tbuckley/cabot-search huggingface dataset:
A Prospective Trial of Radiation Alone vs Combination Chemotherapy Alone for Early-Stage Hodgkin’s Disease: Implications of 25-Year Follow-Up to Current Combined Modality Therapy.
Authors: Dan L. Longo, Eli Glatstein, Patricia L. Duffey, Robert C. Young, Shelby Fiem, Elaine S. Jaffe, Kevin Camphausen, Wyndham Wilson, Vincent T. DeVita
Journal: Blood (2006)
SNP Chip Analysis of Myelodysplastic Syndromes Disclosed High Frequency of Uniparental Disomy and a Novel Dominant Mutation as the Target of 11q UPD.
Authors: Masashi Sanada, Lee-Yung Shih, Takahiro Suzuki, Go Yamamoto, Yasuhito Nannya, Mamiko Y. Sakata, Motohiro Kato, Keiki Kumano, Norihiko Kawamata, Hiraku Mori, Mineo Kurokawa, Shigeru Chiba, Mitsuhiro Omine, Phillip H. Koeffler, Seishi Ogawa
Journal: Blood (2007)
Activation of silent mating type information regulation 2 homolog 1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and inflammation
Authors: Caroline Steinmetz, Anubha Kashyap, Nataliya Zhivkova, Henry Alizor, Isabell Ernst, Daniela Gottfried‐Brand, Henning Janssen, Andreas Teufel, Henning Schulze‐Bergkamen, Johannes Lotz, Jürgen Kuball, Matthias Theobald, Michael Heise, Hauke Lang, Peter R. Galle, Dennis Strand, Susanne Strand
Journal: Hepatology (2017)

Incidence and prevalence of inflammatory liver diseases has increased over the last years, but therapeutic options are limited. Pregnancy induces a state of immune tolerance, which can result in spontaneous improvement of clinical symptoms of certain autoimmune diseases including autoimmune hepatitis (AIH). We investigated the immune‐suppressive mechanisms of the human pregnancy hormone, chorionic gonadotropin (hCG), in the liver. hCG signaling activates silent mating type information regulation 2 homolog 1 (SIRT1), which deacetylates forkhead box o3 (FOXO3a), leading to repression of proapoptotic gene expression, because the immunosuppressive consequence attributed to the absence of caspase‐3 activity of hepatocellular interleukin 16 (IL‐16) is no longer processed and released. Thus, serum levels of IL‐16, a key chemotactic factor for CD4 + lymphocytes, were reduced and migration to injured hepatocytes prevented. Furthermore, elevated IL‐16 levels are found in the sera from patients with AIH, hepatitis B virus, hepatitis C virus, and nonalcoholic steatohepatitis. Conclusion : Here, we report that hCG regulates the SIRT1/FOXO3a axis in hepatocytes, resulting in immune suppression by attenuating caspase‐3–dependent IL‐16 processing and release, which concomitantly prevents autoaggressive T‐cell infiltration of the liver. Considering the low toxicity profile of hCG in humans, interrupting the inflammatory cycle by hCG opens new perspectives for therapeutic intervention of inflammatory liver diseases. (H epatology 2017;65:2074‐2089).
Glucocorticoids modulate human brown adipose tissue thermogenesis in vivo
Authors: Hannah Scotney, Michael E. Symonds, James Law, Helen Budge, Don Sharkey, Konstantinos N. Manolopoulos
Journal: Metabolism (2017)

Brown adipose tissue (BAT) is a thermogenic organ with substantial metabolic capacity and has important roles in the maintenance of body weight and metabolism. Regulation of BAT is primarily mediated through the β-adrenoceptor (β-AR) pathway. The in vivo endocrine regulation of this pathway in humans is unknown. The objective of our study was to assess the in vivo BAT temperature responses to acute glucocorticoid administration.We studied 8 healthy male volunteers, not pre-selected for BAT presence or activity and without prior BAT cold-activation, on two occasions, following an infusion with hydrocortisone (0.2mg.kg-1.min-1 for 14h) and saline, respectively. Infusions were given in a randomized double-blind order. They underwent assessment of supraclavicular BAT temperature using infrared thermography following a mixed meal, and during β-AR stimulation with isoprenaline (25ng.kg fat-free mass-1.min-1 for 60min) in the fasting state.During hydrocortisone infusion, BAT temperature increased both under fasting basal conditions and during β-AR stimulation. We observed a BAT temperature threshold, which was not exceeded despite maximal β-AR activation. We conclude that BAT thermogenesis is present in humans under near-normal conditions. Glucocorticoids modulate BAT function, representing important physiological endocrine regulation of body temperature at times of acute stress.
Diagnostic and Therapeutic Implications of Expression and Phosphorylation of the Translation Regulatory Protein 4E-Binding Protein (BP)-1 in B-Cell Lymphomas and Reactive Lymphoid Tissues.
Authors: Mary J. Ninan, Ajay Rawal, Dhatri Kodali, Hector Mesa, Manish Patel, Dennis Knapp, Robert A Kratzke, Pankaj Gupta
Journal: Blood (2009)
Handball load and shoulder injury rate: a 31-week cohort study of 679 elite youth handball players
Authors: M Møller, R O Nielsen, J Attermann, N Wedderkopp, M Lind, H Sørensen, G Myklebust
Journal: British Journal of Sports Medicine (2017)

Background Knowledge of injury patterns, an essential step towards injury prevention, is lacking in youth handball. Aim To investigate if an increase in handball load is associated with increased shoulder injury rates compared with a minor increase or decrease, and if an association is influenced by scapular control, isometric shoulder strength or glenohumeral range of motion (ROM). Methods 679 players (14–18 years) provided weekly reports on shoulder injury and handball load (training and competition hours) over 31 weeks using the SMS, phone and medical examination system. Handball load in a given week was categorised into (1) &lt;20% increase or decrease (reference), (2) increase between 20% and 60% and (3) increase &gt;60% relative to the weekly average amount of handball load the preceding 4 weeks. Assessment of shoulder isometric rotational and abduction strength, ROM and scapular control was performed at baseline and midseason. Results An increase in handball load by &gt;60% was associated with greater shoulder injury rate (HR 1.91; 95% CI 1.00 to 3.70, p=0.05) compared with the reference group. The effect of an increase in handball load between 20% and 60% was exacerbated among players with reduced external rotational strength (HR 4.0; 95% CI 1.1 to 15.2, p=0.04) or scapular dyskinesis (HR 4.8; 95% CI 1.3 to 18.3, p=0.02). Reduced external rotational strength exacerbated the effect of an increase above 60% (HR 4.2; 95% CI 1.4 to 12.8, p=0.01). Conclusions A large increase in weekly handball load increases the shoulder injury rate in elite youth handball players; particularly, in the presence of reduced external rotational strength or scapular dyskinesis.
STUDIES ON MENINGOCOCCUS INFECTION
Authors: Henry W. Scherp, Geoffrey Rake
Journal: The Journal of Experimental Medicine (1936)

Type I antimeningococcal horse sera have been standardized by the quantitative determination of their type-specific precipitin content. By a method involving dialysis and precipitation by treatment with carbon dioxide, the antibody in such sera has been purified tenfold with respect to the nitrogen content.
Worse Outcomes of Patients With HFE Hemochromatosis With Persistent Increases in Transferrin Saturation During Maintenance Therapy
Authors: Edouard Bardou-Jacquet, Fabrice Lainé, Pascal Guggenbuhl, Jeff Morcet, Caroline Jézéquel, Dominique Guyader, Romain Moirand, Yves Deugnier
Journal: Clinical Gastroenterology and Hepatology (2017)
Adiposity As a Principal Component of Lethal Cytokine Storm Following Cancer Immunotherapy in Aged Mice
Authors: Annie Mirsoian, Myriam N. Bouchlaka, Gail Sckisel, Mingyi Chen, Chien-Chun Steven Pai, Emanuel Maverakis, Richard Spencer, Kenneth Fishbein, Sana Siddiqui, Arta Monjazeb, Bronwen Martin, Stuart Maudsley, Charles Hesdorffer, Luigi Ferrucci, Dan L. Longo, Bruce R. Blazar, Robert Wiltrout, Dennis D Taub, William J Murphy
Journal: Blood (2014)
Antitumor activity of miR-34a in peritoneal mesothelioma relies on c-MET and AXL inhibition: persistent activation of ERK and AKT signaling as a possible cytoprotective mechanism
Authors: Rihan El Bezawy, Michelandrea De Cesare, Marzia Pennati, Marcello Deraco, Paolo Gandellini, Valentina Zuco, Nadia Zaffaroni
Journal: Journal of Hematology & Oncology (2017)

The value of microRNAs (miRNAs) as novel targets for cancer therapy is now widely recognized. However, no information is currently available on the expression/functional role of miRNAs in diffuse malignant peritoneal mesothelioma (DMPM), a rapidly lethal disease, poorly responsive to conventional treatments, for which the development of new therapeutic strategies is urgently needed. Here, we evaluated the expression and biological effects of miR-34a—one of the most widely deregulated miRNAs in cancer and for which a lipid-formulated mimic is already clinically available—in a large cohort of DMPM clinical samples and a unique collection of in house-developed preclinical models, with the aim to assess the potential of a miR-34a-based approach for disease treatment. miR-34a expression was determined by qRT-PCR in 45 DMPM and 7 normal peritoneum specimens as well as in 5 DMPM cell lines. Following transfection with miR-34a mimic, the effects on DMPM cell phenotype, in terms of proliferative potential, apoptotic rate, invasion ability, and cell cycle distribution, were assessed. In addition, three subcutaneous and orthotopic DMPM xenograft models were used to examine the effect of miR-34a on tumorigenicity. The expression of miRNA targets and the activation status of relevant pathways were investigated by western blot. miR-34a was found to be down-regulated in DMPM clinical specimens and cell lines compared to normal peritoneal samples. miR-34a reconstitution in DMPM cells significantly inhibited proliferation and tumorigenicity, induced an apoptotic response, and declined invasion ability, mainly through the down-regulation of c-MET and AXL and the interference with the activation of downstream signaling. Interestingly, a persistent activation of ERK1/2 and AKT in miR-34a-reconstituted cells was found to counteract the antiproliferative and proapoptotic effects of miRNA, yet not affecting its anti-invasive activity. Our preclinical data showing impressive inhibitory effects induced by miR-34a on DMPM cell proliferation, invasion, and growth in immunodeficient mice strongly suggest the potential clinical utility of a miR-34a-replacement therapy for the treatment of such a still incurable disease. On the other hand, we provide the first evidence of a potential cytoprotective/resistance mechanism that may arise towards miRNA-based therapies through the persistent activation of RTK downstream signaling.
The JAK2-V617F Mutant Found in Myeloproliferative Disorders and Acute Myeloid Leukemia Cooperates with the EpoR, but Not with FLT3 To Promote Proliferation of IL-3 Dependent Cells.
Authors: Seshu K. Kaza, Sridhar Vempati, Reindl Carola, Wolfgang Hiddemann, Karsten Spiekermann
Journal: Blood (2006)
Regulatory Action Necessary for Immune Globulin Preparations for Hepatitis A Prophylaxis
Authors: Mitchell H. Katz
Journal: JAMA Internal Medicine (2017)

Alexandra Tejada-Strop, MS; Maria Isabel Costafreda, PhD; Zoya Dimitrova, MS; Gerardo G. Kaplan, PhD; Chong-Gee Teo, MD, PhD
Phase I Study of Flavopiridol in Combination with Imatinib Mesylate (STI571, Gleevec) in Bcr/Abl+ Hematological Malignancies.
Authors: Steven Grant, Judith E. Karp, Omer N. Koc, Brenda Cooper, Selina Luger, William D. Figg, Merrill Egorin, Brian J. Druker, James W. Jacobberger, Viswanathan Ramakrishnan, Edward B. Perkins, A. Dimitrios Colevas, John D. Roberts
Journal: Blood (2005)
Preliminary Evidences of Circulating Inflammatory Markers Associated with Symptom Development In Patients with Multiple Myeloma During Induction Therapy
Authors: Xin Shelley Wang, James M Reuben, Bang-Ning Lee, Robert Z. Orlowski, Valen E Johnson, Jacqueline Joy, Matthew Galland, Evan Cohen, Gary M Mobley, Ping Liu, Tito R Mendoza, Charles Cleeland
Journal: Blood (2010)
Treatment of Higher Risk Myelodysplastic Syndrome Patients Unresponsive to Hypomethylating Agents with ON 01910.Na
Authors: Mahesh Seetharam, Mai Tran, Alice C. Fan, Liwen Xu, John P. Renschler, Dean W. Felsher, Kunju Sridhar, Francois Wilhelm, Peter L. Greenberg
Journal: Blood (2010)
Sickle Erythrocytes Have Increased Adducin Phosphorylation and Increased ROS Production Mediated by Signaling Pathways Involving Protein Kinase C and Rac GTPases.
Authors: Theodosia A. Kalfa, Alex George, Suvarnamala Pushkaran, Xiuli An, Clinton H. Joiner, Narla Mohandas, Yi Zheng
Journal: Blood (2009)
Emerging links between m6A and misregulated mRNA methylation in cancer
Authors: Samie R. Jaffrey, Michael G. Kharas
Journal: Genome Medicine (2017)

N 6-methyladenosine (m6A) in mRNA has emerged as a crucial epitranscriptomic modification that controls cellular differentiation and pluripotency. Recent studies are pointing to a role for the RNA methylation program in cancer self-renewal and cell fate, making this a new and promising therapeutic avenue for investigation.
The Combination of Stem Cell Factor and Oncostatin M Maintains Cord Blood-Derived NOD/SCID-Repopulating Cells.
Authors: Siv Gilfillan, Simone Kraner, Katharina S. Goetze, Matthias Schiemann, Stefanie Marz, Christian Peschel, Robert A.J. Oostendorp
Journal: Blood (2005)
Clinical and Biological Implications of Hepatitis C Virus Positivity in Waldenstrom's Macroglobulinemia Patients.
Authors: Alessandra Tedeschi, Eleonora Vismara, Marzia Varettoni, Antonino Greco, Francesca Ricci, Claudia Maria Basilico, Erika Ravelli, Chiara Rusconi, Michele Nichelatti, Marco Montillo, Mario Lazzarino, Enrica Morra
Journal: Blood (2009)
The Prognostic Impact of Fluorescent-in Situ Hybridization (FISH) and Conventional Karyotying in Korean Multiple Myeloma Patients: A Retrospective Multicenter Study.
Authors: Min Jae Kim, Suk Joong Oh, Chang Ki Min, Chong Won Park, Hwi-Joong Yoon, Young Rok Do, Byung Soo Kim, Yang Soo Kim, Hyeon Seok Eom, Hun-Mo Ryoo, Sung Hyun Kim, Ho Jin Shin, Soo-Mee Bang, Seok Jin Kim, Sung-Soo Yoon, Dong Soon Lee, Cheolwon Suh, Jin Seok Kim, Jong Ho Won, Seongkyu Park, Min Kyoung Kim, Hyeok Shim, Hye Jin Kang, Chul Soo Kim, Je-Jung Lee, Jae-Yong Kwak, Deog Yeon Jo, Jae Hoon Lee
Journal: Blood (2009)
A Phase I-II Dose Escalation Trial of Clofarabine Plus Melphalan and Thiotepa Followed by Unmodified Allogeneic Stem Cell Transplant (SCT) for the Treatment of High Risk or Advanced Acute Leukemia
Authors: Farid Boulad, Nancy A Kernan, Susan E Prockop, Andromachi Scaradavou, Trudy N Small, Elizabeth G Klein, Juliet Barker, Ann A. Jakubowski, Guenther Koehne, Esperanza Papadopoulos, Miguel-Angel Perales, James W. Young, Richard J. O'Reilly
Journal: Blood (2010)
The Cell Polarity PTK7 Receptor Is Expressed in Myeloid Cells and Acts as a Modulator of the Chemotherapeutic Response in AML Patients.
Authors: Thomas Prebet, Anne Catherine Lhoumeau, Christine Arnoulet, Anais Aulas, Sylvie Marchetto, Michael Sebbagh, Benjamin Esterni, Norbert Vey, Jean Paul Borg
Journal: Blood (2009)
The Characterization of DYRK3 mRNA and the Utility of DYRK3 Inhibitors in a Carboplatin/Radiation Mouse Model of Anemia.
Authors: Connie L. Erickson-Miller, Ying Homan, Matthew Chomo, Elizabeth I. Valoret, Louis Elefante, Amy Landis, Antony Chadderton, Christopher B. Hopson
Journal: Blood (2007)
The use of pretest probability increases the value of high-resolution CT in diagnosing usual interstitial pneumonia
Authors: Robert Brownell, Teng Moua, Travis S Henry, Brett M Elicker, Darin White, Eric Vittinghoff, Kirk D Jones, Anatoly Urisman, Carlos Aravena, Kerri A Johannson, Jeffrey A Golden, Talmadge E King, Paul J Wolters, Harold R Collard, Brett Ley
Journal: Thorax (2017)

<h3>Background</h3> Recent studies have suggested that non-definitive patterns on high-resolution CT (HRCT) scan provide sufficient diagnostic specificity to forgo surgical lung biopsy in the diagnosis of idiopathic pulmonary fibrosis (IPF). The objective of this study was to determine test characteristics of non-definitive HRCT patterns for identifying histopathological usual interstitial pneumonia (UIP). <h3>Methods</h3> Patients with biopsy-proven interstitial lung disease (ILD) and non-definitive HRCT scans were identified from two academic ILD centres. Test characteristics for HRCT patterns as predictors of UIP on surgical lung biopsy were derived and validated in independent cohorts. <h3>Results</h3> In the derivation cohort, 64/385 (17%) had possible UIP pattern on HRCT; 321/385 (83%) had inconsistent with UIP pattern. 113/385 (29%) patients had histopathological UIP pattern in the derivation cohort. Possible UIP pattern had a specificity of 91.2% (95% CI 87.2% to 94.3%) and a positive predictive value (PPV) of 62.5% (95% CI 49.5% to 74.3%) for UIP pattern on surgical lung biopsy. The addition of age, sex and total traction bronchiectasis score improved the PPV. Inconsistent with UIP pattern demonstrated poor PPV (22.7%, 95% CI 18.3% to 27.7%). HRCT pattern specificity was nearly identical in the validation cohort (92.7%, 95% CI 82.4% to 98.0%). The substantially higher prevalence of UIP pattern in the validation cohort improved the PPV of HRCT patterns. <h3>Conclusions</h3> A possible UIP pattern on HRCT has high specificity for UIP on surgical lung biopsy, but PPV is highly dependent on underlying prevalence. Adding clinical and radiographic features to possible UIP pattern on HRCT may provide sufficient probability of histopathological UIP across prevalence ranges to change clinical decision-making.
Bodily arousal differentially impacts stimulus processing and memory: Norepinephrine in interoception
Authors: Hugo D. Critchley, Sarah N. Garfinkel
Journal: Behavioral and Brain Sciences (2016)

Abstract Bodily arousal modulates stimulus processing and memory, contributing to expression of emotional salience. The “glutamate amplifies noradrenergic effects” (GANE) model proposed by Mather and colleagues can be extended to account for the differential impact of interoceptive (notably cardiac afferent) signals on sensory processing. However, some emotion-specific effects, for example, for fear, may further depend on functional anatomical organisation of affect-related brain structures.
Pharmacological Inhibition of EGFR Signaling Enhances G-CSF Induced Hematopoietic Stem Cell Mobilization.
Authors: Marnie A. Ryan, Ellen Xing, David Schleimer, Kalpana Nattamai, Deidre Daria, Wei Liu, Michael Jansen, Nancy Ratner, Timothy Le Cras, Gary Van Zant, Yi Zheng, Hartmut Geiger
Journal: Blood (2008)
A lung adenocarcinoma subset associated with non-smokers, micropapillary architecture, distinct transcript profile, and EGFR mutation
Authors: Noriko Motoi, Janos Szoke, Maureen F. Zakowski, William D. Travis, William L. Gerald
Journal: Cancer Research (2006)

Proc Amer Assoc Cancer Res, Volume 47, 2006

4530 

Background: The most common recognized cause of lung cancer is cigarette smoking, however about 15% of patients have never smoked. It is likely that lung cancer molecular subtypes are strongly influenced by the predisposing carcinogenic exposures. Our assumption is that molecular mechanisms contributing to the biology of tumors in non-smokers differ from those of smokers. Material and Methods: 106 primary lung adenocarcinoma were analyzed by transcript profile (Affymetrix U133A), hotspot mutation profile (EGFR, ERBB2, BRAF, KRAS, NTRK3, PI3CA and TP53) and immunohistochemistry for EGFR, HER2, ERBB-3&-4, KIT, p-AKT, p-Erk, ER, PR, Ki67 and caspase3. A subset of cases were further studied by complete sequencing of EGFR, ERBB2, BRAF, AKT, EPHB2, EPHA3, FES2, FGFR2, KDR, KIT, NTRK-1,-2&-3, MET, PTEN, PI3CA, TP53. Histological review was performed and clinical features were recorded. Result: A robust molecular subgroup of 16 cases was identified by unsupervised clustering analysis of transcript profiles. The subgroup showed strong association with never or short smoking history (< 10 pack years), younger age and EGFR mutation. Histologically, the subgroup correlated with presence of papillary and micropapillary component. Deletion or point mutations of EGFR were detected in 11 of 16 cases within this subgroup and only 4 of 90 others (p<0.001). One of 16 had a point mutation of PI3CA and 1 of 16 had TP53 mutation. Mutation of codon 12 or 13 of KRAS was detected in 0 of 16 subgroup cases and 15 of 90 others. Nonsynonymous somatic mutation of the coding region was not detected for any other gene. The subgroup showed correlation with immunohistochemical expression of p-AKT (p=0.023) and TTF1 (p=0.027). Discussion: Our data suggest there is a lung adenocarcinoma molecular subtype that commonly arises in non-smokers and has distinctive clinicopathologic and molecular features. This subgroup has transcript profiles similar to patients with activating mutations of EGFR implicating the EGFR signaling pathway regardless of EGFR status. Our data suggest that there are few genomic mutations in other receptor tyrosine kinase and cancer related genes evaluated. Our initial studies also suggest that these subtypes are associated with distinct pathologic features. Although independent validation is needed, these studies help define a subclass of lung adenocarcinoma for which EGFR mediated signal transduction may be a relevant therapeutic target.
Three-drug chronotherapy via hepatic artery as salvage treatment for patients with liver-only metastases from colorectal cancer
Authors: M. Bouchahda, K. Tanaka, R. Adam, S. Giacchetti, C. Brezault-Bonnet, X. M. Li, D. Gholam, O. Ghémard, C. Jasmin, F. Lévi
Journal: Journal of Clinical Oncology (2005)

3616 Background: Molecular circadian rhythms differ between liver and tumor cells (Filipski et al. Cancer Res 2004). In patients with liver metastases from colorectal cancer, chemotherapy activity with the 3 major drugs could be improved through hepatic artery circadian delivery (HACD). Methods: The therapeutic potential of 3-drug HACD was evaluated in 25 heavily pretreated non hospitalized patients (pts) with metastatic colorectal cancer (MCC). They received 5-day (d) q21 d courses (c) with d1 irinotecan (160 mg/m2 from 2 to 8 a.m. peak at 5 a.m.) and d2–5 oxaliplatin (20 mg/m2/d, from 10 a.m. to 10 p.m., peak at 4 p.m.) and 5-fluorouracil (600 mg/m2/d, from 10 p.m. to 10 a.m., peak at 4 a.m.). 127 courses (c) were given (median, 5; 1–15) using a multichannel pump (Mélodie, Aguettant, F). Toxicity was assessed q21 d and response q3 c with CT scan. Results: Pt characteristics: prior chemotherapy lines 1/2/3/4+: 3/4/7/11 pts; WHO Performance Status 0/1/2/3: 12/8/4/1 pts; median age: 63 years (32–73); liver only: 18 pts; liver and lung: 7 pts. Treatment was withdrawn for thrombosis (4 pts) and/or Grade (gr) 3 abdominal pain (3 pts). Grade 3–4 diarrhea and vomiting respectively occurred in 5 pts (20%) and 4 pts (16%) and were the main toxicities. Leucopenia, anemia and thrombocytopenia were respectively encountered in 3, 2 and 1 pt (<12% of the pts). NCIC grade 3 sensory neuropathy occurred in 2 pts and alopecia in 3 pts. Of 22 pts with measurable lesions, disease progressed in 11 pts (exclusively outside the liver for 3 pts) and was controlled in 11 patients (50%), including 8 objective responses (36.3%). Two responding pts could undergo R0 hepatectomy. Median Progression free survival is 5 months [95% C.L., 2 to 8] and median survival is 19.5 mo [16.6 to 22.3]. Eight pts are alive at 1.5 to 33 mo. Conclusions: Three-drug HACI displayed good tolerability and high antitumor activity against liver metastases despite extensive prior systemic chemotherapy. This local chronotherapy regimen could be combined with systemic molecular targeted therapy to avoid extrahepatic dissemination. No significant financial relationships to disclose.
The MD Anderson Cancer Center (MDACC) Experience with Ruxolitinib, An Oral JAK1 and JAK2 Inhibitor, in Myelofibrosis: Long-Term Follow-up Outcomes of 107 Patients From a Phase I/II Study,
Authors: Srdan Verstovsek, Zeev Estrov, Jorge E. Cortes, Deborah A. Thomas, Gautam Borthakur, Tapan Kadia, Elias Jabbour, Sherry Pierce, Hagop M. Kantarjian
Journal: Blood (2011)