tbuckley/cabot-search huggingface dataset:
On the Occurrence of Plasma-Cell Leukemia in Various Strains of Mice&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: R RASK-NIELSEN, H GORMSEN
Journal: JNCI Journal of the National Cancer Institute (1956)

On the Occurrence of Plasma-Cell Leukemia in Various Strains of Mice Get access R. Rask-Nielsen, R. Rask-Nielsen The University Institute of Biochemistry (Head: Professor R. Ege, Ph.D.) and The University Institute of Legal Medicine (Head: Professor K. Sand, M.D.), Copenhagen, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar H. Gormsen H. Gormsen The University Institute of Biochemistry (Head: Professor R. Ege, Ph.D.) and The University Institute of Legal Medicine (Head: Professor K. Sand, M.D.), Copenhagen, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 5, April 1956, Pages 1137–1147, https://doi.org/10.1093/jnci/16.5.1137 Published: 01 April 1956 Article history Received: 26 September 1955 Published: 01 April 1956
Immunopotentiation with BCG. II. Modulation of the Response to Sheep Red Blood Cells2
Authors: T. E. Miller, G. B. Mackaness, P. H. Lagrange
Journal: JNCI Journal of the National Cancer Institute (1973)

Journal Article Immunopotentiation with BCG. II. Modulation of the Response to Sheep Red Blood Cells Get access T. E. Miller, T. E. Miller 3Trudeau Institute, Saranac Lake, N.Y. 12983 Search for other works by this author on: Oxford Academic PubMed Google Scholar G. B. Mackaness, G. B. Mackaness 3Trudeau Institute, Saranac Lake, N.Y. 12983 Search for other works by this author on: Oxford Academic PubMed Google Scholar P. H. Lagrange P. H. Lagrange 3Trudeau Institute, Saranac Lake, N.Y. 129834Lilly International Fellow, Eli Lilly and Company, Indianapolis, Ind Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 51, Issue 5, November 1973, Pages 1669–1676, https://doi.org/10.1093/jnci/51.5.1669 Published: 01 November 1973 Article history Received: 29 May 1973 Accepted: 23 July 1973 Published: 01 November 1973
Abstract A34: Id-1 mediates glioma stem cell chemoresistance to temozolomide
Authors: Angela Celebre, Megan YiJun Wu, Marc Remke, Michael Taylor, Jason Karamchandani, Sunit Das
Journal: Cancer Research (2015)

Abstract Introduction: Id-1 (inhibitor of differentiation and DNA binding) is a transcriptional regulator involved in stem cell maintenance. It has previously been shown to regulate self-renewal and confer chemoresistance in colon cancer stem cells. Id-1 has not been studied within the context of glioblastoma (GBM). We hypothesized that Id-1 mediates glioma stem cell (GSC) survival in response to chemotherapy and subsequently promotes tumour recurrence. Methods: To study the role of Id-1 in response to chemotherapy in vitro, three GSC lines were treated with the chemotherapy agent, temozolomide (TMZ), for seven days. Immunoblot and comparative QT-PCR were used to measure Id-1 protein and mRNA expression post-TMZ, respectively. To evaluate Id-1 expression in patient samples, we constructed a tissue microarray (TMA), which included 77 tissue specimens from patients diagnosed with GBM. Detailed clinical information was available for all of the selected samples, including survival times, treatment regimens, and primary versus recurrent tumor status. Immunohistochemistry was performed on the TMA and Id-1 protein expression was subsequently quantified using Panoramic Image Analysis Software Platform. Id-1 expression was correlated to survival outcome, along with other clinically relevant variables. We also employed a bioinformatics approach, exploring survival data from The Cancer Genome Atlas (TCGA) database that were based on Id-1 expression for patients diagnosed with GBM. Results: Id-1 expression in GSCs strongly increased in response to increasing doses of TMZ in vitro (0 uM, 25 uM, 100 uM). In patient tumor samples (n=77), Id-1 expression did not correlate with survival. However, among the recurrent patients who received chemotherapy after primary tumor resection (n=6), patients with increased Id-1 expression post-chemotherapy had a shorter latency to recurrence compared to patients with decreased Id-1 expression post-chemotherapy. Finally, the TCGA data corroborated our TMA patient data, finding comparable overall survival trends between patients with high versus low Id-1 expression. Conclusion: These findings demonstrate that Id-1 levels increase in response to chemotherapy, suggesting its potential role in chemoresistance. Since resistance to chemotherapeutic drugs is one of the major reasons for treatment failure in glioblastoma, Id-1 inactivation may serve as a novel strategy for enhancing therapy and improving outcomes in patients with the disease. Citation Format: Angela Celebre, Megan YiJun Wu, Marc Remke, Michael Taylor, Jason Karamchandani, Sunit Das. Id-1 mediates glioma stem cell chemoresistance to temozolomide. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr A34.
Patellofemoral pain syndrome
Authors: K Davidson
Journal: BMJ (2008)

Patellofemoral pain syndrome is a common problem that occurs in association with mild malalignment of the extensor mechanism of the knee or as a result of repetitive microtrauma from overuse. Patients most often present with retropatellar or peripatellar knee pain, which becomes especially noticeable when they climb or descend stairs. The diagnosis is usually made from the history and the physical examination, with relatively little information gained from other diagnostic aids. Treatment involves physical therapy, anti-inflammatory medication and the application of ice. In most patients, surgical treatment should be avoided. Patient motivation and adherence to the treatment regimen are critical to long-lasting improvement.
INDIAN DOCTORS AND VACANT APPOINTMENTS
Authors: C. Muthu
Journal: BMJ (1915)

that tonsillitis was frequently a rheumatic affec- tion.Here I am not so sure of my ground, and it now seems to me, with wider experience, that a diseased tonsil may probably be the port of entry of the specific organism which causes rheumatism.Be this as it may, the interesting clinical fact is that quite 75 per cent. of young patients who are the victims of acute rheumatism also suffer from diseased tonsils.I well remember pointing this out to a distinguished continental physician who attended my post-graduate class.He was sceptical on this point, but on his return home he wrote to me to say that his own statistics bore out my contention, and showed an even heavier percentage (80).If this discussion will have the effect of hastening the discovery of a specific curative treatment for acute rheumatism or, better still, the prevention of the disease it will have helped to achieve a great.boon.For I hold that rheumatism is the most
The Hunterian Oration
Authors: J. Marshall
Journal: BMJ (1885)

JOHN HUNTEn.-theobject of otur profound homage to-day-bore a name which, especially when uttered within these walls, excites the rememlbrance of many great achievements.Whilst, therefore, that name, by it §elf, forms a most appropriate introduction and close to an oration to be delivered in his honour, it suggests such a superabundance of material for occupying the brief but important hour which lies before us, and so many details wherewith to embellish the.sentences which must be fitted in between the Alpha and Omega of this discourse, that even the most skilful and intrepid orator might well quail before the task.Before, however, I, attempt to grapple with the difficulties of the undertaking, I will, in obedience to time-honoured -example, express,, in terms, I fear, too brief, our common regard for the memory of those recently deceased associat6sj whose special relations to the Col-
Induction of depression with oxotremorine in patients with Alzheimer's disease
Authors: K L Davis, E Hollander, M Davidson, B M Davis, R C Mohs, T B Horvath
Journal: American Journal of Psychiatry (1987)

Cholinergic neurotransmission has long been implicated in the development of depression. In this study seven patients with Alzheimer's disease were given oral oxotremorine, a long-acting cholinergic agonist, to assess the drug's effects on cognitive function. There were unexpected depressive reactions in five of the seven patients; three patients dropped out of the study because of the side effects. Cardiovascular effects of the drug were negligible, but its effect on memory and cognition remains unknown because of the small number of subjects who completed the study.
Alprazolam as treatment for a case of obsessive-compulsive disorder
Authors: G E Tesar, M A Jenike
Journal: American Journal of Psychiatry (1984)

Because of the anxiety accompanying his obsessions and a prior panic attack, an obsessive-compulsive man was given alprazolam, which reduced his obsessions and eliminated his compulsions. The authors discuss links between obsessive-compulsive disorder and other psychiatric disorders.
&lt;emph type="ital"&gt;Telephone&lt;/emph&gt;
Authors: Kristen M. Quaranta
Journal: JAMA (2008)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
The Nature and Staining Reactions of the Fibroma-Cell Inclusions of the Shope Fibroma of the Rabbit
Authors: Edwin R. Fisher
Journal: JNCI Journal of the National Cancer Institute (1953)

Journal Article The Nature and Staining Reactions of the Fibroma-Cell Inclusions of the Shope Fibroma of the Rabbit Get access Edwin R. Fisher Edwin R. Fisher Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 2, October 1953, Pages 355–363, https://doi.org/10.1093/jnci/14.2.355 Published: 01 October 1953 Article history Received: 27 April 1953 Published: 01 October 1953
Preliminary report on affective symptoms in the early stages of senile dementia of the Alzheimer type
Authors: J W Knesevich, R L Martin, L Berg, W Danziger
Journal: American Journal of Psychiatry (1983)

The authors rated 30 probands with senile dementia of the Alzheimer type and 30 healthy controls for depression at the beginning of a longitudinal study and 1 year later. Significant degrees of depression were not found in either group at either time.
Rugby Sevens: Olympic debutante and research catalyst
Authors: Ross Tucker
Journal: British Journal of Sports Medicine (2016)

Rugby Sevens will make its debut appearance at the Rio Olympic Games. Sevens is a variation of 15-a-side Rugby Union, and is played by teams of seven players over seven-minute halves. International competitions, including the Olympic Games, are typically played in a tournament format, which involve multiple matches per day over 2 or 3 days.

Exposure of Sevens to a global audience in the Olympic Games will stimulate interest in the sport, particularly among women and in nations where Rugby Union is not yet an established sport.

To date, research focus on Sevens has been on the elite level of the sport. Investigators have identified key determinants of performance,1 the match demands of Sevens,2 the effects of fatigue on performance and recovery,3 ,4 and strategies to optimise playing performance, preparation and recovery between matches.5 ,6 

There is also a research focus on injury epidemiology and prevention. This has been largely directed towards the elite game, due …
Syphilis in Denmark–Outbreak among MSM in Copenhagen, 2003-2004
Authors: S  A Cowan
Journal: Eurosurveillance (2004)

Denmark is currently experiencing an outbreak of syphilis that began in 2003 and has continued in 2004. Data from the national surveillance system show that most cases are in men who have sex with men (MSM), and that a large proportion of these patients are also HIV positive. The proportion of known HIV positive cases in MSM notified with syphilis during the outbreak has, however, not been significantly different from previous years. The majority of cases were reported from Copenhagen municipality, and 70% of the cases were acquired domestically. The outbreak does not seem to be affecting the age group under 20 years. We speculate that most of the MSM found with both syphilis and HIV were already HIV positive when they acquired syphilis infection.
EST-Based Analysis of Gene Expression in the Porcine Brain
Authors: Bing Zhang, Wu Jin, Yanwu Zeng, Zhixi Su, Songnian Hu, Jun Yu
Journal: Genomics Proteomics & Bioinformatics (2004)

Since pig is an important livestock species worldwide, its gene expression has been investigated intensively, but rarely in brain. In order to study gene expression profiles in the pig central nervous system, we sequenced and analyzed 43,122 high-quality 5' end expressed sequence tags (ESTs) from porcine cerebellum, cortex cerebrum, and brain stem cDNA libraries, involving several different prenatal and postnatal developmental stages. The initial ESTs were assembled into 16,101 clusters and compared to protein and nucleic acid databases in GenBank. Of these sequences, 30.6% clusters matched protein databases and represented function known sequences; 75.1% had significant hits to nucleic acid databases and partial represented known function; 73.3% matched known porcine ESTs; and 21.5% had no matches to any known sequences in GenBank. We used the categories defined by the Gene Ontology to survey gene expression in the porcine brain.
Anti-metastatic activity of interferon gamma in a xenograft model of Ewing’s sarcoma
Authors: M. S. Merchant, H. U. Kontny, C. L. Mackall
Journal: Journal of Clinical Oncology (2005)

8532 Background: Interferon gamma (IFNγ) plays a key role in anti-tumor surveillance through potent activation of T and NK cells. While IFNs have often been administered to bolster immune effects, there is evidence that IFNγ may have direct effects on tumor cells themselves. For example, we have shown that IFNγ can sensitize Ewings sarcoma cells to apoptosis induced by TRAIL. We sought to determine if IFNγ could also have a direct activity on tumor growth in the absence of immune effector cells. Methods: Xenografts were established by intramuscular injection of 1 million Ewings sarcoma cells into the lower extremity of SCID/bg mice. A single primary tumor then developed within 3–5 weeks and could be resected to yield a period of minimal residual disease prior to development of metastases of the lungs, soft tissues, and abdomen. Mice were treated during primary tumor growth (early) or during minimal residual disease (late) with recombinant human IFNγ (25,000IU/day), human IFNα (25,000IU/day), or doxorubicin (1mg/kg/week). Mice were followed for tumor growth and development of metastases. Results: Early treatment with IFNγ during primary tumor growth resulted in slower tumor growth than control groups but did not significantly decrease the requirement for tumor resections. However, early treatment with either IFNγ or IFNα resulted in a dramatic decrease in incidence of metastases compared to control or doxorubicin groups (30% or 67% vs 100% or 100%, respectively). The antimetastatic activity of IFN was also evident when early treatment was combined with doxorubicin. Late treatment following resection was not as effective in delaying or inhibiting metastases as ≤20% of mice in treatment groups remained free of metastases at 6 months post resection. Conclusions: IFNγ and, to a lesser extent, IFNα have distinct anti-metastatic activity in a xenograft model of physiologic metastases. Since the mice lack T cells and NK cells and the effects of IFNs are highly species specific, we conclude that this effect likely represents a direct action on the tumor cells themselves rather than an immunomodulatory effect. These preclinical findings support the incorporation of IFNγ into clinical trials for the treatment of metastatic Ewings sarcoma. No significant financial relationships to disclose.
A Successful Lumbosacral Amputation, Hemicorporectomy
Authors: J B AUST, K B ABSOLON
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension
Authors: Alexander M.K. Rothman, Nadine D. Arnold, Josephine A. Pickworth, James Iremonger, Loredana Ciuclan, Robert M.H. Allen, Sabine Guth-Gundel, Mark Southwood, Nicholas W. Morrell, Matthew Thomas, Sheila E. Francis, David J. Rowlands, Allan Lawrie
Journal: Journal of Clinical Investigation (2016)

Loss of the growth-suppressive effects of bone morphogenetic protein (BMP) signaling has been demonstrated to promote pulmonary arterial endothelial cell dysfunction and induce pulmonary arterial smooth muscle cell (PASMC) proliferation, leading to the development of pulmonary arterial hypertension (PAH). MicroRNAs (miRs) mediate higher order regulation of cellular function through coordinated modulation of mRNA targets; however, miR expression is altered by disease development and drug therapy. Here, we examined treatment-naive patients and experimental models of PAH and identified a reduction in the levels of miR-140-5p. Inhibition of miR-140-5p promoted PASMC proliferation and migration in vitro. In rat models of PAH, nebulized delivery of miR-140-5p mimic prevented the development of PAH and attenuated the progression of established PAH. Network and pathway analysis identified SMAD-specific E3 ubiquitin protein ligase 1 (SMURF1) as a key miR-140-5p target and regulator of BMP signaling. Evaluation of human tissue revealed that SMURF1 is increased in patients with PAH. miR-140-5p mimic or SMURF1 knockdown in PASMCs altered BMP signaling, further supporting these factors as regulators of BMP signaling. Finally, Smurf1 deletion protected mice from PAH, demonstrating a critical role in disease development. Together, these studies identify both miR-140-5p and SMURF1 as key regulators of disease pathology and as potential therapeutic targets for the treatment of PAH.
Commentary: how can experts and novices learn together?
Authors: Ed Peile
Journal: BMJ (2004)

Rapid responses to this case have been less numerous but perhaps more erudite and thought provoking than we have come to expect from previous interactive case reports.1 Could it be that the rapidest responders' expertise in evidence based medicine, diabetes, and reproductive medicine deterred others from contributing? We know that experts and novices learn in different ways and that experts are not always the best teachers for novices,2 but what about their interaction when working and learning together?

More advanced learners can inhibit contributions from the less expert in schools, and this effect, postulated in medical education, has been observed in learning about evidence based health care.3 Benner comments that “proficient performers are best taught by use of case studies where their ability to grasp the situation is solicited and taxed.”2 Medical case based learning is used at disparate levels of expertise, ranging from small group work to grand rounds. The trick is to ensure that learners at different stages can each work at their own level without disrupting the learning of others.

What does this mean for medical educators? Firstly, a skilled group facilitator may be able to hold the ring and balance the learning to ensure that everyone goes away from a learning encounter with something learnt, but they may learn sequentially rather than simultaneously. Novices may learn from seeing how experts develop their reasoning, and experts exposed to the thought processes of the less experienced may reflect on their unconscious expertise.

Much of modern educational thinking about professional learning is founded on Lave and Wenger's notion that learning is “a process of participation in communities of practice, participation that is at first legitimately peripheral but that increases gradually in engagement and complexity.”4

BMJ interactive case reports attempt to stimulate the formation of a transient community of practice on the web pages. Gilly Salmon coined the term “cafelattia learning” to describe online communities, such as those with a common professional interest, learning by being intellectually extended by dialogue and challenge from others.5 She has valuable advice for those facilitating e-learning in this context.
Higher all-cause mortality in children during autumn 2009 compared with the three previous years: pooled results from eight European countries
Authors: A Mazick, B Gergonne, F Wuillaume, K Danis, A Vantarakis, H Uphoff, G Spiteri, T van 't Klooster, C Junker, M Holmberg, K Mølbak
Journal: Eurosurveillance (2010)

The paper describes weekly fluctuations of all-cause mortality observed in eight European countries during the period between week 27 and 51, 2009, in comparison with three previous years. Our preliminary data show that the mortality reported during the 2009 influenza pandemic did not reach levels normally seen during seasonal influenza epidemics. However, there was a cumulative excess mortality of 77 cases (1 per 100,000 population) in 5-14-year-olds, and possibly also among 0-4-year-olds.