tbuckley/cabot-search huggingface dataset:
Extracorporeal Shockwave Therapy Improves Functional Outcomes of Adhesive Capsulitis of the Shoulder in Patients With Diabetes
Authors: Flavia Santoboni, Stefano Balducci, Valeria D’Errico, Jonida Haxhi, Mario Vetrano, Giulia Piccinini, Andrea Ferretti, Giuseppe Pugliese, Maria Chiara Vulpiani
Journal: Diabetes Care (2016)

Adhesive capsulitis of the shoulder (ACS) is the most prevalent musculoskeletal disorder of the upper extremity (1,2) among people with diabetes. ACS is characterized by intense shoulder pain with progressive limitation of joint mobility and functional disability, negative impact on the quality of life, and increased health care costs (3). In the population without diabetes, treatment options include supervised physical therapy, oral or intra-articular steroid injections, extracorporeal shockwave therapy (ESWT), and arthroscopic capsular release (4). Oral or intra-articular steroids lead to rapid pain relief and improved range of motion (ROM), although benefits from steroids may not be maintained beyond 6 weeks in patients with diabetes (5). In addition, steroids can significantly increase glucose levels, thus affecting glycemic control in patients with diabetes. Therefore , it would be preferable to avoid steroids and opt for alternative therapies in these individuals. In …
Screening for ADAMTS13 Gene Mutations in Thrombotic Thrombocytopenic Purpura Reveals a New Deletional Mutation.
Authors: Teresa Fidalgo, Patricia Martinho, Ramon Salvado, Catarina Silva Pinto, Dalila Marques, Elsa Gonçalves, Natalia Martins, Maria Leticia Ribeiro
Journal: Blood (2008)
Microvesicle transfer of kinin B1-receptors is a novel inflammatory mechanism in vasculitis
Authors: Robin Kahn, Maria Mossberg, Anne-lie Ståhl, Karl Johansson, Ingrid Lopatko Lindman, Caroline Heijl, Mårten Segelmark, Matthias Mörgelin, L.M. Fredrik Leeb-Lundberg, Diana Karpman
Journal: Kidney International (2016)
Cytogenetic Analysis in Patients with Newly Diagnosed Myelodysplastic Syndromes in Southern Italy
Authors: Esther Natalie Oliva, Francesco Albano, Nicola Di Renzo, Vincenzo Pavone, Stefano Molica, Fortunato Morabito, Attilio Guarini, Giuseppe Tarantini, Silvana Capalbo, Emilio Iannitto, Giovanni Quarta, Nicola Cascavilla, Pierfrancesco Tassone, Francesco Iuliano, Roberto Porciello, Paola Casieri, Carmelo Laganà, Francesco Nobile, Giorgina Specchia
Journal: Blood (2012)
Overexpression of Eukaryotic Initiation Factor 4E Induces Critical Transcription Factors Such As c-Myc in Multiple Myeloma Resulting in Enhanced Clonogenic Tumor Growth in Vitro and in Vivo.
Authors: Shirong Li, Jing Fu, Jordan M. Schecter, Caisheng Lu, Markus Mapara, Suzanne Lentzsch
Journal: Blood (2012)
Immunoregulatory Effects of Allogeneic Mixed Chimerism Induced by T-Cell Depleted, Nonmyeloablative Bone Marrow Transplantation on Chronic Inflammatory Arthritis and Autoimmunity Developed in Interleukin-1 Receptor Antagonist-Deficient Mice.
Authors: Seok-Goo Cho, Min-Chung Park, So-Youn Min, Young-Gyu Cho, Seok Lee, Mi-La Cho, Hong-Seok Chang, Jong-Wook Lee, Woo-Sung Min, Ho-Youn Kim, Chun-Choo Kim
Journal: Blood (2005)
Vital Signs: Trends in HIV Diagnoses, Risk Behaviors, and Prevention Among Persons Who Inject Drugs — United States
Authors: Cyprian Wejnert, Kristen L. Hess, H. Irene Hall, Michelle Van Handel, Demorah Hayes, Paul Fulton, Qian An, Linda J. Koenig, Joseph Prejean, Linda A. Valleroy
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Persons who inject drugs (PWID) are at increased risk for poor health outcomes and bloodborne infections, including human immunodeficiency virus (HIV), hepatitis C virus and hepatitis B virus infections. Although substantial progress has been made in reducing HIV infections among PWID, recent changes in drug use could challenge this success.CDC used National HIV Surveillance System data to analyze trends in HIV diagnoses. Further, National HIV Behavioral Surveillance interviews of PWID in 22 cities were analyzed to describe risk behaviors and use of prevention services among all PWID and among PWID who first injected drugs during the 5 years before their interview (new PWID).During 2008-2014, HIV diagnoses among PWID declined in urban and nonurban areas, but have leveled off in recent years. Among PWID in 22 cities, during 2005-2015, syringe sharing decreased by 34% among blacks/African Americans (blacks) and by 12% among Hispanics/Latinos (Hispanics), but remained unchanged among whites. The racial composition of new PWID changed during 2005-2015: the percentage who were black decreased from 38% to 19%, the percentage who were white increased from 38% to 54%, and the percentage who were Hispanic remained stable. Among new PWID interviewed in 2015, whites engaged in riskier injection behaviors than blacks.Decreases in HIV diagnoses among PWID indicate success in HIV prevention. However, emerging behavioral and demographic trends could reverse this success.Access to comprehensive prevention services is essential for all PWID. Syringe services programs reduce syringe sharing and can help PWID access prevention and treatment services for HIV and other bloodborne diseases, such as hepatitis C and hepatitis B.
Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans
Authors: Krishnaraj S. Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S. Khambata, Umme Siddique, Saima Khan, Sven Van Eijl, Lorna C. Gee, Jascharanpreet Bansal, Kavi Pitrola, Christopher Shaw, Fulvio D’Acquisto, Romain A. Colas, Federica Marelli-Berg, Jesmond Dalli, Amrita Ahluwalia
Journal: Journal of Clinical Investigation (2016)

BACKGROUND. Cardiovascular disease occurs at lower incidence in premenopausal females compared with age-matched males. This variation may be linked to sex differences in inflammation. We prospectively investigated whether inflammation and components of the inflammatory response are altered in females compared with males.
Peripheral T-Cell Lymphomas (PTCL) Treated With Or Without Upfront Autologous Stem Cell Transplantation: Results Of a Retrospective Single Center Analysis
Authors: Alice Di Rocco, Angelo Fama, Eleonora Russo, Giovanna Meloni, Paolo Paesano, Laura Cesini, Michela Ansuinelli, Saveria Capria, Maurizio Martelli, Robin Foá, MD
Journal: Blood (2013)
Development of a New Experimental Animal Model of Human Megakaryopoiesis Using Immunodeficient NOD/Shi-scid, IL-2Rγnull (NOG) Mice.
Authors: Yoshitaka Miyakawa, Takanori Nakamura, Hiroshi Yoshida, Asako Ikejima, Mamoru Ito4, Yasuyuki Ohnishi4, Yasuo Ikeda
Journal: Blood (2005)
Anticoagulant Management of Atrial Fibrillation In the United States: Findings From a Large National Database of Clinical Test Results (Quest Diagnostics Health Trends™ Report).
Authors: Jeffrey S. Dlott, Roberta George, Xiaohua Huang, Muneer Odeh, Harvey W. Kaufman, Elaine M. Hylek, Jack Ansell
Journal: Blood (2010)
Evaluation of Baseline Body-Weight Dosing of Yttrium 90 (90Y) Ibritumomab Tiuxetan (Zevalin®) Radioimmunotherapy in Patients with Relapsed or Refractory B-Cell Non-Hodgkin’s Lymphoma (NHL).
Authors: Gregory Wiseman, Peter Conti, Katie Vo, Russell J. Schilder, Paul Foster, Leo I. Gordon, Christos Emmanouilides, Dan Silverman, Thomas E. Witzig, Arturo Molina
Journal: Blood (2004)
Angiogenesis Assessed in Tissue Microarrays of Diagnostic Follicular Lymphoma Correlates with Outcome.
Authors: Andrew J. Clear, Abigail M. Lee, Kelly J. Morris, Maria Calaminici, Finlay Macdougall, Rodrigo Proto-Siqueira, Lindsey K. Goff, Thomas A. Lister, John G. Gribben
Journal: Blood (2007)
Pharmacogenomics Study of Biological Pathways Related to Bortezomib Activity in Myeloma.
Authors: George Mulligan, Barb Bryant, Steven Roels, Andrew Bolt, Yan Meng, Erik Koenig, Anthony Boral, Dixie-Lee Esseltine, Kenneth A. Anderson, Peter Leif Bergsagel, Pieter Sonneveld, Annemiek Broyl, Constantine Mitsiades, Wee-Joo Chng, Paul G. Richardson, William Trepicchio
Journal: Blood (2007)
17p Deletion Predicts for Inferior Overall Survival after Fludarabine - Based First Line Therapy in Chronic Lymphocytic Leukemia: First Analysis of Genetics in the CLL4 Trial of the GCLLSG.
Authors: Stephan Stilgenbauer, Alexander Kröber, Raymonde Busch, Barabara Eichhorst, Dirk Kienle, Dirk Winkler, Georg Hopfinger, Peter Lichter, Bertold Emmerich, Michael Hallek, Hartmut Döhner
Journal: Blood (2005)
Phase I Trial of Flavopiridol In Relapsed Myeloma: Brief Response In t(4;14) with Significant Neutropenia
Authors: Craig C. Hofmeister, Mindy A Bowers, Seungsoo Lee, Mitch A. Phelps, Don M Benson, Eric H. Kraut, William J Hicks, Deidre Deam, Amy J Johnson, Sherif Farag, Jeffrey A. Jones, John C. Byrd
Journal: Blood (2010)
Aberrant DNA Methylation in CML Is Associated with Disease Progression and Resistance to Imatinib Mesylate.
Authors: Jaroslav Jelinek, Vazganush Gharibyan, Yasuhiro Oki, Woonbok Chung, Lanlan Shen, Jorge E. Cortes, Hagop M. Kantarjian, Jean-Pierre J. Issa
Journal: Blood (2006)
Are neutrophilic dermatoses autoinflammatory disorders?
Authors: T.K. Satoh, M. Mellett, E. Contassot, L.E. French
Journal: British Journal of Dermatology (2016)

Neutrophils constitute essential players in inflammatory responses and are the first line of defence against harmful stimuli. However, dysregulation of neutrophil homeostasis can result in excessive inflammation and subsequent tissue damage. Neutrophilic dermatoses are a spectrum of inflammatory disorders characterized by skin lesions resulting from a neutrophil-rich inflammatory infiltrate in the absence of infection. The exact molecular pathophysiology of neutrophilic dermatoses has long been poorly understood. Interestingly, neutrophil-rich cutaneous inflammation is also a cardinal feature of several autoinflammatory diseases with skin involvement, the latter being caused by aberrant innate immune responses. Overactivation of the innate immune system leading to increased production of interleukin-1 family members and 'sterile' neutrophil-rich cutaneous inflammation are features of both inherited autoinflammatory syndromes with skin involvement and an increasing number of neutrophilic dermatoses. Therefore, we propose that autoinflammation may be a cause of neutrophilic dermatoses.
Genomic DNA Copy Number Alterations Present in AML Bone Marrow Samples with Normal Cytogenetics.
Authors: Matthew J. Walter, Rhonda E. Ries, Jon Armstrong, Brian O’Gara, James W. Vardiman, Michael A. Caligiuri, Clara D. Bloomfield, Graeme Hodgson, Joe W. Gray, Richard K. Wilson, Elaine R. Mardis, Timothy J. Ley
Journal: Blood (2004)
AT7519, a Novel Small Molecule Multi-Cyclin Dependent Kinase Inhibitor, Induces Apoptosis in Multiple Myeloma VIA GSK3β
Authors: Loredana Santo, Sonia Vallet, Teru Hideshima, Diana Cirstea, Samantha Pozzi, Nileshwari Vaghela, Hiroshi Ikeda, Yutaka Okawa, Gullu Gorgun, Giulia Perrone, Elisabetta Calabrese, Matthew S Squires, Marco Ladetto, Nikhil C. Munshi, Mario Boccadoro, Kenneth C. Anderson, Noopur Raje
Journal: Blood (2008)
Dasatinib (SPRYCEL®) in Children and Adolescents with Relapsed or Refractory Leukemia: Preliminary Results of the CA180018 Phase I/II Study from the ITCC Consortium.
Authors: Christian M. Zwaan, M.L. den Boer, H.B. Beverloo, V.H.J. van der Velden, J.M.A. Van Tornout, D. Derreumaux, A. Baruchel, C. Rizzari, P. Kearns, R. Pieters
Journal: Blood (2007)
High Musashi-2 Expression Is an Unfavorable Prognostic Factor in Adult B-Cell Acute Lymphoblastic Leukemia.
Authors: Qitian Mu, Yungui Wang, Bing Chen, Wenbin Qian, Haitao Meng, Hongyan Tong, Feifei Chen, Qiuling Ma, Wangmao Ni, Sai-Juan Chen, Jie Jin
Journal: Blood (2012)
Outcome of Patients (pts) with Chronic Myeloid Leukemia (CML) Treated with Tyrosine Kinase Inhibitors (TKI) Who Have a History of Prior Malignancies,
Authors: Paul B Koller, Hagop M Kantarjian, Charles Koller, Elias Jabbour, Susan O'Brien, Srdan Verstovsek, Gautam Borthakur, Zeev Estrov, Alfonso Quintas-Cardama, Jorge E Cortes
Journal: Blood (2011)
The Effects of Zoledronic Acid Dose and Infusion Rate on Pharmacokinetics (PK), Pharmacodynamics (PD), and Renal Function in Patients with Multiple Myeloma.
Authors: James R. Berenson, Pierre Major, Regina A. Swift, Robert Vescio, Christina Rivera, Sanela Bilic, Sonia Gauron, Jannick Denouel, Horst Schran
Journal: Blood (2005)
KD7150, a Novel Mercaptoketone-Based HDAC Inhibitor, Exerts Potent Anti-Multiple Myeloma Effects In Vitro and In Vivo by Induction of DNA Damage and Mitochondrial Signaling.
Authors: Rentian Feng, Huihui Ma, Christian A. Hassig, Joseph E. Payne, Nicholas D. Smith, Markus Y. Mapara, Jeffrey H. Hager, Suzanne Lentzsch
Journal: Blood (2007)
Appropriate Use of High-Sensitivity Cardiac Troponin Levels in Patients With Suspected Acute Myocardial Infarction
Authors: Kasper Glerup Lauridsen, Jesper Revsholm, Bo Løfgren
Journal: JAMA Cardiology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Balancing Proliferation, Differentiation, and Survival: Powerful Genetic and RNAi Technologies Reveal Essential microRNA Signaling for Leukemic Progenitor Cell Fitness
Authors: Sara E. Meyer, Emily Orr, Andrew M. Rogers, John G Doench, Bruce J. Aronow, Ashish Lal, Edwina McGlinn, H. Leighton Grimes
Journal: Blood (2015)
SGN-CD33A in Combination with Hypomethylating Agents Is Highly Efficacious in Preclinical Models of AML
Authors: May S.K. Sutherland, Changpu Yu, Christine O'Day, Steve Alley, Martha Anderson, Kim Emmerton, Weipeng Zeng, Megan M. O'Meara, Eric J. Feldman, Dana A. Kennedy, Maureen C. Ryan, Dennis Benjamin
Journal: Blood (2015)
Cytogenetic Analysis of Normal Human B Cells Following CpG Stimulation: Implications for Interpretation of CpG Induced CLL Metaphase Analysis
Authors: Xiaosheng Wu, Grzegorz S. Nowakowski, Stephanie A. Smoley, Bonnie A. Arendt, Mark A. Peterson, Daniel van Dyke, Neil E. Kay, Diane F. Jelinek
Journal: Blood (2008)
Splenic Marginal Zone Lymphoma Shows a Distinct Pattern of DNA Copy Number Aberrations That Correlates with Tumor Characteristics and Predicts Disease Outcome.
Authors: Jose A. Martinez-Climent, Cristina Robledo, Manuela Mollejo, Anton Parker, Juan L. Garcia, Carlos Panizo, Lorena Fontan, Vicente Fresquet, Ellen D. Remstein, Sara Mould, Ahmet Dogan, Mark Law, Isabel Marugan, Maria J. Terol, Esperanza Vizcarra, David Graham Oscier, Miguel A. Piris, Jose M. Hernandez-Rivas
Journal: Blood (2006)
Evaluation of the Impact of Non-Inherited Maternal Antigens on the Outcome of HLA Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation for Hematological Malignancies on Behalf of the ALWP of the EBMT and the CIBMTR
Authors: Julia Pingel, Camila J. Hernandez Frederick, Tao Wang, Emmanuelle Polge, Michael D Haagenson, Stephanie J. Lee, Mohamad Mohty, Arnon Nagler, Stephen R. Spellman, Alexander H. Schmidt, Jon J. van Rood
Journal: Blood (2015)
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs
Authors: Marcus A. F. Corat, Heinrich Schlums, Chuanfeng Wu, Jakob Theorell, Diego A. Espinoza, Stephanie E. Sellers, Danielle M. Townsley, Neal S. Young, Yenan T. Bryceson, Cynthia E. Dunbar, Thomas Winkler
Journal: Blood (2016)
Promoting Patient (pt) Adherence (PA) with Imatinib Treatment (IMRx) in Chronic Myeloid Leukemia (CML): Physicians (MD) Perceptions of Utility (Effectiveness [FX], Feasibility [FB], Cost [CO]) and Rankings of Clinical Applicability (CAPL) of 13 Adherence-Enhancing Strategies (AESs) - Results from the ADAGIO Study.
Authors: Marie-Anne van Lierde, Eric Strobbe, Larissa De Rop, Filipo Serra, MacDonald MacDonald, Stefaan Vancayzeele, Sabina De Geest, Laurie Letvak, Tara Albrecht, Ivo Abraham
Journal: Blood (2007)
First in Human Phase 1 Single Dose Escalation Studies of the E-Selectin Antagonist GMI-1271 Show a Favorable Safety, Pharmacokinetic, and Biomarker Profile
Authors: Sumana Devata, Suman L. Sood, Martina V Hemmer, Henry Flanner, William Kramer, Christine Nietubicz, Angela Hawley, Dana E Angelini, Daniel Durant Myers, Susan Blackburn, James Froehlich, Thomas W. Wakefield, John L. Magnani, Helen M. Thackray
Journal: Blood (2015)
Graft-Versus-Host Disease (GVHD) and Survival Outcomes after HLA-Haploidentical (Haplo) Bone Marrow Transplant (BMT) Compare Favorably with Matched Related Donor (MRD), and Matched Unrelated Donor (MUD) BMT Utilizing High-Dose Posttransplantation Cyclophosphamide (PTCy)
Authors: Shannon R. McCurdy, Christopher G. Kanakry, Yvette L. Kasamon, Javier Bolanos Meade, Hua-Ling Tsai, Margaret M. Showel, Jennifer A. Kanakry, Heather J. Symons, Gary L. Rosner, Ephraim J. Fuchs, Richard J. Jones, Leo Luznik
Journal: Blood (2014)
LURET study: A phase II study of vandetanib, RET inhibitor in patients with advanced RET fusion-positive NSCLC
Authors: Kiyotaka Yoh, Takashi Seto, Miyako Satouchi, Makoto Nishio, Noboru Yamamoto, Haruyasu Murakami, Naoyuki Nogami, Takeharu Yamanaka, Koichi Goto
Journal: Annals of Oncology (2015)
Autosomal genetic control of human gene expression does not differ across the sexes
Authors: Irfahan Kassam, Luke Lloyd-Jones, Alexander Holloway, Kerrin S. Small, Biao Zeng, Andrew Bakshi, Andres Metspalu, Greg Gibson, Tim D. Spector, Tonu Esko, Grant W. Montgomery, Joseph E. Powell, Jian Yang, Peter M. Visscher, Allan F. McRae
Journal: Genome biology (2016)

Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, and has largely been explored by examining the contribution of genotype-by-sex interactions to variation in gene expression. In this study, we use data from a mixture of pedigree and unrelated individuals with verified European ancestry to investigate the sex-specific genetic architecture of gene expression measured in whole blood across n=1048 males and n=1005 females by treating gene expression intensities in the sexes as two distinct traits and estimating the genetic correlation (r G) between them. These correlations measure the similarity of the combined additive genetic effects of all single-nucleotide polymorphisms across the autosomal chromosomes, and thus the level of common genetic control of gene expression across the sexes. Genetic correlations are estimated across the sexes for the expression levels of 12,528 autosomal gene expression probes using bivariate GREML, and tested for differences in autosomal genetic control of gene expression across the sexes. Overall, no deviation of the distribution of test statistics is observed from that expected under the null hypothesis of a common autosomal genetic architecture for gene expression across the sexes. These results suggest that males and females share the same common genetic control of gene expression.
CD38 Expression above 20% Predicts Disease Progression in Chronic Lymphocytic Leukemia and Is a Useful Prognostic Marker Where Cytogenetic and Molecular Markers Are Not Available
Authors: Sina Alipour, Heather Leitch, Linda M Vickars, Lynda M Foltz, Paul F Galbraith, Chantal S Leger, Khaled M Ramadan
Journal: Blood (2008)
Effects of CK2 Inhibition on Multiple Signaling Pathways in Myeloma Cells
Authors: Francesco Alessandro Piazza, Barbara Montini, Diletta Arcidiacono, Carmela Gurrieri, Sabrina Manni, Anna Colpo, Laura Quotti Tubi, Renato Zambello, Livio Trentin, Gianpietro Semenzato
Journal: Blood (2008)
Eleven million people are in line for HIV tests through routine NHS contact
Authors: Anne Gulland
Journal: BMJ (2016)

Anyone living in an area where there is a high or extremely high prevalence of HIV infection should be offered a test for the virus when they register with a general practice or have a blood test, new guidelines say. The joint guidelines, from the National Institute for Health and Care Excellence and Public Health England, characterise extremely high prevalence as five or more diagnosed infections per 1000 people aged 15-59 years.1 Currently 20 local authorities in England (18 of which are in London) meet this definition (box), with an estimated total population for this age group of 3.7 million. #### Local authorities in England with “extremely high” HIV prevalence ##### London
Levels of ambient air pollution according to mode of transport: a systematic review
Authors: Magda Cepeda, Josje Schoufour, Rosanne Freak-Poli, Chantal M Koolhaas, Klodian Dhana, Wichor M Bramer, Oscar H Franco
Journal: The Lancet Public Health (2016)

Controversy exists about the differences in air pollution exposure and inhalation dose between mode of transport. We aimed to review air pollution exposure and inhaled dose according to mode of transport and pollutant and their effect in terms of years of life expectancy (YLE).In this systematic review, we searched ten online databases from inception to April 13, 2016, without language or temporal restrictions, for cohort, cross-sectional, and experimental studies that compared exposure to carbon monoxide, black carbon, nitrogen dioxide, and fine and coarse particles in active commuters (pedestrian or cyclist) and commuters using motorised transport (car, motorcycle, bus, or massive motorised transport [MMT-ie, train, subway, or metro]). We excluded studies that measured air pollution exposure exclusively with biomarkers or on the basis of simulated data, reviews, comments, consensuses, editorials, guidelines, in-vitro studies, meta-analyses, ecological studies, and protocols. We extracted average exposure and commuting time per mode of transport and pollutant to calculate inhaled doses. We calculated exposure and inhaled dose ratios using active commuters as the reference and summarised them with medians and IQRs. We also calculated differences in YLE due to fine particle inhaled dose and physical activity.We identified 4037 studies, of which 39 were included in the systematic review. Overall, car commuters had higher exposure to all pollutants than did active commuters in 30 (71%) of 42 comparisons (median ratio 1·22 [IQR 0·90-1·76]), followed by those who commuted by bus in 57 (52%) of 109 (1·0 [0·79-1·41]), by motorcycle in 16 (50%) of 32 (0·99 [0·86-1·38]), by a car with controlled ventilation settings in 39 (45%) of 86 (0·95 [0·66-1·54]), and by MMT in 21 (38%) of 55 (0·67 [0·49-1·13]). Overall, active commuters had higher inhalation doses than did commuters using motorised transport (median ratio car with controlled ventilation settings 0·16 [0·10-0·28]; car 0·22 [0·15-0·30]; motorcycle 0·38 [0·26-0·78]; MMT 0·49 [0·34-0·81]; bus 0·72 [IQR 0·50-0·99]). Commuters using motorised transport lost up to 1 year in YLE more than did cyclists.Proximity to traffic and high air interchange increased the exposure to air pollution of commuters using motorised transport. Larger inhalation rates and commuting time increased inhaled dose among active commuters. Benefits of active commuting from physical activity are larger than the risk from an increased inhaled dose of fine particles.Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS), National Health and Medical Research Council, Nestlé Nutrition (Nestec), Metagenics, and AXA.