tbuckley/cabot-search huggingface dataset:
PWE-256 Enhanced radiosensitivity of colorectal cancer cells by targeting BCL-3
Authors: AC Chambers, K Gash, T Collard, C Paraskeva, A Williams, M Thomas
Journal: Gut (2015)

<h3>Introduction</h3> Colorectal cancer remains the second most common cause of cancer related death in the UK. The successful management of rectal cancer has improved significantly with changes to surgical technique and the addition of pre-operative chemo-radiotherapy. A significant proportion of patients fail to respond to neo-adjuvant therapy. BCL-3 expression (an NF-KB homodimeric binding protein) is associated with poor prognosis in colorectal cancer patients,<sup>1</sup>and has been shown to drive expression of Cancer Stem Cell (CSC) markers in colorectal cancer.<sup>2,3,4</sup>Importantly evidence shows that CSCs contribute to tumour development and therapeutic resistance.<sup>5</sup>It was hypothesised that expression of BCL-3 could be driving cell survival after radiation, and therefore represent a novel biomarker for therapeutic response. <h3>Method</h3> Established colorectal cells lines LS174T and HCA7 were cultured in flasks/plates. Suppression of BCL-3 expression was achieved by transfection with short interfering RNA (siRNA), cells were irradiated with 1–2.5Gy γ-radiation (Cs-137 source). Cell yield and apoptosis were determined. Cell viability was assessed using a crystal violet assay, protein analysis by Western Blotting. <h3>Results</h3> BCL-3 suppression results in reduced cell yield and increased apoptosis in LS174T and HCA7 cells. Suppression of BCL-3 expression combined with γ-irradiation results in a significant decrease in cell viability of both LS174T (40% reduction in cell viability at 1Gy, p = 0.028; 54% reduction in cell viability at 2.5Gy, p = 0.005) and HCA7 cells (33% reduction in cell viability at 1Gy, p = 0.017; 50% reduction in cell viability at 2.5Gy, p = 0.031). <h3>Conclusion</h3> We have shown for the first time that suppressing BCL-3 expression results in radio-sensitisation in an in-vitro colorectal cancer model, the mechanisms of which are currently under investigation. Work is underway to validate this research with in-vivo tissue samples; the aim is to determine whether BCL-3 expression levels correlate with therapeutic response to radiotherapy in rectal cancer patients and whether BCL-3 levels could be used to stratify patient treatment. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Puvvada SD <i>et al</i>. Oncology. 2010;78:181–188 Al-Kharusi, MR <i>et al</i>. Carcinogenesis. 2013;34:1150–1157 Smartt, HJ <i>et al</i>. Gut. 2012;61:1306–1314 Urban BC <i>et al</i>. BCL-3 promotes colorectal tumour cell survival through activation of the AKT signalling pathway. <i>In revision. </i>2015 Pattabiraman, DR <i>et al</i>. Nature reviews. Drug discovery. 2014;13:497–512
Neurofibromatosis 2
Authors: R L Martuza, R Eldridge
Journal: New England Journal of Medicine (1988)

THE neurofibromatoses consist of two distinct disorders,1 , 2 the genes for which have recently been located on separate chromosomes.3 4 5 6 Neurofibromatosis 1, also called von Recklinghausen's neurofibromatosis, affects approximately 100,000 people in the United States. It is a common and potentially serious inherited disorder of the human nervous system.1 Neurofibromatosis 2, also known as bilateral acoustic neurofibromatosis, affects several thousand Americans and has a molecular origin similar to that of some of the common sporadically occurring tumors of the nervous system — meningiomas, schwannomas, neurofibromas, and possibly gliomas.3 This review discusses the clinical features, diagnostic advances, treatment dilemmas, and basic research findings . . .
Patients are being let down by lack of electronic health records, finds review
Authors: Helen Mooney
Journal: BMJ (2016)

Patients have only limited access to electronic health records and their expectations are not being met by the NHS, according to the findings of a review into the roll-out of patient records across the United Kingdom.1

NHS organisations are also missing out on ways to save money and improve patient care because of the lack of large scale implementation and access to personal health records.

The review of current UK activity in personal electronic health and care records (PHRs) was carried out by the Royal College of Physicians (RCP) Health Informatics Unit for NHS England. It found a lack of available information on the use of …
AB0620 Long-Term Outcome of SLE Patients with Joint Ultrasound Abnormalities Associated to Hand Inflammatory Arthralgia:
Authors: T.C. Salman Monte, P. Corzo, V. Torrente-Segarra, L. Polino, M. Lisbona, L. Orpinell, D. Marqués, J. Carbonell Abellό
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> In the past years, the information about the utility of joint ultrasound (US) in SLE is raising. We know SLE patients with hand and wrist arthralgia might show joint US abnormalities (1). It is yet to be demonstrated the utility of joint US in the prediction of worse clinical outcome in SLE patients. <h3>Objectives</h3> To describe and to compare long-term clinical outcome in SLE patients who showed inflammatory joint US abnormalities associated to the presence of hand and wrist arthralgia. <h3>Methods</h3> A prospective longitudinal study of patients with SLE (fullfilling ACR 1982 criteria) who showed baseline hand and wrist arthralgia and inflammatory joint US abnormalities that were compared to healthy SLE patients were assessed. These patients were regularly attended at the Rheumatology department at Hospital del Mar. Two study groups were defined: “cases,” patients with hand and wrist arthralgia and morning stiffness&gt;1h and abnormal joint US at baseline; and “controls” patients without arthralgia or morning stiffness and normal US at baseline. An abnormal joint US was defined by the presence of joint effusion and/or synovial hypertrophy and/or tenosynovitis with or without Power Doppler signal in wrist and/or 2nd-5th MCP joints and/or 2nd-5th PIP joint as defined OMERACT-7 (2). Clinical, serological and treatmets parameters were registered at baseline, during the follow up time and in the last assessment. <h3>Results</h3> <h3>Conclusions</h3> Patients with hand and wrist arthralgia and abnormal joint US showed a higher prevalence of joint involvement during follow-up, as well as a greater need for treatment with synthetic DMARDs such as hydroxychloroquine and methotrexate, compared with those without such symptoms who also had normal joint US. The joint US might help us on the study ofSLE patients with hand and wrist arthralgia who also show inflammatory abnormalities by joint US. Patients with abnormal joint US at baseline seems to suffer a worse joint involvement outcome. <h3>References</h3> Torrente-Segarra V et al. Joint Bone Spine. 2013;80:402-6. Cheung PP et al. Int J Rheum Dis.2014;17:776-81. <h3>Acknowledgements</h3> Sergi Mojal. AMIB. <h3>Disclosure of Interest</h3> None declared
PWE-243 Narcotic bowel syndrome: a local experience of the hidden burden
Authors: MW Johnson, T Prouse
Journal: Gut (2015)

<h3>Introduction</h3> The use of prescribed narcotic drugs has escalated throughout UK. There are 220,000 people within the Luton CCG catchment area and between June–November 2014, 32,956 prescriptions had been provided for strong opioid therapy. Not only is this a costly unchecked market, but much of this is taken for abdominal pain. Narcotic Bowel Syndrome (NBS) is under recognised and believed to be increasing in prevalence worldwide. NBS is a subset of opioid bowel dysfunction that is characterised by chronic or frequently recurring abdominal pain that worsens with continued or escalating dosages of narcotics. We attempted to assess the demand placed on the NHS system by NBS patients. <h3>Method</h3> In 2014 we started to collect the names of patients seen in gastroenterology clinics or during hospital admission where the clinician felt the patient was suffering from NBS. This was either thought to be the main cause or contributing factor to their symptomatology. A 12 year retrospective review was then made using the hospital coding system to assess the demand made by these patients on the Luton and Dunstable University Hospital through either outpatient clinic visits and/or hospital admissions. <h3>Results</h3> A database collated the names of 41 patients with NBS. Between January 2000 and December 2014 this cohort of patients have had a total of 660 hospital admissions and 1407 outpatient appointments. In that 15 year time period, the patients had an average of 16 hospital admissions (1.1 per year) each, and 34.3 outpatient clinic appointments each (2.3 per year). During this review period 2 patients died; one 46y old male died from a definite overdose, and one 33y old died from a probable overdose. <h3>Conclusion</h3> NBS is a poorly recognised condition that places a huge demand on the NHS system with regards to time, resources and finances. Early recognition could prevent a costly and potentially fatal pathway of deterioration. <h3>Disclosure of interest</h3> None Declared.
The Hike
Authors: Elizabeth Ann Sastre
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effectivity Of Complement-Dependent Cytotoxicity Induced By Therapeutic Antibodies In Acute Lymphoblastic Leukemia Is Dictated By Antigen Expression Levels and Curtailed By Membrane-Bound Complement Regulatory Proteins
Authors: Floris C Loeff, Esther H.M. van Egmond, Judith Olde Wolbers, J.H. Frederik Falkenburg, Constantijn J.M. Halkes, Inge Jedema
Journal: Blood (2013)
Recurrent Alveolar Soft Part Sarcoma on Bone Scintigraphy
Authors: He Huang, Yue Chen
Journal: Clinical Nuclear Medicine (2015)

A 15-year-old girl experienced an alveolar soft part sarcoma in the right thigh 3 years ago, which was resected. Postsurgical recovery was uneventful until approximately 1 year ago when she began to feel mild local tenderness and gradual swelling around the surgical scars. The patient underwent Tc-MDP bone scintigraphy to evaluate osseous metastases. Although no lesion in the bone was identified, the images showed abnormally increased activity in the region of known focal lesion.
P2-148: Synchrotron based FTIR spectroscopy of single cells. Applications in lung cancer diagnosis and management
Authors: Josep Sulé-Suso, Ganesh D. Sockalingum, Achim Kohler, Fariba Bahrami, Marine Cotte, Jacek K. Pijanka, Ying Yang, Michel Manfait, Paul Dumas
Journal: Journal of Thoracic Oncology (2007)
THU0358 The Ability of the Health System to Identify the Burden of Spondyloarthritis in Two Regions of Serbia: A Eular Survey
Authors: M.I. Zlatkovic-Svenda, R.M. Stojanovic, S.B. Sipetic-Grujicic, M.M. Radak-Perovic, N.S. Damjanov, F. Guillemin
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To determine spondyloarthritis (SpA) prevalence in two different regions of Serbia, as part of the European League Against Rheumatism (EULAR) prevalence survey; to assess the ability of the health system to identify and treat patients with SpA. <h3>Methods</h3> Survey comprised a two-stage approach with a sample of urban population in 2 areas: Belgrade, located in the north and Cacak, Uzice and Krusevac in the south, covering 36.5% of the total Serbian population. In a detection phase, every 100-th telephone number was contacted to answer a previously validated screening telephone questionnaire. Confirmation of cases was by contact with the patient9s rheumatologist or rheumatological examination. Prevalence results were standardized for age and sex according to Serbian population (national census 2002). Confirmed SpA cases were asked two more questions: “How long had you had symptoms before you were given the diagnosis of SpA” and “How had you been treated for that period of time”. <h3>Results</h3> 6213 people were contacted; 63.6% answered the survey; 66 were examined. A total of 16 SpA cases were identified (5 newly diagnosed). The standardized SpA prevalence for the north was 0.28% (95% confidence interval [95% CI] 0.08;0.48); 0.31 (95% CI 0.00;0.65) for men and 0.25% (95% CI 0.01;0.49) for women; for the south 0.42% (0.02;0.82); 0.41 (0.02;0.81) for men and 0.43% (0.04;0.82) for women. Mean (SD) time (months) to SpA diagnosis was 23.6 (24.9) for the north and 13.6 (11.3) for the south; 19.2 (20.2) for Serbia. Before they were given the SpA diagnosis, all patients were treated with NSAIDS, but mostly “on demand” (56.2%), some of them with physical therapy (43.7%) and benzodiazepins (18.7%). <h3>Conclusions</h3> SpA prevalence in Serbia does not differ much between southern and northern part of the country as well as between women and men. Diagnostic delay for SpA is 19 months and most of the patients were inadequately treated for that period of time. One third of the revealed SpA cases were not diagnosed previously. <h3>Disclosure of Interest</h3> None declared
Scaled ratings of DSM-III personality disorders
Authors: F Kass, A E Skodol, E Charles, R L Spitzer, J B Williams
Journal: American Journal of Psychiatry (1985)

The authors describe the use of a 4-point rating scale for DSM-III axis II categories in a hospital-based outpatient clinic. Fifty-one percent of the sample met the criteria for one or more DSM-III personality disorders. This increased to 88% when the sample also included patients rated as having "some traits" or "almost meets DSM-III criteria." Frequency distributions were obtained for each of the 11 personality disorders, and a factor analysis was derived that was similar to the groupings described in DSM-III.
Molecular-based surveillance of campylobacteriosis in New Zealand – from source attribution to genomic epidemiology
Authors: P Muellner, E Pleydell, R Pirie, M G Baker, D Campbell, P E Carter, N P French
Journal: Eurosurveillance (2013)

Molecular-based surveillance of campylobacteriosis in New Zealand contributed to the implementation of interventions that led to a 50% reduction in notified and hospitalised cases of the country's most important zoonosis. From a pre-intervention high of 384 per 100,000 population in 2006, incidence dropped by 50% in 2008; a reduction that has been sustained since. This article illustrates many aspects of the successful use of molecular-based surveillance, including the distinction between control-focused and strategy-focused surveillance and advances in source attribution. We discuss how microbial genetic data can enhance the understanding of epidemiological explanatory and response variables and thereby enrich the epidemiological analysis. Sequence data can be fitted to evolutionary and epidemiological models to gain new insights into pathogen evolution, the nature of associations between strains of pathogens and host species, and aspects of between-host transmission. With the advent of newer sequencing technologies and the availability of rapid, high-coverage genome sequence data, such techniques may be extended and refined within the emerging discipline of genomic epidemiology. The aim of this article is to summarise the experience gained in New Zealand with molecular-based surveillance of campylobacteriosis and to discuss how this experience could be used to further advance the use of molecular tools in surveillance.
Serologic Evidence of Viral Infection in South American Monkeys&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: S. S. Kalter, R. L. Heberling
Journal: JNCI Journal of the National Cancer Institute (1972)

Journal Article Serologic Evidence of Viral Infection in South American Monkeys Get access S. S. Kalter, S. S. Kalter Division of Microbiology and Infectious Diseases, Southwest foundation for Research and Education, San Antonio, Texas 78228 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. L. Heberling R. L. Heberling Division of Microbiology and Infectious Diseases, Southwest foundation for Research and Education, San Antonio, Texas 78228 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 251–260, https://doi.org/10.1093/jnci/49.1.251 Published: 01 July 1972
Steap3 Is a Novel Candidate Gene for Regulating the RBC Blood Storage Lesion By Mitigating Peroxidation of Membrane Lipids in a Mouse Model
Authors: Karen S deWolski, Hayley R Waterman, Peter C Thomson, James D Gorham, Matthew S Ranson, Heather L Howie, Adam Munday, Jill M Johnsen, James C. Zimring
Journal: Blood (2014)
MRSA in nursing homes in the Netherlands 1989 to 1998: a developing reservoir?
Authors: W Goettsch, E Geubbels, W Wannet, M G R Hendrix, J H T Wagenvoort, A J de Neeling
Journal: Eurosurveillance (2000)

The prevalence of methicillin resistant Staphylococcus aureus (MRSA) in Dutch nursing homes in 1998 was higher than that found in 1989 to 1997. The increased prevalence of MRSA could lead to colonisation outside these nursing homes. A study of the prevale
Mechanism of Autocatalytic Oxidation of Oxyhemoglobin by Nitrite
Authors: Hiroaki Kosaka, Itiro Tyuma
Journal: Environmental Health Perspectives (1987)

Oxidation of oxyhemoglobin by nitrite is characterized by the presence of a lag phase followed by the autocatalysis. In phosphate buffer, an asymmetric ESR signal is detected at g = 2.005 (hereafter referred to as the g = 2 radical) during the oxidation which is similar to that of the methemoglobin free radical generated from methemoglobin and H2O2. Catalase and KCN prolong the oxidation, indicating the involvement of H2O2 and methemoglobin in the reaction. Superoxide dismutase, on the other hand, does not modify the oxidation. The present results suggest a chain reaction mechanism for the oxidation in which the g = 2 radical catalyzes the formation of NO.2 from NO-2 by a peroxidase action and NO.2 oxidizes oxyhemoglobin. However, in N,M-bis(2-hydroxyethyl)iminotris(hydroxymethyl)methane (bistris) buffer, superoxide dismutase markedly elongates the lag phase and accelerates the autocatalysis: bistris scavenges the g = 2 radical and a radical derived from bistris reduces O2 to O-2.
L-dopa challenge and relapse in schizophrenia
Authors: M Davidson, R S Keefe, R C Mohs, L J Siever, M F Losonczy, T B Horvath, K L Davis
Journal: American Journal of Psychiatry (1987)

Neuroleptic administration has been shown to be superior to placebo in prolonging schizophrenic remission. However, individual patients are able to maintain long periods of remission in the absence of neuroleptic treatment, while others relapse soon after neuroleptic withdrawal. This study attempted to predict time to relapse in 28 schizophrenic patients withdrawn from neuroleptics and challenged with L-dopa for 7 days, then followed until relapse. Time to relapse correlated significantly with L-dopa-induced increase in BPRS score (p = .006). Five of six patients who responded to L-dopa relapsed within 4 weeks after L-dopa administration, while only four of 22 who did not respond relapsed in a comparable period.
SP0131 Fibromyalgia: What is New
Authors: L.J. Crofford
Journal: Annals of the Rheumatic Diseases (2015)

Further clarification of the impact of FM classification criteria has emerged with a higher prevalence and greater proportion of men identified with the modified 2010 criteria. This together with ongoing epidemiologic studies has confirmed the relationships between FM, other pain conditions, and mood disorders. Advances in the understanding of FM physiology have continued to evolve with advanced neuroimaging studies confirming altered central representation of pain as well as more static changes in brain volumes and brain region connectivity. Additional studies reveal alterations in brain function during cognitive processing. In addition to these advances, there has been re-focused attention on peripheral mechanisms that may initiate or maintain centrally amplified pain, specifically focusing on evidence for involvement of cytokines, oxidative stress and mitochondrial dysfunction, and small fiber neuropathy. The potential role of autonomic dysfunction as a unifying factor in these peripheral changes continues to be investigated. Few advances were made in treatments for FM with most studies re-confirming the limited effectiveness of available pharmacologic treatments and re-affirming the utility of non-pharmacologic treatment modalities. The search for novel approaches to treatment may be informed by studies of the physiology of FM. <h3>Disclosure of Interest</h3> None declared
Trends in hospital versus community treatment of mental illness: a Texas example
Authors: J L Claghorn, G W Mcbee, L Roberts
Journal: American Journal of Psychiatry (1976)

The authors present statistics from Harris County, Tex., that indicate community psychiatry is making progress toward its goals of decreasing inpatient hospitalization and increasing services to the community. At the present ratio of services, a 30%-40% increase in outpatient services could theoretically eliminate the inpatient system. The authors stress the fact that inpatient facilities are still vital and offer directives for the future roles of the hospital and of community psychiatry.
SP0217 From Theory to Practice: Case Study from the Sarah Trial
Authors: M. Dritsaki
Journal: Annals of the Rheumatic Diseases (2015)

The Strengthening And stretching for Rheumatoid Arthritis of the Hand (SARAH) trial was a pragmatic, multi-centre, randomised controlled trial conducted with one year follow-up across 17 National Health Service hospital trusts in England between 2009 and 2011. 490 participants with rheumatoid hand arthritis were randomised to either an exercise programme (n=246) or to usual care (n=244). The aim of the lecture is to provide an understanding of the basic language and concepts and usefulness of economic evaluation within the clinical trials framework using the SARAH trial as a case study. More specifically the lecture will present –the design of trial based economic evaluation –Analysis of cost (and effectiveness) data –Advantages and challenges of trial based economic evaluation –Randomised Controlled Trial (RCT)-based evidence and decision making <h3>References</h3> Williams MA, Williamson EM, Heine PJ, Nichols V, Glover MJ, Dritsaki M, et al. Strengthening And stretching for Rheumatoid Arthritis of the Hand (SARAH). A randomised controlled trial and economic evaluation. Health Technol Assess 2015;19(19). Lamb SE, Williamson EM, Heine PJ, Adams J, Dosanjh S, Dritsaki M, Glover MJ, Lord J, McConkey C, Vnichols, Rahman A, Underwood M, Williams MA, on behalf of the SARAH Trial group (2014). Exercises to improve function of the rheumatoid hand: a randomised controlled trial The Lancet 2015;385:421-429. <h3>Disclosure of Interest</h3> None declared