tbuckley/cabot-search huggingface dataset:
A Controlled Trial of Amantadine and Rimantadine in the Prophylaxis of Influenza a Infection
Authors: Raphael Dolin, Richard C. Reichman, H. Paul Madore, Raina Maynard, Pamela N. Linton, Joan Webber-Jones
Journal: New England Journal of Medicine (1982)

Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects of rimantadine and amantadine during an outbreak of influenza A. The subjects received drugs orally at a dose of 100 mg twice a day for six weeks. Influenza-like illness occurred in 41 per cent of the subjects receiving placebo but in only 14 per cent of those receiving rimantadine and 9 per cent of those receiving amantadine (P<0.001 for either drug vs. placebo). Laboratory-documented influenza occurred in 21 per cent of placebo recipients, 3 per cent of rimantadine recipients, and 2 per cent of amantadine recipients (P<0.001). These findings represent efficacy rates of 85 per cent for rimantadine and 91 per cent for amantadine, as compared with placebo. More recipients of amantadine (13 per cent) than recipients of rimantadine (6 per cent; P<0.05) or placebo (4 per cent; P<0.01) withdrew from the study because of Central-nervous-system side effects. On the basis of this study, rimantadine appears to be the drug of choice for the prophylaxis of influenza A. (N Engl J Med. 1982; 307: 580–4.)
Changes in the Blood Coagulation System Associated with Septicemia
Authors: James J. Corrigan, Walker L. Ray, Norma May
Journal: New England Journal of Medicine (1968)

Detailed coagulation analyses in 36 pediatric cases of septicemia revealed 22 gram-negative and eight gram-positive infections, two Rocky Mountain spotted fevers, and four with no etiologic agent isolated. Various changes in the clotting mechanism were encountered irrespective of the infectious agent but apparently related to blood pressure. The most frequent single abnormality was thrombocytopenia in 61 per cent of all cases. Multiple coagulation changes, regularly noted in patients with hypotension or shock, were interpreted as being secondary to diffuse intravascular coagulation. Similar changes were not seen in cases with normal blood pressures. The most reliable laboratory guides seemed to be a reduced platelet count, low factor V levels in plasma and fibrinolytic split products in serum. Heparin was given in all patients with hypotension suspected of having the defect. Most patients with septicemia and low blood pressure apparently have the defect.
WEIGHT LOSS BUT NOT EXERCISE LOWERS GLUCAGON RESPONSE AND IMPROVES GLUCAGON-LIKE PEPTIDE-1 TO INSULIN RATIO IN PREDIABETIC PATIENTS WITH CORONARY ARTERY DISEASE: THE RANDOMIZED CUT-IT TRIAL
Authors: Lene Roerholm Pedersen, Rasmus Olsen, Jens Juul Holst, Steen Bendix Haugaard, Eva Prescott
Journal: Journal of the American College of Cardiology (2015)
Abstract 2634: Combination of HSP90 and mTOR inhibition promotes pancreatic cancer growth inhibition
Authors: Colin D. Weekes, Madalina Ciobanu
Journal: Cancer Research (2010)

Abstract The molecular determinants of resistance to mTOR targeted therapies remain unspecified. Genomic analysis has demonstrated that a number of gene families promoting intracellular signal transduction are overexpressed in mTOR resistant human pancreas explant xenografts. Heat shock proteins serve as molecular chaperone for many of the proteins implicated in the analysis. As such, it was hypothesized that proximal intracellular signal transduction inhibition with a HSP90 inhibitor could overcome inherent pancreas cancer resistance to mTOR inhibitors. Fourteen human pancreatic cell lines have been analyzed with respect to their proliferative capacity upon exposure to RAD001 (mTOR inhibitor) and AUY922 (HSP90 inhibitor), both as single agents and in combination. In vitro analysis with CalcuSyn® software demonstrates synergistic antiproliferative effects of these two drugs. For example, combination index (CI) values ranging from 0.01 to 0.5 were observed when the mTOR resistant cell line PANC02.03 was treated with the combination of RAD001 and AUY922. In vivo treatment of the L3.6 xenograft model with AUY922 and RAD001 resulted in preferential tumor growth inhibition of the combination relative to either drug alone. These effects were associated with the inhibition of the pI3K/AKT/mTOR and the ERK pathways. In summary, proximal signal transduction inhibition by a HSP90 may overcome inherent pancreas cancer mTOR inhibitor resistance. Future work is designed to extend these finding and to determine the specific pathways that are necessary for the observed growth inhibition. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2634.
USO DE PRÓTESIS METÁLICAS EN ESTENOSIS DE LA ANASTOMOSIS BILIAR POSTRASPLANTE HEPÁTICO. EXPERIENCIA EN NUESTRO CENTRO
Authors: Y Arguedas Lázaro, T Revuelto Artigas, Y Ber Nieto, A Lué, P Lacarta García, J Ducons García, MA Simón Marco
Journal: Endoscopy (2012)

Introducción: Las complicaciones biliares son una de las complicaciones más frecuentes tras el trasplante hepático (TOH) llegando hasta el 11–25% de los pacientes y necesidad de retrasplante del 6–12,5%. La estenosis anastomótica se trata con CPRE con dilatación con balón de la zona estenótica y colocación posterior de una endoprótesis plástica, deben ser remplazadas cada 3meses durante un año. Objetivo: Describir el uso de prótesis metálicas en estenosis de la anastomosis biliar postrasplante hepático en nuestro centro. Método: Estudio descriptivo retrospectivo del uso de prótesis metálicas en patología biliar benigna colocadas en nuestro servicio desde noviembre 2009 a septiembre 2011. Resultados: Hemos recogido 18 casos, paciente TOH con estenosis de la anastomosis biliar, edad entre 35–68 años, 72% varones. El 16,7% presentaban además fuga biliar y 5,6% litiasis en hepático común. El 88,9% de los casos se han resuelto tras colocación de prótesis y 11,1% han requerido tratamiento quirúrgico. En el 18,8% se colocó como primera opción prótesis metálica, observándose en la primera revisión la resolución de la estenosis en el 75% de los casos y un 25% requirió recambio resolviéndose la estenosis con esta segunda prótesis. Al 81,2% se colocó prótesis plástica y el 100% requirieron recambios de prótesis con colocación de prótesis metálica, de estos el 14,3% requirieron tratamiento quirúrgico. Las complicaciones observadas tras la colocación de prótesis metálicas son las siguientes: 11,1% obstrucción de la prótesis por litiasis biliar, 16,7% migración de la prótesis, 5,6% sangrado leve y 5,6% imposibilidad de extraer la prótesis que se retiró en un segundo tiempo mediante CPRE; no se dieron complicaciones graves. Conclusiones: El uso de prótesis metálicas como primera opción en patología biliar benigna como son las estenosis de anastomosis biliar en el trasplantado hepático parece una opción terapéutica eficaz con escasas complicaciones. Sería necesario realizar estudios analíticos y de coste-efectividad para generalizar su uso.
Abstract 1446: Effect of PF-03475952, a potent and neutralizing CD44 antibody, on cancer cell apoptosis in vitro and metastasis in two orthotopic models
Authors: Yuli Wang, Jean Wang, Gary Li, Amy Jackson-Fisher, Simmons Brett, Eugenia Kraynov, Baiyong Li, David Pocalyko
Journal: Cancer Research (2010)

Abstract Effect of PF-03475952, a potent and neutralizing CD44 antibody, on cancer cell apoptosis in vitro and metastasis in two orthotopic models Yuli Wang, Jean wang, Gary Li, Amy Jackson-Fisher, Brett Simmons, Eugenia Kraynov, Christy Ji, Baiyong Li, and David Pocalyko Pfizer Global Research &amp; Development, San Diego, CA 92121 CD44 is a cell surface glycoprotein that has multiple functions. It can act as a receptor for ligands such as hyaluronic acid and osteopontin. Additionally, it can function as co-receptor to modulate the activation of growth factor receptors such as c-met &amp; ERBB. CD44 can also influence cell signaling through interaction with components of the actin cytoskeleton such as the ERM protein. CD44 expression is increased in many types of human cancer. It is also a cell surface marker for cancer stem cells in breast cancer and HCC. In HCC, CD44 overexpression is a frequent event (∼30% based on several reports) and CD44 up regulation is associated with metastasis and poor patient survival. Down regulation of CD44 with RNAi knockdown or neutralizing antibody has been reported to reduce tumor metastasis, recurrence, and growth in different models. PF-03475952 is a fully human IgG2 anti-CD44 monoclonal antibody that was initially developed as a potential therapeutic agent for rheumatoid arthritis. It was shown previously that the PF-03475952 can disrupt the interaction of CD44 with its ligand, hyaluronic acid. The antibody binding induces loss of CD44 from the cell surface, and inhibits LPS-induced cytokine release from various leukocytes. In this report, we evaluated the potential of PF-03475952 as a cancer adjuvant therapy for HCC. HCC is the third most deadly forms of cancer world-wide with frequent early recurrence due to inter and extra hepatic metastasis. The effect of PF-03475952 on cancer metastasis was first demonstrated in an M24met melanoma model. The expression of CD44 and the effects of PF-03475952 on HCC cell lines were then characterized. In vitro, PF-03475952 was able to reduce cell adhesion and promote apoptosis in a CD44-dependent manner. More importantly, PF-03475952 can reduce lung metastasis in a CD44-positive HCC orthotopic model. The study suggested that the CD44 neutralizing antibody, PF-03475952, could be an efficacious agent as adjuvant therapy to prevent cancer metastasis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1446.
Mucosectomie endoscopique en ambulatoire: est-ce possible? Est-ce raisonnable?
Authors: S Tarabichi, R Coriat, S Leblanc, F Prat, B Terris, S Chaussade
Journal: Endoscopy (2011)

Introduction: La mucosectomie endoscopique est un geste de plus en plus pratiqué pour la résection des lésions planes ou sessiles du colon avec un taux de complications faible (hémorragies, perforation...) variant de 2 à 5%. Classiquement les facteurs de risques de ces complications sont la taille du polype, son siège dans le colon droit, l'existence de comorbidités, la prise de certains médicaments (aspirine, AINS, AVK...) et un trouble de l'hémostase.
S162 Job categories and risk of adult onset asthma in the 1958 birth cohort from age 16 to age 42 years
Authors: R. Ghosh, P. Cullinan, D. Strachan, D. Jarvis
Journal: Thorax (2010)

<h3>Introduction</h3> Exposures in the workplace may cause adult onset asthma. In this analysis, we present the prevalence of ever working in job categories and the associated risks of adult onset asthma by age 42 in participants in the 1958 birth cohort. <h3>Methods</h3> All persons born in the first week of March in Britain in 1958 were recruited into the cohort. By age 42 9890 cohort members had provided a full occupational history and health information. Job titles and descriptions were initially coded into Standard Occupational Classification 1990 (SOC-90) using a text based computer program. Blind to asthma status we have recoded these jobs into the International Standard Classification of Occupations 1988 (ISCO-88) codes. The prevalence of ever working in jobs defined by these codes was determined. Adult onset asthma was defined as reporting ‘ever asthma’ at ages 33 or 42 and excluding all those who reporting ‘ever asthma’ at ages 11 or 16 (childhood asthma). The risk of adult onset asthma associated with these job categories was determined in logistic regression analysis adjusted for sex, smoking, region and father9s social class at birth. The Simes procedure was used to correct for multiple testing. <h3>Results</h3> After excluding childhood asthma the sample consisted of 8358 cohort members with a 9% prevalence of adult onset asthma. The most common jobs with the greatest risks of adult onset asthma are tabulated. <h3>Conclusion</h3> Several job categories were associated with adult onset asthma by age 42 in this cohort of adults born in 1958. This analysis confirms in a British population existing knowledge about occupations associated with the development of asthma in working life, and in particular shows consistent evidence of asthma development in those who have ever worked as a cleaner.
Epidemiology of pertussis in Italy: Disease trends over the last century
Authors: M V Gonfiantini, E Carloni, F Gesualdo, E Pandolfi, E Agricola, E Rizzuto, S Iannazzo, M L Ciofi Degli Atti, A Villani, A  E Tozzi
Journal: Eurosurveillance (2014)

Binary file ES_Abstracts_Final_ECDC.txt matches
Abstract LB-245: Nuclear translocation of HO-1 in prostate cancer. Role beyond heme degradation
Authors: Geraldine Gueron, Mercedes Ferrando, Belen Elguero, Angeles Salles, Roberto Meiss, Lucas Colombo, Alejandro Curino, Maria Marta Facchinetti, Nora Navone, Adriana De Siervi, Elba Vazquez
Journal: Cancer Research (2010)

Abstract Prostate cancer (PCa) is the second leading cause of cancer-associated death in men. The metastatic spread of PCa cells and the ability to survive when reaching the metastatic nitch is affected by growth factors, chemokines, angiogenic factors and hormones. Heme oxygenase-1 (HO-1), the inducible isoform of the rate-limiting enzyme in heme degradation, counteracts oxidative and inflammatory damage. Here we investigated its nuclear translocation in androgen sensitive (MDAPCa2b and LNCaP) and insensitive (PC3) PCa cell lines. Our results show that endogenous levels of HO-1 are markedly lower in PC3 compared to MDAPCa2b and LNCaP. Hemin treatment, a potent and specific inducer of HO-1, increased protein levels with a resulting nuclear translocation in PCa cell lines. Stable transfection of HO-1 in PC3 (PC3HO-1) also showed a significant nuclear translocation. Furthermore, human prostate cancer PC3HO-1 cells growing subcutaneously in athymic nude mice showed significant HO-1 nuclear staining (detected by immunohistochemsitry and immunofluorescence) compared to PC3pcDNA3 xenografts. Using RT-qPCR-generated gene array we observed a set of inflammatory and angiogenic genes up- or down-regulated in response to HO-1 overexpression, identifying VEGFA as a novel downstream target of HO-1. HO-1 modulation limited the metastatic potential of neoplastic cells by down-regulating VEGFA production. An in vivo angiogenic assay also demonstrated that PC3HO-1 tumors presented less neovascularization than tumors derived from control cells, giving further evidence to support HO-1 anti-angiogenic function. These results implicate for the first time HO-1 in the regulation of key proinflammatory factors, involved in PCa progression. Taken together our results suggest that HO-1 may be a potential target for therapeutic interventions. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr LB-245.
Collateral Resistance to Verapamil in Multidrug-Resistant Mouse Tumor Cells
Authors: J. G. REEVE, K. A. WRIGHT, P. H. RABBITTS, P. R. TWENTYMAN, G. KOCH
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Collateral Resistance to Verapamil in Multidrug-Resistant Mouse Tumor Cells Get access JULIE G. REEVE, JULIE G. REEVE Clinical Oncology and Radiotherapeutics UnitHills Rd. Cambridge CB2 2QH, England Search for other works by this author on: Oxford Academic PubMed Google Scholar KAREN A. WRIGHT, KAREN A. WRIGHT Clinical Oncology and Radiotherapeutics UnitHills Rd. Cambridge CB2 2QH, England Search for other works by this author on: Oxford Academic PubMed Google Scholar PAMELA H. RABBITTS, PAMELA H. RABBITTS Clinical Oncology and Radiotherapeutics UnitHills Rd. Cambridge CB2 2QH, England Search for other works by this author on: Oxford Academic PubMed Google Scholar PETER R. TWENTYMAN, PETER R. TWENTYMAN Clinical Oncology and Radiotherapeutics UnitHills Rd. Cambridge CB2 2QH, England Search for other works by this author on: Oxford Academic PubMed Google Scholar GORDON KOCH GORDON KOCH Laboratory of Molecular Biology, Medical Research Council CentreHills Rd. Cambridge CB2 2QH, England Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 20, 18 October 1989, Pages 1588–1590, https://doi.org/10.1093/jnci/81.20.1588 Published: 18 October 1989
AB1156 Relationship between smoking, clinical activity and functional impairment in ankylosing spondylitis patients:
Authors: I. Bouaddi, H. Rkain, I. Hmamouchi, D. Elbadri, F. Allali, N. Hajjaj
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> The aim of our study was to research eventual relationship betwen smoking, clinical activity and functional impairment in ankylosing spondylitis moroccan patients. <h3>Methods</h3> In this cross sectional study 210 patients with back pain and limited movements, diagnosed with AS based on clinical, radiological, and laboratory examinations were included in this study. Patients were divided in 2 groups, 47 smokers and 163 none. The 2 groups were apparied for age and disease duration. Disease activity was evaluated with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and functional impairment with the Bath Ankylosing Spondylitis Functional Index (BASFI). Analysis of association between and clinical activity and functional impairment was effected by T student. <h3>Results</h3> The mean of EVA pain, BASDAI, BASFI, ESR and C reactive protein was respectively 43±25.3, 4.6±2.7, 4.17±1.99, 10.2±12.4 and 20±19.75 In univariate analysis, there was no significant association between smoking and the activity or the functional impact of the disease respectively (p=0.4 and p=0.3). <h3>Conclusions</h3> This study suggests that smoking status in AS moroccan patients seems to be not associated with clinical activity and functional impairment <h3>Disclosure of Interest</h3> None Declared
Caregiver's Reported Prevalence of Symptom and Psychosocial Problem in Children with Allergic Rhinitis in South Korea
Authors: Sun-Hee Choi, Hyun Hee Kim, Young Yull Y. Koh, Yong-Mean Park, Man-Yong Han, Hye Young Yum, Yeong-Ho Rha
Journal: Journal of Allergy and Clinical Immunology (2013)
Abstract 5251: Branching morphogenesis in the mammary gland is regulated by sprouty-2
Authors: Valgardur Sigurdsson, Saevar Ingthorsson, Bylgja Hilmarsdottir, Sigridur R. Franzdottir, Eirikur Steingrimsson, Magnus K. Magnusson, Thorarinn Gudjonsson
Journal: Cancer Research (2012)

Abstract Branching morphogenesis is a conserved mechanism used by many species for organogenesis and tissue maintenance. Receptor tyrosine kinases (RTKs), including the epidermal growth factor receptor (EGFR), and their intracellular regulators, the sprouty protein family is believed to be a critical regulator of branching morphogenesis. In this study, we show that, Sprouty-2 (Spry-2) is predominantly expressed in the luminal epithelial cells both in ducts and lobuli in the human breast gland. We have also analyzed the expression of Spry-2 and EGFR pathway in virgin, lactating and pregnant mouse mammary gland. Spry-2 is expressed at branching epithelial buds during pregnancy with increased expression during lactation. The expression of phosphorylated EGFR (Y1068) shows a similar expression pattern as Spry-2. Using D492 a breast epithelial cell line with stem cell properties, that generate branching structures in 3D laminin rich gel we show that Spry-2 expression increases during the formation of branching. Immunostaining locates expression of Spry-2 and active EGFR at the tip of lobular-like, branching ends. Interestingly, knocking down (KD) spry-2 expression using shRNA resulted in increased migration. Spry-2 knockdown also gives larger and more complex branching structures indicating loss of negative feedback control of branching morphogenesis. In co-culture with endothelial cells, D492 spry-2 KD cells generate predominantly spindle like colonies reminiscent of epithelial to mesenchymal tansition. In conclusion, these data indicate that Spry-2 is an important regulator of branching morphogenesis and dysregulation of sprouty expression can lead to aberrant development related to breast cancer, such as epithelial to mesenchymal transition in the mammary gland. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5251. doi:1538-7445.AM2012-5251
WAIST CIRCUMFERENCE VERSUS OTHER OBESITY INDICES AS PROGNOSTICATORS OF CORONARY ARTERY DISEASE IN ESSENTIAL HYPERTENSION
Authors: Konstantinos P. Tsioufis, Kyriakos Dimitriadis, Alexandros Kasiakogias, Theodoros Kalos, Dimitris Konstantinidis, Georgios Georgiopoulos, Costas Thomopoulos, Dimitris Tsiachris, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2016)
Massive Resection and Allograft Transplantation in the Treatment of Malignant Bone Tumors
Authors: Henry J. Mankin, Frederick S. Fogelson, Antra Zarins Thrasher, Farooq Jaffer
Journal: New England Journal of Medicine (1976)

Nineteen massive resections and allograft transplantations have been performed for malignant or aggressive bone tumors. Allograft procurement technic uses freezing of the segment to decrease immunogenicity of the bony portion and glycinerization of the cartilage to maintain chondrocyte viability during freezing and thawing. Fifteen of the patients have been followed for an average of almost two years and were evaluated for early results by serial follow-up studies, including clinical, laboratory, x-ray and scan data. Despite numerous complications (related to both tumor and operation) none have metastases, local recurrence, or major functional impairment except for two whose grafts became infected. We conclude that, although still experimental, allograft replacement may in the future serve as an important approach to certain neoplastic conditions of bones and joints. (N Engl J Med 294:1247–1255, 1976)
Political Tug-of-War and Pediatric Residency Funding
Authors: Charlene A. Wong, Jeremiah C. Davis, David A. Asch, Richard P. Shugerman
Journal: New England Journal of Medicine (2013)

The recent government shutdown led to effective defunding of the Children's Hospitals Graduate Medical Education (CHGME) Payment Program. The funding lapse highlights the danger of subjecting GME funding to a politicized process.
Two-step removal of a migrated double-layered stent through a neoplastic stenosis using another double-layered stent and endoloops
Authors: F. Sábado, J. Pitarch, A. Bolós, B. Castelló, A. Peris
Journal: Endoscopy (2013)

Double layered self-expanding metal stents (SEMSs) are an effective treatment when placed across the gastroesophageal junction for malignant esophageal obstructions. The double layer provides effective prevention of stent migration, with the advantages of a covered stent [1]. However, should the stent migrate, the double layer makes endoscopic removal more difficult.