tbuckley/cabot-search huggingface dataset:
Abnormal 131I Uptake in a Benign Serous Ovarian Cystadenoma Mimicking Bladder Physiological Uptake
Authors: Hong-Jun Song, Yan-Li Xue, Yan-Hong Xu, Zhong-Ling Qiu, Quan-Yong Luo
Journal: Clinical Nuclear Medicine (2012)

Iodine-131 (131I) whole-body scan is usually a routine practice for the management of patients with differentiated thyroid carcinoma after 131I therapy. The correct interpretation of radioiodine scans is critical and can avoid unnecessary therapeutic doses. 131I SPECT/CT plays an important role in the precise localization and characterization of 131I avid foci. We present a special case imaging resulting from a benign serous cystadenoma of the ovary mimicking physiological uptake of the urinary bladder, which was identified by 131I whole-body scan and 131I SPECT/CT.
Cushing's Syndrome in Patients with the Zollinger–Ellison Syndrome
Authors: Paul N. Maton, Jerry D. Gardner, Robert T. Jensen
Journal: New England Journal of Medicine (1986)

Reports of Cushing's syndrome in patients with the Zollinger-Ellison syndrome are rare, although up to 30 percent of gastrinomas contain ACTH-like immunoreactivity. We prospectively examined 75 patients with the Zollinger-Ellison syndrome for Cushing's syndrome. Three of 59 patients (5 percent) with the sporadic form of the Zollinger-Ellison syndrome had Cushing's syndrome, with severe symptoms due to ectopic production of ACTH. Each of these patients had metastatic gastrinoma, responded poorly to chemotherapy, and died within three years of the diagnosis of both syndromes. Three of 16 patients (19 percent) with the Zollinger-Ellison syndrome and multiple endocrine neoplasia type 1 had Cushing's syndrome due to pituitary production of ACTH, and their symptoms were mild. The gastrinoma in these patients was localized, and the prognosis was excellent. Thus, Cushing's syndrome is more common in patients with the Zollinger-Ellison syndrome than was previously reported, occurring in 8 percent of all cases. Furthermore, Cushing's syndrome in patients with sporadic Zollinger-Ellison syndrome and in those with multiple endocrine neoplasia type 1 differ in incidence, cause, clinical severity, extent of gastrinoma, the need for therapy, and prognosis. All patients with the Zollinger-Ellison syndrome and all patients with multiple endocrine neoplasia type 1 should be screened for Cushing's syndrome.
A Randomized Trial of Coronary Artery Bypass Surgery
Authors: Eugene Passamani, Kathryn B. Davis, Mary Jo Gillespie, Thomas Killip
Journal: New England Journal of Medicine (1985)

The Coronary Artery Surgery Study (CASS) was designed to compare medical and surgical treatment of selected patients with chronic, stable coronary artery disease. This report concerns a subset of patients with reduced ventricular function. Of 780 patients randomly assigned to medical or surgical treatment, 160 had ejection fractions above 0.34 but below 0.50 at base line and have been followed for an average of seven years. Eighty-two patients were assigned to medical therapy, and 78 to surgery; the two groups were comparable at base line with regard to prognostically important variables. At seven years, 84 per cent of patients in the surgical group were alive, as compared with 70 per cent of the medical group (P = 0.01). Nearly half the patients with impaired ventricular function had triple-vessel disease at entry; at seven years, observed survival in this group was 88 and 65 per cent for those assigned to surgical and medical treatment, respectively (P = 0.009). Survival of patients with single-vessel or double-vessel disease was similar in the two treatment groups. We conclude that patients with triple-vessel disease and ejection fractions higher than 0.34 but lower than 0.50 appear to have improved seven-year survival with elective bypass surgery.
AB0402 Avascular necrosis of hip in korean patients with systemic lupus erythematosus: risk factors and clinical outcome
Authors: J. Lee, S.-M. Jung, J.-H. Lee, S.-K. Kwok, K.-S. Park, S.-H. Park, H.-Y. Kim, Y.-G. Jeong, D. C. Jeong
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> AVN is a common manifestation in patients with systemic lupus erythematosus (SLE), which can cause significant disability. Nevertheless, the exact pathogenetic mechanism has not been clarified. <h3>Objectives</h3> To identify the risk factors for the development of avascular necrosis (AVN) and predictors for total hip replacement (THR) of the systemic lupus erythematosus (SLE) patients in Korea. <h3>Methods</h3> The medical records of 1051 patients with SLE were reviewed and 73 patients with AVN were identified. Among them, 64 patients were eligible for the analysis. Sixty-four age-and sex-matched SLE patients without apparent AVN were included as disease controls. The risk factors for development of AVN were examined by logistic regression analyses. The predictors for THR were determined by Cox proportional hazards regression analyses. <h3>Results</h3> Among 64 patients with AVN, 59 had AVN of the hip and 36 underwent THR. Independent risk factors for the development of AVN included cushingoid feature (OR 21.792, <i>P</i>=0.005), use of cyclophosphamide (OR 2.779, <i>P</i>=0.03) and azathioprine (OR 2.662, <i>P</i>=0.023). In Cox proportional hazards model, only advanced radiological stage of AVN (Association for Research on Osseous Circulation (ARCO) stage) was a statistically significant predictor for THR. In subgroup analysis with stage I-III AVN, multivariate Cox regression analysis showed NPSLE (HR 6.295, <i>P</i>= 0.001) and cumulative prednisolone dose in the first 6 months after AVN diagnosis &gt;0.9g (HR 3.238, <i>P</i>= 0.034) were independent predictors. <h3>Conclusions</h3> The advanced ARCO stage at the onset of AVN is an independent risk factor for THR in SLE patients with AVN. In ARCO stage I-III AVN, patients with NPSLE and patients who received more than 0.9g of prednisolone during the first 6 months after AVN diagnosis are likely to undergo THR. <h3>Disclosure of Interest</h3> None Declared
Multiple granular cell tumor of the colon
Authors: J. Soares, A. Machado, R. Gonçalves
Journal: Endoscopy (2010)

A 44-year-old man was referred to our endoscopy unit because of a family history of colorectal neoplasia. Colonoscopy revealed numerous semi-pedunculated polyps with intact mucosa, measuring 6 – 12 mm, in the cecum (n = 2), ascending (n = 5), and transverse (n = 2) colon. The two largest polyps, measuring 8 mm and 12 mm, respectively, and occurring in the ascending colon ([Fig. 1]), were removed by snare polypectomy. Histologic examination of the polyps revealed a submucosal tumor composed of cells with small round nuclei and abundant granular eosinophilic cytoplasm ([Fig. 2]). Immunohistochemical analysis showed the tumor cells expressed S-100 protein ([Fig. 3]). The resected polyps were diagnosed as granular cell tumor (GCT). Upper endoscopy, enteroscopy by videocapsule, and abdominal computed tomography scan were unremarkable. The patient entered an annual endoscopic follow-up program.
Atrial Septal Defect with Eisenmenger’s Syndrome Confirmed by Tc-99m MAA Scintigraphy
Authors: Shung-Shung Sun, Min-Kuei Tsai, Chao-Huei Yang, Chia-Hung Kao
Journal: Clinical Nuclear Medicine (2002)

SUN, SHUNG-SHUNG M.D.*; TSAI, MIN-KUEI B.S.†; YANG, CHAO-HUEI M.D.‡; KAO, CHIA-HUNG M.D.* Author Information
Abstract 18947: Circulating esRAGE is Associated with a Pro-Inflammatory/Pro-Atherothrombotic Profile in Familial Combined Hyperlipidemia Patients with Non-alcoholic Fatty Liver Disease
Authors: Francesca Santilli, Francesca Scarpini, Monica Bocchia, Alberto Fabbri, Stefano Lunghetti, Romina Navarri, Luca Puccetti
Journal: Circulation (2012)

Familial Combined Hyperlipidemia (FCHL) is the most common atherogenic lipid disorder, with FCHL patients representing 10-20% of premature myocardial infarction survivors. A significant overlap with non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MS) may suggest a common pathogenesis and explain the increased cardiovascular burden. Plasma levels of endogenous secretory receptor for advanced glycation-end-products (esRAGE), have been inversely associated with components of the MS, and may counteract RAGE-mediated pathogenesis, by acting as a decoy. We hypothesized that a ligand-RAGE pathway hyperactivity and inadequate endogenous protective response by esRAGE, as well as a number of pro-inflammatory and pro-atherothrombotic biochemical abnormalities, may be associated with the occurrence of NAFLD in a fraction of FCHL patients, even before and regardless of the diagnosis of MS. We performed a cross-sectional comparison among 72 patients with vs. 72 without NAFLD. Each group included FCHL alone, MS alone, and FCHL plus MS (n=24 each group). Regardless of the underlying biochemical abnormality (FCHL or MS), circulating esRAGE was significantly lower in patients with NAFLD as compared to their counterpart, in association with higher levels of CD40 ligand (CD40L), endogenous thrombin potential (ETP) and oxidized LDL and lower levels of IL-10 and adiponectin. MS and FCHL have additive effects on the above mentioned abnormalities. esRAGE was inversely related to CD40L and oxLDL and directly related to IL10 and adiponectin only in the groups with MS and NAFLD. Among patients with FCHL, those with the lowest esRAGE and highest degree of pro-inflammatory and atherothrombotic abnormalities coincide with the clinical diagnosis of NAFLD, regardless of MS, suggesting an interplay between adipokine secretion, oxidative stress and platelet/coagulative activation accelerating NAFLD occurrence as a proxy for cardiovascular disease.
Nonsteroidal Antiinflammatory Drugs — Differences and Similarities
Authors: John A. Oates, Alastair J.J. Wood, Peter M. Brooks, Richard O. Day
Journal: New England Journal of Medicine (1991)

John A. Oates, M.D., Editor Alastair J.J. Wood, M.D., Associate EditorTHE nonsteroidal antiinflammatory drugs (NSAIDs) are very commonly prescribed. This fact reflects the high prevalence of rheumatic diseases; approximately 8 percent of people have a rheumatic symptom at any one time. In 1984, it was estimated that nearly one in seven Americans was treated with an NSAID,1 and in 1986 100 million prescriptions were written for these drugs.2 During the past 30 years, there has been a substantial increase in the number of NSAIDs, but their availability varies markedly between countries.3 In the United States, at least until recently, . . .
Chlorambucil in Indolent Chronic Lymphocytic Leukemia
Authors: Guillaume Dighiero, Karim Maloum, Bernard Desablens, Bruno Cazin, Maurice Navarro, Robert Leblay, Michel Leporrier, Jérome Jaubert, Gérard Lepeu, Brigitte Dreyfus, Jacques-Louis Binet, Philippe Travade, François-Louis Turpin, Gérard Tertian, Agnès Bichoffe
Journal: New England Journal of Medicine (1998)

To determine whether chlorambucil treatment benefits patients with indolent chronic lymphocytic leukemia (CLL), we conducted two randomized trials in 1535 patients with previously untreated stage A CLL.
Percutaneous Rotational Pulmonary Thrombectomy
Authors: Abdurrahman Oguzhan
Journal: New England Journal of Medicine (2016)

A 77-year-old woman was admitted to the emergency department with chest pain, palpitations, and dyspnea. She received a diagnosis of pulmonary emboli. A video shows advancement of a pigtail catheter into the embolus site; tissue plasminogen activator was subsequently delivered directly into the clot.
SAT0436 Chronic widespread pain (CWP) and its association with burnout among female primary school teachers in southern province of sri lanka
Authors: P.V. De Silva
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Musculoskeletal problems and mental health problems are the commonest occupational health problems in the world today. Chronic musculoskeletal problems were found to be highly prevalent among female teachers and this was identified as a commonest cause of sickness absence of teachers in Sri Lanka. It has been reported that these teachers are commonly complaining musculoskeletal pain in multiple sites of the body. According to the latest studies, reporting chronic musculoskeletal pain is associated with job stress and other mental health disorders. However these problems have not been studied systematically among Sri Lankan teachers. <h3>Objectives</h3> This research was carried out to identify the prevalence of CWP and its association with burnout among the female primary school teachers in the Southern Province of Sri Lanka. <h3>Methods</h3> Six hundred and sixty female primary school teachers employed in the southern province of Sri Lanka were selected for the study using a multi-stage cluster sampling method. Data was collected on chronic musculoskeletal pains which persist for a period of three months or more during the last 12 months, using a structured self administered questionnaire with body manikins. A criterion given in the “Manchester Definition” for CWP was used for the identification of CWP. Burnout was identified using the validated Sinhala translation of Maslach Burnout Inventory-Educators Survey, which was specifically developed to identify the burnout of teachers. <h3>Results</h3> Out of the 660 selected teachers, 640 female primary school teachers completed the questionnaires with a non-response rate of 3.03%. Majority (62.1%) were older than 40 years of age and 56.1% had worked more than 10 years as a teacher. 10.2% of teachers were found to have CWP. Age above 40 years, residing more than 10 kilometers away from school, having more than 30 pupils in the class and engage in extracurricular activities in the school after the working hours were significantly associated (p&lt;0.05) with the CWP of teachers. CWP was significantly (p&lt;0.001) associated with burnout. However, CWP was not associated with ethnicity, marital status or with social class. <h3>Conclusions</h3> A high proportion of teachers had reported CWP and it was significantly more common among the teachers with burnout compared to the teachers without burnout. <h3>Disclosure of Interest</h3> None Declared
Abstract 894: Pancreatic cancer screening by TLR phenotyping
Authors: Jonathan S. Rosenberg, Sujay Singh, Sanjay Raul, Zhimin Tong, Sushovan Guha
Journal: Cancer Research (2011)

Abstract Background: Toll-like receptor (TLR) proteins play key roles in immune responses against infection. TLRs are normally associated with multiple chronic inflammatory diseases. As chronic inflammation often leads to development of neoplasia, we hypothesize that TLRs may promote neoplasia in distinct organ types. Elevated expression of some TLRs has been reported in many tumor tissues and/or tumor cell lines. It is known that in pancreatic ductal adenocarcinoma (PDAC), chronic inflammatory conditions often precede the tumorigenesis process. However, in this context a comprehensive analysis of expression of TLRs in PDAC is currently unknown. Aim: To investigate the expression of multiple TLRs in PDAC cells. Methods and Results: Multiple PDAC cell lines including AsPC-1, MIA PaCa2, PANC-1, PANC-28, and SW1990 were used for TLR phenotyping. The expression of TLRs including TLR2, 3, 4, 7 and 9 were analyzed by Flow Cytometry and Western Blotting techniques. We found that the expression of TLR2, 3, 4, 7 and 9 can be detected in MIA PaCa2, PANC-1, PANC-28, and SW1990 cells. However, the expression of TLR4 and TLR7 are very low in SW1990 cells when compared to MIA PaCa2, PANC-1, and PANC-28 cells. In AsPC-1 cells, the expression of TLR2, 4, and 7 are below the detection levels while the expression of TLR9 and TLR3 can be readily detected. Conclusion: The expression profile of TLRs is distinct among multiple PDAC cells. Using the PDAC cell lines as a model system we are assessing potential predictive value of TLRs as biomarkers in cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 894. doi:10.1158/1538-7445.AM2011-894
Ga-67 Muscle Uptake in a Weight Lifter After Exercise
Authors: JEFFERY W. KANSKI, BELKIS ERBAS, CHARLES D. RUSSELL, EVA V. DUBOVSKY
Journal: Clinical Nuclear Medicine (1997)

A 27-year-old man who had a history of Hodgkins lymphoma in apparent remission presented as an outpatient for restaging. A scintigram was obtained 7 days after injection of 11 mCi Ga-67 citrate. The patient had reinitiated a weight lifting regimen approximately 2 weeks before the imaging, noting arm tenderness after his first few workouts. The symptoms subsided and physical examination showed no tenderness to palpation. The patient denied any urinary discoloration after reinitiation of exercise. The scintigram showed localization of Ga-67 in both arms predominantly in the biceps, brachialis, and brachioradialis muscles. This finding corresponds to the site of previous tenderness. This study is an example of unusual Ga-67 uptake in muscle after exercise.
How Might Managed Care Affect the Indigent?
Authors: H. McIntosh
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article How Might Managed Care Affect the Indigent? Get access Hugh McIntosh Hugh McIntosh Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 13, 5 July 1995, Page 958, https://doi.org/10.1093/jnci/87.13.958 Published: 05 July 1995
Abstract 2658: Anti-GD3 antibodies are targeting molecules for delivery of RNAi to melanoma
Authors: Wu W. Michael, Genevieve Pare, Victor A. Tron
Journal: Cancer Research (2010)

Abstract Passive non-targeted delivery of RNAi therapy into tumours has been shown to be neither very effective, nor selective in vitro and in vivo. Consequently in this study, siRNA will be linked to a drug delivery system that will express a ligand that specifically targets melanoma cells. It has been previously shown that melanoma over-expresses the cell surface ganglioside GD3, thus, the anti-GD3 R24 monoclonal antibody can function as a targeting molecule. To do so, a targeting antibody was conjugated to a coated cationic liposome (CCL) exterior to effectively deliver RNAi to melanoma. Cell surface expression of GD3 on Malme 3M, LOX IMVI and SK-MEL-5 cells was verified by flow cytometry. Internalized levels of siRNA within CCLs were the quantified via spectrometry. Encapsulation efficiency of siRNA was calculated to be greater than 70%. The quantification of antibody expression on CCLs was measured, illustrating that while non-targeted CCLs showed insignificant values of antibody as expected, antibody-conjugated CCLs presented a decreasing trend of expression that can be explained by the multi-step purification process for the final CCL products. Fluorescent microscopy results, from the combination of internalized siRNA and Tex615 RNA within CCLs, displayed greater fluorescence with antibody-conjugated CCLs than non-targeted CCLs when Malme 3M, LOX IMVI, and SK-MEL-5 cells were treated. Taken together, these results conclude that the use of GD3-targeted liposomes can promote siRNA delivery to melanoma cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2658.
Uveitis and Pseudojaundice During a Regimen of Clarithromycin, Rifabutin, and Ethambutol
Authors: Stephen D. Shafran, Jean Deschenes, Mark Miller, Peter Phillips, Emil Toma
Journal: New England Journal of Medicine (1994)

To the Editor: We report the occurrence of uveitis and pseudojaundice in patients with AIDS who were receiving the combination of clarithromycin, rifabutin, and ethambutol for the treatment of Myco...
Identification of 15 different candidate causal point mutations and three polymorphisms in 19 patients with protein S deficiency using a scanning method for the analysis of the protein S active gene
Authors: S Gandrille, D Borgel, V Eschwege-Gufflet, M Aillaud, M Dreyfus, C Matheron, P Gaussem, JF Abgrall, B Jude, P Sie
Journal: Blood (1995)
Sodium valproate in Huntington's disease
Authors: G R Symington, D P Leonard, P J Shannon, F J Vajda
Journal: American Journal of Psychiatry (1978)

The authors assessed the effect of sodium valproate, which is thought to elevate brain gamma-aminobutyric acid (GABA) levels, in the treatment of Huntington's disease by an objective ultrasound method in three patients with Huntington's disease. Despite plasma levels ranging from 47.0 to 140.8 microgram/ml (mean, 104.7), sodium valproate had no beneficial effect on involuntary movements. The authors stress the importance of activation to achieve a standard level of arousal in the assessment of involuntary movements.
Association between Bacterial Vaginosis and Preterm Delivery of a Low-Birth-Weight Infant
Authors: Sharon L. Hillier, Robert P. Nugent, David A. Eschenbach, Marijane A. Krohn, Ronald S. Gibbs, David H. Martin, Mary Frances Cotch, Robert Edelman, Joseph G. Pastorek, A. Vijaya Rao, Donald McNellis, Joan A. Regan, J. Christopher Carey, Mark A. Klebanoff
Journal: New England Journal of Medicine (1995)

Bacterial vaginosis is believed to be a risk factor for preterm delivery. We undertook a study of the association between bacterial vaginosis and the preterm delivery of infants with low birth weight after accounting for other known risk factors.
AB0390 Hepatitis B – is the risk increased in patients with rheumatoid arthritis?
Authors: J. Karlsson Sundbaum, E. Arkema, N. Feltelius, J. Askling, E. Baecklund
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Several studies have shown an increased risk for infections in patients with rheumatoid arthritis (RA), including risk for hospitalization for infectious disease and an increased risk for certain types of infections such as pneumonia and herpes zoster. Lately, case reports have described reactivation of hepatitis B in RA patients treated with biological drugs, but it is not known whether the risk of hepatitis B is increased in RA patients in general. <h3>Objectives</h3> To assess if the risk of hepatitis B is increased in RA patients compared to the general population. <h3>Methods</h3> Risk of hepatitis B up until diagnosis of RA was estimated in a cohort of incident RA patients identified in the Swedish Rheumatology Quality Register (SRQ) 1999-2009. For each patient five general-population comparators were matched for sex, age and county of residence. Occurrence of hepatitis B in these cohorts was identified by linkage with the nationwide Swedish Patient Register (hospitalizations and outpatients visits in non-primary care) up until date of RA diagnosis. Risk for hepatitis B in patients diagnosed with RA was assessed using two RA populations (the above mentioned inception cohort from SRQ and a prevalent RA cohort identified on the basis of outpatient visits listing RA) 1999-2009. For each subject, five population-comparators were matched, and hepatitis B was identified as mentioned above. Relative risks were calculated using conditional logistic regression (OR) and Cox regression (HR), respectively. <h3>Results</h3> By the time of RA diagnosis 6 out of 7570 RA patients had an identified history of hepatitis B, compared to 52 cases among the 36778 general population comparators, OR=0.6; 95% CI 0.2-1.3.Counting from RA diagnosis in this cohort, 5 cases of hepatitis B were identified, compared to 12 cases among the controls HR=1.7; 95% CI 0.6-5.0.During follow-up of the prevalent RA cohort (n=46852,280000 person-years),22 patients were identified with hepatitis B,compared to 94 among the controls (n=215424,1903597,person-years), HR=1,4;95%CI 0,9-2,2. <h3>Conclusions</h3> We found no significantly increased occurrence of hepatitis B in RA patients in Sweden, neither before nor after RA diagnosis, compared to the general population. <h3>Disclosure of Interest</h3> None Declared