tbuckley/cabot-search huggingface dataset:
NT-14 * EARLY EXPERIENCE WITH TRANS-SULCAL PARAFASCICULAR EXOSCOPIC RESECTION OF SUPRATENTORIAL BRAIN TUMORS
Authors: J. K. Eliyas, J. Bailes
Journal: Neuro-Oncology (2014)

BACKGROUND: Resection of subcortical lesions is limited by concern for procedure-related injury to critical structures. Such a concern may impede the ability to resect completely and such an injury may affect post-operative recovery significantly. The parafascicular approach involves planned navigation of working channel parallel to critical fascicles when accessing subcortical lesions. This reduces shear injury to major white matter tracts and is achieved by inserting a tapered dilating access device (Neuroport) through a sulcus. Use of an exoscope increases illumination and clarity in optics that go hand in hand with the tenants of this approach. Here we present our early experience with this technique. METHODS: We reviewed our first 10 supratentorial brain tumors that were resected using the 6-pillar approach of parafascicular minimally invasive exoscopic resection. The eligible patients underwent further data analysis focusing on pathology and outcome from this approach. RESULTS: Ten patients with a mean age of 63 years underwent resection of both primary and metastatic lesions. There were no adverse events related to port placement or approach. Eight had primary neoplasm of which 6 were WHO grade IV. Two other lesions were metastatic in nature. Two patients died but both succumbed to their neoplasm and not surgery or its complications. One developed supplementary motor area syndrome following resection of rapidly growing left frontal Glioblastoma. Tumor resection was gross total in all cases. Hospital stay averaged 2.5 days. CONCLUSIONS: Trans-sulcal parafascicular navigated exoscopic resection is rapidly becoming an established way of managing subcortical brain tumors and other lesions, especially intra-cerebral hematomas. Our early results are better than conventional open surgical resection, with inaccessible lesions becoming accessible and shorter hospital stays. With this minimally invasive (minimally disruptive) approach, we see decrease in injury to both vital cortex and significant large white matter tracts thus preserving maximum neurological function.
TCT-169 Exit Angiography and Intraoperative Stenting after Surgical Repair of Complex Congenital Heart Disease in a Hybrid Room: Impact on Management Strategies and Outcomes
Authors: Carlos Pedra, Rodrigo Costa, Marcelo Ribeiro, Paulo Chaccur, Glaucio Furlanetto, Magaly Arrais, Ana L. Guerra, Virginia Santana, Simone Pedra, Valmir Fontes
Journal: Journal of the American College of Cardiology (2014)
EFECTIVIDAD DE LAS PRÓTESIS EVO-C EN EL TRATAMIENTO DE LA OBSTRUCCIÓN COLÓNICA AGUDA NEOPLÁSICA: ¿SE RELACIONA CON EL DIÁMETRO DE APERTURA INMEDIATA?
Authors: B López Viedma, J Rodríguez Sánchez, M Alonso Lablanca, R Lorente Poyatos, F Domper Bardají, J Olmedo Camacho
Journal: Endoscopy (2012)

Antecedentes: El uso de prótesis metálicas autoexpansibles (PMAE) como tratamiento de la obstrucción colónica aguda neoplásica (OCAN) es una práctica bien establecida, aunque existen pocos estudios que relacionen el éxito clínico y el grado de expansión inmediato postinserción. OBJETIVO: Evaluar si el diámetro de expansión inmediata postinserción de las prótesis EVO-C (Evolution TM EVO-C, Cook Medical, USA) determina el éxito clínico inmediato. Material y método: Análisis retrospectivo observacional (Nov 2009-Nov 2011) sobre cohorte de pacientes con OCAN tratados con prótesis EVO-C. Resultados: 22 pacientes (12 mujeres, edad media 70 años). Puente cirugía: 10, paliativo: 12. Localización: recto: 5, sigma: 14, descendente: 3. Éxito técnico 21/22 (95,5%) (un caso no progresión guía tutora).Éxito clínico inmediato: 85,7%, éxito clínico final seguimiento: 76,2%.Complicaciones: perforación inmediata/tardía 1/1 (9,5%), migración: 2 (9,5%), obstrucción tardía por invasión tumoral de la luz de la prótesis: 1 (4,7%). Media de la permeabilidad: puente cirugía/paliativo: 29/210días. Media apertura en punto de menor expansión inmediata/48 horas: 7,8 (3,7–23mm)/15,9 [10–23mm (incremento 100%)]. Se comparó diámetro de expansión inmediata 25% del total con el éxito clínico inmediato sin evidenciar diferencias, y con el éxito clínico final de seguimiento encontrando diferencias significativas (p=0,028; OR: 12, IC95%:1,01–141,3) Conclusiones: Las prótesis EVO-C muestran una elevada capacidad de expansión postinserción. En nuestra experiencia, su alta efectividad en la resolución de la obstrucción colónica aguda neoplásica se alcanza siempre que el diámetro de expansión inmediata postinserción sea, al menos, del 25% del diámetro máximo.
P788 RANDOMIZED TRIAL OF INTEGRATED CARE TO PROMOTE DIRECT ACTING ANTIVIRAL TREATMENT AMONG HIGH RISK HEPATITIS C PATIENTS WITH PSYCHIATRIC AND SUBSTANCE USE DISORDERS
Authors: S.B. Ho, E.J. Groessl, L. Liu, C.M. Sanchez, M.M. Wasil, S.K. Robinson
Journal: Journal of Hepatology (2014)
895 EVALUATION OF PROFILE RELAPSED AND PERSISTENT SUSTAINED VIRAL RESPONSE IN PATIENTS WITH HEPATITIS C WHICH RECEIVED DIRECT-ACTING ANTIVIRAL DRUGS
Authors: B. Ruiz-Antoran, J.L. Calleja, J. de la Revilla, J.L. Martinez, F. Pons, E. Llop, M. Trapero, K. Torres, J. Selmo, M. Gomez, L. Abreu
Journal: Journal of Hepatology (2013)
Asthma Disease Management
Authors: Charles J. Homer
Journal: New England Journal of Medicine (1997)

Asthma presents a difficult problem — despite effective therapy, many patients have frequent symptoms and hospitalizations. In the United States, the prevalence of asthma, associated death rates, and outpatient visits for asthma have risen by almost 50 percent over the past decade.1,2 Hospitalization rates are 3.5 to 5 times higher for blacks than whites, and mortality rates are 5 to 10 times higher.3 Many patients with asthma, particularly those who are poor, do not receive optimal care. Differences in the quality of care may contribute to the racial and socioeconomic differences in the outcomes of asthma.46 Clinical-practice guidelines . . .
Chromosomal Instability Affects the Tumorigenicity of Glioblastoma Tumor-Initiating Cells
Authors: Kristina M. Godek, Monica Venere, Quilian Wu, Kevin D. Mills, William F. Hickey, Jeremy N. Rich, Duane A. Compton
Journal: Cancer Discovery (2016)

Abstract Tumors are dynamic organs that evolve during disease progression with genetic, epigenetic, and environmental differences among tumor cells serving as the foundation for selection and evolution in tumors. Tumor-initiating cells (TIC) that are responsible for tumorigenesis are a source of functional cellular heterogeneity, whereas chromosomal instability (CIN) is a source of karyotypic genetic diversity. However, the extent that CIN contributes to TIC genetic diversity and its relationship to TIC function remains unclear. Here, we demonstrate that glioblastoma TICs display CIN with lagging chromosomes at anaphase and extensive nonclonal chromosome copy-number variations. Elevating the basal chromosome missegregation rate in TICs decreases both proliferation and the stem-like phenotype of TICs in vitro. Consequently, tumor formation is abolished in an orthotopic mouse model. These results demonstrate that TICs generate genetic heterogeneity within tumors, but that TIC function is impaired if the rate of genetic change is elevated above a tolerable threshold. Significance: Genetic heterogeneity among TICs may produce advantageous karyotypes that lead to therapy resistance and relapse; however, we found that TICs have an upper tolerable limit for CIN. Thus, increasing the chromosome missegregation rate offers a new therapeutic strategy to eliminate TICs from tumors. Cancer Discov; 6(5); 532–45. ©2016 AACR. This article is highlighted in the In This Issue feature, p. 461
Sex Differences in the Effect of Diabetes Mellitus on Lipoprotein Triglyceride and Cholesterol Concentrations
Authors: Carolyn E. Walden, Robert H. Knopp, Patricia W. Wahl, Kirk W. Beach, Eugene Strandness
Journal: New England Journal of Medicine (1984)

We studied sex differences in the serum lipid abnormalities associated with diabetes mellitus in 111 patients with insulin-dependent diabetes and 270 patients with non-insulin-dependent diabetes, who were compared with 586 nondiabetic controls. Relative to control levels, the increases in triglycerides were 17 to 34 mg per deciliter greater in diabetic women than in diabetic men. The median low-density-lipoprotein cholesterol concentration in non-insulin-dependent diabetics was 1 to 4 mg per deciliter lower than the control level in women and 16 to 22 mg per deciliter lower in men, and was 30 mg per deciliter higher than control in insulin-dependent diabetic women and similar to control in insulin-dependent diabetic men. The decrease in median high-density-lipoprotein cholesterol in non-insulin-dependent diabetics was 2 to 7 mg per deciliter greater in women than in men, and the increase in high-density-lipoprotein cholesterol in insulin-dependent diabetics was 3 mg per deciliter less in women than in men. We conclude that diabetes has a greater adverse effect on triglyceride and lipoprotein cholesterol concentrations in diabetic women than in diabetic men, and that this may explain the greater increase in risk of arteriosclerosis in diabetic women.
In vitro evaluation of the radial and axial force of self-expanding esophageal stents
Authors: Meike Hirdes, Frank Vleggaar, Matthieu de Beule, Peter Siersema
Journal: Endoscopy (2013)

Technological innovation in esophageal stent design has progressed over the past decades, but the association between the mechanical properties of stent design and clinical outcome is still poorly understood. In this study the radial force and axial force of currently available stent designs were evaluated using an in vitro testing model.A total of 10 partially and fully covered self-expanding metal stents (SEMSs), a self-expanding plastic stent (SEPS), and an uncovered biodegradable stent were evaluated. Radial force and axial force were measured using a radial force measurement machine (RX500) and a force gauge in an oven at 37°C.A wide range of radial force measurements were observed between the different stent designs, ranging from 4 to 83 N at 15 mm expansion. All braided nitinol stents displayed comparable mechanical characteristics with a relatively low radial force (<150 N) that gradually decreased to 0 N during expansion, whereas plastic and metal stents that were constructed in a nonbraided manner displayed an initially high radial force (>300 N) followed by a steep decline to 0 N during expansion. Conversely, peak axial force was relatively high for braided nitinol SEMSs (>1.5 N), whereas nonbraided SEMSs showed a much lower peak axial force (<1.5 N). Based on radial and axial force data, five groups of stents with comparable mechanical properties could be distinguished.All currently available stents have a characteristic radial and axial force pattern, which may aid in the understanding of the occurrence of specific symptoms and complications after stent placement. Nonetheless, the overall clinical behavior of a stent is probably more complex and cannot be explained by these factors alone.
Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men
Authors: Paul M. Ridker, Mary Cushman, Meir J. Stampfer, Russell P. Tracy, Charles H. Hennekens
Journal: New England Journal of Medicine (1997)

Inflammation may be important in the pathogenesis of atherothrombosis. We studied whether inflammation increases the risk of a first thrombotic event and whether treatment with aspirin decreases the risk.
Abstract 5408: CD73 as a target in cancer immunotherapy
Authors: Mark J. Smyth, Paul Beavis, Phil K. Darcy, Sherene Loi, John Stagg
Journal: Cancer Research (2012)

Abstract It is increasingly being recognised that the tumor microenvironment modulates the effector functions of tumor-infiltrating lymphocytes and consequently suppresses anti-tumor immunity. One immunosuppressive component of the tumor microenvironment is elevated levels of adenosine. The conversion of ATP into adenosine occurs in a stepwise manner essentially through the enzymatic activity of CD39 (NTPDase I) (ATP&amp;gt;AMP) and CD73 (ecto-5′-nucleotidase- AMP&amp;gt;adenosine). CD73 is a glycosylphosphatidyl-inositol (GPI)-linked cell surface enzyme constitutively expressed on endothelial cells, foxp3+ Tregs and subsets of leukocytes, and is considered as the rate-limiting enzyme in the production of extracellular adenosine. We have recently demonstrated that one of the mechanisms contributing to the immunosuppressive accumulation of extracellular adenosine in tumors is the expression of CD73 by tumor cells, but CD73 expression on foxp3+ Tregs is also important for their suppression of anti-tumor immunity. We now report on the role of host-derived CD73 in de novo tumor development in mice. Combinations of anti-CD73 with agonist and T cell checkpoint blockade antibodies demonstrate significant beneficial effects in experimental and de novo models of tumorigenesis. In humans using large cohorts we have shown that CD73 is highest in triple negative breast cancer (TNBC) and expression correlates with an invasion marker and the lack of ER signalling. CD73 expression is also associated with a worse prognosis in TNBC irrespective of treatment and predicts response to anthracycline therapy. The development of CD73 as a target for cancer immunotherapy will be further discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5408. doi:1538-7445.AM2012-5408
AB0273 Personal Factors Important to People with Rheumatoid Arthritis and their Coverage by Patient-Reported Outcome Measures: Table 1.
Authors: M. Dür, M. Coenen, V. Fialka-Moser, A. Kautzky-Willer, I. Kjeken, M. Mattsson, C. Boström, J. Smolen, T. Stamm
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> There is an increasing call to use patient reported outcome measures (PROMs) in health outcome research, because the perspective of patients is an essential part concerning the end results of health care. The coverage of patients9 perspective by PROMs relevant in rheumatoid arthritis (RA) has been examined regarding all domains of the International Classification of Functioning, Disability and Health (ICF) except <i>personal factors</i> (<i>PFs)</i>. Since the ICF did not classify PF, some researchers attempted to provide a classification of the <i>PFs</i>. <h3>Objectives</h3> We aimed to identify themes meaningful to people with RA, to determine which of these were attributed to <i>PFs</i> previously and to explore their coverage by PROMs. <h3>Methods</h3> We explored life stories to identify themes meaningful to people with RA and determined whether they have been previously attributed to <i>PFs</i> in the existing literature. Additionally we conducted a systematic literature search to identify PROMs relevant in RA. Finally, we explored whether the identified PROMs cover those themes which were attributed <i>PFs</i> previously. <h3>Results</h3> Twenty-two themes were found to be meaningful to 15 people with RA, of which 13 were attributed to <i>PFs</i> previously. Five themes were linked to activity and participation or environmental factors and four were not covered by the ICF. The systematic literature search resulted in the identification of 33 PROMs. Of these, the London Coping with Rheumatoid Arthritis Questionnaire and the Rheumatoid Arthritis Self-Efficacy Questionnaire covered most <i>PFs</i>. Examples of the coverage of themes attributed to <i>PF</i>s by PROMs are depicted at the Table 1. <h3>Conclusions</h3> The findings provide information about which <i>PFs</i> are meaningful to people with RA and could thus be targeted in non-pharmaceutical interventions. To our knowledge this was the first study exploring the coverage of <i>PFs</i> by PROMs relevant in RA. The exploration of the PROMs can support clinicians and other health professionals with the choice of which PROMs to use when developing or evaluating the effect of their interventions. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3154
Bacillus Calmette-Guerin Injections for Melanoma Immunotherapy
Authors: Steven M. Sogge, Joseph S. Fotos, Mark Tulchinsky
Journal: Clinical Nuclear Medicine (2015)

An 82-year-old woman presented for routine follow-up PET/CT after undergoing local melanoma resection in the left lower leg, isolated limb infusion chemotherapy, and immunomodulation therapy with Bacillus Calmette-Guérin (BCG) vaccine. Symmetric, bilateral, moderately intense FDG avid axillary and inguinal cutaneous nodules were observed that were new from the prior PET-CT. The patient had developed skin lesions at the BCG injection sites several months before the study. The case raises awareness to PET/CT appearance of local inflammatory response to BCG injection, which could be mistaken by an unaware reader for recurrent melanoma.
AORTOPATHY IN HYPERTROPHIC CARDIOMYOPATHY; THE ASSOCIATION WITH SINUS OF VALSALVA VERSUS MID ASCENDING AORTA: AN EPIDEMIOLOGICAL STUDY
Authors: Mirza Nubair Ahmad, Mirza Mujadil Ahmad, Sharmeen Fatima Hussaini, Bijoy K. Khandheria, Renuka Jain, A. Jamil Tajik, Khawaja Afzal Ammar
Journal: Journal of the American College of Cardiology (2016)
Abstract 3657: Upregulation of PD-1 and Tim-3 expression on tumor antigen-specific CD4+ T cells is associated with reversible T cell dysfunction in patients with advanced melanoma
Authors: Julien Fourcade, Zhaojun Sun, Philippe Guillaume, Immanuel F. Luescher, Cindy Sander, John M. Kirkwood, Vijay Kuchroo, Hassane M. Zarour
Journal: Cancer Research (2011)

Abstract The paradoxical coexistence of spontaneous tumor antigen-specific immune T cell responses with progressive disease in cancer patients furthers the need to dissect the molecular pathways involved in tumor-induced T cell dysfunction and exhaustion. We have previously observed in patients with advanced melanoma that the cancer-germline antigen NY-ESO-1 stimulates spontaneous NY-ESO-1-specific CD8+ T cells that upregulate PD-1 expression and that a fraction of PD-1+ NY-ESO-1-specific CD8+ T cells upregulates Tim-3 expression. We have found that Tim-3+PD-1+ NY-ESO-1-specific CD8+ T cells represent highly dysfunctional T cells in terms of cytokine production and proliferation. Importantly, Tim-3/Tim-3L blockade together with PD-1/PD-L1 blockade enhanced cytokine production and proliferation of NY-ESO-1-specific CD8+ T cells upon prolonged antigen stimulation. Whether the upregulation of PD-1 and Tim-3 is associated with tumor antigen-specific CD4+ T cell dysfunction/exhaustion in patients with advanced melanoma remains unknown. Here, our findings show that in contrast to EBV-specific, CMV-specific and total CD4+ T cells, PD-1 and Tim-3 expression is upregulated by NY-ESO-1-specific CD4+ T cells isolated from peripheral blood lymphocytes of patients with advanced melanoma. Interestingly, PD-1/PD-L1 blockade synergized with Tim-3/Tim-3L pathway blockade to restore the numbers of cytokine-producing and proliferating NY-ESO-1-specific CD4+ T cells. Collectively, our findings support the use of Tim-3/Tim-3L blockade in association with PD-1/PD-L1 blockade to reverse tumor-induced CD8+ and CD4+ T cell exhaustion/dysfunction in patients with advanced melanoma. Our findings have significant implication in terms of novel immunotherapeutic strategies aiming at promoting T cell-mediated tumor regression in patients with advanced cancers. This work was supported by NIH/NCI Grants CA90360 and CA112198 (HMZ) and Cancer Research Institute grant (HMZ). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3657. doi:10.1158/1538-7445.AM2011-3657
591 TERUTROBAN, A TXA2/PGH2 RECEPTOR ANTAGONIST, REDUCES PORTAL PRESSURE, AMELIORATES INTRAHEPATIC VASCULAR RESISTANCE AND INCREASES NITRIC OXIDE BIOAVAILABILITY IN CIRRHOTIC RAT LIVERS
Authors: E. Rosado, A. Rodriguez-Vilarrupla, J. Gracia-Sancho, H. García-Calderó, J. Bosch, J.C. García-Pagán
Journal: Journal of Hepatology (2012)
Abstract 3752: Induction of lung cancer stem-like cells by chronic exposure to carbon nanotubes.
Authors: Sudjit Luanpitpong, Liying Wang, Amruta Manke, Jamie Barr, Yon Rojanasakul
Journal: Cancer Research (2013)

Abstract Our previous studies have shown that chronic exposure to single-walled carbon nanotubes (SWCNTs) induces malignant transformation of human lung epithelial cells. Most solid tumors including lung cancer cells are believed to contain poorly differentiated cancer stem-like cells (CSCs) that initiate tumorigenesis and confer resistance to chemotherapy. In this study we investigated whether SWCNT-transformed lung epithelial cells present CSC traits. Similar to human non-small cell lung cancer H460 cells, SWCNT-transformed lung epithelial BEAS-2B cells but not its passage-matched control cells formed tumor spheres in stem cell-selective conditions, indicating the existence of lung CSCs. Lung CSCs have previously been reported to reside in the side population (SP) of parental lung cancer cells. Analysis of SP fractions based on the ability of SP to efflux Hoechst 33342 dye to generate a Hoechst blue-red profile revealed that the SWCNT-transformed cells and H460 cells have high SP fractions, while passage-matched control cells showed no SP, thus confirming the existence of CSC population in SWCNT-transformed and H460 cells. Compared with the corresponding parental cells, the SP cells of SWCNT-transformed and H460 cells acquired apoptosis resistance to various chemotherapy including antimycin A, cisplatin, doxorubicin and etoposide. Together, our results indicate the ability of SWCNT to transform human lung epithelial cells and induce CSCs which could represent a novel mechanism of carcinogenesis induced by CNTs. Citation Format: Sudjit Luanpitpong, Liying Wang, Amruta Manke, Jamie Barr, Yon Rojanasakul. Induction of lung cancer stem-like cells by chronic exposure to carbon nanotubes. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3752. doi:10.1158/1538-7445.AM2013-3752