tbuckley/cabot-search huggingface dataset:
Studies on Cardiac Functional Murmurs
Authors: Teizo Araki
Journal: Circulation (1964)

The  diseases of the heart and great vessels, e.g. valvular regurgitation and/or stenosis, anomalous shunt between right and left side of the heart and so on, may produce disorder of blood stream and result in turbulance or impact of accerelated blood flow, which cause organic heart  The  is important for diagnosis of these cardiac abnormalities. Functional cardiac murmur is defined as a bruit which is produced only by  exaggeration of blood flow velocity, and never based on any structural cardiovascular anomalies. The differentiation between these two different type of murmur, therefore, is very important and not always easy to achieve. There have been several reports concerning to the differentiation between two types of murmur, some of these include  caused by secondary hypertrophy of crardiac chamber in the category of functional murmur and some are inclined to exclude these type of murmur. So far the pathogenesis of   is persumed to be based on increased blood flow velocity. It is described that   is usually ejection type systolic  arising in the outflow tract of the right ventricle or across pulmonic valve. MACHII has presumed the mechanisrn as eddy current effects right behind the trigonoidation of pulmomic valves. The data obtained by intracardiac phonocardiography and direct surface phonocardiography, which indicate that main pulmonary artery is the point of maximal intensity in all of the cases, strongly suports the above conclusion. GROOM has demonstrated consistent occurrence of ejection type systolic  in all of the healthy materials regard-less sex or age using high gain high frequency phonocardiography in sound proof room. So-called functional murmur s, i therefore, thought to be exaggeration of above mentioned bruit. Hyperthyroidism and anemia have been named as most typical exaggeration. Disappearance or diminution of   in these diseases after improvement of the conditions have been reported. The author has experimentally induced anemia in dogs by exchanging blood with Moriamin-P at a dosis of 20 cc per Kilogram bodyweight within 10 minutes. This procedure was repeated 4 times in succession. All of the animals have presented systolic  at the end of the experiment. Moramin-P has lower viscosity than that of blood. The same experiment using 2.5% gelatin solution, which has same viscosity as blood, instead of Moriamin-P has resulted systolic  in none of the animals. Another attempt to induce experimental hemolytic anemia was made by subcutaneous injection of phenylhydrazin in dosis of 10 mg pro die. 15 days after the first injection, hematocrit level has declined down to 15% and all of the animals have presented systolic anemic murmur. Hematocrit level reached down to its lowest level around 10 days after the first injection, when II-I time shortened to its minimal level, and the maximal intensity of the  and maximal increase in the area of the cardiac silhouette were observed 2 or 3 days later the time of minimal hematocrit.
Abstract P155: Dietary Pattern Improvements are Related to Less Weight Gain During the Transition From Adolescence Into Young Adulthood
Authors: Tian Hu, David R Jacobs, Nicole Larson, Gretchen J Cutler, Melissa N Laska, Dianne Neumark-Sztainer
Journal: Circulation (2016)

Background: Excess weight gain during childhood and adolescence is associated with elevated cardiovascular risk factors in young adulthood. Little is known about dietary pattern in relation to weight gain during early life stages. Objectives: We assessed change in diet quality, using the A Priori Diet Quality Score (APDQS), and its relationship with concurrent weight change among a large, diverse group of adolescents transitioning into young adulthood. Methods: Participants recruited from Minnesota public secondary schools, followed for 10 years, reported on diet and weight status in early adolescence (1999; mean age 15 y), late adolescence (2004; mean age 20 y) and young adulthood (2009; mean age 25 y). We included 1,474 initially non-obese participants with all three surveys. The APDQS was the sum of quintile scores 0 to 4 for the 16 food groups rated as beneficial in terms of hypothesized health effects plus scores in reverse order (4 to 0) for the 9 foods rated as adverse, with 12 food groups rated neutral not adding to the score. The score focused on varied, plant-based, less processed dietary patterns, with contributions from many food groups. A higher score indicates a diet with better quality. Results: Mean (SD) weight increased from 61 (14) kg in 1999 to 76 (19) kg in 2009. Over the same period mean (SD) APDQS increased from 46 (12) to 53 (12). The APDQS stabilized with aging (within-person tracking correlation r=0.50 from late adolescence to young adulthood vs r=0.32 from early to late adolescence). An increase in APDQS was associated with less weight gain, with exception over early to late adolescence (Table). Conclusions: APDQS captures aspects of Mediterrean and prudent diets and is more powerful than individual food items. This cohort study suggests that an increase in diet quality is associated with less weight gain during the transition from adolescence to young adulthood. Furthermore, this diet pattern begins to track as strongly as physical risk factors like blood pressure starting in late adolescence.
Prognositc Factors and Survival in Patients with Hypocellular Myelodysplastic Syndrome: Development of a Disease Specific Prognostic Score.
Authors: Wei-gang Tong, Tapan Kadia, Gautam Borthakur, Elias Jabbour, Sherry Pierce, Jianqin Shan, Jorge Cortes-Franco, Farhad Ravandi, William Wierda, Deborah Thomas, Hagop Kantarjian, Guillermo Garcia-Manero
Journal: Blood (2009)
Дуоденогастральний рефлюкс та його взаємозв’язок з інфекцією Неlicobacter pylori
Authors: A.N. Kovalenko, А.V. Salenko, Yu.S. Breslavets
Journal: GASTROENTEROLOGY (2020)

У статті наведено результати вивчення ступеня обсіменіння слизової оболонки шлунка інфекцією Нelicobacter pylori і її зв’язок з дуоденогастральним рефлюксом. Виявлено пряму залежність між рівнем жовчних кислот у шлунковому соку й наявністю Нelicobacter pylori, що в поєднанні з дуоденогастральним рефлюксом негативно впливає на стан слизової оболонки шлунка.
The Fifth Region of Epidermal Growth Factor like-Domain of Thrombomodulin Is Essential to Produce Cytoprotection
Authors: Takayuki Ikezoe, Jing Yang, Chie Nishioka, Keigo Nakamura, Hiroya Yurimoto, Yasuyoshi Sakai, Goichi Honda, Akihito Yokoyama
Journal: Blood (2014)
Negative Impact of KIR-Ligand Mismatch on Transplant-Related Mortality (TRM) in Umbilical Cord Blood Transplant (UCBT) Recipients.
Authors: Claudio G. Brunstein, John E. Wagner, Daniel J. Weisdorf, Juliet N. Barker, Hariet Noreen, Ye Tan, Martin Maiers, Michael R. Verneris, Bruce R. Blazar, Jeffrey S. Miller
Journal: Blood (2005)
Downregulation of IRS2 in Myelodysplastic Syndrome (MDS) May Be Related to Impaired Cell Differentiation,
Authors: Joao Machado-Neto, Patricia Favaro, Mariana Lazarini, Adriana S S Duarte, Leticia Fröhlich Archangelo, Irene Lorand-Metze, Fernando Ferreira Costa, Sara T Olalla Saad, Fabiola Traina
Journal: Blood (2011)
Pregnancies in Patients with Philadelphia Negative Chronic Myeloproliferative Disorders: Interim Report of the European LeukemiaNet Data Base
Authors: Sabine Struve, Guido Finazzi, Konstanze Doehner, Stefanie Schauer, Eva Lengfelder, Heinz Gisslinger, Tiziano Barbui, Martin Griesshammer
Journal: Blood (2008)
RWTY (R We There Yet): An R package for examining convergence of Bayesian phylogenetic analyses
Authors: Dan L. Warren, Anthony J. Geneva, Robert Lanfear
Journal: Molecular Biology and Evolution (2016)

Bayesian inference using Markov chain Monte Carlo (MCMC) has become one of the primary methods used to infer phylogenies from sequence data. Assessing convergence is a crucial component of these analyses, as it establishes the reliability of the posterior distribution estimates of the tree topology and model parameters sampled from the MCMC. Numerous tests and visualizations have been developed for this purpose, but many of the most popular methods are implemented in ways that make them inconvenient to use for large data sets. RWTY is an R package that implements established and new methods for diagnosing phylogenetic MCMC convergence in a single convenient interface.
Sacubitril/Valsartan (Entresto) for Heart Failure
Journal: JAMA (2015)

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Bortezomib (BOR) and High Dose Melphalan (HDM) as Conditioning Regimen Before Autologous Stem Cell Transplantation (ASCT) for De Novo Multiple Myeloma (MM): Final Results of the IFM Phase II Study VEL/MEL
Authors: Murielle Roussel, Anne Huynh, Philippe Moreau, Jean Luc Harousseau, Cyrille Hulin, Denis Caillot, Christophe Fruchart, Gerald Marit, Brigitte Pegourie, Michel Attal
Journal: Blood (2008)
Altered Gene Expression in CD34+ Cells from PBSC Grafts from Patients Developing t-MDS Following Autologous Transplantation for Lymphoma.
Authors: Liang Li, Xiwei Wu, Jerald P. Radich, Lue Ping Zhao, Liton Francisco, Asako Komiya, Holly Damasco, Stephen J. Forman, Smita Bhatia, Ravi Bhatia
Journal: Blood (2006)
Single Institute Analysis of Reduced Intensity Cord Blood Transplantation from Unrelated Donors for Adults with Advanced Lymphoid Malignancies.
Authors: Atsushi Wake, Naoyuki Uchida, Kazuya Ishiwata, Shinsuke Takagi, Masanori Tsuji, Hisashi Yamamoto, Mayumi Yoshimi, Madoka Narita, Kimiko Sagawa, Hideki Araoka, Daisuke Kato, Naofumi Matsuno, Kazuhiro Masuoka, Akiko Yoneyama, Shigeyoshi Makino, Shuichi Taniguchi
Journal: Blood (2008)
Effective Remission Induction for AML Using Two Days of Chemotherapy: Older Patients Tolerate and Respond Equally Well
Authors: Neel B. Shah, Melissa L. Larson, Nitin Goyal, Ann M. Thomas, Jamile M. Shammo, John J. Maciejewski, Stephanie A. Gregory, Parameswaran Venugopal
Journal: Blood (2008)
MPTH-18STREAMS, VORTICES, AND NEUROSPHERES: IN VIVO NON-RANDOM LARGE SCALE SELF-ORGANIZATION OF GLIOBLASTOMA MULTIFORME AND THE ROLE OF NOVEL HISTOPATHOLOGICAL STRUCTURES
Authors: Pedro Lowenstein, Sebastien Motsch, Carl Koschmann, Felipe Nuñez-Aguilera, Gregory Baker, Alexandra Calinescu, Neha Kamran, Vikek Anand Yadav, Daniel Zamler, Marta Dzaman, Maria Castro
Journal: Neuro-Oncology (2015)

GBM (WHO IV) histological structures used in glioma diagnosis are pseudopalisades, microvascular proliferation, and necrosis. To these we can add Scherer's structures: the perivascular, perineuronal, white matter, and subpial growth of glioma cells. Though CXCL12 is important in the organization of Scherer's structures, the molecular and cellular basis of the other histopathological structures is not fully understood. To determine the large scale organization of gliomas we studied various models, including transplantable gliomas (mouse, human glioma stem cells), and genetically induced gliomas using the Sleeping Beauty Transposase system (NRas, LgT, sh-p53, PDGF, sh-ATRX, IDH1mut). Examination of all glioma models indicates the existence of streams, a hallmark of self-organization. Streams are 10-20 cells across, of various lengths, and distributed throughout the tumors. Within streams cells are fusiform and at the tumor border participate in glioma invasion. Streams can be understood mathematically using models from statistical mechanics. Experimentally, streams facilitated the migration of slower migrating glioma stem cells. We propose that streams accelerate glioma growth; inhibiting stream formation may be beneficial therapeutically. We also detected the presence of vortices in which cells appear as if rotating around a central axis. Vortices were found in murine transplantable models and in genetically induced gliomas -independently of individual genetic mutations-. Vortices can be studied mathematically using the theories of fluid dynamics. We propose that vortices are cores of glioma stem cells that nucleate brain tumor growth around them. Disrupting vortex formation could also lead to novel therapies. Our work demonstrates that gliomas display large scale, non-random, self-organization. We show the existence of novel histopathological structures in glioblastoma, and their potential role in glioma growth and invasion. We are currently working to understand their cellular, molecular, and mathematical basis as this will make them into novel so far unknown therapeutic targets.
Continuous Erythropoietin Receptor Activator Enhances Iron Metabolism by Hepcidin Down-Regulation and Maintains Stable Hemoglobin Levels by Controlling Maturation Rate of Erythroid-Lineage Cells
Authors: Yusuke Sasaki, Mariko Noguchi-Sasaki, Ken Aizawa, Yuki Matsumoto-Omori, Hirotaka Kanada, Keigo Yorozu, Yoshiyuki Moriguchi, Yasushi Shimonaka
Journal: Blood (2011)
Novel Molecular Findings in Protein Tyrosine Phosphatase Receptor Gamma (PTPRG) Among Chronic Myelocytic Leukemia (CML) Patients Studied By Next Generation Sequencing (NGS): A Pilot Study in Patients from the State of Qatar and Italy
Authors: Nader I Al-Dewik, Maria Monne, Mohammed Araby, Ali Al Sayab, Marzia Vezzalini, Luisa Tomasello, Helmout Modjtahedi, Claudio Sorio, Mohamed A. Yassin
Journal: Blood (2016)
Clinical Utility of High-Throughput and Complimentary Genomic Tumor Profiling in Hematologic Malignancies
Authors: Zeqiang Ma, Jason Gottwals, Hao Ho, Kristina J. Fasig, Heather Rietz, Taylor Hartley, Vladimir Kravstov, David C. Spence, Dan Connor, Ron Turnicky, James Prescott, Patrick Lennon, Malini Sathanoori, Ian W. Flinn, Jesus G. Berdeja, William B. Donnellan, Scott Wheeler, Christopher Coldren, Pranil Chandra, Sandeep Mukherjee, Terence Casey
Journal: Blood (2015)
Gbm Heparan-Sulfate Alterations in Experimental Diabetic Nephropathy
Authors: J. van den Born, A.A. van Kraats, M.A.H. Bakker, K.J.M. Assmann, H.B.P.M. Dijkman, J.A.W.M. van der Laak, J.H.M. Berden
Journal: Kidney International (1995)
Updated guidance for writing a British Association of Dermatologists clinical guideline: the adoption of the <scp>GRADE</scp> methodology 2016
Authors: M.F. Mohd Mustapa, L.S. Exton, H.K. Bell, A.D. Ormerod, J.R. Hughes, N.J. Levell, C.H. Smith, P.M. McHenry, K. Gibbon, D.A. Buckley, T.A. Leslie, E.C. Mallon, S. Wakelin, R.Y.P. Hunasehally, M.J. Cork, G.A. Johnston, F.S. Worsnop, J. Natkunarajah, N. Chiang, S. Ungureanu, J. Donnelly, C. Saunders, A.G. Brain
Journal: British Journal of Dermatology (2017)
Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma
Authors: Sophia Gayle, Sean Landrette, Neil Beeharry, Chris Conrad, Marylens Hernandez, Paul Beckett, Shawn M. Ferguson, Talya Mandelkern, Meiling Zheng, Tian Xu, Jonathan Rothberg, Henri Lichenstein
Journal: Blood (2017)
A Very Short Mutational Hot-Spot in the IGH 5′Sμ Region Suggests That the Acquisition of a Class Switch Recombination Defect Is an Important Step Toward Lymphomagenesis.
Authors: Philippe Ruminy, Fabrice Jardin, Dominique Penther, Françoise Parmentier, Gérard Buchonnet, Jean-Michel Picquenot, Hervé Tilly, Christian Bastard
Journal: Blood (2005)
The Virtual Office Visit for Women With Gestational Diabetes Mellitus
Authors: David A. Sacks, Deborah Ling Grant, Mayra Macias, Xia Li, Jean M. Lawrence
Journal: Diabetes Care (2017)

The ability to replicate a prenatal office visit in a more convenient location for the patient (home, office, etc.) has potential advantages, including reducing the need for transportation, childcare, and taking time off from work. After collecting data using anonymous surveys and qualitative interviews to evaluate acceptability (1), we conducted a proof-of-concept study of health care delivery combining patient-operated technologies with telephone encounters, which we called “virtual office visits.”

Ten women with newly diagnosed gestational diabetes mellitus (GDM) were recruited. Inclusion criteria were ages between 18 and 45 years, a singleton pregnancy, gestational age less than 32 weeks upon entry into the study, and having a smartphone. At the study enrollment visit, each participant was given a set of devices consisting of a Bluetooth-enabled portable memory-based glucose meter (FORA GD40 or FORA MD), weight …
Mice Deficient in Urokinase-Type Plasminogen Activator (uPA) or uPA Receptor Develop Significantly Diminished Collagen-Induced Arthritis
Authors: Sherry Thornton, Harini Raghu, Alice Jone, Carolina Cruz, Cheryl L. Rewerts, Malinda D. Frederick, Jay L. Degen, Matthew J. Flick
Journal: Blood (2014)
THU0142 Relation between ntx and carf in rheumatoid arthritis
Authors: M Oh, H Kikuchi, M Saitoh, H Nisisaka, T Matusita, S Sohen
Journal: Annals of the Rheumatic Diseases (2001)

<h3>Background</h3> It is well known that cytokines cause abnormal immunity affecting bone resorption in rheumatoid arthritis (RA). NTx (typeI collagen cross-linked N-telopeptides) is bone resorption marker, CARF (Anti-agalactosyl IgG antibodies) is a new rheumatoid factor which is able to detect all RF isotype, and allows early diagnosis of the onset of RA. <h3>Objectives</h3> To find out the bone resorption in RA, we investigated the relation between NTx and CARF, inflammatory parameters CRP and ESR, Lansbury’s joint count which is the score for the affected joint. <h3>Methods</h3> NTx and CARF were measured in 31 RA patients (male:1 case, female:30 cases). And CRP, ESR, Lansbury’s joint count was measured at the time, and examined about that relationship. <h3>Results</h3> Significant positive correlations were observed between NTx and CARF (r2 = 0.211 p = 0.0093), and between NTx and joint count (r2 = 0.154 p = 0.0321), however, no significant correlations were observed between NTx and CRP or ESR. <h3>Conclusion</h3> These results suggest that NTx has a potentiality as the joint destruction marker, reflecting not only general inflammation but also local inflammation such as arthritis.
Adherence with Injectibal Prophylaxis for Venous Thromboembolism (VTE) Following Total Hip (THR) and Total Knee (TKR) Replacement Surgery: Complete Registry.
Authors: William M Semchuk, David Backstein, John Stewart, Esmat Dessouki, Mary Kwan, Pauline Lavoie, Maria Valois, Allan Mills, John W Eikelboom
Journal: Blood (2009)
High NGF Receptor Expression on ALL Blasts - A Novel Independent Prognostic Marker Identifying Patients with Favorable Outcome.
Authors: Anja Troeger, Ludmila Glouchkova, Hans-Juergen Laws, Helmut Hanenberg, Roland Meisel, Gritta Janka-Schaub, Ulrich Goebel, Dagmar Dilloo
Journal: Blood (2005)
Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b
Authors: Rachid El Fatimy, Shruthi Subramanian, Erik J. Uhlmann, Anna M. Krichevsky
Journal: Molecular Therapy (2017)

Glioblastoma (GBM) brain tumor remains among the most lethal and incurable human diseases. Oncogenic microRNA-10b (miR-10b) is strongly and universally upregulated in GBM, and its inhibition by antisense oligonucleotides (ASOs) reduces the growth of heterogeneous glioma cells; therefore, miR-10b represents a unique therapeutic target for GBM. Here we explored the effects of miR-10b gene editing on GBM. Using the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system, we investigated effects of miR-10b gene editing on the growth of cultured human glioma cells, tumor-initiating stem-like cells, and mouse GBM xenografts, as well as the oncogene-induced transformation of normal astrocytes. We show that GBM is strictly "addicted" to miR-10b and that miR-10b gene ablation is lethal for glioma cell cultures and established intracranial tumors. miR-10b loss-of-function mutations lead to the death of glioma, but not other cancer cell lines. We have not detected escaped proliferative clones of GBM cells edited in the miR-10b locus. Finally, neoplastic transformation of normal astrocytes was abolished by the miR-10b-editing vectors. This study demonstrates the feasibility of gene editing for brain tumors in vivo and suggests virus-mediated miR-10b gene ablation as a promising therapeutic approach that permanently eliminates the key regulator essential for tumor growth and survival. Glioblastoma (GBM) brain tumor remains among the most lethal and incurable human diseases. Oncogenic microRNA-10b (miR-10b) is strongly and universally upregulated in GBM, and its inhibition by antisense oligonucleotides (ASOs) reduces the growth of heterogeneous glioma cells; therefore, miR-10b represents a unique therapeutic target for GBM. Here we explored the effects of miR-10b gene editing on GBM. Using the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system, we investigated effects of miR-10b gene editing on the growth of cultured human glioma cells, tumor-initiating stem-like cells, and mouse GBM xenografts, as well as the oncogene-induced transformation of normal astrocytes. We show that GBM is strictly "addicted" to miR-10b and that miR-10b gene ablation is lethal for glioma cell cultures and established intracranial tumors. miR-10b loss-of-function mutations lead to the death of glioma, but not other cancer cell lines. We have not detected escaped proliferative clones of GBM cells edited in the miR-10b locus. Finally, neoplastic transformation of normal astrocytes was abolished by the miR-10b-editing vectors. This study demonstrates the feasibility of gene editing for brain tumors in vivo and suggests virus-mediated miR-10b gene ablation as a promising therapeutic approach that permanently eliminates the key regulator essential for tumor growth and survival.
Reduction of Urinary Bladder Activity in Transgenic Sickle Cell Disease Mice.
Authors: Mário Angelo Claudino, Carla Fernanda Franco-Penteado, Marcus A.F. Corat, Ana Paula Gimenes, Kleber Yotsumoto Fertrin, Luiz Augusto C Passos, Edson Antunes, Fernando Ferreira Costa
Journal: Blood (2009)
Ex Vivo Activated Natural Killer (NK) Cells from Myeloma Patients Kill Autologous Myeloma and Killing Is Enhanced by Elotuzumab
Authors: Tarun K. Garg, Susann Szmania, Jumei Shi, Katie Stone, Amberly Moreno-Bost, Paul Malbrough, Dario Campana, Bart Barlogie, Daniel Afar, Frits van Rhee
Journal: Blood (2008)
Interleukin-1 Receptor Antagonist (IL-1Ra) Targets the Proliferative Component in Early Stage Myeloma.
Authors: John A. Lust, Martha Q. Lacy, Angela Dispenzieri, Morie A. Gertz, Steven R. Zeldenrust, Philip R. Greipp, Thomas E. Witzig, Antje Hoering, Laurie L. Moon-Tasson, Michael M. Timm, S. Vincent Rajkumar, Kathleen A. Donovan
Journal: Blood (2004)