tbuckley/cabot-search huggingface dataset:
Abstract LB-76: Services of a Cancer Center
Authors: Virginia Mapara
Journal: Cancer Research (2011)

Abstract The Cancer Center in Harare is part of the Cancer Association in Zimbabwe. It is a nonprofit organization supported by donations from the public. The outreach programs and cancer assistance services are given free to the patients, institutions and the community. The association was formed in Bulawayo, its headquarters, in 1959, and then in Harare in 1961. The center is committed to empowering clients and their families to cope with the crisis of dealing with cancer through a holistic approach which will enable the client to develop a positive attitude to the disease throughout their treatment. The center provides the community with information to promote healthy lifestyle choices and to increase public awareness on the prevention and early detection of cancer. The center seeks also seeks to: promote prevention of cancer through public awareness, talks and lectures; carry out counseling services and give psychological support; provide complimentary health therapies to those diagnosed of cancer; teach breast care, breast self examination and manages a breast care clinic; give nutritional advice to the cancer patients; and serve as a resource centre for patients through use of the library. The activities of the center include giving lectures, talks and print media to schools, corporate organizations and communities. Information on cancer is also given over radio, television and through the distribution of quarterly newsletters. Counseling services are provided to those diagnosed of cancer and their families. The organization also offers counseling services to patients in hospitals during chemotherapy and radiotherapy. The center provides a wide range of complimentary health therapies such as relaxation and meditation classes, aromatherapy (massage) reflexology, Reiki, shiatsu and use of rife therapy. Awareness campaigns are recognized and health education programs are intensified such as the worldwide recognized No Tobacco Day, Breast Cancer Awareness Month, and World Cancer Day. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-76. doi:10.1158/1538-7445.AM2011-LB-76
18fF-FDG PET/CT for Detection of Leukemic Transformation in Myelofibrosis
Authors: Thorsten Derlin, Till Sebastian Clauditz, Nicolaus Kröger
Journal: Clinical Nuclear Medicine (2015)

Myelofibrosis is a rare clonal hematopoietic stem cell disorder characterized by chronic myeloproliferation, atypical megakaryocytic hyperplasia, and potential leukemic transformation. We report a case of leukemic transformation detected by F-FDG PET/CT. A 56-year-old woman with myelofibrosis and newly diagnosed space-occupying lesion of the chest wall underwent whole-body PET/CT for further evaluation. F-FDG PET demonstrated marked tracer uptake within that lesion. Histopathological evaluation revealed myeloid sarcoma evidencing leukemic transformation. F-FDG PET/CT is a valuable tool-enabling sensitive detection of leukemic transformation in myelofibrosis, particularly in case of extramedullary organ involvement.
INFRASTRUCTURE FOR THE MEDICAL CARE OF PATIENTS WITH IBD IN THE REPUBLIC OF IRELAND; PRELIMINARY RESULTS OF A NATIONAL ELECTRONIC SURVEY
Authors: A O'Connor, B Egan, M Forry, J Keohane, L Jackson, L Egan, G Doherty
Journal: Gut (2013)

<h3>Introduction</h3> The UK National IBD Audit (now in its fourth cycle) has focused attention on quality of care for IBD patients and has lead to the generation of agreed national standards of care in the UK. <h3>Aims/Background</h3> This project was performed to gather baseline information on the infrastructure for care of patients with IBD in Ireland using elements adapted from the UK National IBD Audit. <h3>Method</h3> An invitation to participate in an electronic survey was distributed by post and e-mail to Consultant Gastroenterologists and ISG members in the Republic of Ireland. The survey was conducted by an independent market research organization. <h3>Results</h3> n=13 responses were received; 4 responses from HSE hospitals, 4 responses from public voluntary hospitals, 5 responses from private centres. Only 4/13 (31%) of centres have an identified ward for the care of hospitalised patients with IBD. In 7/13 cases, the ratio of beds to lavatories for in-patients exceeds 3 (maximum 7 beds). All respondents rated the role of the IBD nurse as important or very important in the care of IBD patients. 11/13 reported somewhat or very limited access to magnetic resonance enterography (MRE) for small bowel imaging; 5/13 respondents reported out-patient waiting times exceeding 12 weeks for MRE. Most centres highlighted a lack of IBD nurses, IBD specialists and waiting times for diagnostic tests as important current barriers to optimal care for IBD patients. <h3>Conclusion</h3> Preliminary results of the first national survey of the infrastructure for care of IBD patients have highlighted important areas for improvement. The ratio of beds to lavatories on in-patient wards recommended by the UK National IBD standards is exceeded in most centres. There is poor access to MRE in many sites, leading to avoidable exposure to ionising radiation. The survey emphasises the importance of the IBD nurse specialist in patient care. The findings identify priority areas for improving the quality of care for IBD patients in the Republic of Ireland.
INCIDENCE OF CORONARY ARTERY DISEASE AND STROKE IN RELATION TO THE PHYSICAL COURSE OF RESISTANT HYPERTENSION: A TIME UPDATED ANALYSIS OF A 4 YEAR COHORT STUDY
Authors: Konstantinos P. Tsioufis, Athanasios Kordalis, Alexandros Kasiakogias, Kyriakos Dimitriadis, Konstantinos Thomopoulos, Konstantinos Kintis, Dimitris Flessas, Ioannis Liatakis, Dimitris Roussos, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2015)
SAT0316 Relationship of ultrasonographic measurement of osteophytes and femoral cartilage thickness to radiographic severity of knee osteoarthritis:
Authors: A. Mathiessen, I.K. Haugen, P.S. Robinson, C.N. Engen, N. Østerås, L. Engebretsen, T.K. Kvien, H.B. Hammer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Conventional radiography is the main outcome measure in epidemiological studies of osteoarthritis (OA), but the use of ultrasound (US) has gained increased interest with ability to visualize both osteophytes and soft tissue structures. <h3>Objectives</h3> To explore the relationship between ultrasonographic features of knee OA (osteophytes and femoral cartilage thickness) and degrees of radiographic knee OA. <h3>Methods</h3> We included 234 participants (160 women, mean (SD) age 64.4 (8.7) years) from the MUST study (“the Musculoskeletal pain in Ullensaker Study”), which is a population-based study of persons with self-reported OA of the knee, hand and/or hip joints. The US examination included assessment of femoral and tibial osteophytes (grade 0-3) in the medial and lateral compartments using longitudinal scan positions on extended knees, and measure of femoral cartilage thickness (millimetres) at the medial and lateral condyles and in the notch with the probe transversely at the distal femur with knee in maximum flexion (5-13 MHz probe, Siemens Antares). The highest osteophyte score and lowest cartilage thickness in each knee was used in our analysis. Radiographs were read using the Kellgren-Lawrence (KL) scale (0-4). We calculated the prevalence of osteophytes and the mean (SD) cartilage thickness in knees with no OA (KL grade 0), doubtful (KL grade 1), mild (KL grade 2) and moderate/severe OA (KL grade ≥3). KL grades 3 and 4 were evaluated together due to few joints in each category (n=44 and n=7, respectively). <h3>Results</h3> Fifty-eight joints were excluded due to knee replacement or amputation. In 410 assessed knee joints, the prevalence and severity of US osteophytes increased with radiographic severity (table). A high proportion of US osteophytes were also found in joints with no/doubtful OA (KL ≤1). We did not find lower cartilage thickness with increasing radiographic severity (table). <h3>Conclusions</h3> This study demonstrates a clear relationship between US detected osteophyte scores and increased radiographic severity of OA, but no association between femoral cartilage thickness and radiographic OA was found. The results indicate that US examination of osteophytes may be useful in the clinical setting for evaluation of knee OA, but the validity and usefulness of US in measuring cartilage thickness in knees may be questioned. <h3>Disclosure of Interest</h3> None Declared
Abstract 2299: Genistein suppresses prostate cancer growth through inhibition of oncogenic miR-151
Authors: Takeshi Chiyomaru, Mohd Saif Zaman, Shahana Majid, Guoren Deng, Soichiro Yamamura, Varahram Shahryari, Sharanjot Saini, Hiroshi Hirata, Koji Ueno, Inik Chang, Yuichiro Tanaka, Hideki Enikida, Masayuki Nakagawa, Rajvir Dahiya
Journal: Cancer Research (2012)

Abstract Introduction and Objective: Genistein has been shown to suppress the growth of several cancer cell lines in vitro and in vivo, reducing the expression of several oncogenic microRNAs. However, the effects of genistein on the regulation of oncogenic miR-151 have not been reported. In this study, we investigated whether genistein could alter the expression of oncogenic miR-151 and its target genes that are involved in the progression and metastasis of prostate cancer. Methods: The expression levels of miR-151 were analyzed by TaqMan quantitative real-time PCR and normalized to RNU48. Nineteen clinical specimens were obtained from patients at the San Francisco Veterans Affairs Medical Center from 2000 to 2006. For gain-and loss-of-function assay, cell proliferation (MTS assay), migration (wound healing assay), and invasion (matrigel invasion assay) were evaluated in human prostate cancer cell lines, PC3 and DU145. Predicted target genes and their target microRNA binding site seed regions were investigated using TargetScan and microRNA.org. Genistein was administered every day along with a change of medium, and the cells were grown for four days. Results: Real-time RT-PCR showed that the expression of miR-151 was higher in PC3 and DU145 cells compared with RWPE-1 cells. Treatment of PC3 and DU145 cells with 25 μM genistein down-regulated the expression of miR-151 compared with vehicle control. Kaplan-Meier curves and log-rank tests revealed that high expression levels of miR-151 had a significant adverse effect on survival rate. Inhibition of miR-151 in prostate cancer cells by genistein significantly inhibited cell migration and invasion. By in-cilico analysis, several genes (N4BP1, CASZ1, IL1RAPL1, LGI1, SOX17 and TOM1L1) that are suggested to have tumor suppressive function in several types of cancers were detected as candidate target genes of miR-151. Conclusions: We demonstrated that genistein down-regulated miR-151 that functions as an oncogenic miRNA in prostate cancer. This study suggests that genistein mediated suppression of oncogenic miRNAs can be an important dietary therapeutic strategy for the treatment of prostate cancer. Source of Funding: Grants R01CA160079-01, R01CA138642, VA Research Enhancement Award Program (REAP), and VA Merit Review grants Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2299. doi:1538-7445.AM2012-2299
Pulmonary mucosa-associated lymphoid tissue lymphoma revisited
Authors: Raphael Borie, Marie Wislez, Martine Antoine, Christiane Copie-Bergman, Catherine Thieblemont, Jacques Cadranel
Journal: European Respiratory Journal (2016)

This general review sought to clarify the pathophysiological, diagnostic, prognostic, and therapeutic features of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma. MALT lymphoma is the most common pulmonary B-cell lymphoma, which usually occurs in the context of acquired MALT. The disease is slow-growing with an asymptomatic chronic alveolar opacity visible on radiography. Diagnosis requires tissue samples that should be retrieved using minimally invasive techniques, such as bronchoscopy or computed tomography-guided biopsies. The pathophysiology includes cytogenetic abnormalities and autoimmune diseases, whereas an association with a chronic pulmonary infection is still suspected but not yet demonstrated. Disease prognosis is typically excellent and the current available treatments are discussed in this review, including the decision not to treat, surgery, and single- or double-agent chemotherapy.
FRI0216 Effect of concomitant statins on rituximab efficacy in patients with ra
Authors: A. Vashishtha, P. B. Lehane, E. W. Hessey
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> There are conflicting reports regarding whether concomitant administration of HMG-CoA reductase inhibitors (statins) affects the clinical efficacy of rituximab (RTX) in RA.<sup>1,2</sup> <h3>Objectives</h3> To investigate the impact of statin co-administration on RTX efficacy in patients from RA clinical trials. <h3>Methods</h3> Retrospective pooled analysis of data from 4 RA clinical trials (DANCER, REFLEX, SERENE and IMAGE) involving patients with moderate to severe RA treated with RTX (investigational dose of 2 x 500 mg or approved dose of 2 x 1000 mg) + MTX per protocol, with stable oral corticosteroid dose (≤10 mg prednisone or equivalent). Baseline characteristics and efficacy responses (change in DAS28-ESR from baseline, ACR20, ACR50) at 24 wks following one course of RTX, were compared in patients receiving statins for ≥8 wks of the 24-wk treatment period (STY) vs receiving statins for &lt;8 wks, or not at all (STN). A sensitivity analysis comparing patients receiving statins at baseline vs those who were not was also undertaken. Change in DAS28-ESR between groups was tested using an analysis of covariance (ANCOVA) model adjusted for RTX dose, age, sex, RA duration, RF status and baseline DAS28-ESR. Interactions between age and RA duration, and RTX dose and statin use were also tested. ACR20 and ACR50 responses were tested using a logistic regression model adjusting for the same covariates as the ANCOVA except for baseline DAS28-ESR. <h3>Results</h3> Of 1460 patients, 104 (7.1%) had received concomitant statins. Baseline characteristics are shown in the table. On average, STY patients were older, more frequently male, had longer RA disease duration, and had received more prior DMARD and biologic therapy vs STN patients. DAS28-ESR was similar between groups. <h3>Conclusions</h3> Whilst acknowledging the limitations inherent in a retrospective efficacy analysis of pooled data from several RTX clinical trials in RA, this analysis evaluated the possible impact of concomitant administration of statins at baseline or for ≥8 wks during a 24-wk treatment period, and adds to the data available on this topic. <h3>References</h3> Arts et al. Ann Rheum Dis 2010;70:877; Das et al. Ann Rheum Dis 2012;71(Suppl 3):196. <b>Disclosure of Interest</b>: A. Vashishtha Employee of: Genentech Inc., P. Lehane Employee of: Roche Products Ltd, E. Hessey Shareholder of: F. Hoffmann La-Roche, Employee of: Roche Products Limited
Probucol and Multivitamins in the Prevention of Restenosis after Coronary Angioplasty
Authors: J C Tardif, G Cöté, J Lespérance, M Bourassa, J Lambert, S Doucet, L Bilodeau, S Nattel, P de Guise
Journal: New England Journal of Medicine (1997)

Oxidizing metabolites generated at the site of coronary angioplasty can induce chain reactions that may lead to restenosis. Antioxidants may counter oxidative stress and modify neointimal formation and vascular remodeling. Experimental data and small clinical studies have suggested that antioxidants may prevent restenosis after angioplasty. In a double-blind, randomized trial, we studied whether drugs with antioxidant properties decrease the incidence and severity of restenosis after angioplasty.
Expression in Non-Hodgkin's Lymphoma of the<i>bcl</i>-2 Protein Associated with the t(14;18) Chromosomal Translocation
Authors: Bo-Yee Ngan, Zehava Chen-Levy, Lawrence M. Weiss, Roger A. Warnke, Michael L. Cleary
Journal: New England Journal of Medicine (1988)

For many non-Hodgkin's lymphomas, the bcl-2 gene has been implicated as a likely proto-oncogene, since it is consistently located at or near the breakpoint sites of t(14;18) chromosomal translocations. To define the role of the protein product of the bcl-2 gene in lymphoid cancers, we used anti-bcl-2 antibodies to perform immunohistochemical studies of frozen sections of 136 tissue specimens affected by lymphoma or non-neoplastic lymphoid disorders. Immunoreactive bcl-2 protein was observed in the neoplastic cells in almost all the follicular lymphomas, whereas no bcl-2 protein was detected in follicles affected by non-neoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t(14;18) translocation expressed detectable levels of bcl-2 protein, regardless of whether the breakpoint was located in or at a distance from the bcl-2 gene. These data show consistent expression of a proto-oncogenic protein in a large proportion of non-Hodgkin's lymphomas and provide further support of a role for bcl-2 in the pathogenesis of all lymphomas with the t(14;18) karyotypic abnormality. Increased expression of bcl-2 after t(14;18) translocations may be a specific marker for B-cell cancers, and demonstration of the protein with use of anti-bcl-2 antibodies could be useful in the diagnosis of many non-Hodgkin's lymphomas.
Abstract P1-11-14: Neoadjuvant Chemotherapy in Lobular and Ductal Carcinoma: Comparison of Clinical, Pathological Response Rates and Survival
Authors: F Coussy, C Cuvier, AS Hamy, S Giacchetti, A De Roquancourt, M. Espié
Journal: Cancer Research (2010)

Abstract Introduction: Neoadjuvant chemotherapy is a standard of care in locally advanced breast carcinomas. The major purpose of neoadjuvant chemotherapy is breast conserving surgery. Advantages in survival have only been shown in patients undergoing achieving pathological complete response (pCR). Lobular carcinomas seem less chemosensitive than ductal carcinomas to neoadjuvant chemotherapy (NCT). Purpose: To compare the clinical and pathological response rate and the outcome of lobular (ILC) versus ductal (IDC) invasive breast carcinomas after NCT. Patients and methods: Between 1985 and 2010, 385 patients with locally advanced and/or inflammatory breast carcinomas from Saint Louis hospital received neoadjuvant chemotherapy. Forty-four (11, 4%) ILC and 341 (88, 6%) IDC were diagnosed by surgical or core needle biopsy before CT. All patients received anthracyclines based CT,181 (47%) additionally received a taxane (four cycles of epirubicin 75 mg/m2 and cyclophosphamide 750 mg/m2 then four cycles of taxotere 100mg/m2 or six cycles of a dose dense regimen of 75 mg/m2 epirubicin and 1200mg/m2 cyclophosphamide, every 14 days),and underwent breast surgical excision (lumpectomy or mastectomy) and axillary node dissection.Clinical response was defined by the lack of palpable tumor in the breast before surgery.Pathological complete response was defined by no residual invasive tumor in breast. Radiotherapy and hormonotherapy were delivered to patients, when appliable. Results: Clinical response to NCT was higher for ILC (27, 3%) than IDC (13,4%). ILC with clinical response tended to have higher histological grade 2 (91,6 % versus 30,4% for IDC),more estrogens receptors (RE) positivity (91,6% vs 45,6%), p53 wild type (66,6% vs 30,4%) and HER2- negative tumors (91,6% vs 76%) Pathologic response (pCR) rate was lower for ILC than for IDC (2, 7% vs 9, 3%). Only one ILC (grade 2, RE+, HER2 negative, p53 wild type) underwent pCR. Thirty two (9, 3%) IDC haved pCR: 15,6% haved histological grade 2, 15,6% RE positivity,9,3% p53 wild type, 62,5% HER2 negative. Thirteen percent of ILD and 9 % of ILC haved breast conservating surgery .At a median follow up of 60 months, ILC patients tended to have longer overall survival (55% vs 48%) and recurrence free survival (44% vs 36,8%) than IDC. Conclusions: ILC was characterized by better clinical response rates but lower pathologic response and breast conservating surgery rates .Despite the low pCR rate, patients with ILC tended to have better outcomes than did patients with IDC. Pathological complete response to NCT in ILC did not seem to have prognostic significance. Further data are warranted to help clarify the characteristics genomics and proteomics of ILC which explains this better outcome. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P1-11-14.
TRICUSPID REGURGITATION IS ASSOCIATED WITH PULMONARY HEMODYNAMICS AND RIGHT VENTRICULAR DYSFUNCTION IN PULMONARY ARTERIAL HYPERTENSION BUT DOES NOT ALTER THE GEOMETRY OF RIGHT VENTRICULAR CONTRACTION
Authors: Jose Ricardo Po, Talha Meeran, Ryan Davey, Raymond Benza, Amresh Raina
Journal: Journal of the American College of Cardiology (2016)
SAT0542 Oxidative Stress by Monosodium Urate Crystals Promotes Renal Cell Apoptosis through Mitochondrial Caspase-Dependent Pathway in Human Embryonic Kidney 293 Cells
Authors: S.-K. Kim, J.-Y. Choe, S.-H. Park, H. Lee
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Apoptosis plays a crucial role in not only renal physiological homeostasis but also development of renal damage. Hyperuricemia is well known to lead to impairment of renal function. <h3>Objectives</h3> The aim of this study is to clarify the mechanism of monosodium urate (MSU)-medicated apoptosis of renal cells. <h3>Methods</h3> The quantitative real time-polymerase chain reaction and immonoblotting for Bcl-2, caspase-9, caspase-3, iNOS, COX-2, interleukin-1b (IL-1b), or IL-18 <i>using</i> human embryonic kidney 293 (HEK293) cell line, which was stimulated by MSU crystals. Fluorescence-activated cell sorter (FACS) for apoptosis was performed using annexin V. Reactive oxygen species (ROS) assay was measured. siRNA IL-1b was used for blocking IL-1b expression. <h3>Results</h3> MSU crystals promoted ROS generation and IL-1b and IL-18 mRNA expressions in HEK293 cells, which were inhibited by ascorbic acid. Exposure of MSU crystals to HEK293 cells induced caspase-dependent apoptosis pathway through down-regulation of Bcl-2 and enhanced caspase-3 and caspase-9 expression in gene and protein levels, which were significantly reversed by ascorbic acid. Enhanced annexin V positive cells by MSU crystals were attenuated by ascorbic acid and siRNA IL-1b. ROS generation by MSU crystals activated TNF receptor associated factor-6 and mitogen-activated protein kinases (MAPKs) of IL-1b signaling. Inhibitors for MAPKs attenuated ROS production. Blocking IL-1b expression using siRNA IL-1b inhibited caspase-dependent apoptosis pathway in HEK293 cells. <h3>Conclusions</h3> ROS generated by MSU crystals promote renal apoptosis through mitochondrial caspase-dependent apoptosis pathway. It suggests that blocking ROS and IL-1b could be considered a therapeutic strategy in the prevention of renal damage caused by MSU crystals. <h3>Acknowledgements</h3> This work was supported by a grant from the Research Institute of Medical Science, Catholic University of Daegu (2013). <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2630