tbuckley/cabot-search huggingface dataset:
THU0217 Safety of Infliximab Therapy in HbsAg Carriers with Rheumatoid Arthritis: A Prospective Study
Authors: L. Fang, Y. Pan, X. Guo, X. Guo, Z. Liao, Z. Lin, J. Gu
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Prevalence rate of hepatitis B virus (HBV) infection in China (13%) and many other developing countries are much higher than that in developed countries. When anti-TNF agents are more available and affordable in developing countries, the safety of anti-TNF therapy in terms of reactivation of hepatitis B infection needs more concern. No data from a prospective study focus on the use of TNF antagonists in patients with concurrent rheumatoid arthritis (RA) and HBV infection is available by now. <h3>Objectives</h3> To evaluate the influence of infliximab on reactivation of HBV infection in HBsAg carriers with RA. <h3>Methods</h3> In this 52 weeks observation, HBsAg carriers with active RA (DAS28&gt;5.1) despite failed combined treatment with MTX and other non-biological DMARD were enrolled. Patients must have normal liver function prior to the study. All patients received therapy with infliximab (5mg/kg) and a low dose concomitant MTX (10-12.5mg). Lamivudin were prescribed preventively regardless of individual viral load. Pre-existing NSAIDs and corticosteroids (a maximum prednisone-dose equivalent of 10 mg/day) were allowed. During the study, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and HBV viral load (polymerase chain reaction) were monitored every 4 weeks. Increased viral load and abnormal liver function were managed and monitored according to expert opinion. <h3>Results</h3> Nine female patients were recruited. At baseline, three patients (group 1) had increased viral load (4.3e4, 3.6e8, 5.6e5 copy/ml, respectively), and the other six patients (group 2) had normal viral load (&lt;100 copy/ml). Only one patient from group 2 discontinued infliximab at week 6 due to ineffectiveness. Reactivation of hepatitis B occurred in one patient from group 1. At week 28, the patient (baseline viral load 5.6e5) underwent a mild increase of both ALT and AST (69 and 58 IU/L, respectively). A elevated viral load (8.9e8) and a HBV YMDD mutant were also found. The infliximab treatment continued. After prescription of Adefovir (combined with the pre-existing Lamivudin), both liver enzyme and viral load decreased to normal range in 12 weeks and remained normal. In the other two patients from group 1 and all patients from group 2, no significant increase of AST/ALT or viral load was seen during the 52 weeks follow-up. <h3>Conclusions</h3> A aggressive Infliximab + MTX therapy may be a safe option for HBsAg carriers with DMARDs refractory RA. In order to reduce the risk of reactivation of hepatitis B infection, prophylaxis strategy with more effective anti-viral drugs is recommended. Large cohorts are highly needed to further evaluate the use of anti-TNF agents in patients with concurrent rheumatic diseases and different HBV infection status, including inactive and active infection. <h3>Disclosure of Interest</h3> None Declared
Abstract 3659: Mast cell interactions with T-regulatory cells determine the outcome of colon cancer
Authors: Khashayarsha Khazaie
Journal: Cancer Research (2011)

Abstract Mast cells (MCs) are a bone marrow-derived, long-lived, heterogeneous cellular population that act both as positive and negative regulators of immune responses. They are arguably the biggest chemical factory in the body, and influence other cells through both soluble mediators and cell to cell interaction. MCs are commonly seen in various tumors and have been attributed alternatively with tumor rejection or promotion properties. Tumor infiltrating MCs are derived both from sentinel resident MC progenitors as well as from recruited progenitor cells (1). MC directly influence tumor cell proliferation and invasion (2, 3), but also help shape the tumor microenvironment (1) and modulate immune responses to tumors. Best known for orchestrating inflammation and angiogenesis, the role of MCs in modulating adaptive immune responses has only recently attracted attention. MCs are responsible for expansion of lymph nodes, and recruitment of dendritic cells. MC mediate immune suppression by Treg but can also reverse suppressive properties of Treg (4) or convert Treg into TH17 pro-inflammatory cells The central role of MC in the control of innate and adaptive immunity endows them with the ability to tune the nature of host responses to cancer and ultimately determine the outcome of disease and fate of the cancer patient (5) (6). 1. Maltby S, Khazaie K, McNagny KM. Mast cells in tumor growth: Angiogenesis, tissue remodelling and immune-modulation. Biochim Biophys Acta. 2009;1796(1):19-26. PMCID: 2731828. 2. Strouch MJ, Cheon EC, Salabat MR, Krantz SB, Gounaris E, Melstrom LG, et al. Crosstalk between mast cells and pancreatic cancer cells contributes to pancreatic tumor progression. Clin Cancer Res. 2010;16(8):2257-65. 3. Cheon EC, Khazaie K, Khan MW, Strouch MJ, Krantz SB, Phillips J, et al. Mast cell 5-Lipoxygenase activity promotes intestinal polyposis in APCΔ468 mice. Cancer Research. 2010;(in press). 4. Gounaris E, Blatner NR, Dennis K, Magnusson F, Gurish MF, Strom TB, et al. T-regulatory cells shift from a protective anti-inflammatory to a cancer-promoting proinflammatory phenotype in polyposis. Cancer Res. 2009;69(13):5490-7. 5. Blatner NR, Bonertz A, Beckhove P, Cheon EC, Krantz SB, Strouch M, et al. In colorectal cancer mast cells contribute to systemic regulatory T-cell dysfunction. Proc Natl Acad Sci U S A. 2010;107(14):6430-5. PMCID: 2851977. 6. Colombo MP, Piconese S. Polyps Wrap Mast Cells and Treg within Tumorigenic Tentacles. Cancer Res. 2009. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3659. doi:10.1158/1538-7445.AM2011-3659
BIVALIRUDIN WITH PROVISIONAL GLYCOPROTEIN IIB/IIIA INHIBITORS COMPARED TO HEPARIN WITH PLANNED OR PROVISIONAL GLYCOPROTEIN IIB/IIIA INHIBITORS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION: NETWORK META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS
Authors: Tarpan R. Patel, Alexander Ivanov, Terrence Sacchi, John Heitner, Sorin Brener
Journal: Journal of the American College of Cardiology (2016)
P4-16-01: Proteomic Analysis of Patient Plasma Identifies Parathyroid Hormone Related Protein (PTHrP12-48) as a Potential Biomarker of Breast Cancer Bone Metastasis.
Authors: CL Washam, SD Byrum, K Leitzel, AM Suhail, A Lipton, LJ Suva
Journal: Cancer Research (2011)

Abstract Background: Bone metastasis is a devastating and often incurable phase of breast cancer progression that significantly compromises patient morbidity and mortality. Despite the well-characterized issues associated with tumor progression, there is currently no reliable method to detect or predict which patients have or are at increased risk for developing bone metastasis. In this study a validated plasma-based proteomic profile for the diagnosis of breast cancer bone metastasis was developed and a highly discriminatory protein component of the profile identified as a novel fragment of parathyroid hormone related protein (PTHrP). Materials and Methods: Plasma samples were collected from a total of 110 breast cancer patients. The training set consisted of 38 breast cancer patients with clinical evidence of bone metastasis and 38 with no evidence of a bone metastasis from time of diagnosis to clinical outcome. The independent validation cohort consisted of 34 breast cancer patients with an unknown bone metastasis classification. The training set was analyzed using surface enhanced laser desorption time-of-flight mass spectrometry (SELDI-TOF MS) and 13 discriminatory protein peaks that contributed to a homogeneous partitioning of the training set (n = 76) in multiple statistical, bioinformatics, and machine learning modeling scenarios were identified and used to construct a RandomForest classifier for the detection of breast cancer bone metastasis (sensitivity: 100%, specificity: 100%). Results: The diagnostic profile identified was then independently confirmed in a blinded fashion using the validation cohort (sensitivity: 97%; specificity: 82%). Importantly, the most discriminatory protein peak (m/z 4260.92 Da) in the plasma of bone metastasis patients was subsequently identified using specific immunodepletion, tryptic peptide mapping and peptide sequencing as a unique proteolytic PTHrP fragment, PTHrP(12-48). Ongoing studies are determining the biogenesis and biological activity of this unique PTHrP peptide. Discussion: Our discovery of PTHrP(12-48) as a novel plasma biomarker of breast cancer bone metastasis validates our plasma proteomic approach and provides the first direct evidence for the existence of a circulating PTHrP biomarker in breast cancer patient plasma that is associated with bone metastasis. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-16-01.
Intermediate representations exclude embodiment
Authors: Guy Dove
Journal: Behavioral and Brain Sciences (2013)

Abstract Given that Pickering &amp; Garrod's (P&amp;G's) account integrates language production and comprehension, it is reasonable to ask whether it is compatible with embodied cognition. I argue that its dependence on rich intermediate representations of linguistic structure excludes embodiment. Two options are available to supporters of embodied cognition: They can adopt a more liberal notion of embodiment or they can attempt to replace these intermediate representations with robustly embodied ones. Both of these options face challenges.
P5-10-02: Relevance of Magnetic Resonance Imaging To Predict Disease-Free Survival after Neoadjuvant Chemotherapy of Breast Cancer.
Authors: CE Loo, Peeters M-JTFD Vrancken, J Wesseling, KGA Gilhuijs
Journal: Cancer Research (2011)

Abstract Purpose: To explore the relevance of magnetic resonance imaging (MRI) to predict disease free survival (DFS) after neoadjuvant chemotherapy (NAC) of breast cancer. Patients and Methods Between July 2000 and December 2007, MRI examinations were performed in 188 women before, during and after NAC in the context of a single-institution review board approved study. Patients were consecutively included after informed consent. Interpretation of MRI was revised by an experienced breast MR radiologists and included assessment of lesion morphology, changes in morphology, size, and contrast uptake kinetics (initial and late enhancement). MRI features and known prognostic markers of breast cancer (age, tumor response at pathology, tumor size at baseline, immunohistochemistry-derived breast cancer subtype (triple-negative; HER2−positive or ER-positive/HER2−negative)) were correlated with DFS. Multivariate Cox regression analysis was used with forward LR feature selection. Kaplan Meier curves were obtained to explore the impact of relevant associations. Results: Follow-up data were available of 184 women. The median follow-up time was 57,6 months (range 32,4 — 125). In 30 women events were found (26 breast cancer related deaths; 29 distant metastasis and 12 local/regional recurrences). At multivariate analysis, only breast cancer subtype (p=0.004) and largest diameter of late enhancement at MRI after NAC (p=0.006) retained prognostic value in favour of response at final pathology, age and tumor size at baseline. Cumulative survival at 60 months (kaplanmeier curves) was 70%, 86.7%, and 89.7% for triple-negatives, HER2−positive and ER-positive/HER2−negative subtypes [figure 1], respectively, and 88.5%, 81.4 % and 55.1% for absence of washout/plateau after NAC, between 0 and 30 mm washout/plateau, and ≥ 30 mm washout/plateau, respectively [figure 2]. Conclusions MRI after NAC in conjunction with breast cancer subtype has potential as complementary predictor for DFS. Larger diameters of residual late enhancement at MRI after NAC are associated with inferior DFS at 60 months. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-10-02.
SAT0524 Automated Breast Volume Scanner (ABVS), a New Automated Ultrasonic Device, is Useful to Examine Joint Injury in Patients with Rheumatoid Arthritis
Authors: S.-Y. Kawashiri, T. Suzuki, Y. Nakashima, Y. Horai, A. Okada, N. Iwamoto, K. Ichinose, M. Tamai, K. Arima, H. Nakamura, T. Origuchi, M. Uetani, K. Aoyagi, K. Eguchi, A. Kawakami
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Automated Breast Volume Scanner (ABVS) is an ultrasonic device to be developed for the automated scanning for mammary glands. ABVS is able to scan mammary gland automatically in a short time. <h3>Objectives</h3> We have tried to explore the clinical application of ABVS toward the synovial lesion in patients with rheumatoid arthritis (RA). <h3>Methods</h3> Thirteen active RA patients of mean 53 y.o., whose median disease duration 24 months and DAS28-ESR 6.02, were recruited. Patients gave their informed consent to be subjected to the protocol that was approved by the Institutional Review Board of Nagasaki University. We have examined total 130 metacarpophalangeal (MCP) joints as well as 26 wrist joints at dorsal sites by both ABVS (ACUSON S2000) and conventional ultrasonography (US) at the same day consecutively. ABVS was scanned in a water tank. Presence of synovial hypertrophy and bone erosion by gray-scale were examined by both methods, and the association of both methods was calculated by kappa coefficient. <h3>Results</h3> The scanning time of ABVS was 2 min per patient and that of conventional US was 15 min per patient, respectively. ABVS detected synovial hypertrophy in 23 MCP joints and 20 wrist joints whereas conventional US detected synovial hypertrophy in 18 MCP joints and 20 wrist joints. Kappa coefficient of synovial hypertrophy was 0.80 in MCP joints and 1.00 in wrist joints, respectively. ABVS detected bone erosion in 8 MCP joints and 12 wrist joints whereas conventional US detected bone erosion in 5 MCP joints and 11 wrist joints. Kappa coefficient of bone erosion was 0.76 in MCP joints and 0.92 in wrist joints, respectively. <h3>Conclusions</h3> Present data have shown a substantial agreement of ABVS with conventional US to find the synovial hypertrophy and bone erosion of wrist and finger joints in patients with RA. Since ABVS is able to scan the wrist and finger joints automatically in a short time, ABVS is a helpful new ultrasonic method to examine joint injury in patients with RA. <h3>References</h3> Kawashiri SY, et al. The power Doppler ultrasonography score from 24 synovial sites or 6 simplified synovial sites, including the metacarpophalangeal joints, reflects the clinical disease activity and level of serum biomarkers in patients with rheumatoid arthritis. Rheumatology (Oxford) 2011; 50: 962-5. Kawashiri SY, et al. Musculoskeletal ultrasonography assists the diagnostic performance of the 2010 classification criteria for rheumatoid arthritis. Mod Rheumatol. 2013;23:36-43. <h3>Acknowledgements</h3> n.p. <h3>Disclosure of Interest</h3> None Declared
FRI0454 Hand function in systemic sclerosis: Effect of occupational therapy on the health status and quality of life
Authors: K. Stefanantoni, S. Iliana, N. Iannace, D. D’Aluisio, L. Maset, L. Passi, M. Vasile, A. Scarno, A. Spadaro, V. Riccieri
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Hand involvement highly influences the activities of daily life in most patients with Systemic Sclerosis (SSc). Occupational therapy (OT) studies have rarely investigated for improving of hand function. <h3>Objectives</h3> To evaluate the effectiveness after one and three month of OT, based on a self-administered stretching program directed to maximize the hand performance during the activities of daily life using interview-based and self-administered questionnaires to assess hand function. <h3>Methods</h3> We enrolled 13 consecutive ScS patients, all female (mean age =62.8 yrs; mean disease duration =14.2 yrs) presenting a clinically evident hand involvement, characterized by pain and reduced range of motion. All patientshad a detailed clinical and laboratory assessment and their organ involvement was also investigated. All patients were evaluated by Canadian Occupational Performance Measure (COPM), with Duruoz Hand Index (DHI), HAQ and mental and physical SF36, at baseline, one and three months after having received instructions to finalize their activities on a self-administred stretching program. <h3>Results</h3> Eight (61,5%) patients had a diffuse form of SSc, while 5 (38,5%) had a limited form. All of them (100%) were ANA positive: 5 (38.5%) had anti-centromere and 5 (38.5%) had anti-topoisomerase I antibodies. Six (46%) patients had a modified Rodnan skin score over 14; digital ulcers were found in 5 (38.5%) cases. At the end of the one-month stretching program, there was a global improvement in the mean values of COPM performance (5,4 vs 6,32) (p=0,003) and satisfaction (6 vs 6,49) (p=0,04) and of total DHI (36 vs 29,3) (p=0,09). Mean values of HAQ assessment (1.71 vs 1.38) (p&lt;0.01) and of mental (33.68 vs 41.03) (p&lt;0.008) and physical (28.92 vs.31.75) SF36 scores also improved. The clinical benefit was confirmed after three month for COPM performance (5,4 vs 6,3) as well as for COPM satisfaction (6 vs 6,6) (p=0,06), for total DHI (36 vs 30) (p=0,08), for HAQ assessment (2,0 vs 1,3) (p=0,007), and for mental (33,68 vs 43,3) and physical (28,92 vs 29,3) (p=0,007) SF36 scores. <h3>Conclusions</h3> Our preliminary results show how successful OT together with stretching exercises of the hands can be on the health status and the emotional and physical personal perception of finger joint motion, thus improving quality of life and overall hand function in SSc patients. <h3>References</h3> Mugii N et al. J Rheumatol 2006; Mancuso T et al. J Hand Ther 2009;Poole JL Curr Op Rheumatol 2010. <h3>Disclosure of Interest</h3> None Declared
European Cancer Information Services Move to Unify Standards
Authors: K. Vaucrosson
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article European Cancer Information Services Move to Unify Standards Get access Karen Vaucrosson Karen Vaucrosson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 10, 20 May 1992, Page 756, https://doi.org/10.1093/jnci/84.10.756 Published: 20 May 1992
More teamwork needed to improve patient care MPs expose Quarry House "disaster" Hospitals told not to close emergency departments BMA calls for confidential firearms hotline Rural pharmacists win test case BMA rejects terms for public health registrars
Authors: L. Beecham
Journal: BMJ (1996)

# More teamwork needed to improve patient care {#article-title-2}

Surgical operations should not be started unless care services are available, and hospitals admitting urgent and emergency cases must have staffed operating theatres available on a 24 hour basis. This is one of the recommendations of the fifth report by the National Confidential Enquiry into Perioperative Deaths, which looked at 20 000 deaths occurring between April 1993 and March 1994.

The report says that there is still room for improvement in consultation, collaboration, and teamwork between anaesthetists, surgeons, and physicians. It emphasises the importance of better communication between the medical specialties involved, and urges clinicians, pathologists, and coroners to improve their working relationships.

The report recommends that protocols for treating common conditions should be applied more widely to elective and emergency admissions; the perioperative management of the elderly and unfit should be improved; trusts should implement systems to improve the retention and availability of all notes and records of clinical activity; and there should be more research on thromboembolism prophylaxis.

The chairman of the inquiry, Professor John Blandy, said that the number of deaths had to be balanced against the 3.5m operations performed each year. “There has been a quite noticeable improvement since we started these reports in 1987.”

More than 400 of the cases analysed involved elderly people with a broken thighbone. The report cites 10 cases in which its advisers “doubted the wisdom of the decision to operate.” In each case the patient …
PMO-062 Nutrition support infrastructure in the East of England—Anglia nutrition network (ANNET)
Authors: J Woodward, I Fellows, A Cartwright
Journal: Gut (2012)

<h3>Introduction</h3> ANNet—the Anglia Nutrition Network—was established in 2011 to provide a forum for inter-professional communication, sharing good practice and innovations across the Anglian region in order to improve the quality and experience of all aspects of nutritional care. 17 secondary acute hospital trusts participate in the network which looks after a population of approximately six million. This survey reports on the nutrition team infrastructure within the network. <h3>Methods</h3> ANNet was established with a formal constitution voted at the inaugural Annual General Meeting in September 2011. Among the first activities of ANNet was a description of the nutrition infrastructure in the region. This first “5 min survey” was disseminated among lead clinicians participating in the network in order to develop a snapshot of in hospital parenteral nutrition practice. <h3>Results</h3> The response rate was 100% of the 17 Trusts participating in the network. 15/17 Trusts have a nutrition support team but of these three had no nutrition support nurse specialists and 4 had no allocated consultant time. 13 teams were led by a gastroenterologist, one by a nurse and one by a chemical pathologist. 7/15 teams see patients on parenteral nutrition twice or less each week, and 6/15 carry out daily ward rounds. 10/17 Trusts provide out of hours PH, but only five of these with vitamins and trace elements and 5/17 are able to compound from scratch. A snapshot revealed 88 patients on PN at the time of the survey (14/million), of which 72% were type I intestinal failure, 18% type II and 10% type III. The median number of patients receiving PN was four, with only three Trusts providing PN for more than five patients at the time of the survey—two with seven (one of which did not have a nutrition support team) and one Trust with 26, providing 30% of the region9s PN. <h3>Conclusion</h3> Compared to national figures, a higher proportion of Trusts in the region have a nutrition support team, although in many instances this is incompletely staffed. There are a relatively small number of patients receiving PN at any one time in any Trust, but a surprisingly high proportion of these have type II intestinal failure which are currently scattered around the region. ANNet is a useful resource for gathering information with a 100% response from participating Trusts in the network, covering approximately 10% of the UK population. A follow-up survey will focus on intestinal failure surgery. <h3>Competing interests</h3> None declared.
QT or Not QT?
Authors: Sami Viskin, Roman Fish, Arie Roth, Peter J. Schwartz, Bernard Belhassen
Journal: New England Journal of Medicine (2000)

A 35-year-old woman was referred to the arrhythmia clinic because of palpitations and a finding of ventricular extrasystoles on a Holter recording. She had no history of heart disease, and her electrocardiogram (Figure 1) and echocardiogram were interpreted as normal.Extrasystoles are common in otherwise healthy young patients. For the majority, this is a harmless condition that does not require therapy. However, the rare patient who is at risk for lethal arrhythmias must be identified. The fact that the echocardiogram is normal is the most consequential information, because arrhythmias are generally benign in the absence of heart disease. . . .