tbuckley/cabot-search huggingface dataset:
Rétablissement de continuité après technique de Hartmann modifiée: action conjuguée de l’endoscopie et de la coelioscopie. A propos de cinq cas
Authors: N Pichon, F Lachachi, F Maisonnette, F Cessot, B Descottes, D Sautereau
Journal: Endoscopy (2004)

But: Elaborer une technique chirurgicale dans les péritonites par perforation diverticulaire sigmoïdienne permettant, dans un second temps opératoire, un rétablissement de continuité systématique et précoce par une technique associant la célioscopie et l’endoscopie. Patients et Méthodes: Entre décembre 2001 et mai 2002, 5 patients ont été admis en urgence pour péritonite sur perforation diverticulaire sigmoïdienne. Le premier temps opératoire consistait à réaliser une sigmoidectomie par laparotomie avec anastomose colorectale latéro terminale à muqueuse fermée protégée par une colostomie en fosse iliaque gauche. Le second temps opératoire, précoce chez les 5 patients, consistait à rétablir la continuité par l’action conjuguée de la célioscopie et de la coloscopie. Un contrôle endoscopique de l’anastomose était réalisé à 1 an. Résultats: Le rétablissement de continuité a été systématique chez les 5 patients sans recours à la laparotomie. Le délai entre l’intervention initiale et le rétablissement était de 55 ± 23 jours. La durée de l’intervention de rétablissement était de 65 ± 7 min. La durée d’hospitalisation après le rétablissement était de 6,5 ± 2 jours. Aucune complication post opératoire et aucun décès n’ont été observés. La coloscopie à un an ne décelait aucune sténose anastomotique. Conclusion: La technique chirurgicale que nous avons développée permet d’éviter les inconvénients de la technique de Hartmann classique (pourcentage élevé de colostomie définitive, délai de rétablissement de continuité supérieur à quatre mois, difficultés à disséquer le moignon rectal restant lors du rétablissement de continuité) mais également ceux de l’anastomose colorectale protégée (nécessité de conditions locales satisfaisantes, risque de fistule anastomotique ou de déhiscence post opératoire). Par ailleurs, cette technique a ses propres avantages: rétablissement de continuité précoce, protection de l’anastomose vis à vis de la contamination fécale par le maintien d’une interface muqueuse, durée d’hospitalisation plus courte lors du rétablissement de continuité, absence de sténose tardive de l’anastomose, contrôle endoscopique de la longueur du moignon colique.
P124 MATRIX METALLOPROTEINASE (MMP)-DEPENDENT SHEDDING REDUCES NK CELL FcgRIIIa EXPRESSION IN CHRONIC HCV INFECTION WITHOUT AFFECTING THE EFFICIENCY OF ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY
Authors: B. Oliviero, S. Mantovani, A. Zanaboni, M.U. Mondelli
Journal: Journal of Hepatology (2014)
The Clinical Outcome of Prospective Screening for Multiple Endocrine Neoplasia Type 2A
Authors: R F Gagel, A H Tashjian, T Cummings, N Papathanasopoulos, M M Kaplan, R A DeLellis, H J Wolfe, S Reichlin
Journal: New England Journal of Medicine (1988)

An important question facing physicians who care for families with multiple endocrine neoplasia type 2a is whether prospective screening to detect early abnormalities of the thyroid, parathyroid, or adrenal glands favorably influences the ultimate course of the disease. An 18-year study of a large family has allowed us to examine the effect of early treatment on the clinical course of the disease. Of 22 patients who underwent thyroidectomy for early C-cell abnormalities, 19 remained free of detectable medullary thyroid carcinoma according to all criteria, at a mean of 11 years after thyroidectomy. None of the 22 patients had evidence of parathyroid disease either at the time of surgery or after a mean follow-up of 10 years. Prospective screening for adrenal medullary abnormalities by means of measurement of 24-hour urinary epinephrine excretion and the ratio of urinary epinephrine to norepinephrine was predictive of pheochromocytoma in 10 of 11 patients (with a false negative result in one patient) but was not useful in diagnosing adrenal medullary hyperplasia. We conclude that regular, prospective screening and early treatment of the manifestations of multiple endocrine neoplasia can prevent metastasis of medullary thyroid carcinoma and the morbidity and mortality caused by pheochromocytoma.
Punishing Health Care Fraud — Is the GSK Settlement Sufficient?
Authors: Kevin Outterson
Journal: New England Journal of Medicine (2012)

Interview with Prof. Kevin Outterson on record-breaking settlements of pharmaceutical fraud cases and the need for further regulation. (14:05)Download The Department of Justice has announced the largest settlement ever in a health care fraud case: GlaxoSmithKline will plead guilty to three criminal counts and settle civil charges, paying $3 billion to the federal and state governments. But is that sufficient?
P1301 THE ITA.LI.CA CRITERIA TO SELECT PATIENTS WITH HEPATOCELLULAR CARCINOMA FOR LIVER TRANSPLANTATION: A NOVEL APPROACH BASED ON TRANSPLANT BENEFIT ANALYSIS
Authors: A. Vitale, F. Trevisani, F. Farinati, P. Burra, P. Angeli, E.G. Giannini, U. Cillo
Journal: Journal of Hepatology (2014)
Vasomotor control of capillary transit time heterogeneity in the canine coronary circulation.
Authors: C P Rose, C A Goresky
Journal: Circulation Research (1976)

A set of indicator-dilution studies of the coronary circulation of the intact functioning heart was carried out in the dog to provide a data base for defining the effect of changes in vasomotor control on the exchange of materials across the myocardial capillaries. The reference substance used was 125I-labeled albumin; the diffusible substance used was 14C-labeled sucrose. Model analyses of the data were carried out. In previous models of the capillary exchange in the coronary circulation, it had been assumed that a single capillary transit time is representative of the whole. The data acquired here indicate that there is a very large heterogeneity of capillary transit times in the intact heart, and that the single transit time model is approximately true only when the resistance vessels are maximally dilated. The present pattern of findings is explained best by a model of the coronary microcirculation based on capillary-large vessel units with a variable heterogeneity of flow or capillary lengths, hence of transit times. We conclude that a major determinant of the extraction of each diffusible substance, on a microscopic level, is the distribution of capillary transit times.
Arthritis Associated with Intestinal-Bypass Procedure for Morbid Obesity
Authors: J. R. Wands, J.T. La Mont, E. Mann, K.J. Isselbacher
Journal: New England Journal of Medicine (1976)

Five patients were studied after intestinal-bypass operations for morbid obesity to determine if the arthritis observed in three of these patients was associated with circulating cryoproteins. Only serum from the three patients with acute arthritis contained cryoprotein complexes. The complexes comprised IgG, IgM, IgA, complement components C3, C4, C5 and IgG antibody against Escherichia coli and Bacillus fragilis. The C3-activator fragment of the properdin complex was identified in fresh serum samples obtained from two of the three patients with circulating cryoprotein complexes and arthritis. These observations suggest that systemically absorbed intestinal bacterial antigens may lead to (or contribute to) the formation of circulating cryoprotein complexes. Circulating cryoprotein complexes activated both the classical and alternate complement pathways and may be important in the pathogenesis of the arthritis associated with the intestinal-bypass procedure for morbid obesity.
Histoplasmosis presenting as pancreatic head mass lesion and gastric outlet obstruction in an immunocompetent patient
Authors: Narendra Choudhary, Rajesh Puri, Maneesh Paliwal, Mridula Guleria, Randhir Sud
Journal: Endoscopy (2014)

A 61-year-old woman presented with vomiting and progressive weight loss. Blood counts, and liver and kidney function tests were normal. Upper gastrointestinal endoscopy showed a grossly dilated stomach with food residue, thickened duodenal folds, and luminal obstruction in the second part of the duodenum. Abdominal computed tomography showed features suggestive of gastric outlet obstruction and head/uncinate process mass lesion of the pancreas causing duodenal obstruction ([Fig. 1]). An endoscopic ultrasound (EUS) was done, and revealed a hypoechoic lesion in the head of the pancreas, with loss of planes between the pancreas and the duodenal walls ([Fig. 2]). EUS-guided fine-needle aspiration (FNA) was performed, and subsequent periodic acid-Schiff staining showed thin-walled, round yeast forms with histoplasma morphology, suggestive of pancreatic histoplasmosis ([Fig. 3]). Test for human immunodeficiency virus was negative.
Sentinel Node Biopsy After Neoadjuvant Chemotherapy for Node-Positive Breast Cancer: Does Axillary Ultrasound Improve Performance?
Authors: Starr Koslow Mautner, Hiram S. Cody
Journal: Journal of Clinical Oncology (2015)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2014.60.3316 Journal of Clinical Oncology - published online before print September 14, 2015 PMID: 26371144 Sentinel Node Biopsy After Neoadjuvant Chemotherapy for Node-Positive Breast Cancer: Does Axillary Ultrasound Improve Performance? Starr Koslow MautnerxStarr Koslow MautnerSearch for articles by this author , Hiram S. Cody IIIxHiram S. Cody IIISearch for articles by this author Show More Memorial Sloan Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.2014.60.3316 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
SP0123 The Cartilage Injury Response and Its Relevance to Osteoarthritis
Authors: T. Vincent
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> It was some years ago that we chanced upon the observation that the best way to activate a chondrocyte in its matrix was to subject it to cutting injury. Since this time we and others have identified many signaling pathways that are activated in response to cutting including the ERK, p38, JNK, NFkB, Wnt, PI3K and Src pathways (and most likely others)! The upstream initiators of this injury response include release of growth factors from the pericellular matrix, stimulation of the cell through ion channels e.g. TRPV4 and activation of the primary cilium. Down stream these pathways regulate a number of genes some of which likely promote catabolic activities within the tissue, some of which stimulate neuronal sensitisation and others, which, we speculate, stimulate the tissue to repair. These responses appear to be recapitulated by in vivo injury when the cartilage is subjected to abnormal mechanical load after surgical joint destabilization. Thus pathways that have been explored by crude in vitro models appear to be relevant to in vivo injury response in early disease. The next challenge will be understanding how different joint activities promote activation of specific mechanosensitive pathways to selectively modulate outcome. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6242
209 SYSTEMATIC CT-SCAN ON POST-OPERATIVE DAY 7 AFTER LIVER TRANSPLANTATION DECREASES THE RATE OF RETRANSPLANTATION FOR ARTERIAL COMPLICATIONS
Authors: R. Memeo, E. Vibert, O. Ciacio, R. Adam, J.-C. Duclos- Vallee, D. Samuel, D. Castaing
Journal: Journal of Hepatology (2012)
P2-02-09: TP53 Mutation Patterns in Breast Cancer Subgroups.
Authors: A Dumay, J-P Feugeas, E Wittmer, J Lehmann-Che, P Bertheau, M Espié, Cremoux P de, F André, C Sotiriou, L Pusztai, Thé H de
Journal: Cancer Research (2011)

Abstract Tumor protein 53 (TP53) is the most commonly altered gene in human cancers. In breast cancers, TP53 is mutated in approximately 30% of all cases, but this frequency fluctuates widely within the different molecular subclasses. Different types of mutations may be observed, such as substitutions (replacement of a nucleotide pair by another one), or complex mutations (deletions or insertions of one or more nucleotides). Mutation types may reflect mechanism of DNA lesion or DNA repair deficiencies. Furthermore, mutations can give rise to different effects such as truncating mutations leading to loss of function, or missense mutations often leading to dominant negative activity. Those mutation effects can be advantageous in tumorigenesis and thus can be subject to selective pressure. Here we classified 572 breast tumors in three groups, according to microarray data: luminal, basal and molecular apocrine. TP53 status was assessed by a yeast-based functional assay (FASAY) and cDNA sequencing. We then assessed whether any feature of TP53 mutations would be preferentially associated to a specific subtype of breast cancer. - In term of TP53 mutation frequencies, as expected, lowest frequency was observed in luminal subgroup (26%) and highest in basal (90%) and molecular apocrine (70%). Notably, much higher rate of TP53 mutations occurred in luminal B subgroup (41%) than in luminal A one (17%), suggesting that TP53 may be an important feature in progression from luminal A to B. - In term of mutations types, luminal tumors showed high frequency of substitutions, while molecular apocrine and basal presented increased rate of deletions and insertions, reflecting probably increased rate of DNA breaks. This suggests that same mutational events may occur in basal and molecular apocrine tumors. - In term of mutation effects, we found high frequency of missense mutations in luminal tumors (notably AT to GC) and much higher rate of truncating mutations in basal tumors. These observations point to an existence of different selection pressure in each of them, such as a strong pressure for P53 mutations with potential dominant negative inhibition of P73/P63 (recently shown to favor invasion), in luminal tumors. Collectively, these results point not only to different mechanisms of P53 gene inactivation, but also different functional consequences among the different breast cancer subclasses. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-02-09.
Nobel Prize for Medicine Awarded to Elion, Hitchings, Black
Authors: K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1988)

Nobel Prize for Medicine Awarded to Elion, Hitchings, Black Get access Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 18, 16 November 1988, Pages 1437–1438, https://doi.org/10.1093/jnci/80.18.1437 Published: 16 November 1988
Racial Differences in the Relation between Blood Pressure and Insulin Resistance
Authors: Mohammed F. Saad, Stephen Lillioja, Bulangu L. Nyomba, Charles Castillo, Robert Ferraro, Michele De Gregorio, Eric Ravussin, William C. Knowler, Peter H. Bennett, Barbara V. Howard, Clifton Bogardus
Journal: New England Journal of Medicine (1991)

Insulin resistance and the concomitant compensatory hyperinsulinemia have been implicated in the pathogenesis of hypertension. However, reports on the relation between insulin and blood pressure are inconsistent. This study was designed to investigate the possibility of racial differences in this relation.
S139 Cough responses to tussive agents in health and disease
Authors: S. Khalid, R. Dockry, K. Holt, H. Sumner, D. Valdramidou, M. A. Birrell, M. G. Belvisi, A. Woodcock, J. A. Smith
Journal: Thorax (2011)

<h3>Introduction</h3> Capsaicin or citric acid cough challenges have been used as an objective measure of cough reflex sensitivity for many decades. It remains unclear how the response to these agents differs in different diseases and how the response to one cough challenge agent differs from that to another. Prostaglandin E2 is known to result in cough when given as an inhalational agent, but has not been used as inhalational cough challenge agent. <h3>Objectives</h3> To assess the ability of individual challenges and combined challenge responses to discriminate between diagnostic groups and healthy volunteers. <h3>Methods</h3> We studied 102 subjects, median age 60.0 years (IQR 51.0–65.0) and 50% female (healthy volunteers n=21, healthy smokers n= 20, COPD n=18, asthma n=22 and chronic cough n=21). A doubling-dose, single inhalation method was used to measure the concentration of capsaicin (CAP), citric acid (CA) and prostaglandin E2 (PGE2) evoking at least 5 coughs (C5) within 15 s of administration, performed at weekly intervals. The operator was blinded to the challenge agent and each challenge contained 3 randomly interspersed placebo inhalations (saline). Data was analysed by multinomial logistic regression with healthy volunteers used as the reference category. <h3>Results</h3> Smokers (p=0.03) and COPD patients (p=0.003) had a significantly higher PGE2 logC5 than healthy volunteers. CA logC5 however was significantly lower in asthma (p=0.013), and chronic cough (p=0.001) compared with healthy volunteers. CAP logC5 was also significantly lower in chronic cough (p&lt;0.001) but also in COPD (p=0.035) compared with healthy volunteers. Combining responses to all challenge agents suggested each individual challenge independently predicted the differences between disease groups and healthy volunteers (PGE2 p&lt;0.001, CA p=0.018 and CAP p=0.015). <h3>Conclusions</h3> Cough responses to inhalational cough challenges can discriminate healthy controls from airway diseases. Furthermore, cough challenge agents differ in their ability to distinguish health from disease implying different underlying mechanisms drive coughing in these diagnoses. A combination of cough challenge tests appears to be better at discriminating diagnostic groups compared with any individual test in isolation.
Abstract 88: Targeting Bcl-XL enhances arsenic-induced cell death in ovarian cancer cells
Authors: Ibrahim Tekedereli, Gabriel Lopez-Berestein, Bulent Ozpolat
Journal: Cancer Research (2010)

Abstract Autophagy is an evolutionary conserved process in which long-lived proteins and damaged organelles are digested under physiological conditions including starvation. Autophagy has also been shown to act as a programmed cell death mechanism (type II PCD) and considered as caspase independent cell death. Several studies showed that autophagy has been triggered by anti-cancer treatments, such as chemo and hormonal therapy and radiotherapy and growth factor deprivation, function either as a protective survival pathway or cellular death mechanism. Arsenic trioxide (ATO), which is a FDA approved drug and used as a treatment in acute promyelocytic leukemia, has been reported to induce autophagic and/or apoptotic cell death in leukemia, glioblastoma and also ovarian cancer cells, we have previously found that ATO induces autophagy in ovarian cancer cells. Here, we investigated the role of antiapoptotic protein Bcl-Xl, which inhibits autophagy by binding beclin-1, an essential autophagy promoting protein, in arsenic induced apoptosis and determined the effects of ATO/Bcl-XL RNA interference combination therapy in ovarian cancer. We found that ATO induces dose dependant growth inhibition in MTS proliferation assay. ATO treatment (2-4 uM) induced apoptosis in A2780 (40-50 %) and SKOV3 (20-25 %) cells, detected by annexin V staining and flow cytometric (FACS) analysis and by caspase 9 and PARP cleavage (Western blotting). ATO induced marked autophagy in A2780 (60-70 %) and in SKOV3 (15-20 %) as indicated by LC3-II, a marker for autophagy, formation autophagic vacuoles detected by acridine orange staining and FACS and by transmission electron microscopy. ATO induced Bcl-XL protein expression in ovarian cancer cells. We also found expression of high levels of Bcl-XL in all ovarian cancer cell lines including drug (i.e., cisplatin and paclitaxel) resistant cells. Inhibition of Bcl-XL expression by Bcl-XL siRNA induced growth inhibition (40-60 %), apoptosis (40-60 %) and autophagy (50-60% in A2780 and 15-25 % in SKOV3 ovarian cancer cell line). Furthermore, combination of ATO with Bcl-XL siRNA led to 90 % cell death and 70 % apoptosis in both A2780 and SKOV3 cells. Overall, our results suggest that combination of ATO and Bcl-XL induced predominantly apoptosis, although each of them induced autophagy. In conclusion we provided first evidence that inhibition of Bcl-XL induces autophagy in ovarian cancer cells and sensitizes them to ATO that may be a promising treatment regimen for ovarian cancer patients. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 88.
SAT0288 Male Gender is Associated with Accelerated Radiographic Progression in Axial Damage but not with Progression of Peripheral Damage
Authors: L. Eder, A. Thavaneswaran, V. Chandran, R. Cook, D. D. Gladman
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Gender-related differences have not been thoroughly explored in Psoriatic Arthritis (PsA). Our group recently reported that men suffered from more severe radiographic damage in their peripheral and axial joints in a cross-sectional analysis. <h3>Objectives</h3> We aimed to further investigate whether male gender is associated with increased radiographic progression of joint damage compared to females. <h3>Methods</h3> A retrospective cohort analysis was performed among patients who have been followed in a large PsA clinic from 1978 to 2012. Patients were followed according to a standard protocol at 6-12 month intervals. Radiographs of the hands, feet and spine were performed at 2 year intervals. Radiographic damage based on 42 joints in the hands and feet was assessed according to a modification of the Steinbrocker method. Radiographic damage to the lumbar and cervical spine was scored using the modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS). For each patient all available radiographic data were included. Patients who initiated treatment with anti TNFα agents were censored. The outcome of interest was the difference in the modified Steinbrocker score and mSASSS compared to the previous assessment. Multivariate regression analysis using Generalized Estimating Equations (GEE) for repeated measures was used to compare progression in radiographic damage across the genders incorporating available information from all time points. <h3>Results</h3> 1067 PsA patients were included in the study (females: 43.5%, males: 56.5%). Females had higher duration of psoriasis (16.8±13.3 vs. 14.1±11.5 years, p&lt;0.001) and PsA (7.6±9.3 vs. 6.2±7.3years, p=0.007). At first visit, mSASSS was higher in males (2.4±7.7 vs. 0.03±0.24, p=0.002) however no difference was found in the mean modified Steinbrocker scores across the genders (p=0.24). Gender was not associated with progression in radiographic damage in the peripheral joints in both univariate and multivariate analyses. In a multivariate regression analysis tender joint count (p=0.007) and modified Steinbrocker score at first visit (p=0.0002) predicted progression in modified Steinbrocker score. In contrast, male gender predicted progression in mSASSS (β=0.25, p=0.04) in multivariate analysis, while the use of Non-Steroidal Anti Inflammatory Drugs (NSAIDs) was found to have a protective effect (p&lt;0.0001). <h3>Conclusions</h3> Among patients with PsA, men tend to accumulate more radiographic axial damage compared to women. No effect of gender on progression in radiographic joint damage was observed. It is unclear whether these findings are secondary to differences in occupational physical activity, hormonal changes or other factors. <h3>Disclosure of Interest</h3> None Declared