tbuckley/cabot-search huggingface dataset:
Early human communication helps in understanding language evolution
Authors: Daniela Lenti Boero
Journal: Behavioral and Brain Sciences (2014)

Abstract Building a theory on extant species, as Ackermann et al. do, is a useful contribution to the field of language evolution. Here, I add another living model that might be of interest: human language ontogeny in the first year of life. A better knowledge of this phase might help in understanding two more topics among the “several building blocks of a comprehensive theory of the evolution of spoken language” indicated in their conclusion by Ackermann et al., that is, the foundation of the co-evolution of linguistic motor skills with the auditory skills underlying speech perception, and the possible phylogenetic interactions of protospeech production with referential capabilities.
Career patterns of female and male graduates of a psychiatric residency program
Authors: J F Kashtan, B Dickey
Journal: American Journal of Psychiatry (1984)

The authors surveyed 122 recent graduates of the Massachusetts Mental Health Center to determine whether previously reported differences in career patterns between the sexes persist in younger psychiatrists. Some of the findings are consistent with previous studies, e.g., women work fewer hours than men, take more time off for child rearing, and are less often Board certified. However, women surveyed were not underpaid compared with men, and men showed a growing awareness of the conflicting demands of career and family. The significance of these findings and their implications are discussed.
Granulocyte colony-stimulating factor-mobilized allogeneic peripheral blood stem cells for rescue graft failure after allogeneic bone marrow transplantation in two patients with acute myeloblastic leukemia in first complete remission [letter]
Authors: L Molina, C Chabannon, F Viret, A Moine, J Leger, F Nicolini, D Hollard, JJ Sotto
Journal: Blood (1995)
Platelet Function
Authors: Aaron J. Marcus
Journal: New England Journal of Medicine (1969)

Primary HemostasisTHE term primary or "spontaneous" hemostasis refers to a complex series of biologic events occurring in immediate response to blood-vessel severance or injury. Although damaged or cut blood vessels are known to contract, this contraction alone is insufficient to arrest hemorrhage.1 , 2 Within seconds, however, platelets are observed to adhere to the area of trauma. More platelets soon begin to arrive from the general circulation and stick to those initially deposited. The lumen of the vessel becomes progressively occluded by a platelet mass known as a hemostatic platelet plug. At first the plug is slightly permeable, and small amounts . . .
Impact of erythropoiesis-stimulating agent (ESA) reimbursement policy change on transfusion frequency for patients with chemotherapy-induced anemia (CIA).
Authors: C. S. Mueller, B. Chastek, L. N. Newcomer, M. Senbetta, R. S. McKenzie, C. T. Piech
Journal: Journal of Clinical Oncology (2010)

e16507 Background: Two ESAs (darbepoetin alfa, epoetin alfa) are FDA-approved for reducing transfusions in patients (pts) with CIA. Clinical trial data have reported adverse safety signals in this population with ESA treatment targeting hemoglobin (Hb) > 12g/dL. In April 2007, UnitedHealthcare implemented a non-coverage policy for non-Medicare pts with Hb > 12g/dL. Previously, no Hb restrictions existed. The impact of this policy change on the proportion of ESA-treated pts with CIA requiring transfusion was evaluated. Methods: Retrospective claims of the i3 Innovus database from 7/1/2005 to 6/30/2008 were analyzed. Subjects were commercial enrollees ≥ 18 years with cancer and chemotherapy treatment, ≥ 2 ESA claims, and ≥ 1 qualifying treatment episode, which was defined as number of days from first to last ESA administration (no ESA claim for 90 days prior to first claim and 90 days after last claim). Subjects with claims for surgical procedures or dialysis were excluded. Proportion of pts transfused was evaluated comparing pts that initiated ESA treatment between 1/2006–9/2006 (prechange) and 7/2007–3/2008 (postchange). Results: 4,371 pts were identified; 2,775 and 1,709 had ≥ 1 ESA treatment episode in the pre-change and post- change periods, respectively. Age, gender, and tumor type were similar across both time periods. ESA treatment duration was longer in the prechange compared to postchange period (64.9 vs. 59.6 days; p < 0.001). In the prechange period, 11.5% of pts had ≥ 1 transfusions compared with 15.4% in postchange (p < 0.001). By subset analysis, the largest proportion of pts requiring transfusion was in those with lung cancer (19.8% pre, 29% post; p = 0.009). Conclusions: A small but significant increase in proportion of pts transfused and a small but significant decrease in ESA treatment duration was observed in the post-policy period. It is unknown if the increased transfusion rate was a result of policy implementation or the concurrent changes in the Centers for Medicare and Medicaid Services' coverage criteria for initiation of ESA therapy. Further study should evaluate the long-term impact of the policy on other clinical outcomes. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Centocor Ortho Biotech, United Healthcare Johnson & Johnson Johnson & Johnson
MEDICINE—THE DECISIVE DECADE
Authors: E. Vincent Askey
Journal: JAMA (1960)

IT is characteristic of inaugural speeches to point to the challenges which lie ahead or to mention the threshold at which we stand. I wish that I could depart from this time-honored tradition. Certainly nothing would give me more pleasure than to tell you that I view the future without misgivings and that I see nothing ahead but clear sailing and fair winds. The truth is that I do not. I believe that the next ten years will comprise medicine's decisive decade. I believe that medicine will encounter line squalls, veering winds, and rough waters. I believe that we do stand at the threshold. Arnold Toynbee, the great British historian, has observed that the course of nations throughout history has been determined by their response to the challenges of their time. I believe the same observation applies to the medical profession. We are challenged to prove, once again, that medicine
Chronic Conditions and Limitations of Activity and Mobility. United States—July 1965—June 1967.
Authors: C S Wilder
Journal: Annals of Internal Medicine (1972)

During July 1965-June 1967 an estimated 94.9 million persons, or 49.5 percent of the civilian, noninstitutional population, had one or more chronic conditions. About 22.0 million persons re-ported that they were limited to some extent in their activities as a result of their chronic diseases or impairments, and 6.3 million experienced limitation of mobility to some degree. Persons with limitation of activity had an average of 3.4 chronic conditions, of which 1.4 conditions were reported as causes of limitation. Persons with limitation of mobility had an average of 4.1 chronic conditions, of which 1.5 were named as causes of limitation. Two condition groups, heart conditions and arthritis and rheumatism, were the primary causes of both activity and mobility limitations during July 1965-June 1967; heart conditions were reported as causing 16.4 percent of the activity limitations and 12.6 percent of the mobility limitations, and arthritis and rheumatism caused 14.8 percent of the activity limitations and 24.4 percent of the mobility limitations. These two condition groups were the leading causes of activity limitation in each of four time periods for which reports on causes of limitation of activity have been published from the information derived from the Health Interview Survey. Two condition groups have shown substantial changes in level as causes of activity limitation. Impairments (except paralysis) of back or spine increased from alow of 6.6 percent of limitations during July 1959-June 1961 to 8.2 percent of limitations during July 1965-June 1967. The second group, hypertension without heart involvement, declined as a leading cause from 6.8 percent in July 1959-June 1961 to 5.4 percent during July 1965-June 1967.
Cytochemistry and Morphology of Neoplastic and Nonneoplastic Human Lymph Node Cells with Special Reference to Hodgkin's Disease&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Ackerman, G. Adolph, Knouff, Ralph A., Hoster, Herman A.
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article Cytochemistry and Morphology of Neoplastic and Nonneoplastic Human Lymph Node Cells with Special Reference to Hodgkin's Disease Get access G. Adolph Ackerman, M. S., G. Adolph Ackerman, M. S. Departments of Anatomy and Medicine, The Ohio State University, Columbus, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar Ralph A. Knouff, Ph. D., Ralph A. Knouff, Ph. D. Departments of Anatomy and Medicine, The Ohio State University, Columbus, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar Herman A. Hoster, M. D. Herman A. Hoster, M. D. Departments of Anatomy and Medicine, The Ohio State University, Columbus, Ohio Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 3, December 1951, Pages 465–489, https://doi.org/10.1093/jnci/12.3.465 Published: 01 December 1951 Article history Received: 02 July 1951 Published: 01 December 1951
The Placenta—Most Available, Least Studied
Authors: R W POHL
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Who gets supervised? An extension of patient selection inequity
Authors: R W Burgoyne, S Santini, F Kline, F R Staples
Journal: American Journal of Psychiatry (1976)

A study of 89 individual psychotherapy patients followed by 17 residents in a teaching clinic demonstrated that those presented for supervision significantly differed from the others in being younger, better educated, and better liked by residents and in having higher incomes and longer term treatment. The authors discuss the implications of these findings in relation to the inequity in service time and teaching emphasis that this selection allows.
Sustained Release of Cx43 Antisense Oligodeoxynucleotides from Coated Collagen Scaffolds Promotes Wound Healing
Authors: Daniel J. Gilmartin, Allyson Soon, Christopher Thrasivoulou, Anthony R. J. Phillips, Suwan N. Jayasinghe, David L. Becker
Journal: Advanced Healthcare Materials (2016)

Antisense oligodeoxynucleotides targeting the mRNA of the gap junction protein Cx43 promote tissue repair in a variety of different wounds. Delivery of the antisense drug has most often been achieved by a thermoreversible hydrogel, Pluronic F-127, which is very effective in the short term but does not allow for sustained delivery over several days. For chronic wounds that take a long time to heal, repeated dosing with the drug may be desirable but is not always compatible with conventional treatments such as the weekly changing of compression bandages on venous leg ulcers. Here the coating of collagen scaffolds with antisense oligonucleotides is investigated and a way to provide protection of the oligodeoxynucleotide drug is found in conjunction with sustained release over a 7 d period. This approach significantly reduces the normal foreign body reaction to the scaffold, which induces an increase of Cx43 protein and an inhibition of healing. As a result of the antisense integration into the scaffold, inflammation is reduced with the rate of wound healing and contracture is significantly improved. This coated scaffold approach may be very useful for treating venous leg ulcers and also for providing a sustained release of any other types of oligonucleotide drugs that are being developed.
A novel method for closure of a persistent gastrostomy feeding site fistula
Authors: Mayur Garg, Ana Wilson, Simon Gabe, Brian Saunders, Siwan Thomas-Gibson
Journal: Endoscopy (2015)

A 22-year-old man with congenital intestinal malrotation and autoimmune enterocolitis, previously requiring enteral nutritional support for many years, presented with persistently leaking gastric contents 24 months after the removal of a gastrostomy. Attempted closure with three endoscopic clips at the internal opening 8 months earlier had been unsuccessful.
Histology of Sex-Specific Graft Rejection&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Eichwald, E. J., Lustgraaf, E. C.
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Histology of Sex-Specific Graft Rejection Get access E. J. Eichwald, E. J. Eichwald Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar E. C. Lustgraaf E. C. Lustgraaf Laboratory for Experimental Medicine, Montana Deaconess Hospital, Great Falls, Montana Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 26, Issue 6, June 1961, Pages 1395–1403, https://doi.org/10.1093/jnci/26.6.1395 Published: 01 June 1961 Article history Received: 12 May 1960 Published: 01 June 1961
Recovery and Characterization of a New Simian Herpesvirus From a Fatally Infected Spider Monkey&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: R. N. Hull, A. C. Dwyer, A. W. Holmes, E. Nowakowski, F. Deinhardt, E. H. Lennette, R. W. Emmons
Journal: JNCI Journal of the National Cancer Institute (1972)

Recovery and Characterization of a New Simian Herpesvirus From a Fatally Infected Spider Monkey Get access R. N. Hull, R. N. Hull Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar A. C. Dwyer, A. C. Dwyer Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar A. W. Holmes, A. W. Holmes Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Nowakowski, E. Nowakowski Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Deinhardt, F. Deinhardt Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar E. H. Lennette, E. H. Lennette Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar R. W. Emmons R. W. Emmons Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46206, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, and Viral and Rickettsial Disease Laboratory, Department of Public Health, Berkeley, California 94704 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 49, Issue 1, July 1972, Pages 225–232, https://doi.org/10.1093/jnci/49.1.225 Published: 01 July 1972
Soundings: Appeal of the week?
Authors: Trisha Greenhalgh
Journal: BMJ (2004)

Ever submitted a paper to the BMJ? Ever had a reply saying your paper lacked originality, methodological rigour, or credibility on the Clapham omnibus? Believe it or not, the BMJ's rejection letters are more comprehensive, fair, and sensitive than the ones from JAMA or the Lancet, and its reasons for trashing your work are more likely to be evidence based—at least if a content analysis of my own collection is anything to go by. I'm told that the British Journal of Phenomenology invites an account of how you felt when you opened the letter, and the Journal of Direct Action provides the editor's home address, car registration number, and route to work.

Look at it from the perspective of the overworked editorial staff. Nine-tenths of what they see is crap. The lads and lasses do a brilliant job of sifting out 98% of the tosh and pulling perhaps 75% of the competent science out of the same haystack. Ninety-four per cent of papers are thus appropriately classified: not bad as a screening test.

Except that these figures (representing the prevalence of tosh and the sensitivity, specificity, and accuracy respectively of the editorial process) mean that the chance that your paper is tosh despite being accepted (that's unity minus the positive predictive value) is 10.8%, and the chance that your paper is great science despite being rejected (unity minus the negative predictive value) is 5.3%. That's two and one papers per week respectively, give or take the confidence intervals. The two pieces of published tosh are immediately available for rapid responses on the BMJ website, from which the most incisive contributions will be printed alongside bleatings from the authors and, not infrequently, an admission from the editor that there was a whoopsie somewhere in the process. But the gem that got bounced will remain censored from the public domain until it appears 15 months later in the Journal of Rejected Papers That Nobody Reads.

So here's my idea. If selected by an independent appeals editor, your rebuffed manuscript would be placed on a corner of the BMJ website, along with the rejection letter, the referees' comments, and your appeal letter, plus a disclaimer saying that this paper has a 94.7% chance of seriously misleading the reader and is not endorsed.

What difference would that make? Let's evaluate the system and find out.
NEUROSIS AND SOCIAL CLASS
Authors: LAWRENCE Z. FREEDMAN, AUGUST B. HOLLINGSHEAD
Journal: American Journal of Psychiatry (1957)

We advance the hypothesis that the diagnosis of neurosis is the resultant of an interaction process involving the patient, the doctor, and the social group. A psychiatric census shows that the prevalence of neurosis is positively correlated with social level and that there are important differences in method of referral of neurotics from the various social classes. [SEE SOURCE PDF FOR TABLE 5] By use of a psychological symptom scale, we describe a class configuration, ranging from subjective, introversive symptoms in the top classes to somatic complaints and behavioral difficulties in the lower classes. A social interaction index reveals that the locus of conflict progressed through increasingly wider areas of social dislocation—ranging from intrapersonal symptoms in Classes I and II to severe social and legal collisions in lower Classes IV and V. Correlation of all psychological symptoms and social interaction shows this consistent increase in social difficulties. The correlation of character disorder and social interaction illustrate these relationships in a striking manner. Several operations now in process add to their significance: (a) Professional orientation of the psychiatrist, whether analytic, analytically oriented, or eclectic, is positively correlated with class; (b) patterns of symptoms are positively correlated with class; (c) symptom pattern and social interaction index are also being correlated. From these findings, and from complementary results of the over-all investigation, we adduce that treated neurosis is a process within a social context which can be best understood by systematic observation not alone of the individual but of his interpersonal gestalt. Certain distinguishing characteristics of the social classes are reflected in the neurosis itself.
Recent Advances in Endocrinology
Authors: R S FINKLER
Journal: JAMA (1934)

Considering its concentrated form, this book gives an excellent presentation of the essentials of endocrinology for the reader who does not want a mass of detail and yet wishes competent scientific treatment of the subject. Recent advances in our knowledge are stressed. The book brings up to date the experimental work pertaining to function of the endocrine glands and also deals with the latest discoveries and methods of treatment of their diseases.
TCT-635 ACUTE AND MID-TERM CLINICAL OUTCOMES OF THE EVEROLIMUS-ELUTING BIORESORBABLE VASCULAR SCAFFOLDS IN AN ALL-COMER COHORT
Authors: Ramez El Khoury, Charbel Naim, Nicolas Noiseux, Andre Kokis, François Gobeil, Samer Mansour
Journal: Journal of the American College of Cardiology (2014)