tbuckley/cabot-search huggingface dataset:
Small Cell Lung Cancer Screen of Oncology Drugs, Investigational Agents, and Gene and microRNA Expression
Authors: Eric Polley, Mark Kunkel, David Evans, Thomas Silvers, Rene Delosh, Julie Laudeman, Chad Ogle, Russell Reinhart, Michael Selby, John Connelly, Erik Harris, Nicole Fer, Dmitriy Sonkin, Gurmeet Kaur, Anne Monks, Shakun Malik, Joel Morris, Beverly A. Teicher
Journal: JNCI Journal of the National Cancer Institute (2016)

Background: Small cell lung carcinoma (SCLC) is an aggressive, recalcitrant cancer, often metastatic at diagnosis and unresponsive to chemotherapy upon recurrence, thus it is challenging to treat. Methods: Sixty-three human SCLC lines and three NSCLC lines were screened for response to 103 US Food and Drug Administration–approved oncology agents and 423 investigational agents. The investigational agents library was a diverse set of small molecules that included multiple compounds targeting the same molecular entity. The compounds were screened in triplicate at nine concentrations with a 96-hour exposure time using an ATP Lite endpoint. Gene expression was assessed by exon array, and microRNA expression was derived by direct digital detection. Activity across the SCLC lines was associated with molecular characteristics using pair-wise Pearson correlations. Results: Results are presented for inhibitors of targets: BCL2, PARP1, mTOR, IGF1R, KSP/Eg5, PLK-1, AURK, and FGFR1. A relational map identified compounds with similar patterns of response. Unsupervised microRNA clustering resulted in three distinct SCLC subgroups. Associating drug response with micro-RNA expression indicated that lines most sensitive to etoposide and topotecan expressed high miR-200c-3p and low miR-140-5p and miR-9-5p. The BCL-2/BCL-X L inhibitors produced similar response patterns. Sensitivity to ABT-737 correlated with higher ASCL1 and BCL2. Several classes of compounds targeting nuclear proteins regulating mitosis produced a response pattern distinct from the etoposide response pattern. Conclusions: Agents targeting nuclear kinases appear to be effective in SCLC lines. Confirmation of SCLC line findings in xenografts is needed. The drug and compound response, gene expression, and microRNA expression data are publicly available at http://sclccelllines.cancer.gov .
Viruses From South American Monkeys: Ultrastructural Studies&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: N. W. King, M. D. Daniel, H. H. Barahona, L. V. Meléndez
Journal: JNCI Journal of the National Cancer Institute (1972)

Viruses From South American Monkeys: Ultrastructural Studies Get access N. W. King, N. W. King New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar M. D. Daniel, M. D. Daniel New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar H. H. Barahona, H. H. Barahona New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar L. V. Meléndez L. V. Meléndez New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 273–290, https://doi.org/10.1093/jnci/49.1.273 Published: 01 July 1972
Granular Cell Myoblastoma of the Esophagus
Authors: S S Tsung, P G Mavrelis, J S Tsung
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Water excretion and plasma vasopressin in psychotic disorders
Authors: R Emsley, A Potgieter, F Taljaard, G Joubert, R Gledhill
Journal: American Journal of Psychiatry (1989)

To investigate the pathogenesis of water intoxication in psychotic disorders, a standard water load test was given to 23 unmedicated patients with schizophrenic or schizoaffective disorders. Levels of plasma arginine vasopressin were measured concurrently. Compared with 28 healthy volunteers, the psychotic patients had significantly smaller cumulative urine output and higher minimum urine osmolalities. Patients whose current illness had lasted less than 24 weeks exhibited the most severe antidiuretic state and also had the highest plasma arginine vasopressin levels. Water intoxication in acute exacerbations of psychosis may develop as a result of impaired excretory mechanisms.
Adenocarcinoma arising from ectopic gastric mucosa in an esophageal inlet patch: treatment by endoscopic submucosal dissection
Authors: Andreas Probst, Tina Schaller, Helmut Messmann
Journal: Endoscopy (2015)

A 62-year-old man was referred for further diagnostic work-up and treatment of a focal lesion within a large area of ectopic gastric mucosa (EGM) in the proximal esophagus. The lesion was diagnosed during an upper gastrointestinal endoscopy which had been performed because of suspected gastroesophageal reflux disease.
AB0016 Retrospective Cohort Study of Systemic Lupus Erythematosus and Disease Subphenotypes in European Populations: Results from Gapaid Project
Authors: O. Ruiz-Larrañaga, P. Migliorini, M. Uribarri, L. Czirják, M.C. Alcaro, J. del Amo, M. Iriondo, S. Escorza-Treviño, A. Estonba
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The GAPAID (Genes And Proteins for AutoImmunity Diagnostics) consortium was created within the European Union9s Seventh Framework Programme for Research and Technological Development (FP7), with the aim of validating gene and protein biomarkers for autoimmune diseases such as systemic lupus erythematosus (SLE). This is an autoimmune disease characterized by a loss of tolerance to self-antigens, inflammation and dysregulated immune responses leading to multi-organ damage and affecting predominantly women (1). The wide spectrum of clinical manifestations shown by the disease complicates its diagnosis, treatment and research (2). Epidemiological studies suggest strong contribution of genetic factors in the pathogenesis of the disease and many SLE risk <i>loci</i> have been identified in several genome-wide association studies (GWAS) and other association studies in the last decades (3). <h3>Objectives</h3> To perform a replication study for several previously reported SLE susceptibility <i>loci</i> in an independent European sample and to assess their specificity with the different subphenotypes of the disease. <h3>Methods</h3> Previously associated 49 single nucleotide polymorphisms (SNP) were typed in a cohort of 208 SLE patients and 152 controls from Rheumatology Units of University Hospital of Pisa (Italy) and University of Pécs Medical Center (Hungary). Regression analyses were performed focused on the confirmation of disease susceptibility <i>loci</i> and identification of specific genes for age onset, renal, neurological and skin involvement, and presence of arthritis, secondary Sjögren syndrome and secondary antiphospholipid syndrome (APS). <h3>Results</h3> Previously described risk alleles from <i>HLA, IRF5, BLK, ITGAM</i>, and <i>IRF8</i><i>loci</i> have been identified (<i>P</i> value &lt;0.05). In addition, several genes appear to be related with the different analized subphenotypes. Four of them could be highlighted due to their strongest <i>P</i> value: the risk effect of SNP rs5754217 (<i>UBE2L3</i>) for skin involvement (<i>P</i> value =0.0004), that of rs907715 (<i>IL21</i>) and rs3093030 (<i>ICAM1-ICAM4-ICAM5</i>) for haematological disorders (<i>P</i> value =0.0031 and <i>P</i> value =0.0010, respectively), and rs4240671 (<i>XKR6</i>) for CNS involvement (<i>P</i> value =0.0085). <h3>Conclusions</h3> Overall, results from GAPAID project are consistent with previously established associations for <i>HLA, IRF5, BLK, ITGAM</i>, and <i>IRF8</i> SLE susceptibility <i>loci</i> and report for the first time several subphenotype-specific associations. <h3>References</h3> Chung et al. PLoS Genet 2011; 7:e1001323. Eisenberg J. Autoimmun 2009; 32: 223–230. Rullo and Tsao. Ann Rheum Dis 2013; 72(Suppl 2): 56–61. <h3>Disclosure of Interest</h3> None declared
Brief Communication: Topologic Forms of Mitochondrial DNA in AKR Mice
Authors: Deborah C. Newman, Joseph V. Scaletti
Journal: JNCI Journal of the National Cancer Institute (1975)

Circular dimer forms of mitochondrial DNA were found in leukemic and preleukemic AKR mice but not in nonleukemic animals. There was a positive correlation between the presence of circular dimers and progression of the disease, the leukemic mice having the greatest evidence of circular dimers. This finding suggested that the occurrence of early subcellular changes is an important cellular modification in the leukemogenic process.
FRI0562 Ultrasound Enthesitis in Primary Care Psoriasis Patients with Musculoskeletal Complaints
Authors: M. van der Ven, M. Karreman, A. Weel, I. Tchetverikov, M. Vis, T. Nijsten, M. Hazes, J. Luime
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Psoriasis patients with enthesitis can classify as psoriatic arthritis since the introduction of the CASPAR classification criteria in 2006. However, clinical assessment of the entheses could be challenging. In addition, the presence of a tender enthesis is not necessarily indicative for underlying inflammatory disease as it could be related to overuse, metabolic disease or ageing. Therefore, we need a better way to identify the inflammatory component of entheseal involvement in psoriasis. To detect these inflammatory components in the entheses, ultrasound (US) examination can be used to identify inflammatory disease at the entheses. <h3>Objectives</h3> Our aims were to determine the prevalence of US abnormalities among psoriasis patients in primary care and to determine the concordance of clinical and US information at individual entheseal sites. <h3>Methods</h3> Adult patients with psoriasis were invited to participate in the SENSOR study. Patients who reported pain in joints, entheses or the lower back were eligible for clinical evaluation. If physical examination indicated a painful enthesis on the LEI/MASES or if arthritis was present, US examination of the entheses was performed. The six entheses of the Madrid Sonographic Enthesis Index (MASEI) and the lateral epicondyle tendon insertion (elbow) were evaluated according to the MASEI scoring system. Enthesitis was defined as US inflammation (positive power Doppler (PD) signal or a thickened enthesis of the plantar fascia) in combination with one clinical feature at the same enthesis. Structural changes detected by ultrasound were calcifications, increased thickness, irregular fibre structure and erosions. <h3>Results</h3> Of 524 patients who participated in the SENSOR study, 111 patients were assessed both by physical examination and by US. In 106 (95%) patients we detected US abnormalities. In 56 (50%) patients we found structural changes without indication for inflammatory disease. In 50 (45%) patients we found US abnormalities indicating inflammatory disease at the enthesis (positive PD: n=35; thickened plantar fascia: n=15). When we combined the US data with the clinical information, 36% of US inflammatory disease were confirmed [Figure 1]. <h3>Conclusions</h3> We found US abnormalities in 95% of the primary care psoriasis patients with musculoskeletal complaints, which is a combination of both structural and inflammatory US components. In 45% of primary care psoriasis patients we observed US inflammatory disease, which was confirmed in 36% of the patients by clinical information. <h3>Acknowledgements</h3> This study was financially funded by an investigator-initiated grant from Pfizer bv. <h3>Disclosure of Interest</h3> None declared
Adhere, Degrade, and Move: The Three-Step Model of Invasion
Authors: Lance A. Liotta
Journal: Cancer Research (2016)

Abstract Experimental work during the period 1975–1986 revealed the crucial importance of the extracellular matrix (ECM) in tumor cell invasion and metastasis, and culminated in the three-step hypothesis of invasion. The first step is tumor cell attachment to the ECM. The second step is proteolytic degradation of the ECM, led by advancing protruding actin-rich pseudopods. The third step is migration of the tumor cell body through the remodeled matrix. This mechanistic scheme is widely accepted and continues to generate insights related to the large number of molecules, inside and outside invading cells, which all play a role in each of the three steps. Understanding the interaction of the tumor cells with the ECM has never been more clinically important. The ECM is not just a passive mechanical scaffold. Instead, the ECM is an active participant in neoplastic and physiologic invasion, and acts as an information highway, an immune sanctuary, and a storage depot supporting tumor growth and drug resistance. Cancer Res; 76(11); 3115–7. ©2016 AACR. See related article by Liotta, Cancer Res 1986;46:1–7. Visit the Cancer Research 75th Anniversary timeline.
FRI0440 Increased Messenger RNA Levels of the Mesenchymal Cadherin-11 in the Peripheral Blood Correlate with Diffuse Skin Involvement in Systemic Sclerosis
Authors: P. Christopoulos, V.-K. Bournia, S. Panopoulos, A. Vaiopoulos, M. Koutsilieris, P. Sfikakis
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The mesencymal cadherin-11 is a cell-cell adhesion molecule also involved in cellular migration and invasion. Experimental studies have implicated a pathogenetic role of this molecule in inflammatory arthritis and in fibrosing conditions. Moreover, in the skin of patients with the prototypic human fibrotic disease, namely systemic sclerosis (SSc), cadherin-11 is hyper-expressed on dermal fibroblasts and resident macrophages, whereas the increased respective mRNA levels correlate with the modified Rodnan skin thickness scores (1). <h3>Objectives</h3> To examine whether cadherin-11 gene expression can be also identified in cells that circulate in SSc peripheral blood. <h3>Methods</h3> Cadherin-11 mRNA was quantified by real-time reverse transcription-polymerase chain reaction as previously described (2), in 3 ml blood samples obtained from 71 SSc patients (aged 53±2 years, 65 women) and 35 control non-SSc patients with Raynaud9s phenomenon, without active synovitis at the time of sampling. <h3>Results</h3> Cadherin-11 mRNA transcripts were detected in blood samples from 39% of patients with diffuse SSc, versus 16% in those with limited SSc, versus 6% and 16% in patients with idiopathic or associated with other connective tissue diseases Raynaud9s phenomenon, respectively (p=0.049). Cadherin-11 mRNA levels in SSc patients were increased by 3.74-fold comparing to controls (p=0.036). By multivariate logistic regression analysis we found that diffuse skin involvement correlated with cadherin-11 mRNA positivity (p=0.028), independently of age, gender, disease duration, lung involvement, digital ulcers, inflammatory indices or anti-Scl-70 autoantibody presence. A similar independent correlation of diffuse SSc was also observed with increased (considered arbitrarily as ≥3-fold of average non-SSc levels) individual levels of cadherin-11 mRNA (p=0.011). <h3>Conclusions</h3> Cadherin-11 is hyper-expressed at the mRNA level in the peripheral blood of patients with diffuse SSc, further supporting the notion that cadherin-11 may be a legitimate therapeutic target. Studies on the origin and possible pathogenic function of these circulating cells may shed light into the complex pathogenesis of SSc. <h3>References</h3> Wu M, et al. Identification of cadherin-11 as a mediator of dermal fibrosis and possible role in systemic sclerosis. Arthritis Rheum 2014;66(4):1010-21. Sfikakis PP, et al. Cadherin-11 mRNA transcripts are frequently found in rheumatoid arthritis peripheral blood and correlate with established polyarthritis. Clin Immunol. 2014;155(1):33-41. <h3>Disclosure of Interest</h3> None declared
FRI0637-HPR Measurement of Fatigue in RA: The Construct Validity of a Multidimensional Computerized Adaptive Test
Authors: S. Nikolaus, C. Bode, E. Taal, H. Vonkeman, C. Glas, M. van de Laar
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Computerized adaptive testing (CAT) provides the possibility to measure patient reported outcomes precisely at an individual level. Items are selected from a large item pool, based on the previous answer of a patient. Multidimensional CAT has the further advantage that simultaneous measurement of multiple dimensions increases the efficiency of the adaptive item selection procedure. Thereby comprehensive measurement across different aspects of fatigue becomes possible. <h3>Objectives</h3> We developed a multidimensional CAT for fatigue in RA. The CAT Fatigue RA was constructed based on a previously calibrated item bank and contains 196 items and three dimensions: severity, impact and variability of fatigue. Aim of this study was the construct validation of the CAT Fatigue RA. <h3>Methods</h3> The CAT was administered to 166 patients with RA. They also completed a traditional, multidimensional fatigue questionnaire (Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional Questionnaire; BRAF-MDQ) and the 36-item short-form (SF-36) in order to examine the CAT9s construct validity. Furthermore, comprehensive use of the item bank, measurement precision and score distribution were investigated. <h3>Results</h3> Construct validity was supported for the dimensions "severity" and "impact". Respectively 87% of the correlations with the well-established questionnaires were as expected. For the dimension "variability", 53% of the hypothesised relations were found. Most items (89%) have been selected for the CAT administrations between one and 137 times. Measurement precision was excellent for the "severity" and "impact" dimensions with more than 90% of the CAT administrations having a standard error below 0.32. On the "variability" dimension 90% of the standard errors lay below 0.44 what still indicates a good reliability. No floor- or ceiling effects were found on the three dimensions. <h3>Conclusions</h3> The CAT Fatigue RA showed good construct validity and excellent measurement precision on the dimensions "severity" and "impact". The dimension "variability" had less ideal measurement characteristics, pointing to the need to recalibrate the CAT item bank with a two-dimensional model. Finally, the CAT Fatigue RA can be used in daily clinical practice and for research purposes. <h3>References</h3> Nikolaus S, Bode C, Taal E, Vonkeman H, Glas CAW, van de Laar MAFJ. Acceptance of new technology: a usability test of a computerized adaptive test for fatigue in rheumatoid arthritis. Journal of Medical Internet Research Human Factors 2014; 1(1):e4. doi 10.2196/humanfactors.3424. Nikolaus S, Bode C, Taal E, Vonkeman H, Glas CAW, van de Laar, MAFJ (in press).Working mechanism of a multidimensional computerized adaptive test for fatigue in rheumatoid arthritis. Health and Quality of Life Outcomes. <h3>Disclosure of Interest</h3> None declared
FRI0590 Observation of Images During Ultrasound-Guided Procedures Improves the Patient Experience
Authors: I. Sahbudin, J. Bell, K. Kumar, K. Raza, A. Filer
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Intra-articular and soft tissue steroid injections are common procedures in Rheumatology and are taking the place of fluoroscopic or CT-guidance injection. However, little is known about patient views on ultrasound-guided steroid injections and whether observing images during the procedure has a positive or negative impact. <h3>Objectives</h3> We conducted a pilot study to quantitatively describe patients9 view of US-guided procedures. <h3>Methods</h3> 50 survey questionnaires with balanced-likert scales were distributed to Rheumatology patients who underwent an US-guided procedure in the Rheumatology Department at Sandwell and West Birmingham Hospitals NHS Trust between January 2011 and January 2012. All patients were able to view the scanner screen and the procedure and images were explained by the operator. Survey receipt was concluded in April 2012 relating to a post injection period ranging between 4–16 months. Of 50 questionnaires distributed, 30 (60%) were returned and 26 (50%) were completed and included for data analysis. <h3>Results</h3> A total of 33 joints/tendon regions were injected in 26 patients [12; hand, 9; wrist, 2; elbow, 3; knee, 5; feet]. All patients felt that observing the US images during the US-guided procedure was helpful. 85% of the patients felt that observing US images during the procedure reduced anxiety with no individuals describing heightened anxiety. 92% of patients felt that observing the US images in real-time helped them to tolerate the procedure better and the same proportion of patients felt seeing the images increased their confidence that the pain source had been identified. 62% of patients felt that observing the US images provides additional information that improves understanding of the procedure. Amongst those who had a non-guided injection previously (n=19), 68% of patients felt that US-guided injection was more or much more effective compared to traditional injection without US. <h3>Conclusions</h3> Observing images during US-guided procedure improves patients9 experience and has no negative impact. This is the first study to describe the benefits of visually demonstrating pathology to patients via ultrasound; further work is required to investigate this in a larger cohort. <h3>Disclosure of Interest</h3> None declared
Acute Renal Insufficiency after Ingestion of a Gall-Bladder Dye
Authors: William B. Blythe, James W. Woods
Journal: New England Journal of Medicine (1961)

IN 1959 Rene and Mellinkoff1 reported 2 cases of A renal insufficiency that followed the oral administration of double doses of iopanoic acid.§ To our knowledge, no similar cases have been reported, which emphasizes the rarity of renal complications after the ingestion of cholecystographic mediums. The purpose of this paper is to report a case of acute renal insufficiency subsequent to the administration of a double dose of bunamiodyl.¶ Bunamiodyl, 3-(3-butyrylamino-2,4,6-tri-iodophenyl) -2-ethyl sodium acrylate, is the newest of the gall-bladder dyes and, according to available reports,2 , 3 is stated to be more effective than the older mediums in that better visualization . . .