Phase I Clinical and Pharmacology Study of Topotecan Given Daily for 5 Consecutive Days to Patients With Advanced Solid Tumors, With Attempt at Dose Intensification Using Recombinant Granulocyte Colony-Stimulating Factor
Authors: L. Saltz, M. Sirott, C. Young, W. Tong, D. Niedzwiecki, Y. Tzy-Jyun, Y. Tao, B. Trochanowski, P. Wright, K. Barbosa, F. Toomasi, D. Kelsen
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article Phase I Clinical and Pharmacology Study of Topotecan Given Daily for 5 Consecutive Days to Patients With Advanced Solid Tumors, With Attempt at Dose Intensification Using Recombinant Granulocyte Colony-Stimulating Factor Get access Leonard Saltz, Leonard Saltz Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Correspondence to : Leonard Saltz, M.D., Gastrointestinal Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021 Search for other works by this author on: Oxford Academic PubMed Google Scholar Matthew Sirott, Matthew Sirott Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Charles Young, Charles Young Developmental Chemotherapy Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar William Tong, William Tong Developmental Chemotherapy Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Donna Niedzwiecki, Donna Niedzwiecki Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yao Tzy-Jyun, Yao Tzy-Jyun Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Yue Tao, Yue Tao Department of Biostatistics, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Bonnie Trochanowski, Bonnie Trochanowski Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Patricia Wright, Patricia Wright Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar Karen Barbosa, Karen Barbosa Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Frieda Toomasi, Frieda Toomasi Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar David Kelsen David Kelsen Gastrointestinal Oncology Service, Division of Medical Oncology, Department of Medicine, Memorial Sloan-Kettering Cancer Center, and The Cornell University Medical CollegeNew York, N.Y. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 18, 15 September 1993, Pages 1499–1507, https://doi.org/10.1093/jnci/85.18.1499 Published: 15 September 1993 Article history Received: 07 January 1993 Revision received: 03 May 1993 Accepted: 12 May 1993 Published: 15 September 1993