tbuckley/cabot-search huggingface dataset:
Hereditary Fructose Intolerance: Clinical Study of Four Cases
Authors: J PERHEENTUPA, E PITKANEN, E A NIKKILA, O SOMERSALO, J HAKOSALO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Possible linkage between primary affective disorder susceptibility locus and HLA haplotypes
Authors: E Smeraldi, L Bellodi
Journal: American Journal of Psychiatry (1981)

The authors analyzed the concordance of sib pairs of HLA typing in cases where both sibs had affective illness and where the sibs were discordant. They detected an excess of HLA similarities in doubly affected sibs and a lack of similarities in discordant sibs. Therefore, the authors hypothesize that HLA may be linked with a primary affective disorder susceptibility locus or it may be associated with such a locus in some other way.
FRI0062 Influence of Biologic Agents on Bone Mineral Density and Bone Mineral Markers in Patients with Rheumatoid Arthritis: Data from the Airtight Study: Table 1.
Authors: M. Tada, K. Inui, Y. Sugioka, K. Mamoto, T. Okano, T. Koike, H. Nakamura
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) show problems with bone metabolism. Bone mineral density (BMD) is lower in patients with RA than in healthy individuals <sup>1</sup>. Whether biologic agents improve BMD and levels of bone mineral markers (BMM) in patients with RA remains controversial. No previous comparative studies have investigated the effects of each biologic agent on BMD and BMM. <h3>Objectives</h3> We researched the influence of biologic agents on BMD and BMM in patients with RA using a prospective, comparative design. <h3>Methods</h3> We performed this prospective, comparative study (the AIRTIGHT study; UMIN000005570) to investigate the effects of abatacept (ABT) and other biologic disease-modifying anti-rheumatic drugs (bDMARDs) on bone metabolism. A total of 165 RA patients were divided into an ABT group (n=50) and a Non-ABT group (n=115). The Non-ABT group received infliximab (n=15), etanercept (n=22), adalimumab (n=38), tocilizumab (n=26), or golimumab (n=14). We evaluated the percent change in BMD (%ΔBMD) of lumbar and femoral neck by using dual-energy X-ray absorptiometry. Urinary levels of cross-linked N-telopeptide of type I collagen (NTx) and bone-specific alkaline phosphatase (BAP) were used as markers of bone resorption and formation, respectively. <h3>Results</h3> In this study, 64% (32/50) of the ABT group and 72% (83/115) of Non-ABT group completed biologic therapy for 1 year, showing no significant difference (p=0.387). No significant differences in BMD of the lumbar and femoral neck were seen as background factors (Table 1). In %ΔBMD of the lumbar spine, no significant difference was observed (ABT: -0.40±4.31%, Non-ABT: -1.67±5.07%; p=0.524). However, the increase in femoral neck BMD was significantly higher in the ABT group (0.97±8.63%) than in the Non-ABT group (-2.19±5.49%; p=0.047). No significant differences were observed in % change of NTx (ABT: -7.01, Non-ABT: -4.43; p=0.73) or BAP (ABT: 0.44, Non-ABT: 2.21; p=0.33). The efficacy for BMM was similar for each drug. A negative correlation was seen between both BMM and changes to BMD at the femoral neck (NTx: r=-0.248, p=0.0153; BAP: r=-0.303, p=0.0023). <h3>Conclusions</h3> The increase in femoral neck BMD was significantly better in the ABT group than in the Non-ABT group. ABT may offer good efficacy for bone metabolism in patients with RA. <h3>References</h3> Haugeberg G, Uhlig T, Falch JA, et al. Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum 2000;43:522-30. <h3>Disclosure of Interest</h3> None declared
Outbreak of Escherichia coli O157 in Sweden
Authors: T Ziese, Y Anderson, B de Jong, S Löfdahl, M Ramberg
Journal: Eurosurveillance (1996)

The Swedish Institute for Infectious Disease Control (Smittskyddsinstitutet - SMI) received no more than three reports of enterohaemorrhagic E. coli O157 infections (EHEC) each year from 1988 to 1994. About half of these were due to E. coli O157. In July
HYDRATION TREATMENT OF ECLAMPSIA
Authors: H B TURNER, O DeLOZIER, F E WHITACRE
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0563 Analysis of Pleural Effusion Adenosine Deaminase (ADA) Activity in Rheumatic Disease Patients
Authors: E. Uechi, C. Nakata, T. Murayama, Y. Shiohira
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patient with rheumatic disease: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc) and vasculitis often have pleurisy. In the case of immunosuppressed pleuritic patients, it is hard to determine whether the cause of pleural effusion is the primary disease or infection, especially tuberculosis. Many studies investigated the usefulness of adenosine deaminase (ADA) in pleural fluid for the diagnosis of tuberculous pleuritis. Levels of ADA in pleural fluid &gt;50 U/L can indicate pleural tuberculosis with sensitivity 91 (%) and specificity 81 (%).It has been reported that the pleural effusions by rheumatoid arthritis tend to be high ADA activity. To our best knowledge, there is no report about the level of pleural effusion ADA with rheumatic diseases other than rheumatoid arthritis. So, we analyzed ADA activity in pleural effusion of rheumatic disease patients. <h3>Objectives</h3> To analysis for ADA value of pleural effusion associated with rheumatic diseases. <h3>Methods</h3> We extracted all the patients with diagnoses of rheumatic disease (SLE, RA, SSc, and Vasculitis) who had pleural effusion ADA examination from our electronic medical record between 2007 and 2014. We selected the case of pleural fluid associated with rheumatic diseases by exclusion of the case by other causes. We analyzed the chemistry profile (glucose, protein, lactic dehydrogenase (LDH) and ADA activity), the ratio of lymphocytes to polymorphonuclear leucocytes in pleural effusion. <h3>Results</h3> The number of rheumatic pleural fluid in 2007-2014 was 54 patients (SLE 15, RA29, SSc 3, and Vasculitis 7). Pleural effusion ADA value (U/L) (mean, median, range) was SLE (42.4, 32.9, 3.3-98.0), RA (26.2, 22.1, 4.7-65.3), SSc (15.8, 10.9, 6.6-29.9) and Vasculitis (14.9, 15.2, 2.9-29.3). The number of the case which exceed ADA cut-off value of tuberculous pleural effusion (&gt;50U/L) were 5/15 (33.3%) in SLE, 2/29 (6.9%) in RA, 0/3 in SSc and 0/7 in Vasculitis. <h3>Conclusions</h3> Pleural effusion ADA value of SLE patient was often higher than tuberculosis ADA cut-off point. Clinical course, cultivation test, and histopathological examination need to be taken into account when interpreting SLE patient9s pleural effusion ADA values. <h3>References</h3> Ocania I, Ribera E, Martinez-Vazquez J M, et al. Adenosine deaminase activity in rheumatoid pleural effusion. Ann Rheum Dis 1988; 47: 394-7. Burgess LJ, Maritz FJ, Le Roux 1 et al: Combined use of pleural adenosine deaminase with lymphocyte/neutrophil ratio. Increased specificity for the diagnosis of tuberculous pleuritis. Chest 1996; 109: 414-419. Ocania I, Martinez-Vazquez J M. Segura R M, Fernandez-De-Sevilla T, Capdevila J A. Adenosine deaminase in pleural fluids. Test for diagnosis of tuberculosis pleural effusion. Chest 1983; 84: 51-3. <h3>Disclosure of Interest</h3> None declared
Effect of Pyridoxine Deficiency on Tyrosine Transaminase Activity and Growth of Four Morris Hepatomas2
Authors: George P. Tryfiates, H. P. Morris
Journal: JNCI Journal of the National Cancer Institute (1974)

The effect of pyridoxine deficiency on the growth of 4 Morris hepatoma lines (#7777, 5123A, 7316B, and 7800) and the activity of tyrosine transaminase were investigated. Buffalo strain female weanling rats were fed for 21 days a commercially prepared diet either lacking or supplemented with pyridoxine. They were then inoculated with tumor cells in the hind legs and divided into 4 groups: Group A was continued on the deficient diet; group B was changed to the control diet and pair-fed to group A; group C was changed to the control diet and fed ad libitum; and group D was fed the control diet ad libitum from the start of the test. Host livers and hepatomas were removed and weighed at death, and tyrosine transaminase specific activity levels were determined. The results showed that hepatomas grown in animals fed the vitamin-deficient diet weighed the least. The difference between average tumor weights of hepatomas from animals receiving the pyridoxine-supplemented diet either on a restricted (pair-fed) or ad-libitum basis and from animals fed the vitamin-deficient diet was highly significant (P<0.001). In all cases, pyridoxine reduced host liver enzyme levels. Animals bearing hepatomas #7777 and 7316B showed a similar specific enzyme activity pattern; however, the pattern was reversed in animals bearing #5123A and 7800 hepatomas; i.e., lower host liver enzyme levels were found than in respective tumors in the deficient state, whereas the opposite was true for the nondeficient (normal) state.
Endoscopic removal of a nasogastric tube accidentally ligated to the duodenum after open abdominal surgery
Authors: Su Kim, Jun-Won Chung, Jun-Young Yang
Journal: Endoscopy (2016)

A 61-year-old man underwent open abdominal surgery for primary repair of a duodenal perforation. Preoperatively, a nasogastric tube had been inserted into the stomach for decompression. An attempt was made to remove the tube 6 days postoperatively but this was not possible because of marked resistance. Upper gastrointestinal endoscopy revealed that the nasogastric tube and granulation tissue were intertwined with a 3-0 Vicryl suture at the second portion of the duodenum ([Fig. 1 a]).
Continuing education, recertification, and examination anxiety
Authors: E B Feigelson, W Frosch
Journal: American Journal of Psychiatry (1977)

A substantial majority of the 645 psychiatrists responding to a questionnaire survey favored mandatory continuing education and evidence of continuing education as a requirement for relicensure. The respondents' overwhelming repudiation of recertification may be based on examination anxiety. The respondents recognized the value of continuing education, were even willing to document it in order to be relicensed, but did not wish to examined. Those respondents who were younger, Board-certified, and had an academic appointment were more likely to favor continuing education requirements in order to be relicensed. Private practitioners were underrespresented among the respondents, highlighting the important role that APA and its district branches must play in developing meaningful continuing education opportunities for psychiatrists.
Male transsexuals in the homosexual subculture
Authors: E M Levine
Journal: American Journal of Psychiatry (1976)

The author describes 20 male transsexuals who differ from most discussed in professional studies and from those in media portrayals in that they live in the male homosexual subculture. Furthermore, interviews with these individuals indicated that transsexuals are no more sexually or socially homogeneous than heterosexuals or homosexuals. In general, these men entered the homosexual subculture in their teens; they knew they were not heterosexual and therefore assumed they must be homosexual. As their gender identity crystallized, homosexual activity became repugnant and they rejected and were rejected by male homosexuals. Being unable to attract heterosexual men, they sought bisexual partners in a futile effort to confirm their identity as females. The author suggests that in addition to efforts to help transsexuals shift their gender identity, psychiatrists should emphasize prevention of this psychopathologic symptom.
Long Term Outcomes of ERT in Children with Gaucher Disease. Spanish Experience
Authors: Marcio M Andrade, Pilar Alfonso, Pilar Irún, Javier Dalmau, Jose Luis Barbera, Horacio Cano, María Angeles Fernandez-Galan, Rafael Franco, Inmaculada Garcia, Angela IbaÃ±ez, Francisco Lendinez, Elena Martin-Hernandez, Luis Antonio Sancho-Val, Pablo Sanjurjo, Miguel Pocovi, Pilar Giraldo
Journal: Blood (2014)
PTH-201 Factors affecting the efficacy of needlefree connector disinfection: Abstract PTH-201 Table 1
Authors: M Small, D Robinson, S Patel
Journal: Gut (2015)

<h3>Introduction</h3> Needlefree connector contamination can lead to central venous catheter related bloodstream infection (CRBSI). Differences in connector design such as a smooth or irregular septum surface and/or a tight seal between the septum and the connector housing can impede disinfection. Disparity between protocols; disinfectant contact time, disinfection method (if the surface is wiped in one direction or back and forth) and inter rater variation may also affect results. This invitro study aimed to assess these variables on the macroscopic contamination of different connectors. <h3>Method</h3> The surfaces of 5 different needlefree connectors were contaminated with ultraviolet (UV) disclosing lotion (invisible to the naked eye). 3 raters subsequently wiped the connectors with 2% chlorhexidine and 70% isopropyl alcohol wipes using a friction rub for 0 (control) 3, 5, 15 and 30 secs. Using UV light the amount of residual lotion on the connectors was assessed and scored accordingly; 100 if there was no trace of lotion, 75 a minimal trace, 50 a moderate trace and 25 if a large trace remained. These values were decided by 2 raters. The procedure was then repeated following the application of 70% isopropyl alcohol port protection caps to the connector for 5 min before disinfection. <h3>Results</h3> The mean score ±standard deviation from all connectors and all raters is shown below. Variation between devices was significant p &lt; 0.0001. Higher scores were obtained when port protection was applied pre disinfection vs. no port protection. The difference between these was significant p &lt; 0.0001. The mean score for disinfecting &lt;10secs was 69 ± 23.4 vs. 83 ± 17.7 for &gt;10 secs. This difference was significant p &lt; 0.0001. There was a difference between 3 and 5 secs; 65 ± 24 vs. 74 ± 22, p = 0.03, but no difference between 15 vs. 30 secs; 82 ± 17.9 vs. 83 ± 17.7, p = 0.6. The scores from the 3 raters were 78 ± 21 vs. 78 ± 19.9 vs. 70 ± 23 respectively. Variation between raters was significant p = 0.01. There was no difference between raters when the port protector was applied pre disinfection p = 0.19. <h3>Conclusion</h3> The results from this study demonstrated differences in the removal of macroscopic contamination from needlefree connectors. These differences most likely reflect variation in the surface topography of the individual connectors. Disinfecting for 10 secs or more was more effective than less than 10 secs, with 15 secs being as effective as 30 suggesting a minimum of 15 secs is sufficient. There was variation between raters but this was minimised by using a 70% isopropyl alcohol port protector. The extent to which these results could impact upon the development of CRBSI will be the focus of future study. <h3>Disclosure of interest</h3> None Declared.
Histochemical and Morphologic Differentiation of Induced Tumors of the Liver in Rats
Authors: Harlan I. Firminger, Ambadas S. Mulay
Journal: JNCI Journal of the National Cancer Institute (1952)

Histochemical and Morphologic Differentiation of Induced Tumors of the Liver in Rats Harlan I. Firminger, Harlan I. Firminger Laboratory of Pathology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Ambadas S. Mulay Ambadas S. Mulay Laboratory of Pathology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar 2Present address: Department of Pathology and Oncology, University of Kansas Medical Center, Kansas City 12, Kans. 3National Institutes of Health, Public Health Service, Federal Security Agency. Author Notes JNCI: Journal of the National Cancer Institute, Volume 13, Issue 1, August 1952, Pages 19–33, https://doi.org/10.1093/jnci/13.1.19 Published: 01 August 1952 Article history Received: 29 February 1952 Published: 01 August 1952
More problems with the new junior doctor contract
Authors: Hugo Farne
Journal: BMJ (2015)

Bagenal and colleagues’ editorial overlooks one of the most sinister aspects of the proposed junior doctors’ contract: the removal of safeguards against working excessive hours.1 Currently junior doctors’ hours are routinely audited and hospital trusts are penalised financially if doctors are coerced into staying beyond their contracted hours. The proposed contract has no penalties for trusts and hence no teeth. Moreover, junior …
A MODEL FOR DISEASE HETEROGENEITY IN SYSTEMIC LUPUS ERYTHEMATOSUS: Relationships Between Histocompatibility Antigens, Autoantibodies, and Lymphopenia or Renal Disease
Authors: John B. Harley, Andrea L. Sestak, Larry G. Willis, Shu Man Fu, John A. Hansen, Morris Reichlin
Journal: Arthritis & Rheumatology (1989)

We composed a model from autoimmune serologic findings, HLA antigens, and clinical findings that explains, at least partially, the clinical heterogeneity of 40 patients with systemic lupus erythematosus (SLE). In these patients, anti-RO (SS-A) was related to the HLA-DQ1/DQ2 heterozygotes, anti-La (SS-B) was related to HLA-B8 and HLA-DR3, and anti-nuclear RNP (Sm) was related to HLA-DR4. Lymphopenia was associated with anti-Ro (SS-A) and, secondarily, with anti-single-stranded DNA. Renal disease in these SLE patients was inversely associated with anti-La (SS-B) and was positively associated with anti-double-stranded DNA. There were no associations between the HLA antigens and these clinical manifestations. The results support a model of disease expression in which individuals are nonspecifically potentiated for SLE. Their HLA antigen composition influences the production of particular autoantibodies that are related in complex ways to the different particular clinical findings of SLE manifested in individual patients.
Cardiopulmonary Monitoring of Critically Ill Patients
Authors: Paul D. Goldenheim, Homayoun Kazemi
Journal: New England Journal of Medicine (1984)

THE purpose of this review is to examine some of the more important and commonly used methods of monitoring heart and lung function in critically ill patients in an adult medical-intensive-care unit. We will attempt to review the literature and discuss the indications, risks, and benefits of the important invasive methods of cardiopulmonary monitoring. First, however, it is appropriate to review the available noninvasive means of monitoring heart and lung function, which provide important information about patient care and, in many instances, may obviate the need for invasive procedures.General ConsiderationsA general outline for the evaluation of heart and . . .
The Research Grants Branch of the National Cancer Institute
Authors: Ralph G. Meader, O. Malcolm Ray, Donald T. Chalkley
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article The Research Grants Branch of the National Cancer Institute Get access Ralph G. Meader, Ralph G. Meader Research Grants Branch, National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar O. Malcolm Ray, O. Malcolm Ray Research Grants Branch, National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald T. Chalkley Donald T. Chalkley Research Grants Branch, National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 2, August 1957, Pages 225–258, https://doi.org/10.1093/jnci/19.2.225 Published: 01 August 1957