tbuckley/cabot-search huggingface dataset:
Abstract 3477: Graduate public health students as health educators: A pilot project to promote cancer health in Puerto Rico
Authors: Laura Moreno, Himilce Vélez, Julio Jiménez, Susan Vadaparampil, Teresita Muñoz-Antonia, José Torres, Gwendolyn Quinn
Journal: Cancer Research (2016)

Abstract Introduction: Community health workers, known as promotores de salud in Spanish, have been recognized as an effective communication channel to promote health education among marginalized groups. However, cancer education programs often cease efforts when funding ends. This can be particularly problematic in Puerto Rico (PR), where cancer is the leading cause of death. In an effort to identify new ways to provide sustainable cancer health education programs, the NCI-funded PACHE partnership between Moffitt Cancer Center and Ponce Health Sciences University (PSHU) trained graduate public health students to disseminate cancer education to PR communities. This was achieved by developing a culturally adapted version of “Cancer 101: A Cancer Education and Training Program” (Cancer 101) to the PR community. A pilot study was conducted to test students’ ability to: I) deliver the educational intervention, charlas, in the community; II) utilize a specific module from the curriculum, “Cancer in PR”, which focused on current island data and statistics, and definitions of the cancer and its various types; and III) to measure community members’ cancer knowledge before and after the charla. Methods: Students enrolled in the class Principles of Health Education in Practice (n = 15) participated in a two-day Cancer 101 training session. Upon completion, students were divided into 5 teams (n = 3 per team), each delivering the “Cancer in PR” charla to a community group of their selection. Cancer knowledge was assessed before and after the charla via a 10-item true or false questionnaire. Items were summed to create an overall knowledge score (range: 0-10). Results: A total of 201 participants attended the community educational intervention at 10 different locations in PR (Salinas Elderly, Guancha, Hogar San Jose, etc.). Participants pre and post-test mean score (SD) were 4.54 (2.31) and 7.65 (2.28) respectively, with a 3.1 (2.79) point increase in overall cancer knowledge (p&amp;lt;.000). Students reported the Cancer 101 toolkit was feasible and appropriate for each of the communities in which they delivered the intervention. Conclusion: Results from this pilot project suggest public health students are an innovative and sustainable way to improve cancer health communication and a novel strategy for reducing cancer health disparities. Citation Format: Laura Moreno, Himilce Vélez, Julio Jiménez, Susan Vadaparampil, Teresita Muñoz-Antonia, José Torres, Gwendolyn Quinn. Graduate public health students as health educators: A pilot project to promote cancer health in Puerto Rico. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 3477.
Comment on Fedorko et al. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016;39:392–399
Authors: Magnus Löndahl, Katarina Fagher, Per Katzman
Journal: Diabetes Care (2016)

More than 3 years after the last study visit, the study by Fedorko et al. (1) was published in Diabetes Care . Several issues need to be highlighted, some of which are discussed here.

If the end point “indication for [major] amputation” is more appropriate than “major amputation” (1), only the future can tell. Amputation rate assumption of 39.39 vs. 11.54% within a 3-month period in an outpatient care setting seems odd. Accordingly, amputation rates in the trial by Faglia et al. including hospitalized patients with severe and acute infected Wagner grade 3/4 ulcers were 9 vs. 33%, and the 1-year major amputation rate in the outpatient care studies by Abidia …
Abstract 10922: Relationship of the AHA Impact Goals (Life’s Simple 7) With Risk of Chronic Kidney Disease: Results From the ARIC Cohort Study
Authors: Casey M Rebholz, Cheryl A Anderson, Morgan E Grams, Lydia A Bazzano, Deidra C Crews, Alex R Chang, Josef Coresh, Lawrence J Appel
Journal: Circulation (2015)

Introduction: As part of its 2020 Impact Goals, the AHA developed the Life’s Simple 7 metric for cardiovascular health promotion. The metric consists of ideal categories for smoking, physical activity, diet, body mass index, blood pressure, blood cholesterol, and blood glucose; and its relationship with risk of chronic kidney disease (CKD) is unknown. Hypothesis: Ideal levels of health factors and the overall Life’s Simple 7 metric are associated with lower risk of developing CKD. Methods: We prospectively analyzed 15,436 Atherosclerosis Risk in Community study participants without CKD at baseline (1987-1989). Ideal levels of health factors were: non-smoker or quit &gt;1 year ago; body mass index &lt;25 kg/m 2 ; ≥150 minutes/week of physical activity; dietary pattern which is high in fruits and vegetables, fish, and fiber-rich whole grains, and low in sodium and sugar-sweetened beverages; total cholesterol &lt;200 mg/dL; blood pressure &lt;120/90 mmHg; and blood glucose &lt;100 mg/dL. Incident CKD was defined as development of estimated glomerular filtration rate &lt;60 mL/min/1.73 m 2 accompanied by 25% decline from baseline, hospitalization or death due to CKD, or end-stage renal disease defined by linkage with the U.S. Renal Data System. Cox regression was used to estimate associations between health factors, the overall metric, and CKD risk while adjusting for age, sex, race, and baseline kidney function. Results: At baseline, mean age was 54 years, 55% were women, and 26% were African-American. There were 2,861 incident CKD cases over a median follow-up of 22 years. Smoking, body mass index, physical activity, blood pressure, and blood glucose were associated with lower CKD risk (all p≤0.01), but diet and blood cholesterol were not. CKD risk was inversely related to the number of ideal health factors ( Figure ; p-trend&lt;0.001; AUC: 0.7001 vs. 0.6804, p&lt;0.001). Conclusions: The AHA Life’s Simple 7 metric, developed to measure and promote cardiovascular health, predicts reduced CKD risk.
Abstract 5170: Snail-dependent ESRP1 silencing drives malignant conversion of human pulmonary epithelial cells
Authors: Tonya C. Walser, Zhe Jing, Linh Tran, Ying Lin, Li Zhu, Sherven Sharma, Aik Ooi, Brigitte N. Gomperts, Jerry W. Shay, Jill E. Larsen, Boning Gao, John D. Minna, Micihael C. Fishbein, Steven M. Dubinett
Journal: Cancer Research (2016)

Abstract The significance of Snail expression in the early pathogenesis of non-small cell lung cancer has not been determined. Here, we report robust Snail expression in premalignant lung lesions relative to histologically normal-appearing pulmonary and lung cancer tissues. Utilizing immortalized human bronchial epithelial cells (HBECs) to isogenically model the contribution of the transcriptional repressor Snail to lung carcinogenesis, we document Snail-dependent anchorage-independent growth of pulmonary epithelial cells in vitro, as well as their transformation, primary tumor growth, and metastatic behavior in vivo. We delineate ESRP1 tumor suppressor silencing as a requirement for the Snail-driven transformation and identify ESRP1 silencing in Snail-expressing pulmonary premalignant lesions in situ. Utilizing this HBEC lung carcinogenesis model, we determined that Snail drives the expansion and malignant conversion of an ALDH+CD44+CD24- subset of pulmonary stem cells. Apoptosis-resistance and expression changes in oncogenes and tumor suppressors were noted, and ESRP1 was identified as a mediator of the malignant conversion of these Snail-primed pulmonary. Collectively, this is the initial report of a Snail-ESRP1-cancer axis that is operative during lung carcinogenesis and the first characterization of potentially targetable mediators of this normal to cancer continuum. Citation Format: Tonya C. Walser, Zhe Jing, Linh Tran, Ying Lin, Li Zhu, Sherven Sharma, Aik Ooi, Brigitte N. Gomperts, Jerry W. Shay, Jill E. Larsen, Boning Gao, John D. Minna, Micihael C. Fishbein, Steven M. Dubinett. Snail-dependent ESRP1 silencing drives malignant conversion of human pulmonary epithelial cells. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 5170.
Impact Of Total Nucleated Cell and CD34+ Cell Dose On Transplant Related Outcomes In Reduced Intensity Conditioning Allogeneic Hematopoietic Cell Transplants
Authors: Paul Martin, Shuli Li, Edwin P. Alyea, Vincent T. Ho, Corey S. Cutler, Philippe Armand, John Koreth, Chance J Luckey, Grace Kao, Jerome Ritz, Joseph H. Antin, Robert J. Soiffer
Journal: Blood (2013)
Lymphocyte:Monocyte Ratio At The Start Of Conditioning Regimen Is Associated With Survival Post-Autologous Stem Cell Transplantation (ASCT) For Lymphoma and Myeloma
Authors: Guilherme Fleury Perini, Alessandro de Moura Almeida, Erika MM Costa, Joyce E Hyppolito, Fabio Rodrigues Kerbauy, Nelson Hamerschlak, Fabio S P Santos
Journal: Blood (2013)
Understanding human immune function using the resources from the Human Functional Genomics Project
Authors: Mihai G Netea, Leo A B Joosten, Yang Li, Vinod Kumar, Marije Oosting, Sanne Smeekens, Martin Jaeger, Rob ter Horst, Melanie Schirmer, Hera Vlamakis, Richard Notebaart, Norman Pavelka, Raul Raul Aguirre-Gamboa, Morris A Swertz, Rahajeng N Tunjungputri, Wouter van de Heijden, Eric A Franzosa, Aylwin Ng, Daniel Graham, Kara Lassen, Kiki Schraa, Romana Netea-Maier, Jan Smit, Quirijn de Mast, Frank van de Veerdonk, Bart Jan Kullberg, Cees Tack, Inge van de Munckhof, Joost Rutten, Jacqueline van der Graaf, Lude Franke, Marten Hofker, Iris Jonkers, Mathieu Platteel, Astrid Maatman, Jingyuan Fu, Alexandra Zhernakova, Jos W M van der Meer, Charles A Dinarello, Andre van der Ven, Curtis Huttenhouwer, Hans Koenen, Irma Joosten, Ramnik J Xavier, Cisca Wijmenga
Journal: Nature Medicine (2016)
Association Between Intensive Care Unit Utilization During Hospitalization and Costs, Use of Invasive Procedures, and Mortality
Authors: Dong W. Chang, Martin F. Shapiro
Journal: JAMA Internal Medicine (2016)

Maximizing the value of critical care services requires understanding the relationship between intensive care unit (ICU) utilization, clinical outcomes, and costs.To examine whether hospitals had consistent patterns of ICU utilization across 4 common medical conditions and the association between higher use of the ICU and hospital costs, use of invasive procedures, and mortality.Retrospective cohort study of 156 842 hospitalizations in 94 acute-care nonfederal hospitals for diabetic ketoacidosis (DKA), pulmonary embolism (PE), upper gastrointestinal bleeding (UGIB), and congestive heart failure (CHF) in Washington state and Maryland from 2010 to 2012. Hospitalizations for DKA, PE, UGIB, and CHF were identified from the presence of compatible International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Multilevel logistic regression models were used to determine the predicted hospital-level ICU utilization during hospitalizations for the 4 study conditions. For each condition, hospitals were ranked based on the predicted ICU utilization rate to examine the variability in ICU utilization across institutions.The primary outcomes were associations between hospital-level ICU utilization rates and risk-adjusted hospital mortality, use of invasive procedures, and hospital costs.The 94 hospitals and 156 842 hospitalizations included in the study represented 4.7% of total hospitalizations in this study. ICU admission rates ranged from 16.3% to 81.2% for DKA, 5.0% to 44.2% for PE, 11.5% to 51.2% for UGIB, and 3.9% to 48.8% for CHF. Spearman rank coefficients between DKA, PE, UGIB, and CHF showed significant correlations in ICU utilization for these 4 medical conditions among hospitals (ρ ≥ 0.90 for all comparisons; P < .01 for all). For each condition, hospital-level ICU utilization rate was not associated with hospital mortality. Use of invasive procedures and costs of hospitalization were greater in institutions with higher ICU utilization for all 4 conditions.For medical conditions where ICU care is frequently provided, but may not always be necessary, institutions that utilize ICUs more frequently are more likely to perform invasive procedures and have higher costs but have no improvement in hospital mortality. Hospitals had similar ICU utilization patterns across the 4 medical conditions, suggesting that systematic institutional factors may influence decisions to potentially overutilize ICU care. Interventions that seek to improve the value of critical care services will need to address these factors that lead clinicians to admit patients to higher levels of care when equivalent care can be delivered elsewhere in the hospital.
Fam210b Is Required for Optimal Cellular and Mitochondrial Iron Uptake during Erythroid Differentiation
Authors: Yvette Y Yien, Caiyong Chen, Jiahai Shi, Liangtao Li, Daniel E. Bauer, Nicholas Huston, Paul D. Kingsley, Julien Ablain, Leonard I Zon, James Palis, Stuart H. Orkin, Jerry Kaplan, John D Phillips, Harvey F. Lodish, Barry Paw
Journal: Blood (2015)
Unilateral Suppression of Brown Fat on FDG PET/CT in Horner Syndrome
Authors: Gary A. Ulaner, Robert Samstein, Oren Cahlon, Wolfgang A. Weber, Andreas Rimner
Journal: Clinical Nuclear Medicine (2016)

A 29-year-old woman underwent resection of a left anterior mediastinal thymoma and pleurectomy. Postsurgical FDG PET/CT scan demonstrated FDG avidity in the right neck and upper thoracic fat but relatively absent FDG-avid fat in the left neck and upper thorax. Bilateral FDG-avid fat was also apparent in the lower chest and upper abdomen. After surgery, the patient demonstrated Horner syndrome, with left-sided ptosis, miosis, and facial anhidrosis. It is hypothesized that left-sided sympathetic nerves were compromised during surgery, leading to Horner syndrome and denervation of ipsilateral brown fat. The unilateral FDG avidity should not be mistaken for malignancy.
Abstract 560: Development of a novel class of traps that potently block transforming growth factor-beta (TGF-beta) thereby counteracting TGF-beta mediated immunosuppression and promoting T-cell infiltration into tumors
Authors: Maureen D. O’Connor-McCourt, Anne E.G. Lenferink, John Zwaagstra, Traian Sulea, Jason Baardsnes, Catherine Collins, Christiane Cantin, Yves Durocher, Renu Singh, James Koropatnick
Journal: Cancer Research (2016)

Abstract Introduction: Elevated TGF-β ligand markedly augments cancer progression primarily by suppressing the immune system in the tumor microenvironment, in particular by suppressing T-cell recruitment and/or activation. We developed a novel class of decoy receptor traps to potently block TGF- β and induce T-cell infiltration into tumors. This promotes the “T-cell-inflamed” tumor state, which is expected to render tumors sensitive to immune checkpoint inhibitors and other immunotherapeutics. Experimental Procedures: We have computationally designed a class of avidity-enhanced receptor-ectodomain-based traps which bind and neutralize TGF-β. Several trap formats have been produced and tested, with each format exhibiting varying characteristics, including differing circulating half-lives and in vitro blocking potencies (from nM to pM). Representative therapeutic candidates from the different trap formats were evaluated for efficacy in in vivo studies using the syngeneic 4T1 triple negative breast cancer (TNBC) tumor model. Additionally, ex vivo studies were performed on CD4+ and CD8+ T-cells harvested from the draining lymph nodes of treated animals. Results: In efficacy studies using the syngeneic 4T1 TNBC model, novel TGF-β traps were shown to promote significant T-cell infiltration into tumors. This infiltration resulted in reduced primary tumor growth as well as significant reductions in metastatic lesions. Additionally, ex vivo studies revealed that trap treatment decreased T-cell apoptosis, promoted T-cell proliferation in response to tumor cell lysates in the presence of dendritic cells, as well as increased the capacity of T-cells to specifically lyse 4T1 tumor cells. Conclusion: Novel computationally-designed TGF-β traps are capable of promoting the “T-cell-inflamed” tumor state. Combination studies in which this novel class of anti-TGF-β immunotherapy is combined with immune checkpoint inhibitors are ongoing. Citation Format: Maureen D. O’Connor-McCourt, Anne E.G. Lenferink, John Zwaagstra, Traian Sulea, Jason Baardsnes, Catherine Collins, Christiane Cantin, Yves Durocher, Renu Singh, James Koropatnick. Development of a novel class of traps that potently block transforming growth factor-beta (TGF-beta) thereby counteracting TGF-beta mediated immunosuppression and promoting T-cell infiltration into tumors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 560.
Digital next-generation sequencing identifies low-abundance mutations in pancreatic juice samples collected from the duodenum of patients with pancreatic cancer and intraductal papillary mucinous neoplasms
Authors: Jun Yu, Yoshihiko Sadakari, Koji Shindo, Masaya Suenaga, Aaron Brant, Jose Alejandro Navarro Almario, Michael Borges, Thomas Barkley, Shahriar Fesharakizadeh, Madeline Ford, Ralph H Hruban, Eun Ji Shin, Anne Marie Lennon, Marcia Irene Canto, Michael Goggins
Journal: Gut (2016)

<h3>Objective</h3> Secretin-stimulated pancreatic juice contains DNA shed from cells lining the pancreatic ducts. Genetic analysis of this fluid may form a test to detect pancreatic ductal neoplasia. <h3>Design</h3> We employed digital next-generation sequencing (‘digital NGS’) to detect low-abundance mutations in secretin-stimulated juice samples collected from the duodenum of subjects enrolled in Cancer of the Pancreas Screening studies at Johns Hopkins Hospital. For each juice sample, digital NGS necessitated 96 NGS reactions sequencing nine genes. The study population included 115 subjects (53 discovery, 62 validation) (1) with pancreatic ductal adenocarcinoma (PDAC), (2) intraductal papillary mucinous neoplasm (IPMN), (3) controls with non-suspicious pancreata. <h3>Results</h3> Cases with PDAC and IPMN were more likely to have mutant DNA detected in pancreatic juice than controls (both p&lt;0.0001); mutant DNA concentrations were higher in patients with PDAC than IPMN (p=0.003) or controls (p&lt;0.001). <i>TP53</i> and/or <i>SMAD4</i> mutations were commonly detected in juice samples from patients with PDAC and were not detected in controls (p&lt;0.0001); mutant <i>TP53</i>/<i>SMAD4</i> concentrations could distinguish PDAC from IPMN cases with 32.4% sensitivity, 100% specificity (area under the curve, AUC 0.73, p=0.0002) and controls (AUC 0.82, p&lt;0.0001). Two of four patients who developed pancreatic cancer despite close surveillance had <i>SMAD4/TP53</i> mutations from their cancer detected in juice samples collected over 1 year prior to their pancreatic cancer diagnosis when no suspicious pancreatic lesions were detected by imaging. <h3>Conclusions</h3> The detection in pancreatic juice of mutations important for the progression of low-grade dysplasia to high-grade dysplasia and invasive pancreatic cancer may improve the management of patients undergoing pancreatic screening and surveillance.
Genomic analysis of 6,000-year-old cultivated grain illuminates the domestication history of barley
Authors: Martin Mascher, Verena J Schuenemann, Uri Davidovich, Nimrod Marom, Axel Himmelbach, Sariel Hübner, Abraham Korol, Michal David, Ella Reiter, Simone Riehl, Mona Schreiber, Samuel H Vohr, Richard E Green, Ian K Dawson, Joanne Russell, Benjamin Kilian, Gary J Muehlbauer, Robbie Waugh, Tzion Fahima, Johannes Krause, Ehud Weiss, Nils Stein
Journal: Nature Genetics (2016)
High-Resolution Genomic Methylation Analysis Using Next Generation Sequencing Identifies Loci Associated With Differential Prognosis In Mantle Cell Lymphoma Patients Treated With Bortezomib + DA-EPOCH-R
Authors: Violetta V. Leshchenko, Pei-Yu Kuo, Deepak Perumal, Melissa J Fazzari, Francine E. Garrett-Bakelman, Nakhle S Saba, Delong Liu, Weijia Zhang, Joshua Brody, Ari M. Melnick, Kieron Dunleavy, Wyndham H Wilson, Adrian Wiestner, Samir Parekh
Journal: Blood (2013)
Abstract 4732: A novel analog of Leonurine inhibits melanoma growth and survival through STAT3 signaling pathways
Authors: Manoj K. Pandey, Jacek Krzeminski, Deepkamal Karelia, Arun K. Sharma, Shantu G. Amin
Journal: Cancer Research (2016)

Abstract Previous studies have shown that a major alkaloid of Leonurus japonicus Houtt, Leonurine, displays a variety of biological effects including inhibition of HMG-CoA reductase, kidney fibrosis, and osteoporosis. However, the full potential of this alkaloid as a cancer therapeutics has not been explored, primarily due to the lack of potency. A limited reports however, do suggest that Leonurine induces apoptosis in lung and liver cancer cells. We hypothesized that this natural product's structure can be optimized to create a more potent and drug-like molecule. A recent structure-activity relationship (SAR) study in our laboratory based on Leonurine structure has led to the identification of three novel analogs which were &amp;gt;100 times potent than Leonurine in killing solid cancer cells. The aim of the current study is to determine whether the novel analogs of Leonurine exhibit anti-proliferative effects against tumor cells through suppression of the signal transducer and activator of transcription 3 (STAT3) activation pathway. We investigated the effects of Leonurine analogs on constitutive STAT3 activation, modulation of tyrosine kinases and phosphatases in STAT3 activation, STAT3-regulated gene products, and growth modulation of tumor cells. We found that these compounds inhibited constitutive STAT3 activation in metastatic melanoma cells. The suppression was mediated through the inhibition of activation of the upstream kinases Janus-like kinase (JAK) 1, and JAK2. Leonurine derivatives down-regulated the expression of STAT3-regulated gene products such as survivin, Bcl-xL, Bcl-2, cyclin D1, and Mcl-1 leading to the suppression of proliferation and induction of apoptosis. Moreover, we found that these Leonurine analogs significantly inhibited the proliferation of variety of cells derived from solid tumors including breast, pancreatic, prostate, and colon cancer. Overall, these results suggest that these new compounds are novel blockers of STAT3 activation and thus may have potential to suppress melanoma cell proliferation and chemoresistance. Citation Format: Manoj K. Pandey, Jacek Krzeminski, Deepkamal Karelia, Arun K. Sharma, Shantu G. Amin. A novel analog of Leonurine inhibits melanoma growth and survival through STAT3 signaling pathways. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 4732.