tbuckley/cabot-search huggingface dataset:
AB0932 Infectious Spondylodiscitis – a Case Series Analysis
Authors: A. Aouadi, D. Kaffel, I. Cherif, W. Hamdi, I. Zouch, M.M. Kchir
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Spondylodiscitis is a quite rare disease characterized by insidious onset and non-specific symptoms such as back pain and fever. Consequently, early diagnosis is difficult and is often missed despite repeated warnings in the medical journals and better access to imaging techniques such as magnetic resonance imaging (MRI). Spondylodiscitis may take acute, subacute or chronic course. <h3>Objectives</h3> We aimed to describe the clinical and laboratory features as well as diagnostic difficulties in the case series of spondylodiscitis. <h3>Methods</h3> Retrospective study including patients diagnosed as spondylodiscitis and hospitalized in our department between 2006 and 2014. <h3>Results</h3> Sixteen patients were included. Ten patients (62,5%) were male. The mean age of our patients was 57 years [20 – 83]. Predisposing factors were found in 7 patients (43%): diabetes in 5 cases, chronic renal failure in 1 case and a patient with sickle cell disease. The lumbar spine was most affected (75%), the dorsal spine was affected in (12,5%) as the cervical spine (12,5%). A-multi stage spondylodiscitis was found in 3 cases. A neurological deficit was noted in 2 patients. Inflammation tests were disturbed in 87,5% of them. Radiographs of the spine were abnormal in all cases. Fourteen patients had MRI exam, showed epiduritis in 6 patients and paravertebral abscess in 7 patients. The causative microorganism was identified in 14 cases (87,5%): brucella in 6 patients, mycobacterium tuberculosis in 5 patients, staphylococcus in 1 case, Gram-negative germs in 1 case and streptococcus in 1 case. Multi-bacterial spondylodiscitis was found in 1 patient. All of them received initially adapted antibiotics. Two patients have not been followed, and most of the rest showed good response (78%). Neurological complication occurred in 1 case and sepsis occurred in 1 other case. Disturbance of liver function due to treatment occurred in two cases with good subsequent evolution. <h3>Conclusions</h3> Spondylodiscitis is an emergency which must be diagnosed on time to avoid life threatening complications, neurological sequelae and spinal deformities. <h3>Disclosure of Interest</h3> None declared
A universal system to select gene-modified hepatocytes in vivo
Authors: Sean Nygaard, Adi Barzel, Annelise Haft, Angela Major, Milton Finegold, Mark A. Kay, Markus Grompe
Journal: Science Translational Medicine (2016)

Many genetic and acquired liver disorders are amenable to gene and/or cell therapy. However, the efficiencies of cell engraftment and stable genetic modification are low and often subtherapeutic. In particular, targeted gene modifications from homologous recombination are rare events. These obstacles could be overcome if hepatocytes that have undergone genetic modification were to be selectively amplified or expanded. We describe a universally applicable system for in vivo selection and expansion of gene-modified hepatocytes in any genetic background. In this system, the therapeutic transgene is coexpressed with a short hairpin RNA (shRNA) that confers modified hepatocytes with resistance to drug-induced toxicity. An shRNA against the tyrosine catabolic enzyme 4-OH-phenylpyruvate dioxygenase protected hepatocytes from 4-[(2-carboxyethyl)-hydroxyphosphinyl]-3-oxobutyrate, a small-molecule inhibitor of fumarylacetoacetate hydrolase. To select for specific gene targeting events, the protective shRNA was embedded in a microRNA and inserted into a recombinant adeno-associated viral vector designed to integrate site-specifically into the highly active albumin locus. After selection of the gene-targeted cells, transgene expression increased 10- to 1000-fold, reaching supraphysiological levels of human factor 9 protein (50,000 ng/ml) in mice. This drug resistance system can be used to achieve therapeutically relevant transgene levels in hepatocytes in any setting.
Meta-analysis of risk factors for Parkinson’s disease dementia
Authors: Yaqian Xu, Jing Yang, Huifang Shang
Journal: Translational Neurodegeneration (2016)

Parkinson's disease (PD) is a common heterogeneous neurodegenerative disorder in elder population. Parkinson's disease dementia (PDD) is one of the most common non-motor manifestations in PD patients. No comprehensive review has been conducted to assess risk factors for PDD.A systemic search for studies on PDD risk factors was performed. Cohort and case-control studies that clearly defined PDD and presented relevant data were included. The data were analyzed to generate a pooled effect size and 95 % confidence interval (CI). Publication bias was assessed using the Egger's test and the Begg's test.A systematic search was conducted and yielded 5195 articles. After screening, 25 studies were included in the current analysis. Development of PDD was positively associated with age (odds ratio [OR] 1.07, 95 % CI 1.03-1.13), male (OR 1.33, 95 % CI 1.08-1.64), higher Unified Parkinson's Disease Rating Scale (UPDRS) part III scores (relative risk [RR] 1.04, 95 % CI 1.01-1.07), hallucination (OR 2.47, 95 % CI 1.36-4.47), REM sleep behavior disorder (RBD) (OR 8.38, 95 % CI 3.87-18.08), smoking (ever vs. never) (RR 1.93, 95 % CI 1.15-3.26) and hypertension (OR 1.57, 95 % CI 1.11-2.22). An inverse association was found between education (RR 0.94, 95 % CI 0.91-0.98) and PDD. Other reported factors, including age of onset, disease duration of PD, Hoehn and Yahr stage and diabetes mellitus were not significantly associated with PDD.Advanced age, male, higher UPDRS III scores, hallucination, RBD, smoking and hypertension increase the risk of PDD, whereas higher education is a protective factor for PDD.
PWE-389 Anal acoustic reflectometry is a test of the internal anal sphincter?
Authors: J Nicholson, J Pearson, K Telford, E Kiff, W DeMello
Journal: Gut (2015)

<h3>Introduction</h3> Conventional anal manometry (ARM) suggested that the internal anal sphincter (IAS) contributes 60–85% of anal resting pressure, the remaining 15–40% being attributable to the tonic contraction of the external anal sphincter (EAS) and anal cushions. Anal acoustic reflectometry (AAR) is a more specific and sensitive indicator of sphincter function than ARM. Our aim was to determine the relative contributions of the IAS and EAS to anal resting pressure by isolating the IAS for interrogation using a bilateral pudendal nerve block (bPNB). <h3>Method</h3> Prospective cohort study of patients with pudendal neuralgia undergoing bPNB. Blocks were trans-vaginal (Women) and trans-gluteal (Men). EAS electromyography (EMG) was performed before and 5 mins after bPNB to establish its success. Patients received AAR and manometry (maximum resting pressure MRP, maximum squeeze pressure MSP and incremental squeeze pressure ISP) before and 30 mins after bPNB. Variables were compared using a paired t-test for parametric data and Wilcoxon signed rank test or Mann-Whitney U test* for non-parametric data. <h3>Results</h3> 15 patients, 10 (67%) women, median age 59 (25–89) and median reduction in EMG motor unit potential activity of 45% (Range -25–48%). There was no difference in reduction of EMG activity between trans-vaginal and trans-gluteal bPNB approach (30.3 v 38.5% p = 0.762*). There was no significant change in any AAR parameter at rest. AAR squeeze opening pressure showed a significant reduction post bPNB (121 v 104 cmH<sub>2</sub>O p = 0.039). MSP and ISP showed a significant reduction post bPNB; MRP 75 v 71 cmH<sub>2</sub>O p = 0.5, MSP 154 v 118 cmH<sub>2</sub>O p = 0.02, ISP 79 v 47 cmH<sub>2</sub>O p = 0.02. <h3>Conclusion</h3> We found a significant reduction in all measurements of EAS function after bPNB. No change was found after a 45% median reduction in EAS activity in measurements of IAS function, suggesting that AAR is primarily an investigation of the IAS. <h3>Disclosure of interest</h3> None Declared.
Public health response to two incidents of confirmed MERS-CoV cases travelling on flights through London Heathrow Airport in 2014 – lessons learnt
Authors: F Parry-Ford, N Boddington, R Pebody, N Phin, Collective on behalf of the Incident Management Team
Journal: Eurosurveillance (2015)

In May 2014, Public Health England was alerted to two separate laboratory-confirmed cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection who transited through London Heathrow Airport while symptomatic on flights from Saudi Arabia to the United States of America. We present the rationale for the public health response to both incidents, and report results of contact tracing. Following a risk assessment, passengers seated two seats around the cases were prioritised for contact tracing and a proactive media approach was used to alert all passengers on the planes of their possible exposure in both incidents. In total, 64 United Kingdom (UK) residents were successfully contacted, 14 of whom were sat in the priority area two seats all around the case(s). Five passengers reported respiratory symptoms within 14 days of the flight, but all tested were negative for MERS-CoV. Details of non-UK residents were passed on to relevant World Health Organization International Health Regulation focal points for follow-up, and no further cases were reported back. Different approaches were used to manage contact tracing for each flight due to variations in the quality and timeliness of the passenger contact information provided by the airlines involved. No evidence of symptomatic onward transmission was found.
Increased norovirus activity in Scotland in 2012 is associated with the emergence of a new norovirus GII.4 variant
Authors: S Bennett, A MacLean, R S Miller, C Aitken, R N Gunson
Journal: Eurosurveillance (2013)

Preview this article: Increased norovirus activity in Scotland in 2012 is associated with the emergence of a new norovirus GII.4 variant, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/18/2/art20349-en-1.gif
SAT0019 SDF-1/CXCR4 Is associated with the Disease Activity and Bone and Joint Destruction in Patients with Rheumatoid Arthritis Treated with Golimumab
Authors: K. Kanbe, J. Chiba, Y. Inoue, M. Taguchi, A. Yabuki
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> We previously reported that a chemokine stromal cell-derived factor 1 (SDF-1) increased in joint fluid of rheumatoid arthritis (RA) without biologics compared with osteoarthritis [1]. However there is no investigation whether SDF-1 and its receptor CXCR4 axis associate to disease activity and bone and joint destruction. <h3>Objectives</h3> This study aimed to analyze whether SDF-1 and CXCR4 related to the clinical outcome and bone and joint destruction in RA treated with golimumab. On aspect of assessment of large joint destruction, compared with the Larsen grade, we used the Assessment of Rheumatoid Arthritis by Scoring of Large-Joint Destruction and Healing in Radiographic Imaging (ARASHI) score has a high intraclass correlation coefficient (ICC) when assessing large joint destruction [2]. <h3>Methods</h3> Synovial tissues were obtained from 15 golimumab-treated patients and assessed for SDF-1 and CXCR4 with a new immunohistological scoring system (IH score) [3]. The IH score was applied for the analysis of correlation between synovial SDF-1 or CXCR4 and DAS28 (CRP), Rooney score, synovial tumor necrosis factor alpha (TNF-α) or interleukin-6 (IL-6), CD4, CD20, CD68, vascular endothelial growth factor (VEGF) and ARASHI score. Receiver-operating characteristic (ROC) analysis was performed to predict ARASHI score by using IH scores of CXCR4. <h3>Results</h3> The IH score of SDF-1 strongly correlated with the disease activity score DAS28 (CRP) and serum IL-6. The IH score of CXCR4 significantly correlated with the synovial CD4 and ARASHI score. IH score of VEGF was significantly correlated serum IL-6. ROC analysis of CXCR4 and ARASHI score (&gt;10 points) revealed cutoff of IH score at 12 points (sensitivity 0.875, specificity 0.429, Odds 5.25) for predicting joint destruction during treatment. <h3>Conclusions</h3> This study indicates that the synovial SDF-1 correlated with the disease activity and its receptor CXCR4 related to joint destruction in patients with rheumatoid arthritis treated with golimumab. <h3>References</h3> Kanbe K, Takagishi K, Chen Q. Arthritis Rheum 2002;46:130-7. Kaneko A, Matsushita I, Kanbe K, et al. Mod Rheumatol 2013;23:1053-62. Kanbe K, Hara R, Chiba J, et al. Mod Rheumatol 2013;23:1053-62. <h3>Acknowledgements</h3> This work was supported in part by Grant-in-Aid for Scientific Research (KAKENHI) (C) (24592284) from the Ministry of Education, Culture, Sports, Science and Technology and the Japan Society for the Promotion of Science. <h3>Disclosure of Interest</h3> None declared
FRI0388 Monitoring Local Therapy in Sjögren's Syndrome with Virtual Touch Tissue Quantification Sonography
Authors: B. Hofauer, M. Bas, C. Heiser, J. Schukraft, N. Mansour, A. Knopf
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Evaluation of various sonographic techniques in diagnosis and follow-up of salivary gland involvement in Sjögren9s Syndrome is part of on-going investigations. Virtual Touch Tissue Quantification (VTTQ) sonography, as modern sonographic method, enables the objective measurement of parotid and submandibular gland stiffness in SS, as recent reports could demonstrate. Consequently the consideration emerges, if VTTQ is suitable to monitor the response to local or systemic treatment. <h3>Objectives</h3> Is Virtual Touch Tissue Quantification sonography suitable to monitor the response to a liposomal local therapy in Sjögren9s Syndrome? <h3>Methods</h3> 50 patients with pSS, diagnosed according to the AECG criteria, were included (group 1). As comparison group 50 patients were chosen with condition following radiotherapy of the head and neck region (including the salivary glands, group 2). Clinical data were collected and sonographic examination including VTTQ was performed. Subjective symptoms were evaluated via visual analogue scales (VAS). After a two-months period of liposomal local therapy sonographic examination including VTTQ was repeated and subjective symptoms were re-evaluated. In group 1, right side parotid and submandibular glands were examined; in group 2, the – in regard to the irradiated side – ipsi- and contralateral parotid and submandibular glands were examined. <h3>Results</h3> Before local treatment, the mean VTTQ value of parotid glands in group 1 was 2.99m/s<sup>2</sup> (SD 0.93); in group 2, the mean VTTQ value of the ipsilateral parotid glands was 2.35m/s<sup>2</sup> (SD 0.7) and of the contralateral parotid glands was 2.14m/s<sup>2</sup> (SD 0.55). Mean VTTQ value of the submandibular glands in group 1 was 2.15m/s<sup>2</sup> (SD 0.57); in group 2, the mean VTTQ value of the ipsilateral submandibular glands was 2.27m/s<sup>2</sup> (SD 0.69) and of the contralateral submandibular glands was 2.17m/s<sup>2</sup> (SD 0.57). After two-months treatment with locally applied liposomes a significant decline of VTTQ values could be observed both in parotid glands in group 1 (2.33m/s<sup>2</sup>, SD 0.70, p&lt;0.001) and in ipsilateral (2.20m/s<sup>2</sup>, SD 0.56, p=0.01) and contralateral (2.07m/s<sup>2</sup>, SD 0.50, p=0.047) parotid glands in group 2. Submandibular glands did not show any significant change in both groups. A significant reduction of the subjective sensation of xerostomia could be observed (p=0.0001). <h3>Conclusions</h3> With the application of Virtual Touch Tissue Quantification sonography a decline in parotid gland stiffness could be observed both in Sjögren9s Syndrome and condition following radio therapy accompanied by a significant improvement of the subjective sensation of xerostomia. The seromucous submandibular glands did not show any changes compared to the serous parotid glands. <h3>Disclosure of Interest</h3> None declared
Is loxapine more effective than chlorpromazine in paranoid schizophrenia?
Authors: A Rifkin, E Rieder, S Sarantakos, K Saraf, J Kane
Journal: American Journal of Psychiatry (1984)

The authors compared loxapine with chlorpromazine in inpatients with paranoid schizophrenia and found no difference in clinical efficacy. Thus a previous finding, based on retrospective analyses, that loxapine was superior to other neuroleptics in the treatment of paranoid schizophrenia was not verified in this prospective study.
Utility of non-invasive instantaneous screening test for drug-induced cardiac damage.
Authors: W J Hrushesky
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.10.1438 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4045533 Utility of non-invasive instantaneous screening test for drug-induced cardiac damage. W J HrusheskyxW J HrusheskySearch for articles by this author https://doi.org/10.1200/JCO.1985.3.10.1438 PDF "Utility of non-invasive instantaneous screening test for drug-induced cardiac damage.." Journal of Clinical Oncology, 3(10), pp. 1438–1439© 1985 by American Society of Clinical Oncology
Incident risk factors as predictors of HIV seroconversion in the Lisbon cohort of men who have sex with men: first results, 2011–2014
Authors: P Meireles, R Lucas, C Carvalho, R Fuertes, J Brito, M J Campos, L Mendão, H Barros
Journal: Eurosurveillance (2015)

HIV incidence in men who have sex with men (MSM) is increasing in western countries, including Portugal. We aimed to estimate HIV incidence and to assess how individual short-term changes in exposures over time predict seroconversion. We evaluated participants of an open cohort of HIV-negative MSM enrolled after testing at a community-based voluntary HIV counselling and testing centre in Lisbon. At each evaluation a structured questionnaire was completed and HIV status was ascertained using rapid followed by confirmatory testing. Between April 2011 and February 2014, 804 MSM were followed for a total of 893 person-years. Predictors of HIV seroconversion were identified using Poisson generalised linear regression. The overall seroincidence was 2.80/100 person-years (95% confidence interval: 1.89-4.14). Men who seroconverted had a higher mean number of tests per year. Seroconversions were significantly associated with partner disclosure of HIV status during follow-up, newly-adopted unprotected anal intercourse (UAI) with a steady partner and being newly-diagnosed with syphilis during follow-up. Likewise, sexual intercourse with HIV-positive men, having an HIV-positive steady partner at least once during follow-up and persistent UAI with occasional partners were predictors of seroconversion. High HIV incidence in this cohort is likely driven by short-term contextual and behavioural changes during follow-up.
“Atypical” Cells in the Blood of Cancer Patients—Differentiation From Tumor Cells&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Avery A. Sandberg, George E. Moore, Jean R. Schubarg
Journal: JNCI Journal of the National Cancer Institute (1959)

“Atypical” and immature cells are frequent in the blood of patients with cancer. This conclusion is based on the examination of the blood from 525 subjects with cancer and from 132 subjects without cancer. Many cells are difficult to differentiate from tumor cells. Representative cells are illustrated, and their distribution and some of their morphological features are discussed.
U.K. guidelines for the management of Stevens–Johnson syndrome/toxic epidermal necrolysis in adults 2016
Authors: D. Creamer, S.A. Walsh, P. Dziewulski, L.S. Exton, H.Y. Lee, J.K.G. Dart, J. Setterfield, C.B. Bunker, M.R. Ardern‐Jones, K.M.T. Watson, G.A.E. Wong, M. Philippidou, A. Vercueil, R.V. Martin, G. Williams, M. Shah, D. Brown, P. Williams, M.F. Mohd Mustapa, C.H. Smith, P.M. McHenry, J.R. Hughes, M. Griffiths, K. Gibbon, A.J. McDonagh, D.A. Buckley, I. Nasr, V.J. Swale, C.E. Duarte Williamson, N.J. Levell, T. Leslie, E. Mallon, S. Wakelin, S. Ungureanu, P. Hunasehally, M. Cork, K. Towers, J. Donnelly, C. Saunders, A.G. Brain
Journal: British Journal of Dermatology (2016)
The Influence of Cortisone Acetate upon the Growth of a Transplanted Rhabdomyosarcoma in C3H Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: George M. Higgins, Ph. D., Warren A. Bennett, M. D.
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article The Influence of Cortisone Acetate upon the Growth of a Transplanted Rhabdomyosarcoma in C3H Mice Get access George M. Higgins, Ph. D., George M. Higgins, Ph. D. Division of Experimental Medicine, Mayo Foundation, University of Minnesota Search for other works by this author on: Oxford Academic PubMed Google Scholar Warren A. Bennett, M. D. Warren A. Bennett, M. D. Section of Pathologic Anatomy, Mayo Clinic, Rochester, Minn. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 4, February 1952, Pages 851–859, https://doi.org/10.1093/jnci/12.4.851 Published: 01 February 1952 Article history Received: 12 October 1951 Published: 01 February 1952
Protective Conditioning for Acute Graft-versus-Host Disease
Authors: Ernesto Ayala, Mohamed Kharfan-Dabaja
Journal: New England Journal of Medicine (2005)

n engl j med 353;25 www.nejm.org december 22, 2005 2718 tion during Instability in Coronary Artery Disease [FRISC] II4 and TACTICS5). It seems more plausible that the late (five-year) clinical benefit observed in the RITA-3 trial might have been a consequence of the more systemic effects of robust medical therapy given to high-risk patients in the routineinvasive-strategy group, which in turn lessened the likelihood of a new plaque rupture in one or more of the native coronary arteries that did not initially have a flow-limiting stenosis. Thus, cautious interpretation might be well advised for both the ICTUS and RITA-3 trials. William E. Boden, M.D. Hartford Hospital Hartford, CT 06102