tbuckley/cabot-search huggingface dataset:
The liver function assessment: The indocyanine green retention in correlation with the cholescintigraphic measurement—Retrospective validation study in 107 patients with liver malignancies.
Authors: Jiri Tomasek, Igor Kiss, Jiri Prasek, Ladislav Dusek, Stepan Tucek, Vlastimil Valek, Rostislav Vyzula, Zdenek Kala, Iveta Zimova, Jan Podhorec, Jana Halamkova, Dagmar Adamkova Krakorova
Journal: Journal of Clinical Oncology (2013)

155 Background: The transarterial chemoembolization (TACE) and the radiofrequency ablation (RFA) are the keystones of interventional therapy of primary and secondary liver malignancies in oncology. A compromised liver function may be a relative contraindication to these therapies. Child-Pugh liver scoring system is widely used to exclude patients with low liver function. The indocyanine green (ICG) retention rate at 15 min. (ICGR15) is a frequently used liver function test in liver surgery, however it is not widely available. The quantification of dynamic cholescintigraphy and the calculation of hepatic extraction fraction (HEF) describes specifically a functional efficiency of the liver parenchyma. Methods: We retrospectively studied 107 patients with primary or secondary liver malignancies who underwent TACE or RFA between February 2005 and February 2012. ICG test and dynamic cholescintigraphy and Child-Pugh score were assessed before the procedure. The comparison of relative frequencies of categories was performed by binomial test (independent testing) or by McNemar’s test (paired design). The association in occurrence of different categories was tested by the help of Fisher’s exact test. Results: The comparison of categorized outcomes of ICGR15 and HEF examination revealed high degree of agreement between these techniques (p = 0.773). The statistically significant similarity in the outcome of both methods was also proved by the analysis of contingency tables. 81% of tested samples obtained the same scoring by both approaches. Clinically important discrepancies between these methods were rare and were not observed in the two extreme categories, i.e. normal and very low liver function. Conclusions: The ICGR15 correlates well with the HEF in liver function assessment. Thus either method can be used in patients who are to undergo liver directed therapies when the assessment by Child-Pugh score is not sufficient enough.
S129 What proportion of patients with lung cancer would have been eligible for ct screening according to various proposed inclusion criteria?
Authors: K Gracie, M Kennedy, D Ellames, B Hawramy, A Al-Ameri, G Esterbrook, P Blaxill, G Smith, P Smith, R Naseer, K Rodger, J Robson, E Paramasivam, M Callister
Journal: Thorax (2016)

<h3>Abstract</h3> The US National Lung Screening Trial (NLST) identified persons for lung cancer screening by age (55–74 yrs) and smoking history, but a subsequent analysis of the US SEER database showed that only 26.7% of lung cancer cases would have been eligible for screening according to these criteria. Strategies to increase the proportion of lung cancer patients who might qualify for screening include increasing the upper age limit to 80 years (endorsed by the US Preventative Services Task Force – USPSTF), and using composite lung cancer risk prediction tools. The UK Lung Screening pilot (UKLS) used the Liverpool Lung Project score (LLP) to identify patients for screening. In a validation cohort from the US Prostate, Lung, Colorectal and Ovarian study, a threshold based on the PLCO<sub>M2012</sub> score identified more cancers than the NLST criteria. We prospectively compared these criteria for the first time in patients presenting with lung cancer in Yorkshire. <h3>Methods</h3> We audited the proportion of patients presenting with lung cancer through fast-track clinics at 4 Yorkshire centres who would have been eligible for screening according to the following criteria: NLST criteria, UKLS criteria, USPSTF criteria, LLP ≥5% 55–80 yrs, and PLCO ≥1.51% 55–80 yrs. <h3>Results</h3> Data was collected for 206 patients presenting between January and July 2016 (Leeds 131, Halifax 26, Bradford 12, Mid-Yorkshire 37). Median age was 72 years and the proportion of cases by age cohort was as follows: &lt;55 yrs 9.2%, 55–60 yrs 9.7%, 61–65 yrs 12.1%, 66–70 yrs 13.6%, 71–75 yrs 18.4%, 76–80 yrs 17.0%, &gt;80 yrs 19.9%. Smoking status was: current smoker 89 (43.2%), ex-smoker 106 (51.5%) and never smoker 11 (5.3%). The number of patients eligible by the various criteria are shown in Table 1. <h3>Conclusion</h3> The proportion of lung cancer patients who would have been eligible for screening differs considerably between the various criteria. Only approximately one third of patients would have been eligible according to the criteria used in NLST and UKLS. Increasing the upper age limit for screening to 80yrs substantially increases the proportion of cases that would be eligible. A threshold of 1.51% by the PLCO<sub>M2012</sub> score included the largest number of lung cancer patients of the criteria assessed.
Inducible MyD88/CD40 Enhances Proliferation and Survival of PRAME-Specific TCR-Engineered T Cells and Increases Anti-Tumor Effects in Myeloma
Authors: Tsvetalina Hoang, Aaron Foster, Jeannette Crisostomo, An Lu, Annemarie Moseley, Mirjam H.M. Heemskerk, Kevin M Slawin, David M Spencer
Journal: Blood (2015)
Intravenous Forodesine (BCX-1777), a Novel Purine Nucleoside Phosphorylase (PNP) Inhibitor, Demonstrates Clinical Activity in Patients with Refractory Cutaneous T-Cell Lymphoma.
Authors: Madeleine Duvic, Francine M. Foss, Elise A. Olsen, Andres Forero-Torres, J. Claude Bennett, Shanta Bantia, J. Michael Kilpatrick
Journal: Blood (2004)
P179 Antecedents of asthma admissions in children: a whole population linkage study
Authors: S Thomas, L Turner
Journal: Thorax (2016)

<h3>Introduction</h3> Asthma is a complex condition where early respiratory infections are implicated in causation. However, the literature is not always supportive of the paradigm that early respiratory infection increases the risk for later asthma. Here, we test the hypothesis that hospital admission with bronchiolitis or lower respiratory tract infection (LRTI) before age two is associated with increased risk for an asthma admission after two years of age. <h3>Method</h3> Details of all paediatric admissions to Scottish hospitals 2000–2013 were obtained. Admissions with bronchiolitis, LRTI and asthma were identified. Each individual had a unique identifier which allowed linkage of admissions. <h3>Results</h3> There were 329211 admissions, including 28856 with bronchiolitis, 8558 with LRTI and 14734 with asthma. 2.7% of those with a bronchiolitis admission and 3.8% with a LRTI admission had a later asthma admission (see Table 1). Compared to zero previous bronchiolitis admissions, one admission was associated with a reduced risk for asthma admission (odds ratio [OR] 0.71 [95% CI: 0.65, 0.77] but this risk increased after two bronchiolitis admissions (1.19 [95% CI: 0.99, 1.41]) and after ≥3 admissions (OR 1.52 [95% CI: 1.11, 2.08]). One prior LRTI admission was associated with a borderline increased OR for a later asthma admission (1.12 [95% CI: 0.99, 1.26]) compared to no admissions, and the OR after two previous admissions was 1.49 ([95% CI: 1.05, 2.13]). HDU admission with bronchiolitis or LRTI was not associated with increased risk of later asthma admission. <h3>Conclusion</h3> The relationship between early respiratory infections requiring hospitalisation, and later asthma admissions is complex. There is no consistent evidence that hospitalisation with respiratory infections in early life is causally linked to risk of later asthma admissions. However, repeated hospitalizations with infections may be linked to later asthma admissions by reverse causation.
Manteinance Treatment with Interferon (IFN) Is Not Necessary to Achieve Prolonged Progression Free Survival (PFS) in Patients with Indolent Non Hodgkin’s Lymphoma (NHL). Results from a Prospective Randomized Trial on 165 Patients.
Authors: Jimena Cannata, Concepcion Nicolas, Raul Cordoba Resident, Consuelo Rayon, Jose Garcia-Laraña, Javier Lopez, Guillermo Perez, Pedro Sanchez-Godoy, Pilar Garcia-Alfonso, Pilar Zamora, Jose-Maria Fernandez-Rañada, Reyes Arranz
Journal: Blood (2004)
Cancer-related memory problems, demographic, and socioeconomic backgrounds: A cross-sectional study of the United States population.
Authors: P. Jean-Pierre, P. Winters, T. Ahles, M. Antoni, D. Armstrong, F. Penedo, S. E. Lipshultz, T. L. Miller, K. Fiscella
Journal: Journal of Clinical Oncology (2011)

9084 Background: Cancer-related neurocognitive dysfunction (CRND) (e.g., memory impairments) can negatively affect psychosocial functioning and quality of life for patients and survivors. However, studies on the relationships between CRND and socioeconomic and demographic backgrounds are lacking. Methods: We examined the relationships between prevalence of CRND, and socioeconomic and demographic factors among individuals with and without a history of cancer using a nationally representative sample of the civilian, non-institutionalized United States population from the National Health and Nutrition Survey (NHANES 1999-2008). Participants answered the yes-no question “Are you limited in any way because of difficulty remembering or because you experience periods of confusion?” We controlled for age, sex, race-ethnicity, education, poverty level, and general health. Results: The sample (N=17,003) consisted of 8,358 men and 8,645 women (including 3,342 Blacks; 9,048 Whites; 3,132 Mexican Americans; and 1,481 other race/other Hispanic/multi-racial) age 40 years and older. Of these, 2,008 participants reported a history cancer. CRND was reported more often by participants with a history of cancer (12.8%) than by those without (8.1%). Having had cancer was independently associated with memory impairment (odds ratio, 1.66; 95% CI, 1.41 to 1.96). Socioeconomic status and demographic factors (e.g., age, annual household income and general health) predicted higher risks of memory impairment (p<0.05 for all). Participants less than 55 years (p<0.004), with higher income (p<0.01), and good to excellent general health (p<0.002) reported more memory problems. Conclusions: Memory impairment is a significant side effect of cancer/cancer treatment. Socioeconomics and demographics predicted higher risks of CRND.
First Report of the Phase III North American Trial of Decitabine in Advanced Myelodysplastic Syndrome (MDS).
Authors: Hussain Saba, Craig Rosenfeld, Jean-Pierre Issa, John DiPersio, Azra Raza, Virginia Klimek, James Slack, Carlos de Castro, Karl Mettinger, Hagop Kantarjian
Journal: Blood (2004)
BCL2L10 (Bcl-B) Is Associated with Resistance to Azacitidine (AZA) in MDS and AML, and Is a Possible Therapeutic Target in AZA Resistant Patients
Authors: Thomas Cluzeau, Guillaume Robert, Jean-Michel Karsenti, Frederic Luciano, Alexandre Puissant, Faezeh Legrand, Lionel Mannone, Aline Renneville, Claude Preudhomme, Pierre Fenaux, Jill-Patrice Cassuto, Sophie Raynaud, Nicolas Mounier, Patrick Auberger
Journal: Blood (2012)
The Anti-Tumor Effects of SU11248, a Class III Receptor Tyrosine Kinase Inhibitor, Against a Variety of Human Hematological Malignancies.
Authors: Takayuki Ikezoe, Kentaro Bandobashi, Yang Yang, Tsuyako Saito, Kazuto Togitani, Taizo Tasaka, H. Phillip Koeffler, Hirokuni Taguchi
Journal: Blood (2005)
Immunophenotyping to Detect Minimal Residual Disease in Adult Acute Lymphoblastic Leukemia - Feasibility and Prognostic Significance.
Authors: Jerzy Holowiecki, Sebastian Giebel, Krystyna Jagoda, Malgorzata Krawczyk-Kulis, Beata Stella-Holowiecka, Slawomira Kyrcz-Krzemien, Monika Paluszewska, Malgorzata Kopera, Wlodzimierz Medrek, Grazyna Bober, Jacek Najda
Journal: Blood (2004)
Grilled, Barbecued, and Smoked Meat Intake and Survival Following Breast Cancer
Authors: Humberto Parada, Susan E. Steck, Patrick T. Bradshaw, Lawrence S. Engel, Kathleen Conway, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella, Marilie D. Gammon
Journal: JNCI Journal of the National Cancer Institute (2016)

Background: Grilled, barbecued, and smoked meat intake, a prevalent dietary source of polycyclic aromatic hydrocarbon (PAH) carcinogens, may increase the risk of incident breast cancer. However, no studies have examined whether intake of this PAH source influences survival after breast cancer. Methods: We interviewed a population-based cohort of 1508 women diagnosed with first primary invasive or in situ breast cancer in 1996 and 1997 at baseline and again approximately five years later to assess grilled/barbecued and smoked meat intake. After a median of 17.6 years of follow-up, 597 deaths, of which 237 were breast cancer related, were identified. Multivariable Cox regression was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality as related to prediagnosis intake, comparing high (above the median) to low intake, as well as postdiagnosis changes in intake, comparing every combination of pre-/postdiagnosis intake to low pre-/postdiagnosis intake. All statistical tests were two-sided. Results: High prediagnosis grilled/barbecued and smoked meat intake was associated with increased risk of all-cause mortality (HR = 1.23, 95% CI = 1.03 to 1.46). Other associations were noted, but estimates were not statistically significant. These include high prediagnosis smoked beef/lamb/pork intake and increased all-cause (HR = 1.17, 95% CI = 0.99 to 1.38, Ptrend = .10) and breast cancer–specific (HR = 1.23, 95% CI = 0.95 to 1.60, Ptrend = .09) mortality. Also, among women with continued high grilled/barbecued and smoked meat intake after diagnosis, all-cause mortality risk was elevated 31% (HR = 1.31, 95% CI = 0.96 to 1.78). Further, breast cancer–specific mortality was decreased among women with any pre- and postdiagnosis intake of smoked poultry/fish (HR = 0.55, 95% CI = 0.31 to 0.97). Conclusion: High intake of grilled/barbecued and smoked meat may increase mortality after breast cancer.
P1.08-022 Risk Stratification Model to Predict Survival Following Surgical Resection for Lung Cancer Using Pathological Variables
Authors: Timothy Edwards, Charlene Tennyson, Haval Balata, Phil Foden, Anshuman Chaturvedi, Rajesh Shah, Philip Crosbie, Richard Booton, Matthew Evison
Journal: Journal of Thoracic Oncology (2017)
Clinical and immunologic impact of CCR5 blockade in graft-versus-host disease prophylaxis
Authors: Ryan H. Moy, Austin P. Huffman, Lee P. Richman, Lisa Crisalli, Ximi K. Wang, James A. Hoxie, Rosemarie Mick, Stephen G. Emerson, Yi Zhang, Robert H. Vonderheide, David L. Porter, Ran Reshef
Journal: Blood (2017)
P3.01-038 STAT3 and Src-YAP1 Inhibition Results in Greater Necitumumab Sensitivity in Lung Squamous Cell Carcinoma
Authors: Alberto Verlicchi, Niki Karachaliou, Chiara Lazzari, Carles Codony Servat, Ana Gimenez Capitan, Jordi Codony Servat, Jordi Bertrán-Alamillo, Miguel Angel Molina Vila, Imane Chaib, José Luis Ramírez Serrano, Claudio Dazzi, Peng Cao, Rafael Rosell
Journal: Journal of Thoracic Oncology (2017)
PUB052 Proteome Signatures and New Cancer Drivers
Authors: Wen Zhang, Shingo Sakashita, Melania Pintilie, Bethany Pitcher, Jiefei Tong, Paul Taylor, Nhu-An Pham, Ming Li, Tao Wang, Michael Cabanero, Ming Tsao, Michael Moran
Journal: Journal of Thoracic Oncology (2017)
Is Time of the Essence in Adult Acute Myeloid Leukemia (AML)? Time to Blast Clearance and Time to Induction Therapy Fail to Predict Overall Survival (OS).
Authors: Holbrook E Kohrt, Samit Patel, Michelle Ho, Terri Owen, Ravindra Majeti, Jason R. Gotlib, Steve Coutre, Bruno C. Medeiros, Ash A Alizadeh
Journal: Blood (2009)
Targeting Vla-4 Reduces Cell Adhesion Mediated Drug Resistance in Chronic Lymphocytic Leukemia: Rationale for Anti Vla-4 Therapy.
Authors: Grzegorz S. Nowakowski, Thomas E. Witzig, Nancy D. Bone, Yean K. Lee, Tait D. Shanafelt, Neil E. Kay
Journal: Blood (2005)
MA06.01 Overall Survival Characterization of Incidental N2 Non-Small Cell Lung Cancer over 14 Years at a Single Canadian Institution
Authors: Cara Van Der Merwe, Adrijana D'Silva, Shannon Otsuka, Gary Gelfand, Andrew Graham, Sean Grondin, Sean Mcfadden, Gwyn Bebb
Journal: Journal of Thoracic Oncology (2017)
P254 Validation of telemedicine spirometry
Authors: R Peat, P Szymczyk, D Russell, D Nazareth, M Shaw, MJ Walshaw
Journal: Thorax (2016)

<h3>Introduction</h3> Spirometry is considered one of the most important tests for the monitoring of CF and is commonly performed at each clinic visit. With the emerging appetite for telemedicine as a viable alternative to traditional hospital outpatient visits, the suitability of an inexpensive handheld spirometer was assessed for home use. <h3>Methods</h3> We compared the accuracy of a handheld spirometer (COPD6, Vitalograph, UK) with a standard laboratory based spirometer (Spirostik, Geratherm, Germany) in 41 consecutive adult CF patients (mean age 39 years [SD 11.4], mean predicted FEV1 60% [23], 16 male) attending our regional CF centre. All were experienced at performing spirometry. They were randomly assigned to either device and carried out 3 manoeuvres before repeating the test session the alternative spirometer. Both testing sessions were supervised and performed in the same clinic room. Patient coaching and feedback was withheld from the handheld spirometry session. Intra-session analysis of flow volume tracings was carried out for lab based testing sessions. <h3>Results</h3> Acceptable paired results were obtained in 36 patients (88%). The mean Spirostik FEV1 was 2.14L (variability 0.06 [2.3%]) and COPD6 2.02L (variability 0.09 [4.4%]); mean difference between devices 0.12L (5.6%). Eight of 36 (22%) results were lower on the handheld device. Analysis of the flow volume tracing was required for 6 patients (16%) to either improve technique (3), or QC/eliminate artefact (3): where artefact was not eliminated, FEV1 was overestimated by 0.08 to 0.09L (∼4.5%). <h3>Conclusions</h3> The handheld device was easy to operate and accuracy and repeatability was considered to be acceptable for a telemedicine/home use application. However, differences between traditional clinic/laboratory spirometry results and telemedicine spirometry results were observed. When comparing spirometry results clinicians should have an appreciation of expected differences. Additional variables may exist where patients are unsupervised in a home setting.
Champions' league of professional educational opportunities: Helsinki June 2017
Authors: Karim M Khan
Journal: British Journal of Sports Medicine (2017)

I love Google images. Have you tried it? Put in ‘Helsinki’ and you see a wonderful mix of old and new; historical grandeur and contemporary elegance. I have to confess to having a soft spot for Finland and the Finns. My love affair began in 1995 with Professor Pekka Kannus, Sports physician, PhD, with prolific research publications including the classic bone mineral density studies in female adolescent tennis players. Up to 20% side-to-side differences in the forearms of those girls started playing before puberty;1 half to a quarter the difference if they began playing at or after puberty. Not dependent on hours per week of tennis, the window of opportunity is quality research, innovative study design and impactful.

If Finland were a character in a movie, she/he would not be a scene stealer like Meryl Streep, Halle Berry, Robin Williams or Denzel Washington. Finland would be played by Anna Kendrick or William H Macy. It is …
P3.03-048 Profiling Response to Chemotherapy in Malignant Pleural Mesothelioma among Hispanics (MeSO-CLICaP)
Authors: Andrés Cardona, Oscar Arrieta, Leonardo Rojas, Luis Corrales, Beatriz Wills, George Oblitas, Ludwing Bacon, Claudio Martin, Mauricio Cuello, Luis Mas, Carlos Vargas, Hernan Carranza, Jorge Otero, Maria Perez, Lisde González, Luis Chirinos, Rafael Rosell
Journal: Journal of Thoracic Oncology (2017)
Effect of irradiation of renal cell carcinoma (RCC) cell lines on RCC tumor-associated antigen (TAA) specific CD8+ T-cell stimulation.
Authors: Gregory Janda, Mohammad Habiby Kermany, Michelle Romano, Lilia Heit, Anurag Singh, Graham Walter Warren, Thomas Schwaab
Journal: Journal of Clinical Oncology (2014)

542 Background: Radiation increases the immunogenicity of many cancers. We have previously shown increased immunogenicity of RCC with cell line irradiation. Herein, we describe the effect of irradiation of RCC cell lines on the expression of TAAs as well as several molecules involved in CD8+ T Cell (CTL) mediated tumor cytotoxicty and the in vitro effect of tumor irradiation on NY-ESO-1 specific CTL clones. Methods: Six RCC cell lines (ACHN, 786-0, 769-P, Caki-1, A-498, A-704) were cultured and exposed to 0, 12 or 16 Gy of ionizing radiation. Cells were isolated at 2, 24 and 48 hours after irradiation. Expression of cell surface molecules (CD95, CD54, Calreticulin, NYESO-1, CA-9, 5T4, MUC-1 and HSP-70) was assessed using multi-color flow cytometry. Results are reported as mean relative increase from control (dose 0 Gy, time 2 hours post irradiation). In a second experiment, NY-ESO-1 specific CTL clones were cultured in the presence of A-498 cells that were subjected to radiation under the above noted conditions and assessed using an ELISPOT assay. Negative control consisted of only CD8+ T Cells. Results: The ELISPOT experiment demonstrated stimulation of NY-ESO-1-specific CTL by irradiated A-498 cells. Negative control showed no stimulation, with only 4 spots. An increase in spots was observed from 79 and 82 spots at 2 hours post-irradiation to 166 and 205 spots at 48 hours post-irradiation for 0 Gy and 16 Gy, respectively. Conclusions: Sublethal irradiation of human RCC cell lines increases their immunogenicity, provoking TAA-specific T cell stimulation. [Table: see text]
The Role of Extent of Surgical Resection and Lymph Node Assessment for Clinical Stage I Pulmonary Lepidic Adenocarcinoma: An Analysis of 1991 Patients
Authors: Morgan L. Cox, Chi-Fu Jeffrey Yang, Paul J. Speicher, Kevin L. Anderson, Zachary W. Fitch, Lin Gu, Robert Patrick Davis, Xiaofei Wang, Thomas A. D’Amico, Matthew G. Hartwig, David H. Harpole, Mark F. Berry
Journal: Journal of Thoracic Oncology (2017)
Unexplained isolated hyperferritinemia without iron overload
Authors: Giulia Ravasi, Sara Pelucchi, Raffaella Mariani, Marco Casati, Federico Greni, Cristina Arosio, Irene Pelloni, Silvia Majore, Paolo Santambrogio, Sonia Levi, Alberto Piperno
Journal: American Journal of Hematology (2017)

Although hyperferritinemia may be reflective of elevated total body iron stores, there are conditions in which ferritin levels are disproportionately elevated relative to iron status. Autosomal dominant forms of hyperferritinemia due to mutations in the L-ferritin IRE or in A helix of L-ferritin gene have been described, however cases of isolated hyperferritinemia still remain unsolved. We describe 12 Italian subjects with unexplained isolated hyperferritinemia (UIH). Four probands have affected siblings, but no affected parents or offspring. Sequencing analyses did not identify casual mutations in ferritin gene or IRE regions. These patients had normal levels of intracellular ferritin protein and mRNA in peripheral blood cells excluding pathological ferritin production at transcriptional and post-transcriptional level. In contrast with individuals with benign hyperferritinemia caused by mutations affecting the ferritin A helix, low rather than high glycosylation of serum ferritin was observed in our UIH subjects compared with controls. These findings suggest that subjects with UIH have a previously undescribed form of hyperferritinemia possibly attributable to increased cellular ferritin secretion and/or decreased serum ferritin clearance. The cause remains to be defined and we can only speculate the existence of mutations in gene/s not directly implicated in iron metabolism that could affect ferritin turnover including ferritin secretion.