tbuckley/cabot-search huggingface dataset:
What Should Be the Screening Strategy for Familial Hypercholesterolemia?
Authors: Brian W. McCrindle, Samuel S. Gidding
Journal: New England Journal of Medicine (2016)

Familial hypercholesterolemia, a common genetic disorder that affects approximately 1 in 250 persons, is associated with elevated low-density lipoprotein (LDL) cholesterol levels throughout life.1 When heterozygous familial hypercholesterolemia is not treated, premature atherosclerotic cardiovascular disease occurs in approximately 25% of affected women and in approximately 50% of affected men. Long-term treatment with statins has been associated with a greatly improved prognosis. Nonetheless, the condition is underdiagnosed, particularly among children and adolescents.In the study by Wald et al., reported in this issue of the Journal,2 a total of 10,095 children 1 to 2 years of age who attended routine immunization . . .
ANÁLISIS COMPARATIVO DE RENTABILIDAD DIAGNÓSTICA ENTRE ECOENDOSCOPIA Y TOMOGRAFÍA COMPUTARIZADA EN EL ESTADIAJE PREOPERATORIO DEL CÁNCER GÁSTRICO
Authors: M Cimavilla Román, LA Loza Vargas, C De La Serna Higuera, L Sancho Del Val, J Barrio Andrés, C Benito Fernandez, B Madrigal Rubiales, G Fernández Pérez, I Peñas Herrero, M Pérez-Miranda Castillo
Journal: Endoscopy (2016)

Introducción: El adenocarcinoma gástrico (ADG) es uno de los tumores gastrointestinales más frecuentes. El estadiaje prequirúrgico locorregional es esencial para individualizar el tratamiento, pues se recomienda valorar neoadyuvancia en estadios localmente avanzados (T3-T4 y N+). La ecoendoscopia (USE) y la Tomografía computarizada (TC) son dos técnicas utilizadas en el estudio de extensión locorregional, sin embargo hay pocos trabajos que comparen su rentabilidad diagnóstica.
Induction Therapy With Continuous Alternate-Day Low Dose Lenalidomide Combined With Low-Dose Prednisone In Octogenarian Multiple Myeloma Patients
Authors: Luca Pezzullo, Bianca Serio, Raffaele Fontana, Idalucia Ferrara, Mariarosaria Sessa, Valentina Giudice, Giancarlo Villani, Monia Rocco, Carmine Selleri
Journal: Blood (2013)
Application of carbon nanoparticles accelerates the rapid recovery of parathyroid function during thyroid carcinoma surgery with central lymph node dissection: A retrospective cohort study
Authors: Bin Wang, Zhi-Peng Du, Nian-Cun Qiu, Miao-E Liu, Sheng Liu, Dao-Zhen Jiang, Wei Zhang, Ming Qiu
Journal: International Journal of Surgery (2016)
Retrospective Survey of Japanese Patients with Transfusion-Dependent Myelodysplastic Syndromes and Aplastic Anemia Highlights the Negative Impact of Iron Overload on Morbidity/Mortality.
Authors: M. Takatoku, T. Uchiyama, S. Okamoto, Y. Kanakura, K. Sawada, M. Tomonaga, S. Nakao, T. Nakahata, M. Harada, T. Murate, K. Ozawa
Journal: Blood (2006)
Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs
Authors: Cristina Gil-Cruz, Christian Perez-Shibayama, Lucas Onder, Qian Chai, Jovana Cupovic, Hung-Wei Cheng, Mario Novkovic, Philipp A Lang, Markus B Geuking, Kathy D McCoy, Shinya Abe, Guangwei Cui, Koichi Ikuta, Elke Scandella, Burkhard Ludewig
Journal: Nature Immunology (2016)
A phase III, randomized, open-label trial of nivolumab (anti-PD-1; BMS-936558, ONO-4538) versus investigator's choice chemotherapy (ICC) as first-line therapy for stage IV or recurrent PD-L1+ non-small cell lung cancer (NSCLC).
Authors: David Paul Carbone, Mark A. Socinski, Allen C. Chen, Prabhu Bhagavatheeswaran, Martin Reck, Luis Paz-Ares
Journal: Journal of Clinical Oncology (2014)

TPS8128 Background: The majority of NSCLC patients (pts) present at the time of diagnosis with advanced disease. Subsets of pts are eligible for therapies targeted at mutated oncogene drivers; however, the majority of pts have few effective options beyond standard platinum-based chemotherapy. Preclinical data suggest that immune dysfunction, including T-cell downregulation through increased tumor expression of programmed death-1 ligand (PD-L1), plays a role in NSCLC. Nivolumab, a fully human IgG4 PD-1 immune checkpoint inhibitor antibody, has shown clinical activity against several solid tumors including NSCLC. Preliminary data suggest that nivolumab's activity in first-line NSCLC is accentuated in pts with positive tumor PD-L1 expression (PD-L1+). This phase III, randomized, open-label trial will compare the clinical activity of first-line nivolumab monotherapy vs ICC in treatment-naïve pts with stage IV or recurrent NSCLC with PD-L1+ tumor expression. Methods: Chemotherapy-naïve pts with ECOG performance status ≤1 and without known EGFR mutations or ALK translocations will be randomized 1:1 to nivolumab (3 mg/kg IV Q2W) or ICC, and stratified by tumor PD-L1 expression level (Dako immunohistochemistry assay) and NSCLC histology. Pts randomized to ICC (maximum of six 3-week cycles) will receive gemcitabine 1250 mg/m2 + cisplatin 75 mg/m2, gemcitabine 1000 mg/m2 + carboplatin AUC 5, or paclitaxel 200 mg/m2 + carboplatin AUC 6 (squamous [sq]), or pemetrexed 500 mg/m2 + either cisplatin 75 mg/m2 or carboplatin AUC 6 (non-sq); with optional crossover to nivolumab. The primary objective is to assess progression-free survival (PFS) with nivolumab vs ICC in pts with strong PD-L1 expression. Secondary objectives are objective response rate and overall survival in strongly PD-L1+ pts, PFS in pts with any PD-L1 expression level, and disease-related symptom improvement. Exploratory objectives include safety, correlation of PD-L1 expression with PFS, pharmacokinetics, pharmacodynamics, pt-reported outcomes, and potential biomarkers. Clinical trial information: NCT02041533.
MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection
Authors: Anda I. Meierovics, Siobhán C. Cowley
Journal: The Journal of Experimental Medicine (2016)

Mucosa-associated invariant T (MAIT) cells are a unique innate T cell subset that is necessary for rapid recruitment of activated CD4+ T cells to the lungs after pulmonary F. tularensis LVS infection. Here, we investigated the mechanisms behind this effect. We provide evidence to show that MAIT cells promote early differentiation of CCR2-dependent monocytes into monocyte-derived DCs (Mo-DCs) in the lungs after F. tularensis LVS pulmonary infection. Adoptive transfer of Mo-DCs to MAIT cell–deficient mice (MR1−/− mice) rescued their defect in the recruitment of activated CD4+ T cells to the lungs. We further demonstrate that MAIT cell–dependent GM-CSF production stimulated monocyte differentiation in vitro, and that in vivo production of GM-CSF was delayed in the lungs of MR1−/− mice. Finally, GM-CSF–deficient mice exhibited a defect in monocyte differentiation into Mo-DCs that was phenotypically similar to MR1−/− mice. Overall, our data demonstrate that MAIT cells promote early pulmonary GM-CSF production, which drives the differentiation of inflammatory monocytes into Mo-DCs. Further, this delayed differentiation of Mo-DCs in MR1−/− mice was responsible for the delayed recruitment of activated CD4+ T cells to the lungs. These findings establish a novel mechanism by which MAIT cells function to promote both innate and adaptive immune responses.
Renal Fanconi Syndrome and Hypophosphatemic Rickets in the Absence of Xenotropic and Polytropic Retroviral Receptor in the Nephron
Authors: Camille Ansermet, Matthias B. Moor, Gabriel Centeno, Muriel Auberson, Dorothy Zhang Hu, Roland Baron, Svetlana Nikolaeva, Barbara Haenzi, Natalya Katanaeva, Ivan Gautschi, Vladimir Katanaev, Samuel Rotman, Robert Koesters, Laurent Schild, Sylvain Pradervand, Olivier Bonny, Dmitri Firsov
Journal: Journal of the American Society of Nephrology (2016)

Tight control of extracellular and intracellular inorganic phosphate (Pi) levels is critical to most biochemical and physiologic processes. Urinary Pi is freely filtered at the kidney glomerulus and is reabsorbed in the renal tubule by the action of the apical sodium-dependent phosphate transporters, NaPi-IIa/NaPi-IIc/Pit2. However, the molecular identity of the protein(s) participating in the basolateral Pi efflux remains unknown. Evidence has suggested that xenotropic and polytropic retroviral receptor 1 (XPR1) might be involved in this process. Here, we show that conditional inactivation of Xpr1 in the renal tubule in mice resulted in impaired renal Pi reabsorption. Analysis of Pi transport in primary cultures of proximal tubular cells or in freshly isolated renal tubules revealed that this Xpr1 deficiency significantly affected Pi efflux. Further, mice with conditional inactivation of Xpr1 in the renal tubule exhibited generalized proximal tubular dysfunction indicative of Fanconi syndrome, characterized by glycosuria, aminoaciduria, calciuria, and albuminuria. Dramatic alterations in the renal transcriptome, including a significant reduction in NaPi-IIa/NaPi-IIc expression, accompanied these functional changes. Additionally, Xpr1 -deficient mice developed hypophosphatemic rickets secondary to renal dysfunction. These results identify XPR1 as a major regulator of Pi homeostasis and as a potential therapeutic target in bone and kidney disorders.
TCT-494 Very long-term (8-year) angiographic and clinical outcomes after biodegradable polymer-based biolimus-eluting stent implantation
Authors: Masanobu Ohya, Akimune Kuwayama, katsuya miura, Takenobu Shimada, Hidewo Amano, Shunsuke Kubo, Yusuke Hyodo, Suguru Otsuru, Seiji Habara, Takeshi Tada, Hiroyuki Tanaka, Yasushi Fuku, Tsuyoshi Goto, Kazushige Kadota
Journal: Journal of the American College of Cardiology (2016)
An evidence-based treatment algorithm for colorectal polyp cancers: results from the Scottish Screen-detected Polyp Cancer Study (SSPoCS)
Authors: CH Richards, NT Ventham, D Mansouri, M Wilson, G Ramsay, CD Mackay, CN Parnaby, D Smith, J On, D Speake, G McFarlane, YN Neo, E Aitken, C Forrest, K Knight, A McKay, H Nair, C Mulholland, JH Robertson, FA Carey, RJC Steele
Journal: Gut (2016)

Objectives Colorectal polyp cancers present clinicians with a treatment dilemma. Decisions regarding whether to offer segmental resection or endoscopic surveillance are often taken without reference to good quality evidence. The aim of this study was to develop a treatment algorithm for patients with screen-detected polyp cancers. Design This national cohort study included all patients with a polyp cancer identified through the Scottish Bowel Screening Programme between 2000 and 2012. Multivariate regression analysis was used to assess the impact of clinical, endoscopic and pathological variables on the rate of adverse events (residual tumour in patients undergoing segmental resection or cancer-related death or disease recurrence in any patient). These data were used to develop a clinically relevant treatment algorithm. Results 485 patients with polyp cancers were included. 186/485 (38%) underwent segmental resection and residual tumour was identified in 41/186 (22%). The only factor associated with an increased risk of residual tumour in the bowel wall was incomplete excision of the original polyp (OR 5.61, p=0.001), while only lymphovascular invasion was associated with an increased risk of lymph node metastases (OR 5.95, p=0.002). When patients undergoing segmental resection or endoscopic surveillance were considered together, the risk of adverse events was significantly higher in patients with incomplete excision (OR 10.23, p&lt;0.001) or lymphovascular invasion (OR 2.65, p=0.023). Conclusion A policy of surveillance is adequate for the majority of patients with screen-detected colorectal polyp cancers. Consideration of segmental resection should be reserved for those with incomplete excision or evidence of lymphovascular invasion.
TCT-768 Histopathological Features of Transcatheter Renal Denervation by Radiofrequency Ablation Compared to the Effects Following Chemical Ablation by Perivascular Delivery of a Novel Neurotropic Agent: A Preclinical Perspective
Authors: Armando Tellez, Krista N. Dillon, Emily A. Stein, K.T. Rao, Dane A. Brady, Serge Rousselle
Journal: Journal of the American College of Cardiology (2016)
Multicenter Phase II Trial of Bendamustine, Lenalidomide and Dexamethasone (BRd) As 2nd-Line Therapy for Multiple Myeloma
Authors: Ulrich JM Mey, Wolfram Brugger, Mario Bargetzi, Heike Schwarb, Andreas Schwarzer, Tobias Dechow, Paul Jehner, Jacqueline Rauh, Christian J. Taverna, Mathias Schmid, Martin Schmidt-Hieber, Steffen Doerfel, Natalie Fischer, Axel Ruefer, Carsten Ziske, Wolfgang Knauf, Arnd Nusch, Richard Cathomas, Roger von Moos, Elke Hiendlmeyer, Felicitas Hitz, Christoph Driessen
Journal: Blood (2014)
Potential Pathogenetic Role of Achromobacter (Alcaligenes) Xylosoxidans in Primary Extranodal Marginal Zone Lymphoma of the Lung (BALT-Lymphoma): Update of the Results of a Retrospective Analysis on Behalf of IELSG
Authors: Simona Sammassimo, Giancarlo Pruneri, Patrick Adam, Stefano Pileri, Paola Rafaniello, Sara Steffanoni, Sara Gandini, Mara Negri, Thomas M. Habermann, Zhi-Ming Li, Pier Luigi Zinzani, Markus Raderer, James O. Armitage, Dennis D Weisenburger, Osnat Bairey, Maria Cabrera, Emanuele Zucca, Benedetta Puccini, Gonzalo Gutierrez-Garcia, Ewa Kalinka-Warzocha, Andrea Carpaneto, Caroline Besson, Elena Porro, Franco Cavalli, Grzegorz S. Nowakowski, Giovanni Martinelli
Journal: Blood (2011)
TCT-802 Utilization of Angioplasty and Stenting in Infrainguinal Peripheral Arterial Disease outcomes – 180 days follow-up
Authors: Shilpkumar Arora, Sopan Lahewala, Prashant Patel, Nilay Patel, Byomesh Tripathi, Sidakpal Panaich, Abhishek Deshmukh, Apurva Badheka
Journal: Journal of the American College of Cardiology (2016)
In Vivo Suicide Gene Therapy of Human T Lymphocytes To Prevent Graft Versus Host Disease in a Murine Xenograft Model.
Authors: Bruno Nervi, Michael Rettig, Julie Ritchey, Jon Walker, Gerhard Bauer, Philip Herrbrich, Mark L. Bonyhadi, Jan A. Nolta, John F. DiPersio
Journal: Blood (2004)
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
Authors: Kathryn F. Mills, Shohei Yoshida, Liana R. Stein, Alessia Grozio, Shunsuke Kubota, Yo Sasaki, Philip Redpath, Marie E. Migaud, Rajendra S. Apte, Koji Uchida, Jun Yoshino, Shin-ichiro Imai
Journal: Cell Metabolism (2016)

Highlights•NMN suppresses age-associated body weight gain and enhances energy metabolism•NMN improves insulin sensitivity, eye function, and other features with no toxicity•NMN prevents age-associated gene expression changes in a tissue-specific manner•NMN is an effective anti-aging intervention that could be translated to humansSummaryNAD+ availability decreases with age and in certain disease conditions. Nicotinamide mononucleotide (NMN), a key NAD+ intermediate, has been shown to enhance NAD+ biosynthesis and ameliorate various pathologies in mouse disease models. In this study, we conducted a 12-month-long NMN administration to regular chow-fed wild-type C57BL/6N mice during their normal aging. Orally administered NMN was quickly utilized to synthesize NAD+ in tissues. Remarkably, NMN effectively mitigates age-associated physiological decline in mice. Without any obvious toxicity or deleterious effects, NMN suppressed age-associated body weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and plasma lipid profile, and ameliorated eye function and other pathophysiologies. Consistent with these phenotypes, NMN prevented age-associated gene expression changes in key metabolic organs and enhanced mitochondrial oxidative metabolism and mitonuclear protein imbalance in skeletal muscle. These effects of NMN highlight the preventive and therapeutic potential of NAD+ intermediates as effective anti-aging interventions in humans.Graphical abstract
Simultaneous <i>In Vivo</i> Fluorescent Markers for Perfusion, Protoporphyrin Metabolism, and EGFR Expression for Optically Guided Identification of Orthotopic Glioma
Authors: Jonathan T. Elliott, Kayla Marra, Linton T. Evans, Scott C. Davis, Kimberley S. Samkoe, Joachim Feldwisch, Keith D. Paulsen, David W. Roberts, Brian W. Pogue
Journal: Clinical Cancer Research (2016)

Purpose: While extent of tumor resection is an important predictor of outcome in glioma, margin delineation remains challenging due to lack of inherent contrast between tumor and normal parenchyma. Fluorescence-guided surgery is promising for its ability to enhance contrast through exogenous fluorophores; however, the specificity and sensitivity of the underlying contrast mechanism and tumor delivery and uptake vary widely across approved and emerging agents.Experimental Design: Rats with orthotopic F98 wild-type and F98 EGFR-positive (EGFR+) gliomas received in vivo administration of IRDye680RD, 5-aminioleuvulinic acid, and ABY-029-markers of perfusion, protoporphyrin metabolism, and EGFR expression, respectively. Ex vivo imaging demonstrates the contrast mechanism-dependent spatial heterogeneity and enables within-animal comparisons of tumor-to-background ratio (TBR).Results: Generally, ABY-029 outperformed PpIX in F98EGFR orthotopic tumor margins and core (50% and 60% higher TBR, respectively). PpIX outperformed ABY-029 in F98wt margins by 60% but provided equivalent contrast in the bulk tumor. IRDye680RD provided little contrast, having an average TBR of 1.7 ± 0.2. The unique spatial patterns of each agent were combined into a single metric, the multimechanistic fluorescence-contrast index (MFCI). ABY-029 performed best in EGFR+ tumors (91% accuracy), while PpIX performed best in wild-type tumors (87% accuracy). Across all groups, ABY-029 and PpIX performed similarly (80% and 84%, respectively) but MFCI was 91% accurate, supporting multiagent imaging when tumor genotype was unknown.Conclusions: Human use of ABY-029 for glioma resection should enhance excision of EGFR+ tumors and could be incorporated into current PpIX strategies to further enhance treatment in the general glioma case. Clin Cancer Res; 23(9); 2203-12. ©2016 AACR.
TCT-426 Three and half year experience of bioresorbable vascular scaffold implantation in routine clinical practice in a single centre in India
Authors: Raghuram Palaparti, Gopala Krishna Koduru, Boochi Babu Mannuva, Somasekhar Ghanta, Srinivas Chowdary Parvathaneni, Purnachandra Rao Kondru
Journal: Journal of the American College of Cardiology (2016)
Icariin protects against titanium particle-induced osteolysis and inflammatory response in a mouse calvarial model
Authors: Hongguo Shao, Ji Shen, Mingjun Wang, Jingfu Cui, Yijun Wang, Shijun Zhu, Wen Zhang, Huilin Yang, Yaozeng Xu, Dechun Geng
Journal: Biomaterials (2015)
Synergistic Activity of Adenosine A2A and Beta-2 Adrenergic Receptor Agonists in Myeloma Cells in the Context of Tumor-Stromal Interactions
Authors: Douglas W. McMillin, Richard Rickles, Joseph Negri, Jake Delmore, Melissa G. Ooi, Melissa Farwell, David Crowe, Mei Chen, William Avery, Vikram Kansra, Kenneth C. Anderson, Margaret S. Lee, Constantine S. Mitsiades
Journal: Blood (2008)
The Overexpression of ANKHD1 in Acute Leukemia Cells and Its Association with SIVA-1, a Proapoptotic Protein.
Authors: Fabiola Traina, Patricia M.B. Favaro, Adriana S.S. Duarte, Sheila M.B. Winnschofe, Fernando F. Costa, Sara T.O. Saad
Journal: Blood (2006)
TCT-722 Clinical Effect of New Cerebral Ischemic Lesions on the Occurrence of Postoperative Delirium after Transcatheter Aortic Valve Implantation
Authors: Masieh Abawi, Freek Nijhoff, Pierfrancesco Agostoni, Rehana de Vries, Arjen Slooter, Marielle Emmelot-Vonk, Michiel Voskuil, Jeroen Hendrikse, Tim Leiner, Pieter Doevendans, Pieter Stella
Journal: Journal of the American College of Cardiology (2016)
HEMORRAGIA DIGESTIVA CRONICA SECUNDARIA A SINDROME DE RENDU-OSLER-WEBER
Authors: J Mostazo Torres, M Vilchez Jaimez, IL Pinazo Martinez, JM Ramirez Bollero
Journal: Endoscopy (2016)

La telangiectasia hemorrágica hereditaria es un trastorno familiar de herencia AD infrecuente. Se caracteriza por angiodisplasias viscerales o mucocutáneas, que se distribuyen a través del sistema cardiovascular, la piel, los pulmones, el tubo digestivo y el cerebro. Suele debutar con sangrado recurrente (epistaxis, melenas...). El tratamiento consiste en fulgurar con plasma de argón sobre las malformaciones arteriovenosas, sobre todo cuando las lesiones se sitúan dentro del alcance del endoscopio y no son excesivamente difusas.
Clinical Significance of Genetic Aberrations in Diffuse Large B Cell Lymphoma
Authors: Daisuke Ennishi, Christoffer Hoffer, Hennady Shulha, Anja Mottok, Pedro Farinha, Fong Chun Chan, Barbara Meissner, Merrill Boyle, Susana Ben-Neriah, Ryan D Morin, Marco A. Marra, Kerry J. Savage, Laurie H. Sehn, Joseph M Connors, Christian Steidl, David W. Scott, Randy D. Gascoyne
Journal: Blood (2014)
Peroral endoscopic myotomy: minimally invasive but truly surgical
Authors: Lee Swanström
Journal: Endoscopy (2016)

In this issue of Endoscopy, Zhou’s group from Fudan University, Shanghai, present an update on their experience with peroral endoscopic myotomy (POEM) for achalasia, which now represents the largest, single-institution experience in the world [1]. Their report concentrates on the perioperative complications of POEM and gives us an unparalleled picture of the status of the procedure.
Mantle cell lymphoma initial therapy with abbreviated R-CHOP followed by 90Y-ibritumomab tiuxetan: 10-year follow-up of the phase 2 ECOG-ACRIN study E1499
Authors: M R Smith, F Hong, H Li, L I Gordon, R D Gascoyne, E M Paietta, R H Advani, A Forero-Torres, S J Horning, B S Kahl
Journal: Leukemia (2016)
Multivariate Analysis of Patient and Graft Specific Factors among 330 Recipients of Unrelated Cord Blood Transplant (UCBT) To Predict Risk of Death from Opportunistic Infections in the First 6 Months after UCBT.
Authors: Paul Szabolcs, Bercedis L. Peterson, Donna Niedzwiecki, Nelson Chao, Joanne Kurtzberg
Journal: Blood (2006)
A Phase 1b Study of Panobinostat in Combination with Idarubicin and Ara-C in Patients with High-Risk Acute Myeloid Leukemia
Authors: Daniel J. DeAngelo, Alison R. Walker, Richard F. Schlenk, Jorge Sierra, Bruno C. Medeiros, Enrique M. Ocio, Christoph Röllig, Stephen A. Strickland, Felicitas Thol, Sue-zette Valera, Antje Wegener, Tuli De, Song Mu, Florence Binlich, Robert K. Stuart
Journal: Blood (2015)
Gardos Channel Mutation Is Associated with Hereditary Dehydrate Stomatocytosis: a Complex Channelopathy
Authors: Elisa Fermo, Anna Yu. Bogdanova, Polina Petkova-Kirova, Anna Zaninoni, Anna Paola Marcello, Asya Makhro, Pascal Hänggi, Laura Hertz, Jens Danielczok, Nadia Mirra, Alberto Zanella, Wilma Barcellini, Kaestner Lars, Paola Bianchi
Journal: Blood (2015)
Cardiac Dysfunction Due to Cancer Therapy
Authors: Sergey Ryzhov, Sanjeev Francis, Douglas B. Sawyer
Journal: Circulation Research (2016)

C ardiac toxicity of cancer therapies remains an important clinical problem, despite decades of investigation.The prevention, surveillance, and treatment of cardiac toxicity are areas of active research, stimulated by recent attention from the National Institutes of Health. 1 This has brought new energy and novel methods to the table.For patients facing treatment of cancer, no one size fits all, and several teams of investigators have tried to identify genetic variables or biomarkers that might predict the risk for cardiac injury by anthracyclines and allow for a more personalized approach that allows for a cancer patient to receive the maximal benefit of these powerful chemotherapies at minimal risk.These studies have identified many molecular pathways that may be important determinants of cardiotoxicity and have led to recent proposals for use of genetic testing in this setting.
Donor Genotypes For Interleukin-17A Gene Single Nucleotide Polymorphisms (SNPs) Allow Anticipation Of Complications After HLA-Identical Allogeneic Stem Cell Transplantation (allo-SCT)
Authors: Elena Buces, Carolina Martínez-Laperche, Milagros González-Rivera, A Bosch-Vizcaya, Beatriz Martin-Antonio, Vicent Guillem, Jb Nieto, M. González, Rafael De La Camara, Salut Brunet, Antonio Jimenez-Velasco, Ildefonso Espigado, Carlos Vallejo, Antonia Sampol, David Serrano, Mi Kwon, Jorge Gayoso, Pascual Balsalobre, Alvaro Urbano-Izpizua, Carlos Solano, David Gallardo, José Luis Díez Martín, Ismael Buno
Journal: Blood (2013)