tbuckley/cabot-search huggingface dataset:
Abstract 1870: Genotype polymorphisms of DNA repair genes interact with estrogen exposure to breast cancer susceptibility
Authors: Chun-Wen Cheng, Jyh-Cherng Yu, Hsiao-Wei Wang, Chia-Ni Hsiung, Shian-ling Ding, Pei-Ei Wu, Cheng-Wen Wu, Chen-Yang Shen
Journal: Cancer Research (2010)

Abstract Endogenous estrogen is suggested to initiate cell proliferation and cause oxidative DNA damage during breast tumorigenesis. Cells eliminate DNA damages by repair enzymes. Genotypic variants of DNA damage repair genes, participating base excision repair (BER) and nucleotide excision repair (NER) pathways, may act as modifiers that affect the association between estrogen exposure and breast cancer. In a hospital-based case-control study of female breast cancer, DNA samples from 401 cases and 533 healthy controls were enrolled among Chinese women in Taiwan. Genotyping polymorphisms of XRCC1 (Arg194Trp and Arg399Gln), OGG1 (Ser326Cys and Arg229Gln), ERCC2 Lys751Gln, ERCC4 Pro662Ser, and ERCC5 His1104Asp were determined and used to evaluate breast cancer susceptibility. Of these non-synonymous polymorphisms, ERCC5 1104Asp variant was significantly associated with breast cancer (OR=1.42; 95%CI=1.08-1.97), and this was more pronounced in women with prolonged estrogen exposure. A trend toward an increased risk of developing breast cancer was observed in women who carried greater numbers of combined high-risk genotypes of BER and NER genes (Ptrend = 0.038). The synergistic effect of multiple genes on risk elevation was significant in women having a longer period of estrogen exposure (&amp;gt;26 years), a longer menarche-to-FFTP interval (&amp;gt;11 years), greater age at the first full-term pregnancy (&amp;gt;26 years), and higher body mass index (&amp;gt;22) (all P&amp;lt;0.05). In conclusion, this study demonstrates that genotype polymorphisms for the DNA damage repair confer higher risk in individual susceptibility to endogenous estrogen on female breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1870.
Alternating Drug Combinations in the Treatment of Advanced Hodgkin's Disease
Authors: Armando Santoro, Gianni Bonadonna, Valeria Bonfante, Pinuccia Valagussa
Journal: New England Journal of Medicine (1982)

Of 75 consecutive patients with Stage IV Hodgkin's disease, we assigned 38 to receive MOPP alone (mechlorethamine, vincristine, procarbazine, and prednisone) and 37 to receive MOPP alternating monthly with ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) — a combination of drugs not cross-resistant with MOPP. Complete remission was documented in 71 per cent of the patients receiving MOPP alone and in 92 per cent of those receiving the alternating regimen (P = 0.02). At five years, there was no progression of disease in 37 per cent of the MOPP group and in 70 per cent of the MOPP-plus-ABVD group (P<0.0001). After chemotherapy, the median relapse-free survival period was 20 months in the MOPP group and over 31 months in the MOPP-plus-ABVD group (P<0.01). Five-year survival with no evidence of disease was 84 per cent in patients given MOPP and ABVD and 54 per cent in those given MOPP alone (P<0.005). We conclude that alternating non-cross-resistant combinations appear promising in the management of advanced Hodgkin's disease and are worthy of trial in other malignant diseases. (N Engl J Med. 1982; 306:770–5.)
30Computational prediction of miRNA signature related to valvular heart disease with atrial fibrillation using coherent data sources at different molecular levels
Authors: W Feng, N Rao, BY Li, DY Liu, F Yang, HM Liu, X Chen
Journal: Cardiovascular Research (2014)

Purpose: Patients who have both atrial fibrillation and valvular heart disease (AF – VHD) are at a greater (17.5-fold) risk for stroke. MiRNAs, a class of short noncoding RNA controlling gene expression, participate in many physiological processes. This study takes the advantage of published data and results for a short-cut leading to rapid identification of AF-VHD-regulating miRNAs.
162 IMPACT OF BASELINE STEATOSIS AND SEVERITY OF ISCHAEMIA–REPERFUSION INJURY IN PREDICTING HCV RECURRENCE POST TRANSPLANTATION
Authors: D. Joshi, A. Quaglia, N. Heaton, C. Oliveira, M. Alvares-da-Silva, A. Sanchez-Fueyo, K. Agarwal, M.A. Heneghan
Journal: Journal of Hepatology (2013)
Intraductal US findings of perihilar biliary obstruction caused by hepatocellular carcinoma
Authors: JH Moon, SG Kim, YK Cheon, YD Cho, JW Joo, KW Kwon, YS Kim, JS Lee, MS Lee, HK Lee, CS Shim, BS Kim
Journal: Endoscopy (2006)

Background/Aim: Perihilar biliary obstructions caused by hepatocellular carcinoma (HCC) are rare and can be frequently misdiagnosed as cholangiocarcinoma on cholangiogram before histological confirmation. The aim of this study was to identify intraductal US (IDUS) features of HCC invading the perihilar biliary tree to differentiate from cholangiocarcinoma. Methods: Between 1998 and 2005, twelve patients (mean age; 61.2 years, men; 9) who underwent wire guided IDUS with suspicious malignant perihilar biliary obstruction had histological evidence of HCC. IDUS was performed with a catheter US probe (diameter, 2.0mm; frequency, 20MHz) via the transpapillary route. IDUS findings were retrospectively reviewed by consensus. Results: 1) IDUS was successfully performed in all patients, without sphincterotomy. 2) IDUS showed a completely filling, polypoid tumor without ductal wall change and tumor base in all patients. 3) The findings of a positive nodule in a nodule (75%), the smooth surface pattern (91.6%), and iso or low echogenicity (83.3%) were frequently associated with HCC invading bile duct. 4) Two of six patients underwent transpapillary fluoroscopic bile duct biopsy showed HCC on histologic examination. Conclusion: Intraductal US features may help in the differentiation of HCC from intraductal cholangiocarcinoma in the patients with perihilar biliary obstruction.
INFLUENCIA DE LA EXPERICIENCIA DEL ENDOSCOPISTA EN EL VALOR PREDICTIVO NEGATIVO DE LA CÁPSULA ENDOSCÓPICA
Authors: N Alcaide, B Velayos, L Fernández, R Aller, G González, C Tafur, E Berroa, A Macho, S Lorenzo, JM González
Journal: Endoscopy (2014)

Introducción: La experiencia mínima establecida para alcanzar competencia en la interpretación de la cápsula endoscópica (CE) es variable.
SAT0052 TNFγ adherent BM-DC efficiently inhibit collagen-induced- arthritis, and delayed skin graft rejection in mouse
Authors: L. Brikci-Nigassa, J.-L. Touraine, P. Miossec, A. Eljaafari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic inflammatory disease, initiated by a break in self-tolerance. Tolerogenic dendritic cells (Tol-DC) are involved in the maintenance of tolerance to antigen, but are deficient in RA. <h3>Objectives</h3> Our ultimate objective is to use Tol-DC for the treatment of patients with severe refractory RA. Therefore, in this project, we aimed to validate this approach by evaluating the therapeutic action of Tol-DCs in a type II collagen-induced arthritis murine model <h3>Methods</h3> We have previously reported that DC mediated by IFNg plus GM-IL4 are tolerogenic in human (1). Herein, mouse Tol-DC were prepared by using this protocol, except that bone-marrow mononuclear cells were used instead of blood monocytes. Arthritis was induced with 100 μg of type II collagen in 8–10-week-old DBA/1 mice, following two steps of sensitization and induction. Allogenic skin transplantation was performed by using Balb/c mice, which received skin graft from DBA/1 mice, after sublethal irradiation <h3>Results</h3> In contrast to human, IFNγ-treated DC did not resist to maturation in mouse, but died, probably by exhaustion. Moreover, treatment of bone marrow cells with GM-IL4 resulted in the appearance of adherent DC in mouse, but not in human Maturation of mouse adherent-DC with TNFa induced them to exert tolerogenic properties, <i>in-vitro</i>. <i>In vivo</i>, those cells inhibited collagen induced arthritis (p&lt;0.01, at D57, and D65), following their intra-peritoneal injection at the concentration of 2×10<sup>5</sup>, at the time of induction with collagen. Such induction of tolerance was confirmed in a skin graft mouse model, where rejection was delayed from day 8.5 to day 14.7, following only one injection of TNFa-adherent DC. <h3>Conclusions</h3> We demonstrate herein that TNFa-adherent DC are endowed with efficient tolerogenic properties in mouse, but point out major differences between mouse and human in the generation of Tol-DC. Indeed, GM-IL4 induced the appearance of adherent BM-DCs in mouse but not in human, whereas IFNg induced Tol-DC in human, but not in mouse. These results underline thus the difficulties to predict the beneficial effects of such cell therapies in human, by using rodent studies. <h3>References</h3> Assia Eljaafari; Yin-Ping Li; Pierre Miossec. J.Immunol: 2009;183:2932-45. <h3>Disclosure of Interest</h3> None Declared
Abstract C31: Identification of causal genetic events in oral cancer progression
Authors: Shevaun E. Hughes, Ivy F. L. Tsui, Catherine Poh, Cathie Garnis
Journal: Cancer Research (2009)

Abstract Background: Oral cancer is one of the world's leading causes of cancer death, with late stage disease diagnoses and high rates of recurrence accounting for poor survival rates. Like many solid tumors, oral cancer develops through a series of histopathological stages from dysplasia, to carcinoma in situ (CIS), to invasive disease. Escalating genomic instability and the accumulation of critical gene alterations is thought to drive disease progression. Causal gene changes remain to be identified for oral cancer. The objective of this study is to determine the essential gene alterations underpinning oral cancer progression. Hypothesis: Since cancers arise through the accumulation of genetic alterations, gene changes detected in the earliest stages of disease are the foundation of observed cancer phenotypes and essential for oral tumorigenesis. Experimental Approaches: Oral premalignant lesions and tumor samples were obtained from the Oral Biopsy Service of British Columbia and are associated with well annotated patient information (including disease outcomes). High resolution tiling-path array comparative genomic hybridization was used to define segmental DNA changes for each sample. Recurring regions of DNA alteration detected in premalignant lesions known to progress and preserved in later stage disease were flagged as critical events. Our list of candidate genes within these regions will be refined by analysis of publicly available genomic and gene expression data from oral tumors. Results: Whole genome copy number profiles from over 100 oral lesions and tumors have been successfully generated using array comparative genomic hybridization. From this data we have identified several molecular subgroups associated with initiation and progression of oral cancer. Significance: With knowledge of the key genes fueling oral tumorigenesis, we will be able to derive novel biomarkers capable of predicting disease behavior as well as gain a better understanding of the molecular pathways and gene networks responsible for driving oral cancer progression. Citation Information: Cancer Res 2009;69(23 Suppl):C31.
DOES CALCIUM BURDEN IMPACT ON CULPRIT LESION MORPHOLOGY AND CLINICAL
Authors: Peiren Shan, Gary Mintz, Bernhard Witzenbichler, Christopher Metzger, Michael Rinaldi, Peter Duffy, Giora Weisz, Thomas Stuckey, Bruce Brodie, Ke Xu, Ajay Kirtane, Gregg Stone, Akiko Maehara
Journal: Journal of the American College of Cardiology (2015)
The New Medical-Industrial Complex
Authors: Arnold S. Relman
Journal: New England Journal of Medicine (1980)

The most important health-care development of the day is the recent, relatively unheralded rise of a huge new industry that supplies health-care services for profit. Proprietary hospitals and nursing homes, diagnostic laboratories, home-care and emergency-room services, hemodialysis, and a wide variety of other services produced a gross income to this industry last year of about $35 billion to +40 billion. This new "medical-industrial complex" may be more efficient than its nonprofit competition, but it creates the problems of overuse and fragmentation of services, overemphasis on technology, and "cream-skimming," and it may also exercise undue influence on national health policy. In this medical market, physicians must act as discerning purchasing agents for their patients and therefore should have no conflicting financial interests. Closer attention from the public and the profession, and careful study, are necessary to ensure that the "medical-industrial complex" puts the interest of the public before those of its stockholders.
Endoscopic Ultrasonography-Guided Implantation of Iodine 125 Seeds in the Treatment of Unresectable Carcinoma of Pancreas
Authors: Z Jin, Z Li, Y Liu, Y Du
Journal: Endoscopy (2006)

Objective: To introduce the procedures and evaluate the clinic value of endoscopic ultrasonography-guided interstitial implantation of iodine 125 seeds in pancreatic cancer. Methods: Ten cases patients with pancreatic cancer underwent endoscopic ultrasonography-guided interstitial I seeds implantation. All patients were scanned on EUS, needle, and iodion seeds were used. The 125I seed was implanted with 19G needle and mick-gun during procedure. First of all, according to the size of tumor, the optimal quantity of seeds were calculated. Then, under the guidance of endoscopic ultrasonography, iodion seeds were implanted into the tumors for interstitial radiotherapy. CT follow-up examinations were performed one month after the therapy. The mean number of 125I seed ranged from 4 to 12 and the activity per seed ranged from 0.4 to 0.6mCi. Results: After procedure, relief of pain was obtained in 9 cases from 1 to 3 days. Patients were followed-up for 1 month, partial relief was obtained in 4 cases. In one case the pancreatic cancer decreased in size obviously (PR), in 6 cases the cancer size did not changed, 2 cases were progressive. Such complications as gastrointestinal tract bleeding, pancreatic fistula and pancreatitis were not found. Conclusion: Endoscopic ultrasonography-guided implantation of iodine 125 seeds in pancreatic cancer was a safe, reliable, and effective curative method for pancreatic cancer.
FRI0450 The need for a cross-sectorial approach to facilitate work and social participation of women with rheumatoid arthritis
Authors: B. Prodinger, L. Shaw, D. Laliberte-Rudman, T. Stamm
Journal: Annals of the Rheumatic Diseases (2013)

Background Despite significant advancements toward early and comprehensive treatment for people with rheumatoid arthritis (RA) over the past couple of decades, people with RA are still likely to experience pertinent limitations in their work and social participation, and have to adapt and adjust to a life with a chronic disease. The limitations have not only impact on the individual, but also on society. The societal impact points to direct costs for comprehensive treatment, and indirect costs due to work-absenteeism and invalidity. Objectives One of the study objectives was to disclose the intersection of arthritis-related health care and labor-market related services as relevant for Austrian women with RA, who are of employable age. Methods An institutional ethnography was conducted that allows mapping out relations that rule organizational practices. Multiple methods (interviews, participant observations, and textual analysis of hospital records and agreements of individuals with the labor market office) were used for data collection. Analysis was performed in two stages: first, a comprehensive account about what women actually do at the conjunction with service providers in arthritis-related health care and at the labor market office; secondly, texts that mediate these interactions were analyzed to understand concepts that rule these interactions. Results Seven Austrian women with RA, aged between 28 and 41, and varying working and living conditions were recruited for this study. The interaction in arthritis-related health care is ruled by biomedical concepts and categories. This has historically grown out of a diagnostic-related group model for funding health care. On the other hand, employment-related matters are dealt with at the labor market office and are ruled by concepts related to eligibility of benefits based on previous records of employment, employability, and willingness to work. In particular the chronic and fluctuating nature of RA is inadequately addressed by concepts of employability. Separation of health care and labor-market related services is characterized by different administrative and conceptual approaches: namely a focus on disease in health care and on employability in labor-market related services that may lead to social and participation disparities for women with RA. Conclusions More effort is needed to bridge the structural issues that challenge women with RA to navigate the health and labor systems and to manage health and equitably participate in work life. As exemplified by this study, a cross-sectorial approach in research and practice becomes increasingly important to fully facilitate work and social participation of people with RA who are of employable age. Disclosure of Interest None Declared
Aortic stiffness and ProBNP are increased at term and 6 months after pre-eclamptic pregnancy
Authors: Mette-Elise Estensen, Espen Remme, Guro Grindheim, Abigail Swillens, Lars Gullestad, Otto A Smiseth, Tore Henriksen, Patrick Segers, Svend Aakhus
Journal: Circulation (2010)
P2-11-11: IGFBP Ratio Confers Resistance to IGF Targeting and Correlates with Increased Invasion and Poor Outcome in Breast Tumors.
Authors: MA Becker, X Hou, SC Harrington, JM Carboni, MM Gottardis, P Haluska
Journal: Cancer Research (2011)

Abstract Purpose: To assess the role of insulin-like growth factor binding protein 5 (IGFBP-5) as a marker of relapse and survival in breast cancer tumors. Experimental Design: Targeted regulation of IGFBP-5 was identified in MCF-7 cells resistant (MCF-7R4) to the IGF-1R/InsR inhibitor, BMS-536924 and examined by comparative microarray analysis, western and ELISA. Protein expression of IGFBP-5 was measured by immunohistochemistry in a cohort of 84 breast cancer patients to examine correlative associations with invasive tumor fraction and overall survival (OS). The expression ratio of IGFBP-5/IGFBP-4 (BPR) was determined in multiple breast tumor cohorts for univariate analysis. Results: IGFBP-5 was markedly upregulated and highly localized to the membrane in MCF-7R4 resistant cells. When compared to pathologically normal reduction mammoplasty tissue, IGFBP-5 expression levels were upregulated in both invasive and histologically normal adjacent breast cancer tissue. In an independent cohort of breast cancer patients, IGFBP-5 protein levels correlated directly with invasion and OS. In univariate and multivariate modeling, metastasis-free survival, recurrence free survival (RFS) and OS were significantly associated with high IGFBP-5 expression. Prognostic power of IGFBP-5 was further increased with the addition of IGFBP-4 and tumors were ranked based upon IGFBP-5/IGFBP-4 expression ratio (BPR). Multiple breast cancer cohorts confirm that BPR (high vs. low) was a strong predictor of RFS and OS. Conclusion: IGFBP-5 expression is a marker of poor outcome in breast cancer patients. An IGFBP-5/IGFBP-4 expression ratio may serve as a surrogate biomarker of IGF pathway activation and predict sensitivity to IGF-1R-targeted therapies. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-11-11.
Abstract 4088: Targeting glutamine metabolism in breast cancer
Authors: Preethi C. Korangath, Huafeng Zhang, Zhe Zhang, David Huso, Vered Stearns, Chi Dang, Gregg Semenza, Saraswati Sukumar
Journal: Cancer Research (2011)

Abstract Background: Unlike normal cells, most cancer cells primarily metabolize glucose by glycolysis rather than oxidative phosphorylation (Warburg effect). The cancer cells are reprogrammed to acquire these fundamental metabolic alterations during malignant transformation via different mechanisms. These mechanisms include mitochondrial defects and malfunction, adaptation to a hypoxic tumor microenvironment, oncogenic signaling, and abnormal expression of metabolic enzymes. Cancer cells also rely on glutamine for anabolism and ATP synthesis. Recent studies have shown that inhibiting glycolytic pathways leads to a significant inhibition of growth of tumor xenografts. Our group has previously shown the MYC oncogene activates glutamine metabolism which serves as a major energy source in transformed cells. Objective: Examine the antitumor effect of a glutamine metabolic inhibitor, aminooxyacetate (AOA; aminotransferases/malate-aspartate shuttle inhibitor), alone and in combination with chemotherapy (doxorubicin and carboplatin) in a breast cancer xenograft model. Methods: Immunodeficient mice bearing MDA-MB-231 breast cancer cells were treated with AOA alone, doxorubicin or carboplatin alone, or AOA in combination with the chemotherapeutic agent for four weeks. The tumors were evaluated for histopathological and molecular alterations. Statistical analysis: Tumor growth was analyzed using a mixed-effects model for repeated measures data to account for dependence among observations within the same animal. Results: We observed a significant inhibition of tumor volume in mice treated with AOA in combination with doxorubicin or carboplatin compared to groups receiving single drugs (p&amp;lt;0.01). Western blot analysis of tumors treated with drug combinations showed decreased cyclin D1 level and increased p21 levels. Changes in key components of the glycolytic pathway are being examined. Conclusion: Our results suggest that targeting the metabolic pathway results in significant tumor inhibition in preclinical models of breast cancer and potentially could serve as attractive therapeutic targets for breast cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4088. doi:10.1158/1538-7445.AM2011-4088