tbuckley/cabot-search huggingface dataset:
Geriatric psychiatry training for the general psychiatric resident
Authors: S I Finkel
Journal: American Journal of Psychiatry (1978)

Although there is a real need in variety of settings for psychiatrists trained in working with older people, a large proportion of psychiatric residency programs do not offer the opportunity for clinical experience with this age group. The author stresses the need to include this subject in the curriculum of residency training programs. He describes the features of one program that offers comprehensive training in this area.
Hepatitis A in the European Union: responding to challenges related to new epidemiological patterns
Authors: L Payne, D Coulombier
Journal: Eurosurveillance (2009)

In the European Union (EU), the overall incidence of hepatitis A has decreased over the last 10 years from 15.1 per 100,000 population in 1996 to 3.9 per 100,000 in 2006. However, reduction in circulation of HAV leads to decreased acquisition of immunity and, in the absence of universal vaccination, an accumulation of susceptible individuals. The impact of increasing susceptibility of the general population on the risk for outbreaks is clearly illustrated in independent outbreaks in Czech Republic, Latvia and Slovakia in 2008, described in three of the articles published in this week’s issue of Eurosurveillance.
CR-24A 5-YEAR UPDATE REPORT OF A NATIONAL, VIRTUAL, INTERDISCIPLINARY ENDEAVOUR TO IMPROVE OUTCOMES FOR CHILDREN WITH HYPOTHALAMIC PITUITARY AXIS TUMOURS (HPATS) USING MULTI-SITE VIDEO CONFERENCING
Authors: Gloria Shir Wey Pang, Maria Michaelidou, Paul Morillon, Yen-Ching Chang, Joanne C. Blair, Benedetta Pettorini, Conor Mallucci, Barry Pizer, Ian Kamaly, Peter E. Clayton, Indraneel Banerjee, Darren Hargrave, Antony Michalski, Neil Dorward, Kristian Aquilina, Ash Ederies, Helen Spoudeas
Journal: Neuro-Oncology (2016)
First year of the thoracic triumvirate
Authors: Nicholas Hart, Gisli Jenkins, Alan Robert Smyth
Journal: Thorax (2016)

When we accepted the prestigious role of Joint Editors-in-Chief of Thorax 1 year ago we were fully aware of the enormous responsibility that came with the role as well as the challenges that we would face as the editorial team. We were wholly cognisant that we were representing more than just a journal, but indeed we were representing an important national body, the British Thoracic Society (BTS). Our key aims were to focus on originality, excellence and rigour in respiratory, sleep and critical care medicine to ensure that Thorax delivers interesting, educational and impactful content to all its readers, most importantly BTS members. We were tasked with building up still further the publication metrics. In the last year, our top read articles have included the pulmonary nodule guidelines,1 read over 9000 times and cited 17 times, original research looking at the use of venous blood gas analysis in COPD,2 read over 6700 times, clinical trial data from the Lebrikizumab trials,3 read over 5000 times and cited 16 times, basic science studies investigating the role of Toll-like receptor 7 in regulating …
A Small-Animal Analytical Respirometer&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Arnold W. Pratt
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article A Small-Animal Analytical Respirometer Get access Arnold W. Pratt Arnold W. Pratt Laboratory of Physiology, National Cancer Institute,4Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 1, January 1958, Pages 161–172, https://doi.org/10.1093/jnci/20.1.161 Published: 01 January 1958 Article history Received: 01 August 1957 Published: 01 January 1958
Reduced TSH and prolactin responses to TRH in patients with panic disorder
Authors: P P Roy-Byrne, T W Uhde, D R Rubinow, R M Post
Journal: American Journal of Psychiatry (1986)

The authors studied the TSH and prolactin responses to a standard 500-micrograms thyrotropin-releasing hormone (TRH) stimulation test in 12 patients with panic disorder and 10 control subjects. As a group, panic disorder patients had lower mean TSH and prolactin responses, and female patients accounted for the lower prolactin response. The clinical and theoretical implications of these findings are discussed.
PNR-01COMPLETE RESOLUTION OF A SUBTOTALLY RESECTED C19MC NEGATIVE EMBRYONAL TUMOR WITH MULTILAYERED ROSETTES (ETMR) USING HIGH DOSE CHEMOTHERAPY AND STEM CELL TRANSPLANT: CASE REPORT AND LITERATURE REVIEW OF C19MC POSITIVE AND NEGATIVE ETMR CASES
Authors: Mary Dougherty, Miguel Guzman, Thomas Geller, Lindsay Brefeld, Vilaas Shetty, Samer Elbabaa, Mohamed S. AbdelBaki
Journal: Neuro-Oncology (2016)
Profound neutropenia during the early phase of hemodialysis
Authors: L. S. Kaplow
Journal: JAMA (1968)

Patients undergoing hemodialysis manifest marked temporary neutropenia occurring 2 to 15 minutes after the start of dialysis, followed by an increase in band neutrophils. Total leukocyte counts return to near normal levels approximately one hour later. The phenomenon is not due to simple filtration of leukocytes by the dialyzer nor to heparin sodium administration, and is independent of the administration set or the infusion pump mechanism. Rebound leukocytosis is not observed, and the neutropenia is unaccompanied by chills, fever, or other symptoms usually associated with intravenous infusions of pyrogenic substances.
Competition and Health Care
Authors: Philip Caper
Journal: New England Journal of Medicine (1982)

The proposed "pro-competitive" overhaul of the ways in which health care is financed and delivered has sparked great interest and controversy among a wide range of participants in the health-care field. When first proposed, the notion of increasing competitive forces in the health-care field won broad support, since it promised to replace much existing regulation with a revised set of incentives. But as pro-competitive theory has assumed the more tangible form of legislation, it has become clearer to many groups of constituents that complex regulation will be necessary to make the proposals work properly, and that many of the specific . . .
18F-Florbetapir and 18F-FDG PET/CT in Systemic Immunoglobulin Light Chain Amyloidosis Involving the Peripheral Nerves
Authors: Stephen M. Broski, Robert J. Spinner, Benjamin M. Howe, Angela Dispenzieri, Geoffrey B. Johnson
Journal: Clinical Nuclear Medicine (2015)

We present a case of both F-FDG and F-florbetapir uptake in a biopsy-confirmed immunoglobulin light chain (AL) amyloidosis involving the peripheral nerves. AL amyloidosis is the most common cause of acquired amyloid polyneuropathy, manifesting with both sensorimotor and autonomic neuronal dysfunction. Given the overlapping MRI and FDG PET/CT appearances of several different causes of peripheral neuropathy, F-florbetapir PET/CT provides another potential tool in the imaging algorithm of these patients and may guide targeted fascicular biopsy for pathologic confirmation.
HG-114NEUTROPHIL LYMPHOCYTE COUNT RATIO (NLCR) IN PREDICTING THE HISTOLOGICAL GRADE OF PAEDIATRIC GLIAL TUMOURS
Authors: Fozia Saeed, Jamie Wilson, Paul Chumas
Journal: Neuro-Oncology (2016)

AbstractNeutrophil lymphocyte count ratio (NLCR) in predicting the histological grade of paediatric CNS tumours INTRODUCTION: Neutrophil Lymphocyte Count Ratio (NLCR) is an established prognostic marker for renal, lung and colorectal carcinomas, and has been suggested to be predictive of histological grade in adult intrinsic primary brain tumours. The purpose of this study was to determine the prognostic impact of pre-operative NLCR in paediatric CNS tumours, in view of disease specific survival and also the prognostic impact of pre-operative NLCR in paediatric CNS tumours stratified by intrinsic subtypes. METHODS: Retrospective analysis at a single centre. Patients less than 18 years old at the time of surgery who underwent tumour-related procedures from 2006–2015. Craniopharyngiomas, recurrent tumours, previous bone marrow transplants and metastases were excluded. Pre-operative NLCRs (collected before the diagnosis of intracranial pathology, and before administration of steroids) were matched with histological diagnosis for each patient. Post-operative NLCR was also recorded where possible. RESULTS: A total of 112 paediatric patients (71 males and 41 females) of an average age 8 ± 4 years, with a diagnosis of primary intrinsic CNS tumours had pre-operative NLCR that could be matched to final histological grade. WHO Grade 1 and 2 tumours (‘low grade’, n=53) had a mean NLCR of 2.42 (95% CI 1.81–3.02) compared to a mean NLCR of 3.56 (95% CI 2.73–4.79) for Grade 3 and 4 tumours (‘high grade’, n=59), which was statistically significant (p=0.035). One-way ANOVA showed a statistically significant variance for NLCR between each grade of tumour. The NLCR for Medulloblastoma was significantly higher (4.2) compared to the low grade cohort (2.42) which was statistically significant (p=0.006). Further analysis of the medullobalstomas showed NLCR for metastatic (n=8, 5.15) and non-metastatic (n=16, 4.9) tumours to have no difference between them (p=0.56). CONCLUSION: Our preliminary results are consistent with published literature on adult tumours and suggest that a larger pre-operative NLCR may correlate with a higher final histological grade in paediatric CNS tumours. Sub-group analysis showed that both metastatic and non-metastatic medulloblastomas have a significantly higher NLCR than low grade CNS tumours.
MB-52RESPONSE ASSESSMENT IN PEDIATRIC NEURO-ONCOLOGY (RAPNO) COMMITTEE GUIDELINES FOR RESPONSE ASSESSMENT IN MEDULLOBLASTOMA AND OTHER LEPTOMENINGEAL SEEDING TUMORS
Authors: Kathy Warren, Julie Harreld, Marc Chamberlain, Gilbert Vezina, Monika Warmuth-Metz, Katja von Hoff, Roger Packer, Alba Brandes, Moshe Reiss, Stewart Goldman, Michael Fisher, Tina Poussaint, Ian Pollack, Michael Prados, Patrick Wen, Susan Chang, Christelle Dufour, David Zurakowski, Rolf-Dieter Kortmann, Mark Kieran
Journal: Neuro-Oncology (2016)
Topical treatments for scalp psoriasis: summary of a Cochrane Systematic Review
Authors: J.G. Schlager, S. Rosumeck, R.N. Werner, A. Jacobs, J. Schmitt, C. Schlager, A. Nast
Journal: British Journal of Dermatology (2016)

People with chronic plaque psoriasis often have lesions on the scalp that are difficult to treat. This report is a summary of a Cochrane review on the efficacy and safety of topical treatments for scalp psoriasis. For quality-of-evidence assessment, we used the Grading of Recommendations Assessment, Development and Evaluation Working Group approach. Only randomized controlled trials (RCTs) were eligible for inclusion. We searched the Cochrane Skin Group Specialised Register, CENTRAL, MEDLINE, Embase and LILACS; ongoing trials; indexes of included studies and screened abstracts of six psoriasis-specific conferences up to August 2015. We included 59 RCTs, with 11 561 participants overall. Most findings were limited to short-term treatments (< 6 months). According to the clinician and patients' self-assessment, a corticosteroid-vitamin D combination (e.g. betamethasone dipropionate plus calcipotriol) and corticosteroids of high and very high potency were better than vitamin D. The two-compound combination was superior to the corticosteroid alone, but the additional benefit was small. Reporting of quality-of-life data was insufficient. The two-compound combination and corticosteroids caused fewer withdrawals due to adverse events than vitamin D. There was no difference between the two-compound combination and corticosteroid monotherapy concerning this outcome. Overall the evidence was of moderate quality. Evaluation of other topical treatments was limited. Given the comparable safety profile and only slim benefit of the two-compound combination over the corticosteroid alone, monotherapy with generic topical corticosteroids of high and very high potency may be fully acceptable for short-term therapy. More quality-of-life data and long-term assessments are needed.
&lt;emph type="ital"&gt;Landscape (Bayou)&lt;/emph&gt;
Authors: Janet M. Torpy
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Sustaining Relationships
Authors: Katharine Treadway
Journal: New England Journal of Medicine (2008)

The editors asked several experts to share their perspectives on the crisis in U.S. primary care. Their articles, which address this crisis from six different angles, follow. We also brought the five U.S. contributors together for a roundtable discussion of the problems and potential solutions for training, practice, compensation, and systemic change. A video of the discussion and reader comments can be seen at www.nejm.org."A growing chorus of discontent suggests that the once-revered doctor–patient relationship is on the rocks." New York Times, July 29, 2008With its combination of care for acute, undiagnosed illness and complex, multisystem disease, as well as the provision of extensive preventive care, all in the setting of a long relationship built on mutual trust and knowledge, primary care has long been a deeply rewarding profession. But in recent years, this once-extraordinary specialty has seen its ranks diminish as doctors struggle with an increasing amount of paperwork, the explosion of therapeutic options, and a dramatic expansion in preventive care responsibilities. . . .
Effect of perioperative myocardial infarction on survival of postcardiotomy patients supported with ventricular-assist devices.
Authors: Pennington Dg, McBride Lr, Kanter Kr, Swartz Mt, Lagunoff D, Palmer D, Martin T, Miller Lw
Journal: Circulation (1988)

Ventricular-assist devices (VAD) have increased survival in patients with postcardiotomy shock, but the predictors of success need to be elucidated. We evaluated 45 patients treated with centrifugal (n = 18) or pulsatile (n = 27) VAD for postcardiotomy cardiogenic shock to determine the effect of perioperative myocardial infarction (PMI) on survival. The patients ranged in age from 15 to 72 years (mean age, 55.1 years). VAD support was left ventricular in 29, right ventricular in seven, and biventricular in nine, and the flow-rate range was 1.6-5.2 l/min (mean rate, 3.97 l/min) for 0.2-22 days (mean time, 4.1 days). PMI was determined by analysis of postoperative electrocardiogram (EKG), enzyme levels, or at necropsy. PMI was considered  if there were either EKG or enzyme level changes, and  if there were EKG and enzyme level changes or necropsy evidence. Of the 45 patients, 19 were successfully weaned from ventricular assistance; 12 were discharged (Group 1), and seven died (Group 2); the remaining 26 patients could not be weaned from VAD support (Group 3). In Group 1, one patient had a definite PMI, and three had a possible PMI. Among the 33 nonsurvivors (Groups 2 and 3), 24 patients had PMI by necropsy examination. Definite PMI was much more common in nonsurvivors (72.7%) than in survivors (8.3%) (p less than 0.05). However, Group 2 nonsurvivors were weaned despite PMI in 100% of cases. These data suggest that, although PMI is a strong negative determinant of survival in postcardiotomy patients, it cannot be considered a contraindication because it does not preclude myocardial recovery.
Biologic Characteristics of Nonpalpable, Nonsymptomatic, Solitary Polyps of the Rectum
Authors: M ORTMAYER
Journal: JNCI Journal of the National Cancer Institute (1947)

Biologic Characteristics of Nonpalpable, Nonsymptomatic, Solitary Polyps of the Rectum Get access Marie Ortmayer, M. D. Marie Ortmayer, M. D. Women and Children's Hospital, Chicago Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 5, April 1947, Pages 387–391, https://doi.org/10.1093/jnci/7.5.387 Published: 01 April 1947
<i>Notes from the Field:</i>Typhoid Fever Outbreak Associated with an Asymptomatic Carrier at a Restaurant ― Weld County, Colorado, 2015
Authors: Jessica Hancock-Allen, Alicia B Cronquist, JoRene Peden, Debra Adamson, Nereida Corral, Kerri Brown
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

On September 11, 2015, a single case of typhoid fever, caused by Salmonella Typhi infection, was reported to the Colorado Department of Public Health and Environment (CDPHE). Because the patient (patient A) had symptom onset September 2 and had traveled internationally for 4 days 60 days before symptom onset, the case initially was thought to be travel-associated* (1,2). On October 1, a second case of S. Typhi infection was reported in patient B, with symptom onset September 20. Patient B reported no international travel or contact with ill persons or known carriers. Patients A and B resided approximately 6 miles (10 kilometers) apart and had no discernible epidemiologic connection. Family members of patients A and B tested negative for S. Typhi. CDPHE and the Weld County Department of Public Health and Environment (WCDPHE) investigated to 1) determine whether these cases represented a larger outbreak, 2) identify common exposure sources, and 3) stop transmission. Investigators determined that the typhoid fever in both patients and in a third patient (patient C) was associated with eating in the same restaurant during a 5-day period.
Genome-Wide Analysis of DNA Methylation and Cigarette Smoking in a Chinese Population
Authors: Xiaoyan Zhu, Jun Li, Siyun Deng, Kuai Yu, Xuezhen Liu, Qifei Deng, Huizhen Sun, Xiaomin Zhang, Meian He, Huan Guo, Weihong Chen, Jing Yuan, Bing Zhang, Dan Kuang, Xiaosheng He, Yansen Bai, Xu Han, Bing Liu, Xiaoliang Li, Liangle Yang, Haijing Jiang, Yizhi Zhang, Jie Hu, Longxian Cheng, Xiaoting Luo, Wenhua Mei, Zhiming Zhou, Shunchang Sun, Liyun Zhang, Chuanyao Liu, Yanjun Guo, Zhihong Zhang, Frank B. Hu, Liming Liang, Tangchun Wu
Journal: Environmental Health Perspectives (2016)

Smoking is a risk factor for many human diseases. DNA methylation has been related to smoking, but genome-wide methylation data for smoking in Chinese populations is limited.We aimed to investigate epigenome-wide methylation in relation to smoking in a Chinese population.We measured the methylation levels at > 485,000 CpG sites (CpGs) in DNA from leukocytes using a methylation array and conducted a genome-wide meta-analysis of DNA methylation and smoking in a total of 596 Chinese participants. We further evaluated the associations of smoking-related CpGs with internal polycyclic aromatic hydrocarbon (PAH) biomarkers and their correlations with the expression of corresponding genes.We identified 318 CpGs whose methylation levels were associated with smoking at a genome-wide significance level (false discovery rate < 0.05), among which 161 CpGs annotated to 123 genes were not associated with smoking in recent studies of Europeans and African Americans. Of these smoking-related CpGs, methylation levels at 80 CpGs showed significant correlations with the expression of corresponding genes (including RUNX3, IL6R, PTAFR, ANKRD11, CEP135 and CDH23), and methylation at 15 CpGs was significantly associated with urinary 2-hydroxynaphthalene, the most representative internal monohydroxy-PAH biomarker for smoking.We identified DNA methylation markers associated with smoking in a Chinese population, including some markers that were also correlated with gene expression. Exposure to naphthalene, a byproduct of tobacco smoke, may contribute to smoking-related methylation.Zhu X, Li J, Deng S, Yu K, Liu X, Deng Q, Sun H, Zhang X, He M, Guo H, Chen W, Yuan J, Zhang B, Kuang D, He X, Bai Y, Han X, Liu B, Li X, Yang L, Jiang H, Zhang Y, Hu J, Cheng L, Luo X, Mei W, Zhou Z, Sun S, Zhang L, Liu C, Guo Y, Zhang Z, Hu FB, Liang L, Wu T. 2016. Genome-wide analysis of DNA methylation and cigarette smoking in Chinese. Environ Health Perspect 124:966-973; http://dx.doi.org/10.1289/ehp.1509834.
Subserosal recurrence without mucosal involvement diagnosed 5 years after endoscopic submucosal dissection for early rectal cancer
Authors: Sung Bae, Woon Jeong, Ok Bae, Seong Baek
Journal: Endoscopy (2015)

A 61-year-old woman underwent successful en bloc endoscopic submucosal dissection (ESD) for the management of a 4-cm, nodular, mixed-type, laterally spreading tumor located 11 cm from the anal verge ([Fig. 1]). Although the depth of submucosal invasion was 3000 μm, the patient refused additional surgical treatment. Three weeks after ESD, the patient developed an extraperitoneal pelvic abscess, which was caused by delayed rectal perforation and required percutaneous drainage.
HG-105DEFORMATIONAL CHANGES IN THE HUMAN BRAIN STEM FROM CONVECTION ENHANCED DELIVERY (CED)
Authors: Karima Tizi, Eva Wembacher, Rowena Thomson, Maria Donzelli, Elizabeth Vaconcellos, Mark Souweidane
Journal: Neuro-Oncology (2016)

HG-105. DEFORMATIONAL CHANGES IN THE HUMAN BRAIN STEM FROM CONVECTION ENHANCED DELIVERY (CED) Karima Tizi1, Eva Wembacher3, Rowena Thomson3, Maria Donzelli2, Elizabeth Vaconcellos3, and Mark Souweidane1,2; Weill Cornell Medical College, New York, NY, USA; Memorial Sloan Kettering Cancer Center, New York, NY, USA; BrainLab, Munich, Germany INTRODUCTION: Preclinical work using CED has minimized concerns regarding conformational alterations in the brain. There has been no volumetric assessments however in humans undergoing CED. As part of an ongoing Phase 1 clinical trial using CED for children with DIPG, we sought to measure any treatment-related volumetric alterations in the human brain stem. METHODS: Volumetric measurements were performed using the pretreatment baseline and the firstpost-treatment MRI scans. An automatedalgorithm based on standard anatomical landmarks and post processing manual correction was used for 3-dimensional rendering of the brain stem. These measurements were longitudinally determined and reported as a percent change. Results were correlated with the assigned dose level and hence infusion volume. RESULTS: Brain stem volumetric assessments were performed in six patients (mean age 1⁄4 9.98 years) treated on two different dose levels (mean infusate volume 1⁄4 2.58 ml and 3.54 ml). At the lower dose level the mean pre-treatment brain stem volumes 1⁄4 45.5 cm3, mean post-treatment volumes 1⁄4 46.3 cm3, and the mean DV 1⁄4 0.876 cm3 (SD 1.74) (2%). At the higher dose level the mean pre-treatment volumes 1⁄4 35.1 cm3, mean posttreatment volumes 1⁄4 39.2 cm3, and the mean DV 1⁄4 4.017 cm3 (SD 1.6) (11.8%). CONCLUSION: CED for children with DIPG results in deformational changes of the brain stem. These volumetric alterations are dosedependent and may have implications in assessment of disease response. Correlation of such volumetric alterations with clinical tolerance may help design future clinical trials that employ CED in the brain stem. Neuro-Oncology 18:iii48–iii77, 2016. doi:10.1093/neuonc/now073.101 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.