AB0879 Differences Between Men and Women with Severe Knee Osteoarthritis
Authors: S.D. Jandric
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Knee osteoarthritis is one of the leading causes of global disability. Clinical manifestation of the degenerative changes in knee joint and periarticular structures in both, men and women, can lead to functional deficit, pain and stiffness in patients with severe knee osteoarthritis. It may influence the quality of life. <h3>Objectives</h3> The aim of this study was to investigate the occurrence of differences between men and women with severe knee osteoarthritis. <h3>Methods</h3> Clinical prospective randomized study of 192 (144 female and 48 male) patients with average age 67.53±9.24 years (range of 45 to 78 years) with diagnosis of severe osteoarthritis of the knee according to American College of Rheumatology. BMI, age, musculoskeletal disease, other comorbities, circumferences of the waist, social states and quality of life were measured. Quality of life was measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) that measured health-related quality of life. All patients completed this questionnaire. <h3>Results</h3> There is statistically significant difference between male and female patients with severe knee osteoarthritis in our study (p&lt;0.001). Average age of the male was 70.75±4.6 yrs and average age of female patients was 66.46±10.13 yrs in our study. This difference was statistically significant (t= -2.15, p&lt;0.05). Average value of the BMI was 31.48±5.37 kg/m<sup>2</sup>. It was in the range of obesities in both groups of patients: male (29.23±3.5 kg/m<sup>2</sup>) and female (32.22±0.5.68 kg/m<sup>2</sup>). This difference was statistically significant, (t=-2.496, p&lt;0.01). Average value of the circumferences of the waist was 103.62±10.48 cm (109.54±10.09 cm in the male and 101.65±9.92cm in female group of the patients). There was statistically significant difference between these two groups (t=3.45, p&lt;0.001). Average value of other musculoskeletal diseases in all patients was 0.37±0.6 and with other diseases (comorbidities) 0.33±0.59. Comorbidities were statistically significantly higher in female patients (t=3.3469, p&lt;0.001), but musculoskeletal diseases were not (t=-0.106, p&gt;0.05) as well as social states (t=-0.803, p&gt;0.05) and stiffness (t=1.72996, p&gt;0.05). Domain of the pain was statistically significantly higher in female patients (t=-4.659, p&lt;0.001) and physical function was lower than in male patients (t=–7.914, p&lt;0.001). Quality of life measured by WOMAC was statistically significantly lower in female than in male patients with knee osteoarthritis (t=-8.277, p&lt;0.001). Logistic regression showed that significant predictor of sex differences in patients with severe knee osteoarthritis was WOMAC total score. <h3>Conclusions</h3> These results suggest that men with severe knee osteoarthritis have better quality of life than women with severe knee osteoarthritis. Quality of life is significant predictor of sex differences between men and women with severe knee osteoarthritis. These findings can help us in planning treatment for patients with knee osteoarthritis. <h3>References</h3> Cross M, Smith E, Hoy D, et al. The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis 2014;73(7):1323-30. Bellamy N. Outcome measurement in osteoarthritis clinical trials. J Rheumatol 1995;22(suppl 43):49–51. <h3>Disclosure of Interest</h3> None declared