tbuckley/cabot-search huggingface dataset:
AB0392 Not Increased Cancer Frequency at Patients with Rheumatoid Arthritis During TNF Inhibitor Treatments: Hur-Bio Real Life Results: Table 1.
Authors: M. Torgutalp, S. Kilickap, H. Babaoglu, O. Karadag, L. Kilic, A. Erden, A. Akdogan, S.A. Bilgen, S. Kiraz, I. Ertenli, U. Kalyoncu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> There are still controversial data regarding the development of malignancy after TNF inhibitor (TNFi) therapy. <h3>Objectives</h3> The objective of this study was to assess whether TNFi increases the risk of cancer development in Turkish Rheumatoid Arthritis (RA) patients in a single center real life experience <h3>Methods</h3> HUR-BIO (Hacettepe University Rheumatology Biologic Registry) is a single center biological registry since 2005 that include 815 RA patients under biological treatments. Overall, 679 of 815 patients were treated with TNFi drugs. Collected data includes demographic data, co-morbidities, smoking, switch ratio, baseline and follow-up disease activity parameters. Malignancy history before TNFi drugs were recorded from local database. After TNFi exposure, malignancy data were obtained from local database, social security administration data and Republic of Turkey Ministry of Health data. Development of cancer was assessed by calculating 100 patient–year exposure. These results are compared with Turkey 2005 Cancer Data and standardized incidence ratio (SIR) were identified (1). SIR was calculated by multiplying the ratio between expected number of cancers and observed number of cancer by 100. <h3>Results</h3> The mean age of 679 RA (77.8% women) patients was 50.4 (13.1) years and total duration of TNFi was 1623 patient-years. Initial TNFi were adalimumab 223 (32.8%), etanercept 321 (47.3%), infliximab 115 (16.9%) and golimumab 20 (3.0%). Before TNFi drugs, 2 patients had malignancy history (one breast cancer and one prostate cancer). During follow-up period, 5 additional cancer were obtained (Table 1). SIR was calculated as 1.26 in patients with advanced malignancy after anti-TNF drugs (confidence interval could not be obtained because of the small sample size). <h3>Conclusions</h3> In this single center real life experience, the incidence of malignancy after TNFi drugs at RA patients probably remains within the confidence interval according to the healthy population. We did not have RA control groups with DMARDs, and this is the limitation of our study. <h3>References</h3> Haydaroğlu A et al. Türk Onkoloji Dergisi 2007;22:22-28. <h3>Disclosure of Interest</h3> None declared
Effects of Roentgen Eays on Cancer. I. Direct Microscopic Observations on Living Intraocular Transplants of Frog Carcinoma
Authors: Balduin Lucké, M. D., H. G. Schlumberger, M. D.
Journal: JNCI Journal of the National Cancer Institute (1950)

Journal Article Effects of Roentgen Eays on Cancer. I. Direct Microscopic Observations on Living Intraocular Transplants of Frog Carcinoma Get access Balduin Lucké, M. D., Balduin Lucké, M. D. Search for other works by this author on: Oxford Academic PubMed Google Scholar H. G. Schlumberger, M. D. H. G. Schlumberger, M. D. Department of Pathology, School of Medicine, Univeristy of Pennsylvania, Philadelphia 4, Pa., Department of Pathology, Ohio State University, Columbus 10, Ohio, and the Marine Biological Laboratory, Woods Hole, Mass. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 3, December 1950, Pages 511–543, https://doi.org/10.1093/jnci/11.3.511 Published: 01 December 1950 Article history Received: 13 October 1950 Published: 01 December 1950
Influence of age and relative weight on cortisol suppression in normal subjects
Authors: M F Weiner, B M Davis, R C Mohs, K L Davis
Journal: American Journal of Psychiatry (1987)

The authors examined the effects of certain nonpsychiatric variables on dexamethasone suppression test (DST) results. Sixty physically healthy, nondepressed, nondemented adults participated in a standard outpatient 1-mg DST. Postdexamethasone plasma cortisol concentrations were higher in older subjects and were lower in more obese subjects. The authors conclude that age and relative weight influence cortisol suppression in healthy subjects.
PWE-265 Laparoscopic versus open colectomy: which technique to use and when?
Authors: AS van Dalen, A Murray, U Ali, C Mauro, R Kiran
Journal: Gut (2015)

<h3>Introduction</h3> While the role of laparoscopic surgery (LC) for colorectal cancer (CRC) has evolved for use in the majority of instances, the ability to predict circumstances where it is associated with better or worse outcomes after colectomy will help guide surgeons in the relative choice of the procedure over open surgery (OC) particularly when dealing with patients expected to be at high risk for postoperative complications. This study examines factors that may guide the relative circumstances where either the laparoscopic approach may preferably be indicated or avoided. <h3>Method</h3> The National Surgical Quality Improvement Program 2012–2013 database was used to identify patients who underwent LC and OC for the treatment of CRC. First, the 2 surgical groups were compared using Mann Whitney U tests and Chi-square statistics. Next, the relationship between surgery type (LC vs. OC) and postoperative outcomes, classified as either medical or surgical complications, was examined using multivariable logistic models. Any covariates univariately associated with the outcome of interest (<i>P</i>value &lt;0.20) were controlled for in the multivariable model. Lastly, the interaction between each of these covariates and LC/OC was examined to identify risk factors that may make LC or OC more preferable. <h3>Results</h3> Of the 24502 patients who underwent surgery for CRC, 11866 (48.4%) underwent LC and 12636 (51.6%) underwent OC. There were significant differences in comorbidities between patients who underwent LC versus OC, with mean BMI, chronic steroid use and neurological disease as the only exceptions. OC patients were more likely to undergo emergency surgery, have ASA class 3/4 instead of ASA 1/2 and undergo proctectomy over colectomy than LC patients. Patients undergoing LC had a lower likelihood of developing any complication compared to OC. When evaluating factors associated with the occurrence of surgical complications, ASA class was the only common independent predictor (<i>P</i>value 0.02). LC was associated with lower complication rates for both ASA class 1/2 and 3/4 patients and was even found to be more protective for class 3/4 (OR 0.52 vs. 0.72). When evaluating the relative benefit of LC over OC concerning medical complications, neurological disease remained the only independent predictor (<i>P</i>value 0.02). Hence, patients with a history of neurological disease undergoing LC were more likely to develop medical complications (OR 1.3) compared to those without a neurological history (OR 0.57). <h3>Conclusion</h3> These data suggest that while OC is currently the preferred technique for patients with comorbid conditions, LC confers particular benefits in terms of surgical complications in CRC patients with the most significant comorbid conditions. <h3>Disclosure of interest</h3> None Declared.
Actions speak louder than words.
Authors: P R Walker
Journal: Journal of Clinical Oncology (1994)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1994.12.12.2769 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 7989957 Actions speak louder than words. P R WalkerxP R WalkerSearch for articles by this author https://doi.org/10.1200/JCO.1994.12.12.2769 PDF "Actions speak louder than words.." Journal of Clinical Oncology, 12(12), pp. 2769–2770© 1994 by American Society of Clinical Oncology
AB0653 Sarcoïdosis: Osteoarticular Involvement – 57 Cases
Authors: K. Echchilali, M. Benzakour, F.-Z. Alaoui, F. Arif, M. Moudatir, H. Elkabli
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Sarcoïdosis is a multisystem granulomatous disease in which multiple organs, including the locomotor system, may be involved. Osteoarticular manifestations of sarcoidosis may be specific or nonspecific. They may be the presenting feature or may occur late after onset, either isolated or combined with other clinical manifestations. <h3>Objectives</h3> The aim of this study was to describe the clinical and therapeutic features of the osteoarticular sarcoidosis in Moroccan patients <h3>Methods</h3> It was a monocentric study realized in internal medicine department over 30 years (January 1985- August 2014) and including 57 sarcoid patients with osteoarticular manifestations. The diagnosis was based on a set of arguments (clinical, biological and radiological) with at least one positive biopsy site <h3>Results</h3> 57 patients among 111 cases of sarcoïdosis had osteoarticular manifestations (prevalence: 53,35%). The female sex was predominant (52 women/5 men) with a mean age of 44 years (range: 25-49). Osteoaticular involvement revealed the disease in 8,1% of cases. Joint damage was the most frequent (91,22%) and was made inflammatory arthralgia (50,87%), Löfgren9s syndrome (7,01%), chronic polyarthritis (31,57%) and acute oligoarthritis (8,77%). Bone involvement revealed sarcoidosis in 2 cases and was noted in 15,78% of patients. 8 patients (14,03%) had dactylis with cystic lesions, osteitis, periosteitis or destructrice lesions. The jaw hypertrophy was noted in 1 case. Bone biopsy had revealed the sarcoidosis granuloma in 4 cases where it was performed. One of our patients had a clinical miopathy and two others combined an ankylosing spondyloarthritis. Treatment was based on the non -steroidal anti-inflammatory drugs, associated or not to hydroxychloroquine or methotrexate. Glucocorticoïds were prescribed in the bone involvement. The evolution was good in the most of our patients. <h3>Conclusions</h3> Sarcoïdosis is a granulomatous systemic disease potentially involving the locomotor system. It is characterized by arthralgia, oligoarthritis and polyarthritis. Osseous involvement is rare and primarily affects small and distal bones. Corticosteroids are commonly used to treat more serious cases, but may result in additional risks of osteoporosis. <h3>References</h3> W.C. Curr Opin Rheumatol 2010,22:85–90. Marc A. Judson, MD, Sem Respir Crit care Med 2007;28(1). <h3>Disclosure of Interest</h3> None declared
ECT-induced postictal delirium and electrode placement
Authors: I Leechuy, R Abrams, J Kohlhaas
Journal: American Journal of Psychiatry (1988)

The authors report eight instances of ECT-induced postictal (emergence) delirium that occurred after bilateral ECT, right unilateral ECT, or left unilateral ECT. They conclude that postictal delirium is a random phenomenon unrelated to lateralized hemispheric mechanisms.
ThioMabs: improving safety abd retaining efficacy of antibody drug conjugates
Authors: Jagath Reddy Junutula, Helga Raab, Sunil Bhakta, Karen Ervin, Kathryn Parsons, Suzanna Clark, Debra Dugger, Edward Ha, Sarajane Ross, Charles Eigenbrot, William Leach, William Mallet, Richard Vandlen, Paul Polakis, Mark Sliwkowski, Henry Lowman, Richard Scheller
Journal: Cancer Research (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

918 

Antibody drug conjugates (ADCs) are a promising technology for specifically targeting cytotoxic agents to tumor cells. The current method for preparation of ADCs involves the usage of either lysine residues or cysteine residues involved in inter-chain disulfide bonds. Either method results in a heterogeneous population and inconsistent preparation, thereby posing a manufacturing challenge to produce ADCs for therapeutic utility. We have developed a novel robust biochemical assay (PHESELECTOR) to screen reactive thiols on antibody surface with an objective of utilizing these thiol groups for site-specific conjugation of cytotoxic drugs. We have screened and identified several potential ThioMab variants to conjugate cytotoxic drugs to either light or heavy chain (Fab or Fc region). These ThioMabs can then be derivatized through the reactive thiol group of engineered cysteine to obtain ADCs with defined number of drugs (~2 drugs/ab). A number of ThioMab-ADCs were produced and tested in both efficacy and toxicity models. The efficacy of the ThioMab-ADCs is equal if not superior to ADCs produced by the conventional method. Surprisingly, the safety of these conjugates is considerably better than that observed with the conventional ADCs. Therefore, ThioMab technology provides a unique advantage over conventional ADCs to overcome unresolved manufacturing challenges and offers a solution to potential ADC toxicity issues.
AB0784 Conditions of Work Leading to Absenteeism in Spondyloarthritis Tunisian Patients
Authors: O. Saidane, L. Gafsi, I. Mahmoud, H. Sahli, R. Tekaya, L. Abdelmoula
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Spondyloarthritis (SA) is a chronic inflammatory disease affecting young and active patients and often affects their work productivity. <h3>Objectives</h3> To describe professional characteristics of Tunisian patients affected by SA and to determine work conditions that may expose to work productivity impairment. <h3>Methods</h3> We performed a cross-sectional monocentric study of 99 patients with SA recruited during 1 year at the Department of Rheumatology. Disease parameters and professional characteristics were recorded. Patients were asked if they have missed work time during the last three months because of their disease. For statistical analysis, we used Khi<sup>2</sup> -test, a p value ≤0.05 was considered significant. <h3>Results</h3> Eighty-three man and 16 women were included. Among these patients 65.6% were eligible to a professional activity (aged between 18 and 65 years and having ended their studies or vocational training). Their average age was 40.02 years ±11.7. Disease mean duration was 11.85±10.29 years. Mean BASFI score was 40.3% and mean BASDAI score was 42.3%. Manual labor has been noted in 55.4% and a hard physical work in 23.1%. Concerning the conditions of work, prolonged sitting was adopted in 44.6%; bad posture was adopted in 36.9% and 23.1% of cases were carrying heavy loads. Manipulation of vibrant engine was noted in 9.2% and work in cold environment in 32.3%. The mean number of working hours per day was 5.57±4 h and the mean day rest duration was 39min. Almost one third of patients (32.8%) accused having a stressful work and, while 29.2% judged that the day rest duration was insufficient. The mean distance between the place of work and home was of 4.7 km ±9.12 crossed at mean in 17 min using a means of transportation. Twenty-three percent of employees missed work time during the last three months because of their health condition. Statistical analysis showed that factors significantly associated with absenteeism were: high number of working hours (p=0.037), bad posture (0.001), stress at work (0.035) and insufficient day rest duration (0.007). Carrying heavy loads was more frequent in patients on sick leave but not statistically significant (p=0.076). Risk of absenteeism was independent of SA activity scores. <h3>Conclusions</h3> Absenteeism is frequent in SA Tunisian patients and it is essentially related to work conditions. High number of working hours, insufficient day rest duration, stress at work and bad postures are its predicting factors. <h3>Disclosure of Interest</h3> None declared
Diagnosis of Liver Diseases.
Authors: T TAKASUGI
Journal: Annals of Internal Medicine (1978)

d"Cn t^le vari?us diagnostic techniques used in patients with hepato-biliary ase.The translation is excellent.Each condition is described in terms of ctional changes, laparoscopy, hepatic histology and electron microscopy with, ere lndicated, vascular radiology and scanning procedures.Clinical findings are scanty and Often omitted and, of course, there is barely any mention of treat- ment-The lack of adequate discussion of immunological techniques such as serum niitochondrial antibody and the markers of hepatitis A and B infection is a draw- Th? emP^ias^s on serum enzyme tests, laparoscopy and histopathology.e book must, therefore, be read in conjunction with standard textbooks and ^ith reference to the original literature.Bibliography stops at 1976, and usually ^ delay citation is presumably related to the time taken to translate e book and to bring it from Stuttgart to London.Within these limitations the , .
Vitamin D–Binding Protein and Vitamin D in Blacks and Whites
Authors: Camille E Powe, S Ananth Karumanchi, Ravi Thadhani
Journal: New England Journal of Medicine (2014)

Powe et al. reported that black participants and white participants have different vitamin D requirements on the basis of the circulating concentration of vitamin D-binding protein.The authors used an assay for vitamin D-binding protein that is untested for the key measurement in their study.This assay is based on a primary monoclonal antibody produced against a single peptide fragment of the human vitamin D-binding protein.2][3] The problem is that the monoclonal-antibody assay gives lower values in blacks who have primarily the Gc1F variant of vitamin D-binding protein.The monoclonal antibody discriminates between the Gc1F and Gc1S variants to provide artificially low values for total vitamin D-binding protein in blacks, thus bringing the conclusion of this study into question.As shown in Figure S4 in the Supplementary Appendix (available with the full text of the article at NEJM.org), "calculated" concentrations of bio-available 25hydroxyvitamin D correlate well with physically measured concentrations in participants homozygous for either the Gc1F or Gc1S variant, but the slopes of the relationships are very different.Specifically, for any given physically measured level of bio-available 25hydroxyvitamin D, the authors are overestimating bio-available 25-hydroxyvitamin D by 2 to 2.5 times owing to underestimation of vitamin D-binding protein in blacks.
Use of the vaccination register to evaluate influenza vaccine coverage in seniors in the 2010/11 influenza season, Navarre, Spain
Authors: I Aguilar, M Reyes, I Martínez-Baz, M Guevara, E Albéniz, M J Belza, J Castilla
Journal: Eurosurveillance (2012)

Binary file ES_Abstracts_Final_ECDC.txt matches
Soundings: Deeply moving
Authors: Liam Farrell
Journal: BMJ (2001)

If a tree falls in the forest and no one is there to hear, does it make a sound? One of a doctor's unwritten roles is just to be there, to be a witness, a witness to pain and suffering, to grief and loss, to moments of great joy and great sorrow, but most of all a witness to body fluids.

Mrs Keogh arrived in the surgery in what P G Wodehouse would have called a dignified procession of one. “What do you think of that, doctor?” she asked, burping open the Tupperware container.

There followed a long, contemplative, and unexpectedly companionable silence; a golden, serene moment, a time for pause and quiet reflection, a time to stop and smell the flowers in a world that rushes ever faster. As the air grew steamy around us I could see little motes of dust sparkling in a stray gleam of sunlight through the window and hear far away in the distance a small aeroplane purring over the meadows. The surgery had the spiritual ambience of a monastery chapel, and if C S Lewis and J R R Tolkien had walked in twittering gently on about morality and suspiciously androgynous fairies I wouldn't have been surprised.

Eventually, and not without some feeling of loss, I surfaced. “That is a very impressive bowel motion, ma'am,” I said slowly, “a very impressive bowel motion indeed, the very opposite of jejune, the apotheosis of the gold bar; an unforgettable bouquet, lines as sleek as a thoroughbred racehorse, and a colour deep and mysterious as a Conrad novel. If it could talk it would have the rich, fruity timbre of Anthony Hopkins, and it would tell us of a digestive system in excellent, nay, in exquisite shape, bespeaking a diet rich in all the fine things of this goodly earth. If this were the Olympics, we could hang the medal round its finely tapered neck right now.”

But Mrs Keogh had yet another surprise for me. “It's not mine, it's my husband's,” she said, her voice soft with tenderness (was that a tear in her eye?). “Isn't it a beauty?”

Some married couples are just a little too close for comfort, I thought. “Love sees not with the eyes but with the mind/And thus is one eyed Cupid ever painted blind.”

“If you love something, let it go,” I paraphrased solemnly, “we'll bury the little lad at sea.”
Mutations of the E2F4 gene in hematological malignancies having microsatellite instability
Authors: Naoki Komatsu, Seisho Takeuchi, Takayuki Ikezoe, Taizo Tasaka, Yoshihiro Hatta, Hisanori Machida, Ian K. Williamson, Claus R. Bartram, H. Phillip Koeffler, Hirokuni Taguchi
Journal: Blood (2000)
Management of Ovarian Carcinoma
Authors: Jeffrey S. Tobias, C. Thomas Griffiths
Journal: New England Journal of Medicine (1976)

Despite many dramatic and rapid advances in the treatment of cancer during the last 20 years, the management of ovarian cancer remains unsatisfactory. Although surgical and radiotherapeutic technics have improved, the survival figures for ovarian cancer have not. The five-year survival rate has improved only from 29 per cent (1950–1959) to 32 per cent (1965–1969).1 At present, approximately 11,000 deaths occur from this disease in the United States each year, with a further 3000 deaths per annum in the United Kingdom.2 , 3 This figure represents a death rate greater than that for neoplasms of the cervix and corpus uteri combined. Since . . .
Recent developments in American psychiatry and Dr. Melvin Sabshin's contributions to them
Authors: M Nishizono
Journal: American Journal of Psychiatry (1997)

A "Dialogue" session was set up during the seventh scientific meeting of the Pacific Rim College of Psychiatrists in 1995. The objective of this session was to clarify the opinions of great scholars on modern psychiatry and their contributions to its development. Participants discussed characteristics of psychiatry in various countries as well as the future of world psychiatry. The following article is the "dialogue" that occurred between Professor Nishizono and Dr. Melvin Sabshin.
China’s One-Child Policy—In Reply
Authors: Therese Hesketh
Journal: JAMA (2016)

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