tbuckley/cabot-search huggingface dataset:
Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study
Authors: Frank J. Wolters, Francesco U. S. Mattace-Raso, Peter J. Koudstaal, Albert Hofman, M. Arfan Ikram
Journal: PLoS Medicine (2016)

Orthostatic hypotension (OH) is a common cause of transient cerebral hypoperfusion in the population. Cerebral hypoperfusion is widely implicated in cognitive impairment, but whether OH contributes to cognitive decline and dementia is uncertain. We aimed to determine the association between OH and the risk of developing dementia in the general population.Between 4 October 1989 and 17 June 1993, we assessed OH in non-demented, stroke-free participants of the population-based Rotterdam Study. OH was defined as a ≥20 mm Hg drop in systolic blood pressure (SBP) or ≥10 mm Hg drop in diastolic blood pressure (DBP) within 3 min from postural change. We furthermore calculated within participant variability in SBP related to postural change, expressed as coefficient of variation. Follow-up for dementia was conducted until 1 January 2014. We determined the risk of dementia in relation to OH and SBP variability, using a Cox regression model, adjusted for age; sex; smoking status; alcohol intake; SBP; DBP; cholesterol:high-density lipoprotein ratio; diabetes; body mass index; use of antihypertensive, lipid-lowering, or anticholinergic medication; and apolipoprotein E genotype. Finally, we explored whether associations varied according to compensatory increase in heart rate. Among 6,204 participants (mean ± standard deviation [SD] age 68.5 ± 8.6 y, 59.7% female) with a median follow-up of 15.3 y, 1,176 developed dementia, of whom 935 (79.5%) had Alzheimer disease and 95 (8.1%) had vascular dementia. OH was associated with an increased risk of dementia (adjusted hazard ratio [aHR] 1.15, 95% CI 1.00-1.34, p = 0.05), which was similar for Alzheimer disease and vascular dementia. Similarly, greater SBP variability with postural change was associated with an increased risk of dementia (aHR per SD increase 1.08, 95% CI 1.01-1.16, p = 0.02), which was similar when excluding those who fulfilled the formal criteria for OH (aHR 1.08, 95% CI 1.00-1.17, p = 0.06). The risk of dementia was particularly increased in those with OH who lacked a compensatory increase in heart rate (within lowest quartile of heart rate response: aHR 1.39, 95% CI 1.04-1.85, p-interaction = 0.05). Limitations of this study include potential residual confounding despite rigorous adjustments, and potentially limited generalisability to populations not of European descent.In this population predominantly of European descent, OH was associated with an increase in long-term risk of dementia.
TCT-617 Role of aortic root phenotype in the rate of more-than-mild aortic regurgitation after Corevalve and Edwards-SAPIEN implantation
Authors: Ramon Rodriguez-Olivares, Lennart v Gils, John d Vries, Sander van Weenen, Peter De Jaegere, Nicolas M. Van Mieghem
Journal: Journal of the American College of Cardiology (2015)
Capecitabine (X) combined with vinorelbine (V) in Chinese patients (pts) with metastatic breast cancer (MBC)
Authors: B. Xu, L. Tian, Q. Wu, M. Zhou, H. Wang, Z. Tong, H. Li, L. Li, G. Hu, J. Shi
Journal: Journal of Clinical Oncology (2004)

741 Background: Breast cancer is one of the most common malignancies among Chinese women. X (Xeloda) monotherapy has consistently high activity with a favorable safety profile and its addition to docetaxel extends survival in MBC. V has activity in MBC and no overlap in safety profile with X. XV has response rates of 43–67% in MBC, but there are no data in Chinese pts. Methods: 50 pts were planned in this phase II trial conducted between Feb and Nov 2003. All women had prior anthracycline or taxane treatment and measurable (WHO) MBC, adequate Karnofsky PS, bone marrow, renal and hepatic functions. Pts received the recommended doses from phase I studies: X 1000 mg/m2 orally twice daily on days 1–14 and V 25 mg/m2 i.v. on days 1 & 8, every 3 weeks.Results: 36 pts are currently evaluable for safety and 23 for efficacy: median age 49 years (33–69); median Karnofsky PS 80 (range 70–90); most common sites of metastases were liver (47%), lung (44%), and lymph nodes (22%). Prior treatment included anthracyclines (67%), paclitaxel (36%), and docetaxel (28%). All pts received at least 2 cycles, 19 received 4 cycles and 6 have received 6 cycles of XV so far. Interim efficacy findings are shown in the table, with a 44% response rate (so far unconfirmed). Median progression-free and overall survivals have not yet been reached. The only grade 3/4 adverse events reported to date are leucopenia (22%, G3 14%, G4 8%), managed satisfactorily with G-CSF. All other adverse events were easily managed with dose adjustments and supportive therapies where required. Conclusions: XV is a highly active, well-tolerated and convenient regimen in pts with previously treated MBC. Phase III trials of this novel regimen are warranted to demonstrate the utility of adding V to standard X monotherapy. No significant financial relationships to disclose.
Identification of New Hematopoietic Minor Histocompatibility Antigen UTA2-1; Ready for Application in Antitumor Immunotherapy
Authors: Rimke Oostvogels, Monique C. Minnema, Maureen van Elk, Robbert M Spaapen, Debbie van Baarle, Eric Spierings, Henk M. Lokhorst, Tuna Mutis
Journal: Blood (2011)
Perigastric fluid collection after endoscopic sleeve gastroplasty
Authors: Sindhu Barola, Abhishek Agnihotri, Mouen Khashab, Vivek Kumbhari
Journal: Endoscopy (2016)

A 39-year-old woman with a body mass index (BMI) of 32 kg/m2 was evaluated for suitability for endoscopic management of her obesity. Because of her interest in a durable weight loss intervention, she elected to undergo an endoscopic sleeve gastroplasty (ESG). The procedural details have been described previously by Sharaiha et al. and Lopez Nava et al. [1] [2] [3]. In brief, the volume of the stomach is reduced by approximately 70 % using a full-thickness endoscopic suturing system (OverStitch; Apollo Endosurgery, Austin, Texas, USA) ([Fig. 1]).
THE RELATIVE REACTION WITHIN LIVING MAMMALIAN TISSUES
Authors: Peyton Rous, W. W. Beattie
Journal: The Journal of Experimental Medicine (1926)

The introduction into the blood stream of dilute hydrochloric acid or sodium carbonate in quantities not too great to be compatible with life results in marked alterations in the color of certain of the matrix tissues stainable in vivo with phthalein indicators. Connective tissue in its various forms, and tendon and cartilage all become relatively more acid or alkaline than the normal. The hue of the kidney cortex also changes, as might be expected from its functions. The pancreas and lymph nodes, on the other hand, appear unaffected even when the injection is pushed to the extreme; and the slight to negligible alterations in the hue of the liver may be due to changes in the color of the associated secretion. The matrix tissues just mentioned behave as if unable to maintain a reaction of their own; whereas the elements of the parenchymal organs would seem to make their own conditions even when so much acid or alkali has been injected as will lead to death of the animal. Injections of lactic acid are well tolerated and it is difficult to bring about alterations in the color of the phthalein-stained matrix tissues by means of them. Salt solution, and sugar in large amount cause no changes in color such as would indicate changes in reaction. The results with the various phthalein indicators are in close accord, attesting that the information these give under vital conditions is reliable.
Oxalobacter formigenes–Derived Bioactive Factors Stimulate Oxalate Transport by Intestinal Epithelial Cells
Authors: Donna Arvans, Yong-Chul Jung, Dionysios Antonopoulos, Jason Koval, Ignacio Granja, Mohamed Bashir, Eltayeb Karrar, Jayanta Roy-Chowdhury, Mark Musch, John Asplin, Eugene Chang, Hatim Hassan
Journal: Journal of the American Society of Nephrology (2016)

Hyperoxaluria is a major risk factor for kidney stones and has no specific therapy, although Oxalobacter formigenes colonization is associated with reduced stone risk. O. formigenes interacts with colonic epithelium and induces colonic oxalate secretion, thereby reducing urinary oxalate excretion, via an unknown secretagogue. The difficulties in sustaining O. formigenes colonization underscore the need to identify the derived factors inducing colonic oxalate secretion. We therefore evaluated the effects of O. formigenes culture conditioned medium (CM) on apical 14 C-oxalate uptake by human intestinal Caco-2-BBE cells. Compared with control medium, O. formigenes CM significantly stimulated oxalate uptake (&gt;2.4-fold), whereas CM from Lactobacillus acidophilus did not. Treating the O. formigenes CM with heat or pepsin completely abolished this bioactivity, and selective ultrafiltration of the CM revealed that the O. formigenes –derived factors have molecular masses of 10–30 kDa. Treatment with the protein kinase A inhibitor H89 or the anion exchange inhibitor 4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid completely blocked the CM-induced oxalate transport. Knockdown of the oxalate transporter SLC26A6 also significantly restricted the induction of oxalate transport by CM. In a mouse model of primary hyperoxaluria type 1, rectal administration of O. formigenes CM significantly reduced (&gt;32.5%) urinary oxalate excretion and stimulated (&gt;42%) distal colonic oxalate secretion. We conclude that O. formigenes –derived bioactive factors stimulate oxalate transport in intestinal cells through mechanisms including PKA activation. The reduction in urinary oxalate excretion in hyperoxaluric mice treated with O. formigenes CM reflects the in vivo retention of biologic activity and the therapeutic potential of these factors.
Exploring Boundaries for the Genetic Consequences of Assortative Mating for Psychiatric Traits
Authors: Wouter J. Peyrot, Matthew R. Robinson, Brenda W. J. H. Penninx, Naomi R. Wray
Journal: JAMA Psychiatry (2016)

Considerable partner resemblances have been found for a wide range of psychiatric disorders, meaning that partners of affected individuals have an increased risk of being affected compared with partners of unaffected individuals. If this resemblance is reflected in genetic similarity between partners, genetic risk is anticipated to accumulate in offspring, but these potential consequences have not been quantified and have been left implicit.The anticipated consequences of partner resemblance on prevalence and heritability of psychiatric traits in the offspring generation were modeled for disorders with varying heritabilities, population prevalence (lifetime risk), and magnitudes of partner resemblance. These models facilitate interpretation for a wide range of psychiatric disorders, such as autism, schizophrenia, and depression. The genetic consequences of partner resemblance are most pronounced when attributable to phenotypic assortment (driven by the psychiatric trait). Phenotypic assortment results in increased genetic variance in the offspring generation, which may result in increased heritability and population prevalence. These consequences add generation after generation to a limit, but assortative mating is unlikely to balance the impact of reduced fecundity of patients with psychiatric disorders in the long term. This modeling suggests that the heritabilities of psychiatric disorders are unlikely to increase by more than 5% from 1 generation of assortative mating (maximally 13% across multiple generations). The population prevalence will increase most for less common disorders with high heritability; for example, the prevalence of autism might increase by 1.5-fold after 1 generation of assortative mating (≥2.4-fold in the long term) depending on several assumptions.The considerable partner resemblances found for psychiatric disorders deserve more detailed interpretation than has been provided thus far. Although the limitations of modeling are emphasized, the anticipated consequences are at most modest for the heritability but may be considerable for the population prevalence of rare disorders with a high heritability.
Paclitaxel/carboplatin (PC) followed by twice daily chemoradiation (hfRT/PC) versus hfRT/PC followed by PC as induction to surgery in stage III non-small cell lung cancer (NSCLC): A randomized phase III trial of the Lung Cancer Study Group Mitteldeutschland
Authors: R. Bonnet, C. P. Schneider, T. G. Wendt, N. Presselt, R. P. Baum, M. Schmuecking, H. Gosse, D. Täuscher, W. Schuette, G. Laier-Groeneveld, K. M. Mueller
Journal: Journal of Clinical Oncology (2008)

7541 Background: In multimodal neoadjuvant therapy of stage III NSCLC, the potential impact of the sequencing of the different induction modalities on survival has not been evaluated. Methods: Patients (pts) with biopsy-proven stage III (PET obligatory) NSCLC were stratified (center/technical operability) and then randomized to (arm 1) 2–3 cycles paclitaxel 225 mg/m2 d 1 / carboplatin AUC 6 d 1, followed by hfRT at 1.5 Gy 2x/d (total 45 Gy) with concurrent paclitaxel 50 mg/m2 / carboplatin AUC 2 d 1, 8, 15 vs (arm 2) hfRT/PC followed by PC at identical dosages to arm 1, then restaging incl. PET and surgery. The primary (secondary) endpoint was median overall survival (mOS), the secondary endpoint was median progression-free survival (mPFS). Assuming a median survival advantage of 6 months (mo) for arm 2, 104 pts per arm would detect a difference with type I (type II) error ≤ 5% (20%). Results: 210 pts were randomized between 01/01 and 06/05, 207 were evaluable. Median follow-up was 35 mo. The pts were well balanced between treatment arms 1/2: 106/104 pts; stage IIIA 34%/39%; stage IIIB 64%/60%; primary technical operability 24%/23%; PS 0 19%/18%; PS 1 29%/29%. mOS was 543 vs 550 days (p=073). mPFS was 326 vs 343 days (p=0.86). mOS of Stage IIIA was 489 vs 775 days (p=0.14), of stage IIIB 594 vs 546 days (ns). Grade 3 and 4 nonhematologic toxicities were not significantly different between treatment arms, leukopenias were more frequent in arm 2 (8 vs 28 pts). Conclusions: The sequence of chemotherapy and chemoradiation as multimodal induction therapy before surgery has no impact on mOS or mPFS in Stage III NSCLC. In Stage IIIA there is, however, a trend favoring arm 2. Grade 3 and 4 leukopenias are more frequent in arm 2. No significant financial relationships to disclose.
TCT-19 Two-Year Clinical Outcome and Chest Pain in 1,811 All-Comer Patients, Treated for Bifurcated Versus Non-Bifurcated Lesions With Highly Deliverable Drug-Eluting Coronary Stents
Authors: Liefke C. van der Heijden, Marlies M. Kok, Peter W. Danse, Gillian A. Jessurun, Ming Kai Lam, Melvyn Tjon Joe Gin, Alexander Schramm, Gert van Houwelingen, Raymond Hautvast, Gerard C. Linssen, Marije M. Löwik, Maarten J. Ijzerman, Carine J. Doggen, Clemens von Birgelen
Journal: Journal of the American College of Cardiology (2015)
Wilms Tumor 1 (WT1) Gene Mutations Predict Poor Outcome in Adults with Cytogenetically Normal (CN) Acute Myeloid Leukemia (AML): A Cancer and Leukemia Group B (CALGB) Study.
Authors: Peter Paschka, Guido Marcucci, Amy S. Ruppert, Krzysztof Mrózek, Susan P. Whitman, Kati Maharry, Christian Langer, Claudia D. Baldus, Bayard L. Powell, Maria R. Baer, Andrew J. Carroll, Michael A. Caligiuri, Jonathan E. Kolitz, Richard A. Larson, Clara D. Bloomfield
Journal: Blood (2007)
Procedural Volume and Outcomes of Septal Reduction Therapies in Patients With Hypertrophic Obstructive Cardiomyopathy—Reply
Authors: Luke K. Kim, Dmitriy N. Feldman
Journal: JAMA Cardiology (2016)

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Final Report of a Phase I Study of Clofarabine Plus High Dose Melphalan as a Conditioning Regimen for Allogeneic Transplantation
Authors: Mark Kirschbaum, Anthony Selwyn Stein, Paul Frankel, Leslie Popplewell, Robert w Chen, Maria L Delioukina, Ryotaro Nakamura, David S. Snyder, Cynthia Slape, Christopher Ruel, Joel Conrad, Auayporn Nademanee, Stephen Forman
Journal: Blood (2010)
Emergence of Rituximab-Fludarabine Resistance Is Associated with Changes in CD20 Antigen Expression and Improved Response to Almetuzumab Therapy in Patients with Chronic Lymphocytic Leukemia (CLL).
Authors: Umeer Ashraf, Anjana N. Elefante, Raymond Cruz, Paul K. Wallace, Myron S. Czuczman, Francisco J. Hernandez-llizaliturri
Journal: Blood (2007)
MICROBIC VIRULENCE AND HOST SUSCEPTIBILITY IN PARATYPHOID-ENTERITIDIS INFECTION OF WHITE MICE
Authors: Leslie T. Webster, Ida W. Pritchett
Journal: The Journal of Experimental Medicine (1924)

White mice from the Rockefeller Institute breeding room fed on a McCollum complete diet, consisting of whole wheat (67.5 per cent), casein (15 per cent), milk powder (10 per cent), NaCl (1 per cent), CaCO(3)(1.5 per cent), and butter fat (5 per cent) are more resistant to mouse typhoid infection, mercury bichloride intoxication, and botulinus toxin than are similar mice fed on bread and pasteurized milk supplemented by an oatmeal and buckwheat mixture and dog biscuit.
TCT-461 Association of Peri-procedural Myocardial Infarction with Long-term survival in Patients Treated with Coronary Revascularization Therapy of Chronic Total Occlusion
Authors: Woo Jin Jang, Joo-Yong Hahn, Seung-Hyuk Choi, Jeong Hoon Yang, Young Bin Song, Hyeon-Cheol Gwon, Ju Hyeon Oh
Journal: Journal of the American College of Cardiology (2015)
TCT-72 Prevalence and Distribution of Obstructive Pelvic Arterial Lesions by Computed Tomographic Angiography in 476 Patients with Erectile Dysfunction: Implications for Endovascular Therapy
Authors: Tzung-Dau Wang, Wen-Jeng Lee, Wen-Jone Chen, Ming-Fong Chen
Journal: Journal of the American College of Cardiology (2015)
Romidepsin Induces Durable Responses in Patients with Relapsed or Refractory Angioimmunoblastic T-Cell Lymphoma (AITL)
Authors: Barbara Pro, Steven M. Horwitz, H. Miles Prince, Francine M. Foss, Lubomir Sokol, Matthew Greenwood, Dolores Caballero, Franck Morschhauser, Martin Wilhelm, Lauren Pinter-Brown, Swaminathan Padmanabhan Iyer, Andrei R. Shustov, Julie Wolfson, Barbara E Balser, Bertrand Coiffier
Journal: Blood (2014)
Lithium Treatment Potentiates Both in Vitro and in Vivo Retinoic Acid Efficacy in APL.
Authors: Fabien Zassadowski, Katka Pokorna, Nicolas Ferre, Laura Llopis, Oussama Chourbagi, Joel Poupon, Martine Chopin, Pierre Fenaux, Rose Ann Padua, Marika Pla, Christine Chomienne, Bruno Cassinat
Journal: Blood (2012)
Colorectal cancer
Authors: W. Hamilton, M. G. Coleman, G. Rubin
Journal: BMJ (2013)

How is colorectal cancer diagnosed?The rest of this article assumes patients who meet current NICE guidance are investigated, and concentrates on presentations that do not meet NICE guidelines. 4 It does not concern factors before presentation to medical care: there can be major delays from patients not recognising that their symptoms are important. 11We found no literature suggesting that colorectal cancers in patients under 40 present differently from those in older patients.Similarly, we found no primary care study of colorectal cancer symptoms in patients with inflammatory bowel disease.
Clinical Activity of Abemaciclib (LY2835219), a Cell Cycle Inhibitor Selective for CDK4 and CDK6, in Patients with Relapsed or Refractory Mantle Cell Lymphoma
Authors: Franck Morschhauser, Kamal Bouabdallah, Stephan Stilgenbauer, Catherine Thieblemont, Martin Wolf, Sophie de Guibert, Florian Zettl, Marjo Hahka-Kemppinen, David Xiaohui Wang, Patrick Brueck, Charles Caldwell, Richard Beckmann, Lawrence Gelbert, Damien Cronier, Ji Lin, Lily Li, Edward M. Chan, Michael Pfreundschuh, Martin Wilhem, Georg Hess
Journal: Blood (2014)
Dasatinib Shows Therapeutic Potential in the Murine Xenograft Model for TCF3 rearranged Acute Lymphoblastic Leukemia
Authors: Kyle Lenz, Sarah Thompson, Natalya A. Goloviznina, Jianya Huan, Dorian H LaTocha, Brian J. Druker, Jeffrey W. Tyner, Peter Kurre, Bill H Chang
Journal: Blood (2014)
TCT-274 Clinical Impacts Of Inhibition Of Renin-Angiotensin System In Patients With Acute Myocardial Infarction Who Underwent Successful Late Percutaneous Coronary Intervention
Authors: Hyukjin Park, Hyun Kuk Kim, Myung Ho Jeong, Keun-Ho Park, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn
Journal: Journal of the American College of Cardiology (2015)
TCT-245 The Randomized Physiologic Assessment of Thrombus Aspiration in Patients with Acute Myocardial Infarction with ST-segment Elevation (PATA STEMI) Trial: final results
Authors: Dejan Orlic, Miodrag C. Ostojic, Branko Beleslin, Milica Labudovic Borovic, Dejan Milasinovic, Milorad Tesic, Goran Stankovic, Milorad Zivkovic, Sinisa Stojkovic, Milan Nedeljkovic
Journal: Journal of the American College of Cardiology (2015)
Do most newly diagnosed advanced NSCLC patients need nutritional intervention?
Authors: N. Swinton, G. Kasymjanova, T. Steinberg, L. Lajeunesse, E. Dajczman, H. Kreisman, D. Small, J. S. Agulnik, J. Kawadoi, N. MacDonald
Journal: Journal of Clinical Oncology (2007)

9108 Background: Depletion of nutritional reserves and significant weight loss are commonly noted in patients (pts) with non-small cell lung cancer (NSCLC). The Patient Generated Subjective Global Assessment (PG-SGA) is a nutritional screening tool for cancer pts, recommended by the Oncology Network of Dietitians of Canada and the American Dietetic Association. The PG-SGA categorizes total scores into 4 ranges for nutritional triage: 0–1 requires no intervention, 2–3 requires education, 4 - 8 requires intervention by a dietitian, and =9 requires urgent symptom control and nutrition intervention. (Ottery, 2000). Methods: We determined the prevalence of malnutrition in 92 newly diagnosed advanced NSCLC pts (stages 3 / 4) in an outpatient clinic who had completed a baseline PG-SGA. We also investigated the association between CRP (an inflammatory marker which correlates with poor prognosis) and the PG-SGA. PG-SGA score was based on the sum of 4 subscales: symptoms, weight history, food intake and functional status. Results: 92 pts (M 48, F 44) aged 65 ±11 years were studied. 21 (23%) pts had a PG-SGA score of 0–3, 23 (25%) 4–8, and 48 (52%) of 9 or greater. The most common symptoms accounting for a high PG-SGA score were: no appetite 37 (40%), pain 27 (29%), constipation 26 (28%), feeling full 24 (26%), dry mouth 22 (24%) and taste changes 19 (21%). 51 (55%) pts lost 0–4.9% of their body weight in the past month, 17 (19%) had a weight loss of 5–9.9% and 24 (26%) had a weight loss =10 %. In pts with a PG-SGA score of 0–3 the median CRP was 7.0 mg/L (range: 0.7–66.0), in those with a score of 4–8 the median CRP was 41.8 mg/L (0.8–266.1) and in those with a score of =9 the median CRP was 18.5 mg/L (0.3–219.0) (p=0.02). Conclusion: At time of diagnosis, 77% of advanced NSCLC pts were in need of nutritional intervention; 52% required urgent intervention. The PG-SGA is a simple screening tool which should be incorporated into patient care in outpatient oncology clinics. No significant financial relationships to disclose.