tbuckley/cabot-search huggingface dataset:
Validation and Modification of a Prediction Model for Acute Cardiac Events in Patients With Breast Cancer Treated With Radiotherapy Based on Three-Dimensional Dose Distributions to Cardiac Substructures
Authors: Veerle A.B. van den Bogaard, Bastiaan D.P. Ta, Arjen van der Schaaf, Angelique B. Bouma, Astrid M.H. Middag, Enja J. Bantema-Joppe, Lisanne V. van Dijk, Femke B.J. van Dijk-Peters, Laurens A.W. Marteijn, Gertruida H. de Bock, Johannes G.M. Burgerhof, Jourik A. Gietema, Johannes A. Langendijk, John H. Maduro, Anne P.G Crijns
Journal: Journal of Clinical Oncology (2017)

Purpose A relationship between mean heart dose (MHD) and acute coronary event (ACE) rate was reported in a study of patients with breast cancer (BC). The main objective of our cohort study was to validate this relationship and investigate if other dose-distribution parameters are better predictors for ACEs than MHD. Patients and Methods The cohort consisted of 910 consecutive female patients with BC treated with radiotherapy (RT) after breast-conserving surgery. The primary end point was cumulative incidence of ACEs within 9 years of follow-up. Both MHD and various dose-distribution parameters of the cardiac substructures were collected from three-dimensional computed tomography planning data. Results The median MHD was 2.37 Gy (range, 0.51 to 15.25 Gy). The median follow-up time was 7.6 years (range, 0.1 to 10.1 years), during which 30 patients experienced an ACE. The cumulative incidence of ACE increased by 16.5% per Gy (95% CI, 0.6 to 35.0; P = .042). Analysis showed that the volume of the left ventricle receiving 5 Gy (LV-V5) was the most important prognostic dose-volume parameter. The most optimal multivariable normal tissue complication probability model for ACEs consisted of LV-V5, age, and weighted ACE risk score per patient (c-statistic, 0.83; 95% CI, 0.75 to 0.91). Conclusion A significant dose-effect relationship was found for ACEs within 9 years after RT. Using MHD, the relative increase per Gy was similar to that reported in the previous study. In addition, LV-V5 seemed to be a better predictor for ACEs than MHD. This study confirms the importance of reducing exposure of the heart to radiation to avoid excess risk of ACEs after radiotherapy for BC.
Clinical Observation on the Efficacy of All-Trans Retinoic Acid (ATRA) Combined with Arsenic Trioxide (As2O3) in Newly Diagnosed Acute Promyelocytic Leukemia (APL).
Authors: Y.F. Liu, Z.X. Shen, J. Hu, Y.M. Zhu, J.M. Li, J.H. You, Y. Shen, Z.Z. Shi, S.J. Chen, Z. Chen, Z.Y. Wang
Journal: Blood (2004)
Rapamycin-mediated mTOR inhibition uncouples HIV-1 latency reversal from cytokine-associated toxicity
Authors: Alyssa R. Martin, Ross A. Pollack, Adam Capoferri, Richard F. Ambinder, Christine M. Durand, Robert F. Siliciano
Journal: Journal of Clinical Investigation (2017)

Current strategies for HIV-1 eradication require the reactivation of latent HIV-1 in resting CD4+ T cells (rCD4s). Global T cell activation is a well-characterized means of inducing HIV-1 transcription, but is considered too toxic for clinical applications. Here, we have explored a strategy that involves a combination of immune activation and the immunosuppressive mTOR inhibitor rapamycin. In purified rCD4s from HIV-1-infected individuals on antiretroviral therapy, rapamycin treatment downregulated markers of toxicity, including proinflammatory cytokine release and cellular proliferation that were induced after potent T cell activation using αCD3/αCD28 antibodies. Using an ex vivo assay for HIV-1 mRNA, we demonstrated that despite this immunomodulatory effect, rapamycin did not affect HIV-1 gene expression induced by T cell activation in these rCD4s. In contrast, treating activated rCD4s with the immunosuppressant cyclosporin, a calcineurin inhibitor, robustly inhibited HIV-1 reactivation. Importantly, rapamycin treatment did not impair cytotoxic T lymphocyte (CTL) recognition and killing of infected cells. These findings raise the possibility of using rapamycin in conjunction with T cell-activating agents in HIV-1 cure strategies.
Non T-Depleted Bone Marrow Transplantation From Haploidentical Related Donor in Hematological Malignancies.
Authors: Stella Santarone, Gottardo De Angelis, Erminia Di Bartolomeo, Pasqua Bavaro, Mauro Montanari, Pietro Leoni, Raffaella Cerretti, Paolo Di Bartolomeo, William Arcese
Journal: Blood (2009)
Distribution of cardiac myosin isozymes in cardiomyopathy. Immunohistochemical and gene analysis.
Authors: Yoshi Yazaki, Hidetsugu Tsuchimochi, Masahiko Kurabayashi, Masatoshi Kawana, Shin-Ichi Kimata
Journal: Circulation (1987)

We characterized cardiac myosin isoforms by immunohistochemical approaches using monoclonal antibodies and demonstrated the existence of a distinctive type of cardiac myosin heavy chain which predominates in the fetal stage but is depressed during postnatal development. Furthermore, we showed that this type of cardiac myosin heavy chain was markedly expressed in patients with dilated cardiomyopathy. The results suggested that the pathologic process involved in dilated cardiomyopathy affects myocardial differentiation by the inhibition of the myosin gene switching that normally occurs during muscle maturation. However, we could not find any polymorphism in myosin gene in our population sample of dilated cardiomyopathy. The pathophysiological role of fetal type cardiac myosin expression in dilated cardiomyopathy will be clarified by the characterization of the myosin near future.
A Multi-Center Phase I/II Trial of Carfilzomib and Pomalidomide with Dexamethasone (Car-Pom-d) in Patients with Relapsed/Refractory Multiple Myeloma
Authors: Jatin J. Shah, Edward A. Stadtmauer, Rafat Abonour, Adam D Cohen, William I. Bensinger, Cristina Gasparetto, Jonathan L. Kaufman, Suzanne Lentzsch, Dan T. Vogl, Robert Z. Orlowski, Erica L. Kim, Marti B. McKinley, Brian G M Durie
Journal: Blood (2012)
Detailed Echocardiographic Phenotyping in Breast Cancer Patients
Authors: Hari K. Narayan, Brian Finkelman, Benjamin French, Theodore Plappert, David Hyman, Amanda M. Smith, Kenneth B. Margulies, Bonnie Ky
Journal: Circulation (2017)

Cardiovascular disease in patients with breast cancer is of growing concern. The longitudinal effects of commonly used therapies, including doxorubicin and trastuzumab, on cardiac remodeling and function remain unknown in this population. We aimed to define the changes in echocardiographic parameters of structure, function, and ventricular-arterial coupling, and their associations with left ventricular ejection fraction (LVEF) and heart failure symptoms.
Evaluation of TNF Superfamily Molecules Release by Neutrophils and B Leukemic Cells of Patients with Chronic B – Cell Lymphocytic Leukemia
Authors: Jolanta Sawicka-Powierza, Ewa Jablonska, Janusz Kloczko, Jaroslaw Piszcz, Marzena Garley, Wioletta Ratajczak-Wrona
Journal: Blood (2010)
Conventional Chemotherapy Followed by Consolidation with Autologous Hematopoietic TransplantationVs Chemotherapy Alone in HIV+ Patients with Large B Cell Lymphoma (LBCL) in First Complete Remission (CR). A Retrospective Analysis On Behalf of the EBMT Lymphoma Working Party and the GESIDA/PETHEMA Registry of HIV+ Patients with Non-Hodgkin's Lymphoma (NHL).
Authors: Pascual Balsalobre, Juan Berenguer, Pilar Miralles, David Serrano, Josep-Maria Ribera, Carmen Canals, Marisa Montes, Mariagrazia Michieli, Eulalia Valencia, Anne Rosselet, Francisco Rodríguez-Arrondo, Philippe Genet, Maria J Galindo, Augustin Ferrant, Vicente Pintado, Jose M Bellon, Anna Sureda, Jose L. Diez-Martin
Journal: Blood (2009)
Underestimation of pediatric asthma in Belarus, Poland, and Ukraine
Authors: Jan Zejda, Grzegorz Brozek, Andrei Shpakou, Olga Fedortsiv, Joshua Lawson, Donna Rennie
Journal: European Respiratory Journal (2014)

Introduction : There is a relatively low prevalence of pediatric asthma in Eastern Europe with some evidence of a diagnostic labeling effect where ”spastic bronchitis“ is used as a surrogate diagnosis for asthma.   Objective : To investigate the role of diagnostic labelling in the regional variation of childhood asthma prevalence in Eastern Europe.   Methods:  A population-based lung health survey using ISAAC questions was completed in Belarus (BR: n= 3404), Ukraine (UE: n = 3846), and Poland (PL: n = 3385). Surveys were completed by parents of 7-12 year olds.   Results:  Ever diagnosed asthma prevalence differed between the three regions: BR=1.47%, UE=2.08%, PL = 4.11% (p=0.0001). The prevalence of spastic bronchitis followed the opposite pattern: BR=7.46%, UE=6.79%, PL=2.92% (p=0.0001). The mean age of asthma diagnosis also differed by country [BR=5.1+/-2,7 years, UE=4.1+/-2.6 years, and PL=3.5+/-2.3 years (p=0.001)]. Trends in regional variation of asthma and spastic bronchitis prevalence stratified by age group (7-8 years, 9-10 years, and 11-12 years) matched those seen in the overall population (p=0.03). Having either asthma or spastic bronchitis occurred in 8.02% in BR, 7.77% in UE and 5.67% in PL (p=0.0002). Few children without either diagnosis reported current (last 12 months) attacks of breathlessness together with chest wheeze outside infections (BR: 1.12%, UE: 3.10%, PL: 1.57%; p=0.0001).   Conclusions:  Pediatric asthma prevalence was underestimated, most likely due to nozologic preferences. Regional differences could result from a delay in the final diagnosis of asthma. A low prevalence of symptoms in children without either diagnosis support a true asthma prevalence reflected by a composed rate of both diseases.
Eating disorders are more prevalent than expected in women during midlife, study finds
Authors: Ingrid Torjesen
Journal: BMJ (2017)

The prevalence of eating disorders in women in midlife is higher than expected, a study published in BMC Medicine has found, as 3.6% of women in their 40s and 50s reported having experienced an eating disorder in the past 12 months.1

Eating disorders are often associated with adolescence and early adulthood, but the study, which assessed the prevalence of eating disorders in the fifth and sixth decades of life, found that they were surprisingly common and frequently went untreated.

The study included 5320 UK women, of whom around 15.3% (95% confidence interval 13.5% to 17.4%) reported having had an eating disorder at some point in life, and less than 30% of those said that they had sought help or received treatment for it.

Nadia Micali, lead author, …
Management of Pregnancy in Patients With Complex Congenital Heart Disease: A Scientific Statement for Healthcare Professionals From the American Heart Association
Authors: Mary M. Canobbio, Carole A. Warnes, Jamil Aboulhosn, Heidi M. Connolly, Amber Khanna, Brian J. Koos, Seema Mital, Carl Rose, Candice Silversides, Karen Stout
Journal: Circulation (2017)

Today, most female children born with congenital heart disease will reach childbearing age. For many women with complex congenital heart disease, carrying a pregnancy carries a moderate to high risk for both the mother and her fetus. Many such women, however, do not have access to adult congenital heart disease tertiary centers with experienced reproductive programs. Therefore, it is important that all practitioners who will be managing these women have current information not only on preconception counseling and diagnostic evaluation to determine maternal and fetal risk but also on how to manage them once they are pregnant and when to refer them to a regional center with expertise in pregnancy management.
Autologous Stem Cell Transplantation In Mantle Cell Lymphoma: The Experience of the French SFGM-TC Group
Authors: Cyrille Touzeau, Richard Delarue, Christophe Leux, Murielle Roussel, Krimo Bouabdallah, Olivier Tournilhac, Guillaume Cartron, Laetitia Compain, Emmanuel Gyan, Catherine Thieblemont, Olivier Casasnovas, Marie-Pierre Moles, Didier Blaise, Morschhauser Franck, Pierre Peterlin, Mohamad Mohty, Noel Milpied, Steven Le Gouill
Journal: Blood (2010)
A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells
Authors: Sherly Mardiana, Liza B. John, Melissa A. Henderson, Clare Y. Slaney, Bianca von Scheidt, Lauren Giuffrida, Alexander J. Davenport, Joseph A. Trapani, Paul J. Neeson, Sherene Loi, Nicole M. Haynes, Michael H. Kershaw, Paul A. Beavis, Phillip K. Darcy
Journal: Cancer Research (2017)

Abstract Adoptive immunotherapy utilizing chimeric antigen receptor (CAR) T cells has demonstrated high success rates in hematologic cancers, but results against solid malignancies have been limited to date, due in part to the immunosuppressive tumor microenvironment. Activation of the 4-1BB (CD137) pathway using an agonistic α-4-1BB antibody is known to provide strong costimulatory signals for augmenting and diversifying T-cell responses. We therefore hypothesized that a combination of α-4-1BB and CAR T-cell therapy would result in improved antitumor responses. Using a human-Her2 self-antigen mouse model, we report here that α-4-1BB significantly enhanced CAR T-cell efficacy directed against the Her2 antigen in two different established solid tumor settings. Treatment also increased the expression of IFNγ and the proliferation marker Ki67 in tumor-infiltrating CAR T cells when combined with α-4-1BB. Strikingly, α-4-1BB significantly reduced host immunosuppressive cells at the tumor site, including regulatory T cells and myeloid-derived suppressor cells, correlating with an increased therapeutic response. We conclude that α-4-1BB has a multifunctional role for enhancing CAR T-cell responses and that this combination therapy has high translational potential, given current phase I/II clinical trials with α-4-1BB against various types of cancer. Cancer Res; 77(6); 1296–309. ©2017 AACR.
Spleen tyrosine kinase inhibition blocks airway constriction and protects from Th2‐induced airway inflammation and remodeling
Authors: C. Tabeling, J. Herbert, A. C. Hocke, D. J. Lamb, S. L. Wollin, K. J. Erb, E. Boiarina, H. Movassagh, J. Scheffel, J. M. Doehn, S. Hippenstiel, M. Maurer, A. S. Gounni, W. M. Kuebler, N. Suttorp, M. Witzenrath
Journal: Allergy (2016)

Spleen tyrosine kinase (Syk) is an intracellular nonreceptor tyrosine kinase, which has been implicated as central immune modulator promoting allergic airway inflammation. Syk inhibition has been proposed as a new therapeutic approach in asthma. However, the direct effects of Syk inhibition on airway constriction independent of allergen sensitization remain elusive.Spectral confocal microscopy of human and murine lung tissue was performed to localize Syk expression. The effects of prophylactic or therapeutic Syk inhibition on allergic airway inflammation, hyperresponsiveness, and airway remodeling were analyzed in allergen-sensitized and airway-challenged mice. The effects of Syk inhibitors BAY 61-3606 or BI 1002494 on airway function were investigated in isolated lungs of wild-type, PKCα-deficient, mast cell-deficient, or eNOS-deficient mice.Spleen tyrosine kinase expression was found in human and murine airway smooth muscle cells. Syk inhibition reduced allergic airway inflammation, airway hyperresponsiveness, and pulmonary collagen deposition. In naïve mice, Syk inhibition diminished airway responsiveness independently of mast cells, or PKCα or eNOS expression and rapidly reversed established bronchoconstriction independently of NO. Simultaneous inhibition of Syk and PKC revealed additive dilatory effects, whereas combined inhibition of Syk and rho kinase or Syk and p38 MAPK did not cause additive bronchodilation.Spleen tyrosine kinase inhibition directly attenuates airway smooth muscle cell contraction independent of its protective immunomodulatory effects on allergic airway inflammation, hyperresponsiveness, and airway remodeling. Syk mediates bronchoconstriction in a NO-independent manner, presumably via rho kinase and p38 MAPK, and Syk inhibition might present a promising therapeutic approach in chronic asthma as well as acute asthma attacks.
Association of Extension of Cervical Cord Lesion and Area Postrema Syndrome With Neuromyelitis Optica Spectrum Disorder
Authors: Divyanshu Dubey, Sean J. Pittock, Karl N. Krecke, Eoin P. Flanagan
Journal: JAMA Neurology (2017)

This study evaluates whether longitudinally extensive cervical cord lesions extending to or accompanied by area postrema/dorsal medulla lesions on magnetic resonance imaging are specific for neuromyelitis optica spectrum disorders.
Randomized Trial on GvHD Prophylaxis with or without Anti-T-Cell Globulin ATG-Fresenius (ATG-F) In Allogeneic Hematopoietic Cell Transplantation From Matched Unrelated Donors: Final Results and Analysis of Prognostic Factors
Authors: Jurgen Finke, Claudia Schmoor, Wolfgang Andreas Bethge, Hellmut Ottinger, Matthias Stelljes, Axel R. Zander, Liisa Volin, Dominik Heim, Rainer Schwerdtfeger, Hartmut Bertz, Olga Grishina, Gérard Socié
Journal: Blood (2010)
Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable
Authors: Irma Tindemans, Melanie Lukkes, Marjolein J.W. de Bruijn, Bobby W.S. Li, Menno van Nimwegen, Derk Amsen, Alex KleinJan, Rudi W. Hendriks
Journal: Journal of Allergy and Clinical Immunology (2017)
Toward Precision Medicine of Symptom Control in Asthma
Authors: Jose L. Gomez, Naftali Kaminski
Journal: American Journal of Respiratory and Critical Care Medicine (2017)

Peripheral Artery Disease in Patients with Chronic Obstructive Pulmonary DiseaseChronic obstructive pulmonary disease (COPD) is a highly prevalent chronic pulmonary disease defined by persistent airflow limitation, but is frequently associated with extrapulmonary manifestations and comorbidities.Because of common risk factors such as smoking and aging, COPD often coexists with cardiovascular diseases that have an important impact on prognosis.Atherosclerosis is the main driver in the pathogenesis of vascular diseases and can occur in various arterial vascular beds.In smokers, a strong association has been demonstrated between COPD and coronary artery disease, causing ischemic heart disease (encompassing angina pectoris and myocardial
Prognostic Utility of the European LeukemiaNet (ELN) Genetic-Risk Classification in Adults with De Novo Acute Myeloid Leukemia (AML): A Study of 1,550 Patients (Pts)
Authors: Krzysztof Mrózek, Guido Marcucci, Kati Maharry, Deedra Nicolet, Heiko Becker, Susan P. Whitman, Klaus H. Metzeler, Sebastian Schwind, Yue-Zhong Wu, Jessica Kohlschmidt, Mark J. Pettenati, Prasad R. K. Koduru, Nyla A. Heerema, Annemarie W. Block, Shivanand R. Patil, Maria R. Baer, Jonathan E. Kolitz, Joseph O. Moore, Andrew J. Carroll, Richard A. Larson, Clara D. Bloomfield
Journal: Blood (2011)
Pericarditis in Children : Symposium III Pericarditis
Authors: Kensuke Harada
Journal: Circulation (1978)

1. The clinical study of 24 patients with pericarditis has been presented. 2. In this series the patients were predominantly female. 3. Collagen disease was the most common cause followed by idiopathic pericarditis. Rheumatic and tuberculous pericarditis were rare. 4. Rheumatic anc tuberculous pericarditis were rare. 5. Three cases of constrictive pericarditis were presented in this series. Two were with atrial septal defect and one was tuberculous pericarditis. 6. Recognition of the right ventricular dip and platear curve by cardiac catheterization is necessary for the diagnosis of constrictive pericarditis. 7. In constrictive pericarditis right ventricular dip and platear curve remained longer after the operation of pericardiectomy. 8. THe typical physical findings were fever, cardiomegaly, hepatomegaly and tachycardia. 9. Right side cardiac faulure was more common than left side failure. 10. Friction rub, distant cardiac sound and paradoxical pulse were less common than it has been thought. No specific laboratory finding was present. 12. None of the cases revealed elevated virus titer. 13. Most of the patients revealed enlarged cardiac silhouette in chest X-ray. 14. The electrocardiographic changes were low voltage, ST segment elevation and T wave abnormality. 15. The ST segment elevation was seen in all standard leads, especially in aVF and from V2 to V6. 16. The abonormal T wave vector oriented to superiorly posteriorly and to right or left. 17. The presence of abonormal T wave suggests myocardial involvement. 18. In some cases T wave abonormality persists after the echocardiographic disappearance of pericardial fluid. 19. Arrhythmia was rare except constrictive pericarditis.
Fluctuation of Cystatin C Concentration during Deferasirox Treatment in Thalassemic Patients May Reflect Hemodynamic Changes
Authors: Ioannis Papassotiriou, Antonios Kattamis, Eugenia Hantzi, Polyxeni Delaporta, Athanassia Sergounioti, Alexandra Margeli, Vassilios Ladis
Journal: Blood (2008)
A review of the physiological and psychological health and wellbeing of naval service personnel and the modalities used for monitoring
Authors: Cliodhna Sargent, Cormac Gebruers, Jim O’Mahony
Journal: Military Medical Research (2017)

Naval cohorts rely heavily on personnel to ensure the efficient running of naval organisations. As such, the wellbeing of personnel is essential. In an occupational setting, naval service personnel experience a variety of physiological and psychological stressors. Most naval services arrange annual physical fitness and body composition tests to ensure the physical readiness of personnel. However, these tests only evaluate a small amount of physiological capabilities. Components such as aerobic and strength capabilities are assessed, however, other components of physical fitness such as speed, agility, anaerobic capacity and flexibility are not. In addition to the physical capabilities, personnel are impacted by fatigue, nutrition and psychological stressors such as copping in stressful situations or dealing with time away from family and friends. This review will discuss the physiological and psychological factors that affect personnel's wellbeing. In addition to this, it will also evaluate the methods that are used to assess both physiological and psychological wellbeing.
Prognostic Impact of Clinical and Molecular Markers in Normal Karyotype AML-Results from the AMLCG 2000 Trial.
Authors: Friederike Schneider, Eva Hoster, Marietta Rottenkolber, Stephanie Schneider, Annika Dufour, Tobias Benthaus, Gudrun Mellert, Evelyn Zellmeier, Stefan K. Bohlander, Michael Unterhalt, Michaela Feuring-Buske, Christian Buske, Jan Braess, Achim Heinecke, Wolfgang E. Berdel, Thomas Buechner, Wolfgang Hiddemann, Karsten Spiekermann
Journal: Blood (2007)
The Combination of Bortezomib, Doxorubicin, and Dexamethasone (PAD) Is an Effective Regimen for High Risk, Newly Diagnosed, Patients with Multiple Myeloma, Reduces Bone Resorption and Normalizes Angiopoietin-1 to Angiopoietin-2 Ratio.
Authors: Evangelos Terpos, Sosana Delimpasi, Konstantinos Anargyrou, Ioannis Baltathakis, Efstathios Kastritis, Anna Christoforidou, Konstantinos Tsionos, Konstantinos Tsatalas, Emmanuel Nikiforakis, Meletios A. Dimopoulos, Nikolaos Harhalakis
Journal: Blood (2007)