tbuckley/cabot-search huggingface dataset:
Spontaneously Resolving Lymphocele Demonstrated on Serial Renal Dynamic Scintigraphy
Authors: J Bharathi Dasan, Rakesh Kumar, Madhavi Tripathi,  Imlitemsu, Sandeep Guleria, Saikat Choudhury, Ashok Srinivasan
Journal: Clinical Nuclear Medicine (2002)

BHARATHI DASAN, J. M.D.; KUMAR, RAKESH D.N.B.; TRIPATHI, MADHAVI M.D., D.N.B.; IMLITEMSU, M.B.B.S.; GULERIA, SANDEEP M.S.; CHOUDHURY, SAIKAT M.B.B.S.; SRINIVASAN, ASHOK M.D. Author Information
Abstract 1164: <i>MTUS1</i> as a potential progression marker at chromosome 8p in bladder cancer
Authors: Anja Paola Rogler, Sabine Hoja, Arif Ekici, Bernd Wullich, Peter Goebell, Arndt Hartmann, Robert Stöhr
Journal: Cancer Research (2012)

Abstract Aims and background: The search for sensitive and specific progression and recurrence markers in bladder cancer is a major focus of many urological research groups. The aim of this study was to identify biomarkers on chromosome 8p in papillary urothelial carcinoma that give evidence for progression from non-invasive pTa to invasive pT1 stage. Candidate genes should be analyzed functionally in cell lines and validated immunohistochemically using tissue micro arrays. Material and methods: To find new progression markers 19 papillary urothelial carcinomas (9 pTa and 10 pT1) were investigated with array comparative genomic hybridization (aCGH) on Affymetrix Genome-Wide Human SNP Array 6.0. Therefore, tumor slides were manually microdissected, genomic DNA was isolated and DNA was hybridized on Affymetrix Chip together with reference DNA from 167 tumor-free patients. Computational analysis was performed with free Software “Genotyping-Console” from Affymetrix. MTUS1 gene and protein expression were investigated in bladder cancer cell lines and tumor tissue using qRT-PCR, Western blot and immunohistochemistry. Results: aCGH revealed more chromosomal aberrations overall as well as more deletions on chromosome 8p in pT1 tumors (50%) compared to pTa tumors (11%). Several putative progression-associated genes could be identified on 8p, for example SLC7A2, PDGFL, MTUS1, FGL1 and PCM1. MTUS1 (microtubule associated tumor suppressor 1) was chosen for further analysis, as in other tumor types this gene is known to be associated with frequent loss of heterozygosity at 8p22. However, to our knowledge, not much is known about its role in bladder cancer. Western blot analysis revealed expression of different isoforms in cell lines (140, 80 and 60 kDa) and tumor tissue (mainly 80kDa). Immunohistochemical staining of 128 papillary and 236 advanced tumors showed conflicting results compared to the aCGH findings. Conclusion: Whereas loss of genetic material at 8p22 harboring the MTUS1 gene is significantly associated with a pT1 stage in papillary urothelial carcinoma, pT1 tumors showed a significantly higher MTUS1 expression than pTa tumors as was shown by immunohistochemistry. At least in the pT1 group, expression loss contributed to worse overall survival, suggesting MTUS1 as a prognostic marker. Functional effects of MTUS1 overexpression will be analyzed in the future in RT112 cell line. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1164. doi:1538-7445.AM2012-1164
P160 The Role Of Specialist Palliative Care Services In The Management Of Patients With Pulmonary Arterial Hypertension; A Review Of Current Practice
Authors: S. Woolcock, J. De Soyza, R. Crackett, M. Day, A. Fisher, J. Lordan, G. MacGowan, P. Corris
Journal: Thorax (2014)

<h3>Introduction and objectives</h3> Pulmonary Arterial Hypertension (PAH) is a severe, progressive condition characterised by increased pulmonary vascular resistance, right ventricular failure and death. Survival is strongly linked to functional class with patients persisting in WHO class IV surviving less than one year. Such patients commonly require repeated hospital admissions with intractable symptoms due to right heart failure. Although specialist palliative care involvement is recommended in current guidelines for the management of PAH, no formal recommendations exist presently to guide clinicians on timing of referral. The aim of this study was to outline current practice in this area and define the potential workload and role of specialist palliative care services. <h3>Methods</h3> Data was collected retrospectively for all patients within our national PAH service who died over a one year period (June 2013–June 2014). We specifically looked at timing of referral and involvement of palliative care specialists, WHO functional class, clinical course prior to death and prognostic indicators of deterioration. Suitable patients were identified from the PAH and palliative care databases. Patient notes were reviewed to identify WHO class, clinical course prior to death and documented evidence of specialist palliative care involvement. <h3>Results</h3> 31 patients were identified; (14 male, 17 female; 19 (61%) WHO IV, 9 (29%) WHO III, 3 (10%) WHO II). Only 11 (35%) had documented evidence of specialist palliative care involvement. 7 (22%) received input whilst in hospital, 4 (13%) in the community. <h3>Conclusions</h3> The majority of our patients did not receive specialist palliative care support during the final stages of their disease. Whilst the majority (61%) of patients were functional class IV prior to death, 39% were functional class II or III. Progressive deterioration and increased burden of symptoms over time preceding death were commonly noted. Whilst the specialist PAH nurses and clinicians offer palliative care and support, our data suggests that a review of the timing, organisation and documentation of referral to specialist palliative care services requires consideration.
Abstract 2895: Effects of supplemental calcium and vitamin D3 on serum growth factors in sporadic colorectal adenoma patients in a randomized clinical trial
Authors: Joy R. Owen, Thomas Ahearn, Bill Liang, Veronika Fedriko, Jill Woodard, Roberd M. Bostick
Journal: Cancer Research (2010)

Abstract Fluctuations in energy homeostasis via perturbation of the intricate balance between nutritional intake, physical/energy expenditure, and genetics are thought to play a role in risk for colorectal neoplasms. Nutritional supplementation with calcium and vitamin D3 may ameliorate risk for colorectal neoplasms and help lead to the development of treatable, non-invasive biomarkers of risk for the disease. Basic science findings indicate that calcium and vitamin D affect the expression of growth factors, such as Insulin-like Growth Factor (IGF-1), but there have been no reports of investigations on the effects of calcium and vitamin D3 on growth factors in humans. We investigated the effects of calcium 2.0 g and/or vitamin D3 800 I.U. daily over six months on serum levels of IGF-1 and Insulin-like Growth Factor Binding Protein (IGFBP-3) in a pilot, randomized, double-blind, placebo-controlled, 2×2 factorial chemoprevention trial (n = 88) in sporadic colorectal adenoma patients. In the calcium relative to the placebo group, both IGF-1 (p = 0.08) and IGFBP-3 levels (p = 0.03) increased by 10%, whereas there was no evidence for treatment effects in the vitamin D3 group. In the calcium plus vitamin D3 relative to the placebo group, IGF-1 increased by 9% (p = 0.12) but there was no evidence for a change in IGFBP-3. These findings tentatively suggest that dietary supplementation with calcium and/or vitamin D3 may affect signal transduction pathways mediating the release of growth factors into the systemic circulation in humans and provide support for developing treatable, non-invasive biomarkers of risk for colorectal neoplasms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2895.
A2.12 Increased CXCR5 B cell expression, CXCL13 and SCD23 serum levels in untreated early rheumatoid arthritis patients support B cell activation since the initial phase of the disease
Authors: RA Moura, C Quaresma, AR Vieira, MJ Gonçalves, J Polido-Pereira, V Romão, N Martins, H Canhão, JE Fonseca
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background and objectives</h3> B-cells play several important roles in rheumatoid arthritis (RA) pathogenesis, namely through autoantibody production, antigen presentation and T cell activation, but few studies have been performed in untreated early RA patients. Therefore, the main goal of this study was to characterise B-cell phenotype and B-cell gene expression levels since early RA onset in comparison with the chronic phase of the disease. <h3>Materials and methods</h3> Blood samples were collected from untreated early RA (ERA) patients (&lt;1 year of disease duration), established RA patients under methotrexate treatment and age and sex-matched healthy donors. B-cell subpopulations were characterised by flow cytometry and B-cell gene expression was analysed by real-time PCR on isolated B-cells. Serum levels of BAFF, CXCL13 and sCD23 were determined by ELISA. <h3>Results</h3> The frequency of total CD19<sup>+</sup> B-cells in circulation was similar between controls and patients' groups, but established RA had significantly increased frequencies of double negative (IgD-CD27-) B-cells in comparison with controls. CXCR5 B-cell expression was significantly increased in both ERA and established RA in comparison with controls, but no significant differences were observed in BAFF-R, TACI, BCMA, CD69, CD86, HLA-DR, TLR9, CD95, IgM and CD5 B-cell expression between all groups analysed. Furthermore, alterations in B-cell gene expression levels were found in BAFF-R, TACI, TLR9, FcγRIIB, BCL-2, BLIMP-1 and β2M in ERA and established RA patients when compared to controls, but no significant differences were detected in AID, BCMA, CXCR5, TLR7 and TLR10 B-cell gene expression between all groups. In addition, CXCL13 and sCD23, but not BAFF serum levels, were significantly increased since early RA. <h3>Conclusions</h3> CXCR5 B-cell expression and CXCL13 serum levels are significantly increased in untreated early RA (&lt;1 year of disease duration) and established RA patients when compared to controls, which supports B-cell activation and recruitment to inflammatory sites since early disease onset. Alterations in B-cell gene expression levels increase with disease progression, particularly in BAFF- and toll-like receptors. The augmented sCD23 serum levels detected in ERA patients suggest that B-cell maturation occurs from early RA onset.
Unrecognized Renal Transplants as a Potential Source of False-Positive Interpretation of FDG PET
Authors: Liang Guan, Simin Dadparvar, Phillip Reich, Jian Qin Yu, Peeyush Bhargava, Abass Alavi, Hongming Zhuang
Journal: Clinical Nuclear Medicine (2003)

Renal transplantation has become an effective therapy for patients with late-stage renal disease. Fluorodeoxyglucose (FDG) positron emission tomography (PET) is accepted as an important diagnostic technique in the evaluation of suspected or known malignancies or other disorders in the day-to-day practice of medicine. Because FDG is excreted from the kidneys into the urine, unrecognized renal transplants can appear as malignant lesions. Familiarity with the clinical history is a prerequisite in the correct interpretation of FDG PET images in this setting. In addition, FDG PET images should be correlated with anatomic images when such studies are available. When neither clinical history nor anatomic images are available, a combination of "abnormal" activity in the pelvis and absence of normal renal activity should raise suspicion of the existence of a renal transplant.
AB1257-HPR Project to Develop Support Materials for Teaching and Training in Rheumatology Using Icts: Two Years of Experience at the Rheumatology Service of the Complexo Hospitalario Universitario de a Coruña
Authors: M. Freire, J. Gromaz, M. Diaz, E. Alonso, B. Aspe, A. Atanes, M. Bejerano, F. Blanco, J. Graña, C. Lopez, N. Oreiro, J. Pinto, F. De Toro
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The development of the internet and social media in everyday life has revolutionized the methods of data exchange as well as the search for information on the part of students and health professionals. Medical educators/teachers should not ignore this fact. <h3>Objectives</h3> To develop a reliable channel of informatiom To train health professionals in the learning of rheumatology exploration/research and basic knowledge of musculoskeletal diseases To develop a reliable channel of informatio <h3>Methods</h3> We have created a channel [of communication] - “CHUAC Rheumatology” - on the youtube webpage in order to upload and host teaching material. Illustrative videos of short duration have been recorded using an electronic tablet or camcorder. They have been edited with a very simple program. Two playlists have been created. The first one contains a whole set of videos on <i>exploration</i>, whereas the second one compiles basic lesson plans on rheumatology, including: Anatomical background aimed at improving the knowledge of rheumatic diseases, general principles of diagnosis - anamnesis, laboratory, radiology, management of osteoarthritis, back pain, osteoporotic vertebral fracture and knee arthrocentesis. <h3>Results</h3> The channel was created on January 14, 2013. There are 37 videos hosted. We have had 71,993 visits which amount a total of 3578 hours of viewing and a rate of average audience retention of 3 minutes on each visit. The main searching source is the web youtube (91%). The material has been seen mainly from Spain (40%) and Mexico (20%). We have 468 subscribers and we have received 303 messages of satisfaction (“Like”). If we analyze the five main locations of viewing, we come across a striking fact: in South America the material is mainly seen by students and health professionals that are between 18 and 34 years (between18 and 24 years (39-49%) and between 25-34 years (30-42%)). In Spain, however, the material is viewed and accessed in a fairly uniform way, from students that are 18 to adults that are 64 years old (15-16%), with an incidence peak between 25 and 34 (27%) and 45-54 (24%). In addition, the opinion of MIR students and of those who rotate around our service is very positive as they have teaching materials prior to rotation around our service. <h3>Conclusions</h3> In our opinion, this experience is useful to facilitate the learning of process of students and health professionals, and to improve the visibility of our hospital. The internet represents an important aid to support teaching and training needs and, therefore, we should make use of it. Furthermore, it is important to improve the digital skills aimed at teaching and training. <h3>Disclosure of Interest</h3> None declared
Chronic Discoid Lupus Erythematosus
Authors: Naomi Rothfield, Cyril H. March, Peter Miescher, Currier McEwen
Journal: New England Journal of Medicine (1963)

THE relation of chronic discoid lupus erythematosus to systemic lupus erythematosus has always been controversial. Studies reporting a frequent occurrence of clinical and laboratory abnormalities have led some authors to conclude that there is a high incidence of systemic involvement in patients with chronic discoid lupus and that the two diseases may represent different manifestations of the same conditio,.1 , 2 However, the lack of suitable control groups in these studies makes the data difficult to evaluate.To clarify this problem we have studied 65 patients with chronic discoid lupus erythematosus and 65 patients with other dermatologie disorders matched for age, sex . . .
Abstract 1778: Antitumor effect of PM01183 in a patient-derived Cisplatin-sensitive and -resistant serous epithelial ovarian orthotopic tumor model
Authors: Alberto Villanueva, August Vidal, M José Guillén, Ramón Salazar, Carmen Cuevas, Pablo M. Aviles
Journal: Cancer Research (2012)

Abstract Background: Epithelial ovarian cancer (EOC) is the leading cause of deaths in women diagnosed with gynecologic malignancies. The low survival rate is due to its advanced-stage diagnosis and either intrinsic or acquired resistance to standard platinum-based chemotherapy. As such, the development of effective innovative therapeutic strategies to overcoming cisplatin resistance remains a high priority. PM01183 is a new alkaloid that binds to the minor groove of DNA and induces delayed progression of S phase and cycle arrest in G2/M. Currently, PM01183 clinical development includes Phase II single agent trials (pancreas, breast and platinum-resistant/refractory ovarian) as well as Phase I trials in combination (with doxorubicin and gemcitabine) and in advanced acute leukemia. Here, we report that PM01183 is effective in the treatment of new developed orthotopic subject-derived epithelial serous ovarian tumor grafts Cisplatin-sensitive and-resitan models. Material and Methods: Athymic nude female mice were orthotopically engrafted with derived-fragments of OVAX1 (Cisplatin-Sensitive) or OVAX1R (Cisplatin-Resistant) tumors, and when tumors reached homogeneous palpable size were randomly allocated into the treatment groups (N = 8-12/group): i) Placebo; ii) PM01183 (0.18 mg/kg); iii) Cisplatin (3.5 mg/kg); and, iv) PM01183 plus Cisplatin (0.18+3.5 mg/kg). Drugs were intravenously administered once per week for 3 consecutive weeks (days 0, 7 and 14) and seven days after the last dose (Day 21), animals were sacrificed, their ovaries dissected-free and weighed. Statistical differences between groups were determined using two-tailed Mann-Whitney U test. Results: On day 21, OVA1X tumors experienced reductions of 95.3, 88.3 and 87.2% following the treatment with Cisplatin, PM01183 and PM01183+Cisplatin, respectively. The results obtained for OVA1XR tumor demonstrated tumor weight reductions of 48.2, 93.6 and 96.7% for Cisplatin, PM01183 and PM01183+Cisplatin treatments, respectively. Single therapy with PM01183 induced a statistically significant better response than Cisplatin (P=0.003). Also, PM01183+Cisplatin treatment increased the activity following Cisplatin (P=0.002) or PM01183 (P=0.022) administration as single agents, suggesting thus a synergistic effect of both compounds. Conclusions: PM01183 demonstrated strong in vivo antitumor activity in pure patient-derived Cisplatin-sensitive and Cisplatin-resistant serous epithelial ovarian orthotopic tumor models. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1778. doi:1538-7445.AM2012-1778
Abstract 2004: Search for biomarkers of oral lesion by laser microdissection and LC/MS/MS method
Authors: Gou Yamamoto, Chie Hokazono, Mao Kawamoto, Tomohide Isobe, Tarou Irie, Satoru Shintani, Tetsuhiko Tachikawa
Journal: Cancer Research (2010)

Abstract When we perform profiling analysis using tissue of Homo sapiens, individual difference becomes one of large problems. We use a laser microdissection as one of the solutions for this problem and try profiling analysis from tissue section. This technique can collect the part where morphologic evidence varies from the same tissue section, and comparison in an equivalence case besides in same lesion become possible. In addition, a laser microdissection method is effective in hyperplasia, papilloma, border domain, complicated differentiation form, such as lesion difficult to obtain a cultured cell. In this study, we collected area of normal epithelium, epithelial dysplasia and squamous cell carcinoma from tissue section by using laser microdissection. Collected tissue was dissolved in lysis buffer and digested by trypsin to make samples. Each sample was analyzed and quantified by LC/MS/MS, then, obtained data was referred to the protein database (SWISS PROT). From this procedure, we found over 100 different types of protein in every area. In comparison with each protein profiling list, many already known marker of oral squamous cell carcinoma, such as keratin 17, keratin 13, lumican and CD98, was detected. Two new candidate markers of oral squamous cell carcinoma are discovered at present: one is keratin superfamily, and another is tumor related protein. About extracted new candidate markers, we perform real time PCR, immunohistochemistry and Western blot from tissue section for validation. In conclusion, Laser microdissection and LC/MS/MS were useful method to search for markers of oral squamous cell carcinoma, and detected candidate marker was thought to be effective for diagnosis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2004.
Noninvasive Tests in the Initial Evaluation of Heart Murmurs in Children
Authors: Jane W. Newburger, Amnon Rosenthal, Roberta G. Williams, Kenneth Fellows, Olli S. Miettinen
Journal: New England Journal of Medicine (1983)

We prospectively examined the usefulness of electrocardiography, chest radiography, and M-mode echocardiography in discriminating between the presence and absence of heart disease in 280 children older than one month and newly referred for evaluation of a heart murmur. After taking a history and performing a physical examination but before reviewing diagnostic tests, we categorized the children as having "no heart disease" (142), "possible heart disease" (34), or "definite heart disease" (104). Among the children initially thought to have no heart disease, the diagnosis was changed after a review of diagnostic tests in eight--three with mitral-valve prolapse, two with possible cardiomyopathy, and three with no heart disease on follow-up. Among those initially thought to have possible heart disease, the tests changed the diagnosis to definite heart disease in four, of whom only one had heart disease (mitral-valve prolapse) on follow-up. In no case did a review of tests change the diagnosis of definite heart disease. We conclude that the results of diagnostic tests are unlikely to change the clinical diagnosis of no heart disease or definite heart disease, when made by a qualified pediatric cardiologist in children newly referred for evaluation of a heart murmur.
Chemotherapy Alone Compared with Chemotherapy plus Radiotherapy for Localized Intermediate- and High-Grade Non-Hodgkin's Lymphoma
Authors: Thomas P. Miller, Steve Dahlberg, J. Robert Cassady, David J. Adelstein, Catherine M. Spier, Thomas M. Grogan, Michael LeBlanc, Susan Carlin, Ellen Chase, Richard I. Fisher
Journal: New England Journal of Medicine (1998)

Patients with clinically localized, intermediate- or high-grade non-Hodgkin's lymphoma usually receive initial treatment with a doxorubicin-containing regimen such as cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). Pilot studies suggest that eight cycles of CHOP alone or three cycles of CHOP followed by involved-field radiotherapy are effective in such patients.