tbuckley/cabot-search huggingface dataset:
Autologous Marrow in Treatment of Nitrogen Mustard-Induced Marrow Depression
Authors: G A KAISER, F P HERTER, A M MARKOWITZ, S EVANS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-147 The impact of body mass index on outcomes following oesophagectomy in western patients: a meta-analysis
Authors: F Puccetti, A Chaudry, A Venerus, W Allum
Journal: Gut (2015)

<h3>Introduction</h3> Multiple groups have previously reported the influence of BMI on outcomes following oesopheageal surgery but their conclusions have been limited by a lack of clear delineation of patient characteristics as well as geographical location and the nature of multimodal treatment. In order to address the specific question concerning the impact of preoperative BMI on western patients’ outcomes after oesophageal cancer surgery we have performed a meta-analysis, taking into account histology characteristics wherever possible. <h3>Method</h3> Between December 2014 and January 2015 a comprehensive electronic search was performed to identify Western publications relating to BMI and outcomes after oesophagectomy. Articles that did not report preoperative BMI, morbidity, early mortality and 5 years overall survival were excluded. The search was performed using Pubmed and the reference lists for each of the articles included was also reviewed in order to find any additional studies. Statistical analyses were performed using OpenMetaAnalyst software (Version 10.10). <h3>Results</h3> 161 records were examined, 9 western studies were included with a total of 3150 pts of which 317 were specifically affected by adenocarcinoma. The study population was stratified into 2 groups: normal group (BMI &lt;25) and higher BMI group (BMI &gt;30). Whilst higher BMI was associated with a greater risk for anastomotic leaks (near 25% with a p-value of 0.102), bleeding (18% and 0.213), wound infections (25% and 0.090) and poorer long term survival (near 20% and 0.090) this was not found to be statistically significant. Cardiac, pulmonary and any major complications were not significantly different between the 2 groups. On the other hand, there was a 20% greater risk for early postoperative mortality in the normal BMI group although the difference did not reach statistical significance as well as recurrent laryngeal nerve injury. Normal BMI was also significantly associated with chyle leaks (0.021). Stratification according to histology was possible in the analysis of 3 postoperative complications (anastomotic leakages, pulmonary events and early mortality). In the adenocarcinoma group High BMI was significantly associated with pulmonary complications (0.009). <h3>Conclusion</h3> This meta-analysis shows that in Western studies BMI above 30 is not associated with increased mortality or morbidity after oesophageal surgery, although there is an increase in pulmonary complications of those who have adenocarcinoma. BMI &lt;25 is strongly associated with Chyle leaks. These results suggest that BMI should not exclude patients from being treated with curative intent in multimodal treatment; however the increased risk of pulmonary complications should trigger careful preoperative respiratory assessment and optimisation. <h3>Disclosure of interest</h3> None Declared.
THU0352 Risk of Status Epilepticus and Intractable Epilepsy in Systemic Lupus Erythematosus Patients with Lupus Nephritis
Authors: T. Mehta, K. Sheth, S. Puri, R. Soni, V. Sheth, A.L. Parke
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Seizures are well described primary manifestation of Systemic Lupus Erythematosus (SLE). Lupus nephritis can further decrease seizure threshold due to hypertension, uremia and electrolyte abnormalities. In this study we investigated the risk of intractable epilepsy and status eplilepticus (general and partial) in SLE patients who have lupus nephritis. <h3>Objectives</h3> To determine if lupus nephritis is an independent predictors of status epilepticus, grand mal status or epilepsia partialis continua in patients with SLE. <h3>Methods</h3> We queried the Healthcare Cost and Utilization Project9s (HCUP) Nationwide Inpatient Sample (NIS) between 2002 and 2011 and separated the hospitalizations due to or with SLE using ICD 9 diagnostic codes previously established by HCUP. Among this population, we examined the patients with lupus nephritis, and compared their risk of seizures using the logistic regression model. The model was controlled for variables which included age, sex, race, hypertension, ischemic stroke, intracranial bleed, chronic kidney disease, uremia, antiphospholipid antibodies, craniotomy, head trauma, hyponatremia, psychosis, lupus encephalitis, ischemic stroke, intracranial infections, brain neoplasms, use of immunosuppression, alcohol use, abnormal electroencephalogram (EEG) and use of antiepileptics. Using SAS 9.2, survey procedures were used to identify multivariate predictors of intractable epilepsy, grand mal status and epilepsia partialis continua. <h3>Results</h3> A total of 1,631,680 who were hospitalized with SLE were available for analysis of which 907 (0.06%) patients had intractable epilepsy, 2092 (0.13%) patients had grand mal status and 146 (0.01%) patients had epilpesia partialis continua. The odds ratio (OR) of intractable epilepsy among SLE patients with lupus nephritis was 0.756 (Confidence Interval (CI) =0.411-1.387, p value=0.3659), OR for grand mal status was 1.022 (CI=0.735-1.423, p value=0.8955); whereas OR for epilepsia partialis continua was 3.000 (CI=1.208-7.453, p value=0.0179). <h3>Conclusions</h3> Lupus nephritis is an independent predictor of epilepsia partialis continua in SLE patients; whereas it is not an independent predictor of intractable epilepsy or grand mal status. <h3>Disclosure of Interest</h3> None declared
PWE-143 Provision of care for patients with autoimmune hepatitis (aih) in 27 hospitals across the united kingdom
Authors: VM Gordon
Journal: Gut (2015)

<h3>Introduction</h3> The National Liver Disease Strategy for England aims to provide high-quality care for all patients with all liver disease. There have been moves towards subspecialist management of patients with chronic viral hepatitis. It is unclear if this is also the case for Autoimmune Hepatitis (AIH). We are conducting a (BSG and HQIP funded) Management and Outcome Audit of AIH in 28 UK centres of varying size. <h3>Method</h3> To report on current infrastructure in hospitals participating in the Multi-centre Audit. Hospitals used a web-based data collection tool to answer questions about their staff, facilities and service provision. <h3>Results</h3> We received <b>i</b>nformation from 27 hospitals: 13 classified themselves as District General Hospitals (DGHs) (9 with &gt;500 beds) and 14 as University Hospitals (all with &gt;500 beds). Fifteen hospitals accepted Hepatology referrals from other hospitals. Total number of Consultant Gastroenterologists per hospital was (median (range)) 9(3–21). Of these, 2 (0–10) were Hepatologists (&gt;70% of workload liver disease) and a further 0 (0–4) had an interest in liver disease (40–70% of workload). Eight hospitals (35%), all of them DGHs, did not have a Hepatologist and 3 (12%) had no Consultant with an interest in liver disease. Number of Consultant Gastroenterologists managing AIH per hospital was 3.5(1–10) and number of Hepatologists managing AIH was 2(0–10). The percentage of all the Consultants who managed AIH was 43(20–100)%. This was higher in DGHs than in University Hospitals: 100(20–100%) vs 37(20–100%). In 8 hospitals (7 DGHs), all of the 6(3–10) Gastroenterologists managed AIH. In University Hospitals, all Hepatologists managed AIH and in 5 hospitals (with Hepatologists), so did other Gastroenterologists. Eighteen hospitals (67%) had 1(0–6) specialist nurses mainly managing liver disease and 18 (67% provided telephone advice for patients with liver disease. However, in only three hospitals (12%) did these nurses manage outpatients with AIH. 16 hospitals (59%) had at &gt;1 Histopathologist with an interest in liver disease and 70% had a joint clinical-pathological meeting. Eleven hospitals (42%) provided hospital information sheets for patients with AIH. Only three (12%) had departmental hospital guidelines for the management of AIH. Nine (33%) had database of patients with AIH. <h3>Conclusion</h3> In contrast to chronic viral hepatitis, there has been little development of subspecialisation amongst Gastroenterology and Hepatology physicians and nurses in regard to management of AIH. There is variability in service provision but it is unclear if this influences outcome. All centres in the Audit now have a database to monitor their patients with AIH: this should help improve resource provision and aid management. <h3>Disclosure of interest</h3> None Declared.
New directions in diagnosis: the longitudinal processes of schizophrenia
Authors: J S Strauss, J J Bartko, W T Carpenter
Journal: American Journal of Psychiatry (1981)

Kraepelin's description of "dementia praecox" was a synthesizing influence in a field that had for too long been fragmented in its thinking about severe psychiatric disorders. Now, once again, the field is attempting to deal with some of the complexities involved in psychopathology and its evolution, complexities that have been reemphasized by newer descriptive research methods. To account for patients deviations from stereotyped diagnostic and prognostic concepts, multiple aspects of course of disorder have been defined and principles of multiaxial diagnosis supported. These principles can provide a basic structure for practice and research using a biopsychosocial orientation within the context of a system model.
The Inhibition of Gastric Secretion in Dogs by Human Gastric Juice and Gastric Mucin&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/xref&gt;
Authors: Charles M. Blackburn, M. D., Charles F. Code, M. D.
Journal: JNCI Journal of the National Cancer Institute (1949)

The Inhibition of Gastric Secretion in Dogs by Human Gastric Juice and Gastric Mucin Get access Charles M. Blackburn, M. D., Charles M. Blackburn, M. D. Division of Medicine Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles F. Code, M. D. Charles F. Code, M. D. Section on Physiology, Mayo Clinic and Mayo Foundation, Rochester, Minn. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 2, October 1949, Pages 337–338, https://doi.org/10.1093/jnci/10.2.337 Published: 01 October 1949
Huge Data-Sharing Project Launched
Authors: Suzanne Rose
Journal: Cancer Discovery (2015)

Aiming to advance precision medicine in oncology and improve patient care, the American Association for Cancer Research has launched an international initiative known as AACR Project Genomics, Evidence, Neoplasia, Information, Exchange (GENIE). The venture will pool existing and future next-generation clinical sequencing data with longitudinal clinical outcomes and related pathology reports from several institutions in the United States, Canada, and Europe, to find new mutations, assess potential biomarkers, and identify patient populations that might benefit from existing treatments.
SARS: Retrospective cohort study among German guests of the Hotel 'M', Hong Kong
Authors: D Radun, M Niedrig, A Ammon, K Stark
Journal: Eurosurveillance (2003)

Hong Kong played a pivotal role in the international spread of the Severe Acute Respiratory Syndrome (SARS): a doctor who spent the night of 21-22 February 2003 at Hotel 'M' was identified as the index case for four national and international clusters of SARS. In parallel to the international collaborative study led by WHO and United States, a retrospective study on the cohort of German persons staying at Hotel 'M' was conducted. The inclusion criteria covered a period from 21 February to 3 March 2003 to allow the detection of cases possibly due to environmental contamination. In the twenty-one German guests traced as having stayed at Hotel "M" during this period, one case of laboratory confirmed SARS was found. The case history suggests that close vicinity to the index patient may have played a role in transmission. In line with findings of environmental investigations in the hotel, environmental contamination should be considered as a possible source of infection.
Blood safety and nucleic acid testing in Europe
Authors: S Laperche
Journal: Eurosurveillance (2005)

Over the past two decades, a long series of specific and non-specific measures have been introduced into the screening of blood donations in order to reduce the residual risk of transmission of bloodborne viruses. The latest specific measure has been viral nucleic acid testing (NAT), introduced by the European plasma industry in 1995, and subsequently introduced for blood donations in several countries in Europe and elsewhere. NAT was implemented to reinforce the safety of the blood supply; it can detect acute viral infections during the ‘window period’, that were not being detected by the serological screening methods used at that time. To assess the impact of NAT on the safety of the blood supply, it is essential to estimate the residual risk of viral transmission. In this issue, six European countries (France, Germany, Italy, Spain, Switzerland and the United Kingdom) that have recently implemented NAT describe their experiences and the results of the evaluation of the residual risk of viral transmission in their blood supply [1-6].
BACTERIA OF THE TRIBE MIMEAE
Authors: H C LEOPOLD, B GODWIN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use and impact of selective internal radiation therapy (SIRT) in routine care patients with metastatic colorectal cancer (mCRC).
Authors: Belinda Lee, Hui-Li Wong, Kathryn Maree Field, Louise M. Nott, Jeremy David Shapiro, Rachel Wong, Jeremy David Power, Suzanne Kosmider, Lionel Lim, Peter Gibbs
Journal: Journal of Clinical Oncology (2016)

742 Background: The liver is the dominant site of metastasis in patients (pts) with mCRC. Radioembolisation is a potential option in the multidisciplinary management of these patients. Recently initial analysis of a randomised controlled trial (RCT) in the 1 st line setting demonstrated no overall progression free survival (PFS) benefit from adding SIRT, but prolongation of liver PFS (HR 0.69, p=0.002) was seen. Methods: Consecutive pts with mCRC enrolled from January 2009 were identified from a prospective multi-site Australian registry. Characteristics and outcomes for pts selected for treatment with SIRT were analysed. Results: Of 1,694 pts with mCRC, 580 (34.2%) had liver only disease at diagnosis, 409/580 (70.5%) with synchronous vs 166/580 (28.6%) with metachronous disease. Of pts with liver only disease, 187 (32.2%) were considered resectable at diagnosis, 100 (17%) as potentially resectable and 293 (51%) were treated with palliative intent. Overall 47 pts received SIRT with 1 st line chemotherapy (CT). SIRT treated pts were more likely to have a synchronous presentation (85% vs 68%, p=0.01), liver only disease (83.0% vs 27.3%, p=&lt;0.01), to be ECOG 0 (51.1% vs 34.6%, p=0.01), to be younger (60.8 years vs. 65.9 years, p=0.008) and to be enrolled on a RCT (38.3% vs 7.3%, p=&lt;0.01). In the liver only population treated with palliative intent, SIRT treated pts (n=30) vs CT only pts (n=188) had a median PFS of 10.6 months vs 9.9 months (HR 0.87, p = 0.18) and a median OS of 24.3 months vs 19.3 months (HR 0.73, p = 0.04). Conclusions: SIRT is rarely used in the 1 st line treatment of mCRC in routine practice. The available data suggests that OS gains can be seen in the absence of differences in PFS. However, this observed differential effect on survival maybe due to selection biases. SIRT treated patients were significantly younger and fitter than the CT alone group. Future analyses will include a multivariate analysis and examine the impact of the recently presented SIRFLOX trial data on the use of SIRT in clinical practice.
Hereditary and Pathogenic Nature of Mutant Mitochondria in &lt;italic&gt;Nepeta&lt;/italic&gt;&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: M. W. Woods, H. G. duBuy
Journal: JNCI Journal of the National Cancer Institute (1951)

Hereditary and Pathogenic Nature of Mutant Mitochondria in Nepeta Get access M. W. Woods, M. W. Woods cytologist National Cancer Institute Search for other works by this author on: Oxford Academic PubMed Google Scholar H. G. duBuy H. G. duBuy biophysicist National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 6, June 1951, Pages 1105–1151, https://doi.org/10.1093/jnci/11.6.1105 Published: 01 June 1951 Article history Received: 16 January 1951 Published: 01 June 1951
Analysis of Outcomes By Patient Subgroups in Patients with Myelofibrosis Treated with Pacritinib Vs Best Available Therapy (BAT) in the Phase III Persist-1 Trial
Authors: Alessandro M. Vannucchi, Ruben A. Mesa, Francisco Cervantes, Ritam Prasad, Janos Jakucs, Anna Elinder, Christian Recher, Peter A. te Boekhorst, Steven Knapper, Tim Somervaille, James P. Dean, Tanya Granston, Adam Mead, Claire N. Harrison
Journal: Blood (2015)
Effect of chemical conjugation of recombinant single-chain urokinase- type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo
Authors: M Dewerchin, HR Lijnen, JM Stassen, F De Cock, T Quertermous, MH Ginsberg, EF Plow, D Collen
Journal: Blood (1991)
Chronic Kidney Disease
Authors: Aria A. Razmaria
Journal: JAMA (2016)

Katherine T. Mills, PhD; Jing Chen, MD; Wei Yang, PhD; Lawrence J. Appel, MD; John W. Kusek, PhD; Arnold Alper, MD; Patrice Delafontaine, MD; Martin G. Keane, MD; Emile Mohler, MD; Akinlolu Ojo, MD, PhD; Mahboob Rahman, MD; Ana C. Ricardo, MD; Elsayed Z. Soliman, MD; Susan Steigerwalt, MD; Raymond Townsend, MD; Jiang He, MD, PhD; for the Chronic Renal Insufficiency Cohort (CRIC) Study Investigators
Dietary Sodium and Cardiovascular Disease Risk — Measurement Matters
Authors: Mary E. Cogswell, Kristy Mugavero, Barbara A. Bowman, Thomas R. Frieden
Journal: New England Journal of Medicine (2016)

The benefit of reducing dietary sodium for lowering the risk of cardiovascular disease has been questioned because some studies have also linked low sodium intake with increased CVD risk. Application of Hill's criteria, however, indicates that the association is not causal.
Expanded Natural Killer Cells For The Control Of Minimal Residual Disease In Ph+ Acute Lymphoblastic Leukemia Patients
Authors: Giovanni Fernando Torelli, Nadia Peragine, Sara Raponi, Paola Mariglia, Simona Pauselli, Maria Stefania De Propris, Antonella Vitale, Anna Guarini, Robin Foá
Journal: Blood (2013)