tbuckley/cabot-search huggingface dataset:
Prolonged Survival Of Poor Risk Follicular Lymphoma Patients Following Primary Treatment With Rituximab-Supplemented CHOP Or HDS With Autograft: Long-Term Results Of The Multicenter Randomized GITMO/FIL Trial
Authors: Corrado Tarella, Fabio Benedetti, Carola Boccomini, Caterina Patti, Anna Maria Barbui, Alessandro Pulsoni, Maurizio Musso, Anna Marina Liberati, Guido Gini, Claudia Castellino, Fausto Rossini, Fabio Ciceri, Delia Rota Scalabrini, Caterina Stelitano, Francesco Di Raimondo, Tommasina Perrone, Alessandra Tucci, Atto Billio, Francesco Zallio, Valerio Zoli, Angela Congiu, Franco Narni, Alessandra Dondi, Guido Parvis, Gianpietro Semenzato, Paolo Corradini, Riccardo Bruna, Angela Gueli, Barbara Mantoan, Roberto Passera, Michele Magni, Marco Ladetto
Journal: Blood (2013)
Abstract 3814: Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer
Authors: Jian Yang, Juncheng Wei, Yushi Wu, Zhilin Wang, Yuqi Guo, Xin Li
Journal: Cancer Research (2015)

Abstract Previous studies showed that metformin is associated with lower risk of tumorigenesis for several cancer types including prostate cancer. However, the molecular basis of anti-tumor effect induced by this biguanide agent is still unclear. In this study, we identified miR-708-5p as a novel downstream effector of metformin in prostate cancer. By increasing the expression of miR-708-5p, metformin suppresses the expression of endoplasmic reticulum (ER) membrane protein neuronatin (NNAT) and subsequently induces apoptosis of prostate cancer cells through ER stress pathway. Notably, down-regulated NNAT is associated with down-regulated intracellular calcium level and induces malformation of endoplasmic reticulum-ribosome structure which is revealed by electronic microscopy. Furthermore, western blot shows that the unfolded-protein response (UPR) proteins including CHOP, p-eIF2α, Calreticulin, GRP78 and ATP2A1, all of which are also considered as the ER stress markers, were up-regulated by metformin and miR-708-5p. Importantly, an increased apoptosis of prostate cancer cells is also observed when miR-708-5p mimic or NNAT siRNA was introduced. In summary, our findings clearly reveals that metformin stimulates miR-708-5p to target on NNAT mediated response to ER stress and apoptosis. This novel regulatory mechanism of metformin in prostate cancer cells not only advances our knowledge on the molecular mechanism of metformin in cancer progression, but also provide a promising therapeutic target for prostate cancer treatment. Citation Format: Jian Yang, Juncheng Wei, Yushi Wu, Zhilin Wang, Yuqi Guo, Xin Li. Metformin induces ER stress-dependent apoptosis through miR-708-5p/NNAT pathway in prostate cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3814. doi:10.1158/1538-7445.AM2015-3814
Long-Term Effects of a Long-Acting β<sub>2</sub>-Adrenoceptor Agonist, Salmeterol, on Airway Hyperresponsiveness in Patients with Mild Asthma
Authors: David Cheung, Mieke C. Timmers, Aeilko H. Zwinderman, Elisabeth H. Bel, Joop H. Dijkman, Peter J. Sterk
Journal: New England Journal of Medicine (1992)

Asthma is characterized by hyperresponsiveness of the airways to bronchoconstrictive stimuli. Long-acting β2-adrenoceptor agonists have been introduced as a new therapeutic approach, but there is growing concern about whether control of asthma may deteriorate with the regular use of these agents. We investigated the long-term effects of the β2-agonist salmeterol on bronchodilation and on airway hyperresponsiveness to the bronchoconstrictive agent methacholine in mild asthma.
Case 7-2012
Authors: William S. David, David A. Chad, Avinash Kambadakone, E. Tessa Hedley-Whyte
Journal: New England Journal of Medicine (2012)

A 79-year-old man was admitted to the hospital because of pain and weakness in the legs. He had multiple chronic medical problems and took numerous medications, with no recent changes. Examination revealed leg weakness and decreased reflexes.
Large Conserved Domains Of Low DNA Methylation Maintained By 5-Hydroxymethycytosine and Dnmt3a
Authors: Mira Jeong, Deqiang Sun, Min Luo, Yun Huang, Myunggon Ko, Lucas Chavez, Grant A Challen, Benjamin Rodriguez, Xiaotian Zhang, Liubin Yang, Hui Wang, Rui Chen, Rebecca Hannah, Sang-Bae Kim, Ju-Seog Lee, Berthold Gottgens, Preethi Gunaratne, Lucy A Godley, Gretchen Darlington, Anjana Rao, Wei Li, Margaret A. Goodell
Journal: Blood (2013)
Occurrence of Convulsive Seizures during Treatment of Asthma with Cortisone Acetate
Authors: Francis C. Lowell, William Franklin, Henry D. Beale, Irving W. Schiller
Journal: New England Journal of Medicine (1951)

CORTISONE is being used in a wide variety of clinical conditions. This drug has profound physiologic effects, and occasional undesirable reactions are to be expected.Several observers have noted convulsive seizures in patients receiving the adrenocorticotrophic hormone (ACTH) of the pituitary body, which is closely related in its effects to Cortisone, but to our knowledge no such case is recorded in the literature. Some of these patients suffered from diseases that are known to cause seizures occasionally. In others the seizures have been ascribed to contamination of the preparation with hormone from the posterior pituitary body or to cerebral edema . . .
Abstract 6031: Impact of Pre-procedural C-reactive Protein on Intravascular Ultrasound Parameters following Everolimus-eluting Stent Implantation: Results from the SPIRIT III Trial
Authors: Daisaku Nakatani, Junya Ako, Masao Yamasaki, Takao Shimohama, Hiromasa Otake, Ichizo Tsujino, Bon-Kwon Koo, Katsuhisa Waseda, Hyeonsoo Chang, Ryota Sakurai, Paul G Yock, Yasuhiro Honda, Wesley Pierson, Krishnankutty Sudhir, Peter J Fitzgerald
Journal: Circulation (2008)

Background: It has been reported that pre-procedual C-reactive protein (CRP) correlates with neointimal hyperplasia following bare-metal stent as well as a certain type of drug-eluting stent implantation. The aim of this study was to investigate potential impact of inflammation, as assessed by high sensitivity-CRP (hs-CRP) collected pre-procedure, on neointimal hyperplasia following everolimus-eluting stent (EES) implantation. Methods: Data were obtained from the SPIRIT III trial, a randomized controlled trial comparing an EES with a paclitaxel-eluting stent. Enrolled patients fulfilled the following criteria patients treated with EES stable angina; and volumetric intravascular ultrasound (IVUS) analysis available at 8 months follow-up. Volume index (volume/length) was calculated for vessel (VVI), plaque (PVI), neointima (NIV), and lumen (LVI). Percent neointimal volume (%NIV) was calculated as (NIV/SVI)× 100. Cross-sectional narrowing (CSN) was defined as neointimal area divided by stent area (%). Results: One-hundred thirty two patients met the inclusion criteria (mean age; 65±9 years, male; 75%). There was no significant correlation between hs-CRP and VVI, PVI, and LVI at either baseline or 8 months follow-up. Furthermore, hs-CRP did not correlate with %NIV (r=−0.071, P=0.416) and max CSN (r=−0.020, P=0.819) at follow-up (figure ). Conclusion: Pre-procedual inflammation assessed by hs-CRP did not affect the neointimal hyperplasia at 8 months following everolimus-eluting stent implantation.
Case 4-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Jerome S. Brody, Eugene J. Mark
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 71-year-old woman was admitted to the hospital because of an abnormal x-ray film of the chest.She was well until 16 months previously, when she complained of vague postprandial epigastric distress. An upper gastrointestinal series showed focal induration in the prepyloric portion of the stomach, with good peristalsis throughout the area; the appearance was attributed to a healed ulcer. A bland diet and an antacid were prescribed, and the symptoms cleared promptly. Thirteen months before entry a repeated upper gastrointestinal series revealed little change. Eight months before admission low-back pain developed, with radiation down the posterior . . .
Acquired Pseudo-Pelger Anomaly of Granulocytic Leukocytes
Authors: Andrew D. Dorr, William C. Moloney
Journal: New England Journal of Medicine (1959)

THE abnormality of granulocytic leukocytes manifested by poor segmentation and condensation of nuclear chromatin was first described by Pelger1 in 1928. Huët2 confirmed these observations and established the genetic characteristics of this disorder in 1931. Since then this benign hereditary trait has been known as the Pelger–Huët anomaly. In 1950 Nachtsheim3 , 4 discovered the heterozygous form in rabbits and, by controlled breeding, produced the homozygous type, which proved lethal. In the same year he demonstrated that the administration of colchicine to rabbits with the heterozygous trait caused the homozygous form of the anomaly.5 Recently, Darte et al.5 and Undritz6 pointed out . . .
The Respiratory Epithelium. II. Hamster Trachea, Bronchus, and Bronchioles&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Peter J. Becci, Ph.D., Elizabeth M. McDowell, B. Vet. Med., Ph.D., Benjamin F. Trump, M.D.
 6
Journal: JNCI Journal of the National Cancer Institute (1978)

The normal female hamster respiratory epithelium at five airway levels was characterized with the use of coordinated morphologic and histochemical techniques. Five morphologic cell types were recognized in the trachea, stem bronchi, and primary bronchl: basal cells and neurosecretory cells that were basally located and did not reach the lumen and mucous cells [mucous goblet cells and small mucous granule cells (SMGC)], indifferent cells showing mucous-ciliary differentiation, and ciliated cells that reached the lumen. Two epithelial cell types were observed in the bronchioles, ciliated cells and nonciliated Clara cells, both of which reached the lumen. Mucous cells presented as either SMGC with a few small periodic acid-Schiff-positive granules (diastase-resistant neutral mucosubstances) or as goblet cells, filled with the same material. Mucous cells were columnar, and the cytoplasm was electron-dense and contained a well-developed endoplasmic reticulum and Golgi complex. The microvilli of the mucous cells were coated more thickly with colloidal iron than either the cilia or microvilli of ciliated cells. Approximately one-half the cells in the trachea, bronchi, and bronchioles were ciliated. Ciliated cells containing intracellular ciliated cysts with normal cilia projecting into a closed space or ciliated cells bearing compound cilia were observed infrequently. Neurosecretory cells were rarely observed. These cells contained characteristic dense-core granules.
Case 18-2005
Authors: Michael G. Muto, Mary Jane O'Neill, Esther Oliva
Journal: New England Journal of Medicine (2005)

A 45-year-old woman noted a mass in her lower abdomen that was intermittently painful. An examination disclosed a slightly tender mass, 4 cm in diameter, on the right side of the lower abdomen. Imaging studies showed a solid mass in the right lower abdominal wall. A diagnostic procedure was performed.
Acquired von Willebrand's Disease
Authors: J. Heinrich Joist, Joseph F. Cowan, Theodore S. Zimmerman
Journal: New England Journal of Medicine (1978)

To define further the factor VIII abnormality in acquired von Willebrand's disease, we performed immunoelectrophoresis of factor VIII antigen, as well as quantitative measurements of the antigen, factor VIII procoagulant activity and von Willebrand factor activity on plasma from an affected 57-year-old man who also had a poorly differentiated lymphocytic lymphoma. No evidence for an inhibitor against factor VIII procoagulant activity or von Willebrand factor activity was detected, but immunoelectrophoresis showed none of the less anodic forms of factor VIII antigen. There were concomitant decreases in total antigen (0.19 U per milliliter) and von Willebrand factor levels (0.12 U per milliliter). Factor VIII-procoagulant activity was borderline low (0.45 U per milliliter). Correction of both the abnormal immunoelectrophoresis pattern and the quantitative abnormalities followed radiotherapy of the lymphoma. The factor VIII abnormalities might have resulted from binding or destruction of the less anodic forms of factor VIII antigen by the malignant lymphocytes. (N Engl J Med 298:988–991, 1978)
The Value of the Methylene Blue Test in the Detection of Bilirubin
Authors: C. Lawrence Holt
Journal: New England Journal of Medicine (1947)

WHEN Fellinger and Menkes1 described a modification of Franke's2 methylene blue test for bile in the urine, they suggested that certain quantitative potentialities of the test existed. They observed that determinations made on twenty-four-hour collections of urine paralleled blood bilirubin levels to a satisfactory degree. Determinations on individual samples, however, were not reliable, since dilution factors, as represented by varying specific gravities of the urine, affected the depth of color that took place after the addition of methylene blue. The depth of color in their technic represented the basis of quantitative interpretation.Gellis and Stokes,3 after considerable investigative studies, reported . . .
Varus and Valgus — No Wonder They Are Confused
Authors: C.Stuart Houston, Leonard E. Swischuk
Journal: New England Journal of Medicine (1980)

In lecturing on pediatric bone disease to medical students, we have become painfully aware that the terms varus and valgus cause great confusion. Every year, when shown a radiograph of coxa valga and asked for the appropriate diagnosis, about a third of the students vote for coxa vara, a third for coxa valga, and a third admit that they do not know.Since radiologists, orthopedic surgeons, and pediatricians use varus and valgus regularly in their conversation and in their reports, we have attributed the ignorance of medical students to their inexperience, coupled with the unfortunate omission of high-school Latin as . . .
ASPIRATION: Phase II study of continued erlotinib beyond RECIST progression in Asian patients (pts) with epidermal growth factor receptor (<i>EGFR</i>) mutation-positive non-small cell lung cancer (NSCLC).
Authors: Keunchil Park, Chun-Ming Tsai, Myung-ju Ahn, Chong-Jen Yu, Sang-We Kim, Virote Sriuranpong, Han Pin Kuo, Jong-Seok Lee, Jin Hyoung Kang, Meng-Chih Lin, Sarayut Lucien Geater, Gee-Chen Chang, Kasan Seetalarom, Ping Fai Peter So, Ruay-Sheng Lai, Ashley Chi Kin Cheng, Eun Kyung Cho, Shang-Hung Chen, Te-Chun Hsia, Tony Mok
Journal: Journal of Clinical Oncology (2012)

TPS7614 Background: First-line erlotinib (an EGFR tyrosine-kinase inhibitor) significantly increased progression-free survival (PFS) vs chemotherapy in phase III trials of pts with EGFR mutation-positive NSCLC. Discontinuation of erlotinib on RECIST disease progression (PD) may lead to rapid disease flare-up; continued erlotinib beyond RECIST PD may extend clinical benefit by slowing progression of this life-threatening disease. We describe ASPIRATION, a large, Asian, multicenter, single-arm, open-label, phase II trial (NCT01310036), which will increase understanding of first-line erlotinib and erlotinib continuation beyond RECIST PD in pts with EGFR-mutated NSCLC. Methods: Pts (n=204) ≥18 yrs with stage IV/recurrent NSCLC, ≥1 measurable lesion (≥10mm), ECOG performance status (PS) 0-2 and positive EGFR mutation status established by local pathology laboratory (that underwent voluntarily QA/QC) are eligible. All pts receive erlotinib 150mg/day. Tumor response is evaluated using RECIST (v1.1). The primary endpoint is PFS. At investigator's discretion, pts may continue on erlotinib beyond RECIST PD, e.g. if they have slow PD (&gt;6 months of partial response/stable disease), asymptomatic minimal PD, or new brain metastasis controlled locally. Pts should not continue erlotinib if they have extracranial PD with symptoms; rapid PD and/or worsening of PS; or life-threatening complications. Pts continuing erlotinib who present with second RECIST PD will discontinue. Secondary endpoints include objective response rate, disease control rate, overall survival, and safety. For the exploratory biomarker study, pre-treatment tumor tissue blocks are collected; remaining tissue (after EGFR mutation testing for eligibility) will be analyzed centrally to study the association of biomarkers and clinical outcomes. Pre-treatment and post-treatment plasma and serum samples will be obtained at various time points for biomarker assays, including EGFR mutations and other candidate NSCLC biomarkers. Recruitment began in Apr 2011; the estimated final data collection for the primary endpoint is Dec 2014.
Case 2-2000
Authors: Daniel S. Pratt, Fiona M. Graeme-Cook
Journal: New England Journal of Medicine (2000)

Presentation of CaseA 74-year-old man was admitted to the hospital because of recent, progressive jaundice.The patient had a long history of hypertension and type 2 diabetes mellitus, both of which were adequately controlled, and of peripheral atherosclerosis. A renal transplantation had been performed 10 years before the current admission because of end-stage diabetic nephropathy, and the patient continued to receive cyclosporine and azathioprine as maintenance therapy. In recent years, he had become confused, with failing memory.The patient resided in a nursing home. Four weeks before admission, progressive jaundice developed, with dark urine and light stools but without . . .
GE-03 * HIGH RATE OF CONCURRENT BRAF-KIAA1549 GENE FUSION AND 1p DELETION IN DISSEMINATED OLIGODENDROGLIAL-LIKE LEPTOMENINGEAL TUMORS
Authors: M. J. Schniederjan, F. J. Rodriguez, T. Nicolaides, T. Tihan, P. C. Burger, A. Perry
Journal: Neuro-Oncology (2015)

INTRODUCTION: Activating fusions of the serine-threonine-kinase-encoding BRAF gene with the nearby gene KIAA1549 have been described in low-grade pediatric brain tumors, including most cerebellar pilocytic astrocytomas and smaller numbers of other, generally low-grade, CNS tumors. Disseminated oligodendroglial-like leptomeningeal tumors (DOLTs) are slowly progressive pediatric tumors with limited, if any parenchymal involvement. In this series, we assessed the status of BRAF-KIAA1549 and chromosomes 1p and 19q, with deletions of the latter known to variably occur in this tumor type. METHODS: 20 archival DOLTs were examined by FISH for BRAF-KIAA1549 fusion, and 17 cases for deletions of 1p and 19q. One case was additionally interrogated by SNP-array. Testing for BRAF-V600E mutation was also performed in nine cases. RESULTS: Of 14 informative cases for BRAF-KIAA1549, 9 were fusion positive by FISH, and one harbored a duplication by SNP-array suggestive of the gene fusion, for a total of 10 of 14 positive cases (71%). FISH revealed loss of 1p in 10/17 cases (59%), with 3 of those also being co-deleted for 19q (18%). Of the 10 cases with BRAF fusions, 8 had 1p deletion (80%) and 1 had 19q co-deletion (10%). None of 9 tested specimens were positive for BRAF-V600E mutation. CONCLUSION: These findings indicate a high rate of concurrent BRAF-KIAA1549 gene fusions and 1p deletions in DOLTs. Although BRAF fusions are typical of pilocytic astrocytomas, 1p deletions are not, confirming that DOLTs are pathologically and genetically distinct. These findings also further separate these oligodendroglial-like tumors from adult oligodendrogliomas, although some overlap remains since 1p19 codeletion is occasionally found in DOLT and rare BRAF fusions have been recently reported in otherwise classic, 1p19q codeleted oligodendroglioma.
Master's Perspective: Joseph Bloomer, M.D.
Authors: Joseph Bloomer
Journal: Hepatology (2016)

1Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of Alabama at BirminghamBirminghamAlabama *ADDRESS CORRESPONDENCE AND REPRINT REQUESTS TO:Joseph Bloomer, M.D.Division of Gastroenterology and HepatologyDepartment of MedicineUniversity of Alabama at BirminghamBirmingham, ALE‐mail: [email protected]Tel: 205‐975‐9698
Pulse corticosteroid therapy with oral dexamethasone for the treatment of adult alopecia totalis and universalis
Authors: Sergio Vañó-Galván, Ángela Hermosa-Gelbard, Natalia Sánchez-Neila, Laura Miguel-Gómez, David Saceda-Corralo, Rita Rodrigues-Barata, Dong-Lai Ma, Pedro Jaén
Journal: Journal of the American Academy of Dermatology (2016)
P0510 : Direct comparisons of fibrotest, APRI, FIB-4, and transient elastography (TE) for the diagnosis of cirrhosis and fibrosis, in patients with chronic hepatitis C (CHC) and B (CHB) using intention to diagnose and bayesian methods. A systematic review
Authors: M. Houot, Y. Ngo, M. Munteanu, S. Marque, T. Poynard
Journal: Journal of Hepatology (2015)
Night Cramps in Young Men
Authors: Joseph H. Nicholson, Abraham Falk
Journal: New England Journal of Medicine (1945)

IT WAS with considerable surprise that we found many young men at an Army Air Force installation who were reporting to the dispensary because of distressing night cramps, since this condition is one usually seen in middle-aged and old people. In the course of nine months, 35 men presented themselves for treatment; in 23 of these cases we are reporting our findings. The remaining 12 patients could not be followed or did not return for a checkup.Night cramps present a fairly typical clinical picture. It is usually that of a person free of symptoms during the day, whether resting . . .
Acute Herpetic Gingivostomatitis in the Adult
Authors: Arthur M. Rogers, Lewis L. Coriell, Harvey Blank, Thomas F. McNair Scott
Journal: New England Journal of Medicine (1949)

THE majority of people, about 70 per cent, experience their first infection with the herpes simplex virus in infancy or early childhood. This infection is usually inapparent, and can therefore only be recognized as having occurred by the presence of circulating antibodies.1 However, in about 1 per cent of all infections, the first attack of the virus can give rise to a serious or even fatal disease. These primary infections, of which the commonest is the clinical entity known as acute herpetic gingivostomatitis,2 3 4 5 6 are well recognized in childhood because they commonly occur in this age group. In adult life, however, . . .
Psychiatric Considerations in the Adjustment of Patients with Poliomyelitis
Authors: H. A. Robinson, J. E. Finesinger, J. S. Bierman
Journal: New England Journal of Medicine (1956)

NO two orthopedic conditions are ever exactly the same to the last detail, nor do any two patients ever show precisely the same array of symptoms. Yet there are essential similarities in symptom patterns that enable the physician to think of one patient as being much like others in his experience and allow him to distinguish meaningfully one group of patients from another. In large measure this patterning is the key to all diagnosis and treatment. In a general way paralytic poliomyelitis resembles a large number of other orthopedic conditions, both as an illness experience for the patient and as . . .