tbuckley/cabot-search huggingface dataset:
Effect of Two Testosterone Derivatives on Urinary Nitrogen and 17-Ketosteroid Output in Human Subjects
Authors: S KATZ, J R BROICH, W METCALF
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The paradoxical underutilization of partial hospitalization
Authors: E B Fink, R Longabaugh, R Stout
Journal: American Journal of Psychiatry (1978)

Partial hospitalization continues to be underutilized even though its clinical effectiveness for a variety of psychiatric patients has been demonstrated. The authors investigated the potential economic advantage of partial hospitalization by comparing matched groups of day hospital patients and inpatients who had comparable symptoms and prognoses on admission. They present one-year follow-up data documenting the comparability of the study groups on clinical outcome measures and the cost advantages favorable the partial hospitalization group. They discuss possible causes of the paradoxical underutilization of the clinically effective and lower-cost partial hospitalization, which include institutional factors, patients' clinical characteristics, family resistance, and clinician bias.
Asthma in Children
Authors: Francis M. Rackemann, Mary C. Edwards
Journal: New England Journal of Medicine (1952)

Negative Skin TestsThe first installment of this paper described the study of 370 children with asthma who were seen before age thirteen and showed positive skin tests. This section deals with a group of 79 cases (48 boys and 31 girls) comparable except that skin tests showed no reaction to any of the common foods or dusts. Of these 79 cases, 49 are "cured"; they include 32 boys and 17 girls who have had no asthma since their teens. Their asthma began at average age 3.6 and they were first seen at average age 6.8; their asthma cleared at . . .
γ-Secretase inhibitor–resistant glioblastoma stem cells require RBPJ to propagate
Authors: Xing Fan
Journal: Journal of Clinical Investigation (2016)

Targeting glioblastoma stem cells with γ-secretase inhibitors (GSIs) disrupts the Notch pathway and has shown some benefit in both pre-clinical models and in patients during phase I/II clinical trials. However, it is largely unknown why some glioblastoma (GBM) does not respond to GSI treatment. In this issue of the JCI, Xie et al. determined that GSI-resistant brain tumor-initiating cells (BTICs) from GBM express a higher level of the gene RBPJ, which encodes a mediator of canonical Notch signaling, compared to non-BTICs. Knockdown of RBPJ in BTICs decreased propagation in vitro and in vivo by inducing apoptosis. Interestingly, RBPJ was shown to regulate a different transcription program than Notch in BTICs by binding CDK9, thereby affecting Pol II-regulated transcript elongation. Targeting CDK9 or c-MYC, an upstream regulator of RBPJ, with small molecules also decreased BTIC propagation, and prolonged survival in mice bearing orthotopic GBM xenografts. This study not only provides a mechanism for GSI treatment resistance, but also identifies two potential therapeutic strategies to target GSI-resistant BTICs.
Effect of Low Protein Diet on Ratio of Essential to Nonessential Amino Acids in Blood Plasma
Authors: M E SWENDSEID, W H GRIFFITH, S G TUTTLE
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
My most unfortunate mistake: Clinical skills
Authors: Femi Idowu
Journal: BMJ (2005)

I had just graduated from medical school in Lagos, probably the most cosmopolitan city in Nigeria, only to find myself for various reasons pursuing my postgraduate training in obstetrics and gynaecology in a place called Ilorin, about 200 miles from home.

About six weeks into my residency, I presented the case of a middle aged woman with lower abdominal mass to the then professor and in front of a packed ward round. The patient's son in law had brought her into hospital; her daughter (his wife) was left at home because she had recently given birth.

I had recently read about ovarian tumours and was pleased to find such a fine case to show off my newly acquired knowledge to my audience, one of whom was my then girlfriend. My clinical presentation and demonstration of the “salient clinical sign” took about 20 minutes, and I could almost feel myself growing in stature—something that really mattered to me as a “Lagos boy.”

After my presentation, the professor asked for comments; of course, there was none from those in attendance. Then, without any fuss, he reached into the pocket of his clinical coat as he approached the patient, obscuring my view. What I heard next brought my recently elevated status crashing down; it was the distinct sound of a fetal heart beat from a pocket Sonicaid detector. If only ultrasound scans were commonplace then as they are now.

What is the take home point from this? Always keep your clinical skills up to date. They are cheap, easily serviceable, and reliable.
Alexithymia
Authors: John G. Flannery
Journal: Psychotherapy and Psychosomatics (1978)

Unexplained physical distress, when associated with alexithymia, becomes a diagnostic puzzle leading to prolonged investigation, ineffective treatment, and psychiatric referral. The persistent, often almost indescribable quality of the distress suggests a central disturbance of the mechanism of pain experience involving the limbic system and the endogenous opiates.
Psychopathology, hypnotizability, and dissociation
Authors: E J Frischholz, L S Lipman, B G Braun, R G Sachs
Journal: American Journal of Psychiatry (1992)

The purpose of the study was to replicate and extend previous findings regarding the hypnotizability of different clinical groups.The authors compared the differential hypnotizability of four psychiatric groups--patients with dissociative disorders (N = 17), schizophrenia (N = 13), mood disorders (N = 13), and anxiety disorders (N = 14)--and one normal group of college students (N = 63). Hypnotizability was assessed by four different measures: the eye roll sign and the induction score of the Hypnotic Induction Profile, the Stanford Hypnotic Susceptibility Scale, Form C, and two self-ratings of hypnotizability.As predicted, dissociative disorder patients had significantly higher hypnotizability scores on all measures than all other groups. Schizophrenic patients, on the other hand, had significantly lower scores than normal subjects on the eye roll sign and induction score but not on the other measures of hypnotizability. Some other unpredicted between-group differences were also found. Nevertheless, despite the between-group differences, the intercorrelations between the various hypnotizability measures within the normal group were very similar to those observed in the combined patient groups.The findings suggest that routine hypnotizability assessment may be useful in the differential diagnosis of patients with dissociative disorders.
Platelet MAO activity in primary degenerative dementia
Authors: G S Alexopoulos, K W Lieberman, R C Young
Journal: American Journal of Psychiatry (1984)

Platelet MAO activity was studied in 24 patients with primary degenerative dementia and 20 normal elderly controls. Demented patients had significantly higher platelet MAO activity than did controls. The increase was greater than that reported to occur in normal aging.
Induced Adaptation in a Tumor: Permanence of the Change
Authors: Morris K. Barrett, Margaret K. Deringer
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article Induced Adaptation in a Tumor: Permanence of the Change Get access Morris K. Barrett, Morris K. Barrett National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Margaret K. Deringer Margaret K. Deringer National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 5, April 1952, Pages 1011–1017, https://doi.org/10.1093/jnci/12.5.1011 Published: 01 April 1952 Article history Received: 05 December 1951 Published: 01 April 1952
Methicillin resistant Staphylococcus aureus (MRSA) as a community strain
Authors: J H T Wagenvoort, M Kepers-Rietrae
Journal: Eurosurveillance (1997)

Methicillin resistant Staphylococcus aureus (MRSA) has become particularly well known in association with hospital acquired infections but is also known to have infected people in the community. We define cases of community acquired MRSA infection as the
Reversal of dexamethasone suppression test nonsuppression in alcohol abusers
Authors: G Newsom, N Murray
Journal: American Journal of Psychiatry (1983)

Of 75 detoxified alcohol-abusing inpatients given the dexamethasone suppression test (DST), 13 demonstrated nonsuppression and returned to normal suppression after 4 more weeks of abstinence. The authors question interpreting nonsuppression in alcohol abusers as indicating major depression without a significant period of abstinence.
Modern Surgery, General and Operative.
Journal: JAMA (1931)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary-Tumor Induction with Alkylated Urethans&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: C. D. Larsen
Journal: JNCI Journal of the National Cancer Institute (1948)

Pulmonary-Tumor Induction with Alkylated Urethans Get access C. D. Larsen C. D. Larsen National Cancer Institute, National Institute of Health, Public Health Service Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 9, Issue 1, August 1948, Pages 35–37, https://doi.org/10.1093/jnci/9.1.35 Published: 01 August 1948 Article history Received: 04 May 1948 Published: 01 August 1948
Physical findings in a psychiatric outpatient clinic
Authors: L N Muecke, D W Krueger
Journal: American Journal of Psychiatry (1981)

To determine the frequency of previously undiagnosed, positive physical findings in a psychiatric outpatient clinic population, the authors examined the case records of 910 consecutively admitted patients who had been given screening physical examinations including urinalyses. They found that 20.4% of the patients had some medical abnormality that was previously undiagnosed, and they encourage psychiatrists to make the physical examination a routine part of their total psychiatric evaluation.
Case 14-1969
Authors: Lot B. Page, Robert E. Scully
Journal: New England Journal of Medicine (1969)

Presentation of CaseA sixty-eight-year-old man was admitted to the hospital because of pain radiating to the flank.On the day of entry he experienced the sudden onset of a twitching sensation in the left pectoral region, followed immediately by pain in the left side of the abdomen and chest with radiation to the left flank and periscapular region. The pain was colicky at times; it did not radiate to the groin or testes. There was no nausea, vomiting, cough or dyspnea, and he had no hematuria or dysuria.He had previously been in good health. There was no history . . .
von Willebrand disease in the RIIIS/J mouse is caused by a defect outside of the von Willebrand factor gene [published erratum appears in Blood 1995 Sep 15;86(6):2461]
Authors: WC Nichols, KA Cooney, KL Mohlke, JD Ballew, A Yang, ME Bruck, M Reddington, EK Novak, RT Swank, D Ginsburg
Journal: Blood (1994)
Government scientists “heavily restricted” in communicating their work, MPs told
Authors: Adrian O’Dowd
Journal: BMJ (2016)

Scientists working in government funded institutes are unable to speak freely about their work, MPs have been told.

Fiona Fox, chief executive of the Science Media Centre, told the House of Commons science and technology select committee’s inquiry into science communication that government funded scientists were reluctant to speak freely.

“There is a huge commitment from this government to public engagement, the government office for science, and the wonderful chief scientist, but I see that in contradiction to the fact that government scientists are heavily restricted,” Fox told MPs.

“These are research active scientists that are employed in government institutes. The reason they are not allowed to speak freely is because it is assumed …
Endoscopic mucosectomy of the normal mucosa facilitates exposure of the submucosal layer at the commencement of colorectal endoscopic submucosal dissection
Authors: Jeremie Jacques, Romain Legros, Paul Carrier, Sophie Geyl, Veronique Loustaud-Ratti, Denis Sautereau, Mathieu Pioche
Journal: Endoscopy (2016)

Endoscopic submucosal dissection (ESD) is the treatment of choice for superficial gastrointestinal neoplasms but is technically very difficult, challenging, and time-consuming. It should only be performed by experts. Good exposure of the submucosal layer is key in terms of procedural efficiency and safety [1]. Many have sought to optimize exposure of the submucosal layer using countertraction [2], creation of a pocket, or by tunneling beneath the lesion [3] [4].
Organ-Preserving Surgery in Patients with Urothelial Tumors of the Upper Urinary Tract
Authors: U. Maier, G. Mertl, K. Pummer, W. Höltl, W. Tomschi, C. Mrstik, J. Flamm, P. Petritsch, H. Pum, M. Riccabona, F. Kaufmann, G. Studler, E. Dittel, G. Donner
Journal: European Urology (1990)
CMS-04CEREBELLAR MUTISM SYNDROME IN POSTERIOR FOSSA TUMORS: A BETTER UNDERSTANDING FOR A BETTER COUNSELING. A RETROSPECTIVE ANALYSIS OF PEDIATRIC PATIENTS IN UZ LEUVEN FROM 1990 TO 2015
Authors: Lien Mertens, Liesbeth De Waele, Bart Depreitere, Jurgen Lemiere, Sandra Jacobs
Journal: Neuro-Oncology (2016)

Cerebellar mutism syndrome (CMS) consists of mutism, emotional lability, hypotonia and ataxia.It is induced by resection of midline posterior fossa tumors.Little is known about the risk factors of this syndrome in children and the neurocognitive outcome.METHODS: The patient database of the University Hospitals Leuven was interrogated for pediatric patients followed between 1990 and 2015 using terms as 'posterior fossa tumor', 'mutism' or 'cerebellar syndrome'.73 patients were included.RESULTS: 75 posterior fossa interventions were counted.Median age at resection was 5.73 (0.30-18.43) years.Postoperative mutism was reported in 26.6%: 'Mutism Group' (MG).In 73.3%, mutism was not reported: 'Non-Mutism Group' (NMG).Average age in the MG was 6.85 years (0.30-14.74), in the NMG 6.09 years (0.48-18.43).The most common tumor type was medulloblastoma (65%) in the MG and pilocytic astrocytoma (44%) in the NMG.A telovelar approach was used in 38%, a transvermian in 18%.Postoperative mutism occurred in 28.5% and 30% respectively.Mean total IQ points between intervention and after 2 years (tested in 11/73) declined with 13.6 points in the MG (97.2 vs 83.6, VIQ 97.6 vs 92.2 and PIQ 95 vs 78.2).Mean IQ in NMG remained stable (TIQ 101.8 vs 105.5, VIQ 103.2 vs 109.8,PIQ 102.5 vs 102.5).In the MG 4/5 patients received adjuvant therapy (chemotherapy and/or radiotherapy), in the NMG 3/6 patients.CONCLUSION: CMS is a frequent postoperative syndrome occurring in 26.6% of the studied interventions.Our data indicate that children with CMS have a more impaired neuropsychological outcome.Overall survival
Relationship testing after the loss of a parent
Authors: N B Kaltreider, T Becker, M J Horowitz
Journal: American Journal of Psychiatry (1984)

In this study of adults presenting with symptoms of pathological grief after the death of a parent, there was a frequent pattern of strain on a current love relationship. The attempt to master negative views of the self, precipitated by loss of the parent, through reenactment with the significant other was prominent. Psychotherapy offered an opportunity to rework the feared representation of the self.
Playing Doctor
Authors: Stephen G Henry
Journal: JAMA (2005)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Images in psychiatry. The Massachusetts Mental Health Center
Authors: M T Tsuang
Journal: American Journal of Psychiatry (1997)

after 9 years of relentless effort by L. Vernon Briggs, a psychiatrist in the Mental Department of the Boston Dispensary.Briggs campaigned for an acute treatment center that would be closely tied to Harvard Medical School so that patient care could benefit from research and teaching.Eventually, he convinced the state legislature to appropriate funds to purchase land on Fenwood Road
MB-64ADOPTIVE CELL IMMUNOTHERAPY IN MEDULLOBLASTOMA BASED ON T CELLS REDIRECTED TOWARD TUMOR CELLS BY PRAME SPECIFIC αβTCR GENE MODIFICATION
Authors: Ignazio Caruana, Domenico Orlando, Biagio De Angelis, Iolanda Boffa, Marika Guercio, Andrea Carai, Luca Massimi, Elisabetta Ferretti, Evelina Miele, Agnese Po, Annemarie Moseley, R.S. Hagedoorn, R. de Boer, J.H.Frederik Falkenburg, Mirjam H.M. Heemskerk, Franco Locatelli, Angela Mastronuzzi, amd Concetta Quintarelli
Journal: Neuro-Oncology (2016)
HG-79CASE OF AN UNUSUAL HIGH GRADE GLIOMA IN A 15 Y/O MALE WITH FEATURES OF EPITHELIOID GLIOBLASTOMA ARISING IN ASSOCIATION WITH PLEOMORPHIC XANTHOASTROCYTOMA (PXA)
Authors: David Gass, Chad Jacobsen, Anthony Asher, James Dollar
Journal: Neuro-Oncology (2016)

We present a case of a 15 y/o male who presented with symptoms of
Education is a greater help to women than egg freezing, say experts
Authors: Bryan Christie
Journal: BMJ (2016)

Too many women are “sleep walking” into infertility because they are poorly informed about their declining ability to conceive as they age, said experts at a debate on egg freezing held at the Royal College of Physicians of Edinburgh.

The panel of international experts agreed that better education was needed in schools to inform teenagers that fertility starts to decline from about the age of 30. Most current information aimed at this age group focuses on contraception and sexual health.

Education was proposed as a more helpful intervention than aggressive marketing of egg freezing services by fertility clinics, presenting …
Polio
Authors: Sharon Parmet
Journal: JAMA (2004)

PolioP oliomyelitis (polio) is a highly infectious viral disease that can involve the nervous system and can cause paralysis.Polio is most common in infants and children but can occur in adults.Because of widespread polio vaccination, the disease is now very rare in developed countries but still occurs in developing countries where vaccination coverage is not complete.The October 13, 2004, issue of JAMA includes an article about changing recommendations for giving the polio vaccine in the United States.
Applicants' choice of a residency training program
Authors: W H Sledge, P J Leaf, M H Sacks
Journal: American Journal of Psychiatry (1987)

The authors present results from a survey of senior medical students in the class of 1981 concerning their selection of residency training programs in psychiatry. Generally, students were more influenced by clinical training opportunities and quality of life factors and not much influenced by the philosophy of the program. The implications of the findings are discussed from the perspectives of both advising and recruiting medical students.