tbuckley/cabot-search huggingface dataset:
PTU-265 Long term survival after the liver first approach for synchronous colorectal liver metastases: a single centre propensity score case-matched analysis
Authors: FK Welsh, K Chandrakumaran, TG John, AB Cresswell, M Rees
Journal: Gut (2015)

<h3>Introduction</h3> Liver resection prior to resection of the primary cancer is a novel strategy advocated for selected patients presenting with synchronous colorectal liver metastases (sCRLM). This study measured outcomes in patients with sCRLM, following a liver-first (LFA) or classical approach (CA) and used a validated propensity score, the Basingstoke Predictive Index (BPI), to determine differences in survival between case-matched groups. <h3>Method</h3> Clinical, pathologic, and complete follow-up (median 34 months) data were prospectively recorded from 582 consecutive patients undergoing hepatic resection for sCRLM at a single centre (2004–2014). 98 patients had a LFA and 467 had a CA to treatment. 17 patients who had a simultaneous bowel and liver resection were excluded. Cumulative disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) were calculated using Kaplan Meier analysis. <h3>Results</h3> The LFA group had significantly more patients with rectal cancer (44.9% vs. 27.8%, p = 0.001) or poorly differentiated primaries (17.3% vs. 9%, p = 0.001), had a higher median [interquartile range (IQR)] number of sCRLM [3 (1–20) versus 2 (0–19), p = 0.0007] and size (in millimetres) of sCRLM [17 (3–24), versus 15 (2–29), p = 0.023], compared to the CA patients. Moreover, the median (IQR) preoperative BPI was significantly higher in the LFA group [8.5 (5–10)], versus CA group [8.0 (4–9), p = 0.03]. 73.5% of LFA patients had neoadjuvant chemotherapy, compared to 59.7% in the CA group (p = 0.01). Whilst more LFA patients had a major liver resection (69.4% vs. 56.5%, p = 0.018), there was no difference in Clavien-Dindo grade 3/4 complications (10.2% vs. 7.1%, p = 0.392), median (IQR) length of stay in days [6 (4–9) versus 6 (5–8), p = 0.835] or 30-day mortality [2% vs. 0.2%, p = 0.079] compared to the CA group. The 5 year DFS was 22.8% in the LFA group, significantly lower than the CA group (45.6%, p = 0.001). However there was no difference in 5 year CSS (53.8% vs. 51.1%, p = 0.379) or OS between groups (43.7% vs. 49.6%, p = 0.305). When patients were matched for pre-operative BPI, there was no statistical difference in either 5 year DFS (37% vs. 41.2%, p = 0.083), CSS (53.2% vs. 51.2%, p = 0.616) or OS (44.9% vs. 49.8%, p = 0.846) between groups. <h3>Conclusion</h3> In our unit, patients with sCRLM selected for a LFA were a group with more oncologically advanced disease and a poorer prognosis. These patients had a significantly inferior cumulative DFS compared to patients selected for a CA. However, there was no significant difference in cumulative DFS when prognostic variables were matched according to preoperative BPI. These data provide further evidence to support a LFA in selected patients with sCRLM. <h3>Disclosure of interest</h3> None Declared.
Interspersed Advertisements
Authors: B C Dundon
Journal: JAMA (1971)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Tracheobronchomegaly
Authors: Gabriele Casso, Patrick Schoettker
Journal: New England Journal of Medicine (2016)

An 84-year-old man with severe aortic-valve stenosis was admitted for transapical aortic-valve implantation. He had a history of chronic bronchitis and recurrent respiratory infections. After endotracheal intubation and tube-cuff inflation, a severe peritubal air leak was identified.
Dépistage de la dysplasie biliaire au cours de la cholangite sclérosante primitive par CPRE et brossage biliaire: facteurs de risques néoplasiques
Authors: J. Branche
Journal: Endoscopy (2016)

La cholangite sclérosante primitive (CSP) est une affection biliaire inflammatoire chronique, majoritairement associée à une MICI, qui se complique dans environ 10 % des cas de cholangiocarcinome. Les facteurs de risque de dégénérescence sont mal connus et le diagnostic est souvent difficile, parfois tardif.
Assessing families in their own homes
Authors: P Steinglass
Journal: American Journal of Psychiatry (1980)

Assessment of the family in its own home provides important information about the family's style of regulating its internal environment. The author presents data from a study of families in which one of the spouses was alcoholic. These families were observed at home on nine occasions over a six-month period; the technique used, the Home Observation Assessment Method, measured dimensions of family behavior associated with routines of daily living. Dimensions of home behavior were highly correlated with traditional clinical measures of psychiatric symptomatology, severity of alcoholism, and family boundaries.
Host Determinants of Response to Antimicrobial Agents
Authors: Louis Weinstein, A. Condon Dalton
Journal: New England Journal of Medicine (1968)

Indigenous Microbial Flora Superinfection, a phenomenon characterized by the appearance of both microbiologic and clinical evidence of a new infection superimposed on the one being treated, is a common complication (about 2.5 per cent) of the use of all antibiotics. The factors that predispose to its development are very young and old age, pulmonary disease other than tuberculosis and the use of "broad-spectrum" or combined drugs.133 The organisms responsible for the new disease are, for the most part, members of the normal microbial flora that inhabits various areas of the body, especially the upper respiratory and intestinal tracts. In some . . .
Soundings: Basic science
Authors: George Dunea
Journal: BMJ (1999)

In this second part I have selected more answers given by junior high, high school, and college students in their exams (24 April, p 1153), but this time in the basic sciences.

Science, after all, is the order of the day; for without it how can we ever make any progress as we enter the next millennium?

How indeed can we even hope to spend our summer vacations on the moon, find pen friends on Mars, clone our grandfathers, or examine our patients by moving a cursor on a mouse pad?

It is science that will enable our young people to grow up strong and straight, live well and die well, eat well and email well, move up in the world and get better jobs than flipping hamburgers at $5.50 an hour.

Physics: “H2O is hot water, and CO2 is cold water.” “Nitrogen is not found in Ireland because it is not found in a free state.” “Water is composed of two gins: oxygin, which is pure gin, and hydrogin, which is gin and water.” “When you smell an odourless gas, it is probably carbon monoxide.”

Chemistry: “A supersaturated solution is one that holds more than it can hold.” “To collect fumes of sulphur, hold a deacon over a flame in a test tube.”

Geology: “The tides are a fight between earth and the moon. All water tends towards the moon because there is no water on the moon and nature abhors a vacuum.” “The moon is a planet like the earth, only it is even deader.”

Botany: “Mushrooms always grow in damp places and so look like umbrellas.” “Rhubarb is a kind of celery gone bloodshot.” “The pistol of a flower is its only protection against insects.” “Dew is formed on leaves when the sun shines down on them and makes them sweat.”

Definitions: “Equator—a managerie of lions running round the Earth through Africa.” “Planet—a body of earth surrounded by sky.” “Germinate—to become a naturalised German.” “Litre—a nest of young puppies.” “Momentum—what you give a person when they are going away.” “Vacuum—a large empty space where the pope lives.”

Other: “A magnet is something you find crawling over a dead cat.” “A fossil is an extinct animal. The older it is, the more extinct it is.” And, “To keep milk from turning sour, keep it in the cow.”
Growth hormone catecholamines in affective disease
Authors: D L Garver, G N Pandey, H Dekirmenjian, F Deleon-Jones
Journal: American Journal of Psychiatry (1975)

The authors studied growth hormone (GH) release after insulin-induced hypoglycemia (HI) in relation to urinary MHPG, the major metabolite of central norepinephrine. There was a significant linear correlation of urinary MHPG levels and GH peaks after HI in unipolar depressed patients and in manic patients; however, GH peaks in manic patients shifted downward on the GH axis in comparison to the unipolar depressive patients. The authors suggest that such shifts in the GH response may occur as a result of abnormalities of other neurotransmitter systems also known to facilitate GH release.
Mammalian Chromosomes &lt;italic&gt;In Vitro&lt;/italic&gt;. XIII. Cyclic and Directional Changes of Population Structure&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: T. C. Hsu
Journal: JNCI Journal of the National Cancer Institute (1960)

Cells of strain L-P59 of the mouse multiply to at least twice as many cells as those of two L-P59 derivatives, strains Amy and Barbara. In mixed populations with an initially equal proportion of either L-P59 and Amy or L-P59 and Barbara cells, L-P59 cells completely dominated within 4 to 8 weeks. A marker chromosome, known as “D,” was one of the most conspicuous elements in cells of L-P59. Cells contained 0, 1, 2, and 3 D chromosomes. In young cultures, mitotic cells with 0 or 1 D chromosome dominated the population, whereas in aged cultures those with 2 or 3 D chromosomes dominated it. When cultures of L-P59 were subcultured twice a week, the populations shifted to a lower D chromosome content (average D chromosome per cell below unity). Conversely, when cultures were subcultured once in 2 weeks without intervening feeding, the population shifted to a higher D chromosome content (average D chromosome per cell above 1.5). Also, when a young culture was suddenly treated with aged medium, the D chromosome content also increased among the mitotic cells. The results demonstrate that cell populations are composed of numerous genomes which are harmoniously balanced. Under one environmental condition, one or several genomes become the stem cells, but other genomes are able to replace them whenever conditions change.
Multiple Pregnancy
Authors: Kurt Benirschke, Chung K. Kim
Journal: New England Journal of Medicine (1973)

Everybody is, or should be, interested in twins.H. H. NewmanTWINNING occurs often enough — approximately 1:80 pregnancies — to constitute an important biologic event. Because of the frequency with which obstetric and neonatal hazards accompany multiple pregnancy, it is recognized as having considerable medical importance. Although it has long been known that two classes of twins exist, so-called identical and fraternal twins, it was not until Sir Francis Galton, the cousin of Charles Darwin, proposed twins as model for the understanding of disease that twin research became an active field.1 Galton suggested that by comparison of various findings . . .
Distilling complexity to advance cardiac tissue engineering
Authors: Brenda M. Ogle, Nenad Bursac, Ibrahim Domian, Ngan F. Huang, Philippe Menasché, Charles E. Murry, Beth Pruitt, Milica Radisic, Joseph C. Wu, Sean M. Wu, Jianyi Zhang, Wolfram-Hubertus Zimmermann, Gordana Vunjak-Novakovic
Journal: Science Translational Medicine (2016)

Five central challenges must be met to advance the current state of the art in modeling heart disease and realizing heart repair.
HIV infection and AIDS in the European Union and European Economic Area, 2010
Authors: G Likatavicius, M J van de Laar
Journal: Eurosurveillance (2011)

In 2010, a total of 27,116 newly diagnosed HIV infections were reported by 28 countries of the European Union and European Economic Area (EU/EEA), with evidence of continuing transmission and no clear signs of decline. The predominant mode of transmission and increasing trend of HIV in the EU/EEA was due to sex between men. An increase in AIDS diagnoses in several countries and a high proportion of late presenters suggest delayed access to treatment and care.
Central Nervous System Complications After Allogeneic Hematopoietic Cell Transplantation – Treatment Related Morbidity, Toxicity, Graft Versus Host Disease Or New Autoimmunity
Authors: Christoph Simon, Nora Mirza, Wolfgang A. Bethge, Wichard Vogel, Christoph Faul, Hans-Georg Rammensee, Lothar Kanz, Sebastian P. Haen
Journal: Blood (2013)
Low influenza vaccination coverage in asthmatic children in France in 2006-7
Authors: F Rance, C Chave, J De Blic, A Deschildre, L Donato, JC Dubus, M Fayon, A Labbé, M Le Bourgeois, C Llerena, G Le Manach, I Pin, C Santos, C Thumerelle, M Aubert, C Weil-Olivier
Journal: Eurosurveillance (2008)

Binary file ES_Abstracts_Final_ECDC.txt matches
Induction of Liver Tumors in Rats Fed <italic>p</italic>-Dimethylaminobenzene-1-Azo-2-Naphthalene
Authors: Ambadas S. Mulay, Charles C. Congdon
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Induction of Liver Tumors in Rats Fed p-Dimethylaminobenzene-1-Azo-2-Naphthalene Get access Ambadas S. Mulay, Ambadas S. Mulay National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles C. Congdon Charles C. Congdon National Cancer Institute,2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 571–583, https://doi.org/10.1093/jnci/14.3.571 Published: 01 December 1953 Article history Received: 12 June 1953 Published: 01 December 1953
Abstract 15: Global RNA Splicing Regulation in Cardiac Maturation
Authors: Chen Gao, Shuxun Ren, Jae-Hyung Lee, Yun-Hua Esther Hsiao, Xinshu (Grace) Xiao, Jau-nian Chen, Atsushi Nakano, Joseph C Wu, Yibin Wang
Journal: Circulation Research (2015)

Background: The complexity of transcriptome and proteome is contributed by alternative splicing of mRNA. Altered mRNA splicing is implicated in both development and disease. However, the change of alternative mRNA splicing during cardiomyocytes maturation is unknown, and the regulatory mechanisms remain unexplored. Methods and Results: Using deep RNA-Sequencing, we identified global alternative splicing changes associated with both cardiac development and pathological remodeling in mouse heart. Further, we identified a highly conserved splicing regulator-RBFox1 to be significantly induced during zebrafish, mouse and human cardiac maturation. RBFox1 expression was also detected in cardiomyocytes derived from both mouse and human embryonic stem cells but at much lower levels comparing to adult heart. In zebrafish embryos, inactivation of RBFox1 caused cardiomyocyte maturation defects. Expression of RBFox1 in cultured neonatal cardiomyocytes was sufficient to promote maturation by reducing fetal marker gene expression while increasing calcium handling gene expression including RyR and promoting sarcomere organization. Deep RNA-Sequencing analysis showed that RBFox1 expression promoted alternative splicing in genes involved in calcium cycling, blood vessel development and muscle contraction. Finally, we identified a highly conserved mutually exclusive alternative splicing event of transcription factor MEF2 to be a direct downstream target of RBFox1. Expression of individual MEF2 splicing variants led to different cardiac developmental phenotypes in zebrafish, indicating their different transcriptional activities. Conclusion: Our study provided the first comprehensive analysis of mRNA splicing regulation in heart during post-natal development and heart failure, and identified RBFox1 as a key regulator for alternative RNA splicing during cardiomyocytes maturation. Further exploration of RBFox1 mediated RNA splicing regulation in heart may yield novel insight to the underlying mechanisms of cardiac maturation and new approach to improve cell based therapy for heart diseases.
FRI0283 Long-Term Adherence to Treatment in a Fracture Liaison Service Coordinated by Rheumatologist and Nurse: Table 1
Authors: A. Naranjo, S. Ojeda-Bruno, A. Bilbao-Cantarero, S. Rodríguez-Moreno, B.V. Díaz-González, J.C. Quevedo Abeledo, C. Rodríguez-Lozano
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Although management of osteoporosis (OP) is cost-effective in high-risk patients, less than 20% of patients with fragility fracture receive antiresorptive drugs and more than 50% stop treatment after a year. <h3>Objectives</h3> The main objective was to evaluate the long-term adherence to treatment of a program for secondary prevention of OP fractures <h3>Methods</h3> Patients &gt;50 years with fragility fracture were enrolled in a prospective observational study. The program consisted of: 1) training of primary care physicians, 2) recruitment of patients from emergency unit, 3) baseline visit: questionnaire by the nurse, bone densitometry and patient education; 4) clinical report referral to primary care or rheumatology (those with multiple fractures or requiring special therapy); and 5) follow-up through a phone survey and checking the prescriptions in electronic records. The outcome of the program was analysed 2 years after implementation, including 1) percentage of attendees/eligible; 2) percentage of attendees who start treatment with bisphosphonates; 3) percentage of patients who retain treatment after 6, 12,18 and 24 months; and 4) factors associated to adherence. <h3>Results</h3> After 2 years of implementation, the program detected 1674 patients, of whom 759 finally entered the program (57% of eligible). After 3 months, 52% of the patients (82% of those with prescribed antiresorptive) in the program started treatment. Factors associated with starting treatment at 3 months were female sex (85% vs 71%; p=0.01), previous treatment with antiresorptive (91% vs 80%; p=0.02), hip fracture (89% vs forearm 75%; p=0.007) and being attended by a rheumatologist (89% vs primary care 69%; p&lt;0.001). Adherence to treatment at 6, 12 and 18 months among those who had prescribed treatment with bisphosphonates was 73%, 71% and 73% respectively. We only have data of 50 patients with 24 months follow-up, 72% of them were on treatment. Factors associated with adherence at 12 months were female sex and previous treatment with antiresorptive (Table). The causes of withdrawal of treatment at 12 months in 83 phoned patients were as follows: 25 patients do not agree to take treatment, 24 patients by unknown reasons, 18 stopped or not started by primary care doctor, 8 because gastrointestinal complaints, 5 because of being taking many drugs, and 3 because others diseases. <h3>Conclusions</h3> In Spain, a program designed to prevent secondary fragility fractures based on the collaboration between primary care and rheumatology is effective in terms of recruitment of patients and adherence to treatment in the long-term. <h3>Acknowledgements</h3> Proyecto nacional del Ministerio de Ciencia e Innovaciόn. Instituto de Salud Carlos III: PI11/01429 <h3>Disclosure of Interest</h3> None declared
Comment: the role of psychiatry in medicine
Authors: H Leigh
Journal: American Journal of Psychiatry (1982)

Psychiatry shares with the rest of medicine all basic goals, assumptions, and approaches as well as many techniques. Any apparent "differences in approach" between psychiatry and general medicine arise from a confusion between the essentials and the specialized techniques and procedures developed in psychiatry. The educational task of psychiatry--to integrate relevant knowledge and skills from the behavioral sciences with the biological sciences and to operationalize a comprehensive approach to patient care--can be accomplished by the general psychiatrist through consultation and collaborative care of patients.
Olfactory receptor for prostaglandin F2α mediates male fish courtship behavior
Authors: Yoichi Yabuki, Tetsuya Koide, Nobuhiko Miyasaka, Noriko Wakisaka, Miwa Masuda, Masamichi Ohkura, Junichi Nakai, Kyoshiro Tsuge, Soken Tsuchiya, Yukihiko Sugimoto, Yoshihiro Yoshihara
Journal: Nature Neuroscience (2016)
Know, treat, prevent – HIV testing, a key strategy in the prevention and control of the HIV/AIDS epidemic
Authors: M Sprenger
Journal: Eurosurveillance (2010)

Preview this article: Know, treat, prevent – HIV testing, a key strategy in the prevention and control of the HIV/AIDS epidemic, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/48/art19736-en-1.gif
On Caring for the Patient with Cancer
Authors: J. Englebert Dunphy
Journal: New England Journal of Medicine (1976)

An Annual Oration or Discourse has been delivered by distinguished members of the Massachusetts Medical Society in almost uninterrupted sequence since the year 1804. For the 195th Anniversary Meeting, I am the 166th Orator, and the second to be selected from my home town of Northampton, the first being Joseph Henshaw Flint, who spoke "On the Prophylactic Management of Infants and Early Childhood" in 1826. Under these circumstances, I am impelled not only to express my heartfelt gratitude to the membership for the honor of delivering this Oration, but also to acknowledge my debt to the many members of this . . .