tbuckley/cabot-search huggingface dataset:
AB1230 Do serum zinc levels and oxidative status change in familial mediterranean fever patients during attack and attack free period?
Authors: S. Senel, K. Deveci, A.U. Uslu, A. Deniz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Familial Mediterranean fever(FMF) is a chronic autoinflammatory disease, and thus there may be an abnormality in the oxidative stress level of FMF patients. Zinc (Zn)is an anti-inflammatory agent and it plays an important role on oxidative stress. <h3>Objectives</h3> We aimed to determine Zn blood levels and oxidative stress status in patients with FMF and compare these characteristics with those in healthy controls. <h3>Methods</h3> Fifty patients with FMF during attack period (AP), 38 patients with FMF during attack free periods (AFP) and 30 healthy controls were enrolled to the study. Oxidative status included total antioxidant capacity (TAC), total oxidant status (TOS) and calculation of oxidative stress index (OSI) in sera of FMF patients and healthy controls. Serum Zn levels were measured spectrophotometrically. <h3>Results</h3> Levels of Zn (58.26±15.64 μg/dl and 68.78±13.58 μg/dl vs 95.20±17.61 μg/dl; p&lt;0.001) and TAC (1.22±0.24 and 1.17±0.21 vs 1.54±0.18; p&lt;0.001) were significantly lower in FMF-AP group and FMF-AFP group when compared with HC group, respectively. The Zn levels and TAC levels in FMF-AP group were also markedly lower (p&lt;0.001) when comparing FMF-AFP group. Levels of TOS (17.46±13.87 and 9.43±5.79 vs 3.34±1.18) and OSI (1.56±1.45 and 0.83±0.52 vs 0.21±0.08; p&lt;0.001) were significantly higher in serumof FMF-AP group and FMF-AFP group compared with HC group, respectively. The TOS levels and OSI values were also significantly higher (P&lt;0.001) in FMF-AP group than FMF-AFP group. For the FMF patient group, a significant positive correlation was observed between serum Zn levels and TAC (r =0.486, p&lt;0.001 and r =0.397, p&lt;0.001, respectively). <h3>Conclusions</h3> Our study demonstrated that Zn levels were decreased in serum and oxidative stress were increased during AP in patients with FMF. It is not known that these findings are primary results or secondary affects of attacks of FMF. <h3>Disclosure of Interest</h3> None Declared
THE EFFECTS OF PREDILATION WITH SCORING BALLOON COMPARED TO CONVENTIONAL BALLOON ON COBALT-CHROMIUM STENT EXPANSION ANALYZED WITH OPTICAL COHERENT TOMOGRAPHY
Authors: Kentaro Jujo, Ahsung Kim, Issei Ishida, Yuki Suzuki, Yuho Furuki, Gaku Nakazawa, Nobuhisa Hagiwara, Katsumi Saito
Journal: Journal of the American College of Cardiology (2015)
18F-FDG PET/CT Demonstrating Primary Bone Lymphoma of the Extremities Mimicking an Inflammatory Peripheral Arthropathy
Authors: Ayano Tachibana, Richard J Robinson, Chirag N Patel
Journal: Clinical Nuclear Medicine (2014)

A 66-year-old woman presents with progressive bilateral swelling of her fingers, elbows, and toes. Initially thought to represent an inflammatory peripheral arthropathy, the patient underwent rheumatology review, but subsequent tissue biopsy confirmed diffuse large B-cell lymphoma. Results of bone marrow biopsy and staging CT were negative. F-FDG PET/CT demonstrates FDG-avid bony and adjacent soft tissue disease limited to the extremities with an excellent metabolic response to primary chemotherapy. This is a rare case of primary bone lymphoma limited to the extremities mimicking an inflammatory peripheral arthropathy.
Abstract 595: E-3810 antitumor activity in human xenografts expressing different levels of FGF receptor 1
Authors: Gennaro Colella, Giovanna Damia, Maurizio D'Incalci, Roberta Cereda, Ingmar Peitz, Gerhard Kelter, Ennio Cavalletti, Silvano Spinelli, Gabriella Camboni
Journal: Cancer Research (2011)

Abstract E-3810 is a novel small molecule that selectively inhibits VEGF receptor-1, -2 and -3 and FGF receptor-1 (FGFR-1) tyrosine kinases currently undergoing a Phase 1 clinical trial in Europe. We have previously shown that the compound has strong anti-angiogenic effects in vivo and displays potent activity in all the human xenograft models in which it has been tested. We have also recently demonstrated that interference with FGF/FGFR pathway could result in a higher drug cytotoxic activity in those cell lines whose growth in vitro was dependent on the pathway. In order to corroborate these findings in an in vivo setting, a panel of human xenografts characterized by different expression of FGFR-1and FGF2 ligand is being screened for the response to E-3810 given at its optimal dose (20 mg/kg per os daily). Athymic female mice were transplanted s.c. with the different human xenografts and, when tumor masses reached the size of 80-120 mg, were randomized to receive vehicle or E-3810 for 14 days. Results are available for 7 models (see table reported below). All the selected tumors displayed similar growth rates, except for RXF_486 that grew more slowly. Tumor growth resumed upon drug withdrawal, at a rate seemingly higher where FGFR-1 was highly expressed. These preliminary results confirm the strong activity of E-3810 in a large panel of tumours, with growth control and, sometimes, regressions. Studies are ongoing to enlarge the panel of models and to confirm the observed trend suggesting a somewhat higher sensitivity to E-3810 in tumors expressing higher FGFR-1 and\or FGF ligand. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 595. doi:10.1158/1538-7445.AM2011-595
Abstract 5693: Changes in antioxidant capacities of isolated radish components during growth
Authors: Jonathan Whitaker, Evita Giraldez, Jason Loong, Joel Wagstaff, Richard Robinson, Kim L. O'Neill
Journal: Cancer Research (2010)

Abstract Radishes have been cultivated and used in the diet since the Hellenistic age and have become a common vegetable in grocery stores in North America. Radishes belong to the genus Brassica and recent research has indicated the consumption of this plant has protective properties against colorectal cancer. This project examines the antioxidant (AO) properties of the leaves, stems, body, and the roots of cherry belle radishes at different stages of growth from germination to maturity. For this experiment, AO capacity was measured using the oxygen radical absorbance capacity (ORAC) assay. The ORAC assay involves mixing samples from the radish components with fluorescein, a fluorescence agent, and measuring the degradation of fluorescein after AAPH ((2,2′)-azobis-(2-amidinopropane) dihydrochloride), an oxidizer, is added. Using a trolox (6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid) standard, the results from the ORAC assay were converted to trolox equivalents per liter (TE/L). Results indicate that shortly after germination, about 14 days after planting, the body of the radish plants have the highest mean AO capacity with a TE/L reading of 32, compared to the leaves’ initial reading at 26 TE/L. As the plant nears maturity, 23 days after planting, the leaves become the best source of AO at 78 TE/L, and the body's mean AO capacity reaches 73 TE/L. The stems begin as a relatively weak source of AO at 22 TE/L, but mature to 71 TE/L. The roots of the radish plant were consistently the lowest source of AO at 16 TE/L at day 14, and 61 TE/L at day 23. In addition, a cellular model was used to determine how well the AO are taken into cells that have been distressed. This assay measures the uptake of AO in cells over 10, 20, 45, and 60 minutes after the cells have been exposed to a known oxidant, AAPH. Raji cells, a Burkitt's lymphoma cell line, were treated with samples derived from the same parts of the radish plant after they were pretreated with AAPH. Preliminary data indicate cells continually uptake AO derived from the radish leaves up to and possibly beyond 60 minutes. Pre-stressed cells exposed to AO from stems lose AO capacity over the 60 minutes. In the cells exposed to root samples AO uptake does not change significantly over time. In summary, radish leaves at maturity are the best source of antioxidants. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5693.
SAT0015 Searching for Subclinical Synovitis in Palindromic Rheumatism: An Ultrasound Study in 40 Patients
Authors: S. Cabrera-Villaba, J. Ramirez Garcia, G. Salvador, V. Ruiz-Esquide, M. V. Hernández, C. Saura, J. Cañete, R. Sanmarti
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Palindromic rheumatism (PR) is an intermittent arthritis that may evolve to rheumatoid arthritis (RA), especially in patients with anti-citrullinated protein antibodies (ACPA), although significant numbers of patients do not evolve to RA after several years of follow-up. It is not known whether patients may have subclinical synovitis during the intercritical phase of the disease and whether this is a risk factor for progression to RA. <h3>Objectives</h3> To analyze the presence of subclinical synovitis (measured by power Doppler ultrasound) in patients with pure PR in the asymptomatic phase and compare ultrasound (US) findings in ACPA (+) and ACPA (-) patients. <h3>Methods</h3> Patients diagnosed with pure PR that had not progressed to chronic rheumatic disease at the time of the study were included. Clinical, demographic, serological and therapeutic variables were collected. US assessment of both hands, including the wrists, metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints, and the flexor and extensor tendons of the wrists and hands was performed in all patients during the asymptomatic disease phase. An Esaote USscanner with a MyLab25 12 MHz linear probe was used for all USassays, which were performed by the same rheumatologist, with experience in musculoskeletal US. The US assessment searched for and quantified (grades 0-1-2-3) subclinical synovitis (coexistence of synovial hypertrophy and power Doppler signal) in the areas mentioned above. <h3>Results</h3> 40 patients (70% women), mean age 51.1±11.9 years, mean disease duration 2.4±11.3 years, were included. The most-commonly involved joints during the attacks were: MCP (47.5%), wrist (27.5%), PIP (17.5%). In 47% of patients, the duration of the attackswas&lt; 48hours. Rheumatoid factor (RF) and ACPA (CCP2 commercial test) were positive in 52.5% and 72.5% of patients, respectively. Seventy per cent of patients were treated with DMARDs, most frequently hydroxychloroquine. US showed a power Doppler signal in 13 patients (32.5%), most-frequently in the carpal joints (30%), and second MCP (25%), and 87.5% of patients had some degree of synovial hypertrophy, of which the highest degree was in the carpal joints (35%) and MCP (34.3%). No significant differences in US results were found between ACPA-positive or ACPA-negative patients (Table 1). US performed in 4 patients during RP attacks showed 3 had active synovitis (synovial hypertrophy and power Doppler signal). <h3>Conclusions</h3> US showed most patients with pure PR have some degree of synovial hypertrophy in the joints of the hand in the asymptomatic phase, but only one third had subclinical synovitis (synovial hypertrophy and power doppler signal), with no differences between ACPA-positive and ACPA-negative patients. <h3>Disclosure of Interest</h3> None Declared
Whole-Blood Amino Acids in Experimentally Induced Typhoid Fever in Man
Authors: Ralph D. Feigin, Albert S. Klainer, William R. Beisel, Richard B. Hornick
Journal: New England Journal of Medicine (1968)

A significant increase in whole-blood amino acids was observed during the incubation period of experimentally induced typhoid fever in man. Ten of the 17 subjects became ill. Retrospective analysis of amino acid changes permitted recognition of impending illness in nine of the 10. A significant increase was not observed in any subject in whom clinically apparent disease did not develop. A significant decrease in blood amino acid concentrations was observed to accompany and follow clinical illness in the subjects who were ill. This appeared to correlate more closely with the presence of overt illness rather than mere infection. Blood amino changes may represent one of the earliest detectable metabolic changes after infection. Evidence is rapidly accumulating that evaluation of amino acids may provide a useful tool in the early diagnosis of infection and may yield important clues to the biochemical and physiologic factors involved in the pathogenesis of disease.
BIORESORBABLE SCAFFOLD FOR THE TREATMENT OF LESIONS IN SMALL CORONARY ARTERIES: IVUS INSIGHTS FROM THE ABSORB JAPAN TRIAL
Authors: Kozo Okada, Hideki Kitahara, Kyuhachi Otagiri, Shigemitsu Tanaka, Takumi Kimura, Paul Yock, Peter Fitzgerald, Takeshi Kimura, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2016)
Thyroiditis and Gonadal Dysgenesis
Authors: E. D. Williams, E. Engel, A. P. Forbes
Journal: New England Journal of Medicine (1964)

THE high incidence of Hashimoto's thyroiditis in females as compared to males has been repeatedly confirmed since the original description of the disease in 19121 in 4 patients, all middle-aged women. The female proponderance is also true for the occurrence of thyroid antibody in several control series,2 , 3 and for the incidence of focal thyroiditis in histologic studies by Bastenie4 and Williams and Doniach.5 Because of this, the occurrence of thyroiditis in a patient with primary gonadal failure described by Engel and Forbes6 was of particular interest, and prompted a clinical survey of a group of 25 cases of gonadal dysgenesis . . .
The Angioedema Quality of Life Questionnaire (<scp>AE</scp>‐QoL) – assessment of sensitivity to change and minimal clinically important difference
Authors: K. Weller, M. Magerl, A. Peveling‐Oberhag, P. Martus, P. Staubach, M. Maurer
Journal: Allergy (2016)

The Angioedema Quality of Life Questionnaire (AE-QoL) has recently been developed and validated as the first specific patient-reported outcome tool to assess quality of life (QoL) impairment in recurrent angioedema patients. As of yet, its sensitivity to change and minimal clinically important difference (MCID) have not been established.Recurrent angioedema patients with chronic spontaneous urticaria or hereditary angioedema were repeatedly asked to complete the AE-QoL along with the SF-12 and other anchors for QoL impairment and disease activity during routine care visits. The sensitivity to change of AE-QoL was determined by correlating changes in its scores over time with changes in the applied anchors. In addition, the MCID was determined using anchor-based and distributional criterion-based approaches.Two hundred and seventy-eight patients contributed data sets for analysis. Baseline AE-QoL values were found to correlate well with SF-12 results as well as all other applied anchors for angioedema-related QoL impairment and disease activity. In addition, AE-QoL score changes over time correlated significantly with changes in the above anchors, thus demonstrating its sensitivity to change. The MCID of the AE-QoL total score was found to be six points.The AE-QoL is a valuable tool to assess changes of QoL impairment in recurrent angioedema patients over time, including changes due to treatment.
AB1300 Ultrasound analysis of achilles enthesis erosions recovery capacity in spondyloarthritis
Authors: S. Parisi, A. Lagana’, F. Ambrogio, M. Bruzzone, R. De Giovanni, C. Centanaro Di Vittorio, C.L. Peroni, M. Scarati, E. Fusaro
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Spondyloarthritis (SpA) is characterised by the inflammatory involvment of the enthesis. In the last few years, several studies have provided relevant data on the advantages and validity of using ultrasound (US) to study enthesis in SpA. <h3>Objectives</h3> To evaluate with ultrasound the presence of erosions in Achilles tendons enthesis and their recovery capacity, in spondyloarthritis (SpA). <h3>Methods</h3> A prospective study of Achilles enthesis erosions in SpA was undertaken. US and X-Ray examinations were performed at baseline and at 6 and 12 months of follow-up. Clinical outcomes measures were collected. <h3>Results</h3> Bilateral Achilles enthesis of 45 patients (30 men, 15 women) were investigated. The mean C reactive protein (CRP) levels were 9,9±6,9 mg/L. US visualised 14 erosions (6,3%) in 12 patients. X-Ray 11 erosions in 11 patients (4,9%). At 6 and 12 months of follow-up, 20% and 35% of basal erosion had disappeared, respectively and of the new erosions that appeared at 6 months, 30% had disappeared 6 months later. A stastically significant association between erosion and CRP levels, entheseal Doppler signals, MASES and SPARCC was found. <h3>Conclusions</h3> The recovery capacity of Achilles tendons in SpA seems reasonably related to formation of new bone in the enthesis area. Conclusions: US is reliable and sensitive to evaluate the presence of enthesis erosions and their changes in time, and more sensitive than X-Ray. An association was found between Achilles enthesis erosions and objective activity-based measurements of SpA outcomes. <h3>Disclosure of Interest</h3> None Declared
Abstract 1832: Integrated analysis of clinical ChIPSeq data and public databases identified candidate long non-coding RNAs critically involved in gastrointestinal cancer.
Authors: Reo Maruyama, Eiichiro Yamamoto, Kohei Kumegawa, Akihiro Tsuyada, Masami Ashida, Ryo Suzuki, Takashi Tokino, Yasuhisa Shinomura, Hiromu Suzuki
Journal: Cancer Research (2013)

Abstract Recent work has suggested various important functions and molecular mechanisms for long non-coding RNAs (lncRNAs) and they are also thought to play critical roles in cancer. However the importance of lncRNAs in cancer biology is still unclear. In this study, we sought to comprehensively identify novel lncRNAs that are critically involved in tumorigenesis and progression in gastrointestinal cancer. To identify candidate lncRNAs, we have applied the ChIP-Seq technology to clinical endoscopic biopsy specimens and characterized global histone modification patterns in more than 30 normal tissues and cancers. We developed an original lncRNA database based on several public databases. We then examined histone methylation status around putative lncRNAs and generated a list of candidate lncRNAs that may be important for cancer. In order to narrow the list down, we also utilized publicly available ChIPSeq data as well as bisulfite sequencing and RNASeq data to perform integrated analysis. Finally we identified ∼10 lncRNAs that are abnormally silenced by DNA methylation in gastrointestinal cancer and also identified other ∼10 lncRNAs that are abnormally overexpressed and potentially acting as oncogenic genes in cancer. We are examining gene expression level and epigenetic status of these lncRNAs in cancer cell lines and specimens by qRT-PCR, MSP, bisulfite pyro-sequencing and ChIP assay. Here we would like to show the advantage of making the best use of publicly available multi-omics data to promote long non-coding RNA research. Citation Format: Reo Maruyama, Eiichiro Yamamoto, Kohei Kumegawa, Akihiro Tsuyada, Masami Ashida, Ryo Suzuki, Takashi Tokino, Yasuhisa Shinomura, Hiromu Suzuki. Integrated analysis of clinical ChIPSeq data and public databases identified candidate long non-coding RNAs critically involved in gastrointestinal cancer. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1832. doi:10.1158/1538-7445.AM2013-1832
Abstract 5427: Combination of aflibercept (VEGF trap) and docetaxel produces increased antitumor effects associated with enhanced changes to tumor vasculature
Authors: Cristina Abrahams, Baosheng Li, Asma Parveen, Gavin Thurston
Journal: Cancer Research (2010)

Abstract VEGF blockade in combination with chemotherapy has shown increased anti-tumor efficacy in preclinical models and clinical studies. However, the mechanism by which combination treatments result in enhanced effects is not well understood. In this study, we sought to characterize the mechanism for improved effects of aflibercept plus docetaxel on HT1080, a human fibrosarcoma line that is resistant to anti-VEGF treatment. Immunodeficient SCID mice bearing subcutaneous HT1080 tumors (size ∼100 mm3) were treated with either control protein (hFc) plus docetaxel vehicle, aflibercept (25 mg/kg s.c.), docetaxel (4.5 mg/kg i.v.), or the combination. Following three treatments administered every 3-4 days, tumors were left to grow and harvested when the average size of the treatment group reached ∼600mm3. We found that combination treatment with aflibercept plus docetaxel was significantly more efficacious than either single agent. Although treatments with docetaxel alone and in combination with aflibercept both initially regressed tumor size, the combination was significantly more effective at delaying long-term tumor regrowth. In tumors harvested 24 hrs after the last treatment, combination treatment produced a dramatic decrease in the number of proliferating cells and a concomitant increase in pyknotic cells. Aflibercept or docetaxel alone had only modest effects on the vessels in this tumor, whereas the combination treatment resulted in pruned vessels with less branching, some vessels with punctate endothelial cell staining, and an increase in TUNEL-positive endothelial cells. These results suggest that combination of aflibercept plus taxols (docetaxel) causes enhanced effects on the tumor vessels, thus improving efficacy in tumors with vasculature that exhibit resistance to VEGF blockade. Further understanding the mechanistic basis underlying these combination treatments may provide insight into improving current strategies to manage tumors resistant to antiangiogenic therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5427.