tbuckley/cabot-search huggingface dataset:
Distribution of AIDS Cases, by Racial/Ethnic Group and Exposure Category, United States, June 1, 1981-July 4,1988
Authors: R M Selik, K G Castro, M Pappaioanou
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0708 Clinical and Hepatic Histopathological Features in 13 Cases of Idiopathic Inflammatory Myopathy with Liver Damage
Authors: K. Furuya, K. Noda, T. Harada, K. Yoshida, D. Kurosaka
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Among patients with idiopathic inflammatory myopathy (IIM), not a few cases are associated with a variable degree of liver dysfunction<sup>1,2.</sup>. Not only aspartate aminotransferase (AST) as a myogenic enzyme, but also other hepatogenic enzymes, such as alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamyl transpeptidase (γ-GTP), can rise in serum of the patients. <h3>Objectives</h3> To investigate the clinical characteristics and hepatic histopathological findings in IIM. <h3>Methods</h3> We retrospectively extracted 13 adult patients who was diagnosed as IIM in our hospital and underwent liver biopsy during the period of 2007 to 2014. We evaluated the clinical, serum, and hepatic histopathological aspects. <h3>Results</h3> The case group comprised eight patients of polymyositis (PM) and five dermatomyositis (DMy). Mean age of the patients (three men and ten women) was 55.5 (24-76) years. The mean serum creatine kinase (CPK) level was 2352 (229-7515) IU/l, and the mean serum AST, ALT, ALP, and γ-GTP levels were 184.2 (42-857) IU/l, 142.3 (32-614) IU/l, 314.8 (114-601) IU/l, and 71.9 (15-250) IU/l, respectively. The histopathological findings in liver showed: two with autoimmune hepatitis (AIH) and two with primary biliary cirrhosis (PBC). All the four cases were polymyositis patients. In two out of five DMy, hepatocyte ballooning, ceroid-laden macrophage and acidophilic body were detected, but lymphocyte infiltration was very few. Another one of DMy was diagnosed non-alcoholic steatohepatitis (NASH) that also showed the hepatocyte ballooning. In addition, serum ferritin levels of these three cases were high (about 1373-1563 ng/ml) and CPK levels were relatively low (226-415 IU/l). Remaining six cases only showed non-specific mild liver damage. None of all 13 cases show normal liver histology. <h3>Conclusions</h3> This study suggested that liver inflammation occer with high frequency in IIM, but the property may differ between PM and DMy. <h3>References</h3> Matsumoto T, Kobayashi S, Shimizu H, Nakajima M, Watanabe S, Kitami N, et al. The liver in collagen diseases: pathologic study of 160 cases with particular reference to hepatic arteries, primary biliary cirrhosis, autoimmune hepatitis and nodular regenerative hyperplasia of the liver. Liver 2000; 20: 366-373 Takahashi A, Abe K, Yokokawa J, Iwadate H, Kobayashi H, Watanabe H, et al. Clinical features of liver dysfunction in collagen diseases. Hepatology Research 2010; 40: 1092-1097 <h3>Acknowledgements</h3> The authors grateful to staffs of department of rheumatology, hepatology, pathology of the Jikei University Hospital. <h3>Disclosure of Interest</h3> None declared
Definitive endoscopic pyloric exclusion with an over-the-scope clip
Authors: Rolando Pinho, Carlos Fernandes, Alexandre Costa, Luísa Proença, Sónia Fernandes, Jorge Carrapita, João Carvalho
Journal: Endoscopy (2015)

A 48-year-old man underwent primary surgical repair of an iatrogenic duodenal perforation, sustained during endoscopic ultrasonography. After 2 weeks, dehiscence of the suture with intra-abdominal infection and abscesses was identified, for which pyloric–duodenal dissociation with pyloric closure, duodenostomy, gastrojejunostomy, and multiple drainages were performed. Spontaneous opening of the sutured pylorus with leakage of contrast was observed 4 weeks later.
What’s in a Name?
Authors: Reshma Jagsi
Journal: JAMA (2013)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Effect of Serum Fractions on the Proliferation of Strain L Mouse Cells &lt;italic&gt;in Vitro&lt;/italic&gt;
Authors: K K SANFORD, B B WESTFALL, M C FIORAMONTI, W T MCQUILKIN, J C BRYANT, E V PEPPERS, V J EVANS, W R EARLE
Journal: JNCI Journal of the National Cancer Institute (1955)

The Effect of Serum Fractions on the Proliferation of Strain L Mouse Cells in Vitro Get access Katherine K. Sanford, Katherine K. Sanford Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Benton B. Westfall, Benton B. Westfall Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary C. Fioramonti, Mary C. Fioramonti Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar William T. McQuilkin, William T. McQuilkin Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jay C. Bryant, Jay C. Bryant Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellison V. Peppers, Ellison V. Peppers Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia J. Evans, Virginia J. Evans Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle Wilton R. Earle Laboratory of Biology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 3, December 1955, Pages 789–802, https://doi.org/10.1093/jnci/16.3.789 Published: 01 December 1955 Article history Received: 23 June 1955 Published: 01 December 1955
Temporary dumping syndrome after gastric peroral endoscopic myotomy: should we control the glycemia?
Authors: Typhaine Louazon, Jérome Rivory, Sabine Roman, François Mion, Thierry Ponchon, Mathieu Pioche
Journal: Endoscopy (2016)

Gastric peroral endoscopic myotomy (G-POEM) is a new endoscopic technique that involves cutting the pyloric sphincter, with minimal invasiveness compared with the surgical approach [1] [2] [3]. The technique can be used to treat post esophagectomy gastric outlet obstruction [4]. Here, we report the case of post esophagectomy outlet obstruction treated with G-POEM but complicated by multiple episodes of post-procedure hypoglycemia.
R-CHOP14 versus R-CHOP21: Result of a randomized phase III trial for the treatment of patients with newly diagnosed diffuse large B-cell non-Hodgkin lymphoma.
Authors: D. Cunningham, P. Smith, P. Mouncey, W. Qian, A. S. Jack, C. Pocock, K. Ardeshna, J. A. Radford, A. J. Davies, A. McMillan, M. D. Linch
Journal: Journal of Clinical Oncology (2011)

8000 Background: The addition of rituximab to standard therapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone (CHOP21) has resulted in improved survival outcomes in the treatment of diffuse large B-cell non-Hodgkin lymphoma (DLBC NHL). In addition, the administration of CHOP as a 14 day cycle (CHOP14) has shown benefit over standard CHOP21 chemotherapy. This randomised trial was designed to evaluate the improvement in overall survival of rituximab combined with CHOP given every 14 days (R-CHOP14), as compared to standard therapy (R-CHOP21) in newly diagnosed DLBC NHL. Methods: Patients were randomised to receive either eight cycles of standard R-CHOP21 or six cycles of R-CHOP14 (+ G-CSF) with two additional cycles of single agent rituximab. The primary outcome was overall survival (OS). A total of 233 deaths were required to detect a 7-8% difference in the OS with 5% significance level and 90% power. Results: Between March 2005 and November 2008, 1080 (540 in each arm) patients were recruited. Baseline patient characteristics were balanced between arms with a median age of 61 years old, 62% stage III/IV disease, 45% B symptoms, and 49% bulk disease. 82% of patients in the R-CHOP21 arm completed study therapy as compared to 89% in the R-CHOP14 arm. Reported grade III/IV toxicities in the R-CHOP21 and R-CHOP14 arms are; neutropenia 57%:31%, thrombocytopenia 5%:9%, Infection 22%:17%, cardiac 1%:2%, nausea and vomiting 8%:8%, mucositis 2%:3%. With a median follow-up 37 months, a total of 237 deaths and 318 progressions/relapses/deaths were observed. Comparison of Kaplan-Meier curves gave a hazard ratio (HR) of 0.96 and p=0.75 for OS and HR=1.0 and p=0.98 for progression-free survival (PFS) Conclusions: There is no evidence that R-CHOP14 improves patients OS or PFS comparing with the standard R-CHOP21.
Circulating microRNAs as potential blood-based biomarkers for detection of colorectal cancer
Authors: A. Chajut, S. Benjamin, S. Gilad, Y. Goren, H. Dan, O. Zion, M. Kushnir, Y. Kundel, Y. Niv, B. Brenner
Journal: Journal of Clinical Oncology (2009)

e15040 Background: Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. While there is a strong correlation between stage and prognosis in this disease, current screening methods for CRC have significant limitations, and newer technological approaches are desired. Circulating nucleic acids in body fluids have been studied as a source for diagnostic information and for cancer screening, yet the potential of microRNAs, a family of small non-coding regulatory RNAs, has not yet been thoroughly explored. Here we investigated the utility of microRNAs as potential serum biomarkers for early detection of CRC. Methods: We developed protocols for extracting and quantifying microRNA levels in serum. Serum levels of more than 350 microRNAs were measured using qRT-PCR on samples from 10 healthy controls and 10 CRC patients. Most microRNAs showed consistent levels across different individuals. A subset of microRNAs had significant differences in abundance between the two groups and was studied on a larger cohort of 118 patients and controls. Results: We initially identified a subset of microRNAs that showed significant differential abundance between sera of CRC patients and controls. Measuring the serum levels of 22 microRNAs on a cohort of 118 patients and controls, we showed that levels of circulating microRNAs can be very informative in the identification of CRC. Conclusions: The results demonstrate the potential of the microRNA processing and analysis methods that we developed. Certain microRNAs were found in different amounts in sera of CRC patients compared to healthy controls. Thus, circulating microRNAs represent promising candidates for diagnostic biomarkers in CRC. [Table: see text]
Communication of the Coronary Sinus with the Left Atrium
Authors: A L Sutton, D Miranda, B S Sherman, D E Rosenberg
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Turmoil in Medical Education: Peking, Paris, and Points West
Authors: E. J. H.
Journal: Annals of Internal Medicine (1969)

Editorials1 January 1969Turmoil in Medical Education: Peking, Paris, and Points WestE. J. H.E. J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-70-1-225 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBloody heads, greasy mops of hair, volleys of cobblestones, obscenities on classroom walls, sit-ins, and firebombs have made clear to the physician who has time to read his daily paper that students around the world are in turmoil. Yet this turbulent scene is not what some simple-minded observers believe it to be—a masterminded, cohesive army of anarchists. The disquiet and agitation of students is spurred by differing pressures and events in each site of upheaval. In Paris the target is an anachronistic system of education (1), staffed by rigid hierarchies, tightly held by central control, and packed into inadequate buildings....References1. SAMUELSON RJ: L'université est morte, vive l'université. Science 162: 240, 1968. CrossrefMedlineGoogle Scholar2. CiantarGuillermay MJ An interview []. Trying to comprehend the incomprehensible. Two experts explain China's cultural revolution. The New York Times Magazine, November 17 1968. Google Scholar3. CHANGYANGTU TTJ: How we have struggled against unstable diabetes mellitus in the light of Mao-Tse-Tung's thought. China's Medicine 7: 400, 1968. Google Scholar4. : Thoroughly criticize and repudiate the eight-year medical education program pushed by China's Krushchov. China's Medicine 3: 164, 1968. MedlineGoogle Scholar5. Livre blanc de la réforme. Semaine des Hopitaux Informations, p. 5 [supplément à La Semaine des Hopitaux, no. 29, June 14, 1968]. Google Scholar6. ANDERSON RH: Soviet physicians said to lack bedside manner. The New York Times, September 8 1968. Google Scholar7. SIMPSONMATTHEWS MAT: Report on Medical Education, 1968, British Medical Students' Association, British Medical Association House, London, 1968. Google Scholar8. Student participation (leading article). Brit-Med. J. 2: 693, 1968. Google Scholar9. COPPOLAGONNELLA EDJS: A nondirective approach to clinical instruction in medical school. JAMA 205: 487, 1968. CrossrefGoogle Scholar10. Principal Recommendations of the Workshop on Medical School Curriculum, Association of American Medical Colleges, November 4, 1968, Houston, Tex. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOn The Making and Use of PhysiciansJ. R. E. 1 January 1969Volume 70, Issue 1Page: 225-228KeywordsMedical education ePublished: 1 December 2008 Issue Published: 1 January 1969 PDF downloadLoading ...
Allowing the Debilitated to Die
Authors: David Hilfiker
Journal: New England Journal of Medicine (1983)

The phone wakes me; it is 3 a.m."Hello, Dr. Hilfiker? This is Ginger at the nursing home. Mrs. Toivonen has a fever."Despite my tiredness my mind is immediately clear. Elsa Toivonen, 83 years old. Confined to the nursing home ever since her stroke three years ago. Bedridden. Aphasic. In an instant I remember her as she was before the stroke: her dislike and distrust of doctors and hospitals, her staunch pride and independence despite her severe scoliosis, her wry grin every time I suggested hospitalization for some problem. I remember admitting her to the hospital after her stroke, . . .
PTU-055 Hyperamylasaemia and acute pancreatitis after double balloon enteroscopy: a prospective study: Abstract PTU-055 Table 1
Authors: MF Hale, DS Sanders, R Sidhu
Journal: Gut (2015)

<h3>Introduction</h3> Hyperamylasaemia and acute pancreatitis are potential complications following a double balloon enteroscopy (DBE) procedure. The mechanism of these complications is not fully understood. We present a prospective analysis of all patients undergoing DBE at a tertiary centre. <h3>Method</h3> Single centre, prospective study involving all consecutive patients attending for DBE by either route, between 23<sup>rd</sup>Aug 2012 and 3<sup>rd</sup>October 2014. Serum amylase levels were obtained before and three hours after the procedure. Clinical evaluation for signs and symptoms of pancreatitis was performed three hours after the procedure. A record of the procedure duration, insertion depth and number of passes was also documented. Hyperamylasaemia was defined as an elevation of the serum amylase level to greater than the upper limit of normal. <h3>Results</h3> 115 procedures were performed on 89 patients, mean age 57.4 years (21–83 years), 46 male (51.7%). Indication for procedure is presented in Table 1. 91 procedures were performed per orally and 24 via the anal route. 88 procedures were performed on the basis of a positive small bowel capsule endoscopy (SBCE), 9 patients did not have prior SBCE due to failure to excrete the patency capsule. Indication for DBE is presented in Table 1. Overall 47 patients (61%) had an elevated serum amylase post procedure. Hyperamylasaemia post-procedure was observed in significantly more patients following per-oral DBE compared to DBE via the anal route (p = 0.03). Hyperamylasaemia in the per-oral group was associated with procedure depth (mean 147 cm vs 187 cm p &lt; 0.0009) and number of passes (mean 10 vs 18 p &lt; 0.0007), but not procedure duration (mean 64 vs 70 mins p = 0.2) or dose of fentanyl administered (mean 108 mcg vs 118 mcg p = 0.6). No patients developed signs or symptoms of pancreatitis post-procedure. <h3>Conclusion</h3> Hyperamylasaemia is common following DBE per-orally and is associated with procedure depth and number of passes. However, in the majority of cases this is of limited clinical significance and no patients in our series went on to develop pancreatitis. <h3>Disclosure of interest</h3> None Declared.
Smoking and Alcoholism
Authors: Barry M. Maletzky, James Klotteb
Journal: American Journal of Psychiatry (1974)

The authors interviewed 57 hospitalized alcoholics and 50 nonhospitalized control subjects to clarify the relationship between alcoholism and cigarette smoking. They found that alcoholics smoked significantly more than nonalcoholics, even when only women subjects were considered. In addition, there was a high positive correlation between the amount alcoholics drank and the amount they smoked. However, when they were abstaining from alcohol consumption, alcoholic subjects did not necessarily smoke more. The authors discuss the implications of these findings both for treatment and for two theoretical models, oral "drive" and susceptibility.
Leukemoid Reactions to Transplanted Mouse Tumors
Authors: Bateman, Jeanne C.
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Leukemoid Reactions to Transplanted Mouse Tumors Get access Jeanne C. Bateman, M. D. Jeanne C. Bateman, M. D. Research Fellow Pathology Section, National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 4, February 1951, Pages 671–687, https://doi.org/10.1093/jnci/11.4.671 Published: 01 February 1951 Article history Received: 07 July 1950 Published: 01 February 1951