tbuckley/cabot-search huggingface dataset:
PTH-205 Frequency and characteristics of pump alarms in patients on home parenteral nutrition
Authors: M Small, M Kallis, A Tsoukalis, JC Cascailh, SM Gabe
Journal: Gut (2015)

<h3>Introduction</h3> Infusion pumps play a key role in the life of patients on home parenteral nutrition. In addition to ensuring the accurate delivery of fluid, pre-set alarms alert patients to potential infusion or catheter related problems. Pumps have typically not permitted analysis of this information meaning that the nature and frequency of alarms is not known. Industry collaboration allowed the development of a unique system which would record details of the type and time of all pump alarms and send a notification email via a secure server to named healthcare professionals caring for the patient. The aim of this study was to identify the characteristics and rate of infusion alarms in a group of patients receiving home parenteral nutrition. <h3>Method</h3> 20 patients consented to have their infusions monitored. Any non intentional pump alarm (downstream occlusion, upstream occlusion, air in line or “other”, such as low battery, door open) generated a real time email alert outlining the time and nature of alarm to the secure email address of the lead investigator. <h3>Results</h3> 20 patients were monitored for 3 months. Patients infused an average of 5.3 ± 1.7 (2–7) nights per week. During the assessment period 922 email alerts were received, mean 46 ± 41.9 per patient, range 3–160. Adjusting for the number of nights patients infused this equated to a mean of 0.6 ± 0.6 alarms per infusion night. Patients experienced alarms on an average of 27 ± 0.21% of their infusion nights, range 4–76%. Only 1 patient (5%) experienced alarms on more than 75% of their infusion nights. 4 patients (20%) had alarms on less than 5% of their infusion nights. All patients had nights with no alarms. There was considerable variation in the largest number of alarms experienced per single infusion, mean 13.5 ± 19.8, range 1–93. There were significantly more downstream occlusions (n = 622) vs. upstream occlusions (n = 223), air in line (n = 37) or “other” (n = 35) alarms, p = 0.05. Of the “other” alarms, the most frequent was low battery (n = 25), followed by door open (n = 6) and an internal error code requiring maintenance (n = 4). The 2 patients with the highest occurrence of downstream alarms were the only patients that had ports. <h3>Conclusion</h3> This is the first time that the type and frequency of pump alarms in patients on home parenteral nutrition has been quantified. It demonstrates variation in the number of alarms patients receive, with some patients experiencing very few alarms. The technology provides valuable real time monitoring which could permit early intervention in identifying pump or infusion related problems. <h3>Disclosure of interest</h3> M. Small: None Declared, M. Kallis Paid Instructor for: Micrel Medical Devices, A. Tsoukalis Employee of: Micrel Medical Devices, J. Cascailh Employee of: Micrel Medical Devices, S. Gabe: None Declared.
OP0036 Comparison of Low- and High-Dose Rituximab for the Treatment of Rheumatoid Arthritis: An Updated Systematic Review and Meta-Analysis
Authors: M. Bredemeier, G.G.D. Campos, F.K. de Oliveira
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In a previous systematic review (1), our group found no significant differences in most efficacy outcomes between low- (2x500 mg or 1x1,000mg) and high-dose (2x1,000 mg) rituximab (RTX) for the treatment of rheumatoid arthritis (RA). <h3>Objectives</h3> To update a systematic review and meta-analysis of randomized controlled trials (RCTs) comparing low- and high-dose RTX for the treatment of RA, considering the full publication of 2 important studies (2, 3). <h3>Methods</h3> The systematic literature review searching for RCTs was updated to November 6, 2014 using the Embase, PubMed, Cochrane Library, and Web of Science databases, and hand searching. The primary outcomes were the American College of Rheumatology (ACR) criteria for 20% improvement (ACR20), ACR50, and ACR70 responses and the Disease Activity Score in 28 joints (DAS28) at 24 and 48 weeks. The secondary outcomes were the EULAR (European League against Rheumatism) moderate/good and good responses, the change in Health Assessment Questionnaire (HAQ) score, the change in the radiographic modified Total Sharp Score (mTSS), levels of immunoglobulin G (IgG), and safety outcomes. <h3>Results</h3> In total, 7 RCTs (2-8) were identified; 5 RCTs (2,5-8) were included in the meta-analysis of efficacy and safety outcomes. There were no significant differences in the primary outcomes, EULAR responses, and change in HAQ. Mean change in mTSS was 0.25 units (95%CI: 0.01 to 0.49; <i>P</i>=0.04) higher in low-dose group at the end of week 52. Two RCTs (3, 4) did not demonstrate difference between the RTX regimens for maintaining clinical response (obtained initially using high-dose RTX) in anti-TNF-experienced patients. IgG levels were significantly lower in the high-dose group at week 24 (<i>P=</i>0.02). The low-dose RTX group presented a significantly lower incidence of first infusion reactions (<i>P</i>=0.02). <h3>Conclusions</h3> Our updated results further support the similar efficacy of low- and high-dose RTX in different subsets of RA patients, despite a small difference in radiographic progression favoring high-dose RTX. The low-dose regimen demonstrated a better clinical and laboratory safety profile. <h3>References</h3> Bredemeier M et al. Arthritis Care Res (Hoboken) 2014;66:228–35. Peterfy C et al. Ann Rheum Dis 2014. Published Online First: 29 Oct 2014. doi:10.1136/annrheumdis-2014-206015. Mariette X et al. Ann Rheum Dis 2014;73:1508–14. Batticciotto A et al. Ann Rheum Dis 2013;72 (Suppl):877. Emery P et al. Arthritis Rheum 2006;54:1390-1400. Emery P et al. Ann Rheum Dis 2010;69:1629–35. Tak PP et al. Ann Rheum Dis 2012;71:351–7. Rubbert-Roth A et al. Rheumatology (Oxford) 2010;49:1683-93. <h3>Disclosure of Interest</h3> None declared
Gentamicin coating of plasma chemical oxidized titanium alloy prevents implant-related osteomyelitis in rats
Authors: M. Diefenbeck, C. Schrader, F. Gras, T. Mückley, J. Schmidt, S. Zankovych, J. Bossert, K.D. Jandt, A. Völpel, B.W. Sigusch, H. Schubert, S. Bischoff, W. Pfister, B. Edel, M. Faucon, U. Finger
Journal: Biomaterials (2016)
Exome Sequencing and Snp Array Reveal Epigenome Modifier Defects in Nasopharyngeal Carcinoma
Authors: Xuan Meng, De-chen Lin, Yasunobu Nagata, Yasuke Sato, Boon Cher Goh, Soo Chin Lee, Feng Gang Yu, Seishi Ogawa, Kwok Seng Loh, H.Phillip Koeffler
Journal: Annals of Oncology (2014)
Vagotomy for duodenal ulcer.
Authors: L Eckmann
Journal: BMJ (1972)

But the question is of substantial importance and should be answered.The policy for elderly hypertensives is more difficult to define.There is little point in treating very old patients with hypertension with the aim of preventing a long-term risk.Yet hypertension becomes more frequent as age advances.Only 0.2% of the 30-39-year-old age group have a diastolic pressure exceeding 110 mm Hg, but by the 60-69 decade 4-6% exceed this level.3Some would argue strongly that antihypertensive treatment offers elderly people the best chance of reducing the risk of strokes and the consequent misery and disability that goes with them.Clinical trials are needed to determine how effective and practical such treat- ment would be in older people.3
Male Histocompatibility Antigens In Mouse Endocrine Tissues: Functional and Histologic Evidence&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: R. F. Gittes, M.D., P. S. Russell, M.D.
Journal: JNCI Journal of the National Cancer Institute (1961)

We have sought evidence of the male-linked histocompatibility antigens in parathyroid, thyroid, and adrenal cortical tissue by assessing the fate of endocrine fragments from male donors placed as isografts into adult female mice (after preimmunization with or concomitantly with male skin isografts known to contain the antigens). Serial serum calcium assays in previously parathyroidectomized mice receiving intramuscular parathyroid fragments invariably provided clear functional evidence of the destruction of the buried male parathyroid tissue. Histologically a specific mononuclear cell inflammatory reaction was noted in male-to-female isografts of all three endocrine tissues, in striking contrast to the appearance of corresponding female-to-female control isografts. Thus male histocompatibility antigens are present in these endocrine tissues, and no deficiency in the activity of these antigens as compared to those of skin was demonstrable. Some immunological characteristics of these male antigens which may limit the applicability of these results to other mouse transplantation antigens are discussed.
Vaccines for Children Program, 1994
Authors: S B Nichols
Journal: JAMA (1994)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 34-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Sarah H. Cheeseman, Eugene J. Mark
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 10-year-old boy was admitted to the hospital because of jaundice.He was in a stable state of health until 22 months earlier, when a Coombs-positive hemolytic anemia was found; prednisone was required to maintain a satisfactory hematocrit level. Fifteen months before entry a splenectomy was performed, and the anemia resolved. One month later prednisone was discontinued, and 12 months before admission neutropenia was noted. At follow-up examination one month later neutropenia persisted, and mild thrombocytopenia was present. Microscopical examination of an aspirated specimen of bone marrow disclosed that it was hyper-cellular, and megakaryocytes were present. Prednisone . . .
An overview of current concepts of Alzheimer's disease
Authors: M K Schneck, B Reisberg, S H Ferris
Journal: American Journal of Psychiatry (1982)

The authors review the literature on Alzheimer’s disease, the major cause ofsenile dementia, and present a historical overview of senile dementia and its morbidity and mortality rates. They describe the clinicalfeatures of the various stages ofAlzheimer’s disease and discuss the differential diagnosis. They also describe the characteristic neuropathology and neurochemical abnormalities of the disease and their etiological implications. Finally, the authors discuss possible future directions for psychiatric research in the area ofAlzheimer’s disease.
Carbon Monoxide and Our Social Responsibility
Authors: E.J. H.
Journal: Annals of Internal Medicine (1973)

Editorial Notes1 July 1973Carbon Monoxide and Our Social ResponsibilityE.J. H.E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-1-129 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptElsewhere in this issue we have published a paper that reports an adverse effect of inhaled carbon monoxide on angina pectoris in patients with ischemic heart disease (seepage 000). The original version of this paper was read by the editors and reviewed critically by one expert in cardiovascular disease and two experts in respiratory and pulmonary physiology. Its publication was recommended by two of the consultants. The third consultant was against its publication. Nevertheless, we decided to publish the paper because we believe that the question it examines is very important, and we believe that its conclusions are supported... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 July 1973Volume 79, Issue 1Page: 129-130KeywordsAnginaCarbon monoxideCardiovascular diseasesCardiovascular physiologyCardiovascular therapyPulmonary diseasesRespiratory physiologyVentilators ePublished: 1 December 2008 Issue Published: 1 July 1973 PDF downloadLoading ...
GPs charged with manslaughter of 12 year old boy are acquitted
Authors: Clare Dyer
Journal: BMJ (2016)

Two GPs who were prosecuted for the manslaughter of a 12 year old patient have been acquitted after the judge presiding over the trial at Cardiff Crown Court ruled that there was no case for them to answer.

Lindsay Thomas, 42, and Joanne Rudling, 46, were charged with gross negligence manslaughter over the death of Ryan Morse from Addison’s disease on 8 December 2012. The prosecution argued that Ryan would have lived had either GP visited him or summoned an ambulance after a phone call the previous evening from his mother, Carol.1

But Justice Nicola Davies ruled at the end of the …
Clinical and Imaging Signs of Spondyloarthritis in First‐Degree Relatives of HLA–B27–Positive Ankylosing Spondylitis Patients: The Pre‐Spondyloarthritis (Pre‐SpA) Cohort Study
Authors: Maureen C. Turina, Janneke J. de Winter, Jacky E. Paramarta, Mihaela Gamala, Nataliya Yeremenko, Marita N. Nabibux, Robert Landewé, Dominique L. Baeten
Journal: Arthritis & Rheumatology (2016)

To investigate whether seemingly healthy first-degree relatives of patients with ankylosing spondylitis (AS) have clinical, laboratory, or imaging features of spondyloarthritis (SpA).First-degree relatives (ages 18-40 years) of HLA-B27-positive AS patients were included in the pre-spondyloarthritis (Pre-SpA) cohort, a prospective inception cohort study. Clinical, biologic, and imaging features were recorded. First-degree relatives were classified according to several sets of SpA classification criteria.We report baseline features of 51 first-degree relatives included in this study. Twenty-nine (57%) had back pain, 2 (4%) had psoriasis, 1 (2%) had inflammatory bowel disease, and 1 (2%) had uveitis. Three (6%) had low-grade sacroiliitis, 1 (2%) had cervical syndesmophytes on radiography, and 10 (20%) had bone marrow edema on magnetic resonance imaging of the sacroiliiac joints. Seventeen of 51 first-degree relatives (33%) fulfilled SpA classification criteria: 7 (14%) fulfilled both Assessment of SpondyloArthritis international Society (ASAS) axial SpA and European Spondylarthropathy Study Group (ESSG) classification criteria, 6 (12%) fulfilled only ASAS axial SpA classification criteria, and 4 (8%) fulfilled only ESSG classification criteria; 3 (6%) also fulfilled the Amor criteria. None fulfilled other SpA classification criteria. First-degree relatives fulfilling the ASAS axial SpA and/or ESSG classification criteria had more frequent inflammatory back pain, had a higher level of disease activity, and had more psoriasis. No differences were found in parameters of inflammation, peripheral and extraarticular disease other than psoriasis, and HLA-B27 positivity between those who did and those who did not fulfill the ASAS axial SpA and/or ESSG classification criteria. Four first-degree relatives (12%) who did not fulfill the ASAS axial SpA and/or ESSG classification criteria had imaging abnormalities suggestive of SpA.A substantial proportion of seemingly healthy first-degree relatives of HLA-B27-positive AS patients have clinical and/or imaging abnormalities suggestive of SpA. Thirty-three percent could be classified as having SpA. Further follow-up will show which first-degree relatives will develop clinically manifest SpA.
Ensuring safety of home-produced eggs to control salmonellosis in Poland: lessons from an outbreak in September 2011
Authors: A Zielicka-Hardy, D Zarowna, J Szych, G Madajczak, M Sadkowska-Todys
Journal: Eurosurveillance (2012)

Implementation of control measures in line with European Commission regulations has led to a decrease in salmonellosis in the European Union since 2004. However, control programmes do not address laying hens whose eggs are produced for personal consumption or local sale. This article reports an investigatxion of a salmonellosis outbreak linked to home-produced eggs following a family event held in a farm in September 2011 near Warsaw, Poland. In the outbreak, 34 people developed gastroenteritis symptoms. Results from a cohort study indicated a cake, prepared from raw home-produced eggs, as the vehicle of the outbreak. Laboratory analysis identified Salmonella enterica serotype Enteritidis (S. Enteritidis) in stool samples or rectal swabs from 18 of 24 people and in two egg samples. As no food items remained, we used phage typing to link the source of the outbreak with the isolated strains. Seven S. Enteritidis strains analysed (five from attendees and two from eggs) were phage type 21c. Our findings resulted in culling of the infected laying hens and symptomatic pigeons housed next to the hens. Salmonella poses as a public health problem in Poland: control measures should not forget home-produced eggs, as there is a risk of infection from their consumption.
Public preferences for vaccination programmes during pandemics caused by pathogens transmitted through respiratory droplets – a discrete choice experiment in four European countries, 2013
Authors: Domino Determann, Ida J Korfage, Angela Fagerlin, Ewout W Steyerberg, Michiel C Bliemer, Helene A Voeten, Jan Hendrik Richardus, Mattijs S Lambooij, Esther W de Bekker-Grob
Journal: Eurosurveillance (2016)

This study aims to quantify and compare preferences of citizens from different European countries for vaccination programme characteristics during pandemics, caused by pathogens which are transmitted through respiratory droplets. Internet panel members, nationally representative based on age, sex, educational level and region, of four European Union Member States (Netherlands, Poland, Spain, and Sweden, n = 2,068) completed an online discrete choice experiment. These countries, from different geographical areas of Europe, were chosen because of the availability of high-quality Internet panels and because of the cooperation between members of the project entitled Effective Communication in Outbreak Management: development of an evidence-based tool for Europe (ECOM). Data were analysed using panel latent class regression models. In the case of a severe pandemic scenario, vaccine effectiveness was the most important characteristic determining vaccination preference in all countries, followed by the body that advises on vaccination. In Sweden, the advice of family and/or friends and the advice of physicians strongly affected vaccine preferences, in contrast to Poland and Spain, where the advice of (international) health authorities was more decisive. Irrespective of pandemic scenario or vaccination programme characteristics, the predicted vaccination uptakes were lowest in Sweden, and highest in Poland. To increase vaccination uptake during future pandemics, the responsible authorities should align with other important stakeholders in the country and communicate in a coordinated manner.
Pancreatic Extracts
Authors: Armand Littman, Donald H. Hanscom
Journal: New England Journal of Medicine (1969)

TREATMENT with pancreatic extracts has the single purpose of correcting the deficits resulting from an absolute or relative deficiency of exocrine pancreatic secretion. This article will review the goals to be accomplished, the quality of the preparations available and ways to give them to adults with pancreatic deficiency.Goals of TherapyWhen 80 per cent or more of pancreatic function is lost, steatorrhea and azotorrhea occur without significant impairment of carbohydrate digestion. Ideally, the aim for replacement therapy is to restore digestion and absorption to normal with tolerable doses of pancreatin. This goal is often difficult or impossible to attain, . . .
AB1035 Compliance to Colchicine Treatment and Disease Activity in Familial Mediterranean Fever (FMF) Patients in Middle/Black Sea Region of Turkey (In Çorum Region)
Authors: Y. Karaaslan, I. Dogan, A. Omma, S. Can Sandıkçı
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Colchicine is the gold standard treatment for prevention of inflammatory attacks and prevention of reactive amyloidosis in FMF. However, noncompliance to colchicine treatment is common among FMF patients. On the other hand, the disease may not be controlled in some patients despite use of full dose colchicine. In this study, we aimed to investigate the rates of disease control, compliance to colchicine treatment, and need for an additional treatment despite use of full dose colchicine in patients with FMF in Çorum region where FMF is common in Turkey. <h3>Objectives</h3> The patients with FMF who admitted to Rheumatology Clinic established 1 year ago in a tertiary medical center located in Corum province, and followed up with the diagnosis of FMF for at least 6 months were analyzed. <h3>Methods</h3> A total of 96 consecutive patients who admitted to our center in last 3 months, fulfilled Tel-Hashomer FMF diagnostic criteria, and on colchicine treatment were included in the study. <h3>Results</h3> The mean age of the patients was 33.1±10.8 years, female/male ratio was 65/31, and the mean disease duration was 20.6±14.4 years. 39.6% of the patients included in the study had at least three or more attack in last 12 months (2.2% of the patients had 25 or more attack, 4.2% patients had 12-24 attack, 18.8% patients had 5-11 attack and 11.5% patients had 3-4 attack in last 12 months). The mean attack frequency in last 12 months was determined 3.2. The levels of acute phase reactants were high in 27.3% of the patients examined in attack free period. 4.2% patients had markedly proteinuria. Use of colchicine was very regular (&gt;90%) in 38.5%, predominantly regular (75-90%) in 26%, and moderately regular (50-74%) in 21.9% of the patients while 8.3% of the patients reported that they used colchicine sometimes, or only during attacks (&lt;50%). 5.3% of them reported that they did not use the agent or stopped using it. At least one side effect of colchicine was reported by 16.6% of the patients. Frequency order of the reported side effects were as follows: Increased liver enzymes 9.4%, diarrhea 2.1%, abdominal pain 2.1%, myopathy 1%, and other 3.1%. Despite very regular (&gt;90%) use of colchicine, 10.8% of the patients reported at least 3 or more attack in last 12 months, and 16.2% of the patients had high acute phase reactant levels in attack free period. 1 patients were on anti-IL-1 antagonist treatment. <h3>Conclusions</h3> In real life, the disease was not under control in 39.6% of FMF patients who used colchicine. 35.5% of FMF patients did not use the drug regularly, and an additional treatment was needed in 10.8% of the patients despite regular use of the agent in a region of Turkey where FMF is common (in Çorum region) <h3>Disclosure of Interest</h3> None declared