tbuckley/cabot-search huggingface dataset:
FRI0181 Change from SC to IV Abatacept and Back in Patients with Rheumatoid Arthritis as Simulation of a Vacation: A Prospective Phase IV, Open Label Trial (A-Break)
Authors: R. Mueller, M. Gengenbacher, S. Richter, J. Dudler, B. Möller, J. von Kempis
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Holiday seasons can present a major problem to RA patients treated with weekly subcutaneous biologics, including subcutaneous (SC) abatacept. Therefore an evaluation into the use of IV-abatacept treatment to cover a 4 week break may present an acceptable alternative. <h3>Objectives</h3> To study the efficacy and safety of a single intravenous (IV) course with abatacept in Patients with rheumatoid arthritis currently receiving weekly injections of SC abatacept to simulate a patient "vacation" followed by a switch back to SC abatacept. <h3>Methods</h3> This open label, prospective, single arm 24-weeks trial recruited patients with established RA and in low disease activity (LDA) under treatment with SC abatacept for at least 3 months to receive a single dose of IV abatacept (day 0) and to be continued on SC abatacept from day 28 on (NCT01147341). DMARD- and/or biologic-inadequate responders were included and previous exposure to IV abatacept was allowed in a maximum of 50% of the patients. <h3>Results</h3> Baseline characteristics of the 49 patients were typical for a cohort of RA patients with established disease (mean disease duration 8.31 years) in LDA under treatment. Two patients dropped out of the study (1 flare, 1 patient decision). The proportion of patients with DAS 28 ≤3.2 at day 28 was 93.9% (95%CI 83.5-97.9) at day 28, 91.7% (95%CI 80.4-96.7) at day 84 and 93.6 (95%CI 82.8-97.8) at the end of the study, day 168. This proportion remained stable throughout the entire follow up. The average DAS 28 at baseline was 1.74 (SD ±0.72) at baseline, 2.03 (SD ±1.03) at day 28, 1.86 (SD ±0.91) at day 84 and 1.96 (SD ±0.92) at the end of the study, day 168. Pre-exposure to IV abatacept and having failed MTX or anti TNF did not influence the average DAS 28 or the proportion of patients maintaining LDA. The average HAQ-DI was stable throughout the study. Adverse events occurred in 75% of subjects. Four serious adverse events (SAE) were described during the study. None of them was related to the investigational product and all SAE could be resolved during hospitalization. Discontinuation of abatacept was not necessary in these patients. There were no deaths, neoplasms, opportunistic or other serious infections. <h3>Conclusions</h3> This prospective, open label study of abatacept shows for the first time that switching from weekly SC to IV abatacept and back after 4 weeks is an effective and safe way to bridge holidays in RA patients in LDA. <h3>Disclosure of Interest</h3> R. Mueller Grant/research support from: The study was supported by an unrestricted research grant from BMS, M. Gengenbacher: None declared, S. Richter: None declared, J. Dudler: None declared, B. Möller: None declared, J. von Kempis Grant/research support from: The study was supported by an unrestricted research grant from BMS
AB0894 Hight Resolution Consultation of a Bone Metabolism Unit (BMU). First Year Results: Table 1
Authors: E. Chamizo, L.M. Mellado, S.M. Rojas, R. Veroz, T.L. Rodríguez Araya, J.J. Aznar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteoporosis (OP) is a silent disease until fractures appear. The controversy in diagnosis and treatment results in a variability in the management and a high frequency in consultation. In 2013 we started in collaboration with Primary Care (PC) a high resolution consultation to unify the management of OP in Merida and the surrounding area in the west of Spain. <h3>Objectives</h3> Describe the characteristics of the population attended during the first year in the high resolution consultation of OP, from July 2013 to June 2014. <h3>Methods</h3> We systematically collect the data of the interview oriented by clinical risk factors of OP, calculation of fracture risk (FRAX) before and after of the Bone Mineral Densitometry (BMD), blood analysis with levels of vitamin D, lumbar spineBMD (L2-L4) and hipBMD (femoral neck), lateral radiography of dorsolumbar spine and treatment, all performed in the same visit. <h3>Results</h3> 355 patients were attended to with a mean age of 64.13 years old (95%CI 62.89; 65.37), coming from PC 277 (78%), and Specialized Care (SC) 78 (22%), mainly Oncology (23) with suspicion of OP. The characteristics of the population can be seen in the figure 1. Of the 277 patients coming from PC, 104 were treated for OP (mainly with biphosphonates) and 67 hadn9t been diagnosed with OP. In the evaluation we detected fractures in 15 patients and FRAX- hipBMD&gt;3 in 17 patients and 46 patients didn9t need treatment because they were found not to have OP. The other 172 patients hadn9t received any previous treatment, 4 of them had diagnosis of OP (previous BMD) and 2 had one fracture. After the study, we detected a FRAX-hipBMD&gt;3 in 32 patients and we started immediatly treatment in 53 patients. <h3>Conclusions</h3> High resolution consultation of OP has improved the accessibility of the patients from PC, has decreased the number of displacements and the number of consultations because the all the procedures are done on the same day. The systematic use of the clinical risk factors and the BMD helps practitioners decrease the variability in the diagnosis and treatment as shows the interruption of 43 treatment and the establishment of 53. <h3>Disclosure of Interest</h3> None declared
Increasing multidrug resistance and limited treatment options: situation and initiatives in Europe
Authors: K G Kristinsson, D L Monnet
Journal: Eurosurveillance (2008)

Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for decades. In 2001, European Union Ministers of Health adopted Council Recommendations on the prudent use of antimicrobial agents in human medicine. This issue of Eurosurveillance is the second one this month dedicated to antimicrobial resistance, in connection with the first-ever European Antibiotic Awareness Day - a European Union (EU) health initiative involving all key players to increase awareness of Europeans about antimicrobial resistance and prudent use of antibiotics.
Hemostatic Clip in Gastrointestinal Bleeding
Authors: N Soehendra, P V Sriram, T Ponchon, S C Chung
Journal: Endoscopy (2001)

Gastrointestinal bleeding is one of the most common emergencies in gastroenterology practice. In about 90% of patients, the source of bleeding is localized to the upper gastrointestinal tract, in 9% to the colon, and in 1 % to the small bowel. Thus most lesions are accessible for endoscopic treatment. Amongst the common causes of severe upper gastrointestinal bleeding, gastroduodenal ulcers and esophageal varices are the leading ones. Less common causes include Mallory-Weiss tears, Dieulafoy lesions, angiomas, and antral vascular ectasia, etc. In the lower gastrointestinal tract, hemorrhoids, colonic diverticula, arteriovenous malformations, polypectomy, and, rarely, rectal injuries can induce severe bleeding. On the other hand, acute bleeding from polyps and tumors is rare. Most lesions located in the upper and lower gastrointestinal tract are accessible for endoscopic treatment. The different endoscopic hemostatic methods available include injection (using sclerosants like polidocanol, ethanolamine, alcohol, hypertonic saline, etc., or nonsclerosing substances like diluted epinephrine), thermal treatment (heater probe, monopolar or multipolar electrocoagulation, laser, argon plasma coagulation, etc.), and more recently mechanical methods (hemoclip, endoloop, and band ligation) [1].
Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice
Authors: X Liu, D M Barrett, S Jiang, C Fang, M Kalos, S A Grupp, C H June, Y Zhao
Journal: Blood Cancer Journal (2016)

Despite the impressive clinical efficacy of T cells engineered to express chimeric antigen receptors (CAR-Ts), the current applications of CAR-T cell therapy are limited by major treatment-related toxicity. Thus, safer yet effective alternative approaches must be developed. In this study, we compared CD19 bispecific T-cell engager (BiTE)-transferred T cells that had been transfected by RNA electroporation with CD19 CAR RNA-transferred T cells both in vitro and in an aggressive Nalm6 leukemia mouse model. BiTEs were secreted from the transferred T cells and enabled both the transferred and bystander T cells to specifically recognize CD19(+) cell lines, with increased tumor killing ability, prolonged functional persistence, increased cytokine production and potent proliferation compared with the CAR-T cells. More interestingly, in comparison with CD3/CD28 bead-stimulated T cells, T cells that were expanded by a rapid T-cell expansion protocol (REP) showed enhanced anti-tumor activities for both CAR and BiTE RNA-electroporated T cells both in vitro and in a Nalm6 mouse model (P<0.01). Furthermore, the REP T cells with BiTE RNAs showed greater efficacy in the Nalm6 leukemia model compared with REP T cells with CAR RNA (P<0.05) and resulted in complete leukemia remission.
Symposium on Breast Cancer
Authors: R A MARCIAL ROJAS, V A MARCIAL, P L MORALES, R E LLOBET, L A VALLECILLO
Journal: JNCI Journal of the National Cancer Institute (1975)

Symposium on Breast Cancer Get access JNCI: Journal of the National Cancer Institute, Volume 54, Issue 1, January 1975, Page 284, https://doi.org/10.1093/jnci/54.1.284 Published: 01 January 1975
FRI0230 The Initial Symptoms of Ankylosing Spondylitis and the HLA-B27 Subtypes
Authors: Q. Jun, P. Zhang, Z. Lin, J. Gu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Different subtypes of HLA-B27 have a special positive association with some clinical features of AS.HLA-B*2705-positive patients had a higher incidence of uveitis.however,whether AS patients with different HLA-B27 subtypes have different initial symptoms is not clear. <h3>Objectives</h3> This study aimed to investigate the association between the initial symptoms and the HLA-B27 subtypes. <h3>Methods</h3> This study included 476 patients with AS. Direct sequencing was used to identify the HLA-B27 genotype. Clinical parameters, including initially affected sites, were compared among patients with various HLA-B27 subtypes. <h3>Results</h3> Out of 476 patients, 437 AS patients (91.8%) were HLA-B27-positive. The most prevalent subtypes were HLA-B*2704 (90%) and HLA-B*2705 (8.6%) in patients with AS. Initially affected sites such as axial joint (54.5% and 55.3%) and peripheral joint (35.9% and 31.6%) were most common between HLA-B*2704-positive patients and HLA-B*2705-positive patients. There were no significant differences in initially affected sites such as axial joint, peripheral joint, hip joint, axial joint+ peripheral joint, axial joint+hip, or peripheral joint+ hip among above groups. Compared with HLA-B*2704-positive patients, HLA-B*2705- patients demonstrated a significant increase in the incidence of uveitis (initial symptom, 5.3% vs. 0.5%, P=0.041). <h3>Conclusions</h3> Specific HLA-B27 subtypes were positively associated with particular initial symptoms. Uveitis was more frequent as an initial symptom in HLA-B*2705-positive patients than HLA-B*2704-positive patients did. <h3>References</h3> Qi J, Li Q, Lin Z, et al. Higher risk of uveitis and dactylitis and older age of onset among ankylosing spondylitis patients withHLA-B*2705than patients withHLA-B*2704in the Chinese population. Tissue antigens. 2013;82(6):380-386 Braakenburg AM, de Valk HW, de Boer J, Rothova A. Human leukocyte antigen-B27-associated uveitis: long-term follow-up and gender differences. Am J Ophthalmol 2008: 145: 472–9. <h3>Disclosure of Interest</h3> None declared
Reduced length and cost of hospital stay for major depression in patients treated with ECT
Authors: J Markowitz, R Brown, J Sweeney, J J Mann
Journal: American Journal of Psychiatry (1987)

To investigate the effect of treatment modality on length of hospital stay, the authors retrospectively studied 86 admissions of 74 patients with major depression. All 19 patients who received ECT recovered, in contrast to only 27 (49%) of 55 patients given tricyclic antidepressants or other medication. The 28 patients who had not responded to antidepressants recovered after treatment with ECT. Treatment modality had a highly significant effect on length of hospital stay: patients given ECT stayed a mean of 13 fewer days, saving more than $6,400 per patient at current rates. These findings of significant economic and therapeutic benefits in the use of ECT raise issues about treatment selection for depressed inpatients.
SURGICAL ASPECTS OF HISTOPLASMOSIS
Authors: N T GRISCOM
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Research in Developing Countries
Authors: Steven D Schwaitzberg
Journal: New England Journal of Medicine (2002)

These guidelines for rapid reconnaissance have evolved out of my work on food systems and agricultural marketing with Michigan State University and USAID over the past eight years.As a doctoral candidate at Michigan State, I conducted studies of livestock and food systems in Cameroon and Somalia 1 using both rapid appraisal methods and longitudinal, cost-route formal surveys.Upon
National outbreak of Salmonella Java phage type 3b variant 9 infection using parallel case–control and case–case study designs, United Kingdom, July to October 2010
Authors: M Gobin, N Launders, C Lane, G Kafatos, B Adak
Journal: Eurosurveillance (2011)

Between July and October 2010, a national outbreak comprising 136 cases of Salmonella Java phage type 3b variant 9 was identified by the Health Protection Agency. Most cases were female. Cases had a median age of 39.5 years and lived in London, the South East and East of England. Parallel case–control and case–case study designs were undertaken to test the generated hypotheses. The case–case study aimed to examine if the infection was associated with eating food items purchased from commercial catering settings, and the reference group comprised non-travel related cases of S. Enteritidis infected during the same time period as the cases. The case–control study was designed to examine if the infection was associated with specific food items purchased from commercial catering settings, and recruited case-nominated controls. However, in response to poor recruitment we adapted our methods to investigate food exposures in the same way. Results of epidemiological investigations are compatible with salad vegetables as the potential source, but no common suppliers of salad were identified and no organisms were isolated from environmental and food samples. Limitations in the case–control study highlight the potential value of using a combination of epidemiological methods to investigate outbreaks.
Underground Mining, Smoking, and Lung Cancer
Authors: Archer, Victor E.
Journal: JNCI Journal of the National Cancer Institute (1986)

Journal Article Underground Mining, Smoking, and Lung Cancer Get access Victor E. Archer, M.D. Victor E. Archer, M.D. Rocky Mountain Center for Occupational and Environmental Health, Building 512, University of Utah Medical Center, Salt Lake City, Utah 84112 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 76, Issue 3, March 1986, Page 553, https://doi.org/10.1093/jnci/76.3.553 Published: 01 March 1986
PWE-020 Endoscopically applied intra-rectal formalin for radiation proctopathy: short and longer term outcomes
Authors: K Klimova, M Khan, A Muls, H Alexander, H Jolly, J Andreyev
Journal: Gut (2015)

STUDY OBJECTIVE--The aim was to survey oral contraceptive usage among women under 25 years of age. DESIGN--This was a cross sectional population study based on information collected by questionnaire mailed to randomly selected individuals. SETTING--The study population consisted of Swedish women born between 1960 and 1964 and living in the southern Swedish health care region which has about one and a half million inhabitants. PARTICIPANTS--The sample consisted of 3477 women, of whom 2573 or 74% agreed to participate in the study and were interviewed between November 1990 and April 1991. MAIN RESULTS--Of the 2573 women participating, 2254 (88%) reported having used oral contraceptives at some time, 77% of them having started during their teens. Teenage start of oral contraceptive use was found to be related to a lower age at menarche, a higher marriage/cohabitation rate, a lower rate of teenage full term pregnancy, a higher rate of spontaneous abortion, a lower frequency of teetotalism, and a higher frequency of smoking. Longterm use of antipsychotic drugs appeared to be less common among women who started oral contraceptive use early, but no relationship with other pharmaceutical drug usage was found. No relationship was found between oral contraceptive use and the presence of a first degree relative with cancer. CONCLUSIONS--A large proportion of Swedish women start using oral contraceptives during their teens, and report long duration of usage both before their first full term pregnancy and before the age of 25 years. The few women who have never used oral contraceptives do not appear to be representative of the general population.
Chickenpox
Authors: Sharon Parmet
Journal: JAMA (2004)

Chickenpox Chickenpox is a highly contagious and common childhood disease caused by a virus in the herpes family of viruses called the varicella virus.The varicella virus can remain in the body for decades and become active again in adults, causing herpes zoster (shingles).Shingles involves the occurrence of painful skin sores along the distribution of nerves across the trunk or face.The February 18, 2004, issue of JAMA includes an article about the effectiveness of the varicella vaccine in preventing chickenpox.
Consumers' views of DSM-III: attitudes and practices of U.S. psychiatrists and 1984 graduating psychiatric residents
Authors: V C Jampala, F S Sierles, M A Taylor
Journal: American Journal of Psychiatry (1986)

The authors surveyed U.S. psychiatrists and psychiatric residents graduating in 1984 about their use and views of DSM-III. Although the majority approved of DSM-III generally, 35% of the psychiatrists and 20% of the residents said they would stop using it if it were not required. Residents accepted DSM-III better than did practicing psychiatrists. Many of the respondents doubted the validity of some diagnoses and stated that many of their patients did not satisfy criteria needed for the DSM-III diagnoses in their records. Most respondents did not use all DSM-III axes and did not want new axes. The authors discuss the survey results and their implications for revision of DSM-III.
Head Injury
Authors: Janet M. Torpy
Journal: JAMA (2005)

Computed tomographic (CT) scan tests use high-speed x-rays.CT images can show swelling, bleeding, or compression of brain tissue.• Magnetic resonance imaging (MRI) tests use magnetic energy to produce detailed images of brain tissue, bones, and other structures.• Oxygen may be given by mask, nasal tubing, or ventilator (breathing machine).Individuals who are unconscious (comatose) may require a ventilator to breathe for them.• Medicines to prevent or treat seizures, decrease brain swelling, control agitation, or control blood pressure may be given to patients with brain injury.The more severe the injury, the more medications and treatments are required.• Hypothermia (lowered body temperature) has been shown in some medical studies to help improve recovery after a severe traumatic brain injury.This must be done as part of intensive care for a severe brain injury and must be carefully monitored.Further research is required to determine the effectiveness of this treatment.• After the acute phase (first part) of care for the injury, persons with traumatic brain injury often receive intensive rehabilitation to maximize their functional level (what they are able to do) and improve their overall recovery.
Severe chronic primary neutropenia in adults: report on a series of 108 patients
Authors: Flore Sicre de Fontbrune, Aline Moignet, Blandine Beaupain, Felipe Suarez, Lionel Galicier, Gérard Socié, Bruno Varet, Paul Coppo, Marc Michel, Cécile Pautas, Eric Oksenhendler, Etienne Lengline, Louis Terriou, Philippe Moreau, Sylvain Chantepie, Nicole Casadevall, Jean Marie Michot, Martine Gardembas, Mauricette Michallet, Laure Croisille, Marie Audrain, Christine Bellanné-Chantelot, Jean Donadieu, Thierry Lamy
Journal: Blood (2015)