tbuckley/cabot-search huggingface dataset:
Abstract P2-05-19: Pathway-based analysis of breast cancer
Authors: D Song, M Cui, Z Fan, Y Yang, L Xue, DY Zhang, F Ye
Journal: Cancer Research (2012)

Abstract Objective: Although HER2 and ER pathways are predominant pathways altered in breast cancer, it is now well accepted that many other signaling pathways are also involved in the pathogenesis of breast cancer, especially in triple negative breast cancer. The understanding of these additional pathways may assist in identifying new therapeutic approaches for breast cancer. Methods: 13 invasive ductal carcinoma tissues and 5 benign breast tissues were analyzed for the mRNA expression level of 1243 cancer pathway-related genes using SmartChip (WaferGen, CA), a real-time PCR-base method. In addition, the levels of 154 cancer pathway-related proteins and phosphoproteins were measured using our innovative Protein Pathway Array. Results: Out of 1,243 mRNAs, 68.7% were detected in breast cancer and 73 mRNAs were statistically significant between benign and cancer tissues. Of these mRNAs, 105 only expressed in breast cancer tissues and 33 mRNAs only expressed in normal breast tissues. Out of 154 proteins and phosphoproteins, 39% were detected in cancer tissues and 50 proteins were significantly differentiated between tumor and normal tissues. Interestingly, only 3 genes (CDK6, Vimentin and SLUG) showed decrease of both protein and mRNA. Six proteins (BCL6, CCNE1, PCNA, PDK1, SRC and XIAP) showed differentially expressed between tumor and normal tissues but no differences were observed at mRNA levels. Analyses of mRNA and protein data using Ingenuity Pathway Analysis showed more 15 pathways were altered in breast cancers and 6 of them shared between mRNAs and proteins, including p53, IL17, HGF, NGF, PTEN and PI3K/AKT. Conclusion: There is a broad dysregulation of various pathways in breast cancer both at protein levels and mRNA levels. It is important to note that mRNA expression does not correlate with protein level, suggesting that different regulation mechanisms between proteins and mRNAs. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-05-19.
US abortion doctor shot dead
Authors: J. Ciment
Journal: BMJ (1998)

The murder last week of Dr Barnett Slepian, a New York obstetrician who had performed abortions as part of his work as a gynaecologist and obstetrician, has triggered a continent-wide investigation by police.

Dr Slepian, aged 51, was shot through his kitchen window last Friday night in front of several family members by a terrorist thought to be a Canadian man known to police as “the Remembrance Day sniper.” Remembrance Day (the Sunday nearest to 11 November, when services are held to commemorate the servicemen and servicewomen who died in …
IMPACT OF LEFT VENTRICULAR DIASTOLIC FUNCTION ON LONG-TERM MORTALITY IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Authors: Jae-Yeong Cho, Kye Hun Kim, Youngkeun Ahn, Sang Eun Lee, Hyun-Jai Cho, Hae-Young Lee, Jin-Oh Choi, Eun-Seok Jeon, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Shung Chul Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Hyun-Young Park, Myeong-Chan Cho, Byung-Hee Oh
Journal: Journal of the American College of Cardiology (2016)
The Fracture Blister
Authors: William R. Buckley, Walter C. Lobitz
Journal: New England Journal of Medicine (1953)

THERE is no mention in the dermatologic literature of the occurrence of vesicles or bullae (Fig. 1) secondary to fractures, and localized to the site of injury. The fracture blister may be noted before application, or after bivalving of a plaster cast. The lesion is usually produced by direct trauma. It is always associated with severe soft-tissue injury and an embarrassed circulation at the fracture site. Certainly, all orthopedists, general surgeons and general practitioners are familiar with the lesion from the clinical point of view because trauma and its care are distinctly in their province. Bullae, occurring as an epiphenomenon, . . .
Abstract SY06-01: Targeting IAP proteins for the treatment of cancer.
Authors: Domagoj Vucic
Journal: Cancer Research (2013)

Abstract Evasion of cell death is a characteristic feature of human cancers and represents a key cause of resistance to current treatment approaches. Therefore, reactivation of cell death programs in cancer cells is a promising strategy to overcome treatment resistance, one of the major unsolved problems in clinical oncology. Inhibitor of apoptosis (IAP) protein family members block cell death in response to diverse stimuli and are expressed at elevated levels in the majority of human malignancies, which makes them attractive targets for developing a novel class of cancer therapeutics. We have designed small-molecule IAP antagonists (smac mimetics) that bind with high affinities to select baculovirus IAP repeat (BIR) domains of IAPs resulting in a dramatic induction of c IAP auto-ubiquitination activity and rapid proteasomal degradation. IAP antagonists inhibit tumor growth in vivo as single agents and in combination with a number of anti-tumor agents. Using several different proteomic approaches we have discovered novel binding partners for IAP proteins and determined the spatial and temporal pattern of endogenous IAP-mediated ubiquitination during proliferative, apoptotic and necrotic signaling. The differential expression levels and posttranslational modifications of identified proteins will be used to build diagnostic profiles for the treatment with IAP antagonists. These compounds can be used in the treatment of malignancies in which IAP expression contributes to tumor progression and resistance to conventional chemotherapeutic agents. Citation Format: Domagoj Vucic. Targeting IAP proteins for the treatment of cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr SY06-01. doi:10.1158/1538-7445.AM2013-SY06-01
Case 4-2008
Authors: Lawrence N. Shulman, Rachel A. Hitt, Judith A. Ferry
Journal: New England Journal of Medicine (2008)

A 33-year-old pregnant woman was admitted to the hospital at 30.7 weeks' gestation because of swelling of the left breast, shortness of breath, and tachycardia. The swelling of the left breast had developed at 26.1 weeks' gestation and did not improve with antibiotic treatment. Ultrasonography and mammography showed enlargement of the left breast with increased density and no masses. A biopsy was performed. Shortness of breath developed, and the patient was admitted to the hospital. Computed tomography of the chest disclosed a large mediastinal mass.
Krysztof Krawczyński and Elżbieta Gürtler-Krawczyńska
Authors: Ned Stafford
Journal: BMJ (2016)

Krysztof Krawczynski , viral hepatitis expert, and his wife,  Elzbieta Gurtler-Krawczynska , cardiologist and radiologist, died in a car crash after a birthday outing
Abstract 3910: Lead optimization of a series of 5-aminopyrazol-imidazopyridine compounds as potent anaplastic lymphoma kinase inhibitors active against clinically relevant ALK mutations
Authors: Bin Yang, Jamal C. Saeh, Bo Peng, Victor Kamhi, Rane Harrison, Reema Harish, Allan Wu, David Whitston, Haiyun Wang, Minwei Ye, Suping Wang, Erin Code, Caroline Rivard, Lisa Drew, Anne Marie Mazzola, Daniel J. Russell
Journal: Cancer Research (2012)

Abstract Despite the success of Crizotinib in treating NSCLC patients with EML4-ALK fusions, cancers eventually develop resistance via a variety of mechanisms including mutations in the ATP binding site of the kinase domain. A series of 5-aminopyrazol-imidazopyridine compounds were identified to potently inhibit anaplastic lymphoma kinase and were found to be active against a number of mutations in vitro but suffered from strong Cyp inhibition and were found to be metabolically unstable by incubation in human hepatocytes and microsomes. Installation of a pyrimary alcohol group on the heteroaryl ethyl group of the scaffold consistently improved Cyp3A4 liability, and led to improvement in physical and DMPK properties as well as improvement of their metabolic stability in human Heps. The lead compound from this series was orally administrated to SCID mice in a Del xenograft model and achieved greater than 90% phospho-ALK inhibition over 6 hours post dose at 10 mg/kg dose. The lead compound was subsequently tested against Crizotinib-resistant ALK mutations in enzyme assays, and was shown to inhibit the clinically relevant ALK mutations, including L1196M. In enzyme assays, it was inactive against G1269S mutation, consistent with modeling studies. Subsequent profiling in an FDCP cell line over expressing ALK G1269S mutation showed potent anti-proliferative activity, suggesting off-target activity. Further characterization of this series identified AurB inhibition to be a key cell cycle kinase responsible for the off-target activity in the engineered cell line. The off target activity hinders it from assessing the primary pharmacology responsible for its preclinical efficacy in disease relevant models. In conclusion, we have identified a novel orally bioavailable compound that is a potent dual active ALK and AurB inhibitor that is active against clinically-relevant gatekeeper mutant. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3910. doi:1538-7445.AM2012-3910
AN “ALL-COMER” MINIMALIST APPROACH TO TRANSCATHETER AORTIC VALVE REPLACEMENT IS AS SAFE AND EFFECTIVE AS THE TRADITIONAL APPROACH
Authors: Gilbert Tang, Cheng Feng, Hasan Ahmad, Martin Cohen, Pascale Nadeau, Cenap Undemir, Angelica Poniros, Alexis Kearns, Ryan Kaple, Joanne Bennett, Amar Shah, Tanya Dutta, Steven Lansman
Journal: Journal of the American College of Cardiology (2016)
Gene Transfer Trial Approved
Authors: F. Antoine, E. Blume
Journal: JNCI Journal of the National Cancer Institute (1989)

Gene Transfer Trial Approved Get access Florenc Antoine, Florenc Antoine Search for other works by this author on: Oxford Academic PubMed Google Scholar Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 4, 15 February 1989, Pages 257–258, https://doi.org/10.1093/jnci/81.4.257 Published: 15 February 1989
Self-induced Hypoxia To Mimic the Clinical Symptoms of Reflex Sympathetic Dystrophy
Authors: Ivan Huyghe, Laurens Carp, Bondt Pieter De, Marc Driessens, Pierre Blockx
Journal: Clinical Nuclear Medicine (2002)

HUYGHE, IVAN M.D.,*; CARP, LAURENS M.D.,*; DE BONDT, PIETER M.D.,*; DRIESSENS, MARC M.D., Ph.D.† AND; BLOCKX, PIERRE M.D.* Author Information
Book: Moral Panics
Authors: A M Daniels
Journal: BMJ (1998)

Kenneth Thompson Routledge, £10.99, pp 176 ISBN 0415 119774 Rating: ![Graphic][1]</img>![Graphic][2]</img> The idea that morals, especially among the young, are deteriorating is not a new one: indeed, it is probably as old as civilisation itself. It either supposes that there was a golden age, when everyone behaved as he or she should, or is a straightforward misperception caused by advancing age. Kenneth Thompson, professor of sociology at the Open University, attempts in his short book both to describe and explain what have been called moral panics. He provides no … [1]: F1/embed/inline-graphic-1.gif [2]: F1/embed/inline-graphic-2.gif
Invasive Pulmonary Aspergillosis Associated with High-Dose Inhaled Fluticasone
Authors: Brett A. Leav, Barry Fanburg, Susan Hadley
Journal: New England Journal of Medicine (2000)

To the Editor: A 44-year-old man with moderately severe asthma was first seen in the infectious-disease clinic in November 1999 because of a recent diagnosis of pulmonary aspergillosis. The patient had noted an increase in his asthma symptoms during the summer of 1999. A chest x-ray film obtained at that time had revealed bilateral cavitary lesions. An open-lung biopsy in September 1999 had revealed chronic necrotizing aspergillosis. The patient had no known history of immunosuppression. His medications included fluticasone (delivered in two puffs of 220 μg four times a day [total daily dose, 1760 μg]) and zafirlukast (20 mg per . . .
863 CORRELATION OF IL28B POLYMORPHISM WITH DEGREE OF FIBROSIS: ANALYSIS OF TREATMENT-NAIVE AND TREATMENT-EXPERIENCED CAUCASIAN PATIENTS INFECTED WITH HCV GENOTYPE 1 IN THE GEN-C STUDY
Authors: A. Mangia, V. de L'edinghen, J. Keiss, J. Valantinas, J. Brahm, N. Rasmann, D. Messinger, F. Tatsch
Journal: Journal of Hepatology (2013)
P1147 OUTCOMES AND COSTS OF TREATING HEPATITIS C WITH PROTEASE INHIBITORS: RESULTS FROM A MULTI-CENTRE STUDY
Authors: J.T. Stahmeyer, S. Rossol, F. Bert, A.M. Abdelfattah, S. Mauss, R. Heyne, C. John, S. Pape, A. Schober, G. Teuber, H.R. Bruch, E. Zehnter, D. Hueppe, H. Pfeiffer-Vornkahl, U. Alshuth, C. Krauth
Journal: Journal of Hepatology (2014)
Researchers Flood USDA With Comments on Proposed Animal Welfare Regulations
Authors: S. Kumar
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Researchers Flood USDA With Comments on Proposed Animal Welfare Regulations Get access Seema Kumar Seema Kumar Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 17, 6 September 1989, Pages 1277–1278, https://doi.org/10.1093/jnci/81.17.1277 Published: 06 September 1989
Abstract 1598: Vasculogenic properties of triple negative breast carcinoma cells: possible implication for new molecular target
Authors: Elda Tagliabue, Ilaria Plantamura, Erica Dugnani, Cristina Ghirelli, Monica Tortoreto, Isabella Barajon, Francesca Arnaboldi, Roberto Agresti, Maria Luisa Carcangiu, Andrea Balsari, Marilena V. Iorio
Journal: Cancer Research (2010)

Abstract Triple negative (TN) breast cancers account for about 15-20% of breast cancers and are associated with aggressiveness, poor prognosis and shorter survival. Because of the lack of specific therapy guidelines for this subgroup there is an urgent need to define specific markers for therapeutic targeting in these tumors. We observed that TN breast cancer cells lines are able to perform “Vasculogenic Mimicry” (VM) in vitro. In fact, all four TN cell lines evaluated (MDA-MB-231, MDA-MB-157, MDA-MB-468 and HCC1937) were able to form vascular channels when seeded on the murine tumor-derived basement membrane (Matrigel), whereas luminal (MCF7 and ZR-75-1) and HER2-positive (MDA-MB-361 and SKBr3) breast carcinoma cell lines did not exhibit vascular structures. Then, we evaluated the VM in xenograft tumors derived from MDA-MB-231, MCF7 and MDA-MB-361 using transmission electron microscopy (TEM). In MDA-MB-231 xenografts it has been revealed channel-like structures formed by tumor cells encompassing erytrocytes, whereas in MCF7 and MDA-MB-361 xenografts the endothelial lining delimiting blood vessels was clearly visible. Notably, blood vessels surrounded by tumor cells were also identified in human TN specimens processed for TEM, and these structures were significantly more frequent in TN compared to non-TN tumors. 60% reduction in TN vascular channel formation in vitro by an anti-bFGF monoclonal antibody together with no effect using anti-VEGF antibody indicated that TN breast carcinoma cells can generate vascular channels through bFGF-mediated pathway. Silencing different receptors involved in bFGF signal (i.e. FGFR2 and PDFGR) abrogated VM in TN cells. Treatment of MDA-MB-231 xenografts with a TKI able to block both FGFR and PDGFR induced tumor regression, versus only slight growth inhibition in tumors derived from MCF7 luminal cell line. In conclusion our findings point to the possibility that TN tumors generate vascular channels independent of tumor angiogenesis and that targeting this VM capability may represent a valid therapeutic tool. (Partially supported by AIRC). Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1598.
Reliability of Visual and Quantitative Hepatobiliary Scintigraphy in the Follow-up of Patients Who Have Undergone Cholecystectomy and Transduodenal Sphincteroplasty
Authors: M Banci, M Ierardi, N S Tiberio, A Sita, M De Santis, E Rinaldi, G Boccabella, A M Mangano, S Tagliacozzo, F Scopinaro
Journal: Clinical Nuclear Medicine (1999)

A noninvasive scintigraphic technique to assess the efficacy of a surgical procedure (e.g., cholecystectomy and transduodenal sphincteroplasty) depends on the development of reliable and accurate qualitative or quantitative diagnostic criteria that allow early recognition of the occurrence and site of complications. For this purpose, the authors divided biliary flow into a four-step progression process and analyzed transit times from the peripheral vein to the gallbladder, common bile duct, and duodenum and the transit time from the common bile duct to the duodenum. These quantitative parameters were assessed in nine healthy volunteers and 31 asymptomatic patients who had previous cholecystectomy to validate their reliability. The results indicate that the four-step Tc-99m HIDA progression analysis provides a reliable, noninvasive evaluation of biliary flow, so that it can be applied to patients who have had cholecystectomy.
Abstract LB-368: The reduction of Bmi-1 expression increases the sensitivity of prostate cancer the cell line PC3 to X-ray irradiation
Authors: Gonzales C. Jason, Louis M. Fink
Journal: Cancer Research (2011)

Abstract Bmi-1 is a proto-oncogene that has been implicated in the polycomb complex that is required for cell proliferation and the maintenance of stem cells in a variety of tissues and cancers. Bmi-1 expression has been found to be elevated in a variety of tumors and its abundance has been correlated with survival. Previous studies have implicated Bmi-1 as having a role in radioresistance of cancer cells. In the present studies, we have shown that a stably integrated siRNA, which is conditionally regulated by doxycycline, can be used to study the susceptibility of prostate cancer cell line PC3 to radiation injury following a reduction of Bmi-1 expression. Human HEK293 cells were transfected with lentiviral packaging plasmids and the pTRIPZ vector containing an RFP reporter gene upstream of the Bmi-1 siRNA. PC3 cells were stably transduced with the Bmi-1 siRNA via lentivirus and were initially selected for the puromycin resistance. The RFP reporter gene and Bmi-1 siRNA is under control of a tetracycline response element (TRE) and, following the administration of doxycycline, RFP and Bmi-1 siRNA are concomitantly expressed. Studies on the expression of RFP, Bmi-1 RNA expression by RT-PCR and Bmi-1 measurements by western blots confirm the stable conditional expression of Bmi-1 in prostate cancer PC3 cells. The cell cycle analysis, the apoptotic rate and growth rates of the Bmi-1 expressing and non-expressing cell cultures were not significantly different. However, after treatment with 8 Gy x-irradiation, there was a marked increase in cells in the G2/M and in DNA fragmentation in the PC3 cells when Bmi-1 was reduced. There also was a marked decrease in the plating efficacy and in the cloning efficacy in methylcellulose. Perhaps the delineation of the Bmi-1 status of the cells in a biopsy or in the circulating tumor cells of patients with PC can be used to predict the biological behavior and therapeutic response of these cancers. This study was supported by grant DE-FG02–08ER64608 from the DOE. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-368. doi:10.1158/1538-7445.AM2011-LB-368
Increased 177Lu-DOTATATE Uptake in Paget Disease
Authors: Fabio Minutoli, Alessandro Sindoni, Davide Cardile, Giorgio Restifo Pecorella, Sergio Baldari
Journal: Clinical Nuclear Medicine (2013)

A 45-year-old female patient was referred for peptide receptor radionuclide therapy of liver metastases of neuroendocrine origin; the patient had undergone 2 years earlier surgical resection of a grade 2 neuroendocrine neoplasm of ampulla of Vater infiltrating the duodenal submucosa and muscular layers and the neighboring pancreatic tissue. Post-therapy whole-body scan performed to evaluate in vivo radiopharmaceutical distribution confirmed high accumulation in liver lesions and revealed increased uptake in the hip bone. Bone scan and corresponding CT images demonstrated changes of Paget disease in the same district.
An Outbreak of Diphtheria among Skid-Row Men
Authors: Clark W. Heath, Jack Zusman
Journal: New England Journal of Medicine (1962)

DURING the winter of 1961–1962 a small outbreak of diphtheria occurred among homeless men living in the skid-row section of Omaha, Nebraska. This outbreak is described here both as an example of diphtheria limited to adults and as an illustration of the problems that skid-row populations present for the effective public-health control of diphtheria in the United States.BackgroundThe skid-row section of downtown Omaha covers an area of about 20 blocks and consists largely of warehouses, bars and inexpensive rooming houses. The population of this area is made up almost entirely of homeless men, many of whom are destitute . . .
Case 31-1995
Authors: D.H. Lachance, D.N. Louis
Journal: New England Journal of Medicine (1995)

Presentation of CaseA 43-year-old man was admitted to the hospital because of increasing leg pain and bladder and bowel incontinence, with confusion.Sixteen years earlier the patient fell from a bicycle and began to have intermittent tingling of the left arm and leg. Five years before admission, while he was painting a porch, transient weakness developed on dorsiflexion of the left foot after prolonged squatting. The following month, pain developed in the left base of the neck, with intermittent tingling of the left hand and foot. A magnetic resonance imaging (MRI) examination of the cervical spine showed a moderate . . .
Using endoscopic ultrasound-guided fine needle aspiration to diagnose mediastinal cryptococcosis
Authors: E. Rahimi, D. Behin, A. Pellecchia
Journal: Endoscopy (2011)

A 33-year-old woman from Zimbabwe with AIDS and a CD4 count of 6 cells/mm3, non-compliant with antiretroviral therapy, presented with severe headaches, vomiting, fevers, and a productive cough. Physical examination revealed tachycardia, a temperature of 39.4 °C, clear lungs, and an absence of meningeal signs. Laboratory studies showed a white blood cell count of 4.8 and hemoglobin of 10.1 g/dL. A lumbar puncture was consistent with cryptococcal meningitis (cryptococcal antigen titer 1 : 32 768), and the patient had positive blood cultures growing Cryptococcus neoformans. The admitting chest radiograph was unremarkable.