Calcium Intake and Cardiovascular Disease Risk
Authors: Mei Chung, Alice M. Tang, Sydne Jennifer Newberry
Journal: Annals of Internal Medicine (2017)

Letters2 May 2017Calcium Intake and Cardiovascular Disease RiskMei Chung, MPH, PhD, Alice M. Tang, SCM, PhD, and Sydne Jennifer Newberry, MS, PhDMei Chung, MPH, PhDFrom Tufts University, Boston, Massachusetts, and RAND Corporation, Santa Monica, California.Search for more papers by this author, Alice M. Tang, SCM, PhDFrom Tufts University, Boston, Massachusetts, and RAND Corporation, Santa Monica, California.Search for more papers by this author, and Sydne Jennifer Newberry, MS, PhDFrom Tufts University, Boston, Massachusetts, and RAND Corporation, Santa Monica, California.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L17-0136 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Dr. Samelson points out that no association was found between increasing Agatston scores (a marker of coronary artery calcification) and calcium intake levels from diet or supplements in the Framingham Heart Study (1). We agree that vascular calcification is a plausible biological mechanism for the potential pathogenesis of cardiovascular disease in relation to calcium supplementation. However, the effects of calcium supplementation on the prognosis of coronary artery calcification in general populations have not been well studied.Dr. Reid and colleagues highlight several views of evidence synthesis methods that are worthy of debate. Although we recognize that RCTs are ...References1. Samelson EJ, Booth SL, Fox CS, Tucker KL, Wang TJ, Hoffmann U, et al. Calcium intake is not associated with increased coronary artery calcification: the Framingham Study. Am J Clin Nutr. 2012;96:1274-80. [PMID: 23134889] doi:10.3945/ajcn.112.044230 CrossrefMedlineGoogle Scholar2. Murad MH, Asi N, Alsawas M, Alahdab F. New evidence pyramid. Evid Based Med. 2016;21:125-7. [PMID: 27339128] doi:10.1136/ebmed-2016-110401 CrossrefMedlineGoogle Scholar3. Lichtenstein AH, Yetley EA, Lau J. Application of systematic review methodology to the field of nutrition. J Nutr. 2008;138:2297-306. [PMID: 19022948] doi:10.3945/jn.108.097154 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Tufts University, Boston, Massachusetts, and RAND Corporation, Santa Monica, California.Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M16-1165. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoCalcium Intake and Cardiovascular Disease Risk Mei Chung , Alice M. Tang , Zhuxuan Fu , Ding Ding Wang , and Sydne Jennifer Newberry Calcium Intake and Cardiovascular Disease Risk Aisawan Petchlorlian Calcium Intake and Cardiovascular Disease Risk Joshua R. Lewis and Richard L. Prince Calcium Intake and Cardiovascular Disease Risk Ian R. Reid , Alison Avenell , Andrew Grey , and Mark J. Bolland Calcium Intake and Cardiovascular Disease Risk Elizabeth J. Samelson Metrics Cited byComparison of different calcium supplementation methods in patients with osteoporosis 2 May 2017Volume 166, Issue 9Page: 686-687KeywordsCalciumConflicts of interestCoronary artery calcificationNutrientsNutritionObservational studiesPathogenesisPopulation statisticsSystematic reviewsTraditional medicine ePublished: 2 May 2017 Issue Published: 2 May 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...