tbuckley/cabot-search huggingface dataset:
Early Evidence of Anti-Lymphoma Activity of the Cyclin Dependent Kinase Inhibitor Dinaciclib (SCH 727965) In Heavily Pre-Treated Low Grade Lymphoma and Diffuse Large Cell Lymphoma Patients
Authors: Robert A Baiocchi, Joseph M. Flynn, Jeffrey A. Jones, Kristie A. Blum, Craig C. Hofmeister, Jennifer Poon, Karen Small, Paul Statkevich, Michael R. Grever, Rajat Bannerji, John C. Byrd
Journal: Blood (2010)
Evaluation of Type Replacement Following HPV16/18 Vaccination: Pooled Analysis of Two Randomized Trials
Authors: Joseph E. Tota, Frank Struyf, Marko Merikukka, Paula Gonzalez, Aimée R. Kreimer, Dan Bi, Xavier Castellsagué, Newton S. de Carvalho, Suzanne M. Garland, Diane M. Harper, Naveen Karkada, Klaus Peters, Willy A. J. Pope, Carolina Porras, Wim Quint, Ana Cecilia Rodriguez, Mark Schiffman, John Schussler, S. Rachel Skinner, Júlio Cesar Teixeira, Allan Hildesheim, Matti Lehtinen
Journal: JNCI Journal of the National Cancer Institute (2016)

Current HPV vaccines do not protect against all oncogenic HPV types. Following vaccination, type replacement may occur, especially if different HPV types competitively interact during natural infection. Because of their common route of transmission, it is difficult to assess type interactions in observational studies. Our aim was to evaluate type replacement in the setting of HPV vaccine randomized controlled trials (RCTs).Data were pooled from the Costa Rica Vaccine Trial (CVT; NCT00128661) and PATRICIA trial (NCT001226810)-two large-scale, double-blind RCTs of the HPV-16/18 AS04-adjuvanted vaccine-to compare cumulative incidence of nonprotected HPV infections across trial arms after four years. Negative rate difference estimates (rate in control minus vaccine arm) were interpreted as evidence of replacement if the associated 95% confidence interval excluded zero. All statistical tests were two-sided.After applying relevant exclusion criteria, 21 596 women were included in our analysis (HPV arm = 10 750; control arm = 10 846). Incidence rates (per 1000 infection-years) were lower in the HPV arm than in the control arm for grouped nonprotected oncogenic types (rate difference = 1.6, 95% confidence interval [CI] = 0.9 to 2.3) and oncogenic/nononcogenic types (rate difference = 0.2, 95% CI = -0.3 to 0.7). Focusing on individual HPV types separately, no deleterious effect was observed. In contrast, a statistically significant protective effect (positive rate difference and 95% CI excluded zero) was observed against oncogenic HPV types 35, 52, 58, and 68/73, as well as nononcogenic types 6 and 70.HPV type replacement does not occur among vaccinated individuals within four years and is unlikely to occur in vaccinated populations.
Crosslineage T-Cell Receptor Genes Rearrangements and Active Receptor Editing in B-Cell Acute Lymphoblastic Leukemia.
Authors: Hanna Makuch-Lasica, Miroslaw Majewski, Grazyna Nowak, Monika Lewandowska, Iwona Solarska, Iwona Kania, Krzysztof Warzocha
Journal: Blood (2006)
Optimal sequencing of ibrutinib, idelalisib, and venetoclax in chronic lymphocytic leukemia: results from a multicenter study of 683 patients
Authors: A.R. Mato, B.T. Hill, N. Lamanna, P.M. Barr, C.S. Ujjani, D.M. Brander, C. Howlett, A.P. Skarbnik, B.D. Cheson, C.S. Zent, J.J. Pu, P. Kiselev, K. Foon, J. Lenhart, S. Henick Bachow, A.M. Winter, A.-L. Cruz, D.F. Claxton, A. Goy, C. Daniel, K. Isaac, K.H. Kennard, C. Timlin, M. Fanning, L. Gashonia, M. Yacur, J. Svoboda, S.J. Schuster, C. Nabhan
Journal: Annals of Oncology (2017)
Ultra-Deep Sequencing Strategy Is a Precious Tool to Find Small Clones Harbouring FLT3 Mutations in AML Patients
Authors: Elisa Zuffa, Eugenia Franchini, Cristina Papayannidis, Carmen Baldazzi, Nicoletta Testoni, Federica Cattina, Maria Chiara Abbenante, Stefania Paolini, Ilaria Iacobucci, Viviana Guadagnuolo, Antonella Padella, Giorgia Simonetti, Emanuela Ottaviani, Giovanni Martinelli
Journal: Blood (2014)
A Phase II Trial of Combination Therapy with Thalidomide, Arsenic Trioxide, Dexamethasone, and Ascorbic Acid (TADA) in Patients with Overlap Myelodysplastic/Myeloproliferative Diseases (MDS/MPD) or Chronic Idiopathic Myelofibrosis (CIMF).
Authors: Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Matt Kalaycio, Mary Laughlin, Ronald Sobecks, Anjali Advani, Katarina Paulic, Josephine Chan, Alison Vellani, Azra Raza
Journal: Blood (2007)
High Frequency of Marginal Zone Lymphomas Among Patients Coinfected with Human Immunodeficiency Virus and Hepatitis C Virus - ANRS CO16 LYMPHOVIR Cohort Study
Authors: Benjamin Terrier, Dominique Costagliola, Houria Chavez, Danielle Canioni, Régis Costello, Lilia Escaut, Bertrand Joly, Lorraine Le Tranchant, Pascale Morineau-Le Houssine, Anne Simon, Yassine Taoufik, Sophie Prevot, Patrice Cacoub, Martine Raphael, Caroline Besson
Journal: Blood (2010)
ZAP-70 Expression Evaluated by Mean Fluorescence Intensity T/B Ratio Is a More Useful Prognosticator Than Percentage of Positive Cells in Chronic Lymphocytic Leukemia (CLL).
Authors: Francesca Maria Rossi, Maria Ilaria Del Principe, Davide Rossi, Maria Irno Consalvo, Fabrizio Luciano, Antonella Zucchetto, Pietro Bulian, Riccardo Bomben, Dania Benedetti, Michele Dal-Bo, Massimo Degan, Gianluca Gaidano, Giovanni Del Poeta, Valter Gattei
Journal: Blood (2009)
Left ventricular filling pattern in congestive heart failure patients with normal sinus rhythm. A decreased ratio of peak mitral flow velocity in atrial systole relative to that in early diastole may reflect markedly increased left ventricular end-diastolic pressure.
Authors: Kanji Iga, Kenjiro Hori, Tadashi Matsumura, Go Tomonaga, Hiromitsu Gen, Toshitake Tamamura
Journal: Circulation (1990)

The left ventricular filling pattern was studied by pulsed Doppler echocardiography in 13 congestive heart failure patients with normal sinus rhythm. The first study was done when congestive heart failure was present; the second after the signs and symptoms of congestive heart failure disappeared. In 12 of the 13 patients, the peak mitral flow velocity in atrial systole (PFVA) increased after the congestive heart failure disappeared (mean increase from 50.5 cm/sec to 74.8 cm/sec : p = 0.0001, paired t test), and the peak mitral flow velocity in early diastole (PFVE) decreased significantly in all 8 patients in whom secondary mitral regurgitation became less severe after improvement of congestive heart failure (mean decrease from 90.8 cm/ sec to 52.0 cm/sec : p = 0.0001, paired t test). The ratio of PFVA to PFVE (PFVA/PFVE) increased in all cases after the congestive heart failure improved (mean increase from 0.59 to 1.33 : p = 0.0001, paired t test). The PFVA/PFVE is a simple index of left ventricular diastolic function. A PFVA/PFVE greater than one indicates disturbed left ventricular diastolic function. However, when the' PFVA/PFVE is in a normal range for the patients' age (pseudo-normalization) and is accompanied by impaired left ventricular systolic function in congestive heart failure, markedly increased left ventricular end-diastolic pressure must be considered.
Multicomponent Injectable Hydrogels for Antigen‐Specific Tolerogenic Immune Modulation
Authors: Catia S. Verbeke, Susana Gordo, David A. Schubert, Sarah A. Lewin, Rajiv M. Desai, Jessica Dobbins, Kai W. Wucherpfennig, David J. Mooney
Journal: Advanced Healthcare Materials (2017)

Biomaterial scaffolds that enrich and modulate immune cells in situ can form the basis for potent immunotherapies to elicit immunity or reëstablish tolerance. Here, the authors explore the potential of an injectable, porous hydrogel to induce a regulatory T cell (Treg) response by delivering a peptide antigen to dendritic cells in a noninflammatory context. Two methods are described for delivering the BDC peptide from pore-forming alginate gels in the nonobese diabetic mouse model of type 1 diabetes: encapsulation in poly(lactide-co-glycolide) (PLG) microparticles, or direct conjugation to the alginate polymer. While particle-based delivery leads to antigen-specific T cells responses in vivo, PLG particles alter the phenotype of the cells infiltrating the gels. Following gel-based peptide delivery, transient expansion of endogenous antigen-specific T cells is observed in the draining lymph nodes. Antigen-specific T cells accumulate in the gels, and, strikingly, ≈60% of the antigen-specific CD4+ T cells in the gels are Tregs. Antigen-specific T cells are also enriched in the pancreatic islets, and administration of peptide-loaded gels does not accelerate diabetes. This work demonstrates that a noninflammatory biomaterial system can generate antigen-specific Tregs in vivo, which may enable the development of new therapies for the treatment of transplant rejection or autoimmune diseases.
Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2
Authors: Hua Wang, Haiyan Zhang, Qiuyi Sun, Yun Wang, Jun Yang, Jincheng Yang, Tao Zhang, Shenqiu Luo, Liping Wang, Yu Jiang, Chun Zeng, Daozhang Cai, Xiaochun Bai
Journal: Molecular Therapy (2017)

MicroRNAs (miRNAs) are emerging as important regulators in osteoarthritis (OA) pathogenesis. In our study, a real-time PCR assay revealed that miR-483-5p was upregulated in articular cartilage from OA patients and experimental OA mice induced by destabilization of the medial meniscus compared to their controls. Overexpression of miR-483-5p by intra-articular injection of lentivirus LV3-miR-483-5p significantly enhanced the severity of experimental OA. Consequently, we synthesized antago-miR-483-5p to silence the endogenous miR-483-5p and delivered it intra-articularly, which revealed that antago-miR-483-5p delayed the progression of experimental OA. To investigate the functional mechanism of miR-483-5p in OA development, we generated doxycycline-inducible miR-483 transgenic (TG483) mice. TG483 mice exhibited significant acceleration and increased severity of OA, and age-related OA occurred with higher incidence and greater severity in TG483 mice compared with their controls. Furthermore, our results revealed miR-483-5p directly targeted to the cartilage matrix protein matrilin 3 (Matn3) and tissue inhibitor of metalloproteinase 2 (Timp2) to stimulate chondrocyte hypertrophy, extracellular matrix degradation, and cartilage angiogenesis, and it consequently initiated and accelerated the development of OA. In conclusion, our findings reveal an miRNA functional pathway important for OA development. Targeting of miR-483-5p by intra-articular injection of antago-miR-483-5p represents an approach that could prevent the onset of OA and delay its progression.
Music therapy is a potential intervention for cognition of Alzheimer’s Disease: a mini-review
Authors: Rong Fang, Shengxuan Ye, Jiangtao Huangfu, David P. Calimag
Journal: Translational Neurodegeneration (2017)

Alzheimer's Disease (AD) is a global health issue given the increasing prevalence rate and the limitations of drug effects. As a consequent, non-pharmacological interventions are of importance. Music therapy (MT) is a non-pharmacological way with a long history of use and a fine usability for dementia patients. In this review, we will summarize different techniques, diverse clinical trials, and the mechanisms of MT as it is helpful to the cognition in AD, providing reference for future research. Many articles have demonstrated that MT can reduce cognitive decline especially in autobiographical and episodic memories, psychomotor speed, executive function domains, and global cognition. MT is a promising intervention for strategy of dementia especially of AD and it must be started as early as possible. However, more evidences with prospective, randomized, blinded, uniform and rigorous methodological investigations are needed. And we should consider to combine MT with other cognitive stimulations such as dance, physical exercise, video game, art and so on.
A Novel Non-Peptidyl Human C-Mpl Agonist, NIP-004, Stimulates Human Megakaryopoiesis and Thrombopoiesis.
Authors: Takanori Nakamura, Yoshitaka Miyakawa, Atsushi Miyamura, Akiko Yamane, Hidenori Suzuki, Katsuaki Miyaji, Mamoru Ito, Yasuyuki Ohnishi, Norihisa Ishiwata, Yasuo Ikeda, Nobutomo Tsuruzoe
Journal: Blood (2005)
Identification of a Novel Mode of Kinase Inhibitor Resistance: An F604S Exchange in FIP1L1-PDGFRA Modulates FIP1L1-PDGFRA Protein Stability in a SRC-Dependent Manner
Authors: Sivahari P. Gorantla, Nikolas von Bubnoff, Christian Peschel, Justus Duyster
Journal: Blood (2008)
Are Beta-Receptor and Angiotensin-Blocking Drugs Protective Against Venous Thromboembolism (VTE)? A Population Based Case-Control Study
Authors: Aneel A. Ashrani, Wencheng Geng, Daniel J. Crusan, Tanya M. Petterson, Kent R. Bailey, Cynthia L. Leibson, John A. Heit
Journal: Blood (2010)
Recombinant Interleukin-11 (rhIL-11) in Women with Refractory Menorrhagia and Von Willebrand Disease.
Authors: Rachel C. Jankowitz, Margaret V. Ragni, Holly L. Chapman, Elizabeth P. Merricks, Mark T. Kloos, Aaron M. Dillow, Helen Franck, Timothy C. Nichols
Journal: Blood (2008)
Janus kinase inhibitors display broad anti-itch properties: A possible link through the TRPV1 receptor
Authors: Tomoki Fukuyama, Joy Rachel Ganchingco, Santosh K. Mishra, Thierry Olivry, Ignacy Rzagalinski, Dietrich A. Volmer, Wolfgang Bäumer
Journal: Journal of Allergy and Clinical Immunology (2017)
Osmotic Stress–Induced Defective Glial Proteostasis Contributes to Brain Demyelination after Hyponatremia Treatment
Authors: Fabrice Gankam-Kengne, Bruno S. Couturier, Alain Soupart, Jean Pierre Brion, Guy Decaux
Journal: Journal of the American Society of Nephrology (2017)

Adequate protein folding is necessary for normal cell function and a tightly regulated process that requires proper intracellular ionic strength. In many cell types, imbalance between protein synthesis and degradation can induce endoplasmic reticulum (ER) stress, which if sustained, can in turn lead to cell death. In nematodes, osmotic stress induces massive protein aggregation coupled with unfolded protein response and ER stress. In clinical practice, patients sustaining rapid correction of chronic hyponatremia are at risk of osmotic demyelination syndrome. The intense osmotic stress sustained by brain cells is believed to be the major risk factor for demyelination resulting from astrocyte death, which leads to microglial activation, blood-brain barrier opening, and later, myelin damage. Here, using a rat model of osmotic demyelination, we showed that rapid correction of chronic hyponatremia induces severe alterations in proteostasis characterized by diffuse protein aggregation and ubiquitination. Abrupt correction of hyponatremia resulted in vigorous activation of both the unfolded protein response and ER stress accompanied by increased autophagic activity and apoptosis. Immunofluorescence revealed that most of these processes occurred in astrocytes within regions previously shown to be demyelinated in later stages of this syndrome. These results identify osmotic stress as a potent protein aggregation stimuli in mammalian brain and further suggest that osmotic demyelination might be a consequence of proteostasis failure on severe osmotic stress.
Low Level BCR-ABL Mutations Below the Detection Limit of Current Standard Screening Techniques Occur Predominantly in the CD34+ Progenitor Cell Compartment in Chronic Phase CML Patients At Diagnosis. A Substudy of the ENEST1st Trial
Authors: Jacqueline Maier, Karoline Schubert, Michael Cross, Sabine Leiblein, Kathrin Wildenberger, Frank Giles, Andreas Hochhaus, Oliver Frank, Dietger Niederwieser, Thoralf Lange
Journal: Blood (2012)
Sentinel node (SN) biopsy in patients with vulvar cancer: A Gynecologic Oncology Group (GOG) study
Authors: C. F. Levenback, C. Tian, R. L. Coleman, M. A. Gold, J. M. Fowler, P. L. Judson
Journal: Journal of Clinical Oncology (2009)

5505 Background: Vulvar cancer is a good target for SN strategy because lymphatic drainage is predictable and the morbidity of regional lymphadenectomy is significant. GOG 173 is a validation study of SN biopsy in a multi-institutional setting. Methods: Eligible patients have squamous carcinoma, nonsuspicious lymph nodes and tumor diameter between 2 cm and 6 cm. No surgeon skill verification was required. Use of radiocolloid for SN identification was an optional adjunct to blue dye until 2001 when it became mandatory. All patients underwent completion inguinal femoral lymphadenectomy. The study goal is to enroll 120 patients with nodal metastases to validate the sensitivity of SN &gt; 88% (which would lead to a false negative predictive rate of &lt;5% assuming the node metastases rate is ≤30%). Results: The study was opened in 12/1999 with 510 patients enrolled from 47 institutions (median = 5; range: 1–78 and 25 th -75 th percent: 3–14) as of 12/2008. 445 patients have data review completed. Of 403 evaluable patients, the median age was 66.9 years and 92.8% were white. 109 patients (27.1%) had lateralized lesions and unilateral groin dissections and 294 (72.9%) had midline involvement and bilateral dissections, resulting in 697 groins evaluated. SN was successfully identified in 78.8% (67/85) of patients using blue dye only and in 96.2% (306/318) using combination of radiolocalization and blue dye. For 294 patients with midline lesion treated by bilateral dissection, 159 (54.1%) had SN identified on both sides,114 (38.8%) on one side, and 21 (7.1%) not identified on either side. SN identification was successful in 373 (92.6%) patients. Nodal metastases were identified in 117 patients (31.4%). Conclusions: The combination of blue dye and radiocolloid appear superior to blue dye alone. Confirmed results for the entire cohort will be reported. No significant financial relationships to disclose.
A Dose Escalation Study of the Pharmacokinetics, Safety &amp; Efficacy of Deferitrin, an Oral Iron Chelator in Beta Thalassaemia Patients.
Authors: R. Galanello, G. Forni, A. Jones, A. Kelly, A. Willemsen, X. He, A. Johnston, D. Fuller, J. Donovan, Antonio Piga
Journal: Blood (2007)
Human Autologous Tumor-Specific T-Cell Responses Induced by Liposome Encapsulated Lymphoma Membrane Proteins.
Authors: Sattva S. Neelapu, Barry L. Gause, Linda Harvey, Andrea R. Frye, Jessie Horton, Richard J. Robb, Mircea C. Popescu, Larry W. Kwak
Journal: Blood (2004)
Incidence and Clinical Outcome of Intestinal Thrombotic MicroAngiopathy (TMA) in Patients Suspected to Clinical Graft Versus Host Disease (GVHD).
Authors: Gyeongsin Park, Yeonsook Moon, Ki-Seong Eom, Kyungji Lee, Youn-Soo Lee, Yoo-Jin Kim, Yonggoo Kim, Bin Cho, Seok-Goo Cho, Chang-Suk Kang, Kyo-Young Lee
Journal: Blood (2007)
Molecular Response with Nilotinib in Patients with Philadelphia Negative (Ph-) Chronic Myeloid Leukemia in Chronic Phase (CML-CP): ENEST1st Sub-Analysis
Authors: Andreas Hochhaus, Francois-Xavier Mahon, Philipp le Coutre, Daniel Coriu, Ljubomir Petrov, Gert J. Ossenkoppele, Nicholas C.P. Cross, Martin C. Müller, Delphine Rea, Juan Luis Steegmann, Fausto Castagnetti, Andrzej Hellmann, Gianantonio Rosti, Norbert Gattermann, Maria Liz Paciello Coronel, Jose Valentin Garcia Gutierrez, Viviana Tubazio, Angela Pellegrino, Luca Dezzani, Francis J. Giles
Journal: Blood (2015)
Phase III Trial of All-Trans Retinoic Acid (ATRA) vs Daunorubicin (D) and Cytosine Arabinoside (A) as Induction Therapy and ATRA vs Observation as Maintenance Therapy for Children with Newly Diagnosed Acute Promyelocytic Leukemia (APL).
Authors: John Gregory, Haesook Kim, Todd Alonzo, Rob Gerbing, Angela Ogden, William Woods, Howard Weinstein, Lois Shepherd, Charles Schiffer, Frederick Appelbaum, Cheryl Willman, Peter Wiernik, Jacob Rowe, Martin Tallman, James Feusner
Journal: Blood (2005)
Carbon Monoxide-Releasing Molecule-Derived CO Regulates Tissue Factor, Plasminogen Activator Inhibitor Type 1, and Thrombomodulin Production by Human Endothelial Cells.
Authors: Keiko Maruyama, Eriko Morishita, Shigeki Ohtake, Akihiro Yachie, Shinji Nakao
Journal: Blood (2010)
Long-Term Outcome of Allogeneic Stem Cell Transplantation in Patients with Combined Paroxysmal Nocturnal Hemoglobinuria and Aplastic Anemia (AA/PNH syndrome)
Authors: Sung-Eun Lee, Young-Woo Jeon, Jae-Ho Yoon, Seung-Hwan Shin, Seung-Ah Yahng, Byung Sik Cho, Ki-Sung Eom, Yoo-Jin Kim, Seok Lee, Chang-Ki Min, Hee-Je Kim, Seok-Goo Cho, Dong-Wook Kim, Woo-Sung Min, Jong-Wook Lee
Journal: Blood (2014)
Upregulation of c-Jun Induces Cell Death Via Caspase-Triggered c-Abl Cleavage in Human Multiple Myeloma.
Authors: Klaus Podar, Marc S. Raab, Giovanni Tonon, Martin Sattler, Daniela Barila, Yu-Tzu Tai, Hiroshi Yasui, Noopur Raje, Ronald A. Depinho, Teru Hideshima, Dharminder Chauhan, Kenneth C. Anderson
Journal: Blood (2006)
Semaphorin-4D and Plexin-B1 Are Elevated in Multiple Myeloma Microenvironment and Possibly Contribute in the Development of Lytic Bone Disease
Authors: Evangelos Terpos, Efstathios Kastritis, Tina Bagratuni, Dimitrios Christoulas, Athanasios Papatheodorou, Nikolaos Kanellias, Maria Gkotzamanidou, Evangelos Eleutherakis-Papaiakovou, Maria Gavriatopoulou, Meletios A Dimopoulos
Journal: Blood (2012)
Variables Predicting for Poor Mobilization of Peripheral Blood Stem Cells (PBSC) in Newly Diagnosed Myeloma Patients, Treated on TT-2 Protocol.
Authors: Frederica Cavallo, Vanessa Bolejak, Michele Cottler-Fox, Antje Hoering, Frits van Rhee, Maurizio Zangari, Guido Tricot
Journal: Blood (2005)
HIF 1 Alpha: A Suitable Target for Multiple Myeloma
Authors: Giulia Perrone, Enrica Borsi, Carolina Terragna, Sandra Durante, Marina Martello, Michela Aluigi, Manuela Mancini, Elena Zamagni, Paola Tacchetti, Annamaria Brioli, Lucia Pantani, Beatrice Anna Zannetti, Giovanni Martinelli, Maria Alessandra Santucci, Michele Baccarani, Michele Cavo
Journal: Blood (2011)
The Gold Compound Auranofin Induces Oxidative Stress and Apoptosis in Primary CLL Cells Independent of Classic Prognostic Markers and the Protective Effect of the Tissue Microenvironment
Authors: Nakhle Saba, Min Shen, Mondana Ghias, Mohammed Farooqui, Christopher Austin, Kevin Schorno, Scott Weir, Kapil Bhalla, Adrian Wiestner
Journal: Blood (2012)
Peripheral Blood Cytogenetic Studies in Hematological Neoplasms: Predictors of Obtaining Metaphases for Analysis.
Authors: Kebede Hussein, Rhett P. Ketterling, Gordon W. Dewald, Rachael L. Hulshizer, Daniel G. Kuffel, Anne E. Wiktor, Daniel L. Van Dyke, Ayalew Tefferi
Journal: Blood (2007)