tbuckley/cabot-search huggingface dataset:
Pharmacokinetics of desipramine in Caucasian and Asian volunteers
Authors: E H Pi, G H Simpson, T B Cooper
Journal: American Journal of Psychiatry (1986)

The plasma levels of 20 healthy Asian subjects who received a single dose of desipramine were compared with those of 20 healthy Caucasian subjects who received such a dose. The groups differed significantly only in that Asian subjects had an earlier time of peak serum concentration.
THU0110 Work Producivity in Rheumatoid Arthritis: Analysis from Multicenter Turkish Study: Table 1.
Authors: O.N. Pamuk, P. Cetin, D. Solmaz, I. Ertenli, S. Akar, Y. Karaaslan, R.A. Sari, K. Aksu, P. Atagunduz, T. Senturk, A. Cefle, V. Cobankara, S. Kobak, S.S. Koca, Y. Pehlivan, A. Tufan, L. Akyol, K. Gok, O. Kucuksahin, S. Donmez, N. Akkoc
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) is associated with a high disease burden and productivity loss due to joint damage and severe functional disability. There is only limited data on productivity loss in Turkish patients with RA. <h3>Objectives</h3> RA patients from 19 centers across Turkey underwent physical examination and completed questionnaires for global scales, HAQ-DI, EQ5D and WPS-RA. Student9s t test and chi square analysis was used to compare variables. Factors associated with work productivity loss were analyzed by regression analysis. <h3>Methods</h3> RA patients from 19 centers across Turkey underwent physical examination and completed questionnaires for global scales, HAQ-DI, EQ5D and WPS-RA. Student9s t test and chi square analysis was used to compare variables. Factors associated with work productivity loss were analyzed by regression analysis. <h3>Results</h3> 442 patients were enrolled (357 females, mean age: 51.7 years, mean disease duration 9.5 years). 91 patients (22.3%) were employed outside home. Non-working patients were older (44 vs 41, p&lt;0.001), more likely to be female (87.1% vs 58.5%, p: &lt;0.001). Of the remaining patients, 4.9% were unable to work due to arthritis.DMARD and biologic usage were similar in both groups (93.9% vs 95.9% and 37.4% vs 44.8%, respectively). Other features are summarized in Table below. Absenteeism and presenteeism were reported by the 23.7% and 37.6% of the patients, respectively. Higher swollen and tender joint counts,global scores and DAS28-ESR were associated with absenteeism in univariate analysis (p&lt;0.01). Also biologic usage and lower HAQ score were related to less abstenteeism (p&lt;0.05). In multivariate analysis, higher HAQ score (OR: 7.45, 95%CI: 1.26-44.1, p=0.027) was an independent factor for absenteeism. When assessing all RA patients, higher HAQ-DI score was associated with greater household activity impairment score in multivariate analysis (OR: 2.39, 95%CI: 1.77-3, p=0.001). <h3>Conclusions</h3> RA has a major impact on productivity at home and at work. Higher disability score is an independent factor for both absenteeism and household activity impairment. <h3>Acknowledgements</h3> This study was supported by an unrestricted financial grant from UCB. <h3>Disclosure of Interest</h3> None declared
Metabolic Skeletal Superscan on 18F-FDG PET/CT in a Case of Acute Lymphoblastic Leukemia
Authors: Girish Kumar Parida, Ramya Soundararajan, Averilicia Passah, Chandrasekhar Bal, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2015)

Superscan is a well-known finding described in skeletal scintigraphy characterized by intense radiotracer uptake in axial skeleton and decreased uptake in soft tissues and kidneys. Metabolic skeletal superscan has also been described in 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) in various conditions. We describe here a case of 12-year-old boy who presented with a scalp swelling, progressive pallor, easy fatigability, poor appetite, and fever for 6 months. The initial diagnosis was inconclusive. 18F-FDG PET/CT revealed metabolic skeletal superscan and the final histopathological diagnosis was acute lymphoblastic leukemia.
Abrogation of Antitumor Effects of Corynebacterium parvum and BeG by Antimacrophage Agents: Brief Communication 2
Authors: R. Keller
Journal: JNCI Journal of the National Cancer Institute (1977)

The consistently demonstrable antitumor effect of Corynebacterium parvum and BCG against a 7,12-dimethylbenz[a]anthracene-induced rat fibrosarcoma, growing either as a localized subcutaneous tumor or in ascites form, was abrogated by treatment of rats with antimacrophage agents such as silica or carrageena.
Communicable disease epidemiology training in Northern Europe
Authors: P Aavitsland, S Andresen
Journal: Eurosurveillance (2001)

The five Nordic countries (Denmark, Finland, Iceland, Norway and Sweden) have a long tradition of collaboration in communicable disease epidemiology and control. The state epidemiologists and the immunisation programme managers have met regularly to discuss common challenges and exchange experiences in surveillance and control of communicable diseases. After the three Baltic countries (Estonia, Latvia and Lithuania) regained independence in 1991 and the Soviet Union dissolved, contacts were made across the old iron curtain in several areas, such as culture, education, business, military and medicine. Each of the Nordic communicable disease surveillance institutes started projects with partners in Estonia, Latvia, Lithuania or the Russian Federation. The projects were in such diverse areas as HIV surveillance and prevention, vaccination programmes and antibiotic resistance.
AB1090 Comparison of Ultrasonographic Joint and Tendon Findings Between Treatment-Naïve Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
Authors: T. Ogura, A. Hirata, N. Hayashi, H. Ito, S. Takenaka, K. Mizushina, S. Nakahashi, Y. Fujisawa, M. Imamura, H. Kameda
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Although both systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) may lead to the joint deformity, lupus arthritis is typically non-erosive and often accompanied by Jaccoud9s deformity. Therefore, we examined characteristics of joint and tendon lesions in treatment-naïve patients with SLE and RA by using ultrasonography. <h3>Methods</h3> Thirteen treatment-naïve patients with SLE and 39 treatment-naïve RA patients with joint symptoms were included in this study. The hand joints and related tendons were ultrasonographically examined. Their joints and tendons including tendon sheaths were evaluated using a gray-scale (GS) and power Doppler (PD) to a semiquantitative method based on a scale of grades 0 to 3, and the joints or tendons graded as GS ≥2 or PD ≥1 were judged as having joint synovitis and or tendinitis/tenosynovitis. <h3>Results</h3> Joint synovitis was observed in 11 of 13 (85%) and 37 of 39 (95%) patients with SLE and RA, respectively, while tendinitis/tenosynovitis were observed in 12 (92%) and 25 (64%) patients with SLE and RA, respectively. SLE patients had tendinitis/tenosynovitis in the wrist joints more frequently (77% versus 36%, p=0.023) as compared with RA. Although the joint synovitis score (GS+PD) per each affected joint was lower in SLE than RA (2.2 versus 2.8, p=0.019), the tendinitis/tenosynovitis showed comparable scores between SLE and RA (1.3 versus 1.0, p=0.446; Figure 1). In addition, the concordance of joint synovitis and tendinitis/tenosynovitis in the same region was less in SLE patients (κ=0.21) as compared with RA (κ=0.43). <h3>Conclusions</h3> SLE arthropathy is characterized by the relative predominance of tenosynovitis as compared with RA. In addition, tenosynovitis in SLE may develop rather independently from joint synovitis. <h3>Disclosure of Interest</h3> None declared
Esophageal involvement by pemphigus vulgaris resulting in dysphagia
Authors: Paolo Cecinato, Liboria Laterza, Loredana De Marco, Annamaria Casali, Magda Zanelli, Romano Sassatelli
Journal: Endoscopy (2015)

A 44-year-old man was admitted to our institution because of the appearance of painful cutaneous, oral, and genital vesicles. His previous medical history was unremarkable. He had had pharyngitis treated with amoxicillin 1 month before the hospitalization. On physical examination, symmetrically erythematous plaques, covered with vesicles, were seen. Because of subsequent dysphagia for solid food, he underwent esophagogastroduodenoscopy.
Initial Experience of 18F-FDG PET/MRI in Thymic Epithelial Tumors
Authors: Geewon Lee, Hoseok I, Seong-Jang Kim, Kyoungjune Pak, Jeong Su Cho, Yeon Joo Jeong, Chang Hun Lee, Samuel Chang
Journal: Clinical Nuclear Medicine (2015)

The aim of this study was to investigate the value of morphologic, functional, and metabolic biomarkers acquired concurrently at PET/MRI in patients with thymic epithelial tumors.During 1 year, 9 patients with suspected thymic epithelial tumors at contrast-enhanced chest CT were prospectively enrolled and underwent preoperative 18F-FDG PET/MRI. Two chest radiologists prospectively reviewed the CT and MRI scans of PET/MRI in consensus, and 2 nuclear physicians reviewed the PET images. Visual assessment of the tumor morphology, functional biomarkers such as apparent diffusion coefficient from diffusion-weighted images, and metabolic biomarkers (including SUVmax, metabolic tumor volume, total lesion glycolysis, and heterogeneity index) were recorded. All patients underwent operation, and their pathologic reports served as the reference standard.Thymic epithelial tumors were demonstrated in all 9 patients at pathologic examination. Tumor contour (P = 0.012) and shape (P = 0.033) had an association with the World Health Organization subtype, and the presence of septum (P = 0.048) on MRI scans had an association with the Masaoka stage. In terms of functional and metabolic biomarkers, SUVmax (ρ = 0.683, P = 0.042) and SUV/apparent diffusion coefficient (ρ = 0.703, P = 0.035) correlated with the Masaoka stage. Metabolic tumor volume (P = 0.024), heterogeneity index (P = 0.024), and total lesion glycolysis (P = 0.048) were useful for classification between low- and high-risk thymic epithelial tumors.Although limited by the small number of patients enrolled, morphologic, functional, and metabolic biomarkers derived from PET/MRI scans were useful for the stratification of thymic epithelial tumors.
Molecular functions of the transcription factors E2A and E2-2 in controlling germinal center B cell and plasma cell development
Authors: Miriam Wöhner, Hiromi Tagoh, Ivan Bilic, Markus Jaritz, Daniela Kostanova Poliakova, Maria Fischer, Meinrad Busslinger
Journal: The Journal of Experimental Medicine (2016)

E2A is an essential regulator of early B cell development. Here, we have demonstrated that E2A together with E2-2 controlled germinal center (GC) B cell and plasma cell development. As shown by the identification of regulated E2A,E2-2 target genes in activated B cells, these E-proteins directly activated genes with important functions in GC B cells and plasma cells by inducing and maintaining DNase I hypersensitive sites. Through binding to multiple enhancers in the Igh 3′ regulatory region and Aicda locus, E-proteins regulated class switch recombination by inducing both Igh germline transcription and AID expression. By regulating 3′ Igk and Igh enhancers and a distal element at the Prdm1 (Blimp1) locus, E-proteins contributed to Igk, Igh, and Prdm1 activation in plasmablasts. Together, these data identified E2A and E2-2 as central regulators of B cell immunity.
Mammary Carcinogenesis by 3-Methylcholanthrene. II. Inhibitory Effect of Pregnancy and Lactation on Tumor Induction&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: T L DAO, F G BOCK, M J GREINER
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Mammary Carcinogenesis by 3-Methylcholanthrene. II. Inhibitory Effect of Pregnancy and Lactation on Tumor Induction Get access Thomas L. Dao, Thomas L. Dao Roswell Park Memorial Institute, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Fred G. Bock, Fred G. Bock Roswell Park Memorial Institute, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary J. Greiner Mary J. Greiner Roswell Park Memorial Institute, Buffalo, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 25, Issue 5, November 1960, Pages 991–1003, https://doi.org/10.1093/jnci/25.5.991 Published: 01 November 1960 Article history Received: 25 April 1960 Published: 01 November 1960
SP0020 Rheumatology Specialty Training in Europe – The Perspective of UEMS Section of Rheumatology and European Board of Rheumatology
Authors: N. Cikes
Journal: Annals of the Rheumatic Diseases (2015)

Training Requirements for the Specialty Rheumatology - European Standards of Postgraduate Specialty Training was endorsed by UEMS in 2014. The document describes the training requirements for trainee (content of training with learning outcomes and organisation of training), training requirements for trainer (process of recognition of trainer and quality management for trainers), training requirements for institutions (process of recognition of training centre and quality management within training institution); the proposed record of clinical work and list of conditions are included. Based on the training requirements, assessments of knowledge, skills and professional behaviour is needed. Progressively, the common approach to determining whether an individual is suitable to be recognised as a European Rheumatologist is expected. In order to develop the assessment strategy it was agreed that a discussion of how best to ensure that a trainee meets the outcomes of the Training Requirements will be organised. The questionnaire is being developed seeking for the information on the record of clinical work and clinical skills, that exists in many European countries. Within the set of questions it is asked how is the trainee9s knowledge examined, how a trainee9s involvement with the care of patients is determined, how is the competency in a range of clinical procedures assessed, which topics related to professional behaviours are in use and how they are assessed, which evidence of a doctor9s good standing are provided. The answers from the countries9 representatives and a follow-up questionnaire would allow the Section and Board to develop an agreed way in which European trainees might be assessed. <h3>Disclosure of Interest</h3> None declared
The CD4 Cell Dependency of SJL/J B-Cell Lymphomas as a Target for Cyclophosphamide Therapy
Authors: Gerald R. Thrush, Janice L. Placey, Fredrick A. Valeriote, Stephen P. Lerman
Journal: Cancer Communications (1989)

SJL/J B-cell lymphomas induce proliferation of syngeneic CD4 cells, on which the tumors are dependent for growth. We sought to determine whether cyclophosphamide (CY) treatment of tumor-bearing mice would be successful through effects on tumor cells, CD4 cells, or both. The markedly increased survival of treated mice derived predominantly from reduced proliferation of CD4 cells in response to tumor. Reduced proliferation of CD4 cells created a microenvironment that was not conducive to tumor growth, as evidenced by the failure of a subsequent tumor cell challenge to treated mice to significantly increase the rate of the mice. We concluded that CY affected the tumor-stimulated environment of SJL/J mice by killing CD4 cells that had been activated by a pre-existing tumor stimulus and by promoting the appearance of a population of CD8 cells that suppressed the ability of residual or recovering CD4 cells to proliferate in response to tumor. The CD8 population from treated mice was specific, based on the ability to suppress a tumor-stimulated mixed lymphocyte response (MLR) and the related autologous MLR and an inability to suppress an allogeneic- or Con A-induced response. Since CD8 cells from CY treated mice had no demonstrable antitumor activity, the most likely suppressor targets were responder CD4 cells in the tumor-stimulated MLR. The results emphasize that the design of a treatment protocol can take advantage of the immunodependency of a tumor.
June 10, 1912: A Discussion on Syphilis, with Special Reference to (A) Its Prevalence and Intensity in the Past and at the Present Day; (B) Its Relation to Public Health, Including Congenital Syphilis; (C) the Treatment of the Disease: Opening Address, with special reference to the Relation of the Disease to Public Health, including Congenital Syphilis
Authors: F. W. Mott
Journal: Journal of the Royal Society of Medicine (1912)
Hair Dye Use and Breast Cancer
Authors: K L Koenig, B S Pasternack, R E Shore
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Hair Dye Use and Breast Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 72, Issue 6, June 1984, Page 1211, https://doi.org/10.1093/jnci/72.6.1211 Published: 01 June 1984
Effects of recombinant human G-CSF, GM-CSF, IL-3, and IL-1 alpha on the growth of purified human peripheral blood progenitors
Authors: Y Takaue, Y Kawano, CL Reading, T Watanabe, T Abe, T Ninomiya, E Shimizu, T Ogura, Y Kuroda, A Yokobayashi
Journal: Blood (1990)
PTH-275 Restaging after neoadjuvant chemoradiation in rectal cancers – is histology the key in patient selection?
Authors: KC Vallam, N Singhal, S Arya, R Engineer, V Ostwal, A Saklani
Journal: Gut (2015)

<h3>Introduction</h3> Neoadjuvant chemoradiation is the standard of care for locally advanced rectal cancer. However, there is no clarity regarding the necessity for restaging scans to rule out systemic progression of disease post chemoradiation with existing literature being divided on the need for the same. <h3>Method</h3> Data from a prospectively maintained database was retrospectively analysed. All locally advanced rectal cancers (Node positive/T4/T3 with threatened or involved CRM) were included. Biopsy proof of adenocarcinoma and CT scan of abdomen and chest were mandatory for inclusion. Grade of tumour and response to chemoradiation (CTRT) on restaging MRI were documented. <h3>Results</h3> Out of 119 patients subjected to CTRT, 72 underwent definitive total mesorectal excision while 13 patients progressed locoregionally on restaging MR pelvis and 15 other patients progressed systemically while 15 patients defaulted and 4 patients did not complete radiation. Patients with poorly differentiated (PD) cancers were compared to those with well/moderately differentiated (WMD) tumours. PD tumours had a significantly higher rate of local progression (32.1% vs. 5.6%%, p = 0.0011) and systemic progression (35.7% vs. 6.9%, p = 0.0008) as compared to WMD tumours. Only one-third (9/28) of PD patients underwent TME while the rest progressed. <h3>Conclusion</h3> Selecting poorly differentiated tumours alone for restaging CECT abdomen and thorax will be a cost effective strategy as the rate of progression is very high. Also patients with PD tumours need to be counselled about the high probability of progression of disease. <h3>Disclosure of interest</h3> None Declared.
A non-invasive liquid biopsy approach for therapeutic stratification of lung cancer patients.
Authors: Hatim Husain, Jillian Phallen, Sonya Parpart-Li, Derek M Murphy, Vilmos Adleff, Samuel V. Angiuoli, Siân Jones, Ezra E. W. Cohen, Scott Michael Lippman, Luis A. Diaz, Mark Sausen, Razelle Kurzrock, Victor E Velculescu
Journal: Journal of Clinical Oncology (2015)

e19082 Background: Liquid biopsies of circulating tumor DNA (ctDNA) may eliminate the need for invasive tissue biopsies and allow the detection of alterations in multiple metastatic lesions throughout the course of therapy. This is of particular importance in lung cancer, where a third of patients may have insufficient biopsies for molecular analyses and may be ineligible for approved targeted therapies. However, the fraction of ctDNA obtained from a blood sample is often low ( < 1.0%) and can be difficult to detect with current approaches. Additionally, most methods to detect ctDNA interrogate single hot spot mutations or a few genetic alterations. Methods: To overcome these issues, we developed comprehensive ctDNA approaches to detect somatic sequence mutations, translocations, and amplifications at low allele frequencies in the circulation of cancer patients. These analyses span 63 well-established cancer genes, including BRAF, EGFR, ERBB2, PI3KCA, FGFR, KRAS and NRAS, translocations in ALK, EGFR, NTRK1, RET and ROS1, and amplification of MET and ERBB2. This comprehensive panel covers many recognized resistance mechanisms to targeted therapies and provides a method to understand patterns of intrinsic and acquired resistance in oncogene defined lung cancer. To evaluate this approach, we performed dilution series using tumor-derived DNA, containing well-characterized somatic mutations, in the presence of wild-type DNA in 3-5ml of plasma from 90 patients with late-stage lung cancer. Results: We were able to detect sequence alterations at levels of > 0.01% with a specificity of > 99.9%. Further analyses demonstrated high concordance between the somatic sequence mutations and translocations identified in the tumor sample and those identified in the plasma, including alterations in driver genes as well as those related to acquired resistance to targeted therapies. 70 patients had serial samples, and within this cohort, we demonstrated evolution of resistance clones that predict radiographic increases in tumor burden. Conclusions: These analyses provide a non-invasive platform to enable liquid biopsy detection of clinically relevant genetic alterations across a large number of genomic loci in lung cancer patients.
Total Anomalous Pulmonary Venous Drainage
Authors: A K Airede
Journal: JAMA (1963)

A case of a Nigerian full-term infant with complete anomalous pulmonary venous drainage into the coronary sinus is described. Presentation was from birth but the cardiac defect was clinically suspected at the age of 51 hours. Diagnosis was confirmed by two-dimensional echocardiography and cardiac catheterization. Despite a high operative mortality associated with this condition, the infant had a remarkably smooth post operative course and an excellent result from his repair on the 5th day of his life.
&lt;italic&gt;p&lt;/italic&gt;CO&lt;sub&gt;2&lt;/sub&gt; Inhibition of Normal and Malignant Growth&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: W F LOOMIS
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article pCO2 Inhibition of Normal and Malignant Growth Get access W. F. Loomis, M.D. W. F. Loomis, M.D. The Loomis Laboratory, Greenwich, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 22, Issue 2, February 1959, Pages 207–217, https://doi.org/10.1093/jnci/22.2.207 Published: 01 February 1959 Article history Received: 17 September 1958 Published: 01 February 1959