tbuckley/cabot-search huggingface dataset:
The Mental and Nervous Disorder Utilization and Cost Survey: an analysis of insurance for mental disorders
Authors: O B Towery, S S Sharfstein, I D Goldberg
Journal: American Journal of Psychiatry (1980)

The Mental and Nervous Disorder Utilization and Cost Survey in Washington, D.C., has yielded useful information about outpatient utilization within an insurance plan with broad mental health coverage, as well as evidence that a comprehensive benefit with a low deductible and copayment can be offered and reasonably utilized. From the results of this survey and a substudy of claims made during 1977, the authors conclude that psychiatric diagnostic information submitted on insurance claim forms may often be inaccurate, primarily because of providers' concerns about confidentiality; such information is of little use for peer review or claims review. The authors state that caution must be exercised in generalizing from the experience under this plan to speculate about outpatient utilization which might result from broad coverage on a national level.
AB1021 Prevalence and Neuroimaging Correlates of Central Ataxia In Childhood-Onset Systemic Lupus Erythematosus
Authors: A.T. Lapa, R. Barbosa, I.N. Mendonça, M.C.F. Souza, F.A. Peres, R. Marini, L. Rittner, M. França, F. Bergo, F. Cendes, S. Appenzeller
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimune disease with fluctuating disease activity. Neurospichiatric manifestations are common and vary from common manifestations such as headache and anxiety to life threatening manifestations such as acute confusional syndrome. Ataxia has not been studied frequently in cSLE. <h3>Objectives</h3> To determine the prevalence of ataxia in cSLE and clinical, laboratory and treatment features associated with its occurrence. To determine neuroimaging features associated with ataxia, especially medullary area and cerebellar volume. <h3>Methods</h3> We included 62 cSLE patients followed at the State university of Campinas and 28 healthy controls with similar age and gender distribution. All patients and controls were evaluated for ataxia using Scale for the assessment and rating of ataxia (SARA), validated in portugues. All subjects realized magnetic resonance imaging using a 3 tesla scanner (Phillips). Sagittal T1 1mm thick slices were used for analysis. Medullary area and excentricity and cerebellar volume were analyzed using semiautomatic computer segemntation software (SpineSeg and Neuroline). <h3>Results</h3> We observed ataxia in 22 out of 62 (35.5%) patients and in none of the controls (p=0.002). Ataxia was associated with the presence of neuropsychiatric manifestations (p=0.003) and antifosfolipid antibodies (p=0.005). None of the other clinical, laboratory or treatment features were associated with ataxia. Medullary area was significant smaller in cSLE when compared to controls (p=0.002). Reduction of medullar area was associated with cumulative corticosteroid dose (r=-0.43; p=0.008) and the presence of ataxia (p=0.003). Cerebellar volume was significantly reduced in cSLE patients when compared to controls (p&lt;0.001). Cerebellar atrophy was associated with medullary area (r=0.46; p=0.001). None of the other clinical, laboratory and treatment features were associated with cerebellar volume. <h3>Conclusions</h3> Ataxia is frequently observed in cSLE and associated with neuropsychiatric manifestations and antiphospholipid antibodies. Neuroimaging features, especially medullary volume is associated with ataxia and cerebellar atrophy may be secondary. <h3>Disclosure of Interest</h3> None declared
Tardive dyskinesia in elderly psychiatric patients: a 5-year study
Authors: R Yassa, C Nastase, D Dupont, M Thibeau
Journal: American Journal of Psychiatry (1992)

The authors investigated the prevalence of tardive dyskinesia among elderly psychiatric patients who had never received neuroleptic medication before their first hospitalization.The study was performed in the geriatric psychiatry unit of a university-affiliated hospital in Canada and involved all first-admission patients admitted from September 1984 through August 1989 who had never taken neuroleptic drugs. In September and October 1989, the patients who were available for follow-up were examined and given ratings on the Abnormal Involuntary Movement Scale to establish the presence or absence of tardive dyskinesia. The patients' records were reviewed for information on age, diagnosis, duration of hospitalization, neuroleptic treatment received after admission, anticholinergic drugs received, and drug-free periods.Of the 162 patients who were available and whose data were analyzed, a total of 99 had been treated with neuroleptics, and 35 (35.4%) of these were found to have tardive dyskinesia. Two of the 35 also had tardive dystonia. Significantly more patients with major depression than patients with primary degenerative dementia or delusional psychosis had tardive dyskinesia.This study confirms the higher vulnerability of elderly psychiatric patients treated with neuroleptics to the development of tardive dyskinesia. The authors stress that caution is especially necessary when neuroleptics are prescribed for older patients with major affective disorders.
PTU-095 Dried blood spot testing for hepatitis C in community pharmacy – interim reporting of a quasi-experimental study of effectiveness
Authors: A Radley, J Tait, B Stephens, J Dillon
Journal: Gut (2015)

<h3>Introduction</h3> Low diagnosis rates for Hepatitis C (HCV) mean untreated progressive disease and ongoing infection. Up to 40% of service users on opioid replacement therapy (ORT) from pharmacies are infected. Audit demonstrates that only 2.5% of this estimated population is treated per annum. Stigma, travelling distance, confidentiality concerns and a lack of awareness of how to access testing, have been identified as barriers. For the ORT patients pharmacies offering dried blood spot testing (DBST) may overcome these barriers. This study compares uptake of testing in pharmacies offering DBST with testing from established routes, in a population receiving ORT. Established routes included general practice testing, testing in secondary care, testing in specialist drug services and testing in 3rd sector organisations. <h3>Method</h3> A quasi-experimental study design was used to compare non-randomly chosen intervention and control groups for access and uptake of DBST. Staff from 6 community pharmacies were trained to provide DBST and provided with a list of untested patients who could be invited to be tested. The list was constructed through a data linkage exercise joining the prescribing database for Tayside with the laboratory testing database using the community health index number (CHI). The pharmacies tested consenting patients during the last quarter of 2014. The primary outcome measure was the proportion of ORT service users accessing testing. Uptake was compared for patients accessing DBST in the 6 community pharmacies during the last quarter of 2014, compared to service users accessing HCV testing from any other service, for the 12 months of 2014. <h3>Results</h3> A total population of 1,339 patients were identified as being prescribed ORT in Dundee City of which 561 had no record of testing for HCV. During the 3 month period, 43 patients from the 6 community pharmacies accepted a DBST from a total of 143 eligible patients attending those pharmacies. Within the 561 eligible patients taking ORT across the whole of Dundee City, 75 patients were tested for HCV (30% Vs 13%). The OR for increased uptake of testing within the 6 pharmacies was 2.25 (95% CI 1.48 to 3.42, Z statistic = 3.81 p = 0.0001). The results from the DBST taken by the pharmacies showed 12 patients HCV+, 23 HCV negative, 7 DBSTs were not processed because of a missing ID number and 1 sample was a duplicate﻿. <h3>Conclusion</h3> This initial evaluation of DBST in community pharmacies found that a greater proportion of ORT service users took up the offer of a test, compared to the offer of a test from a wider range of providers, over a longer time period. This study shows that DBST in community pharmacies is both a feasible and effective method. <h3>Disclosure of interest</h3> None Declared.
Surgical Skill and Complication Rates after Bariatric Surgery
Authors: David Julià, Núria Gómez, Antoni Codina-Cazador
Journal: New England Journal of Medicine (2014)

To the Editor: Birkmeyer et al. (Oct. 10 issue)1 report that peer ratings of the technical skill of bariatric surgeons correlated with patient outcomes as measured according to complication rates — the higher the peer rating of technical skill, the lower the rate of complications. This finding may be true for laparoscopic bypass surgery performed by bariatric surgeons, but it may not hold true for other types of surgery. The study involved an operative procedure in which the technique is fairly standard. To suggest that the same findings may be observed in other procedures in which surgical approaches, techniques, and instruments vary significantly2,3 would be preliminary. Furthermore, although the authors use the term “surgeon,” there are considerable differences in the technical aspects of various surgical subspecialties.2 In rapidly advancing fields such as neurosurgery in which operative techniques are constantly changing,2,3 it is unclear whether peer ratings of technical skill are feasible, since variations in surgical technique are so diverse.
SP0184 Selecting the Best Journal for Communicating Research Findings
Authors: R. Bucala
Journal: Annals of the Rheumatic Diseases (2015)

The publication and dissemination of investigative findings are the final step in the scientific process and remain as critical as ever for the evaluation, broader discussion, and replication of scientific discoveries. Despite the explosion in new vehicles for publishing data, with greater speed, visibility, and options for scholarly journals, scientific findings nevertheless require careful organization into a formalized structure that permits facile and objective evaluation by peer reviewers. Significant time and preparation are required, and the selection of an appropriate journal is a key feature of this process. Herein, main points for the effective preparation and submission of scientific data to target journals is presented from the perspective of the Editorial Board of <i>Arthritis &amp; Rheumatology.</i> <h3>Disclosure of Interest</h3> None declared
Transplantation of HL-A Identical Allogeneic Bone Marrow to a Patient With Acute Lymphocytic Leukemia
Authors: ROBERT G. GRAW, JAMES A. BROWN, RONALD A. YANKEE, BRIGID G. LEVENTHAL, JACQUELINE WHANG-PENG, G. NICHOLAS ROGENTINE, EDWARD S. HENDERSON
Journal: Blood (1970)
Nanoparticulate Mineralized Collagen Scaffolds and BMP‐9 Induce a Long‐Term Bone Cartilage Construct in Human Mesenchymal Stem Cells
Authors: Xiaoyan Ren, Daniel W. Weisgerber, David Bischoff, Michael S. Lewis, Russell R. Reid, Tong‐Chuan He, Dean T. Yamaguchi, Timothy A. Miller, Brendan A. C. Harley, Justine C. Lee
Journal: Advanced Healthcare Materials (2016)

Engineering the osteochondral junction requires fabrication of a microenvironment that supports both osteogenesis and chondrogenesis. Multiphasic scaffold strategies utilizing a combination of soluble factors and extracellular matrix components are ideally suited for such applications. In this work, the contribution of an osteogenic nanoparticulate mineralized glycosaminoglycan scaffold (MC‐GAG) and a dually chondrogenic and osteogenic growth factor, BMP‐9, in the differentiation of primary human mesenchymal stem cells (hMSCs) is evaluated. Although 2D cultures demonstrate alkaline phosphatase activity and mineralization of hMSCs induced by BMP‐9, MC‐GAG scaffolds do not demonstrate significant differences in the collagen I expression, osteopontin expression, or mineralization. Instead, BMP‐9 increases expression of collagen II, Sox9, aggrecan (ACAN), and cartilage oligomeric protein. However, the hypertrophic chondrocyte marker, collagen X, is not elevated with BMP‐9 treatment. In addition, histologic analyses demonstrate that while BMP‐9 does not increase mineralization, BMP‐9 treatment results in an increase of sulfated glycosaminoglycans. Thus, the combination of BMP‐9 and MC‐GAG stimulates chondrocytic and osteogenic differentiation of hMSCs.
Section of Laryngology and Section of Otology: Combined Summer Meeting, May 31, June 1 and 2, 1928: Otological Session, June 2, 1928: Case of Vertigo on Suction in a Patient with Adhesive Processes in the Middle Ear, following Scarlet Fever: Presumably Malleo-Incudal Ankylosis
Authors: James Dundas-Grant
Journal: Journal of the Royal Society of Medicine (1928)
Coordinating ABNM Eligibility Within a Modified 48-Month Diagnostic Radiology Program
Authors: Adriana Faulkner, Pareen Mehta, Miriam Romero, Patrick M. Colletti
Journal: Clinical Nuclear Medicine (2015)

Faulkner, Adriana MD; Mehta, Pareen MD; Romero, Miriam MD; Colletti, Patrick M. MD Author Information
Soundings: Getting the hump
Authors: Trisha Greenhalgh
Journal: BMJ (2005)

If you cross our road, you can access five primary schools, two nurseries, a playground, and a home for elderly mentally infirm people. We used to have the best speed bumps in London: elegant little terracotta tables with gently sloping tarmac either side. Ninety-nine per cent of cars slowed down. Boy racers did predictable damage to their undercarriages. Nobody got killed.

The boy racers got together and lobbied the local council. They claimed that their civil liberties (the right to hit the accelerator when travelling down a residential road) were at stake. They presented a portfolio of “evidence,” downloaded from a US website calling itself “The rational motorists' guide to opposing speed bumps and other traffic obstruction strategies.” Apparently, speed bumps cause up to 250 000 deaths from sudden cardiac arrest, and hundreds of deaths from house fires. And that's not to mention all the bandits who escape while police cars are held up.

The original council committee was easily bought, since the boy racer evidence (despite the absence of a reference list) came with an American logo and was generously peppered with statistics. The council established what it called a “common sense” policy of removing speed bumps and then asking local residents if they minded. And when residents did mind, the council found it had run out of money.

The Medline database lists three meta-analyses of empirical trials of traffic calming measures. The largest, from the Institute of Transport Economics in Oslo, reviewed 33 primary studies and found that, overall, area-wide urban traffic calming schemes reduced the number of injury-related accidents by between 10% and 25%, with no discernible change in sudden cardiac deaths or deaths from house fires.

I took this evidence to a second council meeting. The chairman was unimpressed. He explained that the procedure on reinstating road humps was simple and non-negotiable: one vote for the residents of the road, one for the councillor for transport, one for the emergency services, and one for himself. Nobody could be required to read the research evidence before voting.

The boy racers are now lobbying traffic police—a group of young men self-selected for their enjoyment of exceeding the speed limit. So far, fortunately, only a cat has been killed.
Biological Testing of Sulfur Isosteres of Carcinogenic Hydrocarbons&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Susheela S. Waravdekar, Kamal J. Ranadive
Journal: JNCI Journal of the National Cancer Institute (1957)

Biological Testing of Sulfur Isosteres of Carcinogenic Hydrocarbons Get access Susheela S. Waravdekar, Susheela S. Waravdekar Department of Experimental Biology, Indian Cancer Research Centre, Parel, Bombay, India Search for other works by this author on: Oxford Academic PubMed Google Scholar Kamal J. Ranadive Kamal J. Ranadive Department of Experimental Biology, Indian Cancer Research Centre, Parel, Bombay, India Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 4, April 1957, Pages 555–567, https://doi.org/10.1093/jnci/18.4.555 Published: 01 April 1957 Article history Received: 29 October 1956 Published: 01 April 1957
Efficacy of urine monitoring in methadone maintenance
Authors: B Havassy, S Hall
Journal: American Journal of Psychiatry (1981)

To test the efficacy of screening urine specimens of methadone maintenance clients as a deterrent to illicit drug use, the authors randomly assigned 431 subjects to a monitored or an unmonitored group for 1 year. Monitored subjects continued to provide urine specimens once a week; unmonitored subjects did not. All other aspects of treatment remained the same. At 4 and 8 months after the study began, surprise urine collections were conducted. There was no difference between the groups in the proportion of drug-free specimens at either time.
Creatine phosphokinase, the MMPI, and psychosis
Authors: M E Faulstich, P J Brantley, C A Barkemeyer
Journal: American Journal of Psychiatry (1984)

The mean creatine phosphokinase level of 41 psychotic patients was significantly higher than that of 30 nonpsychotic psychiatric patients, as were their MMPI paranoia and schizophrenia scores. Their creatine phosphokinase level was negatively correlated with hysteria and psychopathic deviance.
Soundings: Goodbye and hello
Authors: Colin Douglas
Journal: BMJ (2005)

Quite a few years ago I went to hear a valedictory lecture by a retiring director of public health. No, really, I did. But please read on. It was fascinating, a crisp analysis of her 30 years in the business: optimism proved false, delusive complacency, and eventual nemesis—the stuff of tragedy.

When she joined, all the great infectious scourges of mankind—at least in their Scottish manifestation—had been conquered. Immunisation, better housing, and, of course, antibiotics, had vanquished the former horrors. And even tuberculosis had been overcome: by triple therapy, invented locally as it happens. To my delight the astonishing octogenarian behind it all was in the audience.

Then she read us a grim horoscope. Infectious disease was on the march again: AIDS, obviously; viruses exotic and variant; TB resurgent; and the iatrogenic epidemic of our day, hospital acquired infection.

I worry still about it all, but know most about the last. I see it every day: elderly women reduced to faecal incontinence for the first time in 90 years by Clostridium difficile; patients who have heard vaguely of methicillin resistant Staphylococcus aureus (MRSA), find they have it, and come to regard themselves as 21st century lepers; and a whole new eruption of threat—signified by suspicion, isolation, and stigma—that complicates care, impedes rehabilitation, delays return home, and kills people.

It's getting personal. A few years ago I slogged through a ward round that encompassed in considerable numbers C difficile, MRSA, and a minor epidemic of norovirus. It was the only time in my professional life that I felt like washing my hands before I went to the toilet.

But what are we to do? Frankly, even if we really knew—in the modern sense of having an evidence base—we probably wouldn't be able to do it. The bubbling cauldron of hospital acquired infection is the acute sector: crowded, dispirited, and scarcely able to respond; with most of its patients old and hence more susceptible and more likely to suffer greatly, though still far less likely to complain.

But some of them know what's going on: as a fine, vintage Edinburgh spinster who had survived both MRSA and C difficile put it to me, in the genteel, decisive tones of the late Miss Jean Brodie, “I'm going home to my own house. I keep it very clean. And there are no germs.”
Establishment and characterization of imatinib-resistant xenograft models of human gastrointestinal stromal tumor in mice.
Authors: Song Zheng, Ke-er Huang, Yao Zhou, De-you Tao
Journal: Journal of Clinical Oncology (2015)

e21508 Background: Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors which express KIT in gastrointestinal tract or abdominal cavity and appear to be the most common mesenchymal neoplasm of the gastrointestinal tract. The majority of GISTs are known to have gain-of-function mutations in KIT and PDGFRA.Imatinib currently becomes a model as a targeted therapy for locally advanced or metastatic GIST. However, patients with GIST may develop resistance to imatinib after a median of almost 24 months’ treatment. The aim of this study was to establish human xenograft nude mouse models of gastrointestinal stromal tumor (GIST) using imatinib-resistant cell lines, and identify the morphological and immunohistochemical characteristics of models which might provide an excellent experimental platform for further clarifying the possible mechanisms of the resistance to imatinib mesylate. Methods: GIST-R, GIST-PR1, and GIST-PR2 cell lines were implanted under the skin of nude mice to establish the xenograft models, separately. CD117, desmin and myogenin expression was evaluated using immunohistochemistry assay, and KIT and PDGFRA mutation was further investigated. Results: The imatinib-resistant xenograft nude mouse models of human GIST were successfully established. These mutation types observed in the models were in agreement with mutation results of GIST cell lines before implantation. Immunohistochemical results showed that CD117-positive expression was detected in GIST-PR2 xenograft model, while CD117-negative expression was observed in the GIST-R xenograft model. GIST-PR1 xenograft model exhibited mixed cell morphology, and rhabdomyosarcomatous differentiation was observed in some areas. The rhabdomyosarcomatous components showed CD117-negative expression, whereas showed positive expression of desmin and myogenin. Conclusions: Three imatinib-resistant xenograft nude mouse models of human GIST were successfully established, however, they exhibited some different histopathological and immunohistochemical features from the conventional GIST tissue. This xenograft model may be useful for further studying the imatinib-resistance mechanisms of GIST.
The Partition of Radiophosphorus (P&lt;sup&gt;32&lt;/sup&gt;) in Blood, Urine, and Tumor Tissue in Patients with Hodgkin's Disease and Lymphosarcoma before and after Treatment with Nitrogen Mustard [Methyl Bis (Beta-Chloroethyl) Amine]
Authors: S. P. Masouredis, B. V. A. Low-Beer, H. R. Bierman, L. S. Cherney, M. B. Shimkin
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article The Partition of Radiophosphorus (P32) in Blood, Urine, and Tumor Tissue in Patients with Hodgkin's Disease and Lymphosarcoma before and after Treatment with Nitrogen Mustard [Methyl Bis (Beta-Chloroethyl) Amine] Get access S. P. Masouredis, S. P. Masouredis Search for other works by this author on: Oxford Academic PubMed Google Scholar B. V. A. Low-Beer, B. V. A. Low-Beer Search for other works by this author on: Oxford Academic PubMed Google Scholar H. R. Bierman, H. R. Bierman Search for other works by this author on: Oxford Academic PubMed Google Scholar L. S. Cherney, L. S. Cherney Search for other works by this author on: Oxford Academic PubMed Google Scholar M. B. Shimkin M. B. Shimkin Laboratory of Experimental Oncology, National Cancer Institute, National Institutes of Health, U. S. Public Health Service, and the Departments of Medicine, Radiology, and Surgery, University of California School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 2, October 1950, Pages 289–300, https://doi.org/10.1093/jnci/11.2.289 Published: 01 October 1950 Article history Received: 12 June 1950 Published: 01 October 1950