tbuckley/cabot-search huggingface dataset:
THU0462 Anti-Citrullinated Peptide/Protein Antibody (ACPA)-Negative RA Shares Large Proportion of Susceptibility Genes with Acpa-Positive RA
Authors: C. Terao, K. Ohmura, K. Ikari, Y. Kochi, Y. Okada, M. Shimizu, T. Kawaguchi, M. Takahashi, K. Myouzen, A. Suzuki, M. Kubo, R. Yamada, A. Taniguchi, H. Yamanaka, S. Momohara, K. Yamamoto, F. Matsuda, T. Mimori
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Susceptibility genes for anti-citrullinated peptide/protein antibodies (ACPA)-positive rheumatoid arthritis (RA) have been successfully discovered by the development of genome-wide association studies (GWAS). However, little is known about the genetic background of ACPA-negative RA. <h3>Objectives</h3> We intended to clarify genetic background of ACPA-negative RA and compare susceptibility genes between ACPA-negative and -positive RA. <h3>Methods</h3> We performed a meta-analysis of GWAS comprising 670 ACPA-negative RA and 16,891 controls for 1,948,138 markers, followed by a replication study of the top 35 SNPs using 916 cases and 3,764 controls. Inverse-variance method was applied to assess overall effects. To assess overlap of susceptibility genes between ACPA-positive and -negative RA, odds ratios (ORs) of the 21 susceptibility markers to RA in Japanese were compared between the two subsets. In addition, SNPs were stratified by the p-values in GWAS meta-analysis for either ACPA-positive RA or ACPA-negative RA to address the question whether weakly-associated genes were also shared. The correlations between ACPA-positive RA and the subpopulations of ACPA-negative RA (rheumatoid factor (RF)-positive and RF-negative subsets) were also addressed. <h3>Results</h3> Rs6904716 in <i>LEMD2</i> of the HLA locus showed a borderline association with ACPA-negative RA (overall p=5.7x10<sup>–8</sup>), followed by rs6986423 in <i>CSMD1</i> (p=2.4x10<sup>–6</sup>) and rs17727339 in <i>FCRL3</i> (p=1.4x10<sup>–5</sup>). ACPA-negative RA showed significant correlations of ORs with ACPA-positive RA for the 21 susceptibility SNPs and non-HLA SNPs with p-values far from significance. These significant correlations with ACPA-positive RA were true for ACPA-negative RF-positive and ACPA-negative RF-negative RA. On the contrary, positive correlations were not observed between the ACPA-negative two subpopulations. <h3>Conclusions</h3> Many of the susceptibility genes were shared between ACPA-positive and -negative RA. <h3>Acknowledgements</h3> We9d like to thank all doctors who helped us to collect DNA samples from patients with ACPA-negative RA. We9d like to thank especially Drs. Takao Fujii, Hiromu Ito, Motomu Hashimoto and Moritoshi Furu for their effort for sample accumulation. <h3>Disclosure of Interest</h3> : None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3219
Abstract 1789: NFKBIA deletion in malignant gliomas
Authors: Markus Bredel, Ajay Yadav, Jaclyn Renfrow, Denise Scholtens, James Chandler, Claudia Bredel, Michael Tagge, Paul Lukac, Pierre Robe, Hannes Vogel, Adrienne Scheck, Kenneth Aldape, Arnab Chakravarti, Griffith Harsh
Journal: Cancer Research (2010)

Abstract Introduction: Aberrant activation of the Epidermal Growth Factor Receptor (EGFR) oncoprotein is a molecular hallmark of glioblastomas. Two-thirds of tumors with excessive EGFR activation show alteration of the EGFR gene. The mechanism of deregulation of EGFR in the other third remains poorly understood. Nuclear factor of κB inhibitor alpha (NFKBIA) is a potential tumor suppressor. Methods: Multidimensional molecular profiles for NFKBIA and EGFR and clinical profiles of 732 malignant glioma patients from multiple academic institutions, The Cancer Genome Atlas Pilot Project, the Repository of Molecular Brain Neoplasia Data, and a randomized phase III trial of temozolomide. NFKBIA mutational and functional analyses in a glioblastoma cell model. Results: We found that about 25% of glioblastomas harbor heterozygous NFKBIA gene deletions at chromosome 14q13. NFKBIA functions as a haploinsufficient tumor suppressor in glioblastomas by terminating EGFR signaling. Tumors with NFKBIA deletion lacked EGFR amplifications, indicating functional redundancy of both genetic events in glioblastoma pathogenesis. Loss of NFKBIA gene dosage was significantly associated with briefer patient survival. Patients with low NFKBIA expression had a significantly worse outcome than patients with intact NFKBIA expression. NFKBIA expression was also significantly associated with patient survival in subsets of tumors with unmethylated promoter of the O6-methylguanine DNA methyltransferase (MGMT) gene. A combined outcome predictor model of NFKBIA and MGMT proved highly predictive of duration of survival. Conclusion: Deletion of NFKBIA is an alternative mechanism for tumorigenic increase in EGFR signaling in glioblastomas. NFKBIA inactivation is associated with shorter survival of patients with malignant gliomas. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1789.
Effect of Growth Hormone Treatment on the Adult Height of Children with Chronic Renal Failure
Authors: Dieter Haffner, Franz Schaefer, Richard Nissel, Elke Wühl, Burkhard Tönshoff, Otto Mehls
Journal: New England Journal of Medicine (2000)

Growth hormone treatment stimulates growth in short children with chronic renal failure. However, the extent to which this therapy increases final adult height is not known.
Tuberculosis Transmission from a Patient with Skin Lesions and a Negative Sputum Smear
Authors: Jason E. Stout, John J. Engemann, Carol D. Hamilton
Journal: New England Journal of Medicine (2004)

terleukin-7 receptor is crucial for the normal development of T cells, whereas the interleukin-15 receptor is necessary for the normal development of natural killer cells.Patients with X-linked SCID generally have normal numbers of B cells that function poorly because of the lack of T-cell help.Adenosine deaminase deficiency is the cause of SCID that would result in the T¡B¡NK¡ phenotype.Patients with adenosine deaminase deficiency are not candidates for this type of gene therapy.
Tips for Giving a Memorable Presentation, Part III
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2012)

Composing an important formal presentation takes much thought and time. The lecturer should talk about what the audience wants or needs to hear. It is not advised to speak about a subject that is important to the presenter and not the audience. The speaker then needs to decide what he or she can offer to the audience, and what he or she wants them to think about, learn, or do after the talk is over. These considerations are critical to the composition of the presentation.
Functional Electrocardiographic Abnormalities
Authors: Henry Wilde
Journal: New England Journal of Medicine (1958)

As a result of increasing routine clinical use of electrocardiography, scattered reports have appeared in the literature of RST-segment and T-wave abnormalities occurring in younger patients in the absence of demonstrable cardiovascular disease.1 2 3 Transient electrocardiographic abnormalities of this type have been related to fear, anxiety and emotional stress.4 5 6 7 Reassurance and sedation, as well as the use of anticholinergic substances2 and ergotamine tartrate,8 have resulted in a prompt return of the tracings to normal when such further studies were carried out. Epinephrine,9 acetylcholine,7 hyperventilation,10 the anticipation of painful procedures9 and discussion of distressing topics5 have been found capable of inducing isolated . . .
306 Pin1 IS DECREASED IN ISCHEMICALLY DAMAGED LIVER AND SUPPRESSED LIVER REGENERATION AFTER HEPATECTOMY THROUGH THE INHIBITION OF Pin1-MEDIATED NF-κB ACTIVATION IN HEPATOCYTES
Authors: S. Kuboki, K. Shinoda, H. Shimizu, S. Maeda, H. Yoshidome, M. Ohtsuka, A. Kato, H. Yoshitomi, K. Furukawa, T. Takayashiki, D. Okamura, D. Suzuki, M. Nakajima, T. Aida, M. Miyazaki
Journal: Journal of Hepatology (2013)
Abstract P3-02-02: Use of contrast-enhanced computed tomography in clinical staging of asymptomatic breast cancer patients to detect asymptomatic distant metastases.
Authors: S Tanaka, N Sato, H Fujioka, Y Takahashi, K Kimura, M Iwamoto, K Uchiyama
Journal: Cancer Research (2012)

Abstract Objective: The use of computed tomography (CT) with regards to the clinical staging of breast cancer (BC) patients has been on the increase in clinical practice. However, NCCN guidelines recommended the use of imaginng only in cases with locally advanced disease or signs of distant metastases (DM), and the benefits of routine CT have yet to be fully clarified. This study investigated the value of employing contrast-enhanced CT (CECT) to screen for DM in patients with asymptomatic BC. Methods: The clinical records of 483 patients with asymptomatic BC who underwent CECT, also in order to detect BC spread, between April 2006 and January 2011 were reviewed. The CECT results were classified into normal, true-positive (metastases) or false-positive findings. Results: Abnormal CECT findings, including true- and false-positive results, were detected in 65 patients (13.5%). Of these, 26 patients (5.4%) showed confirmed true metastatic disease, including 18 lung metastases, 11 liver metastases and 13 bone metastases. Upstaging to stage IV due to the results of the CECT was significantly associated with only larger tumos size (odds ratio, 33.4; 95% CI 12.1–92.5; P &amp;lt; 0.0001) and lymph node status (odds ratio, 37.1; 95% CI 14.2–96.8; P &amp;lt; 0.0001.) Upstaging to stage IV occurred in 0 of 155 patients at stage I, 5 of 261 patients (1.9%) at stage II and 21 of 67 patients (31.3%) at stage III. Conclusions: Routine CECT did not appear to be useful for detecting DM in completely asymptomatic patients. Conversely, a small number of patients were upstaged from early to stage IV and a predictive factor beyond T and N stage alone appears to be needed in order to predict which asymptomatic patients have DM. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P3-02-02.
SAT0047 Impact of Anti-Rheumatic Treatment on Immunogenicity of Pandemic H1N1 Influenza Vaccine in Patients with Arthritis
Authors: M. C Kapetanovic, T. Saxne, A. Mörner, T. Aktas, L. E. Kristensen, P. Geborek
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> A monovalent, adjuvanted, inactivated H1N1 influenza vaccine (Pandemrix) was reported as highly immunogenic resulting in seroconversion in 77-94% of adults after administration of a single dose (ref). <h3>Objectives</h3> To investigate impact of different anti-rheumatic treatments on antibody response following H1N1 vaccination in patients with rheumatoid arthritis (RA) and spondylarthropathy (SpA). <h3>Methods</h3> Patients with arthritis (n=333; mean age 58 years, 66% women) participated. Hemagglutination inhibition (HI) assay was performed on blood samples drawn prior to and after mean 8 months following vaccination. A positive immune response was defined as seroconversion i.e. ≥4-fold increase in HI titer or HI ≥40 in case ofa negative pre-vaccination serum. There were 7 treatment groups: RA on MTX; RA on anti-TNF monotherapy; RA on anti-TNF+MTX; RA on other biologics (abatacept, rituximab, tocilizumab); SpA on anti-TNF monotherapy; SpA on anti-TNF+MTX and SpA on NSAIDs/analgesics. <h3>Results</h3> The figure shows percentages of patients with positive immune responses in different treatment groups. RA patients on rituximab had significantly lower (p&lt;0.001) and SpA on anti-TNF monotherapy significantly better response rates compared to other treatment groups (p 0.001-0.032). No significant differences were found between other groups. <h3>Image/graph</h3> <h3>Conclusions</h3> Rituximab treatment is associated with severely reduced antibody response to the pandemic H1N1 influenza vaccine. Eight months after vaccination, antibody response in SpA patients on anti-TNF monotherapy was still as good as that reported for healthy adults efter 3-4 weeks. All other treatments groups showed lower antibody response. <h3>References</h3> Broadbent AJ, Subbarao K. Current Opinion in Virology 2011 (1);4:254-262. <h3>Disclosure of Interest</h3> None Declared
Utility of double-balloon enteroscopy in patients with left ventricular assist devices and obscure overt gastrointestinal bleeding
Authors: Adam Edwards, Klaus Mönkemüller, Salpy Pamboukian, James George, C. Wilcox, Shajan Peter
Journal: Endoscopy (2014)

Obscure overt gastrointestinal bleeding (OGIB) is a challenge in patients with left ventricular assist devices (LVADs). We evaluated the utility and safety of double-balloon enteroscopy (DBE) in patients with LVADs in an observational consecutive-patient cohort from a single tertiary referral center. Ten patients with LVADs underwent thirteen DBEs for obscure OGIB. The first OGIB event necessitating DBE occurred after a mean of 512 ± 363 days of LVAD support. All patients underwent DBE, eleven anterograde and two retrograde, with a mean insertion depth 176 ± 85 cm. Diagnostic yield was 69 % with the primary bleeding lesion most frequently found in the mid-bowel. The most common lesions were arteriovenous malformations. Therapeutic yield with argon plasma coagulation (APC), epinephrine injection, and/or hemoclip placement was 89 %. There were no procedure-related complications. DBE in patients with LVADs has good diagnostic yield and high therapeutic yield for obscure OGIB and is safe and well tolerated.
67Ga SPECT/CT Accurately Localized Recurrent Hepatic Cyst Infection in Patients With Autosomal Dominant Polycystic Kidney Disease
Authors: Sally Louise Ayesa, Denis J. Gradinscak, Geoff P. Schembri
Journal: Clinical Nuclear Medicine (2014)

Hepatic pyocyst is a rare but potentially life-threatening complication of autosomal dominant polycystic kidney disease. With extensive hepatic cystic disease, localization of a pyocyst and targeted aspiration or drainage is often a diagnostic challenge. Two patients with autosomal dominant polycystic kidney disease and recurrent gram-negative sepsis were imaged with 67Ga SPECT/CT for investigation of an infective source. In both patients, imaging accurately localized infected pyocysts and guided percutaneous drainage and further management.
Abstract 4416: Significance of IGF-1R and Its signaling pathways in human sarcoma
Authors: Jia Lin Yang, Romi DasGupta, Alyse Hopkins, Frederick Luk, David Goldstein, Philip Crowe
Journal: Cancer Research (2011)

Abstract A 5-year 50% survival rate reflects the inadequacy of available therapies. We aimed to investigate the relationship of IGF-1R signaling factor expression with clinicopathological parameters of soft tissue sarcoma (STS) and patient outcome, as well as the therapeutic effect of targeting IGF-1R combined with chemotherapy in sarcoma cell lines. Tissue-microarray and immunohistochemistry were used to detect expression of IGF-1R and its signaling factors, pAkt, pERK, pp38, pJNK and pSTAT3 in 93 samples from 89 STS patients. Combination therapy using IGF-1R inhibitor and each of 5 chemotherapueutic agents was investigated in 11 sarcoma cell lines and analysed by Chou-Talalay method. Mechanism studies were also performed. A strong link between stage and grade with expression of IGF-1R (p&amp;lt;0.033 and p&amp;lt;0.042), pAkt (p&amp;lt;0.004 and p&amp;lt;0.001) and pERK (p=0.002 and p&amp;lt;0.001) in STS was found. Decreased survival correlated with pAkt expression (Multivariate Cox regression p=0.043). Combination treatment of IGF-1R inhibitor with individual chemotherapeutic agents achieved synergistic anti-proliferative effect for all drugs except gemcitabine in some sarcoma cell lines (5/11 carboplatin, 3/11 ifosfamide, 3/11 docetaxel, and 3/11 doxorubicin), accompanied by apoptosis and cytotoxicity. Furthermore, characterisation of IGF-1R signaling interaction by downstream pathway inhibition revealed the importance of activated PI3K and p38 for chemoresistance in a pair of liposarcoma cell lines (synergistic, 778 and antagonistic, SW872). IGF-1R, pAkt and pERK may be predictors of the aggressiveness of STS. IGF-1R inhibition in combination with chemotherapy is a worthwhile strategy to pursue in anti-sarcoma therapy. These results provide a rationale for further clinical evaluation. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 4416. doi:10.1158/1538-7445.AM2011-4416
18F-FDG PET/CT Findings Preceded Elevation of Serum Proteinase 3 Antineutrophil Cytoplasmic Antibodies in Wegener Granulomatosis
Authors: Kimiteru Ito, Ryogo Minamimoto, Hiroyuki Yamashita, Miyako Morooka, Momoko Okasaki, Akio Mimori, Kazuo Kubota
Journal: Clinical Nuclear Medicine (2013)

A 67-year-old woman underwent 18F-FDG PET/CT after developing a fever of unknown origin. PET/CT revealed intensive FDG uptake at the nasal and lung lesions. On the laboratory data, serum myeloperoxidase antineutrophil cytoplasmic antibodies (ANCA) titer was elevated, although serum directed against proteinase 3 (PR3) ANCA titer was within normal limits. One month after treatment, follow-up PET/CT revealed decreased FDG uptake at the lesions. One year later, serum PR3-ANCA titer elevated, which finally led to a diagnosis of Wegener granulomatosis (WG). WG lesions may be detected earlier by FDG PET/CT than by serum PR3-ANCA titers.
Abstract 1131: ING4 attenuates breast cancer cell growth in Matrigel by altering Wnt/beta-catenin signaling pathway
Authors: Stefanie L. Raymond-Whish, Suwon Kim
Journal: Cancer Research (2010)

Abstract ING4 is a member of the INhibitor of Growth (ING) tumor suppressor family, which plays a role in various cellular processes and suppresses hallmarks of cancer. ING4 contains a plant homeodomain (PHD) finger motif that has been implicated in transcriptional regulation via chromatin remodeling. However, the molecular mechanism(s) of ING4 tumor suppressor function is not known. In breast cancer, the ING4 locus is deleted in 10-20% of primary tumors, suggesting its role as a tumor suppressor. To better understand tumor suppressive function of ING4 in breast cancer, we tested whether ING4 can influence cell growth in three-dimensional culture environment using Matrigel. We found that ING4 retarded proliferation of T47D human breast cancer cells in Matrigel. In order to identify downstream target genes of ING4 that may be responsible for this activity, we employed gene expression profiling assays. The results showed that ING4 down-regulated several genes in the Wnt/β-catenin pathway, including Wnt4, Wnt6, dishevelled 1, dishevelled 3, and frizzled 4. Deregulation of the Wnt/β-catenin signaling pathway has been shown in human breast cancer as well as to induce mammary tumors in mice. We conclude that ING4 attenuates T47D cell growth in Matrigel by down-regulating the Wnt/β-catenin signaling pathway. Our data suggests that ING4 may function as a tumor suppressor in breast cancer by suppressing Wnt/β-catenin signals. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1131.
Heparin-Induced Thrombocytopenia in Patients Treated with Low-Molecular-Weight Heparin or Unfractionated Heparin
Authors: Theodore E. Warkentin, Mark N. Levine, Jack Hirsh, Peter Horsewood, Robin S. Roberts, Michael Gent, John G. Kelton
Journal: New England Journal of Medicine (1995)

Heparin-induced thrombocytopenia, defined by the presence of heparin-dependent IgG antibodies, typically occurs five or more days after the start of heparin therapy and can be complicated by thrombotic events. The frequency of heparin-induced thrombocytopenia and of heparin-dependent IgG antibodies, as well as the relative risk of each in patients given low-molecular-weight heparin, is unknown.
Case 33-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Richard Masters, Thomas J. Flotte
Journal: New England Journal of Medicine (1986)

Presentation of CaseA 62-year-old man was admitted to the hospital because of confusion and ataxia.There was a long history of alcohol abuse, with upper gastrointestinal bleeding of uncertain source 15 years earlier. One month before admission he had an upper respiratory tract infection, with chilliness and questionable fever that persisted for two weeks. Two weeks before entry the patient was discharged from his job as a baker because of weakness. He was separated from his family, who saw him at that time and noted that he had a tendency to list to the left on walking, although he . . .
Invite all donors to participate in follow-up studies
Authors: W. E. Moody, C. J. Ferro, C. D. Chue, N. C. Edwards, R. P. Steeds, J. N. Townend
Journal: BMJ (2012)

Garg and colleagues provide new data that contribute greatly to our understanding of the long term consequences of living kidney donation.1 However, although they tried to match donors with non-donor controls, it is hard to determine whether the groups were truly comparable because information on blood pressure is lacking. …
ENDOSCOPY IN HUMANS: UNA HERRAMIENTA 3D INTERACTIVA PARA LA FORMACIÓN EN ENDOSCOPIA
Authors: J Usón, A Cristo, M Fernández, F Soria, E Morcillo, M Suárez, JM Fernández, A Rodríguez, F Sánchez
Journal: Endoscopy (2014)

Introducción: En el campo de la Medicina son muy importantes la seguridad al aplicar las técnicas diagnósticas (básicas o avanzadas), el cuidado óptimo del paciente y la garantía de la calidad. Por ello, la formación y entrenamiento del especialista adquieren un matiz de gran relevancia que puede ser potenciado por las nuevas tecnologías.
Tc-99m HMPAO Brain SPECT Imaging for the Diagnosis of Gray Matter Heterotopia
Authors: WILLIAM B. WINCE, ROBERT BURT, DONALD S. SCHAUWECKER, MICHEAL D. PHILLIPS
Journal: Clinical Nuclear Medicine (2003)

WINCE, WILLIAM B.; BURT, ROBERT M.D.; SCHAUWECKER, DONALD S. Ph.D., M.D.; PHILLIPS, MICHEAL D. M.D. Author Information
AMERICAN INDIANS WITH ACUTE CORONARY SYNDROMES PRESENT WITH HIGHER ACUITY BUT HAVE SIMILAR SHORT AND LONG-TERM OUTCOMES AFTER ISOLATED CORONARY ARTERY BYPASS GRAFTING
Authors: Eric Anderson, Matthew Glogoza, Aaron Bettenhausen, Brandon Fisher, Jared Sander, Donald Warne, Cornelius Dyke
Journal: Journal of the American College of Cardiology (2016)
Minimal residual disease (MRD) in remission t(8;21) AML and in vivo differentiation detected by FISH and CD34+ cell sorting
Authors: M Varella-Garcia, CJ Hogan, LF Odom, JL Murata-Collins, H Ai, L Chen, K Richkind, G Paskulin, M Andreeff, A Brizard, L McGavran, RM Gemmill, R Berger, HA Drabkin
Journal: Leukemia (2001)