Digoxin-Quinidine Interaction
Authors: J. ROBERT POWELL
Journal: Annals of Internal Medicine (1981)

Letters and Corrections1 April 1981Digoxin-Quinidine InteractionJ. ROBERT POWELL, PHARM.D., PAUL E. FENSTER, M.D., W. DAVID HAGER, M.D.J. ROBERT POWELL, PHARM.D.Search for more papers by this author, PAUL E. FENSTER, M.D.Search for more papers by this author, W. DAVID HAGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-94-4-540_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Mungall and associates (1) presented data which quantitate both the time course of the digoxin-quinidine interaction, and the magnitude of change in digoxin renal clearance induced by quinidine. We (2) and others (3) agree with the conclusions by Mungall and associates that digoxin levels achieve near steady state 6 days after starting quinidine therapy and that digoxin renal clearance is reduced by quinidine. We do, however, have several questions about the interpretation of some of the results.Patients 4 and 11 had creatinine clearances in the 20 to 30 mL/min. range. Collection of trough digoxin samples for...References1. MUNGALL D, ROBICHAUX R, PERRY W, SCOTT J, ROBINSON A, BURELLE T, and HURST D. Effect of quinidine on serum digoxin concentration. Ann Intern Med. 1980;93:689-93. LinkGoogle Scholar2. POWELL J, FENSTER P, WANDELL M, HAGER D, GRAVES P, and GOLDMAN S. Quinidine-digoxin interaction: multiple-dose pharmacokinetics. Clin Pharmacol Ther. 1980;27:279. Abstract. Google Scholar3. DOERING W. Quinidine-digoxin interaction: pharmacokinetics, underlying mechanism, and clinical implications. N Eng J Med. 1979;301:400-4. CrossrefMedlineGoogle Scholar4. GIBALDI M, LEVY G, and MCNAMARA P. Effects of plasma protein and tissue binding on the biologic half-life of drugs. Clin Pharmacol Ther. 1979;24:1-4. CrossrefGoogle Scholar5. WILKINSON G and SHAND D. A physiologic approach to hepatic drug clearance. Clin Pharmacol Ther. 1975;18:377-90. CrossrefMedlineGoogle Scholar1. KOUP J, JUSKO W, ELWOOD C, and KOHLI R. Digoxin pharmacokinetics: role of renal failure in dosage regimen design. Clin Pharmacol Ther 1975;18:9-21. CrossrefMedlineGoogle Scholar2. JUSKO W, SZEFLER S, and GOLDFARB A. Pharmacokinetic design of digoxin dosage regimens in relation to renal function. J Clin Pharmacol. 1974;14:525-35. CrossrefMedlineGoogle Scholar3. HALKIN H, SKEINER L, PECK C, and MELMON K. Determinants of the renal clearance of digoxin. Clin Pharmacol Ther. 1975;17:385-94. CrossrefMedlineGoogle Scholar4. HAGER W, FENSTER P, and MAYERSOHN M: Digoxin-quinidine interaction: pharmacokinetic evaluation. N Engl J Med. 1979;300:1238-41. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: J. ROBERT POWELL, PHARM.D.; PAUL E. FENSTER, M.D.; W. DAVID HAGER, M.D. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe influence of quinidine and other agents on digitalis glycosides 1 April 1981Volume 94, Issue 4_Part_1Page: 540-540KeywordsCreatinine ePublished: 1 December 2008 Issue Published: 1 April 1981 PDF downloadLoading ...