tbuckley/cabot-search huggingface dataset:
Lymphatic vessels regulate immune microenvironments in human and murine melanoma
Authors: Amanda W. Lund, Marek Wagner, Manuel Fankhauser, Eli S. Steinskog, Maria A. Broggi, Stefani Spranger, Thomas F. Gajewski, Kari Alitalo, Hans P. Eikesdal, Helge Wiig, Melody A. Swartz
Journal: Journal of Clinical Investigation (2016)

Lymphatic remodeling in tumor microenvironments correlates with progression and metastasis, and local lymphatic vessels play complex and poorly understood roles in tumor immunity. Tumor lymphangiogenesis is associated with increased immune suppression, yet lymphatic vessels are required for fluid drainage and immune cell trafficking to lymph nodes, where adaptive immune responses are mounted. Here, we examined the contribution of lymphatic drainage to tumor inflammation and immunity using a mouse model that lacks dermal lymphatic vessels (K14-VEGFR3-Ig mice). Melanomas implanted in these mice grew robustly, but exhibited drastically reduced cytokine expression and leukocyte infiltration compared with those implanted in control animals. In the absence of local immune suppression, transferred cytotoxic T cells more effectively controlled tumors in K14-VEGFR3-Ig mice than in control mice. Furthermore, gene expression analysis of human melanoma samples revealed that patient immune parameters are markedly stratified by levels of lymphatic markers. This work suggests that the establishment of tumor-associated inflammation and immunity critically depends on lymphatic vessel remodeling and drainage. Moreover, these results have implications for immunotherapies, the efficacies of which are regulated by the tumor immune microenvironment.
Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis
Authors: Lorena Alba-Castellón, Rubén Olivera-Salguero, Aida Mestre-Farrera, Raúl Peña, Mercedes Herrera, Félix Bonilla, J. Ignacio Casal, Josep Baulida, Cristina Peña, Antonio García de Herreros
Journal: Cancer Research (2016)

Abstract Snail1 transcriptional factor is essential for triggering epithelial-to-mesenchymal transition (EMT) and inducing tumor cell invasion. We report here an EMT-independent action of Snail1 on tumor invasion, as it is required for the activation of cancer-associated fibroblasts (CAF). Snail1 expression in fibroblasts requires signals derived from tumor cells, such as TGFβ; reciprocally, in fibroblasts, Snail1 organizes a complex program that stimulates invasion of epithelial cells independent of the expression of Snail1 in these cells. Epithelial cell invasion is stimulated by the secretion by fibroblast of diffusible signaling molecules, such as prostaglandin E2. The capability of human or murine CAFs to promote tumor invasion is dependent on Snail1 expression. Inducible Snail1 depletion in mice decreases the invasion of breast tumors; moreover, epithelial tumor cells coxenografted with Snail1-depleted fibroblasts originated tumors with lower invasion than those transplanted with control fibroblasts. Therefore, these results demonstrate that the role of Snail1 in tumor invasion is not limited to EMT, but it is also dependent on its activity in stromal fibroblasts, where it orchestrates the cross-talk with epithelial tumor cells. Cancer Res; 76(21); 6205–17. ©2016 AACR.
Population Based Analysis of Outcomes of Primary Central Nervous System Lymphoma (PCNSL) Suggests a Treatment Strategy Including Intensive Chemotherapy with Autologous Stem Cell Transplantation Provides a Survival Advantage for Patients &lt;65 Years of Age
Authors: Joanna Graczyk, Sunita Ghosh, Neil Chua, Douglas A. Stewart, Carolyn J. Owen
Journal: Blood (2014)
Association Between Serum Calcium Level and Extent of Bleeding in Patients With Intracerebral Hemorrhage
Authors: Andrea Morotti, Andreas Charidimou, Chia-Ling Phuah, Michael J. Jessel, Kristin Schwab, Alison M. Ayres, Javier M. Romero, Anand Viswanathan, M. Edip Gurol, Steven M. Greenberg, Christopher D. Anderson, Jonathan Rosand, Joshua N. Goldstein
Journal: JAMA Neurology (2016)

<h3>Importance</h3> Calcium is a key cofactor of the coagulation cascade and may play a role in the pathophysiology of intracerebral hemorrhage (ICH). <h3>Objective</h3> To investigate whether a low serum calcium level is associated with an increase in the extent of bleeding in patients with ICH as measured by baseline hematoma volume and risk of hematoma expansion. <h3>Design, Setting, and Participants</h3> Prospective cohort study of 2103 consecutive patients with primary ICH ascertained during the period between 1994 and 2015 at an academic medical center. The statistical analysis was performed in January 2016. <h3>Main Outcomes and Measures</h3> Total calcium level was measured on admission, and hypocalcemia was defined as a serum calcium level of less than 8.4 mg/dL. Baseline and follow-up hematoma volumes, detected by noncontrast computed tomography, were measured using a computer-assisted semiautomatic analysis. Hematoma expansion was defined as an increase of more than 30% or 6 mL from baseline ICH volume. Associations between serum calcium level and baseline hematoma volume and between serum calcium level and ICH expansion were investigated in multivariable linear and logistic regression models, respectively. <h3>Results</h3> A total of 2123 patients with primary ICH were screened, and 2103 patients met the inclusion criteria (mean [SD] age, 72.7 [12.5] years; 54.3% male patients), of whom 229 (10.9%) had hypocalcemia on admission. Hypocalcemic patients had a higher median baseline hematoma volume than did normocalcemic patients (37 mL [IQR, 15-72 mL] vs 16 mL [IQR, 6-44 mL];<i>P</i> &lt; .001). Low calcium levels were independently associated with higher baseline ICH volume (β = −0.13, SE = .03,<i>P</i> &lt; .001). A total of 1393 patients underwent follow-up noncontrast computed tomography and were included in the ICH expansion analysis. In this subgroup, a higher serum calcium level was associated with reduced risk of ICH expansion (odds ratio, 0.55 [95% CI, 0.35-0.86];<i>P</i> = .01), after adjusting for other confounders. <h3>Conclusions and Relevance</h3> Hypocalcemia correlates with the extent of bleeding in patients with ICH. A low calcium level may be associated with a subtle coagulopathy predisposing to increased bleeding and might therefore be a promising therapeutic target for acute ICH treatment trials.
Possible determinants of VSL#3 probiotic failure in preventing gastrointestinal adverse events associated with dacomitinib in patients with advanced non-small-cell lung cancer enrolled in ARCHER-1042 trial
Authors: G. Ceccarelli, I. Schietroma, G. Corano Scheri, G. d'Ettorre, V. Vullo
Journal: Annals of Oncology (2016)
P0874 : Outcomes of 12-week therapy with simeprevir + sofosbuvir +/− ribavirin (SMV+SOF±RBV): A meta-analysis of 7 studies and 715 HCV genotype 1 (HCV-1) patients
Authors: B.E. Yee, N.H. Nguyen, G.A. Lutchman, J.K. Lim, M.H. Nguyen
Journal: Journal of Hepatology (2015)
Pediatric Emergency Medicine
Authors: Derek S. Wheeler
Journal: JAMA (2010)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract 120: Reduced Long Term Memory in Morris Water Maze in Rats Resuscitated From Ventricular Fibrillation Cardiac Arrest
Authors: Wolfgang Weihs, Ingrid A Magnet, Florian Ettl, Alexandra Warenits, Ursula Teubenbacher, Andreas Hilpold, Johann Sipoetz, Akos Tiboldi, Fritz Sterz, Michael Holzer, Andreas Janata
Journal: Circulation (2013)

Background: Rodent models of cardiac arrest (CA) help to investigate pathophysiologic mechanisms of cerebral ischemia and reperfusion. Sensitive neurologic tests would enhance the ability of such models to evaluate possible beneficial effects of protective therapies. The Morris Water Maze (MWM) is a procedure to test spatial learning and memory. The aim of this study was to investigate behavioral testing with the Morris Water Maze in rats resuscitated from ventricular fibrillation (VF) CA.

Methods: Sprague-Dawley rats (379±13g, male, anesthetized) were put into VF CA. After 8 min of CA the animals received mechanical chest compressions for 2 min and epinephrine 20 μg/kg. The animals were defibrillated thereafter every 2 min to achieve return of spontaneous circulation. Ten animals surviving with favorable neurologic recovery were compared to 10 naive rats. MWM testing was performed in each animal 3 times on 4 consecutive days for maximal 120 s with a hidden platform and on day 5 and day 12 with the platform removed.

Results: The latency time to find the hidden platform (reflecting spatial learning) decreased in the CPR group and the control group from 107±31 s and 75±42 s to 10±5 s and 17±14 s between day 1 and day 4 (p=0.11). After removal of the platform, the time within the target sector on day 5 (reflecting short term memory) in 60 s was 24±6 s and 25±8 s (p=0.87).Time within the target sector on day 12 (reflecting long term memory) was significantly reduced in the CPR group vs. naive rats with 15±3 s and 18±2 s (p=0.03)

Conclusions: Spatial learning and short-term memory in clinical neurologically intact animals resuscitated from an 8 min VF CA was comparable to normal healthy controls. Long term memory after a 7-day period without training was reduced. Memory retention rather than short term may prove valuable in this global ischemia model as behavioral testing strategy.
Hypoxia-inducible factors: key regulators of myeloid cells during inflammation
Authors: Nan Lin, M. Celeste Simon
Journal: Journal of Clinical Investigation (2016)

Hypoxia is a prominent characteristic of many acute or chronic inflammatory diseases, and exerts significant influence on their progression. Macrophages and neutrophils are major cellular components of innate immunity and contribute not only to O2 deprivation at the site of inflammation, but also alter many of their functions in response to hypoxia to either facilitate or suppress inflammation. Hypoxia stabilizes HIF-αs in macrophages and neutrophils, and these O2-sensitive transcription factors are key regulators of inflammatory responses in myeloid cells. In this review, we will summarize our current understanding of the role of HIF-αs in shaping macrophage and neutrophil functions in the pathogenesis and progression of multiple inflammatory diseases.
G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol
Authors: Rong Qi, Yan-zhi Li, Cong Chen, Yi-ni Cao, Mao-mao Yu, Lu Xu, Bing He, Xu Jie, Wen-wen Shen, Yu-nan Wang, Mallory A. van Dongen, Guo-qing Liu, Mark M. Banaszak Holl, Qiang Zhang, Xue Ke
Journal: Journal of Controlled Release (2015)
The day of reckoning: Does human ultrasociality continue?
Authors: Carolyn A Ristau
Journal: Behavioral and Brain Sciences (2016)

To counter human ultrasociality, alternative communities can arise (ongoing), and, unlike insects, lower echelons can unite and rebel. Examples include movements such as: "Black Lives Matter," "Fight for $15," "Occupy," and the "Village Movement." To strengthen ultrasociality, a surplus bottom echelon can be reduced: for example, by means such as imprisoning Blacks, deporting immigrants, wars, and the Holocaust. Alternatively, a new structure could be created, for example, ISIL (even more ultrasocial?).
Sedentary Behavior and Cardiovascular Morbidity and Mortality: A Science Advisory From the American Heart Association
Authors: Deborah Rohm Young, Marie-France Hivert, Sofiya Alhassan, Sarah M. Camhi, Jane F. Ferguson, Peter T. Katzmarzyk, Cora E. Lewis, Neville Owen, Cynthia K. Perry, Juned Siddique, Celina M. Yong
Journal: Circulation (2016)

Epidemiological evidence is accumulating that indicates greater time spent in sedentary behavior is associated with all-cause and cardiovascular morbidity and mortality in adults such that some countries have disseminated broad guidelines that recommend minimizing sedentary behaviors. Research examining the possible deleterious consequences of excess sedentary behavior is rapidly evolving, with the epidemiology-based literature ahead of potential biological mechanisms that might explain the observed associations. This American Heart Association science advisory reviews the current evidence on sedentary behavior in terms of assessment methods, population prevalence, determinants, associations with cardiovascular disease incidence and mortality, potential underlying mechanisms, and interventions. Recommendations for future research on this emerging cardiovascular health topic are included. Further evidence is required to better inform public health interventions and future quantitative guidelines on sedentary behavior and cardiovascular health outcomes.
Tooth loss as a predictor of shortened longevity: exploring the hypothesis
Authors: Paula K. Friedman, Ira B. Lamster
Journal: Periodontology 2000 (2016)

Abstract Many factors contribute to human tooth loss, including oral hygiene practices, trauma, smoking, health status, socio‐economic status and individual preferences. Loss of teeth impairs quality‐of‐life measures, including the eating of most foods that require full masticatory function. A recent study of centenarians found that at age 65–74 years, those who lived to be 100 had a lower rate of edentulism than did younger members of their birth cohort at ages 65–74 years. Oral health was consistent with compression of morbidity toward the end of life. This article explores the hypothesis that factors associated with oral disease and noncommunicable diseases may increase the risk of tooth loss and lead to diminished longevity as a result of multifactorial interactions. It specifically addresses two critical questions. The first is: ‘Can we conclude that the number of teeth in aging humans can affect longevity and life expectancy?’ The answer is yes. The second is: ‘Is tooth loss a predictor of shortened longevity?’ Again, the answer is yes. Edentulism and partial edentulism are discussed as a disability, and how the philosophy/belief systems of dental providers and patients toward retaining teeth influences the outcome of tooth loss is also examined. Osteoporosis and cognitive impairment provide examples of modifying risk factors.
International Olympic Committee Diploma in Sports Physical Therapies: a new online programme for therapists working with athletes and sporting teams (continuing professional development series)
Authors: Adam G Culvenor
Journal: British Journal of Sports Medicine (2016)

International Olympic Committee (IOC).

IOC Diploma in Sports Physical Therapies (online-learning).

The success of individual athletes and sporting teams relies on players staying healthy, remaining injury free and recovering quickly from medical issues. One only has to look as far as last season's English Premier League, where Leicester City's unlikely success coincided with the league's lowest rate of injuries and least players used,1 to appreciate the importance of keeping athletes fit to compete. In recognition of the key role physical therapists (physiotherapists) and other similar health professionals (eg, athletic trainers) play in the successful prevention and management of sporting injuries,2 the Medical Commission of the IOC launched a new diploma in sports physical therapies in 2015.

The programme provides an avenue to specialise in the area of sports physical therapies to ultimately optimise medical care for elite and recreational athletes.3 While its content is based on postgraduate sports physiotherapy courses offered by leading universities, …
Aerosolized avian influenza A (H5N6) virus isolated from a live poultry market, China
Authors: Yanheng Wu, Wuyang Shi, Jinsi Lin, Man Wang, Xueqin Chen, Kangkang Liu, Ying Xie, Le Luo, Benjamin D Anderson, John A Lednicky, Gregory C Gray, Jiahai Lu, Tao Wang
Journal: Journal of Infection (2016)
Abstract 994: Cardioprotection Against Myocardial Infarction by Ischemic Pre- and Post-Conditioning are Both Completely Abrogated by Acute Hyperglycemia
Authors: Zequan Yang, Yaqin Xu, Irving L Kron, Brent A French
Journal: Circulation (2007)

Introduction: Acute hyperglycemia (HG) is associated with larger infarct size, impaired cardiac function and increased mortality, independent of diabetes. We hypothesized that the cardioprotective effects of both ischemic pre- and post-conditioning (pre-C &amp; post-C) would be impacted by acute HG. Methods: A total of 37 C57BL/6 mice were assigned to 6 groups. All mice underwent 40 min of LAD occlusion followed by 60 min of reperfusion. Acute HG (~400 mg/dl) was induced in 3 groups with an IP injection of dextrose (2g/kg body weight) given 40 min prior to the start of index ischemia. The ischemic pre-C protocol (2 groups) was 2 cycles of 5 min ischemia and 5 min reperfusion prior to index ischemia. The post-C protocol (2 groups) was 3 cycles of 5 sec reperfusion and 5 sec ischemia following index ischemia. Results: Risk region (RR, % of LV) as determined by Phthalo blue staining was similar among study groups (Fig , p = NS). In euglycemic control mice, infarct size (by TTC staining) without cardioprotection was 51.6 ± 2.0 % of RR (Fig ). Early pre-C reduced infarct size to 25.5 ± 3.7 (a 50% reduction, p &lt; 0.05 vs control) while post-C reduced it to 37.9 ± 0.5 (a 27% reduction, p &lt; 0.05 vs control). In HG mice, infarct size was significantly exacerbated to 63.1 ± 2.9 (a 22% increase, p &lt; 0.05 vs euglycemic controls). Cardioprotection by pre-C was completely abrogated in HG mice (55.9 ± 3.6 of RR, p = NS vs HG controls). Similarly, post-C was completely ineffective in protecting HG mice against infarction (59.4 ± 2.5, p = NS vs HG controls). Conclusion: Acute hyperglycemia in non-diabetic mice completely abolishes the cardioprotective effects of both ischemic pre-C and post-C against myocardial infarction.
Direct-to-Consumer Drug Advertising in Oncology Is Not Beneficial to Patients or Public Health
Authors: Lowell E. Schnipper, Gregory A. Abel
Journal: JAMA Oncology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Neurally adjusted ventilatory assist as an alternative to pressure support ventilation in adults: a French multicentre randomized trial
Authors: A. Demoule, M. Clavel, C. Rolland-Debord, S. Perbet, N. Terzi, A. Kouatchet, F. Wallet, H. Roze, F. Vargas, C. Guerin, J. Dellamonica, S. Jaber, L. Brochard, T. Similowski
Journal: Intensive Care Medicine (2016)
Normal Response to Aspirin in Healthy Individuals: Cross-Comparison of Light Transmission Aggregometry, VerifyNow™ System, Platelet Count Drop, Thrombelastography (TEG®) and Urinary 11-dehydrothromboxane B2.
Authors: Normand Blais, Marie Lordkipanidze, Chantal Pharand, Ying Sia, Yahye Merhi, Jean G. Diodati
Journal: Blood (2007)
Adult female acne and associated risk factors: Results of a multicenter case-control study in Italy
Authors: Anna Di Landro, Simone Cazzaniga, Francesco Cusano, Angela Bonci, Cardinali Carla, Maria Letizia Musumeci, Annalisa Patrizi, Vincenzo Bettoli, Enrico Pezzarossa, Marzia Caproni, Anna Belloni Fortina, Elena Campione, Vito Ingordo, Luigi Naldi
Journal: Journal of the American Academy of Dermatology (2016)
Коллоидный субцитрат висмута в лечении хеликобактерной инфекции
Authors: A.E. Dorofeiev, M.M. Rudenko, A.V. Sibiliov
Journal: GASTROENTEROLOGY (2016)

Статья посвящена проблеме лечения хеликобактерной инфекции. Рассматриваются схемы терапии, рекомендованные к применению в настоящее время и соответствущие последним данным доказательной медицины. Согласно результатам исследования, проведенного в 2015 году в Украине, четырехкомпонентная терапия первой линии с включением субцитрата висмута показала эффективность более 90 % в восточном и центральном регионах нашей страны, также было продемонстрировано превосходство висмутсодержащей схемы над стандартной (89 и 55 % случаев успешной эрадикации соответственно). В данной работе представлены результаты исследования эффективности антихеликобактерной терапии первой линии, включающей ингибитор протонной помпы, кларитромицин, амоксициллин с добавлением коллоидного субцитрата висмута (препарат Де-Нол) у больных с высоким риском развития устойчивости к кларитромицину. В группе больных высокого риска резистентности к кларитромицину добавление к стандартной 3-компонентной терапии коллоидного субцитрата висмута привело к увеличению эффективности эрадикации на 22,1 %, что свидетельствует о целесообразности включения коллоидного субцитрата висмута (Де-Нол) в схему лечения данной категории пациентов.