tbuckley/cabot-search huggingface dataset:
Case 4-1968
Authors: John D. Stoeckle, Benjamin Castleman
Journal: New England Journal of Medicine (1968)

Presentation of CaseA sixty-eight-year-old woman entered the hospital because of pain in the chest.She had been well until the afternoon of admission, when there was the sudden onset of severe dyspnea and tightness across the chest. She became severely diaphoretic and within a few minutes lost consciousness.The patient had had no serious illnesses. Three years earlier she entered another hospital because of an episode of epistaxis. The blood pressure was 164 systolic, 84 diastolic. An electrocardiogram was said to be within normal limits, and she was told that she was in excellent health. She had had no . . .
CASE REPORT
Authors: SAMUEL LIEBMAN, L. WAYNE JOHNSON
Journal: American Journal of Psychiatry (1947)

A case of phenobarbital poisoning in a chronic alcoholic is reported, in which the patient is believed to have taken about 10 grams of phenobarbital and was comatose for 109 hours and lethargic for 149 hours. She received a total of 2,526 mgms. of picrotoxin. We believe this is the largest reported dose of picrotoxin used in barbiturate poisoning with recovery of the patient.
The effect of age on dexamethasone suppression test results in alcoholic patients
Authors: W H Nelson, P Sullivan, A Khan, R N Tamragouri
Journal: American Journal of Psychiatry (1986)

The authors studied the effects of age, liver function, mean corpuscular volume, and major depression on cortisol concentrations following the dexamethasone suppression test in 31 alcoholics. Only age was significantly correlated with cortisol levels, and it appeared to be an independent effect.
Interventions to strengthen the HIV prevention cascade: a systematic review of reviews
Authors: Shari Krishnaratne, Bernadette Hensen, Jillian Cordes, Joanne Enstone, James R Hargreaves
Journal: The Lancet HIV (2016)

BackgroundMuch progress has been made in interventions to prevent HIV infection. However, development of evidence-informed prevention programmes that translate the efficacy of these strategies into population effect remain a challenge. In this systematic review, we map current evidence for HIV prevention against a new classification system, the HIV prevention cascade.MethodsWe searched for systematic reviews on the effectiveness of HIV prevention interventions published in English from Jan 1, 1995, to July, 2015. From eligible reviews, we identified primary studies that assessed at least one of: HIV incidence, HIV prevalence, condom use, and uptake of HIV testing. We categorised interventions as those seeking to increase demand for HIV prevention, improve supply of HIV prevention methods, support adherence to prevention behaviours, or directly prevent HIV. For each specific intervention, we assigned a rating based on the number of randomised trials and the strength of evidence.FindingsFrom 88 eligible reviews, we identified 1964 primary studies, of which 292 were eligible for inclusion. Primary studies of direct prevention mechanisms showed strong evidence for the efficacy of pre-exposure prophylaxis (PrEP) and voluntary medical male circumcision. Evidence suggests that interventions to increase supply of prevention methods such as condoms or clean needles can be effective. Evidence arising from demand-side interventions and interventions to promote use of or adherence to prevention tools was less clear, with some strategies likely to be effective and others showing no effect. The quality of the evidence varied across categories.InterpretationThere is growing evidence to support a number of efficacious HIV prevention behaviours, products, and procedures. Translating this evidence into population impact will require interventions that strengthen demand for HIV prevention, supply of HIV prevention technologies, and use of and adherence to HIV prevention methods.FundingBill & Melinda Gates Foundation.
In Vitro and in Vivo Quantification of Exportin-1 (XPO1) Occupancy By the Oral Selective Inhibitor of Nuclear Export (SINE) Selinexor in Multiple Myeloma, Acute Myeloid Leukemia, and Healthy PBMCs
Authors: Marsha Crochiere, Boris Klebanov, Erkan Baloglu, Ori Kalid, Trinayan Kashyap, William Senapedis, Diego del Alamo, Tami Rashal, Sharon Tamir, Dilara McCauley, Robert Carlson, Michael Savona, Michael Kauffman, Sharon Shacham, Yosef Landesman
Journal: Blood (2014)
THE ETIOLOGY OF HEMOPHILIA.
Authors: J SCHMID
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
International Randomized Study of Interferon Versus STI571 (IRIS) 7-Year Follow-up: Sustained Survival, Low Rate of Transformation and Increased Rate of Major Molecular Response (MMR) in Patients (pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CMLCP) Treated with Imatinib (IM)
Authors: Stephen G O’Brien, François Guilhot, John M Goldman, Andreas Hochhaus, Timothy P Hughes, Jerald P. Radich, Marc Rudoltz, Jeiry Filian, Insa Gathmann, Brian J. Druker, Richard A. Larson
Journal: Blood (2008)
Beyond Folklore
Authors: Daniel W Fitzgerald, Frieda M T F Behets
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Blood lipids influence DNA methylation in circulating cells
Authors: Koen F. Dekkers, Maarten van Iterson, Roderick C. Slieker, Matthijs H. Moed, Marc Jan Bonder, Michiel van Galen, Hailiang Mei, Daria V. Zhernakova, Leonard H. van den Berg, Joris Deelen, Jenny van Dongen, Diana van Heemst, Albert Hofman, Jouke J. Hottenga, Carla J. H. van der Kallen, Casper G. Schalkwijk, Coen D. A. Stehouwer, Ettje F. Tigchelaar, André G. Uitterlinden, Gonneke Willemsen, Alexandra Zhernakova, Lude Franke, Peter A. C. ’t Hoen, Rick Jansen, Joyce van Meurs, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Erik W. van Zwet, P. Eline Slagboom, J. Wouter Jukema, Bastiaan T. Heijmans
Journal: Genome biology (2016)

Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To interrogate the causal relationship between triglyceride, low-density lipoprotein (LDL) cholesterol, and high-density lipoprotein (HDL) cholesterol levels and genome-wide DNA methylation while excluding confounding and pleiotropy, we perform a stepwise Mendelian randomization analysis in whole blood of 3296 individuals. This analysis shows that differential methylation is the consequence of inter-individual variation in blood lipid levels and not vice versa. Specifically, we observe an effect of triglycerides on DNA methylation at three CpGs, of LDL cholesterol at one CpG, and of HDL cholesterol at two CpGs using multivariable Mendelian randomization. Using RNA-seq data available for a large subset of individuals (N = 2044), DNA methylation of these six CpGs is associated with the expression of CPT1A and SREBF1 (for triglycerides), DHCR24 (for LDL cholesterol) and ABCG1 (for HDL cholesterol), which are all key regulators of lipid metabolism. Our analysis suggests a role for epigenetic priming in end-product feedback control of lipid metabolism and highlights Mendelian randomization as an effective tool to infer causal relationships in integrative genomics data.
Interrater reliability of ratings of delusions and bizarre delusions
Authors: R Mojtabai, R A Nicholson
Journal: American Journal of Psychiatry (1995)

The authors evaluated the interrater reliability of ratings of bizarre delusions, addressing limitations of previous studies.Fifty randomly selected psychiatrists rated bizarre delusions in 30 case vignettes adapted from a previous study by Spitzer and associates. Estimates of reliability were obtained for definitions of bizarre delusions in the DSM-III, DSM-III-R, and draft DSM-IV criteria for schizophrenia and for the clinicians grouped according to their current and previous experience with psychotic patients.The kappas for ratings of bizarre delusions according to the different definitions and among clinicians with different levels of experience were in the moderate to fair range.The reliability of ratings of bizarre delusions appears to be less than satisfactory for clinical practice, and the increased weight given to this symptom in modern diagnostic systems does not seem justifiable.
Use of Arteriography in the Study of Tumors
Authors:  DEN HERDERBA
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Effects of Certain Amino Acid Derivatives on Microorganisms and Sarcoma 180&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: M. N. Mickelson, Reid S. Flippin
Journal: JNCI Journal of the National Cancer Institute (1958)

Effects of Certain Amino Acid Derivatives on Microorganisms and Sarcoma 180 Get access M. N. Mickelson, M. N. Mickelson Chemistry Division, Midwest Research Institute, Kansas City, Missouri Search for other works by this author on: Oxford Academic PubMed Google Scholar Reid S. Flippin Reid S. Flippin Chemistry Division, Midwest Research Institute, Kansas City, Missouri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 20, Issue 3, March 1958, Pages 495–512, https://doi.org/10.1093/jnci/20.3.495 Published: 01 March 1958 Article history Received: 26 June 1957 Published: 01 March 1958
The quantification of epidermal growth factor receptor (EGFR) in plasma is a prognostic factor in advanced non-small cell lung cancer (NSCLC) patients
Authors: C. Camps, R. Sirera, M. Muñoz-Navarro, G. Lopez-Vivanco, G. Alonso, M. Provencio, J. Gonzalez-Larriba, R. de las Peñas, M. Taron, R. Rosell
Journal: Journal of Clinical Oncology (2007)

7597 Background: EGFR has an extracellular ligand-binding domain that can be proteolitically cleaved from the cell surface and can be accurately quantified in blood by ELISA. We have investigated the usefulness of plasma EGFR measurements as prognostic marker in advanced NSCLC. Methods: The cohort consisted in 329 patients (p) with advanced NSCLC that received first-line therapy with cisplatin and docetaxel. The concentration levels of the EGFR extracellular binding domain were determined by a sandwich quantitative ELISA in the baseline, before therapy. Results: Median age was 61, range [39–80], 84% males, 100% caucasian, 68% stage IIIB and 32% IV and 99% PS 0–1. The histological subtypes were: 31% squamous cell carcinoma, 49% adenocarcinoma, 15% large cell, and 5% undifferentiated. 181 p achieved complete response (CR), partial response (PR) or stable disease (SD) and 109 p progressive disease (PD). Median patient's plasma levels of EGFR were 32.4 ng/ml. There were not differences in p according to histology, site of metastasis and ECOG. There were differences in response to therapy; CR+PR+SD p presented median EGFR of 31.97 ng/ml [13.2–48.6] vs 30 ng/ml [16.9–46.8] in the PD group (p=0.024). Dividing the cohort in two sets according to EGFR median we found two significantly different groups in terms of Overall Survival (OS) and Time To Progression (TTP). Patients with EGFR&lt;32.4 ng/ml had a median TTP of 3.9 months (m) [3.3–4.6] while for EGFR&gt;32.4 ng/ml was 4.7 m [4.0–5.4], (p=0.024). OS when EGFR&lt;32.4 ng/ml was 6.9 m [5.9–7.8] and for EGFR&gt;32.4 ng/ml was 9.1 m [8.2–10.1], (p=0.038). Conclusions: Patients with PD presented significantly lower levels of serum EGFR than those patients with CR+PR+SD. There is a relationship among lower EGFR concentration in serum with a worst prognosis in advanced NSCLC p in terms of TTP and OS. No significant financial relationships to disclose.
La surveillance c'est l'action !
Authors: J C Desenclos
Journal: Eurosurveillance (1999)

La surveillance doit mener a l’action : telle est sa philosophie et sa justification en sante publique. La surveillance de la legionellose illustre parfaitement ce postulat. La maladie est transmise par des aerosols contamines, a partir d’un reservoir de germes hydriques. L’environnement moderne urbain favorise la multiplication du germe dans de nombreux gites ou de l’eau chaude stagne. Au fil des epidemies, la traque des sources de contamination a permis d’identifier de multiples sources et des mesures de controles ont pu etre developpees pour les installations d’eaux chaudes et les systemes de climatisation. Cette infection continue cependant de provoquer des epidemies communautaires graves, comme le montre ce numero d’Eurosurveillance (1,2,3). Des progres restent donc a faire.
Association of Higher Consumption of Foods Derived From Subsidized Commodities With Adverse Cardiometabolic Risk Among US Adults
Authors: Karen R. Siegel, Kai McKeever Bullard, Giuseppina Imperatore, Henry S. Kahn, Aryeh D. Stein, Mohammed K. Ali, K. M. Narayan
Journal: JAMA Internal Medicine (2016)

<h3>Importance</h3> Food subsidies are designed to enhance food availability, but whether they promote cardiometabolic health is unclear. <h3>Objective</h3> To investigate whether higher consumption of foods derived from subsidized food commodities is associated with adverse cardiometabolic risk among US adults. <h3>Design, Setting, and Participants</h3> Cross-sectional analysis of the National Health and Nutrition Examination Survey data from 2001 to 2006. Our final analysis was performed in January 2016. Participants were 10 308 nonpregnant adults 18 to 64 years old in the general community. <h3>Exposure</h3> From a single day of 24-hour dietary recall in the National Health and Nutrition Examination Survey, we calculated an individual-level subsidy score that estimated an individual’s consumption of subsidized food commodities as a percentage of total caloric intake. <h3>Main Outcomes and Measures</h3> The main outcomes were body mass index (calculated as weight in kilograms divided by height in meters squared), abdominal adiposity, C-reactive protein level, blood pressure, non–high-density lipoprotein cholesterol level, and glycemia. <h3>Results</h3> Among 10 308 participants, the mean (SD) age was 40.2 (0.3) years, and a mean (SD) of 50.5% (0.5%) were male. Overall, 56.2% of calories consumed were from the major subsidized food commodities. United States adults in the highest quartile of the subsidy score (compared with the lowest) had increased probabilities of having a body mass index of at least 30 (prevalence ratio, 1.37; 95% CI, 1.23-1.52), a ratio of waist circumference to height of at least 0.60 (prevalence ratio, 1.41; 95% CI, 1.25-1.59), a C-reactive protein level of at least 0.32 mg/dL (prevalence ratio, 1.34; 95% CI, 1.19-1.51), an elevated non–high-density lipoprotein cholesterol level (prevalence ratio, 1.14; 95% CI, 1.05-1.25), and dysglycemia (prevalence ratio, 1.21; 95% CI, 1.04-1.40). There was no statistically significant association between the subsidy score and blood pressure. <h3>Conclusions and Relevance</h3> Among US adults, higher consumption of calories from subsidized food commodities was associated with a greater probability of some cardiometabolic risks. Better alignment of agricultural and nutritional policies may potentially improve population health.
Detection and Quantification of Differentially Culturable Tubercle Bacteria in Sputum from Patients with Tuberculosis
Authors: Melissa D. Chengalroyen, Germar M. Beukes, Bhavna G. Gordhan, Elizabeth M. Streicher, Gavin Churchyard, Richard Hafner, Robin Warren, Kennedy Otwombe, Neil Martinson, Bavesh D. Kana
Journal: American Journal of Respiratory and Critical Care Medicine (2016)

Recent studies suggest that baseline tuberculous sputum comprises a mixture of routinely culturable and differentially culturable tubercle bacteria (DCTB). The latter seems to be drug tolerant and dependent on resuscitation-promoting factors (Rpfs).To further explore this, we assessed sputum from patients with tuberculosis for DCTB and studied the impact of exogenous culture filtrate (CF) supplementation ex vivo.Sputum samples from adults with tuberculosis and HIV-1 and adults with no HIV-1 were used for most probable number (MPN) assays supplemented with CF and Rpf-deficient CF, to detect CF-dependent and Rpf-independent DCTB, respectively.In 110 individuals, 19.1% harbored CF-dependent DCTB and no Rpf-independent DCTB. Furthermore, 11.8% yielded Rpf-independent DCTB with no CF-dependent DCTB. In addition, 53.6% displayed both CF-dependent and Rpf-independent DCTB, 1.8% carried CF-independent DCTB, and 13.6% had no DCTB. Sputum from individuals without HIV-1 yielded higher CF-supplemented MPN counts compared with counterparts with HIV-1. Furthermore, individuals with HIV-1 with CD4 counts greater than 200 cells/mm3 displayed higher CF-supplemented MPN counts compared with participants with HIV-1 with CD4 counts less than 200 cells/mm3. CF supplementation allowed for detection of mycobacteria in 34 patients with no culturable bacteria on solid media. Additionally, the use of CF enhanced detection of sputum smear-negative individuals.These observations demonstrate a novel Rpf-independent DCTB population in sputum and reveal that reduced host immunity is associated with lower prevalence of CF-responsive bacteria. Quantification of DCTB in standard TB diagnosis would be beneficial because these organisms provide a putative biomarker to monitor treatment response and risk of disease recurrence.
T1 Mapping in Characterizing Myocardial Disease
Authors: Valentina O. Puntmann, Elif Peker, Y. Chandrashekhar, Eike Nagel
Journal: Circulation Research (2016)

Cardiovascular magnetic resonance provides insights into myocardial structure and function noninvasively, with high diagnostic accuracy and without ionizing radiation. Myocardial tissue characterization in particular gives cardiovascular magnetic resonance a prime role among all the noninvasive cardiovascular investigations. Late gadolinium enhancement imaging is an established method for visualizing replacement scar, providing diagnostic and prognostic information in a variety of cardiac conditions. Late gadolinium enhancement, however, relies on the regional segregation of tissue characteristics to generate the imaging contrast. Thus, myocardial pathology that is diffuse in nature and affecting the myocardium in a rather uniform and global distribution is not well visualized with late gadolinium enhancement. Examples include diffuse myocardial inflammation, fibrosis, hypertrophy, and infiltration. T1 mapping is a novel technique allowing to diagnose these diffuse conditions by measurement of T1 values, which directly correspond to variation in intrinsic myocardial tissue properties. In addition to providing clinically meaningful indices, T1-mapping measurements also allow for an estimation of extracellular space by calculation of extracellular volume fraction. Multiple lines of evidence suggest a central role for T1 mapping in detection of diffuse myocardial disease in early disease stages and complements late gadolinium enhancement in visualization of the regional changes in common advanced myocardial disease. As a quantifiable measure, it may allow grading of disease activity, monitoring progress, and guiding treatment, potentially as a fast contrast-free clinical application. We present an overview of clinically relevant technical aspects of acquisition and processing, and the current state of art and evidence, supporting its clinical use.
THE SEROTHERAPY OF BACILLARY DYSENTERY IN CHILDREN
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal