tbuckley/cabot-search huggingface dataset:
Alpha-Type 1-Polarized Dendritic Cells Pulsed with Apoptotic Allogeneic Myeloma Cell Line Could Induce the Strong CTL Responses against Autologous Myeloma Cells.
Authors: Deok-Hwan Yang, Mi-Hyun Kim, Cheol-Yi Hong, Jae-Sook Ahn, Yeo-Kyeoung Kim, Ik-Joo Chung, Hyeoung-Joon Kim, Je-Jung Lee
Journal: Blood (2009)
GW27-e0662 Ivabradine reduces the expression of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel in dogs with age-related atrial fibrillation
Authors: Li Yaodong, Yutong Ji, Xianhui Zhou, Qiang Xing, Yanmei Lu, Jianghua Zhang, Baopeng Tang
Journal: Journal of the American College of Cardiology (2016)
TCT-78 Efficacy of Long-Term Ticagrelor in Stented Patients in PEGASUS-TIMI 54
Authors: Marc P. Bonaca, Deepak L. Bhatt, Philippe G. Steg, Andrej Budaj, Sameer Bansilal, Robert F. Storey, KyungAh Im, Giulia Magnani, T. Oude Ophuis, Michael Ruda, Christian Hamm, Jindrich Spinar, Robert Gabor Kiss, Rafael Diaz, Frans J. Van de Werf, Gilles Montalescot, Eva C. Jensen, Peter Held, Eugene Braunwald, Marc S. Sabatine
Journal: Journal of the American College of Cardiology (2015)
Antimyeloma Action of the Multikinase Inhibitor TG02
Authors: Stela Álvarez-Fernández, Susana Hernández-García, Xi Chen, Enrique M. Ocio, Bruno Paiva, Kay R. Meshow, Lynn A. Cheatham, Francis Burrows, Jesús F. San Miguel, Atanasio Pandiella
Journal: Blood (2010)
TCT-745 Guideline Based Referral for Septal Reduction Therapy In Patients With Hypertrophic Cardiomyopathy Is Associated With Excellent Clinical Outcomes: Longitudinal Follow-Up Of A Large, Single-Center Experience
Authors: Johny S. Kuttab, Yuvrajsinh Parmar, Ethan Rowin, Saket Sanghai, Hassan Rastegar, Martin Maron, Carey D. Kimmelstiel
Journal: Journal of the American College of Cardiology (2015)
TCT-353 Variability in Quantitative Precision of Intravascular Imaging Modalities: Head-to-Head Comparison of Currently Available Coronary Imaging Systems
Authors: Yuhei Kobayashi, Hideki Kitahara, Shigemitsu Tanaka, Kozo Okada, Takumi Kimura, Fumiaki Ikeno, Paul Yock, Peter J. Fitzgerald, Yasuhiro Honda
Journal: Journal of the American College of Cardiology (2015)
PTH-063 Different colectomy rates for ulcerative colitis across ethnic groups in england: Abstract PTH-063 Table 1
Authors: R Misra, A Askari, O Faiz, N Arebi
Journal: Gut (2015)

<h3>Introduction</h3> Previous epidemiological studies suggest a higher rate of pan-colonic disease in South Asians (SA) compared with Caucasians. There is limited data on disease severity across ethnic groups. Refractory disease and development of dysplasia indicate aggressive disease and are both indications for colectomy. The aim of the study was to compare the risk of colectomy for ulcerative colitis (UC) in SA migrants to Caucasians. <h3>Method</h3> Patients with UC were identified from a national administrative dataset (Hospital Episode Statistics – HES) between 1997–2012 according to ICD-10 diagnosis code K51 for UC. From the cases coded for ethnicity, colectomy cases were identified according to the Office of Population Censuses and Surveys (OPCS) codes. The colectomy rate for each ethnic group was calculated as the proportion of patients who underwent colectomy from the total UC cases for that group. The median age at time of colectomy was calculated for each ethnic group. Chi-squared testing was used to determine significant differences in colectomy rate and Kruskal-Wallis test to ascertain differences in age at colectomy between ethnic groups. <h3>Results</h3> Of 212,430 UC cases, 74,988 (35.3%) were coded for ethnicity. Of these cases most were White Europeans (Caucasians) 69,208/74,988 (92.3%). The SA group consisted of: 1,954/74,988 (2.6%) Indian, 832/74,988 (1.1%) Pakistani and 129/74,988 (0.2%) Bangladeshi (Table 1). Indians had a significantly higher colectomy rate than White Europeans (10.8% vs 7.4%, p &lt; 0.001). In contrast Pakistanis had a similar (7.0%) and Bangladeshis a significantly lower (4.7%) colectomy rate than the White European group. (7.4%, p &lt; 0.001). SAs undergoing colectomy were significantly younger than White Europeans for each ethnic group (median age; Bangladeshis - 29 years, Pakistanis - 37 years and Indians – 41 years, compared with White Europeans – 49 years, p &lt; 0.001). <h3>Conclusion</h3> The colectomy rate is higher in Indians compared to White Europeans. Across SA ethnic groups there are differences in colectomy rate. All SA groups required a colectomy for UC at a younger age than White Europeans. These findings suggest a more aggressive phenotype in SAs and should be validated with a prospectively recruited ethnic cohort. This will also allow examination of contributing factors. <h3>Disclosure of interest</h3> None Declared.
TCT-459 Effect of bleeding complications as assessed by the National Cardiovascular Data Registry (NCDR) bleeding risk calculator in patients undergoing Primary Percutaneous Coronary Intervention
Authors: Ashim Aggarwal, Sandeep Banga, R.P. McRae, Sudhir Mungee, Tinoy Kizhakekuttu
Journal: Journal of the American College of Cardiology (2015)
Prenatal Exposure to Glycol Ethers and Neurocognitive Abilities in 6-Year-Old Children: The PELAGIE Cohort Study
Authors: Rémi Béranger, Ronan Garlantézec, Gaïd Le Maner-Idrissi, Agnès Lacroix, Florence Rouget, Jessica Trowbridge, Charline Warembourg, Christine Monfort, Florent Le Gléau, Marylène Jourdin, Luc Multigner, Sylvaine Cordier, Cécile Chevrier
Journal: Environmental Health Perspectives (2016)

Background:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families of organic solvents, little is known about the impact of GE on the neurodevelopment of infants and children.Objectives:We investigated the relation between urinary concentrations of GE metabolites in pregnant women and neurocognitive abilities in their 6-year-old children in the PELAGIE mother–child cohort.Methods:Five GE metabolites were measured in first morning void urine samples of 204 French pregnant women in early pregnancy (< 19 weeks of gestation). Psychologists assessed the neurocognitive abilities of their 6-year-old children with the Wechsler Intelligence Scale for Children IV (WISC) and the Developmental Neuropsychological Assessment (NEPSY). We analyzed the results with linear (WISC) and Poisson regression models (NEPSY), adjusted for potential confounders, including child's stimulation at home.Results:GE metabolites were detected in 90–100% of maternal urine samples. The WISC Verbal Comprehension score was significantly lower for children with the highest tertile of urinary phenoxyacetic acid (PhAA) [β (third vs. first tertile) = –6.53; 95% CI: –11.44, –1.62]. Similarly, the NEPSY Design Copying subtest score was lower in those with the highest tertile of urinary ethoxyacetic acid (EAA) [β (third vs. first tertile) = –0.11; 95% CI: –0.21, 0.00]. The other GE metabolites we studied were not significantly associated with WISC or NEPSY scores.Conclusions:Prenatal urine concentrations of two GE metabolites were associated with lower WISC Verbal Comprehension Index scores and NEPSY Design Copying subscale scores, respectively, at age 6 years. PhAA is the primary metabolite of 2-phenoxyethanol (EGPhE), which is commonly found in cosmetics, and precursors of EAA are frequently used in cleaning agents. Additional research is needed to confirm our findings and further explore potential effects of prenatal GE exposures on neurocognitive performance in children.Citation:Béranger R, Garlantézec R, Le Maner-Idrissi G, Lacroix A, Rouget F, Trowbridge J, Warembourg C, Monfort C, Le Gléau F, Jourdin M, Multigner L, Cordier S, Chevrier C. 2017. Prenatal exposure to glycol ethers and neurocognitive abilities in 6-year-old children: the PELAGIE cohort study. Environ Health Perspect 125:684–690; http://dx.doi.org/10.1289/EHP39
Ponatinib Efficacy and Safety in Patients with the T315I Mutation: Long-Term Follow-up of Phase 1 and Phase 2 (PACE) Trials
Authors: Michael J. Mauro, Jorge E. Cortes, Andreas Hochhaus, Michele Baccarani, Timothy P. Hughes, Francois Guilhot, Michael W. Deininger, Hagop M. Kantarjian, Neil P. Shah, Dale Bixby, Ian Flinn, Stephanie Lustgarten, Victor M. Rivera, Frank G. Haluska, Tim Clackson, Moshe Talpaz
Journal: Blood (2014)
Durable Molecular Remissions in Patients with Relapsed CML Post Allogeneic Stem Cell Transplantation upon Treatment with Imatinib-Mesylate (Glivec®, STI-571). Follow-Up Results of a Phase II Open-Label Study.
Authors: G. Hess, D. Bunjes, W. Siegert, R. Schwerdtfeger, G. Ledderose, B. Waßmann, G. Kobbe, M. Bornhäuser, A. Hochhaus, A. J. Ullmann, T. Kindler, H. Geschaidmeier, C. Huber11, T. Fischer12
Journal: Blood (2004)
Closure of pancreatic intraductal papillary mucinous carcinoma-colonic fistula using an over-the-scope clip
Authors: Hiroshi Yamauchi, Mitsuhiro Kida, Eiji Miyata, Kosuke Okuwaki, Kana Kawagishi, Hiroshi Imaizumi, Wasaburo Koizumi
Journal: Endoscopy (2016)

Pancreatic intraductal papillary mucinous carcinoma (IPMC) can rupture and lead to fistula formation in multiple organs [1] [2]. An over-the-scope clip (OTSC) has been used to close gastrointestinal perforations and fistulas [3]. We describe a patient in whom the OTSC was useful for the closure of an IPMC-colonic fistula accompanied by infection.
TCT-18 Impact of Incomplete Revascularization after Percutaneous Coronary Intervention as Assessed by the SYNTAX Revascularization Index in Complex Coronary Artery Disease: A SEEDS Substudy
Authors: Nicolas Bettinger, Changdong Guan, Yuejin Yang, Martin Leon, Bo Xu, Philippe Genereux
Journal: Journal of the American College of Cardiology (2015)
Susceptibility of Young and of Adult Mice to the Mammary-Tumor Agent
Authors: Howard B. Andervont
Journal: JNCI Journal of the National Cancer Institute (1945)

Journal Article Susceptibility of Young and of Adult Mice to the Mammary-Tumor Agent Get access Howard B. Andervont Howard B. Andervont Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 5, Issue 6, June 1945, Pages 397–401, https://doi.org/10.1093/jnci/5.6.397 Published: 01 June 1945
TCT-484 Impact of Left Main Percutaneous Coronary Intervention Operator’s Experience and Volume on Outcomes after Left Main Percutaneous Coronary Intervention (PCI): Insight from a Cohort of 1,948 Patients
Authors: Bo Xu, Nicolas Bettinger, Yuejin Yang, Shubin Qiao, Yongjian Wu, Changdong Guan, Run-Lin Gao, Philippe Genereux
Journal: Journal of the American College of Cardiology (2015)
The Mobilization Effects of G-CSF, GM-CSF and Darbepoetin-α for Allogeneic Peripheral Blood Stem Cell Transplantation.
Authors: Shi Nae Kim, Sang Kyun Sohn, Jong Gwang Kim, Yee Soo Kim, Yoon Young Cho, Joon Ho Moon, Byung Min Ahn, Soo Jung Lee, Yun Jeong Kim
Journal: Blood (2007)
GW27-e0345 The retrospective analysis of clinical characteristics and risk factors in elderly patients that complicated with pneumonia after ischemic stroke
Authors: Xiaoyong Xiao, Zi Ye, Peng Jiang, Zhenhua Huang, Yna Xiong, Jia Xu, Jinli Liao, Zhihao Liu, Zhengke Huang, Hong Zhan
Journal: Journal of the American College of Cardiology (2016)
THE EPIDEMIOLOGY OF A RABBIT RESPIRATORY INFECTION
Authors: Leslie T. Webster
Journal: The Journal of Experimental Medicine (1924)

In order to understand more clearly the phenomena which underlie the epidemic spread of bacterial disease in man, Flexner and his associates and Topley with his collaborators 2 have studied experimentally a native animal enteric disease, mouse typhoid.In the course of these investigations an attempt has been made to reproduce mass reactions which arise in instances of human epidemics and to define the relative importance of such factors as microbic distribution, microbic virulence, and host susceptibility.Finally, on the basis of these studies, an hypothesis has been constructed to explain the spread of typhoid-like diseases in man and in animals. 3 This theory may be summarized as follows:The bacteria of enteric infection are widespread and may be found in the intestinal contents of many hosts.Strains differ markedly in pathogenicity but the inherent virulence or pathogenicity of any given strain is relatively a fixed quantity, not affected by animal passage.
Preclinical and clinical assessment of inhaled levodopa for OFF episodes in Parkinson’s disease
Authors: Michael M. Lipp, Richard Batycky, Jerome Moore, Mika Leinonen, Martin I. Freed
Journal: Science Translational Medicine (2016)

A levodopa powder delivered by a breath-actuated inhaler produced a rapid increase in plasma drug concentrations and improved motor function during OFF episodes in patients with Parkinson’s disease.
Distinct Functions of Senescence-Associated Immune Responses in Liver Tumor Surveillance and Tumor Progression
Authors: Tobias Eggert, Katharina Wolter, Juling Ji, Chi Ma, Tetyana Yevsa, Sabrina Klotz, José Medina-Echeverz, Thomas Longerich, Marshonna Forgues, Florian Reisinger, Mathias Heikenwalder, Xin Wei Wang, Lars Zender, Tim F. Greten
Journal: Cancer Cell (2016)
<i>MLH1</i>, <i>MSH2</i>, <i>MSH3</i> and <i>EXO1</i> polymorphisms and head and neck squamous cell carcinoma risk and prognosis.
Authors: Gustavo Jacob Lourenco, Guilherme Augusto Silva Nogueira, Camila Borges Martins Oliveira, Fernando Augusto Lima Marson, Leisa Lopes-Aguiar, Ericka Francislaine Dias Costa, Tathiane Regine Penna Lima, Vitor Teixeira Liutti, Frederico Leal, Vivian Antunes Santos, José Augusto Rinck, Carmen Silvia Passos Lima
Journal: Journal of Clinical Oncology (2015)

6063 Background: MLH1 c.-93G > A, MSH2 c.211+9C > G, MSH3 c.3133G > A, and EXO1 c.1765G > A polymorphisms have been associated with inefficient DNA mismatch repair (MMR). However, it is unknown whether they are involved with increased risk and prognosis of head and neck (HN) squamous cell carcinoma (SCC), therefore, this study aimed to clarify this issue. Methods: Genomic DNA from 450 HNSCC patients and 450 controls was analyzed by PCR-RFLP or real time PCR for discrimination of genotypes. The differences between groups were analyzed by χ2 or Fisher’s exact test. Multivariate analysis using the logistic regression model served to obtain age and tobacco status adjusted crude odds ratios with 95% confidence intervals (CI), and to assess the associations between genotypes and HNSCC. Relapse-free survival (RFS) and overall survival (OS) times were calculated using Kaplan-Meier estimate probabilities and differences between survival curves were analyzed by the log-rank test. The prognostic impact of genotypes was examined using univariate and multivariate Cox regression analyses. Results: MSH2 GG plus MSH3 GG (31.7% vs. 18.7%, P= 0.003) genotypes were higher in laryngeal SCC (LSCC) patients than in controls. Carriers of the respective combined genotype were under a 3.69 (95% CI: 1.54-8.81)-fold increased risk of LSCC. The median follow-up time of overall HNSCC patients enrolled in study was 46.0 months (1.6-166.0). At 60 months of follow-up, RFS was shorter in patients with EXO1 GG genotype (54.8% vs. 61.1%, P= 0.03) and OS was shorter in patients with MSH3 GG genotype (42.8% vs. 52.5%, P= 0.02) compared to those with other genotypes, respectively. After multivariate Cox analysis, patients with EXO1 GG and MSH3 GG genotypes had worst RFS (HR: 1.50, 95% CI: 1.03-2.20, P= 0.03) and OS (HR: 1.59, 95% CI: 1.19-2.13, P= 0.002) than those with the remaining genotypes, respectively. Conclusions: Our data present, for the first time, evidence that inherited MLH1 c.-93G > A, MSH2 c.211+9C > G, MSH3 c.3133G > A, and EXO1 c.1765G > A abnormalities of DNA MMR pathway are important determinants of HNSCC and predictors of patient outcomes. Our findings, once validated in additional studies, will contribute to personalize the therapy of HNSCC patients.
Multicenter study of the evaluation of eribulin (E) use in Sicily in metastatic breast cancer (MBC): A prospective registry (VESPRY trial).
Authors: Vincenzo Adamo, Giuseppina Ricciardi, Dario Giuffrida, Giuseppa Scandurra, Antonio Russo, Livio Blasi, Pietro Spadaro, Antonio Lucenti, Hector J. Soto Parra, Antonino Savarino, Francesco Ferraú, Filippo Zerilli, Francesco Verderame, Alfredo Butera, Veronica Franchina, Lorenzo Cottini, Guido Fedele, Michele Caruso
Journal: Journal of Clinical Oncology (2017)

e12565 Background: Eribulin Mesylate is a non taxane microtubule dynamics inhibitor, approved for heavily-pretreated MBC patients (pts). Methods: This is a multicenter, prospective, single arm study for E-treatment of third line in pretreated MBC pts, conducted in 14 oncology centers in Sicily. All pts had received two previous chemotherapy regimens for MBC. Pts received E at 1.23 mg/m 2 on days 1,8 every 3 weeks until progression. Primary Endpoints: overall response rate (ORR) according to the site of metastases and safety. Secondary objectives: Progression-free survival (PFS) and ORR according to different subtypes. PFS curve was estimated using the Kaplan-Meier method. Multivariable logistic regression model were used to evaluate the associations of each variables with tumor response. ORR was assessed according to RECIST 1.1 and safety with CTCAE v4.0. Results: 122 pts were enrolled and received at least 1 dose of E. Median age was 58 (range 29-79). All received previously anthracycline and taxane based-therapies. Subtypes: Luminal A 69%, Luminal B 7%, HER2 enriched 4% and Triple Negative 20%. The most common metastatic sites were bone and liver; 67% had metastatic disease involving two or more organs. A median of 5 cycles of E (range 1-26) was administrated. 106/122 pts were evaluable for efficacy, all for safety. ORR was 48%. Exploratory subset analysis showed significantly higher ORR in the lung, liver and bone lesions compared to other site of metastases and in HER2 negative pts. Multivariable regression model showed that HER2 positive subtype was correlated with a poor response (odd ratio 6.7, 95% CI 1.2-36.5). The median PFS was 14.7 months (mos) (95% CI 7.2–25.7). Among pts with &lt; 65 and ≥ 65 years, the median PFS was 14.7 and 25.7 mos, respectively. Most common toxicities: G2 diarrhea 1%, asthenia G1 4%, G2 neutropenia 6%, G1 neurotoxicity 5%, QT prolongation 1%, G4 mucositis in only one case. Conclusions: This study showed a significant improved of PFS with E in third line setting and a favorable safety profile compared with results reported in the pivotal trial. Our findings suggest that E has substantial antitumor activity when used early for the treatment for MBC with acceptable safety.
Hernia Mesh Repair and Global Surgery
Authors: Jessica Beard, Michael Ohene-Yeboah, Jenny Löfgren
Journal: JAMA Surgery (2016)

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Randomized Comparison of Imatinib 400 Mg Vs. Imatinib + IFN Vs. Imatinib + AraC Vs. Imatinib after IFN Vs. Imatinib 800 Mg: Optimized Treatment and Survival. Designed First Interim Analysis of the German CML Study IV
Authors: Ruediger Hehlmann, Susanne Saussele, Michael Lauseker, Ulrike Proetel, Elena Kovalevskaya, Armin Leitner, Claudia Haferlach, Brigitte Schlegelberger, Martin C Müller, Benjamin Hanfstein, Markus Pfirrmann, Gerhard Ehninger, Thomas Fischer, Joerg Hasford, Andreas Hochhaus, Dieter K. Hossfeld, Hans- Jochem Kolb, Stefan W Krause, Christoph Nerl, Hans Pralle, Alois Gratwohl, Andreas Tobler, Hermann Heimpel
Journal: Blood (2008)
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo
Authors: Petter S. Woll, Una Kjällquist, Onima Chowdhury, Helen Doolittle, David C. Wedge, Supat Thongjuea, Rikard Erlandsson, Mtakai Ngara, Kristina Anderson, Qiaolin Deng, Adam J. Mead, Laura Stenson, Alice Giustacchini, Sara Duarte, Eleni Giannoulatou, Stephen Taylor, Mohsen Karimi, Christian Scharenberg, Teresa Mortera-Blanco, Iain C. Macaulay, Sally-Ann Clark, Ingunn Dybedal, Dag Josefsen, Pierre Fenaux, Peter Hokland, Mette S. Holm, Mario Cazzola, Luca Malcovati, Sudhir Tauro, David Bowen, Jacqueline Boultwood, Andrea Pellagatti, John E. Pimanda, Ashwin Unnikrishnan, Paresh Vyas, Gudrun Göhring, Brigitte Schlegelberger, Magnus Tobiasson, Gunnar Kvalheim, Stefan N. Constantinescu, Claus Nerlov, Lars Nilsson, Peter J. Campbell, Rickard Sandberg, Elli Papaemmanuil, Eva Hellström-Lindberg, Sten Linnarsson, Sten Eirik W. Jacobsen
Journal: Cancer Cell (2015)
Genomic Landscape of CXCR4 Mutations in Waldenstrom's Macroglobulinemia
Authors: Stephanie Poulain, Christophe Roumier, Emmanuelle Doye, Martin Figeac, Aurélie Caillault, Sandrine Geffroy, Olivier Nibourel, Frederic Lepretre, Agnes Daudignon, Sabine Tricot, Patrick Duthilleul, Claude Preudhomme, Xavier Leleu
Journal: Blood (2014)
TCT-685 Results After Transcatheter Valve-in-Valve Implantation And Redo Aortic Valve Surgery For Failed Aortic Bioprostheses
Authors: Magdalena Erlebach, Michael Wottke, Marcus-André Deutsch, Markus Krane, Nicolo Piazza, Ruediger Lange, Sabine Bleiziffer
Journal: Journal of the American College of Cardiology (2015)