tbuckley/cabot-search huggingface dataset:
Accuracy and Longevity of an Implantable Continuous Glucose Sensor in the PRECISE Study: A 180-Day, Prospective, Multicenter, Pivotal Trial
Authors: Jort Kropff, Pratik Choudhary, Sankalpa Neupane, Katharine Barnard, Steve C. Bain, Christoph Kapitza, Thomas Forst, Manuela Link, Andrew Dehennis, J. Hans DeVries
Journal: Diabetes Care (2016)

It is known that continuous glucose monitoring (CGM) systems can lower mean glucose compared with episodic self-monitoring of blood glucose. Implantable CGM systems may provide additional benefits.We studied the Eversense (Senseonics Inc.) implantable CGM sensor in 71 participants aged 18 years and older with type 1 and type 2 diabetes in a 180-day multinational, multicenter pivotal trial. Participants used the CGM system at home and in the clinic. CGM accuracy was assessed during eight in-clinic visits with the mean absolute relative difference (MARD) for venous reference glucose values >4.2 mmol/L as the primary end point. Secondary end points included Clarke Error Grid Analysis and alarm performance. The primary safety outcome was device-related serious adverse events. This trial is registered with ClinicalTrials.gov, number NCT02154126.The MARD value against reference glucose values >4.2 mmol/L was 11.1% (95% CI 10.5, 11.7). Clarke Error Grid Analysis showed 99.2% of samples in the clinically acceptable error zones A and B. Eighty-one percent of hypoglycemic events were detected by the CGM system within 30 min. No device-related serious adverse events occurred during the study.Our results indicate the safety and accuracy of this new type of implantable CGM system and support it as an alternative for transcutaneous CGM.
William Rimmer Lee
Authors: David Lee
Journal: BMJ (2016)

William Rimmer Lee (“Tim”) was born in Dulwich, London. He attended Alleyn’s School and subsequently entered Guy’s Hospital Medical School on an open science scholarship, graduating in 1945. Through these war years, his extracurricular activities included firewatching at St Paul’s Cathedral. After the war he did his deferred national service in the Royal Air Force on a short service commission with tours to Egypt, and it was here that his passion for industrial medicine was born. On leaving in 1953 he worked in the Midlands as a …
Let local areas raise extra healthcare funding through taxation, report argues
Authors: Gareth Iacobucci
Journal: BMJ (2016)

Thank you for your interest in spreading the word about The BMJ.NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Username * Your Email * Send To * You are going to email the following Let local areas raise extra healthcare funding through taxation, report argues Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Long-Lasting HHV-6 Reactivation and Immune Recovery In Adult Long-Survivors After Umbilical Cord Blood (UCB) Allo-SCT: A Comparison With PBSC As Stem-Cell Source
Authors: Marina Illiaquer, Florent Malard, Thierry Guillaume, Berthe-Marie Imbert-Marcille, Jacques Delaunay, Amandine Le Bourgeois, Marie Rimbert, Céline Bressollette-Bodin, Cristina Precupanu, Pierre Peterlin, Philippe Moreau, Mohamad Mohty, Patrice Chevallier
Journal: Blood (2013)
Limiting Care for Surgical Patients at the End of Life
Authors: William Schecter
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Comparative Evaluation of Hematologic Analyzers Advia® 120, Advia® 2120 and Pentra® 120DX for Platelet Counts below 40 X 109/L.
Authors: Josep M. Jou, Fulgencio Navalon, Ester Jiménez, Maribel Diaz-Ricart, Rosa Brugues, Antonio Ordinas, Gines Escolar
Journal: Blood (2005)
Rituximab-Pecc Induction Followed By 90y-Ibritumomab Tiuxetan Consolidation in Relapsed or Refractory DLBCL Patients Who Are Not Eligible for or Have Failed ASCT: Results from a Phase II HOVON Study
Authors: Pieternella J Lugtenburg, Josée M Zijlstra, Jeanette K Doorduijn, Lara H Böhmer, Marinus van Marwijk Kooy, Mels Hoogendoorn, Henriette W Berenschot, Aart Beeker, Fransje Valster, Harry C. Schouten, Marleen Luten, Henk Hofwegen, Dana A Chitu, Rolf E Brouwer, Gustaaf W van Imhoff
Journal: Blood (2015)
THE VALIDITY OF SESSION RATINGS OF PERCEIVED EXERTION FOR MONITORING TRAINING INTENSITY DURING INDOOR ROWING: A CASE REPORT FROM AN ELITE ATHLETE IN PREPARATION FOR THE WORLD CHAMPIONSHIPS
Authors: SJ McLaren, JH. Howse, M Weston, MD Wright
Journal: British Journal of Sports Medicine (2016)

Session ratings of perceived exertion (sRPE) are a popular tool for monitoring exercise intensity across a range of sports. Despite this, little is known regarding the application of sRPE to rowing ergometry. We therefore aimed to explore the validity of sRPE for monitoring training intensity during indoor rowing training. A thirty-six-year-old, female, indoor rower was monitored over a sixteen-week training period; prior to the British and World Indoor Rowing Championships (2 nd place, 30–39 year heavyweight). Rowing training could be classified as: Maximum Effort Free Stroke Rate (MaxFree; n=37), Maximum Effort Capped Stroke Rate (MaxCapped; n=9), Oxygen Utilisation 1 (UT1; n=13) and 2 (UT2; n=23), or Recovery (n=32). Throughout each training session, heart rate and a range of ergometer-derived measures were monitored continuously. Approximately 30 minutes after each training session, the athlete recorded a global sRPE (arbitrary units; AU) via the centiMax (CR100 ® ) scale. The mean (±SD) sRPE scores for each training mode were: 75±17 for MaxFree, 64±14 for MaxCapped, 50±15 for UT1, 31±9 for UT2 and 28±14 for Recovery. The differences in sRPE between these five training modes ranged from possibly to most likely substantial. Session RPE correlations were most likely very large with mean percentage of maximal heart rate (%HR max ; r=0.83; ±90% confidence limits 0.07), very likely very large with mean 500 m split time (−0.79; ±0.08), likely very large with normalized power output (0.77; ±0.07), and possibly very large with work (kilojoules) per minute (0.72; ±0.08). Regression analysis revealed that 80% of the adjusted variance in sRPE could be explained by the combination of mean %HR max , mean 500 m split time, normalized power output and work per minute (SEE=10 AU); with the strongest predictor variable being mean %HR max (partial r=0.61; ±0.16, likely large). Session RPE are able to discriminate between training modes of different physiological intensities and are associated with a range of objective internal and external measures of intensity during rowing ergometry. These findings provide new evidence to support the use of sRPE as a tool for monitoring and prescribing training with indoor rowing athletes.
High prevalence of smoking related lung diseases in an early lung cancer CT screening program in Hiv-infected subjects
Authors: S. Bommart, I. Bouassida, H. V. Kovacsik, P. Lentz, A. Delemazure, O. Corneloup, S. Poire, P. Brillet, V. Le Moing, J. Reynes, I. Poizot-Martin, Amandine Cournil, A. Makinson
Journal: American Journal of Respiratory and Critical Care Medicine (2015)
Regulating Off-Label Promotion — A Critical Test
Authors: Christopher Robertson, Aaron S. Kesselheim
Journal: New England Journal of Medicine (2016)

Interview with Prof. Christopher Robertson on whether the First Amendment should protect sales pitches by pharmaceutical representatives. (06:56)Download In 2012, a U.S. appeals court ruled that a pharmaceutical sales representative's promotion of off-label uses of a drug was protected commercial speech under the First Amendment. Now a new case will challenge that claim, as the battle over off-label promotion continues.
Estimating Longitudinal Risks and Benefits From Cardiovascular Preventive Therapies Among Medicare Patients: The Million Hearts Longitudinal ASCVD Risk Assessment Tool: A Special Report From the American Heart Association and American College of Cardiology
Authors: Donald M. Lloyd-Jones, Mark D. Huffman, Kunal N. Karmali, Darshak M. Sanghavi, Janet S. Wright, Colleen Pelser, Martha Gulati, Frederick A. Masoudi, David C. Goff
Journal: Circulation (2016)

The Million Hearts Initiative has a goal of preventing 1 million heart attacks and strokes—the leading causes of mortality—through several public health and healthcare strategies by 2017. The American Heart Association and American College of Cardiology support the program. The Cardiovascular Risk Reduction Model was developed by Million Hearts and the Center for Medicare &amp; Medicaid Services as a strategy to assess a value-based payment approach toward reduction in 10-year predicted risk of atherosclerotic cardiovascular disease (ASCVD) by implementing cardiovascular preventive strategies to manage the “ABCS” (aspirin therapy in appropriate patients, blood pressure control, cholesterol management, and smoking cessation). The purpose of this special report is to describe the development and intended use of the Million Hearts Longitudinal ASCVD Risk Assessment Tool. The Million Hearts Tool reinforces and builds on the “2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk” by allowing clinicians to estimate baseline and updated 10-year ASCVD risk estimates for primary prevention patients adhering to the appropriate ABCS over time, alone or in combination. The tool provides updated risk estimates based on evidence from high-quality systematic reviews and meta-analyses of the ABCS therapies. This novel approach to personalized estimation of benefits from risk-reducing therapies in primary prevention may help target therapies to those in whom they will provide the greatest benefit, and serves as the basis for a Center for Medicare &amp; Medicaid Services program designed to evaluate the Million Hearts Cardiovascular Risk Reduction Model.
5-Azacitidine Therapy in Elderly Patients with Acute Myelogenous Leukemia Yields Similar Survival Compared to 3+7 Induction Chemotherapy with Less Transfusional Support, Bacteremias, and Hospital Days.
Authors: Stuart L. Goldberg, Jack W. Hsu, Andrew R. Orr, Scott D. Rowley, Michele L. Donato, Phyllis McKiernan, David S. Siegel, Andre H. Goy, Charles S. Hesdorffer, Andrew L. Pecora
Journal: Blood (2006)
Assessing the Patient With Arthralgia, Fevers, and Rash
Authors: Alexandros Sarantopoulos, Ioannis Gkougkourelas, Panagiota Boura
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
NSCLC, metastatic CheckMate 026: A phase 3 trial of nivolumab vs investigator's choice (IC) of platinum-based doublet chemotherapy (PT-DC) as first-line therapy for stage iv/recurrent programmed death ligand 1 (PD-L1)−positive NSCLC
Authors: M. Socinski, B. Creelan, L. Horn, M. Reck, L. Paz-Ares, M. Steins, E. Felip, M. van den Heuvel, T.E. Ciuleanu, F. Badin, N. Ready, T.J.N. Hiltermann, S. Nair, R. Juergens, S. Peters, E. Minenza, W.J. Geese, P. Bhagavatheeswaran, A. Chen, D.P. Carbone
Journal: Annals of Oncology (2016)
Abstract 159: Empowering Cardiac Progenitor Cell-mediated Repair of Injured Myocardium by Overexpressing P2Y2 Nucleotide Receptor
Authors: Farid El-Sayed, Mark Sussman
Journal: Circulation Research (2015)

Heart failure is a leading cause of death in the US due to the limited capability of adult mammalian heart to regenerate following injury. Autologous stem cell therapy holds promise for regeneration of injured myocardium after myocardial infarction. However, stem cells derived from diseased organs exhibit impaired proliferative and migratory capabilities and increased susceptibility to cell death. Empowering stem cells from diverse origins, including cardiac progenitor cells (CPCs), with pro-survival genes has been attempted. Despite the well-established roles of purinergic signaling mediated by extracellular nucleotides in regulating diverse cellular responses in cardiovascular diseases, it has not been well-defined in CPCs. Our preliminary data show, for the first time, that the majority of P2 purinergic receptors are expressed and exhibit functional responses to ATP and UTP in mouse and human CPCs. Since previous findings have shown that the G protein-coupled P2Y 2 receptor (P2Y 2 R) induces cardioprotective responses in animal models as well as human cardiomyocytes and regulates a wide range of signaling pathways that are crucial to tissue repair in various experimental models and in stem cells from diverse origins, we aim to determine whether P2Y 2 R plays similar roles in CPCs. Our preliminary data show that the P2Y 2 R agonists ATP and UTP enhance human CPC (hCPC) proliferation, migration and survival. Interestingly, hCPCs that exhibit relatively slower growth kinetics and higher levels of senescence markers show a dramatic decrease in P2Y 2 R expression as compared to fast-growing hCPCs consistent with our hypothesis that overexpressing P2Y 2 R participates in rejuvenating hCPCs and improving their growth capabilities. This hypothesis will be tested in vivo by determining whether P2Y 2 R overexpression in hCPCs improves their reparative potential for injured mouse myocardium. We also introduce the novel hypothesis that P2Y 2 R-induced regenerative responses in hCPCs involve the activation of Hippo signaling that is known to be regulated by different GPCRs, which links the extracellular nucleotides released during cardiac ischemia to extracellular matrix sensing and Hippo signaling that have been recently implicated in cardiac regeneration.
Bone Marrow Interaction and Multiple Myeloma - Approximating Reality in Novel High-Throughput Multiple Myeloma Coculture Systems
Authors: Johannes Waldschmidt, Dagmar Wider, Anna Simon, Andreas R. Thomsen, Christine Aldrian, Marie Follo, Julia Schüler, Martin Kortum, Ralph Wäsch, Monika Engelhardt
Journal: Blood (2014)
Two Unusual Lymphomas
Authors: S. Abraksia, P. Dileep Kumar, Jan Kasal
Journal: Journal of Clinical Oncology (2000)

Article Tools DIAGNOSIS IN ONCOLOGY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2000.18.21.3731 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 11054447 Two Unusual Lymphomas Case 1: Primary Malignant Lymphoma (Diffuse Large B-Cell Lymphoma) of the Spleen Mimicking Splenic Abscess S. AbraksiaxS. AbraksiaSearch for articles by this author , P. Dileep KumarxP. Dileep KumarSearch for articles by this author , Jan KasalxJan KasalSearch for articles by this author Show More Huron Hospital, Cleveland, OH https://doi.org/10.1200/JCO.2000.18.21.3731 First Page Full Text PDF Figures and Tables © 2000 by American Society of Clinical Oncology
Methotrexate in Relapsed Childhood Acute Myeloid Leukemia: A Single Agent Therapeutic Window Study.
Authors: Gertjan J. Kaspers, Dirk Reinhardt, Gudrun Fleischhack, Hortensia Armendariz, Batia Stark, Christian M. Zwaan, Martin Zimmermann, Ursula Creutzig
Journal: Blood (2004)
MOVEMENT COMPETENCY AND ASSOCIATION WITH GAME PERFORMANCE IN SECONDARY SCHOOL NETBALL PLAYERS
Authors: K Spencer, C Whatman, D Reid
Journal: British Journal of Sports Medicine (2016)

Game performance (GP) is characterised by a high frequency of jumping &amp; catching to maintain possession &amp; create scoring opportunities. Coaches use Movement Competency (MC) to predict player GP. A cross-sectional observational study collected MC &amp; GP data from 37 players (age 16±1 y, height 180±6 cm, mass 69.6±8.6 kg) to determine if associations existed between MC &amp; GP. Jumping &amp; catching were coded as frequency of successful actions. Landings were coded as symmetrical (SL) or asymmetrical (AL) and stable or unstable. Good performance in sports is thought to be reflected through good MC as the body segments are well aligned which promotes a fluid action &amp; an expected positive association between MC &amp; GP. The mechanism of ‘drop jumps’ (MC score) would be expected to have a relationship with landing &amp; balance strategies (GP measure). Players in end (GA,GS,GD,GK) positions (Mean±SD 178±4 cm) were taller than players in link (WA,WD,C) positions (171±4 cm; t(22)=4.03, p=.001, two-tailed). The magnitude of the differences in the means (MD=7.5, 95% CI: 4 to 11) was very large (eta squared=.42). Players rated with a MC score of 21 across all scores are considered as moderately competent, 58% of the players failed to reach this score. The total MC score (maximum 32) ranged from 15 to 27. Link players jumped more frequently than end players (86% jumped over 5 times compared to 30% respectively; χ2 (1, n =37)=8.5, p =.001, phi=0.54), yet there was no association with jump frequency &amp; the MC measures of jump height, jump power &amp; position. Drop jump right (DJR) had a medium negative correlation with total catches ( r =−.36, n =35, p =.04) with a low angle of DJR associated with lower frequency of total catches &amp; it had a medium negative correlation with AL ( r =−.36, n =35, p =.05) with a low angle of DJR associated with lower frequency of AL. There was a strong negative correlation with frequency of ankle balance strategy ( r =−.51, n =35, p =.002) &amp; a low angle of DJR associated with lower frequency of stability. Poor MC remains an issue in secondary school netball &amp; strategies to improve movement &amp; landing competency should remain a focus of coach &amp; player development. Yet the poor association of MC to GP suggests this is an injury prevention measure, rather than as informative data underpinning talent identification.
The Clinical and Prognostic Influence Of Mutations In The Cohesin Complex In Acute Myeloid Leukemia
Authors: Felicitas Thol, Robin Bollin, Marten Gehlhaar, Carolin Walter, Martin Dugas, Karl Suchanek, Aylin Kirchner, Liu Huang, Anuhar Chaturvedi, Martin Wichmann, Lutz Wiehlmann, Frederik Damm, Gudrun Goehring, Brigitte Schlegelberger, Richard F. Schlenk, Konstanze Döhner, Hartmut Döhner, Jürgen Krauter, Arnold Ganser, Michael Heuser
Journal: Blood (2013)
Rare Inherited Clotting Factor Deficiencies in Paediatric Population Single Tertiary Centre Experience in Saudi Arabia
Authors: Mahasen al Saleh, Tarek Owaidah, Abdulrahman Al Musa, Hazzaa Al-Zahrani, Suleman Al-Sweedan, Nicy Joseph, Rubina Malik, Khawar Siddiqui, Sohaib Zulfiqar, Rafat Jafri
Journal: Blood (2014)
Clofarabine Does Not Impact Negatively the Outcomes of Patients with Acute Myeloid Leukemia (AML) Undergoing Allogeneic Stem Cell Transplantation and Is Not Associated with Higher Liver Toxicity Rates Compared with Standard Chemotherapy
Authors: Michael S Mathisen, Hagop M. Kantarjian, Elias Jabbour, Guillermo Garcia-Manero, Farhad Ravandi, Stefan Faderl, Gautam Borthakur, Jorge E. Cortes, Alfonso Quintas-Cardama
Journal: Blood (2011)
Staphylococcus aureus colonization at ICU admission as a risk factor for developing S. aureus ICU pneumonia
Authors: F.P. Paling, M. Wolkewitz, L.G.M. Bode, P.M.C. Klein Klouwenberg, D.S.Y. Ong, P. Depuydt, L. de Bus, F. Sifakis, M.J.M. Bonten, J.A.J.W. Kluytmans
Journal: Clinical Microbiology and Infection (2016)
Non-Myeloablative Autologous Hematopoietic Stem Cell Transplantation for Systemic Lupus Erythematosus.
Authors: Laisvyde Statkute, Yu Oyama, Ann Traynor, Larissa Verda, Walter G. Barr, Robert Rosa, James Schroeder, Nela Krosnjar, Kathleen Quigley, Kimberly Yaung, Marcelo Villa, Miyuki Takahashi, Richard K. Burt
Journal: Blood (2005)
Early risk and protective factors for problem gambling: A systematic review and meta-analysis of longitudinal studies
Authors: N.A. Dowling, S.S. Merkouris, C.J. Greenwood, E. Oldenhof, J.W. Toumbourou, G.J. Youssef
Journal: Clinical Psychology Review (2016)

This systematic review aimed to identify early risk and protective factors (in childhood, adolescence or young adulthood) longitudinally associated with the subsequent development of gambling problems. A systematic search of peer-reviewed and grey literature from 1990 to 2015 identified 15 studies published in 23 articles. Meta-analyses quantified the effect size of 13 individual risk factors (alcohol use frequency, antisocial behaviours, depression, male gender, cannabis use, illicit drug use, impulsivity, number of gambling activities, problem gambling severity, sensation seeking, tobacco use, violence, undercontrolled temperament), one relationship risk factor (peer antisocial behaviours), one community risk factor (poor academic performance), one individual protective factor (socio-economic status) and two relationship protective factors (parent supervision, social problems). Effect sizes were on average small to medium and sensitivity analyses revealed that the results were generally robust to the quality of methodological approaches of the included articles. These findings highlight the need for global prevention efforts that reduce risk factors and screen young people with high-risk profiles. There is insufficient investigation of protective factors to adequately guide prevention initiatives. Future longitudinal research is required to identify additional risk and protective factors associated with problem gambling, particularly within the relationship, community, and societal levels of the socio-ecological model.
Comparison of the Predictive Value of MRD and PVA Score in Pediatric ALL.
Authors: Anja Troeger, Gabriele Escherich, Udo zur Stadt, M. L Den Boer, Rob Pieters, Martin Zimmermann, Ulrich Göbel, Arndt Borkhardt, Dagmar Dilloo, Gritta Janka
Journal: Blood (2008)