tbuckley/cabot-search huggingface dataset:
Abstract 10293: Regional Right Ventricular Dysfunction in Acute Pulmonary Embolism Associated With Increased Clot Burden and Greater RV Dysfunction
Authors: Mirela Tuzovic, Sasikanth Adigopula, Myriam Amsallem, Yukari Kobayashi, David Boulate, Gomathi Krishnan, David Liang, Ingela Schnittger, Michael V McConnell, François Haddad
Journal: Circulation (2015)

Introduction: Regional right ventricular (RV) dysfunction (RRVD) is an echocardiographic feature in acute pulmonary embolism (PE), primarily reported in patients with moderate-to-severe RV dysfunction. We assessed the hypothesis that RRVD is associated with increased burden of PE and greater RV dysfunction. Methods: We identified all consecutive patients admitted at Stanford’s emergency department between 1999 and 2014 who underwent both computed tomographic angiography, echocardiography, and biomarker testing (troponin and NT-proBNP) within 2 days of each other for suspected acute PE, in order to investigate the relationship between RRVD, PE clot burden, RV size/function, and biomarkers. Patients with PE were divided according to clot burden as follows: central or multilobar PE versus peripheral PE. RRVD was defined as normal excursion of the apex contrasting with hypokinesis of the mid-free wall segment. RV function was assessed by fractional area change and free-wall longitudinal strain. Echocardiograms were also assessed for reproducibility. Results: Eighty-two patients were included (mean age 66 ±17 years, 43% male, 51 with acute PE). RRVD was present in 41% of PEs and absent in all patients without PE. Eighty-six percent (86%) of patients with RRVD had central or multi-lobar PE. Patients with RRVD had higher prevalence of moderate-to-severe RV dilation (81% vs. 30%, p&lt;0.01) and dysfunction (86% vs. 23%, p&lt;0.01). Troponin level was positive in 38% of patients with RRVD versus 13% in PE without RRVD (p=0.08), while the NT-proBNP level was positive in 67% versus 73% (p=0.88), respectively. RRVD showed excellent concordance between readers (87%). Conclusion: The “McConnell sign” of RRVD is a reproducible finding associated with an increased clot burden and greater degree of RV dysfunction in patients with acute PE.
Soundings: Society column
Authors: James Owen Drife
Journal: BMJ (1999)

September is the conference month. For politicians this means soundbites by the sea but health workers are less ostentatious. Across the country university halls of residence are almost—but not quite—cleared of drawing pins, bits of adhesive putty, and peremptory notices before being filled by carers with name badges.

Everyone agrees that the most useful part of any conference is the social interaction. No organiser, however, carries this to its logical conclusion by dispensing with talks and simply keeping the bar open day and night. A formal programme is necessary and this means speakers. We academics cheerfully help. We understand. We were meetings secretaries ourselves once.

What surprises us is the diversity. Every subspecialty, every part of the body, and almost every practical procedure now has a society. Those whose members use expensive equipment meet in posh hotels. Some societies are exclusively medical but many include scientists and nurses. In general, the smaller the proportion of doctors, the jollier the society.

Some are female with only an occasional male accompanying person. Compared with men’s the speeches of female chairpersons are shorter, friendlier, more poised, and better prepared. All-female societies are happy to hire a discotheque for the sheer pleasure of dancing together after dinner. In my experience, all-male societies have reservations about this.

We outside speakers need podium savvy. When asked to fax the chairman a curriculum vitae, we keep it as brief as possible, remembering times when the full version was read out verbatim.

Though we prepare carefully, reality becomes apparent only on the day. Outside the venue, yellow AA signs give us mild tachycardia. Inside, we assess the atmosphere. Sometimes it is evangelical and we recognise how to evoke either hisses or murmurs of approval. We then have to decide whether to stir things up or opt for a quiet life.

Sometimes we are invited to stay and be amusing after dinner. This is challenging. Humour is based on shared experience and the speaker is an outsider. Many societies have a guru—a senior figure, perhaps even a founder. Members pulling his or her leg are met with general hilarity and a tolerant smile from the guru but no visitor should attempt this. Rely on self deprecation if you want to be asked back.
Lecithin in the treatment of Gilles de la Tourette's syndrome
Authors: H Moldofsky, P Sandor
Journal: American Journal of Psychiatry (1983)

Five patients with Tourette's syndrome were administered a mean dose of 512 mg/kg per day of oral lecithin. None of the patients exhibited sustained clinical improvement in symptom severity. No significant changes in serum prolactin or growth hormone were observed during lecithin administration.
Transition care with telemonitoring did not reduce readmission after hospitalization for heart failure
Authors: Harriette G.C. Van Spall
Journal: Annals of Internal Medicine (2016)

Source Citation Ong MK, Romano PS, Edgington S, et al; Better Effectiveness After Transition–Heart Failure [BEAT-HF] Research Group. Effectiveness of remote patient monitoring after discharge of hospitalized patients with heart failure: the Better Effectiveness After Transition-Heart Failure (BEAT-HF) randomized clinical trial. JAMA Intern Med. 2016;176:310-8. 26857383
AG-348 Activation of Pyruvate Kinase in Vivo Enhances Red Cell Glycolysis in Mice
Authors: Charles Kung, Collin Hill, Yue Chen, Abhishek Jha, Penelope Kosinski, Michelle Clasquin, Yaguang Si, Hyeryun Kim, Jeff Hixon, Lenny Dang, Sam Agresta, Lee Silverman, Hua Yang
Journal: Blood (2014)
Where the item still rules supreme: Time-based selection, enumeration, pre-attentive processing and the target template?
Authors: Derrick G. Watson
Journal: Behavioral and Brain Sciences (2017)

Abstract I propose that there remains a central role for the item (or its equivalent) in a wider range of search and search-related tasks/functions than might be conveyed by the article. I consider the functional relationship between the framework and some aspects of previous theories, and suggest some challenges that the new framework might encounter.
Pigmented Villonodular Synovitis
Authors: Stephen M. Broski, Nathan M. Murdoch, John A. Skinner, Doris E. Wenger
Journal: Clinical Nuclear Medicine (2015)

This study evaluated the semiquantitative and qualitative appearance of pigmented villonodular synovitis (PVNS) and giant cell tumor of the tendon sheath (GCTTS) on 18F-FDG PET/CT.An institutional review board-approved retrospective review was performed for patients diagnosed with GCTTS, focal PVNS, or diffuse PVNS who underwent PET/CT from 2003 to 2013. SUVmax and SUVmax/SUVmean of the liver (SUVr) were determined for each lesion on all available PET/CTs. Relevant conventional imaging and patient records were reviewed.Fourteen patients (mean [SD] age, 52.8 [14.0] years; range, 26-74 years) were identified, 6 with 2 or more PET/CT examinations. The mean (SD) SUVmax and SUVr of all lesions were 8.7 (3.4; range, 4.0-14.5) and 3.9 (1.7; range, 2.0-7.1), respectively. There was no difference of the mean (SD) SUVmax (P = 0.10) or SUVr (P = 0.11) between focal PVNS (6.8 [3.0], 3.3 [1.9]), GCTTS (9.1 [3.0], 4.0 [1.2]), or diffuse PVNS (14.5, 7.1) subtypes. Of 29 comparison PET/CTs in 6 patients, 17 were performed after nontargeted chemotherapy and 12 without antecedent therapy. Significant SUVr fluctuations (>25%) occurred in 11 cases; no correlation existed between SUVr change and presence or absence of chemotherapy.Pigmented villonodular synovitis and GCTTS can be intensely hypermetabolic, mimicking musculoskeletal metastases on 18F-FDG PET/CT. They may have significant SUV fluctuations, both during nontargeted chemotherapy and between treatments. The diagnosis of PVNS/GCTTS should be considered for focal intra-articular or juxta-articular FDG-avid lesions, and MRI is useful in further evaluation given the often diagnostic imaging features with this modality.
18F-DOPA PET/CT and MRI Findings in a Patient With Multiple Meningiomas
Authors: Ferdinando F. Calabria, Agostino Chiaravalloti, Eros N. Calabria, Giovanni Grillea, Orazio Schillaci
Journal: Clinical Nuclear Medicine (2016)

A 56-year-old man was referred to our Department for a 2-year story of upper limb tremor, severe headache, and episodes of confusion. Brain F-DOPA PET/CT showed multiple areas of tracer uptake in the two hemispheres of the brain. Subsequent MRI displayed demyelinating foci with high contrast enhancement. Histological specimen confirmed the diagnosis of multiple meningiomas.
Tularaemia outbreak in Castilla y León, Spain, 2007: an update
Authors: M Allue, C Ruiz Sopeña, M T Gallardo, L Mateos, E Vian, M J Garcia, J Ramos, A C Berjon, M C Viña, M P Garcia, J Yanez, L C Gonzalez, T Munoz, C Andres, S Tamames, C Ruiz, L A Gómez Iglesias, J Castrodeza
Journal: Eurosurveillance (2008)

Binary file ES_Abstracts_Final_ECDC.txt matches
Abstract P1-07-10: Increasing population rates of in-situ breast cancer [DCIS] are associated with reduced breast cancer (BrCa) mortality. A case for screening mammography and "overdiagnosis" linked to outcome benefits
Authors: J Ragaz, H Qian, S Shakeraneh, J Fox, KS Wilson, JS Simpson, J-Y Yoon, H Wong
Journal: Cancer Research (2016)

Abstract INTRODUCTION: Following the first phase of this project [Ref 1], we correlate here the rates of DCIS with BrCaMOR, in two regions of Canada - British Columbia [BC] and Atlantic Provinces [Atl.P]. We previously reported higher compliance in screening mammography [ScreenMam] and therapeutic [TH*] guidelines [GUIDELINES] for both DCIS and invasive BrCa in BC compared with Atl.P [Ref. 2]. METHODS: Annual age-specific rates [cases / 100,000 population] of DCIS, and BrCaMOR between BC vs Atl.P, were obtained for 17 age groups of 5 years (years 0-4 to 85+) and averaged each 5-year period from 1975-1979 up to 2005-2009. To compare age distribution, DCIS rates and BrCaMOR between the two regions, we selected four birth cohorts, age 30-34, 35-39, 40-44 and 45-49 in 1975-1979. From those, we tabulated the DCIS incidence and BrCaMOR for each birth cohort when they reached ages 50-54 and 60-64. We assumed that the rates of DCIS reflect annual ScreenMam practices. Data were obtained from the Public Health Agency of Canada based on the Canadian Cancer Registry database at Statistics Canada. RESULTS [N/100,000 population]British ColumbiaAtlantic ProvincesAge / years DCISBrCaMORDCISBrCaMORAge 50 â– 54 1980-8413.152.24.056.41985-8921.246.68.056.11990â–9429.244.421.449.91995â–9945.543.830.050.1Age 60â – 64 1990-9428.072.123.186.21995-9949.361.935.276.62000-0449.365.845.669.42005â–0951.453.141.059.4 CONCLUSIONS: 1. Our study shows across all age cohorts higher rates of DCIS and lower BrCaMOR in BC compared to Atl.P - results consistent with higher ScreenMam rates in BC than Atl.P. 2. These data are compatible with the concept that a higher diagnostic rate for early lesions such as DCIS [i.e. frequently designated as "Overdiagnosis"] by ScreenMam, and subsequent earlier Guideline TH*, contributes to lower BrCaMOR. *TH Guidelines: surgery, radiation, Tamoxifen for DCIS; and the same + chemotherapy for early invasive disease. Citation Format: Ragaz J, Qian H, Shakeraneh S, Fox J, Wilson KS, Simpson JS, Yoon J-Y, Wong H. Increasing population rates of in-situ breast cancer [DCIS] are associated with reduced breast cancer (BrCa) mortality. A case for screening mammography and "overdiagnosis" linked to outcome benefits. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-07-10. References: 1. J. Ragaz, H. Wong, H. Qian, J.Fox, K. Wilson, A. Coldman: Cancer Research, May 1, 2015 75; P3-07-28 2. J. Ragaz, H. Wong, H. Qian: Cancer Research Feb 2010; 69(24 Supplement):2063-2063.
A Cohort Study Of 15,912 Patients On The Long-Term Quality Of Vka Therapy After Extreme Overanticoagulation
Authors: Hilde A.M. Kooistra, Nakisa Khorsand, Hanneke C. Kluin-Nelemans, Nic J.G.M. Veeger, Margriet Piersma, Karina Meijer
Journal: Blood (2013)
Selective depletion of bone marrow T lymphocytes with anti-CD5 monoclonal antibodies: effective prophylaxis for graft-versus-host disease in patients with hematologic malignancies
Authors: JH Antin, BE Bierer, BR Smith, J Ferrara, EC Guinan, C Sieff, DE Golan, RM Macklis, NJ Tarbell, E Lynch
Journal: Blood (1991)
Bristol inquiry
Authors: C. Dyer
Journal: BMJ (2001)

Between 30 and 35 children undergoing heart surgery at Bristol Royal Infirmary died between 1991 and 1995 who would probably have survived if treated elsewhere, the long awaited report into children's heart surgery at Bristol has concluded.

These “excess” deaths took place in a unit where mortality at the time for children aged under 1 was probably double that for England as a whole, and even higher for neonates. Around a third of children who underwent open heart surgery received less than adequate care.

The inquiry report, published last week, painted a picture of a flawed system of care with poor teamwork between professionals, “too much power in too few hands,” and surgeons who lacked the insight to see that they were failing and to stop operating.

But the failings were not those of the surgeons alone. An expert review of 80 cases carried out for the inquiry showed inadequacies at every point, from referral to diagnosis, surgery, and intensive care.

The physical setup was “dangerous,” with surgeons on one site—at the Royal Infirmary—and paediatric cardiologists several hundred …
Preliminary report on a crosswalk from DSM-III to ICD-9-CM
Authors: J W Thompson, D Green, H L Savitt
Journal: American Journal of Psychiatry (1983)

The wide use of DSM-III by clinicians and researchers in the United States has led to difficulties in reporting to federal agencies, which adhere to a policy supporting the use of ICD-9-CM. To rectify this situation, three federal agencies collaborated to design a translation, or "crosswalk," from DSM-III to ICD-9-CM. The authors discuss some of the differences between the two systems, describe the development of the crosswalk, and make suggestions concerning future nosological and statistical systems.
Abstract B37: Tumor heterogeneity contributes to anti-EGFR therapy resistance in glioblastoma
Authors: Ciro Zanca, Webster Cavenee, Frank Furnari
Journal: Cancer Research (2015)

Abstract Introduction: Glioblastoma is the most aggressive tumor type affecting the adult brain, with an overall patient survival from the time of diagnosis of about 15 months. Tumor promoting proteins such as EGFR (Epidermal Growth Factor Receptor) and its mutant form, EGFRvIII, are amplified in a subgroup of patients and have attracted attention as potential therapeutic targets. Unfortunately, kinase inhibition of EGFR or EGFRvIII has been proven to be ineffective due to resistance mechanisms that prevent the onset of cell death. Here we hypothesize that the presence of cytokines in the tumor microenvironment, in addition to their previously shown promotion of glioblastoma growth, also promote resistance to EGFR-directed therapies. To address this, we investigated core pathways known to protect cancer cells from induced cell death and tested novel treatment strategies of EGFR blockade in combination with inhibitors of cytokine-induced signaling effectors, activated by inter-clonal communication between heterogeneous tumor cell populations expressing EGFRvIII and EGFR. Experimental procedures: For these studies we used human and mouse glioma cell lines engineered to express wild type (wt) EGFR, EGFRvIII, or an analog-sensitive (as)-allele of EGFRvIII, as well as primary human glioma neurospheres expressing amplified EGFRvIII. Expression of cell death-related molecules was determined by RT-qPCR to identify potential survival factors regulated by conditioned medium (CM) produced from EGFRvIII-expressing glioma cells. Findings were validated in vivo by orthotopic engraftment of heterogeneous tumors and measurement of tumor burden by fluorescence molecular tomography technology during single and combined drug therapy regimens. Results and discussion: Previous results demonstrated that CM from EGFRvIII-expressing glioma cells enhances in vitro and in vivo growth of wtEGFR cells through an EGFRvIII-prompted IL-6/LIF paracrine mechanism. Here, our data indicate that EGFRvIII-CM additionally promotes resistance to EGFR inhibition in cells and tumors expressing wtEGFR. We show that IL-6/gp130-mediated signaling specifically promotes this resistance through mTORC2/NF-κB upregulation of the anti-apoptotic protein, Survivin (BIRC5). Blocking Survivin expression or pharmacologically inhibiting mTORC2 restores sensitivity to EGFR inhibitors. Conclusion: The mTORC2/NF-κB/Survivin axis promotes resistance to EGFR inhibitors in glioblastoma and nominates targeting this pathway as a means to enhance efficacy of EGFR blockade. Citation Format: Ciro Zanca, Webster Cavenee, Frank Furnari. Tumor heterogeneity contributes to anti-EGFR therapy resistance in glioblastoma. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr B37.
Abstract A51: DNA methylation in tumor, adjacent non-tumorous and normal breast tissues
Authors: Erin Wagner, Wenting Wu, Yunlong Liu, Kenneth Nephew, Jiali Han, Chunyan He
Journal: Cancer Research (2016)

Abstract DNA methylation is an essential epigenetic mechanism involved in gene regulation. Aberrant DNA methylation plays an important role in breast cancer initiation and progression via inactivation of tumor suppressor genes and activation of oncogenes. Conventional approaches comparing DNA methylation profiles in tumor and adjacent non-tumorous tissue have shown that changes in DNA methylation contribute to deregulation of gene expression in breast cancer. However, adjacent non-tumorous tissue represents a suboptimal baseline control because its molecular profile may have been altered, and to some extent, similar to that of tumor. Consequently, important breast cancer-associated DNA methylation may not be identifiable in such comparisons. Using RNA-sequencing data generated from freshly-frozen breast tissue samples, we examined expression of methylation-related genes in 119 breast tumor, 47 adjacent normal-appearing breast tissue samples, and 23 normal breast tissue samples from healthy donors. Bowtie and RESM algorithms were used to align raw reads and quantify transcript abundance. Differential expression analyses were performed using edgeR software and normalized transcript counts. Normal breast tissue from healthy women compared to tumor from cancer patients identified differentially expressed cancer genes that are methylated in tumor, such as BRCA1, ESR1, ESR2, CDKN2A, HIC1, CDCP1, and SFRP1. A subset of these genes were found to be deregulated in adjacent non-tumorous tissue in a similar way as in tumor tissue, including PTGS2, SFN, SYK, FHIT , CST6, GADD45A, and THBS1, and are thus undetectable in the comparison between tumor and adjacent non-tumor tissue. In addition, a set of methylation-related genes were identified only in the comparison between tumor and normal tissue, including genes directly involved in the methylation/epigenetic process (HIST1H4A, KDM1B, MAT2B and SAP18) as well as novel target genes that may be methylated and play an important role in carcinogenesis (NFIA, ARHGAP18, and GRHL2). These findings suggest that normal breast tissue from healthy women is the most desirable control in comparison with tumor tissue to identify novel, tissue-specific methylation changes that may be important for carcinogenesis. Citation Format: Erin Wagner, Wenting Wu, Yunlong Liu, Kenneth Nephew, Jiali Han, Chunyan He. DNA methylation in tumor, adjacent non-tumorous and normal breast tissues. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Sep 24-27, 2015; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2016;76(2 Suppl):Abstract nr A51.
Multistenting during balloon-assisted ERCP using small diameter plastic stents in patients with surgically altered upper gastrointestinal anatomy
Authors: Paul Kröner, Marco D’Assunçao, Klaus Mönkemüller
Journal: Endoscopy (2015)

Balloon-assisted endoscopic retrograde cholangiopancreatography (ERCP) is now commonly used to treat disorders of the pancreatobiliary tract in patients with surgically altered upper gastrointestinal (GI) tract anatomy [1] [2] [3]. However, when either the short or long ERCP scopes have arrived at a tortuous position during the procedure, the ability to deliver accessories such as plastic or metal stents into the biliary tract is limited. Furthermore, the relatively small diameter of the working channel of these scopes limits the possibility of using large stents. In this report, we describe the concept and technique of multistenting using small diameter stents to treat biliary tract strictures.
Elevated Serum Thymosin α<sub>1</sub>Levels Associated with Evidence of Immune Dysregulation in Male Homosexuals with a History of Infectious Diseases or Kaposi's Sarcoma
Authors: E M Hersh, J M Reuben, A Rios, P W Mansell, G R Newell, J E McClure, A L Goldstein
Journal: New England Journal of Medicine (1983)
Dermatoglyphics in the rubella syndrome
Authors: M. Alter
Journal: JAMA (1966)

Epidermal ridges on hands and feet (dermatoglyphics) develop during the first trimester of gestation and remain unchanged thereafter for life. As the rubella virus has a teratogenic effect during this period, it is postulated that an alteration in dermatoglyphics might be present in rubella-damaged individuals. Analysis of dermatoglyphics in 28 rubella-damaged individuals revealed a higher frequency of whorl patterns, a reduced a-b ridge count, a wider atd angle, a tendency towards more patterns on the palm, and a higher frequency of transitional and simian lines than in normals. This study suggests that dermatoglyphics may serve as a marker of a deleterious intrauterine experience during early gestation.
Interim estimates of influenza vaccine effectiveness in 2012/13 from Canada’s sentinel surveillance network, January 2013
Authors: D M Skowronski, N Z Janjua, G De Serres, J A Dickinson, A-L Winter, S M Mahmud, S Sabaiduc, J B Gubbay, H Charest, M Petric, K Fonseca, P Van Caeseele, T L Kwindt, M Krajden, A Eshaghi, Y Li
Journal: Eurosurveillance (2013)

Binary file ES_Abstracts_Final_ECDC.txt matches
LISTER AS A SURGEON
Authors: B. Moynihan
Journal: BMJ (1927)

1865 his attention was directed by a colleague to the work which had been done on fermentation and putrefaction by Pasteur from 1857 onwards.This work came uponi him as a revelation, and almost at once he grasped the full significance of the Frenchman's discoveries for surgery.Ten years later he tells us specifically that the work of Pasteur " long since made me a convert to the germ theory, aild it was on the basis of that theory that I founded the anti- septic treatment of wounds in surgery."Although he frequently reiterated his indebtedness to :Pasteur, it is, I think, a vulgar error to regard Lister as a mere imitator of his great French contemporary.As early as 1861, and before his acquaintance with Pasteur's papers, he was getting near the truth about suppurationi, and afterwards he advanced beyond the point where Pasteur had led him.From now on he became ardent in the pursuit of bacteriology.This was about 1870, when the study of microbes had scarcely emerged