tbuckley/cabot-search huggingface dataset:
Abstract 5018: Genetic and epigenetic investigation of breast carcinoma arising in Lynch syndrome families
Authors: Johanna E. Lotsari, Annette Gylling, Wael M. Abdel-Rahman, Marjukka Friman, Markku Aarnio, Heikki J. Jarvinen, Jukka-Pekka Mecklin, Teijo Kuopio, Paivi Peltomaki
Journal: Cancer Research (2012)

Abstract Breast carcinoma is the most common cancer type in females, but its incidence is generally not increased in Lynch syndrome (LS). Deficient DNA mismatch repair (MMR) is a hallmark of LS tumors that are unequivocal manifestations of the syndrome (e.g., colorectal and breast carcinoma). Because of controversial study results, it is unclear at present whether or not breast carcinoma is specifically associated with LS. We addressed this question by determining the genetic and epigenetic profiles for all available breast carcinomas from LS families from a nation-wide registry, including 24 tumors from MMR gene mutation carriers and 17 tumors from non-carriers. The average age at breast carcinoma diagnosis was similar in mutation carriers and non-carriers (56 years for each). Among breast carcinomas from mutation carriers, 43% showed loss of MMR protein corresponding to the germline mutation, and high-degree microsatellite instability (MSI-H) was present in 36%. Moreover, in mutation carriers, the age at diagnosis was lower for breast carcinomas that were MMR-deficient (by absent MMR protein and/or MSI present) compared to MMR proficient tumors (51 vs. 60 years, p= 0.031). Breast carcinomas showed frequent inactivation of tumor suppressor genes (TSG) by promoter methylation. The average number of methylated TSGs out of 24 per tumor was 3.1 for mutation carriers and 2.8 for non-carriers. The gene-specific distribution of methylation was also similar between the two breast tumor sets. In mutation carriers, the most frequently methylated TSGs were RASSF1 (77%), APC (45%), CDH13 (45%), GSTP1 (32%) and CDKN2B (27%). In non-carriers, the respective frequencies were 75%, 47%, 59%, 35%, and 29%. When compared to tumors arising in other organs from LS mutation carriers, methylation of CDKN2B was seen as a particular characteristic of breast tumorigenesis. Our investigation shows that TSG promoter methylation is a common characteristic of breast carcinomas arising in LS and affects mutation carriers and non-carriers with comparable overall rates and gene-specific distributions. Analysis of MMR protein expression and MSI revealed that while many breast carcinomas from LS mutation carriers follow MMR-driven tumorigenesis characteristic of tumors of the LS spectrum in general, a significant subset of breast tumors also exists that appears to arise and progress along separate pathways. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5018. doi:1538-7445.AM2012-5018
Endogenous Hormones and the Risk of Hip and Vertebral Fractures among Older Women
Authors: Steven R. Cummings, Warren S. Browner, Douglas Bauer, Katie Stone, Kristine Ensrud, Sophie Jamal, Bruce Ettinger
Journal: New England Journal of Medicine (1998)

In postmenopausal women, the serum concentrations of endogenous sex hormones and vitamin D might influence the risk of hip and vertebral fractures. In a study of a cohort of women 65 years of age or older, we compared the serum hormone concentrations at base line in 133 women who subsequently had hip fractures and 138 women who subsequently had vertebral fractures with those in randomly selected control women from the same cohort. Women who were taking estrogen were excluded. The results were adjusted for age and weight.
EFFECT OF PRE-TRANSPLANT MECHANICAL CIRCULATORY SUPPORT ON CELLULAR AND ANTIBODY-MEDIATED REJECTION AND SUBSEQUENT OUTCOME
Authors: Emilija M. Nestorovic, Avishay Grupper, Lyle Joyce, Natasa Milic, John Stulak, Brooks Edwards, Naveen Pereira, Richard Daly, Sudhir Kushwaha
Journal: Journal of the American College of Cardiology (2015)
Peripheral Vision in Persons with Dyslexia
Authors: Gad Geiger, Jerome Y. Lettvin
Journal: New England Journal of Medicine (1987)

We compared persons with dyslexia and normal readers with respect to how well they identified letters and short strings of letters briefly presented in the peripheral visual field at the same time that a single letter was presented at the fixation point of gaze. We found that the dyslexic subjects had a markedly wider area in which correct identification occurred in the peripheral field than did the normal readers. However, the dyslexie subjects had a "masking" between letters in the foveal field and letters in the near periphery. It appears that dyslexic persons learn to read outside the foveal field and, more generally, that there are different learned strategies for task-directed vision. Among such strategies are different mutual interactions between foveal and peripheral vision. (N Engl J Med 1987; 316: 1238–43.)
The “Class-Action” Approach to Protecting Health-Care Consumers — The Right to Psychiatric Treatment
Authors: William J. Curran
Journal: New England Journal of Medicine (1972)

THE major weapon of the welfare and consumer law advocates in the courts today is the so-called "class action." This is a broadly conceived form of law suit brought by pro bono lawyers, usually supported under O.E.O. (Office of Economic Opportunity) federal funds, but not always, on behalf of a class of consumers, welfare recipients or patients, and designed to change or to shake up "the system" as it applies to these groups. The actual number of persons named in the lawsuit may be quite small — 25 or so people who have signed their names to a petition. The . . .
Zidovudine, Didanosine, or Both as the Initial Treatment for Symptomatic HIV-Infected Children
Authors: Janet A. Englund, Carol J. Baker, Claire Raskino, Ross E. McKinney, Barbara Petrie, Mary Glenn Fowler, Deborah Pearson, Anne Gershon, George D. McSherry, Elaine J. Abrams, Jenny Schliozberg, John L. Sullivan, Rachel Behrman, James C. Connor, Seth Hetherington, Marta H. Lifschitz, Colin McLaren, Herman Mendez, Karen Millison, Jack Moye, Molly Nozyce, Karen O'Donnell, Lynette Purdue, David Schoenfeld, Gwendolynn Scott, Stephen A. Spector, Diane W. Wara
Journal: New England Journal of Medicine (1997)

Zidovudine has been the drug of choice for the initial treatment of symptomatic children infected with the human immunodeficiency virus (HIV). This trial was designed to assess the efficacy and safety of treatment with zidovudine alone as compared with either didanosine alone or combination therapy with zidovudine plus didanosine.
OP0165 Whole-body MRI for assessment of enthesitis in psoriatic arthritis, axial spondyloarthritis and healthy subjects – a comparison with 7 clinical enthesitis indices:
Authors: R.P. Poggenborg, I. Eshed, S.J. Pedersen, I.J. Sørensen, O.R. Madsen, J. Møller, M. Østergaard
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Tender entheses is a common disease manifestation in patients with psoriatic arthritis (PsA) and spondyloarthritis (SpA). Whole-body MRI (WBMRI) is a new imaging modality where patients are scanned from "head to toe" in one single scan. However, only few studies have investigated the ability of WBMRI to detect enthesitis in patients with PsA and SpA(1;2). <h3>Objectives</h3> The aim of this pilot study was to gain insight into the potential usefulness of WBMRI for detection of enthesitis in patients with PsA and SpA. <h3>Methods</h3> Patients with clinically active PsA, clinically active axial SpA and healthy subjects (HS) were included. All participants were examined for tenderness at 18 entheses (35 locations) included in the Berlin (3;4), Major (3;6), Gladman (5), Leeds (6), MASES (7), SPARCC (8) or IMPACT (9) enthesitis indices. The WBMRIs (3 tesla, T<sub>1</sub>-weighted pre- and post-contrast and STIR sequences with coronal orientation, slice thickness 4-6 mm) were anonymized and evaluated by an experienced musculoskeletal radiologist (IE). Enthesitis was scored as present, absent or not possible to evaluate. <h3>Results</h3> The PsA (n=20)/SpA (n=20)/HS (n=13) had a BASDAI of median (range) 48 (9-85)/54 (2-93)/2 (0-13) mm and DAS28: 4.35 (2.38-6.29)/3.38 (1.46-4.79)/NA. Evaluation of entheses on WBMRI was most often possible at the anterior superior iliac spine (94% of the 104 entheses), iliac crest (94%), and greater trochanter (GT) (92%), while evaluation was rarely possible at the insertion of plantar fascia into calcaneus (0%), 7th costochondral joint (2%), and patellar ligament at tibial tubercle (2%). Inflammation was frequently seen at GT (PsA/SpA: 64%/44%), Achilles tendon (36%/62%) and supraspinatus insertion on the humerus (SH) (28%/26%). There were no statistical significant associations between enthesitis on WBMRI and tender entheses assessed according to 7 enthesitis indices (see Table 1). On the level of the individual enthesis, the best agreement between clinical examination and MRI was found for the right ischial tuberosity (IT) (PsA/SpA: kappa 0.46; 0.40), left IT (SpA: 0.56), and left SH (SpA: 0.43). <h3>Conclusions</h3> WBMRI is a new promising imaging modality for evaluation of entheses in patients with PsA and SpA. Future research should include optimization of image acquisition, e.g. positioning of hands and feet, slice thickness and slice orientation. <h3>References</h3> Althoff, ARD 2007. Weckbach, EuJRad 2011. Braun, Lancet 2002. Gladman, J Rheum 2007. Gladman, J Rheum 2004. Healy, AR 2008. Heuft-Dorenbosch, ARD 2003. Maksymowych, ARD 2009. Antoni, ARD 2005 <h3>Disclosure of Interest</h3> None Declared
Abstract 1238: Gab1 regulates epithelial cell polarity and scattering by acting as a platform for PAR proteins
Authors: Ziqiang Yang, Benjamin Neel
Journal: Cancer Research (2012)

Abstract Control of cell polarity plays a key role in numerous important biological processes, but the molecules and mechanisms that regulate polarity remain poorly defined. We found that the scaffolding adaptor Gab1, a component of multiple growth factor and cytokine signaling pathways, interacts with two PAR proteins, PAR1 and PAR3. Gab1 binds PAR1 and activates its kinase activity. Acting as a scaffold, Gab1 brings PAR1 and PAR3 into a transient complex, facilitating PAR3 phosphorylation by PAR1. Gab1 and PAR6 bind the PAR3 PDZ1 domain, and thereby compete for PAR3 binding. Consequently, depletion of Gab1 causes PAR3 hypo-phosphorylation and increased PAR3/PAR6 complex formation, resulting in accelerated formation of tight junctions, increased trans-epithelial electrical resistance and a shortened lateral domain in epithelial cells. Conversely, Gab1/PAR1 interaction enhances epithelial cell scattering. Thus, Gab1 is a novel regulator of epithelial cell polarity that acts as a platform for assembling and modulating PAR protein complexes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1238. doi:1538-7445.AM2012-1238
Stimulation of Fetal Hemoglobin Synthesis by Erythropoietin in Baboons
Authors: Adil Al-Khatti, Robert W. Veith, Thalia Papayannopoulou, Edward F. Fritsch, Eugene Goldwasser, George Stamatoyannopoulos
Journal: New England Journal of Medicine (1987)

Stimulating the production of fetal hemoglobin may benefit patients with sickle cell anemia by inhibiting sickling. We gave pulsed treatments with high doses of recombinant human erythropoietin to baboons in order to test the hypothesis that the resultant rapid erythroid regeneration would stimulate F cells--i.e., cells that contain fetal hemoglobin. In normal animals, this treatment caused sharp increments in F-reticulocyte levels, which rose from 1 to 2 percent before treatment to 40 to 50 percent afterward. In two animals with chronic anemia and high levels of endogenous erythropoietin, recombinant human erythropoietin induced further increments in F-reticulocyte levels, which rose in one animal from 6 to 8 percent before treatment to 23 percent after treatment, and in the other from 20 percent before to 50 percent afterward. The time course of F-reticulocyte stimulation suggested that these cells were the products of mobilized early erythroid progenitors. These results raise the possibility that pulses of erythropoietin could be used to stimulate F-cell formation in patients with sickle cell disease.
OUTCOMES OF TRANSCATHETER CLOSURE OF POST-MYOCARDIAL INFARCTION VENTRICULAR SEPTAL DEFECT
Authors: Yu Xie, Justin CoX, Abhijeet Dhoble, Abhimanyu (Manu) Uberoi, Rahul Sharma, Tarun Chakravarty, William Collins, Raj Makkar, Fardad Esmailian, Prediman Shah, Bojan Cercek, Saibal Kar
Journal: Journal of the American College of Cardiology (2016)
Extensive Nonosseous Tc-99m HDP Accumulation in B-Cell Malignant Lymphoma
Authors: BELUR CHANDRAMOULY, ROBERT SACCHI, VASUDEV BHIDE
Journal: Clinical Nuclear Medicine (1996)

Bone scintigraphy in patients with malignant lymphoma is a useful diagnostic procedure to evaluate axial and appendicular skeleton involvement. Accumulation of bone-seeking agents by lesions in the liver, spleen, kidneys, and lymph nodes are very rare in malignant lymphomas. The authors describe a case study with extensive soft tissue Tc-99m HDP accumulation with good correlation on Ga-67 scintigraphy.
AB0726 The utility of IGA antiphospholipid antibodies for prediction of thrombotic complications in secondary antiphospholipid syndrome
Authors: T.A. Iwaniec, M. Celinska-Lowehoff, T. Goralczyk, J. Musial
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> At present we use modified classification criteria (Sydney 2006) for a diagnosis of antiphospholipid syndrome (APS) (1). These criteria do not include IgA class anticardiolipin (aCL) or antiβ2-glycoprotein I (antiβ2GPI) antibodies. However, some data indicate an association of these antibodies with APS obstetrical complications. Moreover, IgA antiβ2GPI antibodies have been associated with thromboembolic events in patients with systemic lupus erythematosus (SLE) (3). <h3>Objectives</h3> We assessed a group of APS patients with arterial (stroke, transient ischaemic attack and myocardial infarction) and venous thromboembolic events and/or obstetric complications and their association with antiphospholipid antibody profile. <h3>Methods</h3> We enrolled a group of 128 APS patients - 43 with primary (PAPS) and 85 with secondary (SAPS) - into the study. In the SAPS group 74 patients were diagnosed with SLE and 11 – with SLE-like syndrome. ACL and antiβ2-GPI antibodies in 3 classes (IgG, IgM and IgA) were determined using enzyme-linked immunosorbent assay (QUANTA Lite aCL, aβ2GPI ELISA; INOVA Diagnostics, USA). Lupus anticoagulant (LA) was assessed according to SSC 2009 guidelines (4). Statistical analyses were performed using STATISTICA software. <h3>Results</h3> We observed a positive correlation between aCL IgA and arterial thrombosis in the SAPS group only (the coefficient of correlation [Phi] =0,36, p=0,003). We also observed a weaker correlations between arterial events and LA (Phi=0,22; p=0,04) and aCL IgG (Phi=0,29; p=0,01). These associations were not found in the PAPS group. Antiβ2-GPI antibodies did not correlate with arterial thrombosis. We did not find any significant correlations between antibodies studied and venous thrombosis, or obstetrical complications. <h3>Conclusions</h3> It seems that the evaluation of IgA aCL in addition to IgG and IgM classes might add some information to the thrombotic risk assessment in patients with APS secondary to SLE. <h3>References</h3> Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4:295-306. Carmo-Pereira S, Bertolaccini ML, Escudero-Contreras A, Khamashta MA, Hughes GRV. Value of anticardiolipin and anti-beta2-glycoprotein I antibody testing in patients with pregnancy morbidity. Ann Rheum Dis 2003; 62: 640-643. Mehrani T, Petri M. Association of IgA Anti-beta2 glycoprotein I with clinical and laboratory manifestations of systemic lupus erythematosus. J Rheumatol 2011; 38: 64-68. Pengo V., Tripodi A., Reber G., Rand T., Ortel L., Galli M., DeGroot P.G. Update of the guidelines for lupus anticoagulant detection. Official communication of the SSC. J Thromb Haemost. 2009; 7: 1737-1740. <h3>Disclosure of Interest</h3> None Declared
A Controlled Study of Three Methods of Prophylaxis against Streptococcal Infection in a Population of Rheumatic Children
Authors: Harrison F. Wood, Gene H. Stollerman, Alvan R. Feinstein, Ilse Hirschfeld, Jerome H. Rusoff, Angelo Taranta, Raymond C. Haas, Jeanne A. Epstein
Journal: New England Journal of Medicine (1957)

RECURRENCES of rheumatic fever can be prevented in a high percentage of patients by carefully maintained, continuous prophylaxis against streptococcal infection.1 2 3 4 Although the effectiveness of several antibacterial agents has been repeatedly demonstrated, no large-scale attempts have been carried out by civilian organizations to obtain definitive, statistically valid epidemiologic data for prophylaxis of rheumatic children. Much of the available information has come from the study of adults in the armed forces under epidemiologic conditions that were not comparable, even for adults, to those of civilian life.5 6 7 During the period in which antistreptococcal prophylaxis has been possible, scattered individual studies of pediatric . . .
Abstract 1614: Guanylyl cyclase C signaling through vasodilator-stimulated phosphoprotein in lost in colon cancer
Authors: Josh Pelta-Heller, David S. Zuzga, Scott A. Waldman, Giovanni M. Pitari
Journal: Cancer Research (2010)

Abstract The biochemical pathway(s) induced by guanylyl cyclase C (GCC) regulates the intestinal crypt-villus axis by modulating proliferation, maturation and metabolic programming. During colorectal tumorigenesis, GCC signaling through cGMP becomes dysregulated as a consequence of the reduced expression of GCC endogenous hormones guanylin and uroguanylin. However, the significance of the loss of ligand-dependent signaling by GCC for the human disease remains unclear. Here, immunohistochemical examination of tumor specimens from patients compared to respective normal adjacent tissues revealed that the GCC signaling through vasodilator-stimulated phosphoprotein (VASP), a key regulator of actin polymerization and morphogenetic dynamics, is lost in colon cancer. Interruption of GCC signaling through VASP resulted in tumor depletion of the cGMP-dependent VASP phosphorylation species, and presumably reflected complex alterations of the normal initiation and propagation of the ligand-induced GCC signal. In vitro reconstitution of the ligand-dependent GCC signal through VASP induced a functional remodeling of human cancer cells which assumed a rounded, lamellipodia-free morphology with reduced proliferative and invasive abilities. Importantly, GCC ligand therapy in vivo restored the cGMP-dependent VASP phosphorylation circuit in intestinal tumors of APCmin/+ mice. These findings offer a previously undescribed tumor suppressor mechanism, cGMP-dependent VASP phosphorylation, with high translational potential for the diagnosis and therapy of colon cancer. Reactivation of cGMP signaling through VASP by GCC hormone replacement therapy may represent an innovative paradigm for the treatment of colorectal cancer in patients. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1614.
663 THE ROLE OF HISTOLOGY IN THE PROGNOSIS OF LIVER ADENOMATOSIS
Authors: B. Willandt, T. Roskams, C. Verslype, R. Aerts, B. Topal, W. Laleman, D. Cassiman, S. Van der Merwe, W. Van Steenbergen, F. Nevens
Journal: Journal of Hepatology (2013)
Familial Clustering of Breast and Prostate Cancers and Risk of Postmenopausal Breast Cancer
Authors: T. A. Sellers, J. D. Potter, S. S. Rich, C. R. Drinkard, R. M. Bostick, L. H. Kushi, W. Zheng, A. R. Folsom
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Familial Clustering of Breast and Prostate Cancers and Risk of Postmenopausal Breast Cancer Get access Thomas A. Sellers, Thomas A. Sellers *Division of Epidemiology, School of Public Health, and Institute of Human Genetics, University of MinnesotaMinneapolis Correspondence to : Thomas A. Sellers, Ph.D., Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S. Second St., Suite 300, Minneapolis, MN 55454–1015. Search for other works by this author on: Oxford Academic PubMed Google Scholar John D. Potter, John D. Potter Division of Epidemiology, School of Public Health, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Stephen S. Rich, Stephen S. Rich Department of Laboratory Medicine and Pathology, School of Medicine, and Institute of Human Genetics, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Carol R. Drinkard, Carol R. Drinkard Division of Epidemiology, School of Public Health, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Roberd M. Bostick, Roberd M. Bostick Division of Epidemiology, School of Public Health, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence H. Kushi, Lawrence H. Kushi Division of Epidemiology, School of Public Health, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Wei Zheng, Wei Zheng Division of Epidemiology, School of Public Health, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Aaron R. Folsom Aaron R. Folsom Division of Epidemiology, School of Public Health, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 24, 21 December 1994, Pages 1860–1865, https://doi.org/10.1093/jnci/86.24.1860 Published: 21 December 1994 Article history Received: 08 July 1994 Revision received: 09 September 1994 Accepted: 21 September 1994 Published: 21 December 1994
P1109 OVERTREATMENT OF PATIENTS WITH CHRONIC HEPATITIS C (CHC) GENOTYPE 2/3 WITH LOW BASELINE VIRAL LOAD AND RVR: EXPERIENCES IN A REAL WORLD SETTING
Authors: B. Heidrich, S.B. Wiegand, J. Petersen, H. Hinrichsen, R. Link, B. Moeller, K.H. Boeker, G. Teuber, H. Klinker, E. Zehnter, U. Naumann, H.W. Busch, U. Jacobi, M.P. Manns, H. Wedemeyer, M. Cornberg
Journal: Journal of Hepatology (2014)