tbuckley/cabot-search huggingface dataset:
Short notice access to GPs reduces emergency hospital visits, study shows
Authors: Jacqui Wise
Journal: BMJ (2016)

Improving the availability of appointments and opportunities to speak to a GP or nurse at short notice may help to reduce attendance at emergency departments, shows a large study that included nearly all general practices in England.

The research study, published in Emergency Medicine ,1 also found that greater use of alternative services such as walk-in centres or minor injury units was associated with reduced attendance at emergency departments.

The researchers …
Interferon-Inducible Protein 16 (IFI-16) Is Upregulated In Chronic Myeloid Leukemia (CML) and Is Involved In Oncogene-Induced Senescence
Authors: Clémentine Bouneau, Marie Laure Bonnet, Marie Claude Meunier, Djamel Aggoune, Fatima Dkhissi, François Guilhot, Annelise Bennaceur-Griscelli, Jean-Claude Chomel, Ali G Turhan
Journal: Blood (2013)
Effect of Concentration of Benzopyrene in Skin Carcinogenesis
Authors: E. L. Wynder, Lois Fritz, Natalie Furth
Journal: JNCI Journal of the National Cancer Institute (1957)

Journal Article Effect of Concentration of Benzopyrene in Skin Carcinogenesis Get access E. L. Wynder, E. L. Wynder Search for other works by this author on: Oxford Academic PubMed Google Scholar Lois Fritz, Lois Fritz Search for other works by this author on: Oxford Academic PubMed Google Scholar Natalie Furth Natalie Furth Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 19, Issue 3, September 1957, Pages 361–370, https://doi.org/10.1093/jnci/19.3.361 Published: 01 September 1957 Article history Received: 03 April 1957 Published: 01 September 1957
Remove policies that restrict access to opioids in developing countries, says report
Authors: Sophie Cousins
Journal: BMJ (2015)

The global community must take concrete action to tackle the major gap in access to controlled drugs in low and middle income countries, particularly opioids for pain relief, a new report has said.1

The Global Commission on Drug Policy, which campaigns for reducing the harm caused by drugs, said that drug control systems were a major barrier to access to opioids in these countries. It called for a new global initiative, led by the World Health Organization, to be developed to ensure access to controlled drugs by removing domestic and international obstacles.

Michel Kazatchkine, the UN secretary general’s special envoy on HIV/AIDS in eastern Europe and central Asia and a member of the commission, told The BMJ that 150 of 190 countries—or 5.5 billion people—had very little or no access …
A Statistical Model for Predicting Neutropenic Fever
Authors: Ariel Nelson, Dan Eastwood, Tao Wang, Karen Carlson, Laura C Michaelis, Marcelo C. Pasquini, Parameswaran N. Hari, Christopher R. Chitambar, Timothy S. Fenske, Mary Beth Graham, Mehdi Hamadani, Anita D'Souza, Ehab Atallah
Journal: Blood (2014)
Suicide by Anaphylaxis Attempted With Penicillin
Authors: Bryce Templeton
Journal: JAMA (1965)

To the Editor:—  While I was serving as a psychiatrist at the Federal Correctional Institution, Lompoc, Calif, a young male prisoner reported to me that he had once attempted suicide by coaxing a physician into giving him penicillin to which he had previously had an allergic reaction. In a review of publications about anaphylactic reactions, I was able to find no report either of a suicidal attempt by anaphylaxis or of consideration of this possibility by investigators.  The patient was a 21-year-old white male prisoner whom the guards brought to the prison hospital after discovering lacerations on the inner aspect of his wrist. The inmate reported that he had wanted to kill himself, although he was only mildly depressed. During one interview, he stated that he was allergic to penicillin and described an illness resembling serum sickness following an injection of penicillin. He further stated that some months after the
Cap, hood, cuff, and balloon – what next for colonoscopy?
Authors: Noor Mohammed, Bjorn Rembacken
Journal: Endoscopy (2015)

We read with great interest the paper by Gralnek et al. [1] on the use of balloon colonoscopy. This is yet another invention that aims to improve the adenoma detection rate (ADR) during colonoscopy. We would like to make a few comments about the paper.
Novel coronavirus associated with severe respiratory disease: Case definition and public health measures
Authors: N Danielsson, collective on behalf of the ECDC Internal Response Team, M Catchpole
Journal: Eurosurveillance (2012)

Two cases of rapidly progressive acute respiratory infection in adults associated with a novel coronavirus have generated an international public health response. The two infections were acquired three months apart, probably in Saudi Arabia and Qatar. An interim case definition has been elaborated and was published on the World Health Organization website on 25 September 2012.
LG-56NON-INFILTRATING LOW GRADE GLIOMA (LGG) OF THE BRAIN STEM IN CHILDREN. ONE CENTER EXPERIENCE
Authors: Monika Drogosiewicz, Ewa Swieszkowska, Iwona Filipek, Marta Perek-Polnik, Elżbieta Jurkiewicz, Paweł Daszkiewicz, Wiesława Grajkowska, Bozenna Dembowska-Baginska
Journal: Neuro-Oncology (2016)
Amenorrhea after the pill. [Letter]
Authors: Camilleri Ap
Journal: BMJ (1972)

The British Medical Journal takes some weeks to reach Malta so allow me to refer to your interesting leading article on amenorrhea after the pill (November 27 1971 p. 510).  I think that apart from amenorrhea there is an important related risk which is not adequately realized by medical practitioners.  It is the hazard of prolonged anovulation following long-term use of the pill in adolescence.  I read a communication on this subject at the 19th British Congress of Obstetrics and Gynaecology held in Dublin in May 1971.  In my series of 37 women treated for anovulatory infertility it was found that the group who had received no pill in adolescence or else did so for less than 6 months were much more readily responsive to treatment than the group who had been given the pill in adolescence for 6 months or more.  In the former group of 19 women 15 responded to clomiphene and the remaining 4 to Pergonal (human follicle-stimulating hormone).  In the other group of 18 women only 7 responded to clomiphene then 3 to Pergonal but 8 were still anovulatory.  The pill is widely prescribed to adolescent girls either as a contraceptive or else to provide a facile remedy for dysmenorrhea or irregular menstruation.  It should be prescribed with great caution at this age because it may seriously impair the subsequent resumption of regular ovulation with a consequent liability to infertility.  In fact it is probably contraindicated when there is a history of oligomenorrhea or of irregularity in the menstrual cycle.  (Full text)
Epidemiological analysis of mosquito-borne Pogosta disease in Finland, 2009
Authors: J Sane, S Guedes, S Kurkela, O Lyytikäinen, O Vapalahti
Journal: Eurosurveillance (2010)

Pogosta disease is a viral disease caused by a mosquito-borne alphavirus, Sindbis virus (SINV), and large human outbreaks of SINV infection have emerged in Finland every seven years. After a major outbreak in 2002 an epidemic was expected to take place in 2009. Data from the National Infectious Disease Registry showed a small outbreak in humans in 2009 with a total of 105 reported cases but the seven-year cycle did not recur as anticipated.
HG-97PAEDIATRIC GBM AND DIPG SUBCLONES CO-OPERATE TO PROMOTE TUMORIGENESIS
Authors: Mara Vinci, Anna Burford, Valeria Molinari, Sergey Popov, Kathryn R. Taylor, Helen Pemberton, Christopher J. Lord, Alice Gutteridge, Tim Forshew, Lynley V. Marshall, Elizabeth Y. Qin, Wendy J. Ingram, Andrew S. Moore, Hong Kong Ng, Saoussen Trabelsi, Dorra H'mida-Ben Brahim, Stergios Zacharoulis, Sucheta Vaidya, Henry C. Mandeville, Leslie R. Bridges, Andrew J. Martin, Safa Al-Sarraj, Christophe Chandler, Mariona Sunol, Jaume Mora, Carmen de Torres, Ofelia Cruz, Angel M. Carcaboso, Michelle Monje, Alan Mackay, Chris Jones
Journal: Neuro-Oncology (2016)
Orienting therapists about patients' needs to increase patient satisfaction
Authors: J Yamamoto, F X Acosta, L A Evans, W M Skilbeck
Journal: American Journal of Psychiatry (1984)

Twenty-nine psychotherapists received orientation about patients' cultural background, expectations, and therapeutic needs. They treated 98 patients before orientation and 73 afterward, and a follow-up interview was conducted 4-6 weeks after completion of therapy. The patients seen after therapist orientation were more satisfied with the services, felt better able to handle problems, were more likely to seek therapy for future problems, and felt more strongly that their needs for clinic services had been met than the patients seen by therapists before orientation. Analyses of therapist experience, patients' ethnicity, and patients' orientation to psychotherapy showed no significant interactions with patient satisfaction.
Correspondence
Authors: Ravi Jhaveri, Nancy Murray
Journal: Hepatology (2007)

We would like to point out an omission in the AASLD Practice Guidelines on Chronic Hepatitis B published in the February 2007 issue of HEPATOLOGY.1 In the section discussing the counseling and prevention of hepatitis B on pages 508-509 and in the accompanying table (Table 3), when discussing infants born to hepatitis B virus (HBV)-infected mothers, the authors neglected to discuss the issue of breast-feeding. This is certainly worth mentioning because some mothers feel breast-feeding to be an integral part of the care they provide to their infants, and mothers prohibited from breast-feeding may feel some sense of inadequacy. As you know, breast-feeding is not prohibited in HBV-infected mothers, as proven by several studies, some of which are listed here.2-4 Furthermore, because infants should routinely receive HBV immune globulin and HBV vaccine, they are almost universally protected against postpartum maternal HBV transmission. We think an additional 1-2 sentences should be included in the guidelines to address this issue. Ravi Jhaveri*, Nancy Murray , * Division of Infectious Diseases, Duke Children's Hospital, Durham, NC, Duke Children's Primary Care, Duke Children's Hospital, Durham, NC.
Analysis of Risk Factors for Patient Readmission 30 Days Following Discharge From General Surgery
Authors: Lisa K. McIntyre, Saman Arbabi, Ellen F. Robinson, Ronald V. Maier
Journal: JAMA Surgery (2016)

Previous studies investigating patients at risk for hospital readmissions focus on medical services and have found chronic conditions as contributors. Little is known, however, of the characteristics of patients readmitted from surgical services.Surgical patients readmitted within 30 days following discharge were analyzed to identify opportunities for intervention in a cohort that may differ from the medical population.Medical record review of patients readmitted to any service within 30 days of discharge from the general surgery service to characterize index and readmission data between July 1, 2014, and June 30, 2015, at a Level I trauma center and safety-net hospital.Reasons for readmission identified by manual medical record review and risk factors identified via statistical analysis of all discharges during this period.One hundred seventy-three patients were identified as being unplanned readmissions within 30 days among 2100 discharges (8.2%). Of these 173 patients, 91 were men. Common reasons for readmission included 29 patients with injection drug use who were readmitted with soft tissue infections at new sites (16.8% of readmissions), 25 with disposition support issues (14.5%), 23 with infections not detectable during index admission (13.3%), and 16 with sequelae of their injury or condition (9.2%). Sixteen patients were identified as having a likely preventable complication of care (9.2%), and 2 were readmitted owing to deterioration of medical conditions (1.2%). On univariate and multivariate analyses, female sex (men to women risk of readmission odds ratio [OR], 0.5; 95% CI, 0.37-0.71; P < .001), presence of diabetes (OR, 1.7; 95% CI, 1.1-2.6; P = .009), sepsis on admission (OR, 1.7; 95% CI, 1.05-2.6; P = .03), or intensive care unit stay during index admission (OR, 1.7; 95% CI, 1.2-2.4; P = .002), as well as discharge to respite care (OR, 2.3; 95% CI, 1.2-4.5; P = .01) and payer status (Medicaid/Medicare compared with commercial OR, 2.0; 95% CI, 1.3-3.0; P = .002) , were identified as risk factors for readmission.Many readmissions may be unavoidable in our current paradigms of care. While medical comorbidities are contributory, a large number of readmissions were not caused by suboptimal medical care or deterioration of medical conditions but by confounding issues of substance abuse or homelessness. Identification of the highest risk cohort for readmission can allow more targeted intervention for similar populations with socially challenged patients.
Negative symptoms in Alzheimer's disease
Authors: W E Reichman, A C Coyne, S Amirneni, B Molino, S Egan
Journal: American Journal of Psychiatry (1996)

This study was undertaken to demonstrate that negative symptoms are prominent in patients with Alzheimer's disease and are distinct from depression.patients with Alzheimer's disease (N=24) and a group of cognitively intact older adults (N=26) were compared in terms of scores on the Scale for the Assessment of Negative Symptoms in Alzheimer's Disease.Negative symptoms were more severe in patients with Alzheimer's disease than in the healthy elderly comparison subjects. Among the patients with Alzheimer's disease, negative symptoms were correlated with dementia severity.Patients with Alzheimer's disease display little interest in self-care, work and household tasks, social and family activities, and emotional needs of others, despite an absence of depressive symptoms, positive symptoms, comorbid systemic illnesses, or medication exposure. Such negative symptoms may contribute to functional disability and thus complicate management of such patients.
Abstract 4146: Overexpression of C5a receptor becomes risk factor in gastric cancer
Authors: Takayoshi Kaida, Hidetoshi Nitta, Kota Arima, Hideaki Takeyama, Takaaki Higashi, Katunobu Taki, Hiromitsu Hayashi, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba
Journal: Cancer Research (2015)

Abstract Background: C5a is one of the important factors produced on complement pathway and a strong chemokine. There is emerging evidence that C5a is generated in the cancer microenvironment and C5a receptor (C5aR) is expressed in various cancer cells and associated with invasive ability in several cancer cells. However, the role of C5aR in gastric cancer (GC) is still mostly unknown. Aim: To investigate the clinical significance of C5aR expression in human GC. Method: 168 patients underwent gastrectomy after the diagnosis of gastric cancer from January 1st 2001 to December 31th 2009. C5aR-expression of GC cells was investigated in all 168 patients and was analyzed in regard to an association with clinicopathological factors and outcomes in the patients. Additionally, in vitro experiments were used to examine the proliferation and invasion of GC cells by using the GC cell lines that had high-expression of C5aR. Result: High-expression of C5aR was found in 55 patients (32.7%). High-expression of C5aR was significantly related to depth of invasion, stage, lymphatic and vascular invasion. Among the 146 patients with a tumor stage lower than stageIV, the 5-years recurrence-free and overall survival rates of patients in the high-expression of C5aR group were significantly lower than those in the low-expression of C5aR group (91.0% vs 52.4%, p = 0.007 and 87.2% vs 59.1%, p = 0.003, respectively). The high-expression of C5aR group had more frequently distant metastasis than the low-expression of C5aR group during the follow-up time, presenting itself mainly in liver metastasis and peritoneal dissemination (p = 0.020 and p = 0.026). We found that the gastric cancer cell lines MKN1 and MKN7 had the high-expression of C5aR with western blotting in vitro. Moreover, matrigel chamber assay revealed that 10 nM of recombinant C5a enhances cell invasiveness of MKN1 by 2.55-fold and the cell invasiveness of MKN7 by 2.90-fold, but such an enhancement by C5a was not observed in control cells. Conclusions: The gastric cancer patients with a high expression of C5aR were associated with poor prognosis, and the invasive ability of gastric cancer cell lines highly expressing of C5aR were promoted by C5a. Thus, targeting this C5a-C5aR axis might provide a useful therapeutic option for gastric cancer treatment. Citation Format: Takayoshi Kaida, Hidetoshi Nitta, Kota Arima, Hideaki Takeyama, Takaaki Higashi, Katunobu Taki, Hiromitsu Hayashi, Daisuke Hashimoto, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu, Hideo Baba. Overexpression of C5a receptor becomes risk factor in gastric cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4146. doi:10.1158/1538-7445.AM2015-4146
The WHO update on influenza A (H5N1) in Hong Kong
Authors: D Lavanchy
Journal: Eurosurveillance (1998)

In May 1997 influenza A subtype H5N1 virus was isolated in the Special Administrative Region of Hong Kong from a child who died. Until then, the H5N1virus was known to infect only various species of birds, including chickens and ducks. After the first hum
Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia
Authors: Daniela Capello, Umberto Vitolo, Laura Pasqualucci, Silvia Quattrone, Giuseppe Migliaretti, Lucia Fassone, Cristiano Ariatti, Daniela Vivenza, Annunziata Gloghini, Cristina Pastore, Carlo Lanza, Josep Nomdedeu, Barbara Botto, Roberto Freilone, Daniela Buonaiuto, Vittorina Zagonel, Eugenio Gallo, Giorgio Palestro, Giuseppe Saglio, Riccardo Dalla-Favera, Antonino Carbone, Gianluca Gaidano
Journal: Blood (2000)
The Precut - When, Where and How? A Review
Authors: P V J Sriram, G V Rao, D Nageshwar Reddy
Journal: Endoscopy (2003)

Gaining access to the biliary or pancreatic duct is the most important step for a successful therapeutic biliary pancreatic endoscopy. The overall success rate of cannulation ranges from 90 to 95 % even when performed by experts [1]. In about 5 to 10 % of cases, the common bile duct remains inaccessible necessitating ”precut” [2] [3] [4] [5]. Precut sphincterotomy is the Achilles’ heel of many an endoscopist and the ultimate tool in the biliary endoscopist’s armamentarium for gaining access across the papilla to facilitate biliary endotherapy. It is often considered to be ‘dangerous’, ‘complicated’ and to be reserved for the ‘experts’ [6]. Like any other interventional procedure, precut is associated with its attendant risks and morbidity, the most important complication being endoscopic retrograde cholangiopancreatography (ERCP) induced acute pancreatitis [7] [8] [9] [10] [11] [12] [13] [14]. This follows trauma and edema of the papilla due to multiple unsuccessful attempts and inadvertent pancreatic duct cannulations and precutting in such circumstances results in higher morbidity, especially when performed on undilated bile ducts [15] [16]. Hence, it is all the more important to teach and train the inexperienced about when, where, and how to do precut sphincterotomy. We have reviewed precutting with regard to its basis, technical aspects, and the available relevant literature.
Use of Trypsin in the Treatment of Experimental Coronary Thrombosis
Authors: CARL R. CONRAD, ARTHUR F. GEIS
Journal: Circulation Research (1958)

A method for the production of experimental coronary thrombosis in dogs by the injection of thrombin into the anterior descending branch of the left coronary artery is presented. The clot-dissolving properties of trypsin in the form of Tryptar and Enzar were evaluated. The effect of trypsin was also studied in relation to changes in the clotting mechanism of the blood for the purpose of determining tolerated doses. Regardless of amounts of enzyme or time of administration, there was no evidence to indicate prevention of myocardial infarction.
Tracing the expression of circular RNAs in human pre-implantation embryos
Authors: Yujiao Dang, Liying Yan, Boqiang Hu, Xiaoying Fan, Yixin Ren, Rong Li, Ying Lian, Jie Yan, Qingqing Li, Yan Zhang, Min Li, Xiulian Ren, Jin Huang, Yuqi Wu, Ping Liu, Lu Wen, Chen Zhang, Yanyi Huang, Fuchou Tang, Jie Qiao
Journal: Genome biology (2016)

PolyA– RNAs have not been widely analyzed in human pre-implantation embryos due to the scarcity of materials. In particular, circular RNA (circRNA), a novel type of polyA– RNA, has not been characterized during human pre-implantation development. We systematically analyze polyA+ messenger RNAs (mRNAs) and polyA– RNAs in individual human oocytes and pre-implantation embryos using SUPeR-seq. We de novo identify 10,032 circRNAs from 2974 hosting genes. Most of these circRNAs are developmentally stage-specific and dynamically regulated. Many of them are maternally expressed, implying their potentially important regulatory functions in oogenesis and the formation of totipotent zygotes. Comparison between human and mouse embryos reveals both high conservation and clear distinction between these two species. Human pre-implantation embryos generate more types of circRNA compared with mouse embryos and this is associated with a striking increase of the length of the circRNA flanking introns in humans. We also perform RNA de novo assembly and identify novel transcript units, many of which are potentially novel long non-coding RNAs. This study reports the first analysis of the whole transcriptome comprising both polyA+ mRNAs and polyA– RNAs including circRNAs during human pre-implantation development. It provides an invaluable resource for analyzing the unique function and complex regulatory mechanisms of circRNAs during this process.
[ 18 F]-NaF PET/CT Identifies Active Calcification in Carotid Plaque
Authors: Myra S. Cocker, J. David Spence, Robert Hammond, George Wells, Robert A. deKemp, Cheemun Lum, Adebayo Adeeko, Martin J. Yaffe, Eugene Leung, Andrew Hill, Sudhir Nagpal, Grant Stotts, Murad Alturkustani, Laurel Hammond, Jean DaSilva, Tayebah Hadizad, Jean-Claude Tardif, Rob S.B. Beanlands
Journal: JACC. Cardiovascular imaging (2016)