tbuckley/cabot-search huggingface dataset:
AB0931 Brucellar Spondylodiscitis – a Case Series Analysis
Authors: D. Kaffel, A. Aouadi, I. Cherif, W. Hamdi, I. Zouch, M.M. Kchir
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Brucellar spondylitis is rare. It is also the most prevalent clinical form of osteoarticular involvement in adults infected by Brucella. <h3>Objectives</h3> The aim of this study was to report the clinical, biological, radiological and therapeutic features of brucellar spondylodiscitis. <h3>Methods</h3> Retrospective study including 6 patients followed up in our department between 2006 and 2014. <h3>Results</h3> We studied 6 cases (5 of them are male) with a mean age of 55.3 years old [20 - 83]. 3 patients were consumers of unpasteurized milk. The median delay of consultation was 6 months. All patients had fever, night sweats and generalized weakness. Lumbar spine was affected in 4 cases and cervical spine in 2 cases. Neurologic examination was normal in 5 cases, 1 patient had neurologic deficiency. Plain radiographs revealed narrowing of disc spaces in 5 cases and erosion of the antero-upper corner of the body of vertebra in 1 case. MRI was performed in all cases and revealed features suggesting spondylodiscitis in all patients. Epidural inflammation was found in 4 cases. Disco vertebral biopsy was performed in 1 patient revealing a nonspecific histological appearance and an inconclusive bacteriological study. Laboratory tests including CRP, sedimentation rate and leucocytes were increased in all cases. Rose-Bengale test and Wright test were positive in all of them. They were treated with double antibiotics (Rifadine and Cycline), during an average of 4 months in all cases. All of them had in immobilisation and also had a favourable development. <h3>Conclusions</h3> Brucellar spondylodiscitis may be difficult to diagnose and have an acute or chronic course. Only rapid and correct management may prevent irreversible neurologic deficits and spinal deformities. <h3>Disclosure of Interest</h3> None declared
PTH-105 Salvage hepatectomy in failed portal vein embolisation
Authors: S Iype, S Harper, E Huguet, A Jah
Journal: Gut (2015)

<h3>Introduction</h3> The traditional approach to induce liver hypertrophy of future liver remnant (FLR) is portal vein embolization (PVE). Portal vein ligation (PVL) was also used with successful outcome. Two stage hepatectomy with Association of Portal vein ligation and Partition of Liver (ALLPS)has been in practice recently. We analyse the cases which failed to achieve sufficient hypertrophy following PVE and has been salvaged by two staged hepatectomy. <h3>Method</h3> Our prospective database of 72 cases of PVE over 7 years were analysed and identified 4 cases that didn’t achieve sufficient hypertrophy and subsequently underwent two stage hepatectomy. Patient characteristics, volume increase, postoperative complications and outcomes were analysed. <h3>Results</h3> All 4 patients had extended right hepatectomy. Two patients had colorectal liver metastasis and the other two had hilar cholangiocarcinoma. The staged resections were carried out at an average of 14 days apart. Patient 1 had an FLR of 18%after PVE that increased to 38% after parenchymal transection (stage 1). Patient 2 had an FLR of 25% after PVE which increased to 39% after stage 1 resection. Patient 3 had FLR of 21% after PVE which increased to 34% after stage 1 resection. Patient 4 had FLR volume of 28% with background chronic liver fibrosis that increased to 36% after stage 1. All patients underwent a R0 resection. One patient had postoperative bile leak. There was no operative mortality. <h3>Conclusion</h3> Salvage resection of liver is an effective approach to patients who do not achieve sufficient FLR volume following PVE. <h3>Disclosure of interest</h3> None Declared.
The Role Of Mir-155 In Controlling Key Growth and Survival Pathways In ABC-Subtype DLBCL
Authors: Lan V Pham, Muychi T Vang, Archito T. Tamayo, Zhishuo Ou, Alex Rollo, Liang Zhang, Erin M Dominici, Elyse R Lopez, James Pham, Jack Wang, Lauren M Strickland, Michael Wang, Richard J. Ford
Journal: Blood (2013)
At last, a rational way to pay for physician's services?
Authors: J. S. Todd
Journal: JAMA (1988)

Change is the one constant in health care today. New technologies, emerging diseases, an aging population, economic and budgetary pressures, and just plain politics are exerting a profound effect on how we physicians care for our patients. Like life's passage, change is indifferent to whether one likes it or not. If change cannot be avoided, at least it can be influenced by reason and goodwill. The American Medical Association (AMA) has attempted to do just that for the vexing question of how Medicare should pay for physicians' services. At least four years ago, the AMA concluded that change was coming in this area. New and often frightening "solutions" were being proposed to deal with what was fundamentally a budgetary problem: expenditures under Part B of Medicare for physicians' services were more than the federal government believed it could afford. The Association's Board of Trustees and House of Delegates understood well
Massachusetts Medical Society
Authors: Lamar Soutter
Journal: New England Journal of Medicine (1980)

JAMES M. FAULKNER, M.D.On January 18, Dr. James M. Faulkner died in Boston at the age of 81. He was widely known as a medical educator. The son of a general practitioner, he graduated from the Harvard Medical School in 1924. After a period of medical training at the Massachusetts General Hospital, Rockefeller Institute, and Johns Hopkins, he joined the Harvard faculty and began his career in academic medicine. He had two periods of military service, the first as an ordinary soldier in World War I, when he received the Croix de Guerre for rescuing a wounded man under . . .
PSYCHODYNAMIC CONSIDERATIONS IN GILLES DE LA TOURETTE'S DISEASE (<i>MALADIE DES TICS</i>)
Authors: EDUARD ASCHER
Journal: American Journal of Psychiatry (1948)

1. Gilles de la Tourette's disease is a relatively uncommon disorder, there being only 4 cases on record among approximately 9,000 inpatient and 50,000 outpatient admissions to the Henry Phipps Psychiatric Clinic. 2. In 4 of 5 cases the patient was either foreign-born or first generation American-born. One of the parents was rigid and domineering, it being the father in four of the 5 cases. 3. The patients were all obedient, well-behaved, and somewhat perfectionistic as children but showed a marked change in behavior at the time of onset of the illness. 4. In all instances a history of a precipitating event was given; however, there was evidence that, in some patients at least, the symptoms were present prior to this event. 5. Although the meaning of the motor movements was not entirely understood, the symptoms of echolalia and coprolalia appeared to be related to certain attitudes the patient had toward one or both parents (or husband) and also constituted an attempt to suppress their expression. 6. Inasmuch as coprolalia interferes with the patient's acceptance by his environment, even though it might temporarily decrease his anxiety over his hostile feelings, a basis for a psychotic withdrawal is established. 7. There is considerable resemblance of the clinical manifestations of Gilles de la Tourette's disease to the symptomatology of schizophrenia, particularly as regards stereotyped mannerisms and speech. 8. In the cases reported here neither clinical nor laboratory examinations were indicative of organic disease. Although there was emotional maladjustment among some family members, a hereditary factor in the etiology of the illness appeared unlikely. 9. Regardless of the therapist's concept of etiology, psychiatric treatment should be prompt, aided by the useful employment of the knowledge gained from the understanding of the patient's symptoms in terms of his attitudes and personality functioning. 10. The therapeutic efforts might possibly be hampered by the presence of central nervous system pathology, even though this is hardly supported by clinical evidence; postmortem examination should prove helpful to throw more light on this matter.
Appendicitis and Infectious Diseases
Authors: L PODHRAGYAY
Journal: JAMA (2015)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Toward a biochemical classification of depressive disorders, VI: Platelet MAO activity and clinical symptoms in depressed patients
Authors: J E Gudeman, A F Schatzberg, J A Samson, P J Orsulak, J O Cole, J J Schildkraut
Journal: American Journal of Psychiatry (1982)

The authors compared platelet monoamine oxidase (MAO) activity with clinical signs and symptoms in 32 patients with unipolar depressions. There was a statistically significant positive correlation between platelet MAO activity and scores on the Hamilton Rating Scale for Depression and between platelet MAO activity and specific clinical signs and symptoms in the spheres of depression, psychic anxiety, and somatic complaints. The clinical items found to be related to platelet MAO activity correspond to symptoms reported by other investigators to be associated with favorable responses to treatment with MAO inhibitors.
Public health response to an avian influenza A (H5N1) poultry outbreak in Suffolk, United Kingdom, in November 2007
Authors: S Munasinghe, G Brown, A Pereira, B Keeble, P Nair, T Sundkvist
Journal: Eurosurveillance (2008)

An outbreak of highly pathogenic avian influenza (HPAI) H5N1 in a poultry farm in Suffolk, United Kingdom, in November 2007 prompted a comprehensive public health response to stop the transmission of avian influenza to humans. A total of 176 of 178 potentially exposed (99%) received oseltamivir prophylaxis. The majority of them, 169 people (96%), received the influenza vaccine during the outbreak. Thirty people who had been given post-exposure prophylaxis were actively followed up for one week. None of them developed symptoms suggestive of influenza-like illness. Serological investigation (28-day testing) of those who reported symptoms is ongoing.
A failed welfare state
Authors: Richard Hurley
Journal: BMJ (2016)

The film I, Daniel Blake , a bleak look at the failures of the UK welfare system, has won the coveted Palme d’Or prize at the recent Cannes film festival. Directed by Ken Loach, the film centres on Daniel Blake, a fictional 59 year old joiner who has worked for most of his life.

After a heart attack, doctors tell …
TMIC-10PLEIOTROPY OF TUMOR-ASSOCIATED MYELOID CELLS WITHIN HUMAN GLIOBLASTOMA
Authors: Konrad Gabrusiewicz, Jun Wei, Yuuri Hashimoto, Benjamin Rodriguez, Maiti Sourindra, Brandon Liebelt, Luke Healy, Roeland Verhaak, Raversanker Ezhilarasan, Shouhao Zhou, Neal Huang, Jefffrey Weinberg, Sujit Prabhu, Ganesh Rao, Raymond Sawaya, Frederick Lang, Eric Sulman, Laurence Cooper, Jack Antel, Amy Heimberger
Journal: Neuro-Oncology (2015)
Massachusetts Medical Society
Authors: Claude E. Welch
Journal: New England Journal of Medicine (1970)

About 10 years ago President Johnson authorized the Commission on Heart Disease, Cancer and Stroke with the intent that these three important "killer" diseases might be controlled better than they had been in the past. The Commission reported in 1964, and as a result, PL. 89–239, which authorized the regional medical programs (RMPs), became law in 1965. Just five years have passed since that time. It seems appropriate, therefore, to report to the Massachusetts Medical Society the steps that have been taken to create a viable program and to indicate the relation of the medical profession to the present system. . . .
Evolutionary Consequences of DNA Methylation in a Basal Metazoan
Authors: Groves B. Dixon, Line K. Bay, Mikhail V. Matz
Journal: Molecular Biology and Evolution (2016)

Gene body methylation (gbM) is an ancestral and widespread feature in Eukarya, yet its adaptive value and evolutionary implications remain unresolved. The occurrence of gbM within protein-coding sequences is particularly puzzling, because methylation causes cytosine hypermutability and hence is likely to produce deleterious amino acid substitutions. We investigate this enigma using an evolutionarily basal group of Metazoa, the stony corals (order Scleractinia, class Anthozoa, phylum Cnidaria). We show that patterns of coral gbM are similar to other invertebrate species, predicting wide and active transcription and slower sequence evolution. We also find a strong correlation between gbM and codon bias, resulting from systematic replacement of CpG bearing codons. We conclude that gbM has strong effects on codon evolution and speculate that this may influence establishment of optimal codons.
AB0806 Skeletal Dimorphisms are Independently Related to Musculo-Skeletal Discomfort in a Cohort of Psoriatic Subjects
Authors: G. De Marco, P. Gibertini, A. Cattaneo, C.G. Carrera, N. Battafarano, A. Marchesoni
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Musculo-skeletal discomfort stands as the main clinical clue whenever psoriatic subjects are sent for rheumatological referral. Although skeletal dimorphisms (such as scoliosis, varus deformity of the knees, flat feet and so on) may play a role in the occurrence of painful symptoms, such issue is still poorly investigated. <h3>Objectives</h3> Our aim was to investigate the influence of skeletal dimorphisms on musculo-skeletal discomfort in a series of patients with mild psoriasis subjects, in comparison to other factors. <h3>Methods</h3> Among the psoriatic patients routinely followed-up in a dermatological clinic dedicated to psoriasis care, a cohort of 307 consecutively enrolled subjects was established for an epidemiological study. Patients on biological treatment and those unable to give informed consent were not eligible. All candidates underwent a thorough rheumatological evaluation. Details about history of pain and skeletal dimorphisms were collected as well. Imaging and laboratory investigations were performed as needed. Diagnosis was established through expert opinion. <h3>Results</h3> The 307 studied patients had mean age of 53.8 years (SD 16.3); 188 (61.2%) were males. Median psoriasis duration was 11 years (IQR 4.5-20), median PASI score was 3.1 (IQR 1.6-6.5). Systemic therapies were prescribed to 91 (29.6%) subjects. Pain on examination was observed in 105 patients (34.2%). In this series, female gender, obesity and the presence of skeletal dimorphisms were all significantly related to pain on examination, while current smoking and age at the time of enrolment were not. In particular, the comparison between the several age classes composing this series (bounded by decades) did not highlight any statistically significant differences. At univariate analysis, gender seemed to be more frequently related to the presence of musculo-skeletal pain, even among obese psoriatic subjects (P&lt;0.05). A significantly higher proportion of skeletal dimorphisms was found in females as well (P&lt;0.05). The multivariable analysis, performed through unconditional logistic regression showed that skeletal dimorphisms remained an independent factor related to pain on examination as well as gender and obesity. <h3>Conclusions</h3> In this study, skeletal dimorphisms were unexpectedly found to be related to musculo-skeletal discomfort, independently from obesity and gender. The influence of that kind of disorders on psoriatic disease needs to be further investigated, in order to establish its significance on the natural history of this condition. <h3>Disclosure of Interest</h3> None declared
The coordination of mental health services at the neighborhood level
Authors: J F Borus, L A Janowitch, F Kieffer, R G Morrill, L Reich, E Simone, L Towle
Journal: American Journal of Psychiatry (1975)

The neighborhood health center is becoming a major locus of mental health care delivery. Because of their strategic position at the neighborhood level, mental health care systems in the comprehensive health center locus have been able to develop linkages with both general health and community mental health systems to provide a broad continuum of coordinated health and mental health care. Four models identified in a survey of 19 neighborhood mental health programs are described. The authors suggest that persistent problems in coordination of care between neighborhood mental health and other caregiving systems would be considerably alleviated by a fiscal reimbursement scheme that rewarded integration rather than fragmentation of care.
AB0570 The Role of Minor Salivary Gland Biopsy in SjÖgren's Syndrome: A Single Centre Experience
Authors: F. Aguiar, G. Terroso, J. Abelha-Aleixo, D. Rosa-Gonçalves, R. Fonseca, R. Vieira, P. Madureira, I. Brito, L. Costa
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Minor salivary gland biopsy (MSGB) is a simple procedure that can be used for the diagnosis of Sjögren9s syndrome (SS) and other infiltrative diseases, such as amyloidosis, hemochromatosis, and sarcoidosis. The revised version of the European criteria from the American-European Consensus Group (AECG) in 2002 defined that MSGB with a focus score ≥1 (defined as a number of inflammatory infiltrates of at least 50 cells in 4 mm<sup>2</sup> of gland surface unit), is a major criteria for SS classification. MSGB is also included in American College Rheumathology Classification criteria for SS. <h3>Objectives</h3> To describe the diagnostic usefulness and safety of MSGB performed in our centre in the evaluation of suspected SS. <h3>Methods</h3> In this study, the authors retrospectively analyzed the clinical and laboratory findings of all patients seen at our centre who underwent a MSGB for suspected SS from January 2013 to February 2015. The data collected included demographic, clinical, serologic and histological features. Patients were classified according to the AECG criteria. <h3>Results</h3> A total of 93 MSGB were performed for suspected SS – 11 patients for secondary SS (6 previously diagnosed with rheumatoid arthritis, 2 with systemic upus erythematosus, 1 with rhupus, 1 with systemic sclerosis and 1 with autoimmune hepatitis) and 82 with suspected primary SS. Of the 93 MSGB, 91 (97.8%) samples provided adequate material for histologic analysis, however 3 other patients were excluded because of lack of clinical and laboratorial information. Eighty-two patients were women, with a mean age of 50,8±12 years old. Eighty-six patients had sicca symptoms: 90,7% presented xerostomy and 80,2% xerophtalmia. Twenty-seven patients (30,7%) were positive for antibodies anti-SSa or anti-SSb. Twenty-six patients (29,5%) had a focus score ≥1, and 20 (94.5%) of these 26 satisfied the AECG criteria. Classification of SS was possible for 32 (36.3%) of 88 patients. In 12 (37,5%) of the 32 patients, MSGB was essential to reach the number of criteria needed for classification. There were no immediate or late complications with the procedure. <h3>Conclusions</h3> Despite the limitations of this study, which is retrospective and has a small sample size, it can be concluded that MSGB is a simple, safe, and useful tool in the evaluation of suspected of SS. It should be performed whenever there is a suspicion of SS but there are not sufficient criteria met to make the diagnosis. <h3>Disclosure of Interest</h3> None declared
SP0253 Introducing the Concept of Self-Management in Southern Europe. Challenges of the Agora Partner in Treatment Initiative
Authors: C. Zabalan
Journal: Annals of the Rheumatic Diseases (2015)

“Self-management relates to the tasks that an individual must undertake to live well with one or more chronic conditions. These tasks include gaining confidence to deal with medical management, role management, and emotional management”. (Adams, Greniner, &amp; Corrigan 2004) The common socio-economic circumstances existing in almost all Southern Europe countries affect the quality of life for people with RMDs and managing a chronic illness is a time consuming and complex process. Yet, rarely it is chronically ill patients themselves called on to involve in the management of the factors that contribute to their health. The need to face such a common problem in a more organized way and to empower patient organizations in offering their members efficient methods for reaching a state of complete physical, mental and social well-being led to the Partner In Treatment initiative. www://agora-pait.com/ Future challenges like changing mentalities of all stakeholders to be involved (patients, HPs and other decision makers), lack of funds and time, motivation, priorities, acting as a team, valuing the diversity of experiences and ideas within the practice and many other factors have been emphasized as barriers to overcome in an Agora Southern countries survey. Now let9s find the solutions. Writing a companion guide for disease management and communication with medical specialists, writing quick cards for both patients and HPs, uniting them in a common dialogue, speaking the same language, organising a course for training trainers in self-management, offering financial support for translating the materials are just the first important steps (guided and supervised by Agora association) in overcoming the barriers and implementing such a course in Southern European countries. The battle of the Southern countries has started. And this is a special battle because there will only be winners at the end process because we fight for enabling people to increase control over the disease and to improve their health. Whatever team you are playing in (patients, rheumatologists, HPs, researchers in medicine, decision makers, industry, pharma, psychologists, consultants in healthy living and personal development etc.) you are most welcome to join the presentation and help promote self-management and healing because the best way to get something done is to begin. <h3>Disclosure of Interest</h3> None declared