tbuckley/cabot-search huggingface dataset:
SAT0592 Peak-Incidence Age in Rheumatoid Arthritis Has Not Shifted in Finland since The Turn of Millennium:
Authors: K. Puolakka, V. Rantalaiho, H. Kautiainen
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Over the recent decades several studies have observed a shift towards higher age at disease onset in the incidence of rheumatoid arthritis (RA). The cause of this phenomenon is unknown. <h3>Objectives</h3> To find out whether the peak-incidence age has still been increasing during this millennium. <h3>Methods</h3> From the nationwide drug reimbursement register maintained by the Finnish Social Insurance Institution we collected data on all patients with incident inflammatory rheumatic diseases from January 1st 2000 to December 31st 2014. Patients with incident RA were identified by the ICD-10 codes of M05 and M06. The peak-incidence age of this cohort was modelled using the Poisson regression with restricted cubic splines (5 knots). <h3>Results</h3> During the observation time altogether 27 764 patients (mean age 61.3 at disease onset, 67.5% female) with a new diagnosis of RA were identified. Table shows the peak-incidence ages as well as mean ages at disease onset during the whole observation time and by 3-year periods. The peak-incidence age remained stable over the 15 years since the turn of millennium. The mean age at disease onset increased slightly in male. <h3>Conclusions</h3> These results suggest that the unknown factors in the population and environment behind the earlier observed shift towards higher age in the incidence of RA have no longer been gaining power during the 21th century. <h3>Disclosure of Interest</h3> None declared
Teen vaping is linked to higher odds of heavy cigarette smoking
Authors: Jacqui Wise
Journal: BMJ (2016)

Teenagers who frequently use e-cigarettes have higher odds of being heavier cigarette smokers after six months than those who use the devices less often, a research letter published in JAMA has shown.1

The US study, funded by the National Institutes of Health, included 3084 adolescents with an average age of 15.5 years from 10 state high schools in Los Angeles County, California. Researchers divided …
Allogeneic Hematopoietic Stem Cell Transplantation Is an Effective Salvage Therapy for Patients with Chronic Myeloid Leukemia Failing Treatment with Tyrosine Kinase Inhibitors
Authors: Anish Nair, Michael J Barnett, Donna E. Hogge, Kevin Song, Cynthia L. Toze, Stephen H. Nantel, Maryse M Power, Sujaatha Narayanan, Raewyn Broady, Heather J. Sutherland, Thomas J. Nevill, Yasser R Abou Mourad, Alina S. Gerrie, Donna L. Forrest
Journal: Blood (2014)
Leukemia Stem Cells in Acute Lymphoblastic Leukemia: Unveiling Hierarchical Structure at Single Cell Resolution
Authors: Noriko Satake, Connie Duong, Sakiko Yoshida, Ryan Davis, Stephenie Liu, Jonathan Van Dyke, Bridget McLaughlin, Jan A. Nolta, Nitin Nitin, Cliff Tepper
Journal: Blood (2014)
Alemtuzumab-Cyclosporine Versus Tacrolimus-Methotrexate-Sirolimus for Graft-Versus-Host Disease Prophylaxis in Reduced Intensity Allogeneic Hematopoietic Stem Cell Transplantation from Unrelated Donors: Final Results of a Randomized Trial
Authors: Lauren M. Curtis, Steven Z. Pavletic, Rachel B. Salit, Brian C Shaffer, Seth M. Steinberg, Jennifer S. Wilder, Filip Pirsl, Bazetta Blacklock-Schuver, Jennifer Hsu, Thomas E. Hughes, David Stroncek, Sharon Adams, Jennifer Hendricks, Daniele N. Avila, Jennifer Mann, David C. Halverson, Thea M. Friedman, Robert Korngold, Juan C. Gea-Banacloche, Daniel H. Fowler, Dennis L. Confer, Frances T. Hakim, Ronald E. Gress, Michael R. Bishop
Journal: Blood (2015)
AB0974 High-Field MRI: Infra-Radiological Structural Abnormalities Detection in Wrist of Patients with Spondyloarthritis and Early Rheumatoid Arthritis
Authors: S. Guis, P. Souteyrand, D. Militianu, C. Chagnaud, Y. Le Fur, J.-P. Mattei, M. Rozenbaum, I. Rosner, H. Boudinet, M. Bernard, D. Bendahan
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Previous studies have showed that structural abnormalities such as erosions and geodes could be detected in wrist of patients with Rheumatoid Arthritis (RA) using high-field MRI whereas corresponding anomalies were invisible using conventional 1.5 T MRI. Similar observations have not been reported so far for patients with either an early form of RA or patients with axial and peripheral forms of spondyloarthritis (SpA). <h3>Objectives</h3> In the present study, we compared wrist MRI investigations performed at 1.5 and 3 T in SpA and early RA patients (less than one-year disease evolution). We aimed at determining whether synovitis, geodes and erosions are similarly observed in both cases. <h3>Methods</h3> The study was conducted in the wrist of 9 SpA patients (6 with ankylosing spondyloarthritis (AS) and 3 with psoriatic arthritis) and in 7 early RA patients. Age in the RA group ranged from 35 to 54 (6 females, 1 male) while it ranged between 22 and 64 in the SpA group (7 females, 2 males). All the patients provided their written informed consent before their inclusion in the protocol which was approved by the local ethics committee. MRI investigations were performed at 1.5T (Philips Achieva) using a Flex-M coil and at 3T (Siemens Verio) using a 4-channel flexible coil. In both cases, subjects were asked to lie down in the supine position inside the scanner and wrist was scanned at 1.5T using a T1-SE and a PD-FS-SE and at 3T using both a VIBE and a DESS sequences. MR images were analyzed by one senior radiologist (CC). <h3>Results</h3> In the RA group, we identified more abnormalities at 3T as compared to 1.5T for 1 patient while for 5 patients the number of abnormalities was identical in both cases. 1 patient did show no abnormality. Similarly, in the SpA group, more abnormalities were observed at 3T as compared to 1.5T for 2 patients. In those cases, more erosions were identified whereas geodes, synovitis and oedema were similar. These two patients had AS with peripheral and axial pain without psoriasis. For 1 patient with structural abnormalities, the results at both fields were similar. In 6 patients, (including 2 patients with psoriatic arthritis), we did not detect any structural abnormality. <h3>Conclusions</h3> In the present study, we illustrated that for both RA and SpA patients, MRI investigations performed at high-field can detect wrist abnormalities which were not detectable at 1.5T. <h3>Disclosure of Interest</h3> None declared
The Correlation Between Deletion Architecture, ATM Mutational Status and BIRC3 Disruption in 11q-Deleted CLL
Authors: Matthew JJ Rose-Zerilli, Jade Forster, Helen Parker, Anton Parker, Ana E Rodríguez, Tracy Chaplin, Anne Gardiner, Andrew Collins, Bryan D Young, Tatjana Stankovic, David Oscier, Jonathan C. Strefford
Journal: Blood (2012)
Cytomegalovirus Drives Acute Myeloid Leukemia Cells in Apoptosis and Reduces Thereby Markedly the Risk for Relapse after Transplant
Authors: Ahmet H Elmaagacli, Michael Koldehoff, Tania Gromke, Rudolf S Ross, Rudolf Trenschel, Sebastian Bauer, Bertram Opalka, Dietrich W Beelen
Journal: Blood (2008)
Vitamin B12 Handling by the Kidney, a Major Site of B12 Traffic: Normal and Abnormal Physiology.
Authors: Hesham Hazin, Kotresha Neelakantappa, Lakshmi Ramasahayam, Ahmed Abdel-Maksoud, Josua Fogel, Søren Kragh Moestrup, Ralph Carmel
Journal: Blood (2008)
Cytogenetic and Molecular Characterization of Sweet's Syndrome in Patients with Acute Myeloid Leukemia.
Authors: Syed M. Kazmi, Hagop M. Kantarjian, Kathy M. Tran, Jorge E. Cortes, Farhad Ravandi, Gautam Borthakur, Elias J. Jabbour, Stefan Faderl, Guillermo Garcia-Manero, Tapan M. Kadia, Naval Daver, Sherry A. Pierce, Aziz Nazha, Alfonso Quintas-Cardama, Naveen Pemmaraju
Journal: Blood (2012)
Trend in Ventilator-Associated Pneumonia Rates Between 2005 and 2013
Authors: Mark L. Metersky, Yun Wang, Michael Klompas, Sheila Eckenrode, Anila Bakullari, Noel Eldridge
Journal: JAMA (2016)

This study analyzes rates of incident ventilator-associated pneumonia reported 2005-2013 to the Medicare Patient Safety Monitoring System to determine whether those rates accord with those reported for a similar period to the CDC National Healthcare Safety Network.
Vitamin K2 (VK2) Monotherapy and VK2 Plus D3 Combination Therapy in Low-Risk Myelodysplastic Syndrome: A Prospective Japanese Study.
Authors: Keisuke Miyazawa, Kazuma Ohyashiki, Nobu Akiyama, Yoshinobu Kanda, Kaoru Tohyama, Mistuhiro Omine, Kinuko Mitani
Journal: Blood (2005)
Increased cutaneous stimulation is required for C-fiber sensory perception in alopecia areata: A double-blind study
Authors: Ronda S. Farah, Rina S. Farah, Ana Carina Junqueira Bertin, Hongfei Guo, Marna E. Ericson, Maria K. Hordinsky
Journal: Journal of the American Academy of Dermatology (2016)
The Persistance of Residual Vein Thrombosis, after an Episode of Deep Vein Thrombosis, and the Risk of New Overt Cancer and Cardiovascular Disease.
Authors: Sergio Siragusa, Alessandra Malato, Raffaela Anastasio, Ignazio Abbene, Carlo Arcara, Lucio Lo Coco, Alessandra Casuccio
Journal: Blood (2005)
SAT0344 Treatment of Non-Infectious Aortitis: Study of 32 Patients from A Single Centre
Authors: C. Fernández-Díaz, J. Loricera, C. Pena, R. Blanco, J.L. Hernández, J.M. Carril, I. Martínez-Rodríguez, A. Canga, E. Peirό, A. Corrales, V. Calvo-Río, C. González-Vela, M.Ά. González-Gay
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Non-infectious aortitis is often an underrecognised condition. Early diagnosis and treatment is crucial to prevent serious complications. Corticosteroids represent the first-line therapy of non-infectious aortitis. However, disease-modifying antirheumatic drugs (DMARDS) and/or biologic therapy are usually required. <h3>Objectives</h3> Our aim was to assess the treatment and outcome of patients diagnosed with non-infectious aortitis from a single centre. <h3>Methods</h3> Retrospective study of 32 patients (22 women/10 men) diagnosed with non-infectious aortitis based on imaging techniques. We have considered 3 groups: <i>group a)</i> patients who only received corticosteroids; <i>group b)</i> patients treated with corticosteroids and DMARDs; and <i>group c)</i> those who required biologic therapy. Results were expressed as mean±standard deviation (SD) or as median and interquartile range (IQR) as appropriate. Wilcoxon test was used to compare the study parameters at baseline and at the last visit. <h3>Results</h3> The mean age±SD of the patients was 68±11 years and the mean±SD follow-up was 24.7±22.7 months. <i>Group a)</i> included 11 patients; <i>group b)</i> 12 patients treated with methotrexate (MTX) and 2 hydroxychloroquine (in one of them associated to MTX); and <i>group c)</i> 9 patients on biologic therapy: adalimumab (ADA) (n=3), tocilizumab (TCZ) (n=5) and rituximab (RTX) (n=1). In this group, 8 patients were previously treated with DMARDS: MTX (n=7) and azathioprine (n=1). The results are shown in the TABLE. Two patients receiving MTX had to withdraw it due to raised liver function test, and two patients who were on TCZ had to discontinue it because of neutropenia. Moreover, one of them had angina pectoris related to a hypertensive episode during the third TCZ infusion. <h3>Conclusions</h3> Corticosteroids are the cornerstone of treatment of noninfectious aortitis, although frequently DMARDS (usually MTX) and sometimes biologic therapy are required. The treatment seems effective and relatively safe. <h3>Acknowledgement</h3> This study was supported by a grant from "Fondo de Investigaciones Sanitarias" PI12/00193 (Spain). This work was also partially supported by RETICS Programs, RD08/0075 (RIER) and RD12/0009/0013 from "Instituto de Salud Carlos III" (ISCIII) (Spain). <h3>Disclosure of Interest</h3> None declared
Tumor Antigens and T Cell Subpopulations: Is There Correlation Between These Two Possible Targets for Immunotherapy in Multiple Myeloma?
Authors: Walter Moises Tobias Braga, Bruna Raphaeli Silva, Fabricio de Carvalho, Veruska Lia Fook Alves, Gisele Wally Braga Colleoni
Journal: Blood (2012)
Parathyroid Hormone May Improve Autologous Stem Cell Mobilization Via the Stem Cell Niche.
Authors: Karen K. Ballen, Elizabeth J. Shpall, David Avigan, Beow Yeap, Steve McAfee, Bimalangshu R. Dey, Eyal Attar, Henry Kronenberg, Joseph H. Antin, Thomas R. Spitzer
Journal: Blood (2005)
Infographic. Best investments for physical activity
Authors: C Schiphorst, A Murray, P Kelly, C Oliver, F Bull
Journal: British Journal of Sports Medicine (2016)

Physical inactivity may well be THE fundamental public health challenge of our age. Despite compelling evidence on the health benefits of physical activity (PA),1 the combination of increasing mechanisation, digitisation, motorisation and urbanisation continues to inexorably squeeze essential PA out of our daily lives.

There is a new global target for all countries to reduce inactivity by 10% …
AB0209 Female Sex Increases The Risk of Forefoot Deformity in Patients with Rheumatoid Arthritis:
Authors: K. Inui, K. Orita, T. Okano, K. Mamoto, Y. Sugioka, M. Tada, T. Koike, H. Nakamura
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Forefoot involvement in patients with rheumatoid arthritis (RA) is common, and reported to be present in 50–90% of patients without any clear gender predisposition. However, patients with RA that undergo surgical treatment for their forefoot deformities are mostly female, which seems much higher rate than the prevalence of forefoot involvement by arthritis condition. <h3>Objectives</h3> In this study we evaluate the factors that contribute to forefoot deformity in RA, and investigate the significance of gender differences in forefoot deformity. <h3>Methods</h3> In this cross sectional study, 265 patients (530 feet) with RA (165 females) were enrolled. On AP and lateral standing radiographs of the foot, the angle formed by the first and second (M1/M2) and first and fifth metatarsal bones (M1/M5), the angle formed by the first metatarsal bone and the first proximal phalanx (HV), and the calcaneal pitch angle (CPA) were measured. Patient characteristics and laboratory tests were also analyzed for their potential association with forefoot deformity. As the indications for the surgical treatment of rheumatoid forefoot deformities are strongly influenced by the severity of the hallux valgus deformity, we therefore analyzed patient factors in relation to the measured HV angle. <h3>Results</h3> The HV angle was statistically greater in female RA patients than males. Patient age, sex, body mass index, disease duration, Steinbrocker staging, M1/M2 angle, M1/M5 angle, CPA, erythrocyte sedimentation rate, c-reactive protein, matrix metalloproteinase-3, and anti-citrullinated protein antibody measurements were correlated with the HV angle using a single regression analysis. Patient age, BMI, Steinbrocker stage, M1/M2 angle, M1/M5 angle, and the female gender were correlated independently with the HV angle. <h3>Conclusions</h3> The hallux valgus deformity observed in patients with RA was more severe in females, which was independent of other patient factors. This finding emphasizes that the female gender is a risk factor for the progression of the rheumatoid forefoot deformity. <h3>Disclosure of Interest</h3> None declared
AB0701 The Diagnostic Value of Sacroiliac Provocation Tests in Spondyloarthritis and Their Relationship with Magnetic Resonance Imaging Findings: Table 1.
Authors: S. Yilmaz, M. Cinar, H.T. Sanal, M. Cakar, S.A. Dilmen, I. Simsek
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Sacroiliac provocation tests are used in cases with a suspected diagnosis of spondyloarthritis (SpA). However, all of the studies on the diagnostic value of these physical examination tests have been carried out in non-inflammatory sacroiliac (SI) joint pathologies, and the data about the contribution of these tests in the diagnosis of SpA is poor. <h3>Objectives</h3> To investigate the role of sacroiliac provocation tests in the diagnosis of SpA, and their relation with inflammatory findings in magnetic resonance imaging (MRI). <h3>Methods</h3> 51 patients (F/M=7/44) with chronic low back and/or hip pain admitted to the rheumatology clinic were included in the study. The history of patients participating in the study were taken by a rheumatologist, and another experienced rheumatologist who is unaware of the patient9s medical information performed 5 different challenge tests for SI joints (sacroiliac compression test, sacroiliac distraction test, FABER-Patrick test, sacral thrust test, drop test) within a certain protocol. All patients were evaluated with sacroiliac MRI for the presence of acute inflammation. The sensitivity, specificity, positive predictive value, negative predictive value, positive and negative likelihood ratio (LR) and diagnostic accuracy of each physical examination methods were calculated with taking clinical diagnosis and sacroiliac MRI as the standard evidence of acute inflammation (2 different comparisons). <h3>Results</h3> 30 patients included in the study met the diagnostic criteria for SpA. Calculations related to diagnostic value of each examination method are summarized in Table 1.When data was analyzed for the diagnosis of SpA, the positive LR value of provocation tests ranged between 1.4–2.24.For the relationship between the examination findings and acute changes in SI joint MRI, LR values ranged positively between 1.1–2.79.Inflammatory back pain in history was associated with a positive LR value of 1.17 in predicting the diagnosis of SpA and a positive LR value of 1.37 in predicting acute changes in MRI. <h3>Conclusions</h3> These results show that the contribution of SI provocation tests for predicting the findings of inflammation in MRI or SpA diagnosis is extremely limited.When compared to the diagnostic accuracy of similar tests in non-inflammatory conditions of SI joint in the literature, the predictive value of provocation tests in the diagnosis of inflammatory conditions seems to be lower. <h3>Disclosure of Interest</h3> None declared
AB0644 Subclinical Hearing Loss in Systemic Sclerosis Patients: Relation To Disease Severity
Authors: T.A. Gheita, H. Fathi, M. El-Akkad
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic sclerosis (SSc) is one of the most complex systemic autoimmune diseases<sup>1</sup>. Ear involvement is not uncommon and should be taken into consideration during diagnostic and therapeutic procedures of SSc<sup>2</sup> <h3>Objectives</h3> The aim of the present study was to assess hearing in asymptomatic SSc patients and correlate the findings with clinical characteristics and disease severity. <h3>Methods</h3> The study included 35 female SSc patients and 35 matched controls. Skin thickness was assessed using modified Rodnan skin score (mRSS) and disease activity by Medsger severity score (MSS). Audiological tests including pure tone audiometry, speech audiometry, impedance audiometry and auditory brainstem response (ABR) were performed <h3>Results</h3> The mean age of patients was 40.3±6.2 years, and disease duration 7.3±4.6 years. Mild bilateral symmetrical sensorineural hearing loss (SNHL) was present in 27/35 (77.1%) mostly at high frequencies. Hearing thresholds, pure tone average and speech reception threshold were significantly higher (p=0.001) in SSc patients than in control. In those with hearing loss, word discrimination score (WDS) was lower and ABR-I delayed compared to those without (p=0.001,p&lt;0.0001 respectively) with consequently shorter inter-peak interval (IPI) I-III (p=0.01) and IPI I-V (p=0.004). In patients with hearing loss there was an increased frequency of acro-osteolysis (51.9%), telangiectasia (59.3%), arthralgia (70.4%) and peripheral neuritis (44.4%) compared to those with normal hearing. The MSS and mRSS significantly correlated with the high frequency hearing threshold and negatively with WDS. Audiometric parameters were comparable between patients with diffuse (n=14) and limited (n=21) cutaneous SSc. <h3>Conclusions</h3> Audiometric tests may detect subclinical SNHL mostly cochlear in SSc patients. The significant association between SNHL with telangiectasia and neuritis raises the likelihood that the SNHL may be due to an underlying vasculopathy or neuritis. <h3>References</h3> Pattanaik D, Brown M, Postlethwaite BC, Postlethwaite AE. Pathogenesis of Systemic Sclerosis. Front Immunol. 2015;6:272. Maciaszczyk K, Waszczykowska E, Pajor A, Bartkowiak-Dziankowska B, Durko T. Hearing organ disorders in patients with systemic sclerosis. Rheumatol Int. 2011;31(11):1423–8. <h3>Disclosure of Interest</h3> None declared
Association Between Patient-Centered Medical Homes and Adherence to Chronic Disease Medications
Authors: Julie C. Lauffenburger, William H. Shrank, Asaf Bitton, Jessica M. Franklin, Robert J. Glynn, Alexis A. Krumme, Olga S. Matlin, Edmund J. Pezalla, Claire M. Spettell, Gregory Brill, Niteesh K. Choudhry
Journal: Annals of Internal Medicine (2016)

Despite the widespread adoption of patient-centered medical homes into primary care practice, the evidence supporting their effect on health care outcomes has come primarily from geographically localized and well-integrated health systems.To assess the association between medication adherence and medical homes in a national patient and provider population, given the strong ties between adherence to chronic disease medications and health care quality and spending.Retrospective cohort study.Claims from a large national health insurer.Patients initiating therapy with common medications for chronic diseases (diabetes, hypertension, and hyperlipidemia) between 2011 and 2013.Medication adherence in the 12 months after treatment initiation was compared among patients cared for by providers practicing in National Committee for Quality Assurance-recognized patient-centered medical homes and propensity score-matched control practices in the same Primary Care Service Areas. Linear mixed models were used to examine the association between medical homes and adherence.Of 313 765 patients meeting study criteria, 18 611 (5.9%) received care in patient-centered medical homes. Mean rates of adherence were 64% among medical home patients and 59% among control patients. Among 4660 matched control and medical home practices, medication adherence was significantly higher in medical homes (2.2% [95% CI, 1.5% to 2.9%]). The association between medical homes and better adherence did not differ significantly by disease state (diabetes, 3.0% [CI, 1.5% to 4.6%]; hypertension, 3.2% [CI, 2.2% to 4.2%]; hyperlipidemia, 1.5% [CI, 0.6% to 2.5%]).Clinical outcomes related to medication adherence were not assessed.Receipt of care in a patient-centered medical home is associated with better adherence, a vital measure of health care quality, among patients initiating treatment with medications for common high-cost chronic diseases.CVS Health.
High Resolution Mass Cytometry (CyTOF) in Aplastic Anaemia (AA) Can Identify an Aberrant Treg Subset with Pro-Inflammatory Properties, Predicting Poor Response to Immunosuppressive Therapy
Authors: Shahram Kordasti, Thomas Seidl, Richard J Ellis, Austin Kulasekararaj, Xingmin Feng, Danielle M. Townsley, Susanne Heck, Neal S. Young, Judith C Marsh, Ghulam J. Mufti
Journal: Blood (2014)
Allografting for Adult T-Cell Leukemia/Lymphoma: A Nationwide Retrospective Analysis.
Authors: Masakatsu Hishizawa, Junya Kanda, Atae Utsunomiya, Shuichi Taniguchi, Tetsuya Eto, Yukiyoshi Moriuchi, Ryuji Tanosaki, Fumio Kawano, Yasushi Miyazaki, Koji Nagafuji, Masamichi Hara, Fumiaki Yoshiba, Minoko Takanashi, Shunro Kai, Yoshiko Atsuta, Takakazu Kawase, Tokiko Nagamura-Inoue, Keitaro Matsuo, Shunichi Kato, Yasuo Morishima, Jun Okamura, Yoshihisa Kodera, Takashi Uchiyama
Journal: Blood (2007)