tbuckley/cabot-search huggingface dataset:
Tandem Autologous Stem Cell Transplants (auto-auto) with or without Maintenance Therapy Versus Single Autologous Transplant Followed by HLA-Matched Sibling Non- Myeloablative Allogeneic Stem Cell Transplant (auto-allo) for Patients (pts) with High Risk (HR) Multiple Myeloma (MM): Results From the Blood and Marrow Transplant Clinical Trials Network (BMT-CTN) 0102 Trial
Authors: Edward A Stadtmauer, Amrita Krishnan, Marcelo C Pasquini, Marian Ewell, Edwin P Alyea, Joseph H. Antin, Hugo Castro-Malaspina, Adetola A. Kassim, Robert Negrin, Muzaffar H. Qazilbash, J. Douglas Rizzo, Scott D Rowley, Firoozeh Sahebi, George Somlo, David H. Vesole, Dan T. Vogl, Daniel J. Weisdorf, Nancy Geller, Mary M. Horowitz, David G. Maloney, Sergio Giralt
Journal: Blood (2010)
SP0113 Minimally Invasive Biopsy of Salivary Glands
Authors: C. Ungari, F. Filiaci, E. Riccardi, A. Agrillo
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Salivary gland disorders include disorder of immune system, inflammatory, bacterial, viral, and neoplastic etiologies. Diagnosis is made by radiological examinations (ultrasonography, magnetic resonance imaging, computed tomography) and biopsy of salivary glands. Minimally invasive biopsy, such as Fine-needle aspiration (FNA), are commonly used in the diagnosis of salivary gland disorders. Submucosal minor salivary gland biopsy should be done if the diagnosis of Sjögren syndrome (SS) cannot be made by history and serologic testing. Fine-needle aspiration is widely applied in the preoperative diagnosis of salivary gland lesions. Distinguishing neoplastic from non-neoplastic lesions and benign from malignant tumors of the salivary glands is extremely important for medical and surgical management of salivary gland disorders. <h3>Aims</h3> The aim of this study was to provide a systematic review of the literature to analyze the role and several aspects of minimally invasive biopsy of salivary gland disorders. <h3>Methods</h3> A systematic bibliographic search of the medical literature between January 2011 and January 2016 was conducted using electronic databases of National Library of Medicine (Medline). The bibliographic search was carried out with combination of this medical subject heading terms and text words: salivary gland, biopsy, minimal invasive biopsy, histological findings and fine-needle aspiration. For the inclusion on this review, studies had to evaluate several aspect of biopsy of salivary glands. The authors to determine the eligibility on this study performed an independent review of the finding data. <h3>Results</h3> The PubMed search identified 161 items. After a first evaluation, 57 full-text articles were finally selected for further evaluation. Of these 57 articles, 38 were excluded because they did not completely meet the inclusion criteria, whereas 19 were considered eligible for this review study. <h3>Conclusions</h3> The advantages of minimally invasive biopsy of salivary glands include decreased tissue damage, no need for anesthesia, and repeated sampling when specimens are insufficient after immediate assessment at the examination site. A biopsy of salivary glands offers valuable information for planning of subsequent therapeutic management. Fine-needle aspiration is a safe diagnostic technique that has a high specificity and sensitivity for the assessment of salivary gland disorders. The sensitivity and specificity reported is high for infective, immunological and benign lesions, whereas it decreases in cases of malignant tumors for the great variety of morphological patterns found in malignant salivary gland tumors. <h3>Disclosure of Interest</h3> None declared
Breast Cancer Resistance to Antiestrogens Is Enhanced by Increased ER Degradation and ERBB2 Expression
Authors: Tomohiro Shibata, Kosuke Watari, Hiroto Izumi, Akihiko Kawahara, Satoshi Hattori, Chihiro Fukumitsu, Yuichi Murakami, Ryuji Takahashi, Uhi Toh, Ken-ichi Ito, Shigehiro Ohdo, Maki Tanaka, Masayoshi Kage, Michihiko Kuwano, Mayumi Ono
Journal: Cancer Research (2016)

Endocrine therapies effectively improve the outcomes of patients with estrogen receptor (ER)-positive breast cancer. However, the emergence of drug-resistant tumors creates a core clinical challenge. In breast cancer cells rendered resistant to the antiestrogen fulvestrant, we defined causative mechanistic roles for the transcription factor YBX1 and the levels of ER and the ERBB2 receptor. Enforced expression of YBX1 in parental cells conferred resistance against tamoxifen and fulvestrant in vitro and in vivo Furthermore, YBX1 overexpression was associated with decreased and increased levels of ER and ERBB2 expression, respectively. In antiestrogen-resistant cells, increased YBX1 phosphorylation was associated with a 4-fold higher degradation rate of ER. Notably, YBX1 bound the ER, leading to its accelerated proteasomal degradation, and induced the transcriptional activation of ERBB2. In parallel fashion, tamoxifen treatment also augmented YBX1 binding to the ERBB2 promoter to induce increased ERBB2 expression. Together, these findings define a mechanism of drug resistance through which YBX1 contributes to antiestrogen bypass in breast cancer cells. Cancer Res; 77(2); 545-56. ©2016 AACR.
OC-032 Type 2 Diabetes and Obesity will Drive the Burden of Liver Cirrhosis in the Next Two Decades: Abstract OC-032 Table 1
Authors: R Harris, T Delahooke, TR Card, IN Guha, GP Aithal
Journal: Gut (2016)

<h3>Introduction</h3> Over the past 30 years excessive alcohol consumption has been identified as the predominant risk factor underlying the striking rise in standardised mortality rates from liver disease in the UK. However, with the increasing incidence of type 2 diabetes and obesity within the general population, the risk factor profile associated with cirrhosis may change. <h3>Aim</h3> To estimate the prevalence of clinically significant chronic liver disease amongst adults in a primary care population and identify the impact of different risk factors. <h3>Methods</h3> Asymptomatic adult patients from a primary care practice covering a population of 4600 in inner city Leicester were screened for risk factors including (1) a diagnosis of type 2 diabetes (2) a raised body mass index (BMI) of ≥27.3 kg/m<sup>2</sup> and (3) hazardous alcohol use. All of those with one or more of risk factors were invited to undergo a liver stiffness measurement using transient elastography (TE). A TE threshold of ≥8 kPa was used to make a diagnosis of clinically significant liver disease.<sup>1</sup> <h3>Results</h3> Of the 1320 patients identified with risk factors, 705 underwent TE and 82 had an increased liver stiffness measurement of ≥8 kPa (Table 1). Of those patients with hazardous alcohol use as the only risk factor, 3.5 [95% CI 0.73–9.8]% had raised liver stiffness when compared to 7.9 [95% CI 2.9–16.4]% of patients with type 2 diabetes or 8.6% [95% CI 6–11.9]% with a raised BMI. Overall 16/82 (19.5%) patients had hazardous alcohol use (with or without type 2 diabetes and a raised BMI) as a risk factor for an elevated liver stiffness measurment compared to 66/82 (80.5%) with type 2 diabetes and/or a raised BMI (without hazardous alcohol use). <h3>Conclusion</h3> In the primary care population that was screened for major risk factors of chronic liver disease, a raised BMI and type 2 diabetes accounted for over 80% of those with clinically significant chronic liver disease. Population based interventions are urgently required to address obesity and type 2 diabetes which are likely to contribute to the burden of cirrhosis in the next decade. <h3>Reference</h3> 1 Roulot D, <i>et al</i>. Transient elastography as a screening tool for liver fibrosis and cirrhosis in a community-based population aged over 45 years. <i>Gut</i> 2011;<b>60</b>(7):977–84. <h3>Disclosure of Interest</h3> None Declared
Rapid Telomere Loss in Hematopoietic Cells Associated with Development of t-MDS after Autologous Transplantation for Lymphoma.
Authors: Sujata Chakraborty, C.-L. Sun, L. Francisco, A. Komiya, H. Damasco, S.J. Forman, S. Bhatia, Ravi Bhatia
Journal: Blood (2006)
PTH-111 The Impact of Rifaximin-Alpha on NHS Hospital Resource Use in UK Patients with Hepatic Encephalopathy: A Retrospective Observational Study (Impress): Abstract PTH-111 Table 1
Authors: R Aspinall, A Radwan, G Shaya, H Sodatonou, R Cipelli, M Hudson
Journal: Gut (2016)

<h3>Introduction</h3> In clinical trials rifaximin-α (RFX) has been shown to reduce the risk of an overt episode of hepatic encephalopathy (HE) and the number of HE-related hospitalisations, but there are limited data describing its impact on healthcare resource use in real world UK practice. This study compared hospital resource use pre- and post-RFX initiation in UK patients. <h3>Methods</h3> A retrospective observational study in 11 specialist National Health Service (NHS) centres of 145 patients prescribed RFX for HE between July 2008 and May 2014. Local clinical staff reviewed patients’ medical records for demographics, RFX prescribing and adverse drug reactions (ADRs) to RFX. Details of inpatient hospitalisations and hospital visits in the 12 months pre- and post-RFX initiation were extracted from NHS Trust electronic databases. Ethics reference 14/WS/1017. <h3>Results</h3> Of the 145 patients evaluated, 89 (61%) were male. At RFX initiation, mean age was 61 years (standard deviation [SD] =11), 119 patients (82%) were on lactulose. Child-Pugh score was recorded for 67 (46%) patients (10% Class A, 54% B, 36% C). Resource use in the 6/12 months pre- and post-RFX initiation is shown in Table 1; to avoid non-survivor confounding this analysis includes the 114 patients (78%) who were alive at 6 months and 102 (70%) alive at 12 months post-RFX initiation. 3 patients (2%) had ADRs and 4 (3%) developed <i>C.difficile</i> infection (none of whom discontinued treatment). <h3>Conclusion</h3> In UK clinical practice, treatment with RFX for HE is well-tolerated and associated with significant reductions in hospitalisation frequency, bed occupancy (including critical care) and emergency room visits; reductions are observed within 6 months of treatment initiation and sustained at 12 months. This is the first study to demonstrate a reduction in critical care bed occupancy with RFX. <h3>Disclosure of Interest</h3> R. Aspinall Consultant for: Norgine. Consultant/UK advisory board member, A. Radwan Employee of: Norgine, G. Shaya Employee of: Norgine, H. Sodatonou Employee of: Norgine, R. Cipelli Consultant for: Norgine. Employee of pH Associates which was commissioned by Norgine Pharmaceuticals to provide support with study design and management, data analysis and scientific editorial services, M. Hudson Consultant for: Norgine. Attended advisory board and has given sponsored lectures (national or international) on behalf of Norgine.
Risk Factors for Graft Failure with Busulfan/Fludarabine-Based Conditioning in Children Undergoing Allogeneic Hematopoietic Cell Transplantation for Nonmalignant Disorders
Authors: Benjamin Huang, Christopher C. Dvorak, Justin Wahlstrom, Jimmy Hwang, Janel R Long-Boyle, Morton Jerome Cowan, Biljana N. Horn
Journal: Blood (2014)
High Shear Stress and Immobilization of Von Willebrand Factor Promotes the VWF-Cleaving Protease Activity as Assessed by the Cone and Plate(let) Analyzer.
Authors: David Varon, Boris Shenkman, Ulrich Budde, Dorothea Angerhaus, Reinhard Schneppenheim, Naphtali Savion, Uri Seligsohn
Journal: Blood (2004)
AB0755 The Predictive Role of High Sensitive C-Reactive Protein and High Density Lipoprotein in Development of Rotator Cuff Tear in Patients with Hand Osteoarthritis
Authors: H.-O. Kim, Y.S. Suh, Y.-H. Cheon, K.S. Park, S.-H. Kim, S.-I. Lee
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Rotator cuff tear (RCT) and hand osteroarthritis (HOA) are commonly accompanied because they share a similar pathogenesis. However, there was no previous study investigating the relationship between RCT and HOA. <h3>Objectives</h3> To estimate the prevalence and associated factors of RCT in patients with HOA. <h3>Methods</h3> In this study, we enrolled 1150 farmers who lived in Gyeongnam province in Korea from June 2013 to December 2015. Physical examinations were performed by rheumatologists and orthopedists. Plain radiography of hands and magnetic resonance imaging (MRI) of shoulders were performed in all participants. Serum levels of high sensitive C-reactive protein (hsCRP) and high density lipoprotein (HDL) were checked. RCT was diagnosed by clinical examination and MRI findings. Diagnosis of HOA was made by the 1990 American College of Rheumatology classification criteria. Severity of HOA was defined as Kellgren–Lawrence (KL) grade ≥3 on plain radiographs. Erosive HOA was defined as having eroded 9E9 or remodelled 9R9 phase of the Verbruggen. <h3>Results</h3> The prevalence of RCT was higher in patients with HOA group (192/307, 62.5%) than those without HOA (410/827, 49.5%, p&lt;0.010). Among 307 with HOA, patients with RCT were older (62.69±7.04 vs. 59.11 ±7.69, p&lt;0.001) and showed higher hs-CRP (1.51±3.78 vs. 0.67±0.70, p=0.004) and lower HDL levels (55.66±15.46 vs. 60.48±12.45, p=0.003) compared to those without RCT. There were no significant differences in gender, smoking, comorbidities, work period, body mass index, number of affected joints, HOA severity, and prevalence of erosive HOA between both groups. Multiple logistic regression analysis showed significant associations of age (odds ratio [OR] 1.06; 95% confidence interval [CI] 1.02 - 1.10), serum levels of hsCRP (OR 1.37, CI 1.04 - 1.80), and HDL (OR 2.13, CI 1.14 - 3.98) with RCT in HOA patients. <h3>Conclusions</h3> The prevalence of RCT is high and age and serum levels of hsCRP and HDL have predictive roles in the development of RCT in HOA patients. <h3>References</h3> Jin X, Beguerie JR, Zhang W, Blizzard L, Otahal P, Jones G, Ding C. Extended report: Circulating C reactive protein in osteoarthritis: a systematic review and meta-analysis. Ann Rheum Dis 2015;74(4):703–10. <h3>Acknowledgement</h3> This study was supported by a grant of the Center for Farmer9s Safety and Health, Ministry of Agriculture, Food and Rural Affairs, Republic of Korea. <h3>Disclosure of Interest</h3> None declared
Duodenal endoscopic submucosal dissection is feasible using the pocket-creation method
Authors: Yoshimasa Miura, Satoshi Shinozaki, Yoshikazu Hayashi, Hirotsugu Sakamoto, Alan Lefor, Hironori Yamamoto
Journal: Endoscopy (2016)

<b>Background and study aims</b> Duodenal endoscopic submucosal dissection (ESD) requires sophisticated endoscopic techniques because of a high rate of perforation. We introduced the pocket-creation method (PCM) of duodenal ESD to overcome difficulties. The aim of this study was to evaluate the safety and usefulness of ESD using the PCM for superficial tumors of the duodenum. <b>Patients and methods</b> We performed ESD of 17 non-ampullary duodenal lesions using the conventional method and of 28 lesions using the PCM from 2006 to 2015 and retrospectively reviewed the results, comparing the PCM and the conventional method. The median follow-up period was 35 months (range 2 – 97). <b>Results</b> There were more lesions at the duodenal angles in the PCM group compared with the conventional method group (54 % [15/28] vs. 22 % [4/17]; <i>P</i> = 0.048), and the resected specimen diameter was larger in the PCM than the conventional method group (median 37 mm [range 25 – 101] vs. 25 mm [15 – 55]; <i>P</i> = 0.007). Dissection speed was faster in the PCM than the conventional method group (9.4 mm<sup>2</sup>/min [3.0 – 15.7] vs. 6.5 mm<sup>2</sup>/min [1.5 – 19.7]; <i>P</i> = 0.09). En bloc resection was more frequent in the PCM (100 % [28/28]) than the conventional method group (88 % [15/17]) (<i>P</i> = 0.07). Perforation was significantly less frequent in the PCM (7 % [2/28]) than the conventional method group (29 % [5/17]; <i>P</i> = 0.046). The one delayed perforation in the conventional method group required surgical repair, while other intraprocedural perforations were treated by clipping. There were no recurrences. <b>Conclusions</b> ESD of duodenal lesions can be safely performed using the PCM, which stabilizes the tip of the endoscope even in difficult locations.
Cardiac Dysautonomia Predicts Long-Term Survival in Hereditary Transthyretin Amyloidosis After Liver Transplantation
Authors: Vincent Algalarrondo, Teresa Antonini, Marie Théaudin, Denis Chemla, Anouar Benmalek, Catherine Lacroix, Denis Castaing, Cécile Cauquil, Sylvie Dinanian, Ludivine Eliahou, Didier Samuel, David Adams, Dominique Le Guludec, Michel S. Slama, François Rouzet
Journal: JACC. Cardiovascular imaging (2016)
PTU-102 Critical Care Nutrition in the United Kingdom – A Survey of Current Practice
Authors: M FitzPatrick, MA Stroud, A De Silva
Journal: Gut (2016)

<h3>Introduction</h3> Patients in the intensive care unit (ICU) are at high risk of malnutrition. Consensus guidelines recommend a dietitian be part of the ICU team and available within working hours, and hospitals have a nutrition support team (NST) for patients with complex needs. We investigated the provision of nutrition support and patterns of dietetic practice on ICUs in the UK. <h3>Methods</h3> An online survey was sent to members of the Parenteral and Enteral Nutrition Group and Critical Care Group of the British Dietetic Association (n = 560). Results were analysed in Microsoft<b>®</b> Excel. <h3>Results</h3> There were 166 responses, 141 from dietitians, an estimated response rate of 30%. 134 (81%) worked in England, 18 in Scotland and 11 in Wales. Most (136, 82%) were from general ICUs, with 30 (18%) from specialist ICUs including 8 cardiac units, 8 neurosciences units, 6 transplant units, 6 HPB/liver units, 4 trauma centres, 3 burns units, 3 intestinal failure units and 1 oncology unit. Only 88 respondents (53%) said their unit had a dedicated ICU dietitian, although 149 (90%) had regular dietitian support. Only 78 respondents (47%) said their unit had dietitian input every weekday. 137 respondents (83%) said their unit had access to an NST but only 103 (62%) stated the NST attended the ICU regularly. 153 respondents (92%) said all patients on parenteral nutrition would receive dietitian input on their unit and 132 (80%) said all those on enteral nutrition would have dietitian input. Only 60 respondents (36%) said all ICU patients would have dietitian input. 107 units (64%) used actual body weight to calculate patient requirements, whilst 48 units (29%) used estimated body weight. 11 units (7%) used ideal body weight. 79% (124/156) of respondents used an equation model to calculate requirements, most commonly the Henry (53%) and Penn State equations (37%). There was significant variation in kcal/kg (range 10–35 kcal/kg, median 20–25 kcal/kg) and nitrogen intake (range 0.05–0.25 gN/kg, median 0.15–0.20 gN/kg) targets between units. 153 (94%) respondents stated their unit used gastric residual volume (GRV) to guide enteral feeding, with GRVs triggering a reduction in feed rate ranging from 200 ml to 500 ml. Specialist supplemental feeds were not commonly used, although 16 (10%) respondents said their unit used glutamine. 126 (79%) respondents said their unit followed NICE guidelines on refeeding syndrome. <h3>Conclusion</h3> Whilst dietitian and NST input is available on most ICUs, half of units lack a dedicated ICU dietitian, do not have daily dietitian involvement and lack regular NST input. There is significant variation in the methods used to calculate patient requirements, in the use of GRV and of specialist supplementation. National guidance for critical care nutrition may help reduce disparities in dietetic provision. <h3>Disclosure of Interest</h3> None Declared
Extramedullary Disease at Diagnosis of Acute Myeloid Leukemia Does Not Influence Outcome of Patients Undergoing Allogeneic Hematopoietic Cell Transplant in First Complete Remission
Authors: Fotios V. Michelis, Hans A. Messner, Naheed Alam, Vikas Gupta, Dennis Dong Hwan Kim, John Kuruvilla, Anna Lambie, Auro Viswabandya, Jeffrey H. Lipton
Journal: Blood (2015)
The PI3K Inhibitor GDC-0941 Synergizes with Standard of Care Therapies to Induce Growth Inhibition and Apoptosis of Multiple Myeloma Cells.
Authors: Veerendra Munugalavadla, Leanne Berry, Changchun Du, Sanjeev Mariathasan, Dion Slaga, Laura Sun, Marta Chesi, Peter Leif Bergsagel, Allen J. Ebens
Journal: Blood (2009)
AB0513 Pregnancy Outcome in Patients with Systemic Lupus Erythematosus
Authors: O.N. Pamuk, M.A. BAlci, N. Yilmaz, S. Yavuz
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is associated with increased pregnancy complications. In addition, pregnancy may lead to disease exacerbations in SLE. Another problem is infertility and early menopause caused by drugs, like cyclophosphamide. <h3>Objectives</h3> In this study, we aimed to evaluate pregnancy complications and menstrual problems in SLE patients. <h3>Methods</h3> Out of 400 regularly followed SLE patients, 73 patients with 86 pregnancies during the last 5-year period from 2 centers were included. SLE patients were questioned about the presence of pregnancy, history of menstrual cycle, the method of contraception, status of fertility and exacerbation of SLE during pregnancy. Their medical records were evaluated to retrieve data about the pre-mentioned questions <h3>Results</h3> During this period, 10 SLE patients had come to hospital for the treatment of infertility. 7 of them became pregnant by in vitro fertilization. 52 of SLE patients planned pregnancy before conception. Fetal loss developed in 18 patients, 6 patients experienced preeclampsia during pregnancy. Premature delivery developed in 5 patients. The frequency of fetal loss tended to be higher in SLE patients with unplanned pregnancy (38.5 vs. 25%, p&gt;0.05). Fetal loss was significantly higher in anti-phospholipid syndrome group (35% vs. 4.2%, p=0.002) and in SLE patients with hypocomplementemia (47.1% vs. 20.9%, p=0.059). SLE flares were observed in 15 patients and nephritis (8 patients) was the most common finding of exacerbation. SLE flare group during pregnancy had a significantly higher rate of hypocomplementemia (84.6% vs. 30.8%, p=0.001), premature delivery (27.3% vs. 2.3%, p=0.023), and APS (27.3% vs 7%, p=0.056). <h3>Conclusions</h3> In our cohort, fetal loss and SLE flares were relatively higher. APS and hypocomplementemia were associated with fetal loss and disease flares. <h3>Disclosure of Interest</h3> None declared
Patterns of Monoclonal Immunoglobulins and Serum Free Light Chains Are Significantly Different in African-American Compared to Caucasian MGUS Patients.
Authors: Brendan Weiss, Alex Minter, Matthew Laquer, Robin Howard, Jude Abadie, Joao Ascencao, Geraldine P. Schechter, Michael Kuehl, Ola Landgren
Journal: Blood (2009)
Long-Distance Tunneling Nanotubules Shuttle Viral Immunoglobulin Class Switch-Suppressing Factors from HIV-Infected Macrophages to B Cells.
Authors: Weifeng Xu, Paul A. Santini, Meimei Shan, Kang Chen, Susan C. Ball, April Chiu, Lawrence A. Kingsley, Charles R. Rinaldo, Amy Chadburn, Daniel M. Knowles, Bing He, Andrea Cerutti
Journal: Blood (2007)
Very High Expression of MGMT(P140K) Paradoxically Impairs Proliferation, In Vivo Selection and Protection of Transduced Hematopoietic Stem Cells.
Authors: Michael D. Milsom, Chad E. Harris, Axel Schambach, Emily Broun, Moran Jerabek-Willemsen, Christopher Baum, Thomas Moritz, Geoffrey Margison, Jürgen Thomale, David A. Williams
Journal: Blood (2007)