tbuckley/cabot-search huggingface dataset:
Olaparib monotherapy in patients with advanced cancer and a germ-line <i>BRCA1/2</i> mutation: An open-label phase II study.
Authors: Bella Kaufman, Ronnie Shapira-Frommer, Rita K. Schmutzler, M. William Audeh, Michael Friedlander, Judith Balmaña, Gillian Mitchell, Georgeta Fried, Karin Bowen, Anitra Fielding, Susan M. Domchek
Journal: Journal of Clinical Oncology (2013)

11024 Background: The oral PARP inhibitor olaparib has shown antitumor activity as monotherapy in patients (pts) with breast and ovarian cancer with gBRCA1/2 mutations. This multicenter non-comparative study evaluated whether tumors in gBRCA1/2 mutation carriers are responsive to olaparib regardless of tumor type (NCT01078662). Methods: Heavily pretreated pts with advanced cancer refractory to standard therapy (98% of breast cancer pts had ≥3 lines of prior chemotherapy for metastatic disease) and with a gBRCA1/2 mutation, received olaparib 400 mg bid (capsule) until disease progression. Primary objective: tumor response by RECIST 1.1. Secondary objectives: PFS, OS and safety. Results: 298 pts received treatment and were evaluable. Enrollment is complete, 33 pts remain on study. Median duration of treatment in this heavily pretreated population was 5.5 months (range &lt;1–28.5 months). Most common AEs (generally grade 1/2) were fatigue (59%), nausea (59%) and vomiting (37%). Grade ≥3 AEs were reported for 162 pts (54%); most common was anemia (17%). 11 pts (4%) had AEs that led to treatment discontinuation. Conclusions: The observedtumor response rates indicate antitumor activity of olaparib monotherapy in gBRCA mutated pts with advanced cancer refractory to standard therapy. A clinical benefit was seen in prostate and pancreatic cancer and activity in ovarian and breast cancer was confirmed. Prolonged responses to olaparib across all tumor types support the hypothesis that therapy directed against a genetically-defined target has activity regardless of anatomic organ of origin. Olaparib was generally well tolerated with toxicities consistent with prior studies. Clinical trial information: NCT01078662. [Table: see text]
Changes in patients with gender-identity problems after parental death
Authors: S M Bernstein, B W Steiner, J T Glaister, C F Muir
Journal: American Journal of Psychiatry (1981)

The authors studied the incidence of parental loss among 163 gender-disordered patients and an equal number of psychiatric control patients. An unusually high number of gender-disordered patients had lost their fathers, particularly during adolescence and early adulthood. Many of these patients showed shifts in gender identity in the year after loss, and during that period many requested surgical sex reassignment for the first time. Changes in the patient's relationship with the remaining parent and experiences related to loss of the father are discussed.
An examination of the federal psychiatric training grant peer review process
Authors: C B Wilkinson, V I Reus
Journal: American Journal of Psychiatry (1977)

The authors present some of the criticisms that have been leveled against the federal peer review system of approving or disapproving monetary grants. They then summarize the process used by the National Institute of Mental Health's Psychiatry Education Branch to judge grant applications, focusing on the disposition of 527 applications reviewed in November 1974-January 1975. They found that the wide distribution of the reviewers by geography, subspecialty, experience, sex, and ethnicity, plus the steps taken to guard against bias and ensure fairness, were effective, refuting many of the criticisms of the group peer review process.
THU0485 High Costs for Health System of Misdiagnosing Osteoarthritis as Rheumatoid Arthritis
Authors: P. Santos-Moreno, G. Saavedra-Martinez, L. Villarreal, D. Gomez, J. Bello-Gualtero, V. Giraldo, P. Martinez, A. Sanchez, M. Sanchez, E. Uribe, M. Boon
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> There are an important number of patients with osteoarthritis (OA) that are misdiagnosed as rheumatoid arthritis (RA) in general practice in Colombia. They are treated as such with disease modifying anti-rheumatic drugs (DMARDs), leading to higher economic costs for health system. <h3>Objectives</h3> The aim of this study was to calculate the possible direct economic costs of the care of OA patients misdiagnosed as RA in a 36 month period in a cohort of patients derived to a specialized RA center in Colombia. <h3>Methods</h3> A descriptive cross sectional study was performed. Patients derived during a 36 month period to a RA specialized center with presumptive diagnosis of this disease and found finally diagnosed with OA were included in analysis. We described the direct costs in colombian pesos (COP) of their care assuming an average of 4 visits/year to general practitioner (8.400 COP/consultation), 2 visits/year for physiatrist and orthopedics (33.995 COP/consultation) and 4 set/year of conventional laboratories (92.161 COP/set). Cost of medication doses were calculated for an average use of methotrexate, sulfasalazine, chloroquine and prednisolone (39.620 COP/monthly). Indirect costs were not calculated. <h3>Results</h3> We found 1108 OA patients misdiagnosed as RA in a period of 36 months. For each patient we calculated 33.600 COP/year for general practitioner visits, 135.980 COP/year for specialized medicine visits, 368.644 COP/year for laboratory sets and 475.440 COP/year for medications. This leads to a total cost of 1.011.504 COP/year per patient. From a total of 1108 misdiagnosed patients the cost rises to 1.103.195.712 COP/year. These patients had an average of 4.5 years of wrong treatment for their misdiagnosis, making the cost rise up to 5.054.128.704 COP (2.641.990 million US dollars). <h3>Conclusions</h3> There is an important economic implication of the misdiagnosis of OA as RA, being this the most frequent mistake in the diagnosis of this disease. The implementation of educational programs for health care primary physicians and specialized RA centers could save this amount of money for the health system in Colombia. <h3>Disclosure of Interest</h3> None declared
FRI0060 Reliability of Musculoskeletal Ultrasound (MSK-US) in Rheumatoid Arthritis (RA) Multicenter Trials: Lessons Learned
Authors: Y. Suliman, V.K. Ranganath, M. Taylor, A. Ben-Artzi, C.P. Olmos, J. Brook, D. Elashoff, L. Ramrattan, G. Kaeley
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> MSK-US is widely used for assessing disease severity and response to therapy in RA clinical trials. Although reliability exercises have been published, there is sparse literature on standardizing numerous factors that may affect reliability. <h3>Objectives</h3> The aim of this study was to optimize MSK-US acquisition and scoring reliability prior to embarking on a multicenter MSK-US based RA study. <h3>Methods</h3> This two-site MSK-US study evaluated the following joints: bilateral radio-carpal, intercarpal, radioulnar, MCP 1-5, PIP 1-5, knees and MTP 2-5. The reliability among our two main ultrasonographers with &gt;5 years MSK-US experience was assessed in 3 phases (pre-face-to-face [pre-F2F], F2F, and post-F2F). A 1st draft MSK-US RA atlas was utilized as an initial reference for intensive teleconferences, which resulted in a 2nd draft atlas (images refined and scoring rules further delineated). <i>Pre-F2F:</i> The 2 ultrasonographers scored still images of 2 patients independently. Inter-reader reliability was calculated and most discrepant scores discussed. <i>F2F:</i> Each ultrasonographer scanned the same 6 patients independently, and then re-scanned 2 patients. The inter- and intra-reader reliability were calculated, and again discussion of most discrepant scores. Factors affecting discordance were identified and addressed: agreeing on cutoffs for synovitis scores, focal point positioning, positioning of deformed joints, room temperature, layer of gel used, prior familiarity with the machine, and color adjustment for PD to accommodate for color blindness (present is 7% of males and 0.5% in females). The 3rd and final atlas was developed as a reference for the post-F2F; clearly delineated the discrepancies among scores. <i>Post-F2F:</i> Each ultrasonographer rescored 2 patients9 scans acquired during F2F study. The intra- and inter-reader reliability was calculated using percent agreement, weighted-kappa, intraclass correlation coefficient (ICC), and spearman correlation. <h3>Results</h3> The F2F and post-F2F intra-reader reliability ranged between 79%_94% for exact agreement and 0.64-0.89 spearman correlation. The pre-F2F, F2F, and post-F2F inter-reader reliability ranged from 64-82% for exact agreement, 0.59-0.83 Spearman correlation (Tables 1&amp;2). Inter-reader reliability improved from pre-F2F (64% agreement and 0.77 spearman correlation) to post-F2F (82%agreement and 0.83 spearman correlation). <h3>Conclusions</h3> Our study highlights the importance of standardizing acquisition of MSK-US in RA clinical trials and provides practical tools to improve reliability. we recommend standardization of acquisition to be pursued, prior to commencement of multicenter MSK-US based RA trials. <h3>Disclosure of Interest</h3> None declared
Transplantability of a Canine Thyroid Carcinoma through Thirty Generations in Mixed-Breed Puppies&lt;xref ref-type="fn" rid="fn1"&gt;2&lt;/xref&gt;
Authors: Allam, M. W., Lombard, L. S., Stubbs, E. L., Shirer, J. F
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article Transplantability of a Canine Thyroid Carcinoma through Thirty Generations in Mixed-Breed Puppies Get access M. W. Allam, M. W. Allam School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Search for other works by this author on: Oxford Academic PubMed Google Scholar L. S. Lombard, L. S. Lombard School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Search for other works by this author on: Oxford Academic PubMed Google Scholar E. L. Stubbs, E. L. Stubbs School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Search for other works by this author on: Oxford Academic PubMed Google Scholar J. F Shirer J. F Shirer School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 17, Issue 2, August 1956, Pages 123–129, https://doi.org/10.1093/jnci/17.2.123 Published: 01 August 1956 Article history Received: 13 December 1955 Published: 01 August 1956
DDEL-15MANIPULATION OF THE BLOOD-BRAIN-BARRIER RESTORES THE EFFICACY OF MDM2 INHIBITION IN ORTHOTOPIC GLIOBLASTOMA MODELS
Authors: Daniel Ma, David Calligaris, Shuangling Zhang, Minjee Kim, Ann Mladek, Katrina Bakken, Brett Carlson, Mark Schroeder, Gaspar Kitange, Nathalie Agar, William Elmquist, Jann Sarkaria
Journal: Neuro-Oncology (2015)

BACKGROUND: Blood-brain barrier (BBB) integrity is heterogeneous in GBM, and controversy surrounds whether associated heterogeneous delivery may limit efficacy for otherwise highly active drugs. Using a MDM2-amplified patient-derived xenograft model, the small-molecule MDM2 inhibitor SAR405838 was tested for both heterotopic and orthotopic efficacy under BBB-intact and disrupted conditions. METHODS AND RESULTS: A panel of 55 patient-derived GBM xenograft lines was screened for MDM2 expression. Four p53 wild-type lines were selected for in vitro testing with SAR405838. Treatment with 100 nM of SAR405838 induced a significantly higher reduction in neurosphere formation for MDM2 over-expressed lines (GBM108, 143) when compared with lines without MDM2 over-expression (GBM10, 102). SAR405838 also profoundly suppressed flank tumor growth in GBM108 but not GBM102 during in vivo testing. GBM108 tumors regressed to undetectable and remained undetectable for over 3 weeks after cessation of therapy. In contrast to the profound efficacy observed in flank models, the identical SAR405838 dosing regimen was ineffective in GBM108 orthotopic tumors. The impact of the BBB was subsequently tested by over-expressing VEGFA in GBM108 via lentiviral transduction. Consistent with a leakier vasculature, orthotopic GBM108-VEGFA exhibited markedly more pronounced accumulation of Texas Red-3 kDa dextran and extent of contrast enhancement on magnetic resonance imaging when compared to GBM108-EV(empty-vector). Using MALDI-MS, SAR405838 delivery into orthotopic GBM108-VEGFA tumors was also found to be more homogeneous and significantly higher than corresponding GBM108-EV controls. Enhanced drug delivery in GBM108-VEGFA models translated into a marked enhancement in orthotopic treatment efficacy in comparison to GBM108-EV with a median survival prolongation of 37 vs 4 days (p = 0.0055.) CONCLUSIONS: SAR405838 provided remarkable efficacy in heterotopic but not orthotopic tumors. BBB disruption by VEGFA expression markedly enhanced drug delivery and treatment efficacy in orthotopic tumors, demonstrating the critical importance of BBB penetration for targeted therapies in gliomas.
Megakaryocytic Progenitors Can Be Generated Ex Vivo and Safely Administered to Autologous Peripheral Blood Progenitor Cell Transplant Recipients
Authors: Francesco Bertolini, Manuela Battaglia, Paolo Pedrazzoli, Gian Antonio Da Prada, Annalisa Lanza, Davide Soligo, Lorenza Caneva, Barbara Sarina, Scott Murphy, Terry Thomas, Gioacchino Robustelli della Cuna
Journal: Blood (1997)
Podophyllin in Treatment of Bladder Tumors
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Potential Plasma Substitute— 'As Effective As Dextran'
Authors: W L Thompson
Journal: JAMA (1966)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
PWE-307 A systematic review of local excision following neoadjuvant therapy for rectal cancer: are YPT0 tumours the limit?
Authors: DE Messenger, S Hallam, MG Thomas
Journal: Gut (2015)

<h3>Introduction</h3> Neoadjuvant chemoradiotherapy has been shown to reduce local recurrence following radical surgery for rectal cancer with contemporary studies reporting a complete pathological response of up to 30%. Radical surgery is associated with significant morbidity that may be avoided by local excision in selected cases. This systematic review aimed to determine the oncological outcomes of local excision following neoadjuvant therapy. <h3>Method</h3> A systematic search of the Medline, EMBASE and Cochrane Library databases was conducted to identify suitable articles. The search strategy captured terms for rectal cancer, neoadjuvant therapy and local excision. Outcomes are presented as weighted pooled proportions where appropriate. <h3>Results</h3> A total of 21 unique studies were included (one randomised controlled trial, four comparative cohort studies and 16 cohort studies) that described 1070 patients. The pre-treatment T-stage was cT1 in 2.4%, cT2 in 38.1%, borderline cT2/T3 in 2.7%, cT3 in 37.6%, cT4 in 0.1% and not specified in 19.6% of cases. Long course chemoradiotherapy was administered to 94.0% of patients and short course radiotherapy to 6.0%. Local excision techniques included transanal endoscopic microsurgery (53.7%), transanal excision (34.9%) and other approaches (11.4%). The pooled complete clinical response was 59.4% (95% confidence interval, 43.4% to 74.5%) and the pooled complete mural pathological response (ypT0) was 40.7% (95% CI, 33.6% to 47.9%). The median range of follow up was 38.2 months (range, 12 to 81 months). ypT0 tumours had a pooled local recurrence (LR) of 5.4% (95% CI, 2.8% to 8.7%) and a median disease free survival (DFS) of 90% (70% to 100%). The pooled LR and median DFS for ≥ypT1 tumours was 21.5% (95% CI, 14.8% to 29.0%) and 68.5% (58.3% to 100%), respectively. <h3>Conclusion</h3> Patients undergoing local excision with a complete mural pathological response had favourable oncological outcomes compared to those achieved with radical surgery. Given the unacceptably high rate of local recurrence among incomplete responders, future studies should focus on predicting those patients who will achieve a complete response. <h3>Disclosure of interest</h3> None Declared.
18F-FDG PET/CT Follow-up of Rosai-Dorfman Disease
Authors: Domenico Albano, Giovanni Bosio, Francesco Bertagna
Journal: Clinical Nuclear Medicine (2015)

Rosai-Dorfman disease (RDD) or sinus histiocytosis is a rare histiocytic disorder characterized by massive lymphadenopathy and with extranodal involvement in 25% to 43% of cases. The clinical course of RDD is unpredictable with episodes of exacerbation and remissions that can last many years, and treatment strategies can be different according to organ involvement. We report a case of a 42-year-old woman with extranodal disease followed for almost 10 years from the diagnosis who underwent seven 18F-FDG PET/CT. PET/CT has proven to be a useful method for the management of this patient, mainly for the staging, follow-up, and evaluation of treatment results.
Effect of Lymphoid Leukosis Virus Infection on the Cell-Mediated Immune Capacity of the Chicken2
Authors: David J. Granlund, Raymond W. Loan
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Effect of Lymphoid Leukosis Virus Infection on the Cell-Mediated Immune Capacity of the Chicken Get access David J. Granlund, David J. Granlund Search for other works by this author on: Oxford Academic PubMed Google Scholar Raymond W. Loan Raymond W. Loan Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 4, April 1974, Pages 1373–1374, https://doi.org/10.1093/jnci/52.4.1373 Published: 01 April 1974 Article history Received: 04 January 1974 Accepted: 22 January 1974 Published: 01 April 1974
Surgical controversies in melanoma.
Authors: C M Balch
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.2.392 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3339399 Surgical controversies in melanoma. C M BalchxC M BalchSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.2.392 PDF "Surgical controversies in melanoma.." Journal of Clinical Oncology, 6(2), pp. 392–393© 1988 by American Society of Clinical Oncology
Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1 (CD54) in tonsillar B cells and coordinate expression in follicular center B cells and in follicle center and mediastinal B-cell lymphomas
Authors: P Moller, C Henne, F Leithauser, A Eichelmann, A Schmidt, S Bruderlein, J Dhein, PH Krammer
Journal: Blood (1993)
Biliary ascariasis as etiology of recurrent abdominal pain
Authors: Rodrigo Mansilla-Vivar, Elizabeth Sainza Caballero, Cristina Saldaña Dueñas, Laura Casanova Ortiz, Ignacio Fernandez-Urien, Juan Vila Costas
Journal: Endoscopy (2016)

A 37-year-old woman had a history of cholelithiasis and choledocholithiasis in 2007, and cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy had been performed.
A follow-up investigation of offspring of parents with bipolar disorder
Authors: C Zahn-Waxler, A Mayfield, M Radke-Yarrow, D H McKnew, L Cytryn, Y B Davenport
Journal: American Journal of Psychiatry (1988)

Seven male children who each had a manic-depressive parent (five alos had a parent with unipolar depression) and 12 control children were studied. The proband children had shown a range of adjustment problems as infants and toddlers. Four years later, they continued to have substantial behavior problems, including ones that could be classified as DSM-III psychiatric diagnoses. On the basis of psychiatric interviews and psychological assessments, the proband children received more DSM-III diagnoses than the control children. Proband children reported internalizing symptoms; this pattern was corroborated by their mothers, who also characterized these children as showing antisocial behavior patterns.
Quality and Safety in Health Care, Part VIII
Authors: Jay A. Harolds, Laura Beth Harolds
Journal: Clinical Nuclear Medicine (2015)

Injuries from medication are common and often preventable. Fortunately, there are many steps that can be taken to increase medication safety. Adopting a culture of safety including more reporting of medication errors and thorough investigation of their causes, better training including medical and communication skills, adopting superior procedures, and enhanced utilization of technology are all very helpful in reducing adverse events from drugs. The nursing staff is an important line of protection against patient injury from drug errors. The final line of protection is the patient and the patient's family, so educating them about their medical condition, their medication regimen, and how to participate in the process of staying healthy is essential for medication safety.
Chromosomal Studies on Diethylstilbestrol-Induced Testicular Tumors in Mice&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: Hellström, K. E.
Journal: JNCI Journal of the National Cancer Institute (1961)

Journal Article Chromosomal Studies on Diethylstilbestrol-Induced Testicular Tumors in Mice Get access K. E. Hellström K. E. Hellström Institute for Tumor Biology, Karolinska Institutet Medical School, Stockholm, Sweden Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 26, Issue 3, March 1961, Pages 707–717, https://doi.org/10.1093/jnci/26.3.707 Published: 01 March 1961 Article history Received: 09 September 1960 Published: 01 March 1961