tbuckley/cabot-search huggingface dataset:
PTH-120 Nursing Challenges of Implementing the Three Session Day
Authors: N J Taggart
Journal: Gut (2013)

<h3>Introduction Introduction:</h3> Three session working day in endoscopy was implemented at the Royal Liverpool hospital (RLH) in October 2009: in order to increase capacity as there was no room for estate expansion. The main drivers for this were increased projected activity from Bowel Cancer Screening and the increased waiting times. <h3>Methods Aim</h3> To discuss the nursing challenges when implementing three session days. <h3>Results Initial steps:</h3> The three session day provides 18 extra lists per week. The business case provided a comprehensive breakdown of what would be achieved by the three session day, why it was necessary, what this would mean for the patients and what it would mean financially for the trust. Workforce Challenges As nursing establishment increased, 10 WTE nursing staff/HCA, including one band seven Deputy Manager/Trainer. It is important that new staff are flexible. Workforce redesign, skill mix reviews, and altered contracts required careful negotiation and planning. Changing nursing rotas was a challenge as the new template did not marry well with traditional Monday –Friday 9–5pm nursing rotas. A creative and flexible approach to shift patterns was necessary, this allows maximum flexibility in rostering shifts but staff benefit from more time away from the department. Each staff member should be individually considered for each type of flexible working plan. It is important to robustly manage staff absence. <h3>Training Challenges</h3> A culture developed of staff only feeling confident to do certain procedures, thus limiting the skill mix across the department. It was realised that so many new starters and an expanded workforce required further investment in training. It is essential to have a senior nurse to focus on training. Since then a full training programme has been implemented providing clear guidance and structure to all staff. Support is also provided in weekly training sessions and cascade training. <h3>Leadership</h3> Steering a team through any organisational change required strong medical, managerial and nursing leadership, with key skills of problem solving, organisation, negotiation, and the ability to communicate the right messages to the team. Communication strategies include weekly activity meetings with the managers, senior nurses, admin manager and endoscopy leads. Monthly staff meetings, quarterly user group meetings, Glitch board, communication board and daily team brief were introduced to facilitate feedback and communication. <h3>Conclusions</h3> The three session day benefitted the department greatly by increasing much needed capacity when there was no room for expansion. It has been challenging and has only been successful through effective communication, a team approach and a commitment to achieving a common goal. <h3>Disclosure of Interest</h3> None Declared.
THROMBOSIS AFTER BIORESORBABLE VASCULAR SCAFFOLD IMPLANTATION: ANGIOGRAPHIC AND OCT FINDINGS
Authors: Serban Puricel, Florim Cuculi, Peiman Jamshidi, Zacharenia Kallinikou, Melissa Weissner, Thomas Muenzel, Stephane Cook, Tommaso Gori
Journal: Journal of the American College of Cardiology (2015)
Patient-Derived Tumor Xenografts
Authors: Edison T. Liu, Carol J. Bult, Leonard D. Shultz
Journal: JAMA Oncology (2016)

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AB1064 Characteristics of Patients with Inadequate Treatment Response According to the Rheumatologist's Assessment in the Course and Prognosis of Early Arthritis Cohort (CAPEA):
Authors: K. Albrecht, M. Chubrieva, J. Callhoff, E. Edelmann, M. Schneider, A. Zink, G. Westhoff
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> A certain proportion of patients with rheumatoid arthritis fail to respond to multiple DMARD therapies. Agreed measures of treatment response include joint involvement, acute phase reactants and patient and physician global assessments. Scores such as DAS28, ACR or EULAR response cover only certain dimensions of the disease whereas response as assessed by the rheumatologist may comprise further aspects under surveillance. <h3>Objectives</h3> To analyse which clinical parameters are associated with the rheumatologists9 assessment of response. <h3>Methods</h3> 662 patients with early rheumatoid arthritis (symptom duration 12±7 weeks) were followed for 2 years. Response to therapy was measured using standard scores as well as the rheumatologist9s global assessment (excellent/good/modest/poor). Outcomes were controlled for sex, age, serology, joint counts, patient-reported outcomes and physician-reported chronic conditions at baseline as well as use of therapies at 2 years and were bi- and multivariately associated with the response variable using ANOVA and logistic regression models. Patients reported functional capacity (FFbH, range 0-100% of full function), impact on quality of life according to the Rheumatoid Arthritis Impact of Disease Score (RAID) and Profile of Fatigue and Discomfort (PROFAD). <h3>Results</h3> 106 patients (16%) were assessed by the rheumatologists as having inadequate response (IR= moderate or poor). IR was associated with a significantly higher DAS28 at 2 years and a higher use of therapies. Patients with IR additionally reported significantly more frequent morning stiffness and rated the RAID, PROFAD and FFbH dimensions poorer than responders. IR was not associated with baseline DAS28 and comorbidities but with patient-reported baseline FFbH, PROFAD and RAID scores. Multivariate analyses of baseline parameters revealed younger age (OR 1.3 per 10 years) and impaired FFbH (OR 1.2 per 10% function loss) as significant predictors of IR. <h3>Conclusions</h3> The rheumatologist9s rating of IR was highly associated with clinical outcome at two years reflected by significantly higher DAS28 and intensive need of therapies as well as inferior patient-reported outcomes. Early functional impairment seems to be predictive of IR. <h3>Disclosure of Interest</h3> K. Albrecht Grant/research support: The observational cohort was funded by an unconditional grant from Pfizer., M. Chubrieva: None declared, J. Callhoff: None declared, E. Edelmann: None declared, M. Schneider: None declared, A. Zink: None declared, G. Westhoff: None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3559
Abstract 4341: Tumor imaging via β-galactosidase fragment complementation with a multifunctional targeted-reporter complex
Authors: Ann-Marie Broome, Kari Lavik, Gopalakrishnan Ramamurthy, Luther A. Liggett, Richard S. Agnes, James P. Basilion
Journal: Cancer Research (2010)

Abstract Determining the status of cell surface receptors has become routine in the care of patients with cancer and has proven to be helpful in guiding treatment. Mutational events that drive a normal cell to become a cancer cell require the coordinated overexpression of not just one receptor at a time, but rather multiple biomarkers. A growing body of evidence from genomic and proteomic research asserts that several receptors contribute to tumor behavior and these expression patterns are referred to as the cancer signature. Many cancers are characterized by an abnormal increase in the activity of epidermal growth factor receptors (EGFR) and transferrin receptors (TfR). Our data of representative human cancer cell lines demonstrate unique, observable expression patterns for the two receptors. Targeted-reporter imaging agent platforms have real application for noninvasive imaging of the multi-step progression of cancer growth, creating the next frontier in in vivo imaging. To develop imaging tools that take advantage of the diagnostic molecular signature, new technologies must employ a contrast agent or signal-amplifying material conjugated to a targeting agent. By linking a reporter enzyme, such as β-gal, to a targeting moiety, either ligand or a short peptide, signal-amplification at the molecular level is achieved. We divided β-gal into unique, independent polypeptides that reassemble and complement enzymatic activity in bacteria and in mammalian cells. We created two sets of complementing pairs that individually have no enzymatic activity. However, when brought into close proximity, complementing pairs associate, resulting in detectable enzymatic activity. We then constructed a targeting complex composed of reporter fragment, linker, and targeting moiety. Our studies demonstrate a time course- and dose-dependent uptake in vitro. Further, we were able to simultaneously visualize the two cell surface receptors implicated in cancer development, EGFR and TfR, using complementing pairs of the targeted-reporter fragment complex. In addition, we are able to image tumor localization in vivo of the targeted-complexes when a fluorescence reporter is added to the complex, as well as immunohistochemical staining of the β-gal reporter complex ex vivo. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4341.
Chagas' Heart Disease in the United States
Authors: James M. Hagar, Shahbudin H. Rahimtoola
Journal: New England Journal of Medicine (1991)

Chagas' heart disease is believed to be rare in the United States, although many persons from countries where the disease is endemic reside here. We performed a retrospective case review and prospective follow-up of 25 patients with Chagas' heart disease and no obstructive coronary artery disease on angiography.The patients mainly presented with symptomatic atrioventricular block, congestive heart failure, anginal chest pain, sudden death averted by resuscitation, or sustained ventricular tachycardia. Of the 25 patients, 18 had been treated for coronary artery disease or idiopathic dilated cardiomyopathy for up to 108 months before the diagnosis of Chagas' disease was considered. The electrocardiograms frequently suggested coronary artery disease. Six of the seven patients who had exercise thallium-perfusion scans had abnormalities suggesting ischemia or infarction. A left ventricular aneurysm was found in 14 of the 25 patients, segmental akinesia or hypokinesia in 5, and diffuse hypokinesia in 3. Programmed ventricular stimulation performed in 13 patients induced sustained ventricular tachycardia in 9 and nonsustained ventricular tachycardia in 2. Actuarial survival (mean +/- SE) after four years for the entire group was 56 +/- 12 percent; it was 32 +/- 16 percent among those with global left ventricular dysfunction, and 78 +/- 14 percent among those without such dysfunction (P = 0.03). Only patients with left ventricular dysfunction or an aneurysm died (four-year survival, 45 +/- 14 percent, as compared with 100 percent for the remaining patients; P = 0.0002). Heart failure and left ventricular aneurysm or dysfunction were the only independent predictors of death. Nine patients required permanent pacemakers.In the United States, Chagas' heart disease commonly mimics coronary artery disease or idiopathic dilated cardiomyopathy. The prognosis is poor for patients with heart failure or left ventricular aneurysm or dysfunction. The disease may be underdiagnosed in the United States.
Birth Outcomes in Pregnant Women Taking Fluoxetine
Authors: Christina D. Chambers, Kathleen A. Johnson, Lyn M. Dick, Robert J. Felix, Kenneth Lyons Jones
Journal: New England Journal of Medicine (1996)

Although fluoxetine is the most frequently prescribed antidepressant drug in the United States, its safety in pregnant women has not been established.From 1989 through 1995, we prospectively identified 228 pregnant women taking fluoxetine. We compared the outcomes of their pregnancies with those of 254 women identified in a similar manner who were not taking fluoxetine.The rate of spontaneous pregnancy loss did not differ significantly between the women treated with fluoxetine and the control women (10.5 percent and 9.1 percent, respectively), nor was the rate of major structural anomalies significantly different (5.5 percent vs. 4.0 percent). Among the 97 infants exposed to fluoxetine who were evaluated for minor anomalies, the incidence of three or more minor anomalies was significantly higher than among 153 similarly examined control infants (15.5 percent vs. 6.5 percent, P=0.03). As compared with the 101 infants exposed to fluoxetine only during the first and second trimesters, the 73 infants exposed during the third trimester had higher rates of premature delivery (relative risk, 4.8; 95 percent confidence interval, 1.1 to 20.8), admission to special-care nurseries (relative risk, 2.6; 95 percent confidence interval, 1.1 to 6.9), and poor neonatal adaptation, including respiratory difficulty, cyanosis on feeding, and jitteriness (relative risk, 8.7; 95 percent confidence interval, 2.9 to 26.6). Birth weight was also lower and birth length shorter in infants exposed fluoxetine late in gestation.Women who take fluoxetine during pregnancy do not have an increased risk of spontaneous pregnancy loss or major fetal anomalies, but women who take fluoxetine in the third trimester are at increased risk for perinatal complications.
Cancer Drugs Secure Speedy Approval in Canada
Authors: C. Vogt
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Cancer Drugs Secure Speedy Approval in Canada Get access Cheri Vogt Cheri Vogt Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 21, 4 November 1992, Pages 1620–1622, https://doi.org/10.1093/jnci/84.21.1620 Published: 04 November 1992
AB0444 Role of plasma cell analysis as a biomarker for disease activity in patients with granulomatosis with polyangiitis
Authors: B. F. Hoyer, A. Taddeo, M. Rothkegel, U. Schneider, G.-R. Burmester, A. Radbruch, F. Hiepe
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> B cells are important players in granulomatosis with polyangiitis (GPA) as suggested by the presence of autoantibodies reacting with specific neutrophil granular enzymes ANCA) in a vast majority of patients as well as the success of B cell depleting therapies in GPA. Renal manifestations in GPA are considered to be directly ANCA – mediated whereas the granulomatous inflammation appears to be mediated by CD4 T cells. <h3>Objectives</h3> For a better understanding of the possible role of B cells in ANCA-associated vasculitis we analyzed the B cell subsets in the peripheral blood of patients with GPA and found marked changes correlating with disease activity as measured by the BVAS (Birmingham vasculitis activity score) as well as ANCA-levels. <h3>Methods</h3> 17 patients with GPA (10 with active disease, 7 with inactive disease) were analyzed by flow cytometry as compared to 20 healthy donors. Staining for CD27, CD20, CD19, MHCII, CD3, 4 and 8 was analyzed using flowjo software. Statistical analysis was performed using graph pad prism, and p-values of &lt; 0,05 were considered as significant. The ethics committee of the Charité approved the study, and all patients had signed informed consent. <h3>Results</h3> Marked differences (p=0,0018) could be observed in plasma cell counts as well as frequencies in GPA patients (6,5 ±5,06/µl) with a BVAS-score &gt; 0 as compared to those with a BVAS-score =0 (2,5± 1,6/µl) or healthy persons (2,3±1,15/µl). Plasma cell numbers as well as the frequency of plasma cells within all B cells correlated with the BVAS (r= 0,91, p&lt;0,0001) as well as the ANCA-level in the serum (r= 0,83, p=0,0013). No significant differences could be observed for naive and memory B cells or the overall B cell numbers as compared to healthy donors. Regarding T cells, there was a significant reduction of CD3 (p=0,01) and CD4 T (p=0,012) cells in patients with active GPA as compared to patients in remission, whereas CD8 T cells did not show any significant changes. <h3>Conclusions</h3> Plasma cell numbers are increased in patients with active GPA which implies a role for plasma cell mediated effects in active GPA. Presumably, their main role is the production of autoantibodies, but also cytokine production. Independent of their direct contribution to the disease, they may serve as a biomarker of disease activity as they highly correlate with the BVAS. <h3>References</h3> Hoyer et al, ARD 2012 <h3>Disclosure of Interest</h3> None Declared
HLA and Disease
Authors: Miriam Segall, Fritz H. Bach
Journal: New England Journal of Medicine (1990)

The articles by Prochazka et al.1 and Baisch et al.2 in this issue of the Journal present information on associations of HLA alleles with disease. Prochazka et al. argue that it is one of the several linked loci of HLA that is most important in determining a patient's susceptibility to primary sclerosing cholangitis because an allele at that locus shows the highest association with the disease as measured by relative risk. Baisch et al. use allele-specific oligomer analysis of DNA sequences to define HLA polymorphisms related to particular amino acids to identify the most important associations between HLA and insulin-dependent . . .
IMPACT OF ECHOCARDIOGRAPHIC DIASTOLIC FUNCTION PARAMETERS ON THE RISK OF LEFT ATRIAL APPENDAGE: A PROSPECTIVE EVALUATION
Authors: Enrique D. Garcia-Sayan, Mita Patel, Marwan Wassouf, Rojina Pant, Saurabh Shah, Oliver D'silva, Richard Kehoe, Rami Doukky
Journal: Journal of the American College of Cardiology (2016)
Bony Metastases Seen on Scintigraphy with Samarium-153
Authors: NARESH VERMA, SURJIT SINGH-WADHWA, WAI-LING CHAN
Journal: Clinical Nuclear Medicine (2002)

VERMA, NARESH M.B.B.S.; SINGH-WADHWA, SURJIT F.R.A.C.P.; CHAN, WAI-LING F.R.A.C.P. Author Information
Abstract 4555: Remote sensing image dtection; a new tool for evaluation the tumor thickness in tongue SCC
Authors: Kuo-Wei Chang Chang, Yong Kie Wong, Mark Wong, Chein-I Chang
Journal: Cancer Research (2010)

Abstract A preoperative predictor of the risk of subclinical nodal metastasis would be useful. Studies have shown a strong correlation between histological tumor depth and the risk of nodal metastasis. To assess if preoperatively measured tumor depth predicts an increased risk of subclinical metastatic neck disease and thus the need for elective neck dissection. To further pin-point the boundary between normal to infective tissues, biopsy is generally performed. However, the similarity and the general nature of tissue substances between normal and cancer cells are sometimes hard to distinguish by human eyes. This is also true for experienced radiologist. Therefore, computer aided cancer cell classification is highly beneficial for such diagnoses. In this presentation, we implemented methods that are found highly successfully in satellite remote sensing image detection and classification. These methods can be grouped into two major categories, supervised and unsupervised classification. The supervised methods, Least Squares Orthogonal Subspace Projection (LSOSP), Non-negative Constraint Least Squares (NCLS) and Fully Constraint Least Squares (FCLS), require a detail library of every possible tissue signatures consist in the MR image. But, the classification results can be generally more accurate. On the other hand, the unsupervised methods, Automatic Target Detection (ATGP), Unsupervised Non-negative Constraint Least Squares (UNCLS), and Unsupervised Fully Constraint Least Squares (UFCLS), can automatically generate tissue classification results. However, parameters for these techniques such as the number of tissues need to be predefined. Also, the cancer cell classification still needs human intervention to justify the location of infectious region. Based on our experiments, both category of methods are show promising results. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4555.
High-flow nasal oxygen for bronchoalveolar lavage in acute respiratory failure patients
Authors: Béatrice La Combe, Jonathan Messika, Vincent Labbé, Keyvan Razazi, Bernard Maitre, Benjamin Sztrymf, Didier Dreyfuss, Muriel Fartoukh, Jean-Damien Ricard
Journal: European Respiratory Journal (2016)

Fiberoptic bronchoscopy with bronchoalveolar lavage (BAL) holds significant risks of oxygenation deterioration [1]. Among various means to improve oxygenation during BAL, noninvasive positive pressure ventilation (NPPV) has received the greatest attention [2, 3]. However, NPPV is a time-consuming and very demanding technique. High-flow nasal cannula oxygen therapy (HFNC) has emerged as a technique for noninvasive respiratory management of hypoxaemic patients [4]. In patients with acute respiratory failure (ARF), its beneficial effects have been shown in various populations [5], and its effectiveness and superiority over NPPV and conventional oxygenation recently demonstrated [6]. Its use has also been described during bronchoscopy in non-hypoxaemic [7] and in hypoxaemic patients in comparison with NPPV [8]. However, bronchoscopy was performed with an open mouth in both studies, which considerably reduces HFNC efficacy [9]. Thus, we aimed to determine HFNC's effectiveness during nasal bronchoscopy with BAL in patients with ARF along with BAL's feasibility and yield. HFNC is an effective and safe method of oxygenation during nasal bronchoscopy with BAL in hypoxaemic ARF patients <http://ow.ly/XAmtZ> Jonathan Messika, Muriel Fartoukh and Jean-Damien Ricard are members of the GREPI (French Group for Research and Education in Respiratory Infectious Diseases).