tbuckley/cabot-search huggingface dataset:
Pneumatosis coli as a rare complication of bowel preparation
Authors: T. Rath, E. Roeb, W. Doppl
Journal: Endoscopy (2010)

Intestinal lavage for colonoscopy is a safe procedure, even in elderly patients [1]. This is the first report describing a case of acute ischemic colitis with pneumatosis coli resulting from bowel preparation in a patient with anatomic predispositions.
Endoscopic and transabdominal color doppler ultrasound in diagnosis of common bile duct varices in patients with portal vein thrombosis
Authors: I Grgurevic, Z Babic, M Banic, Z Cabrijan, D Kardum, M Kujundzic, I Lesnjakovic, M Tadic, M Urek, B Brkljacic
Journal: Endoscopy (2006)

Background: Portal vein thrombosis (PVT) leads to cavernoma formation which is usually localized at the porta hepatis. A few literature reports also describe collateral venous circulation involving extrahepatic bile ducts in form of paracholedocal varices (PCV) or common bile duct (CBD) wall thickening due to dilation of intramural veins (IMV).
News Cancer Cases and Deaths: 1991 Estimates
Authors: B. K. Edwards
Journal: JNCI Journal of the National Cancer Institute (1991)

News Cancer Cases and Deaths: 1991 Estimates Get access Brenda K. Edwards, Ph.D. Brenda K. Edwards, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Page 745, https://doi.org/10.1093/jnci/83.11.745 Published: 05 June 1991
PWE-216 Diagnostic accuracy for detection of dysplasia in Barrett's oesophagus using narrow band imaging with magnification improves after a short training session in those with prior exposure to NBI but not in novices: Abstract PWE-216 Table 1
Authors: V Subramanian, K Ragunath
Journal: Gut (2012)

<h3>Introduction</h3> Narrow band imaging (NBI) with magnification (NBI-zoom) has been shown to be highly sensitive and specific in identifying dysplasia in Barrett9s oeosphagus (BO). These studies have been done using experts and there is limited data on how these techniques can be taught. Recently studies have demonstrated that identifying adenomatous pit patterns in colonic polyps using NBI can be easily taught by short training sessions. The aim of this study was to prospectively evaluate the utility of a short training session on the ability of endoscopists to identify dysplastic patterns in NBI-zoom images from patients with BO. <h3>Methods</h3> A prospective observational study was done on 28 endoscopists (10 novices, 10 with prior exposure to NBI and 10 experienced in the use of NBI-zoom) who attended a national level symposium on BO. A pre-test with 15 NBI-zoom images was followed by a 15 min training session where the endoscopic criteria for making a diagnosis of dysplasia on NBI-zoom images were described and demonstrated. The post-test had 25 NBI-zoom images. Images were projected using a high definition projector system and participants were given 45 s per image to make a diagnosis. Overall accuracy in detecting dysplasia was calculated and the inter-observer reliability of the groups was determined using bias corrected κ statistics. <h3>Results</h3> Abstract PWE-216 table 1 provides the accuracy of classification of mucosal and vascular patterns and identifying the presence of dysplasia in the three groups of endoscopists. Significant improvement was noted after the training session in the group with prior NBI exposure but not in novices. The κ value for inter-observer reliability significantly (p=0.01) improved among those with prior NBI exposure from 0.238 (0.082–0.453) to 0.650 (0.421–0.836) after the training sessions but not in novices (p=0.4) 0.280 (0.084–0.532) to 0.374 (0.251–0.517) or experienced endoscopists (p=0.08) 0.505 (0.273–0.708) to 0.779 (0.552–0.929). <h3>Conclusion</h3> A short didiactic teaching session can achieve high accuracy and good interobsever agreement in identifying dysplastic patterns in NBI-zoom images from BO in those with some prior NBI experience but not in novices. <h3>Competing interests</h3> V Subramanian: None declared, K Ragunath Grant/Research Support from: Olympus Medical.
THE ASSOCIATION BETWEEN LEFT VENTRICULAR MASS AND MEASURES OF INFARCT SIZE IN ANTERIOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: INSIGHTS FROM THE EMBRACE STEMI CLINICAL TRIAL
Authors: Yazan Daaboul, Serge Korjian, W. Douglas Weaver, Robert Kloner, Robert Giugliano, Jim Carr, Brandon J. Neal, Gerald Chi, Madeleine Cochet, Laura Goodell, Nathan Michalak, Luke Rusowicz-Orazem, Turky Alkathery, Haytham Allaham, Maliha Shakil, Donald Szlosek, C. Michael Gibson
Journal: Journal of the American College of Cardiology (2016)
Circulating Activated Suppressor T Lymphocytes in Aplastic Anemia
Authors: Nicholas C. Zoumbos, Pedro Gascón, Julie Y. Djeu, Stephen R. Trost, Neal S. Young
Journal: New England Journal of Medicine (1985)

We studied the mechanism of hematopoietic suppression in aplastic anemia by means of two-color flow microfluorometric analysis of lymphocyte subpopulations and correlated the results with the occurrence in vitro of hematopoietic suppression and interferon production. In 12 patients with aplastic anemia a striking increase was observed in a population of "activated" suppressor T lymphocytes, which were defined by binding of both anti-Leu-2 and anti-HLA-DR monoclonal antibodies (patients with aplastic anemia, 6.8 +/- 3.2 per cent [mean +/- S.D.]; normal subjects, 1.7 +/- 1.3; patients given multiple transfusions, 2.5 +/- 1.7). Tac antigen expression, another surface marker of lymphocyte activation, was increased on suppressor lymphocytes in all five patients examined (patients with aplastic anemia, 31 +/- 17 per cent; normal subjects, 0.7 +/- 0.24; patients given multiple transfusions, 2.3 +/- 1.2). When Tac+ and Tac- cells were separated in a cell sorter, only Tac+ cells produced interferon. When lymphocytes of patients with aplastic anemia were cocultured with normal bone marrow, only the Tac+ cell fraction showed hematopoietic suppressor activity. In one patient, in vitro elimination of suppressor lymphocytes by use of OKT8 antibody abolished spontaneous interferon production by bone-marrow cells. These results suggest that activated suppressor lymphocytes producing interferon have a role in the pathogenesis of bone-marrow failure, and indicate the usefulness of defined lymphokine and phenotypic markers in the study of aplastic anemia.
FRI0110 A Phase I Pharmacokinetic Study Comparing SB5, An Adalimumab Biosimilar, And Adalimumab Reference Product (Humira®) in Healthy Subjects: Table 1.
Authors: D. Shin, Y. Kim, H.S. Kim, R. Fuhr, T. Körnicke
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> SB5, a biosimilar to adalimumab reference product (ADL), has an identical amino acid sequence, similar physicochemical and <i>in vitro</i> functional properties to its reference drug. <h3>Objectives</h3> The primary objective of this study was to demonstrate pharmacokinetic (PK) equivalence between SB5 and EU sourced ADL (EU-ADL), SB5 and US sourced ADL (US-ADL), and between EU-ADL and US-ADL. Safety, tolerability, and immunogenicity were investigated as secondary objectives. <h3>Methods</h3> This study was a randomised, single-blind, 3-arm, parallel group study in 189 healthy subjects. In each arm, all subjects received a single 40 mg dose of SB5, EU-ADL, or US-ADL by subcutaneous injection on Day 1 and then were observed for 71 days during which the PK, safety, tolerability, and immunogenicity measurements were made. The serum concentration of adalimumab was measured using an enzyme-linked immunosorbent assay (ELISA). The primary PK parameters were area under the concentration-time curve from time zero to infinity (AUC<sub>inf</sub>), area under the concentration-time curve from time zero to the last quantifiable concentration (AUC<sub>last</sub>), and maximum concentration (C<sub>max</sub>). Equivalence for the primary PK parameters was to be concluded if the 90% confidence intervals (CIs) for the ratio of geometric least squares means (LSMeans) of the groups compared were completely contained within the pre-defined equivalence margin of 0.8 to 1.25 using an analysis of variance (ANOVA). <h3>Results</h3> All of the 90% CIs for the geometric LSMeans ratios of primary PK parameters for SB5 and EU-ADL comparison, SB5 and US-ADL comparison, and EU-ADL and US-ADL comparison were within the pre-defined equivalence margin of 0.8 to 1.25 (Table). The proportion of subjects who experienced treatment-emergent adverse events (TEAEs) was comparable between the SB5, EU-ADL, and US-ADL groups. The most frequent TEAEs were nasopharyngitis and headache. The majority of TEAEs were mild to moderate in severity. Two serious adverse events (SAEs) were reported. Both SAEs were assessed not to be related to the study drugs. There were no statistically significant differences in the incidence of post-dose anti-drug antibodies between the three groups. <h3>Conclusions</h3> This study demonstrated PK equivalence between SB5 and EU-ADL, SB5 and US-ADL, and between EU-ADL and US-ADL in healthy subjects. All three adalimumab products were generally well tolerated with similar safety profiles. <h3>Disclosure of Interest</h3> D. Shin Employee of: Samsung Bioepis, Y. Kim Employee of: Samsung Bioepis, H. S. Kim Employee of: Samsung Bioepis, R. Fuhr Grant/research support from: Samsung Bioepis, T. Körnicke Grant/research support from: Samsung Bioepis
Congenital Heart Disease in Adults
Authors: M. Elizabeth Brickner, L. David Hillis, Richard A. Lange
Journal: New England Journal of Medicine (2000)

Over the past 20 to 30 years, major advances have been made in the diagnosis and treatment of congenital heart disease in children. As a result, many children with such disease now survive to adulthood. In the United States alone, the population of adults with congenital heart disease, either surgically corrected or uncorrected, is estimated to be increasing at a rate of about 5 percent per year; this year there will be almost 1 million such patients.1 This two-part review discusses the more common acyanotic and cyanotic congenital heart conditions that physicians who care for adults are likely to encounter. . . .
Oral D-Xylose Test in Healthy Infants and Children
Authors: P. Lanzkowsky, M. Madenlioglu, J. F. Wilson, M. E. Lahey
Journal: New England Journal of Medicine (1963)

THE purpose of this paper is to report values for the so-called xylose tolerance test in a group of healthy infants and children at different ages. We have chosen to designate this test the oral D-xylose test, for reasons discussed below.Xylose is absorbed chiefly in the duodenum and proximal jejunum, and since it is a simple sugar, digestion is unnecessary and absorption is independent of bile, intestinal or pancreatic secretions. The primary use of this test, therefore, is in the demonstration of malabsorption states arising from lesions involving the upper small-bowel wall, such as gluteninduced enteropathy. This procedure, first . . .
Herpes Simplex Viral and Amplicon Vector-Mediated Gene Transfer into Glia and Neurons in Organotypic Spinal Cord and Dorsal Root Ganglion Cultures
Authors: Daniel R. Marsh, Gregory A. Dekaban, Wei Tan, Craig A. Strathdee, Lynne C. Weaver
Journal: Molecular Therapy (2000)

The progression of neurodegenerative diseases and secondary consequences of spinal cord injury may be diminished by introducing transgenes to glia, spinal neurons, and/or sensory neurons. Organotypic cultures of spinal cord slices and dorsal root ganglia proved to be an excellent system in which to compare the relative neurotropism of a replication-defective recombinant herpes simplex virus and herpes virus-derived amplicon vectors. Hundreds of β-galactosidase-expressing cells, transduced by the viral vectors, were observed in spinal cord slices 3 and 8 days postinfection. Immunostaining to identify the infected cell type indicated that oligodendrocytes were permissive for viral vector transduction of β-galactosidase in the spinal cord slice, whereas neurons were not. Heparan sulfate proteoglycan, the initial receptor for herpes contact with cells, was highly expressed in the white matter of the spinal cord slice, but was negligible in the gray matter. In contrast to the spinal cord, many fewer cells were infected in the dorsal root ganglia (DRG) by these vectors, but a majority of infected cells were identified as sensory neurons. Heparan sulfate proteoglycan expression was abundant in the sensory fibers emanating from the DRG and also surrounded each neuron within the ganglion. Our results demonstrate HSV-induced transgene expression that is amenable to ex vivo assessment of its physiological impact. The progression of neurodegenerative diseases and secondary consequences of spinal cord injury may be diminished by introducing transgenes to glia, spinal neurons, and/or sensory neurons. Organotypic cultures of spinal cord slices and dorsal root ganglia proved to be an excellent system in which to compare the relative neurotropism of a replication-defective recombinant herpes simplex virus and herpes virus-derived amplicon vectors. Hundreds of β-galactosidase-expressing cells, transduced by the viral vectors, were observed in spinal cord slices 3 and 8 days postinfection. Immunostaining to identify the infected cell type indicated that oligodendrocytes were permissive for viral vector transduction of β-galactosidase in the spinal cord slice, whereas neurons were not. Heparan sulfate proteoglycan, the initial receptor for herpes contact with cells, was highly expressed in the white matter of the spinal cord slice, but was negligible in the gray matter. In contrast to the spinal cord, many fewer cells were infected in the dorsal root ganglia (DRG) by these vectors, but a majority of infected cells were identified as sensory neurons. Heparan sulfate proteoglycan expression was abundant in the sensory fibers emanating from the DRG and also surrounded each neuron within the ganglion. Our results demonstrate HSV-induced transgene expression that is amenable to ex vivo assessment of its physiological impact.
Influence of food-environment interactions on health in the twenty-first century.
Authors: O Fennema
Journal: Environmental Health Perspectives (1990)

The quality and safety of foods are affected by the environment, and the quality and safety of the environment are, in turn, affected by foods and food processing. To explore these interrelationships, as they might exist in the twenty-first century, one must speculate regarding future changes in foods and food processing. Several trends in food processing seem likely to predominate into the twenty-first century, and they will be, for the most part, evolutionary in nature and of low consumer visibility. These trends are greater use of foods marketed in a refrigerated state, greater use of irradiation and combination processes, greater automation and optimization of processes, and greater use of biotechnology. It is also reasonable to assume that food products of the following types will increase in importance, namely, those that are convenient (includes eating away from home), those that are tailored to specific dietary needs, those containing chemically modified components such as altered proteins and carbohydrates, and fabricated foods. If these trends in foods and food processes prevail then concern must be directed to the following areas: Microbiological concerns--refrigerated foods; food service operations; new or altered procedures for processing, handling and storing foods; and new foods or food formulations; attention must be given both to controlling known pathogens as well as newly perceived pathogens. Chemical concerns--toxicants occurring naturally in foods; contaminants; chemicals developing in foods during processing, handling and storage; chemicals used in fabricated foods; and chemicals of newly perceived importance, especially those having adverse, covert effects. Several of these chemical concerns are influenced in seriousness by composition of the food environment.
Abstract 2678: Molecular signature of drug action for microtubule stabilizing agents
Authors: Marina Khrapunovich-Baine, Vilas Menon, Andras Fiser, Ruth Hogue Angeletti, Susan Band Horwitz, Hui Xiao
Journal: Cancer Research (2010)

Abstract Microtubule-stabilizing agents (MSAs) comprise a class of drugs that bind to polymerized microtubules (MTs), thereby inhibiting their dynamic properties and leading to arrest in mitosis. The prototype of this group of drugs, Taxol, is an effective chemotherapeutic agent used extensively in the treatment of human ovarian, breast, and lung carcinomas. Although electron crystallography and photoaffinity labeling studies led to the identification of the binding site for Taxol in the β-tubulin subunit of the MT polymer, the effect of the drugs on MT conformation was only recently deciphered in our laboratory using hydrogen deuterium exchange (HDX) coupled to high-pressure liquid chromatography and mass spectrometry (HPLC-MS). We have also utilized this technique to determine the binding mode and conformational effects of discodermolide, another MSA with potential to become a useful anti-tumor drug. We found that in tubulin isolated from chicken erythrocytes, discodermolide bound to an overlapping binding site with Taxol, but had a distinct pose within the pocket, such that it oriented itself away from the M-loop and toward the N-terminal H1-S2 loop of β-tubulin. Evidence of conformational effects on the C-terminal H12 helix in the α-tubulin subunit and of complementary MT stabilization between Taxol and discodermolide was found. These results provide the molecular basis for the ability of the two drugs to modulate interactions with endogenous microtubule associated proteins (MAPs) and for the synergy observed between them in vivo. Preliminary analysis of the data with four other MSAs, epothilone B, ixabepilone, peloruside A, and laulimalide, suggests a very similar mode of MT stabilization by all the drugs in this class, with some drug-specific, and more importantly, binding-mode-specific MT-stabilizing effects. Careful examination and qualitative comparison of the conformational effects of all the aforementioned MSAs is currently in progress, and will allow us to determine a molecular signature for drug action that may correlate with the corresponding therapeutic benefits. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2678.
Retrieval of proximally migrated plastic biliary stents using a metal stent
Authors: M. Vázquez Rey, B. González Conde, P. Alonso Aguirre, I. Couto Wörner, E. Estévez Prieto, B. Crespo Suárez, A. Salazar Laya
Journal: Endoscopy (2011)

The use of endoscopic stents is common in the treatment of biliary tract stenosis. However, the proximal migration of these stents occasionally results in complications that are difficult to manage [1]. Various techniques for stent retrieval have been described, including the use of Dormia baskets, rat-tooth forceps, a balloon, or Soehendra-type stent retrievers [2]. This paper presents a new technique for the retrieval of proximally migrated plastic biliary stents.
AB0416 Clinical and immunological association with autoantibodies to cellular antigen in a cohort of 532 sle patients from a single center.
Authors: M. Fredi, I. Cavazzana, S. Cartella, A. Tincani, F. Franceschini
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> autoantibodies (autoabs) to cellular antigens can be associated with specific clinical and immunological subsets of Systemic Lupus Erythematosus (SLE). <h3>Objectives</h3> to analize the frequencies of different autoabs detected by counterimmunoelectrophoresis (CIE) and to describe clinical and immunological associations in a SLE cohort of patients. <h3>Methods</h3> clinical and serological features about our cohort of SLE were collected from clinical charts. Antinuclear antibodies were detected by indirect immunofluorescence (IIF) on HEp2 cells, anti extractable nuclear antigen (ENA) by CIE using rabbit thymus and human spleen as substrate and anti-dsDNA by FARR assay. Anticardiolipin and anti-B2glycoprotein I were detected by ELISA. For statistical analysis was used Chi-squared or Fisher exact test and student t test. Multivariate analysis was performed using logistic regression model <h3>Results</h3> we collected complete data from 532 SLE patients (pts), classified according to revised ACR criteria. Mean age at onset was 33.8 years, mean follow-up 10 years. They showed a female to male ratio of 12:1, mostly were Caucasians (96.4%). Among our pts 235 (44.1%)were positive for anti-Ro/SSA antibodies,45 (8.4%)anti-Sm, 69(12.9%) U1RNP, 31(5.8%) anti-Ki, 8 (1.5%) anti-Ku, 4(0.7%) anti-centromere, 3(0.5%) anti-Scl70, 2(0.3%) Jo-1 and PCNA antibodies respectively. Clinical or serological features that show statistical significative association with one antibody specificity are reported in table 1. We studied features associated with multiple antibodies with multivariate analysis, anti-U1RNP and anti-Ro/SSA resulted to be associated with malar rash (p=0.009 and 0.02respectively) and anti-U1RNP with leukopenia (p=0.0055). Patients with antibodies considered to be diagnostic markers for other connective tissue disease, such as anti-Scl70, anti-centromere and anti-Jo-1 were evaluated for overlap disease. Only 2pts anti-Scl70 positive satisfied classification criteria both for SLE and systemic sclerosis. <h3>Conclusions</h3> in our cohort of SLE pts we observed several statistical significative associations between clinical and serological features and autoabs. These associations can be found both with common autoabs, but also with more rare one. In particular we confirmed association between anti-Ki antibodies and SLE male gender. We reported a new association between anti-Ku antibodies and African SLE pts. <h3>Disclosure of Interest</h3> None Declared
Abstract 20: GIST-specific markers identified by comprehensive gene expression profiles.
Authors: Manabu Iwadate, Kohtaro Miyamoto, Emi Ito, Jun-ichi Imai, Naoki Sawada, Izumi Nakamura, Shinji Ohki, Shinya Watanabe, Satoshi Waguri, Seiichi Takenoshita
Journal: Cancer Research (2013)

Abstract Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasm of the gastrointestinal tract and highly express c-kit. Although surgical removal and molecularly targeted therapy are known to be effective, specific markers other than c-kit would be beneficial for histopathological classification, risk assessment, and treatment decision. To this end, we conducted a DNA-microarry analysis using approximately 900 tumor tissues obtained in Fukushima Medical University Hospital from 2007 to present. The database contained more than 30 kinds of tumors including 10 cases of GIST. We searched ∼32,000 genes on the array that showed expression ratio of &amp;gt;2.0 in GIST samples compared to others, and finally extracted 54 GIST-specific genes. In this study, we identified that cathepsin L mRNA is highly expressed in GISTs. Moreover, immunohistochemical analysis of 43 GIST specimens revealed that 86.0% (n = 37) were cathepsin-L positive, and this positivity was significantly correlated with c-kit positivity. From these results, we conclude that cathepsin L is highly expressed in GISTs. Citation Format: Manabu Iwadate, Kohtaro Miyamoto, Emi Ito, Jun-ichi Imai, Naoki Sawada, Izumi Nakamura, Shinji Ohki, Shinya Watanabe, Satoshi Waguri, Seiichi Takenoshita. GIST-specific markers identified by comprehensive gene expression profiles. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 20. doi:10.1158/1538-7445.AM2013-20