Cardiometabolic Effects of CASCADE Trial Explained by Mediterranean Diet
Authors: Ana Marina Moreira, Thizá M. Londero, Iuri M. Goemann, Beatriz D. Schaan
Journal: Annals of Internal Medicine (2016)

Letters19 April 2016Cardiometabolic Effects of CASCADE Trial Explained by Mediterranean DietAna Marina Moreira, MD, Thizá M. Londero, MD, Iuri M. Goemann, MD, and Beatriz D. Schaan, MD, PhDAna Marina Moreira, MDFrom Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil., Thizá M. Londero, MDFrom Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil., Iuri M. Goemann, MDFrom Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil., and Beatriz D. Schaan, MD, PhDFrom Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0015_1 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The CASCADE (Cardiovascular Diabetes and Ethanol) trial (1) is the first long-term randomized clinical trial that evaluated the effect of moderate wine consumption on glycemia and lipid profile in an alcohol-abstaining diabetic population. Patients were randomly assigned to regularly drink water, red wine, or white wine at dinner and were also advised to follow a Mediterranean diet. They participated in group sessions guided by a clinical dietitian monthly for the first 3 months and quarterly thereafter for 2 years.Some study details should be addressed. All 3 groups had improved lipid profiles after 6 months that were ...References1. Gepner Y, Golan R, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Shelef I, et al. Effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type 2 diabetes: a 2-year randomized, controlled trial. Ann Intern Med. 2015;163:569-79. [PMID: 26458258]. doi:10.7326/M14-1650 LinkGoogle Scholar2. Esposito K, Maiorino MI, Bellastella G, Chiodini P, Panagiotakos D, Giugliano D. A journey into a Mediterranean diet and type 2 diabetes: a systematic review with meta-analyses. BMJ Open. 2015;5:e008222. [PMID: 26260349] doi:10.1136/bmjopen-2015-008222 CrossrefMedlineGoogle Scholar3. Shai I, Wainstein J, Harman-Boehm I, Raz I, Fraser D, Rudich A, et al. Glycemic effects of moderate alcohol intake among patients with type 2 diabetes: a multicenter, randomized, clinical intervention trial. Diabetes Care. 2007;30:3011-6. [PMID: 17848609] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOf InterestForms.do?msNum=L16-0015. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoEffects of Initiating Moderate Alcohol Intake on Cardiometabolic Risk in Adults With Type 2 Diabetes Yftach Gepner , Rachel Golan , Ilana Harman-Boehm , Yaakov Henkin , Dan Schwarzfuchs , Ilan Shelef , Ronen Durst , Julia Kovsan , Arkady Bolotin , Eran Leitersdorf , Shoshana Shpitzen , Shai Balag , Elad Shemesh , Shula Witkow , Osnat Tangi-Rosental , Yoash Chassidim , Idit F. Liberty , Benjamin Sarusi , Sivan Ben-Avraham , Anders Helander , Uta Ceglarek , Michael Stumvoll , Matthias Blüher , Joachim Thiery , Assaf Rudich , Meir J. Stampfer , and Iris Shai Metrics Cited byFlavones: From Biosynthesis to Health Benefits 19 April 2016Volume 164, Issue 8Page: 573-574KeywordsAlcoholsBlood plasmaDietGlucoseHbA1cHigh density lipoprotein cholesterolHypoglycemicsLipid profilesWine ePublished: 19 April 2016 Issue Published: 19 April 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...