tbuckley/cabot-search huggingface dataset:
Abstract 9290: Clinical, Electrocardiographic, and Genetic Characteristics of Patients with Idiopathic Ventricular Fibrillation Associated with Early Repolarization
Authors: Hiroshi Watanabe, Akihiko Nogami, Kimie Ohkubo, Takeru Makiyama, Yuka Hayashi, Toshio Shimada, Satomi Nagao, Nobue Yagihara, Naofumi Takehara, Yuichiro Kawamura, Akinori Sato, Kazuki Okamura, Masaomi Chinushi, Yukio Hosaka, Masahito Sato, Satoki Fukae, Hirotaka Oda, Masaaki Okabe, Koji Maemura, Minoru Horie, Ichiro Watanabe, Yoshifusa Aizawa, Naomasa Makita
Journal: Circulation (2011)

Background: Early repolarization or J-wave has generally been considered benign for decades. However, we and others recently reported that early repolarization is associated with idiopathic ventricular fibrillation (VF). This study aimed to investigate its clinical and genetic characteristics and to identify risk factors for arrhythmia events. Methods and results: This study included 38 patients (32 men; age, 42±17 years) with idiopathic VF associated with early repolarization. All of the patients had arrhythmia events. The events occurred during sleeping (n=12) or at rest (n=9) in more than half of the patients. An electrical storm defined as ≥3 episodes of VF during 24 hours was observed in 8 patients (21%). A family history of sudden cardiac death was reported in 7 patients (18%). In 12-lead electrocardiograms, early repolarization was present in the inferior leads in 9 patients, in the lateral/precordial leads in 12 patients, and in both of the inferior and lateral/precordial leads in the remaining 17 patients. Conduction disease, mostly prolongation of PR interval, was present in 13 patients (34%). The heart rate was slower, and the PR interval and QRS duration were longer in patients with idiopathic VF compared to 190 age- and sex-matched healthy controls. VF was inducible by programmed electrical stimulation in 15 of 27 patients (55%). We identified loss-of-function mutations in SCN5A in 3 unrelated patients, and interestingly, His-ventricular interval was prolonged in all of them. During a follow-up of 6.0±5.7 years, VF recurred in 9 patients. Multivariate analyses revealed that a family history of sudden cardiac death and a history of electrical storm were associated with increased risk of arrhythmia recurrences. The age of arrhythmia onset, gender, lead location of early repolarization, activity at the initial event, conduction disease, or inducibility of VF were not associated with the risk of recurrences. Conclusions: This study showed the clinical and genetic characteristics of idiopathic VF associated with early repolarization, suggesting the underlying mechanism for arrhythmia susceptibility. Our data may be useful for risk stratification for arrhythmia events.
Comparison of the European Union Disease Surveillance Networks’ websites
Authors: A Lenglet, G Hernández Pezzi
Journal: Eurosurveillance (2006)

Currently the surveillance of infectious disease in the European Union (EU) is supported by the Basic Surveillance Network (BSN) and other disease specific surveillance networks (DSNs). Each network has its own website. The objective of the current study was to describe the information presented with public access on each website from the perspective of its usefulness for the surveillance of an EU member state. The BSN and the DSNs cited in Decision 2003/542/CE were included. Each website was reviewed and assessed on the inclusion of characteristics from three broad categories: 1) general information, 2) procedures for data collection and 3) data presentation. Ten surveillance network websites were reviewed during the week of 5 December 2005. At least 80% of the 10 networks included a list of participating countries, the contact addresses for the coordinator of the network and the participating country gatekeepers and the network and #39;s objectives. Only one network specified the source and coverage of the data of each country on its website, and seven presented the disease case definition. Raw data were shown on eight websites and only two networks included presentation of elaborated data for the whole of the EU. Four networks included no reports on their websites. The periodicity of presentation for both raw data and elaborated data varied greatly between networks. The publicly available information on the 10 network websites studied was not homogeneous. We recommend that all networks present a basic set of characteristics on their websites, including case definitions, procedures used for data collection and periodic reports covering elaborated data for the entire EU.
Roles of Supplementary Motor Areas in Auditory Processing and Auditory Imagery
Authors: César F. Lima, Saloni Krishnan, Sophie K. Scott
Journal: Trends in Neurosciences (2016)

Although the supplementary and pre-supplementary motor areas have been intensely investigated in relation to their motor functions, they are also consistently reported in studies of auditory processing and auditory imagery. This involvement is commonly overlooked, in contrast to lateral premotor and inferior prefrontal areas. We argue here for the engagement of supplementary motor areas across a variety of sound categories, including speech, vocalizations, and music, and we discuss how our understanding of auditory processes in these regions relate to findings and hypotheses from the motor literature. We suggest that supplementary and pre-supplementary motor areas play a role in facilitating spontaneous motor responses to sound, and in supporting a flexible engagement of sensorimotor processes to enable imagery and to guide auditory perception.
Expression Of Nitric Oxide Synthase, Vascular Cell Adhesion Molecule and C- Reactive Protein Receptor In Sickle Cell Leucocytes: Relationship With Chronic Inflammation
Authors: Wendell Vilas Boas, Bruno A. V. Cerqueira, Thassila Nogueira Pitanga, Sanzio Silva Santana, Joao Oliveira Reis, Marilda Souza Goncalves
Journal: Blood (2013)
Use of cystatin C as a biomarker for glomerular filtration rate in patients with head and neck cancer receiving cisplatin-based chemotherapy.
Authors: E. Boelke, G. Schieren, W. Budach, C. Matuschek, M. Peiper, S. Gripp, G. Steinbach, M. Pelzer, C. Antke, D. Hermsen
Journal: Journal of Clinical Oncology (2010)

5592 Background: Determination of renal function is a prerequisite for planning therapy in cancer patients. Limitations of creatinine as marker for the glomerular filtration rate (GFR) led to the proposal of cystatin C as a more accurate biomarker especially in mild renal insufficiency or in patients with low muscle mass. We compared the accuracy of cystatin C- and creatinine-based equations to estimate GFR in patients with head and neck cancer (HNC) receiving platinum based chemotherapy. Methods: The study population consisted of 50 HNC patients (GFR range 37-105 mL/min/1.73 m2), complemented by 19 patients with known renal insufficiency (GFR range 10-60 mL/min/1.73 m2). Intra-class correlation coefficients were calculated between the reference method (51)Cr-EDTA clearance and estimated GFR by creatinine clearance and equations based on creatinine (Cockroft-Gault, Modified-Diet-in-Renal-Disease, Wright) or cystatin C (Larsson, Dade- Behring, Hoek). Additionally, sensitivity and specificity to discriminate GFR < 60 mL/min/1.73 m2 were evaluated by receiver-operating- characteristic-curve (ROC). Results: The highest correlation coefficients were found for the cystatin C-based estimates in comparison with creatinine-based estimates or creatinine clearance, even though Bland-Altman plots revealed GFR overestimation for all equations tested. The cystatin C-based Hoek formula exhibited the highest overall precision and accuracy. GFR of > 60 mL/min/1.73 m2 was assumed as cut-off for chemotherapy, ROC analyses revealed the highest AUC for the creatinine-based Wright formula, closely followed by modified diet in renal disease formula and cystatin C-based equations of Larsson, Dade-Behring and Hoek. Conclusions: Cystatin C-based GFR estimates showed the over-all strongest correlation to the reference method. Thus, we recommend cystatin C for GFR estimation in HNC patients as alternative method to the estimated creatinine clearance in clinical practice to avoid nephrotoxicity in patients receiving platinum based chemotherapy. No significant financial relationships to disclose.
Health Care Use and HIV Testing of Males Aged 15–39 Years in Physicians’ Offices — United States, 2009–2012
Authors: D. Cal Ham, Ya-lin Huang, Roman Gvetadze, Philip J. Peters, Karen W. Hoover
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

In 2014, 81% of new human immunodeficiency virus (HIV) infection diagnoses in the United States were in males, with the highest number of cases among those aged 20-29 years. Racial and ethnic minorities continue to be disproportionately affected by HIV; there are 13 new diagnoses each year per 100,000 white males, 94 per 100,000 black males, and 42 per 100,000 Hispanic males (1). Despite the recommendation by CDC for HIV testing of adults and adolescents (2), in 2014, only 36% of U.S. males aged ≥18 years reported ever having an HIV test (3), and in 2012, an estimated 15% of males living with HIV had undiagnosed HIV infection (4). To identify opportunities for HIV diagnosis in young males, CDC analyzed data from the 2009-2012 National Ambulatory Medical Care Survey (NAMCS) and U.S. Census data to estimate rates of health care use at U.S. physicians' offices and HIV testing at these encounters. During 2009-2012, white males visited physicians' offices more often (average annual rate of 1.6 visits per person) than black males (0.9 visits per person) and Hispanic males (0.8 visits per person). Overall, an HIV test was performed at 1.0% of visits made by young males to physicians' offices, with higher testing rates among black males (2.7%) and Hispanic males (1.4%), compared with white males (0.7%). Although higher proportions of black and Hispanic males received HIV testing at health care visits compared with white males, this benefit is likely attenuated by a lower rate of health care visits. Interventions to routinize HIV testing at U.S physicians' offices could be implemented to improve HIV testing coverage.
Interaction Between 5-FluorouraciI, [6RS]Leucovorin, and Recombinant Human Interferon-α2a in Cultured Colon Adenocarcinoma Cells
Authors: J A Houghton, D A Adkins, A Rahman, P J Houghton
Journal: Cancer Communications (1991)

Recombinant human interferon-alpha 2a (rIFN-alpha 2a; 500 or 5,000 IU/mL) or [6RS] leucovorin ([6RS]LV; 1 microM) each potentiated the cytotoxic activity of 5-fluorouracil (FUra) by 2.6- to 3.2-fold during 72 hr exposures in two human colon adenocarcinoma cell lines (GC3/c1; VRC5/c1). When all three agents were combined, FUra cytotoxicity was further potentiated by 3.2- to 4.3-fold (total 10- to 14-fold). Potentiation of FUra cytotoxicity occurred at clinically achieveable concentrations of rIFN-alpha 2a and [6RS]LV. Effects were reversed by dThd (20 microM), although the activity of CB3717, a quinazoline-based, specific inhibitor of thymidylate synthase, was not potentiated by rIFN-alpha 2a. Data suggest the requirement of a 5-fluoropyrimidine for biochemical modulation and interaction at the level of thymidylate synthase or DNA.
“Vote for Me”
Authors: Hunter Groninger, Anne Kelemen, George Ruiz
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The income of psychiatrists: adaptation during difficult economic times
Authors: B Astrachan, S S Sharfstein
Journal: American Journal of Psychiatry (1986)

The earnings of psychiatrists are substantially lower than the earnings of physicians in procedurally oriented and surgical specialties of medicine. The authors offer evidence, however, that when it is compared to other cognitive medical specialties, such as pediatrics and internal medicine, psychiatry is the highest paid specialty on an hourly basis. In recent years, psychiatrists' income has improved, largely because of enhanced productivity and efficiency, diversification of treatments, work in multiple settings, the expansion of group practice, and subspecialization. The authors provide an optimistic perspective on the future of psychiatry as a medical specialty.
CSF copper concentrations in chronic schizophrenia
Authors: D Shore, S G Potkin, D R Weinberger, E F Torrey, R I Henkin, R P Agarwal, J C Gillin, R J Wyatt
Journal: American Journal of Psychiatry (1983)

The authors used a sensitive flameless atomic absorption spectrophotometric procedure to measure CSF copper concentrations in normal controls, former heroin addicts, and unmedicated and medicated chronic schizophrenic patients and found no significant differences in CSF copper levels between these groups. Schizophrenic women had significantly lower CSF copper levels than schizophrenic men, but no significant differences were found between control men and control women. There were no differences in CSF copper levels between patient subgroups with respect to diagnostic subtype (acute versus chronic, paranoid versus chronic undifferentiated), length of hospitalization, race, medication status, platelet monoamine oxidase values, or CAT scan abnormalities.
A biomagnetic method for measuring gastrointestinal contraction in diabetic rats
Authors: Madileine Francely Americo, Rozemeire Garcia Marques, César Tadeu Spadella, Yuri Karen Sinzato, Luciana Aparecida Corá, José Ricardo de Arruda Miranda
Journal: Gut (2010)

Universidade Estadual Paulista, Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu
Re: Nizar M. Tannir, Eric Jonasch, Laurence Albiges, et al. Everolimus Versus Sunitinib Prospective Evaluation in Metastatic Non–Clear Cell Renal Cell Carcinoma (ESPN):A Randomized Multicenter Phase 2 Trial. Eur Urol 2016;69:866–74
Authors: Zhenyu Yang, Lin Qi, Minfeng Chen
Journal: European Urology (2016)
FENESTRATION OPERATION FOR OTOSCLEROSIS
Authors: I S HALL
Journal: JAMA (1949)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of field practice to registration trials of sorafenib in advanced HCC for effectiveness and tolerability.
Authors: S. Vavassori, M. Iavarone, A. Sangiovanni, R. Romeo, M. Colombo
Journal: Journal of Clinical Oncology (2010)

e14637 Background: Sorafenib is the standard of care for patients with advanced hepatocellular carcinoma (HCC) and compensated liver disease. We aimed to evaluate safety and efficacy of the treatment in the field-practice. Methods: From July 2008 all patients treated with sorafenib were consecutively evaluated for response (amended RECIST criteria) and tolerability to sorafenib. Blood tests were performed monthly; while radiological response was evaluated every two months by CT scan. Treatment was interrupted for side effects (SE), clinical deterioration or progression of HCC according to amended RECIST criteria. Results: Fifty-five Child-Pugh A patients were enrolled (16% BCLC B with massive HCC or progression after chemoembolization, 84% BCLC C). Portal vein invasion was present in 22 (40%) and extra hepatic metastases in 20 (36%). Sorafenib was the first line treatment for 21 (38%) patients. The median treatment time was 3.2 months (range: 8-480 days; 46% still on-treatment). Overall, the 6-month-survival was 62%. In the 30 patients with early response evaluation, 12 (40%) showed partial response, 15 (50%) had stable disease and 3 (10%) showed disease progression. SE included: arterial hypertension 33% (median time to appearance 14 days, 3 grade 3/4), hand-foot syndrome 27% (1 grade 3 requiring dose reduction), diarrhoea 27% (2 grade 3, requiring dose reduction), fatigue 38% (median time to appearance 19 days, grade 3 in 5, requiring dose reduction in 5 and discontinuation in 6). Treatment was stopped: for disease progression in 10 (median treatment duration 142 days), fatigue in 6 (median treatment duration 48 days), liver function deterioration in 9 (median treatment duration 95 days), allergic reaction in 1, bleeding from oesophageal varices in 3 (median treatment duration 42 days). One patient was lost to follow-up. Nine-teen (35%) patients (84% BCLC C) died of tumor progression. Conclusions: Fatigue and arterial hypertension were more commonly reported compared to the SHARP study (22% and 5%). The first SE required dose reduction or treatment discontinuation whiereas the second one was manageable. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Bayer
Clinical Outcomes in Children with Hemophilia B Treated Long Term with rFIXFc: Interim Results of the B-YOND Extension Study
Authors: Roshni Kulkarni, Beatrice Nolan, Carolyn M. Bennett, Kathelijn Fischer, David J Perry, Christopher Barnes, Huixing Yuan, Alejandra Ramirez-Santiago, Glenn F Pierce, Baisong Mei
Journal: Blood (2015)
COMPLICATIONS OF RESPIRATORY FAILURE
Authors: F A KINGERY
Journal: JAMA (1965)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Definitions of mania: concordance and prediction of outcome
Authors: I F Brockington, V F Hillier, A F Francis, J E Helzer, S Wainwright
Journal: American Journal of Psychiatry (1983)

The authors compare several definitions of mania in three series of patients. All the definitions were successful in selecting patients with a favorable outcome, but there were large differences in the number of patients diagnosed, ranging from 17 to 55. The Research Diagnostic Criteria (RDC) distinction between mania and schizoaffective mania proved useful in that the schizoaffective patients continued to show schizophrenic and paranoid symptoms, had more manic episodes, and had a poorer social outcome. The DSM-III tripartite division into nonpsychotic mania and two subgroups of psychotic mania did not appear to have a clear advantage over the RDC dichotomy in the prediction of outcome.
Excerpta Medica
Authors: B. T. STERN
Journal: Annals of Internal Medicine (1974)

Comments1 May 1974Excerpta MedicaB. T. STERNB. T. STERNSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-5-672_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: It appears from Professor Beatty's paper on searching the medical literature (Ann Intern Med79: 917-924, 1973) that he and, I suspect, many others in the United States are rather unfamiliar with theExcerpta Medicasystem. For, although he mentioned the use of the abstract journals, he is apparently unaware that our system is really a computer data base from which 60% of the material published in the various abstract journals is drawn. Therefore there is a considerable amount of information that is not printed in the journals and that is also used by doctors when they... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: B. T. STERNAffiliations: Excerpta Medica Croydon CRO 5HA Surrey England PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDRUG-INFORMATION SYSTEMS FOR HOSPITAL PHARMACISTS 1 May 1974Volume 80, Issue 5Page: 672-672KeywordsComputers ePublished: 1 December 2008 Issue Published: 1 May 1974 PDF downloadLoading ...
Acceleration of Enzymatic Desamidation of Glutamine by Several Inorganic Anions
Authors: Charles E. Carter, Jesse P. Greenstein
Journal: JNCI Journal of the National Cancer Institute (1947)

Journal Article Acceleration of Enzymatic Desamidation of Glutamine by Several Inorganic Anions Get access Charles E. Carter, Charles E. Carter assistant surgeon Search for other works by this author on: Oxford Academic PubMed Google Scholar Jesse P. Greenstein Jesse P. Greenstein chief biochemist National Cancer Institute, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 7, Issue 6, June 1947, Pages 433–436, https://doi.org/10.1093/jnci/7.6.433 Published: 01 June 1947 Article history Received: 24 February 1947 Published: 01 June 1947