tbuckley/cabot-search huggingface dataset:
AB0030 Persistence of Humoral and Cellular Immunity Against Tick-Borne-Encephalitis Vaccination in Patients with Juvenile Idiopathic Arthritis (JIA)
Authors: K. Robrade, R. Stern, G. Almanzar, M. Kleines, F. Speth, B. Hügle, J.P. Haas, M. Prelog
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Reduced immunogenicity and efficacy of vaccinations and waning of vaccine-antigen-specific immunity were reported for patients with rheumatic diseases with immunosuppressive therapy or biologics. So far, the persistence of the humoral and cellular immune response against tick-born-encephalitis-virus (TBEV) vaccine was not analyzed in immunocompromised patients with Juvenile Idiopathic Arthritis (JIA). <h3>Objectives</h3> Thus, the TBEV-specific humoral and cellular immunity was investigated in 64 patients with JIA and 38 age-matched healthy controls who had received at least three dosages of TBEV-vaccine in the past. <h3>Methods</h3> Antibody concentrations and avidities were measured by adapted ELISAs, TBEV-specific cellular reactivity by ELISPOT assays in spot forming units (SFUs) per 100.000 cells. <h3>Results</h3> Positive IgG-anti-TBEV antibody concentrations (&gt;165 VIEU/ml) were found in 59 JIA patients (92.2%) compared to 100% of healthy controls. Forty-one JIA patients (64.1%) had high antibody concentrations &gt;1000 VIEU/ml compared to 34 HC (89.5%). Relative avidity index (RAI) was high in JIA patients (82.9%). Significantly higher SFUs were seen in HC (mean 780 SFU) than in JIA (500 SFU). So far, no correlations between TBEV-specific antibody concentrations, avidities or SFU were found. <h3>Conclusions</h3> Although lower TBEV-specific antibody concentrations and SFU were demonstrated by JIA patients, a sufficient TBEV-specific humoral and cellular immune response was presented even several years after primary TBEV-vaccination in those patients. Whether TBEV-specific immunity may be influenced by age, therapeutic regimens and disease activity and will wane faster in JIA patients with need for earlier booster doses requires proof by longitudinal studies. <h3>Disclosure of Interest</h3> None declared
INCIDENCE AND CLINICAL IMPACT OF LONGITUDINAL STENT DEFORMATION AFTER THE PROMUS ELEMENT PLATINUM CHROMIUM-EVEROLIMUS ELUTING STENT IMPLANTATION
Authors: Takashi Hiromasa, Shoichi Kuramitsu, Takenori Domei, Makoto Hyodo, Shinichi Shirai, Kenji Ando, Masakiyo Nobuyoshi
Journal: Journal of the American College of Cardiology (2015)
SP0176 The TH-1/TH-17 Balance in JIA
Authors: L.R. Wedderburn
Journal: Annals of the Rheumatic Diseases (2015)

Th17 cells are known to be involved in the pathogenesis several autoimmune conditions including psoriasis and juvenile idiopathic arthritis, JIA. The blockade of IL-17 and or IL-23 are being increasingly considered as therapeutic options in autoimmune arthritis. In juvenile idiopathic arthritis (JIA) we have previously shown that the frequency of Th17 cells is correlated with severity of arthritis, and reciprocally related to the frequency to regulatory T cells (Treg) at the disease site. We have also shown that the lectin like receptor CD161 is expressed both on Th17 cells, but also on a subset of Th1 cells, and a proportion of Treg cells, in the joint. Th1 – like cells in the joints of patients with JIA include a large CD161+ population. Interestingly, Treg which express CD161, also make cytokines including IL-17 and IFNg. When synovial Th17 effector cells undergo plasticity in the joint, they convert to poly-functional cytokine producers, and these "ex-Th17" cells then produce GMCSF in addition to the typical Th1 cytokines. These cells retain their expression of CD161 on their surface. We have now undertaken an extensive molecular analysis of the CD161 +ve and – ve cell populations. In this talk we will consider the lineage, transcriptional and functional relationships between Treg, Th17 and Th1 cells in JIA and the translational implications of these findings. <h3>Disclosure of Interest</h3> None declared
The differential effects of chlordiazepoxide and oxazepam on hostility in a small group setting
Authors: G E Kochansky, C salzman, R I Shader, J S Harmatz, A M Ogeltree
Journal: American Journal of Psychiatry (1975)

The authors compared the effects of chlordiazepoxide, oxazepam, and placebo on hostility, as an inner motivational or arousal state, in moderately and highly anxious male research volunteers. The data again supported the hypothesis that clordiazepoxide-induced increases in motivational hostility are more frequent and intense than those associated with placebo and oxazepum. The data also suggest that oxazepam may be a more specific "hostility tranquilizer" than other benzodiazepines.
Olfactory identification deficits in HIV infection
Authors: D Brody, M Serby, N Etienne, D S Kalkstein
Journal: American Journal of Psychiatry (1991)

Impaired odor identification is described in a number of CNS disorders, and human immunodeficiency virus (HIV) infects the CNS in a large percentage of patients. To evaluate whether impaired olfaction may indicate CNS disease, the authors measured odor identification in patient groups defined along a continuum of progressive immunodeficiency and in a comparison group.Most of the 42 HIV-infected patients in the study were outpatients in a clinic specializing in treatment of HIV-infected individuals. The comparison subjects were 37 healthy age- and sex-matched individuals who were recruited from hospital and medical school personnel. Ten of the patients were HIV-seropositive but had no symptoms, 24 had clinical evidence of immunocompromise, and eight had HIV dementia. All subjects were given the University of Pennsylvania Smell Identification Test, which presents common odorants and requires the subject to identify the odor from a four-item word list. The data were analyzed by using analysis of variance after arc-sine transformation and Scheffé post hoc analysis.All patients scored significantly lower on the Smell Identification Test than did the comparison subjects. The patients with HIV dementia had significantly lower scores than did the other two groups of patients.Clinically, impaired olfaction might serve as a marker of early CNS HIV involvement. Future studies should attempt to match comparison and experimental populations for socioeconomic status and HIV risk behavior.
Locally acquired dengue - Key West, Florida, 2009-2010.
Authors: A. Trout, G. Baracco, M. Rodriguez, J. Barber, A. Leal, E. Radke, K. Weis, D. Stanek, L. Stark, C. Blackmore, G. Gallagher, E. Hunsperger, K. Tomashek, C. Gregory, E. Sauber-Schatz
Journal: MMWR Morbidity and Mortality Weekly Report (2010)
Dose-finding study of oral idarubicin and cyclophosphamide in first-line treatment of elderly patients with metastatic breast cancer
Authors: J.E. Kurtz, G. Deplanque, C. Borel, C. Mathelin, G. Prévost, G. Poulin, J.C. Barats, J.P. Bergerat, I. Chapelle-Marcillac, M. Bardonnet, P. Dufour
Journal: Annals of Oncology (2000)
Elevated plasma levels of neuropeptide Y in patients with panic disorder
Authors: J P Boulenger, I Jerabek, F B Jolicoeur, Y J Lavallée, R Leduc, A Cadieux
Journal: American Journal of Psychiatry (1996)

Neuropeptide Y is a pancreatic polypeptide closely associated with noradrenergic activity both in the central and peripheral nervous systems. The objective of this study was to assess plasma neuropeptide Y-like immunoreactivity in panic disorder.Radioimmunoassays were performed in 12 patients with DSM-III-R panic disorder and two groups of normal comparison subjects (N = 22 and N = 16).Markedly higher plasma neuropeptide Y-like immunoreactivity was found in patients with panic disorder.Higher plasma neuropeptide Y-like immunoreactivity suggests that this peptide may be implicated in the etiology or expression of symptoms of panic disorder.
PTH-212 High serum manganese levels in patients receiving long term total parenteral nutrition
Authors: S Nair, C Jeffray, C Mountford, NP Thompson
Journal: Gut (2015)

<h3>Introduction</h3> In patients receiving long term total parenteral nutrition (TPN), high manganese (Mn) levels have been associated with nervous system disorders including parkinsonism. T1-weighted magnetic resonance imaging in these patients demonstrates high intensity signals in the globus pallidus which regresses on discontinuation of the Mn supplementation. NICE guideline (CG32) recommends checking Mn levels in patients on long term TPN every 3–6 months. The aim of the study was to assess serum Mn levels in patients on long term TPN and to establish if withdrawing Mn supplementation results in normalisation of serum Mn levels. <h3>Method</h3> Serum Mn levels were measured in all patients receiving long term TPN in the North East of England and Cumbria during the study period from Nov 2013 to Jan 2015. Of those with a high serum Mn, supplementation was withdrawn and the levels were rechecked within 12 months of withdrawal. <h3>Results</h3> In the North East of England and Cumbria, 77 patients were receiving long term TPN during the study period. Of these, 48 were female and 29 were male. The age range of patients was from 19 to 84 years. The indication for TPN included; 23 ischaemia, 21 inflammatory bowel disease, 10 intra-abdominal malignancy, 9 post-surgical complication, 5 enteric dysmotility, 4 radiation enteritis, 3 visceral myopathy, 1 connective tissue disorder and 1 congenital abdominal defect. Of the 77 patients, 46 had high serum Mn levels at initial measurement (mean 288nmol/l; range 90–1620). Serum Mn levels were rechecked in these patients within 12 months of Mn withdrawal. When rechecked, 26 patients had normal serum Mn levels and 11 patients had a reduced Mn levels but above normal limits. 9 patients did not undergo a repeat Mn level due to either acute illness, discontinuation of TPN or death. No patients reported any neurological symptoms to suggest toxicity. <h3>Conclusion</h3> The study demonstrated that high levels of Mn are found in 60% of all patients receiving long term TPN. Withdrawing Mn supplementation in these patients results in a normalisation of Mn levels in 57% and a reduction in Mn level in 20% within 12 months. Although no patients in the study showed signs of Mn toxicity, studies have shown a potential risk resulting in neurological disorders. This study highlights the importance of checking Mn levels in keeping with NICE guidance every 3–6 months and adjusting Mn supplementation for those with high levels to avoid potential toxicity. Mn is supplemented in combination with other trace elements some of which may not be replaced individually including molybdenum, iodine and chromium. Further studies are required to determine the clinical significance of withdrawing these trace elements. <h3>Disclosure of interest</h3> None Declared.
Group calls for more to be done to tackle corruption in the pharmaceutical industry
Authors: Ingrid Torjesen
Journal: BMJ (2016)

Corruption is rife in the global pharmaceutical sector and governments need to do more to tackle it, a report from Transparency International, a global anti-corruption action group, has said.1

As of the beginning of 2016, one in 10 corruption investigations in the US has involved pharmaceutical companies, the report said—which is far higher than the number of cases that involve the banking sector.

The report also showed that nearly half of corruption cases investigated in the health sector related to sales and marketing; that good manufacturing practice standards were vulnerable to bribery and corruption because of a lack of enforced regulation; that many countries had few safeguards to prevent vital medicines disappearing during the …
Gastrointestinal stromal tumor of the colon – endoscopic treatment by full-thickness resection
Authors: Andreas Probst, Tina Schaller, Helmut Messmann
Journal: Endoscopy (2015)

A 51-year-old man was referred for therapy of a submucosal tumor of the sigmoid colon. The lesion had been diagnosed during screening colonoscopy, and biopsies had shown gastrointestinal stromal tumor (GIST). We confirmed a 15-mm submucosal tumor located in the proximal sigmoid colon ([Fig. 1]).
A Comparative Study of the Shope Fibroma in Rabbits in Relation to Transmissibility by Mosquitoes&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Herbert T. Dalmat, Mearl F. Stanton
Journal: JNCI Journal of the National Cancer Institute (1959)

A study of the Shope fibroma in cottontail rabbits, suckling domestic rabbits, and adult domestic rabbits revealed that the transmissibility of the fibroma by mosquitoes can be correlated with the histologic development of the lesion. The developing fibroma of the suckling domestic rabbits or of the cottontail rabbits generally became infective for mosquitoes when it reached a stage of maturity characterized by closely packed fibroma cells rich in cytoplasm containing inclusion bodies larger than 2 μ. The fibromas of adult domestic rabbits, induced by inoculating suspensions of fibroma tissue, regressed before reaching this mature stage and rarely were infective for mosquitoes. Fibromas that were infective for mosquitoes could be induced in the adult domestic rabbit by altering host-virus relationships through X irradiation or carcinogen treatment of the host, or passage of the virus through a foreign host. Such lesions became infective when prolongation of their development permitted maturation to a morphologic stage comparable to that seen in the mosquito-transmissible fibromas of suckling domestic rabbits and cottontail rabbits.
Diphtheria Toxin Fused to Granulocyte-Macrophage Colony-Stimulating Factor Eliminates Acute Myeloid Leukemia Cells With the Potential to Initiate Leukemia in Immunodeficient Mice, But Spares Normal Hemopoietic Stem Cells
Authors: Wim Terpstra, Henk Rozemuller, Dimitri A. Breems, Elwin J.C. Rombouts, Arie Prins, David J.P. FitzGerald, Robert J. Kreitman, Jenne J. Wielenga, Rob E. Ploemacher, Bob Löwenberg, Anton Hagenbeek, Anton C.M. Martens
Journal: Blood (1997)
AB0835 Association Between Sociodemographic and Clinical Features with Radiographic Severity in Knee Osteoarthritis – Results from Epireumapt
Authors: A.R. Sepriano, H. Canhão, A. Rodrigues, N. Gouveia, M. Eusébio, F. Pimentel-Santos, J.C. Branco
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To assess patient characteristics associated with radiographic severity in knee osteoarthritis (KOA) in a population-based study. <h3>Methods</h3> EpiReumaPt is a national epidemiologic, cross-sectional study of rheumatic diseases (RD) in the Portuguese population conducted from September 2011 to December 2013. From the 3877 patients assessed by a rheumatologist on the second phase of the study, we included all cases of KOA defined according to the American College of Rheumatology clinical and/or radiographic classification criteria. Knee x-rays were acquired using a standardized protocol and centrally scored according to the Kellgren-Lawrence (KL) scale. The knee osteoarthritis outcome score (KOOS) was used to assess KOA clinical features. Weighted stepwise multivariate logistic regression was used to assess which features associated with radiographic severity, after stratifying the disease in mild (grade 0 to 2) and severe (grade 3 and 4) KOA according to the KL scale. <h3>Results</h3> A total of 981 (weighted prevalence: 12.4%) patients were classified as KOA patients. Knee radiographs were available for 553 patients. From those, 318 (63.7%) had mild disease and 235 (36.3%) had severe disease. On the multivariate analysis, several patient9s features were significantly and independently associated to radiographic severity: age (OR: 1.08; p&lt;0.001), obesity (OR: 2.7; p=0.014); dyslipidemia (OR: 2.73; p=0.002), the total number of non-rheumatic comorbidities (OR: 0.63; p&lt;0.001); Country region (OR: 0.61; p&lt;0.001); orthopedic intervention of the knee (OR: 4.71; p=0.004); KOOS symptoms subscale (OR: 0.96; p=0.001; higher KOOS, less symptoms). Alentejo region had the higher proportion of severe disease [56.0% (36.2-75.7)], whereas Lisbon area had the lowest [36.4% (26.9-45.8)]. <h3>Conclusions</h3> We found several clinical and sociodemographic features associated with radiographic severity in KOA patients. Our findings contribute to the understanding of disease progression mediators. A longitudinal evaluation is needed to validate these results. <h3>Disclosure of Interest</h3> None declared
Chronic Myelogenous Leukemia Clinical Practice Guidelines in Oncology
Authors: Susan O'Brien
Journal: Journal of the National Comprehensive Cancer Network (2005)

Chronic myelogenous leukemia (CML) accounts for 15% of adult leukemias. In 2005, an estimated 4,600 cases will be diagnosed, and 850 patients will die of the disease. The median age of disease onset is 53 years; however, CML occurs in all age groups, with an increasing proportion of younger patients in more recent series. ML progresses from a chronic phase to a rapidly fatal blastic phase, generally over 3 to 5 years. The blast phase is often preceded by a transition period, called the accelerated phase, which is marked by the acquisition of new cytogenetic abnormalities in 50% to 80% of patients. Several definitions of the accelerated phase of the disease are summarized. For the most recent version of the guidelines, please visit NCCN.org
Nutcracker Esophagus
Authors: Luc Biedermann, Oliver Götze
Journal: New England Journal of Medicine (2013)

An 87-year-old woman with severe retrosternal pain and intermittent dysphagia was referred to the clinic for further evaluation. She described paroxysms of crampy pain almost exclusively during the intake of solid foods. In the past several months, she noted a weight loss of 5 kg. Endoscopy revealed a pronounced helical configuration of the esophageal lumen (Panel A and Video). Strong esophageal contractions occurred such that any advancement or withdrawal of the endoscope was hindered for several seconds. A barium swallow revealed a corkscrew appearance (Panel B). High-resolution manometry of the esophagus showed high-amplitude pressure waves, indicating a hypertensive peristaltic disorder . . .
The New NHS: A Guide
Authors: David J Hunter
Journal: BMJ (2006)

I t is said that if you're not confused by the workings of the NHS then you don't really understand it. Since the New Labour government was first elected in 1997, four major NHS “redisorganisations” have occurred, culminating in the changes currently weakening the service further and which are arguably the most far reaching in its history. Most worrying, the government is unleashing forces over which it has, at best, imperfect control. Neither it nor any of us knows where the changes will ultimately lead. We are engaged in a massive experiment with the only certainty being that, at no other time since its inception, has the future of the NHS been so uncertain. At the core of this uncertainty is that no clear narrative connects the government's changes, with the result that policy after policy has been spewed out with a cavalier disregard for their purpose and impact. Little wonder that confusion is rife among staff, patients, and public. Rating: ![Graphic][1]</img>![Graphic][2]</img>![Graphic][3]</img>![Graphic][4]</img> A … [1]: /embed/inline-graphic-1.gif [2]: /embed/inline-graphic-2.gif [3]: /embed/inline-graphic-3.gif [4]: /embed/inline-graphic-4.gif
P(VDF‐TrFE)/BaTiO<sub>3</sub> Nanoparticle Composite Films Mediate Piezoelectric Stimulation and Promote Differentiation of SH‐SY5Y Neuroblastoma Cells
Authors: Giada Graziana Genchi, Luca Ceseracciu, Attilio Marino, Massimiliano Labardi, Sergio Marras, Francesca Pignatelli, Luca Bruschini, Virgilio Mattoli, Gianni Ciofani
Journal: Advanced Healthcare Materials (2016)

Poly(vinylidene fluoride‐trifluoroethylene, P(VDF‐TrFE)) and P(VDF‐TrFE)/barium titanate nanoparticle (BTNP) films are prepared and tested as substrates for neuronal stimulation through direct piezoelectric effect. Films are characterized in terms of surface, mechanical, and piezoelectric features before in vitro testing on SH‐SY5Y cells. In particular, BTNPs significantly improve piezoelectric properties of the films (4.5‐fold increased d 31 ). Both kinds of films support good SH‐SY5Y viability and differentiation. Ultrasound (US) stimulation is proven to elicit Ca 2+ transients and to enhance differentiation in cells grown on the piezoelectric substrates. For the first time in the literature, this study demonstrates the suitability of polymer/ceramic composite films and US for neuronal stimulation through direct piezoelectric effect.
Solitary Pulmonary Metastasis of Choroidal Malignant Melanoma:
Authors: S. Harada, T. Kuwahara, M. Kido, A. Kajiki, Yoshiya Ishikura, Osamu Koide
Journal: Endoscopy (1983)

This brief report describes an unusual case of a patient who had a solitary pulmonary metastasis from an intraocular tumor removed 9 years previously. He was diagnosed by bronchofiberscopy and subjected to right middle lobectomy. Pathological examination revealed that the lesion resulted from direct metastasization to the bronchial wall.
Psychosocial rehabilitation and psychiatry in the care of long-term patients
Authors: L L Bachrach
Journal: American Journal of Psychiatry (1992)

The relationship between psychosocial rehabilitation and psychiatry in the care of long-term mental patients is one that may often be characterized, at best, as an uneasy alliance. The author summarizes the basic concepts that define the discipline of psychosocial rehabilitation and discusses how those concepts have at times been distorted in actual practice. The article concludes with an analysis of the two disciplines' common ground in caring for long-term patients and a commentary on the benefits that each may offer the other. Together psychiatry and psychosocial rehabilitation hold the key to improved circumstances for realizing the promise of deinstitutionalization, which seems largely to have eluded us for the past several decades.
CD44 SNPrs187115: A Novel Biomarker Signature that Predicts Survival in Resectable Pancreatic Ductal Adenocarcinoma
Authors: Giovanni Stracquadanio, Bart Vrugt, Renata Flury, Peter Schraml, Peter Würl, Thomas H. Müller, Uwe Knippschild, Doris Henne-Bruns, Stefan Breitenstein, Pierre-Alain Clavien, Rolf Graf, Gareth L. Bond, Lukasz F. Grochola
Journal: Clinical Cancer Research (2016)

Although pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor, like other common cancers, it displays a wide range of biology. However, at present, there are no reliable tests to predict patients' cancer-specific outcomes and guide personalized treatment decisions. In this study, we aim to identify such biomarkers in resectable PDAC by studying SNPs in the CD44 gene, which drives the progression of pancreatic cancer.A total of 348 PDAC patients from three independent cohorts [Switzerland, Germany, The Cancer Genome Atlas (TCGA)] who underwent pancreatic resection are included in the study. Information on the haplotype structure of the CD44 gene is obtained using 1000 Genomes Project data, and the genotypes of the respective tagging SNPs are determined. Cox proportional hazards models are utilized to analyze the impact of SNP genotype on patients' survival.We identify an SNP in the CD44 gene (SNPrs187115) that independently associates with allelic differences in prognosis in all study cohorts. Specifically, in 121 Swiss patients, we observe an up to 2.38-fold (P = 0.020) difference in tumor-related death between the genotypes of SNPrs187115 We validate those results in both the German (HR = 2.32, P = 0.044, 101 patients) and the TCGA cohort (HR = 2.36, P = 0.044, 126 patients).CD44 SNPrs187115 can serve as a novel biomarker readily available at the time of PDAC diagnosis that identifies patients at risk for faster tumor progression and guide personalized treatment decisions. It has the potential to significantly expand the pool of patients that would benefit from tumor resection. Clin Cancer Res; 22(24); 6069-77. ©2016 AACR.