tbuckley/cabot-search huggingface dataset:
Questionnaire survey analysis for awareness of multidisciplinary medical staff in Nara for exposure to anti-cancer drugs
Authors: Naoko Kubo, Yumi Yoshii, Yumi Nakamura, Setsuko Kajii, Yusaku Akashi, Teruhisa Azuma, Shinya Kobayashi, Hiroshi Koyama, Yukishige Yamada, Masatoshi Kanno
Journal: Annals of Oncology (2015)
P09.06 Withdrawal of antiepileptic drugs in glioma patients after long-term seizure freedom
Authors: M. Kerkhof, J. A. F. Koekkoek, M. J. Vos, M. J. van den Bent, W. Taal, T. J. Postma, J. E. C. Bromberg, L. Dirven, J. C. Reijneveld, M. J. B. Taphoorn
Journal: Neuro-Oncology (2016)
Predictors of Unsuccessful Mobilization with Granulocyte-Colony Stimulating Factor (G-CSF) Alone In Patients with Hematological Malignancies Undergoing Autologous Hematopoietic Stem Cell (AHSCT) Transplant
Authors: Signy Chow, D. George Ormond, Alejandro Lazo-Langner, Kang Howson-Jan, Anargyros Xenocostas
Journal: Blood (2010)
Association of Serum Level of Vitamin D at Diagnosis With Breast Cancer Survival
Authors: Song Yao, Marilyn L. Kwan, Isaac J. Ergas, Janise M. Roh, Ting-Yuan David Cheng, Chi-Chen Hong, Susan E. McCann, Li Tang, Warren Davis, Song Liu, Charles P. Quesenberry, Marion M. Lee, Christine B. Ambrosone, Lawrence H. Kushi
Journal: JAMA Oncology (2016)

There are long-standing interests in the potential benefits of vitamin D for preventing breast cancer recurrence and mortality, yet data from prospective cohort studies are limited.To investigate a serum biomarker of vitamin D status, 25-hydroxyvitamin D (25OHD) measured at the time of breast cancer diagnosis, to determine the association with prognosis.The Pathways Study is a prospective cohort study of breast cancer survivors established in 2006. Enrollment was completed in 2013; follow-up is ongoing. The cohort was established in Kaiser Permanente Northern California, a large integrated health care delivery system in northern California. Women with a diagnosis of incident invasive breast cancer were typically consented and enrolled within 2 months of diagnosis. The overall enrollment rate was 46% (4505 of 9820). Participants are followed for health outcomes and comorbidities at 12, 24, 48, 72, and 96 months after baseline interview. A case-cohort design was used for efficiency assay of 25OHD, selecting 1666 cohort members with serum samples and ensuring representation in the subcohort of races and clinical subtypes. The data analysis was performed from January 5, 2014, to March 15, 2015.Primary outcomes are breast cancer recurrence, second primary cancer, and death.Mean (SD) age was 58.7 (12.4) years. Serum 25OHD concentrations were lower in women with advanced-stage tumors, and the lowest in premenopausal women with triple-negative cancer. Levels were also inversely associated with hazards of disease progression and death. Compared with the lowest tertile, women with the highest tertile of 25OHD levels had superior overall survival (OS). This association remained after adjustment for clinical prognostic factors (hazard ratio [HR], 0.72; 95% CI, 0.54-0.98). Among premenopausal women, the association with OS was stronger, and there were also associations with breast cancer-specific survival and invasive disease-free survival (OS: HR, 0.45; 95% CI, 0.21-0.96; breast cancer-specific survival: HR, 0.37; 95% CI, 0.15-0.93; invasive disease-free survival: HR, 0.58; 95% CI, 0.34-1.01; all after full adjustment).Serum 25OHD levels were independently associated with breast cancer prognostic characteristics and patient prognosis, most prominently among premenopausal women. Our findings from a large, well-characterized prospective cohort provide compelling observational evidence on associations of vitamin D with lower risk of breast cancer morbidity and mortality.
Response to Comment on Crews et al. Role and Determinants of Adherence to Off-loading in Diabetic Foot Ulcer Healing: A Prospective Investigation. Diabetes Care 2016;39:1371–1377
Authors: Ryan T. Crews, Biing-Jiun Shen, Laura Campbell, Peter J. Lamont, Matthew Hardman, Andrew J.M. Boulton, Mark Peyrot, Robert S. Kirsner, Loretta Vileikyte
Journal: Diabetes Care (2016)

We were pleased that van Netten et al. (1) appreciate the importance of our article (2) substantiating the relationship between adherence to off-loading modalities and healing of diabetic foot ulcers (DFUs). Their letter contained several comments regarding our article that we address here.

The first comment by van Netten et al. is regarding the rationale for using a surrogate clinical outcome (ulcer area reduction) rather than ulcer healing by a fixed time, preferably 12 weeks, which would allow for direct comparisons with other articles on off-loading. It is important to note, as was outlined in our article, that the study associated with our publication was not limited …
The influence of diabetes mellitus on clinical outcome following multivessel stenting or CABG in the ARTS trial
Authors: PW Serruys, MA Costa, A Betriu, AJ van Boven, [No Value] Voudris, K Saunamaki, VG Ribeiro, W Rutsch, Jhh Bett, JJ Dubois-Rande, [No Value] de Valk, F Unger
Journal: Circulation (1999)
SAT0092 Prevalence of Subclinical Inflammation in Patients with Rheumatoid Arthritis Who Have Low Disease Activity: Table 1
Authors: Y.-C. Chen, J.-F. Chen, T.-T. Cheng
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Studies using ultrasound (US) showed that a significant proportion of patients thought to be in clinical remission actually exhibited different grades of synovitis, and a subgroup of these patients suffered from flares and/or joint damage during follow-up<sup>1</sup>. <h3>Objectives</h3> Evaluate joint inflammation by ultrasound in patients with different stages of rheumatoid arthritis as the primary endpoint measure. <h3>Methods</h3> Gray scale and power Doppler ultrasound were performed on the dorsal radio-scaphoid, dorsal radio-lunae, ulnar-triquetrium, and palmar radio-lunate joints of both wrists. The presence of synovitis, comorbidities, and use of disease modifying anti-rheumatic drugs were recorded. Patient with a bilateral wrist score sum (GSUS + PDUS) equal or greater than 4 was considered to have sonographic inflammation. A logistical regression model was used to identify factors associated with inflammation. <h3>Results</h3> There were 1248 patients (1010 females, 238 males; mean age: 59.61 ± 12.19 years). Synovitis was most common at the dorsal radio-lunate joint. Patients with high disease activity (DAS28 &gt;5.1) had more sonographic inflammation than those with moderate or low disease activity. Most patients (57.4%) in complete remission (DAS28 &lt;2.6) had subclinical synovitis (Table). Logistical regression analysis indicated that male sex, smoking, and liver disease are positively associated with inflammation and that advanced age, alcohol consumption, hypertension, gastrointestinal disease, and use of MTX, glucocorticoid, or a biological therapy are negatively associated with inflammation. Use of biological agents decreased the risk of inflammation by 40.9%. <h3>Conclusions</h3> There was sonographic evidence of synovitis in most patients who were in complete remission. Regular monitoring of rheumatoid arthritis patients with ultrasound and DAS28 may help prevent disease flare-ups and joint destruction. <h3>References</h3> Brown AK, et al. Arthritis and Rheumatism 2006;54:3761–3773. <h3>Disclosure of Interest</h3> None declared
Inclusion of Total BODY Computed Tomography (TB-CT) SCANS In the INITIAL WORK-up of Binet STAGE A CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PATIENTS On CLINICAL Grounds: PRELIMINARY RESULTS of the Prospective, MULTICENTER O-CLL1- GISL STUDY
Authors: Massimo Gentile, Giovanna Cutrona, Sonia Fabris, Emanuela Anna Pesce, Francesco Maura, Francesco Di Raimondo, Caterina Musolino, Paolo Di Tonno, Nicola Di Renzo, Luciano Levato, Maura Brugiatelli, Francesco Merli, Simonetta Zupo, Serena Matis, Fiorella Ilariucci, Francesco Angrilli, Giovanni Quarta, Emilio Iannitto, Alberto Fragasso, Stefano Molica, Pellegrino Musto, Mauro Spriano, Iolanda Vincelli, Daniele Vallisa, Agostino Cortelezzi, Robin Foà, Massimo Federico, Antonino Neri, Manlio Ferrarini, Fortunato Morabito
Journal: Blood (2011)
Conditional Expression of C/EBPα in Mice Reveals Developmental Plasticity of Lymphoid and Erythroid/ Megakaryocyte Precursors in Vivo.
Authors: Yumi Fukuchi, Fumi Shibata, Miyuki Ito, Yuko Goto-Koshino, Yusuke Sotomaru, Mamoru Ito, Toshio Kitamura, Hideaki Nakajima
Journal: Blood (2004)
CRLF2 Rearrangement Is Not Associated with Activated mTOR Pathway in NOD/SCID/huALL Xenograft Mouse Model.
Authors: Md. Nabiul Hasan, Silvia Bresolin, Ilaria Bronzini, Chiara Palmi, Manon Queudeville, Sarah Mirjam Eckhoff, Luca Trentin, Giovanni Cazzaniga, Geertury te Kronnie, Klaus-Michael Debatin, Lüder-Hinrich Meyer
Journal: Blood (2012)
Whole Genome Sequencing On Donor Cell Leukemia in a Patient with Multiple Myeloma Identified Gene Mutations That May Provide Insights to Leukemogenesis.
Authors: Eric S.K. Ho, Howard C.H. Chow, Chris T.L. Chan, Ruibang Luo, Henry C.M. Leung, Siu Ming Yiu, Francis Y.L. Chin, Yok Lam Kwong, Anskar Y.H. Leung
Journal: Blood (2012)
SAT0274 Indirect Comparison of Biological Agents in Juvenile Idiopathic Arthritis: Meta-Analysis of Randomized Controlled Trials
Authors: M. Fan, J. Liu, B. Zhao, P. Zhang, Y. Mou, J. Gu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood. Recent advances in biologics have greatly changed the prognosis of JIA. <h3>Objectives</h3> To evaluate the efficacy and safety of biological agents in patients with JIA. <h3>Methods</h3> We included all randomized controlled trials (RCTs) that compared biologics with placebo in JIA patients. According to the American College of Rheumatology Pediatric (ACR Pedi) criteria, the proportions of patients reaching 30%, 50% or 70% improvement (ACR Pedi 30/50/70) or suffering disease flare were used as the efficacy outcomes. Adverse events (AEs), infections and severe AEs were applied to evaluate the safety. The biological agents were pooled to perform comparison with placebo and among themselves, calculating odds ratios, probability of being best (P<sub>best</sub>) and numbers needed to treat (NNT). <h3>Results</h3> Sixteen RCTs totaling 18 reports (1689 patients) were included in the analysis focusing on 4 different types of biologics, i.e. tumor necrosis factor (TNF) inhibitors (etanercept, infliximab, adalimumab and golimumab), anti-interleukin-1 agents (anakinra, rilonacept, canakinumab), anti-interleukin-6 agent (tocilizumab) and cytotoxic lymphocyte-associated antigen-4 agent (abatacept). All biological agents were efficacious in achieving ACR Pedi 30/50/70 responses and preventing disease flare compared with placebo but with a higher risk of infections. No significant differences in efficacy were found among biologics, except that tocilizumab had a higher rate of ACR Pedi 30 response than TNF inhibitors. And for ACR Pedi 30/50/70 responses, tocilizumab was ranked the most effective option with NNT of 2 (P<sub>best</sub> 89.9%, 82.3% and 48.4%, respectively). <h3>Conclusions</h3> Compared to placebo, biologics are all effective in the treatment of JIA but with a higher risk of infections. Tocilizumab is more likely to achieve ACR Pedi 30/50/70 responses. <h3>References</h3> Petty RE, Southwood TR, Manners P, Baum J, Glass DN, Goldenberg J, et al. International League of Associations for Rheumatology classification of juvenile idiopathic arthritis: second revision, Edmonton, 2001. The Journal of rheumatology. 2004;31(2):390–2. Ilowite NT. Update on biologics in juvenile idiopathic arthritis. Current opinion in rheumatology. 2008;20(5):613–8. Otten MH, Anink J, Spronk S, van Suijlekom-Smit LW. Efficacy of biological agents in juvenile idiopathic arthritis: a systematic review using indirect comparisons. Annals of the rheumatic diseases. 2013;72(11):1806–12. <h3>Disclosure of Interest</h3> None declared
EU to launch new antimicrobial resistance action plan
Authors: Rory Watson
Journal: BMJ (2016)

The European Commission is putting the finishing touches on a new five year antimicrobial resistance (AMR) action plan, which will be launched next year.

Confirmation that the various EU supported activities to tackle AMR would continue after the current plans expire at the end of the year coincided with the publication of new data by the European Centre for Disease Prevention and Control (ECDC).1

The data showed that, in 2015, antibiotic resistance continued to increase for most bacteria and antibiotics that the agency keeps under surveillance. In particular, carbapenem resistance …
Immunoglobulin E Autoantibodies in Bullous Pemphigoid Detected by Immunoglobulin E Enzyme-Linked Immunosorbent Assays
Authors: Takashi Hashimoto, Daisuke Tsuruta, Norito Ishii
Journal: JAMA Dermatology (2016)

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The Cumulative Dose But Not The Frequency Of Infusions Is a Risk Factor For The Development Of Osteonecrosis Of The Jaw (ONJ) In Myeloma Patients Who Receive Zoledronic Acid (ZA)
Authors: Efstathios Kastritis, Evangelos Terpos, Ioannis Melakopoulos, Pelagia Melea, Despoina Kalapanida, Maria Roussou, Maria Gavriatopoulou, Nikolaos Kanellias, Marina Iakovaki, Dimitrios Christoulas, Dimitra Gika, Meletios A. Dimopoulos
Journal: Blood (2013)
Expression of the 67-kDa Laminin Receptor Is Associated with Increased AML Cells through the Enhanced GM-CSF/Stat5 Signaling.
Authors: Koji Ando, Yasushi Miyazaki, Yasushi Sawayama, Kensuke Horio, Emi Matsuo, Reishi Yamasaki, Yoriko Inoue, Masako Iwanaga, Daisuke Imanishi, Hideki Tsushima, Shinichiro Yoshida, Jun Taguchi, Tomoko Hata, Masao Tomonaga
Journal: Blood (2007)
Proline-Rich Tyrosine Kinase (Pyk2) Promotes Tumor Progression in Multiple Myeloma (MM) and Represents a Novel Target for Therapy in MM
Authors: Yu Zhang, Yong Zhang, Yuji Mishima, Michele Moschetta, Wenjing Zhang, Patricia Maiso, Antonio Sacco, Yosra Aljawai, Ilyas Sahin, Michaela R. Reagan, Jennifer E. Ring, Winnie F. Tam, Qunli Xu, Jonathan A. Pachter, Aldo M Roccaro, Irene M. Ghobrial
Journal: Blood (2014)
SAT0475 Health System Frustration Expressed by Patients with Knee Osteoarthritis
Authors: V. Salaru, V. Sadovici-Bobeica, L. Mazur-Nicorici, A. Stirbul, T. Rotaru, M. Mazur
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Objectives</h3> To explore the challenges experienced by patients with knee osteoarthritis. <h3>Methods</h3> A structured interview was conducted with patients that fulfilled the ACR classification criteria for knee osteoarthritis (OA) (1991). We collected data on demographic and socioeconomic characteristics, use of health and social services, and effect on occupation and living arrangements over the previous 12 months. The patients completed Knee Osteoarthritis Outcomes Score (KOOS) and Patient Satisfaction Questionnaire. This study was conducted according to the principles of the Declaration of Helsinki (1996) and Good Clinical Practice. <h3>Results</h3> There were 51 patients enrolled in the study including 39 females (76,5%), mean age 64,45 ±8,07 (range 50–82) and the disease duration was 9,9±6,97 (range 2–24) years. Knee pain was present in 49 (96%) of patients. The radiographic characteristics: KL I – 1 (1,9%), II – 29 (56,9%) patients, KLIII – 17 (33,3%) and the most severe form KLIV – 4 (7,9%) cases. The KOOS results showed that Pain was 59,6±20,6%, Symptoms 63,74±17,38%, Activity Daily Living – 45,35±21,1%, the possibility to practice sport was the worse score 25,69±25,2%, and the QoL-37,66±28,88% qualified as low. Patients notice health system frustration: poor communication (70,6%), uncoordinated health services (86,2%), lack of efficient and timely information (41,2%), that determine the difficulties in making decisions about their care. The patients in 50 (98,0%) cases manifested a high level of dissatisfaction with financial aspects (the out-pocket expenders representing 29,7% from incomes) and low level of social support. <h3>Conclusions</h3> Patients with knee osteoarthritis experience social-economic and organizational difficulties, their pointing could lead to the improvement of the quality of medical care and increased patient9s satisfaction. <h3>Disclosure of Interest</h3> None declared
Intake of individual saturated fatty acids and risk of coronary heart disease in US men and women: two prospective longitudinal cohort studies
Authors: Geng Zong, Yanping Li, Anne J Wanders, Marjan Alssema, Peter L Zock, Walter C Willett, Frank B Hu, Qi Sun
Journal: BMJ (2016)

<b>Objectives</b>&nbsp;To investigate the association between long term intake of individual saturated fatty acids (SFAs) and the risk of coronary heart disease, in two large cohort studies. <b>Design</b>&nbsp;Prospective, longitudinal cohort study. <b>Setting</b>&nbsp;Health professionals in the United States. <b>Participants</b>&nbsp;73 147 women in the Nurses’ Health Study (1984-2012) and 42 635 men in the Health Professionals Follow-up Study (1986-2010), who were free of major chronic diseases at baseline. <b>Main outcome measure</b>&nbsp;Incidence of coronary heart disease (n=7035) was self-reported, and related deaths were identified by searching National Death Index or through report of next of kin or postal authority. Cases were confirmed by medical records review. <b>Results</b>&nbsp;Mean intake of SFAs accounted for 9.0-11.3% energy intake over time, and was mainly composed of lauric acid (12:0), myristic acid (14:0), palmitic acid (16:0), and stearic acid (18:0; 8.8-10.7% energy). Intake of 12:0, 14:0, 16:0 and 18:0 were highly correlated, with Spearman correlation coefficients between 0.38 and 0.93 (all P&lt;0.001). Comparing the highest to the lowest groups of individual SFA intakes, hazard ratios of coronary heart disease were 1.07 (95% confidence interval 0.99 to 1.15; P<sub>trend</sub>=0.05) for 12:0, 1.13 (1.05 to 1.22; P<sub>trend</sub>&lt;0.001) for 14:0, 1.18 (1.09 to 1.27; P<sub>trend</sub>&lt;0.001) for 16:0, 1.18 (1.09 to 1.28; P<sub>trend</sub>&lt;0.001) for 18:0, and 1.18 (1.09 to 1.28; P<sub>trend</sub>&lt;0.001) for all four SFAs combined (12:0-18:0), after multivariate adjustment of lifestyle factors and total energy intake. Hazard ratios of coronary heart disease for isocaloric replacement of 1% energy from 12:0-18:0 were 0.92 (95% confidence interval 0.89 to 0.96; P&lt;0.001) for polyunsaturated fat, 0.95 (0.90 to 1.01; P=0.08) for monounsaturated fat, 0.94 (0.91 to 0.97; P&lt;0.001) for whole grain carbohydrates, and 0.93 (0.89 to 0.97; P=0.001) for plant proteins. For individual SFAs, the lowest risk of coronary heart disease was observed when the most abundant SFA, 16:0, was replaced. Hazard ratios of coronary heart disease for replacing 1% energy from 16:0 were 0.88 (95% confidence interval 0.81 to 0.96; P=0.002) for polyunsaturated fat, 0.92 (0.83 to 1.02; P=0.10) for monounsaturated fat, 0.90 (0.83 to 0.97; P=0.01) for whole grain carbohydrates, and 0.89 (0.82 to 0.97; P=0.01) for plant proteins. <b>Conclusions</b>&nbsp;Higher dietary intakes of major SFAs are associated with an increased risk of coronary heart disease. Owing to similar associations and high correlations among individual SFAs, dietary recommendations for the prevention of coronary heart disease should continue to focus on replacing total saturated fat with more healthy sources of energy.
FRI0474 Serum Level of IL-23 and IL-23R Polymorphisms in Patients with Psoriatic Arthritis
Authors: R. Sokolik, K. Gebura, L. Korman, B. Wysoczanska, P. Wiland, K. Bogunia-Kubik
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Interleukin (IL) - 23 is one of the of cytokines involved in systemic inflammation. Interaction between this cytokine and its receptor (IL-23R) that plays an important role in pathogenesis of psoriatic arthritis (PsA). <h3>Objectives</h3> The present study aimed to assess the associations between polymorphisms within gene coding IL-23R, IL-23 serum levels and disease activity in patients with PsA. <h3>Methods</h3> Fifty-two PsA patients (diagnosed by the criteria recommended by CASPAR group) were genotyped for the IL-23R (rs11209026 and rs7530511) polymorphisms. The nuclear factor kappa (NF-kB1 (rs28362491; ins/del)) polymorphism (associated with the promoter activity of this gene and cytokine gene expressions, including IL-23) was also analyzed in PsA patients group. IL-23 serum levels were assessed by ELISA in patients with PsA, and for comparison, 10 healthy individuals. These laboratory data were further related with clinical characteristics of the patients. Disease Activity Score was measured (swollen and tender joints, ESR, CRP) in addition to BASDAI, BASFI, VAS, and PASI scores. <h3>Results</h3> Significantly (p&lt;0.05) elevated levels of IL-23 cytokine were observed in PsA patients (126.5 pg/ml) when compared to control group (24.9 pg/ml). Moreover, IL-23 serum levels were associated with the IL-23R rs7530511 polymorphism. Patients carrying the IL-23R T allele characterized with higher concentrations of IL-23 in serum (299.1 vs 86.8, p&lt;0.05). Interestingly, patients with the IL-23R T allele were also more frequently carrying the ins/ins homozygous NF-kB1 genotype (associated with a better promoter activity and higher expression of cytokines) (7/17 vs 4/34, distribution of the T allele among ins/ins vs del allele positive patients, p=0.03). No association was found between for IL-23 levels or IL-23R polymorphisms and disease activity. <h3>Conclusions</h3> Patients with PsA characterize with higher serum levels of IL-23 than healthy individuals. IL-23 concentrations in serum of PsA patients are associated with the polymorphism (rs7530511) of IL-23 receptor encoding gene. <h3>Disclosure of Interest</h3> None declared
Genome-Wide Profiling of High-Risk Pediatric Acute Lymphoblastic Leukemia (ALL): The ALL Pilot Project for the Therapeutically Applicable Research To Generate Effective Treatments (TARGET) Initiative.
Authors: Charles G. Mullighan, Xiaoping Su, Jing Ma, Wenjian Yang, Mary V. Relling, William L. Carroll, Gregory Reaman, Paul Bowman, Meenakshi Devidas, Stephen P. Hunger, James R. Downing
Journal: Blood (2007)