AB0547 Cardiovascular Risk in Patients with Sjogren's Syndrome
Authors: A.B.A. Garcia, V.F.M. Trevisani, L.P. Dardin, P.A. Milani, A. Czapkowski
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The atherosclerosis is the principal cause of mortality in developed countries. Up to 75% of cardiovascular diseases can be explained by classic risk factors, like smoking, high blood pressure and sedentary lifestyle, but there is increasing evidence that chronic inflammation is an independent risk factor for accelerated atherosclerosis. Many studies show high cardiovascular risk in rheumatologic diseases and, recently, new data have revealed that patients with Sjogren9s syndrome have a significantly higher risk for heart attack and stroke than general population. <h3>Objectives</h3> The object of this study is to evaluate the cardiovascular risk in forty nine patients with Sjogren9s syndrome. <h3>Methods</h3> Traditional risk factors such as hypertension, diabetes, dyslipidaemia, smoking and family history of atherosclerosis have been assessed. Patients with prior cardiovascular events and personal history of atherosclerosis have been excluded. Clinical and laboratory features have been recorded, as well as the calculation of ESSDAI. The cardiovascular evaluation used de Framingham score, aerobic capacity (measured by ergospirometry), echocardiography, carotid intima-media thickness (CIMT), measured by ultrasonography, and ankle brachial index (ABI). <h3>Results</h3> Fifteen patients (31%) had at least one traditional risk factor and 65,3% had ESSDAI score from mild to moderate. Thirty persons (61,22%) had Framingham score between moderate to high. Only 10,2% showed a good aerobic capacity and diastolic of left ventricular dysfunction was seen on 24 patients9 echocardiography. Only two patients had increased CIMT, however, 66% presented ABI alterations. <h3>Conclusions</h3> The statistical analysis demonstrated a positive association between the Framingham and ESSDAI scores [χ<sup>2</sup>(4)=10,858; p=0,028] and this could mean that the activity of the disease is an independent cardiovascular risk factor in Sjogren9s syndrome. <h3>References</h3> Magnus P, Beaglehole R. The real contribution of the major risk factors to the coronary epidemics: time to end the "only-50%" mith. Archieves of Internal Medicine 2001;161:2657-60. Beaglehole R, Magnus P. The search for new factors for coronary heart disease: occupational therapy for epidemiologists? Internal Journal of Epidemiology 2002;31:1117-22 vab Leuven SI, Franssen R, Kastelein JJ, Levi M, Stroes ESG, Tak PP. Systemic inflammation as a risk factor for atherothrombosis. Rheumatology 2008;47:3-7. Peters MJ et al. Does rheumatoid arthritis equal diabetes mellitus as an independent risk factor for cardiovascular disease? A prospective study. Arthritis Rheum 2009;61:1571-79. Manzi S, Selzer F, Sutton-Tyrrel K, et al. Prevalence and risk factors of carotid plaque in women with Systemic lupus erythematosus. Arthritis Rheum 1999;42:51-60 Vaudo G, Bocci EB, Shoenfeld Y, Schiallaci G, Wu R, Papa ND, Vitali C, Monache FD, Marchesi S, Mannarino E, Gerli R. Precocious intima-media thickening in patients with primary Sjogren9s Syndrome. Arthritis Rheum 2005;52(12):3890-97. Avina-Zubieta A. Increased Cardiovascular Risk in Sjogren9s Syndrome. EULAR 2014 Gerli R, Bocci EB, Vaudo G, Marchesi S, Vitali C, Shoenfeld Y. Tradicional cardiovascular risk factors in primary Sjogren9s syndrome – role of dyslipidaemia. Rheumatology 2006;45:1581082 <h3>Disclosure of Interest</h3> None declared