tbuckley/cabot-search huggingface dataset:
Use of a structured diagnostic interview to identify bipolar disorder in adolescent inpatients: frequency and manifestations of the disorder
Authors: G D Gammon, K John, E D Rothblum, K Mullen, G L Tischler, M M Weissman
Journal: American Journal of Psychiatry (1983)

The authors interviewed 17 adolescent inpatients and their mothers with the Schedule for Affective Disorders and Schizophrenia for School-Aged Children and Adolescents, Epidemiological Version (K-SADS-E), a semistructured interview that generates RDC and DSM-III diagnoses for major affective disorders and nonaffective psychoses and DSM-III diagnoses for dysthymic, cyclothymic, and other selected disorders. Five of the patients (29%) satisfied DSM-III criteria for bipolar disorder or atypical bipolar (bipolar II) disorder, although these diagnoses had not been identified in the hospital charts. These data support previous findings that bipolar disorder occurs moderately frequently in adolescent inpatients, although it is often unrecognized. Moreover, the disorder can be readily identified with structured diagnostic methods.
Valproic Acid
Authors: Jan Koch-Weser, Thomas R. Browne
Journal: New England Journal of Medicine (1980)

Valproic acid (VPA) is an antiepileptic drug approved in 1978 by the United States Food and Drug Administration (FDA) for the treatment of absence seizures. VPA is a simple eight-carbon branched-chain fatty acid, which is structurally unrelated to any other marketed drug (Fig. 1). In the United States, tablets are marketed as VPA, and syrup is marketed as the sodium salt of VPA (sodium valproate). Tablets of the sodium and magnesium salts of VPA and an amide form of VPA are marketed in some foreign countries.Mechanism of ActionVPA suppresses seizure activity in many animal models of epilepsy and . . .
Gas gangrene and hyperbaric oxygen.
Authors: P Houriet
Journal: BMJ (1972)

From 1964-1987 we have examined 31 patients suspected to have gaseous gangrene. The diagnosis was confirmed 13 times on clinical and microbiologic grounds. 61% of the patients underwent amputation, 28% died. On the basis of this experience we have tried to define a therapeutic attitude. We recommend an adequate debridement, i.e. the removal of necrotic tissue and drainage of the wound, microbiological investigations and the administration of antibiotics before hyperbaric oxygen treatment is begun (2-3 treatments over 3 days).
Global productivity of dermatological research: a bibliometric analysis from 1985 to 2014
Authors: S.‐Y. Chen, J.‐T. Wu
Journal: British Journal of Dermatology (2016)

Bibliometrics is the quantitative study of literatures according to bibliographies, intended to provide evolutionary models of science, technology, and scholarship through an objective evaluation of the performance and impact of research activity in the studied field (1). In recent years, bibliometric methods have been increasingly used to evaluate scientific production in numerous medical fields, including anesthesiology, ophthalmology, psychiatry and orthopedics (2)(3)(4)(5).

This article is protected by copyright. All rights reserved.
EPT-16A PHASE 1 TRIAL OF LENALIDOMIDE PLUS RADIOTHERAPY IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMAS OR HIGH-GRADE GLIOMAS
Authors: Sean Hipp, Stewart Goldman, Aradhana Kaushal, John Glod, Joanna Shih, James Garvin, Matthias Karajannis, Mark Atlas, Kevin Camphausen, Roger Packer, Kathy Warren
Journal: Neuro-Oncology (2016)
Why vessels do matter in pulmonary disease
Authors: Jurjan Aman, Harm Jan Bogaard, Anton Vonk Noordegraaf
Journal: Thorax (2016)

In addition to structural abnormalities of the diaphragm, congenital diaphragmatic hernia (CDH) presents with severe hypoplasia of lung tissue involving both the pulmonary vasculature and the airways. These developmental defects often yield a severe phenotype of pulmonary hypertension (PH) and lung function impairment. Despite adequate surgical repair of the diaphragm, neonatal mortality of CDH remains high, due to ineffectiveness of inhaled nitric oxide (NO) and absence of alternative therapy for PH in the newborn.

Russo et al 1 demonstrate that maternally administered sildenafil reaches therapeutic levels in the rabbit fetus, without toxicity for mother or the fetus. CDH fetuses treated with sildenafil demonstrated increased pulmonary vascular branching compared with placebo-treated fetuses. The improved vascularisation was paralleled by reduced pulmonary artery pressure and by morphological changes in the lung parenchyma and functional improvement. In line with previous rodent studies, Russo et al 1 found that the decreased lung weight due to CDH is not rescued in sildenafil-treated fetuses with CDH, suggesting that the sildenafil-induced improvement of vascular and alveolar development contributes to the lung maturation more than the volume growth. These well-performed studies obtained in an animal model that closely resembles both the pharmacokinetics of human pregnancy and alveolar development in humans provide a next step towards a clinically useful therapy for CDH and its postnatal consequences.

In addition to providing relevant steps towards clinical development of sildenafil as a potential therapy for CDH, Russo et al give valuable insights into the mechanisms of lung development. Stressing the key role of cyclic guanosine monophosphate (cGMP)/NO signalling in …
QOS-13LANGUAGE PROCESSING IN MONOLINGUAL AND BILINGUAL CHILDREN DIAGNOSED WITH MEDULLOBLASTOMA
Authors: Grace Mucci, Tara DeLuco, Gabriella Santacruz, Lara C.K. Tucci, Adrianne Alpern, Jody Pathare, Tina Templeman, Cristian Gallagher, Violet Shen
Journal: Neuro-Oncology (2016)

Cognitive impairment is a significant comorbidity in children with posterior fossa brain tumors.Several studies have found that the functional brain organization of bilinguals and monolinguals have distinct and shared sites that support language.This retrospective study aims to examine the posttreatment performance on language tasks of monolingual (N ¼ 9) and
Abstract 5853: Continuous Flow Left Ventricular Assist Device in Women with Advanced Heart Failure: Results After One Year of Support
Authors: Salpy V Pamboukian, Roberta C Bogaev, Stuart D Russell, Andrew J Boyle, Nader Moazami, Leway Chen, David J Farrar, Francis D Pagani
Journal: Circulation (2008)

Small continuous flow left ventricular assist devices (LVAD) are providing new options for women in advanced heart failure who due to body size limitations were historically excluded from use of large first generation pulsatile devices. We report the experience of women one year after implantation with the new, HeartMate II continuous flow LVAD for bridge to transplantation. Patients (n=279), 24% female (F), 76% male (M) in NYHA Class IV heart failure, LV ejection fraction 16±7% (F), 16±6% (M), mostly inotrope dependent and about half on intraaortic balloon pump support (50% F, 43% M), who had been enrolled in the HM II clinical trial for at least 1 year as a bridge to cardiac transplantation at 33 centers were analyzed. Outcomes and causes of death in the first year of support between F and M recipients were determined. The percentage of patients who had undergone transplantation, recovery of the heart with device removal, or continued on HM II support after one year were the same (80%) between M and F. However, the percentage of patients who had received a heart transplant was significantly less for F (38%) than M (53%) (p&lt;0.05). Median duration of support for F was 226 days (range 8–1004) vs. 143 days (range 0–1057) for M. Mortality on device support was 20% for F and 18% M. There were no statistically significant differences in leading causes of death: sepsis (1.5% F vs 4.2% M), ischemic stroke (3.1% F vs 1.9% M), hemorrhagic stroke (3.1% F vs 1.4% M), and right heart failure (3.1% F vs 1.9% M). Of 82 patients continuing on support at 1 year, 26 (32%) were F with median BSA of 1.65 vs 2.14 m 2 for M. Kaplan Meier survival at one year was similar for females (74%) and males (76%). The smaller, more durable HM II rotary LVAD may be especially advantageous to women with advanced HF as a bridge to cardiac transplantation, because of significantly smaller BSA and need for extended duration of mechanical support due to longer wait times for suitable organ donors. Outcomes at one-year
AT-18INVESTIGATING THE BIOLOGY OF ATYPICAL TERATOID/RHABDOID TUMORS BY WHOLE GENOME CRISPR/CAS9 SCREENING
Authors: Matthew P. Selby, Martina A. Finetti, Matthew Bashton, Ruth E. Cranston, Alicia Del-Carpio-Pons, Simon Bailey, Steven C. Clifford, Daniel Williamson
Journal: Neuro-Oncology (2016)
DNMT3A Mutations In AML: Incidence, Prognostic Influence and Association With Other Molecular Markers
Authors: Igor Wolfgang Blau, Rimma Berenstein, Claudia D. Baldus, Sophie Schlabitz, Asiye Kar, Ruhiye Cay, Annette Sindram, Claudia Seide, Antonio Pezzutto, Bernd Dörken, Olga Blau
Journal: Blood (2013)
Treatment of cetuximab-associated cutaneous side effects using topical aplication oh vitamin K1 cream
Authors: J. Ocvirk, M. Rebersek
Journal: Journal of Clinical Oncology (2009)

e15087 Background: The EGFR-targeting monoclonal antibody cetuximab has been licensed by the EMEA in combination with chemotherapy for the treatment of 1 st line metastatic colorectal cancer (mCRC) patients (pts) whose tumors have KRAS wild type status. The major side effects of cetuximab are cutaneous reactions (approx. 80% of pts.) predominantly consisting of an acne- like rash 60–100%, but also including pruritus, dry skin (35%), desquamation, hypertrichosis and nail disorders (10–40%). If not properly managed, they have the potential to cause dose reductions and delays, which may in turn impact on treatment efficacy. The aim of our study was to determine the efficacy of topical vitamin K1 cream in pts with cutaneus side effects caused by cetuximab therapy. Methods: Between January 2007 and August 2008, 79 pts with mCRC were treated with weekly cetuximab in combination with chemotherapy. Topical use of a cream containing urea and 0.1% vitamin K1 was applied when an acne-like rash (NCI CTCAE version 3) appeared . Pts were monitored weekly for at least 12 weeks. Results: Sixty nine patients developed an acne-like rash after a median of 1.2 weeks after first cetuximab administration (range 1- 4), 20 pts grade 3, 38 grade 2 and 11 grade 1. Twice-daily application of vitamin K1 cream resulted in a gradual decrease in cutaneous toxicity. Median time to improvement (all toxicity grades) was 1.2 weeks and 2.3 weeks to a down-staging of the rash by at least 1 grade. Dose reduction of cetuximab was necessary for only 5 of the 20 pts with grade 3 toxicity. No dose reductions or treatment delays were needed for any patient with grade 1 or 2 cutaneous toxicity. Topical clindamycin was used concomitantly in 12/20 and 2/38 pts with grade 3 and grade 2 reactions respectively. No toxicity was associated with the topical use of vitamin K1cream. Conclusions: This study demonstrated the efficacy of topically applied vitamin K1 containing cream in the management of cetuximab-induced acne-like skin rash. No significant financial relationships to disclose.
Screening of Blood Donations for Zika Virus Infection — Puerto Rico, April 3–June 11, 2016
Authors: Matthew J. Kuehnert, Sridhar V. Basavaraju, Robin R. Moseley, Lisa L. Pate, Susan A. Galel, Phillip C. Williamson, Michael P. Busch, Jose O. Alsina, Consuelo Climent-Peris, Peter W. Marks, Jay S. Epstein, Hira L. Nakhasi, J. Peyton Hobson, David A. Leiby, Pradip N. Akolkar, Lyle R. Petersen, Brenda Rivera-Garcia
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Transfusion-transmitted infections have been documented for several arboviruses, including West Nile and dengue viruses (1). Zika virus, a flavivirus transmitted primarily by Aedes aegypti mosquitoes that has been identified as a cause of congenital microcephaly and other serious brain defects (2), became recognized as a potential threat to blood safety after reports from a 2013-2014 outbreak in French Polynesia. Blood safety concerns were based on very high infection incidence in the population at large during epidemics, the high percentage of persons with asymptomatic infection, the high proportion of blood donations with evidence of Zika virus nucleic acid upon retrospective testing, and an estimated 7-10-day period of viremia (3). At least one instance of transfusion transmission of Zika virus has been documented in Brazil after the virus emerged there, likely in 2014 (4). Rapid epidemic spread has followed to other areas of the Americas, including Puerto Rico.
Tula hantavirus infection in a hospitalised patient, France, June 2015
Authors: Jean Marc Reynes, Damien Carli, Nourredine Boukezia, Monique Debruyne, Samir Herti
Journal: Eurosurveillance (2015)

We report an infection with Tula virus in June 2015, leading to hospitalisation, in a patient living approximately 60 km east of Paris with no previous remarkable medical history. Clinical symptoms were limited to a fever syndrome with severe headache. The main laboratory findings included thrombocytopenia and elevated transaminase levels. Based on S (small) gene sequence analysis, the strain affecting the patient was closely related to strains detected in Central Europe, especially to a south-east German strain.
CR-05NONALCOHOLIC FATTY LIVER DISEASE AND FATIGUE IN LONG-TERM SURVIVORS OF CHILDHOOD-ONSET CRANIOPHARYNGIOMA
Authors: Anika Hoffmann, Klaus Bootsveld, Ursel Gebhardt, Anna M. Daubenbüchel, Anthe S. Sterkenburg, Hermann L. Müller
Journal: Neuro-Oncology (2016)
30-Day Readmission Rate—A Blunt Instrument That Needs Honing
Authors: Alexander C. Schwed, Christian de Virgilio
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Calcium antagonists in the treatment of Tourette's disorder
Authors: T L Walsh, B Lavenstein, W L Licamele, S Bronheim, J O'Leary
Journal: American Journal of Psychiatry (1986)

Two patients with Tourette's disorder were treated with calcium antagonists. Verapamil and nifedipine produced positive responses, and diltiazem produced no response. Given the negative side effects of the current drugs for this disorder, the authors suggest further study of calcium antagonists.
Transmission of the L-Zagreb mumps vaccine virus, Croatia, 2005-2008
Authors: B Kaic, I Gjenero-Margan, B Aleraj, S Ljubin-Sternak, T Vilibić-Čavlek, S Kilvain, I Pavic, D Stojanovic, A Ilic
Journal: Eurosurveillance (2008)

We report on three cases of symptomatic transmission of the L-Zagreb mumps vaccine virus from three vaccinated children to five adult contacts. The five contact cases were parents of the vaccinated children and presented with parotitis and in one case also with aseptic meningitis. The etiology of the contacts' illness was determined by viral culture, genomic sequencing, serology and epidemiological linking. Two of the vaccinated children developed vaccine associated parotitis as an adverse event three weeks following immunization. Symptoms in contact cases developed five to seven weeks after the vaccination of the children. The five contact cases, as well as the three children with adverse events recovered completely. The children had been vaccinated with MMR vaccine produced by the Institute of Immunology Zagreb, each of them with a different lot. One of the possible explanations for these adverse events is that the very low levels of wild mumps virus circulation in the last decade, combined with waning immunity in those who received one dose of vaccine or suffered from mumps in childhood, resulted in susceptible young adults and that this unique epidemiological situation allows us to detect horizontal transmission of mumps vaccine virus.
Chemoprophylaxis and Treatment of Malaria
Authors: S J Rogerson, B A Biggs, G V Brown
Journal: New England Journal of Medicine (1989)

Prevention of malaria morbidity relies on the use of personal protection from mosquito bites, appropriate chemoprophylactic drugs, and early investigation of symptoms in returning travellers. Malaria chemoprophylaxis must be tailored to the individual patient's travel and personal needs, and no chemoprophylaxis is completely effective. Chloroquine alone is adequate for those areas with P vivax, or sensitive P falciparum but in most circumstances the choice will be between mefloquine and doxycycline. The specific area visited, the time spent there and the individual's medical history will help determine the final choice.
Age-related myelin degradation burdens the clearance function of microglia during aging
Authors: Shima Safaiyan, Nirmal Kannaiyan, Nicolas Snaidero, Simone Brioschi, Knut Biber, Simon Yona, Aimee L Edinger, Steffen Jung, Moritz J Rossner, Mikael Simons
Journal: Nature Neuroscience (2016)
Training in geriatric psychiatry: will the supply meet the demand?
Authors: G W Small, K Fong, J C Beck
Journal: American Journal of Psychiatry (1988)

The number of geriatric patients with major psychiatric disorders is expected to grow along with the rising proportion of people age 65 and older. Despite recognition of this growth and increases in the training of geropsychiatrists, the supply of specialists is unlikely to keep up with the demand. The authors argue for greater resource expenditure in fellowship programs and a focus on training academic leaders to serve as role models for general psychiatrists and other primary care givers.
Pancreatic melanoma metastasis diagnosed by endoscopic ultrasound-guided SharkCore biopsy
Authors: Elena Nadal, Patrizia Burra, Claudia Mescoli, Laura Albertoni, Cosimo Sperti, Giacomo Sturniolo, Alberto Fantin
Journal: Endoscopy (2016)

Metastatic cancers make up fewer than 2 % of pancreatic malignancies, and the majority of them mimic a primary adenocarcinoma [1]. Limited data are available concerning the assessment of pancreatic secondary cancers using endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) [2]. In this study we report the first case of metastatic pancreatic melanoma to be diagnosed by combining EUS with biopsy sampling using the SharkCore needle (SharkCore Fine Needle Biopsy System, Covidien IIc, Newton Massachusetts, USA).
HG-69CELL CULTURE CONDITIONS AFFECT DIFFUSE INTRINSIC PONTINE GLIOMA EPIGENETICS AND RESPONSE TO THERAPEUTIC AGENTS
Authors: Sama Ahsan, Michael Haffner, Hiroaki Miyahara, Manabu Natsumeda, Yang Liu, Lauren Rocco, Charles Eberhart, Eric Raabe
Journal: Neuro-Oncology (2016)
Editor’s Note
Authors: Ramachandran S. Vasan
Journal: Circulation (2010)

American Heart Association statistics indicate that every 25 seconds an American has a coronary event, every 40 seconds someone has a stroke; every 38 seconds someone dies of cardiovascular disease (CVD), and every minute someone dies of a coronary event.These events are often without warning, with the first manifestation being catastrophic (ie, sudden death).Survivors are left with considerable morbidity.These stark numbers emphasize the importance and urgency of preventing CVD.One component of preventing CVD is to identify and target those at highest risk of disease.Thus, "risk prediction" is one of the central tenets of preventing CVD.The recent decade has seen major advances in our understanding of the pathophysiology of CVD, and a plethora of biomarkers (both circulating and genetic ones; proteomic, lipidomic, metabolomic biomarkers, and small molecules/cells) have emerged as playing a key role in determining the onset of CVD.These novel biomarkers have become candidates for CVD prediction.In parallel, there has been a burgeoning growth in the number of CVD prediction algorithms, accompanied by important advances in assessing which metrics to use to evaluate increments to contemporary CVD risk prediction tools.The purpose of this series of articles in Circulation is to elucidate these advances in CVD risk prediction systematically.The series begins with an elaboration of the basic concepts of risk prediction, including the different time horizons of risk prediction (short-term, long-term, lifetime), and an interpretation of relative and absolute risks of disease.We also explore how the explosion of genomics and systems biology (OMICS) has led to the inundation of the literature with so many biomarkers, and how best to synthesize a parsimonious set of predictors from the numerous eligible and worthy candidates.We explore separately the expectations from and the incremental contribution of novel biomarkers to risk prediction in the primary and secondary prevention settings, where the goals of prediction may be distinct.One of the articles directly discusses how different the various contemporary risk prediction algorithms are from each other, and evaluates if these risk assessment scores truly make a difference in practical terms of patient management and disease outcomes.Last but not least, in this series we explore the standards for evaluating the clinical utility of new biomarkers (including an assessment of their costeffectiveness) with a focus on optimal study designs to address this important issue.In summary, this series of articles on risk prediction presents the state-of-the-current-art of CVD risk prediction in primary and secondary prevention settings, outlines the future ahead of us in terms of personalized risk prediction, and clarifies the desirable designs and standards for measuring clinical utility of new biomarkers of CVD risk.
Foreign medical graduates and board certification: myths and realities
Authors: E Val, S Quick
Journal: American Journal of Psychiatry (1983)

The participation of foreign medical graduates (FMGs) in American medicine is a longstanding phenomenon, yet the documentation of their role has been mainly impressionistic and anecdotal, particularly in psychiatry. Using the results of a survey on Board certification, the authors compared FMGs with U.S. medical graduates (USMGs) on several variables: demographic characteristics, attitudes toward certification, performance, and personal experience with the examination process. They found that FMGs are more similar than dissimilar to USMGs in attitudes, values, and opinions about certification. The authors conclude that the differences are not sufficiently remarkable to warrant some of the prevalent misconceptions about FMGs.
GC-20THE CHILDREN'S ONCOLOGY GROUP (COG) CURRENT TREATMENT APPROACH FOR CHILDREN WITH NEWLY DIAGNOSED CENTRAL NERVOUS SYSTEM (CNS) NON-GERMINOMATOUS GERM CELL TUMORS (NGGCTs)
Authors: Girish Dhall, Shengjie Wu, Soumen Khatua, Ute Bartels, James Boyett, Jason Fangusaro
Journal: Neuro-Oncology (2016)