tbuckley/cabot-search huggingface dataset:
Fludrocortisone for the Prevention of Vasovagal Syncope
Authors: Robert Sheldon, Satish R. Raj, M. Sarah Rose, Carlos A. Morillo, Andrew D. Krahn, Eduardo Medina, Mario Talajic, Teresa Kus, Colette M. Seifer, Malgorzata Lelonek, Thomas Klingenheben, Ratika Parkash, Debbie Ritchie, Maureen McRae, R.S. Sheldon, S.M. Rose, D.A. Ritchie, M. McCrae, C. Morillo, V.M. Malcolm, A.D. Krahn, B. Spindler, E. Medina, M. Talajic, T. Kus, A. Langlois, M. Lelonek, S. Raj, C. Seifer, M. Gardner, M. Romeo, P. Poirier, C. Simpson, H. Abdollah, J. Reynolds, P. Dorian, D. Birnie, M. Giuffre, D. Gilligan, D. Benditt, R.S. Sheldon, S.R. Raj, M.S. Rose, A. Krahn, C. Morillo, E. Medina
Journal: Journal of the American College of Cardiology (2016)
Surveillance Imaging in Patients with Diffuse Large B-Cell Lymphoma
Authors: Ayako Matsumura, Hideyuki Kuwabara, Kumiko Kishimoto, Eriko Fujii, Kazuho Miyashita, Hiroyuki Takahashi, Shiro Matsuura, Yuki Nakajima, Hirotaka Takasaki, Masatsugu Tanaka, Shin Fujisawa, Heiwa Kanamori, Motomura Shigeki, Naoto Tomita
Journal: Blood (2015)
Tophaceous Gout
Authors: D A Wuthrich, A L Lebowitz
Journal: New England Journal of Medicine (1995)

Figure 1. Deforming gouty arthritis is evident in a 39-year-old woman who has had anorexia nervosa since the age of 15. Attacks of acute arthritis began at the age of 23; crystals of monosodium urate monohydrate were found in the joints during those attacks. The multiple cutaneous nodules on the distal aspect of the index finger are tophaceous deposits of monosodium urate crystals. Tophi first appeared when the patient was 24.
Cross-reactivity to fish and chicken meat - a new clinical syndrome
Authors: A. Kuehn, F. Codreanu‐Morel, C. Lehners‐Weber, V. Doyen, S.‐A. Gomez‐André, F. Bienvenu, J. Fischer, N. Ballardini, M. van Hage, J.‐M. Perotin, S. Silcret‐Grieu, H. Chabane, F. Hentges, M. Ollert, C. Hilger, M. Morisset
Journal: Allergy (2016)

Fish is one of the most allergenic foods. While clinical cross-reactivity among different fishes is a widely accepted feature of fish allergy, associations with other food allergies are not well understood. This study aims at analyzing the relevance of clinical cross-reactivity between fish and chicken meat in patients with allergy to chicken meat without sensitization to hen's eggs.Patients with food allergy to fish and chicken meat (n = 29) or chicken meat only (n = 7) were recruited. IgE-reactive chicken proteins were identified (Edman, MS analysis) and quantified (ELISA). Allergens were used in IgE ELISA and skin testing.Chicken parvalbumin and two new allergens, aldolase and enolase, were identified at 12, 40, and 50 kDa, respectively. They were recognized by sIgE of 61%, 75%, and 83% of all patient sera which were in the majority of the cases positive for the fish homologues as well. Fish and chicken meat allergens were highly cross-reactive while high inhibition rates with fish or chicken allergens correlated with the patients' primary sensitization to fish or chicken. In cooked or roasted foods, enolase and aldolase were detectable in chicken breast while parvalbumin was detectable in chicken legs and wings.Fish and chicken meat are cross-reactive foods; both fish-allergic and chicken meat-allergic patients might be at risk of developing a food allergy to chicken meat or to fish, respectively. This clinical phenomenon is proposed to be termed 'fish-chicken syndrome' with cross-reactive allergens involved being parvalbumins, enolases, and aldolases.
116TiP MONALEESA-7: a phase III, randomized, double-blind, placebo-controlled study of ribociclib (LEE011) combined with standard first-line endocrine therapy (ET) for the treatment of premenopausal women with HR +, HER2– advanced breast cancer (aBC)
Authors: S.-A. Im, L. Chow, Z. Shao, D. Tripathy, A. Bardia, S. Hurvitz, N. Harbeck, M. Colleoni, F. Franke, C. Germa, G. Hughes, L. McLean, M. Horan, Y.-S. Lu
Journal: Annals of Oncology (2015)
PD3-2-2: Changing the natural history of advanced non-small cell lung cancer with gefitinib? A single-center experience in Korea
Authors: Hyo Song Kim, Myung-Ju Ahn, Sangcheol Lee, Hyun Jung Jun, Seong Yoon Yi, In Gyu Hwang, Ji Eun Uhm, Jin Seok Ahn, Won Ki Kang, Keunchil Park
Journal: Journal of Thoracic Oncology (2007)
RM-017 Systemic chemotherapy in advanced gastric carcinoma: a comparison of docetaxel, cisplatin and fluorouracil (DCF) versus cisplatin and fluorouracil (CF); versus epirubicin, cisplatin and fluorouracil (ECF) regimens in clinical setting, a retrospective study
Authors: P. Kumari, S. Beniwal, P. Khatri, A. Kapoor
Journal: Annals of Oncology (2016)
18F-NaF PET/CT Images of Cardiac Metastasis From Osteosarcoma
Authors: Yi-Hsien Chou, Kuan-Yin Ko, Mei-Fang Cheng, Wei-Wu Chen, Ruoh-Fang Yen
Journal: Clinical Nuclear Medicine (2016)

Osteosarcomas are aggressive with a high incidence of recurrence and metastasis. Cardiac osteosarcoma metastasis is rare. We described a 17-year-old boy who had right distal femoral osteosarcoma with lung metastases. During follow-up, right ventricular (RV) metastasis was noted and confirmed by histopathological examination of the surgical specimen. 18F-NaF PET/CT was then arranged 1 month after debulking surgery for residual tumor survey. The images showed intense 18F-NaF uptake at RV region, suggestive of residual cardiac metastases.
Enhancers reside in a unique epigenetic environment during early zebrafish development
Authors: Lucas J. T. Kaaij, Michal Mokry, Meng Zhou, Michael Musheev, Geert Geeven, Adrien S. J. Melquiond, António M. de Jesus Domingues, Wouter de Laat, Christof Niehrs, Andrew D. Smith, René F. Ketting
Journal: Genome biology (2016)

Enhancers, not promoters, are the most dynamic in their DNA methylation status throughout development and differentiation. Generally speaking, enhancers that are primed to or actually drive gene expression are characterized by relatively low levels of DNA methylation (hypo-methylation), while inactive enhancers display hyper-methylation of the underlying DNA. The direct functional significance of the DNA methylation state of enhancers is, however, unclear for most loci. In contrast to conventional epigenetic interactions at enhancers, we find that DNA methylation status and enhancer activity during early zebrafish development display very unusual correlation characteristics: hypo-methylation is a unique feature of primed enhancers whereas active enhancers are generally hyper-methylated. The hypo-methylated enhancers that we identify (hypo-enhancers) are enriched close to important transcription factors that act later in development. Interestingly, hypo-enhancers are de-methylated shortly before the midblastula transition and reside in a unique epigenetic environment. Finally, we demonstrate that hypo-enhancers do become active at later developmental stages and that they are physically associated with the transcriptional start site of target genes, irrespective of target gene activity. We demonstrate that early development in zebrafish embodies a time window characterized by non-canonical DNA methylation–enhancer relationships, including global DNA hypo-methylation of inactive enhancers and DNA hyper-methylation of active enhancers.
Rational Design of Biomolecular Templates for Synthesizing Multifunctional Noble Metal Nanoclusters toward Personalized Theranostic Applications
Authors: Yong Yu, Beverly Y. L. Mok, Xian Jun Loh, Yen Nee Tan
Journal: Advanced Healthcare Materials (2016)

Biomolecule‐templated or biotemplated metal nanoclusters (NCs) are ultrasmall (&lt;2 nm) metal (Au, Ag) particles stabilized by a certain type of biomolecular template (e.g., peptides, proteins, and DNA). Due to their unique physiochemical properties, biotemplated metal NCs have been widely used in sensing, imaging, delivery and therapy. The overwhelming applications in these individual areas imply the great promise of harnessing biotemplated metal NCs in more advanced biomedical aspects such as theranostics. Although applications of biotemplated metal NCs as theranostic agents are trending, the rational design of biomolecular templates suitable for the synthesis of multifunctional metal NCs for theranostics is comparatively underexplored. This progress report first identifies the essential attributes of biotemplated metal NCs for theranostics by reviewing the state‐of‐art applications in each of the four modalities of theranostics, namely sensing, imaging, delivery and therapy. To achieve high efficacy in these modalities, we elucidate the design principles underlying the use of biomolecules (proteins, peptides and nucleic acids) to control the NC size, emission color and surface chemistries for post‐functionalization of therapeutic moieties. We then propose a unified strategy to engineer biomolecular templates that combine all these modalities to produce multifunctional biotemplated metal NCs that can serve as the next‐generation personalized theranostic agents.
Can axillary node dissection be safely omitted in the elderly? A retrospective study on axillary management of early breast cancer in older women
Authors: Emanuela Esposito, Viviana Sollazzo, Rosa Di Micco, Maria Cervotti, Gaetano Luglio, Giacomo Benassai, Pasquale Mozzillo, Stefano Perrotta, Vincenzo Desiato, Bruno Amato, Pietro Forestieri, Gennaro Limite
Journal: International Journal of Surgery (2016)
Irradiation of Mouse Skin With Single Doses of Ultraviolet Light2
Authors: Harold F. Blum, Elmer G. Butler, Thomas H. Dailey, Jasper R. Daube, Richard C. Mawe, Gerald A. Soffen
Journal: JNCI Journal of the National Cancer Institute (1959)

Journal Article Irradiation of Mouse Skin With Single Doses of Ultraviolet Light Get access Harold F. Blum, Harold F. Blum Search for other works by this author on: Oxford Academic PubMed Google Scholar Elmer G. Butler, Elmer G. Butler Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas H. Dailey, Thomas H. Dailey Search for other works by this author on: Oxford Academic PubMed Google Scholar Jasper R. Daube, Jasper R. Daube Search for other works by this author on: Oxford Academic PubMed Google Scholar Richard C. Mawe, Richard C. Mawe Search for other works by this author on: Oxford Academic PubMed Google Scholar Gerald A. Soffen Gerald A. Soffen Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 22, Issue 5, May 1959, Pages 979–993, https://doi.org/10.1093/jnci/22.5.979 Published: 01 May 1959 Article history Received: 01 December 1958 Published: 01 May 1959
PD4-1-3: How to improve loco-regional control in stage IIIa-b NSCLC? Results of a three-armed randomized trial from the Swedish Lung Cancer Study Group
Authors: Jan Nyman, Gunnar Wagenius, Signe Friesland, Mihalj Seke, Christer Sederholm, Brita Lödén, Lars Thaning, Stefan Bergström, Andreas Hallqvist
Journal: Journal of Thoracic Oncology (2007)
Authors should not compare survival of responders and nonresponders without discussing the limitations of such a comparison.
Authors: M S Piver
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.8.1300 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3625250 Authors should not compare survival of responders and nonresponders without discussing the limitations of such a comparison. M S PiverxM S PiverSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.8.1300 First Page PDF © 1987 by American Society of Clinical Oncology
Case 29-1985
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, M.L. Jacobs, I.F. Palacios, R. Liberthson
Journal: New England Journal of Medicine (1985)

Presentation of CaseA 37-year-old man was admitted to the hospital because of increasing dyspnea and edema.A diagnosis of congenital heart disease was made at the age of six months, when a physician found mild cyanosis and a loud systolic murmur. Frequent respiratory tract infections occurred during infancy. He began to crawl at nine months and to walk at two years. He was often observed in a knee—chest position in his crib, and he squatted after exertion during his early years. An uncomplicated tonsillectomy was performed at three years of age. At the age of six years a surgical . . .
Quantitative Studies on the Multiplication of Neoplastic Cells &lt;italic&gt;In Vivo&lt;/italic&gt;. II. Growth Curves of Three Ascites Lymphomas&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: László Révész, George Klein
Journal: JNCI Journal of the National Cancer Institute (1954)

Quantitative Studies on the Multiplication of Neoplastic Cells In Vivo. II. Growth Curves of Three Ascites Lymphomas Get access László Révész, László Révész Wallenberg Laboratory, Institute for Cell Research and Genetics, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar George Klein George Klein Wallenberg Laboratory, Institute for Cell Research and Genetics, Karolinska Institutet, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 15, Issue 2, October 1954, Pages 253–273, https://doi.org/10.1093/jnci/15.2.253 Published: 01 October 1954 Article history Received: 06 April 1954 Published: 01 October 1954
Coevolution of URAT1 and Uricase during Primate Evolution: Implications for Serum Urate Homeostasis and Gout
Authors: Philip K. Tan, Jennifer E. Farrar, Eric A. Gaucher, Jeffrey N. Miner
Journal: Molecular Biology and Evolution (2016)

Uric acid is the highly insoluble end-product of purine metabolism in humans. Serum levels exceeding the solubility threshold can trigger formation of urate crystals resulting in gouty arthritis. Uric acid is primarily excreted through the kidneys with 90% reabsorbed back into the bloodstream through the uric acid transporter URAT1. This reabsorption process is essential for the high serum uric acid levels found in humans. We discovered that URAT1 proteins from humans and baboons have higher affinity for uric acid compared with transporters from rats and mice. This difference in transport kinetics of URAT1 orthologs, along with inability of modern apes to oxidize uric acid due to loss of the uricase enzyme, prompted us to ask whether these events occurred concomitantly during primate evolution. Ancestral URAT1 sequences were computationally inferred and ancient transporters were resurrected and assayed, revealing that affinity for uric acid was increased during the evolution of primates. This molecular fine-tuning occurred between the origins of simians and their diversification into New- and Old-World monkey and ape lineages. Remarkably, it was driven in large-part by only a few amino acid replacements within the transporter. This alteration in primate URAT1 coincided with changes in uricase that greatly diminished the enzymatic activity and took place 27–77 Ma. These results suggest that the modifications to URAT1 transporters were potentially adaptive and that maintaining more constant, high levels of serum uric acid may have provided an advantage to our primate ancestors.
The Hematopoietic Stem Cell Transplant Comorbidity Index (HCT-CI) Can Predict for Readmission Following Autologous Stem Cell Transplant for Lymphoma and Multiple Myeloma
Authors: Samantha M. Jaglowski, Craig C. Hofmeister, Patrick Elder, Sam Penza, Yvonne A Efebera, Don M. Benson, Steven M. Devine, Leslie A Andritsos
Journal: Blood (2012)
TP53 Mutations In Patients With High-Risk Acute Myeloid Leukemia Treated With Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Jan Moritz Middeke, Silvia Herold, Elke Rücker-Braun, Brigitte Mohr, Wolfgang E. Berdel, Martin Kaufmann, Kerstin Schäfer-Eckart, Claudia D. Baldus, Reingard Stuhlmann, Falk Heidenreich, Friedrich Stölzel, Christoph Röllig, Uwe Platzbecker, Gerhard Ehninger, Martin Bornhäuser, Christian Thiede, Johannes Schetelig
Journal: Blood (2013)
A Novel Method for Screening Anti-Angiogenic Compounds: The Chorionicallantoic Membrane (CAM)/Feather Bud (FB) Assay.
Authors: Haiming Chen, Cathy S Wang, Mingjie Li, Eric Sanchez, Jennifer Li, Ariana M Berenson, Jeffrey A Steinberg, Hang Chen, Jing Shen, Zhi-Wei Li, Benjamin Bonavida, James R. Berenson
Journal: Blood (2008)
Cancer risk is higher in years before and shortly after type 2 diabetes diagnosis, study shows
Authors: Susan Mayor
Journal: BMJ (2016)

People with type 2 diabetes have a considerably higher risk of a wide range of cancers in the decade before their diabetes is diagnosed and in the period shortly after diagnosis than those without diabetes, a large follow-up study has shown.1

Growing evidence shows an association between type 2 diabetes and an increased risk of several cancers, particularly around the time of diabetes diagnosis. This may be due to improved detection …
La surveillance du temps de retrait du coloscope augmente le taux de détection des adénomes et les performances de l’endoscopiste
Authors: G Lesur
Journal: Endoscopy (2016)

Plusieurs travaux montrent que le temps de retrait du coloscope augmente les performances de la coloscopie. Une durée minimale raisonnable semble être de 6 minutes. Le but de ce travail était de comparer le temps de retrait chez des opérateurs dont le temps de retrait était mesuré comparativement à ceux pour qui il n’était pas enregistré.
Advanced multimodal nanoparticles delay tumor progression with clinical radiation therapy
Authors: Alexandre Detappe, Sijumon Kunjachan, Lucie Sancey, Vincent Motto-Ros, Douglas Biancur, Pascal Drane, Romain Guieze, G. Mike Makrigiorgos, Olivier Tillement, Robert Langer, Ross Berbeco
Journal: Journal of Controlled Release (2016)
Mitoxantrone Improves the Outcome of Children with Central Nervous System (CNS) Involvement at First Relapse of Acute Lymphoblastic Leukemia (ALL)-Results of the International ALLR3 Study
Authors: Ashish Narayan Masurekar, Catriona Anne Parker, Satarupa Choudhuri, Carly Leighton, Jeremy Hancock, Rosemary Sutton, Anthony V. Moorman, Phil Ancliff, Mary Morgan, Nicholas Goulden, Nina Green, Tamas Revesz, Peter Hoogerbrugge, Philip Darbyshire, Sharon Love, Vaskar Saha
Journal: Blood (2010)
Characterizing responses to CFTR-modulating drugs using rectal organoids derived from subjects with cystic fibrosis
Authors: Johanna F. Dekkers, Gitte Berkers, Evelien Kruisselbrink, Annelotte Vonk, Hugo R. de Jonge, Hettie M. Janssens, Inez Bronsveld, Eduard A. van de Graaf, Edward E. S. Nieuwenhuis, Roderick H. J. Houwen, Frank P. Vleggaar, Johanna C. Escher, Yolanda B. de Rijke, Christof J. Majoor, Harry G. M. Heijerman, Karin M. de Winter–de Groot, Hans Clevers, Cornelis K. van der Ent, Jeffrey M. Beekman
Journal: Science Translational Medicine (2016)

Rectal organoids from subjects with cystic fibrosis can be used to assess responses to drugs that modulate CFTR.
Encainide
Authors: R L Woosley, A J Wood, D M Roden
Journal: New England Journal of Medicine (1988)

THE antiarrhythmic properties of quinidine and digitalis were recognized as early as the 19th century, but it was not until the recognition in the 1960s of the antiarrhythmic actions of drugs for local anesthesia, such as lidocaine and procaine, that a systematic search was begun for similar agents with better antiarrhythmic efficacy and less toxicity. In the early 1970s Dykstra et al.1 described the synthesis of a series of analogues of lysergic acid that had antiarrhythmic activity. The activity of one of these agents, MJ 9067, or encainide, was characterized in experimental models of arrhythmias by Byrne et al.2 In . . .
A comparison of the natural history of oxaliplatin- and paclitaxel-induced neuropathy (NCCTG N08C1, N08CB/Alliance).
Authors: Kathryn Jean Ruddy, Dierdre Pachman, Rui Qin, Drew K. Seisler, Ellen M. Lavoie Smith, Suneetha Puttabasavaiah, Paul J. Novotny, Lauren E. Ta, Andreas S. Beutler, Nina D. Wagner-Johnston, Nathan Staff, Axel Grothey, Shaker R. Dakhil, Charles L. Loprinzi
Journal: Journal of Clinical Oncology (2015)

9564 Background: We examined the similarities and differences of paclitaxel and oxaliplatin neuropathy symptoms. Methods: Acute and chronic neuropathy data were pooled from pts receiving 1) adjuvant oxaliplatin (FOLFOX) in protocol N08CB (346 pts) and 2) weekly paclitaxel or every 3 week paclitaxel/carboplatin in protocol N08C1 (179 pts). In both trials, pts completed daily questionnaires for several days after each chemotherapy dose (to evaluate acute neuropathy) and the EORTC CIPN20 tool before each chemotherapy dose and at 1, 3, 6, and 12 months post treatment (to assess chronic neuropathy). Results: The acute neuropathy symptoms from both drugs peaked on day 3, with acute symptoms experienced in cycle 1 predicting occurrence in the subsequent cycles. Paclitaxel-induced acute symptoms were similar in intensity in each cycle and largely resolved between cycles. Oxaliplatin-induced acute symptoms were about half as severe in the first cycle, as in later cycles, and did not resolve completely between cycles. For chronic neuropathy, both drugs caused a predominantly sensory neuropathy (numbness and tingling much more common than pain). Oxaliplatin-induced chronic neuropathy worsened after the completion of treatment (coasting phenomenon) and began to improve 3 months post-treatment. In contrast, paclitaxel-induced chronic neuropathy typically began improving immediately after chemotherapy cessation. During treatment, paclitaxel numbness/tingling symptoms were similar in hands and feet; with oxaliplatin, hands were affected more than feet. After treatment completion, hand symptoms improved faster than foot symptoms, for both drugs, so that foot symptoms were more problematic one year later. Both paclitaxel- and oxaliplatin-induced acute neurotoxicity appeared to predict the severity of chronic neuropathy (more prominently with oxaliplatin). Conclusions: Patients receiving paclitaxel or oxaliplatin should be counseled regarding these patterns of neuropathy symptoms and recovery. Understanding the similarities and differences between these neuropathy syndromes should provide insight into the underlying pathophysiology and help find preventative treatment approaches. Clinical trial information: N08C1/N08CB.
A memorable teacher: Asking the right questions
Authors: H. Saxton
Journal: BMJ (2001)

I was listening to the news during one of many times of tension in Israel. Most people spoke about “Hebron,” but some of the Israeli settlers said “Hevron.” It was like smelling a long forgotten odour. I was taken back to 1944 and to French lessons with Mr Hudson-Davies, a tall, rotund, bespectacled man whose passion for etymological connections often led him to stray outside the curriculum. I could see and hear him emphatically booming “P, B, V, and F are the same letter.”

I realised that this was …
Anthracycline-Fludarabine Containing Regimens with or without Rituximab in the Treatment of Advanced Follicular Lymphoma Patients.
Authors: Stefano Sacchi, Luigi Marcheselli, Samantha Pozzi, Alessia Bari, Stefano Luminari, Fiorella Ilariucci, Caterina Stelitano, Francesco Angrilli, Antonio Lazzaro, Luca Baldini, Mauro Spriano, Giuseppe Caparrotti, Maurizio Musso, Giovanni Quarta, Maura Brugiatelli
Journal: Blood (2008)