tbuckley/cabot-search huggingface dataset:
Sex as a Factor in Skin-Tumor Metastasis&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Poel, William E.
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Sex as a Factor in Skin-Tumor Metastasis Get access William E. Poel William E. Poel Laboratory for Experimental Carcinogenesis, Department of Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 6, December 1957, Pages 1013–1022, https://doi.org/10.1093/jnci/19.6.1013 Published: 01 December 1957 Article history Received: 11 March 1957 Published: 01 December 1957
Comparative Stability of the Agent of Chicken Tumor I in Phosphate and Borate Buffers during Incubation for 3 Hours at 37° C
Authors: W. Ray Bryan, Mary E. Maver, John B. Moloney, Mary Ann Thomas, Marguerite T. Sells
Journal: JNCI Journal of the National Cancer Institute (1949)

Journal Article Comparative Stability of the Agent of Chicken Tumor I in Phosphate and Borate Buffers during Incubation for 3 Hours at 37° C Get access W. Ray Bryan, W. Ray Bryan Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary E. Maver, Mary E. Maver Search for other works by this author on: Oxford Academic PubMed Google Scholar John B. Moloney, John B. Moloney Search for other works by this author on: Oxford Academic PubMed Google Scholar Mary Ann Thomas, Mary Ann Thomas Search for other works by this author on: Oxford Academic PubMed Google Scholar Marguerite T. Sells Marguerite T. Sells National Cancer Institute, National Institutes of Healthy, Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 10, Issue 3, December 1949, Pages 647–656, https://doi.org/10.1093/jnci/10.3.647 Published: 01 December 1949 Article history Received: 12 September 1949 Published: 01 December 1949
Association of HDL Cholesterol with Incident Cardiovascular Events by LDL Cholesterol and Apolipoprotein B100 in Women
Authors: Samia Mora, Julie E. Buring, Paul M Ridker, Yadong Cui
Journal: Annals of Internal Medicine (2011)

Low-density lipoprotein cholesterol (LDL-C) is a well-established risk factor for cardiovascular disease (CVD) and is the primary target of therapy (1). While LDL particles are the predominant circulating atherogenic lipoproteins, other triglyceride-rich lipoproteins such as very-low-density and intermediate-density lipoproteins have been implicated in atherogenesis (2). Apolipoprotein B100 reflects the total number of atherogenic lipoprotein particles that include not only LDL particles but also the triglyceride-rich very-low-density and intermediate-density lipoprotein particles, since all atherogenic particles carry an apolipoprotein B protein in a one-to-one fashion (2). By contrast, high-density-lipoprotein (HDL) particles do not carry apolipoprotein B100, but instead carry apolipoprotein A-1. Hence, apolipoprotein A-1 reflects the potentially anti-atherogenic HDL particles, although not in a one-to-one fashion, since each HDL particle may carry one or more apolipoprotein A-1 molecule.

The inverse association between HDL cholesterol (HDL-C) and CVD is well-established (3–9). However, whether this inverse association of HDL-C with CVD remains across different levels of LDL-C is less well-studied, and the clinical significance of low HDL-C in patients with low LDL-C is presently debated. Among men, the inverse association of HDL-C with CVD was consistent across a range of LDL-C in several studies (4,6,10). Among women, particularly healthy women, there is a dearth of studies examining the association of HDL-C across a range of LDL-C (11).

Similarly, while low concentrations of apolipoprotein A-1, the major protein carried by HDL particles, have been associated inversely with CVD (2), it is unclear whether apolipoprotein A-1 is inversely associated with CVD across a range of LDL-C. It is also unclear whether apolipoprotein A-1 or HDL-C are inversely associated with CVD when concentrations of apolipoprotein B100, i.e. total atherogenic particles (including the triglyceride-rich particles), are low.

Therefore, we examined the associations of HDL-C and apolipoprotein A-1 with incident CVD, including coronary and stroke events, in apparently healthy women across a range of concentrations for LDL-C and apolipoprotein B100. Furthermore, since clinicians encounter women with very high HDL-C concentrations and it is unknown if these women are more protected against CVD, a secondary aim of this study was to determine whether extreme elevation of HDL-C occurring spontaneously in these women provided additional protection.
Effect of hydrogen bond formation/replacement on solubility characteristics, gastric permeation and pharmacokinetics of curcumin by application of powder solution technology
Authors: Vijay Sharma, Kamla Pathak
Journal: Acta Pharmaceutica Sinica B (2016)

The present research aimed to improve the dissolution rate and bioavailability of curcumin using the potential of liquisolid technology. Twelve drug-loaded liquisolid systems (LS-1 to LS-12) were prepared using different vehicles (PEG 200, PEG 400 and Tween 80) and curcumin concentrations in vehicle (40%, 50%, 60% and 70%, w/w). The carrier [microcrystalline cellulose (MCC) PH102] to coat (Aerosil®) ratio was 20 in all formulations. The systems were screened for pre-compression properties before being compressed to liquisolid tablets (LT-1 to LT-12). Post compression tests and in vitro dissolution of LTs were conducted and the results compared with those obtained for a directly compressed tablet (DCT) made of curcumin, MCC PH102 and Aerosil®. LTs exhibited higher cumulative drug release (CDR) than the DCT and the optimum formulation, LT-9 (made using Tween 80), was studied by powder XRD, DSC, SEM and FTIR. Ex-vivo permeation of curcumin from LT-9 through goat gastrointestinal mucosa was significantly (P<0.05) enhanced and its oral bioavailability was increased 18.6-fold in New Zealand rabbits. In vitro cytotoxicity (IC50) of LT-9 towards NCL 87 cancer cells was 40.2 µmol/L substantiating its anticancer efficacy. Accelerated stability studies revealed insignificant effects of temperature and humidity on LT-9. In summary, solubility enhancement of curcumin in LTs produced significant improvements in its permeation and bioavailability.
Mutant Prolactin Receptor and Familial Hyperprolactinemia
Authors: Mark E Molitch
Journal: New England Journal of Medicine (2014)

compare the mutant prolactin receptor with other mutant endocrine receptors (parathyroid hormone and growth hormone) characterized by loss of function (hypocalcemia and short stature, respectively).The authors attempt to explain the reproductive abnormalities in their pedigree as being the result of hyperprolactinemia and excessive signaling by the prolactin receptor.They point out the persistent postpartum galactorrhea of the proband is indicative of excess prolactin signaling.However, they report a loss of function in relation to this mutation in heterologous systems.Hyperprolactinemia in the presence of a loss-of-function mutation would not lead to increased signaling.One possibility is that the reproductive abnormalities are mediated by a second receptor, as is the case in syndromes of resistance to other hormones (thyroid hormone and glucocorticoids).Alternatively, the reproductive abnormalities seen could be due to loss of function.One way to resolve this question would be to determine the patients' clinical response to cabergoline: if oligomenorrhea and infertility were due to excess prolactin signaling, one would expect these conditions to resolve with the normalization of prolactin levels after treatment with a dopamine agonist, and if these condition were due to a loss of function in prolactin-receptor signaling, then dopamine agonist treatment would have no effect, despite the normalization of prolactin levels.
AT-23ENCOURAGING SURVIVAL OF PEDIATRIC CENTRAL NERVOUS SYSTEM (CNS) ATYPICAL TERATOID AND RHABDOID TUMOR (AT/RT) TREATED AS PER CHILDREN'S ONCOLOGY GROUP ACNS0333 STUDY: A SINGLE-INSTITUTION EXPERIENCE
Authors: Chenue Abongwa, Ashley Margol, Anum Ahmed, Nathan Robison, Benita Tamrazi, Alexander Judkins, Girish Dhall
Journal: Neuro-Oncology (2016)
Impact of psychiatric comorbidity on length of hospital stay for medical/surgical patients: a preliminary report
Authors: G Fulop, J J Strain, J Vita, J S Lyons, J S Hammer
Journal: American Journal of Psychiatry (1987)

The impact of psychiatric comorbidity on the length of hospital stay was addressed in a study of all medical/surgical patients discharged in 1984 from the Mount Sinai Hospital in New York City (N = 37,370) and Northwestern Memorial Hospital in Chicago (N = 21,889). At both hospitals the mean +/- SD length of stay of the patients with psychiatric comorbidity was significantly longer than that of the other patients: 19.8 +/- 33.3 versus 9.2 +/- 15.3 days at Mount Sinai Hospital and 13.7 +/- 27.7 versus 8.3 +/- 13.2 days at Northwestern Memorial Hospital. Early identification of patients with psychiatric comorbidity would permit appropriate psychosocial intervention, which might shorten their hospital stays.
Myelin basic protein concentrations in the CSF of children receiving methotrexate.
Authors: C R Pinkerton, J M Chessells, N R Hoyle
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.1.112 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2416887 Myelin basic protein concentrations in the CSF of children receiving methotrexate. C R PinkertonxC R PinkertonSearch for articles by this author , J M ChessellsxJ M ChessellsSearch for articles by this author , N R HoylexN R HoyleSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.1.112 PDF "Myelin basic protein concentrations in the CSF of children receiving methotrexate.." Journal of Clinical Oncology, 4(1), pp. 112–113© 1986 by American Society of Clinical Oncology
Clinical signs associated with an increased risk of interstitial lung disease: a retrospective study of 101 patients with dermatomyositis
Authors: C.C. Ang, C.O. Anyanwu, E. Robinson, J. Okawa, R. Feng, M. Fujimoto, Y. Hamaguchi, V.P. Werth
Journal: British Journal of Dermatology (2016)

Pulmonary complications are common in dermatomyositis (DM) and contribute to significant morbidity and mortality1-3. Patients with dermatomyositis and anti-synthethase4, anti-PM/Scl5 or anti-MDA56 antibodies have specific signs (mechanic's hands in anti-synthethase phenotype; skin and oral ulcers, arthritis and arthralgia, and alopecia in anti-MDA5 phenotype and sclerodermatous changes in anti-PM/Scl phenotype) and an increased risk of interstitial lung disease (ILD).

This article is protected by copyright. All rights reserved.
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair
Authors: Susanne Quintes, Bastian G Brinkmann, Madlen Ebert, Franziska Fröb, Theresa Kungl, Friederike A Arlt, Victor Tarabykin, Danny Huylebroeck, Dies Meijer, Ueli Suter, Michael Wegner, Michael W Sereda, Klaus-Armin Nave
Journal: Nature Neuroscience (2016)
NS-03ROBOT-ASSISTED STEREOTACTIC BIOPSY IN DIPG
Authors: Andrea Carai, Alessandro De Benedictis, Raffaella Messina, Franco Randi, Alessandra Savioli, Angela Mastronuzzi, Carlo Efisio Marras
Journal: Neuro-Oncology (2016)

Recent advancements in molecular characterization of diffuse intrinsic pontine gliomas (DIPG) have favored the reintroduction of stereotactic biopsy to obtain tumor samples.Acceptable morbidity has been documented in experienced Centers performing biopsies in clinical trials.Transcerebellar transpeduncular approach has been proposed as a safer and easier way to perform pontine biopsies with favorable risk profile (5-10% of new neurological deficit).From January 2015 to January 2016 six biopsies were performed using the Rosa robotic arm system using a transfrontal precoronary approach.Whenever feasible target was chosen in high diffusion restriction areas or contrast enhancing areas on MRI imaging and fused with CT scan images to maximize precision.Four to six samples were obtained from each procedure allowing histological characterization and H3K27 mutation identification in all cases.We were able to save freshly frozen samples for biological characterization to guide target therapy in all cases.We observed transient worsening of diplopia in two patients, returning to baseline within 1 month.No bleeding was documented at early CT scan and reaching of planned target was observed in all cases.We confirm an acceptable risk profile of DIPG biopsy in experienced hands.Transfrontal approach has the theoretical advantage to be parallel to white matter long tracts of the pons, however a longer needle track is required.Further advantages are supine position during the procedure and possibility to use robotic systems with submillimetric precision and high stability of biopsy needle.These procedures should better be performed at selected Centers offering clinical trials for DIPG.Overall survival
Male Attendance at Title X Family Planning Clinics — United States, 2003–2014
Authors: Ghenet Besera, Susan Moskosky, Karen Pazol, Christina Fowler, Lee Warner, David M. Johnson, Wanda D. Barfield
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Although both men and women have reproductive health care needs, family planning providers traditionally focus services toward women (1,2). Challenges in providing family planning services to men, including preconception health, infertility, contraceptive, and sexually transmitted disease (STD) care (3,4), include their infrequent use of preventive health services, a perceived lack of need for these services (1,5), and the lack of provider guidance regarding men's reproductive health care needs (4). Since 1970, the National Title X Family Planning Program has provided cost-effective and confidential family planning and related preventive health services with priority for services to low-income women and men. To examine men's use of services at Title X service sites, CDC and the U.S. Department of Health and Human Services' Office of Population Affairs (OPA) analyzed data from the 2003-2014 Family Planning Annual Reports (FPAR), annual data that are required of all Title X-funded agencies. During 2003-2014, 3.8 million males visited Title X service sites in the United States and the percentage of family planning users who were male nearly doubled from 4.5% (221,425 males) in 2003 to 8.8% (362,531 males) in 2014. In 2014, the percentage of family planning users who were male varied widely by state, ranging from ≤1% in Mississippi, Tennessee, and Alabama to 27.2% in the District of Columbia (DC). Title X service sites are increasingly providing services for males. Health care settings might want to adopt the framework employed by Title X clinics to better provide family planning and related preventative services to men (3).
Quantitative Evaluation of Chemotherapeutic Agents Against Advanced Leukemia in Mice
Authors: Abraham Goldin, John M. Venditti, Stewart R. Humphreys, Nathan Mantel
Journal: JNCI Journal of the National Cancer Institute (1958)

An assay system employing advanced systemic leukemia (L1210) in mice has been utilized to compare the antileukemic effectiveness of a series of chemical agents. Comparison was made of the relative effectiveness of the compounds in increasing the survival time of the mice, employing the folic acid analogue amethopterin as a standard. Data on 38 compounds are presented. Twenty-three of these had been previously studied against early leukemia and in other tumor systems in a comprehensive study of screening (4). None of the compounds used was as effective as amethopterin in increasing the survival time of the leukemic mice. Reserpine, 6-mercaptopurine, thioguanine, 8-azaguanine, and 5-fluorouracil were 50 to 60 percent as effective as amethopterin. Aminopterin, 2 thiadiazole derivatives, azaserine, and 3 pyrimidines showed 30 to 50 percent of the activity of amethopterin. The remaining compounds tested showed lesser or no activity. The application of this type of assay procedure as a tool for screening and the quantitative evaluation of the action of potential antineoplastic agents are discussed.
LG-49LOW GRADE GLIOMA (LGG) OF THE SPINAL CORD. SPECIFIC LOCATION NEEDS SPECIFIC TREATMENT
Authors: Marta Perek-Polnik, Iwona Filipek, Monika Drogosiewicz, Ewa Swieszkowska, Wieslawa Grajkowska, Elzbieta Jurkiewicz, Marcin Roszkowski, Bozenna Dembowska-Baginska
Journal: Neuro-Oncology (2016)

LG-49. LOW GRADE GLIOMA (LGG) OF THE SPINAL CORD. SPECIFIC LOCATION NEEDS SPECIFIC TREATMENT Marta Perek-Polnik, Iwona Filipek, Monika Drogosiewicz, Ewa Swieszkowska, Wieslawa Grajkowska, Elzbieta Jurkiewicz, Marcin Roszkowski, and Bozenna Dembowska-Baginska; The Children’s Memorial Health Institute, Warsaw, Poland INTRODUCTION: Spinal cord LGG constitute approximately 3,5% of all LGG locations. No specific therapeutic guidelines are available for this specific LGG site. AIM: Analysis of childhood spinal cord LGG. METHODOLOGY: 28 patients treated between2004-2015wereanalyzed for: sex, age, symptoms, pathology, treatment and outcome. RESULTS: There were 20 boys and 8 girls, aged 10 months-17 years, median 4.5 years. Paresis,scoliosis and pain were the most common symptoms. Pathology revealed Pilocytic astrocytoma in 21, Pilomyxoid astrocytoma in 4, LGG NOS in 3 patients. In 5 patients total or subtotal resections was performed, in 17 partial resection, in 6 biopsy were performed. In 13 pts neurological improvement was observed, in 7 – deterioration, the rest remained stable. 13 patients had no further treatment. 15 received chemotherapy: 7 following surgical treatment, 8 at tumor progression. 12 patients started with LGG protocol, 3 with VLB. In 10 patients stabilization, in 5 minimal tumor regression were observed. All patients are alive with median follow-up 3 years 8 months. 5 yr and 10 yr EFS are 52,1%, 27,7, respectively. 10 patients are walking without paresis, 9 with paresis, 2 have scoliosis, 6 pts use wheelchair, 1 is paralized. CONCLUSIONS: Spinal cord LGG have a good prognosis. Surgery improves neurological outcome, but radical resections are not mandated to achieve that. Some patients with tumor residual may not require further treatment, but at tumor progression chemotherapy is the treatment of choice. Quality of life should be the priority in choosing surgical strategy. Neuro-Oncology 18:iii78–iii96, 2016. doi:10.1093/neuonc/now075.49 #The Author(s) 2016. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Tissue microarray analysis to evaluate the role of heat shock protein 27 as a potential biomarker in pancreatic cancer.
Authors: E. Gallmeier, D. Bader, H. Seeliger, G. Assmann, D. Buchner, E. de Toni, T. Kirchner, C. J. Bruns, B. Goke, C. Schäfer
Journal: Journal of Clinical Oncology (2010)

e21053 Background: Heat shock protein 27 (HSP27) is a stress-inducible protein preventing the accumulation of misfolded proteins and participating in the regulation of apoptosis. The role of HSP27 as a biomarker has been investigated in a variety of tumor entities, but little is known about its significance in pancreatic cancer. Applying tissue microarray (TMA) analysis, we correlated HSP27 protein expression with clinical-pathological parameters in surgical specimen from 86 pancreatic cancer patients. Methods: Immunohistochemistry, TMA, database analysis. Results: We found HSP27 expression in 49% of pancreatic cancer samples. HSP27 was predominantly expressed in the cytoplasm. Additionally, membranous staining was observed in single cases. There was no association between HSP27 expression and gender, age, grading, lymph node status, metastases, resection status or tumor size. However, HSP27 expression was strongly correlated with better post-operative survival. Consistently, Kaplan-Meier analyses confirmed a significant influence of HSP27 expression on survival. Other parameters affecting survival were expectedly lymph node status, metastases, and tumor size. The univariate analyses regarding HSP27 expression were reproducible using multivariate Cox-regression analyses adjusted for age, gender, grading, resection status, lymph node status, metastases, and tumor size. Finally, backward selection, excluding the least significant factor one at a time, further supported HSP27 expression to be an independent survival factor in pancreatic cancer. Conclusions: Applying TMA analyses of 86 patients with pancreatic cancer, we identified HSP27 as an independent prognostic biomarker in this tumor type. Additional clinical implications could arise from future studies clarifying the underlying mechanism for this observation, especially in regard to a potential association between HSP27 expression and response to chemotherapy. No significant financial relationships to disclose.
Miranda comes to the hospital: the right to remain silent in civil commitment
Authors: R D Miller, G J Maier, M Kaye
Journal: American Journal of Psychiatry (1985)

One procedural protection that has not generally made the transition from the criminal justice system to involuntary civil commitment is the Fifth Amendment protection against self-incrimination. The authors present the results of a study of the implementation of the right to remain silent, which demonstrate that warning patients that anything they say may be used against them in the commitment hearing has little impact on their willingness to talk to staff or to cooperate with treatment. The authors discuss the possible reasons for their findings.
Treatment of Trigeminal Neuralgia
Authors: R L Busch
Journal: New England Journal of Medicine (1987)

The etiology of trigeminal neuralgia has yet to be elucidated. Thus it is not surprising that no ideal treatment is currently available. The current treatment of choice is medical; Pharmacologic management should be tried to its fullest extent. Increasing dosages and using combination drug therapies are recommended before considering a surgical approach. If drug therapy does not alleviate the pain, a surgical approach may be indicated, although 100% effectivity is not expected. Until the true etiology of trigeminal neuralgia is established, controversy will remain in the treatment of this complex disorder.