tbuckley/cabot-search huggingface dataset:
Abstract A39: FOXO1 is a key determinant of progesterone receptor isoform-specific senescence programming in ovarian cancer cells.
Authors: Caroline H. Diep, Todd P. Knutson, Laura J. Mauro, Carol A. Lange
Journal: Clinical Cancer Research (2016)

Abstract Progesterone promotes proliferation and pro-survival in the breast, but inhibits growth in the reproductive tract and ovaries. Herein, using progesterone receptor (PR) isoform-specific ovarian cancer models, we show that PR-A and PR-B promote expression of distinct gene sets that differ from PR-driven genes in breast cancer cells. In ovarian cancer models, PR-A primarily regulates genes independently of progestin, while PR-B is the dominant ligand-dependent isoform. Notably, FOXO1 and the PR/FOXO1 target-gene p21 are repressed by PR-A, but induced by PR-B. In the presence of progestin, PR-B, but not PR-A, robustly induced cellular senescence via FOXO1-dependent induction of p21 and p15. ChIP assays performed on PR-isoform specific cells demonstrated that while each isoform is recruited to the same PRE-containing region of the p21 promoter in response to progestin, only PR-B elicits active chromatin. Overexpression of constitutively active FOXO1 (FOXO1-AAA) in PR-A-only expressing cells conferred robust ligand-dependent upregulation of the PR-B-target genes GZMA, IGFBP1, and p21, and induced cellular senescence. Similar results were observed when PR-A was titrated into PR-B-containing cells. PR isoform-specific regulation of the FOXO1/p21 axis recapitulated in human primary ovarian tumor explants treated with progestin. Our data indicate a key requirement for FOXO1 (a PR-B-induced, but PR-A-repressed gene) in progesterone signaling to cellular senescence in ovarian cancer cells and reveal a novel mechanism for PR-target gene (FOXO1) control of hormone sensitivity. Ultimately, harnessing PR isoform-specific gene regulation in hormone-driven cancers may provide a means to therapeutically induce the protective actions of progesterone while blocking unwanted proliferative and pro-survival effects. Citation Format: Caroline H. Diep, Todd P. Knutson, Laura J. Mauro, Carol A. Lange. FOXO1 is a key determinant of progesterone receptor isoform-specific senescence programming in ovarian cancer cells. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr A39.
Case 3-1991
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, William F. McNeely, Betty U. McNeely, Susan S. Baker, Carolyn C. Compton
Journal: New England Journal of Medicine (1991)

Presentation of CaseA 17-year-old boy was admitted to the hospital because of autoimmune hemolytic anemia and a question of chronic active hepatitis.The patient was well until 14 months earlier, when symptoms of an upper respiratory tract infection developed, with a lingering cough; jaundice and fatigue soon followed. Evaluation at this hospital three weeks later showed sallow skin and icteric sclerae; the liver and spleen were not felt. There was no history of chills, fever, pruritus, weight loss, nausea, vomiting, diarrhea, recent travel, or exposure to toxic materials. The patient's mother gave a history of thalassemia minor. There was . . .
Three new treatments for diabetes recommended by NICE
Authors: Ingrid Torjesen
Journal: BMJ (2016)

The National Institute for Health and Care Excellence (NICE) has published final guidance recommending three drugs—canagliflozin (Invokana), dapagliflozin (Forxiga), and empagliflozin (Jardiance)—as treatment options for adults with type 2 diabetes if metformin, sulfonylurea, or pioglitazone are contraindicated or not tolerated.1

The three drugs could be used …
Sequencing-Based Detection of Minimal Residual Disease Is Associated with Outcomes after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Lymphoid Malignancies
Authors: Alex F Herrera, Haesook T. Kim, Malek Faham, Heather Sun, Aliyah R Sohani, Edwin P Alyea, Yi-Bin Chen, Corey S Cutler, Vincent T Ho, John Koreth, Sarah Nikiforow, Jerome Ritz, Scott J Rodig, Robert J Soiffer, Joseph H Antin, Philippe Armand
Journal: Blood (2014)
Epidemiological and clinical characteristics of patients infected with enterovirus D68, France, July to December 2014
Authors: Isabelle Schuffenecker, Audrey Mirand, Laurence Josset, Cécile Henquell, Denise Hecquet, Léa Pilorgé, Joëlle Petitjean-Lecherbonnier, Catherine Manoha, Jérôme Legoff, Claire Deback, Sylvie Pillet, Quentin Lepiller, Jean Michel Mansuy, Stéphanie Marque-Juillet, Denise Antona, Hélène Peigue-Lafeuille, Bruno Lina
Journal: Eurosurveillance (2016)

In 2014, the United States (US) experienced a nationwide outbreak of enterovirus D68 (EV-D68) infection with 1,152 cases reported mainly in hospitalised children with severe asthma or bronchiolitis. Following the US alert, 11 laboratories of the French enterovirus (EV) surveillance network participated in an EV-D68 survey. A total of 6,229 respiratory samples, collected from 1 July to 31 December 2014, were screened for EV-D68 resulting in 212 EV-D68-positive samples. These 212 samples corresponded to 200 EV-D68 cases. The overall EV-D68 positivity rates among respiratory samples were of 5% (184/3,645) and 1.1% (28/2,584) in hospitalised children and adults respectively. The maximum weekly EV-D68 positivity rates were of 16.1% for children (n = 24/149; week 43) and 2.6% for adults (n = 3/115; week 42). Of 173 children with EV-D68 infection alone, the main symptoms were asthma (n = 83; 48.0%) and bronchiolitis (n = 37; 21.4%). One child developed acute flaccid paralysis (AFP) following EV-D68-associated pneumonia. Although there was no significant increase in severe respiratory tract infections reported to the French public health authorities, 10.7% (19/177) of the EV-D68 infected children and 14.3% (3/21) of the EV-D68 infected adults were hospitalised in intensive care units. Phylogenetic analysis of the viral protein 1 (VP1) sequences of 179 EV-D68 cases, revealed that 117 sequences (65.4%), including that of the case of AFP, belonged to the B2 variant of clade B viruses. Continuous surveillance of EV-D68 infections is warranted and could benefit from existing influenza-like illness and EV surveillance networks.
Case 13-1980
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Simeon Locke, Edward P. Richardson, Eugene J. Mark
Journal: New England Journal of Medicine (1980)

Presentation of CaseA 56-year-old woman was admitted to the hospital because of a neurologic disorder.Five years previously she entered another hospital because of dyspnea. Microscopical examination of an open-lung-biopsy specimen was reported to show lymphocytic interstitial pneumonitis. Prednisone was prescribed in a dose of 30 mg daily. Two years before admission digoxin was added. During the year before entry the dyspnea worsened, and the patient was admitted twice to a second hospital. Prednisone and digoxin were continued, and furosemide was added. Five months before admission continuous oxygen therapy at home was initiated. Two months later pulmonary-function studies revealed . . .
Modern love
Authors: Theodore Dalrymple
Journal: BMJ (2008)

When I was a senior house officer, in those happy, distant days before the Reform of the Reorganisation of the Reform of the Reorganisation of the Reform of the Reorganization of the NHS, I had a colleague who, in her spare time, wrote hospital romances. She produced four of them a year under a pseudonym that she would not reveal to the rest of us, and was reputed by this means to earn £15 000 a year, which was a small fortune at the time.
Call to cancel 2016 Olympics because of Zika risk is not backed by WHO guidance
Authors: Rebecca Coombes
Journal: BMJ (2016)

A call by a leading public health expert to cancel this summer’s Olympic Games in Brazil for fear of accelerating a global spread of the Zika virus has been quelled by new World Health Organization guidance, which backs travel but advises athletes and visitors to take simple steps to manage health risks.

Writing in the Harvard Public Health Review this month,1 Amir Attaran, professor in the faculties of law and medicine at the University of Ottawa in Canada, described Rio de Janeiro as being at the “heart” of the current Zika epidemic and said that the Olympic organisers must confront “the bitter truth: the 2016 Olympic …
Construction of A Non-Redundant Human SH2 Domain Database
Authors: Haiming Huang, Yuchen Jiao, Rui Xu, Youhe Gao
Journal: Genomics Proteomics & Bioinformatics (2004)

Abstract Domain database is essential for domain property research. Eliminating redundant information in database query is very important for database quality. Here we report the manual construction of a non-redundant human SH2 domain database. There are 119 human SH2 domains in 110 SH2-containing proteins. Human SH2s were aligned with ClustalX, and a homologous tree was generated. In this tree, proteins with similar known function were classified into the same group. Some proteins in the same group have been reported to have similar binding motifs experimentally. The tree might provide clues about possible functions of hypothetical proteins for further experimental verification.
Hepatobiliary scintigraphy in an exacerbation of Dubin-Johnson syndrome.
Authors: ANDREW MEHOLIC, JEFFREY HOUSTON
Journal: Clinical Nuclear Medicine (2001)

From the Department of Radiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico Received for publication October 18, 2000. Accepted November 15, 2000. Reprint requests: Andrew J. Meholic, Department of Radiology (UNMH 1-West), University of New Mexico Health Sciences Center, 915 Camino de Salud NE, Albuquerque, New Mexico 87131-5336.
Risk factors for low-grade neuroendocrine carcinoma (LGNET): Hospital-based case-control study in US
Authors: M. Hassan, C. Dagohoy, C. Leary, D. Li, J. C. Yao
Journal: Journal of Clinical Oncology (2007)

4641 Background: There has been an increase in the diagnosed incidence of LGNET in US over the last 2 decades. Little is known about the etiology of LGNET. In this hospital-based, case-control study we evaluated the association of cigarette smoking, alcohol consumption, diabetes mellitus (DM) and family history of cancers with LGNET of different sites. Method: Cases were patients with LGNET referred to The University of Texas M.D. Anderson Cancer Center between 12/1999 and 9/2005. Controls were selected from healthy individuals who accompanied patients with other cancers. Logistic regression was applied to estimate the adjusted odds ratio (AOR) and 95% confidence interval (CI) for potential risk factors and demographic characteristics. Result: We identified 951 LGNET patients with primary sites including appendix (n=102, 10.7%), small bowel (n=234, 24.6%), lung (n=149, 15.7%), pancreas (n=166, 17.5%), stomach (n=55, 5.8%), rectum (n=56, 5.9%), and others (n=189, 19.2%). Cases were compared to 924 controls. Majority of subjects were white-race (cases, 79.7%; controls, 89.5%). Gender distribution was similar in LGNET patients with 1:1 ratio. DM was associated with pancreatic and gastric primary sites; AOR and 95% CI were 2.5 (1.6–3.9) and 4.5 (2.2–9.3) respectively. Ever cigarette smoking was associated with lung carcinoid (OR=1.3; 95%CI, 1.01–1.9) especially among heavy smokers (20 cigarettes per day), (OR=1.7; 95%CI, 1.01–2.9). Ever or heavy alcohol consumption (= 60 ml ethanol/day) was not significantly related to LGNET of any site. The significantly elevated risk for carcinoid tumors extended to participants with a family history of breast, colon, esophageal, pancreas, prostate, and renal cancers after adjustment for demographic and environmental risk factors (P&lt;.05). Conclusion: Smoking, DM, and family history may increase the risk of LGNET of various sites. Determining environmental and genetic factors related to LGNET may lead to development of surveillance and prevention strategies for high-risk individuals. No significant financial relationships to disclose.
Abstract P5-05-02: Regulation of glucose metabolism by the RUNX2 transcription factor has a negative impact on mitochondrial function in breast cancer cells
Authors: MS Kim, M Choe, H Cho, BM Polster, GD Girnun, A Passaniti
Journal: Cancer Research (2016)

Abstract The RUNX2 transcription factor regulates breast cancer (BC) metastasis to bone and is itself a target of IGF-1 signaling pathways. We have shown that glucose can activate RUNX2 phopshorylation through IGF-1 receptor signaling and that RUNX2 was associated with inhibition of pyruvate dehydrogenase (PDHA1) activity and repression of mitochondrial respiration in BC cells. However, the mechanisms by which RUNX2 alters mitochondrial function and supports an oncogenic phenotype are not completely known. RUNX2 expression in a luminal BC cell line increased expression of glycolytic genes, and sensitivity to glucose starvation. However, RUNX2 knockdown in a triple-negative BC cell line inhibited expression of glycolytic genes. RUNX2 also repressed mitochondrial oxygen consumption rates (OCR), a measure of oxidative phosphorylation while overexpression of SIRT6, a NAD-dependent histone deacetylase, increased respiration in RUNX2-positive cells. RUNX2 repressed SIRT6 expression directly at the transcriptional and post-translational levels. High SIRT6 expression was observed in normal mammary tissue and cells that did not express RUNX2 but endogenous SIRT6 expression was low in malignant BC tissues or cell lines, which expressed high levels of RUNX2. These results suggest that SIRT6, a known tumor suppressor, was a critical mediator of these RUNX2-regulated metabolic changes. These results support a hypothesis whereby RUNX2 upregulation during BC progression leads to inactivation of the SIRT6 tumor suppressor to promote tumorigenesis. It will be important to investigate further changes in mitochondrial function to understand the precise mechanisms by which RUNX2 regulates BC metabolism. Citation Format: Kim MS, Choe M, Cho H, Polster BM, Girnun GD, Passaniti A. Regulation of glucose metabolism by the RUNX2 transcription factor has a negative impact on mitochondrial function in breast cancer cells. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-05-02.
Should we bother subclassifying Hodgkin's disease?
Authors: P J Rosen
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.3.275 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3950672 Should we bother subclassifying Hodgkin's disease? P J RosenxP J RosenSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.3.275 First Page PDF © 1986 by American Society of Clinical Oncology
Noninvasive Detection of Metastases and Follicle Density in Ovarian Tissue Using Full-Field Optical Coherence Tomography
Authors: Inge T.A. Peters, Paulien L. Stegehuis, Ronald Peek, Florine L. Boer, Erik W. van Zwet, Jeroen Eggermont, Johan R. Westphal, Peter J.K. Kuppen, J. Baptist Trimbos, Carina G.J.M. Hilders, Boudewijn P.F. Lelieveldt, Cornelis J.H. van de Velde, Tjalling Bosse, Jouke Dijkstra, Alexander L. Vahrmeijer
Journal: Clinical Cancer Research (2016)

Autotransplantation of ovarian tissue can be used to restore fertility in patients with cancer following gonadotoxic treatment. Whether this procedure is safe remains unclear, as current tumor detection methods render the ovarian tissue unsuitable for transplantation. Full-field optical coherence tomography (FF-OCT) is an imaging modality that rapidly produces high-resolution histology-like images without the need to fix, freeze, or stain the tissue. In this proof-of-concept study, we investigated whether FF-OCT can be used to detect metastases in ovarian tissue, thereby increasing the safety of ovarian tissue autotransplantation. We also evaluated whether cortical ovarian tissue and follicles remain viable following FF-OCT imaging.Formalin-fixed, paraffin-embedded tissue samples were obtained from seven normal ovaries and fourteen ovaries containing metastases and/or micrometastases. These samples were deparaffinized and imaged using FF-OCT. The FF-OCT images were then compared with corresponding hematoxylin and eosin-stained tissue sections. Finally, we examined the effect of FF-OCT imaging on the viability of ovarian tissues and follicles in fresh bovine ovarian tissue using a glucose uptake and neutral red staining, respectively.FF-OCT illustrated both normal structures and metastases in ovarian tissue within minutes. Primordial follicles were readily identifiable. Finally, tissues and follicles remained viable following FF-OCT imaging for up to 180 and 60 minutes, respectively.FF-OCT imaging is a promising method for the noninvasive detection of metastases, including micrometastases, in ovarian tissue. Moreover, this method facilitates the selection of cortical ovarian tissue with the highest density of primordial follicles, potentially increasing the likelihood of restoring ovarian function following ovarian tissue autotransplantation. Clin Cancer Res; 22(22); 5506-13. ©2016 AACR.
Divorce and assortative mating among depressed patients
Authors: K R Merikangas
Journal: American Journal of Psychiatry (1984)

Fifty-six married depressed patients were studied together with their spouses an average of 2 years after their discharge from the hospital. Thirty of the patients had psychiatrically ill spouses and 26 had psychiatrically well spouses. On follow-up the group as a whole had a divorce rate nine times the expected rate for the population. Couples in which both members were ill had a significantly higher divorce rate than couples in which only one member was affected. The authors suggest that the psychiatric status of the spouse of a depressed patient may be a significant factor in marital maladjustment and divorce.
Building and Validating Complex Models of Breast Cancer Risk
Authors: William D. Dupont, Jeffrey D. Blume, Jeffrey R. Smith
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Cardiac Safety Assessment of Adjuvant Nonpegylated Liposomal Doxorubicin (Npld) Plus Cyclophosphamide (C) Followed By Paclitaxel (P) in Elderly Breast Cancer (Ebc) Women
Authors: L. Coltelli, L. Marcucci, A. Fontana, S. Lucchesi, G. Arrighi, B. Salvadori, M. Filidei, A. Falcone, G. Allegrini
Journal: Annals of Oncology (2014)
Letter to the editor. Spotlight on measles 2010: Timely administration of the first dose of measles vaccine in the context of an ongoing measles outbreak in France
Authors: A Gagneur, D Pinquier
Journal: Eurosurveillance (2010)

Preview this article: Letter to the editor. Spotlight on measles 2010: Timely administration of the first dose of measles vaccine in the context of an ongoing measles outbreak in France, Page 1 of 1 < Previous page | Next page > /docserver/preview/fulltext/eurosurveillance/15/41/art19689-en-1.gif
WITHDRAWN: A comparative study of thermo-sensitive hydrogel with water-insoluble paclitaxel in molecule, nanocrystal and microcrystal dispersion
Authors: Zhiqiang Lin, Dong Mei, Xianhui Chen, Zhaoyang Wang, Bing He, Hua Zhang, Xueqing Wang, Wenbing Dai, Qiang Zhang
Journal: Asian Journal of Pharmaceutical Sciences (2015)

This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
Transurethral Prostatectomy
Authors: S L Yong
Journal: BMJ (1944)

This attractive monograph on an important urologic surgical procedure represents an authoritative compilation of all worth-while essentials for good transurethral surgery on the obstructing prostate gland. The author makes no claims for originality but carefully explains that the technics and procedures are those employed in his first class university urologic department. As narrated by Dr. Nesbit, the technics may well be used by all urologists and the setup might be adopted by any well regulated urologic department. The initial chapter on arterial distribution within the prostate gland, by Rubin H. Flocks, is complete in anatomic detail and serves as a background for the author's transurethral surgical approach. The original illustrations of William P. Didusch are beautiful and so completely descriptive that any urologist could follow Dr. Nesbit's surgical technics with absolute accuracy. An important detail of surgical procedure is Dr. Nesbit's determination of blood loss at the time of operation.
Catatonialike symptomatology and withdrawal dyskinesias
Authors: M I Good
Journal: American Journal of Psychiatry (1976)

The authors describes a patient who presented catatonialike symptoms and dyskinesias associated with glutethimide discontinuance and antihistamine use. He hypothesizes that altered dopamine metabolism may produce some of the unusual neuropsychiatric characteristics of glutethimide withdrawal. Drug-withdrawal catatonia may be an additional entity in the differential diagnosis of catatonialike states of organic etiology.
381P Efficacy of ginger (G) in control of chemotherapy induced nausea and vomiting (CINV) in breast cancer patients (BCPs) receiving doxorubicin-based chemotherapy (DBCT)
Authors: M. Ansari, M. Mohammadianpanah, S. Omidvari, A. Mosalaei, N. Ahmadloo, H. Nasrollahi, S.H. Hamedi, P. Porouhan
Journal: Annals of Oncology (2015)
Lymphoscintigraphy for the Assessment of Autologous Stem Cell Implantation in Chronic Lymphedema
Authors: Yamilé Peña Quián, Porfirio Hernández Ramirez, Juan F. Batista Cuellar, Alejandro Perera Pintado, Marco A. Coca Pérez
Journal: Clinical Nuclear Medicine (2014)

Lymphoscintigraphy is the criterion standard technique for the diagnosis of lymphedema. The authors present the images acquired before and 6 months after implantation of autologous stem cells in 2 patients with chronic lymphedema of the lower limbs. The stem cells implantations were carried out by multiple superficial and deep injections in the trajectory of the lymphatic vessels and also in the inguinal region. A volume of 0.75 to 1.00 mL of cell suspension (1.0–2.2 × 109 stem cells) was administered in each injection site. The anatomy and function of the lymphatic system were evaluated.