tbuckley/cabot-search huggingface dataset:
SAT0606 Impact of Musculoskeletal Ultrasound in Treatment Decision in Routine Daily Care of Rheumatoid Arthritis (Impulsar Study): Table 1
Authors: E. Toniolo, C. Díaz-Torné, C. Moragues, C. Geli, M. Millán, I. Castellví, P. Moya, A. Laíz, J.M. Llobet
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Remission or low disease activity is the therapeutic target in the ACR-EULAR recommendation for the management of rheumatoid arthritis (RA). In multiple studies, musculoskeletal ultrasound (US) has shown to be more reliable and sensitive than physical examination in both the diagnosis and the assessment of RA activity. However, the real impact of this technique on routine daily care of RA and treatment decisions has not been studied. <h3>Objectives</h3> To assess the proportion of therapeutic decisions that are modified by the results of the US examination in patients with RA. To determine which group of patients would get more benefit from a musculoskeletal US to optimize treatment. <h3>Methods</h3> Seventy eight consecutive patients diagnosed with RA by ACR 1987 criteria and visited between July and November 2014, were included. All patients were initially visited by their usual rheumatologist and a therapeutic decision was made according to physical examination and clinical and laboratory findings. Subsequently, a musculoskeletal US was performed by an expert sonographer of our center and the usual rheumatologist was asked to reassess his therapeutic decision in light of the US findings. We classified the change in the therapeutic attitude as: negative (maintenance of therapeutic attitude) and positive (increase or reduction in treatment, compared to the initial decision). Demographic, clinical and laboratory data were collected from the clinical history and activity scores were calculated. <h3>Results</h3> Clinical, demographic, laboratory, treatment and activity score data are shown in table below. In 29 patients [37.2% (95% CI 26.5 to 48.9)] the findings in the US examination conditioned a change in the therapeutic decision of the usual rheumatologist. In 18 patients (62.07%) the change was towards an intensification of treatment, while in 11 patients (37.93%) a decrease was possible. Change of treatment was more frequent in patients with intermediate disease activity (mild and moderate activity) than in those with extreme activities (remission and high activity), 41.4% vs 25%, although this difference was not statistically significant. A higher frequency of change was found in men (53.8% vs 33.8%) and erosive RA forms (43.6% vs 21.7%), but the results did not reach statistical significance. <h3>Conclusions</h3> Musculoskeletal ultrasound, when added to routine rheumatologic investigation, is an important tool for treatment decisions in the routine daily care of rheumatoid arthritis. Patients with intermediate activities of the disease might get more benefit from the use of an US examination. <h3>Disclosure of Interest</h3> None declared
Ongoing outbreak of invasive listeriosis due to serotype 1/2a Listeria monocytogenes, Ancona province, Italy, January 2015 to February 2016
Authors: Emanuela Marini, Gloria Magi, Chiara Vincenzi, Esther Manso, Bruna Facinelli
Journal: Eurosurveillance (2016)

In the first seven weeks of 2016, five serotype 1/2a Listeria monocytogenes isolates were collected from patients with invasive listeriosis in Ancona province in Italy. These strains and six 1/2a isolates identified in 2015 in the same area were typed by ERIC-PCR and PFGE. A clonal relationship, documented between the two sets of isolates, suggested a listeriosis outbreak in Ancona that started most probably in 2015. Investigation into the source of infection is still ongoing.
OP0081 Identification of a Sjögren's Syndrome-Associated Variant that Influences OAS1 Isoform Switching and Protein Expression
Authors: C. Lessard, H. Li, J.A. Ice, I. Adrianto, C.G. Montgomery, I. Alevizos, T. Witte, M. Rischmueller, M. Wahren-Herlenius, R. Omdal, R. Jonsson, N.L. Rhodus, W.-F. Ng, G. Nordmark, K.L. Sivils
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Sjögren9s syndrome (SS) is a common, autoimmune exocrinopathy characterized by symptoms of dry eyes and mouth present in 0.7% of the European American population. Gene expression profiling (GEP) has previously demonstrated overexpression of transcripts induced by interferons (IFN) in SS patients. <h3>Objectives</h3> In this study, we sought to identify and characterize underlying genetic contributions to dysregulation of IFN pathways in SS. <h3>Methods</h3> IFN signature genes of interest were selected from GEP studies performed in 115 anti-Ro positive SS cases and 73 controls using microarray data and evaluated for <i>cis</i>-expression quantitative trait loci (eQTL) in 178 subjects by integration with genome-wide association study (GWAS) data. Gene splicing patterns were evaluated using RNA-sequencing (RNA-seq) performed in 57 SS cases and 27 controls on the Illumina platform. <h3>Results</h3> GEP showed that <i>OAS1</i>, an IFN-inducible gene involved in inhibition of virus replication, was significantly overexpressed in SS patients. Multiple <i>cis</i>-eQTL were identified in <i>OAS1</i> with the most significant peaking at rs10774671, strengthening prior evidence of this variant for disease association ((<i>p</i>=8.47×10<sup>-5</sup>) obtained in our large GWAS dataset consisting of 765 cases and 3825 controls. We further replicated this genetic association in an independent set of 514 cases and 3466 controls followed by meta-analysis (<i>p</i>=2.59×10<sup>-9</sup>; OR=0.75). The risk allele "A" of rs10774671 is a splice site consensus variant located at the junction between intron-5 and exon-6 of <i>OAS1</i>, and thus may switch the primary isoform, p46, to various alternatives. Transcripts measured by RNA-seq were reconstructed and the abundance of isoforms was compared across samples according to the genotype of rs10774671. The risk allele "A", which demolishes the splicing consensus sequence, was correlated with higher expression of p42, p48, and p44 isoforms, but a lower expression of the normally spiced <i>OAS1</i> isoform, p46. Functional characterization of different <i>OAS1</i> isoforms indicated that the alternatively spliced isoforms resulted in impaired protein expression and lack of response to type I IFNs. <h3>Conclusions</h3> We identified <i>OAS1</i> as a novel candidate SS locus. The risk allele "A" has been reported to result in decreased Oas1 enzyme activity. These results suggest a mechanism in which alternatively spliced <i>OAS1</i> transcripts lead to reduced viral clearance resulting in perpetuation of type I IFN signaling in SS. <h3>Disclosure of Interest</h3> None declared
European surveillance of travel associated legionnaires' disease 1996
Authors: C. R. Lane, C Joseph, C L R Bartlett
Journal: Eurosurveillance (1998)

The European Surveillance Scheme for Travel Associated Legionnaires&#39; Disease was established in 1987 to identify clusters and outbreaks of cases of the disease. Twenty-nine collaborating centres in 25 countries contribute case reports in a standard format
Hypnosis And Suggestion.
Authors: E J Neiburger
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Limited Fixation of Antibody by Viable Cells
Authors: Raymond Hiramoto, Milton N. Goldstein, David Pressman
Journal: JNCI Journal of the National Cancer Institute (1960)

The indirect fluorescent antibody procedure was used to study the reaction of antibody, active against human connective tissue, with living and dead HeLa cells. These antibodies were fixed only at the cell surface of viable HeLa cells and were able to react with intracellular cytoplasmic components only in killed cells. Antiserums to human fibrinogen and human γ-globulin did not give this type of fixation. Components taken up by the cell from the culture medium were demonstrable in the cytoplasm of killed cells.
FRI0291 Decrease in Anti-Osteoporotic Drugs Prescriptions: Is there an Immediate Consequence on Hip Fracture Incidence?
Authors: K. Briot, M. Maravic, C. Roux
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The incidence of hip fractures decreased in France in both genders, especially in the elderly, from 2002 to 2008, in parallel with availability of bone densitometry and effective anti-osteoporotic treatments. However prescriptions of those treatments are decreasing, since 2008, and recent studies show declining of osteoporosis management after fragility fractures. <h3>Objectives</h3> The aim of this study was to assess the incidence of hip fractures in men and women aged 60 years and over, from 2002 to 2013 in France, and to assess the potential effect of these treatment changes. <h3>Methods</h3> Data were drawn from the French Hospital National Database which includes all hospitalizations. Hospital data for hip fractures between 2002 and 2013 were numbered and the incidence rates per 1,000,000 adjusted on age (60-74; 74-84, and ≥85 years), and gender was calculated using the data of the French population. <h3>Results</h3> We did not observe any change in hip fracture incidence before and after 2008; The number of hip fractures increased in women (+5%; from 49,287 in 2002 to 50,215) and in men (+22%, from 12,716 to 15,482). Between 2002 and 2013, the French population increased by 21 and 29% in women and men. Thus, incidence of hip fractures over 60 years decreased by -14% in women (6,929 and 5,987 per million in 2002 and 2013, respectively) and a slight decrease of -1%was observed in men (2,344 and 2,316). An age-specific incidence decrease was also confirmed, with a decrease of -29% and -24% (p&lt;0.00001) in elderly (≥85 years) women and men respectively. <h3>Conclusions</h3> Over the last 12 years, the incidence of hip fractures decreased in France in women and men aged over 60 years. This decrease is particularly important in the elderly in both genders. This is observed although there is a decrease in prescription of antiosteoporotic treatments. Further studies are needed to assess potential changes in hip fractures risk factors during the last decade. <h3>Disclosure of Interest</h3> None declared
Interleukin-2 for metastatic melanoma: treating polyuria with insulin?
Authors: I C Quirt, I F Tannock
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.7.1125 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2193116 Interleukin-2 for metastatic melanoma: treating polyuria with insulin? I C QuirtxI C QuirtSearch for articles by this author , I F TannockxI F TannockSearch for articles by this author https://doi.org/10.1200/JCO.1990.8.7.1125 First Page PDF © 1990 by American Society of Clinical Oncology
Clinical characteristics of 15 patients with tardive dystonia
Authors: P Sachdev
Journal: American Journal of Psychiatry (1993)

Clinical characteristics of 15 consecutively referred patients with tardive dystonia are reported. The onset of tardive dystonia occurred in all age groups and in both sexes, with some preponderance in men. There was considerable overlap with tardive dyskinesia and tardive akathisia. Six subjects reported past acute dystonia, and four had histories of essential tremor, suggesting a vulnerability to the development of dystonia.
Significance and Utilization of Animal Individuality in Disease Research&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;2&lt;/xref&gt;
Authors: John W. Gowen
Journal: JNCI Journal of the National Cancer Institute (1954)

Significance and Utilization of Animal Individuality in Disease Research John W. Gowen John W. Gowen Iowa State College, Ames, Iowa Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 3, December 1954, Pages 553–572, https://doi.org/10.1093/jnci/15.3.553 Published: 01 December 1954
Effect of Penicillin on the Development of Mammary Tumors in Mice Containing the Milk Agent
Authors: B. E. Bennison
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article Effect of Penicillin on the Development of Mammary Tumors in Mice Containing the Milk Agent Get access B. E. Bennison B. E. Bennison National Cancer Institute, National Institutes of Health, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 1, August 1949, Pages 175–178, https://doi.org/10.1093/jnci/10.1.175 Published: 01 August 1949 Article history Received: 13 May 1949 Published: 01 August 1949
Effects of <i>Helicobacter pylori</i>infection on gastric acid secretion and serum gastrin levels in Mongolian gerbils
Authors: M Takashima, T Furuta, H Hanai, H Sugimura, E Kaneko
Journal: Gut (2001)

BACKGROUND AND AIMS Body gastritis caused by Helicobacter pylori infection appears to inhibit gastric acid secretion. The aim of this study was to determine the effects of H pylori infection on gastric acid secretion and clarify its mechanisms with reference to interleukin 1β (IL-1β). METHODS (1) Mongolian gerbils were inoculated orally with H pylori . Before, six, and 12 weeks after inoculation, serum gastrin levels, gastric acid output, and IL-1β mRNA levels in the gastric mucosa were determined. Pathological changes were also determined according to the updated Sydney system. (2) Effects of recombinant human IL-1 receptor antagonist (rhIL-1ra) on gastric acid output and serum gastrin levels were also determined. RESULTS (1) Scores for activity and inflammation of gastritis and serum gastrin levels were significantly increased, and gastric acid output was significantly decreased six and 12 weeks after inoculation with H pylori. IL-1β mRNA levels in the gastric mucosa were also elevated six and 12 weeks after inoculation with H pylori . (2) Acid output and serum gastrin levels in the infected groups returned to control levels after rhIL-1ra injection. CONCLUSIONS Gastric acid secretion is decreased and serum gastrin levels are increased in Mongolian gerbils infected with H pylori . This change in gastric acid secretion appears to be mediated by IL-1β induced by H pylori infection.
PWE-058 Co-designing inflammatory bowel disease (ibd) services in scotland: the patients perspective
Authors: M Schoultz, L Macaden, A Watson
Journal: Gut (2015)

<h3>Introduction</h3> The Scottish Government–s ambition is to ensure that health services are co-designed with the communities they serve. IBD lifelong management has historically been dependent on the available health services. Crohn's and Colitis UK and the Scottish Government have recognised the need to review and update the current IBD care model to a model that reflects the range of daily needs for IBD patients. An online survey was conducted where IBD patients were asked to express their views on what is good about the NHS care they receive, what should improve and anything else they would like to add about living with IBD. This survey is the first step of co-designing and developing a national strategy for IBD service improvement in Scotland. <h3>Aim</h3> To explore IBD patients9 experiences of current services and make recommendation for future service development. <h3>Method</h3> This study was part of a wider on line survey. The online survey was opened between March and May 2014. Participants were IBD patients across Scotland. 777 took part in the survey and 279 participants responded to the open ended questions about their experiences with IBD services. Thematic analysis of all data was conducted independently by two researchers and then grouped under the key themes. <h3>Results</h3> Three key themes emerged from the analysis: 1. Quality of life: IBD patients highlighted the huge impact the disease has on quality of life and the desperate and urgent need for better addressing this in a holistic way. 2. IBD clinicians: IBD patients recognise the need for more IBD nurses and gastroenterologists along with better access to them. Those with a named IBD nurse reported to be more satisfied with their care. 3. Clear IBD care pathway: IBD patients identified that better coordination of care and communication between all departments involved in IBD care delivery is needed along with making the IBD care pathway more explicit to IBD patients. <h3>Conclusion</h3> IBD patients recognise that while living with IBD, their needs are wider than medical and biological; therefore a more holistic approach to their care is needed. While IBD patents with named IBD nurse reported higher satisfaction with their care, they recognise the need for integrating psychological, counselling and dietician services in the IBD care, together with practical advice on how to live with IBD as soon as diagnosed. <h3>Disclosure of interest</h3> None Declared.
Vitiligo‐like depigmentations as the first sign of melanoma: a retrospective case series from a tertiary vitiligo centre
Authors: H.E. Teulings, J.E. Lommerts, A. Wolkerstorfer, L. Nieuweboer‐Krobotova, R.M. Luiten, M.W. Bekkenk, J.P.W. Veen
Journal: British Journal of Dermatology (2016)

patients with melanoma may develop vitiligo-like skin depigmentation referred to as melanoma-associated leukoderma (MAL), melanoma-associated hypopigmentation (MAH), melanoma-associated depigmentation (MAD) or melanoma-associated vitiligo (MAV) 1-3. Many dermatologists are not aware of the diagnosis MAL and may easily diagnose and treat these patients as having non-segmental vitiligo, thereby overlooking the underlying (metastatic) melanoma. At present, the prevalence of MAL and its clinical characteristics are not well established.

This article is protected by copyright. All rights reserved.
Metabolic Effects of Exercise and Multiple-Dose Insulin Regimens in Hyperlabile Diabetes Mellitus
Authors: G D MOLNAR, C F GASTINEAU, J W ROSEVEAR, F H HELMHOLZ, W F McGUCKIN, W L CHENOWETH
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0528 Diagnostic Accuracy of MRI for Evaluating Early Sacroiliac Abnormalities in Juvenile Spondyloarthritis
Authors: M. Bou Antoun, L. Rossi-Semerano, S. Guillaume-Czitrom, I. Kone Paut, C. Adamsbaum
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile spondyloarthritis (jSpA) encompasses a group of disorders characterized by similar clinical manifestations, namely peripheral arthritis and enthesitis, and genetic predisposition (HLAB27). Using the ILAR classification, jSpA includes enthesitis-related arthritis (ERA), juvenile psoriatic arthritis (jPsA) and undifferentiated arthritis. Only clinical signs, familial history and HLAB27 positivity but no imaging features are used in the ILAR classification. Limited data are available concerning the diagnostic accuracy of MRI to detect early sacroiliac joints changes in jSpA. <h3>Objectives</h3> To describe early sacroiliac joints abnormalities with MRI in jSpA. <h3>Methods</h3> This is a retrospective study conducted in a French reference centre for paediatric rheumatic diseases. The study involved patients who had a diagnosis of jSpA by a paediatric rheumatology expert since January 2006 to January 2015. Collected data included: age, gender, disease duration, clinical symptoms and signs (peripheral or axial involvement, extra-articular signs), biological inflammatory markers, HLAB27, plain radiographs and/or MRI made in the first three months after diagnosis. All radiographs and MRIs were analysed by two independent pediatric radiologists (one junior, one senior). <h3>Results</h3> 85 patients (44 males, 41 girls), with a mean age of 11years (range 5-16) were included. Eighty-two out of 85 patients (96,5%) had at least one X ray of a symptomatic joint (35 pelvic bones, 20 knees, 22ankles and 5 spinal joints). Seventy-eight plain radiographs were normal. We found non-specific abnormalities in 4 cases: indirect signs of effusion in 3 knees, and a L5-S1 spondylolysis. Among 51 patients who underwent a MRI of symptomatic joints in the first three months after diagnosis, 37 MRIs were fully available. Of 20 MRIs of hip and sacroiliac joints, we found a normal pattern in 10 cases (50%), mild bilateral (5) or unilateral (3) sacroiliitis (40%) and 2 hip synovitis. We didn9t find any abnormalities in 2 spinal MRIs (1 cervical and 1 lumbar). We found pathological MRI features in peripheral joints: 7 out of 8 knees (3 synovitis and/or effusions, 1 tibial tuberosity enthesitis), and in 5 out 7 ankles (2 enthesitis of Achilles tendon, 1 tenosynovitis of medial ankle tendons, 1 bone marrow oedema (calcaneus), 1 synovitis). <h3>Conclusions</h3> This study confirms that radiographs are not sensitive to detect sacroiliitis in the early stage of jSpA. Moreover, while the accuracy of MRI for the assessment of peripheral arthritis in children with JIA has been widely demonstrated, there is a lack of evidence about the diagnostic accuracy of MRI for evaluating early sacroiliac abnormalities in jSpA. <h3>Disclosure of Interest</h3> None declared
Postfemoral venipuncture hematoma: a potential false-positive gastrointestinal bleeding scan.
Authors: DINESH BHAMBHVANI, DARLENE FINK-BENNETT
Journal: Clinical Nuclear Medicine (2001)

From the William Beaumont Hospital, Department of Nuclear Medicine, 3601 W. 13 Mile Road, Royal Oak, Michigan Received for publication May 31, 2000. Accepted July 12, 2000. Reprint requests: Darlene Fink-Bennett MD, Department of Nuclear Medicine, William Beaumont Hospital, 3601 W. 13 Mile Road, Royal Oak, Michigan 48073. E-mail: [email protected]