tbuckley/cabot-search huggingface dataset:
The Incidence of Primary Carcinoma of the Liver in the Southern Bantu. I. Critical Review of the Literature
Authors: A. G. Oettlé
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article The Incidence of Primary Carcinoma of the Liver in the Southern Bantu. I. Critical Review of the Literature Get access A. G. Oettlé A. G. Oettlé South African Institute for Medical Research, Johannesburg, Transvaal, South Africa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 3, September 1956, Pages 249–280, https://doi.org/10.1093/jnci/17.3.249 Published: 01 September 1956 Article history Received: 17 May 1956 Published: 01 September 1956
Pragmatic Clinical Trials in CKD: Opportunities and Challenges
Authors: Ian H. de Boer, Csaba P. Kovesdy, Sankar D. Navaneethan, Carmen A. Peralta, Delphine S. Tuot, Miguel A. Vazquez, Deidra C. Crews
Journal: Journal of the American Society of Nephrology (2016)

Randomized controlled trials in CKD lag in number behind those of other chronic diseases, despite the high morbidity and mortality experienced by patients with kidney disease and the exorbitant costs of their health care. Observational studies of CKD frequently yield seemingly paradoxic associations of traditional risk factors with outcomes, making it difficult to extrapolate the results of trials conducted in people with normal kidney function to patients with CKD. However, many completed trials in CKD have been limited by intermediate outcomes of unclear clinical significance or narrow eligibility criteria that limit external validity, and implementation of proven therapies remains a challenge. It is therefore imperative that the nephrology community capitalize on recent interest in novel approaches to trial design, such as pragmatic clinical trials. These trials are meant to promote research within real world settings to yield clinically relevant results with greater applicability than those of traditional trials, while maintaining many advantages, such as controlling for potential sources of bias. We provide a description of pragmatic clinical trials and a discussion of advantages, disadvantages, and practical challenges inherent to this study design, in the context of specific scientific questions relevant to patients with CKD.
An outbreak of Salmonella enteritidis food poisoning from a commercially produced cheese
Authors: M. G. Panico, F Primiano, F Nappi, F Attena
Journal: Eurosurveillance (1999)

Nine suspected cases of food poisoning were reported from three hospitals to the epidemiology and prevention service (Servizio di Epidemiologia e Prevenzione - SEP) of the local health authority in Naples district (Azienda Sanitaria Locale, ASL NA 4) betw
FURTHER REFINEMENT OF LIVER EXTRACTS EFFECTIVE IN PERNICIOUS ANEMIA
Authors: P. W. C.
Journal: Annals of Internal Medicine (1948)

Editorial1 December 1948FURTHER REFINEMENT OF LIVER EXTRACTS EFFECTIVE IN PERNICIOUS ANEMIAP. W. C.P. W. C.Search for more papers by this authorAuthor, Article and Disclosure Informationhttps://doi.org/10.7326/0003-4819-29-6-1169 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe production of liver extracts which could be administered parenterally to patients with pernicious anemia constituted an important advance in the treatment of this disease. The earlier types of extracts were crude mixtures in which the active substance was present in relatively high dilution. Although the intensive work carried on during the past 15 years has resulted in the production of extracts for therapeutic use of far higher concentration, attempts to isolate the active substance and determine its chemical nature have hitherto been unsuccessful. Such work has been greatly hampered by the lack of any chemical or biological test to...1 SHORB MS : Unidentified growth factors for Lactobacillus lactis in refined liver extracts, Jr. Biol. Chem., 1947, clxix, 455-456. CrossrefGoogle Scholar2 RICKES EL : Crystalline vitamin B12 , Science, 1948, cvii, 396-397. CrossrefGoogle Scholar3 SHORB MS : Activity of vitamin B12 for the growth of Lactobacillus lactis , Science, 1948, cvii, 397-398. CrossrefGoogle Scholar4 WEST R : Activity of vitamin B12 in Addisonian pernicious anemia, Science, 1948, cvii, 398. CrossrefGoogle Scholar5 SPIES TD : Observations on the antianemic properties of vitamin B12 , South. Med. Jr., 1948, xli, 522-523. CrossrefGoogle Scholar6 SPIES TD : Observations on the hemopoietic response of persons with tropical sprue to vitamin B12 , South. Med. Jr., 1948, xli, 523-525. CrossrefGoogle Scholar7 SPIES TD and SUAREZ RM : Response of tropical sprue to vitamin B12 , Blood, 1948, iii, 1213-1220. CrossrefGoogle Scholar8 ROSS JF : The development and progression of subacute combined degeneration of the spinal cord in patients with pernicious anemia treated with synthetic pteroylglutamic (folic) acid, Blood, 1948, iii, 68-90. CrossrefGoogle Scholar9 SPIES TD : The association between gastric achlorhydria and subacute combined degeneration of the spinal cord, Postgrad. Med., 1948, iv, 89-95. CrossrefGoogle Scholar10 BERK L : Effectiveness of vitamin B12 in combined system disease, New England Jr. Med., 1948, ccxxxix, 328-330. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1948Volume 29, Issue 6Page: 1169-1172 Issue Published: 1 December 1948 Loading ...
Administrative relationships between community mental health centers and academic psychiatry departments
Authors: L R Faulkner, J S Eaton
Journal: American Journal of Psychiatry (1979)

The authors reviewed the administrative relationships between academic departments of psychiatry and community mental health centers (CMHCs). By telephone, they surveyed the chairpersons of 110 departments of psychiatry with approved psychiatric residency programs and found that 87 (79%) had some type of administrative relationship with a comprehensive CMHC. Almost two-thirds of the chairpersons of these departments considered the CMHC to be of major importance to their educational programs. Only 8 (7%) of the 110 departments had discontinued their relationship with a CMHC. Most of the chairpersons whose departments were involved with a center were optimistic about the future of their programs in CMHCs.
AB0694 Resolution of Generalized Deep Variant Morphea (Morphea Profunda): A Case Series of Three Patients Successfully Treated with Abatacept
Authors: F. Adeeb, S. Anjum, O. Hussein, W.L. Ng, M. Brady, S. Morrissey, J. Devlin, A.D. Fraser
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Deep Variant Morphea (DMV), previously known as morphea profunda, is an exceptionally rare form of sclerosis that is confined to the skin, and unlike scleroderma, has no systemic or internal organ involvement. The inflammation and sclerosis involves layers of the deep dermis, panniculus, fascia or even the underlying superficial muscle. An initial inflammatory phase, which can be extremely painful, is followed by skin sclerosis, which may cause joint contractures. It is a progressive and highly destructive disease, with apparently no effective treatment, leaving patients with hard, rock-like skin, and ultimately in the worst cases, early death. <h3>Objectives</h3> To evaluate the treatment impact and efficacy of Abatacept (Orencia) in patients presented with Deep Variant Morphea. <h3>Methods</h3> Three patients with established deep variant morphea and no contraindications to Abatacept were included in this prospective, open label study. Skin biopsies were performed to confirm deposition of dense fibrous tissue in the appropriate layer of the skin. Baseline Modified Rodnan Score were performed independently by 3 clinicians. VAS scores (10cm) were measured at baseline for Patient Global Disease Activity (PGDA), Patient Global Pain (PGP), Patient Day Pain (PDP), Patient Night Pain (PNP), Physician Global Disease Activity (PhGDA). Further investigations include High Resolution Ultrasound (HRUS) at 10 sites as well as whole body MRI.Patients were commenced on Abatacept (Orencia) as per body weight (10mg/kg), intravenously with tapering dose of oral prednisolone. All outcome measures including imaging were repeated 6-months after commencement of therapy to monitor disease progression. <h3>Results</h3> All patients tolerated the Abatacept well and showed dramatic improvement including their Baseline Rodnan Score, VAS outcome measures and imaging. All of them continued to be in complete clinical remission. <h3>Conclusions</h3> Deep variant morphea are difficult to treat. Therefore, timely diagnosis of the condition is crucial, as treatment should be aimed during the early inflammatory phase. The three cases further offer support for the use of Abatacept in cases of acute deep variant morphea, a dreadful, disfiguring and life-threatening disease with apparently no effective treatment until now. <h3>References</h3> Zwischenberger BA, Jacobe HT. A systematic review of morphea treatments and therapeutic algorithm. J Am Acad Dermatol 2011: 65: 925–941. Fett N, Werth VP. Update on morphea: part II. Outcome measures and treatment. J Am Acad Dermatol 2011: 64: 231–242; quiz 43–44. B. Stausbol-Gron et al. Abatacept is a Promising Treatment for Patients with Disseminated Morphea Profunda: Presentation of Two Cases. Acta Derm Venereol 2011; 91: 686-688. <h3>Disclosure of Interest</h3> None declared
Response to commentary on endometrial cancer deaths in tamoxifen-treated breast cancer patients.
Authors: J S Patterson, P V Plourde, A Milbauer
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.10.2886 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8874352 Response to commentary on endometrial cancer deaths in tamoxifen-treated breast cancer patients. J S PattersonxJ S PattersonSearch for articles by this author , P V PlourdexP V PlourdeSearch for articles by this author , A MilbauerxA MilbauerSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.10.2886 PDF "Response to commentary on endometrial cancer deaths in tamoxifen-treated breast cancer patients.." Journal of Clinical Oncology, 14(10), pp. 2886–2887© 1996 by American Society of Clinical Oncology
AB0408 Are Atypical Femoral Fractures in Rheumatic Patients Increasing?
Authors: Y. Takakubo, S. Okuda, Y. Naganuma, R. Ooishi, H. Oki, Y. Tamaki, A. Sasaki, A. Narita, T. Hirayama, Y. Tamaki, K. Sasaki, M. Takagi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Atypical femoral fractures with low-energy or lack of trauma have been reported to relate using of the bisphosphonates (BPs) and glucocorticoids for a long time, affecting collagen diseases<sup>1,2</sup>. <h3>Objectives</h3> The aim of this study was to analyze the atypical femoral fractures in rheumatic patients in our four institutes retrospectively. <h3>Methods</h3> We investigated the cases of atypical femoral fractures summarized by the American Society for Bone and Mineral Research (ASBMR) Task Force 2010<sup>1</sup> among our out-rheumatic patients from 2009 to 2014. <h3>Results</h3> We have 1,091 out-rheumatic patients/year in our four institutes from 2009 to 2014. The patients with atypical femoral fractures were 8 limbs in six women (0.12%) in six years. Three limbs were injured at 2013, and five at 2014, including two cases has both side atypical femoral fractures (Fig. 1). The mean age of them was 51 year-old (38-73). As comorbid conditions, two patients has dermatomyositis, systematic lupus erythematosus, one rheumatoid arthritis and one polyarteritis nodosa. Fracture types were seven subtrochanteric fractures and one diaphyseal femoral fracture. All patients received BPs and prednisolone (PSL). Mean duration of receiving the drugs was 75 months (36-120) and 114 months (60-180), respectively. Mean dosage of PSL was 15 mg/day (5-30). After affecting the fractures, BPs were quitted and the surgery using intramedullary nail fixation were performed in all cases. One case had the surgical-site infection. Teriparatide was induced excepted one case and therapy of low-intensity pulsed ultrasound was started for all cases after healing their operated wounds. Mean duration of post-operative observation was 12 months (5-23). At the latest follow-up, five femurs were observed the sign of union at fracture site on X-ray or computed tomography of their femurs, but not other three femurs. Mean duration of union of the fracture site was 10 months (6-13) in five femurs. <h3>Conclusions</h3> Eight atypical femoral fractures were observed in 2013-14, but not in 2009-2012. Atypical femoral fracture may increase year by year. The careful management and treatment for the atypical femoral fractures in rheumatic patients were required even after the surgery, because our all cases have been observed the delayed union or non-union of fracture site at their latest follow-up<sup>3</sup>. <h3>References</h3> Shane E, et al. JMBR, 2010. Blacks DM, et al. NEJM, 2010. Thompson RN, et al. JBJS 2012. <h3>Disclosure of Interest</h3> None declared
Probiotics and Iletis
Authors: Christian Jobin
Journal: Gut Microbes (2010)

Probiotics have gained tremendous popularity amongst individuals searching for alternative and "natural" means to promote intestinal health. It has been suggested that the probiotic formulation VSL#3 promotes several aspects of intestinal health including attenuation of inflammatory bowel diseases (IBD). Although a definitive mechanism of action has not been clearly identified, it is generally accepted that probiotics suppress development of chronic inflammation by inhibiting activation of various inflammatory signaling pathways. This concept however needs to be revisited in light of a recent publication by Pagnini et al. showing that VSL#3 prevents development of ileitis through activation of NF-kB and production of the prototypical inflammatory cytokine TNFa.
Consequences of acute nitric oxide synthesis inhibition in experimental glomerulonephritis.
Authors: R Ferrario, K Takahashi, A Fogo, K F Badr, K A Munger
Journal: Journal of the American Society of Nephrology (1994)

To assess the functional relevance of the enhanced glomerular nitric oxide (NO) synthesis during acute nephrotoxic serum (NTS) nephritis, a NO synthesis inhibitor (NOI) NG-monomethyl-L-arginine was administered to normal (N + NOI) and acutely nephritic (NTS + NOI) Munich-Wistar rats, and systemic and glomerular hemodynamic responses were contrasted with those observed in vehicle-treated normal and nephritic (NTS) controls. Urinary protein excretion rates were equal in normal and N + NOI rats but were markedly elevated in NTS animals and further increased in NTS+NOI. NO inhibition in normal animals (normal versus N + NOI) led to reductions in glomerular plasma flow rate and the glomerular capillary ultrafiltration coefficient (Kf) and elevations in afferent and efferent arteriolar resistances and net transcapillary hydraulic pressure difference (delta P), as well as an increase in systemic arterial pressure. The increase in delta P offset the falls in glomerular plasma flow rate and Kf, and GFR was preserved. Directionally similar responses in efferent resistance occurred in NTS + NOI compared with NTS, however, afferent resistance was not further affected by NOI. Additionally, although Kf was severely depressed in the NTS group (approximately 60% versus normal), it was not further depressed by NOI treatment. Polymorphonuclear cell (PMN) infiltration/glomerulus was mildly increased in N + NOI over normal. In contrast, PMN number in NTS + NOI rats was diminished as compared with NTS.(ABSTRACT TRUNCATED AT 250 WORDS)
Organ Changes in Rats Exposed Repeatedly to Lowered Oxygen Tension with Reduced Barometric Pressure
Authors: Albert J. Dalton, Benjamin F. Jones, Virginia B. Peters, Ellis R. Mitchell
Journal: JNCI Journal of the National Cancer Institute (1945)

Journal Article Organ Changes in Rats Exposed Repeatedly to Lowered Oxygen Tension with Reduced Barometric Pressure Get access Albert J. Dalton, Albert J. Dalton senior cytologist National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Benjamin F. Jones, Benjamin F. Jones formerly surgeon National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia B. Peters, Virginia B. Peters junior cytologist National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar Ellis R. Mitchell Ellis R. Mitchell assistant chemist National Cancer Institute and Industrial Research Laboratory, National Institute of Health, United States Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 6, Issue 3, December 1945, Pages 161–185, https://doi.org/10.1093/jnci/6.3.161 Published: 01 December 1945
Abstract 164: β-adrenergic Stimulation Exacerbates Preclinical Arrhythmogenic Right Ventricular Cardiomyopathy Due To Desmoplakin Mutation
Authors: Subat Turdi, Nan Gong, Jeanne James, Patrick Winters, Lori Stanton, Enkhsaikhan Purevjav, Jeffrey A Towbin
Journal: Circulation Research (2014)

Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is associated with ventricular arrhythmias and sudden cardiac death. We previously demonstrated that cardiac-specific overexpression of human mutant desmoplakin (DSPR2834H) leads to ARVC in mice at 6 months of age. However, the potential role and mechanism(s) of DSP in preclinical ARVC under cardiac stress remains unclear. Objectives: This study is aimed to elucidate the impact of DSP in the development of ARVC under adrenergic stimulation. Methods: Three-month-old non-transgenic (NTg), wild-type DSP (Tg-DSPWT) and Tg-DSPR2834H mice without obvious signs of ARVC, including right and left ventricular dysfunction, arrhythmias, were infused with either vehicle or isoproterenol (30mg/kg/d) for 2 weeks using mini-osmotic pumps. During isoproterenol infusion, electrocardiography (ECG) was monitored daily on conscious mice. Echocardiography and cardiac MRI were performed before and after 2-week of isoproterenol infusion. Myocardial tissues from both RV and LV were subjected to cellular, biochemical and histopathological analysis. Results: Isoproterenol resulted in cardiac hypertrophy to a similar degree amongst all genotypes; however, mortality occurred only in Tg-DSPR2834H mice. Vehicle-treated mice from all genotypes showed largely normal ECGs, whereas isoproterenol led to various types of arrhythmia in Tg-DSPR2834H mice including ventricular tachycardia and QT prolongation. Echocardiography analysis revealed LV dysfunction (decreased factional shortening) in isoproterenol-treated Tg-DSPR2834H mice compared to other treatment groups. Interstitial fibrosis and lipid infiltration was prominent in the Tg-DSPR2834H myocardium. MRI analysis is being performed to understand the RV and LV geometry and function. Conclusion: Our preliminary data confirms the essential role of desmoplakin in response to adrenergic stimulation. Studies investigating the electrophysiological, geometrical and cellular mechanisms of the pro-arrhythmic nature of DSPR2834H dysfunction are ongoing which may ultimately provide critical experimental data on prevention of asymptomatic preclinical ARVC in humans.
Re-emergence of animal rabies in northern Greece and subsequent human exposure, October 2012 – March 2013
Authors: S Tsiodras, G Dougas, A Baka, C Billinis, S Doudounakis, A Balaska, T Georgakopoulou, G Rigakos, V Kontos, K E Tasioudi, M Tzani, P Tsarouxa, P Iliadou, O Mangana-Vougiouka, D Iliopoulos, S Sapounas, P Efstathiou, A Tsakris, C Hadjichristodoulou, J Kremastinou
Journal: Eurosurveillance (2013)

Greece has been rabies-free since 1987 with no human cases since 1970. During 2012 to 2013, rabies has re-emerged in wild and domestic animals in northern Greece. By end March 2013, rabies was diagnosed in 17 animals including 14 red foxes, two shepherd dogs and one cat; 104 subsequent human exposures required post-exposure prophylaxis according to the World Health Organization criteria. Human exposures occurred within 50 km radius of a confirmed rabies case in a wild or domestic animal, and most frequently stray dogs were involved.
Public health response to an outbreak of Legionnaires’ disease in Edinburgh, United Kingdom, June 2012
Authors: D McCormick, S Thorn, D Milne, C Evans, J Stevenson, M Llano, M Donaghy, Collective on behalf of the Incident Management Team
Journal: Eurosurveillance (2012)

Binary file ES_Abstracts_Final_ECDC.txt matches
Disability-Specific Atlases of Gray Matter Loss in Relapsing-Remitting Multiple Sclerosis
Authors: Allan MacKenzie-Graham, Florian Kurth, Yuichiro Itoh, He-Jing Wang, Michael J. Montag, Robert Elashoff, Rhonda R. Voskuhl
Journal: JAMA Neurology (2016)

Multiple sclerosis (MS) is characterized by progressive gray matter (GM) atrophy that strongly correlates with clinical disability. However, whether localized GM atrophy correlates with specific disabilities in patients with MS remains unknown.To understand the association between localized GM atrophy and clinical disability in a biology-driven analysis of MS.In this cross-sectional study, magnetic resonance images were acquired from 133 women with relapsing-remitting MS and analyzed using voxel-based morphometry and volumetry. A regression analysis was used to determine whether voxelwise GM atrophy was associated with specific clinical deficits. Data were collected from June 28, 2007, to January 9, 2014.Voxelwise correlation of GM change with clinical outcome measures (Expanded Disability Status Scale and Multiple Sclerosis Functional Composite scores).Among the 133 female patients (mean [SD] age, 37.4 [7.5] years), worse performance on the Multiple Sclerosis Functional Composite correlated with voxelwise GM volume loss in the middle cingulate cortex (P < .001) and a cluster in the precentral gyrus bilaterally (P = .004). In addition, worse performance on the Paced Auditory Serial Addition Test correlated with volume loss in the auditory and premotor cortices (P < .001), whereas worse performance on the 9-Hole Peg Test correlated with GM volume loss in Brodmann area 44 (Broca area; P = .02). Finally, voxelwise GM loss in the right paracentral lobulus correlated with bowel and bladder disability (P = .03). Thus, deficits in specific clinical test results were directly associated with localized GM loss in clinically eloquent locations.These biology-driven data indicate that specific disabilities in MS are associated with voxelwise GM loss in distinct locations. This approach may be used to develop disability-specific biomarkers for use in future clinical trials of neuroprotective treatments in MS.
Experimental Studies in Metal Can-cerigenesis. VII. Tissue Reactions to Parenterally Introduced Powdered Metallic Chromium and Chromite Ore
Authors: W. C. Hueper
Journal: JNCI Journal of the National Cancer Institute (1955)

Journal Article Experimental Studies in Metal Can-cerigenesis. VII. Tissue Reactions to Parenterally Introduced Powdered Metallic Chromium and Chromite Ore Get access W. C. Hueper W. C. Hueper National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 2, October 1955, Pages 447–469, https://doi.org/10.1093/jnci/16.2.447 Published: 01 October 1955 Article history Received: 14 February 1955 Published: 01 October 1955