tbuckley/cabot-search huggingface dataset:
Genetic Control of Embryonic Growth and Differentiation&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: Gluecksohn-Waelsch, Salome
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Genetic Control of Embryonic Growth and Differentiation Get access Salome Gluecksohn-Waelsch Salome Gluecksohn-Waelsch Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, N. Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 629–636, https://doi.org/10.1093/jnci/15.3.629 Published: 01 December 1954
QT-interval prolongation inright precordial leads
Authors: Maria Vittoria Pitzalis, Matteo Anaclerio, Massimo Iacoviello, Cinzia Forleo, Pietro Guida, Rossella Troccoli, Francesco Massari, Filippo Mastropasqua, Sandro Sorrentino, Andrea Manghisi, Paolo Rizzon
Journal: Journal of the American College of Cardiology (2003)
Occurrence of a Primary Liver Carcinoma in a Rhesus Monkey Fed Aflatoxin B 1 2
Authors: Richard H. Adamson, Pelayo Correa, Dan W. Dalgard
Journal: JNCI Journal of the National Cancer Institute (1973)

A primary liver carcinoma occurred in a rhesus monkey given aflatoxin B1 orally for 6 years. The fact that this tumor rarely arises spontaneously in monkeys, and pathologic changes seen in the liver of other monkeys given aflatoxin B1 suggested that the neoplasm was induced by this compound.
Third-line Targeted Therapy in Metastatic Renal Cell Carcinoma: Results from the International Metastatic Renal Cell Carcinoma Database Consortium
Authors: J. Connor Wells, Igor Stukalin, Craig Norton, Sandy Srinivas, Jae Lyun Lee, Frede Donskov, Georg A. Bjarnason, Haru Yamamoto, Benoit Beuselinck, Brian I. Rini, Jennifer J. Knox, Neeraj Agarwal, D. Scott Ernst, Sumanta K. Pal, Lori A. Wood, Aristotelis Bamias, Ajjai S. Alva, Ravindran Kanesvaran, Toni K. Choueiri, Daniel Y.C. Heng
Journal: European Urology (2016)
Medicine and Politics
Authors: John Lister
Journal: New England Journal of Medicine (1970)

THE most recent dispute between the doctors and the Government has illustrated just how much the affairs of the National Health Service and the medical profession are influenced by political events. Right up to the time of the general election on June 18 relations between the profession, led by the British Medical Associates, and the Government appeared to be at an impasse. Under pressure from the Association the Labour Government published, on June 4, the recommendations of the Kindersley Review Body on doctors' pay, which had been delivered to the Government two months earlier and which, it was suspected, were . . .
MB-03LONG TERM FOLLOW-UP OF PATIENTS WITH METASTATIC (M+) AND OTHER HIGH-RISK MEDULLOBLASTOMA WITH TAILORED-DOSES HYPERFRACTIONATED ACCELERATED RADIOTHERAPY (HART) CRANIOSPINAL IRRADIATION (CSI) PLUS/MINUS HIGH-DOSE THIOTEPA
Authors: Maura Massimino, Lorenza Gandola, Filippo Spreafico, Veronica Biassoni, Francesca Buttarelli, Elisabetta Schiavello, Emilia Pecori, Emanuele Pignoli, Tommaso Giandini, Roberto Luksch, Michela Casanova, Andrea Ferrari, Monica Terenziani, Geraldina Poggi, Marta Podda, Cristina Meazza, Serena Catania, Stefano Chiaravalli, Nadia Puma, Manila Antonelli, Felice Giangaspero
Journal: Neuro-Oncology (2016)
Soundings: And how is sir today?
Authors: Colin Douglas
Journal: BMJ (2000)

A long time ago, when I was a lean young surgeon lieutenant drifting agreeably on locum duties through a series of naval ships and establishments, the calm of the sickbay would be ruffled from time to time by the arrival of a patient of the lofty rank of commander or captain. In one naval air station I learnt to my surprise that even admirals got ill sometimes.

In sickbays these great beasts of the naval jungle (so to speak) created certain problems. Petty officers would feel compelled to straighten their shoulders and glower at sailors inclinced to slouch around the place as usual. Time would be found, paths smoothed, and the wearers of brass hats—the peaks of the caps of commanders and above are indeed richly blazoned with gold braid—would be ushered tactfully through the amiable muddle of the morning, so that suddenly I would find one sitting opposite me.

No one had told me how to deal with them. The easy bit was the medicine. Their seniority, however, was a problem for both of us. I did my best, perhaps like a zoo keeper faced with a large, nervous, and possibly dangerous new resident. I would let them settle down, more or less on their own terms, giving them time to accommodate to the possibility that a lowly lieutenant—and a reservist at that—might be usefully placed to advise and even help them. Some were easy, some skittish and oddly jocular, a few difficult, none impossible.

I thought of them again the other day. No longer as lean and junior as once I was, I had occasion after a long interval to see a GP. A greying, teaching hospital consultant now, I sat opposite a pleasant and poised young man who seemed not markedly older than the medical students I had just been taking through the basics of my specialty.

I tried not to be nervous. If he did too it did not show. He took time and let me settle down, and offered just enough in the way of not visibly ironic respect to put me at my ease. When we got down to the medicine he was concise and competent. I emerged not only reassured but impressed too by his zoo keeping skills. And as with my brass hats of long ago, the medicine was the easy bit.

I emerged not only reassured but impressed too
Development of and Clinical Experience with a New TV Monitoring System in Electronic Endoscopy
Authors: H. Okano, T. Kodama, T. Takino
Journal: Endoscopy (1988)

We developed a bi-plane TV monitoring system using a TV endoscope (Electronic endoscope manufactured by Toshiba-Machida, Tokyo, Japan) that permits simultaneous display of real-time and prerecorded images. Various findings of the two examinations can be precisely compared using this system, and a detailed evaluation of the progress of peptic ulcers obtained. In addition, the effects of various endoscopic therapies can be accurately evaluated. In endoscopic injection sclerotherapy of esophageal varices, new varices (or recurrent varices) were differentiated. In laser therapy for early gastric cancer, precise delimitation of the lesion for radiation was possible, and the therapeutic effects were more accurately evaluated. These results show the diagnostic as well as therapeutic usefulness of this system. Furthermore, for the examination of the lower digestive tract, X-ray images were incorporated into this system. This is a useful modality for diagnostic and therapeutic procedures in colonic disease.
Behaviour of the pandemic H1N1 influenza virus in Andalusia, Spain, at the onset of the 2009-10 season
Authors: J M Mayoral Cortés, L Puell Gómez, E Pérez Morilla, V Gallardo García, E Duran Pla, J C Fernandez Merino, J Guillén Enriquez, J C Carmona, G Andérica, I Mateos, J M Navarro Marí, M Pérez Ruiz, A Daponte
Journal: Eurosurveillance (2009)

In Andalusia, Spain, the pandemic influenza A(H1N1)v virus has spread throughout the community, being the dominant influenza strain in the season so far. The current objective of the Andalusia Health Service is focussed on the mitigation of the health and social impact by appropriate care of the patients at home or in health centres. The 2009-10 seasonal influenza epidemic started early compared with to previous seasons. This article analyses the influenza A(H1N1)v situation in Andalusia until the week 39/2009.
Controversies in psychiatric education: a survey of residents' attitudes
Authors: J F Greden, J I Casariego
Journal: American Journal of Psychiatry (1975)

The authors administered a questionnaire including statements regarding controversies in psychiatric education to 86 residents in six programs in the Washington, D.C./Baltimore, Md., area. The residents were asked for their opinions on educational policies, ideological issues in psychiatry, their identification with traditional areas of medicine, and future regulatory practices for psychiatry. The data gathered show some shifts in attitudes among first-second-, and third-year residents. They also show a marked inclination toward dynamic-analytically oriented psychotherapy. The authors conclude that substantial changes will be required in the core curriculum of residency education if the prediction that tomorrow's psychiatrist will be a complete psychobiologist is to be fulfilled.
Understanding the Adverse Effects of Ticagrelor in Practice
Authors: Christopher B. Granger, Peter B. Berger
Journal: JAMA Cardiology (2016)

Marc P. Bonaca, MD, MPH; Deepak L. Bhatt, MD, MPH; Ton Oude Ophuis, MD; P. Gabriel Steg, MD; Robert Storey, MD, DM; Marc Cohen, MD; Julia Kuder, MPH; Kyungah Im, PhD; Giulia Magnani, MD; Andrzej Budaj, MD, PhD; Pierre Theroux, MD; Christian Hamm, MD; Jindřich Špinar, MD; Robert G. Kiss, MD; Anthony J. Dalby, MD; Felix A. Medina, MD; Frederic Kontny, MD, PhD; Philip E. Aylward, MD; Eva C. Jensen, MD, PhD; Peter Held, MD, PhD; Eugene Braunwald, MD; Marc S. Sabatine, MD, MPH
PCM-10PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE FOLLOWING INTRAVENOUS, INTRANASAL, AND INTRATHECAL ADMINISTRATION IN A NON-HUMAN PRIMATE MODEL
Authors: Cynthia M. Lester McCully, Louis Rodgers, Rafael Cruz, Cody Peer, William D. Figg, Katherine E. Warren
Journal: Neuro-Oncology (2016)

PCM-10. PLASMA AND CEREBROSPINAL FLUID PHARMACOKINETICS OF 5-AZACYTIDINE FOLLOWING INTRAVENOUS, INTRANASAL, AND INTRATHECAL ADMINISTRATION IN A NON-HUMAN PRIMATE MODEL Cynthia M. Lester McCully, Louis Rodgers, Rafael Cruz, Cody Peer, William D. Figg, Sr., and Katherine E. Warren; National Cancer Institute, Bethesda, MD, USA BACKGROUND: Promoter-associated hypermethylation resulting in transcription silencing has been identified in epigenetic cancer pathways for pediatric high-grade gliomas. The pyrimidine analog, 5-azacytidine (AZA), is a DNA demethylating agent that covalently binds DNA methyltransferases. The resulting hypomethylation may reactivate tumor suppressor genes and generate an antitumor effect. AZA has demonstrated activity in a pre-clinical murine astrocytoma model following systemic administration (Borodovsky, et . To evaluate the CNS exposure of AZA, plasma and CSF pharmacokinetics (PK) were examined in a nonhuman primate model following systemic (intravenous [IV] and intranasal [IN]) and intrathecal (IT) administration. METHODS: AZA was administered to rhesus macaques; IV (n 1⁄4 4), IN (n 1⁄4 1), and IT (n 1⁄4 3). Serial paired plasma and CSF samples were collected. AZA was quantified via an LC-MS/MS assay and PK parameters calculated using noncompartmental methods. RESULTS: IV-One animal was unevaluable. Mean peak plasma concentration (Cmax) was 1.54 ug/ml, half-life 0.21 min, AUC0-1 0.729 hr*ug/ml. No AZA concentrations were quantifiable in the CSF. IN-One plasma sample (0.102 ug/ml) at 5 min and no CSF samples were quantifiable. ITMean plasma Cmax 0.0268 ug/ml, half-life 1.08 hr, AUC0-1 0.0622 hr*ug/ml. Mean CSF values were: Cmax 125.43ug/ ml, half-life 1.16hr, AUC0-1 296.58 ug/ml*hr. A moderate transient pleocytosis in the CSF was noted at 24hr, resolved by 48 hr, and no clinical or neurological toxicity was noted. CONCLUSIONS: Systemic delivery of AZA, following IV or IN administration, does not provide adequate CSF exposure. However, IT delivery was tolerable and resulted in substantial and sustained CSF drug levels without evidence of neurologic toxicity. Neuro-Oncology 18:iii139–iii144, 2016. doi:10.1093/neuonc/now080.10 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
No benefit from the obesity paradox for diabetic patients with heart failure
Authors: Elisabet Zamora, Josep Lupón, Cristina Enjuanes, Domingo Pascual‐Figal, Marta de Antonio, Mar Domingo, Josep Comín‐Colet, Joan Vila, Judith Peñafiel, Núria Farré, Núria Alonso, Javier Santesmases, Maribel Troya, Antoni Bayés‐Genís
Journal: European Journal of Heart Failure (2016)
Sodium 18F-Fluoride Bone Scintigraphy in Deep Ocean Diver
Authors: Jin T.E. Lim, Valeria M. Moncayo, Naomi Alazraki
Journal: Clinical Nuclear Medicine (2015)

Sodium ¹⁸F-fluoride (NaF) is a diagnostic marker for new bone formation in bone scintigraphy that was approved by US FDA in 1972 but discontinued in 1984. We report a case of a US naval officer who spent time living and working in an oceanic lab, 205 feet below the surface. Plain skeletal films of femurs 4 years later demonstrate bilateral bone infarcts. Corresponding sodium ¹⁸F-fluoride bone scintigraphy demonstrates low-normal to decreased tracer activity. This rectilinear scan image is of historical interest. Other bone scintigraphic radiotracers used in the past and present will be briefly discussed.
Inhibition of 5-Fluorouracil Activation by Oxipurinol in Preparations of Normal Rat Tissues and Jensen Sarcoma: Tumor-Selective Stimulation by Inosine
Authors: R E Beltz, L L Poland
Journal: Cancer Communications (1991)

The effects of inosine on oxipurinol-induced inhibition of 5-fluorouracil (FUra) activation were investigated in a transplantable rat tumor and three normal rat tissues in vitro. FUra activation directed toward RNA was assessed in preparations of small intestine and Jensen sarcoma by determining the uptake of 14C-labeled FUra into purified total RNA of each tissue under identical conditions of incubation. Oxipurinol reduced the incorporation of FUra into intestinal RNA by as much as 93% but inhibited FUra uptake into tumor RNA by only about 45%. In the presence of sufficient oxipurinol to induce inhibition at approximately these levels, inosine failed to stimulate FUra uptake into intestinal RNA, whereas 0.1 mM inosine restored FUra uptake into Jensen sarcoma RNA to the level found in oxipurinol-free controls, and 0.5 mM inosine increased FUra uptake 29% above the controls. Both tissues had a nearly equivalent enzymatic capacity to cleave inosine by phosphorolysis. In view of what is currently known about the mechanism of action of oxipurinol and the metabolism of inosine, these results suggested that under our in vitro conditions rat small intestine was incapable of utilizing ribose-1-phosphate derived from inosine to stimulate the conversion of FUra to 5-fluorouridylate (FUMP), whereas Jensen sarcoma efficiently used this source of ribose-1-phosphate to increase the production of FUMP from FUra. In the absence of oxipurinol, inosine increased FUra uptake into total RNA of Jensen sarcoma by as much as 57%, compared to inosine-free controls, but markedly inhibited FUra uptake into total RNA of the small intestine.(ABSTRACT TRUNCATED AT 250 WORDS)
Hyperkinetic/aggressive boys in treatment: predictors of clinical response to methylphenidate
Authors: J Loney, R J Prinz, J Mishalow, J Joad
Journal: American Journal of Psychiatry (1978)

Data on 84 nonretarded boys aged 6--12 with the hyperkinetic/MBD syndrome were drawn from a comprehensive, longitudinal investigation in the interest of identifying factors that contribute significantly to variation in clinically rated improvement during treatment with methylphenidate. The size of the multiple correlation (R = .50) indicates that 25% of the variation in the children's response to methylphenidate is jointly predictable from age at referral, degree of perinatal complications, and score on the hyperactivity factor. The authors discuss stepwise multiple regression analysis as the method of choice in drug response prediction studies and the possible effects on the results of such studies of differing definitions of improvements.
Immunisation coverage in the European Union
Authors: N Guérin, C Roure
Journal: Eurosurveillance (1997)

The 15 countries of the European Union have ratified the fifth objective of Health for all in the year 2000 programme of WHO Europe, which states: “By the year 2000, there should be no indigenous cases of poliomyelitis, diphtheria, neonatal tetanus, measl
Histological features of advanced colorectal adenomas detected by endoscopy and fecal immunochemical test
Authors: Mauro Risio, Cesare Hassan, Antonino Sottile, Alberto Saglia, Nereo Segnan, Carlo Senore
Journal: Endoscopy (2015)

<b>Background and study aims:</b> The detection of advanced adenomas within organized screening programs using either immunochemical fecal occult blood test (FIT) or endoscopy has been associated with the prevention of colorectal cancer. The histological changes and pathogenetic mechanisms that lead to the detection of such lesions by either of these screening methods have not yet been addressed. <b>Patients and methods:</b> The histological specimens of 50 advanced adenomas detected by FIT were compared with those of 50 advanced adenomas detected by primary endoscopy screening that were matched for size and histology. The following variables were systematically recorded: 1) histopathological changes compatible with luminal bleeding induced by ischemia; 2) hypoxia in the adenomatous tissue, assessed through the expression of carbonic anhydrase IX; and 3) microvessel quantitative analysis, evaluated by CD31 and CD105 immunostains. All specimens were reviewed blindly by an expert gastrointestinal pathologist. <b>Results:</b> Histopathological changes associated with ischemia-related luminal bleeding were significantly more frequent in FIT-positive than in endoscopy-detected advanced adenomas (78 % vs. 14 %; <i>P</i> < 0.001). Carbonic anhydrase IX expression was also significantly higher in FIT-detected advanced adenomas (immunohistochemical score: 12.0 vs. 4.1; <i>P</i> < 0.001). Conversely, no differences were found in microvessel density. <b>Conclusions:</b> The detection of advanced adenomas by FIT screening appears to be related to ischemia-associated luminal bleeding, which, in turn, may be due to periods of hypoxia. The absence of such changes in endoscopy-detected advanced adenomas would suggest that the two screening methods may be complementary for the detection of advanced neoplasia within organized screening programs.
Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice
Authors: Redouane Bouchaala, Luc Mercier, Bohdan Andreiuk, Yves Mély, Thierry Vandamme, Nicolas Anton, Jacky G. Goetz, Andrey S. Klymchenko
Journal: Journal of Controlled Release (2016)

Lipid nanocarriers are considered as promising candidates for drug delivery and cancer targeting because of their low toxicity, biodegradability and capacity to encapsulate drugs and/or contrasting agents. However, their biomedical applications are currently limited because of a poor understanding of their integrity in vivo. To address this problem, we report on fluorescent nano-emulsion droplets of 100nm size encapsulating lipophilic near-infrared cyanine 5.5 and 7.5 dyes with a help of bulky hydrophobic counterion tetraphenylborate. Excellent brightness and efficient Förster Resonance Energy Transfer (FRET) inside lipid NCs enabled for the first time quantitative fluorescence ratiometric imaging of NCs integrity directly in the blood circulation, liver and tumor xenografts of living mice using a whole-animal imaging set-up. This unique methodology revealed that the integrity of our FRET NCs in the blood circulation of healthy mice is preserved at 93% at 6h of post-administration, while it drops to 66% in the liver (half-life is 8.2h). Moreover, these NCs show fast and efficient accumulation in tumors, where they enter in nearly intact form (77% integrity at 2h) before losing their integrity to 40% at 6h (half-life is 4.4h). Thus, we propose a simple and robust methodology based on ratiometric FRET imaging in vivo to evaluate quantitatively nanocarrier integrity in small animals. We also demonstrate that nano-emulsion droplets are remarkably stable nano-objects that remain nearly intact in the blood circulation and release their content mainly after entering tumors.
Biological and Chemical Warfare
Authors: E M Darre, T Gregersen
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Normal neuropsychological abilities of alcoholic men in their late thirties
Authors: I Grant, K Adams, R Reed
Journal: American Journal of Psychiatry (1979)

The neuropsychological performance of alcoholic men in their late 30s (mean age, 37 years), some of whom has been abstinent for 3 weeks and others for 18 months, was compared with that of a group of men who drank occasionally. There were no differences between the alcoholic groups and the comparison group that could not be attributed to normal aging. The number of years of alcoholism or estimated lifetime alcohol use, dietary adequacy, and medical or blackout history did not relate to neuropsychological impairment. The authors suggest that a simple "dose-effect" relationship between alcohol use and cognitive decline cannot be assumed.
Impact Of Systemic Antibiotic Prophylaxis In Hematopoietic Stem Cell Transplantation Recipients. A Meta-Analysis Of Randomized Controlled Trials
Authors: Shun-ichi Kimura, Hiroshi Nakano, Tomotaka Ugai, Hidenori Wada, Ryoko Yamasaki, Yuko Ishihara, Koji Kawamura, Kana Sakamoto, Masahiro Ashizawa, Miki Sato, Kiriko Terasako-Saito, Hideki Nakasone, Misato Kikuchi, Shinichi Kako, Junya Kanda, Rie Yamazaki, Aki Tanihara, Junji Nishida, Yoshinobu Kanda
Journal: Blood (2013)