Hypervitaminosis D Associated With Tanning Bed Use: A Case Report
Authors: Michaël R. Laurent, Evelien Gielen, Steven Pauwels, Dirk Vanderschueren, Roger Bouillon
Journal: Annals of Internal Medicine (2017)

Letters17 January 2017Hypervitaminosis D Associated With Tanning Bed Use: A Case ReportMichaël R. Laurent, MD, Evelien Gielen, MD, PhD, Steven Pauwels, PharmD, Dirk Vanderschueren, MD, PhD, and Roger Bouillon, MD, PhDMichaël R. Laurent, MDFrom University Hospitals Leuven and KU Leuven, Leuven, Belgium., Evelien Gielen, MD, PhDFrom University Hospitals Leuven and KU Leuven, Leuven, Belgium., Steven Pauwels, PharmDFrom University Hospitals Leuven and KU Leuven, Leuven, Belgium., Dirk Vanderschueren, MD, PhDFrom University Hospitals Leuven and KU Leuven, Leuven, Belgium., and Roger Bouillon, MD, PhDFrom University Hospitals Leuven and KU Leuven, Leuven, Belgium.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/L16-0138 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Background: The amount of ultraviolet B (UV-B) radiation absorbed by the skin determines serum 25-hydroxyvitamin D (25-[OH]D) concentrations. Conventional teaching holds that UV-B radiation from sunlight or tanning beds cannot induce vitamin D toxicity (1).Objective: To support recent information that contradicts this conventional teaching (2).Case Report: A 48-year-old postmenopausal woman developed a spontaneous pubic and bilateral sacrum fracture in December 2012. Nine months earlier, she had undergone surgical fusion of the second lumbar vertebra to the sacrum for degenerative scoliosis with secondary neurogenic claudication. Blood tests found increased levels of total alkaline phosphatase and 25-(OH)D with normal levels ...References1. Bouillon R, Van Schoor NM, Gielen E, Boonen S, Mathieu C, Vanderschueren D, et al. Optimal vitamin D status: a critical analysis on the basis of evidence-based medicine. J Clin Endocrinol Metab. 2013;98:E1283-304. [PMID: 23922354] doi:10.1210/jc.2013-1195 CrossrefMedlineGoogle Scholar2. Singh P, Trivedi N. Tanning beds and hypervitaminosis D: a case report [Letter]. Ann Intern Med. 2014;160:810-1. [PMID: 24887628]. doi:10.7326/L14-5011-8 LinkGoogle Scholar3. Swanson CM, Nielson CM, Shrestha S, Lee CG, Barrett-Connor E, Jans I, et al; Osteoporotic Fractures in Men (MrOS) Study Research Group. Higher 25(OH)D2 is associated with lower 25(OH)D3 and 1,25(OH)2D3. J Clin Endocrinol Metab. 2014;99:2736-44. [PMID: 24828488] doi:10.1210/jc.2014-1069 CrossrefMedlineGoogle Scholar4. Bouillon R, Van Assche FA, Van Baelen H, Heyns W, De Moor P. Influence of the vitamin D-binding protein on the serum concentration of 1,25-dihydroxyvitamin D3 Significance of the free 1,25-dihydroxyvitamin D3 concentration. J Clin Invest. 1981;67:589-96. [PMID: 6894152] CrossrefMedlineGoogle Scholar5. Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 2016;96:365-408. [PMID: 26681795] doi:10.1152/physrev.00014.2015 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From University Hospitals Leuven and KU Leuven, Leuven, Belgium.Disclosures: Disclosures can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L16-0138. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVitamin D and Bone Health: Basic and Clinical AspectsBone: best papers of the year 2017Vitamin D insufficiency: Definition, diagnosis and managementGenetic and Racial Differences in the Vitamin D Endocrine SystemComparative analysis of nutritional guidelines for vitamin D 17 January 2017Volume 166, Issue 2Page: 155-156KeywordsAttentionBoneCalciumDisclosurePhosphatasesSurgeryToxicityUrineVitamin DVitamin D deficiency ePublished: 17 January 2017 Issue Published: 17 January 2017 Copyright & PermissionsCopyright © 2017 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...