tbuckley/cabot-search huggingface dataset:
The Influence of Succinate and 2,4-Dinitrophenol on the Respiratory Activity of Mouse Cancers and Normal Tissues
Authors: Mark Woods
Journal: JNCI Journal of the National Cancer Institute (1956)

The Influence of Succinate and 2,4-Dinitrophenol on the Respiratory Activity of Mouse Cancers and Normal Tissues Mark Woods Mark Woods Cytochemistry Section, Laboratory of Biochemistry, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages 615–629, https://doi.org/10.1093/jnci/17.5.615 Published: 01 November 1956 Article history Received: 27 June 1956 Published: 01 November 1956
Bifrontal Approach to Aneurysms of the Anterior Communicating Artery
Authors: T J SPEAKMAN, J L BARLASS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Peripheral Blood Lymphocyte/Monocyte Ratio At 6 Months After Remission As a Predictor Of Relapse After R-CHOP Therapy In Patients With Diffuse Large B-Cell Lymphoma
Authors: Reina Watanabe, Naoto Tomita, Yasufumi Ishiyama, Kumiko Kishimoto, Eri Yamamoto, Yoshimi Ishii, Hiroyuki Takahashi, Kazuho Miyashita, Yukako Hattori, Satomi Ito, Takuya Miyazaki, Hirotaka Takasaki, Rika Kawasaki, Hideyuki Kuwabara, Masatsugu Tanaka, Hideyuki Koharazawa, Jun Taguchi, Katsumichi Fujimaki, Rika Sakai, Yoshiaki Ishigatsubo
Journal: Blood (2013)
Judge orders amputation against patient’s wishes
Authors: Clare Dyer
Journal: BMJ (2016)

A woman with an infected leg should have part of the limb amputated against her wishes, a High Court judge has ruled.

Mr Justice Bodey made the ruling in the Court of Protection after deciding that the unnamed woman, who is in her 50s, lacked the mental capacity to take her own decisions.

He ruled that she should be given the “opportunity to live,” after hearing evidence from medical specialists and visiting her in the hospital where she is an inpatient. He also heard from her two adult children, who wanted her to have the surgery. …
Low Diagnostic Yield of Elective Coronary Angiography
Authors: Antonio Abbate, George Vetrovec, Filippo Crea
Journal: New England Journal of Medicine (2010)

Background-Guidelines for triaging patients for cardiac catheterization recommend a risk assessment and noninvasive testing.We determined patterns of noninvasive testing and the diagnostic yield of catheterization among patients with suspected coronary artery disease in a contemporary national sample.Methods-From January 2004 through April 2008, at 663 hospitals in the American College of Cardiology National Cardiovascular Data Registry, we identified patients without known coronary artery disease who were undergoing elective catheterization.The patients' demographic characteristics, risk factors, and symptoms and the results of noninvasive testing were correlated with the presence of obstructive coronary artery disease, which was defined as stenosis of 50% or more of the diameter of the left main coronary artery or stenosis of 70% or more of the diameter of a major epicardial vessel.Results-A total of 398,978 patients were included in the study.The median age was 61 years; 52.7% of the patients were men, 26.0% had diabetes, and 69.6% had hypertension.Noninvasive testing was performed in 83.9% of the patients.At catheterization, 149,739 patients (37.6%) had obstructive coronary artery disease.No coronary artery disease (defined as <20% stenosis in all vessels) was reported in 39.2% of the patients.Independent predictors of obstructive coronary artery disease included male sex (odds ratio, 2.70; 95% confidence interval [CI], 2.64 to 2.76), older age (odds ratio per 5-year increment, 1.29; 95% CI, 1.28 to 1.30), presence of insulindependent diabetes (odds ratio, 2.14; 95% CI, 2.07 to 2.21), and presence of dyslipidemia (odds ratio, 1.62; 95% CI, 1.57 to 1.67).Patients with a positive result on a noninvasive test were moderately more likely to have obstructive coronary artery disease than those who did not undergo any testing (41.0% vs. 35.0%;P<0.001; adjusted odds ratio, 1.28; 95% CI, 1.19 to 1.37).Conclusions-In this study, slightly more than one third of patients without known disease who underwent elective cardiac catheterization had obstructive coronary artery disease.Better strategies for risk stratification are needed to inform decisions and to increase the diagnostic yield of cardiac catheterization in routine clinical practice.For patients in stable condition who are undergoing assessment for obstructive coronary artery disease, guidelines recommend continued observation in the case of patients who are at very low risk, noninvasive stress testing to determine the need for cardiac catheterization in the case of patients at intermediate risk, and direct referral for catheterization in the case
Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR
Authors: Maximilian Haeussler, Kai Schönig, Hélène Eckert, Alexis Eschstruth, Joffrey Mianné, Jean-Baptiste Renaud, Sylvie Schneider-Maunoury, Alena Shkumatava, Lydia Teboul, Jim Kent, Jean-Stephane Joly, Jean-Paul Concordet
Journal: Genome biology (2016)

The success of the CRISPR/Cas9 genome editing technique depends on the choice of the guide RNA sequence, which is facilitated by various websites. Despite the importance and popularity of these algorithms, it is unclear to which extent their predictions are in agreement with actual measurements.
Multimodal Eph/Ephrin signaling controls several phases of urogenital development
Authors: Christiane Peuckert, Bejan Aresh, Pavlo Holenya, Derek Adams, Smitha Sreedharan, Annika Porthin, Louise Andersson, Hanna Pettersson, Stefan Wölfl, Rüdiger Klein, Leif Oxburgh, Klas Kullander
Journal: Kidney International (2016)
Postoperative Radiation Therapy Is Associated with Longer Overall Survival in Completely Resected Stage II and III Thymoma—An Analysis of the International Thymic Malignancies Interest Group Retrospective Database
Authors: Andreas Rimner, Xiaopan Yao, James Huang, Alberto Antonicelli, Usman Ahmad, Robert J. Korst, Frank Detterbeck, Daniel R. Gomez
Journal: Journal of Thoracic Oncology (2016)
T Cell Products of Defined CD4:CD8 Composition and Prescribed Levels of CD19CAR/Egfrt Transgene Expression Mediate Regression of Acute Lymphoblastic Leukemia in the Setting of Post-Allohsct Relapse
Authors: Rebecca A Gardner, Julie R Park, Karen S Kelly-Spratt, Olivia Finney, Hannah Smithers, Virginia Hoglund, Christopher Brown, Stephanie Mgebroff, Catherine G. Lindgren, Assaf P Oron, Marie Bleakley, Michael C Jensen
Journal: Blood (2014)
The Cost of Residency Training in Teaching Health Centers
Authors: Marsha Regenstein, Kiki Nocella, Mariellen Malloy Jewers, Fitzhugh Mullan
Journal: New England Journal of Medicine (2016)

When the full net cost of residency training in an ambulatory setting is considered, including direct and indirect costs and revenue attributable to residents' services, it becomes clear that the current payment rate for Teaching Health Centers is far from adequate.
Influence de la formation clinique sur l’interprétation des images d’endomicroscopie confocale
Journal: Endoscopy (2016)

L’endomicroscopie confocale (EMC) est souvent considérée comme de l’histologie in vivo. On pourrait donc supposer qu’une formation anatomopathologique est nécessaire pour l’interprétation des images. Cependant, les images obtenues en EMC diffèrent des images histologiques par leur orientation dans un plan horizontal, la vitesse de leur défilement, l’absence de visualisation du noyau cellulaire et l’apport de données fonctionnelles vasculaires car il s’agit de l’examen d’un tissu vivant.
Long-term follow-up of 85 patients with obsessive-compulsive disorder
Authors: L M Orloff, M A Battle, L Baer, L Ivanjack, A R Pettit, M L Buttolph, M A Jenike
Journal: American Journal of Psychiatry (1994)

In this study, long-term outcome for patients with obsessive-compulsive disorder treated with serotonin reuptake inhibitor medications was examined. The records of 85 patients who had first been evaluated at least 1 year previously (the mean follow-up period was 773 days) were reviewed. Information was collected on age at onset of symptoms, time since first evaluation, and scores on several scales measuring symptom severity, including the Yale-Brown Obsessive Compulsive Scale. Comparison of these baseline data with Yale-Brown scale scores at the most recent follow-up visit showed that 74 (87%) of the patients had responded to treatment. No predictors of improvement were found.
Case 53-1962
Authors: Alfred Kranes, Benjamin Castleman
Journal: New England Journal of Medicine (1962)

Presentation of CaseA seventy-two-year-old man entered the hospital because of fever.The patient had been relatively well and physically active until one month before admission, when fatigue and anorexia began, with a subsequent loss of 15 pounds in weight. Two weeks later pain in the legs and lower portion of the back developed after strenuous physical activity. X-ray films of the spine a week before entry demonstrated degenerative changes in the lumbar intervertebral joints and forward displacement of the body of the fourth lumbar vertebra. With bed rest the pain decreased, but the temperature began to rise daily as . . .
P-092 Clinico- epidemiological and therapeutic profile of gastric adenocarcinoma
Authors: F.Z. Boudinar, K. Rekai, G. Bettache, S. Belalia, F. Betkaoui, F. Louala, A. Zemmour, N. Sadji, B. Larbaoui, A. Boukerche
Journal: Annals of Oncology (2015)
Single-cell genome-wide bisulfite sequencing uncovers extensive heterogeneity in the mouse liver methylome
Authors: Silvia Gravina, Xiao Dong, Bo Yu, Jan Vijg
Journal: Genome biology (2016)

Transmission fidelity of CpG DNA methylation patterns is not foolproof, with error rates from less than 1 to well over 10 % per CpG site, dependent on preservation of the methylated or unmethylated state and the type of sequence. This suggests a fairly high chance of errors. However, the consequences of such errors in terms of cell-to-cell variation have never been demonstrated by experimentally measuring intra-tissue heterogeneity in an adult organism. We employ single-cell DNA methylomics to analyze heterogeneity of genome-wide 5-methylcytosine (5mC) patterns within mouse liver. Our results indicate a surprisingly high level of heterogeneity, corresponding to an average epivariation frequency of approximately 3.3 %, with regions containing H3K4me1 being the most variable and promoters and CpG islands the most stable. Our data also indicate that the level of 5mC heterogeneity is dependent on genomic features. We find that non-functional sites such as repeat elements and introns are mostly unstable and potentially functional sites such as gene promoters are mostly stable. By employing a protocol for whole-genome bisulfite sequencing of single cells, we show that the liver epigenome is highly unstable with an epivariation frequency in DNA methylation patterns of at least two orders of magnitude higher than somatic mutation frequencies.
Late Care of the Demented Patient
Authors: James A. Haycox
Journal: New England Journal of Medicine (1980)

Most of the time when I have been ill, I have stayed at home in my bed to be cared for by my family. Sometimes I was fairly seriously ill. As a child I had poliomyelitis, which fortunately turned out not to be paralytic. I was frightened when I heard my mother and the doctor whispering in the hall outside my room. When I was living by myself and was ill, I usually stayed at home alone and was able to make soup and tea and to minister to myself, or perhaps someone looked in on me. I have also . . .
Comparison of rates of safety issues and reporting of trial outcomes for medical devices approved in the European Union and United States: cohort study
Authors: Thomas J Hwang, Elisaveta Sokolov, Jessica M Franklin, Aaron S Kesselheim
Journal: BMJ (2016)

<b>Objective</b>&nbsp;To evaluate safety alerts and recalls, publication of key trial outcomes, and subsequent US approval of high profile medical devices introduced in the European Union. <b>Design</b>&nbsp;Cohort study. <b>Setting</b>&nbsp;Novel cardiovascular, orthopedic, and neurologic devices approved in the EU through Conformité Européenne marking between 2005 and 2010. <b>Data sources</b>&nbsp;Public and commercial databases searched up to January 2016 for press releases and announcements of approvals; public Food and Drug Administration and European regulatory authority databases for US approvals and safety alerts and recalls; and Medline, Embase, and Web of Science for peer reviewed publications. <b>Main outcome measures</b>&nbsp;We categorized the novelty of the devices in the study sample as a “major innovation” or an “other change,” and extracted descriptive data about the devices and information on any safety alerts and withdrawals. Linear regression models examined factors associated with differential EU and US approvals. Cox proportional hazards regression models were used to evaluate factors associated with safety alerts and recalls and the publication of trial outcomes for devices categorized as major innovations. Models controlled for time, therapeutic category, regulatory pathway, size of sponsoring company, and indicator variables for devices approved first in the EU and devices approved only in the EU. <b>Results</b>&nbsp;67% (206/309) of devices identified were approved in both the US and the EU, of which 63% (129/206) were approved first in the EU. The unadjusted rate of safety alerts and recalls for devices approved first in the EU was 27% (62/232) compared with 14% (11/77) for devices approved first in the US. The adjusted hazard ratio for safety alerts and recalls was 2.9 (95% confidence interval 1.4 to 6.2) for devices approved first in the EU. The results of pivotal trials were published for 49% (37/75) of devices categorized as major innovations, with an overall publication rate of 37% five years after approval. <b>Conclusions</b>&nbsp;Devices approved first in the EU are associated with an increased risk of post-marketing safety alerts and recalls. Poor trial publication rates mean that patients and clinicians need greater regulatory transparency to make informed decisions about treatment.
Somatomedins
Authors: Lawrence S. Phillips, Rena Vassilopoulou-Sellin
Journal: New England Journal of Medicine (1980)

Regulation of Somatomedins and Somatomedin ActivityIn view of the original definition of somatomedins as growth hormone-dependent, it is not surprising that the concept of regulation by growth hormone has received much attention. However, it now appears that other factors are also important (Fig. 1), and that their influence may sometimes override that of growth hormone. In addition, somatomedins vary with age in normal subjects (Fig. 2). Young children have values comparable to those in adults with hypopituitarism, and levels rise during childhood, perhaps because of altered end-organ sensitivity. Changes with adolescence and aging appear to be minor but have . . .
Case 28-1967
Authors: William H. Baker, Benjamin Castleman
Journal: New England Journal of Medicine (1967)

Presentation of CaseA fifty-year-old man with known Hodgkin's disease was admitted to the hospital because of weakness, a cough and fever.He had been well until four and a half years previously, when he entered another hospital because of malaise, swelling of the neck and periodic episodes of mild fever lasting for a few days. Numerous nontender, firm, enlarged lymph nodes were found in the left anterior and posterior cervical regions; the liver and spleen were not enlarged. The hemoglobin was normal, and the white-cell count was 7000, with a normal differential count. X-ray films of the chest were . . .
Graft-versus-host disease prophylaxis with methotrexate/cyclosporine in children with severe aplastic anemia treated with cyclophosphamide and HLA-identical marrow grafts [letter]
Authors: R Storb, JE Sanders, M Pepe, C Anasetti, FR Appelbaum, CD Buckner, HJ Deeg, K Doney, J Hansen, P Martin
Journal: Blood (1991)
Hemodynamic effects of non-invasive ventilation in patients with obesity-hypoventilation syndrome
Authors: Olalla Castro-Añόn, Rafael Golpe, Luis A. Pérez-de-Llano, María J. Lόpez, Edgar Escalona, Ruth Pérez-Fernández, Ana Testa, Arturo González Quintela
Journal: European Respiratory Journal (2011)

Background: Although it was occasionally reported that pulmonary hypertension (PH) is more frequent in obesity-hypoventilation syndrome (OHS) patients than in “pure” obstructive sleep apnea syndrome (OSAS) patients, little is known about the haemodynamic repercussion of this entity. The aim of this study was to describe the hemodynamic situation -assessed by echocardiography and six-minute walking test (6MWT)- of patients newly diagnosed with the most severe form of OHS and to evaluate the impact of non-invasive ventilation (NIV) on it.

Methods: We conducted a prospective, descriptive, single-center follow-up study. At baseline, patients underwent echocardiography, spirometry, static lung volumes measurement, 6MWT, overnight pulse-oximetry and polygraphic recording. We assessed changes in echocardiographic findings and 6MWT after 6 months of NIV implementation. Right ventricular overload (RVO) was defined by the presence of right ventricular (RV) dilatation, RV hypokinesis, paradoxical septal systolic motion or/and PH.

Results: A total of 30 subjects (20 women; mean age: 69±11 years) were included. The percentage of patients with RVO did not change significantly after NIV (from 43.3% to 41.6%; p = 0.24). Pulmonary artery systolic pressure (PASP) for patients with RVO at diagnosis decreased significantly at 6 months (from 58±11 to 44±12 mmHg; p= 0.014) and the mean distance walked on the 6MWT increased from 350±110 to 426±78 m (p = 0.006) without significant changes in the body mass index.

Conclusions: PH is a frequent finding in patients with the most severe form of OHS. Treatment with NIV leads to a decrease in PASP and an increase in the distance covered during the 6MWT.
Serum Level Of Parathyroid Hormone Is Associated With Risk Factors and Clinical Outcomes In Multiple Myeloma
Authors: Min-Gu Kang, Min-Joong Jang, O-jin Lee, Min-Seok Heo, Hyun-Woo Choi, Hwan-Young Kim, Nguyen Thi Dai Trang, Deok-Hwan Yang, Je-Jung Lee, Jong-Hee Shin, Soon-Pal Suh, Dong-Wook Ryang, Hye-Ran Kim, Myung-Geun Shin
Journal: Blood (2013)
Integrating epigenomic data and 3D genomic structure with a new measure of chromatin assortativity
Authors: Vera Pancaldi, Enrique Carrillo-de-Santa-Pau, Biola Maria Javierre, David Juan, Peter Fraser, Mikhail Spivakov, Alfonso Valencia, Daniel Rico
Journal: Genome biology (2016)

Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin assortativity, to integrate the epigenomic landscape of a specific cell type with its chromatin interaction network and thus investigate which proteins or chromatin marks mediate genomic contacts. We use high-resolution promoter capture Hi-C and Hi-Cap data as well as ChIA-PET data from mouse embryonic stem cells to investigate promoter-centered chromatin interaction networks and calculate the presence of specific epigenomic features in the chromatin fragments constituting the nodes of the network. We estimate the association of these features with the topology of four chromatin interaction networks and identify features localized in connected areas of the network. Polycomb group proteins and associated histone marks are the features with the highest chromatin assortativity in promoter-centered networks. We then ask which features distinguish contacts amongst promoters from contacts between promoters and other genomic elements. We observe higher chromatin assortativity of the actively elongating form of RNA polymerase 2 (RNAPII) compared with inactive forms only in interactions between promoters and other elements. Contacts among promoters and between promoters and other elements have different characteristic epigenomic features. We identify a possible role for the elongating form of RNAPII in mediating interactions among promoters, enhancers, and transcribed gene bodies. Our approach facilitates the study of multiple genome-wide epigenomic profiles, considering network topology and allowing the comparison of chromatin interaction networks.
Use of medical cannabis to reduce pain and improve quality of life in cancer patients.
Authors: Jessica Cudmore, Paul Joseph Daeninck
Journal: Journal of Clinical Oncology (2015)

198 Background: Early attention to pain and symptoms in those with cancer improves both quality of life and survival. Opioid medications are the mainstay treatment of cancer-related pain. Cannabinoids are increasingly used as adjunctive treatments for cancer pain, but clinical evidence supporting their use as an “opioid sparing agent” or to improve quality of life is as yet unknown. Our study sought to determine if the addition of cannabinoids (medical cannabis) resulted in the reduction of the average opioid dose required for pain control, and improve self-reported quality of life indices. Methods: A retrospective chart review of cancer patients followed in our CCMB Pain and Symptom Clinic was conducted. Inclusion criteria: age over 18 years and formal enrollment in Health Canada’s Marihuana for Medical Purposes (MMPR) program (n = 24). Average dose of opioids were calculated in milligrams of morphine equivalent (ME) per day at the last documented visit prior to enrolment in the MMPR and then at the subsequent clinic visit. Averages of self-reported ESAS scores (pain, tiredness, drowsiness, nausea, appetite, depression, anxiety, sense of wellbeing) were calculated for the same visits. Statistical analysis using the paired student’s t-test compared means and determined the significance of any changes. Results: Following enrolment in the MMPR, the average opioid dose decreased by 70.375mg of MEs (p = 0.29). Self-reported ratings (10-point Likert scale) in pain (0.75, p = 0.23), tiredness (0.58, p = 0.21), drowsiness (1.125, p = 0.04), nausea (1.125, p = 0.04), appetite (1.42, p = 0.04), depression (1.29, p = 0.02) and anxiety (1.58, p = 0.004) improved after enrolment. Sense of wellbeing ratings did not change. Conclusions: Patients with cancer pain benefited from the addition of cannabinoids. The average opioid dose decreased following access to medical cannabis. Self-reported ratings of several quality of life indicators showed statistically significant improvement. Our study shows a signal that cannabinoids may reduce cancer patients’ reliance on opioids to control pain. Further prospective controlled studies are needed to further elucidate the role of cannabinoids in the treatment of cancer pain.