tbuckley/cabot-search huggingface dataset:
Diagnostic Value of SPECT Bone Scintigraphy for Odontogenic Maxillary Sinusitis
Authors: TSUYOSHI NISHIMURA, TADAHIKO IIZUKA
Journal: Clinical Nuclear Medicine (2001)

Purpose The aim of this study was to assess the diagnostic value of bone SPECT for odontogenic maxillary sinusitis and bone activity in the alveolar process to clarify the pathophysiologic nature of the disease. Materials and Methods Computed tomography and bone SPECT with Tc-99m HMDP were performed in 28 patients with odontogenic maxillary sinusitis. Based on the findings of the computed tomographic images, the inflammatory changes in the maxillary sinus mucosa (mucosal lesions) were evaluated horizontally and vertically. For the initial diagnosis, visualization of the causative site by bone SPECT was compared with conventional radiographic and planar findings. SPECT data were used to assess bone activity by calculating the mean count ratios of the alveolar process over the cervical vertebrae. The relation of bone activity to the structure of the mucosal lesions, the presence of clinical symptoms, mucosal changes around the maxillary ostium (ostial lesions), and conventional radiolucent images around the causative teeth (periapical lesions) were assessed. Results Identification of the causative site was sufficiently specific in bone SPECT images. Bone activity was significantly correlated with the structure of the mucosal lesions, both horizontally and vertically, and with the presence of infraorbital symptoms, ostial lesions, and periapical lesions. Conclusions It is important to view odontogenic maxillary sinusitis as a bone disease in which the bone activity associated with alveolar osteitis affects the pathophysiologic nature of the disease. Bone SPECT is valuable to make a more precise diagnosis, thereby allowing more appropriate treatment of the disease.
HIGH-SENSITIVITY CARDIAC TROPONIN I AND RISK OF HOSPITALISATION WITH HEART FAILURE IN PATIENTS WITH SUSPECTED ACUTE CORONARY SYNDROME: A COHORT STUDY
Authors: Dominik Stelzle, Anoop Shah, Martin Denvir, Atul Anand, Fiona Strachan, Andrew Chapman, Nicholas Mills, David McAllister
Journal: Journal of the American College of Cardiology (2016)
Abstract 1908: MDR1 gene overexpression confers resistance to C-MET inhibitor in multidrug resistant cancer cell line
Authors: Tsai-Hsien Hung, Yu-Hsin Li, Kowit-Yu Chong
Journal: Cancer Research (2012)

Abstract c-MET signaling is implicated in a wide variety of human malignancies. Hepatocyte growth factor (HGF) binding to the proto-oncogenic c-MET receptor lead to activate multiple tyrosine kinase signaling pathway. Inappropriate c-MET signaling in cancer can enhance tumor cell proliferation, survival, motility, and invasion. Recently, several reports have indicated that inhibition of c-MET signaling induced apoptosis in a variety of cancer cells and recognized as a novel anticancer therapy approach. Previous study from our laboratory also showed that the higher mRNA expression level of HGF, and its downstream genes including HGF receptor (c-Met) and urokinase (uPA) were detected in drug resistant Dx5-C5 cell compared with parental human uterus sarcoma MES-SA cell line. Furthermore, report indicated that the constitutive expression of P-glycoprotein (P-gp) is involved in the HGF/MET related pathway of MDR-positive human hepatocellular carcinoma cell line. Moreover, MDR1 gene overexpressed leukemia cell line also shown more resistance to tyrosine kinase inhibitor imatinib mesylate. These finding suggested that chemoresistant cancer cells may also develop a similar mechanism to against c-MET inhibitor. Our results shown: when treated both cell cancer lines with c-MET inhibitor PHA665752, we found that compared to parental MES-SA cells, the Dx5-C5 cells with highly expressed P-gp was more resistant to PHA665752, the resistance was also reversed by co-treatment of MDR inhibitor verapamil and PHA665752. In addition, when transfection of c-MET shRNA into Dx5-C5 and MES-SA cell line for 48 hrs, we found that the viability was decreased in the c-MET shRNA transfected Dx5-C5 cell line in a dose dependent manner but not in the MES-SA cell line. In conclusion, our study demonstrated that existence of P-glycoprotein in MDR cell line would attenuate c-MET inhibitor induced cell death and may help us to develop a new strategy for treatment of multiple drug resistance cancer cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1908. doi:1538-7445.AM2012-1908
Leiomyosarcoma of the Liver Detected by High F-18 Fluorodeoxyglucose Positron Emission Tomographic Uptake
Authors: S Nishiguchi, S Shiomi, S Ofuji, H Ishizu, Y Iwata, N Sasaki, S Minamitani, H Ochi
Journal: Clinical Nuclear Medicine (2001)

NISHIGUCHI, SHUHEI M.D.,*; SHIOMI, SUSUMU M.D.,*; OFUJI, SATOKO M.D.,*; ISHIZU, HIROTAKA M.D.,*; IWATA, YOSHINORI M.D.,*; SASAKI, NOBUMITSU M.D.,*; MINAMITANI, SHIN M.D.*; OCHI, HIRONOBU M.D.† Author Information
Catastrophic complication of ingestion of corrosive substance
Authors: Vishal Sharma, Surinder Rana, Puneet Chhabra, Yalaka Reddy, Deepak Bhasin
Journal: Endoscopy (2014)

A 35-year-old man presented 7 days after ingestion of lye with symptoms of complete dysphagia, odynophagia, drooling of saliva, and cough. He had taken lye in a fit of rage, and this was followed by the onset of these symptoms. He had tachypnea, tachycardia, and bilateral crackles in the chest. He was referred to us for insertion of a nasojejunal tube for enteral feeding.
Correction: Corrigendum: A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
Authors: Vineet D Menachery, Boyd L Yount, Kari Debbink, Sudhakar Agnihothram, Lisa E Gralinski, Jessica A Plante, Rachel L Graham, Trevor Scobey, Xing-Yi Ge, Eric F Donaldson, Scott H Randell, Antonio Lanzavecchia, Wayne A Marasco, Zhengli-Li Shi, Ralph S Baric
Journal: Nature Medicine (2016)
Balloon overtube-assisted stenting in difficult upper and lower gastrointestinal locations using a modified over-the-wire technique
Authors: Rolando Pinho, Luísa Proença, Ana Ponte, Carlos Fernandes, Iolanda da Ribeiro, Joana Silva, João Carvalho
Journal: Endoscopy (2014)

In this series of four patients, some modifications of the standard over-the-wire (OTW) technique for stent deployment using the balloon overtube normally used in single-balloon enteroscopy are presented. This modified technique allowed the use of OTW stents in patients where there were difficulties that meant the standard technique was unsuccessful. For each patient, the authors describe different small novel adaptations of this modified technique that enabled self-expanding metal stents (SEMSs) and biodegradable stents to be successfully deployed in different gastrointestinal locations. Moreover, in one patient the stent was placed without fluoroscopic guidance.
Catching a Wave — Implementing Health Care Reform in California
Authors: Andrew B. Bindman, Andreas G. Schneider
Journal: New England Journal of Medicine (2011)

The Affordable Care Act (ACA) has launched a wave of federal funding and policy changes that will extend health insurance coverage to 32 million Americans beginning in 2014. Many states have been resisting this wave by asking the federal courts to strike down the ACA on constitutional grounds. Others are preparing to catch it. Among the latter states is California, where despite a 12.3% unemployment rate and major budget problems, implementation is under way.The stakes for Californians and their physicians are enormous. The state is expected to have more newly insured people than any other state: approximately 3.4 million. . . .
AB1040 The incidence of previously undiagnosed conditions in patients attending fracture liaison service
Authors: R. Abdulkader, C. Dharmapalaiah, S. Stephenson, G. Clunie
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The role of a fracture liaison service (FLS) is significant not only in secondary fracture prevention but also in the identification of medical conditions adversely affecting bone metabolism. Addressing these conditions aims at improving bone health and general wellbeing. <h3>Objectives</h3> We have reviewed the incidence of new medical conditions identified through routine investigations in patients aged 50-80y seen in The FLS in our unit (fracture cases &gt;80y not included). <h3>Methods</h3> All patients who attend The FLS clinic (age 50-80y) have an assessment including review of past history, DXA scan, blood tests U&amp;Es, bone profile, PTH, thyroid function test, Vitamin D, CRP. Additionally in patients &gt;70y old, serum protein electrophoresis is checked. Male patients are tested for hypogonadism. We retrospectively reviewed patients attending FLS clinic who were identified with a previously-undisclosed medical condition between November 2008 and October 2011.We reviewed FLS and any subsequent clinic letters and the Hospital laboratory database. We did not include new diagnoses of vitamin D deficiency or cases where increased falls tendency was identified and investigated. <h3>Results</h3> Over this 3-year period, 2876 patients (aged 50-80) attended the FLS clinic. Review resulted in the identification of 74 cases (2.5%) of previously undiagnosed medical conditions relevant to poor bone health. Of these cases 28 (1%) were found to have primary hyperparathyroidism (PHPT) and 5 patients were found to have paraproteinemia (3 cases of monoclonal gammopathy of unknown significance and 2 still under investigation). Hypogonadism was identified in 19 men (15 primary hypogonadism, 4 secondary [2 with hyperprolactinemia]). Other cases identified included: hyperthyroidism (4), celiac disease (1), hypothyroidism (11), inflammatory arthritis (2) and chronic kidney disease 3-5 (2). In 2 patients, review was inconclusive owing to loss of follow-up; one may have had PHPT and a male patient with possible hypogonadism. <h3>Conclusions</h3> In our FLS, routine and simple screening disclosed new medical conditions, relevant to bone health in 2.5% fracture cases (age 50-80y). Notably the incidence of PHPT detected our fracture patients aged 50-80y is at least 10 times its incidence in the general population (1% vs 0.1%).We suggest that 1% is an underestimate in fracture patients overall though as screening was not designed to capture any new PHPT in those &gt;80y. <h3>Disclosure of Interest</h3> None Declared
Psyllium Fiber Reduces Abdominal Pain in Children With Irritable Bowel Syndrome in a Randomized, Double-Blind Trial
Authors: Robert J. Shulman, Emily B. Hollister, Kevin Cain, Danita I. Czyzewski, Mariella M. Self, Erica M. Weidler, Sridevi Devaraj, Ruth Ann Luna, James Versalovic, Margaret Heitkemper
Journal: Clinical Gastroenterology and Hepatology (2016)
Abstract A7: Combined copy number and expression analysis of formalin fixed-paraffin embedded (FFPE) tumours
Authors: Mahesh Iddawela, Oscar Rueda, Yuker Wang, Malek Faham, Mohamed El-Sheemy, Ged Cowley, Jennifer Eremin, Oleg Eremin, Helena Earl, Carlos Caldas
Journal: Clinical Cancer Research (2010)

Abstract Introduction: FFPE tissues are a valuable source of tumour material for translational research that has thus far been under-used. But progress in technology has allowed the analysis of genome wide copy number and expression changes using small amounts of degraded DNA/RNA extracted from FFPE tissues. We used two platforms: molecular inversion probes assay (MIP, Affymetrix) and c-DNA mediated Annealing Selection extension and Ligation assay (DASL, Illumina™) for analysis of RNA/DNA extracted from routine core biopsies from a clinical trial to identify molecular markers of response or resistance to chemotherapy. Method: FFPE diagnostic core biopsies of 63 patients treated with neoadjuvant adriamycin/cyclophosphamide followed by taxotere in a clinical study were used. MIP assay with 50K SNP panel was used for copy number analysis (CNA). DASL assay assessed expression of 502 genes using three probes per gene. Results: RNA and DNA of good quality were extracted from 52/63 (82%) and 46/63 (73%) core biopsy samples, respectively. Gene expression profiling was carried out using the DASL assay and there were good correlations with IHC for ER, PR and HER-2 with area under the curve of 0.95, 0.90 and 0.96 respectively, following ROC analysis for the best transcripts. Differential expression analysis between ER+ vs. ER- cancers showed that ESR1, TFF1 and LAF4 are significantly over-expressed in ER + cancers (p&amp;lt;0.001), while analysis of pathological complete responders vs. non responders showed over expression of CXCL9, ARHA, ARHGDIB, BCL3, ERBB2, BMYB and TGFBI among responders (p&amp;lt;0.2). CNA showed well described aberrations in breast cancer such as high probability of gains in 1q, 8q, 11q and 20q and loss in 4q, 12q, 13q, 18q and 22q (probability of alteration ≥0.35). Samples with pathological complete response had high probability of gains in 1q (55%), 8q (40%), 17q (40%) and losses in 8p (40%) and 13q (70%). 5/46 samples were HER-2 3+ with IHC and all showed amplification around the 17q locus. Conclusions: Reliable copy number and expression data can be generated using these assays from FFPE core biopsy samples. Role of LAF4 as an oestrogen regulated gene and roles of CXCL9, ARHA and ARHGDIB as markers of response to chemotherapy should be further investigated. Citation Information: Clin Cancer Res 2010;16(7 Suppl):A7
Hematoperitoneum after small-bowel spiral enteroscopy
Authors: B. Gondal, J. Charpentier, D. Cave
Journal: Endoscopy (2013)

Advances in endoscopy including spiral enteroscopy [1] have transformed the management of small-bowel diseases, and published data have demonstrated this to be a safe procedure [2] [3] [4] [5] [6] [7] [8]. We report the first case, related to spiral enteroscopy, of hematoperitoneum in a 62-year-old woman.
Abstract 5475: National survey of malignant mesothelioma and asbestos exposure in Japan
Authors: Nobukazu Fujimoto, Kenichi Gemba, Keisuke Aoe, Katsuya Kato, Yukio Takeshima, Kouki Inai, Takumi Kishimoto
Journal: Cancer Research (2012)

Abstract A newspaper article published in June 2005 reported that 5 residents who lived near the now-closed asbestos cement pipe plant in Amagasaki developed pleural mesothelioma. The asbestos-related problems that the article described caused much social concern resulting in the so-called ‘Kubota shock.’ Patients who have a history of occupational asbestos exposure and have developed malignant mesothelioma are provided worker's compensation in Japan. However, among 878 cases of death due to mesothelioma in 2003, only 85 cases were actually compensated. Based on this, we initiated this retrospective survey and extracted 6,030 cases of death due to MM between 2003 and 2008 to clarify the clinical features of MM including the association with asbestos exposure (AE). Among them, clinical diagnosis of MM was confirmed in 929 cases. The origin of MM included the pleura in 794 (85.5%) cases, the peritoneum in 123 (13.2%) cases, the pericardium in 7 (0.8%) cases, and the testicular tunica vaginalis in 5(0.5%) cases. The histological subtype of MM included 396 (55.9%) epithelioid, 154(21.7%) sarcomatoid, 126 (17.8%) biphasic, and 33 (4.7%) cases classified as other types. AE was indicated in 76.8% and pleural plaques were detected in 34.2% of all MM cases. Asbestos particles were determined in 103 MM cases. More than 1,000 asbestos particles per gram dried lung tissue were detected in 74.8%, and more than 5,000 particles were detected in 43.7% of the cases. We compared the patient characteristics and the diagnostic procedures of MM before and after the ‘Kubota shock’. Compared to the early phase of this study (2003-2005), the median age at diagnosis of MM was higher, the number of cases without definite diagnosis of MM was lower, the proportion of cases diagnosed by thoracoscopy was higher, and the percentage of the cases in which the occupational history was described in the medical record was significantly higher in the late phase (2006-2008). Our study confirmed that more than 70% of MM cases in Japan are associated with AE. The ‘Kubota shock’ might affect some features pertaining to MM. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5475. doi:1538-7445.AM2012-5475
1115 IMPACT OF HCV TREATMENT AND DISEASE SEVERITY ON HEALTH CARE COSTS IN CHRONIC HCV PATIENTS: ANALYSIS OF A LARGE US PRIVATE HEALTH INSURANCE CLAIMS DATABASE
Authors: S.C. Gordon, P.J. Pockros, N.A. Terrault, R.S. Hoop, A. Buikema, D. Nerenz, F.M. Hamzeh
Journal: Journal of Hepatology (2012)
SAT0352 Comparison of Nonradiographic Axial Spondyloarthritis and Ankylosing Spondylitis Patients – Baseline Characteristics and Development of Clinical Variables during Three Years of Anti-TNF Therapy in Clinical Practice
Authors: J.A. Karlsson, M.C. Kapetanovic, I.F. Petersson, P. Geborek, L.-E. Kristensen
Journal: Annals of the Rheumatic Diseases (2014)

During a 12-month period 285 isolates of Neisseria species, other than Neisseria gonorrhoeae, were cultured from patients attending the Department of Venereology, Royal Infirmary, Edinburgh. There were eight patients in whom genitourinary or rectal isolates of Neisseria meningitidis or Neisseria catarrhalis were found. Differences between data from our series and from previous reports are discussed with particular regard to sites routinely cultured in female patients. We also report in vitro inhibition of N. gonorrhoeae by an isolate of N. meningitidis cultured from the cerivx of a patient.
Abstract 5678: Design of GRP78 inhibitors as novel therapeutics for breast cancer.
Authors: Kavya Ramkumar, Bikash Debnath, Amy S. Lee, Nouri Neamati
Journal: Cancer Research (2013)

Abstract Cancer cells exploit cellular stress response mechanisms, such as the unfolded protein response, to survive through cytotoxic treatments. A key mediator of the unfolded protein response, the 78kDa glucose regulated protein (GRP78) chaperone, has frequently been found to be overexpressed in breast cancer. In addition to providing a growth advantage to cancer cells, GRP78 induction leads to drug resistance. Suppressing GRP78 levels using siRNA has been shown to slow cancer cell progression and overcome drug resistance. Another approach to inactivating GRP78 is by inhibiting its ATPase activity. Currently, there are only few selective GRP78 inhibitors in development despite ample evidence of its critical role in cancer cell survival and drug resistance. Here, we report a novel class of small-molecule inhibitors of GRP78 ATPase activity. We designed a focused library of compounds based on a structure-based docking approach and screened for inhibition of GRP78 ATPase activity. Based of the initial hit, we further optimized several analogues with more potent activity and selectivity for GRP78 inhibition (IC50 &amp;lt;5μM). The lead compound, KR-240, induced CHOP significantly under conditions of ER stress and activated the pro-apoptotic arm of the unfolded protein response. KR-240 showed moderate cytotoxicity against a panel of breast cancer cell lines and increased sensitivity to chemotherapeutic agents, further supporting the role for GRP78 in cancer survival and drug resistance. Overall, our results indicate that our novel GRP78 inhibitor, KR-240 has the potential for further development as an anticancer agent. Citation Format: Kavya Ramkumar, Bikash Debnath, Amy S. Lee, Nouri Neamati. Design of GRP78 inhibitors as novel therapeutics for breast cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 5678. doi:10.1158/1538-7445.AM2013-5678
PTH-172 Outcome Assessment of the First Two Years of a New Oesophageal High Resolution Manometry Unit within a District General Hospital
Authors: N K Bhangu, S C Shieh, T Cacciattolo, S Millman, R Geary, M W Johnson
Journal: Gut (2013)

Introduction Oesophageal high resolution manometry (OHRM) is a fast developing area of medicine. Whilst seemingly being at the “cutting edge” of technological advancement, it is a relatively simple procedure to perform and interpret. Its ability to demonstrate functional as well as anatomical abnormalities, has led to a range of new diagnoses and shed light on areas of previous clinical and management dilemma. Despite this, few hospitals outside of the large central teaching hospitals, have embraced this new technology. Objective To assess the demand for OHRM within a district general hospital (DGH). To assess the reasons for referral and the general outcomes from the procedure. Methods The Luton & Dunstable Hospital set up a new OHRM service in July 2009. Prospective procedure related information was stored on a HRM database. This database was analysed to assess total number of procedures performed, the reasons for referral and the diagnostic outcome of those procedures. Results Over the course of the first 2 years, a total of 162 procedures were performed. Patients were referred in with a range of symptoms, often in combinations. Of these 162 patient 9 suffered dental problems, 31 had globus, 32 had persistent sore throat, 27 had chronic cough, 13 had nocturnal cough, 118 had endoscopic negative reflux-like symptoms, 40 had endoscopy negative dysphagia, 30 had atypical chest pains, 1 had persistent nausea, 24 had dysphonia and 2 were for reflux assessment. A wide range of diagnoses were made often in combination, including; - 52 with reduced LOS pressures, 18 with a small LOS, 58 with a hiatus hernia, 52 with acid reflux, 40 with non-acid reflux, 75 with oesophageal dysmotility, 23 with oesophageal spasm, 6 with hypertonic contractions, 19 with hypotonic dysmotility, 5 with achalasia type 2, 4 with achalasia type 3, 15 with a wide transition zone, 17 with transient LOS relaxation, 3 with poor pharyngeal co-ordination, 1 with food bolus, and 20 who were normal. Conclusion OHRM is relatively simple procedure to perform and interpret. With its ability to diagnose both functional and anatomic abnormalities it has become an invaluable part of our DGH gastroenterology unit. Given the clear benefits over standard manometry, we believe that all patients throughout UK should have access to an OHRM service. Disclosure of Interest None Declared.
Early Acute Hematogenous Osteomyelitis Detected by Bone Scintigraphy but not MRI
Authors: Wichana Chamroonrat, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2013)

Early diagnosis of acute hematogenous osteomyelitis (AHO) is crucial for effective management and to reduce the potential risk of lifelong deformities in pediatric patients. Both bone scintigraphy and MRI as current diagnostic imaging claim their high sensitivity in early detection of the disease. We present a 9-year-old girl patient with AHO in the distal right tibia, which was demonstrated on bone scintigraphy while a subsequent MRI on the same day was negative.
EFFICACY AND SAFETY OF TICAGRELOR AS LONG-TERM SECONDARY PREVENTION IN PATIENTS WITH PRIOR MYOCARDIAL INFARCTION AND PERIPHERAL ARTERY DISEASE
Authors: Marc P. Bonaca, Deepak Bhatt, Robert Storey, Philippe Steg, Marc Cohen, Julia Kuder, KyungAh Im, Peter Held, Eva Jensen, Eugene Braunwald, Marc Sabatine
Journal: Journal of the American College of Cardiology (2016)