AB0873 The evaluation of extraarticular manifestations of ankylosing spondylitis in turkish population patients
Authors: D. Evcik, S. Ataman, A. Rezvani, N. Paker, M. Birtane, T. Kaya, P. Borman, H. Bodur
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The existence of EAM in Ankylosing Spondylitis(AS) may change the treatment options and the ratio of EAM varies according to race and countries. <h3>Objectives</h3> This study was planned to evaluate the involvement ratio of EAM according to organ systems and to determine the relation between EAM and disease activity and functional level in Turkish population <h3>Methods</h3> This is a multicenter study and supported by Turkish League Against Rheumatism (TLAR) AS study group. In Turkey a web-based registry sistem project was developed by TLAR organisation and this study was based on these data. A total of 2276 AS patients were included the study. The patients with EAM were selected and its distibution over the organs including; ocular, pulmonary, cardiac, renal and neurological involvements were assessed. In order to determine the factors that affects the involvement of EAM, laboratory parameters such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), the duration of morning stiffness, Bath ankylosing spondylitis disease activity index(BASDAI) and Bath ankylosing spondylitis functional index (BASFI) were evaluated. <h3>Results</h3> In this study 158 patients with a ratio of %6.9 had EAM. Ocular involvement was most often (%76.6) and followed by pulmonary (%14.6), cardiac (%9.5), renal (%8.9) and neurological involvement (%2.5) respectively. We observed that there was statistically significant correlation between BASDAI scores and ocular (p=0.008), cardiac (p=0.010) and renal involvement (p=0.005). Also significant correlation was found between BASFI and ocular, cardiac and renal involvement (p=0.037,p=0.010 and p=0.013 respectively). However disease activity and functional level had no relation with pulmonary and neurologic involvement. Additionally no statistically significant correlation was observed between morning stiffness, ESR and CRP levels with the existence of EAM (p&gt;0.05). <h3>Conclusions</h3> The most frequent EAM was ocular involvement in Turkish AS patients. The existence of ocular,cardiac and renal involvements are closely related with disease activity and functional capacity. <h3>References</h3> Eser F, Garip Y, Bodur H.Extraarticular manifestations in Turkish patients with rheumatoid arthritis: impact of EAMs on the health-related quality of life in terms of disease activity, functional status, severity of pain, and social and emotional functioning. Rheumatol Int. 2011 Feb 16. [Epub ahead of print] Bodur H, Ataman S, Buddaycı DS, Rezvani A, Nas K, Uzunca K, Türkiye Romatizma Arattırma ve Savat Dernedi [TRASD] (Turkish League Against Rheumatism) Ankylosing Spondylitis [AS] Study Group. et al. Description of the registry of patients with ankylosing spondylitis in Turkey: TRASD-IP. Rheumatol Int. 2012;32(1):169-76. de Oliveira Sato J, Corrente JE, Saad Magalhães C. Progression of articular and extraarticular damage in oligoarticular juvenile idiopathic arthritis. Clin Exp Rheumatol. 2011;29(5):871-7 Turesson C, McClelland RL, Christianson T, Matteson E. Clustering of extraarticular manifestations in patients with rheumatoid arthritis. J Rheumatol. 2008;35(1):179-80. <h3>Disclosure of Interest</h3> None Declared