Update in Critical Care Medicine: Evidence Published in 2015
Authors: Nathan E. Brummel, E. Wesley Ely
Journal: Annals of Internal Medicine (2016)

Updates3 May 2016Update in Critical Care Medicine: Evidence Published in 2015Nathan E. Brummel, MD, MSCI and E. Wesley Ely, MD, MPHNathan E. Brummel, MD, MSCIFrom Vanderbilt University School of Medicine and Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, and Geriatric Research, Education and Clinical Center, Nashville, Tennessee.Search for more papers by this author and E. Wesley Ely, MD, MPHFrom Vanderbilt University School of Medicine and Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, and Geriatric Research, Education and Clinical Center, Nashville, Tennessee.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M16-0572 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail This update summarizes key articles in critical care medicine published in 2015. We selected them based on their novelty, publication in high-impact journals, relevance to clinicians in internal medicine, and effects on clinical practice. Studies in patients with sepsis demonstrated the lack of effect of early goal-directed resuscitation in a modern cohort and provided insight into the use of the systemic inflammatory response syndrome (SIRS) criteria to identify patients with sepsis in the intensive care unit (ICU) and on hospital wards. A novel association between pneumonia and an increased risk for cardiovascular disease was identified. Investigators also found a survival ...References1. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al; Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2012. Crit Care Med. 2013;41:580-637. [PMID: 23353941] doi:10.1097/CCM.0b013e31827e83af CrossrefMedlineGoogle Scholar2. Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, et al; ARISE Investigators. Goal-directed resuscitation for patients with early septic shock. N Engl J Med. 2014;371:1496-506. [PMID: 25272316] doi:10.1056/NEJMoa1404380 CrossrefMedlineGoogle Scholar3. Yealy DM, Kellum JA, Huang DT, Barnato AE, Weissfeld LA, Pike F, et al; ProCESS Investigators. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014;370:1683-93. [PMID: 24635773] doi:10.1056/NEJMoa1401602 CrossrefMedlineGoogle Scholar4. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, et al; SCCM/ESICM/ACCP/ATS/SIS. 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med. 2003;31:1250-6. [PMID: 12682500] CrossrefMedlineGoogle Scholar5. Seymour CW, Liu VX, Iwashyna TJ, Brunkhorst FM, Rea TD, Scherag A, et al. Assessment of clinical criteria for sepsis: for the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:762-74. [PMID: 26903335] doi:10.1001/jama.2016.0288 CrossrefMedlineGoogle Scholar6. Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315:801-10. [PMID: 26903338] doi:10.1001/jama.2016.0287 CrossrefMedlineGoogle Scholar7. Climo MW, Yokoe DS, Warren DK, Perl TM, Bolon M, Herwaldt LA, et al. Effect of daily chlorhexidine bathing on hospital-acquired infection. N Engl J Med. 2013;368:533-42. [PMID: 23388005] doi:10.1056/NEJMoa1113849 CrossrefMedlineGoogle Scholar8. Kahn JM, Benson NM, Appleby D, Carson SS, Iwashyna TJ. Long-term acute care hospital utilization after critical illness. JAMA. 2010;303:2253-9. [PMID: 20530778] doi:10.1001/jama.2010.761 CrossrefMedlineGoogle Scholar9. Kahn JM, Le T, Angus DC, Cox CE, Hough CL, White DB, et al; ProVent Study Group Investigators. The epidemiology of chronic critical illness in the United States. Crit Care Med. 2015;43:282-7. [PMID: 25377018] doi:10.1097/CCM.0000000000000710 CrossrefMedlineGoogle Scholar10. Unroe M, Kahn JM, Carson SS, Govert JA, Martinu T, Sathy SJ, et al. One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med. 2010;153:167-75. [PMID: 20679561]. doi:10.7326/0003-4819-153-3-201008030-00007 LinkGoogle Scholar11. Nelson JE, Cox CE, Hope AA, Carson SS. Chronic critical illness. Am J Respir Crit Care Med. 2010;182:446-54. [PMID: 20448093] doi:10.1164/rccm.201002-0210CI CrossrefMedlineGoogle Scholar12. Carson SS, Kahn JM, Hough CL, Seeley EJ, White DB, Douglas IS, et al; ProVent Investigators. A multicenter mortality prediction model for patients receiving prolonged mechanical ventilation. Crit Care Med. 2012;40:1171-6. [PMID: 22080643] doi:10.1097/CCM.0b013e3182387d43 CrossrefMedlineGoogle Scholar13. Hough CL, Caldwell ES, Cox CE, Douglas IS, Kahn JM, White DB, et al; ProVent Investigators and the National Heart Lung and Blood Institutes Acute Respiratory Distress Syndrome Network. Development and validation of a mortality prediction model for patients receiving 14 days of mechanical ventilation. Crit Care Med. 2015;43:2339-45. [PMID: 26247337] doi:10.1097/CCM.0000000000001205 CrossrefMedlineGoogle Scholar14. Aslakson RA, Curtis JR, Nelson JE. The changing role of palliative care in the ICU. Crit Care Med. 2014;42:2418-28. [PMID: 25167087] doi:10.1097/CCM.0000000000000573 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Vanderbilt University School of Medicine and Department of Veterans Affairs Medical Center, Tennessee Valley Healthcare System, and Geriatric Research, Education and Clinical Center, Nashville, Tennessee.Disclaimer: The contents of this paper are solely the responsibility of the authors and do not necessarily represent those of the U.S. government, the U.S. Department of Veterans Affairs, the National Institutes of Health, or Vanderbilt University.Grant Support: From the National Institutes of Health (awards KL2TR000446, R03AG040549, R01AG035117 and R01HL111111), Department of Veterans Affairs Tennessee Valley Health Care System Geriatric Research, Education and Clinical Center (GRECC). These funding sources had no role in the design and conduct of the study; collection, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.Disclosures: Dr. Brummel reports grants from National Institutes of Health during the conduct of the study. Dr. Ely reports grants from National Institutes of Health and other support from Department of Veterans Affairs, Tennessee Valley Healthcare System GRECC during the conduct of the study, as well as other support from Abbott, Pfizer, Orion, Hospira outside the submitted work. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-0572.Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that she has no financial relationships or interests to disclose. Darren B. Taichman, MD, PhD, Executive Deputy Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Deborah Cotton, MD, MPH, Deputy Editor, reports that she has no financial relationships or interest to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Catharine B. Stack, PhD, MS, Deputy Editor for Statistics, reports that she has stock holdings in Pfizer and Johnson & Johnson.Corresponding Author: Nathan E. Brummel, MD, MSCI, Vanderbilt University School of Medicine, Suite 350, 2525 West End Avenue, Nashville, TN 37203; e-mail, nathan.[email protected]edu.Current Author Addresses: Dr. Brummel: Vanderbilt University School of Medicine, Suite 350, 2525 West End Avenue, Nashville, TN 37203.Dr. Ely: VA Tennesse Valley Healthcare System Geriatric Research, Education and Clinical Center (GRECC), and Department of Medicine, Vanderbilt School of Medicine, Nashville, TN 37232-8300.Author Contributions: Conception and design: N. Brummel, E.W. Ely.Analysis and interpretation of the data: N. Brummel, E.W. Ely.Drafting of the article: N. Brummel, E.W. Ely.Critical revision for important intellectual content: N. Brummel, E.W. Ely.Final approval of the article: N. Brummel, E.W. Ely.Obtaining of funding: N. Brummel, E.W. Ely.Collection and assembly of data: N. Brummel, E.W. Ely. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 3 May 2016Volume 164, Issue 9Page: W15-W20KeywordsBlood transfusionCardiovascular diseasesHospitalizationsIntensive care unitsMortalityPneumoniaSepsisShockTracheostomyVentilators ePublished: 3 May 2016 Issue Published: 3 May 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...