tbuckley/cabot-search huggingface dataset:
Supramolecular PEGylated Dendritic Systems as pH/Redox Dual-Responsive Theranostic Nanoplatforms for Platinum Drug Delivery and NIR Imaging
Authors: Yunkun Li, Yachao Li, Xiao Zhang, Xianghui Xu, Zhijun Zhang, Cheng Hu, Yiyan He, Zhongwei Gu
Journal: Theranostics (2016)

Recently, self-assembling small dendrimers into supramolecular dendritic systems offers an alternative strategy to develop multifunctional nanoplatforms for biomedical applications.We herein report a dual-responsive supramolecular PEGylated dendritic system for efficient platinum-based drug delivery and near-infrared (NIR) tracking.With a refined molecular/supramolecular engineering, supramolecular dendritic systems were stabilized by bioreducible disulfide bonds and endowed with NIR fluorescence probes, and PEGylated platinum derivatives coordinated onto the abundant peripheral groups of supramolecular dendritic templates to generate pH/redox dual-responsive theranostic supramolecular PEGylated dendritic systems (TSPDSs).TSPDSs markedly improved the pharmacokinetics and biodistribution of platinum-based drugs, owing to their stable nanostructures and PEGylated shells during the blood circulation.Tumor intracellular environment (low pH value and high glutathione concentration) could trigger the rapid disintegration of TSPDSs due to acid-labile coordination bonds and redox-cleavable disulfide linkages, and then platinum-based drugs were delivered into the nuclei to exert antitumor activity.In vivo antitumor treatments indicated TSPDSs not only provided high antitumor efficiency which was comparable to clinical cisplatin, but also reduced renal toxicity of platinum-based drugs.Moreover, NIR fluorescence of TSPDSs successfully visualized in vitro and in vivo fate of nanoplatforms and disclosed the intracellular platinum delivery and pharmacokinetics.These results confirm tailor-made supramolecular dendritic system with sophisticated nanostructure and excellent performance is a promising candidate as smart theranostic nanoplatforms.
The dexamethasone suppression test in organic affective syndrome
Authors: D L Evans, C B Nemeroff
Journal: American Journal of Psychiatry (1984)

Of six patients with a DSM-III diagnosis of organic affective syndrome, four exhibited cortisol nonsuppression on the dexamethasone suppression test (DST). Three nonsuppressors were retested after successful treatment and before discharge; two had normal DSTs, and the other patient's DST normalized after discharge.
PCM-08<i>IN VIVO</i>MAGNETIC RESONANCE IMAGING IDENTIFIES CLINICAL PHENOTYPES OF PAEDIATRIC GLIOBLASTOMA IN AN ORTHOTOPIC MOUSE XENOGRAFT MODEL
Authors: Mariama Fofana, Jessica K. R. Boult, Maria Vinci, Valeria Molinari, Sergey Popov, Alan Mackay, Angel M. Carcaboso, Chris Jones, Simon P. Robinson
Journal: Neuro-Oncology (2016)
A Phase 1/2 Study Of Bosutinib (SKI-606) In Japanese Adults With Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia (CML)
Authors: Naoto Takahashi, Kenichi Ishizawa, Chiaki Nakaseko, Yukio Kobayashi, Kazuteru Ohashi, Yasunori Nakagawa, Kazuhito Yamamoto, Koichi Miyamura, Masafumi Taniwaki, Masaya Okada, Tatsuya Kawaguchi, Atsushi Shibata, Yosuke Fujii, Chiho Ono, Kazunori Ohnishi
Journal: Blood (2013)
What is the ideal ablation therapy for Barrett’s esophagus?
Authors: Raf Bisschops
Journal: Endoscopy (2015)

Over the past decade, endoscopic resection of early mucosal neoplasia with subsequent ablation of the remainder of the Barrett’s epithelium has replaced subtotal esophagectomy as the first-line treatment for early mucosal Barrett’s-associated neoplasia. Endoscopic resection has been shown to be oncologically safe and comparable to surgery [1]. However, metachronous lesions develop in up to 30 % of patients, and therefore a two-step approach involving the removal of all visible neoplasia followed by ablation of the remaining Barrett’s mucosa is adopted in order to reduce this risk significantly [2].
A Clinical study on activity of NAMPT and SIRT1 gene expression in neutropenia with cancer chemotherapy
Authors: Yukari Tsubata, Mika Nakao, Tamio Okimoto, Akihisa Sutani, Hiromitsu Karube, Michiko Horiguchi, Chikamasa Yamashita, Hiroshi Ohtsu, Takeshi Isobe
Journal: Annals of Oncology (2015)
Soundings: No more bed blocking
Authors: Colin Douglas
Journal: BMJ (2002)

Here in the Greater Auchendreich Health Board area—where recent reorganisation has brought together primary care and acute services, along with strong and welcome board-level input from our colleagues in the world of social work—bed-blocking is no more.

Instead it is called delayed discharge, but despite the welcome advance in nomenclature the statistics remain depressingly familiar. Already cynics are muttering that our latest reorganisation can do little to address one of the central issues faced by all major healthcare providers in Auchendreich today.

Such pessimism was confounded at a major workshop, “Tackling Delayed Discharge: Towards a Whole-Auchendreich Approach,” held last Friday in the Auchendreich Hilton (formerly the Dreichmuir Station Hotel). It featured strong inter-agency, multidisciplinary, and public/private participation, and what made the day so special was something quite new to us here in Auchendreich: high-level event-facilitation expertise.

A small lady in large pink glasses—one of a London team who had braved the B7023 shortly after the worst snowstorm of the winter—began by explaining that, of course, only us folks here on the ground could solve the little problem we had probly kinda gotten to thinking of as a great big problem. But she and her team would help us find the strength and the tools to do a truly wonderful job.

After coffee, a few unlucky souls were singled out to stand up and say how they really felt about the problem. Real negative feelings, our facilitator explained, were OK. One of our most junior social workers even shed a tear or two. A briefing for the breakout sessions followed, the key to their success being the use of sticky notelets (“Yellow for happy thoughts, blue for bad thoughts—y'all know about the blues?”). An orthopod looked puzzled.

Over lunch a few disenchanted souls commented adversely on the morning's work, speculating that even Blue Peter and Billy Graham himself, working in perfect harmony, might not be quite up to solving bed blocking in Auchendreich.

The afternoon session was significantly less well attended, so at five to three Sir Hector—who has surprised even himself by surviving as our board chairman—closed the meeting and wished our guests a swift journey back to London, despite worrying news of further snowfalls, with drifting, on the B7023.
Disturbed canonical nuclear factor of κ light chain signaling in B cells of patients with common variable immunodeficiency
Authors: Baerbel Keller, Zoltan Cseresnyes, Ina Stumpf, Claudia Wehr, Manfred Fliegauf, Alla Bulashevska, Susanne Usadel, Bodo Grimbacher, Marta Rizzi, Hermann Eibel, Raluca Niesner, Klaus Warnatz
Journal: Journal of Allergy and Clinical Immunology (2016)
Abstract 12088: cMyBP-C’S Interaction With Actin is Critical to Maintain Diastolic Function in vivo
Authors: Md. Shenuarin Bhuiyan, Jeanne James, Hanna Osinska, James Gulick, John N. Lorenz, Jeffrey Robbins
Journal: Circulation (2014)

Background: cMyBPC’s interaction with actin is critical to maintain diastolic function in vivo Rationale: Extensive studies demonstrate that cardiac myosin binding protein C (cMyBP-C) is a critical mediator of diastolic function through its interaction with actin, myosin and titin. The precise molecular mechanisms underlying the protein’s function remain elusive as cMyBP-C’s structural domains responsible for actin and/or myosin interaction are ill-defined and the physiological consequences of these filament interactions are unknown. Objective: In the present study, we made transgenic mice that lacked cMyBP-C’s actin and/or the head region of the myosin heavy chain (S2-MyHC) sites in order to better understand the molecular mechanisms of cMyBPC-mediated regulation of cardiac contraction, particularly diastolic function. Methods and Results: Using a combination of genetics and functional assays, we defined cMyBP-C’s N-terminal structural domains as well as the critical residues necessary or sufficient to mediate interactions with actin and/or S2-MyHC. Using genetic experiments, we first confirmed that mutation of three lysines to alanines in the C1 domain abolished actin binding (cMyBP-C Act- ). Similarly, mutation of three arginines to alanines in the “m” domain abolished S2-MyHC binding (cMyBP-C S2- ). To determine the functional roles of these sites in vivo, we generated transgenic lines in which normal cMyBP-C was replaced by either cMyBP-C Act-,S2- or wild type (cMyBP-C WT ), transgenically-encoded cMyBP-C. Mutant protein was completely substituted for endogenous cMyBP-C by breeding the transgenes into a cMyBP-C null background. The cMyBP-C Act-,S2- mice developed significant cardiac hypertrophy with myofibrillar disarray and fibrosis. Echocardiographic Doppler measurements showed that cMyBP-C Act-,S2- mice develop both diastolic and systolic dysfunction. In contrast, the cMyBP-C WT Tg line showed normal cardiac structure and function. Conclusions: These results suggest that the cMyBP-C’s interactions with both actin/S2-MyHC are structurally important to preserve normal cardiac contractility and particularly, cMyBP-C’s interaction with actin is indispensable for normal diastolic function.
HG-71ULTRA-SENSITIVE DETECTION OF HOTSPOT MUTATIONS IN PEDIATRIC THALAMIC TUMOURS TO REVEAL NEGATIVE PROGNOSTIC MARKERS
Authors: Scott Ryall, Anthony Arnoldo, Pawel Buczkowicz, Matthew Mistry, Rahul Krishnatry, Josh Rubin, Paul Steinbok, Uri Tabori, Cynthia Hawkins
Journal: Neuro-Oncology (2016)
EPI-09SYSTEMATIC LITERATURE REVIEW TO STUDY SYMPTOMATOLOGY AND POPULATION BASED TOTAL DIAGNOSTIC INTERVAL (TDI) OF CHILDREN PRESENTING WITH BRAIN TUMOURS: EVIDENCE TO UPDATE AND EVALUATE THE ROYAL COLLEGE OF PAEDIATRICS AND CHILD HEALTH (RCPCH) CLINICAL GUIDANCE, THE FOCUS FOR THE HEADSMART BE BRAIN TUMOUR AWARE CAMPAIGN (WWW.HEADSMART.ORG.UK)
Authors: Dhurgshaarna Shanmugavadivel, Jo-Fen Liu, Laura Murphy, Sophie Wilne, David Walker
Journal: Neuro-Oncology (2016)
EPN-20NEWLY DIAGNOSED METASTATIC INTRACRANIAL EPENDYMOMA IN CHILDREN: FREQUENCY, TREATMENT AND OUTCOME IN THE POPULATION BASED, PROSPECTIVE HIT-SERIES
Authors: Martin Benesch, Martin Mynarek, Klaus Müller, Monika Warmuth-Metz, Torsten Pietsch, Stefan M. Pfister, Hendrik Witt, Gudrun Fleischhack, Irene Schmid, Christof Kramm, Peter Vorwerk, Andreas Beilken, Carl Friedrich Classen, Pablo Hernáiz Driever, Gabriele Kropshofer, Thomas Imschweiler, Björn-Ole Juhnke, Rolf-Dieter Kortmann, Stefan Rutkowski, Katja von Hoff
Journal: Neuro-Oncology (2016)
A Unique Translocation of the TEL Gene in a Case of Acute Myelogenous Leukemia With inv(12)(p13q15)
Authors: Misao Setoyama, Arinobu Tojo, Fumitaka Nagamura, Shigetaka Asano, Minenori Ishimae, Mariko Eguchi, Nanao Kamada
Journal: Blood (1998)
Cystic Fibrosis
Authors: Barbara H. Bowman, John A. Mangos
Journal: New England Journal of Medicine (1976)

Cystic fibrosis was described as a specific entity in 1936. The failure to recognize it before then was a consequence of the fact that the clinical manifestations are common to many other disorders in infancy. Andersen, at Columbia University, and Fanconi, in Italy, independently described the characteristic clinical findings of cystic fibrosis — that is, pulmonary disease and malnutrition. They also studied the morphologic abnormalities found in the pancreas and lungs on autopsy of infants who died of the disorder. The onset and course of the disease appeared to be uniform; infection of the respiratory system or diarrhea with failure . . .
Dexamethasone suppression tests in patients with obsessive-compulsive disorder
Authors: J A Lieberman, J M Kane, S Sarantakos, K Cole, A Howard, M Borenstein, H Novacenko, J Puig-Antich
Journal: American Journal of Psychiatry (1985)

Obsessive-compulsive disorder and major depressive disorder are associated by several lines of evidence. To explore the possible relationship between the two disorders, the authors administered 1-mg dexamethasone suppression tests to 18 patients with obsessive-compulsive disorder and 51 patients with major depressive disorder. None of the obsessive-compulsive patients were classified as nonsuppressors on the basis of a 4:00 p.m. serum cortisol level, whereas 37% of the depressed patients were nonsuppressors. The mean cortisol levels of the two groups differed significantly. Factors that may influence hypothalamic-pituitary-adrenal function, such as age, depressive symptoms, and severity of illness, are discussed in light of these results.
CMS-09BEHAVIOR AND TEMPERAMENT IN CHILDREN TREATED FOR PEDIATRIC MEDULLOBLASTOMA WITH POSTOPERATIVE CEREBELLAR MUTISM SYNDROME
Authors: Nicole Law, Iska Moxon-Emre, Eric Bouffet, Michael D. Taylor, Ute Bartels, Nadia Scantlebury, Caelyn Kaise, Donald Mabbott
Journal: Neuro-Oncology (2016)
Abstract 16444: Real-Time Assessment of Vascular Access Complications
Authors: Christopher Arevalos, Alireza Nazeri, Joel Khan, Marissa Brower, Andy Chang, Thomas Segall-Shapiro, Maria Oden, Mehdi Razavi
Journal: Circulation (2011)

Background: Vascular access (VA) can lead to bleeding complications at the VA site. We tested the hypothesis that impedance changes from electrodes embedded within a standard sheath can predict per...
Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock, 2012
Authors: R. P. Dellinger, Mitchell M. Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M. Opal, Jonathan E. Sevransky, Charles L. Sprung, Ivor S. Douglas, Roman Jaeschke, Tiffany M. Osborn, Mark E. Nunnally, Sean R. Townsend, Konrad Reinhart, Ruth M. Kleinpell, Derek C. Angus, Clifford S. Deutschman, Flavia R. Machado, Gordon D. Rubenfeld, Steven Webb, Richard J. Beale, Jean-Louis Vincent, Rui Moreno
Journal: Intensive Care Medicine (2013)
Disability and depressive symptoms in two communities
Authors: T J Craig, P A Van Natta
Journal: American Journal of Psychiatry (1983)

A community survey conducted in Kansas City, Mo., and Washington County, Md., revealed a significant association between symptoms of depression and self-reported disability. No demographic variables showed any consistent relationship to disability. The findings underscore the need for programs designed to identify and treat depression. In addition, any study using disability as an outcome measure must control for level of depressive symptoms.
OBSTRUCTIVE BILIARY CIRRHOSIS.
Authors:  STERNBERG,  PHILLIPSBORN
Journal: JAMA (1901)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Hypersensitivity reactions to teniposide in children.
Authors: H Carstensen, H Nolte, H Hertz, T Jensen
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.9.1491 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3625264 Hypersensitivity reactions to teniposide in children. H CarstensenxH CarstensenSearch for articles by this author , H NoltexH NolteSearch for articles by this author , H HertzxH HertzSearch for articles by this author , T JensenxT JensenSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.9.1491 PDF "Hypersensitivity reactions to teniposide in children.." Journal of Clinical Oncology, 5(9), pp. 1491–1492© 1987 by American Society of Clinical Oncology
MB-92DO ABCB1 EXPRESSING DRUG RESISTANT CANCER STEM CELLS UNDERLIE MEDULLOBLASTOMA METASTASIS?
Authors: Aishah Nasir, Ramadhan T. Othman, Delyan P. Ivanov, Lisa Storer, David Onion, Audrey Korshunov, Stefan M. Pfister, Ian D. Kerr, Anna Grabowska, Beth Coyle
Journal: Neuro-Oncology (2016)
CSF gamma-aminobutyric acid in alcoholics and control subjects
Authors: A Roy, J DeJong, T Ferraro, B Adinoff, B Ravitz, M Linnoila
Journal: American Journal of Psychiatry (1990)

Alcohol has widespread effects on the gamma-aminobutyric acid (GABA) system in the brain. This system in the brain is also postulated to have a role in anxiety, and alcoholics have been reported to have more anxiety disorders. Therefore, the authors undertook a study to compare CSF levels of GABA in abstinent alcoholic patients and normal control subjects. There was no significant difference between groups in CSF levels of GABA. Also, there was no significant difference in GABA level between alcoholic patients with histories of withdrawal seizures and those without such a history.
Increase in coronary atherosclerosis severity and the prevalence of coronary artery mixed plaques in patients with psoriasis
Authors: R. Bissonnette, F. Cademartiti, E. Maffei, J.-C. Tardif
Journal: British Journal of Dermatology (2016)

Psoriasis is a chronic immune-mediated disease with a prevalence as high as 3%. Several studies have reported that psoriasis is an independent risk factor for myocardial infarction, however some studies failed to show an increased risk of myocardial infarction in patients with psoriasis and the subject remains controversial.

This article is protected by copyright. All rights reserved.
A Unique Serum Protein in Mice With Various Tumors2
Authors: Winifred G.- Palmer, Thomas W. Orme, Charles W. Boone
Journal: JNCI Journal of the National Cancer Institute (1974)

A unique serum protein, visible on polyacrylamide gels, was observed in mice with 10 types of tumors. Detection of this tumor-bearer serum protein was facilitated by partial immunosorption with antiserum to normal mouse serum before electrophoresis.
Soundings: What does the patient want?
Authors: Liam Farrell
Journal: BMJ (2003)

“What made you suspicious, Farrell?”

Holmes was a trifle unimaginative, but he was a stout fellow and well worth his keep, as the big problem with a meritocracy is that good servants are hard to find; when everybody's somebody, then nobody's anybody.

“It was the curious incident of the cough in the night,” I said.

“But the patient did not cough in the night,” said Holmes.

“Exactly,” I said, “and that was the curious incident.”

A symptom's absence may sometimes be as telling as its presence. Joe was an almost daily attender, could never leave without a prescription, and had as many symptoms as there are stars in the sky, so when he said he had yet another headache I was not overly concerned. He had nausea and vomiting, yet was the headache worse in the morning and on leaning forward? Of course. Had he double vision? No. And I heard a cock crow three times. For Joe to deny a symptom was as rare as somebody who declares war and actually takes part in it.


His ears grew longer and even hairier


After 20 years in practice, I'm hard to shock, so I was only mildly surprised when his skin suddenly turned a bilious green, his ears grew longer and even hairier, and antennae sprouted from his head, all of which actually improved his appearance. “I am an emissary from the planet Zarg,” he said, his voice sibilant and his breath pungent yet noxious, his forked tongue dripping acid saliva on my foot. “Our beloved Emperor Peebo has been most gravely ill for many years and I have long been seeking a physician both wise and intuitive who might provide a cure for this distressing malady. If you succeed you shall be deemed Lord of all Doctors in the Universe and our two peoples shall abide in everlasting friendship.”

“What are his Majesty's symptoms?” I asked.

“He has a sore throat and has been bringing up horrible green phlegm.”

“Gosh, Joe,” I said, “the things you'll do to get an antibiotic.”
Erratum to: Variation in 5-hydroxymethylcytosine across human cortex and cerebellum
Authors: Katie Lunnon, Eilis Hannon, Rebecca G.Smith, Emma Dempster, Chloe Wong, Joe Burrage, Claire Troakes, Safa Al-Sarraj, Agnieszka Kepa, Leonard Schalkwyk, Jonathan Mill
Journal: Genome biology (2016)

After the publication of this work [1] it was noticed that the GEO accession number in the data availability section was incorrect. This has now been corrected in the original version of this paper.
Peer Review of Group Therapy: Washington, D.C., 1972–1977
Authors: Martin G. Allen
Journal: American Journal of Psychiatry (1979)

The author discusses the evolution of psychiatric peer review in Washington, D.C. In its first six years (1972-1977) the Washington Psychiatric Society Peer Review Committee evaluated 146 cases, 23 (16%) of which focused on group therapy. Eight of these cases (35%) were partially or fully denied. Most of the cases involved outpatients with neuroses or character disorders who were treated in combined group and individual therapy. The author presents specific cases illustrating group therapy issues and peer review decisions. He discusses the benefits and liabilities of peer review and emphasizes its importance as a flexible, clinically sensitive, confidential, and meaningful process.
Influences of Heredity and the Mammary Tumor Agent on the Occurrence of Mammary Tumors in Hybrid Mice
Authors: Howard B. Andervont, Thelma B. Dunn
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article Influences of Heredity and the Mammary Tumor Agent on the Occurrence of Mammary Tumors in Hybrid Mice Get access Howard B. Andervont, Howard B. Andervont Search for other works by this author on: Oxford Academic PubMed Google Scholar Thelma B. Dunn Thelma B. Dunn Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 2, October 1953, Pages 317–327, https://doi.org/10.1093/jnci/14.2.317 Published: 01 October 1953 Article history Received: 28 May 1953 Published: 01 October 1953