tbuckley/cabot-search huggingface dataset:
Abstract 5431: Histone deacetylase inhibitor (HDAC) panobinostat (LBH589) enhances the antiproliferative effect of a topoisomerase II (topo II) inhibitor in doxorubicin-resistant HL-60 cells, despite high MDR expression
Authors: Anna K. Brady, Anjali S. Advani, Dale Grabowski, Ram Ganapathi, Mahrukh K. Ganapathi
Journal: Cancer Research (2010)

Abstract Acute myeloid leukemia (AML) is difficult to treat, particularly in the relapsed or refractory setting due to drug resistance. Topo II inhibitors are effectively used to treat AML, and histone deacetylase (HDAC) inhibitors have been used pre-clinically and clinically with some success. We previously reported that vorinostat (SAHA) was effective in combination with topo II inhibitors in AML cells (Proc. AACR, 2009, Abstract 4567). In the present study we evaluate LBH589, a novel class I/II HDAC inhibitor. Since resistance to HDAC inhibitors has not been well described, we hypothesized that LBH589 would be effective in combination with a topo II inhibitor in a doxorubicin-resistant AML cell line that expresses MDR and resistant by MDR-independent mechanism. A sensitive HL60 parent line (S) and the doxorubicin-resistant sub-line (R) were used. Early studies revealed that vorinostat (SAHA) had comparable anti-proliferative effects in S &amp; R cells but the R cells were relatively more resistant to LBH589. This resistance was likely MDR-mediated. We then tested whether sub-lethal doses of SAHA or LBH589, used in combination with sub-lethal doses of etoposide (VP-16), would be effective. S and R cells were treated with VP-16 for 1 h, washed, and re-incubated with SAHA or LBH, or drug-free media, for a total of 144 hours. Cell viability and apoptosis were measured at 72 h and 144 h following treatment. At 72 h and at 144 h, the combination of VP-16 and LBH was significantly more effective (p&amp;lt;0.01) in reducing proliferation in HL60/S and HL60/R cells, compared to either agent alone. At both 72 h and 144 h the combination of VP-16 and LBH also led to significantly (p&amp;lt;0.05) greater apoptosis in both S &amp; R cells. Western blotting for phospho-histone H2AX, a marker of DNA damage, showed increased DNA damage in the R cells treated with VP-16 and LBH589 compared to either drug alone. Overall, the effects of LBH589 in combination with VP-16 were significantly (p&amp;lt;0.05) more effective than SAHA in the S &amp; R cells. In summary, our results demonstrate that MDR may mediate resistance to LBH589. Further, in spite of MDR expression, LBH589 is a useful adjunct to VP-16 treatment and enhances the anti-proliferative effect of the topo II inhibitor via increased apoptosis, even in the doxorubicin-resistant cells. Thus, post-treatment with LBH589 in combination with a topo II inhibitor may be useful treatment strategy in relapsed / refractory AML. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5431.
AB1041 Bone mineral density in tunisian patients with cirrhosis
Authors: R. Ennaifer, K. Ben Abdelghani, L. Souabni, M. Cheikh, R. Hefaiedh, R. Hayfa, L. Zakraoui, N. Bel Hadj
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Loss of bone mass is frequently identified in cirrhosis, leading to fragility fractures and significant morbidity. The pathogenesis is not completely elucidated. <h3>Objectives</h3> The aim of this study is to assess the prevalence of bone loss in cirrhotic patients and identify risk factors. <h3>Methods</h3> Bone mineral density (BMD) was performed in patients with cirrhosis seen in our department in 2011, by X-ray absorptiometry (DEXA) at both lumbar spine and femoral neck sites. Other diseases disturbing the bone density were excluded. Osteopenia was considered if T score &lt; -1.5 DS and osteoporosis if T-score &lt;-2.5 DS. We collected clinical data including risk factors for bone mass loss and nutritional status. <h3>Results</h3> Fifty patients with cirrhosis were included. They were 28 males and 22 females with a mean age of 54 years (17-84). Aetiology of cirrhosis was viral in 48% and auto-immune in 20%. Child-Pugh score was C in 32% and mean Meld score was 14 (5-32). BMD disclosed osteopenia in 32% and osteoporosis in 32%. Mean bone mass and T score were 0.94 kg/m<sup>2</sup> and -0.67 DS in femoral neck; 0.98 kg/m<sup>2</sup> and -1.2 DS in lumbar spine. History of fracture was present in 10% of cases. Low bone mass was correlated with female sex (p=0.01), age (p=0.04), sedentary (p=0.01) and Child Pugh C (p=0.03) but not with nutritional status. <h3>Conclusions</h3> In our study, prevalence of osteoporosis was 32%, as reported in Occident. Advanced liver disease in association with classical risk factors of osteoporosis was correlated with BMD. This high prevalence suggests that bone status should be evaluated routinely in patients with cirrhosis. <h3>Disclosure of Interest</h3> None Declared
Investment in Sure Start children’s centres is needed more than ever
Authors: Melisa C Campbell, Melissa Gladstone, Clare Oliver, Sophie Wickham, Ben Barr, Hanna Aisling, David Taylor-Robinson
Journal: BMJ (2016)

Torjensen highlights important new evidence that children’s centres are effective in improving children’s and families’ outcomes, and that funding cuts are having a negative impact on service provision.1 Department for Education research shows that these centres can improve …
Case 21-2006
Authors: Emad Eskandar, Fred G. Barker, James D. Rabinov
Journal: New England Journal of Medicine (2006)

A 61-year-old man was seen in the neurosurgery clinic because of facial pain. The pain had begun eight months earlier and was characterized by sharp paroxysms over the left side of the face that were brought on by the patient's eating or touching his moustache; there was a dull, throbbing pain in the same area. The neurologic examination was normal. A diagnostic and therapeutic procedure was performed.
SP0002 Early arthritis
Authors: I.B. McInnes
Journal: Annals of the Rheumatic Diseases (2013)

The last year has seen significant advances across a range of areas in the evaluation and treatment of early arthritis. In this review I will consider the key advances made in the last 12 months concerning understanding of the pathogenesis of early arthritis, management studies that inform clinical practice and finally the impact that such interventions may have on outcomes for patients. <h3>Disclosure of Interest</h3> None Declared
Clinical Use of Human Prothrombin Complexes
Authors: James L. Tullis, Marshall Melin, Paul Jurigian
Journal: New England Journal of Medicine (1965)

IN previous communications1 , 2 we have reported preliminary observations on the use of a prothrombin complex, factors II-VII-IX-X, prepared as an eluate from barium sulfate by the method of Surgenor et al.3 This report concerns clinical studies with such prothrombin preparations, combined with additional results obtained with a new, improved concentrate of prothrombin complex factors ( II, VII, IX and X) obtained by Chromatographic isolation from fresh human plasma by the method of Melin.4 A deficiency of one or more components of the prothrombin complex may complicate many clinical states: cirrhosis; hepatitis; biliary obstruction; malabsorption; childbirth; and the preoperative and postoperative . . .
Bilateral Cutaneous Diffuse Large B-Cell Lymphoma on FDG PET/CT
Authors: Ebuzer Kalender, Mustafa Yilmaz, Suna Erkilic, Mehmet Yilmaz, Zeki Celen
Journal: Clinical Nuclear Medicine (2011)

Primary cutaneous diffuse large B-cell lymphoma is an uncommon type of non-Hodgkin lymphomas. A 51-year-old man had 2 gradually enlarging reddish, firm, and painless cutaneous-subcutaneous masses surrounded with some erythematous patches on his back for 3 years. Skin biopsy result was consistent with diffuse large B-cell lymphoma. FDG PET/CT was performed for staging and demonstrated bilaterally increased FDG uptake in the cutaneous masses with hypermetabolic left axillary lymph nodes. After chemotherapy, FDG PET/CT demonstrated that all FDG-avid lesions resolved, and there is a complete response to therapy.
Epidemiology: Uncovering Clues To the Mysteries of Cancer
Authors: E. M. Newman, K. Smigel
Journal: JNCI Journal of the National Cancer Institute (1991)

Epidemiology: Uncovering Clues To the Mysteries of Cancer Get access E. Micheal Newman, E. Micheal Newman Search for other works by this author on: Oxford Academic PubMed Google Scholar Kara Smigel Kara Smigel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 11, 5 June 1991, Pages 746–748, https://doi.org/10.1093/jnci/83.11.746 Published: 05 June 1991
Characteristics in Youth Indicative of Adult-Onset Hodgkin's Disease23
Authors: Ralph S. Paffenbarger, Alvin L. Wing, Robert T. Hyde
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Characteristics in Youth Indicative of Adult-Onset Hodgkin's Disease Get access Ralph S. Paffenbarger, Jr., Ralph S. Paffenbarger, Jr. 6 6Address reprint requests to Dr. R. S. Paffenbarger, Jr., California State Department of Health, 2151 Berkeley Way, Berkeley, Calif. 94704. Search for other works by this author on: Oxford Academic PubMed Google Scholar Alvin L. Wing, Alvin L. Wing Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert T. Hyde Robert T. Hyde Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 5, May 1977, Pages 1489–1491, https://doi.org/10.1093/jnci/58.5.1489 Published: 01 May 1977 Article history Received: 09 July 1976 Accepted: 06 November 1976 Published: 01 May 1977
Navigating the Challenges of Fibrosis Assessment
Authors: Agnes B. Fogo, Charles E. Alpers
Journal: Journal of the American Society of Nephrology (2010)

Progression of chronic kidney disease at the tissue level is the result of accumulating extracellular matrix. This progression may be assessed by changes in GFR, but estimated GFR (eGFR) from serum creatinine is relatively inaccurate.[1][1],[2][2] Accurate assessment of parenchymal fibrosis is one
The Importance of a High-Pitched Squeaking Systolic Murmur in the Diagnosis of Aortic Stenosis and Calcification of the Aortic Valve
Authors: Harold A. Braun, Wilfrid J. Comeau
Journal: New England Journal of Medicine (1951)

THE primary purpose of this report is to emphasize the relation of a high-pitched "squeaking" or "musical" systolic murmur to aortic stenosis and calcification of the aortic valve. This is not so widely appreciated as it should be, for we have found that a high-pitched musical systolic murmur is more often attributed to obscure causes than to aortic valvular disease. Some writers1 , 2 even suggest that musical murmurs are not significant.It is rather surprising that this frequent and almost specific tonal quality of the murmur of aortic stenosis receives little emphasis in clinical teaching. No mention of it is found . . .
Bone Scan Manifestation of Transient Osteoporosis of the Hip
Authors: ALBERT J. MORENO, DAVID L. WARD
Journal: Clinical Nuclear Medicine (2001)

From the Department of Medicine, Nuclear Medicine Service, William Beaumont Army Medical Center, El Paso, Texas Received for publication January 10, 2001. Accepted February 19, 2001. The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the U.S. Department of the Army or the Department of Defense. Reprint requests: Albert J. Moreno, Nuclear Medicine Service, William Beaumont Army Medical Center, El Paso, Texas 79920–5001.
Bayes plus environment
Authors: Craig R. M. McKenzie
Journal: Behavioral and Brain Sciences (2009)

Abstract Oaksford &amp; Chater's (O&amp;C's) account of deductive reasoning is parsimonious at a local level (because a rational model is used to explain a wide range of behavior) and at a global level (because their Bayesian approach connects to other areas of research). Their emphasis on environmental structure is especially important, and the power of their approach is seen at both the computational and algorithmic levels.
SP0173 Are some osteoporosis treatments an option for osteoarthritis?
Authors: B.L. Langdahl
Journal: Annals of the Rheumatic Diseases (2013)

Osteoarthritis (OA) is the most common form of arthritis and the prevalence is increasing. The need for effective preventive and treatment measures are therefore urgent. OA is characterized by progressive degeneration of articular cartilage, synovitis and changes to the subchondral bone characterized by increased turnover, thinning of the trabecular structures, sclerosis of the subchondral plate, osteophytes and bone marrow lesions. Pain in OA is associated with synovitis and increased subchondral bone turnover. Based on these observations it has been suggested that drugs that either inhibit synovitis or bone turnover may have beneficial effects on already existing OA and/or be able to prevent the development of OA. Several antiresorptive therapies are available for the treatment of osteoporosis. Bisphosphonates, strontium ranelate and calcitonin have been investigated in clinical studies for their effect on progression of OA. The effects of bisphosphonates on OA have been investigated in two long-term prospective studies with effect on OA as primary endpoint. The BRISK study included 284 women with mild to moderate knee OA treated with risedronate (RIS) 15 mg daily for 12 months. Treatment with RIS resulted in improvement of the WOMAC index, particularly of physical function, and improvement in patient global assessment. Subsequently, a larger study, KOSTAR, was undertaken. 2483 patients with mild to moderate knee OA were included and randomized to different doses of RIS or placebo. Overall, no improvement in signs and symptoms of OA was observed and progression of OA was unaffected by treatment allocation. Serum levels of CTX-II were dose dependently decreased. Posthoc analyses revealed that more pronounced suppression of CTX-II was associated with less progression of the disease. A subgroup analysis of patients with progressive disease demonstrated that RIS preserves structural integrity of the subchondral bone. The effect of strontium ranelate (SR) on OA has been investigated in the TROPOS study, a study designed to examine the effect of SR on fracture prevention. SR reduced serum levels of CTX-II, a marker of cartilage degradation with 15-20% and deterioration of spinal OA with 42%. Back pain was reduced but there was no effect on health-related quality of life. Calcitonin has been demonstrated to reduce serum levels of CTX-II and improve functional disability despite no change in pain in patients with knee OA over 3 months. In order to further investigate the potential of antiresorptive treatments in prevention or treatment of OA, future research should be focused on 1. developing clinical relevant animal models, 2. identifying the pathogenic mechanisms that can be modified by intervention and 3. targeting pharmacological intervention towards those mechanisms in the right patients at the right time. <h3>Disclosure of Interest</h3> B. L. Langdahl Grant/Research support from: Amgen, Lilly, MSD, Consultant for: Amgen, Lilly, MSD, Nycomed, Speakers Bureau: Amgen, Lilly, GSK
Cholecystocolic Fistula of Crohn Disease Mimics Colon Adenocarcinoma Invasion of Gallbladder on F-18 FDG PET/CT
Authors: William Makis, Anthony Ciarallo, Jerome Laufer, Christopher Rush, Bin Xu
Journal: Clinical Nuclear Medicine (2011)

About one-third of patients with Crohn disease develop intra-abdominal fistulas, and of these, cholecystocolic fistulas are among the rarest. F-18 FDG PET/CT can detect a vast variety of fistulas, although most are discovered incidentally. We present a very unusual case of a 79-year-old woman referred for an F-18 FDG PET/CT for evaluation of a solitary pulmonary nodule. A colon mass was detected incidentally that appeared to directly invade the gallbladder; however, histologic evaluation after surgery revealed a colon adenocarcinoma, with an adjacent cholecystocolic fistula arising from a transmural fissure ulcer in a nonneoplastic colon segment consistent with clinically silent Crohn disease.
SAFETY OF EARLY DISCHARGE AFTER MINIMALIST TRANSCATHETER AORTIC VALVE REPLACEMENT
Authors: Jose Francisco Condado Contreras, Hanna A. Jensen, Vinod Thourani, Stamatios Lerakis, Kreton Mavromatis, Brian Kaebnick, Jose Binongo, Salim Hayek, Amjadullah Syed, Ayaz Rahman, Chandan Devireddy, Bradley Leshnower, Robert Guyton, Patricia Keegan, Amy Simone, James Stewart, Peter Block, Vasilis Babaliaros
Journal: Journal of the American College of Cardiology (2015)
A Controlled Trial of Colchicine in Preventing Attacks of Familial Mediterranean Fever
Authors: Deborah Zemer, Moshe Revach, Mordechai Pras, Baruch Modan, Stanley Schor, Ezra Sohar, Joseph Gafni
Journal: New England Journal of Medicine (1974)

A four-month, double-blind, crossover study of 22 patients with familial Mediterranean fever was undertaken to study the effect of colchicine in decreasing acute attacks of that disease. The regimen consisted of either 0.5 mg of colchicine or an identical-appearing placebo, twice daily for two months, followed by two additional months of the other treatment. Thus, each patient served as his own control. During the first two months of the study, the colchicine group experienced significantly fewer attacks (mean 1.15 per patient) than the placebo group (mean 5.25 per patient, p < 0.01). The patients who completed the crossover study had significantly fewer attacks on colchicine than on placebo (p < 0.01). The mean decrease in the number of attacks on colchicine was 3.85 for the two-month period. The study confirmed the advantage of colchicine in decreasing acute attacks of familial Mediterranean fever. (N Engl J Med 291:932–934, 1974)
Choledochoscopic radiofrequency ablation for congenital choledochal cysts
Authors: Fei Wang, Quanpeng Li, Xianxiu Ge, Hong Yu, Junjie Nie, Lin Miao
Journal: Endoscopy (2014)

A 47-year-old man with obstructive jaundice for 20 years consulted our hospital. Magnetic resonance cholangiopancreatography (MRCP) and endoscopic retrograde cholangiopancreatography (ERCP) demonstrated saccular dilatations of the intrahepatic and extrahepatic bile ducts ([Fig. 1]) and a type IV-A congenital choledochal cyst was diagnosed [1]. He underwent cyst excision of the dilated extrahepatic bile duct with a Roux-en-Y hepaticojejunostomy. Because a frozen section of the biopsy from the hilar bile duct showed high-grade intraepithelial neoplasia, a T-tube was inserted into the common hepatic duct.
Abstract 2805: A pooled investigation of circulating 25-hydroxyvitamin D and non-Hodgkin lymphoma: The Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
Authors: Mark P. Purdue, D. Michal Freedman, Susan M. Gapstur, Kathy J. Helzlsouer, Francine Laden, Unhee Lim, Gertraud Maskarinec, Nathaniel Rothman, Xiao-Ou Shu, Victoria L. Stevens, Anne Zeleniuch-Jacquotte, Demetrius Albanes, Kimberly Bertrand, Stephanie J. Weinstein, Kai Yu, Lonn Irish, Ronald L. Horst, Judith Hoffman Bolton, Edward L. Giovannucci, Laurence N. Kolonel, Kirk Snyder, Walter Willett, Alan A. Arslan, Richard B. Hayes, Wei Zheng, Yong Bing Zhang, Patricia Hartge
Journal: Cancer Research (2010)

Abstract Findings from several epidemiologic studies suggest that exposure to solar ultraviolet radiation may be associated with a reduced risk of non-Hodgkin lymphoma (NHL). These observations have led to speculation that vitamin D may protect against lymphomagenesis. To investigate this hypothesis, the authors conducted a pooled investigation of circulating 25-hydroxyvitamin D [25(OH)D] and subsequent NHL risk within ten cohorts participating in the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers. Prediagnostic samples of serum or plasma from 1,353 cases and 1,778 controls were assayed for 25(OH)D by immunoassay at a single laboratory. Odds ratios (ORs) and 95% confidence intervals (CIs) relating categories of 25(OH)D concentration with NHL risk were calculated using conditional logistic regression models, with 50-&amp;lt;75 nmol/L used as the reference category. Analyses of common NHL histologic subtypes were performed using polytomous regression modeling. Overall, no evidence of association with NHL risk was observed for either low 25(OH)D concentration (&amp;lt;25 nmol/L: OR 1.08, 95% CI 0.78-1.50) or high concentration (≥100 nmol/L: OR 0.86, 95% CI 0.57-1.27), and a test for trend was not statistically significant (P = 0.68). Analyses of other measures of 25(OH)D {continuous log[25(OH)D], categories of 25(OH)D using sex/cohort/season-specific cutpoints, categories of season-adjusted residuals of predicted 25(OH)D} were similarly null, as were results from stratified analyses and investigations of histologic subtypes of NHL. These findings do not support the hypothesis that elevated circulating 25(OH)D levels are associated with reduced NHL risk. Future research investigating the biologic basis for the sunlight-NHL association should consider alternative mechanisms, such as immunologic effects. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2805.