tbuckley/cabot-search huggingface dataset:
AB0413 Comparison of bucillamine-induced membranous nephropathy and non drug-induced membranous nephropathy in patients with rheumatoid arthritis
Authors: N. Hayami, Y. Ubara, T. Suwabe, K. Sumida, K. Mise
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Membranous nephropathy (MN) is famous as extra articular lesion of rheumatoid arthritis (RA). Most of them are caused by Disease-modifying antirheumatic drugs (DMARDs), especially bucillamine. But MN that is not caused by drug (non drug-induced MN) can occur in patients with RA. The characteristics of non drug-induced MN and the differences with bucillamine-induced MN are unclear. <h3>Objectives</h3> To investigate differences between bucillamine-induced MN and non drug-induced MN in patients with RA. <h3>Methods</h3> 39 patients with RA who had a diagnosis of membranous nephropathy in our hospital from January 1985 to December 2009 were enrolled in this study. Membranous nephropathy was revealed by renal biopsy in all cases. They are categorized as having bucillamine-induced MN or non drug-induced MN. All patients checked creatinine and proteinuria both at baseline and at follow-up. These data and pathological findings were compared in two groups. <h3>Results</h3> Bucillamine-induced MN was 26 subjects and non drug-induced MN was 9 subjects. In Bucillamine-induced MN group and non drug-induced MN group, follow up time (6.1±4.7 vs. 6.4±4.9 years, p=0.84), creatinine at baseline (0.8±0.3 vs. 1.1±0.5 mg/dl, p=0.23), proteinuria at baseline (3.6±3.2 vs. 3.6±4.1 g/day, p=0.58) and creatinine at follow-up (0.8±0.3 vs. 1.4±0.9 mg/dl, p=0.12) did not have the difference. Proteinuria at follow-up was lower in Bucillamine-induced MN group compared to non drug-induced MN group (0.1±0.1 vs. 1.3±2.8g/day, p&lt;0.05). In bucillamine group, proteinuria disappeared in all of cases after discontinuance of medicine. In non drug-induced MN group, the course was various. In some cases of this group, proteinuria disappeared after decrease of RA activities by treatment of RA. The findings of the light microscope in two groups were not different. But in an electron microscope, the bucillamine group had little quantity of the deposit and the size was uneven. <h3>Conclusions</h3> In bucillamine group, proteinuria disappeared after discontinuance of medicine. In some cases of non drug-induced MN, proteinuria disappeared after decrease of RA activities by RA treatment, and it was possible that the control of RA activity contribute the improvement of MN in patients with RA. <h3>Disclosure of Interest</h3> None Declared
The Outbreak of West Nile Virus Infection in the New York City Area in 1999
Authors: Denis Nash, Farzad Mostashari, Annie Fine, James Miller, Daniel O'Leary, Kristy Murray, Ada Huang, Amy Rosenberg, Abby Greenberg, Margaret Sherman, Susan Wong, Grant L. Campbell, John T. Roehrig, Duane J. Gubler, Wun-Ju Shieh, Sherif Zaki, Perry Smith, Marcelle Layton
Journal: New England Journal of Medicine (2001)

In late August 1999, an unusual cluster of cases of meningoencephalitis associated with muscle weakness was reported to the New York City Department of Health. The initial epidemiologic and environmental investigations suggested an arboviral cause.
SP0038 Harnessing the Potential of the Internet: Developing a Web-Based Self-Management Program for Adolescents with Arthritis
Authors: J. N. Stinson
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> With emerging interactive and communication technologies (e-health), especially the internet, new media for the delivery of psychological interventions to help youth learn how to self-manage chronic health conditions pain. The internet has emerged as one of the top health information resources and modes of social communication for young people and continues to be increasingly integrated into the provision of health care services. Dr. Stinson will discus the development, usability testing and preliminary evaluation of a web-based self-management program for youth with JIA using a sequential phased approach. These novel e-health interventions can be a first step in a stepped approach to provide education and psychological therapies to help children and their families learn to better manage their disease and ultimately improve health-related quality of life. Finally, Dr. Stinson will outline challenges and opportunities of e-health and future directions for research. <h3>Disclosure of Interest</h3> None Declared
AB1158 Efficacy and security of anakinra treatment in patients with systemic-onset juvenil idiopathic arthritis: “Initial results from a register of two pediatric reumatologic units from spain”:
Authors: I. Calvo, I. Marvillet, B. Lόpez, A. Marco, Y. Rodriguez, R. Bou, S. Ricart, J. Calzada, V. Torrent, J. Antόn
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Interleukin-1 (Il-1) is a critical cytokine for the pathogenesis of systemic JIA. Treatment with anakinra (Il-1 receptor antagonist) has been reported to be effective in some patients with systemic-onset juvenile idiopathic arthritis (SoJIA). <h3>Objectives</h3> To examine the safety and the efficacy of anakinra treatment in a cohort of SoJIA patients regarding clinical and biological data from two reference centers. <h3>Methods</h3> We retrospectively reviewed the medical records of 50 patients with SoJIA, treated with anakinra (1-3 mg/kg/day) at the pediatric rheumatologic units of two tertiary university hospitals in Spain between 2004 and 2011. Anakinra's effects were studied on several parameters including clinical parameters (fever, rash, limited and active joints), time since symptoms started and diagnose to beginning of treatment, biological parameters (erythrocyte sedimentation rate (ESR), C-reactive protein levels (CRP), ferritin, and white blood cell count (WCC)). Resulting data were analysed to characterize therapies, clinical course and adverse events. Statistics were obtained using SPSS program. <h3>Results</h3> There were 28 (56%) boys and 22 (44%) girls. Age at diagnosis varied from 7 months to 15,8 years (median 6,6 years). Time from diagnosis to anakinra treatment varied from 0 to 118 months (median 16,43 months). Treatment duration varied from 0 to 70 months (mean 23,6 months). Statistical significance was found when comparing at 0 and 6 month of treatment with anakinra in: Fever (p&lt;0,001), rash (p&lt;0,001), ESR (p&lt;0,001), CRP (p&lt;0,001), Ferritin (p&lt;0,049), WCC (p&lt;0,001), active arthritis joint count (p&lt;0,001), limited joint count (p&lt;0,031). A significant relationship (Spearman correlation) was observed regarding the number of active and limited joints when we analysed the time passed between diagnosis and anakinra treatment onset (Table 1). Side effects at 6 months were hipertransaminasemia (1 patient), macrophage activation syndrome (1 patients), tipe I hypersensibility (2 patients). Pain at the anakinra injection site was present in 70% of the patients but in all cases, pain disappeared within 2 months. <h3>Conclusions</h3> These results show that shortening the time passed from diagnosis to anakinra treatment reduces the number of active and limited joints, since then, anakinra should be considered as a first line therapy in SoJIA patients. <h3>Disclosure of Interest</h3> None Declared
TREATMENT WITH THE V1A/V2-VASOPRESSIN RECEPTOR ANTAGONIST CONIVAPTAN INCREASES CARDIAC OUTPUT DURING EXERCISE IN PATIENTS WITH ADVANCED HEART FAILURE
Authors: Louise Balling, Jakob H. Thomsen, Emil Wolsk, Christian Hassager, Soeren Boesgaard, Steven Goldsmith, Finn Gustafsson
Journal: Journal of the American College of Cardiology (2016)
Abstract 3240: Understanding clonal complexity of a tumor xenograft model via cellular barcoding technology
Authors: Justina X. Caushi, Hyo-eun C. Bhang, Jie Li, Iris Kao, Viveksagar Krishnamurthy Radhakrishna, Vesselina G. Cooke, Joshua M. Korn, David A. Ruddy, Shailaja Kasibhatla, Frank Stegmeier
Journal: Cancer Research (2015)

Abstract Recent advances in next-generation sequencing have revealed the presence of genetic heterogeneity and clonal evolution within tumors. Intratumoral heterogeneity has been implicated in the disease progression, metastasis, therapeutic responses and development of drug resistance. Although cancer cell line xenograft models have been extensively used in cancer research to test drug efficacy, it is unknown how much clonal heterogeneity is maintained in the process of cell line xenograft establishment. In order to quantitatively assess the clonal complexity in xenograft models, here we applied a cellular barcoding technology using the HCC827 cell line. HCC827 is a non-small cell lung cancer cell line containing an exon 19 deletion which has been shown to be clinically relevant due to its initial response to EGFR inhibitors followed by resistance. This barcoding tool allowed us to label each individual cell with one unique DNA barcode via lentiviral infection and monitor the clonal heterogeneity within the implanted cell population by quantifying the number of unique barcodes. We were able to estimate the percentage of implanted clones that actually contributed to the formation of cell line xenografts. This study provides valuable insight on the clonal diversity present in xenograft models, which will further elucidate the heterogeneous nature of tumors. Citation Format: Justina X. Caushi, Hyo-eun C. Bhang, Jie Li, Iris Kao, Viveksagar Krishnamurthy Radhakrishna, Vesselina G. Cooke, Joshua M. Korn, David A. Ruddy, Shailaja Kasibhatla, Frank Stegmeier. Understanding clonal complexity of a tumor xenograft model via cellular barcoding technology. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3240. doi:10.1158/1538-7445.AM2015-3240
Clinical and Pathological Features of Ovarian Cancer in Women with Germ-Line Mutations of<i>BRCA1</i>
Authors: Stephen C. Rubin, Ivor Benjamin, Kian Behbakht, Hiroyuki Takahashi, Mark A. Morgan, Virginia A. LiVolsi, Andrew Berchuck, Michael G. Muto, Judy E. Garber, Barbara L. Weber, Henry T. Lynch, Jeff Boyd
Journal: New England Journal of Medicine (1996)

We tested the hypothesis that ovarian cancers associated with germ-line mutations of BRCA1 have distinct clinical and pathological features as compared with sporadic ovarian cancers.
AB0523 Factors Affecting the Renal Functional Reserve and the Development of Chronic Kidney Disease in Patients with Systemic Lupus Erythematosus
Authors: L. Khusnutdinova, A. Maksudova, S. Yakupova
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Renal involvement is one of the main prognostic factor of systemic lupus erythematosus (SLE) through chronic kidney disease (CKD) development. It was shown, that hyperfiltration is the one of the main insult of CKD progression and in SLE plays a part like a immune activity. Hyperfiltration may be detected by determination of decreased renal function reserve (RFR) in earliest stages of CKD; hypertension and proteinuria act together decreasing RFR. <h3>Objectives</h3> The goal of the study is evaluation of renal function reserve in patients with SLE and to study the role of hypertension and proteinuria in RFR of SLE patients <h3>Methods</h3> 30 SLE patients (3 men and 30 women) has been examined, without of CKD criteria9s. Patients were 34,3±12,8 yeas old with disease duration 77,6±75,6 month. Disease activity was determined by SLEDAI was 11,0±4,5 points. 19 patients had arterial hypertension. Renal functional reserve was evaluated in the <i>acute pharmacological</i> test with dopamine. We studied the level of creatinine in blood and in urine before and after the test and the volume of urine an hour before and after the test. Glomerular filtration rate (GFR) was also calculated. RFR was evaluated as the difference between the original and stimulated GFR and regarded as normal if it was more or equal to 15% and decreased – less than 15% and negative quantities. Comparison group included 40 healthy people matched according to age and sex. <h3>Results</h3> All healthy volunteers has had normal RFR, 41,4±25.5%. In SLE patients we found significantly decreased level RFR – 8,1±53,8%, p=0,001. Normal RFR was determined in 18 patients, in 15 SLE patients RFR was decreased (54,2±28,9 vs -37,9±28,1%). The groups were found to have significantly different level of disease activity (SLEDAI 8,69±3,24 vs 13,38±4,66), hypertension and proteinuria level has not been different (1,50±2,85 g/24h vs 1,30±1,47 g/24h). Level of RFR inversely correlate with disease activity; correlation is more significant in patients with normal RFR (p=0,001). In patients with decreased RFR hypertension level and it9s fact correlates significantly with RFR data9s. Normal RFR group showed significant correlation with proteinuria level. <h3>Conclusions</h3> In SLE patients without CKD showed high frequency of decreased RFR. Disease activity is main determinative factor of RFR level in SLE patients without CKD and preserved RFR. Arterial hypertension plays the main role in CKD progression in the case of decreased RFR. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5793
MS-21 * SUBEPENDYMOMAS DEMONSTRATE LINEAGE MARKERS SUGGESTING AN ORIGIN WITHIN MULTIPOTENTIAL PROGENITORS OF THE SUBVENTRICULAR ZONE
Authors: M. Praver, R. D'Amico, P. Canoll, J. Bruce
Journal: Neuro-Oncology (2014)

OBJECTIVE: Subependymomas are infrequent, low-grade gliomas associated with the ventricular system and the spinal cord. Little is known about the origin and natural history of these slow-growing lesions. METHODS: We identified all patients with pathologically proven subependymomas presenting to our institution between 1998 and 2013. We retrospectively reviewed clinical, radiographic, histological, and surgical outcomes data in all patients who underwent surgical resection. Immunohistochemical analyses for a number of cell lineage markers was performed. RESULTS: A total of 24 patients with pathologically proven subependymomas were identified. Of these, 7 asymptomatic lesions were discovered at autopsy and 17 symptomatic cases were treated surgically. There were 8 lateral ventricle tumors, 5 spinal tumors and 4 fourth ventricular tumors. Symptomatic intracranial lesions most commonly presented with headaches, changes in vision, and balance difficulty. Subependymomas had no distinguishing radiographic features that provided definitive pre-operative diagnosis. At last follow up, no patient treated surgically experienced recurrence, although one patient with histologically mixed subependymoma-ependymoma subsequently developed and was treated for a remote glioblastoma. Immunohistochemical analyses demonstrated mixed populations of cells that were variably positive for Olig2, NeuN, Sox2, and CD44. CONCLUSION: Subependymomas demonstrate a mixed population of cells expressing neuronal and glial lineage markers as well as putative stem cell markers, suggesting these tumors may arise from multipotential progenitors that reside in the subventricular zone. Definitive diagnosis requires surgical sampling. While the clinical course is usually benign following surgical resection, the rare association with glial malignancy and the potential for malignant progression merits further investigation.
Diagnosis of left adrenal paracoccidioidomycosis by endoscopic ultrasound fine needle aspiration
Authors: R. Colaiacovo, R. Ganc, A. Leone, M. Medeiros, L. Rossini
Journal: Endoscopy (2011)

Paracoccidioidomycosis is a systemic granulomatous disease endemic in Latin America. It is acquired through the inhalation of spores released by Paracoccidioides brasiliensis [1]. Impairment of adrenal function may be found in 15 % – 20 % of patients with paracoccidioidomycosis [1]. Although highly specific (> 85 %), serological tests may be false-negative in immunosuppressed patients [1]. Hence, detection of fungal elements is the diagnostic gold standard. A PubMed review revealed that adrenal biopsies done to diagnose paracoccidioidomycosis are mostly guided either by computed tomography or by abdominal ultrasound [2] [3]. This is the first case report of diagnosis of paracoccidioidomycosis in the left adrenal gland by endoscopic ultrasound fine needle aspiration (EUS-FNA).
OBSERVATIONS ON THE HISTOPATHOLOGY OF SCHIZOPHRENIA
Authors: N. W. WINKELMAN, M. HAROLD BOOK
Journal: American Journal of Psychiatry (1949)

1. Ten selected cases of schizophrenia from a group of 6o have been studied clinically and pathologically with special emphasis on the cortex. 2. Although the gross appearance of the brain was not at all distinctive, the microscopic picture was such as to suggest the diagnosis. 3. The main microscopic findings were: focal and general loss of nerve cells, especially in the anterior half of the brain; the presence of numerous nerve cells showing degenerative changes, such as shrinkage, vacuolization of cytoplasm, "ghost-cells," loss of polarity, and fatty infiltration. A fairly uniform hyperplasia and hypertrophy of macroglia was noted. A diffuse mild subcortical demyelinization was present. 4. There was no involvement of the mesodermal components of the brain. 5. An increasing array of evidence in many related fields is accumulating to bolster the contention that schizophrenia should be included among the "organic" psychoses.
Ultrasound-guided imaging of junctional adhesion molecule-A-targeted microbubbles identifies vulnerable plaque in rabbits
Authors: Ya-Jun Zhang, Dan-Na Bai, Jing-Xi Du, Liang Jin, Jing Ma, Jia-Lei Yang, Wen-Bin Cai, Yang Feng, Chang-Yang Xing, Li-Jun Yuan, Yun-You Duan
Journal: Biomaterials (2016)
TRPC6 G757D Loss-of-Function Mutation Associates with FSGS
Authors: Marc Riehle, Anja K. Büscher, Björn-Oliver Gohlke, Mario Kaßmann, Maria Kolatsi-Joannou, Jan H. Bräsen, Mato Nagel, Jan U. Becker, Paul Winyard, Peter F. Hoyer, Robert Preissner, Dietmar Krautwurst, Maik Gollasch, Stefanie Weber, Christian Harteneck
Journal: Journal of the American Society of Nephrology (2016)

FSGS is a CKD with heavy proteinuria that eventually progresses to ESRD. Hereditary forms of FSGS have been linked to mutations in the transient receptor potential cation channel, subfamily C, member 6 ( TRPC6 ) gene encoding a nonselective cation channel. Most of these TRPC6 mutations cause a gain-of-function phenotype, leading to calcium–triggered podocyte cell death, but the underlying molecular mechanisms are unclear. We studied the molecular effect of disease-related mutations using tridimensional in silico modeling of tetrameric TRPC6. Our results indicated that G757 is localized in a domain forming a TRPC6-TRPC6 interface and predicted that the amino acid exchange G757D causes local steric hindrance and disruption of the channel complex. Notably, functional characterization of model interface domain mutants suggested a loss-of-function phenotype. We then characterized 19 human FSGS–related TRPC6 mutations, the majority of which caused gain-of-function mutations. However, five mutations (N125S, L395A, G757D, L780P, and R895L) caused a loss-of-function phenotype. Coexpression of wild-type TRPC6 and TRPC6 G757D, mimicking heterozygosity observed in patients, revealed a dominant negative effect of TRPC6 G757D. Our comprehensive analysis of human disease–causing TRPC6 mutations reveals loss of TRPC6 function as an additional concept of hereditary FSGS and provides molecular insights into the mechanism responsible for the loss-of-function phenotype of TRPC6 G757D in humans.
Abstract 4544: Novel indolequinone inhibitors of thioredoxin reductase are active against human pancreatic cancer
Authors: Chao Yan, Biehuoy Shieh, Phillip Regan, Zhiyong Zhang, Marie Colucci, Aurélie Chilloux, Jeffery Newsome, David Siegel, Dan Chan, Christopher J. Moody, David Ross
Journal: Cancer Research (2010)

Abstract A series of indolequinones was previously developed in our lab as potential antitumor agents against pancreatic cancer. Three general classes of indolequinone consisting of 2-methyl, 2-hydroxymethyl and 2-unsubstituted derivatives with varying leaving groups at the indole 3- position exhibited marked activity against human pancreatic cancer both in vitro and in vivo. Pancreatic cancer cell lines PANC-1, MIA PaCa-2, and BxPC-3 were used to ensure effects were not cell line specific and growth inhibitory effects were measured using both the MTT and clonogenic assays. Indolequinones displayed growth inhibitory activity against pancreatic tumor cells in vitro and two specific classes of indolequinone, the 2-unsubstituted and 2-hydroxymethyl classes, were particularly active agents with IC50 values in the 20-200nM range. Indolequinones were also found to be efficient inducers of apoptosis in pancreatic cancer cell lines at concentrations which induced growth inhibition. Selected indolequinones were also screened against the NCI-60 cell line panel to reveal the pattern of activity across various tumor types and were particularly effective against colon, renal, and melanoma cancer cells. The spectrum of activity of indolequinones in the NCI-60 was similar to established inhibitors of thioredoxin reductase. Indolequinones of both the 2-hydroxymethyl and 2-unsubstituted classes were found to inhibit thioredoxin reductase in MIA PaCa-2 cellspancreatic cancer at concentrations equivalent to those inducing growth inhibitory effects. The mechanism of inhibition of thioredoxin reductase by the indolequinones was studied in detail in cell-free systems using purified enzyme and the C-terminal selenocysteine of thioredoxin reductase was found to be the primary adduction site of the indolequinones using LC-MS analysis. Inhibition of thioredoxin reductase by indolequinones in cells resulted in a change of thioredoxin redox state and activation of the P38/JNK signaling pathway which may result in downstream apoptosis. Our results demonstrate that thioredoxin reductase is a potential target of the indolequinones in pancreatic cancer cells. (Supported by CA11441). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4544.
INTERDEPENDENCE OF RIGHT VENTRICULAR SYSTOLIC FUNCTION AND LEFT VENTRICULAR FILLING AND ITS ASSOCIATION WITH OUTCOME FOR PATIENTS WITH PULMONARY HYPERTENSION
Authors: Yoshiki Motoji, Hidekazu Tanaka, Yuko Fukuda, Keiko Ryo, Hiroyuki Sano, Kumiko Dokuni, Yutaka Hatani, Hiroyuki Shimoura, Keiko Hatazawa, Hiroki Matsuzoe, Hiromi Toki, Junichi Ooka, Takuma Sawa, Yasuhide Mochizuki, Kazuhiro Tatsumi, Kensuke Matsumoto, Noriaki Emoto, Ken-ichi Hirata
Journal: Journal of the American College of Cardiology (2015)
Biweekly THP-COPBLM (pirarubicin, cyclophosphamide, vincristine, prednisone, bleomycin and procarbazine) regimen combined with granulocyte colony-stimulating factor (G-CSF) for intermediate- and high-grade non-Hodgkin's lymphoma
Authors: N Niitsu, M Umeda
Journal: Leukemia (1998)