tbuckley/cabot-search huggingface dataset:
The Impact of Allogeneic Hematopoietic Stem Cell Transplantation in Children and Adolescents with Recurring Hodgkin’s Lymphoma: An EBMT Study on 151 Patients.
Authors: Alexander Claviez, Carmen Canals, Marc Boogaerts, Jerry Stein, Stephen Mackinnon, Rodrigo Martino, Andrea Pession, Shimon Slavin, Charles Craddock, Ioanna Sakellari, Paolo Corradini, Alessandro Rambaldi, Meinolf Suttorp, Giorgio Dini, Anna Sureda, Norbert Schmitz
Journal: Blood (2007)
The HDAC INHIBITOR ITF2357 MODULATES KEY HEMATOPOIETIC GENES in JAK2V617F CELLS From MYELOPROLIFERATIVE Neoplasm PATIENTS
Authors: Ariel Amaru, Katia Todoerti, Anna Pellicioli, Luca Donadoni, Giacomo Tuana, Olga Pedrini, Guido Finazzi, Antonino Neri, Gianluca Fossati, Alessandro Rambaldi, Martino Introna, Luigia Lombardi, Josée Golay
Journal: Blood (2010)
Two-step two-stent technique to manage a large gastrocolonic fistula
Authors: Diogo Libânio, Jorge Lage, Sara Pires, Rui Silva, Mário Dinis-Ribeiro
Journal: Endoscopy (2017)

Gastrocolonic malignant fistulas can occur, although rarely, complicating gastric or colonic neoplasms. En bloc resection of the fistulous tract and involved segments is the first-line treatment whenever possible, with endoscopic treatment an alternative. Endoscopic closure has been described using covered stents [1] [2], over-the-scope clips [3], and atrial septal defect occlusion devices [4]. However, in the colon, covered stents are associated with a high migration risk [5].
Concomitant, T-Independent TLR9-Mediated and BCR-Mediated Activation Provides Signals For Optimal Telomerase Induction In Chronic Lymphocytic Leukemia Cells Regardless Of IGHV Mutation Status
Authors: Rajendra N Damle, Sonal Temburni, Ryon M. Andersen, Jacqueline C. Barrientos, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Nicholas Chiorazzi
Journal: Blood (2013)
Studies on the Pulmonary Diffusing Capacity and the Pulmonary Circulation with Special Reference to the Haemodynamic Aspects of the Average Contact Time : Symposium on Intravascular Catheterization
Authors: Tetsuro Yokoyama, Kazuhiko Katayama
Journal: Circulation (1963)

1) The method of estimating the average contact time through simultaneous measurements on the red cell component of the apparent pulmonary diffusing capacity and the effective pulmonary blood flow. 2) The physiological basis of the present method was introduced. 3) The average contact time in cases of normal healthy was ranged between 0.3-0.5 sec and that in cases of any cardiopulmonary diseases had revealed various degree of restriction. 4) The average contact time has been studied in relation with any haemodynamic factors of the pulmonary circulation and some physiological significance of the average contact time was reported. 5) As for the cause of the restriction of the average contact time, the authors have pointed out the following items : such as a) increase in cardiac output, b) decrease in effective pulmonary capillary beds, c) decrease in pulmonary blood volume, etc. 6) The importance and necessity of further investigations to give any definite conclusion on the physiological mechanism to cause any restriction of the average contact time was emphasized.
Co-option and <i>de novo</i> gene evolution underlie molluscan shell diversity
Authors: Felipe Aguilera, Carmel McDougall, Bernard M. Degnan
Journal: Molecular Biology and Evolution (2016)

Molluscs fabricate shells of incredible diversity and complexity by localized secretions from the dorsal epithelium of the mantle. Although distantly related molluscs express remarkably different secreted gene products, it remains unclear if the evolution of shell structure and pattern is underpinned by the differential co-option of conserved genes or the integration of lineage-specific genes into the mantle regulatory program. To address this, we compare the mantle transcriptomes of 11 bivalves and gastropods of varying relatedness. We find that each species, including four Pinctada (pearl oyster) species that diverged within the last 20 Ma, expresses a unique mantle secretome. Lineage- or species-specific genes comprise a large proportion of each species' mantle secretome. A majority of these secreted proteins have unique domain architectures that include repetitive, low complexity domains (RLCDs), which evolve rapidly, and have a proclivity to expand, contract and rearrange in the genome. There are also a large number of secretome genes expressed in the mantle that arose before the origin of gastropods and bivalves. Each species expresses a unique set of these more ancient genes consistent with their independent co-option into these mantle gene regulatory networks. From this analysis, we infer lineage-specific secretomes underlie shell diversity, and include both rapidly evolving RLCD-containing proteins, and the continual recruitment and loss of both ancient and recently evolved genes into the periphery of the regulatory network controlling gene expression in the mantle epithelium.
S24 A comparison of pulse transit time between subjects with obstructive sleep apnoea syndrome, nocturnal inspiratory flow limitation and the absence of significant sleep disordered breathing
Authors: B Chakrabarti, S Emegbo, S Craig, N Duffy, JF O’Reilly
Journal: Thorax (2016)

<h3>Introduction</h3> Pulse Transit Time (PTT) represents a non-invasive indirect marker of sleep fragmentation in OSAS. Little is known regarding PTT indices in persons presenting with sleepiness where sleep studies exhibit “flow limited” breaths in the absence of clinically significant OSA (a so called Inspiratory “Flow Limitation” (IFL) cohort) and whether PTT indices differ when compared to OSAS subjects and with a “control” group exhibiting no evidence of OSAS or IFL (“Non-Flow Limited” or NFL cohort). <h3>Methodology</h3> 20 subjects meeting criteria for the IFL cohort (mean AHI = 3.84/hr; RDI = 17.71/hr) were aged (± 2 yrs) and gender matched with 20 OSAS subjects (mean AHI = 48.93 hr) and 20 control “NFL” subjects (no sleep disordered breathing; mean AHI = 1.01/hr; RDI = 2.63/hr) underwent respiratory limited polysomnography, including pulse oximetry and ECG monitoring. PTT was defined as interval between the electrocardiographic R wave and point corresponding to 50% height of the ascending plethysmographic (pulse) waveform; PTT arousal (deceleration) defined by decline in PTT signal of ≥15 ms, lasting 5 seconds; PTT Deceleration index (PTT Di) defined by number of PTT arousals per hour. <h3>Results</h3> Table 1 outlines key demographics in the cohorts. Of the NFL cohort, 14 presented with snoring in absence of sleepiness. 72% and 84% were deemed “responders” to CPAP within the IFL and OSAS cohorts respectively. The PTT DI in the IFL cohort (33.67 ± (23.34)/hr) was significantly higher than that measured in the control NFL cohort (23.89 ± (18.88)/hr) but significantly lower than that measured in the OSAS cohort (55.21 ± (29.30)/hr; 3-way ANOVA; F = 8.76; p &lt; 0.001). PTT Di was positively correlated with AHI within the whole study population (CC = 0.46; p &lt; 0.001). Within the IFL cohort, PTT Di was positively correlated with age (CC = 0.501; p = 0.024) but not with gender and BMI. <h3>Conclusion</h3> The PTT Deceleration Index increased proportionately with SDB, with significantly higher markers of arousal in sleepy subjects exhibiting nocturnal IFL in comparison to control subjects, but not as high as those with clinically significant OSA. These findings support the relevance of IFL as a potentially significant pathogenic entity in the development of daytime sleepiness. The utility of PTT Deceleration Index as a therapeutic target for CPAP Titration in OSAS requires further evaluation.
Increased prevalence of coronary plaque in patients with psoriatic arthritis without prior diagnosis of coronary artery disease
Authors: Jiayun Shen, Ka-Tak Wong, Isaac T Cheng, Qing Shang, Edmund K Li, Priscilla Wong, Emily W Kun, Mei Yan Law, Ronald Yip, Isaac Yim, Shirley Ying, Martin Li, Tena K Li, Chun-Kwok Wong, Tracy Y Zhu, Jack Jock-Wai Lee, Mimi Chang, Alex Pui-Wai Lee, Lai-Shan Tam
Journal: Annals of the Rheumatic Diseases (2017)

To evaluate coronary atherosclerosis in patients with psoriatic arthritis (PsA) and control subjects using coronary CT angiography (CCTA).Ninety consecutive patients with PsA (male: 56(62.2%); 50.3±11.1 years) were recruited. 240 controls (male: 137(57.1%); 49.6±10.7 years) without known cardiovascular (CV) diseases who underwent CCTA due to chest pain and/or multiple CV risk factors were recruited for comparison.Patients with PsA and controls were matched in age, gender and traditional CV risk factors (all p>0.2). The prevalence of overall plaque (54(60%)/84(35%), p<0.001), calcified plaque (CP) (29(32%)/40(17%), p=0.002), mixed plaque (MP) (20(22%)/18(8%), p<0.001), non-calcified plaque (NCP) (39(43%)/53(22%), p<0.001) and combined MP/NCP (46(51%)/62(26%), p<0.001) were all significantly higher in patients with PsA. Three-vessel disease was diagnosed in 12(13%) patients with PsA and 7(3%) controls (p<0.001), while obstructive plaques (>50% stenosis) were observed in 8(9%) patients with PsA and 7(3%) controls (p=0.033). After adjusting for traditional CV risk factors, PsA remained an independent explanatory variable for all types of coronary plaques (OR: 2.730 to 4.064, all p<0.001). PsA was also an independent explanatory variable for three-vessel disease (OR: 10.798, p<0.001) and obstructive plaque (3.939, p=0.024). In patients with PsA, disease duration was the only disease-specific characteristic associated with more vulnerable plaques (MP/NCP) in multivariate analysis (1.063, p=0.031). The other independent explanatory variables were age ≥55 years (5.636, p=0.005) and male gender (8.197, p=0.001).Patients with PsA have increased prevalence, burden and severity of coronary atherosclerosis as documented by CCTA. Longer disease duration was independently associated with the presence of vulnerable MP/NCP plaques in patients with PsA.NCT02232321.
MA15.05 PD-L1 Immunohistochemistry as Biomarker in Non-Small Cell Lung Cancer (NSCLC)
Authors: Dagmar Krenbek, Barbara Weidinger, Christa Jarius, Sophia Holzer, Hannah Fabican, Andrea Mohn-Staudner, Maximilian Hochmair, Andreas Chott, Ulrike Setinek
Journal: Journal of Thoracic Oncology (2017)
Abstract A23: Novel approach for targeting hepatocellular carcinoma cell survival: OSU-2S/Sorafenib combination
Authors: Hany A. Omar, Mai F. Tolba, Jui-Hsiang Hung, Taleb H. Al-Tel
Journal: Clinical Cancer Research (2017)

Abstract Background: OSU-2S is a novel non-immunosuppressant anticancer agent that was designed and developed using fingolimod (Gilenya®) as a scaffold. OSU-2S was reported to have a substantial anticancer activity against hepatocellular carcinoma (HCC) through different mechanisms. The effectiveness of HCC treatment is often poor due to acquired resistance during the course of therapy. The current work was aimed to test the possible therapeutic synergy between OSU-2S and sorafenib, the multi-kinase inhibitor which is used as standard first-line systemic treatment for advanced HCC. Mechanistically, such combination can achieve optimal anticancer activity through synergistic targeting of the cancer cell survival signaling pathways. Methods: The synergistic combination between OSU-2S and sorafenib was tested on three different HCC cell lines (Hep3B, Huh-7, HepG2) using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium) assay, colony formation, invasion, migration, immunofluorescence, and Western blot analysis. Results: The combination incidences for OSU-2S/ Sorafenib obtained from MTT and colony formation assays were in the range of 0.4-0.8 at different dose levels which indicated synergistic anticancer activity. This synergy was confirmed by enhanced ability to activate apoptosis and to hinder several cell survival signaling pathways such as mitogen-activated protein kinase (MAPK) pathway. The synergy was mediated through the activation of the pro-apoptotic kinase, PKCδ and the augmentation of reactive oxygen species generation. Conclusion: OSU-2S/ Sorafenib combination represents a novel therapeutically relevant approach to be introduced in HCC chemotherapeutic protocols which should effectively target cancer cells and improve the survival of HCC patients. Citation Format: Hany A. Omar, Mai F. Tolba, Jui-Hsiang Hung, Taleb H. Al-Tel. Novel approach for targeting hepatocellular carcinoma cell survival: OSU-2S/Sorafenib combination. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr A23.
P3.06-002 ATLANTIS Trial: Phase III Study of PM01183/Doxorubicin vs. CAV or Topotecan in SCLC after One Platinum-Containing Line
Authors: Anna Farago, Martin Forster, Luis Paz-Ares, Carmen Puparelli, Sergio Szyldergemajn, Jose Lopez-Vilarino, Keren Moss, Carmen Kahatt, Arturo Soto-Matos, Maria Eugenia Olmedo
Journal: Journal of Thoracic Oncology (2017)
Incorrect Figure Alignment and Error in Figure Legend
Authors: Young Lim, Keith Choate
Journal: JAMA Dermatology (2017)

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P2.08-007 Listen Advocate Voice - Web-Survey for the Japanese Model of Lung Cancer Advocacy by Society
Authors: Toshiyuki Sawa, Yoichi Nakanishi, Kazuhiko Nakagawa, Makoto Suzuki, Yuichi Takiguchi, Takashi Seto, Tetsuya Mitsudomi
Journal: Journal of Thoracic Oncology (2017)
P2.03a-048 The CDK4/6 Inhibitor G1T28 Protects Immune Cells from Cisplatin-Induced Toxicity in vivo and Inhibits SCLC Tumor Growth
Authors: Irene Guijarro, Alissa Poteete, Renata Ferrarotto, Warren Denning, Haifa Hamdi, Patrick Roberts, Rajesh Malik, John Bisi, Jessica Sorrentino, Jay Strum, Emily Roarty, John Heymach
Journal: Journal of Thoracic Oncology (2017)
P3.02b-003 Second-Line Afatinib versus Erlotinib for Patients with Squamous Cell Carcinoma of the Lung (LUX-Lung 8): Analysis of Tumor and Serum Biomarkers
Authors: Enriqueta Felip, Jean-Charles Soria, Manuel Cobo, Shun Lu, Kostas Syrigos, Ki Hyeong Lee, Erdem Göker, Vassilis Georgoulias, Wei Li, Salih Guclu, Dolores Isla, Young Joo Min, Alessandro Morabito, Andrea Ardizzoni, Shirish Gadgeel, Nicholas Dupuis, Neil Gibson, Nicole Krämer, Claudia Bühnemann, Flavio Solca, Eva Ehrnrooth, Glenwood Goss
Journal: Journal of Thoracic Oncology (2017)
The Efficacy and Safety of Lenalidomide Oral Monotherapy in Patients with Mantle Cell Lymphoma Previously Treated with Bortezomib: Pooled Data from Two Phase II Studies (NHL-002 and NHL-003).
Authors: Craig B. Reeder, T.E. Witzig, Julie M. Vose, Pier Luigi Zinzani, Rena Buckstein, Corinne Haioun, Reda Bouabdallah, Jonathan Polikoff, Pingshan Guo, Annette Ervin-Haynes, Dennis Pietronigro, Jerome B. Zeldis, Myron S. Czuczman
Journal: Blood (2008)
Unrelated Cord Blood Transplantation: Comparison After Single Unit Cord Blood Intrabone Injection and Double Unit Cord Blood Transplantation In Patients with Hematological Malignant Disorders. A Eurocord-EBMT Analysis
Authors: Vanderson Rocha, Myriam Labopin, Annalisa Ruggeri, Marina Podestà, Dolores Caballero, Francesca Bonifazi, Rovira Montserrat, Andrea Gallamini, Franca Fagioli, Gérard Socié, E. Nikiforakis, Mauricette Michallet, Eric Deconinck, Mohamad Mohty, Andrea Bacigalupo, Eliane Gluckman, Francesco Frassoni
Journal: Blood (2010)
The Deposition of H3.3 Mediated by Transcription Factors Determines Hematopoietic Cell Fate
Authors: Jun Odawara, Kohta Miyawaki, Kentaro Kohno, Takahiro Shima, Kazumitsu Maehara, Akihito Harada, Masayasu Hayashi, Masao Nagasaki, Yasuyuki Ohkawa, Koichi Akashi
Journal: Blood (2012)
Giant cell arteritis, infections and biologics
Authors: Sergey Moiseev, Pavel Novikov, Ilya Smitienko, Elena Shchegoleva
Journal: Annals of the Rheumatic Diseases (2017)

To the editor,

Numerous infectious agents have been implicated in the aetiology and/or pathogenesis of systemic vasculitides through direct damage of the vessel wall or autoimmune disorders. Mechanisms by which pathogens cause autoimmunity may include molecular mimicry (cross-reactivity between pathogen-derived and self-derived epitopes), epitope spreading (the immune response to a persisting pathogen), bystander activation (non-specific activation of autoimmune cells by the inflammatory environment during infection) or immune response to cryptic antigens (subdominant epitopes which are normally hidden from T-cell recognition).1 The causative role of infectious agents is clearly established in polyarteritis nodosa and cryoglobulinemic vasculitis that are commonly associated with hepatitis B virus and hepatitis C virus (HCV), respectively. Microbial pathogens may probably contribute to the development of other systemic vasculitides as well. However, the evidence for a definitive link between infection and induced autoimmunity in many vasculitides is less strong or lacking. Epidemiological studies showing an increased incidence of systemic vasculitis in people infected with a particular agent, while not wholly definitive, may strengthen the infection-induced autoimmunity concept.1 

In the impressive nested case–control study recently published in the Annals of the Rheumatic Diseases, 2 Rhee et al examined the relationship between any infection or herpes zoster infection and the development of giant cell arteritis (GCA) in a large cohort of patients (n=4559) and controls …
P180 Impact of the london low emission zone on children’s respiratory health: a sequential yearly cross sectional study 2008–2014
Authors: CJ Griffiths, I Mudway, H Wood, N Marlin, I Dundas, R Walton, J Grigg, A Sheikh, T Lee, F Kelly
Journal: Thorax (2016)

<h3>Background</h3> Low Emission Zones are a novel public health intervention to address the adverse effects of traffic pollution on health. We investigated the association between traffic derived air pollutants and lung function in 8–9 year old children living in London’s Low Emission Zone. <h3>Methods</h3> Sequential yearly cross-sectional study of 2,297 children aged 8–9 years attending east London primary schools between 2009 and 2014, following the introduction of the Low Emission Zone. We examined the relationship between pollutant exposures (NOx, NO2, PM2.5 and PM10) and lung function. We assigned annual exposures by each child’s residential address. In addition, we used spatially resolved estimates of 12-hour, 24-hour, 7-day and annual exposures prior to each child’s assessment, allowing us to compare the relative effects of very short-, short-, medium- and long-term pollutant exposures. Primary outcome measure was post-bronchodilator FEV1. <h3>Findings</h3> We found inverse associations between exposures of PM10 and PM2.5 in the week prior to children’s assessment and FEV1 (P &lt; 0.05); and inverse associations between annual exposures of PM10, NOx, and NO2, and FVC (p &lt; 0.05); and exposures of PM10 and PM2.5 in the week prior to assessment, and FVC (p &lt; 0.05). No associations were seen when shorter term exposure estimates were employed. We found no evidence of improvements in lung function over the duration of the Low Emission Zone. <h3>Interpretation</h3> Exposure of children to traffic pollution in central London is associated with decreased lung function and lung volumes. No detectable health benefit followed the introduction of the Low Emission Zone.
P3.04-038 Pulmonary Resection for Metastatic Pancreaticobiliary Cancer: Can It Be Justified as a Treatment of Choice?
Authors: Toshiki Okasaka, Koji Kawaguchi, Takayuki Fukui, Koichi Fukumoto, Shota Nakamura, Shuhei Hakiri, Naoki Ozeki, Akira Naomi, Tomoshi Sugiyama, Kohei Yokoi
Journal: Journal of Thoracic Oncology (2017)
Effects of Single-Agent, Low Dose Exogenous Erythropoietin In a Long-Term In Vitro serum-Free 3D Culture of Human Cord Blood Mononuclear Cells for Directed Erythropoiesis
Authors: Teresa Mortera Blanco, Athanasios Mantalaris, Joseph Santiapillai, Alexander Bismarck, Nicki Panoskaltsis
Journal: Blood (2010)
P3.01-022 Impact of Histologic Subtype and Spread through Air Spaces (STAS) in Stage III (N2) Lung Adenocarcinoma
Authors: Yuriko Terada, Jun-Ichi Nitadori, Shigeki Morita, Hideki Kuwano, Kazuhiro Nagayama, Masaki Anraku, Masaaki Sato, Aya Shinozaki-Ushiku, Masashi Fukayama, Jun Nakajima
Journal: Journal of Thoracic Oncology (2017)
Anterior T-Wave Inversion in Young White Athletes and Nonathletes
Authors: Aneil Malhotra, Harshil Dhutia, Sabiha Gati, Tee-Joo Yeo, Helder Dores, Rachel Bastiaenen, Rajay Narain, Ahmed Merghani, Gherardo Finocchiaro, Nabeel Sheikh, Alexandros Steriotis, Abbas Zaidi, Lynne Millar, Elijah Behr, Maite Tome, Michael Papadakis, Sanjay Sharma
Journal: Journal of the American College of Cardiology (2017)