tbuckley/cabot-search huggingface dataset:
Soundings: Happy birthday, Ma'am
Authors: James Owen Drife
Journal: BMJ (2000)

The Queen Mother is patron of our royal college and we were among the 300-odd organisations invited to join a parade celebrating her 100th birthday. Envisaging something dignified, like Armistice Day, we decided that our council would process in academic robes, preceded by the college mace.

When the written briefing arrived, it sounded a different note. “Please bring a large sense of humour (you might need it) . . . There are a large number of animals in the parade including corgis, chickens, camels, and winkles.” All, apparently, “walking with a 23 inch pace at 112 paces a minute (so you have to get a move on).”

At the dress rehearsal we were marshalled by young guardsmen exuding effortless authority, even in green shirts and berets. “How will we know when to start?” I asked one. “Remember the sixties, sir,” he replied, without a flicker of irony, “and go with the flow.”

When the flow ended, Horse Guards Parade was full and all 5000 of us were being urged through a loudspeaker to march more quickly next time. As we looked around, we gained a deeper understanding of the British character. In mainland Europe there would be giant creations of papier mache. In South America there would be sexy costumes inspired by tropical birds. Here in England some of our neighbours were wearing knotted handkerchiefs and woolly jerseys.

After the rehearsal, sweltering in our robes, we had arranged to take tea and fruitcake in a quiet oasis in Pall Mall. We still had our official signboard saying “Royal College of Obstetricians and Gynaecologists,” and the only way to carry it through the thickening crowds of royal watchers was to hold it high. In the current climate of media opinion, we developed sudden misgivings.

The public's reaction was unexpected and reassuring. Some women smiled quietly before averting their eyes. One called out, “Thank you—I owe you so much.” One kissed a beaming past president. Then, as good humoured police stopped the traffic while we crossed the Mall, the spectators broke into a round of applause.

Two hours later, our brisk progress past the royal dais was upstaged by the Red Arrows. We called, “Hello, Ma'am,” as instructed in the briefing, and gave her a cheery wave, but everyone was gazing upwards. Happy birthday, anyway.
Rotavirus infection and histo-blood group antigens in the children hospitalized with diarrhoea in China
Authors: X. Sun, N. Guo, J. Li, X. Yan, Z. He, D. Li, M. Jin, G. Xie, L. Pang, Q. Zhang, N. Liu, Z.-J. Duan
Journal: Clinical Microbiology and Infection (2016)
Abstract 305: Single Cell RNA Sequencing of Adult Cardiac c-kit+ Cells in a Murine Lineage Tracing Model
Authors: Bryan D Maliken, Onur Kanisicak, Jeffery D Molkentin
Journal: Circulation Research (2015)

A subset of adult cardiac resident cells defined by the stem cell factor tyrosine kinase receptor termed c-kit, are believed to have myogenic potential and are now being delivered via intracoronary infusion to presumably promote cardiac regeneration and improve ventricular function after ischemic cardiac injury. However, recent studies have shown that despite these benefits, c-kit+ progenitor cells in the adult murine heart are more inclined to take on an endothelial rather than cardiomyocyte lineage. To better define the factors involved in early differentiation of these resident cardiac progenitor cells and to distinguish distinct cell subpopulations, we performed single cell RNA sequencing on c-kit+ cells from Kit-Cre lineage traced GFP reporter mice versus total mesenchymal cells from the heart that were CD31- and CD45-. Cells were isolated by cardiac digestion and FACS was performed, positively sorting for the c-kit+ lineage while negatively sorting for CD31 and CD45 to eliminate endothelial and leukocyte progenitor contamination, respectively. Following this isolation, cells were examined to determine GFP reporter status and then submitted for single cell RNA sequencing using the Fluidigm A1 system. Clustering of 654 genes from this data identified 6 distinct subpopulations indicating various stages of early differentiation among CD31- and CD45-negative cardiac interstitial cells. Furthermore, comparison of GFP+ c-kit cells to the total non-GFP mesenchymal cells identified 75 differentially expressed transcripts. These unique gene signatures may help parse the genes that underlie cellular plasticity in the heart and define the best molecular lineages for transdifferentiation into cardiac myocytes.
P-055 Prospective evaluation for chemotherapy-induced nausea and vomiting in colorectal cancer receiving oxaliplatin-based chemotherapy of moderate emetic risk
Authors: M. Shimokawa, T. Hayashi, T. Kogawa, R. Matsui, K. Suzuki, T. Saeki, K. Aiba, K. Tamura
Journal: Annals of Oncology (2016)
P-057 Body Composition (BC), beyond Body Mass Index (BMI) and sarcopenia, has a major prognostic impact on patients with refractory advanced Colorectal Cancer (aCRC)
Authors: C. Van Bogaert, C. Vandeputte, L. Ameye, M. Paesmans, T. Guiot, A. Deleporte, N. Charette, A. Hendlisz
Journal: Annals of Oncology (2016)
Efficient Termination of CD123-Redirected Chimeric Antigen Receptor T Cells for Acute Myeloid Leukemia to Mitigate Toxicity
Authors: Sarah K Tasian, Saad S Kenderian, Feng Shen, Yong Li, Marco Ruella, William C Fix, Miroslaw Kozlowski, Martin Carroll, Richard Aplenc, Carl H June, Stephan A Grupp, Saar I Gill
Journal: Blood (2015)
Case 32-1963
Authors: Gordon S. Myers, Robert E. Scully
Journal: New England Journal of Medicine (1963)

Presentation of CaseA sixty-six-year-old woman entered the hospital because of abdominal discomfort and cough.Two years before entry the patient had the sudden onset of dyspnea, ankle swelling, palpitation and discomfort in the chest. Digitalis and chlorothiazide caused some improvement and thereafter were taken erratically. Dyspnea after climbing one flight of stairs persisted, and orthopnea requiring two pillows and ankle swelling occurred on several occasions. There was no severe chest pain, hypertension, fainting or hemoptysis. Occasional episodes of epigastric discomfort occurred during the year before entry, and mild fatty-food intolerance had been present for several years. One week before . . .
Case 26-1972
Authors: W. Davies Sohier, Gerald Nash
Journal: New England Journal of Medicine (1972)

Presentation of CaseA 66-year-old woman was admitted to the hospital because of dyspnea.Nine months previously she noticed an enlarged left cervical lymph node, a biopsy of which two months later disclosed a tumor that was interpreted as either a reticulum-cell sarcoma or an undifferentiated carcinoma. An x-ray examination of the chest was reported to be negative. Six months before admission physical examination revealed enlarged lymph nodes in the cervical, supraclavicular and axillary regions bilaterally. The liver and spleen were not palpable. An x-ray film of the chest demonstrated fullness of the left superior mediastinum and left hilus; the . . .
A site-selective hyaluronan-interferonα2a conjugate for the treatment of ovarian cancer
Authors: Isabella Monia Montagner, Anna Merlo, Debora Carpanese, Anna Dalla Pietà, Anna Mero, Antonella Grigoletto, Arianna Loregian, Davide Renier, Monica Campisi, Paola Zanovello, Gianfranco Pasut, Antonio Rosato
Journal: Journal of Controlled Release (2016)

While interferon alpha (IFNα) is used in several viral and cancer contexts, its efficacy against ovarian cancer (OC) is far from being incontrovertibly demonstrated and, more importantly, is hindered by heavy systemic side effects. To overcome these issues, here we propose a strategy that allows a targeted delivery of the cytokine, by conjugating IFNα2a with an aldehyde-modified form of hyaluronic acid (HA). The resulting HA-IFNα2a bioconjugate was biochemically and biologically characterized. The conjugation with HA did not substantially modified both the antiviral function and the anti-proliferative activity of the cytokine. Moreover, the induction of STAT1 phosphorylation and of a specific gene expression signature in different targets was retained. In vivo optical imaging biodistribution showed that the i.p.-injected HA-IFNα2a persisted into the peritoneal cavity longer than IFNα2a without being toxic for intraperitoneal organs, thus potentially enhancing the loco-regional therapeutic effect. Indeed, in OC xenograft mouse models bioconjugate significantly improved survival as compared to the free cytokine. Overall, HA-IFNα2a bioconjugate disclosed an improved anticancer efficacy, and can be envisaged as a promising loco-regional treatment for OC.
Outcome of First-Line Treatment of Elderly Advanced Soft Tissue Sarcoma (Sts) Patients: a Pooled Analysis of Eleven Eortc Soft Tissue and Bone Sarcoma Group Trials
Authors: W.T.A. van der Graaf, A. Le Cesne, O. Mir, H. Gelderblom, A. Italiano, S. Marreaud, I. Judson, S. Litiere
Journal: Annals of Oncology (2014)
Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behçet's disease in Han Chinese
Authors: Hongsong Yu, Minming Zheng, Lijun Zhang, Hua Li, Yunyun Zhu, Ling Cheng, Lin Li, Bolin Deng, Aize Kijlstra, Peizeng Yang
Journal: Journal of Allergy and Clinical Immunology (2016)
Capgras syndrome in a patient with myxedema
Authors: S Madakasira, T B Hall
Journal: American Journal of Psychiatry (1981)

The authors describe what may be the first reported case of Capgras syndrome associate with, or precipitated by, myxedema. The patient's mental status dramatically returned to normal with gradual thyroid replacement. The authors suggest that tests for organicity be done routinely on patients manifesting Capgras features.
Influenza nucleoprotein DNA vaccination by a skin targeted, dry coated, densely packed microprojection array (Nanopatch) induces potent antibody and CD8 + T cell responses
Authors: Germain J.P. Fernando, Jin Zhang, Hwee-Ing Ng, Oscar L. Haigh, Sally R. Yukiko, Mark A.F. Kendall
Journal: Journal of Controlled Release (2016)
A brushfire in the eye
Authors: Mehnaz Khan, P Kumar Rao, Rajesh C Rao
Journal: BMJ (2016)

A 44 year old man with untreated HIV infection was referred to the department of ophthalmology for routine screening of ocular disease. He reported non-compliance with highly active antiretroviral therapy (HAART) consisting of efavirenz, tenofovir, and emtricitabine, and his CD4 count was below 50×106 cells/L. He had no ocular problems at the time of presentation to his general practitioner.

His visual acuity was normal. Examination of the anterior structures of both eyes was unremarkable. Examination of the right eye identified a white annular edge of haemorrhagic retinitis in a brushfire pattern (fig 1⇓). The fundus of the left eye looked normal.



Fig 1  Fundus photograph of the right eye on presentation showing a white, annular leading edge of retinitis (white arrows) associated with haemorrhage (blue arrow) in a brushfire pattern.



1.  What are the differential diagnoses for retinitis?

2.  What is the diagnosis?

3.  What is the most common cause of blindness in this condition?

4.  What are the available treatments and follow-up recommendations?

### 1. What are the differential diagnoses for retinitis?

#### Short answer

Retinitis can be secondary to viral, bacterial, fungal, and parasitic infections; autoimmune conditions; and cancer.

#### Discussion

The differential diagnoses include infections—viral (eg, herpes simplex virus (HSV), herpes zoster virus (VZV), cytomegalovirus (CMV)), bacterial (eg, syphilis and tuberculosis), parasitic (eg, toxoplasmosis and Toxocara canis ), and fungal (eg, candida) entities. Autoimmune diseases such as Behcet’s syndrome and cancers such as vitreoretinal lymphoma should also be considered. A complete medical history, as well as serological or intraocular fluid analysis (eg, polymerase chain reaction, fungal smear) can help narrow the diagnosis.

### 2. What is the diagnosis?

#### Short answer

Cytomegalovirus retinitis.

#### Discussion

Our case is a striking example of CMV retinitis with a “brushfire” pattern in an immunocompromised host. Although the diagnosis was largely based on clinical examination, polymerase chain reaction of biopsied intraocular fluid confirmed the presence of CMV.

Occasionally described as a “pizza pie,” “cheese and ketchup,” or “brushfire” retinitis, …
Case 1-1969
Authors: Guillermo C. Sanchez, Benjamin Castleman
Journal: New England Journal of Medicine (1969)

Presentation of CaseA fifty-three-year-old man was admitted to the hospital because of pain in the leg.For several years he had had hypertension, chronic atrial fibrillation and congestive heart failure, for which digoxin was prescribed. Two months before admission he entered another hospital because of acute confusion, without loss of consciousness or focal weakness. He conversed easily, although his memory was poor. Diabetes mellitus was found. An electroencephalogram was normal. After discharge the confusion persisted. Three weeks before entry he was readmitted to another hospital because of generalized weakness and unsteadiness of gait. The tendon reflexes were absent in . . .
Evaluation of depression, anxiety, and stress in nonmetastatic locally advanced head neck cancer patients: Prospective study in a tertiary medical center of India.
Authors: Koustav Mazumder, Shyamal Kumar Sarkar, Sudeshna Ray, Anindya Mukherjee
Journal: Journal of Clinical Oncology (2013)

e20707 Background: Head neck cancer is one of the prevalent cancers in India. The diagnosis, treatment and the treatment outcome affect various psychological issues of the patients. The aim of the study is to assess depression, anxiety and stress of locally advanced head neck cancer patients, receiving concurrent chemoradiation. Methods: It was a prospective study done in the department of Radiotherapy, Medical College &amp; Hospital, Kolkata from July 2012 to January 2013. Depression Anxiety Stress Scale (DASS) was used to assess the Depression, Anxiety and Stress of the locally advanced non metastatic head neck carcinoma patients. The assessment of the psychological factors was done by the DASS questionnaire in Bengali Version. Each patient was assessed by this scale after 1) breaking bad news, 2) 3 wks after starting the concurrent chemoradiation, 3) on completion of the treatment and 4) 6 weeks after completion ,assessing the response. In each time it was compared with the baseline values using paired t test. Results: Study was carried out with 45 locally advanced non metastatic head neck carcinoma patients. Among them majority are male (77.78%). It was seen that after “breaking bad news” 68.89% of patient are significantly depressed (p &lt; .05). Depression was more among Male population, having age less than 60 years. After 3 weeks of treatment and on completion - in both scenario depression decreased but anxiety and stress increased. There was a significant positive correlation between various toxicities (eg. Mucositis, Dysphagia) on Anxiety and Stress during the course of treatment. Depression after 6weeks on completion was significantly (p &lt; .05) depends on the type of response. Conclusions: The psychological factors of the patients suffering from locally advanced head neck cancer should be taken in consideration right after diagnosis, assessed regularly during the course of management and appropriate care may be taken accordingly.
Primary systemic CD30 (Ki-1)-positive anaplastic large cell lymphoma of the adult: sequential intensive treatment with the F-MACHOP regimen (+/- radiotherapy) and autologous bone marrow transplantation
Authors: R Fanin, F Silvestri, A Geromin, M Cerno, L Infanti, F Zaja, G Barillari, C Savignano, C Rinaldi, D Damiani, A Buffoli, F Biffoni, M Baccarini
Journal: Blood (1996)
Analysis of Somatic Changes in Human Tumor DNA Using Synthetic Oligonucleotide Probes
Authors: S Parimoo, B A Bachman, D Kumar, P W Nichols, R B Wallace, P Roy-Burman
Journal: Cancer Communications (1989)

Like most hematologic malignancies, solid cancers may be associated with non-random chromosomal abnormalities. Heterogeneity in the cell population in solid cancers and the chromosomal variations occurring among primary, explant, and passaged cells of a given tumor, however, present a major difficulty in assessment of their cytogenetic changes. Alternative approaches to identifying specific somatic changes in subtypes of solid cancers, without cell culture manipulations, must be developed. This report describes preliminary evidence indicating that oligonucleotide probes, homologous to short tandem repeats, that can determine individual identity, may also be useful tools with which to examine somatic changes in DNA which has been isolated directly from a tumor mass. Two, of the four, bladder tumors (transitional cell carcinomas) analyzed, exhibited oligonucleotide-based DNA fingerprint patterns that differed from those of corresponding constitutive or uninvolved tissue DNA. The changes that were observed included gain or loss of hypervariable DNA fragments or shifts in band intensities.
Bone Scan Index as an imaging biomarker to predict overall survival in the Zeus/SPCG11 study.
Authors: Mariana Reza, Manfred Wirth, Teuvo L. J. Tammela, Virgilio Cicalese, Francisco Gomez Veiga, Kurt Miller, Andrea Tubaro, Frans Debruyne, Anup Patel, Christien Caris, Wim Witjes, Ola Thorsson, Per Wollmer, Lars Edenbrandt, Mattias Ohlsson, Elin Tragardh, Anders Bjartell
Journal: Journal of Clinical Oncology (2016)

e16599 Background: The Zeus/SPCG11 study is a randomized controlled clinical trial with the aim to assess the efficacy of zoledronic acid (ZA) in preventing bone metastases in high-risk prostate cancer (PCa) patients. Bone Scan Index (BSI) reflects the tumour burden in bone calculated from bone scintigraphy, and has recently been validated as an imaging biomarker in metastatic PCa patients. The purpose of this study was to investigate if change in BSI during treatment may serve as a useful imaging biomarker to predict clinical outcome in the Zeus/SPCG11 study population. Methods: We retrospectively selected as our BSI-study cohort all patients with bone scan image data of sufficient quality to allow for both baseline and 48-months follow-up BSI-assessments. BSI data was obtained by using the automated quantification software EXINI boneBSI, in a blind fashion, without knowledge of any clinical data or treatment randomization. Clinical data on age, overall survival (OS) and prostate-specific antigen (PSA) concentration in blood at baseline and upon follow-up was collected separately. Association between clinical data and BSI change during treatment was evaluated using Cox proportional-hazards regression models, Kaplan-Meier estimates of the survival function and Log rank test. Discrimination between prognostic variables was assessed using the concordance index (C-index). Results: The 176 patients who fulfilled the inclusion criteria presented showed baseline characteristics similar to those of the final total Zeus/SPCG11 study population (N = 1,433)(p= 0.83). In our BSI-study cohort (N = 176), patients with a BSI change < 0.3 had a significantly longer median survival time compared to patients with BSI increase of > 0.3 (32.3 months and 18.2 months respectively) (p < 0.001). In the Cox analysis BSI change from baseline to follow-up was significantly associated with OS (p < 0.01 and C-index = 0.6) while age and PSA change were not significantly associated with OS. Conclusions: BSI change during treatment was associated with OS in high-risk PCa patients from the Zeus/SPCG11 study. BSI may be a useful imaging biomarker in future clinical trials involving PCa patients with bone metastases.
PD-001 Total cell-free DNA level in plasma as strong prognostic marker in metastatic colorectal cancer
Authors: K.-L. Spindler, C. Demuth, B. Soerensen, J. Johansen, D. Nielsen, N. Pallisgaard, E. Høgdall, P. Pfeiffer, M. Yilmaz, B. Jensen
Journal: Annals of Oncology (2016)
Factitious Hypokalemia
Authors: HOYLE LEIGH
Journal: Annals of Internal Medicine (1974)

Letters1 January 1974Factitious HypokalemiaHOYLE LEIGH, M.D.HOYLE LEIGH, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-80-1-111_2 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Most published reports of Munchausen's syndrome fall into one of three types originally described by Asher; acute abdominal, hemorrhagic, and neurologic (1-3). We here present an additional factitious symptom—hypokalemia. This may be a new type of Munchausen's syndrome, a "chemical type."A 22-year-old married white woman was admitted to the Yale-New Haven Hospital complaining of fatigue and "persistent hypokalemia," repeatedly documented at a local hospital, for which she had been treated with intravenous potassium. Several months before she had arrived at the emergency room in a comatose state, in cardiac arrest; she was immediately revived by intracardiac potassium...References1. ASHER R: Munchausen's syndrome. Lancet 260:339-341, 1951 CrossrefGoogle Scholar2. CHAPMAN J: Peregrinating problem patients—Munchausen's syndrome. JAMA 165:927-933, 1957 CrossrefMedlineGoogle Scholar3. CLARKEMELNICK ES: The Munchausen syndrome or the problem of hospital hoboes. Am J Med 25:6-12, 1958 CrossrefMedlineGoogle Scholar4. CRAMERGERSHBERGSTERN BMM: Munchausen syndrome. Its relationship to malingering, hysteria, and the physician-patient relationship. Arch Gen Psychiatry 24:573-578, 1971 CrossrefMedlineGoogle Scholar5. BAGAN M: Munchausen syndrome. Report of a case and a review of the literature. Boston Med Q 13:113-119, 1962 MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Department of Psychiatry School of Medicine Yale University New Haven, Connecticut PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTetany and Rhabdomyolysis Due to Surreptitious Furosemide — Importance of Magnesium SupplementationPseudo-Bartter's syndrome, diuretic abuse, idiopathic edema, and eating disordersLes maladies factices et le syndrome de MünchausenMeasurement of Urine Electrolytes: Clinical Significance and MethodsFactitious Bradycardia and Hypotension due to Surreptitious Ingestion of Propranolol 1 January 1974Volume 80, Issue 1Page: 111-112KeywordsComaEmergency departmentFallsFatigueHeartPotassium Issue Published: 1 January 1974 PDF downloadLoading ...
Life Events at the Onset of Bipolar Affective Illness
Authors: David L. Dunner, Vijayalakshmy Patrick, Ronald R. Fieve
Journal: American Journal of Psychiatry (1979)

The authors assessed the occurrence of stressful life events before the initial or subsequent episodes of affective illness in a group of 79 bipolar I manicdepressive patients who were attending a lithium clinic. About half of the patients recalled a life event in the 3-month interval before their initial episode; postpartum onset was prominent among these events. Few patients recalled life events for subsequent episodes. Finally, history data did not differentiate patients who recalled life events and those who did not. These data may be useful in assessing environmental antecedents of populations at risk for bipolar illness.