tbuckley/cabot-search huggingface dataset:
Abstract P1-10-19: Skin, and nail, infections associated with the addition of pertuzumab to trastuzumab-based chemotherapy
Authors: JE Mortimer, Y Yuan, J Jung, L Kruper, D Stewart, S Chung, WK Yu, M Mendelsohn, M D'Apuzzo, B Tegtmeier, S Dadwal
Journal: Cancer Research (2016)

Abstract Objectives: We have maintained a local registry of skin and nail infections in patients receiving pertuzumab and trastuzumab as treatment for HER2 positive breast cancer. Over the past 16 months, we have continued to observe an increase in infectious complications in patients receiving the combination of pertuzumab and trastuzumab with or without chemotherapy. We expand a series of prospectively identified patients who developed infections while on these regimens. Methods: We became concerned about an increased incidence of infections shortly after the FDA approval of pertuzumab, and created an IRB approved registry of these patients. Results: Twenty-eight women were identified to have 32 separate infections (often at more than one site); 9 after cycle 1; 6 after cycle 2, 9 after cycle 3 and 8 after 4 or more cycles. The median age was 51 (Range 25-67); 14 received pertuzumab, trastuzumab, carboplatin, and docetaxel (PTCH), 5 pertuzumab, trastuzumab, and docetaxel, 7 pertuzumab, trastuzumab, and nab-paclitaxel, and 2 pertuzumab and trastuzumab. Folliculitis of the scalp, abdomen, and/or buttocks was observed in 19 patients, abscesses in 8 patients (4 of whom required incision and drainage) and cellulitis in 2. Severe paronychial infections involving one to 16 digits were observed in 4; 2 pt required surgical removal of 2 nails. Quantitative immunoglobulins were found to be low in 8 of 17 women tested; 2 patient had low total protein but did not have an assessment of quantitative immunoglobulins. All patients were initially treated with oral antibiotics, and 6 required hospitalization. Cultures were obtained in 10 patients; Staphylococcus aureus was identified in 4, methicillin resistant Staphylococcus aureus (MRSA) in 5, Enterococcus faecalis in 1. A 57 year old pt receiving neoadjuvant PTCH died on cycle 2 day 7. Autopsy was consistent with sepsis and gram positive cocci were identified. A 62 year old became septic and developed renal failure. Skin biopsies were performed in 3 patients and are consistent with changes associated with EGFR inhibition. Conclusions: We believe these infections are a result of combining pertuzumab with trastuzumab as 2 pts received no concurrent chemotherapy. An awareness of this complication is critical as some infections may be life-threatening. We have initiated patient education to ensure awareness of this potential complication. Citation Format: Mortimer JE, Yuan Y, Jung J, Kruper L, Stewart D, Chung S, Yu WK, Mendelsohn M, D'Apuzzo M, Tegtmeier B, Dadwal S. Skin, and nail, infections associated with the addition of pertuzumab to trastuzumab-based chemotherapy. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-10-19.
Enhanced brain-derived neurotrophic factor delivery by ultrasound and microbubbles promotes white matter repair after stroke
Authors: Berta Rodríguez-Frutos, Laura Otero-Ortega, Jaime Ramos-Cejudo, Patricia Martínez-Sánchez, Inés Barahona-Sanz, Teresa Navarro-Hernanz, María del Carmen Gómez-de Frutos, Exuperio Díez-Tejedor, María Gutiérrez-Fernández
Journal: Biomaterials (2016)
Human Growth Hormone and Albumin Metabolism in Patients with Cirrhosis
Authors: T G GABUZDA, H JICK, T C CHALMERS
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Human gamma delta T-cell receptor-positive cell-mediated inhibition of erythropoiesis in vitro in a patient with type I autoimmune polyglandular syndrome and pure red blood cell aplasia [see comments]
Authors: T Hara, Y Mizuno, M Nagata, Y Okabe, S Taniguchi, M Harada, Y Niho, K Oshimi, S Ohga, Y Yoshikai
Journal: Blood (1990)
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo
Authors: K. Otterdal, A. Portillo, E. Astrup, J.K. Ludviksen, C. Schjalm, D. Raoult, J.P. Olano, B. Halvorsen, J.A. Oteo, P. Aukrust, T.E. Mollnes, P.H. Nilsson
Journal: Clinical Microbiology and Infection (2016)
P1113 : Human Keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with JNK activation and protein adduct formation
Authors: N. Guldiken, Q. Zhou, O. Kucukoglu, M. Rehm, K. Levada, L.P. James, C. Trautwein, M. Bishr Omary, P. Strnad
Journal: Journal of Hepatology (2015)
Effect of Age on Nodule Induction by Azaserine and DNA Synthesis in Rat Pancreas 2 3
Authors: Daniel S. Longnecker, Janice French, Elisabeth Hyde, Herman S. Lilja, James D. Yager
Journal: JNCI Journal of the National Cancer Institute (1977)

Journal Article Effect of Age on Nodule Induction by Azaserine and DNA Synthesis in Rat Pancreas Get access Daniel S. Longnecker, Daniel S. Longnecker Search for other works by this author on: Oxford Academic PubMed Google Scholar Janice French, Janice French Search for other works by this author on: Oxford Academic PubMed Google Scholar Elisabeth Hyde, Elisabeth Hyde Search for other works by this author on: Oxford Academic PubMed Google Scholar Herman S. Lilja, Herman S. Lilja Search for other works by this author on: Oxford Academic PubMed Google Scholar James D. Yager, Jr. James D. Yager, Jr. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 58, Issue 6, June 1977, Pages 1769–1775, https://doi.org/10.1093/jnci/58.6.1769 Published: 01 June 1977 Article history Received: 30 August 1976 Accepted: 21 December 1976 Published: 01 June 1977
Monkeypox in the Western Hemisphere
Authors: Gregory D Huhn, Robert A Chase, Mark S Dworkin
Journal: New England Journal of Medicine (2004)

Vanderbilt University Nashville, TN 37232 james.crowe@vanderbilt.edu 1. Behrman RE, Kliegman RM, Arvin AM, eds. Nelson textbook of pediatrics. 15th ed. Philadelphia: W.B. Saunders, 1996. 2. Rudolph AM, ed. Rudolph’s pediatrics. 20th ed. Stamford, Conn.: Appleton & Lange, 1996. 3. Emerging and communicable diseases: surveillance and control. Geneva: World Health Organization, 1997. 4. Henrickson KJ, Hoover S, Kehl KS, Hua W. National disease burden of respiratory viruses detected in children by polymerase chain reaction. Pediatr Infect Dis J 2004;23:Suppl:S11-S18.
Extreme Heterogeneity Of Myeloablative Total Body Irradiation (TBI) Techniques Across Europe: A Survey Of Acute Leukemia Working Party Of The EBMT
Authors: Sebastian Giebel, Leszek Miszczyk, Krzysztof Slosarek, Leila Moukhtari, Fabio Ciceri, Jordi Esteve, Norbert Claude Gorin, Myriam Labopin, Arnon Nagler, Christoph Schmid, Mohamad Mohty
Journal: Blood (2013)
E1696: Final analysis of the clinical and immunological results of a multicenter ECOG phase II trial of multi-epitope peptide vaccination for stage IV melanoma with MART-1 (27–35), gp100 (209–217, 210M), and tyrosinase (368–376, 370D) (MGT) +/- IFNα2b and GM-CSF
Authors: J. M. Kirkwood, S. Lee, S. Land, C. Sander, R. Mascari, L. M. Weiner, T. L. Whiteside
Journal: Journal of Clinical Oncology (2004)

7502 Background: The role of peptides targeting multiple CD8 T cell epitopes of lineage antigens expressed in melanoma, and of systemic immunomodulators IFNα2b and GM-CSF have here been first evaluated in a multicenter cooperative group trial. Methods and Results: ECOG has completed accrual of 120 patients to a factorial 2 × 2 evaluation of vaccination q 2 weeks with three melanosomal peptides MGT, (A) alone, (B) +GM-CSF 250 mcg daily for 14/28 days each month or, (C) +IFNα2b10 MIU/M2 TIW (D) +both IFNα2b and GM-CSF. Candidates were PS 0,1 with normal organ functions, measurable disease and HLA-A2 expression. The primary endpoint of immune response has been measured by ELISPOT assay directly from the PBL without in vitro stimulation. Toxicities have been chiefly vaccine site discomfort, and expected IFNα2b and GM-CSF toxicity. ELISPOT assays are complete through month 3 for 71/120 cases. Immune response is documented in 26/71 evaluable pts (37%; 95% CI 25%–49%) with increase of ≥26 spots/50,000 T cells. At a median follow-up time of 12.7 mos, 11/26 pts with immune response have died, and median OS is 21.3 mos 95% CI (10.7, -). Among immunological nonresponders 28/45 died and median OS is 13.4 mos 95% CI (8.9, 16.5) p2=.046. Conclusions: Immune response to MGT was induced in 37% of pts with metastatic melanoma and immune response to vaccination correlates significantly with non-progression and survival in the first 70 pts of this study. Immune response to the peptides does not appear to be influenced by IFN α2b or GM-CSF given systemically at the dosages tested in this study, and the response to each peptide individually is presently under analysis. Supported by: NIH Grants CA23318, CA66636, CA21115, and awards to ECOG from Schering Plough and Immunex Corp. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Schering-Plough
The effect of blocking angiogenesis on anterior cruciate ligament healing following stem cell transplantation
Authors: Koji Takayama, Yohei Kawakami, Yutaka Mifune, Tomoyuki Matsumoto, Ying Tang, James H. Cummins, Nick Greco, Ryosuke Kuroda, Masahiro Kurosaka, Bing Wang, Freddie H. Fu, Johnny Huard
Journal: Biomaterials (2015)
A gp130 Interleukin-6 Transducer-Dependent SCID Model of Human Multiple Myeloma
Authors: Cosette Rebouissou, John Wijdenes, Patrick Autissier, Karin Tarte, Valerie Costes, Janny Liautard, Jean-Francois Rossi, Jean Brochier, Bernard Klein
Journal: Blood (1998)
Altered platelet alpha 2-adrenergic receptor binding sites in borderline personality disorder
Authors: S M Southwick, R Yehuda, E L Giller, B D Perry
Journal: American Journal of Psychiatry (1990)

The authors found significantly fewer total platelet alpha 2-adrenergic receptor binding sites in 13 nonmedicated patients with borderline personality disorder than in 11 patients with borderline personality disorder who were receiving low doses of benzodiazepines and 18 nonpsychiatric control subjects. The two patient groups showed comparable degrees of depression as assessed by the Hamilton Rating Scale for Depression. However, nonmedicated borderline patients were considerably more anxious than medicated patients, raising the possibility that lower alpha 2-adrenergic receptor binding in borderline personality disorder is related to anxiety.
Rabies in Europe in 2005
Authors: H Bourhy, L Dacheux, C Strady, A Mailles
Journal: Eurosurveillance (2005)

Rabies is still present in Europe in 2005. Its incidence in humans remains limited (fewer than 5 human cases per year) through the application of strict prophylactic measures (anti-rabies treatment) and by means of veterinary rabies control measures in the domesticated and wild animal populations. The main indigenous animal reservoirs are: the dog in eastern European countries and on the borders with the Middle East; the fox in central and eastern Europe; the racoon dog in northeastern Europe; and the insectivorous bat throughout the entire territory. Finally, each year, cases of animals with rabies imported from enzootic areas are reported, showing the permeability of borders and traveller’s lack of consideration of the rabies risk. These importations constantly threaten the rabies-free status of terrestrial animals in western European countries and complicate the therapeutic decisions taken by physicians in the absence of information regarding the biting animal.
Rapid response to the addition of lithium in iprindole-resistant unipolar depression: a pilot study
Authors: C de Montigny, R Elie, G Caillé
Journal: American Journal of Psychiatry (1985)

The authors administered lithium carbonate, 900 mg/day, in an open study to seven patients with a major unipolar depression refractory to 3-week treatment with iprindole, 90 mg/day, a tricyclic antidepressant devoid of any action on monoaminergic reuptake. All patients showed clinically significant improvement within 48 hours. Since iprindole induces in the animal a sensitization of forebrain neurons to serotonin (5-HT), as do other tricyclic antidepressants, and lithium enhances the activity of 5-HT neurons, the authors propose that an enhanced release of 5-HT on sensitized target neurons might underlie the rapid antidepressant effect in tricyclic-refractory depression when lithium is added to the treatment regimen.
(Alpha)alpha 5.3: a novel alpha(+)-thalassemia deletion with the breakpoints in the alpha 2-globin gene and in close proximity to an Alu family repeat between the psi alpha 2- and psi alpha 1-globin genes
Authors: G Lacerra, G Fioretti, M De Angioletti, L Pagano, E Guarino, C de Bonis, A Viola, G Maglione, A Scarallo, L De Rosa
Journal: Blood (1991)
Noninvasive <i>In Vivo</i> Imaging and Biologic Characterization of Thyroid Tumors by ImmunoPET Targeting of Galectin-3
Authors: Calogero D'Alessandria, Sten Braesch-Andersen, Kristel Bejo, Sybille Reder, Birgit Blechert, Markus Schwaiger, Armando Bartolazzi
Journal: Cancer Research (2016)

Abstract The high prevalence of thyroid nodules in the adult population and the relatively low incidence of thyroid cancer make the preoperative identification of malignant lesions challenging. The β-galactoside–binding protein galectin-3 is widely expressed in well-differentiated thyroid carcinomas, but not in normal thyrocytes and benign thyroid nodules. This molecule offers a candidate biomarker to improve thyroid cancer diagnosis. Here we report the development of an immunoPET approach for noninvasive imaging of thyroid cancer. The method employs a 89Zr-labeled mAb to galectin-3, which shows high specificity and binding affinity in vitro. Reliable and specific immunoPET imaging was obtained of thyroid cancer in vivo in murine xenograft models of human thyroid cancer. Our findings provide a method to improve the clinical management of patients with thyroid nodules while reducing unnecessary surgery and social costs. Cancer Res; 76(12); 3583–92. ©2016 AACR.
A Crisis in Late Pregnancy
Authors: John J. Ross, Akshay S. Desai, William A. Chutkow, Katherine E. Economy, G. William Dec
Journal: New England Journal of Medicine (2009)

A 31-year-old woman in the 37th week of pregnancy presented to the emergency room of another hospital with sudden onset of severe bitemporal headache and shortness of breath. She was in respiratory distress, which was made worse by lying flat, and reported that she felt as if she was drowning. Until the onset of these symptoms, her pregnancy had been uncomplicated, with normal . . .
Impact Of Dose-Density Delays In Diffuse Large B-Cell Lymphoma (DLBCL) Treated With R-CHOP21 Or R-CHOP14
Authors: Antonio Gutierrez, Antonia M Bautista-Gili, Leyre Bento, Ines Herraez, Lucia Garcia, Jordi Martinez-serra, Antonia Sampol, Rafael Ramos, Jordi Gines, Carmen Ballester, Albert Perez, Paloma Lopez-Perezagua, Jaime Daumal, Jose Rodriguez, Juan Besalduch
Journal: Blood (2013)
Late mortality after sepsis: propensity matched cohort study
Authors: Hallie C Prescott, John J Osterholzer, Kenneth M Langa, Derek C Angus, Theodore J Iwashyna
Journal: BMJ (2016)

To determine whether late mortality after sepsis is driven predominantly by pre-existing comorbid disease or is the result of sepsis itself. Observational cohort study. US Health and Retirement Study. 960 patients aged ≥65 (1998-2010) with fee-for-service Medicare coverage who were admitted to hospital with sepsis. Patients were matched to 777 adults not currently in hospital, 788 patients admitted with non-sepsis infection, and 504 patients admitted with acute sterile inflammatory conditions. Late (31 days to two years) mortality and odds of death at various intervals. Sepsis was associated with a 22.1% (95% confidence interval 17.5% to 26.7%) absolute increase in late mortality relative to adults not in hospital, a 10.4% (5.4% to 15.4%) absolute increase relative to patients admitted with non-sepsis infection, and a 16.2% (10.2% to 22.2%) absolute increase relative to patients admitted with sterile inflammatory conditions (P<0.001 for each comparison). Mortality remained higher for at least two years relative to adults not in hospital. More than one in five patients who survives sepsis has a late death not explained by health status before sepsis.
Current and Future Theranostic Applications of the Lipid-Calcium-Phosphate Nanoparticle Platform
Authors: Andrew B. Satterlee, Leaf Huang
Journal: Theranostics (2016)

Over the last four years, the Lipid-Calcium-Phosphate (LCP) nanoparticle platform has shown success in a wide range of treatment strategies, recently including theranostics.The high specific drug loading of radiometals into LCP, coupled with its ability to efficiently encapsulate many types of cytotoxic agents, allows a broad range of theranostic applications, many of which are yet unexplored.In addition to providing an overview of current medical imaging modalities, this review highlights the current theranostic applications for LCP using SPECT and PET, and discusses potential future uses of the platform by comparing it with both systemically and locally delivered clinical radiotherapy options as well as introducing its applications as an MRI contrast agent.Strengths and weaknesses of LCP and of nanoparticles in general are discussed, as well as caveats regarding the use of fluorescence to determine the accumulation or biodistribution of a probe.
Do dressings prevent infection of closed primary wounds after surgery?
Authors: Jane Blazeby
Journal: BMJ (2016)

#### What you need to know After surgery, the wound must try to heal. A dressing may be applied, with the expectation of improved healing, management of exudate, or reduced chance of surgical site infection. Surgical site infection is of particular importance to health services and patient outcomes. However, whether dressings are necessary and influence these issues is uncertain. Here we discuss uncertainty about wound dressings in closed primary surgical wounds. A closed primary surgical wound is formed when the skin edges of the surgical wound are approximated. Wounds may be closed with sutures or clips. Epithelisation and connective tissue deposition seal the join. The wound may then be covered with a dressing. Many different types are available (box 1).1 Tissue adhesive "glue" may also be added as a dressing to a closed wound (fig 1⇓). #### Box 1: Summary of dressings types (from the British National Formulary 1)
Case 24-1968
Authors: Jacob Lerman, Edward P. Richardson, Benjamin Castleman
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A sixty-nine-year-old man was admitted to the hospital because of jaundice and substernal pain.Except for pulmonary emphysema the patient had been well until six months previously, when he began to experience substernal burning pain. For forty years he had been drinking 2 to 4 glasses of whiskey every evening. During the two weeks before entry he noticed that the stools were light in color and frothy and that the urine was darker than usual. Subsequently, jaundice developed.On examination the patient was icteric. The anteroposterior diameter of the chest was increased, and coarse . . .
Abstract 2933: The apoptotic mechanism of action of SKI-178, a novel Sphingosine kinase 1 selective inhibitor
Authors: Taryn E. Dick, Jeremy Hengst, Vijay Kale, Ashley Colledge, Jong K. Yun
Journal: Cancer Research (2015)

Abstract We previously developed SKI-178 as a novel Sphingosine kinase 1 (SphK1) selective inhibitor that is cytotoxic toward a broad panel of cancer types. Herein, we sought to determine the mechanism-of-action of SKI-178-induced cell death. We present evidence that SKI-178 induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. Further examination of the mechanism-of-action (MOA) of SKI-178 implicated c-Jun NH2-terminal kinase (JNK) and cyclin-dependent protein kinase 1 (CDK1) as critical factors required for SKI-178-induced apoptosis. In cell cycle synchronized human AML cell lines, we demonstrate that entry into mitosis is required for apoptotic induction by SKI-178 and that CDK1, not JNK, is required for SKI-178-induced apoptosis. We further demonstrate that the sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178, leads to the simultaneous phosphorylation of the pro-survival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. Moreover, multi-drug resistance mediated by MDR-1 and/or pro-survival Bcl-2 family member over-expression did not affect the sensitivity of AML cells to SKI-178. In addition to AML, we extend the MOA of SKI-178 to include various solid tumor cell lines, including pancreatic cancer and glioblastoma. Taken together, we provide evidence that SKI-178 induces apoptosis in a CDK1-dependent manner and is not a substrate for MDR1, making it a promising chemotherapeutic candidate for the treatment of various cancer types, including those known to be drug resistant. Citation Format: Taryn E. Dick, Jeremy Hengst, Vijay Kale, Ashley Colledge, Jong K. Yun. The apoptotic mechanism of action of SKI-178, a novel Sphingosine kinase 1 selective inhibitor. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2933. doi:10.1158/1538-7445.AM2015-2933
Tricyclic-antidepressant-induced delirium and plasma drug concentration
Authors: S H Preskorn, S Simpson
Journal: American Journal of Psychiatry (1982)

Fourteen patients receiving routine doses of amitriptyline developed plasma drug concentrations above 300 ng/ml. Of the 7 patients with plasma levels above 450 ng/ml, 6 developed a drug-induced delirium as opposed to none of the 7 with levels below 450 ng/ml. Thus, this adverse effect could be avoided by monitoring levels and reducing dosage when appropriate.