tbuckley/cabot-search huggingface dataset:
AB0776 Examination of changes in the prognosis and prognostic factors of microscopic polyangitis in japan
Authors: T. Shoda, T. Takeuchi, T. Kotani, K. Nagai, D. Wakura, K. Isoda, S. Yoshida, K. Hata, S. Makino, T. Hanafusa
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> We investigated changes in the prognosis and prognostic factors with respect to remission induction therapy in patients with microscopic polyangitis (MPA). <h3>Methods</h3> Among patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) in whom remission was induced in our hospital between 1995 and 2010, the subjects were 60 who were regarded as having MPA according to the classification algorithm established by Watte et al. (2007) (1). We compared the prognosis during the remission induction period between two groups: patients in whom remission was induced between 1995 and 2004, and those in whom remission was induced between 2005 and 2010. In addition, we analyzed prognostic factors in the early phase of treatment. <h3>Results</h3> The subjects consisted of 23 males and 37 females. The median age (IQR) was 71 years (range: 59 to 75 years). According to EUVAS' severity classification of AAV(2), the lesion type was evaluated as localized in 4 patients, early systemic in 7, systemic in 26, and severe/refractory in 23 (2 with cerebral hemorrhage, 2 with hemorrhage of the digestive tract, 1 with pancreatitis, 10 with diffuse pulmonary hemorrhage, and 2 who were positive for anti-basement-membrane antibody). Using the Kaplan-Meier life table method, the 180-day survival rate was estimated to be 79%. However, after 2004, it improved to 90%. When analyzing prognostic factors using Cox's proportional hazard model, there were significant differences in the BVAS score and rate of decrease in the ANCA level between survival and primary disease-related death groups. <h3>Conclusions</h3> With respect to remission induction therapy for MPA, the prognosis after was more favorable than before 2004. When examining prognostic factors, the results suggest that BVAS-based assessment and control of the rate of decrease in the ANCA level are useful. <h3>References</h3> Watts R, Lane S, Hanslik T, et al: Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies. Ann Rheum Dis 2007; 66:222-227. Mukhtyar C, Guillevin L, Cid MC, et al: EULAR recommendations for the management of primary small and medium vessel vasculitis. Ann Rheum Dis 2009; 68: 310-317. <h3>Disclosure of Interest</h3> None Declared
Abstract 4859: Statin-induced autophagy in prostate cancer cells
Authors: Ankur Parikh, Chandra Childress, Qiong Lin, Daniel Rukstalis, Wannian Yang
Journal: Cancer Research (2010)

Abstract Statins, a class of inhibitors of 3-hydroxyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase, are commonly prescribed medications for treatment of hypercholesterolemia. Epidemiological studies have shown that statin use decreases the incidence of advanced prostate cancer. Here we report that atorvastatin (Lipitor), a broadly prescribed statin, induces autophagy and rapid cell death in androgen receptor (AR)-negative prostate cancer PC3 cells. Atorvastatin treatment of PC3 cells for 40 hrs increased expression of LC3-II by more than 10 fold in a dose-dependent manner. Treatment of the cells with pepstatin A and E64-d, the autophagic protease inhibitors, dramatically increased atorvastatin-dependent LC3-II expression level, indicating that atorvastatin induced autophagic flux. In addition, atorvastatin treatment caused rapid death of PC3 cells. Atorvastatin-induced autophagy and rapid cell death were reversed by addition of geranylgeraniol, not farnesol, in culture medium, indicating that atorvastatin-mediated inhibition of geranylgeranyl biosynthesis causes autophagy and cell death. Furthermore, atorvastatin did not induce autophagy or cell death in normal prostate RWPE1 cells and induced only a minor autophagic response in AR-positive prostate cancer LNCaP cells. Thus, our studies demonstrate that statins induce autophagy and autophagy-associated cell death in PC3 cells, likely through inhibition of geranylgeranylation, and suggest that autophagic response to statins may partially underlie the protective effects of statins on prostate cancer. Importantly, these findings highlight additional mechanisms by which statins might be used for therapy of prostate cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4859.
Abstract 4950: miR-326 is critical for VEGF-C induced CTTN expression and metastasis of esophageal squamous cell carcinoma
Authors: Jean Chiou, Chih-Chun Lin, Yi-Hua Jan, Michael Hsiao, Jen-Liang Su
Journal: Cancer Research (2011)

Abstract Esophageal cancer is a major cause of cancer deaths in most Asian countries, which is so called Asian esophageal cancer belt. Recent studies have demonstrated that, Cortactin (CTTN), a cytoskeletal protein frequently overexpressed in many types of human cancers including esophageal squamous cell carcinomas. Animal studies suggest that CTTN overexpression increases esophagus tumor aggressiveness, possibly through promotion of tumor invasion and metastasis. Vascular endothelial growth factor (VEGF)-C, ligand for the VEGF receptor-3, is critical for cancer metastasis through induces the formation of tumor-associated lymphatic vessels and facilitate the mobility of tumor cells. However, the detail molecular mechanisms involved in VEGF-C/VEGFR-3 axis-mediated tumor progression is not clear yet. Besides, the biological significance of the correlation between VEGF-C and CTTN in cancer cells is completely unknown. In this study, we found CTTN is critical for VEGF-C-mediated migration and invasion of esophageal squamous cell carcinoma (ESCC) cells. We also found that miR-326, which could target the 3’UTR of CTTN, is involved in VEGF-C-induced CTTN expression and subsequent migration and invasion of ESCC cells through an Src-dependent pathway. Taken together, our results show that VEGF-C up-regulates CTTN protein expression, resulting in enhanced cell invasion, tumorgenesis and metastasis through Src-mediated down-regulation the expression of miR-326. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4950. doi:10.1158/1538-7445.AM2011-4950
IL-2 Approval Recommended by FDA Panel
Authors: R. Scott
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article IL-2 Approval Recommended by FDA Panel Get access Robert Scott Robert Scott Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 4, 19 February 1992, Pages 226–227, https://doi.org/10.1093/jnci/84.4.226-a Published: 19 February 1992
Abstract 5104: Identification of key tumorigenic pathways in pancreatic adenocarcinoma patients using massively parallel DNA and RNA sequencing
Authors: Winnie S. Liang, David W. Craig, John Carpten, Mitesh J. Borad, Michael J. Demeure, Glen J. Weiss, Jeffrey A. Kiefer, Richard Posner, Galen H. Hostetter, Tyler Izatt, Shripad Sinari, Alexis Christoforides, Jessica Aldrich, Ahmet Kurdoglu, Lori Phillips, Hollie Benson, Angela Baker, Haiyong Han, Douglas Lake, Edward C. Stites, Ramesh K. Ramanathan, Rafael Fonseca, A. Keith Stewart, Daniel Von Hoff
Journal: Cancer Research (2012)

Abstract Purpose: Pancreatic adenocarcinoma is among the most lethal forms of all malignancies. While significant research has implicated multiple genes in disease pathogenesis, identification of therapeutic leads has been difficult. The majority of currently available therapies provide only marginal benefit. To address this issue, our goal was to assess global somatic events across multiple pancreatic tumors by using next-generation sequencing technologies (NGS). Experimental Design: We performed whole genome sequencing (WGS) on paired tumor and normal samples from 3 pancreatic adenocarcinoma patients. Additionally, we performed whole transcriptome sequencing (WTS) on 2 of these patients’ tumors for which tumor RNA was available. Results: We generated on average 132 billion mappable bases across all patients using WGS, and identified 140 somatic coding events including point mutations, insertion/deletions, and chromosomal copy number variants. Data from WGS and WTS were integrated and analyzed to identify the most heavily affected pancreatic cancer pathways across all patients. The KRAS signaling pathway was identified as the most significant map. Unbiased global pathway analysis was also performed to identify processes that may be impacted. Consistent with the previous analysis, the most significant pathway from this analysis is also KRAS signaling. This integrated analysis specifically identifies heavily affected pathways in pancreatic cancer and pinpoints genes and processes that may be considered as targets for more effective therapies. Conclusions: While sequencing of additional patients is necessary to strengthen selection of key pathways, we demonstrate the utility of using NGS to understand the processes driving pancreatic adenocarcinoma so that standardized treatments for patients may be improved. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5104. doi:1538-7445.AM2012-5104
Utilisation des prothèses coliques en pathologie tumorale dans les hôpitaux généraux. Etude rétrospective dans 4 centres en 2009–2010
Authors: V Quentin, J Baudon, D Grasset, L Falize, O Nouel
Journal: Endoscopy (2012)

L'usage de la prothèse colique est maintenant largement diffusé. Cependant il pourrait exister des différences entre les résultats des publications internationales et la pratique courante. L'objectif principal de cette étude était d'évaluer les pratiques de pose de prothèses coliques dans les centres hospitaliers généraux sur la période 2009–2010.
India must make cancer care more affordable and accessible, says commission
Authors: C. Travasso
Journal: BMJ (2014)

India needs to make cancer care more affordable, increase its healthcare workforce, and deal with socio-cultural barriers to cancer control, to improve the diagnosis of cancer and access to care, a commission has said. 

The commission, which reported in Lancet Oncology , also called for India to establish cancer registries, develop regional and national cancer plans, increase its spending on healthcare and research, develop tumour banks and clinical databases, and tailor programmes to deal with the needs of its rural and urban populations.1

About 2.5 million people in India live with an existing diagnosis of cancer, and 0.55 million die from the disease every year, with most deaths (71%) among those aged 30-69. Although the risk of getting cancer before age 75 is only 10% in India …
Does it talk the talk? On the role of basal ganglia in emotive speech processing
Authors: Uri Hasson, Daniel A. Llano, Gabriele Miceli, Anthony Steven Dick
Journal: Behavioral and Brain Sciences (2014)

Abstract Ackermann et al.'s phylogenetic account of speech argues that the basal ganglia imbue speech with emotive content. However, a body of work on auditory/emotive processing is inconsistent with attributing this function exclusively to these structures. The account further overlooks the possibility that the emotion-integration function may be at least in part mediated by the cortico-ponto-cerebellar system.
Unilateral Ga-67 Uptake in the Hemithorax After Recurrence of Pleural Effusion
Authors: GEORGE PANOUTSOPOULOS, KONSTANTINOS SYRIGOS, IOANNIS ILIAS, CHRISTOS BATSAKIS, IOULIA CHRISTAKOPOULOU
Journal: Clinical Nuclear Medicine (2001)

PANOUTSOPOULOS, GEORGE M.D.; SYRIGOS, KONSTANTINOS M.D.; ILIAS, IOANNIS M.D.; BATSAKIS, CHRISTOS M.D.; CHRISTAKOPOULOU, IOULIA M.D. Author Information
Atherosclerotic Burden and Heart Failure After Myocardial Infarction
Authors: Yariv Gerber, Susan A. Weston, Maurice Enriquez-Sarano, Sheila M. Manemann, Alanna M. Chamberlain, Ruoxiang Jiang, Véronique L. Roger
Journal: JAMA Cardiology (2016)

Whether the extent of coronary artery disease (CAD) is associated with the occurrence of heart failure (HF) after myocardial infarction (MI) is not known. Furthermore, whether this association might differ by HF type according to preserved or reduced ejection fraction (EF) has yet to be determined.To evaluate in a community cohort of patients with incident (first-ever) MI the association of angiographic CAD with subsequent HF and to examine the prognostic role of CAD according to HF subtypes: HF with reduced EF and HF with preserved EF.A population-based cohort study was conducted in 1922 residents of Olmsted County, Minnesota, with incident MI diagnosed between January 1, 1990, and December 31, 2010, and no prior HF; study participants were followed up through March 31, 2013. The extent of angiographic CAD was determined at baseline and categorized according to the number of major epicardial coronary arteries with 50% or more lumen diameter obstruction.The primary end point was time to incident HF. The primary exposure variable was the extent of CAD as expressed by the number of major coronary arteries with significant obstruction (0-, 1-, 2-, or 3-vessel disease) obtained from coronary angiograms performed no more than 1 day after the MI. Heart failure was ascertained by the Framingham criteria and classified by type according to EF (50% cutoff).Of the 1922 participants, 1258 (65.4%) were men (mean [SD] age, 64 [13] years). During a mean follow-up period of 6.7 (5.9) years, 588 patients (30.6%) developed HF. With death and recurrent MI modeled as competing risks, the cumulative incidence rates of post-MI HF among patients with 0 or 1, 2, and 3 diseased vessels were 10.7%, 14.6%, and 23.0% at 30 days; and 14.7%, 20.6%, and 29.8% at 5 years, respectively (P < .001 for trend). After adjustment for clinical characteristics in a Cox proportional hazards regression model, the hazard ratios (95% CIs) for HF were 1.25 (0.99-1.59) and 1.75 (1.40-2.20) in patients with 2 and 3 vessels vs 0 or 1 occluded vessel, respectively (P < .001 for trend). The increased risk with a greater number of occluded vessels was independent of the occurrence of a recurrent MI and did not differ appreciably by HF type.The extent of angiographic CAD is an indicator of post-MI HF regardless of HF type and independent of recurrent MI. These data underscore the need to further investigate the processes taking place in the transition from myocardial injury to HF.
ASSOCIATION OF NON-HIGH DENSITY LIPOPROTEIN-CHOLESTEROL WITH CAROTID INTIMA-MEDIA THICKNESS AND CARDIOVASCULAR EVENS IN MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS
Authors: Alexandros Briasoulis, Fayez Siddiqui, Issa Alesh, Anupama Kottam, Luis Afonso
Journal: Journal of the American College of Cardiology (2015)
Abstract 718: microRNA-29a* is a predictor for early recurrence hepatitis B virus-related hepatocellular carcinoma after surgical resection
Authors: Hai-Tao Zhu, Qiong-Zhu Dong, Yuan-Yuan Sheng, Jin-Wang Wei, Guan Wang, Hai-Jun Zhou, Ning Ren, Hu-Liang Jia, Qing-Hai Ye, Lun-Xiu Qin
Journal: Cancer Research (2012)

Abstract Purpose: Early tumor recurrence after liver resection for hepatocellular carcinoma (HCC) was mainly due to intrahepatic tumor spreading. In this study, we set out to identify specific microRNA (miRNA) which might be used in predicting the possibility of early recurrence after HCC resection. Experimental Design: Taqman low density arrays were used to detect the miRNA expression levels in both the microdissected tumorous and adjacent non-tumorous liver tissues from 20 HCC patients. Quantitative real-time PCR (qRT-PCR) was used to verify the findings in 106 patients, and to develop a predictive assay. The identified miRNAs were further validated in an independent cohort of 112 patients. Results: Thirty seven selected miRNAs were validated in 106 HCC patients using qRT-PCR. A significant association was found between miR-29a* level in HCC tissues and early recurrence (P=0.0002). This association was further confirmed in the independent testing set of 112 patients (P=0.0154), in which miR-29a* level was significantly associated with both time to tumor recurrence (TTR) (P=0.0015) and overall survival (OS) (P=0.0079) of patients. In the univariate and multivariate analyses, miR-29a* was identified as an independent factor for TTR, particularly for those patients with early stage of HCC. The sensitivity and specificity of miR-29a* for the prediction of early HCC recurrence in an independent blinded validation set reached 74.2% and 68.2%, respectively. Conclusion: MiR-29a* might be a useful marker for prediction of early recurrence of HCC, particularly for those with early stage of HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 718. doi:1538-7445.AM2012-718
FRI0286 Diffuse alveolar hemorrhage in patients with systemic lupus erythematosus. a subgroup analysis.
Authors: M. U. Martinez-Martinez, J. Alcocer-Varela, F. J. Merayo-Chalico, J. D.J.E. Gómez-Bañuelos, M. A. Saavedra, S. Enciso-Peláez, E. Faugier-Fuentes, R. Maldonado-Velázquez, L. M. Suárez-Larios, D. Vega-Morales, A. Abril, R. Butendieck, F. Irazoque-Palazuelos, C. Abud-Mendoza
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication in systemic lupus erythematosus (SLE). It is associated with a high mortality rate. Pathogenesis of DAH in patients with SLE includes disease activity; however, infection was demonstrated in more than 50% in other case series. <h3>Objectives</h3> To evaluate subgroups in a large retrospective cohort of SLE patients with DAH. <h3>Methods</h3> This retrospective cohort included 57 patients with SLE and DAH from 8 hospitals. We evaluated clinical, laboratory and treatment data. All patients met the American College of Rheumatology classification criteria for SLE. DAH was defined according to the presence of sudden drop of hemoglobin of at least 1.5 g/dL without other sources of bleeding, new infiltrates on chest radiograph and at least one of the following pulmonary symptoms: hemoptysis, dyspnea, or tachycardia. Non-parametric statistics were performed; categorical variables were compared with X<sup>2</sup> or exact Fisher-test. <h3>Results</h3> We included 57 patients with DAH and SLE, 49 (86%) were women, 14 (24.6%) children, and 24 (42.1%) died. Twenty two patients (38.6%) were diagnosed with infection (8 invasive fungal infections, 21 bacterial infections, 7 patients had mixed infections). Factors associated with mortality were: high disease activity (relative risk (RR)=2.1, confidence interval (CI): 1.1-4.1, p=0.0239), glomerular filtration rate less than 60 ml/min/1.72 m<sup>2</sup> (RR: 2.5, CI: 1.2-5.1, p=0.0052), mechanical ventilation (RR: 7.5, CI: 1.1-50.5, p-value= 0.002), infections (1.9, CI: 1.03- 3.5, p=0.04) and specifically fungal infections (RR: 2.0, CI: 1.2-3.5, p= 0.04). There were no differences in mortality rates between children and adults. Table 1 shows factors associated with infection, and that SLE treatment naïve as a "protective" factor. <h3>Conclusions</h3> DAH in SLE patients is frequently associated with infection; our series describes a subgroup analysis of this rare manifestation of SLE. Factors associated with infection can indicate therapeutic choice for the rheumatologists in SLE patients with DAH. <b>Disclosure of Interest</b>: None Declared
SAT0328 What Happens to Kellgren-Lawrence Grade 1 Joints in Hand OA After 2.6 Years ? OA or not OA “That is the Question” ? - Data from the Sekoia Trial
Authors: E. Maheu, C. Cadet, F. Carrat, Y. Barthe, F. Berenbaum
Journal: Annals of the Rheumatic Diseases (2013)

Thoracal sympatectomy for hyperhidrosis and vasospastic vascular diseases is a rare method of surgical treatment. Three patients (1 male, 2 female; mean age 27.6; between 25 and 30) with palmar hyperhidrosis and/or axillary and dorsal hyperhidrosis who underwent single port thoracoscopic sympatectomy were analysed for age, sex, time of operation room, intraoperative and postoperative complications and length of hospital stay. Mean operating room time was 70 min (between 30 and 120 min). Mean length of hospital stay was 1 day. No postoperative complications were noted. Single incision laparoscopic surgery for hyperhidrosis is a safe method of treatment and an alternative to laparoscopy.
AB0677 Late onset systemic lupus erythematosus: Is it actually a milder variant?
Authors: J.G. Ovalles-Bonilla, J. Martínez-Barrio, F. Lόpez-Longo, I. de la Torre, C. González, L. Valor, M. Montoro-Άlvarez, F. Aramburu, C. Marín, L. Martínez-Estupiñán, J. Nieto, M. Hinojosa, N. Bello, I. Monteagudo, L. Carreño
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To describe the clinical and immunological features, the damage accrual and mortality of late onset compared with adult onset SLE. <h3>Methods</h3> The data was obtained from a long term prospective cohort of 353 patients diagnosed with SLE in the Rheumatology Department of Gregorio Marañon Hospital in Madrid, Spain. Demographic, clinical, and laboratory data were collected at disease onset and during it's course from 1986 to 2006. Patients were divided into 2 groups: adult onset 19-49 years (n=276) and late onset ≥50 years (n=77). Organ damage was scored using the Systemic Lupus International Collaborative Clinics/American College of Rheumatology (SLICC/ACR) Damage Index. <h3>Results</h3> A total of 353 patients were recruited, with a following mean time of 11 years. The female to male ratio differed significantly (p=0.005) between groups. At diagnosis, the late-onset group presented cutaneous manifestations less frequently (p&lt;0.001). During follow-up, the late-onset group presented a lower incidence of arthritis (p=0.02), malar rash (p=0.001), photosensitivity (p=0.04), fever (p=0.03), low serum complement (p=0.001), hematologic (p=0.03) and renal (p=0.01) manifestations. The late-onset group had significantly more hypertension (p=0.03), neoplasms (p=0.02), damage accrual (p=0.007) and mortality (p=0.006). As for autoantibody profile, no statistically significant differences were found. <h3>Conclusions</h3> Late onset SLE is clinically different with less arthritis, fever, low serum complement, cutaneous, hematologic and renal manifestations compared with the adult onset group. The higher frequency of damage accrual, mortality and hypertension observed in the late-onset group can be affected by aging-related factors other than disease activity or duration. <h3>Disclosure of Interest</h3> None Declared
Studies of Acute Respiratory Illnesses Caused by Respiratory Syncytial Virus
Authors: Charles M. Reilly, Joseph Stokes, Laurella McClelland, David Cornfeld, Vincent V. Hamparian, Albert Ketler, Maurice R. Hilleman
Journal: New England Journal of Medicine (1961)

THE introduction of tissue-culture technology into the field of viral infections has permitted rapid progress, in the past decade, in the etiologic definition of the acute respiratory illnesses of man. Specific etiologic designation, in turn, allows precise definition of the spectrum of clinical disease resulting from infection with a particular virus.The respiratory syncytial virus, initially designated chimpanzee-coryza agent (CCA), was first recovered by Morris et al.1 from chimpanzees with respiratory illness and from a laboratory worker. The virus was recovered later by Chanock and his associates2 , 3 from infants with lower-respiratory-tract disease and from "controls." Rowe and Michaels4 isolated the . . .