tbuckley/cabot-search huggingface dataset:
Understanding disease progression and treatment patterns in metastatic breast, colorectal, and lung cancer: Implications for evaluating value and quality of care.
Authors: Nicole M. Engel-Nitz, Stacey DaCosta Byfield, Timothy Bancroft, Amy J Anderson, Carolina M. Reyes, Arliene Ravelo, Sarika Ogale, Matthew J. Matasar, May C. Chen
Journal: Journal of Clinical Oncology (2016)

24 Background: Impact of strategies for evaluating value and quality of cancer care may vary for patients with metastatic tumors, particularly for strategies considering lines of treatment therapy as distinct events. To aid in evaluating the value and quality of care in patients’ overall trajectory of disease, this study examined disease progression, mortality, hospice, and treatment patterns in patients (pts) with metastatic breast (mBC), lung (mLC), and colorectal cancers (mCRC). Methods: Included were commercially insured and Medicare Advantage adults from a large US health plan administrative claims database (2007-2014); pts had ≥ 2 claims for BC, CRC, or LC, and ≥ 2 claims for metastases. Index date was defined as the first post-metastatic systemic anti-cancer therapy (TX). Health plan enrollment for 6 mo pre- and post-index date was required; pts with &lt; 6 mo of follow-up due to death were included. Pts with other primary cancers were excluded. A line of therapy (LOT) algorithm was developed and outcomes assessed over a variable follow-up. Progressive disease (PD) was defined as: start of a new LOT, where 1) previous LOT duration &gt; 60 days, and 2) ≥ 1 imaging/lab test occurred between previous LOT and new LOT; receipt of hospice care; or death. Results: Among 7070 mBC, 4767 mCRC and 6994 mLC patients, 73%, 72%, and 84% respectively progressed during the study period (incidence rates: 7, 7, and 13 per 10-pt-years). Mean (median) time in months to PD was 9.5 (6.5) for mBC, 9.0 (7.0) for mCRC and 6.3 (5.0) for mLC. For all cancers, median number of LOT over 1 year was 2, with means of 1.8 (mBC), 1.7 (mCRC), and 1.7 (mLC). Compared to patients without PD, patients with PD had shorter LOT1. Mortality was highest among mLC patients (50%) compared to mCRC (27%) and mBC (22%), with rates per 100-pt-years of 50, 16, and 11 respectively. Hospice rates varied by tumor type. Conclusions: The high level of progression and use of multiple lines of therapy in the metastatic setting suggests a need to delay progression with effective treatments for breast, lung, and colorectal cancers. The value and quality of cancer care should be evaluated across the entire span of patients’ disease.
D3-07: SNP of Phospholipase D1 gene as a Predictive Marker for Response to Chemotherapy in Non-small Cell Lung Cancer
Authors: Shin-Young Park, Myung-Ju Ahn, Ju Wan Cho, Hye Sook Lee, Keunchil Park, Joong-Soo Han
Journal: Journal of Thoracic Oncology (2007)
Who Writes the Right Prescriptions?
Authors: E.J. H.
Journal: Annals of Internal Medicine (1972)

Editorials1 April 1972Who Writes the Right Prescriptions?E.J. H.E.J. H.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-76-4-663 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn the first article of this issue Stolley and his associates describe their study of the relative prescribing of drugs, by major classes, in a large population through a 1-year period. Their data, although not surprising, merit the attention of prescribing physicians. Of almost 200 000 prescriptions issued in 1968 to patients in a population of 112 000, antibiotics were the leading class of drugs prescribed, at a rate double that for the next class, tranquilizers. This fact could be interpreted to imply that, in the area under study, antibiotics were prescribed unnecessarily in most cases, with an excessive risk...References1. MARONDELEEMCCARRON RPM: A study of prescribing patterns. Med Care 9:383-395, 1971 CrossrefMedlineGoogle Scholar2. ANON : Propoxyphene hydrochloride (Darvon) and Darvon compounds. Med Lett Drugs Ther 12:5-6, 1970 MedlineGoogle Scholar3. VANDAM L: Analgetic drugs—the mild analgetics. N Engl J Med 286:20-23, 1972 CrossrefMedlineGoogle Scholar4. STOLLEYBECKERLASAGNA PML: The relationship between physician characteristics and prescribing appropriateness. Med Care 10:17-28, 1972 CrossrefMedlineGoogle Scholar5. BECKERSTOLLEYLASAGNA MPL: Characteristics and attitudes of physicians associated with the prescribing of chloramphenicol. HSMHA Health Rep 86:993-1003, 1971 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMethodologies and Approaches in Drug Utilisation StudiesAvailability and cost of urinary antibacterials in a metropolitan area 1 April 1972Volume 76, Issue 4Page: 663-664KeywordsAntibioticsDrugs ePublished: 1 December 2008 Issue Published: 1 April 1972 PDF downloadLoading ...
Risk of HCC recurrence with cellular immunotherapy following radiofrequency ablation.
Authors: Jiuwei Cui, Wei Li, Nanya Wang, Hengjun Zhao, Haofan Jin, Chao Niu, Guanjun Wang
Journal: Journal of Clinical Oncology (2013)

3031 Background: Although radiofrequency ablation (RFA) has brought promising therapeutic outcome in hepatocellular carcinoma (HCC) treatment, the curative rate was compromised by high recurrence and metastasis after RFA. Immunosupression in patients with HCC is an important factor leading to its recurrence and metastasis. This study was designed to observe the efficiency and safety of application of cellular immunotherapy (CIT) after RFA for HCC patients. Methods: Sixty-two patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer cells, γδT cells, cytokine-induced killer cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for 3 or 6 courses. The tumor recurrent status of these patients was evaluated with computed tomography (CT) every 3 months after RFA. Progression-free survival (PFS), liver function, viral load, and adverse effects were examined. Results: The median PFS in RFA group was 12.0 (9.1-14.8) months while median PFS in RFA/CIT group has not yet been reached. It indicated that sequential RFA/CIT significantly reduced the risk of HCC recurrence [hazard ratio (HR) = 0.136]. In RFA/CIT group, six courses had better survival prognosis than three courses (P &lt;0.05). Viral load of hepatitis C decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA alone group. The RFA/CIT group maintained the hepatic function at the level before CIT. The hepatic function in 28.1% (9/32 cases) patients in RFA group was deteriorated. Only one developed fever (38.5 °C) after one infusion and recovered 2 hours later. Otherwise, there was no toxic effect in the RFA/CIT group. Conclusions: These preliminary results suggested that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA. It also suggested that the CIT may reduce the risk of recurrence by dual effects of anti-tumor and anti-virus.
Molecular Characterization of a Novel Chromosomal Translocation t(12;14)(q23;q11.2) in T-Lymphoblastic Lymphoma Between the T Cell Receptor Delta Deleting Elements (TRDREC and TRAJ61) and the Hypothetical Gene C12orf42.
Authors: Grzegorz K Przybylski, Kathleen Dittmann, Piotr Grabarczyk, Gottfried Dölken, Christoph Busemann, Stefan Gesk, Lana Harder, Eva Landmann, Reiner Siebert, Christian A. Schmidt
Journal: Blood (2009)
Phase I/II study of cisplatin (CDDP) and docetaxel (DOC) with concurrent chest radiotherapy followed by full dose of consolidation chemotherapy with CDDP/DOC in locally advanced non-small cell lung cancer
Authors: M. Ichiki, R. Fujiki, M. Hanada, T. Kitajima, H. Aizawa
Journal: Journal of Clinical Oncology (2005)

7108 Objective: Concurrent chemoradiotherapy using docetaxel has been shown to improve the survival of patients with locally advanced non-small cell lung cancer (NSCLC). We conducted a phase I/II study to identify the maximum tolerated dose (MTD) and dose limiting toxicity (DLT) of this regimen and to evaluate the efficacy and safety when administered with concomitant chest radiation (RT) in patients with locally advanced NSCLC. Methods: In a phase I study, standard chest radiotherapy (30 daily 2-Gy fractions for a total of 60 Gy) and concurrent chemotherapy with cisplatin (CDDP) starting at 60 mg/m2 on day 1 every 4 weeks and docetaxel (DOC) starting at 20 mg/m2 on days 1 and 8 (total 2 courses), were followed by consolidation chemotherapy with full-dose CDDP(80 mg/m2 on day 1, 29)/DOC(60 mg/m2 on days 1, 29). Results: The recommended dose for phase II was CDDP 70mg/m2 on day 1 and DOC 25 mg/m2 on days 1 and 8 every 4 weeks with concomitant chest RT. DLTs were esophagitis and febrile neutropenia. In the phase II study, previously untreated advanced stage III NSCLC pts (10F, 33M). Patients: median age, 66 (range 46–74); PS 0/1(56%/44%); stage IIIa,12pts (28%). Grade3,/4 toxicity: neutropenia, 28pts; anemia, 10pts; thrombocytopenia, 4pts; esophagitis 4pts; pneumonitis 2pts. Tumor response was confirmed in 33 of the 43 pts (response rate, 76.7%; 95% confidence interval, 64% to 89%). The median survival time was 22 months and two-year survival rate was 44%. Conclusion: This concurrent chemoradiotherapy with near-full dose CDDP/DOC followed by full dose CDDP/DOC consolidation chemotherapy is a well-tolerated regimen with promising survival results. The update date will be presented at the meeting. No significant financial relationships to disclose.
Design Advances in Particulate Systems for Biomedical Applications
Authors: Ana Catarina Lima, Carmen Alvarez‐Lorenzo, João F. Mano
Journal: Advanced Healthcare Materials (2016)

The search for more efficient therapeutic strategies and diagnosis tools is a continuous challenge. Advances in understanding the biological mechanisms behind diseases and tissues regeneration have widened the field of applications of particulate systems. Particles are no more just protective systems for the encapsulated drugs, but they play an active role in the success of the therapy. Moreover, particles have been explored for innovative purposes as templates for cells growth and as diagnostic tools. Until few years ago the most relevant parameters in particles formulation were the chemistry and the size. Currently, it is known that other physical characteristics can remarkably affect the performance of particulate systems. Particles with non‐conventional shapes exhibit advantages due to the increasing circulation time in blood stream, less clearance by the immune system and more efficient cell internalization and trafficking. Creation of compartments has been found useful to control drug release, to tune the transport of substances across biological barriers, to supply the target with more than one bioactive agent or even to act as theranostic systems. It is expected that such complex shaped and compartmentalized systems improve the therapeutic outcomes and also the patient's compliance, acting as advanced devices that serve for simultaneous diagnosis and treatment of the disease, combining agents of very different features, at the same time. In this review, we overview and analyse the most recent advances in particle shape and compartmentalization and applications of newly designed particulate systems in the biomedical field.
C4-01: Thoracoscopic en-bloc pleural biopsy using an insulation-tipped diathermic knife for unexplained pleural effusion
Authors: Shinji Sasada, Kunimitsu Kawahara, Masashi Kobayashi, Teruo Iwasaki, Tomoki Michida, Tomonori Hirashima, Hidekazu Suzuki, Norio Okamoto, Kaoru Matsui, Teruomi Miyazawa
Journal: Journal of Thoracic Oncology (2007)
Platelet monoamine oxidase activity in schizophrenia
Authors: H L White, M N McLeod, J R Davidson
Journal: American Journal of Psychiatry (1976)

The activity of platelet monoamine oxidase in 12 chronic schizophrenic patients was not significantly different from that in a matched group of normal individuals. The authors emphasize the importance of simultaneous processing of control and patient blood samples and the use of carefully controlled techniques, since relatively minor changes in procedure can markedly influence platelet yield and leucocyte contamination.
Prognostic Pre-Transplant Factors in Myelodysplastic Syndromes Primarily Treated by Allogeneic Hematopoietic Stem Cell Transplantation: A Retrospective Study on Behalf of the MDS Subcommittee of the Chronic Leukaemia Working Party of the EBMT
Authors: Eline Cremers, Anja van Biezen, Liesbeth C. de Wreede, Marijke Scholten, Antonin Vitek, Jürgen Finke, Uwe Platzbecker, Dietrich Beelen, Rainer Schwerdtfeger, Liisa Volin, Nikolaos Harhalakis, Anton Schattenberg, Arnon Nagler, Theo de Witte, Nicolaus Kröger
Journal: Blood (2011)
Long-Term Exposure to Air Pollution and Increased Risk of Membranous Nephropathy in China
Authors: Xin Xu, Guobao Wang, Nan Chen, Tao Lu, Sheng Nie, Gang Xu, Ping Zhang, Yang Luo, Yongping Wang, Xiaobin Wang, Joel Schwartz, Jian Geng, Fan Fan Hou
Journal: Journal of the American Society of Nephrology (2016)

The effect of air pollution on the changing pattern of glomerulopathy has not been studied. We estimated the profile of and temporal change in glomerular diseases in an 11-year renal biopsy series including 71,151 native biopsies at 938 hospitals spanning 282 cities in China from 2004 to 2014, and examined the association of long-term exposure to fine particulate matter of <2.5 μm (PM2.5) with glomerulopathy. After age and region standardization, we identified IgA nephropathy as the leading type of glomerulopathy, with a frequency of 28.1%, followed by membranous nephropathy (MN), with a frequency of 23.4%. Notably, the adjusted odds for MN increased 13% annually over the 11-year study period, whereas the proportions of other major glomerulopathies remained stable. During the study period, 3-year average PM2.5 exposure varied among the 282 cities, ranging from 6 to 114 μg/m3 (mean, 52.6 μg/m3). Each 10 μg/m3 increase in PM2.5 concentration associated with 14% higher odds for MN (odds ratio, 1.14; 95% confidence interval, 1.10 to 1.18) in regions with PM2.5 concentration >70 μg/m3 We also found that higher 3-year average air quality index was associated with increased risk of MN. In conclusion, in this large renal biopsy series, the frequency of MN increased over the study period, and long-term exposure to high levels of PM2.5 was associated with an increased risk of MN.
P4 Patient and Carer Co-investigators: Shared experiences of a Research Steering Group from the Idiopathic Pulmonary Fibrosis Patient Reported Outcome Measure (IPF-PRoM) study: Abstract P4 Table 1
Authors: AM Russell, AM Doyle, D Ross, C Burdett, J Gane, S Fleming, Z Aden, TM Maher, P Cullinan
Journal: Thorax (2015)

<h3>Introduction</h3> The IPF-PROM development project sought to integrate patients and carers both as participants and co-investigators in the research process. Patients with varied experiences of IPF and members of the multidisciplinary team including a clinical psychologist; research nurses, Patient and Public Involvement Lead and a carer formed the IPF-PROM Research Steering Group (RSG) at the outset of the study. <h3>Methodology</h3> Fundamental to PROM development is a robust approach to the item generation process to support the final conceptual framework. The RSG had a key role to ensure patient language was accurately represented. All RSG members: Agreed formal terms of reference and role descriptions. Reviewed the study protocol. Analysed 5 focus groups transcripts individually and collectively identified themes. Applied consensus methods to a list of pooled items collated from questionnaires that have been used in studies in IPF populations. Assessed the face validity of an electronic Delphi survey administered to patients, carers and healthcare professionals in the UK. Analysed the free-text comments captured in the Delphi study using a thematic approach. Participated in a Reflective exercise to characterise individual’s perceptions and motivations for continuing involvement in the RSG. <h3>Results</h3> RSG members contributed a level of sympathy, insight, compassion and knowledge to the thematic analysis of the focus groups: a dynamic that enhanced the interpretation of transcripts. Emotions evoked by the transcripts were ‘therapeutic’ rather than ‘distressing’. 200 statements were identified for inclusion in the Delphi. Patient and carers added new and different perspectives on the use of language; rich discussion preceded consensus. Items identified in existing questionnaires (n = 315) were reduced (n = 58). An additional 18 items were discussed and modified prior to inclusion in the Delphi. Several themes were identified following the reflective exercise encapsulating the group experience. Motivation to work in the RSG whether professionally or personally driven felt complementary, resulting in a sense of connexion; personal/professional belonging and learning together (Table 1). <h3>Discussion</h3> We advocate the RSG model as feasible, sustainable and enriching component of the research experience, specifically in PRO development to enhance content validity. Participating in group reflection has enhanced our understanding of the RSG dynamic.
Epidemiology and Characteristics of Pain in Blood-Related Disorders: A Longitudinal Study on Italian Adult Hospitalized Patients.
Authors: Pasquale Niscola, Luca Cupelli, Claudio Romani, Claudio Cartoni, Daniela Piccioni, Teresa Dentamaro, Benedetta Neri, Andrea Tendas, Marco Giovannini, Luca Maurillo, Sergio Amadori, Paolo De Fabritiis
Journal: Blood (2006)
Let's programme exercise during haemodialysis (intradialytic exercise) into the care plan for patients, regardless of age
Authors: Thibault Deschamps
Journal: British Journal of Sports Medicine (2016)

Exercise programmes have been called for in routine care plans for patients with chronic kidney disease,1 ,2 but nephrologists still hesitate to prescribe exercise during haemodialysis,3 especially for patients with end-stage renal disease (ESRD). One reason may be the age of patients with ESRD, a vulnerable population at high risk of mortality. Now more than ever, whether for paediatric patients4 or older patients (>65 years of age),5 let's challenge this intrinsic reluctance by advocating intradialytic exercise programmes as part of the standard care for patients receiving dialysis.

Exercise is effective for patients with ESRD6—it increases maximal oxygen uptake capacity, improves blood-pressure control, decreases arterial stiffness, decreases systemic inflammation, improves solute removal by dialysis, increases muscle force, and augments perceived quality of life (QoL). Beyond outstanding issues regarding the precise exercise prescription (endurance vs resistance training), the critical question is not whether to include …
Routine on-line psychiatric diagnosis by computer
Authors: J H Greist, M H Klein, H P Erdman
Journal: American Journal of Psychiatry (1976)

With the advent of effective psychiatric treatments, greater accuracy in psychiatric diagnosis has become a vital concern for psychiatric training, research, and patient care. The authors have adapted current computer diagnostic procedures in order to obtain highly accurate diagnosis while simplifying and shortening the process of information input and diagnostic output. Their program requires a minimum of the clinician's time and provides feedback during the diagnostic process when the clinician requires it. The authors believe that routine use of this computer diagnostic program will improve psychiatric training, research, and patient care.
THE OCCURRENCE OF PELLAGRA IN PATIENTS APPARENTLY RECEIVING AN AMPLE DIET
Journal: JAMA (1921)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Impact of Post-Remission Treatments in Patients Aged 65–70 Years with De Novo AML: A Comparison of Two Concomitant Randomized ALFA Trials with Overlapping Age Inclusion Criteria
Authors: Raphael Itzykson, Claude Gardin, Cécile Pautas, Xavier Thomas, Pascal Turlure, Emmanuel Raffoux, Christine Terré, Sylvie Castaigne, Hervé Dombret, Nicolas Boissel
Journal: Blood (2008)
A Complex Cause of Pleuritic Chest Pain
Authors: Lindsay Y. King, J. Kevin Tucker, Linda S. Lee, Bruce D. Levy, Joseph Loscalzo
Journal: New England Journal of Medicine (2012)

A 33-year-old man presented to the emergency department with pain in the right side of his chest. The pain had started 5 days earlier and was worse with deep inspiration and recumbency. He also noted mild swelling of his lower legs over the preceding several weeks.
Case 37-1963
Authors: Irving P. Ackerman, Benjamin Castleman
Journal: New England Journal of Medicine (1963)

Presentation of Case First admission. A sixty-nine-year-old widow was admitted to the hospital because of palpitation and weakness.The patient had been in good health until five years before entry, when she began to experience episodes of rapid heart action. Three months before admission marked weakness and dyspnea developed, and she was able to walk only a few steps without pausing for rest. Digoxin therapy was begun, but her salt intake was not restricted. She was moderately anorectic and lost 20 pounds in weight during the interval before entry. Almost continuous palpitation occurred for several weeks before admission; there . . .