tbuckley/cabot-search huggingface dataset:
PWE-008 Multicentre randomised trial comparing eus guided fine needle aspiration cytology (fnac) with fine needle aspiration biopsy (fna b) in sampling solid pancreatic mass lesions: preliminary results from the procore trial
Authors: J Ortiz-Fernández-Sordo, K Ragunath, M Wireko, M James, P Kaye, K Oppong, M Nayar, A Darne, B Mahon, C Forde, P Tarniere, G Aithal
Journal: Gut (2015)

<h3>Introduction</h3> EUS-guided FNA is the standard of care for tissue sampling of pancreatic lesions. The new Echo Tip ProCore biopsy needle (Cook Medical) was developed to obtain core tissue specimens for histological analysis improving the diagnostic yield and potentially obviating the need for onsite cytopathologist. Our aim was to compare the standard Echo tip ultra FNAC needle with the new Echo Tip Ultra ProCore FNAB needle in the sampling of solid pancreatic lesions. <h3>Method</h3> Randomised multicenter trial (REC Ref 12/EM/0189). All patients referred for EUS-guided tissue sampling of a solid pancreatic mass were invited to participate. Linear EUS (Aloka-Olympus/Hitachi-Pentax) was performed and patients were randomised to either FNAC or FNAB. Due to the nature of the study the endoscopist could not be blinded. A 22G needle was used when sampling from the stomach and a 25G from the duodenum. A maximum of 5 passes were allowed. Sampling time from first insertion of the needle into the lesion to the time the last tissue sample is transferred into the histology pot, number of passes and adequacy for diagnosis were recorded and included for analysis. Immediate and delayed complications were also recorded. <h3>Results</h3> 266 patients were recruited (median age 67 years, 52% men); 142 randomised to the FNAC group and 124 to the FNAB group. Two patients were excluded after randomization; no mass lesion was seen in 1 patient randomised to FNAC and the needle failed in 1 patient in the FNAB group and FNAC was performed. 264 patients were analysed, 141 in the FNAC group (22G=83 and 25G=58. Median max diameter of the lesion 34 mm, range 10–87 mm) and 123 in the FNAB group (22G=53 and 25G=71. Median max diameter 33 mm, range 8–85 mm). There was no statistical significant difference between groups in number of passes (median 4, range 1–5 in the FNAC group vs. median 3, range 1–5 in the FNAB group, p = 0.12), sampling time (median 13 min, range 1–32 min vs. median 13 min, range 2–42 min, p = 0.63) and adequacy of the specimen for diagnosis (90.8% vs. 87%, p = 0.33). Three technical failures were observed in the FNAB group and none in the FNAC cohort (1.6% vs. 0%, p = 0.99). No complications reported in either group. <h3>Conclusion</h3> FNAC and FNAB needles were comparable in terms of sampling time, number of passes, sample adequacy for diagnosis and safety. Technical failure was higher in the FNAB arm but not statistically significant. <h3>Disclosure of interest</h3> None Declared.
ABO blood groups in unipolar and bipolar manic-depressive patients
Authors: R W Shapiro, O J Rafaelsen, L P Ryder, A Svejgaard, H Sorensen
Journal: American Journal of Psychiatry (1977)

The authors determined ABO blood groupings for 66 manic-depressive patients diagnosed and divided into bipolar and unipolar groups according to strict symptomatic and course criteria. A significantly higher percentage of bipolar patients than unipolar patients had blood group O, while a significantly higher percentage of unipolar patients than bipolar patients had blood group A. THese findings provide support for the validity of the unipolar-bipolar distinction and are consistent with the concept that vulnerability to manic-depressive disorders may be related to membrane disturbances.
Atrophy of Rat Testis as Index of Chemical Toxicity
Authors: W E RIBELIN
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
AB0866 Inflammatory Biomarkers and Antibodies to Citrullinated Peptides in Erosive Hand Osteoarthritis
Authors: N. Cid Boza, J.L. Marenco de la Fuente, E. Rejόn Gieb
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Erosive hand osteoarthritis (OA) is characterized by a frequently aggressive inflammatory component that determine a significant aesthetic and functional impact on middle-aged women. Its pathogenesis is still unknown and in recent years is being investigated its relationship with inflammatory arthritis such as rheumatoid arthritis and psoriatic arthropathy. Some studies refer a slight elevation of CRP as an inflammatory marker although the series are small. Knowing the behavior of inflammatory markers, rheumatoid factor and citrullinated peptide can help us understand better the weight of the inflammatory component in this clinical entity and its pathogenesis. <h3>Objectives</h3> To analyze the behavior of serum inflammatory markers, rheumatoid factor (RF) and citrullinated peptide (ACPA) in erosive hand osteoarthritis and to determine the possible relationship with articular inflammatory activity. <h3>Methods</h3> Consecutive patients with erosive hand OA fulfilling theAmerican College of Rheumatology (ACR) criteria, with at least one erosion on hands radiography were included in our study. Clinical presentation form, number of tender and swollen joints, hypertension, diabetes and dyslipidemia were collected. Levels of CRP, ESR, RF, ACPA, total and HDL cholesterol level as well as triglycerides were registered. <h3>Results</h3> A total of 75 patients were included. Attending to clinical presentation there was a 32.5% hands limited, 25.3% with hands and feet involvement and 42.2% polyarthrosis. We found elevated ESR in 8% of patients and PCR in 2.7% at a lower degree in all cases. Three patients presented positive rheumatoid factor (3.8%) all at low titles while 100% were ACPA negative. Number of swollen joints was 1,33+ 1.5 (0.6), and tender joint 3.36 + 3.39 (0 14). With regard to hypercholesterolemia we found 69.6% and hypertriglyceridemia in 24.1% of patients. <h3>Conclusions</h3> In our series the percentage of patients with elevated inflammatory markers was small,as described in previous articles with low values and unrelated with articular inflammatory activity. FR found positive in three patients at low titers and all ACPA negative. This supports the high specificity of ACPA and its usefulness to differentiate early erosive osteoarthritis with proximal predominance of early RA. The high proportion of hypercholesterolemia goes for the described relationship between the metabolic pathway of lipids and osteoarthritis and metabolic syndrome more frequently described in this pathology. <h3>Disclosure of Interest</h3> None declared
Influenza-associated hospitalisations in Finland from 1996 to 2010: unexpected age-specific burden during the influenza A(H1N1)pdm09 pandemic from 2009 to 2010
Authors: A Jacks, J Ollgren, T Ziegler, O Lyytikäinen
Journal: Eurosurveillance (2012)

To assess the burden of influenza on the Finnish healthcare system, we analysed hospitalisations during 1996-2010 using the International Classification of Diseases codes potentially related to influenza and its complications from the national hospital discharge registry. To compare the influenza A(H1N1)pdm09 pandemic with previous influenza seasons in 1996-2009, we calculated hospitalisation rates by age- and diagnostic groups. We built a negative binomial regression model based on times series analysis to assess the impact of the pandemic. Influenza-associated hospitalisation rates were higher during the pandemic compared to pre-pandemic influenza seasons for 5-24 year-olds (incidence rate ratio (IRR): 1.52, 95% confidence interval (CI): 1.44-1.60) and 25-64 year-olds (IRR: 1.33, 95% CI: 1.29-1.36), but did not differ for persons aged ≥ 65 years (IRR: 0.98, 95% CI: 0.97-1.00). Hospitalisation rates exceeded the upper limit of the prediction line by 177% in 5-24 year-olds, 66% in 0-4 year-olds and 57% in 25-64 year-olds. During the influenza season of 2003/04, all age groups had higher-than-expected hospitalisation rates, whereas other seasonal peaks were only notable among persons aged ≥ 65 years. These age-specific differences in the hospital burden underscore the importance of the continuous surveillance of hospitalisations in order to evaluate immunisation priorities for seasonal influenza and pandemic preparedness including use of antiviral medication.
A Multifunctional Theranostic Nanoagent for Dual-Mode Image-Guided HIFU/Chemo- Synergistic Cancer Therapy
Authors: Nan Zhang, Xiaojun Cai, Wei Gao, Ronghui Wang, Chunyan Xu, Yuanzhi Yao, Lan Hao, Danli Sheng, Hangrong Chen, Zhigang Wang, Yuanyi Zheng
Journal: Theranostics (2016)

High-intensity focused ultrasound (HIFU) is deemed to be a promising noninvasive therapeutic modality for cancers as well as non-neoplastic diseases.However, the accuracy of the technique in the diagnosis and treatment of tumors remains unsatisfactory.HIFU, when combined with multifunctional synergistic agents (SAs), has the potential to be of greater diagnostic and therapeutic efficacy.Here we describe a smart and multifunctional hollow mesoporous Prussian blue (HMPBs) theranostic nanoplatform, the hollow structure of which is capable of encapsulating doxorubicin (DOX) and perfluorohexane (HMPBs-DOX/PFH).In vitro and in vivo studies validated that HMPBs-DOX/PFH can be used as an amplifiable dual-mode imaging contrast agent, which can simultaneously enhance ultrasound (US) and photoacoustic (PA) imaging for guiding and monitoring tumor therapy.When exposed to HIFU, this versatile HMPBs-DOX/PFH agent could increase the cavitation effect and use lower HIFU intensity to achieve coagulative necrosis.Furthermore, it significantly accelerated the release of DOX thereby enhancing chemotherapeutic efficacy and avoiding systemic side effects of the drug.Such a novel theranostic nanoplatform is expected to integrate dual-mode guided imaging with greater therapeutic efficacy and fewer side effects and is very promising for the noninvasive synergistic tumor therapy.
Analysis Of Leukemic Stem Cell Population Comparing NPM1wt and NPM1mut AML Patients and Potential Therapeutic Targets
Authors: Vanessa Schneider, Lars Bullinger, Lu Zhang, Markus Rojewski, Markus Wiesneth, Susanne Hofmann, Marlies Goetz, Hubert Schrezenmeier, Ulla Botzenhardt, Thomas F.E. Barth, Konstanze Doehner, Hartmut Doehner, Jochen Greiner
Journal: Blood (2013)
289O The promise of PET/CT-based bone marrow assessment in replacing routine bone marrow biopsy for staging and prognosis of extranodal natural killer/T-cell lymphoma
Authors: W. Yiqin, C. Jiang, X. Li, T. Rong, D. Yaotiao, Z. Wenyan, Z. Liqun, L. Feng, Z. Hong, Z. Hongyu, L. Jie, Z. Sha, D. Wenshuang, L. Weiping, J. Ming
Journal: Annals of Oncology (2015)
AB0745 Clinical and Radiological Progression in Spondyloarthrities Tunisian Patients with Hip Involvement
Authors: I. Mahmoud, K. Maatallah, S. Belghani, O. Saidane, K. Ben Abdelghani, L. Metoui, W. Hamdi, R. Tekaya, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Hip involvement is a severe prognostic factor and may lead to a worse functional outcome. <h3>Objectives</h3> To assess clinical and radiological progression in patient with hip involvement and to assess the impact of TNF inhibitors treatment in this population with severe prognostic factor. <h3>Methods</h3> Axial Spondyloarthritis (AS) patients (satisfying ASAS criteria 2009) with hip involvement with at least two sets of Antero-posterior X-rays of the pelvis at a minimum gap of 2 years were included. Demographic, clinical, radiographic, and laboratory data were collected and analyzed. Radiographic severity was assessed by the modified Stokes Ankylosing Spondylitis Spine Score (mSASSS) and BASRI (Bath Ankylosing Spondylitis Radiologic Index). <h3>Results</h3> 84 patients were evaluated, the median age of onset of the disease was 25 years [16-54ans], HLA B27 was positive in 50% of cases. Forty six patients received TNF inhibitors (infliximab 48%, Adalimumab 14% and Etanercept 36%), 27 patients received csDMARDs and 46 NSAID. Sixty four patients had bilateral hip involvement. At baseline: the median BASDAI and BASFI scores were respectively 5,4 and 5,5. The average ESR and CRP were respectively 47 and 33. The average BASRI spine was 3, the median BASRI hip was 2 and the median mSASSS was 15. At 2years: The median BASDAI and BASFI scores were respectively 3,4 and 3,6. The average ESR and CRP were respectively 34 and 15. the average BASRI spine was 3,7, the median BASRI hip was 2 the median mSASSS was 19. After an average of 5years: The median BASDAI and BASFI scores were respectively 2,9 and 3,8. The average ESR and CRP were respectively 32 and 20. When we compared TNF inhibitors patients versus TNF naïf, there were no significant difference in age of onset, HLA B27, ESR, CRP, BASRI and mSASSS at baseline between the two groups, however TNF inhibitors patients had a higher BASDAI and BASFI scores. At 2 years: TNF inhibitors patients had a significantly lesser BASDAI and BASFI scores. At an average of 5years: TNF inhibitors patients had significantly lesser BASDAI, BASFI and BASRI hip scores. TNF inhibitors have a protective effect on radiographic hip progression OR 5.07 [IC1.86-13.8] <h3>Conclusions</h3> Contrary to what has been reported in several studies on the effectiveness of TNF inhibitors on radiological spine progression, this has not been proved in our study, however TNF inhibitors patients showed a less trend for radiological hip progression. <h3>Disclosure of Interest</h3> None declared
THE PRESENT STATUS OF CANCER RESEARCH.
Authors: S P REIMANN
Journal: JAMA (1907)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
False-positive F-18 FDG gamma camera positron emission tomographic imaging resulting from inflammation of an anterior mediastinal mass in a patient with non-Hodgkin's lymphoma.
Authors: S N Yoon, C H Park, M K Kim, K H Hwang, S Kim
Journal: Clinical Nuclear Medicine (2001)

NAM YOON, SEOK M.D.,*; PARK, CHAN H. M.D.,*; KIM, MOON-KYU M.D.,†; HWANG, KYUNG-HOON M.D.*; KIM, SUZY M.D..* Author Information
AB0135 Aerobic Exercise in Inclined Treadmill Reduce Fatigue in Collagen-Induced Arthritis
Authors: P.V.G. Alabarse, V.D.O.N. Teixeira, J.M.D.S. Silva, R.C.D.E. Santo, E.C. Freitas, P.S. Lora, L.I. Filippin, R.M. Xavier
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Rheumatoid arthritis (RA) patients suffer from joint pain and decreased physical capacity, like muscle wasting and fatigue. Fatigue is a clinical manifestation reported by 40-80% of patients with RA and is regarded as an important feature of the disease. Aerobic exercise may be beneficial for treating this feature in RA patients, however the mechanisms involved are still unclear. <h3>Objectives</h3> To evaluate the effect of aerobic exercise training on the endurance exercise performance in collagen-induced arthritis (CIA) mice. <h3>Methods</h3> Male DBA1/J mice with CIA [1] were randomly divided into 3 groups: wildtype with exercise (WT-EXE, n=4), CIA exercised (CIA-EXE, n=5) and CIA non-exercised (CIA, n=4). Endurance exercise performance test (fatigue) was analyzed in all groups prior to booster injection and each 15 days after protocol started. Eighteen days after the disease induction (booster), WT and CIA-EXE were submitted to training on an inclined treadmill (θ=5°), 45 minutes a day, 5 days per week for 6 weeks at 60% of their own endurance exercise performance. Variables analyzed were disease score, hindpaw nociception, body weight (g), fatigue (by endurance exercise performance in min) and relative muscle weight (muscle weight in mg divided by total animal weight in g). Data was analyzed with ANOVA Two-Way followed by Bonferroni and independent sample t-test and p&lt;0.05 was considered significant. All data are represented as Mean ± SEM. <h3>Results</h3> Body weight was significantly higher in WT-EXE compared with CIA after 4 and 6 weeks of exercise. At week 6 of exercise, CIA-EXE had higher body weight than CIA. Fatigue test at 4 and 6 weeks of experiment was significantly different among all experimental groups; WT-EXE and CIA had, respectively, the highest and the lowest fatigue velocity. Gastrocnemius muscle weight was significantly heavier in control group than in CIA-EXE and CIA. Nociception and clinical score of arthritis did not differ between CIA-EXE and CIA. <h3>Conclusions</h3> Inclined aerobic exercise appears as an interesting intervention in RA to treat decreased physical capacity. Collagen-induced arthritis animals demonstrated decreased endurance, and consequently increased fatigue, characteristics of a good animal model to study fatigue. The exercise protocol used in this study was able to improve this feature, demonstrating that interventions used to treat physical disabilities in RA are also valid in this model. Further studies are necessary to clarify the mechanisms behind fatigue, especially when combining exercise training and common treatments of RA. <h3>References</h3> Rosloniec EF, et al. Curr Protoc Immunol 2010; Chapter 15: Unit 15.5.1-25. <h3>Acknowledgements</h3> Financial support: CAPES, CNPq, FAPERGS, FIPE-HCPA. <h3>Disclosure of Interest</h3> None declared
Max(a), a new low-frequency platelet-specific antigen localized on glycoprotein IIb, is associated with neonatal alloimmune thrombocytopenia
Authors: P Noris, S Simsek, LG de Bruijne-Admiraal, L Porcelijn, E Huiskes, GJ van der Vlist, EF van Leeuwen, CE van der Schoot, AE von dem Borne
Journal: Blood (1995)
AB1103 Cumulative Rate and Factors Associated with Self-Reported Work Disability Among Patients with Systemic Lupus Erythematosus: Data from the Province of Cordoba, Argentina
Authors: M.J. Lόpez Pérez, A. Bertoli, P. Alba, A. Albiero, E. Albiero, D. Alessio, A. Albarelos, P. Asbert, P. Astesana, M. Audisio, N. Benzaquén, M.S. Castaños Menescardi, M. Colazo, L. Encinas, M.J. Haye Salinas, C. Maldini, A. Maldoado, M.J. Morales, L. Onetti, V. Saurit, V. Savio, M. Werner, C. Gobbi
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> SLE can inflict significant morbidity that is reflected not only in the patients9 overall clinical status but also in their ability to work. <h3>Objectives</h3> To examine the cumulative rate and factors associated with work disability in SLE patients in the Province of Cόrdoba, Argentina <h3>Methods</h3> We studied 225 patients, age &gt;16 years. Work disability was defined by patients9 self-report of not working because of their health status. The cumulative rate of work disability was estimated with the Kaplan-Meier method. The relationship between socioeconomic-demographic, self-reported QoL (Lupus PRO) and clinical data [clinical manifestations, diagnostic criteria (1987 ACR criteria), disease activity (SELENA-SLEDAI), damage (SLICC Damage Index), co-morbidities (Charlson Index)] and work disability was examined with Chi-Square and Mann-Whitney U test. Variables with p≤0.10 in these analyses were then examined by multivariable logistic regression with work disability as the dependent variable <h3>Results</h3> Patients were predominantly females (89%) and they had a median (IQR) age at diagnosis of 26.0 (16.0) years. Median disease duration was 96.0 (144.0) months. Fifty-five (24%) patients were work-disabled. The cumulative rate (SE) of work disability was 5% at one year, 25% at five years and 40% at 10 years. In the multivariable analysis, a lower socio-economic status (OR=1.744, 95%CI 1.063-2.861; p=0.028) and a lower QoL of life (OR=0.947, 95%CI 0.910-0,985; p=0.07) were associated with work disability <h3>Conclusions</h3> The cumulative rate of self-reported work disability is high among this sample of SLE patients, reaching 40% at 10 years. None of the variables related to the disease manifestations or its severity were associated with work disability. Patients of lower socio-economic status and lower self reported QoL are at higher risk of becoming work disabled. The latter would imply that any pro-active intervention directed towards preventing work disability among SLE patients in this population should have a broader approach than the disease itself <h3>Disclosure of Interest</h3> None declared
Predictive phenotyping of inherited ichthyosis by next‐generation <scp>DNA</scp> sequencing
Authors: R. Saito, A. Boyce, C.‐K. Hsu, E. Rashidghamat, M. Hide, E.K. Wedgeworth, C. Flohr, J.E. Mellerio, J.A. McGrath
Journal: British Journal of Dermatology (2016)

Advances in DNA sequencing technologies have had a major impact on disease gene discovery strategies, including for many genodermatoses.1 Notably, for inherited forms of ichthyosis, whole exome sequencing (WES) has been used to identify new genes contributing to genetically heterogeneous phenotypes such as autosomal recessive congenital ichthyosis.2,3

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Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy
Authors: Volker Straub, Pavel Balabanov, Kate Bushby, Monica Ensini, Nathalie Goemans, Annamaria De Luca, Alejandra Pereda, Robert Hemmings, Giles Campion, Edward Kaye, Virginia Arechavala-Gomeza, Aurelie Goyenvalle, Erik Niks, Olav Veldhuizen, Pat Furlong, Violeta Stoyanova-Beninska, Matthew J Wood, Alex Johnson, Eugenio Mercuri, Francesco Muntoni, Bruno Sepodes, Manuel Haas, Elizabeth Vroom, Annemieke Aartsma-Rus
Journal: The Lancet Neurology (2016)