tbuckley/cabot-search huggingface dataset:
STAT3-Driven, Aberrantly Expressed Lipoprotein Lipase Mediates Free Fatty Acid Metabolism in Chronic Lymphocytic Leukemia Cells
Authors: Uri Rozovski, Srdana Grgurevic, Carlos E. Bueso-Ramos, David M. Harris, Ping Li, Zhiming Liu, JI Yuan Wu, William Wierda, Jan A. Burger, Susan O'Brien, Nitin Jain, Alessandra Ferrajoli, Michael Keating, Zeev Estrov
Journal: Blood (2014)
AT-03ATYPICAL TERATOID RHABDOID TUMORS IN THE FIRST YEAR OF LIFE: SHOULD WE TREAT?
Authors: Mary Fossey, Haocheng Li, Anne-Sophie Carret, David Eisenstat, Adam Fleming, Chris Fryer, Cynthia Hawkins, Nada Jabado, Donna Johnston, Tanya Brown, Valerie Larouche, Katrin Scheinemann, Josee Brossard, Douglas Strother, Beverly Wilson, Shayna Zelcer, Eric Bouffet, Annie Huang, Lucie Lafay-Cousin
Journal: Neuro-Oncology (2016)
Outbreak of diarrhoeal illness in participants in an obstacle adventure race, Alpes-Maritimes, France, June 2015
Authors: Caroline Six, Samer Aboukais, Sandra Giron, Jean-Christophe D’Oliveira, Françoise Peloux-Petiot, Florian Franke, Hervé Terrien, Fabrice Dassonville, Joël Deniau, Katia Ambert-Balay, Thierry Chesnot, Raymond Ruimy, Michel Pélandakis, Patrick Basset, Manuel Munoz Rivero, Philippe Malfait
Journal: Eurosurveillance (2016)

An acute gastroenteritis (AG) outbreak occurred among participants in an obstacle race in France in the summer of 2015. An investigation in two phases was conducted to identify the source of infection and document the extent of the outbreak. First, a message on a social media website asked racers to report any symptoms by email to the Regional Health Agency of Provence-Alpes-Côte d'Azur. Second, a retrospective cross-sectional study was conducted through an interactive questionnaire for all participants, followed by an analytical study of potential risks factors. Of 8,229 persons registered, 1,264 adults reported AG resolved within 48 hours. Of adults who reported AG, 866 met the case definition. Age group, departure time and ingestion of mud were associated with AG. Twenty stool specimens tested negative for bacteria. All four stool samples tested for viruses were positive for norovirus genogroup I and genotype 2. No indicator bacteria for faecal contamination were found in drinking water but muddy water of ponds tested positive. The outbreak was possibly caused by human-to-human transmission of a norovirus introduced by one or more persons and transmitted through contaminated mud. Risks related to similar races should be assessed and recommendations be proposed to raise awareness among health authorities and organisers.
Case 26-1988
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Rita M. Linggood, Andrew E. Rosenberg
Journal: New England Journal of Medicine (1988)

Presentation of CaseA 40-year-old right-handed man was admitted to the hospital because of questionable recurrence of a brain tumor.He was well until 13 years earlier, when a grand-mal seizure occurred. Evaluation elsewhere included an electroencephalogram that was reported to be normal. One year later another grand-mal seizure occurred, and phenytoin and primidone were begun. The patient had no subsequent grand-mal seizures, although focal seizures involved the left arm and hand several times weekly. Ten years before entry a cranial computed tomographic (CT) scan was reported to show a low-density abnormality in the white matter of the right cerebral . . .
LMI-15BRAINSTEM GLIOMAS IN CHILDREN AT SRINAGARIND HOSPITAL
Authors: Patcharee Komvilaisak, Chaiyaphat Thaweerujirot, Amnat Kitkhuandee, Surapon Wiangnon, Arunee Jetrisuparb
Journal: Neuro-Oncology (2016)

The incidence of brainstem gliomas in children represents 15% of central nervous system tumors.Despite aggressive chemotherapy or radiation the 5-year survival rate ranges between 20-30%.The study is to review then determine prognostic factors for brainstem gliomas.All children diagnosed with brainstem gliomas confirmed by magnetic resonance imaging of the brain at Overall survival
Introduction of peanuts in younger siblings of children with peanut allergy: a prospective, double‐blinded assessment of risk, of diagnostic tests, and an analysis of patient preferences
Authors: P. Bégin, F. Graham, K. Killer, J. Paradis, L. Paradis, A. Des Roches
Journal: Allergy (2016)

The prevalence of peanut allergy in younger siblings of children with peanut allergy has been reported between 7% and 8.5%, but the anaphylactic risk at the time of introduction is currently unknown, which limits our ability to best counsel parents on this issue.To determine the risk of anaphylaxis and working parameters of allergy testing in this context.One hundred and fifty-four peanut-naïve younger siblings of peanut-allergic children underwent double-blinded skin testing, followed by parent-led peanut introduction. Questionnaires were dispensed to parents to investigate preferences with regard to peanut introduction in this subgroup.Eight participants (5.2%) presented unequivocal IgE-mediated reactions to peanut upon introduction, including five anaphylaxes. These participants were significantly older compared to the rest of the cohort (median 4.0 vs 1.9 years, P = 0.04). The negative predictive value of skin prick test with peanut extract and peanut butter and of specific IgE was 99%, 100%, and 100%, respectively. Six peanut-tolerant participants had positive peanut allergy tests. The option of introducing at home without prior skin testing was associated with high levels of anxiety (median 8.4 on 10-point Likert scale) when compared to supervised introduction (median 3.8, P < 0.0001) or home introduction after negative skin test (median 4.3, P < 0.0001).There is an increased risk of anaphylaxis upon peanut introduction in siblings of children with peanut allergy, and parents are reluctant to introduce at home without testing. Allergy testing prior to introduction is negative in over 90% of cases and carries a high negative predictive value.
Cardiac and Renovascular Complications in Type 2 Diabetes — Is There Hope?
Authors: Julie R. Ingelfinger, Clifford J. Rosen
Journal: New England Journal of Medicine (2016)

According to the current posting on the website of the World Health Organization, the worldwide prevalence of diabetes mellitus among persons 18 years of age or older is 8.5% and increasing. Most of those affected have type 2 diabetes, which has been epidemic for several decades and is associated with many complications, including premature macrovascular and microvascular diseases affecting the eyes, heart, kidneys, and the circulation. We know that diabetes is associated with major morbidity and mortality, with an estimated 1.5 million deaths in 2012 being directly due to diabetes.1Various approaches in the treatment of type 2 diabetes have . . .
Dengue and other Aedes-borne viruses: a threat to Europe?
Authors: Giovanni Rezza
Journal: Eurosurveillance (2016)

Preview this article: Dengue and other Aedes-borne viruses: a threat to Europe?, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/21/21/eurosurv-21-30238-1-1.gif
Venous thromboembolic events in advanced adenocarcinoma of the lung: impact on prognosis according to platinum therapies and presence of driver mutations
Authors: A. Delmonte, M. Mariotti, E. Scarpi, P. Ulivi, G. Gavelli, A. Rossi, D. Calistri, M.A. Burgio, A. Ragazzini, L. Crinò, D. Amadori
Journal: Annals of Oncology (2015)
BMA annual meeting: “Bizarre” conference motion could “stifle” debate on physician assisted dying
Authors: Zosia Kmietowicz
Journal: BMJ (2016)

A doctor who campaigns for assisted dying to be made legal in the United Kingdom has described as “bizarre” the scheduling of debates and motions on the subject at the BMA’s annual representatives meeting this week.

Jacky Davis is a consultant radiologist at the Whittington Hospital in London, chair of Healthcare Professionals for Assisted Dying, and a member of the BMA’s council and its medical ethics committee.

She told The BMJ that the timing of a motion calling for the conference to end all discussion of BMA policy on assisted dying on Tuesday 21 June could stifle a debate on care at the end of life and physician assisted suicide planned for Wednesday afternoon. …
Complete Regression of Multiple Pulmonary Metastases in a Patient with Advanced Renal Cell Carcinoma Treated by Occlusion of the Renal Artery with Subsequent Radical Nephrectomy and Progesterone
Authors: K. Dreikorn, B. Terwey, P. Drings, R. Horsch, H. Palmtag, W. Rössler
Journal: European Urology (1983)
Abstract 19833: A New Therapeutic Strategy for Refractory Cardiac Arrest Including Prehospital Ecmo: A Comparison Study
Authors: Lionel Lamhaut, Romain Jouffroy, Rado idialisoa, Alexandre Ellinger, Jean-Pierre Orsini, Alice Hutin, Murielle Jaffry, Christelle Dagron, Florian Loosli, Jerome Jouan, Kim An, Christian Spaulding, Pierre Carli
Journal: Circulation (2015)

Introduction: ECMO is a treatment of refractory cardiac arrest (RCA). The survival rate depends directly on the low flow (LF) period. To reduce LF we have implemented a new RCA management strategy. This work aims to evaluate the impact of this strategy on survival. Methods: This is an observational retrospective single-center study. The ECMO team is composed of a doctor, a nurse and a paramedic.The ethical committee validated the study. During period 1 (11 / 2011-12 / 2014), the strategy associated an ECMO team alert after 10 min of ALS, followed by the implementation of ECMO either in-hospital or out of hospital depending on the ECMO team availability. During period 2 (01-06 / 2015), the strategy associated an ECMO Team alert at the departure of the BLS Ambulance, with a dedicated ECMO team 24/24 H, and a systematic assessment for ECMO implementation either in hospital or out of hospital according to logistical constraints. A specific training was given to dispatch centers, and all ALS units. Qualitative variables were compared using the χ2 and Fisher exact tests, whereas quantitative variables were compared by Wilcoxon tests. Results: The results are in Table 1. The characteristics are similar. The significant results when comparing periods 1 and 2 include an increased survival rate, a decreased LF. Conclusions: The survival rate of RCA treated with ECMO depends on the LF. Unfortunately even by performing a single scoop and run strategy, an important proportion of patients can not be rapidly put on ECMO. We have developped a LF reduction strategy involving the implementation of ECMO either in hospital or in the out of hospital setting. The optimization of this strategy by an earlier alert, a dedicated ECMO team and training has a major significant impact on survival. This increase of survival is probably correlated to the decrease of the LF, especially in the prehospital group. These results need to be confirmed by a RCT comparing in hospital and out of hospital ECMO implementation.
Urinary phenethylamine response to d-amphetamine in 12 boys with attention deficit disorder
Authors: A J Zametkin, G L Brown, F Karoum, J L Rapoport, D H Langer, L W Chuang, R J Wyatt
Journal: American Journal of Psychiatry (1984)

Urinary phenethylamine (PEA), an endogenous amine similar to amphetamine in both molecular structure and pharmacological properties, was studied in 12 boys with attention deficit disorder with hyperactivity. d-Amphetamine and placebo were given for 14 days each in a counterbalanced crossover design; double-blind teacher behavior ratings and motor activity measurements were also obtained. Excretion of PEA, phenylacetic acid, creatinine, and d-amphetamine were measured. PEA was significantly increased and phenylacetic acid was unchanged after d-amphetamine administration, and change in PEA excretion correlated significantly with d-amphetamine excretion. There was no significant relationship between either clinical response to drug and change in PEA or phenylacetic acid excretion.
Safety and Efficacy Of Lomustine (CCNU) Substituting Carmustine (BCNU) In Conditioning For Autologous Haematopoietic Stem Cell Transplantation In Lymphoma. A Retrospective Analysis Of Two Patient Cohorts Over a Ten Year Period
Authors: Sven Armin Sommerfeld, Samar Kulkarni, David Kaye, Adrian Bloor
Journal: Blood (2013)
Intracellular pH steers vascular wall remodelling
Authors: Peter L. Hordijk
Journal: Cardiovascular Research (2016)

This editorial refers to ‘Na+, HCO3−-cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling’ by E. Boedtkjer et al. , pp. 227–239. 

Many vascular cell biologists will be well aware of the importance of agonist-induced changes in intracellular Ca2+ levels in vessel wall biology (controlling permeability, contractility, vascular stiffening, etc.). However, the impact of changes in intracellular pH (pHi) or local extracellular pH (pHo) is likely less broadly known. Changes in pHi/pHo drive myriad cellular functions and are regulated by a series of ion transporters, including the Na+/H+ transporters of the NHE family,1 and various types of Na+, HCO3− cotransporters of the Slc4 (Solute carrier 4) family.2

Variations in pHi can regulate protein–protein interactions by changing the protonation of amino acid side chains. In cell adhesion and migration, several examples of such regulation are known, involving actin-binding proteins and integrins. One such protein is talin, a large cytoskeletal protein which is concentrated in focal adhesions, sites of integrin-mediated attachment to the extracellular matrix. Protonation of talin reduces its affinity for F-actin, thus modulating …
HG-14OUTCOMES OF CHILDREN WITH NEWLY DIAGNOSED HIGH GRADE GLIOMAS TREATED WITH NIMOTUZUMAB<sup>®</sup>AND IRINOTECAN
Authors: Nongnuch Sirachainan, Samart Pakakasama, Usanarat Anurathapan, Ake Hansasuta, Attaporn Boonkerd, Mantana Dhanachai, Noppadol Larbcharoensub, Wipawi Klaisuban, Watinee Sanpote, Surapong Lertthammakiat, Nintita Sripaiboonkij, Apasri Lusawat, Rungrote Natesirinilkul, Suradej Hongeng
Journal: Neuro-Oncology (2016)
Coronary artery bypass graft or percutaneous coronary interventions in patients with diabetes: another nail in the coffin or “too close to call?”∗∗Editorials published in the Journal of the American College of Cardiologyreflect the views of the authors and do not necessarily represent the views of JACCor the American College of Cardiology.
Authors: Spencer B King
Journal: Journal of the American College of Cardiology (2001)
Repositioning compounds from cancer drug discovery to IPF: PI3K inhibition
Authors: Claudia A Staab-Weijnitz, Oliver Eickelberg
Journal: Thorax (2016)

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease that presents with a 5-year survival of 20–30%, hence with a mortality rate as high as many aggressive cancer types.1 According to a current analysis by the British Lung Foundation, the incidence of IPF in the UK has long been underestimated (https://www.blf.org.uk/). In addition, a recent systematic review shows that IPF incidence rates have increased worldwide.2 Two recently approved treatments for IPF, pirfenidone and nintedanib, have been shown to decelerate lung function decline in IPF, but do not halt disease progression or cure the disease.3 ,4 Hence, there is a clear need for novel therapeutic strategies, which manifests in (at time of writing) 46 registered interventional clinical studies for IPF (http://clinicaltrials.gov) and a continued quest for novel drug targets by the scientific community, fuelled by an increased understanding of IPF pathogenesis.5 Considering the substantial pathological heterogeneity of IPF and the multitude of dysregulated signalling pathways,6 it is likely that a successful cure of IPF will involve not a single, but several active agents, specifically targeting different pathomechanistic aspects of IPF.

With de novo drug development being an expensive and time-consuming process, it seems highly sensible to examine whether effective treatment for other disease entities with significant pathomechanistic overlap with IPF is suitable for IPF therapy as well. Notably, repositioning of drugs can shorten drug development time by >50% as phases like chemical optimisation, safety assessment or pharmacokinetic (PK) profiling can be bypassed. …
T-cell immunoglobulin and mucin domain 1 deficiency eliminates airway hyperreactivity triggered by the recognition of airway cell death
Authors: Hye Young Kim, Ya-Jen Chang, Ya-Ting Chuang, Hyun-Hee Lee, David I. Kasahara, Thomas Martin, Joyce T. Hsu, Paul B. Savage, Stephanie A. Shore, Gordon J. Freeman, Rosemarie H. DeKruyff, Dale T. Umetsu
Journal: Journal of Allergy and Clinical Immunology (2013)
The Preparation and Handling of Replicate Tissue Cultures for Quantitative Studies
Authors: Virginia J. Evans, Wilton R. Earle, Katherine K. Sanford, John E. Shannon, Helen K. Waltz
Journal: JNCI Journal of the National Cancer Institute (1951)

Journal Article The Preparation and Handling of Replicate Tissue Cultures for Quantitative Studies Get access Virginia J. Evans, Virginia J. Evans Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle, Wilton R. Earle Search for other works by this author on: Oxford Academic PubMed Google Scholar Katherine K. Sanford, Katherine K. Sanford Search for other works by this author on: Oxford Academic PubMed Google Scholar John E. Shannon, John E. Shannon Search for other works by this author on: Oxford Academic PubMed Google Scholar Helen K. Waltz Helen K. Waltz National Cancer Institute, National Institutes of Health, U. S. Public Health Service, Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 5, April 1951, Pages 907–927, https://doi.org/10.1093/jnci/11.5.907 Published: 01 April 1951 Article history Received: 17 October 1950 Published: 01 April 1951
Large ongoing outbreak of infection with Salmonella Typhimurium U292 in Denmark, February-July 2008
Authors: S Ethelberg, A Wingstrand, T Jensen, G Sørensen, L Muller, E M Nielsen, K Mølbak
Journal: Eurosurveillance (2008)

Denmark is currently experiencing an unusually large outbreak of gastrointestinal illness caused by Salmonella Typhimurium, phage type U292. The outbreak was discovered in early April by molecular typing (MLVA typing) of S. Typhimurium isolates at the Statens Serum Institut (SSI); the first patients reported onset on illness in February, but the number of reported cases has been particularly high in May and June (Figure 1). There are currently (as of 7 July) 366 confirmed cases, effectively making this the largest outbreak of salmonella infections in Denmark since 1993 [1].
HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery
Authors: Lingling Geng, Zihua Wang, Xiangqian Jia, Qiuju Han, Zhichu Xiang, Dan Li, Xiaoliang Yang, Di Zhang, Xiangli Bu, Weizhi Wang, Zhiyuan Hu, Qiaojun Fang
Journal: Theranostics (2016)

Herein, computational-aided one-bead-one-compound (OBOC) peptide library design combined with in situ single-bead sequencing microarray methods were successfully applied in screening peptides targeting at human epidermal growth factor receptor-2 (HER2), a biomarker of human breast cancer.As a result, 72 novel peptides clustered into three sequence motifs which are PYL***NP, YYL***NP and PPL***NP were acquired.Particularly one of the peptides, P51, has nanomolar affinity and high specificity for HER2 in ex vivo and in vivo tests.Moreover, doxorubicin (DOX)-loaded liposome nanoparticles were modified with peptide P51 or P25 and demonstrated to improve the targeted delivery against HER2 positive cells.Our study provides an efficient peptide screening method with a combination of techniques and the novel screened peptides with a clear binding site on HER2 can be used as probes for tumor imaging and targeted drug delivery.
Brief Communication: Friend Leukemia: Rapid Development of Erythropoietin-Independent Hematopoietic Precursors2
Authors: Julius S. Horoszewicz, Susan S. Leong, William A. Carter
Journal: JNCI Journal of the National Cancer Institute (1975)

Infection of mice with the polycythemia-inducing strain of Friend leukemia virus caused a rapid emergence of new erythroid precursor cells. These cells which, in the absence of erythropoietin, proliferated in vitro to form colonies and even differnetiated, quickly out-numbered the usual erythropoietin-dependent hematopoietic elements in bone marrow and spleen. Ultimately, the marrow and spleen were probably totally repopulated with this erythropoietin-independent cell.
Dose-related biphasic effect of prolyl-leucyl-glycinamide (MIF-I) in depression
Authors: R H Ehrensing, A J Kastin
Journal: American Journal of Psychiatry (1978)

Five of 8 patients with unipolar or bipolar endogenous depressions taking prolyl-leucyl-glycinamide (MIF-I), 75 mg/day, showed substantial improvement within a few days of beginning treatment compared with similar improvement in only 1 of 10 receiving 750 mg/day of MIF-I and only 1 of 5 patients taking placebo. The lower dose of MIF-I was associated with significantly greater improvement than both the higher dose and placebo on all of the rating scales used. The authors suggest that an even lower dose of MIF-I, on the order of 0.1 mg/kg, may have a greater effect as an antidepressant.
LG-21IN VIVO EVOLUTION OF A NOVEL PATIENT-DERIVED ORTHOTOPIC XENOGRAFT (PDOX) MOUSE MODELS OF PEDIATRIC PLEOMORPHIC XANTHOASTROCYTOMA HARBORING BRAF V600E MUTATION
Authors: Mari Kogiso, Lin Qi, Frank Braun, Xiumei Zhao, Zhigang Liu, Holly Lindsay, Yuchen Du, Huiyuan Zhang, Sibo Zhao, Ching-Hua Liu, Vidya Mehta, Xiaoyun Shen, Jeffrey Murray, Laszlo Perlaky, Jack Su, Patricia Baxter, Adekunle Adesina, Donald Parsons, Murali Chintagumpala, Xinyan Lu, Xiao-Nan Li
Journal: Neuro-Oncology (2016)
Gonadotropin response to synthetic gonadotropin hormone-releasing hormone (GnRH) in heroin addicts
Authors: F Brambilla, L Resele, D De Maio, P Nobile
Journal: American Journal of Psychiatry (1979)

To determine whether the pituitary-gonadal deficiency in heroin addicts is related to heroin's effect on the hypothalamus, the authors administered gonadotropin hormone-releasing hormone (GnRH) to 10 male heroin addicts and 5 controls and measured follicle-stimulating hormone (FSH) and luteinizing hormone (LH) response. Basal FSH and LH levels were significantly lower in addicts; after GnRH stimulation the addicts' FSH and LH values increased but not significantly compared to controls. The difference between the two groups' response was highly significant. The authors suggest that heroin causes an incomplete blocking of gonadotropin secretion at the pituitary level, inducing a hypophyseal-gonadal deficiency and a long-lasting depletion of the endogenous releasing factor, which accounts for the reduced response to GnRH.
Race and Health Care
Authors: C S Bryan
Journal: JAMA (2002)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal