AB0454 The Outcome of SLE Residents of Kyrgyzstan According To The Prospective Study
Authors: G. Koilubaeva, E. Aseeva, S. Soloviev, E. Nasonov, T. Reshetnyak, A. Djumagulova, V. Eralieva, E. Karimova
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a devastating disease affecting different organs, ultimately leading to organ failure and death. To date, there are no data regarding the real-life picture of SLE in Kyrgyzstan. <h3>Objectives</h3> To study the outcomes of SLE according prospective study among residents of Kyrgyzstan. <h3>Methods</h3> An 2-year prospective analysis of patients with SLE with a specially developed research base (BLIPS 8, ADS-Limathon).60 patients with definite diagnosis of SLE (ACR, 1997; SLICC, 2012), were treated in the department of rheumatology of NCCIM and observed from 2012 to 2015. They were evaluated by sex, age, disease duration, activity of SLE according the SLEDAI-2K, irreversible organ damage by SDI, therapy, with monitoring of all parameters every six months for 2 years. From the data of the immunological studies immune linear (immunoblot) "ANA-LIA-Max 17" were analyzed with a purpose of detecting the antibodies of double-stranded DNA, Sm D1 antigen and antibodies of double-stranded DNA-linked immunosorbent analyisis (ELISA), C3-C4 components complement, indirect immunofluorescence of the antinuclear antibody cells of line Hep-2. <h3>Results</h3> The vast majority were women (86.7%), with average age 30 years old, with disease duration of about 1.0 years. Periods to verify the diagnosis ranged from 1 month to 9 years. The clinical course was dominated by patients with acute version (47%) and high activity (57%). In the debut of the disease most common clinical symptoms were cutaneous and articular syndrome (84.2% and 72.3%, respectively), the defeat of the serous membranes (88%) and kidney (68%). The development of irreversible organ damage recorded in half the patients (46%), on average of 6 months from the onset of the disease, preferably with low (36.7%) and the average SDI (21.7%). Among the irreversible organ damage leading place is occupied by respiratory failure (53.5%) of them with pulmonary fibrosis (21.4%) and pulmonary hypertension (25%). Second place takes kidney disease (50%) with severe forms of nephritis (nephrotic syndrome and chronic renal failure). Irreversible changes in the central nervous system were observed in 21% of patients. Over the whole period there were 14 fatal cases (19.4%). They were mostly women (72%) with average age 37.9 years, with disease duration around 4 years. The main causes of death were active SLE and its complications: kidney disease (29%), central nervous system (CNS)-21.4% and combined CNS and lung (21.4%). During the two-year observation, despite the significant decrease in disease activity (p&lt;0,001), the progression of SDI (p&lt;0,0001), deterioration of whom are independent from both the activity and the variant of the disease (r =0.18, p=0.2; r =0.03, p=0.8 respectively) is noted. However, the degree of organ damage depended on the duration of illness (r=0.27, p&lt;0,03) and the age of patients (r =0.29, p=0.02). <h3>Conclusions</h3> Irreversible organ damage of the respiratory organs (pulmonary fibrosis, pulmonary hypertension), renal, and CNS were the main predictors of adverse outcome of SLE among the residents of Kyrgyzstan. <h3>Disclosure of Interest</h3> None declared