tbuckley/cabot-search huggingface dataset:
Optimal Mastectomy Timing
Authors: W. L. McGuire, S. Hilsenbeck, G. M. Clark
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Optimal Mastectomy Timing Get access William L. McGuire, William L. McGuire * University of Texas Health Science Center, Division of Medical OncologySan Antonio, Tex. *Correspondence to : William L. McGuire, M. D., University of Texas Health Science Center, 7703 Floyd Curl Dr., San Antonio, TX 78284–7884. Search for other works by this author on: Oxford Academic PubMed Google Scholar Susan Hilsenbeck, Susan Hilsenbeck University of Texas Health Science Center, Division of Medical OncologySan Antonio, Tex. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gary M. Clark Gary M. Clark University of Texas Health Science Center, Division of Medical OncologySan Antonio, Tex. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 5, 4 March 1992, Pages 346–348, https://doi.org/10.1093/jnci/84.5.346 Published: 04 March 1992 Article history Received: 15 November 1991 Accepted: 03 December 1991 Published: 04 March 1992
Dendritic cell–derived exosomes for cancer therapy
Authors: Jonathan M. Pitt, Fabrice André, Sebastian Amigorena, Jean-Charles Soria, Alexander Eggermont, Guido Kroemer, Laurence Zitvogel
Journal: Journal of Clinical Investigation (2016)

DC-derived exosomes (Dex) are nanometer-sized membrane vesicles that are secreted by the sentinel antigen-presenting cells of the immune system: DCs. Like DCs, the molecular composition of Dex includes surface expression of functional MHC-peptide complexes, costimulatory molecules, and other components that interact with immune cells. Dex have the potential to facilitate immune cell-dependent tumor rejection and have distinct advantages over cell-based immunotherapies involving DCs. Accordingly, Dex-based phase I and II clinical trials have been conducted in advanced malignancies, showing the feasibility and safety of the approach, as well as the propensity of these nanovesicles to mediate T and NK cell-based immune responses in patients. This Review will evaluate the interactions of Dex with immune cells, their clinical progress, and the future of Dex immunotherapy for cancer.
EFFECT OF ATORVASTATIN THERAPY ON MACROPHAGES ACCUMULATION IN CORONARY ATHEROSCLEROTIC PLAQUES AS ASSESSED BY OPTICAL COHERENCE TOMOGRAPHY
Authors: Tsuyoshi Nishiguchi, Takashi Kubo, Kenichi Komukai, Yasutsugu Shiono, Makoto Orii, Takashi Yamano, Yoshiki Matsuo, Yasushi Ino, Tomoyuki Yamaguchi, Hironori Kitabata, Kumiko Hirata, Atsushi Tanaka, Takashi Akasaka
Journal: Journal of the American College of Cardiology (2015)
O6.06 * PERIPHERAL T CELL RESPONSES IN GLIOBLASTOMA PATIENTS ARE ASSOCIATED WITH AN IMPROVED SURVIVAL
Authors: C. C. Herold-Mende, J. Mossemann, C. Jungk, R. Ahmadi, A. Unterberg, D. Capper, A. vonDeimling, P. Beckhove
Journal: Neuro-Oncology (2014)

BACKGROUND: Spontaneous anti-tumor T cell responses have been detected in several tumor types. However, not only in glioblastoma it is unclear if such immune responses influence patient outcome. MATERIAL AND METHODS: To detect such immune responses, occurence and frequencies of memory T-cells were determined in the peripheral blood of GBM patients applying the IFN gamma ELISPOT assay and using corresponding tumor lysates (n = 106) or a set of immunogenic polypeptides (n = 32). Extent of resection was assessed by either intraoperative or early postoperative MRI. In addition, intratumoral infiltration of different T-cell subpopulations at the time of first diagnosis was analyzed by immunohistochemistry (n = 20) and compared to the occurrence of spontaneous immune responses. RESULTS: T-cell responses against autologous tumor lysate were detected in 61/106 patients. Subsequent survival analysis concentrating on IDH1wt glioblastoma revealed a significant difference towards an improved survival for patients with a spontaneous immune response (p = 0.0251). Most interestingly, when stratifying for the extent of surgery those patients, who received a complete tumor resection and showed a spontaneous T cell response, survived significantly longer (p = 0.0002). In contrast, in subtotally resected patients the immune response did not improve survival. In line with these observations, occurrence of memory T cell responses against a set of known GBM-associated antigens (TTR, MAGE A3, S100A9) also trended to a better survival in those GBM patients who responded to all three antigens. Finally, increased frequency of intratumoral T cell infiltrates was also associated with the occurrence of spontaneous immune responses and an improved survival. CONCLUSIONS: The present analysis for the first time depicts on several levels a significant influence of the patient's immune system on the course of the disease in GBM patients. In this regard the most crucial prerequisite seems to be the MRI-based complete tumor resection. Most likely surgical removal of the immunosuppressive tumor environment allows for the beneficial reactivation of pre-existing immune responses.
Features of Hepatic Cavernous Hemangioma on Planar and SPECT Tc-99m-Labeled Red Blood Cell Scintigraphy
Authors: M el-Desouki, M Mohamadiyeh, R al-Rashed, S Othman, I al-Mofleh
Journal: Clinical Nuclear Medicine (1999)

To determine the value and diagnostic accuracy of planar and SPECT Tc-99m-labeled red blood cell (Tc-99m RBC) scintigraphy in the investigation of suspected hepatic cavernous hemangioma as found on ultrasound.One hundred patients, 89 women (89%) and 11 men (11%), between 22 and 67 years old (mean age, 38 years) were evaluated for liver masses found on abdominal ultrasound. All the patients had previous Tc-99m RBC scintigraphy. The size of the lesions ranged from 1 to 9 cm. The final diagnosis was reached through cytologic biopsy, or histopathologic tests (or all of these).One hundred thirty lesions were found. With regard to the distribution of the lesions, 116 (89%) were single; 14 (3%) were multiple, with 118 (91%) in the right lobe and 12 (9%) in the left lobe; 83 (64%) were posterior; and 47 (36%) were anterior. With respect to the pattern of radioactivity fill-in, 86 (66%) lesions were typical and 44 (34%) were atypical. The results of Tc-99m RBC scintigraphy showed sensitivity, specificity, and positive and negative predictive and accuracy values of 97%, 83%, 98%, 77%, and 96% respectively. The use of SPECT improved the sensitivity value by 11% for lesions of 1 to 2 cm.Tc-99m RBC scintigraphy is the noninvasive technique most helpful in the diagnosis of hepatic hemangioma, especially in those at risk for lesion rupture or bleeding. SPECT should be performed whenever planar imaging fails to show the lesion by 2 hours. The use of ultrasound should precede scintigraphy for two important reasons: the size and the location of the lesion. Location of the lesion (anterior or posterior) is important for optimal gamma camera acquisition parameters. Lesions less than 1 cm are cannot be detected because they are beyond the limit of spatial resolution of the gamma camera we used.
Tc-99m MAA Total-Body Imaging to Detect Intrapulmonary Right-to-Left Shunts and to Evaluate the Therapeutic Effect in Pulmonary Arteriovenous Shunts
Authors: GANG LU, WEI-JEN SHIH, CHIEN CHOU, JING-YING XU
Journal: Clinical Nuclear Medicine (1996)

The appearance of radiotracer in the systemic circulation to document the visualization of the brain, kidneys, and spleen after intravenous administration of Tc-99m MAA indicates right-to-left shunts because MAA particles (20-60 μm) are supposedly trapped in the pulmonary bed (less than 15 μm). Six hypoxemia patients (1 male, 5 females; age range, 12-52 years) with intrapulmonary right-to-left shunts were evaluated by Tc-99m MAA dynamic perfusion imaging and total-body scans. Tc-99m MAA total-body imaging of the six patients with intrapulmonary right-to-left shunts (3 patients with chronic liver disease/cirrhosis of the liver and 3 patients with pulmonary arteriovenous fistulae) revealed significant radiotracer uptake in extrapulmonary organs such as the brain, kidneys, and spleen; a shunt ratio, estimated by a semiquantitative method, ranged from 17.8% to 52%. All dynamic pulmonary perfusion scans showed a normal sequence of cardiopulmonary flow without intracardiac shunts. Three patients with pulmonary arteriovenous fistulae underwent a second Tc-99m MAA total-body imaging after embolization therapy (2 patients) or lobectomy (1 patient). The results in lobectomized patients were negative for uptake in extrapulmonary organs; the two patients who underwent embolization therapy demonstrated only mild improvement. As a consequence of these findings, the authors conclude that Tc-99m MAA total-body imaging can be used for the diagnosis of intrapulmonary right-to-left shunts, as well as for the evaluation of postshunt therapy.
Concern Grows Over Prostate Cancer Treatment Options
Authors: T. Parkins
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Concern Grows Over Prostate Cancer Treatment Options Get access Troy Parkins Troy Parkins Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 12, 15 June 1994, Pages 897–898, https://doi.org/10.1093/jnci/86.12.897 Published: 15 June 1994
Etude de survie et d'efficacité de la fermeture gastrique par T-Tag endoscopiques après cholécystectomie transgastrique (NOTES) chez l'animal
Authors: H Perrin, JF Demarquay, R Dumas, C Ferrari
Journal: Endoscopy (2012)

Ce travail a pour but d'évaluer la faisabilité et l'efficacité de la fermeture endoscopique gastrique après cholécystectomie transgastrique chez le porc.
Doctors Lack Training in Hospice Care
Authors: Karen Vaucrosson
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Doctors Lack Training in Hospice Care Get access Karen Vaucrosson Karen Vaucrosson Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 15, 5 August 1992, Pages 1153–1154, https://doi.org/10.1093/jnci/84.15.1153-a Published: 05 August 1992
IMPLANTACIÓN DE UN PROGRAMA DE SEDACIÓN PROFUNDA POR ENDOSCOPISTAS E INFLUENCIA DE LA CURVA DE APRENDIZAJE EN LAS COMPLICACIONES OBSERVADAS
Authors: F Alberca De Las Parras
Journal: Endoscopy (2013)

Introducción: La sedación profunda se está imponiendo por seguridad, accesibilidad, universalidad y autonomía. Comenzamos con agendas específicas (fase inicial: 2 médicos-1enfermero); tras 10 m. se pasó al sistema médico-enfermero (fase estabilización), todos con cursos de capacitación SEED). Objetivo: Comprobar si existían cambios en las complicaciones registradas al analizar por fases. Material y Método: Análisis retrospectivo de los registros prospectivos (febrero 2012 – mayo 2013) detectando tiempos, dosis, complicaciones y características de los pacientes. Resultados: Se realizaron 471 procedimientos (343C, 101G, 16G +C, 8USE). Se eliminaron 22 (datos insuficientes). La mayoría eran ASA 1 – 2 (criterio inicial) y el rango de edad fue muy amplio. Las complicaciones detectadas fueron: 12 desaturaciones leves (< 95%), 4 desaturaciones graves (< 85%), 1 hipotensión, 18 bradicardias (< 50 ppm). Todos se solucionaron conservadoramente. No existió relación entre ASA y complicaciones, ni tampoco al analizar entre rangos de edad. En la 1afase se detectaron 8 bradicardias y 10 en la 2a. Ocurrieron en 3 de 16G+C (18,75%) y en 15 de 346C (4,27%). 8 desaturaciones leves 8 en 1afase y 4 en 2a, y en las graves, 3 y 1 respectivamente. Se relacionaba este aumento inicial con una mayor dosis y un mayor tiempo de exploración.
Increased Vascular Reactivity in Experimental Hypertension
Authors: DAVID B. GORDON, ALFREDO NOGUEIRA
Journal: Circulation Research (1962)

The responsiveness to norepinephrine of aortic strips from hypertensive rats and from normotensive rats was compared. The strips were set up in a bath of Krebs-Ringer solution, and isometric tension development upon addition of norepinephrine was recorded. The hypertensive strips produced the greatest tension, indicating a greater reactivity to norepinephrine. It was found that the initial tension exerted upon the strip greatly influenced its response, there being an optimal initial tension at which the greatest active response was obtained. These results support the hypothesis that hypertension may be due to an excessive reactivity of vascular smooth muscle.
Abstract 4296: High rates of esthesioneuroblastoma in adenomatous polyposis coli (apc) mutant zebrafish suggest a new modifier mutation altering tissue specificity of Wnt/β-catenin-dependent hyperproliferation.
Authors: Vivianne E. Greenwood, Noah Museles, Quinn Weinberg, Eric Glasgow
Journal: Cancer Research (2013)

Abstract The most common mutation in human colon cancer is inactivation of adenomatous polyposis coli (APC), a key inhibitor of the Wnt/β-catenin pathway. If left untreated, all humans carrying germline APC-inactivating mutations will develop colon cancer by the age of forty. In addition, truncation of APC is the primary contributor to sporadic colon cancer in humans. In zebrafish, the same truncated mutation in apc also causes digestive tract neoplasia. However, the incidence of tumors outside the intestinal system in the apc mutant zebrafish has not been reported. To determine if other tumors arise at high frequencies in the apc mutant, we monitored several cohorts of zebrafish derived from apc(hu147/+) incrosses on a weekly basis over a one-year period, covering the age of 6 to 18 months post-fertilization. Specimens displaying evidence of tumors or general signs of declining health were euthanized, photographed, tail-clipped for genotypic analysis, and then fixed and embedded in paraffin for histological examination. Analysis of the data showed that 1.2% of the apc(hu147/+) zebrafish had abnormally distended abdomens (possibly from intestinal neoplasia), and 1.8% of the mutants developed olfactory neuroblastoma (esthesioneuroblastoma). We have yet to detect a single wild-type fish with esthesioneuroblastoma in these cohorts. Overall, the results indicate that our apc(hu147/+) zebrafish exhibit a remarkably increased incidence of esthesioneuroblastoma compared to wild-type fish or other tumor-prone mutants. Furthermore, relative to the latter, our apc(hu147/+) zebrafish begin developing tumors of any type at an earlier age. Histopathological examination showed these esthesioneuroblastoma tumors to be highly invasive. No previous reports indicate that ethesioneuroblastoma is a common tumor type in apc(hu147/+) zebrafish. Therefore, we propose to have discovered a new modifier mutation, which leads to hyperproliferation of olfactory neuroepithelium in response to dysregulation of the Wnt/β-catenin pathway. Identification of this mutant gene is expected to shed light on interactions of tissue-specific regulators with components of the Wnt/β-catenin signaling pathway to control rates of cell proliferation and differentiation. Citation Format: Vivianne E. Greenwood, Noah Museles, Quinn Weinberg, Eric Glasgow. High rates of esthesioneuroblastoma in adenomatous polyposis coli (apc) mutant zebrafish suggest a new modifier mutation altering tissue specificity of Wnt/β-catenin-dependent hyperproliferation. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 4296. doi:10.1158/1538-7445.AM2013-4296
Smoking With the Enemy: Tobacco Council Funds Scientists
Authors: N. Volkers
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Smoking With the Enemy: Tobacco Council Funds Scientists Get access Nancy Volkers Nancy Volkers Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 18, 18 September 1991, Page 1287, https://doi.org/10.1093/jnci/83.18.1287 Published: 18 September 1991
Abstract 1889: <i>Helicobacter pylori</i> seropositivity and risk of lung cancer
Authors: Jill Koshiol, Roberto Flores, Tram Lam, Philip R. Taylor, Stephanie Weinstein, Jarmo Virtamo, Demetrius Albanes, Guillermo Perez-Perez, Neil E. Caporaso, Martin J. Blaser
Journal: Cancer Research (2011)

Abstract BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide. Infections may contribute to lung carcinogenesis. Results from a few small studies have suggested that Helicobacter pylori (HP) may be a potential risk factor. However, these studies have been limited in size and in the evaluation of lung cancer histology and smoking. METHODS: We conducted a study of 350 lung adenocarcinoma cases, 350 squamous cell carcinoma cases, and 700 controls nested within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study (ATBC) cohort of male Finnish smokers. Controls were 1 to 1 matched by age (+/- 5 years) at and date (+/- 30 days) of baseline serum draw and had to be alive and cancer free at the date that the corresponding case was diagnosed. We used enzyme linked immunosorbent assays to detect immunoglobulin G antibodies against HP whole-cell and CagA antigens and calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) for associations between HP seropositivity and lung cancer risk using conditional logistic regression. RESULTS: 79% of cases and 78% of controls were seropositive for whole cell HP, and 43% of cases and 44% of controls were seropositive for the cytotoxin-associated gene (cagA) antigen. Whole cell seropositivity was not associated with lung adenocarcinoma (OR: 1.2, 95% CI: 0.80-1.8) or squamous cell carcinoma (OR: 1.1, 95% CI: 0.73-1.6) after adjusting for age at serum draw, date of serum draw, age at smoking initiation, pack-years, and cigarettes smoked per day. Similarly, CagA seropositivity was not associated with lung adenocarcinoma (OR: 1.1, 95% CI: 0.78-1.5) or squamous cell carcinoma (OR: 0.88, 95% CI: 0.63-1.2). CONCLUSIONS: Despite earlier small studies suggesting that HP may contribute to lung carcinogenesis, HP seropositivity does not appear to be associated with lung cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1889. doi:10.1158/1538-7445.AM2011-1889
Reorganisation at Global Fund sparks $1.6bn in new donations
Authors: A. Gulland
Journal: BMJ (2012)

Charities have urged the Global Fund to Fight Aids, Tuberculosis and Malaria to kick start its funding programme after it announced that it has more than $1.6bn (£1bn; €1.2bn) in extra money.

In November the fund said it was suspending funding for new projects until 2014 because of a shortfall in donations.1 But on 9 May it announced that a new financial forecast showed that in 2012-14 it would have more than $1.6bn in additional funding on top of the $616m it is currently spending on existing programmes.

Gabriel Jaramillo, the fund’s newly appointed general manager, said that the forecast was better …
AB0433 The association of serum adiponectin levels with insulin resistance and inflammatory parameters in patients with rheumatoid arthritis
Authors: S. Yasar Bilge, N. Kasifoglu, T. Kasifoglu, E. Gonullu, C. Korkmaz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Rheumatoid Arthritis (RA) is a chronic, inflammatory, autoimmune disease (1). Adiponectin is an adipocytokin which has anti-atherogenic, anti-angiogenic, anti-inflammatory and anti-tumor effects (2). Adiponectin also increases the sensitivity to insulin (3). <h3>Objectives</h3> The aim of this study was to investigate the relationship between disease activity, acute phase response, insulin resistance and adiponectin levels, known to have antiinflammatory effects in RA. <h3>Methods</h3> Sixty-five patients with RA and thirty patients with osteoarthritis (OA) who fulfilled the American College of Rheumatology (ACR) classification criteria for each disease were included for this study. Patients who have a previous history of diabetes mellitus or recieving oral anti-diabetic agents, insulin, anti-obesity drugs or disease modifying anti-rheumatismal drugs were excluded. Body mass index, acute phase reactants, DAS-28, fasting blood glucose, insulin levels and adiponectin levels were measured at the beginning (0. month) and 3th month of the therapy in RA patients. <h3>Results</h3> Adiponectin levels at the third month of the therapy were significantly increased compared with baseline levels. However there was no correlation between adiponectin levels and disease activity or acute phase reactans in both baseline and third month of the therapy. Acute phase response and DAS-28 decreased at the end of the 3rd month, as expected. The decrease in insulin resistance was statistically non-significant.There was no correlation between adiponectin levels and insulin resistance at the begining of the therapy but there was an inverse correlation at the end of 3rd month. <h3>Conclusions</h3> We believe that the cause of elevation in adiponectin levels and the decrease in insulin resistance are the results of immunsupresive therapy used in treatment of RA. <h3>References</h3> Scott DL, Wolfe F, Huizinga TWJ. Rheumatoid arthritis. Lancet 2010; 376: 1094-1108 Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol 2003; 148:293-300 Kadowaki T, Yamauchi T. Adiponectin ve adiponectin receptors. Endocrine Reviews 2005; 26(3): 439-451 <h3>Disclosure of Interest</h3> None Declared
BOOK REVIEWS: 2nd Review
Authors: M. A. LEVINE
Journal: JNCI Journal of the National Cancer Institute (1992)

BOOK REVIEWS: 2nd Review Get access Breast Diseases, 2nd Edition Jay R. Harris , Samuel Hellman , I. Craig Henderson , David W. Kinne , eds. Philadelphia : J. B. Lippincott , 1991 . 928 pp., illus. $149.50 MARSHALL A. LEVINE MARSHALL A. LEVINE Division of Oncology, Sinai Hospital of BaltimoreBaltimore, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 8, 15 April 1992, Page 640, https://doi.org/10.1093/jnci/84.8.640 Published: 15 April 1992
Postprandial Reduction in Blood Pressure in the Elderly
Authors: Lewis A. Lipsitz, R. Peter Nyquist, Jeanne Y. Wei, John W. Rowe
Journal: New England Journal of Medicine (1983)

We evaluated the effects of a meal on systolic blood pressure and heart rate in elderly institutionalized subjects (mean age +/- S.E.M., 87 +/- 1) with and without histories of syncope and in young normal subjects. Pulse and blood pressure were measured before the test meal and at intervals for up to 60 minutes afterward. By 35 minutes mean systolic blood pressure had declined a maximum of 25 +/- 5 mm Hg in 10 elderly subjects with syncope and 24 +/- 9 mm Hg in 10 elderly subjects without syncope (P less than 0.03); the level then stabilized without further change until 60 minutes. There were no changes in blood pressure in 11 young subjects or in elderly subjects not given a meal. The postprandial change in systolic pressure was not related to medications or diagnoses. Compensatory cardioacceleration was minimal in the elderly, suggesting impaired baroreflexes. Our observations show that postprandial reductions in blood pressure may predispose the elderly to symptomatic hypotension.
An Unanticipated Halo
Authors: ERIC E. TRENKMANN, LIONEL S. ZUCKIER, EUGENE FINE
Journal: Clinical Nuclear Medicine (2001)

From the Departments of Nuclear Medicine* and Radiology,† Jacobi Medical Center, Bronx, New York Received for publication March 7, 2001. Accepted April 11, 2001. Reprint requests: Eugene Fine, Department of Nuclear Medicine, Jacobi Medical Center, BN-21, 1400 Pelham Parkway South at Eastchester Road, Bronx, New York 10461.