tbuckley/cabot-search huggingface dataset:
Fractionation Studies on the Tumor-Necrotizing Agent from <italic>Serratia marcescens</italic> (Shear's Polysaccharide)<xref ref-type="fn" rid="fn1">2</xref>
Authors: Paul Rathgeb, Ph.D., Bengt Sylvén, M.D.
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Fractionation Studies on the Tumor-Necrotizing Agent from Serratia marcescens (Shear's Polysaccharide) Get access Paul Rathgeb, Ph.D., Paul Rathgeb, Ph.D. Cancer Research Division of Radiumhemmet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar Bengt Sylvén, M.D. Bengt Sylvén, M.D. Cancer Research Division of Radiumhemmet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 5, April 1954, Pages 1099–1108, https://doi.org/10.1093/jnci/14.5.1099 Published: 01 April 1954 Article history Received: 21 August 1953 Published: 01 April 1954
Combination of the novel histone deacetylase inhibitor YCW1 and radiation induces autophagic cell death through the downregulation of BNIP3 in triple-negative breast cancer cells in vitro and in an orthotopic mouse model
Authors: Hui-Wen Chiu, Ya-Ling Yeh, Yi-Ching Wang, Wei-Jan Huang, Sheng-Yow Ho, Pinpin Lin, Ying-Jan Wang
Journal: Molecular Cancer (2016)

Triple-negative breast cancer (TNBC) is the most aggressive and invasive of the breast cancer subtypes. TNBC is a challenging disease that lacks targets for treatment. Histone deacetylase inhibitors (HDACi) are a group of targeted anticancer agents that enhance radiosensitivity. Bcl-2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) is a member of the Bcl-2 subfamily. BNIP3 is not found in normal breast tissue but is up-regulated in breast cancer. In the present study, we investigated the anti-cancer effects of a newly developed HDACi, YCW1, combined with ionizing radiation (IR) in TNBC in vitro and in an orthotopic mouse model. Furthermore, we examined the relationship between autophagy and BNIP3. Trypan blue exclusion was used to investigate the viability of 4 T1 (a mouse TNBC cell line) and MDA-MB-231 cells (a human TNBC cell line) following combined YCW1 and IR treatment. Flow cytometry was used to determine apoptosis and autophagy. The expression levels of BNIP3, endoplasmic reticulum (ER) stress- and autophagic-related proteins were measured using western blot analysis. An orthotopic mouse model was used to investigate the in vivo effects of YCW1 and IR alone and in combination. Tumor volumes were monitored using a bioluminescence-based IVIS Imaging System 200. We found that YCW1 significantly enhanced toxicity in 4 T1 cells compared with suberoylanilide hydroxamic acid (SAHA), which was the first HDACi approved by the Food and Drug Administration for clinical use in cancer patients. The combined treatment of YCW1 and IR enhanced cytotoxicity by inducing ER stress and increasing autophagy induction. Additionally, the combined treatment caused autophagic flux and autophagic cell death. Furthermore, the expression level of BNIP3 was significantly decreased in cells following combined treatment. The downregulation of BNIP3 led to a significant increase in autophagy and cytotoxicity. The combined anti-tumor effects of YCW1 and IR were also observed in an orthotopic mouse model; combination therapy resulted in a significant increase in autophagy and decreased tumor tissue expression of BNIP3 in the tumor tissue. These data support the possibility of using a combination of HDACi and IR in the treatment of TNBC. Moreover, BNIP3 may be a potential target protein for TNBC treatment.
Dealing with Ebola virus disease in Spain: epidemiological inquiries received by the Department of Public Health Alerts, April to December 2014
Authors: Vendula Blaya-Nováková, María Ángeles Lópaz-Pérez, Isabel Méndez-Navas, María Felicitas Domínguez-Berjón, Jenaro Astray-Mochales
Journal: Eurosurveillance (2015)

We describe the inquiries regarding Ebola virus disease (EVD) received by the Department of Public Health Alerts of the Community of Madrid between April and December 2014. A total of 242 inquiries were received. Consultations were initiated most frequently by hospital clinicians (59 inquiries, 24%), private citizens (57 inquiries, 24%) and primary care physicians (53 inquiries, 22%). The most frequent topic of inquiry was possible EVD in a patient (215 inquiries, 89%). Among these, 31 persons (14%) presented both EVD-compatible symptoms and epidemiological risk factors, and 11 persons (5%) fulfilled the criteria for a person under investigation. Recent travel abroad was reported in 96 persons (45%), but only 32 (15%) had travelled to an EVD-affected area. Two high-risk and one low-risk contact were identified through these inquiries. Low specificity of the EVD symptoms led to many difficulties in protocol application. Ineffective communication with healthcare professionals and unfamiliarity with the EVD protocols caused many case classification errors. A rapid consultation service by telephone is essential for providing qualified advice during emergencies. Our experience may help other countries dimension their activities and resources for managing similar exceptional outbreaks in the future.
Abstract 3031: Repeat Revascularisation following Multivessel Sirolimus-eluting Stent Implantation: Indications and Long-term Follow-up From the Arterial Revascularisation Therapies Study Part 2 (ARTS-II)
Authors: Neville Kukreja, Patrick Serruys, Steve Ramcharitar, Shuzou Tanimoto, Yoshinobu Onuma, Bernard de Bruyne, Antonio Colombo, Carlos Macaya, Gert Richardt, Jean Fajadet, Christian Hamm, Monique Schuijer, Magdaleen Pieters, Hans-Peter Stoll
Journal: Circulation (2008)

Objectives: Although coronary-artery bypass grafting (CABG) has been considered the gold standard of treatment for multivessel coronary artery disease, percutaneous coronary intervention (PCI) with drug-eluting stents (DES) may be an alternative: the ARTS-II trial found that after 3 years, the major benefit of CABG was a decreased need for repeat revascularization. We reviewed the angiographic findings in all patients from ARTS-II who required repeat revascularization to investigate their prognosis and to establish the reasons for repeat revascularization in these high risk complex patients, including the relative contributions of procedural complications, neointimal hyperplasia, stent thrombosis, geographical miss and disease progression. Methods: There was no routine angiographic follow-up in ARTS-II. All intercurrent angiograms within 3 years were reviewed. Patients requiring CABG due to index procedural complications or procedural failure were excluded (n = 8). The angiographic indications for repeat revascularization were categorized into target lesion revascularization (TLR), target vessel-non target lesion revascularization (TV-nonTLR) or non-target vessel revascularization (non-TVR). Patients undergoing TLR were further categorized into instent restenosis (ISR) according to the Mehran classification, stent edge restenosis (SER) or definite stent thrombosis (ST). Findings: Within 3 years of the initial treatment, 81/607 patients required 103 repeat revascularizations to treat 150 lesions. These repeat revascularizations were classified as TLR in 74% of lesions, TV-nonTLR in 22% and non-TVR in 4%. The cases of TLR were due to ISR in 59%, SER in 25% and ST in 17%. The majority of ISR cases were Mehran Class IC (focal, body). ISR accounted for 42% of all repeat revascularizations, whilst ST accounted for 11%. Conclusion: Repeat revascularization was due to ISR or ST in approximately half of the lesions; the remainder were due to either incomplete lesion coverage or disease progression. Hard clinical endpoint outcomes of patients stratified by the type of repeat revascularization will be presented at the meeting.
Chemotherapy plus Surgery versus Surgery Alone in Non-Small-Cell Lung Cancer
Authors: V Cocquyt, W De Neve, S J Van Belle
Journal: New England Journal of Medicine (1994)

To the Editor: We are concerned about several aspects of the study by Rosell et al. (Jan. 20 issue)1. The title is incorrect and misleading: the trial did not compare preoperative chemotherapy plus surgery with surgery alone; the trial compared preoperative chemotherapy plus surgery plus radiotherapy with surgery plus radiotherapy. The rates of survival and disease-free survival were extremely poor in the surgery-plus-radiotherapy group. These rates would be expected among patients with metastatic non-small-cell lung cancer but are inferior to what would be expected in patients with resectable stage III disease. In several randomized trials, reviewed by Van Houtte,. © 1994, Massachusetts Medical Society. All rights reserved.
Responding to a Request for Physician-Assisted Death
Authors: Mitchel L. Galishoff
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Rolitetracycline An Antibiotic for Parenteral Use
Authors: L SMITH
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A randomized, double-blind, placebo-controlled trial of methylphenidate for attentional problems in survivors of childhood cancer
Authors: R. K. Mulhern, R. Khan, S. Kaplan, X. Xiong, S. Wu, S. Helton, R. Brown, M. Bonner, R. Christensen, W. Reddick
Journal: Journal of Clinical Oncology (2004)

8510 Background: Children surviving acute lymphoblastic leukemia (ALL) and malignant brain tumors (BT) have a higher incidence of attention and learning problems in school than their healthy peers. Our preliminary data suggested that attention deficits among survivors may acutely respond to methylphenidate (MPH; J Clin Oncol 19:1802–8, 2001) but no similar data are available from the school. Methods: We screened 343 long-term survivors of ALL and BT to identify those with attentional deficits on a computer-administered continuous performance test, attentional symptoms endorsed on parent or teacher report, and academic achievement deficits. Of 74 with the identified phenotype, 54 (30 ALL, 24 BT) completed a randomized, double-blind, three-week home cross-over trial of Placebo (P; b.i.d.), low dose MPH (LD; 0.3 mg/kg; maximum dose 10 mg b.i.d.), and moderate dose MPH (MD; 0.6 mg/kg; maximum dose 20 mg b.i.d.). The primary endpoints were weekly teacher reports. Results: The 30 male and 24 female patients ranged from 0.54 to 12.57 (M=5.25) years of age at diagnosis and 6.83 to 17.49 (M=11.63) years of age at participation. Comparisons of teacher reports on the Cognitive/Inattention, Hyperactive, and ADHD Index scales are shown below. Significant improvement (*P<0.01) with LD was seen on all 3 outcomes and with MD on the ADHD Index. No significant advantage of MD over LD was observed. Conclusions: Short-term treatment with low-dose MPH can reduce attentional problems among survivors of childhood ALL and BT. Forty-five of the 54 (83%) patients showed a positive response to MPH and continue on medication. Long-term follow-up planned at 12 months will reveal which subsets of patients are more likely to benefit from MPH. No significant financial relationships to disclose.
Carcinogenic Action of Quinoxaline 1,4-Dioxide in Rats
Authors: Mary J. Tucker
Journal: JNCI Journal of the National Cancer Institute (1975)

Quinoxaline 1,4-dioxide was fed to 400 rats at levels of 10 mg or 1 mg/kg body weight for 18 months. It produced a high incidence of nasal and liver tumors only in the group fed 10 mg/kg. Of diverse histologies, the nasal tumors included anaplastic carcinomas, adenocarcinomas, squamous cell carcinomas, neuroepitheliomas, basal cell carcinomas, and a single fibrosarcoma. The nasal epithelium not involved in the neoplastic process showed dysplasia and hyperplasia.
In Defense of Off-label Prescribing
Authors: David L. Keller
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
The Stars of Hospital Care: Useful or a Distraction?
Authors: Ashish K. Jha
Journal: JAMA (2016)

Public reporting of the quality of care delivered by physicians, hospitals, and other health care organizations has been around for a while. Some of the earliest efforts began in the 1990s, when the New York State Department of Health began reporting risk-adjusted mortality rates for surgeons performing cardiac surgery in that state (http://bit.ly/241M0FX). The early reports could be obtained by mailing a request to the Department of Health, which would send along a paper copy of the latest data.
West Nile virus circulation in south-eastern Romania, 2011 to 2013
Authors: S Dinu, A I Cotar, I R Pănculescu-Gătej, E Fălcuţă, F L Prioteasa, A Sîrbu, G Oprişan, D Bădescu, P Reiter, C S Ceianu
Journal: Eurosurveillance (2015)

Lineage 2 West Nile virus (WNV), previously found only in sub-Saharan Africa and Madagascar, was identified in Hungary in 2004 and has rapidly expanded in Europe in the past decade. Following a significant outbreak of West Nile fever with neurological cases caused by lineage 1 WNV in Romania in 1996, scattered cases have been recorded in the south-east of the country in each transmission season. Another outbreak, affecting a larger area and caused by lineage 2 WNV, was recorded in 2010. We analysed human sera from neuroinvasive West Nile fever cases and mosquitoes, sampled in south-eastern Romania between 2011 and 2013, for the presence of WNV genome, and obtained partial NS5 and envelope glycoprotein sequences. Human- and mosquito-derived WNV sequences were highly similar (99%) to Volgograd 2007 lineage 2 WNV and differed from isolates previously detected in central and southern Europe. WNV was detected in one pool of Culex pipiens s.l. males, documenting vertical transmission. Lineage 4 WNV, of unknown pathogenicity to mammals, was found in the amphibian-feeding mosquito Uranotaenia unguiculata from the Danube Delta. Our results present molecular evidence for the maintenance of the same isolates of Volgograd 2007-like lineage 2 WNV in south-eastern Romania between 2011 and 2013.
Toward empathy: the uses of wonder
Authors: A Margulies
Journal: American Journal of Psychiatry (1984)

How does one begin to approximate the inner experience of another? Empathic exploration demands of the investigator the creative capacity to suspend closure. The founders of phenomenology and psychoanalysis developed methods to facilitate a process of not-concluding, ways of keeping the mind open to new possibilities. Moreover, Husserl's phenomenological reduction and Freud's basic rule of free association bear striking affinities to Keats's formulation of the nature of artistic observation. Keats's quest for the heart of experience illuminates a path through imagination and toward empathy.
Effects of Adrenocorticotropin and Insulin on Carcinogenesis in Hypophysectomized Rats&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: B G DODGE, M A O'NEAL, J P CHANG, A C GRIFFIN
Journal: JNCI Journal of the National Cancer Institute (1961)

The administration of adrenocorticotropin and insulin to hypophysectomized rats fed 0.06 percent 3′-methyl-4-dimethylaminoazobenzene resulted in the highest incidence of liver tumors yet observed in the study of the effects on carcinogenesis of hormone replacement after hypophysectomy. The gross and histological precancerous changes observed in these animals appeared similar to those occurring in intact animals, which indicates that administration of the hormones had restored the same sequence that produces liver cancer in the intact rat. The liver concentrations of deoxyribonucleic acid, ribonucleic acid and riboflavine were also determined. In contrast to rather definite patterns observed in intact rats fed diets containing the carcinogen, there were no consistent or predictable changes observed in the livers of the hypophysectomized rats treated with adrenocorticotropin and insulin. The relative importance of the pituitary-gland in cancer induction by fluorenamines and azo dyes is discussed.
Conversion of 3β-Hydroxypregn-5-en-20-one to Progesterone by Transplantable Choriocarcinoma in Rats2
Authors: Makoto Miyamoto, Toru Sugaya, Keishi Matsumoto
Journal: JNCI Journal of the National Cancer Institute (1974)

A transplantable tumor was induced by 7,12-dimethylbenz[a]anthracene in the uterus of a rat from which a fetus had been removed. Some rat tissues were incubated with 14C-3β-hydroxypregn-5-en-20-one in organ culture. 14C-progesterone was formed in the tumor and placenta as well as in the testes, ovaries, and adrenals, but none (or little) could be found in the liver, spleen, kidneys, and muscle. In addition, radioactive testosterone, 20α-hydroxypregn-4-en-3-one, and corticosterone were formed by the testes, ovaries, and adrenals, respectively. The data supported our morphologic finding that the tumor seemed to be derived from chorionic cells.
THU0611-HPR Male Chronic Widespread Pain – Effects of Exercise. a Pilot Study
Authors: A. Ericsson, T. Bremell, Å. Cider, K. Mannerkorpi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Chronic Widespread Pain (CWP) is defined as pain in the right and left side of the body, above and below the waist combined with axial pain, for at least 3 months. The prevalence of CWP in general populations is in men between 3% and 9% and in women between 6.5% and 16%. Gender has been suggested to play a role in how patients with CWP respond to pain management programs. There is limited knowledge about the effects of exercise in men with CWP. <h3>Objectives</h3> To investigate the effects of resistance exercise (RE) on land compared to aerobic pool exercise (PE) in men with CWP. <h3>Methods</h3> Thirty-four men with CWP, mean age 49 (SD 8, range 26-59) years were randomized to 12 weeks of standardised pool exercise or land-based resistance exercise. The primary outcome was the Multidimensional Fatigue Inventory (MFI-20). Depression, anxiety, isometric force, pain and health related quality of life were also assessed. <h3>Results</h3> No significant difference was found for change in MFI-20 between the two exercise groups. RE improved isometric force in right shoulder abduction (RE: Δ2.2 SD 1.5 N, PE: Δ0.6 SD 1.2 N, p=0.009), right knee flexion (RE: Δ50, SD 50 N, PE: Δ-17, SD 71 N, p=0.003) and left knee flexion (RE: Δ33 SD 39, PE: Δ-9 SD 52 N, p=0.017) as compared to pool exercise. The drop-out rate was 29% in the RE group and 18% in the PE group. Within-group analyses showed improvement in the resistance exercise group for MFI General fatigue (p=0.040) and isometric force (p=0.003→0.015) at 12 weeks after baseline. In the pool exercise group improvement was found for MFI Physical fatigue (p=0.044), MFI Reduced motivation (p=0.021), anxiety (p=0.028) and physical component of health related quality of life (p=0.006). Both exercise groups reported fewer pain localizations at post-test. (p=0.033 and p=0.022). <h3>Conclusions</h3> A 12-week resistance exercise program improved isometric strength, when compared to a 12-week pool exercise program. The pool exercise group improved anxiety and health related quality of life over time. Both groups improved in fatigue and distribution of pain. Aerobic and resistance exercise appear to improve different aspects of health and the patients9 goals and preferences should guide the choice of treatment. Further exercise studies with larger groups are needed to gain more knowledge about differences in outcomes in men with CWP. <h3>Disclosure of Interest</h3> None declared