tbuckley/cabot-search huggingface dataset:
AB0820 Physical disability in mixed connective tissue disease
Authors: M. Olesinska, Z. Czuszynska, A. Felis-Giemza, K. Walkiewicz-Pielaszek, A. Paradowska-Gorycka, L. Rutkowska-Sak, I. Szczygielska, E. Wiesik-Szewczyk, Z. Zdrojewski
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Diminished physical disability is cause of morbidity in rheumatic diseases. It is well recognized problem in RA, however not yet systematically assessed in MCTD. <h3>Objectives</h3> To evaluate physical disability and its connections with clinical variables in patients with MCTD. <h3>Methods</h3> The wide range of clinical assessment of 69 MCTD patients (pts) was performed. Diagnosis was made based on Kasukawa criteria. Evaluation of physical disability was measured by HAQ-DI. Its correlations with demographic and clinical variables (clinical and serological features, Body Mass Index (BMI), treatment, disease activity, disease damage) by Spearman's rank correlation were analyzed. Disease activity was assessed independently at the same time by patient (VASPtA) and physician (VASdrA) with 100 mm visual analogue scale. The same method was used to assess disease damage: VASptD and VASdrD, respectively as well objective method Damage Index (DI) was prepared for MCTD (based on SLICC/ACR DI). Study was accepted by Local Ethics Committee. <h3>Results</h3> Median of MCTD pts age was 45 years (16 - 66), median of disease duration: 117,8 months (10-420). Median of HAQ-DI was 1.4 (min 0-max 2.25). No limitation of physical function (HAQ-DI=0) reported 17 pts (25%), mild to medium limitation (HAQ-DI: 0.1-1.0) – 41 pts (59,4%) and medium to severe limitation (HAQ-DI &gt;1,1) – 11 pts (15,9%). HAQ-DI correlated well with disease activity and damage assessed by patient: VASptA: R=0,524; p&lt;0,001; VASptD: R=0,527; p&lt;0,001 and disease damage by DI: R=0,400; p&lt;0,001. Weak correlation HAQ-DI with doctor's assessment was observed: VASdrA: R=0,243; p=0,045, VASdrD: R=0,284; p=0,019. Among analyzed clinical data statistically significant correlations were found for BMI (R=0,262; P=0,03), patient age (R=0,259; P=0,033). <h3>Conclusions</h3> Our data suggest that the physical disability is an important factor describing health status in MCTD patients. In the study, similarly like it was proved in RA [1], correlations of disability and both disease activity and irreversible damage were observed. <h3>References</h3> Aletaha D2006; 54: 2784–92. <h3>Disclosure of Interest</h3> None Declared
Abstract 1888: Metabolomic analysis provides insights into uncoupling-induced cancer resistance in the K5-UCP3 mouse model.
Authors: Ashley Solmonson, Mignon Keaton, Sara M. Nowinski, Elizabeth Morin-Kensicki, Edward M. Mills
Journal: Cancer Research (2013)

Abstract Metabolic reprogramming is a hallmark of tumorigenesis and malignancy across a variety of cancer types. Reduced oxidative phosphorylation and increased ATP synthesis by glycolytic upregulation is thought to provide both the energy and metabolic precursors necessary to meet the increased biosynthetic and energetic demands associated with malignancy. We hypothesized that since uncoupling protein 3 (UCP3) dissipates the mitochondrial electrochemical proton gradient, it may lead to the consumption or depletion of biosynthetic substrates necessary for carcinogenesis. In support, previous studies have shown that mice expressing a keratin 5-UCP3 transgene are completely resistant to chemically- and Ras-induced skin carcinogenesis, however the metabolic consequences of UCP3 overexpression in relation to cancer resistance are unclear. To examine the metabolic changes associated with UCP3 expression and this profound skin cancer resistance, we performed metabolomic analysis of more than 350 metabolites in epidermis from K5-UCP3 and wild type FVB/N littermate mice. Results of this analysis show significant UCP3-dependent changes in metabolites indicative of increased energy harvesting via glycolysis, beta-oxidation and branched chain amino acid metabolism. Consistent with decreased energy reserve, K5-UCP3 epidermis exhibits increased uncoupled respiration, decreased ATP and increased AMP levels, which correspond to increased AMP Kinase (AMPK) activation (Thr172 phosphorylation). Taken together, these data suggest that uncoupling proteins might function to oppose the metabolic demands of tumorigenesis and suggest that targeting mitochondrial uncoupling may be a novel and effective strategy in cancer prevention and treatment. Citation Format: Ashley Solmonson, Mignon Keaton, Sara M. Nowinski, Elizabeth Morin-Kensicki, Edward M. Mills. Metabolomic analysis provides insights into uncoupling-induced cancer resistance in the K5-UCP3 mouse model. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1888. doi:10.1158/1538-7445.AM2013-1888
Prevalence of Stress Reaction in the Pars Interarticularis in Pediatric Patients With New-Onset Lower Back Pain
Authors: Jigang Yang, Sabah Servaes, Kevin Edwards, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2013)

Background Spondylolysis is a defect of the pars interarticularis and is most commonly encountered in the lower lumbar spine of pediatric patients. Stress reaction of the pars interarticularis was regarded as an early stage of this pathological diagnosis in which no obvious anatomical change is detected. Both SPECT with 99mTc MDP and CT of the lumbar spine have been used to evaluate the patients with low back pain. The purpose of this study was to determine the prevalence of stress reaction in pars interarticularis in pediatric patients presenting new-onset back pain using both bone SPECT and CT. Patients and Methods The records and images of 63 consecutive pediatric patients (mean age, 13.2 years) with new onset of back pain, who received both 99mTc MDP bone scintigraphy with SPECT of the lumbar spine and lumbar thin-slice CT were retrospectively analyzed. The results of bone SPECT and CT were retrospectively compared. Results Among the cohort of 63 patients who had both bone SPECT and thin-slice CT of the lumbar spine, there was a total of 56 positive SPECT results indicating stress injuries in the pars interarticularis. Spondylolysis was shown on both bone SPECT and thin-slice CT in 45 patients. In 11 patients, stress reaction was shown. In 7 patients, no abnormality was detected by either SPECT or thin-slice CT. Conclusions Our result showed that a significant portion (19.6%, 11 of 56) of the stress injuries in the pars interarticularis will be CT-negative stress reaction in pediatric patients with new-onset back pain.
Significance of Antibodies to Dietary Proteins in the Serums of Patients with Nontropical Sprue
Authors: Raymond M. Kivel, Donald H. Kearns, Daniel Liebowitz
Journal: New England Journal of Medicine (1964)

THE term non tropical sprue (celiac disease in children) defines a group of patients with intestinal malabsorption and a characteristic, if not specific, small-bowel lesion. Another important identifying feature is the distinctive sensitivity to ingested wheat and rye proteins: abstention from these gluten-containing cereals results, in most patients, in dramatic improvement in clinical status and somewhat less dramatic reversal of the mucosal abnormality. Once remission is induced challenge with gluten or more specifically the ethyl alcohol-soluble fraction of gluten, gliadin, causes recrudescence of the absorptive and morphologic abnormalities. That allergy to gliadin might account for its effects in sprue (used . . .
THE EFFECTS OF PREFRONTAL LOBOTOMY ON THE SYMPTOMATOLOGY OF SCHIZOPHRENIC PATIENTS
Authors: DAVID ROTHSCHILD, ABRAHAM KAYE
Journal: American Journal of Psychiatry (1949)

The clinical results of prefrontal lobotomy were studied in 100 cases of schizophrenia. Ten patients were much improved, 32 were improved, 42 were slightly improved, 14 were unimproved, and 2 were worse. While the figures were more favorable in cases of less than 5 years' duration, worth-while improvement was obtained with considerable frequency in patients who had been ill for periods up to, and even beyond, 20 years. In order to determine what the foregoing results mean in terms of individual mental functions, various symptoms were studied before and after lobotomy. According to these observations, lobotomy leads to amelioration of some of the secondary or less important symptoms; it renders the patients more susceptible to external stimuli, so that they are less able to isolate themselves from the environment; and it reduces certain active reactions to more passive ones, thereby making the patients more tractible. However, prefrontal lobotomy apparently fails to produce any noteworthy improvement of the psychopathologic disturbances which are most important in schizophrenic disorders. In view of these observations the opinion is expressed that the selection of schizophrenic cases for treatment by lobotomy should be confined largely to patients who have been ill for 4 or 5 years or longer.
Abstract 4158: MicroRNA-mediated regulation of Bmi1 expression in gastric and colon cancer cells.
Authors: Hidetaka Sugihara, Takatsugu Ishimoto, Masayuki Watanabe, Hideo Baba
Journal: Cancer Research (2013)

Abstract Background: MicroRNAs (miRs) target the 3’-untranslated region (3’-UTR) of mRNA and induce translational suppression or mRNA degradation. Bmi1 is a member of the polycomb-repressive complex 1 (PRC1) that has an essential role in maintaining chromatin silencing, and is involved in the self-renewal of neuronal, haematopoietic and intestinal cells through repression of the INK4A-ARF locus. The regulatory mechanism of Bmi1 in cancer cells is still unknown. The aim of this study is to clarify the miR-mediated regulatory mechanism of Bmi1 expression in gastric and colon cancer cells. Methods and Results: We searched for miRNAs that might regulate Bmi1 using miRBase and selected 64 miRNAs as a candidate. In these miRNAs, we focused miR-30e-3p that was known to be down-regulated in colon, breast and esophageal cancer cells. First, we examined the expression of miR-30e-3p in matched cancer tissue and non-tumor tissue using formalin-fixed paraffin-embedded(FFPE) samples of gastric and colon cancer. We confirmed the expression of miR-30e-3p was significantly lower in cancer tissue than in non-tumor tissue. Next, we measured the expression of miR-30e-3p and Bmi1 by real time PCR and western blotting using gastric and colon cancer cell lines. The endogenous expression of Bmi1 and miR-30e-3p showed inverse correlation in each cell lines. Then we examined the effect of overexpression or down regulation of miR-30e-3p on the expression of Bmi1. The suppression of miR-30e-3p increased Bmi1 expression, and the overexpression of miR-30e-3p decreased Bmi1 expression. Conclusion: Our current study revealed that the expression of Bmi1 was affected by miR-30e-3p in gastric and colon cancer. Mir-30e-3p may be a therapeutic target for the treatment of gastric and colon cancer. Citation Format: Hidetaka Sugihara, Takatsugu Ishimoto, Masayuki Watanabe, Hideo Baba. MicroRNA-mediated regulation of Bmi1 expression in gastric and colon cancer cells. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4158. doi:10.1158/1538-7445.AM2013-4158
Coincidental Acquisition of Growth Autonomy and Metastatic Potential During the Malignant Transformation of Factor-Dependent CCL39 Lung Fibroblasts
Authors: D. E. Chadwick, A. E. Lagarde
Journal: JNCI Journal of the National Cancer Institute (1988)

After sc implantation into BALB/c nude mice, factor-dependent and premalignant Chinese hamster lung fibroblasts (CCL39) developed into tumors that occasionally disseminated and produced pulmonary metastases. Unlike CCL39 cells that required several growth factors (insulin, alpha-thrombin, epidermal growth factor) to proliferate in culture, metastatic tumor cells divided autonomously in serum-free medium. The re-implantation of independently isolated primary tumors revealed that they comprised factor-independent clones present at a variable frequency, as well as malignant clones that disseminated to the lungs after sc or iv inoculation. The resulting metastases invariably contained cells that were able to divide in serum-free medium and that presumably represented the progeny of autonomous variants populating the primary tumors. Among ten CCL39 variants selected in vitro for reduced growth factor requirements, two were metastatic upon sc and iv inoculation. These cell lines were the only ones that replicated rapidly in the absence of growth factors. Unlike myc transfectants, CCL39 fibroblasts that were transformed with an activated Harvey ras oncogene or that were infected with polyomavirus were both metastatic and autonomous. Taken together, these observations are consistent with the notion that the metastatic potential of CCL39 tumor cells coincides with their ability to obviate growth factor requirements and thus to divide in an autonomous fashion.
Précis of<i>The evolution of human sexuality</i>
Authors: Donald Symons
Journal: Behavioral and Brain Sciences (1980)

Abstract Patterns in the data on human sexuality support the hypothesis that the bases of sexual emotions are products of natural selection. Most generally, the universal existence of laws, rules, and gossip about sex, the pervasive interest in other people's sex lives, the widespread seeking of privacy for sexual intercourse, and the secrecy that normally permeates sexual conduct imply a history of reproductive competition. More specifically, the typical differences between men and women in sexual feelings can be explained most parsimoniously as resulting from the extraordinarily different reproductive opportunities and constraints males and females normally encountered during the course of evolutionary history. Men are more likely than women to desire multiple mates; to desire a variety of sexual partners; to experience sexual jealousy of a spouse irrespective of specific circumstances; to be sexually aroused by the sight of a member of the other sex; to experience an autonomous desire for sexual intercourse; and to evaluate sexual desirability primarily on the bases of physical appearance and youth. The evolutionary causes of human sexuality have been obscured by attempts to find harmony in natural creative processes and human social life and to view sex differences as complementary. The human female's capacity for orgasm and the loss of estrus, for example, have been persistently interpreted as marriage-maintaining adaptations. Available evidence is more consistent with the view that few sex differences in sexuality are complementary, that many aspects of sexuality undermine marriage, and that sexuality is less a unifying than a divisive force in human affairs.
SP0021 Complement C5A and immune-complexes promote TNF-dependent pathologies via stimulation of the TNF-alpha convertase (TACE)
Authors: C. Blobel
Journal: Annals of the Rheumatic Diseases (2013)

Rheumatoid arthritis (RA) is triggered by inflammatory mediators such as anaphylatoxin C5a and immune-complexes, yet much remains to be learned about the underlying mechanisms. Here, we show that C5a and immune-complexes activate the principal TNFα convertase, TACE, thereby triggering release of TNFα. TACE belongs to the ADAM (a disintegrin and metalloproteinase) family of membrane-anchored metalloproteinases, which have emerged as key regulators of cell-cell interactions. Mice lacking TACE in myeloid cells are protected from inflammatory arthritis in the K/BxN serum transfer model of RA, providing the first genetic evidence for a critical role for TACE in myeloid cells in the pathogenesis of RA. These results support the notion that TACE is an attractive target for treatment of TNFα-dependent pathologies. <h3>Disclosure of Interest</h3> None Declared
SP0118 Current Strategies of Primary and Secondary Fracture Prevention
Authors: W. Lems
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> Osteoporosis, characterised by a low bone mineral density and decreased bone quality, occurs frequently in the elderly. It is estimated that due to the ageing of the population, the number of fractures may rise 30—40% in Europe in the coming 15 years. For the primary prevention of fractures (in patients without a recent fracture) it is crucial to select those patients at high risk for fractures. Apart from ageing, low body mass, familary osteoporosis, elevated fall risk, and immobility, comorbidity (including inflammatory rheumatic diseases) and comedication (among which glucocorticoids) are also important risk factors. With FRAX it might useful to calculate the 10-years major- and hipfracture risk in individual patients. Primary prevention can be limited by suboptimal selection of patients, while adherence to treatment is another serious issue. The risk of a subsequent fracture is increased after an incident fracture; unfortunately the routinely performing of investigations to underlying osteoporosis (DXA) occurs only in minority of patients. This is even more striking since effective, relatively safe, and non-expensive drugs are available. One of the most attractive options is to start with a fracture liaison service, in with all patients 50 years and over with a recent fracture will be systematically investigated for low BMD and other risk factors for future fractures, such as elevated fall risk, secondary osteoporosis and vertebral fractures. Currently a working group is formulating a combined set of EULAR-EFORT recommendations not only on the surgical treatment of fractures, but also on the diagnosis and treatment of osteoporosis in patients 50 years and over with a recent fracture. We hope that these recommendations are helpful in daily practice for orthopaedics, reumatologists and others who are trying to optimalize the care of fracture patients <h3>Disclosure of Interest</h3> W. Lems Speakers bureau: Amgen, Eli Lilly, Merck, Servier, Will Pharma, Novartis.
Primary Atypical Pneumonia Due to<i>Mycoplasma pneumoniae</i>(Eaton Agent)
Authors: Maurice A. Mufson, Vernon Sanders, Serrah G. Wood, Robert M. Chanock
Journal: New England Journal of Medicine (1963)

RECENT evidence from seroepidemiologic and volunteer studies has established Eaton agent (Mycoplasma pneumoniae∥) as the causative agent of cold agglutinin-positive primary atypical pneumonia.2 3 4 5 In the majority of untreated cases the duration of the illness is generally two or three weeks, with complete resolution of the clinical and radiographic abnormalities.6 This report describes an unusually severe case in which the patient was in the hospital for six weeks and in which a residual radiographic abnormality was present one year after the onset of illness. Diagnosis was established by isolation of M. pneumoniae and the development of a sixteenfold rise . . .
Triggering of Sudden Death from Cardiac Causes by Vigorous Exertion
Authors: Christine M. Albert, Murray A. Mittleman, Claudia U. Chae, I.-Min Lee, Charles H. Hennekens, JoAnn E. Manson
Journal: New England Journal of Medicine (2000)

Retrospective and cross-sectional data suggest that vigorous exertion can trigger cardiac arrest or sudden death and that habitual exercise may diminish this risk. However, the role of physical activity in precipitating or preventing sudden death from cardiac causes has not been assessed prospectively in a large number of subjects.
Absence of Toxicity of Avenin in Patients with Dermatitis Herpetiformis
Authors: Catherine Hardman, Lionel Fry, Arthur Tatham, Huw J.W. Thomas
Journal: New England Journal of Medicine (1999)

To the Editor: Krag et al. (Oct. 1 issue) 1 present interesting data on the use of probe-guided resection of radioactive sentinel nodes in patients with breast cancer, but they conclude that "the procedure can be technically challenging, and the success rate varies according to the surgeon."In our opinion, preoperative lymphoscintigraphy can facilitate surgical localization and excision of the sentinel node and increase the detection rate.Lymphoscintigraphy is a nuclear-medicine procedure that is easy to perform and, in conjunction with the intraoperative gamma probe, has been successfully used primarily in patients with malignant melanoma or breast cancer. 2,3The main advantage of this imaging technique is that it allows accurate preoperative localization of the sentinel node; after scintigraphic images have been obtained, a mark can be made on the skin that corresponds to the first lymph node detected by the gamma camera, thereby indicating precisely where the incision should be made.The use of the gamma probe during surgery then guides dissection, making the node biopsy easier and consistently successful.In most patients, the sentinel node is visible within 30 minutes after the injection, regardless of the size of the radiolabeled particles used, when they are injected subdermally. 4Lymphoscintigraphy is not time-consuming; anterior and lateral views, each obtained within five minutes, are sufficient to identify another 10 percent of sentinel nodes that might have not been detected with the use of a probe survey alone. 5
Case 40-1998
Authors: Mark A. Popovsky, Susan L. Saidman
Journal: New England Journal of Medicine (1998)

Presentation of CaseA 49-year-old right-handed woman was admitted to the hospital because of a hemorrhagic stroke and mutism.The patient had been well until two weeks earlier, when she began to have menorrhagia and orthostatic weakness. One day before admission, she entered another hospital, where she was found to have uterine leiomyomas. Laboratory studies were performed (Table 1 and Table 2). Two units of packed red cells were transfused, and dilation with curettage was performed. On the next day, she felt better until midday, when she suddenly had a severe headache, followed by an inability to speak, although she could understand . . .
Myotomie endoscopique pour achalasie: un geste efficace et sûr?
Authors: M Pioche, S Roman, M Ciocirlan, F Mion, T Ponchon
Journal: Endoscopy (2014)

La myotomie per orale endoscopique (POEM) est prometteuse pour la prise en charge de l'achalasie œsophagienne. Nous rapportons les résultats en termes de faisabilité, de sécurité et d'efficacité de la première étude prospective française.