tbuckley/cabot-search huggingface dataset:
Buspirone augmentation of fluoxetine in obsessive-compulsive disorder
Authors: P J Markovitz, S J Stagno, J R Calabrese
Journal: American Journal of Psychiatry (1990)

Eleven obsessive-compulsive patients underwent a prospective open-label trial of fluoxetine monotherapy followed by buspirone augmentation. The combination therapy was statistically superior to fluoxetine monotherapy. The results point to the importance of the 5-HT1a receptor in obsessive-compulsive disorder.
Attitudes of psychiatric residents toward the necessity of internship
Authors: T B Karasu, S P Stein, E S Charles
Journal: American Journal of Psychiatry (1975)

The authors note that the elimination of the internship requirement for board certification has engendered much discussion and has called attention to the need for further study of training in psychiatry. To help clarify the issue, they investigated demographic and career choice factors, individual internship decisions, and perceptions and feelings about these decisions in 57 psychiatric residents. The results indicate that the career plans of students have a strong influence on their training choices--those who are oriented toward inpatient psychiatry and psychosomatic medicine view the internship as more relevant than those who plan to concentrate in other areas. The authors suggest further research on the relation between career choice and training preferences.
Replication of "Prediction of antidepressant response to lithium": problems in generalizing to a clinical setting
Authors: D R Campbell, R R Kimball
Journal: American Journal of Psychiatry (1984)

In another study, a simple procedure accurately predicting antidepressant response to lithium was developed in an experimental research setting. The present study failed to replicate these predictors in a clinical setting. The authors suggest using caution in applying these predictors.
SEROTONIN AND CEREBRAL CIRCULATION
Authors: M SPARBERG, J B KIRSNER
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Magnetic Resonance Imaging
Authors: Robert R Edelman, Steven Warach
Journal: New England Journal of Medicine (1993)

Magnetic resonance imaging (MRI) has become an essential tool for the diagnosis of central nervous system disorders and is used increasingly for the evaluation of a variety of diseases in other organ systems. The interpretation of magnetic resonance images is complex. In this time of cost containment in medicine, its high cost necessitates extra care in selecting appropriate clinical indications. In this article we shall review the basic principles, major clinical applications, and cost-benefit considerations in this rapidly changing field as well as upcoming developments.Physical PrinciplesMRI, or nuclear MRI, has its roots in the pioneering work of Bloch, . . .
Early Bone Marrow Examination, On The Fifth Day Of Induction For AML, Is Highly Predictive Of Response
Authors: Yishai Ofran, Michal Hayun, Ronit Leiba, Tsila Zuckerman, Netanel Horowitz, Ron Hoffman, Noam Benyamini, Elinor Sabag, Adi Klil, Alaa Khatib, Noa Lavi, Israel Henig, Benjamin Brenner, Moshe E. Gatt, Ilana Hellmann, Ariela Arad, Shlomo Bulvik, Sharon Gino-Moor, Chezi Ganzel, Revital Saban, Ariella Tvito, Jacob M. Rowe
Journal: Blood (2013)
Symptomatic accessory cardiac bronchus in an infant
Authors: A Fina, M Baqué-Juston, M Guesmi, M Albertini, L Giovannini-Chami
Journal: Thorax (2016)

A 13-month-old infant was referred for evaluation of a severe, therapy-resistant asthma. He presented with daily wheezing, recurrent acute exacerbations, chronic dry-to-wet cough and failure to thrive. His mother had severe allergic asthma with recent admission to the intensive care unit. Initial chest X-rays were normal and skin prick tests were negative. It was decided to undertake a comprehensive work-up to exclude differential diagnoses. Paediatric radiologists initially interpreted the chest CT scan as normal. Bronchoscopic examination revealed an accessory cardiac bronchus (ACB) originating from the medial wall of the intermediate bronchus and filled with purulent secretions (108 Haemophilus influenzae and 108 Moraxella catarrhalis on bronchoalveolar lavage). The lesion was observed on re-examination of the CT scan (figure 1A, B) and demonstrated using three-dimensional (3D) virtual bronchoscopy and surface-rendered reconstructions (figure …
The functions of experimental participatory experiences in the learning- teaching process
Authors: R E Cohen
Journal: American Journal of Psychiatry (1978)

The author analyzes the process by which experimental approaches and observations are transformed into usable knowledge. She examines her past work within this framework. Flexibility and open-ended beliefs permit the testing of new, unfamiliar data against known theoretical backgrounds and their subsequent organization and incorporation into further learning experiences. This material, in turn, can be formulated into new content that enhances one's learning and teaching potentials.
Extensive Methylation of Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 (Efemp1) Promoter Could Predict Malignant Formation in Intraductal Papillary Mucinous Neoplasms (Ipmn)
Authors: K. Yoshida, T. Nagasaka, Y. Umeda, N. Yokomichi, Y. Mori, Y. Takehara, K. Takehara, T. Kawai, F. Tomokazu, F. Taniguchi, T. Yagi, A. Goel, T. Fujiwara
Journal: Annals of Oncology (2014)
Case 32-1985
Authors: Richard C. Cabot, Robert E. Scully, Eugene J. Mark, Betty U. McNeely, Lynne Reid, Eugene J. Mark
Journal: New England Journal of Medicine (1985)

Presentation of CaseA 35-year-old woman was admitted to the hospital because of repeated bouts of pneumothorax, hemoptysis, and hemothorax.She was well until 17 months earlier, when a spontaneous left hemothorax developed. She entered another hospital, where a thoracotomy showed a cyst loosely attached to the posterior basal segment of the left lower lobe; small vessels were observed to course from the lesion into the mediastinum in the region of the inferior pulmonary ligament. Part of the cyst wall was resected together with portions of the walls of two smaller cysts in the left lower and upper lobes. Microscopical . . .
Abstract P1-09-03: Socioeconomic characteristics of African American women with breast cancer
Authors: A Winter, P Raska, M Ornstein, H Moore, A Montero, GT Budd, K Tullio, J Bailey, J Abraham
Journal: Cancer Research (2016)

Abstract Background: Breast cancer is the most common cancer among African American (AA) women. Despite having a lower incidence of breast cancer compared to white women (124.4 compared to 127.9 per 100,000), AAs have a higher death rate (30.2 compared to 21.3 per 100,000). One explanation for this discrepancy is that breast cancer in AAs is often detected at a later stage compared to white women. We conducted this retrospective study to examine socioeconomic characteristics among AA women with breast cancer to see if there were factors associated with stage of diagnosis which may contribute to the known disparities. Methods: We identified all AA women diagnosed with any stage breast cancer from 2006-2014 within the Cleveland Clinic Cancer Data Warehouse and classified them into either early or late stage disease at time of diagnosis. Stages 0-II were classified as early and stages III-IV as late. We examined several variables at diagnosis including age, marital status, tobacco use, alcohol use, Medicaid insurance status, and breast cancer subtype which included HER-2 positive (HER+), hormone receptor positive/HER2 negative (HR+/HER-), and triple negative(TN). AA median income was obtained from US census data according to the zip code at diagnosis. We conducted univariate logistic regression for individual estimates and confidence intervals and multiple logistic regression and model selection to determine significant predictors of stage of diagnosis. Results: Of the 771 AA women identified, 108 (14%) were diagnosed at a late stage of disease with a median age of 59 years. Receptor status distribution was 12.4%, 31%, and 16.6% for HER+, HR+/HER-, and TN respectively for early stage, and 15.7%, 27%, and 25% for late stage. Among early stage 50% were current or previous smokers and 2.6% had Medicaid insurance compared to late stage patients where 63% were current or previous smokers and 9.2% had Medicaid insurance. Multiplicative effect estimates and 95% confidence intervals from univariate logistic regressions identified the following significant factors: tobacco use 1.48 [1.11-1.96] and Medicaid 3.73 [1.56-8.51] (p-values&amp;lt;0.01), and TNBC 1.67 [1.02-2.68] (p-value&amp;lt;0.05). In a stepwise model selection, only tobacco use and Medicaid were retained in the model, as well as age at diagnosis. Conclusions: There are socioeconomic differences among AA women with breast cancer. Only tobacco use, Medicaid insurance, and age at diagnosis were predictive of late stage in this study. Citation Format: Winter A, Raska P, Ornstein M, Moore H, Montero A, Budd GT, Tullio K, Bailey J, Abraham J. Socioeconomic characteristics of African American women with breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P1-09-03.
A Manual of Operative Surgery.
Journal: JAMA (1910)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract MP21: Consumption of Nuts and Beans and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes Mellitus: A Systematic Review and Meta-analysis
Authors: Ashkan Afshin, Renata Micha, Shahab Khatibzadeh, Dariush Mozaffarian
Journal: Circulation (2013)

BACKGROUND  Higher consumption of nuts is linked to lower risk of CHD, but relationships with stroke or diabetes are less established. Further, whether consuming beans (legumes) is associated with CHD, stroke, or diabetes has not been systematically reviewed.   OBJECTIVE  To systematically investigate and quantify the relationships of nut and bean intake with incident CHD, stroke, and diabetes.   METHODS  Using MOOSE and PRISMA guidelines, we systematically searched multiple databases to identify randomized control trials or observational studies examining associations of nut or bean intake with incident CHD, stroke, or diabetes. Studies were excluded if reporting only intermediate physiologic measures, soft CVD outcomes (e.g., angina), or crude risk estimates. Data were extracted independently and in duplicate. Generalized least-squares trend estimation was used to assess dose-response relationships. Pooled summary estimates were calculated by fixed (I2   RESULTS  From 2,737 identified abstracts, 24 observational studies and 0 trials met inclusion criteria, comprising 813,590 individuals and 21,149 CHD, 8,531 stroke, and 24,044 diabetes cases. Nut intake was inversely associated with fatal CHD (n=4 studies, 2,794 cases; RR per 1oz/wk: 0.88; 95% CI 0.83, 0.93; I2 0%), non-fatal CHD (n=3, 4,280 cases; RR per 1oz/wk: 0.94; 95% CI 0.89, 0.98; I2 14%), and diabetes (n=4, 16,371 cases; RR per 1oz/wk: 0.94; 95% CI 0.89, 0.99; I2 61%); but not ischemic or hemorrhagic stroke (n=2, 4,553 cases). Bean intake was also inversely associated with total CHD (n= 4, 10,164 cases; RR 1oz/day: 0.94; 95% CI 0.89, 0.98; I2 6%) but not diabetes (n=2; 5561 cases) or stroke (n=2; 2356 cases). Meta-regression identified age (p 0.04) and study duration (p 0.01) as sources of heterogeneity, with less benefits in older individuals or with greater length of follow-up. Evidence for publication bias was not seen.   CONCLUSIONS  Our findings support benefits of eating nuts and beans to reduce CHD, and nuts to reduce diabetes. More evidence from long-term prospective studies and trials is needed to assess whether eating nuts or beans influences stroke and whether eating beans influences diabetes.
Monoclonal Lym-1 antibody-dependent lysis of B-lymphoblastoid tumor targets by human complement and cytokinine-exposed mononuclear and neutrophilic polymorphonuclear leukocytes
Authors: L Ottonello, P Morone, P Dapino, F Dallegri
Journal: Blood (1996)

Lym-1 is a murine IgG2a monoclonal antibody that recognizes a polymorphic variant of HLA-DR antigens on malignant B cells, with minimal cross-reactivity with normal tissues. Because it can be safely administered in vivo, a detailed knowledge of its ability to recruit and trigger the antitumor immune effector systems is required to optimize potential serotherapeutic approaches in B-lymphoma patients. By using Raji cells as a model of B-lymphoma targets, we found that Lym- 1 activates complement-mediated lysis efficiently. Moreover, Lym-1 was capable of triggering the antibody-dependent cellular cytolysis (ADCC) by peripheral blood mononuclear cells (MNCs). On the contrary, it failed to trigger neutrophilic polymorphonuclear leukocyte (PMN)- mediated ADCC activity. In an attempt to enhance Lym-1 ADCC by MNCs and PMNs, nine biologic response modifiers were tested. MNC-mediated Lym-1 ADCC was significantly stimulated by interleukin-2 (IL-2) and unaffected by other mediators, including gamma-interferon (gamma-IFN), tumor necrosis factor a (TNFalpha), and granulocyte-macrophage colony- stimulating factor (GM-CSF). On the other hand, PMN-mediated Lym-1 ADCC was induced or significantly augmented by various cytokines, such as GM- CSF, TNFalpha, and gamma-IFN, and chemotaxins, such as formyl peptides (FMLP), complement fragment C5a, and IL-8. Both MNC- and PMN-mediated ADCC was unaffected by granulocyte colony-stimulating factor (G- CSF) and insulin-like growth factor-1 (IGF-1). Finally, only GM-CSF and TNFalpha augmented the number of PMNs actually engaged in the binding of Raji target cells. The findings presented here, in particular those showing stimulatory activity of biologic response modifiers, may inspire new attempts for developing Lym-1 antibody-based approaches to the therapy of B lymphomas.
Abstract P3-07-22: RS1008805 polymorphism in CYP19A1 gene is related to the efficacy of hormone therapy in early breast cancer
Authors: X Wang, X Shao, Y Zheng, L Shi, Y Huang
Journal: Cancer Research (2016)

Abstract Purpose It has been suggested that genetic polymorphisms in CYP19A1 gene were related to aromatase activity as well as circulating steroid hormone levels in postmenopausal women. Therefore, it is biologically reasonable that CYP19A1 rs1008805 (A/G) polymorphism may be associated with clinical outcome for hormone therapy. Methods Genotyping for CYP19A1 polymorphism rs1008805 was performed on 287 women with HR-positive early breast cancer. Associations were evaluated between CYP19A1 rs1008805 genotypes and disease-free survival (DFS). Results Based on the analysis of the whole cohort, no significant differences were observed between rs1008805 genotypes and DFS, 5-year DFS rate. However, in postmenopausal women, rs1008805 genotypes were significantly associated with DFS and 5-years DFS rate (AA versus AG versus GG: 89.2 months versus 58.2 versus 32.7 months; 55.9% versus 47.8% versus 0%; P = 0.019). In addition, when the population was subgrouped into two cohorts, women carrying GG variant have a poorer DFS, 5-years DFS rate (GG versus AA or AG: 32.7 months versus 70.6 months; 0% versus 52.1%; HR, 3.613; 95% CI,1.380-9.457; P = 0.005). Furthermore, being adjusted by patients features in multivariate analyses, GG genotype remained an independent prognostic factor for DFS (HR, 3.439; 95% CI, 1.251-9.456; P = 0.017). However, there was no significant differences in DFS and 5-years DFS rate between women harbor the minor allele and those with the homozygous common allele (AG or GG versus AA: 52.4 months versus 89.2 months; 41.0% versus 52.9%; HR, 1.288; 95% CI, 0.705-2.353; P = 0.408). In addition, there were no differences between rs1008805 polymorphisms and DFS among premenopausal women. Conclusions The homozygous minor allele (GG) of CYP19A1 rs1008805 is significantly associated with worse clinical outcome of hormone therapy in postmenopausal HR-positive early breast cancer patients. If confirmed, genotyping for CYP19A1 polymorphisms rs1008805 may provide predictive information for better selection of endocrine treatment. Citation Format: Wang X, Shao X, Zheng Y, Shi L, Huang Y. RS1008805 polymorphism in CYP19A1 gene is related to the efficacy of hormone therapy in early breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P3-07-22.
Salmonella Typhimurium outbreaks in the Netherlands in 2008
Authors: Y Doorduyn, A Hofhuis, C  M de Jager, W  K van der Zwaluw, D  W Notermans, W van Pelt
Journal: Eurosurveillance (2008)

A large, countrywide outbreak due to multi-resistant Salmonella Typhimurium phage type DT104 is ongoing in the Netherlands, with 152 cases as of 20 October. Pilot interviews did not suggest any specific source of infection but a hypothesis pointing to pork products has been formulated and a large case-control study is under way. Earlier this year two other oubtreaks due to S. Typhimurium were detected and investigated, the first (DT15A) linked to a particular brand of cream cheese, the other (Dutch phage type ft507) to a local butcher.
Oral Sucrose and Exercise Tolerance in McArdle's Disease
Authors: Jason L Gaglia, Joseph I Wolfsdorf
Journal: New England Journal of Medicine (2004)

1575 inflammatory lung disease, and the antiphospholipid syndrome), markers of oxidative stress may indicate increased lipid peroxidation, which probably contributes to atherosclerosis by providing highly oxidized low-density lipoprotein that is deposited in arterial walls. They have reported increased lipid peroxidation, measured as urinary levels of the isoprostane prostaglandin F 2 a type III and similar products of oxidized prostaglandinrelated molecules. Increased peroxidation is generally viewed as an adverse metabolic state that confers a predisposition to atherosclerosis. In summary, we take the points made that exposing patients to statins may in a very small proportion increase their risk of SLE-like disease and that increased lipid oxidation is likely to play a role in accelerating atherosclerosis in patients with SLE and others with chronic inflammatory or degenerative diseases.
Malaria imported into the United Kingdom in 1996
Authors: D J Bradley, D C Warhurst, M Blaze, V Smith, J Williams
Journal: Eurosurveillance (1998)

Virtually all malaria infections seen in the United Kingdom (UK) in recent years have been contracted overseas and imported into the UK, apart from two cases in 1976 due to imported infected mosquitoes and occasional cases of congenital or of transfusion
The need for tests of normal functioning in the psychiatric interview
Authors: L L Havens
Journal: American Journal of Psychiatry (1984)

Physical medicine has a body of normal findings that make possible the definition of disease states. The routine procedures of psychiatry do not include any such tests of health. As a result, the psychiatric concept of illness has no stable base from which specific conditions can be described. The author suggests two human capacities, connectedness and self-protectiveness, that can be assessed by the psychiatrist in attempting to evaluate the patient's overall psychological health.