tbuckley/cabot-search huggingface dataset:
SAT0218 Association of Matrix Metalloproteinase-3 Level with Clinical Efficacy of Subcutaneous Methotrexate in Dmard -Naive Patients with Early Rheumatoid Arthritis
Authors: A.S. Avdeeva, E.N. Aleksandrova, D.E. Karateev, E.L. Luchikhina, A.V. Smirnov, A.A. Novikov, M.V. Cherkasova, E.L. Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To evaluate a relationship between the level of matrix metalloproteinase-3 (MMP-3) with disease activity and clinical efficacy of subcutaneous methotrexate (SC-MTX) in early DMARD -naive rheumatoid arthritis (RA) patients (pts) <h3>Methods</h3> Serum samples of 45 early RA DMARD-naive pts (35 females, median age 53.5; interquartile range 46-59.5 years, disease duration 7.0;4.0-11.5 months, DAS 28 5.8;4.9-6.4, RF positive-91%, anti-CCP positive-96%) were analyzed for the levels of MMP-3 before and after 12 and 24 weeks of treatment. In all pts SC-MTX monotherapy was started from 10 mg weekly and escalated to 20–25 mg weekly in the next 2-3 weeks. Pts were assessed every 12 weeks and if a remission was not achieved, <i>biologic therapy</i> was <i>added</i>. The duration of the study was 1 year. In the sera samples of 30 healthy donors MMP-3 levels were lower than 19.4 ng/ml (measured by ELISA) <h3>Results</h3> After 12 months 16 pts (35.6%), DAS 28 1.7;1.6-4.1, had received SC-MTX monotherapy. In 29 active RA pts (64.4%), DAS 28 3.1;1.9-4.3 <i>biologic therapy</i> was added (82% adalimumab, 13% abatacept, and 5% other agents). MMP-3 levels in RA pts were higher than in healthy donors: 46.7;15.5-64.5 – and 7.74; 5.5-11.8, respectively, p&lt;0.05. Elevated MMP-3 levels were observed in 64.4% of pts. These pts had both higher disease activity and erosion score as compared to pts with normal MMP-3 levels (Table1) At week 12 and 24, MMP-3 decreased in SC-MTX monotherapy group: 23.7 (1.5-44.5) and 0.025 (0.025-29.0), p&lt;0.05 for both cases; in SC-MTX and <i>biologic therapy</i> group: 31.7 (16.3-72.0) and 7.0 (0.03-29.0), respectively, p&lt;0.05 for both cases, as compared to baseline. At baseline, low disease activity (DAS 28 4.4;4.4-5.7, SDAI 24.1;16.9-35.7, CDAI 20.7;15.8-30.0) and low MMP-3 levels (10.6;0.03-38.1) were observed in SC-MTX monotherapy group (n=16) compared with SC-MTX plus <i>biologic therapy</i> group (n=29) (6.05;5.3-6.7, 40.7;26.7-48.2 35.8;23.5-42.8 and 58.8;27.0-106.3, respectively), p&lt;0.05 for all cases. After ROC analysis we found that elevated MMP-3 levels at baseline (&gt;54.6) and week 12 (&gt;25.1) were associated with the lack of SC-MTX efficacy at 48 weeks of the observation (AUC 0,78 95% CI 0,63-0,93 and AUC 0,96 95% CI 0,54-0,86, respectively) Fig.1, 2. <h3>Conclusions</h3> High MMP-3 level at baseline and after 12 weeks of SC-MTX monotherapy could be considered as a possible predictor of a poor response of SC-MTX treatment <h3>Disclosure of Interest</h3> None declared
Problem of diagnosis in postmortem brain studies of schizophrenia
Authors: C Hill, N Keks, S Roberts, K Opeskin, B Dean, A MacKinnon, D Copolov
Journal: American Journal of Psychiatry (1996)

The purpose of this study was to determine 1) the reliability of diagnoses of schizophrenia at coronal autopsy and 2) the degree to which the use of different diagnostic instruments for schizophrenia would affect postmortem brain research.Eighty-three subjects, recorded at coronal autopsy as having had schizophrenia, were referred for neurochemistry studies. The diagnoses reported to the state coroner's office were reevaluated by a review of psychiatric case histories by clinicians using semistructured assessment and diagnostic criteria.The application of DSM-III-R, Research Diagnostic Criteria (RDC), ICD-10, Schneiderian, and Feighner criteria to the diagnosis of the 83 subjects revealed that 63.9%, 48.2%, 48,2%, 43.4%, and 42.2%, respectively, met the criteria for schizophrenia. Highest concordance was between the RDC and ICD-10 systems, while lowest concordance was between the RDC and Schneider systems.These data suggest that unless carefully reviewed, diagnosis may be a major confounding factor in postmortem studies of brain tissue from subjects with schizophrenia.
Patterns of illicit drug use in the Army
Authors: R F Cook, R S Hostetter, D A Ramsay
Journal: American Journal of Psychiatry (1975)

The authors collected detailed histories of illicit drug use in the Army in individual interviews with a stratified random sample of 262 enlisted men at six military posts across the United States. Approximately half of the sample (N equals 128) were classified as drug users; 90 of these individuals were identified as career multiple-drug users. Most of these subjects used a variety of drugs in frequently changing patterns. The authors emphasize the individualistic nature of drug use and question the appropriateness of an addiction model for most users of illicit drugs.
Electron Microscopy of Mouse Parotid Tumor (Polyoma) Virus
Authors: H. Kahler, W. P. Rowe, B. J. Lloyd, J. W. Hartley
Journal: JNCI Journal of the National Cancer Institute (1959)

Crude tissue-culture fluids containing a virus which had been shown by previous workers to induce multiple tumors in mice and hamsters yielded a characteristic particle when examined with the electron microscope. Absorption and elution from red blood cells and density gradient centrifugation were utilized for further purification. The size of the particle in arrays was 40 to 45 mμ; in flattened, oblate spheroids it was 59 mμ in the major diameter and 24.2 mμ in height, which gave 44 mμ as the diameter of the sphere having the same volume as the flattened particle. Virus from 2 tissue-culture strains, one cultured from a parotid-gland tumor and the other from a mesenteric lymph-node tumor, appeared identical. Sedimentation experiments indicated that the particles were somewhat larger in solution. Particle counts from the electron micrographs were parallel to the hemagglutination (HA) titer. In one experiment the number of virus particles was 1 × 107 times the HA titer. The end point of hemagglutination corresponded to the virus dilution in which the ratio of virus particles to red blood cells was unity. The uniformity of virus size is consistent with the concept of a single virus, but morphology alone is an insufficient basis for such a conclusion.
The treatment of anorexia nervosa
Authors: L K Hsu
Journal: American Journal of Psychiatry (1986)

The author reviews recent advances in the treatment of anorexia nervosa. In addition to the usual areas of weight restoration and psychotherapy, he focuses on difficult issues such as how to engage the patient in treatment, the evaluation of the patient, treatment goals, outpatient treatment, and treatment of bulimic and chronic patients. Where expert opinions differ, the author attempts to give a balanced view while acknowledging the relative lack of research data.
SP0089 Studying the Role of Extracellular Vesicles on Human in Vitro Osteoclastogenesis
Authors: N. Marton
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Extracellular vesicles (EVs) are submicron-sized carriers of a variety of biomacromolecules, cytokines, autoantigens, enzymes, pathogen- and damage-associated molecular patterns besides DNA and RNA. Exosomes are the smallest EVs, their size range is about 50-100 nm whereas the diameter of microvesicles (MVs) is between 100 and 1000 nm. EVs are likely participants during intercellular comunication. Thus far, their role on human osteoclast differentiation and activation is unknown. <h3>Objective</h3> To investigate the effect of EVs on human osteoclast differentation and gene expression. <h3>Methods</h3> Monocytes were isolated from PBMCs using positive selection <i>(EasySep, StemCell)</i> and treated with 50 ng/ml recombinant human macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RANKL). Samples were treated with either blood- or U.937 monocyte cell line-derived MVs, exosomes; or with soluble immune complexes (sIC, generated from purified human immunoglobulin G and Staphylococcal Protein A); or were left untreated. On day 8, total RNA was isolated or the samples were fixed and stained for tartrate resistant acid phosphatase (TRAP) expression. TRAP positive cells with a minimum of 3 nuclei were counted. The expression of calcitonin receptor (CALCR), c-Fos, cathepsin K, M-CSF receptor (c-Fms), transmembrane 7 superfamily member 4 (DC STAMP), nuclear factor of activated T-cells cytoplasmic 1 (NFATc1), osteoclast associated immunglobuline-like receptor (OSCAR), RANK, TRAP and Src like adaptor protein 2 (SLAP-2) <i>(IDT</i>) were analyzed by quantitative real-time polymerase chain reaction. <h3>Results</h3> Immune complexes (n=8) profoundly inhibited the osteoclast differentiation. Blood- and cell line-derived MVs (n=7) did not alter the number of mature osteoclasts. By contrast, exosomes isolated from plasma and U937-derived supernatant (n=7) significantly (p&lt;0.05) decreased the number of the TRAP positive multinucleated cells. Both U.937-exosome and sIC treatment (n=4) increased the c-Fos, c-Fms, OSCAR expression and decreased the CALCR expression. <h3>Conclusions</h3> Our present data suggest that exosomes, or their cargo, may have a role in the regulation of osteoclastogenesis. This provides a novel insight into the regulation of osteoclast development in the context of inflammatory arthritis in which exosomes have been detected. <h3>Disclosure of Interest</h3> None declared
Something Old, Something New, Something Borrowed, Something Fused: Novel <i>EGFR</i> Rearrangements in Lung Adenocarcinomas
Authors: Paul K. Paik
Journal: Cancer Discovery (2016)

Abstract Summary: Mutations in EGFR stand as the archetype for somatic alterations that lead to oncogene addiction and that predict for response to targeted therapies. In this issue of Cancer Discovery, Konduri and colleagues report on a pair of novel oncogenic and actionable EGFR fusion events in a series of patients with lung adenocarcinomas, casting new light on this model gene. Cancer Discov; 6(6); 574–5. ©2016 AACR. See related article by Konduri et al., p. 601.
The Use Of Selected Parameters Of Bone Microenvironment For The Assessment Of Skeletal Involvement and Activity In Multiple Myeloma and Monoclonal Gammopathy Of Undetermined Significance
Authors: Jiri Minarik, Petra Pusciznova, Pavla Petrova, Miroslav Herman, Tomas Pika, Jan Hrbek, Jaroslav Bacovsky, Jana Zapletalova, Vlastimil Scudla
Journal: Blood (2013)
Localized Airspace Consolidation of Pulmonary Alveolar Proteinosis Mimicking Malignant Lesions in 18F-FDG PET/CT Imaging
Authors: Yan-li Wang, Na Fang, Lei Zeng, Zeng-jie Wu, Xin-jian Cui
Journal: Clinical Nuclear Medicine (2015)

Pulmonary alveolar proteinosis is a rare lung disease caused by diffuse, abnormal intra-alveolar surfactant accumulation. Here, we report a case of autoimmune pulmonary alveolar proteinosis with heterogeneous accumulation of F-FDG in both lungs shown on the combined F-FDG PET/CT.
Activated idiotype-reactive cells in suppressor/cytotoxic subpopulations of monoclonal gammopathies: correlation with diagnosis and disease status
Authors: U Dianzani, A Pileri, M Boccadoro, A Palumbo, P Pioppo, A Bianchi, A Camponi, G Fossati, S Battaglio, M Massaia
Journal: Blood (1988)
The Occurrence of Skin Tumors in Untreated Albino Mice from Dealer's Stock&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Philippe Shubik, Kay Spencer, Giuseppe Della Porta
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article The Occurrence of Skin Tumors in Untreated Albino Mice from Dealer's Stock Get access Philippe Shubik, Philippe Shubik Division of Oncology, The Chicago Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Kay Spencer, Kay Spencer Division of Oncology, The Chicago Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar Giuseppe Della Porta Giuseppe Della Porta Division of Oncology, The Chicago Medical School, Chicago, Illinois Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 1, July 1957, Pages 33–36, https://doi.org/10.1093/jnci/19.1.33 Published: 01 July 1957 Article history Received: 08 March 1957 Published: 01 July 1957
PTH-219 Prevalence of intestinal failure-associated liver disease within a home parenteral nutrition service
Authors: M Fitzpatrick, A Evans, A De Silva
Journal: Gut (2015)

<h3>Introduction</h3> Intestinal failure-associated liver disease (IFALD) is a potentially life-threatening and historically common complication of long-term parenteral nutrition. In the past two decades advances in catheter sepsis prevention and the development of novel lipid formulations have reduced the prevalence of IFALD. We examined the point prevalence of surrogate markers of IFALD within the home parenteral nutrition (HPN) service at the Royal Berkshire Hospital. <h3>Method</h3> The records of the HPN service were examined to identify patients receiving HPN between January 2012 and December 2014. Clinic notes, electronic patient records and imaging results were used to extract clinical information. <h3>Results</h3> Twenty-four patients (13 male; mean age 60 years, range 21–83 years) received long-term home parenteral nutrition during the study period for a mean duration of 25 months (range 3–54 months). Underlying causes of intestinal failure included inflammatory bowel disease (7, 29%), vascular causes (5, 21%), surgical complications including fistulae, sepsis and adhesions (5, 21%), malignancy (4, 17%) and dysmotility (3, 12%). Most patients received a tailor-made PN bag 3–7 days a week (median 5 days a week) with a lipid emulsion (SMOF) bag twice a week. In this cohort 16 patients had persistently abnormal liver biochemistry (raised ALT and/or ALP greater than the reference range for longer than six months). Two patients had mildly elevated bilirubin (1–2 x upper limit of normal). There were no clinical presentations of decompensated liver disease. Nineteen patients had hepatic imaging (ultrasound or CT) during the study period. One patient had splenomegaly secondary to portal vein thrombosis and one patient had ascites related to Budd-Chiari syndrome. No other patients had radiological signs of portal hypertension or cirrhosis on imaging. Three patients underwent transient elastography measurement (Fibroscan<sup>®</sup>) one of which had an elevated reading (10.7kPa, IQR 1.5). <h3>Conclusion</h3> These results show that two thirds of patients on long-term parenteral nutrition had persistent abnormalities in liver biochemistry which may indicate steatohepatitis. No patients showed signs of cirrhosis on imaging or presented with decompensated liver disease during the three-year study period. Whilst this is a relatively short follow-up period to detect the development of chronic liver disease, previous studies have reported a prevalence of complicated liver disease of 26% after two years of PN.<sup>1</sup>We plan to prospectively monitor liver biochemistry, abdominal imaging and transient elastography in our HPN cohort to assess the natural history of IFALD. <h3>Disclosure of interest</h3> None Declared. <h3>Reference</h3> Cavicchi M <i>et al</i>. Prevalence of liver disease and contributing factors in patients receiving home parenteral nutrition for permanent intestinal failure. Ann Intern Med. 2000;132:525–532
Pneumocystis carinii pneumonia with peripheral nodular infiltrates in a patient with T-acute lymphoblastic leukemia.
Authors: G G Wulf, U Reichard, B Wormann, W Hiddemann
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.10.3476 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9779726 Pneumocystis carinii pneumonia with peripheral nodular infiltrates in a patient with T-acute lymphoblastic leukemia. G G WulfxG G WulfSearch for articles by this author , U ReichardxU ReichardSearch for articles by this author , B WormannxB WormannSearch for articles by this author , W HiddemannxW HiddemannSearch for articles by this author Show More Georg-August-Universitat, Gottingen, Germany. https://doi.org/10.1200/JCO.1998.16.10.3476 PDF "Pneumocystis carinii pneumonia with peripheral nodular infiltrates in a patient with T-acute lymphoblastic leukemia.." Journal of Clinical Oncology, 16(10), pp. 3476–3477© 1998 by American Society of Clinical Oncology
Some Encouragements in Cancer Surgery.
Authors: F W RANKIN
Journal: JAMA (1926)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PROTECTIVE INOCULATION AGAINST CHOLERA.
Journal: JAMA (1892)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stromal Cell CD9 Regulates Differentiation of Hematopoietic Stem/Progenitor Cells
Authors: Keisuke Aoyama, Kenji Oritani, Takafumi Yokota, Jun Ishikawa, Tetsuo Nishiura, Kensuke Miyake, Yuzuru Kanakura, Yoshiaki Tomiyama, Paul W. Kincade, Yuji Matsuzawa
Journal: Blood (1999)
PTU-215 Preferences for alternative haemorrhoid treatments: does type of treatment matter?
Authors: MM Kilonzo, N Krucien, M Ryan, A Watson
Journal: Gut (2015)

<h3>Introduction</h3> The treatment of haemorrhoids aims to relieve symptoms and improve quality of life. However, generic tools used to measure quality of life in economic evaluation may not be sensitive to patients’ preferences for alternative treatment modalities and their associated outcomes. Discrete choice experiments (DCEs) are increasingly used in health economics as an alternative method to value health care. This technique can be used to investigate the tradeoffs that people are willing to make between different attributes of treatments. <h3>Method</h3> Based on literature reviews and expert opinion, four important attributes of haemorrhoid treatment were identified: time in post operative pain; chance of serious complications requiring hospitalisation; time taken to return to usual activities; and chance of a recurrence of haemorrhoidal symptoms. Experimental design techniques were used to create a manageable number of choices between the alternative treatment modalities, which varied with respect to the levels ascribed to the treatment attributes and also a cost attribute, that was included to enable estimation of individuals’ willingness to pay (WTP) for the different treatment modalities and attributes. The study was conducted using a sample of the general population from an online survey panel. Response data were analysed using conditional logistic regression techniques. <h3>Results</h3> Of the 1010 respondents who completed the DCE, 44% had experienced haemorrhoids. Very few respondents chose not to be treated and none of the surgical treatment modalities were preferred over the others. The coefficients for all the attributes had the expected sign and were significantly different from zero (p &lt; 0.0001). For example, an increase in chance of recurrence or the amount of time spent in pain was associated with a decrease in the probability of selecting an option. A marginal change in the chance of recurrence of haemorrhoidal symptoms had the greatest influence on respondents’ choices, WTP for a percentage reduction in the chance of recurrence of haemorrhoidal symptoms and a percentage reduction in chance of serious complications was £189 and £117 respectively. Individuals were willing to pay £14 to reduce the time spent in post-operative pain by one day, and £14 to reduce the time taken to return to usual activities by one day. <h3>Conclusion</h3> After accounting for the main associated attributes and outcomes of treatment, the type of treatment <i>per se</i>does not significantly influence patients’ choices. The findings suggest that the outcomes of haemorrhoidal surgery influence the respondent choices and there is need for further research to put these findings into context by combining these results with evidence from randomised controlled trials to establish the most cost beneficial approach to treatment. <h3>Disclosure of interest</h3> None Declared.
Bioabsorbable radiopaque water-responsive shape memory embolization plug for temporary vascular occlusion
Authors: Yee Shan Wong, Abhijit Vijay Salvekar, Kun Da Zhuang, Hui Liu, William R. Birch, Kiang Hiong Tay, Wei Min Huang, Subbu S. Venkatraman
Journal: Biomaterials (2016)
The prevalence and ramifications of psychopathology in psychiatric residents: an overview
Authors: H D Campbell
Journal: American Journal of Psychiatry (1982)

Although estimates of psychopathology in psychiatric residents vary from 4% to 22%, at either end of the spectrum emotional disturbance is a significant problem that merits greater attention. The prevalence of psychopathology may be seriously underestimated when obtained from residency program directors, who may be aware of only the most blatant cases. On the other hand, figures that rely on self-report of the subjective impressions of faculty may be spuriously inflated by transient manifestations of stress commonly experienced during residency training in psychiatry. The author makes recommendations for improved screening of candidates and greater commitment by training programs to recognizing and meeting the emotional needs of psychiatric residents.