tbuckley/cabot-search huggingface dataset:
Improvement in quality of life and symptom control with MYCOBACTERIUM W (CADI-05) in head and neck cancer
Authors: R. I. Dave, U. B. Tripathi, B. J. Parikh, K. M. Patel, H. K. Shukla
Journal: Journal of Clinical Oncology (2007)

21186 Background: Recurrent, radiated and chemotherapy given patients are having many unmanageable symptoms and problems. This condition is worsened by malnutrion, infection, pain and immuno suppression. Modifying immune mechanism of the body is the last and best weapon to fight against such diseases. Role of immunotherapy in the treatment of malignant diseases is on experimental level. Dr George Thyphrontis &amp; Michael Kousilers have produced good results in carcinoma of urinary bladder, melanoma &amp; lung cancer with Immunotherapy. At GCRI, we have tried vaccine, prepared from mycobacterium-W in 100 cases of Head &amp; Neck Cancer. Methods: As a prospective nonrandomized study, to see beneficiary effect on quality of life and symptom control, we have done a trial during Jan. 2004 to Dec.2005. Informed consent and ethical clearance was obtained. Study was made to find out any side effect or adverse reactions of the vaccine. After fulfilling the criteria of inclusion and exclusion the case was selected for study and 0.1 ml vaccine (CADI-05) was injected intradermally with all aseptic precautions. Four injections, weekly and later on four injections monthly were given. Patient was followed up for 6 months. Results: Total No. of cases -100. M / F - 89/11. age distribution - Maximum No. were in 5 th decade -(34%) followed by 6 th decade (21%)Site of primary - Commonest site was Buccal mucosa (29%) followed by tongue (17%). There was no major side effect. Only 5% Patients developed constitutional symptoms and infection at injection site. 27% patients had pain relief. Symptom control was seen in 15% patients. Improvement in quality of life was observed in 82% of patients. 4% of patients had no effect. The beneficiary effect lasted for three month in 27% patients and more than six months in 13% patients. The effect was more marked in dysphagia, ulcer and fistula. Effect was insignificant in strider, change in voice and metastatic nodes. Four patients are living with Immuvac in spite of disease symptom free for more than one year. Conclusions: Immunotherapy with Mycobacteium W can safely be used to improve quality of life and control of symptom in terminally ill Head &amp; Neck cancer. No significant financial relationships to disclose.
Case 13-1978
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, C. Thomas Griffiths, Stanley J. Robboy
Journal: New England Journal of Medicine (1978)

Presentation of Case First admission. A 53-year-old woman was admitted to the hospital because of disseminated intravascular coagulation.She was well until one month earlier, when she entered another hospital because of deep thrombophlebitis of the left leg. Anticoagulant treatment was given, but hematuria developed. After the therapy was discontinued signs of deep thrombophlebitis appeared in the right leg; heparin was administered, with improvement. After discontinuance of heparin the patient was found to have a prolonged partial thromboplastin time, diminished fibrinogen and an elevated titer of fibrin-split products. Heparin therapy was resumed, and she was transferred to this hospital. . . .
Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension
Authors: Sílvia Vilarinho, Sinan Sari, Güldal Yilmaz, Amy L. Stiegler, Titus J. Boggon, Dhanpat Jain, Gulen Akyol, Buket Dalgic, Murat Günel, Richard P. Lifton
Journal: Hepatology (2016)

Despite advances in the diagnosis and management of idiopathic noncirrhotic portal hypertension, its pathogenesis remains elusive. Insight may be gained from study of early-onset familial idiopathic noncirrhotic portal hypertension, in which Mendelian mutations may account for disease. We performed exome sequencing of eight subjects from six kindreds with onset of portal hypertension of indeterminate etiology during infancy or childhood. Three subjects from two consanguineous families shared the identical rare homozygous p.N46S mutation in DGUOK, a deoxyguanosine kinase required for mitochondrial DNA replication; haplotype sharing demonstrated that the mutation in the two families was inherited from a remote common ancestor. All three affected subjects had stable portal hypertension with noncirrhotic liver disease for 6-16 years of follow-up. This mutation impairs adenosine triphosphate binding and reduces catalytic activity. Loss-of-function mutations in DGUOK have previously been implicated in cirrhosis and liver failure but not in isolated portal hypertension. Interestingly, treatment of patients with human immunodeficiency viral infection with the nucleoside analogue didanosine is known to cause portal hypertension in a subset of patients and lowers deoxyguanosine kinase levels in vitro; the current findings implicate these effects on deoxyguanosine kinase in the causal mechanism.Our findings provide new insight into the mechanisms mediating inherited and acquired noncirrhotic portal hypertension, expand the phenotypic spectrum of DGUOK deficiency, and provide a new genetic test for a specific cause of idiopathic noncirrhotic portal hypertension. (Hepatology 2016;63:1977-1986).
Genetic analyses of GII.17 norovirus strains in diarrheal disease outbreaks from December 2014 to March 2015 in Japan reveal a novel polymerase sequence and amino acid substitutions in the capsid region
Authors: Y Matsushima, M Ishikawa, T Shimizu, A Komane, S Kasuo, M Shinohara, K Nagasawa, H Kimura, A Ryo, N Okabe, K Haga, Y H Doan, K Katayama, H Shimizu
Journal: Eurosurveillance (2015)

Binary file ES_Abstracts_Final_ECDC.txt matches
Dystocia from Relative Shortness of the Funis
Authors: J. A Lycett
Journal: BMJ (1897)

A MAN, aged 30, who had sustained a double Colles's fracture, was sent to me by Dr. Cresswell, House-Surgeon to the in- firmary, to be skiagraphed, on September gth.The deformity was of the usual character in both limbs, and the cause of the injuries was a fall from a height upon the palm of the extended hands.It will be observed that the bone lesions of the radii of a clinical entity are dissimilar, but the point I would like to draw special attention to is to the fracture of the styloid pro- cesses of both ulnme, with the hope that others who have the
Conflict of Interest
Authors: Cheryl Dellasega
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Association of Leisure-Time Physical Activity With Risk of 26 Types of Cancer in 1.44 Million Adults
Authors: Steven C. Moore, I-Min Lee, Elisabete Weiderpass, Peter T. Campbell, Joshua N. Sampson, Cari M. Kitahara, Sarah K. Keadle, Hannah Arem, Amy Berrington de Gonzalez, Patricia Hartge, Hans-Olov Adami, Cindy K. Blair, Kristin B. Borch, Eric Boyd, David P. Check, Agnès Fournier, Neal D. Freedman, Marc Gunter, Mattias Johannson, Kay-Tee Khaw, Martha S. Linet, Nicola Orsini, Yikyung Park, Elio Riboli, Kim Robien, Catherine Schairer, Howard Sesso, Michael Spriggs, Roy Van Dusen, Alicja Wolk, Charles E. Matthews, Alpa V. Patel
Journal: JAMA Internal Medicine (2016)

Leisure-time physical activity has been associated with lower risk of heart-disease and all-cause mortality, but its association with risk of cancer is not well understood.
Abstract B29: Characterization of the regulatory feedback program components after HER2 inhibition in breast cancer cells
Authors: Nareeza Sakur, Marc Fink
Journal: Cancer Research (2016)

Abstract HER2 overexpression drives tumorigenesis in a subset of breast cancers and pharmacological inhibition of this receptor tyrosine kinase is currently used in the clinic for these patients. While all of the cancer cells within the tumor are dependent on HER2 signaling, treatment with HER2 inhibitors results in the establishment of two separate populations; cells that undergo apoptosis and cells that survive. The mechanisms underlying the decision-making processes are not well understood. A proposed mechanism for establishing resistance within a population involves induction of signaling components that may allow for bypass of HER2. Induction of these genes is dependent on AKT inhibition and subsequent activation of the FOXO family of transcription factors. The best-studied adaptive signaling components relevant to HER2-positive breast cancer are HER3, IGF1R, and IR. The involvement of these signaling components in acute adaptive resistance to HER2 inhibition was studied in the HER2-positive BT474 cell line. Lapatinib increased HER3 protein levels in a concentration dependent manner, however, at higher concentrations this effect was reversed. In contrast, inhibition of PI3K increased HER3 levels even at higher concentrations. Time course analysis of HER3 induction demonstrated strong regulation of protein levels at 8 hours post addition of inhibitor. Ongoing work is focused on determining whether these findings are generally applicable to the adaptive gene response. The results reported here provide a framework to model the effects of HER2 inhibition on apoptosis and survival in breast cancer cells. Citation Format: Nareeza Sakur, Marc Fink. Characterization of the regulatory feedback program components after HER2 inhibition in breast cancer cells. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr B29.
Gvhd-Associated Early Impairment of Marrow Function Is Frequent after Allogeneic Transplantation and Is a Sensitive Biomarker for Prediction of Treatment Related Mortality and of Overall Survival
Authors: Giuseppe Milone, Giuseppe Avola, Maria Grazia Camuglia, Salvatore Leotta, Alessandra Cupri, Andrea Spadaro, Giovanni Tripepi
Journal: Blood (2014)
Reported cases of congenital syphilis in the French national hospital database
Authors: N Nicolay, A Gallay, A Michel, J Nicolau, J  C Desenclos, C Semaille
Journal: Eurosurveillance (2008)

In France, the resurgence of syphilis infection since the beginning of the 2000s, with cases reported among women of reproductive age is a reason for concern considering the possible occurrence of congenital syphilis (CS). Using the French national private and public hospital database, we investigated the number of children with a diagnosis of CS born in France in 2004. Six cases less than one year old were identified as probable CS in the database. Two of these cases were adopted children from outside Europe, whereas the other four were born in France. The mothers of these last four infants tested positive for syphilis during the third trimester of pregnancy, two of them during premature delivery. Three of the four mothers were born abroad. Specific socio-cultural conditions may have been responsible for a lack of antenatal care responsible for the disease. Since CS is a preventable disease and the treatment of syphilis infection is cost-effective, we conclude that surveillance of CS cases and assessment of syphilis screening practises during pregnancy should be performed to prevent the occurrence of CS cases in France.
Abstract IA17: Collective epithelial routes to metastatic spread
Authors: Andrew J. Ewald
Journal: Cancer Research (2016)

Abstract The spread of cancer to distant organs is the major driver of mortality in cancer and, unfortunately, few therapies are effective in patients with extensive metastatic disease. Our hypothesis is that deeper mechanistic insight into the biological basis of metastasis will lead to novel therapeutic concepts. We have focused our laboratory investigations on understanding how epithelial cells acquire the ability to release their connections with their neighbors, migrate through the stroma, and enter the systemic circulation. The prevailing model when we began was the epithelial to mesenchymal transition (EMT), which posited a loss of epithelial features in the cancer cells during metastasis. The EMT model was controversial, in part because metastatic tumors typically retain many epithelial features. However, it remained possible that epithelial features were lost during stages of transit that are difficult to impossible to observe in vivo. To distinguish these possibilities, we developed novel 3D organoid assays to model normal epithelial growth, to determine the molecular requirements for Twist1 induced dissemination and to identify molecular programs driving the colonization of distant organs. The conclusions drawn across these studies are (1) that there are normal epithelial migratory programs that can be rapidly co-opted through activation of RTK signaling, (2) that the epithelial cell adhesion machinery can facilitate dissemination, and (3) that clusters of breast cancer cells utilize epithelial-specific gene expression (e.g. keratin-14) as they invade, disseminate, and colonize distant organs. These insights lead us to view metastasis as a process that can be accomplished without loss of epithelial character and that these epithelial routes to metastasis may have unique vulnerabilities compared to EMT models. We will discuss the latest progress in these studies and also technical advances in 3D culture that will accelerate metastasis research across organ sites. Citation Format: Andrew J. Ewald. Collective epithelial routes to metastatic spread. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA17.
National Cancer Institute Training Programs
Authors: Margaret H. Edwards
Journal: JNCI Journal of the National Cancer Institute (1975)

Journal Article National Cancer Institute Training Programs Get access Margaret H. Edwards, M.D. Margaret H. Edwards, M.D. Chief, Education Branch Division of Cancer Research Resources and Centers National Cancer Institut Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 55, Issue 4, October 1975, Pages 1023–1026, https://doi.org/10.1093/jnci/55.4.1023 Published: 01 October 1975
The Obesity Paradox and Mortality After Colorectal Cancer
Authors: Andrew G. Renehan, Matthew Sperrin
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
AB1183 Joint Operations as an Indicator of Disease Severity and Burden in the Quest-RA Study: Table 1.
Authors: T. Sokka, N. Khan, E. Nikiphorou, S. Verstappen, M. Hetland, N. Inanc, I. Laurindo, S. Stropuviene, B. Combe, M. Cutolo, J. Jacobs
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Joint replacement surgery represents a remarkable mile stone in the care of patients with rheumatoid arthritis (RA), aimed at improving patients9 functional capacity and reducing pain. Prior to current therapeutic strategies, surgical joint intervention was a frequent event. Currently, orthopedic surgery is considered as a surrogate marker of failed medical treatment and joint destruction. <h3>Objectives</h3> To compare disease burden in RA patients with and without major joint operation (MJO) in the QUEST-RA study. <h3>Methods</h3> Consecutive unselected patients with RA receiving usual rheumatology care were included in QUEST-RA study between 2005 and 2012 in 107 clinics in 34 countries (16 with low and 18 with high Gross Domestic Product, GDP, cut at 20,000$/person at the year of enrollment). The review included history of MJO: total joint replacement or fusion of hips, knees, shoulders, elbows, ankles, wrists, and the atlantoaxial joint. Clinical data at the cross sectional visit included disease activity based on DAS28(ESR, 3 variables) and patient reported outcomes (PROs) for disease burden (pain, global health, fatigue on 0-10cm VAS and HAQ on 0-3). Mean values of these variables were compared using parametric statistics in patients with or without history of MJO, according to disease duration (5-10 vs. &gt;10 years), adjusted for age and sex, in countries with low vs. high GDP. <h3>Results</h3> QUEST-RA includes 10,142 patients; joint operation data were available in 9069 patients (81%Female, mean age 55, median disease duration from symptom-onset 12 years, 74% RF+). Proportion of RA patients with a history of MJO was more than two times in high GDP countries [12.9% (663/5158)] compared to low GDP countries [5.8% (227/3911)] despite the latter having higher disease activity and worse PROs. Disease burden was higher in patients with a history of MJO across the groups (Table) except in patients with shorter disease duration 5-10 years in low GDP countries (all comparisons p=ns, data not shown). <h3>Conclusions</h3> In the real world setting in 2005-2012, history of MJO in patients with RA indicated higher disease burden and severity compared to patients without MJO. <h3>Disclosure of Interest</h3> None declared
Retrieval therapy for isolated CNS relapse in childhood acute lymphoblastic leukemia.
Authors: G K Rivera, R C Ribeiro, C H Pui
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.6.1528 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7751902 Retrieval therapy for isolated CNS relapse in childhood acute lymphoblastic leukemia. G K RiveraxG K RiveraSearch for articles by this author , R C RibeiroxR C RibeiroSearch for articles by this author , C H PuixC H PuiSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.6.1528 PDF "Retrieval therapy for isolated CNS relapse in childhood acute lymphoblastic leukemia.." Journal of Clinical Oncology, 13(6), pp. 1528–1529© 1995 by American Society of Clinical Oncology
P80 Extrapolating lung clearance index (LCI) from shortened measurements: Abstract P80 Table 1
Authors: K Tanou, S Irving, F Ahmad, L Fleming, M Rosenthal, A Bush
Journal: Thorax (2015)

<h3>Introduction and objectives</h3> Shortened multiple breath washouts (MBW) are attractive in young children, where a long test time may not be tolerable (Thorax 2013;68:586–7). Lung clearance index (LCI) is usually calculated at 1/40<sup>th</sup> of the starting concentration (LCI<sub>std</sub>), but in shorter MBWs the LCI is calculated at 1/20<sup>th</sup> of the starting concentration (LCI<sub>0.5</sub>). LCI<sub>0.5</sub> and LCI<sub>std</sub> are closely correlated but not interchangeable, and so we calculated an extrapolated full LCI (LCI<sub>ex</sub>) from LCI<sub>0.5</sub>. Our hypothesis was that extrapolated LCI (LCI<sub>ex</sub>) will better reflect LCI<sub>std</sub> than LCI<sub>0.5 </sub>and be more sensitive to intervention. <h3>Methods</h3> Condition-specific equations for cystic fibrosis (CF), primary ciliary dyskinesia (PCD) and asthma, and an overall equation for all 3 groups, were developed to convert LCI<sub>0.5</sub> to LCI<sub>ex</sub> from data previously analysed (n = 90, Thorax 2014;69[Suppl<sup>2</sup>]A166). LCI<sub>std</sub>, LCI<sub>0.5</sub> and LCI<sub>ex</sub> were then calculated for new cohorts (n = 70, 20 asthma, 30 CF, 20 PCD), and LCI<sub>ex</sub> was compared to LCI<sub>std</sub>. CF patients receiving IV antibiotics (n = 17) and asthma patients receiving triamcinolone (n = 32)) also had LCI<sub>std</sub>, LCI0.5 and LCI<sub>ex</sub> calculated and compared. The upper limit of normal for LCI<sub>std</sub> was calculated from healthy controls. LCI<sub>ex</sub> was compared to LCI<sub>std</sub> with a Bland-Altman plot. <h3>Results</h3> In CF, at higher LCIs, the spread between LCI<sub>ex </sub>and LCI<sub>std</sub> grew but there was no bias. For PCD and asthma agreement remained very good. There was no significant difference between LCI<sub>std</sub> and LCI<sub>ex</sub>. Results for positive and negative prediction of LCI<sub>std</sub> for LCI<sub>0.5</sub> and LCI<sub>ex</sub> are shown in the Table 1. LCI<sub>ex</sub> and LCI<sub>0.5</sub> were also sensitive to interventions in asthmatic and CF patients, although in general LCI<sub>std</sub> had better p values. <h3>Conclusions</h3> LCI<sub>ex</sub> performed better than LCI<sub>0.5</sub> in predicting results of LCI<sub>std</sub>. However, LCI<sub>ex</sub> did not always reflect LCI<sub>std</sub>, particularly in CF, so the two cannot be used interchangeably in lung disease.
THE EVOLUTION OF PREVENTIVE MEDICINE
Authors: A S WALLACE
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal