tbuckley/cabot-search huggingface dataset:
Virus of Avian Erythromyeloblastic Leukosis. III. Interrelations of Plasma Particles, Infectivity, and the Enzyme Dephosphorylating Adenosine Triphosphate&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Edward A. Eckert, D. G. Sharp, E. B. Mommaerts, Robert H. Reeve, Dorothy Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article Virus of Avian Erythromyeloblastic Leukosis. III. Interrelations of Plasma Particles, Infectivity, and the Enzyme Dephosphorylating Adenosine Triphosphate Get access Edward A. Eckert, Edward A. Eckert Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar D. G. Sharp, D. G. Sharp Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar E. B. Mommaerts, E. B. Mommaerts Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert H. Reeve, Robert H. Reeve Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar Dorothy Beard, Dorothy Beard Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. W. Beard J. W. Beard Department of Surgery, Duke University School of Medicine, Durham, N. C. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 5, April 1954, Pages 1039–1053, https://doi.org/10.1093/jnci/14.5.1039 Published: 01 April 1954 Article history Received: 27 November 1953 Published: 01 April 1954
A Chilly Fever
Authors: Christin Price, Cameron Ashbaugh, Amy Leigh Miller, Joseph Loscalzo
Journal: New England Journal of Medicine (2014)

A 30-year-old graduate student presented with fevers associated with shaking chills and severe headaches. He had been well until 1 week before presentation, when he began to have daily fevers, with temperatures as high as 39.4°C.
Abstract A49: Investigating the expression of inhibitory surface molecules in ovarian cancer tumor-infiltrating lymphocytes.
Authors: Jessica Chacon, Tori Yamamoto, Thomas Garrabrant, Gabor Kari, Andrew Best, Qunrui Ye, Daniel Powell
Journal: Clinical Cancer Research (2016)

Abstract Ovarian cancer causes more deaths than any other cancer of the female reproductive system. However, novel therapies, including immunotherapy are now being utilized to treat this cancer. In addition, efforts have been made to identify and evaluate the subsets of cells within the tumor environment that correspond with patient overall survival. Although the presence of intraepithelial CD3+ T cells and CD8+ T cells have been correlated with patient survival and CD137, a co-stimulatory molecule, has been identified as a biomarker for tumor-reactive cells, studies have not thoroughly investigated the phenotype of the T cells, specifically the CD4+, CD8+, and CD137+ subsets. In our study, we used a multi-parameter flow cytometry to measure inhibitory molecules, Th1 cytokines, and the effector phenotype in the T-cell subsets. We observed that the CD4+ and CD8+ T cells found within the tumor environment express inhibitory receptors, very limited Th1 cytokine producing cells and a decreased expression of Granzyme B within the CD8+ subset. The CD137+ population also expressed inhibitory molecules, but was still able to exhibit an effector phenotype and comprise Th1 cytokine producing cells. In conclusion, using multi-parameter flow cytometry enabled us to investigate the expression of inhibitory molecules on the CD4+, CD8+, and CD137+ subsets and measure their effector phenotype. We found that the T cells express many inhibitory receptors and this may hinder their ability to become optimal effector cells that maintain tumor control. However, future studies utilizing antibodies that block these inhibitory receptors may increase the T cells' ability to exhibit an increased effector phenotype and contain more Th1 cytokine producing cells. Citation Format: Jessica Chacon, Tori Yamamoto, Thomas Garrabrant, Gabor Kari, Andrew Best, Qunrui Ye, Daniel Powell, Jr. Investigating the expression of inhibitory surface molecules in ovarian cancer tumor-infiltrating lymphocytes. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A49.
NHS spends £820m a year keeping older patients in hospital unnecessarily
Authors: Adrian O’Dowd
Journal: BMJ (2016)

The NHS in England wastes nearly £1bn (€1.31bn; $1.47bn) every year treating older patients in hospital who no longer need acute care, the National Audit Office (NAO) has said.

On 26 May the public spending watchdog published Discharging Older Patients from Hospital ,1 in which it said that health and social care services’ management of discharging older patients from hospital did not represent value for money.

The NAO estimated that the gross annual cost to the NHS of treating older patients in hospital who no …
Activation of concurrent apoptosis and necroptosis by SMAC mimetics for the treatment of refractory and relapsed ALL
Authors: Scott McComb, Júlia Aguadé-Gorgorió, Lena Harder, Blerim Marovca, Gunnar Cario, Cornelia Eckert, Martin Schrappe, Martin Stanulla, Arend von Stackelberg, Jean-Pierre Bourquin, Beat C. Bornhauser
Journal: Science Translational Medicine (2016)

SMAC mimetics simultaneously activate two different cell death pathways in treatment-resistant ALL.
Liver Necrosis after Halothane Anesthesia—Post Hoc, Ergo Propter Hoc?
Authors: V M VICTOROFF
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Characteristics of schizophrenic and depressed patients excluded from clinical research
Authors: R D Miller, R Strickland, J Davidson, R Parrott
Journal: American Journal of Psychiatry (1983)

The process of selecting patients for research studies introduces factors that can bias outcome. The authors compared schizophrenic and depressed patients accepted for studies on their clinical research unit with patients admitted to the hospital with the same diagnoses. They found significant differences between the two groups in age, sex, and legal status. The authors conclude that many research populations may not be representative of general patient populations for a number of reasons and argue that research studies also need to focus on patients who do not meet research ward criteria.
Inducing labour in women with suspected large babies shows benefits
Authors: Jacqui Wise
Journal: BMJ (2016)

Inducing labour in women with suspected large babies reduces birth fractures and mean birth weight and does not increase the rate of caesarean section or instrumental birth, a Cochrane review has found.1

Large babies, those over 4 kg (9 lb), are at increased risk of shoulder dystocia and trauma, particularly fractures and brachial plexus injury. Women with suspected fetal macrosomia are at greater risk of caesarean section or instrumental birth.

Inducing labour early may reduce birth injuries, but, if done too early, …
Pathology in Fields Collateral to Tissue Culture&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Harry S. N. Greene
Journal: JNCI Journal of the National Cancer Institute (1957)

Pathology in Fields Collateral to Tissue Culture Get access Harry S. N. Greene Harry S. N. Greene Department of Pathology, Yale University School of Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 4, October 1957, Pages 711–733, https://doi.org/10.1093/jnci/19.4.711 Published: 01 October 1957 Article history Received: 28 May 1957 Published: 01 October 1957
Preliminary investigation of bulimia and life adjustment
Authors: C Johnson, D J Berndt
Journal: American Journal of Psychiatry (1983)

Despite the reported increase in the incidence of bulimia, little is known about the life adjustment of bulimic patients. The authors surveyed 80 women who met the DSM-III criteria for bulimia regarding their adjustment in the areas of work, social and leisure activities, relationship with extended family, role as spouse, role as parent, and membership in the family unit. The life adjustment of the bulimic sample was significantly poorer in all areas than that of a normal community sample and was most similar to that of a comparison group of alcoholic women.
Galectin-1 suppression delineates a new strategy to inhibit myeloma-induced angiogenesis and tumoral growth in vivo
Authors: P Storti, V Marchica, I Airoldi, G Donofrio, E Fiorini, V Ferri, D Guasco, K Todoerti, R Silbermann, J L Anderson, W Zhao, L Agnelli, M Bolzoni, E Martella, C Mancini, N Campanini, D M Noonan, P G Petronini, A Neri, F Aversa, G D Roodman, N Giuliani
Journal: Leukemia (2016)
Formation of Tyrosine Crystals from Leukocytes and Various Normal and Pathological Tissues by Means of a Synthetic Detergent&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: William W. Ayres, MC USN
Journal: JNCI Journal of the National Cancer Institute (1950)

Formation of Tyrosine Crystals from Leukocytes and Various Normal and Pathological Tissues by Means of a Synthetic Detergent Get access William W. Ayres, MC USN William W. Ayres, MC USN Commander Laboratories of Pathology, Naval Medical School, National Naval Medical Center, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 6, June 1950, Pages 1239–1257, https://doi.org/10.1093/jnci/10.6.1239 Published: 01 June 1950 Article history Received: 14 February 1950 Published: 01 June 1950
Tumor Lipoids: Part I. Preparation of a Serologically Active Nonsaponifiable Fraction of Liver of Cancer-bearing Patients<xref ref-type="fn" rid="fn1"><sup>2</sup></xref>
Authors: Harry S. Penn, M. D.
Journal: JNCI Journal of the National Cancer Institute (1952)

Tumor Lipoids: Part I. Preparation of a Serologically Active Nonsaponifiable Fraction of Liver of Cancer-bearing Patients Harry S. Penn, M. D. Harry S. Penn, M. D. Research Associate, Department of Zoology, University of California at Los Angeles, Los Angeles, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1389–1399, https://doi.org/10.1093/jnci/12.6.1389 Published: 01 June 1952 Article history Received: 14 March 1951 Published: 01 June 1952
Prognostic factors for breast cancer: have they met their promise?
Authors: C K Osborne
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.5.679 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1569440 Prognostic factors for breast cancer: have they met their promise? C K OsbornexC K OsborneSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.5.679 First Page PDF © 1992 by American Society of Clinical Oncology
In Situ Transfection by Controlled Release of Lipoplexes Using Acoustic Droplet Vaporization
Authors: Benjamin A. Juliar, Melissa M. Bromley, Alexander Moncion, Denise C. Jones, Eric G. O'Neill, Christopher G. Wilson, Renny T. Franceschi, Mario L. Fabiilli
Journal: Advanced Healthcare Materials (2016)

Localized delivery of nucleic acids to target sites (e.g., diseased tissue) is critical for safe and efficacious gene therapy. An ultrasound‐based technique termed acoustic droplet vaporization (ADV) has been used to spatiotemporally control the release of therapeutic small molecules and proteins contained within sonosensitive emulsions. Here, ADV is used to control the release of lipoplex—containing plasmid DNA encoding an enhanced green fluorescent protein reporter—from a sonosensitive emulsion. Focused ultrasound (3.5 MHz, mechanical index (MI) ≥ 1.5) generates robust release of fluorescein (i.e., surrogate payload) and lipoplex from the emulsion. In situ release of the lipoplex from the emulsion using ADV (MI = 1.5, 30 cycles) yields a 55% release efficiency, resulting in 43% transfection efficiency and 95% viability with C3H/10T1/2 cells. Without exposure to ultrasound, the release and transfection efficiencies are 5% and 7%, respectively, with 99% viability. Lipoplex released by ADV retains its bioactivity while the ADV process does not yield any measureable sonoporative enhancement of transfection. Co‐encapsulation of Ficoll PM 400 within the lipoplex‐loaded emulsion, and its subsequent release using ADV, yield higher transfection efficiency than the lipoplex alone. The results demonstrate that ADV can have utility in the spatiotemporal control of gene delivery.
Red Cell Regulation of Tumor Necrosis Factor-Induced Human Neutrophil Cytostatic Activity
Authors: Shau Hungyi
Journal: Cancer Communications (1991)

Tumor necrosis factor (TNF) activates polymorphonuclear neutrophils (PMN) to suppress tumor cell proliferation. This cytostatic activity could be blocked by the addition of red blood cells (RBC) into the assay. TNF-induced PMN cytostatic activity was mediated by hydrogen peroxide (H2O2). RBC have two major pathways to detoxify H2O2, one by catalase and the other by the glutathione redox cycle. Therefore, the catalase inhibitor 3-amino-1,2,4-triazole (AT) and the glutathione inhibitor N-ethylmaleimide (NE) were used to assess the role of each anti-oxidant in protecting the tumor target cells. RBC, depleted of catalase by AT, no longer protected Raji tumor cells from PMN cytostatic activity. However, depletion of reduced glutathione by NE had no effect on RBC protection of tumor target cells. Thus, RBC can protect tumor cells from cytostatic activity mediated by TNF-activated PMN, and the protection is a function of catalase, but not glutathione.
Epidemiology of<i>Clostridium difficile</i>Infection–Associated Reactive Arthritis in Children
Authors: Daniel B. Horton, Brian L. Strom, Mary E. Putt, Carlos D. Rose, David D. Sherry, Julia S. Sammons
Journal: JAMA Pediatrics (2016)

The incidence of Clostridium difficile infection has increased among children. The epidemiology of pediatric C difficile infection-associated reactive arthritis is poorly understood.To characterize the incidence, recognition, and distinguishing clinical features of pediatric C difficile infection-associated reactive arthritis among children with C difficile infection.In this cohort and nested case-control study using electronic health records from January 1, 2004, to December 31, 2013, across 3 geographically diverse pediatric health care networks, we screened for reactive arthritis among 148 children between ages 2 and 21 years with diagnostic or procedural codes suggesting musculoskeletal disease associated with C difficile diagnosis or positive testing. We identified 26 cases with acute arthritis or tenosynovitis within 4 weeks before to 12 weeks after confirmed C difficile infection with (1) no alternative explanation for arthritis and (2) negative synovial cultures (if obtained). Network-matched C difficile-infected controls without arthritis were randomly selected at the time of cohort member C difficile infections.Incidence of C difficile infection-associated reactive arthritis was calculated based on (1) pediatric source population and (2) children with C difficile infection. Characteristics of cases and controls were compared using conditional logistic regression.Based on the cases identified within the source population of the 3 hospital networks, we estimated that C difficile infection-associated reactive arthritis incidence was 5.0 cases per million person-years (95% CI, 3.0-7.8). Reactive arthritis affected 1.4% of children with C difficile infection yearly (95% CI 0.8%-2.3%). Joint symptoms began a median of 10.5 days after initial gastrointestinal symptoms, often accompanied by fever (n = 15 [58%]) or rash (n = 14 [54%]). Only 35% of cases of C difficile infection-associated reactive arthritis were correctly diagnosed by treating health care professionals (range across centers, 0%-64%). Five affected children (19%) were treated for presumed culture-negative septic hip arthritis despite having prior postantibiotic diarrhea and/or other involved joints. Compared with controls, cases of C difficile infection-associated reactive arthritis were less likely to have underlying chronic conditions (odds ratio [OR], 0.3; 95% CI, 0.1-0.8). Although all cases had community-onset C difficile infection and fewer comorbidities, they were more likely to be treated in emergency departments and/or hospitalized (OR, 7.1; 95% CI, 1.6-31.7).C difficile infection-associated reactive arthritis is an underdiagnosed, potentially morbid reactive arthritis associated with C difficile infection occasionally misdiagnosed as septic arthritis. Given the rising incidence of pediatric C difficile infections, better recognition of its associated reactive arthritis is needed.
Abstract P3-01-03: Optimal concentration of indocyanine green in near-infrared fluorescence guided sentinel lymph node biopsy in breast cancer
Authors: H-J Paik, HW Yi, S Park, JM Ryu, SJ Nam, JE Lee, WH Kil, SK Lee, SY Bae, SW Kim
Journal: Cancer Research (2016)

Abstract Background: Near-infrared (NIR) fluorescence-guided sentinel lymph node biopsy (SLNB) using indocyanine green (ICG) has been successfully applied in various kinds of cancers, especially in breast cancer. Optimizing the concentration of ICG without using human serum albumin in natural lymphatic system is still required. Methods: 25mg of ICG was diluted with distilled water (DW) or normal saline (NS). Dilution concentrations used for measurement were 0.25μg/mL, 0.5μg/mL, 2.5μg/mL, 5.0μg/mL, 25μg/mL, and 250μg/mL. The brightness of fluorescence was measured by an image system called Visual Navigator (SH System, Korea). We used graphic software (GIMP, version 2.8.14, The GIMP Team) to measure the brightness. We assumed that drained serous lymphatics from a breast cancer patient can reflect a natural lymphatic condition injected with ICG in the operation field. Drained lymphatics were mixed to reduce the concentration of ICG by half that was diluted with DW or NS. We also measured the brightness of fluorescence diluted with DW or NS that was mixed with drained lymphatics. After this screening test, we subdivided the range which brightness was measured as 100 and adjusted the intensity of illumination for more specific results. Results: Highest brightness values were measured as 100 between 2.5μg/mL and 25μg/mL concentration of ICG with DW dilution in screening settings, and the values of brightness were measured as 100 between 2.5μg/mL and 5.0μg/mL concentration of ICG with NS dilution. When drained lymphatics were mixed together, the values of brightness were measured as 100 between 2.5μg/mL and 25μg/mL concentration of ICG with DW or NS dilution. After subdividing the ICG concentration to 2.5μg/mL, 3.13μg/mL, 5.0μg/mL, 6.25μg/mL, 12.5μg/mL and 25μg/mL with adjusting the intensity of illumination, the highest brightness value was measured as 76 in 5.0μg/mL concentration of ICG with DW dilution. When diluting with NS, the highest brightness value was measured as 61 in 5.0μg/mL ICG concentration. After mixing with drained lymphatics, the highest brightness value was both 79 in 5.0μg/mL concentration of ICG with DW and NS dilution. Conclusions: This study showed a practically optimal ICG concentration range in fluorescence guided SLNB. The optimal range of ICG concentration is from 3.13μg/mL to 6.25μg/mL with DW or NS dilution. Although 5.0μg/mL met the best result, adjustment for individual settings may be considered. Citation Format: Paik H-J, Yi HW, Park S, Ryu JM, Nam SJ, Lee JE, Kil WH, Lee SK, Bae SY, Kim SW. Optimal concentration of indocyanine green in near-infrared fluorescence guided sentinel lymph node biopsy in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-01-03.