tbuckley/cabot-search huggingface dataset:
Treatment of High-Risk Neuroblastoma with Intensive Chemotherapy, Radiotherapy, Autologous Bone Marrow Transplantation, and 13-<i>cis</i>-Retinoic Acid
Authors: Katherine K. Matthay, Judith G. Villablanca, Robert C. Seeger, Daniel O. Stram, Richard E. Harris, Norma K. Ramsay, Patrick Swift, Hiroyuki Shimada, C. Thomas Black, Garrett M. Brodeur, Robert B. Gerbing, C. Patrick Reynolds
Journal: New England Journal of Medicine (1999)

Children with high-risk neuroblastoma have a poor outcome. In this study, we assessed whether myeloablative therapy in conjunction with transplantation of autologous bone marrow improved event-free survival as compared with chemotherapy alone, and whether subsequent treatment with 13-cis-retinoic acid (isotretinoin) further improves event-free survival.
Hypoglycemia Associated with Non-Islet-Cell Tumor and Insulin-like Growth Factors
Authors: Phillip Gorden, Carla M. Hendricks, C. Ronald Kahn, Klara Megyesi, Jesse Roth
Journal: New England Journal of Medicine (1981)

THE syndrome of hypoglycemia associated with large non-islet-cell tumors is well known.1 2 3 We have previously used a radioreceptor assay to demonstrate that some of these patients have elevated plasma concentrations of an insulin-like growth factor.4 5 6 In contrast to patients with islet-cell tumors, these patients do not have elevations of immunoreactive insulin in plasma. In this report we identify the types of tumors that were most frequently associated with elevations of this insulin-like growth factor in serum from 52 patients; in addition we describe the relation of this insulin-like growth factor to successful therapy in one patient.MethodsSerum or heparinized . . .
1135 IL28B CC GENOTYPE IS ASSOCIATED WITH HIGHER ON-TREATMENT-RESPONSE RATES IN PTS WITH HCV-3: INTERIM RESULTS OF THE WRITE STUDY
Authors: V. Piazzolla, P. Forte, R. Francavilla, G. Barbarini, F. Mecenate, M. Carrado, N. Minerva, D. Bacca, V. Carretta, A. Pellicelli, M. Romano, G. Montalto, L. Zignego, L. Nosotti, A. De Luna, E. Agostinacchio, G. Cuccorese, S. Luchi, G. Bertino, R. Santoro, L. Mottola, D. Petruzzellis, D. Facciorusso, A. Mangia
Journal: Journal of Hepatology (2012)
THU0578 The Patient’s View on Rheumatology Nursing Care: Results of a Survey
Authors: Y. Van Eijk-Hustings, J. Ammerlaan, H. Voorneveld, C. Veldhuizen, H. Repping-Wuts
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> In order to minimise differences in rheumatology nursing care across countries and regions, recommendations for the role of the nurse have been developed (1). However, patients should be directional in defining the content of good quality care. Therefore, their expectations and needs were explored in focus groups. 4 main themes were categorised: education, self-management support, emotional support and well-organised care. <h3>Objectives</h3> The objective of the present study was to explore 1) the importance of the themes among a larger group of patients 2) patient satisfaction with the care that is provided and 3) patients' preferences for methods of care delivery. <h3>Methods</h3> Dutch patients were invited to participate in a web-based survey. The survey presented topics for each theme. Patients had to select the most appropriate answer. For each topic, patients had to select 1 out of 5 categories for importance (not at all/somewhat no/somewhat yes/very/do not know). Regarding education, patients also had to give their satisfaction, by whom they would like to receive care and by what method. <h3>Results</h3> In total 475 patients, with systemic inflammatory diseases such as RA (76%), and other disorders such as OA (24%), filled in the questionnaires. Mean age was 56 years, mean disease duration was 13 years, and 72% were female. The topics of most importance are presented in the table. <h3>Conclusions</h3> The survey yielded valuable information about the importance of topics for education, self-management support, emotional support and care organisation but also about patients' opinions about care delivery. The results can support monitoring of the quality of care from a patient's perspective. <h3>References</h3> van Eijk-Hustings Y, van Tubergen A et al. EULAR recommendations for the role of the nurse in the management of chronic inflammatory arthritis. Ann Rheum Dis. 2012;71 (13-19). <h3>Acknowledgements</h3> We would like to thank our patient research partners for their valuable contribution to this study. <h3>Disclosure of Interest</h3> None Declared
Science Recruiting Getting Aggressive: The Competition for Top Researchers
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Science Recruiting Getting Aggressive: The Competition for Top Researchers Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 1, January 1989, Pages 4–5, https://doi.org/10.1093/jnci/81.1.4 Published: 01 January 1989
Secular Trends in Histologic Types of Lung Cancer
Authors: A H Wu, B E Henderson, D C Thomas, T M Mack
Journal: JNCI Journal of the National Cancer Institute (1986)

The histology pattern of lung cancer in Los Angeles County was reviewed for a 10-year period, 1972-81. In men, the total lung cancer incidence has been fairly constant, but there has been a shift in the histology pattern with an increase in adenocarcinoma and a decrease in "other" cell type (i.e., carcinoma not otherwise specified, large-cell and undifferentiated tumors). This changing histology pattern may be partly due to changes in diagnostic standards and practices. With the assumption that these changes are comparable in men and women, the "true" annual rate of change was estimated for each lung cancer cell type in women. All lung cancer types have increased in women; of the cell types squamous cell carcinoma, small-cell carcinoma, and adenocarcinoma, small-cell carcinoma showed the largest rate of annual increase and adenocarcinoma, the smallest.
Gawin J S Herdman
Authors: G. B. Ackermann
Journal: BMJ (2012)

Former general practitioner (b 1923; q Bristol 1946; DRCOG), d 28 January 2012.

Gawin J S Herdman was born in Newquay, Cornwall. He did his National Service in East Africa in 1947-8. He loved obstetrics, but after …
ANTITHYMOCYTE GLOBULIN INDUCTION THERAPY IN CARDIAC TRANSPLANTATION IS ASSOCIATED WITH DECREASED CORONARY PLAQUE PROGRESSION
Authors: Christopher Vanichsarn, Richard Cheng, Babak Azarbal, Michelle Kittleson, Lawrence Czer, Jignesh Patel, Jon Kobashigawa
Journal: Journal of the American College of Cardiology (2015)
Abstract 2148: Thalidomide and liposomal doxorubicin inhibit differentiation and function of human osteoclasts
Authors: Yu-Jen Chen, Yu-Yawn Chen, Chih-Wen Chi, Hui-Fen Liao
Journal: Cancer Research (2011)

Abstract Background: Thalidomide inhibits angiogenesis and growth of multiple myeloma. Liposomal doxorubicin is mainly absorbed and degraded by monocyte-macrophage lineage in vivo, implicating a possible targeting effect. Given that osteoclasts (OCs) are derived from precursors of monocyte-macrophage lineage, we hypothesized that thalidomide, liposomal doxorubicin and their combination may affect osteoclastogenesis. Materials and Methods: We isolated CD14+ monocytes from peripheral blood mononuclear cells of healthy subjects and generated OCs under stimulation with macrophage-colony forming factor and receptor activator of NK-κB ligand. Cell viability, surface CD51/61 expression, and tartrate-resistant acid phosphatase (TRAP) activity were assessed by using MTT, flow cytometry and immunohistochemical staining, respectively. Bone resorption activity of OCs was examined. Results: The combination of thalidomide (purchased from TTY Biopharm, Taiwan) and liposomal doxorubicin (purchased from TTY Biopharm, Taiwan) profoundly inhibited the amount of harvested viable OCs. The expression of osteoclast-specific surface antigen CD51/61 was markedly inhibited by each drug and their combination. Specifically, the amount of multinucleated TRAP-positive cells characteristics of OCs and bone resorption activity of OCs were suppressed by each drug and, the mostly, their combination. Conclusion: Thalidomide, liposomal doxorubicin and their combination, beyond currently clinical indications, might be effective regimen to inhibit human osteoclastogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2148. doi:10.1158/1538-7445.AM2011-2148
National Statistics Source Reaches 20th Anniversary
Authors: T. Reynolds
Journal: JNCI Journal of the National Cancer Institute (1993)

Journal Article National Statistics Source Reaches 20th Anniversary Get access Tom Reynolds Tom Reynolds Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 85, Issue 23, 1 December 1993, Pages 1897–1899, https://doi.org/10.1093/jnci/85.23.1897 Published: 01 December 1993
Clinical Outcomes after Hepatitis C Infection from Contaminated Anti-D Immune Globulin
Authors: Elizabeth Kenny-Walsh
Journal: New England Journal of Medicine (1999)

In February 1994, batches of anti-D immune globulin used in Ireland during 1977 and 1978 to prevent Rh isoimmunization were found to be contaminated with hepatitis C virus (HCV) from a single infected donor. In March 1994, a national screening program was initiated for all women who had received anti-D immune globulin between 1970 and 1994. Of the 62,667 women who had been screened when this study began, 704 (1.1 percent) had evidence of past or current HCV infection, and 390 of those 704 (55 percent) had positive tests for serum HCV RNA on reverse-transcription-polymerase-chain-reaction analysis. All 390 were offered a referral for clinical assessment and therapy. We evaluated 376 of these 390 women (96 percent); the other 14 were not seen at one of the designated treatment centers.The mean (+/-SD) age of the 376 women was 45+/-6 years at the time of screening. They had been infected with hepatitis C for about 17 years. A total of 304 women (81 percent) reported symptoms, most commonly fatigue (248 [66 percent]). Serum alanine aminotransferase concentrations were slightly elevated (40 to 99 U per liter) in 176 of 371 women (47 percent), and the concentrations were 100 U per liter or higher in 31 (8 percent). Liver biopsies showed inflammation in 356 of 363 women (98 percent); in most cases the inflammation was slight (41 percent) or moderate (52 percent). Although the biopsy samples from 186 of the 363 women (51 percent) showed evidence of fibrosis, only 7 women (2 percent) had probable or definite cirrhosis. Two of the seven reported excessive alcohol consumption.Most of the women with HCV infection 17 years after receiving HCV-contaminated anti-D immune globulin had evidence of slight or moderate hepatic inflammation on liver biopsy, about half had fibrosis, and 2 percent had probable or definite cirrhosis.
Case 26-2008
Authors: Thomas D. Sabin, Jeffrey A. Jednacz, Paul N. Staats
Journal: New England Journal of Medicine (2008)

A 26-year-old woman was admitted to this hospital because of headache, behavioral changes, abnormal movements, and inability to communicate. Seven weeks before admission, headaches developed, followed by somnolence, mood alteration, confusion, memory loss, incoherent speech, and involuntary movements. An evaluation for infection was negative. Imaging studies showed a normal brain and an ovarian mass consistent with a dermoid cyst. A diagnostic procedure was performed.
SAFETY AND EFFICACY OF BIORESORBABLE VASCULAR SCAFFOLDS VERSUS METALLIC EVEROLIMUS-ELUTING STENTS IN CORONARY ARTERY DISEASE: A WEIGHTED META-ANALYSIS OF 6 RANDOMIZED CONTROLLED TRIALS ENROLLING 3,733 PATIENTS
Authors: Joelle Elias, Robin P. Kraak, Mariella Hassell, Joanna J. Wykrzykowska, Robbert de Winter, Jan Piek, José Henriques, Bimmer Claessen
Journal: Journal of the American College of Cardiology (2016)
Symptomatic Toxicities Experienced During Anti-Cancer Treatment: Comparison of Patients' and Physicians' Reporting in Three Randomized Controlled Trials (Rcts)
Authors: M. Di Maio, M.C. Piccirillo, G. Daniele, F. Nuzzo, C. Gridelli, V. Gebbia, F. Ciardiello, S. De Placido, A. Ceribelli, A. Favaretto, A. De Matteis, R. Feld, C.A. Butts, N.B. Leighl, A. Morabito, J. Bryce, S. Signoriello, C. Gallo, F. Perrone
Journal: Annals of Oncology (2014)
German Outbreak of<i>Escherichia coli</i>O104:H4 Associated with Sprouts
Authors: Udo Buchholz, Helen Bernard, Dirk Werber, Merle M Böhmer, Cornelius Remschmidt, Hendrik Wilking, Yvonne Deleré, Matthias an der Heiden, Cornelia Adlhoch, Johannes Dreesman, Joachim Ehlers, Steen Ethelberg, Mirko Faber, Christina Frank, Gerd Fricke, Matthias Greiner, Michael Höhle, Sofie Ivarsson, Uwe Jark, Markus Kirchner, Judith Koch, Gérard Krause, Petra Luber, Bettina Rosner, Klaus Stark, Michael Kühne
Journal: New England Journal of Medicine (2011)

A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany in May 2011. The source of infection was undetermined.We conducted a matched case-control study and a recipe-based restaurant cohort study, along with environmental, trace-back, and trace-forward investigations, to determine the source of infection.The case-control study included 26 case subjects with the hemolytic-uremic syndrome and 81 control subjects. The outbreak of illness was associated with sprout consumption in univariable analysis (matched odds ratio, 5.8; 95% confidence interval [CI], 1.2 to 29) and with sprout and cucumber consumption in multivariable analysis. Among case subjects, 25% reported having eaten sprouts, and 88% reported having eaten cucumbers. The recipe-based study among 10 groups of visitors to restaurant K included 152 persons, among whom bloody diarrhea or diarrhea confirmed to be associated with Shiga-toxin-producing E. coli developed in 31 (20%). Visitors who were served sprouts were significantly more likely to become ill (relative risk, 14.2; 95% CI, 2.6 to ∞). Sprout consumption explained 100% of cases. Trace-back investigation of sprouts from the distributor that supplied restaurant K led to producer A. All 41 case clusters with known trading connections could be explained by producer A. The outbreak strain could not be identified on seeds from the implicated lot.Our investigations identified sprouts as the most likely outbreak vehicle, underlining the need to take into account food items that may be overlooked during subjects' recall of consumption.
Glutamate carboxypeptidase II inhibition IN rat models of chemotherapy-induced peripheral neurotoxicity (CIPN)
Authors: V. A. Carozzi, A. Canta, J. Konvalinka, B. Slusher, K. Wozniak, R. Lapidus, G. Cavaletti
Journal: Journal of Clinical Oncology (2008)

9558 Background: Excessive glutamate release is associated with neuronal damage. Inhibition of Glutamate Carboxypeptidase II (GCPII) decreases excitatory glutamate levels and it is neuroprotective in several disorders of the central and peripheral nervous system. Methods: This study had the following aims: to investigate the neuroprotective effect of GCPII inhibitor GPI 16072 at doses ranging from 0.1 to 10 mg/kg/day in cisplatin, oxaliplatin, docetaxel, paclitaxel+cisplatin and bortezomib-induced peripheral neuropathies in rodents through electrophysiological evaluations (NCV), morphologic and morphometric analysis of Dorsal Root Ganglia (DRG) and sciatic nerve; to determine the expression and the distribution of GCPII in DRG and sciatic nerve in order to identify molecular mechanisms of neuroprotection. Results: Electrophysiological analysis demonstrated that drug-induced NCV reduction is significantly counteracted by the co- administration of GPI 16072 in all the animal models. DRG morphometric analysis showed that GPI 16072 10 mg/Kg induced a significant protection against Cisplatin and Paclitaxel+Cisplatin-induced neuronal atrophy. In addition, GPI 16072 did not interfere with the antineoplastic efficacy of oxaliplatin at doses which were neuroprotective. To interpret these results, molecular studies showed that GCPII is expressed both in DRG and in sciatic nerve and it is localized in the cytoplasm of satellite cells in the DRG and in the outer cytoplasm of Schwann cells in sciatic nerve. Conclusions: This study provides evidence for a neuroprotective role of GCPII inhibition in several chronic chemotherapy- induced periheral neuropathies models and provides support for GPI 16072 being an attractive candidate for clinical treatment of these pathologies. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration MGI Pharma, Baltimore MGI Pharma, Baltimore
Commentary: Perspective on Chemicals and Health
Authors: Robert Eckardt
Journal: Environmental Health Perspectives (1975)

It seems to me that what we are attempting at this meeting is an evaluation of the potential health hazards of plastics (or polymers) and their precursors (monomers), catalysts, and additives. These health hazards run the gamut from well-recognized, requiring some degree of control, to the purely speculative, where the necessity for control may be open to considerable discussion and debate. Obviously the degree of control necessary even in those cases where it is obvious that some control is necessary can also lead to honest differences of opinion which in turn can lead to discussion and debate. It would appear that at our level this discussion and debate should be as unimpassioned and objective as we can make it. I think it might behoove all of us to read the Report of the Panel on  and Health of the President's Science Advisory Committee, entitled Chemicals and Health, dated September 1973. That report contains some very interesting and illuminating discussions which help us to keep our own thinking in an appropriate perspective. For instance the Panel poses the question, What adverse impacts do uses of chemicals exercise on man's health today? The Panel then proposes that the firmest basis for answering this question is to begin from estimates of death linked to chemical causes. Even acknowledging all of the inaccuracies inherent in such estimates, the Panel concludes that even if each such estimate
Phase I study of the oral CDK-TRKA inhibitor PHA-848125 in combination with gemcitabine in advanced solid tumors.
Authors: R. Bahleda, A. Spreafico, J. Soria, C. Moldovan, C. Belli, F. Fiorentini, A. Scaburri, M. A. Pacciarini, B. Laffranchi, M. Reni
Journal: Journal of Clinical Oncology (2010)

3063 Background: PHA-848125 (PHA) is a dual CDK/TRKA oral inhibitor showing significant single agent antitumor activity in several tumor models including pancreas (tumor growth inhibition range 65-74% in 3 pancreatic ca. xenograft models), prostate, lung, ovarian and glioma. In combination with gemcitabine (G), PHA exhibits synergistic effects in vitro and additive activity in the BX-PC3 human pancreatic ca. xenograft, at well tolerated doses. Methods: Phase I study to determine safety, pharmacokinetics (PK) and recommended dose for phase II (RP2D) of PHA/G combination in patients (pts) with advanced solid tumors. Cohorts of 3-6 pts received iv G on d1, 8, 15 and oral PHA once daily 7 days on/ 7 days off, in 4-week cycles (cy). At the fixed G dose of 1,000 mg/m2, PHA doses investigated were: 45 mg/m2 (3 pts), 60 mg/m2 (3 pts) and 80 mg/m2, the RP2D as a single agent (10 pts). Results: Sixteen pts (lung 5, mesothelioma 3, pancreas, prostate, colorectal 2 each, thymoma 1, thyroid 1) were treated for a total of 65+ cys (median 4, range 1-8+), with 6 pts receiving 6 cys or more. Drug-related side effects were mainly nausea (max grade [gr] 2), vomiting (max gr 3), diarrhea (max gr 2), thrombocytopenia (max gr 4), neutropenia (max gr 3), asthenia (max gr 2). Ataxia gr 3 and tremor gr 2 (1 pt) are in line with the PHA toxicity pattern. PHA 80/G 1,000 mg/m2 was considered as the RP2D, with 1 DLT (gr 4 thrombocytopenia) in 1/9 evaluable pts. At RP2D, median cy 1 dose administered was 83% for G (range 67-100%) and 100% for PHA (range 50-100%), dose reductions mainly due to thrombocytopenia gr 2-3 or neutropenia gr 2-3. Stable disease for ≥ 4 cycles was observed in 8 pts. One pt with NSCLC, progressing after G-based chemotherapy, showed a 42% reduction in target lesions. Preliminary data indicate no difference in PK parameters when PHA is given in combination with G, with exposures increasing with dose. Updated safety, efficacy and PK data will be reported. Conclusions: PHA/G combination is feasible, with no overlapping toxicity at doses recommended for each drug given as single agents. RP2D is PHA 80/G 1,000 mg/m2. This regimen showed clinical activity in various solid tumors including pancreas, prostate, mesothelioma, and NSCLC. Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Accelera, Nerviano Medical Sciences
Collagenous Sprue — An Unrecognized Type of Malabsorption
Authors: W. M. Weinstein, D. R. Saunders, G. N. Tytgat, C. E. Rubin
Journal: New England Journal of Medicine (1970)

Collagenous sprue is a distinctive lesion of the intestinal mucosa associated with progressive malabsorption. The intestinal pathology, as observed in a 51-year-old woman, was initially identical with the characteristic "flat" lesion of untreated celiac sprue. Thereafter, bands of eosinophilic hyaline material within the lamina propria became increasingly apparent. On electron microscopy this eosinophilic material was identified as collagen. As the disease progressed, the mucosa became progressively thinner. Nevertheless a few short segments of normal mucosa remained even at the time of death. Massive steatorrhea, water and electrolyte loss were the main problems. Corticosteroids reduced malabsorption somewhat but had deleterious side effects. All other therapy, including a gluten-free diet, failed. Extensive studies during life and careful post-mortem examination did not establish a known cause for collagenous sprue. Some cases currently designated "refractory" or "unclassified" sprue may prove to be collagenous sprue.