tbuckley/cabot-search huggingface dataset:
The effect of financial management on alcohol-related hospitalization
Authors: B Spittle
Journal: American Journal of Psychiatry (1991)

Treatment-unresponsive alcoholics in New Zealand who are unable to care for themselves tend to be hospitalized for lengthy periods of time. The author examined the effect of adding financial management to the therapeutic management of such patients. The null hypothesis was that this would have no effect on the duration of alcohol-related hospitalization.All 61 alcoholic patients registered with an alcohol outpatient clinic who received financial management over a period of 6 years were included in the study. Their alcohol-related disabilities were so severe that they had resulted or were likely to result in lengthy or frequent periods of hospitalization. The financial management involved putting each patient's income into a checking account for which a budget advisory officer was cosignatory for withdrawals. The advisor saw to it that patients' basic living requirements were being met and that expenditure on alcohol was not having a detrimental effect. Participation was voluntary for voluntary patients and involuntary for committed patients. The durations of each patient's alcohol-related hospitalizations were compared for two equal periods of time before and after financial management was instituted.The null hypothesis was not supported. The duration of alcohol-related hospitalizations after financial management was instituted was 86% less than it was before such management.For the patient who is struggling in the face of excessive drinking to cope with the tasks of daily living, including the provision of adequate shelter and nutrition, the benefits of adding financial management to other therapeutic strategies should be considered.
Tumor-specific cytotoxic T lymphocyte activity determines colorectal cancer patient prognosis
Authors: Christoph Reissfelder, Slava Stamova, Christina Gossmann, Marion Braun, Andreas Bonertz, Ute Walliczek, Mario Grimm, Nuh N. Rahbari, Moritz Koch, Maral Saadati, Axel Benner, Markus W. Büchler, Dirk Jäger, Niels Halama, Khashayarsha Khazaie, Jürgen Weitz, Philipp Beckhove
Journal: Journal of Clinical Investigation (2015)
Brief Communication: Effects of 7,12-Dimethylbenz[a]anthracene on Rat Mammary Epithelial Cell Macromolecules: A Time Study2
Authors: Anne G. Jabara, Laura C. Minasian, Jane P. Matthews
Journal: JNCI Journal of the National Cancer Institute (1975)

The effects of 7,12-dimethylbenz[a]anthracene (DMBA) on levels of four mammary epithelial cell macromolecules were investigated at various times between 1 and 14 days after Sprague-Dawley virgin female rats were fed the carcinogen. Whereas the level of nuclear protein remained relatively constant throughout this period, comparison with normal controls revealed that significant reductions in nuclear RNA and cytosol protein levels occurred in cells from DMBA-treated animals 24 hours after carcinogen treatment; levels were lowest within the first 3 days. Cytosol protein and nuclear RNA values then increased progressively, reaching normal levels between 4 and 6 days; they were elevated 122% (+/-6 SD) and 41% (+/-5), respectively, above controls by the 14th day. DNA levels remained within normal limits up to the 4th day, after which they gradually increased to 36% (+/-5) above normal by the 14th day. All four macromolecules in neoplastic epithelial cells derived from three mammary adenocarcinomas approximately 135 days after DMBA was fed to rats showed increases similar to, though more pronounced than, those seen in mammary epithelial cells 14 days after carcinogen administration, which suggested that early changes in these macromolecules, especially in RNA and cytosol protein, may be related to DMBA mammary carcinogenesis. The data further suggested that malignant transformation of the epithelial cells may occur within the first 4-6 days, after which there appears to be a loss of normal synthetic control of nuclear DNA, RNA, and cytosol protein.
Control of Mouse Pox (Infectious Ectromelia) by Immunization with Vaccinia Virus&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: J. J. Trentin, M. A. Ferrigno
Journal: JNCI Journal of the National Cancer Institute (1957)

Control of Mouse Pox (Infectious Ectromelia) by Immunization with Vaccinia Virus23 J. J. Trentin, J. J. Trentin Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar M. A. Ferrigno M. A. Ferrigno Department of Anatomy, Yale University School of Medicine, New Haven, Connecticut Search for other works by this author on: Oxford Academic PubMed Google Scholar 4Present address: Department of Anatomy, Baylor University College of Medicine and University of Texas Dental Branch, Houston, Texas. Author Notes JNCI: Journal of the National Cancer Institute, Volume 18, Issue 5, May 1957, Pages 757–767, https://doi.org/10.1093/jnci/18.5.757 Published: 01 May 1957 Article history Received: 18 February 1957 Published: 01 May 1957
PTU-329 Do different referral pathways for upper gi cancer alter outcomes?
Authors: S Barker, J Jinnah, E Chaudary
Journal: Gut (2015)

<h3>Introduction</h3> The TWR referral pathway was first introduced in 2000 in an attempt to diagnose upper GI cancer at an earlier more treatable stage, to improve outcomes and mortality rates in the UK. However, a number of cases are still diagnosed through other referral routes including emergency admissions and routine referral. The aim of this study was to determine the route of referral for patients diagnosed with Oesophago-Gastric (OG) cancer and the effects, if any, on outcomes. <h3>Method</h3> All patients newly diagnosed with an OG cancer between March 2013 to Sept 2014 at St George’s Hospital were identified using the histology database. Patient demographics were obtained. The original source of referral of these patients was identified, including TWR referral, emergency admission or referral via another consultant. Presenting features were documented. The tumour site was recorded from the gastroscopy reports and the histology documented. The staging and outcome with treatment intent, including curative, palliative or best supportive care was noted and reasons for this. The outcome of patients was compared to their mode of referral. <h3>Results</h3> A total of 86 patients were diagnosed with OG cancer in the 18 month period from March 2013-Sept 2014. 57 (66%) were male. 13% were &lt;55 years old. 43% had been referred through the upper GI TWR pathway, 33% were diagnosed after having been admitted as an emergency and 21% were referred from other consultants. Only one patient was diagnosed while being on Barrett’s surveillance programme. Those that were diagnosed after an emergency admission tended to be older with 61% &gt;75 years compared with 46% of those on the TWR pathway. Of those that were referred through the TWR pathway, 52% had oesophageal cancer, 32% gastric cancer and 16% cancer at the GOJ. While 57% of patients diagnosed at an emergency admission had gastric cancer with 25% having oesophageal cancer. Of those that had been diagnosed after an emergency admission, only one had curative treatment. 39% received palliative treatment (55% having palliative chemotherapy, 27% having a stent insertion and 18% having radiotherapy). While 54% had no active treatment given. This compares to those diagnosed through the TWR pathway where 34% were treated with curative intent (22% with surgery and chemotherapy and 13% with radical chemo-radiation). 51% received palliative treatment with chemotherapy (68%), radiotherapy (26%), while only 11% had no active treatment. <h3>Conclusion</h3> Many cancers are diagnosed outside of the TWR pathway though emergency presentation and referral from other consultants. The outcomes of patients referred through the TWR pathway are significantly better and there needs to be ongoing education and appropriate referral onto this pathway. <h3>Disclosure of interest</h3> None Declared.
Cardiovascular Mortality in Patients With Type 2 Diabetes and Recent Acute Coronary Syndromes From the EXAMINE Trial
Authors: William B. White, Stuart Kupfer, Faiez Zannad, Cyrus R. Mehta, Craig A. Wilson, Lanyu Lei, George L. Bakris, Steven E. Nissen, William C. Cushman, Simon R. Heller, Richard M. Bergenstal, Penny R. Fleck, Christopher P. Cannon
Journal: Diabetes Care (2016)

We evaluated the risk of cardiovascular (CV) death in all Examination of Cardiovascular Outcomes with Alogliptin versus Standard of Care (EXAMINE) study participants and in those who experienced an on-study, major nonfatal CV event.The study randomly assigned 5,380 patients with type 2 diabetes to alogliptin or placebo within 15 to 90 days of an acute coronary syndrome (ACS). Deaths and nonfatal CV events (myocardial infarction [MI], stroke, hospitalized heart failure [HHF], and hospitalization for unstable angina [UA]) were adjudicated. Patients were monitored until censoring or death, regardless of a prior postrandomized nonfatal CV event. Time-updated multivariable Cox models were used to estimate the risk of death in the absence of or after each nonfatal event.Rates of CV death were 4.1% for alogliptin and 4.9% for placebo (hazard ratio [HR] 0.85; 95% CI 0.66, 1.10). A total of 736 patients (13.7%) experienced a first nonfatal CV event (5.9% MI, 1.1% stroke, 3.0% HHF, and 3.8% UA). Compared with patients not experiencing a nonfatal event, the adjusted HR (95% CI) for death was 3.12 after MI (2.13, 4.58; P < 0.0001) 4.96 after HHF (3.29, 7.47; P < 0.0001), 3.08 after stroke (1.29, 7.37; P = 0.011), and 1.66 after UA (0.81, 3.37; P = 0.164). Mortality rates after a nonfatal event were comparable for alogliptin and placebo.In patients with type 2 diabetes and a recent ACS, the risk of CV death was higher after a postrandomization, nonfatal CV event, particularly heart failure, compared with those who did not experience a CV event. The risk of CV death was similar between alogliptin and placebo.
Human trichinellosis due to Trichinella britovi in southern France after consumption of frozen wild boar meat
Authors: M Gari-Toussaint, N Tieulié, J  L Baldin, J Dupouy-Camet, P Delaunay, J G Fuzibet, Y Le Fichoux, E Pozio, P Marty
Journal: Eurosurveillance (2005)

Six patients were infected with Trichinella britovi in southern France following consumption of frozen wild boar meat, which had been frozen at -35°C for 7 days. Microscopic examination of a sample of frozen wild boar muscle revealed the presence of rare encapsulated Trichinella larvae, identified as T. britovi. People eating wild boar must follow individual prophylactic rules such as efficient cooking of meat (at least 65°C at the core for 1 minute) as recommended by the International Commission on Trichinellosis, or freezing exceeding four weeks at -20°C.
The Role of Graft and Host Vessels in the Vascularization of Grafts of Normal and Neoplastic Tissue
Authors: Ruth M. Merwin, Glenn H. Algire
Journal: JNCI Journal of the National Cancer Institute (1956)

The Role of Graft and Host Vessels in the Vascularization of Grafts of Normal and Neoplastic Tissue Get access Ruth M. Merwin, Ruth M. Merwin National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Glenn H. Algire Glenn H. Algire National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 1, July 1956, Pages 23–33, https://doi.org/10.1093/jnci/17.1.23 Published: 01 July 1956 Article history Received: 02 February 1956 Published: 01 July 1956
PTH-286 Molecular staging of colorectal cancer – proteomic approach
Authors: M Uppara, M Moorghen
Journal: Gut (2015)

<h3>Introduction</h3> Colorectal carcinogenesis is a multistep process which results from alterations in oncogenes and tumour suppressor genes combined with epigenetic events. Our aim is to refine further the clinical and pathological staging of colorectal cancer by identifying biomarkers of late tumour progression. As the tumour evolves it acquires a number of biological characteristics such as continuing proliferation, avoiding apoptosis etc., collectively referred to as the hallmarks of cancer. In this study we conducted a literature search in order to identify the set of proteins associated with these hallmarks in relation to colorectal cancer. From this long list of biomarkers we proceeded to select those which are associated with hallmarks which are expected to be relevant as late events in the multistep process of colorectal carcinogenesis using a computerised protein-protein network analysis approach. <h3>Method</h3> We conducted a search in database Embase and Medline until October 2013 using search terms: colorectal cancer (CRC), colorectal neoplasia, metabolic phenotyping and mass spectrometry. Two hundred and thirty seven records were screened from the search for eligibility. Fifty-seven articles were found be studies relevant for gene expression profiles of CRC. Eight articles met inclusion criteria hence included for quantitative synthesis. All the biomarkers identified in this review were divided according to six-predefined hallmarks of cancer progression. We considered the hallmarks of angiogenesis, invasion and metastasis to represent late events and we identified a total of more than 30 associated protein biomarkers. We used the graph web network software to analyse protein – protein interaction among the protein biomarkers representing late hallmarks. <h3>Results</h3> 13 Hub protein molecules, which scored more than 90% function in the networks, are mostly ribosomal proteins they are: RPS 27 A, RPS 15 A, RPS 11, RPS29, RPS 4X, RPS 13, RPS 18, RPS 19, RPS 27, RPL 3L, RPL4, RPS21, UBA52. 6 Hub protein molecules, which scored more than 95% function in the networks, are: RPS 27A, UBA52, RPS 19, RPS 27, RPL 4, RPS 21. <h3>Conclusion</h3> We hypothesise that proteomic analysis of colorectal cancer samples targeting these proteins will provide additional prognostic information and could possibly form the basis of personalised therapy in the future. <h3>Disclosure of interest</h3> None Declared.
SP0052 Incidence, Significance and Clinical Approach to the Raynaud's Phenomenon
Authors: A.L. Herrick
Journal: Annals of the Rheumatic Diseases (2015)

Raynaud9s phenomenon (RP) is common, affecting in the order of 5% of the population. In most cases it is primary (idiopathic), when attacks are completely reversible and do not progress to tissue injury. However, RP can also be secondary to a number of different diseases/conditions. The significance of RP to the rheumatologist is that it can be the presenting feature of connective tissue disease, in particular of systemic sclerosis (SSc)-spectrum disorders, and therefore presents a window of opportunity for early diagnosis. Abnormal nailfold capillaroscopy and SSc-specific autoantibodies are independent predictors of progression to SSc. Upon completion of the session, participants should be able to: Discuss the approach to the patient with RP, including separating primary RP from SSc-related RP. Describe the rationale for very early diagnosis of SSc. <h3>Disclosure of Interest</h3> None declared
PTU-192 Management of anal intraepithelial neoplasia (AIN): a multicentre audit
Authors: DJ Lin, M Ali, D O’Connell, C Harmston
Journal: Gut (2015)

Introduction  Anal intraepithelial neoplasia (AIN) although rare is a precursor to anal squamous cell cancer (SCC). There is little evidence on the effectiveness of follow-up protocols. This audit aimed to assess the compliance with follow-up guidelines from The Association of Coloproctology of Great Britain and Ireland (ACPGBI).  Method  A retrospective multicentre audit was performed, all patients with histologically confirmed AIN from 1 Jan 2008 were identified from the cancer network pathology database with a centralised anal MDT. Assessment, follow-up, and outcomes were obtained from the hospitals clinical results reporting system and compared to the ACPGBI published guidelines on AIN.  Results  There were a total of 24 patients, 37.5% male (n = 9), with AIN. Mean age 58 (range 20–94). Mean follow-up time 24 months (range 2–65). 16.6% had AIN1 (n = 4), 16.6% had AIN2 (n = 4), 66.6% had AIN3 (n = 16). Of the patients diagnosed with AIN3, 75% (n = 14) were discussed at anal MDT, 100% (n = 16) had guideline compliant follow-up. Of the 8 patients with AIN1 or AIN2, 62.5% (n = 5) had at least 6 monthly follow-up, 43.7% (n = 7) of patients with AIN3 had a re-biopsy of the site of lesion. 1 (6.5%) patient with AIN3 progressed within 1 year to squamous cell carcinoma. 75% of female patients with AIN were managed with a gynaecologist.  Conclusion  This study showed that, once diagnosed with AIN, there is good compliance with guideline focused follow-up, and the majority of patients are discussed in a centralised anal MDT. Progression to anal cancer was in keeping with that seen in other studies.  Disclosure of interest  None Declared.
Sodium-Lithium Countertransport in Erythrocytes of Pregnant Women
Authors: J K Aronson, M P Moore, C W Redman, C Harper
Journal: New England Journal of Medicine (1982)

To the Editor: The report by Worley et al. (August 12 issue)1describing increased sodium–lithium countertransport in the erythrocytes of pregnant women parallels a recent study of ours. We studied three groups of women in the third trimester of pregnancy and six weeks after delivery: 18 women with pre-eclampsia, 14 women with essential hypertension, and women with uncomplicated pregnancies who were matched for gestation and parity with the women in the other two groups. We measured three aspects of erythrocyte cation transport: the ability of erythrocyte membranes to bind [3H]digoxin specifically (as a measure of the numbers of. © 1982, Massachusetts Medical Society. All rights reserved.
Fluphenazine decanoate: a clinical problem?
Authors: L B Inderbitzin, R R Lewine, B A Gloersen, P B Rosen, S C McDonald, B P Vidanagama
Journal: American Journal of Psychiatry (1989)

The authors compared the medical records of 20 randomly selected schizophrenic patients who were receiving fluphenazine decanoate with the records of 20 other randomly selected schizophrenic patients who were receiving oral medications only. The fluphenazine decanoate group had a significantly higher mean chlorpromazine equivalent dose (2010 +/- 836) than the oral medication group (373 +/- 384). The two groups did not, however, differ on any of the other variables studied. The findings, in addition to reports in the literature, suggest that the use of fluphenazine decanoate may come at the inadvertent cost of a significantly higher dose of antipsychotic medications in a subgroup of patients.
Case 40-1983
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, John G. Krikorian, E. Tessa Hedley-Whyte
Journal: New England Journal of Medicine (1983)

Presentation of CaseA 40-year-old woman was admitted to the hospital because of fever and a right preauricular mass.She was well until six years earlier, when pain developed in the left ear. Several months later headaches appeared, and she noticed occasional deviation to the left on walking. Five years before admission a seizure occurred, and neurologic evaluation revealed bilateral papilledema, without focal abnormalities. A computed tomographic (CT) scan of the brain showed a mass in the right parietal lobe. A right superior parietal lobectomy was performed, and microscopical examination of the surgical specimen disclosed a Grade III glioma, with . . .
Chromosomal Studies on Primary Methylcholanthrene-Induced Sarcomas in the Mouse&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: K. E. Hellström
Journal: JNCI Journal of the National Cancer Institute (1959)

Cytological studies of chromosomes have been made on 14 primary fibrosarcomas induced by intramuscular injection of methylcholanthrene. All tumors showed a considerable variability in chromosome number. Ten tumors were characterized by stem lines, which were changed chromosomally and were individually different for each neoplasm. These results agree with existing data on transplanted methylcholanthrene-induced sarcomas. Four tumors contained cells with the normal diploid number of 40 chromosomes as their dominating stem line and did not show any detectable structural modifications. The difference between tumors might be due to the fact that they have reached various stages of progression. It also appears that great structural or numerical chromosome changes are not necessary for the development of all tumors.
AB1190 The Characteristics of Autoimmune Associated Lung Disease in Korean Patients
Authors: Y.H. Seo, S.J. Choi, Y.H. Lee, J.D. Ji, G.G. Song
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Connective tissue diseases (CTD) are known to have variable clinical symptoms and progression at multiple organ. Above all, the lung involvement of CTD shows the worst clinical course. The causes of CTD have not been well understood, and in most cases, the diagnosis of CTD requires diverse clinical, pathological, and imaging tests. So, the role of anti-nuclear antibodies (ANAs) in the diagnosis of CTD has been more important, especially in the cases of interstitial lung diseases (ILD), the cause of which is not obvious. In a study of ILD, which was conducted in Korea, ANA was positive in 66.1% of ILD patients. These findings suggest that ANA could be related with ILD or other lung diseases. <h3>Objectives</h3> We conducted a retrospective study, in which the object was to assess the percentage of lung disease in ANA positive patients. <h3>Methods</h3> We retrospectively reviewed 558 patients with ANA positive from a single tertiary center in Korea between 2011 and 2013. <h3>Results</h3> Among 588 ANA positive patients, 145 patients were associated with lung disease (24.7%). The lung disease of 35 patients were diagnosed with ILD (24.1%), 8 patients were lung cancer (5.5%), 6 patients were pneumonia (4.1%), and 5 patients were pulmonary tuberculosis (3.4%). <h3>Conclusions</h3> In our study, a substantial proportion of patients with ANA positive were found to have variable lung diseases. ILD was most common, and was diagnosed in 24.1% of ANA positive patients, but we found that lung cancer, pneumonia, and pulmonary tuberculosis could be diagnosed in ANA positive patients. Our findings suggest that the ANA could be positive in variable lung disease, and more specific, but not yet detected antibodies might be related with lung diseases. <h3>Disclosure of Interest</h3> None declared