tbuckley/cabot-search huggingface dataset:
CÁPSULA ENDOSCÓPICA COMO HERRAMIENTA DIAGNÓSTICA EN LA SOSPECHA DE ENFERMEDAD INFLAMATORIA INTESTINAL: ¿ES RENTABLE?
Authors: F Mesonero Gismero, L Crespo Perez, J Martínez-Gonzalez, S Parejo Carbonell, V Busto Bea, C Senosiain Lalastra, C García-Sanchez, A Cano Ruiz, J Graus Morales, D Boixeda de Miquel
Journal: Endoscopy (2012)

La cápsula endoscópica (CE) emerge como herramienta diagnóstica de la enfermedad inflamatoria intestinal (EII); siendo segura, no invasiva y sensible en la detección de lesiones no evidenciadas en pruebas rutinarias. Objetivo: Valorar la rentabilidad diagnóstica de la CE en una serie hospitalaria de pacientes con sospecha de EII (clínica y serológica) sin diagnóstico confirmado con las pruebas habituales. Definir los hallazgos y su correlación con las pruebas habituales. Material y método: Revisión retrospectiva de las CE realizadas entre 2010–2011, donde la colonoscopia, biopsias y el tránsito intestinal fueron inconcluyentes. Recogemos datos epidemiológicos y de las exploraciones. Consideramos CE sugestivas aquellas con aftas, úlceras y/o estenosis sin otra causa atribuible. Correlacionamos los hallazgos obtenidos. Resultados: Se realizó CE a 30 pacientes (53% mujeres con edad media 38±18 años). El 93,5% fueron valorables; siendo patológicas un 48%: aftas y úlceras (93%, el 85% en íleon terminal) y estenosis (7%). El 97% tenían colonoscopia previa: normal (45%, 33% con ileoscopia fallida) y patológica (55%, 47% colitis inespecífica, 47% eritema valvular, 6% estenosis colon); cuyas biopsias fueron inconcluyentes (71%), normales (19%) o sugestivas de colitis ulcerosa (10%). Un 87% tenían un tránsito intestinal: patológico (29,6%, 87% ileitis terminal, 13% estenosis ileal). Hubo correlación con la CE en el 64% de estos. En un 35,7%, la CE fue la única exploración que evidenció patología compatible. Se reportó una retención endoscópica que se resolvió espontáneamente. Conclusiones: – La CE es una exploración segura y útil en el diagnóstico de EII. – Existe correlación con las exploraciones habituales, aunque en un 35,7% fue la única prueba que mostró patología. – La ileoscopia es fundamental si sospechamos EII (3 de las ileoscopias realizadas a posteriori con CE patológica mostraron lesiones). – Sería rentable solicitar una CE en la sospecha de EII cuando las exploraciones rutinarias no han sido concluyentes.
Deficient Sympathetic Nervous Response in Familial Dysautonomia
Authors: Michael G. Ziegler, C. Raymond Lake, Irwin J. Kopin
Journal: New England Journal of Medicine (1976)

Norepinephrine concentration and dopamine-beta-hydroxylase activity were measured in the plasma of 10 dysautonomic patients and 10 normal subjects while they were reclining, standing and exercising. While reclining, dysautonomic patients had normal norepinephrine concentrations and blood pressure, but after standing they did not have a normal increase in their levels of norepinephrine (P less than 0.005), dopamine-beta-hydroxylase (P less than 0.05) or plasma protein concentration (P less than 0.01); they became hypotensive. In reclining dysautonomic patients there appeared to be a correlation between blood pressure and plasma norepinephrine concentration. These data support the view that hypertension and hypotension in dysautonomia are related to the rate of norepinephrine release.
Case 24-2010
Authors: Andrea K. Ng, Jeremy S. Abramson, Subba R. Digumarthy, Jason S. Reingold, James R. Stone
Journal: New England Journal of Medicine (2010)

A 56-year-old woman was admitted because of the sudden onset of dyspnea and hypotension. At 16 years of age, she had received combination chemotherapy and extended-field radiation therapy for Hodgkin's lymphoma. On admission, an electrocardiogram showed an acute myocardial infarction. A stent was placed, but hypotension and acidosis persisted, and the patient died.
Screening Recommendations for Hepatitis B Virus Infection
Authors: Daihung Do, April W. Armstrong
Journal: JAMA Dermatology (2016)

What are the screening guidelines for hepatitis B virus (HBV) infection for asymptomatic, nonpregnant adolescents and adults in the United States?Patients with a high risk of infection, such as those with human immunodeficiency virus (HIV), who use injection drugs, or who live in a household where someone is infected with HBV; men who have sex with men; or patients who come from countries with a high prevalence of HBV infection, should be screened.
Abstract 2075: MicroRNA-21 expression levels are accompanied by respective alterations in pdcd4 protein levels in non-small cell lung cancer
Authors: Ioanna S. Sourvinou, Athina Markou, Loukas Kaklamanis, Emily G. Tsaroucha, Iwata Ozaki, Sachiko Matsuhashi, Evi S. Lianidou
Journal: Cancer Research (2010)

Abstract Introduction: MicroRNA-21 is a well characterized cancer associated miRNA as it has been found overexpressed in nine types of solid tumors and in other malignancies. The role of miR-21 is related with diverse carcinogenesis processes. The downregulation of tumor suppressor genes through the overexpression of miR-21 has been demonstrated for PTEN and TPM1. Very recently, it was revealed that programmed cell death 4 (PDCD4) is another target of miR-21 in colon and breast cancer cell lines. As it has not been yet studied the correlation between miR-21 and PDCD4 levels in clinical samples, we conducted the present study to investigate the possible regulation of pdcd4 protein levels by mature miR-21. Materials and Methods: Forty pairs of NSCLC fresh-frozen tissues and their corresponding noncancerous tissues were analyzed for the expression of mature miR-21 using quantitative real-time RT-PCR, as previously described (Markou et al., 2008). In parallel, PDCD4 protein levels were evaluated by immunohistochemistry. Deparaffinized sections cut from paraffin-embedded tissue samples were stained with a specific anti-PDCD4 antibody (1:100 dilution) (Ozaki et al., 2006) using HRP DAB kit (DAKO) for the detection. The tumor types and stages were determined according to the WHO classification. All samples were analyzed histologically to access the amount of tumor component (at least 70% of tumor cells) and the quality of material. Results: Among the 40 NSCLC tissue specimens studied, suppresion of miR-21, in respect to their adjacent non-neoplastic tissues, was detected in 24 samples (60 %). In 15 out of these 24 patients (62.5%), we observed that the supression of miR-21 was accompanied by increase of PDCD4 protein levels. Mature miR-21 was overexpressed in 16 out of 40 patients (40%), and in 8 out of these 16 patients (50%) we detected reduced PDCD4 protein levels. Totally, in 23 out of 40 samples (57.5%), the altered miR-21 expression levels correlated with changed PDCD4 protein levels. Conclusion: Our data indicate for the first time that PDCD4 protein expression levels are regulated by miR-21 in non small cell lung cancer tissues. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2075.
SAFETY AND EFFICACY OF SUBCUTANEOUS IMPLANTABLE-CARDIOVERTER DEFIBRILLATOR IMPLANTATION: A SINGLE CENTER EXPERIENCE
Authors: Eduard Koman, Ashwani Gupta, Faiz Subzposh, Ankur Tiwari, John Fontaine, Slawomir Kusmirek, Steven Kutalek, Heath Saltzman
Journal: Journal of the American College of Cardiology (2015)
"User-Friendly" Cancer Statistics Review Features New Format
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article “User-Friendly” Cancer Statistics Review Features New Format Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Pages 1470–1471, https://doi.org/10.1093/jnci/84.19.1470 Published: 07 October 1992
DISECCIÓN SUBMUCOSA ENDOSCÓPICA EN NEOPLASIAS COLORRECTALES REALIZADAS POR EXPERTOS JAPONESES FUERA DE SU MEDIO
Authors: C Ordieres Díaz, A Parra-Blanco, T Uraoka, Y Saito, T Matsuda, T Nakajima, P Zaballa, MA Palacio, R Fernández, J Herrero, L Rodrigo
Journal: Endoscopy (2013)

Introducción: La disección submucosa (DSE) es una técnica muy popular en Japón para el tratamiento de neoplasias colorrectales precoces. En occidente se practica anecdóticamente, debido a su dificultad y la falta de programas de entrenamiento. Objetivo: Evaluar los resultados de las DSE colorrectales realizadas por expertos japoneses en programas de entrenamiento en occidente. Material y Método: Entre diciembre de 2009 y noviembre de 2011, tres expertos endoscopistas japoneses realizaron DSE en 17 pacientes en el Hospital Central de Asturias (Oviedo), en una experiencia formativa para los endoscopistas locales. Cada experto decidió el material de disección empleado. Las variables relacionadas con la lesión, la técnica y sus complicaciones y resultados fueron recogidas y posteriormente analizadas. Resultados: Hubo 7 lesiones de extensión lateral tipo granular (1 homogénea y 6 mixtas), 6 no granulares, 1 pólipo sésil y 3 recurrencias tras mucosectomía. El 59% se localizaban en el recto. El diámetro medio fue 38,7 ± 21,8 mm. El Dual knife fue el bisturí principal en el 76% de los casos y 3 se realizaron mediante disección híbrida (corte circunferencial + asa). El área media de los especímenes fue 11,3 ± 11,7 cm2. El tiempo de disección fue 97,3 ± 63,5 minutos con una velocidad media de 0,093 ± 0,083 cm2/minuto. La resección en bloque y curativa se consiguió en el 70,6% y 82,4% de los casos respectivamente. Un caso no fue posible técnicamente y preciso cirugía, al igual que otros 2 por recurrencias en el seguimiento. Hubo 3(17,6%) microperforaciones resueltas mediante colocación de hemoclips, y 2 (11,7%) hemorragias diferidas autolimitadas. Conclusiones: Fuera de su medio los expertos consiguieron resultados similares a los por ellos publicados en términos de resección curativa (superior al 80%) y aunque la tasa de perforaciones fue más elevada no implicó un peor curso clínico. En ausencia de DSE la mayoría de estos pacientes hubiesen sido tratados quirúrgicamente.
SAT0140 Recommendations for Investigating and Managing Comorbidity in Rheumatoid Arthritis: Table 1
Authors: E. Loza, C. Lajas, J.L. Andreu, A. Balsa, I. Gonzalez-Alvaro, O. Illera, J.A. Jover, I. Mateo, J. Orte, J. Rivera, J.M. Rodríguez Heredia, F. Romero, J.A. Martínez Lόpez, A.M. Ortiz, E. Toledano, V. Villaverde, L. Carmona, S. Castañeda
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> To develop evidence-based recommendations for the detection and management of comorbidity in rheumatoid arthritis (RA) in daily practice. <h3>Methods</h3> We used a modified RAND/UCLA methodology and systematic review. Discussion groups established recommendations, which were prioritized, refined, and graded in a large group of users by a 2-round Delphi survey. <h3>Results</h3> The first 9/21 recommendations with agreement (A), and level of evidence (LE) are listed in Table 1. <h3>Conclusions</h3> We established recommendations that cover what, how, when and by whom to investigate and manage comorbidity in RA. Additional materials, such as tables and checklists, will facilitate their implementation. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3089
Barrier Methods of Contraception
Journal: JAMA (1987)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
CPRE EN PACIENTES CON ANATOMÍA POSTQUIRURGICA: INDICACIONES, TÉCNICAS Y RESULTADOS
Authors: G González, R Sánchez-Ocaña, F Santos, V Busto, I Peñas, H Núñez, P Díez, P Gil, C De La Serna, M Pérez-Miranda
Journal: Endoscopy (2014)

Introducción: La alteración postquirúrgica de la anatomía del tracto digestivo (APQA) se asocia con obstrucción biliar. Enteroscopia, laparoscopia y abordajes percutáneos o USE-guiados (DBUSE) no siempre logran drenaje endoscópico de vía biliar.
President Signs NIH Appropriations Bill
Authors: M. C. Knipmeyer
Journal: JNCI Journal of the National Cancer Institute (1988)

Journal Article President Signs NIH Appropriations Bill Get access Mary C. Knipmeyer, Ph.D. Mary C. Knipmeyer, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 80, Issue 16, 19 October 1988, Pages 1276–1277, https://doi.org/10.1093/jnci/80.16.1276 Published: 19 October 1988
Abstract LB-140: An innovative approach for profiling of histone modification marks and gene expression across a panel of oncogenes and tumor suppressor genes in multiple cancer cell lines
Authors: Jiaqiang Huang, George J. Quellhorst, Xiujing Gu, Yan Xiang, Xiao Zeng, Kathy Boon
Journal: Cancer Research (2010)

Abstract Objectives: Histone modification marks and gene expression profiling on multiple human oncogenes and tumor suppressor genes to study the correlation between epigenetic modifications and gene expression in cancer cells derived from different tissue/cell types. Methodology: Chromatin Immunoprecipitation (ChIP) was performed on the isolated chromatin samples from various cancer cell lines (MCF7, A549, HepG2, HCT116, PC3 and HeLa) using antibodies against H3K4me2, H3K4me3, H3Ac, H3K27me3, H3K9me3, H4K20me3, and RNA Pol II. Each resulting ChIP DNA fraction was analyzed with a ChIP Real-Time PCR Array consisting of specific PCR primers targeting the downstream region of the transcription start site (within + 1Kb). For this study 84 oncogenes &amp; tumor suppressor genes were measured simultaneously along with control gene regions characteristic for each histone modification. Real-time RT-PCR Arrays were also employed to analyze the mRNA levels for all 84 genes in the same 6 cancer cell lines. These results allow analysis to correlate specific histone marks with the transcript levels. Results: The data indicate a much more complex correlation between modified histone marks and gene expression across different cancer cell lines. The results provide insights into the complex epigenetic regulation in cancer cells. The combination of ChIP-qPCR Arrays (histone modifications) and RT-qPCR Arrays to study multiple oncogenes and tumor suppressor genes simultaneously in various cancer samples should prove a valuable and fast approach in the assessment of the correlation between epigenetic regulation and clinical characteristics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-140.
Tc-99m Tetrofosmin Myocardial Perfusion Imaging Before and Six Months After Percutaneous Transluminal Coronary Angioplasty
Authors: P Georgoulias, N Demakopoulos, A Kontos, P Xaplanteris, K Thomadakis, G Mortzos, N Karkavitsas
Journal: Clinical Nuclear Medicine (1998)

The role of Tc-99m tetrofosmin single-photon emission tomography (SPECT) in the evaluation of myocardial perfusion before and 6 months after successful percutaneous transluminal coronary angioplasty (PTCA) was assessed in 41 consecutive patients (32 men and 9 women). Twenty-five patients had one-vessel disease, 14 had two-vessel disease, and 2 had three-vessel disease. Thirty-six patients had dilation of one vessel and five patients dilation of two stenosed vessels, with a total of 46 dilated vessels. All patients underwent coronary angiography both before PTCA and 6 months after revascularization. Restenosis was angiographically demonstrated in 16 (39%) patients and 16 (34.8%) vessels. Tc-99m tetrofosmin myocardial SPECT was 81.3% sensitive and 88% specific for the detection of restenosis in the group of patients with a positive predictive value of 81.3% and a negative predictive value of 88%. Sensitivity, specificity, positive predictive value, and negative predictive value were 81.3%, 90%, 76.5%, and 89.7%, respectively, for restenosis detection in specific vessels. It was concluded that most patients who underwent successful PTCA (34 of 41, or 82.9%) had significant (P < 0.001) improvement in their scan image 6 months after the angioplasty, and that Tc-99m tetrofosmin myocardial SPECT is an excellent tool to follow these patients because it can detect restenosis accurately and noninvasively.
OP0117 HDL-C and HBA1C predict the development of inflammatory polyarthritis: Results from the european prospective investigation of cancer (norfolk) and the norfolk arthritis register (EPIC-2-NOAR study)
Authors: T. Gati, C. Morgan, R.N. Luben, M. Lahiri, S.M. Verstappen, D.K. Bunn, M. Lunt, D.P. Symmons, N.J. Wareham, K.-T. Khaw, I.N. Bruce
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid Arthritis (RA) is associated with accelerated atherosclerosis and inflammation associated with RA may increase the propensity to develop dyslipidaemia and insulin resistance. In established RA, HDL-C (HDL) and ApoA-1 are negatively correlated with disease activity and insulin resistance is increased in RA patients. A few studies have suggested that lipid and glucose handling may be impaired prior to the onset of RA with Apo-B and triglyceride levels being found to be higher and HDL levels lower in those individuals who later develop inflammatory polyarthritis (IP). <h3>Objectives</h3> To investigate the association between lipid levels, diabetes and glycated haemoglobin on future risk of IP. <h3>Methods</h3> In the European Prospective Investigation of Cancer in Norfolk (EPIC-Norfolk) cohort, all participants completed a questionnaire at baseline and provided a non-fasting blood sample for routine lipid analysis. In subsets, additional biomarkers were measured including HbA1c, Apo-A1 and ApoB. Individuals with incident IP were identified by linkage with the Norfolk Arthritis Register (NOAR), a primary-care based disease register with an overlapping catchment area. We assessed the association of HDL, Apo-A1, ApoB and HbA1c with future risk of IP using Cox proportional hazard models. Confounders included age, gender, smoking status, smoking intensity, self-reported diabetes (DM) and Body Mass Index (BMI) and were controlled for in the final analyses. <h3>Results</h3> 25,455 EPIC participants aged 40-79 years were followed for a median (IQR) of 14.2 (12.9, 15.3) years (342,916 person-years of follow-up). 184 developed incident IP (69.6% women). Univariately, HbA1c [HR=1.3 (95% CI: 1.09, 1.55) per 1% increase] was associated with an increased risk of IP, remaining significant after further adjustment for confounders [HR=1.24 (95% CI: 1.05, 1.47) per 1% increase]. Univariately, neither Apo-A1, Apo-B nor HDL levels predicted IP onset. When multiple biomarkers were included in a single multivariable model, both HDL and HbA1c were significantly associated with incident IP [HR 0.76 (95%CI: 0.57, 1.00) per 0.4mmol/l and 1.24 (95% CI: 1.05, 1.47) per 1% respectively]. <h3>Conclusions</h3> In a prospective population-based cohort study low HDL and high HbA1c were identified as being associated with subsequent IP development. Several anti-inflammatory properties of HDL may be of relevance to its potential protective role. Glycated haemoglobin reflects insulin resistance which can promote a pro-inflammatory state in an at-risk population. <h3>Disclosure of Interest</h3> None Declared
THU0127 In Early Rheumatoid Arthritis (RA) Patients Persistent Moderate Disease Activity During the First Year has a Worst 3 and 5 Year Outcome than those in Remission : Data from the Espoir Cohort
Authors: B. Combe, I. Logeart, M. Belkacemi, T. Schaeverbeke, J.-P. Daures, M. Dougados
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The Treat to Target and EULAR recommendations highlighted the need for achieving and maintaining remission in patients with early RA. We investigated if early RA patients with persistent moderate disease activity during the first year have in daily life a worst 3 to 5 year outcome than patients who achieved clinical remission. <h3>Methods</h3> The ESPOIR cohort included 813 patients with early arthritis in at least 2 joints of less than 6 months disease duration. They were treated according to standard of care. Within the 573 patients who had a 5 year follow-up, 93 % fulfilled the ACR/EULAR criteria for RA. This study compared patients who were in persistent (at both the month 6 and month 12 visits) DAS28 remission (group.1) versus those who were in persistent (at both the M6 and M12 visits) moderate disease activity (DAS28&gt;3.2 and ≤5.1)(group.2). The primary outcome measure was radiographic progression ((modified Total Sharp Score (mTSS)) at month 36. Secondary endpoints were clinical remission (DAS28, SDAI, ACR/EULAR), HAQ-DI, number of missed workdays at month 36 and 60. Fisher exact test was used to compare categorical variables and Kruskal-Wallis test for quantitative variables. Logistic regression analysis was performed to determine confounding factors of outcome. <h3>Results</h3> Baseline characteristics were not significantly different between groups. Patients with persistent moderate disease activity during the first year, had greater radiographic progression, higher HAQ disability and number of missed days and lower rate of remission than those who achieved persistent remission (table). <h3>Conclusions</h3> This study demonstrated that early RA patients with persistent moderate disease activity during the first year of the disease had a worst outcome than patients who achieved clinical remission. Moderate disease activity state had substantial impact on structure, function and health outcomes. Patients should benefit from more intensive therapeutic strategy. <h3>Disclosure of Interest</h3> B. Combe: None Declared, I. Logeart Employee of: Pfizer, M. Belkacemi: None Declared, T. Schaeverbeke: None Declared, J.-P. Daures: None Declared, M. Dougados: None Declared