tbuckley/cabot-search huggingface dataset:
SAT0324 A population based study of the association between hip bone marrow lesions and pain
Authors: H. Ahedi, D. Dore, L. Blizzard, F. Cicuttini, G. Jones
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Bone marrow lesions (BMLs) are detected using magnetic resonance imaging (MRI) and defined as non-cystic ill-defined subchondral areas of high signal intensity. BMLs are now considered as one of the key pathologic features in knee osteoarthritis (OA)<sup>1,2</sup>. However there has been no research-examining hip BMLs and their relation to pain and cartilage. <h3>Objectives</h3> The aim of this study was to investigate the cross-sectional relationship between hip BMLs, cartilage signal change and pain. <h3>Methods</h3> Four hundred and forty three randomly selected older adults (mean age 63 yrs) were included in this study. They had a right hip MRI using standardized protocols (both T1 and T2-weighted). Acetabular and femoral hip BML presence was defined as being adjacent to the cartilage bone interface. Bml size (cm<sup>2</sup>) was assessed manually by drawing contours around the outer edges of the lesion on the sagittal T2-weighted MR images. High cartilage signal intensity was recorded (yes or no). Hip pain and knee pain were assessed using the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index pain score. <h3>Results</h3> Sixty-nine participants (15.6%) had either a femoral or acetabular BML. Acetabular BML presence was not associated with hip or knee pain. Knee pain (but not hip pain) was more common in people with a femoral BML (83% v 16%,p=0.03). On average, acetabular BML size (0.66 cm<sup>2</sup>) was larger than femoral BML size (0.11cm<sup>2</sup>). Acetabular BML size was significantly associated with hip pain (p=0.02) while femoral BML size was significantly associated with knee pain (p&lt;0.001) but not vice versa. This was especially notable in males (Figure 1). Hip BMLs were strongly associated with increased cartilage signal in the hip (58% v 2%,p&lt;0.001) but increased cartilage signal was not associated with hip or knee pain. <h3>Conclusions</h3> Hip BMLs are common and have site-specific associations with pain. Further, hip BMLs are associated with high cartilage signal change, which is asymptomatic but implies BMLs have a deleterious effect on overall joint health. Thus, hip BMLs may also be a key player in hip osteoarthritis. <h3>References</h3> Zhai G et al. Arthritis care and Research 55(2): 264-271; 2006 Dawn Dore et al. Arthritis Research and Therapy 12(6): R222, 2010 <h3>Disclosure of Interest</h3> None Declared
Young commuters are most keen to choose an out of area GP
Authors: J. Wise
Journal: BMJ (2014)

A government pilot scheme that allows patients to choose a GP outside the area where they live has had low demand but is most popular with younger commuters and those who have recently moved house.

From October 2014 patients in England will be able to register with volunteer general practices outside the area where they live. The Department of Health’s Choice of GP pilot scheme ran for a year with volunteer practices in four primary care trusts in Westminster, Salford, Manchester, and Nottingham.

In the scheme, patients could either register with a pilot practice as an out of area patient or be seen as a day patient while remaining registered with their …
A8.11 Efficacy and safety of abatacept in patients with early and long-standing rheumatoid arthritis
Authors: MA Kanonirova, GV Lukina, YA Sigidin, ES Aronova, EL Luchihina, DE Karateev, EL Nasonov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background and objectives</h3> Abatacept (ABA) is a selective co-stimulation modulator. ABA is widely used in treatment of RA. There isn't enough data about the effectiveness of ABA at different stages of RA. <h3>Objectives</h3> To compare effect of ABA in patients (pts) with early (ERA) and long-standing (LS) RA. <h3>Materials and methods</h3> Eighty patients with early (less than three years duration, 51%) and LS (more than three years duration, 49%) RA and an inadequate response to synthetic DMARDs or biologics (adalimumab, rituximab, tocilizumab) were enrolled in the study. Most of them were women, age 49 ± 13 years, with a high disease activity (DAS28=5,28 ± 1,1), RF-positive (75.7%) and ACPA-positive (75%). Disease activity was assessed by DAS28. Results were assessed every 12 weeks according to EULAR criteria. <h3>Results</h3> Before treatment in patients with early RA DAS28 was 5.26 ± 0.89, with long-standing RA - 5,3 ± 1,3. After 3 months of therapy good and moderate response by EULAR criteria was achieved in 82.2% in the group of ERA and in 67.5% of patients with LS RA (p &lt; 0.05). There was no significant difference in achieving good EULAR response between two groups after 3 months (26.47% - ERA; 25.7% - LS RA) and 6 months of therapy (31.9% - ERA; 35.2% - LS RA). The number of non-responders in pts with LS RA was significantly higher both after 3 months and 6 months (32.35% and 25.3%) as compared to pts with ERA (17.6% and 17.02% respectively). 25 adverse events (AE) in 19 (23%) pts were registered. The most frequent AE were upper respiratory tract infections - 8 pts. One pt has herpes zoster and one, abscess of the right thumb. <h3>Conclusion</h3> Abatacept has shown significant improvement in reduction of disease activity in pts with an inadequate response to previous therapy. There was no significant difference in achieving good EULAR response between pts with early and LS RA. There were more patients with an inadequate response to ABA in the LS RA group. ABA was well tolerated, AE were registered only in 23% of patients. ABA is an effective drug with a good safety profile. ABA has found its niche in the treatment of both LS and ERA.
PWE-040 Lymph node metastasis in early oesophageal cancer: experience from a 10 year UK cohort
Authors: T S Athwal, S Love, S Bruce, R Page, M Hartley, N Howes
Journal: Gut (2012)

<h3>Introduction</h3> Surgical resection is considered the gold standard curative treatment for oesophageal cancer, however, there is debate regarding the role of endoscopic resection for “early” (Tis, T1) oesophageal cancer. However, studies have identified that a significant number of early cancers will have lymph node metastases (LNM) at time of diagnosis. The aim of this study was to determine the incidence of LNM in early oesophageal cancer patients in a 10 year UK cohort. <h3>Methods</h3> A total of 482 consecutive patients who had transthoracic oesophagectomy for adenocarcinoma or squamous cell carcinoma, at a supra-regional upper GI cancer centre, were registered on a prospective database between 2002 and 2012. Patients with early oesophageal cancer were retrieved from the database based on pre-operative endoscopic and radiological staging. <h3>Results</h3> Of the 482 patients, 53 (11%) had early oesophageal cancer, of which 41 (77%) were adenocarcinoma, 11 (21%) squamous cell carcinoma and 1 (2%) carcinoma in situ. The median lymph node harvest was 14 (IQR 9–17). Lymph node metastases were present in 4 (7.6%) cases, all of which had tumour extending into the submucosal layer. <h3>Conclusion</h3> Early oesophageal cancer has a significant risk of lymph node involvement especially when the submucosal layer is breached by tumour. In our opinion, surgical resection remains the gold standard to achieve cure in patients with early cancer. <h3>Competing interests</h3> None declared.
Abstract 1289: The recombinant kringle domain of urokinase plasminogen activator (uPA) inhibits VEGF165-induced proliferation of HUVEC cells
Authors: Byeong Mo Kim, Young Ae Joe, Sung Hee Hong
Journal: Cancer Research (2010)

Abstract Angiogenesis is associated with tumor growth, invasion and metastasis. Many growth factors and cytokines are engaged in angiogenesis. Among them, vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors and stimulates endothelial cell proliferation, protease expression, migration and subsequent differentiation to form new vessels. It has been previously revealed that the recombinant kringle domain of urokinase plasminogen activators (uPA) (UK1) exerts antiangiogenic activity against VEGF-induced angiogenesis using in vitro or in vivo model. In this study, we explored molecular signaling mechanisms involved in this activity. The antiangiogenic mechanism of UK1 was investigated in vitro by measuring phosphorylation levels of VEGF signaling proteins. VEGF165 stimulates the phosphorylation of VEGF/VEGFR2 signal molecules, and pre-treatment with UK1 blocked not only VEGF-induced phosphorylation of VEGFR2 but also phosphorylations of downstream signaling proteins, such as Erk and Akt. In addition, VEGF induced secretion of MMP2 in HUVEC, which efficiently suppressed by UK1 pre-treatment. However, mRNA levels of MMP2 as well as of MMP9, Timp1 and Timp2 remained unaffected by UK1. Overall, our findings suggest that UK1 inhibits VEGF-induced proliferation and migration of HUVEC by suppressing VEGF/VEGFR2-mediated angiogenic signals and MMP2 activity. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1289.
Case 23-2004
Authors: William E. Hurford, Alexander Kratz
Journal: New England Journal of Medicine (2004)

A 50-year-old woman was found to have low oxygen saturation by pulse oximetry on preadmission testing for a hysterectomy. She had had an episode of cyanosis after general anesthesia in the past. A physical examination, radiographic studies, pulmonary-function testing, and echocardiography revealed no abnormalities. A diagnostic procedure was performed.
AB1419-HPR Learning curve of a rheumatology nurse in the acquisition of ultrasound images of metacarpophalangeal joints in patients with chronic arthritis
Authors: A. Moretti, G. Gubinelli, M. Gutierrez, W. Grassi
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Nurses play a key role of interface between patients and the rheumatologist. There is an increasing evidence that specialist nurses can be involved in a wide range of advanced activities in patient management including clinimetry, patient education, counseling, capillaroscopy and intra-articular injections (1). Targeted ultrasound (US) could be another activity to consider in order to promote the extended role of rheumatology nursing (2). <h3>Objectives</h3> To evaluate the learning curve of a nurse without experience in musculoskeletal US who attended an intensive training programme focused on the acquisition technique of US images at metacarpophalangeal (MCP) joints in patients with chronic arthritis. <h3>Methods</h3> Two investigators (1 rheumatologist expert in US and faculty member of theEULAR US courses and 1 nurse without previous experience in US) participated in the exercise. US images were obtained from 6 selected patients with different chronic arthritis (3 rheumatoid arthritis, 3 psoriatic arthritis). The training program has been structured in two phases. The first phase (first day) has been focused on basic technical characteristics of the US equipment and the appropriate settings [greyscale and power Doppler (PD)] to obtain high quality US images. The second phase consisted of three sessions of intensive scanning activity (3 hours per day for three consecutive days). The US images acquired by the nurse have been successively evaluated by the rheumatologist. For each US image the following four parameters were considered using a qualitative score (not correct=0 or correct=1): 1= setting of the equipment; 2= visualization of bone profile and cartilage; 3= visualization of tendon; 4= position of the transducer. The possible score for each image ranged from 0 to 4. <h3>Results</h3> A total of 48 images of MCP joints in 6 patients were assessed. The global scores attributed at the nurse US images showed a significant progressive improvement from the beginning to the end of the exercise [median (95% CI for the median): 2 (1.00 – 2.04) to 3 (3.00 – 4.00) p=0.0002]. <h3>Conclusions</h3> Our results suggest that a nurse without experience in US is able to acquire high quality US images of MCP joints in patients with chronic arthritis after a short intensive 12 hours training programme. <h3>References</h3> Carr A. Defining the extended clinical role for allied health professionals in rheumatology. ARC Conference Proceedings NO12, Arthritis Research Campaign, 2001, Chesterfi eld, UK. Filippucci E, Unlu Z, Farina A, Grassi W. Sonographic training in rheumatology: a self teaching approach. Ann Rheum Dis 2003;62:565-67. <h3>Disclosure of Interest</h3> None Declared
U of Alabama Smokeless Tobacco Study Under Fire
Authors: C. Nelson
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article U of Alabama Smokeless Tobacco Study Under Fire Get access Corinna Nelson Corinna Nelson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 16, 17 August 1994, Page 1193, https://doi.org/10.1093/jnci/86.16.1193 Published: 17 August 1994
An Approach to the Skid Row Problem in Boston
Authors: David J. Myerson
Journal: New England Journal of Medicine (1953)

IN every city there are many men whose dominating drive and desire to drink have led them to an existence so submarginal that they represent a serious social, economic and health problem to all community-minded citizens. This paper discusses the characteristics of such alcoholic patients observed in the Long Island Hospital, Boston, Massachusetts, and describes the rehabilitation program now operating at this hospital.These are homeless men. Whether high-born or low-born, intelligent or stupid, religious or agnostic, they have lost or abandoned all previous personal contacts, and drift alone through the rooming-house sections of Boston, such as the South End, . . .
Long-Term Treatment with Inhaled Budesonide in Persons with Mild Chronic Obstructive Pulmonary Disease Who Continue Smoking
Authors: Romain A. Pauwels, Claes-Göran Löfdahl, Lauri A. Laitinen, Jan P. Schouten, Dirkje S. Postma, Neil B. Pride, Stefan V. Ohlsson
Journal: New England Journal of Medicine (1999)

Although patients with chronic obstructive pulmonary disease (COPD) should stop smoking, some do not. In a double-blind, placebo-controlled study, we evaluated the effect of the inhaled glucocorticoid budesonide in subjects with mild COPD who continued smoking. After a six-month run-in period, we randomly assigned 1277 subjects (mean age, 52 years; mean forced expiratory volume in one second [FEV1], 77 percent of the predicted value; 73 percent men) to twice-daily treatment with 400 μg of budesonide or placebo, inhaled from a dry-powder inhaler, for three years.
NONOBSTRUCTIVE LEFT MAIN CORONARY ARTERY DISEASE ON CORONARY CT ANGIOGRAPHY AND RISK FOR MYOCARDIAL INFARCTION
Authors: Joe Xie, Abhinav Goyal, Jonathon Leipsic, Briain O. Hartaigh, Daniel Berman, Matthew Budoff, Stephan Achenbach, Allison Dunning, Tracy Callister, Augustin DeLago, Hugo Marques, Ronen Rubinshtein, Mouaz H. Al-Mallah, Daniele Andreini, Filippo Cademartiri, Kavitha Chinnaiyan, Martin Hadamitzky, Gudrun Feuchtner, Yong-Jin Kim, Philipp Kaufmann, Gianluca Pontone, Gilbert Raff, Todd Villines, James Min, Leslee Shaw
Journal: Journal of the American College of Cardiology (2016)
SAT0365 Risk Evaluation of Osteonecrosis of the Jaw in Denosumab: Systematic Review of the Literature
Authors: E. Saule, E. Ricard, P. Vergne-Salle, C. Bonnet, R. Treves, P. Bertin
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Osteonecrosis of the jaw (ONJ) is a potentially serious disease described with drugs such as bisphosphonates and denosumab. <h3>Objectives</h3> The main objective of our study was to evaluate the risk of osteonecrosis of the jaw with denosumab in osteoporosis and update data in neoplasia. Secondary end points were to report the deadline of occurrence, the disease treated and the risk factors associated with ONJ. <h3>Methods</h3> Systematic literature search of articles from 2004 to February 2012 with the keyword "denosumab" on the PUBMED database (Medline), selecting randomized clinical trials languages English and French. Research was expanded secondarily with cases reports. The diagnosis of ONJ had to satisfy the definition of AAOMS (American Association of oral and Maxillofacial Surgeons) and ASBMR (American Society for Bone and Mineral Research) as exposed bone in the maxillofacial region that fails to heal after appropriate intervention over a period of 8 weeks, without history of radiation therapy or bone metastasis to the jaws and should be validated by an independent expert. <h3>Results</h3> In osteoporosis, 10 clinical trials were identified. With the dose of 60 mg every 6 months, 4 jaw osteonecrosis occurred in the FREEDOM extension study to 6 years (n = 4550) or 0.09% of patients. In neoplasia, six studies were included. With the dose of 120 mg every 4 weeks, 85 jaw osteonecrosis of 3578 patients (2.4%) occurred in the denosumab group, 26 (30%) in the first year, 72 (85%) after two years treatment. 73 patients (86%) had local risk factors, 35 (67%) had concomitant chemotherapy, 5 (16%) antiangiogenic treatment. 42 patients (49%) underwent surgical treatment limited and 5 (7%) of bone resection. Healing was achieved in 31 patients (36%). <h3>Conclusions</h3> In neoplastic disease, osteonecrosis of the jaw is common during denosumab treatment specially if there are predisposing risk factors. In osteoporosis, it remains relatively rare. <h3>Disclosure of Interest</h3> None Declared
Effect of a Low-Fat Diet on the Incidence of Actinic Keratosis
Authors: Homer S. Black, J. Alan Herd, Leonard H. Goldberg, John E. Wolf, John I. Thornby, Theodore Rosen, Suzanne Bruce, Jaime A. Tschen, John P. Foreyt, Lynne W. Scott, Suzanne Jaax, Kelly Andrews
Journal: New England Journal of Medicine (1994)

Actinic keratoses are premalignant lesions and are a sensitive and important manifestation of sun-induced skin damage. Studies in animals have shown that dietary fat influences the incidence of sun-induced skin cancer, but the effect of diet on the incidence of actinic keratosis in humans is not known.
Successful treatment of a gastric leak after bariatric surgery using endoluminal vacuum therapy
Authors: F. Seyfried, S. Reimer, A. Miras, W. Kenn, C.-T. Germer, M. Scheurlen, C. Jurowich
Journal: Endoscopy (2013)

A gastric leak after bariatric surgery is a serious complication [1]. Its successful management requires considerable experience, expertise, and a patient-tailored, multidisciplinary therapeutic approach [1]. The effectiveness of surgical re-intervention is limited by the compromised and inflamed tissue adjacent to the leak, which makes its adequate closure either difficult or impossible [1] [2]. In contrast, available endoscopic interventions, including fibrin sealing [2], over-the-scope clipping [3], and the insertion of intraluminal covered stents [1], have been shown to be good treatment options. Preliminary experience with endoluminal vacuum therapy has provided supportive evidence for the efficacy of this intervention in the management of leaks following gastroesophageal anastomoses [4] [5]. The favorable effects of this treatment may be due to the reduction in the intraluminal pressure and the marked growth of granulation tissue that it induces.
Variations in Immunogenicity of Disrupted Cells Prepared From an Adenovirus-7 Hamster Tumor Cell Line&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: Peter N. Panteleakis, Vivian M. Larson, William J. McAleer, Maurice R. Hilleman
Journal: JNCI Journal of the National Cancer Institute (1971)

Adenovirus-7 hamster tumor cells propagated in cell culture varied markedly with respect to capability to immunize against homologous transplant tumor after treatment with formaldehyde or disruption by various mechanical means. Protective vaccines employed cells for vaccine preparation or for challenge that were at passage levels comparable to those of the nonprotective vaccines. The protective vaccines were made with highly oncogenic cells, while the cells used for nonprotective vaccines varied, ranging from weakly to highly oncogenic. The basis for the differences in immunogenicity of the vaccines is not known. However, all protective vaccines were prepared from the descendants of a single vial of frozen parent-cell seed stock, while the nonprotective vaccines came from descendants of other frozen vials of the same parent seed. Selection of qualitatively different progeny from the parent cell population appeared to have taken place. Possible difference in the kind of immune response e.g., cell-mediated compared with humoral antibody (tumor-enhancing), is being investigated.
736 NOVEL EFFECTOR OF HBV CAPSID ASSEMBLY REDUCES THE ACTIVITY OF cccDNA AND INTERACTS SYNERGISTICALLY WITH NUCLEOSIDE ANALOGS IN THE HUMAN HEPATOCYTES
Authors: L. Bassit, T. Ozturk, S. Tao, S.R. Boucle, M. Ehteshami, A. Zlotnick, M.A. Feitelson, R.F. Schinazi
Journal: Journal of Hepatology (2013)
GE-20 * GENOMIC CHARACTERIZATION OF BREAST CANCER BRAIN METASTASES
Authors: S. Michelhaugh, A. Bollig-Fischer, B. Alosh, R. Ali-Fehmi, S. Mittal
Journal: Neuro-Oncology (2014)

BACKGROUND: The incidence of central nervous system metastasis from primary breast cancer has steadily increased with introduction of more effective molecular-targeted therapies resulting in improved long-term survival. Current standard-of-care treatment modalities for CNS metastases include microsurgical resection, whole-brain radiation therapy, and stereotactic radiosurgery, either alone or in combination. There are currently no FDA-approved drugs with an indication for breast cancer brain metastases. Clearly, there is a dire need to identify biomarkers permitting earlier and accurate diagnosis of CNS metastases, development of prevention strategies in high-risk individuals, and establishing more effective treatment options such as targeted systemic and intrathecal therapies. METHODS: Extracted DNA from metastatic brain tumors (MBTs) and matched tissues from primary breast tumors was quantified and array comparative genomic hybridizations (aCGH) were performed with Agilent SurePrint arrays (G3 ISCA CGH + SNP 180K) using a commercially-available, genetically-normal female DNA standard. Bioinformatics analysis was performed using Agilent CytoGenomics Edition 2.5.8.1. Data were filtered against the Cancer Gene Census (Wellcome Trust Sanger Institute) to identify genes with well-characterized roles in cancer. RESULTS: From genomic copy number data analysis tailored to uncover the most frequent gene aberrations in breast cancer MBTs, we identified that MYC oncogene amplification was among the most common. Pathway analysis of the analyzed gene set of recurring gene aberrations identified the Human Embryonic Stem Cell Pluripotency pathway as being over-represented. The genes in this pathway showing copy number gain include NTRK1, PIK3CA and SOX2. Direct comparisons of MBTs with their matched primary tumor (n = 4) revealed a range of examples for highly similar and divergent patterns of gene aberrations. In one case ERBB2 was confirmed to be in the MBT, and not in the primary specimen. CONCLUSIONS: Genomic analyses of matched primary and MBTs provide new direction for the development of targeted therapeutics for breast cancer brain metastases.
ESFINTEROTOMIA ENDOSCOPICA MAS DILATACION CON BALON (DB) FRENTE A ESFINTEROTOMIA ENDOSCOPICA (EE) EN EL TRATAMIENTO DE LA COLEDOCOLITIASIS
Authors: I Ortiz, A Del Val, M Bustamante, N Moreno, E Moreno-Osset
Journal: Endoscopy (2010)

Objetivos: Evaluar la eficacia y complicaciones de la DB y compararla con la EE en el tratamiento endoscópico de la coledocolitiasis