tbuckley/cabot-search huggingface dataset:
AB0630 Therapeutic modalities and outcomes of lupus nephritis in korea: Retrospective multicenter experiences
Authors: J.-S. Lee, S.-Y. Bang, Y.M. Kang, H.A. Kim, C.-H. Suh, T.-J. Kim, Y.-W. Park, K.-H. Jung, D.-H. Yoo, S.C. Bae, H.-S. Lee
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Lupus nephritis (LN) is one of the major manifestations of systemic lupus erythematosus (SLE) which need aggressive immunosuppressive treatments. <h3>Objectives</h3> The aim of this study was to investigate which therapeutic modalities were used for LN and whether response rate between therapeutics was different or not. <h3>Methods</h3> One hundred sixth nine patients with LN on biopsy, who followed up more than at least 6 months after diagnosis, were included from multicenters in Korea between 2000 and 2010. We retrospectively analyzed the clinicopathologic data using WHO or ISN/RPS, therapeutics, and responses based on 2006 ACR remission criteria. Poor outcome was defined as chronic renal failure (GFR &lt;60 ml/min), and death. <h3>Results</h3> The mean age at the time of diagnosis of LN was 31.2 years and 41.1 months was followed. The proportion of class II, III, IV, and V was 14 (8%), 58 (34%), 63 (37%), and 34 (20%), respectively. Induction therapeutic modalities were different between classes of LN; the most common therapeutics for class IV was cyclophosphamide NIH regimen [CYC(NIH)] 50%, followed by mycophenolate mofetil (MMF) 33% and CYC Euro regimen [CYC(EUR)] 13%, in contrast to CYC(NIH) 41%, and azathioprine (AZA) 24% for class III, and cyclosporine(CS) 47%, and CYC(NIH) 21%] for class V. In addition, therapeutics for maintenance were also different between classes; MMF 42.2% and AZA 22% for class IV, AZA 43% and MMF 25% for class III, and CS 44% and MMF 20% for class V. Complete or partial response after induction therapy was achieved in 83%, 74%, and 79% of patients with class III, class IV, and class V, respectively. The response rate between induction therapeutics for LN classes was not significantly different. Poor outcome defined by chronic renal failure was observed in 4.1% (n=7) of patients, and was significantly associated with poor induction response (OR 30.1 [3.2-284.1]) and 1-year response (OR 16.0 [2.1-123.3]). <h3>Conclusions</h3> Response to current therapeutics for each class of LN was favorable, regardless of therapeutic regimens. With appropriate induction therapy according to baseline renal function and histological class, remission to induction therapy was important factor for renal survival. <h3>Disclosure of Interest</h3> None Declared
CEREBROVASCULAR EVENTS (CVE) POST TRANSCATHETER AORTIC VALVE REPLACEMENT(TAVR): A COMPREHENSIVE META-ANALYSIS AND META-REGRESSION
Authors: Navkaranbir S. Bajaj, Saurabh Gaba, Himanshu Aggarwal, Vikas Bhatia, Federico De Puy, Michael Mack, David Holmes, Oluseun Alli
Journal: Journal of the American College of Cardiology (2015)
Abstract 3017: MicroRNAs as prognostic indicators in gastric cancer
Authors: Michal Kushnir, Moshe B. Hoshen, Ofer Purim, Eti Meiri, Hila Cholakh, Naama Barabash, Yaron Goren, Gideon Marshak, Yulia Kundel, Sara Morgenstern, Marisa Halpern, Yaron Niv, Ayelet Chajut, Baruch Brenner
Journal: Cancer Research (2010)

Abstract Background: Our ability to determine the prognosis of an individual patient with gastric cancer and thereby to select patients for adjuvant therapy is still limited. Preliminary data suggest that microRNAs may have a prognostic role in this disease. We hence decided to compare the microRNA profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer and to evaluate the prognostic impact of these molecules. Patients and Methods: Eligible patients, who underwent curative gastrectomies between 1995 and 2005 and did not receive any pre- or postoperative adjuvant therapy, were identified from the database of the participating institutions. Total RNA was extracted from tumor formalin-fixed paraffin embedded (FFPE) samples using proprietary protocols that preserve the small RNA fraction. Initial profiling using microRNA microarrays identified potential microRNA biomarkers that can be used to predict recurrence of gastric cancer after resection. The expression of differential microRNAs, was verified by qRT-PCR. Results: Forty-five eligible patients had adequate tumor content and microRNA expression data and were included in the analysis. Of these, 14 (31%) experienced recurrence of disease within three years from surgery (“bad prognosis” group) and 31 (69%) did not (“good prognosis” group). Advanced pathological stage and extensive surgical procedure correlated with bad prognosis. Signal levels of three microRNAs were found to be significantly differentially expressed in tumors from patients with good prognosis vs. patients with bad prognosis. High expression of each of these microRNAs was associated with significantly poorer prognosis for both recurrence and survival. Proprietary microRNA qRT-PCR showed a high correlation to microarrays and similar separation into prognosis groups based on microRNA expression. Conclusion: We identified a set of microRNAs whose high expression was predictive of tumor recurrence and poor prognosis in patients with gastric cancer. This finding provides a basis for a novel tool for risk stratification in this disease and allows further insight into its pathogenesis. Based on these results, a validation study, on a larger and independent cohort of patients, is planned. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3017.
Itching for a Diagnosis
Authors: Libby Schaefer, Julie M. Paik, Helmut Rennke, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2015)

A 58-year-old woman presented with a 2-week history of generalized pruritus. She also reported having fatigue, dizziness, and decreased appetite. A week before the onset of symptoms, a mild upper respiratory tract infection had developed.
Western diet for 7 weeks in apolipoprotein-E-deficient mice induces non-alcoholic steatohepatitis with significant liver fibrosis and portal hypertension
Authors: Robert Schierwagen, Frank Tacke, Winfried Reul, Dieter Luetjohann, Christian Trautwein, Sebastian Zimmer, Kanishka Hittatiya, Lara Maybuechen, Frank E. Uschner, Sabine Klein, Christer Baeck, Christian P. Strassburg, Jogchum Plat, Peter Boor, Jonel Trebicka, Georg Nickenig
Journal: Hepatology (2015)
SAT0521 Superiority of Knee Ultrasound over Radiographs in Osteophyte Detection in Knee Osteoarthritis
Authors: S. Slimani, A. Haddouche, I. Bencharif, A. Ladjouze-Rezig
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Osteophytes are important signs in knee osteoarthritis as they are one of the diagnostic criteria and are important in assessing disease severity (Kellgren-Lawrence grading). Musculoskeletal ultrasound (MSUS) is being adopted by a growing number of rheumatologists because of its cost-effectiveness and the absence of radiation exposure. <h3>Objectives</h3> The aim of the study was to evaluate the concordance of radiographs and MSUS in terms of detecting osteophytes in knee osteoarthritis. <h3>Methods</h3> A cross-sectional study in outpatients presenting with knee osteoarthritis, according to the 1990 ACR criteria for knee osteoarthritis. Radiographs of the knees (anteroposterior incidence) and MSUS of the knee have been performed for each patient. Two rheumatologists trained in MSUS (S.S and A.H) have done MSUS examinations, and had no access to patients' radiographs. Radiographs were sent and read by an independent rheumatologist (B.I) in another rheumatology center. Osteophytes were searched on 4 sites, chosen because of their easy access by both radiographs and MSUS: medial and lateral femoral condyles; medial and lateral superior tibial extremities. Osteophytes of the femoropatellar compartment have not been assessed because they require strict lateral radiographs and are not easily accessible on MSUS, thus a concordance assessment could not be reliable on this site. Concordance has been assessed using Kappa concordance coefficient. <h3>Results</h3> We have examined 192 knees of 102 patients, 76.5% females, mean age 65.2 ± 9.7 years. Radiographic analysis allowed the detection of osteophytes in 35.9% cases, with a mean number of 1.6 osteophytes per knee when present, while MSUS detected osteophytes in 86.5% cases, with a mean number of 2.7 osteophytes per knee, when present. The Kappa coefficient between radiographs and MSUS was 0.183 (95% CI: 0,138-0,228). Most of the detected osteophytes on MSUS (60.5%) were located on the femoral condyles. <h3>Conclusions</h3> Concordance between radiography and MSUS in the detection of osteophytes is poor, due to a much higher level of detection of MSUS (2.5 much more osteophytes detected with MSUS). This was made possible since new high resolutions machines were made available. The place of knee MSUS is still to be defined in the diagnostic procedure of knee pain, may be in case of normality of radiographs. To do this, studies assessing sensitivity/specificity of knee MSUS in detecting infra-radiographic knee osteoarthritis are required. <h3>Disclosure of Interest</h3> None Declared
Monoclonal Antibody Imaging of Occult Prostate Cancer in Patients With Elevated Prostate-Specific Antigen
Authors: Michael K. Haseman, Nancy L. Reed, Seth A. Rosenthal
Journal: Clinical Nuclear Medicine (1996)

The utility of monoclonal antibody (MAb) imaging for detection of occult recurrent prostate cancer was investigated in 14 patients with elevated serum prostate-specific antigen at least 3 months after therapy. All were imaged with capromab pendetide (CYT-356) and subsequently had biopsies of the prostate bed. Ten also had PET scans with F-18 fluorodeoxyglucose. Ten MAb scans were positive for tumor in the prostate bed and eight showed lymph node metastases. Six of the seven patients with positive biopsies had positive MAb scans, one had a negative scan. Three of the seven patients with negative biopsies had negative MAb scans, four had positive scans. Of the six patients with positive biopsies who had PET scans, one was positive, five were negative. Two of four patients with negative biopsies had negative positron emission tomography scans, two were positive. MAb imaging is superior to PET scan for identifying recurrent disease in the prostate bed. Assuming no false-negative biopsies, the positive predictive values for MAb and PET scan are 60% and 33%, negative predictive values are 75% and 29% and sensitivities are 86% and 17%. Additional investigation is necessary to determine if MAb uptake in lymph nodes is predictive of metastatic disease.
Abstract P3-02-13: ANALYSIS OF INFRASTRUCTURE FOR MAMMOGRAPHY SCREENING IN THE STATE OF GOIAS, BRAZIL, 2010
Authors: R Freitas-Junior, RS Correa, J-E Peixoto, DCN Rodrigues, RMS Rahal
Journal: Cancer Research (2012)

Abstract Objective: Assess the infrastructure for mammography screening in the state of Goiás, Brazil, taking into consideration the quality of the image generated by the equipment and the dose received by the patients, according to the type of technology (conventional and digital mammography). Methods: Cross-sectional study in which the observational units were the diagnostic imaging services that were in operation in 2010. In an in loco visit, we collected information on the equipment and performed tests to assess quality of the image, accuracy values for tube tension, quality of X-ray beam, and dose at the simulator entrance. The percentage of mammography equipments in conformity with the parameters evaluated was calculated, and the mean glandular tissue dose (Dg) was estimated based on the dose at the simulator entrance. To assess quality of the image and the radiation dose, we used a standard breast simulator (5.3 cm thickness and 50% glandular tissue). Results: In 2010, 102 services were in operation, using 106 equipments. Among these, 100 (94.3%) – 64 conventional and 36 digital mammography equipments – had their performance and dose assessed. The visualization of fibers (p = 0.044) and the dose at the simulator entrance (p = 0.042) were the parameters that presented differences between the types of technology. The mean dose at the simulator entrance was 9.75 mGy (± 2.46) in conventional and 14.93 mGy (± 8.39) in digital equipments (p &amp;lt; 0.001); 12% of the conventional and 50% of the digital equipments presented Dg above the limit established by the European guidelines. Conclusion: The infrastructure for mammography screening in the state of Goias, Brazil, in 2010 presented acceptable quality standard according to international guidelines. However, the radiation doses were heterogeneous between the two types of technology, with a predominance of higher doses in digital equipments. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-02-13.
Closure of a persistent esophagopleural fistula assisted by a novel endoscopic suturing system
Authors: E. Bonin, L. Wong Kee Song, Z. Gostout, J. Bingener, C. Gostout
Journal: Endoscopy (2012)

Gastrointestinal fistulas may be successfully managed endoscopically [1]. Novel endoscopic techniques for full thickness tissue approximation may serve as adjuvants for assisting fistula closure [2] [3]; an example is a flexible endoscopic suturing system [4]. We describe a case of a chronic esophageal fistula, treated previously with endoscopic clipping and esophageal stenting, which was successfully managed using a novel endoscopic suturing system [5].
SAT0034 Scavenger Receptor Expression, Glycation, and Matrix Metalloproteinase Activity in Patients with Rheumatoid Arthritis
Authors: W.-N. Huang, T. K. Tso, H.-C. Wu
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patients with rheumatoid arthritis (RA) tend to have higher incidence of atherosclerosis and the chances of stroke or myocardial infarction also increase significantly in those patients. CD36 is responsible for the major part of oxidized low-density lipoprotein (ox-LDL) uptake by macrophages, suggesting atherogenic properties for CD36. Advanced glycation end products (AGEs) are a heterogeneous group of substances formed by the nonenzymatic glycation in serum and tissues. Matrix metalloproteinases (MMPs) are responsible for the degradation of most extracellular matrix proteins and mediate tissue remodeling in a variety of pathologic conditions. <h3>Objectives</h3> The aim of this study was to identify CD36 mRNA expression and to determine its association with the circulating levels of AGEs and MMPs in patients with RA. <h3>Methods</h3> A total of 60 subjects, including thirty patients with RA and thirty healthy subjects participated in this study. Peripheral blood mononuclear cell RNA was used to analyze the CD36 mRNA expression by RT-PCR. Plasma concentrations of the AGEs, ox-LDL, receptor for AGEs (RAGE), interleukin-17 (IL-17), matrix metalloproteinases-2 (MMP-2), MMP-9, tissue inhibitor of metalloproteinases-1 (TIMP-1), and TIMP-2 were determined by enzyme-linked immunosorbent assay. <h3>Results</h3> CD36 mRNA expression in RA patients was significantly lower than healthy subjects. AGEs and MMP-9 concentrations of RA patients were significantly higher but RAGE levels were significantly lower than those in healthy subjects. RA patients have increased ox-LDL levels along with increased cardiovascular risk. In RA patients, plasma AGEs concentration positively correlated with fasting insulin, TC/HDL-C, and IL-17, whereas ox-LDL concentration positively related to MMP-2 and TC/HDL-C. <h3>Conclusions</h3> RA patients have reduced CD36 mRNA expression and decreased RAGE along with abnormal levels of AGEs and MMPs, suggesting the risk of atherosclerosis in RA patients may at least in part relate to interaction of glycation, oxidation, and MMP function. <h3>Disclosure of Interest</h3> None Declared
AB1154 Quality of life in children with haemophilic arthropathy. Assesment by euroqol:
Authors: D. El Badri, I. Bouaddi, M. Rkain, H. Rkain, F. Allali, N. Hajjaj-Hassouni
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> Haemophilia is traditionally considered to be a disease with a major impact on all aspects of quality of life (QoL). Our purpose is to explore quality of life in haemophilic children with chronic arthropathy and to search eventual factors related to deterioration of quality of life. <h3>Methods</h3> Twenty five children (all boys, age of 11.6±3.7 years, mean disease duration of 10.8±3.4years, haemophilia severe (28%) and moderate (72%)) suffering from Haemophilia with hemophilic arthropathy (affecting at least one joint) were consecutively recruited in this study. Children were asked to complete The Moroccan version of EuroQol questionnaire. We initially calculated patients' median scores for both of the EQ-5D and the different domains of the EuroQoL. <h3>Results</h3> The median of the EuroQol visual analog scale was 0.5 (0.2, 0.9). EQ-5D subscale scores were, with upgrading percentage of no difficulties answers as following: mobility, self-care and usual activities, anxiety/ depression and pain discomfort (table 1). No association was found between QoL and haemophilic arthropathy features. <h3>Conclusions</h3> Our data shows a poor quality of life in children with hemophilic arthropathy. Those children with specific needs should receive more interest from society in order to improve their quality of life. Larger studies are also required in order to search factors of hemophilic arthropathy related to a disturbed QoL. <h3>Disclosure of Interest</h3> None Declared
Abstract 2906: Curcumin reduces aberrant crypt foci (ACF) number but does not alter prostaglandin E2 (PGE2) or 5-hydroxyeicosanopentaneic acid (5-HETE) concentration in ACF or in normal human colorectal mucosa
Authors: Robert E. Carroll, D K. Turgeon, Shaiju Vareed, Madhuri Kakarala, Melissa Tuck, Chrisitne McLarin, Richard V. Benya, Frank Meyskens, Dean E. Brenner
Journal: Cancer Research (2010)

Abstract Curcumin, a dietary polyphenol derivative of turmeric, has potent cancer preventive activity in in vivo colon carcinogenesis models. To determine whether curcumin has pharmacodynamic effects on the human colon, we administered curcumin at doses of 2 g or 4 g to separate groups of 20 healthy human smokers who had 8 or more aberrant crypt foci on screening colonoscopy. We removed 3 aberrant crypt foci and 4 flat mucosal biopsies under magnifying endoscopy prior to and after 28 days of daily curcumin dosing. We enrolled 41 subjects (66% African Americans, 27% Caucasian, mean age 55+/−6.5 years). PGE2 and 5-HETE concentrations on tissue biopsies (assayed with liquid chromatography tandem mass spectroscopy) are shown in the Table. Curcumin concentrations assayed by HPLC in the colonic mucosa were undetectable (&amp;lt;10μg/gm tissue weight) while curcumin conjugate conjuges were detected in the majority of post treatment tissue samples. Curcumin does not reduce PGE2 or 5-HETE in colorectal mucosa after 28 days of administration. A daily dose of 4 g reduces ACF in colorectal mucosa. These data suggest that curcumin may reduce carcinogenesis in human colorectal mucosa but not via inhibition of arachidonic acid metabolism.‡pg/μg protein mean±SD ‡ mean±SEM p&amp;lt;0.05 PGE-2 ACFPGE-2Nl5-HETE ACF5-HETE NlACFPre-Treatment-2g1.2±1.8‡2.1±3.21.4±0.92.3±1.315.7±1.3Post-Treatment-2g1.6±1.82.8±3.71.4±1.02.4±1.215.0±1.5Pre-Treatment-4g3.4±4.82.7±1.92.3±1.32.4±1.517.8±2.0Post-Treatment-4g3.7±3.22.6±2.92.4±1.22.2±1.611.1±2.8† (Support: NCI N01-35610, F. Meyskens PI Univ California Irvine) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2906.
SP0016 The ABC of Diagnostic and Prognostic Tests
Authors: L. Carmona
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> You have a biomarker, or a questionnaire, or a set of criteria, or any other tool by which you want to be able to diagnose persons with a specific disease, or to predict a disease in the future. The idea is that such a tool should be able to detect the presence or absence of a particular process: it should classify, with none or little error, subjects into healthy or sick. As you can imagine, this is very complex by the single reasoning that health is not black and white, but more like a spectrum. In addition, you need to test your diagnostic tool by determining the degree of similarity between the results of your tool and an external criterion. This criterion, in principle, says the truth about the condition of the patients: disease yes/disease no. Although everything seems very easy in diagnostic tests reasoning, as we make everything to fall into a 2x2 table, it is not that simple, and biases appear at every corner. There is also a lot of circularity, and the literature is full – yes, even in our field, and even in our best journals – of examples of wrong designs and interpretations. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6172
USE OF EVIDENCE-BASED MEDICATIONS FOR CORONARY ARTERY DISEASE AND DIABETES IN WOMEN AND MEN WITH OUT OF HOSPITAL SUDDEN UNEXPECTED DEATH IN THE SUDDEN UNEXPECTED DEATH IN NORTH CAROLINA (SUDDEN) STUDY
Authors: Zachariah Deyo, Mitchell Conover, Irion Pursell, Sarah Chen, Brooke Namboodri, John Mounsey, Ross Simpson
Journal: Journal of the American College of Cardiology (2016)
RM-03 * ACQUISITION OF STEM-CELL PHENOTYPE THROUGH EPITHELIAL MESENCHYMAL TRANSITION IN GLIOBLASTOMA
Authors: Y. Iwadate, A. Suganami, Y. Tamura, T. Matsutani, S. Hirono, N. Shinozaki, S. Ikegami, N. Saeki
Journal: Neuro-Oncology (2014)

The stem cell phenotype including high motility of the cells and resistance to apoptosis usually contributes to the aggressiveness of glioblastoma (GB). To examine the molecular mechanisms of treatment resistance, we comprehensively compared protein expressions between a group of patients with good prognosis (survival >4 years) and a group with poor prognosis (survival <12 months) using multidisciplinary proteomics. Mass spectrometry-based proteomics revealed a frequent up-regulation of the signal transduction proteins in the poor prognosis group (9 out of 19 proteins identified), which included Rac1 and RhoA that are important in epithelial-mesenchymal transition (EMT). An antibody microarray showed that pluripotent stem-cell marker, alkaline phosphatase (AP), and an EMT inducer, Arf6, were the top-significant candidates that were up-regulated among 165 signal transduction proteins in the poor prognosis group. We confirmed the high expressions of these proteins by immunohistochemistry as well as CD133, CD44, Rac1, and Twist to be highly correlated with poor prognosis. The expressions of Arf6, Rac1, and Twist were highly correlated with CD44 expression. A ratio of necrotic area on GB tissue sections was significantly higher in the poor prognosis group and correlated with the expressions of Arf6 and Twist. The genome-wide DNA methylation profile indicated that the poor prognosis group had more hypomethylated CpG sites compared with the good prognosis groups. The CpG sites in the AP gene were more frequently methylated in the good prognosis group. These results collectively show that the stem-cell-related proteins are induced by EMT due to DNA hypomethylation, which contributes to the poor prognosis of GBs and may be a treatment target.