Hypervitaminosis A
Authors: MANFRED D. MUENTER
Journal: Annals of Internal Medicine (1974)

Editorials1 January 1974Hypervitaminosis AMANFRED D. MUENTER, M.D.MANFRED D. MUENTER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-105 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe paper by Frame and his associates in this issue about effects of hypervitaminosis A is the most recent of numerous reports on this problem. In 1857 Kane (1), American explorer of the Arctic, described the occurrence of symptoms of acute vitamin A intoxication after ingestion of polar bear liver. Chronic hypervitaminosis A is a well-recognized condition in children (2) and adults (3). The intake of vitamin A in the three patients reported by Frame and his associates was sufficient to cause the clinical picture of hypervitaminosis A; however, all three patients also had been taking vitamin D, admittedly in...References1. KANE E: Arctic Explorations, vol. 1. Hartford, Connecticut, American Publishing Company, 1857, pp. 392-393. Reprinted by the Arno Press, New York, and The New York Times, 1971 Google Scholar2. KNUDSON A and ROTHMAN P: Hypervitaminosis A: a review with a discussion of vitamin A. Am J Dis Child 85: 316-334, 1953 Google Scholar3. MUENTER M, PERRY H, and LUDWIG J: Chronic vitamin A intoxication in adults: hepatic, neurologic and dermatologic complications. Am J Med 50:129-136, 1971 CrossrefMedlineGoogle Scholar4. : Status of vitamin A and vitamin D. Fed Register 38:20723-20725, 1973 Google Scholar5. KATZ C and TZAGOURNIS M: Chronic adult hypervitaminosis A with hypercalcemia. Metabolism 21:1171-1176, 1972 CrossrefMedlineGoogle Scholar6. DI BENEDETTO R: Chronic hypervitaminosis A in an adult. JAMA 201:700-702, 1967 CrossrefMedlineGoogle Scholar7. GERBER A, RAAB A, and SOBEL A: Vitamin A poisoning in adults: with description of a case. Am J Med 16:729-745, 1954 CrossrefMedlineGoogle Scholar8. COHLAN S: Excessive intake of vitamin A as a cause of congenital anomalies in the rat. Science 117:535-536, 1953 CrossrefMedlineGoogle Scholar9. COLLAZO J, TORRES I, and SANCHEZ-RODRIGUEZ : Das A-vitamin und der Cholesterinstoff-Wechsel. Klin Wochenschr 13:1678-1682, 1934 CrossrefGoogle Scholar10. LANGMAN J and WELCH G: Excess vitamin A and development of the cerebral cortex. J Comp Neurol 131:15-25, 1967 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: MANFRED D. MUENTER, M.D.Affiliations: Mayo Clinic and Mayo Foundation Rochester, Minnesota PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited bySafety and Toxicity of Vitamin A Supplements in PregnancyAdverse Effects of Drugs on the LiverDermatologic drugs in pregnancyVitamins E and APseudotumor Cerebri: Some Neuro-Ophthalmologic PerspectivesNutritional and Pharmaceutical Aspects of Calcium SupplementationVitamin Excess and ToxicityVitamin status in treated patients with cystic fibrosis.Nutritional concerns in the alcoholicDrug-Induced Chronic Hepatic DiseaseToxic Effects of Megadoses of Fat-Soluble Vitamins 1 January 1974Volume 80, Issue 1 Page: 105-106 Keywords Children Ingestion Intoxication Liver Vitamin A Vitamin D ePublished: 1 December 2008 Issue Published: 1 January 1974 PDF downloadLoading ...