tbuckley/cabot-search huggingface dataset:
“Prolonged grief disorder” and “persistent complex bereavement disorder”, but not “complicated grief”, are one and the same diagnostic entity: an analysis of data from the Yale Bereavement Study
Authors: Paul K. Maciejewski, Andreas Maercker, Paul A. Boelen, Holly G. Prigerson
Journal: World Psychiatry (2016)

There exists a general consensus that prolonged grief disorder (PGD), or some variant of PGD, represents a distinct mental disorder worthy of diagnosis and treatment. Nevertheless, confusion remains over whether different names and proposed symptom criteria for this disorder identify the same or different diagnostic entities. This study aimed to determine whether PGD, complicated grief (CG), and persistent complex bereavement disorder (PCBD) as described by the DSM-5 are substantively or merely semantically different diagnostic entities. Data were derived from the Yale Bereavement Study, a longitudinal community-based study of bereaved individuals funded by the US National Institute of Mental Health, designed explicitly to evaluate diagnostic criteria for disordered grief. The results suggested that the difference between PGD and PCBD is only semantic. The level of agreement between the original PGD test, a new version of the PGD test proposed for ICD-11 and the PCBD test was high (pairwise kappa coefficients = 0.80-0.84). Their estimates of rate of disorder in this community sample were similarly low (∼10%). Their levels of diagnostic specificity were comparably high (95.0-98.3%). Their predictive validity was comparable. In contrast, the test for CG had only moderate agreement with those for PGD and PCBD; its estimate of rate of disorder was three-fold higher (∼30%); its diagnostic specificity was poorer, and it had no predictive validity. We conclude that PGD, PCBD and proposed ICD-11, but not CG, symptom-diagnostic tests identify a single diagnostic entity. Ultimately, brief symptom-diagnostic tests, such as the one proposed here for ICD-11, may have the greatest clinical utility.
Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis
Authors: Dagmar M. Ouweneel, Jasper V. Schotborgh, Jacqueline Limpens, Krischan D. Sjauw, A. E. Engström, Wim K. Lagrand, Thomas G. V. Cherpanath, Antoine H. G. Driessen, Bas A. J. M. de Mol, José P. S. Henriques
Journal: Intensive Care Medicine (2016)
Augmented Consolidation Therapy Based on Minimal Residual Disease (MRD) and Analysis of the Measurement of Sequential MRD in Childhood Acute Lymphoblastic Leukemia : Children's Cancer and Leukemia Study Group of JAPAN (CCLSG), Cclsg ALL 2004 Protocol Study
Authors: Arata Watanabe, Toshinori Hori, Yasuto Shimomura, Chihaya Imai, Atsushi Ogawa, Motoaki Chin, Hiroyuki Shichino, Yasuo Horikoshi, Keiko Nomura, Yutaka Saikawa, Shouhei Yokota, Akiko Inoue, Takashi Taga, Masahiko Okada, Jun-ichi Ueyama, Asayuki Iwai, Michihiro Yano, Yasuhiro Okamoto, Masahito Tsurusawa, Atsushi Kikuta
Journal: Blood (2015)
Prevalence of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Large Population Cohort in the North of the Netherlands: A Lifelines Cohort Study
Authors: E.H. van den Berg, M. Amini, T.C.M.A. Schreuder, R.P.F. Dullaart, K.N. Faber, B.Z. Alizadeh, H. Blokzijl
Journal: Journal of Hepatology (2016)
Case 45-1979
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Charles B. Carpenter, Walter P. Richardson
Journal: New England Journal of Medicine (1979)

Presentation of CaseA 44-year-old man was admitted to the hospital because of renal dysfunction.He was well until the age of 17 years, when proteinuria was found during an insurance examination. When he was 22 years old the nonprotein nitrogen was 30 mg per 100 ml. On an intravenous pyelographic examination the right kidney and ureter were not visualized on any films; there was prompt opacification of the left kidney; the calyxes, ureter and bladder appeared normal. A retrograde pyelographic study disclosed normal left calyxes, pelvis and ureter; the right ureter was not demonstrated. At the age of 25 . . .
Non-Invasive Evaluation of Chronic Hepatitis C Patients with Moderate Fibrosis (F2) Long-Term Impact of Antiviral Treatment
Authors: J.A. Carrión, N. Cañete, M. Puigvehí, M. Garcia, M. García-Retortillo, J. Gimeno, T. Broquetas, S. Coll, R. Fernández, B. Cabrero, M.D. Giménez, F. Bory, R. Solà
Journal: Journal of Hepatology (2016)
Cuts to social care funding represent urgent threat to the NHS, warn experts
Authors: Adrian O’Dowd
Journal: BMJ (2016)

Successive cuts to local authority budgets are leading to serious gaps in social care availability to older people and are putting significant strain on the NHS, according to a new report by health think tanks the King’s Fund and the Nuffield Trust.1

The report, Social Care for Older People: Home Truths, published on 15 September said that older people were paying the price for cuts to social care and any help they might receive increasingly depended on where they lived and how much money they had, rather than their needs.

Both think tanks said that six consecutive years of cuts to local authority budgets by …
Chronic Stress Facilitates Lung Tumorigenesis by Promoting Exocytosis of IGF2 in Lung Epithelial Cells
Authors: Hyun-Ji Jang, Hye-Jin Boo, Ho Jin Lee, Hye-Young Min, Ho-Young Lee
Journal: Cancer Research (2016)

Molecular insights into how chronic stress affects lung tumorigenesis may offer new routes to chemoprevention. In this study, we show that chronic stress in mice chemically or genetically initiated for lung cancer leads to the release of norepinephrine and other catecholamines, thereby promoting lung tumorigenesis. Mechanistically, norepinephrine induced phosphorylation of L-type voltage-dependent calcium channels (VDCC) through the β-adrenergic receptor-PKA pathway. VDCC triggered calcium mobilization, thereby inducing activation of IGF-1R via exocytosis of insulin-like growth factor 2 (IGF2). Mice expressing lung-specific IGF-1R exhibited accelerated lung tumor development in response to chronic stress. Notably, clinically approved antihypertensive drugs that block L-type VDCC prevented the effects of chronic stress or norepinephrine on the IGF2/IGF-1R signaling cascade, along with transformation of lung epithelial cells and lung tumor formation. Overall, our results identify an actionable mechanism to limit the effects of chronic stress on lung tumorigenesis. Cancer Res; 76(22); 6607-19. ©2016 AACR.
Cerebrospinal Fluid Biomarkers in Postconcussion Syndrome
Authors: Robert A. Stern
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Review: In severe aortic stenosis, TAVI and conventional surgery do not differ for ≤ 30-day or ≤ 1-year mortality
Authors: Per Olav Vandvik, Gordon Guyatt
Journal: Annals of Internal Medicine (2016)

Source Citation Gargiulo G, Sannino A, Capodanno D, et al. Transcatheter aortic valve implantation versus surgical aortic valve replacement: a systematic review and meta-analysis. Ann Intern Med. 2016 Jun 7. [Epub ahead of print] 27272666
Phase I study of LBH589 in combination with erlotinib for advanced aerodigestive tract cancers.
Authors: J. E. Gray, E. B. Haura, A. Chiappori, T. Tanvetyanon, C. C. Williams, M. C. Pinder, A. Neuger, J. L. Giglia, G. Bepler, S. Altiok
Journal: Journal of Clinical Oncology (2010)

e13016 Background: It has previously been demonstrated that the addition of LBH589 (L) to erlotinib (E) can enhance the therapeutic efficacy of E and overcome resistance to this drug. Results of the combination of L and E in patients with non-small cell lung cancer (NSCLC) and head and neck cancer are presented. Methods: To determine the maximum tolerated dose and phase II dose of L+E and to evaluate toxicity, efficacy, and pharmacodynamic markers, a phase I study in previously treated patients with NSCLC and head and neck cancer was conducted. L was given twice weekly, 1 week off, 2 weeks on with daily E: dose level 1 (DL1), L 20 mg + E 100 mg; DL2, L 30 mg + E 100 mg; DL3, L 30 mg + E 150 mg. Erlotinib PK analysis was performed. Pre- and post-tumor fine needle aspiration (FNA) biopsy in selected patients and PBMCs and subcutaneous fat pad (FP) biopsy were collected from all participants to assess patient response in vivo. Results: 15 patients were enrolled (3, 6, and 6 in consecutive dose levels). Average age was 64.2 (range: 52-79 ) years, with 8 (53%) females, PS: 0-1, 14 (93%) NSCLC, 1.4 prior regimens, and 1 EGFR mutation vs. 6 WT vs. 8 unknown. Total number of cycles was 52.3 (average: 3.5, range 1-13). Of 12 evaluable patients, 7 had SD and 5 had PD. One patient who previously progressed on E alone remained on study for 39 weeks with SD. The most common toxicities were rash (73%), nausea (67%), fatigue (67%), and diarrhea (47%). Grade 3/4 toxicities included nausea, neutropenia, and QTc prolongation. Dose-limiting toxicities were atrial fibrillation (DL2), prolonged QTc (DL3), and nausea (DL3). Neither first exposure L nor steady-state concentrations of L affected levels of E. Western blot analyses demonstrated histone and tubulin acetylation in tumor, PBMC, and FP samples. All three PD markers closely correlated with therapy response. Conclusions: The phase II dose of L (30 mg twice weekly for 2 weeks) and E (100 mg daily) has been defined. The combination is well tolerated. We showed that FP could be used as a surrogate tissue to assess HDAC inhibition in vivo. The phase I dose expansion study and further PK analyses and pharmacodynamic assays are underway. No significant financial relationships to disclose.
Salvage Therapy with Chemotherapy- or Arsenic Trioxide-Based Regimens for Acute Promyelocytic Leukemia in First Relapse.
Authors: Pau Montesinos, Jordi Esteve, Edo Vellenga, Concha Rivas, Salut Brunet, Montserrat Arnan, Jose D. Gonzalez, Pedro Sanchez, Joaquín Díaz-Mediavilla, Amparo Verdeguer, Lourdes Escoda, Elena Amutio, Vicente Rubio, Inmaculada Perez, Ramon Guardia, Javier Bueno, Bob Lowenberg, Miguel A. Sanz
Journal: Blood (2009)
SNP rs34172460 (S258A)Â in Gene CIP2A Correlates with Bortezomib Resistance in Multiple Myeloma Patients
Authors: George Tang, Mingjie Li, Eric Sanchez, Cathy Wang, Suzie Vardanyan, Tiffany Lee, Jason Nosrati, Jasmin Cao, Michael Zahab, Puja Mehta, Gigi Garzio, Haiming Chen, James Berenson
Journal: Blood (2015)
PNPLA3 Variants Confer an Increased Risk of Advanced Fibrosis Due to Non-Alcoholic Steatohepatitis
Authors: P.R. Shea, A. Sanyal, S. Harrison, V. Ratziu, R. Loomba, S. Caldwell, A.M. Diehl, S.E. Kleinstein, R.P. Myers, G. Mani Subramanian, J.G. McHutchison, M.F. Abdelmalek, J. Bosch, N. Afdhal, D.B. Goldstein
Journal: Journal of Hepatology (2016)
Combination Of Fluorescence In SITU Hybridization (FISH) and Cytogenetic Techniques Optimize The Diagnostic Process Of Patients With Myelodysplastic Syndrome (MDS)
Authors: Drorit Merkel, Ilia Navikov, Abraham Avigdor, Ninette Amariglio, Arnon Nagler, Luba Trakhtenbrot
Journal: Blood (2013)
P0569 : Liver inflammasome expression signaling may be activated in patients with chronic hepatitis B and repressed during long term antiviral treatment
Authors: G. Germanidis, A. Molyvdas, N. Lasaridis, T. Vassiliadis, A. Voumvouraki, E. Laspa, A.E. Germenis, M. Speletas
Journal: Journal of Hepatology (2015)
Virological Failures to New Direct Acting Antivirals in a Real Life Setting May Require Unconventional Regimens for Re-Treatment
Authors: V.C. Di Maio, V. Cento, D. Di Paolo, I. Lenci, M. Aragri, G. Verucchi, M. Melis, A. Bertoli, F.P. Antonucci, S. Francioso, A. Pellicelli, V. Calvaruso, C. Pasquazzi, D. Romagnoli, M. Biolato, J. Vecchiet, F. Morisco, M. Merli, G.B. Gaeta, S. Brillanti, F. Donato, M. Puoti, V. Pisani, M. Paoloni, S. Babudieri, A. Craxì, M. Angelico, C.F. Perno, F. Ceccherini-Silberstein
Journal: Journal of Hepatology (2016)
Methylglyoxal in Metabolic Disorders: Facts, Myths, and Promises
Authors: Paulo Matafome, Tiago Rodrigues, Cristina Sena, Raquel Seiça
Journal: Medicinal Research Reviews (2016)

Abstract Glucose and fructose metabolism originates the highly reactive byproduct methylglyoxal (MG), which is a strong precursor of advanced glycation end products (AGE). The MG has been implicated in classical diabetic complications such as retinopathy, nephropathy, and neuropathy, but has also been recently associated with cardiovascular diseases and central nervous system disorders such as cerebrovascular diseases and dementia. Recent studies even suggested its involvement in insulin resistance and beta‐cell dysfunction, contributing to the early development of type 2 diabetes and creating a vicious circle between glycation and hyperglycemia. Despite several drugs and natural compounds have been identified in the last years in order to scavenge MG and inhibit AGE formation, we are still far from having an effective strategy to prevent MG‐induced mechanisms. This review summarizes the endogenous and exogenous sources of MG, also addressing the current controversy about the importance of exogenous MG sources. The mechanisms by which MG changes cell behavior and its involvement in type 2 diabetes development and complications and the pathophysiological implication are also summarized. Particular emphasis will be given to pathophysiological relevance of studies using higher MG doses, which may have produced biased results. Finally, we also overview the current knowledge about detoxification strategies, including modulation of endogenous enzymatic systems and exogenous compounds able to inhibit MG effects on biological systems.
Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways
Authors: Seong M. Kim, Saurabh G. Roy, Bin Chen, Tiffany M. Nguyen, Ryan J. McMonigle, Alison N. McCracken, Yanling Zhang, Satoshi Kofuji, Jue Hou, Elizabeth Selwan, Brendan T. Finicle, Tricia T. Nguyen, Archna Ravi, Manuel U. Ramirez, Tim Wiher, Garret G. Guenther, Mari Kono, Atsuo T. Sasaki, Lois S. Weisman, Eric O. Potma, Bruce J. Tromberg, Robert A. Edwards, Stephen Hanessian, Aimee L. Edinger
Journal: Journal of Clinical Investigation (2016)

Oncogenic mutations drive anabolic metabolism, creating a dependency on nutrient influx through transporters, receptors, and macropinocytosis. While sphingolipids suppress tumor growth by downregulating nutrient transporters, macropinocytosis and autophagy still provide cancer cells with fuel. Therapeutics that simultaneously disrupt these parallel nutrient access pathways have potential as powerful starvation agents. Here, we describe a water-soluble, orally bioavailable synthetic sphingolipid, SH-BC-893, that triggers nutrient transporter internalization and also blocks lysosome-dependent nutrient generation pathways. SH-BC-893 activated protein phosphatase 2A (PP2A), leading to mislocalization of the lipid kinase PIKfyve. The concomitant mislocalization of the PIKfyve product PI(3,5)P2 triggered cytosolic vacuolation and blocked lysosomal fusion reactions essential for LDL, autophagosome, and macropinosome degradation. By simultaneously limiting access to both extracellular and intracellular nutrients, SH-BC-893 selectively killed cells expressing an activated form of the anabolic oncogene Ras in vitro and in vivo. However, slower-growing, autochthonous PTEN-deficient prostate tumors that did not exhibit a classic Warburg phenotype were equally sensitive. Remarkably, normal proliferative tissues were unaffected by doses of SH-BC-893 that profoundly inhibited tumor growth. These studies demonstrate that simultaneously blocking parallel nutrient access pathways with sphingolipid-based drugs is broadly effective and cancer selective, suggesting a potential strategy for overcoming the resistance conferred by tumor heterogeneity.
Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine
Authors: M. Elizabeth Fini, Stephen G. Schwartz, Xiaoyi Gao, Shinwu Jeong, Nitin Patel, Tatsuo Itakura, Marianne O. Price, Francis W. Price, Rohit Varma, W. Daniel Stamer
Journal: Progress in Retinal and Eye Research (2016)
Identification and validation of gene expression subtypes in a large set of colorectal cancer samples.
Authors: Eva Budinska, Vlad Calin Popovici, Katarzyna Otylia Sikora, Nicolas Lapique, Sabine Tejpar, John Graeme Hodgson, Scott Weinrich, Arnaud Roth, Fred Bosman, Mauro Delorenzi
Journal: Journal of Clinical Oncology (2012)

3511 Background: From a clinical perspective colorectal cancer (CRC) is a heterogeneous disease whose biological background is insufficiently understood. In order to adapt targeted treatment to biologically different categories of CRC patients, in depth understanding of the molecular mechanisms involved in CRC heterogeneity is urgently needed. Methods: Consensus cluster analysis of 1113 stage II-III CRC gene expression profiles from PETACC3 and 4 public datasets defined a set of subtypes which were confirmed in an independent set of 720 samples. The similarity between tumors was based on a set of 54 meta-genes. This approach improves the robustness to measurement noise and gives equal chances to each biological process to be accounted for in the subtype definition. We tested the association of the subtypes with clinical variables, molecular markers and patient survival. Results: We identified and validated 5 major subtypes A-E, with different levels of expression in 6 main molecular processes: epithelial-mesenchymal transition (EMT), immune response, colon crypt differentiation, proliferation, Wnt signaling and chromosome 20q. Significant differences in survival and an enrichment for markers such as MSI, BRAF mutation, site or p53 status were found between the subtypes. In addition, the new subtype classification uncovered heterogeneity within groups defined by these commonly used markers. Survival analysis showed significant prognostic value for meta-genes connected to EMT, proliferation and differentiation. Identical data processing and clustering applied to the validation set on the same meta-genes resulted in subtypes with almost identical expression patterns. Conclusions: We identified and validated robust molecular subtypes in the largest set of stage II-III CRC samples as a combination of multiple molecular processes, that complement current disease stratification based on clinico-pathological variables and molecular markers. The biological relevance of these subtypes was reflected in significant differences in survival. These insights open new perspectives for improving prognostic models and rationalize the prediction of tumor-specific drug sensitivity.
Systemic Inflammatory Response Profile in Acute-on-Chronic Liver Failure and its Relationship with Prognosis
Authors: C. Sole, E. Sola, M. Morales-Ruiz, G. Fernàndez, P. Huelin, I. Graupera, R. Moreira, G. De Prada, X. Ariza, E. Pose, N. Fabrellas, S. Kalko, W. Jiménez, P. Ginès
Journal: Journal of Hepatology (2016)
The End of Life for Patients with Acute Myeloid Leukemia (AML)- a Single Center Experience
Authors: Judy Foster, Traci M. Blonquist, Areej El-Jawahri, Amir T Fathi, Philip C. Amrein, Hossein Sadrzadeh, Andrew M. Brunner, Gabriella Hobbs, Eyal C. Attar, Donna S Neuberg, Karen K. Ballen
Journal: Blood (2015)
The Beneficial Impact of Rifaximin on Systemic and Intestinal Inflammation and Ammonia Occurs even without Microbiota: More than an Antibiotic
Authors: D.J. Kang, R. Balfour Sartor, N. Betrapally, H. Nittono, J. Herzog, P. Hylemon, M. SIkaroodi, P. Gillevet, I. Carroll, G. Kakiyama, H. Zhou, J. Yang, C. Jiao, S. Fan, O. Fiehn, H. Takei, W. Pandak, J.S.S. Bajaj
Journal: Journal of Hepatology (2016)
Ledipasvir/Sofosbuvir Treatment for 8 Weeks in Treatment-Naïve HCV Genotype 1 Infected Patients under Real Life Conditions: Data from the German Hepatitis C-Registry (DHC-R)
Authors: P. Buggisch, K.H.W. Böker, R. Günther, G. Teuber, H. Klinker, A. Pathil, S. Christensen, H. Peiffer-Vornkahl, K.-G. Simon, C. Niederau, H. Wedemeyer, S. Zeuzem
Journal: Journal of Hepatology (2016)
Effects Of Noninherited Maternal Antigen On The Occurrence Of Acute Graft-Versus Host Diseae After Unmanipulated Haploidentical Blood and Marrow Transplantation
Authors: Ying-Jun Chang, Dai-Hong Liu, Kaiyan Liu, Lan-Ping Xu, Yu Wang, Ming-Rui Huo, Huan Chen, Wei Han, Yu-Hong Chen, Feng-Rong Wang, Jing-Zhi Wang, Yao Chen, Chen-Hua Yan, Xiao-Jun Huang
Journal: Blood (2013)
Peripheral stem cells are the preferred source of stem cells for autologous stem cell transplantation (ASCT) of young patients with MDS or AML following MDS: An analysis of the chronic leukaemia working party of the European blood and marrow transplantation group (EBMT)
Authors: T de Witte, R Brand, A van Biezen, Michel Delforge, Runde, R Or, W Arcese, B Bandini, J Sierra, JY Cahn, M Michallet, S Amadori, D Niederwieser, A Gratwohl, JP Laporte
Journal: Blood (2001)
In Toxic Cirrhotic Rats, the FXR Agonist Obeticholic Acid Reduces Liver Fibrosis Indirectly via an Anti-Inflammatory Effect in Liver Sinusoidal Endothelial Cells and Kupffer Cells
Authors: L.D. Verbeke, I. Mannaerts, R. Schierwagen, O. Govaere, S. Klein, I.V. Elst, P. Windmolders, R. Farre, M. Wenes, M. Mazzone, F. Nevens, L. van Grunsven, J. Trebicka, W. Laleman
Journal: Journal of Hepatology (2016)
Cell Sheet Translocation: Facile Cell Sheet Harvest and Translocation Mediated by a Thermally Expandable Hydrogel with Controlled Cell Adhesion (Adv. Healthcare Mater. 18/2016)
Authors: Yu Bin Lee, Young Min Shin, Eun Mi Kim, Jangsoo Lim, Joong‐Yup Lee, Heungsoo Shin
Journal: Advanced Healthcare Materials (2016)

Heungsoo Shin and co-workers report a facile cell sheet harvesting platform based on thermally expandable hydrogels with modular cell adhesion property on page 2320. Delicate control of mussel-inspired adhesive coating polydopamine on the hydrogel enables stable cell sheet formation, and its detachment mediated by thermal expansion of the hydrogel, which holds numerous applications in regenerative medicine.