tbuckley/cabot-search huggingface dataset:
Sinusitis
Authors: George F. Reed
Journal: New England Journal of Medicine (1962)

Chronic SinusitisChronic sinusitis is relatively rare now because acute sinus disease is treated more efficiently and, with the aid of antibiotics, more effectively. Nevertheless, chronic sinus disease is still encountered. In most cases treatment is rewarding, and a defeatist attitude is to be condemned. Although it is wise to give the patient an adequate trial of conservative medical treatment such as vasoconstrictors, antibiotics and allergic therapy, by and large the definitive treatment of chronic sinus disease is surgical.Chronic Maxillary SinusitisTreatment of chronic disease of the maxillary antrum has not changed a great deal in recent years for . . .
PWE-239 Developing a patient reported outcome measure for symptom assessment in irritable bowel syndrome by experience sampling methodoutcomeof focus groups
Authors: L Vork, D Keszthelyi, Z Mujagic, D Jonkers, J van Os, C Leue, J Kruimel, A Masclee
Journal: Gut (2015)

<h3>Introduction</h3> There is a growing need to understand the experience of irritable bowel syndrome (IBS) and factors contributing to its disease burden, from the patient–s perspective. Retrospective end-of-day questionnaires are currently used to assess abdominal pain and other gastrointestinal symptoms in IBS. However, these assessments are influenced by recall bias and psychosocial factors. The Experience Sampling Method (ESM) may overcome these limitations by assessing symptoms randomly and repeatedly in the natural state and environment of the subject. An explorative study from our group demonstrated more accurate measurements of IBS symptom patterns when comparing ESM to retrospective questionnaires. Aim of the current study was to develop a short and balanced patient-reported outcome measure for symptom assessment using ESM based on focus group interviews. <h3>Method</h3> Focus group interviews were conducted to obtain patient input in order to develop an ESM questionnaire, to be administered randomly ten times a day. Participants, meeting Rome III criteria for IBS, were asked to suggest every item they considered relevant. Additionally, subjects were instructed to specifically criticise the ESM questionnaire that was used in our previously performed pilot study. After reaching saturation, the identified items were discussed by local experts in the field of neurogastroenterology in order to develop the final ESM questionnaire. <h3>Results</h3> Four focus group meetings were organised with 4–8 participants attending each session (76.5% female; 54 ± 12.6 years). These revealed seven essential categories: abdominal pain, defecation, provoking and relieving factors, dietary factors, other gastrointestinal symptoms, mood and psychological factors, comorbidities and medication use. In total, the participants disclosed 43 specific questions. Experts reduced these to 25 in order to decrease the time and burden associated with completing the questionnaire. <h3>Conclusion</h3> In this study, a patient-reported outcome measure, suitable for symptom assessment, including possible influencing daily life factors in IBS, was developed. This measure is to be validated in a large, heterogeneous IBS population in order to implement it as a symptom assessment tool to evaluate therapeutic responses. Furthermore, ESM offers a suitable approach to identify daily life triggers for symptoms with potential implications for individualised therapeutic strategies. <h3>Disclosure of interest</h3> None Declared.
Cluster of Salmonella Enteritidis in Sweden 2005-2006 – suspected source: almonds
Authors: L Ledet Muller, M Hjertqvist, Lara Payne, H Pettersson, A Olsson, L Plym-Forshell, Y Andersson
Journal: Eurosurveillance (2007)

Previous outbreaks of Salmonella Enteritidis in Canada and the United States have been associated with the consumption of almonds. From December 2005 to August 2006 a cluster of 15 cases of Salmonella Enteritidis NST 3+ was reported in Sweden. A case-control study was performed to identify the source of transmission. Three controls per case were randomly selected, matched on sex, age and place of residence. Cases and controls were interviewed by telephone and data were analysed with a conditional logistic model. The results showed that eating almonds was a risk factor for infection with Salmonella Enteritidis NST3+ (unmatched odds ratio 45.0, 95% confidence interval: 4.8-421.8). No Salmonella was isolated from almonds tested in the study. In conclusion, almonds could be the source of the outbreak and should be considered when investigating outbreaks as well as sporadic cases of Salmonella Enteritidis.
Thiazides and Related Oral Diuretics
Authors: L E FARHI
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Platelet membrane fluidity in Alzheimer's disease and major depression
Authors: G S Zubenko, B M Cohen, C F Reynolds, F Boller, I Malinakova, N Keefe
Journal: American Journal of Psychiatry (1987)

Double-blind fluorescence studies of platelet membrane fluidity were conducted at 37 degrees C for 51 patients with Alzheimer-type dementia, 24 nondemented depressed patients, and 50 neurologically healthy subjects. The fluidity of the hydrocarbon region of platelet membranes from the demented group, as reflected by the steady-state anisotropy of the fluorescent probe 1,6-diphenyl-1,3,5-hexatriene (DPH), was significantly greater than that for the depressed and normal control subjects. Within the demented group, platelet membrane fluidity was significantly correlated with severity of dementia but not with duration of illness or age at onset. Demented patients with "increased" platelet membrane fluidity had an earlier onset, were more severely demented, and deteriorated more rapidly.
SP0158 The Lupus Secrets: Latest Treatment Recommendations
Authors: D.E. Thomas
Journal: Annals of the Rheumatic Diseases (2015)

Systemic lupus erythematosus is a complex disease that is genetic in origin, yet triggered by many events in our environment. Learning to regularly avoid the well-known triggers is an important part in learning to improve disease activity in lupus. Dr. Thomas, author of "The Lupus Encyclopedia: A Comprehensive Guide for Patients and Families" strongly believes that patients should be empowered with knowledge to help improve how their lupus does, live longer, and have a better quality of life. He will share with the audience what he calls "The Lupus Secrets", which is an important list of things that most, if not all, people with lupus should do in order to fight against their disease to the fullest. This list includes what triggers should be avoided and improved upon. It includes important measures to do that can improve the treatments given by doctors, and what to do in order to prevent common complications from lupus (such as infections, heart disease, and cancers). Better medical therapies for lupus are quickly evolving to include recent expert recommendations that should be used world-wide. He will share these recent recommendations, called "Treat-to-Target in Systemic Lupus Erythematosus", with the audience. In Dr. Thomas9 experience, those patients who arm themselves with this information plus put it into effect do better in dealing with their disease than those who do not. Make sure to attend this important talk if you or a loved one has lupus and wish to learn what you can do to combat this horrible disease. <h3>Disclosure of Interest</h3> D. Thomas Paid instructor for: Author of: The Lupus Encyclopedia: A Comprehensive Guide for Patients and Families
Symptoms of posttraumatic stress disorder following recovery of war dead
Authors: J E McCarroll, R J Ursano, C S Fullerton
Journal: American Journal of Psychiatry (1993)

Persons who handled human remains in Operation Desert Storm (N = 116) were compared with those who did not handle remains (N = 118) on symptoms of posttraumatic stress disorder. Subjects who handled remains reported more intrusive and avoidant symptoms than other subjects. Subjects who were inexperienced at handling remains had more symptoms than those who were experienced. Within the experienced group, there was a significant correlation between the number of remains handled and level of symptoms reported.
Coordinated Growth of Body Parts and Cancer&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Harold F. Blum
Journal: JNCI Journal of the National Cancer Institute (1959)

The application of the principle of coordinated growth to the interpretation of studies of carcinogenesis is discussed. It is pointed out that since a cancer may be considered as a growing part of its host it should be influenced by factors that affect the over-all growth of the host. This lends a degree of uncertainty to the interpretation of cancer studies in which either the time-to-appearance of cancer or the incidence of cancer in a population of animals, at a given time, is used as an index of carcinogenicity, therapeutic action on cancer, the action of endocrines, etc.
Preoperative oral immunonutrition versus standard preoperative oral diet in well nourished patients undergoing pancreaticoduodenectomy
Authors: S. Silvestri, A. Franchello, G. Deiro, R. Galletti, D. Cassine, D. Campra, D. Bonfanti, L. De Carli, F. Fop, G.R. Fronda
Journal: International Journal of Surgery (2016)
To notify or not to notify: decision aid for policy makers on whether to make an infectious disease mandatorily notifiable
Authors: Paul Bijkerk, Ewout B. Fanoy, Katina Kardamanidis, Simone M. van der Plas, Margreet J. te Wierik, Mirjam E. Kretzschmar, George B. Haringhuizen, Hans J. van Vliet, Marianne A. van der Sande
Journal: Eurosurveillance (2015)

Mandatory notification can be a useful tool to support infectious disease prevention and control. Guidelines are needed to help policymakers decide whether mandatory notification of an infectious disease is appropriate. We developed a decision aid, based on a range of criteria previously used in the Netherlands or in other regions to help decide whether to make a disease notifiable. Criteria were categorised as being effective, feasible and necessary with regard to the relevance of mandatory notification. Expert panels piloted the decision aid. Here we illustrate its use for three diseases ( Vibrio vulnificus infection , chronic Q fever and dengue fever) for which mandatory notification was requested. For dengue fever, the expert panel advised mandatory notification; for V. vulnificus infection and chronic Q fever, the expert panel concluded that mandatory notification was not (yet) justified. Use of the decision aid led to a structured, transparent decision making process and a thorough assessment of the advantages and disadvantages of mandatory notification of these diseases. It also helped identify knowledge gaps that required further research before a decision could be made. We therefore recommend use of this aid for public health policy making.
PTU-020 Diagnosing small bowel crohn’s disease – using capsule when the imaging is negative
Authors: A Coombs, U Chelvaratnam, A Terlevich, P Marden
Journal: Gut (2015)

<h3>Introduction</h3> The European Crohn’s and Colitis Organisation guidelines<sup>1</sup>state that small bowel capsule endoscopy (SBCE) should be reserved for patients in whom the clinical suspicion for Crohn’s disease remains high despite negative evaluations with ileocolonoscopy and radiological examinations. SBCE has been shown to detect a higher yield of non-stricturing small bowel Crohn’s disease compared to CT and small bowel barium radiology<sup>2</sup>and improved detection rates compared with MRI.<sup>3</sup>Southmead Hospital is a tertiary referral centre for SBCE which receives referrals throughout the Somerset region. We assessed the diagnostic yield from patients referred for CE for suspected Crohn’s Disease. <h3>Method</h3> All patients referred for SBCE to assess for small bowel Crohn’s disease between May 2013 and May 2014 were identified. Patients with known Crohn’s disease or positive findings on small bowel imaging were excluded. Patient demographics and CE findings were collected from patient notes, electronic results or referral information. CE videos were interpreted by one of three gastroenterology consultants experienced in interpreting SBCE video. <h3>Results</h3> 61 patients were referred for SBCE following negative small bowel imaging of which 14 (22.9%) patients had positive findings on SBCE. 9 (64.3%) were female (age range of 17–66 years; mean 42 years). 1 patient (7.1%) had pathology in the proximal SB, 2 (14.3%) in the mid SB, 6 (42.3%) in the distal SB whilst 6 (42.3%) had pathology throughout the SB. Prior to SBCE, 5 patients (35.7%) had negative small bowel MRI, 2 (14.3%) had negative CT abdomen, 5 had (35.7%) negative small bowel enema and 2 (14.3%) had both negative MRI and CT abdomen. <h3>Conclusion</h3> SBCE diagnosed Crohn’s disease in 22.9% of patients that was not detectable on small bowel imaging. In our experience, SBCE is a worthwhile investigation in patients in whom there is a high clinical suspicion of Crohn’s disease with previous negative imaging including small bowel MRI. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Van Assche G, Dignass A, Panes J, Beaugerie L, Karagiannis J, Allez M, Stange E. The second European evidence-based consensus on the diagnosis and management of Crohn’s disease: definitions and diagnosis. J Crohns Colitis 2010;4(1):7–27 Triester SL, Leighton JA, Leontiadis GI, Gurudu SR, Fleischer DE, Hara AK, Sharma VK. A meta-analysis of the yield of capsule endoscopy compared to other diagnostic modalities in patients with non-stricturing small bowel Crohn’s disease. Am J Gastroenterol. 2006;101(5):954–964 Gölder SK, Schreyer AG, Endlicher E, Feuerbach S, Schölmerich J, Kullmann F, Herfarth H. Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease. Int J Colorectal Dis. 2006;21(2):97–104
Clinicopathological features of acute kidney injury associated with immune checkpoint inhibitors
Authors: Frank B. Cortazar, Kristen A. Marrone, Megan L. Troxell, Kenneth M. Ralto, Melanie P. Hoenig, Julie R. Brahmer, Dung T. Le, Evan J. Lipson, Ilya G. Glezerman, Jedd Wolchok, Lynn D. Cornell, Paul Feldman, Michael B. Stokes, Sarah A. Zapata, F. Stephen Hodi, Patrick A. Ott, Michifumi Yamashita, David E. Leaf
Journal: Kidney International (2016)
Eosinophils and Asthma
Authors: A B Kay
Journal: New England Journal of Medicine (1991)

To the Editor: Bousquet et al. (Oct. 11 issue)1 and others2 2345 report that there is a general association between numbers of eosinophils and the severity of asthma. Unfortunately, the controls for their bronchial-biopsy data1 may not have been appropriate, since material obtained post mortem canno
REM latency and the recovery from depression: getting over divorce
Authors: R D Cartwright, H M Kravitz, C I Eastman, E Wood
Journal: American Journal of Psychiatry (1991)

The authors' goal was to address five questions: 1) What is the frequency of early REM sleep in subjects in the process of divorce who meet diagnostic criteria for major depressive disorder? 2) What is the frequency of this sign in subjects in the process of divorce who are not depressed? 3) How often does this sign persist following remission of depressive symptoms? 4) What is the predictive value of early REM sleep among depressed subjects for later adjustment to the process of divorce? and 5) What is the role of a family history of depression or alcoholism in the presence and persistence of early REM sleep?Two hundred fourteen volunteers undergoing marital separation were recruited; 70 of these subjects were selected for a 3-night sleep study. Forty of the 70 subjects met criteria for depression and 30 did not; 61 (87%) returned for repeat studies 1 year later.Fifteen (38%) of the 40 depressed subjects had short REM latency. Seven of these continued to have short REM latency 1 year later, but none of these met the criteria for depression at that time. A higher proportion of these subjects had made a good adjustment to their new life than did depressed subjects whose initial and follow-up REM latencies fell within the normal range.These data suggest that depressed individuals with normal REM latency may need more aggressive treatment intervention.
THE ANEMIA OF PREMATURE INFANTS
Authors: J BALMES, G OLIVIER
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The IDO inhibitor INCB024360 to enhance dendritic cell immunogenicity and anti-tumor immunity in vitro.
Authors: Caroline Jochems, Anna Kwilas, Young-Seung Kim, Martin W. Brechbiel, James W. Hodge, Robert Charles Newton, Jeffrey Schlom, Kwong-Yok Tsang
Journal: Journal of Clinical Oncology (2015)

e14012 Background: INCB024360 is a novel inhibitor of indoleamine-2,3-dioxygenase, which potently suppresses systemic tryptophan catabolism and tumor growth. It is currently being evaluated in several ongoing clinical trials. We investigated the effects of INCB024360 on (a) human dendritic cells (DCs) with respect to maturation and antigen presentation as determined by phenotypic analysis, (b) activation of tumor antigen (MUC1-C and brachyury)–specific cytotoxic T-cells (CTL), and subsequent CTL lysis of tumor cells, and (c) regulatory T-cells (Tregs). Methods: Human DCs were generated from PBMCs of healthy donors and cancer patients, and matured with IFNγ (50 ng/ml) and LPS (1 µg/ml) for 48 hours to induce IDO production. The DCs were then used for flow cytometry, or used for stimulation of CTL or Tregs. Cell proliferation, cytokine production and lysis of tumor cells by peptide-specific CTL derived from cancer patients were evaluated. HPLC was used to determine the levels of tryptophan and kynurenine in supernatants. Results: Treatment with INCB024360 for 48 hours did not change the expression levels of CD80, CD83, PD-1, PD-L1, or B7-DC (PD-L2) on IFNγ/LPS matured human DCs. As expected, treatment with INCB024360 decreased the levels of kynurenine in supernatants. MUC1-C peptide specific CTL stimulated with DCs pulsed with peptide produced significantly more IFNγ after treatment with INCB024360 (2,750 pg/ml at 1µM, and 602 pg/ml at 0.25 µM, compared to < 15.6 pg/ml at 0 µM). They also produced more TNFα, GM-CSF and IL-8, and displayed higher levels of tumor cell lysis (70% vs. 55% at a 30:1 effector: target ratio). Brachyury peptide specific CTL from an additional cancer patient increased the lysis of the human breast cancer cell line MDA-MB231 from 3.5% to 26.9% after 48h treatment with 1 µM INCB024360. Moreover, INCB024360 significantly decreased Treg proliferation induced by IDO production from IFNγ/LPS matured human DCs, although there were no differences in the expression levels of FoxP3, CCR4 or CTLA4 on the Tregs. Conclusions: These results thus demonstrate several effects of INCB024360 on human DCs, CTL and Tregs that could potentially increase the efficacy of immunotherapeutics, including cancer vaccines.