tbuckley/cabot-search huggingface dataset:
“People do not read enough or very wisely”—Ross MacCardle
Authors: J. R. M. Innes
Journal: JNCI Journal of the National Cancer Institute (1965)

Journal Article “People do not read enough or very wisely”—Ross MacCardle Get access J. R. M. Innes J. R. M. Innes Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 35, Issue 1, July 1965, Pages VI–VII, https://doi.org/10.1093/jnci/35.1.VI Published: 01 July 1965
FRI0101 Objective Evaluation of Sleep and Inflammation Markers in Women with Rheumatoid Arthritis: A Cross-Sectional Study
Authors: A.H. Kayo, M.T.D.M. Mello, L. Oliveira, J. Gávea, R. Giorgi, V.F.M. Trevisani
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Sleep deprivation contributes to many abnormalities: immune system deficiencies, pain, fatigue and impaired quality of life. About 54-70% of patients with rheumatoid arthritis (RA) have sleep complaints and this can influence the control of disease activity [1,2]. <h3>Objectives</h3> Primary objective was to evaluate the influence of the level of RA activity on objective variables measured by by polysomnography (PSG). Secondary objective was to evaluate the correlation of the quality of sleep, evaluated subjectively by the Pittsburgh Sleep Quality Index (PSQI), with common complaints such as pain, depression and functional capacity. <h3>Methods</h3> Women with a diagnosis of RA according to the ACR/EULAR 2010 criteria and sleep quality complaints (PSQI &gt;5) were submitted to whole-night PSG in a sleep laboratory [3]. Disease Activity Score (DAS28) was also used in the evaluation of RA and the women were divided in two groups: DAS28 &lt;3.2 (group A) and the other with DAS28 ≥3.2 (group B). Pain (by the visual analogue scale, VAS), depression (evaluated using the Beck Depression Inventory, BDI), and functional capacity (by the Timed Up &amp; Go Test, TUG). The generalized linear model (GLM) test was used to compare the variables between groups. Pearson correlation was calculated. Statistical analysis considered α ≤0.05. <h3>Results</h3> In the study period, 43 women were evaluated. Group A (DAS28: 2.23±0.62 mm/h) had 16 participants and was aged 54.75±7.05 years. Group B (DAS28: 4.38±0.84 mm/h) had 27 women aged 54.37±7.17 years. Both groups had a low sleep efficiency (78.76±8.47 and 78.14±13.33; p=0.87) and superficial sleep (&gt; %N1): 10.09±4.32 versus 9.58±4.63 (p=0.72). Both had also a short period of REM sleep (16.41±7.13 versus 16.98±5.65; p=0.77). Group B had a higher wake after onset sleep (A: 67.79±33.49 versus B: 74.17±50.02; p=0.65) and higher arousal index (A: 13.21±7.04 events/h versus B: 17.75±29.16 events/h; p=0.54) and higher apnea-hypopnea index (A: 4.61±5.45 events/hour e B: 11.27±12.82 events/hour; p=0.05). A significant correlation was found between PSQI and pain (r =0.43; p=0.004) and a positive correlation with TUG (r =0.33; p=0.03) e BDI results (r =0.60; p=0.001). <h3>Conclusions</h3> Women with higher DAS28 tend to have a higher frequency of sleep disorders, impaired quality of life, function and more depression, which clearly demonstrates the extent of the impairment caused by RA. <h3>References</h3> Iber C, Ancoli-Israel S, Chesson A, Quan S. for the American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications. 1st ed. Westchester, IL: American Academy of Sleep Medicine; 2007 <h3>Disclosure of Interest</h3> None declared
The Quantitative Measurement of Depression and Anxiety in Male Alcoholics
Authors: John E. Hamm, Leslie F. Major, Gerald L. Brown
Journal: American Journal of Psychiatry (1979)

Depression and anxiety have been reported to be commonly associated with alcoholism. Most attempts to clarify this relationship have suffered from a patient selection bias in that only those alcoholics who sought treatment were studied. The authors performed quantitative measurements of depression and anxiety in a group of 48 men referred for treatment solely on the basis of excessive drinking. The prevalence of depression and anxiety as measured by both the Zung and Hamilton scales was lower than that shown in previous studies. The results of this study indicate that problems in young, healthy male alcoholics.
Virus of Avian Myeloblastosis. XV. Structural Loci of Virus Synthesis and Adenosinetriphosphatase Activity by Electron and Light Microscopy of Myeloblasts from Tissue Culture&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: M. N. Haddad, David Weinstein, R. A. Bonar, G. S. Beaudreau, Caroline Becker, Dorothy Beard, J. W. Beard
Journal: JNCI Journal of the National Cancer Institute (1960)

Exploratory experiments have been made to effect a correlation between specific structures seen with the light microscope in primitive cells occurring in virus-induced avian myeloblastosis and structures demonstrable in earlier studies in electron micrographs of thin sections of these cells. In thin sections of the cells, growing under suitable conditions in tissue culture, the specific structures, viroplasts, appeared as osmophilic bodies containing virus particles, and were interpreted previously as the sites of virus synthesis. Phase-contrast microscopy revealed intracellular bodies of comparable size, number, and distribution, which have been judged to be representative of the viroplasts identified in thin sections. Evidence has been advanced to indicate that the structures in question exhibit a strong adenosinetriphosphatase reaction as demonstrated by means of the Wachstein-Meisel staining procedure. Normal myeloblasts from bone marrow, as well as those from the circulating blood of chickens with myeloblastosis, showed little or no evidence of the intracellular enzyme, a finding compatible with the infrequent occurrence of viroplasts in myeloblasts taken directly from the circulating blood. Erythroblasts from birds with erythroblastosis showed no evidence of staining. The granules of myelocytes from bone marrow also stained heavily for the enzyme. The possible origin of viroplasts from a common progenitor of mitochondria and granules to account for the presence of adenosinetriphosphatase in the myeloblastosis virus particle is discussed.
Breast implant associated anaplastic large cell lymphoma
Authors: Reem Dina Jarjis, Steen Henrik Matzen
Journal: BMJ (2019)

Breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL) is a rare entity. Due to the lack of awareness of BIA-ALCL, patients with prior history of breast implants who present with non-specific implant-related complications might experience a delay in diagnosis and appropriate treatment of this distinct condition. There are still no evidence-based guidelines on how this condition should be diagnosed, treated or followed because of the rarity of available data. We review current literature in order to raise awareness and discuss management options of this unique clinical entity.
Excess of infections due to a multi-drug sensitive Salmonella enterica serotype Typhimurium in France in June 2008
Authors: F Grandesso, N Jourdan-da Silva, S Le Hello, S Roussel, S Rasson, C Rousseau, K Wyndels, I Robemanpianina, I Bourdeau, C Peyron, R M Géhin, M B Moyano, C Vogeleisen
Journal: Eurosurveillance (2008)

An unusually high number of cases of Salmonella Typhimurium was reported in France in June 2008. In the course of epidemiological investigations 112 cases were ascertained, of whom 75 were interviewed. Subtyping by PFGE and MLVA identified a strain named ""majority profile"". Subtyping results were available for 45 interviewed cases, 30 of whom (majority below 15 years of age) were found to be infected with the majority profile strain. Evidence suggested the occurrence of an outbreak due to a monoclonal S. Typhimurium strain with the single PFGE profile XTYM-50. Cases with identical PFGE profile were also detected in Switzerland but no link with outbreaks occurring in the same period in Denmark and in the Netherlands was found. Contamination of a product distributed nationally was suggested as the cause of the outbreak but investigations did not reveal any specific food source.
AB1156 Involvement of Patient Research Partners in Clinical Research: Recommendations Developed by Omeract
Authors: P. Cheung, M. De Wit, C.O. Bingham, J. Kirwan, A. Leong, L. March, P. Montie, M. Scholte-Voshaar, L. Gossec
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Patient participation in research is increasing; however, practical guidelines to enhance this participation are lacking. Specifically within the Outcome Measures in Rheumatology (OMERACT) organization, although patients have participated in OMERACT meetings since 2002, consensus about the procedures for involving patients in working groups has not been formalized. Recommendations would therefore be useful, both within OMERACT and for clinical research projects at both national and international levels. <h3>Objectives</h3> To develop a set of recommendations regarding patient research partner (PRP) involvement in research projects. <h3>Methods</h3> (i) systematic literature review on recommendations/guidelines of PRP involvement in research; (ii) structured consensus process based on a draft set of recommendations developed by a working group of 4 clinicians and 4 patient research partners, with then involvement of multiple stakeholders during the OMERACT 2014 meeting in May 2014 (iii) endorsement of recommendations by OMERACT. <h3>Results</h3> (i) In the 18 articles included in the literature review [1], there was general agreement on the broad concepts for recommendations covering PRP involvement in research although they were heterogeneous in detail. Most considered PRP involvement in all phases of research with early engagement, training and support important, but details on the content were scarce. (ii) From this review, a structured consensus process led by the working group resulted in three over-arching principles and 8 recommendations which were developed, discussed, and refined at OMERACT 2014. The guiding principles were endorsed during the OMERACT plenary session by 99% of participants and subsequently by the OMERACT steering committee. <h3>Conclusions</h3> Recommendations to formalize and enhance PRP involvement in OMERACT research projects have been developed and endorsed. These reinforce the importance of patient participation throughout the research process as integral members and will enable a research agenda to evaluate their implementation and impact on outcome development. These recommendations can potentially be applied for PRP in clinical research settings other than OMERACT. <h3>References</h3> Cheung P, de Wit M, Gossec L. Ann Rheum Dis 2014;73(Suppl2):619-620. <h3>Disclosure of Interest</h3> None declared
SAT0267 Is the Widely-Used Score in Axial Spondyloarthritis, Basdai (Bath Ankylosing Spondylitis Diseases Activity Index), Influenced by Patients' Optimism? a Cross-Sectional Study of 206 Patients
Authors: S. Fabre, A. Molto, S. Kreis, S. Dadoun, C. Rein, C. Hudry, B. Fautrel, E. Pertuiset, L. Gossec
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The Bath Ankylosing Spondylitis Diseases Activity Index (BASDAI) is widely used to assess disease activity in axial spondyloarthritis (axSpA) and is a criterion for initiating anti-TNF therapy. Psychological distress (anxiety/depression) may be related to BASDAI scores (1), which may be an issue when using the BASDAI to decide on treatment strategies. Do stable personality traits like dispositional optimism-a general positive mood or attitude towards the future-also influence BASDAI results? <h3>Objectives</h3> To determine if BASDAI scores are influenced by optimism in axSpA. <h3>Methods</h3> A cross-sectional study was performed in two tertiary care hospitals and one office-based practice in France (2). Patients had definite axSpA according to the rheumatologist. Auto-questionnaires included the BASDAI and optimism, evaluated through the French version of the Life Orientation Test-Revised (LOT-R) (3). The LOT-R consists of 10 questions:the score ranges from 0 (low optimism) to 24 (high optimism). Analyses included Spearman correlation and multivariate regression analyses to explain BASDAI based on optimism, adjusted on demographic variables and anxiety/depression, evaluated through the Hospital Anxiety and depression scale (HADS). <h3>Results</h3> 206 patients were included: mean age, 46.3 years, 49.0% were men. Mean disease duration was 15.5±10.8 yrs, mean BASDAI (0-10) was 3.8±2.0. Optimism was low to moderate: mean LOT-R score was 13.7±4.3. Optimism was significantly though slightly correlated to BASDAI scores: R=-0.15, p=0.04. However, in the multivariate analysis, there was no significant relationship between BASDAI and optimism. <h3>Conclusions</h3> Optimism was not associated to BASDAI scores in multivariate analyses. This result confirms that BASDAI is a valid tool, which can be interpreted independently of patients9 personality traits like optimism. This result is reassuring in view of the reports of a relationship between anxiety/depression and BASDAI. However, optimism is a stable personality trait through life whereas anxiety and depression are variable psychological states. More work is needed on the best ways to analyse SpA activity; in particular ASDAS should be further evaluated. <h3>References</h3> Brionez TF, et al. Psychological Correlates of Self-Reported Disease Activity in Ankylosing Spondylitis. J Rheumatol 2010; 37:829-34. Fabre S, et al. Do Patients with Axial Spondyloarthritis (AxSpA) Perform Enough Physical Activity? a Cross-Sectional Study of 207 Patients. Arthritis Rheum 2014, 66(suppl):S1125. Scheier MF et al. Distinguishing optimism from neuroticism (and trait anxiety, self-mastery, and self-esteem): A re-evaluation of the Life Orientation Test. J Pers Soc Psychol 1994, 67:1063-78. <h3>Disclosure of Interest</h3> None declared
Major depression in patients with social phobia
Authors: M B Stein, M E Tancer, C S Gelernter, B J Vittone, T W Uhde
Journal: American Journal of Psychiatry (1990)

The authors examined the longitudinal course of affective illness retrospectively in 63 patients with social phobia and 54 patients with panic disorder. Significantly fewer (35%) of the patients with social phobia than patients with panic disorder (63%) had experienced at least one major depressive episode. Patients with generalized social phobia and patients with specific social phobia had comparable past rates of major depression (37% and 30%, respectively). The clinical and theoretical implications of these findings are discussed within the context of current concepts regarding the development of depressive symptoms in patients with anxiety disorders.
PTH-142 Laparoscopic assisted surgery (Intraluminal Surgery): gastroduodenal lesions resecction and laparoscopic monitored colonoscopic polypectomy (LMCP). texas endosurgery institute experience
Authors: MA Hernandez, ME Franklin, JL Glass
Journal: Gut (2015)

<h3>Introduction</h3> Intraluminal surgery began with the advent of endoscopy. Laparoscopic assisted intraluminal technique is a novel alternative to open or laparoscopic surgery. Endoscopic lesions resection is limited for the view of endoscopic, insufficient number of instrument channels, and the inability to obtain adequate margins without risking perforation. The aim of this study is to demonstrate the feasibility and safety of the use of a hybrid technique. <h3>Method</h3> From May 1990 to February 2015, all patients undergoing LMCP and early gastric and duodenal lesions were analysed and prospectively followed with control endoscopy studies, 6 months, 1 year and every year there after. Operations were performed laparoscopically in conjunction with endoscopy. <h3>Results</h3> 24 patients were undergoing to gastro-duodenal lesions resection. 10 early gastric cancer (Stage I), 6 wedge of carcinoid tumour, 4 duodenal adenocarcinoma and 4 malignant polyps at the gastro-oesophageal junction. 320 colonic polyps were removed in 270 patients. 229 polyps were adenomas (114 tubular-villus, 58 villus, and 57 tubular), 66 were carcinomas (40 mod diff, 26 highly diff), 25 with other histologic type. <h3>Conclusion</h3> Long-term follow-up demonstrated that intraluminal surgery for early gastric and duodenal cancer is a feasible and safe alternative. Malignant lesions identified during LMCP can be treated laparoscopically during the same operation. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Overholt BF. Clinical experience with the fibersigmoidoscope. Gastrointest Endosc. 1968;5:27 Nelson D. Colonoscopy and polypectomy. Hematol Oncol Clin North Am. 2002;16:867–874 Mehdi A, Closset J, Gay F, <i>et al</i>. Laparoscopic treatment of a sigmoid perforation after colonoscopy: case report and review of the literature. Surg Endosc. 1996;10:666–667 Franklin ME Jr, Diaz-E JA, Abrego D, <i>et al</i>. Laparoscopicassisted colonoscopic polypectomy: the Texas Endosurgery Institute experience. Dis Colon Rectum. 2000;43:1246–1249 Franklin ME, Abrego D, Balli J. Combined laparoscopic and flexible endoscopic techniques in the management of malignant gastrointestinal lesions. Semin Surg Oncol. 1998;15:183–188 Franklin ME Jr, Leyva-Alvizo A, Abrego-Medina D, <i>et al</i>. Laparoscopically monitored colonoscopic polypectomy: an established form of endoluminal therapy for colorectal polyps. Surg Endosc. 2007;21:1650–1653
The purine analogs--a therapeutic beauty contest.
Authors: B D Cheson
Journal: Journal of Clinical Oncology (1992)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1992.10.3.352 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 1346799 The purine analogs--a therapeutic beauty contest. B D ChesonxB D ChesonSearch for articles by this author https://doi.org/10.1200/JCO.1992.10.3.352 First Page PDF © 1992 by American Society of Clinical Oncology
Dalteparin versus Unfractionated Heparin in Critically Ill Patients
Authors: Deborah Cook, Maureen Meade, Gordon Guyatt, Stephen Walter, Diane Heels-Ansdell, Theodore E Warkentin, Nicole Zytaruk, Mark Crowther, William Geerts, D Jamie Cooper, Shirley Vallance, Ismael Qushmaq, Marcelo Rocha, Otavio Berwanger, Nicholas E Vlahakis
Journal: New England Journal of Medicine (2011)

The effects of thromboprophylaxis with low-molecular-weight heparin, as compared with unfractionated heparin, on venous thromboembolism, bleeding, and other outcomes are uncertain in critically ill patients.
Effect of drug ritual changes on schizophrenic patients
Authors: R W Burgoyne
Journal: American Journal of Psychiatry (1976)

The author evaluated the charts of 115 chronic schizophrenic patients who regularly attended a follow-up group to determine whether changes in long-standing medication regimens produced an increased dropout rate, decreased attendance, or psychotic decompensation. He found that although there were nonsignificant trends showing a relationship between medication change and group attendance for individual patients, there were no significant difference between group attendance and change or no change in medication routine for the group of patients as a whole. He concludes that necessary changes in medication routines for chronic schizophrenic patients are safe.
Decision Tree for Liver Resection for Hepatocellular Carcinoma
Authors: Jacqueline M. Garonzik-Wang, Maria B. Majella Doyle
Journal: JAMA Surgery (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Surgery HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Surgery journal
Psychosomatic Aspects of Patients on Hemodialysis
Authors: Isao Fukunishi
Journal: Psychotherapy and Psychosomatics (1989)

Psychosomatic aspects of dialysis patients with diabetic nephropathy were examined using various psychological tests such as the MMPI Alexithymia Scale. Alexithymic traits were observed in 83% of dialysis patients with diabetic nephropathy. Moreover, positive correlations between alexithymia and self-control were found suggesting that alexithymic trait, the lack of awareness of one's own body, results in sluggish self-control, and affects prognosis of dialysis patients seriously. Especially, visual disturbance complications such as severe retinopathy are likely to further accelerate this condition. Therefore, it is essential for dialysis patients with alexithymic trait to acquire body awareness.
FRI0179 Reducion in Complement C3 and C4 Levels Greater with Tocilizumab as Compared to Anti-TNF in Patients with Rheumatoid Arthritis
Authors: N. Okumura, T. Kawasaki, S. Imai, K. Kumagai, K. Oda, Y. Matsusue
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> A reduction in complement levels during anti-TNF treatment in patients with rheumatoid arthritis (RA) has been described. However, there are no reports regarding changes in complement levels with the use of Tocilizumab (TCZ). <h3>Objectives</h3> In this study, we investigated changes in complement levels during TCZ treatment and compared them to those with anti-TNF treatment in patients with RA. <h3>Methods</h3> We measured C3 and C4 levels in 25 patients treated with TCZ and 44 treated with anti-TNF. In addition, major disease activity indicators were monitored before and 1 year after the initiation of treatment. <h3>Results</h3> Disease activities (DAS28-ESR) were significantly improved in both groups after 1 year. Furthermore, C3 and C4 concentrations were significantly reduced in both after 6 months and 1 year, though those effects were significantly more pronounced in the TCZ group than the anti-TNF group (graphs A and B, p&lt;0.001). Notably, patients in the TCZ group who showed a reduction in C4 to under the lower limit had significantly lower disease activity than others (graph C). <h3>Conclusions</h3> TCZ more effectively reduces complement C3 and C4 in patients with RA as compared with anti-TNF. Our results also indicate that C4 may be usable as a biomarker in RA patients undergoing TCZ treatment. <h3>References</h3> Di Mucio G, Perricone C, Ballanti E, et al. 2011. Complement system and rheumatoid arthritis: relationships with autoantibodies, serological, clinical features, and anti-TNF treatment. Int J Immunopathol Pharmacol; 24(2): 357-66. <h3>Disclosure of Interest</h3> None declared