tbuckley/cabot-search huggingface dataset:
Abstract A01: Innate lymphoid cells (ILCs) in murine melanoma: A new paradigm in cancer immunity
Authors: Blake Christianson, James Walker, Marsha Kocherla, Xu Qin, Jack C. Yu, Babak Baban
Journal: Cancer Research (2016)

Abstract Introduction: Innate lymphoid cells (ILCs), have emerged as novel important immune effector cells, playing a critical role also in tumor immune-surveillance. Recently, it was shown that the number of ILCs in patients with different types of cancer is significantly reduced after chemotherapy/radiotherapy as compared to healthy donors. However, so far, no data on ILC frequency, subset distribution and function in patients with melanoma are available. Therefore, we analyzed the frequency, subset distribution and function of ILCs in a murine model of melanoma with/without treatment, a parameter that is of paramount importance to understand the role of ILCs during melanoma and to assess the impact of current treatments on this type of cancer. Methods: C57/BL6 mice were injected with B16F10 murine melanoma cell line (1 x 106 cells/mouse, subcutaneous). Tumor growth monitored. Once tumors reached 12mm in size, the mice were sacrificed and tumor cells subjected to flow-cytometry and cell culture to identify the ILC subclasses in the tumor. Results: Our findings establish, for the first time in melanoma at diagnosis, base-line reference values for ILC frequency and function, as well as the ILC subtype distribution. Conclusion: Our studies extend previously published work on changes in innate lymphoid cells. Our findings will help better understanding of tumor microenvironment and its interaction with immune system. These values indicate the potential of ILCs as crucial players in the treatment of cancer, specifically melanoma. Citation Format: Blake Christianson, James Walker, Marsha Kocherla, Xu Qin, Jack C. Yu, Babak Baban. Innate lymphoid cells (ILCs) in murine melanoma: A new paradigm in cancer immunity. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr A01.
Abstract A26: Importance of long noncoding RNAs in human papillomavirus-related cancers
Authors: Jamie A. Barr, Karen E. Hayes, Ivan Martinez
Journal: Cancer Research (2016)

Abstract The objective of this study is to identify the importance of long non-coding RNAs (lncRNAs) in the induction of carcinogenesis by high-risk human papillomavirus (HPV)-16 oncoprotein E6 in HPV-related cancers. Dysregulation of long non-coding RNAs (lncRNAs) occurs in most human cancers, however, there are only a few studies showing dysregulation of specific lncRNAs in human papillomavirus (HPV)-related cancers. High-risk HPV infection (e.g. HPV-16 and HPV-18) is one the most common causes of cervical cancer, as well as a subset of head and neck squamous cell carcinoma (HNSCC). It is well known that one of the main factors contributing to HPV-related carcinogenesis is the expression of high-risk HPV E6 viral oncoprotein and its interaction with several human proteins, such as the tumor suppressor p53 and the anti-apoptotic protein Bak. It is hypothesized that HPV-16 E6 changes the expression of host lncRNAs to regulate downstream processes important in the induction of carcinogenesis. To test this hypothesis, we stably express high-risk HPV-16 E6 in primary human keratinocytes and conducted high-throughput RNA sequencing analysis to identify HPV-16 E6-mediated changes in lncRNAs expression. Our preliminary data shows over 500 lncRNAs up- or down- regulated by greater than 2-fold with the expression of HPV-16 E6 compared to control. We validated the expression changes of many individual lncRNAs after the expression of HPV-16E6, via q-RT-PCR and Northern blots. In addition we observe similar expression patterns when comparing normal cells to HPV+ cervical cancer cell lines. Currently, we are characterizing specific lncRNAs of interest that are altered with expression of HPV-16 E6 by using 5' and 3' rapid amplification of cDNA ends (RACE) experiments as well as determining certain lncRNA's mechanism of action contributing to cancer by conducting knockdown and rescue experiments followed by behavior assays (e.g. invasion, angiogenesis, and proliferation). To aid in the determination of the function of the lncRNAs, we plan to use Fluorescence in situ Hybridization (FISH) assays to identify their localization. We believe this project will be significant in that it will identify and show the importance of lncRNAs in HPV-related cancers as well as give us new information about a novel mechanism by which high-risk HPV infection contributes to cervical and HNSCC carcinogenesis. Citation Format: Jamie A. Barr, Karen E. Hayes, Ivan Martinez. Importance of long noncoding RNAs in human papillomavirus-related cancers. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr A26.
Decision-Making At The End Of Consolidation Of Acute Myeloid Leukemia: Negative Effect Of Minimal Residual Disease Detectable With Multiparametric Flowcytometry Combined With Gene Mutations Of FLT3 On Early Relapse
Authors: Yuichiro Ono, June Takeda, Hayato Maruoka, Yasuhiro Kazuma, Nobuhiro Hiramoto, Nobuhiko Yamauchi, Yosuke Nagahata, Yuki Funayama, Yotaro Ochi, Yusuke Koba, Sumie Tabata, Noboru Yonetani, Akiko Matsushita, Koji Nasu, Takayuki Takahashi, Hisako Hashimoto, Takayuki Ishikawa
Journal: Blood (2013)
Ethics in oncology textbooks.
Authors: G B Weiss, H Y Vanderpool
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.10.1432 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4045530 Ethics in oncology textbooks. G B WeissxG B WeissSearch for articles by this author , H Y VanderpoolxH Y VanderpoolSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.10.1432 First Page PDF © 1985 by American Society of Clinical OncologyKeywords: Bioethics and Professional EthicsEmpirical Approach... Show All
Abstract 4356: Factors predicting lymph node metastasis in resected lung adenocarcinoma of 2cm or smaller
Authors: Jung-Jyh Hung, Teh-Ying Chou, Yu-Chung Wu, Wen-Hu Hsu
Journal: Cancer Research (2015)

Abstract Objective: The predictive value of the new International Association for the Study of Lung Cancer, American Thoracic Society and European Respiratory Society (IASLC/ATS/ERS) classification of lung adenocarcinoma predicting lymph node metastasis in lung adenocarcinoma has not been well demonstrated. Methods: Histological classification of 246 patients undergoing anatomical resection for lung adenocarcinoma of 2cm or smaller was determined according to the IASLC/ATS/ERS classification with recording of the percentage of each histologic component (lepidic, acinar, papillary, micropapillary, and solid). Their predictive value of lymph node metastasis was investigated. Results: Among the 246 patients, there were 215 (87.4%) patients with N0 status, 13 (5.3%) with N1 status, and 18 (7.3%) with N2 status. Greater tumor size (P &amp;lt; 0.001) and predominant pattern group (micropapillary/solid predominant) (P = 0.001) were significantly associated with higher percentage of N1 or N2 lymph node metastasis. In multivariate analysis, greater tumor size (P &amp;lt; 0.001), and micropapillary/solid predominant pattern (P = 0.029) were significant predictors of N1 or N2 lymph node metastasis in tumors of 2cm or smaller. Micropapillary/solid predominant pattern (P = 0.031) was also a significant predictor of N2 lymph node metastasis in multivariate analysis. Conclusions: The IASLC/ATS/ERS classification has significantly predictive value on lymph node metastasis in lung adenocarcinoma of 2cm or smaller. Micropapillary/solid predominant pattern is a predictor of lymph node metastasis. Note: This abstract was not presented at the meeting. Citation Format: Jung-Jyh Hung, Teh-Ying Chou, Yu-Chung Wu, Wen-Hu Hsu. Factors predicting lymph node metastasis in resected lung adenocarcinoma of 2cm or smaller. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4356. doi:10.1158/1538-7445.AM2015-4356
Syndrome comorbidity in patients with major depression or dysthymia: prevalence and temporal relationships
Authors: W C Sanderson, A T Beck, J Beck
Journal: American Journal of Psychiatry (1990)

The authors administered the Structured Clinical Interview for DSM-III-R to 260 patients with principal diagnoses of depressive disorders. Approximately two-thirds of these patients were given at least one additional concurrent axis I disorder. The most common comorbid diagnoses were anxiety disorders. The depressive disorders preceded the anxiety disorders in most patients. The authors not only point out the scientific and clinical implications of psychiatric comorbidity in view of the patterns of comorbidity found in this and previous studies but also discuss issues in comorbidity research.
Advanced Prostate Cancer Follow-Up with Prostate-Specific Antigen, Prostatic Acid Phosphatase, Osteocalcin and Bone Isoenzyme of Alkaline Phosphatase
Authors: C. Curatolo, G.M. Ludovico, M. Correale, A. Pagliarulo, I. Abbate, E. Cirrillo Marucco, A. Barletta
Journal: European Urology (1992)
CORONARY THROMBOSIS IN MYOCARDIAL INFARCTION
Authors: M GILBERT, J ROTSTEIN, C CUNNINGHAM, I ESTRIN, A DAVIDSON, G PINCUS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
A Symmetric Eczematous Eruption Harboring Thousands of Melanocytic Lesions
Authors: Vladimir Ratushny, Stefan Kraft, Samuel L. Moschella, Lyn M. Duncan, Donald P. Lawrence, Hensin Tsao
Journal: JAMA Dermatology (2016)

<h3>Importance</h3> The abrupt appearance of melanocytic lesions is a unique phenomenon that can occur in the setting of eruptive nevi or epidermotropic melanoma metastases. <h3>Objective</h3> To examine the immunohistochemical and genetic mutative features of a novel case of an eczematous reaction followed by the abrupt appearance of melanocytic lesions. <h3>Design, Setting, and Participant</h3> Case report of a 48-year-old woman with no significant medical history who first presented with an eczematous dermatitis on her torso, extremities, and buttocks and who subsequently developed thousands of pinpoint, histologically atypical melanocytic tumors and invasive melanoma within the areas of inflammation. <h3>Main Outcomes and Measures</h3> Immunohistochemical and mutational analyses of the patient’s melanocytic tumors were conducted. <h3>Results</h3> Mutational analysis of the pigmented lesions did not identify any activating mutations in<i>BRAF, PTEN, NRAS, KRAS, </i>and<i> HRAS</i>. Immunohistochemical analyses of 9 biopsied pigmented lesions all showed normal expression of the tumor suppressors p16 and PTEN and no expression of mutated BRAF V600E protein. <h3>Conclusions and Relevance</h3> To our knowledge, this is a previously unreported eruption comprising 2 distinct components: an eczematous reaction and a wave of melanocytic proliferations within the inflammatory regions. Possible explanations for this patient’s condition, include immune stimulation leading to nevogenesis, benign “nevic” metastases, eruptive nevi, and epidermotropic metastatic melanoma.
Ulcerative Colitis
Authors: Janet M. Torpy, Cassio Lynm, Robert M. Golub
Journal: JAMA (2012)

Sigmoid colonRectum Stomach Esophagus Small intestine I nflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn disease make the bowel (intestine) inflamed, irritated, swollen, and unable to function in a healthy way.Ulcerative colitis affects the large intestine (the colon) and the rectum but does not involve the small intestine (the part of the bowel that connects the stomach to the colon and that is responsible for almost all the body's food digestion and absorption of nutrition).Crohn disease affects both the small intestine and the colon.Ulcerative colitis is found almost equally in men and women and tends to appear in young adults, although it can be diagnosed at any age.Ulcerative colitis occurs in families in approximately 2% to 5% of cases, which is a higher frequency than expected by chance, meaning that it sometimes has an inherited (genetic) pattern.The main symptom of the disease is bloody diarrhea, and a person who has this symptom is usually referred to a gastroenterologist, a doctor who specializes in the management of digestive disorders.
Risk of hypersensitivity pneumonitis and interstitial lung diseases among pigeon breeders
Authors: Christine Cramer, Vivi Schlünssen, Elisabeth Bendstrup, Zara Ann Stokholm, Jesper Medom Vestergaard, Morten Frydenberg, Henrik Albert Kolstad
Journal: European Respiratory Journal (2016)

We studied the risk of hypersensitivity pneumonitis and other interstitial lung diseases (ILDs) among pigeon breeders. This is a retrospective follow-up study from 1980 to 2013 of 6920 pigeon breeders identified in the records of the Danish Racing Pigeon Association. They were compared with 276 800 individually matched referents randomly drawn from the Danish population. Hospital based diagnoses of hypersensitivity pneumonitis and other ILDs were identified in the National Patient Registry 1977–2013. Stratified Cox regression analyses estimated the hazard ratios (HR) of hypersensitivity pneumonitis and other ILDs adjusted for occupation, residence and redeemed prescription of medication with ILDs as a possible side-effect. Subjects were censored at death, emigration or a diagnosis of connective tissue disease. The overall incidence rate of ILD was 77.4 per 100 000 person-years among the pigeon breeders and 50.0 among the referents. This difference corresponded to an adjusted HR of 1.56 (95% CI 1.26–1.94). The adjusted HRs of hypersensitivity pneumonitis and other ILDs for pigeon breeders were 14.36 (95% CI 8.10–25.44) and 1.33 (95% CI 1.05–1.69), respectively. This study shows an increased risk of ILD among pigeon breeders compared with the referent population. Protective measures are recommended even though ILD leading to hospital contact remains rare among pigeon breeders.
Acute Epiglottitis in Children
Authors: G L Baliasinskaia, L N Oksamitnaia, D V Popov
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Vascular image registration techniques: A living review
Authors: Stefan Matl, Richard Brosig, Maximilian Baust, Nassir Navab, Stefanie Demirci
Journal: Medical Image Analysis (2016)

Registration of vascular structures is crucial for preoperative planning, intraoperative navigation, and follow-up assessment. Typical applications include, but are not limited to, Trans-catheter Aortic Valve Implantation and monitoring of tumor vasculature or aneurysm growth. In order to achieve the aforementioned goals, a large number of various registration algorithms has been developed. With this review paper we provide a comprehensive overview over the plethora of existing techniques with a particular focus on the suitable classification criteria such as the involved modalities of the employed optimization methods. However, we wish to go beyond a static literature review which is naturally doomed to be outdated after a certain period of time due to the research progress. We augment this review paper with an extendable and interactive database in order to obtain a living review whose currency goes beyond the one of a printed paper. All papers in this database are labeled with one or multiple tags according to 13 carefully defined categories. The classification of all entries can then be visualized as one or multiple trees which are presented via a web-based interactive app (http://livingreview.in.tum.de) allowing the user to choose a unique perspective for literature review. In addition, the user can search the underlying database for specific tags or publications related to vessel registration. Many applications of this framework are conceivable, including the use for getting a general overview on the topic or the utilization by physicians for deciding about the best-suited algorithm for a specific application.
The treatment of depression with ECT in the presence of brain tumor
Authors: D M Dressler, J Folk
Journal: American Journal of Psychiatry (1975)

Traditionally, the presence of brain tumor has been considered an absolute contraindication to the use of electroconvulsive therapy. In selected cases, however, this procedure may be beneficial and at times even lifesaving. The authors point to the need for an eclectic approach to treatment, given the current state of psychiatric knowledge.
Molecular Prognostic Factors in Acute Myeloid Leukemia (AML) Patients Receiving First Line Therapy with Azacytidine (AZA)
Authors: Judith Desoutter, Julie Gay, Céline Berthon, Lionel Ades, Jean Pierre Marolleau, Sandrine Geffroy, Isabelle Plantier, Marceau Alice, Nathalie Helevaut, Jose Fernandes, Maxime Bemba, Cécile Frimat, Julien Labreuche, Olivier Nibourel, Christophe Roumier, Martin Figeac, Pierre Fenaux, Bruno Quesnel, Aline Renneville, Claude Preudhomme
Journal: Blood (2014)
Morning at Antibes
Authors: M Therese Southgate
Journal: JAMA (2006)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract IA12: Mechanisms of tumorigenesis due to somatic mutations in DICER1 and DROSHA in childhood kidney cancers
Authors: Kenneth S. Chen, Dinesh Rakheja, Yangjian Liu, Abhay A. Shukla, Joshua T. Mendell, James F. Amatruda
Journal: Cancer Research (2016)

Abstract Wilms tumor is the most common pediatric kidney cancer and the fourth most common childhood cancer overall. Wilms tumor is treated with a combination of surgery, chemotherapy, and radiation, and, while most children are cured, patients suffer adverse late effects of therapy and survival remains poor in those with advanced-stage disease. Known driver mutations (in WT1, WTX, and β-catenin) account for only one-third of Wilms tumor cases. To better define the genomic landscape of Wilms tumor, we performed whole-exome sequencing of 44 Wilms tumors to identify somatic mutations. Through this approach, we identified recurrent somatic mutations in MYCN, DROSHA, and DICER1, which were mutually exclusive with known Wilms tumor driver mutations in WT1 and β-catenin. DROSHA and DICER1 somatic hotspot mutations occur at or near critical metal-binding residues in RNase III domains and partially or completely disrupt enzyme activity. Examination of miRNA expression in tumors, in vitro processing assays, and genomic editing in human cells demonstrate that DICER1 and DROSHA mutations influence miRNA processing through distinct mechanisms. While DICER1 RNase IIIB mutations preferentially impair processing of miRNAs that derive from the 5′ arm of pre-miRNA hairpins, DROSHA RNase IIIB mutations globally inhibit miRNA biogenesis through a dominant-negative mechanism. Despite their distinct mechanisms of action, DROSHA and DICER1 mutations result in decreased expression of several common tumor-suppressing miRNAs, including multiple members of the let-7 and miR-15/16 families. We also identified a patient carrying a germline DICER1 loss-of-function allele who subsequently developed multiple malignancies with distinct DICER1 RNase IIIB somatic hotspot mutations, suggesting that DICER1 can act as both a tumor-suppressor and an oncogene depending on the nature of the mutation. These results provide new insights into the mechanisms through which mutations in miRNA biogenesis components reprogram miRNA expression in human cancer and suggest that mutations causing impairment of miRNA processing define a distinct subclass of Wilms tumors. Citation Format: Kenneth S. Chen, Dinesh Rakheja, Yangjian Liu, Abhay A. Shukla, Joshua T. Mendell, James F. Amatruda. Mechanisms of tumorigenesis due to somatic mutations in DICER1 and DROSHA in childhood kidney cancers. [abstract]. In: Proceedings of the AACR Special Conference on Noncoding RNAs and Cancer: Mechanisms to Medicines ; 2015 Dec 4-7; Boston, MA. Philadelphia (PA): AACR; Cancer Res 2016;76(6 Suppl):Abstract nr IA12.