tbuckley/cabot-search huggingface dataset:
Abstract P2-04-01: The role of Jmjd1a in mammary gland development and breast tumor growth
Authors: L Qin, Y Xu, Y Wu, X Yu, MJ Toneff, L Liao, Y Li, J Xu
Journal: Cancer Research (2016)

Abstract Histone modification alters chromatin architecture and thereby influences gene transcription. Histone methylation status is reversible and counter-regulated by methyltransferases and demethylases. Jmjd1a (also known as KDM3A, TSGA, JMJD1, JHDM2A and JHMD2A) is a histone demethylase. It belongs to JmjC domain-containing protein family and could specifically remove di- and mono- methyl residues from di or mono-methylated histone H3K9 (H3K9me2/me1). Recent studies showed that Jmjd1a plays an important role in embryonic stem cell self-renewal, spermatogenesis, regulation of metabolic gene expression and body weight, sex determination, tumor angiogenesis, and macrophage infiltration. However, its role in mammary gland (MG) development, breast carcinogenesis and breast cancer progression hasn't been systemically investigated. In this study, we found that Jmjd1a is expressed in mouse luminal epithelial cells. Genetic disruption of the Jmjd1a gene significantly slowed down MG development as indicated by retarded MG elongation and decreased ductal density in virgin mice observed at the ages of 4, 6 and 8 weeks. In agreement with the retarded MG development, the expression of Ki67 and cyclinD1 in epithelial cells of MGs from Jmjd1a knockout (KO) mice dramatically reduced compared with that from wild type (WT) mice. H3K9me1 and H3K9me2 levels in the epithelial cells of KO MGs are much higher than that in WT MGs. To assess the role of Jmjd1a in breast cancer progression, we crossbred Tg(Jmjd1a-/-) mice with MMTV-TVA(RCAS-PyMT) mice and obtained Tg(Jmjd1a-/-)×MMTV-TVA(RCAS-PyMT) mice. Infection of the TVA-expressing MG epithelial cells with the RCAS-PyMT virus induced mammary tumors in these mice and MMTV-TVA(RCAS-PyMT) control mice. We found that KO of Jmjd1a slightly accelerated mammary tumor initiation but significantly decreased tumor growth. Ki67 and cyclinD1 expression statistically reduced in KO tumors versus WT tumors. At the molecular level, Jmjd1a expression positively correlated with cyclin D1 expression in mammary epithelial cells and mammary tumors. Knockdown of Jmjd1a in MCF-7 cells significantly reduced cyclin D1 expression, while ectopic expression of Jmjd1a in MCF-7 cells increased cyclin D1 expression. ChIP assay revealed that Jmjd1a is associated with a promoter region of cyclin D1. Co-expression of c-Myc and Jmjd1a boosted the activity of the cyclin D1 reporter. In conclusion, our study indicated that Jmjd1a plays an important role in promoting mammary gland development and breast tumor growth by up-regulating cyclin D1 expression. Targeting Jmjd1a may inhibit breast cancer progression. Citation Format: Qin L, Xu Y, Wu Y, Yu X, Toneff MJ, Liao L, Li Y, Xu J. The role of Jmjd1a in mammary gland development and breast tumor growth. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P2-04-01.
Apoptosis of Burkitt's lymphoma cells induced by specific interaction of surface IgM with a self-antigen: implications for lymphomagenesis in acquired immunodeficiency syndrome
Authors: S Roncella, G Cutrona, A Favre, M Ulivi, F Fais, A Signorini, CE Grossi, N Chiorazzi, M Ferrarini
Journal: Blood (1996)
Creutzfeldt-Jakob disease: results of an inquiry in the fifteen Member States of the European Union
Authors: B. C. Merkel, P. W.J Peters, L Chambaud
Journal: Eurosurveillance (1996)

Creutzfeldt-Jakob Disease (CJD) was first described in 1920-1921. CJD is a rare disease with a reported incidence of 0.5 to 1 case per million people in Europe. This fatal dementia belongs to the category of Transmissible Spongiform Encephalopathies (TSE)
Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents
Authors: Jarrad M Scarlett, Jennifer M Rojas, Miles E Matsen, Karl J Kaiyala, Darko Stefanovski, Richard N Bergman, Hong T Nguyen, Mauricio D Dorfman, Louise Lantier, David H Wasserman, Zaman Mirzadeh, Terry G Unterman, Gregory J Morton, Michael W Schwartz
Journal: Nature Medicine (2016)
Abstract IA13: Clonal dynamics of normal and malignant human mammary cell growth in xenografts
Authors: Connie J. Eaves, Long Nguyen, Davide Pellacani, Nagarajan Kannan, Sylvan Lefort, Sneha Balani, Claire Cox, Tomo Osako, Samuel Aparicio, Martin Hirst
Journal: Cancer Research (2016)

Abstract Most human breast cancers have diversified genomically and biologically by the time they become clinically evident and little is known about their origin from normal human mammary cells, or the cellular and molecular mechanisms that lead to their genesis and evolution. We have developed methods to quantify, purify and characterize different subsets of normal human mammary cells and have used these to identify properties that may influence their propensity for transformation. We have also developed methods for inducing the rapid transformation in vivo of these purified subsets following their transplantation into immunodeficient mice. The results demonstrate the ability of a single oncogene (KRASG12D) to induce the formation of serially transplantable, polyclonal, invasive ductal carcinomas within 8 weeks of being introduced either subrenally or subcutaneously into immunodeficient mice. Both primary and secondary tumors are phenotypically heterogeneous and transcriptome analyses of primary tumors assign them to a “normal-like” category. DNA barcoding of the cells at the time of their initial transduction with KRASG12D has revealed a dramatic change in the numbers and sizes of clones they generate after 2 weeks in vivo. DNA barcoding also showed the unexpected appearance of many “new” clones in tumors generated upon passage into secondary recipients, thus recapitulating some features of in vivo passaged human breast cancer cell lines and patients’ tumor xenografts. This system challenges previous concepts about the process of human mammary oncogenesis and provides a new system for analyzing factors that can influence its speed, efficiency and heterogeneity of outcomes. Citation Format: Connie J. Eaves, Long Nguyen, Davide Pellacani, Nagarajan Kannan, Sylvan Lefort, Sneha Balani, Claire Cox, Tomo Osako, Samuel Aparicio, Martin Hirst. Clonal dynamics of normal and malignant human mammary cell growth in xenografts. [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr IA13.
The Content of General Practice
Authors: T O Lim
Journal: BMJ (1962)

Eight general practitioners participated in a survey of content of general practice. This is useful as an indicator or morbidity in the community as well as of workload of general practice. A total of 3164 consultations were recorded, of which 2764 (87%) were because of an illness and the rest (13%) for other reasons like medical examinations, antenatal check, family planning advice, pregnancy tests, pap smear and vaccination. The old and the young have high consultation rates for an illness, men consulted as often as women. The most common illness seen was upper respiratory tract infections, accounting for 37% of all illnesses. Other common minor illnesses were skin infections (6%), genito-urinary infections (5%), minor musculoskeletal (6%) and gastrointestinal (6%) complaints as well as minor injuries and cuts (4%). Major disorders form an unusually low proportion (18%) of all illnesses seen, in comparison with figures from United Kingdom. The common major disorders seen were hypertension, asthma, chronic rheumatic disorders and diabetes. Circulatory disorders were remarkably rare, accounting for only 1% of illnesses. Psychological disorders, both major and minor, were also rarely seen, accounting for only 1% of illnesses which is in marked contrast with figures from the United Kingdom. Factors contributing to these notable findings are discussed.
Tribute
Authors: M K Watterson
Journal: JAMA (1998)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Situs Inversus Totalis in Newly Diagnosed Lymphoma
Authors: Marcus Trautner, Teresa Szyszko, Gopinath Gnanasegaran, Thomas Nunan
Journal: Clinical Nuclear Medicine (2009)

A 65-year-old man underwent a 18F-FDG positron emission tomography/computed tomography (PET/CT) scan for staging of lymphoma. 18F-FDG PET showed lymphomatous lung deposits and widespread nodal lymphomatous deposits above and below the diaphragm. The configuration of the mediastinum was abnormal. Further, widespread deposits were noted in the presumed liver. However, combined PET/CT allowed diagnosis of situs inversus totalis with splenic lymphomatous infiltration and not liver as initially presumed on the PET only images.
Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells
Authors: B Mitton, H -D Chae, K Hsu, R Dutta, G Aldana-Masangkay, R Ferrari, K Davis, B C Tiu, A Kaul, N Lacayo, G Dahl, F Xie, B X Li, M R Breese, E M Landaw, G Nolan, M Pellegrini, S Romanov, X Xiao, K M Sakamoto
Journal: Leukemia (2016)
"No-commitment week": a feasibility study
Authors: I M Zwerling, H R Conte, R Plutchik, T B Karasu
Journal: American Journal of Psychiatry (1978)

To determine the extent to which involuntary hospitalization is overused, a "No-Commitment Week" was set aside, during which emergency room psychiatrists committed only patients in absolute need of hospitalization. Compared with the week before and the week after, there was no significant difference in the number of patients committed during No-Commitment Week. The authors propose replication of the study on a larger scale but suggest that decisions about involuntary hospitalization in public mental hospitals are the result of societal attitudes, which will be subject to change as long as society itself continues to change.
Abstract PR15: Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism
Authors: Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan Shamji, Stuart Schreiber, Stuart Schreiber, Nevan J. Krogan, Kevan M. Shokat, Kevan M. Shokat, Frank McCormick, Daniel Nomura, Sourav Bandyopadhyay, Andrei Goga
Journal: Cancer Research (2015)

Abstract There is an urgent need in oncology to link molecular aberrations in tumors with altered cellular behaviors, such as metabolic derangements, and to identify novel therapeutics for cancer treatment. We have sought to identify synthetic-lethal genetic interactions that cancer cells acquire in the presence of specific mutations. Using engineered isogenic cells, we generated an unbiased and quantitative chemical-genetic interaction map that measures the influence of 51 aberrant cancer genes on 90 drug responses. The dataset strongly predicts drug responses found in cancer cell line collections, indicating that isogenic cells can model more complex cellular contexts. Applied to triple-negative breast cancer, we report clinically actionable interactions with the MYC oncogene including resistance to PI3K/AKT pathway inhibitors and an unexpected sensitivity to dasatinib through LYN inhibition in a synthetic-lethal manner. These studies provide new drug and biomarker pairs for clinical investigation. We have also performed global metabolomics analysis in a subset of the isogenic cell lines demonstrating alterations in metabolic pathways that are shared across multiple oncogenes, as well as those that are distinct to specific oncogenic drivers. This scalable approach enables the prediction of drug responses from patient data and can be used to accelerate the development of new genotype-directed therapies. Citation Format: Maria M. Martins, Alicia Y. Zhou, Alexandra Corella, Dai Horiuchi, Christina Yau, Taha Rakshandehroo, John D. Gordan, Rebecca S. Levin, Jeff Johnson, John Jascur, Mike Shales, Antonio Sorrentino, Jaime Cheah, Paul A. Clemons, Alykhan Shamji, Stuart Schreiber, Stuart Schreiber, Nevan J. Krogan, Kevan M. Shokat, Kevan M. Shokat, Frank McCormick, Daniel Nomura, Sourav Bandyopadhyay, Andrei Goga. Functional analysis of diverse oncogenic driver mutations using an isogenic cell line library identifies novel drug responses and alterations in metabolism. [abstract]. In: Proceedings of the AACR Special Conference on Translation of the Cancer Genome; Feb 7-9, 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 1):Abstract nr PR15.
Phase I trial of intramuscular estradiol valerate (I/M-E) in hormone refractory prostate cancer
Authors: M. Kohli, M. A. Alikhan, H. J. Spencer, G. Carter
Journal: Journal of Clinical Oncology (2004)

4726 Introduction. We evaluated the safety of I/M–E depots administered every two weeks, in hormone refractory prostate cancer patients receiving chemotherapy. Due to high incidence of thrombo-embolic (TE) events associated with oral estrogens, sensitive markers of coagulation activation were monitored during I/M–E treatments to guide initiation of anticoagulant prophylaxis. The primary goal was to establish maximal tolerated dose (MTD) using 3 I/M–E doses (10mg, 20mg and 40 mg). Methods: Patients with no history of TE events were enrolled after consenting and screening for thrombosis. Treatment was delivered in cohorts of three, at the 3 dose levels. Three doses of I/M–E depots were given every two weeks. Prior to each dose, markers of coagulation activation were measured. These included thrombin anti-thrombin complex (TAT; reference range:1.0–4.1μ/l) and quantitative DDimers (QDD; range:0–250ng/ml). Patients with levels above reference ranges were also given daily prophylaxis with 60mg of LMWH. Dose limiting toxicity was defined as two consecutive dosing periods during which TAT/QDD levels remained elevated despite LMWH prophylaxis. Results: 9 patients have completed study on three dose levels (3 each). Study treatment durations varied between 6 and 8 weeks for each patient. All patients received variable duration of prophylaxis with LMWH due to increase in baseline TAT/QDD levels after receiving study drug. No study related TE/hemorrhagic event is seen. Grade 2 toxicities include gynacomastia (1/9), fluid retention (4/9) and local bruises at LMWH injection site (4/9). Anti–Xa activity in patients receiving prophylactic LMWH varied between 0.0–0.4U/ml. Conclusions: MTD is reached at 40mg of I/M–E with prophylactic LMWH in this patient population and is found safe and well tolerated. Where-as oral estramustine and estrogens share a high incidence of TE events, IM–E/LMWH combination appears a safe alternative in advanced prostate cancer. Efficacy trials will be conducted of this combination in prostate cancer patients on chemotherapy. Potential anti cancer effects of LMWH in advanced prostate cancer will also be explored in these future trials. No significant financial relationships to disclose.
P1002 : The histological severity of NAFLD determines the cardiovascular risk and insulin resistance in metabolically healthy and unhealthy overweight individuals
Authors: R. Pais, J. Aron Wisniewsky, F. Nascimbeni, J. Tordjman, P. Lebray, F. Charlotte, P. Bedossa, T. Poynard, K. Clement, V. Ratziu
Journal: Journal of Hepatology (2015)
Abstract P5-02-07: Effect of multidisciplinary case conferences on physician decision making: Breast diagnostic rounds
Authors: T Foster, A Bouchard-Fortier, I Olivotto, ML Quan
Journal: Cancer Research (2016)

Abstract Background: Participation in multidisciplinary case conferences (MCCs) continues to be highly variable, in spite of proven benefits. One contention is the lack of perceived utility on patient management. Purpose: To evaluate the utility of MCCs on physician decision making in benign and malignant breast disease management. Methods: At the Foothills Medical Centre, diagnostic breast MCCs occur biweekly. Patients with interesting or challenging diagnostic or management issues were discussed by attending surgeons, radiologists, pathologists, nurse coordinators and oncologists. Prior to case discussion, the presenting physician was asked to specify his/her management plan. Their response was recorded and compared to the management plan consensus after the MCC discussion. For each case a clinical summary and question was provided by the presenting physician, followed by a review of diagnostic images and/or pathology. After group discussion, a management consensus was achieved and documented. A management change was defined as a difference compared to the pre-MCC plan or if there was no definite management plan prior to MCC. Results: From November 5th, 2014 to May 6th, 2015, 52 patients were discussed in 11 MCCs (1 to 8 patients per MCC). No MCCs were cancelled due to insufficient patients. Of these, 23 (44%) had a change in the management plan compared to the pre-MCC intent including 7 cases where there was no clear plan prior to MCC. Among the 23 cases with a management change, 12 (52%) were due to new or clarified information from radiology review, 6 (26%) were due to new or clarified details from pathology review and 5 (22%) changes occurred from both radiology and pathology review. All cases presented resulted in a consensus management recommendation. Conclusion: The MCCs had a substantial impact on physician decision making. Nearly half of cases presented resulted in a change in clinical recommendation, the majority of which were based on new/clarified diagnostic imaging or pathology information. Presentation of cases at MCCs should be encouraged given their clinical impact on patient care, especially for challenging diagnostic or management issues. Citation Format: Foster T, Bouchard-Fortier A, Olivotto I, Quan ML. Effect of multidisciplinary case conferences on physician decision making: Breast diagnostic rounds. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-02-07.
Abstract B1-21: Network analysis implicates Panx3 as an adipocyte associated factor important during carcinogenesis
Authors: Kyle D. Halliwill, David Quigley, Douglas Chin, Phuong Thuy Le, Reyno Del Rosario, Allan Balmain
Journal: Cancer Research (2015)

Abstract Recent studies exploring risk factors for cancer have unveiled a clear association between body mass index (BMI) and tumor development. However, the mechanistic details of this relationship remain obscure, in large part because of the complexity inherent to these two traits. In order to better understand this relationship, we have undertaken an investigation aimed at identifying genetic elements that influence both BMI and tumorigenesis in a carcinogen-driven mouse model of non-melanoma skin cancer. Using gene expression correlation network analysis we have identified a novel factor associated with both tumorigenesis and BMI, pannexin 3 (Panx3). Our investigation has placed Panx3 as a pivotal regulator of adipocyte signaling, with a clear association with tumorigenesis, suggesting it may play a major role in linking these phenotypes. Further research aimed at elucidating the role Panx3 plays during tumorigenesis, and how it influences adipocyte development and signaling, will be critical to our understanding of the relationship between these two traits. Citation Format: Kyle D. Halliwill, David Quigley, Douglas Chin, Phuong Thuy Le, Reyno Del Rosario, Allan Balmain. Network analysis implicates Panx3 as an adipocyte associated factor important during carcinogenesis. [abstract]. In: Proceedings of the AACR Special Conference on Computational and Systems Biology of Cancer; Feb 8-11 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 2):Abstract nr B1-21.
Anti‐GAPDH Autoantibodies as a Pathogenic Determinant and Potential Biomarker of Neuropsychiatric Diseases
Authors: Federica Delunardo, Denise Soldati, Veronica Bellisario, Alessandra Berry, Serena Camerini, Marco Crescenzi, Cristiano Alessandri, Fabrizio Conti, Fulvia Ceccarelli, Ada Francia, Guido Valesini, Francesca Cirulli, Alberto Siracusano, Alessandra Siracusano, Cinzia Niolu, Ivo Alex Rubino, Elena Ortona, Paola Margutti
Journal: Arthritis & Rheumatology (2016)

Objective To investigate the potential role of circulating autoantibodies specific to neuronal cell surface antigens in the pathophysiology of neuropsychiatric disorders. Methods Two different kinds of immunoscreening approaches were used to identify autoantigens associated with neuropsychiatric disorders in the serum of patients with schizophrenia. The presence of autoantibodies specific to the identified autoantigens was then tested in patients with various psychiatric disorders and in patients with systemic lupus erythematosus (SLE) and concomitant neuropsychiatric manifestations. Furthermore, the potential pathogenic role of these autoantibodies was assessed both in vitro and in vivo. Results GAPDH was identified as a novel autoantigen associated with neuropsychiatric disorders. Serum anti‐GAPDH IgG was detected in the serum of 51% of patients with schizophrenia and 50% of patients with major depression. Moreover, SLE patients with comorbid psychiatric manifestations presented significantly higher serum levels of anti‐GAPDH antibodies than did SLE patients without psychiatric manifestations ( P = 0.004 by chi‐square test). Of note, a significant positive correlation (R = 0.48, P = 0.0049, by Spearman's rank correlation test) was found between the levels of serum anti‐GAPDH antibodies and cognitive dysfunction in patients with SLE. In vitro analysis of the effects of purified human anti‐GAPDH autoantibodies on SH‐SY5Y cells showed an immediate neurite retraction. Finally, in vivo administration of anti‐GAPDH autoantibodies in the right cerebral ventricle of C57BL/6J mice resulted in specific behavioral changes associated with a detrimental cognitive and emotional profile. Conclusion Overall, these data suggest that anti‐GAPDH autoantibodies play a role in the pathogenesis of neuropsychiatric disorders, thus representing a potentially promising tool for the screening of individual vulnerability to these disabling conditions.