tbuckley/cabot-search huggingface dataset:
Abstract LB-267: A role for the Sin3 histone deacetylase complex in cell migration
Authors: Karen T. Smith, Skylar A. Martin-Brown, Chris Seidel, Arcady Mushegian, Rhonda Egidy, Laurence Florens, Michael P. Washburn, Jerry L. Workman
Journal: Cancer Research (2012)

Abstract Histone deacetylases (HDACs) remove acetyl groups from histones and other proteins, leading to alterations in protein activity and gene expression. Drugs that target these enzymes (HDAC inhibitors or HDACis) are currently approved for the treatment of specific cancers and are under study in numerous additional clinical trials. These drugs work by causing cell cycle arrest, differentiation or apoptosis. However, less is known about their potential effects on cancer cell migration and invasion, processes implicated in metastasis. There are eleven human zinc dependent histone deacetylases and many HDACis target several of these structurally related proteins in cells. Our studies are focused on HDACs1 and 2 which reside in large protein complexes, one of which is the Sin3 complex. This complex is important for promoter-mediated histone deacetylation, transcriptional repression and cell cycle control. We previously found that specific HDACis disrupt the function of the Sin3 complex in distinct ways. Here we describe the function of a novel subunit of the Sin3 complex, a previously uncharacterized protein, named “Family with sequence similarity 60, member A” (FAM60A). We find that FAM60A represses expression of genes linked to cancer cell migration and invasion. Moreover, we show that loss of FAM60A, or a core subunit of the Sin3 complex can increase the migration of lung cancer cells. This suggests that not all HDAC-related functions are cancer promoting, and adds to data suggesting that some HDAC-related functions may act in steps in metastasis suppression pathways. This suggests that some HDACis could increase the potential for metastasis. Current studies are focused on delineating the cancer-promoting functions of the complex from those that are tumor or metastasis suppressive and testing the effects of specific HDACis on cancer cell migration and invasion. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-267. doi:1538-7445.AM2012-LB-267
Abstract 5352: Novel treatment approaches in retinoblastoma: Impact of combination therapy on tumor burden
Authors: Samuel K. Houston, Christina Decatur, Timothy G. Murray, Nikesh Shah, Ludimila Cavalcante, Yolanda Pina
Journal: Cancer Research (2011)

Abstract Purpose: The purpose of the current study is to examine vessel targeting, chemotherapy, and mammalian target of rapamycin (mTOR) inhibitor agents in LHBETATAG retinal tumors and their impact on tumor burden. Methods: Group A: Ten-week-old, LHBETATAG mice (n=30) received a single subconjunctival injection of anecortave acetate (AA; 1200, 600, 300, and 150 µg) delivered to right eyes only. Group B: Ten-week-old, LHBETATAG mice (n=30) received a single subconjunctival injection of AA (600, 300, and 150 µg) delivered to right eyes only, either during a cycle of carboplatin (six subconjunctival deliveries) or after the completed cycle. Carboplatin was delivered at the subtherapeutic concentration of 62.5 µg. All animals were euthanatized at 16 weeks of age, and the eyes were examined histopathologically. Group C: Eighteen-week-old, LHBETATAG mice received (n=30) subconjunctival injections of rapamycin once weekly for two consecutive weeks (0.00333, 0.167, 3.33, and 6.67 mg/kg). Tumor sections were analyzed for tumor burden with immunohistochemistry techniques. Results: A statistically significant reduction in tumor burden was detected after a single periocular injection of AA. The reduction of tumor burden followed a U-shaped dose-response curve. Tumor burden was significantly decreased when AA and carboplatin were combined. However, varying doses and delivery schedule of these agents had significant impact on the effectiveness of the combined treatment. The most effective scheme was delivering a low dose (150-300 µg) of AA after a complete cycle of carboplatin. Reduction in tumor burden were significantly different between rapamycin doses and control (p&amp;lt;0.002). Eyes treated with rapamycin at 0.167, 3.33 and 6.67 mg/kg showed a significant decrease in tumor burden in comparison with the vehicle control group (p=0.019, p=0.001, p=0.009, respectively) and the 0.00333 mg/kg dose response (p=0.023, p=0.001, p=0.010, respectively). Histopathological evaluation showed no signs of retinal toxicity to either treatment used. Conclusions: AA, as monotherapy or as adjuvant therapy, significantly controlled tumor burden in a murine model of retinoblastoma. Moreover, adjuvant therapy enabled the use of typically subtherapeutic carboplatin doses without decreasing efficacy of the therapy. Inhibition of mTOR reduced tumor burden during late disease in the LHBETATAG retinoblastoma tumor model. Rapamycin may have a role in combination with chemotherapy or other adjuvant therapies to enhance retinoblastoma tumor control. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 5352. doi:10.1158/1538-7445.AM2011-5352
Abstract 4991: Upregulation and the role of IKBKE in non-small cell lung cancer
Authors: Donghwa Kim, Jianping Guo, Jingchun Gao, Shaokun Shu, Eric B. Haura, Jin Q. Cheng
Journal: Cancer Research (2011)

Abstract IKBKE is a serine/threonine protein kinase that belongs to the IKK kinase family. Recent studies have shown IKBKE as a breast and ovary cancer oncogene. Here we evaluated IKBKE expression and kinase activity in 30 NSCLC cell lines and 176 primary NSCLC specimens including 38 tumor/normal lung tissue pairs. Elevated protein levels of IKBKE were detected in 16 (52.6%) cell lines and 91 (51.7%) primary tumors. The mRNA levels and kinase activity of IKBKE are consistent with its protein status, suggesting that post-transcriptional regulation is not involved in increase IKBKE protein expression and that the IKBKE activation largely depends on its protein levels in NSCLCs. In addition, ectopic expression of IKBKE decreases and depletion of IKBKE increases the apoptosis induced by chemotherapeutic agents. Moreover, IKBKE is considerably induced by tobacco-derived carcinogens NNK and nicotine through Stat3 pathway. These findings demonstrated for the first time that deregulation of IKBKE is a recurrent event in NSCLC and could play a pivotal role in NSCLC development, and thus IKBKE is a critical therapeutic target in this malignancy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4991. doi:10.1158/1538-7445.AM2011-4991
Use of renal transplants from living donors
Authors: A S Daar, P. J Morris, D. Cranston
Journal: BMJ (1999)

Surgical techniques should be fully evaluatedEditor-The editorial by Nicholson and Bradley on renal transplantation from living donors rightly pointed out that the United Kingdom has a lower rate of transplantations which use kidneys from living donors than the United States or Norway. 1 The recent report by the Royal College of Surgeons on organ transplantation in the United Kingdom recommended that steps should be taken to increase the use of kidneys from living donors in the United Kingdom to offset the shortage of cadaveric kidneys as well as to improve outcome. 2 In the United Kingdom in 1998, 38% more transplantations were performed using organs from living donors than in 1997.However, there is still some way to go if a level similar to that of the United States or Scandinavia (25-30%) is to be achieved.Nicholson and Bradley identify the risks associated with donor nephrectomy and state that much of the morbidity that occurs after open nephrectomy is related to the wound.For this reason they believe that the use of laparoscopically assisted donor nephrectomy needs to be examined in the light of the experience of, for example, the Johns Hopkins Hospital in Baltimore, Maryland.However, there have been no randomised prospective trials of this procedure, which takes longer than open nephrectomy.Furthermore, all of the non-randomised comparisons have been of open nephrectomy performed through a loin incision, with or without removal of a rib.If an anterior
Crowned Dens Syndrome
Authors: Masami Matsumura, Satoshi Hara
Journal: New England Journal of Medicine (2012)

An 88-year-old woman presented with a 2-month history of recurrent episodes of acute pain in her neck and knees that were associated with fevers of 38 to 39.3°C. She reported no visual symptoms, jaw claudication, morning stiffness, or pain in the upper arms or shoulders. Radiography revealed chondrocalcinosis in the knees and stippled calcifications in the pubic symphysis. Computed tomography of the neck showed curvilinear calcifications of the transverse ligament of the atlas (Panel A, arrows), a linear calcification (Panel B, arrows), and crown-shaped calcium deposits surrounding the odontoid process (Panel C, arrowheads). Crowned dens syndrome is characterized by recurrent . . .
Esophageal bezoar in a patient with esophageal epiphrenic diverticulum
Authors: Y. Chen, M. Tsai, T. Chen, C. Lin
Journal: Endoscopy (2013)

A 57-year-old woman presented with dysphagia and postprandial epigastric fullness for about two years. Esophagogastroduodenoscopy (EGD) showed a esophageal diverticulum at the lower portion of the esophagus, and barium swallow esophagography showed a focal outpouching space (measured about 5 cm in size) at the distal third of the esophagus near the esophagogastric junction ([Fig. 1]). The patient reported having nausea and vomiting after eating in the past 2 days. She underwent another EGD, which revealed a 3-cm, blackish bezoar impacted in the esophageal diverticulum ([Fig. 2]). The bezoar was removed with a snare basket. On reviewing her history, it was found that she had been taking Pho Pu Zi (Cordia dichotoma Forst. f.) as an appetizer for a month.
731 HOW OFTEN DOES HEPATOCELLULAR CARCINOMA HAVE A TYPICAL PATTERN IN CONTRAST ENHANCED ULTRASOUND (CEUS)?
Authors: A.F. Martie, I. Sporea, R.L. Sirli, A.S. Popescu, M. Danila, V.N. Chiriac, D. Gherhardt, D. Suseanu
Journal: Journal of Hepatology (2012)
TCTAP A-208 Twelve-month Angiographic and Clinical Outcomes Following Infrapopliteal Artery Intervention in Patients with Critical Limb Ischemia
Authors: Sung Il Im, Seung-Woon Rha, Byoung Geol Choi, Se Yeon Choi, Yoonjee Park, Akkala Raghavender Goud, Hu Li, Sunki Lee, Ji Bak Kim, Jin Oh Na, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2014)
Abstract 1551: Irradiation enhances tumor-homing ability of monocytes as cellular carrier.
Authors: Ching-Fang Yu, Christopher W. Woo, Shao-Hua Lo, Chia-Yi Yen, Ji-Hong Hong, Chi-Shiun Chiang
Journal: Cancer Research (2013)

Abstract Tumor-homing ability of monocytes renders them as potential cellular delivery system for alternative cancer therapy, but the migration ability is reduced after reagents are up-taken. Approaches that can enhance monocyte tumor homing and migration abilities will facilitate the clinical value of using monocytes as cellular carrier. Previous studies have shown that irradiation (IR) could promote macrophage aggregation into the hypoxic regions. To investigate whether IR could enhance the infiltration of bone marrow-derived monocytes (BMDMs) into tumors, the infiltration of BMDMs prepared from GFP-transgenic mice were examined by fluorescence microscopy in murine prostate adenocarinoma TRAMP-C1 model. The results showed that IR did not increase the initial infiltration number of BMDMs, but enhanced the retention of monocytes within IR-treated tumors up to 2 weeks. This study also showed that BMDMs were able to uptake various imaging or therapeutic agents, but their mobility was decreased as the load was increased. However, when BMDMs were differentiated in IR-treated tumor condition medium (IR-CM), the nanoparticles-loaded migration loss was recovered in both in vitro and in vivo models. The prolong retention of monocytes within irradiated tumor tissues and the ability of IR-CM to enhance the migration ability of cargo-loaded BMDMs suggest that pre-conditioned monocytes could be a potential cellular carrier for target therapy following conventional RT. (This study is supported by NHRI-EX101-10132BI and NSC101-2627-M-007-001 grants) Citation Format: Ching-Fang Yu, Christopher W. Woo, Shao-Hua Lo, Chia-Yi Yen, Ji-Hong Hong, Chi-Shiun Chiang. Irradiation enhances tumor-homing ability of monocytes as cellular carrier. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1551. doi:10.1158/1538-7445.AM2013-1551
Abstract 3011: Correlation of PERK activation with increased GRP78-binding in UVB-irradiated HaCaT cells
Authors: Lingying Tong, Shiyong Wu
Journal: Cancer Research (2012)

Abstract Ultraviolet (UV) light has been shown to be a potential human carcinogen, and it is widely accepted that UV exposure can impact protein expression via both transcriptional and translational regulation. PERK is one of the eIF2α kinases that is activated and inhibits protein synthesis upon UV irradiation. However, the mechanism for UV-induced PERK activation is not fully elucidated. In this study, we evaluated the role of GRP78/BiP, an inhibitory PERK-binding protein, in the regulation of PERK activity in UVB irradiated cells. Our data showed that while PERK expression was reduced in both human keratinocytes (HaCaT) and mouse embryonic fibroblasts (MEF) cells, GRP78/BiP expression remained steady in HaCaT and slightly increased in MEF cells after UVB irradiation. Our data also showed that the Tyr phosphorylation of PERK, an indication of activation, was increased after UVB irradiation, which confirmed the role of PERK in UV-induced translational regulation. Unexpectedly, a co-immunoprecipitation analysis indicated PERK activation was accompanied with an increase in PERK-bound GRP78/BiP in the irradiated HaCaT cells. Based on these results, we propose that UV-induced PERK activation might be GRP78/BiP-independent, and its activation pathway in HaCaT cells may be unique from other cell lines. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3011. doi:1538-7445.AM2012-3011
Upside-down stomach repositioned and fixed by colonoscopy-assisted percutaneous endoscopic gastrostomy
Authors: Yosho Fukita, Hiroyuki Ishibashi, Ikuma Yasuda, Tsutoshi Asaki, Seitaro Adachi, Michifumi Toyomizu, Yoshiki Katakura
Journal: Endoscopy (2014)

Upside-down stomach is a rare condition characterized by the occurrence of a gastric volvulus in a supradiaphragmatic hernia sac [1] [2]. We describe a case of upside-down stomach with mesenteroaxial volvulus in which the stomach had prolapsed into the esophageal hiatal hernia sac. The gastric volvulus was successfully resolved by colonoscopy-assisted PEG.
Abstract 2791: Blood C-reactive protein levels and colon cancer risk
Authors: Gong Yang, Wong-Ho Chow, Xiao-Ou Shu, Honglan Li, Yongbing Xiang, Wanqing Wen, Butian Ji, Nathaniel Rothman, Xianglan Zhang, Qiuyin Cai, Yu-Tang Gao, Wei Zheng
Journal: Cancer Research (2010)

Abstract Background: Circulating C-reactive protein (CRP), a sensitive marker of low-grade systemic inflammation, has been associated with an increased risk of colon cancer in some but not all studies. Few studies have evaluated the association by the time interval between blood collection and cancer diagnosis. Objective: To prospectively evaluate the association between blood CRP levels and colon cancer risk, as well as the potential effect of time window of CRP measures on the association. Design: A nested case-control study of 209 cases of colon cancer and 279 controls identified from the Shanghai Women's Health Study with up to 10 years of follow-up. Conditional logistic regression was used to estimate odds ratios (OR) of developing colon cancer and their 95% confidence intervals (CI) associated with blood CRP levels. Results: Blood CRP levels were positively associated with colon cancer risk (P trend = 0.003). Women in the highest quartile of CRP had an adjusted OR of 2.52 (95% CI: 1.36 − 4.70) compared with women in the lowest quartile. The risk was higher for women whose CRP was measured in blood collected ≤5 years prior to diagnosis (OR for the highest quartile of CRP = 3.67; 95% CI: 1.41 − 9.56; P for trend = 0.006), compared to women with samples collected &amp;gt;5 years before diagnosis (corresponding OR = 1.98; 95% CI: 0.83 − 4.74; P for trend = 0.15). Conclusion: Our findings support the hypothesis that low-grade systemic inflammation is associated with an increased risk of colon cancer. Cancer-induced inflammation may partly explain the observed association. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2791.
Post-Operative Outcomes in Non-Small Cell Lung Cancer Patients with Mild to Moderate Stage Chronic Obstructive Pulmonary Disease
Authors: R. Itotani, S. Marumo, S. Kumagai, K. Yamanashi, J. Tokuno, R. Sumitomo, T. Shoji, C. Huang, M. Fukui
Journal: Annals of Oncology (2015)
PLAQUE MORPHOLOGY CAN BE A PREDICTOR OF FUTURE CORONARY EVENTS IN RELATION TO LESIONS OF DEFERRED FRACTIONAL FLOW RESERVE-NEGATIVE STENOSIS
Authors: Daisuke Higashioka, Yoshiki Matsuo, Takashi Kubo, Yoshinori Asae, Hiroki Emori, Yasunori Yamamoto, Tomoko Nakamura, Akira Taruya, Haruhi Nishio, Tsuyoshi Nishiguchi, Ikuko Teraguchi, Yasutsugu Shiono, Makoto Orii, Takashi Yamano, Yasushi Ino, Tomoyuki Yamaguchi, Kumiko Hirata, Atsushi Tanaka, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2015)
Colony-Stimulating Factors in Cultures of Human Peripheral Blood Cells&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: J T Prival, M Paran, R C Gallo, A M Wu
Journal: JNCI Journal of the National Cancer Institute (1974)

Conditioned media containing colony-stimulating factors (CSF) were prepared in culture from unfractionated leukocytes and a lymphocyte-rich fraction of human peripheral blood. The mitogen phytohemagglutinin increased CSF production in low concentrations (106 cellsjml) of lymphocytes in the presence of homologous human plasma. In a semisolid agar medium system, the leukocyte-conditioned medium stimulated growth of granulocytic cell clones both from mouse and from human marrow cells; the lymphocyte-conditioned medium stimulated those from human marrow cells but had little or no activity with mouse marrow cells. This low colony-stimulating effect on mouse marrow cells was not due to the presence of inhibitors. The findings indicated that there were at least two types of CSF with respect to species specificity, that the lymphocyte-rich fraction contained CSF-producing cells, and that the factor(s) relatively specific for human cells could be separated from less specific factors.
The Role of Hematopoietic Stem Cell Transplant in Follicular Lymphoma
Authors: Edward A. Faber, Julie M. Vose
Journal: Journal of the National Comprehensive Cancer Network (2010)

Substantial progress has been made in the clinical management of patients with follicular lymphoma over the past 2 decades. However, the role of autologous and allogeneic stem cell transplantation in these patients remains controversial. Myeloablative chemotherapy or radioimmunotherapy supported by autologous hematopoietic cell transplantation has been shown to lead to a longer progression-free survival and, in some studies, improved survival over standard therapy. However, in the era of rituximab-based therapies used as part of induction or salvage, these historical trials may not be representative. Allogeneic stem cell transplantation offers the advantages of a tumor-free graft and some immunologic graft-versus-lymphoma effects. However, fully myeloablative transplants have high morbidity and mortality rates. Dose-reduced conditioning regimens followed by allogeneic hematopoietic cell transplantation have substantially reduced treatment-related mortality and perhaps will produce better outcomes long-term. This article outlines some historical information regarding stem cell transplantation for follicular lymphoma and discusses recent modifications that may improve outcomes, such as adding radioimmunotherapy to autologous stem cell transplantation or using alternative dose-reduced regimens that could benefit patients with reduced toxicities.
Large cohort study is launched to find causes of stroke and dementia in India
Authors: D. Sachan
Journal: BMJ (2014)

India and the Netherlands have jointly launched a large cohort study to examine the causes of stroke and dementia in the Indian population.1

The study will be conducted by the All India Institute of Medical Sciences in New Delhi, in collaboration with the National Brain Research Centre in Manesar, Haryana, and Erasmus MC, the medical centre of Erasmus University in Rotterdam, the Netherlands.

India’s Department of Biotechnology, which is part of the Ministry of Science and Technology, has earmarked 340m rupees (£3.3m; €4m; $5.4m) for the project, which is slated to start in a year’s time. A …
Abstract SY06-03: Exploiting the dependency of cancer cells on molecular chaperone systems
Authors: Paul Workman
Journal: Cancer Research (2011)

Abstract Please see attachment link below for the complete presentation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr SY06-03. doi:10.1158/1538-7445.AM2011-SY06-03
SP0060 Potential New Strategies for Inhibiting Prostaglandins
Authors: P.-J. Jakobsson
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Microsomal prostaglandin E synthase-1 (mPGES-1) constitutes a drug target for inflammation, fever and pain. mPGES-1 catalyzes the biosynthesis of prostaglandin (PG) E<sub>2</sub> from cyclooxygenase (Cox) -derived PGH<sub>2</sub>, which in turn is derived from arachidonic acid. mPGES-1 is mainly associated with inflammation and it is known to be up regulated by various pro-inflammatory cytokines like IL-1 beta and TNF-alpha. Mice devoid of mPGES-1 activity display resistance to development of experimental arthritis, fever, pain, symptoms following stroke, atherosclerosis and breathing anomalies induced by hypoxia. Conversely, the enzyme seems to have a protective role in wound healing and remodeling following myocardial infarction. Inhibitors of mPGES-1 have been developed by several groups. However, their characterization in animal models of inflammation, or other models previously used to study mPGES-1 knock-out mice, remains limited. One reason is the fact that a majority of the potent inhibitors of human mPGES-1 are significantly less potent or even completely inactive towards rodent mPGES-1. In addition, the impact of mPGES-1 inhibitors on the prostaglandin profile should be further investigated in various cells and in vivo systems, as their effects but also side-effects will largely depend on the particular prostaglandin profile they elicit. In this presentation, an update will be provided on the characterization of mPGES-1 inhibitors by us and others. <h3>Disclosure of Interest</h3> P.-J. Jakobsson Consultant for: NovaSAID AB <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6215