tbuckley/cabot-search huggingface dataset:
Health Care for Lesbian, Gay, and Bisexual People Comes Out of the Closet
Authors: Mitchell H. Katz
Journal: JAMA Internal Medicine (2016)

Delivering patient-centered care requires an understanding of the psychosocial and behavioral determinants of health.The article by Gonzales et al 1 in this issue of JAMA Internal Medicine demonstrates that one such determinant, sexual orientation, has an influential effect on several aspects of health.Psychological distress was more common among gay men, bisexual men, and bisexual women than heterosexuals.There was more cigarette smoking and greater alcohol use among lesbians, gay men, and bisexuals than heterosexuals.Although this study is not the first to note these differences among lesbians, gay men, and bisexuals, it is the first to capture the disparity in a population-based sample rather than a convenience or clinicbased sample.As Gonzales et al 1 note, the higher psychological distress and use of unhealthy substances likely reflect the experience
Case 15-1968
Authors: S. William Stanbury, Benjamin Castleman
Journal: New England Journal of Medicine (1968)

Presentation of Case First admission. A twenty-six-year-old man entered the hospital because of flank pain.Eight years previously urinalysis had shown proteinuria. He remained well until three months before admission, when nausea, abdominal discomfort and persistent aching in the left flank developed. There had been no weakness, polydipsia, polyuria, nocturia, hematuria, dysuria or episodes suggestive of the passage of renal calculi. For many years he had consumed 2 quarts of milk daily. He denied taking vitamins, phenacetin-containing medications or alkalis. He had been deaf in the left ear for an unknown period.The patient's father, who was alive at the . . .
Squamous-Cell Carcinoma of the Tongue
Authors: Rui P P Albuquerque, Andrea Richards
Journal: New England Journal of Medicine (2016)

A 73-year-old woman presented with a persistent ulcer and white patch on the right margin of the tongue. Intraoral examination revealed a superficial ulcer with a homogeneous base, an indurated upper border, and an adjacent speckled red and white patch at the lower border.
Middle East Respiratory Syndrome: Emergence of a Pathogenic Human Coronavirus
Authors: Anthony R. Fehr, Rudragouda Channappanavar, Stanley Perlman
Journal: Annual Review of Medicine (2016)

In 2012, a zoonotic coronavirus was identified as the causative agent of Middle East respiratory syndrome and was named MERS coronavirus (MERS-CoV). As of August 11, 2016, the virus has infected 1,791 patients, with a mortality rate of 35.6%. Although MERS-CoV generally causes subclinical or mild disease, infection can result in serious outcomes, including acute respiratory distress syndrome and multi-organ failure in patients with comorbidities. The virus is endemic in camels in the Arabian Peninsula and Africa and thus poses a consistent threat of frequent reintroduction into human populations. Disease prevalence will increase substantially if the virus mutates to increase human-to-human transmissibility. No therapeutics or vaccines are approved for MERS; thus, development of novel therapies is needed. Further, since many MERS cases are acquired in healthcare settings, public health measures and scrupulous attention to infection control are required to prevent additional MERS outbreaks.
PD2-2-7: Two wrongs make a right: the use of whole genome amplification for pair-wise genome-wide copy number analysis of limited patient material
Authors: Trevor J. Pugh, Allen D. Delaney, Stephane Flibotte, Noushin Farnoud, Irene Li, Pedro Farinha, Randy D. Gascoyne, Marco A. Marra
Journal: Journal of Thoracic Oncology (2007)
Osler in Jail
Authors: Joseph S. Bell
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High Levels Of IL-27 Occur In Newly Diagnosed Acute Myeloid Leukemia (AML) and May Influence Outcome By Suppressing T Cell Function
Authors: Nicole Stephens, Sawa Ito, Stephen A. Strickland, Bipin N. Savani, Madan Jagasia, J. Joseph Melenhorst, Fang Yin, Nancy F. Hensel, Fariba Chinian, Xingmin Feng, Leigh Samsel, Keyvan Keyvanfar, Christopher S. Hourigan, Minoo Battiwalla, Pawel Muranski, A. John Barrett
Journal: Blood (2013)
Lateral ventricular size and social network differentiation in young, nonchronic schizophrenic patients
Authors: L J Seidman, R L Sokolove, C McElroy, P H Knapp, T Sabin
Journal: American Journal of Psychiatry (1987)

The authors correlated lateral cerebral ventricular size with social network differentiation and social outcome in 15 young, nonchronic patients with schizophrenia and schizophreniform disorder. Patients with fewer social contexts, fewer types of relationships, and less independent residence had larger ventricles.
Phase I Study of a Neutralizing Monoclonal Anti-CTLA4 Antibody (MDX-010) in Patients with Relapse of Malignancy after Allogeneic Hematopoietic Stem Cell Transplantation.
Authors: Asad Bashey, Bridget Medina, Sue Corringham, Mildred Pasek, Ewa Carrier, Howard Streicher, Israel Lowy, James Mason, Robert J. Soiffer, Edward D. Ball
Journal: Blood (2005)
Proposal of a Genetic Classifier for Risk Group Stratification in Pediatric T-Cell Lymphoblastic Lymphoma Reveals Significant Differences to T-Cell Lymphoblastic Leukemia
Authors: Bettina R. Bonn, Martin Zimmermann, Sebastian Balbach, Marius Rohde, Ilske Oschlies, Wolfram Klapper, Olga Makarova, Claudia Rossig, Birgit Burkhardt
Journal: Blood (2014)
Assessing the Safety and Efficacy of Ruxolitinib in a Multicenter, Open-Label, Expanded-Access Study in Japanese Patients with Myelofibrosis (MF)
Authors: Keita Kirito, Norio Komatsu, Kazuya Shimoda, Hikaru Okada, Taro Amagasaki, Toshio Yonezu, Koichi Akashi
Journal: Blood (2015)
Preliminary results from a phase 1/2 study of INCB024360 combined with ipilimumab (ipi) in patients (pts) with melanoma.
Authors: Geoffrey Thomas Gibney, Omid Hamid, Tara C. Gangadhar, Jose Lutzky, Anthony J. Olszanski, Thomas Gajewski, Bartosz Chmielowski, Peter D. Boasberg, Yufan Zhao, Robert Charles Newton, Peggy A Scherle, Jill Bowman, Janet Maleski, Lance Leopold, Jeffrey S. Weber
Journal: Journal of Clinical Oncology (2014)

3010 Background: Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolizing enzyme that is overexpressed in cancers and induces immune tolerance by suppressing T-cell responses. INCB024360, a potent, selective IDO1 inhibitor, was generally well tolerated as monotherapy up to 700 mg BID. Preclinical data support anti-tumor synergy for INCB024360 when administered with antibody antagonists to checkpoint receptors. Methods: This is an ongoing dose-escalation study of INCB024360 combined with ipi (3 mg/kg IV q 3 wks x 4) in pts with metastatic melanoma. Enrollment in 2 cohorts (300 mg BID, 25 mg BID) is complete. Toxicity, ORR (irRC), Duration of Response (DoR), and OS were evaluated. The DLT evaluation period was 8 wks andassessments for response were every 9 wks. Results: Seven pts were enrolled at 300 mg BID. When 5 pts developed clinically significant ALT elevations after 30–76 days on treatment, enrollment was stopped. ALT elevations were reversible with corticosteroids and treatment discontinuation. Six of 7 pts had evaluable on-study scans prior to discontinuation and all showed irSD. Time to subsequent therapy was >90 days in all 7 pts and >180 days in 4 of 7 pts. Enrollment was restarted at 25 mg BID (n=8), where 1 pt with progression of prior extensive liver metastases had a DLT (G3 AST elevation). Immune-related AEs (irAEs) were generally G1/2 and manageable with continued dosing or temporary dose interruption; 1 pt each discontinued for G3 colitis and G3 salivary amylase elevation. Six of 8 pts had tumor reduction by the 1st evaluation. Confirmed disease control rate was 75% (6/8). Three pts had confirmed irPR (2 occurred by the 1st or 2nd scan); DoR was 179, 148, and >127 (ongoing) days. Three pts had irSD for 116, >173 (ongoing), and >187 (ongoing) days. Pharmacodynamic effects at 25 mg BID were similar to those that were sufficient in preclinical models to achieve maximal therapeutic effect. A 50 mg BID cohort is enrolling. Conclusions: INCB024360 25 mg BID with ipi was generally well tolerated and irAEs previously observed with ipi were reversible with appropriate management. Tumor response and duration data suggest the potential for enhanced melanoma patient outcomes compared to ipi monotherapy. Clinical trial information: NCT01604889.
Outdoor PM <sub>2.5</sub> , Ambient Air Temperature, and Asthma Symptoms in the Past 14 Days among Adults with Active Asthma
Authors: Maria C. Mirabelli, Ambarish Vaidyanathan, W. Dana Flanders, Xiaoting Qin, Paul Garbe
Journal: Environmental Health Perspectives (2016)

Relationships between air quality and health are well-described, but little information is available about the joint associations between particulate air pollution, ambient temperature, and respiratory morbidity.We evaluated associations between concentrations of particulate matter ≤ 2.5 μm in diameter (PM2.5) and exacerbation of existing asthma and modification of the associations by ambient air temperature.Data from 50,356 adult respondents to the Asthma Call-back Survey from 2006-2010 were linked by interview date and county of residence to estimates of daily averages of PM2.5 and maximum air temperature. Associations between 14-day average PM2.5 and the presence of any asthma symptoms during the 14 days leading up to and including the interview date were evaluated using binomial regression. We explored variation by air temperature using similar models, stratified into quintiles of the 14-day average maximum temperature.Among adults with active asthma, 57.1% reported asthma symptoms within the past 14 days, and 14-day average PM2.5 ≥ 7.07 μg/m3 was associated with an estimated 4-5% higher asthma symptom prevalence. In the range of 4.00-7.06 μg/m3 of PM2.5, each 1-μg/m3 increase was associated with a 3.4% [95% confidence interval (CI): 1.1, 5.7] increase in symptom prevalence; across categories of temperature from 1.1 to 80.5°F, each 1-μg/m3 increase was associated with increased symptom prevalence (1.1-44.4°F: 7.9%; 44.5-58.6°F: 6.9%; 58.7-70.1°F: 2.9%; 70.2-80.5°F: 7.3%).These results suggest that each unit increase in PM2.5 may be associated with an increase in the prevalence of asthma symptoms, even at levels as low as 4.00-7.06 μg/m3. Citation: Mirabelli MC, Vaidyanathan A, Flanders WD, Qin X, Garbe P. 2016. Outdoor PM2.5, ambient air temperature, and asthma symptoms in the past 14 days among adults with active asthma. Environ Health Perspect 124:1882-1890; http://dx.doi.org/10.1289/EHP92.
Proton Pump Inhibitors and Dementia Incidence
Authors: Helge L. Waldum, Tom Christian Martinsen
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
The Pediatrician
Authors: Leo B. Burgin
Journal: New England Journal of Medicine (1973)

Dr. Garland gave up his pediatric career about halfway through his professional life. To interpret his impact on the local scene it is necessary to project oneself back to the era during which he practiced. Pediatrics at that time concerned itself with infant feeding, respiratory infections and diarrheal disease. For the most part this was largely on a clinical level. Laboratory investigations were just beginning in pediatrics. Indeed, the Children's Medical Service at the Massachusetts General Hospital was founded by the late Fritz B. Talbot only in 1911. Dr. Garland had graduated from Harvard Medical School in 1919. I recall . . .
A Model for Human B-Chronic Lymphocytic Leukemia in Human/Mouse Radiation Chimera: Evidence for Tumor-Mediated Suppression of Antibody Production in Low-Stage Disease
Authors: Avichai Shimoni, Hadar Marcus, Allon Canaan, David Ergas, Magda David, Alain Berrebi, Yair Reisner
Journal: Blood (1997)
Heterozygous STAT1 gain-of-function mutations underlie an unexpectedly broad clinical phenotype
Authors: Julie Toubiana, Satoshi Okada, Julia Hiller, Matias Oleastro, Macarena Lagos Gomez, Juan Carlos Aldave Becerra, Marie Ouachée-Chardin, Fanny Fouyssac, Katta Mohan Girisha, Amos Etzioni, Joris Van Montfrans, Yildiz Camcioglu, Leigh Ann Kerns, Bernd Belohradsky, Stéphane Blanche, Aziz Bousfiha, Carlos Rodriguez-Gallego, Isabelle Meyts, Kai Kisand, Janine Reichenbach, Ellen D. Renner, Sergio Rosenzweig, Bodo Grimbacher, Frank L. van de Veerdonk, Claudia Traidl-Hoffmann, Capucine Picard, Laszlo Marodi, Tomohiro Morio, Masao Kobayashi, Desa Lilic, Joshua D. Milner, Steven Holland, Jean-Laurent Casanova, Anne Puel
Journal: Blood (2016)
Case 33-1965
Authors: John M. Moses, Benjamin Castleman
Journal: New England Journal of Medicine (1965)

Presentation of CaseA sixty-nine-year-old man was admitted to the hospital because of dyspnea.He had been well until the development of anorexia ten weeks previously, followed two weeks later by the onset of night sweats and chilly sensations. Three weeks before admission a physician found pyuria and administered sulfisoxazole (Gantrisin), which caused improvement of the signs in the urinary sediment. Intermittent glycosuria was observed, and the fasting serum glucose was 140 mg. per 100 ml. The anorexia, sweating and chilliness persisted, and profound weakness developed. For several days before entry he vomited intermittently and ingested only small amounts of . . .
An overview of the HIV epidemic among men who have sex with men in the United Kingdom, 1999–2013
Authors: S Desai, S Croxford, A E Brown, H Mitchell, G Hughes, V Delpech
Journal: Eurosurveillance (2015)

We describe epidemiological trends in HIV among men who have sex with men (MSM) in the United Kingdom (UK) to inform prevention strategies. National HIV surveillance data were analysed for trends. Multivariable analyses identified predictors of late diagnosis (&lt;350 copies/µL) and mortality. Between 1999 and 2013, 37,560 MSM (≥15 years) were diagnosed with HIV in the UK. New diagnoses rose annually from 1,440 in 1999 to 3,250 in 2013. The majority of MSM were of white ethnicity (85%) and UK-born (68%). Median CD4 count increased steadily from 350 cells/µL to 463 cells/µL. HIV testing in England increased from 10,900 tests in 1999 to 102,600 in 2013. One-year death rates after diagnosis declined among late presenters (4.7% to 1.9%). Despite declining late diagnosis (50% to 31%), the number of men diagnosed late annually has remained high since 2004. Older age (≥50 years), and living outside London were predictors of late presentation; older age and late presentation were predictors of one-year mortality. Increases in new diagnoses reflect increased testing and ongoing transmission. Over 900 men present late each year and mortality in this group remains high and preventable. Appropriate prevention and testing strategies require strengthening to reduce HIV transmission and late diagnosis.
Lessons From Australia’s National Firearms Agreement
Authors: Daniel W. Webster
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Case 25-1962
Authors: Vincent P. Perlo, Robert E. Scully
Journal: New England Journal of Medicine (1962)

Presentation of CaseAn eighty-year-old woman was admitted to the hospital because of loss of consciousness.On the day of admission the patient rolled out of bed, striking her head on the floor. For the next twenty minutes she was lucid and spoke normally to her husband, but thereafter she became drowsy and then comatose and was brought to the hospital immediately.For many years the patient had diabetes mellitus, which was controlled by diet. Five years previously she was admitted to the hospital because of acute diverticulitis; a left-sided colectomy was performed, and she recovered uneventfully. Shortly thereafter a . . .
An effect of pharmacotherapy on the psychoanalytic process: case report of a modified analysis
Authors: H W Wylie, M L Wylie
Journal: American Journal of Psychiatry (1987)

A woman who had appeared suitable for psychoanalysis was persistently unable to develop an analyzable transference. Her history, as it unfolded during analysis, suggested a form of atypical depression linked to a neurochemical abnormality, which appeared to be related to her reluctance to take the emotional risk involved in examining transference phenomena. The analysis was modified by a trial of phenelzine. Changes within the analysis and in the patient's private life after the drug trial ended support the hypothesis that her affective vulnerability had inhibited her ability to engage in analysis of transference before the administration of the drug.
Morphological Evidence for the Association of Virus Particles With the Pancreatic Acinar Cells of the Chick
Authors: Robert F. Zeigel
Journal: JNCI Journal of the National Cancer Institute (1961)

Particles, apparently morphologically identical to virus particles described in various avian systems, “budded” or formed from the apical plasma membrane of pancreatic acinar cells in 5 of 12 chicks and embryos chosen at random from “normal” colonies. The particles were composed of two concentric, dense membranes with a centrally located, dense nucleoid, and their diameter was approximately 800 A. The lungs, livers, kidneys, hearts, spleens, and intestines of these 5 chicks contained morphologically identical particles in intercellular spaces, intracytoplasmic vesicles, and vacuoles. When particles were not associated with the pancreas of several birds, they could not be found in other organs. The significance of this observation in relation to avian neoplasms and normal tissues is discussed.
MALIGNANT DISEASE OF THE VERMIFORM APPENDIX.
Authors: V D Schaffner
Journal: JAMA (1902)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Journals JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2024 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA
Authors: Federico Iovino, Disa L. Hammarlöf, Genevieve Garriss, Sarah Brovall, Priyanka Nannapaneni, Birgitta Henriques-Normark
Journal: Journal of Clinical Investigation (2016)

Streptococcus pneumoniae (pneumococcus) is the primary cause of bacterial meningitis. Pneumococcal bacteria penetrates the blood-brain barrier (BBB), but the bacterial factors that enable this process are not known. Here, we determined that expression of pneumococcal pilus-1, which includes the pilus adhesin RrgA, promotes bacterial penetration through the BBB in a mouse model. S. pneumoniae that colonized the respiratory epithelium and grew in the bloodstream were chains of variable lengths; however, the pneumococci that entered the brain were division-competent, spherical, single cocci that expressed adhesive RrgA-containing pili. The cell division protein DivIVA, which is required for an ovoid shape, was localized at the poles and septum of pneumococcal chains of ovoid, nonseparated bacteria, but was absent in spherical, single cocci. In the bloodstream, a small percentage of pneumococci appeared as piliated, RrgA-expressing, DivIVA-negative single cocci, suggesting that only a minority of S. pneumoniae are poised to cross the BBB. Together, our data indicate that small bacterial cell size, which is signified by the absence of DivIVA, and the presence of an adhesive RrgA-containing pilus-1 mediate pneumococcal passage from the bloodstream through the BBB into the brain to cause lethal meningitis.
P2-011: Occurrence and clinical significance of hOGG1 Ser326Cys polymorphism in NSCLC patients from Northern Poland
Authors: Adrianna Drozdowska, Amelia Szymanowska, Ewa Jassem, Magdalena Ratajska, Krzysztof Konopa, Witold Rzyman, Grazyna Kobierska-Gulida, Janusz Limon, Jacek Jassem
Journal: Journal of Thoracic Oncology (2007)