tbuckley/cabot-search huggingface dataset:
AB0381 Clinical and Ultrasound Assessment of Thyroid in Rheumatoid Arthritis Mexican Patients
Authors: P.J. Pérez Cruz, E. Gόmez-Bañuelos, J.E. Aguilar-Arreola, A. Saldaña Millán, M. Figueroa-Sánchez, H. Macías-Reyes, R.E. Navarro-Hernández, M. Vazquez-Del Mercado
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> There is scarce information about the usefulness of ultrasound and biopsy of the thyroid gland in rheumatoid arthritis (RA) patients with thyroid nodules classified as TIRADS 4 (Thyroid Imaging Reporting and Data System). In this study, we also described the prevalence of thyroid dysfunction and autoimmune thyroid disease in a cohort of RA patients without comorbidities. The purpose of this study was to support the clinical utility of thyroid gland screening in RA. <h3>Methods</h3> We included 78 RA patients and 81 healthy controls (HC) classified by thyroid function. All of them underwent thyroid ultrasound and anti-thyroid antibodies screening. Subjects with TIRADS ≥4 were subjected to fine needle aspiration biopsy (FNAB). Continuous variables were analyzed with Student t test. Categorical variables were evaluated with c<sup>2</sup> test or Fisher exact test. Correlations between variables were tested with Pearson r coefficient. <h3>Results</h3> We found hypothyroidism in 24.4% <i>vs.</i> 1.2% in RA compared to HC (<i>P</i>=0.003). Of these, 89.5% were classified as subclinical hypothyroidism and 10.5% as overt hypothyroidism. In hypothyroid <i>vs.</i> euthyroid RA patients, we found higher titers of anti-TPOAb (310.38±633.73 <i>vs</i> 31.26±27.13, <i>P</i>=0.01) and anti-TGAb (417.85±1052.51 <i>vs</i> 18.40±19.17, <i>P</i>=0.02). According to TIRADS classification, we found a statistical difference <i>vs</i> HC, being the most common TIRADS 1 in both groups, follow by 2,3,4a and 4b. FNAB was performed in 7 RA patients and 1 HC, all of them reported as autoimmune thyroiditis. <h3>Conclusions</h3> The clinical and US assessment of the thyroid gland in RA patients showed that the TIRADS classification has to be interpreted with a different context applied for the general population, since, despite the risk of malignancy that implies TIRADS 4 category, all of our cases were classified with autoimmune thyroiditis. The most common functional thyroid status was subclinical hypothyroidism and not development of anti-thyroid antibodies. Further studies are needed to evaluate the utility of imaging, immunological and functional status of thyroid gland in RA <h3>Disclosure of Interest</h3> None declared
Studies on an Ascites (Reticuloendothelial Cell?) Sarcoma of the Rat&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn3"&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/xref&gt;
Authors: Yoshida, Tomizo
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Studies on an Ascites (Reticuloendothelial Cell?) Sarcoma of the Rat Get access Tomizo Yoshida Tomizo Yoshida Department of Pathology, Tohoku University Medical School, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 5, April 1952, Pages 947–969, https://doi.org/10.1093/jnci/12.5.947 Published: 01 April 1952 Article history Received: 24 September 1951 Published: 01 April 1952
Is painting the earliest portrayal of Down's syndrome?
Authors: Roger Dobson
Journal: BMJ (2003)

Psychiatrists have identified what is believed to be one of the earliest paintings of someone with Down's syndrome.



The 1515 Flemish painting (detail right), by an unknown artist, considerably predates John Langdon Down's first description of the condition in 1866. It shows an angel (next to Mary) and possibly one other figure, …
Prognostic/predictive biomarkers in advanced soft tissue sarcomas (STS): Translational research associated to randomized phase II trial comparing trabectedin-doxorubicin versus doxorubicin—A GEIS study.
Authors: Javier Martin Broto, Jorge Martinez-Serra, Rafael Ramos, Jose Antonio Lopez-Guerrero, Silvia Bague, Carmen Martinez, Ramiro Alvarez, Xavier Garcia del Muro, Ramon De Las Penas, Antonio Gutierrez, Javier Martinez-Trufero, Josefina Cruz, Andres Poveda, Rosa Maria Alvarez, Ricardo Cubedo, Andrés Redondo, Juan Maurel, María Ángeles Sala, Jose A. Lopez-Martin, Antonio Lopez-Pousa
Journal: Journal of Clinical Oncology (2014)

10500 Background: Nucleotide excision and homologous recombination DNA repair pathways are the most recognized antitumor mechanism of action of trabectedin in STS. Additionally, our group has shown the relevance of FAS and calcium signaling pathways in the efficacy of trabectedin in preclinical experiments with sarcoma cell lines. Thus, in vein with that, a prospective translational research focusing on DNA repair genes, calcium and FAS signaling pathways was designed accompanying a randomized phase II trial in STS. The trial comparing trabectedin-doxorubicin (TD) vs doxorubicin (D) as first line of advanced or metastatic STS patients was stopped for futility after enrolling 115 patients. Methods: Immunohistochemistry studies were performed for FASR, Bcl2, p53, PKC-α and PKC-β and for RNA expression FASR, FASL, CUL4A, ERCC1 and ERCC5 were analyzed. Kaplan–Meier estimations were used for time-to-event variables and the log-rank test was used to compare groups. Results: With a median follow-up of 11 months, there were 95 events of recurrences and 63 of deaths. Regarding the entire series, p53+ had significant lower PFS (1.33m vs 6.53m, p= 0.002) and FASR+ showed a significant better OS (21.07m vs 8.33m, p= 0.002). Remarkably, combining FASR/p53 showed to be a strong prognostic factor for PFS (7.03m if FASR+ and p53-, 2.93m if FASR+ or p53 – and 0.50m if FASR- and p53 +; p < 0.001) and OS (26.9m if FASR+ and p53-, 13.5m if FASR+ or p53- and 4.5m if FASR- and p53 +; p=0.001). In TD arm, the following biomarkers showed significant better PFS: FASR+ (6.5m vs 2.9m; p= 0.033); p53- (6.53 m vs 1.33 m; p=0.02); CUL4A above median (8.1 m vs 1.7m; p= 0.015) and ERCC1 above median (8.23 m vs 2.93, p= 0.031). Those with a significant better OS were: FASR+ (21.07m vs 5.9 m; p=0.033) and CUL4A above median (21.83m vs 9.43m; p=0.041). In D arm no significant association was seen Conclusions: FASR and p53 have shown to be strong prognostic factors in advanced/metastatic STS while CUL4A seemed highly predictive to trabectedin. These biomarkers should be taken into account in future trials design focusing on this population of STS. Clinical trial information: NCT01104298.
Study of Environmental Factors in Cancer of the Respiratory Tract in Cuba&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Ernest L. Wynder, M.D., Antonio Navarrete, M.D., Gonzalo E. Arostegui, M.D., Juan L. Llambes, M.D.
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Study of Environmental Factors in Cancer of the Respiratory Tract in Cuba Get access Ernest L. Wynder, M.D., Ernest L. Wynder, M.D. Section of Epidemiology, Division of Preventive Medicine, Sloan-Kettering Institute, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Antonio Navarrete, M.D., Antonio Navarrete, M.D. Section of Epidemiology, Division of Preventive Medicine, Sloan-Kettering Institute, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Gonzalo E. Arostegui, M.D., Gonzalo E. Arostegui, M.D. Section of Epidemiology, Division of Preventive Medicine, Sloan-Kettering Institute, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Juan L. Llambes, M.D. Juan L. Llambes, M.D. Section of Epidemiology, Division of Preventive Medicine, Sloan-Kettering Institute, New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 4, April 1958, Pages 665–673, https://doi.org/10.1093/jnci/20.4.665 Published: 01 April 1958 Article history Received: 07 August 1957 Published: 01 April 1958
PWE-085 Analysis of new patient attendances for nafld at three london hospitals highlights the need to develop clinical risk stratification pathways
Authors: A Srivastava, R Gailer, S Gulati, A Warner, S Morgan, K Sennett, D Suri, D Thorburn, E Tsochatzis, W Rosenberg
Journal: Gut (2015)

<h3>Introduction</h3> 30% of the UK population has NAFLD. A significant minority (10%) will have NASH of whom 15% will develop cirrhosis. Recognising this subpopulation at risk can be difficult as patients are often asymptomatic. Non-invasive tests (NIT) of liver fibrosis including FIB4 and the Enhanced Liver Fibrosis (ELF) panel have been validated in NAFLD and provide opportunities to devise risk stratification pathways. We reviewed GP referrals with a final diagnosis of NAFLD to three London hospitals to assess the potential role of NIT in new pathways. <h3>Method</h3> All new GP referrals to the Royal Free, Whittington and University College London hospitals with a final diagnosis of NAFLD between 1/4/12 and 31/3/13 had their electronic records assessed. Demographic, clinical, laboratory and outcome data were collected. The potential impact of the use of FIB4 was evaluated. Prospectively FIB4 and ELF are being used to stratify patients prior to referral. <h3>Results</h3> Over 1 year, 191 patients with a final diagnosis of NAFLD were referred by GP’s. 130 had sufficient data to calculate FIB-4 values. 87 patients (67%) had FIB4 &lt;1.30 (low risk of advanced liver disease) and no liver related events were documented. 3 patients [2%] had FIB4 &gt;3.25 (high risk of advanced liver disease). FIB4 was indeterminate (1.30–3.25) in 40 (31%) who would be stratified with ELF in the new pathway (Figure 1). Twenty (15%) had a liver biopsy. 10 (8%) had FIB4 &lt;1.30, each of whom had a histological stage of ≤F2 fibrosis and could have avoided referral under the new pathway. Of 7 (5%) with confirmed cirrhosis on biopsy, two had FIB4 &gt;3.25 and 5 had indeterminate FIB4 scores (1.30–3.25). <h3>Conclusion</h3> New approaches to tackle the increasing burden of NAFLD are required. Patients at low risk of advanced fibrosis should have their risk factors managed in primary care, whilst those at high risk need specialist input. Existing methods are ineffective in stratifying patients. Applying FIB4, 67% of referrals could have been avoided but the majority of cirrhotic patients would not have been identified. We have initiated a novel primary care pathway integrating the use of FIB4 and ELF (to categorise FIB-4 indeterminate cases) to stratify patients for management in primary or secondary care. Within the 1st year, over 400 patients have entered the pathway and data from clinical and cost effectiveness analysis are due in mid 2015. <h3>Disclosure of interest</h3> None Declared.
Videoendoscopy in Clinical Application
Authors: D L Carr-Locke
Journal: Endoscopy (1990)

The introduction of videoendoscopy has had a revolutionary impact on endoscopy teaching on a small scale within the Endoscopy unit itself and on a larger scale in the Conference Room which may be local or distant. The teaching of anatomy, pathology and endoscopic techniques have all been significantly affected and further improvements in electronic peripherals may make further image manipulation possible with further applications in teaching.
A case of petit-mal status: a diagnostic dilemma
Authors: M P Weissberg
Journal: American Journal of Psychiatry (1975)

The author describes a case in which the "crazy" behavior of a woman with petit mal status (PMS) was initially misinterpreted in an emergency room situation. The diagnosis of PMS was confirmed by electroencephalography. The author notes the need to consider the possibility of this diagnosis when there is a history of seizures in conjunction with an altered state of consciousness.
New Approaches to the Evaluation of the Metastatic Ability of Renal Cancer and New Approaches to Chemotherapy
Authors: William B. Isaacs, John T. Isaacs, Natasha Kyprianou, John K. Burgers, Richard B. Alexander, Alan W. Partin, James L. Mohler, Fray F. Marshall, Donald S. Coffey
Journal: European Urology (1990)
Basic Surveillance Network, a European database for surveillance data on infectious diseases
Authors: A Ternhag, A Tegnell, B Lesko, K Skaerlund, P Penttinen
Journal: Eurosurveillance (2004)

The Basic Surveillance Network was started in 2000 and is one of the networks on infectious diseases funded by the European Commission. The network collects and makes readily available basic surveillance data on infectious diseases from all the 'old' (pre-2004) European Union member states. The aim is to provide easy access to descriptive data that already exist in national databases, so that it is possible to monitor and compare incidence trends for infectious diseases in the EU member states. The list of diseases covered by the network has recently been expanded from 10 initial 'pilot' diseases to over 40 diseases listed by the EU to be under surveillance. In the near future, the new member states will be invited to participate in the network. Data are case-based and comprise date of onset of disease, age and sex. Only a very short list of disease specific additional variables, such as country of infection or immunisation status, is collected. Classification of cases ( possible, probable, confirmed) is specified according to EU case definitions. The participants of the network have access to an internal web site were all the data is presented in tables and graphs. An open website is available for the public at https://www.eubsn.org./BSN/
Extent of Nonspecific Background Localization of Radioiodinated Serum Proteins in Human Tumor and Normal Tissues
Authors: Eugene D. Day, Ahsen Özarda
Journal: JNCI Journal of the National Cancer Institute (1959)

The 24-hour uptake of intravenously injected, radioiodinated, rabbit- and human-serum globulins and human-serum albumin, in a variety of human tumor and normal tissues, was measured after surgical excision. No detectable difference between the uptake by tumor and normal tissue was found. An average background localization value of 0.004 percent (normalized to a 50-kg. patient) of the injected radioactive dose per gm. of wet, unperfused tissue was obtained. It was concluded that in any future assays of whole radioiodinated antitumor antiserum globulin, tumor-localizing antibodies of average titer, if and when obtained, should be detectable in human tumors, above and beyond the nonspecific background localization of radioiodinated serum proteins, without purification and concentration.
PTU-147 A retrospective audit of 30 day mortality outcome in patients referred and assessed as unsuitable for percutaneous gastrostomy
Authors: A Dhaliwal, J Colby, N Burch
Journal: Gut (2015)

<h3>Introduction</h3> Percutaneous gastrostomy insertion is a common procedure performed for a route of enteral nutrition. There are a number of studies observing outcomes in patients in whom PEG is performed. We carried out an audit to review patients who are referred for PEG, assessed as unsuitable, and observed their outcome. <h3>Method</h3> We retrospectively identified patients who were directly referred for PEG assessment and deemed unsuitable for PEG placement via our electronic nutrition team referral system from March 2013 –February 2014. Outcomes of all referrals were recorded electronically. There were a total of 103 patients (n = 103; female 51, male 52, average age 74 years (age range 29–97 years)). We analysed the following parameters: referral to review time, reasons for unsuitability, 30 day mortality outcome, total mortality outcome including inpatient vs discharge, by 21 months follow up. <h3>Results</h3> 87% of patients had a ward review by the nutrition team. The remaining 13% were discussed via telephone. 93% patients were reviewed within 7 days, 55% patients within 72 h. The most frequent cause for unsuitability remained palliation (26%) or improvement in oral intake such that PEG was no longer required (22%). Other factors included patients who were clinically unstable and unwell for PEG insertion (10%), deterioration (11%), and anatomical factors. 30 day mortality was 38% (39 /103). Of these patients, 82% (32) died in hospital with 18% (7) discharged. 29 of in hospital death patients had a mortality review by our follow up period. The majority 39% (14) died of pneumonia, mostly commonly aspiration pneumonia. A further 22 patients (37%) deteriorated over 30 days with overall total mortality of 59% (61/103). 36 patients (35%) in total died within hospital during the referral admission or subsequent admission 5 patients (5%) died on the day of or prior to review. 17% patients died within 2 weeks of review by the nutrition team. 41% patients survived at 21 month follow up, who had improved or at risk oral intake or enteral nutrition. <h3>Conclusion</h3> Our results show that there is a high 30 day and total mortality rate, in our cohort unsuitable for PEG insertion suggesting that our assessment of such patients is appropriate given their mortality would be significantly increased if they had undergone PEG insertion. This highlights the importance of appropriate clinical assessment and patient selection when considering suitability for PEG insertion. 17% of patients died within 2 weeks highlighting the number of patients inappropriately referred to the Nutrition Team for consideration of PEG and perhaps raises the need for greater education of allied medical specialities in understanding the risk of PEG placement and factors to consider when identifying patients who may benefit from PEG placement. <h3>Disclosure of interest</h3> None Declared.
Screening for gestational diabetes mellitus
Authors: Ned Calonge, Diana B. Petitti, Thomas G. DeWitt, Leon Gordis, Kimberly D. Gregory, Russell Harris, George Isham, Michael L. LeFevre, Carol Loveland-Cherry, Lucy N. Marion, Virginia A. Moyer, Judith K. Ockene, George F. Sawaya, Albert L. Siu, Steven M. Teutsch, Barbara P. Yawn, US Preventive Serv Task Force
Journal: Annals of Internal Medicine (2003)
Treatment of Regional Lymph Nodes in Breast Cancer—Evidence in Favor of Radiation Therapy
Authors: Philip M. P. Poortmans, Charlotte Coles, Jacques Bernier
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
AB1040 The Value of Ultrasonography in the Evaluation of Hand Gouty Arthritis – A Comparison with Conventional Radiography
Authors: A.E. Musetescu, C. Criveanu, F. Vreju, M. Florea, A. Bumbea, A. Rosu, P. Ciurea
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Gout represents a frequent inflammatory rheumatic disease affecting peripheral joints with an increasing prevalence in our country. Musculoskeletal ultrasound is an emerging tool of increasing interest able to detect both structural and inflammatory lesions and facilitate disease diagnosis and monitoring. <h3>Objectives</h3> To demonstrate, assess and quantify the pathological findings associated with chronic gout in the second metacarpophalangeal (MCP) joint through musculoskeletal ultrasound in comparison with conventional radiography. <h3>Methods</h3> We evaluated 24 patients previously diagnosed with chronic gout and at least one episode of hand arthritis. Ultrasound evaluation was performed by a trained rheumatologist unaware of the clinical data using a Prosound α7 equipment with a multifrequency linear probe and using the standardized scanning technique. The following pathological findings were recorded on ultrasound: cortical erosions defined as breaks in the cortical contour of metacarpal head or proximal phalanx, seen in two perpendicular planes, tophaceous deposits defined as hyperechoic crystalline concrements and calcified tophi defined as hyperechoic aggregates with posterior acustic shadow. Conventional radiographs of anteroposterior and lateral view of the hand were assessed by a trained rheumatologist in the absence of the clinical and ultrasonographic data considering as pathological findings suggestive for gout. Both methods evaluated in a qualitative manner the abnormal findings (presence or absence) <h3>Results</h3> We assessed 24 patients (21 males, 3 females) with a total number of 48 MCP joints evaluated. Compared to conventional radiography musculoskeletal ultrasound detected significantly more erosions (p&lt;0.001). Erosions were detected in 23/48 joints (47.9%) compared to only 5/48 joints (10.4%) through conventional radiography. In addition to structural lesions ultrasound was able to detect inflammatory changes associated with gout. Intra-articular tophaceous deposits were detected in 39/48 joints (81.2%) using ultrasound while conventional radiography could not detect un-calcified tophaceous material. Intra-articular calcification of the tophaceous material was seen in 3/48 joints (6.2%) using ultrasound and in 2/48 joints (4.16%) using conventional radiography. <h3>Conclusions</h3> Musculoskeletal ultrasound is an extremely valuable tool in the evaluation of gouty arthritis of the hand identifying a significantly higher number of erosions compared to radiographic evaluation as well as in visualizing the intra-articular tophaceous deposits. While uncalcified tophaceous deposits are missed by the conventional radiologic evaluation, calcified tophi are seen by both imaging methods. <h3>Disclosure of Interest</h3> None declared
Anti-Myeloma Activity by the Combination of the JAK2 Inhibitor Ruxolitinib with Lenalidomide and Corticosteroids
Authors: Haiming Chen, Eric Sanchez, Mingjie Li, Cathy Wang, Abby Gillespie, Anna Shvartsur, Suzie Vardanyan, Nika M Harutyunyan, Gigi Garzio, George Tang, Benjamin Bonavida, James R. Berenson
Journal: Blood (2014)
Geropsychiatric consultation in a university hospital: a report on 67 referrals
Authors: P E Ruskin
Journal: American Journal of Psychiatry (1985)

The author describes the evaluation and treatment of 67 patients 60 years old or older who were referred to a consultation-liaison service in a university hospital. Age, sex, referring service, reasons for referral, psychiatric diagnosis, and interventions or recommendations were determined. Primary psychiatric diagnoses included depression (24%), dementia (19%), delirium (18%), schizophrenia (16%), and personality disorders (12%). Recommendations or interventions included advice in the use of psychotropic medications (61%), assistance with competency issues (25%), recommendation for further medical evaluation or treatment (36%), individual psychotherapy (28%), family therapy (25%), disposition planning (24%), and transfer to a geropsychiatry unit (12%). Hospitalized elderly patients with emotional problems represent a unique diagnostic and therapeutic challenge.