tbuckley/cabot-search huggingface dataset:
SAT0199 Diagnosis of Early Rheumatoid Arthritis: is There A Best Classification Criteria?
Authors: M.O. Perez, L. Aquila, A.C. Medeiros, K. Bonfiglioli, D. Domiciano, L.N. Guedes, C.R. Gonçalves, I.M.M. Laurindo
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Early diagnosis and treatmente of rheumatoid arthritis (RA) involves better outcomes and prognosis. It is still arguable the best classification criteria of early RA. <h3>Objectives</h3> To evaluate, using three different classification criteria, the presence of early RA in patients with arthritis, and its evolution over a period of 10 years. <h3>Methods</h3> 59 patients with early arthritis (less than 12 months of symptons) followed for a period of 10 years (2003-2013) were selected from the Early Arthritis Clinic of the rheumatology service. Retrospectively, we applied the ACR (1987), criteria, the ACR/EULAR (2010), and the Huizinga criteria (2007). Mann-Whitney and Fisher tests were applied as needed. P&lt;0.05 was considered significant. <h3>Results</h3> 49 women (83%) and 10 men (17%), mean age of 47±12.43 and arthritis average onset of 3.2±5.47 months were included. A total of 44 patients (74%) were retrospectively diagnosed as RA: 6 (13%) only according to the ACR-1987), another 6 (13%) only according to ACR 2010, 1 (2%) only according with the Huizinga criteria while 23 (52%) fulfilled the three criteria. Of the 44 patients initially considered as early RA, 5 (11%) had other definitive diagnoses after 10 years of follow-up (3 osteoarthritis, 1 psoriatic arthritis, and 1 spondylitis). From those who were not diagnosed initially with RA (15), only 3 received this diagnosis during follow-up. Comparatively, the most sensitive criteria was the ACR 1987 (S: 78.6%, E: 88.2%, NPV: 62.5%, PPV: 94.3%) and the most specific was the Huizinga criteria (S: 61,9%, E: 96%, NPV: 60%, PPV: 96.3%). However, ACR (1987) was more specific when added to anti-CCP (S: 80%, E: 93%, NPV: 79%, PPV: 94%). After 10 years of follow up, 12 (30.76%) patients were in remission, 4 (10.25%) with control of disease, 10 (25.6%) with active disease and 13 (33.3%) were using biologic agents. Anti-CCP was a good predictor of biologic prescription (p: 0.006). <h3>Conclusions</h3> Diagnosis of early RA is not straightforward and other diagnoses are not easily excluded. ACR-1987 criteria was more sensitive and Huizinga criteria was more specific for the diagnosis of early RA. However, in our study, the best performance was observed when anti-CCP test was added to ACR-1987. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5522
Abstract 498: MicroRNA200c attenuated metastatic abilities in head and neck squamous cell carcinoma-derived cancer cells
Authors: Shih-Hwa Chiou, Kuan-Hsuan Chen, Wen-Liang Lo, Yi-Wei Chen, Yu-Chih Chen
Journal: Cancer Research (2011)

Abstract MicroRNA-200c (miR200c) is emerging as an important regulator of epithelial-mesenchymal transition (EMT), tumorigenicity and cancer metastasis. Recent investigation showed miR200c can regulate the stemness in breast cancer stem cell through directly binding the 3’UTR of Bmi1. However, the role of miR200c in head and neck squamous cell carcinoma (HNSCC) and HNSCC-associated CSC has never been determined. In this study, we first demonstrated that miR200c expression was significantly decreased but Bmi1 expression was increased in HNSCC tissues as compared to adjacent normal cells. Secondly, HNSCC-ALDH1+CD44+ cells presented tumor initiating and radioresistant properties with high EMT. Consistently, the Bmi1 expression was significantly up-regulated and miR200c was down-regulated in HNSCC-ALDH1+CD44+ compared to other isolated subsets of HNSCC cells. Furthermore, miR-200c overexpression or Bmi1 knockdown through lentiviral infection could significantly inhibit the clonogenic and invasive abilities of HNSCC-ALDH1+CD44+ cells. Moreover, overexpression of Bmi-1 promoted HNSCC-ALDH1−CD44− to acquire CSC properties which are similar to HNSCC-ALDH1+CD44+. In contrast, overexpressing of miR200c shifted transcriptomes profiles of ALDH1+CD44+ similar to those of ALDH1-/CD44- populations and abolished self-renewal as well as EMT properties in ALDH1+CD44+. Most importantly, overexpression of miR-200c in ALDH1+CD44+ or ALDH1−CD44−Bmi-1over cells effectively blocked tumor growth and lung metastasis, and significantly prolonged survival time in neck orthotropic-transplanted immunocompromised mice. Lastly, miR200c is significantly reduced in high grade, metastatic HNSCC tissues compared to low-grade HNSCC tissues. In sum, these results show that miR200c negatively modulates Bmi1 expression and plays a role as a tumor suppressor in HNSCC through eliminating HNSCC-CSC population. Restoration of miR200c in HNSCC and CSC may pave a new approach for therapeutic treatment in the future. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 498. doi:10.1158/1538-7445.AM2011-498
ANTIBODY LABELING WITH A RADIOIODINATED INTRACELLULARITY TRAPPED LIGAND-TYRAMINECELLOBIOSE (TCB).
Authors: S. A. Ali, J. F. Eary, C. C. Badger, K. Y. Richter, K. A. Krohn, W. B. Nelp
Journal: Clinical Nuclear Medicine (1987)

Ali, S. A.; Eary, J. F.; Badger, C. C.; Richter, K. Y.; Krohn, K. A.; Nelp, W. B. Author Information
Abstract P4-01-07: The Relationship of Breast Density in Mammography and Magnetic Resonance (MR) Imaging in a High Risk Population
Authors: J Chun, AP Refinetti, F Schnabel, AP Leite, A Price, J Billig, S Schwartz, L Moy
Journal: Cancer Research (2012)

Abstract Background: Mammographic breast density (BD) is associated with a 4 to 6-fold increased risk for developing breast cancer. Increased breast density on mammography is also known to decrease the diagnostic sensitivity of the exam, which is of great concern to women at increased risk for breast cancer. There is well-established medical literature describing the benefit of MRI in screening high risk women. A previous study has shown that background parenchymal enhancement (BPE) as measured on MRI can be correlated with breast cancer risk. The purpose of this study was to evaluate the relationship between BD, BPE, and FGT (assessment of the amount of fibroglandular tissue with contiguous MR images through both breasts) in pre and post-menopausal women who are at high risk for developing breast cancer. Methods: The High Risk Breast Cancer Consortium (HRBCC) database at NYU Langone Medical Center was queried for our study population. A total of 56 women had both screening mammograms and MRIs completed at our center. Variables of interest included BD, BPE, FGT, BMI, Gail scores, and menopausal status. BD was defined by ACR classifications 1–4. FGT was assessed on a similar scale 1–4. BPE was categorized as minimal, mild, moderate, or marked. BMI (kg/m2) was grouped into 4 categories: underweight (≤18), normal (19–24), overweight (25–29), and obese (≥30). Statistical analyses were performed using Spearman Correlation Coefficients. Results: The median age in our cohort was 48 years (range 24–70 years). The majority of women were Caucasian (74%) with a median 5-year Gail score of 3.35. There was no correlation between BD and BPE (r = 0.08) and BPE and FGT (r = 0.18). However, there was a moderate positive correlation between BD and FGT (r = 0.65). When we stratified by menopausal status, the correlation for BD and FGT was stronger for post-menopausal women (r = 0.73) versus premenopausal women (r = 0.57). When we stratified by BMI, we found a stronger positive association for BD and FGT among women who were overweight and obese (r = 0.62). Conclusions: In our study cohort of patients at high risk for developing breast cancer, BD and BPE were not correlated, even after adjusting for menopausal status. This implies that BD and BPE may represent different characteristics of breast tissue and may have different implications. We found a strong correlation between BD and FGT. This association was strongest in women who were overweight and obese. FGT is a more objective and quantitative measurement of breast density and may be more useful in quantitative breast cancer risk assessment. Further studies are necessary to determine if BPE and FGT are independent risk factors for breast cancer. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-01-07.
The relation of ulcerative colitis to psychiatric factors: a review of findings and methods
Authors: C S North, R E Clouse, E L Spitznagel, D H Alpers
Journal: American Journal of Psychiatry (1990)

The authors reviewed all known English-language literature on the association between psychiatric factors and ulcerative colitis to ascertain the evidence for such an association and evaluate the methods used in these studies. Most of the 138 studies contained serious flaws in research design, such as lack of control subjects, unspecified manner of data collection, and absence of diagnostic criteria. Analysis revealed that methodological flaws were significantly related to the finding of a positive association between psychiatric factors and ulcerative colitis. Seven studies represented solid systematic investigation, and all seven failed to find such an association.
Abstract 1128: The tumor suppressive function of Merlin/Nf2 is mediated by a novel tight junction-associated protein complex
Authors: Chunling Yi, Joseph Kissil
Journal: Cancer Research (2010)

Abstract Mutations in the NF2 tumor suppressor gene lead to inherited cancer-disorder Neurofibromatosis Type 2 (NF2) and other sporadic nerve-sheath tumors. Merlin, the protein product of the NF2 gene, suppresses cell proliferation and tumorigenesis by regulating multiple signaling pathways including the Ras-MAPK pathway. Through affinity purification, we have identified a novel tight-junction-associated protein complex comprising Merlin and a number of tight junction associated proteins. We show that Merlin directly interacts and co-localizes with one of these tight junction proteins through their mutual coiled-coil domains in epithelial and Schwann cells. Furthermore, the two proteins co-localize to paranodes and Schmidt-Lantermann incisures in myelinated peripheral nerve, the most frequent site of tumor development caused by Nf2 inactivation. We establish that the novel Merlin-binding protein functions downstream of Merlin as a positive regulator of Rac1 activity and the Ras-MAPK signaling. Importantly, we are able to demonstrate that depletion of this Merlin-interacting protein in Nf2-/- schwannoma cells down-regulates the Ras-MAPK signaling pathway, and impedes cellular proliferation in vitro and tumor development in vivo. Taken together with our observations that several NF2 patient-derived mutant Merlin proteins exhibit diminished association with this protein and that its level is elevated in 9 out of 10 human schwannoma samples examined, we conclude that the novel Merlin-binding partner identified in this study mediates the tumor suppressive function of Merlin and represents a potential therapeutic target for NF2 related tumors. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1128.
PWE-143 Sequential Oral Anti-Viral Therapy Following Pegylated-Interferon-Alpha Failure Significantly Increases Hbsag Decline
Authors: U S Gill, L Payaniandy, J Schulz, D Payaniandy, V Ross, Y Kallis, P Kooner, R Marley, G R Foster, P T Kennedy
Journal: Gut (2013)

<h3>Introduction</h3> Tenofovir and Entecavir are potent oral antivirals (OAV’s) and leading agents in the treatment of Chronic Hepatitis B (CHB). Despite this, they have limited ability to reduce HBsAg, thus indefinite or life-long therapy is mandated as these drugs rarely achieve immunological control. Pegylated-Interferon-Alpha (PEG-IFNα) is associated with better rates of HBsAg decline, but only a minority of patients achieve sustained immune control. New strategies to reduce HBsAg and achieve immune control, including combination PEG-IFNα &amp; OAV are under investigation at present. Here we report data on treatment response in a cohort receiving sequential OAV therapy following PEG-IFNα failure. <h3>Methods</h3> 55 patients (male = 41), median age 31 (range 18–55) were treated with PEG-IFNα over the course of the study. 13 patients remain on therapy and 5 patients discontinued due to poor response or intolerance. 37 patients, HBeAg positive (n = 29), completed 48 weeks PEG-IFNα and were included in the analysis. 23/37 patients (HBeAg positive = 18), following treatment with PEG-IFNα were considered non-responders and treated with sequential OAV therapy. Treatment response in this cohort was compared with 60 patients, (male = 54), median age 45 (range 21–70) receiving OAV monotherapy over a 12-month period. Serum ALT, HBV DNA and HBsAg were quantified at baseline and longitudinally in both cohorts. <h3>Results</h3> In the sequential therapy group, baseline median ALT was 60 IU/L (range 31–194) and median HBV DNA 5.15 logIU/ml compared with 43 IU/L and 3.43 logIU/ml respectively for the OAV monotherapy group. ALT normalisation and reduction in HBV DNA to undetectable levels was similar in both groups over follow-up (p- = n.s). Following 12-months of OAV monotherapy the decline in HBsAg in this group overall was 0.06 logIU/ml compared to baseline (p = n.s). In patients receiving sequential OAV therapy there was a significant decline in HBsAg over follow-up compared to baseline (0.65 log IU/ml, p = 0.0001). In addition 4/18 HBeAg positive patients seroconverted on sequential therapy and 1 patient cleared HBsAg. <h3>Conclusion</h3> Sequential OAV therapy following treatment failure with PEG-IFNα is associated with greater reductions of HBsAg than PEG-IFNα alone or OAV monotherapy. This suggests PEG-IFNα may prime the immune response, even in the context of treatment failure, leading to better responses with sequential OAV therapy. Further studies are needed to confirm this finding and determine whether a similar priming effect is observed with shorter courses of PEG-IFNα in line with current PEG-IFNα stopping rules. <h3>Disclosure of Interest</h3> None Declared.
Excessive Obesity in Offspring of Pima Indian Women with Diabetes during Pregnancy
Authors: David J. Pettitt, H. Robert Baird, Kirk A. Aleck, Peter H. Bennett, William C. Knowler
Journal: New England Journal of Medicine (1983)

We studied the relation in Pima Indians between obesity in children and diabetes during pregnancy in their mothers. Sixty-eight children of 49 women who had had diabetes during pregnancy had a higher prevalence of obesity than 541 children of 134 women who subsequently had diabetes (prediabetics) or than 1326 children of 446 women who remained nondiabetic. At 15 to 19 years of age, 58 per cent of the offspring of diabetics weighed 140 per cent or more of their desirable weight, as compared with 17 per cent of the offspring of nondiabetics and 25 per cent of those of prediabetics (P less than 0.001). Obesity in the offspring was directly related to maternal diabetes, since the association was not substantially confounded by maternal obesity. The findings strongly suggest that the prenatal environment of the offspring of diabetic women results in the development of obesity in childhood and early adulthood.
PARE0006 Patient empowerment, learning, relaxing, fun, public awareness: a project in the austrian alps
Authors: P. Wegscheider, G. Schaffer
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Patient support groups provide information about rheumatic diseases in order to improve the quality of lives through education and self-management programs, help to get in contact to professional health care and support sharing experiences. Another aim is to raise awareness of the needs of people with arthritis/rheumatism. The Austrian Rheumatism League allocates these and arranges meetings for patients with inflammatory and non-inflammatory rheumatic diseases. <h3>Objectives</h3> In summer 2012 a four day meeting in Maria Alm, Salzburg, Austria was organized for patients and health care professionals in order to inform patients about their diseases. <h3>Methods</h3> The Austrian Rheumatism League organized a meeting for patients and health care professionals (including physicians, occupational therapists, physical therapists, Qigong-teachers) for four days in the Salzburger Alps. Presentations covering topics like "Is it really arthritis", "Rheumatism in the elderly", "Non-medicamentous pain therapy", "Patient-doctors-relationship", "Infrared therapy" and "Back pain" were held. Interactive workshops on Qigong, drumming and sounds, climbing for patients with rheumatism, gymnastic exercises, cookery courses for arthritis patients, joint protection were performed. A guided herb walk followed by the preparation of herbs for eating and cosmetics was organised as well. <h3>Results</h3> Participants emphasized the informal and social aspects of the meeting as an important factor for self-management of their disease. The combination of learning, relaxing and movement were beneficial for a positive result of the lectures. Furthermore the possibility to exchange personal experience was important. All participants, who filled in the questionnaire, graded the project with "very good". Gymnastic exercises and exercises for recreation were graded with "very good" from 69% of the people. 62% of all patients learned a lot of new facts about rheumatism through oral presentations. The lecture about coping strategies was graded with "very good" of 32% and with "good" of 54%. 85% of the participants were diagnosed with arthritis (rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis), 69% were diagnosed with osteoarthritis, and some of them were diagnosed with both. <h3>Conclusions</h3> Following the positive feedback the Austrian Rheumatism League intends to organize special meetings every year to get new participants, to get public awareness and to present recentpatients coping strategies. <h3>Disclosure of Interest</h3> None Declared
The Emerging Pattern of Urban Histoplasmosis
Authors: M. L. Furcolow, F. E. Tosh, H. W. Larsh, H. J. Lynch, G. Shaw
Journal: New England Journal of Medicine (1961)

URBAN children, because of their more localized environment and less frequent exposure, appear to be more suitable subjects than rural children for studies of the acquisition of infection with Histoplasma capsulatum.1 , 2 In these papers two sources of infection among urban children were reported: visits to farms or prior rural residence and exposure in urban structures contaminated with bird droppings. Kier et al.3 have reported a third source — importation of contaminated farm soil or manure as fertilizer. In the present paper we wish to call attention to a fourth source of infection among urban children — namely, infection in wooded, . . .
AB0975 Quality of life in women suffering from knee osteoarthritis:
Authors: I. Ben Slama, H. Rkain, L. Traki, I. Bouaddi, L. Bouazzaoui, F. Allali, N. Hajjaj Hassouni
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> to evaluate the quality of life in women suffering from knee osteoarthritis, Consecutive outpatients consulting for primary knee OA were included in this cross sectional study. This study suggests a high impact of knee OA on all aspects of quality of live in women. <h3>Objectives</h3> We aimed to investigate the impact of knee osteoarthritis (OA) on the quality of life (QoL) in moroccan women patients with non-end-stage knee osteoarthritis. We suggest also to search possible factors associated with to health related QoL. <h3>Methods</h3> Patients consulting for primary knee OA were included. Most patients had an interviewer-administrated questionnaire. Functional status was assessed by womac and lequesne and QoL with the Moroccan version of OAKHQOL. Relationship between patients and disease features and the different domains of the OAKHQOL was evaluated by using Spearmann Correlation. The significant factors of related to the OAKHQOL were analyzed by a forward stepwise multiple regression model. <b>Results:</b> Multiple linear regression models have shown that only WOMAC (-5.4 [-1.2-0.5]; p&lt;0.001) and lequesne (3,1 [-1,2-4,9]; p&lt;0.02) were significant independent factors related to QoL. <h3>Conclusions</h3> This study suggests a high impact of knee OA on all aspects of quality of live in women especially: physical activities, social support and social functioning. These disturbances re associated to poor functional status. Domains affected should be taken into account order to improve QoL in women with OA. These results should be confirmed by larger studies. <h3>Disclosure of Interest</h3> None Declared
Commentary: Oncogene Activation in Experimental Carcinogenesis: The Role of Carcinogen and Tissue Specificity
Authors: Seymour J. Garte, Anne E. Hochwalt
Journal: Environmental Health Perspectives (1989)

Techniques of molecular biology have been used to determine the relationship of cellular oncogenes to mechanisms of experimental carcinogenesis.Model systems involving three direct-acting alkylating carcino- gens, two organ sites, and two species have been employed to elucidate the relationships between carcino- genic etiology, tissue specificity, and activation of known and novel oncogenes.Dimethylcarbamyl chloride, a reactive acylating agent, induces tumors of both the rat nasal mucosa and mouse skin whose DNA is de- void of NIH 3T3 transforming activity.P-propiolactone-induced rat nasal carcinomas contain a novel oncogene, 6 to 9 kb in size, whereas a mouse skin carcinoma induced by this agent possesses an H-ras oncogene acti- vated by a 61st codon A to T transversion mutation.The novel oncogene activated in rat nasal tumors in- duced by P-propiolactone is distinct from one found in methylmethane sulfonate-induced tumors.The im- plications of these findings for understanding how oncogenes fit into general mechanism of carcinogenesis are discussed.