tbuckley/cabot-search huggingface dataset:
Rehabilitation of the Disabled
Authors: T E HOLLAND
Journal: New England Journal of Medicine (1943)

The world war has aroused a universal interest in the physical and mental rehabilitation of disabled sol- diers.The instruments of destruction of modern warfare sacrificed millions of lives and disabled a multitude of men.To conserve man power it became necessary for the European countries engaged in the war to study and apply all possible measures to protect the lives and health of the soldier.The use by the central powers of offensive and destructive measures in the way of high explosives, poisonous gases, liquid fire and other devices produced injuries requiring special measures of pre- vention and efficient surgical and medical manage- ment which could be developed only after careful re- search and study.The final year of the war was illuminated by remarkable results of the practical application of known and new measures of prevention of disease, and military surgery reached a stage of tech- nical skill and efficiency heretofore unknown. EUROPEAN METHODS OF REHABILITATIONIn addition to ordinary medical and surgical care, all the European countries engaged in the war adopted measures to hasten physical and functional restoration by the application of special therapeutic measures grouped under the heading of physical and mental reconstruction or rehabilitation.The program of rehabilitation included physio¬ therapy, embracing hydrotherapy, electrotherapy and Read before the Institute of Medicine of Chicago, April 19, 1919.
Insulin Response and Glucose-C14 Disappearance Rate During the Glucose Tolerance Test in the Unanesthetized Dog
Authors: Y ARNOULD, R BELLENS, J R FRANCKSON, V CONARD
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Stress reactivity in bipolar patients and its relation to prior history of disorder
Authors: C Hammen, M Gitlin
Journal: American Journal of Psychiatry (1997)

Two questions were posed: Does stress precipitate episodes of bipolar I disorder, and does sensitivity to stress differ in episodes later in the course of illness compared to early ones?Fifty-two patients with bipolar I disorder were followed longitudinally for up to 2 years; clinical course was monitored, and interview assessments of life events were made every 3 months.The patients who had episodes of illness during follow-up had experienced significantly more severe stressors and more total stress in the preceding 6 months, and more total stress in the preceding 3 months, than those without episodes. Inconsistent with Post's stress "sensitization" hypothesis, patients with more prior episodes were more likely to have episodes following major stressors, and they relapsed more rapidly.Stressors may precipitate episodes of bipolar illness, especially for patients with more prior episodes. Different versions of the stress sensitization model remain to be tested.
Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma
Authors: Rebecca L. Boddicker, Gina L. Razidlo, Surendra Dasari, Yu Zeng, Guangzhen Hu, Ryan A. Knudson, Patricia T. Greipp, Jaime I. Davila, Sarah H. Johnson, Julie C. Porcher, James B. Smadbeck, Bruce W. Eckloff, Daniel D. Billadeau, Paul J. Kurtin, Mark A. McNiven, Brian K. Link, Stephen M. Ansell, James R. Cerhan, Yan W. Asmann, George Vasmatzis, Andrew L. Feldman
Journal: Blood (2016)
Cultural variant interaction in teaching and transmission
Authors: Marshall Abrams
Journal: Behavioral and Brain Sciences (2015)

Abstract Focus on the way in which cultural variants affect other variants' probabilities of transmission in modeling and empirical work can enrich Kline's conceptualization of teaching. For example, the problem of communicating complex cumulative culture is an adaptive problem; teaching methods that manage transmission so that acquisition of some cultural variants increases the probability of acquiring others, provide a partial solution.
Risk of hepatotoxicity with concurrent statin and tyrosine kinase inhibitor (TKI) or mTOR inhibitor (mTORi) in patients with metastatic renal cell carcinoma (mRCC).
Authors: Trang H. Au, Erin B. Bailey, Shiven B. Patel, Srinivas Kiran Tantravahi, Neeraj Agarwal, David D. Stenehjem
Journal: Journal of Clinical Oncology (2016)

610 Background: TKIs and statins alone can cause liver injury. When used together, there is additive risk for hepatotoxicity, as seen with pazopanib and simvastatin, and the potential for discontinuing TKI therapy. Liver enzyme abnormalities are also associated with mTORi. Hepatotoxicity from concurrent use of statins as a class with TKI or mTORi as a class in real world practice in mRCC has not been reported. Methods: This observational cohort study included adult patients treated with a TKI or mTORi for mRCC at the Huntsman Cancer Institute from 2004-2014. We performed a treatment line analysis. For each treatment line, CTCAE criteria were used to categorize maximum AST, ALT, and total bilirubin. Highest grade of any liver enzyme was compared between TKI with and without statin and between mTORi with and without statin (Fisher’s Exact test). Results: A total of 162 treatment lines were included. For TKI and statin, the three most common treatment line combinations were sunitinib and simvastatin (7), sunitinib and atorvastatin (4), and pazopanib and simvastatin (3). For mTORi and statin, the three most common treatment line combinations involved simvastatin with temsirolimus (7) and everolimus (3). Prevalence of hepatotoxicity is shown in the table. Conclusions: Our results show a trend toward significance in the prevalence of hepatotoxicity with concomitant mTORi and statin versus mTORi alone, perhaps explained by mTORi-mediated competitive inhibition of simvastatin (sensitive CYP 3A4 substrate). There was no difference in hepatotoxicity for TKI with or without statin, although there were few pazopanib and simvastatin combinations. Study limitations include the small sample size, limited number of TKI or mTORi and statin combinations, and retrospective study design. A larger study is needed to validate these findings. [Table: see text]
Washington
Authors: M. Therese Southgate
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Autologous bone marrow transplantation in high-risk remission T-lineage acute lymphoblastic leukemia using immunotoxins plus 4- hydroperoxycyclophosphamide for marrow purging
Authors: FM Uckun, JH Kersey, DA Vallera, JA Ledbetter, D Weisdorf, DE Myers, R Haake, NK Ramsay
Journal: Blood (1990)
Therapy for Colorectal Cancer
Authors: N Kemeny, K Seiter
Journal: New England Journal of Medicine (2005)

Recent advances in systemic therapy involve the biochemical modulation of fluorouracil. New trials combining either leucovorin or N-(phosphonoacetyl)-L-aspartate (PALA) with fluorouracil have demonstrated increased response rates. Recent trials of interferon-alpha with fluorouracil have not confirmed the high response rates reported in previous trials. Advances in regional therapy include the addition of either leucovorin or systemic therapy to fluorodeoxyuridine. Some adjuvant trials of portal vein infusion have shown increased survival, though the incidence of liver metastases was not decreased. A large adjuvant trial in rectal cancer demonstrated improved survival and decreased local recurrences when fluorouracil and methyl-CCNU were added to radiation therapy.
Psychodynamic variables as predictors of psychotherapy outcome
Authors: P Buckley, H R Conte, R Plutchik, K V Wild, T B Karasu
Journal: American Journal of Psychiatry (1984)

Predicting the outcome of psychotherapy is a central concern in psychiatry. Twenty-one medical students seeking psychotherapy were evaluated on a number of psychodynamic and process variables using self-report scales and scales completed by the therapist before, during, and after psychotherapy. There were significant differences between patients and a comparison group on eight variables before therapy. Ten psychodynamic variables (six representing ego defense mechanisms) and four process variables were found to be highly correlated with outcome measures; the process variables were the best predictors of outcome. The data support the use of psychodynamic and process variables as predictors of outcome in psychoanalytically oriented psychotherapy.
AT-07PLK1 AS A THERAPEUTIC TARGET IN ATRT
Authors: Irina Alimova, Angela M. Pierce, Sujatha Venkataraman, Peter Harris, Diane K. Birks, Vladimir M. Amani, Eric Prince, Ilango Balakrishnan, Nicholas K. Foreman, Rajeev Vibhakar
Journal: Neuro-Oncology (2016)
Cancer of the esophagus: a brighter future?
Authors: S Hellman
Journal: Journal of Clinical Oncology (1984)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1984.2.2.73 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 6699665 Cancer of the esophagus: a brighter future? S HellmanxS HellmanSearch for articles by this author https://doi.org/10.1200/JCO.1984.2.2.73 PDF "Cancer of the esophagus: a brighter future?." Journal of Clinical Oncology, 2(2), pp. 73–74© 1984 by American Society of Clinical Oncology
Staphylococcus aureus and MRSA in Austrian hospitals, 1995
Authors: W Koller
Journal: Eurosurveillance (1997)

In 1996, 327 acute care hospitals and other health care institutions in Austria were asked by the Federal Ministry of Health and Consumer Protection to report the number of inpatient episodes in 1995 in which Staphylococcus aureus (SA) was cultured. The m
Case 11-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Robert H. Schapiro, Austin L. Vickery
Journal: New England Journal of Medicine (1978)

Presentation of CaseA 52-year-old man was admitted to the hospital because of melena.He was well until three days earlier, when he began to experience a "queasy" sensation. On the following day he felt weak and observed that his stools were dark. Two days later he saw his physician, who admitted him to the hospital.There was a history of hypochromic anemia that required several transfusions at the age of 17 years and again at 30 years. Pyridoxine was prescribed, and anemia did not recur. One year before admission he was given allopurinol and colchicine because of gout. He . . .
Hypnotic alteration of somatosensory perception
Authors: D Spiegel, P Bierre, J Rootenberg
Journal: American Journal of Psychiatry (1989)

Effects of hypnotic alterations of perception on amplitude of somatosensory event-related potentials were studied in 10 highly hypnotizable subjects and 10 subjects with low hypnotizability. The highly hypnotizable individuals showed significant decreases in amplitude of the P100 and P300 waveform components during a hypnotic hallucination that blocked perception of the stimulus. When hypnosis was used to intensify attention to the stimulus, there was an increase in P100 amplitude. These findings are consistent with observations that highly hypnotizable individuals can reduce or eliminate pain by using purely cognitive methods such as hypnosis. Together with data from the visual system, these results suggest a neurophysiological basis for hypnotic sensory alteration.
Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis
Authors: N A Smart, N King, J R McFarlane, P L Graham, G Dieberg
Journal: British Journal of Sports Medicine (2016)

Exercise training has been shown to have beneficial effects on liver function in adults overweight or with fatty liver disease. To establish which exercise programme characteristics were likely to elicit optimal improvements.Systematic review and meta-analysis of randomised, controlled trials.PubMed, CINAHL and Cochrane controlled trials registry searched (1966 to 2 October 2015).Exercise intervention, with or without dietary intervention, versus usual care in adults undertaking, exercise training, who were overweight, obese or exhibited fatty liver disease (non-alcoholic fatty liver disease or non-alcoholic steatohepatitis).We included 21 randomised controlled trials, totalling 1530 participants. Exercise intervention studies with total exercise programme workload >10 000 kcal produced significant improvements in intrahepatic fat, -3.46% (95% CI -5.20% to -1.73%), p<0.0001, I2=73%; effect size (standardised mean difference, SMD) -1.77 (-3.11 to -0.42), p=0.01, I2=77%. When data from only exercise studies were pooled, there was a reduction in fasting free fatty acids (FFAs) -74.15 µmol/L (95% CI -118.47 to -29.84), p=0.001, I2=67% with a large effect size (SMD) -0.94 (-1.36 to -0.52), p<0.0001, I2=0%. When data from only exercise studies were pooled, there was a significant reduction in insulin MD -1.88 UL (95% CI -3.43 to -0.34), p=0.02, I2=31%. The liver enzymes, alanine aminotransferase, aspartate aminotransferase and γ-glutamyl transpeptidase, were not significantly altered with exercise.Exercise training reduces intrahepatic fat and FFAs while increasing cardiorespiratory fitness. An aggregate exercise programme energy expenditure (>10 000 kcal) may be required to promote reductions in intrahepatic fat.
Relationship of cognitive factors to CSF corticotropin-releasing hormone in depression
Authors: J A De Jong, A Roy
Journal: American Journal of Psychiatry (1990)

The authors investigated the relationship between items on the Beck Depression Inventory and CSF levels of corticotropin-releasing hormone (CRH) in 17 depressed patients. Linear regression analysis showed that self-accusation, expectation of punishment, and crying accounted for 82% of CRH variance.
Six Imprisoned Health-Care Workers in Libya Are Pawns in a Far Larger Strategic Game
Authors: Laurie Garrett
Journal: PLoS Medicine (2006)

The scientific community, AIDS activists, and the Libyan government would do well to recognize that the political and diplomatic import of the case of the Benghazi Six involves a great deal more than the lives of five Bulgarian nurses and a Palestinian physician. At stake are some of the most profound political issues of our time: terrorism, nuclear proliferation, the freedom of movement of health-care workers and scientists, and the Biological Weapons Convention. Although human rights advocates rightly decry the physical torture these individuals have been subjected to, and their death sentences, it is critical to recognize that the unfortunate Benghazi Six—Bulgarian nurses Snezhana Dimitrova, Nasya Nenova, Valentina Siropulo, Valya Chervenyashka, and Kristiyana Valtcheva, and Palestinian physician Ahmed Ashraf Al Hadjudi—are pawns in a far larger game.
MB-74LOWER SOCIAL ACCEPTANCE MAKES CURED PATIENTS MORE UNHAPPY THAN PHYSICAL CONSEQUENCES OF METASTATIC MEDULLOBLASTOMA
Authors: Laura Veneroni, Luna Boschetti, Carlo Alfredo Clerici, Fabio Simonetti, Elisabetta Schiavello, Veronica Biassoni, Filippo Spreafico, Lorenza Gandola, Maura Massimino
Journal: Neuro-Oncology (2016)
Dizziness and falling in elderly psychiatric outpatients
Authors: M D Blumenthal, J W Davie
Journal: American Journal of Psychiatry (1980)

The authors examined 100 psychiatric patients who were 60 years old and older for orthostatic hypotension and symptoms of dizziness and falling. Almost 40% of the patients complained of dizziness and falling, although only 27% had systolic orthostatic hypotension. Drug treatment, particularly the combination of tricyclics with other orthostatic hypotension-inducing drugs, was the most important factor accounting for the dizziness and falling. Underlying medical illness, particularly heart disease, also correlated significantly with the patients' symptoms.
145O Phase II study of AZD4547 in FGFR amplified tumours: gastroesophageal cancer (GC) cohort clinical and translational results
Authors: E.C. Smyth, N. Turner, A. Pearson, C. Peckitt, I. Chau, D. Watkins, E. Kilgour, N.R. Smith, A. Gillbanks, S. Chua, G. Brown, R. Cutts, C. Rooney, N. Tarazona Llavero, A. Thomas, S. Popat, D. Cunningham
Journal: Annals of Oncology (2015)
Delayed perforation caused by an endoscopic clip following uncomplicated endoscopic resection of a large sporadic nonampullary duodenal adenoma
Authors: Moritz von Wulffen, Alexander Huelsen, Tom O’Rourke, Nivene Saad, Saurabh Gupta
Journal: Endoscopy (2016)

A 42-year-old woman was referred for resection of a sporadic, 60-mm, high grade tubulovillous adenoma in the descending duodenum ([Fig. 1]). Submucosal injection of gelofusine, methylene blue, and diluted adrenaline ([Fig. 2]) was followed by piecemeal endoscopic mucosal resection (EMR) using an EVIS EXERA II 180 duodenoscope (Olympus, Tokyo, Japan) and snare (SnareMaster SD-230U-20; Olympus). Minor bleeding from vessels along the lateral resection margin settled spontaneously, and two clips (Instinct Hemoclip; Cook Medical, Limerick, Ireland) were placed, taking care to grasp adjacent mucosa ([Fig. 3]). The EMR site was carefully re-inspected and no further bleeding was observed.
TB-14THE INFORM PERSONALIZED MEDICINE STUDY - NEW MOLECULAR INSIGHTS INTO RELAPSED PEDIATRIC BRAIN TUMORS
Authors: Barbara C. Worst, Cornelis M. van Tilburg, Gnana Prakash Balasubramanian, Petra Fiesel, Elke Pfaff, Ruth Witt, Angelika Freitag, Andreas von Deimling, Angelika Eggert, Peter Lichter, David Capper, Olaf Witt, Stefan M. Pfister, David T.W. Jones
Journal: Neuro-Oncology (2016)
Medicinal Chemistry Strategies to Disrupt the p53–MDM2/MDMX Interaction
Authors: Agostinho Lemos, Mariana Leão, Joana Soares, Andreia Palmeira, Madalena Pinto, Lucília Saraiva, Maria Emília Sousa
Journal: Medicinal Research Reviews (2016)

Abstract The growth inhibitory activity of p53 tumor suppressor is tightly regulated by interaction with two negative regulatory proteins, murine double minute 2 (MDM2) and X (MDMX), which are overexpressed in about half of all human tumors. The elucidation of crystallographic structures of MDM2/MDMX complexes with p53 has been pivotal for the identification of several classes of inhibitors of the p53–MDM2/MDMX interaction. The present review provides in silico strategies and screening approaches used in drug discovery as well as an overview of the most relevant classes of small‐molecule inhibitors of the p53–MDM2/MDMX interaction, their progress in pipeline, and highlights particularities of each class of inhibitors. Most of the progress made with high‐throughput screening has led to the development of inhibitors belonging to the cis ‐imidazoline, piperidinone, and spiro‐oxindole series. However, novel potent and selective classes of inhibitors of the p53–MDM2 interaction with promising antitumor activity are emerging. Even with the discovery of the 3D structure of complex p53–MDMX, only two small molecules were reported as selective p53–MDMX antagonists, WK298 and SJ‐172550. Dual inhibition of the p53–MDM2/MDMX interaction has shown to be an alternative approach since it results in full activation of the p53‐dependent pathway. The knowledge of structural requirements crucial to the development of small‐molecule inhibitors of the p53–MDMs interactions has enabled the identification of novel antitumor agents with improved in vivo efficacy.
Dogs are man's best friend: in sickness and in health
Authors: R. Timothy Bentley, Atique U. Ahmed, Amy B. Yanke, Aaron A. Cohen-Gadol, Mahua Dey
Journal: Neuro-Oncology (2016)

With the median survival of 14.6 months following best available standard of care, malignant gliomas (MGs) remain one of the biggest therapeutic challenges of the modern time. Although the last several decades have witnessed tremendous advancement in our understanding of MG and evolution of many successful preclinical therapeutic strategies, even the most successful preclinical therapeutic strategies often fail to cross the phase I/II clinical trial threshold. One of the significant, but less commonly discussed, barriers in developing effective glioma therapy is the lack of a robust preclinical model. For the last 30 years, rodent orthotopic xenograft models have been extensively used in the preclinical setting. Although they provide a good basic model for understanding tumor biology, their value in successfully translating preclinical therapeutic triumph into clinical success is extremely poor. Companion dogs, which share the same environmental stress as their human counterparts, also spontaneously develop MGs. Dog gliomas that develop spontaneously in an immunocompetent host are very similar to human gliomas and potentially provide a stronger platform for validating the efficacy of therapeutic strategies proven successful in preclinical mouse models. Integrating this model can accelerate development of effective therapeutic options that will benefit both human subjects and pet dogs.
Myths of "shock therapy"
Authors: M Fink
Journal: American Journal of Psychiatry (1977)

The author discusses the myths of the ECT process--that shock and the convulsion are essential, memory loss and brain damage are inescapable, and little is known of the process--and assesses the fallacies in these ideas. Present views of the ECT process suggest that its mode of action in depression may best be described as a prolonged form of diencephalic stimulation, particularly useful to affect the hypothalamic dysfunctions that characterize depressive illness. The author emphasizes the need for further study of this treatment modality and for self-regulation by the profession.