tbuckley/cabot-search huggingface dataset:
Sweetened Beverage Consumption and Risk of Biliary Tract and Gallbladder Cancer in a Prospective Study
Authors: Susanna C. Larsson, Edward L. Giovannucci, Alicja Wolk
Journal: JNCI Journal of the National Cancer Institute (2016)

Background: Sugar-sweetened beverage consumption raises blood glucose concentration and has been positively associated with weight gain and type 2 diabetes, all of which have been implicated in the development of biliary tract cancer (BTC). This study examined the hypothesis that sweetened beverage consumption is positively associated with risk of BTC in a prospective study. Methods: The study population comprised 70 832 Swedish adults (55.9% men, age 45-83 years) from the Swedish Mammography Cohort and Cohort of Swedish Men who were free of cancer and diabetes and completed a food frequency questionnaire at baseline. Incident BTC case patients were ascertained through linkage with the Swedish Cancer Register. Cox proportional hazards regression model was used to analyze the data. All statistical tests were two-sided. Results: During a mean follow-up of 13.4 years, 127 extrahepatic BTC case patients (including 71 gallbladder cancers) and 21 intrahepatic BTC case patients were ascertained. After adjustment for other risk factors, women and men in the highest category of combined sugar-sweetened and artificially sweetened beverage consumption had a statistically significantly increased risk of extrahepatic BTC and gallbladder cancer. The multivariable hazard ratios for two or more servings per day (200 mL/serving) of sweetened beverages compared with no consumption were 1.79 (95% confidence interval [CI] = 1.02 to 3.13) for extrahepatic BTC and 2.24 (95% CI = 1.02 to 4.89) for gallbladder cancer. The corresponding hazard ratio for intrahepatic BTC was 1.69 (95% CI = 0.41 to 7.03). Conclusions: These findings support the hypothesis that high consumption of sweetened beverages may increase the risk of BTC, particularly gallbladder cancer.
A case of Crimean-Congo haemorrhagic fever in Greece, June 2008
Authors: A Papa, H C Maltezou, S Tsiodras, V G Dalla, T Papadimitriou, I Pierroutsakos, G N Kartalis, A Antoniadis
Journal: Eurosurveillance (2008)

A 46-year-old woman with disseminated intravascular coagulation (DIC) died in a hospital in Alexandroupoli, in north-eastern Greece, in the end of June 2008. The woman was admitted to the hospital four days earlier, with fever, malaise, myalgia, chills and abdominal pain. One day before death, her condition deteriorated rapidly and she developed heavy hemorrhage from the genital tract, DIC and multi-organ failure. The patient reported a tick bite four days before admission, and that she had tried to remove the tick herself. No travel abroad was reported. She was engaged in agricultural activities in a rural area near the town of Komotini, in Rhodope prefecture, south of the Greek-Bulgarian border.
A Ten Year Appraisal of the Treatment of Squamous Cell Carcinoma of the Esophagus
Authors: S KAY
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OC-059 The impact of disease progression with neoadjuvant chemotherapy in patients undergoing resection of colorectal liver metastases
Authors: FK Welsh, K Chandrakumaran, TG John, AB Cresswell, M Rees
Journal: Gut (2015)

<h3>Introduction</h3> Controversy exists as to the survival benefit of liver resection in patients with colorectal liver metastases (CRLM) whose disease has progressed despite neoadjuvant chemotherapy. This study looked at outcomes after liver resection for CRLM, in relation to response to neoadjuvant chemotherapy and in those patients whose disease progressed, specifically asked whether the pattern of disease progression influenced survival. <h3>Method</h3> Clinical, pathologic, and complete follow-up (median 35.3 months) data were prospectively collected from 582 consecutive patients who had neoadjuvant chemotherapy prior to resection of CRLM with curative intent at a single centre (March 1998–March 2013). Patients were divided into four groups according to their response to chemotherapy: complete response (CR) (n = 32), partial response (PR) (n = 447), stable disease (SD) (n = 62) and progressive disease (PD) (n = 41). Patients with PD were subdivided into those whose metastases increased in size (PDs) (n = 19) and those whose metastases increased in both size and number (PDsn) (n = 22). Cumulative disease-free survival (DFS) and cancer-specific survival (CSS) were calculated using Kaplan Meier analysis. <h3>Results</h3> At the time of liver surgery, patients with PD had a higher median [interquartile range (IQR)] CEA in ug/L [20.5 (4.1–57.8)] compared to patients with CR [2.0 (1.1–10.0)], PR [4.0 (1.9–13.0)] or SD [4.0 (1.2–13.5), p = 0.001]. Patients with PD also had a significantly higher median (IQR) number of CRLM [3 (1–6), p = 0.001] and size of metastases [55 (20–80)mm, p = 0.001], compared to patients with CR [1 (0–1) and 1 (0–4) mm], PR [2 (1–4) and 25 (20–40) mm] or SD [2 (1–3) and 30 (20–40) mm]. No differences were observed regarding patient demographics, the extent of hepatic resection, Clavien-Dindo Grade 3/4 complications, in-hospital mortality or clear resection margin rates. Cumulative 5 year DFS and CSS was significantly higher in the CR patients (50.1% and 53.2%), compared to PR (42.1% and 44.3%), SD (37.1% and 39.4%) or PD (21.0% and 23.8%, p = 0.001 and 0.017 respectively). However, in the patients with PD, the PDs patients had significantly better DFS and CSS (37.5% and 39.1%) compared to the PDsn patients (10.4% and 12.4%, p = 0.046 and 0.045 respectively), such that their DFS and CSS was comparable to those patients with SD. <h3>Conclusion</h3> Progression on neoadjuvant chemotherapy <i>per se</i>for patients with CRLM should not be considered a contraindication for potentially curative hepatectomy. These data suggest that the type of disease progression is important and that patients whose metastases increase in size only will still derive significant survival benefit. <h3>Disclosure of interest</h3> None Declared.
Combined Treatment of Advanced Leukemia (L1210) in Mice with Amethopterin and 6-Mercaptopurine&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: John M. Venditti, Stewart R. Humphreys, Nathan Mantel, Abraham Goldin
Journal: JNCI Journal of the National Cancer Institute (1956)

Combined Treatment of Advanced Leukemia (L1210) in Mice with Amethopterin and 6-Mercaptopurine Get access John M. Venditti, John M. Venditti Laboratory of Chemical Pharmacology, and Biometry and Epidemiology Branch, National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Stewart R. Humphreys, Stewart R. Humphreys Laboratory of Chemical Pharmacology, and Biometry and Epidemiology Branch, National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Nathan Mantel, Nathan Mantel Laboratory of Chemical Pharmacology, and Biometry and Epidemiology Branch, National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar Abraham Goldin Abraham Goldin Laboratory of Chemical Pharmacology, and Biometry and Epidemiology Branch, National Cancer Institute,3Bethesda, Maryland Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 5, November 1956, Pages 631–638, https://doi.org/10.1093/jnci/17.5.631 Published: 01 November 1956 Article history Received: 29 June 1956 Published: 01 November 1956
The Infection of Cells in Tissue Culture with Rous Sarcoma Virus
Authors: Katherine K. Sanford, Gwendolyn D. Likely, W. Ray Bryan, Wilton R. Earle
Journal: JNCI Journal of the National Cancer Institute (1952)

The Infection of Cells in Tissue Culture with Rous Sarcoma Virus Get access Katherine K. Sanford, Katherine K. Sanford Laboratory of Biology, National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Gwendolyn D. Likely, Gwendolyn D. Likely Laboratory of Biology, National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar W. Ray Bryan, W. Ray Bryan Laboratory of Biology, National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar Wilton R. Earle Wilton R. Earle Laboratory of Biology, National Cancer Institute2Bethesda 14, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 12, Issue 6, June 1952, Pages 1317–1343, https://doi.org/10.1093/jnci/12.6.1317 Published: 01 June 1952 Article history Received: 29 February 1952 Published: 01 June 1952
IgG and IgG 4 to 91 allergenic molecules in early childhood by route of exposure and current and future IgE sensitization: Results from the Multicentre Allergy Study birth cohort
Authors: Alina Schwarz, Valentina Panetta, Antonio Cappella, Stephanie Hofmaier, Laura Hatzler, Alexander Rohrbach, Olympia Tsilochristou, Carl-Peter Bauer, Ute Hoffmann, Johannes Forster, Fred Zepp, Antje Schuster, Raffaele D'Amelio, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
Journal: Journal of Allergy and Clinical Immunology (2016)
First multicenter experience with thermotherapy and mitomycin of high risk NMIBC with a new recirculation system (COMBAT).
Authors: Thomas Alexander Voegeli, Bjoern Volkmer
Journal: Journal of Clinical Oncology (2016)

425 Background: At a temperature of 43° (109°F) cytotoxicity of mitomycin increases 10 fold to tumor cells if used for instillation therapy of superficial bladder cancer (NMIBC).In the last years high organ preservation rates were reported for high risk NMIBC after radiofrequency induced hyperthermia and mitomycin (Synergo System).Unfortunately side effects were frequent and discontinuitation of 40% were reported with this method thus thermotherapy combined with instillation this therapy has not been very common.We here report about the first experience with a newly developed device using a recirculation heating system (COMBAT). Methods: After diagnosis by complete TUR/ReTUR patients received 40 mg mitomycin (mito-extra,medac) via transurethral catheter for 1 h heated up to constant 43° by a circulation pump system (COMBAT). Side effects were recorded pprospectively before and after each teratment and during follow up and success was validated by TUR/biopsy if possible. Results: A total of 20 patients were treated from 11/14-9/15 in 5 institutions. Follow up until now is 1-10 month (mean 8 m). All patients had high risk NMIBC including BCG failures. Therapy must be abondened in 1 patient after the 5th treatment, 50% had dysuria during treatment but symptoms decreased after the last treatment in all patients. 2 patients experienced mild allergic reaction also seen under conventional instillation therapy with mitomycin and were treated by corticosteroids. ReTUR was performed in 17/20 patients and revealed a persistent/recurrent tumor pTa GIII in 1 out of 20 patients. Conclusions: Compared to the microwave driven heating system the new device with recirculation of heated mitomycin seems to have less side effects without major complications. Treatment discontinuitation was recorded in 1/20 patients. Given the assumption that this system has the same high rate of organ preservation as the Synergo System at even much lower costs, it may alter the therapy algorythm in high risk NMIBC. Despite our first promising oncological results further research with longer follow up is necessary.Two prospective randomized studies are now underway in England and Spain and first results are awaited in 2 years.
A description and evaluation of an outpatient intensive psychotherapy center
Authors: W M Swenson, H R Martin
Journal: American Journal of Psychiatry (1976)

The intensive psychotherapy center described and evaluated in this paper is unique because of its intensity and the fact that available treatment modalities are integrated into the program. Pateints are literally immersed in therapy on a full-time basis for an average of 3 weeks. Assessment of the program through the use of questionnaires completed by 335 patients at the time of discharge showed significant improvement in their presenting symptoms, interpersonal relationships, ability to work, and general level of comfort. An 8-month follow-up study of 171 patients revealed that this improvement was retained.
Infectious diseases surveillance activities in the North of Portugal, during the EURO 2004 football tournament
Authors: G Gonçalves, L Castro, A  M Correia, Laurinda Queirós
Journal: Eurosurveillance (2005)

A European football tournament (EURO 2004) took place in Portugal, from the 12 June to the 4 July 2004. Portugal’s Northern Regional Health Authority serves a population of 3.2 million people. This region hosted 12 matches, more than any other region. We describe the communicable disease surveillance activities in the region, during EURO 2004. Ten foodborne outbreaks, seven cases of meningococcal disease and one case of legionnaires’ disease, were detected. Visitors were not affected, furthermore, cases among residents seemed not to be influenced by the presence of thousands of visitors. A similar pattern has been observed at other mass gatherings where special surveillance activities were implemented. This does not reduce the importance of public health surveillance during such mass gatherings. Furthermore, evaluation of this special activities should be an opportunity to put, issues of communicable disease surveillance resources, priorities, organisation and training back on the agenda.
Prognostic impact of cytogenetic aberrations in AL amyloidosis patients after high-dose melphalan: a long-term follow-up study
Authors: Tilmann Bochtler, Ute Hegenbart, Christina Kunz, Axel Benner, Christoph Kimmich, Anja Seckinger, Dirk Hose, Hartmut Goldschmidt, Martin Granzow, Peter Dreger, Anthony D. Ho, Anna Jauch, Stefan O. Schönland
Journal: Blood (2016)
Distribution of Anticancer Agents in Spontaneous Animal Tumors. I. Regional Blood Flow and Methotrexate Distribution in Canine Lymphosarcoma2
Authors: James A. Straw, Michael M. Hart, Philip Klubes, Daniel S. Zaharko, Robert L. Dedrick
Journal: JNCI Journal of the National Cancer Institute (1974)

Regional blood flow and distribution of methotrexate (MTX) were measured in involved lymph nodes of dogs with spontaneous lymphosarcoma. Regional blood flow was determined by a thermal dilution technique. Although blood flow was nonuniform, i.e., peripheral areas had much higher blood flows than internal portions of the tumors, even the internal regions of these tumors had flow rates comparable to such well-perfused tissues as the brain. Concentrations of 3H-MTX in plasma and tumor were measured at intervals up to 90 minutes after intravenous administration of MTX at 5 dose levels. 14C-inulin was used to measure extracellular space in the tumor which permitted calculation of intracellular concentrations of MTX. Results indicated that MTX accumulated at intracellular sites by means of a saturable transport mechanism which was rate limiting for delivery of the drug to the active site. Measurement of dihydrofolate reductase activity in these tumors demonstrated a correlation between accumulation of MTX in the intracellular compartment and inhibition of the enzyme.
Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015
Authors: Alexis Pillsbury, Patrick Cashman, Alan Leeb, Annette Regan, Darren Westphal, Tom Snelling, Christopher Blyth, Nigel Crawford, Nicholas Wood, Kristine Macartney
Journal: Eurosurveillance (2015)

Increased febrile reactions in Australian children from one influenza vaccine brand in 2010 diminished confidence in influenza immunisation, highlighting the need for improved vaccine safety surveillance. AusVaxSafety , a national vaccine safety surveillance system collected adverse events in young children for 2015 influenza vaccine brands in real time through parent/carer reports via SMS/email. Weekly cumulative data on 3,340 children demonstrated low rates of fever (4.4%) and medical attendance (1.1%). Fever was more frequent with concomitant vaccination.
Antagonizing Integrin β3 Increases Immunosuppression in Cancer
Authors: Xinming Su, Alison K. Esser, Sarah R. Amend, Jingyu Xiang, Yalin Xu, Michael H. Ross, Gregory C. Fox, Takayuki Kobayashi, Veronica Steri, Kirsten Roomp, Francesca Fontana, Michelle A. Hurchla, Brett L. Knolhoff, Melissa A. Meyer, Elizabeth A. Morgan, Julia C. Tomasson, Joshua S. Novack, Wei Zou, Roberta Faccio, Deborah V. Novack, Stephen D. Robinson, Steven L. Teitelbaum, David G. DeNardo, Jochen G. Schneider, Katherine N. Weilbaecher
Journal: Cancer Research (2016)

Abstract Integrin β3 is critical for tumor invasion, neoangiogenesis, and inflammation, making it a promising cancer target. However, preclinical and clinical data of integrin β3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin β3 could affect tumor immunity and evaluated tumors in mice with deletion of integrin β3 in macrophage lineage cells (β3KOM). β3KOM mice had increased melanoma and breast cancer growth with increased tumor-promoting M2 macrophages and decreased CD8+ T cells. Integrin β3 antagonist, cilengitide, also enhanced tumor growth and increased M2 function. We uncovered a negative feedback loop in M2 myeloid cells, wherein integrin β3 signaling favored STAT1 activation, an M1-polarizing signal, and suppressed M2-polarizing STAT6 activation. Finally, disruption of CD8+ T cells, macrophages, or macrophage integrin β3 signaling blocked the tumor-promoting effects of integrin β3 antagonism. These results suggest that effects of integrin β3 therapies on immune cells should be considered to improve outcomes. Cancer Res; 76(12); 3484–95. ©2016 AACR.
AB0773 Attitude of Doctor and Patient to Ankylosing Spondylitis: Questions of Understanding
Authors: L. Myasoutova, S. Lapshina
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Effective control of ankylosing spondylitis (AS) activity involves prolonged drug therapy primarily NSAIDs and active participation of the patient in treatment, performing of recommendations on non-pharmacological treatment. Is it always effective physician-patient interaction in relation to treatment. <h3>Objectives</h3> To identify the most significant problems for AS patient about the disease in order to create a system of effective interaction: physician – AS patient. <h3>Methods</h3> 30 patients with confirmed AS diagnosis, the average disease duration 5, 7±3,2 years, mean age 34,4±12. 8 years, responded to 10 survey questions regarding their understanding of the disease and treatment issues and the impact on daily life with the need to evaluate the importance of each question on a scale from 1 to 10. Doctors rheumatologists (n=10) and physicians (n=20) answered the same questions from the position what they think is important for patients. Responses were ranked and compared. <h3>Results</h3> Considering the young age of patients, priority for patients and doctors was the outlook for the future (1). Important for doctors and patients were issues related restrictions on daily life (patients - 4 place, doctors - 2nd place) and earning capacity (patients - 3 place, doctors - 5th place). At the same time, doctors underestimate (10th place) the complexity of the patient (2nd place) associated with the need to exercise constantly. Physicians overestimated the importance of persistent pain for patients (4th place) and side effects of drugs (2nd place), patients put on the importance of these issues at 7 and 5th place respectively. <h3>Conclusions</h3> In communicating with the patient doctor needs to pay more attention to the importance of non-pharmacological treatment, in particular right physical exercises. Understanding the patients view to their condition will improve the efficiency of AS control. <h3>Disclosure of Interest</h3> None declared
Tattoos, Beer, and Bow Ties
Authors: Annie Janvier
Journal: JAMA Pediatrics (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Pediatrics HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Pediatrics journal
Conjunctival Melanoma on 18F-FDG PET/CT as a Second Primary Cancer
Authors: Szu-Ying Tsai, Yu-Chien Shiau, Shan-Ying Wang, Yen-Wen Wu
Journal: Clinical Nuclear Medicine (2015)

Herein we present the F-FDG PET/CT findings in conjunctival melanoma as a second primary cancer in a 56-year-old Taiwanese man with a history of small lymphocytic lymphoma/chronic lymphocytic leukemia and nasal cavity carcinoma under remission. The right eye lesion slowly progressed since noted by the patient himself 2 years ago, but he refused biopsy and further treatment including surgery. Either small lymphocytic lymphoma/chronic lymphocytic leukemia or conjunctival melanoma is extremely rare in Asians, left alone in combination with a third malignancy of nasal cavity carcinoma. FDG PET/CT could effectively evaluate malignancies with multiple primary origins.