tbuckley/cabot-search huggingface dataset:
Abstract LB-334: IFN-γ and TRAIL cooperate to enhance colon carcinoma apoptosis and immune cell-mediated anti-tumor cytotoxicity
Authors: Feiyan Liu, Kebin Liu
Journal: Cancer Research (2010)

Abstract Development of cancer-selective therapy with little or no toxicity is one of the goals of modern translation cancer research. TRAIL selectively induces apoptosis in various types of tumor cells but not in normal cells, and thereby is a promising selective anti-cancer agent. Currently, TRAIL is in early stage clinical trials for treatment of almost all types of human cancers. However, tumor cell resistance to TRAIL is a major impediment of TRAIL therapy. Most current approach to overcome TRAIL resistance is by pharmacologic means, which often involve use of toxic therapeutic agents. In this study, we demonstrated here that IFN-γ, a cytokine secreted by activated immune cells, modulate the mitochondrion apoptosis pathway to sensitize human colon carcinoma cells to TRAIL-induced apoptosis. IFN-γR is expressed in human colon carcinoma, and moderate to high positive correlations were found between cell surface IFN-γR level and TRAIL-induced apoptosis. Furthermore, activated CD8+ T cells express high levels of IFN-γ and TRAIL, and TRAIL is also expressed in tumor-infiltrating CD4+, CD8+ T cells, macrophage and NK cells. Consequently, blocking TRAIL function significantly increased colon carcinoma metastasis in vivo. Our data suggest that cooperation between IFN-γ and TRAIL play critical role in anti-tumor immunity. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-334.
Why not the first-person plural in social cognition?
Authors: Mattia Gallotti
Journal: Behavioral and Brain Sciences (2013)

Abstract Through the mental alignment that sustains social interactions, the minds of individuals are shared. One interpretation of shared intentionality involves the ability of individuals to perceive features of the action scene from the perspective of the group (the “ we -mode”). This first-person plural approach in social cognition is distinct from and preferable to the second-person approach proposed in the target article.
SP0037 Development and Evaluation of a Hospital-Based Webportal with Patient Access to Electronic Medical Records
Authors: R. Van Der Vaart
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objective</h3> Using a user-centered approach, a hospital-based Web portal was developed which provides rheumatology patients with information and access to their electronic medical records (EMR). In this presentation the developmental phases of the Web portal will be shortly explained and, subsequently, the evaluation results will be discussed. In the evaluation, the use, satisfaction and impact on empowerment of the web portal was assessed among patients with rheumatoid arthritis. <h3>Methods</h3> To evaluate the web portal, a pretest-posttest study among 360 patients was conducted. Questionnaires assessed patients' socio-demographics, health literacy, Internet use, disease characteristics, and "empowerment" before and after launching a hospital-based web portal. To measure empowerment, patients' satisfaction with care, trust in their rheumatologist, self-efficacy in patient-provider communication, illness perceptions, and medication adherence were assessed. The post-test included questions on web portal use, satisfaction, and self-perceived impact due to web portal use. <h3>Results</h3> 54% of respondents with Internet access had viewed their EMR. Respondents were positive about the ease of use and usefulness of the portal and reported very few problems. Age (<i>P</i>=.03), amount of Internet use (<i>P</i>=.01) and self-perceived Internet skills (<i>P</i>=.03) significantly predicted web portal use. Of the respondents who had logged in, 44% reported to feel more involved in their treatment and 37% felt they had more knowledge about their treatment. Significant differences over time were not found on the used instruments. <h3>Conclusion</h3> The current portal succeeded to offer patients access to their EMR in a usable and understandable way. While its impact is difficult to grasp, an evident part of patients feels more empowered due to the web portal. Offering patients home EMR access seems to be a valuable addition to the care process, with the potential to involve patients more in their own treatment. <h3>Disclosure of Interest</h3> None Declared
S26 What Are The Predictors Of Developing Hypoventilation In Obesity?
Authors: A. Manuel, N. Hart, J. Stradling
Journal: Thorax (2014)

<h3>Introduction</h3> Obesity Hypoventilation Syndrome (OHS) is conventionally defined by the combination of obesity (BMI &gt;30 kg/m<sup>2</sup>) and daytime hypercapnia (PaCO<sub>2</sub> &gt;6 kPa, with no alternative explanation); sleep-disordered breathing may or may not be included in the definition. The development of ventilatory failure in obese individuals is highly variable, and the additional factors responsible have not been comprehensively studied. In obese individuals, the presence of a raised plasma standard bicarbonate (or base excess, BE – a biomarker of whole body acid-base balance, including overnight PaCO<sub>2</sub> levels), without necessarily a raised daytime PaCO<sub>2</sub>, has been shown by us to be an intermediary stage towards overt obesity-hypoventilation syndrome. Thus we have looked for biologically plausible predictors of a raised base excess in obesity, whether or not there was also a raised PaCO<sub>2</sub> awake. <h3>Methods</h3> 78 obese subjects (BMI &gt;30, mean 47 (SD 10, range 32 to 74) kg/m<sup>2</sup>) were identified from a variety of sources, regardless of their PaCO2 and acid/base status (mean levels 5.6 (SD 0.8, range 4.2 to 9.6) kPa; and 2.1 (SD 2.4, range -3.5 to 10) mmol/l respectively) and a large number of their characteristics measured. Biological plausible domains were constructed that were thought potentially to contribute to any ventilatory failure. First, the best independent predictor of the BE within each domain was found, second, the best overall independent predictors were found. The domains were as follows: Obesity and its distribution (BMI, simple surface measures, DXA [a radiographic derivative]) Lung function (sitting/lying spirometry and forced oscillometry) Sleep variables (AHI, ODI, mean overnight SaO2, time below 90% SaO2) Ventilatory control (2 point responses to 15% O2 and 5% CO2) Respiratory muscle strength (mouth pressures, sniff pressures) Metabolic measures (e.g. leptin, adipokines, vitamin D) <h3>Conclusions</h3> There are a number of strong predictors for the presence of a raised base excess in obesity. Significant predictors were found in each of the biological domains we studied, suggesting that the cause of ventilatory failure in obesity is likely to be multifactorial. However, reduced hypoxic poikilocapnic ventilatory drive and the presence of intra-abdominal obesity seem to be the most powerful predictors of a raised base excess in obesity.
Case 38-2013
Authors: Alaka Ray, Victorine V. Muse, Daniel F. Boyer
Journal: New England Journal of Medicine (2013)

A 30-year-old man was admitted to the hospital because of fever, chills, and lymphadenopathy that developed 6 months after he returned from a trip to India. Imaging revealed diffuse lymphadenopathy in the neck and chest and splenomegaly. Diagnostic tests were performed.
PROGNOSTIC VALUE OF GLOBAL LONGITUDINAL STRAIN ASSESSED BY 3D SPECKLE TRACKING ECHOCARDIOGRAPHY IN ASYMPTOMATIC PATIENTS WITH SEVERE AORTIC STENOSIS
Authors: Yasufumi Nagata, Masaaki Takeuchi, Victor Chien-Chia Wu, Masaki Izumo, Kengo Suzuki, Kimi Sato, Yoshihiro Seo, Kyoko Otani, Yoshihiro Akashi, Kazutaka Aonuma, Yutaka Otsuji
Journal: Journal of the American College of Cardiology (2015)
Reliable and valid assessment of competence in endoscopic ultrasonography and fine-needle aspiration for mediastinal staging of non-small cell lung cancer
Authors: L. Konge, P. Vilmann, P. Clementsen, J. Annema, C. Ringsted
Journal: Endoscopy (2012)

<b>Background and study aims:</b> Fine-needle aspiration (FNA) guided by endoscopic ultrasonography (EUS) is important in mediastinal staging of non-small cell lung cancer (NSCLC). Training standards and implementation strategies of this technique are currently under discussion. The aim of this study was to explore the reliability and validity of a newly developed EUS Assessment Tool (EUSAT) designed to measure competence in EUS – FNA for mediastinal staging of NSCLC. <b>Patients and methods:</b> A total of 30 patients with proven or suspected NSCLC underwent EUS – FNA for mediastinal staging by three trainees and three experienced physicians. Their performances were assessed prospectively by three experts in EUS under direct observation and again 2 months later in a blinded fashion using digital video-recordings. Based on the assessments, intra-rater reliability, inter-rater reliability, and construct validity were explored. <b>Results:</b> The intra-rater reliability was good (Cronbach's α = 0.80), but comparison of results based on direct observations and blinded video-recordings indicated a significant bias favoring consultants (<i>P</i> = 0.022). Inter-rater reliability was very good (Cronbach's α = 0.93). However, one rater assessing five procedures or two raters each assessing four procedures were necessary to secure a generalizability coefficient of 0.80. The assessment tool demonstrated construct validity by discriminating between trainees and experienced physicians (<i>P</i> = 0.034). <b>Conclusions:</b> Competency in mediastinal staging of NSCLC using EUS and EUS – FNA can be assessed in a reliable and valid way using the EUSAT assessment tool. Measuring and defining competency and training requirements could improve EUS quality and benefit patient care.
Transdermal Nicotine as Maintenance Therapy for Ulcerative Colitis
Authors: Gareth A.O. Thomas, John Rhodes, Venk Mani, Geraint T. Williams, Robert G. Newcombe, Michael A.H. Russell, Colin Feyerabend
Journal: New England Journal of Medicine (1995)

Ulcerative colitis is largely a disease of nonsmokers. Having found previously that treatment with transdermal nicotine patches and mesalamine (5-aminosalicylic acid) has a beneficial effect on active colitis, we examined the value of transdermal nicotine for the maintenance of remission.We treated 80 patients with ulcerative colitis in remission with either transdermal nicotine or placebo patches for six months in a randomized, double-blind study. Incremental doses of nicotine were given for the first three weeks to achieve a maintenance dose; most patients tolerated 15 mg for 16 hours daily. All patients were taking mesalamine preparations as maintenance treatment at entry into the study; this treatment was stopped once the maintenance dose of nicotine was achieved. Clinical, sigmoidoscopic, and histologic assessments were made at the beginning and the end of the study, or at relapse. Side effects and serum nicotine and cotinine concentrations were monitored throughout the study.There was no significant difference in the number of relapses between the groups. Twenty-two patients in the nicotine group were prematurely withdrawn from the study, 14 because of relapse and 8 for other reasons, including side effects and protocol violations. In the placebo group, 20 patients were withdrawn prematurely, 17 because of relapse and 3 for other reasons. Among patients using 15-mg nicotine patches, serum nicotine and cotinine concentrations were lower than expected and may reflect poor compliance. Side effects were reported by 35 patients--21 in the nicotine group and 14 in the placebo group--the most common of which were nausea, lightheadedness, and itching.Transdermal nicotine alone was no better than placebo in the maintenance of remission of ulcerative colitis, and premature withdrawal due to side effects was more common in the nicotine group.
Abstract 3091: Oncogenic roles of nuclear VCP in oral cancer development
Authors: I-Wen Chiu, Chien-Feng Li, Chien-Chen Lai, Ming-Tsung Lai, Chih-Mei Chen, Ying-Ju Lin, Lei Wan, Hsien-Chang Tseng, Chun-Hung Hua, Ming-Hsui Tsai, Wei-Yi Hsu, Fuu-Jen Tsai, jim Jinn-Chyuan Sheu
Journal: Cancer Research (2010)

Abstract VCP is a member of AAA-ATPase family that includes putative ATP-binding proteins involved in nuclear envelope reconstruction, cell cycle regulation, Golgi reassembly, suppression of apoptosis, and DNA-damage response. Due to the novel functions, VCP overexpression was linked to cancer development and suggested as a prognostic tumor marker for poor clinical outcome. Our preliminary data of SNP array analysis on 33 fresh clinical OSCC samples identified an amplified region at chromosome 9p13.3 containing the VCP gene. This finding was further validated by FISH analysis on a larger scale using paraffin-embedded oral cancer tissues. Consistent with genomic copy alterations, the mRNA and protein expression levels of VCP were also found higher in OSCC tissues. Interestingly, the nuclear VCP staining correlates with VCP gene amplification and shorter overall survival, suggesting the novel functions of VCP in nucleus during OSCC development. In this study, we identified several nuclear binding partners for VCP in OSCC cells, and signaling networks controlled by VCP during OSCC development were discussed. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3091.
ECDC publishes updated evidence-based guidance for chlamydia prevention and control and makes latest chlamydia figures available online through interactive Surveillance Atlas
Authors: O Mardh, AJ Amato-Gauci
Journal: Eurosurveillance (2016)

Preview this article: ECDC publishes updated evidence-based guidance for chlamydia prevention and control and makes latest chlamydia figures available online through interactive Surveillance Atlas, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/21/10/eurosurv-21-30157-7-1.gif
Cholecystoduodenal fistula diagnosed with contrast-enhanced endoscopic ultrasound
Authors: M. Velosa, S. Lopes, R. Castro, G. Macedo
Journal: Endoscopy (2013)

A 58-year-old man with a history of Crohn's disease (A2L2B1 p), bile stones, migraine, and chronic depression presented with an 11-kg weight loss and asthenia during the preceding 6 months. He was receiving treatment with infliximab, azathioprine, mirtazapine, and lorazepam. Laboratory tests showed a slightly elevated C-reactive protein (CRP) of 35 mg/dL. He underwent a computed tomography (CT) scan that demonstrated gallbladder-wall calcification, with no cleavage plane between the second portion of the duodenum and the gallbladder ([Fig. 1]).
IMPACT OF CLINICAL DEMOGRAPHICS ON THREE YEAR FREEDOM FROM ATRIAL FIBRILLATION AFTER ABLATION GUIDED BY ROTORS OR FOCAL SOURCES VERSUS CONVENTIONAL ABLATION ALONE: LONG TERM ANALYSIS OF THE CONFIRM TRIAL
Authors: Tina Baykaner, Paul Clopton, Amir Schricker, Gautam Lalani, Kalyanam Shivkumar, John Miller, David Krummen, Sanjiv Narayan
Journal: Journal of the American College of Cardiology (2014)
Improvement in clinical recording keeping following the introduction of an admission clerking proforma for acute general surgical patients
Authors: Shradha Gupta, Kumaran Ratnasingham, Veena Bhargava, Nick West
Journal: International Journal of Surgery (2013)

s / International Journal of Surgery 11 (2013) 589e685 647 ABSTRACTS Patientswho had suspectedmidface fractures, radiographs taken in A&E and who underwent a review in OMFS clinics were selected. Patients who failed to attend, had incomplete records or had additional injuries were excluded. The agreement between the A&E diagnosis, the A&E radiograph report and the subsequent OMFS review was compared. Results: 103 patients were included. The clinical A&E referral diagnosis agreed with the OMFS diagnosis only 26% of the time while the A&E radiograph report agreed with the OMFS clinical diagnosis on 63% of occasions. Conclusion: The clinical diagnosis alone by A&E clinicians relating to mid face fractures poorly correlates with the final diagnosis. A&E Radiograph reports should be taken into consideration by A&E clinicians in diagnosing mid face fractures. We review the findings and injury patterns.
1373 VITAMIN D DEFICIENCY IS ASSOCIATED WITH SEVERITY AND MORTALITY, AND MAY WORSEN INFLAMMATION AND FIBROSIS, IN ALCOHOLIC LIVER DISEASE
Authors: E. Trépo, R. Ouziel, P. Pradat, Y. Momozawa, E. Quertinmont, C. Gervy, T. Gustot, D. Degré, V. Vercruysse, P. Deltenre, B. Gulbis, D. Franchimont, J. Deviere, A. Lemmers
Journal: Journal of Hepatology (2012)
Low-Dose Aspirin to Prevent Preeclampsia in Women at High Risk
Authors: Steve Caritis, Baha Sibai, John Hauth, Marshall D. Lindheimer, Mark Klebanoff, Elizabeth Thom, Peter VanDorsten, Mark Landon, Richard Paul, Menachem Miodovnik, Paul Meis, Gary Thurnau, Sidney Bottoms, Donald McNellis, James M. Roberts
Journal: New England Journal of Medicine (1998)

Whether low-dose aspirin prevents preeclampsia is unclear. It is not recommended as prophylaxis in women at low risk for preeclampsia but may reduce the incidence of the disease in women at high risk.
AB0630 Gout and hypertension. role of hyperuricemia in the development of hypertension.
Authors: E. Mikhnevich, C. Mytnik
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The most of patients with gout have various associated diseases, from which hypertension (HTN) has an important prognostic value. The role of hyperuricemia (HUE) in the development of HTN remains a subject of the discussions. <h3>Objectives</h3> To study the factors, which participate in the formation of HTN in gout; to determine the associations between the risk factors, parameters of severity of HTN and uricemia. <h3>Methods</h3> 358 patients with the gouty arthritis (GA), admitted to the Rheumatology Unit during 2009-2012, filled classification criteria of the acute GA (1977, ACR). 285 (79,6%) patients had HTN. The co-morbidities: ischemic heart disease -120 (33,5 %) patients, diabetes-56 (15,6 %) patients, chronic kidney disease - 182 (50,8 %) patients, vascular coronary and cerebral accidents – 41 (11,5 %) patients. We chose 73 patients from the group with primary gout and concomitant HTN (group HTN+) and 73 patients (20,4 %) without HTN ( group HTN-), comparable in sex, age and duration of gout. Characteristics of gout and HTN were compared between the groups HTN+ and HTN-. We studied the correlation links between the serum levels of acid uric and the risk factors, parameters of severity of HTN. <h3>Results</h3> Among patients with HTN+ diabetes was more often observed, than in group without HTN (OR-2,6; 95%CI, 0,98-6,92; p&lt; 0,05). Compared with patients from group HTN-, patients from group HTN+ had higher rates of ischemic heart disease (OR-3,29; 95 %Cl, 1,5-7,2; p&lt; 0,001). In the patients of group HTN+ we also found statistically higher number of the cases of excess weight and obesity (OR-5,54; 95%CI, 4,90-6,25; p&lt;0,05). No differences between the groups were noted in the serum levels of uric acid (HTN- 576±180 mmol/l vs HTN+ 537±123 mmol/l, p&gt; 0,05). Glomerular filtration rate and the level of the serum creatinine were similar in both groups. We defined the direct statistically significant correlation links between the serum levels of acid uric and triglycerides in the general group (r=0,66) and in the group HTN- (r=0,52). No parameters of characteristics of HTN were correlated with the serum level of acid uric. <h3>Conclusions</h3> In clinical setting the majority of patients with gouty arthritis have hypertension- 79,6%. The serum level of uric acid in patients with gout is closely linked with the serum level of triglycerides. The development of hypertension in patients with gout is associated with diabetes, excess weight and obesity as well as ischemic heart disease. The direct role of hyperuricemia was not confirmed in it. <h3>Disclosure of Interest</h3> None Declared
THU0432 Efficiency of Guided Discovertebral Biopsy in Infectious Spondylodiscitis
Authors: I. Mahmoud, A. Andia, O. Saidane, A. Ali, R. Tekaya, H. Sahli, L. abdelmoula, R. Zouari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Etiologic diagnosis is important for treatment and consequently for the prognosis of the patient with infectious spondylodiscitis. Unfortunately, this diagnosis can be difficult and the need of a guided discovertebral biopsy (GDVB) could be helpful. <h3>Objectives</h3> The purpose of this retrospective study was to assess the performance of GDVB to determine the etiology of infectious spondylodiscitis. <h3>Methods</h3> Patients hospitalized in Rheumatology department, between 1999 to 2012, for suspected diagnosis of infectious spondilodiscitis has been collected. Only patients who had a GDVB for etiologic diagnosis of infectious spondylodiscitis were included in this study. <h3>Results</h3> 60 patients were included. The accurate arguments diagnosis was obtained in 32 %. Then GDVB was profitable for tuberculosis by: tuberculosis culture, necrosis caseum with giganted cells in 17 % of case; for pyogenes germs it was also profitable in 15% (four cases for staphylococcus aureus one case for brucellosis, one case for Klebsiella oxytoca, one case for Serratia Marcescens, two cases for E.coili ). In 40 % of case the results was no specific with an inflammatory involvement in histopathologic exam: with a definitive diagnosis of tuberculosis in 20 cases and brucellosis in 4 cases. In 28% of case the results was without particularity, non interpretable or non transmitted (major case for tuberculosis, and brucellosis and pyogenes germs for the rest). <h3>Conclusions</h3> Guided discovertebral biopsy is helpful for the diagnosis of infectious spondylodiscitis and should be done whenever this condition is suspected. The increased rates for no specific inflammatory involvement and no interpretable results could be reduced by respecting the guided discovertebral biopsy technical in order to biopsy the real lesions for different exams. <h3>Disclosure of Interest</h3> None Declared
SP0180 How do We Treat Early Ssc: Consequences for Clinical Practice
Authors: D. Khanna
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Systemic sclerosis (SSc) has the highest case-specific mortality of any of the auto-immune rheumatic diseases, as well as causing major morbidity. There are emerging data supporting efficacy for some treatment approaches for early patient group together with a growing number of exciting potential novel approaches to treatment that are moving into the clinical arena. This presentation will discuss practical management of early SSc in clinical practice. <h3>Disclosure of Interest</h3> D. Khanna Grant/Research support from: Actelion, Astra-Zeneca, Bayer, Biogen-Idec, BMS, DIGNA, Genentech/Roche, Gilead, InterMune, Merck, Takeda, Sanofi-Aventis, Savient, and United Therapeutics, Consultant for: NIH, Scleroderma Foundation, Pulmonary Hypertension Association <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6246