tbuckley/cabot-search huggingface dataset:
Abstract 1798: The human mammary circadian transcriptome.
Authors: Joseph Combs, Tracy Mandichak, Elizabeth Ferree, Aaron E. Hoffman
Journal: Cancer Research (2013)

Abstract The circadian rhythm, a phenomenon present in all of Eukaryota and in some members of Prokaryota, describes the processes within an organism that fluctuate throughout a daily cycle. Within peripheral tissues, clock gene expression is organized into a roughly 24-hour period by an elaborate feedback loop mechanism developed around a core set of circadian genes. In addition to maintaining rhythmicity within the molecular clock, key circadian genes such as CLOCK and ARNTL1 are also transcription factors that regulate the expression of a number of additional transcripts; the so-called clock-controlled genes (CCGs). This transcriptional control forms the backbone of circadian rhythmicity and is critical for the maintenance of proper cellular function in a variety of physiological processes, ranging from cell cycle regulation to cellular metabolism. Despite the importance of this regulatory clockwork system, little is known about the extent of molecular circadian control in human peripheral tissues. In fact, the majority of our knowledge of molecular oscillatory systems is derived from studies of model organisms which consistently demonstrate that outside of the core circadian genes; there is virtually no overlap in the compendium of CCGs across tissue types. Based on this critical observation, it is reasonable to expect that if CCGs vary considerably across tissues within the same organism, there may also be considerable heterogeneity across organisms, even within the same tissue type. Here we use next-generation sequencing analyses to provide the first circadian transcriptome in pre-stasis non-immortalized primary human mammary epithelial tissue. Using the non-parametric JTK_CYCLE algorithm, we found that approximately 6% of all expressed genes within this tissue are CCGs. We also find considerable evidence for circadian control in RNA processing events, including splice isoform usage and alternative polyadenylation, and a pathway analysis of all CCGs indicates circadian involvement in multiple signaling and growth pathways. These results demonstrate, for the first time, that a significant and important proportion of the human mammary transcriptome is regulated by the circadian system. Given the importance of circadian disruption in the pathophysiology of a range of human disorders, from metabolic disease to breast cancer, we believe that categorization of the circadian rhythm in human peripheral tissue will lay an important foundation for future breakthroughs in disease prevention, as well as in the development of novel therapeutic strategies. Citation Format: Joseph Combs, Tracy Mandichak, Elizabeth Ferree, Aaron E. Hoffman. The human mammary circadian transcriptome. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1798. doi:10.1158/1538-7445.AM2013-1798
Valeur diagnostique de la biopsie guidée par echoendoscopie dans les syndromes lymphoprolifératifs: à propos d'une série de 59 cas
Authors: L Poincloux, M Andre, C Darcha, M Ruivard, O Tournilhac, A Abergel, M Dapoigny, G Bommelaer
Journal: Endoscopy (2011)

Introduction: Le but de cette étude était d'évaluer la sensibilité, la spécificité et la rentabilité diagnostique de la biopsie guidée par échoendoscopie (BG/EE) pour les syndromes lymphoprolifératifs à partir d'une série rétrospective réalisée dans un centre expert.
LEFT VENTRICULAR LONGITUDINAL FUNCTION IS CLOSELY RELATED TO VENTRICULAR ARRHYTHMIAS IN HYPERTROPHIC CARDIOMYOPATHY
Authors: Trine Haland, Vibeke Almaas, Jørg Saberniak, Ida S. Leren, Svend Aakhus, Thor Edvardsen, Kristina H. Haugaa
Journal: Journal of the American College of Cardiology (2015)
Normative and scientific approaches to the understanding and evaluation of art
Authors: Jonathan Gilmore
Journal: Behavioral and Brain Sciences (2013)

Abstract The psycho-historical framework proposes that appreciators' responses to art vary as a function of their sensitivity to its historical dimensions. However, the explanatory power of that framework is limited insofar as it assimilates relevantly different kinds of appreciation and insofar as it eschews a normative account of when a response succeeds in qualifying as an appreciation of art qua art.
AB0651 Preventive antituberculosis treatment before biologic agents initiating: frequency of prescription and tolerance in a sample of tunisian rheumatologic population
Authors: O. Saidane, L. Dridi, I. Mahmoud, H. Sahli, R. Tekaya, L. Abdelmoula, L. Chaabouni, R. Zouari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Treatment of latent tuberculosis (TB) is mandatory before biologic agents' instauration to prevent the risk of reactivation. <h3>Objectives</h3> To assess frequency and reasons of TB chemoprophylaxis prescription in rheumatologic population and its tolerance. <h3>Methods</h3> It is a retrospective monocentric study of medical records of patients receiving biologic agents (TNFalpha blockers and rituximab) who were hospitalized in Rheumatology department between 2005 and 2012. We included patients who received TB chemoprophylaxis. We noted epidemiologic characteristics, reasons of prescription, levels of alanine aminotransferase (ALAT) aspartate aminotransfere (ASAT,) prethrombin time (PT) and gamma-glutamyl transferase (GGT) before and during treatment and when any side effect was observed. <h3>Results</h3> Ninety tow prescriptions of biologic agents were reported in 84 patients. Among them, 11 (13%) received prophylaxis. Izoniazide 5mg/kg/day and Rifampicine 10mg/kg/day for 3 months (INH/RIF) were prescribed in all cases. Six patients presented with Rheumatoid arthritis (RA) and 5 with Spondylarthritis (SA). Age ranged from 34 to 76 with an average of 50 years. The mean disease duration was 10.3 years. The mean number of DMARDs previously received before introduction of biotherapy was 1.5 for patients with RA and 1 in patients with SA. The treatment by INH/RIF was prescribed in 11 cases because of intradermal tuberculin test positivity (n=8), an opacity on the chest radiography (n=1), QuantiFERON positivity (n=1) and because of positive culture of mycobacterium tuberculosis in urine (n=1) (in this case no urogenital TB was confirmed). Before INH/RIF instauration hepatic enzymes levels and TP were normal in all cases except one with hepatic steatosis (ALAT 2.7 times and GGT 4.2 times). Acetylating test was performed in all patients and INH dose was adapted based on. Biologic hepatotoxicity was noted in 3 cases. Cytolisis was noted in 1 case, increase of ALAT was 1.5 times and of ASAT 1,2 times. Cholestasis was seen in 2 cases, average increase of GGT of 1.5 times. No variation in TP level was noted. No of this 3 patients was receiving methotrexate or sulfasalazine. No changes in liver biologic tests was observed in the patient who had hepatic steatosis. Gastrointestinal side effects (nausea and abdominal pain) was seen in one case. No haematological, cataneous, neurological or ophthalmologic side effect was described. We did not need a therapeutic modification because the intensity of the side effects was mild. <h3>Conclusions</h3> Despite being a TB endemic country, prevalence of chemoprophylaxis prescription in Tunisian rheumatologic population is relatively low. Occurred side effects were always benign. <h3>Disclosure of Interest</h3> None Declared
Is Molecular Allergology Cost-Effective and Cost Saving in Children with Suspected Peanut Allergy Compared to Double Blind Placebo Controlled Food Challenge (DBPCFC) and Skin Prick Test in US, Europe and Asia?
Authors: Lisse-Lotte Hermansson, Barbara Mascialino, Susanne Glaumann, Magnus Borres, Gijs Hubben, Caroline Nilsson
Journal: Journal of Allergy and Clinical Immunology (2013)
Studies on the Pathogenesis of Alcohol-Induced Sideroblastic Bone-Marrow Abnormalities
Authors: John D. Hines, Dale H. Cowan
Journal: New England Journal of Medicine (1970)

Excessive amounts of alcohol were administered to three alcoholic volunteer subjects while all were on a nutritionally adequate diet except for folate content. In all three subjects folate deficiency, hypomagnesemia, hypokalemia and biochemical evidence of altered liver function developed. In vivo conversion of exogenously administered pyridoxine to pyridoxal phosphate was affected in all three. Hyperferremia, increased plasma radio-iron turnover with decreased erythrocyte iron utilization, dimorphic anemia associated with bone-marrow sideroblastic alterations and thrombocytopenia developed in two of the three subjects. Following treatment with parenteral pyridoxal phosphate the marrow sideroblastic abnormalities reverted to normal, and serum iron levels decreased markedly. Treatment with pharmacologic amounts of folic acid and pyridoxine had no such effect. In some alcoholic patients administration of alcohol seems to produce bone-marrow sideroblastic changes secondary to its effect on vitamin B6 metabolism.
Congenital Generalized Fibromatosis
Authors: JOHN R. STY, MARIO E. RUIZ, TIMOTHY J. CARMODY
Journal: Clinical Nuclear Medicine (1996)

Congenital generalized fibromatosis is an uncommon condition that most commonly affects the male newborn or young infant. There is widespread osseous lytic lesions. These lesions most commonly involve metaphyseal regions of long bones and may be expanded with or without a sclerotic margin. There can be involvement of the skin, muscles, viscera, and subcutaneous tissue. Single or multiple bone lesions and soft-tissue tumors may occur in the infant, and this entity is second only to angiomatous lesions as the most common neoplasms in this age group. The authors illustrate a case of congenital generalized fibromatosis in an infant with hepatic involvement demonstrated on a radionuclide bone scan. A computed tomographic study demonstrates the lesion, which was confirmed with biopsy.
Increased FDG Uptake of Heterotopic Pancreatitis in the Stomach
Authors: Aisheng Dong, Yang Wang, Hui Dong, Changjing Zuo
Journal: Clinical Nuclear Medicine (2013)

Heterotopic pancreas is the presence of pancreatic tissue lying outside of its normal location and lacking anatomic or vascular connections with the pancreas. Heterotopic pancreas can undergo inflammatory changes similar to the normal pancreatic gland. We present 2 rare cases showing increased 18F-FDG uptake in the heterotopic pancreatitis of the stomachs. To our knowledge, heterotopic pancreatitis with increased tracer accumulation on FDG PET/CT has not been reported before. Heterotopic pancreas should be included in the differential diagnosis of abnormal gastric FDG accumulation along with tumor and infectious processes.
A Prospective Study of the Risk of Tuberculosis among Intravenous Drug Users with Human Immunodeficiency Virus Infection
Authors: Peter A. Selwyn, Diana Hartel, Victor A. Lewis, Ellie E. Schoenbaum, Sten H. Vermund, Robert S. Klein, Angela T. Walker, Gerald H. Friedland
Journal: New England Journal of Medicine (1989)

To determine the risk of active tuberculosis associated with human immunodeficiency virus (HIV) infection, we prospectively studied 520 intravenous drug users enrolled in a methadone-maintenance program. Tuberculin skin testing and testing for HIV antibody were performed in all subjects. Forty-nine of 217 HIV-seropositive subjects (23 percent) and 62 of 303 HIV-seronegative subjects (20 percent) had a positive response to skin testing with purified protein derivative (PPD) tuberculin before entry into the study. The rates of conversion from a negative to a positive PPD test were similar for seropositive subjects (15 of 131; 11 percent) and seronegative subjects (26 of 202; 13 percent) who were retested during the follow-up period (mean, 22 months). Active tuberculosis developed in eight of the HIV-seropositive subjects (4 percent) and none of the seronegative subjects during the study period (P<0.002). Seven of the eight cases of tuberculosis occurred in HIV-seropositive subjects with a prior positive PPD test (7.9 cases per 100 person-years, as compared with 0.3 case per 100 person-years among seropositive subjects without a prior positive PPD test; rate ratio, 24.0; P<0.0001). We conclude that, although the prevalence and incidence of tuberculous infection were similar for both HIV-seropositive and HIV-seronegative intravenous drug users, the risk of active tuberculosis was elevated only for seropositive subjects. These data also suggest that in HIV-infected persons tuberculosis most often results from the reactivation of latent tuberculous infection; our results lend support to recommendations for the aggressive use of chemoprophylaxis against tuberculosis in patients with HIV infection and a positive PPD test. (N Engl J Med 1989; 320:545–50.)
Endoscopic ultrasound-guided ethanol ablation of pancreatic remnant following complicated total pancreatectomy
Authors: L. Barresi, A. Granata, I. Tarantino, G. Curcio, N. Azzopardi, C. Ricotta, V. Carollo, G. Marrone, A. Luca, M. Spada, M. Traina
Journal: Endoscopy (2013)

Endoscopic ultrasound (EUS)-guided ethanol ablation of pancreatic tissue has been documented in pigs [1] [2] and in humans in pancreatic insulinomas [3] [4] and in pancreatic cysts [5]. No data are available on the effect of ethanol injection into normal human pancreas, including accidental injection during treatment of pancreatic lesions.
THU0243 Proper Initiation of Biologic Treatment (TREAT-TO-TARGET STRATEGY) Favors Better Outcome in Patients with Rheumatoid Arthritis
Authors: C.E. Lampropoulos, F. Orfanos, V.-K. Bournia, T. Karatsourakis, K. Mavragani, D. Pikazis, M. Manousakis, A. Tzioufas, H.M. Moutsopoulos, P.G. Vlachoyiannopoulos
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune disease with involvement of small and large joints. Biologic agents (BAs) represent treatment options if disease is not adequately controlled by DMARDs. Treat-to-target strategy aims to improve the outcome of patients with RA and rapidly reduce disease activity by using properly and aggressively all the therapeutic options. <h3>Objectives</h3> To estimate the efficacy of proper initiation of BAs, according to EULAR therapeutic algorithm, in patients with RA compared to patients with delayed initiation of biologic treatment. <h3>Methods</h3> This is a retrospective study of 1.494 patients9 files (1.173 women and 321 men, mean age at disease initiation 48.9 years). Demographic and clinical data were recorded during every patient9s visit. There were 355 patients with initiation of biologic treatment during their follow-up in our department. Disease activity was classified by DAS-28 score at 3, 12 months and at the end of treatment with the first BA. Effectiveness of first BA was analyzed, taken in to account the EULAR criteria for response to treatment. <h3>Results</h3> There were 105 patients with proper and 250 patients with delayed initiation of BAs. In the first group, mean duration of BA administration was 30.8 months while DAS-28 before treatment was 4.83 and after treatment 2.55. In the second group mean duration of BAs was 51.0 months with DAS-28 before and after treatment 5.08 and 3.21 respectively. After 3 months of treatment, 59/100 (59%) patients with proper induction of BA achieved remission or low disease activity compared to 100/239 (41.8%) patients with delayed use (p=0.004). After 12 months of treatment, 52/66 (78.8%) and 111/181 (61.3%) patients from two groups respectively achieved remission or low disease activity (p=0.01). At the end of first biologic treatment, 50/105 (47.6%) patients, with proper induction of BAs, had remission, 27/105 (25.7%) low disease activity, 12/105 (11.4%) medial and 16/105 (15.2%) high disease activity. In contrary, 78/250 (31.2%) patients with delayed use achieved remission, 48/250 (19.2%) low, 56/250 (22.4%) medial and 68/250 (27.2%) high disease activity. Comparison between the two groups revealed a statistically significant advantage of proper initiation of BAs, as it concerns remission and/or low disease activity (p=0.001). <h3>Conclusions</h3> Treat-to-target treatment, according to EULAR therapeutic algorithm for BAs administration, offers a rapid and better long-term outcome to patients with RA. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4688
AB0685 Results for 6 minute walk values in healthy german children show similar results as from britain.
Authors: I. Foeldvari, G. Himmelmann
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> 6 minute walk is a primary outcome measure in therapeutic studies for patients with pulmonary hypertension. Currently we have a two of sets of data[1, 2] regarding test results in the 6 minute walk test (6MWT) in healthy children with a large span in the norm values in the different age groups. <h3>Objectives</h3> Aim of the study was to establish norm values for healthy German children for the 6 Minute Walk Test. <h3>Methods</h3> The team of an occupational therapist and a study nurse were visiting schools. Permission from the parents was give before the test. Always just probands from one class were invited to participate. The test were performed according the international guidelines[3]. The demographic data of the probands were collected and the parents filled out a short survey regarding the physical activity and the health condition. Children with chronic diseases, which decrease the stamina were excluded. <h3>Results</h3> Up till now 611probands participated from the age 5 ot 14 years. 343 of the 611 were female. The mean 6 minute walk continuously increased with age (Table 1.). It correlated in the age groups with the BMI. <h3>Conclusions</h3> Our results are in the range of the patients from the UK published by Lammers et al <sup>1</sup> and are in significantly lower range than in the Chinese population collected data by Li et al.<sup>2</sup>. This reflects the importance of this study to gain norm values for our patient population. <h3>References</h3> Li, A.M., et al., <i>Standard reference for the six-minute-walk test in healthy children aged 7 to 16 years.</i> Am J Respir Crit Care Med, 2007. <b>176</b>(2): p. 174-80. Lammers, A.E., et al., <i>The 6-minute walk test: normal values for children of 4-11 years of age.</i> Arch Dis Child, 2008. <b>93</b>(6): p. 464-8. Society, A.T., <i>ATS statement: guidelines for the six-minute walk test.</i> Am J Respir Crit Care Med, 2002. <b>166</b>(1): p. 111-7. <h3>Disclosure of Interest</h3> None Declared
AB0591 Influence of hand osteoarthritis on the magnitude of knee synovial effusion and hypertrophy in patients with knee osteoarthritis
Authors: C. Orellana, N. Navarro, J. Calvet, A. Gómez, J. Gratacós, M. Larrosa
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> A significant proportion of patients with knee osteoarthritis (OA) show local features of inflammation such as synovial effusion and synovial hypertrophy. On the other hand, in recent years it has been recognized the existence of a link between hand OA and systemic inflammation. <h3>Objectives</h3> To evaluate the possible influence of the presence of comorbid OA on the inflammatory features of knee OA measured by ultrasound (US). <h3>Methods</h3> METHODS: Cross-sectional study including consecutive patients aged 50 years or more with symptomatic OA of the knee and joint effusion, moderate radiographic OA (Kellgren-Lawrence II-III). Demographics, BMI, disease duration, pain assessed by VAS (0-100 mm) and algofunctional Lesquesne index were assessed. Knee ultrasound was performed evaluating and measuring the presence of effusion and synovial hypertrophy at the suprapatellar midline. <h3>Results</h3> We have analyzed 50 patients, F/M 39/11, age 61.8 ±10.1 years, disease duration 44.6 ±44.7 months, BMI 31.4 ±5.1 kg/cm2. Ten patients (20%) had concomitant hand OA. There were no significant differences in age, disease duration, BMI or radiological grade between patients with knee and hand OA compared with those with only knee OA. On ultrasound examination patients with concomitant hand osteoarthritis showed a trend to have a more prominent joint effusion (7.4 ± 3 vs. 7.1 ±2.3 mm) and synovial hypertrophy (3.6 ± 2.6 vs. 2.8 ±2.5 mm), although not statistically differences were found. Patients with concomitant hand OA also had a non-significant trend to experience greater knee pain (VAS 70.3 ±12.5 vs. 60.3 ±18.1 mm) and Lesquesne index scores (11.5 ±3.3 vs. 9.8 ±2.9). <h3>Conclusions</h3> The results from this study suggest that the coexistence of hand OA appears to be associated with more prominent inflammatory features in patients with knee OA and synovial effusion, although results were not statistically significant probably in relation to small size sample. <h3>Disclosure of Interest</h3> None Declared
A1
Authors: E G DePuey, L L Leatherman, W E Dear, R D Leachman, E K Massin, V S Mathur, J A Burdine
Journal: Clinical Nuclear Medicine (1984)

DePuey, E G; Leatherman, L L; Dear, W E; Leachman, R D; Massin, E K; Mathur, V S; Burdine, J A Author Information
Targeting adaptive glioblastoma: an overview of proliferation and invasion
Authors: Q. Xie, S. Mittal, M. E. Berens
Journal: Neuro-Oncology (2014)

Glioblastoma is one of the most devastating cancers, in which tumor cell infiltration into surrounding normal brain tissue confounds clinical management. This review describes basic and translational research into glioma proliferation and invasion, in particular the phenotypic switch underlying a stochastic "go or grow" model of tumor cell behavior. We include recent progress in system genomics, cancer stem cell theory, and tumor–microenvironment interaction, from which novel therapeutic strategies may emerge for managing this malignant disease. We suggest that an effective therapeutic strategy should target both adaptive glioblastoma cells and the stroma–tumor interaction.