tbuckley/cabot-search huggingface dataset:
Transplantation with autologous bone marrow‐derived mesenchymal stem cells for alcoholic cirrhosis: Phase 2 trial
Authors: Ki Tae Suk, Jung‐Hwan Yoon, Moon Young Kim, Chang Wook Kim, Ja Kyung Kim, Hana Park, Seong Gyu Hwang, Dong Joon Kim, Byung Seok Lee, Sae Hwan Lee, Hong Soo Kim, Jae Young Jang, Chang‐Hyeong Lee, Byung Seok Kim, Yoon Ok Jang, Mee Yon Cho, Eun Sun Jung, Yong Man Kim, Si Hyun Bae, Soon Koo Baik
Journal: Hepatology (2016)

Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has been suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous BM-MSC transplantation in the treatment of alcoholic cirrhosis were investigated. Seventy-two patients with baseline biopsy-proven alcoholic cirrhosis who had been alcohol-abstinent for more than 6 months underwent a multicenter, randomized, open-label, phase 2 trial. Patients were randomly assigned to three groups: one control group and two autologous BM-MSC groups that underwent either one-time or two-time hepatic arterial injections of 5 × 107 BM-MSCs 30 days after BM aspiration. A follow-up biopsy was performed 6 months after enrollment, and adverse events were monitored for 12 months. The primary endpoint was improvement in fibrosis quantification based on picrosirius red staining. The secondary endpoints included liver function tests, Child-Pugh score, and Model for End-stage Liver Disease score. Outcomes were analyzed by per-protocol analysis. In terms of fibrosis quantification (before versus after), the one-time and two-time BM-MSC groups were associated with 25% (19.5 ± 9.5% versus 14.5 ± 7.1%) and 37% (21.1 ± 8.9% versus 13.2 ± 6.7%) reductions in the proportion of collagen, respectively (P < 0.001). In the intergroup comparison, two-time BM-MSC transplantation in comparison with one-time BM-MSC transplantation was not associated with improved results in fibrosis quantification (P > 0.05). The Child-Pugh scores of both BM-MSC groups (one-time 7.6 ± 1.0 versus 6.3 ± 1.3 and two-time 7.8 ± 1.2 versus 6.8 ± 1.6) were also significantly improved following BM-MSC transplantation (P < 0.05). The proportion of patients with adverse events did not differ among the three groups.Autologous BM-MSC transplantation safely improved histologic fibrosis and liver function in patients with alcoholic cirrhosis. (Hepatology 2016;64:2185-2197).
Chronic Opioid Use Pattern in Adult Patients with Sickle Cell Disease
Authors: Jin Han, Santosh L. Saraf, Xu Zhang, Michel Gowhari, Robert E. Molokie, Johara Hassan, Chaher Alhandalous, Jewel Younge, Taimur Abbasi, Roberto F. Machado, Victor R. Gordeuk
Journal: Blood (2015)
Clinical impact of <sup>11</sup>C-Choline PET/CT in selection and outcome of salvage cryoablation in patients with recurrent prostate cancer after radiotherapy.
Authors: Marleen Suzanne Vallinga, Anthonius Breeuwsma, Maxim Rybalov, Jan Pruim, Igle J. De Jong
Journal: Journal of Clinical Oncology (2016)

276 Background: Salvage cryoablation is an effective but toxic treatment for local recurrent prostate cancer after primary radiotherapy. To assess the location of recurrent prostate cancer, an 11 C-choline PET/CT can be used. We studied the clinical impact of 11 C-choline PET/CT on the choice for and the results of salvage cryoablation. Methods: A total of 141 patients with a biochemical recurrence (BCR according to ASTRO-Phoenix criteria) after radiotherapy, and thus candidates for salvage cryoablation, were included. Patients were re-staged with an 11 C-choline PET/CT, complementary prostate biopsies, when indicated a pelvic lymph node dissection and/or additional imaging. Change in choice of therapy was defined as major (no salvage cryoablation because of metastases or lack of local recurrence on PET/CT), minor (local salvage treatment was performed, but different technique of after additional diagnostics) or none (salvage cryoablation was performed). The impact of selection of patients for cryoablation with PET/CT on outcome was measured by time from cryoablation to BCR (according to Astro-Phoenix), first distant metastasis and start of hormonal therapy. Results: In 71 of 141 patients (51%) a change in therapy was implemented because of the result of 11 C-choline PET/CT. A major impact was observed in 48 (34%) patients. In 83 patients, a salvage cryoablation was performed (59%). 18% of this group showed no PSA response. Of the remaining patients with PSA response, 37% developed a BCR after mean 25.7 months. 47% of patients are still in remission after a mean follow-up of 43 months. In 16 of 83 patients (19%) metastases were proven after mean 55.4 months (SD 26.3). 15 patients started with hormonal therapy, mean 29.5 months (SD 20.1) after cryoablation. Conclusions: 11 C-choline PET/CT showed a significant impact on selection for salvage cryoablation. The choice for local salvage therapy was abandoned in 34% of patients. Of the men who underwent a salvage cryoablation, 47% stayed free of biochemical recurrence during mean 43 months follow-up.
HHS Announces Medical Bill Redesign Competition
Authors: Julie A. Jacob
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms
Authors: David A. Hinds, Kimberly E. Barnholt, Ruben A. Mesa, Amy K. Kiefer, Chuong B. Do, Nicholas Eriksson, Joanna L. Mountain, Uta Francke, Joyce Y. Tung, Huong (Marie) Nguyen, Haiyu Zhang, Linda Gojenola, James L. Zehnder, Jason Gotlib
Journal: Blood (2016)
P0059 : Meta-Analysis: SVR12 with simeprevir and sofosbuvir (SMV+SOF) for 12 weeks in 225 liver transplant (LT) recipients with HCV genotype 1 (HCV-1)
Authors: N.H. Nguyen, B.E. Yee, G.A. Lutchman, J.K. Lim, M. Nguyen
Journal: Journal of Hepatology (2015)
P-097 Hepatic artery embolization (HAE) in hepatocellular and gastroenteropancreatic neuroendocrine tumors at Instituto Oncologico Nacional, Panama
Authors: O. Castillo-Fernandez, H. Tapia, M. Ruiz, J. Pinto Llerena, M. Lim, Y. Pereira, L. Montano, M. Cukier
Journal: Annals of Oncology (2016)
The Treatment of Schizophrenia.
Authors: Emmanuelle Houy-Durand, Florence Thibaut
Journal: JAMA (1930)

Efficacy of neuroleptic treatment is well recognized in the treatment of schizophrenia. Both "Practice Guideline of Paris" (1994) and "the Practice Guideline of the APA" (1997) could advise psychiatrists in the choice of therapeutic strategies. The early recognition and management of a first episode of schizophrenia and the maintenance of antipsychotic medication at lower doses (for at least one year after a first episode, and five years after two or more relapses) seem to influence positively the long-term outcome of the disease. Despite the advantages of atypical neuroleptics with regard to extrapyramidal symptoms and their clinical efficacy in the short term treatment of schizophrenia, these treatments induce other side effects (cardiovascular or metabolic) that need to be further investigated; in addition, their long-term efficacy has not been adequately studied.
Dawn simulation treatment of winter depression: a controlled study
Authors: D H Avery, M A Bolte, S R Dager, L G Wilson, M Weyer, G B Cox, D L Dunner
Journal: American Journal of Psychiatry (1993)

This study sought to determine whether dawn simulation was superior to a shorter dimmer "placebo" dawn signal in treating winter depression.In a randomized, parallel design, 22 patients with winter depression were treated with either 1 week of a 2-hour dawn simulation peaking at 250 lux or 1 week of a 30-minute dawn simulation peaking at 0.2 lux. The subjects were told that they would receive either a "gradual" dawn or a "rapid" dawn reaching an intensity that would be dimmer than standard bright light treatment. At the end of both the baseline week and the treatment week, subjects were assessed in a blind manner with the Hamilton Rating Scale for Depression. Analysis of covariance was used to compare the two dawn treatments.The 2-hour, 250-lux dawn simulation resulted in Hamilton depression scale scores that were significantly lower than scores after the 30-minute, 0.2-lux dawn simulation.This study indicates that dawn simulation is an effective treatment for winter depression.
Development Of RNAi Therapeutics Targeting The Complement Pathway
Authors: Anna Borodovsky, Kristina Yucius, Andrew Sprague, James Butler, Shannon Fishman, Tuyen Nguyen, Akshay Vaishnaw, Martin Maier, Rajeev Kallanthottathil, Satya Kuchimanchi, Muthiah Manoharan, Rachel Meyers, Kevin Fitzgerald
Journal: Blood (2013)
Real-life study showing uncontrolled rhinosinusitis after sinus surgery in a tertiary referral centre
Authors: J. van der Veen, S. F. Seys, M. Timmermans, P. Levie, M. Jorissen, W. J. Fokkens, P. W. Hellings
Journal: Allergy (2016)

The European Position Paper on Sinusitis (EPOS) guidelines provide composite criteria to evaluate chronic rhinosinusitis (CRS) control, taking into consideration the severity of patients' symptoms, aspect of nasal mucosa and medical intake as parameters of CRS control.To study the degree of CRS control using novel EPOS control criteria at 3-5 years after a functional endoscopic sinus surgery (FESS) and correlate these data to symptoms scores.Adult CRS patients (n = 560) who had undergone bilateral FESS for chronic inflammatory sinonasal disease 3-5 years prior to the study were included. Patients received a postal questionnaire asking for control items according to EPOS control criteria, visual analogue scale (VAS) scores for total and individual sinonasal symptoms, sinonasal outcome test (SNOT)-22 and Short Form (SF)-36 questionnaires.About 19.5% of CRS patients were well controlled, with 36.8% of patients being partly controlled and 43.7% uncontrolled. The levels of control corresponded to mean total VAS, SNOT-22 and SF-36 scores. Subgroup analysis revealed that female gender, aspirin intolerance and revision FESS were associated with higher prevalence of uncontrolled CRS, whereas allergy, asthma and smoking status did not alter the percentage of patients in each category of control. In 81 patients attending the outpatient clinic, nasal endoscopy changed classification in only four patients (4.9%).Based on the novel EPOS control criteria, at least 40% of CRS patients are uncontrolled at 3-5 years after FESS. Therefore, better treatment strategies leading to higher disease control are warranted in CRS care.
The Mitochondrial Metabolism Inhibitor Cpi-613 Is Highly Active in Combination with High Dose Ara-C (HiDAC) and Mitoxantrone in a Phase I Study for Relapsed or Refractory Acute Myeloid Leukemia (AML)
Authors: Timothy S Pardee, Kristin Stadelman, Scott Isom, Leslie Renee Ellis, Dmitriy Berenzon, David D Hurd, Robin Harrelson, Megan Manuel, Sarah Dralle, Susan Lyerly, Bayard L. Powell
Journal: Blood (2014)
The Columnar Epithelial Cell of the Small Intestine: Digestion and Transport
Authors: Jerry D. Gardner, Michael S. Brown, Leonard Laster
Journal: New England Journal of Medicine (1970)

DIGESTION and absorption, the specialized functions of the intestinal columnar epithelial cell, appear to be intimately dependent on processes that can be localized to the plasma membrane. They may be coupled functionally within the membrane for greater efficiency, and the many similarities between their kinetics suggest that they reflect comparable processes. For example, enzymic digestion and carrier-mediated transport may be analogous activities of protein catalysts.1 In this review we consider the digestion of carbohydrates and proteins, and the transport of the resulting monosaccharides and amino acids. Recent evidence suggests that these functions are intimately associated with the microvillus.The Columnar . . .
Prognostic Impact Of MLL5 transcript Levels On Outcome Of Patients With Acute Promyelocytic Leukemia Treated With All-Trans Retinoic Acid and Anthracycline-Based Chemotherapy: An International Consortium On Acute Promyelocytic Leukemia Study
Authors: Antonio R Lucena-Araujo, Haesook T. Kim, Rafael Jacomo, Raul A Melo, Rosane Bittencourt, Ricardo Pasquini, Katia B. Pagnano, Evandro Fagundes, Maria de Lourdes L. F. Chauffaille, Ana S Lima, Hau C. Kwaan, Robert E Gallagher, Charlotte M. Niemeyer, Stanley L. Schrier, Martin S Tallman, David Grimwade, Arnold Ganser, Nancy Berliner, Raul Ribeiro, Francesco Lo-Coco, Bob Löwenberg, Miguel Sanz, Eduardo M. Rego
Journal: Blood (2013)
Incident opioid drug use and adverse respiratory outcomes among older adults with COPD
Authors: Nicholas T. Vozoris, Xuesong Wang, Hadas D. Fischer, Chaim M. Bell, Denis E. O'Donnell, Peter C. Austin, Anne L. Stephenson, Sudeep S. Gill, Paula A. Rochon
Journal: European Respiratory Journal (2016)

We evaluated risk of adverse respiratory outcomes associated with incident opioid use among older adults with chronic obstructive pulmonary diseases (COPD).This was a retrospective population-based cohort study using a validated algorithm applied to health administrative data to identify adults aged 66 years and older with COPD. Inverse probability of treatment weighting using the propensity score was used to estimate hazard ratios comparing adverse respiratory outcomes within 30 days of incident opioid use compared to controls.Incident opioid use was associated with significantly increased emergency room visits for COPD or pneumonia (HR 1.14, 95% CI 1.00-1.29; p=0.04), COPD or pneumonia-related mortality (HR 2.16, 95% CI 1.61-2.88; p<0.0001) and all-cause mortality (HR 1.76, 95% CI 1.57-1.98; p<0.0001), but significantly decreased outpatient exacerbations (HR 0.88, 95% CI 0.83-0.94; p=0.0002). Use of more potent opioid-only agents was associated with significantly increased outpatient exacerbations, emergency room visits and hospitalisations for COPD or pneumonia, and COPD or pneumonia-related and all-cause mortality.Incident opioid use, and in particular use of the generally more potent opioid-only agents, was associated with increased risk for adverse respiratory outcomes, including respiratory-related mortality, among older adults with COPD. Potential adverse respiratory outcomes should be considered when prescribing new opioids in this population.
"Superscan" in an autosomal-dominant benign form of osteopetrosis.
Authors: SUZY KIM, CHAN PARK, BYUNGSEOK KIM
Journal: Clinical Nuclear Medicine (2001)

From the Departments of Nuclear Medicine* and Orthopedics,† Ajou University School of Medicine, Suwon, Korea Received for publication August 9, 2000. Revision accepted November 6, 2000. Reprint requests: Chan H. Park, Department of Nuclear Medicine, Ajou University Hospital, San #5 Wonchun-dong Paldal-gu, Suwon 442-749, Korea. E-mail: [email protected]
Dear Ofcare . . .
Authors: Trisha Greenhalgh
Journal: BMJ (2007)

. . . I was pleased to hear that you're going to start levying fines on naughty NHS organisations that don't keep up standards. I've always been a believer that the punishment should fit the crime, so I herewith enclose some suggestions.

Firstly, I'd like you to pop into Seddle ward in St Fritters' Hospital (take the lift to the top floor, end of the corridor, first right) and set about that slovenly sister with the red hair. She wouldn't know a care protocol from the 263 bus timetable. And according to the woman I met in surgical outpatients, she's got a fancy man from Supplies whom she meets in the sluice while the student nurses are doing the drugs round. I'd respectfully suggest a two-year compulsory secondment to that nunnery at the top of the hill.

While you're at St Fritters, you should pay a visit to Catering. When my next-door neighbour was in having her gallbladder out, they kept sending up those cook-chill dinners (cooked on the outside, chilled on the inside, according to Gloria). And she found a human hair in the casserole. Personally, I'd make the head chef go on one of those Jamie Oliver courses and put up “five a day” posters in every ward at his own expense.

I don't really want to complain about the little cottage hospital as it's so convenient for my hip physio, but I'll do my duty. My nephew went to the A&E with a rugby injury (somewhere near the groin—I didn't like to ask). Apparently, the doctor's tie dragged right across the lad's pubes when he was examining him. Five minutes later, he was bending over a cot and the kiddy grabbed his tie and stuffed it in its mouth. It's a difficult one this, because I think they're all as bad as each other, so I recommend all the male doctors in that hospital should wear bow-ties for 12 months.

One final tip-off. The GP surgery on the corner of the High St has got a receptionist with a loose tongue. I was in the queue behind her in Asda the other day and she was spilling the beans about Mrs Connors' biopsy. What she needs in my view is for her smutty little diary to be scanned in and put on the practice website so the rest of us can poke our noses into her private business.

I do hope these suggestions help. Good luck with the new regulator.

Mildred Trotterby
Multicenter Phase II Trial of the Histone Deacetylase Inhibitor Depsipeptide (FK228) for the Treatment of Relapsed or Refractory Multiple Myeloma (MM).
Authors: Ruben Niesvizky, Scott Ely, Maurizio DiLiberto, Hearn J. Cho, Udi Y. Gelbshtein, David S. Jayabalan, Sangeeta Aggarwal, Janice L. Gabrilove, Roger N. Pearse, Karen Pekle, Faiza Zafar, Zoe Goldberg, John P. Leonard, John J. Wright, Selina Chen-Kiang, Morton Coleman
Journal: Blood (2005)
Tumor Screening and DNA Testing in the Diagnosis of Lynch Syndrome
Authors: Lydia Usha, Summer B. Dewdney, Lela E. Buckingham
Journal: JAMA (2016)

A 43-year-old woman with stage IA endometrial cancer had her tumor screened for DNA mismatch repair proteins and microsatellite instability and had 1 absent immunostain. How do you interpret the test results?
Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors
Authors: Jonathan M. Pitt, Marie Vétizou, Romain Daillère, María Paula Roberti, Takahiro Yamazaki, Bertrand Routy, Patricia Lepage, Ivo Gomperts Boneca, Mathias Chamaillard, Guido Kroemer, Laurence Zitvogel
Journal: Immunity (2016)
Functional imaging in liver tumours
Authors: Maxime Ronot, Ashley Kieran Clift, Valérie Vilgrain, Andrea Frilling
Journal: Journal of Hepatology (2016)

Functional imaging encompasses techniques capable of assessing physiological parameters of tissues, and offers useful clinical information in addition to that obtained from morphological imaging. Such techniques may include magnetic resonance imaging with diffusion-weighted sequences or hepatobiliary contrast agents, perfusion imaging, or molecular imaging with radiolabelled tracers. The liver is of major importance in oncological practice; not only is hepatocellular carcinoma one of the malignancies with steadily rising incidence worldwide, but hepatic metastases are regularly observed with a range of solid neoplasms. Within the realm of hepatic oncology, different functional imaging modalities may occupy pivotal roles in lesion characterisation, treatment selection and follow-up, depending on tumour size and type. In this review, we characterise the major forms of functional imaging, discuss their current application to the management of patients with common primary and secondary liver tumours, and anticipate future developments within this field.
Induction of Monocytic Differentiation by Tumor Necrosis Factor in Phorbol Ester-resistant KG-1a Cells
Authors: S Kharbanda, T Nakamura, R Datta, M L Sherman, D Kufe
Journal: Cancer Communications (1990)

Tumor necrosis factor (TNF) is a regulatory cytokine that has pleiotropic effects on hematopoietic cell growth and differentiation. The present studies have examined the effects of TNF on the differentiation of phorbol-ester resistant human KG-la leukemia cells. Treatment with 100 U/mL of TNF or 33 nM 12-O-tetradecanoylphorbol-13-acetate (TPA) had no detectable effect on the growth of KG-1a cells. In contrast, TNF, but not TPA, induced cellular aggregation and expression of the ICAM-1 adhesion molecule in KG-1a cells. Furthermore, KG-1a cells responded to TNF, but not to TPA, with a partial down-regulation of c-myc mRNA levels and induction of M-CSF gene transcription. Previous work suggested that TNF induces M-CSF gene expression through activation of phospholipase A2 and eicosanoid production. The present studies also demonstrate that TNF stimulated phospholipase A2 activity. In contrast, there was no detectable increase in phospholipase A2 activity following TPA treatment. These results indicate that: 1) certain characteristics of the differentiated monocytic phenotype were induced by TNF in the phorbol ester-resistant KG-1a line, and 2) treatment with TNF and not TPA was associated with activation of phospholipase A2 during induction of monocytic differentiation in these cells.
GP says “pointless” tendering of his practice caused staff to leave
Authors: Matthew Limb
Journal: BMJ (2015)

A GP is battling to maintain services after his primary care contract was made subject to competitive tender and “bundled” with those of two other practices.

Ashley Liston said that the tendering process by NHS Sunderland Clinical Commissioning Group (CCG) had already “destabilised” his practice in Washington, in Tyne and Wear, causing some staff to leave. He said that it would wreck the continuity of care and did not fit with the CCG’s locality focused approach, which was a core component of its plans to be a vanguard for new service models.

Liston told The BMJ , “This is an expensive, time consuming, and pointless exercise driven by the need to bring more ‘private’ sector into primary …
P-171 The impact on survival of CPT-11 as third-line or later treatment in advanced gastric cancer
Authors: A. Makiyama, K. Arimizu, G. Hirano, C. Makiyama, Y. Matsushita, T. Shirakawa, H. Ohmura, M. Komoda, K. Uchino, K. Inadomi, H. Kusaba, Y. Shinohara, M. Kuwayama, T. Kajitani, T. Esaki, E. Baba
Journal: Annals of Oncology (2016)
PD-004 Lactate dehydrogenase (LDH) levels predict benefit from the continuation of bevacizumab (bev) beyond progression in metastatic colorectal cancer (mCRC): subgroup analysis of the randomized BEBYP study
Authors: F. Marmorino, C. Cremolini, F. Loupakis, C. Antoniotti, C. Barbara, F. Dargenio, E. Miraglio, G. Masi, L. Salvatore, M. Schirripa, B. Borelli, L. Marcucci, L. Antonuzzo, S. Chiara, C. Banzi, D. Amoroso, A. Bonetti, A. Martignetti, M. Paris, L. Boni, D. Tomcikova, A. Falcone
Journal: Annals of Oncology (2016)