tbuckley/cabot-search huggingface dataset:
Endoscopic sclerotherapy with a high concentration of n-butyl-2-cyanoacrylate for anastomotic varices after choledochojejunostomy
Authors: Sho Kitagawa, Takahiro Sato, Mutsuumi Kimura
Journal: Endoscopy (2015)

Anastomotic varices are an uncommon cause of variceal bleeding. After choledochojejunostomy, the anastomosed afferent jejunal loop may have a propensity to form varices, with hepatopetal flow [1] [2]. Endoscopic sclerotherapy has the potential to cause intrahepatic obstruction of the portal vein [3] [4] [5]. This report describes endoscopic sclerotherapy with a high concentration of n-butyl-2-cyanoacrylate for anastomotic varices after choledochojejunostomy.
Re: Pasquale Rescigno, David Lorente, Diletta Bianchini, et al. Prostate-specific Antigen Decline After 4 Weeks of Treatment with Abiraterone Acetate and Overall Survival in Patients with Metastatic Castration-resistant Prostate Cancer. Eur Urol 2016;70:724–31
Authors: Vincenza Conteduca, Cristian Lolli, Ugo De Giorgi
Journal: European Urology (2016)
Borderline syndromes in childhood: criteria for diagnosis
Authors: J R Bemporad, H F Smith, G Hanson, D Cicchetti
Journal: American Journal of Psychiatry (1982)

There is currently a great deal of confusion regarding the diagnostic status of children with borderline disorders and a tendency to apply criteria for borderline adults to the diagnosis of these children without allowing for developmental differences. On the basis of their experience with 24 latency-age children, the authors propose diagnostic criteria in an effort to establish a uniformity in the diagnosis of these children. Major areas of psychopathology include fluctuation of functioning, nature and extent of anxiety, thought content and processes, relationships to others, and lack of control. The authors also found a high frequency of organic impairment, physical abuse, and familial disturbance.
A Solitary Metastasis for a Malignant Schwannoma in the Gallbladder Detected by 18F-FDG PET/CT
Authors: Laura Evangelista, Marta Burei, Umberto Basso
Journal: Clinical Nuclear Medicine (2016)

A 63-year-old woman with a history of malignant schwannoma in the left shoulder (pT1aNxMx) was treated with surgical resection in 2012. During follow-up, patient developed a metastasis in the right lung treated by further surgical intervention. For a suspicion on persistent disease in the lung, patient was sent to FDG PET/CT examination, which showed a focal uptake in the gallbladder. The patient underwent cholecystectomy, and a solitary metastasis from schwannoma was diagnosed by pathology. This case highlights that, in patients with a malignant schwannoma, a careful differential diagnosis should be made in case of a significant FDG uptake in the gallbladder.
Hematopoietic growth factors and high-dose chemotherapy: will grams succeed where milligrams fail?
Authors: G D Demetri, J D Griffin
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.5.761 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 1692086 Hematopoietic growth factors and high-dose chemotherapy: will grams succeed where milligrams fail? G D DemetrixG D DemetriSearch for articles by this author , J D GriffinxJ D GriffinSearch for articles by this author Show More Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA. https://doi.org/10.1200/JCO.1990.8.5.761 First Page PDF © 1990 by American Society of Clinical Oncology
1994 Homer W. Smith Award. From flies to physiology--accidental findings along the trail of renal NaCl transport.
Authors: P S Aronson
Journal: Journal of the American Society of Nephrology (1995)

Journal of the American Society of Nephrology : JASN 5(12):p 2001-2013, June 1995. | DOI: 10.1681/ASN.V5122001
Resolution of Skin Fibrosis by Neutralization of the Antifibrinolytic Function of Plasminogen Activator Inhibitor 1
Authors: Raphaël Lemaire, Timothy Burwell, Hong Sun, Tracy Delaney, Julie Bakken, Lily Cheng, Marlon C. Rebelatto, Meggan Czapiga, Isabelle de‐Mendez, Anthony J. Coyle, Ronald Herbst, Robert Lafyatis, Jane Connor
Journal: Arthritis & Rheumatology (2015)

Systemic sclerosis (SSc) is a fibrotic disease characterized by an obliterative vasculopathy with thrombosis and impairment of the coagulation-fibrinolysis balance. Plasminogen activator inhibitor 1 (PAI-1) is the major inhibitor of profibrinolytic plasminogen activators (PAs). This study was undertaken to evaluate the contribution of PAI-1 to SSc pathology in the skin.PAI-1 was evaluated in skin from patients with diffuse SSc (dSSc) and those with limited SSc (lSSc) by immunohistochemistry. The contribution of PAI-1 to SSc pathology was tested in vivo in murine graft-versus-host disease (GVHD) and bleomycin models of progressive skin fibrosis and in vitro in dermal human microvascular endothelial cells (HMVECs) using a monoclonal antibody that selectively prevents the binding of PAI-1 to PA.Skin from patients with dSSc and those with lSSc showed increased PAI-1 levels in the epidermis and microvessel endothelium. PAI-1 neutralization in the GVHD model led to a dramatic, dose-dependent improvement in clinical skin score, concomitant with vasculopathy resolution, including a reduction in fibrinolysis regulators and vascular injury markers, as well as reduced inflammation. Resolution of vasculopathy and inflammation was associated with resolution of skin fibrosis, as assessed by reduction in collagen content and expression of key profibrotic mediators, including transforming growth factor β1 and tissue inhibitor of metalloproteinases 1. Similar to the GVHD model, PAI-1 neutralization reduced dermal inflammation and fibrosis in the bleomycin model. PAI-1 neutralization stimulated plasmin-mediated metalloproteinase 1 activation in dermal HMVECs.Our findings indicate that neutralization of the antifibrinolytic function of PAI-1 resolves skin fibrosis by limiting the extent of initial vascular injury and connective tissue inflammation. These data suggest that PAI-1 represents an important checkpoint in disease pathology in human SSc.
Vital Signs: Estimated Percentages and Numbers of Adults with Indications for Preexposure Prophylaxis to Prevent HIV Acquisition — United States, 2015
Authors: Dawn K. Smith, Michelle Van Handel, Richard J. Wolitski, Jo Ellen Stryker, H. Irene Hall, Joseph Prejean, Linda J. Koenig, Linda A. Valleroy
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

In 2014, approximately 40,000 persons in the United States received a diagnosis of human immunodeficiency virus (HIV) infection. Preexposure prophylaxis (PrEP) with daily oral antiretroviral medication is a new, highly effective intervention that could reduce the number of new HIV infections.CDC analyzed nationally representative data to estimate the percentages and numbers of persons in the United States, by transmission risk group, with indications for PrEP consistent with the 2014 U.S. Public Health Service's PrEP clinical practice guideline.Approximately 24.7% of sexually active adult men who have sex with men (MSM) (492,000 [95% confidence interval {CI} = 212,000-772,000]), 18.5% of persons who inject drugs (115,000 [CI = 45,000-185,000]), and 0.4% of heterosexually active adults (624,000 [CI = 404,000-846,000]), had substantial risks for acquiring HIV consistent with PrEP indications.Based on current guidelines, many MSM, persons who inject drugs, and heterosexually active adults have indications for PrEP. A higher percentage of MSM and persons who inject drugs have indications for PrEP than heterosexually active adults, consistent with distribution of new HIV diagnoses across these populations.Clinical organizations, health departments, and community-based organizations should raise awareness of PrEP among persons with substantial risk for acquiring HIV infection and their health care providers. These data can be used to inform scale-up and evaluation of PrEP coverage. Increasing delivery of PrEP and other highly effective HIV prevention services could lower the number of new HIV infections occurring in the United States each year.
SP0119 Bridging the Gap with Education: What Can Rheumatologists Learn from Primary Care?
Authors: Z. Paskins
Journal: Annals of the Rheumatic Diseases (2015)

Rheumatologists and clinicians in primary care communicate on a daily basis. Good communication and relations between primary and secondary care are essential for optimum patient care. When communication fails, patient care suffers: lack of clarity of roles leads to patients being lost in the middle with neither side taking responsibility for aspects of care. One difficulty in clarifying roles is the lack of clarity and agreement between what conditions and aspects of management constitute primary vs secondary care territory. When considering the gap between primary and secondary care, the most commonly touted solution is more musculoskeletal and rheumatological education for family medicine doctors (General Practitioners – GPs). This is undoubtedly an important area of need and I will describe some important innovations in GP musculoskeletal education from the UK. However, in this talk I will suggest that the rheumatology – primary care education paradigm needs to shift, with rheumatology considering what it can learn from primary care. Most rheumatologists progress through their training with little or no exposure to primary care. GPs are expert in managing uncertainty, weeding out important symptoms in messy prodromes of disease, dealing with multi-morbidity and polypharmacy, and transferring evidence based population level medicine and making it relevant to the individual. All of these skills are important for rheumatologists. I9ll conclude with some possible implications for rheumatologists in training and examples of working in partnership that have facilitated shared learning for both parties. <h3>Disclosure of Interest</h3> None declared
PTH-032 D2 biopsies in weight loss referrals – is it necessary and cost effective?
Authors: S Kotha, C Holohan, A Gera, A Loganayagam
Journal: Gut (2015)

Introduction Biopsies from the second part of the duodenum (D2) are commonly taken in patients undergoing upper GI endoscopy for weight loss. This is done as weight loss can be an important presentation of coeliac disease. Both BSG (British Society of Gastroenterology) and NICE (National Institute for Health and Care Excellence) guidelines recommend that patients with suspected coeliac disease should be screened with serology initially. If coeliac serology is negative then small bowel biopsies are generally not necessary. Despite this D2 are routinely taken. Random duodenal biopsies result in increased workload and cost. The aim of this study was to determine if D2 were necessary and cost effective in every patient undergoing an oesophagogastroduodenoscopy (OGD) for weight loss. Method We analysed retrospective data collected from ADAM (endoscopy database) at Queen Elizabeth Hospital for a period of 1 year (2013) for all the OGDs and D2 undertaken with the referral indication of weight loss. Demographic data, endoscopic findings, histological findings and cost of analysing histology were evaluated. Results 236 patients underwent OGD during the study period under the referral indication of weight loss. All 236 patients had D2 taken. 4 patients were excluded (2 had a prior diagnosis of coeliac and 2 did not have histology results on our system).15 patients (6.5%) had positive histology. 2 patients (0.8%) had evidence of coeliac disease on histology, but both had evidence of iron deficiency anaemia in addition to weight loss. 2 patients had intraepithelial lymphocytes but normal villi and negative serology (not treated as coeliac disease as patients were asymptomatic and gaining weight). 1 patient has giardia on the biopsy. 1 patient had mild villous blunting, but had metastatic lung disease and was not followed up in our clinic. 9 patients (3.8%) had non-specific duodenitis on biopsy. The overall pick up rate for significant pathology on D2 was only 2.5%. Conclusion The pickup rate for significant pathology on D2 for weight loss was poor. The 2 patients with definitive diagnosis of coeliac also had evidence of iron deficiency anaemia. The cumulative cost of analysing these biopsies was £ 7775(£33.6/biopsy). Despite this patients with weight loss seem to have D2 rather than serological testing. This may be due to the fact that majority of these patients undergo an OGD and it was considered easier to perform D2 at the same time. However, this increases the burden of cost on the health care services. D2 should only be performed in patients undergoing an OGD for weight loss, if coeliac serology is positive or there is a high index of suspicion for coeliac disease. Disclosure of interest None Declared.
AB1260-HPR An Indian (Asian) Version of Rheumatoid Arthritis Pain Scale (RAPS)- Validation &amp; Clinical Relevance
Authors: T. Kianifard, A. Chopra
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Pain is multifaceted and difficult to capture. RAPS (Anderson D. Arthritis Care Res 2001; 45:317) was designed to measure physiologic, affective, sensory-discriminative, and cognitive aspects but so far finds sparse recognition. There are no gold standard pain instruments. Against this perspective, a suitable version was validated for use in our community. <h3>Objectives</h3> To validate an Indian version of RAPS for pain measure in RA <h3>Methods</h3> RAPS after suitable translation (contextual) was administered in face-face interview to 99 consenting active painful patients suffering from RA (ACR 1987 criteria; 93% women, mean age and disease duration 46.9 years and 8.7 months respectively, mean Pain VAS 5.3.; 76% seropositive RF) and on supervised rheumatology care in a popular community center. Standard of care medical documents captured the required data [included joint counts pain/swelling (JCPT/SW), patient &amp; physician global assess, Indian version HAQ, SF 36]. RAPS contained 24pain questions [score 0-6 per question, total 0-144; anchor scored 0 (never) and 6 (always].This was a cross sectional prospective design study but all patients were followed for 16 weeks in a 3 arm controlled dietary intervention study with MTX background; SPSS used for statistical analysis (significant "S" p&lt;0.05). <h3>Results</h3> RAPS showed good face and content validity. Other validity measures- Test-retest Cronbach9s Alpha =0.91 and overall good content and construct validity for total and individual domain score except for a low alpha for "affective domain"; Correlation Matrix (Pearson r):age 0.02, duration disease 0.16, JCPT 0.15, JCSW 0.06, patient global 0.14, ESR -0.04, CRP 0.06, pain VAS 0.30 (S) &amp; HAQ 0.30 (S). Pain VAS was the only significant predictor (multiple multivariable linear regressions). RAPS was found to load along with HAQ, pain VAS,JCPT and patient global (all patient centric)in the 'first' factor of the principle component "factor analysis" ;successive factors were lab and JCSW. Further data (construct and criterion/external validity) will be presented on (i) RAPS subscale analysis (ii)SF 36 physical &amp; mental scores analysis (iii)sensitivity to change (fair-moderate). Patient satisfaction was high and it seems to impact compliance. <h3>Conclusions</h3> RAPS is a valid and clinically relevant instrument to measure and monitor pain and response to treatment in patients of RA. It deserves to be recognized in rheumatology practice <h3>References</h3> Chopra, Saluja. Validation and usefulness of Indian version (CRD Pune) health assessment questionnaire: drug trials, community practice and COPCORD Bhigwan population study (1994-2012). Indian J Rheumatol 2012;7(2):74-82. <h3>Acknowledgements</h3> Patients, Management &amp; colleagues at CRD Pune and in particular Dr S Sarmukkadam, Dr N Kulkarni, Ms Manjit Saluja, Dr Anuradha V, Dr R Rane <h3>Disclosure of Interest</h3> None declared
NAIL BITING
Authors: JOEL MILAM HILL
Journal: American Journal of Psychiatry (1946)

Patients evacuated to a naval hospital in this country from the Pacific battle area because of nervous conditions, excluding psychoses and psychopathic personalities, were examined in regard to nail biting. From routine admissions, 100 nail biters were collected. The frequency of the condition was determined. By studying the personalities, service and combat reactions of these patients, an effort was made to throw some light on the personalities of nail biters and the military usefulness of those who bite their nails. A comparative study was made on 100 nail biters who had experienced combat, who had no sick list admissions because of nervousness, and who were separated from naval service by the point system.
BGB324 Represents an Axl and BCR-ABL1 Inhibitor with Activity in the T315I Mutant
Authors: Robert Erdmann, Heather Jorgensen, Isabel Ben-Batalla, Nils Kruse, David Micklem, Gunhild von Amsberg, Philippe Schafhausen, Alexander Schultze, Mark Wroblewski, Mascha Binder, Miguel Cubas-Cordova, Tobias Hadlich, Melanie Janning, Stefanie Sawall, Victoria Gensch, Elaine K Allan, Leena Mukherjee, Heather Morrison, Jennifer Cassells, Nicolaus Kroeger, James Lorens, Richard E. Clark, Steffen Koschmieder, Peter Vandenberghe, Tim H. Brümmendorf, Andreas Hochhaus, Peter Carmeliet, Tessa L. Holyoake, Klaus Pantel, Carsten Bokemeyer, Sonja Loges
Journal: Blood (2014)
Differential sensitivity of B-CLL cells and normal B cells to hyperthermia
Authors: D. Schoeler, C. Weber, A. Tornack, F. Schriever, F. Ringel
Journal: Journal of Clinical Oncology (2005)

6693 Background: Inhibition of apoptosis is a major cause why B-cell chronic lymphocytic leukemia (B-CLL) still can not be cured with conventional chemotherapy. Therefore, innovative approaches to this clinical enigma are needed. Whole body hyperthermia (WBH) as a part of a systemic Cancer Multistep Therapy (sCMT) is under investigation in a variety of advanced solid tumors. The aim of the current study was to examine whether B-CLL cells and normal peripheral lymphocytes have a differential sensitivity to hyperthermia in vitro. Methods: Peripheral blood B cells of patients with B-CLL (n=38) and normal donors (n=21) were isolated by Ficoll gradient centrifugation and were incubated in vitro at different temperatures (37–42°C) over defined time periods (15–300 minutes). Apoptosis and necrosis of anti-CD19-labelled B cells were quantified by Annexin-V-FITC and Propidiumiodide respectively, using flow cytometry. Nuclear fragmentation demonstrating apoptosis was visualized by DAPI-staining using fluorescence microscopy. Apoptosis via mitochondrial pathway was monitored by JC-1. Induction of cDNAs encoding for the heat shock proteins (hsp) 27, 60, 70, 90, and 105 was quantified using RT-PCR. Results: In B-CLL cells apoptosis was induced at 40°C and higher with an optimal temperature at 42°C. Induction of programmed cell death could be observed as early as after a 15 min incubation at 42°C. Interestingly, B-CLL cells differed in their ability to undergo heat-induced apoptosis from normal B-lymphocytes. After a 2 hour incubation at 42°C 56 ± 15% of all B-CLL cells but only 12 ± 9% of normal B cells underwent apoptosis (p<0,0001). Of note was, that in both, normal and malignant B-cells, heat-treatment induced hsp 27, 70, and 90. Interestingly, high hsp 27 levels in untreated CLL cells were shown to be positively correlated with hyperthermia induced apoptosis. Conclusions: B-CLL cells are more susceptible for heat-induced apoptosis than normal peripheral B cells. We hypothesize, that our data may encourage innovative studies examining whole body hyperthermia as an experimental approach to treat patients with B-CLL. No significant financial relationships to disclose.
Two Transplantable Rat Carcinomas Induced with N-Acetyl-2-Aminofluorene
Authors: H. P. Morris, Thelma B. Dunn, Celia S. Dubnik
Journal: JNCI Journal of the National Cancer Institute (1948)

Journal Article Two Transplantable Rat Carcinomas Induced with N-Acetyl-2-Aminofluorene Get access H. P. Morris, H. P. Morris Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn, Thelma B. Dunn Search for other works by this author on: Oxford Academic PubMed Google Scholar Celia S. Dubnik Celia S. Dubnik National Cancer Institute, National Institutes of Health, Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 3, December 1948, Pages 225–228, https://doi.org/10.1093/jnci/9.3.225 Published: 01 December 1948 Article history Received: 01 July 1948 Published: 01 December 1948
Mitral Insufficiency Simulating Aortic Stenosis
Authors: Russell Miller, R. J. Pearson
Journal: New England Journal of Medicine (1959)

CARDIAC lesions that produce signs like those of aortic stenosis usually have an actual physical similarity. Thus, the murmur and thrill of pulmonic stenosis are virtually indistinguishable from those of aortic stenosis, although their location and the relation of the components to the second sound differ slightly. Conversely, it is most unusual to find a seemingly unrelated lesion causing a hemodynamic situation reproducing the signs of aortic stenosis.Such a case has been reported by Osmundson, Callahan and Edwards. A "jet lesion" was found on the left atrial wall, closely approximate to the aortic valve. It was postulated that a . . .
Breast Cancer in Children
Authors: V F Semiglazov, G V Komov
Journal: New England Journal of Medicine (1961)

Cancer of the mammary gland in children is an extremely rare affection. According to the data of the N.N. Petrov Research Institute of Oncology among 6500 patients with breast cancer, treated clinically, cancer of the mammary gland in children was revealed only in three cases (0.046%). The clinical course and prognosis of mammary cancer in children is more favourable than in adults. A possibility of development of regional and distant metastases in mammary cancer in childhood warrants the need to perform adequate both local-regional (radical Holstead mastectomy) and general procedures (chemotherapy).
Biosynthesis and assembly of platelet GPIIb-IIIa in human megakaryocytes: evidence that assembly between pro-GPIIb and GPIIIa is a prerequisite for expression of the complex on the cell surface
Authors: A Duperray, A Troesch, R Berthier, E Chagnon, P Frachet, G Uzan, G Marguerie
Journal: Blood (1989)