tbuckley/cabot-search huggingface dataset:
AB0279 Periodontal Disease and Rheumatoid Arthritis – Comparison of Two Assessment Tools, and Their Value in The Determination of The Association between The Two Diseases
Authors: M. Bocskai, Z. Zalai, M. Antal, G. Braunitzer, L. Kovács
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Periodontitis is involved in the pathogenesis of rheumatoid arthritis (RA), and a worse periodontal status has been proposed to correlate with the inflammatory activity of RA and to have an impact on its responsiveness to therapy. Human studies have been hampered by the lack of well-standardized assessment tools of the severity of periodontal disease (PD). <h3>Objectives</h3> The authors9 aim was to compare the accuracy of two scoring systems of PD in RA patients, and to correlate the findings with multiple variables of RA activity and severity. <h3>Methods</h3> Eighty-one RA patients (mean age: 57 years, range: 28–82) were consecutively recruited. Disease activity was measured with DAS28, ESR, CRP, and swolllen and tender joint counts. Disease severity was assessed by the health assessment questionnaire (HAQ), anti-citrullinated peptide (mutated citrullinated vimentin) antibody and rheumatoid factor titers, and average DAS28 and average corticosteroid dose in the preceding year. The scoring of the severity of PD was assessed by means of the Community Periodontal Index of Treatment Needs (CPI) and the periodontal status classification, proposed by Fernandes et al. CPI scores PD severity on a 0–4 scale according to the presence of calculus and bleeding on probing (BOP) and probing depth, whereas the other index categorizes the severity as healthy-early-moderate-severe on the basis of clinical attachment level (CAL) and probing depth. Smoking status was also recorded. <h3>Results</h3> RA patients had a median score of 3 on the CPI index, and the median severity was moderate according to the periodontal status scale. The two systems had excellent correlation (Spearman r=0,966, p&lt;0.0001), and there was also a negative correlation between the number of teeth and the CPI score (r=0,254, p&lt;0.05) and the periodontal status score (r=0,210, p=0.059). A worse periodontal status (assessed with higher CPI score) was associated with a higher average DAS28 (despite therapy) measured during the year before the dental examination (r=0,376, p=0,022), with smoking (Kruskal-Wallis: p=0.014), and with higher DAS28 at the time of the examination (r=0.198, p=0.07). When assessed with the 4 staged periodontal status score, the association between PD severity and current DAS28 was significant (r=0.409, p=0.01). <h3>Conclusions</h3> CPI seems to have better performance than the periodontal status score proposed by Fernandes et al for the examination of the severity of PD in RA patients, and confirms the correlation between the severity of PD and RA activity and severity. This method is recommended for the research on the impact of periodontal status and of its correction on RA outcome. <h3>Disclosure of Interest</h3> None declared
MIF-Induced Stromal PKCβ/IL8 Is Essential in Human Acute Myeloid Leukemia
Authors: Amina M. Abdul-Aziz, Manar S. Shafat, Tarang K. Mehta, Federica Di Palma, Matthew J. Lawes, Stuart A. Rushworth, Kristian M. Bowles
Journal: Cancer Research (2016)

Acute myeloid leukemia (AML) cells exhibit a high level of spontaneous apoptosis when cultured in vitro but have a prolonged survival time in vivo, indicating that tissue microenvironment plays a critical role in promoting AML cell survival. In vitro studies have shown that bone marrow mesenchymal stromal cells (BM-MSC) protect AML blasts from spontaneous and chemotherapy-induced apoptosis. Here, we report a novel interaction between AML blasts and BM-MSCs, which benefits AML proliferation and survival. We initially examined the cytokine profile in cultured human AML compared with AML cultured with BM-MSCs and found that macrophage migration inhibitory factor (MIF) was highly expressed by primary AML, and that IL8 was increased in AML/BM-MSC cocultures. Recombinant MIF increased IL8 expression in BM-MSCs via its receptor CD74. Moreover, the MIF inhibitor ISO-1 inhibited AML-induced IL8 expression by BM-MSCs as well as BM-MSC-induced AML survival. Protein kinase C β (PKCβ) regulated MIF-induced IL8 in BM-MSCs. Finally, targeted IL8 shRNA inhibited BM-MSC-induced AML survival. These results describe a novel, bidirectional, prosurvival mechanism between AML blasts and BM-MSCs. Furthermore, they provide biologic rationale for therapeutic strategies in AML targeting the microenvironment, specifically MIF and IL8. Cancer Res; 77(2); 303-11. ©2016 AACR.
Daunorubicin Loaded Magnetic Nanoparticles of Fe3O4 Greatly Enhance the Responses to Chemotherapy and Induce Apoptosis of Multidrug-Resistant K562 Cells in a Human-Nude Mice Xenograft Leukemia Model
Authors: Bao-An Chen, Bin-bin Lai, Jian Cheng, Feng Gao, Wen-lin Xu, Hui-lin Shen, Jia-hua Ding, Chong Gao, Yun-yu Sun, Jun Wang, Gang Zhao, Hui-hui Song, Wen Bao, Xinchen Sun, Hong-yan Cheng, Yu-xia Deng, Guo-hong Li, Li-jie Liu, Wen-ji Chen, Ze-ye Shao, Guo-hua Xia, Jue-qiong Wang, Peng Yuan, Xiao-ping Pei, Ning-na Chen, Qin-ning Li, Xue-mei Wang
Journal: Blood (2008)
Clinical and Biological Features, Treatment and Long-Term Outcome of 65 Children with Ph- Myeloprolipherative Disorders (MPD).
Authors: Fiorina Giona, Luciana Teofili, Giovanna Palumbo, Maria Luisa Moleti, Massimiliano Rea, Sonia Maria Orlando, Vittorio Nunes, Anna Maria Testi, Valerio Cecinati, Sara Capodimonte, Mauro Nanni, Luigi Maria Larocca, Robin Foà
Journal: Blood (2009)
PWE-132 Is The NHS Ready for Video-Conference Consultations in Outpatient Clinics?
Authors: E Antoni, MF Jaboli, M Samarasinghe, A Mohamed, O Epstein
Journal: Gut (2016)

<h3>Introduction</h3> Past literature has explored qualitative differences between teleconsultation and conventional face-to-face consultation in the context of diabetes care. However, designing the algorithm of such innovative consultations necessitates inclusion of patients’ ideas and concerns so as to optimise their practicality and be adequately tailored to patients’ needs. Hence, the Centre of Gastroenterology at the Royal Free Hospital in London decided to involve patients through a questionnaire focusing on the design of synchronous teleconsultation through video-conferencing. <h3>Methods</h3> We aimed to identify: 1)Patients’ responses to introducing video-conferencing and explore factors contributing to their decision and 2)Patient groups in which video-conferencing would be more applicable. We analysed responses of 137 patients attending the gastroenterology outpatient clinic between April-August 2015. ‘Positive response’ (PR) was defined as patients who would consider a video-conference consultation compared to a conventional face-to-face method/’negative response’ (NR). Further analysis identified potential factors contributing to a PR such as age and employment status as well as device, software and consultation type preferences. We were also interested as to whether video-conferencing would improve patient attendance. <h3>Results</h3> PRs (n = 68): Also refer to figure 1. &gt;50% were &lt;60 years old compared to only 30% aged ≥60 years. The majority had current/previous work experience (full-time 62%,part-time 62% and retired 68%). Patients indicated preference towards bigger screens:computer(56%), portable device(47%) and smartphone(36%). 70% preferred Skype and 30% facetime while 1/3 preferred having a video-conference as their 1st appointment and 2/3 as their follow-up. 41% indicated they would be more likely to attend a video-conference compared to 59% who indicated their attendance would either decrease or remain unaffected. <h3>Reasons for NRs (n = 69)</h3> Lack of confidence with device (57%), Lack of privacy at home/work(12%) and Other reasons (38%). <h3>Conclusion</h3> Results suggested that a traditional face-to-face interaction is more suitable for a first consultation, however video-conferencing could be a beneficial alternative for follow-up.Video-conferencing would be more applicable to patients aged &lt;60, with work experience and potentially greater exposure to technology. Preference for a bigger screen may indicate a need for a more realistic and personal interaction with the doctor, while widespread accessibility of Skype provides the most convenient option. We feel that acquisition of more experience in utilising technology in the near future can increase the acceptability of video-conferencing with similar quality of care to conventional methods of consultation. <h3>Disclosure of Interest</h3> None Declared
Serum Immunoglobulin Free Light Chain (sFLC) Measurement as a New Marker of Response to Therapy and Survival in Waldenstrom Macroglobulinemia (WM).
Authors: Xavier Leleu, Renee Leduc, Meghan Rourke, Stacey Chuma, Amy Sam, Brianna Harris, Janet Kunsman, Irene M. Ghobrial
Journal: Blood (2009)
AB0474 A Prospective Evaluation of Endothelial Dysfunction in Systemic Lupus Erythematosus Patients without Previous Cardiovascular Events: Preliminary Results
Authors: M. Taraborelli, E. Sciatti, I. Bonadei, V. Terlizzi, M. Fredi, R. Zani, G. Cancarini, A. Tincani, F. Franceschini, E. Vizzardi, I. Cavazzana
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Cardiovascular disease (CVD) due to premature atherosclerosis is a leading cause of morbidity and mortality in Systemic Lupus Erythematosus (SLE) patients. Early identification of patients with subclinical disease and tight control of cardiovascular risk factors are essential to reduce such complication [1,2]. <h3>Objectives</h3> To assess the prevalence of endothelial dysfunction (ED) by a non invasive procedure in SLE patients with early disease without history of CVD. <h3>Methods</h3> SLE patients, according to 2012 Classification Criteria, with a disease duration less than 5 years, followed in the Rheumatology and Nephrology Unit of our Hospital were proposed to perform a cardiologic evaluation. Exclusion criteria were represented by: history of CVD, diabetes, chronic renal disease (creatinine clearance&lt;60 ml/min), not controlled systemic arterial hypertension, current smoking or smoking in the last 3 years, hypercholesterolemia (total cholesterol&gt;240 mg/dl), obesity (body mass index ≥30), statin or beta-blocker use. Each patient underwent a clinical and serological evaluation, a transthoracic doppler echocardiogram and an evaluation of endothelial function by endoPAT technique. Patients with ED, defined as reactive hyperemic index ≤2, were compared to those without ED by Fisher, T student or Mann-Whitney tests as appropriate. <h3>Results</h3> We enrolled 17 SLE patients (100% female, 88% caucasian) with a median disease duration of 14 months (0–68), a mean age of 41 years (±16), and a mean age at diagnosis of 39 years (±17). Five patients (29%) had a systemic hypertension that was well controlled by treatment. No other cardiovascular risk factors were present. Disease characteristics and treatment are shown in Table I. Echocardiogram showed diastolic dysfunction in 3 patients. EndoPAT identified 7 patients (41%) with ED. We did not find any significant association between the presence of ED and demographic-clinical-serological characteristics of patients or treatments or echocardiografic findings. A tendency for an association with an history of renal disease was observed (57% versus 0%, p:0.058). <h3>Conclusions</h3> A significant proportion of SLE patients showed signs of ED despite a recent disease and the absence of significant cardiovascular risk factors. <h3>References</h3> Ramos-Casals M. The ill endothelium: how atherosclerosis begins in lupus. Rheumatology (Oxford) 2014; 53:583–5. Yildiz A, Soydinc S. Diastolic dysfunction and endothelial dysfunction in systemic lupus erythematosus. Rheumatol Int 2015;35:1281–2. <h3>Disclosure of Interest</h3> None declared
PTH-009 New Generation High Definition Colonoscopes Increase Adenoma Detection within The Bowel Cancer Screening Programme
Authors: A Bond, G Fisher, S Subramanian, P O’Toole, N Haslam, C Probert, T Cox, S Sarkar
Journal: Gut (2016)

<h3>Introduction</h3> Adenoma detection rate (ADR) is the most important quality indicator for screening colonoscopy, due to its association with colorectal cancer outcomes. As a result a number of techniques and technologies have been proposed that have the potential to improved ADR. The aim of this study was to assess the potential impact of the new generation high definition colonoscopies (Olympus LUCERA ELITE H290) on ADR within the Bowel Cancer Screening Programme (BCSP) in one UK centre. <h3>Methods</h3> This was a retrospective observational study in patients undergoing an index screening colonoscopy within the Liverpool &amp; Wirral BCSP. The examination was performed with either the standard definition (SD) colonoscopes (Olympus 240/260 series) or the high definition (HD) colonoscope (Olympus H290 system) with the primary outcome measure of ADR and mean adenoma per procedure (MAP) between the 2 groups. Logistic regression modelling was used to assess the impact of variable on ADR. <h3>Results</h3> 395 patients (60.5% male, mean age 66.8 years) underwent screening colonoscopy with 45% performed with HD colonoscopies. A caecal intubation rate of 97.5% was recorded. The mean mean adenoma per procedure (MAP) in the HD groups was 2.1 (+/-±2.0), whilst in the SD group it was 1.6 (+/-±1.8) (p = 0.01). The overall ADR for the 394 patients was found to be 68.6%. ADR with SD was 63.13%, compared to 75.71% with HD (p = 0.007). There was no significant difference in withdrawal time. In the logistic regression only the high definition scopes (p = 0.03) and male gender (p = 0.04) was found to impact upon ADR. <h3>Conclusion</h3> Whilst it’s established males have greater adenoma burden then females, our study has highlighted the impact of the new generation High Definition colonoscope (H290 Series) on improving adenoma detections rates, thus potentially improving long-term outcomes within the BCSP. <h3>Disclosure of Interest</h3> None Declared
THU0518 New Cardiovascular Risk Factors Screening in Patients with Gout
Authors: J.C. Ordόñez, M. Andres, J.A. Bernal, F. Sivera, L. Carmona, P. Vela, E. Pascual
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Gout is a disease triggered by the crystallization of uric acid in the joints secondary to persistent hyperuricemia, that leads to chronic inflammation. Patients with gout frequently have comorbidities including cardiovascular (CV) disease, kidney failure, diabetes mellitus etc. In fact, some these can increase the levels of uric acid and contribute to develop gout, and also deteriorate the CV profile of these patients. Therefore, their control and identification is essential for a proper management. <h3>Objectives</h3> To assess the prevalence of unknown cardiovascular risk factors (CVRF) in patients with gout. <h3>Methods</h3> Cross-sectional analysis of a inception cohort of gout patients recruited by consecutive sampling in our rheumatology unit. Gout was diagnosed by visualization of monosodium urate crystals in synovial fluid or tophus sample. A structured CV assessment included CVRF, measurement of blood pressure, anthropometry and lab tests. Arterial Hypertension (AH) was defined by previous diagnosis, blood pressure ≥140/90mmHg and/or use of antihypertensive agents. Type 2 Diabetes Mellitus (DM-2) was defined by previous diagnosis, fasting blood glucose ≥126 mg/dL, glycosylated hemoglobin ≥6.5%; presence of microangiopathic complications was also registered. Dyslipidemia (DLP) was defined by previous diagnosis, use of hypolipidemic agents, or total cholesterol&gt;200 mg/dL and/or triglycerides &gt;150 mg/dL. A descriptive analysis of the results is presented. <h3>Results</h3> The study involved 199 patients. The mean age was 63.4 (SD ±13.2) years, with 171 (85.9%) men. At inclusion the prevalence of CVRF was: AH in 136 patients (68.3%), DLP in 13 (51.8%), and DM-2 in 47 (23.6%). Seventy-six (38.6%) were found obese, smoking background was present in 40 (20.1%), use of diuretics (loop and/or thiazide) in 87 (43.7%), and chronic renal failure in 57 (28.6%). After structured assessment, the following undiagnosed CVRF were found: DLP in 59 patients (29.6%), AH in 20 (10.1%) and DM-2 in 14 (7%). New CVRF were found in 94 (46.7%) patients, among them 52 (26.1%) had one CVRF, 13 (6.5%) had 2 CVRF, and even 3 CVRF were identified in 2 cases (1.0%). The final prevalence of CVRF in included gout patients is shown in the Figure. <h3>Conclusions</h3> Half of our patients showed at least one unknown CVRF, mostly DLP followed by hypertension and DM-2. This finding highlights the need for active screening for new CVRF in patients diagnosed with gout, due to the potential impact on the proper CV management. <h3>Disclosure of Interest</h3> None declared
Vorinostat in Combination with Lenalidomide (L) and Dexamethasone (d) in Multiple Myeloma Patients Refractory to Previous Lenalidomide-Containing Regimens: Results of a Phase IIb Trial
Authors: Larysa Sanchez, Yucai Wang, Laura McBride, Elizabeth Bilotti, David H. Vesole, Joshua Richter, Noa Biran, Palka Anand, Kristin Ivanovski, Ann McNeill, David Siegel
Journal: Blood (2015)
High Prevalence of Relapse in Australian Children with Ph-like Acute Lymphoblastic Leukemia Despite Risk Adapted Treatment
Authors: Susan L Heatley, Teresa Sadras, Eva Nievergall, Chung Hoow Kok, Phuong Dang, Kelly Quek, Nicola C Venn, Sarah Moore, Tamara Law, Anthea Ng, Murray D Norris, Tamas Revesz, Michael P Osborn, Chris Fraser, Frank Alvaro, Glenn M Marshall, Luciano Dalla Pozza, Timothy P. Hughes, Charles G. Mullighan, Rosemary Sutton, Deborah L White
Journal: Blood (2015)
Apoptotic Pathways of Human Regulatory T Cells in Chronic Graft Versus Host Disease (cGVHD) After Allogeneic Hematopoietic Stem Cell Transplantation (HSCT)
Authors: Kazuyuki Murase, Yutaka Kawano, Jeremy Ryan, Ken-ichi Matsuoka, Gregory Bascug, Sean McDonough, Robert W Smith, Suzan Lazo-Kallanian, John Daley, John Koreth, Robert J. Soiffer, Anthony G. Letai, Jerome Ritz
Journal: Blood (2012)
Using a Redox Modality to Connect Synthetic Biology to Electronics: Hydrogel‐Based Chemo‐Electro Signal Transduction for Molecular Communication
Authors: Yi Liu, Chen‐Yu Tsao, Eunkyoung Kim, Tanya Tschirhart, Jessica L. Terrell, William E. Bentley, Gregory F. Payne
Journal: Advanced Healthcare Materials (2016)

A hydrogel-based dual film coating is electrofabricated for transducing bio-relevant chemical information into electronical output. The outer film has a synthetic biology construct that recognizes an external molecular signal and transduces this input into the expression of an enzyme that converts redox-inactive substrate into a redox-active intermediate, which is detected through an amplification mechanism of the inner redox-capacitor film.
Task specificity and the impact on both the individual and group during the formation of groups
Authors: Eric Kruger, Jacob M Vigil, Sarah S Stith
Journal: Behavioral and Brain Sciences (2016)

Abstract We agree with aspects of Baumeister et al.'s view that shared identities are necessary during initial stages of group formation. In contrast to their analysis, however, we provide evidence that the value of self-differentiation depends more on the task itself than on the stage of group development and challenge the authors to focus on the functions of the group.
Effect of Stem Cell Source From Unrelated Donors on Transplant Outcomes In Severe Aplastic Anemia (SAA): a Comparison of Unrelated Bone Marrow (BM) and Peripheral Blood Progenitor Cells (PBPC)
Authors: Mary Eapen, Jennifer LeRademacher, H. Joachim Deeg, Joseph H. Antin, Richard Champlin, Jeanette Carreras, Joseph W. Fay, Jakob R. Passweg, Jakub Tolar, Judith C. W. Marsh, Mary M. Horowitz
Journal: Blood (2010)
Tumor Homing Activity of Bone Marrow-Derived Mesenchymal Stem Cell Is Highly Various Among Different Tumors On Syngeneic Mouse Model Using Real-Time in Vivo Imaging Technique.
Authors: Su-Peng Yeh, Wen-Jyi Lo, Yu-Chien Chang, Wan-Ju Tsai, Chiao-Lin Lin, Yu-Min Liao
Journal: Blood (2009)
In Vitro Characteristics of Umbilical Cord Blood Derived Mononuclear Cells, CD133+ Cells and Endothelial Generating Cells and Their Effectiveness In Vivo in Mediating Neovascularization in a Murine Model of Hind-Limb Ischemia.
Authors: Marcie R. Finney, Matthew Joseph, Daniel G. Winter, Omar Masari, Margaret Kozik, Laura R. Fanning, Ying Huang, Jason Banks, Pingfu Fu, Vincent Pompili, Mary J. Laughlin
Journal: Blood (2004)
MMSET Dysregulates Gene Expression in Myeloma Through Global and Focal Changes in H3K36 and H3K27 Methylation
Authors: Relja Popovic, Eva Martinez, Quanwei Zhang, Teresa Ezponda, Yanwen Jiang, Mrinal Y. Shah, Christine Will, Eliza C. Small, Olivier Elemento, Ji-Ping Wang, Jonathan D. Licht
Journal: Blood (2012)
OC-075 Outcomes of Percutaneous Transhepatic Cholangiography for the Palliative Relief of Malignant Jaundice in England Between 2001 and 2014
Authors: JG Rees, J Mytton, F Evison, P Patel, N Trudgill
Journal: Gut (2016)

<h3>Introduction</h3> Percutaneous transcutaneous cholangiography (PTC) is widely used to relieve malignant obstructive jaundice, especially when endoscopic retrograde cholangiopancreatography (ERCP) has failed. Decompression of the biliary tree in patients who are not suitable for surgical resection may improve quality of life and facilitate palliative chemotherapy. <h3>Methods</h3> Using Hospital Episode Statistics (HES), patients with cancer of the pancreas, biliary tree, gallbladder, small intestine and liver that underwent PTC were identified. Patients who underwent curative resection post PTC were excluded. Mortality, complication rates, readmissions and variation in outcomes between healthcare providers were examined. Associations between age, sex, comorbidity, cancer type and mortality were examined using multivariate regression analysis. <h3>Results</h3> Between April 2001 and March 2014, 16,363 subjects were identified (50.2% male and mean age 73). Pancreatic cancer was the most common site at 58% and 61.1% of patients had undergone a previous ERCP. In-hospital and 30 day mortality was 15.3% (CI14.8–15.9%) and 23.1% (CI 22.5–23.8%) respectively and median survival was 92 days (IQR 33–244). There was no reduction in mortality over the study period. The percentage of patients receiving chemotherapy after their PTC was 40.7% in those aged under 60 but fell to 2.5% in those aged over 80. Emergency readmission rate was 20.6%. 35.7% of patients suffered a serious complication after their procedure, the most common being infective (16.2%), stent blockage or displacement (6.2%) and acute kidney injury (4.7%). 30 day mortality was associated with increasing age (80+ years, OR 2.91 (95% CI 2.53–3.33) p &lt; 0.001), a higher comorbidity score (20+ 3.03 (2.57–3.56) p &lt; 0.001) and pre-existing renal dysfunction (2.23 (2.00–2.40) p &lt; 0.001). Female patients had a better outlook at 30 days (0.90 (0.84–0.97) p = 0.009). 30 day mortality varied from 9.1 to 50% across providers and it was lowest in hospitals performing a higher volume of procedures per year (50+ 0.80 (0.71–0.91) p &lt; 0.001). <h3>Conclusion</h3> In subjects undergoing PTC for the palliative relief of malignant jaundice, 30 day mortality is 23.1%, major complications occur in 35.7% and readmission occurs in 20.6%. Mortality is highest in older males with increasing co-morbidity and in trusts performing low volumes of procedures. Careful multidisciplinary selection of patients who will benefit from PTC for relief of significant symptoms from jaundice or as a bridge to chemotherapy is clearly merited. <h3>Disclosure of Interest</h3> None Declared