tbuckley/cabot-search huggingface dataset:
Studies on the Occurrence of Spontaneous Hepatomas in Mice of Strains C3H and CBA&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Howard B. Andervont
Journal: JNCI Journal of the National Cancer Institute (1950)

Studies on the Occurrence of Spontaneous Hepatomas in Mice of Strains C3H and CBA Get access Howard B. Andervont Howard B. Andervont National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 3, December 1950, Pages 581–592, https://doi.org/10.1093/jnci/11.3.581 Published: 01 December 1950 Article history Received: 26 October 1950 Published: 01 December 1950
A Serological Marker of Collagen Type III Crosslinking Correlates Strongly with Severity of Liver Disease
Authors: M.A. Karsdal, M.J. Nielsen, M. Thiele, F. Genovese, B.S. Madsen, J.F. Hansen, L. Møller, S. Detlefsen, O.S. de Muckadell, D.J. Leeming, A. Krag
Journal: Journal of Hepatology (2016)
Lipid- and polyion complex-based micelles as agonist platforms for TNFR superfamily receptors
Authors: Ryan N. Gilbreth, Shabazz Novarra, Leslie Wetzel, Stelios Florinas, Horacio Cabral, Kazunori Kataoka, Jonathan Rios-Doria, Ronald J. Christie, Manuel Baca
Journal: Journal of Controlled Release (2016)
Weight Loss for Urinary Incontinence in Overweight and Obese Women
Authors: Zekeriya Ulger, Mustafa Cankurtaran, Servet Arýogul
Journal: New England Journal of Medicine (2009)

TO THE EDITOR:  Subak et al. (Jan. 29 issue)  1   report that weight loss among overweight and obese women with urinary incontinence decreased the frequency of incontinence. The mechanism is unclear. It is commonly assumed that reduced intraabdominal pressure is responsible. However, dietary changes independent of weight loss may be overlooked. Sodium intake is particularly important. We estimate that the sodium intake of participants at baseline was 3840 mg per day (167 mmol), on the basis of a sodium intake, adjusted for sex and age, of 1.63 mg per kilocalorie,  2   multiplied by the energy requirement for low-activity women. The energy requirement . . .
Childhood epidermolysis bullosa acquisita during squaric acid dibutyl ester immunotherapy for alopecia areata
Authors: L. Guerra, V. Pacifico, V. Calabresi, N. De Luca, D. Castiglia, C. Angelo, G. Zambruno, G. Di Zenzo
Journal: British Journal of Dermatology (2016)

Epidermolysis bullosa acquisita (EBA) is a rare acquired subepidermal blistering disease associated with autoantibodies against type VII collagen. Although EBA manifests more frequently in adults, it can occur in childhood. We describe a 6-year-old boy who developed the inflammatory variant of EBA shortly after initiation of immunotherapy with squaric acid dibutyl ester (SADBE) for scalp alopecia areata. The disease rapidly regressed following SADBE discontinuation and starting combined steroid and dapsone therapy, and never recurred after treatment tapering and withdrawal. The association of EBA with other autoimmune diseases is common, but EBA occurring during alopecia areata has not been described previously. The development of EBA during SADBE treatment is also notable: the clinical history and therapeutic response in our patient point to a possible role of SADBE in EBA onset.
AB0429 The Role of TH9 Lymphocytes in Rheumatoid Arthritis
Authors: R. Talotta, A.M. Berzi, F. Atzeni, D. Dell'Acqua, D. Trabattoni, P. Sarzi-Puttini
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Th9 cells are IL-9-secreting Th lymphocytes that are involved in the immunological responses underlying parasitic infections and allergic diseases. In the case of autoimmune diseases, Th9 cells seem to be involved in the pathogenesis of experimental autoimmune encephalomyelitis. No study has yet evaluated the effects of Th9 responses in rheumatic diseases such as rheumatoid arthritis (RA). <h3>Objectives</h3> The aim of this study was determine the prevalence of Th9 lymphocytes in RA patients and identify their possible association with the discontinuation of biological treatment with infliximab (IFX). <h3>Methods</h3> We enrolled 55 consecutive RA outpatients: 15 not receiving any immunosuppressive drug; 20 responders to IFX treatment; and 20 who had discontinued IFX because of adverse events or inefficacy and were being treated with other biological agents (ABA, TCZ, ETN or CTZ) and traditional immunosuppressive drugs. The matched control group consisted of 10 healthy subjects. After giving their informed consent, the subjects underwent blood sampling for the isolation of peripheral blood mononuclear cells (PBMCs). The PBMCs were cultured with/without IFX 50 mg/L for 18 hours, and the percentage of Th9 cells was assessed by means of flow cytometry. Th9 lymphocytes were identified as IFNγ<sup>-</sup>, IL4<sup>-</sup>, IL17<sup>-</sup>, IL9-secreting CD4+ T cells. <h3>Results</h3> Cytometric analysis revealed no significant decrease in the percentage of Th9 cells after IFX exposure in any of the groups, but there were significantly fewer cells in the healthy controls than the RA patients both before and after the IFX stimulation assay (Fig.1). The higher frequency of Th9 cells in the patients was not associated with higher levels of anti-nucleus autoantibodies or other auto-antibody subsets, or with a higher likelihood of experiencing an adverse event or lack of efficacy on IFX treatment. <h3>Conclusions</h3> IL-9 levels are increased in RA patients, in whom it plays a crucial role. Th9 cells are the major producers of IL-9, and their prevalence is higher in RA patients than in healthy subjects, although they do not seem to affect the outcome of biological therapies. <h3>References</h3> Zhao P, Xiao X, Ghobrial RM, Li XC. IL-9 and Th9 cells: progress and challenges. Int Immunol. 2013;25(10):547-51. Licona-Limόn P, Henao-Mejia J, Temann AU, Gagliani N, Licona-Limόn I, Ishigame H, Hao L, Herbert DR, Flavell RA.Th9 Cells Drive Host Immunity against Gastrointestinal Worm Infection. Immunity. 2013;39(4):744-57. Kaplan MH. Th9 cells: differentiation and disease. Immunol Rev. 2013;252(1):104-15. Jäger A, Dardalhon V, Sobel RA, Bettelli E, Kuchroo VK. Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes. J Immunol. 2009;183(11):7169-77. <h3>Disclosure of Interest</h3> None declared
Abstract P1-08-05: Expression levels of sialyl transfereases and fucosyl transferases in breast cancer and their prognostic significance
Authors: AL Yu, K-H Liao, C-H Chang, Y-C Lin, T-C Fan, J-T Hung, H-L Yeo, R-J Lin, J-C Yu
Journal: Cancer Research (2016)

Abstract Aberrant expression of fucose or sialic acid containing glycans is prevalent in various cancers, including breast cancer. The addition of fucose and sialic acid to glycans is mediated by fucosyl transferases (FUTs) and sialyl transferases (STs), respectively. To explore the roles of these FUTs and STs in breast cancer, we collected 123 paired breast cancer specimens (tumor tissue and non-tumor tissue) and determined the RNA expression levels of 13 FUTs (FUT1-13) and 13 STs (ST3Gal1-6, ST6Gal1, ST6GalNAc1-4, ST6GalNAc6, ST8Sia1 and ST8Sia4) by q-PCR. The expression of 10 FUTs and 10 STs is significantly higher in tumor tissue than in non-tumor tissue by 1.2-4.09 folds. Notably, expression of FUT1 and ST3Gal1 appeared to be highest in triple negative subtype. Further multivariate Cox regression analysis showed a significant correlation between higher hazard ratios (HRs) for five-year relapse-free survival (RFS) and higher ST3Gal1 expression (N = 16, HR = 2.54, p = 0.02) or lower ST3Gal3 expression (N = 88, HR = 3.44, p &amp;lt; 0.001). As to the joint effects of high expression of ST3Gal1 and low expression of ST3Gal3 (N = 10) compared with low expression of ST3Gal1 and high expression of ST3Gal3 (N = 82), the HR was 5.5 (95% CI = 2.16-14.02, p = 0.0004) for RFS. The two gene additive model displayed a statistically significant HR of 2.33 for RFS (95% CI = 1.48-3.69, p = 0.0003). These results suggest that FUTs and STs play important roles in tumor progression. Citation Format: Yu AL, Liao K-H, Chang C-H, Lin Y-C, Fan T-C, Hung J-T, Yeo H-L, Lin R-J, Yu J-C. Expression levels of sialyl transfereases and fucosyl transferases in breast cancer and their prognostic significance. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-08-05.
Consistent definitions of tumor response.
Authors: S M Grunberg
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.4.609 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3514808 Consistent definitions of tumor response. S M GrunbergxS M GrunbergSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.4.609 PDF "Consistent definitions of tumor response.." Journal of Clinical Oncology, 4(4), pp. 609–610© 1986 by American Society of Clinical Oncology
Short-Term Dynamic Psychotherapy
Authors: Ragnhild Husby
Journal: Psychotherapy and Psychosomatics (1985)

Global assessment scale (GAS) has not been tested out on a group of neurotic out-patients earlier. The patients in this study were selected for short-term dynamic psychotherapy by defined selection criteria and were thus a fairly homogeneous group of patients. It could be demonstrated that GAS could be used as a supplement for describing patient characteristics both at the start of treatment and at the 5-year follow-up. GAS could further be used for measuring change for this patient population after short-term dynamic psychotherapy. GAS could not be used as a predictor for dynamic change at the 5-year follow-up.
Enzyme Changes Induced in Normal and Malignant Tissues With Chemical Agents. IV. Effect of &lt;italic&gt;Alpha&lt;/italic&gt;-Peltatin on Glucose Utilization by Sarcoma 37 and on the Adenosinetriphosphatase, Hexokinase, Aldolase, and Pyridine Nucleotide Levels of Sarcoma 37&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: V S WARAVDEKAR, A D PARADIS, J LEITER
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Enzyme Changes Induced in Normal and Malignant Tissues With Chemical Agents. IV. Effect of Alpha-Peltatin on Glucose Utilization by Sarcoma 37 and on the Adenosinetriphosphatase, Hexokinase, Aldolase, and Pyridine Nucleotide Levels of Sarcoma 37 Get access V. S. Waravdekar, V. S. Waravdekar Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Md.4 Search for other works by this author on: Oxford Academic PubMed Google Scholar Anita D. Paradis, Anita D. Paradis Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Md.4 Search for other works by this author on: Oxford Academic PubMed Google Scholar J. Leiter J. Leiter Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Md.4 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 1, August 1955, Pages 31–39, https://doi.org/10.1093/jnci/16.1.31 Published: 01 August 1955 Article history Received: 14 December 1954 Published: 01 August 1955
Updated Clinical Practice Guidelines on Heart Failure: An International Alignment
Authors: Elliott M. Antman, Jeroen Bax, Richard A. Chazal, Mark A. Creager, Gerasimos Filippatos, Jonathan L. Halperin, Steven Houser, JoAnn Lindenfeld, Fausto J. Pinto, Panos Vardas, Mary Norine Walsh, Kim A. Williams, Jose L. Zamorano
Journal: European Journal of Heart Failure (2016)
The Influence of Various Culture Media on the Growth of Earle's Strain L Cells and Chick-Heart Fibroblasts &lt;italic&gt;In Vitro&lt;/italic&gt;&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;,&lt;xref ref-type="fn" rid="fn2"&gt;3&lt;/xref&gt;
Authors: Relda Cailleau, Paul L. Kirk
Journal: JNCI Journal of the National Cancer Institute (1954)

The Influence of Various Culture Media on the Growth of Earle's Strain L Cells and Chick-Heart Fibroblasts In Vitro, Get access Relda Cailleau, Relda Cailleau Department of Biochemistry, University of California, Berkeley, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar Paul L. Kirk Paul L. Kirk Department of Biochemistry, University of California, Berkeley, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 295–303, https://doi.org/10.1093/jnci/15.2.295 Published: 01 October 1954 Article history Received: 30 April 1954 Published: 01 October 1954
A Survey of Transplantable and Transmissible Animal Tumors
Authors: Lucia J. Dunham, Harold L. Stewart
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article A Survey of Transplantable and Transmissible Animal Tumors Get access Lucia J. Dunham, Lucia J. Dunham Medical Officer Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Stewart Harold L. Stewart Chief Laboratory of Pathology, National Cancer Institute2, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 5, April 1953, Pages 1299–1377, https://doi.org/10.1093/jnci/13.5.1299 Published: 01 April 1953 Article history Received: 24 October 1952 Published: 01 April 1953
Severe Urticaria Following Erythromycin Therapy
Authors: Ananda S. Prasad
Journal: New England Journal of Medicine (1960)

UNTOWARD reactions to erythromycin are uncommon and usually of little consequence. Mild gastrointestinal symptoms have been reported from the use of this antimicrobic. Intramuscular injection may cause induration and discomfort at the site, and topical application rarely produces irritation. The allergenicity of this drug is believed to be of low degree.The purpose of this paper is to report a case of urticaria so severe that erythromycin therapy was stopped.Case ReportA 24-year-old man was admitted to Nemazee Hospital because of difficulty in walking of 4 months' duration. After a complete work-up an operation for herniated intervertebral disk was . . .
Establishment and Characterization of a Cloned Giant Cell Line From a Patient With Hodgkin's Disease&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: L Olsson, O Behnke, N Pleibel, F D'Amore, O Werdelin, K E Fry, H S Kaplan
Journal: JNCI Journal of the National Cancer Institute (1984)

The phenotypic characteristics of a cloned giant cell line, SU/RH-HD-1, established from the spleen of a patient with Hodgkin's disease were studied. The cells grew slowly, adhered to the culture vessel surface, and had an elongated, irregular shape. After trypsinization, they became spherical and measured 30-100 micron in diameter. Although most cells were mononuclear, binucleated and multinucleated cells could be identified in expanded cultures. The cells phagocytized latex and ink particles and were nonspecific esterase-positive, but they did not secrete lysozyme. They were Epstein-Barr nuclear antigen-negative, and their culture fluid supernatants were devoid of reverse transcriptase activity. Electron microscopy revealed cells with a pronounced smooth endoplasmic reticulum, free ribosomes, some filaments, and mitochondria. Many 0.5- to 1.0-micron invaginations (pits) were seen along the cell membrane. Nucleoli were enlarged and prominent in the very heterochromatic nuclei. The SU/RH-HD-1 cells had 10- to 100-micron-long pseudopodia that were sometimes forked or branching, as well as multiple stress fibers. Electron microscopic appearance was suggestive of that of macrophages. This interpretation of the results was substantiated by monoclonal antibody studies, which revealed that the cells express antigenic determinants distinctive for cells of the monocyte-macrophage lineage and by functional studies demonstrating that the cells are capable of specific antigen presentation to immune T-cells. The SU/RH-HD-1 cells were aneuploid and could be cloned, first in liquid culture by limiting dilution and later in semisolid medium. It was likely that the SU/RH-HD-1 cells were derived from the neoplastic giant cell population in Hodgkin's disease and that they originated from cells of the mononuclear phagocyte-reticulum cell lineage.
Disparities in Academic Dermatology
Authors: Jenna Lester, Bruce Wintroub, Eleni Linos
Journal: JAMA Dermatology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Recertification of psychiatrists: the time to act is now
Authors: S M Small
Journal: American Journal of Psychiatry (1975)

Because of the predictions of partial obsolescence for psychiatry as a profession and because of the increasing pressures of government, third-party payers, and a patient population that will no longer blindly follow physicians, psychiatrists must face the demands for professional accountability. The author suggests that to maintain high-quality care and continuing self-governance, psychiatrists must participate actively in self-assessment and continuing education programs.
Respiratory hypersensitivity reactions to NSAIDs in Europe: the global allergy and asthma network (GA<sup>2</sup>LEN) survey
Authors: J. S. Makowska, P. Burney, D. Jarvis, T. Keil, P. Tomassen, J. Bislimovska, G. Brozek, C. Bachert, J. Baelum, C. Bindslev-Jensen, J. Bousquet, P. J. Bousquet, C. Kai-Håkon, S. E. Dahlen, B. Dahlen, W. J. Fokkens, B. Forsberg, M. Gjomarkaj, P. Howarth, E. Salagean, C. Janson, L. Kasper, U. Kraemer, C. Louiro, B. Lundback, J. Minov, E. Nizankowska-Mogilnicka, N. Papadopoulos, A. G. Sakellariou, A. Todo-Bom, E. Toskala, J. E. Zejda, T. Zuberbier, M. L. Kowalski
Journal: Allergy (2016)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders.The GA2 LEN survey was conducted in 22 centers in 15 European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled. Questionnaires including questions about age, gender, presence of symptoms of asthma, allergic rhinitis, chronic rhinosinusitis, smoking status, and history of NSAID-induced hypersensitivity reactions were sent to participants by mail. Totally, 62 737 participants completed the questionnaires.The mean prevalence of NSAID-induced dyspnea was 1.9% and was highest in the three Polish centers [Katowice (4.9%), Krakow (4.8%), and Lodz (4.4%)] and lowest in Skopje, (0.9%), Amsterdam (1.1%), and Umea (1.2%). In multivariate analysis, the prevalence of respiratory reactions to NSAIDs was higher in participants with chronic rhinosinusitis symptoms (Odds Ratio 2.12; 95%CI 1.78-2.74), asthma symptoms in last 12 months (2.7; 2.18-3.35), hospitalization due to asthma (1.53; 1.22-1.99), and adults vs children (1.53; 1.24-1.89), but was not associated with allergic rhinitis.Our study documented significant variation between European countries in the prevalence of NSAID-induced respiratory hypersensitivity reactions, and association with chronic airway diseases, but also with environmental factors.
Newborn dopamine-beta-hydroxylase, minor physical anomalies, and infant temperament
Authors: J L Rapoport, C Pandoni, M Renfield, C R Lake, M G Ziegler
Journal: American Journal of Psychiatry (1977)

The authors examined newborn anomaly scores for 193 normal infants in relation to obstetrical history, newborn dopamine-beta-hydroxylase (DBH), and 5-month (N=185) and 1-year (N=123) infant behavior, determined by a questionnaire completed by their mothers. There was no significant relationship between anomaly score and obstetrical history or 5-month infant temperament; low significant correlations were found between newborn DBH and 1) infant irritability and unsociable response and 2) 1-year anomaly scores and reported activity levels. The authors discuss the possible importance of these findings.
The 1982 first-year resident in psychiatry
Authors: S H Weissman, P G Bashook
Journal: American Journal of Psychiatry (1984)

A 197-item questionnaire was distributed to the 541 medical students who matched into first-year postgraduate positions in psychiatry in 1982. The questionnaire obtained basic personal data, career plans before entering medical school, experiences in medical school, factors relating to selection of residency program, future plans, and attitude toward personal psychotherapy. The authors report the results for the 274 residents who completed the questionnaire (51% of the students). They explore the finding that first-year psychiatric residents do not plan careers in areas that the National Institute of Mental Health has defined as having priority--children and the aged.
Transverse Myelitis
Authors: Elliot M. Frohman, Dean M. Wingerchuk
Journal: New England Journal of Medicine (2010)

An otherwise healthy 28-year-old woman presents with progressive weakness for the past 3 days, numbness below her breasts, and urinary urgency. Neck flexion triggers an electrical sensation that radiates to the coccyx. Examination reveals moderate paraparesis with hyperreflexia, a left extensor plantar response, impaired vibratory and proprioceptive sensation, and a sensory level at T6. Magnetic resonance imaging reveals a lower cervical cord lesion that enhances after gadolinium administration, a finding consistent with transverse myelitis. How should she be further evaluated and treated?