tbuckley/cabot-search huggingface dataset:
Fibrous Dysplasia Mimicking Malignancy on 68Ga-DOTATATE PET/CT
Authors: Georgios Z. Papadakis, Corina Millo, Samira M. Sadowski, Apostolos H. Karantanas, Ulas Bagci, Nicholas J. Patronas
Journal: Clinical Nuclear Medicine (2017)

Fibrous dysplasia of the bone is a developmental benign skeletal disorder characterized by replacement of normal bone and normal bone marrow with abnormal fibro-osseous tissue. We report on a case of a biopsy-proven fibrous dysplasia lesion in the left temporal bone, with intensely increased activity (SUVmax, 56.7) on 68Ga-DOTATATE PET/CT. The presented data indicate cell surface overexpression of somatostatin receptors by fibrous dysplastic cells and highlight the need of cautious management of 68Ga-DOTATATE–avid bone lesions, which could mimic malignancy especially in patients with history of neuroendocrine tumors.
Lenalidomide, Bendamustine, and Rituximab As First-Line Therapy for Patients &gt; 65 Years with Mantle Cell Lymphoma: Results From the Phase I Portion of the Nordic Lymphoma Group MCL4 (LENA-BERIT) Trial
Authors: Mats Jerkeman, Arne Kolstad, Anna Laurell, Riikka Räty, Kirsten Grønbæk, Lone Bredo Pedersen, Christian H. Geisler
Journal: Blood (2011)
Risk of EBV-Positive Hodgkin Lymphoma Varies Over 30-Fold by HLA Class I Genotype and History of Infectious Mononucleosis.
Authors: Ruth Jarrett, Paul CD Johnson, Klaus Rostgaard, Annette Lake, Lesley Shield, Ann-Margaret Little, Karin Ekstrom-Smedby, Hans Olov Adami, Bengt Glimelius, Stephen Hamilton Dutoit, Eleanor Kane, G. Malcolm Taylor, Alex McConnachie, Lars P Ryder, Christer Sundstrom, Paal Skytt Andersen, Ellen T Chang, Freda Alexander, Mads Melbye, Henrik Hjalgrim
Journal: Blood (2009)
I can’t stand him (or her)
Authors: Kaustubh G Joshi
Journal: BMJ (2017)

It was another busy night in the emergency department. As I was about to interview the next patient, the nurse came over and said, “He’s back.” I didn’t even have to ask who was back. I felt my blood pressure rise, I muttered an expletive, and then I said, “My night is ruined.”

This patient is an example of patients …
The Hibernator Microbiome: Host-Bacterial Interactions in an Extreme Nutritional Symbiosis
Authors: Hannah V. Carey, Fariba M. Assadi-Porter
Journal: Annual Review of Nutrition (2017)

Animals that undergo seasonal cycles of feeding and fasting have adaptations that maintain integrity of organ systems when dietary nutrients are lacking. Food deprivation also challenges the gut microbiota, which relies heavily on host diet for metabolic substrates and the gastrointestinal tract, which is influenced by enteral nutrients and microbial activity. Winter fasting in hibernators shifts the microbiota to favor taxa with the capacity to degrade and utilize host-derived substrates and disfavor taxa that prefer complex plant polysaccharides. Microbiome alterations may contribute to hibernation-induced changes in the intestinal immune system, epithelial barrier function, and other host features that are affected by microbial short-chain fatty acids and other metabolites. Understanding mechanisms by which the hibernator host and its gut symbionts adapt to the altered nutritional landscape during winter fasting may provide insights into protective mechanisms that are compromised when nonhibernating species, such as humans, undergo long periods of enteral nutrient deprivation.
Association of TLR-4 Mutations in Host and Donor Cells and the Risk for Acute GVHD after Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Takehito Imado, Tsuyoshi Iwasaki, Takanori Kuroiwa, Sachie Kitano, Hajime Sano, Hiroyasu Ogawa
Journal: Blood (2006)
STUDIES OF MOUSE POLYOMA VIRUS INFECTION
Authors: Wallace P. Rowe, Janet W. Hartley, John D. Estes, Robert J. Huebner
Journal: The Journal of Experimental Medicine (1959)

THREE PROCEDURES HAVE BEEN COMPARED FOR USEFULNESS IN TITRATION AND DETECTION OF POLYOMA VIRUS: production of cytopathic effect (CPE) in mouse embryo tissue culture, production of HI antibody after inoculation into weanling mice (MAP test), and production of tumors in suckling hamsters during a 3 to 5 week observation period. The tissue culture and mouse antibody production tests were generally comparable in sensitivity, reproducibility, and time required to obtain results. Titration by tumor production in suckling hamsters was not suitable for quantitation because of marked variation in susceptibility among animals. Virus was detected in tissues of normal mice from spontaneously infected colonies by either production of CPE in mouse embryo tissue culture or by the MAP test; virus was found in organs of 15 (58 per cent) of 26 mice with antibody, and 2 (8 per cent) of 24 mice without antibody.
Studying hematopoiesis using single-cell technologies
Authors: Fang Ye, Wentao Huang, Guoji Guo
Journal: Journal of Hematology & Oncology (2017)

Hematopoiesis is probably the best-understood stem cell differentiation system; hematopoietic stem cell (HSC) transplantation represents the most widely used regenerative therapy. The classical view of lineage hierarchy in hematopoiesis is built on cell type definition system by a group of cell surface markers. However, the traditional model is facing increasing challenges, as many classical cell types are proved to be heterogeneous. Recently, the developments of new technologies allow genome, transcriptome, proteome, and epigenome analysis at the single-cell level. For the first time, we can study hematopoietic system at single-cell resolution on a multi-omic scale. Here, we review recent technical advances in single-cell analysis technology, as well as their current applications. We will also discuss the impact of single-cell technologies on both basic research and clinical application in hematology.
Serum Proteomic Analysis of Multiple Myeloma Subjects Treated with Daratumumab Monotherapy
Authors: Tineke Casneuf, Andrew Lysaght, Clare LeFave, Jaime Bald, Brendan Weiss, Niels W.C.J. van de Donk, Henk M. Lokhorst, Tahamtan Ahmadi, A. Kate Sasser
Journal: Blood (2015)
Abstract 238: Molecular Identity of Cardiac Mitochondrial Chloride Intracellular Channel Proteins and Their Role in Mitochondrial Function
Authors: Devasena Ponnalagu, Shubha Gururaja Rao, Harpreet Singh
Journal: Circulation Research (2015)

Introduction: Mitochondria are primary target organelles for cardioprotection. Rabbit heart and cardiomyocytes showed increased infarction upon treatment with IAA-94, a known chloride intracellular channel (CLIC) inhibitor implicating role of CLICs in cardioprotection. There are six CLIC homologs (CLIC1-6), but the molecular identity of cardiac mitochondrial CLICs and their functional roles are not deciphered. We aim to determine the identity of cardiac mitochondrial CLICs and establish their role in mitochondrial function to understand the mechanism of CLIC-mediated cardioprotection. Methods: Hearts were isolated from 2-3 months old SD rats for all the experiments. qPCRs were performed to determine the abundance of CLIC1-6 and corroborated by Western blot using specific antibodies. Immunofluorescence was performed on neonatal and adult cardiomyocytes. Percoll-purified mitochondria were also probed with Western blot, immuno organelle chemistry and Mass spectrometry to establish the presence of CLICs. In order to determine their role in mitochondrial function, spectrofluorimetric analysis were performed to measure the reactive oxygen species (ROS) production using amplex red and calcium retention capacity (CRC) using calcium green. Results: We have discovered that CLIC4, CLIC5 and CLIC1 as the most abundant paralogs in rat heart using qRT PCR and corroborated their presence by Western blot. CLIC4 and CLIC5, not CLIC1 were found to be present in mitochondria of neonatal and adult cardiomyocytes. Percoll-purified mitochondria further showed presence of CLIC4 and CLIC5 where they colocalizes with mitochondria (45+/-2 and 74+/-3, n=3, respectively). Over-expressing CLICs in H9C2 cells showed mitochondrial localization of CLIC4 and CLIC5 and not CLIC1 establishing them as mitochondrial anion channels. Blocking of CLICs with IAA-94 modulated the ROS production at both complex I and II/III of electron transport chain of mitochondria. Further IAA-94 reduced CRC of mitochondria by 83+/-6%, n=4. Conclusions: We have established that CLIC4 and CLIC5 are the cardiac mitochondrial anion channels and their activity regulates the function of mitochondria hence playing a direct role in cardioprotection from ischemia-reperfusion injury.
Rituximab-Cyclophosphamide-Dexamethasone (RCD) Combination In the Management of Autoimmune Cytopenias Associated with Chronic Lymphocytic Leukaemia
Authors: Anne-Sophie Michallet, Julien Rossignol, Lucie Oberic, Muriel Picard, Audrey Garon, Christophe Willekens, Remy Dulery, Xavier Leleu, Bruno Cazin, Loic Ysebaert
Journal: Blood (2010)
Long-term clinical outcomes of endoscopic submucosal dissection for colorectal neoplasms in 423 cases: a retrospective study
Authors: Masayoshi Yamada, Yutaka Saito, Hiroyuki Takamaru, Hayato Sasaki, Takuya Yokota, Yasushi Matsuyama, Yoshinori Sato, Taku Sakamoto, Takeshi Nakajima, Hirokazu Taniguchi, Shigeki Sekine, Takahisa Matsuda
Journal: Endoscopy (2017)

Background and study aim Endoscopic submucosal dissection (ESD) is known as a curative treatment for colorectal superficial neoplasms. There is however a need for more long-term clinical data to establish the full advantages of colorectal ESD regarding very low recurrence rates. The aim of this retrospective study was to determine long-term clinical outcomes of colorectal ESD. Methods A total of 423 lesions treated by ESD for colorectal adenoma/dysplasia or adenocarcinoma between 1998 and 2008 at a single high volume referral center were included. We conducted a retrospective survey on patients with follow-up and obtained complete 1-, 3-, and 5-year outcome data for 358 (85 %), 292 (69 %), and 209 (49 %) lesions, respectively. Curative resection was defined when the pathological specimen had carcinoma-free resection margins, irrespective of piecemeal or en bloc resection, without submucosal deep invasion (≥ 1000 µm), lymphovascular involvement, or a poorly differentiated adenocarcinoma component. Results After a median 4.9 years of follow-up, the 3-year overall cumulative endoscopic recurrence rate and cancerous recurrence rate were 2.9 % (95 % confidence interval [95 %CI] 1.2 - 4.7) and 1.1 % (0 - 2.1), respectively. The 5-year overall cumulative endoscopic recurrence and cancerous recurrence rates were 3.8 % (1.7 - 5.9) and 1.6 % (0.1 - 3.0), respectively. In 361 lesions eligible for endoscopic follow-up, the 3-year endoscopic recurrence and cancerous recurrence rates were 2.4 % (0.8 - 4.1) and 0.4 % (0 - 1.4), respectively. Multivariate analysis revealed that piecemeal resection and submucosal deep tumor invasion were associated with recurrence. Conclusions The current study demonstrated favorable long-term clinical outcomes of colorectal ESD when en bloc curative resection is achieved.
High Response Rate and Improved Exercise Capacity and Quality of Life with a New Regimen of Darbepoetin Alfa (DAR) +/−G-CSF in Lower-Risk MDS : a Phase II Study.
Authors: Charikleia Kelaidi, Odile Beyne-Rauzy, Thorsten Braun, Pierre Cougoul, Lionel Ades, Fabien Pillard, Christine Lamberto, Tony Jernival, Edith Mortera, Agnes Guerci, B. Choufi, Aspasia Stamatoullas, Borhane Slama, Benoît De Renzis, S. Ame, Damaj Ghandi, Françoise Boyer, Marie-Pierre Chaury, Laurence Legros, Stéphane Cheze, Anna Testu, Emmanuel Gyan, Marie C Bene, Christian Rose, Francois Dreyfus, Pierre Fenaux
Journal: Blood (2009)
Prior Granulocyte Colony-Stimulating Factor Treatment Enhances the Immediate and Transient Output of Primitive Hematopoietic Cells in the Blood of Normal Adult Human Donors Treated with Plerixafor
Authors: Paul H. Miller, Naoto Nakamichi, Gabrielle Rabu, Kirk R. Schultz, David M. Jones, Stephen Couban, Connie J. Eaves
Journal: Blood (2014)
High Dose Therapy (HDCT) and Autologous Haematopoietic Stem Cell Transplantation (aSCT) in Paediatric Patients with Recurrent or Refractory Hodgkin’s Disease (HD): Results and Outcome.
Authors: Arcangelo Prete, Federico Bonetti, Roberto Rondelli, Simone Cesaro, Sandro Dallorso, Claudio Favre, Franca Fagioli, Chiara Messina, Roberta Burnelli, Franco Locatelli, Andrea Pession
Journal: Blood (2005)
Evi-1 Regulates Myelopoiesis and Hematopoietic Stem Cell Development in Zebrafish and Human Pluripotent Stem Cells
Authors: Martina Konantz, Matthias Grauer, Sarah Grzywna, Martijn Brugman, Lothar Kanz, In-Hyun Park, George Q. Daley, Christopher Baum, Claudia Lengerke
Journal: Blood (2011)
Clinicopathological and Chromosomal Analysis of Small Intestinal Malignant Lymphoma using Fluorescence in situ Hybridization on Paraffin-Embedded Tissue Sections.
Authors: Naohisa Yoshida, Kenichi Nomura, Yosuke Matsumoto, Hideyuki Konishi, Shoji Mitsufuji, Shigeo Horiike, Tomohiko Taki, Masuji Morita, Kazuhiro Nishida, Takeshi Okanoue, Shigeo Nakamura, Masafumi Taniwaki
Journal: Blood (2004)
A Novel Targeted Therapeutic Approach to Multiple Myeloma Using Tumor Specific Anti-Sense RNA Sequences
Authors: Zhi-Wei Li, Dror Shalitin, Jing Shen, Michael Share, Mingjie Li, Cathy S Wang, Eric Sanchez, Jeffrey A Steinberg, Haiming Chen, Benjamin Bonavida, James R. Berenson
Journal: Blood (2008)
Inflammatory breast cancer (IBC): A retrospective analysis of 239 patients treated in a single institution
Authors: L. Vanlemmens, C. Desauw, Y. Belkacemi, S. Giard, M.-C. Baranzelli, L. Deschildre, C. Pasquier, C. Fournier, J. Bonneterre
Journal: Journal of Clinical Oncology (2005)

763 Background: IBC is a rare clinical entity often considered together with Locally Advanced Breast Cancer(LABC); however, when compared to the LABC, the IBC has a poor prognosis; very few studies, often with a limited number of patients, have been published. Methods: 239 patients were diagnosed with IBC between 1985 and 1995. The diagnosis was ascertained by cytology in 89% of the patients on the breast tumor and in 55% on lymph nodes. A biopsy was done in 26% of the tumors. Histological features were studied at the time of surgery in the 60 patients operated after chemotherapy. Median age was 52.6 years, 57% were postmenopausal; most patients had a palpable breast tumor (89%) with a mean diameter of 7 cm and axillary lymph nodes (80%). 216 patients received chemotherapy (4 to 8 courses), 18 hormonotherapy only, followed by loco-regional treatment (surgery in 60 patients and radiation therapy in 219). DFS and OS were studied using Kaplan Meyer Method: Results: Response to chemotherapy was assessed clinically: complete: 22% partial: 46%, stabilisation: 14%, progressive disease: 16%; 2% were not evaluable. No complete pathological response was observed in 60 patients who were operated. 63% out of 71 of the tumors were ER and PR negative. Median duration of follow-up of alive patients was 10.6 years. The median duration of DFS was 1.4 years. The 5- and 10-years relapse-free survival rates were 11% and 8% respectively. The median survival was 2.7 years. The 5- and 10-years overall survival rates were 30% and 12% respectively. Conclusions: These results obtained in one of the greatest cohorts of patients published to date confirm that IBC have to be considered separately from LABC and have a very poor prognosis. Their management has to be based on new strategies. No significant financial relationships to disclose.
Low-Density Lipoprotein Receptor–Related Protein 1 Prevents Early Atherosclerosis by Limiting Lesional Apoptosis and Inflammatory Ly-6C <sup>high</sup> Monocytosis
Authors: Patricia G. Yancey, Yu Ding, Daping Fan, John L. Blakemore, Youmin Zhang, Lei Ding, Jiabao Zhang, MacRae F. Linton, Sergio Fazio
Journal: Circulation (2011)

Background— We previously demonstrated that macrophage low-density lipoprotein receptor (LDLR)–related protein 1 (LRP1) deficiency increases atherosclerosis despite antiatherogenic changes including decreased uptake of remnants and increased secretion of apolipoprotein E (apoE). Thus, our objective was to determine whether the atheroprotective effects of LRP1 require interaction with apoE, one of its ligands with multiple beneficial effects. Methods and Results— We examined atherosclerosis development in mice with specific deletion of macrophage LRP1 (apoE −/− MΦLRP1 −/− ) and in LDLR −/− mice reconstituted with apoE −/− MΦLRP1 −/− bone marrow. The combined absence of apoE and LRP1 promoted atherogenesis more than did macrophage apoE deletion alone in both apoE-producing LDLR −/− mice (+88%) and apoE −/− mice (+163%). The lesions of both mouse models with apoE −/− LRP1 −/− macrophages had increased macrophage content. In vitro, apoE and LRP1 additively inhibit macrophage apoptosis. Furthermore, there was excessive accumulation of apoptotic cells in lesions of both LDLR −/− mice (+110%) and apoE −/− MΦLRP1 −/− mice (+252%). The apoptotic cell accumulation was partially due to decreased efferocytosis as the ratio of free to cell-associated apoptotic nuclei was 3.5-fold higher in lesions of apoE −/− MΦLRP1 −/− versus apoE −/− mice. Lesion necrosis was also increased (6 fold) in apoE −/− MΦLRP1 −/− versus apoE −/− mice. Compared with apoE −/− mice, the spleens of apoE −/− MΦLRP1 −/− mice contained 1.6- and 2.4-fold more total and Ly6-C high monocytes. Finally, there were 3.6- and 2.4-fold increases in Ly6-C high and CC-chemokine receptor 2–positive cells in lesions of apoE −/− MΦLRP1 −/− versus apoE −/− mice, suggesting that accumulation of apoptotic cells enhances lesion development and macrophage content by promoting the recruitment of inflammatory monocytes. Conclusion— Low-density lipoprotein receptor protein 1 exerts antiatherogenic effects via pathways independent of apoE involving macrophage apoptosis and monocyte recruitment.
Bendamustine Salvage Therapy for T-Cell Non Hodgkin Lymphoma
Authors: Francesco Zaja, Luca Baldini, Stefano Luminari, Andrés J.M. Ferreri, Alberto Grossi, Flavia Salvi, Renato Zambello, Stefano Volpetti, Maria Cecilia Goldaniga, Renato Fanin
Journal: Blood (2012)
Surgical management of patients with progressing metastatic gastrointestinal stromal tumors receiving sunitinib treatment: A prospective cohort study
Authors: Chun-Nan Yeh, Shang-Yu Wang, Chun-Yi Tsai, Yen-Yang Chen, Ching-Ting Liu, Kun-Chun Chiang, Tsung-Wen Chen, Yu-Yin Liu, Ta-Sen Yeh
Journal: International Journal of Surgery (2017)
Comparison of Allogeneic Hematopoietic Cell Transplantation and Chemotherapy as Post-Remission Strategy in Elderly Patients with Non-M3 AML in CR1: Retrospective Analysis with 1036 Patients.
Authors: Saiko Kurosawa, Takuhiro Yamaguchi, Naoyuki Uchida, Toru Sakura, Kensuke Usuki, Masato Watanabe, Takuya Yamashita, Heiwa Kanamori, Junji Tomiyama, Yuichiro Nawa, Shingo Yano, Jin Takeuchi, Kazuaki Yakushiji, Fumiaki Sano, Nobuhiko Uoshima, Yasuhito Nannya, Yoshiyuki Moriuchi, Yoichi Takaue, Takahiro Fukuda
Journal: Blood (2009)
A Retrospective Analysis of Gastric Diffuse Large B-Cell Lymphoma with or without MALT Component
Authors: Xiaowu Li, Bing Xia, Shanqi Guo, Eduardo M. Sotomayor, Yong Yu, Hongliang Yang, Haifeng Zhao, Zhigang Zhao, Xiaofang Wang, Yafei Wang, Yizhuo Zhang
Journal: Blood (2012)
Phase 1 Study of Weekly Vincristine Sulfate (VCR) Liposomes Injection (VSLI, Marqibo™) Plus Dexamethasone in Adults with Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
Authors: Deborah A. Thomas, Hagop M Kantarjian, Wendy Stock, Leonard Heffner, Sue Hirabayashi, Biao Lu, Steven R. Deitcher, Susan O’Brien
Journal: Blood (2008)
Negative Hematopoietic Scaffold Lnk Upregulates Integrin Outside-In Signaling in Platelets.
Authors: Koji Eto, Hitoshi Takizawa, Hidekazu Nishikii, Jun Seita, Atsushi Oda, Noriko Tamura, Shinya Goto, Kiyoshi Takatsu, Satoshi Takaki, Hiromitsu Nakauchi
Journal: Blood (2005)
Impact of High Dose Cyclophosphamide on the Outcome of Autologous Stem Cell Transplant in Patients with Newly Diagnosed Multiple Myeloma,
Authors: Wendi A. Bacon, Gwynn D. Long, David A. Rizzieri, Mitchell E. Horwitz, John P. Chute, Keith M. Sullivan, Amanda Yopp, Angela Johns, Nelson J. Chao, Cristina Gasparetto
Journal: Blood (2011)
Leukemic and Hematopoietic Stem Cells Compete for the Same Functional Marrow Niche in a MLL-AF9 Murine Leukemia Model
Authors: Ronan G. Desmond, Taha Bat, Olena Kamenyeva, Benjamin Mizukawa, James C. Mulloy, Andre Larochelle, Cynthia E. Dunbar
Journal: Blood (2012)
End-Alveolar Carbon Monoxide As a Measure of Erythrocyte Survival and Hemolytic Severity in Sickle Cell Disease
Authors: Caterina P. Minniti, John H. Baird, Dihua Xu, Laurel Mendelsohn, Rehan Saiyed, Mary Jackson, James Nichols, Daniel Kim-Shapiro, Yang Xia, Gregory J. Kato
Journal: Blood (2014)
CD3-Negative CD4+ T-Cells: A Useful Diagnostic Tool with High Specificity in Angioimmunoblastic Lymphadenopathy (AILD)-Type T-Cell Lymphoma
Authors: Anju Singh, Anne Flörcken, Antje van Lessen, Bernd Dörken, Antonio Pezzutto, Jörg Westermann
Journal: Blood (2008)
Ротавірус-індукована активація механізмів захисту адаптивної імунної системи організму дитини
Authors: O.Ye. Abaturov, Yu.Yu. Stepanova
Journal: GASTROENTEROLOGY (2020)

В огляді висвітлено сучасні уявлення про участь адаптивної імунної системи в саногенезі ротавірусної інфекції. Показано, що провідним компонентом механізмів неспецифічного захисту організму, що беруть участь у розвитку ротавірусної інфекції, є Toll-подібні (TLR) і RIG-подібні рецептори (RLR). Активація TLR і RLR обумовлює розвиток запального процесу й індукцію синтезу антимікробних пептидів.
Russia plans to ban tobacco sales to all citizens born after 2014
Authors: Owen Dyer
Journal: BMJ (2017)

The Russian health ministry’s newly announced long term plan for tobacco control includes a measure to ban the purchase of tobacco for the entire generation now being born, even after they reach adulthood.

The first citizens facing a lifetime smoking ban would turn 18 in 2033 under the proposal, which offers the political benefit of not antagonising any current adults. Older citizens would still be able …
Outcomes, infectiousness, and transmission dynamics of patients with extensively drug-resistant tuberculosis and home-discharged patients with programmatically incurable tuberculosis: a prospective cohort study
Authors: Keertan Dheda, Jason D Limberis, Elize Pietersen, Jody Phelan, Aliasgar Esmail, Maia Lesosky, Kevin P Fennelly, Julian te Riele, Barbara Mastrapa, Elizabeth M Streicher, Tania Dolby, Abdallah M Abdallah, Fathia Ben-Rached, John Simpson, Liezel Smith, Tawanda Gumbo, Paul van Helden, Frederick A Sirgel, Ruth McNerney, Grant Theron, Arnab Pain, Taane G Clark, Robin M Warren
Journal: The Lancet Respiratory Medicine (2017)
T-Cell Development Failure At β-Selection Checkpoint and TCRα/δ Locus Break Formation Associated with Chromosome 14 Translocation in Ataxia-Telangiectagia Mutated Deficient Mice
Authors: Takeshi Isoda, Masatoshi Takagi, Jinhua Piao, Shun Nakagama, Masaki Sato, Kyoko Masuda, Tomokatsu Ikawa, Miyuki Azuma, Tomohiro Morio, Hiroshi Kawamoto, Shuki Mizutani
Journal: Blood (2011)
AT9283, a Potent Inhibitor of JAK2, Is Active in JAK2 V617F Myeloproliferative Disease Models.
Authors: Matthew S. Squires, Jayne E. Curry, Mark A. Dawson, Mike A. Scott, Kelly Barber, Matthias Reule, Tomoko Smyth, Nicola Wallis, Murray Yule, Neil T. Thompson, John F. Lyons, Anthony R. Green
Journal: Blood (2007)
MLL Translocation in a Multipotent Progenitor Causing Acute Lymphoblastic Leukaemia - Two-Step Model of the Disease.
Authors: Jan Zuna, Tatiana Burjanivova, Zuzana Zemanova, Sharon Horsley, Lyndal Kearney, Katerina Muzikova, Claus Meyer, Ester Mejstrikova, Alena Houdkova, Hana Ptoszkova, Jan Stary, Melvyn F. Greaves, Jan Trka
Journal: Blood (2006)