tbuckley/cabot-search huggingface dataset:
SAT0609 Vitamin D Beneficial Effect on Arterial Hypertension
Authors: F. Salma, A. Omezzine, M. Turki, H. Fourati, M. Ezzedine, M. Chaabane, N. Salem, S. Baklouti, F. Ayadi
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Both vitamin D deficiency and hypertension are increasingly prevalent public health concerns in developing countries. <h3>Objectives</h3> This study aims to assess 25-hydroxyvitamin D (25(OH)D) status in postmenopausal women and to analyze its relationships with arterial hypertension. <h3>Methods</h3> A total of 200 tunisian postmenopausal women aged from 50 to 89 years were recruited from the rheumatology departement in CHU Hedi Chaker, Sfax, Tunisia. Clinical characteristics and patient medical history were collected using a validated questionnaire. Blood samples were taken for measurements of vitamin D, intact parathyroid hormone (PTH), and routine chemical analysis. Serum 25(OH)D and PTH were measured by electrochemiluminescence. SPSS 20 was used for the statistical analysis. <h3>Results</h3> The mean age was 63,74 ± 7,8 years. Mean PTH was 61,80 ± 25,6 ng/L. Serum 25(OH)D levels were below 10, 20, and 30 ng/ml in 55, 30.5 and 14.5% of participants, respectively. Systolic blood pressure (SBP) was above 140mmHg in 60,5% of the patients while 26.5% had a diastolic blood pressure (DBP) higher than 90mmHg. PTH was highly correlated to 25(OH)D (r=-0,305, p&lt;0,001) but not to the blood pressure levels. Serum 25(OH)D levels were negatively correlated to SBP (r=-0,121, p=0,045) and to HBP(r=-0,163, p=0,021). After multivariate adjustment for a range of potential covariates (Age, Body mass index, waist size and glomerular filtration rate) in a binary logistic regression model, a significant inverse association was found between serum 25(OH)D concentration and systolic hypertension risk: In fact Risk of systolic hypertension seems to be lowered in the group with high 25(OH)D levels (≥15 ng/mL) compared with those with low levels (&lt;15 ng/mL) (adjusted OR=0,512, CI 0.270–0.972), p=0,03). However, we have not noted a significant association between vitamin D levels and the risk of systolic hypertension (adjusted OR=1.01, 95% CI=0.495–2.064, p=0,97). <h3>Conclusions</h3> This study is timely, because a discrepancy exists between findings from observational studies and results of randomized intervention trials. Reverse causation, inherent weakness of observational studies, is a possible explanation as individuals with hypertension might have more chronic diseases and therefore spend less time outdoors with sun exposure, important for endogenous vitamin D production. In fact, randomized intervention trials will be needed to determine whether vitamin D supplementation can be used to prevent or treat hypertension. <h3>References</h3> Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol 2014; 2: 76–89. Tamez H, Thadhani RI. Vitamin D and hypertension: an update and review. Curr Opin Nephrol Hypertens 2012; 21: 492–99. <h3>Disclosure of Interest</h3> None declared
Evaluation of Interaction Between NK Cells and Colorectal Carcinoma Cells for Development of NK Cell-Based Immunotherapy in Patients with Refractory Disease
Authors: Elisabetta Todisco, Ilaria Turin, Federica Ferulli, Matteo Tanzi, Silvia Brugnatelli, Sara Delfanti, Marcello Maestri, Matteo Donadon, Matteo Cimino, Guido Torzilli, Armando Santoro, Paolo Pedrazzoli, Daniela Montagna
Journal: Blood (2014)
SAT0459 Associations between Body Composition Measures of Obesity and Radiographic Osteoarthritis in Older Adults: Data from The Dong-gu Study
Authors: K.-E. Lee, L. Wen, Y.-R. Yim, J.-E. Kim, J.-W. Lee, D.-J. Park, S.-S. Lee
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Objectives</h3> We examined the effects of fat deposition on radiographic osteoarthritis (OA) to determine the role of obesity in the pathogenesis of radiographic OA. <h3>Methods</h3> Data were taken from the Dong-gu cohort, a cross-sectional study of 2,367 subjects. Baseline characteristics, waist circumference (WC), waist-to-hip ratio (WHR), fat mass, and fat percentage were collected, along with X-rays of the knees and hands. Total knee and hand radiographic OA scores were summed using a semi-quantitative grading system, and then stratified by gender using a multiple linear regression model. <h3>Results</h3> After adjusting for confounders, weight was the only factor significantly associated with knee radiographic OA, regardless of gender (all p&lt;0.01). Regarding the hand, fat percentage had the largest effect on radiographic OA in males (p=0.008), while WHR was the most significant factor in females (p=0.001). For the knee, fat mass was the most important factor for radiographic OA in males (p=0.001), while in females, body mass index was the most important factor (p&lt;0.001). Among the variables, only fat percentage was significantly related to both hand and knee radiographic OA in both genders (all p&lt;0.01). <h3>Conclusions</h3> Regardless of gender, mechanical stress was significantly associated with knee radiographic OA. Otherwise, fat deposition correlated with hand and knee radiographic OA in both genders, while the distribution of fat tissue was significantly associated with hand and knee radiographic OA only in females, with the largest effect on hand and knee radiographic OA. <h3>Disclosure of Interest</h3> None declared
In-Hospital Mortality After Elective Abdominal Aortic Aneurysm Repair
Authors: En Lin Goh, Swathikan Chidambaram
Journal: JAMA Surgery (2016)

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Effect of Temporal Changes in Therapeutic Exposure on Self-reported Health Status in Childhood Cancer Survivors
Authors: Kirsten K. Ness, Melissa M. Hudson, Kendra E. Jones, Wendy Leisenring, Yutaka Yasui, Yan Chen, Marilyn Stovall, Todd M. Gibson, Daniel M. Green, Joseph P. Neglia, Tara O. Henderson, Jacqueline Casillas, Jennifer S. Ford, Karen E. Effinger, Kevin R. Krull, Gregory T. Armstrong, Leslie L. Robison, Kevin C. Oeffinger, Paul C. Nathan
Journal: Annals of Internal Medicine (2016)

The effect of temporal changes in cancer therapy on health status among childhood cancer survivors has not been evaluated.To compare proportions of self-reported adverse health status outcomes among childhood cancer survivors across 3 decades.Cross-sectional. (ClinicalTrials.gov: NCT01120353).27 North American institutions.14 566 adults, who survived for 5 or more years after initial diagnosis (median age, 27 years; range, 18 to 48 years), treated from 1970 to 1999.Patient report of poor general or mental health, functional impairment, activity limitation, or cancer-related anxiety or pain was evaluated as a function of treatment decade, cancer treatment exposure, chronic health conditions, demographic characteristics, and health habits.Despite reductions in late mortality and the proportions of survivors with severe, disabling, or life-threatening chronic health conditions (33.4% among those treated from 1970 to 1979 and 21.0% among those treated from 1990 to 1999), those reporting adverse health status did not decrease by treatment decade. Compared with survivors diagnosed in 1970 to 1979, those diagnosed in 1990 to 1999 were more likely to report poor general health (11.2% vs. 13.7%; P < 0.001) and cancer-related anxiety (13.3% vs. 15.0%; P < 0.001). From 1970 to 1979 and 1990 to 1999, the proportions of survivors reporting adverse outcomes were higher (P < 0.001) among those with leukemia (poor general health, 9.5% and 13.9%) and osteosarcoma (pain, 23.9% and 36.6%). Temporal changes in treatment exposures were not associated with changes in the proportions of survivors reporting adverse health status. Smoking, not meeting physical activity guidelines, and being either underweight or obese were associated with poor health status.Considerable improvement in survival among children diagnosed with cancer in the 1990s compared with those diagnosed in the 1970s makes it difficult to definitively determine the effect of risk factors on later self-reported health status without considering their effect on mortality.Because survival rates after a diagnosis of childhood cancer have improved substantially over the past 30 years, the population of survivors now includes those who would have died in earlier decades. Self-reported health status among survivors has not improved despite evolution of treatment designed to reduce toxicities.The National Cancer Institute.
THU0594 Towards Development of A Minimum Core Dataset and Standards of Data Collection for Observational Rheumatoid Arthritis Research – A EULAR Initiative: Table 1.
Authors: H. Radner, E. Nikiphorou, K. Chatzidionysiou, L. Gossec, K. Hyrich, C. Filip, Y. van Eijk-Hustings, P. Williamson, W. Dixon, J. Askling
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Collaborative research is compromised by heterogeneity of data collection in observational rheumatoid arthritis (RA) databases. Therefore a EULAR taskforce has been convened to develop a minimum core dataset (MCD) to 1) harmonize future data collection 2) act as a common data model existing databases can be mapped to 3) serve as a template for standardized data collection for RA research in clinical practice. <h3>Objectives</h3> To identify data items (i.e. "what to collect") and instruments (i.e. "how to collect") for inclusion in a MCD using an online survey. <h3>Methods</h3> First we performed a hierarchical literature review to identify data items and instruments of existing RA cohorts/registers. Extracted data presented in a separate abstract were used to develop an online survey to gather information from an expert panel involving Presidents of National Societies and selected representatives from each European country, patients, rheumatologists, other health professionals, and researchers. Experts were asked to rate importance of 48 different items and their instruments for possible inclusion in a MCD on a scale from 1 (not important) to 9 (very important). For analyses ratings of 1–3 (NO inclusion) and of 7–9 (INCLUSION) were combined and percentages of responses calculated. <h3>Results</h3> 90 experts from 28 different European countries (patients 18%, health professionals 18%, physicians 55%, researchers 10%) participated in the survey. 27/48 items were regarded to be important for inclusion in a MCD by &gt;80% of responders. Highest level of agreement to INCLUDE an item was found for: diagnosis of RA, composite scores, tender and swollen joint count (100%; table). Discrepancies of rating were observed for instruments: 24/126 instruments were rated as important for inclusion by &gt;80% of responders. <h3>Conclusions</h3> Based on expert ratings the majority of items were considered appropriate for inclusion into a MCD, leading to an extensive template. For most instruments no consensus was achieved. Results of the survey were moved forward onto the next phase of the project. <h3>Disclosure of Interest</h3> H. Radner: None declared, E. Nikiphorou: None declared, K. Chatzidionysiou: None declared, L. Gossec: None declared, K. Hyrich: None declared, C. Filip: None declared, Y. van Eijk-Hustings: None declared, P. Williamson: None declared, W. Dixon Grant/research support from: EULAR health professional research grant, J. Askling Grant/research support from: EULAR health professional research grant
TLR9 Agonist Immunomodulator Treatment of Cutaneous T-Cell Lymphoma (CTCL) with CPG7909.
Authors: Youn Kim, Michael Girardi, Madeline Duvic, Timothy Kuzel, Alain Rook, Brian Link, Lauren Pinter-Brown, Carol Comerci, Sonja McAuley, Tess Schmalbach
Journal: Blood (2004)
Conditionally Expressed PU.1 Transactivates TRAIL Gene and Induces Apoptosis in Myeloma Cell Lines.
Authors: Shikiko Ueno, Hiro Tatetsu, Hiroyuki Hata, Tadafumi IIno, Hiroaki Niiro, Koichi Akashi, Daniel G. Tenen, Hiroaki Mitsuya, Yutaka Okuno
Journal: Blood (2008)
SAT0023 Artery Tertiary Lymphoid Organs Occur in Giant Cell Arteritis
Authors: F. Ciccia, A. Rizzo, R. Alessandro, G. Guggino, S. Croci, S. Raimondo, A. Cavazza, C. Salvarani, G. Triolo
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Arteries are immuno-privileged sites. In advanced atherosclerotic lesions, however, adventitial lymphoid infiltrates, sometimes aggregated in lymphoid follicles (the so called artery tertiary lymphoid organs, ATLO), occur together with marked neoangiogenesis and lymphangiogenesis, and with the extensive induction of high endothelial venules. <h3>Objectives</h3> To investigate if tertiary lymphoid organs (TLO) are present in GCA and their formation is associated with the ectopic expression of constitutive lymphoid tissue-homing chemokines. <h3>Methods</h3> RT-PCR, immunohistochemical and immunofluorescence analysis were used to determine the presence of ectopic TLO in GCA and the expression of chemokines/chemokine receptors and cytokines involved in lymphoneogenesis in the artery samples obtained from 50 GCA patients and 30 controls. The presence of lymphatic conduits, of follicular dendritic cells (FDC) precursors and lymphoid tissue inducer cells was also investigated. Finally, expression of CXCL13 and BAFF by isolated vascular smooth muscle cells was evaluated before and after stimulation with toll like receptors agonists and cytokines. <h3>Results</h3> Artery TLO (ATLOs) were observed in the media layer of 60% of GCA patients in close proximity to neo-formed PNAD+ high endothelial venules. Pesence of ATLOs was independent by the number of infiltrating mononuclear cells, the age of patients and the presence of atherosclerosis. ATLO formation was also accompanied by the expression of CXCL13, BAFF, APRIL, IL-7 and IL-17. CXLC13 and BAFF expression was manily observed in the context of ATLOs, in VSMC and endothelial cells of neo-formed high endothelial cells. IL-7 and IL-17 expression levels were significantly correlated with the levels of CXCL13 and BAFF. The presence of follicular dendritic cells (FDC) precursors and of lymphoid conduits was demonstrated by confocal microscopy analysis and immunohistochemistry, respectively. Stimulation of VSMC with TLR agonists (LPS and poly-IC) and pro-inflammatory cytokines (IL-1b, IL-6, IFN-g and IL-17) resulted in the up-regulation of BAFF and CXCL13. <h3>Conclusions</h3> ATLOs occur in the inflamed arteries of GCA patients possibly representing the immune sites where immune responses toward unknown arterial wall-derived antigens may be organized. <h3>Disclosure of Interest</h3> None declared
International Validation of a Dithiothreitol (DTT)-Based Method to Resolve the Daratumumab Interference with Blood Compatibility Testing
Authors: Claudia I Chapuy, Maria D Aguad, Rachel T Nicholson, James P AuBuchon, Claudia S Cohn, Meghan Delaney, Joan Cid, Walter Dzik, Mark K. Fung, Andreas Greinacher, Ai Leen Ang, Dana V. Devine, Nancy M Dunbar, Henk Garritsen, Lawrence T Goodnough, Ross Herron, Tor A. Hervig, C. Michael Knudson, Jose M Kutner, Frank Nizzi, Suchitra Pandey, Benjamin Rioux-Masse, Kathleen Selleng, Joseph Sweeney, Minoko Takanashi, Aaron A.R. Tobian, Lorna Wall, Silvano Wendel, David A Westerman, Meredith Unger, Parul Doshi, Michael F. Murphy, Larry J. Dumont, Richard M. Kaufman, The BEST Collaborative
Journal: Blood (2015)
Forodesine (Immucillin H, BCX-1777) Shows Activity on Mantle Cell Lymphoma Primary Cells
Authors: Andrea Rinaldi, Emilia Ceresa, Davide Rossi, Gianluca Gaidano, Shanta Bantia, Chantal Y. Manz, Carlo Catapano, Emanuele Zucca, Francesco Bertoni
Journal: Blood (2008)
Can the Combination of the Measurement of BCR-ABL1 Transcript Levels At 3 and 6 Months Improve the Prognostic Value of the 3 Month Measurement?
Authors: Pratap Neelakantan, Gareth Gerrard, Letizia Foroni, Dragana Milojkovic, Jane Apperley, Richard Szydlo, Marco Bua, Alistair G Reid, Katy Rezvani, John M Goldman, David Marin
Journal: Blood (2012)
PTU-118 Comparison of Anal Sphincter Function Using Solid-State and Water-Perfused High Resolution Anorectal Manometry (HRAM) In Healthy Volunteers: Abstarct PTU-118 Table 1
Authors: A Rasijeff, M Withers, J Burke, W Jackson
Journal: Gut (2016)

<h3>Introduction</h3> To compare anal sphincter pressure parameters using water-perfused (WP) and a solid-state (SS) HRAM catheter in healthy volunteers using a standardised protocol to provide normal values. <h3>Methods</h3> 60 asymptomatic volunteers were studied (20 M/40 F). WP HRAM single-use ano-rectal catheters (ARC), 10 channels, external diameter 14 Fr (MUI Scientific, Canada) and SS HRAM multi-use ARC, 8 channels placed 0.8 cm apart, external diameter of 12 Fr, 16 Fr at sensors (UniSensor AG, Switzerland) both distributed by Ardmore Healthcare, UK. Studies were performed consecutively in a randomised order with the volunteers in the left-lateral position with knees &amp; hips flexed. After a 3 minute familiarisation period, the following test manoeuvres were performed according to a standardised protoco,<sup>1</sup> Rest- subject relaxed and lying still, anorectal pressures measured for 1 minute. Cough- asked to cough once maximally. Squeeze- asked to squeeze maximally for 5 seconds. Cough &amp; squeeze manoeuvres were repeated twice. Sensation of maximum rectal capacity was assessed by gradual inflation of the balloon at a rate of 2 ml/sec using an automated pump. <h3>Results</h3> Normal values (5 th-95th percentile) for parameters of ano-rectal function in males &amp; females using. <h3>Conclusion</h3> Significant differences between the two systems were observed for maximum squeeze increment and maximum cough increment in males &amp; females (p &lt; 0.001). There was no significant difference between the two catheter types in relation to anal canal length, resting pressure or maximum tolerated volume. This study utilised the same manometry system to record and analyse results, making it the first study to directly compare the impact of catheter choice on HRAM in normal volunteers. <h3>Reference</h3> 1 Carrington EV, <i>et al</i>. Traditional measures of normal anal sphincter function using HRAM) in 115 healthy volunteers. <i>Neurogastro &amp; Motility</i> 2014;<b>26</b>(5):625–635. <h3>Disclosure of Interest</h3> None Declared
Response-Adapted Sequential Azacitidine and Induction Chemotherapy in Patients &gt; 60 Years Old with Newly Diagnosed AML Eligible for Chemotherapy (RAS-AZIC): Results of the Phase I of the DRKS00004519 Study
Authors: Haifa Kathrin Al-Ali, Rainer Krahl, Michael Cross, Hubert Karolin, Nadja Jaekel, Dietger Niederwieser
Journal: Blood (2014)
AB0697 Does Vitamin D Affects The Severity of The Disease in Patients with Ankylosis Spondyloarthritis in A Sunny Country?
Authors: M. Djennane
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Vitamin D has been found to have a role in immune system function. It there9s been many studies on the relationship between vitamin D and disease activity in ankylosing spondyloarthritis (AS). However, studies have concerned the groups based on vitamin D levels and determined the differences between these patients in terms of disease activity, functional status, quality of life, and others clinical parameters. The aim of this study was to compare 25-hydroxyvitamin D (25 (OH) D) in patients with AS and healthy subjects and to determine the relationship between 25 (OH) D and activity disease, functional status and quality of life. <h3>Objectives</h3> The aim of this study is to compare 25-hydroxy-vitamin D3 (25(OH)D3) levels in AS patients with those in normal healthy subjects and to determine the relationship between 25(OH)D3 levels and AS disease activity, functional status, and quality of life. <h3>Methods</h3> hundred twenty-five consecutive patients and 76 healthy volunteers were included in this study. After a comparison between the patient group and the control group, the group of patients was divided into normal subgroups, deficient and inadequate function of plasma 25 (OH) D3 levels for another comparison <h3>Results</h3> Level differences 25 (OH) D between the patients and controls were statistically significant. The number of patients with AS whose rates 25 (OH) D were classified as normal, insufficient and deficient were respectively 32, 51 and 38. The sedimentation rate (ESR), C-reactive protein (CRP) and the scores Bath AS Disease Activity Index (BASDAI) were higher in the subgroup deficiency and 25OHD deficiency (P&lt;0.05). Bath functional scores (BASFI) and the quality of life (ASQoL) were significantly different between the subgroup with normal 25OHD levels and deficient subgroups (P&lt;0.05). Finally the level of pain, BASDAI, ESR and CRP were inversely correlated with 25OHD (P&lt;0.05) <h3>Conclusions</h3> Plasma levels of 25 (OH) D may be reduced in patients with ankylosing spondyloarthritis and this can negatively affect the activity of the disease, the functional status and quality of life. <h3>References</h3> Eva Klingberg and col. Osteoporosis in ankylosing spondylitis. Arthritis Res ther.2012; 14(3): R108. Sizheng Zhao and al. Systematic review of association between vitamin D level and susceptibility and disease activity of ankylosing spondylitis. Rheumatol 2014; 53: 1595–1603. <h3>Disclosure of Interest</h3> None declared
Salvage Chemotherapy Followed By Autologous Peripheral Stem Cell Transplantation for Relapsed Acute Promyelocytic Leukemia; A Single Center Experience
Authors: Yundeok Kim, Jung Yeon Lee, Hyun Sung Park, Ji Eun Jang, Soo-Jeong Kim, Jin Seok Kim, June-Won Cheong, Yoo Hong Min
Journal: Blood (2014)
The Tyrosine Kinase Inhibitor Adaphostin (NSC 680410), but Not Imatinib Mesylate, Inhibits Survival and Src Tyrosine Kinase Family- Triggered Signaling Pathways of MM Cells.
Authors: Klaus Podar, Melissa Simoncini, Yu-Tzu Tai, Martin Sattler, Kenji Ishitsuka, Steven Le Gouill, Makoto Hamasaki, Renate Burger, Noopur Raje, Teru C. Hideshima, Dharminder Chauhan, Kenneth Anderson
Journal: Blood (2004)