tbuckley/cabot-search huggingface dataset:
Endoscopic Ultrasound-Guided Fine Needle Aspiration with On-site Determination of Cytological Adequacy by Endoscopists
Authors: JO Kim, HJ Kim, YK Cheon, JH Moon, YD Cho, JS Lee, MS Lee, SY Jin, CS Shim
Journal: Endoscopy (2006)

Background: On-site determination of cytological adequacy increases the diagnostic accuracy of EUS-FNA. However it is impossible in many centers and the EUS operators increase the number of pass. Some endoscopists themselves perform on-site determination of cytological adequacy by using Diff-Quik stain, and assess the adequacy of specimens. Aims: This study was performed to evaluate the usefulness of EUS-FNA with on-site determination of cytological adequacy by endoscopists in the absence of a cytopathologist. Patients & Methods: Used were 61 specimens from 49 FNAs (48 patients) that were quite adequate for cytological evaluation. 1) EUS-FNA was performed using an Olympus linear array echoendoscope, and manually operated needles. 2) The cellularity was estimated before Diff-Quik stain. 3) The specimens were air-dry fixed and stained with Diff-Quik stain by endoscopist and others fixed in ethyl alcohol were stained with H & E. 4) Endoscopists performed on-site determination of cytological adequacy, and ended specimen collection by the result of Diff-Quik stain. 4) The final pathologic diagnosis was made on the basis of H & E, Giemsa, and Diff-Quik staining. Results: 1) The specimen collection rate was 100% (61/49). 2) The average number of needle passes was 3.11 (range, 1 to 8) 3) Sensitivity was 95% (38/40) and specificity 44.44% (4/9); positive predictive value was 88.37% (38/43) and negative 66.67% (4/6); accuracy was 85.71% (42/49). 4) There were no remarkable complications. Conclusions: For accurate diagnosis, on-site determination of cytological adequacy should be performed during EUS-FNA even if no cytopathologist is present. Additionally, if endoscopists bring up a sense of discrimination for Diff-Quik stained specimens, diagnostic accuracy might be enhanced more, and the number of needle passes would be minimized.
FEASIBILITY OF ULNAR ARTERY INTERVENTION (AJMER ULNAR ARTERY INTERVENTION GROUP STUDY: AJULAR): EARLY
Authors: Rajendra Gokhroo, Kamal Kishor, Bhanwar Ranwa, Devendra Bisht, Sajal Gupta, Avinash Anantharaj, Kumari Priti
Journal: Journal of the American College of Cardiology (2015)
Clinical Course and Treatment Outcomes of Metastatic Colon Cancer Patients At a Medical Center for Respiratory Diseases
Authors: T. Hirashima, H. Shigeoka, H. Suzuki, T. Yoshifuji, W. Shinzaki, N. Morishita, T. Yamadori, M. Tamiya, T. Shiroyama, N. Okamoto
Journal: Annals of Oncology (2013)
AUTOMATED FITTING AND QUANTITATIVE ANALYSIS OF BRAIN STUDIES UTILIZING THE CLINICAL SOFTWARE BRASS
Authors: PE Radau, PJ Slomka, Per Julin
Journal: Clinical Nuclear Medicine (1998)

Dept. of Nuclear Medicine, University of Western Ontario and London Health Sciences Centre, London, Canada. Karolinska Institute*, Dept. of Clinical Neuroscience, Huddinge University Hospital, Stockholm, Sweden.
Controversial<i>Journal</i>Editorials
Authors: Jerome P. Kassirer, Marcia Angell
Journal: New England Journal of Medicine (1997)

Over the years we have received numerous queries from readers and reporters about controversial editorials. Many of these inquiries suggest considerable confusion about the purpose of Journal editorials and Sounding Board articles (opinion pieces written by people not on the editorial staff). The confusion centers on two questions: Whose opinions do editorials represent? And why don't we regularly seek “balance” on controversial issues? In this editorial, we address these questions. A quick look at other journals shows why it is so easy to become confused about the first question. Consider, for example, the five largest general medical journals: the New . . .
REMNANT CHOLESTEROL PREDICTS CARDIOVASCULAR EVENT RISK IN PATIENTS WITH TYPE 2 DIABETES INDEPENDENTLY FROM THE BASELINE CORONARY ARTERY DISEASE STATE
Authors: Christoph H. Saely, Daniela Zanolin, Philipp Rein, Alexander Vonbank, Andreas Leiherer, Axel Muendlein, Heinz Drexel
Journal: Journal of the American College of Cardiology (2016)
Abstract 771: Therapy of spontaneous primary breast tumors in neu-N transgenic mice by adoptive transfer of vaccine-primed LN T cells also induces a humoral response
Authors: Li-Xin Wang, Gregory E. Plautz
Journal: Cancer Research (2011)

Abstract To investigate factors which regulate T-cell mediated therapy of primary breast tumors in situ, we utilized neu-N transgenic mice. These neu-tolerant mice develop spontaneous breast tumors, several of which we have established as aggressive transplantable tumors and selected stem-like progenitor cells in vitro. We vaccinated neu-N mice with irradiated neupos breast cancer progenitor cells to prime T cells in draining LNs. We purified a minor subset (5% to 10%) of LN cells with a CD62Llow CD4+ or CD8+ phenotype representing recently activated effector cells. CD4 and CD8 subsets were separately activated in vitro with anti-CD3/IL-2/IL-7 for two stimulation cycles to induce 200-fold numerical expansion. Hosts bearing spontaneous primary breast tumors average 80 mm2 were treated with 35 × 106 of each CD4+ and CD8+ subsets. Even though the neu-tolerant hosts did not receive lymphodepletion prior to T cell transfer, the T cells significantly delayed tumor growth compared with untreated control mice (n=4 per group, p=0.037). This extends our previous work showing effective T cell therapy of inoculated lung metastases to primary in situ neu-N breast tumors. Neu is a transmembrane tumor antigen with shared expression between vaccine cells and spontaneous tumors that could contribute to the anti-tumor response. We also searched for evidence of response against other cross-reactive antigens. Interestingly, treated mice developed a humoral response and post-treatment serum IgG bound to neuneg variant tumor cells as well as neupos cell lines whereas pre-treatment serum was non-reactive. The development of an IgG serologic response following effective T cell-mediated therapy (in the absence of co-transferred B cells) indicates that transferred CD4+ T cells provided cognate helper function and immunoglobulin class switch signals to B cells and reversed tolerance to neu as well as other shared tumor antigens. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 771. doi:10.1158/1538-7445.AM2011-771
Assessment of EUS and EUS-Guided FNA Complications in a Large Cohort of Patients
Authors: J Lariño-Noia, J Iglesias-García, S Seijo-Rios, M Vilariño-Insua, M Sobrino-Faya, JE Dominguez-Muñoz
Journal: Endoscopy (2006)

Background: Endoscopic ultrasound (EUS) and EUS-guided fine needle aspiration (FNA) have emerged as accurate and safe methods for the diagnosis and staging of many different gastrointestinal and non-gastrointestinal diseases. Due to the use of special equipments, with unique optical and mechanical properties, the incidence and types of complications of EUS may differ from those seen in other endoscopic explorations. The performance of EUS-FNA may increase the complication risk. Aim: To evaluate the morbimortality associated to EUS and EUS-guided FNA. Methods: Consecutive patients referred to our EUS Unit between January 2003 and October 2005 were evaluated. EUS was performed either by the lineal scanning Pentax FG-38UX or by radial scanning Pentax EG-3630UR. EUS-guided FNA was performed by using 19G and 22G needles (Sonotip II, Mediglobe®). EUS explorations were performed by three echoendoscopists. All procedures were performed under conscious sedation with midazolam and meperidine. Vital signs were continuously monitored. A descriptive analysis of major complications of EUS and EUS-FNA was made. Major complications were defined as the development of perforation, bleeding, sepsis, pancreatitis, peritonitis or respiratory insufficiency related to the procedure and leading to prolonged length of hospital staying. Results: A total of 1073 EUS patients (630 male, 443 female, mean age 56 years, range 17–87 years) were explored over the study period. The radial and linear echoendoscopes were used in 332 (30.9%) and 723 (67.4%) cases, respectively. Both equipments were used in 18 patients (1.7%). EUS-guided FNA was performed in 159 cases (15%). In total, only 4 major complications were described (0.37%). Acute respiratory insufficiency requiring oxygen therapy was developed after diagnostic radial EUS (0.09%) in a patient with chronic obstructive pulmonary disease. Three complications (1.89% of the FNA performed) were clearly related to EUS-guided FNA: A pneumothorax was developed in a patient after puncture of a mediastinal mass, and a gastric bleeding requiring endoscopic haemostasia and a mild acute pancreatitis were developed after FNA of pancreatic masses. No procedure-related death was recorded. Conclusion: EUS and EUS-guided FNA are safe and minimally invasive procedures, with a very low complication rate and no mortality.
Complete esophageal occlusion after band ligation
Authors: S. de Melo
Journal: Endoscopy (2011)

Esophageal variceal ligation (EVL) is commonly used to treat esophageal varices given its safety profile [1]. We report an unusual complication of EVL, complete esophageal obstruction, managed with the use of a clear cap attached to the gastroscope using a “can opener” maneuver.
Chernobyl Has No Early Effect on Childhood Leukemia
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Chernobyl Has No Early Effect on Childhood Leukemia Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 21, 4 November 1992, Page 1616, https://doi.org/10.1093/jnci/84.21.1616 Published: 04 November 1992
PRESENTACIÓN DE UN NUEVO SISTEMA (VideoBox) PARA VISUALIZACIÓN SIMULTÁNEA Y ALMACENAMIENTO DE IMÁGENES ENDOSCÓPICAS Y RADIOLÓGICAS
Authors: F Di Giorgio, J Dolz Abadía, C Vilella Martorell, A Noguera Aguilar, J Francisco, A Brotons
Journal: Endoscopy (2010)

Introducción: La configuración inadecuada de las salas de endoscopia-radiología (CPRE), nos obliga utilizar dispositivos complejos y costosos para integrar, en dos monitores, una imagen simultánea que nos permita realizar el procedimiento con comodidad y seguridad.
An unusual complication of percutaneous endoscopic gastrostomy (PEG) placement in the presence of a large pharyngeal pouch
Authors: J. Patel, A. Jenkins
Journal: Endoscopy (2013)

An 80-year-old man with a known benign lower esophageal stricture and pharyngeal pouch was admitted with a 2-week history of malaise, dysphagia, regurgitation, and weight loss. He had elected not to have the esophageal stricture dilated 3 years earlier. On this admission, the dysphagia persisted despite dilatation of the esophageal stricture, and a contrast swallow study demonstrated most of the contrast entering the pouch, with little entering the esophagus ([Fig. 1 a]); there was some aspiration of contrast ([Fig. 1 b]). The patient was nutritionally too frail for repair of the pharyngeal pouch [1] [2]. Nasogastric tube insertion failed and a decision was taken to insert a percutaneous endoscopic gastrostomy (PEG) via the "pull technique" [3].
Case 23-2006
Authors: Othon Iliopoulos, Gayun Chan-Smutko, R. Gilberto Gonzalez, David N. Louis, James R. Stone
Journal: New England Journal of Medicine (2006)

A 36-year-old man had numbness of the hand after an automobile accident and was found to have hypertension. Evaluation disclosed elevated catecholamine levels and a mass in the right adrenal gland. When the patient was 12 years old, a pheochromocytoma had been removed from the left adrenal gland. A diagnostic procedure was performed.
Impact of SNPs in ERα corepressor SMRT on breast cancer risk and response to endocrine therapy.
Authors: RJ Hartmaier, TC Skaar, J Rae, J Wang, L Li, S Oesterreich
Journal: Cancer Research (2009)

Abstract Abstract #1043 Approximately 1/3 of hormone dependent breast cancers do not respond to tamoxifen treatment. The fact that these tumors are intrinsically resistant suggests that underlying genetic factors are responsible for this phenotype. The two major types of genetic variation are single nucleotide polymorphisms (SNPs) and copy number variations (CNVs). SNPs are the most common form of genetic alteration with an estimated 10 million SNPs across the genome and likely influence both disease susceptibility and response to therapy.&amp;#x2028; Traditionally, researchers have attempted to identify SNPs associated with a clinical outcome in a “top-down” approach by conducting linkage and SNP association studies. However, here we report on a “bottom-up” approach whereby SNPs are first tested in vitro for a functional effect. This awards two benefits over a “top-down” approach: 1) identification of functional SNPs and 2) detailed characterization of the SNP so that the clinical association studies can be designed accordingly.&amp;#x2028; Tamoxifen acts by blocking estradiol (E2) from binding to the estrogen receptor (ERα) and by recruiting corepressors, which then actively repress gene transcription. The critical role of corepressors, especially SMRT, in the proper action of tamoxifen makes them likely to be involved in tamoxifen resistance. Thus, we used a “bottom-up” approach to identify SNPs in ERα corepressors which affect the ability of tamoxifen to suppress ERα function.&amp;#x2028; Here we report the detailed in vitro characterization of a number of SNPs in SMRT (NCoR2) with respect to altered ERα function in the presence of tamoxifen. Further, these SNPs are currently being genotyped so that associations can be made in a population of women receiving tamoxifen as either preventative or adjuvant therapy in which extensive surrogate markers for ERα function were collected during the 1-year follow (hot flash rate, hot flash intensity, lipid profiles, and bone mineral density).&amp;#x2028; Through the discovery of common polymorphisms affecting Tamoxifen response, we hope to identify new diagnostic criteria to predict which patients will respond to anti-estrogen therapy and which will be better candidates for another line of therapy, such as aromatase inhibitors. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 1043.
The Use of 68Ga DOTATATE PET/CT for Diagnostic Assessment and Monitoring of 177Lu DOTATATE Therapy in Pituitary Carcinoma
Authors: Fuad Novruzov, Jamil A. Aliyev, Zane Jaunmuktane, Jamshed B. Bomanji, Irfan Kayani
Journal: Clinical Nuclear Medicine (2014)

A 68-year-old man, with a history of pituitary surgery and radiation therapy for pituitary macroadenoma 20 years earlier, presented with a pituitary mass and enlarging lesions within the posterior fossa and spinal canal. Biopsy revealed low-grade pituitary carcinoma. PET/CT scan showed multiple foci of increased Ga DOTATATE activity including pituitary and posterior fossa lesions. After 3 fractions of Lu DOTATATE therapy, the tumor remained stable over 4 years on MRI and Ga DOTATATE scans. This case illustrates the benefit of Ga DOTATATE PET/CT in malignant pituitary disease to assess potential for somatostatin receptor therapy with Lu DOTATATE and monitor treatment.
Lymphangioma as a rare cause of acute recurrent pancreatitis
Authors: Zeljko Cabrijan, Tajana Stoos-Veic, Mirjana Vukelic-Markovic, Mario Tadic
Journal: Endoscopy (2014)

A 26-year-old woman presented with sharp pain in the upper abdomen. Elevated amylase and lipase levels suggested pancreatitis. Emergency computed tomography (CT) of the abdomen showed a cystic lesion with calcifications and lipid-like tissue located between the aorta and vena cava and compressing the pancreatic head and duodenum ([Fig. 1]). Teratoma was suspected. The patient had experienced acute idiopathic pancreatitis 4 years earlier, at which time CT had shown a pancreatic head pseudocyst, so it seemed that the appearance of the lesion had changed.
Case 1-2014
Authors: Melvin S. Blanchard, Javier M. Romero, Mai P. Hoang
Journal: New England Journal of Medicine (2014)

A 32-year-old man was admitted to the hospital because of loss of vision. Ophthalmologic examination revealed painless conjunctival injection in both eyes, with purulent crusting and discharge on the lashes. A procedure and diagnostic tests were performed.
A Review: New Discoveries Allow Oncogenes to Reclaim Limelight
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article A Review: New Discoveries Allow Oncogenes to Reclaim Limelight Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 9, 3 May 1989, Pages 656–658, https://doi.org/10.1093/jnci/81.9.656 Published: 03 May 1989
The Relation of Obesity to Menstrual Disturbances
Authors: Joseph Rogers, George W. Mitchell
Journal: New England Journal of Medicine (1952)

AMONG clinicians dealing with problems of reproductive physiology there is a widespread clinical impression that obesity is related to amenorrhea and perhaps other functional disorders of menstruation. Wharton's standard textbook of gynecology1 lists obesity as commonly associated with amenorrhea. Duncan2 mentions that various disturbances of menstruation, including dysmenorrhea, functional bleeding, amenorrhea and infertility, are frequently associated with obesity and that weight reduction can be effective in alleviating the menstrual disturbance. Other authors3 4 5 6 7 8 indicate the not infrequent relation of obesity and menstrual disturbances, and Given9 mentions attempts at weight reduction in obese women with amenorrhea as a therapeutic measure.A careful . . .
SP0050 The New Eular EU Public Affairs Strategy: Why IT Matters to People with RMDS
Authors: N.J. Betteridge
Journal: Annals of the Rheumatic Diseases (2014)

<h3>The new EULAR EU Public Affairs Strategy</h3> EULAR9s overarching goal is to improve the quality of life of people living with any form of rheumatic and Musculoskeletal Disease (RMD). One of the ways it does this is by influencing policymakers at the EU level, seeking their support for RMDs as a health, social and political priority. For the first time in its history, EULAR has developed and published a Public Affairs strategy. This relates directly to EULAR9s current five year strategy, <i>Vision 2020</i>, and sets out what and how EULAR will be campaigning to win greater support for RMDs over this period. The lecture is designed to explain the thinking behind this strategy; describe the differences we have made so far and wish to make in future; and to set out practical ways that members and external stakeholders can become involved if they so wish. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6275
PWE-095 A 10 Year Review of the Death Rate and Cause of Death Within a District General Cohort of Inflammatory Bowel Disease Patients: Abstract PWE-095 Table
Authors: M W Johnson, K Lithgo, T Prouse, T Price
Journal: Gut (2013)

<h3>Introduction</h3> Whilst there is a growing body of data supporting the increased risk of colo-rectal cancer in patients with inflammatory bowel disease, little has been written about the overall mortality and cause of death seen in patients with this condition. <h3>Objective</h3> To assess the death rate and cause of death in our cohort of IBD patients. <h3>Methods</h3> A database of all known local IBD patients was established after retrospectively reviewing 37,000 colonoscopy and flexible sigmoidoscopy reports performed at the Luton &amp; Dunstable University Hospital between 2001 and 2011. Histological assessment was then used to cross correlate all patients diagnosed with colitis. The hospital coding officer analysed the database and provided details on all deaths within that cohort over the time period and the cause of death as listed by the hospital record system. <h3>Results</h3> In total 2640 patients with IBD were identified and 186 (7%) of these died between 2001 and 2011. The average age of death was 80 years. The cause of death ranged considerably (see chart). <h3>Conclusion</h3> The Office for National Statistics stated that in 2010 the average lifespan in England and Wales, for men and women, was 85 and 89 years, respectively. The life expectancy in Luton is slightly lower than the national average by approximately 2 years (Annual Public Health Report 2012–2013). The average age of death in our IBD cohort appears substantially lower than expected, with just 41 of the 186 (22%) being related to gastrointestinal causes. Infection (sepsis and pneumonia) appeared to be the single most common cause of mortality 60/186 (37.5%), raising questions about an iatrogenic contribution. <h3>Disclosure of Interest</h3> None Declared.
Abstract 2216: Enhanced discrimination of malignant from benign pancreatic disease by measuring the CA 19-9 antigen on specific protein carriers
Authors: Tingting Yue, Kevin Maupin, Katie Partyka, Lin Li, Michelle A. Anderson, Dean Brenner, Diane Simeone, Ziding Feng, Randall E. Brand, Brian B. Haab
Journal: Cancer Research (2011)

Abstract The CA 19-9 assay detects a carbohydrate antigen on multiple protein carriers, some of which may be preferential carriers of the antigen in cancer. We tested the hypothesis that the measurement of the CA 19-9 antigen on individual proteins could improve performance over the standard CA 19-9 assay. We used antibody arrays to measure the levels of the CA 19-9 antigen on multiple proteins in serum or plasma samples from patients with pancreatic adenocarcinoma or pancreatitis. Sample sets from three different institutions were examined, comprising 420 individual samples. The measurement of the CA 19-9 antigen on any individual protein did not improve upon the performance of the standard CA 19-9 assay (79-88% sensitivity at 75% specificity), owing to diversity among patients in their CA 19-9 protein carriers. However, a subset of cancer patients with no elevation in the standard CA 19-9 assay showed elevations of the CA 19-9 antigen specifically on the proteins MUC1, MUC5AC, or MUC16 in all three sample sets. By combining measurements of total CA 19-9 with CA 19-9 on these individual proteins, the sensitivity of cancer detection was raised to 85-100% in the three sample sets, at a specificity of 75%. This finding demonstrates the potential value of measuring glycans on specific proteins for improving biomarker performance. Furthermore, the definition of subgroups of patients based on the protein carriers of the CA 19-9 antigen and other glycans will guide the further development of informative biomarker panels. Diagnostic tests with improved sensitivity for detecting pancreatic cancer could have important applications for improving the treatment and management of patients suffering from this disease. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2216. doi:10.1158/1538-7445.AM2011-2216