tbuckley/cabot-search huggingface dataset:
Abstract 4531: Fucosylated haptoglobin is a novel type of cancer biomarker linked to the prognosis after an operation in colorectal cancer
Authors: Shinichiro Shinzaki, Yuri Takeda, Kenta Moriwaki, Kohei Murata, Eiji Miyoshi
Journal: Cancer Research (2012)

Abstract Background: Fucosylation is a crucial oligosaccharide modification in cancer and inflammation. Total cellular proteins of cancer cells and the sera of patients with cancer both show increased fucosylation levels. Certain kinds of fucosylated proteins can be applied as novel cancer biomarkers in glyco-proteomic analyses. We previously identified fucosylated haptoglobin (Fuc-Hpt) as a serologic marker for pancreatic cancer, and recently developed a lectin-antibody enzyme-linked immunosorbent assay system for quantifying Fuc-Hpt. In the present study, we investigated the clinical outcome of Fuc-Hpt levels in patients with colorectal cancer (CRC), and examined the mechanisms underlying Fut-Hpt production using a murine tumor transplantation model. Methods: The relationship between Fuc-Hpt levels and clinical parameters was investigated in 77 patients with CRC, all of whom underwent primary resection. Serum Fuc-Hpt levels were examined in athymic nude mice injected with colon cancer cell lines that lacked fucosylation. Results: Fuc-Hpt levels were significantly associated with overall and relapse-free survival, distant metastasis, clinical stage, and curability. Multivariate analysis revealed that distant metastasis was an independent factor for increased Fuc-Hpt levels. The combination of Fuc-Hpt and CEA might be a better serologic marker to predict prognosis. Fuc-Hpt levels were higher in mice with direct injection of tumor cells into the spleen than in those injected subcutaneously. Conclusions: Fuc-Hpt might be a useful marker for the prognosis of CRC. Fuc-Hpt could be produced by the tissue surrounding tumor cells, which might be the mechanism underlying Fuc-Hpt elevation associated with distant metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4531. doi:1538-7445.AM2012-4531
AB1054 Prevalence of radiological hand osteoarthritis and chondrocalcinosis in patients with calcium pyrophosphate deposition:
Authors: E. Ilinykh, A. Smirnov, V. Barskova
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To study the prevalence of radiological osteoarthritis and chondrocalcinosis (CC) of hand in patients with Calcium pyrophosphate deposition (CPPD) and its correlation with clinical manifestations. <h3>Methods</h3> 60 pts with CPPD were included in the study. Arthritis of different localizations was observed in all pts. Hand involvement occurred in 35 (58,3%) pts. Diagnosis CPPD was confirmed by the identification of CPP crystals in synovial fluid of the knees and radiological and/or ultrasound signs of chondrocalcinosis. All pts underwent bilateral posteroanterior hand radiographs. Two radiological signs were estimated: CC and radiological hand osteoarthritis at Kellgren-Lawrence grade (KLG)≥2. <h3>Results</h3> Mean age of pts was 58,8±11,4years, 60%&gt;men and 40% - women. Radiological typical CC was identified in 53,3% pts. Bilateral CC was defined in 25% pts. Results of X-ray for hand-joint groups are submitted in the table 1. Radiological OA (KLG≥2) have been observed more frequently in the distal joints of the hands, than in the wrist (d=0,025), while the CC prevailed in the wrist (d=0,0067). Radiological HOA and CC did not correlate with hand arthritis on the moment of investigation. Correlation between radiological grades HOA and age of patients has been taped (d &lt;0,05). The X-ray pattern testifies to more expressed changes in the DIP of the right hand, than the left (p=0,0422). <h3>Conclusions</h3> More than half pts with CPPD developed arthritis of the hand joints (58%) with most common localization in the wrist. Radiological OA and CC were common signs in60 ptswith CPPD, either. Radiological HOA have been more expressed in the distal joints of the hands and CC in the wrist. Nevertheless, there were no statistical correlation between radiological grade HOA, CC and development of hand arthritis in pts with CPPD. <h3>Disclosure of Interest</h3> None Declared
MULTISLICE COMPUTED TOMOGRAPHY IMAGING OF TRANS-CATHETER AORTIC VALVE IMPLANTATION IN DIFFERENT BICUSPID AORTIC VALVE ANATOMIES
Authors: Hiroyuki Kawamori, Yoshio Maeno, Yigal Abramowitz, Nobuyuki Takahashi, Yoshio Kazuno, Mohammad Kashif, Tarun Chakravarty, Wen Cheng, Raj Makkar, Hasan Jilaihawi
Journal: Journal of the American College of Cardiology (2016)
Norms for reasoning about decisions
Authors: Jean-François Bonnefon
Journal: Behavioral and Brain Sciences (2011)

Abstract Reasoning research has traditionally focused on the derivation of beliefs from beliefs, but it is increasingly turning to reasoning about decisions. In the absence of a single, entrenched normative model, the drive toward normativism is weaker in this new field than in its parent fields. The current balance between normativism and descriptivism is illustrated by three approaches to reasoning about decisions.
P3-03-07: A Novel Approach Integrating microRNA and mRNA Signatures of HMAPK Signaling Is Highly Predictive of ER- Status and Outcome in Breast Cancer – Role of HMAPK microRNAs in Repression of ER and p27.
Authors: P Miller, J Clarke, T Koru-Sengul, J Brinkman, D El-Ashry
Journal: Cancer Research (2011)

Abstract Deregulation of the MAPK signaling pathway in breast cancer is known to facilitate the down-regulation of the estrogen receptor and to contribute to the aggressive nature of ER negative and triple negative breast cancers. We have identified a microRNA signature indicative of hyperactive MAPK (hMAPK) signaling, which complements a previously established hyperactive MAPK gene expression signature. We have shown that hMAPK signaling also alters the regulatory activity of many microRNAs, including particular microRNAs with established roles in the biology of breast cancer, miR-221/222 and miR-22. Expression correlation with both the hMAPK microRNA signature and hMAPK mRNA signature is significantly associated with ER-negative status, increased tumor grade, high proliferation rate, and, importantly, poor disease specific survival among breast cancer patients, regardless of ER status. The hMAPK microRNA signature contains 127 microRNAs, 47 up-regulated and 70 down-regulated. Of note, hMAPK up-regulated microRNAs include miR-221/222 and 22, both of which have been demonstrated to target ER while miR-221/222 targets the cell cycle regulatory protein p27. Down-regulated microRNAs include miR-375, which positively regulates ER expression by down-regulating expression of an ER repressor. miR-221/222 and miR-22 exhibit both enhanced expression and enhanced regulatory activity in the context of hMAPK signaling, indicating an important role for these microRNAs in the biology of hMAPK signaling in breast cancer. In addition to these microRNAs, an unbiased approach of determining MAPK regulated microRNAs targeting the 3’ UTRs of both ER and p27 will identify novel microRNAs involved in the MAPK regulated repression of ER and p27. These data not only suggest a regulatory role for microRNAs whose expression and biological activity are altered under conditions of hyperactivation of MAPK signaling in establishing and maintaining ER negativity and tumor aggression, but also indicate that hMAPK signaling may represent a novel aggressive tumor biology that is indicative of poor disease outcome in breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P3-03-07.
Abstract 4184: Development of ixabepilone-induced CIPN is related to pre-treatment with paclitaxel in a mouse model
Authors: Karen-Sue B. Carlson, Anita Ramnarain, Sidney Strickland, Linda T. Vahdat
Journal: Cancer Research (2010)

Abstract The mechanisms and underlying factors that predispose individuals to development of chemotherapy-induced peripheral neuropathy (CIPN) are not clearly understood. CIPN results in the dose attenuation, delay, or discontinuation of drug in patients otherwise responding to chemotherapy. Moderate to severe CIPN can interfere with function and activities of daily living. Microtubule-stabilizing agents, including taxanes and epothilones are strongly associated with development of CIPN. Ixabepilone, the first FDA-approved epothilone, is specifically used in taxane-resistant metastatic breast cancer. Any ixabepilone-induced CIPN may be as high as 71% depending on administration regimen. Specific risk factors for development of this side effect are unknown. Here we present data using a murine model of sensory hyperalgesia that suggests pretreatment with paclitaxel, currently a labeling indication for use of ixabepilone in metastatic breast cancer, is itself a predisposing factor for development of ixabepilone-induced peripheral neuropathy. Wild type DB/A2 adult mice were treated with intraperitoneal 25 mg/kg paclitaxel, 2.5 mg/kg ixabepilone, or diluent (cremophor: ethanol) every other day for 4 doses. Mice were analyzed by rota-rod to test sensory-motor function and by hot and cold plate to test for temperature hyperalgesia. There was no difference in performance of either of the three treatment groups following the initial treatment cycle. Mice were then treated with a further cycle of chemotherapy, either the same as they received initially, except that half of the paclitaxel-treated group was crossed-over to ixabepilone. Rota-rod and hot plate testing again failed to show a difference between groups. However, cold-plate testing showed a statistically significant increase in cold hyperalgesia in mice treated first with paclitaxel followed by ixabepilone in comparison to all other treatment groups. EM and immunofluorescence analyses of dorsal root ganglia and sciatic nerve sections from mice in all four treatment groups are ongoing. Although preliminary, these results suggest that prior chemotherapy regimens have a significant effect on development of CIPN in this model. The exact mechanisms of injury are under evaluation. A complementary clinical study is underway in women with breast cancer to understand the effect of ixabepilone on an ultrastructural level and its potential role in the development of peripheral neuropathy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4184.
Definitive Diagnosis of Cerebrospinal Fluid Leak Into the Pleural Space Using 111In-DTPA Cisternography
Authors: Brandon A Howard, Linda Gray, Robert E Isaacs, Salvador Borges-Neto
Journal: Clinical Nuclear Medicine (2014)

A 58-year-old woman with a calcified disk extrusion causing severe spinal stenosis underwent T8 to T9 diskectomy and spinal fusion. A postoperative pseudomeningocele was treated with lumbar drain and fibrin glue. Performed for persistent right pleural effusion, CT myelogram failed to show communication between the cerebrospinal fluid (CSF) and pleural space—even on 2-hour delayed images. Subsequent 111In-DTPA cisternogram clearly demonstrated CSF leakage into the right pleural space at 2 hours, and surgical repair yielded good results. Radionuclide cisternography is a highly useful method to detect CSF leak, especially when it is occult on CT yet suspected clinically.
Ga-67 Scintigram in the Diagnosis of Infection of Masticator Muscles Due to an Odontogenic Infection
Authors: H Sakamoto, Y Suzuki, D Watanabe, N Yanagimachi, J Sasaki
Journal: Clinical Nuclear Medicine (2000)

A 36-year-old man had a mandibular swelling and severe difficulty opening his mouth. His left lower wisdom tooth had been extracted 2 days before. He had a high fever (39°C), leukocytosis (9,300/ml), and an elevated C-reactive protein level (9.66 mg/ml). Ga-67 scintigraphy showed intense uptake in the mandible and masticator muscles. SPECT images displayed in maximum intensity projection format clearly defined the inflamed internal and external pterygoid muscles and masseter and temporalis muscles. Although each masticator muscle was severely swollen by the infection, the fascial structure was well preserved. Repeated antibiotic therapy ultimately controlled the infection.
Interactive effects of low-dose estradiol and tamoxifen on the postmenopausal primate endometrium and mammary gland.
Authors: CE Wood, M Cline
Journal: Cancer Research (2009)

Abstract Abstract #3047 Background: Long-term use of combined estrogen+progestin hormone therapies increases breast cancer risk in postmenopausal women. Selective estrogen receptor modulators (SERMs) are promising alternatives to progestins, particularly for breast cancer survivors and other women at high-risk for breast cancer considering hormone therapy. The purpose of this study was to evaluate interactive effects of low-dose estradiol (E2) and the SERM tamoxifen on the postmenopausal endometrium and mammary gland.&amp;#x2028; Materials and Methods: Ovariectomized adult female cynomolgus monkeys were given placebo (n=6), oral estradiol (E2, 0.25 mg/1800 kcal) (n=6), tamoxifen (TAM, 20 mg/1800 kcal) (n=5), or E2+TAM (n=6) for 4 months. Doses of E2 and TAM were scaled to approximate those given to women.&amp;#x2028; Results: Endometrial thickness and uterine weight were significantly higher in E2, TAM, and E2+TAM groups compared to placebo (P &amp;lt; 0.01 for all). In contrast, endometrial gland and stromal proliferation determined by Ki67 immunolabeling was significantly greater only in the E2 group (P &amp;lt; 0.01 for both). Endometrial Ki67 gene expression was also higher only in the E2 group (P &amp;lt; 0.01). Gene markers of estrogen receptor alpha (ER) activity such as TFF1 and STC2 were significantly increased in E2, TAM, and E2+TAM groups (P &amp;lt; 0.01 for all). On endometrial histology TAM and E2+TAM induced stromal fibrosis and occasional simple glandular hyperplasia with cystic change. In the mammary gland, TFF1 gene expression was increased by all treatments (P &amp;lt; 0.05 for all), while no statistically significant treatment effects were seen for epithelial proliferation or progesterone receptor expression.&amp;#x2028; Discussion: Previous studies have suggested that the weak estrogen-like effects of tamoxifen in the uterus contribute to increased endometrial cancer risk. Our findings reveal a more complex pattern of tamoxifen action involving increased ER activity, antagonism of E2-induced proliferation, and distinctive stromal remodeling. These results suggest that tamoxifen does not exhibit simple weak estrogen agonist / antagonist effects in the primate endometrium but instead acts through pathways independent of classical ER signaling to alter cancer risk. Future gene profiling should aid in the identification of these alternative pathways. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3047.
Abstract 4802: Metabolic distinctions in high grade epithelial ovarian cancer
Authors: Behrouz Zand, Justin Bottsford-Miller, Wei Hu, Rebecca Stone, Alpa M. Nick, Xinna Zhang, Koen De Geest, Susan K. Lutgendorf, Anil K. Sood
Journal: Cancer Research (2012)

Abstract Objective: To identify differences in overall metabolite profile of human high grade serous epithelial ovarian cancers (EOC) compared to normal ovarian tissues. Methods: Forty-five patient tissues were obtained (n= 30 EOC, n= 15 normal). Samples were analyzed by Gas Chromatography (GC)/mass spectrometry (MS) and Liquid Chromatography (LC)/MS platforms. The difference between the groups was reported in fold change (FC). Welch's two sample t-tests were used to identify metabolites that differed significantly between cancer and normal ovarian tissues and p&amp;lt;0.05 was defined as significant. Results: Using an existing library containing &amp;gt;2000 metabolites, there were 315 metabolites that were identified between EOC and normal ovaries. Of these 315 metabolites, 204 were significantly altered with 180 up regulated metabolites, and 24 down regulated. EOC had altered metabolism in the glycolytic, amino acid, lipid, nucleotide and eicosanoid pathways. There was an increase dependence on glycolysis consistent with the “Warburg effect,” as noted by elevated glucose-6-phosphate (FC= 2.8, p&amp;lt;0.003), fructose-6-phosphate (FC=2.9, p&amp;lt;0.001) and lactate (FC= 1.7, p=0.013). Ovarian cancer cells showed significantly elevated levels of long-chain fatty acids (e.g, docosatrienoate (22:3n3) [FC= 9.06, p &amp;lt; 0.001), including those derived from the diet (linoleate [FC=2.25, p&amp;lt;0.001] and linolenate [FC=2.37, p&amp;lt;0.001]). Furthermore, significantly high levels of components needed for phospholipid biosynthetic pathway (e.g. cytidine 5′-diphosphocholine [16.86, p &amp;lt; 0.001], choline [FC = 1.5, p&amp;lt;0.001]) were seen which along with the altered lipid metabolism supports membrane biosynthesis in cancer cells. The eicosanoid metabolism pathway had significantly higher levels of pro-inflammatory compounds such as prostaglandins E2 (FC= 17.11, p&amp;lt;0.001), I2 (FC=16.35, p&amp;lt;0.001) and 6-keto prostaglandin F1-α (FC= 16.77, p&amp;lt;0.001). Interestingly, compounds best characterized only in the central nervous system, were also significantly elevated in ovarian cancer tissues. Conclusion: High grade EOC shows distinct metabolic alterations compared to normal ovarian tissues, forming the basis for targeting key metabolic pathways for biomarker and/or therapeutic approaches in ovarian cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4802. doi:1538-7445.AM2012-4802
Stat Bite Lung Cancer Rates in U. S. Men
Authors: L. G. Kessler
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Stat Bite Lung Cancer Rates in U. S. Men Get access Larry G. Kessler, Sc.D. Larry G. Kessler, Sc.D. Applied Research BranchNCI Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 4, 15 February 1995, Page 251, https://doi.org/10.1093/jnci/87.4.251 Published: 15 February 1995
OBESITY PARADOX IN PULMONARY HYPERTENSION: ANALYSIS OF THE NIH-PULMONARY HYPERTENSION REGISTRY
Authors: Vijaiganesh Nagarajan, Kenneth Bilchick, Luke Kohan, Timothy S. Welch, Andrew D. Mihalek, Jamie L.W. Kennedy, Sula Mazimba
Journal: Journal of the American College of Cardiology (2016)
Protection of committed murine haemopoietic progenitors against BCNU toxicity does not predict protection of primitive, multipotent spleen colony-forming cells – implications for chemoprotective gene therapy
Authors: N Chinnasamy, JA Rafferty, LS Lashford, D Chinnasamy, GP Margison, N Thatcher, TM Dexter, LJ Fairbairn
Journal: Leukemia (1999)
FRI0273 Plasma levels of pf-4var/cxcl4l1, a nonallelic variant of platelet factor-4 (PF-4/CXCL4), are elevated in patients with antiphospholipid syndrome (APS).
Authors: M. P. Sikara, P. G. Vlachoyiannopoulos
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Platelet derived chemokines, such as PF-4 and a recently isolated protein product of its nonallelic variant gene PF-4var, are implicated in several aspects of vascular thrombosis and inflammation. The above chemokines present only 4.3% aminoacid divergence in the mature proteins; however they exhibit distinct platelet secretion mode and function. The precise role of PF-4var regarding the haemostatic balance is not yet studied. Previous study from our group demonstrates a novel interaction between β2-glycoprotein I (β2GPI), the major autoantigen in APS, and PF-4 or PF-4var. This complex formation leads in the stabilization of β2GPI dimeric structure which facilitates the antibody recognition and platelet activation, as indicated by p38MAPK phosphorylation and thromboxane production. <h3>Objectives</h3> To determine PF-4var plasma levels in patients with APS and evaluate the correlation with clinical and laboratory parameters of the disease. <h3>Methods</h3> From 70 patients, who fulfill the revised diagnostic criteria for APS, blood samples were taken and separate samples of serum, plasma and platelets were isolated. Complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), aPTT, anti-cardiolipin (anti-CL) and anti-β2GPI antibodies were measured. A healthy control (n=20) and a disease control group (SLE, n=10) were included in the study (study in progress to increase the number of both groups). Plasma levels of PF-4var were determined using a commercially available ELISA, which absolutely discriminates PF-4var from PF-4 protein. Statistical analyses were evaluated by Mann-Whitney t-test and Kruskal-Wallis test. <h3>Results</h3> APS patients showed higher levels of PF-4var compared to healthy individuals (median 137 pg/ml; intarquartile range 66.4-200.5 pg/ml versus 79.03 [40.3-99.2] pg/ml, p=0.0052). PF-4var levels were significantly elevated in patients suffering from primary APS (PAPS) than those with APS secondary to SLE (SAPS), (197.7 [113.3-304.8] pg/ml versus 126.6 [49.94-170] pg/ml, p=0.0086). Regarding the clinical presentation of the disease, patients who experienced thrombotic events versus pregnancy morbidity or arterial versus venous thrombotic events do not show statistically significant difference in PF-4var levels. A positive correlation was also revealed between the presence of thrombocytopenia and the elongation of aPTT with the higher PF-4var levels (p= 0.0048 and p=0.0195, respectively). <h3>Conclusions</h3> Preliminary results suggest that higher PF-4var levels are present in plasma of APS patients and especially in those with PAPS and these are associated with laboratory characteristics indicative for higher risk of thrombotic complications. <b>Disclosure of Interest</b>: None Declared