tbuckley/cabot-search huggingface dataset:
P69 Hepatitis delta RNA level and genotype, and hepatitis B surface antigen titre predict response to PEG-interferon in the treatment of chronic hepatitis delta virus
Authors: S Hughes, I Carey, D Shang, M Horner, M Bruce, I Fletcher, T J S Cross, A Suddle, K Agarwal, P M Harrison
Journal: Gut (2010)

Introduction  Hepatitis Delta Virus (HDV) infection is associated with more severe liver disease in individuals with hepatitis B virus (HBV). The only treatment for HDV shown to be of benefit is α-interferon, but predictors of response to therapy are not known.  Aim  To evaluate the efficacy of PEG-interferon α 2a (PEG-IFN) therapy and factors predicting viral response in patients with chronic HBV/HDV co-infection.  Method  Between 2005 and 2010, 14 patients (71% female, median age 32, 57% Black African, 36% Caucasian, 7% Oriental, 79% HBeAg −ve, 100% HDV RNA +ve, 64% HDV genotype 1, 29% HDV genotype 5, 7% HDV genotype 6, 43% cirrhotic) were treated with PEG-IFN 180 mcg/week for a median of 48 weeks. The median follow-up post treatment was 16.5 months. A retrospective analysis was undertaken to assess clinical and virological factors predictive of outcome. HDV RNA was measured by an in-house real-time quantitative PCR assay (range 6.4×102 to 6.4×107 copies/ml), and genotyping was performed by comparison of nucleotide sequences of HDV RNA with previously reported sequences of HDV genotypes 1–8. HBV DNA was measured using the Roche COBAS Ampliprep/TaqMan assay. Hepatitis B surface antigen (HBsAg) titres were measured using the Abbott Architect assay.  Results  In response to PEG-IFN, 64% cleared HDV RNA by end of treatment (EOT), 1 patient with genotype 1 HDV relapsed and 54% remain HDV RNA −ve beyond 24 weeks post-treatment (sustained virological response; SVR); 2 patients subsequently cleared HBsAg. Baseline HDV RNA was significantly higher in non-responders compared to those with SVR (2.1×106 vs 1.3×104 copies/ml, p=0.003) and predicted treatment response (AUROC=1.0, p=0.003). A HDV RNA of >1.96×105 copies/ml predicted treatment failure (p=0.001, positive predictive value 100% and sensitivity 100%). There was a strong correlation between HDV RNA level and HBsAg titre (r=0.82, p 9000 IU/ml predicted treatment failure (p=0.021, positive predictive value 100% and sensitivity of 67%). All patients with HDV genotype non-1 achieved SVR, compared with only 25% of those with HDV genotype 1 (p=0.02). Responders were similar to non-responders with respect to gender, age, liver histology staging and pre-treatment ALT.  Conclusion  PEG-IFN was an effective treatment for chronic HDV, with 54% achieving SVR. Levels of HDV RNA >1.96x105 copies/mL and HBsAg titres >9000 IU/ml predicted treatment failure, whereas HDV genotype non-1 predicted long-term viral clearance.
Physiologische Theorie der Vererbung.
Journal: JAMA (1927)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vitiligo
Authors: Sarah Ringold
Journal: JAMA (2005)

VitiligoV itiligo is a disorder that results in damage to and loss of melanocytes (cells within the skin that produce melanin, the skin' s natural color or pigment).This damage results in patches of depigmented skin.The process primarily affects the skin, but may also affect pigmentation of other sites, including the eyes and hair.Vitiligo may be focal (occurring in only a few patches), segmental (in which the patches occur on one side of the body only), and generalized (patches throughout the body).The course of vitiligo varies and some patients may develop only a few patches while others may experience almost total depigmentation.Vitiligo may affect persons of all ages; however, its onset most commonly occurs during young adulthood.The cause of vitiligo is not completely understood; however, it is thought to be an autoimmune process (a process by which the body produces an immune response against some of its own cells, in this case melanocytes, resulting in their destruction).The February 9, 2005, issue of JAMA includes an article that describes the disorder and discusses available treatments.
Cytogenetic Studies in Multiple Myeloma 2
Authors: George J. Anday, Ben Fishkin, E. Peter Gabor
Journal: JNCI Journal of the National Cancer Institute (1974)

Chromosome abnormalities were found in 70 bone marrow specimens of 38 multiple myeloma (MM) patients. Structural abnormalities were insignificant except for marker chromosomes in 11 patients. Numerical abnormalities ranged from hypodiploidy to hyperdiploidy, and clones were recognized in 7 patients. The diversity of cytogenetic findings without any specificity for MM or its differing product places this hematologic neoplasm into the group of solid malignant tumors without specific chromosome changes. The chromosome changes varied during treatment. Decrease in the proportion of abnormal karyotypes, with increase in normal or hypodiploid and tetraploid metaphases, occurred in remissions. Increase in abnormal metaphases (especially hyperdiploidy with decrease in diploidy) and appearance of marker chromosomes and clones were often associated with relapse. Comparison of initial studies with subsequent chromosome studies was valuable in the assessment of the patients' condition.
F-18 Fluoride Uptake in Calcified Extraosseous Metastases From Ovarian Papillary Serous Adenocarcinoma
Authors: Kanhaiyalal Agrawal, Anish Bhattacharya, Chidambaram Natarajan Balasubramanian Harisankar, Mohammed Labeeb Abrar, Lakhbir Kaur Dhaliwal, Bhagwant Rai Mittal
Journal: Clinical Nuclear Medicine (2012)

Recurrent ovarian papillary serous adenocarcinoma (PSAC) may present with calcified metastatic lesions. Metastases from PSAC are known to show high avidity for Tc-99m methylene diphosphonate, explained by the high content of calcium in the concentrically laminated psammoma bodies. F-18 fluoride PET is a sensitive imaging modality for the detection of osteoblastic bony lesions. The authors present a case of recurrent ovarian PSAC showing uptake of both F-18 fluoride and F-18 fluorodeoxyglycose in multiple soft tissue metastases.
Clone Strains of Pig Kidney Cells With Drug Resistance and Chromosomal Markers&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Morgan Harris, Frank H. Ruddle
Journal: JNCI Journal of the National Cancer Institute (1961)

Two strains of pig kidney cells have been isolated that are resistant to aminopterin and 2,6-diaminopurine, respectively, and that can be identified cytologically by characteristic marker chromosomes. Drug resistance and chromosome patterns in these lines were stable during short-term serial subculture in normal media. Stabilization of marker strains by routine subcloning is recommended, with the use of frozen type specimens for reference or recovery as needed.
Megavitamin Therapy
Authors: Arthur M. Sackler
Journal: JAMA (1975)

<h3>To the Editor.—</h3> I was distressed to note the ad hominem attack on Linus Pauling by Thomas H. Jukes (233:550, 1975) that appeared with an editorial (233:538, 1975). It does not serve the scientific method to practice the discredited procedure of guilt by association, as was done therein by seeking to link Linus Pauling's name with either J. I. Rodale or with the National Health Federation. Despite the fact that I personally do not find the claims made for the megavitamin treatment of the schizophrenias persuasive, I believe that the<i>JAMA</i>article and editorial would have served medicine better if they had been restricted to a presentation or discussion of facts. The article and editorial do not serve the cause of scientific debate when they omit any reference to a significant and growing number of published papers or when they totally omit reference to Pauling's analysis of data in those
EPN-35SERVICE EVALUATION OF EARLY OUTCOMES AND TOXICITY FOR PAEDIATRIC INTRACRANIAL EPENDYMOMAS TREATED WITHIN THE UK PROTON BEAM THERAPY OVERSEAS PROGRAMME
Authors: Jenny Gains, Daniel Indelicato, Andrew Chang, Michael Confer, Nicola Thorp, Yen-Ching Chang, Ed Smith, Allan Hackshaw, Adrian Crellin
Journal: Neuro-Oncology (2016)
Effect of the Number of Prognostically Relevant Mutated Genes on Survival and Leukemia Progression in Primary Myelofibrosis
Authors: Paola Guglielmelli, Terra L. Lasho, Flavia Biamonte, Johannah Score, Carmela Mannarelli, Giada Rotunno, Alessandro Pancrazzi, Animesh Pardanani, Katerina Zoi, Andreas Reiter, Andrew Duncombe, Daniela Pietra, Elisa Rumi, Christy Finke, Naseema Gangat, Rhett P. Ketterling, Ryan A. Knudson, Rebecca R. Laborde, Alberto Bosi, Arturo Pereira, Francisco Cervantes, Giovanni Barosi, Mario Cazzola, Nicholas C.P. Cross, Ayalew Tefferi, Alessandro M. Vannucchi
Journal: Blood (2013)
Research without external funding in North American psychiatry
Authors: E K Silberman, D A Snyderman
Journal: American Journal of Psychiatry (1997)

The authors investigated the extent and characteristics of published psychiatric research from U.S. and Canadian medical schools that was carried out without external funding.They reviewed reports of unfunded research in 14 psychiatric journals, tabulating methodological factors and topics of study. They surveyed first authors about their academic duties and resources used in the studies.Unfunded studies represented 26% of research reports, were usually prospective, most commonly dealt with phenomenology/epidemiology or psychopharmacology, used low levels of technology, and were accomplished on a modest budget of time and money.Unfunded studies make a substantial and economically efficient contribution to psychiatric research. Future investigations should detail the institutional conditions necessary to sustain this type of research productivity.
Adiponectin Enhances Antibacterial Activity of Hematopoietic Cells by Suppressing Bone Marrow Inflammation
Authors: Yosuke Masamoto, Shunya Arai, Tomohiko Sato, Akihide Yoshimi, Naoto Kubota, Iseki Takamoto, Yoichiro Iwakura, Akihiko Yoshimura, Takashi Kadowaki, Mineo Kurokawa
Journal: Immunity (2016)
HG-67PRECLINICAL EFFICACY OF ALK2 INHIBITORS IN ACVR1 MUTANT DIPG
Authors: Diana Carvalho, Kathryn Taylor, Nagore G. Olaciregui, Melanie Valenti, Ruth Ruddle, Alan Henley, Angela Hayes, Alexis De Haven Brandon, Albert Hallsworth, Alan Mackay, Valeria Molinari, Maria Vinci, Sergey Popov, Aicha Boudhar, Paul Brennan, Andrew Moore, Liam Hudson, Swen Hoelder, Alex Bullock, Florence Raynaud, Sue Eccles, Angel M. Carcaboso, Chris Jones
Journal: Neuro-Oncology (2016)
Old dog, new tricks: novel cardiac targets and stress regulation by protein kinase G
Authors: Peter P. Rainer, David A. Kass
Journal: Cardiovascular Research (2016)

The second messenger cyclic guanosine 3′5′ monophosphate (cGMP) and its downstream effector protein kinase G (PKG) have been discovered more than 40 years ago. In vessels, PKG1 induces smooth muscle relaxation in response to nitric oxide signalling and thus lowers systemic and pulmonary blood pressure. In platelets, PKG1 stimulation by cGMP inhibits activation and aggregation, and in experimental models of heart failure (HF), PKG1 activation by inhibiting cGMP degradation is protective. The net effect of the above-mentioned signalling is cardiovascular protection. Yet, while modulation of cGMP-PKG has entered clinical practice for treating pulmonary hypertension or erectile dysfunction, translation of promising studies in experimental HF to clinical success has failed thus far. With the advent of new technologies, novel mechanisms of PKG regulation, including mechanosensing, redox regulation, protein quality control, and cGMP degradation, have been discovered. These novel, non-canonical roles of PKG1 may help understand why clinical translation has disappointed thus far. Addressing them appears to be a requisite for future, successful translation of experimental studies to the clinical arena.
Doctors' Daughter
Authors: Stephanie Nagy-Agren
Journal: Annals of Internal Medicine (2000)

Letters18 April 2000Doctors' DaughterStephanie Nagy-Agren, MDStephanie Nagy-Agren, MDUniversity of Virginia Salem; Veterans Affairs Medical Center; Salem, VA 24153 (Nagy-Agren)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-132-8-200004180-00015 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:I was touched by Dr. McMurray's essay (1). It wasn't until after the birth of my second child 11 months ago that I developed real insight into what it means to be a “Dr. Mom.” Work continued nearly as usual after my first child. I was compulsive about my tasks, assumed additional clinical and teaching responsibilities, joined another committee, finagled in order to avoid taking sick leave.Life's routine became overwhelming with my second child even before I went back to work after 12 weeks' maternity leave. The experience of having two children crying at the same ...Reference1. McMurray JE. Doctors' daughter. Ann Intern Med. 1999;131:222-4. LinkGoogle Scholar Author, Article, and Disclosure InformationAuthors: Stephanie Nagy-Agren, MDAffiliations: University of Virginia Salem; Veterans Affairs Medical Center; Salem, VA 24153 (Nagy-Agren) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoDoctors' Daughter Julia E. McMurray Work–Family Balance Carole Warde Metrics Cited byTotal synthesis of FR901464: second generationWork–Family BalanceCarole Warde, MD 18 April 2000Volume 132, Issue 8Page: 676KeywordsAcademic medicineBirthChildrenFeversMedical servicesMotivation ePublished: 15 August 2000 Issue Published: 18 April 2000 Copyright & PermissionsCopyright © 2000 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
Hepatic resection in colorectal carcinoma and survival.
Authors: D E Bergsagel
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.11.2078 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 1941069 Hepatic resection in colorectal carcinoma and survival. D E BergsagelxD E BergsagelSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.11.2078 PDF "Hepatic resection in colorectal carcinoma and survival.." Journal of Clinical Oncology, 9(11), pp. 2078–2079© 1991 by American Society of Clinical Oncology
MB-80OUTCOME OF CHILDREN WITH POSTERIOR FOSSA MEDULLOBLASTOMA
Authors: David Sumerauer, Michal Zapotocky, Sona Cyprova, Josef Zamecnik, Bela Malinova, Ales Vicha, Ivana Pernikova, Barbora Ondrova, Martin Kyncl, Michal Tichy, Jan Stary
Journal: Neuro-Oncology (2016)
PML/Rara and Rara/PML Chimeric Genes On Derivative Chromosome 17 In a Patient With Acute Promyelocytic Leukemia With Atypical t(15;17)(q11;q21)
Authors: Pablo Lopez, Solange Simonet, Gerardo Romanelli, Daniela Infante, Analía Sanguinetti, Victoria V Elizondo, Isabel Moro, Cecilia Canessa, Lem Martinez, M. Rosario Uriarte Escuder, Rossana Bonomi
Journal: Blood (2013)
Effective targeting of tumor vasculature with an antibody against tumor endothelial marker 7-R (TEM7R).
Authors: M. Liu, J. Zhang, C. Shaller, H. Simmons, C. Bingham, M. K. Robinson, G. Adams, L. M. Weiner, H. Borghaei
Journal: Journal of Clinical Oncology (2011)

e13040 Background: Tumor associated blood vessels offer numerous tumor specific targets for therapy. St. Croix and colleagues reported the existence of novel genes expressed in human and murine tumor endothelium1,2. We report on the isolation, production and characterization of a single chain (scFv) and its corresponding IgG1 monoclonal antibody specific for murine TEM7R (mTEM7R) and present preliminary data that this antibody cross reacts with human TEM7R (hTEM7R). Methods: The cDNA encoding the extracellular domain (ECD) of mTEM7R was amplified by RT-PCR, cloned into the pSecTag2/Hygro A vector (Invitrogen) and stably transfected into HEK293 cells. A naïve human scFv phage display library comprised of 1010 independent clones3 was used to isolate scFv molecules reactive with mTEM7R. Using a solid phase panning strategy,4 we identified 5 families of anti-TEM7R scFv based on fingerprint analysis. Of the 5 families of scFv, 2 specifically bound to the mTEM7R ECD as confirmed by surface plasmon resonance (SPR) and by ELISA. One clone exhibited moderate affinity for purified ECD (10-8M) as measured by SPR and was chosen for further studies. This scFv was converted into a human IgG1 format by subcloning its Vh and Vl domains into the pMAZ-VH and pMAZ-Vl vectors (gift of Dr. Benhar, Tel-Aviv University), respectively. The resulting plasmids were co-transfected into HEK-T cells and the resulting IgG (BB1) was purified by Protein A affinity chromatography. Results: As measured by biodistribution and immuno-PET imaging studies, BB1 antibody demonstrated significant tumor uptake and prolonged tumor retention in SCID mice harboring s.c. tumor xenografts derived from five tumor cell lines of varying origin. Consistent with mTEM7R’s predicted vascular distribution, IHC and IF performed on fresh-frozen A431-derived tumor xenografts showed co-localization of BB1 and anti-CD31 antibodies to the tumor vasculature. In addition, BB1 demonstrated in vivo therapeutic efficacy against F9 (murine teratocarcinoma) and A431 tumor xenografts. Conclusions: The combined tumor targeting and therapeutic efficacy of BB1 antibody suggests TEM7R is a promising tumor vascular target and should be further investigated.
Response of a Localized Lymphocytic Neoplasm of the Mouse to 9&lt;italic&gt;α&lt;/italic&gt;-Fluorohydrocortisone and Related Steroids&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN2"&gt;3&lt;/xref&gt;
Authors: Julia McCain Lampkin-Hibbard
Journal: JNCI Journal of the National Cancer Institute (1960)

A lymphosarcoma was found to be highly sensitive to 9α-fluorohydrocortisone (9-AFH) and Decadron. Decadron and 9-AFH prolonged the life of animals bearing this neoplasm when given 24 hours after tumor inoculation or after the tumor had reached considerable size. In the 39th transfer generation, 30 percent of the mice treated with 25 mg. per kg. of 9-AFH for 5 days, starting on the 14th day after inoculation (established tumors 1.9 cm. in diameter), lived over 100 days without the neoplasm. Decadron was the most effective compound in increasing the survival time of tumor-bearing mice. When the dose of Decadron was 10 mg. per kg. for 10 consecutive days, 63 percent of the mice lived over 100 days. Prednisone was the next most effective steroid in causing regression of established tumors. This neoplasm was not as responsive to cortisone after the 38th transfer generation as it had been previously. Corticosterone was relatively inactive. A biological method for screening new steroid compounds in which the sensitive and resistant tumors are implanted in the same host is described. The cortisone-resistant subline is cross-resistant to 9-AFH, Decadron, and prednisone. The cortisone-resistant line of P1798 has remained resistant after serial transplantation for 40 transfer generations without cortisone.
HG-49A TEXAS-OKLAHOMA PEDIATRIC NEURO-ONCOLOGY CONSORTIUM (TOPNOC) PHASE 2 STUDY OF VALPROIC ACID (VPA) AND RADIATION, FOLLOWED BY MAINTENANCE VPA AND BEVACIZUMAB IN CHILDREN WITH NEWLY DIAGNOSED DIFFUSE INTRINSIC PONTINE GLIOMA (DIPG) OR HIGH-GRADE GLIOMAS (HGG)
Authors: Jack M. Su, Jeffrey C. Murray, Rene Y. McNall-Knapp, Daniel Bowers, Shafqat Shah, Adekunle M. Adesina, Arnold C. Paulino, Xiao-Nan Li, Eunji Jo, Qianxing Mo, Susan G. Hilsenbeck, Jeremy Y. Jones, Patricia A. Baxter, Murali Chintagumpala, Susan M. Blaney
Journal: Neuro-Oncology (2016)
Controlled Trial of Wireless Capsule Endoscopy versus Push Enteroscopy: Control Not Yet Perfect
Authors: M.  Bustamante, C.  Galvez, M.  D.  Higón, S.  Siles
Journal: Endoscopy (2004)

We read with great interest the article by Ell et al. on ”The first prospective controlled trial comparing wireless capsule endoscopy with push enteroscopy in chronic gastrointestinal bleeding” [1], and would like to make some comments on it. Previously, a randomized trial in dogs [2] and a few case reports [3] had suggested that capsule endoscopy is effective, but there had been a lack of substantial evidence for including the wireless capsule in the diagnostic work-up for patients with chronic gastrointestinal bleeding. Publication of a well-designed trial in patients with gastrointestinal bleeding was therefore eagerly awaited.
Seronegative polyarthritis.
Authors: A Rubens-Duval
Journal: BMJ (1981)

Where does this leave the coffee drinker-and his or her doctor when asked for advice ?At this stage alarm about the possible carcinogenicity of coffee is premature.As the authors themselves clearly state, the association they have discovered first needs to be confirmed by further studies and then shown to be causal.Recently two brief reports have appeared-of a prospective study that tentatively suggests an association2 and a case-control study that does not.3Further bulletins will be awaited with interest.
Delinking Investment in Antibiotic Research and Development from Sales Revenues: The Challenges of Transforming a Promising Idea into Reality
Authors: Kevin Outterson, Unni Gopinathan, Charles Clift, Anthony D. So, Chantal M. Morel, John-Arne Røttingen
Journal: PLoS Medicine (2016)

Kevin Outterson and colleagues outline a model to address access, conservation, and innovation of antibiotics.
Gastric Carcinoid Tumour as a Cause of Severe Upper Gastrointestinal Haemorrhage
Authors: H J Dallal, R Ravindran, P M King, P S Phull
Journal: Endoscopy (2003)

A 39-year-old woman was admitted on an emergency basis with severe upper gastrointestinal bleeding. On examination, she was shocked and had a haemoglobin of 37 g/l. Following resuscitation, she underwent an emergency upper gastrointestinal endoscopy, which showed a polypoid lesion in the antrum of the stomach (Figure [1]). As she remained unstable, a laparotomy was undertaken, at which the palpable lesion was identified (Figure [2]) and excised using an elliptical incision, with clear macroscopic margins. Pathological examination of the gastric tissue revealed a gastric carcinoid tumour (Figure [3]). The patient subsequently underwent a radical subtotal gastrectomy with Roux-en-Y gastrojejunal anastomosis. Histology showed that the resection margins were free from any tumour.
Value of Dimercaptosuccinic Acid Single Photon Emission Computed Tomography and Magnetic Resonance Imaging in Detecting Renal Injury in Pediatric Patients with Vesicoureteral Reflux
Authors: Masayuki Taleda, Katayama Katayama, Toshiki Tsutsui, Hitoshi Takahashi, Takeshi Komeyama, Takaki Mizusawa, Shotaro Sato
Journal: European Urology (1994)