tbuckley/cabot-search huggingface dataset:
Anal human papillomavirus in HIV-uninfected men who have sex with men: incidence and clearance rates, duration of infection, and risk factors
Authors: M.G. Donà, M.F. Vescio, A. Latini, A. Giglio, D. Moretto, M. Frasca, M. Benevolo, F. Rollo, M. Colafigli, A. Cristaudo, M. Giuliani
Journal: Clinical Microbiology and Infection (2016)
Alternative Donor Stem Cell Transplantation In Aplastic Anemias and Refractory Cytopenias Is Save and Feasible With T- and B-Cell Depleted Haploidentical Grafts
Authors: Tobias Feuchtinger, Heiko-Manuel Teltschik, Matthias Pfeiffer, Ingo Mueller, Andre Schrauder, Rupert Handgretinger, Peter Lang
Journal: Blood (2013)
Hemoglobin‐Conjugated Gelatin Microsphere as a Smart Oxygen Releasing Biomaterial
Authors: Antonio Paciello, Giuseppe Amalfitano, Alessandro Garziano, Francesco Urciuolo, Paolo A. Netti
Journal: Advanced Healthcare Materials (2016)

In this study, a novel micrometric biomaterial acting as a cyclic oxygen releasing system is designed. Human hemoglobin (Hb) is conjugated to the surface of gelatin microspheres (GM) to produce gelatin hemoglobin oxygen depot (G-HbOD). G-HbOD is obtained by means of two different conjugation strategies. The degree of conjugation of GM surfaces in terms of free amino groups by using HPLC is first evaluated. By following the strategy A (G-HbOD_A), Hb is conjugated to GM by means of the formation of a polyurethane linker. In the strategy B (G-HbOD_B) the conjugation occurs via amide bound formation. Physical and morphological differences between G-HbOD_A and G-HbOD_B are investigated by means of Fourier Transform Infrared Spectroscopy (FTIR), Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES), Scanning Electron Microscopy (SEM) and Atomic Force Microscopy (AFM). Differences in oxygen uptake/release kinetics are found depending on the conjugation strategy and it is proved that G-HbOD works under repeated cycles in microfluidic chip. Moreover, G-HbOD is also able to work as oxygen depot in the early stages of 3D cell cultures.
First outbreak of Crimean-Congo haemorrhagic fever in western Europe kills one man in Spain
Authors: Aser García Rada
Journal: BMJ (2016)

Crimean-Congo haemorrhagic fever has killed a 62 year old man in Spain and infected one of the nurses who treated him in the first domestically contracted outbreak of the disease in western Europe, Spanish health authorities have said.

The man, who died on 25 August in Gregorio Maranon Hospital in Madrid, contracted the disease after he was bitten by a tick while walking in the Sierra …
Author’s reply to Dean and Coakley
Authors: Ashley A Cole
Journal: BMJ (2016)

In reply to Dean and Coakley,1 2 I am familiar with the Cochrane review and also a clinical review article from The BMJ on the management of lumbar spinal stenosis.3 Both articles note that studies into the management of this condition are difficult because of its heterogeneity, the varying severity of symptoms, the failure of studies to define their conservative management, and …
Recent Data Supporting Novel Management Strategies for Patients With Multiple Myeloma
Authors: Meletios A. Dimopoulos, Efstathios Kastritis, Evangelos Terpos
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Abnormal T-cell repertoire is consistent with immune process underlying the pathogenesis of paroxysmal nocturnal hemoglobinuria
Authors: Anastasios Karadimitris, John S. Manavalan, Howard T. Thaler, Rosario Notaro, David J. Araten, Khedoudja Nafa, Irene A.G. Roberts, Marc E. Weksler, Lucio Luzzatto
Journal: Blood (2000)
The impact of direct-acting antivirals on early tumor recurrence after radiofrequency ablation in hepatitis C-related hepatocellular carcinoma
Authors: Tatsuya Minami, Ryosuke Tateishi, Ryo Nakagomi, Naoto Fujiwara, Masaya Sato, Kenichiro Enooku, Hayato Nakagawa, Yoshinari Asaoka, Yuji Kondo, Shuichiro Shiina, Kazuhiko Koike
Journal: Journal of Hepatology (2016)
Case 23-1972
Authors: Richard C. Cabot, Benjamin Castleman, Robert E. Scully, Betty U. McNeely, William H. Baker, Benjamin Castleman
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 44-year-old man was admitted to the hospital because of the radiologic finding of a mass in the lung.He had been well until 18 years previously, when pain developed in the right thigh. X-ray films disclosed a lytic lesion in the proximal portion of the right femoral shaft, and a biopsy revealed plasma-cell myeloma. No other bony lesions were demonstrated, and a test of the urine for Bence-Jones protein was negative. Radiation treatment was begun, but a pathologic fracture occurred at the site of the lesion; the lesion was curetted, and a Jewett nail and plate . . .
Mirna Profiling Reveals Specific Patterns for Normal B Cell Subsets and B Cell Lymphomas with a Unique Burkitt Lymphoma Profile
Authors: Jan-Lukas Robertus, Geert Harms, Rogier Reijmers, Steven Pals, Yolanthe Swart, Klaas Kok, Stefano Rosati, Ed Schuuring, Gustaaf van Imhoff, Philip Kluin, Anke van den Berg
Journal: Blood (2008)
Graphene quantum dots conjugated neuroprotective peptide improve learning and memory capability
Authors: Songhua Xiao, Daoyou Zhou, Ping Luan, Beibei Gu, Longbao Feng, Shengnuo Fan, Wang Liao, Wenli Fang, Lianhong Yang, Enxiang Tao, Rui Guo, Jun Liu
Journal: Biomaterials (2016)
Mortality in hepatitis C patients who achieve a sustained viral response compared to the general population
Authors: Hamish Innes, Scott McDonald, Peter Hayes, John F. Dillon, Sam Allen, David Goldberg, Peter R. Mills, Stephen T. Barclay, David Wilks, Heather Valerio, Ray Fox, Diptendu Bhattacharyya, Nicholas Kennedy, Judith Morris, Andrew Fraser, Adrian Stanley, Peter Bramley, Sharon J. Hutchinson
Journal: Journal of Hepatology (2016)
A validation of the National Early Warning Score to predict outcome in patients with COPD exacerbation
Authors: Luke E Hodgson, Borislav D Dimitrov, Jo Congleton, Richard Venn, Lui G Forni, Paul J Roderick
Journal: Thorax (2016)

<h3>Background</h3> The National Early Warning Score (NEWS), proposed as a standardised track and trigger system, may perform less well in acute exacerbation of COPD (AECOPD). This study externally validated NEWS and modifications (Chronic Respiratory Early Warning Score (CREWS) and Salford-NEWS) in AECOPD. <h3>Methods</h3> An observational cohort study (2012–2014, two UK acute medical units (AMUs)), compared AECOPD (2361 admissions, 942 individuals, International Statistical Classification of Diseases and Related Health Problems-10 J40–J44 codes) with AMU patients (37 109 admissions, 20 415 individuals). <h3>Outcome</h3> In-hospital mortality prediction was done by admission NEWS, CREWS and Salford-NEWS assessed by discrimination (area under receiver operating characteristic curves (AUROCs)) and calibration (plots and Hosmer-Lemeshow (H-L) goodness-of-fit). <h3>Results</h3> Median admission NEWS in AECOPD was 4 (IQR 2–6) versus 1 (0–3) in AMUs (p≤0.001), despite mortality of 4.5% in both. AECOPD AUROCs were NEWS 0.74 (95% CI 0.66 to 0.82), CREWS 0.72 (0.63 to 0.80) and Salford-NEWS 0.62 (0.53 to 0.70). AMU NEWS AUROC was 0.77 (0.75 to 0.78). At threshold NEWS=5 for AECOPD (44% of admissions), positive predictive value (PPV) of death was 8% (5 to 11) and negative predictive value (NPV) was 98% (97 to 99) versus AMU patients PPV of 17% (16 to 19) and NPV of 97% (97 to 97). For NEWS in AECOPD H-L p value=0.202. <h3>Conclusion</h3> This first validation of the NEWS in AECOPD found modest discrimination to predict mortality. Lower specificity of NEWS in patients with AECOPD versus other AMU patients reflects acute and chronic respiratory physiological disturbance (including hypoxia), with resultant low PPV at NEWS=5. CREWS and Salford-NEWS, adjusting for chronic hypoxia, increased the specificity and PPV but there was no gain in discrimination.
Subgroups of Diffuse Large B-Cell Lymphoma (DLBCL) with Different Genomic Lesions and Clinical Course During Treatment with R-CHOP.
Authors: Marta Scandurra, Michael Mian, Cassio P. De Campos, Paola M.V. Rancoita, Timothy C. Greiner, Wing C. Chan, Julie M. Vose, Giorgio Inghirami, Annalisa Chiappella, Luca Baldini, Maurilio Ponzoni, Andres JM Ferreri, Santiago Montes Moreno, Miguel A. Piris, Silvia Franceschetti, Gianluca Gaidano, Fabio Facchetti, Alessandra Tucci, Thierry Lazure, Olivier Lambotte, Silvia Uccella, Maria Grazia Tibiletti, Graziella Pinotti, Giancarlo Pruneri, Giovanni Martinelli, Josep F. Nomdedeu, Ekaterina Chigrinova, Andrea Rinaldi, Emanuele Zucca, Ivo Kwee, Francesco Bertoni
Journal: Blood (2009)
Value, Access, and Cost of Cancer Care Delivery at Academic Cancer Centers
Authors: Elizabeth A. Nardi, Julie A. Wolfson, Steven T. Rosen, Robert B. Diasio, Stanton L. Gerson, Barbara A. Parker, Joseph C. Alvarnas, Harlan A. Levine, Yuman Fong, Dennis D. Weisenburger, C. Lyn Fitzgerald, Maggie Egan, Sharon Stranford, Robert W. Carlson, Edward J. Benz
Journal: Journal of the National Comprehensive Cancer Network (2016)

Key challenges facing the oncology community today include access to appropriate, high quality, patient-centered cancer care; defining and delivering high-value care; and rising costs. The National Comprehensive Cancer Network convened a Work Group composed of NCCN Member Institution cancer center directors and their delegates to examine the challenges of access, high costs, and defining and demonstrating value at the academic cancer centers. The group identified key challenges and possible solutions to addressing these issues. The findings and recommendations of the Work Group were then presented at the Value, Access, and Cost of Cancer Care Policy Summit in September 2015 and multi-stakeholder roundtable panel discussions explored these findings and recommendations along with additional items.
Putting Parity into Practice — Integrating Opioid-Use Disorder Treatment into the Hospital Setting
Authors: Laura Fanucchi, Michelle R. Lofwall
Journal: New England Journal of Medicine (2016)

U.S. hospitalizations for severe infections associated with illicit opioid use have doubled over the past decade and are often prolonged and resource-intensive, but medication-assisted treatment for opioid use disorder can be integrated into hospital care.
Treatment of Medically Refractory Essential Tremor
Authors: Elan D Louis
Journal: New England Journal of Medicine (2016)

Essential tremor is among the most prevalent neurologic diseases, estimated to affect approximately 7 million persons in the United States alone.1 The primary feature is kinetic tremor, affecting the hands and arms, although tremor may take on other forms (i.e., postural, intentional, and rest tremors), may affect other body regions (i.e., head and voice), and may be accompanied by additional motor features (e.g., gait ataxia) and nonmotor features. Emerging evidence suggests that the disease may be neurodegenerative.2,3 As with other such diseases, effective pharmacotherapies for essential tremor have been elusive. There are few available medications, with the mainstays of . . .
The role of health care professionals in smoking cessation among patients with pulmonary diseases: an Italian multicentric survey
Authors: S. Demichelis, S.G. Rapetti, D. Galetta, A. Bruno, E. Bria, S. Pilotto, G. Valmadre, D. Ricci, M. Gianetta, S. Vallone, M.V. Pacchiana, S. Novello
Journal: Annals of Oncology (2015)
Study of intra-abdominal hypertension prevalence and awareness level among experienced ICU medical staff
Authors: Hua-yu Zhang, Dong Liu, Hao Tang, Shi-jin Sun, Shan-mu Ai, Wen-qun Yang, Dong-po Jiang, Lian-yang Zhang
Journal: Military Medical Research (2016)

Intra-abdominal hypertension (IAH) is a disease with high morbidity and mortality among critically ill patients. The study's objectives were to explore the prevalence of IAH and physicians' awareness of the 2013 World Society of Abdominal Compartment Syndrome (WSACS) guidelines in Chinese intensive care units (ICUs).A cross-sectional study of four ICUs in Southwestern China was conducted from June 17 to August 2, 2014. Adult patients admitted to the ICU for more than 24 h, with bladder catheter but without obvious intravesical pressure (IVP) measurement contraindications, were recruited. Intensivists with more than 5 years of ICU working experience were also recruited. Epidemiological information, potential IAH risk factors, IVP measurements and questionnaire results were recorded.Forty-one patients were selected. Fifteen (36.59 %) had IVP ≥ 12 mmHg. SOFA (Sequential Organ Failure Assessment) hepatic and neurological sub-scores were utilized as independent predictors for IAH via logistic backward analysis. Thirty-seven intensivists participated in the survey (response rate: 80.43 %). The average score of each center was less than 35 points. All physicians believed the IAH prevalence in their departments was no more than 20.00 %. A significant negative correlation was observed between the intensivists' awareness of the 2013 WSACS guidelines and the IAH prevalence in each center (r = -0.975, P = 0.025).The prevalence and independent predictors of IAH among the surveyed population are similar to the reports in the literature. Intensivists generally have a low awareness of the 2013 WSACS guidelines. A systematic guideline training program is vital for improving the efficiency of the diagnosis and treatment of IAH.
Magnetically guided delivery of DHA and Fe ions for enhanced cancer therapy based on pH-responsive degradation of DHA-loaded Fe 3 O 4 @C@MIL-100(Fe) nanoparticles
Authors: Dongdong Wang, Jiajia Zhou, Ruhui Chen, Ruohong Shi, Guoliang Xia, Shu Zhou, Zhenbang Liu, NianQing Zhang, Haibao Wang, Zhen Guo, Qianwang Chen
Journal: Biomaterials (2016)
Pathological characteristics and prognosis of a cohort of 74 patients (pts) with breast cancer (BC) with neoplastic meningitis (NM).
Authors: N. Kotecki, E. Le Rhun, M. Baranzelli, M. Faivre-Pierret, F. Zairi, F. Dubois, P. Devos, J. Bonneterre
Journal: Journal of Clinical Oncology (2010)

1123 Background: Around 5% of pts with breast cancer develop NM, which have a median overall survival (OS) of 5 months if treated and of 5 weeks if untreated. Pathological risk factors of NM are poorly known. Methods: 74 consecutive female BC pts diagnosed with NM were prospectively followed between 2007 and 2009. The objective was to report pathological characteristics and prognostic factors of these patients. Usual statistical analyses were performed (Chi square, Fisher exact test, Wilcoxon test, Kaplan Meier, Log-rank). Results: At NM diagnosis, CSF cytology and cerebrospinal MRI were abnormal in respectively 66% and 92% of the pts. Median age at NM diagnosis was 48 years. Median time between BC and NM was 40 months. Most BC were invasive ductal carcinomas (72%), with HPG grade 2 (58%) (differentiation 3 in 71%, anisonucleosis 3 in 47% and mitosis 1 in 54%). Estrogen and progesterone receptors (ER/PR) were detected in respectively 62 and 37%, a HER2 hyperexpression in 26% of the cases. 25% were triple negative. Vascular invasion was observed in 53%. 61% of the pts were N+ and 29% were metastatic upfront. At BC diagnosis, 79% received chemotherapy (CT). The most common first metastatic site was bone (48%). Brain and NM were the first metastatic site in respectively in 18% and 14%. At NM diagnosis, bone, brain, liver and lung metastases were present in respectively 64%, 48 %, 46% and 29% of the pts. 89% received intrathecal(IT) CT, which was associated with systemic treatment in 42%. Median OS of all pts was 3.3 months (0-22). Median OS of pts with IT CT was 5.3 months (0.5-22). The time between BC diagnosis and NM was significantly correlated with CT at BC diagnosis (p=0.004), T status (p=0.02), poor differentiation (p=0.03), ER negativity (p=0.01), triple negative status (p=0.04), NM (p=0.002) and non bony (p=0.02) as the first metastatic site or lung metastase at the time of NM diagnosis (p=0.003). OS was significantly correlated with mitosis grade (p=0.03), brain metastases at NM diagnosis (p=0.04). Conclusions: According to this study, the main risk factors of NM are lobular, ER negative, HER2-positive or triple negative, proliferative, poorly differentiated tumors. No significant financial relationships to disclose.
Do ω-3 Fatty Acids Regulate Cerebral β Amyloid?
Authors: Joseph F. Quinn
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton
Authors: Erin Janssen, Mira Tohme, Mona Hedayat, Marion Leick, Sudha Kumari, Narayanaswamy Ramesh, Michel J. Massaad, Sumana Ullas, Veronica Azcutia, Christopher C. Goodnow, Katrina L. Randall, Qi Qiao, Hao Wu, Waleed Al-Herz, Dianne Cox, John Hartwig, Darrell J. Irvine, Francis W. Luscinskas, Raif S. Geha
Journal: Journal of Clinical Investigation (2016)

Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor-driven (TCR-driven) actin polymerization. The clinical phenotype of WAS includes susceptibility to infection, allergy, autoimmunity, and malignancy and overlaps with the symptoms of dedicator of cytokinesis 8 (DOCK8) deficiency, suggesting that the 2 syndromes share common pathogenic mechanisms. Here, we demonstrated that the WASp-interacting protein (WIP) bridges DOCK8 to WASp and actin in T cells. We determined that the guanine nucleotide exchange factor activity of DOCK8 is essential for the integrity of the subcortical actin cytoskeleton as well as for TCR-driven WASp activation, F-actin assembly, immune synapse formation, actin foci formation, mechanotransduction, T cell transendothelial migration, and homing to lymph nodes, all of which also depend on WASp. These results indicate that DOCK8 and WASp are in the same signaling pathway that links TCRs to the actin cytoskeleton in TCR-driven actin assembly. Further, they provide an explanation for similarities in the clinical phenotypes of WAS and DOCK8 deficiency.
Government’s own documents question “seven day NHS” feasibility
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The government has been heavily criticised and asked to justify its policy of introducing a “truly” seven day a week NHS service after a leak of its own official documents questioning whether the policy is achievable.

A leaked “risk register” and other documents assessing the policy, produced for ministers by civil servants at the Department of Health, have been seen by the Guardian newspaper,1 as well as Channel 4. A risk register details all potential issues under a worst case scenario to help the government develop robust plans.

The documents reportedly say that the NHS does not have enough staff or financial resources to deliver the government’s promised “truly seven day NHS” by 2020—a key Conservative pre-election pledge.

The …
Survivin and CrkL expression in erlotinib-treated non-small cell lung cancer (NSCLC) patients (p) with EGFR mutations.
Authors: M. A. Molina, S. Simonetti, V. Quiroga, S. Viteri, R. G. Campelo, J. Sanchez, S. Benlloch, E. Aldeguer, M. Taron, R. Rosell
Journal: Journal of Clinical Oncology (2010)

e18063 Background: Survivin inhibits activation of caspas es, and its overexpr ession can lead to resistance to apoptotic stimuli. Enhanced survivin expression has been shown to be related to IGF-1R activity. CrkL is a 39-kDa tyrosine-phosphorylated adaptor protein that is involved in leukemia cell signalling and is an important substrate of Bcr-Abl. Methods: Survivin and CrkL protein expression were ass essed by immunohistochemical (IHC) staining in original pretreatment tumor biopsies of 126 NSCLC p with EGFR mutations, in whom IGF-1R expr ession had previously been examined. IHC was evaluated semiquantitatively and scored according to the percentage of cells showing distinct nuclear and/or cytoplasmic reaction and the intensity of IHC. Tumors with a score of 0 or 1 were defined as negative and those with a score of 2 or 3 were defined as positive. IHC intensity was correlated with outcome to erlotinib. Results: There was no correlation between the expression of survivin and CrkL (p = 0.16). A correlation was observed between survivin and IGF-1R mRNA levels (r = 0.12; p = 0.005). No differences were observed in the expression of the two proteins according to gender, smoking history, PS, type of EGFR mutation, metastatic site, or other clinical characteristics. Overall response rate (RR) was 70%, progr ession-free survival (PFS) was 14 months (m), and median survival (MS) was 27 m. No differenc es in RR were observed according to the expression of either of the proteins. PFS for the 17 p with negative survivin was 24 m vs 14 m for 109 p with positive survivin (p = 0.11). MS was 36 m for p with negative survivin and 27 m for those with positive survivin (p = 0.004). No differences in PFS or MS were observed according to CrkL expr ession. Conclusions: Negative survivin protein expression is observed in a small number of patients with EGFR mutations and confers improved survival. No significant financial relationships to disclose.