tbuckley/cabot-search huggingface dataset:
Behavioral change in African American breast cancer survivors: results and challenges.
Authors: RF Young, D Zora, D Deutsch-Keahey
Journal: Cancer Research (2009)

Abstract Abstract #1126 Background: African American breast cancer survivors have higher cancer mortality and greater prevalence of health risk behaviors than Caucasians. They are appropriate candidates for a behavioral intervention but few lifestyle change studies focus exclusively on this population.&amp;#x2028; Methods: 37 breast cancer survivors enrolled in a healthy living study that sought to implement a comprehensive lifestyle and breast care intervention to an African American target population. The 12-month intervention included behavioral change classes and individualized telephone counseling. Questionnaires and anthropometric measurement determined diet, exercise, cancer history and care, and psychosocial characteristics (quality of life on FACT-G; breast cancer and obesity awareness; self-efficacy). At entry subjects averaged: 60 yrs. Of age; 7 yrs. Post-breast cancer diagnosis; 190 lbs. Body weight; BMI = 32; 5.1 fruit/vegetable servings daily; 48% diagnosed at cancer stage I; 33% calories from fat in diet.&amp;#x2028; Results: 68% completed the 12-month study. Subjects who attended &amp;lt;2 of 8 class sessions had higher BMI at intake (p &amp;lt; .05). Oldest subjects were less likely to complete the study (p &amp;lt;.05). Behavioral changes at 4-months (after 8 classes) were: +3.5 hrs. weekly exercise; -2.37 % fat in diet; - 1 lb. weight. 12-month outcomes (after telephone counseling) were: average weight loss 1.44 lbs; small reduction in BMI; rise in moderate or more physical activity; improved cancer and obesity awareness; improved FACT-G scores (p = .07); reduced self efficacy for behavioral change (p &amp;lt; .05) as subjects realized the implications of improving eating and exercise habits. Neither length of time since cancer diagnosis nor age effected the extent of behavioral change.&amp;#x2028; Discussion: African American breast cancer survivors entered, and many completed, a intensive health behavior intervention. Overall, study completers improved their exercise behavior, food choices, and lost a modest amount of weight. Some early changes (4 months) were sustained over 12 months. Subjects with higher BMIs at entry provided the most challenge; they attended fewer class sessions and were less likely to lose weight. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1126.
Abstract 242: Analyses of novel genes encoding secreted and transmembrane proteins identified by CAST method: CDON is highly expressed in prostate cancer
Authors: Hayashi Tetsutaro, Naohide Oue, Katsuhiro Anami, Naoya Sakamotro, Kazuhiro Sentani, Shinya Ohara, Jun Teishima, Akio Matsubara, Wataru Yasui
Journal: Cancer Research (2010)

Abstract Prostate cancer (PCa) is one of the most common human cancers. Identification of novel genes that encode membrane-spanning or secreted proteins expressed specifically in PCa has a great advantage to develop of ideal biomarkers for cancer diagnosis and therapeutics. Escherichia coli Ampicillin Secretion Trap (CAST) is a signal sequence trap method to identify genes encoding cell surface and secreted proteins. In this study, to identify novel diagnostic and therapeutic targets of PCa, CAST method was used. We generated cDNA libraries from normal prostate and two PCa cell lines, LNCaP and DU145. These CAST libraries were ligated into the pCAST which was plasmid with a mutant beta-lactamase lacking the endogenous signal peptide. Survival on ampicillin was observed only when various cDNA fragments encoding a signal sequence were inserted. We sequenced 960 ampicillin-resistant colonies for normal prostate CAST library, 1344 colonies for LNCaP CAST library and 960 colonies for DU145 CAST library. By comparing these sequences to those deposited in the public databases using BLAST (NCBI), 223 genes from normal prostate CAST library, 234 genes from LNCaP and 228 genes from DU145 were identified. To extract highly expressed genes in PCa, the genes expressed in normal prostate were excluded. Quantitative RT-PCR analyses of 64 candidate genes were performed and compared mRNA levels in 9 PCa tissues, 2 normal prostate tissues and 14 kinds of normal tissues. Quantitative RT-PCR analyses revealed that CDON was highly expressed in PCa. Overexpression of CDON (tumor/normal ratio &amp;gt; 2) was observed in 8 (89%) of 9 PCa tissues. CDON is a cell surface receptor of the immunoglobulin /fibronectin type III repeat family. By western blot analysis, low to moderate CDON expression was noted in LNCaP cell extracts and moderate to high CDON expression was noted in DU145 cell extracts. The expression of CDON in LNCaP and DU145 was suppressed by treatment with CDON specific siRNA. Cell invasion assay and MTT assay revealed that knockdown of CDON in LNCaP cells did not inhibit both cell growth and invasion ability, but knockdown of CDON in DU145 cells inhibited both cell growth and invasion ability. In conculusion, CAST is a robust and rapid method to identify cell surface and secreted proteins. CDON was up-regulated in PCa and participated in cell growth and invasion. These finding suggest that CDON may be a good therapeutic target. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 242.
FRI0506 Total Joint Arthroplasty in Dermatomyositis and Polymyositis: Table 1.
Authors: S.M. Goodman, S.J. DiMartino, W.-T. Huang, M.P. Figgie, C.N. Cornell, L.A. Mandl
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Little is known about total joint arthroplasty (TJA) in dermatomyositis (DM) and polymyositis (PM), although patients are at risk for osteonecrosis from corticosteroid use. <h3>Objectives</h3> To describe total knee (TKA) and total hip (THA) arthroplasty in DM/PM. <h3>Methods</h3> We identified 8 patients with DM/PM enrolled in an institutional arthroplasty registry between 2007 and 2011. The diagnosis was validated with medical record review. Self-report, physical therapy, and administrative data were collected. These patients were compared with a convenience sample of gender-matched osteoarthritis controls undergoing similar procedures. Outcomes were evaluated through 1/2014. <h3>Results</h3> 8 patients underwent 11 procedures during the study period: 5 patients had 5 TKA and 3 patients had 6 THA. 1 patient met Bohan criteria for definite DM/PM, 5 probable, and 2 possible. Patients with DM/PM had poorer post-operative progress with physical therapy, particularly in activities where proximal strength was important. DM/PM patients were less likely to climb stairs by the day of discharge (p-value=0.002) and were 2x less likely to achieve pre-determined physical therapy goals (p-value=0.01). There was no difference in level distance walked (17.3 ft vs. 23.08, p-value=0.87). Osteonecrosis was present in 7 joints. Post-op, 2 TKA patients required manipulations, and 1 required revision for pain and poor function at 39 months. 1 THA patient who had both hips replaced underwent revision for a prosthetic joint infection at 5 months and a subsequent contralateral THA revision for recurrent dislocation at 41 months. For OA, there was 1 manipulation and 1 revision. No patients had any cardio-pulmonary complications prior to discharge. 2 DM/PM patients with 2-year self-report data showed similar pain and function as the OA controls. <h3>Conclusions</h3> In this small cohort of DM/PM patients, 25% of prosthesis was revised within 3.5 years. DM/PM patients appear slower to meet post-operative rehabilitation goals than OA patients. Whether this is due to proximal muscle weakness is not known. Although not usually proscribed, this may be a unique patient group in which pre-operative muscle strengthening is indicated. Although limited by the retrospective study design and missing data, to our knowledge this is the only known report on the outcomes of TJA in DM/PM. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2165
FRI0502 Osteoporosis and Fracture Risk in Outpatients with Systemic Sclerosis
Authors: S. Breda, F. Inverardi, V. Codullo, L. Bogliolo, F. De Nard, G. Cagnotto, R. Caporali, C. Montecucco
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Osteoporosis (OP) is a frequent complication of a number of chronic inflammatory diseases. Only Rheumatoid Arthritis (RA) is included in the FRAX algorythm to calculate fracture risk but also Systemic Sclerosis (SSc) displays many disease-specific OP risk factors (chronic inflammation, malnutrition, steroid use, etc.) <h3>Objectives</h3> To determine OP frequency and fracture risk by FRAX in outpatients with SSc <h3>Methods</h3> After consent, in outpatients with SSc (le Roy criteria) of a University Hospital, bone mineral density (BMD) was calculated by Dual Energy X-Ray Absorptiometry (DEXA) at the femoral neck and lumbar spine and FRAX was obtained by the calculation tool (http://www.shef.ac.uk/FRAX). A routine SSc evaluation (according to EUSTAR) was performed as well. Age- and BMI-matched early AR (ACR/EULAR 2010 criteria) patients and healthy controls (HC) were enrolled as well. <h3>Results</h3> Seventy-one SSc patients (3:68 M:F, age 66±9yrs, 57:14 limited:diffuse cutaneous, median disease duration 8.5, 2.4-14.7yrs, median disease activity 1, 0.25-2), 44 AR (11:33 M:F, age 62±12yrs, median DAS28 4.42, 3.94-5) and 29 healthy controls (all F, 60.1±10.7yrs) were enrolled. OP was detected in 42/71 (59%) SSc patients. Disease duration was significantly higher in SSc-OP patients (10.5, 4.3-16.6 vs 5.5, 1.6-9.8, p&lt;0.01) and it was also significantly associated to OP (OR 1.4, 1.1-1.7, p&lt;0.01), even when corrected at a multivariable analysis for other disease-specific features (skin and gastrointestinal involvement, autoantibody subset, median mRSS, disease activity) and OP risk factors (steroid use, smoke, BMI, chronic renal insufficiency). OP in RA patients was significantly lower than in SSc (9/44, 20%, p&lt;0.001). Mean femoral BMD was 0.58 (0.53-0.7) in SSc vs 0.72 (0.64-0.82) in RA and 0.7 (0.51-0.75) in HC (p&lt;0.0001), lumbar mean BMD 0.82 (0.75-0.9) in SSc vs 0.92 (0.81-1) in RA and 0.89 (0.67-0.99) in hc (p=NS). FRAX for major fracture was not significantly different between disease groups (low in 47% and 50%, medium in 28% and 40%, high in 25% and 10% of SSc and RA respectively) while it was significantly different for SSc vs HC (p&lt;0.001) and for AR vs HC (p&lt;0.01). A diagnosis of SSc was significantly associated to OP (OR=13.2, 4-42.4), even when corrected for steroid use. <h3>Conclusions</h3> We have detected a very high OP frequency in our SSc patients, significantly higher than a control early AR cohort and significantly associated to disease duration. Routine DEXA evaluation and risk factors for OP should always be considered and treated when possible in every SSc patient, especially after 5 years of disease duration. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5172
ALL-CAUSE MORTALITY BENEFIT IN PATIENTS UNDERGOING MITRAL VALVE SURGERY WITH CORONARY ARTERY BYPASS AS COMPARED TO ISOLATED CORONARY ARTERY BYPASS SURGERY IN PATIENTS WITH MODERATE ISCHEMIC MITRAL REGURGITATION: A META-ANALYSIS
Authors: Hafeez Hassan, Saurav Chatterjee, Mohammed Ahmed, Byomesh Tripathi, Eyal Herzog, Angela Palazzo, Chirag Bavishi, Jay Giri, Robert Kornberg
Journal: Journal of the American College of Cardiology (2016)
AB0753 Potential of cardio-thoracic ratio measured on chest radiography for the prediction of pulmonary hypertension: correlation with pulmonary arterial systolic pressure estimated by echocardiography
Authors: S. Y. Lee, S. W. Lee, W. T. Chung, J. H. Bae
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Currently, there are no data on the association between pulmonary hypertension and chest radiography changes specific for idiopathic pulmonary arterial hypertension in lupus. Therefore, we aimed to assessthe correlation of cardio-thoracic (CT) ratiomeasured by chest radiography for predicting pulmonary hypertension estimated by echocardiography in lupus patients. <h3>Objectives</h3> This study aims to determine whether CT ratio is increased in lupus patients with pulmonary hypertesion and its correlation with disease activity and other parameters. <h3>Methods</h3> 105 patients (median 42.75±2.14 years; 10 male) who had undergone chest radiography and echocardiography were divided into two groups (hypertensive and normotensive) based upon an echocardiography-derived pulmonary arterial systolic pressure (PASP) of 25 mmHg. CT ratio was measured twice. 1<sup>st</sup> CT ratio was calculated at the time of enrolled trial and 2<sup>nd</sup> CT ratio was calculated after two years later. Difference between 1<sup>st</sup> and 2<sup>nd</sup> measured CT ratio, 1<sup>st</sup> CT ratio and 2<sup>nd</sup> CT ratio were then correlated with PASP using regression analysis. The Area Under the Curve (AUC) for predicting pulmonary hypertension on CT ratio was calculated. <h3>Results</h3> In the pulmonary hypertensive group, the mean PASP was 53.13±7.76 mmHg (39-104 mmHg) and there was statistical strong correlation between the increased 2<sup>nd</sup> cardiothoracic ratios and PASP (OR=0.228 p=0.002) but, not correlation with 1<sup>st</sup> cardiothoracic ratio (OR=-0.055 p=0.462) and difference between 1<sup>st</sup> and 2<sup>nd</sup> CT ratio (OR=0.044 p=0.472). Interstitial lung disease in lupus patients were associated with PASP (OR=0.277 p=0.002) statistically. The intraobserver and interobserver correlation coefficients for cardiothoracic ratios were 0.990 and 0.892. The AUC for predicting pulmonary hypertension over 25 mmHg by echocardiography was 0.668 in 1<sup>st</sup> CT ratio (P&gt;0.05), 0.918 in 2<sup>nd</sup> CT ratio and 0.919 in difference between 1<sup>st</sup> and 2<sup>nd</sup> CT ratio (P&lt;0.05). <h3>Conclusions</h3> Increased CT ratios of chest radiography was correlated statistically well with PASP estimated by echocardiography and could be used to predict pulmonary hypertension over 25 mmHg with high sensitivity and specificity. <h3>Acknowledgements</h3> Pulmonary hypertension in systemic sclerosis and systemic lupus erythematosus. S.R. Johnson, J.T. Granton, Eur Respir Rev 2011; 20: 122, 277–286. <h3>Disclosure of Interest</h3> None Declared
A8.7 Differentiation of human TH17 cells
Authors: Eszter Baricza, Barbara Molnár-Érsek, Edit Buzás, György Nagy
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background and Objectives</h3> Th17 cells represent a subset of T helper lymphocytes that produces several inflammatory cytokines, including interleukin-17A, -17F, -21, -22, and tumor necrosis factor. Increased Th17 cell differentiation and IL-17 production have been observed in rheumatoid arthritis (RA) and in several other autoimmune diseases. IL-17 contributes to development of inflammation and promotes osteoclast differentiation in RA. We have studied the differentiation of Th17 cells. <h3>Materials and Methods</h3> CD4 positive T cells were negatively separated by magnetic method from peripheral blood mononuclear cells (PBMC) of healthy volunteers. The cells were treated for 5-10 days with anti-CD3 and anti-CD28 antibodies and with TGFβ (2.5ng/ml), IL-6 (25ng/ml) and IL-1 (10ng/ml) cytokines, furthermore with anti-IL-4 (10μg/ml) and anti-IFNγ (10μg/ml) blocking antibodies. The IL-17 and IL-22 production was measured by ELISPOT and ELISA, the RORγt expression was measured by real-time PCR and by Western blot methods, cell viability was monitored by Trypan blue staining and by Annexin V binding. <h3>Results</h3> Anti-CD3/CD28 treatment increased the IL-17 production, but did not alter the RORγt expression. The anti-CD3/CD28, TGFβ, IL-6, and IL-1 induced RORγt expression was further increased by the anti-IL-4 and anti-IFNγ antibody treatment. Anti-CD3/CD28-induced IL-22 production was inhibited by TGFβ, IL-6, IL-1, anti-IL-4 and anti-IFNγ antibody treatment. The applied treatments did not change the viability of the cells. <h3>Conclusion</h3> Our present results suggest that IL-17 and IL-22 production are differentially regulated during CD4 T cell activation and Th17 differentiation.
Real-Time Sharing of Zika Virus Data in an Interconnected World
Authors: Esper G. Kallas, David H. O’Connor
Journal: JAMA Pediatrics (2016)

Zika virus is new to the Americas and is spreading through populations with no preexisting immunity.Physicians astutely noted a correlation between the emergence of Zika virus and the appearance of birth defects in babies 1,2 and neurologic complications in otherwise immunocompetent adults. 3The rapid accumulation of knowledge about Zika virus less than 1 year after the first description of Zika virus circulation in Brazil 4 is a testament to the endeavor of the global scientific community, including researchers from affected countries. 5 The contrast between the early response to Zika virus and human immunodeficiency virus (HIV)/AIDS is notable.Some involved in the initial response to HIV/ AIDS lament that more was not done "when the epidemic was most vulnerable to intervention-the moment it was first reported." 6The first case reports were published in 1981, the virus was discovered in 1983, and the first official mention from the Reagan administration did not occur until 1986. 6In contrast to the slow recognition of HIV/AIDS as a global concern, worldwide interest in Zika virus soared in early 2016, 7 fueled at least in part by information sharing on social media platforms that did not exist 35 years ago. 8But are scientists who are entrusted with the responsibility to inform the public health response to Zika virus taking full advantage of the same technologies?Are we sharing data as
A Controlled Trial of Artemether or Quinine in Vietnamese Adults with Severe Falciparum Malaria
Authors: Tran Tinh Hien, Nicholas P.J. Day, Nguyen Hoan Phu, Nguyen Thi Hoang Mai, Tran Thi Hong Chau, Pham Phu Loc, Dinh Xuan Sinh, Ly Van Chuong, Ha Vinh, Deborah Waller, Timothy E.A. Peto, Nicholas J. White
Journal: New England Journal of Medicine (1996)

Artemisinin (qinghaosu) and its derivatives are rapidly effective antimalarial drugs derived from a Chinese plant. Preliminary studies suggest that these drugs may be more effective than quinine in the treatment of severe malaria. We studied artemether in Vietnam, where Plasmodium falciparum has reduced sensitivity to quinine.
Autosomal recessive limbgirdle muscular dystrophy, LGMD2F, is caused by a mutation in the δ–sarcoglycan gene
Authors: Vincenzo Nigro, Eloisa de Sá Moreira, Giulio Piluso, Mariz Vainzof, Angela Belsito, Luisa Politano, Annibale A. Puca, Maria Rita Passos-Bueno, Mayana Zatz
Journal: Nature Genetics (1996)
The usefulness of EUS elastography in the diagnosis of upper gastrointestinal submucosal tumor
Authors: Kai Xu, Ping Xu, Da-bin Ren, Jing Wang, Hai-bin Yu
Journal: Endoscopy (2011)

Objective: To explore the EUS elastographic pattern of upper gastrointestinal submucosal tumor (SMT), and the potential usefulness of EUS elatography for the benign and malignant determination. Methods: Between January 2009 and May 2010, a total of 24 patients (14 males, 10 females, mean age 57.1 years) who received EUS examination in our department because of SMT were enrolled. The locations of lesion were 8 cases in esophagus, 13 cases in stomach and 3 cases in duodenum. The sizes of lesion ranged from 0.6 to 7.1cm, with an average of 2.42cm. Real-time elastography was carried out during the conventional EUS examination. Compression was naturally obtained by arterial pulsations and respiratory movements. The relative stiffness of tissue was described by colors superimposed on the B-mode image: hard tissue areas were marked with blue, intermediate areas with green, medium soft areas with yellow and soft areas with red. The final diagnosis was based on the histopathology of specimen resected by surgery or endoscopy. Results: Elastography was successfully performed in all patients. We classified elastographic patterns into four different types based on the color composition of SMT's elastographic image: type I was assigned when the image showed a homogenous green area; type II was a mixture with green, yellow, and red; type III was heterogeneous color mixed with blue, green, yellow and red; type IV was heterogeneous pattern with blue dominated mixed color. The correspondence between histopathology and elastographic pattern is shown in table 1. The results demonstrats that elatographic pattern of benign SMT and low risk GIST tends to be type I, II and III. On the other hand, all moderate/high risk GIST shows an elatographic pattern of type IV. Furthermore, the lesion mainly displays type I and II pattern when smaller than 2cm. When larger than 2cm, type III and IV become the most common pattern. This may be explained by the commonly appearance of liquefaction and necrosis in larger lesion. Unlike pancreatic lesion, there was no homogenous blue pattern appearing in SMT. Conclusions: There are apparent differences in elastographic pattern between benign SMT, low risk GIST and moderate/high risk GIST. EUS Elastography may provide a potential role in the benign and malignant determination of SMT.
EVOLUCIÓN ENDOSCÓPICA DE LESIONES GASTROINTESTINALES TRAS RADIOEMBOLIZACIÓN HEPÁTICA CON MICROESFERAS DE 90Y
Authors: I Rodríguez Lago, C Carretero Ribón, MT Betés Ibáñez, MT Herráiz Bayod, B Sangro Gómez-Acebo, M Muñoz-Navas
Journal: Endoscopy (2011)

Introducción: El hepatocarcinoma constituye el sexto tumor más frecuente a nivel mundial. La radioembolización hepática con microesferas cargadas con 90Y (90Y -RE) es una terapia relativamente nueva usada para el tratamiento del hepatocarcinoma y las metástasis hepáticas tanto de cáncer colorrectal como de tumores neuroendocrinos. La embolización extrahepática con las microsferas es un efecto adverso descrito aunque poco frecuente. Se han publicado casos de colecistitis, pancreatitis, neumonitis y úlceras esofágicas, gástricas y duodenales. No hay datos publicados sobre la evolución clínica o endoscópica de las lesiones a largo plazo.
COMPARISON OF CLINICAL OUTCOMES AFTER TRANSRADIAL AND TRANSFEMORAL INTERVENTIONS IN CONTEMPORARY ANTIPLATELET ERA: A PROPENSITY SCORE-MATCHED ANALYSIS
Authors: Jeong Cheon Choi, Kwang Soo Cha, Jong Hyun Choi, Bo Won Kim, Jin Sup Park, Hye Won Lee, Jun-Hyok Oh, Jung Hyun Choi, Han Cheol Lee, Taek Jong Hong, Young Jin Youn, Seung Hwan Lee, Junghan Yoon, Kyoo Rok Han, Sang Sig Cheong, Byung Ryul Cho, Jang-Ho Bae, Seung-Woon Rha, Yun-Hyeong Cho, Jin-Bae Lee, Hee-Yeol Kim, John Seo Seo, Min Su Hyon, Jae Woong Choi, Keun-Soo Park, Myung Ho Jeong, Sang Wook Kim, Jae-Hwan Lee, Sung Ho Her, Kyung-Soo Kim, Doo-Il Kim
Journal: Journal of the American College of Cardiology (2015)