tbuckley/cabot-search huggingface dataset:
Low-Dose Decitabine Vs Best Supportive Care In Older Patients With AML and Low Blast Counts: Results Of a Subgroup Analysis Of The Randomized Phase III Study 06011 Of The EORTC Leukemia Cooperative Group and German MDS Study Group
Authors: Heiko Becker, Stefan Suciu, Björn Rüter, Uwe Platzbecker, Aristoteles Giagounidis, Dominik Selleslag, Boris Labar, Ulrich Germing, Helmut R. Salih, Petra Muus, Karl-Heinz Pflüger, Anne Hagemeijer, Hans-Eckart Schaefer, Frédéric Baron, Arnold Ganser, Carlo Aul, Theo de Witte, Pierre W. Wijermans, Michael Lübbert
Journal: Blood (2013)
Abstract 14124: MyD88 - A Key Factor in the Anti-Apoptotic Role of IL-10 in Cardiomyocytes
Authors: Ashim K Bagchi, Anita K Sharma, Sanjiv Dhingra, Ana Ludke, Abd Al-Rahman Al-Shudiefat, Pawan K Singal
Journal: Circulation (2011)

Heart failure subsequent to a variety of etiologies is generally associated with an increase in pro-inflammatory cytokine, tumor necrosis factor-α (TNF-α), which is also known to cause apoptosis. I...
Multimodal MRI features predict isocitrate dehydrogenase genotype in high-grade gliomas
Authors: Biqi Zhang, Ken Chang, Shakti Ramkissoon, Shyam Tanguturi, Wenya Linda Bi, David A. Reardon, Keith L. Ligon, Brian M. Alexander, Patrick Y. Wen, Raymond Y. Huang
Journal: Neuro-Oncology (2016)

Abstract Background. High-grade gliomas with mutations in the isocitrate dehydrogenase (IDH) gene family confer longer overall survival relative to their IDH-wild-type counterparts. Accurate determination of the IDH genotype preoperatively may have both prognostic and diagnostic value. The current study used a machine-learning algorithm to generate a model predictive of IDH genotype in high-grade gliomas based on clinical variables and multimodal features extracted from conventional MRI. Methods. Preoperative MRIs were obtained for 120 patients with primary grades III (n = 35) and IV (n = 85) glioma in this retrospective study. IDH genotype was confirmed for grade III (32/35, 91%) and IV (22/85, 26%) tumors by immunohistochemistry, spectrometry-based mutation genotyping (OncoMap), or multiplex exome sequencing (OncoPanel). IDH1 and IDH2 mutations were mutually exclusive, and all mutated tumors were collapsed into one IDH-mutated cohort. Cases were randomly assigned to either the training (n = 90) or validation cohort (n = 30). A total of 2970 imaging features were extracted from pre- and postcontrast T1-weighted, T2-weighted, and apparent diffusion coefficient map. Using a random forest algorithm, nonredundant features were integrated with clinical data to generate a model predictive of IDH genotype. Results. Our model achieved accuracies of 86% (area under the curve [AUC] = 0.8830) in the training cohort and 89% (AUC = 0.9231) in the validation cohort. Features with the highest predictive value included patient age as well as parametric intensity, texture, and shape features. Conclusion. Using a machine-learning algorithm, we achieved accurate prediction of IDH genotype in high-grade gliomas with preoperative clinical and MRI features.
Updates in the management of brain metastases
Authors: Nils D Arvold, Eudocia Q Lee, Minesh P Mehta, Kim Margolin, Brian M Alexander, Nancy U Lin, Carey K Anders, Riccardo Soffietti, D Ross Camidge, Michael A Vogelbaum, Ian F Dunn, Patrick Y Wen
Journal: Neuro-Oncology (2016)

The clinical management/understanding of brain metastases (BM) has changed substantially in the last 5 years, with key advances and clinical trials highlighted in this review. Several of these changes stem from improvements in systemic therapy, which have led to better systemic control and longer overall patient survival, associated with increased time at risk for developing BM. Development of systemic therapies capable of preventing BM and controlling both intracranial and extracranial disease once BM are diagnosed is paramount. The increase in use of stereotactic radiosurgery alone for many patients with multiple BM is an outgrowth of the desire to employ treatments focused on local control while minimizing cognitive effects associated with whole brain radiotherapy. Complications from BM and their treatment must be considered in comprehensive patient management, especially with greater awareness that the majority of patients do not die from their BM. Being aware of significant heterogeneity in prognosis and therapeutic options for patients with BM is crucial for appropriate management, with greater attention to developing individual patient treatment plans based on predicted outcomes; in this context, recent prognostic models of survival have been extensively revised to incorporate molecular markers unique to different primary cancers.
Case 17-1969
Authors: Daniel D. Federman, Richard B. Cohen
Journal: New England Journal of Medicine (1969)

Presentation of CaseA sixty-seven-year-old man was admitted to the hospital because of edema of the legs.One year previously he was admitted to another hospital after a seizure; pneumonia developed, with a slow recovery. Nine months before admission ankle edema occurred, and digitalis and chlorthalidone (Hygroton) were begun and continued to the time of entry. Because of weakness of the legs he remained in bed and chair in a nursing home during the next six months. Three months before entry the edema of the legs subsided, and he returned home, where he was ambulatory and able to care for . . .
Regulating Abortion Services
Authors: V P Riggs
Journal: New England Journal of Medicine (1980)

It is ironic that the informed-consent provisions regarding abortion of the Akron legislation indirectly require doctors to lie to their patients regarding the risks involved in abortion. Also, the idea that a description of the fetus is not relevant to a woman's decision to abort is to deny the possible existence of a second human being. If the existence of a second being is established, then describing fetal characteristics should not prejudice a woman's decision to continue the pregnancy, nor should it produce guilt feelings over the decision to abort the pregnancy. If however, description of fetal characteristics questions the presence of a second being, then this information is important to the woman's decision. Describing the fetus as fetal tissue or products of conception and conveying an image of a blood clot or placental fragment is an understatement. As women do not take lightly the decision to abort their pregnancies, they have the right to be informed of what is being removed before they make the decision. Ethical considerations are involved in the abortion issue, and women contemplating abortion should not be deprived of the description of the fetus, whether or not she requests it, if they are to give truly informed consent.
The Electron Microscopy of Tobacco Smoke
Authors: H. Kahler, Bolivar J. Lloyd, Jr.
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article The Electron Microscopy of Tobacco Smoke Get access H. Kahler, H. Kahler National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Bolivar J. Lloyd, Jr. Bolivar J. Lloyd, Jr. National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 2, February 1957, Pages 217–229, https://doi.org/10.1093/jnci/18.2.217 Published: 01 February 1957 Article history Received: 20 June 1956 Published: 01 February 1957
P-251 Prone-position thoracoscopic esophagectomy (bilateral pulmonary ventilation) for esophageal cancer with respiratory dysfunction
Authors: T. Michiura, K. Inoue, M. Hamada, H. Miki, R. Inada, M. Oishi, T. Ozaki, H. Mukaide, M. Kon
Journal: Annals of Oncology (2016)
Organic Transistor Arrays Integrated with Finger‐Powered Microfluidics for Multianalyte Saliva Testing
Authors: Anna‐Maria Pappa, Vincenzo F. Curto, Marcel Braendlein, Xenofon Strakosas, Mary J. Donahue, Michel Fiocchi, George G. Malliaras, Roisin M. Owens
Journal: Advanced Healthcare Materials (2016)

A compact multianalyte biosensing platform is reported, composed of an organic electrochemical transistor (OECT) microarray integrated with a pumpless “finger‐powered” microfluidic, for quantitative screening of glucose, lactate, and cholesterol levels. A biofunctionalization method is designed, which provides selectivity towards specific metabolites as well as minimization of any background interference. In addition, a simple method is developed to facilitate multi‐analyte sensing and avoid electrical crosstalk between the different transistors by electrically isolating the individual devices. The resulting biosensing platform, verified using human samples, offers the possibility to be used in easy‐to‐obtain biofluids with low abundance metabolites, such as saliva. Based on our proposed method, other types of enzymatic biosensors can be integrated into the array to achieve multiplexed, noninvasive, personalized point‐of‐care diagnostics.
Case 17-1984
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, A. A. Sasahara, E. J. Mark
Journal: New England Journal of Medicine (1984)

Presentation of CaseA 74-year-old man was admitted to the hospital because of dyspnea and bilateral pulmonary infiltrates.He was well until 25 months earlier, when he was seen at another hospital because of painful knees. Laboratory studies showed hyperglobulinemia; serum immunoelectrophoresis revealed an IgG kappa M component, and microscopical examination of an aspirated specimen of bone marrow disclosed 50 per cent plasma cells. Melphalan and prednisone were administered for nine months and then discontinued. The patient felt well without further treatment until three months before admission, when he began to experience increasing pain in the back and ribs. Constipation, . . .
C-reactive protein (CRP) and peripheral blood monocyte count (PBMC) in patients (pts) with advanced soft tissue sarcomas (ASTS) treated with trabectedin (TR): correlation with progression-free survival (PFS).
Authors: Danilo Galizia, Paola Boccone, Sara Miano, Erica Palesandro, Lorenzo D'Ambrosio, Francesco Tolomeo, Sandra Aliberti, Ilaria Bertotto, Marco Gatti, Antonio Manca, Massimo Aglietta, Giovanni Grignani
Journal: Journal of Clinical Oncology (2015)

e21517 Background: Several evidences showed systemic inflammation is directly implicated in cancer development and progression. Accordingly, a relationship between inflammatory features (CRP, neutrophil and lymphocyte ratio) and prognosis was demonstrated in localized STS. On the contrary, no data are available in ASTS treated with chemotherapy. TR, a peculiar anti-neoplastic drug, causes both specific DNA damage and anti-inflammatory activity on the tumor microenvironment reducing several cytokines (eg: IL-6) and tumor-infiltrating monocytes/macrophages (D’Incalci BJC 2014). We assessed if inflammatory status (measured by CRP) and PBMC reduction induced by TR correlated with outcome. Methods: In our prospectively collected database, we identified pts affected by ASTS and treated with TR 1.5 mg/m2 as a 24-h infusion/3wks and for whom CRP and PBMC were available. We evaluated the correlation of these inflammatory parameters with progression. Receiver operating characteristic (ROC) curve analysis was applied to identify the best discriminating cutoff value for CRP and the PBMC ratio evaluated between baseline and first nadir count. Chi-square test with odds ratio and log-rank test were used to compare outcomes. Kaplan and Meier method was used to estimate PFS. Results: 69 patients, mean age 59 yrs, affected by LPS, LMS and UPS with a median follow up of 9.3 months were analyzed. Median baseline CRP and PBMC were 0.08 (NV < .005 g/L) and 610/uL (NV: 160-1000), respectively. Normal CRP predicted better PFS (p = .006) and 6-month PFS probability (OR: 29.2 p = .026). After TR therapy PMBC was significantly reduced from 724/uL to 497/uL at nadir (p < .001). A PBMC reduction ≥ 30% was correlated with a higher probability of being progression-free at first evaluation (OR: 3.7 IC: 1.3-10.2: p = .002). PBMC reduction ≥ 30% was correlated with an improved PFS in high-CRP pts (OR: 3.3 p = .04) too. Conclusions: In ASTS treated with TR, elevated CRP recognizes pts with a worse prognosis, whereas a ≥ 30% reduction PBMC at nadir might be used to identify patients benefitting from TR. These data need to be validated in a different series.
Low-dose gemcitabine and radiation alternated to cisplatin/5fu in stage IV squamous cell carcinoma of the head and neck (HN- SCC): A phase II trial
Authors: M. Benasso, V. Vigo, A. Bacigalupo, A. Ponzanelli, M. Marcenaro
Journal: Journal of Clinical Oncology (2007)

6062 Background: At the National Institute for Cancer Research of Genoa, Italy, we conducted two consecutive phase II single-institution trials testing the addition of gemcitabine into an alternating chemo-radiation (CT/RT) regimen that is considered standard of care in our Institute for patients (pts) with loco-regional advanced HN-SCC (NEJM, 327:1115,1992). In the former trial (ALT-G trial; 47 pts) high dose gemcitabine was administered with cisplatin and RT (Annals of Oncology, 15:646,2004). Methods: In the present trial (ALT-g trial) 3 courses of cisplatin, 20 mg/m 2 /day and 5-fluorouracil, 200 mg/m 2 /day, days 1–5 (weeks 1, 4, 7) alternated to 3 courses of standard RT (weeks 2–3, 5–6, 8–9) up to 60 Gy and gemcitabine, 40 mg/m2 on monday of each week of RT, were administered to 47 pts with stage IV (42 pts) or relapsed after surgery (5 pts), unresectable SCC of the oral cavity (11 pts), oropharynx (11 pts) hypopharynx-larynx (24 pts). None had previously received CT or RT. Results: Seven pts (15%) did not complete the planned treatment. Four of them died due to pulmonary embolism (2 pts), fulminant pneumonia (1 pt) or uncertain causes (1 pt). Main grade 3–4 other than local toxicities were: neutropenia (11%), neutropenia with fever (6%), thrombocytopenia (30%), anemia (17% grade 3). 27 pts reached a CR (57%). 7 PRs were rendered disease-free by surgery mainly on the neck (final CR rate: 72%). At a median follow-up of 37 months, 3-yr results and acute local toxicity are compared with those from ALT-G trial and from our data-base of pts treated with alternating cisplatin/5-FU and RT without gemcitabine (ALT): Conclusions: In conclusion, the addition of low-dose gemcitabine into a consolidated cisplatin/5FU and RT alternating program may improve the outcomes with an acceptable increase in acute severe mucositis. No significant financial relationships to disclose. [Table: see text]
Case 46-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, David M. Witten, Austin L. Vickery
Journal: New England Journal of Medicine (1976)

Presentation of CaseAn 84-year-old man was admitted to the hospital because of impaired renal function.A myocardial infarction had occurred 15 years earlier. Four months before entry the left leg was amputated above the knee because of pain in the foot at rest and an angiographic finding of occlusion of the left common iliac artery at the aortic bifurcation; the superficial femoral artery was patent, but the proximal portion of the popliteal artery was also occluded. A postoperative urinary-tract infection was treated with cephalexin, and the patient was transferred to a rehabilitation facility.He participated actively in physical therapy . . .
Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis
Authors: P F Renshaw, D A Yurgelun-Todd, M Tohen, S Gruber, B M Cohen
Journal: American Journal of Psychiatry (1995)

The authors measured the ratio of N-acetyl aspartate (a putative neuronal marker) to creatine-phosphocreatine in patients with first-episode psychosis by using proton magnetic resonance spectroscopy (MRS).Temporal lobe 1H MRS was performed bilaterally on 13 patients with first-episode psychosis and 15 comparison subjects. The N-acetyl aspartate/creatine-phosphocreatine and choline/creatine-phosphocreatine ratios were determined.The N-acetyl aspartate/creatine-phosphocreatine ratio of the psychotic patients was significantly lower than that of the comparison subjects.These preliminary data suggest that abnormalities in temporal lobe N-acetyl aspartate concentration are present early in psychotic illness.
Virus-like Particles in Hyperplastic Alveolar Nodules of the Mammary Gland of the C3H/He CRGL Mouse&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Dorothy R. Pitelka, Howard A. Bern, Kenneth B. DeOme, Caroline N. Schooley, S. Robert Wellings
Journal: JNCI Journal of the National Cancer Institute (1958)

Virus-like Particles in Hyperplastic Alveolar Nodules of the Mammary Gland of the C3H/He CRGL Mouse Dorothy R. Pitelka, Dorothy R. Pitelka Department of Zoology and its Cancer Research Genetics Laboratory, University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Howard A. Bern, Howard A. Bern Department of Zoology and its Cancer Research Genetics Laboratory, University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Kenneth B. DeOme, Kenneth B. DeOme Department of Zoology and its Cancer Research Genetics Laboratory, University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Caroline N. Schooley, Caroline N. Schooley Department of Zoology and its Cancer Research Genetics Laboratory, University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Robert Wellings S. Robert Wellings Department of Zoology and its Cancer Research Genetics Laboratory, University of California, Berkeley, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 3, March 1958, Pages 541–553, https://doi.org/10.1093/jnci/20.3.541 Published: 01 March 1958 Article history Received: 23 August 1957 Published: 01 March 1958
Clonotypic Analysis Of Immunoglobulin Heavy Chain (IgH) Sequences In Patients With Waldenström’s Macroglobulinemia. Correlation With MYD88 L265P Somatic Mutation Status, Clinical Features and Outcome
Authors: Loizos Petrikkos, Marie-Christine Kyrtsonis, Maria Roumelioti, Anna Efthymiou, Tatiana Tzenou, George Georgiou, Dimitrios Maltezas, Panayiotis Panayiotidis
Journal: Blood (2013)
Chromosomal Evolution in B-Cell Chronic Lymphocytic Leukemia (B-CLL).
Authors: Paolo Bernasconi, Ilaria Giardini, Ester Orlandi, Marina Boni, Paola Maria Cavigliano, Silvia Calatroni, Barbara Rocca, Rita Zappatore, Irene Dambruoso, Marilena Caresana, Mario Lazzarino
Journal: Blood (2006)
Case 43-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, James M. Richter, Edward J. Gutmann
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 61-year-old man was admitted to the hospital because of abdominal pain and a mass in the right side of the abdomen.He was well until six weeks earlier, when crampy pain developed in the lower portion of the abdomen and frequently radiated throughout the entire abdomen. The pain occurred as often as eight times daily, without relation to meals, and lasted for two or three minutes each time. A barium-enema examination (Fig. 1) was negative except that the cecum was oriented horizontally; an upper gastrointestinal series showed no abnormality. During the week before admission the episodes . . .
Beginning careers in academic psychiatry for women--"Bermuda Triangle"?
Authors: L W Reiser, W H Sledge, W Fenton, P Leaf
Journal: American Journal of Psychiatry (1993)

The proportion of women in leadership positions in academic psychiatry has not kept pace with the increase in the number of women entering the field. This study examines differences in career activities between women and men who graduated from the Yale University psychiatric residency training program and explores whether these differences can be explained by preresidency expectations, residency experiences, or training immediately after residency.Departmental educational records of the Yale residency program were reviewed to determine professional interests expressed before psychiatric residency and training focus during residency for 355 residents in the 1970-1983 graduating classes. A 1984 follow-up study focused on their postresidency career activities. Differences in preresidency interests and experiences, training activities, and career paths between all female and male graduates and between women and men who chose academic careers were examined.After residency, the female graduates' marital status differed from men's--more had never married or were divorced. Women's professional activities diverged from men's; their practice pattern was different, they spent more hours teaching, and they had fewer publications in peer-reviewed journals. This divergence was not accounted for by differences in pretraining interests or in training focus during residency. The authors present possible explanations.Further research is indicated to determine the underlying causes of career differences between women and men in psychiatric practice and academia so that effective strategies for correcting the present inequality of women in senior faculty positions can be implemented.
P100 Improving paediatrics’ pressurised metered dose inhaler technique and asthma control: Inhaler verbal counselling vs. Trainhaler: Abstract P100 Table 1
Authors: WG Ammari, NK Al-Hyari, N Obeidat, M Khater, A Sabouba, M Sanders
Journal: Thorax (2015)

<h3>Introduction</h3> Verbal counselling (VC) is commonly used to train patients on correct inhaler technique. Patients forget the good inhaler use with time. Trainhaler (TH), Clement Clarke, UK, is a novel pressurised metered dose inhaler (MDI) training tool designed with feedback mechanisms to train patients coordinate releasing the aerosol with using a slow and deep inhalation flow (IF) through their MDI. Our aim was to compare VC with TH in children with asthma. <h3>Methods</h3> Ethical approval was obtained and all children and their parents gave signed consent. At visit 1, asthmatic children, age 7–17 years, with an MDI hand-lung coordination problem including an IF &gt;60 l/min were randomised into either the VC group that received verbal MDI training with emphasis on using a slow and deep IF; or into the TH group that were trained on- and given TH to practice at home. Children with correct MDI technique and IF ≤60 l/min formed the control group (CT). An 11-step MDI technique, peak IF through the inhaler and Asthma Control Questionnaire (ACQ) were evaluated. All subjects returned after 6 to 8 weeks (visit 2) for re-evaluation. <h3>Results</h3> Thirty children took part. Table 1 presents the study outcomes. All VC and TH had correct MDI steps and slow IF post-training at visit 1. Unlike CT, Wilcoxon test showed a significant decrease (p &lt; 0.01) in the incorrect MDI steps between visits 1 and 2, within VC and TH. Mann-Whitney test showed a significant difference (p &lt; 0.01) in the incorrect MDI steps between the CT and both intervention groups at visit 1, but no significant difference (p &gt; 0.05) was found at visit 2. Paired t-test showed significant reductions (p &lt; 0.01) in IF and ACQ within TH. In VC, the ACQ improved at visit 2, but the IF did not. <h3>Conclusion</h3> VC and TH improved the children’s MDI technique which was reflected on better asthma control. VC children could not, however, maintain the acceptable IF through their MDI which is critical for aerosol lung deposition. An inhaler training tool available to patients at any time can be helpful.