tbuckley/cabot-search huggingface dataset:
Gastroenteritis outbreaks in elderly homes in the east of France during winter 2009/10: aetiology research for a series of 37 outbreaks
Authors: F Thouillot, C Delhostal, C Edel, A Bettinger, P Pothier, K Ambert-Balay, C Meffre, S Alsibai
Journal: Eurosurveillance (2012)

Although acute gastroenteritis is a common cause of morbi-mortality in care homes, there is no national surveillance system in France except for food-borne gastroenteritis. Since 2008, a specific surveillance system has been operating in nursing homes in Alsace, a region in eastern French. In the winter season 2009/10 we had the opportunity to study 37 outbreaks, collecting data on attack rate, duration and aetiology as well as epidemic management in nursing homes. We noticed the responsiveness of the institutions, with a mean period of 1.6 days between the onset of first symptoms and the implementation of management measures (95% confidence interval (CI): 1.0–2.2). One or several stool samples were taken in 27 of the 37 described outbreaks. The only pathogen detected was norovirus, and the positive samples were from outbreaks with a very typical pattern: vomiting in 36 of the outbreaks, a high average attack rate of 36.8% (95% CI: 31.5–42.2) and a short average duration of 8.9 days (95% CI: 5.8–7.0). No severe cases, hospitalisations or deaths were reported. The high frequency of norovirus isolation indicated that systematic bacteriological analysis in local laboratories is not cost-effective. Consequently, Cire Est recommends to test for bacteria and viruses only in cases presenting with fever or atypical symptoms. Nevertheless, Cire Est also recommends to continue sending stool samples to the French National Centre for enteric viruses, more for the benefit of the virological surveillance programme than for diagnostic purposes.
Findings in psychiatric consultations with patients with acquired immune deficiency syndrome
Authors: J W Dilley, H N Ochitill, M Perl, P A Volberding
Journal: American Journal of Psychiatry (1985)

Thirteen of 40 patients with acquired immune deficiency syndrome (AIDS) admitted to the wards of a large city hospital were seen by the staff of a psychiatric consultation service. Eleven were gay men and two were bisexual men. "Depression" was the stated reason for referral of 10 patients; of these, two met DSM-III criteria for major depression, one had dysthymic disorder, and seven had adjustment disorder with depressed mood. Recurrent psychological themes of the 13 patients were: dealing with a life-threatening illness, uncertainty about the implications of an AIDS diagnosis, social isolation, and guilt over their previous life style. The role of the primary physician and of the mental health professional in the psychological care of AIDS patients is discussed.
Induction of Atheroma in Renal Arteries of Rabbits
Authors: A OZOA, S GLAGOV
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Multidrug-resistant methicillin-resistant Staphylococcus aureus (MRSA) strain in a men-who-have-sex-with-men (MSM) community in the United States: comment
Authors: M J van de Laar, D L Monnet, M Herida
Journal: Eurosurveillance (2008)

Binary file ES_Abstracts_Final_ECDC.txt matches
Can preoperative lymphoscintigraphy be used as a guide in treatment planning of breast cancer?
Authors: AYSE MUDUN, ISIK ASLAY, MUGE AYGEN, MAHMUT MUSLUMANOGLU, YAVUZ BOZFAKIOGLU, SEMA CANTEZ
Journal: Clinical Nuclear Medicine (2001)

Purpose The purpose of this study was to map the lymphatic drainage patterns of breast cancer with lymphoscintigraphy to evaluate the variability of drainage and to determine whether lymphatic mapping can help to increase the certainty of breast cancer staging. Materials and Methods Fifty women with breast cancer (mean age, 49 years) were included in the study. Lymphoscintigraphy was performed with 1 mCi Tc-99m rhenium sulfide colloid in a 2-ml volume injected into the four quadrants of the peritumoral area using a 25-gauge needle. Ten-minute dynamic images and 2-hour delayed static images were obtained in the anterior and lateral positions using a gamma camera with a high-resolution collimator. All patients had a modified radical mastectomy and axillary dissection. The results were evaluated with histopathologic findings of the axilla. Results Six patients had excision biopsies before surgery. Of 13 patients with centrally located tumors, 84% had axillary lymphatic drainage, whereas 53% drained to internal mammary lymphatics. Of 23 patients with outer quadrant tumors, 4 showed no lymphatic drainage and all of them had metastatic tumor in the axillary lymph nodes. Axillary drainage was seen in 82% of patients and internal mammary lymphatic drainage in 23%. Of eight patients with inner quadrant tumors, one patient with no lymphatic drainage was found to have metastases in the axilla. In this group, 62% had axillary and 50% had internal mammary lymphatic drainage, and one patient had supraclavicular drainage. Conclusions Lymphoscintigraphy indicates that drainage routes may vary, and thus it may play a guiding role in patients with breast cancer who need radiotherapy. In patients with internal mammary lymphatic drainage, the accuracy of radiotherapy planning may increase if internal mammary lymphoscintigraphy is added to the protocol. In patients with internal mammary drainage, obtaining an internal mammary lymphatic biopsy during surgery will also increase the accuracy of staging.
The tuberculosis situation in Portugal : a historical perspective to 1994
Authors: M L Antunes, A Fonseca-Antunes
Journal: Eurosurveillance (1996)

Portugal built its first tuberculosis (TB) hospital in Funchal, Madeira, in 1862. In 1899, Queen Amelia proposed and sponsored a private foundation, with clinics, hospitals, sanatoriums and preventoria, where relatives and other contacts of TB patients we
Relationship between utilization of mental health and medical services in a VA hospital
Authors: P M Massad, A N West, M J Friedman
Journal: American Journal of Psychiatry (1990)

Previous research has demonstrated a reduction in utilization of medical services following the initiation of psychiatric services for certain patients. The phenomenon has been called the offset effect. The authors investigated the offset effect in a Veterans Administration medical center setting. They found that the offset effect emerged only for patients who had high rates of use of medical services who received mental health services for 1 year or less. They discuss factors related to higher rates of medical care utilization as well as important differences between the present and previous research that require further study.
Case 15-1989
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Richard W. Erbe, Carolyn C. Compton
Journal: New England Journal of Medicine (1989)

Presentation of CaseA 52-year-old man was admitted to the hospital because of neurofibromatosis complicated by weight loss, jaundice, and an ampullary mass.The patient had been mentally retarded since childhood. Cutaneous lesions were present since the age of 10 to 15 years. He was raised by his father, who never brought him to medical attention. The patient was not employed and resided with his father until three years before entry, when his sister assumed his care after the father's death.Soon thereafter the sister brought the patient to the Neurofibromatosis Clinic at this hospital, where examination showed café au . . .
Abstract POSTER-THER-1409: Targeting p53-FoxM1 axis in ovarian cancer
Authors: Xuan Zhang, Lihua Cheng, Kay Minn, Magdalena Waggoner, Nikhil K. Parelkar, Iman Jokar, George A. Vielhauer, Rashna Madan, Andrew K. Godwin, Viji Shridhar, Jeremy Chien
Journal: Clinical Cancer Research (2015)

Abstract FoxM1, a member of the Forkhead transfection factors, has been found to be overexpressed in many human cancers including ovarian cancer. Although FoxM1 is known to be downregulated by p53, the molecular mechanisms are not well characterized. In this study, we used the MDM2 inhibitor Nutlin-3 as a tool to modulate p53 expression and investigated the mechanism by which p53 regulates FoxM1 expression in ovarian cancer cells. We observed that Nutlin-3 upregulated p53 protein and downregulated FoxM1 mRNA and protein levels in ovarian cancer cell lines with wild type TP53, but not in cell lines with mutant TP53. This effect was at least partially blocked by cycloheximide or actinomycin D, indicating a transcription- and translation-dependent mechanism. Pulse-chase studies revealed that downregulation of FoxM1 by Nutlin-3 is due to enhanced FoxM1 mRNA decay. Knockdown of p53 using shRNAs abrogated the suppression of FoxM1 expression by Nutlin-3, indicating a p53-dependent mechanism. Furthermore, silencing of FoxM1 by shRNAs in ovarian cancer cells with or without wild-type TP53 led to a significant decrease in cell proliferation. The FoxM1 inhibitor, thiostrepton, induces cytotoxicity in ovarian cancer cell lines and enhances sensitivity to cisplatin in these cells. Thiostrepton downregulates FoxM1 expression in several ovarian cancer cell lines and enhances sensitivity to carboplatin in vivo. Finally, FoxM1 expression is elevated in nearly all (47/48) ovarian tumors. In summary, the present study provides novel evidence that p53 downregulates FoxM1 in ovarian cancer cells at least in part by destabilizing FoxM1 mRNA and that FoxM1 may be targeted for therapeutic benefits in ovarian cancer. Citation Format: Xuan Zhang, Lihua Cheng, Kay Minn, Magdalena Waggoner, Nikhil K. Parelkar, Iman Jokar, George A. Vielhauer, Rashna Madan, Andrew K. Godwin, Viji Shridhar,, Jeremy Chien. Targeting p53-FoxM1 axis in ovarian cancer [abstract]. In: Proceedings of the 10th Biennial Ovarian Cancer Research Symposium; Sep 8-9, 2014; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(16 Suppl):Abstract nr POSTER-THER-1409.
Leprosy as a Cause of Distal Symmetric Polyneuropathy
Authors: Joel D. Brown
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Epidemiology of Obesity and Diabetes and Their Cardiovascular Complications
Authors: Shilpa N. Bhupathiraju, Frank B. Hu
Journal: Circulation Research (2016)

Obesity and diabetes mellitus have reached epidemic proportions in the past few years. During 2011 to 2012, more than one-third of the US population was obese. Although recent trend data indicate that the epidemic has leveled off, prevalence of abdominal obesity continues to rise, especially among adults. As seen for obesity, the past few decades have seen a doubling of the diabetes mellitus incidence with an increasing number of type 2 diabetes mellitus cases being diagnosed in children. Significant racial and ethnic disparities exist in the prevalence and trends of obesity and diabetes mellitus. In general, in both adults and children, non-Hispanic blacks and Mexican Americans seem to be at a high risk than their non-Hispanic white counterparts. Secular changes in agricultural policies, diet, food environment, physical activity, and sleep have all contributed to the upward trends in the diabesity epidemic. Despite marginal improvements in physical activity and the US diet, the food environment has changed drastically to an obesogenic one with increased portion sizes and limited access to healthy food choices especially for disadvantaged populations. Interventions that improve the food environment are critical as both obesity and diabetes mellitus raise the risk of cardiovascular disease by ≈2-fold. Among those with type 2 diabetes mellitus, significant sex differences occur in the risk of cardiovascular disease such that diabetes mellitus completely eliminates or attenuates the advantages of being female. Given the substantial burden of obesity and diabetes mellitus, future research efforts should adopt a translational approach to find sustainable and holistic solutions in preventing these costly diseases.
An Undergraduate Medical School at Oxford
Authors: G. H. Bateman, N. Hobhouse, G. E. Beaumont, T. Hunt, D. Brinton, G. L. M. McElligott, W. D. W. Brooks, G. E. Neligan, L. R. Broster, W. H. Ogilvie, L. G. Brown, R. S. B. Pearson, M. Campbell, W. J. Pearson, J. J. Conybeare, J. H. Peel, E. A. Crook, A. E. Porritt, P. G. Doyne, M. Shaw, T. East, E. B. Strauss, C. Flemming, C. P. Symonds, M. L. Formby, H. Tidy, C. M. H. Howell, O. L. V. de Wesselow
Journal: BMJ (1945)
The "Moonies": a psychological study of conversion and membership in a contemporary religious sect
Authors: M Galanter, R Rabkin, J Rabkin, A Deutsch
Journal: American Journal of Psychiatry (1979)

The authors undertook this study to enhance psychiatric understanding of contemporary charismatic religious sects. After a pilot study, a representative sample of members of the Unification Church (N = 237) completed a 216-item structured questionnaire. Respondents were below the mean for an age- and sex-matched group on a psychological general well-being scale, and they reported significantly greater neurotic distress before conversion. The authors discuss correlates of an improved emotional state following conversion and employ attribution theory, drawn from social psychology, to put the conversion process into a psychiatric perspective.
Meperidine-induced delirium
Authors: S J Eisendrath, B Goldman, J Douglas, L Dimatteo, C Van Dyke
Journal: American Journal of Psychiatry (1987)

Despite the widespread use of meperidine as an analgesic, its potential for producing delirium has been overlooked. Six cases demonstrating meperidine-induced behavioral toxicity are reported. Toxicity was more likely when meperidine was combined with cimetidine or drugs having anticholinergic activity. Discontinuation of meperidine and substitution of morphine for analgesia were usually successful in treating the delirium. Physostigmine reversed the delirium in one patient. The authors suggest that the delirium results from the excessive anticholinergic activity of meperidine or its only active metabolite, normeperidine.
Bendamustine and Rituximab Achieve a Major Survival Improvement Of Patients With Morbus Waldenström In Routine Care
Authors: Rudolf Weide, Stefan Feiten, Vera Friesenhahn, Jochen Heymanns, Kristina Kleboth, Jörg Thomalla, Christoph van Roye, Hubert Köppler
Journal: Blood (2013)
Soundings: I don't know much, but this I do know
Authors: Liam Farrell
Journal: BMJ (2004)

My practice is only a stone's throw (medium sized stone, choose one with a rough texture for an easy grip, use an overhand cast—you learn about these things growing up in Ulster) from the border with the Republic of Ireland, and was particularly hard hit by the Troubles. Deprivation, unemployment, and despair were a lethal cocktail, and after seeing so many young lives wrecked I am a confirmed pacifist. Violence begets violence, and perceived injustice and repression is the best recruiting programme any paramilitary organisation could desire.

I know too little about the Iraq war for my opinion to be worth anything; it doesn't help that I don't believe anything I read any more. I have learnt from my experience in Ulster that anyone close enough to the situation to really know what's going on is too close to be objective, while anyone distant enough to be objective is also too distant to really know what's going on. An informed yet objective opinion is rare, and when it does appear is impossible to pick out against all the other plausibly argued but unbalanced opinions.

Saddam was obviously not a benevolent ruler, and just because there are so many other tyrannical regimes in the world doesn't mean it wasn't right to terminate this one. But it's an ill wind; prosperous godfathers were a feature of the Troubles in Ireland as well, and, as usual, in Iraq those who pulled the first trigger were sitting safely with scarlet majors at the base.

Hypothetically the man who declares war should be the first one over the top. Dealing death is much more antiseptic when you are thousands of miles away; you don't actually understand what it is you do, you don't see a young man's head exploding, you don't smell burnt flesh, you don't comprehend the thousands of individual tragedies.

I may know little about Iraq, but practising medicine in Ulster has given me some hard-earned insight into the cause and cure of terrorism; I've seen too many of those individual tragedies at painfully close quarters. The only true war on terror will be a war on poverty, ignorance, and injustice. It will be a long war, and it won't be a war that will make viewer-friendly headlines on CNN, but it is the only war which will have any chance of success.
Abstract 391: Cardiac Effects of Attenuating Gs{alpha}- dependent Signaling
Authors: Celine Johanssen, Marcus Streit, Marco Hagenmuller, Sebastian J Buss, David Wolf, Hugo A Katus, Stefan E Hardt
Journal: Circulation (2008)

Background: Inhibition of β-adrenergic signaling plays a key role in treatment of heart failure. GSα (excitatory subunit of Gα-protein) is essential for β-adrenergic signal transduction. Transgenic...
Narrative Review: Clarkson Disease-Systemic Capillary Leak Syndrome
Authors: Kirk M. Druey, Philip R. Greipp
Journal: Annals of Internal Medicine (2010)

In 1960, Dr. Bayard Clarkson described a patient experiencing sporadic episodes of hypovolemia, hypotension, and edema. Plasma during the acute attack induced a “shock”-like syndrome when given systemically in rats. The unusual and enigmatic “Systemic Capillary Leak Syndrome” (SCLS) named for Dr. Clarkson is of unknown etiology and is characterized by transient, severe, reversible hemoconcentration and hypoalbuminemia due to leakage of fluids and macromolecules (up to 900 kDa) into tissues (1). Fewer than 150 cases of SCLS have been reported since 1960, but the nonspecific presenting symptoms and signs and high mortality rate may have resulted in under-recognition of this disorder. Given the substantial overlap of SCLS with other “shock” syndromes, including sepsis, anaphylaxis, and angioedema, clinicians should consider this diagnosis in patients with unexplained edema, increased hematocrit, and hypotension.
Hepatocarcinogenesis by Diethylnitrosamine in Rats Fed High Dietary Levels of Lipotropes2
Authors: Lionel A. Poirier
Journal: JNCI Journal of the National Cancer Institute (1975)

The effects of high dietary levels of lipotropes on the carcinogenic activity of diethylnitrosamine (DENA) in rats were studied. All animals given DENA, with or without a dietary supplement, developed hepatocellular carcinomas. The mean survival times of all groups of rats dying with hepatocellular carcinomas after DENA treatment were determined. Choline, betaine, and folic acid consistently exerted no significant effect on those mean survival times. In rats receiving approximately equal to 2 mg DENA/day, methionine administration led to a slight but significant increase in the mean survival time of the carcinogen-treated rats, whereas vitamin B12 significantly lowered the survival time; neither substance altered the mean survival times of those treated with only 1.0 mg DENA/day. On the other hand, ethanolamine decreased the mean survival times of rats given 1.0 mg DENA daily, but had no effect on animals receiving 2 ml/day of carcinogen. Dimethylthetin (sulfur analogue of betaine), methotrexate, lecithin, and cephalin exerted no effect on the carcinogenic activity of DENA. The administration of dimethylthetin and betaine along with DENA led to markedly increased liver weights in animals dying of hepatocellular carcinomas, when compared to liver weights of animals treated with DENA alone.
EWGLI: a European surveillance scheme for travel associated legionnaire’s disease
Authors: E. J. Hutchinson, C Joseph, C L R Bartlett
Journal: Eurosurveillance (1996)

The European Working Group for Legionella Infections (EWGLI) was set up in 1986 and introduced the European Surveillance Scheme for Travel Associated Legionnaires’ Disease in 1987. The microbiologists working in reference laborat-ories and the epidemiolog
MYD88 Negative Waldenstrom Macroglobulinemia Has Distinct Clinical &amp; Biological Features As Compared To Its MYD88 Mutant Counterpart
Authors: Nikhil V Patkar, Prashant Deshpande, Russel Mascarenhas, PG Subramanian, Prashant Tembhare, Bhausaheb Bagal, Sumeet Gujral, Manju Sengar, Hari Menon
Journal: Blood (2013)
The hypothalamic-pituitary-adrenal system in panic disorder
Authors: S Goldstein, U Halbreich, G Asnis, J Endicott, J Alvir
Journal: American Journal of Psychiatry (1987)

The authors evaluated 24 outpatients with panic disorder by means of the afternoon continuous test for cortisol and the 1-mg dexamethasone suppression test (DST) and compared the results with those of 38 outpatients with major depressive disorder and 61 healthy control subjects. The mean basal cortisol level of the patients with panic disorder was significantly higher than that of the normal control subjects but almost identical to that of the depressed patients. Only three of the patients with panic disorder had abnormal DST results. These results indicate that patients with panic disorder have an abnormality of at least one function of the hypothalamic-pituitary-adrenal system which overlaps the abnormality in major depressive disorder.
Impact Of Conditioning Regimen, Donor Source, and DIPSS Score On Outcome Of Allogeneic Hematopoietic Stem Cell Transplantation For Myelofibrosis
Authors: Nicolaus Kröger, Markus Ditschkowski, Bart L Scott, Tatjana Zabelina, Haefaa Alchalby, Dietrich Beelen, H. Joachim Deeg
Journal: Blood (2013)