tbuckley/cabot-search huggingface dataset:
The WHO collaborative study on strategies for extending mental health care, IV: A training approach to enhancing the availability of mental health manpower in a developing country
Authors: R S Murthy, N N Wig
Journal: American Journal of Psychiatry (1983)

Part of the WHO collaborative study is the training of general health workers to provide mental health services. The authors describe the training program used in Raipur Rani, chandigarh, India, to train medical ancillaries (called peripheral health workers). Training methods used were based on evaluation of 1) Workers' existing knowledge of and attitudes toward mental health problems, 2) existing training materials, 3) the need for new training materials, and 4) the support and supervision workers needed to carry out their duties. Use of the workers has greatly increased the availability of mental health services.
A Comparison of Continuous Infusion of Alteplase with Double-Bolus Administration for Acute Myocardial Infarction
Journal: New England Journal of Medicine (1997)

Accelerated infusion of alteplase (tissue plasminogen activator) over a period of 90 minutes induces more rapid lysis of coronary-artery thrombi than a 3-hour infusion. With two bolus doses of alteplase, further shortening the duration of administration, complete reperfusion was achieved in more than 85 percent of the patients in initial angiographic studies. We tested the hypothesis that double-bolus alteplase is at least as effective as accelerated infusion.
Treatment outcome monitoring of pulmonary tuberculosis cases notified in France in 2009
Authors: D Antoine, D Che
Journal: Eurosurveillance (2013)

The proportion of patients considered to be cured is a key indicator to assess national tuberculosis (TB) control. In France, TB treatment outcome monitoring was implemented in 2007. This article presents national results on treatment outcome among patients with pulmonary TB reported in France in 2009 and explores determinants of potentially unfavourable outcome. Information on treatment outcome was reported for 63% of eligible pulmonary cases of whom 70% had a successful outcome. In a multivariate analysis, potentially unfavourable outcome (17%), compared to treatment success, was significantly associated with being male, born abroad and having lived in France for less than 10 years, being in congregate settings when treatment was initiated, or having a previous history of anti-TB treatment. Enhanced awareness of treatment outcome monitoring is essential to improve the coverage and the quality of information. Earlier diagnosis and improved management of the disease in the elderly may reduce death due to TB. The high proportion of potentially unfavourable outcomes should be further investigated as they may require additional vigilance and/or actions in term of efforts of TB control in some population groups.
Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis
Authors: Juan M. Fernández-Alvira, Valentin Fuster, Beatriz Dorado, Nora Soberón, Ignacio Flores, Mercedes Gallardo, Stuart Pocock, María A. Blasco, Vicente Andrés
Journal: Journal of the American College of Cardiology (2016)

Leucocyte telomere length (LTL) shortening is associated with cardiovascular ischemic events and mortality in humans, but data on its association with subclinical atherosclerosis are scarce. Whether the incidence and severity of subclinical atherosclerosis are associated with the abundance of critically short telomeres, a major trigger of cellular senescence, remains unknown. The authors conducted a cross-sectional exploration of the association between subclinical atherosclerosis burden and both average LTL and the abundance of short telomeres (%LTL<3 kb). Telomere length was assessed by high-throughput quantitative fluorescence in situ hybridization in circulating leukocytes from 1,459 volunteers without established cardiovascular disease (58% men, 40 to 54 years of age) from the PESA (Progression of Early Subclinical Atherosclerosis) study. Subclinical atherosclerosis was evaluated by coronary artery calcium scan and 2-dimensional/3-dimensional ultrasound in different aortic territories. Statistical significance of differences among multiple covariates was assessed with linear regression models. Independent associations of telomere parameters with plaque presence were evaluated using general linear models. In men and women, age was inversely associated with LTL (Pearson's r = −0.127, p < 0.001) and directly with %LTL<3 kb (Pearson's r = 0.085; p = 0.001). Short LTL reached statistical significance as a determinant of total and femoral plaque in men, but not in women. However, this association was not sustained after adjustment for age or additional adjustment for cardiovascular risk factors. No significant independent association was found between %LTL<3 kb and plaque burden. Serum-oxidized low-density lipoprotein levels were directly associated with %LTL<3 kb in men (p = 0.008) and women (p < 0.001). In a cross-sectional study of a middle-aged population, average LTL and short telomere load are not significant independent determinants of subclinical atherosclerosis. Longitudinal follow-up of PESA participants will assess long-term associations between telomere length and progression of subclinical atherosclerosis.
Antisense Inhibition of c-fes Proto-oncogene Blocks PMA-Induced Macrophage Differentiation in HL60 and in FDC-P1/MAC-11 Cells
Authors: Rossella Manfredini, Raffaella Balestri, Enrico Tagliafico, Francesca Trevisan, Michela Pizzanelli, Alexis Grande, Daniela Barbieri, Patrizia Zucchini, Gennaro Citro, Claudio Franceschi, Sergio Ferrari
Journal: Blood (1997)
Abstract IA02: Genomic classification of ovarian cancer.
Authors: David D. L. Bowtell
Journal: Clinical Cancer Research (2016)

Abstract Human cancers have been classified for hundreds of years primarily by their anatomical location, and more recently by morphological criteria and the extent of local and distant spread. As cancer is quintessentially a genetic disease, genomics has allowed a reclassification of human cancers, including ovarian cancer, based on gene expression, epigenetic modification, mutational and copy number profiles. The presentation will describe how genomic analyses have helped highlight important molecular distinctions between and within histological subtypes of ovarian cancer, improved the diagnosis of rare subtypes, identified molecular subtypes with different biological properties and clinical outcomes, elucidated driver mutations in primary and recurrent disease, and suggested new approaches to the clinical management of ovarian cancer. Citation Format: David D. L. Bowtell. Genomic classification of ovarian cancer. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr IA02.
Identification of tumor-specific T cell receptors from primary tumor-infiltrating lymphocytes
Authors: Hiroyuki Kishi, Hiroshi Hamana, Kiyomi Shitaoka, Atsushi Muraguchi
Journal: Journal for ImmunoTherapy of Cancer (2015)

Meeting abstracts Antigen-specific adaptive T cell therapy or T cell receptor (TCR) gene therapy is promising as a next generation tumor therapy. For the therapy, the production of tumor-specific T cells or their TCRs is prerequisite. Exploration of tumor-associated antigens, antigen-specific T
Keyhole Limpet Hemocyanine Can Enhance the Natural Killer Activity of Patients with Transitional Cell Carcinoma of the Bladder
Authors: L M Moltó, J Carballido, C Jurincic, P Lapeña, L Manzano, I Salmerón, K F Klippel, M Alvarez-Mon
Journal: European Urology (1991)
Sunitinib Pretreatment Does not Impair Tumor Infiltrating Lymphocyte (Til) Expansion but Reduces Intratumoral Content of Myeloid-Derived Suppressor Cells (Mdsc) in Metastatic Renal Cell Carcinoma
Authors: C. Blank, A. Guislain, J. Gadiot, A. Kaiser, K. Jordanova, A. Broeks, H. van Boven, T. De Gruijl, J.B.A.G. Haanen, A. Bex
Journal: Annals of Oncology (2014)
Q&amp;A: Suzanne Topalian on Immune Therapies
Authors: Suzanne Topalian
Journal: Cancer Discovery (2013)

Suzanne Topalian, MD, professor of surgery and oncology and director of the melanoma program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins in Baltimore, MD, discusses progress with drugs that inhibit immune-checkpoint receptors and ligands, including PD-1 and PD-L1 inhibitors.
Abstract IA21: An integrated genome-wide systems genetics screen for breast cancer metastasis susceptibility genes
Authors: Kent W. Hunter, Ling Bai, Howard H. Yang, Ying Hu, Anjali Shukla, Ngoc-Han Ha, Anthony Doran, Farhoud Faraji, Natalie Goldberger, Maxwell P. Lee, Thomas Keane
Journal: Cancer Research (2016)

Abstract Metastasis remains the primary cause of patient morbidity and mortality in solid tumors and is due to the action of a large number of tumor-autonomous and non-autonomous factors. Hundreds or thousands of genes are thought to be associated with metastasis however how many of these genes contribute etiologically to tumor progression is not currently known. Identification of the genes contributing mechanistically to the metastatic processes will not only deepen our understanding of how metastases occur, but also provide novel targets for either preventing their formation or combatting their life-threatening effects. Previously our laboratory demonstrated that inbred mice of distinct phylogenetic lineages possess distinct propensity for metastatic disease, indicating that inherited susceptibility for metastasis exists and that polymorphisms can both mark and functionally effect genes within the metastatic cascade. Here we report the results of a genome-wide integrated strategy to identify novel metastasis susceptibility candidate genes and molecular pathways which implicates a number of transcriptional regulators and suggests cell-mediated immunity is an important determinant. The strategy described integrates meiotic genetic screens with epigenetic control of gene expression and three dimensional chromatin structure analyses to identify genes, molecular and cellular pathways likely to be important in metastatic disease. Moreover, the analysis identified novel or FDA-approved drugs as potentially useful for anti-metastatic therapy. Further explorations implementing this strategy may therefore provide a variety of information for clinical applications in the control and treatment of advanced neoplastic disease. Citation Format: Kent W. Hunter, Ling Bai, Howard H. Yang, Ying Hu, Anjali Shukla, Ngoc-Han Ha, Anthony Doran, Farhoud Faraji, Natalie Goldberger, Maxwell P. Lee, Thomas Keane. An integrated genome-wide systems genetics screen for breast cancer metastasis susceptibility genes. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA21.
Treatment of divorcing fathers: social and psychotherapeutic considerations
Authors: J W Jacobs
Journal: American Journal of Psychiatry (1983)

The author summarizes the psychotherapeutic issues most frequently encountered in his crisis treatment of 16 divorcing fathers for whom divorce was fundamentally a child-centered crisis. Fear and guilt over separation from children and wife, outrage and disappointment with the legal system, anxiety about the social and sexual readjustment to single life, and the need to develop strategies for continued child contact were most prevalent. The author's suggestions for the management of these issues include the therapist's familiarization with divorce as it affects and is influenced by intrapsychic, interpersonal, familial, and legal systems.
A phase II study of gemcitabine plus carboplatin as adjuvant chemotherapy in patients with resected NSCLC
Authors: Reiko Yoshino, Yoshio Tomizawa, Kousuke Takei, Mai Tomizawa, Akihiro Yoshii, Osamu Kawashima, Satoru Watanabe, Takeshi Hisada, Ryusei Saitou, Masanobu Yamada
Journal: Annals of Oncology (2015)
Insulin
Authors: Sharon Parmet, Cassio Lynm, Richard M. Glass
Journal: JAMA (2007)

Insulin Insulin is produced by special cells in the pancreas, a large organ located behind the stomach.Insulin helps the body use and store glucose (sugar), which is produced during the digestion of food.Insulin is secreted into the blood at each meal and allows the body to use glucose as energy to fuel basic daily functions like moving and breathing.The January 10, 2007, issue of JAMA includes an article about treatment of diabetes.This Patient Page is based on one previously published in the May 7, 2003, issue of JAMA.
Abstract A03: Krüppel-like Transcription Factor-10 (KLF10) suppresses the TGFβ-induced epithelial-to-mesenchymal transition
Authors: Vivek Kumar Mishra, Vijayalakshmi Kari, Malayannan Subramaniam, Simon J. Baumgart, Sankari Nagarajan, Florian Wegwitz, Thomas C. Spelsberg, John R. Hawse, Steven A. Johnsen
Journal: Cancer Research (2016)

Abstract The Transforming Growth Factor-β (TGFβ)/SMAD signaling pathway can function as either a tumor suppressor or metastasis promoter during tumor progression. In normal epithelial cells and early stages of epithelial tumorigenesis TGFβ functions as a tumor suppressor to decrease cell proliferation or induce apoptosis. However, during malignant progression tumor cells no longer respond to the anti-proliferative effects of TGFβ, but instead undergo an epithelial-to-mesenchymal transition (EMT) whereby cells acquire a migratory and invasive phenotype which promotes tumor metastasis. Resolution of the dichotomy in TGFβ function and a further understanding of its tumor suppressor and metastasis promoting functions may uncover new strategies for the treatment of epithelial cancers. In previous studies we demonstrated an important role of the TGFβ-Inducible Early Gene-1 (TIEG1)/Krüppel-like Factor-10 (KLF10) as a central regulator of TGFβ/SMAD signaling and the anti-proliferative functions of TGFβ. In this study we examined the role of KLF10 in controlling the TGFβ-induced EMT in human lung adenocarcinoma cells. We show that depletion of KLF10 results in a more pronounced induction of EMT in human A549 lung adenocarcinoma cells as assessed by quantitative real-time PCR, changes in cellular morphology and immunofluorescence microscopy, and transcriptome-wide (RNA-seq) analyses. Moreover, chromatin immunoprecipitation (ChIP) and chromatin immunoprecipitation-sequencing (ChIP-seq) analysis shows that KLF10 directly binds to GC-rich sequences in the promoter region of the EMT-promoting transcription factor SLUG/SNAI2 to repress its transcription. Consistent with these findings, an analysis of KLF10 and SNAI2 expression in lung cancer revealed that while KLF10 levels are decreased in lung cancer vs. normal samples, SNAI2 levels are increased. Additional ChIP studies showed that KLF10 recruits HDAC1 to the SNAI2 promoter and is required for the removal of activating histone acetylation marks. These findings reveal a previously unknown function of KLF10 in suppressing TGFβ-induced EMT and represent a significant advancement in the understanding the molecular dichotomy of TGFβ function during tumor progression. Citation Format: Vivek Kumar Mishra, Vijayalakshmi Kari, Malayannan Subramaniam, Simon J. Baumgart, Sankari Nagarajan, Florian Wegwitz, Thomas C. Spelsberg, John R. Hawse, Steven A. Johnsen. Krüppel-like Transcription Factor-10 (KLF10) suppresses the TGFβ-induced epithelial-to-mesenchymal transition. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr A03.
P2-034: The molecular mechanism of Nm23-H1 gene transfection on reversing invasion and metastasis phenotype in human high-metastatic large cell lung cancer cell line L9981
Authors: Qinghua Zhou, Jun Chen, Wen Zhu, Daxing Zhu, Guowei Che, Qin Yang, Zhilin Sun
Journal: Journal of Thoracic Oncology (2007)
Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. Meta-analysis Group In Cancer.
Authors: P Piedbois, P Rougier, M Buyse, J Pignon, L Ryan, R Hansen, B Zee, B Weinerman, J Pater, C Leichman, J Macdonald, J Benedetti, J Lokich, J Fryer, G Brufman, R Isacson, A Laplanche, E Levy
Journal: Journal of Clinical Oncology (1998)

PURPOSE The administration of fluorouracil (5-FU) by continuous intravenous infusion (CI) is an alternative to the bolus administration of 5-FU in patients with advanced colorectal cancer. Although more than 1,200 patients have been enrolled onto randomized trials that compared these two treatment modalities, there is still no definitive evidence of an advantage of 5-FU CI, and the magnitude of this advantage, if any, is also controversial. A meta-analysis was performed to assess this benefit in terms of tumor response and survival, and to compare the toxicity profiles of these two modalities of administration of 5-FU. DESIGN Individual data of 1,219 patients included in six randomized trials served as the basis for this meta-analysis, which was conducted by an independent secretariat in close collaboration with the investigators. RESULTS Tumor response rate was significantly higher in patients assigned to 5-FU CI than in patients assigned to 5-FU bolus (22% v 14%; overall response odds ratio, 0.55; 95% confidence interval [95% CI], 0.41 to 0.75; P = .0002). Overall survival was also significantly higher in patients assigned to 5-FU CI (overall hazards ratio [HR], 0.88; 95% CI, 0.78 to 0.99; P = .04), although the median survival times were close. Multivariate analyses showed that randomized treatment and performance status were the only two significant predictors of tumor response, whereas the same plus primary tumor site were independent significant predictors of survival (patients with rectal cancer did somewhat better). Grade 3 or 4 hematologic toxicity was more frequent in patients assigned to 5-FU bolus (31% v 4%; P &lt; 10(-16)), whereas hand-foot syndrome was more frequent in the 5-FU CI group (34% v 13%; P &lt; 10(-7)). CONCLUSION 5-FU CI is superior to 5-FU bolus in terms of tumor response and achieves a slight increase of overall survival. The hematologic toxicity is much less important in patients who receive 5-FU CI, but hand-foot syndrome is frequent in this group of patients.
Comment on Methodology and Interpretation of Results
Authors: Alain F. Pelfrene
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Comment on Methodology and Interpretation of Results Get access Alain F. Pelfrene Alain F. Pelfrene Director of the Division of Product Safety Assessment Centre de Recherche Searle 06560 Valbonne, France Department of Pathology-Toxicology Searle LaboratoriesBox 4110 Chicago, Illinois 60680 Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 3, March 1977, Pages 475–476, https://doi.org/10.1093/jnci/58.3.475 Published: 01 March 1977
Gabapentin in the treatment of bipolar disorder
Authors: C B Schaffer, L C Schaffer
Journal: American Journal of Psychiatry (1997)

Gabapentin, a relatively new anti-epileptic drug (liED), is emerging as a therapeutic option JOr treatment refractory and rapid-cycling bipolar illnesses.Pharmacotherapy JOr bipolar disorders traditionally involves oalproate, carbamazapine, or lithium, drugs which are associated with numerous adverse effects.Conversely, gabapentin has an attractive pharmacokinetics profile and relativelyje w side effects.There are no large randomizedcontrolled clinical trials to date examining gabapentin's role in mood stabilization.However, informal reports have cited encouraging results in up to 80% ifpatients and general tolerance to side ifJects.Thesefin dings make the new drug a possible choicefor patients who haveJailed to respond to traditional agents or developed side effects which interfere with medication compliance.
Tissue Factor Induced by Epithelial–Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells
Authors: Morgane Bourcy, Meggy Suarez-Carmona, Justine Lambert, Marie-Emilie Francart, Hélène Schroeder, Céline Delierneux, Nicolas Skrypek, Erik W. Thompson, Guy Jérusalem, Geert Berx, Marc Thiry, Silvia Blacher, Brett G. Hollier, Agnès Noël, Cécile Oury, Myriam Polette, Christine Gilles
Journal: Cancer Research (2016)

Epithelial-mesenchymal transition (EMT) is prominent in circulating tumor cells (CTC), but how it influences metastatic spread in this setting is obscure. Insofar as blood provides a specific microenvironment for tumor cells, we explored a potential link between EMT and coagulation that may provide EMT-positive CTCs with enhanced colonizing properties. Here we report that EMT induces tissue factor (TF), a major cell-associated initiator of coagulation and related procoagulant properties in the blood. TF blockade by antibody or shRNA diminished the procoagulant activity of EMT-positive cells, confirming a functional role for TF in these processes. Silencing the EMT transcription factor ZEB1 inhibited both EMT-associated TF expression and coagulant activity, further strengthening the link between EMT and coagulation. Accordingly, EMT-positive cells exhibited a higher persistance/survival in the lungs of mice colonized after intravenous injection, a feature diminished by TF or ZEB1 silencing. In tumor cells with limited metastatic capability, enforcing expression of the EMT transcription factor Snail increased TF, coagulant properties, and early metastasis. Clinically, we identified a subpopulation of CTC expressing vimentin and TF in the blood of metastatic breast cancer patients consistent with our observations. Overall, our findings define a novel EMT-TF regulatory axis that triggers local activation of coagulation pathways to support metastatic colonization of EMT-positive CTCs. Cancer Res; 76(14); 4270-82. ©2016 AACR.