tbuckley/cabot-search huggingface dataset:
Lack of a chemobrain effect for adjuvant FOLFOX chemotherapy in colon cancer patients: A pilot study.
Authors: Alberto Zaniboni, Federica Andreis, Marco Ferri, Maria Mazzocchi, Fausto Meriggi, Anna Rizzi, Luigina Rota, Brunella Di Biasi, Chiara Abeni, Claudio Codignola, Renzo Rozzini
Journal: Journal of Clinical Oncology (2012)

e14018 Background: Chemotherapy improves the survival rate of stage III colon cancer patients. The combination of oxaliplatin, 5-fluorouracil and leucovorin (the FOLFOX4 regimen) has emerged as the standard of care. Cognitive changes and disfunction after cancer chemotherapy are increasingly reported as a disturbing side-effect in cancer survivors. This prospective study evaluates potential alterations in cognitive function in Folfox4-treated patients. Methods: We evaluated 57 consecutive colorectal cancer patients who received adjuvant chemotherapy with FOLFOX4. Patients underwent a complete battery of neuropsychological tests at three different times: before (T0), at the end (T1) and six months after treatment (T2). Changes in neuropsychological test scores at T0, T1 and T2 were compared with a two tail t-test (T1-T0, T2-T1, T2-T0), using the repeated measure ANOVA model. Results: We have analyzed cognitive impairment (Mini Mental State Examination, MMSE), visuo-spatial memory, information processing speed (Trial Making Test-A and Trial Making Test-B), verbal memory (Rey Auditory Verbal Learning Test), emotional distress (Psychological Distress Inventory), anxiety (State and Trait Anxiety Inventory) and depression (Beck Depression Inventory). We found no cognitive impairment in time considered, as we found a median MMSE score of 27,51 ± 1,21 at T0, 27,63 ± 0,65 at T1 and 27,26 ± 1,17 at T2. We noticed some transient variations in tests evaluating verbal memory and in information processing speed performances. The only significative scores modifications were those related to anxiety and depression. Conclusions: We found no significant effect on cognitive function related to chemotherapy, the only little modification is about some emotional performance during chemotherapy. These findings may be explained by the central role of the psychological adaptation process, which occurs during the period from diagnosis to completion of treatment and is characterized by anxiety and adjustment depression. Our results seem to rule out any significant cognitive impairment due to adjuvant Folfox4 chemotherapy in colon cancer patients.
Linking Genotype to Clinical Phenotype in Multiple Sclerosis
Authors: Erin E. Longbrake, David A. Hafler
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Lack of association between HLA antigens and anorexia nervosa
Authors: A Kiss, A Hajek-Rosenmayr, A Haubenstock, S Wiesnagrotzki, G Moser
Journal: American Journal of Psychiatry (1988)

Studies of the human leukocyte antigen (HLA) system were performed in 37 patients with anorexia nervosa to confirm an alleged association with HLA-B16 and haplotype HLA-A26,B38. No correlation between anorexia nervosa and HLA, including HLA-DR, could be found.
AB0920 Metabolic Syndrome in Patients with Gout in Cameroon, Central Africa
Authors: F. Kemta Lekpa, M.S. Doualla, S. Choukem, H.N. Luma
Journal: Annals of the Rheumatic Diseases (2015)

Background Previous report has suggested that hyperuricemia and gout must be integrated into the metabolic syndrome items Objectives To evaluate the association between gout and metabolic syndrome in a sub-Saharan Cameroonian population Methods A cross-sectional study from January 2004 to December 2014 was conducted in the Rheumatology Unit of the General Hospital, Douala, Cameroon. We included patients with diagnosis of gout according to 1977 ACR criteria. Metabolic syndrome was defined according to the NCEP -ATP III criteria Results We included 511 patients (415 men and 96 women). The mean age was 55.9±10.8 years. The mean serum uric acid was 82.4 mg/L ±22.3, with hyperuricemia found in 401 patients (78.4%). The association between gout and items of metabolic syndrome were all significant (p<0.0001) ([Table 1][1]). This association was significant from the existence of at least two components of metabolic syndrome ([Table 2][2]). View this table: Table 1. Association between gout and items of metabolic syndrome View this table: Table 2. Association between gout and the number of items of metabolic syndrome Conclusions Gout is associated with metabolic syndrome in the Cameroonian population Disclosure of Interest None declared [1]: #T1 [2]: #T2
Chlamydia: a major challenge for public health
Authors: M JW Van de Laar, S A Morré
Journal: Eurosurveillance (2007)

Chlamydia trachomatis is the most commonly reported bacterial sexually transmitted infection (STI) in Europe. Genital chlamydial infection causes cervicitis and salpingitis in women and urethritis and conjunctivitis in both men and women.
PTU-241 Damage control with lavage and drainage in acute diverticulitis with peritonitis: texas endosurgery institute long-term follow-up
Authors: MA Hernandez, ME Franklin, JL Glass
Journal: Gut (2015)

<h3>Introduction</h3> The most common management for generalised purulent peritonitis due to perforated diverticulitis is emergency surgical intervention, because it has been associated to life threatening sepsis. For these cases Hartmann’s procedure is recommended as the standard treatment. Laparoscopic approach of peritoneal lavage and drainage (LLD) to treat severe acute diverticulitis has been criticised despite further studies including clinical trials. The aim of this presentation is to describe the experience with laparoscopic peritoneal lavage and drainage approach in patients with acute diverticulitis and generalised peritonitis. <h3>Method</h3> A consecutive serie database of patients with perforated diverticulitis who underwent emergent LLD was identified. All procedure-related information was collected and analysed. <h3>Results</h3> A total of 538 patients with acute diverticular disease were analysed [Female: 290 (54%), Male: 248 (46%), 140 patients underwent emergent laparoscopic procedure and 97 were managed by LLD between May 1995 and July 2014 for acute perforated diverticulitis. Demographic characteristics were analysed (female: 34; Male: 63), mean age 62.8 +/- 15.8, operative time was 99.7+/- 39.8 min, the estimated blood loss 34.4 +/- 21.2 ml. Three patients were reoperated, two of them to an open Hartmann’s procedure for worsening of septic symptoms during the immediate postoperative period, the other one to repeat the LLD (all of them with faecal peritonitis), hospital length stay (6.6 +/- 2.4 days); 57 of 97 LLD patients underwent an elective surgery for the source control, we had no mortality. <h3>Conclusion</h3> The LLD can be performed safely and effectively for patients with severe acute diverticulitis with generalised peritonitis. The clinical application of this approach shows acceptable long-term outcomes. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Vermeulen J, Gosselink MP, Hop WCJ, Lange JF, Coene PPLO, Van de Harst E, Weidema WF, Mannaerts GHH. Hospital mortality after emergency surgery for perforated diverticulitis. Ned Tijdschr Geneesk 2009;153:1209–1214 Parks TG. Natural history of diverticular disease of colon. Clin Gastroenterol 1975;4:53–69 Hart A, Kennedy J, Stebbings W. How frequently do large bowel diverticular perforate? An incidence and cross-sectional study. Eur J Gastroenterol Hepatol 2000;12:661–881
FRI0235 Comparison on Radiographic Progression for 5 Years Between Juvenile Onset Ankylosing Spondylitis and Adult Onset Ankylosing Spondylitis: Observation Study of Korean Spondyloarthropathy Registry (OSKAR) Data
Authors: T.-J. Kim, J.-H. Shin, I.-H. Sung, K.B. Joo, S. Lee, T.-H. Kim
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The most unique feature in ankylosing spondylitis (AS) is subchondral eburnation and syndesmophytes, possibly leading to ankylosis and spinal fusion. So far a few comparisons of spinal bone formation between adult onset AS (AoAS) and Juvenile onset AS (JoAS) have been done. However, prospective studies of this comparison have not been accomplished. <h3>Objectives</h3> The aim of this study was to evaluate difference of radiographic progression over 5 years between JoAS and AoAS. <h3>Methods</h3> A total of 533 patients (115 patients with JoAS, 418 patients with AoAS) from the Observation Study of Korean spondyloArthropathy Registry (OSKAR) cohort were enrolled. We used a two-step approach to compare the radiographic progression between the JoAS and the AoAS. First, all OSKAR data were analyzed in relation to the onset of disease on cross-sectional survey. Second, we analyzed the radiographic spinal progression between groups over 5 years. The modified Stoke AS Spinal Score (mSASSS) were examined by two experienced radiologists to validate the results. The collection of the clinical parameters was conducted to investigate the associations between clinical factors and the radiographic progression. Univariable and multivariable regression analyses were done after adjusting for potential confounding factors, such as age, gender, disease duration, history of peripheral arthritis, baseline CRP level, baseline mSASSS, and NSAID intakes). <h3>Results</h3> The agreement between the two readers regarding mSASSS was very good: ICC coefficient 0.75 (95% CI 0.61-0.82) and 0.71 (95% CI 0.58-0.82) at each time. On cross-sectional survey, in spite of adjusting for multiple comparisons by Bonferroni correction, the patients with JoAS had fewer mSASSS unit than those with AoAS (14.12±1.30 vs 18.58±0.85, p=0.005). In analysis over 5 years, the mean progression of mSASSS in patients with JoAS was 0.21±1.29 units, while that of mSASSS in patients with AoAS was 4.00±0.59 units (p=0.012). <h3>Conclusions</h3> The patients with JoAS had slower radiographic spinal damage progression over 5 years than those with AoAS. <h3>Disclosure of Interest</h3> None declared
Genetics and Personality
Authors: H J Eysenck
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A look at psychiatric decision making
Authors: B Roberts
Journal: American Journal of Psychiatry (1978)

The author reviews the efforts of medicine and psychiatry to understand their decision-making processes and notes the lack of psychiatric literature in this area. The decision table, a sophisticated form of algorithm, is introduced as a structure to help explain the decision-making process. This tool is applied to the evaluation and biological treatment of depression. Decision tables can be used as an educational tool, a method to facilitate the delivery of mental health care, a method to monitor the quality of treatment, and as a research tool.
The Growth Patterns of Some Transplantable Animal Tumors in Sponge Matrix Tissue Culture&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Joseph Leighton
Journal: JNCI Journal of the National Cancer Institute (1954)

The Growth Patterns of Some Transplantable Animal Tumors in Sponge Matrix Tissue Culture2 Joseph Leighton Joseph Leighton Laboratory of Pathology, National Cancer Institute,4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar 3The author is pleased to thank the following persons for kindly providing the tumors used in this study: Dr. E. Fekete of the Jackson Memorial Laboratory at Bar Harbor, Maine; Dr. Ivor Cornman of the Warwick Memorial Clinic of The George Washington University School of Medicine, Washington, D. C.; and Dr. Thelma B. Dunn, Dr. G. H. Algire, Dr. R. Greenfield, Dr. L. W. Law, and Dr. A. Symeonidis, all of the National Cancer Institute, Bethesda, Maryland. 4National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare. Author Notes JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 275–293, https://doi.org/10.1093/jnci/15.2.275 Published: 01 October 1954 Article history Received: 14 May 1954 Published: 01 October 1954
Do Human Tumors Show a Chromosome Pattern Specific for Each Etiologic Agent?3
Authors: Janet D. Rowley
Journal: JNCI Journal of the National Cancer Institute (1974)

A hypothesis is presented proposing a specific relationship between chromosomes and etiologic agents of various tumors. The postulates are based largely on data obtained from animal experiments. However, human data now available suggest that chromosome abnormalities in many diseases of man are not random. (PCS)
EU agrees tighter standards for medical devices
Authors: Rory Watson
Journal: BMJ (2016)

The European Union has agreed major changes to its 20 year old regulatory framework for medical devices. These will introduce stricter rules and higher standards on the manufacture, authorisation, and sale of medical devices, ranging from sticking plasters and pacemakers to artificial hips and breast implants.

The European Commission tabled the draft legislation in 2012 after the discovery the previous year of defective silicone gel breast implants manufactured by the French company Poly Implant Prothese (PIP). Political agreement on the amended legislation, along with new rules on in vitro diagnostic products, was finally reached late on 24 May after lengthy negotiations …
Replacement of the same lumen-apposing metallic stent for multiple necrosectomy sessions
Authors: Carlos Guarner-Argente, Juan Colán-Hernández, Mar Concepción-Martín, Miguel Martínez-Guillén, German Soriano, Sergio Sainz, Carlos Guarner
Journal: Endoscopy (2015)

Necrosectomy through a metal stent is feasible [1] but can be hindered by the limited mobility of the scope tip, and accidental removal of the stent during the extraction or fragmentation of necrotic material is not uncommon [2] [3] [4]. We describe a technique for removing and replacing the same lumen-apposing stent before and after each session of necrosectomy.
Life events, depressive symptoms, and immune function
Authors: M Irwin, M Daniels, E T Bloom, T L Smith, H Weiner
Journal: American Journal of Psychiatry (1987)

Because both bereavement and depression have been associated with impaired immune responses, the authors studied two indicators of immune function, natural killer (NK) cell activity and measures of T cell subpopulations, in 37 women who differed in the magnitude of recent life events. Women who had experienced major life changes had lower NK cell activity than women who had few changes. Severity of depressive symptoms in these women was associated with an impairment of NK cell activity, an absolute loss of suppressor/cytotoxic cells, and an increase in the ratio of T helper to T suppressor/cytotoxic cells.
Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer
Authors: Mingzhen Zhang, Emilie Viennois, Meena Prasad, Yunchen Zhang, Lixin Wang, Zhan Zhang, Moon Kwon Han, Bo Xiao, Changlong Xu, Shanthi Srinivasan, Didier Merlin
Journal: Biomaterials (2016)
&lt;TITLE&gt;Screening for Breast Cancer&lt;/TITLE&gt;
Journal: JAMA (2001)

On the why, whom and how of breast screening for carcinoma, the following answers can be provided: Why? As there is no primary prevention, secondary prevention by early diagnosis is the only way to reduce breast cancer mortality. On the other hand, breast cancers discovered by screening can be conservatively treated more often than when they become symptomatic; this is especially important in young patients. For whom? Every woman over the age of 35-40 should be accepted for breast cancer screening. In countries such as Switzerland it is unthinkable to impose screening or even to send personal invitations for screening to the population. Only repeated information through newspapers, TV and conferences will induce women to come for screening. The costs would be paid for by the patient, as medical insurances do not cover this type of preventive medicine. How? Only screening through mammography with or without breast palpation, performed by paramedical personnel, can be considered, because of the cost. It should be done outside the senologic consultation setup for symptomatic patients where a doctor is in charge of the clinical consultation. As Doctor Van der Linde said at the end of his talk at the last Convention of the Swiss Senology Society in Lausanne, pilot projects for breast screening in Switzerland should be started. The Swiss Cancer Society has lately created a commission for early detection of breast cancer to study ways of launching a project.
SP0245 The European Status Quo and the Educational Needs of Young Rheumatologists
Authors: F. Sivera
Journal: Annals of the Rheumatic Diseases (2015)

Most European countries offer post-graduate training programs in rheumatology. These programs are designed by national authorities. European recommendations on the structure and content of specialty training programs have been developed, however, it is unclear how far implementation has been undertaken. There is an increasing awareness of the heterogeneity of rheumatology post-graduate training across European countries. Educational activities outside the training programs should adapt to the unmet educational needs of young rheumatologists. <h3>Disclosure of Interest</h3> None declared
A Comparative Study of the Morphology and Glucuronidase Activity in 44 Gastrointestinal Neoplasms
Authors: W H FISHMAN, R BIGELOW
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article A Comparative Study of the Morphology and Glucuronidase Activity in 44 Gastrointestinal Neoplasms Get access William H. Fishman, Ph.D., William H. Fishman, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Bigelow, M. D. Robert Bigelow, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 5, April 1950, Pages 1115–1122, https://doi.org/10.1093/jnci/10.5.1115 Published: 01 April 1950 Article history Received: 10 December 1949 Published: 01 April 1950
Response to: ‘Issues with anti-Gr1 antibody-mediated myeloid-derived suppressor cell depletion’ by Xing<i>et al</i>
Authors: Xiang-Yang Wang, Huanfa Yi, Juan Li
Journal: Annals of the Rheumatic Diseases (2016)

Myeloid-derived suppressor cell (MDSC) is a heterogeneous myeloid cell population that can broadly be characterised as CD11b+Gr-1+ cells in mice. MDSC can be further classified into two main cell subsets, granulocytic MDSC (G-MDSC, CD11b+Ly6ClowLy6G+) and monocytic MDSC (M-MDSC, CD11b+Ly6ChighLy6G−).1 To address the role of MDSC in disease settings (eg, cancer and autoimmune disorders) and to evaluate the potential therapeutic benefits of targeting MDSC in preclinical models, different strategies, including anti-Gr-1 antibodies2–5 and pharmacological inhibitors (eg, gemcitabine and 5-fluorouracil),6 ,7 have been widely used to selectively remove mouse MDSC. The use of these reagents in combination with appropriate experimental systems has advanced significantly our current understanding of these myeloid cells in multiple physiological and pathological processes. Xing et al 8 raised an issue with the use of anti-Gr-1 (RB6-8C5) for depletion of MDSC, which indeed has long been recognised by the research community. Anti-Gr-1 antibodies can bind to two Ly6 superfamily molecules, Ly6G and Ly6C, which are preferentially expressed on the granulocytes and monocytes, respectively. The differential expression levels of Gr-1 on G-MDSC and M-MDSC may result in different sensitivities to cross-linking of or depletion …
An outbreak of Salmonella enteritidis food poisoning in a psychiatric hospital in Dublin, Ireland
Authors: T Grein, D O’Flanagan, T McCarthy, T Prendergast
Journal: Eurosurveillance (1997)

On 29 August 1996 Ireland&#39;s Eastern Health Board (EHB) was informed of an outbreak of gastrointestinal illness in a psychiatric hospital in Dublin. Fifty people among 240 members of staff and 183 patients had reportedly fallen ill since 27 August and new
SP0056 Functional Genomics in SPA
Authors: G. Chiocchia
Journal: Annals of the Rheumatic Diseases (2015)

Spondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder, with few effective treatments such as TNF blockers which can temporarily suppress inflammation, but none has yet proven to affect long-term disease outcome. There is a deep need to better understand pathological mechanisms controlling both initiation and progression of SpA. During the last 10 years multiple large scale studies including genome-wide genetic and gene expression analysis. These approaches are highly powerful to identify new genetic determinants and molecular mechanisms potentially involved in the disease but they also demonstrated some limits showing that there is a need to rethink these approaches in a more integrated view. In this presentation we will discuss the potential utility of such approach, and present data illustrating the comparison between molecular signatures obtained in human cells as well as in animal model of SpA and how to link genetic studies to gene expression studies. <h3>Disclosure of Interest</h3> None declared