tbuckley/cabot-search huggingface dataset:
Adrenocortical Dysfunction: Reappraisal after 4 Years' Therapy
Authors: G D MOLNAR, V R MATTOX, F T MAHER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prophylactic Antibiotics May Do More Harm Than Good
Authors: S A GLADSTONE
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
EPT-20CLINICAL TARGETED EXOME-BASED SEQUENCING IN COMBINATION WITH GENOME WIDE COPY NUMBER PROFILING: A CLIA CERTIFIED APPROACH FOR PRECISION MEDICINE IN 203 PEDIATRIC BRAIN TUMOR PATIENTS
Authors: Pratiti Bandopadhayay, Shakti Ramkissoon, Jaeho Hwang, Lori Ramkissoon, Adrian Dubuc, Steven Schumacher, Katherine Janeway, Nathan Pinches, Hayley Malkin, Claire Sinai, Peter Manley, Karen Wright, Mariella Filbin, Liliana Goumnerova, Sanda Alexandrescu, Marian Harris, Azra Ligon, Mark Kieran, Susan Chi, Rameen Beroukhim, Keith Ligon
Journal: Neuro-Oncology (2016)
Insulin-Pump Therapy for Type 1 Diabetes Mellitus
Authors: Ian Blumer, Steven V Edelman, Irl B Hirsch
Journal: New England Journal of Medicine (2012)

n engl j med 367;4 nejm.org july 26, 2012 383 the Premier HQID died within 30 days of hospitalization, with some hospitals achieving mortality rates that were half that of others.1 This finding suggests that there remains plenty of opportunity for improvement. Neither our study nor others have evaluated whether the HQID had an effect on the broader U.S. health care environment. Although the failure of the HQID to improve outcomes suggests that we have not yet learned the best way to structure payfor-performance programs, it says nothing critical about the hospitals that were willing to try this novel payment method or about the agency that was bold enough to try this approach. Ultimately, the Premier HQID was an important experiment that has taught us a tremendous amount about the effects of incentives on health care. Ashish K. Jha, M.D., M.P.H. Karen E. Joynt, M.D., M.P.H. Arnold M. Epstein, M.D.
ABC of smoking cessation: Nicotine replacement therapy
Authors: A Molyneux, E Králíková, V Himmerová
Journal: BMJ (2004)

Nicotine replacement therapy doubles the success rate in smoking cessation during all intervention levels - so its effectiveness is higher with the most intensive support. The patient can choose the NRT form since the effectiveness does not differ substantially. Nicotine replacement therapy should be offered to each nicotine dependent smoker willing to stop. In the case of abstinence the treatment should be taken at least 6 to 8 weeks.
PCM-21EXPRESSION OF IMMUNE CHECKPOINT PROTEINS IN PATIENT-DERIVED PEDIATRIC BRAIN TUMOR XENOGRAFTS
Authors: Eric Ring, Blake Moore, Li Nan, Tina Etminan, James Markert, G. Yancey Gillespie, Gregory Friedman
Journal: Neuro-Oncology (2016)

PCM-21. EXPRESSION OF IMMUNE CHECKPOINT PROTEINS IN PATIENT-DERIVED PEDIATRIC BRAIN TUMOR XENOGRAFTS Eric Ring, Blake Moore, Li Nan, Tina Etminan, James Markert, G. Yancey Gillespie, and Gregory Friedman; University of Alabama at Birmingham, Birmingham, AL, USA Pediatric brain tumors represent the most common solid tumor in children and the leading cause of cancer morbidity and mortality. Standard of care includes surgery, chemotherapy and radiation, which are all very damaging to a developing child. While these therapies have improved survival rates, outcomes remain extremely poor for patients with refractory disease. To improve outcomes and lessen toxicities, novel, directed therapies are needed. Recently, immunosuppressive checkpoint molecules that negatively regulate immune cell function and enable local tumor escape, such as PD-L1, CTLA-4, CD200andIndolamine2,3-dioxygenase (IDO),havebeendescribed inadultbrain tumors.Agentsdesigned to inhibit theseproteinshave shownsignificant efficacy in human adult solid tumor studies. Little is known about expression of these checkpoint molecules in pediatric brain tumors. After disaggregation of six patient derived xenografts (2 glioblastoma (GBM), 2 medulloblastoma (MB), and 2 supratentorial primitive neuroendocrine tumors (SPNETs)) harvested from athymic nude mice, we performed flow cytometry to quantify expression of CTLA-4, PD-L1, CD200, and IDO. All three tumor types had high expression levels of IDO (range 60.3-98.7%) and low expression of CD200 (0.5-14.4%). MB and SPNETs expressed low levels of CTLA-4 (2.2-7.5% and 4.2-11.6%, respectively) while GBM showed variable expression (20.5-38.3%). PD-L1 was highly expressed in MB (90.2-91.9%) and variably expressed in SPNETs and GBM (13.2-63.8% and 13.2-87.8%, respectively). Our results suggest that pediatric brain tumors express targetable immune checkpoint molecules, with expression of IDO consistently high, PD-L1 variable, and CD200 and CTLA-4 low. Neuro-Oncology 18:iii139–iii144, 2016. doi:10.1093/neuonc/now080.21 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
The P2X4 purinergic receptor impacts liver regeneration after partial hepatectomy in mice through the regulation of biliary homeostasis
Authors: Aurore Besnard, Julien Gautherot, Boris Julien, Ali Tebbi, Isabelle Garcin, Isabelle Doignon, Noémie Péan, Emmanuel Gonzales, Doris Cassio, Brigitte Grosse, Bingkaï Liu, Hanaa Safya, Florent Cauchois, Lydie Humbert, Dominique Rainteau, Thierry Tordjmann
Journal: Hepatology (2016)

Many regulatory pathways are involved in liver regeneration after partial hepatectomy (PH), to initiate growth, protect liver cells, and sustain remnant liver functions. Extracellular adenosine triphosphate rises in blood and bile after PH and contributes to liver regeneration, although purinergic receptors and mechanisms remain to be precisely explored. In this work we analyzed during regeneration after PH the involvement of P2X4 purinergic receptors, highly expressed in the liver. P2X4 receptor expression in the liver, liver histology, hepatocyte proliferation, plasma bile acid concentration, bile flow and composition, and lysosome distribution in hepatocytes were studied in wild‐type and P2X4 knockout (KO) mice, before and after PH. P2X4 receptors were expressed in hepatocytes and Kupffer cells; in hepatocytes, P2X4 was concentrated in subcanalicular areas closely costained with lysosomal markers. After PH, delayed regeneration, hepatocyte necrosis, and cholestasis were observed in P2X4‐KO mice. In P2X4‐KO mice, post‐PH biliary adaptation was impaired with a smaller increase in bile flow and HCO 3 − biliary output, as well as altered biliary composition with reduced adenosine triphosphate and lysosomal enzyme release. In line with these data, lysosome distribution and biogenesis were altered in P2X4‐KO compared with wild‐type mice. Conclusion: During liver regeneration after PH, P2X4 contributes to the complex control of biliary homeostasis through mechanisms involving pericanalicular lysosomes, with a resulting impact on hepatocyte protection and proliferation. (H epatology 2016;64:941‐953)
Effects of Cell Density on Cell Growth in a Clone of Mouse Liver Cells<xref ref-type="fn" rid="FN1">2</xref>
Authors: Donald M. Pace, Lefkos Aftonomos
Journal: JNCI Journal of the National Cancer Institute (1957)

Effects of Cell Density on Cell Growth in a Clone of Mouse Liver Cells Get access Donald M. Pace, Donald M. Pace Institute for Cellular Research, Department of Physiology, University of Nebraska, Lincoln, Nebraska Search for other works by this author on: Oxford Academic PubMed Google Scholar Lefkos Aftonomos Lefkos Aftonomos Institute for Cellular Research, Department of Physiology, University of Nebraska, Lincoln, Nebraska Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 6, December 1957, Pages 1065–1075, https://doi.org/10.1093/jnci/19.6.1065 Published: 01 December 1957 Article history Received: 17 June 1957 Published: 01 December 1957
Reduction of interobserver variability (IOV) by FDG-PET–based tumor volume delineation (TVD) in radiotherapy planning for pancreatic cancer.
Authors: Jennifer Mary Rose Branagan, Charlotte Halle, Stephen Falk, Ganesh Radhakrishna, Rajarshi Roy, Thomas Crosby, Chris Hurt, Thomas B. Brunner, Somnath Mukherjee
Journal: Journal of Clinical Oncology (2013)

229 Background: Wide IOV has been reported for CT-based TVD during radiotherapy planning for pancreatic cancer (Yamazaki, Anticancer Research 27: 2965-2972, 2007). PET-CT has been successfully incorporated into treatment planning in other tumour sites and has been shown to reduce IOV, but no study has looked at its role in pancreatic radiotherapy. Methods: Six radiation oncologists from 6 oncology centers in the UK were asked to outline GTVs in two cases with pancreatic head tumors. DICOM data set of planning CT, diagnostic CT and FDG-PET-CT scans were made available. GTV was first outlined using the information on the diagnostic CT scan alone, without access to PET scans (GTV_CT). The GTVs were then re-outlined using additional information from the PET scan (GTV_PET). A PTV was grown from the GTV, using a margin of 2cm sup-inf and 1.5cm radially from the GTV, as per standard UK practice. Results: A total of 48 countours (24 GTV contours and 24 PTV contours) were analysed, and the results are presented below (Table). Conclusions: The incorporation of PET scan resulted in a prominent reduction in standard deviation around tumor volumes, smaller largest:smallest GTV ratios and a larger percentage of overlap between investigator volumes, suggesting a reduction in Inter-Observer Variability. PET based RT planning should be considered in multicenter radiotherapy trials in pancreatic cancer to reduce IOV. [Table: see text]
New Key Words and Index
Authors: E.J. H.
Journal: Annals of Internal Medicine (1970)

Editorial Notes1 December 1970New Key Words and IndexE.J. H.E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-73-6-1040 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptAlert readers of the Annals may have noticed that the key words on the abstracts in the Medical News section have been appearing in a new format, with a different vocabulary, since July of this year. Previously the key words had been those supplied by the authors of the abstracted papers, with some terms added or modified by the editors. Beginning with the July issue, the key words have been drawn from the vocabulary developed by the National Library of Medicine for compilation ofIndex Medicus. This vocabulary is titledMedical Subject Headings, and its terms are known acronymically as... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1970Volume 73, Issue 6Page: 1040-1041KeywordsLibraries ePublished: 1 December 2008 Issue Published: 1 December 1970 PDF downloadLoading ...
Targeted Strategies in the Treatment of Metastatic Colon Cancer
Authors: Diane Reidy, Leonard Saltz
Journal: Journal of the National Comprehensive Cancer Network (2007)

Advances in the understanding of tumor biology have led to the identification of important cellular processes involved in the pathogenesis of colon cancer. Drugs that interfere with these critical pathways are known as targeted agents . The goal of these therapies is to selectively interrupt the signal transduction pathways responsible for tumor growth and survival. Some of these targeted agents have made important, albeit modest, contributions to the treatment of patients with metastatic colorectal cancer. However, the activity levels with the currently available targeted therapies are far lower than experts had hoped, and toxicities are often nontrivial. This article reviews the available therapies, the data that justify their use, and the challenges of optimizing targeted therapies through combinations with cytotoxic chemotherapies and other targeted agents. Finally, some newer drugs and strategies currently being tested in clinical trials are discussed.
Metronomic capecitabine and bevacizumab is an active combination in patients with relapsed peritoneal pseudomyxoma
Authors: M. Niger, C. Maggi, M. Di Bartolomeo, F. Perrone, E. Tamborini, M. Milione, M. Deraco, S. Kusamura, D. Baratti, R. Berenato, M. Caporale, P.V. Consonni, I. Bossi, E. Leo, G. Pelosi, F. de Braud, F. Pietrantonio
Journal: Annals of Oncology (2015)
Military Medicine
Authors: Daniel S. Greenberg
Journal: New England Journal of Medicine (1979)

"During our military hospital visits, we interviewed 47 physicians and hospital administrative officials to find out why physicians were leaving the military, what practices they resent, and what conditions create inefficiencies and waste their time."The "we" refers to investigators from the General Accounting Office, which works for the U.S. Congress, and what they found is contained in a newly issued report that is appropriately titled like a telegraphed appeal for help: Military Medicine Is in Trouble: Complete reassessment needed. Whether still more reassessments are needed for the much-assessed persistency of medical staffing problems in the armed services seems . . .
Home Treatment of Tuberculosis
Authors: A H COUCH
Journal: New England Journal of Medicine (1938)

BEIAL JOURAL 1539scoliosis by a group, including an orthopaedic surgeon, an anatomist, a neurologist, a path- ologist, a radiologist, and perhaps an engineer with knowledge of the properties of materials and of stresses and strains.When the distorting forces causing scoliosis are further understood it will be much easier to determine their origin.The beginnings of such a study have already been started at the Brompton Hospital, and will soon be extended.I would welcome hearing from anyone interested in these wider aspects of this problem.-I am, etc.,
"PROFILE LINE" IN ROENTGENOLOGIC DIFFERENTIATION OF INTRINSIC AND EXTRINSIC LESIONS OF THE STOMACH
Authors: E L PIRKEY, E S REED, W H SMITH, G WHITEMAN
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
LG-74STRATEGIES FOR THE SURGICAL MANAGEMENT OF PEDIATRIC OPTIC PATHWAY GLIOMAS - EXPERIENCE WITH 100 PATIENTS
Authors: Eveline Teresa Hidalgo, Svetlana Kvint, Cheddhi Thomas, Cordelia Orrilac, Emily North, Yosef Dastagirzada, Matija Snuderl, Jeffrey H. Wisoff
Journal: Neuro-Oncology (2016)
Mastering change: epidemiological and case studies in Senegal, West Africa
Authors: M Beiser, H Collomb
Journal: American Journal of Psychiatry (1981)

While it has often been assumed that persons exposed to rapid social change incur a risk to their mental health, research results have been inconsistent. The authors found that 269 urban migrants in Senegal, West Africa, did not demonstrate worse mental health than did 300 rural nonmigrants. Case studies suggest that outcome is determined not by change per se but by social contingencies which modify the situations, as well as by personal assets which individuals bring with them. Critical factors include the persistence of familiar cultural forms within the new environment and skills such as literacy and the ability to creatively integrate elements of the old and new cultures.
Temporal disorganization and inner-outer confusion in acute mental illness
Authors: F T Melges, A M Freeman
Journal: American Journal of Psychiatry (1977)

The authors found that changes in temporal disorganization covaried substantially and significantly with changes in Schneider's first-rank symptoms in 58 acutely ill psychiatric patients. Schneiderian symptoms reflect a confusion of inner and outer events; therefore, the findings suggest that difficulties in indexing events in time are closely related to problems in distinguishing experiences that arise within the self from outer experiences.
RADIOSENSITIVITY OF TUMORS
Authors: S WARREN
Journal: JAMA (1934)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Bariatric surgery for obesity-associated decline in kidney function: filling the knowledge gap?
Authors: Varun Agrawal, Sankar D. Navaneethan
Journal: Kidney International (2016)

Chang et al. (2016) report a significantly lower risk of decline in estimated glomerular filtration rate among obese adults who underwent bariatric surgery compared with a matched nonsurgical cohort. In this propensity-matched analysis, data on confounding variables such as albuminuria, psychosocial, and medical conditions that precluded surgery in the comparator arm and health insurance are lacking. Furthermore, creatinine-based estimated glomerular filtration rate is not an accurate measure of kidney function after intentional weight loss. Although the study is interesting, physicians need to carefully weigh the risks versus benefits of bariatric surgery among obese adults at risk of kidney disease.
Inflammatory Pseudotumor of the Common Bile Duct
Authors: R.  Sobesky, J.  M.  Chollet, F.  Prat, B.  Karkouche, G.  Pelletier, J.  Fritsch, A.  D.  Choury, C.  Allonier, P.  Bedossa, C.  Buffet
Journal: Endoscopy (2003)

An exceptional cause of obstructive jaundice is reported in the present case. A 51-year-old woman progressively developed jaundice with pruritus, and abdominal ultrasonography revealed dilated intra- and extrahepatic bile ducts. Endoscopic retrograde cholangiography and endoscopic ultrasonography showed a tumor in the distal common bile duct, but failed to determine the nature of the lesion, and the patient underwent a pancreaticoduodenectomy. The final diagnosis was an inflammatory pseudotumor of the common bile duct. Inflammatory pseudotumors are uncommon, without evident pathogenesis, and are described in many organs. The localization in the common bile duct is exceptional. The prognosis is good, and a more conservative approach is possible if the diagnosis is certain before surgery.
Implantable cardioverter-defibrillator therapy in arrhythmogenic right ventricular cardiomyopathy**Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Thomas Wichter, Günter Breithardt
Journal: Journal of the American College of Cardiology (2005)
Two Views
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1979)

Richard Cabot of the Massachusetts General Hospital introduced the clinicopathological conference (CPC) as a formal teaching exercise early in this century, and it soon became an important feature of the educational programs at the MGH and at most other United States teaching hospitals. In 1926 we began to publish transcripts of these exercises as a weekly feature in the Journal, and we have continued without interruption for more than 50 years.Over the intervening decades, although the practice of medicine has undergone vast changes and diagnosis has become much less dependent on the autopsy, the CPC as a teaching . . .