AB1474-HPR Effect of vitamin E on immunity and inflammation in adults with active rheumatoid arthritis (RA)
Authors: N. Aryaeian, F. Shahram, M. Djalali
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Little information on the effects of <i>Vitamin E</i> on inflammation and immune function in humans is available so we decided to investigate the effect of <i>Vitamin E</i> on this autoimmune disease, as our knowledge for the first time. <h3>Objectives</h3> This study investigated the effects of Vitamin E on the inflammatory mediators and Immunity factors in adults with active RA <h3>Methods</h3> In a randomized, double-blind, placebo controlled clinical trial 43 RA patients were randomly divided into 2 groups, each group receiving one of the following daily supplement for 3 months; Group E: 400 mg Vitamin E, Group P: placebo. Cytokines, Citrolinated Antibody (CCP-A)were measured by Elisa method, Vitamin E measured by HPLC. <h3>Results</h3> After study there were no significant differences between groups in cytokines IL2, IL4, TNFα, IL1β, Il2/IL4, CCP-A, WBC and Neutrophils, Lymphocyte, Monocytes, Eeosinophils numbers.TNFα decreased in 2 groups nonsignificantly, but its reduction was more in group E. IL1β increased in both groups P and E (P=0.004, P=0.041 respectively). IL4 decreased in groups E and P (P=0.07, P=0.068 respectively). ESR, CRP, DAS 28 and GPA decreased in group E (P≤0.05). <h3>Conclusions</h3> Vitamin E probably can be useful in RA patients. <h3>References</h3> Venkatraman J, Meksawan K(2002) Effects of dietary omega3 and omega6 lipids and vitamin E on chemokine levels in autoimmune-prone MRL/MpJ-lpr/lpr mice. J Nutr Biochem 13(8), 479. Comstock GW, Burke AE, Hoffman SC, Helzlsouer KJ, Bendich A, Masi AT, Norkus EP, Malamet RL, Gershwin ME(1997) Serum Concentration of alpha tocopherol and carotene and retinol perceding the diagnosis of rheumatoid arthitis and systemic lupus erythmatus. Ann Rheum Dis 56, 323- 5. Edmonds SE, Winyard PG, Gue R, et al.(1997) Putative analgesic activity of repeated oral doses of vitamin E in the treatment of rheumatoid arthritis, Results of a prospective placebo controlled double blind trial. Ann Rheum Dis 56, 649-55. Tidow -Kebritchi S, Mobarhan S (2001). Effects of diets containing fish oil and vitamin E on rheumatoid arthritis. Nutr Rev 59(10), 335-8. Wittenborg A, Petersen G, Lorkowski G, Brabant T(1998) Effectiveness of vitamin E in comparison with diclofenac sodium in treatment of patients with chronic polyarthritis. ZRheumatol 57(4), 215-21. J van Tits L, Demacker P N, Graaf Jde, Lemmers H LH, Anton F (2000)α-Tocopherol supplementation decreases production of superoxide and cytokines by leukocytes ex vivo in both normolipidemic and hypertriglyceridemic individuals. Am J Clin Nutr 71, 458–64. Pallest EG, Schoten EG, Dewaart FG, Fonk HC, Doekes G (1999) Effect 50 and 100 mg vitamin E supplements on Cellular immune function in noninstitutionalized elderly person.American Journal of Clinical Nutrition 69(6),1273-81. Beharka AA, Wu D, Serafini M, Meydani SN(2002) Mechanism of Vitamin E inhibition of Cyclooxygenase activity in macrophages of old mice role of peroxynitrite. Free Radic Biol Med 15, 32(6), 503-11. <h3>Disclosure of Interest</h3> None Declared