tbuckley/cabot-search huggingface dataset:
Abstract P3-07-10: Effect of lifestyle and single nucleotide polymorphisms on breast cancer risk: A case-control study in Japanese women
Authors: T Mizoo, N Taira, K Nishiyama, T Nogami, T Iwamoto, T Motoki, T Shien, J Matuoka, H Doihara, S Ishihara, N Kawai, K Kawasaki, Y Ishibe, Y Ogasawara
Journal: Cancer Research (2012)

Abstract [Background] Lifestyle, including diet and physical activity, and birth/breastfeeding history are known to affect the risk for breast cancer. A correlation between single nucleotide polymorphisms (SNPs) and breast cancer risk has also been suggested in some reports, but the gene-environment interaction with breast cancer risk has not been examined widely. [Methods] The subjects were 476 breast cancer patients and 528 controls who attended a health check and had no history of breast cancer. Lifestyle was examined using a questionnaire with 48 questions about diet, physical activity, smoking habits, alcohol intake, and birth/breastfeeding history, etc. Based on past reports, we analyzed 6 SNPs (TNRC9-rs3803662, LSP1/11q-rs3817198, MAP3K1-rs889312, 8q24-rs13281615, 5p12-rs981782, and TGFβ1-rs1800470) using blood samples, and calculated age-adjusted odds ratios in a multiple logistic regression analysis. [Results] The study was performed from December 2010 to November 2011. Lifestyle factors (age-adjusted odds ratio, [95% confident interval]) found to have a significant correlation with development of breast cancer included BMI (1.041, [1.00–1.08]), smoking history (2.28, [1.45–3.65]), small number of births (1.18, [1.05–1.34]), no exercise during leisure time (1.36, [1.06–1.77]), low intake of green and yellow vegetables (1.69, [1.01–2.85]), and low intake of mushrooms (1.58, [1.05–2.39]). Stratified analysis based on menopause status showed that smoking history (1.85, [1.00–3.49]) and low intake of green and yellow vegetables (2.5, [1.03–5.88]) were significant risk factors before menopause, and that smoking history (2.28, [1.45–3.65]), low intake of green and yellow vegetables (2.24, [1.09–4.68]), no exercise during leisure time (1.67, [1.19–2.36]), small number of births (1.49, [1.25–1.78]), and no breastfeeding history (1.03, [1.01–1.06]) were significant risk factors after menopause. The results of SNP analysis suggested that TNRC9-rs3803662 was a significant risk factor in women before menopause (2.29, [1.25–4.25]). However, in multivariate analysis including lifestyle factors and SNPs, only smoking history emerged as a significant risk factor in women before menopause. [Conclusion] A correlation between lifestyle and breast cancer risk was found in this study, consistent with previous findings. Lifestyle and environmental factors such as births and breastfeeding may be more important than SNPs as risk factors for breast cancer. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-07-10.
Abstract 5330: Androgen independent promotion of prostate cancer cell invasion by HOXB13-mediated zinc regulation
Authors: Young-Rang Kim, In-Je Kim, Taek Won Kang, Chan Choi, Min Soo Kim, Kwang Il Nam, Chaeyong Jung
Journal: Cancer Research (2012)

Abstract A healthy prostate maintains the high level of zinc while intracellular zinc is diminished during prostate cancer (PCa) developments. However, down-regulation of intracellular zinc in PCa are not fully understood, particularly in development of hormone refractory PCa (HRPC). Our previous studies showed that HOXB13 was overexpressed in HRPC. In our attempt to profile androgen-independent HOXB13 target genes in LNCaP PCa cells by DNA microarray, most strikingly regulated gene was ZnTs, a group of zinc output transporters. HOXB13 drove PCa cells to decrease intracellular zinc concentration. In the absence of androgen, HOXB13 dramatically promoted NF-κB-mediated signaling by reduction of inhibitor of NF-κB alpha (IκBα) and correspondingly stimulated nuclear translocation of RelA/p65. HOXB13-mediated NF-κB activation was nearly eliminated by suppression of ZnT4. At the same time, prostate tumors strongly indicated inverse correlation of HOXB13 and IκBα expression. Correspondingly, HOXB13 stimulated an invasive property of LNCaP cells, which can be negated by suppression of ZnT4 in an androgen-free environment. Taken together, these results demonstrate that HOXB13 promoted PCa cell invasion in an androgen-deprived condition by decreasing intracellular zinc concentration to further stimulate NF-κB-mediated transactivation, indicating that HOXB13 overexpression contributes to the malignant biological behavior of HRPC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5330. doi:1538-7445.AM2012-5330
Treatment of Refractory Heart Failure with Infusion of Nitroprusside
Authors: Nabil H. Guiha, Jay N. Cohn, Esteban Mikulic, Joseph A. Franciosa, Constantinos J. Limas
Journal: New England Journal of Medicine (1974)

Abstract Sodium nitroprusside infused in 18 patients with intractable heart failure (nine with ischemic heart disease and nine with cardiomyopathy) produced a prompt reduction of left ventricular filling pressure (pulmonary wedge or left ventricular end-diastolic pressure) from an average of 32.2 to 17.2 mm Hg and a rise in cardiac output from an average of 2.98 to 5.2 liters per minute. Mean arterial pressure fell by 15 mm Hg, and heart rate was slightly but significantly slowed. Stroke volume and forward ejection fraction were nearly doubled. Responses were similar in ischemic heart disease and cardiomyopathy. A diuresis and natriuresis accompanied the infusion, and the clinical response was sustained in five patients in whom the drug was continued for 24 to 72 hours. These results suggest that intractable heart failure may be effectively treated by reduction in impedance to left ventricular ejection. (N Engl J Med 291:587–592, 1974)
REGIONAL CEREBRAL ACTIVITY IN NORMAL AND PATHOLOGIC PERCEPTION OF VISCERAL PAIN: AN O-15-WATER PET STUDY OF HEALTHY SUBJECTS AND IBS PATIENTS
Authors: D. H.S. Silverman, J. A. Munakata, C. K. Hoh, M. A. Mandelkern, M. E. Phelps, W. Blahd, E. A. Mayer
Journal: Clinical Nuclear Medicine (1996)

Silverman, D.; Munakata, J. A.; Hoh, C. K.; Mandelkern, M. A.; Phelps, M. E.; Blahd, W.; Mayer, E. A.Editor(s): Blend, Michael; Haseman, Michael Author Information
Potential effects of increased global temperatures on neurological development factors in children under 5 years in east Africa: a modelling study
Authors: Timothy Singer, Frances Moore, Stephen Luby
Journal: The Lancet Global Health (2016)

Background A rise in global temperatures is known to reduce calorie and nutrient availability through diminished yields and shifts in crop nutrient content. Insufficient calorie and nutrient intake can adversely affect nervous-system development in children. To quantify the effect of rising temperatures on paediatric neurological development in east Africa, we analysed total intake of calories, iron, and zinc in Kenya, Rwanda, Tanzania, and Uganda. We then used a model to predict the effect of rising temperatures on incidences of factors important for neurological development in children younger than 5 years.
PRE-HOSPITAL THROMBOLYSIS VERSUS PRIMARY PERCUTANEOUS CORONARY INTERVENTION FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN REGIONAL AUSTRALIA: REAL WORLD LONG TERM FOLLOW UP
Authors: Arshad Ameer Khan, Trent Williams, Lindsay Savage, Paul Stewart, Peter Fletcher, Andrew Boyle
Journal: Journal of the American College of Cardiology (2016)
The Effect of Cholesterol-Lowering and Antioxidant Therapy on Endothelium-Dependent Coronary Vasomotion
Authors: Todd J. Anderson, Ian T. Meredith, Alan C. Yeung, Balz Frei, Andrew P. Selwyn, Peter Ganz
Journal: New England Journal of Medicine (1995)

Patients with coronary artery disease and abnormalities of serum lipid levels often have endothelial vasodilator dysfunction, which may contribute to ischemic cardiac events. Whether cholesterol-lowering or antioxidant therapy can restore endothelium-dependent coronary vasodilatation is unknown.
Abstract 1245: Polyribosome association of tyrosine phosphorylated RACK1 with activated Src regulates translation of specific proteins mediating breast cancer growth and metastasis
Authors: Gary K. Scott, Bianca Gabriel, Jason Held, Christopher C. Benz
Journal: Cancer Research (2010)

Abstract Dysregulation of translational control, characterized by aberrant expression of proteins critical for growth and metastatic potential, is emerging as an essential aspect of tumorigenesis. Receptor for activated protein kinase C-1 (RACK1) is a scaffold protein known to coordinate the cellular localization of numerous signaling proteins including PKC and Src, and has recently been identified as an essential ribosome component binding to the head region of the 40S subunit. RACK1 was identified in a mass spectrometry screen of polyribosome proteins from human breast cancer cells demonstrating altered mobility on 2D gel electrophoresis following growth-arresting doses of a histone deacetylase (HDAC) inhibitor which suggested that post-translational modifications of ribosome associated RACK1 might selectively influence protein synthesis and cancer cell growth. Polyribosome profiling of MDA-231 and SKBR3 breast cancer cells revealed that while the entire complement of lysate soluble RACK1 was ribosome associated in both cell lines, only RACK1 from the MDA-231 cells appeared significantly tyrosine phosphorylated. Furthermore, tyrosine phosphorylated Src (pTyr-416), while 10 fold more abundant in the SKBR3 untranslated fractions relative to those from MDA-231, was associated with the polyribosome factions of MDA-231 but not those of SKBR3, consistent with previous observations linking activated Src with tyrosine phosphorylated RACK1. Lentiviral delivery of shRNA was used to investigate the functional consequences of selective RACK1 knockdown. In MDA-231 cells, efficient RACK1 knockdown produced complete growth arrest and loss of motility without induction of apoptosis or cell senescence; however, this growth arrested phenotype is associated with near complete loss of cyclin D1 and TGFbetaR1 expression without change in the expression of housekeeping proteins beta-actin and GAPDH. Taken together, these results implicate tyrosine phosphorylated RACK1 in association with polysomal pTyr-Src as translational activators of specific proteins mediating breast cancer proliferation and metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1245.
AB0689 Interstitial lung disease in severe connective tissue diseases (CTD)
Authors: M.G. Danieli, R. Moretti, S. Gambini, L. Paolini, A. Gabrielli
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> We here report the incidence, the clinical features and treatment response of interstitial lung disease (ILD) associated to idiopathic inflammatory myopathies (IIM), Sjogren’s Syndrome (SS) and systemic lupus erythematosus (SLE). <h3>Methods</h3> We reviewed the clinical notes of 224 consecutive patients followed by our department from 1990 to 2011. IIM was present in 77 patients, SS in 100 subjects and SLE was documented in 87 cases. Demographic, clinical and serological data were collected through a standardised protocol. ILD was defined by specific spirometric and tomographic patterns. <h3>Results</h3> ILD was documented in 20 (26%) patients with IIM, in 15 (15%) with SS and in 13 (15%) with SLE. All patients were treated with steroid, alone or associated with an immunosuppressant. All of them had a restrictive pattern at the pulmonary function testing with a reduced diffusing capacity for carbon monoxide. In patients with SS- and LES- associated ILD the response to the treatment was satisfactory, whereas in patients with myositis, ILD-related deaths occurred in 25% of the cases. This percentage was higher when compared to the percentage of the disease-related death (17%). <h3>Conclusions</h3> Despite major progress in the treatment, ILD in the course of CTDs remain a severe complication, significantly affecting subjects’ survival and quality of life. The relatively high frequency of asymptomatic subjects, with subclinical ILD documented by the presence of a restrictive spyrometric pattern and typical radiological features, suggests the importance of early diagnosis. <h3>Disclosure of Interest</h3> None Declared
Occult Hepatitis B Virus Infection in Patients with Chronic Hepatitis C Liver Disease
Authors: Irene Cacciola, Teresa Pollicino, Giovanni Squadrito, Giovanni Cerenzia, Maria Elena Orlando, Giovanni Raimondo
Journal: New England Journal of Medicine (1999)

Hepatitis B virus (HBV) infections in patients who lack detectable hepatitis B surface antigen (HBsAg) are called occult infections. Although such infections have been identified in patients with chronic hepatitis C liver disease, their prevalence and clinical significance are not known.
FRI0222 Prevalence of low immunoglobulin levels and associations with rheumatoid arthritis factors
Authors: D.A. Pappas, A. John, J.R. Curtis, J. Kremer, W. Reiss, A. Shewade, G.J. Silverman, J. Greenberg
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Little is known about the prevalence and the clinically associated factors of low IgG and IgM levels in patients (pts) with RA. <h3>Objectives</h3> To estimate the prevalence of low IgG and IgM levels in pts with RA and to investigate factors associated with low Ig <h3>Methods</h3> This cross-sectional analysis evaluated Ig levels measured centrally at the time of enrollment in CERTAIN, a prospective comparative effectiveness study of biologics nested within CORRONA. Multivariate models (MV) evaluated factors associated with low Ig levels. <h3>Results</h3> Characteristics for the 1151 enrollments were analyzed: 76% women, 86% Caucasian, 67% seropositive. The mean (±SD) age was 56.1 (±13.5) years, RA duration was 8.5 (±9.1) years and CDAI was 29.1 (±13.0). At the time of evaluation 35.7% of pts were biologic-naïve and 39.6% received prednisone in the last 6 months (34.8% of them ≤10mg/day). Low IgG (&lt;700mg/dl) was noted in 76 (6.6%) pts and low IgM (&lt;40mg/dl) in 63 (5.5%) pts. MV (Table 1) showed that pts with high disease activity were more likely to have low IgG. Prior exposure to biologics was not associated with low IgG or IgM. Instead, an opposite trend was suggested for prior exposure to TNF-α inhibitors. MV suggested that higher doses of prednisone are likely to be associated with low IgG levels and that seropositive pts are more likely to have normal Ig levels. <h3>Image/graph</h3> <h3>Conclusions</h3> High disease activity was associated with increased odds of low IgG. Effect of biologic agents, steroids and other factors on Ig levels, and clinical outcomes will be evaluated in a longitudinal analysis when CORRONA-CERTAIN is completed. <b>Disclosure of Interest</b>: D. Pappas Employee of: Columbia University, Paid instructor for: Novartis, A. John Employee of: Genentech, Inc., J. Curtis Grant/research support from: Roche/Genentech, UCB, Janssen, CORRONA, Amgen, Pfizer, BMS, Crescendo, Abb Vie, Consultant for: Roche/Genentech, UCB, Janssen, CORRONA, Amgen, Pfizer, BMS, Crescendo, Abb Vie, J. Kremer Shareholder of: CORRONA, Employee of: CORRONA, W. Reiss Employee of: Genentech, Inc., A. Shewade Employee of: Genentech, Inc., G. Silverman Grant/research support from: NIH, ACR, RRF, Consultant for: Lilly, Genentech, Roche, Pfizer, Employee of: New York University, J. Greenberg Shareholder of: CORRONA, Consultant for: AstraZeneca, CORRONA, Novartis, Pfizer
SHORT PR VERSUS LONG PR PREMATURE ATRIAL CONTRACTIONS ON REMOTE MONITORING AS PREDICTOR OF NON PULMONARY VEIN TRIGGERS FOLLOWING UNSUCCESSFUL ATRIAL FIBRILLATION ABLATION
Authors: Luigi Di Biase, Prasant Mohanty, Sanghamitra Mohanty, Chintan Trivedi, Carola Gianni, Rong Bai, Pasquale Santangeli, Francesco Santoro, Javier Sanchez, Rodney Horton, G. Gallinghouse, Jason Zagrodzky, Steven Hao, Salwa Beheiry, Richard Hongo, Dhanunjaya Lakkireddy, Madhu Reddy, Juan Viles-Gonzalez, John Burkhardt, Andrea Natale
Journal: Journal of the American College of Cardiology (2015)
OP0314 Body Composition and Abdominal Adiposity in Rheumatoid Arthritis Patients: Cross-Sectional Study of Patients and Controls
Authors: I. Ferraz-Amaro, E. Delgado-Frías, V. Hernández-Hernández, J. R. Muñiz-Montes, A. González-Díaz, A. Gómez Rodríguez-Bethencourt, F. Díaz-González
Journal: Annals of the Rheumatic Diseases (2013)

In this article, we propose a definition of value in Treasury bonds that, we believe, is more satisfactory than definitions found in the recent literature, and that allows for statistically significant and economically relevant predictions of cross-sectional excess returns. Our value pricing factor exploits the differences between the market and the theoretical values of Treasury bonds, where the theoretical value is assessed using an economically-justifiable Gaussian dynamic term structure model. We show that the profitability of the strategy we build using our value signal is statistically and economically significant and is closely linked to the Treasury market volatility. We provide an explanation for this strong link using arguments similar to what can be found in the recent literature on liquidity in Treasuries; and we show that our value signal is not subsumed by the best-known return-predicting factors. With an eye to practical applications, we also present a long-only version of our strategy. <b>TOPICS:</b>Analysis of individual factors/risk premia, factor-based models, style investing
Abstract 350: High-throughput drug screens identify novel synthetic lethal interactions with MLH1-deficient cancers
Authors: Madeleine Hewish, Chris J. Lord, Sarah A. Martin, David Cunningham, Alan Ashworth
Journal: Cancer Research (2011)

Abstract Mismatch Repair (MMR) deficiency occurs in some inherited and somatic malignancies as a consequence of mutation or epigenetic silencing. Since MMR-deficient tumours exhibit tolerance to many commonly used chemotherapeutic agents, there is an unmet clinical need to develop novel treatment strategies for this group of cancers. We utilized an in vitro isogenic colorectal model, the MLH1-deficient HCT116, and its isogenic comparator HCT116+Chr3, to perform high throughput screening of chemical libraries to identify novel drugs which were relatively cytotoxic to MLH1-deficient tumour cells compared with their MLH1-proficient comparators. The assay readout was cellular viability. ‘Hit’ drugs were then validated across a range of drug concentrations to determine the likelihood of ‘off target’ effects and potential clinical applicability, and further validated in clonogenic assays. Amongst the validated hits were cytosine arabinoside (ara-C), ethinyl oestradiol and desferoxamine. Ara-C was selected for further investigation and validated in two other in vitro models of MLH1 deficiency. Other nucleoside analogs were also investigated for MLH1-deficient selectivity and a lesser degree of selectivity was observed with gemcitabine. Compatible with the defective cell cycle checkpoints of MLH1-deficient cells, we have subsequently demonstrated that the excess cytotoxicity is associated with an increase in apoptosis that coincides with release from initial G1/early S phase arrest, suggesting that MLH1-deficient cells undergo mitotic catastrophe. In summary, we have used high throughput screening to identify possible new strategies for the treatment of MLH1-deficient cancers. Further mechanistic studies are ongoing. Combinations of drugs known to be MLH1-deficient selective are also being tested with a view to increasing the therapeutic window of a possible MLH1-deficient therapeutic strategy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 350. doi:10.1158/1538-7445.AM2011-350
Seroreactivity Against Epstein-Barr Virus (Ebv) in Family Members of Ebv-Associated Nasopharyngeal Carcinoma and Non-Family Individuals
Authors: S.H. Hutajulu, G.-. Argy, C.-. Herdini, B.-. Hariwiyanto, B.R. Jati, S.M. Haryana, J.-. Fachiroh, J.M. Middeldorp
Journal: Annals of Oncology (2014)
AB1039 French rheumatologists and patients education (PE) in osteoporosis (ETOP study)
Authors: R.-L. Dreiser, M. Guilaume
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The fact that osteoporosis is a chronic disease and that the evolution of the doctor – patient's relationship goes towards a stronger participation of the patients to therapeutic décisions, underlines the patient educational interest, with concrete objectives of information, raising awareness and therapeutic education(1, 2). <h3>Objectives</h3> Specify the implication and the knowledge of french rheumatologists in the field of their patients éducation (PE) in osteoporosis. <h3>Methods</h3> Descriptive epidemiological survey by answer to a questionnaire, in June, 2011, with 99 rheumatologists, mean 44-year-old and practicing mainly at hospital (60%). <h3>Results</h3> The patients treated for osteoporosis are mainly between 50 and 75 years old (59%) and essentially women (83%). Few rheumatologists (17%) indicate having benefited from a specific patients educational formation. For rheumatologists, PE has to concern as well all the osteoporotics patients (90%) that their close relations (68%). For 70% of them, PE in osteoporosis is justified by a lack of knowledge about the disease, or about treatments of the disease. PE must be an integral part of any consultation (85%), but does not necessarily have to take place in a specific structured frame (61%). PE's objectives are multiple: therapeutic compliance (92%), fractures prevention (86%), physical activity (85%), information about osteoporosis (85%). 75% of the rhumatologists practise PE individually, by informing their patients orally (99%), or by giving them written supports (69%). They show particular interest in estimating the arrangement of patients residence when patients are isolated (73%), confiding this evaluation mainly to the families (80%). Among the limits to PE, they appoint the lack of time they can dedicate in their patients (56%), as well as the distrust of the patients to treatments (53%). Practitioners consider very important benefits brought by the PE on therapeutic compliance (77 mm on a 100 mm VAS), on doctor-patient relationship (75 mm), on prevention of falls (73 mm). <h3>Conclusions</h3> For 98% of the rheumatologists, the objectives of PE are the apprenticeship of a correct food intake, the information of patients about the disease, and the therapeutic compliance. An essential objective is to give responsibilities the patients towards the fracture's risk (97%) and to involve them more in its prévention strategies. To improve compliance, rheumatologists insist on the quality of the communication in the doctor – patient relationship, as well as on the conviction of the patient of the interest of the treatment. <h3>References</h3> HAS. Patient education. Recommendations, june 2007 (french) Law n° 2009-879, July 21, 2009 carrying reform of hospital and relative to the patients, to the health and to the territories ("HPST" law). (french) <h3>Disclosure of Interest</h3> R.-L. Dreiser Grant/Research support from: Expanscience Labs, M. Guilaume: None Declared