tbuckley/cabot-search huggingface dataset:
Prevalence of severe mental disorders in disaffiliated and homeless people in inner Melbourne
Authors: H Herrman, P McGorry, P Bennett, R van Riel, B Singh
Journal: American Journal of Psychiatry (1989)

The authors determined the prevalence of mental illness in 382 people representative of the occupants of shelters for the homeless and cheap single-room accommodations in inner-city areas of Melbourne. Clinicians were trained to use a standardized diagnostic instrument, the Structured Clinical Interview for DSM-III-R, to diagnose a range of severe mental disorders, including psychotic, affective, and substance-related disorders. Almost half the people interviewed received diagnoses of current disorders, and over 70% received lifetime diagnoses. There was considerable comorbidity. Many factors are likely to contribute to the concentration of people with mental disorders in such homeless and disaffiliated groups.
Participation in Cancer Pharmacogenomic Studies: A Study of 8456 Patients Registered to Clinical Trials in the Cancer and Leukemia Group B (Alliance)
Authors: Lynn G. Dressler, Allison M. Deal, Kouros Owzar, Dorothy Watson, Katherine Donahue, Paula N. Friedman, Mark J. Ratain, Howard L. McLeod
Journal: JNCI Journal of the National Cancer Institute (2015)

Clinically annotated specimens from cancer clinical trial participants offer an opportunity for discovery and validation of pharmacogenomic findings. The purpose of this observational study is to better understand patient/institution factors that may contribute to participation in the pharmacogenomic component of prospective cancer clinical trials. Patient demographic information (age, sex, self-reported race) and institutional characteristics (CALGB/CTSU site, "diversity," and accrual) were evaluated for 8456 patients enrolled in seven CALGB phase III studies with a pharmacogenomic component. All statistical tests were two-sided. The majority of patients (81%) consented to participate in the pharmacogenomic component. However, in a multivariable analysis, site (CALGB vs CTSU) and "institutional diversity" (percent minority cancer patients on national trials) were statistically significantly associated with participation. For both whites and nonwhites, patients from CALGB sites were more likely to participate compared with patients from CTSU sites (whites: odds ratio [OR] = 2.26, 95% confidence interval [CI] = 1.68 to 3.04, P < .001; nonwhites: OR = 1.79, 95% CI = 1.52 to 2.11, P < .001). However, as "institutional diversity" increased, the likelihood of participation in the pharmacogenomics component decreased for both white (OR = 0.94, 95% CI = 0.91 to 0.97, P < .001) and nonwhite patients (OR = 0.90, 95% CI = 0.81 to 1.00, P = .05). Most clinical trial cancer patients across geographical, racial, and practice settings are willing to participate in pharmacogenomic studies. However, to promote equitable benefit to the larger cancer community, optimization of both patient and institutional participation are needed. Institutional factors may be even more compelling than patient demographics. Prospective studies are needed to identify and address barriers/incentives to participation in pharmacogenomic research at the patient, clinician, and institutional levels.
Epidemiology of 3825 injuries sustained in six seasons of National Collegiate Athletic Association men's and women's soccer (2009/2010–2014/2015)
Authors: Karen G Roos, Erin B Wasserman, Sara L Dalton, Aaron Gray, Aristarque Djoko, Thomas P Dompier, Zachary Y Kerr
Journal: British Journal of Sports Medicine (2016)

To describe the epidemiology of National Collegiate Athletic Association (NCAA) men's and women's soccer injuries during the 2009/2010-2014/2015 academic years.This descriptive epidemiology study used NCAA Injury Surveillance Program (NCAA-ISP) data during the 2009/2010-2014/2015 academic years, from 44 men's and 64 women's soccer programmes (104 and 167 team seasons of data, respectively). Non-time-loss injuries were defined as resulting in <24 h lost from sport. Injury counts, percentages and rates were calculated. Injury rate ratios (RRs) and injury proportion ratios (IPRs) with 95% CIs compared rates and distributions by sex.There were 1554 men's soccer and 2271 women's soccer injuries with injury rates of 8.07/1000 athlete exposures (AE) and 8.44/1000AE, respectively. Injury rates for men and women did not differ in competitions (17.53 vs 17.04/1000AE; RR=1.03; 95% CI 0.94 to 1.13) or practices (5.47 vs 5.69/1000AE; RR=0.96; 95% CI 0.88 to 1.05). In total, 47.2% (n=733) of men's soccer injuries and 47.5% (n=1079) of women's were non-time loss. Most injuries occurred to the lower extremity and were diagnosed as sprains. Women had higher concussion rates (0.59 vs 0.34/1000AE; RR=1.76; 95% CI 1.32 to 2.35) than men.Non-time-loss injuries accounted for nearly half of the injuries in men's and women's soccer. Sex differences were found in competition injuries, specifically for concussion. Further study into the incidence, treatment and outcome of non-time-loss injuries may identify a more accurate burden of these injuries.
Abstract OT2-02-05: POSNOC: Positive sentinel node—Adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy: A randomised trial looking at axillary treatment in early breast cancer
Authors: A Goyal
Journal: Cancer Research (2016)

Abstract Background Women with early breast cancer that has spread to 1 or 2 sentinel nodes (SNs) undergo axillary node clearance (ANC) or axillary radiotherapy (ART). The publication of the Z11 trial challenged this practice. There are however concerns about this trial which may limit the interpretation and generalisability of its results. These issues include the proportion of patients with micrometastases, variability in radiotherapy and applicability in patients undergoing mastectomy. Therefore further randomized trials are needed to define the role of axillary treatment in patients with 1 or 2 SNs with macrometastases. The UK-ANZ POSNOC trial is asking this question and will provide a more solid evidence base to inform clinical practice. Methods Trial design: A pragmatic, randomized, multicenter, non-inferiority trial. Interventions: All participants will receive systemic adjuvant therapy according to local guidelines and radiotherapy to breast or chest wall if indicated. Women in the intervention group will receive systemic adjuvant therapy alone, whereas those receiving standard care will receive adjuvant therapy plus ANC or ART. Study population: Women with unifocal or multifocal invasive breast cancer(≤5 cm) undergoing breast conserving surgery or mastectomy, who have 1 or 2 nodes with macrometastases at SN biopsy. The sample size is 1900 women. All participants will be followed up for 5 years. Primary outcome: axillary recurrence at 5 years. Secondary outcomes: arm morbidity, quality of life, anxiety, loco-regional recurrence, distant metastasis; time to axillary recurrence, axillary recurrence-free survival, disease-free and overall survival, contralateral breast cancer, non-breast malignancy and economic evaluation. Key differences from Z11 a) stringent radiotherapy quality assurance program, b) prospective pathology reporting, b) axillary ultrasound is mandatory, b) mastectomy patients are eligible, c) axillary treatment in the standard group may be ANC or ART. Current enrollment 126 patients. Further information Web - www.posnoc.co.uk Email - posnoc@nottingham.ac.uk Citation Format: Goyal A. POSNOC: Positive sentinel node—Adjuvant therapy alone versus adjuvant therapy plus clearance or axillary radiotherapy: A randomised trial looking at axillary treatment in early breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr OT2-02-05.
Lack of Correlation Between Carcinoembryonic Antigen Content of Tumor Extracts and Leukocyte Migration Reactivity of Tumor Patients23
Authors: S. Matzku, M. Zöller, U. Schulz, W. Dietze, H. O. Barth, H.-D. Saeger, M. R. Price
Journal: JNCI Journal of the National Cancer Institute (1980)

Tumor extracts varying in carcinoembryonic antigen (CEA) content (0.4--2,280 ng/mg protein) did not affect the reactivity of cancer patients' leukocytes in the leukocyte migration inhibition test (LMIT). In addition, variations in the plasma CEA levels of tumor-bearing leukocyte donors did not influence the frequency of significant LMIT reactivity.
An unusual finger injury
Authors: David A Pettitt, Ashwin Pai, Emma Bradbury, Suresh Anandan, Mahendra Kulkarni
Journal: BMJ (2016)

A 39 year old female farmer with no medical history presented to the emergency department with a painless swelling over her right index finger. The problem started two weeks earlier after she had been bitten by a lamb. After the injury the finger appeared “bruised.” This bruising continued and a swelling gradually developed. She reported no pain, changes in sensation, or reduced range of movement . 

On clinical examination she was afebrile and haemodynamically stable. Her right index finger exhibited a full range of movement and was neurovascularly intact. The finger was not tender on direct palpation and it seemed to be the same temperature as her other fingers. The finger had a laceration on the radial aspect proximal to the nail fold, with a demarcated and raised area of reddish-blue discoloration measuring about 2 cm × 1.5 cm (fig 1⇓). There was no palpable lymphadenopathy within the axilla.



Fig 1  Injured right index finger



1.  What are the differential diagnoses?

2.  What is the most likely diagnosis?

3.  What investigations might be ordered?

4.  How is this condition managed?

### 1. What are the differential diagnoses?

#### Short answer

Bruising (eg post-trauma), paronychia, herpetic whitlow, orf virus infection, Milker’s nodule, pyogenic granuloma, keratoacanthoma, and osteomyelitis.

#### Discussion

Bruising is a common soft tissue injury (fig 2⇓). It is often secondary to trauma and is characterised by a bluish or purple coloured patch as a result of underlying capillary damage. Bruising is typically painful initially and usually resolves within a few weeks, fading to a greenish-yellow colour before the skin finally returns to normal.



Fig 2  Bruising to the finger. Credit: Dr P Marazzi/Science Photo Library.SPL



In paronychia (fig 3⇓) the infection generally starts in the paronychium at the side of the nail, with local redness, swelling, and pain. The lesion is tender …
A study of therapists' choice of a therapist
Authors: H Grunebaum
Journal: American Journal of Psychiatry (1983)

Twenty-three psychotherapists discussed the criteria that they used when seeking a therapist for themselves. Most of the subjects had had more than one experience with psychotherapy. They sought a therapist who had a reputation for competence, whom they would not encounter frequently outside of therapy sessions, whom they experienced as warm and caring, and who talked rather than remaining silent during the sessions. The significance of these findings for conducting psychotherapy is discussed.
Pelvic Inflammatory Disease
Authors: Margaret Gradison
Journal: JAMA (1977)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comorbidities and inpatient mortality for pemphigus in the U.S.A.
Authors: D.Y. Hsu, J. Brieva, A.A. Sinha, S.M. Langan, J.I. Silverberg
Journal: British Journal of Dermatology (2016)

The morbidity and mortality associated with pemphigus and its treatments have not been fully described. Previous studies have found conflicting results about certain comorbidities and were limited by small sample sizes.To determine the morbidity and mortality from pemphigus and its treatments in the U.S.A.We examined a cross-sectional cohort of 87 039 711 hospitalized patients in the U.S.A. to determine the inpatient comorbidities and mortality of pemphigus.In multivariate survey logistic regression models adjusting for age, sex and race/ethnicity, pemphigus and its treatments were associated with 39 of 122 comorbidities examined. The disorders most strongly associated with pemphigus were Cushing syndrome [adjusted odds ratio (OR) 17·23, 95% confidence interval (CI) 2·41-122·90], adrenal insufficiency (4·08, 1·71-9·73), myasthenia gravis (6·92, 2·55-18·79), mucositis (17·19, 7·73-38·22), herpes infection (7·98, 3·62-17·62), fungal infections (4·03, 3·60-4·52), insomnia (18·02, 2·46-131·88) and hidradenitis (5·34, 1·33-21·43). Among malignancies, only leukaemia (OR 1·56, 95% CI 1·08-2·24) and non-Hodgkin lymphoma (1·52, 1·15-2·03) were associated with pemphigus, but not any solid organ malignancies. Patients with a secondary diagnosis of pemphigus had higher inpatient mortality (3·20%, 95% CI 2·71-3·69) than those with a primary (1·60%, 1·29-1·91) or no (1·78%, 1·78-1·78) diagnosis of pemphigus (P < 0·001).Pemphigus is associated with increased inpatient mortality, likely through its association with numerous comorbid health conditions. Patients with pemphigus require improved access to dermatological care and increased screening for the myriad of comorbidities.
Bone scan had no role in the staging of 765 consecutive operable T1–2N0–1 breast cancer patients without skeletal symptoms
Authors: G. Curigliano, G. Ferretti, M. Colleoni, E. Marrocco, G. Peruzzotti, C. De Cicco, G. Paganelli, A. Goldhirsch
Journal: Annals of Oncology (2001)
Abstract P2-02-13: EpCAM-independent enrichment approach for isolation of circulating tumor cells (CTCs) in breast cancer - What can be found in the EpCAM-depleted fraction?
Authors: T Fehm, H Schneck, B Gierke, M Pawlak, M Templin, D Niederacher, H Neubauer
Journal: Cancer Research (2016)

Abstract Circulating tumor cells (CTCs) are the potential precursors of metastatic disease. Many assays have been established for the enumeration of CTCs. However, major limitations include the reliance on the expression of the cell surface marker epithelial cell adhesion molecule (EpCAM). These approaches may not detect CTCs that either express no/low levels of EpCAM or undergo epithelial-to-mesenchymal transition (EMT). We present an enrichment strategy combining different antibodies specific for surface proteins and extracellular matrix (ECM) components to capture EpCAMneg cell lines and EpCAMneg CTCs from EpCAM-depleted breast cancer blood samples. Expression of proteins (Trop2, CD49f, cMet, CK8, CD44, ADAM8, CD146, TEM8, CD47) was verified by immunofluorescence on EpCAM-positive (e.g. MCF7, SKBR3) and -negative (MDA-MB-231) breast cancer cell lines; antibodies and ECM proteins (e.g. hyaluronic acid (HA), collagen I, laminin) were further spotted in a single- and multi-arrayed format onto glass slides (Schott, NEXTERION® AL) and coupled to immunomagnetic beads (Dynabeads/Adembeads). Tumor cell adhesion of EpCAMpos/neg cell lines was visualized by Coomassie/MitoTracker; EpCAMneg CTCs enriched via functionalized Adem-/Dynabeads were identified by immunofluorescence staining for anti-pan-Cytokeratin(CK)-FITC/anti-CD45 AF647/DAPI and quantified manually by microscopy. Regarding cell lines, marginal binding of EpCAMneg MDA-MB-231 cells to EpCAM-antibodies could be observed. Efficient adhesion/capturing of EpCAMneg cells could be achieved via HA and immobilized antibodies against CD49f and Trop2. By analyzing 29 EpCAM-depleted fractions from 25 metastatic breast cancer patients, we were able to identify EpCAMneg CTCs in 69% of the samples [range 1-24] applying Trop2, CD49f, cMet, CK8 and/or HA magnetic enrichment. Accessorily, EpCAMneg dual-positive (CKpos/CD45pos) cells could be traced in 28 out of 29 samples [range 1-480]. Herein, we demonstrate an enhanced enrichment strategy to optimize capturing of EpCAMneg CTCs by targeting various cell surface antigens with antibody mixtures and ECM components. Thereby, potential relevant CTCs can be gathered and subjected to subsequent molecular analysis. Citation Format: Fehm T, Schneck H, Gierke B, Pawlak M, Templin M, Niederacher D, Neubauer H. EpCAM-independent enrichment approach for isolation of circulating tumor cells (CTCs) in breast cancer - What can be found in the EpCAM-depleted fraction?. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-02-13.
Fluorouracil and low-dose leucovorin versus fluorouracil and high-dose leucovorin: what is the real cost? What is the answer?
Authors: J Brook
Journal: Journal of Clinical Oncology (1995)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1995.13.7.1830 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7677854 Fluorouracil and low-dose leucovorin versus fluorouracil and high-dose leucovorin: what is the real cost? What is the answer? J BrookxJ BrookSearch for articles by this author https://doi.org/10.1200/JCO.1995.13.7.1830 PDF "Fluorouracil and low-dose leucovorin versus fluorouracil and high-dose leucovorin: what is the real cost? What is the answer?." Journal of Clinical Oncology, 13(7), pp. 1830–1831© 1995 by American Society of Clinical Oncology
Reply to Vincenza Conteduca, Cristian Lolli, and Ugo De Giorgi's Letter to the Editor re: Pasquale Rescigno, David Lorente, Diletta Bianchini, et al. Prostate-specific Antigen Decline After 4 Weeks of Treatment with Abiraterone Acetate and Overall Survival in Patients with Metastatic Castration-resistant Prostate Cancer. Eur Urol 2016;70:724–31
Authors: Pasquale Rescigno, Johann S. de Bono
Journal: European Urology (2016)
Panic disorder precipitated by exposure to organic solvents in the work place
Authors: S R Dager, J P Holland, D S Cowley, D L Dunner
Journal: American Journal of Psychiatry (1987)

The authors describe three cases of idiosyncratic response to occupational solvent exposure, with symptoms characteristic of panic disorder (DSM-III). The specific treatment and prognostic implications of this panic-like reaction to solvents are discussed. Sodium lactate infusion is proposed as an objective test to aid in the diagnosis.
Acute abdomen in childhood.
Authors: C DONALD
Journal: BMJ (1967)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Acute abdomen in childhood. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cases of extranodal lymphoma in the head and neck region
Authors: S. Bilge, A. Mayadagli, N. Ozseker, C. Parlak, F. Oruc, N. Ozturk, M. Gumus
Journal: Journal of Clinical Oncology (2007)

18544 Background: Primary extranodal lymphomas of the head and neck region constitute 10–20% of all NHLs. Since they are frequently encountered as localised disease, radiotherapy accounts for the important part in the treatment although other modalities are also available. Cases with the diagnosis of primary extranodal lymphomas of the head and neck region, who administered to our clinic were evaluated retrospectively and presented here. Materials and Methods: Total 13 patients who administered to the Radiation Oncology Clinic of Kartal Education and Research Hospital between years 2000 and 2005, with the diagnosis of primary extranodal lymphoma of the head and neck region were enrolled into the study. All information was gathered from the patients‘ files and evaluated in the electronic environment. Results: Median age was 61 (36–80). Nine patients (69%) were female, and 4 patients (41%) were male. Primary site was found to be tonsil in 8 cases (61%), nasopharynx in 4 cases (30%), and thyroid in one case (7%). Of the 13 cases, 5 (38%) had stage 1, 4 (30%) stage II, 3 (23%) stage III, and 1 (9%) stage IV diseases. Histological type was diffuse large B-cell lymphoma in 8 patients (7 originating from tonsil, 1 from thyroid), T-cell lymphoma in 2 patients (originating from nasopharynx), poorly differentiated histiocytic lymphoma in 1 patient (originating from nasopharynx), and diffuse mixed large B-cell and small B-cell lymphoma in 1 patient. Therapeutic approach was CT+RT in 7 cases, CT+RT+surgery in 3 cases, CT+ surgery in 1 case, RT+ surgery in 1 case, and CT alone in 1 case. Total 44 Gy RT was performed in 22 fractions to involved fields and regional lymph nodes by using cobalt 60 machine. Median 4 cycles of CT that consisted of CHOP were performed to the patients. Of the 13 patients 10 are still under control with no medical problem. One patient with stage 4 disease was lost under treatment after 3 cycles of CT. One case with nasopharyngeal lymphoma was referred due to progression after 2 series of CT, and died 1 month after palliative RT. One case with stage IB tonsil lymphoma received 2 cycles of CT+ RT+ 2 cycles of CT, and died of other medical reason during her 12th month follow up period. Conclusion: Primary extranodal lymphomas of the head and neck region constitute a heterogeneous group of patients, and RT represents an important part of the treatment. No significant financial relationships to disclose.