tbuckley/cabot-search huggingface dataset:
Abstract P145: Successful Use of Telephone and Mail for Obtaining Usable Accelerometer Data from a National Cohort: The Experience of the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study
Authors: Virginia J Howard, J D Rhodes, Brent Hutto, Kristine R Hearld, Natalie Colabianchi, John E Vena, Vena Seshadri, Anh Le, Margaret Stewart, Steven N Blair, Steven P Hooker
Journal: Circulation (2013)

Background: Epidemiologic studies examining physical activity have used self-report or the preferred objective measurement devices of pedometers or accelerometers. NHANES 2003-2004 used remuneration, in-person and express mail methods to obtain accelerometer data from 7176 individuals with 4867 (68%) providing 4+ valid days of wear. Herein we describe the experience of another national epidemiologic study that used telephone and regular mail to obtain accelerometer data. Methods: This is an ancillary study to REGARDS, a national, population-based, longitudinal study of 30,239 blacks and whites, aged &gt; 45 years, enrolled January 2003-October 2007. Participants were recruited from communities across all 48 of the lower United States, and include residents of 1,855 of the 3,033 US counties. Baseline evaluations were conducted through computer-assisted telephone interview (CATI), self-administered questionnaires, and an in-home visit. Participants are followed by CATI every 6 months. Starting with the May 2009 follow-up calls, contingent on availability of an accelerometer, participants were asked about willingness to wear an accelerometer for 7 days. Device inventory was 1150. Accelerometer, instructions, and stamped addressed envelope for return were mailed to consenting participants. Postcard acknowledgement, reminders, and &lt; two calls were made to encourage compliance with wearing device and its return. Participants receive summary results but no financial compensation. Results: By August 23, 2012, 22 195 were asked in a CATI follow-up to participate; 52% initially consented, 17% deferred and will be recontacted, and 31% declined. Participation rates by race-sex groups were: WM 53%, WF 53%, BM 53%, BF 50%. Devices were shipped to 11,798 with a return rate of 92%; 935 are lost (outstanding &gt; 120 days). Of accelerometers used/analyzed to date (n=9,422), 7819 (83%) provided 4+ valid days of wear, 434 (4.6%) had fewer than 4 valid days of wear, and 1,169 (12.4%) had incomplete/missing log sheet or device malfunction. The consenting-shipment-wearing-tracking-return-processing- and cleaning cycle is about 7-9 weeks per device, suggesting that approximately 6-7 participants can be evaluated per available device per year. Conclusions: A high yield of usable accelerometer data can be obtained from a national cohort through mail and telephone methods.
Post-transplant lymphoproliferative disorder of the ileum diagnosed by double-balloon enteroscopy
Authors: Seiichi Tawara, Shinichiro Shinzaki, Tsutomu Nishida, Motohiko Kato, Satoshi Hiyama, Takahiro Inoue, Hideki Iijima, Masahiko Tsujii, Tetsuo Takehara
Journal: Endoscopy (2013)

Post-transplant lymphoproliferative disorder (PTLD) is a common life-threatening complication after solid-organ transplantation that is mostly related to Epstein–Barr virus (EBV) infection [1]. PTLD occurs in 6.2 % of lung transplants, 5.2 % of kidney and pancreas transplants, 2 % of heart transplants, and 1.4 % of liver transplants [2]. Although around 15 % of patients present as an emergency with intestinal perforation [3], there are only a few reports of cases in which PTLD lesions in the small intestine have been observed endoscopically. We report a case of PTLD involving the ileum that occurred 11 months after heart transplantation and was detected during double-balloon enteroscopy (DBE).
Case 25-2013
Authors: Aria F. Olumi, Donald S. Kaufman, Anthony Zietman, Mukesh G. Harisinghani, Chin-Lee Wu
Journal: New England Journal of Medicine (2013)

A 71-year-old man with gross hematuria and a mass in the bladder was seen in the cancer center. Six weeks earlier, painless hematuria had developed, with passage of clots. CT and cystoscopy showed a lobulated mass at the bladder neck. A diagnostic test was performed.
Scatter Radiation from Palladium-103 Prostate Seed Implants on Bone Scan
Authors: PAUL F. L. COLOMB, JAMES J. SHEEHAN, VICENTE J. CARIDE
Journal: Clinical Nuclear Medicine (2000)

A 65-year-old man with prostate cancer underwent a bone scan for evaluation of metastatic disease and left second and third metatarsal fractures using 15.89 mCi Tc-99m MDP. He was status post insertion of one hundred thirteen 0.97-mCi prostatic TheraSeed palladium-103 implants (110 mCi). Although 20 to 23 keV characteristic radiographs are the most significant in terms of treatment dose, higher-energy gamma emissions of low abundance (297 keV = 0.011%, 362 keV = 0.060%, 498 keV = 0.011%) are responsible for scatter seen in the pelvis on a Tc-99m MDP bone scan. Because the palladium-103 half-life is 16.97 days, this interference will persist for weeks after seed implantation.
Use of a cap in single-balloon enteroscopy-assisted endoscopic retrograde cholangiography
Authors: Arvind Trindade, Jose Mella, Eoin Slattery, Jonah Cohen, Jacob Dickstein, Sagar Garud, Ram Chuttani, Douglas Pleskow, Mandeep Sawhney, Tyler Berzin
Journal: Endoscopy (2014)

Cannulation of the native papilla in surgically altered anatomy is difficult in endoscopic retrograde cholangiography (ERC). There are limited data regarding the success of single-balloon enteroscopy-assisted ERC (SBE-ERC) in patients with a native papilla and Roux-en-Y gastric bypass. Use of a plastic cap may assist cannulation in these cases. The aim of the current study was to investigate the use of SBE-ERC with a cap (Cap-SBE-ERC) in patients with surgically altered anatomy referred for ERC.Patients with surgically altered anatomy (hepaticojejunostomy, gastric bypass surgery, and Whipple's surgery) who underwent Cap-SBE-ERC were identified from a prospectively maintained database. Outcomes were diagnostic and procedural success. Patients with a native papilla were compared with those with a biliary-enteric anastomosis.Among 56 patients with surgically altered anatomy, high rates of diagnostic and procedural success were observed (78.6 % and 71.4 %, respectively). High diagnostic and procedural success rates of 72.7 % and 65.9 %, respectively, were also observed for patients with Roux-en-Y gastric bypass anatomy with a native papilla (n = 44).High rates of diagnostic and procedural success were reported for SBE-ERC with the use of a cap, including a large subgroup of patients with Roux-en-Y gastric bypass and a native papilla.
Abstract 286: Development and evaluation of a molecular decoy against SLUG function in the breast cancer cells
Authors: Mukul K. Mittal, Gautam Chaudhuri
Journal: Cancer Research (2012)

Abstract SLUG, also known as SNAI2, is a member of the SNAI superfamily of zinc-finger transcriptional repressors. It is a C2H2-type zinc finger transcription factor that binds to E2-box motif (5′-CAGGTG-3′/5′-CACCTG-3′), and silences gene expression by chromatin remodeling. More than ninety genes are shown to bind tightly to SLUG as was revealed by ChIP-on-chip analysis, showing the large regulatory network involving SLUG. It is recently implicated as the major mediator of the master transcriptional regulator protein TWIST. SLUG represses several genes to directly contribute towards the metastatic transformation of several epithelial cancer cells. Specific inhibitor against SLUG is not known. We describe here the development and evaluation of a nuclease resistant double-stranded DNA decoy that specifically inhibit the repressor activity of SLUG in the human breast cancer cells. The decoy is designed from the VDR gene promoter which is repressed by SLUG. This decoy has two SLUG-binding E2-box sequences. EMSA analysis showed in vitro binding of SLUG to the wild-type decoy but not to the E2-box mutated decoy. In vitro pull down analysis also showed high affinity binding of SLUG to the decoy. Biotin-tagged wild-type decoy DNA could immunopull down SLUG but little SNAIL from the extracts from decoy-transfected cells. The decoy increased the mRNA and protein levels of several SLUG target genes in MDA-MB-231 cells. The decoy also alleviated the repressive activity of SLUG on the SLUG target gene promoters in MDA-MB-231 cells. Since SLUG overexpression is implicated in the drug-resistance and antiapoptosis development in breast cancer cells, the SLUG decoy we developed should be useful to combat breast cancer progression when used with classical anticancer drugs. Supported in parts by the DOD-CDMRP grants BC050641, BC086542 and BC103645 to GC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 286. doi:1538-7445.AM2012-286
Ruptured Cerebral Aneurysms Caused by Micro-Organisms
Authors: Margot R. Roach, C. G. Drake
Journal: New England Journal of Medicine (1965)

RUPTURE of a cerebral aneurysm caused by a mycotic organism is a rare cause of subarachnoid hemorrhage. Published descriptions are few and meager and do not emphasize the importance of making the clinical diagnosis. Bacterial endocarditis may be indolent and not recognized for long periods until the unheralded rupture of a cerebral aneurysm. Even then the diagnosis may not be suspected in the turmoil associated with a serious neurologic illness. However, the site and appearance of these aneurysms are usually quite different from the typical "berry" aneurysm, and this fact should lead to vigorous attempts to establish the presence of . . .
Valvular Heart Disease
Authors: Blase A. Carabello, Fred A. Crawford
Journal: New England Journal of Medicine (1997)

The past 15 years have brought a remarkable improvement in the clinical outcome of patients with valvular heart disease. It is impossible to attribute the change to any single advance in the field. However, it is likely that more effective noninvasive monitoring of ventricular function, improvement in prosthetic valves, advances in valve-reconstruction techniques, and the development of useful guidelines for choosing the proper timing of surgical intervention have all worked in concert to improve prognosis. Moreover, advances in minimally invasive surgical techniques may make valve procedures more easily tolerated by the patient.1 All valvular heart diseases place a hemodynamic burden . . .
SAT0068 The Ts-Index as Sign Of Central Sensitization in Women with Active Rheumatoid Arthritis: A Comparative Cross Sectional Study
Authors: N. Vladimirova, A. T. Christensen, A. Jespersen, E. M. Bartels, R. Christensen, H. Bliddal, B. Danneskiold-Samsøe
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Despite better disease control, RA patients still rate pain as a major burden. That pain in some cases persists without signs of inflammation of the joints may indicate, that central pain sensitization could play a major role in the generation of chronic pain in some RA patients (1). Pain assessment is part of several tools used to evaluate RA disease activity e.g. DAS28 score. When applying DAS28, RA patients scoring high on tender joint count and global health may be classified to have active RA, despite no signs of inflammation (2). Central sensitization may also in part explain the significant portion of RA patients not responding to biologics treatment. Computerized Pneumatic Cuff Pressure Algometry (CPA) is a method for quantitative measurements of pain reactions and indications of central sensitization (3). Knowledge of contributing pain mechanisms in RA may be crucial, since interventions aimed at decreasing the inflammatory processes may not be sufficient in all patients. <h3>Objectives</h3> To assess the degree of peripheral and central sensitization in women with active RA compared to healthy controls. <h3>Methods</h3> 38 women with active RA (DAS28&gt;2,6) and 38 healthy controls were included in the study. CPA measurements were carried out on the dominant arm and leg. Following variables were determined: Pain Detection Threshold (PDT), Pain Tolerance Threshold (PTT), and Pain Tolerance Limit (PTL). Following this, during 10 minutes constant pressure stimulation at intensity relative to the individual pain threshold, the pain intensity was continuously recorded using an electronic Visual Analogue Scale (VAS). From this the degree of temporal summation (TS) was estimated (10 min CPA test at 50% of PTT-PDT). An index was calculated: <i>TS-index = log((VAS<sub>end</sub>/VAS<sub>max</sub>)*(10/T<sub>stim</sub>)*VAS<sub>end</sub>) (5).</i> <h3>Results</h3> Women with active RA have a lower pain threshold and pain tolerance than healthy controls. The mean TS-index in RA patients was 0.95 (95%CI: 0.86 to 1.04) and 0.81 (95%CI: 0.74 to 0.89)in healthy controls. Mean Difference was 0.14 (95%CI: 0.02 to 0.26; p = 0.022). <h3>Conclusions</h3> In active RA patients the TS index as measured by cuff algometry was on average increased, indicating signs of central pain sensitization. This type of pain may be of importance when considering treatment strategies. <h3>References</h3> Lee et al. Arthritis Res Ther 2011,13:R83. Leeb BF, Rheumatology (Oxford).2004; 43(12):1504-7. Graven-Nielsen, Arthritis Rheum2012; 64(9):2907-16. Jespersen A, Pain 2007; 131(1-2):57-62. <h3>Disclosure of Interest</h3> None Declared
Abstract P2-10-28: The Prognostic Index, KiGE, Combining Proliferation, Histological Grade and Estrogen Receptor Status Challenges Gene Profiling – A Study in 1,854 Chemo-Naïve Women with N0/N1 Primary Breast Cancer.
Authors: C Strand, M Bak, S Borgquist, G Chebil, A-K Falck, M-L Fjällskog, D Grabau, I Hedenfalk, K Jirström, M Klintman, P Malmtröm, H Olsson, L Rydén, O Stål, P-O Bendahl, M Fernö
Journal: Cancer Research (2012)

Abstract Purpose: The aim was to validate the prognostic value of a previously defined index (CAGE), combining proliferation (Cyclin A), histological grade, and estrogen receptor (ER) in different subsets of primary breast cancer patients. In the present study, Ki67 was included in the index (KiGE) instead of cyclin A, since it is the generally accepted proliferation marker in clinical routine. Patients and methods: 1,854 chemo-naive patients with primary breast cancer were included. The low KiGE group consisted of histological grade 1 cases and grade 2 cases which were ER-positive and had low Ki67 expression. High KiGE consisted of all other cases. Results: The KiGE index separated patients into groups with different prognosis. In multivariate analysis, KiGE was significantly associated with disease-free survival, when adjusted for age at diagnosis, tumor size and adjuvant endocrine treatment (hazard ratio: 3.5, 95% confidence interval: 2.6–4.7, P&amp;lt;0.0001). Conclusion: We have validated a prognostic index based on proliferation (Ki67), histological grade and ER, for identification of a low-risk group of patients with N0/N1 primary breast cancer. For this low-risk group, with a five-year distant disease-free survival of 92%, adjuvant chemotherapy will have limited effect and may be avoided. The KiGE index, based on clinically used factors, may challenge the more expensive gene expression profiles. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P2-10-28.
Complication Rate in General Surgical Cases
Authors: Rafael Sanchez-Ubeda, Edwin Fernand, Louis M. Rousselot
Journal: New England Journal of Medicine (1958)

THE prophylactic use of antibiotics in the hope of preventing disease or complications of disease has become almost routine in many phases of medical practice. This development, of course, has occurred only in the last fifteen years, since the discovery of penicillin, an effective antibiotic and one that is relatively innocuous in most cases, even when administered in large doses. Administration of antibiotics after surgery of all types has kept pace with this attempt at prophylaxis in other fields, rapidly developing from its use in contaminated cases, as in warfare, to its use without definite indications, after all types of . . .
Abstract 1006: Tumor associated mesenchymal stem cells protect ovarian cancer cells from hyperthermia through stromal cell derived factor-1 (SDF-1) secretion
Authors: Raphael Lis, Pejman Mirshahi, Fadoua Fares, Cyril Touboul, Rowaida Taha, Massoud Mirshahi, Arash Rafii
Journal: Cancer Research (2010)

Abstract Background: Hyperthermia therapy is a medical procedure where local body tissues are exposed to high temperatures ranging from 40oC to 43oC with the aim of killing microscopic tumor residue, being more susceptible to heat than normal cells. When combined with hyperthermia during cytoreductive surgeries, intraperitoneal chemotherapy was clinically proved to be more effective. While hyperthermia's cytotoxicity was tested on cancer cells, its effect on interactions between cancer cells and tumor stroma cells was minimally scrutinized. In this study, we investigate the effect of tumor associated mesenchymal stem cells, on inducing resistance of ovarian cancer cells (OCC) to hyperthermia. Methods: OCC viability was challenges by heat shock at 42 degrees, in simple or co-culture systems. Cell viability was determined using Calcein Violet AM by Fluorescence Activated Cell Sorting, FACS. The same experiment was replicated using a transwell system. Using the trogocytosis assay we measured the interaction between the different cell types. Multiparameter flow cytometry was used to study the relation between intercellular interaction and thermoresistance. Finally using inhibitors and blocking antibodies we were able to analyse the role of SDF1 pathway in thermoresistance. Results: At 42oC, an increase in viability of OCC, co-cultured with ‘MSC, was detected in comparison to cells cultured alone. The same result was attained using the transwell experiment. Antibody and siRNA for CXCR4 reversed the heat resistant effect of MSC cells on OCC. More interestingly we were able to demonstrate an increased expression of CXCR4 in cancer cells co-cultured with the MSC, and increased thermoresistance in the subset of cancer cells with more interaction (as measured by oncologic trogocytosis). Conclusions: This study proved that contact and non contact-based cell to cell interactions between MSC cells and OCC help ovarian cancer cells resist hyperthermia. Within these interactions, MSC-secreted SDF-1 could be the major inducer of heat resistance. Combining monoclonal antibody against CXCR4 with hyperthermic intraperitoneal chemotherapy could eliminate the protective effect of tumor associated mesenchymal stem cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1006.
Abstract 5174: Characterization of glycolipid ligands for E-selectin
Authors: Jocelyn Marshall, Courtney Abram, S. Matthew Wood, Leonardo Nimrichter, Monica M. Burdick
Journal: Cancer Research (2010)

Abstract The prevention, treatment, and curing of cancer are three of the most researched and highly anticipated areas of modern medicine. One of the greatest barriers to making advances within these fields is the lack of understanding of the molecular mechanisms responsible for cancer metastasis. Head and neck cancer (HNC) is the fifth most diagnosed cancer in the United States, according to the American Cancer Society, and claims the lives of many of its victims because it is often not diagnosed until metastasis has already occurred. After the onset of metastasis, the five-year survival rate drops to below thirty-five percent. Therefore, the study of how metastasis occurs is essential to finding a treatment for HNC. It is believed that metastasis occurs when cancer cells break free from the primary tumor and travel through the blood stream, attaching themselves onto endothelium of blood vessel walls and in turn, forming secondary tumors in new organs. The cell adhesion mediated by glycolipids on cancer cells to E-selectin on vascular endothlelium may be a significant contributor to cancer metastasis. E-selectin plays a significant role in the first two steps of the adhesion cascade, tethering and rolling, which initiate the recruitment process. In our preliminary studies, it has been shown that HNC cells express glycolipids that can bind to E-selectin. Flow cytometry shows that HNC cells express sialofucosylated molecules that could act as E-selectin ligands, and flow chamber adhesion assays confirm that HNC cells bind to cytokine-stimulated endothelial cells in a wholly E-selectin-dependent manner. Enzyme treatment further reveals that sialofucosylated glycolipids are major adhesive ligand(s) for E-selectin. Through the use of specialized flow chambers mimicking physiological conditions, optical tweezers, gas chromatography-mass spectrometry, the mediators of these adhesive interactions can be studied in depth, leading to the discovery of characteristics of cancer glycolipids that promote adhesion. The purpose of this investigation is to gain further insight as to which specific glycolipids located on HNCcells are potent ligands for E-selectin binding. With increased understanding of selectin-ligand adhesion interactions, the identity and properties of molecules responsible for metastasis can be used to determine possible therapeutic methods. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 5174.
EFECTIVIDAD DE LAS PRÓTESIS AUTOEXPANDIBLES BIODEGRADABLES EN EL MANEJO DE LAS ESTENOSIS BENIGNAS DEL TRACTO DIGESTIVO REFRACTARIAS AL TRATAMIENTO CONVENCIONAL
Authors: I Fernández-Urién, FJ Jiménez, A Iriarte, JJ Vila, A Pueyo, J Eguaras, E Albéniz
Journal: Endoscopy (2014)

Introducción: Las estenosis benignas del tracto digestivo (TGI) son habitualmente tratadas mediante dilataciones neumáticas (DN) y/o prótesis metálicas autoexpandibles cubiertas (SEMS) aunque, en ocasiones, su efectividad es escasa.
DISPLASIA SOBRE ESÓFAGO DE BARRETT. EVOLUCIÓN EN NUESTRO MEDIO
Authors: PL Fernández Gil, D Hernández Amunarriz, P Iruzubieta Coz, MJ García García, S Llerena Santiago, J De La Peña García, Á Terán Lantarón, F Fernández Fernández, J Crespo García
Journal: Endoscopy (2013)

Introducción: El Esófago de Barrett (EB) constituye el principal factor de riesgo para desarrollar Adenocarcinoma Esofágico (ACE). Objetivo: Estudio prospectivo de pacientes controlados por EB en el periodo 2009 – 2012. Estudio retrospectivo de su evolución previa. Valoración de características epidemiológicas, desarrollo de displasia/adenocarcinoma y evolución. Material y Método: Se estudian 179 pacientes. Se incluyen 171 (77'8% varones). EB largo 38% y corto 62%. Mediana: 3 cm (1 – 20). Mediana debut EB: 54 años (23 – 84). Resultados: