tbuckley/cabot-search huggingface dataset:
PTH-045a The Accuracy of Wavstat Version 4 Optical Biopsy Forceps in Characterising Colorectal Polyps Less 10 MM: A Prospective Blinded Study: Abstract PTH-045a Table 1
Authors: N Mohammed, R Sood, SV Venkatachalapathy, F Abid, N Burr, J Meadows, J Carbonell, P Luthra, O Rotimi, V Subramanian
Journal: Gut (2016)

<h3>Introduction</h3> WavSTAT version 4 is an optical biopsy system designed for prediction of histology based on laser induced autofluorescence spectroscopy. The primary aim of this study was to demonstrate the accuracy of WavSTAT4 in characterising colorectal polyps &lt;10 mm. The secondary aim was to compare the real time diagnostic performance of WavSTAT4 with NBI and a combination of endoscopic and WavSTAT assessments. <h3>Methods</h3> Adult patients referred for lower gastrointestinal endoscopy were included in the study. Patients with inflammatory bowel disease or colorectal cancer were excluded. Polyps sized &lt;10 mm were assessed in real time by high definition white light, NBI and WavSTAT4 optical biopsy forceps. Histopathological specimens were read separately by two expert GI pathologists blinded to the results of the NBI and WavSTAT assessments. <h3>Results</h3> 156 polyps were found in 70 patients (Males-44, females-27, average age 65). After applying exclusion criteria a total of 126 polyps &lt;10 mm were included in the analysis. Wavstat4 had a NPV of 96.8% but lacked specificity. Endoscopic assessment had a NPV of 91% and was more specific. Since the specificity of WavSTAT was poor mainly for hyperplastic recto-sigmoid polyps we evaluated an algorithmic approach where we classified the polyps according to the WavSTAT4 result when proximal to the recto-sigmoid junction. We classed them according to the endoscopic classification if WavSTAT4 predicted an adenomatous polyp in the recto-sigmoid area. This combined algorithmic approach met the PIVI thresholds and had a NPV of 95.8% and predicted 100% of surveillance intervals correctly. <h3>Conclusion</h3> WavSTAT version 4 has a high NPV for characterising colorectal polyps less than 10 mm in size but only predicts surveillance intervals correctly in 81.2% of patients. . An algorithmic approach combining Wavstat4 and endoscopic assessment had a high NPV with accurate prediction of surveillance intervals. <h3>Disclosure of Interest</h3> None Declared
MR-Proanp and VEGF As Markers of Response to MEL-DEX Treatment in Systemic AL Amyloidosis
Authors: Alessandro Moscetti, Giusy Antolino, Federica Resci, Daniela De Benedittis, Virginia Naso, Maria Paola Bianchi, Beatrice Musumeci, Francescaromana Festuccia, Gerardo Salerno, Maria Teresa Corsetti, Patrizia Cardelli, Giovanna Ferranti, Giacinto La Verde
Journal: Blood (2012)
Expression and Targeted Inhibition of the Immunoregulatory Carbohydrate-Binding Lectin, Galectin 1, in EBV-Driven Post-Transplant Lymphoproliferative Disorders.
Authors: Jing Ouyang, Przemyslaw Juszczynski, Evan O'Donnell, Myriam Armant, Scott J. Rodig, Kunihiko Takeyama, Stefano Monti, Gabriel Rabinovich, Jeffery Lorne Kutok, Jerome Ritz, Margaret A. Shipp
Journal: Blood (2009)
Comprehensive Geriatric Assessment-Adapted Chemotherapy in Elderly Patients (&gt;70 years) with Diffuse Large B-Cell Non-Hodgkin's Lymphoma (DLBCL): Final Results and Long Term Follow-up.
Authors: Umberto Tirelli, Lucia Fratino, Monica Balzarotti, Lilj Uziel, Annalisa Giacalone, Andres Ferreri, Armando Santoro, Michele Spina
Journal: Blood (2009)
Rapid and Continued T-Cell Differentiation into Long-term Effector and Memory Stem Cells in Vaccinated Melanoma Patients
Authors: Philippe O. Gannon, Petra Baumgaertner, Alexandre Huber, Emanuela M. Iancu, Laurène Cagnon, Samia Abed Maillard, Hélène Maby-El Hajjami, Daniel E. Speiser, Nathalie Rufer
Journal: Clinical Cancer Research (2016)

Purpose: Patients with cancer benefit increasingly from T-cell-based therapies, such as adoptive T-cell transfer, checkpoint blockade, or vaccination. We have previously shown that serial vaccinations with Melan-AMART-126-35 peptide, CpG-B, and incomplete Freund adjuvant (IFA) generated robust tumor-specific CD8 T-cell responses in patients with melanoma. Here, we describe the detailed kinetics of early- and long-term establishment of T-cell frequency, differentiation (into memory and effector cells), polyfunctionality, and clonotype repertoire induced by vaccination.Experimental Design: Twenty-nine patients with melanoma were treated with multiple monthly subcutaneous vaccinations consisting of CpG-B, and either the native/EAA (n = 13) or the analogue/ELA (n = 16) Melan-AMART-126-35 peptide emulsified in IFA. Phenotypes and functionality of circulating Melan-A-specific CD8 T cells were assessed directly ex vivo by multiparameter flow cytometry, and TCR clonotypes were determined ex vivo by mRNA transcript analyses of individually sorted cells.Results: Our results highlight the determining impact of the initial vaccine injections on the rapid and strong induction of differentiated effector T cells in both patient cohorts. Moreover, long-term polyfunctional effector T-cell responses were associated with expansion of stem cell-like memory T cells over time along vaccination. Dominant TCR clonotypes emerged early and persisted throughout the entire period of observation. Interestingly, one highly dominant clonotype was found shared between memory and effector subsets.Conclusions: Peptide/CpG-B/IFA vaccination induced powerful long-term T-cell responses with robust effector cells and stem cell-like memory cells. These results support the further development of CpG-B-based cancer vaccines, either alone or as specific component of combination therapies. Clin Cancer Res; 23(13); 3285-96. ©2016 AACR.
Enhancing Neutrophil Differentiation - A Novel Role for the Death-Associated Protein Kinase 2 (DAPK2).
Authors: Mattia Rizzi, Christian Britschgi, Mario P. Tschan, Tobias J. Grob, Barbara Huegli, Nicolas Leupin, Beatrice U. Mueller, Andrew Ziemiecki, Bruce E. Torbett, Martin F. Fey, Andreas Tobler
Journal: Blood (2005)
Clinical Outcomes According to Genomic Abnormalities in 566 Newly Diagnosed Multiple Myeloma Patients Treated with Bortezomib-Based Regimens.
Authors: Michele Cavo, Sara Bringhen, Nicoletta Testoni, Paola Omedè, Giulia Marzocchi, Marina Ruggeri, Sandra Durante, Francesco Di Raimondo, Davide Rossi, Ausilia Gorgone, Francesca Patriarca, Maria Teresa Petrucci, Silvia Buttignol, Anna Levi, Massimo Offidani, Chiara Nozzoli, Roberto Ria, Barbara Olivero, Monica Galli, Vittorio Montefusco, Vincenzo Callea, Antonietta Falcone, Antonio De Vivo, Mario Boccadoro, Carolina Terragna, Antonio Palumbo
Journal: Blood (2009)
Aromatic compounds from an aqueous extract of “ban lan gen” and their antiviral activities
Authors: Yufeng Liu, Minghua Chen, Qinglan Guo, Yuhuan Li, Jiandong Jiang, Jiangong Shi
Journal: Acta Pharmaceutica Sinica B (2016)

A pair of new diphenyl glycerol ether enantiomers (-)-1 and (+)-1 and two new methyl benzamidobenzoates 2 and 3, named (-)-(R)- and (+)-(S)-isatindigotrioic acid [(-)-1 and (+)-1] and isatindigoticamides A (2) and B (3), respectively, were isolated from an aqueous decoction of the roots of Isatis indigotica (ban lan gen). Their structures were elucidated by spectroscopic data analysis including 2D NMR experiments. The absolute configurations of (-)-1 and (+)-1 were assigned based on the CD exciton chirality method. Compounds 2 and 3 exhibited antiviral activities against HSV-1 with IC50 values of 4.87 and 25.87 μmol/L, respectively. Compound 2 was also found active against Coxsackie virus B3 and LPS-induced NO production.
Comparative Analysis of Sibling Donor Reduced Intensity Conditioning Regimen for High Risk AML/MDS Using Anti-Thymocyte Globulin Versus Alemtuzumab for T-Cell Depletion.
Authors: ZiYi Lim, Sarah Bennett, Aloysius YL Ho, Austin G Kulasekararaj, Sunil Gupta, Michelle Kenyon, Janet Hayden, Judith C W Marsh, Antonio Pagliuca, Ghulam J Mufti
Journal: Blood (2009)
A Pilot Study of Reduced Toxicity Conditioning (RTC) with Busulfan (Bu), Fludarabine (Flu), and Alemtuzumab Followed by Allogeneic Stem Cell Transplantation (AlloSCT) to Induce Sustained Mixed Donor Chimerism In Patients with Symptomatic Sickle Cell Disease (SCD)
Authors: Monica Bhatia, Mark B Geyer, Courtney Baker, Erin Morris, Deirdre Duffy, Diane George, James H Garvin, Prakash Satwani, Joseph Schwartz, Sandra Foley, Ria Hawks, Elana Hamburger-Smilow, Lee Ann Baxter-Lowe, Mitchell S. Cairo
Journal: Blood (2010)
Disthyroidism during immune checkpoints inhibitors treatment: toxicity or something more?
Authors: D. Signorelli, M.S. Cona, G. Lo Russo, C. Proto, M. Vitali, M. Macerelli, F. Agustoni, A. Indini, M. Platania, N. Zilembo, M.C. Garassino, L. Di Guardo, M. Del Vecchio, M. Magni, V. Sinno, E. Seregni, M. Di Nicola, F.G. de Braud
Journal: Annals of Oncology (2015)
RUNX1-Induced Silencing of Non-Muscle Myosin Iib (MYH10) Is Required for Megakaryocyte Polyploidization
Authors: Dominique Bluteau, Larissa Lordier, Iléana Antony-Debré, Abdelali Jalil, Céline Legrand, Philippe Rameau, Olivier Bluteau, Dima Jouni, Thomas Mercher, Catherine Leon, Christian Gachet, Najet Debili, William Vainchenker, Yunhua Chang, Hana Raslova
Journal: Blood (2011)
C/EBPα-Induced MicroRNA 30c Inactivates Notch1 During Granulopoiesis and Is Downregulated In Acute Myeloid Leukemia
Authors: Christiane Katzerke, Vikas Madan, Dennis Gerloff, Daniela Braeuer-Hartmann, Jens-Uwe Hartmann, Carsten Mueller-Tidow, Daniel G. Tenen, Dietger Niederwieser, Gerhard Behre
Journal: Blood (2011)
Thalidomide Consolidation Post Autologous Stem Cell Transplant (ASCT) For Multiple Myeloma (MM) Is Cost-Effective With Durable Survival Benefit At 5 Years Post Randomisation: Final Analysis Of The ALLG MM6 Study
Authors: Anna Kalff, Nola Kennedy, Angela Smiley, H. Miles Prince, Andrew W. Roberts, Kenneth F Bradstock, Richard De Abreu Lourenco, Andrew Spencer
Journal: Blood (2013)
Circulating CLA<sup>+</sup>T cells in atopic dermatitis and their possible role as peripheral biomarkers
Authors: T. Czarnowicki, L. F. Santamaria-Babí, E. Guttman-Yassky
Journal: Allergy (2016)

Cutaneous lymphocyte-associated antigen (CLA+) T cells are specialized for skin homing and represent the main T-cell population in atopic dermatitis (AD) lesions. CLA+ is expressed on the surface of circulating CD45RO+ memory T cells and most skin-infiltrating T cells. Mechanistic studies and thus treatment advancements are limited by the need of large number of skin biopsies. Circulating CLA+ T cells may be a reliable surrogate marker of the inflammatory events occurring in the skin, and thus, the evaluation of CLA+ T cells in the blood may eliminate the need for skin biopsies. Preliminary work in AD has established that disease-associated T-cell abnormalities can be approached by either a study of skin lesions or activated CLA+ T-cell subsets in peripheral blood. Future studies in adults and children, across different skin disorders, correlating blood and skin phenotypes and determining skin-homing T-cell functional properties are needed to establish whether CLA+ memory subsets can be used as biomarkers and a substitute for skin biopsies. This review summarizes the latest advancements reached on circulating CLA+ in AD and the great potential they harbor in understanding AD mechanisms.
OP0112 Effect of Comedication with Conventional Synthetic Dmards on Tnf Inhibitors-Retention in Patients with Spondyloarthritis: A Prospective Cohort
Authors: A. Sepriano, S. Ramiro, D. van der Heijde, P. Άvila-Ribeiro, R. Fonseca, J. Borges, L. Teixeira, P. Carvalho, M. Cerqueira, J. Neves, T. Meirinhos, A. Barcelos, G. Sequeira, M.J. Salvador, J.A. Canas da Silva, H. Santos, M. Bernardes, E. Vieira-Sousa, H. Canhão, J. Branco, F. Pimentel-Santos, R. Landewé
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The effects of comedication with conventional synthetic disease modifying antirheumatic drugs (csDMARDs) on TNF inhibitors (TNFi)-retention in spondyloarthritis (SpA), are inconclusive. Results from previous observational studies may have easily led to spurious conclusions, since confounding, especially "confounding by indication", was not fully addressed. <h3>Objectives</h3> To evaluate if comedication with csDMARD influences TNFi-retention in patients with SpA, while performing a comprehensive set of adjustments to best handle confounding. <h3>Methods</h3> Patients with SpA (according to their treating rheumatologists) from the Rheumatic Diseases Portuguese Register (Reuma.pt), with first TNFi started between 2001 and 2014 were included in this prospective, multicenter, cohort study. Our main outcome was time to first TNFi discontinuation. Cox-regression was used to estimate the effect of csDMARD comedication on TNFi-retention in two types of models, one including baseline (time-fixed) variables and the other with time-varying variables, including socio-demographic features, measures of disease activity, physical function and co-treatment with other drugs (NSAIDs and oral steroids). To control for possible "confounding by indication", the effect of csDMARD comedication on TNFi-retention was also tested after propensity score (PS)-adjustment. <h3>Results</h3> In total, 954 patients (mean (SD) age 41.5 (12.0) years; 59.6% males; 13.7 (10.4) years of disease duration) were included and 289 (30.3%) discontinued their first TNFi after a median follow-up time of 2.5 years (range: 0.08–13 years). A large proportion of patients were treated with csDMARDs at baseline (389; 41%). Inefficacy was the most common reason for TNFi discontinuation (55.7%), followed by adverse events (31.1%). In the multivariable analysis comedication with csDMARDs had no effect on TNFi-retention, neither in the baseline model (HR: 0.83; 95% CI: 0.59; 1.16) (figure A) nor during follow-up adjusting for time-varying covariates (HR: 1.13; 95% CI: 0.71; 1.80). The effect of csDMARDs remained not statistically significant after PS-adjustment (figure B). <h3>Conclusions</h3> Comedication with csDMARDs does not prolong TNFi-retention in SpA patients in clinical practice suggesting no benefit in the concomitant use of these drugs. <h3>Disclosure of Interest</h3> None declared
ANALYSIS OF LOOPING PATTERNS IN COLONOSCOPY USING SCOPEGUIDE; THEIR RELATION TO COMPLETION TIMES AND CONFIGURATIONS IN CADAVERIC COLONS
Authors: J Lam, J Wilkinson, Cecilia Brassett, J Brown
Journal: Gut (2016)

Introduction  ScopeGuide™ magnetic imaging provides a real-time 3 D reconstruction of the position and configuration of the endoscope within the colon, and enables rapid identification and resolution of newly-formed loops. Previous studies have shown benefits in terms of completion rates and comfort scores and the technology has an established role in training.1  This study aims to analyse the looping patterns of the sigmoid and transverse colons during colonoscopy, their relation to completion times in experienced hands and the configurations of these colonic segments in undisturbed cadavers.  Methods  103 ScopeGuide™ videos of consecutive normal colonoscopies performed by one bowel cancer screening (BCS) colonoscopist with comfort scores on the BCS 50th centile were analysed. Repeated inspection of the videos enabled standard definitions to be introduced for looping patterns of the sigmoid and transverse colons. In addition, the configurations of the sigmoid and transverse segments of the colons in the undisturbed abdomens of 81 cadavers were investigated and their relation to the colonoscopic data explored. The association between completion time and the different configurations seen at colonoscopy were analysed with a one-way ANOVA and sex differences in mobility in live cases and cadavers by Fisher’s exact test.  Results  For the colonoscopies, significant sex differences were found in both sigmoid (p = 0.0233) and transverse (p = 0.0006) colonic configurations. While sigmoid loops in this sample conformed to the usual four categories of straight, N-, alpha and reverse alpha loops, a supplementary classification is proposed for the transverse colon, with straight, intermediate and deep loops which are distinct and clearly defined. In the cadaveric data, there was a significant sex difference in the mobility of the transverse colon (p   Conclusion  This study supports the role of ScopeGuide™ in real time analysis of colonic looping patterns and introduces a supplementary classification for transverse loops. There are significant sex differences between the transverse looping configurations for both in vivo and cadaveric colons. However, no significant correlation between looping configurations and completion times were observed in experienced hands. Familiarity with the looping patterns and the techniques for resolution may explain these results which remain a significant challenge to intermediate trainees.  Reference  1 Holme et al. Magnetic endoscopic imaging versus standard colonoscopy in a routine colonoscopy setting: a randomised, controlled trial. Gastrointest Endosc 2011 Jun;73(6):1215–22.  Disclosure of Interest  None Declared
Loss of p300 accelerates MDS-associated leukemogenesis
Authors: G Cheng, F Liu, T Asai, F Lai, N Man, H Xu, S Chen, S Greenblatt, P-J Hamard, K Ando, X Chen, L Wang, C Martinez, M Tadi, L Wang, M Xu, F-C Yang, R Shiekhattar, S D Nimer
Journal: Leukemia (2016)
AB1037 Effectiveness of Conventional Dmard Therapy in Patients with Rheumatoid Arthritis and Succeeding Cost-Savings for A Health System by Diminishing Use of Biological Therapy
Authors: P. Santos-Moreno, L. Villarreal, G. Ballesteros, J. Bello, E. Castillo, R. Giraldo, D. Gomez, A. Aza, A. Lopez, A. Cardozo, N. Palacio, C. Castro, D. Buitrago-Garcia
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Biological therapy is useful to prevent clinical and radiological progression in patients with rheumatoid arthritis (RA) but is associated with high costs and has impacted budget in Colombian health system. Consequently, it is important to develop strategies to achieve positive outcomes in RA patients and at the same time to obtain cost-savings for health system. <h3>Objectives</h3> We describe effectiveness of conventional DMARD therapy in RA patients with moderate-severe disease activity, usefulness of Treat to Target (T2T) strategy with a multidisciplinary care team (MCT) model and subsequently cost-savings obtained. <h3>Methods</h3> We conducted a real-world, retrospective, cross-sectional study. We included patients who had moderate-severe disease activity; these patients were potential candidates for biologic therapy because were using conventional treatment; they were followed-up and treated according to T2T and MCT model. Clinical follow-up was designed by the authors according to DAS28 as follows: every 3–5 weeks (DAS28 &gt;5.1), every 7–9 weeks (DAS28 ≥3.1 and ≤5.1), and every 11–13 weeks (DAS28 &lt;3.1); therapy had to be adjusted with DAS28 &gt;3.2 unless patient9s conditions don9t permit it. The aim of the study was to evaluate patients who were in moderate-severe disease activity and reached low disease activity or remission impacting on health costs. Descriptive epidemiology was done, the medians were analyzed using t-Student by performing a normality test for DAS28 distribution; the disease activity was analyzed using Pearson9s statistics. <h3>Results</h3> 526 patients were included, mean age 63.5±11.8, 424 (80%) female and 102 (20%) male. These patients had a DAS28 on average 4.5±1 at beginning and after 24 months 410 patients (78%) got remission/low disease activity status with a mean DAS28 2.57±1. The costs of biological therapy in Colombia finishing 2015 on average were $7,725 US dollars/year/patient, and taking into account that 410 patients in moderate-severe disease activity who were candidates to biologic treatment and reached at least low disease activity, the amount in costs-savings projected for health system by preventing early use of biologics was approximately $3,167,551million dollars/year, ranging between the cheapest biological and the most expensive ($4,878 and $12,774 US dollars/year respectively). <h3>Conclusions</h3> This study showed that it is possible to decrease disease activity and obtain a significant cost-reduction in treatment of RA by using conventional DMARDs in a model with therapeutic goals like T2T and optimizing a multidisciplinary approach. <h3>Disclosure of Interest</h3> None declared
Molecular Mimicry in the Adulteration of Heparins. Chemical Basis for the Development of Oversulfated Chondroitin Sulfate and Related Contaminants
Authors: Jawed Fareed, Rakesh Wahi, Indermohan Thethi, Debra Hoppensteadt, Vinod Bansal, Jeanine M. Walenga, Harry L. Messmore
Journal: Blood (2011)
“Secondary MGUS” After High-Dose Melphalan and Autologous Hematopoietic Progenitor Cell Transplantation In Multiple Myeloma: A Matter of Undetermined Significance.
Authors: Greg V. Manson, Erica L. Campagnaro, Pingfu Fu, Scott R Sommers, Christine A Curtis, Anna Balog, David Kaplan, Hillard M. Lazarus
Journal: Blood (2010)
PTH-155 Evidence for a ‘Weekend Effect’ in the Management of Acute GI Bleeding in a Central London Teaching Hospital
Authors: S Carlson, J Stephens, H Nightingale, N Direkze, J Hoare, B Graf
Journal: Gut (2016)

<h3>Introduction</h3> NICE guidance recommends that endoscopy should be performed within 24 hours of admission with a non-severe upper gastrointestinal bleed (UGIB). This audit reviewed cases over a six month period in a central London teaching hospital to establish compliance. We also evaluated whether there was a greater delay at weekends compared to weekdays. <h3>Methods</h3> 41 patients were identified with a non-variceal UGIB. Patient notes were reviewed to collect data on arrival time, endoscopy time and findings, and clinical details to calculate a Rockall score. Arrival and endoscopy time were used to calculate time to endoscopy; these figures were used to compare weekend versus weekday performance. <h3>Results</h3> Rockall scores were normally distributed with mean of 3.8, median 4 and mode 4. The range was 0–10. Mean time from admission to endoscopy was 21 hours. 61% of patients had an endoscopy within the first 24 hours of admission, and therefore met NICE guidance. The mean Rockall score of patients receiving endoscopy within 24 hours was 4.32. Those whose endoscopy occurred later than 24 hours had a mean score of 3.3. Mean time to endoscopy in those admitted on weekdays was 17 hours, with 66.6% undergoing endoscopy within 24 hours. The range of waiting times was 1–48 hours. In comparison, mean time to endoscopy at weekends was 30 hours with 60% undergoing endoscopy within 24 hours. The range was 10–75 hours. 2 patients (5.1%) had a second UGIB during admission. Both of those were inpatients for other reasons at the time of their first bleed. <h3>Conclusion</h3> Only 61% of patients underwent endoscopy within 24 hours of admission. However those who got earlier endoscopies had higher mean Rockall scores which suggest they were prioritised appropriately. Patients admitted at the weekend waited longer on average for their endoscopy and even the quickest weekend endoscopy was 10 hours after arrival. There is undoubtedly some “weekend effect” seen. However, the percentage meeting the NICE guidance is similar (60% versus 66%). The longest weekend wait was 75 hours compared to 48 on weekdays,presumably as low-risk patients have a longer wait out of hours. The reason for the delay is likely multifactorial, but significantly the endoscopy department is closed over the weekend. To scope patients the on call endoscopist competes with emergency theatre lists. In a busy London hospital with a Major Trauma Centre and General, Orthopaedic and Vascular surgery, a sub-acute GI bleed will not be prioritised. The fundamental question for the hospital is whether the endoscopy department should open at the weekend. Costing has put this at almost £100 000 per annum (including a seven day out of hours on call nurse) to offer just an emergency service. <h3>Disclosure of Interest</h3> None Declared