tbuckley/cabot-search huggingface dataset:
Green buildings
Authors: Lynn Eaton
Journal: BMJ (2006)

The new wing at Lewisham Hospital looks set to be a shining example of environmentally friendly building. The trust's medical director Robin Stott1 and senior managers were committed to sustainability and wanted to use the most energy efficient methods, incorporate materials that could be recycled at the end of the building's planned 30 year life, and give something back to the local community. It's an indicator of Dr Stott's green credentials that he became rather tetchy when I suggested driving over to see the building site, saying he would prefer me to use public transport.

The new 419 bed block is crammed into the existing hospital site, between the main road and small Ravensbourne river. The seven storey building (eight if you include the plant room on the roof) cleverly follows the curves of the river. There is a small park on the other bank, which would take the bulk of any flood water should the levels ever rise too high. The first floor of the building is about 5 metres above the height of the river, reducing the effect of any potential flooding. The building began in July 2004 and the hospital is due to open in November 2006, at a cost of £58m (€85m, $109m).
Medical Schools in the United States
Journal: JAMA (1989)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Prevalence of Gilles de la Tourette's syndrome in North Dakota adults
Authors: L Burd, J Kerbeshian, M Wikenheiser, W Fisher
Journal: American Journal of Psychiatry (1986)

The authors estimate the prevalence of Tourette's disorder in North Dakota to be .22 per 10,000 for women and .77 per 10,000 for men. Comparison with figures for North Dakota children suggests that the disorder is relatively uncommon in adults.
Mechanical Circulatory Support and Rationale for Future Research
Authors: Francesco Romeo, Domenico Sergi, Maria Cristina Acconcia
Journal: JAMA Internal Medicine (2016)

To the Editor We read with interest an article by Khera et al1 in a recent issue of JAMA Internal Medicine on the trends in use of percutaneous ventricular assist devices in the United States from 2007 to 2012, commented on by Deedwania and Acharya.2
A psychobiological perspective on the personality disorders
Authors: L J Siever, K L Davis
Journal: American Journal of Psychiatry (1991)

A preliminary but growing body of evidence supports the existence of genetic and biological substrates of personality, suggesting the utility of a psychobiological perspective on the personality disorders. The investigation of biological correlates of personality disorders can provide an empirical base to explore the relationship between biological predispositions and psychological function. The authors propose a psychobiological model based on dimensions of cognitive/perceptual organization, impulsivity/aggression, affective instability, and anxiety/inhibition. These dimensions span the DSM-III-R axis I and axis II disorders. The authors review phenomenological, genetic, and biological evidence in relation to each of these dimensions. Although such an approach remains heuristic, this model provides a promising vantage point from which to generate investigation of the development and treatment of the personality disorders.
Facilitating a culture of responsible and effective sharing of cancer genome data
Authors: Lillian L Siu, Mark Lawler, David Haussler, Bartha Maria Knoppers, Jeremy Lewin, Daniel J Vis, Rachel G Liao, Fabrice Andre, Ian Banks, J Carl Barrett, Carlos Caldas, Anamaria Aranha Camargo, Rebecca C Fitzgerald, Mao Mao, John E Mattison, William Pao, William R Sellers, Patrick Sullivan, Bin Tean Teh, Robyn L Ward, Jean Claude ZenKlusen, Charles L Sawyers, Emile E Voest
Journal: Nature Medicine (2016)
Pregnancy Dependence of Mammary Tumors in Strain DDD Mice 2
Authors: Akio Matsuzawa, Tadashi Yamamoto, Kiyoshi Suzuki
Journal: JNCI Journal of the National Cancer Institute (1974)

Of 2411 strain DDD retired breeder mice, under ≈ 12 months of age, from our production colony, mammary tumors developed in 22 (0.91%). These tumors were all transplanted into virgins. Half were force-bred so that the tumors could be examined for pregnancy dependence: 4 were classified as completely pregnancydependent (CPD), 2 as moderately pregnancy-dependent (MPD), 3 as slightly pregnancy-dependent (SPD), and 13 as pregnancy-independent (PID). These CPD tumors did not grow in virgins but grew rapidly in pregnant breeders and regressed after parturition, reaching ascending peaks in successive pregnancies. Morphologically, 4 CPD tumors were type A composed mainly of glandular spaces of various sizes surrounded by a single layer of small, cuboidal epithelial cells and filled with a milky secretion. One MPD tumor was type A similar to the above-mentioned and the other, a pale-cell carcinoma. Two type A + B tumors and 1 type P were SPD. PID tumors consisted of 3 type A + B without secretory activity, 5 type P, 3 pale-cell carcinomas, and 2 mixed tumors. These findings suggest that the mammary tumor virus of strain DDD may belong to plaque-inducing MTV.
Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica
Authors: Yuanyuan Xie, Huiqin Wen, Ke Yan, Shushu Wang, Xuesong Wang, Jian Chen, Yuanling Li, Yuanhong Xu, Zhengrong Zhong, Jilong Shen, Deyong Chu
Journal: Cellular and Molecular Immunology (2016)
Abstract 16187: Validation of Novel Algorithm to Automate Detection of Fractionated Electrograms During Ventricular Tachycardia (VT) Ablation
Authors: Pouria Alipour, Yaariv Khaykin, Meysam Pirbaglou, Paul Ritvo, Gal Hayam, Alfredo Pantano, Simon Kochhaeuser, Jeffrey Healey, Isabelle Nault, Jean-Francois Sarrazin, Marc W Deyell, Atul Verma
Journal: Circulation (2015)

Introduction: Ablation of ventricular tachycardia (VT) substrate in patient at risk for VT in the setting of ischemic heart disease is a technically challenging procedure. We thought to evaluate a novel algorithm used to automatically identify target electrograms. Methods: 16 consecutive patients (70±10 years of age, 90% male, 34±18% LV EF) had 20 ablations for ischemic VT using CARTO 3 mapping system over 2 years. Left ventricular (LV) substrate was mapped during right ventricular (RV) apical stimulation. Navistar Thermocool 3.5 mm irrigated tip catheters were used in all patients. A novel algorithm counting the number of electrogram deflections (NOD) crossing the 0.05mV noise threshold and duration of time from first to last such deflection during the window of interest (total fractionation time, TFT) was applied to all acquired maps after ablation was complete. Snapshots of 200 electrograms representing the high and low end of TFT and NOD values were presented to a group of 8 electrophysiologists experienced in VT ablation who were asked to select electrograms they would target for substrate ablation. The diagnostic accuracy of TFT and NOD values was then analysed. Results: Across the range of TFT values (0.0-281.0 ms), a cut-off value of 49.0 ms (81.6% sensitivity, 57% specificity) was established as an optimal indicator of an ablation target. Area under the curve for TFT was 0.675 (95% CI: 0.59-0.75, p=0.001). For NOD values (0.0-70.0 deflections), a cut off of 4.5 deflections (88.0% Sensitivity, 57 % specificity) was established as an optimal indicator of an ablation target. The area under the curve for NOD yielded an area of 0.75 (95% CI: 0.68-0.82, P=0.001). For TFT-NOD product as a variable, a cut-off value of 64 (91.0% Sensitivity, 52.4 % specificity) an optimal indicator of an ablation target. The Area under the curve for NOD and TFT multiple was 0.72 (95% CI: 0.65-0.80, P=0.001). Conclusion: A novel algorithm may be able to automatically classify LV substrate during mapping and ablation of ischemic VT with high sensitivity and acceptable specificity.
Constitutive Activation of PI3K in Oocyte Induces Ovarian Granulosa Cell Tumors
Authors: So-Youn Kim, Katherine Ebbert, Marilia H. Cordeiro, Megan M. Romero, Kelly A. Whelan, Adrian A. Suarez, Teresa K. Woodruff, Takeshi Kurita
Journal: Cancer Research (2016)

Cell-cell interactions play crucial roles in the maintenance of tissue homeostasis, a loss of which often leads to varying diseases, including cancer. Here, we report that uncontrolled PI3K activity within oocytes irreversibly transforms granulosa cells (GC), causing GC tumors (GCT) through perturbed local cell communication. Previously, we reported reproductive phenotypes of transgenic mice, in which expression of constitutively active mutant PI3K was induced in primordial oocytes by Gdf9-iCre. The transgenic mice (Cre(+)) demonstrated severe ovarian phenotypes, including the overgrowth of excess ovarian follicles and anovulation. Surprisingly, the Cre(+) mice became cachectic by postnatal day 80 due to bilateral GCT. Although GCT cells proliferated independently of oocytes, local interactions with mutant PI3K-positive oocytes during early folliculogenesis were essential for the GC transformation. Growing GCT cells expressed high levels of inhibin βA and nuclear SMAD3, and the proliferation rate was positively correlated with a high activin A to inhibin A ratio. These results suggested that the tumor cells stimulated their growth through an activin A autocrine signaling pathway, a hypothesis confirmed by activin A secretion in cultured GCT cells, which proliferated in response. Although communication between the oocyte and surrounding somatic cells is critical for the normal development of ovarian follicles, perturbations in oocyte-GC communication during early folliculogenesis can induce GCT by activating an autocrine growth circuit program in GC. Cancer Res; 76(13); 3851-61. ©2016 AACR.
Carboplatin hypersensitivity reaction (HSR): Analysis of safety and success of a short outpatient platinum rechallenge protocol (PRP) in epithelial ovarian carcinoma (EOC).
Authors: Los Vincent Newton, Abbey Jebb, Peter C.C. Fong, Michelle Margaret Vaughan, Elaine Sandra Rogers, Kathryn F. Chrystal
Journal: Journal of Clinical Oncology (2014)

5538 Background: Platinum remains mainstay to EOC therapy, in first line and relapse. HSR to Carboplatin(Cb) is well reported and limits utility of further platinum therapy. Reported desensitisation regimes are lengthy, involving inpatient high dependency care. In 2005 our centre developed a standardised rapid 1.5 hour, 3 step outpatient PRP for patients(pts) who had HSR to Cb. We performed a retrospective review of the outcomes and safety of our PRP. Methods: All pts given Cb for stage I - IV EOC from 2005 to 2012 were identified. Data was obtained on baseline characteristics, all therapy, HSR, safety and efficacy of the PRP. HSR severity was graded consistent with published data. Our PRP consists of pre- and post-medication with antihistamine and steroids, a 15 minute infusion of diluted Cb or Cisplatin (Cis), then 15min of undiluted platinum at reduced rate, with the remainder administered thereafter over 1 hour. Results: 406 pts were identified. Median age 60.6 years (range 21-88). 64pts (15.8%) had an HSR to Cb. First HSR occurred at median cycle 8.5 (range 1-24) of Cb exposure. 67% of HSR occurred during second line Cb. 8/64 pts had a moderate-severe HSR to Cb. The incidence of pts having a Cb HSR during second line treatment at PFI of 6-12 months, 12-24 months and >24 months was 44%, 36% and 27% respectively. 51/64 pts (79.7%) were retreated with either the Cb PRP (29pts) or Cis PRP (22pts) at clinician discretion. 14/29 pts had a HSR on Cb PRP, 1/22pts on Cis PRP. The Cis PRP was significantly less likely to result in second HSR, OR=0.05 (p=0.006). Second HSR grade was a higher than initial HSR in 4pts but none graded severe. 9/14 pts having second HSR on Cb PRP were subsequently treated with Cis PRP. 7/9 pts had no further HSR. Using our PRP, patients received a median of 4 further cycles of platinum on the PRP (range 1-11). There were no deaths from HSR in our cohort Conclusions: Our rapid outpatient PRP is safe and allowed a significant proportion of patients to continue further platinum chemotherapy. Treatment with Cis PRP has significantly fewer reactions than Cb PRP and should be considered the preferred platinum for rechallenge in suitable patients.
Modification of Photocarcinogenesis by Chemical Agents&lt;xref ref-type="fn" rid="FN1"&gt;1&lt;/xref&gt;
Authors: Frederick Urbach, M.D., P. Donald Forbes, Ph.D., Ronald E. Davies, Ph.D.
Journal: JNCI Journal of the National Cancer Institute (1982)

The evidence is long standing and compelling that chemical agents can modify the carcinogenic effects of light. Various types of chemical-light interaction are discussed, and events in chemical photocarcinogenesis, chemically enhanced photocarcinogenesis, and promotion of photocarcinogenesis are described. Specific examples of each type of process are given, and the importance of interaction of various wavelengths of UV radiation for these processes is stressed.
Reconsolidation versus retrieval competition: Rival hypotheses to explain memory change in psychotherapy
Authors: Chris R. Brewin
Journal: Behavioral and Brain Sciences (2015)

Abstract I suggest it is premature to assume memory reconsolidation provides a unifying model of psychotherapeutic change given our current state of knowledge, and that other basic memory mechanisms, also supported by neuroscience, have a stronger claim at present. In particular, I propose that retrieval competition provides a more plausible alternative to memory reconsolidation.
A pilot study CD34 selected haploidentical transplant using a chemotherapy-only preparative regimen and intensive antibiotic prophylaxis for treatment of advanced leukemia
Authors: J. L. Gajewski, J. McMannis, E. Shpall, M. de Lima, S. Giralt, R. Jones, I. Khouri, C. Hosing, M. Korbling, R. E. Champlin, M. Donato
Journal: Journal of Clinical Oncology (2007)

7097 Background: We present preliminary data of haploidentical transplant for 13 patients (pts) with acute leukemia. Methods: Phase II Study Results: We present preliminary data of haploidentical transplant for 13 patients (pts) with acute leukemia using a chemotherapy-only preparative regimen of Melphalan 140 mg/m 2 on day −8; Thiotepa 10 mg/kg on day −7; Fludarabine 40 mg/m 2 on days −6, −5, −4, −3; 1.5 mg/kg of rabbit ATG/day days −6, −5, −4, −3. The transplant was administered on day 0 using positive selection of CD34 positive cells by the CliniMACS device as a means of T-cell depletion. All products had &lt;1 × 10 4 CD3+ T-cells/kg recipient body weight and needed a minimum of 5 × 10 6 CD34+ cells/kg but preferably &gt;1 × 10 7 CD34+ cells/kg recipient body weight. Age ranged 23–50 years/median 37 years, four patients were in advanced remission and nine were in refractory relapse. Patients received intensive PCP prophylaxis with sulfamethoxazole-trimethoprim and pentamidine prior to transplant and during pancytopenia; CMV prophylaxis with valganciclovir during the BMT prep and foscarnet while pancytopenic; and with liposomal amphotericin or cancidas for fungal prophylaxis. Two patients had primary graft failure-one survived disease free and one relapsed. One patient died of multiple organ failure prior to engraftment. Median time to engraftment was 15 days (range, 9–26) to 500 neutrophils and 14 days to platelets 20,000 (range, 13–25). Seven patients died of relapse at a median of 10 months (range 2–13 months), and one patient died of a viral infection. Two of 10 patients who engrafted developed grade one acute graft-versus-host (GVHD) and four patients had chronic GVHD (3 limited, 1 extensive). Four patients survive beyond 2 years, without recurrent disease. Conclusions: This report for haploidentical transplant demonstrates that a chemotherapy only preparative regimen can achieve a high rate of engraftment. Infectious complications were minimal with aggressive prophylaxis. Long-term remission are achievable with little risk of severe GVHD with t-cell depletion with use of CliniMACS in haploidentical stem cell transplant. No significant financial relationships to disclose.
Detrimental Effects of Prechemotherapy Filgrastim
Authors: Stefan Serke, Dieter Huhn, Hans Eric Johnsen, Richard Herrmann, Vivianne C.G. Tjan-Heijnen, Bonne Biesma, Jan Festen, Ted A.W. Splinter, Anton Cox, D. J. Theo Wagener, Pieter E. Postmus
Journal: Journal of Clinical Oncology (1999)
Effectiveness of Regional Hyperthermia with Chemotherapy for High-Risk Retroperitoneal and Abdominal Soft-Tissue Sarcoma After Complete Surgical Resection: a Subgroup Analysis of a Randomized Phase-Iii Multicenter Study
Authors: L.H. Lindner, M. Albertsmeier, N. Prix, P. Hohenberger, S. Abdel-Rahman, N. Dieterle, M. Schmidt, U. Mansmann, C. Bruns, K. Jauch, R. Issels, M. Angele
Journal: Annals of Oncology (2014)
Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD–Related Systemic Inflammation
Authors: Kirstin Andersen, Marie Sophie Kesper, Julian A. Marschner, Lukas Konrad, Mi Ryu, Santhosh Kumar VR, Onkar P. Kulkarni, Shrikant R. Mulay, Simone Romoli, Jana Demleitner, Patrick Schiller, Alexander Dietrich, Susanna Müller, Oliver Gross, Hans-Joachim Ruscheweyh, Daniel H. Huson, Bärbel Stecher, Hans-Joachim Anders
Journal: Journal of the American Society of Nephrology (2016)

CKD associates with systemic inflammation, but the underlying cause is unknown. Here, we investigated the involvement of intestinal microbiota. We report that collagen type 4 α3-deficient mice with Alport syndrome-related progressive CKD displayed systemic inflammation, including increased plasma levels of pentraxin-2 and activated antigen-presenting cells, CD4 and CD8 T cells, and Th17- or IFNγ-producing T cells in the spleen as well as regulatory T cell suppression. CKD-related systemic inflammation in these mice associated with intestinal dysbiosis of proteobacterial blooms, translocation of living bacteria across the intestinal barrier into the liver, and increased serum levels of bacterial endotoxin. Uremia did not affect secretory IgA release into the ileum lumen or mucosal leukocyte subsets. To test for causation between dysbiosis and systemic inflammation in CKD, we eradicated facultative anaerobic microbiota with antibiotics. This eradication prevented bacterial translocation, significantly reduced serum endotoxin levels, and fully reversed all markers of systemic inflammation to the level of nonuremic controls. Therefore, we conclude that uremia associates with intestinal dysbiosis, intestinal barrier dysfunction, and bacterial translocation, which trigger the state of persistent systemic inflammation in CKD. Uremic dysbiosis and intestinal barrier dysfunction may be novel therapeutic targets for intervention to suppress CKD-related systemic inflammation and its consequences.
Influence of physical properties of carrier on the performance of dry powder inhalers
Authors: Tingting Peng, Shiqi Lin, Boyi Niu, Xinyi Wang, Ying Huang, Xuejuan Zhang, Ge Li, Xin Pan, Chuanbin Wu
Journal: Acta Pharmaceutica Sinica B (2016)

Dry powder inhalers (DPIs) offer distinct advantages as a means of pulmonary drug delivery and have attracted much attention in the field of pharmaceutical science. DPIs commonly contain micronized drug particles which, because of their cohesiveness and strong propensity to aggregate, have poor aerosolization performance. Thus carriers with a larger particle size are added to address this problem. However, the performance of DPIs is profoundly influenced by the physical properties of the carrier, particularly their particle size, morphology/shape and surface roughness. Because these factors are interdependent, it is difficult to completely understand how they individually influence DPI performance. The purpose of this review is to summarize and illuminate how these factors affect drug–carrier interaction and influence the performance of DPIs.
Modulation of the epithelial-to-mesenchymal-like transition by BMP7 and TGF-β in non-small cell lung cancer cell lines in vitro.
Authors: P. M. Marconi, K. Patel, L. Thimothy, S. Buchanan, M. J. Liptay, J. Coon, P. Bonomi, J. A. Borgia
Journal: Journal of Clinical Oncology (2010)

e21016 Background: Tumor cells that have undergone an epithelial-to-mesenchymal (EMT)-like phenotypic transformation in situ have been implicated in tumor cell invasiveness and disease progression. Stromal-derived cytokines, such as transforming growth factor beta (TGF-β), drive this transformation, yet few reports have defined protein factors that can maintain the epitheliod characteristics of the primary tumor cells or revert cells to an epitheliod phenotype. Bone morphogenetic protein 7 (BMP7) has been shown to mediate this reversion for breast, prostate, and pancreatic cancers. This effect has not been shown in non-small cell lung cancer (NSCLC) though this disease remains the primary cause of cancer- related mortality worldwide. We investigated if NSCLC lines treated with BMP7 or TGF-β demonstrated differences in migration or invasion abilities or expression of varying biomarkers characteristic of EMT transformation such as E-cadherin and N-cadherin. Methods: Experiments were performed in parallel on A549, H358 and 1437 NSCLC cell lines pretreated for 7 days using BMP7 or TGF-β, as well as control groups for comparison. All groups were maintained in RMPI (H358, 1437) or DMEM (A549) high glucose media containing 10% serum. Standard Western blots were performed to determine expression of varying mesenchymal biomarkers. Scratch assays were performed by producing a 200μm scratch and documenting cellular migration in 24-hour intervals over 48 hours. Invasion assays were performed using commercially available Matrigel invasion chambers and invading cells were quantitatively compared. Results: TGF-β-treated cells demonstrated an increased expression of N-cadherin and fibronectin, a faster rate of migration, and a trend toward increased invasiveness. BMP7-treated cells exhibited the opposite phenotypic traits, including decreased expression of mesenchymal biomarkers via Western blots. Conclusions: Our findings suggest the EMT-like transition associated with NSCLC progression is highly plastic and can be modulated with growth factors. These results may have implications in treatment regimens to convert cancer cells to more epithelial-like, less aggressive cancers. No significant financial relationships to disclose.