tbuckley/cabot-search huggingface dataset:
The Case Against Surgery as the Principal and Sole Means of Treating Varicose Veins of the Lower Extremity
Authors: R W STUEBNER
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Using Imatinib as Neoadjuvant Therapy in Dermatofibrosarcoma Protuberans: Potential Pluses and Minuses
Authors: Hillary Johnson-Jahangir, William Sherman, Désirée Ratner
Journal: Journal of the National Comprehensive Cancer Network (2010)

Dermatofibrosarcoma protuberans (DFSP) is an uncommon, low grade soft-tissue malignancy associated with a high risk for local recurrence and widespread subclinical extension. Imatinib, a selective tyrosine kinase inhibitor, has been a beneficial adjuvant therapy in patients with unresectable, recurrent, or metastatic DFSP. Because of its characteristic infiltrative growth, effective surgical excision of DFSP may be limited by the risk for disfigurement or functional impairment. In recent cases, neoadjuvant imatinib mesylate therapy has been shown to reduce preoperative tumor size and lessen surgical morbidity associated with the removal of residual DFSP. Use of neoadjuvant imatinib before surgery, however, requires appropriate patient selection and careful weighing of the potential risks and benefits of this treatment.
THERAPEUTICS XI
Authors: Heather Ashton, G. W. Beveridge, C. J. Stevenson
Journal: British Journal of Dermatology (1970)

Journal Article THERAPEUTICS XI Get access Heather Ashton, Heather Ashton Pharmacology Dept, University of Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar G. W. Beveridge, G. W. Beveridge Royal Infirmary Edinburgh Search for other works by this author on: Oxford Academic Google Scholar C. J. Stevenson C. J. Stevenson Royal Victoria Infirmary Newcastle upon Tyne Search for other works by this author on: Oxford Academic Google Scholar British Journal of Dermatology, Volume 83, Issue 2, 1 August 1970, Pages 326–330, https://doi.org/10.1111/j.1365-2133.1970.tb15710.x Published: 01 August 1970
PWE-240 Relationship between irritable bowel syndrome and chronic rhinosinusitis: a case control study
Authors: MM Darweesh
Journal: Gut (2015)

<h3>Introduction</h3> Irritable Bowel Syndrome (IBS) and Chronic Rhinosinusitis (CRS) are two of the most commonly reported complaints at health care systems and have a great negative impact on quality of life and health status of the population and actually related to many frustrating comorbidities, but there is not a clear relationship has been established between them before. Many people can suffer from both diseases without seeking medical care to know the underlying cause of their chronic illness, so this study is considered one of the turning points that assessed the relationship between both disorders, thus both physicians and patients could take that into consideration while dealing with either IBS or CRS complaints. <h3>Method</h3> In a case-control study design, a convenient sample of 133 medical students at Suez Canal University – Egypt, were involved. Fifty students were identified as cases with irritable bowel syndrome (IBS) diagnosis; using Rome III criteria, and 83 healthy students as controls. Both cases and controls were subject to an assessment of the history of chronic rhinosinusitis symptoms; using European Position Paper on Rhinosinusitis and Nasal Polyps (EP3OS) criteria. <h3>Results</h3> The study included 44 female students with IBS (88%) and 50 female students (60.2%) without IBS, while males represented 6 (12%) of IBS cases and 33 (39.8%) of controls [p = 0.001]. The results revealed a statistically significant association between IBS and CRS [p &lt; 0.001] with an odds ratio of 17.8 [95% CI: 4.9–64.2]. Stratified analysis was performed to adjust for gender [adjusted odds ratio = 16.5 [95% CI: 4.2–64.4]. No statistically significant difference in the mean age between case and control groups [mean age: 21.4 ± 1.47 and 21.7 ± 1.38 years, respectively]. <h3>Conclusion</h3> The study successfully concluded the presence of a relationship between IBS and CRS, and proved that the risk of a CRS patient getting IBS is about 17 times more than non CRS one getting IBS. All gastroenterologists and otolaryngologists and even general practitioners must be aware of the presence of this relationship and the possibility of the presence of CRS in a patient with IBS and the presence of IBS in CRS patient, So work-up for both disorders should be done in case of the presence of one of them to avoid the cumulative burden on the patient–s health and economic status. However, it should be investigated further to give a clue for management and prevention of these common health problems. <h3>Disclosure of interest</h3> None Declared.
Experimental Studies in Metal Cancerigenesis. IV. Cancer Produced by Parenterally Introduced Metallic Nickel
Authors: W. C. Hueper
Journal: JNCI Journal of the National Cancer Institute (1955)

Experimental Studies in Metal Cancerigenesis. IV. Cancer Produced by Parenterally Introduced Metallic Nickel Get access W. C. Hueper W. C. Hueper Environmental Cancer Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 1, August 1955, Pages 55–73, https://doi.org/10.1093/jnci/16.1.55 Published: 01 August 1955 Article history Received: 15 December 1954 Published: 01 August 1955
Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association (vol 69, pg 7393, 2009)
Authors: Hilde Brems, Caroline Park, Ophélia Maertens, Alexander Pemov, Ludwine Messiaen, Meena Upadhyaya, Kathleen Claes, Eline Beert, Kristel Peeters, Victor Mautner, Jennifer L Sloan, Lawrence Yao, Chyi-Chia Richard Lee, Raf Sciot, Luc De Smet, Eric Legius, Douglas R Stewart
Journal: Cancer Research (2009)
The Biosynthetic Preparation of C&lt;sup&gt;14&lt;/sup&gt;-Labeled &lt;italic&gt;N&lt;/italic&gt;-(1- and 3-Hydroxy-2-fluorenyl) acetamides, and Their Metabolism in Rats and Guinea Pigs&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: John H. Weisburger, Elizabeth K. Weisburger, Preston H. Grantham, Harold P. Morris
Journal: JNCI Journal of the National Cancer Institute (1959)

The C14-labeled ortho-hydroxylated metabolites of the carcinogen N-2-fluorenylacetamide, N-(1- and 3-hydroxy-2-fluoren-9-C14-yl)acetamides, were prepared by biosynthesis in the rat. The metabolism of these compounds was studied in rats and guinea pigs after intraperitoneal injection. A larger percentage of a dose of either compound was excreted in the urine than in the feces. In rats and guinea pigs, 60 to 75 percent, and 90 percent, respectively, of the urinary radioactivity was in the form of glucuronides. The injected 1-hydroxy compound was excreted in the urine by rats as the 1-hydroxy, the 1,5-dihydroxy, and the 1,7-dihydroxy derivative, whereas guinea pigs eliminated mostly the 1,7-dihydroxy compound. About 69 percent of the urinary radioactivity was found to be the 3-hydroxy derivative: 8 percent as the 3,5- and 9 percent as the 3,7-dihydroxy derivative after administration of the 3-hydroxy compound to rats. Guinea-pig urine included 47 percent of the 3-hydroxy and 38 percent of the 3,7-dihydroxy derivative. Radioactivity from both injected compounds was present in all rat tissues examined. More isotope was tightly bound to the proteins of rat liver after injection of the 1-hydroxy derivative than after N-2-fluorenylacetamide, whereas the 3-hydroxy isomer gave lower levels. The specific activity of guinea-pig liver proteins was lowest after N-2-fluorenylacetamide, and somewhat higher after the 1- and 3-hydroxy compound. These results are discussed in relation to the species differences found between rats and guinea pigs, especially in regard to the apparent resistance of the latter species to carcinogenesis by N-2-fluorenylacetamide.
Second primary malignancies in small-cell lung cancer: a major consequence of modest success.
Authors: D C Ihde, M A Tucker
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.10.1511 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1328546 Second primary malignancies in small-cell lung cancer: a major consequence of modest success. D C IhdexD C IhdeSearch for articles by this author , M A TuckerxM A TuckerSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.10.1511 First Page PDF © 1992 by American Society of Clinical Oncology
The dexamethasone suppression test in outpatients with primary affective disorder and healthy control subjects
Authors: J D Amsterdam, A Winokur, S N Caroff, J Conn
Journal: American Journal of Psychiatry (1982)

The authors report data on the overnight dexamethasone suppression test (DST) from 64 patients with primary affective disorder (41 unipolar, 17 bipolar-depressed, and 6 bipolar-hypomanic) and 53 healthy control subjects. No difference between the patients and controls was noted in baseline 8:00 a.m. serum cortisol levels or in cortisol levels obtained after the administration of 1 mg of dexamethasone. Sixteen patients and 8 controls had 4:00 p.m. postdexamethasone cortisol levels higher than 5.0 micrograms/dl. The distribution of suppressors and nonsuppressors did not differ significantly between the two groups. Patient nonsuppressors had significantly higher baseline cortisol levels than did patient suppressors (p less than .001). Clinical parameters and family history data did not distinguish patient suppressors from nonsuppressors.
FRI0628-HPR Survey on Awareness of Rheumatology Nurses for Eular Recommendations
Authors: M. Kaneko, S. Honjo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The “EULAR recommendations for the role of the nurse in the management of chronic inflammatory arthritis [1]” (hereinafter referred to as recommendations) were announced in 2012 and have become the guideline for rheumatology nurses. The American College of Rheumatology (ACR) also announced the role of nurses in 2013 [2]. Although the recommendations are adequately understood by nurses, they have not been fully practiced. It was suggested that doctors and patients expect that nurses will practice nursing care of rheumatism. On the other hand, such reports and surveys have not been conducted in Japan. <h3>Objectives</h3> To understand the current situation of nursing care of rheumatism and make clear future issues by conducting a survey on the level of consent and level of practice for the recommendations in Japan. <h3>Methods</h3> The survey was conducted using a questionnaire by mail or to be filled out at a lecture venue for rheumatology nurses. The questionnaires were made up of 10 items described in the recommendations and nurses were asked to fill out the level of consent and level of practice on a 5-point scale. <h3>Results</h3> The number of nurses who cooperated with the survey was 202. Of those, the results of questionnaires filled by 186 nurses without any inappropriate description were analyzed. The background of nurses in the analyzed questionnaires was as follows: (1) the history of rheumatology nursing care was &lt;3 years for 44.3%, ≥3 years and &lt;5 years for 23.3% and ≥5 years for 32.4%; and (2) the working form was 70.9% for working at hospital and 29.1% for working at clinic with no bed. The awareness level for recommendations was low at 16.6%. While the level of consent was very high at 90% or more to recommendations 2, 6, 8 and 9, it was low to recommendation 3. While the level of practice was highest at 50.5% for recommendation 8, it was low in the range of ≥10 to &lt;20% for recommendations 3, 7, 9 and 10. <h3>Conclusions</h3> The results of this survey demonstrated that the awareness level for recommendations was low in Japan, the level of consent was high and the level of practice was low, which indicated a gap between the ideal and the reality in rheumatology care as was the case with the results announced during the ACR2013. In order to make every rheumatology nurse aware of the recommendations in the future, it is considered necessary to clearly state and spread them at seminars, etc. for nurses with the cooperation of doctors. In order to improve the level of practice, the rheumatology nurses themselves need to be the source of information to educate nurses and practice the recommendations by creating a network of nurses. <h3>References</h3> Yvonne van Eijk-Hustings, et al. Ann Rheum Dis 2012;71:13–19. Brown, et al. Arthritis Rheum 2013;65 Suppl 10:2908 <h3>Disclosure of Interest</h3> None declared
Middle ear muscle activity during REM sleep in schizophrenic, schizoaffective and depressed patients
Authors: K L Benson, V P Zarcone
Journal: American Journal of Psychiatry (1982)

The authors measured the middle ear muscle activity during REM sleep of normal subjects (N = 13) and patients with schizophrenia (N = 11), schizoaffective disorder (N = 8), or major depressive disorder (N = 10). The rates of middle ear muscle activity for 5 schizophrenic patients were higher than the highest rates of the other groups. The patients with major depressive disorder had normal rates, and the rates of those with schizoaffective disorder were below normal. Within the schizophrenic patients, high middle ear muscle activity could not be directly attributed to background sleep disturbances, age, anxiety, depression, or diagnostic subtype.
SECTION OF DERMATOLOGY.
Authors: B SCHWARTZ
Journal: British Journal of Dermatology (1952)

British Journal of DermatologyVolume 64, Issue 2 p. 61-67 SECTION OF DERMATOLOGY President—Dr. W. N. GOLDSMITH First published: February 1952 https://doi.org/10.1111/j.1365-2133.1952.tb16163.xAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume64, Issue2February 1952Pages 61-67 RelatedInformation
SP0013 The Electronic Medical Record as a Research Resource
Authors: J.A. Jover
Journal: Annals of the Rheumatic Diseases (2015)

Information and Communication Technologies (ICT) have a great potential to improve safety, quality and efficiency of health systems. Electronic Health Records (EHR) are critical to create a technological health infrastructure, including the generation, storage and utilization of data to be used in research. However, quite frequently, EHRs functionalities are inconsistently aligned with the needs of patients, physicians and researchers. In order to fulfill the needs of the different users, HER9s must fully exploit the technical benefits of both Interoperability and the MVC (Model, View, Controller) Development Framework. An additional requirement is to define a Set of Core Data, essential for the management of patients, and to facilitate a high level of codification/parameterization in routine, addressing the needs and roles of health professionals. Using routine data, we will be able to advance to a Health Learning System in such important aspects as safety, effectiveness and health results, contributing to the Big Data promise. <h3>Disclosure of Interest</h3> None declared
Scientific imperialism
Authors: P. Wilmshurst
Journal: BMJ (1997)

This week the BMJ carries a debate on whether drug companies conducting clinical trials on patients infected with HIV in South Africa should continue to supply the drugs after the trial ends to the subjects who show benefit and who cannot afford to buy them (p 887).1 Dr Peter King of Roche Products concedes that subjects in clinical trials in Britain may be treated differently from those in Africa and South America (p 890). This inequality of treatment prompts other questions. Should research be conducted in a country where the people are unlikely to benefit from the findings because most of the population is too poor to buy effective treatment? Are poor people in developing countries being exploited in research for the benefit of patients in the developed world where subject recruitment to a randomised trial would be difficult?

The marketing policies of multinational drug companies proves that they do not treat developed and developing countries equally. The Medical Lobby for Appropriate Marketing, an international lobby group based in Australia, repeatedly criticises companies which market in developing countries drugs that are denied a product licence in the developed world …
Abstract 11178: Effect of Female Gender on Acute Coronary Syndrome Outcomes in Young Patients
Authors: Amar M Salam, Khalid AlHabib, Wael Almahmeed, Alawi Alsheikh-Ali, Kadhim Sulaiman, Haitham Amin, Ahmed Al-Motarreb, Jawad Al-Lawati, Nidal Asaad, Rajvir Singh, Jassim Al-Suwaidi
Journal: Circulation (2014)

Background: Recent reports have suggested that there are gender differences in the presentation of young adults with acute coronary syndromes (ACS). How these differences may affect ACS outcomes remains unclear, however. The aim of the current study was to examine the prognostic impact of gender in young adults with ACS in a multicenter multinational ACS registry from the Middle East. Methods: For a period of 9 months in 2008 to 2009, 7,930 consecutive patients with ACS were enrolled from 65 hospitals in 6 Middle East countries. A cohort of 3933 patients in the age group 55 years and younger were selected of whom 552 were women (14%). Gender differences in presentation and clinical features were examined. Multivariate analysis of in-hospital and one year mortality was also performed. Results: The mean age for women was 46 years and for men 48 years. Women had significantly higher rates of diabetes mellitus (50.4% vs. 30.7%), hypertension (57.4% vs. 34.5%), obesity (32% vs. 17%), dyslipidemia (37.5% vs. 26%) and renal impairment (4.1% vs. 1.2%) whereas men were more likely to be smokers (72.4% vs. 14%) [all P&lt;0.001]. Compared to men, women had an increased in-hospital and 1-year mortality rates (3.6% vs. 2.2%, p=0.04, and 9.7% vs. 6.5%, p=0.02, respectively). In multivariate analysis, female gender was an independent predictor of in-hospital mortality (OR, 1.88 [95%CI, 1.02-3.45]; P=0.04) and one year mortality (OR, 1.82 [95%CI, 1.18-2.78]; P=0.007). Conclusions: Our study shows that female gender independently and significantly increases the risk of immediate and long term mortality in young patients with ACS.
Medical Journals and Urgent Medical News
Authors: E J Huth
Journal: Annals of Internal Medicine (1983)

The Director of the Office of Health Policy Information in the Harvard School of Public Health, concerned with public anxieties about the acquired immunodeficiency syndrome, has urged scientific journals to take various steps to speed scientific information along, both to the news media and to print in the journals themselves. The Annals has for some years used one of these steps, accelerated peer review and revision of accepted papers. This journal also puts no constraints on authors discussing their research with the news media before publication of their papers. The journal, with authors' permissions, sends pre-publication copies of important papers to the Federal agencies with responsibilities related to those papers. The Department of Health and Human Services should consider setting up a clearinghouse that could receive such pre-publication copies and direct them to appropriate agencies. But none of these steps should by-pass peer review.
Case 3-1981: Leiomyosarcoma of Inferior Vena Cava
Authors: M Nagayoshi, K Umetsu, E Tanae, S Nishihara, K Ishibashi, N Ninomura, M Goto, K Mori, M Akagi
Journal: New England Journal of Medicine (1981)

Primary leiomyosarcoma of the inferior vena cava is rare and fatal. A 15-year-old female was admitted with the diagnosis of the right atrial myxoma associated with the Budd-Chiari syndrome. The tumor of the IVC was unresectable, although the right atrial tumor extended from the IVC was extirpated. Pathological examination of the tumor revealed a leiomyosarcoma. She was hemodynamically improved immediately after the operation. But she was expired due to the hepatic failure 9 days postoperatively. No autopsy was obtained. The literature regarding with leiomyosarcoma of the IVC was briefly reviewed.
Inheritance of Cancer of the Stomach and Large Intestine in Man2
Authors: Madge T. Macklin
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Inheritance of Cancer of the Stomach and Large Intestine in Man Get access Madge T. Macklin Madge T. Macklin Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 24, Issue 3, March 1960, Pages 551–571, https://doi.org/10.1093/jnci/24.3.551 Published: 01 March 1960 Article history Received: 26 June 1959 Published: 01 March 1960
Information processing dysfunction in paranoid schizophrenia: a two- factor deficit
Authors: D L Braff, D P Saccuzzo
Journal: American Journal of Psychiatry (1981)

The authors investigated information processing in schizophrenia by studying 30 paranoid schizophrenic patients and 30 depressed inpatients. The basic methodology relied on tachistoscopic presentation of stimuli. First, the critical stimulus duration needed for identification of a target stimulus was determined. Second, when the target stimulus was followed by a masking stimulus, a measure of speed of information processing was obtained. The schizophrenic patients were imparied on input factors and speed of processing. The authors think it is unlikely that the results were due to medication effect or to gross psychopathology. Their discussion centers on how this two-factor deficit in information processing may result in cognitive disruption and how this study relates to other investigations.
WHO to set up emergencies programme
Authors: Anne Gulland
Journal: BMJ (2016)

The World Health Organization will establish a health emergencies programme in response to widespread criticism over its handling of the Ebola epidemic in west Africa.1 WHO described the programme as one of the most “profound transformations” in its history. The organisation would take an operational role in emergencies, as well as its usual technical role.

WHO said in a statement, “The new programme was designed to deliver rapid, predictable, and comprehensive support to countries and communities as they prepared for, faced, or recovered from emergencies caused by any type of hazard to human health, whether disease …