tbuckley/cabot-search huggingface dataset:
THU0172 Long Term Safety of Etanercept in Elderly Subjects with Rheumatoid Arthritis in Daily Practice
Authors: A. Lurati, K. A. re, M. marrazza, D. bompane, M. scarpellini
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To report side effects seen in a clinical cohort of patients &gt;65 years old with Rheumatoid Arthritis treated with Etanercept and to compare the SEs rate with patients ≤ 65 years old. <h3>Methods</h3> All patients with RA that started Etanercept from November 2005 to November 2006 and referring to our Rheumatology Unit until November 2011 were included in this study and prospectively followed to collect side effects related to therapy (Group A patients ≤ 65 years old, group B &gt; 65 years old). All SEs observed during 5 years, primarily infective adverse event (IAE) and Serious adverse event (SAE), were collected. Data were analyzed with Mantel Cox survival analysis <h3>Results</h3> Eighty two patients were enrolled in this study from November 2005 to November 2006 and followed until November 2011: 31 (28 females, 3 males) aged ≤ 65 years (Group A), 52 (40 females, 11 males) aged &gt; 65 years (Group B). In the patients &gt; 65 years old the safety profile of Etanercept was similar than in patients ≤ 65 years old (p&gt;0.05) and the survival curves between the groups were similar (p&gt;0.05). Rates of infection were comparable across the groups (p&gt;0.05). Urinary tract infections and upper respiratory tract infections (including nasopharyngitis) were the most frequently reported IAEs. Also rates of SAEs were comparable in the two groups (p&gt;0.05) (Tab. 1) Mean survival time before that a first AE related to therapy with Etanercept was recorded was 29.6 months ±2.42 in the Group A, 31.3± 2.6 in the Group B. Median survival time was 31.7 months in the Group A and 34.4 in the Group B, (p&gt;0.05). No significant correlation has been found between the survival time until the first adverse event and the age (p=0.63). Mean survival time before definitive therapy suspension with Etanercept due to SAEs was 46.2 months ±2.99 in the ≤ 65 years old group and 47.7± 4.1 in the elderly group (p&gt;0.05). No significant correlation has been found between therapy duration when SAE occurred and the age used as a covariate in the Mantel Cox equation (p=0.728). Finally, a retention rate of 64.7 % at 5 years in the group &lt;65 years old and 63.0 % in the ≥ 65 years old group was observed <h3>Conclusions</h3> In our experience, anti-TNFα agent Etanercept has been safe in elderly patients; the risk of SEs (primarily IAE and SAE) in these patients was no greater than in subjects aged ≤ 65 years. However, such inhibitors are associated with various and numerous SEs, elderly patients with RA should be carefully monitored. <h3>Disclosure of Interest</h3> None Declared
Induction Chemotherapy (Ic) with Docetaxel, Cisplatin and 5-Fluorouracil (Tpf) Followed By Chemoradiotherapy (Crt) Concurrent with Fractionated Administration of High-Dose Cisplatin for Patients with Locally Advanced Scchn: Results of a Multicenter Phase 2 Feasibility Study
Authors: S. Okano, M. Tahara, T. Onoe, T. Enokida, T. Yamazaki, S. Zenda
Journal: Annals of Oncology (2014)
ASSOCIATION BETWEEN ANTI-CITRULLINATED PROTEIN ANTIBODIES AND LONG-TERM MORTALITY IN PATIENTS WITH ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION
Authors: Maaike Hermans, Daniel van der Velden, Tom Huizinga, Johan Kuiper, Rene Toes, Martin Schalij, Johan Jukema, Diane van der Woude
Journal: Journal of the American College of Cardiology (2016)
SAT0148 Short and Long-Term Biological Therapy in Refractory Uveitis of Behcet’S Syndrome. Multicenter Study of 108 Patients
Authors: V. Calvo-Río, R. Blanco, E. Beltrán, J. S-Bursón, M. Mesquida, A. Adán, M. Hdez-Grafella, E. Valls, L. Mtnez-Costa, A. Sellas, M. Cordero-Coma, M. D-Llopis, D. Salom, J. G-Serrano, N. Ortego, J. Herreras, A. Fonollosa, A. Aparicio, O. Maíz, A. Blanco, I. Torre, C. Fdez-Espartero, V. Jovani, D. Peitado, E. Pato, J. Cruz, C. Fdez-Cid, E. Aurrecoechea, M. García, M. Caracuel, C. Montilla, A. Atanes, F. Francisco, S. Insua, S. Glez-Suárez, A. Schez-Andrade, F. Gamero, L. Linares, F. Romero, J. García, J. Loricera, M. G-Gay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To assess response to biological therapy in uveitis associated to Behçet´s syndrome (BS) refractory to standard immunosuppressants (IS). <h3>Methods</h3> Study of 108 patients from 32 hospitals. All of them presented inadequate response to at least 1IS. Inflammation was evaluated according to <i>SUN</i> (Am J Ophthalmol 2005); macular thickness by optical coherence tomography (OCT). Results were expressed as mean±SD, or median [25t-75th(IQR)]. Comparisons were made between baseline and 1<sup>st</sup> week, 1<sup>st</sup>, 6<sup>th</sup> month, 1<sup>st</sup>, 2<sup>nd</sup>, 3<sup>rd</sup> and 4<sup>th</sup> year (Wilcoxon). <h3>Results</h3> We studied 108 patients/193 affected eyes (59M/49W); mean age 38.2±10.4 years (range 10-67). Before biologic onset they had received iv MethylP (32 cases), CyA (91), MTX (53) or AZA (62). Anti-TNF was 1st choice: infliximab (IFX)(65 cases) and adalimumab (ADA)(43); in monotherapy (22 cases) or in combination: CyA (49 cases), MTX (20), AZA (15), Micophenolate (1), or tacrolimus (1). In refractory or toxicity to 1<sup>st</sup> biologic was used; Golimumab (4 cases), Tocilizumab (1), RTX (1) and ETN (1). Anti-TNF follow-up was 35.4±20.2 months. Tyndall, vitritis and OCT showed a rapid and significant improvement at the 1<sup>st</sup> week. From biological onset to 2 years of follow-up patients showed an improvement of Tyndall from a median [IQR] of 1 [0-2] to 0 [0-0] (p&lt;0.001), vitritis, 1 [0-2] to 0 [0-0] (p&lt;0.001). At basal, 51 patients,(79 eyes) had macular thickening (OCT&gt;250μ) and 31 (44 eyes) had cystoid macular edema (CME)(OCT&gt;300μ). CME improved from 422.2±118.2 to 280.5±56.4 microns at 2 years (p&lt;0.001). <h3>Conclusions</h3> Biological therapy, especially IFX and ADA, yields short and long-term efficacy in uveitis refractory to standard IS in BS. <h3>Disclosure of Interest</h3> None Declared
EARLY AND LATE CARDIOPROTECTIVE EFFECTS OF INTRACORONARY ADMINISTRATION OF 4-CHLORODIAZEPAM IN A RAT MODEL OF ISCHEMIA/REPERFUSION
Authors: Christos Kapelios, Maria Nana, Styliani Vakrou, Christos Kontogiannis, Emmeleia Leventaki, Maria Anastasiou-Nana, Despina Perrea, Konstantinos Malliaras
Journal: Journal of the American College of Cardiology (2016)
False-Positive Results of a Gastrointestinal Bleeding Study Caused by an Ectopic Kidney
Authors: JOSE R. INFANTE, FRANCISCO M. GONZÁLEZ, JUAN A. VALLEJO, MIGUEL TORRES, CARMEN PACHECO, JOSE M. LATRE
Journal: Clinical Nuclear Medicine (2000)

A 64-year-old woman with a history of repeated bleeding episodes in the previous 4 years had several days of lower gastrointestinal bleeding and a low hematocrit concentration. Despite intensive searching (colonoscopy, arteriography, and upper gastrointestinal tract endoscopy), the site of the bleeding was not identified, and Tc-99m–labeled RBC scintigraphy was performed. Immediately after injection of the radiopharmaceutical, significant activity was visualized in the upper abdomen. Subsequent Tc-99m MAG3 renal scintigraphy showed that the activity was secondary to an ectopic right kidney, which was confirmed by ultrasound.
A8
Authors: Al Landry, Michael F. Hartshorne, John M. Bauman, Robert D. Karl, Michael F. Cawthon, Stephen R. Bunker, William H. Howard, Marion Hawkins
Journal: Clinical Nuclear Medicine (1984)

Landry, Al Jr.; Hartshorne, Michael F.; Bauman, John M.; Karl, Robert D. Jr.; Cawthon, Michael F.; Bunker, Stephen R.; Howard, William H. III; Hawkins, Marion Author Information
OC-064 Psychophysiological And Cortical Responses To Visually Induced Motion Sickness
Authors: AD Farmer, VF Ban, V Giampietro, P Andrews, Q Aziz
Journal: Gut (2014)

<h3>Introduction</h3> Nausea is an aversive experience, which negatively impacts on quality of life, adherence to treatment and is a cause for discontinuation of the development of novel compounds. Significant knowledge gaps remain in our understanding of the cortical and psychophysiological mechanisms involved in the genesis and maintenance of nausea. We aimed to develop and validate a readily administered a visually induced motion sickness (VIMS) stimulus to examine the psychophysiological changes induced by the stimulus and characterise the changes in cortical activity using functional magnetic resonance imaging (fMRI). <h3>Methods</h3> A 10-min video of motion and a control video of a still image were presented to 98 healthy volunteers (mean age 26 years, range 19–58 years, 53 male) in a randomised cross-over design. Validated questionnaires and visual analogue scales (VAS) were used for anxiety and nausea assessment. We monitored validated measures of autonomic and electrogastrographic activity at baseline and continuously thereafter. Subjects were stratified into quartiles based on nausea VAS scores with the upper and lower quartiles considered to be nausea sensitive and resistant respectively. Of these, 28 subjects of the 50 (mean age 25 years, range 20–49 years, 16 males, 11 nausea resistant) were exposed to the motion video during fMRI. <h3>Results</h3> All subjects completed the studies without vomiting. The motion video induced nausea in 57/98 subjects (57%) associated with elevation of median nausea VAS scores (2.0 (IRQ 1–3) vs. 1.0 (IRQ 1–1), p = 0.003). Nausea sensitive subjects had lower normogastria:tachygastria (p = 0.048), increased sympathetic (p = 0.002) and decreased parasympathetic tone (p = 0.03) during the motion video in comparison to the control video. The motion video resulted in heightened neuronal activity in the left and right cerebrum, temporal lobe, middle temporal gyrus and occipital lobe (p &lt; 0.004). Compared to nausea resistant subjects, the nausea sensitive group showed a paucity of activity in the left cerebrum, limbic areas and anterior cingulate cortex (p &lt; 0.001). <h3>Conclusion</h3> This study provides evidence to validate the motion video as a VIMS stimulus. Additionally, it demonstrates the cortical and psychophysiological changes induced by VIMS. These changes are as a result of the activation of a broad central network, reflecting the multi-dimensional nature of nausea. Sensitivity to VIMS may therefore be as a consequence of failure of, rather than excessive, activation of cortical areas concerned with the interoceptive and affective aspects of nausea. <h3>Disclosure of Interest</h3> None Declared.
Pseudohyperkalemia Due to Release of Potassium from White Blood Cells during Clotting
Authors: William R. Bronson, Vincent T. DeVita, Paul P. Carbone, Ernest Cotlove
Journal: New England Journal of Medicine (1966)

HYPERKALEMIA, such as occurs in renal failure or adrenal insufficiency, is associated with cardiac and neuromuscular abnormalities. Hartmann and his co-workers1 , 2 reported the phenomenon of pseudohyperkalemia, an elevation of serum potassium that does not reflect the level of plasma potassium in vivo. They concluded that the high potassium in serum developed in vitro by leakage from platelets during the clotting process.In the present study 2 patients with chronic myelogenous leukemia who demonstrated pseudohyperkalemia were investigated. A third patient in whom the phenomenon was demonstrated only by special study is included. In contrast to previous reports, the white cells and . . .
Reliability Assurance of Detection of EML4-ALK Rearrangement in Non–Small Cell Lung Cancer: The Results of Proficiency Testing in China
Authors: Yulong Li, Rui Zhang, Rongxue Peng, Jiansheng Ding, Yanxi Han, Guojing Wang, Kuo Zhang, Guigao Lin, Jinming Li
Journal: Journal of Thoracic Oncology (2016)
Gastroduodenal ulceration after selective internal radiation therapy of liver tumor
Authors: I. Wallstabe, G. Bakos, A. Plötner, A. Kretzschmar, D. Wegner, K. Hohdorf, J. Scheibe
Journal: Endoscopy (2012)

Image-guided interstitial brachytherapy is used for the treatment of primary and secondary liver tumors. Millions of non-biodegradable yttrium-90 (90Y)-imprinted microspheres with a diameter of 29 – 35 μm are selectively infused by a catheter into the branch of the hepatic artery supplying the tumor. Thereby, a radiation dose of 30 – 60 Gy can be applied to the tumor tissue. 90Y is a beta-emitter with an average tissue penetration depth of approximately 2.5 mm and a physical half-life of 2.67 days (64.2 hours) [1] [2]. Gastroduodenal ulceration occurs in less than 5 % after selective internal radiation therapy (SIRT) [2] [3] [4].
Continuous Improvement as an Ideal in Health Care
Authors: D M Berwick
Journal: New England Journal of Medicine (1989)

Imagine two assembly lines, monitored by two foremen.Foreman 1 walks the line, watching carefully. "I can see you all," he warns. "I have the means to measure your work, and I will do so. I will find those among you who are unprepared or unwilling to do your jobs, and when I do there will be consequences. There are many workers available for these jobs, and you can be replaced."Foreman 2 walks a different line, and he too watches. "I am here to help you if I can," he says. "We are in this together for the long . . .
Fatal Encephalitis Due to Variant B Human Herpesvirus-6 Infection in a Bone Marrow-Transplant Recipient
Authors: William R. Drobyski, Konstance K. Knox, David Majewski, Donald R. Carrigan
Journal: New England Journal of Medicine (1994)

Human herpesvirus-6 (HHV-6) is the causative agent of exanthem subitum1 and febrile illnesses2 in children. More recently, HHV-6 has been shown to infect the recipients of bone marrow transplants and has been implicated in interstitial pneumonitis3,4 and bone marrow suppression5 after transplantation. The pathogenicity of HHV-6, however, has yet to be fully delineated in either immunocompetent or immunocompromised hosts. In some children with exanthem subitum, seizures, encephalopathy, and the detection of HHV-6 DNA in cerebrospinal fluid have provided circumstantial evidence that HHV-6 can infect the central nervous system6,7. Nevertheless, these studies have failed to document the direct . . .
Abstract P6-06-04: p53 and p16 as Modifiers of HERV-K in Invasive Pleomorphic Lobular Carcinoma and Classic Lobular Carcinoma of Breast
Authors: Tahereh Dadfarnia, Ya Xu, Sandra S Hatch, Jianli Dong, Mahmoud A Eltorky
Journal: Cancer Research (2012)

Abstract Withdrawn by Author Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P6-06-04.
SPLEEN STIFFNESS IS LOWER WHEN MEASURED IN THE RIGHT LATERAL POSITION COMPARED TO THE SUPINE POSITION
Authors: J L Chin, G Chan, J D Ryan, P A McCormick
Journal: Gut (2013)

<h3>Introduction</h3> Spleen stiffness has been shown to correlate with hepatic venous pressure gradient and can predict oesophageal varices. At present, no valid criteria or standardized method for spleen stiffness measurement exist. <h3>Aims/Background</h3> This study investigated the influence of different lying positions on spleen stiffness measurements. <h3>Method</h3> Twelve spleen stiffness measurements were performed in 5 patients using Fibroscan<sup>®</sup> before and after liver transplantation. For spleen stiffness, ultrasonography was first used to confirm splenic position prior to elastography. Spleen stiffness was measured in the right lateral and supine positions. Criteria for valid liver stiffness [&gt;10 successful measurements, interquartile range (IQR)&lt;30%, success rate &gt;60%] were applied to spleen stiffness. <h3>Results</h3> Three spleen stiffness measurements were prior to liver transplantation and nine measurements were done at different time intervals after transplant. Prior to liver transplantation, all spleen stiffness measurements reached the maximum detection limit of the Fibroscan<sup>®</sup> and were excluded from analysis of different lying positions. Measuring spleen stiffness in the right lateral position yielded significantly lower stiffness compared to measurements in the supine position, with a median difference of 16.7% (IQR 14.6–23.7%) (n=9; p&lt;0.01). When spleen stiffness measured in the right lateral decubitus was compared to the supine position, no significant differences were observed in IQR/Median [0.08 (0–0.19) versus 0.10 (0.04–0.19); p=0.76] or success rate (n=12; p=0.59). <h3>Conclusion</h3> We showed that spleen stiffness measured in the right lateral position is significantly lower than measurements in the supine position. This may reflect a local reduction in splenic venous pressure in the right lateral decubitus position.
Abstract 2173: Cytokeratin-19, a predictive marker and an early determinant of progenitor-derived hepatocellular carcinoma
Authors: Jesper B. Andersen, Roberto Loi, Andrea Perra, Valentina M. Factor, Giovanna M. Ledda-Columbano, Amedeo Columbano, Snorri S. Thorgeirsson
Journal: Cancer Research (2010)

Abstract Background: Human hepatocellular carcinoma (HCC) is a heterogeneous disease of distinct clinical subgroups. A principal source of tumor heterogeneity may be cell type of origin which in liver includes hepatocyte and/or adult stem/progenitor cells. Objective: To address this issue, we investigated the molecular mechanisms underlying the fate of the enzyme-altered preneoplastic lesions in the resistant hepatocyte (RH) model. Methods: Sixty samples classified as focal lesions, adenoma, early and advanced HCCs were micro-dissected after morphological and immunohistochemical evaluation and subjected to global gene expression profiling. Results: The analysis of progression of the persistent GSTP+ focal lesions to fully developed HCC showed that about 50% of persistent nodules and all HCCs expressed CK19 whereas 14% of remodeling nodules were CK19+. Unsupervised hierarchical clustering of the expression profiles also grouped the samples according to CK19 expression. Further, supervised analysis using the differentially expressed genes in each cluster combined with the gene connectivity tools identified 1308 unique genes and a predominance of the AP-1/JUN network in the CK19+ lesions. In contrast, the CK19-negative cluster exhibited only limited molecular changes (156 differentially expressed genes vs. normal liver) consistent with remodeling towards differentiated phenotype. Finally, comparative functional genomics revealed a stringent clustering of CK19+ early lesions and advanced HCCs with human HCCs characterized by poor prognosis. Furthermore, the CK19 associated gene expression signature accurately predicted the patient survival (P&amp;lt;0.009) and tumor recurrence (P&amp;lt;0.006). Conclusion: Our data establish CK19 as a prognostic marker of early neoplastic lesions and strongly suggest the progenitor derivation of HCC in the rat RH model. The capacity of the CK19 associated gene signature to stratify HCC patients according to clinical prognosis indicates the usefulness of the RH model for studies of stem/progenitor-derived HCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2173.
Case 2-2005
Authors: Karen K. Ballen, Robert P. Hasserjian
Journal: New England Journal of Medicine (2005)

A 39-year-old woman who had recently emigrated from Greece had multiple episodes of headache, neck pain, photophobia, and fever over a three-month period. The cerebrospinal fluid contained predominantly lymphocytes and monocytes. The results of a tuberculin skin test and antibody titers for brucella were positive. All cultures and viral tests were negative. Peripheral-blood monocytosis with rare immature myeloid cells developed. The differential diagnosis and management are discussed.
GE-36 * MOLECULAR-GENETIC AND CLINICAL CHARACTERISTICS OF THE "ASTROCYTIC" GLIOMAS WITH TOTAL 1p19q LOSS
Authors: S. Tanaka, H. Sasaki, T. Kimura, K. Kameyama, T. Nakamura, Y. Kitamura, T. Miwa, Y. Hirose, K. Yoshida
Journal: Neuro-Oncology (2014)

BACKGROUND: Although 1p19q codeletion is associated with better response to therapy and longer survival in oligodendroglial gliomas, molecular-genetic and clinical characteristics of "astrocytic" gliomas with codeletion have not been well elucidated at the moment. METHODS: We collected 57 gliomas with total 1p19q loss from among 183 gliomas of WHO grade II or III surgically treated in Keio University Hospital between 1990 and 2010. Those tumors were classified to oligodendroglial or "astrocytic" gliomas by institutional diagnosis based on WHO criteria of each times. Chromosomal copy number abberation (CNA, by comparative genomic hybridization (CGH)), IDH 1/2 mutation, and promoter methylation of MGMT were assessed. Survival outcome was compared between two histological groups. Since criteria of oligodendroglial tumor has changed overtime, analyses have also been performed after histopathological re-assessment by a single pathologist with the current criteria. RESULTS: 57 codeleted gliomas included 37 oligodendroglial, 16 astrocytic, and 4 unclassified low-grade gliomas by institutional diagnosis. By CGH, gain on 11q was specifically detected in oligodendroglial tumors. Gain on chromosome 7 and loss on 10p were more frequent in "astrocytic" gliomas. Frequency of IDH gene mutations and MGMT methylation was similary high in the two histological groups. Kaplan-Meier curves for overall survival (OS) of the patients with codeleted oligodendroglial and "astrocytic" tumors overlapped, and median OS was 175 and 170 months, respectively. Analyses after histopathological re-assessment by a single pathologist showed almost identical results. CONCLUSIONS: "Astrocytic" gliomas with 1p19q codeletion are likely to have comparable biological characteristics to codeleted oligodendroglial gliomas.
FRI0580-HPR Correlation between Self-Reported Physical Function and Isokinetic Total Muscle Work in Early Degrees of Knee Osteoarthritis
Authors: M. Petrella, P.R.M.D.S. Serrão, K. Gramani-Say, L.F.A. Selistre, G.H. Gonçalves, S.M. Mattiello
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Abstract</h3> <b>Review of:</b> Horne AW, Vincent K, Hewitt CA, <i>et al</i>. Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial. <i>Lancet</i>. 2020; 396:909–17.
Case 1-2016
Authors: Nancy Berliner, Chandana Kurra, David Chou
Journal: New England Journal of Medicine (2016)

An 18-year-old man presented with fever, abdominal pain, and thrombocytopenia. Abdominal imaging studies showed nonspecific fluid collection and necrotic lymph nodes, and there were elevated levels of C-reactive protein and ferritin. A diagnostic procedure was performed.