tbuckley/cabot-search huggingface dataset:
PWE-382 Outcomes from surgery for external rectal prolapse
Authors: C Warden, S Pilkington, T Dudding, P Nichols, K Nugent
Journal: Gut (2015)

<h3>Introduction</h3> To compare short and medium-term outcomes of surgery for external full thickness rectal prolapse at a single university institution, where Delorme’s procedure, laparoscopic posterior suture rectopexy and laparoscopic ventral mesh rectopexy are performed. <h3>Method</h3> Patients were identified from a prospective database. Consecutive patients undergoing surgery for rectal prolapse over a five year period between 2009 and 2014 were included. Patient data including age, gender, type of operation, hospital stay, complications, readmissions, duration of follow up, recurrence and mortality were recorded. The type of surgery was selected after careful discussion with each patient including the potential risks and complications specific to each of the three surgical procedures. Cases were also discussed at a pelvic floor multidisciplinary team meeting. <h3>Results</h3> During the study period, 77 patients underwent surgery with a median age of 74 years (range 18–90). A total of 69 (89.6%) were female. There were 20 (25.9%) patients who had previously undergone surgery for prolapse. A total of 20 (26%) Delorme’s procedures, 15 (19%) laparoscopic posterior suture rectopexies and 42 (55%) laparoscopic ventral mesh rectopexies were performed. The median (range) patient age was 79 (48–90) years, 74 (30–89) years and 79 (18–88) years respectively. Median follow-up was 35 (1–120) months. Recurrence rates were 23.8%, 13.3% and 4.7% respectively. Length of hospital stay was a median (range) of 2 (1–21) days, 3 (1–7) days and 2 (1–7) days respectively. There were no mesh related complications and no 60-day mortality. <h3>Conclusion</h3> Multiple operations have been described for rectal prolapse. At our institution, laparoscopic mesh ventral rectopexy had the lowest rate of recurrence with a similar length of hospital stay when compared with the alternatives of Delorme’s procedure and laparoscopic posterior suture rectopexy. Despite this, some patients may still opt for an operation with a higher recurrence rate to avoid potential complications such as mesh erosion. Longer term data is needed to assess these risks and inform patient choice. <h3>Disclosure of interest</h3> None Declared.
FRI0555 Osteoarticular Manifestations of Brucellosis: About Four Cases
Authors: R. Hajji, S. Zribi, N. Kammoun, M. Elleuch, F. Derbali
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The incidence of brucellosis has dramatically decreased in the developed countries. it still remains endemic in some areas such as the Southern Mediterranean region. The osteoarticular disease is the most common location of infectious complications of brucellosis, almost 30-85% of cases depending on the series. <h3>Objectives</h3> The aim of our work is to study the epidemiological, clinical, bacteriological and therapeutic osteoarticular brucellosis profile. <h3>Methods</h3> This is a retrospective study concerning four cases of osteoarticular brucellosis admitted in internal medicine department of Sidi Bouzid Regional Hospital over a period from 2011 to 2014. <h3>Results</h3> There were two men and two women, with an average age of 50 years. All patients had at least one risk factor (profession exposure in three cases and consumption of raw milk in four cases). The suduroalgic fever was constantly present, associated with a poor general condition in one case. Osteoarticular involvement was dominated by axial involvement in four cases (a case of lumbar spondylitis, a case of dorsal spondylitis, one case of cervical spondylitis and one case of unilateral sacroiliitis). Neurological signs were noted in two cases. Biology revealed an inflammatory syndrome in three cases. Serodiagnosis of Wright was positive in all the patients. Plain radiographs showed disc space narrowing associated with erosions of the vertebral endplates in three cases and localized erosion of the anterosuperior edge of the vertebra in one case. In the case of sacroiliitis, there was a pseudo-enlargement and irregularity of the articular space. The use of computed tomography and magnetic resonance imaging have revealed epidural extension in two cases and a paravertebral collection in two cases. The outcome was favorable under the rifampicin and doxycycline in three cases, with an average treatment duration of five months. One patient required a combination of antibiotics during one year associated with a surgical treatment. <h3>Conclusions</h3> Brucellosis remains a public health problem in countries with low socioeconomic level. The brucella serology should always be part of the etiological investigation of infectious osteoarthritis. However, primary prevention remains essential. <h3>Disclosure of Interest</h3> None declared
Hidden severe psychiatric morbidity in sentenced prisoners: an Australian study
Authors: H Herrman, P McGorry, J Mills, B Singh
Journal: American Journal of Psychiatry (1991)

The aim of this survey was to estimate the prevalence of severe mental disorders in a representative sample of sentenced prisoners.The subjects were selected as a random sample of sentenced prisoners in Melbourne's three metropolitan prisons. Interviews were conducted with 158 men and 31 women. Clinicians used the Structured Clinical Interview for DSM-III-R (SCID) to diagnose psychotic, affective, and substance use disorders.Six prisoners (3%) received current diagnoses of psychotic disorders, and 23 (12%) were diagnosed as having current mood disorders, mainly major depression. A lifetime diagnosis of at least one mental disorder each was made for 82% of the respondents, and in 26% more than one lifetime disorder was diagnosed. Sixty-nine percent received lifetime diagnoses of dependence on or abuse of alcohol, other psychoactive substances, or a combination of these.These findings do not indicate a large-scale shift of deinstitutionalized psychotically ill people from mental hospitals to prisons. They do, however, highlight the diversion into the corrections system of substance-dependent people and the apparent pool of prisoners with largely untreated major depression.
Case 49-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Sheila Sherlock, Benjamin Castleman
Journal: New England Journal of Medicine (1970)

Presentation of CaseA 61-year-old physician was admitted to the hospital because of pruritus.He had been well until 19 months previously, when diarrhea developed, accompanied by abdominal distress. He took several doses of prochlorperazine and believed that he had mild scleral icterus four or five days later. All symptoms subsided in a week without further treatment or investigation, and he continued an active medical practice and played squash. Eight months before admission the ingestion of rich, spicy foods was followed by recurrence of abdominal discomfort, and he again took 5 to 10 doses of prochlorperazine. During the next 10 . . .
HANS ZINSSER (1848-1940)—AS ONE REMEMBERS HIM
Authors: J H TALBOTT
Journal: JAMA (1964)

The book,<i>As I Remember Him, The Biography of R. S.</i>,<sup>1</sup>is an undisguised autobiography of Hans Zinsser, natural philosopher, bacteriologist, poet, and a highly rational intellectual. He was not one who appeared to be a different person to different individuals; rather these attributes and accomplishments were intimately interwoven, continually seeking expression in words or deeds. Through his personality and presentation of outstanding texts in infection and bacteriology, he exerted a great and profound influence on his students in the classroom and his research associates in the laboratory at a time when these subjects were approaching professional maturity in America. Hans was born in New York City, the first generation of German-born parents. His father was a successful chemist; his mother had been educated in a convent in the Black Forest. After being tutored at home, he spent a school year in Wiesbaden, Germany, and entered Columbia College, more
Treatment for Patients With Newly Diagnosed Glioblastoma
Authors: Marc C. Chamberlain
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PTH-087 Pre-screening tests for biological therapy: is clinical acumen enough?
Authors: W Taj-Aldeen, T Shaul, T cairnns, P Sherwood
Journal: Gut (2015)

<h3>Introduction</h3> Historically most Inflammatory Bowel Disease (IBD) patients on biological therapy have not been routinely screened for HIV, HBV, HCV, VZV immunity and TB at Northampton General Hospital. Our aim was to discover if any complication developed in patients who had not been screened according to the ECCO Guidelines for prevention of opportunistic infections. <h3>Method</h3> We reviewed retrospectively all IBD patients who received biological treatment over a period of six months (1<sup>st</sup>April 2013–4<sup>th</sup>November 2013). Previous blood tests and chest x-ray results were reviewed and patients invited to undertake any outstanding blood investigations. Clinical follow up notes were reviewed. <h3>Results</h3> 92 patients received a biologic in the six month period. Less than 20% had prior virology testing. Subsequently, all virology tests were negative (HIVx70, HBV x69, HCVx67). All patients tested for VZV had immunity. All chest x-rays were normal. The most notable finding was the result of the TB test as detailed in Figure 2 below. The clinical significance of this finding will be discussed later. A total of 67 patients were tested; 65 with the T-spot TB and 2 with Quantiferon-TB Gold, (the latter test was performed at a different hospital). Of these, only 16 patients (17%) were tested prior to commencement of treatment. A further 52 were tested during the audit. Of these, at the time of writing, three patients have an indeterminate T-spot TB result, two patients need retesting as their samples were unable to be processed and three patients were found to have a reactive T-spot TB test. The patients with a reactive T-spot TB test were all Caucasians and asymptomatic. They then had a chest x-ray performed, all of which showed no evidence of active TB. They have subsequently been referred to the Consultant TB Specialist for further review. <h3>Conclusion</h3> Routinely pre-screening patients for infections in accordance with ECCO guidelines at an early stage after their IBD diagnosis seems to be a reasonable precaution and will be our practice from now on. Given the reassuring findings from our retrospective testing, it seems unlikely that there is much to be gained by screening all low risk IBD patients who have already been exposed to immunosuppressants. <h3>Disclosure of interest</h3> None Declared. <h3>References</h3> Rahier JF, <i>et al</i>. (2014) Kenane J, <i>et al</i> Lawrance IC, <i>et al</i> Esteve M, <i>et al</i> Miyake Y, <i>et al</i>
Resolution of post-liver transplant anastomotic biliary stricture with successful placement of a self-expanding metallic stent in a child
Authors: William Sonnier, Devin Eckhoff, Stephen Gray, Jayapal Ramesh
Journal: Endoscopy (2015)

A 9-year-old girl who had received an orthotopic liver transplant for cryptogenic cirrhosis at the age of 5 years was admitted for the evaluation of elevated trans-aminases. Transabdominal ultrasound demonstrated intrahepatic biliary dilatation. Liver biopsy ruled out organ rejection, and endoscopic retrograde cholangiopancreatography (ERCP) confirmed the presence of a focal anastomotic stricture ([Fig. 1 a]).
Randomized Crossover Comparison of Personalized MPC and PID Control Algorithms for the Artificial Pancreas
Authors: Jordan E. Pinsker, Joon Bok Lee, Eyal Dassau, Dale E. Seborg, Paige K. Bradley, Ravi Gondhalekar, Wendy C. Bevier, Lauren Huyett, Howard C. Zisser, Francis J. Doyle
Journal: Diabetes Care (2016)

To evaluate two widely used control algorithms for an artificial pancreas (AP) under nonideal but comparable clinical conditions.After a pilot safety and feasibility study (n = 10), closed-loop control (CLC) was evaluated in a randomized, crossover trial of 20 additional adults with type 1 diabetes. Personalized model predictive control (MPC) and proportional integral derivative (PID) algorithms were compared in supervised 27.5-h CLC sessions. Challenges included overnight control after a 65-g dinner, response to a 50-g breakfast, and response to an unannounced 65-g lunch. Boluses of announced dinner and breakfast meals were given at mealtime. The primary outcome was time in glucose range 70-180 mg/dL.Mean time in range 70-180 mg/dL was greater for MPC than for PID (74.4 vs. 63.7%, P = 0.020). Mean glucose was also lower for MPC than PID during the entire trial duration (138 vs. 160 mg/dL, P = 0.012) and 5 h after the unannounced 65-g meal (181 vs. 220 mg/dL, P = 0.019). There was no significant difference in time with glucose <70 mg/dL throughout the trial period.This first comprehensive study to compare MPC and PID control for the AP indicates that MPC performed particularly well, achieving nearly 75% time in the target range, including the unannounced meal. Although both forms of CLC provided safe and effective glucose management, MPC performed as well or better than PID in all metrics.
Survival, Body Weights, and Lymphoid - Tissue Weights Following Adrenalectomy in CBA Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: Sumner N. Marder, M. D.
Journal: JNCI Journal of the National Cancer Institute (1950)

Survival, Body Weights, and Lymphoid - Tissue Weights Following Adrenalectomy in CBA Mice Get access Sumner N. Marder, M. D. Sumner N. Marder, M. D. research fellow Department of Radiology, Stanford University School of Medicine, San Francisco, Calif. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 1, August 1950, Pages 133–139, https://doi.org/10.1093/jnci/11.1.133 Published: 01 August 1950 Article history Published: 01 August 1950 Received: 06 August 1950
Personality Characteristics of Viet Nam veterans identified as heroin abusers
Authors: F W Black
Journal: American Journal of Psychiatry (1975)

The author presents data on the Minnesota Multiphasic Personality Inventory (MMPI) characteristics of a sample of enlisted Army men returning from Viet Nam identified as heroin abusers. Although a marked heterogeneity of MMPI profile types was found, a significant percentage of the subjects showed indications of marked psychopathology, and only a minority performed within normal limits on the MMPI. Theses military subjects showed neither greater nor less psychopathology and sociopathology than previously reported samples of civilian addicts.
Cloning and Expression of a Short Fas Ligand: A New Alternatively Spliced Product of the Mouse Fas Ligand Gene
Authors: Emira Ayroldi, Francesca D’Adamio, Ornella Zollo, Massimiliano Agostini, Rosalba Moraca, Lorenza Cannarile, Graziella Migliorati, Domenico V. Delfino, Carlo Riccardi
Journal: Blood (1999)
Withdrawal symptoms after graduated cessation of imipramine in children
Authors: W Law, T A Petti, A E Kazdin
Journal: American Journal of Psychiatry (1981)

In a systematic retrospective study the authors reviewed charts of 22 depressed children on a clinical research unit who were withdrawn from high-dose imipramine. Significant withdrawal symptoms were found over seven symptom categories despite an average tapering period of 6.4 days. These results suggest that withdrawal symptoms in children may be much more prevalent and intense than previously recognized.
Electron Microscopic Study of the Shope Papilloma Virus
Authors: Herbert Kahler, B. J. Lloyd, Jr.
Journal: JNCI Journal of the National Cancer Institute (1952)

Electron Microscopic Study of the Shope Papilloma Virus Get access Herbert Kahler, Herbert Kahler National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar B. J. Lloyd, Jr. B. J. Lloyd, Jr. National Cancer Institute2Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1167–1175, https://doi.org/10.1093/jnci/12.6.1167 Published: 01 June 1952 Article history Received: 04 January 1952 Published: 01 June 1952
Massachusetts Medical Society
Authors: John Figgis Jewett
Journal: New England Journal of Medicine (1975)

COMMITTEE ON MATERNAL WELFAREHERPES SIMPLEX ENCEPHALITISIn July a 28-year-old gravida 2, para 1, died in coma nine days after spontaneous premature delivery at 28 weeks' gestation.The prenatal course was unremarkable until malaise and diffuse neurologic symptoms became apparent 10 days before admission. Anorexia, slurred speech, aphasia, recent amnesia, unexplained falls and erratic movements had developed. The obstetrician first learned of these episodes when the patient was admitted via ambulance shortly after convulsing. The temperature was 39.4°C, but other vital signs, including blood pressure and the fetal heart rate, were normal, as was the urinalysis. Pelvic and abdominal . . .
Mental patients' attitudes toward hospitalization: a neglected aspect of hospital tenure
Authors: R E Drake, M A Wallach
Journal: American Journal of Psychiatry (1988)

Recent research on hospital tenure has neglected mental patients' attitudes toward hospitalization. The authors consider problems with past research on these attitudes and examine "living preference"--the patient's preference for living in the hospital or the community. Assessments of patients' living preferences were obtained from clinicians working with 187 chronically mentally ill patients in a state hospital aftercare program. These assessments strongly predicted both components of hospital tenure--rehospitalization and in-hospital days--during a 1-year follow-up. The authors point out the conceptual, heuristic, and practical clinical advantages of examining living preference rather than traditional correlates of hospital tenure.
Energy expenditure of autoperfusing heart-lung preparation.
Authors: Riveron Fa, Ross Jh, Schwartz Ka, Casey G, Sanders O, Eisiminger R, Magilligan Dj
Journal: Circulation (1988)

The autoperfused heart-lung preparation was developed as a method for extending the acceptable donor-to-recipient interval in clinical heart-lung transplantation. Metabolic substrate enhancement has been shown to be necessary for the survival and homeostasis of the functioning preparation. To define basic metabolic requirements and to determine the resting energy expenditure of the working canine heart-lung preparation, two groups were studied. Ten canine heart-lung blocks were placed in a normothermic autoperfusion circuit. In Group 1 (n = 5), a hyperalimentation solution of balanced substrate was infused (15% dextrose, 4.25% amino acids, 8 meq magnesium sulfate, 30 IU/dl insulin, and 10% lipids). In Group 2 (n = 5), no substrate was given. The preparations were ventilated with a mixture of room air and 5% CO2 at a rate of 4 breaths/min to maintain physiological pH. Myocardial function was assessed by cardiac output determinations and mixed venous gases. Pulmonary function was assessed with arterial blood gases. The oxygen consumption (VO2) and carbon dioxide production (VCO2) were measured with a Metabolic Cart, and the resting energy expenditure was calculated. The mean survival time for Group 1 was 360 minutes, and all preparations were terminated electively. The mean survival time for Group 2 was 219 +/- 43 minutes (p less than 0.01) with congestive heart failure as the common terminal event. All parameters of cardiac function and blood gases remained within physiological limits without significant differences between groups. The resting energy expenditure, a measure of metabolic rate, was 2.5 +/- 0.3 kcal/hr in Group 1 and 1.0 +/- 0.2 in Group 2 at termination (mean +/- SD) (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
Renal 123I-MIBG Scintigraphy Before and After Kidney Autotransplantation
Authors: Linn C. Dobrowolski, Daan W. Eeftinck Schattenkerk, Mirza M. Idu, Bert-Jan H. van den Born, Hein J. Verberne
Journal: Clinical Nuclear Medicine (2015)

A 25-year-old man underwent an autotransplantation of his right kidney because of fibromuscular dysplasia–induced renal artery stenosis and subsequent hypertension. Since transplantation results in complete kidney denervation, it enabled assessment of renal sympathetic nerve activity changes using renal 123I-MIBG scintigraphy. Before and 2 weeks after transplantation 123I-MIBG, scintigraphy was performed. Uptake of 123I-MIBG in the left (control) kidney increased after transplantation with 4% at 15 minutes and 5% at 4 hours postinjection images, whereas 123I-MIBG uptake in the right transplanted kidney decreased with 21% at 15 minutes and with 29% at 4 hours, demonstrating renal 123I-MIBG changes after denervation.