tbuckley/cabot-search huggingface dataset:
AB1457-HPR “I feel sad when they don’t understand that it hurts so much.”
Authors: I. Ahlstrand, M. Björk, I. Thyberg, B. Börsbo, T. Falkmer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Despite early interventions, pain intensity is still moderate to high in the majority in rheumatoid arthritis (RA), leading to activity limitations and participation restrictions. The International Classification of Functioning, Disability and Health (ICF) is an overall conceptual model where disability and functioning are viewed as outcomes of interactions between health conditions and contextual factors. Activity is defined in ICF as the execution of a task or an action by an individual. Participation is defined as the involvement in a life situation. Environmental aspects, such as others’ attitudes, play a significant role for activity and participation. <h3>Objectives</h3> The aim of this study was to describe others’ attitudes of pain and its consequences for participation in everyday life for people with rheumatoid arthritis (RA). <h3>Methods</h3> Seven semi-structured focus group discussions were conducted with 33 men and women of different ages with RA. The discussions focused on environmental factors such as others’ attitudes of pain, understanding and social support, that facilitate or hinder daily activities and participation in social contexts. Data were analysed with content analysis. <h3>Results</h3> Regarding the impact of pain on participation and independence, personal factors and the social environment were found to be important. The participants were frustrated with not being able to do what they wanted or needed to do, reduced opportunities for participation in the social context and being dependent on family and friends for everyday functioning. Attitudes of employers, colleagues, friends and relatives were perceived to affect the consequences of pain in everyday activities, both positively and negatively. Support from family and friends created opportunities for participation. Other people’s thoughtfulness contributed to well-being at times with severe pain. Colleagues’ support was perceived as important. Lack of support from colleagues, family and friends were causing participation restrictions. Poor understanding of the pain or friends ignoring the pain obstructed participation in social contexts. Participants described having to ask for help or to hand over activities at home, which created a feeling of dependence. This was perceived as annoying and inconvenient. <h3>Conclusions</h3> The relationship between pain and daily activities in RA was complex. Pain as an impairment was expressed to be related to activity limitations and participation restrictions, as well as to contextual factors. These findings highlight the clinical importance of paying attention to the complexity of pain and its relation to daily activities and participation. <h3>Disclosure of Interest</h3> None Declared
Risk of Cancer in Patients with Dermatomyositis or Polymyositis
Authors: Bárdur Sigurgeirsson, Bernt Lindelöf, Olof Edhag, Erik Allander
Journal: New England Journal of Medicine (1992)

An association between polymyositis and cancer was first proposed in 1916, but the existence of the association has been disputed. An association between dermatomyositis and cancer is better accepted, but its magnitude is not known.We undertook a study to provide accurate estimates of the risk of cancer in patients with dermatomyositis or polymyositis. We studied the incidence of cancer and the rate of mortality from cancer in a population-based cohort of 788 patients with dermatomyositis or polymyositis in Sweden from 1963 through 1983. The results were compared with those for the general population.Among the 396 patients with polymyositis, 42 cancers were diagnosed at the same time or after polymyositis was diagnosed in 37 patients (9 percent). The relative risk of cancer was 1.8 (95 percent confidence interval, 1.1 to 2.7) in the male patients and 1.7 (95 percent confidence interval, 1.0 to 2.5) in the female patients. Eighty-four males and 85 females died, and in 24 of these cases (14 percent) cancer was the principal cause of death. The mortality ratio (the rate of mortality from cancer in these patients as compared with that in the general population) was 0.90 (95 percent confidence interval, 0.6 to 1.4). Among the 392 patients with dermatomyositis, 61 cancers were diagnosed at the same time or after dermatomyositis was diagnosed in 59 patients (15 percent). The relative risk of cancer was 2.4 (95 percent confidence interval, 1.6 to 3.6) in the male patients and 3.4 (95 percent confidence interval, 2.4 to 4.7) in the female patients. Fifty-seven males and 110 females died, and in 67 of these cases (40 percent) cancer was the principal cause of death (mortality ratio, 3.8; 95 percent confidence interval, 2.9 to 4.8).The risk of cancer is increased in patients with polymyositis or dermatomyositis. In patients with dermatomyositis there is also a higher rate of mortality from cancer.
OP0054 Complete freund’s adjuvant induces, in interferon-gamma-deficient mice, a chronic inflammatory disease reminiscent of systemic juvenile idiopathic arthritis
Authors: A. Avau, T. Mitera, K. Put, S. Put, T. Tousseyn, A.D. Billiau, C. Wouters, P. Matthys
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Stroke after acute coronary syndrome (ACS) can be devastating. It is uncertain whether the risks of ischaemic stroke or intracranial haemorrhage (ICH) are associated with different choices of P2Y12 inhibitors (potent P2Y12 inhibitors such as ticagrelor and prasugrel vs clopidogrel). Even though East Asians are known to have different thrombotic and haemorrhagic profiles from Caucasians, data on Chinese patients are sparse. <h3>Method</h3> This was a retrospective cohort study conducting in Chinese patients with ACS who underwent first-ever percutaneous coronary intervention from 14 hospitals in Hong Kong between 2010 and 2017. The primary efficacy endpoint was ischaemic stroke. The secondary efficacy endpoint was a composite outcome of thrombotic events including all-cause mortality, non-fatal myocardial infarction and ischaemic stroke. The primary safety endpoint was ICH. The secondary safety endpoint was a composite of major bleeding events. <h3>Results</h3> After adjustment of baseline characteristics by 1:1 propensity score matching, a total of 6220 patients (3110 on each group) were analysed. Compared with clopidogrel, potent P2Y12 inhibitors were associated with a lower risk of ischaemic stroke (HR 0.57; 95% CI 0.37 to 0.87; p=0.008) and a lower risk of thrombotic events (HR 0.77; 95% CI 0.66 to 0.90; p=0.001). Potent P2Y12 inhibitor was associated with similar risk of ICH (HR 0.65; 95% CI 0.34 to 1.25, p=0.20) and major bleeding (HR 0.83; 95% CI 0.68 to 1.01, p=0.069). <h3>Conclusions</h3> Potent P2Y12 inhibitors were associated with a lower adjusted risk of ischaemic stroke and thrombotic events, compared with clopidogrel. The risks of ICH and major bleeding were similar.
RATIO OF SYSTOLIC BLOOD PRESSURE TO LEFT VENTRICULAR END-DIASTOLIC PRESSURE AT THE TIME OF PERCUTANEOUS CORONARY INTERVENTION PREDICTS IN-HOSPITAL MORTALITY IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION
Authors: Michael Sola, Robert Rayson, Kiran Venkatesh, Melissa Caughey, Xuming Dai, George Stouffer, Michael Yeung
Journal: Journal of the American College of Cardiology (2016)
Prevalence of Sensitisation to Food and Aero-Allergens and Challenge Proven Food Allergy Amongst 11-Year-Old Children on the Isle of Wight
Authors: Carina Venter, Veeresh Patil, Jane Grundy, Gill Glasbey, Syed H. Arshad, Taraneh Dean
Journal: Journal of Allergy and Clinical Immunology (2015)
Complications in gastrointestinal endoscopy: a summary at the first international symposium in Hannover 2009
Authors: P. Meier
Journal: Endoscopy (2011)

Following the recent success of the Second International Symposium on Complications in Gastrointestinal Endoscopy (17-18 June 2011, Hannover, Germany), it would be worth reminding ourselves of the key points and highlights of the first symposium held in Hannover in June 2009. The congress, which is endorsed by the American Society for Gastrointestinal Endoscopy (ASGE) under the patronage of the European Society for Gastrointestinal Endoscopy (ESGE), is designed to bring together endoscopists and support staff to present and discuss the diagnosis, treatment, and prevention of complications associated with gastrointestinal endoscopy, including effective communication strategies and management in particular patient groups. This current report is a brief summary of topics discussed at the inaugural symposium in 2009.
Successful Treatment of a Patient with a Thymoma and Pure Red-Cell Aplasia with Octreotide and Prednisone
Authors: Giovannella Palmieri, Secondo Lastoria, Annamaria Colao, Emilia Vergara, Paola Varrella, Edoardo Biondi, Carmine Selleri, Lucio Catalano, Gaetano Lombardi, Angelo Raffaele Bianco, Marco Salvatore
Journal: New England Journal of Medicine (1997)

Thymomas are rare epithelial neoplasms frequently associated with myasthenia gravis, hypogammaglobulinemia, and pure red-cell aplasia.1–11 In pure red-cell aplasia, autoantibodies against early and late erythroid-cell progenitors or erythropoietin, as well as inhibitory cellular immune mechanisms, have been implicated.9–11 Limited information suggests that patients with pure red-cell aplasia and thymoma have a poor prognosis.6,7,10 We recently demonstrated a high uptake of indium-labeled octreotide (111In-DTPA-d-Phe1-octreotide) in thymomas, a phenomenon related to the high content of somatostatin receptors in these tumors.12 The same labeling method has been successful in imaging a wide variety of neuroendocrine tumors.13, . . .
Abstract P6-04-10: Comprehensive gene and protein assessment of the role of Her2 in the response to neoadjuvant Letrozole suggests patients without amplification may also benefit from anti-Her2 treatment
Authors: V Webber, AK Turnbull, AA Larionov, AH Sims, D Harrison, L Renshaw, JM Dixon
Journal: Cancer Research (2012)

Abstract Background: Older postmenopausal patients with large operable or locally advanced oestrogen receptor positive, invasive breast cancers are candidates for treatment with neoadjuvant letrozole. HER2 positivity is a potential marker for early endocrine therapy resistance. In this study we have evaluated the effects of HER2 amplification, gene and protein expression at diagnosis and following 14 and 90 days of treatment with neoadjuvant Letrozole. Methods: 70 postmenopausal women with large operable and locally advanced oestrogen receptor (ER) positive invasive breast cancers were treated with neoadjuvant letrozole. Response was assessed by 3D ultrasound. Sequential core biopsies were taken at 0, 14 days and 3 months of treatment. 12 patients were HER2 positive (either 3+ or 2+ FISH positive), 20 were HER2 2+ FISH negative and 38 were HER2 negative (0 or +). Results: 43 patients were responders to letrozole and 17 were non-responders. 7 of the 17 non-responders were HER2 positive. Analysing response in two groups (HER2 2+ and 3+ together versus 0 or +) there was a greater difference in response rate between these two groups than when splitting into conventional HER2 positive and negative groups (P &amp;lt; 0.0001). In non-responding patients HER2 gene expression levels from the microarrays taken at baseline were significantly higher than the HER2 expression in responding patients (p = 0.01). There was also an increase in HER2 gene expression seen during the first 14 days of treatment in non-responding but not responding patients (p = 0.08). Rank product analysis of gene expression identified 34 down-regulated genes and 7 up-regulated genes which were shared between the HER2 2+ FISH negative samples and samples which were HER2 3+ or HER2 2+ FISH positive. Conclusion: This large cohort of patients treated with neoadjuvant letrozole shows that: HER2 expression correlates with response to letrozole. A better cut off for prediction of response to letrozole is the split between 0 and + versus 2+ and 3+ rather than the traditional 3+. Patients with increased MRNA expression at diagnosis for HER2 have a significantly lower response rate to neoadjuvant letrozole. Endocrine therapy together with anti-HER2 therapies should be considered for patients having neoadjuvant endocrine therapy for cancers which over express HER2. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P6-04-10.
OP0238 Hand joint ultrasound assessment shows more erosion in elderly onset recent rheumatoid arthritis (RA) patients compared to young onset recent RA:
Authors: W. Hamdi, M.M. Ghannouchi, M. Bouaziz, F.M. Ladeb, M.M. Kchir
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Joint ultrasound is a sensitive means to detect joint inflammation particularly in recent RA. Ultrasound findings in elderly onset RA patients have not been previously compared with sonographic signs in young onset RA patients. <h3>Objectives</h3> To compare sonographic scores of inflammation and erosion between patient with elderly onset and young onset patients with recent RA. <h3>Methods</h3> Cross sectional study of 88 consecutives patients with recent rheumatoid arthritis (&lt;24 months) diagnosed according to ACR 87 RA criterion. All patients were assessed by sonography of the wrists, metacarpo-phalangeal (MCP) and proximal inter-phalangeal joints (PIP) including semiquantitative scoring of synovial hypertrophy/effusion (SH/E), power Doppler (PD) signals and erosion. The ultrasound scores were calculated by the addition of corresponding ultrasound signs in both hands joints. Elderly onset RA was defined by a disease onset after the age of 60 years. Statistical analysis was performed by analysis of variance ANOVA. Significance was accepted for p&lt;0.05. <h3>Results</h3> Seventy two women and 16 men were included. Their mean age were 52.1±14 years [16-76]. Twenty four patients were diagnosed with elderly onset RA. Comparison of ultrasound scores were showed in table 1. Only erosion score was significantly higher in elderly onset RA than young onset RA patients. <h3>Conclusions</h3> This study shows that ultrasound detect more erosion in elderly onset recent RA compared with young onset RA but similar inflammation scores. <h3>Disclosure of Interest</h3> None Declared
Ivacaftor in a G551D Homozygote with Cystic Fibrosis
Authors: Michael J. Harrison, Desmond M. Murphy, Barry J. Plant
Journal: New England Journal of Medicine (2013)

Ivacaftor, an oral potentiator of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, has been shown to be efficacious in patients heterozygous for the G551D mutation in CFTR. This letter describes the effect of ivacaftor in a patient homozygous for this mutation.
Planned Out-of-Hospital Birth and Birth Outcomes
Authors: Jonathan M. Snowden, Ellen L. Tilden, Janice Snyder, Brian Quigley, Aaron B. Caughey, Yvonne W. Cheng
Journal: New England Journal of Medicine (2015)

The frequency of planned out-of-hospital birth in the United States has increased in recent years. The value of studies assessing the perinatal risks of planned out-of-hospital birth versus hospital birth has been limited by cases in which transfer to a hospital is required and a birth that was initially planned as an out-of-hospital birth is misclassified as a hospital birth.We performed a population-based, retrospective cohort study of all births that occurred in Oregon during 2012 and 2013 using data from newly revised Oregon birth certificates that allowed for the disaggregation of hospital births into the categories of planned in-hospital births and planned out-of-hospital births that took place in the hospital after a woman's intrapartum transfer to the hospital. We assessed perinatal morbidity and mortality, maternal morbidity, and obstetrical procedures according to the planned birth setting (out of hospital vs. hospital).Planned out-of-hospital birth was associated with a higher rate of perinatal death than was planned in-hospital birth (3.9 vs. 1.8 deaths per 1000 deliveries, P=0.003; odds ratio after adjustment for maternal characteristics and medical conditions, 2.43; 95% confidence interval [CI], 1.37 to 4.30; adjusted risk difference, 1.52 deaths per 1000 births; 95% CI, 0.51 to 2.54). The odds for neonatal seizure were higher and the odds for admission to a neonatal intensive care unit lower with planned out-of-hospital births than with planned in-hospital birth. Planned out-of-hospital birth was also strongly associated with unassisted vaginal delivery (93.8%, vs. 71.9% with planned in-hospital births; P<0.001) and with decreased odds for obstetrical procedures.Perinatal mortality was higher with planned out-of-hospital birth than with planned in-hospital birth, but the absolute risk of death was low in both settings. (Funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development.).
Breast Cancer Prevention Trial Will Resume
Authors: K. Smigel, S. Ulbrich
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Breast Cancer Prevention Trial Will Resume Get access Kara Smigel, Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar Santra Ulbrich Santra Ulbrich Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 13, 6 July 1994, Pages 961–963, https://doi.org/10.1093/jnci/86.13.961 Published: 06 July 1994
Right or Left, Right or Wrong? Debate Whirls Over Colorectal Cancer Distribution
Authors: D. Milne
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Right or Left, Right or Wrong? Debate Whirls Over Colorectal Cancer Distribution Get access David Milne David Milne Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 19, 5 October 1994, Pages 1442–1443, https://doi.org/10.1093/jnci/86.19.1442 Published: 05 October 1994
Increased Glomerular Filtration Rate in Kidney-Transplant Recipients Who Take Sildenafil
Authors: Lionel Rostaing, Tuan Tran-Van, Jean-Louis Ader
Journal: New England Journal of Medicine (2000)

To the Editor: Sildenafil is a potent inhibitor of guanosine 3',5'-cyclic monophosphate (cGMP)–specific phosphodiesterase.1,2 It is being used increasingly by male kidney-transplant recipients for ...
PWE-023 Could Faecal Immunochemical Tests for Haemoglobin (FIT) Change Surveillance of People with Intermediate Risk Adenomas?
Authors: I Kralj-Hans, J Martin, S Pearson, C Piggott, H Bowyer, G Vart, C von Wagner, J Wardle, S Halloran, W Atkin
Journal: Gut (2013)

<h3>SUMMARY:</h3> A health care crisis such as the coronavirus disease 2019 (COVID-19) pandemic requires allocation of hospital staff and resources on short notice. Thus, new and sometimes less experienced team members might join the team to fill in the gaps. This scenario can be particularly challenging in endovascular stroke treatment, which is a highly specialized task that requires seamless cooperation of numerous health care workers across various specialties and professions. This document is intended for stroke teams who face the challenge of integrating new team members into endovascular stroke-treatment workflows during the COVID-19 pandemic or any other global health care emergency. It discusses the key strategies for smooth integration of new stroke-team members in a crisis situation: 1) transfer of key knowledge (simple take-home messages), 2) open communication and a nonjudgmental atmosphere, 3) strategic task assignment, and 4) graded learning and responsibility. While these 4 key principles should generally be followed in endovascular stroke treatment, they become even more important during health care emergencies such as the COVID-19 pandemic, when health care professionals have to take on new and additional roles and responsibilities in challenging working environments for which they were not specifically trained.
DETERMINATION OF LEFT VENTRICULAR MASS IN MAN: CINE VERSUS GATED SPIN ECHO NMR IMAGING TECHNIQUES.
Authors: Enrique Ostrzega, John Crues, Hiroshi Honma, John Friedman, Yzhar Charuzi, Daniel Berman
Journal: Clinical Nuclear Medicine (1987)

Ostrzega, Enrique; Crues, John; Honma, Hiroshi; Friedman, John; Charuzi, Yzhar; Berman, Daniel Author Information
Abstract 4883: Zinc and prostate cancer: a systematic review.
Authors: Abeer M. Mahmoud, Umaima Al-alem, Ebony Shah, Ken Batai, Firas Dabbous, Mohamed Ali, Rick Kittles
Journal: Cancer Research (2013)

Abstract Background: Zinc is involved in many essential cellular functions. It has been shown that the prostate contains high concentrations of zinc, but zinc levels decrease in prostate cancer tissues. Although, experimental evidence implicates zinc in the pathogenesis of prostate cancer, epidemiological data are inconsistent. We conducted a systematic review of the literature to summarize the evidence regarding the association between zinc and prostate cancer. Methods: Relevant studies were identified by searching PubMed and the Cochrane Library databases through November 2012 and reviewing reference lists of retrieved articles. Inclusion criteria were original and peer-reviewed publications reporting the association between zinc intake or status and prostate cancer outcomes (diagnosis, progression). No reviews, editorials, or comments were included. Two investigators abstracted study information and evaluated quality independently using standardized forms. Results: Sixteen studies met inclusion criteria, including 3 cohorts, 2 nested case-control, 10 case-control, and 1 randomized clinical trial, with a total of 111,288 participants and 11,681 cases of prostate cancer. All studies measured the association between zinc levels and prostate cancer. In most studies, regardless of the study design or source of zinc, the highest dose of zinc was associated with a modest elevation of odds of prostate cancer. Four studies had decreased odds of prostate cancer for the highest dose of zinc but the confidence interval crossed one. There was evidence of a dose-response relationship and subgroup analysis revealed a protective effect of high zinc intake among advanced prostate cancer cases. Conclusions: Although the level of zinc in prostate cancer tissue is reduced, studies assessing the association of zinc intake and prostate cancer have yielded inconsistent results. We performed a systematic review to assess the role of zinc in prostate cancer. As a result of this systematic review, the evidence is still insufficient to recommend zinc supplementation for cancer patients in clinical practice. Citation Format: Abeer M. Mahmoud, Umaima Al-alem, Ebony Shah, Ken Batai, Firas Dabbous, Mohamed Ali, Rick Kittles. Zinc and prostate cancer: a systematic review. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4883. doi:10.1158/1538-7445.AM2013-4883
Tetanus-Toxoid Emergency Boosters
Authors: Thomas C. Peebles, Leo Levine, Mary C. Eldred, Geoffrey Edsall
Journal: New England Journal of Medicine (1969)

Measurement of tetanus antibody titers in 143 pediatric patients receiving routine and emergency immunization according to current practice showed that none who had received four or more injections failed to maintain the accepted protective level of 0.01 AU per milliliter for any measured interval. Analysis of the data indicated that the interval of protection after four or more injections is greater than 12 years from the last injection, with a confidence level of 99.9 per cent. When there is a valid history of the routine schedule of immunization outlined, special tetanus boosters on admission to camps, schools and colleges and emergency injections at times of injury should be abandoned, to minimize toxoid reactions. The risk of contracting tetanus if these recommendations are followed is calculated to be so remote as to approximate zero.