tbuckley/cabot-search huggingface dataset:
FRI0032 Towards MRI Response Criteria for Rheumatoid Arthritis: Does the Course of Magnetic Resonance Imaging Predict Eular Response or Disease Progression?
Authors: P. Sewerin, C. Buchbender, F. Miese, S. Vordenbäumen, S. Klein, R. Brinks, G. Antoch, S. Matthias, O. Benedikt
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Objectives</h3> To define criteria based on the OMERACT rheumatoid arthritis MRI score (RAMRIS) which correspond to the 1-year EULAR response in a cohort of patients with rheumatoid arthritis. <h3>Methods</h3> 94 patients (62 female and 32 male patients) with rheumatoid arthritis from the Remission<sup>PLUS</sup> cohort starting with disease-modifying drugs or biologic agents and underwent low-field MR images of the dominant hand at baseline and after 12 months were included in this retrospective study. The 1-year treatment response was assessed by EULAR response criteria and OMERACT rheumatoid arthritis MRI score (RAMRIS). Spearman correlations between baseline and follow-up clinical (DAS28, CRP, ESR) and MRI findings (total RAMRIS, RAMRIS subscores) were calculated. Receiver operating curve analysis was performed to test if the 1-year EULAR response could be predicted by the change of the RAMRIS score from baseline- to follow-up MRI (ΔRAMRIS). <h3>Results</h3> After one year 51 patients (54.3%) showed a good, 22 (23.4%) a moderate and 18 (19.1%) a poor EULAR response. The correlations between clinical parameters and RAMRIS scores were weak at baseline and follow-up; the same was true for the score changes from baseline to follow-up. The likelihood of a good and poor EULAR response could be predicted by the ΔRAMRIS (<i>P</i> &lt;0.05). The AUC for the prediction of a good response and poor response was 0.63 and 0.71, respectively. The ΔRAMRIS values for 60, 70, 80, 90 and 99% probability for a good and poor response were -17, -35, -59, -93, -196 and 22, 29, 38, 50, 88, respectively. The probability of a moderate EULAR response could not be predicted by ΔRAMRIS (p=0.99). <h3>Conclusions</h3> The course of joint inflammation rated with the RAMRIS could predict the probability of a good and poor but not moderate therapy response according to the EULAR criteria. We propose the use of Δ RAMRIS thresholds to identify patients with a good or poor therapy response. These data provide the first step towards MRI response criteria in RA and need further evaluation and approval. <h3>Acknowledgements</h3> This study was supported by Abbott Immunology Germany (Dr. B. Wolff) and Esoate GmbH Deutschland (D. Pütz, W. van Kemenade). <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1725
Surgery of Elephantiasis of the Scrotum of Filarial Origin
Authors: Charles E. Towne
Journal: New England Journal of Medicine (1948)

A NEW interest in tropical diseases has been attained in American medicine because of the widespread contact with exotic diseases by troops in the worldwide conflict that terminated on V-J Day. Among these none is more bizarre than elephantiasis of Filaria (Wuchereria) bancrofti origin. This report deals with experience gained with this affliction among natives of Polynesian extraction in the Society Islands in French Oceania. I obtained the material for this paper in my capacity of chief of the Surgical Service of the 8th Station Hospital under the command of Lieutenant Colonel Julius Sobin, who performed the major part of . . .
Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome
Authors: H. Clifford Lane, Joel M. Depper, Warner C. Greene, Gail Whalen, Thomas A. Waldmann, Anthony S. Fauci
Journal: New England Journal of Medicine (1985)

Original Article from The New England Journal of Medicine — Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome — Evidence for a Selective Defect in Soluble Antigen Recognition
AB0343 Arthroscopic synovectomy for the rheumatoid elbow (short-term outcome)
Authors: A. Roskidaylo, M. Lipina, S. Makarov, M. Makarov, V. Amirdjanova
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> to evaluate effectiveness, the clinical outcomes and quality of life before and after arthroscopic synovectomy in patients with rheumatoid arthritis <h3>Methods</h3> Arthroscopic synovectomy of elbow was performed on in 21 patients with RA with radiographic changes of Larsen grade 3 or less. All patients had severe pain and swelling, resulting from acute or chronic synovitis, that had not responded to conservative treatment during 6 months. We performed total synovectomy of the elbow using multiple portals. Pain was evaluated with a visual analog scale and range of motion was measured. The Mayo Elbow Performance Score and Oxford Elbow Score was used to assess total elbow function; EQ-5D, HAQ – for evaluation quality of life <h3>Results</h3> The average age of patients was 40,5±13,25 years (18 to 57 years) and there was a 11 female and 10 male (1,1:1). There were 50% seropositive patients. The mean of follow up was 12.5±5,2 months (ranging from 7 to 22). The average duration of RA was 7,87±6,37 years. The average duration elbow complains 2,25±1,62 years. There were pain in 100% patients, synovitis and contrarture of elbow joint. The average increase in flexion was from 114,4° preoperatively to 127,5° at long term follow up and extension was from 27,5° preoperatively to 2,3° (p&lt; 0.05). The average increase in Mayo Elbow Score 48,75/93,12 and Oxford Elbow Score 18,5/8,87 on long term follow up (p &lt; 0.05). The mean EQ-5D (index) score improved from 0.23 to 0.72, HAQ from 1,59 to 0,84; VAS from 61,25 to 8,75. There was no neurovascular complication and infection, but in 6 cases (28,57%) were recurrent synovitis <h3>Conclusions</h3> Arthroscopic synovectomy of the elbow effectively relieve pain, increase range of motion and quality of life, improve Mayo and Oxford Elbow Score, although recurrent synovitis occurs in some patients <h3>References</h3> rheumatoid arthritis, arthroscopic synovectomy, elbow <h3>Disclosure of Interest</h3> None Declared
Abstract 1797: Differential gene expression profiles of FFPE samples with SensationPlus™ and GeneChip™ arrays.
Authors: Sangpen Chamnongpol, Andrea Ujvari, Olga Kourennaia, Kim Myers, Lisa Bowers, Jesse Fisher, Marc Post, Chris Kubu
Journal: Cancer Research (2013)

Abstract Formalin-fixed and paraffin-embedded (FFPE) tissue samples represent a largely untapped wealth of information on the transcriptional states of clinically archived materials for retrospective studies. Although the RNA is degraded during fixation and storage and has been considered unusable, Affymetrix has developed SensationPlus™, a target-preparation method that allows transcriptional profiling from 20 ng of FFPE total RNA using GeneChip™ arrays. We will demonstrate that SensationPlus™ expression profiles from decade old FFPE materials are extremely similar to data from their matched fresh frozen (FF) RNA counterparts. Citation Format: Sangpen Chamnongpol, Andrea Ujvari, Olga Kourennaia, Kim Myers, Lisa Bowers, Jesse Fisher, Marc Post, Chris Kubu. Differential gene expression profiles of FFPE samples with SensationPlus™ and GeneChip™ arrays. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1797. doi:10.1158/1538-7445.AM2013-1797
Increased Radiation Resistance of Breast Cancer Cells by Endocrine Disrupting Chemical Bisphenol A.
Authors: W. Kil, K. Camphausen
Journal: Cancer Research (2009)

Abstract Purpose: Bisphenol A (BPA) is used in the manufacture of plastics and belongs to a family of compounds called endocrine disrupting chemicals (EDCs). Because of extensive use of BPA in the manufacture of consumer goods and products, humans are exposed to levels of BPA which may cause adverse effects on endocrine-sensitive organs. Here, we evaluated the effects of BPA on the proliferation of breast cancer cells and the effect of BPA on tumor cell radioresponse.Materials/Methods: Proliferation was evaluated in estrogen-sensitive (MCF-7) and estrogen-insensitive (MDA-MB-231) human breast cancer lines that were treated for 72 hour with BPA (0.1µM; environmentally relevant concentration). The effect on radiation sensitivity was evaluated using clonogenic survival assays after exposure to various dose of BPA (0.1, 1, and 10 µM-) followed by irradiation (IR). DNA damage was evaluated using phosphorylated histone H2AX (γH2AX) and the neutral comet assay. BPA induced cell cycle changes were evaluated by staining of phosphor-H3 and flow cytomety. To investigate the mechanism of BPA±IR induced cell growth, we explored the activation of Akt and mitogen-activated protein kinase (MAPK) after treatments.Results: Exposure of BPA at low-dose (0.1µM) for 72 hour resulted in an increase survival rate in MCF-7 cancer cell (150 ± 19% of control) with more limited effects on MDA-MB-231 cancer cell (123 ± 17% of control). Exposure of MCF-7 to BPA for 72 hour before radiation resulted in an increase in radioresistance with dose-reduction factors at a surviving fraction of 0.1 of 1.23 and 1.31 with BPA 0.1µM, 10µM, respectively. BPA had no effect on the number of cells in each phase of the cell cycle nor on the activation of the G2 cell cycle checkpoint after IR. As a measure of DNA double strand breaks, γH2AX were determined as a function of time after the BPA±IR treatments. BPA also significantly decreased γH2AX expression at 24 hours after IR. Expression of phosphorylated Akt and phosphorylated mitogen-activated protein kinase (MAPK) increased with BPA± IR but decreased with IR alone at 24 hr.Conclusions: These results suggest that BPA can enhance phosphorylation of Akt and MAPK possibly leading to a resistance to radiation-induced cell death after IR. Further studies are needed to determine the clinical relevance of these findings. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 6073.
OP0008 Ultrasound in Gout: A Useful Tool for Follow-Up with Urate-Lowering Therapy
Authors: S. Ottaviani, G. Gill, A. Aubrun, E. Palazzo, O. Meyer, P. Dieudé
Journal: Annals of the Rheumatic Diseases (2014)

Article abstract—The authors studied the effect of bilateral subthalamic nucleus stimulation on levodopa-induced dyskinesias in 24 consecutive parkinsonian patients with disabling dyskinesias. The improvement in the three subtypes of levodopa-induced dyskinesias was significant from the third postoperative month and was mainly due to the decrease in the daily dose of levodopa allowed by the stimulation-induced improvement in the motor score.
Abstract LB-310: FISH-based determination of HER2 status in circulating tumor cells isolated with the microfluidic CEE™ platform
Authors: Julie A. Mayer, Tony J. Pircher, Stephen D. Mikolajczyk, Philip D. Cotter, Farideh Z. Bischoff
Journal: Cancer Research (2011)

Abstract Purpose: Determination of HER2 status by immunohistochemistry (IHC) and fluorescent in-situ hybridization (FISH) in patients with breast cancer is considered standard practice for selection of treatment options. Though patients presenting with recurrent and/or metastatic disease are often re-evaluated for HER2, biopsy is not often feasible. Thus, circulating tumor cells (CTCs) are an attractive alternative source of tumor tissue for determining HER2 status to enable a more effective course of treatment. Experimental Design: Twenty to thirty ml of peripheral blood was collected prospectively from 54 patients diagnosed with late stage metastatic/recurrent breast cancer. CTCs were isolated using the microfluidic CEE™ platform. CTC capture was achieved using a cocktail of capture antibodies, followed by detection with an expanded anti-cytokeratin (CK) cocktail mixture and anti-CD45. HER2 amplification was subsequently assessed by FISH on captured CK+/CD45− and CK−/CD45− cells. Results: CK+/CD45− cells were detected in 43 of 54 cases (80%). Among the 43 cases in which CK+ cells were detected, high concordance (93%) in HER2 status between primary tumor (by IHC and FISH) and CTCs (by FISH) was observed. An overall sensitivity of 95% and a specificity of 92% were obtained using the OncoCEE-BR™ assay. Conclusions: Recovery of CTCs from peripheral blood using the CEE™ platform is shown to be efficient and suitable for FISH-based testing. In addition, HER2 FISH on recovered CTCs is proven to be sensitive and accurate. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-310. doi:10.1158/1538-7445.AM2011-LB-310
P5-07-02: Could the Combination of COX-2 Inhibitor and Calcitriol Be a New Chemopreventive Approach To Decrease the Incidence of Breast Cancer?
Authors: M Thill, T Cordes, D Fischer, F Hoellen, M Friedrich, K Diedrich, C Dittmer
Journal: Cancer Research (2011)

Abstract Background COX-2 is a potential molecular prognostic factor for breast cancer and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is described as a tumour suppressor in cancer. The antiproliferative effects of calcitriol (1,25(OH)2D3) mediated via the vitamin D receptor (VDR) render vitamin D a promising target in breast cancer therapy. Material and Methods: The expression of the prostaglandin (PG) metabolising enzymes (COX-2, 15-PGDH), the PG receptors, the vitamin D metabolising enzymes (1-alpha-hydroxylase, 24-hydroxylase) and the VDR were determined in benign and malignant breast cell lines as well as in normal and malignant breast tissue. Measurement of PGE2 and 25(OH)2D3 serum level in healthy women and breast cancer patients was performed in winter and summertime. Additionally, the influence of calcitriol on cell proliferation was determined. In addition we examined the effect of calcitriol on the enzyme expression. Results: We found an inverse correlation between the expression of the PG metabolising enzymes with the VDR as well as with the vitamin D metabolising enzymes by investigating the tissue samples. Moreover, we detected an inverse correlation between the PGE2 and 25(OH)2D3 serum level in breast cancer patients during wintertime. Furthermore the PG receptors were associated with an increased carcinogenesis. The breast cell experiments presented a dysregulated vitamin D metabolism, especially in the invasive breast cell line. Calcitriol showed an antiproliferative effect only in the benign but not in the malignant cell lines, and the expression of COX-2 and 15-hydroxyprostaglandindehydrogenase was influenced by calcitriol only in the benign breast cell line. Conclusions: These results suggest a link between vitamin D and PG metabolism and therefore a possible synergism between COX-2 inhibition and calcitriol in breast cancer cells. For the first time, we could show an inverse correlation between the two metabolisms in breast cancer on different levels. Thus, the chemopreventive combination of calcitriol and/or vitamin D analogue with a COX-2 inhibitor might decrease the incidence of breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-07-02.
QUANTITATIVE ASSESSMENT OF REGIONAL CEREBRAL BLOOD FLOW WITH SPECT USING Tc99m-HMPAO: A COMPARISON TO CT AND MRI.
Authors: Karen Garret, John Kuperus, Aaron Peretz, Bruce Miller, Ismael G. Mena
Journal: Clinical Nuclear Medicine (1987)

Garret, Karen; Kuperus, John; Peretz, Aaron; Miller, Bruce; Mena, Ismael G. Author Information
α-Satellite DNA and Vector Composition Influence Rates of Human Artificial Chromosome Formation
Authors: Brenda R. Grimes, Angela A. Rhoades, Huntington F. Willard
Journal: Molecular Therapy (2002)

Human artificial chromosomes (HACs) have been proposed as a new class of potential gene transfer and gene therapy vector. HACs can be formed when bacterial cloning vectors containing alpha-satellite DNA are transfected into cultured human cells. We have compared the HAC-forming potential of different sequences to identify features critical to the efficiency of the process. Chromosome 17 or 21 alpha-satellite arrays are highly competent HAC-forming substrates in this assay. In contrast, a Y-chromosome-derived alpha-satellite sequence is inefficient, suggesting that centromere specification is at least partly dependent on DNA sequence. The length of the input array is also an important determinant, as reduction of the chromosome-17-based array from 80 kb to 35 kb reduced the frequency of HAC formation. In addition to the alpha-satellite component, vector composition also influenced HAC formation rates, size, and copy number. The data presented here have a significant impact on the design of future HAC vectors that have potential to be developed for therapeutic applications and as tools for investigating human chromosome structure and function.
Abstract P3-11-12: Influence of Hormone Therapy Prior to Breast Cancer Diagnosis on Prognosis of Postmenopausal and Perimenopausal Breast Cancer Patients
Authors: AK Baumgaertner, A Haeusler, VR Seifert-Klauss, T Schuster, U Schwarz-Boeger, Klinikum Kiechle M.
Journal: Cancer Research (2010)

Abstract Introduction: Use of hormone therapy (HT) has been associated with higher incidence of hormone receptor positive breast cancer in postmenopausal women. However, it is unclear if breast cancers developing after HT use are different in course of disease and prognosis from tumors growing without prior exogenous hormone use. Methods: Women with hormone receptor positive breast cancer diagnosed between 1984 and 2006 at our university breast cancer center (n=1247) were analyzed in a single-center retrospective trial. Outcome data comparing overall survival, local and distant recurrence were extracted from the hospital cancer data base and the local breast cancer registry, as well as from primary care-giving gynecologists and by review of patient charts. Cases were stratified according to hormone therapy use before breast cancer diagnosis. This is the first analysis differentiating between perimenopausal and postmenopausal patients. Results: 1053 patients with hormone receptor positive non-metastasized invasive breast cancer were included in the final analysis. 198 (18.8%) women were premenopausal, 126 (12.0%) were perimenopausal and 729 (69.2%) were postmenopausal. Information on former HT use was available for 933 (88.6%) patients. 542 (51.4%) patients had never used HT, including 194 premenopausal patients. 324 (44.4%) postmenopausal and 67 (53.2%) perimenopausal women had used HT before breast cancer diagnosis. At time of first diagnosis there was a significantly higher rate of early stage and nodal negative disease in postmenopausal HT users versus non users (P&amp;lt;0.01 and p=0.02 respectively). In multivariate analysis, HT use prior to diagnosis in postmenopausal patients resulted in longer time to progression and longer overall survival (RR 0.84 and RR 0.70 with p=0.34 and p=0.07 respectively). In perimenopausal patients however, HT use prior to breast cancer diagnosis was associated with shorter time to progression and overall survival (RR 2.41 and RR 3.32 with p=0.99 and p=0.05 respectively). Higher BMI in perimenopausal women had a significant influence on prognosis with RR=1.14 for TTP and RR=1.23 for OS, whereas it had no effect in the postmenopausal group. Conclusion: According to this retrospective analysis, hormone therapy prior to breast cancer diagnosis has different effects on outcome parameters depending on patients’ menopausal state. Whereas in postmenopausal patients HT was associated with better prognosis, in perimenopausal women it might have detrimental effect. Citation Information: Cancer Res 2010;70(24 Suppl):Abstract nr P3-11-12.
LONG-TERM PREDICTION OF ALL-CAUSE MORTALITY AND MYOCARDIAL INFARCTION USING QUANTIFIED CORONARY PLAQUE VOLUME AND HIGH-RISK PLAQUE FEATURES
Authors: Simon Deseive, Ramona Straub, Maximilian Kupke, Martin Hadamitzky, Pieter Kitslaar, Alexander Broersen, Steffen Massberg, Joerg Hausleiter
Journal: Journal of the American College of Cardiology (2016)
Barium Concretion Causing Obstipation
Authors: Nirav Thosani, David S Wolf
Journal: New England Journal of Medicine (2014)

A 39-year-old woman with a history of severe scleroderma presented with nausea, vomiting, abdominal pain, and obstipation 7 days after an upper-gastrointestinal series with barium contrast. A video shows removal of a 5-cm barium concretion in the proximal sigmoid colon.
P15.03 * CARER PERCEPTIONS OF THE END OF LIFE PHASE IN MALIGNANT GLIOMA IN SOUTH EAST SCOTLAND
Authors: S. McNamara, J. C. Day, S. Erridge, S. Peoples, R. Grant
Journal: Neuro-Oncology (2014)

INTRODUCTION: Little is known about Health-Related Quality of Life of glioma patients during the end-of-life-phase of care. During this time, patients may experience a number of neurological and cognitive deficits, changes in personality, epilepsy, side-effects of medication, fatigue and depression. To explore this, carer perceptions of the level of disability and quality of care in the end of life phase of patients with high grade glioma were explored at 3 months and 1 week before the death of the patient. METHODS: A retrospective descriptive study of General Practitioners (GP) and relatives of deceased patients diagnosed between 2008 and 2009 was carried out in South East Scotland. Questionnaires relating to symptoms, quality of life, health care provision, place of care, patient's wishes and end-of-life care were sent to GPs and relatives following the death. Patient demographics and tumour details were extracted from case records where available. RESULTS: 110 relatives were sent questionnaires 52 (46%) relatives responded. Relatives stated that at 3 months headache was the most reported symptom (56%), followed by seizures (40%) and hemiparesis (29%), whereas at 1 week prior to death, fatigue was the most common symptom (71%), followed by nausea/vomiting (63%) and confusion (42%). Eighty percent of patients used a stick, or were wheelchair or bedbound at 3 months whereas, 90% were confined to their bed and 94% required assistance 1 week prior to death Approximately 1 in five patients had seizures at least weekly at 3 months and also in the last week of life. Main issues that affected dignity of death included communication problems (50%) cognitive issues (44%) or inability to care for themselves. Sixty two percent of relatives felt that symptoms were treated effectively. Most relatives felt they had enough information provided by the health care professionals (86%), that they were involved in decision making (92%), and agreed with the decisions made (84.5%). Further, only 14% were dissatisfied with their role as caregiver at the end of life, but more than half felt there was insufficient psychological support for them. Thirty seven percent of patients had a living will and in the last week the majority of patients did not have capacity. Overall, 20 (38%) patients died in hospice; 17 (33%) died at home; 12 (23%) died in hospital; 2(4%) died in a nursing home and 1(2%) died elsewhere. CONCLUSIONS: Most relatives were satisfied with both their role as caregiver, and the involvement in decision making about the patient's care. Advanced care planning needs to be encouraged early in the disease process. Relatives felt that there was scope for better symptom control and there was insufficient psychological support for themselves.