tbuckley/cabot-search huggingface dataset:
Tumor Tissue as a Site for Interstrain Tumor Transplantation in Mice
Authors: Richard A. Malmgren, Michael Klein, Richmond T. Prehn
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Tumor Tissue as a Site for Interstrain Tumor Transplantation in Mice Get access Richard A. Malmgren, Richard A. Malmgren Search for other works by this author on: Oxford Academic PubMed Google Scholar Michael Klein, Michael Klein Search for other works by this author on: Oxford Academic PubMed Google Scholar Richmond T. Prehn Richmond T. Prehn National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 4, February 1953, Pages 883–888, https://doi.org/10.1093/jnci/13.4.883 Published: 01 February 1953 Article history Received: 23 September 1952 Published: 01 February 1953
Abstract P1-14-12: Validation of residual cancer burden index (RCB) as a prognostic tool in patients with early breast cancer (EBC) treated with neoadjuvant chemotherapy (NAC): Comparison of RCB and Miller &amp; Payne system (M&amp;P)
Authors: V Pons, O BurguÉs, JA PÉrez-Fidalgo, MT MartÍnez, K Pinilla, B Bermejo, A Lluch
Journal: Cancer Research (2016)

Abstract Pathological evaluation of response after NAC is a controversial issue. M&amp;P has been for years the most widely employed score. Recently RCB index, a new system including axillary evaluation, seems to improve prognostic discrimination. PURPOSE: The aim of this study was to validate the RCB index as a method to define prognosis in a reallife cohort of EBC patients treated with NAC and compare it to M&amp;P system. METHODS: We performed a retrospective analysis of our database. Patients with stage I-III considered candidate for NAC between January 2003 and August 2011 were included. RCB and M&amp;P were calculated as previously published. Hormone receptor expression (RH), and Her2 were assessed following international guidelines. The Harell c-index and Roc curves were used to compare the prognostic value of RCB and M&amp;P. Clinical, therapeutic and pathological data were obtained from medical records. A correlation with disease-free survival (DFS) and overall survival (OS) was done using the Kaplan-Meier method and Cox regression model. RESULTS: 333 patients were included in this study. Distribution of breast cancer subtypes was: luminal 50.9%, Her2+ 31% and triple negative 18.1%. Mean tumour size was 42.3 mm. The majority of the patients had histhological grade II-III tumours (87.3%), with N stage 0-1 (97.3%). 87.4% received anthracycline and taxane-based NAC, associated to trastuzumab in her 2+ patients. Pathological complete response was 14% for the global population, being 30% for TN and 21.3% Her2+ subtypes. With a median follow-up of 56.3 months, DFS and OS at 5 years were as follows: RCB-0 93.6% and 97.9%, RCB-I 84.2% and 98.2%, RCB-II 79.1% and 89.5%, RCB-III 38.3% and 63.6%. Harell c-index value of RCB was statistically superior to M&amp;P in both DFS (0.80 vs 0.68, p= 0.001) and OS (0.87 vs 0.69, p&amp;lt;0.001 ). This superiority value of RCB was consistent among all breast cancer subtypes. CONCLUSION: RCB index is as more accurated prognostic score to predict DFS and OS compared to M&amp;P. Citation Format: Pons V, BurguÉs O, PÉrez-Fidalgo JA, MartÍnez MT, Pinilla K, Bermejo B, Lluch A. Validation of residual cancer burden index (RCB) as a prognostic tool in patients with early breast cancer (EBC) treated with neoadjuvant chemotherapy (NAC): Comparison of RCB and Miller &amp; Payne system (M&amp;P). [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-14-12.
Effect of phototherapy on spontaneous eye blink rate in subjects with seasonal affective disorder
Authors: R A Depue, W G Iacono, R Muir, P Arbisi
Journal: American Journal of Psychiatry (1988)

Eye blink rate was measured in four subjects with seasonal affective disorder and in four control subjects before and after phototherapy. The subjects with seasonal disorder blinked twice as often as the control subjects before therapy but no differently after phototherapy.
Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD
Authors: João Sabino, Sara Vieira-Silva, Kathleen Machiels, Marie Joossens, Gwen Falony, Vera Ballet, Marc Ferrante, Gert Van Assche, Schalk Van der Merwe, Severine Vermeire, Jeroen Raes
Journal: Gut (2016)

<h3>Objective</h3> Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often leading to end-stage liver disease. Its pathogenesis remains largely unknown, although frequent concomitant IBD hints towards common factors underlying gut and bile duct inflammation. Considering the mounting evidence on the involvement of the intestinal microbiota in initiating and determining IBD phenotype, we investigated intestinal microbiota composition in patients with PSC. <h3>Design</h3> Stool samples were collected from 147 individuals (52 patients with PSC, 52 age, gender and body mass index-matched healthy volunteers, 13 UC and 30 patients with Crohn9s disease). An independent validation cohort of 14 PSC and 14 matched controls was recruited. 16S rDNA sequencing of faecal DNA was performed (Illumina MiSeq). <h3>Results</h3> The microbiota of patients with PSC was characterised by decreased microbiota diversity, and a significant overrepresentation of <i>Enterococcus</i> (p=3.76e-05), <i>Fusobacterium</i> (p=3.76e-05) and <i>Lactobacillus</i> (p=0.0002) genera. This dysbiosis was present in patients with PSC with and without concomitant IBD and was distinct from IBD, and independent of treatment with ursodeoxycholic acid. A decision tree based on abundances of these three genera allowed reliable classification in the validation cohort. In particular, one operational taxonomic unit belonging to the <i>Enterococcus</i> genus was associated with increased levels of serum alkaline phosphatase (p=0.048), a marker of disease severity. <h3>Conclusions</h3> We here present the first report of PSC-associated faecal dysbiosis, independent from IBD signatures, suggesting the intestinal microbiota could be a contributing factor in PSC pathogenesis. Further studies are needed to confirm these findings and assess causality.
424PD Individualization of docetaxel (DTX) treatment in East-Asian advanced non-small cell lung cancer (NSCLC) patients based on pharmacokinetically (PK)-guided dosing strategy: an open-label randomized clinical trial
Authors: Y. Ma, Y. Lin, Y. li, H. Zhao, Y. Zhang, J. Sheng, Y. Yang, Y. Huang, L. Zhang
Journal: Annals of Oncology (2015)
The Effect of Weight Reduction on the Occurrence of Spontaneous Mammary Tumors in Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Samuel H. Waxler
Journal: JNCI Journal of the National Cancer Institute (1954)

The Effect of Weight Reduction on the Occurrence of Spontaneous Mammary Tumors in Mice Get access Samuel H. Waxler Samuel H. Waxler Department of Pharmacology and Therapeutics, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 6, June 1954, Pages 1253–1256, https://doi.org/10.1093/jnci/14.6.1253 Published: 01 June 1954 Article history Received: 19 January 1954 Published: 01 June 1954
Inflammation and Arterial Injury in Individuals With Human Immunodeficiency Virus Infection
Authors: James H. Stein, Priscilla Y. Hsue
Journal: JAMA Cardiology (2016)

Markella V. Zanni, MD; Mabel Toribio, MD; Gregory K. Robbins, MD; Tricia H. Burdo, PhD; Michael T. Lu, MD; Amorina E. Ishai, MD; Meghan N. Feldpausch, NP; Amanda Martin, AB; Kathy Melbourne, PharmD; Virginia A. Triant, MD, MPH; Sujit Suchindran, MD; Hang Lee, PhD; Udo Hoffmann, MD, MPH; Kenneth C. Williams, PhD; Ahmed Tawakol, MD; Steven K. Grinspoon, MD
Prazosin
Authors: Jan Koch-Weser, Robert M. Graham, William A. Pettinger
Journal: New England Journal of Medicine (1979)

PRAZOSIN (l-[4-amino-6,7-dimethoxy-2-quinazoline]-4-[2-furoyl]-piperazine) (Fig. 1), the first of a new class of antihypertensive agents, was released for clinical use in the United States in 1976.1 Although it has been used effectively as a single agent, its widest application is in combination with other drugs in the therapy of patients with chronic hypertension. Preliminary data suggest that prazosin may also have a role in the therapy of severe congestive heart failure by effecting a reduction in cardiac pre-load and after-load.Site and Mechanism of ActionPrazosin exerts its hypotensive action by reducing peripheral vascular resistance as a consequence of blockade of vascular . . .
THE INNERVATION OF THE ORBICULARIS ORIS MUSCLE
Authors: L. J. Kidd
Journal: BMJ (1912)

Massive pulmonary embolism was confirmed by pulmonary arteriography in 23 patients. All were seen between 2 and 48 hours after the onset of embolism and none had pre-existing cardiorespiratory disease. Fifteen were treated with streptokinase and eight with heparin. Factors which might influence prognosis and rate of resolution were similar in the patients in each group, and there was no significant difference between the groups in terms of pretreatment haemodynamic or arteriographic findings. Haemodynamic and arteriographic findings after treatment for 72 hours provided an objective measurement of resolution, which was significantly greater in the streptokinase-treated patients. There was no mortality in either group, but treatment had to be changed in two heparin-treated patients because of clinical deterioration. The principal complication of treatment, seen more often in the streptokinase-treated patients, was bleeding from cut-down or operation sites.
Surveillance Imaging in Patients in Remission From Hodgkin and Diffuse Large B-Cell Lymphoma
Authors: Chadi Nabhan, Sonali M. Smith, Adam S. Cifu
Journal: JAMA (2016)

This JAMA Clinical Guidelines Synopsis summarizes the National Comprehensive Cancer Network’s and European Society of Medical Oncology’s recent recommendations on follow-up imaging in patients in remission from Hodgkin and diffuse large B-cell lymphoma.
Identification and Expression Analysis of EST-Based Genes in the Bud of <i>Lycoris Longituba</i>
Authors: Yonglan Cui, Xinye Zhang, Yan Zhou, Hong Yu, Lin Tao, Lu Zhang, Jian Zhou, Qiang Zhuge, Youming Cai, Minren Huang
Journal: Genomics Proteomics & Bioinformatics (2004)

Abstract To obtain a primary overview of gene diversity and expression pattern in Lycoris longituba, 4,992 ESTs (Expressed Sequence Tags) from L. longituba bud were sequenced and 4,687 cleaned ESTs were used for gene expression analysis. Clustered by the PHRAP program, 967 contigs and 1,343 singlets were obtained. Blast search showed that 179 contigs and 227 singlets (totally 1,066 ESTs) had homologues in GenBank and 3,621 ESTs were novel.
TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
Authors: Peng Yuan, Carlo Condello, C. Dirk Keene, Yaming Wang, Thomas D. Bird, Steven M. Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendler
Journal: Neuron (2016)
Life events of adolescents in relation to personal and parental substance abuse
Authors: S A Brown
Journal: American Journal of Psychiatry (1989)

The author examined the life events reported by 138 adolescents in relation to their own and their parents' alcohol and/or drug use. The 62 adolescents who were substance abusers reported more negative events involving deviance and emotional distress and evaluated the life events they experienced as less desirable than did the 76 nonabusing adolescents. Substance-abusing adolescents and the 31 nonabusing adolescents with substance-abusing parents experienced comparable numbers of stressful life experiences; however, the type and qualitative features of the events differed. Adolescents with substance abuse in only one family generation experienced more emotional distress than those with substance use patterns consistent across generations.
Clinical significance of pulse pressure in patients with heart failure with preserved left ventricular ejection fraction
Authors: Takanori Tokitsu, Eiichiro Yamamoto, Yoshihiro Hirata, Hiroaki Kusaka, Koichiro Fujisue, Daisuke Sueta, Koichi Sugamura, Kenji Sakamoto, Kenichi Tsujita, Koichi Kaikita, Seiji Hokimoto, Seigo Sugiyama, Hisao Ogawa
Journal: European Journal of Heart Failure (2016)
Gene expression profiling predicts clinical outcome of prostate cancer
Authors: Gennadi V. Glinsky, Anna B. Glinskii, Andrew J. Stephenson, Robert M. Hoffman, William L. Gerald
Journal: Journal of Clinical Investigation (2004)

One of the major problems in management of prostate cancer is the lack of reliable genetic markers predicting the clinical course of the disease. We analyzed expression profiles of 12,625 transcripts in prostate tumors from patients with distinct clinical outcomes after therapy as well as metastatic human prostate cancer xenografts in nude mice. We identified small clusters of genes discriminating recurrent versus nonrecurrent disease with 90% and 75% accuracy in two independent cohorts of patients. We examined one group of samples (21 tumors) to discover the recurrence predictor genes and then validated the predictive power of these genes in a different set (79 tumors). Kaplan-Meier analysis demonstrated that recurrence predictor signatures are highly informative (P < 0.0001) in stratification of patients into subgroups with distinct relapse-free survival after therapy. A gene expression–based recurrence predictor algorithm was informative in predicting the outcome in patients with early-stage disease, with either high or low preoperative prostate-specific antigen levels and provided additional value to the outcome prediction based on Gleason sum or multiparameter nomogram. Overall, 88% of patients with recurrence of prostate cancer within 1 year after therapy were correctly classified into the poor-prognosis group. The identified algorithm provides additional predictive value over conventional markers of outcome and appears suitable for stratification of prostate cancer patients at the time of diagnosis into subgroups with distinct survival probability after therapy.
Erythematous nodes, urticarial rash and arthralgias in a large pedigree with <i> <scp>NLRC</scp> 4 </i> ‐related autoinflammatory disease, expansion of the phenotype
Authors: C.M.L. Volker‐Touw, H.D. Koning, J. C. Giltay, C.G.F. Kovel, T.S. Kempen, K.M.E.J Oberndorff, M.L. Boes, M.A.M. Steensel, G.T.J. Well, W.A.M. Blokx, J. Schalkwijk, A. Simon, J. Frenkel, M.E. Gijn
Journal: British Journal of Dermatology (2016)

Linked Comment: Barzilai and Cohen. Br J Dermatol 2017; 176:18–19.
Psychiatric consultation to a state board of medical examiners
Authors: J D Bloom, M Resnick, J J Ulwelling, J H Shore, M H Williams, C Rhyne
Journal: American Journal of Psychiatry (1991)

This article describes the evolution of psychiatric consultation to the Oregon Board of Medical Examiners. The board is charged with the licensing and regulation of physicians in the state of Oregon in order to protect the public and uphold the standards of the medical profession. Psychiatric consultation has focused on the board's investigations of physicians with mental illness and/or substance abuse and physicians who inappropriately prescribe psychoactive drugs or sexually abuse patients. Each of these physician groups is described, and remedial programs for each group are discussed. The authors conclude that psychiatric consultation to medical boards is a feasible and productive activity that can make a positive contribution to the lives of a large number of physicians and patients.
LNK mutations in familial myeloproliferative neoplasms
Authors: Elisa Rumi, Ashot S. Harutyunyan, Daniela Pietra, Jelena D. Milosevic Feenstra, Chiara Cavalloni, Elisa Roncoroni, Ilaria Casetti, Marta Bellini, Chiara Milanesi, Maria C. Renna, Manuel Gotti, Cesare Astori, Robert Kralovics, Mario Cazzola
Journal: Blood (2016)
Human Births and the Phase of the Moon
Authors: G O Abell, B Greenspan
Journal: New England Journal of Medicine (1979)

Published studies on the frequency of births as related to the lunar cycle are inconsistent with each other. The distribution of all births during 51 lunar cycles, from March 17, 1974, to April 30, 1978, was analyzed by the authors at the University of California, Los Angeles, Hospital. There were 11.691 live births, of which 8142 were natural, 141 multiple, and 168 stillbirths. In none of the 4 samples was the mean number of births occurring on the date of the full moon above average, showing that the birthrate during the period surveyed did not in any way correlate with the cycle of lunar phases.
Developmental Therapeutics for Myelodysplastic Syndromes
Authors: Aung Naing, Lubomir Sokol, Alan F. List
Journal: Journal of the National Comprehensive Cancer Network (2006)

The management strategy for patients with myelodysplastic syndromes (MDS) has evolved from sole reliance on supportive measures to active treatment guided by disease risks. Recent progress in understanding the molecular pathogenesis of MDS has accelerated the discovery of new therapeutic targets, and consequently launched the development of several novel therapeutics that are currently in varied stages of clinical testing. One such agent is lenalidomide, which has shown remarkable effectiveness in the cytogenetically defined subset of MDS with the chromosome 5q31 deletion. The advent of new and effective targeted therapeutics may beneficially affect outcomes of an ever-increasing number of patients with MDS. This discussion summarizes the preliminary results of selected novel therapeutics.
The prognostic relevance of delusions in depression: a follow-up study
Authors: R L Kettering, M Harrow, L Grossman, H Y Meltzer
Journal: American Journal of Psychiatry (1987)

To determine whether delusional depression has a different clinical course from other types of depression, the authors followed up 31 unipolar delusional depressed patients, 28 unipolar nonpsychotic depressed patients, and 51 schizophrenic patients 14 months after hospital discharge. Patients were assessed on 1) overall outcome, 2) psychotic, anxiety-neurotic, and depressive symptoms, 3) social and work functioning, and 4) rehospitalization. The delusional depressed patients showed significantly more mood-incongruent delusions at follow-up. Surprisingly, the nonpsychotic depressed patients exhibited more depressed mood and significantly more anxiety at follow-up. The findings suggest that the diagnostic distinction between delusional and nonpsychotic depression is relevant to the clinical course of major depression.
Brief Communication: Resistance to Skin Tumorigenesis by 3-Methylcholanthrene in Mice Susceptible to Leukemia2
Authors: Maria L. Duran-Reynals, Christine Cook
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Brief Communication: Resistance to Skin Tumorigenesis by 3-Methylcholanthrene in Mice Susceptible to Leukemia Get access Maria L. Duran-Reynals, Maria L. Duran-Reynals Search for other works by this author on: Oxford Academic PubMed Google Scholar Christine Cook Christine Cook 3Department of Pathology, Albert Einstein College of Medicine, Bronx, N.Y. 10461 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 3, March 1974, Pages 1001–1003, https://doi.org/10.1093/jnci/52.3.1001 Published: 01 March 1974 Article history Received: 19 November 1973 Accepted: 07 December 1973 Published: 01 March 1974
Abstract P3-07-59: Stem cell markers are overexpressed in tumorspheres cultured from circulating epithelial tumor cells (CETCs) in patients with breast cancer
Authors: D Zimon, M Pizon, V Mayer, K Pachmann
Journal: Cancer Research (2016)

Abstract Background: Breast malignancies continuously shed tumor cells which may enter the circulation, spread to other tissue and initiate metastases, but only a small subpopulation among CETCs is capable of metastasis formation. The subpopulation of CETC capable of forming tumorspheres in vitro and carrying stem cells properties is assumed to have metastatic potential. The aim of this study was to characterize the pattern of expression of the tumorspheres as compared to CETCs. Methods: Blood samples were obtained from patients diagnosed with breast tumors. CETCs were enumerated with maintrac method and subsequently cultivated in stem cell-selective medium. The expression of stem cell marker genes EpCAM, Nanog, Okt4 Sox2, ALDH and CD133 were detected by RT-PCR in single CETCs and tumorspheres. Results: 0.1- 10% of CETCs could form non-adherent tumorspheres under stem cell- selective conditions after a period of 14 days. Array qRT-PCR analysis revealed that putative stem cell markers, such as Oct4, Sox2, Nanog, EpCAM, ALDH1 and CD133 are overexpressed in relation to house-keeping genes RPL13a and GAPDH in tumor spheres in contrast to the significantly lower expression level of these stem cell markers in individually isolated CETCs. High expression level of pluripotency genes in tumorspheres was associated with aggressive tumor behaviour in terms of tumor progression and type of cancer. Conclusion: Thus, differential expression of stem cell markers in CETCs and tumorspheres substantiates the hypothesis that only a small population of circulating tumor cells possess the stem cell properties and are responsible for metastasis formation. Citation Format: Zimon D, Pizon M, Mayer V, Pachmann K. Stem cell markers are overexpressed in tumorspheres cultured from circulating epithelial tumor cells (CETCs) in patients with breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-07-59.
History of the Life of D. Hayes Agnew, M.D., LL.D.
Journal: JAMA (1896)

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