tbuckley/cabot-search huggingface dataset:
FRI0279 Follow-Up Investigation of Efficacy/Safety of Etanercept in Patients Who Successfully Became Pregnant after Its Introduction
Authors: T. Tsuchida
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> High activity levels of rheumatoid arthritis (RA) may lead to reduced fertility or further deterioration of the disease after pregnancy. Therefore, it is important for patients with RA to become pregnant while they are in remission. On the other hand, RA relapses in approximately half of patients within 1 month after delivery.<sup>1</sup> Accordingly, drugs should be selected taking into consideration the overall use before and after pregnancy, and after delivery. <h3>Objectives</h3> The objective of the present study is to investigate the efficacy/safety of monotherapy with etanercept (ETN) in patients with RA who wish to conceive in clinical practice. <h3>Methods</h3> ETN monotherapy was started at our clinic in patients with RA who wish to have a baby. ETN treatment was discontinued, once pregnancy was confirmed. If symptoms recurred after delivery, ETN was reintroduced. For these patients, the course of disease activity, the clinical course after pregnancy, and neonatal growth status after birth were retrospectively analyzed. <h3>Results</h3> Ten patients who successfully became pregnant after the introduction of ETN before October 2013 were included in the analysis. Of these, 8 gave birth, 1 was pregnant, and 1 experienced abortion. The mean score of 28-joint disease activity score using C-reactive protein (DAS28-CRP) levels significantly decreased from 2.92 at the start of therapy to 2.02 at the discontinuation of therapy (when pregnancy was confirmed). For patients for whom ETN was reintroduced because of relapse of RA after the discontinuation of ETN, the mean duration of the drug withdrawal was 310.2 days. The DAS28-CRP score significantly decreased from 3.09 at the reintroduction of ETN to 2.44 at 12 weeks after the resumption. No adverse events were reported, and no abnormalities were found in the observation of neonatal growth status after birth, etc. <h3>Conclusions</h3> Aggressive treatment with biological agents should be used in patients with RA who wish to conceive as necessary. ETN monotherapy was able to be used safely by discontinuing the treatment when pregnancy was confirmed. For its low immunogenicity, ETN may be reintroduced after interruption even though RA relapses. <h3>References</h3> Barrett JH, et al. Arthritis Rheum 1999;42:1219-1227 <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.4916
MARIHUANA INTOXICATION
Authors: Walter Bromberg
Journal: American Journal of Psychiatry (1934)

I. Marihuana is the Latin-American name for a cigarette preparation of the hemp plant. The active principle is cannabis sativa: the drug has various synonyms—hasheesh, ganja, reefers, Indian hemp, etc. It has been used for centuries in the Orient and later in Latin America. Mental states produced by the drug constitute a fairly definite clinical entity. II. A study of the relation between violent crime (murder, assault, rape, etc.) with marihuana showed no direct correlation. It is clear from this study, that in this region the drug is a "breeder of crime" only when used by psychopathic types in whom the drug allows the emergence of aggressive, sexual or anti-social tendencies. The addiction to marihuana is not on the same deep physiological or psychologic level that morphine addiction is. III. The clinical pictures observed can be divided into three groups: (1) Acute intoxications. (2) Emotional reactions to the intoxication features. (3) Toxic psychosis due to admixture of drug effects and basic psychosis (manic-depressive, schizophrenic, etc.). IV. Psychologic factors are of great importance in the emotional reaction of an intoxication, bringing various personality forces and conflicts to the surface. V. The psychologic and physiologic effects of cannabis intoxication have been well studied. They are: (1) A change in time perception, reality feeling, somatic, sensory and motor phenomena. (2) Disturbance of consciousness with difficulty in memory retention. (3) Change in subjective evaluation of perception of visual, tactile, proprioceptive, auditory experiences because of disintegration of sensation to a primitive level of perception. The result of this change in body-model (Körperschema) perception may be expressed in feelings of unreality that appear as panic-states in narcissistic or hysterical individuals. (4) A mood reaction consisting of elevation with periods of sudden boisterous laughter. (5) A primary stimulus to the impulsive life with direct expression in the motor field.
Computers Speed Up the Pace Of Oncology
Authors: S. Kumar
Journal: JNCI Journal of the National Cancer Institute (1989)

Journal Article Computers Speed Up the Pace Of Oncology Get access Seema Kumar Seema Kumar Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 81, Issue 23, 6 December 1989, Pages 1773–1776, https://doi.org/10.1093/jnci/81.23.1773 Published: 06 December 1989
SAT0518 Coping Patterns and Associated Factors in an Inception Cohort of Patients with Gout:
Authors: E. Arnada Arreola, I. Pelaez Ballestas, E. Alvarez Hernandez, M. Rull Gabayet, V. Pascual, R. Burgos-Vargas, J. Vazquez Mellado
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Coping patterns relate to demographic, socioeconomic, clinical, and therapy in patients with chronic diseases. In patients with rheumatic diseases, the evasive pattern is associated with the poorest outcome. <h3>Objectives</h3> To describe coping patterns in patients with gout and its association with clinical variables and therapeutic adherence. <h3>Methods</h3> The study includes a large inception cohort of patients with gout (ACR and CGD criteria) attending the Rheumatology departments of two major hospitals started in 2010. Most patients attending these two hospitals are poor and lack of financial support to cover the cost of medical care. Demographic, clinical, biochemical and therapy variables were recorded at baseline and every six months visits. The HAQ, EuROQoL, and Coping and Adherence questionnaires previously developed and validated in our country, were administered to all patients at every visit. Good adherence (GA) was defined by the intake of ≥80% of the doses prescribed. Statistical analysis included the t, Mann Whitney, χ<sup>2</sup>, and Fisher9s tests. <h3>Results</h3> There were 235 patients with gout (97% males, mean age 47.7±12.6 years and mean disease duration 14.2±10.2 years, 66% tophaceous) with an educational level of 9.4±4.2 years at baseline. Coping patterns were evasive in 70% of the patients whereas 14% and 13% showed a negative emotional pattern + others or a revalorative + direct pattern, respectively. The association between evasive pattern and a lower educational level, more severe disease (number of acute flares, bigger tophi size, HAQ, VAS for pain and general health) was highly significant. Evasive pattern was still the most frequently found in 43% patients that completed the 12th month evaluation. Interestingly, 78% of the patients with evasive pattern in both visits have good therapeutic adherence, but have more severe disease (see table). <h3>Conclusions</h3> In patients with gout, evasive was the most frequent pattern of coping with the disease found in this study. Factors associated with this pattern include low educational level and severe disease. Interestingly, it does not seem associated with adherence and clinical response to treatment. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.2970
A Bird's-Eye View of Fever
Authors: Alfred Ian Lee, Sophia Koo, Anand Vaidya, Joel T. Katz, Joseph Loscalzo
Journal: New England Journal of Medicine (2011)

A 78-year-old man presented with a 4-month history of worsening fatigue, weakness, and anorexia, with an unintentional weight loss of 11.4 kg. He reported fevers, chills, night sweats, dry mouth, nonproductive cough, dyspnea with minimal exertion, nausea, and postural light-headedness.
Abstract 2861: The C/EBPbeta isoform, liver-inhibitory protein (LIP), induces autophagy in breast cancer cell lines
Authors: Maria M. Abreu, Linda Sealy
Journal: Cancer Research (2011)

Abstract Autophagy is an evolutionarily conserved cellular process involving the bulk degradation of cellular components in the cytoplasm via the lysosomal degradation pathway. Autophagy manifests a protective role in stressful conditions such as nutrient or growth factor depletion; however, extensive degradation of regulatory molecules or organelles essential for survival can lead to the demise of the cell, or autophagy-mediated cell death. The role of autophagy in cancer is controversial with roles in both tumor suppression and tumor promotion proposed. Here we report that an isoform of the C/EBPbeta transcription factor, liver-enriched inhibitory protein (LIP), stimulates autophagy and induces cell death in human breast cancer cells. LIP overexpression is incompatible with cell growth and when cell cycle analysis was performed, a DNA profile of cells undergoing apoptosis was not observed. Instead, LIP expressing cells appeared to have large autophagic vesicles when examined via electron microscopy. Autophagy was further assessed in LIP expressing cells by monitoring the development of acidic vesicular organelles and conversion of LC3 from the cytoplasmic form to the membrane-bound form. Our work shows that C/EBPbeta isoform, LIP, is another member of the group of transcription factors, including E2F1 and p53, which are capable of playing a role in autophagy. Knowledge of the mechanisms controlling autophagy and identifying new agents capable of inducing cell death has vast potential to improve cancer therapeutics by enabling effective induction of an alternative death pathway, especially in, but not limited to, tumor cells that are resistant to apoptosis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 2861. doi:10.1158/1538-7445.AM2011-2861
Hiatal Hernia Mimics Centrally Necrotic Cancer in the Lung on FDG Positron Emission Tomographic Imaging
Authors: PEEYUSH BHARGAVA, HONGMING ZHUANG, ABASS ALAVI
Journal: Clinical Nuclear Medicine (2003)

BHARGAVA, PEEYUSH M.D.; ZHUANG, HONGMING M.D., PH.D.; ALAVI, ABASS M.D. Author Information
Abstract 1254: Tumor infiltrating M1 macrophages work side by side with T cells to prolong the survival in patients with cervical carcinoma.
Authors: Sjoerd H. Van Der Burg, Peggy de Vos van Steenwijk, Thorbald van Hall, Ekaterina S. Jordanova
Journal: Cancer Research (2013)

Abstract One of the hallmarks of cancer is the influx of myeloid cells. In this study we exploited a cohort of 86 patients with cervical carcinoma to investigate the constitution of cervical cancer infiltrating myeloid cells and their relationship to other tumor infiltrating immune cells, tumor characteristics and the survival of patients. Triple color immunofluorescent confocal microscopy was used to locate, identify and quantify macrophages (CD14), their maturation status (CD33) and their polarization (CD163). Quantification of the numbers of populations of myeloid cells based on the expression of these three markers revealed that a strong intraepithelial infiltration of CD14+ cells, more specifically the population of CD14+CD33-CD163- M1 macrophages, is associated with a large general influx of intraepithelial T lymphocytes (p=0.008) and improved survival (p=0.007) as well as forms an independent prognostic factor for survival (p=0.033). The ratio of intraepithelial CD8+ T-cells / Tregs also formed an independent prognostic factor (p=0.010). Combination of these two factors revealed a dramatic difference in survival between the group of patients whose tumor was well infiltrated with intraepithelial M1 macrophages and relatively high numbers of CD8+ T-cells compared to Tregs (100%) and the group of patients whose tumor displayed a low infiltration with M1 macrophages and a low CD8+ T-cell / Treg ratio (50%), indicating that these two populations of immune cells work side by side to improve survival. Our data suggests that reinforcement and activation of the intratumoral M1 macrophages may form an attractive immunotherapeutic option in cervical cancer. Citation Format: Sjoerd H. Van Der Burg, Peggy de Vos van Steenwijk, Thorbald van Hall, Ekaterina S. Jordanova. Tumor infiltrating M1 macrophages work side by side with T cells to prolong the survival in patients with cervical carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1254. doi:10.1158/1538-7445.AM2013-1254
Early Management of Shock and Prophylaxis of Acute Renal Failure in Traumatic Rhabdomyolysis
Authors: Jane F. Desforges, Ori S. Better, Jay H. Stein
Journal: New England Journal of Medicine (1990)

SEISMIC catastrophes leave in their wake survivors trapped under the rubble who suffer from extensive muscle damage and its devastating sequelae of hemodynamic and metabolic disturbances and acute renal failure.1 We review here the pathogenesis of shock and acute renal failure associated with traumatic rhabdomyolysis and suggest guidelines for the early management of shock and the prophylaxis of acute renal failure due to the crush syndrome.Rhabdomyolysis, myoglobinuria, and renal failure have been known to follow massive crush injury.2 3 4 5 6 Indeed, it is now 50 years after the classic description of the crush syndrome in patients injured during the bombing of . . .
Effects of the Early Administration of Enalapril on Mortality in Patients with Acute Myocardial Infarction
Authors: K Swedberg, P Held, J Kjekshus, K Rasmussen, L Rydén, H Wedel
Journal: New England Journal of Medicine (1992)

Long-term administration of angiotensin-converting—enzyme (ACE) inhibitors has been shown to improve survival in patients with symptomatic left ventricular failure and to attenuate left ventricular dilatation in patients with myocardial infarction. We studied whether mortality could be reduced during the 6 months after an acute myocardial infarction with use of the ACE inhibitor enalapril.
Abstract 2259: Blockade of CXC chemokines/CXCR2 axis inhibits pancreatic ductal adenocarcinoma progression through anti-angiogenesis
Authors: Hideaki Ijichi, Motohisa Tada, Koji Miyabayashi, Mitsuho Imai, Dai Mohri, Yoshinari Asaoka, Tsuneo Ikenoue, Keisuke Tateishi, Masao Omata, Harold L. Moses
Journal: Cancer Research (2010)

Abstract Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal neoplasms, is characterized histologically by expanded stromal components with marked fibrosis, which suggests that tumor-stromal interaction might play an important role in PDAC progression. We have established pancreas epithelium-specific transforming growth factor-ß receptor type II (Tgfbr2) knockout mice in the context of active Kras (KrasG12D) expression (Kras+Tgfbr2KO) (Ijichi et al., Genes Dev. 2006), which developed differentiated PDAC with 100% penetrance and recapitulated histology of human PDAC described above. In the AACR annual meeting 2009, we reported that tumor-stromal interaction in the PDAC model promoted tumor progression and blockade of CXC chemokines/CXCR2 axis inhibited tumor growth and extended survival of the mice. We examined the underlying mechanisms of anti-tumor effects. Treating the Kras+Tgfbr2KO PDAC mice with the CXCR2 inhibitor decreased CTGF expression and macrophage infiltration in vivo, resulting in decrease of microvessel density and inhibiton of tumor size. The CXC chemokines released from the PDAC cells, CTGF, macrophage, are all considered to promote angiogesis. Taken together, treatment of the mice with the CXCR2 inhibitor achieved anti-tumor effects through anti-angiogenesis via modulating network of an array of components in the tumor microenvironment. On the other hand, treating the mice with gemcitabine, a standard chemoreagent for PDAC, also showed anti-tumor effects, but it was not through anti-angiogenesis. PDAC is well known as a hypovascular tumor, however, angiogenesis might be important for tumor progression and could be a potent therapeutic target. Pursuing optimum combination of anti-angiogenesis and a conventional chemotherapy would provide us a more effective therapeutic strategy for PDAC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2259.
Abstract 3207: Application of an antibody-free, highly sensitive PRISM-SRM proteomics approach for monitoring low abundance proteins and protein isoforms in cell lines and tumor tissue.
Authors: Jintang He, Xuefei Sun, Tujin Shi, Athena Schepmoes, Thomas Fillmore, Vladislav Petyuk, Fang Xie, Marina Gritsenko, Feng Yang, Naoki Kitabayashi, Sung Suk Chae, Mark Rubin, Javed Siddiqui, John Wei, Arul Chinnaiyan, Wei-Jun Qian, Richard Smith, Jacob Kagan, Sudhir Srivastava, Tao Liu, Karin Rodland, David Camp
Journal: Cancer Research (2013)

Abstract Stable-isotope dilution coupled to targeted mass spectrometry, applying selected reaction monitoring (SRM), provides good selectivity, reproducibility, and sensitivity rendering it highly suitable for robust and high-throughput protein quantification. Historically, SRM sensitivity for measuring protein concentration in biofluids such as blood plasma has been limited to the low μg/mL level. Application of front-end sample preparation methods such as immunoaffinity depletion and strong cation exchange (SCX) chromatographic fractionation has improved the SRM detection limit to low ng/mL level. The ability to detect and quantify low abundance proteins present in blood plasma/serum at sub-ng/mL levels, however, relies on the availability of specific affinity reagents (e.g., antibodies that have the associated disadvantage of an expensive, lengthy, and high failure rate de novo process). To address this limitation, we have recently developed an antibody-free, targeted quantification capability that enables protein quantification of prostate-specific antigen and other exogenous proteins at 50-100 pg/mL levels in plasma/serum. Unlike the traditional SCX fractionation approach where all resulting fractions are analyzed by the second dimension LC-SRM, this new capability, PRISM (high-pressure high-resolution separations with intelligent selection and multiplexing), uses high resolution. Citation Format: Jintang He, Xuefei Sun, Tujin Shi, Athena Schepmoes, Thomas Fillmore, Vladislav Petyuk, Fang Xie, Marina Gritsenko, Feng Yang, Naoki Kitabayashi, Sung Suk Chae, Mark Rubin, Javed Siddiqui, John Wei, Arul Chinnaiyan, Wei-Jun Qian, Richard Smith, Jacob Kagan, Sudhir Srivastava, Tao Liu, Karin Rodland, David Camp. Application of an antibody-free, highly sensitive PRISM-SRM proteomics approach for monitoring low abundance proteins and protein isoforms in cell lines and tumor tissue. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3207. doi:10.1158/1538-7445.AM2013-3207
Case 20-2000
Authors: William G. Stevenson, H. Thomas Aretz
Journal: New England Journal of Medicine (2000)

Presentation of CaseA 61-year-old man was admitted to the hospital because of a wide-complex tachycardia and dyspnea.The patient had been well until one month earlier, when he was assaulted and sustained an orbital fracture, associated with blurred vision. Soon thereafter, in the hope of improving his vision, he began to take dietary supplements identified as bilberry, Ginkgo biloba, alpha lipoic acid, omega-3 fish oil, lecithin, and S-adenosylmethionine, in addition to vitamins E, C, and B complex. Two days before admission, nausea, vomiting, diarrhea, and midepigastric pain developed several hours after dinner. On the following morning, he awoke . . .
P4-09-26: Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 (TIMP-1) in Breast Cancer.
Authors: A Dechaphunkul, M Phukaoloun, K Kanjanapradit, K Graham, S Ghosh, C Santos, JR Mackey
Journal: Cancer Research (2011)

Abstract Background: Despite advances of systemic treatment in breast cancer guided by hormonal status and HER2 amplification, new prognostic and predictive factors are still warranted to optimize treatments among these patients. Tissue Inhibitor of Metalloproteinase-1 (TIMP-1), a physiologic inhibitor of Matrix Metalloproteinases (MMPs), can act in both pro- and anti-tumoral effects. The prognostic significance of TIMP-1 in breast cancer is still controversial. This study aims to determine the prognostic significance of TIMP-1 in breast cancer. Material and Methods: One-hundred and seventy-six primary breast cancers from women with early stage disease treated with standard adjuvant therapy were analyzed by gene expression microarrays and immunohistochemistry for TIMP-1. Immunohistochemical analysis was independently reviewed by two pathologists. Results: At the optimized cut-off point, patients with high TIMP-1 RNA levels had a significantly shorter time to relapse, with a hazard ratio (HR) of 1.6 (p = 0.039), but without significant differences in overall survival (HR 1.29, p = 0.37). Although cytoplasmic overexpression of TIMP-1 protein was not correlated with early relapse (HR 1.2, p = 0.35), high expression was associated with shorter overall survival (HR 1.73, p = 0.027). In multivariate analysis, when considering stage, histologic grade, hormonal and HER2 status, TIMP-1 RNA levels remained independently prognostic for early relapse (HR 1.68, p = 0.04). Discussion: Elevated TIMP-1 RNA levels are independently prognostic for early recurrence, whereas protein overexpression of TIMP-1 is correlated with short overall survival in primary breast cancer. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P4-09-26.