tbuckley/cabot-search huggingface dataset:
Association of obesity with cytogenetic risk in adult acute myeloid leukemia (AML).
Authors: Laura Elizabeth Finn, Lisa Ostrosky Sproat, Michael Heckman, Liuyan Jiang, Nancy N. Diehl, Rhett P. Ketterling, Riccardo Valdez, James M. Foran
Journal: Journal of Clinical Oncology (2014)

7055 Background: Obesity, body mass index (BMI) ≥30 kg/m2, is a risk factor for several malignancies. Prospective studies have reported a positive association between obesity and adult leukemia. The association between obesity and AML cytogenetic risk groups is unknown. We therefore evaluated a cohort of 295 AML patients with confirmed cytogenetics analysis diagnosed and treated at Mayo Clinic Florida and Arizona since 1995. Methods: Documented patient characteristics including height and weight, past medical history, medications, cytogenetics, treatments, and outcomes regarding their diagnosis of AML were extracted from a central electronic medical record. Standard cytogenetic risk categories (including intermediate abnormal) were applied. The association of obesity with cytogenetic risk was evaluated on multivariable analysis using logistic regression models. Results: The median BMI was 26.9 kg/m2 (range 16.9-59.9). 82 patients (28%) in the evaluated cohort were obese. On multivariable analysis obesity had the most significant association with intermediate-abnormal cytogenetics in comparison to additional patient factors evaluated including patient age, secondary AML (sAML), and therapy related AML (tAML). Obesity did not significantly impact remission after induction chemotherapy or survival after AML diagnosis. Conclusions: Obesity is significantly associated with intermediate abnormal risk cytogenetics in AML. This supports a link to leukemogenesis and requires validation in a larger controlled prospective therapeutic study. Variable Cytogenetic risk (OR; 95% CI) N Poor Intermediate-abnormal Intermediate-normal Age >60 222 0.69 (0.38,1.24) P=0.21 1.40 (0.71,2.75) p=0.33 1.29 (0.72,2.31) p=0.39 BMI ≥ 30 82 0.79 (0.45,1.40) p=0.42 1.95 (1.09,3.50) p=0.024 0.76 (0.44,1.32) p=0.33 tAML 43 1.36 (0.70,2.64) p=0.37 1.39 (0.67,2.88) p=0.38 0.38 (0.17,0.83) p=0.015 sAML 119 2.13 (1.30,3.49) p=0.003 0.85 (0.48,1.49) p=0.57 0.73 (0.45,1.19) p=0.21 Complete remission after induction chemotherapy (OR; 95% CI) Variable Single variable analysis Multivariable analysis BMI ≥ 30 1.02 (0.53,1.97) p=0.95 0.94 (0.47,1.89) p=0.87 Survival after AML diagnosis (RR; 95%CI) BMI ≥ 30 1.14 (0.85, 1.52) p=0.38
Adverse Effects of Proton Pump Inhibitors in Chronic Kidney Disease—Reply
Authors: Benjamin Lazarus, Josef Coresh, Morgan E. Grams
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Marked Response to 177Lu Prostate-Specific Membrane Antigen Treatment in Patient With Metastatic Prostate Cancer
Authors: Cigdem Soydal, Elgin Ozkan, Serap Akyurek, Nuriye Ozlem Kucuk
Journal: Clinical Nuclear Medicine (2015)

We present pretreatment Ga prostate-specific membrane antigen (PSMA) PET/CT and posttreatment Lu-PSMA whole-body scintigraphy images of a 60-year-old patient with metastatic prostate cancer who is dramatically responding to Lu-PSMA treatment.
Measles in Germany
Authors: E Gericke, Gernot Rasch, A Tischer, S Santibanez
Journal: Eurosurveillance (1997)

Experts met in Copenhagen on 19 and 20 November 1996 to discuss the elimination of measles in Europe. European countries were assigned to four different categories on the basis of a recent survey conducted by the World Health Organization&#39;s Regional Offic
PWE-342 Evaluation of fobt-positive individuals not undergoing colonoscopy in the bowel screening programme
Authors: A Gemmell, P Phull
Journal: Gut (2015)

<h3>Introduction</h3> In the UK, population based colorectal cancer (CRC) screening is conducted based on biennial faecal occult blood testing (FOBT), with follow-up colonoscopy for positive results. However, a proportion of FOBT-positive subjects do not undergo colonoscopy, due to individual choice, comorbidity or current/recent colonic investigations for symptoms. The aim of this study was to evaluate this group of FOBT screen-positive subjects who do not undergo a screening colonoscopy. <h3>Method</h3> Retrospective audit of prospectively collected data within the North East Scotland bowel screening database, between 1/06/2007 to 31/05/2013. Data was collected for reasons why colonoscopy was not performed, as well as the performance and results of further alternative imaging. <h3>Results</h3> During the 6 year period of the audit, 4975 screening colonoscopy referrals were received for 4704 individuals (253 subjects had presented through 2 rounds and 18 through 3 rounds of the screening programme). Overall, 1081 (21.73%) referrals did not have a colonoscopy performed; 492 (45.5%) declined, a clinical decision was made in 525 (48.6%), 46 (4.3%) were under surveillance, 14 (1.3%) did not attend the appointment, 2 (0.01%) individuals died and no reason was identified in 2 cases. Of the 492 subjects that declined colonoscopy, 36 (7.3%) had the procedure performed in the private sector, other reasons were recorded in 34 (6.9%) cases and no reason was recorded for the remaining subjects. Of the 525 cases in whom a clinical decision was made not to perform colonoscopy, the reasons were recorded as significant co-morbidity in 159 (30.3%) with 25 (4.8%) cases of cancer, 151 (28.8%) subjects had colonic imaging within the previous 12 months, 26 (5%) had active IBD, 118 (22.5%) were in the symptomatic service with a colonoscopy appointment already arranged, 12 (2.3%) individuals had previous failed colonoscopies on &gt;1 occasion, and other/no reason was recorded in 59 (11.2%) subjects. Radiological colonic imaging (as an alternative to colonoscopy) was performed in 109 subjects: 38 CT colonography, 32 barium enema and 41 minimal-preparation CT scan abdomen/pelvis. Twelve cases of colorectal cancer were diagnosed in this group. <h3>Conclusion</h3> The major reasons for screening colonoscopy not being performed are individuals declining or a clinical decision, with co-morbidity a major factor. Radiological imaging in selected cases has a significant yield for colorectal cancer. <h3>Disclosure of interest</h3> None Declared.
Reading Disorder
Authors: Janet M. Torpy
Journal: JAMA (2004)

Reading DisorderA s many as 15% of school-aged children have a learning disability.One of those learning disabilities is reading disorder, also known as dyslexia.In this disorder, reading achievement is substantially below what would be expected for the person' s age, intelligence, and educational level.Many areas of the brain are involved in reading.Abnormalities in processing in these brain areas are associated with having dyslexia.It appears that persons who have dyslexia have difficulty processing sound-based components of language.They have difficulty associating symbols (such as letters) with the sounds that these symbols have.Dyslexia does not affect thinking ability.Persons who have dyslexia are often creative in learning to compensate for their disability.Reading difficulties may also arise from poor vision, decreased hearing ability, emotional problems, or behavioral disorders.Behavioral disorders, such as attention-deficit/hyperactivity disorder (ADHD), may also coexist with learning disorders.The April 28, 2004, issue of JAMA includes an article showing that reading difficulties are more common in boys than in girls.
AB1063 Diagnostic Classification of Ileum-Lumbar Ligamentite
Authors: L. Wolenski, E. Bizzi, S. Galletti, R. Galletti, A. Marchi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The involvement of the ileum-lumbar ligamentite (ILL) by degenerative or inflammatory processes is difficult to detect, however it is common and a cause of pain and disability. The differential diagnosis of pain, caused by inflammatory processes borne by the ILL is complex and not always clinical semiotic guarantees a certain diagnosis. <h3>Objectives</h3> The objective of the study is on identifying an echographic approach through the analysis of quantitative parameters, aimed at the eventual confirmation of diagnosis of ileum-lumbar ligamentite solely based on clinical symptoms. <h3>Methods</h3> The ultrasound evaluation of ILL was performed by placing the patient prone and using in the lumbar region, a linear probe for the identification of a precise point of reference for the ILL. The variable sonographic P1, consisting in the iliac insertion of the ligament, was established at 0.5 cm from the iliac crest, along the course of the ligament (Figure 2). At the level of P1 was evaluated the thickness of the ILL in both healthy subjects and in subjects in which clinical semiotic posed diagnosis of inflammatory involvement of the ILL to highlight the possible correlations between the thickness of the ILL and the clinical diagnosis. Thus a binary variable concerning the clinical diagnosis was added to the quantitative variable. The variables were submitted to a statistical analysis through the development of a binary logistic regression model, in which we assumed the diagnosis as the dependent variable and the variable thickness as regressor, with the goal of understanding if the echographic (ligament thickness in P1) and the clinical variables are interrelated. <h3>Results</h3> The analysis sample is made up of 84 patients, of which 43 are healthy subjects. Demographic statistics are shown (Table 1). The analysis of quantitative statistics through distribution graph Box-plot (Figure 1) highlights an important and significant correlation between the clinical diagnosis and parameter P1, where there is an association between lower values of P1 variable and healthy patients and vice versa. In addition, healthy patients have lower dispersion with a median equal to 2.20 mm and half of patients are distributed around the median, with values ranging between 2.10 and 2.50 mm. Conversely ill patients have a median value of P1 of 3.4 mm. From binary logistic regression analysis, we affirm that the estimated model was able to correctly predict 90.5% of cases, in particular 93% of healthy subjects and 87.8% of pathological subjects (Table 2). <h3>Conclusions</h3> This preliminary study could enhance the role of ultrasonography in the diagnosis of ileum lumbar ligamentite. <h3>Disclosure of Interest</h3> None declared
Family interactions as etiological factors in mental disorders: An analysis of the American Journal of Insanity, 1844-1848
Authors: W R McPeak
Journal: American Journal of Psychiatry (1975)

A review of the first four volumes of the American Journal of Insanity indicated that the primary etiological factor noted by authors during that period was disturbed brain functioning, although emotional factors were often mentioned as additional explanations for mental illness. The influence of familial factors and interactions on the development of mental illness was rarely explored. The author concludes that psychiatry at this time did not yet recognize the importance of the dynamics of and interpersonal stresses within family relationships.
Digit-symbol performance in methadone-treated ex-heroin addicts
Authors: P W Appel, N B Gordon
Journal: American Journal of Psychiatry (1976)

The digit-symbol substituion task (DSST) of the WAIS was given to working (MW) and nonworking (MNW) patients on high-dose methadone maintenance and to two comparison groups to assess the function of attention in these patients. Mean DSST scores were significantly lower for the MNW group than for the other three groups, which did not differ. However, the scores for the MNW group were within the normal range. DSST scores and lenght of methadon treatment (range: 11 months to 8 years) were positively correlated, providing no evidence of deterioration with increasing duration of treatment.
AB0320 Matrix Metalloproteinase-3 Levels in Rheumatoid Arthritis and its Relationship with Other Diseases
Authors: T. Tuncer, A. Kaya, A. Gulkesen, G.A. Kal, G. Akgol
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid Arthritis (RA) and ankylosing spondylitis (AS) are chronic inflammatory diseases that often occur in the society and affect the life quality in a negative way. Since they cause serious morbidity and mortality, early diagnosis and treatment are essential in these diseases. The studies about the diagnostic importance of antibodies (anti MCV) appearing against sitrulin vimentin in RA and AS have recently attracted much attention. <h3>Objectives</h3> In this study, anti MCV levels and its relationship with other disease parameters were searched in the diagnosis of RA and AS. <h3>Methods</h3> Three groups including 30 RA, 30 AS and 30 healthy controls were formed. In all the groups, anti MCV levels were measured by ELISA method. In addition, the patients9 ESH, CRP, anti CCP, RF levels were examined. HAQ and NHP scoring were used to measure disability. While, DAS28 was calculated to determine the activation in the patients with RA, in the patients with AS, BASDAI and BASFI were calculated. The relationship of these parameters with anti MCV levels was examined. <h3>Results</h3> While anti MCV levels are determined to be high and statistically significant in Rheumatoid Arthritis and AS group in comparison with healthy control group, any significant difference in anti MCV levels was not determined between RA and AS. Anti MCV levels were positive in 19 patients out of 30 with RA, in 16 patients out of 30 with AS and in 10 patients out of 30 in healthy control group. According to these results, the sensitivity of anti MCV was found to be 63.3% and the specificity of anti MCV was 66.6% in RA, the sensitivity of anti MCV was 53.3% and the specificity of anti MCV was 66.6% in AS. The relationship of anti MCV levels with ESH, CRP, anti CCP, RF levels and activation parameters such as DAS28, BASDAI and BASFI was not determined. <h3>Conclusions</h3> As a result, anti MCV is thought to be used as a diagnostic marker in the diagnosis of Ra and AS. However, large-scale studies about disease activation and use in follow-up after treatment are needed. <h3>Disclosure of Interest</h3> None declared
Clinical outcomes of a scapular-focused treatment in patients with subacromial pain syndrome: a systematic review
Authors: Elja A E Reijneveld, Suzie Noten, Lori A Michener, Ann Cools, Filip Struyf
Journal: British Journal of Sports Medicine (2016)

To systematically review the literature on the clinical outcomes of scapular-focused treatments in participants with subacromial pain syndrome (SPS).Systematic literature review. Studies were appraised by two reviewers using the Physiotherapy Evidence Database (PEDro) scale, and a best-evidence synthesis was performed.The literature search was conducted in the databases PubMed, Embase and Cinahl up to February 2015.Randomised controlled trials evaluating the clinical outcomes of a physiotherapeutic scapular-focused treatment in participants with SPS.Four studies were included describing various scapular-focused interventions, including scapular-focused exercise therapy, scapular mobilisation and scapular taping. All included studies had a PEDro score of 6 or higher, indicating low risk of bias. There was moderate evidence that scapular-focused treatment compared with other physiotherapeutic treatment is effective in improving scapular muscle strength in participants with SPS. Conflicting evidence was found for improvements in pain, function and clinical measures of scapular positioning. No evidence was found for improvements in shoulder range of motion or rotator cuff muscle strength.There is some support for the use of scapular-focused exercise therapy in patients with SPS. Owing to the low number of studies, no firm conclusions can be drawn. Therefore, more randomised controlled trials are needed to determine the clinical outcomes of scapular-focused exercise therapy, scapular mobilisation techniques and scapular taping in patients with SPS.
Image of the Month—Quiz Case
Authors: Eric Marcotte, Cheguevara Afaneh, Alfons Pomp, Daniel Cherqui
Journal: JAMA Surgery (2013)

WOMAN OF CARIBBEAN DEscent presented to an outside hospital with a history of several months of recurrent postprandial right upper quadrant pain associated with nausea and vomiting.Her white blood cell count and liver function test results were within normal limits.She underwent abdominal ultrasonography and a computed tomography scan of the abdomen, which showed cholelithiasis and a questionable cystic dilatation of the common bile duct.She requested a transfer to the Weill Cornell Medical Center.Serologic test results for Echinococcus were negative.A magnetic resonance cholangiopancreatography was ordered to characterize the anatomy.This showed a round lesion centered in the hepatic hilum measuring 1.9 ϫ 1.9 ϫ 2.1 cm with thin internal septations (Figure 1).Although it was in proximity to biliary structures, a direct communication was not visualized.There was no evidence of lymphadenopathy.She was scheduled for a laparoscopic cholecystectomy and resection of the lesion (Figure 2). What Is theDiagnosis? A. Mirizzi syndrome B. Carcinoma of the gallbladder C. Cystadenoma of the cystic duct D.
A note on some recent studies of released mental hospital patients in the community
Authors: L L Bachrach
Journal: American Journal of Psychiatry (1976)

The author conducted a literature search for follow-up studies of patients released from state mental hospitals to the community to assess the impact of released patients and the community on one another. She found that the follow-up studies lacked comparability in several ways and concludes that there is a need for greater comparability in future studies so that their validity as indicators of patients' postrelease functioning may be increased.
P2-102: Prognostic value of pretreatment serum Cyfra 21-1 and CRP in non-small cell lung cancer patients treated by surgery
Authors: Monika Szturmowicz, Piotr Rudzinski, Grazyna Malecka, Beata Broniarek-Samson, Renata Langfort, Iwona Bestry, Tadeusz Orlowski
Journal: Journal of Thoracic Oncology (2007)
Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party
Authors: D. Grimwade, A. Biondi, M.J. Mozziconacci, A. Hagemeijer, R.A. Berger, M. Neat, K. Howe, N. Dastugue, J.H. Jansen, I. Radford-Weiss, F. Lo Coco, M. Lessard, J.M. Hernandez, E. Delabesse, D. Head, V. Liso, D. Sainty, G. Flandrin, E. Solomon, F. Birg, M. Lafage-Pochitaloff
Journal: Blood (2000)
Entering Data
Authors: Adena Cohen-Bearak
Journal: JAMA (2011)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Genetic Factors in Parabiosis&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: E. J. Eichwald, E. C. Lustgraaf, M. Strainer
Journal: JNCI Journal of the National Cancer Institute (1959)

Parabiotic compatibility is primarily dependent on identical alleles at the H-2 locus. “Bilateral” difference at the H-2 locus—each partner having an H-2 allele not carried by the other—results in separation of partners during or after the 2d week of union. Separation is preceded by cessation of dye transmission (Evans Blue and Hypaque) from the 6th day on. Persistence of union beyond the usual time of separation, “false union,” is merely passive and not accompanied by dye transmission. “Unilateral” difference at the H-2 locus, one partner having an H-2 allele not carried by the other, as in many “pure” F1 hybrid unions, usually results in “parabiotic intoxication” of the partner carrying the foreign allele. Death commonly occurs during the latter half of the 2d week or the first half of the 3d week. Dye transmission ceases early during the 2d week. Dissimilarity in sex, at the H-1 or the H-3 locus, does not result in separation or intoxication. In all groups compatible at the H-2 locus Hypaque transmission has been observed for at least 2 months after union. The subject of parabiotic intoxication is discussed.
Convergent validity of measures of PTSD in Vietnam combat veterans
Authors: M E McFall, D E Smith, D K Roszell, D J Tarver, K L Malas
Journal: American Journal of Psychiatry (1990)

The authors evaluated the convergent validity of several widely used psychometric tests of posttraumatic stress disorder (PTSD) symptoms against DSM-III-R criteria for PTSD in 130 Vietnam combat veterans. Significant positive correlations were found between these instruments and the number of DSM-III-R symptoms endorsed, supporting the validity of psychometric instruments as continuous measures of PTSD symptom severity. The various psychometric measures also correlated moderately with one another, suggesting that they assess related but somewhat separate PTSD phenomena. Finally, predicted relationships between stressors and symptoms were supported by significant correlations between degree of traumatic combat exposure and DSM-III-R and psychometric indexes of PTSD.
Prevention of Bacterial Endocarditis
Authors: A E HUSSAR
Journal: Circulation (1965)

Prevention of Bacterial EndocarditisIN individuals with rheumatic or congenital heart disease, bacteria present in the blood may lodge on damaged heart valves or other parts of the endocardium and cause bacterial endocarditis.For this reason, bacteremia; even though transitory, constitutes a potential threat in such patients.It is established that transitory bacteremia may result from tooth extraction, oral surgical procedures, manipulation of periodontal tissues, removal of tonsils and adenoids, bronchoscopy,