tbuckley/cabot-search huggingface dataset:
Allogeneic Stem Cell Transplantation In Philadelphia Negative Myeloproliferative Or Myelodysplastic/Myeloproliferative Neoplasms: A Retrospective Analysis From The Societe Française De Greffe De Moelle Et De Therapie Cellulaire (SFGM-TC)
Authors: Xavier Cahu, Patrice Chevallier, Aline Clavert, Felipe Suarez, Mauricette Michallet, Nathalie Fegueux, Stephane Vigouroux, Didier Blaise, Gérard Socié, Clara Mariette, Karin Bilger, Ibrahim Yakoub-Agha, Regis Peffault de Latour, Mohamad Mohty
Journal: Blood (2013)
Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis
Authors: Rajesh Shah, Julia L. Cope, Dorottya Nagy-Szakal, Scot Dowd, James Versalovic, Emily B. Hollister, Richard Kellermayer
Journal: Gut Microbes (2016)

Inflammatory bowel diseases (IBD) are chronic intestinal inflammatory disorders characterized by a complex disruption of the physiologic interaction between the host immune system and intestinal microbes precipitated by environmental factors. Numerous observations indicate the altered composition and function of the intestinal microbiome of patients with ulcerative colitis (UC), a subtype of IBD. The accuracy of these results may be limited by confounding factors, such as concurrent medication use. To address these limitations, we examined the colonic mucosal microbiome of pediatric patients with UC prior to initiating treatment. Based on bacterial 16S rRNA gene sequencing, we identified a significant decrease in the phylum Verrucomicrobia in patients with UC. At the genus level, we observed a significant decrease in the short chain fatty acid producer Roseburia. Despite these compositional changes, we did not identify inferred gene content differences between the UC and control groups. To determine if microbial taxa may be associated with clinical outcomes, we retrospectively assessed the clinical course of the UC patients. Despite similar metrics of OTU richness and diversity, multiple OTU differences were observed between patients who responded to therapy and those who did not. Our observations regarding the mucosal microbiome and the associations with differential clinical outcomes support the contributions of gut microbes to disease onset and modulation.
Daratumumab depletes CD38+ immune regulatory cells, promotes T-cell expansion, and skews T-cell repertoire in multiple myeloma
Authors: Jakub Krejcik, Tineke Casneuf, Inger S. Nijhof, Bie Verbist, Jaime Bald, Torben Plesner, Khaja Syed, Kevin Liu, Niels W. C. J. van de Donk, Brendan M. Weiss, Tahamtan Ahmadi, Henk M. Lokhorst, Tuna Mutis, A. Kate Sasser
Journal: Blood (2016)
Congenital Arteriovenous Fistulas of the Extremities
Authors: J P DELANEY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Serum Enzymes. II. Glycolytic Enzymes in Patients with Cancer and Other Diseases&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Laurens P. White, M.D.
Journal: JNCI Journal of the National Cancer Institute (1958)

Abnormal activity of several glycolytic enzymes was found in the serums of many patients with metastatic cancer. Of the enzymes measured, lactic dehydrogenase activity was most often abnormal. Most cancer patients in whom abnormal serum enzyme activities were found were also shown to excrete abnormally large amounts of creatine in the urine. Of conditions commonly associated with creatinuria, such as muscular dystrophy, dermatomyositis, pregnancy, thyrotoxicosis, malnutrition, and amputation, only muscular dystrophy and dermatomyositis were regularly accompanied by abnormal serum enzyme activity. Abnormal serum enzyme activities were frequently found in patients with recent myocardial infarction, hepatitis, nephritis, cerebral vascular accidents, and a variety of miscellaneous conditions not usually associated with creatinuria. The wide variety of conditions that were accompanied by abnormal serum activity of the various glycolytic enzymes only serve to emphasize the ubiquitousness of these enzymes in various body tissues and the lack of diagnostic specificity of abnormal serum activities of aldolase, phosphohexose isomerase, glutamic-oxalacetic transaminase, and lactic dehydrogenase.
Research on the results of psychotherapy: a summary of evidence
Authors: N B Epstein, L A Vlok
Journal: American Journal of Psychiatry (1981)

The authors present a basic overview of recent research on the outcome of psychotherapy, considering different types of therapy and different diagnostic categories separately. In some studies psychotherapy was more efficacious than spontaneous remission or placebo effects, especially in cases of anxiety and in nonpsychotic depression. As an adjunct to drugs and/or ECT, psychotherapy was effective in lowering the relapse rate of schizophrenic outpatients. Psychotherapy appeared to be more effective when focusing on realistic, relevant issues and when teaching social skills. Family therapy may be the most robust mode in terms of consistent positive results with different problems. Although results continue to be mixed, methodological progress is apparent and optimism for continued progress is warranted.
BMA responds to junior doctor committee leak
Authors: Abi Rimmer
Journal: BMJ (2016)

Private discussions should not be mistaken for BMA strategy, the association has said in the light of leaked messages between members of the BMA Junior Doctors Committee (JDC) executive group.

On 26 May, the Health Service Journal (HSJ) published an article that showed leaked conversations between members of the JDC executive group, discussing the ongoing contract dispute.

The messages revealed that JDC chair Johann …
Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses
Authors: M Fidanza, A E Seif, A DeMicco, N Rolf, S Jo, B Yin, Y Li, D M Barrett, J Duque-Afonso, M L Cleary, C H Bassing, S A Grupp, G S D Reid
Journal: Leukemia (2016)
Late detection of a shigellosis outbreak in a school in Madrid
Authors: J Jonsson, M C del Álvarez-Castillo, J C Sanz, R Ramiro, E Ballester, M Fernánez, A Echeíta, J. F. Martinez Navarro
Journal: Eurosurveillance (2005)

Even though shigellosis in Spain is rare, an indigenous outbreak is occasionally detected. We describe an outbreak in a school in Madrid caused by person-to-person transmission of Shigella sonnei. After the detection of Shigella sonnei in a stool sample from a 3 year old girl, an investigation at her school was initiated. Questionnaires were distributed to the parents of 520 pupils attending the school. A case was defined as a school case if it was the first case in a child's household, and as a household case if other members of the household had fallen ill first. We identified 88 cases (60 pupils and 28 of their family members). The attack rate (AR) was 12% in the school and 32% in the families. There was a significant association between higher AR and lower age. The outbreak lasted for two months. The length and the shape of the epidemic curve of the 60 cases in pupils suggests person-to-person transmission. Shigella sonnei isolated from 5 different cases were typed by pulsed field gel electrophoresis (PFGE) and was found to be an identical strain. The prolonged duration of the outbreak was probably due to delayed detection, and stopped as soon as control measures were introduced.
Persistent Hemichorea
Authors: Hiroya Kuwahara
Journal: New England Journal of Medicine (2013)

A 65-year-old man presented with a 10-year history of involuntary movements of his left hand. Neurologic examinations showed hemichorea in his left arm (see video) that disappeared during sleep. Computed tomography of the brain revealed a calcified lesion in the right putamen (Panel A). T2-weighted magnetic resonance imaging of the brain showed mixed signal intensity, with a central core and a peripheral rim of decreased intensity in the right putamen (Panels B and C) that suggested cavernous angioma. The results of magnetic resonance angiography were normal. Oral intake of haloperidol, sodium valproate, and zonisamide did not improve the . . .
Strickland Goodall Memorial
Authors: D. St. Cyres, R. L. Harmsworth, J. Berry, C. Carpenter, J. Cohen, A. W. Sheen, J. W. Eyre, G. Joseph, R. J. Reynolds, D. E. Bedford, B. Mendleson, M. Richards, L. Rogers, T. J. Hoskin
Journal: BMJ (1935)
Paclitaxel for the treatment of lymphoma.
Authors: A Younes
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.6.2289 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9626239 Paclitaxel for the treatment of lymphoma. A YounesxA YounesSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.6.2289 PDF "Paclitaxel for the treatment of lymphoma.." Journal of Clinical Oncology, 16(6), pp. 2289–2290© 1998 by American Society of Clinical Oncology
Effect of Cyclopropenoid Compounds on the Carcinogenic Activity of Diethylnitrosamine and Aflatoxin B in Rats 2 3
Authors: J. E. Nixon, R. O. Sinnhuber, D. J. Lee, M. K. Landers, J. R. Harr
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Effect of Cyclopropenoid Compounds on the Carcinogenic Activity of Diethylnitrosamine and Aflatoxin B in Rats Get access J. E. Nixon, J. E. Nixon Search for other works by this author on: Oxford Academic PubMed Google Scholar R. O. Sinnhuber, R. O. Sinnhuber Search for other works by this author on: Oxford Academic PubMed Google Scholar D. J. Lee, D. J. Lee Search for other works by this author on: Oxford Academic PubMed Google Scholar M. K. Landers, M. K. Landers Search for other works by this author on: Oxford Academic PubMed Google Scholar J. R. Harr J. R. Harr Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 53, Issue 2, August 1974, Pages 453–458, https://doi.org/10.1093/jnci/53.2.453 Published: 01 August 1974 Article history Received: 20 December 1973 Accepted: 18 April 1974 Published: 01 August 1974
Common Errors in Current Surgical Practice: Retrospective Evaluation of Forty Patients
Authors: A A KAMBOURIS, H C SALTZSTEIN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Treatment of Obesity
Authors: Bruce M. Wolfe, Elizaveta Kvach, Robert H. Eckel
Journal: Circulation Research (2016)

This review focuses on the mechanisms underlying, and indications for, bariatric surgery in the reduction of cardiovascular disease (CVD), as well as other expected benefits of this intervention. The fundamental basis for bariatric surgery for the purpose of accomplishing weight loss is the determination that severe obesity is a disease associated with multiple adverse effects on health, which can be reversed or improved by successful weight loss in patients who have been unable to sustain weight loss by nonsurgical means. An explanation of possible indications for weight loss surgery as well as specific bariatric surgical procedures is presented, along with review of the safety literature of such procedures. Procedures that are less invasive or those that involve less gastrointestinal rearrangement accomplish considerably less weight loss but have substantially lower perioperative and longer-term risk. The ultimate benefit of weight reduction relates to the reduction of the comorbidities, quality of life, and all-cause mortality. With weight loss being the underlying justification for bariatric surgery in ameliorating CVD risk, current evidence-based research is discussed concerning body fat distribution, dyslipidemia, hypertension, diabetes mellitus, inflammation, obstructive sleep apnea, and others. The rationale for bariatric surgery reducing CVD events is discussed and juxtaposed with impacts on all-cause mortalities. Given the improvement of established obesity-related CVD risk factors after weight loss, it is reasonable to expect a reduction of CVD events and related mortality after weight loss in populations with obesity. The quality of the current evidence is reviewed, and future research opportunities and summaries are stated.
Abstract IA05: Genome-wide views into the mechanisms of transcription regulation
Authors: John T. Lis, Charles Danko, Fabiana Duarte, Dig Bijay Mahat
Journal: Cancer Research (2016)

Abstract RNA Polymerase II (Pol II) is the molecular machine that transcribes all the protein-encoding mRNAs as well as a spectrum of non-coding regulatory RNAs. The distribution of Pol II reveals not only location and levels of transcription of these transcribed genes, but also, the distinctive patterns of divergent transcription that can be used to identify the active promoters and enhancers that regulate these genes. Moreover, by monitoring changes in the distribution of Pol II across genomes in response either to regulatory signals and to directed perturbations of transcription factors, the distinct steps in transcription that are regulated can be elucidated. With increasing positional and temporal resolution provided by new, genome-wide nuclear run-on and chromatin assays, we are able to gain critical insights into the mechanisms governing how polymerases initiate and elongate through transcription units, and into how these processes are regulated. In this presentation, I will provide a comprehensive genome-wide view of the rapid and dramatic changes in transcription that accompany the stress response, a long used model for studying regulation, and the factors and molecular mechanisms that regulate this reprogramed transcriptional response in both Drosophila and mammals. Citation Format: John T. Lis, Charles Danko, Fabiana Duarte, Dig Bijay Mahat. Genome-wide views into the mechanisms of transcription regulation. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr IA05.
Abstract PR05: Dicer1 deletion: Sufficient for angiosarcoma development and a haploinsufficient tumor suppressor in rhabdomyosarcoma
Authors: Jason A. Hanna, Matthew R. Garcia, Jerold Rehg, Mark E. Hatley
Journal: Cancer Research (2016)

Abstract In this study, the role of Dicer and microRNAs (miRNAs) is investigated in pediatric and adult soft tissue sarcomas with the hypothesis that understanding miRNAs and their biogenesis may provide biological insights into the pathogenesis of these diseases and identify novel therapeutic targets. In several mouse models of cancer, Dicer1 is thought to function as a haploinsufficient tumor suppressor where loss of a single allele promotes tumorigenesis yet loss of both alleles is detrimental to tumor formation. Heterozygous germline mutations in DICER1 in humans is associated with rare malignant and benign neoplasias including embryonal rhabdomyosarcoma (ERMS). With DICER1 syndrome mutations found in ERMS, a pediatric soft tissue sarcoma resembling skeletal muscle precursors that fail to differentiate, we sought to further understand the role of Dicer and miRNAs utilizing a transgenic mouse model of ERMS combined with conditional Dicer1Flox/Flox null mice. The ERMS mouse model results from activation of a constitutively active SmoM2 allele with Cre recombinase expressed from the adipose protein 2 (aP2) promoter resulting in unrestrained hedgehog signaling in the aP2 lineage. Heterozygous Dicer1 loss led to increased penetrance of and a decrease in latency to onset of tumors. In agreement with the haploinsufficient tumor suppressor model, homozygous Dicer1Flox/Flox mice rarely developed tumors in stark contrast to wild type and heterozygous littermates. Furthermore, tumors that did develop in Dicer1Flox/Flox mice escaped Cre recombination and retained a flox allele indicating functional Dicer1 activity. Serendipitously, aP2-Cre; SmoM2; Dicer1Flox/Flox mice that did not develop ERMS all developed multifocal angiosarcomas. This finding prompted the analysis of Dicer loss alone in the aP2 lineage and remarkably Dicer1Flox/Flox mice similarly developed angiosarcoma whereas Dicer1Flox/+ do not, providing evidence for Dicer loss independent of a cooperating oncogene driving tumorigenesis in a mouse model. This study provides evidence for the role of Dicer and miRNAs in rhabdomyosarcoma and angiosarcomas. Further understanding the molecular mechanisms and genetic drivers of soft tissue sarcomas is critical for the development of novel targeted therapeutics. This is true especially for soft tissue sarcomas where treatment strategies and survival outcomes have not changed in decades despite numerous clinical trials. This abstract is also presented as Poster B06. Citation Format: Jason A. Hanna, Matthew R. Garcia, Jerold Rehg, Mark E. Hatley. Dicer1 deletion: Sufficient for angiosarcoma development and a haploinsufficient tumor suppressor in rhabdomyosarcoma. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr PR05.
Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy
Authors: Weijie Ma, Barbara M. Gilligan, Jianda Yuan, Tianhong Li
Journal: Journal of Hematology & Oncology (2016)

Modulating immune inhibitory pathways has been a major recent breakthrough in cancer treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programed cell-death protein 1 (PD-1) have demonstrated acceptable toxicity, promising clinical responses, durable disease control, and improved survival in some patients with advanced melanoma, non-small cell lung cancer (NSCLC), and other tumor types. About 20 % of advanced NSCLC patients and 30 % of advanced melanoma patients experience tumor responses from checkpoint blockade monotherapy, with better clinical responses seen with the combination of anti-PD-1 and anti-CTLA-4 antibodies. Given the power of these new therapies, it is important to understand the complex and dynamic nature of host immune responses and the regulation of additional molecules in the tumor microenvironment and normal organs in response to the checkpoint blockade therapies. In this era of precision oncology, there remains a largely unmet need to identify the patients who are most likely to benefit from immunotherapy, to optimize the monitoring assays for tumor-specific immune responses, to develop strategies to improve clinical efficacy, and to identify biomarkers so that immune-related adverse events can be avoided. At this time, PD-L1 immunohistochemistry (IHC) staining using 22C3 antibody is the only FDA-approved companion diagnostic for patients with NSCLC-treated pembrolizumab, but more are expected to come to market. We here summarize the current knowledge, clinical efficacy, potential immune biomarkers, and associated assays for immune checkpoint blockade therapies in advanced solid tumors.
Calcium: pacesetting the periodic psychoses
Authors: J S Carman, R J Wyatt
Journal: American Journal of Psychiatry (1979)

In this double-blind study dihydrotachysterol (DHT) was given orally to eight psychotic patients; in each case marked increases in psychosis and agitation accompanied increases in serum calcium and phosphorus within two weeks after active drug was substituted for placebo. In the three patients whose psychoses exhibited periodic spontaneous exacerbations, the agitated episodes grew more severe. Serum creatine phosphokinase (CPK) increased in all but one patient. By contrast, when three periodically psychotic patients received synthetic salmon calcitonin (SCT), the severity and frequency of agitated episodes decreased while CSF calcium increased in all three. These data support the hypothesis that the observed abrupt increases in serum calcium and phosphorus might cause the opposite CSF calcium shifts, the behavioral agitation and the increases in serum CPK frequently noted during acute psychosis.
Abstract 20: Mutation profiling reveals distinct signatures in hypopharyngeal squamous cell carcinoma
Authors: Zhiye Liu, Lai Wei, Dewei Zhao, Ruoyu Wang, Kai Tong, Yuewei Zhang, Bin Yang, Hong Cao, Nina Li, Shanshan Liang, Jiahuan Gu, Zhiqiang Wang, Yan Ding
Journal: Clinical Cancer Research (2016)

Abstract The mutational profiles of hypopharyngeal squamous cell carcinoma (HSCC), an anatomical and clinical subtype of head and neck squamous cell carcinoma (HNSCC) was characterized in this study. Whole exome sequencing of HSCC tumors (n=15) and normal pairs (n=15) reveals distinct somatic gene mutations to HSCC (KDR, ABL-1, ATM, and HNF1A), while some others are common to HNSCC significantly mutated genes (e.g. TP53, HRAS, NOTCH1 and PIK3CA). Copy number analysis shows distinct signatures of HSCC gene amplifications(e.g. CCND1) or deletions(e.g. GSTT1). Furthermore, pathway analysis identified several statistically significant enriched pathways (e.g. VEGFR signaling) for genomic alterations specific to HSCC. We then performed targeted therapies to individual patients corresponding to their mutation profiles, and monitored their responses to the personalized treatment by enumerating the circulating tumor cells. These findings offer new insights into understanding fundamental tumorigenic mechanisms of HSCC and exploring precise therapies. Citation Format: Zhiye Liu, Lai Wei, Dewei Zhao, Ruoyu Wang, Kai Tong, Yuewei Zhang, Bin Yang, Hong Cao, Nina Li, Shanshan Liang, Jiahuan Gu, Zhiqiang Wang, Yan Ding. Mutation profiling reveals distinct signatures in hypopharyngeal squamous cell carcinoma. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Integrating Clinical Genomics and Cancer Therapy; Jun 13-16, 2015; Salt Lake City, UT. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(1_Suppl):Abstract nr 20.