tbuckley/cabot-search huggingface dataset:
OP0220 Pathogenic Role of IL-10 Producing Helper T Cells in Systemic Lupus Erythematosus
Authors: F. Facciotti, A.E. Penatti, S. Zeni, S. Abrignani, P. Meroni, J. Geginat
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> IL-10 is a potent anti-inflammatory cytokine that contributes to the suppressive functions of regulatory T-cells, but it is also a well-known B cell growth and differentiation factor produced by CD4+ helper T-cells. Consequently, IL-10 is pathogenic in systemic lupus erythematosus (SLE) where it promotes autoantibody production and nephritis. We have previously shown that human CCR6+ memory T cells produce IL-10 in secondary lymphoid organs, and more recently we found that they promote B cell antibody production via IL-10, but are distinct from follicular helper (T<sub>FH</sub>) and Th17 cells. <h3>Objectives</h3> To monitor the frequency and function of IL-10-producing B helper T cells in SLE patients and to evaluate their association with disease activity. <h3>Methods</h3> Blood samples from 40 clinically well-characterized SLE patients and 25 healthy donors (HD) were included. Composition of different T cell subsets in peripheral blood according to surface markers expression and intracellular cytokine production were assessed by flow cytometry. The frequencies of T cell subsets were correlated with disease activity (measured by the SELENA-SLEDAI index). To assess B helper functions, T cell subsets and B cells from SLE patients and HD were co-cultured ex vivo and IgG production was measured in supernatants by ELISA. <h3>Results</h3> IL10-producing CCR6+ memory T cells, but not T<sub>FH</sub> cells were significantly expanded in the peripheral blood of SLE patients as compared to HD. Importantly, the frequency of CCR6+ memory T cells and serum levels of IL-10, but not of IL-17, correlated with disease activity. Ex vivo sorted CCR6+ helper T cells from blood of SLE patients produced high levels of IL-10 upon co-culture with B cells and promoted IgG production. Strikingly, CD25+ Tregs suppressed B cell help provided by CCR6+ T cells in HD, but not in SLE patients. <h3>Conclusions</h3> Our results demonstrated that accumulation of IL-10-producing CCR6+CD4+ memory T cells correlates with SLE disease activity, supporting a pathogenic role of these helper T cells.This hypothesis is corroborated by functional experiments, which demonstrate a Treg-resistant B helper capacity of IL-10-producing CCR6+ T cells in SLE patients. Therefore, CCR6+IL10-producing helper T cells represent a potential therapeutic target and/or diagnostic/prognostic marker of disease activity in SLE patients. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5485
CORRELATES AND IMPACT OF CORONARY ARTERY CALCIFICATION VISUALIZED BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Yash Singbal, Yuliya Vengrenyuk, Takahiro Yoshimura, Usman Baber, Jacobo Pena, Roja Thapi, Jason Kovacic, Joseph Sweeny, Srinivas Kesanakurthy, Choudhury Hasan, Jagat Narula, Samin Sharma, Annapoorna Kini
Journal: Journal of the American College of Cardiology (2016)
PTU-146 Incidence and Predictors of Eosinophilic Oesophagitis in Dysphagia: A Prospective Analysis
Authors: I A Murray, S Bennett, J Palmer, M Lau, M Schultz
Journal: Gut (2013)

<h3>Introduction</h3> Eosinophilic oesophagitis (EO) causes dysphagia: 10–15% in European and US studies. It is diagnosed by finding &gt; 20 eosinophils per hpf in oesophageal biopsies. We prospectively examined the incidence and clinical indicators of EO in a New Zealand population. <h3>Methods</h3> Interim analysis of demographics, symptoms and associated diseases by questionnaire prior to endoscopy in 75 consecutive patients with dysphagia. Endoscopic findings were recorded with histology. An initial analysis was performed to investigate whether age and gender of patients and symptoms (duration of dysphagia, intermittent or progressive symptoms, level of dysphagia, weight loss, choking, reflux odynophagia or a history of allergy) were associated with a final diagnosis of EO using chi squared or Fisher’s exact test as appropriate then logistic regression used to determine the final model. The sensitivity and specificity of endoscopic changes (furrows, ridges and rings) was determined separately and significance determined by Fisher’s exact test. Statistical significance was taken as P &lt; 0.05. Ethics approval was obtained. <h3>Results</h3> 75 patients, mean age 56 (range 15–94 years), 31 male (41%), had gastroscopy because of dysphagia. 64 (85.3%) completed the questionnaire and 67 (89.3%) had endoscopic biopsies. 12 (16%) had EO, mean age 36.7 years (range 18–62), 8 male. Endoscopic abnormalities suggestive of EO were seen in 7 EO patients (sensitivity 38.9%, specificity 91.2%: P &lt; 0.01). Allergy/atopy (hayfever, asthma, eczema, coeliac) was no more common in EO (54.5%) than those without (49.0%). The level of dysphagia was not pharyngeal in 5 EO patients. Duration of dysphagia was at least 6 months in all bar one EO patient (range 26 – 1248 weeks). Weight loss of 7–10 kg was reported by 4 EO patients. No patient responding to PPI therapy had EO. The strongest predictor of EO was age under 50 (OR 20.0 95% CI 3.4–117.8) with male sex also being significant (OR 6.7 95% CI 1.4–32.3). No other factor was statistically significant. <h3>Conclusion</h3> EO is present in a dysphagic New Zealand population with a relatively high incidence. It is more common in younger males but there was no obvious association with allergy. Although endoscopic changes associated with EO were highly specific they were not sufficiently sensitive to depend upon. We would recommend oesophageal biopsies in all patients presenting with dysphagia without obvious cause at endoscopy. <h3>Disclosure of Interest</h3> None Declared
PET/US Fusion as a Problem-Solving Tool in Oncology Imaging
Authors: Robert Drescher, Martin Freesmeyer
Journal: Clinical Nuclear Medicine (2013)

PET/CT is an established modality for evaluation of malignant disease. However, in many cases, specificity is impaired by false-positive findings. Recognition of these cases is crucial for correct diagnosis and subsequent patient management. In the presented case, malignant disease was suspected in a young man because of a history of B symptoms. F-FDG PET/CT showed hypermetabolic foci in both inguinal regions initially classified as possible lymphoma. Using a novel technique for PET/US fusion, ultrasound and PET were coregistered to clarify that PET hypermetabolism was due to a foreign body reaction after plug hernioplasty performed several years earlier.
AB0502 All-Cause Hospitalizations in Systemic Lupus Erythematosus from A Northern Italian Referral Centre
Authors: A. Bortoluzzi, M. Padovan, E. De Stefani, M. Govoni
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic disease with a variable course. Although the mortality rate has been reduced in the last decades, the clinical management of lupus patients is extremely complex and affected by morbidities, directly or indirectly, related to the disease. <h3>Objectives</h3> To estimate the rate of hospitalization in a cohort of patients with SLE from a Hub and Spoke referral centre in a Northern Italian district. To determine morbidity and mortality in this retrospective cohort of hospitalized SLE patients. <h3>Methods</h3> A retrospective analysis of all hospitalizations was done using the discharge ICD-9-MC coding system to identify all patients admitted with a diagnosis of SLE between January 1999 and December 2011 (12 years). <h3>Results</h3> After the retrospective chart review we included 366 patients for a total of 1051 admissions recorded in a time interval of 11 years. The mean age of patients at the time of hospitalization was 52.5 years (17.2 ±SD), 88.5% of patients were female. The most common reason of hospitalization, recorded in 51.9% of cases, was due to a disease related flare (at the onset or during the course of the same). The major comorbidities and complications reported were the following: cardiovascular (15.9%), haematological (9.7%), infectious (9.2%), renal (6.8%), neurological (5.9%). Hospitalizations associated with the coexistence of malignancies were reported in 7.6% of the cases, benign in 27/80 (33.7%). The mean hospitalization length was 11.4 days (11 ±SD). The annual rate of mortality was estimated as between 3% and 9% per year. <h3>Conclusions</h3> In this retrospective study SLE flares remain the main reason for hospitalization. This is aligned to what literature reports (range 11.8 - 80.8%). The proportion of cardiovascular diseases represents the most prevalent complication recorded with heavy increase in the cost of illness and public spending. Considering the relative young age of our population, this finding emphasizes the need for greater attention to this complication in the management of lupus patient in early stages of disease. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4904
Abstract 3861: Bladder cancer-associated gene expression signatures identified by profiling of exfoliated urothelia
Authors: Charles J. Rosser, Virginia Urquidi, Li Liu, Yijun Sun, Bryant Whiting, Patrick Villicana, Steve Goodison
Journal: Cancer Research (2011)

Abstract PURPOSE: Bladder cancer is the fifth most commonly diagnosed malignancy in the United States and one of the most prevalent worldwide. It harbors a probability of recurrence of &amp;gt;50%; thus, rigorous, long-term surveillance of patients is advocated. Flexible cystoscopy coupled with voided urine cytology is the primary diagnostic approach, but cystoscopy is an uncomfortable, invasive procedure and the sensitivity of voided urine cytology is poor in all but high-grade tumors. We sought to define a robust genetic signature that can be used to diagnose bladder cancer in a non-invasive manner. METHODS: Gene expression microarrays were utilized to analyze the transcript profiles of 52 urine samples from subjects with bladder tumors and 40 subjects without bladder tumors (cohort I). Data from microarrays containing 56,000 targets were subjected to a panel of statistical analyses to identify bladder cancer-associated gene signatures. Hierarchical clustering and supervised learning algorithms were used to classify samples on the basis of tumor burden. Furthermore, supervised machine learning and a cross-validation approach were used to build a 40-gene molecular classifier which was then validated in voided urine samples by quantitative PCR (qPCR) in an independent group of patients (cohort II – 46 subjects with bladder cancer and 37 subjects without bladder cancer). RESULTS: Hierarchical clustering classified normal urothelium and bladder cancer with 84% accuracy. A genetic profile consisting of 40 probes was identified in those patients (cohort I) with bladder cancer. In an independent experiment, 14 of the 40 genes indentified above were validated in voided urine samples by qPCR in cohort II. Utilizing this 14 gene signature, the diagnostic accuracy of detecting bladder cancer was 81%. CONCLUSION: Our results show that it is possible to achieve the detection of bladder cancer using molecular signatures present in exfoliated tumor urothelia. Further investigation and validation of the cancer-associated profiles in a diverse cohort may reveal important biomarkers for the detection and surveillance of bladder cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3861. doi:10.1158/1538-7445.AM2011-3861
PARE0008 Understanding the barbarian words of rheumatoid arthritis
Authors: S. Trope Chirol, G. Thibaud, G. Kobelt
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The evolution of the doctor-patient relationship allows the patient to be more active in its disease management. This mutation is found in rheumatology including patient education and self-assessment of the activity of rheumatoid arthritis (RA). <h3>Objectives</h3> The aim of this work was to enable patients to better understand the terms used by the different stakeholders to facilitate communication and allow them to be more involved. <h3>Methods</h3> The patients Association ANDAR brought together people affected by RA and a committee of rheumatology experts to collectively determine which terms should be explain, to develop definitions and choose the medium, in collaboration with the association and communication agency. <h3>Results</h3> The working group has listed 195 words or phrases classified into 6 areas: my joints, my illness, my exams, my treatment team, my treatments, my rights. The work took the form of an interactive pdf file, offering different levels of entry: by lexicon or area. A single click returns to the page offering the definition. The group chose a humorous tone for the design, introductions and illustrations, keeping definitions and explanations on a more sober tone. <h3>Conclusions</h3> the support thus created can be viewed and downloaded on the website of the association but also sent in a simple email. This format allows a wide distribution and free access to any patient interested in understanding the words in connection with its PR. <h3>Acknowledgements</h3> Pr. Bruno Fautrel, Dr. Laure Gossec, Dr. Jeremie Sellam, EmPatient Agency This work was supported by Roche <h3>Disclosure of Interest</h3> None Declared
P15.15 * QUALITY OF LIFE AND POSTOPERATIVE REHABILITATION IN PATIENTS WITH CEREBRAL GLIOMAS
Authors: V. Rozumenko, A. Khoroshun, A. Rozumenko
Journal: Neuro-Oncology (2014)

BACKGROUND: The rehabilitation of oncological patients is a very important medico-social problem. A crucial question of neurooncology is postoperative recovery treatment of patients with neurological deficit. AIM AND METHODS: Comparative analysis of clinical signs in pre- and postoperative periods was performed in 210 patients with cerebral gliomas. RESULTS: We defined thirty main factors that determinate the social and adaptative factors of quality of life. Recovering treatment in early postoperative period patients with gliomas included medication (vasoactive and anticholinergetic drugs), physiotherapeutical methods (laser-therapy, electrostimulation), massage and medical gymnastic. The physiological approach of recovering treatment gave a posibility to individualize the treatment and furthers psychological adaptation after operation and rises the quality of life. For optimization of physiotherapeutical methods the patient general condition, tumor grade, functional status and accompanied diseases were taken into account. The results of treatment were estimated according to the quality of life scale. CONCLUSION: The use of differentiated rehabilitation treatment in early postoperative period helps to improve the results of surgical treatment and provides high quality of live of patients with cerebral gliomas.
Complete pancreas divisum with patulous minor papilla complicated by multifocal branch-duct intraductal papillary mucinous neoplasms
Authors: Y. Nakagawa, M. Yamauchi, R. Ogawa, M. Watada, K. Mizukami, T. Okimoto, M. Kodama, K. Murakami, T. Fujioka
Journal: Endoscopy (2013)

A 70-year-old Japanese woman who did not drink alcohol was admitted for investigation into the cause of her recurrent acute pancreatitis. On admission, an abdominal computed tomography (CT) scan revealed dilatation of the dorsal pancreatic duct and multifocal branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) that had enlarged relative to images that had been taken 3 years previously ([Fig. 1]). Magnetic resonance cholangiopancreatography (MRCP) also showed multifocal BD-IPMNs ([Fig. 2 a]) but could not detect the duct of Wirsung ([Fig. 2 b]). The largest cyst of the BD-IPMNs was < 3 cm and without mural nodules.
When I use a word . . .: Hepatojugular reflux
Authors: J. Aronson
Journal: BMJ (1999)

When several of the medical students, during a clinical assessment, told me that they were eliciting the hepatojugular reflex I began to wonder if I had it wrong. It is true that they weren’t able to tell me what the relevant reflex arc might be, and one of them even told me that the idea that blood could be made to flow back—that is, reflux—through the venous circulation simply by pressing on the liver was too simple an explanation (he’ll make a good physician). But no, I looked it up, and there it is, first described by W Pasteur in a short article in the Lancet (1885;ii:524). He thought that it was specific for tricuspid regurgitation, but it has turned out not to be. The best modern description of the sign and its history, including how to elicit and interpret it properly, is by Joseph D Sapira.1

The term reflux in relation to blood flow has a long pedigree. Not surprisingly, it was first used by William Harvey in 1653, in his Anatomical Exercises Concerning the Motion of the Heart and Blood, to describe the return of blood to the ears—that is, auricles—of the heart, although it does not seem to have been used to describe reflux through an incompetent cardiac valve until 1899, when it appeared in Thomas Allbutt’s multiauthored A System of Medicine (vol VI). Gastrointestinal—for example, oesophageal—reflux is very much a twentieth century idea. In contrast, “regurgitation” was already in use in a gastrointestinal sense by the start of the seventeenth century and only much later came to be used in reference to the heart.

So where did the students get the idea that hepatojugular reflux is a reflex. Well, my colleague Sonya Abrahams and I looked into it, and it turns out that hepatojugular reflux is called “the hepatojugular reflex” in several recent textbooks on clinical examination that I presume the students use.2-5 It is, of course, easy for authors to miss a typographical or copyediting error of this type; in another book, for example, the term is given correctly in the text but wrongly in the index. No doubt these misprints will be corrected in subsequent editions.
PTH-017 Strategy for Colorectal Cancer (CRC) Screening in Individuals with Significant Co-Morbid Conditions
Authors: R Ramaraj, R Dixon, H Adams, S Dolwani
Journal: Gut (2013)

<h3>Introduction</h3> With the advent of the Bowel cancer screening programme (BCSP) in the UK participants who have positive FOB tests are generally offered optical colonoscopy (OC) if considered safe, for early detection and prevention of CRC. In our study we undertook Computed Tomographic Colonography (CTC) in our hospital as the investigation of choice in those FOBt positive individuals with an American Society of Anesthesiology (ASA)grade &gt; = 3 and analysed outcomes. <h3>Methods</h3> Cases were prospectively discussed with screening practitioners carrying out assessments prior to OC and on the basis of hospital records and liaison with primary care physicians were assigned to CTC/OC with majority proceeding to OC as per standard practise. Patient data was accessed from our database in radiology, endoscopy and histology retrospectively and ASA grade assigned on the basis of the above information.44/69 cases that were referred for CTC from the BCSP between Feb 2009 and Nov 2011, were considered to have an ASA &gt; = 3.CTC results were analysed and correlated with endoscopic and histological findings. <h3>Results</h3> Out of 44 cases (17 female,27 male, mean age 65.4) with positive FOBt referred for CTC in the BCSP,50%(22) of patients had positive findings i.e.18 polyps and 4 suspected CRC.3/44 cases had a normal Flexible Sigmoidoscopy (FS) before CTC. Hence 41 of the above were considered to have had a primary CTC.44% (18/41) of patients referred for primary CTC had an endoscopy (20% OC,24% FS), of which 61% had a polypectomy.41 primary CTCs detected 32 polyps in 18 cases and 4 cancers.18 cases (4 diminutive polyps on CTC not requiring OC/FS) underwent endoscopy as a result of the above (OC 8, FS 10) detecting 36 polyps (35 removed) in 11 patients.86% of polyps were detected on the left side and the majority of this (83%) were histologically confirmed to be adenomas. In addition to this 2 left sided cancers was confirmed endoscopically. <h3>Conclusion</h3> In this small cohort CTC seems comparable to colonoscopy for detection of polyps and cancers1.In the patient group selected almost 44% of cases thought to have significant comorbidity who had primary CTC ended up having a lower GI endoscopy along with a need for therapy. It is also noted that the majority of significant polyps and all cancers were located in the left colon. We suggest that in this group a larger study evaluating a combination of CTC with FS (with no or minimal sedation) would be most appropriate in the context of the BCSP. It may also be useful to have evidence based criteria on fitness for colonoscopy in order to inform individuals and programmes on the appropriateness of screening in the context of comorbidity and the risk to benefit ratio. <h3>Disclosure of Interest</h3> None Declared. <h3>Reference</h3> Laghi, A <i>et al</i>. Current status on performance of CTC and clinical indications. EJR.doi:10.1016/j.ejrad.2012.05.026
Abstract 4493: Serum X-linked inhibitor of apoptosis protein (XIAP) predictive recurrence of renal cell carcinoma
Authors: Fumiya Hongo, Natsuki Takaha, Yasunori Kimura, Terukazu Nakamura, kazuya Mikami, Tsuneharu Miki
Journal: Cancer Research (2012)

Abstract Purpose: The X-linked Inhibitor of Apoptosis (XIAP) is associated with cell survival by blocking caspase-mediated apoptosis. The expression and prognostic significance of XIAP in renal cell cancer (RCC) has been rarely studied. To our knowledge, no report on the serum XIAP levels from RCC patients has been published. In this study, we examined serum XIAP levels of RCC patients and normal individuals and evaluated its utility as biomarker. Methods: Peripheral blood samples were obtained from 84 patients (59 men and 25 women, median age; 63 years [36-85]) with RCC before surgery. All the patients underwent radical or partial nephrectomy. Blood samples were also collected from 52 healthy controls. The serum TRAIL levels were measured by a sandwich enzyme-linked immunosorbent assay (Gencompare, TiterZyme®). Cut off value was calculated by ROC analysis. Results: The serum XIAP levels in patients with RCC were higher than those of normal control individuals (328.3 pg/ml vs 156.2 pg/ml, P&amp;lt;0.001). The progression free survival rate of the RCC patients with high serum XIAP was shown to be significantly lower than that of those with low serum XIAP in Grade 1-2 group (P &amp;lt; 0.05). Conclusions: Serum XIAP level is higher in renal cell cancers compared to normal control. High XIAP expression is not directly associated with tumor stage. These results suggest that it may be used as a novel prognosticator and a potential target for renal cell cancer diagnosis and therapy. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4493. doi:1538-7445.AM2012-4493
IMPACT OF POTENT P2Y12 INHIBITOR USE VERSUS CLOPIDOGREL IN REAL-WORLD PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: RESULTS FROM A LARGE SINGLE-CENTER REGISTRY
Authors: Raman Sharma, Usman Baber, Melissa Aquino, Jason Kovacic, Joseph Sweeny, Pooja Vijay, Srushti Shah, George Dangas, Roxana Mehran, Annapoorna Kini, Samin Sharma
Journal: Journal of the American College of Cardiology (2016)
Traumatic Thoracic Thecal Sac Laceration, Leak, and Pleural Effusion Diagnosed by Radionuclide Cisternogram
Authors: MICHAEL E. SPIETH, DARCY L. KASNER
Journal: Clinical Nuclear Medicine (2002)

From the Department of Radiology, Nuclear Medicine Section,* Marshfield Clinic, and Marshfield Medical Research and Education Foundation,† Marshfield, Wisconsin Received for publication October 1, 2001. Revision accepted February 19, 2002. Reprint requests: Michael E. Spieth, Department of Radiology, Marshfield Clinic, 1000 North Oak Avenue, Marshfield, Wisconsin 54449. E-mail: [email protected]