tbuckley/cabot-search huggingface dataset:
Case 29-1997
Authors: Samuel Singer, Andrew E. Rosenberg
Journal: New England Journal of Medicine (1997)

Presentation of CaseA 54-year-old woman was admitted to the hospital because of pain and swelling of the right leg.The patient was otherwise in good health except for non-insulin-dependent diabetes mellitus of five years' duration, which was regulated by diet alone. Five years before admission, an endometrioid carcinoma, stage IC, of the right fallopian tube was treated by abdominal hysterectomy with bilateral salpingo-oophorectomy, followed by the administration of cisplatin and cyclophosphamide. Four months before admission, gynecologic and vaginal cytologic examinations and the CA-125 level were normal.One week before admission, the patient awoke with pain in the right calf . . .
Effects of Live Type 1 Poliovirus Vaccine and Other Viruses on the Tuberculin Test
Authors: Sumner Berkovich, Saul Starr
Journal: New England Journal of Medicine (1966)

THE depressing effect of measles on tuberculin sensitivity and its possible adverse effect on the clinical course of tuberculosis has been recognized for years.1 More recently, similar changes in tuberculin reactivity have been observed during gamma-globulin-attenuated and vaccine measles as well as during chicken pox.2 3 4 5 The question arises how many other naturally occurring or vaccine virus infections alter the tuberculin reaction, and, if so, whether they can adversely affect the course of tuberculosis.To provide answers to this query, we introduced the widely used Sabin Type 1 poliovirus vaccine into a closely supervised ward of tuberculous children receiving specific antituberculous . . .
AB0947 Musculoskeletal surgery in early (below 3 years of disease onset) spondyloarthritis is reported predominantly by caucasian, male, psoriatic arthritis patients among patients with spondyloarthritis:
Authors: S. Intzes, D. Lunda-Ngandu, A. Georgiou, E. Roussou
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> To estimate surgical interventions taken place in patients of early Spondyloarthritis (SpA) and to assess whether there are differences according to SpA subgroups, gender and race. The type of intervention and the timing of interventions related to disease onset were also to be determined. <h3>Methods</h3> Patients with SpA were asked to fill in a validated questionnaire if they had any musculoskeletal surgery, the type of surgery and the time during the disese process they had it. <b>Results:</b> From a total 425 patients with SpA 50 patients (11.7%) reported having musculoskeletal surgery at any point during the disease process. The diagnoses of the total surgery cohort (n=50) were: USpA 21 (42%), PsA=20 (40%), AS: 6 (12%); enteropathic n=3. They were 30 Caucasian, 14 Asian, 5 Africans, 1 mixed race. The delay in diagnosis of the surgical group was 5.3 years (y) ± 6.9; mean disease duration (dd) 12y ± 3.11; ESR 14.5±15; CRP 10.1±16. BASDAI score 6.7±1.9, and BASFI score 6.1±2.5. A total of 62 musculoskeletal surgical procedures were reported from the 50 patients of total SpAs: 36 knees (including arthroscopy) 7 hips, 6 spinal, 6 hands – wrists (including carpal tunnel), 3 ankles, 2 feet, 1 elbow, 1 shoulder. A total of 96 patients had early SpA [(PsA=47.9%, USpA 28.2%, AS 12.5%, enteropathic 9.4% ReA 1%, Juvenile 1%) (mean dd was of 1.8 y ± 0.7 mean age of disease onset 42.6y ±14.4)] 73.6% were on some form of medication. [98.9% were on NSAIDs, 62.9% on pain killers, 13.6% on steroids, 8.6% on Soulphasalazine, 6.1% on methotrexate and 1.3% on Leflunomide. Musculoskeletal surgery reported by 9 of 94 patients (9.3%) (M:F=5:4). The effectiveness of the medication of the whole early group (on a 100 mm VAS) reported as (mean ± sd) 4.2 + 2.8, while the well being over the past week was 5.9±2.7 and over the past 6 months was 6.4±2.6. All patients but 1 had PsA. Seven out of 9 were Caucasian, 1 African and 1 mixed race. The procedures were knee arthroscopy in 4 of 9 patients; carpal tunnel decompression in 2 of 9; 1 in finger, 1 in foot and 1 total hip replacement. In 6 of 9 patients the procedures have taken place 2 years prior to systemic disease onset and referral to hospital while in 2 of 9 one year prior to hospital attendance and 1 of 9 patients 3 years prior to hospital referral. <h3>Conclusions</h3> The surgery cohort has more serious disease manifested by BASDAI and BASFI. Caucasian male patients with early PsA have surgery earlier in the disease process. Knee surgery is the commoner surgical procedure in the total group and 1 in 10 patients with early disease has some form of surgery prior to deciding hospital referral. <h3>Disclosure of Interest</h3> None Declared
THE SPHINGOSINE-1-PHOSPHATE RECEPTOR AGONIST FINGOLIMOD REDUCES ISCHEMIA-REPERFUSION INJURY BY DECREASING CARDIOMYOCYTE APOPTOSIS MEDIATED BY ACTIVATION OF THE RISK PATHWAY
Authors: Carlos G. Santos-Gallego, Belen Picatoste, Ida U Njerve, Torsten Vahl, Kiyotake Ishikawa, Roger Hajjar, Valentin Fuster, Juan Badimon
Journal: Journal of the American College of Cardiology (2015)
Bowel endometriosis mimicking gastrointestinal stromal tumor and diagnosed by endoscopic ultrasound
Authors: Rogerio Colaiacovo, Augusto Carbonari, Ricardo Ganc, Gustavo de Paulo, Angelo Ferrari
Journal: Endoscopy (2014)

A 51-year-old asymptomatic woman was referred for colorectal cancer screening. During colonoscopy, a rectosigmoid subepithelial lesion was found, measuring approximately 2 cm and covered by normal mucosa ([Fig. 1]). An endoscopic ultrasound (EUS) was performed to evaluate the lesion further. Radial and linear probes showed a hypoechoic lesion, measuring 22 × 9 mm, infiltrating the muscularis propria ([Fig. 2], [Fig. 3] and [Fig. 4]). EUS-guided fine-needle aspiration (EUS-FNA) of the lesion was performed using a 22-gauge needle ([Fig. 5]). Histopathological examination showed the presence of endometrial glands and stroma ([Fig. 6]).
Hillary Clinton Praises NIH Scientists, Urges Perseverance in Health Care Reform
Authors: N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Hillary Clinton Praises NIH Scientists, Urges Perseverance in Health Care Reform Get access Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 6, 16 March 1994, Pages 422–423, https://doi.org/10.1093/jnci/86.6.422 Published: 16 March 1994
AB1088 Clinical features and outcomes of septic sacroiliitis in tunisian individuals
Authors: A. Berriche, K. Ben Abdelghani, R. Abdelmalek, L. Souabni, B. Kilani, H. Tiouiri Ben Aissa, T. Ben Chaabane, L. Zakraoui
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> The aim of this study was to characterize the clinical, biological, imaging aspects and outcomes of infectious arthritis of sacroiliac joints in Tunisian individuals. <h3>Methods</h3> A retrospective bicentric study involving cases of infectious arthritis of sacroiliac joint admitted to hospital between January 2002 and December 2011. Diagnosis was based on clinical examination and image, bacteriological and histological tests. Clinical, laboratory and radiological data, causative microorganism, treatment and outcome was identified. <h3>Results</h3> We included 15 cases with septic sacro-iliitis; 9 males and 6 females. The mean age was 40,26 years (15 - 71 years). Six patients consume impasteurized milk and only one reported contact with family members known to have tuberculosis. The most frequent symptoms are fever (86,7%) and fessialgy (80%). Pain in the sacroiliac mobilization and lameness are noted in 93,3% and 66% of patients. Leucocitosis was present in 13,3% of patients; elevated ESR in 53,3% and elevated RCP in 40%. Plain radiographies of 7 patients showed lesions that would suggest sacroiliitis, CT had confirmed this diagnosis in 9 patients and magnetic resonances in 6 patients. The lesion was bilateral in one case, associated with spondylodiscitis in 3 cases, and with psoas abscess in 3 cases. The causative agent was isolated in 73,3% of patients, according to the haemocultures in 4 cases, sputum culture in one case, serology in 5 cases and nodes biopsy in one case. The etiology was brucellosis in 5 cases, tuberculosis in 4 cases and <i>Staphylococcus aureus</i> in 4 cases. The causative germ was not identified in 2 cases. Appropriate antibiotic therapy was effective for all the patients, none needed surgical treatment. None of the 15 patients showed evidence of a relapse of the lesion. <h3>Conclusions</h3> Infection of sacro-iliac joint is a rare condition. Prompt diagnosis and appropriate antibiotherapy results in excellent outcome in most cases. <h3>Disclosure of Interest</h3> None Declared
Abstract 1899: Validation of the Spitz lung cancer risk prediction model with the Dutch-Belgian randomized lung cancer screening trial (NELSON) cohort
Authors: Anthony M. D'Amelio, Eleonora Baecke, Margaret R. Spitz, Harry J. de Koning, Rob J. van Klaveren, Carol J. Etzel
Journal: Cancer Research (2011)

Abstract Background: Risk modeling has been shown to be important in detection and prevention of disease, and this is especially true for cancer research. One prominent lung cancer risk model is the Spitz Lung Cancer Risk Model, which was constructed from case-control data and incorporates clinical and epidemiologic variables (smoking status, family history and select co-morbidities). Although the Spitz model is validated using case-control data, the model has not been calibrated. Methods: We used data from 109 lung cancer patients and 4622 controls that were a subset of a large longitudinal cohort study, the Dutch-Belgian randomized lung cancer trial (NELSON). We estimated absolute lung cancer risks from the Spitz risk model to evaluate the model's calibration, discriminatory power and clinical utility. Results: With the 10 year absolute risk calculations, the Spitz model was well calibrated with NELSON data, with slightly weaker calibration for five year absolute risk calculations. The overall discriminatory power was 0.69 (95% CI = 0.64-0.74), with current smokers having higher discriminatory power (0.73, 95% CI = 0.67-0.79) compared to former smokers (0.61, 95% CI = 0.51-0.70). When examining clinical utility, it peaked at four lung cancer patients correctly identified by the model for every control incorrectly identified as a lung cancer patient. Conclusions: This is the first time the Spitz model has been evaluated for calibration, with very good results except for the lowest and highest risk individuals. The calibration results also confirmed the notion by Dr. Peter Bach's group that 10 year absolute risk models are better indicators of cancer risk than five year models. The clinical utility results are very similar to those calculated by the Spitz model with Harvard data that was published in the British Journal of Cancer recently. The Spitz model showed moderate discriminatory power, especially among current smokers. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1899. doi:10.1158/1538-7445.AM2011-1899
??OLONIC MOTILITY SCINTIGRAPHY: CORRELATION WITH ??ANOMETRIC STUDIES.
Authors: Pierre B. Lambert, Eduardo Morenosset, Georges Y. Baillet, Arnulfo S. Pleyto, William J. nape, Ismael G. Mena
Journal: Clinical Nuclear Medicine (1987)

Lambert, Pierre B.; Morenosset, Eduardo??; Baillet, Georges Y.; Pleyto, Arnulfo S.; nape, William J.??; Mena, Ismael G. Author Information
F-18 FDG PET Positive Hilar and Mediastinal Lymphadenopathy Mimicking Metastatic Disease in a Melanoma Patient Treated With Interferon-alpha-2b
Authors: Dimitrios Kalkanis, Alexandros Kalkanis, Osama Gomaa, Fabio M. Paes, George N. Sfakianakis
Journal: Clinical Nuclear Medicine (2011)

A 49-year-old man with a history of recurrent melanoma in the parotid was treated with parotidectomy, external beam radiation, and high-dose interferon-alpha-2b. Combined F-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG PET/CT) performed for restaging demonstrated multiple bilateral hilar and mediastinal hypermetabolic foci corresponding to hilar and mediastinal lymphadenopathy. Cytologic specimens obtained by bronchoscopy were negative for malignancy, revealing reactive lymph nodes. Subsequent FDG PET/CT showed regression of the findings. Awareness of possible interferon-associated reaction in melanoma patients who undergo FDG PET is important to avoid pitfalls in the interpretation.
Diabetes Patient Education Programs: Quality and Reimbursement
Authors: Madelyn L Wheeler, Elizabeth Warren-Boulton
Journal: Diabetes Care (1992)

To inform health-care providers and third-party carriers of the national quality assurance systems in place for diabetes education programs and the health professionals who provide education services and to indicate the need for consistent reimbursement of essential outpatient diabetes education services. The components of an independent quality assurance mechanism were examined and a survey was conducted to determine reimbursement coverage of ADA recognized programs. A national program to evaluate whether programs meet national standards is in place. Many ADA approved programs were reimbursed and official recognition helped in the process of attaining reimbursement. Insurance coverage decisions made by third-party carriers, however, were inconsistent and largely unpredictable. Outpatient education and follow-up for diabetes is an integral component of care. These services need to be more clearly defined to enable appropriate coding and coverage decisions to be made by third-party payors.
Abstract 171: Cell memory of a genotoxic insult is mediated by methyltransferases
Authors: Rebecca E. Rugo, James T. Mutamba, K. Naga Mohan, Tiffany Yee, J. Richard Chaillet, Joel S. Greenberger, Bevin P. Engelward
Journal: Cancer Research (2010)

Abstract Characterization of the direct effects of DNA damaging agents shows how DNA lesions lead to specific mutations. Yet, serum from Hiroshima survivors, Chernobyl liquidators, and radiotherapy patients can induce a clastogenic effect on naive cells, showing indirect induction of genomic instability that persists years after exposure. Such indirect effects are not restricted to ionizing radiation, as a chemical genotoxin induces a heritable and transmissible genomic instability phenotype. While such indirect induction of genomic instability is well described, the underlying mechanism has remained enigmatic. Here, we show that mouse embryonic stem (ES) cells exposed to γ-radiation remember the insult for weeks. Specifically, conditioned media from progeny of exposed cells can induce DNA damage and homologous recombination in naive cells. Notably, cells exposed to conditioned media also elicit a genome destabilizing effect on their neighbours, thus demonstrating transmission of genomic instability. Moreover, we show that the underlying basis for the memory of an insult is completely dependent on two of the major DNA cytosine methyltransferases (MTases), Dnmt1 and Dnmt3a. Targeted disruption of these genes completely eliminates transmission of genomic instability. Furthermore, transient inactivation of Dnmt1, using a tet-suppressible allele, clears the memory of the insult, thus protecting neighbouring cells from indirect induction of genomic instability. We have therefore shown that a single exposure can lead to long-term genome destabilizing effects that spread from cell to cell, and we provide a specific molecular mechanism for these persistent bystander effects. Collectively, our results impact current understanding of risks from toxin exposures and suggest specific mechanisms for suppressing genomic instability in people exposed to carcinogenic genotoxins. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 171.
Abstract 2179: Computational pharmacogenomics analysis of human cancer cell lines
Authors: Elena Edelman
Journal: Cancer Research (2010)

Abstract Purpose: The goal of this study is to use cell-based drug screening and genome-wide molecular information to identify fundamental genomic alterations useful for clinical applications. Experimental Approach: Molecular data has been collected in the form of high-throughput microarray-based assays measuring gene expression and copy number changes for 294 cell lines, as well as cell-based drug sensitivity measures for 110 drugs. A computational analysis approach is taken to integrate information from the large cancer cell line datasets to discover predictive biomarkers that can be used to better guide targeted cancer drugs. Cancer genes and gene networks that are vital in a cancer cell's sensitivity or resistance to these drugs are identified by first locating genomic regions of recurrent amplification and deletion across the entire cell line panel. These regions are further analyzed for copy number associations with marked drug sensitivity or resistance. Those regions with copy number differences between drug sensitive and resistant cell lines are then examined on the gene expression level for cancer gene deregulation. Results: 156 chromosomal regions of recurrent copy number alteration are identified across the cell line panel. 15 compounds are associated with differential copy number between sensitive and resistant cell lines in one or more of these regions for a total of 77 significant drug-region associations. Out of these 77 associations, 13 of the regions also include genes which are differentially expressed between the sensitive and resistant cell lines. Conclusions: Genes that are deleted in drug sensitive or drug resistant cell lines can act as biomarkers for drug sensitivity or resistance respectively. Similarly, genes amplified in drug sensitive cell lines can act as biomarkers for drug sensitivity. Genes amplified in drug resistant cell lines provide hypotheses for combination therapy, as we believe that the amplification that is seen only in the drug resistant cell lines is a driving factor causing the resistance to that drug. Using the drug along with pharmacological inhibition or experimental knockdown of the gene commonly amplified in the resistant cell lines is hypothesized to alter the cell lines from a drug resistant to a drug sensitive state. Novel combination therapies for use in given drug resistant cell lines harboring specific amplifications are currently being validated. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2179.
Cytotoxic T-Cell Immunity to Influenza
Authors: Andrew J. McMichael, Frances M. Gotch, Gary R. Noble, Paul A. S. Beare
Journal: New England Journal of Medicine (1983)

In a study designed to determine whether cytotoxic T lymphocytes contribute to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with live unattenuated influenza A/Munich/1/79 virus. Over the next seven days clinical observations were made, and the amount of virus shed was measured. The protective effects of preinfection serum antibody and of cytotoxic T-cell immunity against influenza A virus were assessed for each participant. All subjects with demonstrable T-cell responses cleared virus effectively. This response was observed in volunteers in all age groups, including those born after 1956, who did not have specific antibody and hence had probably not been exposed to this subtype of influenza A virus before. Cytotoxic T cells show cross-reactivity in their recognition of the different subtypes of influenza A virus, in contrast to the antibody response that is specific for each virus subtype. We conclude that cytotoxic T cells play a part in recovery from influenza virus infection.
THU0373 Retrospective Analysis of the Safety of Zoledronic Acid in Patients with Osteoporosis in the Course of Connective Tissue Diseases Compared to Patients with Postmenopausal Osteoporosis.
Authors: B. Jaszczyk, J. Trefler, M. Wisłowska
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Causes of osteoporosis in patients with connective tissue diseases (CTD) are more complex than in patients with postmenopausal osteoporosis (PO). None of the studies published so far examined the safety and efficacy of once-yearly intravenous zoledronic acid 5 mg administration in CTD patients. <h3>Objectives</h3> The aim of the study was to assess safety of the zoledronic acid administration in patients with osteoporosis in the course of CTD and compare it to patients with PO. <h3>Methods</h3> We investigated 160 patients with osteoporosis including those without CTD or PO who received in total 278 infusions of intravenous zoledronic acid 5 mg in the period 2010-2012. Two subgroups of patients were identified: 47 with osteoporosis in the course of CTD including 33 with rheumatoid arthritis and 91 with PO. All patients included into the study fulfilled the osteoporosis densitometric criteria according to WHO and had contraindications to the use of oral bisphosphonates. The primary endpoint was the number of complications observed in CTD patients after the zoledronic acid administration compared to the number of complications registered in patients with PO. <h3>Results</h3> Both PO and CTD patients groups showed no statistically significant differences in terms of the mean age (73 vs. 70,66 years), T score result before the first administration of zoledronic acid (-2,91 vs. -2,81) and mean number of osteoporotic fractures (1,8 vs. 1,69). The number of complications in patients with CTD was significantly higher (14,89% - 7 patients) than in patients with PO (3,29% - 3 patients) (p&lt;0,03). Furthermore in patients with PO the only observed type of adverse reaction were flu-like symptoms whereas in patients with osteoporosis associated with CTD also more severe complications were registered such as the renal function impairment (3 cases) and osteonecrosis of the jaw (1 case). <h3>Conclusions</h3> The safety and efficacy of a single 5 mg intravenous infusion of zoledronic acid should be further investigated as our retrospective analysis suggests that in patients with CTD treated with zoledronic acid the number of complications is significantly higher and they are more severe as compared to patients with PO. <h3>Disclosure of Interest</h3> None Declared
HISTORICAL NOTES
Authors: EVANGELOS PAPATHOMOPOULOS, WILLIAM F. KNOFF
Journal: American Journal of Psychiatry (1964)

Kahlbaum's original concept of catatonia as probablè brain disease in part manifested by "overstretching" or "overtensing" of the musculature was reflected in his choice of the term catatonia for the syndrome. Subsequent investigations of the curious muscular phenomena in catatonia have followed physiological and psychological lines. At present, it appears that catatonic muscular symptoms might be primarily viewed as psychological (communicative) in nature.