tbuckley/cabot-search huggingface dataset:
Psychiatric problems in third-year medical students
Authors: M H Sacks, W A Frosch, M Kesselman, L Parker
Journal: American Journal of Psychiatry (1980)

Each year as many as one of four medical students experience sufficient emotional pain to seek psychiatric consultation. In many cases the precipitating stress relates to specific stresses associated with the phase of training. In the third year increased clinical responsibility may evoke feelings centered on caretaking, sexuality, and aggression that cannot be contained by an as yet fragile emerging professional identification. The authors present four case histories of third-year medical students to illustrate the complex interaction between family background, motivations to enter medicine, and the specific patient experience that resulted in sufficient distress to require psychiatric consultation.
PTH-199 Home parenteral nutrition: safe and effective documentation
Authors: I Beeby, J Elston
Journal: Gut (2015)

<h3>Introduction</h3> The aim of The Care profile was to develop a robust system of nursing documentation. This was to ensure the provision of safe, evidence based nursing care in the delivery of home parenteral nutrition with improved patient clinical outcomes. <h3>Method</h3> Standards in Nutritional Care have been widely documented as unsafe and calls for improved care highlighted in many recent reports. BAPEN specifically supports the implementation of Care Pathways and includes this as one of the key areas of guidance in the, Malnutrition Matters Toolkit. Improved clinical outcomes and prevention of patient deterioration at home requires robust systems to be in place and used effectively. In response to the High impact intervention Catheter Care Bundle and Epic guidelines we commissioned the development of a new consistent, transparent, equitable document. We developed a working party. We carried out a review of current documentation. Questionnaires about current documentation were circulated across the national nursing team. These were reviewed; the results guided our change process. A literature search was undertaken; this included reviewing current local and national guidelines in Central Venous Access Devices and Parenteral Nutrition. We reviewed care pathways across a variety of health care settings. Version 1 of the Intravenous Care Profile was created. In consultation with our engaged Stakeholders we selected a pilot group and trialled the document. Clinical and documentation audits were developed and used following a three month trial. Audit helped to provide a way of improving and measuring the implementation of key elements of care. Audit 1 results guided adaptation of version 1, Audit 2 results reflected the improvements made; the clinical audit achieved 100% the documentation audit score close at 98%. A national rollout followed. Audit has allowed a cycle of continuous development and improvements to the document. An awareness of local and national influences has helped us understand how to use clinical governance systems including audit to make improvement happen in our area. Using the care profile in our routine daily clinical practice, the risk to patients was minimised. A programme of training was implemented across the company to ensure effective use of the care profile was achieved. <h3>Results</h3> The document is intended to provide a structured approach to improve clinical outcomes. It aims to support local and national guidelines that support improvement in standards of care. In collaboration with our stakeholders we have seen a marked change when reviewing anecdotal evidence of reduction of patient hospital readmission for Parenteral Nutrition related issues. In 2015 we will develop our audit systems and review patient data to investigate the perceived improvement in clinical outcomes and reduction in hospital bed days. <h3>Conclusion</h3> See results. <h3>Disclosure of interest</h3> None Declared.
PTU-176 Systematic review with meta-analysis: prevalence of bile acid malabsorption in irritable bowel syndrome with diarrhoea
Authors: S Slattery, AC Ford, Q Aziz, AD Farmer
Journal: Gut (2015)

<h3>Introduction</h3> Irritable bowel syndrome is a prevalent disorder with a marked socioeconomic burden. Previous studies support the proposal that a subset of patients with features compatible with diarrhoea predominant IBS (IBS-D) have bile acid malabsorption (BAM). We aimed to perform a systematic review and meta-analysis to assess the prevalence of BAM in patients meeting accepted criteria for IBS-D. <h3>Method</h3> MEDLINE and EMBASE were searched up to February 2015. Studies recruiting adults with IBS-D, defined either by the Manning, Kruis, Rome I, II or III criteria and which used 23-seleno-25-homotaurocholic acid (SeHCAT) testing for the assessment of BAM were included. BAM was defined as 7 day SeHCAT retention of &lt;10%. We calculated the rate of BAM and 95% confidence intervals (CI) using a random effects model. The methodological quality of included studies was evaluated using the Quality Assessment for Diagnostic Accuracy Studies (QUADAS-2). <h3>Results</h3> The search strategy identified 6 relevant studies comprising 908 individuals. The rate of BAM ranged from 16.9% to 35.3%, with an unadjusted rate of 29.3%. The pooled rate according to the random effect model was 28.1% (95% CI 22.6–34%), see Figure 1. There was significant heterogeneity in effect sizes (Q-test X<sup>2</sup>= 17.9, <i>p </i>&lt; 0.004; I<sup>2 </sup>72.1%). The type of diagnostic criteria used or study country did not significantly modify the effect. <h3>Conclusion</h3> These data provide evidence that in excess of one quarter of patients meeting accepted criteria for IBS-D have BAM. This distinction has implications for the interpretation of previous studies as well as contemporaneous clinical practice and future guideline development. <h3>Disclosure of interest</h3> S. Slattery: None Declared, A. Ford: None Declared, Q. Aziz: None Declared, A. Farmer Speaker Bureau of: Almirall.
Sex differences in olfactory function in schizophrenia
Authors: L Kopala, C Clark, T A Hurwitz
Journal: American Journal of Psychiatry (1989)

Olfactory identification and olfactory acuity were measured in 41 schizophrenic patients receiving neuroleptic medication and in 43 normal control subjects. The performance of the male schizophrenic patients was significantly lower than that of the female patients and the male and female normal control subjects. The last three subgroups performed at equivalent levels. These findings are discussed with respect to other reported sex differences in schizophrenia, including frequency of specific neurological signs and structural brain abnormalities, response to neuroleptic medication, and long-term outcome. The findings suggest that the sex of the patient may be a critical variable in understanding the processes of schizophrenia.
All-trans-retinoic acid in acute promyelocytic leukemia: let's get on with finding out how good it is.
Authors: R E Gallagher
Journal: Journal of Clinical Oncology (1993)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1993.11.3.589 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8445438 All-trans-retinoic acid in acute promyelocytic leukemia: let's get on with finding out how good it is. R E GallagherxR E GallagherSearch for articles by this author https://doi.org/10.1200/JCO.1993.11.3.589 PDF "All-trans-retinoic acid in acute promyelocytic leukemia: let's get on with finding out how good it is.." Journal of Clinical Oncology, 11(3), pp. 589–590© 1993 by American Society of Clinical Oncology
PTH-150 Giant hiatus hernias in the laparoscopic era
Authors: R Camprodon, S Dighe, A Wan, M Reddy, G Vasilikostas
Journal: Gut (2015)

<h3>Introduction</h3> Laparoscopic repair of giant hiatal hernias (LRGHH) remains a major technical challenge in the successful management of this complex surgical pathology. The aim is to present herein our experience and highlight technical tips in ensuring a safe and efficient approach that improves outcome. <h3>Method</h3> A retrospective review of patients undergoing elective LRGHH for symptomatic disease was undertaken between January 2011 and September 2014. Size of hiatal defect, herniated contents, surgical variations were recorded and correlated with clinical outcomes. <h3>Results</h3> Sixteen LRGHH surgeries were performed by three consultant surgeons [A=8, B=4 and C=4, respectively]. There were six males and 10 females with a median age of 65 years (range 33–74). There were eleven Type 3 and five Type 4 hernias with hiatal defect ranging from 2.8 to 7 cm. Complete sac excision, meticulous crural dissection and repair and Nissen undoplication were performed in all cases. Collis gastroplasty for shortened oesophagus was fashioned in 4 cases, mesh applied in 1 case and Teflon pledgets in further 3 cases. Eight (50%) patients remained asymptomatic at 6 weeks, five (31%) reported minimal reflux that had settled at 4-month follow up. Complications occurred in 3 patients (18.7%) and included: immediate hernia recurrence with gastric necrosis requiring laparoscopic sleeve gastrectomy, recurrent vomiting that underwent laparoscopic adhesiolysis 18 months post initial procedure and post-operative dysphagia requiring endoscopic dilatation. All 3 patients remained symptom free at 24 months. <h3>Conclusion</h3> This report represents the largest reported series in the UK in the modern laparoscopic era. Extensive oesophageal mobilisation to ensure adequate intra-abdominal length and strong crural repair with minimal tension are key to a successful repair. Minimally invasive surgery for such complex major pathology allows perioperative morbidity to remain low with good early outcomes. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Laparoscopic repair of giant paraesophageal hernia: 100 consecutive cases Luketich JD, Raja S, Fernando HC, Campbell W, Christie NA, Buenaventura PO, Weigel TL, Keenan RJ, Schauer PR. Ann Surg. 2000;232(4):608–18 Results of laparoscopic repair of giant paraesophageal hernias: 200 consecutive patients Pierre AF, Luketich JD, Fernando HC, Christie NA, Buenaventura PO, Litle VR, Schauer PR. Ann Thorac Surg. 2002;<b>74</b>(6):1909–15; discussion 1915–6
Rosa mundi
Authors: M. Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Acquired Immunity to the Graft&lt;xref ref-type="fn" rid="fn1"&gt;1&lt;/xref&gt;
Authors: Eichwald, E. J.
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Acquired Immunity to the Graft Get access E. J. Eichwald E. J. Eichwald Department of Pathology, University of Utah College of Medicine, Salt Lake City, Utah Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 705–721, https://doi.org/10.1093/jnci/14.3.705 Published: 01 December 1953
Treatment of Tuberculosis.
Authors: B Dautzenberg
Journal: JAMA (1913)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitamin D supplements do not prevent falls
Authors: Mark J Bolland, Andrew Grey, Ian R Reid
Journal: BMJ (2016)

In their state of the art review on falls, Vieira and colleagues conclude that the strategy of supplementing calcium and vitamin D reduces the risk of falls, 1 but their conclusion is based on contradictory evidence.They cite two meta-analyses from 2009 and 2010 of seven and nine trials, respectively, which reported that vitamin D reduced falls, but another from 2012 of seven trials that reported no such reduction in falls.
Recent Advances in Endocrinology
Authors: S L SIMPSON
Journal: JAMA (1941)

jANUARY 12, 1935 some rationally connected system of hypotheses, and never wholly on direct observations.It is, naturally, in the latter parts of this book that the lack of a theoretical background, such as the economists have possessed for more than a century, is most severely felt.This criticism should not be taken as denying to the authors a great measure of success in an immensely arduous undertaking.
Damage Induced in Sarcoma 37 with Chemical Agents. VII. Diphenyl-propylamines, Diphenylpropylenediamines, Diphenylalkanes, and Related Compounds
Authors: J LEITER, J L HARTWELL, I KLINE, M J SHEAR
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Damage Induced in Sarcoma 37 with Chemical Agents. VII. Diphenyl-propylamines, Diphenylpropylenediamines, Diphenylalkanes, and Related Compounds Get access J. Leiter, J. Leiter Laboratory of Chemical Pharmacology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar J. L. Hartwell, J. L. Hartwell Laboratory of Chemical Pharmacology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar I. Kline, I. Kline Laboratory of Chemical Pharmacology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar M. J. Shear M. J. Shear Laboratory of Chemical Pharmacology, National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 645–654, https://doi.org/10.1093/jnci/14.3.645 Published: 01 December 1953 Article history Received: 07 August 1953 Published: 01 December 1953
Factoring outcomes in ovarian cancer.
Authors: M A Bookman, R F Ozols
Journal: Journal of Clinical Oncology (1996)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1996.14.2.325 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 8636738 Factoring outcomes in ovarian cancer. M A BookmanxM A BookmanSearch for articles by this author , R F OzolsxR F OzolsSearch for articles by this author https://doi.org/10.1200/JCO.1996.14.2.325 First Page PDF © 1996 by American Society of Clinical Oncology
The Field Epidemiology Training Program (FETP) in Germany
Authors: A Ammon
Journal: Eurosurveillance (2001)

The German Field Epidemiology Training Programme (FETP), which started in January 1996, is part of a national effort to improve research capacity for the epidemiology of infectious diseases in Germany. The aim of the two year programme is to develop a cadre of epidemiologists capable of performing outbreak investigations, epidemiological research, and surveillance at an international standard measured in articles published in international peer-reviewed journals. These epidemiologists will also be instructed to train future epidemiologists and public health personnel. The programme is similar to the Epidemic Intelligence Service (EIS) at the Centers for Disease Control and Prevention (CDC) in the United States and the European Programme for Intervention Epidemiology Training (EPIET). The German Federal Ministry for Education and Research funded the costs of a senior epidemiologist who was seconded from the CDC to help initiate this programme.
AB0741 Non Response to TNF-Inhibitor Therapy in Ankylosing Spondylitis is Associated with Restricted Spinal Mobility
Authors: I. Sari, R.D. Inman, J. Chan, A. Omar, R. Ayearst, N. Haroon
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> TNF-inhibitor biological agents represent a significant advance in the treatment of spondyloarthritis (SpA). Despite their effectiveness some patients require a change in treatment because of lack of efficacy or adverse reactions. In the current literature, there are a limited number of studies addressing the predictors of switching in patients with axial SpA. <h3>Objectives</h3> The aim of this study was to investigate the associated factors of anti-TNF switching in patients with ankylosing spondylitis (AS) and non-radiographic axial SpA (nr-ax-SpA). <h3>Methods</h3> Patients with a diagnosis of AS or nr-ax-SpA, who previously failed at least one anti-TNF treatment for lack of efficacy were included in the study. Other forms of SpA (psoriatic arthritis, reactive arthritis and enteropathic arthritis) were excluded. In addition to disease activity and acute phase measures; HLA-B27 status, history uveitis, history of arthralgia/arthritis, smoking status and family history of AS were collected on all patients in whom baseline data (BASFI, BASDAI, BASMI, ESR and CRP) was available. Notation was made of the modified Stoke AS Spine Score (mSASSS) and radiographic hip involvement for each patient. Correlation analysis and logistic regression were performed to evaluate the factors predictive of switching. <h3>Results</h3> There were 183 AxSpA patients (81.4% AS, 18.6% nr-axSpA) in the study. 53 (38.1%) out of 183 patients had at least one switch due to lack of efficacy. Comparison of switchers with patients who did not change biologics revealed that age, sex, diagnostic category, disease duration, BASFI, BASDAI, ESR, CRP, HLA-B27 status, frequency of hip involvement and family history of SpA were not different between the groups (<i>p</i> &gt;0.05, Table-1). BASMI was significantly higher in the group of switchers (<i>p</i>=0.03; 3.6±2.4 vs. 2.6±2.2). In logistic regression, among the variables included in the model (total mSASSS, hip involvement, HLAB-27 status, baseline values of BASFI, BASDAI, BASMI, CRP and ESR), only baseline BASMI predicted the anti-TNF change (<i>p</i>=0.04, β=1.48 [95% CI=1.01-2.17]). <h3>Conclusions</h3> This is the first study to suggest that limitation in spinal mobility, is associated with lower response to TNFi therapy. In contrast, baseline indicators of disease activity did not predict response to TNFi. There were no differences observed in nr-axSpA in comparison with AS, further emphasizing commonalities between these clinical subsets. <h3>Disclosure of Interest</h3> None declared
SAT0043 Identification and Characterization of Novel Molecular Mechanisms for ACPA-Driven Osteoclastogenesis
Authors: A. Krishnamurthy, V. Joshua, K. Amara, C. Cerqueira, K. Lundberg, L. Klareskog, V. Malmström, H. Wähämaa, A.I. Catrina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Anti citrullinated protein antibodies (ACPA) associate with bone destruction in RA <h3>Objectives</h3> We aimed to characterize the molecular mechanisms responsible for APCAs effect. <h3>Methods</h3> ACPA positive and negative IgGs were isolated from synovial fluid (SF, n=26) and peripheral blood (PB, n=38) samples of RA patients. CD14<sup>+</sup> monocytes from PB of ACPA<sup>+</sup> RA patients and healthy individuals were first cultured in the presence M-CSF to generate MΦ, and then further differentiated to OC in the presence of RANKL and M-CSF. In parallel, cells were grown on osteoassay surfaces and bone resorption area was quantified by computer assisted image analysis. In house generated anti-citrullinated monoclonal antibodies obtained from SF B-cells were also tested. Cytokines were measured by cytometric bead arrays in cultures supernatants. Immunohistochemistry (IHC) was used to stain the OCs with biotinylated ACPA IgG and monoclonal anti-citrullinated proteins antibodies. The effect of PAD inhibition (C.I.amidine), IL-8 and TNF inhibition was tested in the osteoclasts cultures. <h3>Results</h3> Polyclonal SF-derived ACPA IgGs increased RANKL-driven osteoclastogenesis from a median of 238 OC/well, IQR 55.5-378.5 to a median of 333.5, IQR 88.8-489.3. PB derived ACPAs had similar effect and equally potency. These changes were paralleled by an increase of bone resorption areas by ACPA IgGs from a median of 4.9%, IRQ 1.9-8.5 to a median of 6.9%, IQR 2.7-10. No significant increase in either osteoclasts numbers or resorption areas was observed with the control ACPA-negative IgGs. Increased osteoclastogenesis was associated with significantly higher levels of IL-8 levels in cultures supernatants (fold increase of 2.0±0.5), while no changes were observed for either TNF or IL-6. Cell exposure to neutralizing anti-IL8 antibodies completely abolished ACPA-mediated osteoclastogenesis. Monoclonal antibodies against cit-vimentin and cit-enolase, but not cit-fibrinogen, had similar effects with the polyclonal ACPAs, promoting osteoclastogenesis. Fab fragments of these monoclonal antibodies retained similar effects. Binding of both polyclonal and monoclonal ACPAs on OC was confirmed using IHC. <h3>Conclusions</h3> ACPA IgGs directly promote osteoclastogenesis and bone resorption, an effect that is dependent on antibody specificity and mediate through a novel IL-8 mediated mechanisms. IL-8 targeting might represent an alternative therapeutic approach to modulate antibody-mediated bone destruction. <h3>Disclosure of Interest</h3> None declared