tbuckley/cabot-search huggingface dataset:
Development and external validation of a nomogram and online tool to predict bowel dysfunction following restorative rectal cancer resection: the POLARS score
Authors: Nick J Battersby, George Bouliotis, Katrine J Emmertsen, Therese Juul, Rob Glynne-Jones, Graham Branagan, Peter Christensen, Søren Laurberg, Brendan J Moran
Journal: Gut (2017)

<h3>Objective</h3> Bowel dysfunction is common following a restorative rectal cancer resection, but symptom severity and the degree of quality of life impairment is highly variable. An internationally validated patient-reported outcome measure, Low Anterior Resection Syndrome (LARS) score, now enables these symptoms to be measured. The study purpose was: (1) to develop a model that predicts postoperative bowel function; (2) externally validate the model and (3) incorporate these findings into a nomogram and online tool in order to individualise patient counselling and aid preoperative consent. <h3>Design</h3> Patients more than 1 year after curative restorative anterior resection (UK, median 54 months; Denmark (DK), 56 months since surgery) were invited to complete The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 version3 (EORTC QLQ-C30 v3), LARS and Wexner incontinence scores. Demographics, tumour characteristics, preoperative/postoperative treatment and surgical procedures were recorded. Using transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) guidelines, risk factors for bowel dysfunction were independently assessed by advanced linear regression shrinkage techniques for each dataset (UK:DK). <h3>Results</h3> Patients in the development (UK, n=463) and validation (DK, n=938) datasets reported mean (SD) LARS scores of 26 (11) and 24 (11), respectively. Key predictive factors for LARS were: age (at surgery); tumour height, total versus partial mesorectal excision, stoma and preoperative radiotherapy, with satisfactory model calibration and a Mallow9s Cp of 7.5 and 5.5, respectively. <h3>Conclusions</h3> The Pre-Operative LARS score (POLARS) is the first nomogram and online tool to predict bowel dysfunction severity prior to anterior resection. Colorectal surgeons, gastroenterologist and nurse specialists may use POLARS to help patients understand their risk of bowel dysfunction and to preoperatively highlight patients who may require additional postoperative support.
Paroxysmal Nocturnal Hemoglobinuria (PNH): Long-Term Epidemiological Study.
Authors: Regis Peffault de Latour, Jean Y. Mary, Celia Salanoubat, Louis Terriou, Gabriel Etienne, Mohamad Mohty, Sophie Roth, Sophie de Guibert, Jean Y. Cahn, Gerard Socie
Journal: Blood (2006)
Monosomal Karyotype Predicts Survival In Patients with High Risk AML Undergoing Allogeneic Stem Cell Transplantation
Authors: Jan Moritz Middeke, Dietrich Beelen, Michael Stadler, Herrad Baurmann, Gesine Bug, Frauke Bellos, Brigitte Mohr, Nicole Birninger, Stefanie Buchholz, Rainer Schwerdtfeger, Hans Martin, Ute Hegenbart, Martin Bornhäuser, Gerhard Ehninger, Johannes Schetelig
Journal: Blood (2010)
Impact of Pegfilgrastim and Dosing Schedule of Cytarabine on Hematological Reconstitution Times, Incidences of Severe Infection and Duration of Hospitalization after Consolidation Therapy with High-Dose Cytarabine in Acute Myeloid Leukaemia - Interim Results from AMLSG 07-04 Trial.
Authors: Richard F. Schlenk, Konstanze Döhner, Silja Groner, Peer C. Hartmann, Jürgen Krauter, Arnold Ganser, Hartmut Döhner
Journal: Blood (2007)
Efficacy of adalimumab in patients with Crohn's disease and symptomatic small bowel stricture: a multicentre, prospective, observational cohort (CREOLE) study
Authors: Yoram Bouhnik, Franck Carbonnel, David Laharie, Carmen Stefanescu, Xavier Hébuterne, Vered Abitbol, Maria Nachury, Hedia Brixi, Arnaud Bourreille, Laurence Picon, Anne Bourrier, Matthieu Allez, Laurent Peyrin-Biroulet, Jacques Moreau, Guillaume Savoye, Mathurin Fumery, Stephane Nancey, Xavier Roblin, Romain Altwegg, Guillaume Bouguen, Gilles Bommelaer, Silvio Danese, Edouard Louis, Magaly Zappa, Jean-Yves Mary
Journal: Gut (2017)

The efficacy of anti-tumour necrosis factors (anti-TNFs) in patients with Crohn's disease (CD) and symptomatic small bowel stricture (SSBS) is controversial. The aim of this study was to estimate the efficacy of adalimumab in these patients and to identify the factors predicting success.We performed a multicentre, prospective, observational cohort study in patients with CD and SSBS. The included patients underwent magnetic resonance enterography at baseline and subsequently received adalimumab. The primary endpoint was success at week 24, defined as adalimumab continuation without prohibited treatment (corticosteroids after the eight week following inclusion, other anti-TNFs), endoscopic dilation or bowel resection. The baseline factors independently associated with success were identified using a logistic regression model, leading to a simple prognostic score. Secondary endpoints were prolonged success after week 24 (still on adalimumab, without dilation nor surgery) and time to bowel resection in the whole cohort.From January 2010 to December 2011, 105 patients were screened and 97 were included. At week 24, 62/97 (64%) patients had achieved success. The prognostic score defined a good prognosis group with 43/49 successes, an intermediate prognosis group with 17/28 successes and a poor prognosis group with 1/16 successes. After a median follow-up time of 3.8 years, 45.7%±6.6% (proportion±SE) of patients who were in success at week 24 (ie, 29% of the whole cohort) were still in prolonged success at 4 years. Among the whole cohort, 50.7%±5.3% of patients did not undergo bowel resection 4 years after inclusion.A successful response to adalimumab was observed in about two-thirds of CD patients with SSBS and was prolonged in nearly half of them till the end of follow-up. More than half of the patients were free of surgery 4 years after treatment initiation.NCT01183403; Results.
Genome alterations in sporadic gastrointestinal cancer: a comprehensive review in the literature
Authors: Takafumi Nishimura
Journal: Cancer Research (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

388 

It is widely accepted that multiple genetic alterations are required for the development of gastrointestinal cancer. However, which and how many alterations are essential for carcinogenesis has not been fully clarified. To solve this problem, a comprehensive search was conducted of the Pub-Med Database for relevant reports pertaining comparative genomic hybridization (CGH) analyses, gene amplifications, homozygous deletion s, gene mutations, gene rearrangement, and aneuploidy in sporadic esophageal, gastric, colorectal, and pancreatic cancer. Individual data from CGH analyses, that included 418 esophageal cancers, 707 gastric cancers, 396 colorectal cancers, and 142 pancreatic cancers were converted into a matrix format, and frequencies of gains and losses at each chromosomal band were calculated. Frequencies of amplifications and homozygous deletions, and gene mutations were also calculated from several series of pooled analyses. The frequent genome alterations thus detected were (+, gain; -, loss): for esophageal cancer, +3q27 (43.8%), +8q24 (45.0%), +5p15 (34.2%), +20q13 (31.8%) -3p24 (30.6%), -18q22 (28.2%), -9p21 (27.0%), amplification at 11q13 (28.8%), mutation of TP53 (42%), mitochondrial DNA (23%), and CDKN2A (13.7%); for gastric cancer, +20q13 (38.9%), +8q23 (31.7%), -19p13 (20.9%), +17q21 (20.5%), mutation of TP53 (28%), mitochondrial DNA (25%); for colorectal cancer, +20q12-q13 (49.5%), -18q22 (48.2%), +13q21 (35.6%), +8q23 (30.8%), +7p15 (30.3%), -17p13 (29.8%), amplification at 20q13 (50.2), mutation of APC (56.6%), TP53 (37.3%), KRAS (34.5%), and mitochondrial DNA (32.0%); for pancreatic cancer, -18q22 (38.0%), -9p24 (32.4%), +8q24 (31.7%), -17p12 (30.3%), +20q13 (26.1%), +3q24 (21.8%), mutation of KRAS (59.5%), TP53 (40.3%), and CDKN2A (17.5%). The total values of frequencies of each genetic alteration that showed more than 10%, that represent the expected value of the occurrence, produced an estimate of the total number of genome alterations of 8.53 for esophageal, 4.12 for gastric, 7.31 for colorectal, and 5.57 for pancreatic cancer. Striking agreement with a previous estimation based on age-distribution of these cancers (Armitage and Doll, Br J Cancer 8: 1-12, 1954) suggested that genetic changes summarized here constitute a major factor in carcinogenesis and the importance of the development of molecular targeted therapy based on recurrent chromosomal gains and losses.
Gab1 Is Involved in Erythropoietin Receptor-Mediated Survival Signal through Activation of the Erk Pathway.
Authors: Tetsuya Fukumoto, Yoshitsugu Kubota, Akira Kitanaka, Fusako Waki, Osamu Imataki, Hiroaki Ohnishi, Toshihiko Ishida, Terukazu Tanaka
Journal: Blood (2007)
Notch1 Expression Is Regulated at Post-Transcriptional Level by 3′UTR Region in Hematopoietic Stem Cell Development
Authors: Shin-ichi Mizuno, Hidetoshi Ozawa, Tadafumi Iino, Yojiro Arinobu, Chong Yong, Hirokazu Shigematsu, Koichi Akashi
Journal: Blood (2008)
Analgésie de routine versus analgésie à la demande pour les coloscopies: un essai clinique randomisé
Authors: G. Lesur
Journal: Endoscopy (2016)

L’anesthésie pour coloscopie fait parfois encore l’objet de débats en ce qui concerne ses méthodes. Le travail de cette équipe norvégienne avait pour but de comparer l’analgésie par un morphinique administré à la demande par rapport à son administration systématique.
E G Gerald Roberts
Authors: Geraint Owens
Journal: BMJ (2017)

Edwin George Gerald Roberts (“Gerry”) was born in Crosskeys, Monmouthshire. He graduated BSc from the University College of South Wales and Monmouthshire before entering medical school. After several resident junior hospital posts in hospitals across south Wales, he returned to Cardiff as registrar in paediatrics to Professor A G (“Pop”) Watkins and was subsequently appointed by the Welsh Regional Hospital Board as the consultant paediatrician at Wrexham in 1950. He was the first paediatrician to be appointed to the Wrexham General Hospital, but his duties initially covered the whole of north Wales—a responsibility he shared with a Bangor based paediatrician, Gwyn Griffith, until Muriel McClean was appointed to Rhyl in 1958.

At Wrexham, Gerry built a reputation for his holistic, multidisciplinary care of disabled children, particularly those with cerebral …
Injection-Site Cutaneous Pseudolymphoma Induced by a GM-CSF–Producing Tumor Cell Vaccine
Authors: Karl Staser, Sabra Abner, Milan Anadkat, Amy Musiek, András Schaffer
Journal: JAMA Dermatology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Dermatology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Dermatology journal
Curcumin Potentiates Antitumor Activity of Imatinib Via Inhibition of the AKT/mTOR Signaling Pathway and Down-Regulation of Bcr-Abl Gene in Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia
Authors: Yuping Gong, Yong Guo, Ting Niu
Journal: Blood (2012)
Distinctive Genomic Alterations in Testicular Diffuse Large B Cell Lymphoma
Authors: Connie Batlevi, Franck Rapaport, Lu Wang, Andrew M. Intlekofer, Amanda R. Copeland, Achim A Jungbluth, Anne Reiner, Janine D. Pichardo, Meighan Gallagher, Nancy Bouvier, Nicholas D. Socci, Frederick Criscuolo, Nikolaus Schultz, Maria Arcila, Michael Berger, Andrew D Zelenetz, Venkatraman E Seshan, Ahmet Dogan, Anas Younes
Journal: Blood (2015)
The Importance of Age, Fludarabine and Total Body Irradiation in the Incidence and Severity of Chronic Renal Failure Following Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Julio Delgado, Nichola Cooper, Kirsty Thomson, Rafael Duarte, Panagiotis Kottaridis, Karl Peggs, Stephen Mackinnon
Journal: Blood (2004)
Prevalence, risk factors, outcomes, and molecular epidemiology of mcr-1 -positive Enterobacteriaceae in patients and healthy adults from China: an epidemiological and clinical study
Authors: Yang Wang, Guo-Bao Tian, Rong Zhang, Yingbo Shen, Jonathan M Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R Walsh, Jianzhong Shen
Journal: The Lancet Infectious Diseases (2017)
Twenty‐year follow‐up using a postal survey of childhood vitiligo treated with narrowband ultraviolet B phototherapy
Authors: J.E. Lommerts, M.D. Njoo, M.A. Rie, A. Wolkerstorfer, M.W. Bekkenk
Journal: British Journal of Dermatology (2017)

Vitiligo is a depigmenting skin disorder with an estimated prevalence of 1%.(1) Childhood-onset vitiligo occurs in approximately a third of all cases.(2) Early-onset childhood vitiligo tends to be a more extensive and progressive type of vitiligo.(3) Narrowband ultraviolet-B (NB-UVB) phototherapy is an effective treatment option in active vitiligo and leads to >75% repigmentation in 14-75% of childhood cases.(4,5) Unfortunately, no evidence is available whether this repigmentation is long-lasting. To date, no data are available on the long-term efficacy and safety of NB-UVB in childhood vitiligo. This article is protected by copyright. All rights reserved
Neonatal Hemorrhagic Stroke
Authors: Catherine Amlie-Lefond, Jeffrey G. Ojemann
Journal: JAMA Pediatrics (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study
Authors: Carmel M. McEniery, Ian B. Wilkinson, Nanna B. Johansen, Daniel R. Witte, Archana Singh-Manoux, Mika Kivimaki, Adam G. Tabak, Eric J. Brunner, Martin J. Shipley
Journal: Diabetes Care (2017)

OBJECTIVE Aortic stiffness is an important predictor of future morbidity and mortality. Diabetes is associated with increased aortic stiffness, but the importance of nondiabetic glucometabolic status for accelerated aortic stiffening is unclear. We tested the hypothesis that adverse glucometabolic status is associated with accelerated aortic stiffening in individuals without diabetes, independently of known risk factors for arterial stiffening. RESEARCH DESIGN AND METHODS Glucometabolic status and other cardiovascular risk factors were assessed at baseline in 2008–09, and carotid femoral pulse wave velocity (cfPWV) at baseline and follow-up in 2012–13, in 4,386 participants without diabetes of the Whitehall II Study. RESULTS The mean age of the cohort at cfPWV baseline was 60 years, and 74% were male. cfPWV increased from (mean ± SE) 8.30 ± 0.03 to 8.98 ± 0.04 m/s during 4 years of follow-up. At baseline, cfPWV was associated with fasting and 2-h postload glucose, HbA1c, and HOMA-insulin resistance (HOMA-IR). HbA1c and HOMA-IR were associated with progression of cfPWV after adjusting for physiological confounders and cardiovascular risk factors. A 1 SD higher HbA1c and HOMA-IR were associated with greater increases in cfPWV (0.11 m/s per 5 years [95% CI 0.04, 0.18], P = 0.003 and 0.09 m/s per 5 years [0.01, 0.17], P = 0.03, respectively). Additional adjustment for BMI weakened the association with HOMA-IR but not with HbA1c. CONCLUSIONS HbA1c is independently associated with accelerated progression of aortic stiffness in individuals without diabetes. These findings suggest that long-term glucometabolic status, even in individuals without diabetes, could be an important target for preventative strategies against vascular aging.
Circulatory effect of several cerebral circulatory drugs in man, with special reference to aminophylline, papaverine, cyclandelate, vincamine, prostaglandin E1 and isoxsuprine.
Authors: Manabu Miyazaki
Journal: Circulation (1978)

Circulatory effects of several circulatory drugs, aminophylline, papaverine, cyclandelate, vincamine, prostaglandin E1 and isoxsuprine, on cerebral blood flow (blood flow in the internal carotid artery), brachial blood flow, heart rate and systolic blood pressure were investigated by means of the on-line Doppler ultrasonic technique in 33 apparently healthy males over 60 years of age, simultaneously and continuously in situ. (1) A biphasic cerebral blood flow response was induced by intravenous aminophylline, i.e., conspicuous and sustained decrease of blood flow from during to a short time after the administration, and conspicuous but transient increase of blood flow around 1 to 2 minutes after the administration. (2) A conspicuous but transient increase of cerebral blood flow was induced by intravenous papaverine. (3) A moderate or conspicuous and prolonged increase of cerebral blood flow was induced by intravenous cycladelate and vincamine. (4) Alteration of cerbral blood flow varied with intravenous prostaglandin E1 as follows. (i) No alteration of blood flow --4 subjects. (ii) Slight decrease or increase of blood flow--2 subjects each. (5) No alteration or slight increase of cerebral blood flow was induced by intramuscular isoxsuprine. (6) The findings coincide well with those obtained previously.
Alternative pathway for the development of Vα14+ NKT cells directly from CD4–CD8– thymocytes that bypasses the CD4+CD8+ stage
Authors: Nyambayar Dashtsoodol, Tomokuni Shigeura, Minako Aihara, Ritsuko Ozawa, Satoshi Kojo, Michishige Harada, Takaho A Endo, Takashi Watanabe, Osamu Ohara, Masaru Taniguchi
Journal: Nature Immunology (2017)
Kisspeptin modulates sexual and emotional brain processing in humans
Authors: Alexander N. Comninos, Matthew B. Wall, Lysia Demetriou, Amar J. Shah, Sophie A. Clarke, Shakunthala Narayanaswamy, Alexander Nesbitt, Chioma Izzi-Engbeaya, Julia K. Prague, Ali Abbara, Risheka Ratnasabapathy, Victoria Salem, Gurjinder M. Nijher, Channa N. Jayasena, Mark Tanner, Paul Bassett, Amrish Mehta, Eugenii A. Rabiner, Christoph Hönigsperger, Meire Ribeiro Silva, Ole Kristian Brandtzaeg, Elsa Lundanes, Steven Ray Wilson, Rachel C. Brown, Sarah A. Thomas, Stephen R. Bloom, Waljit S. Dhillo
Journal: Journal of Clinical Investigation (2017)

BACKGROUND. Sex, emotion, and reproduction are fundamental and tightly entwined aspects of human behavior. At a population level in humans, both the desire for sexual stimulation and the desire to bond with a partner are important precursors to reproduction. However, the relationships between these processes are incompletely understood. The limbic brain system has key roles in sexual and emotional behaviors, and is a likely candidate system for the integration of behavior with the hormonal reproductive axis. We investigated the effects of kisspeptin, a recently identified key reproductive hormone, on limbic brain activity and behavior.
Electrochemotherapy in the treatment of metastatic malignant melanoma: a prospective cohort study by InspECT
Authors: C. Kunte, V. Letulé, J. Gehl, K. Dahlstroem, P. Curatolo, R. Rotunno, T. Muir, A. Occhini, G. Bertino, B. Powell, W. Saxinger, G. Lechner, S.-H. Liew, R. Pritchard-Jones, P. Rutkowski, M. Zdzienicki, D. Mowatt, A.J. Sykes, A. Orlando, G. Mitsala, C.R. Rossi, L. Campana, M. Brizio, F. de Terlizzi, P. Quaglino, J. Odili
Journal: British Journal of Dermatology (2017)

(ECT) is an effective local treatment for cutaneous metastasis. Treatment involves the administration of chemotherapeutic drugs followed by delivery of electrical pulses to the tumour.To investigate the effectiveness of ECT in cutaneous metastases of melanoma and to identify factors that affect (beneficially or adversely) the outcome.Thirteen cancer centres in the International Network for Sharing Practices on Electrochemotherapy consecutively and prospectively uploaded data to a common database. ECT consisted of intratumoral or intravenous injection of bleomycin, followed by application of electric pulses under local or general anaesthesia.In total, 151 patients with metastatic melanoma were identified from the database, 114 of whom had follow-up data of 60 days or more. Eighty-four of these patients (74%) experienced an overall response (OR = complete response + partial response). Overall, 394 lesions were treated, of which 306 (78%) showed OR, with 229 showing complete response (58%). In multivariate analysis, factors positively associated with overall response were coverage of deep margins, absence of visceral metastases, presence of lymphoedema and treatment of nonirradiated areas. Factors significantly associated with complete response to ECT treatment were coverage of deep margins, previous irradiation of the treated area and tumour size (< 3 cm). One-year overall survival in this cohort of patients was 67% (95% confidence interval 57-77%), while melanoma-specific survival was 74% (95% confidence interval 64-84%). No serious adverse events were reported, and the treatment was in general very well tolerated.ECT is a highly effective local treatment for melanoma metastases in the skin, with no severe adverse effects noted in this study. In the presence of certain clinical factors, ECT may be considered for local tumour control as an alternative to established local treatments, or as an adjunct to systemic treatments.