tbuckley/cabot-search huggingface dataset:
Erratum: Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
Authors: Padhraig Gormley, Verneri Anttila, Bendik S Winsvold, Priit Palta, Tonu Esko, Tune H Pers, Kai-How Farh, Ester Cuenca-Leon, Mikko Muona, Nicholas A Furlotte, Tobias Kurth, Andres Ingason, George McMahon, Lannie Ligthart, Gisela M Terwindt, Mikko Kallela, Tobias M Freilinger, Caroline Ran, Scott G Gordon, Anine H Stam, Stacy Steinberg, Guntram Borck, Markku Koiranen, Lydia Quaye, Hieab H H Adams, Terho Lehtimäki, Antti-Pekka Sarin, Juho Wedenoja, David A Hinds, Julie E Buring, Markus Schürks, Paul M Ridker, Maria Gudlaug Hrafnsdottir, Hreinn Stefansson, Susan M Ring, Jouke-Jan Hottenga, Brenda W J H Penninx, Markus Färkkilä, Ville Artto, Mari Kaunisto, Salli Vepsäläinen, Rainer Malik, Andrew C Heath, Pamela A F Madden, Nicholas G Martin, Grant W Montgomery, Mitja I Kurki, Mart Kals, Reedik Mägi, Kalle Pärn, Eija Hämäläinen, Hailiang Huang, Andrea E Byrnes, Lude Franke, Jie Huang, Evie Stergiakouli, Phil H Lee, Cynthia Sandor, Caleb Webber, Zameel Cader, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Johan G Eriksson, Veikko Salomaa, Kauko Heikkilä, Elizabeth Loehrer, Andre G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Lynn Cherkas, Linda M Pedersen, Audun Stubhaug, Christopher S Nielsen, Minna Männikkö, Evelin Mihailov, Lili Milani, Hartmut Göbel, Ann-Louise Esserlind, Anne Francke Christensen, Thomas Folkmann Hansen, Thomas Werge, Jaakko Kaprio, Arpo J Aromaa, Olli Raitakari, M Arfan Ikram, Tim Spector, Marjo-Riitta Järvelin, Andres Metspalu, Christian Kubisch, David P Strachan, Michel D Ferrari, Andrea C Belin, Martin Dichgans, Maija Wessman, Arn M J M van den Maagdenberg, John-Anker Zwart, Dorret I Boomsma, George Davey Smith, Kari Stefansson, Nicholas Eriksson, Mark J Daly, Benjamin M Neale, Jes Olesen, Daniel I Chasman, Dale R Nyholt, Aarno Palotie
Journal: Nature Genetics (2016)
What next for gatekeepers?
Authors: Sophie Cook
Journal: BMJ (2016)

Part of the burgeoning workload of GPs in the United Kingdom is being an NHS gatekeeper. Successful gatekeeping is a challenge, and poor decisions have consequences. Over-referral risks inappropriate use of resources, while under-referral risks potential harm and dissatisfaction among patients. Direct access to specialists may sound appealing: it could reduce GPs’ workload as well as widening patients’ access. But what would be the effect on secondary care?

This week Geva Greenfield and colleagues ask whether it’s time to rethink primary care’s gatekeeper role (doi:10.1136/bmj.i4803). They argue that “a …
Alcohol consumption in Europe is still cause for alarm despite decrease, says WHO
Authors: Anne Gulland
Journal: BMJ (2016)

A drop in alcohol consumption across Europe has not been accompanied by a fall in alcohol related deaths, a report by the World Health Organization has found.

In 1990 the average adult in WHO’s European region consumed 12 L of pure alcohol; by 2014 this figure had dropped to less than 11 L.1 The drop was largest in the Mediterranean region, where per capita consumption fell from 12 L in 1990 to 8 L in 2014. The western central region, which includes countries such as …
Transcatheter versus surgical aortic valve replacement in patients with severe aortic stenosis at low and intermediate risk: systematic review and meta-analysis
Authors: Reed A Siemieniuk, Thomas Agoritsas, Veena Manja, Tahira Devji, Yaping Chang, Malgorzata M Bala, Lehana Thabane, Gordon H Guyatt
Journal: BMJ (2016)

<b>Objective</b>&nbsp;To examine the effect of transcatheter aortic valve implantation (TAVI) versus surgical replacement of an aortic valve (SAVR) in patients with severe aortic stenosis at low and intermediate risk of perioperative death. <b>Design</b>&nbsp;Systematic review and meta-analysis <b>Data sources</b>&nbsp;Medline, Embase, and Cochrane CENTRAL. <b>Study selection</b>&nbsp;Randomized trials of TAVI compared with SAVR in patients with a mean perioperative risk of death &lt;8%. <b>Review methods</b>&nbsp;Two reviewers independently extracted data and assessed risk of bias for outcomes important to patients that were selected a priori by a parallel guideline committee, including patient advisors. We used the GRADE system was used to quantify absolute effects and quality of evidence. <b>Results</b>&nbsp;4 trials with 3179 patients and a median follow-up of two years were included. Compared with SAVR, transfemoral TAVI was associated with reduced mortality (risk difference per 1000 patients: −30, 95% confidence interval −49 to −8, moderate certainty), stroke (−20, −37 to 1, moderate certainty), life threatening bleeding (−252, −293 to −190, high certainty), atrial fibrillation (−178, −150 to −203, moderate certainty), and acute kidney injury (−53, −39 to −62, high certainty) but increased short term aortic valve reintervention (7, 1 to 21, moderate certainty), permanent pacemaker insertion (134, 16 to 382, moderate certainty), and moderate or severe symptoms of heart failure (18, 5 to 34, moderate certainty). Compared with SAVR, transapical TAVI was associated higher mortality (57, −16 to 153, moderate certainty, P=0.015 for interaction between transfemoral versus transapical TAVI) and stroke (45, −2 to 125, moderate certainty, interaction P=0.012). No study reported long term follow-up, which is particularly important for structural valve deterioration. <b>Conclusions</b>&nbsp;Many patients, particularly those who have a shorter life expectancy or place a lower value on the risk of long term valve degeneration, are likely to perceive net benefit with transfemoral TAVI versus SAVR. SAVR, however, performs better than transapical TAVI, which is of interest to patients who are not candidates for transfemoral TAVI. <b>Systematic review registration</b>&nbsp;PROSPERO CRD42016042879
Fibroblast-induced cytokine (fic) and monocyte chemoattractant peptide-2 (mcp-2), 2 new beta-chemokines, cause basophil histamine-release
Authors: P Forsythe, S Stafford, J Heinrich, R Bravo, Paul Proost, Jozef Van Damme, R Alam
Journal: Journal of Allergy and Clinical Immunology (1994)
P246 Should we Telephone Missed Asthma Appointments? A Follow-Up Evaluation of Four Years of Practice: Abstract P246 Table 1
Authors: Y Narang, B McDonough, M Ahmad, S Mault, C Dillon, H Burhan, NER Beveridge
Journal: Thorax (2015)

<h3>Introduction</h3> We have previously shown that telephone contact following missed asthma clinic appointments is a resource-intensive method of improving compliance in a relatively small group of patients.<sup>1</sup> Poor adherence to treatment leads to increased admissions and reduced quality of life. Reducing rates of missed appointments is a key efficiency target for service delivery for the hospital. <h3>Aim</h3> To evaluate the outcome of telephone contact following missed asthma clinic appointments in a larger data set. <h3>Methods</h3> We reviewed the outcomes of telephone contact with patients following a missed appointment at a difficult asthma clinic at an inner city hospital between 2011 and 2014. Difficult asthma is defined as ongoing symptoms despite level 4–5 treatment. Successful contact was defined as speaking to the patient or receiving a message. Unsuccessful contact describes when messages were left for patents but no response achieved. <h3>Results</h3> Between 2012 and 2014 (inclusive) 457 patients missed an appointment. We attempted to contact 324 patients. Successful contact was made with 112 patients; 50 then attended clinic. Contact was unsuccessful for 212 patients; 59 then attended clinic. Due to a lack of contact details, no contact was attempted in 133 patients; 31 then attended clinic subsequently. The relative increase in clinic attendance following contact was 1.95 when compared to the no contact group, and 1.6 compared to the unsuccessful contact group. Unsuccessful contact produced a relative increase of 1.2 compared to no attempted contact. <h3>Conclusion</h3> Telephoning patients following a missed asthma clinic appointment is relatively resource intensive method of doubling clinic attendance. In the unsuccessful contact group, telephone calls were frequently not answered or were voicemail messages were not responded to. Yet there does appear to be a small benefit in attendance rates in this group compared to the no contact group. Because the groups were not randomised confounding factors may be present. Services that provide prospective reminders and perhaps use a free text service may be more effective and less labour intensive. <h3>Reference</h3> 1 McDonough B, Mault S. Non-attendance at a difficult asthma clinic.<i> Nursing Times</i> 2013;<b>109</b>(16):2–14
Women have higher rates of mental disorders than men, NHS survey finds
Authors: Anne Gulland
Journal: BMJ (2016)

Women are more likely to have mental health problems than men, with young women at particularly high risk, the biggest survey of mental health disorder and treatment in England has found.

The Adult Psychiatric Morbidity Survey, conducted every seven years and based on interviews with a cross section of the general population aged 16 and over, found that one in six adults (17%) had a common mental disorder—one in five women (20.7%) and one in eight men (13.2%).1 Common mental disorders were classified as generalised anxiety disorder, depression (including mild, moderate, and severe), phobias, obsessive compulsive disorder, panic disorder, and non-specified disorder.

The prevalence of mental health problems has been growing since the survey was first undertaken in 1993. That year …
Initial Molecular Response At 3 Months Can Identify Three Groups Of Patients With Different Responses and Event-Free Survival At 36-Months Following Second-Generation Tyrosine Kinase Inhibitor Therapy In Imatinib-Resistant Chronic Myeloid Leukemia
Authors: Carla Boquimpani, Rony Schaffel, Daniel Graça, Camila Mesquita, Tania Silva Madeira, Danielle Peixoto, Patricia Wendling, Clarisse Lobo, Irene Biasoli, Nelson Spector
Journal: Blood (2013)
Incidence of unconventional infections (UC) in patients with acute myelogenous leukemia (AML) treated with clofarabine (CLO)-containing induction therapy.
Authors: R. Knoebel, A. R. McQuary, E. Estey, P. S. Becker
Journal: Journal of Clinical Oncology (2010)

6573 Background: Pathogens causing infection in patients with AML who have not received hematopoietic cell transplantation (HCT) have typically been limited to bacteria and fungi with only rare cases of viral or pneumocystis (PCP) associated infection. This presumably reflects the primary effect of AML on neutrophils and monocytes rather than on lymphocytes, and thus general immunity and the use of drugs that are not generally immunosuppressive. This situation may have changed with the introduction of fludarabine (FLU), and more recently its structural analog CLO, into AML therapeutics. FLU causes profound lymphocytopenia with resultant risk of viral infections. In vitro data has demonstrated CLO to be directly toxic to quiescent lymphocytes and macrophages. However, it is unclear whether this translates into an increased incidence of viral and/or PCP infection in AML patients given CLO. Methods: Patients with AML who received CLO-containing induction therapy between 1/2006 and 11/2009 were identified and their hospital records reviewed. Patients with prior HCT were excluded. Organisms were assumed to be pathogens if identified in diagnostic tests. Most patients received prophylaxis with oral levofloxacin, fluconazole, and acyclovir and were discharged once chemotherapy was completed. Results: 62 pts received CLO-containing induction therapy. The most common regimen (80%) was: CLO (25-35 mg/m2 daily X 5) + araC (2 g/m2 daily days 1-5) + GCSF (from day -1 until ANC recovery). Pts had received a median of 1 prior therapy. We identified 77 episodes in which patients received IV antibiotics. There were 26 bacterial, 10 aspergillus, 1 PCP, 2 CMV, 1 parainfluenza, and 1 nocardia infection(s). Conclusions: Infections in patients treated with CLO while primarily due to bacteria and fungi also include more UC. To test whether the incidence of the latter is higher than seen with regimens limited to anthracycline + ara-C ± FLU we are doing a similar retrospective comparison in patients with relapsed/refractory AML given these regimens. We will also present a multivariate analysis of risk factors (particularly treatment ± CLO) for UC in relapsed/refractory AML. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Genzyme
Immunomodulatory Agent Lenalidomide Enhances Antitumor Functions of Chimeric Receptor-Modified T Cells in Vitro and in Vivo
Authors: Otáhal Pavel, Dana Prukova, Vlastimil Král, Radek Jaksa, Lucie Lateckova, Petra Vockova, Barbora Svobodova, Marek Trneny, Pavel Klener
Journal: Blood (2014)
Pharmacokinetic and Pharmacodynamic Evaluation of a Biosimilar Rituximab in Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) Treated with R-CHOP (Rituximab, Cyclophosphamide, Adriamycin, Vincristine, Prednisolone).
Authors: Auro Viswabandya, P.V. Prashanthi, C. Nirmala Raju, Reena Rajsekhar, Vikram Mathews, Shivkumar Madki, Dhiraj Abhayankar, Rukmini Kethireddypally, Biju George, Mammen Chandy, Cartikeya Reddy, Alok Srivastava
Journal: Blood (2007)
Population-Based Incidence Rates of Cervical Intraepithelial Neoplasia in the Human Papillomavirus Vaccine Era
Authors: Vicki B. Benard, Philip E. Castle, Steven A. Jenison, William C. Hunt, Jane J. Kim, Jack Cuzick, Ji-Hyun Lee, Ruofei Du, Michael Robertson, Scott Norville, Cosette M. Wheeler
Journal: JAMA Oncology (2016)

A substantial effect of human papillomavirus (HPV) vaccines on reducing HPV-related cervical disease is essential before modifying clinical practice guidelines in partially vaccinated populations.
Maternal mortality varies sevenfold across the US, report finds
Authors: Michael McCarthy
Journal: BMJ (2016)

An analysis incorporating 60 different measures of health—ranging from infant and maternal mortality rates to access to neighborhood amenities, such as playgrounds, libraries, and community centers—has found that the health of women, children, and infants in the US varies greatly from state to state and between racial and ethnic groups.

The study, America’s Health Rankings Health of Women and Children Report 2016 , prepared by the non-profit United Health Foundation, found that, overall, states in the northeastern US were the healthiest for women, children, and infants, with Massachusetts being ranked first in the nation followed by three other New England states (Vermont, New Hampshire, and Connecticut) and the midwestern state of Minnesota. …
Multicenter, randomized trial of conversion to everolimus with calcineurin inhibitor minimization or discontinuation in liver transplant patients with renal impairment
Authors: Frederik Nevens, Martina Sterneck, Herald Metselaar, Jerome Dumortier, Emiliono Giostra, Karim Boudjema, Evaristo Varo, Paolo de Simone
Journal: Hepatology (2007)
P0789 : Effectiveness, safety and cost per SVR in GT4 hepatitis C patients treated with sofosbuvir-based therapies in real clinical practice: A Franco-German experience (SOFEX-4)
Authors: R. Pais, P. Buggisch, J. Moussalli, Y. Benhamou, H. Wedemeyer, T. Asselah, M. Bec, J. Schwarzbard, V. Ratziu, J. Petersen
Journal: Journal of Hepatology (2015)
Why do we shine lights in the eyes of conscious patients after head injury?
Authors: Jonathan Benger
Journal: BMJ (2016)

Pupil examination is a standard part of the neurological assessment of patients after head injury. The internationally recognised Advanced Trauma Life Support course teaches that Glasgow Coma Scale (GCS) score and pupillary responses should be assessed in all patients with head injuries.1 Similarly, the National Institute for Health and Care Excellence (NICE) recommends that, after initial assessment in the emergency department, a patient who is normally alert (with a GCS score of 15) after head injury should have their GCS and pupils assessed half hourly for two hours, then hourly for four hours, then two hourly thereafter.2

The rationale for pupillary assessment is that changes in pupil size and reaction can indicate a rise in intracranial pressure and can help to identify the location of …
A sector-based postimplant dosimetric comparison of sagittal and axial ultrasound-guided source placement during I-125 permanent prostate brachytherapy.
Authors: Ahamed Badusha Mohamed Yoosuf, Darren M. Mitchell, Monica M. Byrne, Margaret A. Flynn, Eoin Napier, Suneil Jain, Geraldine Workman
Journal: Journal of Clinical Oncology (2014)

262 Background: To use sector based pre- and postimplant dosimetric analysis to evaluate the effect of changes in implant technique in a developing I-125 permanent prostate brachytherapy program (PPB). Methods: 109 men treated with PPB were divided into two groups by implant technique. The first 50 patients (group 1) had needle-by-needle seed deposition under axial ultrasound (USS) guidance and subsequent 59 patients (group 2) having needle placement row-by-row then seed deposition under sagittal USS guidance. Twelve sector dose volume analysis of pre-implant ultrasound (US pre ) and postimplant CT (CT post ) study was performed in all cases. Individual sectors were created by dividing the cranio-caudal prostate into three equal lengths creating prostate base, midgland and apex. Each of these volumes was then divided into four axial sectors (right and left anterior, right and left posterior). The difference in the minimum dose delivered to 90% of prostate volume (D 90 ) and the prostate volume receiving 100%, 150%, and 200% of the prescribed dose (V 100 , V 150 , and V 200 ) was compared between both groups. Results: In both groups, the volume of prostate in sectors one through six (entire base and anterior midgland) were significantly larger on CT post when compared to equivalent sectors in US pre (p &lt; 0.001), conversely the volumes in sectors 11 and 12 (posterior apex) were significantly smaller (p =0.001). When comparing dosimetric parameters of all equivalent sectors in CT post of both groups, it was found that D 90 of sector seven and eight (posterior midgland) in Group 1 received increased dose leading to elevated dose to the rectum but was significantly reduced in Group 2 (p &lt; 0.01), which resulted in achieving the dose as planned in US pre . Prostate implant dosimetry was significantly improved in group 2 with a trend to increased equivalent dose between CT post and US pre to each sectors and significant decrease in V 150 and V 200 in majority of the sectors. Conclusions: The row-by-row technique under sagittal USS guidance significantly improved our post implant dosimetric parameters when compared to single needle source placement under axial USS guidance as assessed by 12 sector analysis.
Right ventricular recovery during follow-up is associated with improved survival in patients with chronic heart failure with reduced ejection fraction
Authors: Frank Lloyd Dini, Erberto Carluccio, Anca Simioniuc, Paolo Biagioli, Gianpaolo Reboldi, Gian Giacomo Galeotti, Claudia Raineri, Luna Gargani, Laura Scelsi, Giulia Elena Mandoli, Antonia Cannito, Andrea Rossi, Pier Luigi Temporelli, Stefano Ghio
Journal: European Journal of Heart Failure (2016)
Prophylaxis of Acute Gvhd Using Stromal Cell Therapy: Preliminary Results After Administration of Single or Multiple Doses of Multistem® in a Phase I Trial
Authors: Richard T. Maziarz, Timothy deVos, Carlos Bachier, Steven C. Goldstein, Jose F. Leis, Robert Perry, Robert Deans, Wouter J Van't Hof, Hillard M. Lazarus
Journal: Blood (2011)
Preoperative Systolic Strain Rate Predicts Postoperative Left Ventricular Systolic Function in Patients With Chronic Mitral Regurgitation: 18 Months Follow up Study
Authors: Anna Marciniak, George R Sutherland, Maciej Marciniak, Antonios Kourliouros, Bart Bijnens, Marjan Jahangiri
Journal: Circulation (2009)
A Novel Target of Histone Deacetylase Inhibitor, Involves in Mitochondria Membrane Protein Ubiquitination and Regulates Apoptosis.
Authors: Peng Wu, Yang Cao, Yuan Tian, Zhenya Hong, Lishi Sun, Lingli Gui, Yicheng Zhang, Ding Ma, Jianfeng Zhou
Journal: Blood (2007)
MM-005: A Phase 1, Multicenter, Open-Label, Dose-Escalation Study to Determine the Maximum Tolerated Dose for the Combination of Pomalidomide, Bortezomib, and Low-Dose Dexamethasone in Subjects with Relapsed or Refractory Multiple Myeloma
Authors: Paul G. Richardson, Craig C. Hofmeister, David Siegel, Sagar Lonial, Mohamad Zaki, Ye Hua, Sheetal Shah, Jianming Wang, Kenneth C. Anderson
Journal: Blood (2012)
Systematic review and indirect treatment comparison (ITC) of dabrafenib (Dab) and trametinib (Tram) versus first-line (1L) treatments for metastatic melanoma (MM).
Authors: Kunal Srivastava, Purnima Pathak, Mayur Amonkar, Ceilidh Stapelkamp, R. Suzanne Swann, Michelle Casey, Cheena Rana
Journal: Journal of Clinical Oncology (2013)

e20012 Background: In PhIII randomized controlled trials (RCTs), Dab and Tram have shown significant improvement in the primary endpoint of progression-free survival (PFS) as monotherapies vs dacarbazine (DTIC) in 1L patients (pts) with BRAF V600E+ MM. Overall survival (OS) in these studies was confounded by crossover of DTIC pts to active treatment (trt) upon disease progression. This study compares PFS and OS for Dab and Tram with other 1L MM trts. Methods: Embase, MEDLINE, CCTR, and conferences were systematically searched through 10/2012 for relevant RCTs. Comparators were DTIC, vemurafenib (Vem), and ipilimumab (Ipi). Using random-effects network meta-analysis, Dab and Tram were compared directly (D) vs DTIC and indirectly (I) vs Vem and DTIC+Ipi. Results: 48 studies (147 publications) met inclusion criteria; 4studies (1,603 pts) contributed data to current network meta-analysis.Both Dab and Tram showed statistically significant reduction in the risk of progression directly vs DTIC and indirectly vs DTIC+Ipi and comparable PFS indirectly vs Vem (no statistically significant difference). Dab and Tram also demonstrated a statistically nonsignificant but numerically lower hazard of death directly vs DTIC and indirectly vs Vem and DTIC+Ipi. Conclusions: Using ITC, 1L trt of MM with Dab and Tram monotherapies was statistically significantly better than DTIC and DTIC+Ipi for PFS, with comparable efficacy to Vem for PFS and OS. Results must be interpreted cautiously given methodological assumptions and immature OS data for Dab and Tram. H2H studies remain gold standard for comparing trts. [Table: see text]