Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression
Authors: Alain Braillon, Jérémy Fonseca Das Neves, Francoise Taiebi
Journal: Annals of Internal Medicine (2016)

Letters20 September 2016Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major DepressionAlain Braillon, MD, PhD, Jérémy Fonseca Das Neves, MPsy, and Francoise Taiebi, MPsyAlain Braillon, MD, PhDFrom University Hospital, Amiens, France.Search for more papers by this author, Jérémy Fonseca Das Neves, MPsyFrom University Hospital, Amiens, France.Search for more papers by this author, and Francoise Taiebi, MPsyFrom University Hospital, Amiens, France.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0208 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Gartlehner and colleagues (1) conclude that cognitive behavioral therapy (CBT) and antidepressants “are both viable choices” because of their “similar efficacy.” This statement deserves comment. Safety cannot be ignored when choosing a treatment, and the U.S. Food and Drug Administration issued a black box warning in 2004 indicating that antidepressants were associated with an increased risk for suicidal thinking, feeling, and behavior in young persons.Furthermore, in other countries, clinical practice may differ because accessing psychotherapy remains a problem. For example, in France, the High Authority for Health issued a clinical practice guideline about depression in 2002 ...References1. Gartlehner G, Gaynes BN, Amick HR, Asher GN, Morgan LC, Coker-Schwimmer E, et al. Comparative benefits and harms of antidepressant, psychological, complementary, and exercise treatments for major depression: an evidence report for a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2016;164:331-41. [PMID: 26857743]. doi:10.7326/M15-1813 LinkGoogle Scholar2. Lépine JP, Briley M. The increasing burden of depression. Neuropsychiatr Dis Treat. 2011;7:3-7. [PMID: 21750622] doi:10.2147/NDT.S19617 CrossrefMedlineGoogle Scholar3. Summerfield D. Depression: epidemic or pseudo-epidemic? J R Soc Med. 2006;99:161-2. [PMID: 16508058] CrossrefMedlineGoogle Scholar4. Lustman PJ, Griffith LS, Freedland KE, Kissel SS, Clouse RE. Cognitive behavior therapy for depression in type 2 diabetes mellitus. A randomized, controlled trial. Ann Intern Med. 1998;129:613-21. [PMID: 9786808] LinkGoogle Scholar5. Wiles NJ, Thomas L, Turner N, Garfield K, Kounali D, Campbell J, et al. Long-term effectiveness and cost-effectiveness of cognitive behavioural therapy as an adjunct to pharmacotherapy for treatment-resistant depression in primary care: follow-up of the CoBalT randomised controlled trial. Lancet Psychiatry. 2016;3:137-44. [PMID: 26777773] doi:10.1016/S2215-0366(15)00495-2 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University Hospital, Amiens, France.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0208. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoComparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression: An Evidence Report for a Clinical Practice Guideline From the American College of Physicians Gerald Gartlehner , Bradley N. Gaynes , Halle R. Amick , Gary N. Asher , Laura C. Morgan , Emmanuel Coker-Schwimmer , Catherine Forneris , Erin Boland , Linda J. Lux , Susan Gaylord , Carla Bann , Christiane Barbara Pierl , and Kathleen N. Lohr Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression &Eacute;va Rásky and Sylvia Groth Comparative Benefits and Harms of Antidepressant, Psychological, Complementary, and Exercise Treatments for Major Depression Gerald Gartlehner , Bradley N. Gaynes , Catherine Forneris , and Kathleen N. Lohr Metrics 20 September 2016Volume 165, Issue 6Page: 453-454KeywordsAntidepressant drug therapyCognitive behavior therapyDisclosureExerciseFood and Drug AdministrationGlobal healthHealth insurancePsychologistsSafetyTreatment guidelines ePublished: 20 September 2016 Issue Published: 20 September 2016 Copyright & PermissionsCopyright © 2016 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...