tbuckley/cabot-search huggingface dataset:
Influence of Thyrotrophin on Growth of Transplantable Thyroid-Gland Tumors of Mice
Authors: Harold P. Morris, Billie P. Wagner, Harry J. Lipner
Journal: JNCI Journal of the National Cancer Institute (1959)

The administration of diets high or low in iodide did not affect the growth rate of independent, mouse, transplantable thyroid-gland tumors of sublines 3C and 4JW. The inclusion of propylthiouracil (PTU) in the diet increased the growth rate at the 6th week and resulted in an alteration in the morphology of the tumors of subline 3C. No significant change could be detected in the histologic features or tumor growth of the 4JW and 6 tumor sublines in the PTU-treated animals. Exogenous thyrotrophin administered for 33 days to mice bearing lines 3C or 4JW resulted in some increased growth of line 3C tumors and some slowing of growth of line 4JW tumors. Similar effects on tumor growth of these lines were obtained in mice subtotally thyroidectomized with radioiodide. In no case was the activity of the iodide pump significantly altered. The thyroid glands of tumor-bearing mice fed PTU did not enlarge as rapidly beyond 3 weeks as did the glands of non-tumor-bearing mice ingesting the goitrogen.
Detection of Coronary Stenosis at Rest Using BOLD-CMR
Authors: J. Ranjit Arnold, Michael Jerosch-Herold, Theodoros D. Karamitsos, Jane M. Francis, Paul Bhamra-Ariza, Rizwan Sarwar, Robin Choudhury, Joseph B. Selvanayagam, Stefan Neubauer
Journal: JACC. Cardiovascular imaging (2016)
Estimating the risk of second primary tumors following cancer treatment.
Authors: J R Harris, C N Coleman
Journal: Journal of Clinical Oncology (1989)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1989.7.1.5 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2909668 Estimating the risk of second primary tumors following cancer treatment. J R HarrisxJ R HarrisSearch for articles by this author , C N ColemanxC N ColemanSearch for articles by this author https://doi.org/10.1200/JCO.1989.7.1.5 PDF "Estimating the risk of second primary tumors following cancer treatment.." Journal of Clinical Oncology, 7(1), pp. 5–6© 1989 by American Society of Clinical Oncology
Metal-linked Immunosorbent Assay (MeLISA): the Enzyme-Free Alternative to ELISA for Biomarker Detection in Serum
Authors: Ru-Jia Yu, Wei Ma, Xiao-Yuan Liu, Hong-Ying Jin, Huan-Xing Han, Hong-Yang Wang, He Tian, Yi-Tao Long
Journal: Theranostics (2016)

Determination of disease biomarkers in clinical samples is of crucial significance for disease monitoring and public health.The dominating format is enzyme-linked immunosorbent assay (ELISA), which subtly exploits both the antigen-antibody reaction and biocatalytic property of enzymes.Although enzymes play an important role in this platform, they generally suffer from inferior stability and less tolerant of temperature, pH condition compared with general chemical product.Here, we demonstrate a metal-linked immunosorbent assay (MeLISA) based on a robust signal amplification mechanism that faithfully replaces the essential element of the enzyme.As an enzyme-free alternative to ELISA, this methodology works by the detection of α-fetoprotein (AFP), prostatic specific antigen (PSA) and C-reactive protein (CRP) at concentrations of 0.1 ng mL -1 , 0.1 ng mL -1 and 1 ng mL -1 respectively.It exhibits approximately two magnitudes higher sensitivity and is 4 times faster for chromogenic reaction than ELISA.The detection of AFP and PSA was further confirmed by over a hundred serum samples from hepatocellular carcinoma (HCC) and prostate cancer patients respectively.
Reply—Letter to the Editor: What to Do, and What Not to Do, When Diagnosing and Treating Breakthrough Cancer Pain (BTcP): Expert Opinion
Authors: R. Vellucci, G. Fanelli, P. A. Cortesi, R. Pannuti, C. Peruselli, P. Romualdi
Journal: Drugs (2016)

Consistent with the motto ''Actions speak louder than words'', we have gathered a group of opinion leaders in palliative care and pain treatment who, for several years, have been committed to treat breakthrough cancer pain (BTcP).Our experience, gained by close contact with cancer pain sufferers, has allowed us to explore the literature on BTcP and to transfer it into clinical practice.We are convinced that the situation in Italy [3,4], in Europe [5] and in other countries [6], is far from encouraging.In Italy, the phenomenon of under-treatment of cancer patients [7] and BTcP [3,4,8] is still an important problem.It must be made clear that rapid-onset opioids (ROOs) do not seem to be used very often in clinical practice [5,8], as can be indirectly deduced from the Italian sales data.
The use of methylphenidate and imipramine in Gilles de la Tourette's disease in children
Authors: I Fras, J Karlavage
Journal: American Journal of Psychiatry (1977)

The authors treated two children with Gilles de la Tourette's disease and one child with a probable combination of Gilles de la Tourette's disease and minimal brain dysfunction with methylphenidate, which resulted in exacerbation of symptoms. One child was briefly treated with imipramine, with similar results. The authors suggest that these pharmacologic agents should be used cautiously in treating patients with possible movement disorders (tics) and conclude that their findings lend support to the catecholamine hypothesis of the etiology of Gilles de la Tourette's disease.
Résistance aux antibiotiques d'isolats de Salmonella enterica issus de cas de salmonellose humaine en Europe en 2000 : résultats d'une surveillance multicentrique internationale
Authors: E J Threlfall, I. S.T. Fisher, C Berghold, P Gerner-Smidt, H Tschäpe, M Cormican, L Luzzi, F Schneider, W J B Wannet, J Machado, G Edwards
Journal: Eurosurveillance (2003)

En 2000, le reseau Enter-net a collecte les resultats d'antibiogrammes pour des isolats issus de plus de 27 000 cas de salmonellose humaine, repartis dans dix pays europeens. Pres de 40% etaient resistants a un antibiotique au moins, 18% etaient multiresistants. La resistance a l'ampicilline, a la streptomycine, aux sulphonamides et aux tetracyclines etait frequente, avec plus de 20 % de resistance a au moins un de ces antibiotiques. La resistance clinique a la ciprofloxacine etait rare, avec seulement 0,5% de resistance (CMI g1,0 mg/l). La resistance a l'acide nalidixique couplee a une sensibilite reduite de la ciprofloxacine (CMI 0,25-1,0 mg/l) etait plus frequente, presente chez 14% des isolats. La resistance aux cephalosporines de troisieme generation etait rare, avec un taux de resistance de 0,6% seulement a la cefotaxime. Dans tous les pays, le taux de multiresistance etait le plus eleve chez Salmonella enterica Typhimurium, avec 51% d'isolats multiresistants au total. En Angleterre et au Pays de Galles, la multiresistance etait egalement prevalente chez S. Virchow et S. Hadar, alors que dans d'autres pays elle etait courante pour les serotypes tels que S. Blockley.
ST Segment Elevation ECG Changes During Pharmacologic Stress With Regadenoson
Authors: Salima Qamruddin, Henry W. Huang, Anil Mehra, Shahram Bonyadlou, Andrew J. Yoon
Journal: Clinical Nuclear Medicine (2015)

Regadenoson is a pharmacologic stress agent that has been widely adopted as an alternative over other pharmacologic vasodilator agents due to its ease of use, patient tolerance, and safety profile. We report the case of dynamic ST-segment elevation electrocardiogram changes after regadenoson injection during an inpatient single-photon emission computed tomography myocardial perfusion stress test, with subsequent coronary angiography revealing the presence of hemodynamically significant coronary artery disease. Our findings confirm that transient regadenoson-induced ST-segment elevations are a marker for hemodynamically significant disease even in the setting of low-risk SPECT perfusion images.
Morphological and molecular features of astroblastoma, including<i>BRAFV600E</i>mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults
Authors: Norman L. Lehman, Eyas M. Hattab, Bret C. Mobley, Aisulu Usubalieva, Matthew J. Schniederjan, Roger E. McLendon, Werner Paulus, Elisabeth J. Rushing, Maria-Magdalena Georgescu, Marta Couce, Mohanpal S. Dulai, Mark L. Cohen, Christopher R. Pierson, Jack M. Raisanen, Sarah E. Martin, Trang D. Lehman, Eric S. Lipp, Jose M. Bonnin, Mousa A. Al-Abbadi, Kara Kenworthy, Kevin Zhao, Nehad Mohamed, Guojuan Zhang, Weiqiang Zhao
Journal: Neuro-Oncology (2016)

Abstract Background. Astroblastomas (ABs) are rare glial tumors showing overlapping features with astrocytomas, ependymomas, and sometimes other glial neoplasms, and may be challenging to diagnose. Methods. We examined clinical, histopathological, and molecular features in 28 archival formalin-fixed, paraffin-embedded AB cases and performed survival analyses using Cox proportional hazards and Kaplan–Meier methods. Results. Unlike ependymomas and angiocentric gliomas, ABs demonstrate abundant distinctive astroblastic pseudorosettes and are usually Olig2 immunopositive. They also frequently exhibit rhabdoid cells, multinucleated cells, and eosinophilic granular material. They retain immunoreactivity to alpha thalassemia/mental retardation syndrome X-linked, are immunonegative to isocitrate dehydrogenase-1 R132H mutation, and only occasionally show MGMT promoter hypermethylation differentiating them from many diffuse gliomas. Like pleomorphic xanthoastrocytoma, ganglioglioma, supratentorial pilocytic astrocytoma, and other predominantly cortical-based glial tumors, ABs often harbor the BRAFV600E mutation, present in 38% of cases tested (n = 21), further distinguishing those tumors from ependymomas and angiocentric gliomas. Factors correlating with longer patient survival included age less than 30 years, female gender, absent BRAFV600E, and mitotic index less than 5 mitoses/10 high-power fields; however, only the latter was significant by Cox and Kaplan–Meier analyses (n = 24; P = .024 and .012, respectively). This mitotic cutoff is therefore currently the best criterion to stratify tumors into low-grade ABs and higher-grade anaplastic ABs. Conclusions. In addition to their own characteristic histological features, ABs share some molecular and histological findings with other, possibly ontologically related, cortical-based gliomas of mostly children and young adults. Importantly, the presence of BRAFV600E mutations in a subset of ABs suggests potential clinical utility of targeted anti-BRAF therapy.
Wrinkled‐Surface Mediated Reverse Transfection Platform for Highly Efficient, Addressable Gene Delivery
Authors: Hyunwoo Joo, Jisoo Shin, Seung‐Woo Cho, Pilnam Kim
Journal: Advanced Healthcare Materials (2016)

A novel reverse transfection platform, which embraces a wrinkled-surface, is developed for highly efficient long-term gene delivery. Since reverse transfection utilizes the contact between cell and substrate, the increase in the contact area between substrate and cells significantly increases the gene delivery rate. Furthermore, by adopting microwell structures, multiplex, addressable delivery of exogenous materials is successfully demonstrated. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Anorectal lymphogranuloma venereum: the first two confirmed cases in Portugal
Authors: R Castro, T Baptista, A Vale, H Nunes, E Prieto, K Mansinho, F da Luz Martins Pereira
Journal: Eurosurveillance (2008)

We describe two cases of lymphogranuloma venereum (LGV) in men who have sex with men in Portugal in 2008. These first two confirmed cases of LGV L2b proctitis in Portugal highlight the need for an enhanced surveillance programme in Portugal.
ESB : le contexte réglementaire européen
Authors: Thierry Chalus, Isabelle Peutz
Journal: Eurosurveillance (2000)

La crise de l’Encephalopathie Spongiforme Bovine (ESB) a provoque une reevaluation fondamentale de l’approche de la Communaute Europeenne sur les questions de securite alimentaire. Entre le 28 juillet 1989, date de restriction de l’importation de certains bovins provenant du Royaume-Uni et le 29 juin 2000, date d’interdiction d’utilisation des tissus presentant un risque particulier en matiere d’ESB, appeles Materiels a Risques Specifies (MRS) dans toute l’Union Europeenne, toutes les mesures communautaires se sont appuyees sur les ‘clauses de sauvegarde’ definies dans les diverses directives veterinaires. A terme et conformement au Traite d’Amsterdam, l’ensemble des mesures prises devrait etre remplace par une legislation primaire faisant intervenir le Parlement Europeen, le Conseil et la Commission.
Forensic Stomatology
Authors: Reidar F. Sognnaes
Journal: New England Journal of Medicine (1977)

Developmental CharacteristicsThere are a number of developmental dental characteristics that may give a clue to a person's identity. These identifying features are in part due to various pathologic systemic influences, especially during the early period of tooth development. But more important for general purposes of identification is the information that the dentition at various stages of normal development can provide regarding age at the time of death.Metabolic Dental MarkersDuring the period of formation and calcification the dentition represents a sensitive kymograph of metabolic disturbances. Even the event of birth is registered by the accentuated incremental lines separating . . .
The Natural History of the Neutrophil Elastase and Coagulation Factor Response to E.coli in a Baboon Model of E.coli/Sepsis Suggests That Elevated Neutrophil Elastase Activity Is Sustained Regardless of Outcome in Clinical Sepsis.
Authors: John A. Samis, Kenneth A. Stewart, Fletcher B. Taylor, Daniel J. Fournier, Michael E. Nesheim
Journal: Blood (2006)
The prevalence <i>RAS </i>and <i>BRAF </i>mutations among patients in the Middle East and Northern Africa with metastatic colorectal cancer.
Authors: Tamer Garawin, Kimberly Lowe, George Kafatos, Samuel Murray
Journal: Journal of Clinical Oncology (2016)

598 Background: Anti-EGFR therapies are recommended for metastatic colorectal cancer (mCRC) patients with confirmed wild-type RAS (exons 2, 3, 4 of KRAS and NRAS) status. There is limited published information on the prevalence of RAS mutations using real world data. The objective of this study was estimate the prevalence of RAS and BRAF mutations among patients with mCRC in the Middle East and Northern Africa (MENA) in an effort to inform the rationale for biomarker testing and treatment choice. Methods: The study included 1,669 patients from August 2013 to July 2015 with mCRC from Algeria, Bahrain, Egypt, Jordan, Kuwait, Lebanon, Libya, Morocco, Oman, Qatar, Saudi Arabia, and the United Arab Emeritus. Information on RAS mutation status was obtained from one pathology lab using High Resolution Melting Analysis. Extended RAS analysis was conducted in a subset of patients, including: overall RAS (exon 2, 3, 4 of KRAS and NRAS; n = 750), KRAS exon 2 (n = 750), KRAS exon 3 and 4 (n = 507), NRAS exon 2, 3, and 4 (n = 507), and BRAF exon 15 (n = 78). The proportion of patients with each mutation was summarized. Results: The overall RAS mutation in the full sample was 35.3% (n = 589/1669). The observed mutation for KRAS exon 2 in a subset of patients with extended RAS analysis (n = 750) was 32.4% (243/750). Out of the subjects with wild-type exon 2 (n = 507), the observed mutations rates were as follows: KRAS exon 4 (20/507 = 3.9%), KRAS exon 3 (13/507 = 2.6%), NRAS exon 2 (7/507 = 1.4%), NRAS exon 3 (6/507 = 1.2%), and NRAS exon 4 (0%). The prevalence of BRAF exon 15 was 3.8% (3/78). The most robust data on specific RAS mutations was obtained from Algeria, Egypt, and Saudi Arabia. The prevalence of KRAS exon 2 mutations in these countries was as follows: Algeria (n = 33/86 = 38.4%), Egypt (n = 83/303 = 27.4%), Saudi Arabia (n = 85/245 = 34.7%). Conclusions: To our knowledge, this is the first study to evaluate the prevalence of RAS and BRAF mutations in the Middle East using real world data. The results of this descriptive study illustrate that there is variation in the prevalence of RAS and BRAF mutations in MENA.
The Prevalence of Extramedullary AML Detected By 18-FDG/PET-CT: Results from the Prospective PET-AML Trial
Authors: Friedrich Stölzel, Tors Lüer, Stefani B Parmentier, Tobias Paulus, Friederike Kuithan, Michael Kramer, Nael Alakel, Katja Sockel, Franziska Taube, Jörg Kotzerke, Christoph Röllig, Martin Bornhäuser, Gerhard Ehninger, Klaus Zoephel, Markus Schaich
Journal: Blood (2014)
Senior medical students' perceptions of the psychiatric clerkship
Authors: P G Bashook, S H Weissman
Journal: American Journal of Psychiatry (1982)

The psychiatric clerkship serves the unique role of being the basic psychiatric experience for all physicians. The authors surveyed 680 senior medical students (representing a mean of 32.4% of the students at 15 American medical schools) to obtain information on their experiences and perceptions of this clerkship. These students' perceptions raise potentially serious questions as to the effectiveness of the clerkship in meeting educational needs. The medical students perceived the clerkship as essential for their future careers but considered it easy compared with other clerkships. This perception of easiness has implications both for recruiting psychiatrists and for how practicing nonpsychiatric physicians view psychiatry.
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Authors: Hong Jiang, Samarth Hegde, Brett L Knolhoff, Yu Zhu, John M Herndon, Melissa A Meyer, Timothy M Nywening, William G Hawkins, Irina M Shapiro, David T Weaver, Jonathan A Pachter, Andrea Wang-Gillam, David G DeNardo
Journal: Nature Medicine (2016)
Abstract 3938: MafB and ETS2 potentiate Notch signaling in T-ALL
Authors: Kostandin Pajcini, Lanwei Xu, Curtis Lee, Sara Cherry, Warren Pear
Journal: Cancer Research (2015)

Abstract Despite the high frequency of activating Notch mutations in human T-cell acute lymphoblastic leukemia (T-ALL), these naturally occurring Notch1 mutant alleles fail to efficiently drive leukemia onset, indicating a requirement for collaborating events that potentiate the Notch oncogenic program. We performed an in vitro gain-of-function screen to identify gene products that enhanced the signaling strength of naturally occurring Notch mutants. Both MafB and ETS2 emerged as candidates that individually potentiated Notch signaling, and when co-expressed, they dramatically enhanced signaling strength comparable to the levels induced by MAML1, a core component of the Notch transcriptional complex. Knockdown of MafB in mouse T-ALL cell lines suppressed the expression of common Notch target genes, including cMyc and Hes1, and sustained knockdown of MafB expression impaired T-ALL cell growth in cell competition assays. Notably, MafB is sufficient to enhance the oncogenic potential of naturally occurring Notch mutants in vivo, by significantly accelerating T-ALL onset. Moreover, this enhanced Notch pathway activation required MafB-ETS2 interaction, and facilitated the recruitment of PCAF and p300. Although all primary human T-ALL samples that express MafB display an elevated Notch pathway signature, the T-ALL samples positive for high levels of MafB expression, exhibit low levels of Notch1 expression, further suggesting a role for MafB as an enhancer. These data present a novel mechanism for the enhancement of the oncogenic potential of weak Notch mutants in leukemia and introduce MafB as a potential therapeutic target in T-ALL. Note: This abstract was not presented at the meeting. Citation Format: Kostandin Pajcini, Lanwei Xu, Curtis Lee, Sara Cherry, Warren Pear. MafB and ETS2 potentiate Notch signaling in T-ALL. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3938. doi:10.1158/1538-7445.AM2015-3938
Adolescent Volunteering
Authors: Megan A. Moreno, Fred Furtner, Frederick P. Rivara
Journal: JAMA Pediatrics (2013)

Adolescent VolunteeringA dolescent health is often affected by social factors such as connections to the family, school, and community.One way in which adolescents can establish community connections is through volunteering.Through volunteering, adolescents can also gain valuable life experiences and feel valued and important.Research has shown positive health benefits to volunteering.Volunteering has been shown to reduce depression and increase positive emotions.Volunteering has also been linked to lower risk of high blood pressure.In a study in this month's JAMA Pediatrics, adolescents were split into 2 groups.Half of the adolescents were in an intervention group (a group that has a particular experience) in which they provided volunteer help to younger children on a weekly basis.The other half of the adolescents were in the control group (a group that has only their normal experience) and did not volunteer.The research study found that adolescents who experienced volunteering were more likely to have lower cholesterol levels and lower body mass index compared with those who did not volunteer.This research study clearly shows positive health effects of volunteer work.There are many types of volunteer work available to adolescents.Some options may include:v School-based volunteer programs in which older adolescents help younger children.These may include supervising after-school clubs, helping younger children with their homework, or helping with a school sports team.v Hospital volunteer programs in which adolescents may help with activities such as deliveries to patient rooms, reading to patients, or helping to prepare snacks.v Animal volunteer programs with animal shelters, humane societies, or the local zoo.v Environmental volunteer programs to restore, clean, or preserve the outdoors.v Nursing home volunteer programs in which adolescents may help with reading, writing letters, or playing games.v Community organizations such as food banks, charity auctions, museums, libraries, or youth-based organizations such as the Boys & Girls Clubs of America.
BMA annual meeting: Proposed junior contract is a good deal, Malawana says
Authors: Abi Rimmer
Journal: BMJ (2016)

The chair of the BMA’s Junior Doctors Committee has said that the proposed new contract for junior doctors in England was a good deal.

Speaking at the BMA’s annual representatives meeting in Belfast on Thursday 23 June, Johann Malawana said that he recognised that juniors had different views on the contract but that he thought it was a good deal.

Junior doctors and final …
False-Positive 131I Uptake in a Benign Bone Lesion on Post-therapy Scan
Authors: Bulent Yazici, Aylin Oral, Cenk Eraslan, Mehmet Argin, Özgür Ömür
Journal: Clinical Nuclear Medicine (2015)

A 56-year-old woman underwent near-total thyroidectomy and papillary thyroid carcinoma without extrathyroidal extension was diagnosed. The serum thyroglobulin (Tg) level was 2.4 µg/L, and anti-Tg was negative when serum thyroid-stimulating hormone level was 85 µIU/mL. She received 100 mCi (3.7 GBq) of 131I. Besides the residual thyroid tissue, a focal uptake in the left clavicular bone was seen on posttherapy 131I images. Then, CT and MRI were performed to diagnosis. All imaging findings suggested that it was a benign bone cyst. At 6-month follow-up, the serum Tg level was undetectable with the thyroid-stimulating hormone level of more than 150 µIU/mL.