SAT0295 Measuring Microarchitecture Bone in Patients with Systemic Lupus Erythematosus. Pilot Study
Authors: N. Mena-Vazquez, M. Rojas-Giménez, C.M. Romero-Barco, S. Manrique-Arija, M.C. Ordόñez-Cañizares, C. Domic, C. Fuego, V. Rodríguez-García, F.G. Jiménez-Núñez, I. Ureña-Garnica, L. Cano-García, M.V. Irigoyen-Oyarzabal, M. Rodríguez-Pérez, A. Fernández-Nebro
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To evaluate the trabecular bone score (TBS) in patients with systemic lupus erythematosus (SLE). <h3>Methods</h3> Design: Cross sectional study. Patients: we recruited 37 patients with SLE who had at least one DXA and one analysis of the trabecular microarchitecture during the follow-up. Protocol: we analysed the most recent DXA, TBS and clinical data collected from the clinical records using a predesigned questionnaire. Variables: demographic, therapeutic (including use of glucocorticoids and antiresorptives), clinical and laboratory features of SLE (including cumulative number of ACR criteria of LES, SLICC damage and SELENA-SLEDAI average of the two years prior at protocol date). Also were collected: personal and family history of fragility fractures, densitometric diagnosis (OMS) and FRAX index. Outcome variables: (1) Measurement of microarchitecture using software "Trabecular bone score -MedIMaps®" (TBS) and (2) Measurement of BMD (g/cm<sup>2</sup>) of the lumbar spine (L1 L4), proximal femur and total hip, using DXA (GE Lunar Prodigy Advance). Definitions: The cutoff points for TBS used in the study were the same proposed by the International working group of TBS users: (1) Normal microarchitecture, score&gt;1.350; (2) microarchitecture partially degraded, score &lt;1.350 and &gt;1.200; and (3) microarchitecture degraded&lt;1.200. Bone densitometry scores were classified according to OMS criteria as normal bone, osteopenia and osteoporosis at the lumbar spine (LS), femoral neck (FN) and total hip (TH). Statistical analysis: Descriptive analysis of the main variables, T-student test for the comparison of quantitative variables of groups, Fisher exact test to compare qualitative and correlation of Pearson/Spearman Rho for the quantitative variables. <h3>Results</h3> The main characteristics of the patients (n=37) are shown in the Table. Almost all of them had received hydroxychloroquine, calcium supplements and vitamin D. The majority had lumbar osteopenia (43.9%) and trabecular bone microarchitecture partially degraded (46.3%). A trend towards association between densitometric diagnosis (OMS) and the TBS LS (p=0.096) was observed, but not in the case of the BMD FN (p=0.335) or BMD TH (p=0.447).) A negative correlation between the FRAX index and the LS T-score (p=0005 r= -0.5) and FN (r= -0.7; p&lt;0.001 was observed, but not with the TBS (Rho = -0, 3; p=0.1). No correlation between FRAX, TBS, SLEDAI and SLICC was observed. No association was observed between the uses of hydroxychloroquine, oral or intravenous glucocorticoids and the T-score or TBS. <h3>Conclusions</h3> Most patients with SLE studied in this small pilot study have some moderate bone disorder that affects both the amount of bone mass and quality of their lumbar trabecular microarchitecture. <h3>Acknowledgements</h3> SEIOMM <h3>Disclosure of Interest</h3> None declared