tbuckley/cabot-search huggingface dataset:
Corneal Disease
Authors: Richard A. Thoft
Journal: New England Journal of Medicine (1978)

FORMING the central, anterior portion of the ocular globe, the transparent cornea not only makes up part of the tough outer coat of the eye but also plays a primary part in determining its optical characteristics. A thin layer of epithelial cells forms its surface, with a 0.5-mm layer of collagen fibers making up the stroma. A single layer of endothelial cells covers the back surface, and serves to keep the cornea in a deturgesced state by actively transporting ions and water into the anterior chamber.Most corneal disease and trauma produce varying proportions of vascularization, surface irregularity and scar . . .
AB0654 Efficacy and Safety of Rituximab in Patients with Anca Associated Vasculitis in Real Life
Authors: K. Thomas, C. Koutsianas, A. Makris, P. Giannou, D. Petras, D. Vassilopoulos
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rituximab (RTX) is a novel, recently approved therapeutic agent for the treatment of active ANCA-associated vasculitis (AAV, Granulomatosis with polyangiitis-GPA, Microscopic polyangiitis-MPA) with limited data available from daily clinical practice. <h3>Objectives</h3> To study the efficacy and safety of RTX in patients with AAV in real life settings. <h3>Methods</h3> Retrospective study of all patients with active AAV treated with RTX in our tertiary center between 2010 and 2015. <h3>Results</h3> 16 patients with active AAV were included (GPA n=12, MPA n=4); 50% females with a mean age of 61.8±13.9 years and median disease duration of 33.5 months. The majority of patients had generalized disease (88%) and the most commonly involved organs were lungs (75%), kidney (63%), joints (50%) and ENT (31%). The patients were followed for a mean period of 21.5±16.1 months. Eleven (68%) patients were treated with RTX due to resistant or relapsing disease and 5 (32%) received RTX as initial treatment. Seven patients received 1 cycle, one patient 2 cycles and 8 patients received ≥3 cycles of RTX (1 gm x 2, 15 days apart). Among patients who received ≥1 cycle of RTX (n=9), 6 received RTX on a regular basis (every 6 months) and 3 at relapse. During treatment, a statistically significant improvement in disease activity was observed (BVAS/WG before RTX was 4.8 and decreased to 0.9 and 0.8 at 6 and 12 months, p=0.001 and 0.003 respectively). At 6 months, 87% of patients (13/15) responded to therapy (6 showed complete and 7 partial response). Additionally, one patient who had not responded at 6 months demonstrated complete response at 9 months. Among the 13 responders, 6 (46%) relapsed during follow up. The majority of relapses were minor (5/6, 83%) and occurred mainly in patients not receiving RTX in a regular basis (4/6, 67%). One patient with GPA and fulminant pulmonary-renal syndrome died from septic shock one month after RTX administration (6%). No other serious infections or allergic reactions were noticed during the follow up period. <h3>Conclusions</h3> These real life data confirm the excellent efficacy and safety of RTX in patients with active newly diagnosed or relapsing AAV. <h3>Acknowledgements</h3> This work was supported in part by research grants from the Special Account for Research Grants (S.A.R.G.), National and Kapodistrian University of Athens, Athens, Greece. <h3>Disclosure of Interest</h3> None declared
FRI0568 Toward Standardized Musculoskeletal Ultrasound (MSUS) in Paediatric Rheumatology: Age Related Msus Normal Findings
Authors: P. Collado, J. Vojinovic, J.C. Nieto, D. Windschall, S. Magni Manzoni, G.A.W. Bruyn, A. Iagnocco, M.A. D'Agostino, E. Naredo
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> The OMERACT Ultrasound Task Force recently produced MSUS standard definitions of normal joint findings in healthy children. (1) Since joints anatomy changes during childhood, the group decided to collect normal joint images according to different age groups, in order to produce a reference atlas for future MSUS studies in paediatric arthritis. <h3>Methods</h3> Prospective multicentre study: four experts in paediatric MSUS independently collected representative images of four joints (knee, ankle, wrist and second metacarpophalangeal) in 4 different predefined age groups. Experts used their own B-mode and Doppler settings for getting the best quality image and the highest sensitivity for low blood flow, and predefined scanning procedures. All images were evaluated for quality parameters as follow: image clearly fulfil the validated B-mode and Doppler US definitions and display the agreed scanning landmarks. In order to insure the reliability across machines an expert performed the same examinations using 2 different US machines. <h3>Results</h3> Sixty-four healthy children were scanned. The quality of images was consistent across examiners. According to the age MSUS showed clearly age-related variations of joint morphology and vascularization, the latter more frequently detected within the epiphyseal cartilage at earlier age (Figure 1). Depending on the degree of ossification of the epiphyseal cartilage, it is showed as anechoic/hypoechoic structure which thickness was decreasing as the child was getting older. Whereas the US appearance of tendons and ligaments was the same in all age groups. There was high to good level of consistency of images quality between the two different US machines (GE Logic E9 vs GE Logic e). <h3>Conclusions</h3> We provided a reference atlas of normal images according to the age, and created baseline knowledge of normal morphology, including blood vessels in the four joints examined. This atlas will help to differentiate normal from abnormal findings in paediatric MSUS. <h3>References</h3> Roth J, Jousse-Joulin S, Magni-Manzoni S, Rodriguez A, Tzaribachev N, Iagnocco A, Naredo E, D9Agostino MA, Collado P and the OMERACT Ultrasound Group. Definitions for the sonographic features of joints in healthy children. Arthritis Care Res 2014; DOI: 10.1002/acr.22410 <h3>Disclosure of Interest</h3> None declared
UEFA making vital contribution to football medicine
Authors: Marc Vouillamoz
Journal: British Journal of Sports Medicine (2016)

UEFA contributes vigorously to football medicine, prevention of injuries and sports science. All of UEFA's medical projects are managed by UEFA's medical unit under the direction of the UEFA Medical Committee—13 highly respected specialist football doctors from around Europe. Here I outline five projects whereby UEFA advances the medical aspect of football and summarise UEFA's position on the role of football doctors.

The UEFA Elite Club Injury Study project was initiated in 2001 and has been led by Professor Jan Ekstrand, and by the Football Research Group, see editorial.1

UEFA's Football Doctor Education Programme (FDEP) transmits vital information and expertise among the European sports medical community. This three-part programme teaches key skills to doctors from all 54 of UEFA's member associations. The programme adopts a blended learning approach, marrying (1) face-to-face workshops where doctors learn and practise techniques with (2) an online e-learning support platform …
Effect of Lack of Glutamine on Subline 2071 Mouse Cells
Authors: Peppers, E. V., Fioramonti, M. C., Westfall, B. B., Evans, V. J., Earle, W. R.
Journal: JNCI Journal of the National Cancer Institute (1958)

Journal Article Effect of Lack of Glutamine on Subline 2071 Mouse Cells Get access E. V. Peppers, E. V. Peppers Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar M. C. Fioramonti, M. C. Fioramonti Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar B. B. Westfall, B. B. Westfall Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar V. J. Evans, V. J. Evans Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar W. R. Earle W. R. Earle Laboratory of Biology, National Cancer Institute,2Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 21, Issue 3, September 1958, Pages 611–620, https://doi.org/10.1093/jnci/21.3.611 Published: 01 September 1958 Article history Received: 25 April 1958 Published: 01 September 1958
Medicine court, II: Rivers in practice
Authors: F H DeLand, N M Borenstein
Journal: American Journal of Psychiatry (1990)

The authors conducted a retrospective study of the initial impact (1986-1987) of the Rivers v. Katz decision involving patients' right to refuse treatment at New York State's largest forensic psychiatric hospital. Of 18 petitions submitted, 15 cases were adjudicated. All 15 patients were found incompetent, and all treatment plans submitted were approved by the court. Most patients selected for Rivers hearings were diagnosed as having chronic schizophrenia and/or were older than the hospital population. A comparison of the implementation of the Rivers decision with that of Rogers v. Commissioner of Mental Health in Massachusetts showed Rogers to be significantly more expensive in human resources, time, and money.
Clinical and immunological studies of 49 cases of various types of intercellular IgA dermatosis and 13 cases of classical subcorneal pustular dermatosis examined at Kurume University
Authors: T. Hashimoto, K. Teye, N. Ishii
Journal: British Journal of Dermatology (2016)

Intercellular IgA dermatosis (IAD) is a subset of autoimmune bullous disease exclusively with IgA antikeratinocyte cell-surface antibodies. The classification and pathogenesis of this condition are still obscure.To classify IAD and study its pathogenesis.From our cohort of 5402 cases of autoimmune bullous disease, we selected 49 cases of various types of intercellular IgA dermatosis (IAD) and 13 cases of classical subcorneal pustular dermatosis (SPD), for which sera and information were available. We studied these cases clinically and immunologically.There were 17 SPD-type IAD, 12 intraepidermal neutrophilic IgA dermatosis (IEN)-type IAD, two IgA-pemphigus vegetans, four IgA-pemphigus foliaceus, six IgA-pemphigus vulgaris and eight unclassified IAD cases. There was no sex predominance, and the average age at disease onset was 45·9 years. Clinically, bullous and pustular skin lesions developed on various sites, particularly intertriginous areas. Histopathology showed intraepidermal blisters or pustules at the upper epidermis in the SPD-type and at the midepidermis in the IEN-type. Immunological studies revealed that direct immunofluorescence, indirect immunofluorescence of normal human skin and enzyme-linked immunosorbent assays (ELISAs) of recombinant proteins of desmogleins and desmocollins frequently showed positive results, although no antigens were detected in many cases. All cases of classical SPD, which showed no positive immunological results, were indistinguishable clinically and histopathologically from SPD-type IAD.The present study of the largest cohort of cases of IAD showed that the major subtypes are SPD and IEN, and that the combination of indirect immunofluorescence and ELISAs of desmogleins and desmocollins, in addition to direct immunofluorescence, was useful for the diagnosis of IAD and its subtypes.
THU0280 Long Term Follow-Up Results of Endovascular Repair in the Management of Arterial Stenosis Caused by Takayasu Arteritis
Authors: A. Gulcu, S. Gezer, P. Cetin, S. Akar, N. Akkoc, F. Onen, A.Y. Goktay
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Takayasu9s Arteritis (TA) is a chronic arteritis of the aorta and its major branches. Patients may require endovascular repair in long term follow-up. <h3>Objectives</h3> The aim of this retrospective study was to report our long term follow-up results of endovascular repair in the management of arterial stenosis caused by TA. <h3>Methods</h3> We retrospectively analyzed the outcome of endovascular interventions including angioplasty and angioplasty with stenting in patients with arterial stenosis caused by TA. The patients were followed-up in the Rheumatology out-patient clinic at 3 monthly intervals. Each visit included the evaluation of clinical symptoms, acute-phase reactants and regulation of the medical treatment including glucocorticoids and immunosuppressive drugs. For the evaluation of outcome of the interventional procedure, patients underwent Doppler ultrasonography and MR angiography routinely at every 6 months. Catheter angiography was performed if there was any suspicion of restenosis or occlusion <h3>Results</h3> This study included 35 patients with TA (31 female, mean age: 42.5 years) who fulfilled the American College of Rheumatology 1990 Criteria for the diagnosis of TA. All patients had symptomatic arterial stenosis proven by catheter angiography. A total of 67 endovascular procedures were performed for 49 arterial stenotic lesions of the patients. Clinical inactivity of the disease was provided with immunosuppressive treatment before any interventions. Treatment of recurrent stenosis by a second endovascular procedure was performed in 11 (22.5%) lesions. The mean follow-up interval after endovascular procedure was 81 months (range 12-144 months). Twenty two (33%) of total 67 endovascular interventions resulted in restenosis or occlusion. Among all 49 arterial lesion, only four (8%) lesions (one common iliac, one renal, one celiac and one thoracic aortic) were occluded at the time of the final evaluation. Kaplan-Meier survival analyses of the renal arterial lesions showed that the overall 1- and 8-year restenosis-free survival rates of renal arterial interventions were 74% and 57%, respectively. <h3>Conclusions</h3> This study suggests that long term patency of TA lesions is related with control of the disease activity by optimal immunosuppressive therapy before and after the initial endovascular procedure. Performing reinterventions with close monitoring of the arterial lesion should not be avoided for better outcomes. <h3>Disclosure of Interest</h3> None declared
The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children
Authors: T Lion, OA Haas, J Harbott, E Bannier, J Ritterbach, M Jankovic, FM Fink, A Stojimirovic, J Herrmann, HJ Riehm
Journal: Blood (1992)
Early-onset pediatric atopic dermatitis is TH2 but also TH17 polarized in skin
Authors: Hitokazu Esaki, Patrick M. Brunner, Yael Renert-Yuval, Tali Czarnowicki, Thy Huynh, Gary Tran, Sarah Lyon, Giselle Rodriguez, Supriya Immaneni, Donald B. Johnson, Bruce Bauer, Judilyn Fuentes-Duculan, Xiuzhong Zheng, Xiangyu Peng, Yeriel D. Estrada, Hui Xu, Christina de Guzman Strong, Mayte Suárez-Fariñas, James G. Krueger, Amy S. Paller, Emma Guttman-Yassky
Journal: Journal of Allergy and Clinical Immunology (2016)
Endoscopic reintervention for stent dislodgement after endoscopic ultrasound-guided choledochoduodenostomy
Authors: Sho Kitagawa, Kana Hatayama, Hiroyuki Miyakawa
Journal: Endoscopy (2015)

Endoscopic ultrasound-guided choledochoduodenostomy (EUS-CDS) has been performed as an alternative drainage technique when endoscopic retrograde cholangiopancreatography (ERCP) fails [1] [2]. This report describes a case of complete dislodgement of a self-expanding metal stent (SEMS) after EUS-CDS that was successfully treated by endoscopic reintervention.
United European Gastroenterology Week 2003: Perspectives in Gastrointestinal Endoscopy
Authors: T Rösch
Journal: Endoscopy (2004)

The endoscopic abstracts from the 2003 United European Gastroenterology Week (UEGW) in Madrid provided a good overview of current topics being investigated - mostly in Europe, but also in the Far East and the Americas. This review covers all of the abstracts from oral presentations and a selection of abstracts from a few posters for relevant, large-scale, and/or randomized studies. Only brief references to key papers in endoscopy published recently will be made, since these are mostly covered in the state-of-the-art reviews in this journal.
AB1081 Glycosaminoglycan Chemical Exchange Saturation Transfer (Gagcest) of Lumbar Intervertebral Discs in Patients with Axial Spondyloarthritis: Leads Inflammation to Local Gag-Lost?
Authors: P. Sewerin, C. Schleich, A. Müller-Lutz, R. Sengewein, G. Antoch, R. Brinks, F. Miese, M. Schneider, B. Ostendorf
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Objectives</h3> To assess glycosaminoglycan (GAG) content of lumbar intervertebral discs (IVD) in patients with spondyloarthritis (SpA) using glycosaminoglycan chemical exchange saturation transfer (gagCEST) in high-field magnetic resonance imaging (MRI). <h3>Methods</h3> Ninety lumbar intervertebral discs of nine patients with predominantly axial SpA (eight patients with ankylosing spondylitis; one patient with spondylitis related to inflammatory bowel disease; mean age: 44.1±14.0 years; range: 27 - 72 years) and 18 age-matched healthy controls were examined at a 3T MRI scanner in this prospective study. The MRI protocol included standard morphological, sagittal T2 weighted (T2w) images to assess Pfirrmann MRI-score of the five lumbar inter vertebral discs (IVD, L1 to S1) and biochemical imaging with gagCEST to calculate the local GAG content of nucleus pulposus (NP) and annulus fibrosus (AF). Prior to statistical testing of gagCEST effects in patients and controls, IVDs were classified according to the Pfirrmann score. <h3>Results</h3> Pooled non-degenerative IVDs (Pfirrmann 1 and 2) had significantly lower gagCEST effects in patients suffering from SpA compared to healthy controls in NP (1.76±1.47; p&lt;0.001) and AF (1.31±1.16; p&lt;0.001) by comparing the differences of the means. No significant difference of GAG values was found in degenerative IVDs between patients and controls in NP and AF. <h3>Conclusions</h3> GagCEST analysis of morphologically non-degenerative IVDs demonstrated significantly lower GAG values in patients with axial SpA possibly representing a depletion of GAG in SpA in the absence of morphologic degeneration. GagCEST may be a powerful research tool to access IVD composition in early SpA and to investigate therapy effects on GAG content in advanced studies. <h3>Disclosure of Interest</h3> None declared
SAT0228 High Doses of Alfacalcidol or Prednisone Combined with Basic Therapy – are There Some More Advantages for Patients with Active Rheumatoid Arthritis?
Authors: K. Simic Pasalic, T. Zivanovic Radnic, M. Sefik Bukilica, A. Andjelkovic, N. Damjanov, J. Vojinovic
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The discovery of vitamin D receptor (VDR) in immune cells and the fact that some of these cells produce D hormone, indicated its antiinflammatory and immunoregulatory properties. Alfacalcidol is a VDR agonist. <h3>Objectives</h3> To investigate the clinical effect of adding high doses of alfacalcidol or prednisone in patients with active rheumatoid arthritis (RA), to standard basic therapy <h3>Methods</h3> The study which was approved by the Ethics Committee and the Drugs Agency and included active RA patients from the Rheumatology Institute in Belgrade, on standard prior methotrexate (MTX) use, for more than 3 months. After signing a consent for participation, demographic and clinical data were collected, disease activity (DAS 28), functional status (HAQ questionnaire), muscle function (timed up and go test -TUG and six minutes walk test- 6MWT) and quality of life (SF36 questionnaire) were assessed. Patients were randomly assigned to receive three-months treatment of 1 μg, 2μg, 3μg alfacalcidol or prednisone 20mg orally daily, with background MTX. They were monthly followed for clinical and laboratory findings, as well as adverse events (AE). At the end of treatment period, all tests were repeated and compared with the baseline ones. Statistical analysis was performed using the SPSS package. <h3>Results</h3> Out of 67 pts, who were comparable, 39 were females, average age 56,36 years, disease duration 7,65 years, DAS28 5,6, HAQ 0,58, MTX dose 15,48mg/weekly, serum 25(OH)D3 level 31.5 ng/ml. After 12 weeks of treatment, all four treatment arms significantly reduced DAS 28 (5,6 vs 4,4), HAQ (0,58 vs 0,4), improved PSC QoL (36,39 vs 38,9), 6MWT (404,5 vs 464 m) (<i>p</i>=0,01, 0,03 and 0,001 respectively), while patients receiving alfacalcidol (N=51) also improved TUG (7,26 vs 6,69s), MCS QoL (48,1 vs 50,57), serum levels of HDL cholesterol (1,5 vs 1,62 mmol/l, <i>p</i>=0,006). Serum levels of 25(OH)D3 in prednisone users (N=16) significantly decreased (37,02 vs 21,93 ng/ml, <i>p</i>=0,000). Multiple comparison showed that alfacalcidol 2mg treated pts (N=19) improved DAS28, HAQ, PCS and MCS QoL significantly better than others (<i>p</i>&lt;0.05). Urinary calcium significantly increased in alfacalcidol treated ones, yet not exceeding URL (0,156 vs 0,28 g/dU, <i>p</i>=0,001). <h3>Conclusions</h3> Three months treatment with high doses of alfacalcidol in vitamin D replete active RA patients, led to improvement of disease activity, functional status, PCSQoL comparable to prednisone use, but also improved MCSQoL, muscle function and serum levels of HDL cholesterol, while preserving serum levels of 25(OH)D3. <h3>Disclosure of Interest</h3> None declared
Cidofovir Treatmenf For Hemorrhagic Cystitis After Allogeneic Hematopoietic Stem Cell Transplantation For High Risk Hematological Malignancies
Authors: Lara Crucitti, Matteo Carrabba, Sarah Marktel, Andrea Assanelli, Andrea Salonia, Raffaella Greco, Luca Vago, Francesca Lorentino, Maria Teresa Lupo Stanghellini, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Fabio Ciceri
Journal: Blood (2013)
The Deoxyribonucleic Acid (DNA) Content of Sternberg-Reed Cells of Hodgkin's Disease&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: N. L. Petrakis, W. L. Bostick, B. V. Siegel
Journal: JNCI Journal of the National Cancer Institute (1959)

The DNA content of Sternberg-Reed cells of Hodgkin's disease was determined by Feulgen cytophotometry. An increased DNA content per cell nucleus above the diploid (2n) level was found which corresponded to the nuclear size and degree of nuclear lobulation. The findings were considered as evidence in support of the concept that the Sternberg-Reed nuclei undergo endomitosis and polyploidization during their development from the reticulum cells.
Simple but reliable endoscopic sliding closure with ring-shaped surgical thread after endoscopic submucosal dissection
Authors: Hirohito Mori, Hideki Kobara, Noriko Nishiyama, Shintaro Fujihara, Nobuya Kobayashi, Tsutomu Masaki
Journal: Endoscopy (2015)

Although several reports have suggested that the inflammation after endoscopic submucosal dissection (ESD) of the colon can be reduced by closure of the ulcer [1] [2], a simpler and more reliable closure has not been reported for ulcers over 6 cm in diameter.