tbuckley/cabot-search huggingface dataset:
Peripherally Inserted Central Catheters vs Peripheral Cannulas for Delivering Parenteral Nutrition in Neonates
Authors: Sean B. Ainsworth, William McGuire
Journal: JAMA (2016)

Is parenteral nutrition via peripherally inserted central catheters (PICCs) associated with better delivery of nutrition and growth and fewer adverse events compared with short peripheral cannulas in neonates?Compared with short peripheral cannulas, parenteral nutrition via PICCs is associated with better nutrient delivery and lower rates of subsequent catheters or cannulas placed and is not associated with increased rates of invasive infection.
Delivery of neoadjuvant chemoradiation for patients with stage II and III rectal cancer is suboptimal
Authors: Mary Kay Barton
Journal: CA A Cancer Journal for Clinicians (2016)

Key Points The use of guideline‐recommended therapy of neoadjuvant chemoradiation and surgery for patients with rectal cancer has increased over the past decade, but nevertheless only 55% of patients received such treatment. Being of nonwhite race or Hispanic ethnicity, lacking private insurance, and living in an area with low aggregate educational levels were associated with a lower probability of receiving trimodality therapy.
SYD985, a novel HER2-targeting antibody-drug conjugate in preclinical models for USC, both in vitro and in vivo.
Authors: Jonathan Black, Salvatore Lopez, Emiliano Cocco, Stefania Bellone, Elena Bonazzoli, Carlton Schwab, Diana Peta-gay English, Peter J. Goedings, Patrick Beusker, Miranda van der Lee, Marco Timmers, Wim Dokter, Peter E. Schwartz, Alessandro Santin
Journal: Journal of Clinical Oncology (2015)

e16527 Background: Uterine serous carcinoma (USC) is an aggressive endometrial cancer that carries a poor prognosis. Up to 35% of USC overexpress HER2/neu oncogene at strong (3+) levels while 45% do at moderate (2+) or low (1+) levels. SYD985 (Synthon Biopharmaceuticals BV, Nijmegen, The Netherlands) is a novel HER2-targeting antibody-drug conjugate (ADC) composed of mAb trastuzumab linked to a potent DNA-alkylating agent (duocarmycin). The objective of the study was to explore the anti-tumor activity of SYD985 in USC with different HER2 expression and to compare SYD985 to trastuzumab emtansine (T-DM1) in vitro and in vivo. Methods: Nine primary USC cell lines were evaluated for HER2 expression. Cytotoxicity of SYD985 and T-DM1 was evaluated after exposing cell lines with 1+, 2+, and 3+ HER2 expression for 6-days. Viability assays were performed using propidium iodide-based flow cytometry. Results: SYD985 was 55-115 times more potent when compared to T-DM1 in cell lines with 1+/2+ HER2 expression. In a HER2 1+ the IC50's for SYD985 and T-DM1 were 0.065 µg/mL and 3.58 µg/mL, respectively (p = 0.004) and in HER2 2+ cell lines the IC50's were 0.016 µg/mL and 1.82 µg/mL, respectively (p = 0.005). In HER2 3+ cell lines a statistical trend was noted; IC50's were 0.011 µg/mL and 0.035 µg/mL, respectively (p = 0.06). In a 3+ xenograft model a treatment effect was noted at equal dosages of T-DM1 and SYD985 (single injection of 10 mg/kg) at 7 days (p = .01). With single-injection SYD985 at 3 mg/kg and T-DM1 at 10 mg/kg, a treatment effect was noted at 21 days (p = 0.03). A survival advantage was noted between both SYD985 3 mg/kg and 10 mg/kg compared to T-DM1 10mg/kg at 21 days (p = 0.03 and p = 0.03, respectively). Conclusions: SYD985 is a novel ADC with remarkable activity against USC with strong (3+), moderate (2+), and low (1+) HER2 expression. SYD985 is significantly more potent than T-DM1 in comparative in vitro experiments. Preliminary experiments in USC xenografts not responsive to T-DM1 demonstrate remarkable in vivo activity of SYD985. In vivo experiments in HER2 2+ and 1+ mouse xenograft models are ongoing. Clinical studies with SYD985 in USC patients overexpressing HER2 and disease resistant to chemotherapy are warranted.
Case 14-1962
Authors: J. Gordon Scannell
Journal: New England Journal of Medicine (1962)

Presentation of Case First admission. A fifty-nine-year-old man was referred to the hospital because of a mediastinal mass.Two years previously an x-ray film of the chest taken at another hospital after an upper respiratory infection showed a mediastinal mass; no additional studies were performed at that time. The patient was asymptomatic until three weeks before admission, when a mild upper respiratory infection again developed. An x-ray film of the chest taken shortly before entry demonstrated slight enlargement of the mass.Physical examination revealed bronchial breath sounds and slight dullness to percussion over the left scapula. X-ray films of . . .
Contribution of the depressive perspective to memory function in depression
Authors: R Breslow, J Kocsis, B Belkin
Journal: American Journal of Psychiatry (1981)

The authors used a story recall paradigm to elucidate some aspects of the memory problems of depressive patients. They compared 21 hospitalized depressed patients with a matched group of control subjects for recall of a theme story containing material with positive, negative, and neutral affective tones. The results indicated an overall deficit in the story recall of the depressed patients, most of which could be ascribed to a decrement in recall of the positive themes in the story. Recall of the negative and neutral themes remained intact. These results are consistent with the view that a depressive perspective contributes one component to the memory difficulties of depressed patients.
Urinary-Bladder Management after Total Joint-Replacement Surgery
Authors: J D Michelson, P A Lotke, M E Steinberg
Journal: New England Journal of Medicine (1988)

We conducted a randomized study of 100 patients to examine the efficacy and risks of two methods of urinary-bladder management after total joint-replacement surgery. Patients who had hip or knee replacement were randomly assigned either to Group I, in which indwelling catheters were placed during the operation and removed the next morning, or Group II, in which urinary retention was treated by intermittent catheterization as needed. After the removal of the indwelling catheter, the patients in Group I had a lower incidence of urinary retention than those in Group II (27 vs. 52 percent; P less than 0.01). Bladder distention (volume above 700 ml) was more common in Group II (45 percent as compared with 7 percent in Group I; P less than 0.01) and was associated with an increased need for subsequent long-term catheterization. There was no significant difference between the groups in the rates of urinary tract infection (11 vs. 15 percent). We could not identify patients at high risk for retention or infection on the basis of preoperative urinary symptoms, previous urinary tract surgery, previous urinary tract infection or urinary retention, high-risk medical conditions, sex, type of anesthesia, or age (in the absence of prophylactic treatment). We conclude that the short-term use of an indwelling catheter after extended surgery, such as joint replacement, reduces the incidence of urinary retention and bladder overdistention, without increasing the rate of urinary tract infection.
Association of Religious Involvement and Suicide
Authors: Harold G. Koenig
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Massive Fluid-Suspension Cultures of Certain Mammalian Tissue Cells. III. Exploratory Supplementation Experiments With Chemically Defined Medium NCTC 109
Authors: Jay C. Bryant, Edward L. Schilling, Wilton R. Earle, Virginia J. Evans
Journal: JNCI Journal of the National Cancer Institute (1960)

Chemically defined medium NCTC 109, supplemented only with horse serum in various volume percentages up to 20 percent, proved superior to any other media used for cell-suspension cultures of mouse fibroblast clone 929 (strain L) or two strains derived from that clone. It was not proved possible, however, either to eliminate the horse-serum supplement altogether from medium NCTC 109 or to decrease the percentage of horse serum below 10 percent. This observation is anomalous in view of the fact that strain 2071, derived from clone 929, has been grown successfully in static cultures in this laboratory for several years on completely protein-free medium NCTC 109. It is concluded that the additional mechanical stresses that are imposed upon cells suspended in rapidly agitated fluid-suspension cultures must be compensated for by some physically protective agent, since serum is not essential for the nutrition of strain 2071 in static cultures. Average generation times during the logarithmic phase of certain cultures of these cells, on chemically defined medium supplemented with 20 percent horse serum, are the shortest that have been observed for any agitated fluid-suspension cultures in this laboratory. Glucose was utilized by various cultures of clone 929 at widely different rates, while it was used by various cultures of the derivative strains at similar rates. Methylcellulose had a very limited protective effect on clone 929 cells when they were planted in chemically defined medium in the absence of serum.
PD-033 Right-sided colon cancer is associated with increased frequency of KRAS mutation and with a poor outcome in patients with metastatic disease treated in the first line with bevacizumab and chemotherapy
Authors: L. Ostrizkova, L. Petruželka, K. Hejduk, L. Zdražilová-Dubská, M. Vocka, D. Brancikova, B. Bencsiková, R. Vyzula, R. Obermannová
Journal: Annals of Oncology (2016)
Cancer-specific survival in patients with urothelial carcinoma of the bladder with recurrence after radical cystectomy: External validation of the prognostic risk stratification model.
Authors: Tohru Nakagawa, Haruki Kume, Atsushi Kanatani, Masaomi Ikeda, Akihiko Matsumoto, Satoru Taguchi, Kanae Hiramatsu, Yoshimitsu Komemushi, Taketo Kawai, Yutaka Enomoto, Yasushi Kondo, Motofumi Suzuki, Tetsuya Fujimura, Hiroshi Fukuhara, Toshikazu Okaneya, Yoshikazu Hirano, Kyoichi Tomita, Yoshinori Tanaka, Hiroaki Nishimatsu, Yukio Homma
Journal: Journal of Clinical Oncology (2014)

325 Background: Prognosis of the patients with urothelial carcinoma of the bladder (UCB) who developed recurrence after radical cystectomy (RC) is generally poor, but can be variable. We previously showed that shorter time to recurrence (TTR) after RC, presence of symptoms on recurrence, more than one metastatic sites (organs), high serum C-reactive protein (CRP) level were associated with decreased survival in those patients, and proposed a model to stratify patients into 3 separate risk groups (Nakagawa et al. J Urol. 2013; 189:1275). The aim of this study was to evaluate the prognostic value of this model in a multi-institutional cohort of patients. Methods: We identified 267 patients who experienced disease recurrence after RC for UCB from 9 academic and community hospitals. Patients were categorized into three groups based on the presence of four risk factors, TTR of &lt;1 year, presence of symptoms on recurrence, more than one metastatic sites (organs), and CRP level of ≥0.5 mg/dl: the favourable risk group included patients with none or one of these risk factors; the intermediate risk group with 2 risk factors; and those with 3 or 4 risk factors were assigned to the poor risk group. Results: Overall, median survival time (MST) of the entire cohort was 8.3 months (95%CI, 6.4-9.1). Two hundred and nineteen patients died of their disease with a median survival of 5.9 months. In a multivariate analysis, all of the 4 risk factors were statistically significant for the cancer-specific survival. Sixty-five (27.4%), 84 (35.4%), and 88 (37.1%) patients were in the favorable, intermediate and poor risk group, respectively. Thirty patients were excluded because CRP value was not obtained. MSTs of the patients in the favorable, intermediate and poor risk group were 22.2 (95% CI 16.1-28.3), 7.6 (95% CI 6.3-9.5), and 3.6 (95% CI 2.6-4.4) months, respectively, and the difference was statistically significant (p&lt;0.001, log-rank test). Conclusions: We confirmed the prognostic value of our previous criteria based on the four variables in patients with recurrence after RC for UCB. This criteria would help in patient counseling and clinical trial design.
Latrophilin receptors: novel bronchodilator targets in asthma
Authors: A Faiz, C Donovan, M AE Nieuwenhuis, M van den Berge, D S Postma, S Yao, C Y Park, R Hirsch, J J Fredberg, G Tjin, A J Halayko, K L Rempel, J P T Ward, T Lee, Y Bossé, D C Nickle, M Obeidat, Judith M Vonk, J L Black, B G Oliver, R Krishnan, B McParland, J E Bourke, J K Burgess
Journal: Thorax (2016)

Asthma affects 300 million people worldwide. In asthma, the major cause of morbidity and mortality is acute airway narrowing, due to airway smooth muscle (ASM) hypercontraction, associated with airway remodelling. However, little is known about the transcriptional differences between healthy and asthmatic ASM cells.To investigate the transcriptional differences between asthmatic and healthy airway smooth muscle cells (ASMC) in culture and investigate the identified targets using in vitro and ex vivo techniques.Human asthmatic and healthy ASMC grown in culture were run on Affymetrix_Hugene_1.0_ST microarrays. Identified candidates were confirmed by PCR, and immunohistochemistry. Functional analysis was conducted using in vitro ASMC proliferation, attachment and contraction assays and ex vivo contraction of mouse airways.We suggest a novel role for latrophilin (LPHN) receptors, finding increased expression on ASMC from asthmatics, compared with non-asthmatics in vivo and in vitro, suggesting a role in mediating airway function. A single nucleotide polymorphism in LPHN1 was associated with asthma and with increased LPHN1 expression in lung tissue. When activated, LPHNs regulated ASMC adhesion and proliferation in vitro, and promoted contraction of mouse airways and ASMC.Given the need for novel inhibitors of airway remodelling and bronchodilators in asthma, the LPHN family may represent promising novel targets for future dual therapeutic intervention.
O-014 Evaluation of depth of response within a volumetric model in patients with metastatic colorectal cancer: results of the SIRFLOX study
Authors: V. Heinemann, G. van Hazel, N. Sharma, M. Findlay, J. Ricke, M. Peeters, V. Gebski, M. Van Buskirk, P. Gibbs
Journal: Annals of Oncology (2016)
Should be managed in urological units
Authors: J D Karanjavala, J F Buckley
Journal: BMJ (1996)

EDITOR,—We take issue with several points in Linda Cardozo's editorial on postmenopausal cystitis.1 The comment that “for those women in whom oestrogen therapy is ineffective or inappropriate, it is important to exclude underlying pathology” is misleading as it implies that oestrogen should …
Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report
Authors: David M. Maahs, Bruce A. Buckingham, Jessica R. Castle, Ali Cinar, Edward R. Damiano, Eyal Dassau, J. Hans DeVries, Francis J. Doyle, Steven C. Griffen, Ahmad Haidar, Lutz Heinemann, Roman Hovorka, Timothy W. Jones, Craig Kollman, Boris Kovatchev, Brian L. Levy, Revital Nimri, David N. O’Neal, Moshe Philip, Eric Renard, Steven J. Russell, Stuart A. Weinzimer, Howard Zisser, John W. Lum
Journal: Diabetes Care (2016)

Research on and commercial development of the artificial pancreas (AP) continue to progress rapidly, and the AP promises to become a part of clinical care. In this report, members of the JDRF Artificial Pancreas Project Consortium in collaboration with the wider AP community 1) advocate for the use of continuous glucose monitoring glucose metrics as outcome measures in AP trials, in addition to HbA1c, and 2) identify a short set of basic, easily interpreted outcome measures to be reported in AP studies whenever feasible. Consensus on a broader range of measures remains challenging; therefore, reporting of additional metrics is encouraged as appropriate for individual AP studies or study groups. Greater consistency in reporting of basic outcome measures may facilitate the interpretation of study results by investigators, regulatory bodies, health care providers, payers, and patients themselves, thereby accelerating the widespread adoption of AP technology to improve the lives of people with type 1 diabetes.
The Effect of Insulin Antibodies on the Metabolic Action of Inhaled and Subcutaneous Insulin
Authors: Tim Heise, Susanne Bott, Corinna Tusek, Jens-Armin Stephan, Tom Kawabata, Deborah Finco-Kent, Cameron Liu, Alan Krasner
Journal: Diabetes Care (2006)

We thank Prof. Chantelau (1) for his inquiry about serum free insulin levels in our study (2). Free insulin levels were measured in the fasting state (i.e., before trial drug administration) at baseline and at weeks 12 and 24. These free insulin levels (resulting from both the constant intravenous insulin infusion that was maintained throughout the in-patient study days as well as any residual concentration remaining from the previous dose of subcutaneous …
ZFN Mediated Targeting Of Albumin “Safe Harbor” Results In Therapeutic Levels Of Human Factor VIII In a Mouse Model Of Hemophilia A
Authors: Xavier M Anguela, Rajiv Sharma, Yannick Doyon, Thomas Wechsler, David E Paschon, Robert J Davidson, Shangzhen Zhou, Philip D Gregory, Michael C. Holmes, Edward J Rebar, Katherine A. High
Journal: Blood (2013)
Case 7-1987
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, D.J. Glotzer, C.C. Compton
Journal: New England Journal of Medicine (1987)

Presentation of CaseA 46-year-old woman was admitted to the hospital because of abdominal pain.She was well until the morning of admission, when she experienced the abrupt onset of diffuse abdominal pain, without nausea or vomiting. She passed a normal stool that morning. She was brought to the hospital.The patient was a native of Canada and was married, with one child. There was a history of an abdominal hysterectomy with bilateral salpingo-oophorectomy and incidental appendectomy, performed 15 years earlier because of an ovarian cyst. She had consumed sushi in recent days, had used conjugated estrogens since the hysterectomy, . . .
This Is My Hospital's Performance on Quality of Care—No Excuses
Authors: Jay G. Berry
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Leukemic Stem Cell Quantification Is Of Prognostic Value In Newly Diagnosed Patients In Chronic Phase Chronic Myeloid Leukemia (CML-CP) Receiving Nilotinib Therapy: Results From The ENEST1st Stem Cell Substudy
Authors: Noortje Thielen, Johan Richter, Gisela Barbany, Thoas Fioretos, Frank Giles, Bjorn T Gjertsen, Andreas Hochhaus, Gert J. Ossenkoppele, Kimmo Porkka, Gerrit Jan Schuurhuis, Sieghart Sopper, Leif Stenke, Sara Thunberg, Dominik Wolf, Jeroen Janssen, Satu Mustjoki
Journal: Blood (2013)
Analyse histologique in vivo en temps réel des polypes colorectaux grâce à une pince à biopsie “optique” basée sur la spectroscopie de fluorescence induite par laser
Authors: G. Rahmi
Journal: Endoscopy (2016)

Les très petits polypes (< 5 mm) ont une prévalence de plus de 50 % au cours des coloscopies de dépistage du cancer colorectal. Lorsqu'ils sont situés dans le rectosigmoïde ces polypes ont un risque de dégénérescence entre 0 et 0,008 %. Une méthode d'analyse histologique en temps réel pourrait permettre de repérer les polypes rectosigmoïdiens bénins et ne pas les réséquer, ou de les réséquer avant de les jeter (Resect and Discard). Cette méthode, selon les recommandations américaines (ASGE), est acceptable si la valeur prédictive positive est supérieure à 90 % et si la prédiction de l'intervalle de surveillance endoscopique est correcte dans plus de 90 % des cas.