tbuckley/cabot-search huggingface dataset:
Association of IL-10 and IL-10 Receptor Gene Polymorphisms and Graft-Versus-Host Disease Following Hematopoietic Cell Transplantation.
Authors: Li-Hui Tseng, Ming-Tseh Lin, Barry Storer, Paul J. Martin, Bryan Grogan, Pei-Jer Chen, Lue Ping Zhao, John A. Hansen
Journal: Blood (2004)
SAT0610 The Prospective Risk for Long Term Sickness Absence, Unemployment, and Disability Pension, and The Probability for Return To Work in Patients with Rheumatoid Arthritis:
Authors: S.M. Hansen, M.L. Hetland, J. Pedersen, M. Østergaard, T.S. Rubak, J.B. Bjorner
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Long term sickness absence (LTSA), unemployment and early retirement are some of the most important outcomes of rheumatoid arthritis (RA), both for patient and society. Historically, RA patients have increased risk of LTSA and early disability pension. Modern treatment strategies have improved disease control in the last decades, and a decreased risk of LTSA and disability pension during later years have been reported. It is not known whether this represents a disease-specific decline or if the reduction of disability pension merely reflects a reduction in disability pension in general, due to political, demographic, and socioeconomic changes. <h3>Objectives</h3> To study in a multi-state model 1) the risks of LTSA, unemployment, and disability pension, and the chance of return to work in RA compared to a matched control population and 2) the changes in risks between1994–2011. <h3>Methods</h3> A cohort study of 6,677 RA patients at working age identified in the nationwide DANBIO registry, a register on adult patients with inflammatory joint diseases, and 56,955 matched (age, gender, area of residence) controls from the general population. By linkage with the DREAM registry (a national registry on employment status and sick-leave) and other registries, we analyzed in a multi-state model all shifts between the work-related states simultaneously and calculated hazard rates (HR), stratified by disease duration (early RA (&lt;1yr) and established RA (≥1yr)), controlled for socio-demographic factors, physical job exposure, somatic and psychiatric comorbidities. <h3>Results</h3> The RA patients had increased risk of LTSA (e.g. early RA: HR=4.00) and disability pension (e.g. established RA: HR=2.75) relative to controls, see table. The relative risks of LTSA and disability pension decreased from 1994–99 to 2006–11 (e.g. in established RA: from work to LTSA HR 2.25 to 1.63, and from LTSA to disability pension HR 3.49 to 2.40). Compared to controls, RA patients had a lower chance of returning to work from LTSA (early RA: HR=0.60) or unemployment (early RA: HR=0.77), and this did not change over time. <h3>Conclusions</h3> RA patients remain at high risk for LTSA and disability pension, but a positive trend is seen from 1996–1999 to 2006–2011. Returning to work from unemployment or LTSA remains a challenge for RA patients. <h3>Disclosure of Interest</h3> S. Hansen: None declared, M. Hetland Consultant for: BMS, MSD, Pfizer, Abbott, UCB, Roche, J. Pedersen: None declared, M. Østergaard Consultant for: Abbvie, BMS, Boehringer-Ingelheim, Celgene, Centocor, GSK, Hospira, Eli-Lilly, Janssen, Merck, Mundipharma, Novartis, Novo, Orion, Pfizer, Schering-Plough, Roche, Takeda, UCB, and Wyeth, T. Rubak: None declared, J. Bjorner: None declared
BT062, An Antibody-Drug Conjugate Directed Against CD138, Shows Clinical Activity In a Phase I Study In Patients with Relapsed or Relapsed/Refractory Multiple Myeloma
Authors: Sundar Jagannath, Asher A. Chanan-Khan, Leonard T Heffner, David Avigan, Robert J Lutz, Christoph Uherek, Frank Osterroth, Markus Ruehle, Thomas Haeder, Gabriele Niemann, Andrea Wartenberg-Demand, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood (2010)
Transfusion Dependence and Low Hemoglobin Have the Greatest Impact On Quality of Life (QOL) in MDS Patients - a Tertiary Care Cross Sectional and Longitudinal Study.
Authors: Rena Buckstein, Shabbir Alibhai, Adam Lam, Liying Zhang, Alex Mamedov, Matthew C Cheung, Jeannie Callum, Eugenia Piliotis, Janey Tsiao, Yulia Lin, Richard A. Wells
Journal: Blood (2009)
The Impact of Molecular Lesions in Post-Transplant Acute Myeloid Leukemia (AML) in Correlation with Cytogenetic Abnormalities,
Authors: Nelli Bejanyan, Brian J. Bolwell, Edward A. Copelan, Lisa Rybicki, Hideki Makishima, Andres Jerez, Hirotoshi Sakaguchi, Kathryn M Guinta, Christine L. O'Keefe, Nolyn Nyatanga, Shawnda Tench, Anjali S. Advani, Mikkael A Sekeres, Matt Kalaycio, Eric D. Hsi, Jaroslaw P. Maciejewski
Journal: Blood (2011)
Evolution of Bisphosphonates RELATED Osteonecrosis of the Jaw (BRONJ) IN PATIENTS with MULTIPLE MYELOMA (MM) and WALDENSTROM'S Macroglobulinemia (WM): A Retrospective STUDY.
Authors: Alessandro Andriani, Maria Teresa Petrucci, Tommaso Caravita, Marco Montanaro, Francesco Pisani, Ugo Coppetelli, Marianna De Muro, Velia Bongarzoni, Giuseppe Avvisati, Nicoletta Villivà, Anna Levi, Agostina Siniscalchi, Alessandro Agrillo, Domenico Gaglioti
Journal: Blood (2009)
PTU-017 Per Oral Endoscopic Myotomy (POEM) for Achalasia
Authors: F Chedgy, K Kandiah, S Subramaniam, S Thayalasekaran, G Longcroft-Wheaton, P Bhandari
Journal: Gut (2016)

<h3>Introduction</h3> Achalasia is an oesophageal motor disorder due to inhibitory neuron dysfunction, resulting in loss of oesophageal peristalsis and impaired lower oesophageal sphincter relaxation. POEM is emerging as a viable alternative to laparoscopic Heller’s myotomy (LHM) for the treatment of achalasia. However, it is still in it’s infancy in the West with no reported cases from UK. We aim to present two videos and discuss the technical details of the procedure in a simple type II achalasia and in a complex sigmoid achalasia. <h3>Methods</h3> Prior to undertaking POEM patients are investigated with barium swallow, gastroscopy and high-resolution manometry to confirm the diagnosis of achalasia and delineate the anatomy of the oesophagus. Eckhardt score is calculated pre and post POEM. Informed consent is undertaken, including alternatives to POEM: LHM, pneumatic dilatation and Botox injection. The procedure steps include (video): 1. Submucosal injection and incision 2. Creation of submucosal tunnel 3. Endoscopic myotomy 4. Closure of mucosal entry. <h3>Results</h3> <b>Case 1: </b>A 61 year-old lady, presenting with dysphagia, retrosternal chest pain and regurgitation (Eckhardt score 6). Barium swallow demonstrated typical appearances of achalasia (see video). Pre-POEM manometry confirmed Type II achalasia with a resting lower oesophageal sphincter (LOS) pressure of 26. She underwent an uneventful POEM procedure via the anterior approach using a combination of flush-knife and triangular tip knife to achieve a 10+4 cm myotomy. On follow-up she has no symptoms (Eckhardt score 0) and repeat manometry shows a reduction in LOS pressure to 15. <b>Case 2: </b>A 52 year-old lady, presenting with dysphagia, retrosternal chest pain, regurgitation and weight loss (Eckhardt score 11). Barium swallow demonstrated advanced achalasia with severe dilatation and a sigmoid appearance (see video). She was treated at her local centre with two sessions of PD and one of Botox despite which she suffered ongoing symptoms. Pre-POEM manometry revealed Type II achalasia and an LOS pressure of 25.5. She underwent an uneventful POEM procedure via the posterior approach using the O-type Erbe hybrid knife to achieve an 11 + 4 cm myotomy. Significant fibrosis was encountered due to previous intervention. On follow-up her symptoms improved significantly. Repeat manometry is awaited. <h3>Conclusion</h3> Here we describe the technique of POEM at the two ends of the disease spectrum of achalasia We demonstrate the feasibility of the technique in the hands of a UK Endoscopist. We demonstrate two different approaches to POEMS (Anterior vs Posterior) and with two different knives and will discuss the Pros and Cons of these approaches. Despite previous intervention and submucosal fibrosis, POEM is still a viable treatment for patients with ongoing symptoms. <h3>Disclosure of Interest</h3> None Declared
Cotransfection of Dendritic Cells with RNA Coding for a Tumor Antigen and Costimulatory Molecule 4-1BBL Increases the Induction of Her-2/neu Specific Cytotoxic T-Cells.
Authors: Frank Grünebach, Katrin Kayser, Silke Appel, Markus M. Weck, Martin R. Müller, Volker L. Reichardt, Peter Brossart
Journal: Blood (2004)
Volume of White Matter Hyperintensities Predicts Neurocognitive Functioning in Children with Sickle Cell Disease
Authors: Veronica Van Der Land, Channa T. Hijmans, Marieke A. de Ruiter, Henri J.M.M. Mutsaerts, Marjon H. Cnossen, Charles B.L.M. Majoie, Aart J. Nederveen, Martha A. Grootenhuis, Karin Fijnvandraat
Journal: Blood (2014)
A Gene Expression Classifier for Improved Risk Classification and Outcome Prediction in Pediatric Acute Lymphoblastic Leukemia (ALL).
Authors: Cheryl L. Willman, Huining Kang, Jeffrey W. Potter, Richard C. Harvey, Susan R. Atlas, Ed Bedrick, Paul Helman, Robert L. Veroff, I.-Ming Chen, Andrew J. Carroll, Kerem Ar, Yuexian Xu, Sharon B. Murphy, Deepa Bhojwani, Naomi Moskowitz, William L. Carroll, Bruce Camitta
Journal: Blood (2005)
SP0180 Advances in The Genetics of Chronic Pain Syndromes: How Twin Studies Help
Authors: F.M. Williams
Journal: Annals of the Rheumatic Diseases (2016)

Chronic widespread musculoskeletal pain and fibromyalgia are increasingly viewed as spectrum disorders, and they co-exist with many other pain syndromes within individuals and their families. Large scale epidemiological studies are superior to clinical collections for providing evidence of overlap in the chronic pain syndromes and allowing the genetic and environmental risk factors to be determined. Twin registers are a special case of this and allow many different types of study, which provide answers to important questions in chronic pain. In this talk I will introduce the following concepts:- 1. The chronic pain syndromes 2. The concept of heritability 3. TwinsUK – an NIHR BioResource at KCL 4. Twin study designs which help shed light on chronic pain mechanisms <h3>Disclosure of Interest</h3> None declared
Genetic Polymorphisms In Genes Involved In R-CHOP Metabolism and Event-Free and Overall Survival In Diffuse Large B-Cell Lymphoma
Authors: James R Cerhan, Thomas M Habermann, Matthew J Maurer, James E Wooldridge, Stephen M Ansell, Grzegorz S. Nowakowski, Ivana N Micallef, Carrie A Thompson, Alice H Wang, William R Macon, Sergei I Syrbu, Susan L Slager, Thomas E Witzig, Brian Link
Journal: Blood (2010)
A Phase II Randomized Dose-Ranging Study of the JAK2-Selective Inhibitor SAR302503 in Patients with Intermediate-2 or High-Risk Primary Myelofibrosis (MF), Post-Polycythemia Vera (PV) MF, or Post-Essential Thrombocythemia (ET) MF.
Authors: Moshe Talpaz, Catriona Jamieson, Nashat Y Gabrail, Claudia Lebedinsky, Guozhi Gao, Feng Liu, Ayalew Tefferi, Animesh Pardanani
Journal: Blood (2012)
SAT0560 Automated Ifa Methods Compare Well with Established Manual IFA Screening and Titration for ANA HEp-2
Authors: J. Blecken, T. Matthias, A. Frey, M. Daves, A. Joos, S. Platzgummer
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Often, only basic nuclear patterns, like homogenous, speckled, nucleolar, centromere or cytoplasmic, are reported by laboratories. The detection of other patterns requires well trained readers. As a result, different systems have been developed which automate part of or the complete IFA method and reading process. <h3>Objectives</h3> This study compares 2 commercially available HEp-2 antinuclear antibody (ANA) indirect fluorescent antibody (IFA) assays using a sensitivity panel (120 clinically determined patients) and a specificity panel consisting of 80 clinically confirmed negative patients. <h3>Methods</h3> We compared two different automated systems (A and B) to assess their capability for screening and titration of these samples. The automated method was directly compared to manual reading of the same processed slides on respective microscopes and also compared with the known clinical information. <h3>Results</h3> The results of the two automated methods were in good agreement. System A detected 188 samples correctly from negative and positive samples, versus 187 samples detected by the system B. The falsely detected positive samples were all of low titer (1:80). System A found 157 and System B 156 patterns in agreement to the target pattern. From 80 negative samples system A detected 73 and system B 71 samples correctly. <h3>Conclusions</h3> Both systems resulted in an overall sensitivity &gt;95% and a specificity of 91.25% and 88.75%. The pattern recognition also showed only minor aberrant findings resulting in a slightly better detection of cytoplasmic and nuclear membrane patterns by system A while system B detected slightly better the centromeric pattern. <h3>Disclosure of Interest</h3> None declared
Antileukemic Activity and Tolerability of ASP2215 80mg and Greater in FLT3 Mutation-Positive Subjects with Relapsed or Refractory Acute Myeloid Leukemia: Results from a Phase 1/2, Open-Label, Dose-Escalation/Dose-Response Study
Authors: Jessica K. Altman, Alexander E. Perl, Jorge E. Cortes, Mark J. Levis, Catherine C. Smith, Mark R Litzow, Maria R. Baer, David F. Claxton, Harry P. Erba, Stanley C. Gill, Stuart L. Goldberg, Joseph G. Jurcic, Richard A. Larson, Charles Lui, Ellen K Ritchie, Briana Sargent, Gary J Schiller, Alexander I. Spira, Stephen A. Strickland, Raoul Tibes, Celalettin Ustun, Eunice S. Wang, Robert K. Stuart, Claudia D. Baldus, Christoph Rollig, Andreas Neubauer, Giovanni Martinelli, Erkut Bahceci
Journal: Blood (2015)
CD8 Coreceptor-Independent T Cell Stimulation Induces High Avidity CTL In the Presence of IL-21
Authors: Osamu Imataki, Sascha Ansén, Makito Tanaka, Marcus O. Butler, Alla Berezovskaya, Kiyotaka Kuzushima, Lee M. Nadler, Naoto Hirano
Journal: Blood (2010)
PWE-111 Colonic Wall Thickening at Computed Tomography: Does It Warrant an Endoscopy?
Authors: M Kathawala, SC Cooper
Journal: Gut (2016)

<h3>Introduction</h3> Colonic wall thickening is commonly seen on computed tomography (CT).<sup>1,2</sup> The clinical significance is usually unknown and in the absence of guidance, clinicians often face a dilemma to investigate further and send patients to endoscopy. This retrospective study aims to evaluate what proportion of colonic wall thickening at CT correlated to pathology after endoscopic evaluation and to determine if colonic wall thickening at CT always warrants a lower GI endoscopy. <h3>Methods</h3> A retrospective review of all CT scan reports was performed from 2011 to 2014 at University Hospitals Birmingham NHS Trusts. The database was searched for CT reports which included colonic or bowel wall thickening. Patients with underlying diseases explaining bowel wall thickening were excluded. After selection of relevant cases, anonymised data was collected for gender, age, indication, CT findings and final diagnosis after lower GI endoscopy and biopsy. <h3>Results</h3> In total, 116 patients with colonic wall thickening reported at CT were found. Chiefly, this was limited to one segment of the colon in 96 patients (82.8%), mostly left sided (59.5%, 69/116). The primary reason for requesting a CT scan was to investigate abdominal pain (48.3%, 56/116). Of the patients with colonic wall thickening at CT, only 51.7% (60/116) proceeded onto lower GI endoscopy with diverticular disease (25%, 15/60) as the main pathology and adenocarcinoma in 9% (5/60). A normal endoscopy was found in 39% (23/60). <h3>Conclusion</h3> CT scans will often identify colonic wall thickening (2). Subsequent endoscopic examination was performed in just over 50% of patients with a pathological yield of 61.7%. We recommend endoscopic evaluation where colonic wall thickening is demonstrated at CT for patients without existing diagnosis. <h3>References</h3> 1 Macari M, Balthazar EJ. CT of bowel wall thickening: significance and pitfalls of interpretation. <i>Am J Roentgenol</i> 2001;176:<b>5</b>:1105–1116. 2 Desai RK, Tagliabue JR, Wegryn SA, Einstein DM. CT evaluation of wall thickening in alimentary tract. <i>Radiographics</i>. 1991 Sep;<b>11</b>(5):771–83. <h3>Disclosure of Interest</h3> None Declared
In Vivo Genome Editing of Liver Albumin for Therapeutic Gene Expression: Rescue of Hemophilic Mice Via Integration of Factor 9
Authors: Xavier M Anguela, Rajiv Sharma, Yannick Doyon, Sunnie Y Wong, David E Paschon, Hojun Li, Virginia Haurigot, Robert J Davidson, Shangzhen Zhou, Philip D. Gregory, Michael C. Holmes, Edward Rebar, Katherine A. High
Journal: Blood (2012)
Autologous Stem Cells as Backup for Patients Undergoing Allogeneic Related Transplant for Thalassemia Major.
Authors: Mammen Chandy, Uday Deotare, Chidambaram S, Kavitha M Lakshmi, Vikram Mathews, Biju George, Auro Vishwabandhya, Rajashekar T, Alok Srivastava
Journal: Blood (2009)
Thymic Carcinoma Management Patterns among International Thymic Malignancy Interest Group (ITMIG) Physicians with Consensus from the Thymic Carcinoma Working Group
Authors: Annemarie Shepherd, Gregory Riely, Frank Detterbeck, Charles B. Simone, Usman Ahmad, James Huang, Robert Korst, Arun Rajan, Andreas Rimner
Journal: Journal of Thoracic Oncology (2016)
Impact of Early Post-Transplant Complications on Survival of Patients with Myelodysplastic Syndrome Undergoing Allo-SCT Following Reduced Intensity Conditioning: An SFGM-TC Study
Authors: Alexis Caulier, Jordan Gauthier, Marie Robin, Patrice Chevalier, Yves Beguin, Hélène Labussière-Wallet, Stephane Vigouroux, Jean-Yves Cahn, Stéphanie Nguyen, Felipe Suarez, Anne Huynh, Norbert Ifrah, Mohamad Mohty, Eric Deconinck, Gandhi Damaj, Ibrahim Yakoub-Agha
Journal: Blood (2015)
Comparison of PB CD34+ vs Hematopoietic Progenitor Cell Counts as Predictors of Successful PBPC Collections in Healthy Donors and Patients.
Authors: Isabel L. Barbosa, Carla Carvalho, Maria J. Pires, Elsa Moreira, Sergio M. Lopes, Susana Roncon, Teresa Sousa, Carlos Mendes, Pedro Pimentel, Alzira Carvalhais
Journal: Blood (2007)
PTH-032 Knife Assisted Resection of Right-Sided Colonic Polyps: The Right Way Round!: Abstract PTH-032 Table 1
Authors: K Kandiah, S Thayalasekaran, FJQ Chedgy, S Subramaniam, R Bhattacharyya, P Bhandari
Journal: Gut (2016)

<h3>Introduction</h3> Endoscopic resection of right-sided colonic polyps carries a higher risk of complications including bleeding and perforation. This risk is heightened in the resection of polyps that are tethered, flat or on background of colitis (complex polyps). In the West, complex polyps in the right colon are frequently managed by endoscopic mucosal resection (EMR) or surgery although recurrence rates can be as high as 20%. Endoscopic submucosal dissection (ESD) is an effective technique in the resection of complex polyps. However, ESD is technically challenging with a long learning curve and carries a significant perforation rate (6% in Eastern series and 17% in Western series) leading to a poor uptake of this technique in the West.<sup>[i]</sup>We aim to examine the safety and efficacy of a novel technique of knife assisted snare resection (KAR) in resecting complex polyps in the right colon. <h3>Methods</h3> Data of all KARs undertaken by a single endoscopist in our institution from 2009 to 2015 were prospectively compiled in a pre-designed database and interrogated by independent researchers blinded to the technique. Polyps in the right colon (distal transverse to caecum) were included in the analysis. Polyp characteristics and procedure details were prospectively recorded. Endoscopic follow-up was performed to identify recurrence. <h3>Results</h3> A total of 52 patients with complex polyps 10–80 mm in size were resected by KAR. The mean follow up time was 35 months. 42% of the polyps were &gt;40 mm in size, and 51% were scarred from previous attempts. The majority of the polyps resected (91%) exhibited flat morphology (Paris Classification IIa, IIa+IIb, IIa+IIc). Table 1 shows the patient baseline and lesion characteristics. There were 2 cases of delayed bleeding (4%) neither of which required surgery. The endoscopic cure rate was 96% after single procedure, improving to 98% with further attempts. <h3>Conclusion</h3> This is the first reported Western series of KAR of complex polyps in the right colon. Our data demonstrates that this novel technique is safe and effective for resection of complex polyps in the right colon. The recurrence rates are superior to EMR and complication rates are lower than ESD. As the learning curve for KAR is shorter than that for ESD, we believe that this technique is ideal for the Western setting. <h3>Reference</h3> 1 Saito Y, Uraoka T, Yamaguchi Y, <i>et al</i>. A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections. <i>Gastrointest Endosc</i>. 2010;<b>72</b>:1217–1225 <h3>Disclosure of Interest</h3> None Declared
Adipocytes and Aplastic Anemia: Peroxisome Proliferator-Activated Receptor-γ (PPAR- γ) Antagonists Attenuate Bone Marrow Failure in an Aplastic Anemia Mouse Model but Not in Radiation Marrow Destruction
Authors: Kazuya Sato, Xingmin Feng, Jichun Chen, Marie J. Desierto, Keyvan Keyvanfar, Daniela Malide, Sachiko Kajigaya, Neal S. Young
Journal: Blood (2012)
CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma
Authors: Xin Wang, Liping Li, Yuanzhong Wu, Ruhua Zhang, Meifang Zhang, Dan Liao, Gang Wang, Ge Qin, Rui-hua Xu, Tiebang Kang
Journal: Cancer Research (2016)

Abstract Polycomb chromobox (CBX) proteins participate in the polycomb repressive complex (PRC1) that mediates epigenetic gene silencing and endows PRC1 with distinct oncogenic or tumor suppressor functions in a cell-type–dependent manner. In this study, we report that inhibition of cell migration, invasion, and metastasis in colorectal carcinoma requires CBX4-mediated repression of Runx2, a key transcription factor that promotes colorectal carcinoma metastasis. CBX4 inversely correlated with Runx2 expression in colorectal carcinoma tissues, and the combination of high CBX4 expression and low Runx2 expression significantly correlated with overall survival, more so than either CBX4 or Runx2 expression alone. Mechanistically, CBX4 maintained recruited histone deacetylase 3 (HDAC3) to the Runx2 promoter, which maintained a deacetylated histone H3K27 state to suppress Runx2 expression. This function of CBX4 was dependent on its interaction with HDAC3, but not on its SUMO E3 ligase, its chromodomain, or the PRC1 complex. Disrupting the CBX4–HDAC3 interaction abolished Runx2 inhibition as well as the inhibition of cell migration and invasion. Collectively, our data show that CBX4 may act as a tumor suppressor in colorectal carcinoma, and strategies that stabilize the interaction of CBX4 with HDAC3 may benefit the colorectal carcinoma patients with metastases. Cancer Res; 76(24); 7277–89. ©2016 AACR.