tbuckley/cabot-search huggingface dataset:
Endoscopic resection and enucleation of gastric submucosal tumor facilitated by subsequent closure of incision using over-the-scope clip
Authors: Seiichiro Abe, Leona Council, Xaoiyan Cui, Yutaka Saito, Klaus Mönkemüller
Journal: Endoscopy (2015)

A 73-year-old man with a history of diabetes mellitus, hypertension, coronary artery disease, and atrial fibrillation was found to have a 20-mm reddish elevated lesion of the lower gastric body ([Fig. 1 a]). Endoscopic ultrasound revealed a submucosal tumor originating from the muscularis propria. The patient preferred an endoscopic excision. An endoluminal resection was performed using the endoscopic submucosal dissection (ESD) technique with carbon dioxide insufflation. An indigo carmine-saline mixture was injected into the base of the lesion. After creation of incision with the tip of a snare, the IT-knife2 (Olympus, Melville, New York, United States) was then used to circumferentially cut the mucosa and submucosa around the tumor. Careful dissection was performed, exposing the entire capsulized round tumor, which was completely excavated from its base and enucleated ([Fig. 1 b]). The resection was deep exposing the muscle layer. Given the patient's high risk cardiovascular status and continued need for antiplatelet agents, the wound was closed endoscopically using an over-the-scope clip (OTSC; 12/6 t, Ovesco, Tübingen, Germany). Air was suctioned from the stomach to decrease the surface area of the wound. Then the OTSC device was directed towards the wound and suction was applied to pull the lateral mucosa edges into the cap. The clip was released and the wound closed successfully ([Fig. 1 c]). The patient was discharged home and did well. The resected specimen confirmed enucleation of the gastric leiomyoma ([Fig. 1 d]).
PWE-059 Incidence of endoscopically and histologically confirmed ileal ulceration in a sequential cohort of patients undergoing screening colonoscopy as part of the uk bowel cancer screening programme
Authors: MJ McDonnell, S Burningham, A Al Badri, JN Gordon
Journal: Gut (2015)

<h3>Introduction</h3> The incidence of ileal ulceration in patients presenting for colonoscopy within the UK Bowel Cancer Screening Programme (BCSP) is unknown. Terminal ileal intubation is not a prerequisite of the programme and usually not performed on a systematic basis. Anecdotally we became aware that ileal ulceration was a surprisingly common finding. We therefore decided to prospectively evaluate the incidence of ileal ulceration in sequential patients presenting for colonoscopy through the BCSP. <h3>Method</h3> All sequential patients being endoscoped by a single BCSP colonoscopist over a 28 month period from July 2012 were prospectively audited. All patients had been referred for colonoscopy on account of positive FOBs performed as part of the UK BCSP. Terminal ileal intubation was planned at the outset in all cases. If ileal ulceration was seen it was photographed and biopsied. Current symptoms, past medical and drug history was recorded in all cases. Histology was reported by BCSP pathologists, with all cases of ileal ulceration subsequently reviewed by a specialist GI pathologist. <h3>Results</h3> 351 sequential colonoscopies performed by a single BCSP colonoscopist (JNG). Terminal ileal intubation was achieved in 325/351 (92.6%) of cases. Endoscopic evidence of terminal ileal ulceration was found in 28/325 (8.6%) of cases where the ileum was intubated. Ulceration was confirmed on biopsy in 24/325 (7.4%) cases. 2/24 cases had previously diagnosed Crohn’s disease (1 on active follow-up, the other historical). 5/24 patients were taking regular NSAIDS. The remaining 17/325 (5.2%) with both endoscopic and histological evidence of terminal ileal ulceration had no known risk factors. <h3>Conclusion</h3> In this study, endoscopically and histologically confirmed ileal ulceration was a common finding occurring in 7.3% of cases. This is the first study to document these findings prospectively in a sequential cohort of BCSP patients where intubation of the terminal ileum was attempted in a systematic manner. The incidence is dramatically higher than that previously reported in non-BCSP cohorts. Some cases can be attributed to drug use with the remainder appearing likely to be either physiological or potentially represent Crohn’s disease. The clinical relevance of these findings is currently unknown though it is pertinent that many patients in this cohort either had symptoms or had been previously been investigated for IBS or a change in bowel habit. <h3>Disclosure of interest</h3> None Declared.
Therapy-related acute leukemia associated with t(11q23) after primary acute myeloid leukemia with t(8;21): a report of two cases [letter]
Authors: D Roulston, J Anastasi, R Rudinsky, G Nucifora, N Zeleznik-Le, JD Rowley, L McGavran, M Tsuchida, Y Hayashi
Journal: Blood (1995)
Graduate Medical Education
Authors: J E McCORMACK
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Topography of Chronic Gastritis in Cancer-Bearing Stomachs<xref ref-type="fn" rid="fn1"><sup>1</sup></xref><xref ref-type="fn" rid="fn2"><sup>2</sup></xref>
Authors: Robert Hebbel, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article The Topography of Chronic Gastritis in Cancer-Bearing Stomachs Get access Robert Hebbel, M. D. Robert Hebbel, M. D. Department of Pathology, University of Minnesota, Minneapolis Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 505–522, https://doi.org/10.1093/jnci/10.2.505 Published: 01 October 1949
AB1149 A Simple Assessment of Psychological Distress in Rheumatoid Arthritis Patients Using Multidimensional Health Assessment Questionnaire (MDHAQ): A Validation Study of Psychological MDHAQ: Table 1.
Authors: N. Yokogawa, T. Kaneko, Y. Nagai, T. Nunokawa, T. Sawaki, K. Shiroto, K. Shimada, S. Sugii
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Multidimensional Health Assessment Questionnaire (MDHAQ) was designed to assess quality of life impairment including psychological distress in rheumatoid arthritis (RA) patients. In addition to ten questions dealing with the patient9s physical activity (Q1-10), MDHAQ also includes the following three questions, which address the psychological state of the patient: “Get a good night9s sleep?” (Q11), “Deal with feelings of anxiety or being nervous?” (Q12), and “Deal with feelings of depression or feeling blue?” (Q13) [1]. The utility of these questions in daily clinical practice has not been described. <h3>Objectives</h3> To define psychological MDHAQ as the mean score of Q11-13 and to validate it in RA patients <h3>Methods</h3> A previously validated Japanese version of MDHAQ was used in this study [2]. The validation of psychological MDHAQ included test-retest reliability (50 patients), content validity, and concurrent validity (348 patients). Hospital Anxiety and Depression Scale (HADS) was used as a comparator. <h3>Results</h3> Mean (SD) age and disease duration of the validation study population were 65.2 (12.1) years and 11.4 (10.5) years, respectively. The proportion of possible cases with anxiety (HADS-A ≥8), depression (HADS-D ≥8), and either anxiety, or depression (HADS-A ≥8 or HADS-D ≥8) was 21.5%, 25.4%, and 35.5%, respectively. The test-retest reliability of Q11, Q12, Q13, and psychological MDHAQ was 0.730, 0.757, 0.708 and 0.788 (Spearman9s rank correlation coefficient), respectively. The internal reliability of Q11, Q12, and Q13 was 0.930, 0.628, and 0.680 (Chronbach9s α), respectively. The correlation between Q11 and 12, Q11 and 13, and Q12 and 13 was 0.503, 0.463, and 0.891 (Spearman9s rank correlation coefficient), respectively. Psychological MDHAQ correlated with HADS while also showing a higher correlation with all patient-reported outcome measures (pain VAS, patient global VAS, HAQ, and RAPID3) than did HADS (Table 1). In screening for possible cases of anxiety, or depression, psychological MDHAQ ≥0.67 (total Q11-13 of ≥2) showed moderate agreement with HADS-A ≥8 or HADS-D ≥8 (kappa 0.441, p&lt;0.0001). <h3>Conclusions</h3> Psychological MDHAQ was found to be suitable for use in daily practice to assess psychological distress. <h3>References</h3> Pincus T, et al. Arthritis Rheum 1999;42:2220-30. Yokogawa N, et al. Mod Rheumatol 2014; 26:1-6. <h3>Disclosure of Interest</h3> None declared
Prevalence of Salmonella enterica serovar 4,[5],12:i:- in England and Wales, 2010
Authors: K L Hopkins, E de Pinna, J Wain
Journal: Eurosurveillance (2012)

Difficulties in accurately identifying serovar 4,[5],12:i:- as monophasic variants of Salmonella enterica serovar Typhimurium mean there is confusion in the reporting of serovars Typhimurium and 4,[5],12:i:-. To gain insight into the prevalence and diversity of these monophasic variants in England and Wales, screening for fljB, hin and the serovar 4,[5],12:i:- DT193-associated genomic island was conducted on 609 S. enterica isolates designated as definitive phage type (DT) 193, and 142 isolates serologically-defined as monophasic variants of serovar Typhimurium but belonging to phage types other than DT193. All latter 142 isolates were subtyped by multilocus variable-number tandem repeat analysis (MLVA). MLVA was also applied to 70 DT193 serologically-defined monophasic variant isolates. Results indicate that serovar 4,[5],12:i:- accounted for 108 of 209 (52%) of DT193 isolates with available serological data and 99 of 142 (70%) monophasic variant isolates belonging to other phage types. Of 609 DT193 isolates, 463 (76%) lacked fljB and hin. Moreover, genetically-related isolates of DTs 120, 191, 191a, 195, phage types U311 and U323, and reacts but does not conform (RDNC) and untypable (UT) strains were also lacking either hin and/or fljB. Of note, the serovar 4,[5],12:i:- DT193-associated genomic island was identified in not only 458 of 463 (99%) monophasic DT193 isolates, but also 25 of 139 (18%) biphasic DT193 isolates and 56 of 76 (74%) monophasic variants of other phage types. Accurate monitoring of the emergence of serovar 4,[5],12:i:- isolates is important to ascertain the public health impact of these strains; since 2012 the Health Protection Agency’s Salmonella Reference Unit has therefore begun determining full antigenic structures of all presumptive O:4 isolates in addition to routinely performing phage typing for identification of variants of serovar Typhimurium.
Use Of Nilotinib As a First Line Treatment In Adult Patients With Philadelphia Chromosome-Positive and Chronic Phase Myeloid Leukemia
Authors: Guray Saydam, Ibrahim C. Haznedaroglu, Leylagul Kaynar, Akif S. Yavuz, Ridvan Ali, Birol Guvenc, Olga M. Akay, Zafer Baslar, Ugur Ozbek, Mehmet Sonmez, Demet Aydin, Mustafa Pehlivan, Bulent Undar, Simten Dagdas, Orhan M. Ayyildiz, Diyar Z. Akkaynak, Ilkiz M. Dag, Osman Ilhan
Journal: Blood (2013)
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia
Authors: H Parker, M J J Rose-Zerilli, M Larrayoz, R Clifford, J Edelmann, S Blakemore, J Gibson, J Wang, V Ljungström, T K Wojdacz, T Chaplin, A Roghanian, Z Davis, A Parker, E Tausch, S Ntoufa, S Ramos, P Robbe, R Alsolami, A J Steele, G Packham, A E Rodríguez-Vicente, L Brown, F McNicholl, F Forconi, A Pettitt, P Hillmen, M Dyer, M S Cragg, C Chelala, C C Oakes, R Rosenquist, K Stamatopoulos, S Stilgenbauer, S Knight, A Schuh, D G Oscier, J C Strefford
Journal: Leukemia (2016)

Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and are disrupted at the genomic level in a spectrum of human tumours including haematological malignancies. Using high-resolution single nucleotide polymorphism (SNP) arrays, we identified recurrent deletions of the SETD2 locus in 3% (8/261) of chronic lymphocytic leukaemia (CLL) patients. Further validation in two independent cohorts showed that SETD2 deletions were associated with loss of TP53, genomic complexity and chromothripsis. With next-generation sequencing we detected mutations of SETD2 in an additional 3.8% of patients (23/602). In most cases, SETD2 deletions or mutations were often observed as a clonal event and always as a mono-allelic lesion, leading to reduced mRNA expression in SETD2-disrupted cases. Patients with SETD2 abnormalities and wild-type TP53 and ATM from five clinical trials employing chemotherapy or chemo-immunotherapy had reduced progression-free and overall survival compared with cases wild type for all three genes. Consistent with its postulated role as a tumour suppressor, our data highlight SETD2 aberration as a recurrent, early loss-of-function event in CLL pathobiology linked to aggressive disease.
The primal scene: a study of prevalence
Authors: A A Rosenfeld, C R Smith, A O Wenegrat, W Brewster, D K Haavik
Journal: American Journal of Psychiatry (1980)

Although primal scene experiences have been implicated as causal agents in innumerable psychopathologic states, no study of their actual prevalence exists. The authors conducted five separate studies, in which parents reported that 9%-41% of their children had seen parental intercourse. If the times children see parental intercourse without the parents knowing it and the times children hear parents making noises during intercourse were included, the prevalence would be much higher. In view of the frequent occurrence of primal scene experiences, factors other than the viewing itself must influence psychopathological outcomes when they occur.
Desmoid Tumor of the Popliteal Space Occurring During Pregnancy: Report of a Case with Bioassays
Authors: Ober, William B., Velardo, Joseph T., Greene, Robert T., Taylor, Richard J.
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Desmoid Tumor of the Popliteal Space Occurring During Pregnancy: Report of a Case with Bioassays Get access William B. Ober, M.D., William B. Ober, M.D. Departments of Pathology, Boston Lying-in Hospital and Harvard Medical School Search for other works by this author on: Oxford Academic PubMed Google Scholar Joseph T. Velardo, Ph.D., Joseph T. Velardo, Ph.D. Departments of Surgery, Peter Bent Brigham Hospital and Harvard Medical School Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert T. Greene, M.D., Robert T. Greene, M.D. Depart-ment of Orthopedic Surgery, Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard J. Taylor, M.D. Richard J. Taylor, M.D. Department of Pathology, Peter Bent Brigham Hospital, Boston, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 2, October 1955, Pages 569–577, https://doi.org/10.1093/jnci/16.2.569 Published: 01 October 1955 Article history Received: 19 May 1955 Published: 01 October 1955
Case review and quantity of outpatient care
Authors: B Blackwell, M Gutmann, L Gutmann
Journal: American Journal of Psychiatry (1988)

Case review for patients belonging to a health maintenance organization was implemented in a hospital-based, multidisciplinary, outpatient clinic after the influx of 28,000 Medicaid enrollees. One-year follow-up of 138 patients with prepaid mental health insurance and 283 patients with fee-for-service mental health insurance revealed an annual mean of 6.1 treatment sessions; 78% completed treatment within eight sessions. The modal treatment was a single visit. Prepaid and fee-for-service patients did not differ in amount of care, although significant differences were found for insurance subgroups. These preliminary results suggest that case review has little effect on quantity of care.
Survey of Hypnotics in General with Regard to Pulmonary-Tumor Induction in Mice
Authors: C. D. Larsen, Paul B. Rhoads, Jr., Lucille L. Weed
Journal: JNCI Journal of the National Cancer Institute (1946)

Survey of Hypnotics in General with Regard to Pulmonary-Tumor Induction in Mice Get access C. D. Larsen, C. D. Larsen research fellow National Cancer Institute, National Institute of Health, United States Public Health Service. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul B. Rhoads, Jr., Paul B. Rhoads, Jr. National Cancer Institute, National Institute of Health, United States Public Health Service. Search for other works by this author on: Oxford Academic PubMed Google Scholar Lucille L. Weed Lucille L. Weed National Cancer Institute, National Institute of Health, United States Public Health Service. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 1, August 1946, Pages 5–8, https://doi.org/10.1093/jnci/7.1.5 Published: 01 August 1946
PTH-189 Retrospective analysis of the cancer detection rates in patients referred via the two-week-wait (TWW) upper-gi endoscopy pathway in a single centre prior to the introduction of the national ‘be clear on cancer’ – heartburn awareness campaign
Authors: S Mcclements, M Roberts, H Ashcroft, A Robinson
Journal: Gut (2015)

The rootstock cultivars used in phylloxerated vineyards of the coastal districts of California are limited essentially to Rupestris St. George and Ganzin 1. Over the years, the suitability of Ganzin 1 for those vineyards has been questioned because it is less tolerant of phylloxera than is Rupestris St. George. Extensive field trials were conducted with a selected group of rootstocks from 1935 to 1941 in California vineyards. Data gathering was terminated in 1953, although several of those old trials remain. Comparative data on the growth and productivity of six scion varieties on five rootstocks were obtained from six of those trials in 1974 and 1975, when the trials were 35 to 40 years old. Scions on the two <i>vinifera</i> x <i>rupestris</i> rootstocks Ganzin 1 and Couderc 1202 have, in vegetative growth and fruit yield, performed equal to or better than those on Rupestris St. George. Root examinations in 1975 confirmed phylloxera on the roots of the <i>vinifera</i> x <i>rupestris</i> hybrids.
Prolactin response to tryptophan during mianserin treatment
Authors: P J Cowen
Journal: American Journal of Psychiatry (1988)

Unlike tricyclic antidepressants and monoamine oxidase inhibitors, mianserin did not increase prolactin response to the 5-hydroxytryptamine (5-HT) precursor tryptophan in nine patients with major depression. Antidepressant drugs apparently produce dissimilar effects on this aspect of brain 5-HT function in depressed patients.
SP0178 Genomic and Proteomic Quantification of the Heterogeneity of SSC: Implications for Pathogenesis and Treatment
Authors: M.L. Whitfield
Journal: Annals of the Rheumatic Diseases (2015)

Genome-wide stratification of patients into molecularly similar groups is rapidly becoming a key component of genetic-based precision medicine. Stratification using a patient9s gene expression fingerprint found in end target tissues such as skin is highly reproducible and can break down and quantify the heterogeneity in SSc. Although significant insights have been gained by analysis of individual datasets probing gene expression in end target tissues (skin, lung and PBMCs), integrative analysis of gene expression and proteomic data across multiple SSc cohorts and mulitiple SSc tissues provides additional power, inherent replication and the ability to identify deregulated processes common to each affected organ. We analyzed ten independent genome-wide gene expression datasets from multiple SSc tissues that allow for a systematic reanalysis of the SSc transcriptome and, in particular, allow us to identify the conserved molecular drivers of the intrinsic gene expression subsets (inflammatory, fibroproliferative, limited and normal-like) that are found in multiple end-target tissues including skin, esophagus and lung. These data show the intrinsic gene expression subsets are conserved across different tissues in SSc and may represent fundamental mechanisms underlying the pathogenesis of the disease. We find that different pathways are deregulated in each of these subsets, suggesting each subset will respond differently to therapy. We also performed analysis of the autoantibody targets in SSc using immunopreciptiation of protein lysates with patient autoantibodies followed by mass spectrometric analysis of the recovered antigens, which suggests a model in which a combination of chronic and acute cellular stresses results in aberrant cell death, leading to autoantibody generation directed against intracellular macromolecular structures. Analysis of skin biopsies from SSc patients in multiple, independent clinical trials provides support for our hypothesis that patient gene expression subset will be a major determinant of those individuals most likely to respond to a particular therapeutic intervention. <h3>Disclosure of Interest</h3> None declared
Elevation of cerebrospinal fluid soluble CD27 levels in patients with meningeal localization of lymphoid malignancies [published erratum appears in Blood 1996 Oct 1;88(7):2818]
Authors: MJ Kersten, LM Evers, PL Dellemijn, H van den Berg, P Portegies, RQ Hintzen, RA van Lier, AE von dem Borne, RH van Oers
Journal: Blood (1996)