tbuckley/cabot-search huggingface dataset:
Expression in non-small-cell lung cancer (NSCLC) of vascular endothelium growth factor (VEGF)-A, VEGF receptor (VEGFR)-1, VEGF-C and VEGF-R3: Correlation with histology and lymph node metastases
Authors: P. Saintigny, O. Sainte-Catherine, M. Kambouchner, A. Doueik, J.-L. Breau, J.-F. Morère, J.-F. Bernaudin, M. Kraemer
Journal: Journal of Clinical Oncology (2005)

9698 Background: Resected NSCLC has a high risk of relapse and lymph nodes (LN) metastasis is still their major prognostic factor. This study was designed to evaluate in NSCLC, the coexpression of VEGF-A and its receptor VEGF-R1, involved in angiogenesis, and VEGF-C and its receptor VEGF-R3, involved in lymphangiogenesis, and their correlation with histology and LN metastasis. Methods: 48 consecutively resected NSCLC without preoperative chemotherapy were studied: 25 adenocarcinomas (AC), 18 squamous cell carcinomas (SCC) and 5 large cell carcinomas (LCC): 50% were pN0 (AC n=14, SCC n=7, LCC n=3) and 50% pN1–2 (AC n=11, SCC n=11, LCC n=2). Expression of VEGF-A, VEGF-R1, VEGF-C and VEGF-R3 was evaluated by immunohistochemistry on tissue sections. Labelling intensity (score 0 to 3) and percentage of expressing cells were double-blindly evaluated: a tumor was defined as positive when a labelling score of 1 in at least 50% cells, or score 2 or 3 in at least 30% cells was observed. Results: 10 tumors (20%) (AC n:7, SCC n:1, LCC n:2) expressed VEGFA; 18 (37.5%) VEGF-R1 (AC n:10, SCC n:7, LCC n:1), 5 (10%) coexpressed VEGF-A/VEGF-R1 (AC n:4, SCC n:1). Thirty-two (65%) expressed VEGF-C (AC n:14, SCC n:16, LCC n:2), 18 (37.5%) expressed VEGF-R3 (AC n:4, SCC n:13, LCC n:1) and 16 coexpressed VEGF-C/VEGF-R3 (AC n:2, SCC n:13, LCC n:1). A VEGF-A expression was associated with AC histology while VEGF-R3 was associated with SCC histology (p=0.046). VEGF-A was expressed in 7 pN0 and 3 pN1–2 tumors; VEGF-R1 in 12 pN0 and 4 pN1–2 tumors; VEGF-C in 13 pN0 and 15 pN1–2 tumors, and VEGF-R3 in 5 pN0 and 12 pN1–2 (p=0.039). Conclusions: A potential role of autocrine and/or paracrine VEGF pathways can be hypothesized in NSCLC particularly for the VEGF-C/VEGF-R3 loop as VEGF-R3 expression is significantly associated with LN metastasis. The risk of relapse associated to pN0 tumors expressing VEGF-A, VEGF-R1, VEGF-C and VEGF-R3 has to be appraised in a larger series of patients. No significant financial relationships to disclose.
Final results of a phase I study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor receptors (VEGFR), in combination with carboplatin (C) + paclitaxel (T) in patients with advanced non-small cell lung cancer (NSCLC): A study of the National Cancer Institute of Canada Clinical Trials Group (NCIC CTG)
Authors: S. A. Laurie, A. Arnold, I. Gauthier, E. Chen, G. Goss, P. Ellis, F. A. Shepherd, S. Matthews, J. Robertson, L. Seymour
Journal: Journal of Clinical Oncology (2006)

3054 Background: AZD2171 is a potent oral inhibitor of the tyrosine kinase activity of all VEGFR subtypes. This study was undertaken to determine the recommended phase II dose of AZD2171 in conjunction with standard doses of C and T, and to assess the tolerability, safety, PK profile and anti-tumor activity of this combination. Methods: Patients with stage IIIB / IV NSCLC (any histology); PS 0–2; no prior chemotherapy for metastatic disease and no significant hemoptysis / bleeding, were eligible. Treated, clinically stable brain metastases were permitted. C - AUC 6, and T - 200 mg/m 2 over 3 hours, q3weekly. AZD2171 commenced day 2 cycle 1 at a starting dose of 30 mg po daily. PK profile of all was drugs performed during cycles 1 and 2. Response was assessed by RECIST every second cycle. Results: 20 patients were enrolled: AZD2171 30 mg (9 pts) and 45 mg (11 pts). Median age 58; 19 PS 0 / 1; 8 females. At 30 mg, one confirmed DLT was observed (grade 3 ALT); hypertension ≥ grade 2 was seen in 6 pts, prompting the institution of a standardized algorithm for management of this predictable toxicity. Of the first 3 pts enrolled to the 45 mg dose level, one DLT was observed (grade 3 febrile neutropenia with grade 3 mucositis); no further DLT was observed in the expanded cohort. Other common toxicities: fatigue, anorexia, mucositis and diarrhea. Hematologic toxicity was not greater than that expected with CT alone. No hemoptysis was seen. To date, 15 pts are evaluable for response: 6 PR, 8 SD and 1 PD. Many SD pts had evidence of tumor shrinkage, including central cavitation. Conclusions: Toxicities of this combination appear manageable and predictable. Full single-agent dose of AZD2171 may be administered with standard C+T. Hypertension, a typical toxicity of inhibitors of VEGF signaling, was observed but manageable. Encouraging anti-tumor activity of the combination has been observed. NCIC CTG BR.24, a phase II/III trial of C+T with AZD2171/placebo is underway. [Table: see text]
Human Herpesvirus 7 Induces CD4+ T-Cell Death by Two Distinct Mechanisms: Necrotic Lysis in Productively Infected Cells and Apoptosis in Uninfected or Nonproductively Infected Cells
Authors: Paola Secchiero, Louis Flamand, Davide Gibellini, Elisabetta Falcieri, Iole Robuffo, Silvano Capitani, Robert C. Gallo, Giorgio Zauli
Journal: Blood (1997)
Proliferative and Antigenic Modifications in Human Epithelial Cells in Chronic Atrophic Gastritis&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: M Lipkin, P Correa, Y B Mikol, P J Higgins, C Cuello, G Zarama, E Fontham, D Zavala
Journal: JNCI Journal of the National Cancer Institute (1985)

For the study of both proliferative and antigenic changes in epithelial cells in a disease predisposing to gastric cancer, endoscopic biopsy specimens were analyzed following removal from individuals with chronic atrophic gastritis (CAG); comparisons were made with specimens from normal gastric mucosa. All subjects were from Nariño, Colombia, the population of which has a high age-adjusted incidence of gastric cancer (150/100,000 population) occurring mainly in gastric antrum. After pulse incubation of biopsy specimens with tritiated thymidine ([3H]dThd), microautoradiographic distributions of [3H]dThd-labeled cells in the epithelial lining of gastric pits were correlated with expression of serologically defined gamma-fetal antigen (FA) as a second marker. Measurements were done both in gastric corpus and in antrum for entire gastric pits and over multiple gastric pit compartments. Total numbers of cells per gastric pit column did not differ between the normal and the CAG specimens either in corpus or in antrum; however, both in corpus and in antrum mean numbers of [3H]dThd-labeled cells per gastric pit column and labeling index were almost twice as large for the CAG population (P less than .006). Labeling index differences also were significant over most gastric pit compartments (P less than .02). In antrum gamma-FA-positive lesions had an expanded proliferative compartment with labeling indices significantly greater than those of antigen-negative lesions (P less than .02). This correlation did not extend to biopsy specimens obtained from corpus of stomach where the frequency of carcinoma is low. Findings indicate a hyperproliferative state in CAG compared to the proliferative state in normal gastric mucosa and, in gastric antrum, a further correlation with expression of gamma-FA in hyperproliferating cells. The two markers can be used to aid definition of the gastric mucosa in a disease associated with the development of gastric cancer and in prophylactic dietary intervention programs.
Case 26-1971
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Morton N. Swartz, Benjamin Castleman
Journal: New England Journal of Medicine (1971)

Presentation of CaseA 20-year-old man was admitted to the hospital because of fever.The patient had been a sickly child, with a severe pectus excavatum deformity. At the age of four years he was placed in a foster home because of the separation of his parents. Three years before admission he ran away to California, where he became addicted to amphetamine and to heroin. He had taken as many as five doses of heroin daily by vein when circumstances permitted. Although he regularly used his own needle, which he cleansed in hydrogen peroxide, he believed that he had had . . .
Two Patients with Cystic Fibrosis, Nonsense Mutations in Each Cystic Fibrosis Gene, and Mild Pulmonary Disease
Authors: Garry R. Cutting, Laura M. Kasch, Beryl J. Rosenstein, Lap-Chee Tsui, Haig H. Kazazian, Stylianos E. Antonarakis
Journal: New England Journal of Medicine (1990)

CYSTIC fibrosis is the most common lethal inherited disorder in the white population. It is manifested by viscous secretions in the lungs and pancreas and abnormal electrolyte composition of sweat.1 Epithelial cells from patients with cystic fibrosis have abnormal conductance of chloride ions across apical membranes due to defective regulation of a particular chloride channel.2 3 4 Inadequate secretion of chloride is believed to cause the insufficient hydration of mucus in the airways and pancreatic ducts.1 The cystic fibrosis gene has recently been identified, and it is predicted to encode a 1480-amino-acid protein termed the cystic fibrosis transmembrane conductance regulator (CFTR).5 , 6 The . . .
A curriculum for education in geriatric psychiatry
Authors: R S Marin, J R Foster, C V Ford, B V Reifler, B Reisberg, C B Robinowitz, W H Sledge, J Spar, P J Tighe
Journal: American Journal of Psychiatry (1988)

The authors present recommendations for educating medical students and psychiatric residents in geropsychiatry. They are primarily concerned with the objectives and methods rather than the content of training. Proposals are structured in terms of training objectives and educational settings in which such training takes place. The proposals are intended to be specific enough to be truly useful and at the same time sufficiently generalizable to adapt to geropsychiatric training in a variety of institutions. Priority is given to integrating knowledge of normal and abnormal aging with the clinical skills and empathy necessary to approach patients with competence and understanding.
Treatment of Severe Colchicine Overdose with Colchicine-Specific Fab Fragments
Authors: Frédéric J. Baud, Alain Sabouraud, Eric Vicaut, Pierre Taboulet, Jean Lang, Chantal Bismuth, Jean Marc Rouzioux, Jean-Michel Scherrmann
Journal: New England Journal of Medicine (1995)

T HE use of colchicine is limited by its toxicity, 1 and colchicine overdose is associated with a high mortality rate.Patients with early hemodynamic collapse due to colchicine overdose have particularly poor prognoses, 2,3 and there has been no effective treatment for this complication of severe colchicine intoxication. 4olchicine binds reversibly to tubulin, 5 and colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro. 6,7][10][11] These findings suggested that colchicine-specific Fab fragments could be of value in the treatment of life-threatening colchicine poisoning, such as is true of digoxin-specific Fab fragments in digitalis poisoning. 12e here describe the successful use of this treatment in a woman who had ingested 60 mg of colchicine in a suicide attempt.
Case 4-1986
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Dennis L. Kasper, Robert E. Scully
Journal: New England Journal of Medicine (1986)

Presentation of CaseAn 18-year-old woman was admitted to the hospital because of nausea, vomiting, arthralgia, and hypotension.She was well until eight weeks earlier, when a sore throat developed at about the time of her menses, accompanied by mild arthralgia and myalgia. A throat culture yielded beta-hemolytic streptococci. Penicillin was administered but was discontinued by the patient after one week because of gastrointestinal symptoms. Four weeks before admission, during her next menstrual period, she again experienced a sore throat, arthralgia, and myalgia, as well as nausea, vomiting, malaise, diarrhea, and a rash. Erythromycin was administered, with resolution of the . . .
Wealth, health expenditure, and cancer: A national perspective.
Authors: Jad Chahoud, Alyssa G. Rieber, Adele Semaan
Journal: Journal of Clinical Oncology (2015)

6546 Background: The healthcare system in the United States (US) is characterized by high expenditures with penultimate health outcomes. Socioeconomic status is a strong determinant of general population health. Our study evaluates the associations between (1) wealth and cancer outcomes, and (2) health expenditure and cancer outcomes at the State level. Methods: We used publicly available data from the Bureau of Economic Analysis, the Centers for Medicare and Medicaid Services and the United States Cancer Statistics. We employed GDP per capita and Health expenditure per capita as indicators for wealth and health expenditure respectively. As for cancer outcomes, we used incidence and mortality rates as well as mortality/incidence (M/I) ratios. We constructed scatter plots to illustrate these associations and used the Spearman's rank correlation coefficient to determine their strength, directionality and significance. Results: GDP per capita was significantly correlated with lower M/I ratios for all cancers (rho = -0.4406; p = 0.0017), breast cancer (rho = -0.3605; p = 0.0118) and colorectal cancer (CRC) (rho = -0.3612; p = 0.0117). As for health expenditure per capita, a preliminary descriptive analysis highlighted a rift between the Northeastern and the Southern States. This wide gap in health expenditure translated into worse all-cancer and breast cancer outcomes in Southern states. Further analysis showed that higher health expenditure was significantly correlated with decreased breast cancer M/I ratio (rho = -0.4237; p = 0.0027). However, CRC outcomes were not significantly affected by high health expenditure (rho = -0.1634; p = 0.2670), neither were all-cancer outcomes (rho = -0.2458; p = 0.0922). Conclusions: Cancer outcomes are strongly correlated with wealth as both breast cancer and CRC had significantly better outcomes in states with higher GDP per capita. However, only breast cancer outcomes were significantly correlated with higher health expenditure. CRC outcomes were not associated with higher health expenditure. This highlights a need for future research assessing the optimization of resource allocation in the States' efforts against CRC.
214P: Correlation of thymoma with myasthenia gravis in ten years experience of their surgical treatment
Authors: F. Caushi, D. Xhemalaj, A. Kuqo, I. Skenduli, A. Hatibi, H. Hafizi, E. Bejtja, R. Kortoci, F. Kokiqi, E. Shima
Journal: Journal of Thoracic Oncology (2016)
Evaluation Of Seasonality In The Incidence Of Promyelocytic Leukemia In Brazil
Authors: Karine Sampaio Nunes Barroso, Irene Lorand-Metze, Katia B. Pagnano, Eduardo M. Rego, Raul A Melo, Rosane Bittencourt, Ricardo Pasquini, Evandro Fagundes, Rafael Jacomo, Carlos S Chiattone, Maria de Lourdes L. F. Chauffaille, Konradin Metze
Journal: Blood (2013)
S116 GDF-15, the miR-542 cluster and miR-422a are associated with muscle wasting in Intensive Care Unit Acquired Paresis
Authors: RG Paul, MI Polkey, PR Kemp, MJD Griffiths
Journal: Thorax (2015)

<h3>Introduction and aims</h3> Intensive care unit acquired paresis (ICUAP) is a common complication of critical illness, associated with significant morbidity and mortality in patients admitted to the ICU. To date, there has been little success in the identification of patients at risk of acute muscle wasting or potential targets for therapeutic intervention. GDF-15, a TGF-B family member, has been shown to be a potential driver of acute muscle wasting in ICUAP (Crit Care Med 2013;41:982). From previous analyses in ICUAP and other wasting conditions, we hypothesised that pre-surgery expression of microRNAs from the miR-542 family would be higher in patients who would lose significant muscle bulk following surgery, whereas expression of miR-422a would be lower. <h3>Methods</h3> A prospective observational study of 40 patients undergoing high-risk cardiothoracic surgery with cardiopulmonary bypass was conducted. Patients underwent pre- and post-operative paired rectus femoris biopsies and blood sampling. Muscle wasting was assessed by ultrasound pre-operatively and at day 7 post surgery. Plasma GDF-15 protein was quantified by ELISA and mRNA and microRNA expression in muscle specimens by RT-PCR. <h3>Main results</h3> 52% (21 of 40) patients developed muscle atrophy. Plasma GDF-15 concentration was significantly raised at all sampling time points in patients with significant muscle wasting (wasters) compared to those that did not (non-wasters). miR-542–3p (median 1.9-fold, p = 0.0029), miR-542–5p (median 4.5-fold, p = 0.0346) and miR-424 (median 4.2-fold, p = 0.0040) were higher in pre-operative muscle specimens of wasters compared to non-wasters, whilst miR-422a was lower (median 1.2-fold, p = 0.0176). Expression of these miRNAs significantly correlated with change in rectus femoris cross-sectional area over time (see Figure 1). <h3>Discussion</h3> Pre-operative expression in muscle of these miRNAs correlates significantly with reductions in muscle bulk after major surgery and cardiopulmonary bypass suggesting that the pre-existing status of the muscle is important in the susceptibility to muscle wasting. Furthermore, as both miR-542–3p/-5p and miR-422a are predicted to regulate p53 activity in opposite directions, these data imply that the p53 stress pathway contributes to this susceptibility. This study identifies these microRNAs as potential therapeutic targets in ICUAP.
Choosing Wisely Recommendations Using Administrative Claims Data
Authors: Geoffrey B. Crawford, Jeffrey Clyman, David S. Chiou
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Diphenylhydantoin and Selected Congenital Malformations
Authors: Richard R. Monson, Lynn Rosenberg, Stuart C. Hartz, Samuel Shapiro, Olli P. Heinonen, Dennis Slone
Journal: New England Journal of Medicine (1973)

In a cohort of 50,897 pregnancies, frequencies of malformations, selected on the basis of reports in the literature, were compared between four groups of children born to epileptic mothers and those born to nonepileptic mothers. The highest malformation rate (61 per 1000) was observed in 98 children exposed during the early months of pregnancy to daily diphenylhydantoin (phenytoin) use. The rate was lowest in 50,591 children born to nonepileptic women (25 per 1000). It was intermediate in children of epileptic mothers exposed before delivery to sporadic or late use of diphenylhydantoin, and in children of such mothers who were not exposed to the drug. Among epileptic women with varying or no exposure to diphenylhydantoin, the malformation rates did not differ significantly. The difference in the malformation rates between children exposed regularly to diphenylhydantoin during early gestation and children born to nonepileptic mothers could reflect the teratogenic effect of the drug, of epilepsy itself or of both factors. (N Engl J Med 289:1049–1052, 1973)
l-asparaginase-based regimens followed by allogeneic hematopoietic stem cell transplantation improve outcomes in aggressive natural killer cell leukemia
Authors: Ki Sun Jung, Su-Hee Cho, Seok Jin Kim, Young Hyeh Ko, Eun-Suk Kang, Won Seog Kim
Journal: Journal of Hematology & Oncology (2016)

Aggressive nature killer cell leukemia (ANKL) is a mature NK-T cell lymphoma with worse prognosis, but optimal treatment is unclear. Therefore, we analyzed the efficacy of l-asparaginase-based regimens for ANKL patients. Twenty-one patients who received dexamethasone, methotrexate, ifosfamide, l-asparaginase, and etoposide (SMILE) or etoposide, ifosfamide, dexamethasone, and l-asparaginase (VIDL) chemotherapy at Samsung Medical Center were selected. The overall response rate for all patients was 33 % (7/21); 38 % (5/13) in SMILE and 40 % (2/5) in VIDL, respectively. The median progression-free survival was 3.9 months (95 % CI 0.0–8.1 months) and median overall survival was 7.0 months (95 % CI 2.3–11.7 months). Treatment response (P = 0.001), hematopoietic stem cell transplantation (HSCT) (P = 0.007) and negative conversion of Epstein-Barr virus (EBV) DNA titer after treatment (P = 0.004) were significantly associated with survival. Thus, l-asparaginase-based regimens followed by allogeneic HSCT seem to improve the outcome for ANKL patients.
Abstract 14947: Cardiac-specific Expression of iNOS using an AAV9 Vector in Combination with the Cardiac Troponin-T Promoter Inhibits LV Remodeling after Reperfused Myocardial Infarction
Authors: Prasad R Konkalmatt, Ronald J Beyers, Yaqin Xu, Brent A French
Journal: Circulation (2012)

Objectives: Expression of inducible nitric oxide synthase (iNOS) is dramatically increased in the heart after myocardial infarction (MI). Previous reports on the role of iNOS in post-MI left ventri...
A Randomized Study of the Effects of Aerobic Exercise by Lactating Women on Breast-Milk Volume and Composition
Authors: Kathryn G. Dewey, Cheryl A. Lovelady, Laurie A. Nommsen-Rivers, Megan A. McCrory, Bo Lonnerdal
Journal: New England Journal of Medicine (1994)

The potential risks and benefits of regular exercise during lactation have not been adequately evaluated. We investigated whether regular aerobic exercise had any effects on the volume or composition of breast milk.
Ceftazidime-avibactam or best available therapy in patients with ceftazidime-resistant Enterobacteriaceae and Pseudomonas aeruginosa complicated urinary tract infections or complicated intra-abdominal infections (REPRISE): a randomised, pathogen-directed, phase 3 study
Authors: Yehuda Carmeli, Jon Armstrong, Peter J Laud, Paul Newell, Greg Stone, Angela Wardman, Leanne B Gasink
Journal: The Lancet Infectious Diseases (2016)
Zinc Therapy of Acrodermatitis Enteropathica
Authors: Kenneth H. Neldner, K. Michael Hambidge
Journal: New England Journal of Medicine (1975)

The therapeutic effect of orally administered zinc was evaluated in an adult woman with acrodermatitis enteropathica. When she was off therapy and in clinical relapse the plasma zinc concentration (10 mug per 100 ml), serum alkaline phosphatase (3 1U per liter) and urine zinc excretion rate (39 mug per 24 hours) were extremely low. Di-iodohydroxyquin therapy was accompanied by a modest increase in plasma zinc concentrations. Oral zinc sulfate (220 mg three times a day or 50 mg twice a day) resulted in rapid and complete clinical remission, and in a return of plasma zinc, serum alkaline phosphatase and urinary zinc excretion to normal. These data are compatible with a severe zinc deficiency state and indicate that the inherited defect in this disease is either in or closely related to zinc metabolism. The beneficial effects of zinc therapy in this patient provide further confirmation of the efficacy of oral zinc in the treatment of acrodermatitis enteropathica.