tbuckley/cabot-search huggingface dataset:
Assessing BCG vaccination coverage and incidence of paediatric tuberculosis following two major changes in BCG vaccination policy in France
Authors: J P Guthmann, D Antoine, L Fonteneau, D Che, D Lévy-Bruhl
Journal: Eurosurveillance (2011)

We report data on BCG vaccination coverage and paediatric tuberculosis (TB) incidence collected after the disappearance of the multipuncture device for BCG vaccination in January 2006 and the shift from universal to targeted vaccination in July 2007 in France.Vaccination coverage estimates in children for whom BCG is recommended allow assessing whether the recommendations are followed by doctors and/or accepted by the target population. In January and February 2006, BCG sales to the private sector in Îlede-France region were 74.2% and 41.3% of the ones for the same months the previous year. Total sales in 2006 amounted to 57.3% of those in 2005. Coverage decreased immediately after withdrawal of the multipuncture device, and remained generally insufficient in high risk children in the following years. However,the impact on paediatric TB incidence in 2008 seems very limited, although the duration of follow-up is still short. Training of doctors in intra-dermal vaccination and communication on the new vaccination policy should be strengthened
COPPER DEPOSITION AND THE KIDNEYS
Authors: F A KINGERY
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease
Authors: Fu L Luan, Silas P Norman
Journal: New England Journal of Medicine (2010)

BACKGROUND-In observational studies, the relationship between blood pressure and endstage renal disease (ESRD) is direct and progressive.The burden of hypertension-related chronic kidney disease and ESRD is especially high among black patients.Yet few trials have tested whether intensive blood-pressure control retards the progression of chronic kidney disease among black patients.METHODS-We randomly assigned 1094 black patients with hypertensive chronic kidney disease to receive either intensive or standard blood-pressure control.After completing the trial phase, patients were invited to enroll in a cohort phase in which the blood-pressure target was less than 130/80 mm Hg.The primary clinical outcome in the cohort phase was the progression of chronic kidney disease, which was defined as a doubling of the serum creatinine level, a diagnosis of ESRD, or death.Follow-up ranged from 8.8 to 12.2 years.RESULTS-During the trial phase, the mean blood pressure was 130/78 mm Hg in the intensivecontrol group and 141/86 mm Hg in the standard-control group.During the cohort phase, corresponding mean blood pressures were 131/78 mm Hg and 134/78 mm Hg.In both phases, there was no significant between-group difference in the risk of the primary outcome (hazard ratio in the intensive-control group, 0.91; P = 0.27).However, the effects differed according to the baseline level of proteinuria (P = 0.02 for interaction), with a potential benefit in patients with a protein-to-creatinine ratio of more than 0.22 (hazard ratio, 0.73; P = 0.01).CONCLUSIONS-In overall analyses, intensive blood-pressure control had no effect on kidney disease progression.However, there may be differential effects of intensive blood-pressure control in patients with and those without baseline proteinuria.
A conjoint psychiatry-internal medicine program: development of a teaching and clinical model
Authors: J P Shemo, J C Ballenger, J J Yazel, W W Spradlin
Journal: American Journal of Psychiatry (1982)

At a time when psychiatry's repertoire of successful treatment strategies is burgeoning and the public is seeking primary medical care with greater emphasis on humanistic issues, psychiatry has been paradoxically losing status and trainees, partly because it has failed to make its expertise integratable by nonpsychiatric physicians. In response to the educational and patient care deficiencies that result, two universities developed a teaching and clinical program that leads to partial integration of their departments of psychiatry and internal medicine. This collaborative approach includes a conjoint internal medicine-behavioral medicine inpatient unit and a residency program leading to Board eligibility in both specialties.
Associations of Pregnancy Outcomes and PM <sub>2.5</sub> in a National Canadian Study
Authors: David M. Stieb, Li Chen, Bernardo S. Beckerman, Michael Jerrett, Daniel L. Crouse, D. Walter Rasugu Omariba, Paul A. Peters, Aaron van Donkelaar, Randall V. Martin, Richard T. Burnett, Nicolas L. Gilbert, Michael Tjepkema, Shiliang Liu, Rose M. Dugandzic
Journal: Environmental Health Perspectives (2015)

BackgroundNumerous studies have examined associations between air pollution and pregnancy outcomes, but most have been restricted to urban populations living near monitors.ObjectivesWe examined the association between pregnancy outcomes and fine particulate matter in a large national study including urban and rural areas.MethodsAnalyses were based on approximately 3 million singleton live births in Canada between 1999 and 2008. Exposures to PM2.5 (particles of median aerodynamic diameter ≤ 2.5 μm) were assigned by mapping the mother's postal code to a monthly surface based on a national land use regression model that incorporated observations from fixed-site monitoring stations and satellite-derived estimates of PM2.5. Generalized estimating equations were used to examine the association between PM2.5 and preterm birth (gestational age < 37 weeks), term low birth weight (< 2,500 g), small for gestational age (SGA; < 10th percentile of birth weight for gestational age), and term birth weight, adjusting for individual covariates and neighborhood socioeconomic status (SES).ResultsIn fully adjusted models, a 10-μg/m3 increase in PM2.5 over the entire pregnancy was associated with SGA (odds ratio = 1.04; 95% CI 1.01, 1.07) and reduced term birth weight (–20.5 g; 95% CI –24.7, –16.4). Associations varied across subgroups based on maternal place of birth and period (1999–2003 vs. 2004–2008).ConclusionsThis study, based on approximately 3 million births across Canada and employing PM2.5 estimates from a national spatiotemporal model, provides further evidence linking PM2.5 and pregnancy outcomes.CitationStieb DM, Chen L, Beckerman BS, Jerrett M, Crouse DL, Omariba DW, Peters PA, van Donkelaar A, Martin RV, Burnett RT, Gilbert NL, Tjepkema M, Liu S, Dugandzic RM. 2016. Associations of pregnancy outcomes and PM2.5 in a National Canadian Study. Environ Health Perspect 124:243–249; http://dx.doi.org/10.1289/ehp.1408995
SP0121 Me and My GP – Patient's Perspective
Authors: C.R. Ziegler
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Most patients with rheumatoid arthritis are seen and treated in both primary and secondary care. Rheumatoid arthritis is mainly treated by the rheumatologist. Comorbidities to rheumatoid arthritis as for example osteoporosis and cardiovasculardiseases are in Denmark mainly diagnosed in secondary care, while monitoring, prescription etc. will be taken care of in primary care. Sometimes the patient can find it difficult to act in this field: When is the rheumatologist to be consulted and when the GP? The patient need to make decisions, be the coordinator and find out whom to contact when. It might seem easy, but sometimes patients are uncertain. Furthermore the patient often discover problems related to communication between primary and secondary care. The lack of information and exchange of results make most patients worry and can sometimes make the patient too responsible for their own care. <h3>Objectives</h3> –To clarify the problems in a still more specialized health care system, in which patients with complex diseases have to interact – for the rest of their lives –To describe the dialogue between the three partners: patient, primary and secondary care –To exemplify practical solutions for improved dialogue – for the benefit of everybody involved <h3>Results</h3> A small survey was conducted among a network of Danes with rheumatoid arthritis. The patient9s suggestions on how to act and how to improve the dialogue will be concluded during the presentation. <h3>Disclosure of Interest</h3> None declared
Somatostatin Receptor Scintigraphy Patterns in Patients With Sarcoidosis
Authors: Lieke S. Kamphuis, Dik J. Kwekkeboom, Tom O. Missotten, G. Seerp Baarsma, Virgil A. Dalm, Willem A. Dik, W. Marieke Timmermans, Paul L. van Daele, P. Martin van Hagen, Jan A. van Laar
Journal: Clinical Nuclear Medicine (2015)

Sarcoidosis is a multisystem granulomatous disorder, most frequently involving the lungs, skin, or eyes. Somatostatin receptor scintigraphy (SRS) can visualize sarcoid granulomas through binding of a radionuclide-coupled somatostatin analog to somatostatin receptors that are expressed in sarcoidosis. Uptake and patterns on SRS were studied and correlated to clinical and conventional findings.Data of 218 SRSs undertaken for the analysis of potential sarcoidosis were studied. These scintigraphies were retrospectively studied on intensity uptake degrees and localization of sarcoidosis-associated lesions, and compared with conventional radiological techniques (chest x-ray and CT).In all but 1 of the 175 evaluable patients, SRS demonstrated uptake. In patients with thoracic sarcoidosis-associated lesions, SRS improved the yield of visualization of chest x-ray in 20 (36%) and CT in 7 (32%) of histologically unproven patients, and in 31 (30%) and 8 (14%) of the histologically proven patients, respectively. Mediastinal lesions together with either eye, salivary glands, clavicular, or hilar localizations were most frequent demonstrated on SRS and constituted characteristic patterns. Exclusive extrapulmonary disease was found in 6% of the patients.Somatostatin receptor scintigraphy enhances the yield of investigations in sarcoidosis patients and therefore provides a useful and sensitive imaging technique to monitor organ involvement and therapeutic efficacy in patients with sarcoidosis.
High-dose chemotherapy for breast cancer.
Authors: P P Carbone
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.2.167 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3806164 High-dose chemotherapy for breast cancer. P P CarbonexP P CarboneSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.2.167 PDF "High-dose chemotherapy for breast cancer.." Journal of Clinical Oncology, 5(2), pp. 167–168© 1987 by American Society of Clinical Oncology
Counsellors do not have to be genetic nurse specialists
Authors: P. Kent
Journal: BMJ (1996)

EDITOR,—It is interesting that authors of papers on screening for cystic fibrosis and other genetic disorders take it for granted that carriers should be counselled by genetic nurse specialists.1 The implication is that only a genetic nurse specialist will, or even could, have the required understanding and knowledge. It also seems to be unquestioningly accepted that all genetic nurse specialists are trained counsellors. I wonder if I am alone in questioning this received wisdom.

About 280 children …
AB0346 Correlation of Disease Duration, Disease Activity and Pain to Fatigue – a Systematic Review
Authors: S. Groth Madsen, B. Danneskiold-Samsøe, A. Stockmarr, E.M. Bartels
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) patients suffer from disabling fatigue, and both The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) have identified fatigue as an outcome of great importance to patients. Patients describe their fatigue to be physical and/or mental fatigue, which makes them unable to complete their daily tasks. Since the aetiology of fatigue is unknown, Treatment of fatigue is a great challenge. <h3>Objectives</h3> Trying to find some of the causes behind fatigue, our aim was to assess which of the variables: disease activity, disease duration, and pain, could be associated to fatigue. <h3>Methods</h3> A systematic literature search in the bibliographic databases Medline and EMBASE followed by selection of studies according to set criteria, data extraction, and statistical analyses of the relationships in RA between fatigue and the covariates: disease duration, erythrocyte sedimentation rate (ESR), C-reactive Protein (CRP), DAS28, swollen/tender joints, and pain. Linear regression analyses of fatigue regressed on each of the six covariates, and a multiple regression analysis where fatigue was regressed on the six covariates through a forward selection procedure was carried out with construction of correlation measures between fatigue and the covariates. <h3>Results</h3> 121 studies were included in the analyses, including &gt;100.000 RA patients. A high level of fatigue was seen even in well-treated patients (according to DAS28), demonstrating fatigue as a major problem in RA. Fatigue was found positively correlated to Pain, CRP, DAS28, and ESR, but not to the Swollen/Tender joint-ratio, or Disease duration. When the covariates were considered simultaneously with pain, the additional information contained in the other covariates were negligible, pain was the overall domineering factor in experience of fatigue. <h3>Conclusions</h3> Fatigue has a substantial influence on the lives of RA patients, independent of disease duration. Pain is the domineering factor in the experience and degree of fatigue. Disease activity is positively correlated to fatigue, but does not contribute substantially when pain is considered. Optimal pain relief is therefore an important part of the treatment if one wishes to improve fatigue in RA. The protocol for this study was registered in Prospero with registration number: CRD42013004178. <h3>Acknowledgements</h3> This study was supported by the OAK Foundation <h3>Disclosure of Interest</h3> None declared
The Sedimentation of the Rous Sarcoma Virus
Authors: H. Kahler, W. R. Bryan, B. J. Lloyd, Jr., J. B. Moloney
Journal: JNCI Journal of the National Cancer Institute (1954)

The Sedimentation of the Rous Sarcoma Virus Get access H. Kahler, H. Kahler National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. R. Bryan, W. R. Bryan National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar B. J. Lloyd, Jr., B. J. Lloyd, Jr. National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. B. Moloney J. B. Moloney National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 337–339, https://doi.org/10.1093/jnci/15.2.337 Published: 01 October 1954 Article history Received: 14 June 1954 Published: 01 October 1954
Reduced Risk for Pancreatitis after Endoscopic Microtransducer Manometry of the Sphincter of Oddi: A Randomized Comparison with the Perfusion Manometry Technique
Authors: T.  Wehrmann, N.  Stergiou, T.  Schmitt, C.  F.  Dietrich, H.  Seifert
Journal: Endoscopy (2003)

Endoscopic microtransducer manometry of the sphincter of Oddi has been shown to be a reliable alternative to perfusion manometry for evaluating sphincter of Oddi motor function. It avoids volume loading of the biliopancreatic system, and may therefore be associated with a lower risk of inducing postmanometry pancreatitis.[nl]During a 2-year period, microtransducer manometry of the sphincter of Oddi was carried out in 215 patients (median age 42 years; 155 women; biliary study in 152 cases, additional pancreatic evaluation in 63 cases). Sphincter of Oddi manometry was conducted as the sole procedure in all patients. The frequency of pancreatitis was assessed prospectively and graded according to established guidelines. A total of 130 consecutive patients (median age 37 years, 92 women; 30 with biliary type II, 58 with type III, 34 with pancreatic type I, and eight with type II) were then randomly assigned to undergo microtransducer or perfusion manometry of the sphincter of Oddi in a standardized fashion.During the initial 2-year period, nine cases of pancreatitis (a pancreatitis frequency of 4.2 %) were observed after microtransducer manometry, and most were of mild degree (six mild, two moderate, and one severe). No deaths occurred, and no surgical procedures were required. In the randomized part of the study, the demographic and clinical characteristics of the patients in both groups, as well as the technical aspects of the procedures performed, were well matched. The frequency of pancreatitis after microtransducer manometry was 3.1 %, compared with 13.8 % after perfusion manometry ( P < 0.05). Pancreatitis occurred in two patients after microtransducer manometry, and was mild in both cases. After perfusion manometry, mild pancreatitis occurred in six patients and moderate pancreatitis in three.Endoscopic microtransducer manometry of the sphincter of Oddi is associated with a lower risk for postmanometry pancreatitis than standard perfusion manometry.
ECT-induced delirium and further ECT: a case report
Authors: W F Daniel, R D Weiner, H F Crovitz, G B Strong, M M Christenbury
Journal: American Journal of Psychiatry (1983)

The authors report the occurrence of a severe confusional state (DSM-III delirium) in a patient who received bilateral sinusoidal ECT. Unilateral brief-pulse ECT was then used to successfully treat the patient's depression without the redevelopment of delirium.
Leukemoid Reaction to Parenteral Iron-Dextran Complex
Authors: Larry D. Samuels
Journal: JAMA (1962)

AN IBON-DEXTBAN COMPLEX (Imferon) used for parenteral treatment of iron deficiency anemia was recently rereleased for general use ' after a 2-year withdrawal from the market, which was occasioned by some reports of sarcoma production in experimental animals. Originally, the drug received considerable praise for its efficacy. Although present opinions vary, this iron-dextran complex was adjudged of sufficient merit to prompt its return to use in the U.S. However, continued caution in its use is advised and it is timely to consider its side effects. I present here a case report prepared at about the time of its removal from the American market and now especially relevant. In reporting a case of toxic reaction to intramuscular iron-dextran, manifest by arthralgia, Shafer and Marlow review the literature reported on toxic manifestations and conclude that these are infrequent. Skin rashes, local cellulitis, anaphylactoid reactions, and febrile reactions have been noted. In 1961, Ben-Ishay,
Malignant Lymphomas of Follicular Center Cell Origin in Man. I. Immunologic Studies23
Authors: J. H. Leech, A. D. Glick, J. A. Waldron, J. M. Flexner, R. G. Horn, R. D. Collins
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article Malignant Lymphomas of Follicular Center Cell Origin in Man. I. Immunologic Studies Get access J. H. Leech, B.A., J. H. Leech, B.A. Search for other works by this author on: Oxford Academic PubMed Google Scholar A. D. Glick, M.D., A. D. Glick, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. A. Waldron, M.D., Ph.D., J. A. Waldron, M.D., Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. M. Flexner, M.D., J. M. Flexner, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. G. Horn, M.D., R. G. Horn, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. D. Collins, M.D. R. D. Collins, M.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 54, Issue 1, January 1975, Pages 11–21, https://doi.org/10.1093/jnci/54.1.11 Published: 01 January 1975 Article history Received: 24 June 1974 Accepted: 16 August 1974 Published: 01 January 1975
Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles
Authors: Chin-Yu Lin, Federico Perche, Masaru Ikegami, Satoshi Uchida, Kazunori Kataoka, Keiji Itaka
Journal: Journal of Controlled Release (2016)