tbuckley/cabot-search huggingface dataset:
Abstract 1486: CD127 is Required for Macrophage and Regulatory T Cell Function and Has a Protective Role in Atherosclerosis
Authors: Eva J Van Wanrooij, Gijs van Puijvelde, Hester Happe, Paula de Vos, Theo van Berkel, Johan Kuiper
Journal: Circulation (2006)

CD127 is the receptor for interleukin 7 (IL-7) and is expressed on immature B cells, activated T cells, macrophages and vascular endothelial cells. IL-7 induces Th1 cell activation via CD127, and is essential for the survival of regulatory T cells. Furthermore, premature B cells need IL-7 to proliferate into mature B cells. In LDLr −/−  mice CD127 mRNA was upregulated 5-fold (p Salmonella typhimurium  transformed with pcDNA3.1-CD127. The vaccination resulted in a CD8 mediated cytotoxic response to cells expressing high levels of CD127. Vaccination of LDLr −/−  mice against CD127 aggravated collar induced lesion formation by 267% (p=0.004) with no effects on serum cholesterol levels. Lesions from vaccinated mice showed reduced plaque cellularity (2.8*10 −3  vs. 4.1*10 −3  nuclei/μm 2 , p=0.03) and increased apoptotic area (5.2 *10 3  vs. 1.2*10 3  TUNEL area/intima, p=0.05) compared to control vaccinated animals. IgG1, IgG2a and IgM antibody titers against oxidized LDL were not altered after vaccination, indicating a normal functional B cell population. However, CD127 expression on B cells in the spleen was significantly decreased by 33% by vaccination (p
Abstract 3996: Identification of DEC1-interacting protein DNAJB6 and its role in esophageal squamous cell carcinoma
Authors: Zhuoyou Yu, Victor Chun Lam Wong, Kwok Wah Chan, Maria Li Lung
Journal: Cancer Research (2012)

Abstract Esophageal squamous cell carcinoma (ESCC) has an especially high incidence in China, with five-year survival rates in Hong Kong being of ∼14%. Previously, a critical region at 9q33-34 was narrowed down and identified to be associated with tumor-suppressive function in ESCC. Within this region, Deleted in Esophageal Cancer 1 (DEC1), was identified to suppress anchorage-independent growth and tumorigenesis. In this study, we searched for DEC1-interacting partners by yeast two-hybrid screening. DNAJ (Hsp40) homologue subfamily B member 6 (DNAJB6) was identified as a DEC1-interacting protein and its interaction was further confirmed by the GST pull-down assay and co-localization studies. A putative DEC1-interacting sequence was mapped to the C-terminal end of DNAJB6 coding sequence. Using a tissue microarray constructed with tissues from Hong Kong, significantly higher survival in distant metastasis-free (M0) patients was found to be associated with higher DNAJB6 nuclear staining. DNAJB6 is down-regulated in 12 out of 14 (85.7%) ESCC cell lines, when compared to expression in an immortalized normal esophageal epithelial cell line. The two isoforms of DNAJB6 have distinct cellular localizations. DNAJB6a is mainly localized to the nucleus, while DNAJB6b shows diffuse staining in both the nucleus and cytoplasm. Through migration/invasion assay, we showed that expressions of both isoforms were inversely associated with migration/invasion ability of ESCC cell lines. These results suggest DNAJB6 plays a role in ESCC migration/invasion and metastasis. This gene may play a critical role in ESCC metastasis in an isoform-specific manner, which will be the focus of future studies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3996. doi:1538-7445.AM2012-3996
EPIDEMIC ENCEPHALITIS
Authors: Edward A. Strecker, Gordon F. Willey
Journal: American Journal of Psychiatry (1925)

Fourteen patients showing the sequels of encephalitis epidemica were treated by the intravenous injection of neutral acriflavine. There was marked improvement in three instances; improvement in seven and slight improvement or none in four. The series is too small and the time which has elapsed since the injections too brief to permit even these moderate conclusions to stand as final. Unfortunately, it was necessary to take the clinical material which offered at the time. Our choice was practically restricted to patients with a parkinsonian syndrome which in one case—a boy of 14, was complicated by a behavior disorder, and in another—a girl of 14, by a psychoneurosis. In other words, we were dealing with well-established pathology of a type indicative of chronicity. See table in the PDF file There were no acute cases* available for the experiment; the period of time intervening between the initial illness and the beginning of treatment averaged about 3 years, 4 months, the shortest being 2 years. We feel that this method of treatment is promising, and it should be tested out in the acute stages of the illness and in recent sequellæ.
Acute obstructive cholangitis caused by an enterolith in a duodenal diverticulum
Authors: T. Nonaka, M. Inamori, T. Kessoku, Y. Ogawa, K. Imajyo, S. Yanagisawa, T. Shiba, T. Sakaguchi, A. Nakajima, S. Maeda, K. Atsukawa, H. Takahashi
Journal: Endoscopy (2010)

Duodenal diverticula are common. While they are usually asymptomatic, several complications have been reported.
Epoetin for Severe Anemia in Hepatoerythropoietic Porphyria
Authors: Jörg H. Horina, Peter Wolf
Journal: New England Journal of Medicine (2000)

To the Editor: Hepatoerythropoietic porphyria is a rare autosomal recessive disorder of heme biosynthesis caused by a deficiency of uroporphyrinogen decarboxylase. Excessive accumulation of photoac...
FRI0457 Uveitis incidence in patients with inflammatory lumbar pain
Authors: I.-R. Cojocaru-Gofita, I. Cojocaru, F. Vreju, A. Musetescu, R. Ciurea, A. Barbulescu, M. Florea, A. Rosu, P. Ciurea
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Spondyloarthritis (SpA) defines a group of interrelated diseases with heterogeneous clinical presentation. Regarding the shared distinguishing features one can mention uveitis as an important extraarticular involvement with a highly suggestive impact on the future evolution of SpA. <h3>Objectives</h3> To investigate the prevalence of uveitis in patients with recent onset of inflammatory lumbar pain (ILP) which can be suggestive for developing SpA and to assess the interrelation of uveitis with other specific features of SpA patients. <h3>Methods</h3> We enrolled 49 patients with a reported onset of ILP within a maximum of 3 months prior to the referral. All patients were assessed in the Rheumatology Department over a 3 year period, between 2009-2012. The subjects were included based on their personal evolution into different disease group, they had a mean age of 46.3±5 years aut of which 36 males and 13 females. Patients were monitored and reevaluated every 3 months during the first year and then every 6 months for the final 2. Positive diagnosis of SpA was based on the established criteria such as: the New York modified criteria for ankylosing spondylitis (AS). Uveitis was defined by an ophthalmologic episode diagnosed as such by an ophthalmologist. Data on the baseline functional status, imaging features, and serologic tests were compared in patients with and without uveitis. Factors associated with the presence of uveitis were identified both through univariate and multivariate statistical analysis (logistic regression) <h3>Results</h3> The prevalence of uveitis at inclusion was 10.2 %. Uveitis was observed after the first episodes of ILP in 40 % of patients. The presence of uveitis was significantly associated (univariate) with pain in the lumbar spine, infection preceding inflammatory disease, a previous positive diagnosis of inflammatory bowel disease (IBD); enthesitis or radiologic evident coxo-femural joint involvement, but we could not certify a relation with the fulfillment of specific classification criteria, HLA-B27, Bath Ankylosing Spondylitis Disease Activity Index or the Bath Ankylosing Spondylitis Functional Index. Stastical multivariate analysis showed a positive association between uveitis and pain in the lumbar spine, infection preceding inflammatory disease, a previous diagnosis of IBD (P &lt; 0.05). <h3>Conclusions</h3> Our study showed association of ILP with the onset of IBD and infectious episodes which suggests an important role of environmental factors in the incidence of uveitis in SpA. These data stand the ground for a more thorough approach of the patient whom presents with an uveitis episode since they might already be eligible for the inclusion in a SpA category and evaluated accordingly. <h3>Disclosure of Interest</h3> None Declared
O3.06 * THE EFFECT OF ACETYL-L-CARNITINE IN REDUCING THE TAXANES INDUCED NEUROPATHY
Authors: M. A. Ellithy, R. R. Ghali, W. R. Elghamry, S. Eltaeb, l. M. El wakeel, K. Elhoseiny
Journal: Neuro-Oncology (2014)

Design Prospective randomized controlled open-label pilot study. INTRODUCTION: Paclitaxel is one of the most commonly used chemotherapeutic agents in breast cancer. Studies showed that about 70- 80% of breast cancer patients treated with paclitaxel had persistent neuropathic symptoms at 2 years. The neurotoxicity-related symptoms might result in severe limitation in daily activity and compromise patient's quality of life. Acetyl L-carnitine (ALC) is the ester acetylated form of carnitine, a well characterized amino acid involved in fatty acid beta-oxidation in mitochondria. Animal studies using ALC have shown that it is useful in the prevention and treatment of chemotherapy induced peripheral neuropathy. The potential role of ALC in PIPN is not well evaluated and needs further investigations. OBJECTIVES: This study aims to evaluate the impact of administering acetyl L-carnitine on the incidence and severity of paclitxel induced peripheral sensory and motor neuropathy in patients with breast cancer. PATIENTS AND METHODS: Forty eligible patients with breast cancer were randomized in a 1:1 ratio to one of 2 groups. Control group (n = 20) received three cycles of paclitaxel 135 mg/m2 alone cycled every 21 days. Test group received same regimen plus 1000 mg of oral ALC 3 times/ day for 8 weeks. At baseline, patients in both groups were assessment by clinical examination, nerve conduction velocity (NCV) and serum nerve growth factor (NGF) estimation. Incidence and severity of sensory and motor neuropathy were assessed after each cycle using the CTAC version 4. RESULTS: At baseline, both groups were comparable in age, sex and total dose. In the first cycle, both groups showed no significant difference in frequency of sensory or motor neuropathy or adverse events occurrence. In the 2nd cycle, test group showed a significantly lower frequency of; sensory neuropathy (10 vs 17, p= 0.018) and motor neuropathy (3 vs 12, p= 0.003) versus control. In the 3rd cycle, test group showed a significantly lower frequency of; sensory neuropathy (6 versus 18, p < 0.001) and motor neuropathy (3 vs 17, pp < 0.001) versus control. The frequency of vomiting was significantly higher in the control group (5 vs 0, p= 0.047) versus test in the 3rd cycle. At baseline, the median NGF levels were significantly lower in test group versus control (1.9 vs 9.5, p < 0.001). At the end of the study the median NGF levels were significantly lower (2.4, p = 0.02) in the control group versus their initial baseline levels. While, the test group median levels were higher than their baseline levels. The delta change in NGF was significantly different between the 2 groups (p < 0.001). The NCV was not significantly different between 2 groups neither at baseline nor at the end. CONCLUSION: ALC administration reduced the frequency of paclitaxel induced motor and sensory peripheral neuropathy, and was accompanied with lesser side effects and an improvement in NGF levels.
SAT0087 Does the season of symptom onset influence the severity of radiographic joint destruction in rheumatoid arthritis?
Authors: D. de Rooy, M. Andersson, R. Knevel, T. Huizinga, B. Svensson, A. van der Helm-van Mil
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Several season-associated environmental factors have been related to the onset of rheumatoid arthritis (RA) and the severity of joint complaints. A recent study on early arthritis demonstrated that onset of arthritis symptoms during Winter or Spring was associated with more radiographic joint damage after one year.(1) <h3>Objectives</h3> To evaluate the influence of the season of symptom onset on long-term radiographic progression. <h3>Methods</h3> 688 RA-patients, included in the Leiden Early Arthritis Clinic (EAC) and 830 RA-patients included in the Swedish BARFOT-study were studied. During a follow-up period of 7 and 5 years, respectively, repeated radiological measurements were performed and scored for joint damage according to the van der Heijde modification of the Sharp method. The majority of these patients were recruited in an era when early aggressive treatment was not yet the standard. Seasons were defined meteorologically, meaning that Winter ranges from December 1-February 28, Spring from March 1 – May 31, Summer from June 1 – August 31, and Autumn from September 1 – November 30. <h3>Results</h3> In both cohorts, the proportion of RA-patients that had their symptom onset in Winter tended to be larger than that for the other seasons. This was significant in the BARFOT-cohort (p=0.005), but not in the Leiden EAC. Nonetheless, the radiological progression rates over time were similar in the four seasonal groups in both cohorts (p=0.29 in the Leiden RA-cohort and p=0.46 in the BARFOT RA-cohort). <h3>Conclusions</h3> In two large inception cohorts, we did not find evidence that meteorologically defined seasons of symptom onset have any relevant influence on the severity of joint damage in RA.Therefore, this study does not support the hypothesis that the severity of joint damage of RA is influenced by season related environmental factors such as infectious pathogens. <h3>References</h3> Mouterde G, Lukas C, Logeart I, Flipo RM, Rincheval N, Daures JP et al. Predictors of radiographic progression in the ESPOIR cohort: the season of first symptoms may influence the short-term outcome in early arthritis. Ann Rheum Dis 2011; 70(7):1251-6. <h3>Disclosure of Interest</h3> None Declared
Abstract 3594: Mutations and DNA adducts induced by diesel exhaust particles.
Authors: Jeffrey A. Ross, Esra Mutlu, Charly King, Sarah H. Warren, David M. DeMarini, M. Ian Gilmour, William P. Linak, Garret B. Nelson
Journal: Cancer Research (2013)

Abstract We performed bioassay-directed fractionation and analyzed the polycyclic aromatic hydrocarbon (PAH) levels of a composite sample of diesel-exhaust particles (C-DEP) generated on site from petroleum diesel with a 30-kW 4-cylinder Deutz BF4M1008 diesel engine connected to an air compressor. C-DEP was generated to be representative of contemporary DEP. We extracted particles with dichloromethane (DCM) and determined the percentage of extractable organic material (EOM), solvent-exchanged extracts into dimethyl sulfoxide, and evaluated them for mutagenicity in Salmonella strains TA100 and TA98 +/- S9. More than 50% of the C-DEP EOM mass eluted in fraction 1, but this fraction was not mutagenic. Fraction 2 contained 6% of the mass of OEM, and had 60% of the TA100+S9 activity, suggestive of PAHs. The 3rd fraction contained 14% of the OEM mass and contributed 60% of the TA98-S9 activity, suggestive of nitroarenes. S9 mediated binding of C-DEP extracts was assessed by 32P-postlabeling analysis. Unfractionated C-DEP EOM was incubated with S9 in the presence of calf thymus DNA. The modified DNA was enzymatically hydrolyzed and then subjected to postlabeling analysis using either butanol extraction or nuclease P1 pre-enrichment. Multiple DNA adducts were produced with chromatographic mobilities consistent with PAH and nitro-PAH adducts. Although previous studies of the mutagenicity and adduct-forming potential of diesel exhaust have been reported, most of those utilized exhaust particles that were generated by older diesel engines that were not representative of contemporary diesel exhaust. Data derived from the C-DEP particles are more relevant to understanding the risks posed by contemporary diesel engines. This study provides further characterization of the biochemical potential for these particles to induce DNA damage and gene mutations, key events in the process of chemical carcinogenesis by diesel exhausts. [This is an abstract of a proposed presentation and does not necessarily reflect the views of the U.S. EPA.] Citation Format: Jeffrey A. Ross, Esra Mutlu, Charly King, Sarah H. Warren, David M. DeMarini, M. Ian Gilmour, William P. Linak, Garret B. Nelson. Mutations and DNA adducts induced by diesel exhaust particles. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3594. doi:10.1158/1538-7445.AM2013-3594
Abstract 466: Bone marrow and cancer cells mutually affect each other
Authors: Atsushi Suetsugu, Mohamed K. Hassanein, Yosuke Osawa, Mashito Nagaki, Shigetoyo Saji, Hisataka Moriwaki, Michael Bouvet, Robert M. Hoffman
Journal: Cancer Research (2011)

Abstract Kaplan et al (Nature 438, 820-827, 2005) demonstrated that bone marrow cells can home to tumor-specific pre-metastatic sites thereby providing a permissive niche for incoming metastatic cells. In the present study, bone marrow cells, which were harvested from tumor-bearing mice, were able to form a strong niche compared to bone marrow cells which were harvested from non-tumor-bearing mouse upon co-implantation with cancer cells. When GFP-bone marrow cells from non-tumor-bearing mice, RFP-bone marrow cells from tumor-bearing mice and dual color MMT mouse breast cancer cells expressing GFP in the nucleus and RFP in the cytoplasm were co-transplanted in the spleen of nude mice, much more RFP-bone marrow cells were observed in liver metastases formed by the breast cancer cells compared to GFP-bone marrow cells. Thus bone marrow derived from tumor bearing animals appeared to play a role in metastasis formation compared to bone marrow derived from naïve animals. The results suggest that bone marrow and cancer cells mutually affect each other. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 466. doi:10.1158/1538-7445.AM2011-466
ASSESSMENT OF REGIONAL MYOCARDIAL STRAIN USING TWO DIMENSIONAL SPECKLE TRACKING TRANSTHORACIC ECHOCARDIOGRAPHY TO DISTINGUISH CARDIAC FOCAL FIBROTIC AND NON-FIBROTIC LESIONS CONFIRMED ON CARDIAC MAGNETIC RESONANCE IN HCM
Authors: Koya Ozawa, Nobusada Funabashi, Hiroyuki Takaoka, Michiko Daimon, Yoshio Kobayashi
Journal: Journal of the American College of Cardiology (2015)
BIVENTRICULAR REMODELING BY THREE DIMENSIONAL ECHOCARDIOGRAPHY IS ASSOCIATED WITH OUTCOME IN PATIENTS WITH PULMONARY HYPERTENSION
Authors: Akiko Goda, Keiko Ryo, Antonia Delgado-Montero, Bhupendar Tayal, Marc Simon, Michael Mathier, John Gorcsan
Journal: Journal of the American College of Cardiology (2015)
Ga-67 Scintigraphy in a Patient With B-Cell Lymphoma
Authors: CHRISTIAN WALDHERR, ANDREAS OTTE, JAN MUELLER-BRAND
Journal: Clinical Nuclear Medicine (2000)

In contrast to radiographic imaging, which is limited to regional evaluation, whole-body tumor imaging by Ga-67 scintigraphy is valuable for staging lymphomas. This is a report of whole-body Ga-67 scintigraphy and thoracic radiographs in the follow-up of a patient with histologically confirmed malignant mediastinal non-Hodgkin’s B-cell lymphoma (Ø: 7 cm) without extramediastinal metastases before and after four cycles of CHOP chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone). It shows that Ga-67 scintiscans alone or in combination with other imaging studies have a high diagnostic predictive value in malignant lymphomas.
Stat Bite Breast cancer Incidence, 1973-1989
Authors: B. F. Hankey
Journal: JNCI Journal of the National Cancer Institute (1992)

Journal Article Stat Bite Breast cancer Incidence, 1973–1989 Get access Benjamin F. Hankey, Sc.D. Benjamin F. Hankey, Sc.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 84, Issue 19, 7 October 1992, Page 1467, https://doi.org/10.1093/jnci/84.19.1467 Published: 07 October 1992
AB0549 Comparison between hla b27 prevalence among arabs and some european and american populations
Authors: M. Merashli, I. Uthman, A. Jawad
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> HLA-B27 antigen is the strongest genetic risk factor associated with ankylosing spondylitis (AS<b>)</b> contributing to around thirty percent of its total genetic risk factors. HLA-B27 inclusion into the new ASAS classification criteria for spondyloarthropathies has led to earlier detection of the disease especially for the Arab populations where the diagnosis is often delayed. Data about HLA-B27 prevalence among these populations are very limited. Some data suggest that they had a much lower prevalence of HLA B27 among both healthy and AS patients when compared to Western populations. <h3>Objectives</h3> To Assess HLA-B27 prevalence among healthy and AS patients of the Arab populations and to compare it with some large studies done among European and American populations. <h3>Methods</h3> We divided Arab populations into three parts: A) Levant which includes Jordan, Iraq, Syria, Lebanon, and Palestine, B) Arabian Peninsula which includes Saudi Arabia, UAE, Kuwait, Qatar, Oman, Yemen and Bahrain, and C) North Africa which includes Egypt, Libya, Algeria, Tunis and Morocco. We looked up all the articles from PubMed and Medline addressing HLA-B27 prevalence among all these areas on AS patients and healthy individuals. HLA typing was performed by standard 2-stage micro-lymphocytotoxicity method in most of the studies. We also searched for large studies conducted on Western populations over the last ten years for comparison. <h3>Results</h3> Six studies were conducted in the Levant area, eight in the Arabian Peninsula and ten in North Africa. The prevalence of HLA B27 over these three regions was found to be highly variable ranging between 26.3 and 94% among AS patients and 0.3 to 5.7% among healthy individuals. Studies over some European and American populations revealed also highly variable results, but the number of subjects was much larger. <h3>Conclusions</h3> We have huge lack of data among Arabs in different regions in comparison to Europe and America. The studies conducted are few with small number of subjects. No data was found related to Libya, Yemen or Sudan. The total number of AS patients over 21 studies was found to be 1,535 only. Conclusions regarding HLA B27 prevalence among Arab subjects whether healthy or having AS cannot be drawn. More wide based population studies are needed to prevent delays in diagnosis and to start the treatment earlier for better disease outcome. <h3>Disclosure of Interest</h3> None Declared