tbuckley/cabot-search huggingface dataset:
Pain linked to repetitive work
Authors: S P Tyrer
Journal: BMJ (1994)

AEA Technology chosen to be as close as possible to those identified in the case-control study as being at high risk of prostatic cancer.It shows that, while increased mortality from prostatic cancer is detectable in subgroups related to the case-control study, the all cause mortality and all neoplasm mortality in these groups are no different from those in the generality of employees, and most are significantly lower than the national average.The results of the case-control study cannot, therefore, be interpreted as showing an increased occu- pational risk overall.Rather it shows a significantly increased risk for one disease which is not sufficient to detract from a considerable "healthy worker" effect when all mortality is considered.Secondly, we have examined the dosimetric aspects of exposure to the radionucides associated with an increased risk of prostatic cancer in the case-control study, especially zinc-65, the putative carcinogen that attracts most speculation from Rooney and colleagues.When account is taken of the enhanced concentration of zinc-65 in the prostate, the increased radiobiological effectiveness of Auger electrons, the incorporation of these radionuclides into DNA, and practical limits on employees' intake of these radionuclides, radiation doses to the prostate from conceivable levels of contamination with zinc-65 are too low by a factor of about 50-and probably by more than 1000-to account for the observed excess of cases ofprostatic cancer, assuming internationally accepted models of radiation risk.This implies that the radio- nuclides are acting as a surrogate for some other agent.
Statin treatment should be started early
Authors: P. Masters, A. Shetty
Journal: BMJ (1996)

EDITOR,—As doctors who have managed patients with hypercholesterolaemia despite widespread scepticism, particularly in the BMJ,1 we should be feeling pleased that one of our main treatments has been proved safe and effective. However, the results of the recent statin trials2 3 were perhaps too good and we are now told by P D …
Structural and functional heterogeneity of alpha spectrin mutations involving the spectrin heterodimer self-association site: relationships to hematologic expression of homozygous hereditary elliptocytosis and hereditary pyropoikilocytosis
Authors: T Coetzer, J Palek, J Lawler, SC Liu, P Jarolim, M Lahav, JT Prchal, W Wang, BP Alter, G Schewitz
Journal: Blood (1990)
Digoxin is linked to raised risk of death in patients with atrial fibrillation
Authors: J. Wise
Journal: BMJ (2015)

Digoxin is associated with increased mortality in patients treated for atrial fibrillation or heart failure, the largest meta-analysis to review this treatment has concluded. The researchers warned that digoxin should be used with great caution and that patients’ plasma levels should be monitored until randomised controlled trials are carried out.

The study, published in the European Heart Journal ,1 included 19 studies: nine of atrial fibrillation, seven of congestive heart failure, and three of patients with both conditions. …
Abstract 11831: Geographic Distribution of Cardiac Allograft Vasculopathy Associated With Acute Cellular Rejection: A Serial Three-Dimensional IVUS Study of Heart Transplant Recipients
Authors: Kozo Okada, Hideki Kitahara, Hyoung-Mo Yang, Hong-Seok Lim, Kyuhachi Otagiri, Shigemitsu Tanaka, Yuhei Kobayashi, Paul G Yock, Alan C Yeung, Peter J Fitzgerald, Kiran K Khush, William F Fearon, Yasuhiro Honda
Journal: Circulation (2014)

Background: Cardiac allograft vasculopathy (CAV) results from cumulative arterial injury induced by a combination of alloimmune responses and non-specific insults in the context of impaired repair mechanisms. This study aimed to characterize early arterial responses and geographic distribution of CAV associated with acute cellular rejection in heart transplant recipients. Methods: We studied 92 heart transplant recipients who underwent baseline (4-6 weeks post-transplant) and 1-year intravascular ultrasound (IVUS) in the first 50 mm of the left anterior descending (LAD) coronary artery. Average intimal thickness and volumetric IVUS indices for vessel and intima were obtained in 3 equally divided subsegments (proximal, middle, and distal), respectively. Paradoxical arterial remodeling over time was defined as [[Unable to Display Character: ∆]]vessel volume / [[Unable to Display Character: ∆]]intimal volume <0. Acute cellular rejection was defined by endomyocardial biopsy as ISHLT Grade ≥2R. Res...
Usutu virus infection in a patient who underwent orthotropic liver transplantation, Italy, August-September 2009
Authors: F Cavrini, P Gaibani, G Longo, A M Pierro, G Rossini, P Bonilauri, G E Gerunda, F Di Benedetto, A Pasetto, M Girardis, M Dottori, M P Landini, V Sambri
Journal: Eurosurveillance (2009)

We report a case of Usutu virus (USUV)-related illness in a patient that underwent an orthotropic liver transplant (OLT). Post transplant, the patient developed clinical signs of a possible neuroinvasive disease with a significant loss of cerebral functions. USUV was isolated in Vero E6 cells from a plasma sample obtained immediately before the surgery, and USUV RNA was demonstrated by RT-PCR and sequencing. This report enlarges the panel of emerging mosquito-borne flavivirus-related disease in humans.
Abstract 9258: Metabolic Syndrome is Associated with Reduced Myocardial Function Assessed by Speckle Tracking Echocardiography: The Multi-Ethnic Study of Atherosclerosis
Authors: Andre L Almeida, Gisela Teixido-Tura, Eui-Young Choi, Anders Opdahl, Veronica R Fernandes, Colin O Wu, David A Bluemke, Joao A Lima
Journal: Circulation (2010)

Introduction:  Metabolic Syndrome (MeSy) is a cluster of atherogenic risk factors associated with increased cardiovascular morbidity and mortality risk. There is a high prevalence of subclinical cardiovascular disease in subjects with MeSy. Speckle Tracking Echocardiography (STE) is a new non-invasive methods for the assessment of myocardial strain. We assessed the hypothesis that MeSy is associated with subclinical myocardial dysfunction in asymptomatic individuals that may be detected by STE.   Methods:  MeSy was defined according to the modified NCEP ATPIII criteria. We analyzed participants in the MESA study who underwent both STE and MRI tagging (reference method), and who had been evaluated for all MeSy components. Multivariate linear regression was used to evaluate the relationship between STE left ventricular (LV) circumferential strain (Ecc) and MeSy status adjusted for age, gender, ethnicity, LV ejection fraction (LVEF), LV mass index (LVMI), creatinine, and smoking (Model 1). In model 2, ECC by MRI was used as the dependent variable replacing strain determined by STE.   Results:  Of 133 subjects (women: 63%, age: 65±8 yr), MeSy was present in 41 (31%). Presence of MeSy was associated with reduced left ventricular circumferential strain by STE (Ecc= −16.6±3.5 vs −18.5±3.7) and by MRI (Ecc= −15.8±3.4 vs −17.6±2.3) in univariate analysis (p   Conclusion:  Left ventricular circumferential strain evaluated by STE and MRI tagging is reduced in asymptomatic subjects with metabolic syndrome and normal LV ejection fraction and LV mass index. This observation indicates a relationship between metabolic syndrome and subclinical cardiovascular disease in asymptomatic individuals.
FDG positron emission tomographic, radioiodine, and MIBI imaging in a patient with poorly differentiated insular thyroid carcinoma.
Authors: GEORG ZETTINIG, THOMAS LEITHA, BRUNO NIEDERLE, KLAUS KASERER, ALEXANDER BECHERER, KURT KLETTER, ROBERT DUDCZAK
Journal: Clinical Nuclear Medicine (2001)

Poorly differentiated insular thyroid carcinoma is now classified as a separate entity among other tumors of the thyroid gland. Its histologic pattern and its clinical course are regarded as intermediate between well differentiated and anaplastic thyroid cancer. Insular carcinoma accumulates I-131, but no data exist regarding its fluorodeoxyglucose (FDG) positron emission tomographic (PET) uptake. The authors report F-18 FDG PET, Tc-99m MIBI, and radioiodine imaging features in a 63-year-old patient with metastatic insular thyroid carcinoma. After total thyroidectomy (for poorly differentiated insular carcinoma pT3a), the patient was referred for radioiodine ablation. No signs of recurrence were present until 16 months later, when thyroglobulin levels increased. An I-131 scan showed a single lesion in the right lung, and further radioiodine treatment was administered (cumulative dose [530 mCi], 19,610 MBq I-131). Three years after the initial diagnosis, FDG-PET and Tc-99m MIBI scans were performed within 5 days during thyroxine treatment. After that, thyroxine substitution was withdrawn; 6 weeks later, an I-131 whole-body scan was performed. Both radioiodine and MIBI images showed increased tracer uptake in the known lung lesion. However, FDG PET showed a normal tracer distribution. Magnetic resonance and computed tomographic imaging confirmed a 12-mm lesion in the right upper lobe. These findings support the concept of the “flip-flop phenomenon” in insular thyroid carcinoma, an alternating pattern of metastases with either I-131 or FDG-uptake. Despite poorly differentiated histologic findings, glucose metabolism was not increased in this patient with an insular tumor.
Public Health Laboratories
Authors: cdoyle
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
RBC-coupled tPA prevents cerebrovasodilatory impairment and tissue injury in pediatric cerebral hypoxia/ischemia through inhibition of ERK MAPK unregulation
Authors: Kumkum Ganguly, William M Armstead, J W Kiessling, Xiao Han Chen, Douglas H Smith, Abd Ar Higazi, Douglas B Cines, Khalil Bdeir, Sergei Zaitsev, Vladimir R Muzykantov
Journal: Nature Neuroscience (2008)
Essentials of Physical Diagnosis of the Thorax.
Authors: Henry P. De Forest
Journal: JAMA (1896)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Three day versus five day treatment with amoxicillin for non-severe pneumonia in young children: a multicentre randomised controlled trial
Authors: Girdhar Agarwal, Shally Awasthi, S K Kabra, Annapurna Kaul, Sunit Singhi, Stephen D Walter
Journal: BMJ (2004)

To assess the efficacy of three days versus five days of treatment with oral amoxicillin for curing non-severe pneumonia in children.Randomised, double blind, placebo controlled multicentre trial.Outpatient departments of seven referral hospitals in India.2188 children aged 2-59 months, 1095 given three days of treatment and 1093 given five days.Oral amoxicillin 31-54 mg/kg/day in three divided doses.Treatment failure: defined as development of chest indrawing, convulsions, drowsiness, or inability to drink at any time; respiratory rate above age specific cut points on day 3 or later; or oxygen saturation by pulse oximetry < 90% on day 3.The clinical cure rates with three days and five days of treatment were 89.5% and 89.9%, respectively (absolute difference 0.4 (95% confidence interval--2.1 to 3.0)). Adherence to treatment regimen was 94% and 85% for three day and five day treatments, respectively. Loss to follow up was 5.4% by day 5. There were no deaths, 41 hospitalisations, and 36 minor adverse reactions. There were 225 (10.3%) clinical failures and 106 (5.3%) relapses, and rates were similar in both treatments. At enrollment, 513 (23.4%) children tested positive for respiratory syncytial virus, and Streptococcus pneumoniae and Haemophilus influenzae were isolated from the nasopharynx in 878 (40.4%) and 496 (22.8%) children, respectively. Clinical failure was associated with isolation of respiratory syncytial virus (adjusted odds ratio 1.95 (95% confidence interval 1.0 to 3.8)), excess respiratory rate of > 10 breaths/minute (2.89 (1.83 to 4.55)), and non-adherence with treatment at day 5 (11.57 (7.4 to 18.0)).Treatment with oral amoxicillin for three days was as effective as for five days in children with non-severe pneumonia.
Antiplatelet Therapy for Thrombotic Thrombocytopenic Purpura
Authors: G J del Zoppo
Journal: New England Journal of Medicine (1971)

The presence of platelet-fibrin microthrombotic occlusions in the arterioles and capillaries of involved tissues of patients with TTP has suggested a role for platelet aggregation in this disorder. Inhibitors of platelet aggregation have been reported to produce resolution of thrombocytopenia and clinical improvement in many instances. Failure of such agents to produce a clinical effect has been attributed to inadequate dose-duration, severity and extent of end organ/vascular involvement, long-term or secondary effects of the etiologic principal leading to patient deterioration and/or demise. On the other hand, the parallel use of several treatment modalities that themselves may produce clinical effect confounds the interpretation that anti-platelet agents alone may have been responsible for clinical improvement. Nonetheless, complete remission has been reported in a number of TTP patients when the combination ASA/dipyridamole was used alone or together with plasmapheresis, splenectomy, and/or other antiplatelet agents. The evidence for a beneficial clinical effect would seem strongest for the use of this combination early in the course of the disease. More limited and less conclusive has been the experience with sulfinpyrazone, with ticlopidine, and with intravenous PGI2 infusions in TTP. Reports of clear-cut benefit with each of these agents have been rare. Finally, serial dextran infusions have apparently produced amelioration of the clinical syndrome in certain individuals. Assessment of benefit of dextran infusions from retrospective series has been limited by antecedent use of splenectomy. The use of red cell and plasma infusions during splenectomy has been argued to provide some benefit. However, it is likely that dextran can produce definite responses in certain patients. Unfortunately, therapeutic efficacy has been judged from such anecdotal reports and retrospective series. No prospective controlled trials of any of these approaches are available.
Betamethasone: A Dermatological Clinical Evaluation
Authors: J L DANTO, W D STEWART, W S MADDIN, A J NELSON
Journal: JAMA (1963)

The purpose of this study was to determine under carefully controlled clinical conditions the relative anti-inflammatory and anti-pruritic action of betamethasone as compared with prednisone and a placebo. A total of 130 consecutive patients with atopic dermatitis, primary irritant dermatitis, nummular eczema, allergic eczematous contact dermatitis, sweat retention, seborrheic dermatitis and pruritus were selected for study. Under the conditions of this clinical trial, the samples indicated a difference in anti-inflammatory and anti-pruritic response to the therapeutic agents used. The difference between betamethasone and the placebo was highly significant, and the difference in these measured responses was studied on the basis of a careful evaluation and statistically. The result of this study corroborates statistically our clinical impression regarding the therapeutic effect of betamethasone.
Developmental psychiatry comes of age
Authors: J Bowlby
Journal: American Journal of Psychiatry (1988)

Although Meyer and Freud believed that the seeds of mental health are sown in childhood, systematic research has proved difficult and disappointing, and theory has remained intensely controversial. Research of the past two decades by developmental psychologists using an ethologically based theory of socioemotional bonds, however, is yielding findings that consistently confirm predictions. The author outlines this research, giving examples of the results, which are shown to be compatible with findings of epidemiological studies of depressed adults. He holds that a person's degree of vulnerability to stressors is strongly influenced by the development and current state of his or her intimate relationships.
Effects of physical activity in telomere length: Systematic review and meta-analysis
Authors: Eduardo Mundstock, Helen Zatti, Fernanda Mattos Louzada, Suelen Goecks Oliveira, Fátima T.C.R. Guma, Mariana Migliorini Paris, Angélica Barba Rueda, Denise Greff Machado, Renato T. Stein, Marcus Herbert Jones, Edgar E. Sarria, Florencia M. Barbé-Tuana, Rita Mattiello
Journal: Ageing Research Reviews (2015)
Abstract 10392: Relationship Between Zolpidem Use and Acute Myocardial Infarction Risk: A Taiwanese Population-Based Case-Control Study
Authors: Yen-Nien Lin, Po-Yen Ko, Chih-Ping Chang, Chen-Chia Yang, Jen-Jyh Lin
Journal: Circulation (2013)

Objective: To evaluate the relationship between the use of zolpidem and risk of subsequent AMI in Taiwanese patients. Method: This case-control study used data obtained from the National Health Ins...
Public health legislation should be changed
Authors: G H Stewart, S Nelson
Journal: BMJ (1996)

EDITOR,—We were interested in Meirion R Evans's article about tuberculosis in the United Kingdom.1 A problem recently arose in this district concerning the screening of contacts of a patient with multidrug resistant tuberculosis acquired in a nosocomial outbreak in the Chelsea and Westminster Hospital.2 The contacts identified were sent several invitations to attend the tuberculosis screening clinic, but they failed to attend despite intervention by their general practitioners and the tuberculosis health visitor. As a …
Abstract 5986: Drug-Eluting Stent versus Bare Metal Stent Use: Meta-Analysis of Randomized Trials and Observational Studies
Authors: Ajay J Kirtane, Anuj Gupta, Srinivas Iyengar, Roxana Mehran, Jeffrey W Moses, B Martin, Robert Applegate, Edward Hannan, Kishore Harjai, Michael Racz, Lisette O Jensen, S. J Park, Raphael Perry, Francesco Saia, Chuck Simonton, Jack V Tu, Ron Waksman, Gregg W Stone
Journal: Circulation (2008)

Background: The safety and efficacy of drug-eluting stents (DES) among more generalized patient populations than typically enrolled in pivotal randomized controlled trials (RCTs), including for “off-label” indications, is controversial. Objectives: We sought to perform a systematic review and meta-analysis of published/presented DES studies in order to estimate the relative impact of DES vs. BMS particularly outside of USFDA labeled indications, and to specifically assess differences between data derived from RCTs and observational (Obs) analyses. Methods: Studies with &gt;=100 total pts comparing DES to BMS and reporting mortality data with cumulative follow-up of &gt;=1 year that were published and/or presented through 2/2008 were abstracted. Fixed effects and random effects models were used to generate summary estimates of the relative impact of DES vs. BMS upon all-cause mortality, myocardial infarction (MI), and target vessel revascularization (TVR). Data from 9,470 pts enrolled in 22 RCTs and from 182,901 pts studied in 34 Obs studies were included; RCT and Obs data were analyzed separately. Results: Data from “off-label” RCTs demonstrated non-significant reductions in mortality with DES vs. BMS, with a significant reduction in TVR (Table ). The Obs studies (in which pts were treated for both on-label and off-label indications) demonstrated significant reductions in mortality and TVR with DES vs. BMS use (Table ). Conclusions: Use of DES compared to BMS does not appear to be associated with adverse safety outcomes such as death or MI in either off-label RCTs or non-randomized Obs studies, and was associated with a significant and comparable reduction in TVR. In the absence of definitive large-scale randomized data directly comparing DES to BMS in unselected pts, these findings, derived from more than 190,000 total pts treated in 56 studies, suggest that DES are safe and have comparable efficacy in both RCTs and in the “real-world”.
Electron Microscopy of Milk Secretion in the Mammary Gland of the C3H/Crgl Mouse. I. Cytomorphology of the Prelactating and the Lactating Gland&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;
Authors: S. R. Wellings, K. B. Deome, Dorothy R. Pitelka
Journal: JNCI Journal of the National Cancer Institute (1960)

Journal Article Electron Microscopy of Milk Secretion in the Mammary Gland of the C3H/Crgl Mouse. I. Cytomorphology of the Prelactating and the Lactating Gland Get access S. R. Wellings, S. R. Wellings Department of Zoology and Its Cancer Research Genetics Laboratory, University of California, Berkeley, and the Department of Pathology, University of California Medical Center, San Francisco, California Search for other works by this author on: Oxford Academic PubMed Google Scholar K. B. Deome, K. B. Deome Department of Zoology and Its Cancer Research Genetics Laboratory, University of California, Berkeley, and the Department of Pathology, University of California Medical Center, San Francisco, California Search for other works by this author on: Oxford Academic PubMed Google Scholar Dorothy R. Pitelka Dorothy R. Pitelka Department of Zoology and Its Cancer Research Genetics Laboratory, University of California, Berkeley, and the Department of Pathology, University of California Medical Center, San Francisco, California Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 25, Issue 2, August 1960, Pages 393–421, https://doi.org/10.1093/jnci/25.2.393 Published: 01 August 1960 Article history Received: 16 February 1960 Published: 01 August 1960
Abstract 13840: National and Regional Trends in Heart Failure Hospitalization and Mortality Rates for Medicare Beneficiaries: 1998-2008
Authors: Jersey Chen, Sharon-Lise T Normand, Yun Wang, Harlan M Krumholz
Journal: Circulation (2011)

Background: Whether recent declines in ischemic heart disease and its risk factors have been accompanied by declines in heart failure (HF) hospitalization and mortality is not known. We sought to e...