tbuckley/cabot-search huggingface dataset:
Single Question Can Identify Youth at Risk for Alcohol Use Disorder
Authors: Julie A. Jacob
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Molecular heterogeneity in complete cytogenetic responders after interferon-α therapy for chronic myelogenous leukemia: low levels of minimal residual disease are associated with continuing remission
Authors: Andreas Hochhaus, Andreas Reiter, Susanne Saußele, Anja Reichert, Michael Emig, Jaspal Kaeda, Beate Schultheis, Ute Berger, Patricia C. A. Shepherd, Norman C. Allan, Rüdiger Hehlmann, John M. Goldman, Nicholas C. P. Cross
Journal: Blood (2000)
Statistical inference of a convergent antibody repertoire response to influenza vaccine
Authors: Nicolas B. Strauli, Ryan D. Hernandez
Journal: Genome Medicine (2016)

Vaccines dramatically affect an individual's adaptive immune system and thus provide an excellent means to study human immunity. Upon vaccination, the B cells that express antibodies (Abs) that happen to bind the vaccine are stimulated to proliferate and undergo mutagenesis at their Ab locus. This process may alter the composition of B cell lineages within an individual, which are known collectively as the antibody repertoire (AbR). Antibodies are also highly expressed in whole blood, potentially enabling RNA sequencing (RNA-seq) technologies to query this diversity. Less is known about the diversity of AbR responses across individuals to a given vaccine and if individuals tend to yield a similar response to the same antigenic stimulus.Here we implement a bioinformatic pipeline that extracts the AbR information from a time-series RNA-seq dataset of five patients who were administered a seasonal trivalent influenza vaccine (TIV). We harness the detailed time-series nature of this dataset and use methods based in functional data analysis (FDA) to identify the Abs that respond to the vaccine. We then design and implement rigorous statistical tests in order to ask whether or not these patients exhibit a convergent AbR response to the same TIV.We find that high-resolution time-series data can be used to help identify the Abs that respond to an antigenic stimulus and that this response can exhibit a convergent nature across patients inoculated with the same vaccine. However, correlations in AbR diversity among individuals prior to inoculation can confound inference of a convergent signal unless it is taken into account.We developed a framework to identify the elements of an AbR that respond to an antigen. This information could be used to understand the diversity of different immune responses in different individuals, as well as to gauge the effectiveness of the immune response to a given stimulus within an individual. We also present a framework for testing a convergent hypothesis between AbRs; a hypothesis that is more difficult to test than previously appreciated. Our discovery of a convergent signal suggests that similar epitopes do select for antibodies with similar sequence characteristics.
Brain neurotransmitter changes in three patients who had a fatal hyperthermia syndrome
Authors: S J Kish, R Kleinert, M Minauf, J Gilbert, G F Walter, C Slimovitch, E Maurer, Y Rezvani, R Myers, O Hornykiewicz
Journal: American Journal of Psychiatry (1990)

The authors examined the autopsied brains from three patients who had a fatal hyperthermia syndrome. There was marked hypothalamic noradrenaline depletion in all three patients, severe brain choline acetyltransferase deficiency with nucleus basalis cell loss in two patients, and mild to moderate brain choline acetyltransferase loss in one patient. Striatal dopamine metabolite/dopamine ratio was below normal in two patients and not elevated, as would be expected after short-term neuroleptic administration, in the third. This suggests that reduced capability (aggravated by the cholinergic deficit) of the nigrostriatal dopamine system to respond adequately to stress and/or neuroleptic-induced receptor blockade may be important in the development and course of fatal hyperthermia syndrome.
Studies in Thailand of the Vertical Transmission of HIV
Authors: S Wongchoosri, M Wera-arpachai, V Gulgolgarn, W Ketsararat, N Sittisombut, S Tovanabutra
Journal: New England Journal of Medicine (1998)

This letter notes that several international institutions are collaborating on an observational study of maternal-infant transmission of HIV conducted in Thailands Lampang Hospital.  The purpose of the study is to correlate viral and immunologic data from mucosal and systemic specimens with transmission data.  The study is not a placebo-controlled study and it seeks vital information for understanding vertical transmission of HIV subtype E.  At the time the study was initiated the use of zidovudine for reducing vertical transmission was not the standard of care nor was zidovudine available through the Thai Ministry of Health.  Thus availability of the drug solely through the research study would have created an unethical inducement for participation.  On the other hand provision of powdered milk is an established standard of care and all participants are provided adequate milk.  From the time that the Ministry of Health began to assess the effect of zidovudine on vertical transmission of HIV type 1 all subjects in the observational study who met the eligibility criteria for treatment also received zidovudine.
EMOTIONAL AND PSYCHOLOGICAL FACTORS IN EPILEPSY
Authors: WILLIAM F. CAVENESS
Journal: American Journal of Psychiatry (1955)

Two cases are presented to illustrate the importance of emotional and psychological factors in epilepsy. Attention is directed to the personality changes that arise as a reaction to seizures. It is noted that emotional stress may act as a precipitant to individual seizures. Finally, it is pointed out that elements from past experience, of particular emotional significance, may be incorporated into the clinical pattern of seizures that arise from a discharging lesion in the temporal lobe of the brain.
Abstract B48: The effects of different types of hypoxia on tumor progression in breast cancer
Authors: Anna Chen, Jaclyn Sceneay, Nathan Gödde, Erik Thompson, Patrick Humbert, Andreas Möller
Journal: Cancer Research (2016)

Abstract Hypoxia, the state of low oxygen conditions, occurs frequently in solid tumors and is a poor prognostic factor. The expression of Hif-1α,the main mediator of the hypoxic response pathway, and the subsequent up-regulation of its target genes have been implicated in tumor growth, invasion, angiogenesis, therapy resistance and metastasis. There are two forms of hypoxia present in a growing tumor: chronic hypoxia (caused by limitations in oxygen diffusion from abnormal tumor vasculature) and intermittent hypoxia (caused by the aberrant, repeated and temporary closing and re-opening of blood vessels, leading to fluctuations in oxygen supply). This study investigates the phenotypes endowed by different forms of hypoxia that mediate metastatic potential in a syngeneic mouse model of breast cancer. By exposing murine breast cancer cells to 9 days of 20% O2 (normoxia), 1% O2 (chronic hypoxia) or alternating 24 hour cycles in 20% O2 and 1% O2 (intermittent hypoxia), we observe that intermittent hypoxia produces tumor cells with greater metastatic potential. These treatments produce no difference in primary tumor growth when orthotopically injected into the mammary fat pad of female C57Bl/6 mice. However, intermittent hypoxia-treated cells give rise to a greater number of and larger lung metastases when injected intravenously via the tail-vein of female C57Bl/6 mice. Intermittent hypoxia, but not chronic hypoxia, up-regulated the expression of genes that predict lung metastasis in breast cancer, endowed cells with an enhanced ability for anchorage-independent growth and produced greater clonal diversity. Furthermore, intermittent hypoxia also caused a switch to glycolysis in cells and induced a pro-tumorigenic, immunosuppressive secretory profile in vitro. Finally, intermittent hypoxia up-regulated the expression of mammary stem cell genes, increased expression of stem cell marker Sca-1 as well as CD14, and generated tumor-initiating cells at a higher frequency as evidenced by in vivo limiting dilution assays. This work demonstrates that intermittent hypoxia enhances metastatic seeding and outgrowth by priming cells intrinsically to metastasize, while activating co-operating factors that act extrinsically to form a permissive, immunosuppressive microenvironment. By delineating the contributions of different forms of hypoxia to metastasis, critical molecular mediators can be identified in aid of the development of efficacious therapies that could inhibit, prevent or cure metastatic disease. Citation Format: Anna Chen, Jaclyn Sceneay, Nathan Gödde, Erik Thompson, Patrick Humbert, Andreas Möller. The effects of different types of hypoxia on tumor progression in breast cancer. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr B48.
"Moonies" get married: a psychiatric follow-up study of a charismatic religious sect
Authors: M Galanter
Journal: American Journal of Psychiatry (1986)

A 3-year follow-up of longtime engaged members of the Unification Church revealed remarkable compliance with the sect's unusual marital commitments. Of 305 subjects, 95% were still active in the church and 85% had been married in the interim to mates designated by their religious leader. Their scores on a measure of psychological well-being remained below those of the general population, and members who deviated from the sect's expectations showed even greater distress. Furthermore, analysis revealed that affiliative ties with the sect apparently counteracted the distress produced by the unusual marital experience and help to explain compliance with the sect's unusual behavioral norms.
PTU-046 The prevalence of extraintestinal manifestations associated with inflammatory bowel disease differs between ethnic groups in the UK
Authors: D G Walker, H R T Williams, T R Orchard
Journal: Gut (2010)

<h3>Introduction</h3> The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, Bangladesh and Sri Lanka) to the UK. Currently 2.33 million South Asians live in the UK and 0.86 million live in London. There have been no previous studies reporting the prevalence of extraintestinal manifestations (EIMs) associated with IBD in this population. <h3>Methods</h3> The aim of the study was to establish whether there are differences in the prevalence of EIMs in a cohort of UK South Asian IBD patients compared with a British Caucasian IBD cohort. The medical notes of IBD patients attending five hospitals in North West London were monitored for a 2-year period between 2007 and 2009 to identify South Asian patients under active follow-up. IBD patients with any EIMs were recorded. EIMs were defined as joint complications (Type 1 or 2 peripheral arthropathy, ankylosing spondylitis and sacroiliitis), skin complications (erythema nodosum and pyoderma gangrenosum), anterior uvetitis and primary sclerosing cholangitis. The data were compared with an established database of British Caucasian IBD patients (609 ulcerative colitis (UC): 560 Crohn9s disease (CD)) using the χ<sup>2</sup> test. <h3>Results</h3> A total of 371 South Asian IBD patients were studied (271 UC: 100 CD). Forty-one patients (11%) had at least one EIM. Twenty-five (9.2%) of the South Asian UC population had an EIM associated with IBD. This was significantly lower than the Caucasian population (112/609; 18.4%) (<i>P</i>=0.0005). The most common EIM in South Asians UC patients was type 1 (large joint) peripheral arthritis (7/271; 2.6%). EIMs were also more common in the Caucasian CD cohort (148/560; 26.4%) than the South Asian CD cohort (16/100; 16%) (<i>P</i>=0.03). Erythema nodosum was the most common EIM in South Asian CD patients (5/100; 5%). <h3>Conclusion</h3> This is the first study of EIMs in a UK South Asian IBD cohort and shows that they are significantly less common compared to a British Caucasian IBD population. As several studies have reported an association between EIMs and <i>HLA</i> gene polymorphisms in Caucasians, differences in the prevalence of EIMs may reflect variation in <i>HLA</i> polymorphisms between the groups. Further genetic studies are required to determine the answer.
Radioiodide-Concentrating Ability of Transplantable Tumors of the Thyroid Gland in C3H Mice
Authors: S. H. Wollman, R. O. Scow, H. P. Morris
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Radioiodide-Concentrating Ability of Transplantable Tumors of the Thyroid Gland in C3H Mice Get access S. H. Wollman, S. H. Wollman National Cancer Institute and National Institute of Arthritis and Metabolic Diseases,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar R. O. Scow, R. O. Scow National Cancer Institute and National Institute of Arthritis and Metabolic Diseases,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. P. Morris H. P. Morris National Cancer Institute and National Institute of Arthritis and Metabolic Diseases,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 593–605, https://doi.org/10.1093/jnci/14.3.593 Published: 01 December 1953 Article history Received: 17 June 1953 Published: 01 December 1953
Surveillance of screening for hepatitis C through the laboratory network RENA-VHC, France, 2000-2001
Authors: C Meffre, C Larsen, A Perin, L Bouraoui, E Delarocque Astagneau
Journal: Eurosurveillance (2003)

Over the period 2000-2001, 189 private or hospital laboratories scattered throughout France participated to the laboratory network RENA-VHC. A total of 759 591 serologies (screening tests and validation of screening tests) were performed, revealing an increase of 10% between 2000 and 2001. The rate of the amount of tests to validate screening found positive over the overall amount of tests performed was 1.2% in 2000 and 1.0% in 2001. This suggests that screening covered more people with little risk of acquiring HCV infection. The per-sons confirmed HCV positive were predominantly men (sex ratio 1.5) of which 31% were30 to 39 years of age.
Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot
Authors: N. Zulehner, B. Nagl, P. Briza, A. Roulias, B. Ballmer-Weber, G. J. Zlabinger, F. Ferreira, B. Bohle
Journal: Allergy (2016)

In contrast to other Bet v 1-related food allergens, the major carrot allergen, Dau c 1, has been suggested to induce food allergy independently from Bet v 1. As T cells are crucial in the sensitization process, we sought to characterize the T-cell response to Dau c 1 and its cross-reactivity with Bet v 1.Dau c 1-specific T-cell lines (TCL) and clones (TCC) established from PBMC of birch pollen-allergic patients with carrot allergy were analyzed for reactivity to Bet v 1, epitope specificity, allergen-induced cytokine secretion, and expression of integrins α4β7 and α4β1, critical for gut and lung homing, respectively. mRNA expression of GATA3 and Tbet was analyzed in sorted CD3+ CD4+ CFSElow cells proliferating upon stimulation of PBMC with Dau c 1 or Bet v 1. Dau c 1 was incubated with endolysosomal proteases, and the resulting fragments were identified by mass spectrometry.Among 14 distinct T-cell-activating regions, Dau c 1139-153 was recognized by 55% of the patients. Only 6 of 15 (40%) Dau c 1-specific TCL and 9 of 21 (43%) TCC reacted with Bet v 1. Bet v 1-nonreactive TCC were mainly Th1-like and showed a higher expression of the integrin β7 and a significantly lower expression of the integrin β1 than Bet v 1-positive TCC. A Th1-like response was also detected in Dau c 1-reactive CD3+ CD4+ CFSElow cells. Full-length Dau c 1 was still detectable after 48 h of endolysosomal degradation. Proteolytic fragments of Dau c 1 matched its T-cell-activating regions.Dau c 1 displays several characteristics of sensitizing allergens, namely a major T-cell-activating region, low susceptibility to endolysosomal degradation, and induction of a Bet v 1-independent T-cell response. These cellular insights confirm that the major carrot allergen has a special status among Bet v 1-related food allergens.
Oncogenic Simian Adenoviruses. V. Recovery of Infectious Virus From Intracranial Tumor Cells Induced by Simian Adenovirus 7&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Malcolm Slifkin, Ph.D., Leonard P. Merkow, M.D., Ph.D., Matias Pardo, Norbert P. Rapoza, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1969)

Infectious and oncogenic virus was recovered from cell cultures derived from hamster intracranial neoplasms induced by simian adenovirus 7 (SA7). The virus isolate had morphological, biological, and biophysical characteristics consistent with SA7. It was indistinguishable from SA7 by the neutralization test. The SA7 T antigen was demonstrated in LLC-MK2 cells infected with the viral isolate and in subcutaneous neoplastic cells induced by this isolate. Annulate lamellae were observed in neoplastic cells induced by this isolate.
Case 33-1979
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Michael J. Barza, Karl H. Proppe
Journal: New England Journal of Medicine (1979)

Presentation of CaseA 63-year-old man was admitted to the hospital because of fever and hip pain.A subtotal gastrectomy had been performed many years earlier because of a peptic ulcer. Postoperative vitamin B12 deficiency had been treated with periodic injections. Eight years before admission exertional dyspnea developed. Three years later a physician heard a murmur and referred him to this hospital. Cardiac catheterization revealed mitral regurgitation, which was attributed to ruptured chordae tendineae. A thoracotomy disclosed prolapse of the posterior leaflet of the mitral valve and rupture of chordae tendineae. A Starr — Edwards ball-valve prosthesis was implanted. . . .
Letter to the editor: Screening for Coxiella burnetii infection during pregnancy: pros and cons according to the Wilson and Jungner criteria
Authors: E Leshem
Journal: Eurosurveillance (2012)

Preview this article: Letter to the editor: Screening for Coxiella burnetii infection during pregnancy: pros and cons according to the Wilson and Jungner criteria, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/7/art20090-en-1.gif
The grieving spouse
Authors: M Greenblatt
Journal: American Journal of Psychiatry (1978)

Loss of a spouse presents serious risks to the psychological and physical health and well-being of the survivor. This is particularly true for women. Physical disease, hospitalization, and mortality in widows all exceed expected rates. The author reviews the phases of mourning, the factors related to pathological grief, and the ways in which grief is resolved. He describes widow-to-widow care systems, which seem to have substantial merit. Pastoral counseling and in some cases psychiatric care and medication can be helpful, but time is the greatest healer of all.
Comparison Of Flow Cytometric and Clinical Findings In Patients With Paroxysmal Nocturnal Hemoglobinuria
Authors: Taner Demirer, Suphi Baslar, Vasif akin Uysal, Meral Beksac, Mehmet Ozen, Nahide Konuk, Osman Ilhan, Onder Arslan, Muhit Ozcan, Pervin Topcuoglu, Gunhan Gurman
Journal: Blood (2013)
Abstract P5-03-12: Selenocystine inhibits triple-negative breast cancer cell proliferation by inducing cell apoptosis and S-phase arrest
Authors: M Long, W Qiu, J Wu, R Liu, H Su
Journal: Cancer Research (2016)

Abstract Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited effective treatment options. New therapeutic approaches are urgently needed to improve the prognosis of TNBC. Reactive oxygen species (ROS) are inherent byproducts of oxidative metabolism, and forced stimulation of glucose oxidation in cancer cells raises oxidative stress and sensitizes cells to different stresses. Therefore, targeting the antioxidant capacity of cancer cells has become a promising anticancer strategy. As a redox modulator, selenocystine (SeC) has received a great deal of attention and has been shown effective against human melanoma, hormone receptor-positive breast cancer, and cancers of liver, lung and cervical in vitro. However, whether SeC exerts an anticancer effect on TNBC cells has never been explored. Methods: The dose-response effects and time course of effects of SeC on three different TNBC cell lines, MDA-MB-231, MDA-MB-436 and MDA-MB-468, were investigated in this study. Cellular viability was determined by the CCK-8 assay and cell morphology were recorded under a light microscope. Cellular apoptosis was detected using Annexin V/PI staining assay and cell cycle distribution was analyzed by flow cytometry. Results: SeC induced cell growth inhibition in all three TNBC cell lines. For 24, 48 and 72 hours of SeC treatments, the IC50 values were 40.8, 12.8 and 9.2 μM for MDA-MB-231 cells; 14.6, 5.4 and 3.0 μM for MDA-MB-436 cells; and 69.6, 29.3 and 19.9 μM for MDA-MB-468 cells. The changes of cellular morphology of TNBC cells in response to SeC treatment were similar to those cells undergoing apoptotic pathway. This result was confirmed by Annexin V/PI staining assays (Table 1). Cell cycle analysis further revealed that SeC also induced S-phase arrest in a dose-dependent manner (Table 2). Conclusion: In summary, SeC inhibited TNBC cell viability in a dose- and time-dependent manner which was attributed to the induction of apoptosis and S-phase arrest. Our finding indicates that SeC is a potential therapeutic agent for TNBC. Table 1. Apoptotic rate of TNBC cells after SeC treatment.Conc.(μM)MDA-MB-231MDA-MB-436MDA-MB-46805.8 %18.1 %26.7 %1025.5 %45.8 %60.7 %2040.1 %67.1 %70.9 %4054.7 %70.7 %74.5 % Table 2. SeC induces S-phase arrest in TNBC cells in a dose-dependent manner. Conc.(μM)G0/G1 (%)S (%)G2/M (%)MDA-MB-231016.655.927.5 1050.139.310.6 2045.548.16.4 4041.753.05.3MDA-MB-436042.127.630.3 1036.335.028.7 2034.340.725.0 4032.445.422.2MDA-MB-468059.123.717.2 1054.929.315.8 2050.135.714.2 4043.843.113.1 Citation Format: Long M, Qiu W, Wu J, Liu R, Su H. Selenocystine inhibits triple-negative breast cancer cell proliferation by inducing cell apoptosis and S-phase arrest. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-03-12.