tbuckley/cabot-search huggingface dataset:
Aggravation of Subclinical Diabetes Insipidus during Pregnancy
Authors: Y Iwasaki, Y Oiso, K Kondo, S Takagi, K Takatsuki, H Hasegawa, K Ishikawa, Y Fujimura, S Kazeto, A Tomita
Journal: New England Journal of Medicine (1991)

Transient polyuria and polydip-sia during pregnancy are rare, and their cause is not en-tirely clear. Possible explanations include the exacerba-tion of preexisting abnormalities in the secretion or action of vasopressin and abnormally large increases in plasma vasopressinase activity.
Normalization of the Blunted Ventilatory Response to Acute Hypoxia in Congenital Cyanotic Heart Disease
Authors: Marta I. Blesa, Sukhamay Lahiri, William J. Rashkind, Alfred P. Fishman
Journal: New England Journal of Medicine (1977)

Patients with congenital cyanotic heart disease have a blunted ventilatory response to hypoxia, but the permanence of the blunting is disputed. To determine how early the blunted ventilatory response develops and whether it is reversible, we studied three groups of children and young adults: five (seven to 13 years of age) with acyanotic heart disease, eight (seven to 16) with cyanotic congenital heart disease (arterial oxygen saturation, 55 to 83 per cent), and 13 (seven to 17) whose cardiac defects were repaired (arterial oxygen saturation, 93 to 98 per cent). The ventilatory response to acute hypoxia was subnormal in the hypoxemic children in that their ventilation showed little increase when arterial oxygen saturation fell by 10 to 20 per cent, compared to a 150 to 300 per cent increase in the control subjects. This characteristic even appeared in a seven-year-old patient, indicating that the disorder occurs in early life. The appearance of blunted ventilatory response is delayed when hypoxia from birth is less severe. After operation, with return of the arterial hypoxemia to normal, the response was in the normal range. We conclude that the blunted response is reversible. (N Engl J Med 296:237–241, 1977)
Extraction of Soluble Antigens of Epstein-Barr Virus, &lt;italic&gt;Herpervirus saimiri&lt;/italic&gt;, and &lt;italic&gt; Herpesvirus ateles &lt;/italic&gt; With the Use of Glycine
Authors: D V Ablashi, J M Easton, G R Armstrong, Z Bengali
Journal: JNCI Journal of the National Cancer Institute (1979)

For extraction of soluble antigen from cells rnfected with Epstein-Barr virus, Herpesvirus saimiri, and H. ateles, 0.1 M glycine (pH 9.5) was used. This method yielded increased amounts of the antigen containing much less cell debris. Lymphoblastold cells infected with Epstein-Barr virus could maintain up to 50% viability after the extraction procedure. These cells could be used again after an appropriate interval in culture. The usefulness of this technique is dlscussed
Exposure to Road Traffic Noise and Behavioral Problems in 7-Year-Old Children: A Cohort Study
Authors: Dorrit Hjortebjerg, Anne Marie Nybo Andersen, Jeppe Schultz Christensen, Matthias Ketzel, Ole Raaschou-Nielsen, Jordi Sunyer, Jordi Julvez, Joan Forns, Mette Sørensen
Journal: Environmental Health Perspectives (2015)

Exposure to traffic noise has been associated with adverse effects on neuropsychological outcomes in children, but findings with regard to behavioral problems are inconsistent.
M32 Design and development of a new pMDI training aid
Authors: MJ Sanders, R Bruin, C Tran
Journal: Thorax (2015)

<h3>Introduction and objectives</h3> Despite differences in actuator resistance between pressurised metered dose inhalers (pMDIs), ‘inhale deeply and slowly’ remains universally recommended for drug delivery. Training aids to tutor inspiratory flow rate are vulnerable to resistance effects and can lead to patient error under a misconception of corrected technique. Actuator mouthpiece design can also limit availability of suitable training devices. Using the Flutiform low-resistance pMDI (Napp Laboratories Ltd), we describe here the development and testing of a suitable training aid based on the audible tone Flo-Tone trainer (Clement Clarke). <h3>Methods</h3> Flutiform 5 µg formoterol fumarate/125 µg fluticasone propionate (4.5/115 µg ex-actuator respectively) was assessed via the Next Generation Impactor (NGI) operated at 30 L/min, alone, and together with machined (Ma) or moulded (Mo) mouthpiece adaptors attached to the commercially available Flo-Tone (FTc), anti-static plastic Flo-Tone (FTas), or an abbreviated version (FTab). All least three replicates of each were completed. Drug recovery (µg) from the actuator, adaptor, Flo-Tone, induction port and NGI was determined. The key aerosol performance parameters Fine Particle Fraction (FPF,% &lt;5 µm) and Fine Particle Dose (FPD, µg &lt;5 µm) were determined. <h3>Results</h3> Formoterol and fluticasone drug delivery data trends were the same. Here we report the fluticasone data. Drug mass recovery (Figure 1) indicated that the moulded mouthpiece adaptor with abbreviated Flo-Tone (Mo-FTab) approximated most closely to Flutiform drug delivery without a training aid. All prototypes showed reduced throat (induction port) deposition. FPF% and FPD µg data for all prototypes, respectively, were: Flutiform alone, 44.8, 46.9; Ma1-FTc, 36.7, 37.3; Ma2-FTc, 33.1, 34.5; Mo-FTc, 36.0, 38.0; Mo-FTas, 34.4, 36.9; and Mo-FTab, 44.6, 46.4. <h3>Conclusions</h3> This process has shown that it is possible to tailor an existing audible training aid to a specific pMDI, enabling an audible training tone at an appropriate inspiratory flow rate without drug delivery compromise. We are currently extending this design-development research to create a standardised device suitable for a range of pMDIs in popular use and that vary in actuator resistance.
A New Longer-Acting LHRH Analog Depot: Preliminary Results of a Dutch Open Phase II Clinical Study on a 10.8 mg Zoladex 3-Monthly Depot
Authors: G A Dijkman, P Fernandez del Moral, J W Plasman, H C Pull, A P van der Meijden, F M Debruyne, F G Hutchinson, B J Furr
Journal: European Urology (1990)
Phase II study of AZD4547 in<i> FGFR</i> amplified tumours: Gastroesophageal cancer (GC) cohort pharmacodynamic and biomarker results.
Authors: Elizabeth Catherine Smyth, Nicholas C. Turner, Alex Pearson, Clare Peckitt, Ian Chau, David J. Watkins, Naureen Starling, Sheela Rao, Angela Gillbanks, Elaine Kilgour, Katherine Anne Sumpter, Neil R. Smith, Ros Cutts, Claire Rooney, Anne L. Thomas, Mazhar A. Ajaz, Sue Chua, Gina Brown, Sanjay Popat, David Cunningham
Journal: Journal of Clinical Oncology (2016)

154 Background: FGFR amplified tumors demonstrate oncogene addiction in vitro and in vivo. We examined the efficacy of AZD4547, an orally available inhibitor of FGFR 1, 2 &amp; 3, in FGFR1/2 amplified cancers, and herein present results from a gastroesophageal cancer (GC) cohort. Methods: Phase II Simon 2 stage design (3 independent cohorts) for previously treated patients (pts) with advanced FGFR1 (HER2 negative breast/NSCLC) or FGFR2 amplified tumors. FGFR1/2 amplification was centrally assessed using FISH. Pts received AZD4547 80mg twice daily. Primary endpoint is centrally confirmed response rate (RR), with the study concluding efficacy if ≥ 3/17 patients in a cohort had a confirmed response. PET-CT was performed at baseline, D14 and 8 wks, biopsy at baseline and D14 and optionally on progression. Biomarkers included FGFR copy number variation in tumor and plasma, NanoString gene expression, MIRAX digital FISH imaging and phospho-immunohistochemistry. Results: Of 288 pts with screening results, 9% (12/138) gastroesophageal (GC) pts had FGFR2 amplification with 5% (7/138) highly amplified (FGFR2 ratio &gt; 5.0). Confirmed RR was 33% (3/9) in FGFR2 amplified GC. Mean duration of response in responders was 5.7 months. All GC responders had a PET response on D14 PET. Common toxicities (all pts n = 18) included fatigue (72%), constipation (50%) mucositis, skin and eye changes (44% each). Phospho-immunohistochemistry on pre-treatment and D14 biopsies demonstrated an increase in S6 and decrease in p-ERK following treatment. Using digital droplet PCR (ddPCR) elevated FGFR2 copy number was detected in free plasma DNA of all responding GC pts, and no non-responding pt. NanoString and MIRAX imaging analysis revealed the presence of truncated C3 FGFR2 isoform and high level homogenous FGFR2 amplification in all GC responders respectively. Conclusions: AZD4547 demonstrated promising activity in FGFR2 amplified GC. On treatment biopsies demonstrate evidence of target inhibition. Clonal, high level amplification appears to be required for response to AZD4547. As all responding patients had FGFR2 copy number gain detected in plasma using ddPCR this technique will be developed as a screening tool. Clinical trial information: NCT01795768.
Allergy Testing of Multiple Patients Should No Longer Be Performed with a Common Syringe
Authors: Charles T. Lutz, C. Elliott Bell, H. James Wedner, Donald J. Krogstad
Journal: New England Journal of Medicine (1984)

Occasionally, medical practices are inadvertently found to pose the risk of serious harm to the patients they are designed to help. Often, these are established practices that have simply not been reexamined in the light of new knowledge, and they may be found in both medical centers and private offices. We believe that the use of single syringes with multiple needles for the intradermal skin testing of more than one patient is such a practice, and that patients who receive such injections are at risk of acquiring hepatitis B, acquired immunodeficiency syndrome (AIDS),1 and other diseases that may be transmitted . . .
WW domain containing E3 ubiquitin protein ligase 1 (WWP1) expression in breast cancer and its correlation with estrogen receptor (ER) and insulin-like growth factor receptor 1 (IGF-1R) status
Authors: J. S. Ross, E. Slodkowska, C. E. Sheehan, Z. Zhou, C. B. Sheehan, C. Chen
Journal: Journal of Clinical Oncology (2008)

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Relief of Pruritus and Decreases in Plasma Histamine Concentrations during Erythropoietin Therapy in Patients with Uremia
Authors: Sergio De Marchi, Emanuela Cecchin, Danilo Villalta, Grazia Sepiacci, Gianfranco Santini, Ettore Bartoli
Journal: New England Journal of Medicine (1992)

The pathophysiologic aspects of pruritus in patients with chronic renal insufficiency are poorly understood, and there is no universally effective treatment. The improvement of pruritus in several patients receiving erythropoietin therapy raised the possibility that erythropoietin affects uremic pruritus directly.
La sphinctérotomie endoscopique est-elle évitable chez les patients présentant une dysfonction du sphincter d'Oddi?
Authors: M Barthet, V Vitton, R Delpy, N Lesavre, M Gasmi, E Abou-Berdugo, A Desjeux, JC Grimaud
Journal: Endoscopy (2005)

La sphinctérotomie endoscopique (SE) est un traitement efficace (environ 90% d'efficacité dans la littérature) mais dangereux avec un risque de pancréatite dépassant 20% dans cette indication. Le but de ce travail prospectif était d'évaluer la fréquence de l'indication de SE dans un groupe de patients présentant une DSO pris en charge avec le même algorithme diagnostique et thérapeutique.
Oxidative Stress Responses to the Fungal Allergen Alternaria Mediate IL-33 Secretion By Airway Epithelial Cells and Type 2 Immunity in the Airways
Authors: Koji Iijima, Takao Kobayashi, Masaru Uchida, Erik L. Anderson, Diane Squillace, Gail M. Kephart, Scott M. O'Grady, Hirohita Kita
Journal: Journal of Allergy and Clinical Immunology (2016)
Case 14-1995
Authors: R.T. Cotton, M.L. Goodman
Journal: New England Journal of Medicine (1995)

Presentation of CaseA 12-year-old boy was admitted to the hospital because of an obstructive right nasal mass.The patient had been in excellent health until two years earlier, when he began to have right nasal obstruction that gradually worsened. Occasional bouts of epistaxis occurred; right-sided headaches appeared and interfered with his attendance at school and concentration. Treatment for sinusitis on several occasions and the topical use of beclomethasone did not result in improvement. Four months before admission an otolaryngologist detected an obstructive polypoid mass within the right nasal cavity. Axial and coronal computed tomographic (CT) sections of the paranasal . . .
Case 33-1999
Authors: Robert D. Pugatch, Eugene J. Mark
Journal: New England Journal of Medicine (1999)

Presentation of CaseA 57-year-old woman was admitted to the hospital because of a pulmonary mass in the left lower lobe.The patient had been well until seven weeks earlier, when a respiratory infection developed, with chilliness and a cough productive of small amounts of clear sputum. Treatment with an antibiotic was ineffective. Radiographs of the chest, obtained elsewhere, showed a spicular mass, 3 cm in diameter, in the left lower lobe. A computed tomographic (CT) scan of the chest and upper abdomen, obtained without the administration of contrast material, confirmed the presence of the spicular mass, with surrounding ground-glass . . .
Case 6-1977
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, William E. Strole, James J. Galdabini
Journal: New England Journal of Medicine (1977)

Presentation of CaseA 17-year-old girl was admitted to the hospital because of hepatic enlargement.She was well until seven months previously, when progressive pruritus and fatigue began to develop. Trimeprazine was prescribed. Her symptoms slowly worsened until four months before entry, when she experienced a right-sided abdominal ache that was aggravated by movement. Nausea, vomiting and anorexia occurred, and her menses ceased. She entered another hospital, where examination revealed icterus and enlargement of the liver to the level of the iliac crest. The conjugated bilirubin was 5.4 mg, the total bilirubin 9.6 mg, the cholesterol 420 mg, and the . . .
Outbreak of 2009 Pandemic influenza A (H1N1) on a Peruvian Navy ship - June-July 2009.
Authors: D. M. Vera, V. Gonzaga, R. A. Hora, M. Ramos, C. L. de Mola, J. M. Neyra, C. Sanchez, T. Kochel, M. J. Sklar, J. M. Montgomery, J. A. Quispe, F. Bringas, M. Céspedes, S. González, M. Larru, M. Fernández, D. Faix, C. Meyers, P. Blair, P. Mote, D. L. Blazes, T. Quandelacy
Journal: MMWR Morbidity and Mortality Weekly Report (2010)
Prevention of Nitroprusside-Induced Cyanide Toxicity with Hydroxocobalamin
Authors: James E. Cottrell, Pierre Casthely, Jonathan D. Brodie, Katie Patel, Anne Klein, Herman Turndorf
Journal: New England Journal of Medicine (1978)

To investigate hydroxocobalamin's role in preventing cyanide intoxication from sodium nitroprusside, we studied two groups of patients. One group received nitroprusside alone, and the other received nitroprusside and hydroxocobalamin. Red-cell and plasma cyanide levels were 83.44 +/- 23.12 and 3.51 +/- 1.01 microgram per 100 ml after nitroprusside alone and were 33.18 +/- 17.29 and 2.18 +/- 0.65 microgram per 100 ml after nitroprusside plus hydroxocobalamin. Acidosis developed in patients with red-cell cyanide levels higher than 75 microgram per 100 ml. When hydroxocobalamin infusion was stopped before sodium nitroprusside infusion was discontinued, blood cyanide levels and base deficit increased in a manner similar to that in the untreated group. The dose of nitroprusside used in each group did not differ statistically. These data show that hydroxocobalamin prevents cyanide transfer from red cells and plasma to tissue after nitroprusside metabolism, and thereby prevents cyanide toxicity from large intravenous doses of the drug.
Phase II study of chemoradiotherapy with docetaxel for elderly patients with stage II / III esophageal carcinoma
Authors: Akihiro Ohba, Ken Kato, Yoshinori Ito, Chikatoshi Katada, Hiromichi Ishiyama, Sachiko Yamamoto, Takashi Ura, Takeshi Kodaira, Shigehiro Kudo, Takayuki Nakamura
Journal: Annals of Oncology (2015)
Potentiation of Acetohexamide Hypoglycemia by Phenylbutazone
Authors: James B. Field, Meisei Ohta, Constance Boyle, Adrienne Remer
Journal: New England Journal of Medicine (1967)

PROLONGED and profound hypoglycemia has occasionally been reported in patients who have been taking the sulfonylurea agents.1 2 3 4 5 6 7 8 9 10 11 12 13 This syndrome has not been restricted to diabetic patients, since these drugs have also been used for treatment of other conditions such as Parkinsonism.1 Hypoglycemia has been observed with tolbutamide, chlorpropamide and acetohexamide. Usually, it has occurred in elderly patients during the initial period of therapy and with doses of the sulfonylurea considered to be in the therapeutic range. The hypoglycemia may persist for as long as ninety-six hours2 and may be quite profound, with blood glucose levels as low as 9 mg . . .
Acute Vascular Purpura Following Immunization with Asiatic-Influenza Vaccine
Authors: Mario Stefanini, Sergio Piomelli, Rose Mele, Joseph T. Ostroski, William P. Colpoys
Journal: New England Journal of Medicine (1958)

THIS paper describes the occurrence of acute vascular purpura in a patient who received polyvalent Asiatic-influenza vaccine. The vasculitic process appeared to be due to an antigen–antibody reaction, the antibody being presumably formed in response to the antigenic stimulus of the vaccine. Because of the apparent rarity of this complication, it was believed that its reporting might call attention to similar cases and alert physicians to such a possibility.Case ReportMiss M. R., a 37-year-old secretary, received intradermally in each deltoid area 1 ml. of a commercial polyvalent influenza vaccine** on October 28, 1957. Three days later blepharoconjunctivitis developed . . .
Response to Letter Regarding Article, “Mitomycin-Induced Pulmonary Veno-Occlusive Disease: Evidence From Human Disease and Animal Model”
Authors: Frédéric Perros, Sven Günther, Benoit Ranchoux, Laurent Godinas, Fabrice Antigny, Marie-Camille Chaumais, Peter Dorfmüller, Aurélie Hautefort, Nicolas Raymond, Laurent Savale, Xavier Jaïs, MD Barbara Girerd, Vincent Cottin, Olivier Sitbon, Gerald Simonneau, Marc Humbert, David Montani
Journal: Circulation (2016)
<sup>18</sup>F-fluorodeoxyglucose PET/CT added to screening after unprovoked VTE did not increase cancer detection
Authors: Thomas DeLoughery
Journal: Annals of Internal Medicine (2016)

Source Citation Robin P, Le Roux PY, Planquette B, et al; MVTEP study group. Limited screening with versus without 18 F-fluorodeoxyglucose PET/CT for occult malignancy in unprovoked venous thromboembolism: an open-label randomised controlled trial. Lancet Oncol. 2015;17:193-9. 26672686
Antihistaminic Therapy for Gingival Hyperplasia Due to Dilantin
Authors: R. A. Gaillard
Journal: New England Journal of Medicine (1957)

GINGIVAL hyperplasia is a common side reaction to diphenylhydantoin sodium (Dilantin) therapy for epilepsy, being reported in 50 per cent to over 60 per cent of cases.1 2 3 The most successful management, besides stopping Dilantin therapy, is conservative periodontal treatment4 , 5 although gingivectomy has been used.5 6 7 No successful drug therapies have been reported. In the following cases 2 patients responded successfully to antihistaminic therapy employing chlorprophenpyridamine maleate (Teldrin Spansule capsules).Case ReportsCase 1. A 12-year-old boy had been receiving Dilantin for several years. When he was first seen, his teeth were almost completely covered by his gingiva. His presenting complaint was . . .
The Practical Importance of Modern Concepts of Psychosomatic Relations
Authors: Alfred O. Ludwig
Journal: New England Journal of Medicine (1948)

THE term psychosomatic in its present-day usage serves commonly to designate a group of diseases with organic changes in which emotion is thought to play an important etiologic role. It is unfortunate, however, that there is a tendency to think of this approach as constituting still another specialty within the body of medicine. It would be far healthier if a broader concept could be adopted in which the attempt to study and describe both the physical and emotional aspects of illness could be viewed as a step toward the unification of all medical knowledge as it pertains to disease in . . .
Increased Tumorigenesis Induced by&lt;italic&gt;N&lt;/italic&gt;-Nitrosobis(2-oxopropyl)amine in Syrian Golden Hamsters Fed High-Fat Diets1.&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;&lt;xref ref-type="fn" rid="FN3"&gt;3&lt;/xref&gt;
Authors: Diane F. Birt, Parviz M. Pour
Journal: JNCI Journal of the National Cancer Institute (1983)

The effects of dietary fat on carcinogenesis were presented, with the pancreas excluded, in randombred Syrian golden hamsters after administration of N-nitrosobis(2-oxopropyl)amine (BOP). Diets containing 4.5, 9, or 18 g corn oil/385 kilocalories [Iowfat (LF), medium-fat (MF), or high-fat (HF) diet, respectively] were fed in two sequences. In the first sequence during which the effects of fat on the initiation phase of BOP carcinogenicity were examined, LF or HF diets were fed to hamsters 3-7 weeks of age and for 2 days after a single sc BOP treatment (1 0 mg/kg body wt) to 8-week-old hamsters. These hamsters were then given MF diet for the remainder of their lives. In the second sequence during which the role of fat on the promotional phase (development) of BOP-induced cancer was evaluated, MF diet was fed during the weeks preceding BOP treatment and LF or HF levels were given after BOP treatment. Separate groups were fed MF diet throughout both phases, and parallel animal groups received each diet sequence and were treated with saline at 8 weeks of age. Renal adenocarcinomas in males were observed only in those given HF diet either before or after BOP treatment (9% incidence). Similarly, pulmonary adenoma and intraphepatic biliary cystic adenoma (cholangioma) incidences were elevated above spontaneous rates in HF-fed groups. This study demonstrated that dietary fat enhanced BOP-induced tumorigenesis in the kidneys, lungs, and liver when fed, either during initiation (preceding carcinogen treatment) or at promotional stages (following carcinogen treatment).
Critical Evaluation of Massive Steroid Therapy of Acute Leukemia
Authors: Edward Shanbrom, Sherwood Miller
Journal: New England Journal of Medicine (1962)

THE fact that adrenocortical hormones can be of considerable benefit in acute leukemia has long been recognized. In recent years a number of investigators have attempted to enhance the effectiveness of these hormones by administering massive doses.1 2 3 4 5 6 7 8 9 The individual series reported, however, have generally been small, and the type of leukemia has not always been clearly classified. It was the purpose of this study to evaluate the efficacy of massive steroid therapy in acute leukemia and to observe any variations in the effectiveness of adrenocortical hormones in different types of leukemia. Preliminary observation had led us to believe that further . . .