tbuckley/cabot-search huggingface dataset:
PTU-091 Multimatrix mesalazine in paediatric ulcerative colitis: a pharmacokinetic and safety study
Authors: C Cuffari, D Pierce, B Korczowski, K Fyderek, H Van Heusen, S Hossack, P Martin
Journal: Gut (2015)

<h3>Introduction</h3> Data on mesalazine (5-aminosalicylic acid; 5-ASA) use in cases of paediatric ulcerative colitis (UC) are limited. In this phase 1, randomised, open-label, multicentre study (NCT01130844), pharmacokinetic (PK) and safety profiles of 5-ASA and metabolite acetyl-5-ASA (Ac-5-ASA) were examined in youth with UC diagnoses after once-daily (QD) multimatrix mesalazine administration. <h3>Method</h3> Upon enrolment, patients (pts; aged 5–17 y with diagnosis of UC ≥3 mo, stratified by body weight) were given 30, 60, or 100 mg/kg multimatrix mesalazine QD for 1 wk. The existing, approved, 1200 mg tablet was supplemented with newly developed, smaller-sized 300 and 600 mg multimatrix mesalazine tablets in order to achieve the appropriate study doses in children. Mesalazine was administered at home (Days 1–4) and at the clinic (Days 5–7); onsite, safety evaluations were performed, and blood and urine samples obtained for PK analyses. A validated LC/MS/MS assay was used to determine plasma and urine concentrations of 5-ASA and Ac-5-ASA. Key PK parameters assessed included maximum concentration (C<sub>max, ss</sub>), time of C<sub>max, ss </sub>(t<sub>max</sub>), area under the curve for 1 dose interval (AUC<sub>ss</sub>), renal clearance (CL<sub>R</sub>), and% dose absorbed. <h3>Results</h3> In total, 52 pts (21, 22, and 9 pts at 30, 60, and 100 mg/kg, respectively) were randomised and treated. Mean (standard deviation) age was 13.3 (3.1) y, and median (range) time since UC diagnosis was 1.8 (0.2–9.6) y. By Day 5, 5-ASA and Ac-5-ASA plasma concentrations reached steady state for all dose groups. On Day 7, for both 5-ASA and Ac-5-ASA, mean C<sub>max, ss </sub>and AUC<sub>ss</sub>showed dose proportional increases from 30 to 60 mg/kg cohorts. Mean% 5-ASA absorbed for 30, 60, and 100 mg/kg doses were 29.4%, 27.0%, and 22.1%, respectively. Mean CL<sub>R </sub>ranges were 5.0–6.5 L/h for 5-ASA and 10.0–16.2 L/h for Ac-5-ASA. Treatment-emergent adverse events (TEAEs) were reported by 19.2% of pts; no new safety signals were identified. Events were similar among age and dose groups, and no TEAEs led to premature discontinuation. <h3>Conclusion</h3> The PK profiles of 5-ASA and Ac-5-ASA in children and adolescents with UC receiving multimatrix mesalazine across all dose levels were similar to those from historical adult data with respect to absorption, clearance, and intersubject variability. Overall, multimatrix mesalazine was well tolerated with no new safety concerns identified. <h3>Disclosure of interest</h3> C. Cuffari Consultant for: Shire, Prometheus, Abbott Nutrition, D. Pierce Shareholder of: Shire, GlaxoSmithKline, Employee of: Former employee of Shire, B. Korczowski Grant/Research Support from: Shire, K. Fyderek Grant/ Research Support from: Shire, H. Van Heusen Shareholder of: Shire, Employee of: Shire, S. Hossack Employee of: Covance, which received funding from Shire, P. Martin Shareholder of: Shire, Employee of: Shire.
Germany: everyone is insured for long term care
Authors: Annette Tuffs
Journal: BMJ (2002)

Since 1 January 1995 every German citizen has to be insured against the risk of needing special care as a consequence of either disease or old age. About 1.7% of people's wages is deducted every month for this type of insurance, together with a contribution for their health insurance.

Even those with private insurance are obliged to join the nursing care insurance scheme of their insurance company.

The insurance was set up in the mid-1990s because it was recognised that people did not make enough provision for their old age, and the state or private savings would be increasingly stretched by a growing need for nursing care.

People apply to their insurance provider when financial support is needed and extensive care is required for more than six months. An expert team evaluates the level of care needed. There are three levels of care, which, depending on the severity of the disability, range from about €600 (£390; $580) a month, up to €2600.

The money can be used for professional help at home, a place in a nursing home, or as a payment for relatives or other private carers.

The quality of the nursing homes still remains a problem, however, as the German parliament stated in May 2002. But the politicians are equally united in the opinion that no more money can go into the system.
Miscellany
Authors: Thomas F. Maher
Journal: New England Journal of Medicine (1954)

When catastrophe strikes the role of the physician in disaster operations is vital. Civil defense is the preparation for and the carrying out of emergency functions for the purpose of minimizing and repairing injury and damage resulting from disasters caused by attack, sabotage or other hostile action or by fire, flood, earthquake or other natural causes. Specifically, the role of the medical and health services is briefly summarized for the convenience of the physician as follows:The legislation upon which Civil Defense is based in Massachusetts is Chapter 639, Acts of 1950. Federal, State and Local Civil Defense Authorities have . . .
SP0168 Case 1 Presentation: An Elder Patient with Intensive Pain in Both Arms
Authors: A. Sulli
Journal: Annals of the Rheumatic Diseases (2015)

Polymyalgia rheumatica (PMR) is an acute musculoskeletal inflammatory disease of ageing people, characterized by clinical symptoms that may create some difficulties in the differential diagnosis with elderly onset RA (EORA) [1]. Furthermore, 20% of PMR patients develop overt RA during the follow-up, and EORA may present with a PMR-like onset [2]. Common symptoms of PMR may be aching and stiffness in the shoulder and in the pelvic girdles, less frequently arthritis of hands and wrists (23% of cases) [3]. The occurrence of peripheral arthritis may create some difficulties in the differential diagnosis between PMR and EORA, even if rheumatoid factor or anti-citrullinated peptide positivity, symmetrical involvement of wrist, metacarpophalangeal and interphalangeal joints, development of joint erosions and extra-articular manifestations help to differentiate EORA from PMR [3,4]. Treatment response may also help, as PMR usually responds rapidly and better to glucocorticoids than EORA, and has a favourable prognosis [5]. Imaging plays an important role in the comprehensive evaluation of PMR, including its diagnosis and follow-up, allowing appreciation of bursitis, synovitis, soft tissue inflammation and vasculitis [6]. Moreover, imaging patterns of PMR inflammation could help in the diagnostic process and in differential diagnosis with other disease like EORA [3,6]. Different, cytokine, hormonal, inflammatory milieux have been also described in these two clinical conditions [4,5,7,8], and classification criteria have been recently provided for PMR [9]. The clinical case of a seventy-one year old male patient, admitting with pain, stiffness and articular limitation in shoulder and pelvic girdles along with increased inflammatory indexes, will be presented and discussed. Partial response to corticosteroids and progressive improvement until remission after methotrexate administration contributed to confirm the final diagnosis. <h3>References</h3> Pease CT, Haugeberg G, Morgan AW, et al. J Rheumatol 2005; 32:1852–7. Caporali R, Montecucco C, Epis O, et al. Ann Rheum Dis 2001; 60:1021–4. Pease C, Haugeberg G, Montague B et al. Rheumatology 2009; 48:123–7. Cutolo M, Cimmino MA, Sulli A. Rheumatology (Oxford). 2009; 48:93-5. Sulli A, Montecucco CM, Caporali R et al. Ann N Y Acad Sci 2006;1069:307–14. Camellino D, Cimmino MA. Rheumatology (Oxford) 2012; 51:77-86. Cutolo M, Montecucco CM, Cavagna L, et al. Ann Rheum Dis 2006; 65:1438–43. Cutolo M, Sulli A, Pizzorni C, et al. Ann NY Acad Sci 2002; 966:91-6. Dasgupta B, Cimmino MA, Maradit-Kremers H, et al. Ann Rheum Dis 2012; 71:484-92. <h3>Disclosure of Interest</h3> None declared
On Magic in Medicine
Authors: Lewis Thomas
Journal: New England Journal of Medicine (1978)

MEDICINE has always been under pressure to provide public explanations for the diseases with which it deals, and the formulation of comprehensive, unifying theories has been the most ancient and willing preoccupation of the profession. In the earliest days, hostile spirits needing exorcism were the principal pathogens, and the shaman's duty was simply the development of improved technics for incantation. Later on, especially in the Western world, the idea that the distribution of body fluids among various organs determined the course of all illnesses took hold, and we were in for centuries of bleeding, cupping, sweating and purging in efforts . . .
PWE-430 Quality of irritable bowel syndrome information on the internet
Authors: J El-Sheikha, D Crossman, E Hayes, S Ramcharan
Journal: Gut (2015)

<h3>Introduction</h3> To measure the search demand for websites with Irritable Bowel Syndrome (IBS) information and to review the quality of the typical search results returned. <h3>Method</h3> Between January 2009 and December 2014 the Google search engine was used to provide search trend analysis and the top 10 search results of each year. Websites were critically reviewed using the Minervation (LIDA) healthcare website tool. Website accessibility, usability, reliability and overall quality were recorded. Six countries, the USA, UK, Canada, Ireland, Australia, New Zealand and South Africa were studied. <h3>Results</h3> The mean (s.d.) search demand for online information about IBS has increased significantly from 51.6 (12.7) in 2009 to 65.8 (19.5) in 2014 (r²=0.064 P &lt; 0.001). The USA, UK, Australia, New Zealand and Ireland all showed a significant increase, whereas demand in South Africa actually fell. The vast majority of websites were commercial healthcare information portals (n = 109, 26%) medicinal or product advertisements (n = 88, 21.0%) or healthcare professional advertisements (n = 80, 19.0%). Website quality was variable. Overall the USA and UK had the best online healthcare resources available, whereas most other counties were low quality and dominated by commercial advertisements. <h3>Conclusion</h3> Online demand for healthcare information about IBS is increasing, however, a significant number of online healthcare resources are unreliable and of poor quality. Islands of high quality information do exist but they are often very academic in nature. <h3>Disclosure of interest</h3> None Declared.
PTH-291 Open colorectal resection, major post-operative complications and high asa classification are associated with low reversal of ileostomy rates
Authors: M Oliveira Cunha, MI Aslam, S Chaudhri
Journal: Gut (2015)

<h3>Introduction</h3> Formation of defunctioning loop ileostomy after left hemicolectomy and anterior resection for colorectal cancer is a standard practice. Reversal of ileostomy is intended to be performed within 18 months after initial resection. However, this is not always feasible. This study aimed to evaluate closure rates according to ASA classification, Clavien-Dindo classification for surgical complications, laparoscopic and open surgery and age. <h3>Method</h3> A prospectively maintained colorectal cancer database (January 2008 to December 2011) at University Hospitals of Leicester NHS Trust was analysed. The study population included all consecutive patients undergoing elective cancer resection where a defunctioning ileostomy was created. Length of time between cancer resection and closure of ileostomy was calculated. <h3>Results</h3> 335 patients who underwent colorectal surgery with formation of defunctioning ileostomy were identified. Overall our closure of ileostomy rate was 69.2% for whole cohort, but 47.2% for patients aged above 80 years old. Median time between bowel resection and closure of ileostomy was 20.8 months (range 4.5 to 60 months). Patients that underwent open colorectal resection, aged above 80, developed major complications (Clavien-Dindo grade III and IV) post colorectal resection or patients with ASA III and IV had a lower rate of closure of ileostomy rate (p = 0.023, P &lt; 0.01, p = 0.041 and p = 0.014 respectively). <h3>Conclusion</h3> This study shows that patients that underwent open colorectal surgery, aged above 80 years old, with ASA grade III-IV or developed Clavien-Dindo grades III and IV had lower closure of ileostomy rates. Consideration for end colostomy should be given for patients aged above 80 in pre-operative setting. <h3>Disclosure of interest</h3> None Declared.
Cancer Morbidity in Miyagi Prefecture, Japan, and a Comparison with Morbidity in the United States
Authors: Segi, M., Fukushima, I., Fujisaku, S., Kurihara, M., Saito, S., Asano, K., Nagaike, H., Noye, Y., Kamoi, M.
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Cancer Morbidity in Miyagi Prefecture, Japan, and a Comparison with Morbidity in the United States Get access M. Segi, M. Segi Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Fukushima, I. Fukushima Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Fujisaku, S. Fujisaku Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Kurihara, M. Kurihara Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar S. Saito, S. Saito Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar K. Asano, K. Asano Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Nagaike, H. Nagaike Department of Public Health, Faculty of Medicine, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Y. Noye, Y. Noye Department of Health, Miyagi Prefecture, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar M. Kamoi M. Kamoi Department of Health, Miyagi Prefecture, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 3, March 1957, Pages 373–383, https://doi.org/10.1093/jnci/18.3.373 Published: 01 March 1957 Article history Received: 13 July 1956 Published: 01 March 1957
RECOMBINANT α2-INTERFERON TREATMENT IN CHILDREN WITH CHRONIC HEPATITIS B
Authors: Faustino La Banda, MercedesRuiz Moreno, Vincente Carreño, Javier Bartolome, Julia Gutiez, SantiagoRamon Y Cajal, Alberto Moreno, Ignacio Mora, JuanCarlos Porres
Journal: The Lancet (1988)
The Duty to Care in a Pandemic
Authors: Ross Upshur
Journal: The American Journal of Bioethics (2008)

Click to increase image sizeClick to decrease image size Contributors to the University of Toronto Joint Centre for Bioethics Pandemic Ethics Working Group: A. M. Viens, Angus Dawson, Cecile Bensimon, Chris McDougall, Karen Faith, Kumanan Wilson, Shawn Tracy, Alison Thompson, Jennifer Gibson, Jason Nie, Lydia Kapiriri, Ann Robertson, Paul Ritvo, and Ross Upshur.
P2-130: Podoplanin expression in cancerous stroma is a poor prognostic marker- Tissue Microarray Analysis
Authors: Haruhisa Kitano, Keiiku Sen, Naoko Kumagai, Yuta Sakai, Tomonori Tanaka, Tomoya Kono, Hajime Kubo, Junya Fukuoka
Journal: Journal of Thoracic Oncology (2007)
AB0817 Prevalence of Musculoskeletal Complaints and Psoriatic Arthritis in Primary Care Patients with Psoriasis
Authors: M. Karreman, A. Weel, M. van der Ven, M. Vis, I. Tchetverikov, M. Wakkee, T. Nijsten, J. Hazes, J. Luime
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Over 25% of the new consultations in primary care is due to musculoskeletal complaints (MSC)(1). In patient with psoriasis, the underlying diagnosis could be psoriatic arthritis (PsA). Prevalence figures of PsA in psoriasis patients vary widely (6-42%) and data in primary care is scarce (2, 3) <h3>Objectives</h3> To estimate the prevalence of MSC and PsA in primary care patients with psoriasis. <h3>Methods</h3> We conducted a cross-sectional study in adult primary care patients with psoriasis. Patients were identified from GP records by ICPC code S91 for psoriasis. Responding patients reporting pain in joints, entheses or the lower back were checked on eligibility by a telephone interview and invited for clinical evaluation. Ultrasonoghraphy (US) of the enthesis was performed if a patient had at least one tender enthesis (LEI/MASES) by an independent trained examiner. Patients were referred to a rheumatologist if clinical evaluation suggested the presence of arthritis or axial disease or ultrasonography of the enthesis showed positive Power Doppler (PD) signal. A PsA case was defined by opinion of the rheumatologist or fulfilling the CASPAR criteria with PD signal in an enthesis on US. <h3>Results</h3> 2564 psoriasis (PsO) patients from 97 GPs were invited. Of the 1673 responders (65.2%), 841 (50.3%) were willing to participate. 823 (32.1%) patients reported suffering from MSC of which eventually 524 were eligible and clinically evaluated. We identified 81 cases of PsA (Figure 1), of which 17 (21%) were newly diagnosed, leading to a prevalence of 3.2% (95%CI 2.5%&gt;3.9%) among primary care psoriasis patients, assuming no additional cases of PsA among the non-responders. Besides these cases, we also identified 36 patients with enthesitis confirmed by ultrasound, which would increase the prevalence of PsA towards 4.6% (95% CI 3.8%&gt;5.4%). <h3>Conclusions</h3> Among psoriasis patients in primary care the prevalence of PsA is estimated to be 3.2%, which would increase towards 4.6% if you take the enthesitis cases into account. Moreover, 21% of the cases was newly diagnosed. We hereby assumed that no additional cases would be observed in the non-responders. The prevalence of MSC is estimated to be 32.1%, which is comparable with the prevalence in general population (1). <h3>References</h3> van der Linden MW et al., NIVEL/RIVM2004. Ibrahim G. et al, Arthritis Rheum. 2009. Gelfand JM. et al, Arch Dermatol. 2005 <h3>Acknowledgements</h3> This study was financially funded by an investigator-initiated grant from Pfizer bv. <h3>Disclosure of Interest</h3> None declared
Role of dietary polyamines in a phase III clinical trial of DFMO and sulindac for prevention of metachronous colorectal adenomas.
Authors: K. P. Raj, J. A. Zell, C. L. Rock, C. E. McLaren, C. Zoumas-Morse, E. W. Gerner, F. L. Meyskens
Journal: Journal of Clinical Oncology (2010)

1523 Background: Our group has previously demonstrated that polyamine-inhibitory regimen difluoromethylornithine (DFMO) plus sulindac vs. placebo has marked efficacy in preventing metachronous colorectal adenomas in a phase-III trial. Polyamines are synthesized endogenously but also obtained from diet. Here we investigate the role of dietary polyamines in the phase III placebo controlled colorectal adenoma prevention trial with DMFO + sulindac. Methods: Dietary polyamine data were available for 222 of 375 baseline study patients, and for 188 of 267 patients completing the study. A dietary questionnaire completed by each patient was collected at the initiation of the study. Total dietary polyamine content was derived by the sum of dietary putrescine, spermine and spermidine values and further categorized into highest (75%-100%) quartile group vs. a group with lower three quartiles (0-25, 25-50 and 50%-75%). Baseline tissue polyamine concentration was determined using HPLC methodology. Linear and logistic regression analyses were used for risk estimation. Results: A significant direct association was observed between dietary polyamine intake and tissue spermidine (p = 0.02) and spermine concentrations (p = 0.04) at baseline. Higher dietary polyamine group at baseline was associated with adenomas > 1 cm (43.6 % vs. 26.4 %; p = 0.01),high grade adenomas (32.7% vs. 20.4 %; p = 0.06) and advanced adenomas (52.7% vs. 35.9 %; p = 0.02). Among all patients, a significant interaction was observed between treatment, dietary polyamines and the risk of metachronous adenomas (p = 0.01). Therefore we stratified the final analyses (n = 188) by polyamine intake groups. We observed a significant risk reduction of metachronous adenomas from treatment with DFMO+sulindac in the lower dietary polyamine group (RR = 0.19 [0.09-0.40] p < 0.0001) and no benefit in the higher dietary polyamine group (RR = 1.04 [0.32-3.36] p = 0.94). Conclusions: Controlling dietary polyamines may be an effective strategy for preventing the occurrence of colorectal adenomas and colorectal cancer. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Cancer Prevention Pharmaceuticals Cancer Prevention Pharmaceuticals
THE FUTURE OF PARTICLE RADIATION IN MAN
Authors: H P AIDEM, L D BAKER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Using Wearable Video Technology to Build a Point-of-View Surgical Education Library
Authors: H. Randall Beard, Alejandro J. Marquez-Lara, Kamran S. Hamid
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal