tbuckley/cabot-search huggingface dataset:
Cachexia in Radiotherapy-Treated Patients With Head and Neck Cancer
Authors: Rosario Mazzola, Alba Fiorentino, Filippo Alongi
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Visualization of Lymph Nodal and Hepatic Metastases of Medullary Thyroid Carcinoma on 18F-Fluoride PET/CT
Authors: Rômulo Hermeto Bueno do Vale, José Flávio Gomes Marin, Paulo Schiavom Duarte, Marcelo Tatit Sapienza, Carlos Alberto Buchpiguel
Journal: Clinical Nuclear Medicine (2015)

F-fluoride uptake in soft tissue metastases has been previously described. Herein, we report a case of F-fluoride uptake in lymph nodal and hepatic metastases of medullary thyroid carcinoma. Simultaneous CT showed calcified lesions in these regions.
Treatment of a bile duct leak with ERCP double-balloon enteroscopy in a patient with Roux-en-Y reconstruction
Authors: Gerardo Blanco-Velasco, Juan Blancas-Valencia, Oscar Hernández-Mondragón, Aracely Muñoz-Bautista, María Altamirano-Castañeda, Héctor Chavez-Piña
Journal: Endoscopy (2016)

A 75-year-old man previously presented with gastric outlet obstruction caused by a pyloric peptic stricture, which did not respond to balloon dilation. He required surgical treatment with a Roux-en-Y reconstruction in 2011. Four years later, he presented an episode of cholecystitis, and an open partial cholecystectomy was performed after discovery of gallbladder empyema. Postoperative biliary leakage occurred, with drainage of 350 mL/day through external drains. A magnetic resonance cholangiopancreatography confirmed the presence of a biliary collection and a cystic duct leak ([Fig. 1]).
Case 7-1976
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Frank C. Wheelock, Austin L. Vickery
Journal: New England Journal of Medicine (1976)

Presentation of CaseA 38-year-old woman was admitted to the hospital because of bleeding per rectum.There was a long history of alcohol abuse and chronic liver disease, with slight chronic anemia that was treated with iron and folic acid. Mild, variable hypertension was found nine years before entry. Two years before admission the patient began to have grand-mal seizures, which were attributed to alcohol withdrawal and were treated with diphenylhydantoin sodium and phenobarbital. During the two years before entry she noticed the occasional appearance of bright-red blood on the surface of her stools. Four days before admission she observed . . .
Further evidence that a placebo response to antidepressants can be identified
Authors: F M Quitkin, J W Stewart, P J McGrath, E Nunes, K Ocepek-Welikson, E Tricamo, J G Rabkin, D F Klein
Journal: American Journal of Psychiatry (1993)

The authors' goal was to analyze the acute phase of antidepressant drug treatment to identify placebo responses.Patients rated as improved after 6 weeks of double-blind treatment with imipramine or phenelzine were followed for an additional 6 weeks of double-blind treatment. Initial responses were classified according to the speed of improvement (abrupt or gradual), the persistence or nonpersistence of improvement, and the timing of improvement (early or late onset).It was predicted that patients with nonpersistent, abrupt responses to the drugs were actually experiencing a placebo response and would have the worst prognosis. In fact, this group accounted for a disproportionate number of the relapses. Nonpersistent responders to a drug had a 23.7% relapse rate, but persistent responders had only a 9.0% relapse rate, a significant difference.The authors conclude that a significant proportion of relapses within the first 6 weeks of treatment with an active drug are not related to loss of a true drug effect. Rather, some are related to loss of nonspecific placebo effects, and abrupt nonpersistent responses during drug treatment are most likely the result of placebo effects.
THU0246 Procalcitonin Test in the Differential Diagnosis of Infections and Rheumatic Diseases
Authors: B.S. Belov, G.M. Tarasova, E.N. Aleksandrova, A.A. Novikov
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Estimation of serum procalcitonin (PCT) levels is of great interest in rheumatology for both the diagnosis of co-infections and the differential diagnosis between rheumatic disease activity and the current infectious process. <h3>Objectives</h3> To estimate the value of PCT as a specific marker for generalized and local infection in rheumatic patients. <h3>Methods</h3> A retrospective study of the case histories of 100 inpatients was performed. Serum PCT concentrations were determined by a quantitative electrochemiluminescence assay using a Cobas E 411 analyzer (Roche, Switzerland). <h3>Results</h3> Infectious diseases were diagnosed in 41 of the 100 patients. The infectious process was generalized and local in 11 and 30 cases, respectively. In patients with generalized infection, the level of PCT was more than 2.0 ng/ml in 81.8% of the cases. In cases of local infection and non-infection groups, it was below 0.5 mg/ml in 70% and 84.7% of cases, respectively. In the generalized infection group, the content of PCT was significantly higher than in local infection (p=0.004) and non-infection (p=0.0001) groups (table). It did not depend on rheumatic disease activity. C-reactive protein levels and erythrocyte sedimentation rate correlated with PCT concentrations in different patient groups. ROC analysis showed the optimal sensitivity (82%) and specificity (98%) of PCT as a marker of systemic infection only in rheumatic patients with its concentration of ≥2.3 ng/ml. Thus the positive predictive value was 0,9. This shows high clinical informativeness of the test. <h3>Conclusions</h3> PCT evaluation can be used to facilitate the diagnosis of generalized infections and the differential diagnosis of systemic rheumatic diseases and infectious ones. But PCT results must be interpreted considering available symptom complex and additional examination data. Questions of PCT cut off points determination are worthy of further examination in prospective comparative studies. <h3>Disclosure of Interest</h3> None declared
Recombinant Human IL-12 Promotes NK Cell Migration: Increased CXCL10, Co-Receptors IL-12Rβ2 and CXCR3, and Bright CD56 NK Cells In Healthy Human Subjects
Authors: Simmy Thomas, Chris E. Lawrence, Vernon Mar, Hue Kha, Vladimir Vainstein, Mamata Gokhale, Lena A. Basile
Journal: Blood (2013)
The Risk of Developing Lung Cancer and Its Relationship to Smoking
Authors: S J CUTLER, D B LOVELAND
Journal: JNCI Journal of the National Cancer Institute (1954)

Journal Article The Risk of Developing Lung Cancer and Its Relationship to Smoking Get access Sidney J. Cutler, Sidney J. Cutler Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Donald B. Loveland Donald B. Loveland Biometry Section, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 1, August 1954, Pages 201–211, https://doi.org/10.1093/jnci/15.1.201 Published: 01 August 1954 Article history Received: 02 April 1954 Published: 01 August 1954
Early rheumatoid arthritis treated with tocilizumab, methotrexate, or their combination (U-Act-Early): a multicentre, randomised, double-blind, double-dummy, strategy trial
Authors: Johannes W J Bijlsma, Paco M J Welsing, Thasia G Woodworth, Leonie M Middelink, Attila Pethö-Schramm, Corrado Bernasconi, Michelle E A Borm, Cornelis H Wortel, Evert Jan ter Borg, Z Nazira Jahangier, Willemijn H van der Laan, George A W Bruyn, Paul Baudoin, Siska Wijngaarden, Petra A J M Vos, Reinhard Bos, Mirian J F Starmans, Eduard N Griep, Joanna R M Griep-Wentink, Cornelia F Allaart, Anton H M Heurkens, Xavier M Teitsma, Janneke Tekstra, Anne Carien A Marijnissen, Floris P J Lafeber, Johannes W G Jacobs
Journal: The Lancet (2016)
Surgical Treatment of Chronic Suppuration of the Middle Ear and Mastoid.
Journal: JAMA (1906)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Establishment of Clones of Epithelial Cells from Human Skin&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Vernon P. Perry, Katherine K. Sanford, Virginia J. Evans, George W. Hyatt, Wilton R. Earle
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Establishment of Clones of Epithelial Cells from Human Skin Get access Vernon P. Perry, Vernon P. Perry Naval Medical School and National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Katherine K. Sanford, Katherine K. Sanford Naval Medical School and National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Virginia J. Evans, Virginia J. Evans Naval Medical School and National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar George W. Hyatt, George W. Hyatt Naval Medical School and National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle Wilton R. Earle Naval Medical School and National Cancer Institute, Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 18, Issue 5, May 1957, Pages 709–717, https://doi.org/10.1093/jnci/18.5.709 Published: 01 May 1957 Article history Received: 02 January 1957 Published: 01 May 1957
High Doses of Antimetabolites Followed By High-Dose Sequential Chemoimmunotherapy and Autologous Stem Cell Transplant in Patients with Systemic B-Cell Lymphoma and Secondary Central Nervous System Involvement: Final Results of a Multicenter Phase II Trial
Authors: Andrés J.M. Ferreri, Giovanni Donadoni, Maria Giuseppina Cabras, Caterina Patti, Michael Mian, Renato Zambello, Corrado Tarella, Massimo Di Nicola, Alfonso D'Arco, Gianluca Doa, Marta Bruno-Ventre, Marco Foppoli, Alessandro Fanni, Antonino Mulè, Fabio Ciceri, Federico Caligaris-Cappio
Journal: Blood (2014)
The usefulness of DSM-III axis IV and axis V assessments
Authors: G Schrader, M Gordon, R Harcourt
Journal: American Journal of Psychiatry (1986)

DSM-III multiaxial diagnoses were given to 257 patients. Analysis of axis I diagnoses and axis IV and axis V assessments generally revealed the expected associations between particular psychiatric disorders and levels of psychosocial stress and social and occupational functioning. However, a major difficulty affecting the usefulness of axis IV and axis V data when they are routinely gathered according to the current DSM-III instructions is the stipulation that the clinician judge the etiological significance of a stressor before it is coded.
Abstract 157: Toll like Receptor 4 Activation Promotes Cardiac Arrhythmias By Decreasing The Transient Outward Potassium Current (ito) Through An Irf3 dependent And Myd88 independent Pathway
Authors: Emiliano Medei, Gustavo Monnerat-Cahli, Hiart Alonso, Monica Gallego, Micaela Lopez Alarcon, Rosana A Bassani, Oscar Casis
Journal: Circulation Research (2014)

Cardiac arrhythmias are one of the main causes of death worldwide. Several studies have shown that inflammation plays a key role in different cardiac diseases and Toll like receptors (TLR’s) play an important role in cardiac complications. In the present study, we investigated whether the activation of TLR4 induces cardiac electrical remodeling and arrhythmias. Also the signaling pathway involved in these phenomena was studied. Action potentials, the presence of cardiac arrhythmias and transient outward K + current (I to ) were recorded in Wistar rat’s hearts after 24 h exposure to the TLR4 agonist ultrapure Lipopolysaccharide (LPS - 1μg/ml). TLR4 stimulation in vitro promotes a cardiac electrical remodeling that leads to cardiac action potential prolongation which evokes arrhythmic events such as delayed after depolarization (DAD's) and triggered activity. The perfusion of LPS (1μg/ml) during 30 minutes did not modify I to . Conversely, after 24 h of LPS incubation I to was reduced, with no changes in the biophysical properties of the current. Major changes in Ca 2+ cycling were not observed in ventricular myocytes after 24 h exposure to LPS; however, extrasystolic activity was present in a considerable number of cells (25%). Neither the blockade of Interleulink-1 receptor-associated kinase 4 nor nuclear factor kappa B (NF-kB) prevented the LPS effect on I to . However, interferon regulatory factor 3 (IRF3) inhibition prevented the effect of TLR4 activation on I to . Activation of TLR4 induced extrasystolic activity, longer AP duration and evoked DAD's and triggered activity because of a reduction in I to . The mechanism involved is MyD88-independent and IRF3-dependent.
Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy
Authors: Wen-Yu Pan, Kun-Ju Lin, Chieh-Cheng Huang, Wei-Lun Chiang, Yu-Jung Lin, Wei-Chih Lin, Er-Yuan Chuang, Yen Chang, Hsing-Wen Sung
Journal: Biomaterials (2016)
Plasma Trimethylamine N -Oxide, a Gut Microbe–Generated Phosphatidylcholine Metabolite, Is Associated With Atherosclerotic Burden
Authors: Vichai Senthong, Xinmin S. Li, Timothy Hudec, John Coughlin, Yuping Wu, Bruce Levison, Zeneng Wang, Stanley L. Hazen, W.H. Wilson Tang
Journal: Journal of the American College of Cardiology (2016)
Teaching the Present State Examination in America
Authors: R E Luria, R Berry
Journal: American Journal of Psychiatry (1980)

The Present State Examination (PSE) has gained increasing acceptance in psychiatric research. As with any clinical method, its usefulness rests not only on its reliability and pertinence but also on how successfully it can be taught. Its teachability is particularly important for American-trained clinicans, given the wide differences between Anglo-European and American clinical practices and the fact that the PSE developed from Anglo-European clinical concepts and techniques. The authors reports that by means of preliminary phenomenological training and formal PSE demonstrations and supervised interviews, the PSE can be readily learned by diverse American-trained clinicians with interrater reliability comparable to that of British and European clinicians.
Are 5-hydroxytryptamine-3 receptor antagonists efficient antiemetics for chemotherapy-induced delayed emesis and do they remain effective over subsequent cycles?
Authors: A Adenis, J Bonneterre
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.10.2235 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7931495 Are 5-hydroxytryptamine-3 receptor antagonists efficient antiemetics for chemotherapy-induced delayed emesis and do they remain effective over subsequent cycles? A AdenisxA AdenisSearch for articles by this author , J BonneterrexJ BonneterreSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.10.2235 PDF "Are 5-hydroxytryptamine-3 receptor antagonists efficient antiemetics for chemotherapy-induced delayed emesis and do they remain effective over subsequent cycles?." Journal of Clinical Oncology, 12(10), pp. 2235–2236© 1994 by American Society of Clinical Oncology
The role of external heat load in triggering the neuroleptic malignant syndrome
Authors: A Shalev, H Hermesh, H Munitz
Journal: American Journal of Psychiatry (1988)

During a heat wave three patients developed neuroleptic malignant syndrome. The role of heat load in triggering this syndrome and possible mechanisms behind such a role are discussed. Data concerning the season of occurrence of neuroleptic malignant syndrome are reported.
SP0082 Glycosylation of Anti-Nuclear Autoantibodies Determines Their Inflammatory Potential
Authors: M. Herrmann
Journal: Annals of the Rheumatic Diseases (2015)

The Fc portion of IgG harbours a single glycosylation site. Glycan sialylation is critical for structure and for certain effector functions of IgG. Anti-histone-IgG of patients with systemic lupus erythemathosus is reportedly responsible for the recruitment of polymorphonuclear cells (PMN) to the clearance of apoptotic cells. Autoantibodies decorating Secondary NEcrotic Cells (SNEC) induce pro-inflammatory responses after activation of blood-borne phagocytes. Analyzing the sialylation status of affinity purified anti-histone-IgG in patients with SLE we demonstrated anti-histone-IgG preferentially contained in the desialylated fraction. In functional ex vivo phagocytosis studies, desialylated anti-SNEC-IgG preferentially directed SNEC into PMN but did not change their cytokine secretion profiles. In contrast, sialylated IgG reduced the phagocytosis by monocytes of SNEC. Moreover, the sialylated anti-SNEC-IgG was not simply anti-inflammatory but switched the cytokine secretion profiles from IL6/IL8 to TNFα/IL1β. Here we described how different sialylation statuses of IgG autoantibodies contribute to the complex inflammatory network that regulates chronic inflammation. <h3>Disclosure of Interest</h3> None declared
Evaluation of a New Analeptic
Authors: R B COUCH, T R CATE, R M CHANOCK
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
SP0250 Implementing Non-Pharmacological Guidelines in Clinical Practice
Authors: P. van der Wees
Journal: Annals of the Rheumatic Diseases (2015)

Clinical practice guidelines are "statements that include recommendations intended to optimize patient care, that are informed by a systematic review of evidence and an assessment of the benefits and harms of alternative care options". In health care services, clinical guidelines are considered important instruments to improve and manage the care process. Important goals in developing and implementing guidelines are higher quality and improved cost-effectiveness of interventions, ideally resulting in improved health outcomes. The growing body of knowledge in the field of clinical guidelines has provided opportunities for international collaboration. In 2002, the Guidelines International Network (G-I-N) was founded to provide a network and partnerships for guideline organizations, implementers, researchers and other stakeholders in health care. G-I-N seeks to improve the quality of health care by promoting the systematic development of guidelines and their application to practice. Despite a multitude of implementation strategies, research has demonstrated that guidelines are not readily implemented in every day clinical practice. The main bottlenecks for practitioners are attributable to knowledge, attitudes and factors concerning social, organizational and societal support. Because education is assumed to be the first step to behavioral change in clinical practice, a variety of educational interventions have been designed addressing knowledge, skills, and attitudes. Peer Assessment is an implementation strategy that aims at developing mutually accepted performance standards and realistic perceptions of actual performance. We will present the effectiveness of peer assessment strategies to enhance the implementation of clinical practice guidelines based on the results of two cluster-randomized clinical trials. <h3>Disclosure of Interest</h3> None declared
Facts and Fallacies Regarding the Blood Pressure of Different Regional and Racial Groups
Authors: ROBERT P. BAYS, NEVIN S. SCRIMSHAW
Journal: Circulation (1953)

The blood pressure cuff reveals higher values in complex societies than in simpler social environments. Evaluation of the importance of this fact necessitates a more exact use of such terms as "high blood pressure" or "hypertensive disease' as applied to an individual, and "mean blood pressure" or "incidence of hypertension" as applied to groups. The inadequacies of the cuff method of blood pressure determination are particularly evident in group studies. From the available facts, a few cautious conclusions may be drawn.