tbuckley/cabot-search huggingface dataset:
Abstract POSTER-CTRL-1206: The mutational landscape of fallopian tube carcinoma
Authors: M.I. Harrell, T. Walshb, K.J. Agnew, B. Norquist, M.K. Lee, S. Bernards, K.P. Pennington, E.M. Swisher
Journal: Clinical Cancer Research (2015)

Abstract Fallopian tube (FT) carcinoma is a rare gynecological malignancy, whose incidence is most likely underestimated due to misdiagnoses as ovarian cancer. Recent advances in pathology with more thorough serial sectioning techniques have led to better identification. We undertook to define germline and somatic mutations in 98 FT carcinoma cases enrolled at diagnosis in IRB-approved studies at the University of Washington, excluding cases with carcinoma identified at the time of risk-reducing surgery. We sequenced DNA from blood and neoplastic tissue using BROCA, a targeted capture and massively parallel genomic sequencing approach that detects all classes of mutation in 64 genes. The fraction of all primary ovarian, peritoneal and FT carcinoma defined as a FT primary increased over time in our tissue bank: FT diagnoses accounted for 23% of cases in the past five years compared to 5% in the previous 10 years (p=0.002). Of 98 subjects with FT carcinoma, 32 (33%) had loss of function germline mutations in 9 genes. Mutations in BRCA1 were identified in 18 (19%), making up the largest number of germline mutations, and in BRCA2 in 4 (4%). Germline mutations were also identified in 6 other known breast and/or ovarian cancer susceptibility genes including 2 in BRIP1 (2%), 2 in CHECK2 (2%), and 1 each in BARD1, BLM, MRE11A, and ATM (1%). One mutation was found in the FA gene FANCL. Additionally, we found 1 mosaic mutations in TP53 (1%) and 2 in PPM1D (2%). Together germline and mosaic mutations were identified in 34 (35%) of cases. We sequenced neoplastic DNA with BROCA in 30 FT carcinomas and found 27 somatic mutations in TP53 (90%), 1 in PTEN (3%) and 1 in CHEK2 (3%). The germline mutation rate was higher in FT carcinoma compared to our previous studies in ovarian carcinoma (35% versus 22%), though the identified genes were similar. Recently identified ovarian cancer susceptibility genes such as BRIP1, BARD1, and PPM1D are also associated with hereditary fallopian tube cancer. Known breast cancer genes (i.e. CHEK2, MRE11A, ATM) and other cancer associated genes (BLM, FANCL) require further study to prove their association with FT or ovarian cancer risk. An increased pathological recognition of the FT as a primary site of disease is changing the relative distribution of FT, ovarian, and peritoneal carcinoma in some centers. Citation Format: M.I. Harrell, T. Walshb, K.J. Agnew, B. Norquist, M.K. Lee, S. Bernards, K.P. Pennington, E.M. Swisher. The mutational landscape of fallopian tube carcinoma [abstract]. In: Proceedings of the 10th Biennial Ovarian Cancer Research Symposium; Sep 8-9, 2014; Seattle, WA. Philadelphia (PA): AACR; Clin Cancer Res 2015;21(16 Suppl):Abstract nr POSTER-CTRL-1206.
Abstract 17128: Primary Prevention With Implantable Cardioverter Defibrillator in High-risk Long-QT Syndrome Patients
Authors: Yitschak Biton, Spencer Rosero, Arthur J Moss, Ilan Goldenberg, Scott Mcnitt, Bronislava Polonsky, Wojciech Zareba
Journal: Circulation (2015)

Background: Implantable cardioverter defibrillator (ICD) is currently indicated for the treatment of long QT syndrome (LQTS) patients who survived aborted cardiac arrest. However, data regarding the role of ICD in primary prevention in patients with LQTS is scarce. Methods: The study population comprised 212 LQTS patients (65% genotype positive) from the Rochester LQTS Registry who had ICD implantation for primary prevention. Cox regression model was used to identify clinical variables that were associated with appropriate shock and inappropriate shock. The efficacy of β-blockers was determined using a time-dependent analysis. Results: During a median follow up time of 9.2±4.9 years the cumulative event rates of appropriate shocks and inappropriate shocks were 23% and 34% respectively. In the entire cohort appropriate shock was associated with QTc ≥ 550 msec (HR=3.94; CI 2.08-7.46; p&lt;0.001) and prior syncope on β-blockers (HR=1.92;(CI 1.01-3.65, p=0.047), β-blockers trended to be protective (HR=0.52; CI 0.26-1.07; p=0.075). Importantly, prior syncope was only important if it happened while on β-blockers. Inappropriate shock was significantly associated with age below 15 at implantation (HR=1.94; CI 1.11-3.38; p=0.019). In patients with positive genotype, appropriate shock was associated with QTc ≥ 550 msec (HR=5.37; CI 2.38-12.10; p&lt;0.001), implantation age ≤ 15 years (HR=2.77; CI 1.08-7.11; p=0.034), LQT2 vs. LQT1 (HR=2.47; CI 0.93-6.52; p=0.069), and multiple mutations vs. LQT1 (HR=2.87; CI 0.88-9.42; p=0.081); β-blockers were significantly protective (HR=0.23, CI 0.09-0.59, p=0.002). Conclusions: Among LQTS patients in whom ICD is implanted for primary prevention, QTc duration and history of syncope while on β-blockers therapy are associated increased risk for appropriate shock. β-blocker treatment remains important in this high-risk group. Those with an ICD implanted before age 15 were at a higher risk of receiving an inappropriate shock.
SP0023 How to Measure Physical Activity in People with Rheumatoid Arthritis
Authors: L. Larkin
Journal: Annals of the Rheumatic Diseases (2015)

Physical activity is recognized globally as a key factor in health (1). Measurement of both physical activity and sedentary behavior patterns is complex and can be conducted using subjective or objective methods. Subjective methods of measurement are reported to be less accurate than objective methods (2). Objective, wearable activity monitors are now widely used in research studies and work by using physiological or mechanical responses to bodily movement as signals to estimate variables that reflect physical activity (3). This session will examine the measurement of physical activity behaviour in people with rheumatoid arthritis (RA). The focus will be on objective measures which have been validated in the people with RA to date. Initially the session will provide an introduction to the measurement of physical activity and key aspects of measurement. A review of studies measuring physical activity in RA will then be provided with consideration of the applicability of these studies in a clinical setting. Finally, the session will identify future opportunities for research and will consider how physical activity can be measured in everyday situations. <h3>References</h3> Haskell, WL, Lee, IM, Pate, RR, Powell, KE, Blair, SN, Franklin, BA, Macera, CA, Heath, GW, Thompson, PD, Bauman, A. (2007). Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association. Med Sci Sports Exerc 39:1423–34 Warren, MJ, Ekelund, U, Besson, H, Mezzani, A, Geladas, N, Vanhees, L. (2010). Assessment of physical activity - a review of methodologies with reference to epidemiological research: a report of the exercise physiology section of the European Association of Cardiovascular Prevention and Rehabilitation. European J of Cardiovasc Prev and Rehabil 17(2):127-39 Bassett DR, Rowlands AV, Tost SG. (2012). Calibration and Validation of Wearable Monitors. Med Sci Sports Exerc 44(1 Suppl 1):S32–S38 <h3>Disclosure of Interest</h3> None declared
Psychiatric aspects of clinical neurology
Authors: R B Schiffer
Journal: American Journal of Psychiatry (1983)

The author assessed 241 inpatients and outpatients on a neurology service for emotional disorders, using a systematic interviewing technique. DSM-III diagnoses were established in 101 of these patients (41.9%). The author presents a descriptive assessment of the patients' emotional disorders as well as data concerning the connections between neurologic and emotional illness.
Ecstasy is making a comeback, European drugs report warns
Authors: Rory Watson
Journal: BMJ (2016)

Methylenedioxymethamfetamine (MDMA), most commonly used in the form of “ecstasy” tablets, is returning as a stimulant drug of choice for young people in Europe, stated the European Monitoring Centre for Drugs and Drug Addiction in its annual report presented in Lisbon, Portugal, on 31 May.1

The report estimated that, after a decline from the peak MDMA usage levels in the early to mid-2000s, 2.1 million people aged 15 to 34 used ecstasy in the past year. Increases in use have been recorded in nine countries, with pronounced rises taking place in Bulgaria, Finland, France, England, and Wales.

The drugs agency pointed out that, whereas the …
Medical Education Loans Public and Private
Authors: G L ANNAN
Journal: JAMA (1964)

SINCE MARCH, 1962, the AMA-ERF Medical Education Loan Guarantee Program has secured more than 11,500 commercial bank loans for medical students, interns, and residents who needed additional money during their training periods. In principal amount, nearly $14 million has been loaned. Notwithstanding the fact that<i>all</i>qualified applicants have received loans, the Congress has considered and passed the Health Professions Educational Assistance Act of 1963 (PL 88-129) which, in part, will provide subsidized loans for students of medicine, dentistry, and osteopathy. Many questions are being raised about the operation and probable relationship between the AMA-ERF program and the federal program. For example, some have asked why the interest rates of the banks in the AMA-ERF program can't be substantially lower. Others have wondered if the "free" money of the government (no interest for as long as seven years) will displace or eliminate the AMA-ERF
FRI0477 Isolated Arthritis Revealing an Underlying Anti-Synthetase Syndrome: Results from a Multicentre International Study
Authors: L. Cavagna, M. Govoni, F.J. Lopez Longo, P. Airò, R. Neri, W.A. Sifuentes Giraldo, F. Iannone, L. Nuno, C. Montecucco, R. Caporali, F. Furini, V. Foschi, F. Franceschini, I. Cavazzana, L. Quartuccio, E. Bartoloni Bocci, M. Giannini, C. Sciré, E. Fusaro, S. Parisi, G. Paolazzi, G. Barausse, C. Selmi, J. Bachiller Corral, E. Bravi, G. Bajocchi, R. Pellerito, A. Russo, S. Barsotti, T. Pina Murcia, S. Castaneda, N. Ortego-Centeno, A. Schwarting, C. Specker, L.A. Saketkoo, J. Weinmann-Menke, K. Triantafyllias, M.-A. Gonzalez-Gay
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Articular involvement is reported to occur in up to 85% of patients with antisynthetase syndrome (ASSD) and it may be the only onset feature, although with frequencies and characteristics not still defined <h3>Objectives</h3> To determine in a large international cohort of anti Jo-1 positive ASSD the prevalence of isolated arthritis at disease onset. To describe the clinical, serological and radiological characteristics and evolution of these patients <h3>Methods</h3> We included all anti Jo-1 positive patients referring to participating centres and with an isolated arthritis at disease onset. The pattern of articular involvement, radiological and serological characteristics of patients were analysed. IgM-Rheumatoid factor (RF) was assessed by immunonephelometry; anti-cyclic citrullinated peptide antibodies (ACPA) by commercial second-generation ELISA kits; anti Jo-1 and anti-Ro positivity by commercially available ELISA kits <h3>Results</h3> An isolated arthritis was the first manifestation in 54 (41 females, 13 males) out of the 225 patients included (167 females, 58 males), with a prevalence of 24%. Main characteristics of arthritis and overal results has been completely reported in table 1. <h3>Conclusions</h3> We confirmed that an isolated polyarthritis is the first symptom of anti Jo-1 positive ASSD in up to a quarter of cases. Arthritis is mainly polyarticular and symmetrical, and the positivity for IgM RF or ACPA or both is not a rare finding, as well as the occurrence of marginal X-rays joint erosions. Anti-Ro positivity and RP occurrence may help clinician in the early identification of ASSD, even if the high rate of subsequent appearance of ILD and myositis clearly suggest that the screening for an underlying ASSD should be performed also in patients that may be undoubtedly diagnosed with RA. <h3>References</h3> Cavagna L, et al. Characterization of anti Jo-1 positive antisynthetase syndrome: results from an international multicentre study. Arthritis Rheum 2014;11:S550. Lefèvre G, et al. Seronegative polyarthritis revealing antisynthetase syndrome: a multicentre study of 40 patients. Rheumatology (Oxford). 2014 Oct 27. pii:keu404. [Epub ahead of print] <h3>Disclosure of Interest</h3> None declared
AB0696 Hypereosinophilia and Disease Flare in Eosinophilic Fasciitis
Authors: F. Berianu, W. Ginsburg
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hypereosinophilia was found at the disease onset in up to 85% of patient with eosinophilic fasciitis. <h3>Objectives</h3> To describe our experience in patients with eosinophilic fasciitis (EF) and hypereosinophilia. To identify if hypereosinophilia is found with EF flare. <h3>Methods</h3> We retrospectively reviewed the charts of the patients with biopsy proven EF seen in our clinic. We identified patients with hypereosinophilia at the onset of disease and follow the eosinophils counts over 3 years (January 2012 to December 2014). <h3>Results</h3> 10 patients with biopsy proven EF and hypereosinophilia at the onset were found. Hypereosinophilia value ranged between: 980-4800 cells/mcl (Normal less 350 cells/mcl). The eosinophil count responded quickly to prednisone which was initiated in all 10 patients. Over 3 years of follow up 5 patients had 7 flares. Hypereosinophilia was identified in 3 patients with 4 flares. None of the patients were on Prednisone at the time of flares. <h3>Conclusions</h3> Hypereosinophilia can be associated with disease flare in some of EF patients found with high eosinophils count at the disease onset. <h3>References</h3> Shulman LE. Diffuse fasciitis with eosinophilia: a new syndrome? Trans Assoc Am Physicians. 1975;88:70-86. Lakhanpal S, Ginsburg WW, Michet CJ, Doyle JA, Moore SB. Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases. Semin Arthritis Rheum. May 1988;17(4):221-231. Lebeaux D, Frances C, Barete S, et al. Eosinophilic fasciitis (Shulman disease): new insights into the therapeutic management from a series of 34 patients. Rheumatology (Oxford). Mar 2012;51(3):557-561. <h3>Disclosure of Interest</h3> None declared
Case 33-1975
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Michael N. Margolies, Austin L. Vickery
Journal: New England Journal of Medicine (1975)

Presentation of Case First admission. A 33-year-old woman entered the hospital because of pelvic pain.She was well until 15 months previously, when she completed her second uneventful pregnancy. One month later she began to have pelvic pain that recurred monthly, approximately one week before each menstrual period. A gynecologist prescribed a combination of estrogen and a progestin, without benefit. Two weeks before admission the pain became more severe and was accompanied by fever and chills. She entered another hospital, where pelvic examination disclosed exquisite tenderness; an antibiotic was administered by vein, and she was discharged one week later . . .
Proliferation of Mammalian Cells in Ion-Controlled Environments&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: John L. Worden, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1961)

Tissue-culture and nuclei-enumeration procedures were used to study the effects of the aerial net space charge, ion concentration and polarity, on the proliferation rates of mammalian cells in vitro. Cells were grown in T-60 flasks containing 15 ml of culture medium, gassed with CO2 in air, and incubated at 37.5° C. The aerial environment within the culture flasks was altered by a tritium ion generator within the flask. Cultures grown in an atmosphere in which negative ions predominated showed a significantly greater proliferation rate than their accompanying controls, whereas those grown in a positively ionized atmosphere were retarded in proliferation rate to an even more significant degree. A second-transplant generation, though grown in a nonionized atmosphere, tended to retain these altered rates of proliferation originally induced by air ionization. A relationship to similar contemporary physiological experiments is indicated and a possible mechanism for the characteristic biological effects of air ions is cited.
PTH-040 Laparoscopic-assisted colonoscopic polypectomy is a safe and effective option for difficult polyps: a single tertiary referral centre experience
Authors: M Garg, Z Tsiamoulos, R Rameshshanker, I Beintaris, H Spranger, A Rajendran, O Faiz, A Antoniou, J Warusavitarne, BP Saunders
Journal: Gut (2015)

<h3>Introduction</h3> Colonic polyps deemed difficult to access or resect at endoscopy are often referred for surgical resection. We report our experience using laparoscopic assisted colonoscopic polyp resection at a single tertiary referral centre. <h3>Method</h3> Combined procedures from 2012 to 2014 for patients referred for resection of colonic polypsons deemed not amenable for safe endoscopic resection or where access was difficult, and therefore planned for laparoscopic assistance, were analysed. Clinical data regarding primary lesion, reason for referral for laparoscopic assistance, and outcomes were recorded. <h3>Results</h3> 15 patients have so far been planned for laparo-endoscopic procedures following multidisciplinary meetings, of whom 1 patient proceeded with surgery alone. 14 patients, with median age 73.0 years (range 35.7–85.1 years) were studied. The main reasons for laparoscopic assistance were: large high risk polyps, unfavourable location and the presence of diverticular disease. The median size of the polyps was 5 cm (range 2.3–15 cm). All procedures were performed under general anaesthetic. Completion of colonoscopic resection was performed with surgical presence without laparoscopic assistance in one. Laparoscopic adhesiolysis was performed in 5 patients to facilitate access. Seven patients required surgical resection (laparoscopic right hemicolectomy in 6 and sigmoid resection in 1). A cancer was confirmed histologically in 3 of these patients, with the other four being adenomas with high-grade dysplasia (HGD, 1) or low grade dysplasia (LGD, 3). In the remaining 7 patients, complete polypectomy was achieved, with histopathology showing adenomas with HGD (2), LGD (1), and lipomas in 3 patients with submucosal lesions, and non-diagnostic material in one patient. Median post-operative length of stay was 2 days (range 1 to 5 days) following colonoscopic resection, and uncomplicated except for post-polypectomy syndrome in one patient. Three of these patients have been followed-up to 6 months, with no recurrence of the lesion seen. Amongst patients requiring surgical resection, length of stay was longer (median 6 days [range 3–21 days], p = 0.002, Mann Whitney), with one patient suffering from anastomotic leak and another from an intra-abdominal fluid collection managed conservatively. <h3>Conclusion</h3> Attempted laparoscopic-assisted colonoscopic polypectomy is an effective strategy in a selected patients, enabling safe and complete polypectomy for lesions that are difficult to resect at primary colonoscopy. This approach may help to reduce surgical morbidity and reduce length of hospital stay. <h3>Disclosure of interest</h3> None Declared.
Lithium Maintenance: Factors Affecting Outcome
Authors: James H. Kocsis, Peter E. Stokes
Journal: American Journal of Psychiatry (1979)

The authors reviewed the charts of 61 manic-depressive outpatients maintained on lithium for 6–75 months for relationships between clinical outcome and various demographic, clinical, and pharmacological variables. Good outcome (50% reduction in episode frequency) did not correlate with any demographic or most natural history variables. A history of frequent episodes was correlated with decreased episode frequency but not with a lower percentage of prophylaxis failure during follow-up. A nonsignificant trend toward decreasing episode occurrence with increasing duration of lithium maintenance was present. Depressions occurred considerably more frequently than manic episodes at adequate maintenance plasma lithium levels. More medication noncompliance was found among patients who experienced both manic and depressive relapses.
Severe Seoul hantavirus infection in a pregnant woman, France, October 2012
Authors: G Macé, C Feyeux, N Mollard, C Chantegret, S Audia, J M Rebibou, G Spagnolo, J B Bour, G A Denoyel, P Sagot, J M Reynes
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
Diabetes Mellitus and Obesity
Authors: Wei-ping Jia
Journal: JAMA (1935)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Changes in Keratin Expression during the Development of Benign Prostatic Hyperplasia
Authors: Y. (a) Xue, F. (b) Smedts, R. (a) Umbas, T. W. (a) Aalders, F.M.J. (a) Debruyne, J.J.M.C.H. (a) de la Rosette, J.A. (a) Schalken
Journal: European Urology (1997)
Recombinant human thyroid-stimulating hormone-aided scintigraphy: comparison of imaging at multiple times after I-131 administration.
Authors: SALIL SARKAR, MENES AFRIYIE, CHRISTOPHER PALESTRO
Journal: Clinical Nuclear Medicine (2001)

Purpose Recombinant human thyroid-stimulating hormone (rhTSH) may be used in lieu of thyroid hormone withdrawal for the evaluation of thyroid cancer. Scintigraphy using the existing rhTSH protocol is performed 48 hours after I-131 administration. The authors investigated the feasibility of whole-body imaging at 72 hours and evaluated thyroid tissue uptake at 48 to 144 hours. Methods Thirty-two patients who previously had thyroidectomy for thyroid cancer were examined. Whole-body imaging was performed routinely at 48 and 72 hours after I-131 administration. Thyroid tissue was visualized in 12 patients, and large foci were imaged for as long as 144 hours. Activity ratios for thyroid tissue to background were determined for 10 patients. Results Whole-body images at 48 and 72 hours were comparable, generally with lower background activity at 72 hours, and thyroid tissue was well visualized at all times after 48 hours. Thyroid tissue-to-background activity ratios at 72 to 144 hours were equal to or greater than those at 48 hours in 9 of 10 patients. Conclusions Recombinant human TSH–aided whole-body scintigraphy is possible 72 hours after I-131 administration, adding flexibility and convenience to the existing protocol and permitting confirmation of findings at 48 hours. Tracer uptake in thyroid tissue persists at later times. Therefore, rapid clearance of background activity appears to be the primary cause of the previously reported decrease in radioiodine retention in euthyroid persons receiving rhTSH.