tbuckley/cabot-search huggingface dataset:
STEM-14CELLULAR RESTING TRANSMEMBRANE POTENTIAL INSTRUCTS DIFFERENTIATION STATE OF GBM STEM-LIKE CELLS
Authors: Brian Williams, Suchitra Joshi, Edward Oldfield, Emmanuel Petricoin, Jaideep Kapur, Deric Park
Journal: Neuro-Oncology (2015)

INTRODUCTION: Glioblastoma (GBM) is the most common malignant brain tumor in adults with a poor prognosis despite maximal treatment. Resting membrane potential (RMP) has been shown to be an important regulator of the differentiation state of embryonic and somatic stem cells. We evaluated the relevance of RMP in GBM stem-like cells (GSC). METHODS: Whole cell patch clamp technique was used to determine the RMP. RESULTS: Undifferentiated GSC had a RMP of -5mV +/-4 (n = 33) compared to their differentiated counterparts, which had a mean RMP of -24mV +/-20 (n = 31, P < 0.001). To determine whether the cellular RMP played an instructive role in the differentiation state of GSC we used pharmacologic and genetic approaches to alter the potential. We added additional potassium chloride (KCl) to differentiated GCS in order to induce depolarization, and compared to osmotic controls using sodium chloride (NaCl). We found that GSC exposed to high KCl retained stem markers and sphere forming capacity compared to controls. We then examined whether hyperpolarization was sufficient to induce differentiation. We treated GSC with vacuolar ATPase inhibitors and salinomycin (potassium ionophore), which induced relative hyperpolarization of GSC and induction of differentiation. Transduction of GSC with inducible potassium ion channel led to hyperpolarization and differentiation. To identify potential mechanisms coupling electrical alterations to biochemical signal transduction pathways we performed extensive phospho-protein array studies comparing the undifferentiated GSC and cells hyperpolarized with omeprazole or salinomycin. Attenuation of key developmental and pro-growth signaling pathways was observed. CONCLUSIONS: Alteration of RMP may represent a new therapeutic strategy.
Clinical and Serologic Interleukin 2 Receptor α Response to Interleukin-2 in CCG-2961, a Ranomized Phase 3 Trial for Pediatric Acute Myeloid Leukemia.
Authors: Beverly Lange, Richard K Yang, Jacek Gan, Jaqueline A Hank, Eric Sievers, Robert Gerbing, Todd Alonzo, Paul M Sondel
Journal: Blood (2008)
Autologous bone marrow transplantation for first remission acute myeloblastic leukemia in patients older than 50 years: a retrospective analysis of the European Bone Marrow Transplant Group
Authors: JY Cahn, M Labopin, F Mandelli, AH Goldstone, K Eberhardt, J Reiffers, A Ferrant, I Franklin, P Herve, A Gratwohl
Journal: Blood (1995)
Group and individual as complementary conceptual categories
Authors: Hart Blanton
Journal: Behavioral and Brain Sciences (2016)

Abstract Baumeister et al. depart from self-theories that contrast the psychology of the group with the psychology of the individual by considering how differentiated identities further collective interests. In concert with Deviance Regulation Theory, their framework offers a foundation for predicting the reward and punishment contingencies that will help groups function as more than the sum of their parts.
Real-time real-world analysis of seasonal influenza vaccine effectiveness: method development and assessment of a population-based cohort in Stockholm County, Sweden, seasons 2011/12 to 2014/15
Authors: Amy Leval, Maria Pia Hergens, Karin Persson, Åke Örtqvist
Journal: Eurosurveillance (2016)

Real-world estimates of seasonal influenza vaccine effectiveness (VE) are important for early detection of vaccine failure. We developed a method for evaluating real-time in-season vaccine effectiveness (IVE) and overall seasonal VE. In a retrospective, register-based, cohort study including all two million individuals in Stockholm County, Sweden, during the influenza seasons from 2011/12 to 2014/15, vaccination status was obtained from Stockholm's vaccine register. Main outcomes were hospitalisation or primary care visits for influenza (International Classification of Disease (ICD)-10 codes J09-J11). VE was assessed using Cox multivariate stratified and non-stratified analyses adjusting for age, sex, socioeconomic status, comorbidities and previous influenza vaccinations. Stratified analyses showed moderate VE in prevention of influenza hospitalisations among chronically ill adults ≥ 65 years in two of four seasons, and lower but still significant VE in one season; 53% (95% confidence interval (CI): 33-67) in 2012/13, 55% (95% CI: 25-73) in 2013/14 and 18% (95% CI: 3-31) in 2014/15. In conclusion, seasonal influenza vaccination was associated with substantial reductions in influenza-specific hospitalisation, particularly in adults ≥ 65 years with underlying chronic conditions. With the use of population-based patient register data on influenza-specific outcomes it will be possible to obtain real-time estimates of seasonal influenza VE.
Blocking Stat3 to Regulate the Balance of Th17/Treg in Cgvhd Therapy
Authors: Jianyu Weng, Xin Huang, Xiaomei Chen, Qiong Luo, Jianhua Su, Jiaqi Tong, Zhi Cao, Peilong Lai, Suijing Wu, Chengwei Luo, Wei Ling, Xin Du
Journal: Blood (2015)
International Standardized Approach to Molecular and Flow Cytometric Residual Disease Monitoring in CLL.
Authors: A. C. Rawstron, N. Villamor, J. L. Zehnder, P. Ghia, M. Ritgen, S. Bottcher, G. Lozanski, A. P. Mone, D. Colomer, C. Moreno, M. Geuna, P. A. Evans, M. Kneba, Y. Natkunam, S. E. Coutre, F. Caligaris-Cappio, M. J. Hallek, J. C. Byrd, E. Montserrat, P. Hillmen
Journal: Blood (2004)
First-in-Human Clinical Trials — What We Can Learn from Tragic Failures
Authors: Sergio Bonini, Guido Rasi
Journal: New England Journal of Medicine (2016)

On January 10, 2016, a healthy volunteer who had received 50 mg per day of a fatty acid amide hydrolase (FAAH) inhibitor for 5 days as part of a first-in-human phase 1 clinical trial was admitted to Rennes University Hospital with neurologic and gait disturbances. After a dramatic worsening of neurologic symptoms, the participant died on January 17. Another 5 participants who received the same drug dose for 6 days were subsequently admitted to the hospital, 4 of them with similar neurologic symptoms. In this issue of the Journal, Kerbrat et al.1 report the clinical and imaging findings of the . . .
WHO launches global guidelines to stop surgical site infections
Authors: Anne Gulland
Journal: BMJ (2016)

Patients should not be shaved before surgery and should get antibiotics only before and during surgery, not afterwards, the World Health Organization has said.1

The advice is part of WHO’s first ever global guidelines on reducing surgical site infections (SSIs), a list of 29 recommendations to prevent infection before, during, and after surgery. They complement the surgical safety checklist launched by WHO in 2009.2

Ed Kelley, director of WHO’s department of service delivery and …
Efficacy Trial In An Acute Liver Trauma Animal Model Of Novel Infusible Hemostatic Product: Red Blood Cell-Derived Microparticles (RMP)
Authors: Wenche Jy, Max E Johansen, Carlos Bidot, Rifat Pamukcu, Orlando Gomez-Marin, Eugene Ahn, Lawrence L Horstman, Yeon S Ahn
Journal: Blood (2013)
We need more humanity as well as better evidence
Authors: Kamran Abbasi
Journal: BMJ (2016)

Is it possible to improve health, improve care, and save money? You might consider this an impossible calculus from a baseline of austerity, but that is the challenge set for the NHS’s 44 sustainability and transformation plans. The draft plans are already causing friction at a time when there is enough friction in the system already (doi:10.1136/bmj.i5898).

Take general practice, for example. New models of working promise an end to small practices, more integrated care, and the …
MLL-Associated Leukemias Drive Expression of MiR-9, Required for Tumorigenesis
Authors: Colles Price, Ping Chen, Zejuan Li, Yuanyuan Li, Anissa Wiley, Chunjiang He, Rejani B. Kunjamma, Hao Huang, Xi Jiang, Stephen Arnovitz, Mary Beth Neilly, Janet D. Rowley, Jianjun Chen
Journal: Blood (2012)
THE POWERS <sup>TM</sup> STRAP MODIFIES HIP AND KNEE MOVEMENT DURING THE SINGLE LEG SQUAT AND THE SINGLE LEG STEP DOWN TASK
Authors: H Greuel, RK Jones, L Herrington, L Anmin
Journal: British Journal of Sports Medicine (2016)

Previous research has shown that excessive hip internal rotation can lead to abnormal patellar maltracking and thereby to lower limb injuries, such as patellofemoral pain and non-contact ACL injuries. Researchers in the USA invented the Powers TM strap to increase external rotation of the femur and to thereby stabilise the patellofemoral joint during leisure and sport activities. This study aimed to investigate whether the PowersTM strap influences knee and hip biomechanics during the single leg squat (SLS) and step down task (SDT), which are activities which involve excessive hip internal rotation, adduction and knee valgus. 17 healthy participants, 7 males and 10 females (age: 29±4 y, height: 1.72±0.07 m, mass: 65.4±8.7 kg) were required to perform the single leg squat and step down tasks during two conditions: without and with the Powers TM strap. Three-dimensional analysis was conducted with ten Qualisys OQUS7 cameras and three AMTI force plates using a 6DoF biomechanical model. The normality was assessed using the Shapiro-Wilk test. Paired sample t-tests were performed at the 95% confidence interval. The Powers TM strap condition (red line) reduced hip internal rotation and knee internal rotation during the SLS (hip IR: p=0.000, knee IR: p=0.007) and the step down task (hip IR: p=0.000, knee IR: p=0.003). In addition, the Powers TM strap increased the hip internal rotation moment (p=0.000) and knee adducting moment (p=0.000) during the SLS task. The Powers TM strap decreased hip and knee internal rotation, decreased the knee valgus and increased the hip internal rotation moment as well as knee adducting moment. These results suggest that the Powers TM strap might have a strong potential to improve abnormal hip motion during leisure activities and sports in patients with lower limb injuries. Thus, the Powers TM strap should be further tested in subjects who suffer from lower limb malalignment to investigate the full potential of it and to enable an implementation for therapeutic use in future.
Beclin-1 Phosphorylation By BCR-ABL Is Crucial for CML Leukemogenesis By Suppression of Autophagy
Authors: Chuanjiang Yu, Sivahari Prasad Gorantla, Tony Mueller, Lena Lippert, Zhenyu Yue, Robert Zeiser, Tobias Huber, Justus Duyster, Anna Lena Illert
Journal: Blood (2015)
Treatment of Carotid Intramural Thrombus With TPA
Authors: Alicia Bennett, Jana Wold, Adam de Havenon
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Modeling the Effects of Priming With the Whole-Cell Bordetella Pertussis Vaccine—Reply
Authors: Haedi DeAngelis, Samuel V. Scarpino, Benjamin M. Althouse
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
MEPs call for legal limits on trans fats
Authors: Rory Watson
Journal: BMJ (2016)

The EU is coming under increasing pressure to pass legislation limiting the use of trans fats (TFAs) in food.

The European Parliament has called on the European Commission to present draft legislation within two years. This should be accompanied by an assessment of the costs that a limit might have on the food industry, and the possibility that these might be passed on to consumers.

Renate Sommer, a German Christian Democrat MEP and one of the politicians behind the move, said: “Excessive …
Graft Versus Leukemia (GVL) Effect in the Central Nervous System Sanctuary: Successful Treatment with Donor Lymphocyte Infusion (DLI) in a Patient with Resistant Ph1+ Acute Lymphoblastic Leukemia.
Authors: Mauricio Ostronoff, Mariana Coutinho Domingues, Fabiana Ostronoff, Rodolfo Calixto, Ana Patricia Souto, Alexandre Sucupira, Rodrigo Florêncio, Kleber Matias, Clemente Tagliari
Journal: Blood (2005)
Effect of Transfusion of the Third Party Umbilical Cord Blood on Haplo-Identical Hematopoietic Stem Cell Transplantation
Authors: Jing Bo Wang, Xin Hong Fei, Hao Yu Cheng, Yu Ming Yin, Wei Jie Zhang, Shu Qin Zhang, Qian Li, Song Xue, Jiang Ying Gu, Jun Bao He, Fan Yang, Meng Qi Liu, Jie Zhao, Dai-Hong Liu
Journal: Blood (2015)
PP2A plays a key role in inflammation and cancer through tristetraprolin activation
Authors: Ion Cristóbal, Blanca Torrejón, Juan Madoz-Gúrpide, Federico Rojo, Jesús García-Foncillas
Journal: Annals of the Rheumatic Diseases (2016)

We have read with great interest the recent work by Ross et al ,1 which provides novel relevant findings about the therapeutic efficacy of using protein phosphatase 2A (PP2A)-activating drugs to target tristetraprolin (TTP) in rheumatoid arthritis (RA). In this elegant work, the authors showed that TTP is overexpressed and colocalises with activated mitogen-activated protein kinase (MAPK) p38 in RA synovial tissue. MAPK p38 phosphorylates and inhibits TTP at two serine residues, and Ross et al determined that these phosphorylation sites are critical for …
Sequential Combination of Azacitidine and Lenalidomide Can Target the TP53-Mutated Clone in Del(5q) Higher-Risk Myelodysplastic Syndromes
Authors: Uwe Platzbecker, Friederike Braulke, Andrea Kuendgen, Katharina S. Götze, Gesine Bug, Katayoon Shirneshan, Christoph Röllig, Martin Bornhäuser, Ralph Naumann, Jürgen Neesen, Aristoteles Giagounidis, Wolf-Karsten Hofmann, Gerhard Ehninger, Ulrich Germing, Detlef Haase, Martin Wermke
Journal: Blood (2012)
Analysis of Let-7a and Mir-17-5p Micro-RNAs Expression In Patients with Adult De Novo Myelodysplastic Syndromes
Authors: D. Vassilatou, Vassiliki Pappa, F. Kontsioti, S. Papageorgiou, C. Kontos, P. Tsirigotis, C. Economopoulou, E. Ioannidou, E. Papageorgiou, Ioannis Dervenoulas
Journal: Blood (2010)
Factor XI Homodimer Formation Is Mediated by Electrostatic (Lys331 with Glu287) and Hydrophobic (Ile290 with Leu284 and Tyr329 with Tyr329) Interactions in the Apple 4 Domain and Is Essential for Normal Proteolytic Activation of Factor XI by Factor XIIa, Thrombin and Factor XIa.
Authors: Wenman Wu, Dipali Sinha, James D. Lear, Paul C. Billings, Peter N. Walsh
Journal: Blood (2007)
Effectively Targeting Treatment-Naïve CML Stem/Progenitor Cells From Imatinib-Nonresponders With Combination Treatments Of JAK2 and ABL Inhibitors In Vitro and In Vivo
Authors: Hanyang Lin, Min Chen, Katharina Rothe, Matthew V Lorenzi, Adrian Woolfson, Xiaoyan Jiang
Journal: Blood (2013)
ATPS-25p53 STATUS DEPENDENCE OF TUMOR TREATING FIELDS (TTFIELDS) EFFICACY AGAINST GLIOMA CANCER CELLS
Authors: Rosa S. Schneiderman, Tali Voloshin, Moshe Giladi, Yaara Porat, Mijal Munster, Roni Blat, Shay Sherbo, Eilon D. Kirson, Uri Weinberg, Yoram Palti
Journal: Neuro-Oncology (2015)

TTFields are an effective anticancer treatment modality delivered via continuous, noninvasive application of low intensity, intermediate frequency, alternating electric fields. This innovative treatment approach is approved for the treatment of patients with recurrent glioblastoma and a recent phase 3 study demonstrated superior progression free and overall survival in newly diagnosed glioblastoma patients when TTFields were added to standard of care. The goal of this study was to evaluate the therapeutic responsiveness of genetically defined glioma cells, specifically the status of p53 tumor suppressor gene as a determinant of tumor response to TTFields. For in vitro studies, TTFields (1.75 V/cm RMS, 200 kHz) were applied for 72 hours using the inovitro™ system (Novocure, Haifa, Israel). The surviving fractions of glioma cell lines expressing either wild-type (wt) p53 (A-172 and U-87 MG) or mutant p53 (U-118 MG and F-98 rat glioma) were determined using cell counts and clonogenic assays. Induction of apoptosis was examined using flow cytometry based on Annexin V and 7-AminoactinomycinD (7-AAD) staining. Detection of caspase activity was conducted using a poly caspase assay kit. The effect of caspase inhibition was explored using the Z-VAD-FMK pan-caspase inhibitor. Application of TTFields in-vitro led to a significant reduction in cell count and clonogenic potential as compared to untreated cells in both p53 wt and p53 mutant cell lines. Flow cytometry analysis of Annexin V and Propidium Iodide staining revealed that TTFields-induced apoptosis is independent of p53 status. Caspase activity was increased in wt p53 cells following TTFields application, however no increase was observed in mutant p53 cells. Treatment of wt p53 cells with Z-VAD-FMK partially impaired cytotoxicity induced by TTFields treatment and completely abrogated apoptosis. In summary, our results suggest that TTFields exposure induces apoptosis by both p53-dependent and p53-independent pathways.
Design Approaches to Myocardial and Vascular Tissue Engineering
Authors: Olukemi O. Akintewe, Erin G. Roberts, Nae-Gyune Rim, Michael A.H. Ferguson, Joyce Y. Wong
Journal: Annual Review of Biomedical Engineering (2017)

Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising prevascularization design approaches for introducing vasculature into engineered tissues. Although we focus on encouraging blood vessel formation within myocardial implants, we also discuss techniques developed for other tissues that could eventually become relevant to engineered cardiac tissues. Because the ultimate solution to engineered tissue vascularization will require collaboration between wide-ranging disciplines such as developmental biology, tissue engineering, and computational modeling, we explore contributions from each field.
Deferasirox–Deferoxamine Combination Therapy Reduces Cardiac Iron With Rapid Liver Iron Removal In Patients With Severe Transfusional Iron Overload (HYPERION)
Authors: Yesim Aydinok, Antonis Kattamis, M Domenica Cappellini, Amal El-Beshlawy, Raffaella Origa, Mohsen Elalfy, Yurdanur Kilinç, Silverio Perrotta, Zeynep Karakas, Vip Viprakasit, Dany Habr, Antje Wegener, Junwu Shen, John B Porter
Journal: Blood (2013)
Target Dose Adjustment of Oral Busulfan Using a Test Dose in Japanese Adults Undergoing Hematopoietic Stem Cell Transplantation.
Authors: Yasushi Takamatsu, Kentaro Ogata, Noriaki Sasaki, Shuuji Hara, Tetsuya Eto, Kouji Kato, Kouji Nagafuji, Yasunobu Abe, Akira Kubota, Ilseung Choi, Rie Imamura, Yutaka Imamura, Naoya Taira, Junji Suzumiya, Kazuo Tamura
Journal: Blood (2005)
Synergy in Apoptosis Is Achieved in B-NHL by the Combination of Rituximab and the Novel Proteasome Inhibitor NPI-0052: Pivotal Role of Induction of the Immune Surveillance Cancer Gene Product RKIP
Authors: Mario I. Vega, Melisa Martinez- Paniagua, Sara Huerta-Yepez, Eriko Suzuki, Kazuo Umezawa, Kam Yeung, Massimo Libra, Stavroula Baritaki, Michael A. Palladino, Benjamin Bonavida
Journal: Blood (2008)
Early Recurrence Patterns Following Totally Intracorporeal Robot-assisted Radical Cystectomy: Results from the EAU Robotic Urology Section (ERUS) Scientific Working Group
Authors: Justin W. Collins, Abolfazl Hosseini, Christofer Adding, Tommy Nyberg, Anthony Koupparis, Edward Rowe, Matthew Perry, Rami Issa, Martin C. Schumacher, Carl Wijburg, Abdullah E. Canda, Melvin D. Balbay, Karel Decaestecker, Christian Schwentner, Arnulf Stenzl, Sebastian Edeling, Saša Pokupić, Fredrik D’Hondt, Alexander Mottrie, Peter N. Wiklund
Journal: European Urology (2016)
COMPARISON OF SELECTED MORPHOLOGICAL AND RHEOLOGICAL PARAMETERS OF BLOOD IN A GROUP OF OLDER LONG DISTANCE RUNNERS AND UNTRAINED MEN
Authors: J Kubica, J Szymura, M Więcek, M Maciejczyk, Z Szyguła
Journal: British Journal of Sports Medicine (2016)

The aim of the study was to compare morphological and rheological properties of blood of long distance runners and untrained men. The study was carried out on 20 healthy males of age about 60 years old: 10 long distance runners and 10 untrained men. There was no difference between compared groups in age, body height and body weight. Venous blood for rheological, morphological and fibrinogen analysis was sampled in the morning time. Comparison of trained men to untrained men showed higher mean values of erythrocyte elongation index at shear stress levels from 2.2 Pa to 60.0 Pa in trained men. We observed no differences in mean values of aggregation indices (AI, %), the half time (T1/2, s) and amplitude and total extent of aggregation (AMP, arbitrary units) between groups. In both groups mean differences of morphological parameters of blood were not statistically significant. In a group of long-distance runners the level of fibrinogen was lower than in a group of untrained men. The study revealed modulating effect of physical activity on haemorheological properties of blood.