AB0598 Thyroiditis in Systemic Lupus Erythematosus: A Case-Control Study
Authors: N. Khaldoun, A. Abdessemed, F. Bougrina, R. Chetouane, S. Haid, F. Rahal, T. Mellas, I. Megateli, S. Azeli, S. Lefkir, N. Brahimi, A. LadjouzeRezig, S. Louahchi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To determine the prevalence of thyroid antibodies (TA): antibodies against thyroid peroxidase (A-TPO) and thyroglobulin (A-TG) in Algerian patients with Systemic Lupus Erythematosus (SLE) and in a healthy population matched for age and sex and To search a dependency between the presence of TA and thyroid dysfunction. <h3>Methods</h3> Transversal study carried in BenAknoun hospital between January 2012 and May 2014 on 54 patients with SLE matched for age and sex to a control group of 88 healthy persons. For all patients collect of demographic data, duration of the disease and submitting to clinical examination. Thyroid hormones, TSH and autoantibodies against TPO, TG, DNA, Sm, SS-A, SS-B were measured. <i>Data analysis:</i> SPSS Software. Significant value for p≤0,05. Using chi2 test to compare %. <h3>Results</h3> 54 patients with SLE were included in this study (51 women, 3 males). Their average age was 40±11.7 years, mean disease duration was 10±7 years. The majority of patients (63%) had moderate activity against 37% with high activity. A-TPO were found respectively in 22.22% and 14.77% of lupus and controls (p=0.258), A-TG were found in 23.1% and 11.36% (p=0,066). We found a moderate but not significant link between the absence of A-TPO and the presence of anti Sm (p=0.06) and a significant link between the presence of A-TG and the presence of anti SSB (p=0.049). Subclinical hypothyroidism was found respectively in 9.25% and 2.27% of cases (p=0.062) and sub-clinical hyperthyroidism in 7.4% and 5.68% of cases (p=0.682). <h3>Conclusions</h3> In this preliminary study, there was no association between the occurrence of SLE and the presence of TA or subclinical and clinical thyroid dysfunction. But we found a statistical significance association between the presence of A-TG and the presence of antibodies against SS-B. <h3>References</h3> Autoimmune thyroid disease in systemic lupus erythematosus and sjögren9s syndrome. Scofield RH. Clinical Experimental rheumatology. 1996 May-Jun; 14(3):321-30. Thyroid Autoimmune diseases in patients with systemic lupus erythematosus. DPPO Viggiano, AOS Montandon, VS Barbosa, NA Silva. EULAR 2008-Paris 11-14 juin 2008. Association of systemic and thyroid autoimmune diseases. E Biro, Z Szekanecz, L Czirjak, K Danko, E Kiss, NA Szabo, G Zeher, E Bodolay, G Szegedi, G Bako. Clin Rheumatol.2006 Mar;25(2):240-5. Clinical manifestations and outcome of polyarthralgia associated with chronic lymphocytic thyroiditis. Punzi L, Sfriso P, Pianon M, Schiavon F, Ramonda R, Cozzi F, Todesco S. Semin Arthritis Rheum. 2002 Aug; 32(1):51-5. Autoimmune thyroid disease in systemic lupus erythematosus. Pyne D, Isenberg DA Ann Rheum Dis 2002;61:70–2. Thyroid disease in systemic lupus erythematosus and rheumatoid arthritis. Chan ATY, Al-Saffar Z, Bucknall RC. Rheumatology 2001;40:353–4. <h3>Disclosure of Interest</h3> None declared