tbuckley/cabot-search huggingface dataset:
A five-year perspective on the situation of haemorrhagic fever with renal syndrome and status of the hantavirus reservoirs in Europe, 2005-2010
Authors: P Heyman, C S Ceianu, I Christova, N Tordo, M Beersma, M João Alves, Å Lundkvist, M Hukic, A Papa, A Tenorio, H Zelená, S Eßbauer, I Visontai, I Golovljova, J Connell, L Nicoletti, M Van Esbroeck, S Gjeruldsen Dudman, S W Aberle, T Avšić-Županc, G Korukluoglu, A Nowakowska, B Klempa, R G Ulrich, S Bino, O Engler, M Opp, A Vaheri
Journal: Eurosurveillance (2011)

Hantavirus infections are reported from many countries in Europe and with highly variable annual case numbers. In 2010, more than 2,000 human cases were reported in Germany, and numbers above the baseline have also been registered in other European countries. Depending on the virus type human infections are characterised by mild to severe forms of haemorrhagic fever with renal syndrome. The member laboratories of the European Network for diagnostics of Imported Viral Diseases present here an overview of the progression of human cases in the period from 2005 to 2010. Further we provide an update on the available diagnostic methods and endemic regions in their countries, with an emphasis on occurring virus types and reservoirs.
Safety of Recombinant Activated Factor VII in Randomized Clinical Trials
Authors: Veronica Yank, Randall S Stafford
Journal: New England Journal of Medicine (2011)

To the Editor: Levi et al. (Nov. 4 issue)1 report on their analysis of published randomized, placebocontrolled trials on the use of recombinant activated factor VII (rFVIIa) to treat life-threatening bleeding. We welcome the pooled data reporting the rate of arterial thrombosis observed when rFVIIa, particularly in large doses, was administered off-label to patients over the age of 65 years (9.0%), as compared with those 65 years of age or younger (3.8%). However, the quantification of a side effect (risk) without an assessment of benefit ignores the predominant clinical setting in which off-label rFVIIa is used. Pooling of groups of patients with different thrombotic and bleeding risks (i.e., active and not active bleeding, normal and abnormal coagulation, severe thrombocytopenia and normal platelet count) does not assist in clinical risk–benefit decisions, since it seems evident that such patients should be treated differently. Indeed, the use of rFVIIa in patients with severe hemorrhagic states was not associated with thrombosis. Thrombosis was associated with increasing doses of rFVIIa in patients with spontaneous bleeding in the central nervous system. The authors’ inclusion of data from older studies, in which doses of rFVIIa of more than 90 μg per kilogram of body weight were used, further undercuts the relevance of these data from current clinical practice, since we rarely use such high doses. Therefore, it is difficult to see how we can improve our risk–benefit decisions on the basis of these new data.
A memorable patient: Beating the test
Authors: Jonathan R Osborn, Yvette G M Coldicott
Journal: BMJ (2004)

An 89 year old woman with dementia is currently being managed in the community with six monthly visits from the community elderly mental health nurse and intensive family support. She is vivacious and intelligent and still regularly attempts the Daily Telegraph crossword, having previously held a prestigious position in the City of London. Her short term memory has recently deteriorated, and she depends on her diary for keeping appointments and knowing people's contact details.

We were therefore surprised to learn that she regularly receives high marks in the Folstein mini-mental state examination, which she completes during the visits from the mental health nurse. We were determined to discover the reason for this apparent anomaly.

It became clear that at the end of every visit by the nurse, while making the appointment for the next visit, the patient would record the correct answers to the mini-mental test in her diary. Just before the nurse's next arrival, she would read in her diary that she should “revise for test” and would learn the answers by heart, hence earning high marks. Several hours later, she would be unable to recall the questions or answers, but she would have the date of the next test and the required answers already written in her diary.

This case highlights two important lessons. Firstly, that objective tests form only one part of a clinical evaluation—along with history, examination, instinct, and experience. Secondly, it is a charming example of strength of personality and forethought overcoming adversity.
Complete Chemical Descriptions of Substances Tested
Authors: Fritz Bischoff, George Bryson
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Complete Chemical Descriptions of Substances Tested Get access Fritz Bischoff, Fritz Bischoff Santa Barbara Cottage Hospital, Research Institute, Santa Barbara, California 93105 Search for other works by this author on: Oxford Academic PubMed Google Scholar George Bryson George Bryson Santa Barbara Cottage Hospital, Research Institute, Santa Barbara, California 93105 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1383–1384, https://doi.org/10.1093/jnci/52.4.1383 Published: 01 April 1974
The Action of Methylcholanthrene, Croton Oil, and 1,2-Benzanthracene in the Induction of Skin Tumors in Strain DBA Mice&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;
Authors: Michael Klein
Journal: JNCI Journal of the National Cancer Institute (1952)

Journal Article The Action of Methylcholanthrene, Croton Oil, and 1,2-Benzanthracene in the Induction of Skin Tumors in Strain DBA Mice Get access Michael Klein Michael Klein Research Fellow National Cancer Institute4Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 4, February 1952, Pages 735–742, https://doi.org/10.1093/jnci/12.4.735 Published: 01 February 1952 Article history Received: 14 September 1951 Published: 01 February 1952
Screening is dead. Long live screening!
Authors: Ben Clarsen, Hilde Moseby Berge
Journal: British Journal of Sports Medicine (2016)

Most of us have done it, right? Screening athletes for injury risk has become a normal part of our jobs as sport and exercise medicine clinicians. Why? Most likely because targeting high-risk athletes with individualised prevention programmes is an extremely attractive idea. Unfortunately, however, it may also be a misguided idea. Professor Roald Bahr illustrates just how unrealistic it is to identify which athletes will and will not get injured using current risk factor screening tests.1

Similarly, Wright et al 2 highlight the inability of the extremely popular functional movement screen to predict injury. These papers challenge the entire concept of individually targeting high-risk athletes to prevent injury. We expect these papers to be real game changers—you will not screen without thinking about them.

So …
Multiple Risk Factor Intervention Trial
Authors: D Michel
Journal: JAMA (1982)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pulmonary Edema
Authors: Eugene D. Robin, Carroll E. Cross, Robert Zelis
Journal: New England Journal of Medicine (1973)

Anatomy and PhysiologyVERTEBRATES left the water and became air breathers approximately one billion years ago. This transition gave rise to a whole host of new problems, one of which was maintenance of the terminal spaces for gas exchange in a relatively dry state. Previously, it had been required to maintain an adequate volume flow of water and to keep gas-exchange units persistently wet. It was now required to keep these spaces persistently dry. This necessity called for an elaborate series of structural and functional adaptations to prevent flooding and preserve the integrity of pulmonary gas exchange.Failure of these . . .
Overview: research on the psychology of women. II. Women in families, work, and psychotherapy
Authors: A M Seiden
Journal: American Journal of Psychiatry (1976)

In the first part of this overview the author reviewed research on gender differences in behavior and women's sexual and reproductive lives, and discussed the social and intellectual context of the recent knowledge explosion in women's studies. In this second part she reviews recent research on selected aspects of the social psychology of women's lives. Highlighted themes include women in relationship to family structure and child rearing, work and achievement motivation, and implications for the psychiatric treatment of women that can be drawn from the psychotherapy research literature. She briefly assesses the possible impact of research in these areas on psychiatric theory and practice.
Soundings: Private views
Authors: Liam Farrell
Journal: BMJ (2000)

We are human and frail, so we understand human frailty. In the same way we can truly comprehend illness only when we have been ill ourselves; intellectual knowledge is no substitute for bitter experience.

A few years ago I had a colonoscopy. The procedure itself was no problem and even the mandatory anal catharsis was passable, almost a pleasant diversion, like a walk in the country (albeit the country of the very weird). Thomas More, in his Utopia, described defaecation as being one of the primary physical pleasures, though I reckon such an extreme expression of this activity was not quite what he had in mind. However, despite these pleasant memories, drinking three litres of laxative the night before was an ordeal every doctor should himself endure before inflicting it on others. The advice leaflet recommended that the solution be chilled, but trust me, ice cold glop tastes just as bad as lukewarm glop.

The experience has left me with an unpalatable aftertaste, but, on the upside, the gastroenterologist generously sent me some lovely pictures of my colon. Call me Narcissus, but the portfolio is as soft focused as a South Sea sunset; romantic, roseate, like a Martian cavern with disco lights, a hint of mystery behind every nook and crevice, the kind of place you could come round a corner and suddenly encounter Humphrey Bogart and Peter Lorre engaged in furtive conversation.

Not that there are any crevices, for the mucosal surface is as slick and smooth and admirable as a New Labour spin doctor; the walls not too mucousy, not too dry, just pleasantly moist. If my colon were a footballer, Barcelona and Juventus would be begging for my signature. I'd be a superstar, perhaps release an autobiography, a CD, write a best selling novel (if Jeffrey Archer can do it, why not my colon?), then the tabloids would be on my trail, perhaps exposing an illicit lavage, some compromising pictures of my colon in bed with Liz Hurley, then I'd be ruined; perhaps I'm taking this analogy too far.

So attractive though the pictures were, I don't boast about them nor show them off to my friends; there are some things a man just has to keep to himself, parts of the body too private and personal for public display, parts of the body even the most enthusiastic and uninhibited nudist would feel uncomfortable about advertising. My colon and I must remain undiscovered.
Soundings: Paging Dr Parris
Authors: James Owen Drife
Journal: BMJ (2001)

August. High summer and mid silly season. With parliament in recess, Britain's heavyweight political commentators have gone on holiday and the media have turned to trivia. Newspaper readers, grateful at first, soon tire of pap. They begin to long for autumn, when the journalists will sharpen their knives again.

For medical politicians, however, autumn never comes. One of the delights of being on the General Medical Council or, I daresay, the BMA council is that press scrutiny of individual members is almost non-existent. The institutions themselves are subject to routine criticism, but the doctors who run them are largely ignored—or, worse, treated with respect. Even their presidents are spared the cartoonist's pen.

I have never met Tony Blair and I glimpsed Gordon Brown only once, years ago in the students' union. But I know them as well as I know, say, Prince Charles or President Bush, because they are regularly dissected by well-informed writers. When they face important decisions, their options are discussed, the electorate is informed, and the politicians can gauge public opinion.

The medical electorate, by contrast, relies on glossies produced by its official organisations, or on trade newspapers written by lay people. There is no medical Matthew Parris waspishly observing which medical quangoholics are pompous windbags, or Blair toadies, or Trappist monks, or barking mad. Or, maybe, sensible and constructive.

And yet, at intervals, Britain's doctors—all 0.1 million of them—are sent a list of names, unknown or vaguely familiar, and asked to vote. Without feedback from the fourth estate, democracy is a farce. Some like it that way. Years ago, when the GMC discussed regional representation, a member told me, “We can't have this. Nobody who knows me would vote for me.” He was not joking, just stating a fact.

Sadly, “Dr Parris” is pie in the sky. No reader would be willing to pay for a journal devoted to professional politics. And no medical writer would want the job. Parliamentary sketchwriters are already struggling to make Westminster's cloned legislators seem interesting. Medical politicians would be an impossible challenge.

Dr Parris dot com? Perhaps the internet is the answer, but for me the words “heavyweight” and “web” are incompatible.
A new decline in preventive behaviours among homosexual men : the role of highly active antiretroviral therapy?
Authors: A Laporte
Journal: Eurosurveillance (2002)

The articles published in this issue of Eurosurveillance on recent trends of preventive behaviours in homosexual men in Spain, Switzerland, and the Netherlands, all conclude that the practice of safer sex is declining. They emphasise increases in anal penetration (regardless of the nature of the relationship), non-protected anal intercourse, and ejaculation in the mouth, in particular among casual partners. The increase of diagnoses of acute sexually transmitted diseases (such as gonorrhoea and syphilis) in different European countries - illustrated in this issue by the data from the Netherlands - is the first tangible consequence of this decline.
Seat Belt Use Among Adult Workers — 21 States, 2013
Authors: Winifred L. Boal, Jia Li, Rosa L. Rodriguez-Acosta
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Roadway incidents involving motorized vehicles accounted for 24% of fatal occupational injuries in the United States during 2013 and were the leading cause of fatal injuries among workers.* In 2013, workers' compensation costs for serious, nonfatal injuries among work-related roadway incidents involving motorized land vehicles were estimated at $2.96 billion.(†) Seat belt use is a proven method to reduce injuries to motor vehicle occupants (1). Use of lap/shoulder seat belts reduces the risk for fatal injuries to front seat occupants of cars by 45% and the risk to light truck occupants by 60%.(§) To characterize seat belt use among adult workers by occupational group, CDC analyzed data from the 2013 Behavioral Risk Factor Surveillance System (BRFSS) and found that not always using a seat belt was significantly associated with occupational group after controlling for factors known to influence seat belt use. Occupational groups with the highest prevalences of not always using a seat belt included construction and extraction; farming, fishing, and forestry; and installation, maintenance, and repair. To increase seat belt use among persons currently employed, states can enact and enforce primary seat belt laws, employers can set and enforce safety policies requiring seat belt use by all vehicle occupants, and seat belt safety advocates can target interventions to workers in occupational groups with lower reported seat belt use.
Predictive values of X-chromosome inactivation patterns and clinicohematologic parameters for vascular complications in female patients with essential thrombocythemia
Authors: Lee-Yung Shih, Tung-Liang Lin, Chang-Liang Lai, Po Dunn, Jin-Hou Wu, Po-Nan Wang, Ming-Chung Kuo, Lai-Chu Lee
Journal: Blood (2002)
Physical impairments in symptomatic femoroacetabular impingement: a systematic review of the evidence
Authors: Matthew Freke, Joanne L Kemp, Ida Svege, May Arna Risberg, Adam Ivan Semciw, Kay M Crossley
Journal: British Journal of Sports Medicine (2016)

Background Femoroacetabular impingement (FAI) and associated pathologies are associated with pain and reduced quality of life. Physical impairments can be associated with worse symptoms and may be an important target of rehabilitation programmes in this patient group. Knowledge regarding physical impairments in people with symptomatic FAI is limited. Hypothesis In adults aged 18–50 years with symptomatic FAI: (1) to identify physical impairments in range of motion (ROM), hip muscle function and functional tasks; (2) to compare physical impairments with healthy controls; and (3) to evaluate the effects of interventions targeting physical impairments. Study design Systematic review. Methods A systematic review of the literature was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. The modified Downs and Black checklist was used for quality appraisal. Studies of adults aged 18–50 years with symptomatic FAI that examined ROM, hip muscle function and functional tasks were included. Standardised mean differences were calculated where possible or best evidence synthesis and study conclusions were presented. Results Twenty-two studies fulfilled all inclusion criteria. Methodological quality was varied. Results for hip joint ROM differences between people with symptomatic FAI compared and control subjects were varied. People with symptomatic FAI demonstrated some deficits in hip muscle strength and reduced balance on one leg when compared with control subjects. For hip joint ROM and hip muscle strength results for within-group differences between preintervention and postintervention time points were limited and inconclusive. No randomised controlled trials evaluated the effect of different types of interventions for symptomatic patients with symptomatic FAI. Conclusions People with symptomatic FAI demonstrate impairments in some hip muscle strength and single leg balance. This information may assist therapists in providing targeted rehabilitation programmes for people with FAI and associated pathology. Further research is needed to determine whether symptomatic FAI affects other aspects of functional performance; and to evaluate whether targeted interventions are effective in symptomatic FAI. Clinical relevance This information may assist therapists in providing targeted rehabilitation programmes for people with symptomatic FAI.
Biochemical Modulation of 5-Fluoropyrimidine Toxicity by Dehydroepiandrosterone in Human Colonic Adenocarcinoma Cells
Authors: J Nyce, R C Klann, C T Holbrook
Journal: Cancer Communications (1990)

Exposure to dehydroepiandrosterone caused a concentration-dependent accumulation of HT-29 human colonic adenocarcinoma cells in S-phase and sensitization toward the cytotoxic effects of fluorouracil deoxyriboside but not 5-fluorouracil. These effects were synergistic at all tested concentrations of dehydroepiandrosterone (25-100 microM) and fluorouracil deoxyriboside (0.1-10 microM). Sterilization of cultures occurred at a fluorouracil deoxyriboside concentration of 1.0 microM in the presence of 50 microM dehydroepiandrosterone, while sterilization in the absence of dehydroepiandrosterone required nearly a 10-fold higher concentration of drug. Even in HT-29 cells selected for the ability to grow in 50 microM dehydroepiandrosterone, a synergistic response with fluorouracil deoxyriboside was observed. Double label experiments to examine the relative rates of incorporation of [14C]thymidine and [3H]uracil into DNA thymidine indicated that dehydroepiandrosterone exposure preferentially enhanced the de novo pathway for thymidylate synthesis, suggesting that this shift may have contributed to the observed synergism with fluorouracil deoxyriboside. Compared to controls, however, the salvage pathway for thymidylate biosynthesis was also stimulated following exposure to dehydroepiandrosterone. These results and the non-toxic nature of this naturally occurring steroid suggest that dehydroepiandrosterone may be useful as a biochemical modulator of fluorouracil deoxyriboside and, perhaps, other nucleoside analogs in cancer treatment.
LG-62DEVELOPING RISK-BASED SELECTION CRITERIA FOR THE NEXT SIOP TRIAL OF “SIGHT-SAVING THERAPY” FOR CHILDREN WITH NF1-ASSOCIATED OPTIC PATHWAY GLIOMA (NF1-OPG) - A CASE-BASED CONSENSUS SURVEY
Authors: David Walker, Astrid Sehested, Enrico Opocher, Tim Jaspan, Jo-Fen Liu, Rory Deasy, Amedeo Azizi, Ian Simmons, Rosalie Ferner, Jacques Grill
Journal: Neuro-Oncology (2016)
Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial
Authors: Tarik Asselah, Christophe Hézode, Roula B Qaqish, Magdy ElKhashab, Tarek Hassanein, George Papatheodoridis, Jordan J Feld, Christophe Moreno, Stefan Zeuzem, Peter Ferenci, Yao Yu, Rebecca Redman, Tami Pilot-Matias, Niloufar Mobashery
Journal: The Lancet. Gastroenterology & hepatology (2016)
RA-07FEASIBILITY OF EARLY POSTOPERATIVE<sup>18</sup>F-FET PET/MRI AFTER SURGERY FOR BRAIN TUMOR IN PEDIATRIC PATIENTS
Authors: Lisbeth Marner, Karsten Nysom, Astrid Sehested, Lise Borgwardt, René Mathiasen, Peder Skov Wehner, Otto M. Henriksen, Per Munck af Rosenschöld, Carsten Thomsen, Lars Bøgeskov, Helle Broholm, David Scheie, Torsten Lauritsen, Marianne Juhler, Liselotte Højgaard, Ian Law
Journal: Neuro-Oncology (2016)
Incidence of Thrombotic Complications with Use of Peg-Asparginase in Treatment for Acute Lymphoblastic Leukemia (ALL) in Adults and Young Adolescent Patients
Authors: David JM Routledge, Joanna Tomlins, Adrian Bloor, Kaz Mamat, Michael Dennis, Jim Cavet, Tim Somervaille, Sven Armin Sommerfeld, Samar Kulkarni
Journal: Blood (2015)
Modeling altered T-cell development with induced pluripotent stem cells from patients with RAG1-dependent immune deficiencies
Authors: Patrick M. Brauer, Itai M. Pessach, Erik Clarke, Jared H. Rowe, Lisa Ott de Bruin, Yu Nee Lee, Carmen Dominguez-Brauer, Anne M. Comeau, Geneve Awong, Kerstin Felgentreff, Yuhang H. Zhang, Andrea Bredemeyer, Waleed Al-Herz, Likun Du, Francesca Ververs, Marion Kennedy, Silvia Giliani, Gordon Keller, Barry P. Sleckman, David G. Schatz, Frederic D. Bushman, Luigi D. Notarangelo, Juan Carlos Zúñiga-Pflücker
Journal: Blood (2016)