tbuckley/cabot-search huggingface dataset:
Risk of schizophrenia in character disordered patients
Authors: W S Fenton, T H McGlashan
Journal: American Journal of Psychiatry (1989)

Inpatients from the Chestnut Lodge follow-up study diagnosed with character disorder were studied to predict future schizophrenic decompensation. Individually, three DSM-III criteria for schizotypal personality disorder predicted schizophrenia at long-term follow-up: magical thinking, suspiciousness or paranoid ideation, and social isolation. Additionally, lower IQ, poorer premorbid quality of work, and transient delusional experiences were predictive. No borderline personality disorder criterion was predictive. This suggests that schizotypal but not borderline personality disorder belongs in the schizophrenic spectrum. Within schizotypal personality disorder, criteria from both familial and clinical traditions appear to be dimensions of vulnerability to psychosis.
Failure to enact assisted suicide law leaves Canada’s doctors in limbo
Authors: Barbara Kermode-Scott
Journal: BMJ (2016)

Canada’s doctors, medical organisations, healthcare system, and patients have been left in legal limbo after the government missed the 6 June deadline to pass new laws legalising doctor assisted suicide.

The Supreme Court set the June deadline for the new proposed law, called Bill C-14, last February.1 2 The law has been passed in Canada’s House of Commons but remains under scrutiny and debate in the upper house, the Senate.

Since 7 June the criminal code prohibiting physician assisted dying has been lifted, but because federal legislation has not been enacted doctors, pharmacists, and nurses are unsure whether …
ARTERIOVENOUS PULMONARY FISTULA
Authors: M A LASSRICH,  VON BERNUTH, E W KECK
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Glutamine Metabolism of Chick-Heart Tissue, Rat-Heart Tissue, and Human Hypertrophic Cervical Tissue Cultivated in Synthetic Media
Authors: B. P. Gothoskar, P. N. Raina, S. S. Tate, C. V. Ramakrishnan
Journal: JNCI Journal of the National Cancer Institute (1960)

Chick-heart tissue explants differ from those of rat-heart tissue and human hypertrophic cervical tissue in that they do not require glutamine for growth in a synthetic medium and they possess the enzyme glutamine synthetase, which effects the synthesis of glutamine from glutamic acid.
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Authors: Valentina Iotchkova, Jie Huang, John A Morris, Deepti Jain, Caterina Barbieri, Klaudia Walter, Josine L Min, Lu Chen, William Astle, Massimilian Cocca, Patrick Deelen, Heather Elding, Aliki-Eleni Farmaki, Christopher S Franklin, Mattias Franberg, Tom R Gaunt, Albert Hofman, Tao Jiang, Marcus E Kleber, Genevieve Lachance, Jian'an Luan, Giovanni Malerba, Angela Matchan, Daniel Mead, Yasin Memari, Ioanna Ntalla, Kalliope Panoutsopoulou, Raha Pazoki, John R B Perry, Fernando Rivadeneira, Maria Sabater-Lleal, Bengt Sennblad, So-Youn Shin, Lorraine Southam, Michela Traglia, Freerk van Dijk, Elisabeth M van Leeuwen, Gianluigi Zaza, Weihua Zhang, Najaf Amin, Adam Butterworth, John C Chambers, George Dedoussis, Abbas Dehghan, Oscar H Franco, Lude Franke, Mattia Frontini, Giovanni Gambaro, Paolo Gasparini, Anders Hamsten, Aaron Issacs, Jaspal S Kooner, Charles Kooperberg, Claudia Langenberg, Winfried Marz, Robert A Scott, Morris A Swertz, Daniela Toniolo, Andre G Uitterlinden, Cornelia M van Duijn, Hugh Watkins, Eleftheria Zeggini, Mathew T Maurano, Nicholas J Timpson, Alexander P Reiner, Paul L Auer, Nicole Soranzo
Journal: Nature Genetics (2016)
Effects of Age, Sex, Body Weight, and Quantity of Alcohol Consumption on Occurrence and Severity of Alcoholic Hepatitis
Authors: Suthat Liangpunsakul, Puneet Puri, Vijay H. Shah, Patrick Kamath, Arun Sanyal, Thomas Urban, Xiaowei Ren, Barry Katz, Svetlana Radaeva, Naga Chalasani, David W. Crabb, David Crabb, Naga Chalasani, Suthat Liangpunsakul, Barry Katz, Spencer Lourens, Andy Borst, Ryan Cook, Andy Qigui Yu, David Nelson, Romil Saxena, Sherrie Cummings, Megan Comerford, Lakye Edwards, Vijay Shah, Gregory Gores, Patrick Kamath, Vikas Verma, Sarah Wilder, Amy Olofson, Amanda Schimek, Arun Sanyal, Puneet Puri, Susan Walker, Svetlana Raedeva
Journal: Clinical Gastroenterology and Hepatology (2016)
GC-16HYPERSENSITIVITY OF INTRACRANIAL GERMINOMAS FOR LOW-DOSE RADIATION: RELATIONSHIP BETWEEN DIAGNOSTIC RADIATION DOSE AND VOLUMETRIC CHANGES BEFORE CHEMORADIOTHERAPY
Authors: Naoki Kagawa, Ryuichi Hirayama, Yasunori Fujimoto, Yasuyoshi Chiba, Chisato Yokota, Shogo Fukuya, Daisuke Eino, Koji Takano, Manabu Kinoshita, Naoya Hashimoto, Toshiki Yoshimine
Journal: Neuro-Oncology (2016)
Engagement, Retention, and Progression to Type 2 Diabetes: A Retrospective Analysis of the Cluster-Randomised "Let's Prevent Diabetes" Trial
Authors: Laura J. Gray, Thomas Yates, Jacqui Troughton, Kamlesh Khunti, Melanie J. Davies
Journal: PLoS Medicine (2016)

Background Prevention of type 2 diabetes mellitus (T2DM) is a global priority. Let's Prevent Diabetes is a group-based diabetes prevention programme; it was evaluated in a cluster-randomised trial, in which the primary analysis showed a reduction in T2DM (hazard ratio [HR] 0.74, 95% CI 0.48–1.14, p = 0.18). We examined the association of engagement and retention with the Let's Prevent Diabetes prevention programme and T2DM incidence. Methods and Findings We used data from a completed cluster-randomised controlled trial including 43 general practices randomised to receive either standard care or a 6-h group structured education programme with an annual refresher course for 2 y. The primary outcome was progression to T2DM at 3 y. The characteristics of those who attended the initial education session (engagers) versus nonengagers and those who attended all sessions (retainers) versus nonretainers were compared. Risk reduction of progression to T2DM by level of attendance was compared to standard care. Eight hundred and eighty participants were recruited, with 447 to the intervention arm, of which 346 (77.4%) were engagers and 130 (29.1%) were retainers. Retainers and engagers were more likely to be older, leaner, and nonsmokers than nonretainers/nonengagers. Engagers were also more likely to be male and be from less socioeconomically deprived areas than nonengagers. Participants who attended the initial session and at least one refresher session were less likely to develop T2DM compared to those in the control arm (30 people of 248 versus 67 people of 433, HR 0.38 [95% CI 0.24–0.62]). Participants who were retained in the programme were also less likely to develop T2DM compared to those in the control arm (7 people of 130 versus 67 people of 433, HR 0.12 [95% CI 0.05–0.28]). Being retained in the programme was also associated with improvements in glucose, glycated haemoglobin (HbA1c), weight, waist circumference, anxiety, quality of life, and daily step count. Given that the data used are from a clinical trial, those taking part might reflect a more motivated sample than the population, which should be taken into account when interpreting the results. Conclusions This study suggests that being retained/engaged in a relatively low-resource, pragmatic diabetes prevention programme for those at high risk is associated with reductions in the progression to T2DM in comparison to those who receive standard care. Nonengagers and nonretainers share similar high-risk traits. Service providers of programmes should focus on reaching these hard-to-reach groups. Trial Registration ClinicalTrials.gov ISRCTN80605705
Attitude change concerning right to refuse treatment: the impact of experience
Authors: R L Binder, D E McNiel, P S Fishman
Journal: American Journal of Psychiatry (1985)

Forty-three medical students completed questionnaires about their attitudes toward the right to refuse treatment at the beginning and end of their psychiatric clerkship, during which time their clinical experience included exposure to involuntary psychiatric treatment. The students had a more favorable view of involuntary treatment after the clerkship; the change in attitudes was statistically significant. The authors hypothesize that the medical students' increased willingness to use seclusion and involuntary neuroleptic medication was due to exposure to agitated violent patients as well as experience with the beneficial effects of neuroleptic medication.
HG-83STABILITY OF PATIENT-DERIVED IN VITRO CULTURES OF STEM-LIKE CELLS FROM HIGH-GRADE PAEDIATRIC BRAIN TUMOURS
Authors: Susanna Larsson, Anna Danielsson, Anna Wenger, Magnus Tisell, Magnus Sabel, Birgitta Lannering, Elisabeth Schepke, Helena Carén
Journal: Neuro-Oncology (2016)
Clinical characteristics and outcome of ovarian, fallopian tube and peritoneal-like cancer in cancer of unknown primary
Authors: Takahiro Ebata, Makoto Kodaira, Tatsunori Shimoi, Jun Hashimoto, Harukaze Yamamoto, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara, Kenji Tamura
Journal: Annals of Oncology (2015)
Brain tumor chemotherapy trials: slow start, but quickly gaining.
Authors: H A Fine
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.10.2003 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7931468 Brain tumor chemotherapy trials: slow start, but quickly gaining. H A FinexH A FineSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.10.2003 PDF "Brain tumor chemotherapy trials: slow start, but quickly gaining.." Journal of Clinical Oncology, 12(10), pp. 2003–2004© 1994 by American Society of Clinical Oncology
Mammary Cancer Stages in BALB/cV Mice: Mouse Mammary Tumor Virus Expression and Virus-Host Interactions&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: B L Slagle, D Medina, J S Butel
Journal: JNCI Journal of the National Cancer Institute (1987)

A unique subline of BALB/c mice, designated "BALB/cV," exhibits an intermediate mammary tumor incidence (47%) and harbors a distinct milk-transmitted mouse mammary tumor virus (MMTV). Virus expression and virus-host interactions were examined during the different stages of mammary tumorigenesis (normal, preneoplastic, and neoplastic) in the BALB/cV system. Protein immunoblot analyses established the presence of correctly processed (BALB/cV)MMTV structural proteins in all types of BALB/cV mammary tissues. Competition enzyme-linked immunosorbent assays demonstrated that cells from each biologic phenotype were capable of supporting high levels of (BALB/cV)MMTV protein expression. However, mammary epithelial cells that spontaneously underwent the inappropriate pathway of squamous metaplasia did not contain detectable levels of (BALB/cV)MMTV structural proteins. Iodination experiments revealed the presence of a 68K env-related protein on the surface of BALB/cV mammary cells. Nevertheless, sera from 40 mice bearing BALB/cV-positive mammary tissues did not contain detectable levels of anti-env antibodies. Metabolic labeling experiments showed that the half-life of transformation-related, host cell protein p53 (approximately equal to 60 min) in the distinct BALB/cV mammary cell populations was similar to that reported for normal mouse 3T3 cells. It appears that p53 is not stabilized by protein interactions involving any MMTV-encoded or MMTV-induced protein in mammary tumor cells. These characteristics of the BALB/cV system are compatible with the hypothesis that MMTV is only one of two or more cooperating factors required to mediate complete mammary transformation.
Urinary catecholamine metabolites in hyperkinetic boys treated with d- amphetamine
Authors: W O Shekim, H Dekirmenjian, J L Chapel
Journal: American Journal of Psychiatry (1977)

The authors studied the excretion of 3-methoxy-4-hydroxyphenyl glycol (MHPG), normetanephrine (NM), metanephrine, and homovanillic acid in 7 hyperactive and 12 control children. MHPG was lower but NM was significantly higher in hyperactive children than in controls. Administration of d-amphetamine for 2 weeks depressed the levels of MHPG, NM, and metanephrine. The authors suggest a decreased central norepinephrine activity, which may be secondary to the interruption of norepinephrine fibers in the medial forebrain bundle.
Differences In Community and Academic Practice Patterns For Newly Diagnosed Myelodysplastic Syndromes (MDS) Patients In Minnesota: A Population Based Study
Authors: Daniel Pease, Julie A Ross, Phuong L. Nguyen, Betsy Hirsch, Adina Cioc, Angela R. Smith, Michelle A. Roesler, Rachel K. Fonstad, Erica D. Warlick
Journal: Blood (2013)
Magnetic resonance spectroscopy in psychiatry: potential, pitfalls, and promise [published erratum appears in Am J Psychiatry 1992 Mar;149(3):431]
Authors: M S Keshavan, S Kapur, J W Pettegrew
Journal: American Journal of Psychiatry (1991)

Magnetic resonance spectroscopy (MRS) is a novel noninvasive approach to measuring important metabolites in living tissue. Its application to psychiatry is just beginning. In vivo MRS with 31P provides important information on brain phospholipid metabolism and energy production. In vivo 13C and 1H MRS can reveal information about carbohydrate, protein, and amino acid metabolism. In vivo 7Li and 19F MRS can be used to study the pharmacology of lithium and fluorinated psychopharmacological agents. MRS with 23Na can yield information about electrolyte balance. The limitations of in vivo MRS include poor sensitivity, poor resolution, and the fact that only highly mobile atomic nuclei can be detected. Future clinical application of MRS will benefit from improvements in the technology of localization, use of spectroscopy contrast agents, stronger magnets, and the merging of MRS and imaging technology.
Induction With Carbon Tetrachloride of Liver-Cell Carcinomas in Hamsters&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Giuseppe Della Porta, Benedetto Terracini, Philippe Shubik
Journal: JNCI Journal of the National Cancer Institute (1961)

Carbon tetrachloride was administered by stomach tube to 10 female and 10 male Syrian golden hamsters, in weekly doses of 6.25 to 12.5 µl for 30 weeks. The livers of the animals dying during or after the period of treatment showed postnecrotic cirrhosis with regenerative hyperplastic nodules. All the animals, 5 females and 5 males, dying or killed 13 to 25 weeks after the end of the treatment, had 1 or more liver-cell carcinomas. No cholangiomatous tumors were observed. The induction, with N-2-fluorenylacetamide, of only cholangiomatous tumors and, with carbon tetrachloride, of only liver-cell tumors is discussed.
CR-08RETROSPECTIVE AQNALYSIS OF PAEDIATRIC CRANIOPHARYNGIOMA: A SINGLE INSTITUTION EXPERIENCE
Authors: Asha Arjunan, Prasannan Anjumol, Ratheesan Kuttan, Kusumakumary Parukuttyamma, Priyakumari Thankamony, Beela Sarah Mathew, Jiji Valsalamony, Anitha Mathews, Aleyamma Mathew, Jagathnath Krishna
Journal: Neuro-Oncology (2016)
Abnormal expression of epidermal growth factor and sulfated glycoprotein SGP-2 messenger RNA in a rat model of autosomal dominant polycystic kidney disease.
Authors: B D Cowley, J C Rupp
Journal: Journal of the American Society of Nephrology (1995)

Journal of the American Society of Nephrology : JASN 6(6):p 1679-1681, December 1995. | DOI: 10.1681/ASN.V661679
Munchausen syndrome, depression, and the dexamethasone suppression test
Authors: D. L. Evans, J. K. Hsiao, Charles Nemeroff
Journal: American Journal of Psychiatry (1984)

The authors describe two patients with Munchausen syndrome who met DSM-III criteria for major depression. Both patients exhibited evidence of nonsuppression of serum cortisol by dexamethasone. Although many patients with Munchausen syndrome have been reported to be depressed, only a few have received a diagnosis of major depression. Because the physical and psychiatric symptoms of the Munchausen patient are so complex, clinical assessment may stop at a diagnosis of Munchausen syndrome, and major depression may be overlooked. A diagnosis of major depression should be considered in the evaluation of these patients; the dexamethasone suppression test may enhance clinical assessment.
Abstract 17015: Increased Protein O-GlcNAcylation Inhibits TNF-α-Induced NFkB Signaling in Rat Aortic Smooth Muscle Cells
Authors: Dongqi Xing, Kaizheng Gong, Wenguang Feng, Susan E Nozell, Yiu-Fai Chen, John C Chatham, Suzanne Oparil
Journal: Circulation (2010)

We have previously shown that acutely augmenting O-linked-N-acetylglucosamine (O-GlcNAc) protein modification with glucosamine (GlcN) or O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylc...
Smoking Habits of Men and Women
Authors: E C HAMMOND, L GARFINKEL
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Smoking Habits of Men and Women Get access E. Cuyler Hammond, Sc.D., E. Cuyler Hammond, Sc.D. Statistical Research Section, American Cancer Society, Inc., New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar Lawrence Garfinkel, M.A. Lawrence Garfinkel, M.A. Statistical Research Section, American Cancer Society, Inc., New York, New York Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 27, Issue 2, August 1961, Pages 419–442, https://doi.org/10.1093/jnci/27.2.419 Published: 01 August 1961 Article history Received: 27 March 1961 Published: 01 August 1961
Marketing and the Most Trusted Profession: The Invisible Interactions Between Registered Nurses and Industry
Authors: Quinn Grundy, Lisa A. Bero, Ruth E. Malone
Journal: Annals of Internal Medicine (2016)

The mainstay for addressing conflicts of interest in health care is disclosure of personal financial ties to industry. However, this approach fails to capture the complexity of industry interactions that are built into clinical practice. Further, the policy climate focuses on physicians and traditional pharmaceutical marketing.To describe industry activities targeted at registered nurses.Qualitative, ethnographic study conducted from January 2012 to October 2014.Four acute care hospitals in a western U.S. city.A purposive sample of 72 participants with direct experience with industry, including staff nurses, administrators, and industry and supply chain professionals.Fieldwork, including observations (102 hours), semistructured in-depth interviews (n = 51), focus groups (n = 4), and documents analysis.Nurses' reported financial relationships with industry were similar to those reported by prescribers. However, nurses reported that their most significant interactions with industry occurred in daily practice. The current policy environment rendered these interactions invisible, leaving nurses with little guidance to ensure that the boundary between service and sales remained intact.This study could not determine the frequency or prevalence of nurse-industry interactions. The sample is not representative.Nurse-industry interactions may be common and influential, but they remain invisible in the current policy climate. Although some aspects of these interactions may be beneficial, others may pose financial risks to hospitals or safety risks to patients. Disclosure strategies alone do not provide health professionals with adequate support to manage day-to-day interactions. Management of industry interactions must include guidance for nurses.Agency for Healthcare Research and Quality; Canadian Institutes of Health Research; and University of California, San Francisco.
Ultrasound vs Angiography for Drug-Eluting Stent Implantation—Reply
Authors: Sung-Jin Hong, Byeong-Keuk Kim, Myeong-Ki Hong
Journal: JAMA (2016)

In comparing the IVUS-guided with the angiography-guided strategy for drug-eluting stent optimization, different end points and methods of vessel diameter measurement were used, as noted by Dr Hoffer, due to the intrinsic difficulty in defining common optimization criteria for both groups. We think these differences are unlikely to explain the results. Previous studies, such as the Angiography Vs IVUS Optimization (AVIO) trial1 and a meta-analysis,2 also reported larger postintervention minimal lumen diameter and lesser residual stenosis with IVUS-guided drug-eluting stent implantation. However, in the AVIO trial, the greater minimal lumen diameter in the IVUS-guided group failed to lead to better clinical outcomes, unlike in our IVUS-XPL trial.
Prevalence of tardive dyskinesia, tardive dystonia, and respiratory dyskinesia among Chinese psychiatric patients in Hong Kong
Authors: H Chiu, P Shum, J Lau, L Lam, S Lee
Journal: American Journal of Psychiatry (1992)

Only scanty information on the prevalence of tardive dyskinesia in Chinese patients has been available. This study was undertaken to examine the prevalence of tardive dyskinesia, tardive dystonia, and respiratory dyskinesia in Chinese psychiatric patients in Hong Kong.All inpatients of a mental hospital in Hong Kong, except those in the admission and children's wards, were surveyed with the Abnormal Involuntary Movement Scale, and standard research criteria were used to establish the diagnosis of tardive dyskinesia. In addition, patients were screened for tardive dystonia, according to published criteria, and for respiratory dyskinesia by physical examination and laboratory tests.Among the 917 patients surveyed, the prevalence rates were 9.3% for tardive dyskinesia, 0.4% for tardive dystonia, and 1.2% for respiratory dyskinesia. With multivariate analysis, greater age and a lower current dose of antipsychotic, but not the presence of mood disorder, were factors found to be significantly associated with tardive dyskinesia.The prevalence rates were much lower than those found in Western studies. This may indicate that there is an ethnic difference in the prevalence of these conditions. Prospective cross-cultural studies are necessary to explore this possibility.
Preventing Cancer
Authors: Janet M. Torpy
Journal: JAMA (2004)

Preventing Cancer Research studies have shown that some types of cancer are linked to an individual' s genetics (traits inherited from biological parents), lifestyle, and environmental exposures, although causes for a large proportion of cancers remain unknown.Some risk factors for cancer can be modified (see below).Other factors, such as family history, cannot be altered.However, finding out about family history and genetic risks for cancer can help with early detection and better treatment.The May 26, 2004, issue of JAMA includes several articles about cancer.
GC-05MANAGEMENT OF PRIMARY INTRASELLAR/CAVERNOUS SINUS PURE EMBRYONAL CARCINOMA IN THE SETTING OF DOWN SYNDROME
Authors: Violeta Salceda, Mohamed S. AbdelBaki, Diana S. Osorio, Suzanne Conley, Daniel R. Boue', Christopher R. Pierson, Fahd Al Sufiani, Nicholas Zumberge, Jeffrey Leonard, Jonathan L. Finlay
Journal: Neuro-Oncology (2016)