Annals for Hospitalists Inpatient Notes - Oral Anticoagulation for the Hospitalist—Expanded Choices Improve Patient-Centered Care
Authors: Geoffrey D. Barnes, David Paje
Journal: Annals of Internal Medicine (2016)

Web Exclusives20 September 2016Annals for Hospitalists Inpatient Notes - Oral Anticoagulation for the Hospitalist—Expanded Choices Improve Patient-Centered CareGeoffrey D. Barnes, MD, MSc and David Paje, MDGeoffrey D. Barnes, MD, MScFrom the University of Michigan Medical School and University of Michigan Health System, Ann Arbor, Michigan.Search for more papers by this author and David Paje, MDFrom the University of Michigan Medical School and University of Michigan Health System, Ann Arbor, Michigan.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-1806 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Initiation of anticoagulant medications is among the most common and critical tasks hospitalists perform. Appropriate anticoagulation entails thoughtful consideration of individual circumstances, including the competing risks for thrombosis and bleeding.For more than half a century, vitamin K antagonists (VKAs), such as warfarin, were the only oral agents available for long-term anticoagulation. Their serendipitous discovery from plant products predated the recognition of vitamin K itself and the understanding of its role in coagulation. It took decades to fully realize the therapeutic potential of VKAs. It was not until the late 1990s that standardized protocols and nomograms along with involvement of ...References1. Barnes GD, Ageno W, Ansell J, Kaatz S. Recommendation on the nomenclature for oral anticoagulants: communication from the SSC of the ISTH: reply [Letter]. J Thromb Haemost. 2015;13:2132-3. [PMID: 26340598] doi:10.1111/jth.13136 CrossrefMedlineGoogle Scholar2. Ruff CT, Giugliano RP, Braunwald E, Hoffman EB, Deenadayalu N, Ezekowitz MD, et al. Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials. Lancet. 2014;383:955-62. [PMID: 24315724] doi:10.1016/S0140-6736(13)62343-0 CrossrefMedlineGoogle Scholar3. van Es N, Coppens M, Schulman S, Middeldorp S, Büller HR. Direct oral anticoagulants compared with vitamin K antagonists for acute venous thromboembolism: evidence from phase 3 trials. Blood. 2014;124:1968-75. [PMID: 24963045] doi:10.1182/blood-2014-04-571232 CrossrefMedlineGoogle Scholar4. Barnes GD, Lucas E, Alexander GC, Goldberger ZD. National trends in ambulatory oral anticoagulant use. Am J Med. 2015;128:1300-5. [PMID: 26144101] doi:10.1016/j.amjmed.2015.05.044 CrossrefMedlineGoogle Scholar5. Barnes GD, Nallamothu BK, Sales AE, Froehlich JB. Reimagining anticoagulation clinics in the era of direct oral anticoagulants. Circ Cardiovasc Qual Outcomes. 2016;9:182-5. [PMID: 26933047] doi:10.1161/CIRCOUTCOMES.115.002366 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From the University of Michigan Medical School and University of Michigan Health System, Ann Arbor, Michigan.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-1806.Corresponding Author: Geoffrey D. Barnes, MD, Department of Internal Medicine, Frankel Cardiovascular Center and Institute for Healthcare Policy and Innovation, University of Michigan Medical School, 2800 Plymouth Road, Building 14, Room G101, Ann Arbor, MI 48108; e-mail, [email protected]edu.Current Author Addresses: Dr. Barnes: Department of Internal Medicine, Frankel Cardiovascular Center and Institute for Healthcare Policy and Innovation, University of Michigan Medical School, 2800 Plymouth Road, Building 14, Room G101, Ann Arbor, MI 48108.Dr. Paje: University of Michigan, 1500 East Medical Center Drive, SPC 5317, Ann Arbor, MI 48109. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAnnals for Hospitalists - 20 September 2016 David H. Wesorick and Vineet Chopra Metrics 20 September 2016Volume 165, Issue 6Page: HO2-HO3KeywordsAnticoagulantsDisclosureDrugsHealth care policyHemorrhageHospitalistsPopulation statisticsSafetyThrombosisVitamin K ePublished: 20 September 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...