tbuckley/cabot-search huggingface dataset:
SP0023 Putting Knowledge into Practice: Psychological Barriers
Authors: V. Christodoulou
Journal: Annals of the Rheumatic Diseases (2014)

<h3></h3> Individuals living with chronic health conditions are often advised to adopt healthier lifestyles, including improving their nutrition. What is often disregarded by health professionals is that information-giving is often insufficient in supporting maintainable, substantial changes. Making long-term alterations to one9s lifestyle is challenging regardless of one9s circumstances. However, in the context of managing a chronic health condition one is faced with psychological barriers of a specific kind. Individuals with chronic health conditions may dislike being reminded of their physical difficulties, but adhering to a new 9healthier9 schedule means that one remains vigilant of daily choices and is consequently more aware of the underlying health condition. This awareness may result in undesirable emotional states such as sadness or anxiety that one might find difficult to handle. In an effort to then avoid, deny, or numb oneself from the worries or reminders of the chronic illness, it may become increasingly difficult to maintain a healthier lifestyle. The presentation will introduce mindfulness techniques for identifying and better handling undesirable thoughts, emotions and physical sensations that may act as barriers to healthier lifestyles. It will also discuss ways for initiating and maintaining internally motivated lifestyle changes though the activation of one9s personal values rather than acting on mandates of others such as family members or health professionals. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.6127
Carbon-Dioxide Intoxication in Emphysema: Emergency Treatment by Artificial Pneumoperitoneum
Authors: James J. Callaway, Victor A. McKusick
Journal: New England Journal of Medicine (1951)

WHEN oxygen is administered to a patient with chronic anoxemia, an elevation of the carbon-dioxide content and combining power of the blood usually occurs. In patients with marked pulmonary emphysema and fibrosis, this elevation is occasionally of profound degree, and a characteristic sequence of events ensues. The features of the clinical syndrome are headache, cutaneous vasodilatation, irrationality, stupor and coma. It is thought that these manifestations are due to carbon-dioxide intoxication. The chain of events leading to carbon-dioxide retention is believed to be as follows: removal of the anoxemic stimulus to respiration by the administered oxygen, reduced pulmonary ventilation, increase . . .
Abstract 4082: U6 upregulation in cancer
Authors: Larn Hwang, Xiaoqin Lin, Neil Desai, Vuong Trieu
Journal: Cancer Research (2010)

Abstract Background: U6 snRNA is a non-coding RNA that is a component of the splicesome, which is involved in RNA splicing of the pre-mRNA. In view of the critical function performed by U6 snRNA in RNA splicing and therefore cellular proliferation, it is possible that U6 would play a role in cancer development. In this study, U6 levels were examined across various tumor types. Methods: Detection of U6 snRNA in various normal and tumor tissue was performed with Tissue Microarray by In Situ Hybridization technique. The 5′-DIG-labeled U6 LNA probe (sequence 5′-CACGAATTTGCGTGTCATCCTT-3′) from Exiqon was used for this study and the Vector Red was used as substrate. The U6 stained tissue microarray was then scanned by GenePix 6.0 (Molecular Devices) at 532 nm to detect the staining intensity from each tissue sample. Each sample on the TMA was also visually scored by the intensity on a scale of 0 to 4. A quantitative real-time PCR assay was also used to confirm the overexpression of U6 snRNA in breast and other cancers. Results: A baseline study using tumor microarrays and visual scoring suggested that U6 snRNA levels were increased in tumors relative to normal tissues. This was confirmed using the rapid U6 snRNA ISH for colon carcinoma, melanoma, pancreatic carcinoma, renal carcinoma, and lung carcinoma. In all cases, U6 levels were significantly elevated in tumor versus normal by t-test. By RT-PCR, U6 snRNA levels were also found to be increased relative to the corresponding normal tissue in carcinoma of the breast, colon, kidney, liver, lung, and ovary. No increase over the corresponding normal tissue was found in prostate and thyroid carcinomas. In breast carcinoma, there was no correlation between U6 snRNA levels and estrogen receptor status, progesterone receptor status or erb-B2 expression levels. Conclusions: Using a scanning system and tumor tissue array, we were able to demonstrate the use of microarray scanner to quantitate ISH signal. Application of this technology to U6 snRNA demonstrated that U6 is significantly elevated in most cancer types examined. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4082.
P-284 Phase 3 RECOURSE trial of TAS-102 versus placebo with best supportive care in patients with metastatic colorectal cancer: European subgroup
Authors: A. Falcone, S. Laurent, C. Grávalos, M. Benavides, F. Longo Muñoz, M. Ychou, F. Ciardiello, S. Siena, K. Yamaguchi, K. Muro, T. Denda, Y. Tsuji, N. Tebbutt, P.J. Loehrer, H.-J. Lenz, R.J. Mayer, A. Ohtsu, E. Van Cutsem
Journal: Annals of Oncology (2015)
675 HIGH RESOLUTION-MAGIC ANGLE SPINNING (HRMAS)- NMR-BASED METABOLOMIC FINGERPRINTS OF EARLY AND RECURRENT HEPATOCELLULAR CARCINOMA
Authors: N. Culeddu, A. Solinas, M. Chessa, M.C. Porcu, G. Virgilio, F. Arcadu, A. Deplano, S. Cossu, D. Scanu, V. Migaleddu
Journal: Journal of Hepatology (2013)
OP0163 Predictors of Heart Rate Recovery following Exercise in Patients with Rheumatoid Arthritis
Authors: A. Osailan, G. Metsios, P. Rouse, J. Duda, N. Ntoumanis, G. Kitas, J.V. Zanten
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Cardiovascular disease (CVD) is a major cause of death in rheumatoid arthritis patients (RA). The underlying mechanisms for the CVD increase risk in RA are not fully understood. However, poor parasympathetic function, a risk factor for cardiac mortality in the general population, has been implicated in RA. Little is known about the predictors of parasympathetic function in RA, which is most commonly assessed by heart rate recovery following maximal exercise testing. <h3>Objectives</h3> To explore the association of multiple factors including traditional CVD risk factors, global CVD risk score, maximal oxygen uptake (VO<sub>2</sub>max), quality of life, and inflammatory markers with heart rate recovery (ΔHRR) following an exercise tolerance test, a marker of parasympathetic function. <h3>Methods</h3> 106 RA (54.5±12.3 years, 68% women) patients completed an exercise tolerance test on a treadmill, during which heart rate (HR) was monitored via 12 lead ECG. ΔHRR was quantified as the difference between maximal HR during exercise and HR one minute post exercise. Cardiorespiratory fitness (VO<sub>2</sub> max) was assessed via breath by breath gas analyses. A fasted blood sample was taken to examine levels of C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen and white blood cells (WBC), lipids profile, and markers of insulin sensitivity (HOMA, QUICKI). Quality of life was assessed using the EuroQol questionnaire.The Framingham Risk Score (FRS) was used as an assessment of global risk for CVD. <h3>Results</h3> The average drop in HRR was 29±13 beats per minute. Partial correlation (controlling for gender) analyses revealed that age (r = -0.25, p=0.03), resting HR (r = -0.34, p=0.003), triglycerides (r = -0.25, p=0.03), fibrinogen (r = -0.33, p=0.004), ESR (r = -0.24, p=0.03), WBC (r = -0.26, p=0.02), FRS (r = -0.28, p=0.01) were inversely associated with ΔHRR, whereas EuroQol (r =0.26, p=0.02) and VO<sub>2</sub> max (r =0.28, p=0.01) were positively associated with ΔHRR. To identify independent predictors of parasympathetic activity in RA, stepwise linear regression was conducted. This revealed that fibrinogen (p=0.03), resting HR (p=0.001), FRS (p=0.009) and EuroQol (p=0.01) were independently associated with ΔHRR. <h3>Conclusions</h3> Even though several individual CVD risk factors, such as inflammatory markers, fitness level, and quality of life were associated with parasympathetic activity, only fibrinogen, global CVD risk and quality of life were independently associated with parasympathetic activity in RA. These findings suggest that parasympathetic reactivation is predicted by overall CVD risk rather than individual risk factors. Longitudinal studies should explore how a reduction in CVD risk factors - achieved via exercise - may impact on parasympathetic activity in RA. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2884
Abstract 1949: Positive feedback regulation between EWS-FLI1 and miR-145 in Ewing's sarcoma
Authors: Jozef Ban, Pieter Mestdagh, Max Kauer, Gunhild Jug, Frank Speleman, Heinrich Kovar
Journal: Cancer Research (2010)

Abstract The EWS-FLI1 chimeric protein is a potent tumor specific transcriptional regulator and the molecular cause of Ewing's sarcoma family of tumors (ESFT). We had previously hypothesized that, since EWS-FLI1 is the major driver of aberrant gene expression in ESFT, there should be an inverse correlation between the changes in gene expression observed in ESFT cell lines in response to RNAi-mediated EWS-FLI1 knockdown and the corresponding gene expression in primary tumors relative to the tissue of origin. We found that mesenchymal progenitor cells (MPC) fit this assumption best and established an ESFT specific EWS-FLI1 transcriptional signature on the mRNA level. Following the same approach, we now studied the EWS-FLI1 dependent regulation of microRNAs (miRNAs) in ESFT. Genome-wide miRNA analysis was performed after shRNA-mediated stable (5 cell lines) and inducible (1 cell line) EWS-FLI1 knockdown, as well as in 6 primary ESFT and 6 MPC samples using the stem-loop reverse transcription quantitative PCR platform. Among miRNAs consistently affected by EWS-FLI1 silencing and inversely expressed in primary tumors compared to MPCs was hsa-miR-145 which we found upregulated upon EWS-FLI1 silencing. Since several target sites exist for this miRNA within the FLI1 3′UTR, we asked if hsa-miR-145 is capable of modulating EWS-FLI1 expression in ESFT cells. Upon ectopic expression of pri-miR-145 in wildtype p53 ESFT cells, strong modulation of EWS-FLI1 protein levels, but not RNA levels, was observed. In p53 mutant cell lines this effect was less pronounced consistent with a recently reported role of p53 in miR-145 maturation. Preliminary studies suggest that hsa-miR-145 is indirectly regulated by EWS-FLI1 by a mechanism that may involve the NOTCH signaling pathway. Our results identify a positive feed-back loop between EWS-FLI1 and hsa-miR-145 expression in ESFT. Supported by the 6th framework program of the European Commission, (STREP “E.E.T. Pipeline“ contract LSHC-CT-2006-037260) and grant P20665-B12 of the Austrian Science Fund FWF. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1949.
TCTAP A-167 Adherence to Evidence-Based Secondary Preventive Medications and Outcomes Assessments in Patients with Percutaneous Coronary Intervention Who Underwent Bare-Metal Versus Drug-Eluting Stenting
Authors: Shaban Mohammed, AbdulRahman Arabi, Ayman El-Menyar, Sabir Abdulkarim, Awad Al-Qahtani, Salah Salah Arafa, Amina Sadiq, Khalid Al Siyabi, Tarek Aboughazala, Jassim Al suwaidi
Journal: Journal of the American College of Cardiology (2015)
Fujinon Intelligent ChromoEndoscopy (FICE) et coloscopie haute définition dans la détection de la dysplasie chez les patients porteurs de rectocolite ulcéro hémorragique: une étude prospective comparative randomisée en cross over
Authors: G Vanbiervliet, J Filippi, A Desjeux, C Sakarovitch, N Lesavre Rosenzweig, S Garcia, MC Saint Paul, M Barthet, JC Grimaud, X Hébuterne
Journal: Endoscopy (2013)

L'exploration endoscopique la plus sensible pour le diagnostic des néoplasies recto coliques chez les patients atteints de rectocolite hémorragique (RCH) est controversée. Le système Fujinon Intelligent ChromoEndoscopie (FICE) est une technique endoscopique de coloration virtuelle permettant d'améliorer l'analyse du relief des muqueuses digestives. Le but de cette étude était de déterminer la précision diagnostique du système FICE comparée à l'endoscopie Haute Définition (HD) en lumière blanche pour la détection de la dysplasie recto colique chez les patients atteint de RCH.
Failure of Mefloquine Chemoprophylaxis for Malaria in Somalia
Authors: Alan J. Magill, Bonnie L. Smoak
Journal: New England Journal of Medicine (1993)

To the Editor: A weekly dose of 250 mg of mefloquine (Lariam) is being used by U.S. forces for chemoprophylaxis against malaria in Somalia. We report two cases of malaria caused by Plasmodium falciparum in U.S. soldiers who were taking mefloquine. A 23-year-old man was admitted on March 3, 1993, with a seven-day history of fever, chills, and headache. A blood smear showed P. falciparum. The serum mefloquine level in blood drawn when the patient's smear was positive was 1067 ng per milliliter for the parent compound and 4014 ng per milliliter for the primary metabolite. He had been taking . . .
ECHOCARDIOGRAPHY FAILS TO DETECT LEFT VENTRICULAR NON-COMPACTION IN A COHORT OF PATIENTS WITH NON-COMPACTION ON CARDIAC MAGNETIC RESONANCE IMAGING
Authors: Sachin V. Diwadkar, Leelakrishna Nallamshetty, Carlos Rojas, Matthew Schabath, Michael Fradley, Bengt Herweg, Sanders Chae
Journal: Journal of the American College of Cardiology (2015)
Mixed Infection With Simian Virus 40 and Adenovirus 12
Authors: Gregory T. O'Conor, Alan S. Rabson, Irene K. Berezesky, Frances J. Paul
Journal: JNCI Journal of the National Cancer Institute (1963)

Cultures of African green monkey kidney cells were infected simultaneously with simian vacuolating virus (SV40) and human adenovirus 12, two deoxyribonucleic acid viruses with oncogenic activity in Syrian hamsters. After 72 hours' incubation, the cells were studied with the electron microscope. Approximately 50 percent of the cells contained many virus particles morphologically typical of adenoviruses, with no evidence of SV40 particles. About 5 percent contained many SV40 particles but no adenovirus. In about 1 percent of the cells, however, large numbers of particles of both viruses, clearly differing in size and morphology, were intermingled within the same nucleus. When the inoculation of the cultures with adenovirus was delayed for 18.5 or 24 hours after the initial infection with SV40, the number of cells producing both viruses was substantially increased. But if the subsequent inoculation of adenovirus was withheld for 41 hours, a predominance of cells infected with SV40 alone was seen and only a relatively small percentage of cells containing both viruses was found. These observations indicate that mixed infection with SV40 and adenovirus 12 can occur and that variable degrees of partial exclusion may be produced.
LONG-TERM CLINICAL OUTCOME OF PATIENTS WITH ACUTE MYOCARDIAL INFARCTION COMPLICATED BY CARDIOGENIC SHOCK OR CARDIAC ARREST WHO RECEIVED EXTRACORPOREAL MEMBRANE OXYGENATION ASSISTED PRIMARY PERCUTANEOUS CORONARY INTERVENTION
Authors: Sung Won Cho, Jin Kun Jang, Sung Sik Kim, Seung Ho Kang
Journal: Journal of the American College of Cardiology (2015)
Abstract P4-12-06: A mammographic density prediction model using environmental factors, endogenous hormones and growth factors in Japanese women
Authors: N Yoshimoto, T Nishiyama, T Toyama, S Takahashi, N Shiraki, H Sugiura, Y Endo, M Iwasa, T Asano, Y Fujii, H Yamashita
Journal: Cancer Research (2012)

Abstract The incidence of breast cancer in Japanese women has doubled in all age groups over the past two decades, making it important to evaluate breast cancer risk factors in Japanese women. It is well known that mammographic density is positively associated with breast cancer risk in Western countries, and mammographic density is known to be affected by some environmental factors, serum hormones, and growth factors. We performed stepwise variable selection in a multiple regression model with fifteen independent variables as described below, based on the Akaike information criteria (AIC) to build a mammographic density prediction model using a dataset of 1191 women (913 women with breast cancer and 278 disease-free controls). The variables included were: environmental risk factors (body-mass index (BMI), age at menarche, pregnancy, age at first birth, breastfeeding, family history of breast cancer, age at menopause, use of hormone replacement therapy, alcohol intake and smoking), serum hormones and growth factors (estradiol, testosterone, prolactin, insulin-like growth factor 1 (IGF1) and IGF binding protein 3 (IGFBP3)) and mammographic density. The resulting prediction model is: Mammographic density = + 0.000476 (IGF1) −0.0605 (testosterone) − 0.0508 (IGFBP3) − 0.00683 (age) − 0.0175 (BMI) + 0.00883 (age at menarche) − 0.0153 (breast feeding), (R2 = 0.336). In this model, IGF1, testosterone, IGFBP3, age, BMI, age at menarche, and breastfeeding were considered to be important factors. IGF1 and age at menarche were positively associated with mammographic density, while on the other hand testosterone, IGFBP3, age, BMI, and breast feeding were negatively associated with mammographic density. Further studies are required to build a modified model incorporating serial measurements of serum hormones and growth factors to take into account time-dependent changes of serum hormones and growth factors, and to assess its accuracy. Citation Information: Cancer Res 2012;72(24 Suppl):Abstract nr P4-12-06.
Hepatic penetration by stomal ulcer: rare complication of a peptic ulcer
Authors: A. Oka, Y. Amano, Y. Uchida, K. Kagawa, Y. Tada, R. Kusunoki, N. Fukuba, I. Moriyama, T. Yuki, K. Kawashima, S. Ishihara, Y. Kinoshita
Journal: Endoscopy (2012)

A 57-year-old man, who had undergone a Billroth I partial gastrectomy for a duodenal ulcer 1 year previously, was hospitalized for continual epigastric pain over the past 1 month. Laboratory testing revealed anemia (hemoglobin 9.4 g/dL; normal range 13.5 – 16.9) and an elevated C-reactive protein level (2.22 mg/dL; normal < 0.02). Liver function tests and the serum gastrin level were within normal limits. Abdominal ultrasound revealed fluid and air bubbles in the liver ([Fig. 1 a]), moving between the liver and stomach through a fistula ([Fig. 1 b]). Computed tomography (CT) verified the ultrasound findings ([Fig. 2]). Endoscopy revealed a large ulcer in the duodenum near the anastomosis ([Fig. 3]). An endoscopic biopsy of the ulcer was negative for malignancy. The patient was diagnosed as having a stomal ulcer that had penetrated the liver, and he was subsequently treated with an H2 blocker and intravenous antibiotics. The ulcer healed after 1 month of treatment ([Fig. 4]). After discharge, the patient continued to take proton pump inhibitors (PPIs), and there has been no recurrence of the ulcer during the 7-year follow-up period.
THU0486-HPR Usefulness of touch-panel method for the evaluation of functional ability in rheumatoid arthritis
Authors: K. Kagawa, M. Kishimoto, E. Kudo-Tanaka, S. Tsuji, Y. Maeda, M. Yoshimura, A. Watanabe, Y. Harada, Y. Katada, M. Matsushita, J. Hashimoto, Y. Saeki, S. Ohshima
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In recent years, we have to evaluate the disease activity more precisely and more complexly in a tight schedule. Therefore we need the convenient system both for inputting the information and viewing the sufficient data. We developed an original computerized touch-panel type screening system for assessment of HAQ and visual analog scale (VAS). This is connecting to our original medical database for RA patients, called "MIRAI", MIRAI works as a supporting system for the electronic health record. It is possible to show the record of prescription for RA, DAS28, SDAI, CDAI, RAPID3, CRP, HAQ, map of swollen/tender joints and physician's VAS on the same screen. <h3>Objectives</h3> We assessed the usefulness of our original touch-panel method for the evaluation of functional ability in RA. <h3>Methods</h3> 300 RA patients visiting Osaka-Minami medical center were asked their opinion about their experience filling in the HAQ, their willingness for future registration on the touch-panel, and their opinion on usefulness of the HAQ in the survey questionnaire. <h3>Results</h3> The average age was 62.7 years (range 18-85) and 79% were female. The mean time patients needed to fill in their HAQ was 0.8 minutes (range 0.1-19.2). Inputting with touch-panel method was not time-consuming since it is easy to input and includes only a small number of actions. Result of survey questionnaires are presented in table 1. 96% of patients could fill out on the touch panel easily, and did not feel necessity of assistance at the next visit. 98.7% of patients were willing to fill in the HAQ at the next visit. All patients except one (99.7%) felt discussing problems in daily functioning is important, however it is not always discussed with the doctors (45.7%). 10.3% of patients felt HAQ did not give accurate representation of functional abilities. <h3>Conclusions</h3> This touch-panel method is very useful and feasible for assessing both the functional status quality of life and disease activity with rheumatoid arthritis. It might contribute to shortening the time of medical examination. In addition, MIRAI would be promising system for supporting the electronic health record. Furthermore, this system would develop the network efficiency among hospitals and consequently our clinical research collaboration as well. <h3>Disclosure of Interest</h3> None Declared
Formalin-induced severe colonic necrosis
Authors: S. Sallapant, P. Angsuwatcharakon, C. Thiptanakit, N. Wisedopas, R. Rerknimitr
Journal: Endoscopy (2013)

A 68-year-old woman with diabetes mellitus and end-stage renal disease developed recurring hematochezia after an endoscopic diathermy for diffuse angiodysplasia of the proximal colon. During the second colonoscopy, 100 mL of 1 % formalin was flushed through to ablate the angiodysplasia. After 2 days, the patient had another episode of hematochezia and was referred to our hospital. She was afebrile and denied abdominal pain. Complete blood count showed moderate anemia with mild leukocytosis. A third colonoscopy showed areas of well-demarcated, extensive necrosis starting at descending colon, and the scope was withdrawn without proximal colon examination ([Fig. 1]). Computed tomography (CT) of the abdomen showed arterial enhancing and thickening of the bowel wall, extending from the descending colon to the cecum. No pneumatosis intestinalis was detected ([Fig. 2]). Patient management included nil by mouth, intravenous fluids, and broad-spectrum antibiotics. On the fourth day after the formalin treatment, a follow-up CT scan demonstrated further extension of the colonic injury and the possibility of colonic perforation was considered. Consequently, the patient underwent total colectomy with ileorectal anastomosis, with no postoperative complications. Histopathological examination revealed mucosal sloughing, and a large area of hemorrhagic infarction of the mucosa and submucosa, without evidence of perforation ([Fig. 3]).