tbuckley/cabot-search huggingface dataset:
Efficacité comparée de l'hépatico-gastrostomie guidée par échoendoscopie et du drainage percutané trans-hépatique pour obstruction biliaire d'origine tumorale après échec de drainage par CPRE
Authors: A Sportes, M Camus, S Leblanc, S Grabar, R Coriat, J Hochberger, S Chaussadel, F Prat
Journal: Endoscopy (2016)

La technique de référence pour le drainage palliatif des obstacles tumoraux de la voie biliaire principale est la Cholangio-Pancréatografie Rétrograde Endoscopique (CPRE). En cas d'échec de drainage rétrograde, un drainage per cutané par voie trans-hépatique est généralement proposé aux patients. Récemment la technique de drainage biliaire guidé par échoendoscopie a été développée permettant de réaliser une hépatico-gastrostomie à partir des voies biliaires gauches.
Molecular profiling of patient derived cells (PDCs) from metastatic cancer patients using CancerSCAN: Highly profiled models to test the efficacy of genome-directed therapy in cancer.
Authors: Seung Tae Kim, Jiryeon Jang, Sun Kim, Se Hoon Park, Joon Oh Park, Ho Yeong Lim, Young Suk Park, Keunchil Park, Woong Park, Kyoung Mee Kim, Tae Sohn, Won Ki Kang, Jeeyun Lee
Journal: Journal of Clinical Oncology (2015)

e22241 Background: Recent advances in translational research have been largely accompanied by improvement of tumor cell model. In this study, we established the patient-derived cell (PDC) models from metastatic cancer patients using various sources of tissues i.e. ascites, pleural fluid, endoscopic biopsies, surgical specimens. Methods: PDCs were established from metastatic gastric cancer, colon, hepatobiliary, and rare cancer patients who were enrolled on to the NEXT-1 trial (NCT#02141152) or Biomarker study (NCT#01831609). We prospectively established PDCS from metastatic cancer patients who enter the NEXT-1 trial, the master protocol for genome-directed matched treatment at Samsung Medical Center. For the NEXT-1 trial, the primary tumor specimens are all sequenced with CancerSCAN or Ion Torrent Ampliseq 2.0. For the Biomarker study, all unstained slides and any malignant ascites, pleural effusion were collected, cultured, and stored for later use. Results: In this study, we profiled gastric cancer and colon cancer PDCs, that were successfully established from tissue specimens or body fluids. In the first interim analysis, 130 PDCs were successfully established from 176 cases (submitted work). We demonstrated that PDCs retain major genomic alterations and histologic features of the primary tumor. Few of the chacterized PDCs harbored EML4-ALK translocation, NTRK1 translocation, HER2, EGFR amplifications and MET amplifications. We observed the correlation between drug response to NTRK inhibitor in NTRK1 translocated cancer cells, as well as MET inhibitor in MET amplified cancer cells. Conclusions: In this study, we report on the genomically profiled primary cell line bank that can be used for screening of molecularly targeted agents. We are currently testing an array of drug in these genome-widely profiled PDCs.
TCTAP A-015 Manual Thrombus Aspiration During Primary Percutaneous Coronary Intervention: Impact of Total Ischemic Time
Authors: Doo Sun Sim, Myung-Ho Jeong, Youngkeun Ahn, Young Jo Kim, Shung Chull Chae, Taek Jong Hong, In-Whan Seong, Jei Keon Chae, Chong-Jin Kim, Myeong-Chan Cho, Seung-Woon Rha, Jang-Ho Bae, Ki-Bae Seung, Seung-Jung Park
Journal: Journal of the American College of Cardiology (2016)
Hydroxyurea Therapy Reduces The Hypercoagulability State In a Sickle Cell Mouse Model
Authors: Marina Pereira Colella, Camila Bononi Almeida, Nicola Conran, Flavia Rubia Pallis, Carla Fernanda Franco-Penteado, Joyce Maria Annichino-Bizzacchi, Fernando Ferreira Costa, Erich Vinicius de Paula, Sara Terezinha Olalla-Saad, Fabiola Traina
Journal: Blood (2013)
The Prospects for Cardiovascular Proteomics
Authors: Mark D. Benson, Marc S. Sabatine, Robert E. Gerszten
Journal: JAMA Cardiology (2016)

This Viewpoint examines strategies currently used in proteomic biomarker research and highlights advances that are beginning to provide describe how proteomics may move beyond the early stages of development and be applied to large-scale, population-based studies.
Communicating with patients
Authors: N. Steel, R. E Taylor
Journal: BMJ (1999)

Editor—Blennerhassett eloquently describes the horrors of her treatment for anal cancer.1 Her story is shocking but depressingly familiar from other patients’ accounts of their treatment. The difference in the two commentaries published with the account throws some light on why these stories keep appearing.

The well referenced and scientific response from the cancer specialists Tattersall and Ellis reminded me of Andre Gide’s remark that a person attempting to understand life by merely using his reason is like a man trying to take hold of a flame with the tongs. Blennerhassett’s account does more than exemplify “the often slow and reluctant response of the medical profession to health ‘consumerism.’” It powerfully describes the brutal results of poor communication. Tattersall and Ellis extinguish the flame of this message by trying to take hold of it with the tongs of science. The impact of the message is all but lost when the impersonal language of science is used: “Communication with the patient during consultation ... is an important and sometimes overlooked component of optimal and efficient cancer care.”

A different approach is taken by Metcalfe, formerly a professor of general practice, who does not use science to deflect Blennerhassett’s emotional message. He acknowledges that the account “was a journey through hell” and that something went wrong. He addresses the need for changes in postgraduate training and makes useful suggestions for ways to approach consultations. He manages without a single academic reference. And so my stereotypes are confirmed: the generalist writes about the art of medicine and the specialists, the science.

The problem is, as Aneurin Bevan almost said, that I would rather have my cancer brutally but effectively treated than expire in a gush of sympathy. Is that stark choice from the 1940s still here, or can high technology and effective medical treatment now be delivered with understanding? Postgraduate training in communication skills is taken seriously in general practice. When will it be taken seriously in specialist training?
TCTAP A-150 Comparison of Second- and First-Generation Drug Eluting Stent for Percutaneous Coronary Chronic Total Occlusion Intervention
Authors: Min Soo Cho, Seung-Jung Park, Seong-Wook Park, Cheol Whan Lee, Young-Hak Kim, Seung-Whan Lee, Duk-Woo Park, Soo-Jin Kang, Jung-Min Ahn, Pil Hyung Lee, Se Hun Kang, Cheol Hyun Lee, Jae Seok Bae, Yu Na Kim, Sung Han Yoon, Mineok Chang, Do-Yoon Kang
Journal: Journal of the American College of Cardiology (2016)
Protein Metabolism After Injury
Authors: A FLECK, H N MUNRO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
TCTAP A-098 Fractional Myocardial Mass: A Novel Index for the Severity and Extent of Ischemic Burden in Coronary Artery Disease - Functional Severity of Coronary Artery Stenosis Depends on the Amount of Myocardial Mass Subtended by the Coronary Artery Stenosis
Authors: Hyung Yoon Kim, Jin-Ho Choi, Joon Hyung Doh, Hong-Seok Lim, Chang-Wook Nam, Bon-Kwon Koo, Young Bin Song, Joo-Yong Hahn, Seung Hyuk Choi, Hyeon-Cheol Gwon
Journal: Journal of the American College of Cardiology (2016)
Cardiac function after open heart surgery: Relation between the performance of the two sides of the heart
Authors: B. S. JENKINS, M. A. BRANTHWAITE, R. D. BRADLEY
Journal: Cardiovascular Research (1973)

The relation between right and left atrial pressures and stroke volume and stroke work for both ventricles was investigated in the immediate postoperative period in nine patients after cardiac surgery. Low values for stroke index and stroke work index were found and little change occurred with alterations in atrial pressures. Isoprenaline caused significant increases in both indices and, together with its effect on heart rate, considerable rises in cardiac index and left ventricular stroke work index. The analysis of the simultaneous relation between the function of the two sides of the heart was found to be an important guide to patient management and cannot be predicted from the preoperative diagnosis after cardiopulmonary bypass.
High specificity of a novel Zika virus ELISA in European patients after exposure to different flaviviruses
Authors: Daniela Huzly, Ingeborg Hanselmann, Jonas Schmidt-Chanasit, Marcus Panning
Journal: Eurosurveillance (2016)

The current Zika virus (ZIKV) epidemic in the Americas caused an increase in diagnostic requests in European countries. Here we demonstrate high specificity of the Euroimmun anti-ZIKV IgG and IgM ELISA tests using putative cross-reacting sera of European patients with antibodies against tick-borne encephalitis virus, dengue virus, yellow fever virus and hepatitis C virus. This test may aid in counselling European travellers returning from regions where ZIKV is endemic.
Abstract 19972: Validation of the Universal Definition of Type 4a Myocardial Infarction with High Sensitivity Troponin T in Patients with Non-ST Elevation Acute Coronary Syndrome Undergoing Percutaneous Coronary Interventions
Authors: Kevin Liou, Petrina Kellar, Ben Ng, Julia Isbister, Robert Giles, Nigel Jepson, Daniel Friedman, Roger Allan, Antony Lau, Mark Pitney, Sze-Yuan Ooi
Journal: Circulation (2014)

Introduction:  The current Universal Definition of peri-procedural myocardial infarction (PMI) in patients with NSTEACS is arbitrary and remains unsubstantiated by clinical trials. Its relevance in the era of high sensitivity troponin (hsTn) is also undetermined. Validation of this definition with hsTn would therefore have significant implications both for outcome assessment in scientific trials and clinical practice.   Methods:  High sensitivity troponin T (hsTnT; Roche Diagnostics; 99th percentile 14ng/L) was introduced at our institution in March 2011. A review of our prospective cohort between May 2011 and April 2012 was performed and outcome data obtained. Patients with NSTEACS undergoing PCI with normal, stable or declining pre-procedural hsTnT were included for analysis.   Results:  Of the 221 patients who underwent PCI for NSTEACS during the study period, one hundred and ninety six patients (88.7%) were eligible for analysis. Among them 71% were male, while the mean age was 68.0(+/-11.6). Forty-one percent had NSTEMI, while the rest had UAP. At angiography, single, double and triple vessel diseases were found in 58.2%, 30.1% and 5.1%, respectively. Procedural success was achieved in 98.9%. PMI occurred in 5.6% of the patients based on the Universal Definition. The only predictor of PMI was female sex (OR 4.7; 95% CI 1.3-16.8, p=0.017). Follow up was available in 94.9% at 12 months. MACE (MI, death and revascularisation) occurred in 6.5%. In a multivariate model, PMI was significantly associated with MACE (OR 6.6, 95% CI 1.2-36.9, p=0.03). This was driven primarily by the need for revascularisation. Neither peri-procedural changes in hsTnT nor clinical signs in isolation were predictive of MACE. The absolute level of post procedural hsTnT was significantly higher in those with MACE (Median 320 v.s. 54 ng/L, p = 0.004), and was a fair predictor of MACE at 12 months (AUC = 0.75).   Conclusions:  Post procedural hsTnT as a cumulative measure of spontaneous and PCI related myonecrosis is associated with worse clinical outcome at 12 months in patients with NSTEACS undergoing PCI. In addition, PMI as defined by current Universal Definition using hsTnT is an independent contributor to this risk, and remains a key outcome measure in clinical trials and a target for therapy.
Targeted siRNA Delivery Using a Lipo‐Oligoaminoamide Nanocore with an Influenza Peptide and Transferrin Shell
Authors: Wei Zhang, Katharina Müller, Eva Kessel, Sören Reinhard, Dongsheng He, Philipp M. Klein, Miriam Höhn, Wolfgang Rödl, Susanne Kempter, Ernst Wagner
Journal: Advanced Healthcare Materials (2016)

Developing RNA‐interference‐based therapeutic approaches with efficient and targeted cytosolic delivery of small interfering RNA (siRNA) is remaining a critical challenge since two decades. Herein, a multifunctional transferrin receptor (TfR)‐targeted siRNA delivery system (Tf&amp;INF7) is designed based on siRNA complexes formed with the cationic lipo‐oligoamino amide 454 , sequentially surface‐modified with polyethylene glycol‐linked transferrin (Tf) for receptor targeting and the endosomolytic peptide INF7 for efficient cytosolic release of the siRNA. Effective Tf&amp;INF7 polyplex internalization and target gene silencing are demonstrated for the TfR overexpressing tumor cell lines (K562, D145, and N2a). Treatment with antitumoral EG5 siRNA results in a block of tumor cell growth and triggered apoptosis. Tf‐modified polyplexes are far more effective than the corresponding albumin‐ (Alb) or nonmodified 454 polyplexes. Competition experiments with excess of Tf demonstrate TfR target specificity. As alternative to the ligand Tf, an anti‐murine TfR antibody is incorporated into the polyplexes for specific targeting and gene silencing in the murine N2a cell line. In vivo distribution studies not only demonstrate an enhanced tumor residence of siRNA in N2a tumor‐bearing mice with the Tf&amp;INF7 as compared to the 454 polyplex group but also a reduced siRNA nanoparticle stability limiting the in vivo performance.
Abstract 3353: Prostate cancer microenvironment modulates macrophage phagocytosis
Authors: Evita G. Weagel, Nicholas B. Anderson, Wei Meng, Josh Davis, Richard A. Robison, Kim L. O'Neill
Journal: Cancer Research (2015)

Abstract Macrophages play an important role in the body's immune system. There are two main phenotypes of macrophages, M1 and M2. M1 polarized macrophages participate in tumorcidal activity and pro-inflammatory responses. M2 macrophages perform anti-inflammatory responses and promote tissue repair, angiogenesis, and tumor growth. Macrophages within the vicinity of cancer cells may be influenced by the microenvironment and change their gene expression accordingly. Macrophages can express different cytokine profiles depending on their polarization state (M1 or M2). We investigated whether macrophages exposed to cancer cells demonstrate a M2 or M1 phenotype. We stimulated U937 cells with phorbol 12-myristate 13-acetate (PMA) for 24 hours to allow for adhesion and differentiation. We co-cultured PMA-stimulated U937 macrophages with PC3 and DU145 prostate cancer cell lines in a 1:1 ratio with a transpermeable membrane to allow for cell to cell contact and communication, and with PC3 and DU145 conditioned media for 48 hours. We isolated the RNA from the treated macrophages and performed qPCR to assess gene expression levels of the following cytokines: IL-10, a cytokine demonstrating a M2 phenotype was upregulated by 10 and 15 fold for PC3 and DU145 cells respectively and by 3 fold in both cell lines exposed to conditioned media. We also found a trend of downregulation with the cytokines IL-1, IL-12, and TNF - alpha, which also depict a M2 phenotype. We also assessed macrophage function by measuring engulfment by flow cytometry. Treated macrophages were allowed to phagocytose fluorescent microbeads for 1 hour. Flow cytometry analysis revealed that total bead engulfment decreased by up to 80% in macrophages treated with PC3 cells. Moreover, the population of macrophages that engulfed 3+ beads decreased significantly from both the cells and media treatments. Macrophages treated with DU145 cells and spent media also showed a similar trend to macrophages exposed to PC3 cells. The results show that macrophages exposed to PC3 and DU145 cancer cell lines polarized towards an M2 phenotype and could be important in the success of cancer within the microenvironment. Further research will reveal whether this process of a M2 polarization of macrophages is mediated by cytokines and cell vesicles or other factors. Citation Format: Evita G. Weagel, Nicholas B. Anderson, Wei Meng, Josh Davis, Richard A. Robison, Kim L. O'Neill. Prostate cancer microenvironment modulates macrophage phagocytosis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3353. doi:10.1158/1538-7445.AM2015-3353
Results of a Phase III Randomized, Multi-Center Study of Allogeneic Stem Cell Transplantation after High Versus Reduced Intensity Conditioning in Patients with Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML): Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0901
Authors: Bart L Scott, Marcelo C. Pasquini, Brent Logan, Juan Wu, Steve Devine, David L Porter, Richard T. Maziarz, Erica Warlick, Hugo F. Fernandez, Edwin P. Alyea, Mehdi Hamadani, Asad Bashey, Sergio A. Giralt, Eric Leifer, Nancy Geller, Jennifer Le-Rademacher, Adam M. Mendizabal, Mary M. Horowitz, H. Joachim Deeg, Mitchell E. Horwitz
Journal: Blood (2015)
Impaired Function of Macrophage Fcγ Receptors and Bacterial Infection in Alcoholic Cirrhosis
Authors: Francisco Gomez, Pedro Ruiz, Alan D. Schreiber
Journal: New England Journal of Medicine (1994)

Bacterial infection is a frequent and often fatal complication in patients with cirrhosis. Macrophages play an important part in the host defense against infection because their Fcγ receptors recognize antibody-coated bacteria.
A new prognostic score in patients with malignant pleural mesothelioma.
Authors: G. Selvaggi, A. Billè, M. Gisabella, L. Righi, L. Errico, P. Borasio, F. Ardissone
Journal: Journal of Clinical Oncology (2010)

7039 Background: Available prognostic scores in malignant pleural mesothelioma (MPM) are based on multiple variables with conflicting results. The aims of the study were to identify prognostic factors for survival and create a new prognostic score including macroscopic features of pleural surfaces in patients with MPM. Methods: Retrospective study of 455 consecutive patients (307 men, 67.5%; 148 women, 32.5%; median age 66; range 28-93) with histologically proven MPM who underwent diagnostic thoracoscopy or open pleural biopsy between January 1990 and December 2007. Patients received either chemotherapy or best supportive care. All patients were followed up until death or for a minimum period of 2 years. Kaplan-Meier method, log-rank test, Cox model, and maximum-likelihood parameter estimates were used in the statistical analysis. Results: As of December 2009, 439 patients (96.5%) had died (median survival [MS], 11.7 months, range 0.3-118; 2-year survival rate 18.9%). Median follow-up of 16 surviving patients (3.5%) was 48.1 months (range 26.5-106.8). At multivariate analysis, factors independently associated with decreased survival included: poor performance status, presence of chest pain, non-epithelial cell type, visceral pleura involvement, and diffuse involvement of pleural cavity (more than one third of the cavity). On the basis of these five factors, patients were classified into three prognostic groups: a good-prognosis group (MS, 30.4 months, 95% confidence interval [CI] 17.4-42.6; 2-year survival rate 58.3%), an intermediate-prognosis group (MS, 12.3 months, 95% CI 10.7-13.8; 2-year survival rate 19.6%), and a poor-prognosis group (MS, 7.5 months, 95% CI 5.2-9.8; 2-year survival rate 7.6%) (p = 0.000001). Conclusions: This score defines three homogeneous prognostic groups and may be used to stratify patients with MPM when designing prospective clinical studies based on multimodality treatment or new biological agents. No significant financial relationships to disclose.
TCTAP A-085 The Efficacy and Safety of Using the Septal Artery from Non-Left Anterior Descending Coronary Artery for Alcohol Septal Myocardial Ablation
Authors: Yoshiaki Kawase, Tetsuo Hirata, Akihiro Hirakawa, Syuuichi Okamoto, Hiroyuki Omori, Yoshihiro Nakatani, Jun Kikuchi, Hideaki Ota, Tatsuya Saigusa, Taiji Miyake, Itta Kawamura, Munenori Okubo, Kunihiko Tsuchiya, Hitoshi Matsuo
Journal: Journal of the American College of Cardiology (2016)
Letter by Murakami and Nawa Regarding Article, “Bilateral Superior Venae Cavae With Crisscross Atrial Drainage”
Authors: Tomoaki Murakami, Tomohiro Nawa
Journal: Circulation (2016)

We read with great interest the article by Tripathi and colleagues 1 that reported the anomalous connection of the right superior vena cava (RSVC) to the left atrium (LA) and the left superior vena cava (LSVC) draining into the right atrium via the coronary sinus in a patient with sick sinus syndrome.It is an extremely rare anomaly.The authors diagnosed the patient as having an "RSVC draining into the LA and persistent LSVC (PLSVC) draining into the right atrium (RA) with symptomatic sinus node dysfunction."The diagnosis is adequate judging from the hemodynamics.However, we consider that it is inappropriate as the anatomic diagnosis.Embryologically, the LSVC draining to the LA via the coronary sinus can be explained as the persistent left cardinal vein.However, the RSVC draining to the LA is incapable of being accounted for without some kind of defect.Actually, the computed tomography image showed that the RSVC connected not to the LA but to the right upper pulmonary vein.Therefore, the anatomic diagnosis of the patient is sinus venosus defect without (or with atretic) RSVC-RA connection and PLSVC. 2 It is strange that the patient did not experience cyanosis.As the authors say, it could be explained by the existence of an azygos vein.The azygos vein usually exists distal to the sinus venous defect, and the computed tomography image proved the existence of the azygos vein.Therefore, the venous return from the right upper body could be partly drained to the inferior vena cava via the azygos vein.However,