tbuckley/cabot-search huggingface dataset:
Coronary Computed Tomography Angiography in the Evaluation of Chest Pain of Suspected Cardiac Origin
Authors: Marcio Sommer Bittencourt, Edward A. Hulten, Vikas Veeranna, Ron Blankstein
Journal: Circulation (2016)

man with history of dyslipidemia is evaluated in the outpatient setting for several months of intermittent atypical chest pain.He is not on any medical therapy.His resting heart rate in the office is 70 beats per minute.His outpatient cardiologist is wondering if coronary computed tomography angiography may be useful for further evaluation.
Abstract B82: Application of modulated electro-hyperthermia for the cellular target therapy in ovarian cancer cells.
Authors: Wookyeom Yang, Doo Byung Chay, Hanbyoul Cho, Sunghoon Kim, Jinkyoung Kong, Geumseon Son, Jihui Choi, Kim Jae-hoon.
Journal: Clinical Cancer Research (2016)

Abstract Background: Oncothermia as modulated electro-hyperthermia is an anti-cancer therapy that was approved by TUV-SUD in Germany, Health Canada in Canada, and Therapeutic Goods Administration in Australian. Oncothermia induces apoptosis via destroying the plasma membrane of cancer cells and leads to accumulation of heat-induced damages mostly in cells located in the tumor tissue while providing minimal damages to the surrounding normal tissue. Thus, oncothermia has recently become a potentially effective therapeutic tool for cancer. Methods: LabEHY-100, an oncothermia device from Oncotherm (Germany &amp; Hungary), was used for all in vitro studies. Ovarian cells were exposed to thermal damage induced by LabEHY-100, and subsequently, the cancer cells were analyzed in terms of viability, levels of apoptosis, autophagic markers and cell cycle status. In addition, xenograft tumors which generated by OVCAR-3 and patients derived tumor, were exposed to thermal damage induced by LabEHY-100 after which the tumor progression was monitored. The efficacy of combination therapy using both oncothermia and 3-methyladenine (3-MA), an autophagy inhibitor, was assessed using crystal violet assay. Results: Our studies showed that oncothermia resulted in growth inhibition in ovarian cancer cell tested. Apoptotic markers such as cleaved caspase-3 and PARP were upregulated in cells exposed to oncothermia compared to the control cells exposed to hyperthermia. Oncothermia also led to reduction in the mass and the volume of the tumors in the mouse transplanted with xenografts derived from cancer cells and ovarian cancer patient tumors. FACS analysis showed that cell cycles of these cells were not disrupted by oncothermia. Still there was a significant increase in the number of sub-G1 population, which consisted of dying cells including apoptotic cells. However, the xenograft cells recovered from cellular damage even after inducing autophagy via oncothermia. Combined treatment with oncothermia and 3-MA, a autophagy inhibitor, was more effective in inhibiting cancer cell growth than treatment with each alone. Conclusion: Oncothermia can potentially be an effective therapy for ovarian cancer cells. Conflict of interest : We obtained funding and in vitro device for electro-hyperthermia from HOSPICARE. Co., Ltd. (Seoul, Republic of Korea). Citation Format: Wookyeom Yang, Doo Byung Chay, Hanbyoul Cho, Sunghoon Kim, Jinkyoung Kong, Geumseon Son, Jihui Choi, Kim Jae-hoon. Application of modulated electro-hyperthermia for the cellular target therapy in ovarian cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B82.
Relationship between efficacy outcomes and weight gain during treatment of advanced, non-squamous, non-small-cell lung cancer patients
Authors: J.D. Patel, J.R. Pereira, J. Chen, J. Liu, S.C. Guba, W.J. John, M. Orlando, G. Scagliotti, P.D. Bonomi
Journal: Annals of Oncology (2016)
Diagnosis of hysterical seizures in epileptic patients
Authors: S V Ramani, L F Quesney, D Olson, R J Gumnit
Journal: American Journal of Psychiatry (1980)

The coexistence of epileptic and hysterical seizures in the same patient is not rare and creates problems in diagnosis and management. The authors used simultaneous video-EEG monitoring to document the diagnosis of hysterical seizures in 9 epileptic patients; clear-cut hysterical seizures were seen in all 9. The authors used individualized re-educative psychotherapy to teach patients alternative coping techniques and discharged them on minimum dosages of anticonvulsants. None of the patients had a classical hysterical personality, which suggests that conversion reaction is a more appropriate diagnosis, The etiology of "hysterical" seizures varies; the authors emphasize individualized treatment and long-term follow-up.
Clinical Reports and Demonstrations: Section of Obstetrics and Gynæcology: Intra- and Extra-uterine Pregnancy. Excision of Extra-uterine Pregnancy in the Fourth Month. together with the Rudimentary Horn of the Uterus, followed by Full-term Delivery of the Intra-uterine Pregnancy
Authors: J. Bright Banister
Journal: Journal of the Royal Society of Medicine (1937)
P-183 Neoadjuvant treatment in borderline resectable pancreatic adenocarcinoma (PA): A single center series
Authors: H. Verdaguer Mata, B. Laquente, J. Busquets, N. Pelaez, L. Secanella, D. Leiva, S. Ruiz, I. Peiro, R. Lopez Urdiales, T. Serrano, S. Vazquez, M. Calvo, O. Serra, M. Cambray, F.J. Perez Martin, C. Sanchez, M. Galan, J. Fabregat
Journal: Annals of Oncology (2015)
Mouse glomerular epithelial cells in culture with features of podocytes in vivo express aminopeptidase A and angiotensinogen but not other components of the renin-angiotensin system.
Authors: S Mentzel, J P Van Son, A S De Jong, H B Dijkman, R A Koene, J F Wetzels, K J Assmann
Journal: Journal of the American Society of Nephrology (1997)

The binding of antibodies to podocytic antigens such as the Heymann antigen or aminopeptidase A may lead to the induction of a membranous glomerulonephritis in several species. To study the possible future interactions of antibodies with antigens on these podocytes, epithelial cells from isolated mouse glomeruli were cultured. By indirect immunofluorescence, the cells were positive for cytokeratin, vimentin, desmin, and the ZO-1 protein, a component of the tight junction complex. When rat monoclonal antibodies were used, the cells were also positive for the hydrolases aminopeptidase A and dipeptidyl peptidase IV, and they stained with ASD-33, a monoclonal antibody that recognized an epitope only present on the cell membranes of mouse podocytes. They were negative for the von Willebrand factor and did not stain with a monoclonal antibody (ASD-13) that binds to endothelial cells of glomeruli and peritubular capillaries. By electron microscopy, the cells showed tight junctions but lacked Weibel Palade bodies (endothelium), desmosomes, and cilia (parietal epithelium). The mRNA expression of several components of the renin-angiotensin system was also examined, and some factors indirectly coupled to the renin-angiotensin system component angiotensin II in this podocytic culture by RT-PCR analysis. mRNA Expression for the angiotensin II degrading hydrolase aminopeptidase A and angiotensinogen was found, but this was not found for any other component of this system, such as renin, angiotensin-converting enzyme, or the angiotensin II receptors AT1a, AT1b, and AT2. Low mRNA expression for dipeptidyl peptidase IV was observed. In addition, expression of the growth factors transforming growth factor-beta and interleukin-7, and the extracellular matrix components fibronectin, laminin B2, perlecan, and collagen IV alpha 1, was observed. Given these characteristics, a glomerular epithelial cell culture with features of podocytes in vivo that will allow future studies on the interaction of anti-aminopeptidase A monoclonal antibodies and angiotensin II with aminopeptidase A was established. This is of interest in light of the observation that injection of mice with anti-aminopeptidase A antibodies causes an acute albuminuria.
SAT0642-HPR Mothers with Scleroderma and Systemic Lupus Erythematosus: Challenges, Limitations, and Adaptation
Authors: J. Poole
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Becoming a mother fulfills a compelling central occupation for many women. Chronic diseases such as scleroderma and lupus frequently emerge and affect women during child bearing and rearing years.[1] Raising children while managing such a disease can be both highly valued yet overwhelming, but has received relatively little attention in both the general and occupational therapy literature. <h3>Objectives</h3> A qualitative interview study was conducted to identify the challenges to mothering experienced by mothers with scleroderma and/or lupus. <h3>Methods</h3> Mothers living in the community were recruited from the Scleroderma Foundation and Lupus Foundation of America websites and from local chapters. Women had to be diagnosed with scleroderma or lupus and have at least one child 18 years and under living with them. A purposive sampling of 27 mothers (14 with scleroderma, 9 with lupus, 4 both diseases; M age =40.0) participated in on-line focus groups. Questions were posted on a discussion board every 2-3 days over a period of weeks with probes added to stimulate conversation and interaction. The interviews consisted of questions regarding key information needed regarding parenting; aspects of scleroderma or lupus that interfered with parenting; what would make parenting with scleroderma or lupus easier; support that would make parenting easier, and advice to other mothers with scleroderma or lupus. Data analysis of transcripts from the focus groups included content analysis of the group data in response to individual questions. Thematic analysis based on an analysis technique called immersion and crystallization was preformed across the data set [2]. <h3>Results</h3> The analysis revealed 6 themes: surviving to raise the children, prioritizing the children9s needs, managing physical impairments, managing the environment, how children cope, and securing support. Mothers fear their own mortality but wanted to put their children9s needs first. They modified activities based on their physical impairments and the environment (cold for scleroderma, sun for lupus). Children and partners/spouses were for the most part were supportive, yet some were in denial. <h3>Conclusions</h3> Mothering is a key component of the lives of women with scleroderma and lupus. Many of the additional stressors of parenting with a chronic illness are not immediately apparent. Questions concerning parenting and needed support services should be a routine part of assessment of women with chronic disease. <h3>References</h3> Dziedzic K, Hammond A (2010). Rheumatology: Evidence-based practice for physiotherapists and occupational therapists. Edinburgh: Elsevier. Borkan J (1999). Immersion/crystallization. In Crabtree BF, Miller WL (Eds). Doing qualitative research (2nd ed., pp 179-194). Thousand Oaks, CA: Sage. <h3>Disclosure of Interest</h3> None declared
Cytochemical Studies of Milk-Adapted Murine Lymphoma Cells (Strain P388 D&lt;sub&gt;1&lt;/sub&gt;) Infected With Polyoma Virus
Authors: Robert Love, Alan S. Rabson
Journal: JNCI Journal of the National Cancer Institute (1959)

Some aspects of the cytochemistry of milk-adapted murine lymphoma cells are presented. Infection of the cells with polyoma virus produces an alteration in the ribonucleoprotein (RNP) of the parachromatin of the nucleolus and nucleoplasm, and enlargement of the nucleus, nucleolus, and cytoplasm; vacuoles containing an abnormal RNP appear in the nucleus. Cell degeneration is completed by nuclear and cytoplasmic shrinkage, disappearance of cytoplasmic RNP, and karyorrhexis. It is suggested that the mechanisms of synthesis of normal RNP in the nucleus may be diverted to the production of RNP that is related to viral synthesis.
&lt;TITLE&gt;Acute Renal Failure&lt;/TITLE&gt;
Authors: Sharon Parmet, Cassio Lynm, Richard M Glass
Journal: JAMA (2002)

Acute Renal Failure R enal failure occurs when the kidneys are unable to do their job: to filter wastes from the blood, help regulate blood pressure, and regulate salt and water balances in the body.As blood flows through the kidneys, it is filtered, and wastes are removed and sent to the bladder as urine.If kidney function becomes impaired, acute (rapid) or chronic (gradually developing) renal failure may occur.With acute renal failure, kidney function can return to normal if the underlying cause of the failure is discovered and successfully treated.The November 27, 2002, issue of JAMA includes an article about treatment of acute renal failure.
Molecular detection and phylogenetic analysis of West Nile virus lineage 2 in sedentary wild birds (Eurasian magpie), Greece, 2010
Authors: G Valiakos, A Touloudi, C Iacovakis, L Athanasiou, P Birtsas, V Spyrou, C Billinis
Journal: Eurosurveillance (2011)

A West Nile virus (WNV) lineage 2 strain was molecularly identified and characterised in a Eurasian magpie hunted in Greece in 2010, during a WNV outbreak in humans. Phylogenetic analysis revealed the highest sequence similarity (>99%) with other WNV lineage 2 strains derived from birds of prey in Austria and Hungary (2004–2009). This first molecular detection of WNV in sedentary wild birds in Greece, which are possible reservoirs of the virus, is a public health concern.
A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers
Authors: Masaki Takeuchi, Michael J Ombrello, Yohei Kirino, Burak Erer, Ilknur Tugal-Tutkun, Emire Seyahi, Yilmaz Özyazgan, Norman R Watts, Ahmet Gül, Daniel L Kastner, Elaine F Remmers
Journal: Annals of the Rheumatic Diseases (2016)

Endoplasmic reticulum aminopeptidase-1 (ERAP1) protein is highly polymorphic with numerous missense amino acid variants. We sought to determine the naturally occurring ERAP1 protein allotypes and their contribution to Behçet's disease.Genotypes of all reported missense ERAP1 gene variants with 1000 Genomes Project EUR superpopulation frequency >1% were determined in 1900 Behçet's disease cases and 1779 controls from Turkey. ERAP1 protein allotypes and their contributions to Behçet's disease risk were determined by haplotype identification and disease association analyses.One ERAP1 protein allotype with five non-ancestral amino acids was recessively associated with disease (p=3.13×10-6, OR 2.55, 95% CI 1.70 to 3.82). The ERAP1 association was absent in individuals who lacked HLA-B*51. Individuals who carry HLA-B*51 and who are also homozygous for the haplotype had an increased disease odds compared with those with neither risk factor (p=4.80×10-20, OR 10.96, 95% CI 5.91 to 20.32).The Behçet's disease-associated ERAP1 protein allotype was previously shown to have poor peptide trimming activity. Combined with its requirement for HLA-B*51, these data suggest that a hypoactive ERAP1 allotype contributes to Behçet's disease risk by altering the peptides available for binding to HLA-B*51.
Abstract 19546: Silencing miR-144 Enhances Regression and Reduces Progression of Atheroscleoris
Authors: Elizabeth Tarling, Joan Cheng, XiaoHui Wu, Peter Tontonoz, Tamer Sallam, Thomas Vallim
Journal: Circulation (2015)

Enhancing cholesterol removal from macrophages in atherosclerotic plaques remains a major unmet pharmacological need. MicroRNA therapeutics are one approach that is currently being evaluated. MicroRNAs fine tune gene expression, and those that target ABCA1, the major cholesterol efflux transporter, are candidates for therapeutic approaches. Silencing microRNAs that target ABCA1 result in increased ABCA1 levels and activity and therefore enhance lipid removal from lesion macrophages. We previously showed that miR-144 targets ABCA1 by binding to at least 2 binding sites in the 3’ UTR region. We have now tested whether silencing miR-144, which increases ABCA1, affects atherosclerosis in two models. First, LDLR-/- mice were fed a western-type diet for 16 weeks, before being switched to regular rodent chow to promote lesion regression. One group of mice were sacrificed after 16 weeks of western diet (baseline), and the remaining animals were randomly assigned to one of 3 groups; vehicle (PBS), control anti-miR, or anti-miR-144 for 4 weeks. Silencing miR-144 significantly decreased atherosclerosis by en face analysis by 20% compared to either control. Further, silencing miR-144 modestly increased plasma HDL levels by 14%, in line with previous studies. To determine whether silencing miR-144 enhanced macrophage cholesterol efflux in mice, we used the same experimental approach. However, 2 days prior to the sacrifice, mice were injected with macrophages that had been loaded with radiolabelled cholesterol. Silencing miR-144 in vivo enhanced macrophage cholesterol efflux to plasma, liver and feces, suggesting the mechanism for the reduced atherosclerosis is due to increased cholesterol removal from plaques. Finally, we also determined whether silencing miR-144 decreased progression of atherosclerosis. LDLR-/- mice were fed a western-style diet for 16 weeks, and, at the same time, mice were treated mice with either anti miR-144, control anti miR or vehicle (PBS). Silencing miR-144 decreased atherosclerosis progression by 33% relative to controls, while HDL levels were also modestly increased (19%). Our results indicate that silencing miR-144 is a potential therapeutic strategy to reduce atherosclerosis, in both regression and progression models.
Research in 'Prostatitis Syndromes': The Use of Alfuzosin (a New α(1)-Receptor-Blocking Agent) in Patients Mainly Presenting with Micturition Complaints of an Irritative Nature and Confirmed Urodynamic Abnormalities
Authors: J J de la Rosette, H F Karthaus, P E van Kerrebroeck, T de Boo, F M Debruyne
Journal: European Urology (1992)
Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms
Authors: H Wetzel, A Hillert, G Gründer, O Benkert
Journal: American Journal of Psychiatry (1994)

Twenty schizophrenic inpatients with either predominantly positive or predominantly negative symptoms were treated with the dopamine autoreceptor agonist roxindole in prospective open clinical trials. There was no antipsychotic effect in the subgroup with positive symptoms, whereas the subgroup with negative symptoms, especially those with the residual type of schizophrenia, showed a moderate but significant 20% reduction in total scores on the Scale for the Assessment of Negative Symptoms.
High Levels of Met-72 Antigen Expression: Correlation With Metastatic Activity of B6 Melanoma Tumor Cell Variants&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: A K Kimura, J H Xiang
Journal: JNCI Journal of the National Cancer Institute (1986)

In the present study, both poorly and highly metastatic clones derived from the C57BL/6 mouse B16 melanoma were used with cyclophosphamide in an attempt to elicit host antibody responses against cell surface markers expressed on highly metastatic tumor variants. The immunizations, performed in both syngeneic and xenogeneic combinations in Lewis rats, resulted in the production of 3 mouse and 2 rat monoclonal antibodies (MoAb) that preferentially react with highly metastatic clones derived from the B16 melanoma. These MoAb all immunoprecipitated a 72,000-dalton, cell surface-expressed glycoprotein, referred to as Met-72. In this study, 2 of the mouse anti-Met-72 MoAb were examined in detail for a) tumor specificity, b) reactivity against normal mouse tissue by in vivo absorption, and c) their ability to discriminate highly metastatic clones derived from the B16 melanoma.
Adolescent cancer patient and physician responses to a questionnaire on patient concerns
Authors: B Pfefferbaum, P M Levenson
Journal: American Journal of Psychiatry (1982)

In order to help physicians provide informational support to young patients with cancer, 63 adolescent cancer patients and 53 physicians completed self-administered questionnaires; 30 disease-related information items were included on the questionnaire. Although physicians and patients agreed on one-half of the items, they differed significantly on the others. Physician responses were not significantly related to the physicians' level of training, suggesting that education programs on this topic should be required at all levels of medical training. Psychiatrists may have a role to play in designing these programs.
Pneumococcal Diseases
Authors: Janet M. Torpy, Alison E. Burke, Richard M. Glass
Journal: JAMA (2006)

Pneumococcal DiseasesT he pneumococcus, a type of bacteria in the Streptococcus family (Streptococcus pneumoniae), is responsible for several types of diseases in adults and in children.In developing countries, pneumococcus is linked to high infant and child mortality rates.Even in more industrialized nations, pneumococcal diseases are common in adults and children.These diseases can lead to severe illness and even death, despite being preventable in many cases.The April 12, 2006, issue of JAMA includes an article about pneumococcal diseases and the beneficial effect of pneumococcal vaccination in infants and children.
A Transplantable Acute Leukemia in an Inbred Line of Rats&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: W. F. Dunning, M. R. Curtis
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article A Transplantable Acute Leukemia in an Inbred Line of Rats Get access W. F. Dunning, W. F. Dunning Cancer Research Laboratory3, Division of Research and Industry, University of Miami, Coral Gables, Florida Search for other works by this author on: Oxford Academic PubMed Google Scholar M. R. Curtis M. R. Curtis Cancer Research Laboratory3, Division of Research and Industry, University of Miami, Coral Gables, Florida Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 5, November 1957, Pages 845–853, https://doi.org/10.1093/jnci/19.5.845 Published: 01 November 1957 Article history Received: 16 August 1955 Published: 01 November 1957
Abstract 14300: Agonal Respiration With and Without Carotid Pulsation on Emergency Medical Technician’s Arrival at Patient
Authors: Hideo Inaba, Yutaka Takei, Takahisa Kamikura, Akira Funada, Yukihiro Wato, Satoru Sakagami, Yasuhiro Myojo
Journal: Circulation (2015)

Aim: To determine the association between agonal respirations with and without carotid pulsation and neurologically favorable one-year survival from OHCAs. Methods and Results: Data for resuscitation-attempted, 7,048 OHCAs were prospectively collected during the period of 2007-2013 in Ishikawa Prefecture. Of these, 6,600 cases were in deep coma, and had agonal respiration (N = 238) or no respiration (N = 6,362). Carotid pulse was present in 26 (10.9%) of 238 cases with agonal respiration, and in 34 (0.5%) of 6,382 cases with no respiration (respiratory arrest cases in the narrow sense). The rate of neurologically favorable one-year survival in the agonal respiration with pulse, agonal respiration without pulse, no respiration with pulse, no respiration without pulse groups was 15.4% (4/26), 21.7% (46/212), 14.7% (5/34), and 2.3% (143/6328), respectively. Interaction test for survival disclosed a significant interaction between respiration and pulsation (p = 0.002). Agonal breathing was strongly associated with shockable initial rhythm (OR; 95% CI, 3.73; 2.66-5.23) and neurologically favorable one-year survival (12.0; 8.3-17.3) only when pulse was absent on EMT arrival at patients (Table). The survival rate was extremely high [56.3% (27/48)] when initial rhythm was shockable and when agonal respiration was observed. Conclusions: Carotid pulse was present in some (11%) of OHCA patients with agonal respiration on ENT arrival at patients, indicating that chest compressions may be initiated before “true” cardiac arrest in adherence to current BLS guidelines. Agonal respiration was associated with neurologically favorable survival from OHCAs only when carotid pulse was absent on EMT arrival at patients.