tbuckley/cabot-search huggingface dataset:
Abstract 3123: Differential effects of polyoma virus middle tumor antigen mutants upon gap junctional, intercellular communication
Authors: Samantha N. Greer, Mulu Geletu, Leda H. Raptis
Journal: Cancer Research (2011)

Abstract Gap junctions are channels that connect the cytoplasm of adjacent cells. Gap junctional, intercellular communication (GJIC) is blocked in cells transformed by oncogenes such as the middle Tumor antigen of polyoma virus (mT), an oncoprotein which associates with and is tyrosine-phosphorylated by cSrc family members. Specific phosphotyrosines provide docking sites for the phosphotyrosine binding domain of Shc (mT-tyr250) and the SH2 domain of the phosphatidylinositol 3-kinase (mT-tyr315), resulting in the activation of their downstream signaling cascades, Ras/Raf/Erk and PI-3 kinase/Akt, respectively. To examine the effect of these mT-initiated pathways upon gap junctional communication and neoplasia, GJIC was assessed in mT-mutant-expressing, rat liver epithelial T51B cells which normally have extensive GJIC, using a novel technique of in situ electroporation we developed. The results show that although low levels of wt-mT are sufficient to interrupt gap junctional communication, GJIC suppression still requires an intact tyr250 site, that is activation of the Ras pathway. In sharp contrast, activation of the PI-3 kinase pathway is not required for GJIC suppression. It is remarkable that T51B cells expressing a mutant deficient in binding of Shc, hence activation of the Ras pathway, are still morphologically transformed and do grow into tumors in syngeneic rats, albeit with an altered morphology. These results indicate that GJIC suppression requires Ras/Erk but not PI-3 kinase/Akt signalling, and is independent of neoplastic conversion in rat liver epithelial cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3123. doi:10.1158/1538-7445.AM2011-3123
Monoclonal Antibodies to Watch
Authors: C. McNeil
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Monoclonal Antibodies to Watch Get access Caroline McNeil Caroline McNeil Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 22, 15 November 1995, Page 1659, https://doi.org/10.1093/jnci/87.22.1659 Published: 15 November 1995
Abstract 2110: An attempt to replicate the results of genome-wide association studies on lung cancer susceptibility loci in a Korean population
Authors: Hyo-Gyoung Kang, Eun Young Bae, Shin Yup Lee, Hyo-Sung Jeon, Jae Yong Park
Journal: Cancer Research (2012)

Abstract Genome-wide association studies (GWASs) have identified three chromosomal regions at 5p15, 6p21, and 15q25 as being associated with lung cancer risk in European populations. This study was performed to confirm these associations in Korean patients with lung cancer. The genotypes of rs2736100, rs402710, rs401681, and rs31489 at 5p15, rs9295740 at 6p22, and rs2036534 and rs6495309 at 15q25 were determined in 1094 lung cancer patients and 1100 healthy controls frequency-matched for age and gender. The single nucleotide polymorphisms (SNPs) at 5p15 and 15q25 were significantly associated with lung cancer risk. The magnitude of effect was similar to that reported in previous studies and the association was in the same direction. The effect of SNPs at 5p15 region on the risk of lung cancer was significant only in adenocarcinoma. The two SNPs at 15q25 region were significantly associated with lung cancer risk in ever-smokers and squamous cell carcinoma. However, there was no association between the SNP at 6p22 and lung cancer risk. We confirmed the association between SNPs at the 5p15 and 15q25 regions and the risk of lung cancer in a Korean population. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2110. doi:1538-7445.AM2012-2110
Abstract 862: Network patient navigation: An integrative, longitudinal model to reduce breast cancer disparities
Authors: Steven R. Patierno, Nancy L. LaVerda, Lisa M. Alexander, Ed D., Paul H. Levine, Heather A. Young, Heather J. Hoffman
Journal: Cancer Research (2010)

Abstract Introduction: Minority breast cancer mortality rates in Washington, DC are among the nation's highest. To address disparities we instituted the DC Citywide Patient Navigation Research Program (DC-PNRP) - an inter-institutional collaboration that is one of 9 National PNRP sites funded by NCI/ACS to evaluate the effectiveness of patient navigation in reducing barriers to obtaining health care while also addressing psychosocial factors. Study Procedures: More than 1000 minority women have been enrolled from 7 recruitment sites at the point of suspicious finding to investigate whether patient navigation decreases time from suspicious breast finding to diagnostic resolution and time from diagnosis to treatment initiation. Utilizing a non-randomized design, concurrent, medical records-based controls have been identified. Data collection will extend through March 2010. A unique framework of “network navigation” emerged whereby services were integrated across a city-wide network of unaffiliated healthcare sites. Navigators from a broad partnership of clinical and community sites were trained to work collaboratively within a city-wide network to enroll patients in the study and assure each patient receives timely, quality care. This “integrative navigation” model is collecting data addressing not only structural barriers to access to care (i.e., inadequate insurance, lack of transportation, etc.), but also psychosocial barriers (i.e., fear, medical mistrust, acculturation, etc.). Frequent trainings, efforts that promote increased communication between navigators, and sharing of information about community resources were implemented to enhance care coordination and to assure appropriate referral strategies between community outreach, screening, and treatment sites. Results and Conclusion: Implementation of DC-PNRP led us to broaden the original treatment-oriented navigation model to create a “Longitudinal Navigation” paradigm that follows the patient from outreach through survivorship. Data will be shown describing how this model addresses barriers to access and the underlying fragmentation of services that exist in DC for low-income uninsured or under-insured women. Data on the types and distribution of barriers will also be presented. This city-wide program serves as model for inter-institutional cooperation to improve health care access, particularly for the underserved. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 862.
CLINICAL OUTCOMES OF PATIENTS UNDERGOING PERCUTANEOUS CORONARY CHRONIC TOTAL OCCLUSION INTERVENTIONS: A WEIGHTED META-ANALYSIS OF 28,486 PATIENTS FROM 25 STUDIES
Authors: Georgios Christakopoulos, Georgios Christopoulos, Mauro Carlino, Omar Jeroudi, Michele Roesle, Bavana Rangan, Shuaib Abdullah, Jerrold Grodin, Dharam Kumbhani, Minh Vo, Michael Luna, Khaldoon Alaswad, Dimitrios Karmpaliotis, Stéphane Rinfret, Santiago Garcia, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2015)
Retrospective Study of Chemotherapy in Lung Cancer Patients Complicated Interstitial Pneumonia
Authors: Y. Ueda, H. Yamasita, K. Tomita, T. Kosyoubu, S. Yoshimasa, H. Kazunori, R. Hamazoe, T. Sakamoto, M. Morita, E. Shimizu
Journal: Annals of Oncology (2013)
P678S-glutathiolation of cMyBP-C reduces its phosphorylation and contributes to impairment of cardiac myocyte contractile function
Authors: K Stathopoulou, N Boontje, F Buck, E Schroeder, N Voigt, D Dobrev, J Van Der Velden, T Eschenhagen, L Carrier, F Cuello
Journal: Cardiovascular Research (2014)

Background: Cardiac myosin-binding protein C (cMyBP-C) is a thick filament-associated protein involved in the regulation of contraction and relaxation and thus in vivo cardiac performance. Phosphorylation of cMyBP-C within the N-terminal M-domain promotes actin-myosin interaction and accelerates cross-bridge cycling kinetics, ultimately required for enhancing rates of relaxation and force generation in diastole and systole, respectively. In myocardial samples from patients with heart failure, a condition where contractility is impaired, phosphorylation of cMyBP-C is decreased. Disease conditions are also associated with increased production of reactive oxygen species (ROS), contributing to alterations in contractile performance by inducing oxidative posttranslational modifications (OPTMs) in target proteins.
COMPARISON OF SHORT- AND LONG-TERM MORTALITY BETWEEN ST-SEGMENT ELEVATION AND NON-ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION
Authors: Hidenori Yaku, Hiroki Shiomi, Takeshi Morimoto, Yugo Yamashita, Yutaka Furukawa, Yoshihisa Nakagawa, Kenji Ando, Kazushige Kadota, Mitsuru Abe, Miki Shinji, Satoshi Shizuta, Koh Ono, Takeshi Kimura
Journal: Journal of the American College of Cardiology (2016)
SAT0278 The Comparison of Diagnostic Accuracy between Eular/Acr Provisional Classification for PMR and Other Criterion
Authors: M. Yokoe
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Polymyalgia rheumatica (PMR) is a common rheumatic disorder in the elderly population. General Internal Medicine doctors often encounter these patients. However, the gold standard for the diagnosis of PMR is nonexistent. Recently, new classification criteria for PMR have been presented by ACR and EULAR. Exactly using the ultrasound to diagnose PMR, it is well known that specificity will be improved. However, all general physicians do not have assured techniques of joint power Doppler ultrasonography. This time, we compared the diagnostic accuracy between EULAR/ACR classification (scoring algorithm without Ultrasound -3 required criteria) and Bird criteria, Chuang criteria and Kyle criteria for PMR. <h3>Objectives</h3> To investigate the diagnostic accuracy including sensitivity and specificity of each criterion. The objectives were 48 cases of PMR that had been started PSL therapy with the 3 positive factors or more on Bird criteria during June 2008 to May 2013. <h3>Methods</h3> Forty-eight cases were evaluated retrospectively and coefficient of agreement. In addition, discriminant analysis was performed on 4 criteria. <h3>Results</h3> In total 48 patients, 30 patients (62.5%) were female. Average age was 75.4±8.5 years old (48-89yo). As same as EULAR/ACR study design, we decided final diagnosis of PMR after 26 weeks starting steroid treatment. Finally, PMR cases are 41 and Non-PMR cases are 7cases (Prevalence: 85.4%). All 48 cases are matched for Bird criteria. Four cases had not examined ACPA and RF at initial diagnosis, EULAR/ACR classification was adapted 44 cases (Prevalence 84.1%). Table 1 shows the comparison of the diagnostic accuracy and coefficient of agreement of 3 criteria. Table 2 shows the results of discriminant analysis. <h3>Conclusions</h3> EULAR/ACR provisional classification had better performance than the other PMR criterion with a statistically significant. This study did not include a lot of control case, high prevalence prevented from having a high matching coefficient κ(kappa) value on EULAR/ACR classification. From the discriminant analysis, EULAR/ACR classification had a high discriminant probability with 83%. At the present moment, EULAR/ACR classification is the most reliable criteria for PMR. <h3>References</h3> Dasgupta B, Cimmino MA, Maradit-Kremers H, et al. 2012 provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative. Ann Rheum Dis. 2012 Apr;71(4):484-92. Bird HA, Esselinckx W, Dixon AS, et al. An evaluation of criteria for polymyalgia rheumatica. Ann Rheum Dis. 1979 Oct;38(5):434-9. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2561
Abstract 1873: Low-dose radiation exposure and the risk of developing acoustic neuroma
Authors: Yueh-Ying Han, Oren Berkowitz, Maryann Donovan, Evelyn Talbott
Journal: Cancer Research (2011)

Abstract Aside from the rare hereditary syndrome of Neurofibromatosis type 2 or high-dose ionizing radiation exposure, the causes of the vast majority of acoustic neuroma development remain unclear. A hospital-based case-control study was conducted to investigate the roles of exposure to commonly used diagnostic tools and phone technology that emit low dose ionizing and non-ionizing radiation in the etiology of acoustic neuroma. A total of 353 cases were recruited from a cohort of individuals who underwent Gamma Knife Radiosurgery as primary or adjuvant management of acoustic neuroma between the years 1997-2007 at the Center for Image Guided Neurosurgery, University of Pittsburgh Medical Center (UPMC). Matched by age and gender, 353 controls without brain tumor history were recruited from the Neurosurgery spine and pain clinics at UPMC. Information on demographic characteristics, medical exposure to radiation, use of cell phone, and other potential risk factors of acoustic neuroma were collected via questionnaire by trained interviewers at clinics. Conditional multivariate logistic regression was used to calculate the odds ratio (OR) and 95% confidence interval (CI) to assess risk of acoustic neuroma associated with low-dose radiation exposure. Adjusted for education, smoking, drinking, occupational exposure to noise, previous history of head injury, and family history of cancer, exposure to dental x-ray every 2-3 years and at least once a year was significantly associated with development of acoustic neuroma compared to individuals exposed to dental x-ray less than once every five years (OR=3.57, 95% CI = 1.54-8.23 and OR=2.31, 95% CI=1.06-5.04, respectively). History of full mouth or panorax X-ray exam (OR=1.35, 95% CI=0.76-2.41), CAT or CT scan of head or neck (OR=0.61, 95% CI=0.30-1.23), and other X-ray exam of head or neck (OR=0.77, 95% CI=0.41-1.45) were not found to be related to development of acoustic neuroma. Use of cell phones or cordless phones for more than 10 years was not significantly associated with development of acoustic neuroma (OR=1.30, 95% CI=0.53-3.20 and OR=1.20, 95% CI=0.43-3.37, respectively). We found that frequent exposure to dental X-rays may contribute the development of acoustic neuroma, although does-response effect was not found. Further epidemiologic studies are necessary to confirm the association of diagnostic dental X-rays exposure and development of acoustic neuroma. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1873. doi:10.1158/1538-7445.AM2011-1873
VTD is superior to VCD prior to intensive therapy in multiple myeloma: results of the prospective IFM2013-04 trial
Authors: Philippe Moreau, Cyrille Hulin, Margaret Macro, Denis Caillot, Carine Chaleteix, Murielle Roussel, Laurent Garderet, Bruno Royer, Sabine Brechignac, Mourad Tiab, Mathieu Puyade, Martine Escoffre, Anne-Marie Stoppa, Thierry Facon, Brigitte Pegourie, Driss Chaoui, Arnaud Jaccard, Borhane Slama, Gerald Marit, Karim Laribi, Pascal Godmer, Odile Luycx, Jean-Claude Eisenmann, Olivier Allangba, Mamoun Dib, Carla Araujo, Jean Fontan, Karim Belhadj, Marc Wetterwald, Véronique Dorvaux, Jean-Paul Fermand, Philippe Rodon, Brigitte Kolb, Sylvie Glaisner, Jean-Valere Malfuson, Pascal Lenain, Laetitia Biron, Lucie Planche, Helene Caillon, Herve Avet-Loiseau, Thomas Dejoie, Michel Attal
Journal: Blood (2016)
Abnormal Glucose Counterregulation after Subcutaneous Insulin in Insulin-Dependent Diabetes Mellitus
Authors: Geremia B. Bolli, George D. Dimitriadis, Gregory B. Pehling, Barbara A. Baker, Morey W. Haymond, Philip E. Cryer, John E. Gerich
Journal: New England Journal of Medicine (1984)

We assessed glucose counterregulation during intensive insulin therapy in 20 patients with insulin-dependent diabetes mellitus (IDDM) by injecting therapeutic doses of regular insulin subcutaneously after overnight maintenance of euglycemia. As compared with nondiabetic controls matched for age and weight, 17 of the patients had more severe and more prolonged hypoglycemia (nadir, 42 +/- 2 in patients vs. 60 +/- 2 mg per deciliter in controls P less than 0.01; duration, 6.2 +/- 0.4 vs 2.1 +/- 0.6 hours, P less than 0.01). Most patients had decreased responses of several counterregulatory hormones. Marked rebound hyperglycemia (approximately equal to 300 mg per deciliter) ultimately developed in 11 patients. The only features distinguishing patients with rebound hyperglycemia from those without it were plasma free insulin concentrations during recovery from hypoglycemia (those with vs. those without, 7 +/- 1 vs. 22 +/- 2 microU per milliliter, P less than 0.01) and insulin-antibody binding (5 +/- 1 vs. 30 +/- 5 per cent, P less than 0.01). Rates of plasma glucose recovery from hypoglycemia were inversely correlated with plasma free insulin concentrations (r = -0.84, P less than 0.01); the latter in turn were directly correlated with insulin-antibody binding (r = 0.94, P less than 0.01). We conclude that many patients with IDDM have impaired glucose counterregulation due to multiple defects in counterregulatory-hormone secretion. This is associated with increased insulin-antibody binding, which prolongs the half-life of insulin. In such patients, intensive insulin therapy may be hazardous.
1379 NON-HIGH DENSITY LIPOPROTEIN CHOLESTEROL (non HDL-C) INDEPENDENTLY PREDICTS NEW ONSET OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) IN A 7 YEAR PROSPECTIVE FOLLOW-UP
Authors: S. Zelber-Sagi, R. Lotan, M. Webb, Z. Halpern, E. Santo, R. Oren, O. Shibolet
Journal: Journal of Hepatology (2013)
Regulation of appetite and cholecystokinin secretion in anorexia nervosa
Authors: T D Geracioti, R A Liddle, M Altemus, M A Demitrack, P W Gold
Journal: American Journal of Psychiatry (1992)

Six patients with anorexia nervosa, the same patients after weight normalization, and six healthy control subjects had similar fasting and postprandial plasma cholecystokinin concentrations. These data do not support the hypothesis that low levels of hunger and food intake in anorexic patients reflect hypersecretion of this endogenous hormone, which is thought to inhibit hunger, promote satiety, and reduce feeding.
Abstract 4624: High affinity CD3 RECRUIT-TandAbs for T cell-mediated lysis of malignant CD19+ B cells
Authors: Uwe Reusch, Carmen Burkhardt, Stefan H. Knackmuss, Ivica Fucek, Markus Eser, Fionnuala McAleese, Thomas Gronewold, Eugene Zhukovsky, Melvyn Little
Journal: Cancer Research (2012)

Abstract The TandAb technology enables the development of innovative antibody therapeutics for improved treatment of various diseases. This platform has been primarily applied to oncology and comprises of CD3 RECRUIT- and CD16A RECRUIT-TandAbs for activation of T and NK effector cells, respectively, and lysis of target cells expressing specific surface antigens. The CD3 RECRUIT-TandAb AFM11 is a human bispecific tetravalent antibody with two binding sites for the α-chain of CD3 and two binding sites for CD19. CD19 is expressed at early stages of B cell development and persists until the final differentiation into plasma cells. Thus, CD19 represents an attractive target for the treatment of various B cell malignancies including leukemias and lymphomas that lack CD20 expression or are refractory to anti-CD20 antibody therapies. In vitro cytotoxicity assays employing tumor cell lines demonstrate high potency of AFM11 in mediating target cell lysis: EC50 values are in the low to sub-picomolar range depending on CD19+ target cell lines and primary B-CLL tumor cells. Cytotoxic activity of tetravalent AFM11 is superior to those of alternative bivalent antibody formats. High affinity binding of AFM11 to CD3 and CD19 (low to sub-nanomolar range) contributes to efficacious T cell recruitment. This binding was determined by flow cytometry and by a label-free biosensor that measures real-time binding kinetics on live cells. Therapeutic recruitment of T cells has a potential for a devastating cytokine release if it results not in a site-specific but rather systemic activation. Thus, functional in vitro assays were used to demonstrate that high affinity and bivalent binding of AFM11 to CD3 is not sufficient for triggering activation signals in T cells. AFM11 activates T cells only in the presence of CD19+ target cells, and specifically mediates lysis of these cells without affecting antigen-negative bystander cells. In the absence of target cells and at high concentrations AFM11 induces down-modulation of the CD3/TCR complex from the surface of T cells. The latter may contribute additional safety to therapeutic potential of CD3 RECRUIT-TandAbs without affecting the efficacy, since AFM11-treated T cells can be re-engaged for target cell lysis. In vivo AFM11 demonstrated a robust dose-dependent inhibition of tumor growth in a study with Raji xenografts in NOD/scid mice and reconstituted human PBMC. Altogether, these data suggest that AFM11 is a highly efficacious novel drug candidate for the treatment of hematological malignancies and displays an advantageous safety profile. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4624. doi:1538-7445.AM2012-4624
New centre sets out to better coordinate research into non-communicable diseases
Authors: M. Limb
Journal: BMJ (2012)

A global initiative designed to strengthen research into non-communicable diseases and improve collaboration between rich and poorer countries has been launched in London.

The Centre for Global Non-Communicable Diseases at the London School of Hygiene and Tropical Medicine aims to foster new studies and ensure research evidence is acted upon by policymakers.

Neil Pearce, its director, said, “Non-communicable diseases are becoming incredibly important globally, and while there’s a lot happening it’s not particularly well coordinated.

“We need researchers in different diseases and different countries—low, middle income, and high income—to communicate more with each other. We can …
18F-FDG PET/CT Finding of Bilateral Primary Breast Mucosa-Associated Lymphoid Tissue Lymphoma
Authors: Do-Hoon Kim, Ji Yun Jeong, Sang-Woo Lee, Jaetae Lee, Byeong-Cheol Ahn
Journal: Clinical Nuclear Medicine (2014)

Primary breast lymphoma is an extremely rare disease. Primary breast mucosa-associated lymphoid tissue (MALT) lymphoma is even rarer, and bilateral involvement is exceptional. We report on the F-FDG PET/CT findings in a patient with primary bilateral breast MALT lymphoma. F-FDG PET/CT showed hypermetabolic masses in both breasts. The patient was confirmed with bilateral primary breast MALT lymphoma after total mastectomy. Despite its rarity, primary breast MALT lymphoma should be considered in patients with hypermetabolic masses in the breast. If primary breast MALT lymphoma is suspected, F-FDG PET/CT is a useful tool for initial staging in patients.