tbuckley/cabot-search huggingface dataset:
Endoscopic closure of a gastropleural fistula
Authors: Antonio Mendoza Ladd, Ihsan Al-Bayati, Paresh Shah, Gregory Haber
Journal: Endoscopy (2015)

A 25-year-old woman underwent a sleeve gastrectomy for morbid obesity. Over the next 6 weeks, she was hospitalized three times for recurrent pneumonia. She presented to our hospital with the same problem 8 weeks after the surgery. Computed tomography of the chest showed consolidation of the left lower lobe and a left-sided pleural effusion ([Fig. 1]).
SP0031 The EUMUSC.NET Project
Authors: L. C. Carmona
Journal: Annals of the Rheumatic Diseases (2013)

<h3></h3> The overall aim of eumusc.net was to improve musculoskeletal health through evidence-based policy recommendations for the implementation of a Community strategy and by highlighting good practice so that it could be replicated across Europe. It is 3 years since work began on the eumusc.net project and in a month after Eular Congress the project will be completed. Over the 3 years since it began eumusc has produced the first European agreed patient focused Standards of care for RA and OA and tools to ensure their application with equity across Europe. Other important outcomes are advocacy tools to assess and monitor the improvement of health services for people with RA and OA across Europe. In addition, eumusc has agreed on indicators to ensure that health providers are meeting the needs of people with RA and OA and delivering care to the agreed standard, and has studied the barriers and facilitators to achieving these standards to enable the effective and equitable prevention and management of these conditions in the Member States. <h3>Disclosure of Interest</h3> None Declared
Consumer Group Report Examines Mammography Standards
Authors: N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Consumer Group Report Examines Mammography Standards Get access Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 16, 21 August 1991, Pages 1138–1140, https://doi.org/10.1093/jnci/83.16.1138 Published: 21 August 1991
PTU-165 Endoscopic response of oesophageal carcinoma to neo-adjuvant chemotherapy and survival post-oesophagectomy
Authors: A M Jones, J Cornish, D Chan, G Clark
Journal: Gut (2012)

Introduction Endoscopy and biopsy is an essential initial investigation in oesophageal carcinoma. At our unit a repeat endoscopy is conducted after a patient has completed neo-adjuvant chemotherapy and prior to proceeding to oesophagectomy, predominantly to obtain anatomical information. This study aims to determine whether prognostic information can be derived from the response to chemotherapy. Methods Data were retrospectively collected for patients who had undergone oesophagectomy following neo-adjuvant chemotherapy under a single surgeon over a 10-year period. At endoscopy after chemotherapy, it was noted whether the tumour had made a complete response, a partial response or no response at all, according to length, circumferential involvement and degree of stenosis. Survival data were obtained and compared between groups. Results 72 patients (60 Male, 12 Female) were identified. 25 patients had no response to neo-adjuvant chemotherapy as assessed endoscopically and had a median survival of 27 months and 2-year survival of 38%. 39 patients showed a partial response endoscopically and had a median survival of 30 months and a 2-year survival of 40%. For the eight patients who had a complete response median survival was 57 months and 2-year survival of 68%. Conclusion The response to neo-adjuvant chemotherapy as assessed endoscopically is predictive of post-operative prognosis. A larger study is required to determine if endoscopic assessment could be used to select patients unlikely to benefit from surgery. Competing interests None declared.
Tips for a Physician in Getting the Right Job, Part XVIII
Authors: Jay A. Harolds
Journal: Clinical Nuclear Medicine (2014)

If the candidate for a job is rejected, the individual should not necessarily be discouraged. It may be that the position was particularly competitive or that there were factors beyond the control of the applicant. However, it is important that the candidate carefully considers all aspects of the application and interview process for that position to see if anything could be learned from the process. If the applicant is not successful in being given a job offer for multiple positions, then there must be a careful analysis of the reasons. It could be caused by training, communication issues, a competitive job market-especially in that location, a problematic job record, and so on. If the job seeker is given an offer of employment, it is important to carefully consider all aspects of the offer and consider respectful, professional negotiations on some items.
DOES PREOPERATIVE CARDIOVASCULAR DISEASE INFLUENCE POSTOPERATIVE RESOLUTION OF CARDIOVASCULAR RISK FACTORS AFTER BARIATRIC SURGERY?
Authors: Lindsey Voller, Sayantan Deb, Kaci Dudley, Wes Turner, Michaela Derby, Zachary Ichter, Dan Azagury, John Morton
Journal: Journal of the American College of Cardiology (2016)
Recombinant Erythropoietin for the Treatment of Anemia in Inflammatory Bowel Disease
Authors: Stefan Schreiber, Stefanie Howaldt, Mareille Schnoor, Susanna Nikolaus, Jürgen Bauditz, Christoph Gasché, Herbert Lochs, Andreas Raedler
Journal: New England Journal of Medicine (1996)

Some patients with inflammatory bowel disease have anemia that is refractory to treatment with iron and vitamins. We examined whether administering iron and recombinant erythropoietin could raise hemoglobin levels in such patients.
Severe gastric ischemia after combined sclerotherapy for bleeding gastric ulcer
Authors: J. Molina-Infante, M. Fernandez-Bermejo, G. Vinagre-Rodríguez
Journal: Endoscopy (2011)

The choice of type of additional endoscopic therapy after epinephrine injection for bleeding peptic ulcers should be carefully individualized according to the characteristics of the ulcer.
PWE-146 Biliary invasion in colorectal liver metastasis—does it matter?
Authors: S K P John, S Rehman, B Harrison, S Robinson, B Haugk, D Manas, S White
Journal: Gut (2012)

<h3>Introduction</h3> Vascular invasion of colorectal liver metastasis following liver resection has a detrimental effect on patient outcome. However there are few studies specifically looking at the significance of biliary invasion in colorectal liver metastasis (CRLM). The aim of this study was therefore to evaluate the presence of biliary invasion and patient outcomes in those having liver resection for CRLM. <h3>Methods</h3> All patients having liver resection for colorectal liver metastasis during an 11-year period up to 2011 were identified from a prospectively maintained database. The unit follows standardised pathological reporting for CRLM where biliary and vascular invasion are assessed and documented. Missing information was specifically crosschecked with a separate histopathology database. Univariate and subsequent multivariate analysis were carried out for biliary and vascular invasion individually and in combination with other prognostic variables to assess their clinical significance. Survival was assessed using Kaplan–Meier plots and log rank tests for significance (p&lt;0.05) using SPSS V.19. <h3>Results</h3> 432 patients (67% male, mean age 64.5 years, range 29–86) underwent liver resection for CRLM during this time period. Primary tumours were either colonic (54%) or rectal (46%). Seventy patients (16.3%) had positive biliary invasion on tumour histopathology whereas 137 (32%) had vascular invasion. Overall 155 (36%) patients had both biliary and vascular invasion (BVI). Overall 5-year survival was 43% in this series. On univariate analysis 5-year survival in those patients with biliary invasion was 39.9% compared to 42.5% in those without biliary invasion (p=0.866). Results were similar in those patients with or without vascular invasion respectively (40.4% vs 43.2%, p=0.65). Also combined BVI failed to influence OS (39.2% vs 42.2%, p=0.856). <h3>Conclusion</h3> In our series, bilary invasion of CRLM does not affect overall survival rates in patients having liver resection. <h3>Competing interests</h3> None declared.
Proximal migration of pancreatic stent: placement of smaller stent within another stent for retrieval
Authors: N. Choudhary, R. Puri, R. Sud
Journal: Endoscopy (2014)

A 22-year-old man presented with obstructive jaundice. His workup revealed cholelithiasis and obstruction of the lower end of the common bile duct (CBD) by a stone. He underwent endoscopic retrograde cholangiopancreatography (ERCP) elsewhere; the CBD was cleared, and a 7-Fr pancreatic stent was placed to prevent pancreatitis arising from repeated pancreatic duct cannulation. The pancreatic stent was found to have migrated proximally at 1 week and the patient was referred to us. Pancreatic imaging showed the stent deep in the pancreatic duct (distal to the genu) ([Fig. 1]). Stent retrieval was attempted with a biliary stone extractor balloon, foreign body forceps, basket and snare, however, the stent could not be retrieved. A guidewire was placed through the stent and a 5-Fr stent was placed within it, with the distal end in the duodenal lumen ([Fig. 2]). At a repeat attempt at endoscopic retrieval after 3 days, the smaller stent was pulled out with a snare and the initial, displaced stent came out along with the smaller stent.
P13.22 * CYBERKNIFE STEREOTACTIC RADIOSURGERY FOR THE RE-IRRADIATION OF BRAIN LESIONS: A SINGLE-CENTRE EXPERIENCE
Authors: D. Greto, P. Bonomo, B. Detti, S. Scoccianti, S. Cipressi, S. Cassani, I. Giacomelli, S. Cappelli, D. Franceschini, L. Livi
Journal: Neuro-Oncology (2014)

PURPOSE: The aim of our study was to retrospectively evaluate the feasibility and clinical benefit of cyberknife stereotactic radiosurgery (CSRS) in patients treated at Florence University for recurrent, pre-irradiated brain lesions. MATERIALS AND METHODS: Thirteen patients were retreated with cyberknife. Mean age was 47.1 years (range 33–77 years). Karnofsky Performance Status ranged from 60 to 100 (median 80). Eleven (84.6 %) out of 13 patients had metastatic lesions: four (36.4 %) had primary lung, three (27.2 %) had primary breast cancer and four (36.4 %) other types of solid malignancies. Two (15.4 %) out of 13 patients had recurrent of glioblastoma. RESULTS: In terms of compliance with CSRS, the majority of patients did not develop any acute side effects. However, two (15.4 %) out of 13 patients developed acute grade 2 toxicity requiring an increase of steroid medication. At the time of the last follow-up, response rates were as follows: complete response in one case (16.6 %), partial response in three (50 %) and stable disease in two (33.4 %). CONCLUSIONS: Re-irradiation with CSRS is a feasible and effective option for pre-irradiated, recurrent brain lesions to obtain clinical benefit without excessive acute toxicity.
AB0464 Biologic therapy in aortitis: a multicenter study of 30 patients
Authors: J. Loricera, R. Blanco, S. Castañeda, A. Umbría, S. Melchor, E. Rubio, J. Calvo-Alen, E. Aurrecoechea, I. Rúa-Figueroa, N. Ortego, M. Minguez, G. Herrero-Beaumont, B. Bravo, J. Rosas, J. Narvaez, J. Calvo, R. Ariza, M. Freire, P. Lluch, C. Moll, E. Peiró, V. Calvo-Río, F. Ortiz-Sanjuán, M. González-Gay
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Aortitis is the inflammation of the aortic wall, regardless of the underlying condition. It can occur alone or associated with other causes. Aortitis is often refractory to standard immunosuppressive therapy. <h3>Objectives</h3> To assess the efficacy and side-effects of biological therapy in patients with inflammatory aortitis. <h3>Methods</h3> Multicenter study of 30 patients diagnosed of inflammatory aortitis due to different underlying conditions. The diagnosis of aortitis was based on imaging (CT angiography, MR angiography, PET or echocardiogram). <h3>Results</h3> We studied 30 patients (27women/3men); mean age±SD, 47.07±18.62 years. The underlying etiologies were: Takayasu arteritis (TKY) (16 cases), giant cell arteritis (GCA) (7), relapsing polychondritis (2), sarcoidosis (1), ulcerative colitis (1), Sjögren's syndrome (1), Behcet's syndrome (1) and idiopathic aortitis (1) (Table). In 3 of 30 patients, biological therapy had to be discontinued: 1 GCA with tocilizumab (TCZ) because of neutropenia, 1 GCA with infliximab (IFX) for infusional reactions and 1 TKY with IFX for recurrent pneumonia. Of the remaining 27 patients undergoing biologic therapy, 13 were receiving TCZ (6 TKY, 5 GCA, 1 relapsing polychondritis and 1 idiopathic aortitis), 11 IFX (7 TKY, 2 GCA, 1 Behcet's syndrome, and 1 relapsing polychondritis), 2 were receiving etanercept (2 TKY), 2 rituximab (1 TKY and 1 Sjögren's syndrome) and 2 adalimumab therapy (1 ulcerative colitis and 1 sarcoidosis). Switching from a biologic therapy to another occurred in 8 cases. It was due to inefficacy in 7 cases and allergic reaction in 1 case. After a median [interquartile 25-75] follow-up of 16 [11-24] months most patients experienced clinical improvement and a reduction of ESR levels (from 42.6±29.4 mm/1<sup>st</sup> h to 14.8±14.6 mm/1<sup>st</sup> h). This fact made possible a reduction in the dose of corticosteroids (prednisone: 25.8±20.5 mg/day to 4.6±3.9 mg/day). <h3>Conclusions</h3> Our results indicate that biological therapy seems to be an effective and safe therapeutic option in inflammatory aortitis refractory to conventional immunosuppressive therapy. <h3>Disclosure of Interest</h3> None Declared
Accidental Cannulation of a Femoral Central Venous Catheter Into the Iliolumbar Vein
Authors: Koichiro Shinoda, Hirofumi Taki, Hiroyuki Hounoki, Reina Tsuda, Kazuyuki Tobe
Journal: Clinical Nuclear Medicine (2014)

Central venous catheterization at the femoral site is associated with higher complication rates of infections and thrombosis than at the jugular or subclavian sites. However, the procedure of insertion at the femoral site is considered safer. We present a unique but dangerous positioning of a left femoral central venous catheter into the iliolumbar vein. We were aware of this accidental cannulation by chance when our patient underwent bone scintigraphy. Although a few cases were reported about accidental cannulation into the ascending lumbar vein, this is the first case where a femoral central venous catheter was misplaced into the iliolumbar vein.
Gallo Retires From NIH to Launch New Research Facility
Authors: P. Newman
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Gallo Retires From NIH to Launch New Research Facility Get access Patricia Newman Patricia Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 21, 1 November 1995, Pages 1580–1582, https://doi.org/10.1093/jnci/87.21.1580 Published: 01 November 1995
Colonoscopy, inflammatory bowel disease
Authors: Helmut Neumann, Markus Neurath
Journal: Endoscopy (2014)

Endoscopy Essentials Reviews in the Endoscopy Essentials series cite publications from the past year which, in the authors’ opinion, reflect the state-of-the-art in endoscopy. Alongside a short summary of each paper, authors explain why they consider their selected articles to be of importance.
Abstract 2921: NAD(P)H quinone oxidoreductase 1 regulates pro-inflammatory mediators associated with prostate tumorigenesis.
Authors: Dinesh Thapa, Addanki P. Kumar, Rita Ghosh
Journal: Cancer Research (2013)

Abstract Oxidative stress and inflammation are both important in the neoplastic transformation of the prostate. NAD(P)H Quinone Oxidoreductase 1 (NQO1) is a key antioxidant enzyme that protects against quinone-derived reactive intermediates and maintains a cellular pool of antioxidants. Various studies conducted using NQO1 knockout mice suggested its potential role in carcinogenesis. However the role of NQO1 has not been fully explored in prostate cancer. Here we show that NQO1 silencing by a specific shRNA (shNQO1) increased cell survival, proliferation, colony formation, migration and hormone-independent survival in hormone-responsive human prostate cancer cells LNCaP. Genome wide array revealed that NQO1 blockade significantly upregulated pro-inflammatory mediators (e.g., IL-32, CCL2, IL-8, IL-17C, IL-10RA, CXCR2, CXCR7, NOS3) associated with prostate tumorigenesis. Cytokine profiling further confirmed the increased IL-8 production in conditioned-media from NQO1 knockdown cells compared to the parental cells. However, enforced expression of NQO1 in these cells did not alter IL-8 and other inflammatory mediators. Our data indicate that inflammatory mediators produced by NQO1 knockdown LNCaP cells may be responsible for the hormone-independent survival. Since these inflammatory mediators influence prostate cancer development and castration resistance, strategies modulating cellular antioxidants to regulate NQO1 and other important players in NQO1-signaling may provide multifaceted opportunities for prostate cancer prevention. Supported by a postdoctoral fellowship from CPRIT (DT) and RO1 CA 149516 (RG). Citation Format: Dinesh Thapa, Addanki P. Kumar, Rita Ghosh. NAD(P)H quinone oxidoreductase 1 regulates pro-inflammatory mediators associated with prostate tumorigenesis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2921. doi:10.1158/1538-7445.AM2013-2921
F-18 Fluorodeoxyglucose Positron Emission Tomography Imaging in Ectopic Nonfunctioning Glucagonoma
Authors: S Yasuda, A Shohtsu, K Tomioka
Journal: Clinical Nuclear Medicine (1998)

A 54-year-old woman underwent ultrasonography as a follow-up for type B hepatitis. The study revealed a hypodense and hyperdense mass with a smooth surface touching the lateral segment of the liver and located in front of the portal vein. Although its border with the duodenum was clear, its border with the pancreas head was obscure. CT scan also showed a mass in the inferior aspect of the liver. F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) revealed an accumulation corresponding to the mass, which was suspected to be a malignancy. At surgery, a tumor measuring 5 × 3.6 × 3 cm was found in the hepatoduodenal ligament; it was found to be an ectopic nonfunctioning glucagonoma with a low degree of malignancy.
SAT0425 Serum Autoantibody Profiling in Rheumatic Diseases by Nucleid Acid Programmable Protein Arrays
Authors: L. Lourido, J. Fernandez-Tajes, V. Calamia, C. Fernández, B. Rocha, M. Fuentes, F.J. Blanco, C. Ruiz-Romero
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Osteoarthritis (OA) is characterized by the loss of structural components from the extracelullar matrix (ECM) of articular cartilage. The progressive release of proteins from the tissue and an abnormal metabolic activity can be specifically detected by the immune system, leading to a humoral immune response producing immunoglobulins against these proteins (autoantibodies). Autoantibodies are stable circulating proteins, easily measurable in serum, and may be the signature before clinical manifestations of the disease. Protein microarrays have emerged providing a tool for the identification of disease immunosignatures. <h3>Objectives</h3> The aim of this study was to detect the presence of autoantibodies in OA serum samples and compare these results with those obtained from healthy (CTRL) and rheumatoid arthritis (RA) sera. <h3>Methods</h3> Antibodies were detected using an specific Nucleic Acid Protein Programmable Array (NAPPA) designed and constructed as previously described by Ramachandran et al. 2008, containing 80 sequence-verified full-length human genes obtained from the Center for Personalized Diagnostics at the Arizona State University (www.dnasu.org). Once protein was displayed by <i>in situ</i> protein expression system, NAPPA arrays were incubated in optimized conditions with 20 OA, 20 RA and 18 CTRL serum samples. The autoantibodies were detected by anti-human IgG-HRP and fluorescence dye. Array images were obtained and processed by Genepix4000B and GenePix Software 6.0. For data analysis, background correction was performed by subtraction of the first quartile of non-DNA spots intensity and then divided the excess intensity by the median of spots without DNA across arrays. <h3>Results</h3> Significantly (p&lt;0.05) 4 different expression of autoantibodies against four different proteins has been observed between OA and CTRL serum samples. Of note, 2 of these proteins are related to the metabolism of ECM; the others are associated to cell adhesion (1) and bone mineralization (1). Most interestingly, this approach allowed the differential classification of RA and OA patients by the detection of 3 specific autoantibodies against proteins involved in cell proliferation and bone mineralization processes; one of these proteins also distinguishing between CTRL and RA subjects. <h3>Conclusions</h3> We have identified the presence of specific autoantibodies in OA allowing to distinguish between OA and CTRL patients and most interestingly, between OA and RA patients. These autoantibodies released to the serum might have a biomarker value to more accurate early diagnosis and prognosis of OA patients in clinical routine. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5015