tbuckley/cabot-search huggingface dataset:
AB0157 Fc Gamma Receptor Expression Profile in Pediatric-Onset Systemic Lupus Erythematosus: Table 1
Authors: V. Williams, A. Rawat, A. Gupta, S. Singh
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Polymorphisms in the Fcγ receptor (FcγRI, FcγRIIa, and FcγRIIb and FcγRIIIa genes) have been associated with an increased susceptibility to autoimmune diseases including SLE and up-regulation of these may vary with disease activity and infection. There is a paucity of data on FcγR expression pattern in pediatric subjects with SLE. <h3>Objectives</h3> To assess the expression of CD 64 (FcγRI), CD32b (FcγRIIb) and CD16 (FcγRIII) on B lymphocytes, neutrophils and monocytes in children with pediatric-onset SLE (pSLE) and their correlation with disease activity as estimated by the SLEDAI score. <h3>Methods</h3> A cross - sectional descriptive study was conducted at PGIMER, Chandigarh, India. Children aged between 0 and 15 years fulfilling American College of Rheumatology classification criteria (1997) for SLE were enrolled. The study population was divided into active and inactive group using SLEDAI score. Controls were age and sex matched. Blood samples of cases and controls were assessed for CD 64, CD32b, and CD16 expression on B lymphocytes, neutrophils and monocytes by flow cytometry using standard techniques. Median fluorescence intensity (MFI) and percentage of cells expression were calculated using the FACS DIVA software and Kaluza software. <h3>Results</h3> Thirty one children with SLE (14 in active group) and 13 controls were analyzed. The median values of percentage expression of CD 64 on lymphocyte and monocytes and MFI of CD16 on neutrophils in cases and control are tabulated. Statistically significant difference (p&lt;0.05) in expression of CD64 on lymphocytes, MFI of CD16 on neutrophils was noted in cases as compared to controls, while there was no difference between active and inactive cases. No difference was noted in expression of CD64 on monocytes between cases and controls.CD20 was reduced in cases probably secondary to therapy. <h3>Conclusions</h3> The percentage expression of CD 64 expression in lymphocytes and MFI of CD 16 expression in neutrophils were increased in patients of pSLE but no significant association was obtained with disease activity. There is paucity of data in pSLE and thus further studies are warranted to substantiate our finding. No correlation of CD16 and CD32b expression with disease activity was noted in our cohort, probably due to the small sample size. <h3>Disclosure of Interest</h3> None declared
Quantification of Pathway Cross-talk Reveals Novel Synergistic Drug Combinations for Breast Cancer
Authors: Samira Jaeger, Ana Igea, Rodrigo Arroyo, Victor Alcalde, Begoña Canovas, Modesto Orozco, Angel R. Nebreda, Patrick Aloy
Journal: Cancer Research (2016)

Combinatorial therapeutic approaches are an imperative to improve cancer treatment, because it is critical to impede compensatory signaling mechanisms that can engender drug resistance to individual targeted drugs. Currently approved drug combinations result largely from empirical clinical experience and cover only a small fraction of a vast therapeutic space. Here we present a computational network biology approach, based on pathway cross-talk inhibition, to discover new synergistic drug combinations for breast cancer treatment. In silico analysis identified 390 novel anticancer drug pairs belonging to 10 drug classes that are likely to diminish pathway cross-talk and display synergistic antitumor effects. Ten novel drug combinations were validated experimentally, and seven of these exhibited synergy in human breast cancer cell lines. In particular, we found that one novel combination, pairing the estrogen response modifier raloxifene with the c-Met/VEGFR2 kinase inhibitor cabozantinib, dramatically potentiated the drugs' individual antitumor effects in a mouse model of breast cancer. When compared with high-throughput combinatorial studies without computational prioritization, our approach offers a significant advance capable of uncovering broad-spectrum utility across many cancer types. Cancer Res; 77(2); 459-69. ©2016 AACR.
<scp>CD</scp>48 on blood leukocytes and in serum of asthma patients varies with severity
Authors: R. S. Gangwar, Y. Minai‐Fleminger, M. Seaf, A. Gutgold, A. Shikotra, C. Barber, A. Chauhan, S. Holgate, P. Bradding, P. Howarth, R. Eliashar, N. Berkman, F. Levi‐Schaffer
Journal: Allergy (2016)

CD48 is a membrane receptor (mCD48) on eosinophils and mast cells and exists in a soluble form (sCD48). CD48 has a pivotal role in murine asthma and in the proinflammatory interactions of mast cells with eosinophils via its ligand CD244. Thus, CD48 might be important in human asthma.Therefore, two separate cohorts (IL and UK) comprising mild, moderate, and severe asthma and healthy volunteers were evaluated for blood leukocyte mCD48 expression and sCD48 in serum. Asthmatic bronchial biopsies were immunostained for CD48. sCD48 effect on CD244-dependent eosinophil activation was evaluated.Eosinophil mCD48 expression was significantly elevated in moderate while downregulated in severe asthma. mCD48 expression on B, T, and NK cells and monocytes in severe asthma was significantly increased. sCD48 levels were significantly higher in mild while reduced in severe asthma. sCD48 optimal cutoff values for differentiating asthma from health were identified as >1482 pg/ml (IL) and >1619 pg/ml (UK). In asthmatic bronchial biopsies, mCD48 was expressed predominantly by eosinophils. sCD48 inhibited anti-CD244-induced eosinophil activation.mCD48 and sCD48 are differentially expressed in the peripheral blood of asthma patients of varying severity. sCD48 inhibits CD244-mediated eosinophil activation. These findings suggest that CD48 may play an important role in human asthma.
High-Dose Therapy (HDT) with Hematopoietic Stem Cell Transplantation (HSCT) Is Effective Therapy for Patients with Non-Hodgkin Lymphoma (NHL) and Central Nervous System (CNS) Involvement
Authors: R. Gregory Bociek, Peerapon Wong, Fausto R. Loberiza, Philip Bierman, Julie M. Vose, Nicole Shonka, James O. Armitage
Journal: Blood (2010)
THU0394 MRI Assessment of Axial Involvement in Inflammatory Bowel Disease-Related SPA: Age at Disease Diagnosis, Not Extent and Severity of Axial Disease, Relates To HLA-B27
Authors: G. De Marco, D. McGonagle, G. Lettieri, S.Z. Aydin, M. Merashli, J. Hamlin, H. Marzo-Ortega
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Up to 20% of inflammatory bowel diseases (IBD) cases may have an associated form of Spondyloarthropathy (SpA). Axial disease in SpA may vary from sporadic back pain to advanced spinal fusion, undistinguishable from Ankylosing Spondylitis (AS). Magnetic resonance imaging (MRI) is well established in the assessment of spinal disease in SpA, but axial MRI data in IBD are still sparse. In AS and axial Psoriatic Arthritis (PsA), it has previously been shown that the extent and severity of inflammatory changes of bone marrow oedema (BMO) on MRI is related to HLA-B27. <h3>Objectives</h3> The aims of this study were to describe the prevalence and extent of BMO lesions and their relationship with HLA-B27 status in IBD-related SpA with axial symptoms. <h3>Methods</h3> Consecutive MRI scans [thoracic spine (TS), lumbar spine (LS) and sacroiliac joints (SIJs)], from patients attending the Leeds Combined Rheumatology and Gastroenterology service between 2005–2015, were assessed retrospectively. Scans had been performed as part of clinical assessment for inflammatory back pain. All subjects had histological diagnosis of IBD and fulfilled ASAS classification criteria for SpA, HLA-B27 status and demographics were also collected. MRI scans were scored by consensus by two expert readers, blinded to the clinical characteristics of the patients. We used the semiquantitative (0–3) Leeds MRI Scoring System for BMO lesions representative of inflammation in the spine and SIJs, whereby a lesion graded as moderate (grade 2) is considered clinically significant. Concordant data from the two readers were used to report on definite lesions. <h3>Results</h3> MRI scans from 43 patients were available for analysis; mean age 43.4 yrs (SD 13.2, range 18.1–80.9), 25 were females (58.1%). Mean age at SpA diagnosis was 37.1 yrs (SD 11.9, range 17.1–63). HLA-B27 was positive in 15 subjects (34.9%) and was associated with younger age at SpA diagnosis (p=0.015). The median MRI score and number of BMO lesions were 2 (IQR 0–7 and 0–5, respectively), 13 patients (30.2%) scored zero, 14 subjects (32.6%) showed at least 1 clinically relevant lesion (grade ≥2). Gender, current age or age at MRI scan were not associated with HLA-B27. MRI total (whole axial skeleton) and partial (TS, LS and SIJs single analysis) score, number of BMO lesions and severe lesions (total axial skeleton and TS-LS-SIJs single analysis) were not different according to HLA B27 status. <h3>Conclusions</h3> Although the majority of IBD-related SpA do not carry HLA B27, diagnosis at a younger age was related to HLA-B27 status. Axial BMO lesions in IBD disease showed the whole spectrum of changes noted in AS. Unlike AS and axial PsA, no association was found between the extent and severity of MRI-determined axial disease and HLA-B27. <h3>Disclosure of Interest</h3> None declared
Overall and abdominal obesity with insulin sensitivity and secretion in a Han Chinese population: a Mendelian randomisation study
Authors: Tao Wang, Xiaojing Ma, Danfeng Peng, Rong Zhang, Miao Chen, Feng Jiang, Yuqian Bao, Cheng Hu, Weiping Jia
Journal: The Lancet Diabetes & Endocrinology (2016)
PTH-066 Clinical Trial: Effects of Oral Ferrous Sulphate on Haemoglobin, Hepcidin, Disease Activity, Mood and Quality of Life in Adolescents and Adults with Iron Deficiency Anaemia Due to IBD
Authors: J Goodhand, D Rampton, N Joshi, A-B Karim, Y Koodun, L Macken, F Baraket, J Epstein, J Fell, D Ward, T Iqbal, I Sanderson
Journal: Gut (2016)

<h3>Introduction</h3> Iron deficiency anaemia (IDA) is common in inflammatory bowel disease (IBD), can be hard to treat and has a negative impact on quality of life (QOL). Because of previous concerns about the efficacy and safety of oral iron, particularly in young people with IBD, we undertook a trial to assess whether ferrous sulphate is as effective and well-tolerated in adolescents as in adults with IBD. <h3>Methods</h3> Prospective phase IV, open-label, parallel group, 6 week non-inferiority clinical trial to compare the effects of oral ferrous sulphate 200 mg twice daily on Hb, iron status, serum hepcidin, symptoms, disease activity (Harvey-Bradshaw Index, Simple Colitis Clinical Activity Index, C-reactive protein (CRP), faecal calprotectin (FCP), QOL, mood and fatigue psychometric scores in 43 adolescent (age 13–18 years) and 45 adult (&gt;18 years) IBD patients with IDA who were either oral iron-naïve or previously iron-tolerant. <h3>Results</h3> On intention-to treat analysis, ferrous sulphate produced similar small but statistically significant rises in serum Hb in the adolescent (before treatment 10.3 g/dl [0.2] (mean [SEM]); after 11.7 [0.2]: p &lt; 0.0001) and adult groups (before 10.9 g/dl [0.1]; after 11.9 [0.2]: p &lt; 0.0001). There was no statistically significant difference in Hb respone or % transferrin saturation response between the two groups. 24 patients (12 adolescents, 12 adults) failed to complete the protocol, 11 because of iron intolerance. On a per protocol basis, oral iron did not change FCP: adolescents (n = 22) (before 324 ug/g [51], after 281 [47]: p = 0.55); adults (n = 22) (before 359 ug/g [107], after 301 [80]: p = 0.54); CRP was also unaffected by oral iron. There was no relation between baseline FCP and baseline Hb or hepcidin, or the Hb response to oral iron. However, baseline hepcidin was negatively associated with Hb response to oral iron (r = 0.28, p = 0.02). The change in Hb following administration of ferrous sulphate had no effect on the Short IBDQ, Hospital Anxiety and Depression (HADS-A &amp; D), Perceived Stress Questionnaire, or the multi-dimension fatigue inventory (MFI) scores. <h3>Conclusion</h3> Oral ferrous sulphate is no less effective or well-tolerated in adolescents than in adults with IBD, and does not increase disease activity. Baseline serum hepcidin level is inversely related to the increase in Hb produced by oral iron in patients with IBD: its measurement could indicate which patients would do better with intravenous than oral iron. Change in Hb had no effect on QoL, mood or fatigue scores. <h3>Disclosure of Interest</h3> None Declared
SAT0496 Brucellosis Spondylodiscitis: Retrospective Evaluation of The Clinical, Laboratory and Epidemiological Features of 21 Cases
Authors: K. Baccouche, N. Elamri, S. Belghali, Z. Alaya, H. Zeglaoui, E. Bouajina
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Brucellosis is a common zoonosis which still remains a major health problem in our country. Osteoarticular involvement is the most frequent complication. <h3>Objectives</h3> The aim of this study was to retrospectively evaluate the clinical, radiological aspects, laboratory characteristics, complications and treatment oucomes of brucellar spondylodiscitis (BS) cases who were followed between 1997 and 2015. <h3>Methods</h3> this is a retrospective study of 21 cases of brucella spondylitis collected in our rheumatology department <h3>Results</h3> Among 118 cases of infectious spondylodiscitis diagnosed and treated, 21 (17, 8%) were due to brucellosis. It was 16 men and five women with a mean age of 48.9 years. Among our patients, 38% had a profession exposed and 76, 2% were consumers of unpasteurized milk and dairy product. The delay from onset to diagnosis was 4 months and a half. The clinical presentation was fever in 81% cases, sweating in 81% and spinal pain in 100% cases. Neurological signs were observed in 42, 8% cases. A muscular deficit was objectified in 14, 3% cases. Vésicosphinctériens disorders were observed in 9, 5% cases. A single case of spinal cord compression was noted. The localisation of the infection was thoracic, thoraco-lumbar, lumbar and lombo-sacral respectively in 14, 3%, 9, 5%, 62% and 14, 3%. One vertebrae level was affected in 71, 4%. In view of laboratory findings, increased erytrocyte sedimentation rate was detected in 76, 2%, C-reactive protein positivity in 62%, lymphomonocytosis in 19% and anemia in 28, 5% of them. All of the patients had &gt; or =1/160 titers of brucella agglutination test and negative blood culture. MRI findings are as follows: Predilection for the lumbar spine (62%), moderate paraspinal abnormal soft tissue with abscess formation only in 14,3% cases, and diffuse but exclusively anterior involvement, intact vertebral architecture despite evidence of diffuse vertebral osteomyelitis, and disc space involvement. Additionally, epidural extension was detected in 28, 5% cases, and root compression in 9, 5% cases. Clinical and radiological improvements were observed with a combined antimicrobial therapy of doxycycline and rifampicin during 12 weeks. <h3>Conclusions</h3> In endemic areas and in our country, BS is still a public health problem and should be considered in the differential diagnosis of patients with spondylodiscitis. It is difficult to diagnose because its symptoms and signs are non-specific. Therefore, MRI, blood cultures, tissue biopsy and cultures are recommended in suspected cases. <h3>Disclosure of Interest</h3> None declared
Reduced Cyclophosphamide Combined with Etoposide and Total Body Irradiation as a Conditioning Regimen for Patients with Impaired Cardiac Function Undergoing Allogeneic Stem Cell Transplantation.
Authors: Akihide Yoshimi, Yasuhito Nannya, Kumi Oshima, Mamiko Sakata-Yanagimoto, Tsuyoshi Takahashi, Yoshinobu Kanda, Toru Motokura, Shigeru Chiba, Mineo Kurokawa
Journal: Blood (2007)
Wilm’s Tumour 1 (WT1) Mutations Are Associated with FLT3-ITD Mutation and Poor Prognosis in Normal Karyotype AML.
Authors: Jude Fitzgibbon, Karin Summers, Ioannis Kakkas, Jane Stevens, Matthew Smith, Lan-Lan Smith, Gael Molloy, Finlay McDougal, Dominique Bonnet, Bryan D. Young, T. Andrew Lister
Journal: Blood (2006)
An Inconvenient Truth Regarding Operative Emergencies in General Surgery—Reply
Authors: John W. Scott, Joaquim M. Havens
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
HERG K+ Channel Is Essential for Leukemic Cell Migration Induced by SDF-1.
Authors: Huiyu Li, Yi-Mei Du, Linlin Guo, Tiannan Guo, Shenghua Jie, Wen Du, Xiangjun Chen, Wei Liu, Jiahua Zhang, Linlin Fan, Anruo Zou, Songyu Zhang, Shiang Huang
Journal: Blood (2008)
AB0893 Comparison of Anti-Inflammatory Effects of The Gel Included Diclofenac Sodium and The Mixture of Zingiber Officinale, Hyperricum Perforatum, Eugenia Caryophyllata and Laurus Nobilis Oil in Collagen-Induced Arthritis Model in Rats
Authors: Y. Vural, Y. Ugan, A. Yigit, A. Doğru, M. Deryal, E. Uz, H. Vural, S.E. Tunc
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Phytotherapy is a therapeutic option which aims to prevent and treat diseases with using the herbal preparations prepared by the whole or some parts of plants. <h3>Objectives</h3> We aimed to investigate the anti-inflammatory effect of Herbal cream on experimentally induced arthritis model in rats. <h3>Methods</h3> 60 Wistar-albino rats were divided into 5 groups as Control, Freund9s Complete Adjuvant (FCA), Arthritis, Arthritis + Diclofenac gel, Arthritis + Herbal cream. A single dose of saline 300 μL for Control group, a single dose of FCA + acetic acid 300 μL for FCA group, a single dose of collagen Type II + CFA emulsion for other 3 groups injected to induce arthritis intradermally to 5–6 separate sites around the tail. Treatments (diclofenac gel or herbal cream) were given as b.i.d. after day 14, for five consecutive days. Blood samples were collected from all animals at the end of the experiment by cardiac puncture. IL-1β, IL-6, TNF-α, COX-1, COX-2 and hsCRP levels were measured by an ELISA method. <h3>Results</h3> HsCRP levels was found significantly elevated in the Arthritis group when compared to Control group (p&lt;0,0001). In comparison between Arthritis group and Arthritis + Herbal cream groups, there was no significant differences between them according to the levels of hsCRP.In the model of collagen induced arthritis and FCA groups the levels of IL-6 were significantly higher then Control group (p&lt;0,0001). When we compared the Arthritis group to the Arthritis + Diclofenac group IL-6 level was found significantly lower in the latter (p&lt;0,0001). In comparison between Arthritis group and Arthritis + Herbal cream group, significantly lower concentration of IL-6 was found also in Arthritis + Herbal cream group (p&lt;0,0001). Despite COX-1 and COX-2 levels were both significantly lower in Arthritis + Diclofenac group, only COX-2 levels were found significantly low in Arthritis + Herbal cream group. However, no significant difference was found between each group in IL-1β and TNF-α levels. <h3>Conclusions</h3> In our study, we concluded that topical herbal cream has a weak antiinflammatory efficacy via lovering IL-6 but not hsCRP and this efficacy is formed by COX-2 inhibition. However, designing new studies in the future would be valuable to determine the effective dose and mixture to achieve evident improvement. <h3>Disclosure of Interest</h3> None declared
Active Immune Gene Therapy Using ISF35: Responses Associated with Priming for Death Receptor-Induced Apoptosis and Sensitivity to Fludarabine in Patients with CLL and Del 17p
Authors: William G Wierda, Januario Castro, Robier A Aguillon, Deepa Sampath, Annette Jalayer, Charles Prussak, Michael J Keating, Thomas J Kipps
Journal: Blood (2008)
Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
Authors: Rob J.W. Arts, Boris Novakovic, Rob ter Horst, Agostinho Carvalho, Siroon Bekkering, Ekta Lachmandas, Fernando Rodrigues, Ricardo Silvestre, Shih-Chin Cheng, Shuang-Yin Wang, Ehsan Habibi, Luís G. Gonçalves, Inês Mesquita, Cristina Cunha, Arjan van Laarhoven, Frank L. van de Veerdonk, David L. Williams, Jos W.M. van der Meer, Colin Logie, Luke A. O'Neill, Charles A. Dinarello, Niels P. Riksen, Reinout van Crevel, Clary Clish, Richard A. Notebaart, Leo A.B. Joosten, Hendrik G. Stunnenberg, Ramnik J. Xavier, Mihai G. Netea
Journal: Cell Metabolism (2016)
Mobilizing Chemotherapy Followed by G-CSF, Additioned by Plerixafor on Demand, Is Safe and Allows Both Adequate PBSC (Peripheral Blood Stem Cell) Collection and Safe ASCT (Autologous Stem Cell Transplantation) In Multiple Myeloma and Lymphoma Patients
Authors: Immacolata Attolico, Vincenzo Pavone, Angelo Ostuni, Maurizio Musso, Alessandra Crescimanno, Massimo Martino, Pasquale Iacopino, Giuseppe Milone, Patrizia Tedeschi, Attilio Olivieri
Journal: Blood (2010)
P0790 : The effect of renal impairment on multiple-dose pharmacokinetics of the fixed-dose combination of daclatasvir/asunaprevir/beclabuvir
Authors: R. Adamczyk, K. Sims, M. Hesney, M. Wind-Rotolo, M. Stonier, R. Penn, L. Reynolds, F. LaCreta, M. AbuTarif
Journal: Journal of Hepatology (2015)