tbuckley/cabot-search huggingface dataset:
Protective Prevention Effects on the Association of Poverty With Brain Development
Authors: Gene H. Brody, Joshua C. Gray, Tianyi Yu, Allen W. Barton, Steven R. H. Beach, Adrianna Galván, James MacKillop, Michael Windle, Edith Chen, Gregory E. Miller, Lawrence H. Sweet
Journal: JAMA Pediatrics (2016)

<h3>Importance</h3> This study was designed to determine whether a preventive intervention focused on enhancing supportive parenting could ameliorate the association between exposure to poverty and brain development in low socioeconomic status African American individuals from the rural South. <h3>Objective</h3> To determine whether participation in an efficacious prevention program designed to enhance supportive parenting for rural African American children will ameliorate the association between living in poverty and reduced hippocampal and amygdalar volumes in adulthood. <h3>Design, Setting, and Participants</h3> In the rural southeastern United States, African American parents and their 11-year-old children were assigned randomly to the Strong African American Families randomized prevention trial or to a control condition. Parents provided data used to calculate income-to-needs ratios when children were aged 11 to 13 years and 16 to 18 years. When the participants were aged 25 years, hippocampal and amygdalar volumes were measured using magnetic resonance imaging. <h3>Exposures</h3> Household poverty was measured by income-to-needs ratios. <h3>Main Outcomes and Measures</h3> Young adults’ whole hippocampal, dentate gyrus, and CA3 hippocampal subfields as well as amygdalar volumes were assessed using magnetic resonance imaging. <h3>Results</h3> Of the 667 participants in the Strong African American Families randomized prevention trial, 119 right-handed African American individuals aged 25 years living in rural areas were recruited. Years lived in poverty across ages 11 to 18 years forecasted diminished left dentate gyrus (simple slope, −14.20; standard error, 5.22;<i>P</i> = .008) and CA3 (simple slope, −6.42; standard error, 2.42;<i>P</i> = .009) hippocampal subfields and left amygdalar (simple slope, −34.62; standard error, 12.74;<i>P</i> = .008) volumes among young adults in the control condition (mean [SD] time, 2.04 [1.88] years) but not among those who participated in the Strong African American Families program (mean [SD] time, 2.61 [1.77] years). <h3>Conclusions and Relevance</h3> In this study, we described how participation in a randomized clinical trial designed to enhance supportive parenting ameliorated the association of years lived in poverty with left dentate gyrus and CA3 hippocampal subfields and left amygdalar volumes. These findings are consistent with a possible role for supportive parenting and suggest a strategy for narrowing social disparities.
Increased Endothelial Colony-Forming Cells (ECFC) and Endothelial Microparticles (EMP) and Their Interaction in Thrombotic Thrombocytopenic Purpura (TTP).
Authors: Joaquin J. Jimenez, Wenche Jy, Lucia M. Mauro, Loreta Bidot, Luis M. Salgueiro, David Andrews, Sherry Shariatmadar, Lawrence L. Horstman, Vincenzo Fontana, Yeon-Soong Ahn
Journal: Blood (2007)
Treatment of Patients with Relapsed/Refractory Multiple Myeloma (MM) with Lenalidomide and Dexamethasone with or with Bortezomib Depending on Prior Neurotoxicity: Prospective Evaluation of the Impact of Cytogenetic Abnormalities and Assessment of Bone Met.
Authors: Meletios A. Dimopoulos, Efstathios Kastritis, Dimitrios Christoulas, Magdalini Migkou, Maria Gavriatopoulou, Flora Zagouri, Evangelos Terpos
Journal: Blood (2008)
Comprehensive in Vitro and in Vivo Analysis of Phosphatidylinositol-3-Kinase Delta (PI3Kδ) Inhibition Using GS-1101 (CAL-101) in Combination with Mammalian Target of Rapamycin (mTOR) Inhibition Using Temsirolimus or Everolimus in Mantle Cell Lymphoma (MCL)
Authors: Paul M. Barr, Francisco J. Hernandez-Ilizaliturri, Thomas Murante, Shannon P. Hilchey, Derick R Peterson, Jennifer L. Kelly, Dave M. Johnson, Brian J. Lannutti, Myron S. Czuczman, Jonathan W. Friedberg, Steven H. Bernstein
Journal: Blood (2012)
Drug Resistance Gene Therapy by Simultaneous Lentiviral Overexpression of MDR1 in Combination with the MGMT P140K Mutant in Human Hematopoietic Stem Cells.
Authors: Isabel Spier, Patrick Maier, Stephanie Laufs, Marlon R. Veldwijk, Frederik Wenz, W. Jens Zeller, Stefan Fruehauf
Journal: Blood (2007)
Angiotensin-I Converting Enzyme Inhibitors and the Survival of Patients with Multiple Myeloma Treated by Autologous Stem Cell Transplantation.
Authors: Tomas Buchler, Marta Krejci, Adam Svobodnik, Zdenek Adam, Jiri Minarik, Jaroslav Bacovsky, Vlastimil Scudla, Jiri Mayer, Jiri Vorlicek, Roman Hajek
Journal: Blood (2004)
Allogeneic Transplantation with a Treosulfan-Fludarabine Conditioning Regimen Is Feasible and Effective in Elderly Patients with Refractory or Relapsed Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndrome (MDS); Preliminary Results From a Single Center Experience.
Authors: Massimo Bernardi, Jacopo Peccatori, Michela Tassara, Alessandro Crotta, Carlo Messina, Maria Teresa Lupo Stanghellini, Barbara Forno, Stefania Girlanda, Andrea Assanelli, Daniela Clerici, Sara Mastaglio, Annalisa Ruggeri, Simona Malato, Fabio Giglio, Consuelo Corti, Elena Guggiari, Matteo Giovanni Carrabba, Chiara Bonini, Fabio Ciceri
Journal: Blood (2009)
Comparative Studies on the HIT Antibody Mediated Platelet Aggregation / Serotonin Release by Synthetic Pentasaccharide and Two Chemoenzymatically Synthesized Heptasaccharides
Authors: Jeanine M. Walenga, Chris Aranda, Robert Linhardt, Jian Liu, Mary Lewis, Debra Hoppensteadt, Jawed Fareed
Journal: Blood (2011)
Investigations of Glucocorticoid Action in GN
Authors: Christoph Kuppe, Claudia van Roeyen, Katja Leuchtle, Nazanin Kabgani, Michael Vogt, Marc Van Zandvoort, Bart Smeets, Jürgen Floege, Hermann-Josef Gröne, Marcus J. Moeller
Journal: Journal of the American Society of Nephrology (2016)

For several decades, glucocorticoids have been used empirically to treat rapid progressive GN. It is commonly assumed that glucocorticoids act primarily by dampening the immune response, but the mechanisms remain incompletely understood. In this study, we inactivated the glucocorticoid receptor (GR) specifically in kidney epithelial cells using Pax8-Cre/GRfl/fl mice. Pax8-Cre/GRfl/fl mice did not exhibit an overt spontaneous phenotype. In mice treated with nephrotoxic serum to induce crescentic nephritis (rapidly progressive GN), this genetic inactivation of the GR in kidney epithelial cells exerted renal benefits, including inhibition of albuminuria and cellular crescent formation, similar to the renal benefits observed with high-dose prednisolone in control mice. However, genetic inactivation of the GR in kidney epithelial cells did not induce the immunosuppressive effects observed with prednisolone. In vitro, prednisolone and the pharmacologic GR antagonist mifepristone each acted directly on primary cultures of parietal epithelial cells, inhibiting cellular outgrowth and proliferation. In wild-type mice, pharmacologic treatment with the GR antagonist mifepristone also attenuated disease as effectively as high-dose prednisolone without the systemic immunosuppressive effects. Collectively, these data show that glucocorticoids act directly on activated glomerular parietal epithelial cells in crescentic nephritis. Furthermore, we identified a novel therapeutic approach in crescentic nephritis, that of glucocorticoid antagonism, which was at least as effective as high-dose prednisolone with potentially fewer adverse effects.
<scp>d</scp>-Cycloserine, an NMDA Glutamate Receptor Glycine Site Partial Agonist, Induces Acute Increases in Brain Glutamate Plus Glutamine and GABA Comparable to Ketamine
Authors: Joshua T. Kantrowitz, Matthew S. Milak, Xiangling Mao, Dikoma C. Shungu, J. John Mann
Journal: American Journal of Psychiatry (2016)
Risk Factors for Donor-Type Aplasia after Bone Marrow Transplant in Children with Acquired Bone Marrow Failure
Authors: Asahito Hama, Hideki Muramatsu, Atsushi Narita, Hironobu Kitazawa, Motoharu Hamada, Shinsuke Kataoka, Norihiro Murakami, Daisuke Ichikawa, Rieko Taniguchi, Daiei Kojima, Kyogo Suzuki, Eri Nishikawa, Yusuke Okuno, Nozomu Kawashima, Nobuhiro Nishio, Masafumi Ito, Seiji Kojima, Yoshiyuki Takahashi
Journal: Blood (2012)
Kinetic of Iron Absorption and Expression of Iron Related Genes in Beta-Thalassemia.
Authors: Laura Breda, Sara Gardenghi, Ella Guy, Ninette Amariglio, Konstantin Adamsky, Orly Weizer-Stern, Eliezer Rachmilewitz, Gideon Rechavi, Patricia J. Giardina, Robert W. Grady, Stefano Rivella
Journal: Blood (2005)
Clinical Characteristics and Outcomes of Patients with Hodgkin Lymphoma with Central Nervous System Involvement: An International Multicenter Collaboration
Authors: Chan Yoon Cheah, Paul J Broeckelmann, Alison J Moskowitz, Andreas Engert, Mats Jerkeman, Tarec Christoffer El-Galaly, Julie Vose, Diego Villa, Joseph M. Connors, Tatyana Feldman, Dai Chihara, Chelsea C Pinnix, Sarah A Milgrom, Bouthaina S. Dabaja, Yasuhiro Oki, Michelle A. Fanale
Journal: Blood (2015)
Mutations in the Fms-Related Tyrosine Kinase 3 (FLT3) Gene Independently Predict Poor Outcome in Acute Myeloid Leukemia (AML) with t(8;21): A Study of the German-Austrian AML Study Group (AMLSG).
Authors: Peter Paschka, Juan Du, Richard F. Schlenk, Lars Bullinger, Verena I. Gaidzik, Andrea Corbacioglu, Axel Benner, Manuela Zucknick, Frank Stegelmann, Daniela Späth, Sabine Kayser, Brigitte Schlegelberger, Juergen Krauter, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood (2009)
Study on the Relevance of Inducing Apoptosis and Reversal Effect of Nilotinib In Combination with Tet on Multidrug Reststahoe of K562/A02 Cell Line
Authors: Bao-An Chen, Ting-yun Cui, Jia-hua Ding, Chong Gao, Xue-yun Shan, Jian Cheng, Wen Bao, Yue-jiao Zhong, Feng Gao, Guo-hua Xia, Anita Schmitt, Michael Schmitt
Journal: Blood (2010)
A call to strengthen the global strategy against schistosomiasis and soil-transmitted helminthiasis: the time is now
Authors: Nathan C Lo, David G Addiss, Peter J Hotez, Charles H King, J Russell Stothard, Darin S Evans, Daniel G Colley, William Lin, Jean T Coulibaly, Amaya L Bustinduy, Giovanna Raso, Eran Bendavid, Isaac I Bogoch, Alan Fenwick, Lorenzo Savioli, David Molyneux, Jürg Utzinger, Jason R Andrews
Journal: The Lancet Infectious Diseases (2016)
An integrated platform for the discovery and confirmation of protein urinary biomarkers for bladder cancer in a carcinogen induced rat model.
Authors: R.R. Townsend, H. Rohrs, R. Leduc, Y. Yi, R. Yao, J. Malone, P. Erdman-Gilmore, C. Grubbs, M. You, R. Lubet
Journal: Cancer Research (2008)

AACR Annual Meeting-- Apr 12-16, 2008; San Diego, CA

LB-294 

Proteomics were employed to measure proteins expressed in the urines of female Fischer-344 rats. Urines were collected from rats bearing large (>200 mg) bladder tumors induced by 4-hydroxybutyl(butyl)nitrosamine and from non-carcinogen treated rats (n=10/group). Within the past 2 years, rapid acquisition, high-resolution mass spectrometry and associated statistical-based data analysis tools have become available. We have used a biomarker discovery-confirmation platform that consists of optimized, reproducible sample preparation methods for urinary proteins, robust nano-LC hybrid (linear quadrupole (LTQ) Fourier transform ion cyclotron or LTQ-orbitrap mass spectrometers) mass spectrometry, and a bioinformatics pipeline using vendor and novel software. Using a new sample preparation protocol, peptides were prepared from the urine samples. The peptide pools were analyzed using nano-LC-LTQ-FT-MS. The twenty LC-MS analyses were aligned and the integrated accurate mass signals were quantified using Rosetta ElucidatorTM software. Comparison of the urines from the normal and tumor bearing rats showed that 3,032 of 15,557 peptides changed by > 3-fold. To determine if candidate markers from previous cDNA micro-array (433 transcripts, > 3-fold) and proteomic (160 unique proteins, > 3-fold) experiments from similar tumors were present in these urines, our integrated data pipeline was used to perform in silico tryptic digestion of transcripts and proteins. Peptide mass fingerprinting was then performed using the accurate mass values (+/- 5 ppm) from the LC-MS analyses. The tentative protein identifications that were significantly increased in the urines of tumor-bearing rats were confirmed by targeted tandem mass spectrometry. It was found that annexins (1,2 and 7), S100 proteins (4, 6 and 11), calpactin, and galectin were increased at least 1000-fold. These urinary biomarkers should prove useful both in identifying tumor bearing animals and in determining the efficacy of preventive or therapeutic modalities.
Current Technical Issues for Surgery of Primary Liver Cancer
Authors: Yoshikuni Kawaguchi, Goro Honda, Itaru Endo, Daniel Cherqui, Norihiro Kokudo
Journal: Liver Cancer (2016)

Primary liver cancer is the fifth most common cancer worldwide. Apart from liver transplantation, surgical resection has been accepted as the effective local treatment for hepatocellular carcinoma (HCC), one of the most common primary liver cancers. Recent technological innovations including navigation technology and intraoperative real-time fluorescence guidance have been utilized for liver resections in clinical practice. With respect to liver resection techniques, the laparoscopic approach has been increasingly gaining popularity as one of the minimally-invasive treatments of HCC. These technological innovations and technical advancements are expected to further improve the safety and efficacy of liver resections.
Glucose Transporter 3 in Platelets Facilitates Alpha-Granule Mediated Glucose Uptake, Driving Intragranular Glycolysis That Is Required for Platelet Degranulation and Activation
Authors: Fidler P.L Trevor, Elizabeth Middleton, Jesse W Rowley, Luc Boudreau, Robert A. Campbell, Rhonda Souvenir, Eric Boilard, E. Dale Abel, Andrew S. Weyrich
Journal: Blood (2015)
Reimagining the Initial Office Visit
Authors: Christine T. Bozlak
Journal: JAMA Oncology (2016)

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The Oncogenic Kinase Bcr-Abl Directly Regulates Splicing of BclX through a Quaternary Complex Coordinated by Nck-Beta and Sam-68 Adapter Proteins.
Authors: Bracco Enrico, Valentina Rosso, Mussino Stefano, Francesca Arruga, Sonia Carturan, Francesca Messa, Cristina Panuzzo, Marco Lo Iacono, Paolo Nicoli, Emanuela Messa, Antonia Rotolo, Monica Pradotto, Alessandro Morotti, Alessandra Balbo, Ilaria Iacobucci, Giovanni Martinelli, Daniela Cilloni, Giuseppe Saglio
Journal: Blood (2009)
Virus Specific T-Lymphocytes Genetically Modified to Target the CD19 Antigen Eradicates Systemic Lymphoma In Mice
Authors: Kevin J. Curran, Clare Taylor, Ekaterina Doubrovina, Xiuyan Wang, Richard J. O'Reilly, Michel Sadelain, Nancy A. Kernan, Renier J. Brentjens, Isabelle Riviere
Journal: Blood (2010)
Differential Impact of Host Derived Interleukin-18 on Regulatory and Conventional T Cell Expansion Following Murine Allogeneic Hematopoietic Cell Transplantation.
Authors: Robert Zeiser, Elizabeth A. Zambricki, Dennis B. Leveson-Gower, Andreas Beilhack, Neeraja Kambham, Robert S. Negrin
Journal: Blood (2007)
MicroRNA-Mediated Translation Repression of PRDM1 in Hodgkin/Reed-Sternberg Cells - A Potential Pathogenetic Lesion in Hodgkin Lymphoma.
Authors: Kui Nie, Mario F. Gomez, Pablo Landgraf, Jose-Francisco Garcia, Yifang Liu, Leonard H.C. Tan, Amy Chadburn, Thomas Tuschl, Daniel M. Knowles, Wayne Tam
Journal: Blood (2006)
Revisiting Hypogammaglobulinemia in Chronic Lymphocytic Leukemia: A Combined Clinicobiological Approach
Authors: Panagiotis Baliakas, Aliki Xochelli, Eva Minga, Anastasia Hadzidimitriou, Vassiliki Douka, George Karavalakis, Ioanna Chouvarda, Nikolaos Maglaveras, Chrysoula Belessi, Kostas Stamatopoulos, Niki Stavroyianni, Achilles Anagnostopoulos
Journal: Blood (2014)
Coping with self management
Authors: Ceinwen Giles
Journal: BMJ (2016)

What patients really need is a “health PA,” says Ceinwen Giles 

Patient activation, self management, shared decision making . . . all of these sound great. I would be very happy to self manage—if I could figure out how.

Seven years ago I was diagnosed with stage 4 diffuse large B cell lymphoma. Chemotherapy pushed the disease into remission but it also left me with long term side effects, one of which is a poorly functioning immune system. I can just about manage the immunoglobulin infusions, blood tests, flu jabs, and infections—but if you add anything else into the mix my carefully self managed house of cards collapses.

Last summer, for example, I developed an unusual patch of skin on my leg. Years ago I had something similar and it turned out to be from an autoimmune condition. “Isn’t it strange,” I said to my immunology nurse, “that someone with a weak immune system would also develop an autoimmune condition?” Quite frankly I was a …
Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia
Authors: Michael R. Grever, Omar Abdel-Wahab, Leslie A. Andritsos, Versha Banerji, Jacqueline Barrientos, James S. Blachly, Timothy G. Call, Daniel Catovsky, Claire Dearden, Judit Demeter, Monica Else, Francesco Forconi, Alessandro Gozzetti, Anthony D. Ho, James B. Johnston, Jeffrey Jones, Gunnar Juliusson, Eric Kraut, Robert J. Kreitman, Loree Larratt, Francesco Lauria, Gerard Lozanski, Emili Montserrat, Sameer A. Parikh, Jae H. Park, Aaron Polliack, Graeme R. Quest, Kanti R. Rai, Farhad Ravandi, Tadeusz Robak, Alan Saven, John F. Seymour, Tamar Tadmor, Martin S. Tallman, Constantine Tam, Enrico Tiacci, Xavier Troussard, Clive S. Zent, Thorsten Zenz, Pier Luigi Zinzani, Brunangelo Falini
Journal: Blood (2016)
Infectious Complications Among Individuals with Monoclonal B-Cell Lymphocytosis (MBL): A Prospective Case-Control Study of Newly Diagnosed Patients,
Authors: Jonathan Moreira, Kari Rabe, James R Cerhan, Curtis A. Hanson, Timothy G Call, Clive S. Zent, Jose F. Leis, Deborah A. Bowen, John Wilson, Neil Kay, Susan Schwager, Randy F Wendt, Susan L Slager, Tait D. Shanafelt
Journal: Blood (2011)
Improving the Quality of Our Clinical Work for Coumadin Anticoagulation Therapy with Electronic Medical Record (EMR) Based System Redesign
Authors: Linda Thomas-Hemak, Lisa Thomas, Qi Shi, Jignesh Sheth, Etikala Praveen, Gunjan Choudhary, Cherif Abdelmalek, Vijayadershan Muppidi, Tiffany Eikins
Journal: Blood (2012)
The Cytokine Signal Inhibitor Lnk Promotes αIIbβ3 Integrin Outside-In Signaling through β3 Tyrosine Phosphorylation in Platelets.
Authors: Koji Eto, Hitoshi Takizawa, Satoshi Takaki, Hidekazu Nishikii, Atsushi Oda, Hiromitsu Nakauchi
Journal: Blood (2007)
Statistical Approaches for Assessing Health Effects of Environmental Chemical Mixtures in Epidemiology: Lessons from an Innovative Workshop
Authors: Kyla W. Taylor, Bonnie R. Joubert, Joe M. Braun, Caroline Dilworth, Chris Gennings, Russ Hauser, Jerry J. Heindel, Cynthia V. Rider, Thomas F. Webster, Danielle J. Carlin
Journal: Environmental Health Perspectives (2016)

Summary:Quantifying the impact of exposure to environmental chemical mixtures is important for identifying risk factors for diseases and developing more targeted public health interventions. The National Institute of Environmental Health Sciences (NIEHS) held a workshop in July 2015 to address the need to develop novel statistical approaches for multi-pollutant epidemiology studies. The primary objective of the workshop was to identify and compare different statistical approaches and methods for analyzing complex chemical mixtures data in both simulated and real-world data sets. At the workshop, participants compared approaches and results and speculated as to why they may have differed. Several themes emerged: a) no one statistical approach appeared to outperform the others, b) many methods included some form of variable reduction or summation of the data before statistical analysis, c) the statistical approach should be selected based upon a specific hypothesis or scientific question, and d) related mixtures data should be shared among researchers to more comprehensively and accurately address methodological questions and statistical approaches. Future efforts should continue to design and optimize statistical approaches to address questions about chemical mixtures in epidemiological studies.
Functional CXCR4 Expressing Microparticles and SDF-1 Correlate with Circulating AML Cell Counts.
Authors: Alexander Kalinkovich, Sigal Tavor, Abraham Avigdor, Joy Kahn, Alexander Brill, Isabelle Petit, Polina Goichberg, Melania Tesio, Neta Netzer, Elizabeth Naparstek, Izhar Hardan, Arnon Nagler, Igor Resnick, Alexander Tsimanis, Tsvee Lapidot
Journal: Blood (2006)
FLT3 Inhibitor Treatment in FLT3-Mutated AML Is Associated with Development of Secondary FLT3-TKD Mutations
Authors: Yesid Alvarado, Hagop M. Kantarjian, Farhad Ravandi, Rajyalakshmi Luthra, Gautam Borthakur, Guillermo Garcia Manero, Stefan Faderl, Marina Konopleva, Zeev Estrov, Michael Andreeff, Jorge E. Cortes
Journal: Blood (2011)
Myeloid Progenitors Protect Against Radiation-Induced Intestinal Injury.
Authors: Janice (Wes) Brown, Sumana Shashidhar, Aida Habtezion, Stacy M. Burns-Guydish, Sophia Y. Wang, Jos Domen, Tim Fong, Christopher H. Contag, M. Bishr Omary
Journal: Blood (2005)
Tumor Necrosis Factor Alpha Inhibits Telomerase and Induces Senescence in Acute Myeloid Leukemia Cells.
Authors: Odile Beyne-Rauzy, Christian Recher, Nicole Dastugue, Nais Prade-Houdellier, Geraldine Pottier, Cecile Demur, Laure Sabatier, Guy Laurent, Veronique Mansat-DeMas
Journal: Blood (2004)
Pharmocokinetic (PK)-Directed High Dose Intravenous Busulfan, Cyclophosphamide and Etoposide Produces Predictable Drug Exposure and Durable Long Term Survival In Lymphoma Patients Undergoing Autologous Stem Cell Transplantation
Authors: Hongzheng Zhang, Michael Graiser, Donald Hutcherson, M. Olufemi Dada, Stephanie McMillan, Ali Zahir, Christopher R Flowers, Edmund Waller
Journal: Blood (2010)
Phase I Study to Assess the Safety and Tolerability of AZD1152 In Combination with Low Dose Cytosine Arabinoside In Patients with Acute Myeloid Leukemia (AML)
Authors: Hagop M. Kantarjian, Mikkael A. Sekeres, Vincent Ribrag, Philippe Rousselot, Guillermo Garcia-Manero, Elias Jabbour, Kate Owen, Paul Stockman, Stuart Oliver
Journal: Blood (2010)