tbuckley/cabot-search huggingface dataset:
A2.16 Association of 20 interferon related gene expression with response to infliximab treatment in ankylosing spondylitis: Pilot data
Authors: S Harrison, AN Burska, P Emery, H Marzo-Ortega, F Ponchel
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and Objectives</h3> Ankylosing spondylitis (AS) is a debilitating chronic inflammatory condition characterised by sacroiliac/axial joint inflammation and peripheral/extra-articular manifestations in some cases. Anti-TNF treatment has revolutionised disease control, however, not all patients respond, creating a significant need for biomarkers to tailor biological treatments to appropriate patients. Interferon (IFN)-related genes (IRGs) and gene expression signatures have been associated with a number of inflammatory autoimmune arthritides, including AS. Therefore, the aims of this study were to explore a large panel of IRGs to select possible candidate for further work developing a signature. <h3>Materials and Methods</h3> 12 AS patients treated with infliximab (4 infusions of 6 mg/kg over 22 weeks) were selected from our tissue bank. Response was defined as a decrease in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) of &gt; 2 points or &gt; 50% at 6 months post treatment. cDNA was obtained from baseline peripheral blood mononuclear cells and was analysed for the expression of 75 IRGs using custom TaqMan Microfluidics Cards. Differences in gene expression between response groups was then evaluated using Mann-Whitney U tests, box- plots and unsupervised hierarchical clustering. <h3>Results</h3> Overall 6 patients responded to treatment (R) and 6 did not (NR). Although the study was exploratory and not powered for statistical significance, between the two groups, a trend (P &lt; 0.200) was observed for 12 IRGs (up/down regulated in R), with clear difference in levels of expression seen on box-plots. A number of these have been implicated in the pathogenesis of RA and SLE, as well as response to infliximab in RA, however 6 were unique to AS. Cluster analysis highlighted 20 genes driving the differences between patients. R and NR were relatively well segregated by this analysis with 5/7 responder in a group and 1/5 in the second. <h3>Conclusions</h3> In this pilot study, we demonstrate the potential for IRGs to be associated with response to anti-TNF treatment in AS. Furthermore, certain genes may be unique to AS differentiating it from other autoimmune inflammatory diseases. However, due to small sample numbers, statistical significance could not be reliably determined. Selected genes will now be validated in a larger cohort to determine reproducibility and statistical significance.
Pose de bouton d'emblée au cours de la gastrostomie percutanée endoscopique chez l'enfant
Authors: D Druelle, A Robert-Dehault, S Coopman, D Guimber, D Turck, F Gottrand, L Michaud
Journal: Endoscopy (2011)

Introduction: La mise en place d'une sonde de gastrostomie percutanée endoscopique par la technique „pull„ (S-GPE) sous anesthésie générale (AG) est la méthode de référence pour l'accès entéral à long terme. Un bouton de gastrostomie est souvent posé dans un second temps, nécessitant une nouvelle AG. Le but de ce travail était d'évaluer la mise en place d'un bouton de gastrostomie d'emblée par technique „push„ sous contrôle endoscopique (B-GPE) chez l'enfant en termes de faisabilité et de sûreté. Les complications et le coût de la B-GPE ont été comparés à ceux de la S-GPE.
P2-15-05: Excision of the Primary Tumour in Patients with Metastatic Breast Cancer – Will E2108 Provide the Definitive Answer?
Authors: S Samiee, P Berardi, N Bouganim, L Vandermeer, A Arnaout, D Mirsky, S Dent, J-M Caudrelier, M Chasen, M Clemons
Journal: Cancer Research (2011)

Abstract Background: Approximately 10% of new breast cancer patients will present with overt synchronous metastatic disease. Controversy exists about the optimal local management of these patients. While several series suggest that removal of primary tumour is associated with a survival benefit, the retrospective nature of these studies raises considerable methodological challenges. We decided to evaluate the experience at our centre around the impact of surgery in patients with synchronous metastasis. Method: Case records of all patients seen with primary breast cancer and concurrent distant metastases between 2005 to 2007 were reviewed. Demographic and treatment data was collected. The study endpoints compared both overall survival and symptomatic local progression rates between patients who had breast surgery and those who did not. RESULTS: 111 patients were identified. Median follow-up 40 months (0.6-71 months). Patients were divided into two groups: those patients who underwent breast surgery (n=48; 29/48 had surgery immediate prior to metastatic diagnosis) and those that did not have surgery(n = 63). The surgical group were less likely to present with T4 tumours (20% vs 36%), N3 nodal disease (8% vs 19%) and visceral metastasis (67% vs 73%)when compared with non-surgical group. Improved overall survival (49 months vs 33 months; p=0.01) and less symptomatic local progression rates ( 15% vs 43%, p &amp;lt; 0.001 ) were seen in the surgical group compared to the non-surgical group. CONCLUSIONS: The optimal local management of patients with metastatic breast cancer is unknown. Despite the surgery group demonstrating an improved overall survival and symptomatic local control, this group had less aggressive disease at presentation. These results confirm the need for prospective randomized studies. E2108, an ongoing Phase III Trial, was designed to assess the effect of breast surgery in metastatic patients responding to first line systemic therapy. If excision of the primary tumour is associated with a survival benefit, then the pre-selected subgroup of patients that have responded to initial systemic therapy is the desired population to put this hypothesis to test. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P2-15-05.
Osteogenic Differentiation: Periodic Nanoneedle and Buffer Zones Constructed on a Titanium Surface Promote Osteogenic Differentiation and Bone Calcification In Vivo (Adv. Healthcare Mater. 3/2016)
Authors: Peng Yu, Xiaojing Zhu, Xiaolan Wang, Shuangying Wang, Weiping Li, Guoxin Tan, Yu Zhang, Chengyun Ning
Journal: Advanced Healthcare Materials (2016)

On page 364, C. Ning and co-workers present the effects of constructing functionalized microscale zones on titanium bone implants on osteogenesis. Periodic microscale nanoneedle zones and buffer zones on titanium implants surface promote osteoblast proliferation, modulate zonal protein adsorption and apatite deposition capacities, as well as induce mechanotransduction, leading to effective bone regeneration.
Human and entomological surveillance of Toscana virus in the Emilia-Romagna region, Italy, 2010 to 2012
Authors: M Calzolari, P Angelini, A C Finarelli, R Cagarelli, R Bellini, A Albieri, P Bonilauri, F Cavrini, M Tamba, M Dottori, P Gaibani, S Natalini, G Maioli, M Pinna, A Mattivi, V Sambri, A Pierro, M P Landini, G Rossini, G Squintani, S Cinotti, S Varani, C Vocale, E Bedeschi
Journal: Eurosurveillance (2014)

Toscana virus (TOSV), transmitted by phlebotomine sandflies, is recognised as one of the most important causes of viral meningitis in summer in Mediterranean countries. A surveillance plan based on both human and entomological surveys was started in 2010 in the Emilia-Romagna region, Italy. Clinical samples from patients with neurological manifestations were collected during 2010 to 2012. The surveillance protocol was improved during these years, allowing the detection of 65 human infections. Most of these infections were recorded in hilly areas, where sandflies reach the highest density. Entomological sampling around the homes of the patients resulted in a low number of captured sandflies, while later sampling in a hilly area with high number of human cases (n=21) resulted in a larger number of captured sandflies. Using this approach, 25,653 sandflies were sampled, of which there were 21,157 females, which were sorted into 287 pools. TOSV RNA was detected by real-time PCR in 33 of the pools. The results highlighted the role of Phlebotomus perfiliewi as the main vector of TOSV and a potential link between vector density and virus circulation. This integrated system shows that an interdisciplinary approach improves the sensitiveness and effectiveness of health surveillance.
Metronidazole-Resistant Vaginal Trichomoniasis — An Emerging Problem
Authors: Jack D. Sobel, Vijayalakshmi Nagappan, Paul Nyirjesy
Journal: New England Journal of Medicine (1999)

To the Editor: Trichomonal resistance to metronidazole was reported soon after its introduction and has been reported in many areas in the world. Although a sexually transmitted disease with dire consequences related to human immunodeficiency virus transmission, trichomoniasis is not a reportable infection, and epidemiologic data on its incidence in the United States are not available. Therefore, it is not surprising that accurate figures on metronidazole-resistant trichomoniasis are almost nonexistent. Nevertheless, clinically important resistance is considered rare, with estimates of high-level resistance to metronidazole occurring in only 1 in 2000 to 3000 cases.1 In clinics specializing in chronic vaginitis that . . .
Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease
Authors: Eva M. Lonn, Jackie Bosch, Patricio López-Jaramillo, Jun Zhu, Lisheng Liu, Prem Pais, Rafael Diaz, Denis Xavier, Karen Sliwa, Antonio Dans, Alvaro Avezum, Leopoldo S. Piegas, Katalin Keltai, Matyas Keltai, Irina Chazova, Ron J.G. Peters, Claes Held, Khalid Yusoff, Basil S. Lewis, Petr Jansky, Alexander Parkhomenko, Kamlesh Khunti, William D. Toff, Christopher M. Reid, John Varigos, Lawrence A. Leiter, Dora I. Molina, Robert McKelvie, Janice Pogue, Joanne Wilkinson, Hyejung Jung, Gilles Dagenais, Salim Yusuf
Journal: New England Journal of Medicine (2016)

Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its role in persons at intermediate risk and with lower blood pressure is unclear.In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years.The mean blood pressure of the participants at baseline was 138.1/81.9 mm Hg; the decrease in blood pressure was 6.0/3.0 mm Hg greater in the active-treatment group than in the placebo group. The first coprimary outcome occurred in 260 participants (4.1%) in the active-treatment group and in 279 (4.4%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.79 to 1.10; P=0.40); the second coprimary outcome occurred in 312 participants (4.9%) and 328 participants (5.2%), respectively (hazard ratio, 0.95; 95% CI, 0.81 to 1.11; P=0.51). In one of the three prespecified hypothesis-based subgroups, participants in the subgroup for the upper third of systolic blood pressure (>143.5 mm Hg) who were in the active-treatment group had significantly lower rates of the first and second coprimary outcomes than those in the placebo group; effects were neutral in the middle and lower thirds (P=0.02 and P=0.009, respectively, for trend in the two outcomes).Therapy with candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day was not associated with a lower rate of major cardiovascular events than placebo among persons at intermediate risk who did not have cardiovascular disease. (Funded by the Canadian Institutes of Health Research and AstraZeneca; ClinicalTrials.gov number, NCT00468923.).
An Unusual Right Ventricle Metastasis From Mandible Squamous Cell Carcinoma Detected On FDG PET/CT
Authors: Yang Lu
Journal: Clinical Nuclear Medicine (2015)

A patient with history of mandible squamous cell carcinoma underwent an FDG PET/CT scan. A focal hypermetabolic right ventricle lesion was noted and suggestive of metastasis. A cardiac MRI verified the right ventricle wall mass. Further endomyocardial biopsy confirmed the diagnosis of metastatic squamous cell carcinoma.
AB0527 Hla-b27 analysis by flow citometry in brazilian patients with ankylosing spondylitis and psoriatic arthritis
Authors: C. Goldenstein-Schainberg, S. Carrasco, C. Saad, C. Goncalves, P. Sampaio-Barros, E. Parra
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) share common characteristics including the association with HLA-B27 antigen, which is positive in &gt; 80% and 20-60% patients respectively and mostly related to axial involvement. Considerable geographical HLA-B27 prevalence in general population varies from &gt; 50% in Canadian Indians and virtually 0% in Africans. HLAB27 may be detected by a variety of methods with similar sensibility and specificity, but different cost including serological (luminex system, solid phase assay), ADCC, molecular biology (PCR) and flow cytometry. <h3>Objectives</h3> To establish the prevalence of HLA-B27 in Brazilian patients with AS and PsA from a single university center using a low cost flow cytometry test. <h3>Methods</h3> AS and PsA patients followed at theEpA clinic from the Rheumatology Division of the Hospital das Clinicas, University of São Paulo were evaluated. HLA-B27 was analyzed in peripheral blood lymphocytes by flow cytometry using the FacsCalibur Becton/Dinkinson (BD). Fifty µl of heparinizedwhole blood from all patients and controls were incubated with 30µl HLA-B27/CD3 antibody (BD) for 30 minutes in the dark followed by red cell lysis with 2ml of lysis solution (BD). All samples were washed twice with PBS and fixed with 250µl of 1% paraformaldehyde. Statistical analysis was performed using Fisher's test and P&lt;0.005 was considered significant. <h3>Results</h3> A total of 182 patients (88 AS, 94 PsA) and 72 controls were studied. Axial involvement occurred in 97% AS and 50% PsA patients, whereas 63% AS and 89% PsA had peripheral disease. HLA-B27 was positive in 83% (73/88) AS, 33% (31/94) PsA and 2.7% (2/72) controls. In AS, HLA-B27+ was associated with axial but not peripheral involvement (96%,70/73 vs61%,45/73, <i>p</i>= 0.047). Conversely, HLA-B27 was positive in 90% (28/31) peripheral PsA vs. 55% (17/31) axial PsA patients (<i>p</i>=0.003) <h3>Conclusions</h3> The detection of HLA-B27 by flow cytometry in Brazilian patients with AS and PsA was similar to worldwide reported prevalences proving to be a reliable inexpensive method. In AS, HLA-B27 association with axial manifestation was confirmed but in PSA, link with peripheral disease may suggest different patterns of site injury indicating that HLA-B27 testing is of little clinical value in predicting the presence of axial PsA. <h3>Disclosure of Interest</h3> None Declared
P77 Lung clearance index (LCI) in children with severe, therapy resistant asthma (STRA)
Authors: S. Irving, A. Bush, C. Bossley, A. Gupta, S. Saglani
Journal: Thorax (2011)

<h3>Introduction</h3> Spirometry is often normal in children with STRA, and is thus a poor outcome measure (1). Lung Clearance Index is a sensitive, non-effort dependent measure of distal airway gas mixing, which has been shown to be more sensitive than spirometry in Cystic Fibrosis (2). We hypothesised that LCI would be a better marker of steroid response in STRA than spirometry. <h3>Patients and Methods</h3> 22 STRA children (Mean age 11.9 years, 15 male) had LCI and spirometry measured before and 4 weeks after intramuscular triamcinolone. <h3>Results</h3> LCI was elevated in 18/22 prior to triamcinolone and 12/22 at the follow-up; in contrast FEV<sub>1</sub> was only abnormal in 10/22 and 6/22 pretriamcinolone and posttriamcinolone respectively. Mean LCI fell from 7.86 to 7.25 (p&lt;0.05) but there was no statistically significant decrease in FEV<sub>1</sub> after triamcinolone. <h3>Conclusion</h3> LCI is a better discriminant of STRA then FEV<sub>1</sub>, and is more responsive to steroid treatment. LCI may thus be a better outcome measure in STRA.
An Unusual Case of Unilateral Lactation and a Vanishing Limb
Authors: ROBERT MANSBERG, JOHN M. ROBERTS, JOHN R. TURTLE
Journal: Clinical Nuclear Medicine (2000)

I-123 scintigraphy showed unilateral lactation and tetrofosmin scintigraphy showed the virtual disappearance of the right lower limb in a 43-year-old woman who had had polio.
Low rate of progressive disease in metastatic gastric cancer using tandem chemotherapy with four active compounds
Authors: B. J. Wormann, A. Pies, P. Petersen
Journal: Journal of Clinical Oncology (2006)

14069 Background: Taxanes and irinotecan have significantly increased the therapeutic options in the treatment of metastatic gastric cancer. However, the potential of all active substances is highest in first - line treatment. The rate of second remissions is low and survival after relapse is short. We performed a phase II study incorporating 5FU, irinotecan, cisplatin and docetaxel in a tandem protocol for first line treatment of patients with metastastic adenocarcinoma of stomach or cardia. Methods: Chemonaive patients received a 30-minute infusion of irinotecan 80 mg/m 2 followed by IV bolus leucovorin 20 mg/m 2 and infusional 5FU 2000 mg/m 2 over 24 hours on days 1, 8 and 15. The second block included docetaxel 25 mg/m 2 over 60 minutes followed by a 30-minute infusion of cisplatin 40 mg/m 2 on days 29, 36 and 43. Patients were scheduled to receive two complete cycles. Primary objective was evaluation of remission rate. Further objectives were toxicity and overall survival. Results: 32 patients were included, 25 patients are currently evaluable. The median age was 56 years (36 - 72), 10 female and 15 male patients. 10/25 (40%) patients achieved a partial remission, 3 of these 10 patients had a very good partial remission. 13 (52%) patients had stable disease, and 2 (8%) patients progressed early. Main toxicities grade ≥ 3 were diarrhea (8/50 cycles), nausea and vomiting (3/50), neutropenia (2/50), anemia (1/50) and renal insufficiency (1/50). The median survival time was 11.7 months. Conclusions: This treatment schedule includes the four most active substances in the treatment of metastastic gastric cancer in a tandem protocol. Only 2/25 patients had progressive disease under therapy. Toxicity was moderate. Dose intensication may further increase the remission rate. No significant financial relationships to disclose.
SP0099 Ultrasound in Trauma - What the Rheumatologist Needs to Know
Authors: S. Bianchi
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Posttraumatic pain of the ankle and foot can result from either acute trauma or disorders related to chronic microtrauma. The latter are common causes of referral in everyday rheumatologic clinical practice. Rheumatologists must be familiar with the clinical and imaging appearance of these conditions since they can mimic other joint or periarticular disorders and need specific treatment. Musculoskeletal ultrasound (US) is nowadays considered, together with standard radiographs, the first line imaging techniques in ankle and foot disorders. US is non-invasive, dynamic, cheap and patient-friendly. When performed by an experienced sonologist, using an up-to-date equipment, it allows an accurate assessment of joints, tendons, nerves and bone surfaces. The aim of this lecture is to provide a pictorial review of the most common disorders of the ankle and foot related to chronic microtrauma. We will present the MSUS technique of examination followed by paradigmatic sonograms and clips of micro traumatic diseases affecting tendons (Tibialis posterior and anterior), synovial bursae (Bursitis), ligaments (Plantar plate tears, Spring ligament), nerves (Morton neuroma), bones (Stress fractures), veins (Plantar vein thrombosis). For each condition we will discuss the role of US in the diagnostic work-up and in guiding therapeutic and/or diagnostic procedures. US coupled to clinical evaluation and standard radiographs allows detection and careful assessment of most disorders of the ankle and foot related to chronic microtrauma. In selected patient US allows a real-time, accurate guidance of local procedures. <h3>Disclosure of Interest</h3> None Declared
The Risk of<i>Pneumocystis carinii</i>Pneumonia among Men Infected with Human Immunodeficiency Virus Type 1
Authors: John Phair, Alvaro Muñoz, Roger Detels, Richard Kaslow, Charles Rinaldo, Alfred Saah
Journal: New England Journal of Medicine (1990)

We assessed the risk of pneumonia due to Pneumocystis carinii in 1665 participants in the Multicenter AIDS Cohort Study who were seropositive for human immunodeficiency virus type 1 (HIV-1) but did not have the acquired immunodeficiency syndrome (AIDS) and were not receiving prophylaxis against P. carinii. During 48 months of follow-up, 168 participants (10.1 percent) had a first episode of P. carinii pneumonia.
The Cardiovascular Effects of Cervicothoracic Vagectomy in the Human Being
Authors: Robert S. Fraser, Carleton B. Chapman
Journal: New England Journal of Medicine (1953)

IN the normal human being, vagal impulses are thought to affect the heart in the following ways: by decreasing the rate of production of impulses by the sinoatrial node, by prolonging the atrioventricular conduction time and by diminishing the force of atrial and ventricular contraction.In the first instance, slowing of impulse production by the sinoatrial node is ultimately due to afferent stimuli from the aortic arch, the carotid sinus and the great veins of the atria. Numerous other sites have been thought to initiate afferent impulses that cause cardiac slowing. These afferent stimuli, from whatever source, converge on the . . .