tbuckley/cabot-search huggingface dataset:
Short Pulse of a Small Peptide Agonist of Stromal Cell-Derived Factor - 1 (SDF-1) Enhances the Engraftment of Expanded Human Cord Blood Hematopoietic Progenitor Cells in NOD/SCID Mice.
Authors: Karen Kwai Har Li, Carmen K.Y. Chuen, Shuk Man Lee, Donald Wong, Ahmed Merzouk, Hassan Salari, Patrick M.P. Yuen, Chi Kong Li, Tai Fai Fok, Goldie J.S. Gu, Kam Sze Tsang, Ki Wai Chik, Ping Law
Journal: Blood (2004)
PO77EXPRESSION OF THE ONCOGENIC SPLICE VARIANT OF CYCLIN D1, CCND1B, IN PAEDIATRIC LOW GRADE GLIOMAS
Authors: Jennie N. Jeyapalan, Chirag M. Haria, Tania A. Jones, Ruth G. Tatevossian, Ibrahim Qaddoumi, David W. Ellison, Denise Sheer
Journal: Neuro-Oncology (2015)

INTRODUCTION: Paediatric low-grade gliomas have genetic mutations that result in activation of the MAPK pathway.A key downstream target of the MAPK pathway is the cell cycle regulator cyclin D1 (CCND1), which is up-regulated and mutated in many cancers.Aberrant alternative splicing at the exon4-intron boundary in CCND1 leads to expression of the CCND1b transcript, producing an oncogenic truncated protein.We have investigated whether CCND1b is expressed in pLGGs and have examined the SNP and DNA methylation status at the exon4-intron boundary.METHOD: Real-time PCR was used to investigate expression levels of CCND1 splice variants in 27 paediatric low-grade gliomas and 4 normal brain controls.DNA methylation was analysed using the Illumina HumanMethylation450K beadchip, and the SNP status determined by PCR and Sanger sequencing.Findings were confirmed in an independent tumour cohort.RESULTS: The oncogenic splice variant, CCND1b, was found to be upregulated together with the nononcogenic variant, CCND1a, in both pilocytic and diffuse astrocytomas compared to normal brain.CCND1b expression was significantly higher in diffuse astrocytomas than pilocytic astrocytomas.However, no correlation was found between CCND1b expression and methylation or SNP status across the tumour cohort.CONCLUSION: This study is the first to identify the oncogenic CCND1b splice variant in paediatric low-grade gliomas.The mechanism that leads to oncogenic alternative splicing still needs to be elucidated.As aberrant action of splicing machinery is present in many cancers, our findings warrant further investigation in this group of tumours.
SP0067 Sensitization and Pain in OA
Authors: T. Neogi
Journal: Annals of the Rheumatic Diseases (2016)

Osteoarthritis (OA) is the most common form of arthritis, with the hand, knee and hip being the most prevalent joints affected. Pain is the primary clinical symptoms of knee OA and knee OA itself is a leading cause of disability among older adults worldwide. Yet there are limited management options for the symptoms of knee OA, and no proven therapies that can alter its progression. An improved understanding of pain etiology in knee OA is critical to improving OA outcomes by identifying rational therapeutic targets. While there are data to support the importance of structural pathology as contributing to pain in knee OA, such structural lesions do not fully account for the pain experience in OA. Whereas knee OA pain is typically activity-related earlier in the course of disease, pain can be come chronic later in the disease course, suggesting the possibility of altered neurobiological pathways playing a role in OA pain. Peripheral and central sensitization, which reflect alterations in the ascending nociceptive signals in the peripheral and central nervous systems, respectively, and inadequate descending inhibition can lead to heightened pain sensitivity. Sensitization can be assessed in clinical studies with pressure pain threshold and temporal summation, and assessment of conditioned pain modulation provides insights into efficiency of the descending inhibitory pathways. Conditioned pain modulation has been demonstrated to be abnormal in patients awaiting joint replacement surgery, and to improve post-replacement, raising in the intriguing possibility that certain abnormalities of pain processing can be altered by removing the pathologic tissue. In terms of sensitization, pressure pain threshold is lower (i.e., more pain sensitive and/or sensitized) in subjects with knee OA than in healthy controls around the knee and other anatomic sites on both the ipsilateral and contralateral sides. Lower pressure pain threshold and temporal summation are also associated with higher likelihood of pain presence and severity both at the knee and distant to the knee, but have no clear relation to radiographic severity or duration of disease. However, synovitis and effusion, which are inflammatory lesions in knee OA, are associated with both pressure pain threshold and temporal summation. In contrast, bone marrow lesions, which are largely mechanically-driven lesions in knee OA, are not associated with these measures of sensitization. These results suggest that certain features of knee OA may result in sensitization, and offer a potential avenue for targeted therapy to reduce the occurrence of sensitization, and thereby reduce pain severity in knee OA. <h3>Disclosure of Interest</h3> None declared
Transcriptome Analysis Reveals Molecular Profiles Associated with Evolving Steps of Monoclonal Gammopathies.
Authors: Lucía López Corral, Luis Antonio Corchete, Maria Victoria Mateos, Ramon Garcia-Sanz, Encarna Fermiñán, Juan José Lahuerta, Joan Blade, Albert Oriol, Ana Isabel Teruel, Maria Luz Martino, Jose Hernández, Jesús M Hernández-Rivas, Jesus F San Miguel, Norma Gutierrez
Journal: Blood (2012)
Introduction of Differential KIR Activation Mediated Patters of NK Cell Cytotoxicity Against Myeloma
Authors: Thomas StÜbig, York Hildebrand, Karla Jungk, Aga Konielsk, Lars Lange, Thomas Binder, Heidi Duske, Djordje Atanackovic, Boris Fehse, Thomas Eiermann, Axel R. Zander, Nicolaus Kröger
Journal: Blood (2010)
Abstract 19225: Impact of Change in Resuscitation Guidelines on National Out-of-hospital Cardiac Arrest Outcomes: Fulfilled Expectations?
Authors: Shaker M Eid, Aiham Albaeni, Rebeca Rios, May Baydoun, Bolanle Akinyele, Lekshmi N Raghavakurup, Hind Baydoun, Nisha Chandra-Strobos
Journal: Circulation (2015)

Background: The intent of the 5-yearly Resuscitation Guidelines is to improve outcomes. Previous studies have yielded conflicting reports of a beneficial impact of the 2005 guidelines on out-of-hospital cardiac arrest (OHCA) survival. Using a national database, we examined survival before and after the introduction of both the 2005 and 2010 guidelines. Methods: We used the 2000 through 2012 National Inpatient Sample database to select patients ≥18 years admitted to hospitals in the United States with non-traumatic OHCA (ICD-9 CM codes 427.5 &amp; 427.41). A quasi-experimental (interrupted time series) design was used to compare monthly survival trends. Outcomes for OHCA were compared pre- and post- 2005 and 2010 resuscitation guidelines release as follows: 01/2000-09/2005 vs. 10/2005-9/2010 and 10/2005-9/2010 vs. 10/2010-12/2012. Segmented regression analyses of interrupted time series data were performed to examine changes in survival to hospital discharge. Results: For the pre- and post- guidelines periods, 81600, 69139 and 36556 patients respectively survived to hospital admission following OHCA. Subsequent to the release of the 2005 guidelines, there was a statistically significant worsening in survival trends (β= -0.089, 95% CI -0.163 – -0.016, p =0.018) until the release of the 2010 guidelines when a sharp increase in survival was noted which persisted for the period of study (β= 0.054, 95% CI -0.143 – 0.251, p =0.588) but did not achieve statistical significance (Figure). Conclusion: National clinical guidelines developed to impact outcomes must include mechanisms to assess whether benefit actually occurs. The worsening in OHCA survival following the 2005 guidelines is thought provoking but the improvement following the release of the 2010 guidelines is reassuring and worthy of perpetuation.
Phase Ib Trial of the mTOR Inhibitor Everolimus Given in Combination with Multiagent Chemotherapy in Relapsed Acute Lymphoblastic Leukemia
Authors: Andrew E. Place, Yana Pikman, Kristen Stevenson, Marian H. Harris, Todd M. Cooper, Lia Gore, Nobuko Hijiya, Mignon L. Loh, Melinda Pauly, Maria Luisa Sulis, Donna S Neuberg, Kimberly Stegmaier, Stephen E. Sallan, Lewis B. Silverman
Journal: Blood (2015)
Translocations Involving the IGH@locus Occur In 3.7% of Chronic Lymphocytic Leukemia and Are Associated with Unmutated IGHV Status and a Shorter Time to Treatment: A Study on 2,135 Cases
Authors: Claudia Haferlach, Frank Dicker, Susanne Schnittger, Wolfgang Kern, Torsten Haferlach
Journal: Blood (2010)
Response and Outcomes to Nilotinib at 24 Months in Imatinib-Resistant Chronic Myeloid Leukemia Patients in Chronic Phase (CML-CP) and Accelerated Phase (CML-AP) with and without BCR-ABL Mutations.
Authors: Jerald P. Radich, Giovanni Martinelli, Andreas Hochhaus, Enrico Gottardi, Simona Soverini, Susan Branford, Martin C Müller, Lan Beppu, Yaping Shou, Ariful Haque, Richard C. Woodman, Hagop M. Kantarjian, Timothy P. Hughes, Dong-Wook Kim, Giuseppe Saglio
Journal: Blood (2009)
Candidate Pathway Approach of Single Nucleotide Polymorphism On Imatinib Transport/Metabolism Pathway and DNA Repair Enzyme Pathway Associated with Response and Resistance to Imatinib Therapy in Chronic Myeloid Leukemia.
Authors: Jung A. Kim, Dong Hwan Dennis Kim, Young Woong Won, Silvia Park, Hee-Jin Kim, Sun-Hee Kim, Jun Ho Jang, Kihyun Kim, Yeo-Kyeoung Kim, Je-Jung Lee, Hyeoung-Joon Kim, Joon Ho Moon, Sang Kyun Sohn, Chul Won Jung
Journal: Blood (2009)
Therapeutic Plasma Exchange (TPE) for Thrombotic Thrombocytopenic Purpura (TTP) Using Plasma Prepared with Photochemical Treatment (INTERCEPT Plasma).
Authors: Paul D. Mintz, A. Neff, M. MacKenzie, C. Hillyer, L. T. Goodnough, C. Kessler, K. McCrae, J. Menitove, L. Damon, I. Lopez, C. Roualt, K. Crookston, R. J. Benjamin, J. George, S. Van Doren, J. S. Lin, L. Corash
Journal: Blood (2004)
PWE-073 Comparison of Cost-Effectiveness Between 96 Hour Wireless Bravo Reflux Monitoring and 24 Hour PH-Impedance in The Diagnosis of Gastroesophageal Reflux Disease: Abstract PWE-073 Table 1
Authors: GN Ho, TA James, T Wong, J Jafari
Journal: Gut (2016)

<h3>Introduction</h3> 24 hour pH-impedance reflux monitoring is considered the gold standard in diagnosing pathological gastroesophageal reflux (GOR). Alternative method is catheter-free Bravo capsules (96 hours). To date, their cost-effectiveness has yet to be compared. At Guy’s Hospital, London, UK, the cost of Bravo is estimated to be £1,200 (including endoscopy) and pH-impedance to be £800 (including high resolution manometry). It is generally assumed that the higher cost of Bravo monitoring is justifiable as it is thought to have a higher diagnostic yield due to better patient compliance and a longer monitoring time. <h3>Methods</h3> Patients who had a Bravo or pH-impedance study during May-November 2015 were selected. The more cost-effective method was defined as the technique with lower cost (including cost of non-diagnostic results) per diagnostic procedure. To identify non-diagnostic results, the patients with pathological GOR, patients with positive symptom-reflux associations, patients with supragastric belching and patients who were adequately symptomatic (therefore having negative symptom-reflux association) were removed. Positive symptom-reflux association was considered as symptom association probability (SAP) ≥95% and/or symptom index (SI) ≥50%. <h3>Results</h3> 81 Bravo patients and 145 pH-impedance patients were analysed. 50 (61.7%) Bravo patients and 69 (47.5%) pH-impedance patients were diagnosed with pathological GOR, 14 (17.3%) Bravo and 44 (30.3%) pH-impedance patients had hypersensitive oesophagus, 3 (2.1%) pH-impedance were patients diagnosed with supragastric belching causing symptoms, and 10 (12.3%) Bravo and 14 (9.7%) pH-impedance patients experienced symptoms unexplained by reflux events (negative symptom-reflux association). The remaining 7 (8.6%) Bravo and 15 (10.3%) pH-impedance entries therefore represent the proportion of non-diagnostic investigations. Cost calculations revealed that each Bravo with diagnostic yield costs £1313.5 whilst each pH-impedance with diagnostic yield costs £892.3 (Table 1). This means that for each diagnosis made by Bravo there is an additional cost of £421.2. <h3>Conclusion</h3> The cost-effectiveness of pH-impedance reflux monitoring seems to be superior to Bravo system to make a reflux-related diagnosis. However, this study does not take into account other advantages of each method in clinical use. <h3>Disclosure of Interest</h3> None Declared
Genomic Landscape of Pediatric CBF-AML By SNP-Array Karyotyping and Extensive Mutational Analysis
Authors: Nicolas Duployez, Elise Labis, Alice Marceau-Renaut, Christine Ragu, Arnaud Petit, Anne Auvrignon, Christophe Roumier, Olivier Nibourel, Jonathan Bond, Martin Figeac, Paola Ballerini, Gérard Michel, Yves Bertrand, Virginie Gandemer, Elizabeth Macintyre, Meyling Cheok, André Baruchel, Guy Leverger, Claude Preudhomme, Hélène Lapillonne
Journal: Blood (2014)
]Socioeconomic Factors May Select Adults Younger Than 60 Years of Age with “De Novo” Acute Myeloid Leukemia To Receive Intensive Treatment outside a Clinical Trial in Developing Countries. Experience of a Brazilian University Center.
Authors: Evandro M. Fagundes, Vanderson Rocha, Ana Beatriz F. Glória, Nelma Cristina D. Clementino, José S. Quintão, Joao Paulo O. Guimaraes, Enio Roberto P. Pedroso, Marcos B. Viana
Journal: Blood (2004)
N-Acetylcysteine Treatment in Two Patients with Relapsed Thrombotic Thrombocytopenic Purpura Increased ADAMTS13 Activity, Free Thiol Concentration in Plasma, and Inhibited Platelet Activation
Authors: Junmei Chen, Tahsin Özpolat, Colette Norby, Jennie Le, Minhua Ling, Shelby A Cate, Dominic W Chung, Xiaoyun Fu, Barbara Konkle, Jose A. Lopez
Journal: Blood (2015)
Reduction of the Six-Minute Walk Distance in Children with Sickle Cell Disease Is Correlated with Silent Infarct: Results From a Cross-Sectional Evaluation in a Single Center in Belgium.
Authors: Rudy Chapusette, Laurence Dedeken, Phu-Quoc Le, Catherine Heijmans, Christine Devalck, Sophie Huybrechts, France Ziereisen, Laurence Hanssens, Malou Ngalula, Alina Ferster
Journal: Blood (2012)
PTU-032 Iron Deficiency Anaemia (IDA) and Normal Upper and Lower Gastrointestinal Endoscopies: Long Term Outcomes for Patients Investigated According to British Society of Gastroenterology (BSG) Guidelines
Authors: G Perin, R Young, M Rogers
Journal: Gut (2016)

<h3>Introduction</h3> Limited outcome data exists for patients with iron deficiency anaemia (IDA) investigated in accordance with the British Society of Gastroenterology (BSG) guidelines following normal gastrointestinal endoscopy.<sup>1</sup> The importance of missed diagnoses in such patients is a key quality indicator for endoscopy services.<sup>2</sup> The aim of this study was to evaluate long term outcomes for patients with IDA and normal upper and lower gastrointestinal endoscopy managed in accordance with BSG guidelines.<sup>1</sup> <h3>Methods</h3> Review of a large consecutive series of adult patients referred for investigation of IDA from 1999–2006 to a UK district general hospital. All patients underwent successful oesophago-gastro-duodenoscopy (OGD) and colonoscopy. Those who received a definitive diagnosis were excluded (colorectal/upper gastrointestinal carcinoma, coeliac disease or inflammatory bowel disease). If endoscopic assessment found no cause for IDA no further investigations were undertaken aside from colonic adenoma surveillance. Case notes, laboratory, endoscopy and radiology records were reviewed to determine recurrence and re-investigation of IDA in these patients, any significant gastrointestinal pathology and patient outcomes. Survival was determined using the Kaplan-Meier technique. <h3>Results</h3> 116 of 142 (82.3%) referred patients had no cause found for IDA on index endoscopic evaluations. Over a median follow up period of 12 years (153 months, range 108–192) there were 45 deaths in this cohort. 5- and 10 year survival rates were 91% and 74% respectively. 23 (19.8%) patients were re-referred for investigation of IDA of which 20 had further normal endoscopies. Overall 2 (1.7%) patients were diagnosed with gastrointestinal cancers during the period of follow up we reviewed. Neither could obviously be classified as a missed diagnosis; one oesophageal and one gastric cancer were diagnosed 12 years post index investigations. All endoscopies that patients subsequently underwent following index investigations were reviewed, including those for other indications and screening. In total 38 patients underwent endoscopy and one had a CT virtual colonoscopy. One patient was diagnosed with terminal ileal Crohn’s disease following re-referral with change in bowel habit 2 years after index investigations and one had haemorrhoids diagnosed on flexible sigmoidoscopy. <h3>Conclusion</h3> Patients with IDA and normal upper and lower gastrointestinal endoscopies who were managed in accordance with BSG guidelines had acceptable long term outcomes. Overall this data supports the recommendations made by the BSG. <h3>References</h3> 1 Goddard AF, <i>et al. Gut</i> 2011;<b>60</b>(10):1309–16. 2 Morris EJ, <i>et al. Gut</i> 2015;<b>64</b>(8):1248–56. <h3>Disclosure of Interest</h3> None Declared
Sex-Specific Alterations of White Matter Developmental Trajectories in Infants With Prenatal Exposure to Methamphetamine and Tobacco
Authors: Linda Chang, Kenichi Oishi, Jon Skranes, Steven Buchthal, Eric Cunningham, Robyn Yamakawa, Sara Hayama, Caroline S. Jiang, Daniel Alicata, Antonette Hernandez, Christine Cloak, Tricia Wright, Thomas Ernst
Journal: JAMA Psychiatry (2016)

Methamphetamine is a common illicit drug used worldwide. Methamphetamine and/or tobacco use by pregnant women remains prevalent. However, little is known about the effect of comorbid methamphetamine and tobacco use on human fetal brain development.To investigate whether microstructural brain abnormalities reported in children with prenatal methamphetamine and/or tobacco exposure are present at birth before childhood environmental influences.A prospective, longitudinal study was conducted between September 17, 2008, and February 28, 2015, at an ambulatory academic medical center. A total of 752 infant-mother dyads were screened and 139 of 195 qualified neonates were evaluated (36 methamphetamine/tobacco exposed, 32 tobacco exposed, and 71 unexposed controls). They were recruited consecutively from the community.Prenatal methamphetamine and/or tobacco exposure.Quantitative neurologic examination and diffusion tensor imaging performed 1 to 3 times through age 4 months; diffusivities and fractional anisotropy (FA) assessed in 7 white matter tracts and 4 subcortical brain regions using an automated atlas-based method.Of the 139 infants evaluated, 72 were female (51.8%); the mean (SE) postmenstrual age at baseline was 41.5 (0.27) weeks. Methamphetamine/tobacco-exposed infants showed delayed developmental trajectories on active muscle tone (group × age, P < .001) and total neurologic scores (group × age, P = .01) that normalized by ages 3 to 4 months. Only methamphetamine/tobacco-exposed boys had lower FA (group × age, P = .02) and higher diffusivities in superior (SCR) and posterior corona radiatae (PCR) (group × age × sex, P = .002; group × age × sex, P = .01) at baseline that normalized by age 3 months. Only methamphetamine/tobacco- and tobacco-exposed girls showed persistently lower FA in anterior corona radiata (ACR) (group, P = .04; group × age × sex, P = .01). Tobacco-exposed infants showed persistently lower axial diffusion in the thalamus and internal capsule across groups (P = .02).Prenatal methamphetamine/tobacco exposure may lead to delays in motor development, with less coherent fibers and less myelination in SCR and PCR only in male infants, but these abnormalities may normalize by ages 3 to 4 months after cessation of stimulant exposure. In contrast, persistently less coherent ACR fibers were observed in methamphetamine/tobacco- and tobacco-exposed girls, possibly from increased dendritic branching or spine density due to epigenetic influences. Persistently lower diffusivity in the thalamus and internal capsule of all tobacco-exposed infants suggests aberrant axonal development. Collectively, prenatal methamphetamine and/or tobacco exposure may lead to delayed motor development and white matter maturation in sex- and regional-specific manners.
Monosomal Karyotype (MK) In Older Patients with Acute Myeloid Leukemia (AML) on Eastern Cooperative Oncology Group (ECOG) Therapeutic Trials: Poor Prognostic Impact of MK, but Not of Monosomy 7
Authors: Stephen A Strickland, Zhuoxin Sun, Rhett P Ketterling, Athena M Cherry, Larry D Cripe, Gordon Dewald, Rodney R Higgins, Hillard M Lazarus, Mark R Litzow, Selina M Luger, Elisabeth Paietta, Jacob M Rowe, Hajime Uno, Gail H Vance, Martin S Tallman
Journal: Blood (2010)
SP0100 Awareness and Use among Patients with Inflammatory Rheumatic Disease of Objective and Subjective Assessments of Physical Activity
Authors: B.A. Esbensen
Journal: Annals of the Rheumatic Diseases (2016)

People with inflammatory arthritis (IA) are more physical inactive and sedentary than the general population, which can have serious health consequences such as increased risk of cardiovascular diseases and diabetes. Increasing physical activity levels (PA) (even light intensity) and reduction of sedentary behaviour (SB) have been proved in intervention studies to be feasible for patients and also found to be associated with improvements in health outcomes, such as quality of life, fatigue, pain, physical function and self-efficacy. Different tools can be used to measure PA. Subjective and objective measures have been used in both clinical practice and in research to assess PA and SB including questionnaires, diaries, pedometry, accelerometry, multi-sensor and observational methods. However, knowledge about patients9 perspective, awareness and use of different tools to measure own level of PA and SB is still scarce. Anyhow, it is crucial for health professionals to gain insight in patients9 attention to both objective and subjective assessments of PA to give advises to patients about such tools. Behavioural approaches such as making use of self-monitoring has been integrated in studies targeting both increasing PA and reduction of SB in people with IA, showing positive effects. These positive effects might be an issue for health professionals to take advantage of and e.g. teach patients about being physically active and how to make different tools be a part of own self-management. Data from an international cross-sectional study will be presented investigating the awareness and use of objective and subjective measures of physical activity for patients with IA in Sweden, Ireland, Belgium and Denmark. <h3>Disclosure of Interest</h3> None declared
P0833 : Simeprevir- and telaprevir-based triple therapies for genotype 1b chronic hepatitis C patients aged 70 and over in a multicentre cohort study
Authors: N. Furusyo, E. Ogawa, E. Kajiwara, H. Nomura, A. Kawano, K. Takahashi, K. Dohmen, T. Satoh, K. Azuma, M. Nakamuta, T. Koyanagi, K. Kotoh, S. Shimoda, J. Hayashi
Journal: Journal of Hepatology (2015)
Immunomodulatory Effects and Adaptive Immune Response to Daratumumab in Multiple Myeloma
Authors: Jakub Krejcik, Tineke Casneuf, Inger Nijhof, Bie Verbist, Jaime Bald, Torben Plesner, Kevin Liu, Niels W.C.J. van de Donk, Brendan Weiss, Tahamtan Ahmadi, Henk M. Lokhorst, Tuna Mutis, A. Kate Sasser
Journal: Blood (2015)