tbuckley/cabot-search huggingface dataset:
Abstract P6-12-06: Preoperative chemotherapy regimens and breast cancer subtype in an underinsured Hispanic population
Authors: D Mehta, L Winton, J Walters, C-H Hsu, J Nodora, ME Martinez, M Bouton, IK Komenaka
Journal: Cancer Research (2016)

Abstract Background: Although the Hispanic population is among the fastest growing in the United States, however, less is known about them then other populations. Breast cancer in different racial/ethnic populations display different behaviors. The current study was performed to examine response to preoperative chemotherapy regimen and by breast cancer subtype in a Hispanic safety net population. Methods: A retrospective review of Hispanic breast cancer patients who underwent preoperative chemotherapy from July 2001 to February May 2015 at a safety net hospital. Sociodemographic, clinical, and treatment variables were evaluated. Response to chemotherapy regimen was recorded. Breast cancer subtypes were divided based on IHC and FISH testing. Luminal B subtype was classified based on Ki67 (&amp;gt;15%) and PR (&amp;lt;20%). Results: The average age of the 133 patients was 45 years. 93% of the patients were insured with Medicaid or uninsured (70%). The average size of the cancers at presentation was 5cm. Overall 86% of patients had a clinical response to preoperative chemotherapy and 35% had pathologic complete response (pCR). AC and TC regimens had the lowest rate of pCR at 16%. AC/T (every 3 week and weekly) had similar rates of pCR 23% and 29%, while dose dense regimens showed pCR 40%. Herceptin containing regimens had pCR 57%. 7 patients received TAC and 71% had pCR. By subtype, Luminal A and B patients had low rates of pCR 9% and 14% respectively. Luminal B patients did benefit from preoperative chemotherapy as 86% of patients who were not candidates for breast conservation at presentation were able to undergo lumpectomy after preoperative chemotherapy. Her2 subtype patients who got Herceptin had pCR 57%. Triple negative patients had pCR 54%. Conclusions: In this underinsured, Hispanic population who presented at advanced stages, differences in response to preoperative chemotherapy were seen based on breast cancer subtype. Differences were also seen based on chemotherapy regimen. TAC maybe a particularly effective regimen in triple negative Hispanic women. Citation Format: Mehta D, Winton L, Walters J, Hsu C-H, Nodora J, Martinez ME, Bouton M, Komenaka IK. Preoperative chemotherapy regimens and breast cancer subtype in an underinsured Hispanic population. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-12-06.
Circulating Omentin as a Novel Biomarker for Colorectal Cancer Risk: Data from the EPIC–Potsdam Cohort Study
Authors: Krasimira Aleksandrova, Romina di Giuseppe, Berend Isermann, Ronald Biemann, Matthias Schulze, Clemens Wittenbecher, Andreas Fritsche, Rainer Lehmann, Juliane Menzel, Cornelia Weikert, Tobias Pischon, Heiner Boeing
Journal: Cancer Research (2016)

Omentin is a novel biomarker shown to exert metabolic, inflammatory, and immune-related properties and thereby could be implicated in the risk of colorectal cancer. So far, the association between omentin and colorectal cancer risk has not been evaluated in prospective cohort studies. We investigated the association between prediagnostic plasma omentin concentrations and risk of colorectal cancer in a case-cohort comprising 251 incident colorectal cancer cases diagnosed over a mean follow-up time of 10.4 years and 2,295 persons who remained free of cancer in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Hazard ratios as a measure of relative risk (RR) and 95% confidence intervals (CI) were computed using a Prentice-modified Cox regression. In a multivariable model adjusted for age, sex, education, dietary and lifestyle factors, body mass index (BMI), and waist circumference, higher omentin concentrations were associated with a higher colorectal cancer risk (RRcontinuously per doubling of omentin concentrations = 1.98; 95% CI, 1.45-2.73). Additional adjustment for metabolic biomarkers, including glycated hemoglobin, high-density lipoprotein cholesterol, and C-reactive protein, did not alter the results. In stratified analyses, the positive association between omentin and colorectal cancer risk was retained in participants with BMI < 30 (RRcontinuously per doubling of omentin concentrations = 2.26; 95% CI, 1.57-3.27), whereas among participants with BMI ≥ 30 no association was revealed (RRcontinuously per doubling of omentin concentrations = 1.07; 95% CI, 0.63-1.83; Pinteraction = 0.005). These novel findings provide the first lines of evidence for an independent association between prediagnostic omentin concentrations and colorectal cancer risk and suggest a potential interaction with the adiposity state of the individual. Cancer Res; 76(13); 3862-71. ©2016 AACR.
Steatosis induces significant, non-fibrosis related portal hypertension in association with signs of a hyperdynamic circulation and indicators of splanchnic vasodilation in vitro and in vivo in a rat model
Authors: Sven Francque, Isabelle Colle, Christophe Van Steenkiste, Shiama Chatterjee, Erick A. Van Marck, A. Herman, Paul Pelckmans, Peter P. Michielsen
Journal: Hepatology (2008)
Two cases of hypomania following the addition of L-tryptophan to a monoamine oxidase inhibitor
Authors: D C Goff
Journal: American Journal of Psychiatry (1985)

The combination of L-tryptophan and a monoamine oxidase inhibitor (MAOI) has been reported to be an effective antidepressant regimen. Neurotoxicity has previously been associated with this combination. The author presents two cases of hypomania following the addition of L-tryptophan to an MAOI.
KIT D816V Mutation Burden Predicts Prognosis and Survival In Patients With Mastocytosis and Correlates With The WHO Type Of The Disease
Authors: Gregor Hoermann, Karoline V. Gleixner, Graziella E. Dinu, Georg Greiner, Friedrich Wimazal, Emir Hadzijusufovic, Gerlinde Mitterbauer, Christine Mannhalter, Peter Valent, Wolfgang R Sperr
Journal: Blood (2013)
"Detection of K-ras Oncogene Mutations in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis"
Authors: None Mills
Journal: JNCI Journal of the National Cancer Institute (1995)

The Journal introduced an incorrect statement in the methods sections of the text and abstract of this paper without consulting the authors; our mistake inadvertently changed the “n” in the study. We fully recognize the egregiousness of this kind of error, because the printed version can never be corrected and the disservice to the authors can never by fully redressed. The Journal sincerely apologizes to Mills et al. and to Journal readers. Below is the correct version of the full abstract and the correct first sentence of the “Materials and Methods” section.
Cellular Changes in Cancer Following Isolation Perfusion Using Nitrogen Mustard
Authors: P D TOLINTINO, R L ALFONSO, S J JULIANO, C CRISOSTOMO, E FRANCISCO
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract IA02: Genomic organization of yeast chromatin and gene regulatory complexes
Authors: B. Franklin Pugh
Journal: Cancer Research (2016)

Abstract The large number of genes across eukaryotic genomes begs the question as to whether they are all fundamentally regulated in the same manner. Clearly, sequence-specific factors direct gene-specific regulation, but then do all downstream events proceed along a common path? To begin to address this question, we use ChIP-exo to map the precise contact points of proteins along genomic DNA. The near single-bp readout provides structural insights into how proteins are organized into complexes across genomes, and how they might position nucleosomes to regulate gene expression. Multiple classes of complexes occupy nucleosome-free promoter regions: an ensemble of sequence-specific factors and their coactivators, the core transcription machinery, chromatin remodelers and nucleosomes. This talk will focus on identifying common principles that determined how factors and chromatin organize themselves at promoters across co-regulated genes, and in genes in general. Citation Format: B. Franklin Pugh. Genomic organization of yeast chromatin and gene regulatory complexes. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr IA02.
SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7
Authors: Satoshi Narumi, Naoko Amano, Tomohiro Ishii, Noriyuki Katsumata, Koji Muroya, Masanori Adachi, Katsuaki Toyoshima, Yukichi Tanaka, Ryuji Fukuzawa, Kenichi Miyako, Saori Kinjo, Shouichi Ohga, Kenji Ihara, Hirosuke Inoue, Tadamune Kinjo, Toshiro Hara, Miyuki Kohno, Shiro Yamada, Hironaka Urano, Yosuke Kitagawa, Koji Tsugawa, Asumi Higa, Masakazu Miyawaki, Takahiro Okutani, Zenro Kizaki, Hiroyuki Hamada, Minako Kihara, Kentaro Shiga, Tetsuya Yamaguchi, Manabu Kenmochi, Hiroyuki Kitajima, Maki Fukami, Atsushi Shimizu, Jun Kudoh, Shinsuke Shibata, Hideyuki Okano, Noriko Miyake, Naomichi Matsumoto, Tomonobu Hasegawa
Journal: Nature Genetics (2016)
Surveillance of antimicrobial resistance in Bulgaria - a synopsis from BulSTAR 2003
Authors: M Petrov, N Hadjieva, T Kantardjiev, Tz Velinov, A Bachvarova
Journal: Eurosurveillance (2005)

We introduce Bulgarian Surveillance Tracking Antimicrobial Resistance (BulSTAR) and make the first report on surveillance data for 2003. This longitudinal surveillance programme monitors the isolation and antimicrobial susceptibility of all clinically significant microorganisms isolated from blood cultures, cerebrospinal fluid, upper and lower respiratory tract, urine and wound samples in the participating microbiology laboratories. Twenty eight public, 45 hospital and 6 private laboratories from all 28 counties of the Republic of Bulgaria participated in BulSTAR 2003. The total number of isolates from monitored sources during the surveillance period was 98 929. Seven microorganisms represented 72% of all isolated bacteria in BulSTAR 2003: Escherichia coli, Staphylococcus aureus, Proteus-Providencia-Morganella group, Klebsiella spp., Pseudomonas spp, Streptococcus pneumoniae and Streptococcus pyogenes. Generally the resistance of clinically significant Gram positive and Gram negative bacteria in Bulgaria was estimated to be at a medium level when compared with many other surveillance sources worldwide. A unique 32-year experiment on the population by treating all severe infections with an ampicillin/gentamicin combination resulted in twofold higher levels of resistance to amynoglycosides compared with other countries worldwide. This is due to the extremely conservative treatment schemes used in the former socialist countries, based on national directives and cheap domestic production of gentamicin and ampicillin. The forthcoming introduction of a computer network and improvements in detecting mistakes are expected to increase the sensitivity and the significance of BulSTAR surveillance system - an indispensable tool in the combat against increasing worldwide antibiotic resistance.
Abstract A12: Genomically unstable glioblastoma are sensitive to Parp inhibition
Authors: Kerrie L. McDonald, Mustafa Khasraw, Toni Rose Jue, Swapna Joshi, Julia Yin
Journal: Cancer Research (2015)

Abstract Background: The development of effective targeted drugs for the treatment of glioblastoma (GBM) represents a major unmet need. Veliparib (ABT-888; Abbvie) inhibits both PARP1 and PARP2 (poly[ADP-ribose] polymerase). The successful clinical application of veliparib and other PARP inhibitors (PARPi) will be assisted by the identification of predictive biomarkers. Materials and Methods: We performed whole genome sequencing (WGS) on ten GBM specimens with matched normal DNA. Mutations were detected using qSNP and GATK and indels called with Pindel and GATK. Somatic structural variants were identified using the qSV package. For all ten specimens we developed patient derived cell lines (PDCLs). We tested the efficacy of the combination of veliparib and temozolomide (TMZ) on all of the PDCLs. Results: Strikingly, in 2 patient samples denoted as G89 and G54, the mutation rate was at least 16-fold higher compared to the other 8 participants. G89 and G54 exhibited a large number of single nucleotide variants (SNVs), insertions, deletions and structural variant (SV) events (&amp;gt;2 million) when compared to the other 8 patient samples. The scale of genomic instability suggested defects in DNA maintenance, which could potentially define sensitivity to DNA damaging agents. Upon closer examination of the mutational profile of G89 and G54, mutations were found in at least one of the mismatch repair (MMR) genes: MLH1, MSH2, MSH6 and PMS2. We also detected mutations in other genes involved in DNA maintenance such as XRCC4, FANCA, FANCD2, ATR, RPA1, REV3L and PARP1. We designated these patients' GBM as U-GBM class. We found the U-GBM class of tumors, G89 and G54 to be hypersensitive to the combination of TMZ/veliparib. Conclusion: Mutations in DNA maintenance pathways may be a method for selecting patients for therapies involving the combination of DNA damaging agents such as radiotherapy, and PARP inhibitors. Additionally, the signature associated with genomically unstable GBM may be a method of identifying potential responders to PARP inhibitor therapy. Citation Format: Kerrie L. McDonald, Mustafa Khasraw, Toni Rose Jue, Swapna Joshi, Julia Yin. Genomically unstable glioblastoma are sensitive to Parp inhibition. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr A12.
Case 17-1982
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Kenneth A. Arndt, Terence J. Harrist
Journal: New England Journal of Medicine (1982)

Presentation of CaseA 77-year-old man was admitted to the hospital because of fever and subcutaneous masses.He was well until three months previously, when a dry cough developed. Two months before admission the temperature rose to 38.9°C, accompanied by chills, pleuritic pain, and anorexia. Erythromycin was administered for two weeks, without improvement. He was admitted to another hospital. X-ray films of the chest showed small bilateral pleural effusions. A tuberculin skin test was markedly positive. Repeated blood cultures and cultures of urine and pleural fluid yielded no microorganisms. Cytologic examination of the pleural fluid and microscopical examination of a . . .
Probable imported rather than autochthonous Plasmodium vivax cases in Italy
Authors: E Nicastri
Journal: Eurosurveillance (2012)

Preview this article: Probable imported rather than autochthonous Plasmodium vivax cases in Italy, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/17/50/art20338-en-1.gif
Ichthyosis Prematurity Syndrome
Authors: Su M. Lwin, Chao-Kai Hsu, James R. McMillan, Jemima E. Mellerio, John A. McGrath
Journal: JAMA Dermatology (2016)

Clarification of the differences between related chemical agents is key for maximum security efficiency during transportation.We advise physicians to educate their patients and reassure them that their moisturizer is not dangerous.Current procedures direct patients to alert TSA prior to their travel date and obtain approved labeling to minimize discomfort and stress.Alternatively, patients may arrange to have their ammonium lactate prescribed and ordered at a pharmacy in their destination city.
Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine
Authors: J Davidson, M N McLeod, H L White
Journal: American Journal of Psychiatry (1978)

The authors treated 19 depressive inpatients double-blind with a mean dose of 78 mg/day of phenelzine for 3 weeks to determine the possible relationship between monoamine oxidase (MAO) inhibition and the effectiveness of phenelzine. Clinical ratings made on the Hamilton Depression Rating Scale, the Beck Depression Inventory, and the SCL-90 indicated a minimum of 60% MAO inhibition had to be achieved for the drug to be consistently beneficial.
Physician sexual misconduct and patients' responses
Authors: A W Burgess
Journal: American Journal of Psychiatry (1981)

The author reports on 16 patient interviews involving a gynecologist who conducted internal examinations in a sexually abusive manner. The unusual features of the examination included length of time, misuse of the physician's hands, absence of a nurse, and excessive use of lubricant. The majority of patients did not stop the examination because they believed something was medically wrong, they trusted that the physician was conducting an ethical examination, or they felt powerless to interrupt him. Many of the patients developed an aversion to gynecological health care after the incident. The author suggests that mental health professionals who will treat the abused or the abuser identify areas for prevention of sexual exploitation and for early psychiatric intervention.
Reducing Emergency Department Visits for Acute Gastrointestinal Illnesses in North Carolina (USA) by Extending Community Water Service
Authors: Nicholas B. DeFelice, Jill E. Johnston, Jacqueline MacDonald Gibson
Journal: Environmental Health Perspectives (2016)

Previous analyses have suggested that unregulated private drinking water wells carry a higher risk of exposure to microbial contamination than regulated community water systems. In North Carolina, ~35% of the state's population relies on private wells, but the health impact associated with widespread reliance on such unregulated drinking water sources is unknown.We estimated the total number of emergency department visits for acute gastrointestinal illness (AGI) attributable to microbial contamination in private wells in North Carolina per year, the costs of those visits, and the potential health benefits of extending regulated water service to households currently relying on private wells for their drinking water.We developed a population intervention model using 2007-2013 data from all 122 North Carolina emergency departments along with microbial contamination data for all 2,120 community water systems and for 16,138 private well water samples collected since 2008.An estimated 29,400 (95% CI: 26,600, 32,200) emergency department visits per year for acute gastrointestinal illness were attributable to microbial contamination in drinking water, constituting approximately 7.3% (95% CI: 6.6, 7.9%) of all AGI-related visits. Of these attributable cases, 99% (29,200; 95% CI: 26,500, 31,900) were associated with private well contamination. The estimated statewide annual cost of emergency department visits attributable to microbiological contamination of drinking water is 40.2 million USD (95% CI: 2.58 million USD, 193 million USD), of which 39.9 million USD (95% CI: 2.56 million USD, 192 million USD) is estimated to arise from private well contamination. An estimated 2,920 (95% CI: 2,650, 3,190) annual emergency department visits could be prevented by extending community water service to 10% of the population currently relying on private wells.This research provides new evidence that extending regulated community water service to populations currently relying on private wells may decrease the population burden of acute gastrointestinal illness.DeFelice NB, Johnston JE, Gibson JM. 2016. Reducing emergency department visits for acute gastrointestinal illnesses in North Carolina (USA) by extending community water service. Environ Health Perspect 124:1583-1591; http://dx.doi.org/10.1289/EHP160.
Human Papillomavirus DNA versus Papanicolaou Screening Tests for Cervical Cancer
Authors: Alice Lytwyn, Laurie Elit, John W Sellors
Journal: New England Journal of Medicine (2008)

To the Editor: The outcome measures appear to have been chosen post hoc by Mayrand et al. (Oct. 18 issue)1 in their screening trial comparing human papillomavirus (HPV) testing with Papanicolaou (Pap) testing.1,2 The “conservative” outcome definition excludes biopsy-confirmed lesions identified at colposcopy but not verified on final excision or on biopsy immediately before ablation. Such lesions are included in the “liberal” definition, along with lesions identified by random biopsy and endocervical curettage. With the conservative definition, HPV testing is clearly superior, whereas with the liberal definition, neither strategy is clearly superior. Lesions included in the liberal definition may have no potential to progess, but it is unusual to extend this rationale to lesions seen at colposcopy. The authors suggest that these visible lesions may have been squamous metaplasia histologically misinterpreted as high-grade cervical intraepithelial neoplasia (grade 2 or higher), but this hypothesis was never confirmed by pathological re-review of the targeted biopsy specimens. We propose an alternative outcome measure: the presence of histologically verified, high-grade cervical intraepithelial neoplasia in either the colposcopically targeted biopsy specimen or the final excision specimen.
PHYSICIANS AND POLITICS.
Authors: W CARR
Journal: JAMA (1906)

It has long been regarded as a kind of unwritten law by physicians that they should take no part in politics. Perhaps, however, this is scarcely the correct way in which to describe the situation. Rather might it be said that physicians, as a body, have shown themselves apathetic in regard to politics, preferring to stand aloof from party strife and to look on the whole question as one in which they had slight concern. This attitude of indifference has been rudely shaken of late years, and the fact is being borne in gradually on medical men that, in order to protect their own interests and the interests of the general public, they must abandon this lethargic position and act both aggressively and defensively. There are many reasons why the physician should not eschew politics; indeed, there are more reasons in favor of the physician playing his part in the
Transduction of human melanoma cell lines with the human interleukin-7 gene using retroviral-mediated gene transfer: comparison of immunologic properties with interleukin-2
Authors: AR Miller, WH McBride, SM Dubinett, GJ Dougherty, JD Thacker, H Shau, DB Kohn, RC Moen, MJ Walker, R Chiu
Journal: Blood (1993)