tbuckley/cabot-search huggingface dataset:
Cholinergic regulation of mood and REM sleep: potential model and marker of vulnerability to affective disorder
Authors: N Sitaram, J I Nurnberger, E S Gershon, J C Gillin
Journal: American Journal of Psychiatry (1982)

To test the hypothesis that depression and REM sleep share common cholinergic mechanisms the authors administered arecoline 25 min after completion of the first REM period to 14 patients with remitted bipolar affective disorder, 15 normal controls, and 5 subjects with a personal or family history of affective disorder. The second REM period occurred significantly sooner in the remitted patients than in the normal controls. The patients also had a significantly higher density of eye movements during the first REM period and a higher percentage of REM sleep. The authors believe that increased cholinergic sensitivity and REM density may be biological markers of increased vulnerability to bipolar affective illness.
Campylobacteriosis and other bacterial gastrointestinal diseases in Sofia, Bulgaria for the period 1987 – 2008
Authors: K Ivanova, M Мarinа, P Petrov, T Kantardjiev
Journal: Eurosurveillance (2010)

Campylobacter is the most commonly reported enteric bacterial pathogen in humans. We still do not have any systematic data concerning campylobacteriosis in Bulgaria. For that reason, we present data of the thermophilic Campylobacter jejuni and Campylobacter coli in the aetiology of diarrhoeal diseases in Sofia, for the period from 1987 to 2008. The study included patients from 0 to over 65 years-old. A total of 51,607 faecal specimens were screened for Campylobacter. C. jejuni and C. coli were detected in 3.58% (1,847) of the strains, with the highest percentage in 1988 (7.5%) and the lowest in 2006 (0.3%). Campylobacteriosis occurred most frequently in the wet months of March, April, May and June, with 105, 102, 124 and 141 cases, respectively, and was rare in January with 25 cases. The most affected groups were children between 0 and 4 years of age (52%) and between five and 14 years of age (30%). Campylobacter infection occurred in 22% of all bacterial gastrointestinal diseases in the city of Sofia during the study period. Salmonella was the most frequently identified pathogen with 32%, followed by Shigella (30%), Campylobacter (22%) and diarrhoeagenic Escherichia coli (16%). The study shows that Campylobacter plays an important role as a bacterial cause of enterocolitis in Sofia, Bulgaria.
Underreporting of legionnaires’ disease in France : the case for more active surveillance
Authors: A Infuso, B Hubert, J Etienne
Journal: Eurosurveillance (1998)

In France, surveillance of legionnaires disease started in 1987 with a mandatory clinician-based notification system. An average of 54 cases were reported yearly between 1988 and 1995 and six non-nosocomial clusters were identified. In 1995 the surveilla
Influence of Tube Rotation Velocity on Proliferation of Strain L Cells in Surface Substrate Roller-Tube Cultures&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: W R EARLE, E L SCHILLING, J C BRYANT
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Influence of Tube Rotation Velocity on Proliferation of Strain L Cells in Surface Substrate Roller-Tube Cultures Get access Wilton R. Earle, Wilton R. Earle Tissue Culture Section, Laboratory of Biology, National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Edward L. Schilling, Edward L. Schilling Tissue Culture Section, Laboratory of Biology, National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jay C. Bryant Jay C. Bryant Tissue Culture Section, Laboratory of Biology, National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 4, February 1954, Pages 853–864, https://doi.org/10.1093/jnci/14.4.853 Published: 01 February 1954 Article history Received: 30 July 1953 Published: 01 February 1954
PNR-37GAMMA KNIFE RADIOSURGERY IN THE MANAGEMENT OF DYSEMBRYOPLASTIC NEUROEPITHELIAL TUMORS (DNT): THREE CASES AND REVIEW OF THE LITERATURE
Authors: Georges Sinclair, Jiri Bartek, Heather Martin, Alia Shamikh, Yeah-yeah Al-Saffar, Bengt Gustavsson, Mikael Svensson, Ernest Dodoo
Journal: Neuro-Oncology (2016)

BACKGROUND: Dysembryoplastic neuroepithelial tumors (DNT) have long been regarded as rare benign tumors.Nevertheless, in recent years, different authors have reported cases of much complex nature and unstable evolution.Still, open surgery alone is widely regarded as the only effective treatment.We intend to illustrate DNT's more "entangled" evolution and how gamma knife radiosurgery(GKRS) might be successfully applied in selected cases.CASE SERIES DESCRIPTION: We present three unusual cases of DNT successfully treated by GKRS.Despite the above, the role of GKRS in the management of DNT's remain li-diagnostics aamited, almost unreported.We proceed to review recent medical publications (2009)(2010)(2011)(2012)(2013)(2014)(2015) covering latest developments in DNT-diagnostic and general management.CONCLUSION: In all three cases GKRS proved to be effective in terms of tumor control, seizure freedom and radiation-induced adverse effects.We found only two other cases if DNT's trated by gamma knife in PubMed; both with positive outcome.Studies with larger patient groups are necessary to clarify the role of radiosurgery in the management of DNT's.
The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity
Authors: Elise Jeffery, Allison Wing, Brandon Holtrup, Zachary Sebo, Jennifer L. Kaplan, Rocio Saavedra-Peña, Christopher D. Church, Laura Colman, Ryan Berry, Matthew S. Rodeheffer
Journal: Cell Metabolism (2016)
Carcinogenesis in F344 Rats by &lt;italic&gt;N&lt;/italic&gt;-Nitrosomethyl-&lt;italic&gt;n&lt;/italic&gt;-propylamine Derivatives&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: W Lijinsky, M D Reuber, J E Saavedra, G M Singer
Journal: JNCI Journal of the National Cancer Institute (1983)

The carcinogenicity of N-nitrosomethyl-n-propylamine and five of its derivatives, including N-nitrosomethyl-n-butylamine, was compared by oral administration of the compounds to inbred F344 rats. N-Nitromethyl-n-propylamine and N-nitrosomethyl-n-butylamine given in drinking water induced tumors of the upper gastrointestinal tract, mainly carcinomas of the esophagus, and appeared to be of comparable potency. N-Nitrosomethyl(2-hydroxypropyl)amine also mainly induced esophageal carcinomas (100% incidence) and lung tumors, whereas N-nitrosomethyl(2,3-dihydroxypropyl)amine mainly induced nasal cavity tumors and gave rise to a high incidence of esophageal tumors; however, it appeared to be less potent than the monohydroxy compound. N-Nitrosomethyl(2-oxopropyl)amine, the ketone corresponding to N-nitrosomethyl(2-hydroxypropyl)amine, was a more potent carcinogen than the latter at comparable doses in drinking water and gave rise to a high incidence of esophageal tumors and tumors of the trachea; female rats had a high incidence (15/20) of angiosarcomas of the liver, but only 2 male rats died with this tumor. When N-nitrosomethyl(2-oxopropyl)amine was administered at a lower dose in drinking water or at the same dose given by gavage, the incidence of esophageal tumors was lower and there were fewer carcinomas. After administration of large doses in drinking water to male and female rats, N-nitrosomethyl(3-carboxypropyl)amine, a urinary metabolite of several N-nitrosomethyl-n-alkylamines that induce tumors of the urinary bladder in rats, gave rise to a high incidence of transitional cell carcinomas of the bladder. The time to death of animals with these tumors was long, and there were few other tumors.
Case 44-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Dempsey S. Springfield, Andrew E. Rosenberg
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 69-year-old man was admitted to the hospital because of numbness of the right hand and a mass in the right axilla.He was well until two months earlier, when he began to notice numbness over the palmar aspect of the right thumb and index, middle, and third fingers. Two weeks before admission he felt a right axillary mass and observed that the numbness was increasing and that the flexors of the right thumb, index finger, and wrist were weak. He was seen at another hospital, where examination of a stool specimen for occult blood was reported . . .
Lenalidomide Promotes CRBN-Mediated Ubiquitination and Degradation of IKZF1 and IKZF3
Authors: Jan Krönke, Namrata Udeshi, Anupama Narla, Peter Grauman, Slater Hurst, Marie McConkey, Tanya Svinkina, Dirk Heckl, Eamon Comer, Xiaoyu Li, Christie Ciarlo, Emily Hartman, Monica Schenone, Stuart Schreiber, Steven A. Carr, Benjamin L. Ebert
Journal: Blood (2013)
Surface IgM expression and function are associated with clinical behavior, genetic abnormalities, and DNA methylation in CLL
Authors: Annalisa D’Avola, Samantha Drennan, Ian Tracy, Isla Henderson, Laura Chiecchio, Marta Larrayoz, Matthew Rose-Zerilli, Jonathan Strefford, Christoph Plass, Peter W. Johnson, Andrew J. Steele, Graham Packham, Freda K. Stevenson, Christopher C. Oakes, Francesco Forconi
Journal: Blood (2016)
Simple Hemolysis Test for Classification of Mycobacteria
Authors: K TAKEYA, R MORI, K HISATSUNE, T TODA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PNR-27REOPERATION (GROSS-TOTAL RESECTION) AFTER CHEMOTHERAPY AND RADIOTHERAPY FOR ETANTR: A CASE REPORT AND LITERATURE REVIEW
Authors: Sayaka Nakamura, Yuko Ishii, Yoshiko Nakano, Chika Nitani, Keiko Okada, Hiroyuki Fujisaki, Yuta Nakanishi, Noritsugu Kunihiro, Yasuhiro Matsusaka, Hiroaki Sakamoto, Junichi Hara
Journal: Neuro-Oncology (2016)
HG-02A PHASE 1/2 TRIAL OF THE ANTIBODY PIDILIZUMAB (MDV9300) IN PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA
Authors: Iris Fried, Alex Lossos, Tal BenAmi, Rina Dvir, Helen Toledano, Myriam Ben Arush, Sergei Postovski, Abed AbuKuidar, Michal Yalon, Michael Weintraub
Journal: Neuro-Oncology (2016)
Zika virus infection in a traveller returning from the Maldives, June 2015
Authors: Essi Marjana Korhonen, Eili Huhtamo, Teemu Smura, Hannimari Kallio-Kokko, Markku Raassina, Olli Vapalahti
Journal: Eurosurveillance (2016)

We report a Zika virus (ZIKV) infection in a patient with fever and rash after returning to Finland from Maldives, June 2015. The patient had dengue virus (DENV) IgG and IgM antibodies but pan-flavivirus RT-PCR and subsequent sequencing showed presence of ZIKV RNA in urine. Recent association of ZIKV with microcephaly highlights the need for laboratory differentiation of ZIKV from DENV infection and the circulation of ZIKV in areas outside its currently known distribution range.
B Lymphocytes
Authors: M D Cooper
Journal: New England Journal of Medicine (1987)

B-LINEAGE cells constitute one of the principal limbs of the immune system. Their chief function is to produce antibodies to protein and carbohydrate antigens on microorganisms, toxins, or other antigenic substances potentially harmful to the body. The vast array of antibodies belong to nine different immunoglobulin isotypes (IgM, IgD, IgG1, IgG2, IgG3, IgG4, IgA1, IgA2, and IgE), each of which has a different biologic advantage.1 IgM antibodies, which are made first, are the most efficient in activating the cascade of complement proenzymes, the active elements of which promote . . .
THE GERMICIDAL ACTION OF α-MERCAPTO AND α-DISULFO SOAPS
Authors: Arnold H. Eggerth
Journal: The Journal of Experimental Medicine (1931)

1. Certain of the α-mercapto soaps and α-disulfo soaps are powerful germicides. 2. In the α-mercapto series, those soaps with 12 and 14 carbon atoms are most germicidal. In the disulfo series, the dicaprate, dilaurate, and dimyristate are most germicidal. The optimum number of carbon atoms varies with the test organism used. 3. These soaps, like others previously studied, show a markedly selective germicidal action.
Infection of Nippostrongylus brasiliensis induces development of mucosal-type but not connective tissue-type mast cells in genetically mast cell-deficient Ws/Ws rats
Authors: N Arizono, T Kasugai, M Yamada, M Okada, M Morimoto, H Tei, GF Newlands, HR Miller, Y Kitamura
Journal: Blood (1993)
Manganese
Authors: Lloyd B. Tepper
Journal: New England Journal of Medicine (1961)

ALTHOUGH manganese in trace amounts appears to be an essential constituent (probably as a coenzyme) of plant and animal tissues, industrial atmospheric exposure to compounds of the element has been associated with disease in man. Manganese intoxication has most commonly followed exposure to excessive dust in the manufacture of manganese steels and in the mining and processing of manganese ores. Fewer cases have been described in the chemical industry and in connection with production of dry batteries.Industrial poisoning by ingestion of manganese compounds is not likely, and intoxication follows inhalation and absorption of dust. Two dissimilar clinical patterns have . . .
The educational objectives of a psychiatric residency program
Authors: J Yager, R O Pasnau
Journal: American Journal of Psychiatry (1976)

The authors present a statement of the specific educational objectives of their psychiatric residency program. This statement is designed to help residents keep in focus the central tasks of their training and to provide the faculty with an organizing matrix for curriculum development. Through such specific delineation of their objectives, residency programs can also contribute to a clarification of the specialty.
Comparing preferences for outcomes of psoriasis treatments among patients and dermatologists in the U.K.: results from a discrete-choice experiment
Authors: J.M. Gonzalez, F.R. Johnson, H. McAteer, J. Posner, F. Mughal
Journal: British Journal of Dermatology (2016)

Plaque psoriasis can have a significant negative effect on patients' quality of life, and treatments can result in serious toxicities. Although there have been several studies of patients' and physicians' relative preferences for the benefits and risks of psoriasis treatments, it is unclear how and whether patients' and physicians' preferences for the outcomes of psoriasis treatments differ. To quantify patient and dermatologist preferences for improvements in psoriasis symptoms and for increases in the risk of treatment‐related serious adverse events. Members of the U.K. Psoriasis Association and U.K. dermatologists with experience prescribing biologics completed a web‐enabled discrete‐choice experiment survey in which they evaluated efficacy and safety features of biological treatments for psoriasis. Choices between hypothetical treatment options were used to estimate preference weights indicating respondents' relative trade‐off preferences among treatment outcomes. These outcomes included improvements in the severity and coverage of psoriatic plaques and treatment‐related risks of tuberculosis, serious infections and lymphoma. Preference estimates were used to derive the maximum level of side‐effect risks that respondents would accept for improvements in psoriasis symptoms. Respondents' tolerance for side‐effect risks varied with side‐effect severity and location of plaques, and risk tolerance for serious side‐effects was greater for patients than for dermatologists. Estimates of patients' risk tolerance for serious side‐effects indicate that patients valued psoriasis symptom control highly and suggest that psoriasis symptoms have a significant effect on patients' quality of life. In light of research showing increased treatment satisfaction and improved treatment adherence among patients who receive therapies that are consistent with their preferences, our findings suggest that greater communication between dermatologists and patients about risk tolerance could help improve patient care.
Case 36-1984
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely
Journal: New England Journal of Medicine (1984)

Presentation of Case A 15-year-old boy was admitted to the hospital because of progressive neurologic deterioration. He was well until 32 months earlier, when he began to experience fatigue, pallor, and bruising. He came to this hospital, where physical examination showed anterior cervical lymphadenopalhy and hepatosplenomegaly. Microscopical examination of an aspirated specimen of bone marrow revealed almost complete replacement by blasts, without evidence of myeloid differentiation, A diagnosis of acute lymphocytic leukemia, null-cell type, was made. Induction chemotherapy was begun with vincristine, prednisone, and levo-asparaginase. The patient responded promptly, and the spleen shrank rapidly. He was discharged home on the . . .
Home Care in the 1990s
Authors: J Payne-James
Journal: JAMA (1990)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Mature, Adaptive-like CD56DIM NK Cells in Chronic Myeloid Leukemia Patients in Treatment Free Remission
Authors: Mette Ilander, Heinrich Schlums, Ulla Olsson-Strömberg, Hanna Lähteenmäki, Tiina Kasanen, Perttu Koskenvesa, Stina Söderlund, Martin Höglund, Berit Markevärn, Anders Själander, Kourosh Lotfi, Claes Malm, Anna Lubking, Marja Ekblom, Elena Holm, Mats Björeman, Sören Lehmann, Leif Stenke, Lotta Ohm, Waleed Majeed, Martin C. Muller, Hans Ehrencrona, Henrik Hjorth-Hansen, Susanne Saussele, Francois-Xavier Mahon, Kimmo Porkka, Joelle Guilhot, Yenan Bryceson, Johan Richter, Satu Mustjoki
Journal: Blood (2015)
Effects of Iophenoxic Acid on Tests of Thyroid Function
Authors: Ralph R. Hall
Journal: JAMA (1961)

TRANSMISSION from mother to child of iophenoxic acid (Teridax), a gallbladder contrast media, is now established,<sup>1,2</sup>and the fact that in one of our cases no nursing took place indicates that transmission is placental. Our experience with patients referred for clarification of thyroid studies leads us to the opinion that the problems posed by this substance are the proper basis for a brief note. This opinion is reinforced by the observation that several recent reviews of clinical tests of thyroid function make no mention of iophenoxic acid. Astwood<sup>3</sup>called attention to the special peculiarities of iophenoxic acid in 1957. It is apparently unique in its resistance to deiodination and, hence, both in its persistence in the body and in its failure to depress thyroid radioiodine uptake. The half-life of this substance appears to be 2 to 2½ years in the patients receiving the contrast media, and perhaps
Case 43-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, E.M. Ouellette, R. Fienberg
Journal: New England Journal of Medicine (1986)

Presentation of CaseAn 11-year-old girl was admitted to the hospital because of fever and a rash.The child was born of a normal second pregnancy and induced vaginal delivery, with a birth weight of 3.1 kg, and was discharged home with her mother on the fourth hospital day. Her early growth and development were normal, although she was considered a finicky eater. She had problems in comprehension at school and was required to repeat a grade one year before admission. She was well in other respects until the age of five years, when a reddish-blue, mottled rash developed on . . .
QOS-06REPAIRING THE BRAIN WITH PHYSICAL EXERCISE: AN EXERCISE TRIAL IN PEDIATRIC BRAIN TUMOR SURVIVORS. INSIGHTS FROM CORTICAL THICKNESS ANALYSIS AND DEFORMATION BASED MORPHOMETRY
Authors: Kamila Szulc, Ade Oyefiade, Lily Riggs, Eric Bouffet, Suzanne Laughlin, Brian Timmons, Jason Lerch, Cynthia de Medeiros, Jovanka Skocic, Donald Mabbott
Journal: Neuro-Oncology (2016)
Case 31-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Gerald F. Winkler, Atul K. Bhan, Edward P. Richardson
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 50-year-old postal worker was admitted to the hospital because of respiratory distress.He was in his usual state of health until four months previously, when he began to complain of fatigue and ankle edema. Three weeks before admission he experienced low-back pain that radiated down the posterior aspect of both legs to the feet, accompanied by weakness in the lower extremities. Two weeks before entry he was admitted to another hospital. Examination disclosed tenderness over the low lumbar spine, with weakness of the gastrocnemius and anterior tibial muscles, more prominent on the left side. Reflexes were . . .