tbuckley/cabot-search huggingface dataset:
S92 Non-malignant pleural effusions (NMPE): aprospective study into 355 consecutive unselected patients
Authors: S Walker, A Morley, L Stadon, D De Fonseka, A Medford, N Maskell
Journal: Thorax (2016)

<h3>Introduction and objectives</h3> Non-Malignant Pleural Effusions (NMPE) have an estimated annual incidence of 200,000 in the UK.<sup>1</sup> They are often secondary to underlying organ dysfunction, with congestive heart failure (CHF) the leading cause. CHF itself carries a high mortality risk, with 28% of patients with New York Heart Association(NYHA) class IV dying within a year.<sup>2</sup> Despite this, information on baseline characteristics, prognostic features and mortality in NMPE is sparse. Our aim is to determine the mortality rates in NMPEs in a prospective observational trial. <h3>Methods</h3> We recruited 784 consecutive patients presenting to a pleural service, between 03/2008 and 03/2015, with an undiagnosed pleural effusion. Further analysis was conducted on the 355 patients with NMPE. Pleural biochemistry, cytology, thoracic USS and chest radiograph were performed. Echocardiogram, CT scans, radiological-guided biopsy and medical thoracoscopy were undertaken as clinically indicated. Patients were followed-up for a minimum duration of 12 months with final diagnosis decided by independent review by 2 respiratory consultants. Survival data was calculated from study entry to death. Surviving patients were censored on 07/2016. <h3>Results</h3> Of the 784 patients, 355 (45%) were diagnosed with a NMPE. These patients had a mean age of 68 (SD17) with 69% of patients male. Patients with CHF (HR 4.7 CI: 2.3–9.5) had a 50% 1-year mortality and a mean age of 79. Renal failure (HR 5.2 CI: 2.1–12.9) and liver failure (HR 4.8 CI: 1.9–11.8) patients had 1-year mortality rates of 31% and 25% respectively (HR c/w inflammatory pleuritis). Bilateral effusions (HR 2.6 CI 1.7–3.9) and transudative effusions (HR 3.1 CI: 2.2–4.3) were associated with a worse prognosis in patients with NMPE, with a 57% and 44% 1-year mortality respectively. <h3>Conclusion</h3> This is the largest prospectively collected series in patients with NMPE, demonstrating that those secondary to organ dysfunction have an extremely high 1-year mortality. The presence of a pleural effusion in patients with CHF is a marker of severe disease, almost doubling the mortality risk compared to patients with NYHA class IV CHF. <h3>References</h3> Light RW. Pleural effusions. <i>Medical Clinics of North America</i> 2011;<b>95</b>(6): 1055–70. Muntwyler J. One-year mortality among unselected outpatients with heart failure. <i>EHJ</i> 2002;<b>23</b>(23):1861–6.
Outocomes of Second Unrelated Cord Blood Transplant for Relapse After First Allogeneic Transplant In Adult Patients with Progressive Acute Myeloid Leukimia/Myelodysplastic Syndrome.
Authors: Sachi Tainosho, Kazuhiro Masuoka, Aya Nishida, Nobuaki Nakano, Kazuya Ishiwata, Masanori Tsuji, Hisashi Yamamoto, Yuki Asano-Mori, Naoyuki Uchida, Koji Izutsu, Atsushi Wake, Shigeyoshi Makino, Akiko Yoneyama, Shuichi Taniguchi
Journal: Blood (2010)
2-Methoxyestradiol enhances TRAIL mediated apoptosis in ovarian cancer cells but not in normal cells in both a caspase-dependent and independent manner
Authors: Mauricio Cuello, Sumie Kato, Anil Sadarangani, Jorge Branes, David Mayerson, Claudia Saez, Roger Gejman, Gareth Owen, Stanley Lipkowitz
Journal: Cancer Research (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

1920 

Ovarian cancer constitutes the main cause of death from gynecologic cancers. Despite using extensive cytoreductive surgery followed by intensive chemotherapy there is poor survival at advanced stages. Thus, finding new strategies of treatment constitutes a great challenge. We already demonstrated that TRAIL, a member of TNF family, induces apoptosis in ovarian cancer cells. In addition, we have found that 2-methoxyestradiol (2ME), an estrogen metabolite, kills cancer but not normal ovarian cells. Objectives: We investigated if TRAIL induces apoptosis in primary cultured ovarian cancer cells and if 2ME enhances TRAIL mediated apoptosis in this type of cancer. Furthermore, we investigated the mechanisms behind any interaction between them. Methods: Cell viability was studied by the MTS assay. Apoptosis was confirmed through DNA laddering, FACS, in vitro caspase activity assay, and W-B of different proteins involved in the apoptotic cascade. Results: TRAIL induces cell death in primary cultured ovarian cancer cell lines (established from advanced epithelial carcinomas) but not in normal cells. More interesting TRAIL did not affected cell cultures established from benign ovarian tumors or low malignant potential ovarian cancers. 2ME also induces cell death in primary cultures of advanced ovarian cancers but not in benign ovarian tumors or normal ovary. Pretreatment with 2ME enhances TRAIL mediated apoptosis in advanced ovarian carcinomas with no effect on low malignant potential tumors or benign tumors or normal ovary. The interaction was synergistic by fractional inhibition analysis. The mechanism behind this interaction involved increase in TRAIL-R2 (RT-PCR, W-B), increase in BID cleavage, increase in BCL2 phosphorylation, increase in caspase-8, -9, and -3 activity, and increase in cytochrome-c release. Interestingly, the use of a non-selective caspase inhibitor (ZVAD-fmk) or selective caspase inhibitors (caspase-8, -9 inhibitors) only partially reverted the effect. The incomplete reversion was explained by increased release of AIF from mitochondria suggesting triggering of a caspase independent apoptosis cascade. The stable overexpression of BClxL in these cancer cells resulted in almost complete reversion of the synergistic effect observed with the combination of 2ME + TRAIL. Conclusions: These data suggest 2ME enhances TRAIL mediated apoptosis by increasing both extrinsic and intrinsic apoptotic cascades. The apoptotic effect is due to activation of both caspase dependent and independent cascades. TRAIL and 2ME, might be considered in the treatment of advanced ovarian carcinoma. (FONDECYT 1050744)
Implantable Device Reverses Leg Paralysis in Monkeys
Authors: Tracy Hampton
Journal: JAMA (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Two Novel WT-1 Derived Peptides Induce CD4+ peptide–specific T Cell Proliferation in Patients with Myelodysplastic Syndrome (MDS)
Authors: Monica Bocchia, Micaela Ippoliti, Marzia Defina, Rosaria Crupi, Maristella Tassi, Michela Rondoni, Alessandro Gozzetti, Francesco Lauria
Journal: Blood (2008)
A third of acute care trusts raised alerts over serious problems last month
Authors: Adrian O’Dowd
Journal: BMJ (2017)

Around a third of acute care NHS trusts in England raised alerts last month that they were either close to being unable to deliver comprehensive care or had high potential of putting patient care and safety at risk because of winter pressures.

The revelations came on 6 January in a blog published by the health think tank the Nuffield Trust,1 which has been analysing performance data issued by NHS England.2 The data include details recorded under a new system called the operational pressures escalation level (OPEL) framework.3

The new system, which replaced the “red” and “black” alerts system, allows more analysis of the operational pressures facing NHS hospitals in winter. Trusts are required to record which of four different …
P3.02c-014 Patients with Recurrence after Resection of Lung Cancer Are Good Candidates for the beyond over Progressive Disease Application of Bevacizumab
Authors: Tatsuya Yoshimasu, Mitsumasa Kawago, Yoshimitsu Hirai, Shoji Oura, Yozo Kokawa, Miwako Miyasaka, Mariko Honda, Yuka Aoishi, Aya Oku, Yoshiharu Nishimura
Journal: Journal of Thoracic Oncology (2017)
P3.01-035 Nicotine Enhances Hepatocyte Growth Factor-Mediated Lung Cancer Cell Migration
Authors: Remi Yoneyama, Kazutetsu Aoshiba, Kinya Furukawa, Makoto Saito, Hiroaki Kataba, Hiroyuki Nakamura, Norihiko Ikeda
Journal: Journal of Thoracic Oncology (2017)
P3.02b-048 Oral Vinorelbine Monotherapy in Patients with EGFR+ NSCLC after Failure of EGFR-TKI in First Line: A Prospective Study
Authors: Dariusz Kowalski, Giuseppe Luigi Banna, Rodryg Ramlau, Giovanni Ceresoli, Andrea Camerini, Janusz Milanowski, Michele Caruso, Philippe Landreau, Jean-Claude Vedovato, Eng Huat Tan
Journal: Journal of Thoracic Oncology (2017)
PUB019 Preoperative Needle Biopsy and Tumor Spread through Alveolar Spaces (STAS) in Resected Lung Adenocarcinomas
Authors: Koji Kameda, Takashi Eguchi, Shaohua Lu, Stephen Solomon, Matthew Bott, David Jones, Natasha Rekhtman, William Travis, Prasad Adusumilli
Journal: Journal of Thoracic Oncology (2017)
P265 Concurrent statin and macrolide use during pneumonia treatment improves survival to hospital discharge and beyond
Authors: FS Grudzinska, R Dancer, D Thickett
Journal: Thorax (2016)

<h3>Background</h3> Pneumonia is a leading cause of hospital admission. With mortality exceeding 18% (BTS CAP Audit 2013) the search for strategies to reduce this continues. Statins are receiving increasing attention for a potential role in improving survival from acute bacterial infections. MHRA guidance recommends that statins should be paused during treatment with a macrolide due to risk of myopathy and rhabdomyolysis. We undertook a retrospective study to determine the frequency of concurrent statin and macrolide administration in patients diagnosed with pneumonia and whether concurrent use of a statin and macrolide antibiotic to treat pneumonia improved survival compared to stopping statin treatment, and whether concurrent use was safe and tolerable. 165 patient episodes were identified by searching for patients who were coded as having pneumonia and were prescribed a statin and macrolide. Data was collected on statin, dose, severity of pneumonia including intensive care admission, comorbidities, survival, renal and liver function. <h3>Results</h3> 62% of the cohort continued a statin throughout pneumonia treatment. In the continued statin group survival to hospital discharge was 79% versus 64% in the group in whom the statin was paused (p = 0.034). Severity of pneumonia (CURB score) was similar for both groups. Statin users were less likely to be admitted to intensive care (28% vs 46%, p = 0.0219). Charlson comorbidity index score was similar for the statin (6.4, IQR = 5–8) and non-statin (6.1, IQR = 5–8) groups. There was no increased risk of acute liver, kidney injury or myopathy in the continued statin group. <h3>Conclusion</h3> Continued statin use during treatment for pneumonia with a macrolide antibiotic is safe and may improve survival compared to stopping statin use. Current guidance on concurrent use of statins and macrolides should be reviewed.
High Incidence of Bcl-2/IgH Rearrangement in Mexican Patients With Follicular Lymphoma and Its Relevance as a Marker for Minimal Residual Disease.
Authors: Rosa M. Arana, Pedro Sobrevilla-Calvo, Silvia Rivas-Vera, Enrique Baez, Severiano Baltazar, Jorge Duque, Ignacio Gregorio, Francisco Tripp, Oscar Garces, Luis Aguilar, Luis Flores
Journal: Blood (2005)
P2.02-050 Gender and Smoking Influence on Non-Small Cell Lung Cancer Histology and Tnm Stage in a Brazilian Population
Authors: Ricardo Terra, Letícia Lauricella, Priscila Da Costa, Henrique Nietmann, Federico Cipriano, Fernando Abrão, Daniele Cataneo, Filippe Gouvêa
Journal: Journal of Thoracic Oncology (2017)
Preliminary Activity of Nilotinib (AMN107), a Novel Selective Potent Oral Bcr-Abl Tyrosine Kinase Inhibitor, in Newly Diagnosed Philadelphia Chromosome (Ph)-Positive Chronic Phase Chronic Myelogenous Leukemia (CML-CP).
Authors: Elias Jabbour, Jorge Cortes, Francis Giles, Susan O’Brien, Laurie Letvak, Hagop Kantarjian
Journal: Blood (2006)
MA06.10 A Pooled Analysis Comparing the Outcomes of Elderly to Younger Patients on NCTN Trials of Concurrent CCRT for Stage 3 NSCLC
Authors: Thomas Stinchcombe, Ying Zhang, Everett Vokes, Joan Schiller, Jeffrey Bradley, Karen Kelly, Walter Curran, Steven Schild, Benjamin Movsas, Gerald Clamon, Ramaswamy Govindan, George Blumenschein, Mark Socinski, Neal Ready, Wallace Akerley, Harvey Cohen, Herbert Pang, Xiaofei Wang
Journal: Journal of Thoracic Oncology (2017)
Corrigendum to “Signal transducer and activator of transcription 3 is a major kinase-independent target of sorafenib in hepatocellular carcinoma”
Authors: Wei-Tien Tai, Ann-Lii Cheng, Chung-Wai Shiau, Hsiang-Po Huang, Jui-Wen Huang, Pei-Jer Chen, Kuen-Feng Chen
Journal: Journal of Hepatology (2017)
P2.03a-025 Randomized, Double-Blind, Phase 3 Study Comparing Biosimilar Candidate ABP 215 with Bevacizumab in Patients with Non-Squamous NSCLC
Authors: Nick Thatcher, Michael Thomas, Gyula Ostoros, Jean Pan, Jerome Goldschmidt, Michael Schenker, Vladimir Hanes
Journal: Journal of Thoracic Oncology (2017)
Coronary Ostial Endarterectomy in Takayasu's Aortitis. Confirmation of Patency Nine Years Postsurgically.
Authors: Takashi Fujiwara, Hisao Masaki, Hisayoshi Yamane, Hiroshi Yoshida, Tatsuki Katsumura
Journal: Circulation (1992)

A case of Takayasu's aortitis with severe bilateral coronary ostial stenosis is reported. A transaortic coronary endarterectomy was performed and sufficient patency was confirmed angiographically 9 years after the operation. This is the first report of late coronary angiography after a transaortic coronary ostial endarterectomy in Takayasu's aortitis. The efficacy of this procedure for coronary ostial stenosis in Takayasu's aortitis is emphasized.
NCOG-13. THE IMPACT OF NEURO-ONCOLOGY PATIENTS’ NEUROPSYCHOLOGICAL FUNCTION ON FAMILY CAREGIVERS’ EMOTIONAL HEALTH
Authors: Xinxuan Cao, Jason Weimer, Heidi Donovan, Terri Armstrong, Dianxu Ren, Paula Sherwood
Journal: Neuro-Oncology (2016)

It has been shown that family caregivers of persons with a primary malignant brain tumor (PMBT) report high levels of depressive symptoms and burden and that caregivers’ emotional health is closely linked to the patient’s overall neuropsychological status. However, it is not clear which domains of neuropsychological function place caregivers at highest risk for poor emotional health, which severely limits interventions to improve caregiver health. As part of an ongoing NINR longitudinal trial (R01NR013170), 113 dyads of persons newly (within two months) diagnosed with a PMBT and >21 years old were recruited from two NCI designated cancer centers. Patients’ neuropsychological status was measured using a comprehensive test battery with excellent psychometric properties during in-person interviews by trained research assistants. Caregivers completed the Center for Epidemiologic Studies Depression-Scale and Caregiver Reaction Assessment (CRA) Scale (burden). Descriptive and correlational analyses were performed using SPSS version 23. Delayed recall of the Auditory Verbal Learning Test (r=-.36), Rey-Osterrieth Figure Test immediate recall (r=-.46) and delayed recall (r=-.51), Logical Memory subtest (r=-.33), and Digit Symbol Test (r=-.33) were significantly correlated with caregiver burden at p<.01. Letter Number Sequencing (r=-.31) and Rey-Osterrieth Figure Test (Copy) (r=-.28) were also significantly associated with caregiver burden (p<.05). Rey Figure Immediate Recall (r=-.26) and Digit Symbol Coding (r=-.30) were significantly associated with caregivers’ depressive symptoms (p<.05). Results suggest that verbal learning and general memory, as well as mental and motor speed are important domains in determining caregivers’ emotional health. Interventions to help caregivers cope with patient deficits in these areas have the potential to improve caregivers’ emotional health.
ATRA Upregulates Cell Surface CD1D on Myeloma Cells and Sensitizes Them to iNKT Cell-Mediated Lysis
Authors: Xin Li, Tarun K. Garg, Sarah K. Johnson, Susann Szmania, Justin Stivers, Wen Ling, Sharmin Khan, Priyangi Malaviarachchi, Bart Barlogie, Frits van Rhee, Shmuel Yaccoby
Journal: Blood (2014)
P26 CT abdomen and pelvis for unprovoked pulmonary embolism – what is the best practice?
Authors: R Wahida, S Ahmad, B Saunders, N How, M Anwar
Journal: Thorax (2016)

<h3>Background</h3> NICE guidelines advocate further investigations for cancer with an abdomino-pelvic CT scan (CT A/P) in all patients aged over 40 years with a first unprovoked deep vein thrombosis (DVT) or pulmonary embolism (PE) who do not have signs or symptoms of cancer based on initial investigation.<sup>1</sup> Recent prospective study showed no difference between ‘limited’ screening and CT A/P in diagnosing occult cancer.<sup>2</sup> We aimed to establish whether the number of new malignancies detected justified the risk of radiation exposure from performing a CT A/P in patient with unprovoked PE. <h3>Methods</h3> We performed a retrospective analysis of all CT Pulmonary Angiograms (CTPA) performed during a one year period (2014–2015) in a district general hospital. Records of those patients with confirmed pulmonary embolism on CTPA (n = 254) were examined to ascertain whether performing CT A/P increased the detection rate of occult malignancy. <h3>Results</h3> 124 (49%) out of a total 254 patients had an acute unprovoked PE. Of these, 6 patients were under the age of 40 years. Out of the remaining 118 patients, 80 (68%) patients underwent CT A/P. Unexpected malignancy was found in 3 (4%) of these 80 patients. No evidence of malignancy has been found in those patients that did not undergo CT A/P (n = 38) so far based on the follow up clinical encounters – both as an in-patient and outpatient. <h3>Conclusion</h3> Our data support the finding that the routine use of CT A/P in patients with unprovoked PE doesn’t detect significant number of occult malignancies. <h3>References</h3> Singh B, <i>et al</i>. <i>National institute for health and care excellence</i>. Venous thromboembolic diseases: diagnosis, management and thrombophilia testing. Nov 2012. Carrier M, <i>et al</i>. Screening for occult cancer in unprovoked venous thromboembolism. <i>NEJM</i> 2015;<b>373</b>:8.
P3.02b-102 Osimertinib Benefit in ctDNA T790M Positive, EGFR-Mutant NSCLC Patients
Authors: Jordi Remon, Caroline Caramella, Cecile Joelet, Ludovic Lacroix, Andrew Lawson, Sarah Smalley, Karen Howarth, Davina Gale, Nitzan Rosenfeld, Emma Green, Vincent Plagnol, David Planchard, Maria Bluthgen, Annas Gazzah, Chloe Pannet, Claudio Nicotra, Jean-Charles Soria, Benjamin Besse
Journal: Journal of Thoracic Oncology (2017)
Bortezomib Therapy Alone and in Combination with Dexamethasone for Patients with Previously Untreated Multiple Myeloma.
Authors: Sundar Jagannath, B. Durie, J. Wolf, E. Camacho, D. Irwin, J. Lutzky, M. McKinley, E. Gabayan, A. Mazumder, J. Crowley, R. Vescio, D. Schenkein
Journal: Blood (2005)
The Effectiveness and Value of Palliative Care in the Outpatient Setting
Authors: Courtney Cunningham, Daniel Ollendorf, Karin Travers
Journal: JAMA Internal Medicine (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
OA20.05 The Influence of Neoadjuvant Chemotherapy, on Immune Response Profile in Non-Small Cell Lung Carcinomas
Authors: Edwin Parra, Jaime Rodriguez-Canales, Carmen Behrens, Mei Jiang, Apar Pataer, Arelene Correa, Stephen Swisher, Boris Sepesi, Annikka Weissferdt, Neda Kalhor, William William, Jack Lee, John Heymach, Cesar Moran, Jianjun Zhang, Don Lynn Gibbons, Ignacio Wistuba
Journal: Journal of Thoracic Oncology (2017)
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7
Authors: Yang Luo, Katrina M de Lange, Luke Jostins, Loukas Moutsianas, Joshua Randall, Nicholas A Kennedy, Christopher A Lamb, Shane McCarthy, Tariq Ahmad, Cathryn Edwards, Eva Goncalves Serra, Ailsa Hart, Chris Hawkey, John C Mansfield, Craig Mowat, William G Newman, Sam Nichols, Martin Pollard, Jack Satsangi, Alison Simmons, Mark Tremelling, Holm Uhlig, David C Wilson, James C Lee, Natalie J Prescott, Charlie W Lees, Christopher G Mathew, Miles Parkes, Jeffrey C Barrett, Carl A Anderson
Journal: Nature Genetics (2017)
P1.02-045 Discordance (FISH+, IHC-) between FISH and IHC Analysis of ALK Status in Advanced Non-Small Cell Lung Cancer (NSCLC): A Unexpected Issue in 7 Cases
Authors: Anna Scattone, Stella Petroni, Anita Mangia, Annamaria Catino, Domenico Galetta, Laura Schirosi, Lucia Caldarola, Elisabetta Sara Montagna, Dario De Ceglia, Pia Perrotti, Giovanni Simone
Journal: Journal of Thoracic Oncology (2017)
P3.03-003 Mesothelium Covering Pleural Plaque Is Not Primarily Involved in Asbestos-Induced Mesothelial Carcinogenesis in Human
Authors: Yuichi Koda, Kozo Kuribayashi, Shingo Kanemura, Eisuke Shibata, Taiichiro Otsuki, Koji Mikami, Takashi Nakano
Journal: Journal of Thoracic Oncology (2017)