tbuckley/cabot-search huggingface dataset:
PTH-137 An Impact Analysis: Expansion of the Gastroenterology Reach in Service to Acute Medicine: Abstract PTH-137 Table 1
Authors: A Vaziri, R Chaudhary
Journal: Gut (2016)

<h3>Introduction</h3> The gastroenterology team at Watford General Hospital provides a daily reach in service to the acute medical department every weekday morning. The role of these reviews is to expedite specialist input to patients acutely admitted to the hospital with the aim of improving clinical outcomes and time to discharge. A proposal has been suggested to provide an evening service in addition with a gastroenterology reach in at 5 pm on weekdays to provide a second round of reviews to patients who may have been identified as needing specialist input since the morning round. In order to provide such a service resources (Consultant or Specialist Registrar time) will need to be diverted from other pressured clinical work such as clinics or endoscopy. The aim of this report is assess the potential utility of providing such a service so as to better inform future decisions on the topic. <h3>Methods</h3> On behalf of the gastroenterology department the author has collected data on patients flagged as requiring gastroenterological input on 7 consecutive weekdays from the 07/12/2015 to 15/12/2015. The notes were briefly reviewed and an assessment was made on the basis of this as to the likelihood of the patient being immediately discharged following specialist input. <h3>Results</h3> There were no referrals for gastroenterology review on 3 of the 7 evenings assessed. The range of case numbers referred on other days was between 1 and 3. It was not felt that any of the patients would have had a same day discharge if gastroenterological review was provided due to a variety of factors such as frailty, pending radiological or serological testing or ongoing poorly controlled symptoms. The breakdown of patient demographics and presentations are summarised in the table below. <h3>Conclusion</h3> Overall in the authors opinion following analysis of the collected data an evening review is unlikely to result in a significant increase same day discharges. The likely time and resource commitment is probably unlikely to result in significant improvement in clinical outcomes given the already intense input the gastroenterology department has every weekday morning with the reach in services to the acute medical unit as well as the liaison the gastroenterology registrars provide for urgent cases in the afternoon and the provision of specialist opinion at local tertiary hospitals via telephone out of hours. <h3>Disclosure of Interest</h3> None Declared
AB0849 Spinal Brucellosis: A Study of 40 Cases in A Tunisian Hospital
Authors: H. Ajlani, S. Rekik, S. Boussaid, H. Sahli, E. Cheour, M. Elleuch
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Brucellosis is a major health problem in Mediterranean countries, including Tunisia. The clinical presentation of this zoonosis varies considerably, but osteoarticular involvement and spinal brucellosis particularly, is the commonest complication. <h3>Methods</h3> This study was carried out between 2006 and 2013. Forty patients with infectious spondylodiscitis hospitalized in the department of Rheumatology were analyzed. All patients were thoroughly interrogated, subjected to a rigorous clinical examination and a battery of investigations including: complete blood count, urine analysis, blood culture, erythrocyte sedimentation rate, C-reactive protein (CRP) and serology for brucellosis. The imaging ordered including: plain X-ray of the lumbosacral spine, bone scan and magnetic resonance imaging (MRI) with contrast enhancement of the spine. <h3>Results</h3> Ten of the forty patients (25%) proved to have spinal brucellosis. The mean age of this patients was 51 years (range 15 – 68 years) and female/male ratio: 1,5. The mean delay of diagnosis was 7 months. The following symptoms were observed: fever in 9 patients and back pain in all patients. Other symptoms were less frequently observed, such as splenomegaly (one patient), peripheral adenopathy (two patients) and diarrhoea (one patient). Laboratory exams showed elevated erythrocyte sedimentation rate in most of them (8 patients), high levels of CRP in all patients and leukocytosis in 7 cases. Wright serology was positive in all of them. Brucella melitensis was isolated in blood cultures in 2 cases. Standard X-rays were performed in all patients; they showed signs of spondylodiscitis in the lumbar spine in 5 cases, cervical in one case and dorsal in two cases. CT-scan and MRI confirms the diagnosis and showed associated epiduritis (3cases) or abscess (4 cases). Bone biopsy and histopathological examination were performed in three cases. A combination of cycline and rifampicin was given to all patients. The duration of therapy was between 6 and 8 weeks. <h3>Conclusions</h3> Brucellosis is present with various clinical signs in endemic areas and may simulate many diseases. The need for prompt diagnosis and treatment of spinal brucellosis is of the utmost importance to prevent serious bone destruction and severe neurologic sequelae. <h3>Disclosure of Interest</h3> None declared
AB0434 The Role of IGG Anti β2-GPI in The Clinical Manifestations of Systemic Lupus Erythematosus
Authors: B. Mahendran, R. Sankalingam, K. Mohanasundaram, S. Sankaran, M. Mani, B. Chilukuri
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Beta 2 GPI is an important antigenic target for antiphospholipid antibodies. The role of IgG antibodies to β2 glycoprotein I [Anti-β2-GPI] has been well defined in antiphospholipid antibody syndrome but its role in the clinical manifestions of SLE remains elusive. <h3>Objectives</h3> To investigate the role of Anti-β2-GPI in the clinical manifestations of SLE <h3>Methods</h3> IgG Anti-β2-GPI was measured in 184 patients with SLE (93% women, mean age 28 years). IgG Anti-β2-GPI (&gt;18 GPL units) was found in 19 patients (10.3%). Associations were determined with clinical manifestations of SLE and with components of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Index <h3>Results</h3> Of the patients with SLE who demonstrated IgG Anti-β2-GPI, 31% had at least one thrombotic event (OR 4.2, p=0.01), 26% had pulmonary hypertension (OR 3.2, p=0.02) and 26% had recurrent abortions (OR 4.1, p=0.02). IgG Anti-β2-GPI was protective against lupus nephritis (OR 0.31, p=0.02). No other manifestations were significantly higher in patients with IgG Anti-β2-GPI positivity <h3>Conclusions</h3> In SLE, IgG Anti-β2-GPI is associated with thrombotic events and pulmonary hypertension, but may have a protective effect against lupus nephritis. Large scale studies are required to confirm these findings. <h3>References</h3> Vikerfors A, Johansson AB, Gustafsson JT, Jönsen A, Leonard D, Zickert A et al. Clinical manifestations and anti-phospholipid antibodies in 712 patients with systemic lupus erythematosus: evaluation of two diagnostic assays. Rheumatology (Oxford). 2013 Mar;52(3):501–9. Meroni PL, Raschi E, Grossi C, Pregnolato F, Trespidi L, Acaia B et al. Obstetric and vascular APS: same autoantibodies but different diseases? Lupus. 2012 Jun;21(7):708–10. Matsuura E, Shen L, Matsunami Y, Quan N, Makarova M, Geske FJ et al. Pathophysiology of beta2-glycoprotein I in antiphospholipid syndrome. Lupus. 2010 Apr;19(4):379–84. <h3>Disclosure of Interest</h3> None declared
Rare Coding Single Nucleotide Variants of ADAMTS13 Are Associated with Deep Vein Thrombosis in a Next-Generation Sequencing Association Study
Authors: Luca Andrea Lotta, Giacomo Tuana, Jin Yu, Ida Martinelli, Mark Wang, Fuli Yu, Serena Maria Passamonti, Emanuela Pappalardo, Walker Hale IV, Donna M. Muzny, Frits R. Rosendaal, Richard A Gibbs, Flora Peyvandi
Journal: Blood (2012)
Dendritic Cells Loaded with Treating Myeloma Cells with Combination of JSI-124 and Bortezomib Can Generate Potent Myeloma-Specific CTLs Through Recovering Dysfunction of Dendritic Cells in Myeloma Patients
Authors: Youn-Kyung Lee, Mi-Hyun Kim, Cheol Yi Hong, Mi-Hyun Lim, Thanh-Nhan Nguyen-Pham, Chun-Ji Jin, Hyun Ju Lee, Deok-Hwan Yang, Sung-Hoon Jung, Jae-Sook Ahn, Soo-Young Bae, Yeo-Kyeoung Kim, Ik-Joo Chung, Tai Ju Hwang, Hyeoung-Joon Kim, Je-Jung Lee
Journal: Blood (2011)
Eradication and Reduction of the Abnormal Chromosome 7 Clone with Azacitidine (AZA C) Is Achievable for One-Third of Patients (pts) with Myelodysplastic Syndrome (MDS).
Authors: Vesna Najfeld, Angela Scalise, Rosalie Odchimar-Reissig, Lewis R. Silverman
Journal: Blood (2007)
OC-067 Different Mechanisms of Disease in Subtypes of Irritable Bowel Syndrome as Demonstrated by MRI: Abstract OC-067 Table 1
Authors: C Lam, G Chaddock, L Marciani, C Costigan, E Cox, C Hoad, S Pritchard, P Gowland, R Spiller
Journal: Gut (2016)

<h3>Introduction</h3> The study of irritable bowel syndrome (IBS) has been hampered by the absence of biomarkers to accurately categorise subgroups of this heterogeneous condition. Our aim was to assess gut transit, small bowel water content and colonic regional volumes of different clinically defined IBS subtypes both fasted and post-prandially using MRI scans. <h3>Methods</h3> 91 subjects were recruited (34 healthy volunteers (HV), 30 IBS with diarrhoea (IBS-D), 16 IBS with constipation (IBS-C) and 11 IBS with mixed bowel habit (IBS-M). Subjects underwent MRI scans every 45 min on the study day. Whole gut transit times (WGTT), small bowel water content (SBWC) and regional colonic volumes were assessed as previously described<sup>1,2,3</sup>. Abdominal symptoms were scored using visual analogue score questionnaires after each set of MRI scans. Breakfast was given before t = 0 and lunch after t = 360 min. Postprandial assessment is timed between t = 0 to t = 360 min. <h3>Results</h3> (See Table 1). Fasting and postprandial SBWC area under the curve (AUC) in IBS-D and IBS-M were significantly less than HV, p = 0.02 &amp; p &lt; 0.01 (1 way ANOVA) respectively. The fasting transverse colon volume in IBS-C was significantly larger compared to HV, IBS-D and IBS-M p = 0.02 (Kruskal-Wallis). The AUC postprandial total colonic volume for IBS-C was significantly larger than HV and IBS-D, p = 0.03(Kruskal-Wallis). The WGTT for IBS-C was significantly longer than HV and IBS-D, p = 0.02(Kruskal-Wallis). There was significant correlation between bloating score (VAS 0–10 cm) and transverse colon volume after lunch (t = 405 min) with spearman r = 0.21, p = 0.04. <h3>Conclusion</h3> The constricted small bowel in IBS-D &amp; IBS-M and the dilated transverse colon in IBS-C point to significant differences in underlying mechanisms of disease in these IBS subtypes. <h3>References</h3> 1 Chaddock G, <i>et al</i>. <i>Neurogastroenterol Motil</i> 2014;<b>26</b>:205–214. 2 Pritchard SE, <i>et al</i>. <i>Neurogastroenterol Motil</i> 2014;<b>26</b>:124–30. 3 Hoad CL, <i>et al</i>. <i>Phys Med Biol</i> 2007;<b>52</b>:6909–22. <h3>Disclosure of Interest</h3> C. Lam: None Declared, G. Chaddock: None Declared, L. Marciani: None Declared, C. Costigan: None Declared, E. Cox: None Declared, C. Hoad: None Declared, S. Pritchard: None Declared, P. Gowland: None Declared, R. Spiller Grant/research support from: Lessafre and Ironwood, Consultant for: Almirall, Yuhan Corporation,Ibsen and Danone, Speaker bureau with: Menarini
Comparison of Real-World Treatment Patterns and Clinical Outcomes in 18-59 Year-Old Patients with FLT3 Mutated Vs. FLT3 Wild Type Acute Myeloid Leukemia: A Medical Records Review
Authors: Jipan Xie, Emily Goldmann, Anuja Roy, Chelsey Yang, Eric Q Wu, Carole Paley
Journal: Blood (2014)
Prioritizing Pediatric Drug Research Using Population-Level Health Data
Authors: James A. Feinstein, Elaine H. Morrato, Chris Feudtner
Journal: JAMA Pediatrics (2016)

This Viewpoint discusses updating the Priority List of drugs requiring further study in children by using population-level health data to address 5 key considerations: the prevalence of disease, patterns of drug use, adverse drug events, drug-drug interactions, and drugs with potential for misuse.
Abstract 11909: Migraine Headaches and Cardiovascular Outcomes in Women With Symptoms and Signs of Ischemic Heart Disease: Results of an Extended follow-up From the Women’s Ischemia Syndrome Evaluation
Authors: Cecil A Rambarat, Islam Y Elgendy, B. Delia Johnson, Carl J Pepine, C Noel Bairey Merz, Vera A Bittner, Steven E Reis, Diane V Thompson, Bina Ahmed
Journal: Circulation (2016)

Introduction: Data regarding the association between migraine headaches (MH) and cardiovascular (CV) events in women have been inconsistent. The aim of this study was to determine the long-term risk of CV events among women with and without MH who were evaluated for suspected ischemic heart disease (IHD) in the Women’s Ischemia Syndrome Evaluation (WISE) Study. Methods: Women reporting a history of MH were identified from the WISE cohort. Extended follow-up data were available for a median follow-up of 6 years. Cox proportional adjusted hazard ratios (HR) were constructed for time to first adverse CV event (CV death, non-fatal myocardial infarction [MI], heart failure hospitalization, or non-fatal stroke) among women with and without MH. Additionally, HR were determined for each event separately, as well as, all-cause death, angina hospitalization, death or MI, and CV death or MI. Results: Data on self reported MH were available on 917 women. A total of 224 (24.4%) reported a history of MH. Compared to those who did not report a history of migraines, women with a history of MH had an increased adjusted* risk of CV events (HR 1.83 CI 1.22-2.75, p=0.004) at a median follow up of 6-years. This result was mainly due to an increase in the risk of stroke (HR 2.33 CI 1.16-4.68, p=0.018) (Table 1). Conclusion: Among women being evaluated for IHD, those who reported a history of MH had an increased risk of future CV event. This finding was primarily driven by the more than 2-fold increased risk of stroke.
Prognostic Value of Rare IKZF1 deletions in Childhood B-Cell Precursor Acute Lymphoblastic Leukemia: An International Collaborative Study
Authors: Judith M. Boer, Arian van der Veer, Dimitris Rizopoulos, Marta Fiocco, Edwin Sonneveld, Hester A. de Groot-Kruseman, Roland P. Kuiper, Peter M. Hoogerbrugge, Martin A. Horstmann, Marketa Zaliova, Chiara Palmi, Jan Trka, Eva Fronkova, Mariana Emerenciano, Maria do Socorro Pombo-de-Oliveira, Wojciech Mlynarski, Tomasz Szczepanski, Karin Nebral, Andishe Attarbaschi, Nicola C. Venn, Rosemary Sutton, Claire Schwab, Amir Enshaei, Ajay J. Vora, Martin Stanulla, Martin Schrappe, Gianni Cazzaniga, Valentino Conter, Martin Zimmerman, Anthony V. Moorman, Rob Pieters, Monique L. Den Boer
Journal: Blood (2014)
Subcutaneous Alemtuzumab Combined with Oral Dexamethasone, Followed by Alemtuzumab Maintenance or Allo-SCT In CLL with 17p- or Refractory to Fludarabine – Interim Analysis of the CLL2O Trial of the GCLLSG and FCGCLL/MW
Authors: Stephan Stilgenbauer, Florence Cymbalista, Véronique Leblond, Alain Delmer, Thorsten Zenz, Dirk Winkler, Andreas Bühler, Silja Mack, Raymonde Busch, Stefan Ibach, Sylvain Choquet, Caroline Dartigeas, Bruno Cazin, Olivier Tournilhac, Michael Rieger, Martin Sökler, Till Seiler, Johannes Schetelig, Peter Dreger, Michael Hallek, Hartmut Döhner
Journal: Blood (2010)
Understanding kidney care needs and implementation strategies in low- and middle-income countries: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference
Authors: Vivekanand Jha, Mustafa Arici, Allan J. Collins, Guillermo Garcia-Garcia, Brenda R. Hemmelgarn, Tazeen H. Jafar, Roberto Pecoits-Filho, Laura Sola, Charles R. Swanepoel, Irma Tchokhonelidze, Angela Yee Moon Wang, Bertram L. Kasiske, David C. Wheeler, Goce Spasovski, Lawrence Agodoa, Ghazali Ahmad, Vathsala Anantharaman, Fatiu Arogundade, Gloria Ashuntantang, Sudarshan Ballal, Ebun Bamgboye, Chatri Banchuin, Boris Bogov, Sakarn Bunnag, Worawon Chailimpamontri, Ratana Chawanasuntorapoj, Rolando Claure-Del Granado, Somchai Eiam-Ong, Lynn Gomez, Rafael Gómez, Dimitrios Goumenos, Hai An Ha Phan, Valentine Imonje, Atiporn Ingsathit, Faiçal Jarraya, Sirin Jiwakanon, Surasak Kantachuvesiri, Umesh Khanna, Vijay Kher, Kamol Kitositrangsikun, Zhi-Hong Liu, Pichet Lorvinitnun, Nazaire Nseka, Gregorio T. Obrador, Ikechi Okpechi, Duangta Onsuwan, Vuddhidej Ophascharoensuk, Charlotte Osafo, David Peiris, Warangkana Pichaiwong, Kearkiat Praditpornsilpa, Mohan Rajapurkar, Ivan Rychlik, Gamal Saadi, Vicente Sanchez Polo, Pornpen Sangthawan, Nirut Suwan, Vladimir Tesar, Prapaipim Thirakhupt, Thananda Trakarnvanich, Yusuke Tsukamoto, Kriang Tungsanga, Supat Vanichakarn, Evgueniy Vazelov, Christoph Wanner, Anthony Were, Elena Zakharova
Journal: Kidney International (2016)

Evidence-based cinical practice guidelines improve delivery of uniform care to patients with and at risk of developing kidney disease, thereby reducing disease burden and improving outcomes. These guidelines are not well-integrated into care delivery systems in most low- and middle-income countries (LMICs). The KDIGO Controversies Conference on Implementation Strategies in LMIC reviewed the current state of knowledge in order to define a road map to improve the implementation of guideline-based kidney care in LMICs. An international group of multidisciplinary experts in nephrology, epidemiology, health economics, implementation science, health systems, policy, and research identified key issues related to guideline implementation. The issues examined included the current kidney disease burden in the context of health systems in LMIC, arguments for developing policies to implement guideline-based care, innovations to improve kidney care, and the process of guideline adaptation to suit local needs. This executive summary serves as a resource to guide future work, including a pathway for adapting existing guidelines in different geographical regions.
Dynamics and Characteristics of BCR-ABL Multiple Mutations In Tyrosine Kinase Inhibitor Resistant Chronic Myeloid Leukemia.
Authors: Dong-Wook Kim, Dongho Kim, Soo-Hyun Kim, Saengsuree Jootar, Hyun-Gyung Goh, Jeong Lee, Soo-Young Choi, Young-Seok Lee, Sang-Mi Oh
Journal: Blood (2010)
Aberrant Gene Expression of BAALC and ERG in Older [≥60 Years (y)] De Novo Cytogenetically Normal Acute Myeloid Leukemia (CN-AML): A Cancer and Leukemia Group B (CALGB) Study.
Authors: Sebastian Schwind, Guido Marcucci, Kati Maharry, Krzysztof Mrózek, Michael D. Radmacher, Kelsi B. Holland, Heiko Becker, Susan P. Whitman, Yue-Zhong Wu, Maria R Baer, Bayard L. Powell, Andrew J. Carroll, Michael A. Caligiuri, Richard A. Larson, Clara D. Bloomfield
Journal: Blood (2009)
Subcutaneous Injections of IMMU-114 (Anti-HLA-DR IgG4 Monoclonal Antibody): Initial Results of a Phase I First-in-Man Study in Hematologic Malignancies
Authors: Deborah M. Stephens, Alexander N Starodub, John C Byrd, Heather Horne, William A Wegener, David M Goldenberg, Beth A Christian
Journal: Blood (2015)
Target Epitopes of Human T Lymphotropic Virus 1 Recognized by Class I MHC-Restricted Cytotoxic T Lymphocytes in HAM/TSP Patients and Infected Patients with Autoimmune Disorders.
Authors: Tomohiro Kozako, Masaki Akimoto, Yohann White, Shingo Toji, Kakushi Matsushita, Ryuji Kubota, Shuji Izumo, Shinsuke Suzuki, Kimiharu Uozumi, Hiroshi Shimeno, Shinji Soeda, Naomichi Arima
Journal: Blood (2009)
Telomere Length Reduction in Patients with Early Myelodysplastic Syndrome (MDS) Is Connected with Presence of Karyotype Abnormalities and with Shortened Survival and May Serve as an Additional Prognostic Factor.
Authors: Zuzana Sieglova, Jaroslav Cermak, Sona Zilovcova, Hana Zizkova, Kyra Michalova
Journal: Blood (2004)
Toxicity and Early Response after Single Daily Dose of Intravenous Busulfan and Melphalan as Conditioning Regimen for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma.
Authors: Margarita Blanes, Javier de la Rubia, Juan J. Lahuerta, Juan D. Gonzalez, Paz Ribas, Carlos Solano, Miguel A. Sanz
Journal: Blood (2007)
SP0086 Tissue Specific Differentiation of Intestinal Macrophages
Authors: A. Mowat
Journal: Annals of the Rheumatic Diseases (2016)

Resident macrophages (møs) from different tissues are highly heterogeneous in terms of their functions and origins. Intestinal møs are one of the largest populations in the body and have several characteristic features, including expression of high levels of MHCII and CX3CR1, constitutive production of IL10 and TNFa and avid phagocytic activity. However they are refractory to stimuli such as TLR ligands. We have shown that adult intestinal møs are derived from circulating Ly6Chi monocytes that acquire the properties of the resident cells in the mucosa. However the mechanisms responsible for this local differentiation process are unknown. By comparing their transcriptome with monocyte- and embryonically derived møs from other tissues, here we identify a genetic signature of resident intestinal møs and validated it by Q-PCR and FACS. Soon after entry into the intestine, maturing møs become genetically distinct, even from møs in other tissues that are replenished by monocytes, such as the dermis. Many of the selectively expressed molecules are involved in tissue remodeling and in uptake of apoptotic cells, including avβ5 integrin, metalloproteases 2, 9 &amp; 14, C1Q and CD36. Several are TGFβ inducible genes and although intestinal møs numbers are normal in CD11c-cre-TGFβR1fl/fl mice, their gene signature is altered and they show reduced expression of IL10 and CX3CR1. In parallel, chimeric mice lacking TGFβR signaling only on møs show evidence of increased inflammatory monocyte recruitment. Thus TGFβR signaling is critical for tissue specific adaptation of intestinal møs, driving the differentiation of monocytes into møs with homeostatic and anti-inflammatory functions. <h3>Disclosure of Interest</h3> None declared
A Novel Synthetic GMCSF and IL7 Fusion Cytokine (GIFT7) Leads to T Cell Neogenesis by Reversing Age-Related Thymic Atrophy and Overcoming PD-1-Assocaited CD8 Exhaustion
Authors: Jeremy Hsieh, Colleen McGary, JianHui Wu, Mirko Paiardini, Luca Micci, Anapatricia Garcia, Guido Silvestri, Mohammad Sohrab Hossain, Edmund K. Waller, Jacques Galipeau
Journal: Blood (2012)
Long-Term Homeostatic Effects of Daily Low-Dose IL-2 on CD4+ FoxP3+ Regulatory T Cells in Patients with Active Chronic Graft-Versus-Host Disease
Authors: Jennifer Whangbo, John Koreth, Haesook T. Kim, Katharine Dusenbury, Ana Cristina Alho, Carol G Reynolds, Marie J Chammas, Kyle T Jones, Sarah Nikiforow, Corey S Cutler, Vincent T. Ho, Philippe Armand, Edwin P. Alyea, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz
Journal: Blood (2015)