tbuckley/cabot-search huggingface dataset:
P280 Pulmonary rehabilitation (PR) for interstitial lung disease (ILD). do patients’ perceptions match functional outcomes?
Authors: L Stanley, C Cobbett, E Morris, D Gibson, SV Fletcher
Journal: Thorax (2016)

<h3>Introduction</h3> ILD refers to a group of fibrotic lung conditions that differ in terms of treatment, prognosis and association. The NICE quality statement (2015) supports PR for patients with IPF, the most common form of ILD. There is no clear guidance for delivery of PR to ILD patients, so current practice is to extrapolate from the benefits of PR in COPD (Spruit <i>et al</i>, 2013), despite the differing pathophysiology. <h3>Aim</h3> The focus of the study was to observe the patients’ perceptions of a modified ILD PR programme against functional and health related quantitative measures. <h3>Methods</h3> Patients were recruited to the program either by self-referral or by ILD clinicians. Seven participants were recruited. The 6-week PR program consisted of 60 minutes exercise and 30 minutes education with the emphasis on strength training over endurance. Focus group interviews were used to collect qualitative data and analysed using an inductive approach utiilising thematic analysis as a method. <h3>Results</h3> 7 patients completed the programme (5M:2F, mean age 73.4). Initial qualitative analysis demonstrates psychological benefit from the sharing of disease experiences, prioritising exercise as a means of management, empowerment and understanding. 6MWT and Kings Brief ILD questionnaire showed no significant change pre and post PR, see Table 1. These quantitative results do not reflect patient perceptions of improved functional status. <h3>Conclusion</h3> Patients perceptions were positive regarding the content and impact it had on their education needs concerning their disease. The predominant perceived benefit was that of the comradery found in sharing experiences with other ILD patients. No firm conclusions can be drawn from this study regarding the effectiveness of PR for patients with ILD due to small numbers. It is unclear whether the tools used to assess functional and health measures are suitable to detect changes in outcomes post PR or whether the effects of an ILD PR programme are predominantly that of disease management and education, explaining the disparity observed between quantitative and qualitative outcomes. Further appropriately powered controlled studies could examine the impact of PR and in particular that of PR education specifically for ILD patients, as supported by Holland <i>et al</i>. (2015).
Phase I study of low-dose hypomethylating agent azacitidine (5-AC) combined with the histone deacetylase inhibitor valproic acid (VPA) in patients with advanced cancers
Authors: F. Braiteh, A. Soriano, C. H. Luis, H. S. David, C. Ng, G. Garcia-Manero, R. Kurzrock
Journal: Journal of Clinical Oncology (2006)

3060 Background: By inhibiting DNA methyltransferase, 5-azacytidine (5-AC) reverses epigenetic silencing of aberrantly hyper-methylated genes restoring activity of tumor suppressor and pro-apoptotic genes. In leukemia, the responses achieved with the hypomethylating agent decitabine are considerably greater at low doses than at high dose levels. We explored the tolerance to a combination of valproic acid (VPA), a histone deacetylase inhibitor, given together with low-dose 5-AC and the ability of this combination to induce DNA hypomethylation. Methods: Every 28-day cycle, 5-AC was givenSC daily for 10 days, and VPA was administered orally daily in doses titrated up to therapeutic levels (75–100 mcg/mL). Planned dose-levels of 5-AC (6-patients/cohort) were determined per an adaptive algorithm based on toxicity in the previous cohort (toxicity-based adaptive dosing model (TAD model) with a starting dose of 20 mg/m 2 . The methylation status of long interspersed nuclear elements (LINE) was used as a surrogate marker of global methylation, and was performed on peripheral blood mononuclear cells on day 1 and 10 of the first 4 cycles for each patient. Results: To date, twenty-two patients have enrolled at 20, 25, 37.5 and 47 mg/m 2 dose-levels. The VPA dose was titrated up to 18.8 ± 6.9 mg/kg. Side effects include mainly drowsiness (N = 5), tremor (N = 4), hypomagnesemia (N = 2), grade 1–2 anemia (N = 2), and neutropenia (N = 2). One DLT (neutropenic fever) occurred at a dose of 37.5 mg/m 2 . One patient with rapidly progressive disease (renal cell carcinoma) experienced stable disease (6 months), and three patients (adenocystic carcinoma = 1, leiomyosarcoma of the uterus = 2) experienced stable disease for 4 months. Eighty-two blood samples were obtained. Median LINE methylation pretreatment was 65% (range 59–70%, it declined to 61% (range 53–63%) by day 10 (p = 0.001)and returned to baseline by day 0 of the following cycle. Conclusions: Our preliminary data suggest that low-dose 5-AC combined with VPA (median = 17 mg/kg) is well tolerated and exhibits biological activity in patients with advanced cancer. Western blot assays for histone acetylation are in process. The trial is currently accruing at dose-level 47 mg/m 2 . [Table: see text]
S31 Reproducibility of four challenge modalities for chronic cough
Authors: L Douglas, H Fowles, K Arnell, S Thackray-Nocera, A Morice
Journal: Thorax (2016)

<h3>Background</h3> Cough challenges are utilised in clinical research to help determine efficacy of treatments for cough. Recently adenosine triphosphate (ATP) has gained interest as a potential tussive agent. Previous research suggests such challenges are reproducible in healthy individuals, but little is known about their reproducibility in chronic cough patients, particularly the use of ATP as a tussive agent. This study aims to clarify if ATP is a reproducible tussive agent in chronic cough patients. <h3>Method</h3> Data was collected on subjects undergoing cough challenges in the clinical trials unit. Subjects performed tussive challenges with four agents (capsaicin, ATP, citric acid and fog) in a randomly allocated order (visit 1); C2 and C5 were noted. This test was then repeated a week later (visit 2). Intra-patient variability was analysed using the Bland-Altman method for each tussive agent, presented as mean difference (95% limits of agreement). Inter-patient variability was analysed using paired t-tests. Pearson’s correlation coefficient (r) between ATP and other agents was calculated. <h3>Results</h3> 26 subjects were recruited; 21 with chronic cough. Average age of 57.4 ± 12.2, mean BMI of 26.8 ± 5.7, with an 85% female predominance. ATP showed a strong correlation with citric acid (r = 0.76, p &lt; 0.001) and capsaicin (r = 0.66, p &lt; 0.001). Bland-Altman analysis at C5 showed a 95% limit of agreement to be more than a two log dose difference except for fog: citric acid −0.07 (−1.7 to 1.5), capsaicin −0.1 (−1.5 to 1.2), ATP −0.2 (−2.5 to 2.1) (Figure 1), fog −0.01 (−0.3 to 0.3). Comparing visit 1 and visit 2 for each tussive agent showed no significant difference (p-value of 0.58, 0.80, 0.90, and 0.80 for ATP, fog, capsaicin and citric acid, respectively). <h3>Conclusion</h3> ATP shows a strong correlation with other agents currently being utilised in cough challenges. This suggests direct cell surface activation similar to other agents. Comparing challenges in chronic cough patients shows that whilst inter-patient variability is low, intra-patient variability is high. Therefore, in contrast to healthy subjects, cough challenges are unlikely to be a useful measure of determining individual improvement in chronic cough patients.
P194 Early warning scores, too imprecise a tool in patients with respiratory disease?
Authors: S Forster, G Housley, J Hatton, D Shaw
Journal: Thorax (2016)

<h3>Introduction</h3> Guidance from the National Institute of Health and Care Excellence in 2007<sup>1</sup> has led to the almost universal use of early warning scores (EWS) derived from vital signs observations in hospitals in the UK to highlight patients at risk of deterioration. Lack of high quality prospective studies limits our understanding of the impact of using such monitoring systems on outcomes and working patterns. No EWS has been validated in respiratory patients despite widespread use. Our aim was to examine the ability of both the locally used EWS and National Early Warning Score (NEWS) to predict patient deterioration and associated burden of escalations generated in a respiratory cohort. <h3>Methods</h3> Vital signs observations and outcomes for all admissions under the respiratory department at a tertiary referral centre between April 2015 and March 2016 were analysed. Predicted and actual escalation patterns in relation to primary endpoint of mortality were examined comparing NEWS to local EWS. Patients documented as receiving end of life care were removed from analysis. <h3>Results</h3> Over 12 months there were 165,184 observations sets during 5293 admissions, with a mean of 38 observations per admission (standard deviation 50). Occurrence of primary endpoint of in-hospital death was 6.74%. 13% of observations triggered clinical escalation to a registered nurse or beyond, with mean of 1075 per month. 112 (31%) patients who died did not trigger escalation on their final set of observations, 1 patient was escalated despite scoring below protocol threshold. Applying NEWS criteria retrospectively predicts 6 patients who died would not be escalated, while generating a mean of 12,409 escalations of vital signs observations per month to registered nurse or beyond, 1,621 in patients who went on to die in hospital. <h3>Conclusion</h3> Our data suggests that neither scoring system provides effective monitoring in patients with respiratory disease, falling short on either sensitivity or specificity for predicting in-hospital death. As more data becomes available, modelling may allow more accurate prediction systems to be developed. <h3>Reference</h3> Adam S, <i>et al</i>. Acutely ill adults in hospital: recognising and responding to deterioration. In <i>NICE guidelines</i>. Manchester: National Institute for Health and Care Excellence (NICE), 2007.
Intrinsic Molecular Features of Human Hematopoietic Stem Cells from Different Sources Define Their Specific Functional Properties
Authors: Maria Rosa Lidonnici, Annamaria Aprile, Marta Frittoli, Giacomo Mandelli, Ylenia Paleari, Bernhard Gentner, Laura Bellio, Elena Cassinerio, Laura Zanaboni, Maria Domenica Cappellini, Fabio Ciceri, Sarah Marktel, Giuliana Ferrari
Journal: Blood (2015)
5-Azacytidine Before or After Stem Cell Transplantation in Acute Myeloid Leukaemia (AML) and Myelodysplastic Syndromes (MDS)
Authors: Ana Garrido, Miguel Ortín, Rodrigo Martino, Josep Nomdedeu, Ana Aventin, Montserrat Hoyos, Salut Brunet, Jordi Sierra
Journal: Blood (2011)
Left ventricular diastolic pressure-volume and stress-strain relationship in children.
Authors: Kaoru Yoshii, Hatsuo Iwao, Shoshi Fukuda, Yasuhiro MlZOGUCHI, Hiroshi Sunagawa, Sunao Honda
Journal: Circulation (1985)

Diastolic pressure and volume (P-V) curves were approximately exponential and fitted the equation, dP/dV = aP + b, where a was left ventricular volume elastic constant. Stress and strain (sigma-epsilon) curves were expressed by the equation, d sigma/d epsilon = k sigma + c, where k was wall stiffness constant. These exponential curves have been fitted over the whole diastole, but theoretically, the mid-diastole should reflect diastolic elastic properties best. In the present study, therefore, special attention was paid to the mid-diastole in each patient, and both P-V and sigma-epsilon relationships were analyzed by fitting the data to the above mentioned curves during this period of time. This analysis was made in two separate groups of patients. One was the control group consisting of 2 patients with normal hearts, 2 patients with mild pulmonary stenosis, and 25 patients with post mucocutaneous lymph node syndrome. The other group consisted of patients with postoperative congenital heart disease, that is, 8 patients with atrial septal defect and 5 patients with tetralogy of Fallot. The elastic constant (a) could not be compared if the size of the hearts differed. The results of the present study, however, demonstrated that the size of the heart was closely related to the constant, a. In the control group, the constant (a) was exponentially related to the size of the heart, and expressed as follows: a = 0.30e-0.037EDV + 0.045 (r = 0.94, p less than 0.01) In contrast, the wall stiffness constant (k) was not related to the size of the heart. After surgical repair of congenital heart disease, the stiffness constant in the left ventricle was normal in patients with postoperative atrial septal defect, while it was significantly increased in patients with postoperative tetralogy of Fallot.
Improved Killing of AML Blasts By Dual-Targeting of CD123 and CD33 Via Unitarg a Novel Antibody-Based Modular T Cell Retargeting System
Authors: Claudia Arndt, Anja Feldmann, Stefanie Koristka, Marc Cartellieri, Malte von Bonin, Armin Ehninger, Martin Bornhäuser, Gerhard Ehninger, Michael P Bachmann
Journal: Blood (2015)
Errors in <i>ICD-9</i> Codes and Percentages Reported in Tables
Authors: Luke K. Kim, Dmitriy N. Feldman
Journal: JAMA Cardiology (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Cardiology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Cardiology journal
Genetic Polymorphisms of Gluthatione-S-Transferases in Two Different Populations of Fanconi Anaemia Patients.
Authors: Juliana F. Fernandes, Vanderson Rocha, Raphael Porcher, Marco Bittencourt, Moema N. Santos, Yulia Skvortsova, Carmen Bonfim, Marli Tavela, Gerard Socie, Eliane Gluckman, Ricardo Pasquini, Marco Antonio Zago
Journal: Blood (2007)
P2.02-002 Association between VEGF Gene Functional Polymorphisms and Clinical and Pathological Characteristics of Non-Small Cell Lung Cancer
Authors: Anna Shchayuk, Evelina Krupnova, Michael Shapetska, Alena Mikhalenka, Natalia Chebotaryova, Svetlana Pissarchik
Journal: Journal of Thoracic Oncology (2017)
MA16.03 Global RET Registry (GLORY): Activity of RET-Directed Targeted Therapies in RET-Rearranged Lung Cancers
Authors: Oliver Gautschi, Julie Milia-Baron, Thomas Filleron, Jürgen Wolf, David Carbone, Dwight Owen, D. Ross Camidge, Vighesh Narayanan, Robert Doebele, Benjamin Besse, Jordi Remon, Pasi Jänne, Mark Awad, Nir Peled, Chul-Cho Byoung, Daniel Karp, Michael Van Den Heuvel, Heather Wakelee, Joel Neal, Tony Mok, James Chih-Hsin Yang, Sai-Hong Ou, Georg Pall, Patrizia Froesch, Gérard Zalcman, David R. Gandara, Jonathan Riess, Vamsidhar Velcheti, Kristin Zeidler, Joachim Diebold, Martin Früh, Sebastian Michels, Isabelle Monnet, Sanjay Popat, Rafael Rosell, Niki Karachaliou, Sacha Rothschild, Jin-Yuan Shih, Arne Warth, Thomas Muley, Florian Cabillic, Julien Mazieres, Alexander Drilon
Journal: Journal of Thoracic Oncology (2017)
The clinical observation of G-CSF used in supplementary chemotherapy of cancer patients
Authors: Z. Zhao
Journal: Journal of Clinical Oncology (2004)

2614 Background: To evaluate the effectiveness of different doses of G-CSF(granulocyte-colony stimulating factor) used to improve the condition of leukopenia after routine chemotherapy in cancer patients. Methods: 50 cancer patients (34 male, 16 female) who suffered stage III-IV cancer got leukopenia were treated with different doses of Granocyte (rh G-CSF manufactured by Chugai Pharmaceutical CO., LTD) after combined chemotherapy. The patients'average age is 56(48∼60) years old. They were randomized into two groups. During the stage of leukopenia,Group A with 25 patients were injected with Granocyte 100ug Bid subcutaneously after each cycle of chemotherapy for 7 to 14 days. Group B with 25 patients were injected with Granocyte150ug Bid subcutaneously for 7 to 14 days. The routine peripheral blood examinations were observed. Results: It took 7 to 10 days to treat leukopenia in Group A and took 5 to 7 days in Group B. The race of leucocyte recovery in group B is quicker than in group A. It has significantly statistical difference between two groups. Leucocyte count does not descent again after ascending and without infection. Conclusions: Granocyte(the only glycosylated rh G-CSF) is able to reduce the recovery time of functional bone marrow, decrease the time of leukopenia and prevent from infection. However, it cannot ameliorate the range of leukopenia. The recovery race of leukopenia has relationship with the dose of G-CSF. No significant financial relationships to disclose.
BRCA mutation carriers: Risk factors for psychosocial and physiologic disruption.
Authors: L. B. Wenzel, K. Osann, J. Gross, R. Kurz, E. L. Nelson, B. Y. Karlan
Journal: Journal of Clinical Oncology (2011)

9139 Background: BRCA mutation carriers live with unique psychosocial and health-specific stressors. The purpose of this study is to further identify variables which may contribute to stressors among BRCA mutation carriers and investigate correlates with stress-associated biomarkers. Methods: Women with maternally transmitted deleterious BRCA mutations were assigned to one of four focus groups, based on personal cancer history and mothers’ survival status. Focus group themes included life stress, health care decision-making, childbearing, and coping skills. One day in advance, a quality of life (QOL) survey and first morning salivary cortisol were obtained. Patient characteristics including personal diagnosis of cancer, prophylactic surgery, and mother’s vital status were evaluated in a multivariate linear model to identify factors associated with quality of life domains and perceived stress. Secondary assessment of serum cytokine levels was conducted. Results: Participants (N=32) were predominantly NonHispanic White. After controlling for age, women who lost their mothers due to cancer reported significantly lower QOL (p=0.002) and more perceived stress (p=0.015), intrusive thoughts related to cancer risk (p=0.026), and emotional distress (p=0.004) including depression (p=0.033) and anxiety (p=0.002) compared to women whose mothers were alive. Lower quality of life was also associated with higher bereavement scores (r=-0.78, p<0.001). In women whose mothers were deceased patient-reported outcomes were significantly correlated with cytokine profiles best summarized as being globally suppressed. Biological correlates were similarly associated with bereavement scores, with negative correlations for IL-17, IL-8, and GM-CSF (p<0.05). Personal cancer history and prophylactic surgery were not associated with quality of life after adjusting for age and mother’s status. Conclusions: BRCA mutation carriers whose mothers are deceased from cancer report lower quality of life, more stress and distress. This suggests that subpopulations of carriers are potentially at higher risk of chronic stress, which may be an important consideration for manifestations of illness in this cancer-vulnerable population.
OA22.06 Refinement of the Prognostic miR-Score for Use in Diagnostic Specimens from Chemo-Naïve Malignant Pleural Mesothelioma Patients
Authors: Michaela Kirschner, Bart Vrugt, Martina Friess, Mayura Meerang, Peter Wild, Nico Van Zandwijk, Glen Reid, Walter Weder, Isabelle Opitz
Journal: Journal of Thoracic Oncology (2017)
P122 Local sources rather than interactions with oxidising co-pollutant gases determine the geographical and seasonal variation in particulate matter oxidative potential
Authors: N Camina, DC Green, FJ Kelly, IS Mudway
Journal: Thorax (2016)

<h3>Background</h3> Reactions of ambient particulate matter (PM) with atmospheric radicals and oxidising gases such as nitrogen dioxide (NO<sub>2</sub>) and ozone (O<sub>3</sub>) may alter their toxicity – often referred to as particle ageing. As concentrations of O<sub>3</sub> dominate in the warmer months, with NO<sub>2 </sub>episodes more common in the winter, we investigated whether seasonal differences in the PM oxidative potential (the capacity of inhaled PM to cause damaging oxidation reactions at the air-lung interface) could be attributed to their interaction with these gases. <h3>Methods</h3> Daily PM<sub>10</sub> and PM<sub>2.5</sub> filters from 4 sites in Southern England were obtained during summer (21<sup>st</sup> July – 23<sup>rd </sup>August) and winter (6<sup>th</sup> Jan–11<sup>th</sup> Feb) campaigns in 2012: two sites in London, roadside (Marylebone Road) and urban background (North Kensington) locations, plus two rural sites to the West (Harwell) and East (Detling) of the city. Ascorbate and glutathione-dependent oxidative potential (OP<sup>AA</sup> and OP<sup>GSH</sup>, expressed per unit mass of PM) were then determined following incubation in a synthetic respiratory tract lining fluid (4 hours at 37<sup>o</sup>C, pH 7.0) using a novel on filter methodology. <h3>Results</h3> In terms of the OP<sup>AA</sup> metric only PM<sub>2.5 </sub>measured at the urban background location demonstrated a seasonal increase (p &lt; 0.05) during the summer, with equivalent seasonal OPs across the remaining 3 sites and no differences apparent in PM<sub>10</sub>. In contrast, PM<sub>10</sub> and PM<sub>2.5</sub> OP<sup>GSH</sup> was significantly (P &lt; 0.001) lower in the summer period at the urban background site. Summer increases in OP<sup>GSH</sup> were observed at the rural sites, with evidence that summer PM<sub>2.5</sub> OP<sup>GSH</sup> was increased at the roadside site. This heterogeneous pattern of seasonal contrasts could not be simplistically related to the differences in period, or daily NO<sub>2</sub> or O<sub>3</sub> concentrations. <h3>Conclusions</h3> No consistent seasonal pattern in PM<sub>10</sub> or PM<sub>2.5</sub> OP was observed across the four sites and the associations between the measured particulate OPs with O<sub>3</sub> and NO<sub>2</sub> at these locations did not fit with the particle ageing hypothesis. Rather high OP days were often found to be associated with wind speed and direction, suggesting that the differences were driven by a combination of long and short range sources.
Toward Prediction of Thrombosis in Adolescent Girls On Estrogen Containing Contraceptives: Global Coagulation Profiles and Estrogen Gene Polymorphisms.
Authors: Ayesha N. Zia, Michael U Callaghan, Anju Sawni, Alcesa Backos, Latha Rao, Meera B. Chitlur, Jeanne M. Lusher, Madhvi Rajpurkar
Journal: Blood (2012)
P2.01-041 Integrated Proteo-Genomics Analyses Reveal Extensive Tumor Heterogeneity and Novel Somatic Variants in Lung Adenocarcinoma
Authors: Romi Biswas, Shaojian Gao, Contance Cultraro, Xu Zhang, Tapan Maity, Corey Carter, Anish Thomas, Arun Rajan, Ken-Ichi Hanada, Young Song, Zied Abdullaev, Paul Meltzer, James Yang, Svetlana Pack, Giuseppe Giaccone, Javed Khan, Udayan Guha
Journal: Journal of Thoracic Oncology (2017)
Ex Vivo Expansion of Human Hematopoietic Stem Cells by a Small-Molecule Agonist of c-MPL.
Authors: Taito Nishino, Katsuaki Miyaji, Norihisa Ishiwata, Kazutaka Arai, Makiko Yui, Yasuyuki Asai, Hiromitsu Nakauchi, Atsushi Iwama
Journal: Blood (2009)