tbuckley/cabot-search huggingface dataset:
TCT-497 A Novel Scoring System Predicting Major Adverse Cardiac Events in Coronary Artery Spasm Patients: A Large-scale Simulation Analysis
Authors: Jun Hyuk Kang, Seung-Woon Rha, Byoung Geol Choi, Jae Kyeong Byun, Se Yeon Choi, Woo Hyeun Kim, Ja Yeon Choi, James Hall, Sung Hun Park, SunKi Lee, Hu Li, Jin Oh Na, Cheol Ung Choi, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong-Seog Seo, Dong Joo Oh
Journal: Journal of the American College of Cardiology (2016)
Association of beta‐blocker treatment with mortality following myocardial infarction in patients with chronic obstructive pulmonary disease and heart failure or left ventricular dysfunction: a propensity matched‐cohort analysis from the High‐Risk Myocardial Infarction Database Initiative
Authors: Stefano Coiro, Nicolas Girerd, Patrick Rossignol, João Pedro Ferreira, Aldo Maggioni, Bertram Pitt, Isabella Tritto, Giuseppe Ambrosio, Kenneth Dickstein, Faiez Zannad
Journal: European Journal of Heart Failure (2016)
TCT-10 Physiological testing of coronary artery stenosis by computation of invasive coronary angiography. The wire-free functional imaging (WIFI-II) study
Authors: Jelmer Westra, Shengxian Tu, Louise Nissen, Mai-Britt Vestergaard, Birgitte Krogsgaard Andersen, Emil Holck, Lene Nyhus Andreasen, None Yimin zhang, Steen Dalby Kristensen, Lars Romer Krussell, Christian Terkelsen, Johan Reiber, Jens Flensted Lassen
Journal: Journal of the American College of Cardiology (2016)
TCT-640 Percutaneous Mitral Valve Annuloplasty Patients with Minimal Acute Reduction in Mitral Regurgitation Improve Long Term (from the TITAN II trial)
Authors: Horst Sievert, Steven Goldberg, Tomasz Siminiak, Hubertus Degen, Janusz Lipiecki, Michael Haude
Journal: Journal of the American College of Cardiology (2016)
TCT-792 Non-Invasive Hemodynamics Poorly Predict Disease Severity and Response to Endovascular Therapy in Patients with Critical Limb Ischemia
Authors: Jihad Mustapha, Michael Jaff, George Adams, Larry Diaz, Robert Beasley, Theresa McGoff, Sara Finton, Carmen Heaney, Larry Miller, Fadi Saab
Journal: Journal of the American College of Cardiology (2016)
Notch1 Provides a Proliferative Signal in Mouse T Cell Leukemia by Directly Targeting c-Myc.
Authors: Kyle M. Draheim, Vishva M. Sharma, Jennifer A. Calvo, Leslie A. Cunningham, Nicole Hermance, Veena Krishnamoorthy, Levi Beverly, Manoj Bhasin, Anthony Capobianco, Michelle A. Kelliher
Journal: Blood (2006)
PANCREATICOGASTROSTOMÍA GUIADA POR ECOENDOSCOPIA: ANÁLISIS DE SU EFICACIA Y MANEJO EVOLUTIVO
Authors: JJ Vila, M Pérez-Miranda, J Gornals, E Vázquez-Sequeiros, JR Aparicio, I Fernández-Urién, R Sánchez-Ocaña, CF Consiglieri, J Carrascosa, M Cimavilla
Journal: Endoscopy (2016)

Introducción: La pancreaticogastrostomía (PG) y pancreaticoduodenostomía (PD) guiadas por ecoendoscopia permiten el drenaje transparietal del conducto pancreático cuando no es posible por vía transpapilar.
PS01.37: Comparison Between Sanger Sequencing and ARMS qPCR Method for EGFR Gene Mutation Detection of Non–Small Cell Lung Cancer
Authors: Jiexia Zhang, Xiaoshun Shi, Di Cai, Xiaoxiang Li, Zhuolin Wu, Ying Liang, Haiyun Mo, Jianxing He
Journal: Journal of Thoracic Oncology (2016)
TCT-723 Impact of Implantation Depth on Pacemaker Rate and Paravalvular Leakage after Balloon-Expandable Transcatheter Aortic Valve Implantation (Edwards Sapien 3)
Authors: Suzanne Fateh-Moghadam, Benita Grossmann, Sabrina Voesch, Martin Steeg, Wolfgang Bocksch
Journal: Journal of the American College of Cardiology (2016)
Octamer 4/microRNA‐1246 signaling axis drives Wnt/β‐catenin activation in liver cancer stem cells
Authors: Stella Chai, Kai‐Yu Ng, Man Tong, Eunice Y. Lau, Terence K. Lee, Kwok Wah Chan, Yun‐Fei Yuan, Tan‐To Cheung, Siu‐Tim Cheung, Xiao‐Qi Wang, Nathalie Wong, Chung‐Mau Lo, Kwan Man, Xin‐Yuan Guan, Stephanie Ma
Journal: Hepatology (2016)

Wnt/β‐catenin signaling is activated in CD133 liver cancer stem cells (CSCs), a subset of cells known to be a root of tumor recurrence and therapy resistance in hepatocellular carcinoma (HCC). However, the regulatory mechanism of this pathway in CSCs remains unclear. Here, we show that human microRNA (miRNA), miR‐1246, promotes cancer stemness, including self‐renewal, drug resistance, tumorigencity, and metastasis, by activation of the Wnt/β‐catenin pathway through suppressing the expression of AXIN2 and glycogen synthase kinase 3β (GSK3β), two key members of the β‐catenin destruction complex. Clinically, high endogenous and circulating miR‐1246 was identified in HCC clinical samples and correlated with a worse prognosis. Further functional analysis identified octamer 4 (Oct4) to be the direct upstream regulator of miR‐1246, which cooperatively drive β‐catenin activation in liver CSCs. Conclusion : These findings uncover the noncanonical regulation of Wnt/β‐catenin in liver CSCs by the Oct4/miR‐1246 signaling axis, and also provide a novel diagnostic marker as well as therapeutic intervention for HCC. (H epatology 2016;64:2062‐2076).
Does Baseline Health-Related Quality of Life or Symptom Burden Predict Clinical Outcomes in Patients with Newly Diagnosed CML-CP Treated with Nilotinib or Imatinib?
Authors: Jennifer L Beaumont, Cindy Nowinski, John Coombs, Tomasz Szczudlo, Rick E. Blakesley, Neil J. Gallagher, James Burns, David Cella
Journal: Blood (2011)
TCT-15 Use of Antegrade Dissection Re-entry in Coronary Chronic Total Occlusion Percutaneous Coronary Intervention in a Contemporary Multicenter Registry
Authors: Barbara Anna Danek, Aris Karatasakis, Dimitri Karmpaliotis, Khaldoon Alaswad, Robert Yeh, Farouc Jaffer, Mitul Patel, John Bahadorani, William Lombardi, R. Michael Wyman, J. Aaron Grantham, Anthony Doing, David Kandzari, Nicholas Lembo, Santiago Garcia, Catalin Toma, Jeffrey Moses, Ajay Kirtane, Manish Parikh, Ziad Ali, Judit Karacsonyi, Aya Alame, Phuong-Khanh Nguyen-Trong, Jose Roberto Martinez-Parachini, Pratik Kalsaria, Bavana Rangan, Craig Thompson, Subhash Banerjee, Emmanouil Brilakis
Journal: Journal of the American College of Cardiology (2016)
OFD1-Mediated T Cell Responses in MGUS Patients: Implications for Immunotherapy.
Authors: Simona Blotta, Rao Prabhala, Dheeraj Pelluru, Sasada Tetsuro, Brunella Franco, Pierosandro Tagliaferri, Pierfranceso Tassone, Kenneth C. Anderson, Nikhil C. Munshi
Journal: Blood (2007)
TCT-462 Efficacy and Safety of Biodegradable Polymer Everolimus-eluting stents versus Durable Polymer Biolimus-eluting stents: A direct comparison meta-analysis of 8,476 patients from randomized trials
Authors: Chirag Bavishi, SAURAV CHATTERJEE, Janine Pöss, Pedro Moreno
Journal: Journal of the American College of Cardiology (2016)
The genomic landscape of core-binding factor acute myeloid leukemias
Authors: Zachary J Faber, Xiang Chen, Amanda Larson Gedman, Kristy Boggs, Jinjun Cheng, Jing Ma, Ina Radtke, Jyh-Rong Chao, Michael P Walsh, Guangchun Song, Anna K Andersson, Jinjun Dang, Li Dong, Yu Liu, Robert Huether, Zhongling Cai, Heather Mulder, Gang Wu, Michael Edmonson, Michael Rusch, Chunxu Qu, Yongjin Li, Bhavin Vadodaria, Jianmin Wang, Erin Hedlund, Xueyuan Cao, Donald Yergeau, Joy Nakitandwe, Stanley B Pounds, Sheila Shurtleff, Robert S Fulton, Lucinda L Fulton, John Easton, Evan Parganas, Ching-Hon Pui, Jeffrey E Rubnitz, Li Ding, Elaine R Mardis, Richard K Wilson, Tanja A Gruber, Charles G Mullighan, Richard F Schlenk, Peter Paschka, Konstanze Döhner, Hartmut Döhner, Lars Bullinger, Jinghui Zhang, Jeffery M Klco, James R Downing
Journal: Nature Genetics (2016)
TCT-284 Interrelationship between depression, angina, and dyspnea before and after CTO PCI in the OPEN CTO Registry
Authors: Farouc Jaffer, J. Aaron Grantham, James Sapontis, John Spertus, Kensey Gosch, Philip Jones, Jeffrey Bruckel, William Lombardi, Robert Yeh
Journal: Journal of the American College of Cardiology (2016)
CCG is criticised for paying private firm to screen referrals
Authors: Gareth Iacobucci
Journal: BMJ (2016)

The BMA has warned cash strapped clinical commissioning groups that they risk repeating the mistakes of the past if they seek to make financial savings by restricting GPs’ referrals to specialist care.

The warning came after concerns were raised about a new scheme in the north east of England where a private company is being paid to screen all GP referrals for cardiology, gynaecology, dermatology, ear, nose, and throat, gastroenterology, and ophthalmology care.

The rapid specialist opinion scheme, commissioned by North Durham Clinical Commissioning Group, is diverting all GP referrals in these specialties to be scrutinised by the private company About Health as part of an effort to save money by reducing …
TCT-309 CLINICAL IMPACT OF CHRONIC TOTAL OCCLUSIONS IN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION OF UNPROTECTED LEFT MAIN DISEASE
Authors: Alejandro Gutierrez-Barrios, Dolores Cañada, Enrique Diaz-Retamino, Dolores Ruiz, Antonio Agarrado, Sergio Gamaza, Miguel Alba, Manuel J. Oneto
Journal: Journal of the American College of Cardiology (2016)
Phase II Study of a Novel Reduced Toxicity Preparative Regimen for Hematopoietic Cell Allografting Combining Pentostatin (Nipent) and Targeted Doses of Intravenous Busulfan (Busulfex) with or without Rituximab (PB±R) Using a Novel Principle of CD4-Guided Immune Suppression
Authors: Mohamed A Kharfan-Dabaja, Claudio Anasetti, Nathalie Luis, Linda Brand, Janelle Perkins, Hugo F. Fernandez, Jose Leonel Ochoa-Bayona, Taiga Nishihori, Lia E Perez, Ernesto Ayala, Javier Pinilla-Ibarz, Lubomir Sokol, Joseph Pidala, Frederick L Locke, Eduardo M. Sotomayor, Teresa Field, Marcie Tomblyn
Journal: Blood (2011)
Non-Gastric Advanced MALT Lymphoma Demonstrated Worse Prognosis Than Gastric MALT Lymphoma Even Treated by Rituximab-Combined chemotherapy.
Authors: Kyoko Ueda, Yasuhito Terui, Masahiro Yokoyama, Sakura Sakajiri, Yuko Mishima, Noriko Nishimura, Kenji Nakano, Eriko Nara, Kazuhito Suzuki, Kentaro Nasu, Shunji Takahashi, Kengo Takeutchi, Kiyohiko Hatake
Journal: Blood (2010)
TCT-676 Prevalence of Residual Mitral and Tricuspid Regurgitation (MR/TR) following Transcatheter Aortic Valve Replacement (TAVR): Residual Mod/Severe MR and TR is Associated with Higher Mortality post TAVR
Authors: John Schindler, Joao Cavalcante, Andrew Althouse, Michael S. Sharbaugh, Dustin Kliner, William Katz, Matthew E. Harinstein, Frederick W. Crock, Forozan Navid, Joon Lee, Thomas Gleason
Journal: Journal of the American College of Cardiology (2016)
Block Excision of Iridociliary Tumors Enables Molecular Profiling and Immune Vaccination
Authors: Ludwig M. Heindl, Konrad R. Koch, Manuel M. Hermann, Sabine Merkelbach-Bruse, Anne M. Schultheis, Svenja Wagener, Reinhard Büttner, Cornelia Mauch, Beatrice Schuler-Thurner, Gerold Schuler, Claus Cursiefen
Journal: Ophthalmology (2016)
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions
Authors: Stephen P. Burr, Ana S.H. Costa, Guinevere L. Grice, Richard T. Timms, Ian T. Lobb, Peter Freisinger, Roger B. Dodd, Gordon Dougan, Paul J. Lehner, Christian Frezza, James A. Nathan
Journal: Cell Metabolism (2016)

Hypoxia-inducible transcription factors (HIFs) control adaptation to low oxygen environments by activating genes involved in metabolism, angiogenesis, and redox homeostasis. The finding that HIFs are also regulated by small molecule metabolites highlights the need to understand the complexity of their cellular regulation. Here we use a forward genetic screen in near-haploid human cells to identify genes that stabilize HIFs under aerobic conditions. We identify two mitochondrial genes, oxoglutarate dehydrogenase (OGDH) and lipoic acid synthase (LIAS), which when mutated stabilize HIF1α in a non-hydroxylated form. Disruption of OGDH complex activity in OGDH or LIAS mutants promotes L-2-hydroxyglutarate formation, which inhibits the activity of the HIFα prolyl hydroxylases (PHDs) and TET 2-oxoglutarate dependent dioxygenases. We also find that PHD activity is decreased in patients with homozygous germline mutations in lipoic acid synthesis, leading to HIF1 activation. Thus, mutations affecting OGDHC activity may have broad implications for epigenetic regulation and tumorigenesis.
TCT-359 ULnar artery Transient compression facilitating Radial Artery patent hemostasis (ULTRA): A novel technique to reduce radial artery occlusion
Authors: Michail Koutouzis, Christos Maniotis, Constantinos Andreou, Grigorios Avdikos, Andreas Tsoumeleas, Maria Angelaki, Zenon Kyriakides
Journal: Journal of the American College of Cardiology (2016)
TCT-730 A multicenter analysis of incidence and predictors for permanent pacemaker implantations and new conduction abnormalities with a novel self-expandable transcatheter heart valve
Authors: Costanza Pellegrini, Oliver Husser, Won Kim, Andreas Holzamer, Thomas Walther, Tobias Rheude, Teresa Trenkwalder, Jonathan Michel, Adnan Kastrati, Heribert Schunkert, Christof Burgdorf, Michael Hilker, Helge Möllmann, Christian Hengstenberg
Journal: Journal of the American College of Cardiology (2016)
Zero-fragment Nephrolithotomy: A Multi-center Evaluation of Robotic Pyelolithotomy and Nephrolithotomy for Treating Renal Stones
Authors: Ryan Swearingen, Akshay Sood, Rabii Madi, Zachary Klaassen, Ketan Badani, Jack S. Elder, Kyle Wood, Ashok Hemal, Khurshid R. Ghani
Journal: European Urology (2016)
PS01.60: Ph Ib/II, Trial of INC280 ± Erlotinib vs Platinum + Pemetrexed in Adult pts with EGFR-Mutated, cMET amplified, EGFR TKI Resistant, Advanced NSCLC
Authors: Igor I. Rybkin, Egbert Smit, Hans-Georg Kopp, Dong-Wan Kim, Alexander Spira, Alfredo Berruti, Dae Ho Lee, Noemí Reguart, Mikhail Akimov, Karl Schumacher, Allison Upalawanna, Matthew Squires, Daniel S.-W. Tan
Journal: Journal of Thoracic Oncology (2016)
O-020 Impact of surgical site experience on treatment outcomes of fixed-cT3 and cT4 rectal cancer patients in phase III study comparing preoperative radiochemotherapy and short-course radiotherapy with consolidation chemotherapy (Polish-II study)
Authors: L. Wyrwicz, W. Michalski, A. Rutkowski, J. Krynski, L. Zajac, M. Szczepkowski, W. Tarnowski, E. Kosakowska, M. Winiarek, W. Polkowski
Journal: Annals of Oncology (2016)
A viral strategy for targeting and manipulating interneurons across vertebrate species
Authors: Jordane Dimidschstein, Qian Chen, Robin Tremblay, Stephanie L Rogers, Giuseppe-Antonio Saldi, Lihua Guo, Qing Xu, Runpeng Liu, Congyi Lu, Jianhua Chu, Joshua S Grimley, Anne-Rachel Krostag, Ajamete Kaykas, Michael C Avery, Mohammad S Rashid, Myungin Baek, Amanda L Jacob, Gordon B Smith, Daniel E Wilson, Georg Kosche, Illya Kruglikov, Tomasz Rusielewicz, Vibhakar C Kotak, Todd M Mowery, Stewart A Anderson, Edward M Callaway, Jeremy S Dasen, David Fitzpatrick, Valentina Fossati, Michael A Long, Scott Noggle, John H Reynolds, Dan H Sanes, Bernardo Rudy, Guoping Feng, Gord Fishell
Journal: Nature Neuroscience (2016)
TCT-751 ONE-YEAR CLINICAL OUTCOMES ACCORDING TO ANTITHROMBOTIC REGIMEN AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
Authors: Giulio Stefanini, Giuseppe Bruschi, Anna Sonia Petronio, Cristina Giannini, Claudia Fiorina, Marianna Adamo, Paola Colombo, Azeem Latib, Mauro Agnifili, Arnaldo Poli, None claudia tamburino, Giuseppe Ferrante, None carla boschetti, Franco Fabbiocchi, Pietro Giudice, Bernhard Reimers
Journal: Journal of the American College of Cardiology (2016)
P0470 : Development of a novel IGRA assay to test T cell responsiveness to HBV antigens in whole blood of chronic hepatitis B patients
Authors: W. Dammermann, F. Bentzien, E.-M. Stiel, C. Kühne, S. Ullrich, J. Schulze zur Wiesch, S. Lüth
Journal: Journal of Hepatology (2015)
TCT-437 Clinical outcome of coronary bifurcation management with a “fully bioresorbable” technique. Results of the multicentre BBS study
Authors: Bernardo Cortese, Azeem Latib, Davide Piraino, LUCA TESTA, Alfonso Ielasi, Salvatore Geraci, Akihito Tanaka, Dario Buccheri, Roberto Adriano Latini, Pedro Leon Silva Orrego, Antonio Colombo
Journal: Journal of the American College of Cardiology (2016)
TCT-123 Impella 2.5 Support Protects Against Acute Kidney Injury in Patients Undergoing High-Risk Percutaneous Coronary Intervention
Authors: Michael Flaherty, Sadip Pant, Tyler Kilgore, Sujith Dassanayaka, John Loughran, Wasiq Rawasia, Allen Cheng, Buddhadeb Dawn, Carlo Bartoli
Journal: Journal of the American College of Cardiology (2016)
P0659 : Cytokine responses in chronic hepatitis B patients dosed with the nucleic-acid polymer REP2139-Ca
Authors: F. Stelma, A. Vaillant, L. Jansen, M.J. Sinnige, E.M. van Leeuwen, N.A. Kootstra, M. Bazinet, M. Al-Mahtab, H.W. Reesink
Journal: Journal of Hepatology (2015)
Ledipasvir plus sofosbuvir fixed-dose combination for 6 weeks in patients with acute hepatitis C virus genotype 1 monoinfection (HepNet Acute HCV IV): an open-label, single-arm, phase 2 study
Authors: Katja Deterding, Christoph D Spinner, Eckart Schott, Tania M Welzel, Guido Gerken, Hartwig Klinker, Ulrich Spengler, Johannes Wiegand, Julian Schulze zur Wiesch, Anita Pathil, Markus Cornberg, Andreas Umgelter, Caroline Zöllner, Stefan Zeuzem, Armin Papkalla, Kristina Weber, Svenja Hardtke, Heiko von der Leyen, Armin Koch, Dorothee von Witzendorff, Michael P Manns, Heiner Wedemeyer
Journal: The Lancet Infectious Diseases (2016)
The Spectrum of Epigenetic Mutations in Myeloma and Their Clinical Impact
Authors: Charlotte Pawlyn, Martin F Kaiser, Brian A Walker, Christopher P Wardell, Alexander Murison, David C Johnson, Lorenzo Melchor, Eileen M Boyle, John Jones, Dil Begum, Nasrin Dahir, Paula Proszek, David A Cairns, Walter Gregory, Gordon Cook, Roger G Owen, Mark T Drayson, Graham Jackson, Faith E Davies, Gareth J. Morgan
Journal: Blood (2014)
Disparities found in chemotherapy administration for human immunodeficiency virus‐associated lymphoma
Authors: Mary Kay Barton
Journal: CA A Cancer Journal for Clinicians (2016)

Key Points The drop in cases of HIV‐associated lymphoma from 2004 to 2012 was significantly larger among white non‐Hispanic patients than in the black or Hispanic population. The percentage of patients receiving chemotherapy for HIV‐associated lymphoma was not significantly different over the study period for the common types of NHL. Strategies to address disparities are being actively researched and implemented.
Very thin strut biodegradable polymer everolimus-eluting and sirolimus-eluting stents versus durable polymer zotarolimus-eluting stents in allcomers with coronary artery disease (BIO-RESORT): a three-arm, randomised, non-inferiority trial
Authors: Clemens von Birgelen, Marlies M Kok, Liefke C van der Heijden, Peter W Danse, Carl E Schotborgh, Martijn Scholte, R Melvyn Tjon Joe Gin, Samer Somi, K G van Houwelingen, M G Stoel, Frits H A F de Man, J (Hans) W Louwerenburg, Marc Hartmann, Paolo Zocca, Gerard C M Linssen, Job van der Palen, Carine J M Doggen, Marije M Löwik
Journal: The Lancet (2016)
TCT-761 Long-term (3-year) safety and effectiveness from the Global SYMPLICITY Registry of renal denervation in a real world patient population with uncontrolled hypertension
Authors: Felix Mahfoud, Nicole Brilakis, Michael Böhm, Krzysztof Narkiewicz, Luis Ruilope, Markus Schlaich, Giuseppe Mancia
Journal: Journal of the American College of Cardiology (2016)
The study of brain functional connectivity in Parkinson’s disease
Authors: Lin-lin Gao, Tao Wu
Journal: Translational Neurodegeneration (2016)

Parkinson's disease (PD) is a neurodegenerative disorder primarily affecting the aging population. The neurophysiological mechanisms underlying parkinsonian symptoms remain unclear. PD affects extensive neural networks and a more thorough understanding of network disruption will help bridge the gap between known pathological changes and observed clinical presentations in PD. Development of neuroimaging techniques, especially functional magnetic resonance imaging, allows for detection of the functional connectivity of neural networks in patients with PD. This review aims to provide an overview of current research involving functional network disruption in PD relating to motor and non-motor symptoms. Investigations into functional network connectivity will further our understanding of the mechanisms underlying the effectiveness of clinical interventions, such as levodopa and deep brain stimulation treatment. In addition, identification of PD-specific neural network patterns has the potential to aid in the development of a definitive diagnosis of PD.
TCT-538 Clinical characteristics of patients with discordant results for fractional flow reserve and instantaneous wave-flow ratio
Authors: Kensuke Matsushita, Kiyoshi Hibi, Yasushi Matsuzawa, Yuichiro Kimura, Nobuhiko Maejima, Noriaki Iwahashi, Anton Moritz, Toshiaki Ebina, Kazuo Kimura
Journal: Journal of the American College of Cardiology (2016)
Reduced intensity allogeneic stem cell transplantation in patients with myelodysplastic syndrome: Does the conditioning matter? A retrospective study of the SFGM-TC on 61 patients
Authors: L. Terriou, Z. Chir, H. Esperou, J. Boiron, N. Gratecos, J. Vernant, M. Michallet, N. Milpied, J. Jouet, I. Yakoub-Agha
Journal: Journal of Clinical Oncology (2006)

6547 Background: Reduced-intensity allogeneic stem cell transplantation (RIT) has emerged as an alternative to myeloablative transplantation in pts with myelodysplastic syndrome (MDS). Given the uncertainty regarding the appropriate conditioning, SFGM-TC conducted a retrospective multicenter study with the attempt to evaluate the impact of conditioning on pts’ outcome. Methods: The record of 61 pts (37 males) with MDS who received a RIT between 1998 and 2003, from 22 French transplantation centres, were reviewed. According to the FAB classification, 11 pts had RA at diagnosis, of whom one had progressed to REAB and one to AML before transplantation. Thirty-two pts had REAB, of whom 2 had progressed to REAB-T and 7 to AML. Twelve pts had REAB-T and 6 CMML, of whom 8 progressed to AML. The median time from diagnosis to RIT was 12 months (6–129). Conditioning regimen consisted of fludarabin (Flu) plus busulfan ( n=29), Flu plus 2-Gy TBI ( n=20) and idarubicin plus aracytine and Flu (n=12). Donors were HLA-identical siblings (n=52) and HLA-matched unrelated (n=9). All pts received peripheral blood stem cells. The median of CD34+ infused cell dose was 5 × 10 6 /kg (0.5–17.3). Results: At the reference date of 1 July 2005, median follow-up was 44.7 months (21–85). Estimated 3-year overall survival (OS), progression free survival (PFS), relapse and transplant-relapse mortality (TRM) were 35%, 27%, 66% and 30%, respectively. Neither of the 3 conditioning regimens used had impact on pts’ outcome. In multivariable analyses, while acute III/IV grade GVHD development was the only factor found to adversely influencing OS (HR=3.6; 95% CI: 1.1–12.2), chronic GVHD development was the only favourably influencing PFS and relapse ratios (HR=0.3; 95% CI: 0.1–0.7 and HR=0.2; 95% CI: 0.1–0.6, respectively). TRM was adversely influenced by male sex of pt (HR=9.2; 95% CI: 1.5–66.6). Conclusions: RIT seems to be an effective treatment in MDS pts irrespective of conditioning type. While acute III/IV grade GVHD appeared to be detrimental, the benefit effect of chronic GVHD was to be bound to GVL effect. New approaches with focus on immunosuppressive treatment are needed to enhance the GVL effect with an acceptable risk of GVHD. No significant financial relationships to disclose.