tbuckley/cabot-search huggingface dataset:
AB0717 Effect of mechanical stress into the ultrasonographic assessment of healthy subjects: the monday’s synovitis
Authors: C. A. Guillen Astete, C. Sobrino Grande, M. Ahijón Lana, A. Zea Mendoza
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Musculoskeletal ultrasonography (MUS) is been considered as a useful tool for the study of patients with inflammatory rheumatic diseases due to its capacity to detect subclinic synovitis. Because of that, it is imperative to exclude other causes of synovitis that could be present in healthy people as well. In our experience, physical overexertion is performed by people, most frequently on weekends. According to that, it seems reasonable to assume that an ultrasonographic assessment performed after a weekend could detect not only synovitis related to a chronic inflammatory rheumatic disease but also acute changes related to overexertion, however, as far as we know, there is no study that demonstrated the effect of overexertion among ultrasonography findings in joints of healthy people. <h3>Objectives</h3> The aim of present study is to compare the proportion of synovitis detected by MUS in healthy subjects according to their self evaluation of exertion level the day before. <h3>Methods</h3> Four hundred and seven consecutive volunteers were enrolled in a 12 month period. A MUS of carpal, second and third metacarpophalangeal joints were performed in both hands. All studies took place in Monday or Friday. Subjects were grouped according self evaluation of level of exertion the day before (usual activity or overexertion). Presence or absence of synovitis were compared between both groups and according to the hand studied (dominant or not). Every MUS were performed with a 10-13 MHz linear probe. <h3>Results</h3> 4.2% of subjects studied on Fridays and 30.2% of subjects studied on Monday reported an overexertion the day before (p&lt;0.001, contingency coefficient 0.331). In the dominant hand proportions of synovial hypertrophy, synovial effusion and power Doppler signal were 29.6, 12.6 and 9.1% respectively in patients who reported overexertion and 11.1, 5.4 and 3.9% respectively in patients who reported usual activity (p&lt;0.05 in all comparisons). Those differences were not observed when comparisons of the not dominant hand were performed. Presence of any finding related to synovitis (synovial effusion or hypertrophy) was statistically higher in subjects studied on Mondays compared to Fridays (34.9 and 12.1%, respectively) and in subjects who informed an overexertion the day before compared to subjects who did not (47.7 and 11.5%, respectively). <h3>Conclusions</h3> After a physical overexertion, the probability of detection of synovitis is higher compared to subjects who performed usual activities. In general, we recommend performing MUS after usual activity in order to minimize the chance of detecting synovitis related to overexertion. Also, whenever is possible, is recommendable to chose non dominant joints (research, non symptomatic people) when the MUS is performed close to a recent overexertion. <h3>Disclosure of Interest</h3> None Declared
PTU-079 The Inflammatory Bowel Disease Quality Improvement Project – Progress Two Years on
Authors: I Shaw, E Fernandez
Journal: Gut (2013)

<h3>Introduction</h3> The IBD Quality Improvement Project (IBDQIP) was established in 2010, as a project to help improve adult and paediatric IBD services across the UK. Here we report the first two years of progress. <h3>Methods</h3> IBDQIP uses a web-based system (www.ibdqip.co.uk) to enable services to benchmark themselves against the national IBD standards and then action plan improvement using a combination of self-assessment, network support and a shared repository of best practise. Results are provided to sites graphically as a performance dashboard using a hierarchical grading system. Initial sites completed the first assessment in 2011, with a second round in 2012. Progress has been assessed by comparing scores between rounds and from site feedback. <h3>Results</h3> Participation increased over time, with 69 sites (56 adult &amp; 13 paediatric) participating in round 1 (2011) and 84 sites (66 adult &amp; 18 paediatric) in round 2 (2012). 90% of sites completed their evaluation within 4 hours (median 2–3). 60% of sites met as an MDT to complete their return, which was rated as the most powerful catalyst for change (figure 1). Significant improvement has been made across a range of measures: <h3>Conclusion</h3> In it’s first two years, IBDQIP has shown increased participation and has proved to be a rapid and effective tool to improve IBD services. The project has now merged with the National IBD Audit and will be rolled out to all IBD services in 2014. <h3>Disclosure of Interest</h3> None Declared
Open-Heart Surgery without the Need for Donor-Blood Priming in the Pump Oxygenator
Authors: Wilford B. Neptune, James A. Bougas, Frederick G. Panico
Journal: New England Journal of Medicine (1960)

THIS is a report of a pump-oxygenator system and a technic for extracorporeal perfusion without the use of donor blood for priming. Such a technic yields increased safety for the patient and makes possible a wider application of heart-lung bypass procedures.Most pump-oxygenation technics have a major disadvantage in that they require large volumes of blood for initial priming. Procurement of such quantities presents a difficult problem for the blood bank and the community. As more blood is administered in any given case, there is an increased risk in mismatching, reactions, as yet unexplained bleeding syndromes and late sequelae such . . .
¿SOMOS EFICACES EN EL TRATAMIENTO DE LAS ESTENOSIS ANASTOMÓTICAS EN LOS PACIENTES TRASPLANTADOS HEPÁTICOS?
Authors: C Padilla, A Ahumada, Ó Nogales, M López, G Pérez, A Caballero, C Gonzalez, J García, B Merino, P Menchén
Journal: Endoscopy (2014)

Introducción: La estenosis de la anastomosis biliar (EAB) es una complicación frecuente en el trasplante hepático (TH) que condiciona importante morbimortalidad. La CPRE es el tratamiento de elección. Sin embargo aún no se ha demostrado cuál es la estrategia de tratamiento óptima
Government is urged to commit resources to involve patients in NHS decisions
Authors: M. Limb
Journal: BMJ (2013)

Calls for greater influence of patients on the NHS are “just rhetoric” without concrete government plans to find, screen, and fund a new cadre of patient leaders, a conference has heard.

Ailsa Bosworth, chief executive of the National Rheumatoid Arthritis Society, said that it shouldn’t be left to charities alone to “fill the void” in training patients for such roles.

She said that the Francis inquiry into failings at Mid Staffordshire NHS Foundation Trust had not done enough to encourage patients to become leaders and that the government should start looking for them through a dedicated online “recruitment gateway.”

The …
ATRIAL FIBRILLATION ABLATION IMPROVES GLOBAL THROMBOTIC STATUS THROUGH ENDOGENOUS THROMBOLYSIS, AS EARLY AS 3 MONTHS POST ABLATION
Authors: Maria Niespialowska-Steuden, Vias Markides, Osita Okafor, Mohamed Farag, Nikolaos Spinthakis, Benjamin Artman, Diana A. Gorog
Journal: Journal of the American College of Cardiology (2015)
A Tight Predicament
Authors: An H. Bui, Patrick T. O'Gara, Katherine E. Economy, Amy Leigh Miller, Joseph Loscalzo
Journal: New England Journal of Medicine (2014)

A 27-year-old primigravid woman at 25 weeks 5 days of gestation presented to the emergency department in respiratory distress. One day earlier, a cough producing blood-tinged, frothy sputum had developed and worsened. She also noted shortness of breath and chest pain.
FRI0500 Daily practice of ultrasonography in 53 departments of rheumatology during 3 years follow up : the french experience
Authors: F. Gandjbakhch, F. Etchepare, S. Jousse-Joulin, C. Marcelli, J. P. Bertola, P. Bourgeois
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> The use of Ultrasonography (US) in rheumatology has considerably increased in the last few years. Evaluation of national osteoarticular US practice may lead to adapt trainings to increase standardization of US practice. <h3>Objectives</h3> To describe daily practice of US in French departments of rheumatology in a national multicentre longitudinal study of 3 years follow up. <h3>Methods</h3> Each year (T1, T2, T3), questionnaires were sent in order to collect informations concerning the experience of the centres in US practice and ultrasonographers' experience and practice use. Daily US practice was evaluated by collecting data (indication and results of US examinations) for all US examination performed during one month (September to October) each year. This evaluation was repeated during 3 years. <h3>Results</h3> During the 3 years follow up, the number of centres, of ultrasonographers and of US examinations performed per month increased considerably (table). Sonographers were young (mean: 37± 7,9 years) and have been practicing US for (mean) 4 years. 96% of them at T3 had a diploma for US practice (85% at T0) and 89% of them still participated to formations on US after their diploma. 64% used systematic examination for each pathology and 56 % used scoring systems. The 2398 US examinations per month at T3 were performed for inflammatory rheumatisms (60%), mechanical diseases (30%), other indications like Horton/PMR or Gougerot-Sjogren(10%). Concerning inflammatory rheumatism, US were mostly performed for rheumatoid arthritis (RA) (42%) (equally for diagnosis and follow up), for spondyloarthropathy (28%) (essentially for diagnosis) and for unclassified rheumatism (20%). RA examination was quite consensual among rheumatologists as more than 80% of the rheumatologists examined wrists, MCP 2 to 5, PIP 2 to 5 and MTP 2 to 5 for diagnosis and wrists, MCP 2 to 5 and MTP5 for follow up. Concerning Spondyloarthritis, there was no consensus for the joints to examine, but the examination of enthesis was homogeneous with more than 80 % of the rheumatologists practicing examination of the enthesis of lateral epicondyle tendon, patellar ligament, quadricipital tendon, calcaneum tendon and plantar aponevrosis. <h3>Conclusions</h3> This national multicentre longitudinal study demonstrated the widespread of US practice among the departments of rheumatology in France in a 3 years follow up. US examinations concerned mostly inflammatory diseases and appeared homogeneous among rheumatologists for RA and for SpA enthesis examinations. Yet, this study showed that only 56% of the rheumatologists used scoring systems and further training and formations should be necessary in order to improve standardization. <h3>Disclosure of Interest</h3> None Declared
RENAL VASCULAR CALCIFICATION AND RESPONSE TO RENAL NERVE DENERVATION IN LOWERING BLOOD PRESSURE
Authors: Arif Elvan, Annemiek Hoogerwaard, Mark de Jong, Ahmet Adiyaman, Jaap Jan Smit, Peter Delnoy, Jan-Evert Heeg, Boudewijn van Hasselt, Anand Ramdat Misier
Journal: Journal of the American College of Cardiology (2016)
Abstract 960: Use of MMTV-Neu/P53 KO transgenic mice to screen for potential chemopreventive agents
Authors: Ronald A. Lubet, Margaret Juliana, Kenneth Iwata, Clinton Grubbs
Journal: Cancer Research (2010)

Abstract The MMTV-Neu transgenic mouse develops Neu over-expressing ER− mammary cancers. Since human ER− Neu over-expressing mammary cancers often also have mutations in P53, a heterozygous KO of P53 was incorporated into the model. We have used this model to examine a wide variety of potential chemopreventive agents. The agents were routinely administered to virgin female MMTV-Neu/P53 KO mice beginning when they were 60 days of age. Initiation of treatment with the agents at this time is later than that often employed by other investigators (usually 35 days of age). Mice were routinely monitored until 360 days of age. It was found that both RXR agonists (Targretin, UAB-30) and EGFR 1 and/or 2 inhibitors (Tarceva, Lapatinib) were highly effective in preventing the development of these cancers. These results agree with previously published results by Dr. Powell Brown and colleagues. It was also observed that a wide variety of agents were ineffective; including Atorvastatin, rosiglitazone (a PPAR gamma agonist), SAHA (an HDAC inhibitor) and a soy isoflavones mixture. In separate studies, mice bearing small palpable mammary tumors were treated for five days with these various agents, and examined for alterations in potential biomarkers; including proliferation. As previously shown by our lab in an ER+ rat model of mammary cancer, effective agents (e.g., Iressa and Targretin) strongly inhibited cancer cell proliferation, whereas ineffective agents failed to significantly inhibit proliferation. Such a short-term assay might be employed to determine potential chemopreventive compounds. This model, therefore, appears useful in identifying agents that will prevent the development of breast cancer that over-express Neu. This is important since Neu over-expressing ER− cancers have a relatively poor prognosis, and Neu over-expressing ER+ tumors are relatively unresponsive to standard hormonal therapies (e.g., tamoxifen and aromatase inhibitors). Supported by NCI Contract Number HHSN261200433001C. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 960.
Ga-67 Imaging of Tumoral Calcinosis Associated With Secondary Hyperparathyroidism
Authors: GABRIEL SOUDRY, LEONARD P. CONNOLLY, S. T. TREVES
Journal: Clinical Nuclear Medicine (1996)

Tumoral calcinosis is a frequent manifestation of hyperparathyroidism secondary to chronic renal failure. Precipitates of hydroxyapatite crystals are deposited in subcutaneous tissue as lobulated masses. The authors present a case of Ga-67 uptake in the calcified soft tissue masses of a chronic renal failure patient. The abnormal Ga-67 localization may relate to either active calcification in these masses or an associated inflammatory reaction.
Abstract 2640: Risk of cytochrome P450 1B1 missense polymorphisms in renal cell carcinoma
Authors: Yuichiro Tanaka, Inik Chang, Shahana Majid, Sharanjot Saini, Mohd S. Zaman, Soichiro Yamamura, Takeshi Chiyomaru, Sumit Arora, Kamaldeep Singh, Varahram Shahryari, Angela V. Dahiya, Guoren Deng
Journal: Cancer Research (2012)

Abstract In male kidney, 4-hydroxy-estradiol has been shown to play a role in the carcinogenesis process. This metabolite is formed from estradiol and due to the hydroxylation activity of the cytochrome P450 1B1 (CYP1B1) enzyme. Prior reports show polymorphisms of CYP1B1 to result in higher catalytic activity and thus, we hypothesize that single nucleotide polymorphisms of the CYP1B1 gene are involved in the malignant transformation of the renal cell. To test this hypothesis, the genetic distributions of four missense CYP1B1 polymorphisms were analyzed in 383 normal healthy subjects and 384 sporadic renal cell carcinoma (RCC) cases by sequence-specific PCR and sequencing. All subjects were men and from a Caucasian population. The polymorphic sites evaluated were at codons 48 (ArgαGly, rs10012), 119 (AlaαSer, rs1056827), 432 (LeuαVal, rs1056836), and 453 (AsnαSer, rs1800440). Results of these experiments demonstrate a trend for the codon 119 Ser/Ser genotype to be a risk for RCC (χ2, P=0.09). Odds ratio for the Ser/Ser genotype was calculated as 1.85 with 95% confidence interval of 1.07-3.20 as compared to the Ala/Ala genotype. The Leu allele on codon 432 was also found to approach significance as a risk for RCC as compared to Val (χ2, P=0.09). Codons 119 and 432 were observed to be linked (R2=0.25) and haplotype analyses show Ala and Val, representing non-risk alleles at these sites, respectively, to be significantly reduced in RCC cases (P=0.06). No association was found however, when analyzing polymorphic sites with clinical stage of RCC. These results demonstrate missense polymorphisms of CYP1B1 to be associated with renal carcinogenesis and are of importance in understanding their role in the pathogenesis of RCC. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2640. doi:1538-7445.AM2012-2640
Observatoire multicentrique sur l'évaluation de la qualité de la préparation colique par association de picosulfate de Na et citrate de magnésium à du polyéthylène glycol à partir du logiciel EasyPP
Authors: G Bonnaud, J Lapuelle, D Reynaud, P Berry, A Ledit, JM Oliver, P Cabarrot
Journal: Endoscopy (2012)

Les préparations coliques évaluées dans le cadre des 2 jours d'endoscopies sont mauvaises dans 20 à 30%. Face à ces résultats insuffisants, la plupart des gastroentérologues utilisent des associations sans évaluation et hors AMM. Nous proposons une évaluation de l'association picosulfate de Na et citrate de magnésium, CITRAFLEET® à du polyéthylène glycol (PEG). La sécurité de cette association est motivée par l'absence de désordres hydroélectrolitiques induite par les PEG. La formule MOVICOL®sans arôme a été choisie afin de limiter l'impact sur la tolérance de la préparation et d'obtenir un moindre surcoût. Quatre sachets sont presque équivalents à un litre de PEG «classique».
L'échoendoscopie harmonique de contraste permet la différenciation histologique des tumeurs pancréatiques: intérêt de l'analyse de la courbe temps-intensité
Authors: E Bories, F Caillol, F Poizat, C Pesenti, M Giovannini
Journal: Endoscopy (2012)

L'échoendoscopie de contraste (CH-EUS) est supérieure à l'échoendoscopie-doppler standard pour décrire la microvascularisation tumorale. Ceci a été évalué essentiellement pour les masses pancréatiques avec une très bonne corrélation entre le type histologique et la présence ou non d'un rehaussement post injection. Plus récemment, à l'instar de l'échografie percutanée, il est possible d'utiliser l'échografie harmonique lors des échoendoscopies permettant une meilleure analyse de la microvascularisation et de déterminer des courbe temps-intensité (TIC). Le but de cette étude rétrospective était de corréler les différents types histologiques avec le niveau du signal obtenu après injection de produit de contraste.
Gastric volume reduction created by the articulating circular endoscopic stapler for the treatment of obesity – preliminary safety results
Authors: T Verlaan, EMH Mathus-Vliegen, EAML Veldhuyzen, JH Eshuis, P Fockens
Journal: Endoscopy (2012)

Objective: Dietary and medical treatment of obesity often fail. Surgical treatment is successful but carries considerable morbidity. Endoscopic treatment could be an alternative with less morbidity. A minimally invasive technique was developed and studied on an animal model. We now present the preliminary results of the first human trial of a gastric volume reduction created by the Articulating Circular Endoscopic Stapler (ACE) for the treatment of obesity. The aim of this study is to evaluate safety in terms of adverse events.
SAT0038 Factors Predicting Pain and Early Discontinuation of Tumour Necrosis Factor-Alpha-Inhibitors in People with Rheumatoid Arthritis: Results from the British Society for Rheumatology BIOLOGICS Register: Table 1:
Authors: D.F. Mcwilliams, D.A. Walsh
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Pain is a major problem in RA, but is not fully explained by inflammation. <h3>Objectives</h3> We investigated factors predicting bodily pain 1 year after initiation of anti-TNF or conventional DMARD therapy change in British Society for Rheumatology Biologics Register (BSRBR) participants with RA, and baseline patient-reported factors that predicted discontinuation of TNFα-inhibitors. <h3>Methods</h3> Data were retrieved from BSRBR-RA databases for baseline and up to 1 year after commencing TNFα-inhibitors (n=11995) or non-biologic DMARDs (n=3632). Norm-based SF36-Bodily Pain scores were used. DAS28-P was derived as the proportion of 28 joint disease activity score attributed to patient-reported factors. Adjusted odds ratios (aOR) using logistic regressions were calculated. <h3>Results</h3> Pain was severe at baseline (medians 25, 30) and incompletely improved during follow up (medians 34, 34 respectively) in TNF-inhibitor and control cohorts. Baseline pain was associated with DAS28-P, worse function, worse mental health, and higher DAS28. After logistic regression, independent significant predictors of worse than median pain at follow up after commencing either TNF-inhibitor or non-biologic DMARD were baseline pain, DAS28-P, worse function, worse mental health and co-morbidities. Older age, male gender, smoking and high BMI were additional predictors of worse pain outcomes in participants who received TNFα-inhibitors (Table 1). Some DMARDs were associated with better pain. Baseline pain predicted discontinuation of TNFα-inhibitors within the first year (aOR 1.13 (95% CI 1.05–1.22)); as did smoking (1.20 (1.06–1.36)), worse function (1.17 (1.08–1.26)), and systemic manifestations (1.15 (1.02–1.28)). <h3>Conclusions</h3> Pain may improve but remains a problem for people with treated RA. Worse pain outcomes are predicted by factors different to those typically used to predict inflammatory disease activity. Pain predicts treatment failure with TNFα-inhibitors. Improved pain management should complement inflammatory disease suppression in RA. <h3>Acknowledgements</h3> Funding: Pfizer Ltd. We would like to acknowledge the BSR Biologics Register for the collection, provision and preparation of the data used for this study. <h3>Disclosure of Interest</h3> D. Mcwilliams Grant/research support: Pfizer Ltd, D. Walsh Grant/research support: Pfizer Ltd <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.1549