tbuckley/cabot-search huggingface dataset:
Diagnosed mental disorder in children and use of health services in four organized health care settings
Authors: A M Jacobson, I D Goldberg, B J Burns, E W Hoeper, J R Hankin, K Hewitt
Journal: American Journal of Psychiatry (1980)

The authors present comparative data on the extent, nature, and impact of diagnosed mental disorder among children under 18 years of age seen during 1975 in four organized health care settings. Between 3.3% and 10.1% of the children seen were diagnosed as having a mental disorder in the study year, representing an annual prevalence of between 2.2% and 8.2% of the "covered" child populations. Transient situational disturbances, behavior disorders, and special symptoms were the most common diagnoses; the more severe disorders (organic brain disease, schizophrenia, and affective and other psychoses) accounted for less than 4% of all diagnosed mental disorder. Patients with diagnosed mental disorder used non-mental-health services (except those of pediatricians) appreciably more often than did patients without such a diagnosis.
AB1104 Influence of Sociodemographic and Clinical Factors in Health Related Quality of Life in Patients Followed in a Rheumatology Day-Care Unit
Authors: A. Raposo, J. Sousa Neves, M. Cerqueira, F. Teixeira, D. Peixoto, J. Costa, S. Alcino, C. Afonso
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The health-related quality of life (HRQL) is an important indicator of the burden of inflammatory rheumatic diseases (IRD). Their outcomes may also be affected by coexisting chronic conditions that can cause functional impairment and activity limitation with significant reductions in HRQL. <h3>Objectives</h3> To determine the health status and quality of life in patients with IRD followed in a rheumatology day-care unit and to identify associated demographic and disease-related parameters influencing it. <h3>Methods</h3> The Health Assessment Questionnaire (HAQ) to assess impairment in daily activities due to illness and Short Form-36 (SF-36) to assess HRQL were applied to patients on day-care routine visits. Disease activity clinical measures (DAS28-ESR, ASDAS-PCR, mean pain on VAS) were collected according to the disease and the predominant involvement. A p value of &lt;0.05 was considered as significant. <h3>Results</h3> A total of 84 patients were consecutively included, predominantly female (59.5%), with a mean age of 46.25±13.25 years (range 19-85) and a mean disease duration of 14.62±8.07 years (1-38). Thirty six (42.9%) patients had rheumatoid arthritis and 48 (57.1%) had spondylarthritis. Seventy seven (91.7%) patients with current bDMARDS, 51 (60.7%) also with cDMARDS and 19 (22.6%) with low doses corticosteroid treatment. Twenty four (28.6%) had associated hypertension, 4 (4.8%) diabetes and 10 (11.9%) dyslipidemia. The mean DAS28-ERS was 2.59±1.06 (0.53 to 6.94), median ASDAS-PCR 1.40±1.15 (0.20 to 5.50), mean pain on a VAS 3.77±2.58 (0 to 10), mean HAQ 0.76±0.71 (0 to 2.88) and mean SF-36 418.71±162.31 (103.50 to 707). Strong correlation (<i>p</i>&lt;0.01) was found between high scores of HAQ and low SF-36. These scores correlated also with older age, high pain on a VAS and high disease activity measured by ASDAS-PCR and DAS28-ESR. Longer disease duration correlated as well with lower level of SF-36 (<i>p</i>&lt;0.05), but not with HAQ. Rheumatoid arthritis showed significant higher levels of HAQ than spondylarthritis. The female gender, current corticosteroid treatment and history of hypertension were associated both with higher HAQ and lower SF-36 (<i>p</i>&lt;0.05). The scores were not statistically different between bDMARDS or cDMARDS, smoking and alcohol consumption, civil or employment status, level of education or other associated diseases. <h3>Conclusions</h3> Our findings suggest that not only the activity or duration of the disease, but also the gender, concomitant comorbidities and therapies can influence the HRQL and daily activities. The disease activity could be a determinant of disability but is important to incorporate coexisting conditions and demographic data in the evaluation of HRQL. <h3>Disclosure of Interest</h3> None declared
Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11
Authors: F Baldanti, A Zanetti
Journal: Eurosurveillance (2011)

Preview this article: Letter to the editor. Virological analysis of fatal influenza cases in the United Kingdom during the early wave of influenza in winter 2010/11, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/16/4/art19774-en-1.gif
EPISODIC BLURRING OF VISION
Authors: T S BUMBALO, H V MORELEWICZ, D L BERENS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Soundings: Rocky in suburbia
Authors: Des Spence
Journal: BMJ (2006)

As students we watched Rocky IV on video rather than go to histology; somehow it just seemed more relevant. Against all international advice Rocky agrees to fight in the former Soviet Union. Once there, the Italian stallion is denied proper training facilities and resorts to chopping logs, running in the snow, and pulling carts, all to the tune of spandex rock.

His Russian opponent is seen in a hi-tech gym being pumped with steroids while attached to electroencephalograph and electrocardiograph leads. Never fear, Rocky's classic blend of guts, utter stupidity, and using his face to break his opponent's hands wins again. Two dimensional Hollywood twaddle, but enjoyable none the less.

We are in “resolution season,” with January being the busiest month for gym membership. The gym revolution has ballooned along with our waistlines over the past decade. We, the generation of the “individual,” seem desperate to cling on to that most over-rated commodity of all—youth. In the changing rooms I see tinted hair, the effects of Botox, designer thongs cleaving suet pudding buttocks, and lycra merely displacing fat into even less flattering places. I am sure it is no different in the women's locker rooms. A gyrating Madonna leers from multiple television screens as poor imitations of her sizzle on pointless treadmills.

I pretend to be Polish in gyms so as not to have to engage in tedious talk about training regimes, personal bests, charity runs, elemental diets, obscure injury syndromes, and the inevitable new fitness craze. In the cafe a 300 calorie ready meal offers only convenience in the place of comfort and company. I fear that if we are not careful it will not be the meek that inherit the earth but the terminally dull.

We all know that gyms make you feel only inadequate and unhappy. Rocky had it right. Let's walk, cycle, chop logs, and pull carts (where practical). Get dressed in the dark if it helps. Irresponsibility is the fountain of youth so age disgracefully and enjoy complaining about the young, who will in turn ignore our whining and irresponsibly squander their youth like every generation before them.

Gyms are a symptom of the modern falsehood that life can be defined by those three magic words—wealth, health, and self.
AB0763 Association Between Active MRI Inflammation of the Lumbar Spine and Low Bone Mineral Density in Patients with Early Axial Spondyloarthritis:
Authors: E. Gubar, T. Dubinina, A. Dyomina, A. Godzenko, O. Rumyantseva, S. Shubin, A. Smirnov, S. Glukhova, S. Erdes
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To study the association between MRI inflammation of the lumbar spine (LS), sacroiliac joints (SIJs) and hip joints (HJs) and bone mineral density (BMD) in LS and femoral neck (FN) in early axial spondyloarthritis (axSpA) patients. <h3>Methods</h3> 150 patients with axSpA and &lt;5 years duration of inflammatory back pain (ASAS 2009 criteria) were examined. Median age – 27.0 (24.0 – 33.0) y., median disease duration – 21.0 (7.0 – 28.0) mo. 119 (79.3%) patients were HLA-B27 positive. Median BASDAI – 4.3 (2.2 – 6.0), ASDAS-CRP – 2.2 (1.3 – 3.3), BASFI – 1.9 (0.9 – 5.0). Median ESR – 8 (5-24) mm/h, CRP – 4.3 (1.0-20.6) mg/L. The patients fulfilled ASAS criteria. MRI of LS, SIJs and HJs (in case of hip joint pain and limitation of movement) was performed on Signa Ovation 0.35 T scanner (matrix 288x192). BMD was measured using dual energy x-ray absorptiometry (DXA) of the femoral neck (FN) and lumbar spine (LS) (L2–4). BMD reduction was defined as Z score ≤-2 (at at least one site) <h3>Results</h3> MRI inflammation of LS and/or SIJ, and/or HJs has been found in 117 (78.2%) patients. Among the 117 patients of this group 21 (17.9%) had BMD reduction in LS and/or FN. And in the group of patients without MRI inflammation (n=33; 22.0%) low BMD was found in 6 (4.0%) patients (<i>p</i>=0.96). MRI-sacroiliitis was documented in 102 (68.6%) patients. Among them BMD reduction was found in 17.8%. While in the group of patients without MRI inflammation of SIJs low BMD has been found in 22.5% (<i>p</i>=0.73). MRI-coxitis was observed in 24 (22.5%) patients, and was associated with low BMD in 12.5% of cases. In the group of patients without inflammatory lesion in HJs, BMD reduction was found in 22.9% patients (<i>p</i>=0.27). Lumbar spine MRI-spondylitis was observed in 27 (19%) patients, and was associated with low BMD in 33.3% of cases. Meanwhile among the group of patients without MRI-spondylitis of the LS, BMD reduction was documented in 15.2% of cases (<i>p</i>=0.03). MRI findings and DEXA data are shown in the Table. <h3>Conclusions</h3> Correlation has been detected between active MRI-spondylitis of the LS and BMD reduction in LS and/or FN. This demonstrates that in patients with early axSpA low BMD is a result of inflammation. <h3>Disclosure of Interest</h3> None declared
Going Up?
Authors: Carolyn Daher
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
S-Phase Population Analysis Does Not Correlate with the Cytotoxicity of Camptothecin and 10,11-Methylenedioxycamptothecin in Human Colon Carcinoma HT-29 Cells
Authors: P M O'Connor, W Nieves-Neira, D Kerrigan, R Bertrand, J Goldman, K W Kohn, Y Pommier
Journal: Cancer Communications (1991)

Previous studies in rapidly proliferating rodent cells have suggested that the lethal effect of the DNA topoisomerase I inhibitor, camptothecin (CPT) is dependent upon the active participation of DNA replication (Holm et al. Cancer Res. 49:6365-6368; 1989). The purpose of the current study was to determine if this relationship applies to more slowly growing human cells. In our present study, we employed the human colon carcinoma cell line, HT-29 (45 hr doubling time). Flow cytometric determination of S-phase cells either by S-phase fit model or rectangle fit model analysis predicted that 21% of exponentially growing HT-29 cells were undergoing DNA replication. These findings were confirmed by immunofluorescence microscopy of bromodeoxyuridine labeled cells. Based on these findings, we would have expected only 20-30% of the cells to be susceptible to brief treatment (30 min) with CPT. Instead, 90-95% of HT-29 cells were killed. This apparent disparity was not due to prolonged cellular retention of drug after treatment because protein-linked DNA strand breaks reversed within 15 min of drug removal. Moreover, the DNA replication inhibitor, aphidicolin, fully protected HT-29 cells against CPT-induced killing but did not affect the production of CPT-induced protein-linked DNA strand breaks. Similar results were also obtained using the CPT-analog, 10,11-methylenedioxy-camptothecin, which was 5- to 10-fold more potent than camptothecin (O'Connor et al. Cancer Commun. 2:395-400; 1990).(ABSTRACT TRUNCATED AT 250 WORDS)
Time to unrelated donor leukocyte infusion is longer, but incidence of GVHD and overall survival are similar for recipients of unrelated DLI compared to matched sibling DLI
Authors: Anita J. Kumar, Pavel Vassilev, Alison W. Loren, Selina M. Luger, Ran Reshef, Saar Gill, Jacqueline Smith, Steven C. Goldstein, Elizabeth Hexner, Edward A. Stadtmauer, David Porter, Noelle V. Frey
Journal: American Journal of Hematology (2016)

Donor leukocyte infusion (DLI) is used to treat relapsed leukemia after allogeneic hematopoietic stem cell transplant (HCT). Data comparing outcomes after unrelated DLI (uDLI) to matched sibling DLI (msDLI) are scant. We performed a retrospective analysis to assess differences in time to administer uDLI versus msDLI, and impact on outcomes. Fifty three patients with relapsed acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), or myelodysplastic syndrome (MDS) after allogeneic HCT received uDLI (n = 18) or msDLI (n = 35) from 2000 to 2011. Median time from relapse to uDLI request was 15 days (range 0-66). Median time from relapse to uDLI was 56 days versus 40 days for msDLI patients (p = 0.034). 35% of msDLI and 44% of uDLI patients developed acute GVHD (p = 0.50). There was no significant difference in Grade C/D GVHD among uDLI and msDLI (28% and 21%, p = 0.58) or median OS after DLI between uDLI and msDLI (95 versus 75 days, p = 0.76). For patients with relapsed acute leukemia and MDS after allogeneic HCT, time from relapse to uDLI was longer than to msDLI, but incidence of GVHD and overall survival were similar. Access to uDLI does not appear to be a barrier to DLI administration. Outcomes unfortunately remain poor regardless of donor source.
GLYCYRRHIZIN-INDUCED INHIBITION OF THE PITUITARY-ADRENAL STRESS RESPONSE
Authors: Shirley D. Kraus
Journal: The Journal of Experimental Medicine (1958)

Glycyrrhizin decreased the resistance of intact male mice to prolonged exposure to cold (8 hours at 5°C.) and it decreased the ability of intact male rats to mobilize glucose when subjected to 48 hours of fasting. It is suggested that glycyrrhizin, like desoxycorticosterone, depresses the output of ACTH.
PTU-111 A review of chronic hepatitis b virus infection in children in ireland
Authors: R Finnegan, K Tuite, R Liddy, M Goode, A Rochford, S McDonagh, K Butler, P Gavin
Journal: Gut (2015)

<h3>Introduction</h3> Although the majority of children with hepatitis B virus (HBV) infection remain asymptomatic, serious complications such as cirrhosis and hepatocellular carcinoma can occur in later life. Longterm follow up is important to identify these complications early. In Ireland, pregnant women are screened antenatally for HBV. Children born to HBV infected mothers are referred to the Rainbow Clinic. <h3>Method</h3> Data on all children with chronic HBV infection, attending the Rainbow Clinic from 2002 to 2014, were retrospectively reviewed using a standard data collection sheet. Chronic HBV infection is defined as HBsAg-positivity for greater than 6 months. Children with only one clinic visit or with HIV co-infection were excluded. <h3>Results</h3> 63 children with chronic HBV infection attended the Rainbow clinic between 2002 and 2014 (age range, 6 months-17 years).6 children were excluded (4 single clinic attendance; 2 HIV co-infection). 34 children (60%) were male. 13 children (23%) with chronic HBV were born in Ireland. The majority (44, 77%) were children immigrating to Ireland from overseas: Africa, 16; Central Asia, 14; Eastern Europe, 7; Unknown, 7. HBV was acquired vertically in 35 (61%) children and horizontally in 2. Parental HBV status was unknown in 22 children (15 adoptees).19 children had siblings with chronic HBV infection. 9 of 13 (69%) children born in Ireland received recommended prophylactic IVIG and HBV vaccine at birth. 4 (31%) received no prophylaxis. Birth details from children born outside of Ireland show suboptimal post natal prophylaxis in all: 13 of 16 received no prophylaxis and 3 received HBV vaccine alone. All 57 children had biochemistry performed twice a year. Abdominal ultrasound scans (USS) were performed in 49 children (86%).5 had abnormal USS (coarse echogenicity, 3; splenomegaly, 2). Liver biopsy was performed in 4 children with elevated ALT and high HBV VL. Biopsies showed fibrosis (3) or minimal inflammation (1). USS was normal in 3 of the 4 cases with abnormal biopsy. 3 children received antivirals (3TC) for fibrosis (2) and to reduce risk of transmission (1). <h3>Conclusion</h3> Immigration to Ireland accounts for the majority of paediatric HBV infection in this country. The majority of chronic HBV infection in children results from vertical transmission. Failure of postnatal prophylaxis remains a significant problem. Available evidence shows that 100% of foreign-born and 30% of Irish-born children with chronic HBV did not received recommended IVIG and vaccine prophylaxis. 4 children (7%) developed complications of chronic HBV. The need for improved diagnostic tools to identify children at risk of complicated HBV liver disease is again evidenced by failure of USS to identify those children with biopsy-proven abnormalities. <h3>Disclosure of interest</h3> None Declared.
Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-Cell Acute Lymphoblastic Leukemia
Authors: Yana Pikman, Andrew Furman, Emily S. Lee, Andrew E. Place, Gabriela Alexe, Rebecca Modiste, Prafulla Gokhale, Sunkyu Kim, Lewis B. Silverman, Kimberly Stegmaier
Journal: Blood (2015)
Website of the week: Teach yourself statistics
Authors: Christopher Martyn
Journal: BMJ (2001)

A glance at this week's (or any week's) BMJ will show that medical research inevitably involves statistics. In his self help book of the 1930s, Mathematics for the Million, Lancelot Hogben included a chapter on statistics entitled “The Arithmetic of Human Welfare”—a warm, almost touchy-feely description of a subject that many doctors still regard as repellently algebraic. Unfortunately the chapter doesn't live up to its title. The explanations are long winded and often tough going. Technology, however, has made things easier for Hogben's successors. The possibilities created by Java applets for interactive tutorials make the web a good place for the statistical novice to look.

The Rice Virtual Lab in Statistics (www.ruf.rice.edu/∼lane/rvls.html) provides HyperStat, an online statistics book. Its strong point is not the text but the excellent simulations that accompany it. There are clear demonstrations of many of the things that most of us struggle to grasp—the central limit theorem, regression to the mean, the binomial distribution, etc. Especially good is the display of how transformations by, for example, square roots or logarithms can affect the interpretation of a relationship between two variables. The site also has case studies to take you through statistical analyses of real data and an analysis lab, where you decide how to explore example data sets.

At http://members.aol.com/johnp71/javastat.html, John C Pezzullo, a professor of pharmacology and biostatistics, has compiled a list of more than 600 links to web based statistical resources. They are grouped into sensible categories, and it's not hard to find interesting and useful stuff. Several sites allow you to enter your own data and analyse it. Others provide such things as glossaries of statistical terms (www.cas.lancs.ac.uk/glossary_v1.1/main.html and www.statsoft.com/textbook/glosfra.html), random number generators (http://home.clara.net/sisa/random.htm), power and sample size calculations (http://ebook.stat.ucla.edu/calculators/powercalc/), and printable statistical tables in pdf format (http://fsweb.berry.edu/academic/education/vbissonnette/tables.html).
Pleural Effusion
Authors: Carolyn J. Hildreth
Journal: JAMA (2009)

Pleural EffusionW hen an abnormal amount of fluid accumulates in the space between the 2 layers of the pleura (the membrane that lines the surface of the lungs), it is called a pleural effusion.It is estimated that 1 million people in the United States develop a pleural effusion each year.About 20% to 60% of the people who develop pneumonia have a pleural effusion.A pleural effusion can also occur due to an extrapulmonary (outside the lungs) cause.Treatment depends on the underlying cause.The January 21, 2009, issue of JAMA includes an article about diagnosing pleural effusions.
Ubiquitous VEA
Authors: William B. Hood
Journal: New England Journal of Medicine (1975)

Not much more than a decade ago ventricular ectopic activity (VEA) was widely ignored in ambulatory patients with ischemic heart disease, and even in patients hospitalized for acute myocardial infarction, VEA was often untreated. This oversight has been rectified by the advent of coronary-care units, with salubrious results. Now we find ourselves in the position of wishing to extend our coronary-care-unit experience to the community of ambulatory patients with coronary-artery disease, to avert the overwhelming problem of sudden death from ventricular arrhythmias, and not quite knowing how to proceed. In our hospitalized patients, about to be discharged, and in our . . .