The objective of this multi-centre study was to determine the efficacy and tolerability of TXP as first line therapy in advanced NSCLC. Methods: A total of 44 patients (pts) [29 male, 15 female, median age 61y (range 39–74) PS 0 (11pts) PS 1 (33pts)] with pathologically confirmed stage IIIB or IV NSCLC and no previous cytotoxic treatment were enrolled. Pts were required to have adequate renal, hepatic and bone marrow function and have measurable disease. TXP was administered iv over 2 hours q21 days at one of two doses, 900 mg/m2 (31pts) and 1100 mg/m2 (13pts). Due to excess toxicity, including one toxic death, the starting dose was reduced to 900 mg/m2. As of November 2003 four pts remain on follow-up. Results: Twenty-eight courses (mean 2.1) were administered in the 1100 mg/m2 cohort and 109 courses (mean 3.5) for 900 mg/m2. Neutropenia was the primary toxicity and was dose related; 21 of 31 (68%) of patients treated at 900 mg/m2 had grade 3 or 4 neutropenia while 10 of 13 (77%) at 1100 mg/m2 had these grades of neutropenia. No grade 3 or 4 nausea /or vomiting, stomatitis or neuropathies were observed. Forty patients were evaluable for response: 900 mg/m2 PR 2/30 (6.7%), SD 13/30 (43%); 1100 mg/m2 PR 0/10 (0%), SD 3/10 (30%). Survival (see table) at the 900 mg/m2 dose level was comparable to that seen with standard platinum based combination chemotherapy. (Supported by American Regent.) Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Protarga, Inc. Luitpold Pharmaceuticals
"Bonanza Sweepstakes" Bags Millions For Cancer Groups--How Much For Cancer?
Authors: K. Ruddon
Journal: JNCI Journal of the National Cancer Institute (1989)

“Bonanza Sweepstakes” Bags Millions For Cancer Groups—How Much For Cancer? Get access Kate Ruddon Kate Ruddon Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 2, 18 January 1989, Pages 86–91, https://doi.org/10.1093/jnci/81.2.86 Published: 18 January 1989
Hypofibrinogenemia in non-M3 acute myeloid leukemia. Incidence, clinical and laboratory characteristics and prognosis
Authors: A Weltermann, I Pabinger, K Geissler, U Jäger, H Gisslinger, P Knöbl, S Eichinger, PA Kyrle, P Valent, W Speiser, I Schwarzinger, C Mannhalter, K Lechner
Journal: Leukemia (1998)
Smoking Banned in Leading Cancer Centers
Authors: H. R. Neville
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article Smoking Banned in Leading Cancer Centers Get access Heather R. Neville Heather R. Neville Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 11, 3 August 1988, Page 798, https://doi.org/10.1093/jnci/80.11.798 Published: 03 August 1988
Preoperative Evaluation of Possible Cross-Circulation in Conjoined Twins by Hepatobiliary Scintigraphy
Authors: Yue Chen, Zhan-Wen Huang, Ming Liu, Jian-Qiang Wang, Liang Cai, Chun-Xiao Cao
Journal: Clinical Nuclear Medicine (2011)

Preoperative assessment of crossed circulation is prerequisite in successful surgical separation of conjoined twins. We describe 1 case of 4-month-old conjoined twins evaluated by hepatobiliary scintigraphy, which revealed no cross circulation between the twins. Both twins survived subsequent separation surgery.
TCT-309 Impact of Hyperuricemia on Coronary Artery Spasm as assessed with Intracoronary Acetylcholine Provocation Test
Authors: Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Raghavender Goud Akkala, Sunki Lee, Ji Bak Kim, Sung Il Im, Jin oh Na, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2013)
Abstract 276: Microtentacle stabilization during TGFβ-induced EMT as a new therapeutic target to reduce circulating tumor cell metastasis.
Authors: Jana Slovic, Michele I. Vitolo, Rebbecca A. Whipple, Amanda E. Boggs, Monica S. Charpentier, Lekhana Bhandary, Keyata Thompson, Stuart S. Martin
Journal: Cancer Research (2013)

Abstract Circulating tumor cells (CTCs) have been identified as a predictive factor of patient outcome and disease progression in breast cancer. Solid tumor metastasis involves detachment of epithelial cells into the lymphatics or vasculature, and the subsequent reattachment in distant tissues to establish new tumors at metastatic sites. Our lab has identified tubulin-based protrusions, termed microtentacles (McTNs), which facilitate tumor cell re-attachment and can penetrate endothelial layers to promote the retention of CTCs in distant tissues. In the current study, we examine the role of the physiological cytokine, TGFβ, in the cytoskeletal changes that promote McTN formation. McTNs are induced during the epithelial-to-mesenchymal transition (EMT) that accompanies tumor progression, and previous studies have shown that TGFβ can promote an EMT in a pathologic setting, despite its normal role as an anti-proliferative factor. When we treated MCF10A nontumorigenic mammary epithelial cells and MCF-7 breast tumor cells with TGFβ, immunoblotting demonstrated changes in protein expression consistent with an EMT, such as increased vimentin and N-Cadherin and decreased E-Cadherin expression. Alongside these typical EMT-induced protein expression changes, levels of detyrosinated α-tubulin (Glu-tubulin) also increased, which is a marker of stabilized microtubules that also promotes McTN formation. Furthermore, immunofluorescence demonstrated that Glu-tubulin was highly diffuse in untreated cells, but became organized into distinct cytoplasmic filaments upon treatment of cells with TGFβ. Detached MCF10A and MCF-7 cells also showed increased McTNs following exposure to TGFβ. Real-time measurement of cell reattachment by electrical impedance demonstrated that the increased McTNs associated with TGFβ treatment resulted in more efficient and faster cell reattachment. These results emphasize that the post-translational alterations in microtubules promoted by TGFβ can promote increased McTNs and that therapies targeting the molecular mechanisms underlying these TGFβ-induced cytoskeletal changes could provide new targets aimed at reducing CTC reattachment and metastasis. Citation Format: Jana Slovic, Michele I. Vitolo, Rebbecca A. Whipple, Amanda E. Boggs, Monica S. Charpentier, Lekhana Bhandary, Keyata Thompson, Stuart S. Martin. Microtentacle stabilization during TGFβ-induced EMT as a new therapeutic target to reduce circulating tumor cell metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 276. doi:10.1158/1538-7445.AM2013-276
SAT0441 Juvenile Onset Systemic Sclerosis: Clinical and Serological Features, and Mortality in Comparison with Adult Onset Disease
Authors: J. G. Ovalles-Bonilla, F. J. López-Longo, I. Monteagudo, E. Naredo, C. M. Gonzalez, I. de la Torre, M. Montoro, L. P. Martínez-Estupiñán, J. C. Nieto, J. Martínez-Barrio, M. Hinojosa, N. Bello, B. Serrano, C. Mata, L. Carreño
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Currently data regarding long-term outcome of juvenile systemic sclerosis (jSSc) is scarce. <h3>Objectives</h3> To describe the differences between patients with jSSc versus adult onset evaluated at a single medical center. <h3>Methods</h3> Patients with disease onset before the age of 17 years were included in the jSSc group, while subjects with SSc onset after age 18 formed the adult-onset cohort. The 2 groups were compared with respect to disease classification, clinical, serological data, and mortality. <h3>Results</h3> Seventeen jSSc cases seen between 1986 and 2011 were compared with 120 adult onset SSc cases. Mean age at onset in the jSSc group was 11.7±3.9 years, and the mean disease duration at the last follow-up was 19.3±7.8 years. The sex distribution was 7.5:1 (female:male). Among juvenile cases, 58.8% had diffuse SSc, while 41.2% had limited SSc. The clinical features seen in juvenile patients were: articular manifestations (arthralgia, arthritis, contractures and weakness) in the 100% of cases, Raynaud’s phenomenon in 94%, digital ulcers and telangiectasia in 53%, interstitial lung disease in 11.8%. Antinuclear antibody was positive in 100%, and anti-U1RNP in 64.7%. A global mortality of 17.6% was seen. Articular manifestations, anti-DNA and anti-U1RNP were seen more frequently in the jSSc group. Adult onset SSc develop a higher frequency of sclerodactyly and interstitial lung disease. <h3>Conclusions</h3> Diffuse SSc, limited SSc, calcinosis, digital ulcers, pulmonary hypertension, anti-centromere, anti-Scl-70 and mortality shows a similar distribution between the 2 groups. Patients with jSSc presented a lower frequency of interstitial lung disease and sclerodactyly, but a higher expression of anti-DNA and anti-U1RNP. <h3>Disclosure of Interest</h3> None Declared