tbuckley/cabot-search huggingface dataset:
Office Visits Prior to Screening Colonoscopy
Authors: Jeffrey J. Leow, Quoc Dien Trinh, Julia McNabb-Baltar
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Behavioral characteristics of children with chronic nonspecific diarrhea
Authors: E H Wender, F B Palmer, J J Herbst, P H Wender
Journal: American Journal of Psychiatry (1976)

The authors obtained early case histories of 16 children with chronic nonspecific diarrhea and 16 control subjects and found that the index subjects had a significantly higher frequency of sleep problems, crying and irritability, digestive problems excluding diarrhea, overactivity, resistance to discipline, and family history of gastrointestinal problems. They conclude that these behavioral characteristics represent temperamental traits based on physiological factors, perhaps an imbalance of autonomic nervous system function. They speculate that chronic nonspecific diarrhea may occur in association with certain temperamental traits because both the somatic and psychic components stem from a common disturbance in autonomic nervous system function.
Extranodal diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Authors: U. Vitolo, J.F. Seymour, M. Martelli, G. Illerhaus, T. Illidge, E. Zucca, E. Campo, M. Ladetto
Journal: Annals of Oncology (2016)
P-020 Targeting multidrug resistance – associated protein 4 (MRP4/ABCC4) in pancreatic cancer
Authors: M. May, C. Alejandro, N. Gomez, F. Diez, S. Copsel, J. Iturbe, N. Mohr, N. Fernandez, C. Shayo, C. Davio
Journal: Annals of Oncology (2016)
Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphisms
Authors: L. Adams, A. Wree, P. Melton, G. Jeffrey, H. Ching, B. de Boer, J. Olynyk, O. Ayonrinde, T. Mori, L. Beilin, Patricia Price, C. Pennell, M. Eslam, J. George, A. Feldstein
Journal: Hepatology (2015)
Favorable Outcome in a Large Cohort of Prospectively Treated Adult Patients with T-Lymphoblastic Lymphoma (T-LBL) Despite Slowly Evolving Complete Remission Assessed By Conventional Radiography
Authors: Nicola Gökbuget, Andrea Wolf, Matthias Stelljes, Andreas Hüttmann, Eike C. Buss, Andreas Viardot, Kalina Brandt, Maike de Wit, Norbert Frickhofen, Maxim Kebenko, Mustafa Kondakci, Doris Kraemer, Stefan Schwartz, Hubert Serve, Karsten Spiekermann, Reingard Stuhlmann, Albrecht Reichle, Dieter Hoelzer
Journal: Blood (2014)
Correlates of lateral ventricular size in chronic schizophrenia, I: Behavioral and treatment response measures
Authors: M F Losonczy, I S Song, R C Mohs, N A Small, M Davidson, C A Johns, K L Davis
Journal: American Journal of Psychiatry (1986)

The ventricle-brain ratio (VBR) of 28 drug-free male schizophrenic inpatients was significantly higher than that of 21 matched normal control subjects and was not related to severity of positive or negative symptoms. Response to haloperidol in an open 6-week trial using a fixed-dose schedule was not predicted by severity of positive or negative symptoms or by VBR. The nine severely deteriorated patients with chronic "Kraepelinian" schizophrenia had left lateral ventricles 28% larger than their right, whereas the control subjects and other schizophrenic patients did not show ventricular asymmetry.
Case 42-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Ronald J. Anderson, Eugene J. Mark
Journal: New England Journal of Medicine (1976)

Presentation of Case First admission. A 49-year-old Venezuelan man was admitted to the hospital because of fever.Aside from occasional bouts of renal colic he was well until six months previously, when diarrhea developed. Examination of a stool specimen revealed evidence of infestation with Strongyloides stercoralis and Entamoeba histolytica and a small amount of occult blood; there was no evidence of Chagas's disease. Diodoquin, metronidazole and chlorphenoxamide were administered. One month later, while he was still receiving treatment, arthralgia occurred, with a daily rise of the temperature to 38°C, accompanied by shaking chills, malaise, anorexia and edema of the hands . . .
Case 29-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Ralph C. Williams, Robert T. McCluskey
Journal: New England Journal of Medicine (1976)

Presentation of CaseA 41-year-old man was admitted to the hospital because of aortic-valve disease.In his 20's he experienced repeated bouts of renal colic, without apparent residual damage. Twenty years before admission pain in the knees developed, and a biologic false-positive Wassermann test was found. Five years later there was the onset of polyarthritis, and a diagnosis of rheumatoid arthritis was made. A positive test for syphilis was again found, but a Treponema pallidum immobilization test was negative on two occasions. Six years before entry he underwent a course of gold therapy for 17 weeks; the treatment was terminated . . .
Epidémie d'infections à Salmonella enteritidis associée à un gâteau avec glaçage
Authors: P D'Argenio, A Romano, F Autorino
Journal: Eurosurveillance (1999)

Apres un banquet de premiere communion a Benevento, une ville de 60 000 habitants au sud de l’Italie, plusieurs participants ont developpe de graves symptomes de gastro-enterite. Ce banquet, auquel une soixantaine de personnes participaient, s’est tenu le 14 juin 1998 entre 14 et 18 heures. Les autorites nationales, informees de cette epidemie le 16 juin par un medecin generaliste, ont immediatement debute une investigation afin d’identifier l’agent responsable, l’aliment contamine et les eventuelles erreurs commises lors de sa preparation.
Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents
Authors: Dongryeol Ryu, Laurent Mouchiroud, Pénélope A Andreux, Elena Katsyuba, Norman Moullan, Amandine A Nicolet-dit-Félix, Evan G Williams, Pooja Jha, Giuseppe Lo Sasso, Damien Huzard, Patrick Aebischer, Carmen Sandi, Chris Rinsch, Johan Auwerx
Journal: Nature Medicine (2016)
ESMO consensus guidelines for the management of patients with metastatic colorectal cancer
Authors: E. Van Cutsem, A. Cervantes, R. Adam, A. Sobrero, J.H. Van Krieken, D. Aderka, E. Aranda Aguilar, A. Bardelli, A. Benson, G. Bodoky, F. Ciardiello, A. D'Hoore, E. Diaz-Rubio, J.-Y. Douillard, M. Ducreux, A. Falcone, A. Grothey, T. Gruenberger, K. Haustermans, V. Heinemann, P. Hoff, C.-H. Köhne, R. Labianca, P. Laurent-Puig, B. Ma, T. Maughan, K. Muro, N. Normanno, P. Österlund, W.J.G. Oyen, D. Papamichael, G. Pentheroudakis, P. Pfeiffer, T.J. Price, C. Punt, J. Ricke, A. Roth, R. Salazar, W. Scheithauer, H.J. Schmoll, J. Tabernero, J. Taïeb, S. Tejpar, H. Wasan, T. Yoshino, A. Zaanan, D. Arnold
Journal: Annals of Oncology (2016)
Diagnostic accuracy of the γ-glutamyl transpeptidase to platelet ratio to predict liver fibrosis in Egyptian patients with HCV genotype 4
Authors: Yusuke Shimakawa, Philippe Bonnard, Mohamed El Kassas, Mohamed Abdel-Hamid, Gamal Esmat, Arnaud Fontanet
Journal: Gut (2016)

Given the high disease burden with viral hepatitis, and the advent of highly effective direct-acting antivirals against HCV infection, the WHO is now developing a global strategy to eliminate viral hepatitis by 2030.1 Increasing the uptake of HCV diagnosis and treatment will become a key intervention in achieving this goal.

Although antiviral drugs should be considered for all persons with chronic HCV infection, those with significant liver fibrosis, and especially cirrhosis, should be prioritised for treatment, as they are at increased risk of hepatic complications. Current WHO guidelines for HCV recommend aspartate aminotransferase (AST)-to-platelet ratio index (APRI) or Fib-4 for the fibrosis assessment in low/middle-income countries (LMIC), because of their low cost and wide availability.2 Recently, Lemoine et al 3 developed a novel simple index called γ-glutamyl transpeptidase (GGT) to platelet …
Immunity to Commensal Fungi: Detente and Disease
Authors: Matthew L. Wheeler, Jose J. Limon, David M. Underhill
Journal: Annual Review of Pathology Mechanisms of Disease (2017)

Fungi are ubiquitous in our environment, and a healthy immune system is essential to maintain adequate protection from fungal infections. When this protection breaks down, superficial and invasive fungal infections cause diseases that range from irritating to life-threatening. Millions of people worldwide develop invasive infections during their lives, and mortality for these infections often exceeds 50%. Nevertheless, we are normally colonized with many of the same disease-causing fungi (e.g., on the skin or in the gut). Recent research is dramatically expanding our understanding of the mechanisms by which our immune systems interact with these organisms in health and disease. In this review, we discuss what is currently known about where and how the immune system interacts with common fungi.
Effect of nivolumab on health-related quality of life in patients with treatment-naïve advanced melanoma: results from the phase III CheckMate 066 study
Authors: G.V. Long, V. Atkinson, P.A. Ascierto, C. Robert, J.C. Hassel, P. Rutkowski, K.J. Savage, F. Taylor, C. Coon, I. Gilloteau, H.B. Dastani, I.M. Waxman, A.P. Abernethy
Journal: Annals of Oncology (2016)

Nivolumab has shown significant survival benefit and a favorable safety profile compared with dacarbazine chemotherapy among treatment-naïve patients with metastatic melanoma in the CheckMate 066 phase III study. Results from the health-related quality of life (HRQoL) analyses from CheckMate 066 are presented.HRQoL was evaluated at baseline and every 6 weeks while on treatment using the European Organisation for Research and Treatment of Care (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and the EuroQoL Five Dimensions Questionnaire (EQ-5D). Via a multi-step statistical plan, data were analyzed descriptively, cross-sectionally, and longitudinally, adjusting for baseline covariates, in patients having baseline plus ≥1 post-baseline assessment.Baseline-adjusted completion rates for all HRQoL questionnaires across treatment arms were 65% and 70% for dacarbazine and nivolumab, respectively, and remained similar throughout treatment. The mean baseline HRQoL scores were similar for patients treated with nivolumab and dacarbazine. Baseline HRQoL levels with nivolumab were maintained over time. This exploratory analysis showed a between-arm difference in favor of nivolumab on the EQ-5D utility index and clinically meaningful EQ-5D improvements from baseline at several time points for patients receiving nivolumab. Patients treated with nivolumab did not show increased symptom burden as assessed by the EORTC QLQ-C30. No HRQoL change was noted with dacarbazine patients up to week 43, although the high attrition rate after week 13 did not allow any meaningful analyses. Patients receiving nivolumab deteriorated significantly later than those receiving dacarbazine on several EORTC QLQ-C30 scales and the EQ-5D utility index.In addition to prolonged survival, these exploratory HRQoL results show that nivolumab maintains baseline HRQoL levels to provide long-term quality of survival benefit, compared with dacarbazine in patients with advanced melanoma.
PD3-3-3: Safety of bevacizumab therapy in subjects with brain metastases due to non-small cell lung cancer (NSCLC)
Authors: Wallace Akerley, John Hainsworth, Yun Oh, Dk Strickland, Stephanie Royer-Joo, Xian Zhou, Qi Xia, Jane Huang
Journal: Journal of Thoracic Oncology (2007)
Rediscovery
Authors: Rey P Vivo
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Musical Instruments
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Screening for Skin Cancer: U.S. Preventive Services Task Force Recommendation Statement
Journal: Annals of Internal Medicine (2009)

Description: Update of the 2001 U.S. Preventive Services Task Force (USPSTF) recommendation statement on screening for skin cancer. Methods: To update its recommendation, the USPSTF reviewed evidence published since 2001 on studies on screening effectiveness, the stage of detection by screening, and the accuracy of whole-body examination by primary care clinicians and self-examination by patients. Recommendation: The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for skin cancer by primary care clinicians or by patient skin self-examination. (I statement)
Waterborne outbreaks in the Nordic countries, 1998 to 2012
Authors: B Guzman-Herrador, A Carlander, S Ethelberg, B Freiesleben de Blasio, M Kuusi, V Lund, M Löfdahl, E MacDonald, G Nichols, C Schönning, B Sudre, L Trönnberg, L Vold, J C Semenza, K Nygård
Journal: Eurosurveillance (2015)

A total of 175 waterborne outbreaks affecting 85,995 individuals were notified to the national outbreak surveillance systems in Denmark, Finland and Norway from 1998 to 2012, and in Sweden from 1998 to 2011. Between 4 and 18 outbreaks were reported each year during this period. Outbreaks occurred throughout the countries in all seasons, but were most common (n = 75/169, 44%) between June and August. Viruses belonging to the Caliciviridae family and Campylobacter were the pathogens most frequently involved, comprising n = 51 (41%) and n = 36 (29%) of all 123 outbreaks with known aetiology respectively. Although only a few outbreaks were caused by parasites (Giardia and/or Cryptosporidium), they accounted for the largest outbreaks reported during the study period, affecting up to 53,000 persons. Most outbreaks, 124 (76%) of those with a known water source (n = 163) were linked to groundwater. A large proportion of the outbreaks (n = 130/170, 76%) affected a small number of people (less than 100 per outbreak) and were linked to single-household water supplies. However, in 11 (6%) of the outbreaks, more than 1,000 people became ill. Although outbreaks of this size are rare, they highlight the need for increased awareness, particularly of parasites, correct water treatment regimens, and vigilant management and maintenance of the water supply and distribution systems.
In Vivo Tropism of Hepatitis C Virus Genomic Sequences in Hematopoietic Cells: Influence of Viral Load, Viral Genotype, and Cell Phenotype
Authors: Hervé Lerat, Sylvie Rumin, François Habersetzer, Françoise Berby, Mary-Anne Trabaud, Christian Trépo, Geneviève Inchauspé
Journal: Blood (1998)
CRISPR/Cas9-Mediated Correction of the Sickle Mutation in Human CD34+ cells
Authors: Megan D Hoban, Dianne Lumaquin, Caroline Y Kuo, Zulema Romero, Joseph Long, Michelle Ho, Courtney S Young, Michelle Mojadidi, Sorel Fitz-Gibbon, Aaron R Cooper, Georgia R Lill, Fabrizia Urbinati, Beatriz Campo-Fernandez, Carmen F Bjurstrom, Matteo Pellegrini, Roger P Hollis, Donald B Kohn
Journal: Molecular Therapy (2016)

Targeted genome editing technology can correct the sickle cell disease mutation of the β-globin gene in hematopoietic stem cells. This correction supports production of red blood cells that synthesize normal hemoglobin proteins. Here, we demonstrate that Transcription Activator-Like Effector Nucleases (TALENs) and the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 nuclease system can target DNA sequences around the sickle-cell mutation in the β-globin gene for site-specific cleavage and facilitate precise correction when a homologous donor template is codelivered. Several pairs of TALENs and multiple CRISPR guide RNAs were evaluated for both on-target and off-target cleavage rates. Delivery of the CRISPR/Cas9 components to CD34+ cells led to over 18% gene modification in vitro. Additionally, we demonstrate the correction of the sickle cell disease mutation in bone marrow derived CD34+ hematopoietic stem and progenitor cells from sickle cell disease patients, leading to the production of wild-type hemoglobin. These results demonstrate correction of the sickle mutation in patient-derived CD34+ cells using CRISPR/Cas9 technology. Targeted genome editing technology can correct the sickle cell disease mutation of the β-globin gene in hematopoietic stem cells. This correction supports production of red blood cells that synthesize normal hemoglobin proteins. Here, we demonstrate that Transcription Activator-Like Effector Nucleases (TALENs) and the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 nuclease system can target DNA sequences around the sickle-cell mutation in the β-globin gene for site-specific cleavage and facilitate precise correction when a homologous donor template is codelivered. Several pairs of TALENs and multiple CRISPR guide RNAs were evaluated for both on-target and off-target cleavage rates. Delivery of the CRISPR/Cas9 components to CD34+ cells led to over 18% gene modification in vitro. Additionally, we demonstrate the correction of the sickle cell disease mutation in bone marrow derived CD34+ hematopoietic stem and progenitor cells from sickle cell disease patients, leading to the production of wild-type hemoglobin. These results demonstrate correction of the sickle mutation in patient-derived CD34+ cells using CRISPR/Cas9 technology.
Coincidental detection of the first outbreak of carbapenemase-producing Klebsiella pneumoniae colonisation in a primary care hospital, Finland, 2013
Authors: M Kanerva, K Skogberg, K Ryynänen, A Pahkamäki, J Jalava, J Ollgren, E Tarkka, O Lyytikäinen
Journal: Eurosurveillance (2015)

In Finland, occurrence of Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-KP) has previously been sporadic and related to travel. We describe the first outbreak of colonisation with KPC-KP strain ST512; it affected nine patients in a 137-bed primary care hospital. The index case was detected by chance when a non-prescribed urine culture was taken from an asymptomatic patient with suprapubic urinary catheter in June 2013. Thereafter, all patients on the 38-bed ward were screened until two screening rounds were negative and extensive control measures were performed. Eight additional KPC-KP-carriers were found, and the highest prevalence of carriers on the ward was nine of 38. All other patients hospitalised on the outbreak ward between 1 May and 10 June and 101 former roommates of KPC-KP carriers since January had negative screening results. Two screening rounds on the hospital's other wards were negative. No link to travel abroad was detected. Compared with non-carriers, but without statistical significance, KPC-KP carriers were older (83 vs 76 years) and had more often received antimicrobial treatment within the three months before screening (9/9 vs 90/133). No clinical infections occurred during the six-month follow-up. Early detection, prompt control measures and repetitive screening were crucial in controlling the outbreak.
Poisonous Snakebite
Authors: Henry A. Plantier
Journal: New England Journal of Medicine (1963)

IN this day and age of science fairs, mail-order houses, family camping trips and extensive travel, the problem of snakebite is becoming more common. The patient described below was referred to the Boston Poison Information Center.Case ReportG.W. (B.F.H. 47960), a 16-year-old boy, was admitted to the Boston Floating Hospital with a history of snakebite 2 hours previously. He had been in good health until he was bitten by a Western diamondback rattlesnake he was caring for as part of a high-school science project. The single fang mark was on the distal phalanx of the 4th right finger, and . . .
Induction of RKIP and Inhibition of the Transcription Repressor YY1 in B-NHL by the Novel Proteasome Inhibitor NPI-0052 and Sensitization to TRAIL-Induced Apoptosis.
Authors: Eriko Suzuki, Sara Huerta-Yepez, Stavroula Baritaki, Michael Palladino, Benjamin Bonavida
Journal: Blood (2006)