tbuckley/cabot-search huggingface dataset:
Influence of Diabetes on 5-Year Mortality and Morbidity in a Randomized Trial Comparing CABG and PTCA in Patients With Multivessel Disease
Authors: The BARI Investigators
Journal: Circulation (1997)

Background Patients with diabetes mellitus have increased morbidity and mortality after coronary revascularization. The Bypass Angioplasty Revascularization Investigation (BARI), a trial of percutaneous transluminal coronary angioplasty (PTCA) versus coronary artery bypass graft surgery (CABG) in patients with multivessel disease, reported a 5-year survival advantage of CABG over PTCA in patients with treated diabetes mellitus (TDM). This report examines these findings in more detail. Methods and Results Eighteen clinical centers randomly assigned 1829 patients with multivessel coronary disease to undergo initial CABG or PTCA. Patients were followed an average of 5.4 years. TDM was defined as a history of diabetes with use of oral hypoglycemic agents or insulin at study entry. Nineteen percent of the randomized population (353 patients) met these criteria. TDM patients had more unfavorable baseline characteristics than other patients, but among TDM patients, these characteristics were similar between the CABG and PTCA groups. Better average 5.4-year survival with CABG was due to reduced cardiac mortality (5.8% versus 20.6%, P =.0003), which was confined to those receiving at least one internal mammary artery graft. Conclusions Patients with TDM assigned to an initial strategy of CABG have a striking reduction in cardiac mortality compared with PTCA. Long-term internal mammary artery graft patency may contribute to this improved outcome by reducing the fatality of follow-up myocardial infarction.
Abstract 3309: Identifying glycoproteins in ER+ and ER- human breast cancer tissue samples
Authors: Suzan Semaan, Xu Eddy Wang, R. Emmett, Alan G. Marshall, Qing-Xiang Amy Sang
Journal: Cancer Research (2010)

Abstract Breast cancer is the second leading cause of death from cancer in women. New biomarkers for cancer detection and treatment are needed to increase the life expectancy of breast cancer patients. Protein glycosylation is a post translational modification that gives a protein a new function. A change in the glycosylation on a glycoprotein often causes a change in function of that glycoprotein and such phenomenon has been correlated with cancerous transformation. Thus, glycoproteins in human breast cancer estrogen receptor positive (ER+) tissue and those in estrogen receptor negative (ER-) tissue, the more aggressive stage in breast cancer, are compared and a list of glycoproteins possibly showing a difference in their glycosylation were identified using double staining (glyco- and total protein staining) of the 2-DE gels followed by ESI-FTICR analysis and gel spot count was done using ImageQuant TL. Results show that 30% of the total lysate proteins are glycoproteins, where the total proteins in ER+ are slightly higher than that of the ER-, yet the difference between the glycoprotein in the ER+ and ER- is not significant. Alpha-1-acid glycoprotein, Alpha-1-antitrypsin glycoprotein, Annexin A1, Malate dehydrogenase mitochondrial precursor, Myosin-reactive immunoglobulin kappa chain variable region, IGKV1-5, Peroxiredoxin-1, and Superoxide dismutase mitochondrial precursor are the identified glycoproteins in both ER+ and ER- human breast tissue samples. Alpha-1-acid glycoprotein and Alpha-1-antitrypsin glycoprotein are mostly N-glycosylated proteins. Annexin A1, Malate dehydrogenase mitochondrial precursor, and Superoxide dismutase mitochondrial precursor are possibly N- or O-glycoslated proteins, while Myosin-reactive immunoglobulin kappa chain variable region, IGKV1-5, and Peroxiredoxin-1 are possibly mostly O-glycosylated proteins. Among those glycoproteins Alpha-1-acid glycoprotein, Alpha-1-antitrypsin glycoprotein, Annexin A1, Peroxiredoxin-1, Immunoglobulin gamma-1C region, and Superoxide dismutase mitochondrial precursor are important glycoproteins in breast cancer and possible biomarkers during the progression of human breast cancer. (This work was supported in part by grant BCTR0504465 from the Susan G. Komen for the Cure Breast Cancer Foundation, grants from the Florida Breast Cancer Coalition Research Foundation, the Elsa U. Pardee Foundation, and the Florida State University to Prof. Q.-X. Sang) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3309.
ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE (ALCAM) AND OUTCOMES IN ACUTE CORONARY SYNDROMES: A PLATO BIOMARKER SUBSTUDY
Authors: Lars Wallentin, Annika E. Michelsen, Pål Aukrust, Richard Becker, Maria Bertilsson, Andrzej Budaj, Jan Cornel, Anders Himmelmann, Steen Husted, Agneta Siegbahn, Robert Storey, Frederic Kontny, Thor Ueland
Journal: Journal of the American College of Cardiology (2015)
P16 An Investigation into ‘Do Not Resuscitate Orders’ in Adults Admitted For Pneumonia
Authors: E Cant, MA Woodhead
Journal: Thorax (2012)

The NHS Outcomes framework classes respiratory deaths in those aged under 75 as potentially avoidable. In practise the level of care available is often limited in those who are unlikely to benefit from invasive interventions which may limit death ‘avoidability’. We sought the frequency of such limitations by investigation of the use of ‘Do not actively resuscitate’ (DNAR) orders in adults with pneumonia. Adult admissions for pneumonia (ICD10 J12-J18) to one NHS Trust between 01/01/2012 and 31/05/2012 were retrospectively identified. Case details were gleaned from the case records. 293 cases were found of which 81 (28%) died. After exclusions (no radiographic pneumonia (12), no radiograph within 24 hours (1) and no radiograph (1)), 67 deaths remained. From these, 20 case notes were obtained and compared with the 40 subsequent surviving admissions. DNAR orders were present in 18 (30%) cases. 11 DNAR orders were recorded within 48 hours of admission, 2 within the next 48 hours and 5 in the following 5 days. They were more frequent in those who died (13/20 – 65%) than those that survived (5/40 – 12.5%; p&lt;0.001). There was a non-significant trend for DNAR to be less frequent in those ≤75 (6/31 – 33%) than those aged &gt;75 (12/29 – 67%; p=0.091) and they were more frequent in those admitted from nursing homes (5/7 – 71.4%) than from their own home (9/49 – 18.4%; p&lt;0.001). 11/60 (18.3%) were admitted to ICU but patients with DNAR were no more or less likely to be so managed (5/18 – 27.8% cf 6/42 – 14.3%; p=0.279). There was a trend for DNAR to have been recorded more often in the more severely ill. Rates by CURB65 score were 0 – 1/5 (20%), 1 – 2/17 (11.8%), 2 – 3/15 (20%), 3 – 8/17 (47.1%), 4 – 3/5 (60%), 5 – 1/1 (100%); p=0.063. The high frequency of DNAR orders suggests that pneumonia deaths may not be as preventable as might be considered at first sight. This may be especially true for those aged &gt;75. In any assessment of the predictability of death the use of DNAR orders should be considered.
SAT0111 Short Term Results of Total Elbow Arthroplasty Using Novel Linked Type Prosthesis in Rheumatoid Arthritis Patients
Authors: A. Nampei, Y. Nagayama
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Total elbow arthroplasty (TEA) is a recognized procedure for painful destructed elbow joint of rheumatoid arthritis (RA) patients. The Discovery elbow system is one of the latest linked type elbow prosthesis, modified from Coonrad-Morrey elbow system which is the most popular linked type prosthesis in the world. This system was designed to decrease polyethylene-bushing wear, improve anatomic and slimmed stem design, and simplify the bearing exchange. We retrospectively investigated the short term results of Discovery TEA for RA patients <h3>Objectives</h3> To investigate the short term results of n TEA using the Discovery elbow system for RA patients. <h3>Methods</h3> A total of 12 TEA using the Discovery elbow system, which had been undergone since September 2010, was included in this retrospective study. All patients were RA and female, with a mean age of 63 years, and with mean disease duration of 22 years. Mean follow-up period were 19 months. In preoperative radiographic findings, 9 elbow were Larsen grade 4 and 3 elbow were grade 5. Mayo elbow performance score (MEPS), range of motion, radiographic findings, and complication were investigated. <h3>Results</h3> The mean MEPS was improved from 36 (15-65) preoperatively to 93 (85-100) at final follow-up. All patients were pain-free at final follow-up. Elbow flexion angle was significantly improved from 112 to 139, while elbow extension angle was not improved significantly (from -35 to -29). There was no infection and no implant loosening. Complications included one intraoperative lateral condyle fracture, 4 postoperative condyle fracture (medial 3, lateral 1), one delayed wound healing, and one ulnar nerve neuropathy. <h3>Conclusions</h3> Discovery elbow system was useful surgical device for TEA in RA patients with satisfactory short-term clinical and radiographic outcomes. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4217
Pencil-Core Granuloma
Authors: Takafumi Taguchi, Yoshio Terada
Journal: New England Journal of Medicine (2012)

A 75-year-old woman presented with a bluish discoloration, measuring 1 cm in diameter, on the dorsal surface of the terminal phalanx of her right index finger. The patient reported that she had stuck the tip of her finger with a lead pencil 50 years earlier.
Use of novel intracoronary technology to investigate the effect of cold air inhalation during exercise on coronary microvascular resistance and blood flow in coronary artery disease: a cross-sectional study
Authors: Rupert Williams, Kaleab Asrress, Matthew Lumley, Satpal Arri, Tiffany Patterson, Howard Ellis, Vasiliki Manou-Stathopoulou, Zeeshan Khawaja, Natalia Briceno, Konstantinos Moschonas, Brian Clapp, Divaka Perera, Sven Plein, Michael Marber, Simon Redwood
Journal: The Lancet (2016)
Automatic optimal filament segmentation with sub-pixel accuracy using generalized linear models and B-spline level-sets
Authors: Xun Xiao, Veikko F. Geyer, Hugo Bowne-Anderson, Jonathon Howard, Ivo F. Sbalzarini
Journal: Medical Image Analysis (2016)

Biological filaments, such as actin filaments, microtubules, and cilia, are often imaged using different light-microscopy techniques. Reconstructing the filament curve from the acquired images constitutes the filament segmentation problem. Since filaments have lower dimensionality than the image itself, there is an inherent trade-off between tracing the filament with sub-pixel accuracy and avoiding noise artifacts. Here, we present a globally optimal filament segmentation method based on B-spline vector level-sets and a generalized linear model for the pixel intensity statistics. We show that the resulting optimization problem is convex and can hence be solved with global optimality. We introduce a simple and efficient algorithm to compute such optimal filament segmentations, and provide an open-source implementation as an ImageJ/Fiji plugin. We further derive an information-theoretic lower bound on the filament segmentation error, quantifying how well an algorithm could possibly do given the information in the image. We show that our algorithm asymptotically reaches this bound in the spline coefficients. We validate our method in comprehensive benchmarks, compare with other methods, and show applications from fluorescence, phase-contrast, and dark-field microscopy.
P637 HBsAg AND ANTI-HCV SCREENING IN SENESCENT HOSPITALIZED PATIENTS OF A GERMAN TERTIARY REFERRAL CENTRE
Authors: J. Kant, J. Kratzsch, M. Maier, U.G. Liebert, J. Thiery, S. Böhm, T. Berg, J. Wiegand
Journal: Journal of Hepatology (2014)
A NOVEL METHOD TO QUANTIFY THE INSTANTANEOUS MITRAL REGURGITANT RATE
Authors: Seth Uretsky, Azhar Supariwala, Srinivasa Gurram, Eric Bader, Sri Lakshmi Kala Bonda, Naganath Thota, Randy Cohen, Seema Reddy Manchireddy, Edgar Argulian, Farooq A. Chaudhry, Steven D. Wolff
Journal: Journal of the American College of Cardiology (2013)
A RADIATION- AND CONTRAST-SPARING PROTOCOL FOR CORONARY COMPUTED TOMOGRAPHY ANGIOGRAPHY: FIRST CLINICAL EXPERIENCE ON A LATEST-GENERATION 256-SLICE SCANNER
Authors: Dominik C. Benz, Christoph Gräni, Beatrice Hirt-Moch, Fran Mikulicic, Jan Vontobel, Tobias Fuchs, Julia Stehli, Olivier Clerc, Mathias Possner, Aju Pazhenkottil, Oliver Gaemperli, Ronny Buechel, Philipp Kaufmann
Journal: Journal of the American College of Cardiology (2016)
Abstract 4098: CXCR4 regulation of neuroblastoma migration and differentiation.
Authors: Yufei Shan, Cynthia M. Van Golen
Journal: Cancer Research (2013)

Abstract CXCR4 is a chemokine involved in the migration of numerous cell types, including hematopoietic cells, neuronal cells during differentiation, and metastatic tumor cells. CXCR4 has been implicated in the invasion of metastasis of multiple tumor types that metastasize to bone, including prostate carcinoma and breast carcinoma. However, in neuroblastoma, a pediatric tumor that frequently metastasizes to bone and causes osteolytic lesions, the role of CXCR4 has not been elucidated. Several studies have suggested multiple potential roles of CXCR4 activation and signaling in neuroblastoma progression, including proliferation, migration, and invasion. Our previous studies have shown that blocking the CXCR4 receptor using a neutralizing antibody reduces migration toward the CXCR4 ligand CXCL12. However, when CXCL12 is added to neuroblastoma cells, activating the receptor, rather than an increase in migration, neurite extension and differentiation occurs. Through subsequent studies, we have demonstrated that upon stimulation, CXCR4 interacts with the actin cytoskeleton, potentially through the adaptor protein drebrin. Furthermore, this interaction appears to be dependent upon Akt. Our current hypothesis is that at low levels of CXCL12, migration is induced; upon increased activation of the receptor, however, CXCR4 is internalized, reducing the amount of receptor on the cell surface, and the internalized receptor then interacts with actin to increase process extension. This enables the neuroblastoma cells to migrate toward favorable conditions, but once the cells have reached those conditions (such as high CXCL12 levels in bone), the cells to remain in that environment. Experiments are currently being performed to test this working hypothesis. Citation Format: Yufei Shan, Cynthia M. Van Golen. CXCR4 regulation of neuroblastoma migration and differentiation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4098. doi:10.1158/1538-7445.AM2013-4098
THU0056 Impaired beta cell signaling is present in non diabetic rheumatoid arthritis patients
Authors: I. Ferraz-Amaro, M. González-Gay, V. Hernández-Hernández, M. Arce-Franco, E. Delgado-Frías, M. Gantes, J. Muñiz, M. Dominguez-Luis, A. Herrera-García, J. Garcia-Dopico, L. Medina-Vega, A. Rodríguez-Vargas, F. Diaz-Gonzalez
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> It has been suggested that resistance to insulin action is a feature that accompanies rheumatoid arthritis (RA), a disease where chronic inflammation predominates and classical triggers for insulin resistance (IR) like obesity and diabetes are absents. However, data regarding characterization of RA features associated with this insulin resistance (IR) are lacking. The aim of this study was to investigate how sensitivity to insulin and markers of beta cell dysfunction (proinsulin processing metabolites) are expressed in RA. <h3>Methods</h3> 101 non-diabetic RA patients and 99 non-diabetic sex and age-matched controls were included in this study. Insulin sensitivity function through homeostatic model assessment (HOMA2), and beta cell secretion through insulin, split and intact proinsulin, and C-peptide were assessed in both groups. We performed multiple regression analysis to compare IR between groups and to explore the relation between RA features and IR. Data were adjusted for glucocorticoids intake and for IR classical risk factors. <h3>Results</h3> RA patients compared to controls show higher HOMA-IR (<i>log</i>HOMA-IR, beta coefficient, 0.40 [95% CI 0.20-0.59], p=0.00). When this data was adjusted for glucocorticoids intake, non-on corticosteroid patients maintained a higher IR index (beta coef. 0.14 [95% CI 0.05-0.24], p=0.00). Current prednisone treatment was not associated with higher IR in the patients' intragroup comparison (beta coef. 0.56 [1.13-1.19], p=0.22). Insulin processing signaling in RA patients showed impaired features via an elevated intact proinsulin levels (beta coef. 3.13 [0.81-5.44] pMol/L, p=0.03 for the comparison between patients and controls). Split proinsulin levels were also higher in RA patients (beta coef. 13.7 pmol/L [3.57-9.40], p=0.00) even adjusting for prednisone intake (beta coef. 2.66 pmol/L [95%CI 1.62-5.95] for non steroids RA patients when compared to controls). In multiple regression analysis, RA features (disease duration, rheumatoid factor, erythrocyte sedimentation rate, C-reactive protein, disease activity through HAQ and DAS28 scores, and current non-biologic disease modifying antirheumatic drug), when adjusted for sex, age and body mass index, were not associated with IR or insulin propeptides. <h3>Conclusions</h3> Beta cell signaling is impaired in non-diabetic and non-corticoids RA patients. <h3>Disclosure of Interest</h3> None Declared
Medical Care in Japan
Authors: Naoki Ikegami, John C. Campbell
Journal: New England Journal of Medicine (1995)

The Japanese health care system presents a tantalizing puzzle. On the positive side, universal health insurance has been achieved at relatively low cost and the health indexes of infant mortality and life expectancy at birth are among the best in the world. However, the system has been criticized for lack of good management, quality control, and attention to consumers.1 In this article we will discuss the link between the positive and negative aspects of the Japanese system by describing the use of a universal fee schedule to define much of the health care system. We will then describe current efforts . . .
407 ANTI-β1-INTEGRIN ANTIBODIES IMPROVE SURVIVAL OF ISOLATED HUMAN HEPATOCYTES SIGNIFICANTLY INCREASING ADHESION TO HEPATIC SINUSOIDAL ENDOTHELIUM UNDER FLOW AND ENGRAFTMENT IN MURINE LIVER FOLLOWING TRANSPLANTATION
Authors: D.C. Bartlett, V.S. Aldridge, A. Wilhelm, N. Davies, J. Youster, D.H. Adams, P.N. Newsome
Journal: Journal of Hepatology (2012)
Traitement endoscopique des tumeurs endocrines duodénales: résultats d'une étude rétrospective monocentrique
Authors: R Gincul, T Walter, V Lepilliez, V Hervieu, JC Saurin, B Napoléon, JC Souquet, M Adham, C Partensky, J Dumortier, C Lombard-Bohas, JA Chayvialle, JY Scoazec, T Ponchon
Journal: Endoscopy (2011)

Introduction: Les tumeurs endocrines (TE) duodéno-jéjunales proximales sont rares. En dehors de syndromes génétiques spécifiques, la découverte de ces tumeurs est souvent fortuite, lors d'une endoscopie digestive haute. Leur traitement dépend du grade histologique, et du statut ganglionnaire echoendoscopique ou par imagerie radiologique. En cas de volumineuse tumeur ou de présence de métastases ganglionnaires, un traitement chirurgical carcinologique doit être proposé. Dans le cas contraire, un traitement endoscopique peut être discuté. Le but de l'étude a été d'évaluer les résultats du traitement endoscopique des TE duodéno-jéjunales proximales.
A Rare Presentation of Myocardial Plasmacytoma Assessed by FDG PET/CT
Authors: Aaron Kian Ti Tong, Karen P. Mann, David M. Schuster, Xuexian Yan
Journal: Clinical Nuclear Medicine (2014)

We describe a rare case of myocardial plasmacytoma staged and followed up with FDG PET/CT. A 72-year-old man was incidentally identified with a right ventricular apical mass, which was pathologically confirmed to be a plasmacytoma. A pre-treatment FDG PET/CT scan subsequently showed lesions not only in the right ventricle but also in the bones and mediastinal lymph nodes, which led to the change in treatment plan. Post-therapy PET scan revealed good response. This case demonstrates the value of FDG PET/CT in accurately staging unusually presented plasmacytoma and in monitoring response to treatment.
SP0158 Assessment and management of SLE in a nurse led clinic
Authors: S.J. Brown
Journal: Annals of the Rheumatic Diseases (2013)

SLE (systemic lupus erythematosus or lupus) is a multi-system auto-immune connective tissue disease of unknown aetiology. Common presenting features include flitting arhralgias usually without erosive damage to joints, erythematous rashes, mouth ulcers, hair loss, headaches and depression. In many the disaese is mild and controllable, but in some the disease can be life threatening with multi organ involvement when the disaese is most active. Clearly assessing and managing an unpredictable disease such as SLE is challening to the specialist lupus team and problematic for the individual. Potentially impacting on all areas of everyday life, SLE is very difficult to live with and requires resilience and fortititude. It is this aspect of the disease trajectory that is the most important for the lupus specialist nurse who provides support, advice, education and counselling to lupus patients and their families as needed. Lupus specialist nurses assess for evidence of disease activity and formulate treatment plans in agreement with the specialist team and patient. By fully involving the patient in their care, the specialist nurse is available to provide information about potential risks, alerting the individual to the red flags that need immediate action and guide the patients in the development of self management skills to improve outcomes. Key messages from this session include: –To gain an understanding of the important role of the lupus nurse specialist –To recognise the importance of easy access to specialist lupus teams when the disease is most active –To understand the importance of empowering the patient to gain control of their disease activity and to improve outcome. <h3>Disclosure of Interest</h3> None Declared
Asystole During Dipyridamole Infusion in Patients Without Coronary Artery Disease or Beta-Blocker Therapy
Authors: MARTIN FROSSARD, KONRAD WEISS, HEINZ GÖSSINGER, ANDREA ZEINER, THOMAS LEITHA
Journal: Clinical Nuclear Medicine (1997)

The authors report two patients without coronary artery disease who experienced asystole during the IV infusion of dipyridamole on routine Tl-201 myocardial perfusion imaging and review the literature for possible explanations of this rare side effect. Until now, this side effect was only reported in patients with coronary artery disease or beta-blocker therapy. Yet, the cases lacked both concomitant factors and autonomic dysregulation is suggested as a cause for asystole
THE ROLE OF SYSTEMIC INFLAMMATION IN PAROXYSMAL AND CHRONIC ATRIAL FIBRILLATION
Authors: Gerasimos Siasos, Savvas Mazaris, Konstantinos Zisimos, Evangelos Oikonomou, Eleni Kokkou, Theodosia Konsola, Konstantinos Mourouzis, Manolis Vavuranakis, Theodoros Zografos, Marina Zaromitidou, George Lazaros, Christine Chrysohoou, Athanasios Papavassiliou, Christodoulos I Stefanadis, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2015)