tbuckley/cabot-search huggingface dataset:
Abstract P4-04-03: Targeting of phosphatidylserine by monoclonal antibodies augments the activity of immune checkpoint inhibitor PD-1/PD-L1 therapy in murine breast tumors
Authors: M Gray, J Gong, V Nguyen, J Hutchins, B Freimark
Journal: Cancer Research (2016)

Abstract Phosphatidylserine (PS) is a phospholipid that typically resides in the inner leaflet of the plasma membrane in many types of cells, including both tumor and tumor associated endothelial cells. Conditions that cause cellular stress, including those that occur from oxygen radicals, hypoxia, irradiation, and chemotherapy, cause a dramatic shift in PS localization. This change in localization results in PS shifting to the outer plasma membrane, allowing its recognition by components of the tumor microenvironment. Recognition of PS promotes an immunosuppressive environment that encourages tumor growth, in part by promoting the recruitment of myeloid derived suppressor cells, immature dendritic cells, and M2-like macrophages, in addition to inducing production of anti-inflammatory cytokines. Currently the chimeric PS-targeting antibody, bavituximab, is being used in combination with chemotherapies to treat patients with solid tumors in multiple late-stage clinical trials, where it is believe to help augment the efficacy of chemotherapeutics by blockade of PS-mediated immunosuppression and triggering an Fc-FcR mediated pro-inflammatory response in the tumor microenvironment. While the results with PS targeting therapies with chemotherapeutics are encouraging, the effectiveness of PS targeting therapies in conjunction with therapies towards immune checkpoint regulators remains largely unknown. To better understand the role of PS-targeting in breast cancers, and its effectiveness when used in combination with checkpoint inhibitors, immune competent mice harboring either EMT-6 or E0771 breast tumors were utilized. Treatments comprised PS targeting antibodies and an anti-PD1 antibody (to interrupt the PD-1/PD-L1 signaling axis) either alone or in combination with each other, and the effect on tumor growth and immune suppression determined. In both models, which showed differential sensitivity to therapy, the inclusion of PS targeting antibodies with the checkpoint blocker antibody had a significantly greater anti-tumor response than either single agent alone. Citation Format: Gray M, Gong J, Nguyen V, Hutchins J, Freimark B. Targeting of phosphatidylserine by monoclonal antibodies augments the activity of immune checkpoint inhibitor PD-1/PD-L1 therapy in murine breast tumors. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P4-04-03.
Long-Term Survival With Salvage Surgery for Recurrent Esophageal Adenocarcinoma After Chemoradiotherapy
Authors: Geoffrey Y. Ku, David H. Ilson
Journal: Journal of Clinical Oncology (2015)

Article Tools ONCOLOGY GRAND ROUNDS Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2015.62.6796 Journal of Clinical Oncology - published online before print August 31, 2015 PMID: 26324375 Long-Term Survival With Salvage Surgery for Recurrent Esophageal Adenocarcinoma After Chemoradiotherapy Geoffrey Y. KuxGeoffrey Y. KuSearch for articles by this author , David H. IlsonxDavid H. IlsonSearch for articles by this author Show More Memorial Sloan Kettering Cancer Center, New York, NY https://doi.org/10.1200/JCO.2015.62.6796 First Page Full Text PDF Figures and Tables © 2015 by American Society of Clinical Oncology
Grams
Authors: Charity Dean
Journal: JAMA (2003)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Abstract IA07: Systemic regulation of breast cancer progression
Authors: Sandra S. McAllister
Journal: Cancer Research (2016)

Abstract Recurrent disease affects approximately 30% of breast cancer patients but, unfortunately, by the time overt metastases are detected, it is no longer possible to treat breast cancer patients with curative intent. Clinical evidence indicates that in women who are diagnosed with metastatic breast cancer, tumor cells disseminate from the primary tumor prior to surgical resection but can remain indolent for varying periods of time before the patient becomes symptomatic. The reasons why certain disseminated cells remain indolent while others erupt into malignant tumors remain unknown; it is therefore currently difficult to predict with any degree of accuracy which patients will experience disease relapse. Our lab uses various mouse and xenograft models of breast cancer progression to study the early phases of metastatic disease when patients harbor indolent disseminated tumor cells in the periphery at the time of their primary diagnosis. Using triple-negative models, we previously showed that certain tumor systemically support the outgrowth of distant, otherwise indolent disseminated tumors, doing so by secreting cytokines into the host circulation and activating bone marrow hematopoietic cells to become pro-tumorigenic (McAllister, et al., Cell, 2008; Elkabets, et al., JCI, 2011; Castano, et al, Ca Disc, 2013). Using models of luminal breast cancer, we discovered that certain tumors promote the outgrowth of distant tumors by supporting angiogenesis (Kuznetsov, et al., Ca Disc, 2012). More recently, we have begun to identify the properties of disseminated tumor cells that are poised to respond to systemic factors and importantly, the phenotype of those that do not respond to systemic regulation. We have learned that certain systemic factors (cytokines and hematopoietic cells) elicited by primary breast tumors can sustain tumor-initiating properties of disseminated cells. Our findings highlight the systemic environment as an important component of disease progression that can be exploited to more accurately identify patients who would benefit from neoadjuvant or adjuvant therapy. Moreover, we hope that this work will pave the way to designing new therapies that can be delivered at a time when what has previously been an inexorable progression to terminal metastatic disease may be prevented. Citation Format: Sandra S. McAllister. Systemic regulation of breast cancer progression. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr IA07.
The Pathogenesis of Atherosclerosis
Authors: Russell Ross, John A. Glomset
Journal: New England Journal of Medicine (1976)

The Response-to-Injury HypothesisThe response-to-injury hypothesis dates back to the pioneering work of Virchow.120 Since then, it has been modified and extended by many investigators, including Duguid,121 French20 and Mustard and Packham,122 who play a particularly important part in its development. The basis for the hypothesis lies in the similarity between atherosclerosis and the response of arteries to experimental injury, described in the first part of this review. A modification of the hypothesis that takes into account many aspects of the behavior of arterial cells noted in that section is currently being studied in our laboratory. . . .
Natural history of male psychological health, XII: a 45-year study of predictors of successful aging at age 65
Authors: G E Vaillant, C O Vaillant
Journal: American Journal of Psychiatry (1990)

In order to determine important predictors of psychosocial and physical vitality in late midlife, the authors examined the lives of 173 men prospectively studied from ages 18 to 65. Biopsychosocial predictors--gathered before age 50--were examined for their correlation with three outcome variables measured at age 65: physical health, mental health, and life satisfaction. Extent of tranquilizer use before age 50 was the most powerful negative predictor of both mental and physical health outcomes at age 65. Another important predictor for mental health was maturity of defenses before age 50. Paradoxically, warm childhood environment made an important independent contribution to predicting physical--not mental--health.
Bipolar I, bipolar II, and nonbipolar major depression among the relatives of affectively ill probands
Authors: W Coryell, J Endicott, N Andreasen, M Keller
Journal: American Journal of Psychiatry (1985)

An earlier report described symptoms and background features in depressed probands grouped by polarity: bipolar I, bipolar II, and nonbipolar. The present study made similar comparisons among relatives with a lifetime history of major depression. The 73 relatives with bipolar II disorder had the highest rates of marital disruption, psychopathology in the previous month, nonserious suicide attempts, and nonaffective syndromes and were the youngest when first treated.
Management of pathologic stage IIIA Hodgkin's disease.
Authors: N E Sherman
Journal: Journal of Clinical Oncology (1985)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1985.3.6.884 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 4009221 Management of pathologic stage IIIA Hodgkin's disease. N E ShermanxN E ShermanSearch for articles by this author https://doi.org/10.1200/JCO.1985.3.6.884 PDF "Management of pathologic stage IIIA Hodgkin's disease.." Journal of Clinical Oncology, 3(6), pp. 884–885© 1985 by American Society of Clinical Oncology
Plasma lithium level and interepisode functioning in bipolar disorder
Authors: P J Goodnick, R R Fieve
Journal: American Journal of Psychiatry (1985)

There were no differences in interepisode functioning or side effects between bipolar patients (N = 44) with plasma lithium levels above the median and those with levels below the median. Low levels were able to stabilize mood and individual symptoms for 40.5 months.
DETECTION OF CLONALLY EXPANDED SALIVARY GLAND LYMPHOCYTES IN SJÖGREN'S SYNDROME
Authors: Bruce Freimark, Richard Fantozzi, Robert Bone, Gerald Bordin, Robert Fox
Journal: Arthritis & Rheumatology (1989)

Recurrent swelling of the parotid and submandibular salivary glands occurs in some patients with Sjögren's syndrome (SS). Using Southern blot methods, we analyzed immunoglobulin and T cell antigen receptor (TCAR) gene rearrangements in DNA obtained from salivary gland lymphocytes of 9 SS patients. Based on histologic appearance of the biopsy specimens, these patients were diagnosed as having myoepithelial sialadenitis. We found oligoclonal rearrangements of the kappa gene (4 patients) and lambda gene (1 patient), and oligoclonal rearrangement of the TCAR beta chain in 2 additional SS patients. Patients with Ig gene rearrangements did not show rearrangements of their TCAR gene, nor did patients with TCAR rearrangements exhibit Ig rearrangements. The observed oligoclonal rearrangements probably derive from 5-10% of the salivary gland B cells or T cells. Three of these SS patients developed non-Hodgkin's lymphoma 2-8 years after the initial biopsy. Our results suggest that minor populations of B cells or T cells may clonally expand in the salivary gland tissues of SS patients with pseudolymphoma, and that such lymphocyte expansions may be controlled by the endogenous immune response and/or medications. However, continued lymphoproliferation in these salivary gland tissues may eventually lead to emergence of a neoplastic clone that escapes immunologic control and develops into a non-Hodgkin's lymphoma as a result of a multistep process.
New outbreak of trichinellosis in the Midi-Pyrénées region of France, September-October 1998
Authors: C Hemery, S Haeghebaert
Journal: Eurosurveillance (1999)

Le 6 octobre 1998 onze cas de trichinellose survenus, en France, dans les departements de la Haute Garonne et du Tarn ont ete declares aux autorites sanitaires de la region Midi-Pyrenees. Les toutes premieres informations fournies par les medecins suggera
Postsurgical long-term survival.
Authors: M R Shetty
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.1.184 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2826713 Postsurgical long-term survival. M R ShettyxM R ShettySearch for articles by this author https://doi.org/10.1200/JCO.1988.6.1.184 PDF "Postsurgical long-term survival.." Journal of Clinical Oncology, 6(1), p. 184© 1988 by American Society of Clinical Oncology
Ifosfamide neurotoxicity in children.
Authors: S J Kellie, J Pritchard, A Bowman, J de Kraker, J S Lilleyman
Journal: Journal of Clinical Oncology (1987)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1987.5.3.512 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3819813 Ifosfamide neurotoxicity in children. S J KelliexS J KellieSearch for articles by this author , J PritchardxJ PritchardSearch for articles by this author , A BowmanxA BowmanSearch for articles by this author , J de KrakerxJ de KrakerSearch for articles by this author , J S LilleymanxJ S LilleymanSearch for articles by this author https://doi.org/10.1200/JCO.1987.5.3.512 First Page PDF © 1987 by American Society of Clinical Oncology
From supervisee to supervisor: an unexplored aspect of the psychiatrist's education
Authors: R B Granet, T P Kalman, M H Sacks
Journal: American Journal of Psychiatry (1980)

The authors describe several problems that are unique to the beginning supervisor of psychiatry residents. These difficulties can be divided into four general areas: inexperience, competition, identity, and administration. The authors provide examples to illustrate the types of situations that the new supervisor may encounter and make recommendations for dealing effectively with them.
Association of beta-endorphin with specific clinical symptoms of depression
Authors: D F Darko, S C Risch, J C Gillin, S Golshan
Journal: American Journal of Psychiatry (1992)

Abnormalities in plasma concentrations of beta-endorphin-like immunoreactivity (beta-endorphin) have been reported in depressed patients. This study was done to test the hypothesis that specific clinical characteristics of depression are associated with plasma beta-endorphin concentration.Plasma beta-endorphin was evaluated in 20 depressed patients diagnosed according to DSM-III-R and in 23 age- and sex-matched comparison subjects, and each was evaluated with the structured Schedule for Affective Disorders and Schizophrenia (SADS). Twelve SADS items involving dysphoric mood and related symptoms were chosen for analysis.Within the group of all 43 subjects and within the depressed group, beta-endorphin level correlated significantly with psychic anxiety and with phobia. In the depressed group only, beta-endorphin also correlated significantly with obsessions/compulsions. Concentration of beta-endorphin was not significantly correlated with score on the Hamilton Rating Scale for Depression or Beck Depression Inventory or with scores on other SADS symptom items, including somatic anxiety, insomnia, subjective anger, overt anger, agitation, psychomotor retardation, panic attacks, appetite loss, or total weight loss. In the group of 23 comparison subjects, beta-endorphin did not correlate with Beck or Hamilton depression score or with any of the SADS clinical variables.High levels of plasma beta-endorphin may be associated with more severe anxiety, phobia, and obsessions/compulsions in depressed patients.
Seasonal dynamics of bacterial meningitis: a time-series analysis
Authors: Juliette Paireau, Angelica Chen, Helene Broutin, Bryan Grenfell, Nicole E Basta
Journal: The Lancet Global Health (2016)

BackgroundBacterial meningitis, which is caused mainly by Neisseria meningitidis, Haemophilus influenzae, and Streptococcus pneumoniae, inflicts a substantial burden of disease worldwide. Yet, the temporal dynamics of this disease are poorly characterised and many questions remain about the ecology of the disease. We aimed to comprehensively assess seasonal trends in bacterial meningitis on a global scale.MethodsWe developed the first bacterial meningitis global database by compiling monthly incidence data as reported by country-level surveillance systems. Using country-level wavelet analysis, we identified whether a 12 month periodic component (annual seasonality) was detected in time-series that had at least 5 years of data with at least 40 cases reported per year. We estimated the mean timing of disease activity by computing the centre of gravity of the distribution of cases and investigated whether synchrony exists between the three pathogens responsible for most cases of bacterial meningitis.FindingsWe used country-level data from 66 countries, including from 47 countries outside the meningitis belt in sub-Saharan Africa. A persistent seasonality was detected in 49 (96%) of the 51 time-series from 38 countries eligible for inclusion in the wavelet analyses. The mean timing of disease activity had a latitudinal trend, with bacterial meningitis seasons peaking during the winter months in countries in both the northern and southern hemispheres. The three pathogens shared similar seasonality, but time-shifts differed slightly by country.InterpretationOur findings provide key insight into the seasonal dynamics of bacterial meningitis and add to knowledge about the global epidemiology of meningitis and the host, environment, and pathogen characteristics driving these patterns. Comprehensive understanding of global seasonal trends in meningitis could be used to design more effective prevention and control strategies.FundingPrinceton University Health Grand Challenge, US National Institutes of Health (NIH), NIH Fogarty International Center Research and Policy for Infectious Disease Dynamics programme (RAPIDD), Bill & Melinda Gates Foundation.
Economic downturns, universal health coverage, and cancer mortality in high-income and middle-income countries, 1990–2010: a longitudinal analysis
Authors: Mahiben Maruthappu, Johnathan Watkins, Aisyah Mohd Noor, Callum Williams, Raghib Ali, Richard Sullivan, Thomas Zeltner, Rifat Atun
Journal: The Lancet (2016)
Three case reports of acute paroxysmal excitement associated with alprazolam treatment
Authors: A Strahan, J Rosenthal, M Kaswan, A Winston
Journal: American Journal of Psychiatry (1985)

Three patients receiving alprazolam developed, within days after beginning treatment, acute excitatory states with features more suggestive of mania than of disinhibition syndrome. The authors suggest a neurochemical link between mania and disinhibitory states.
Merchant
Authors: M. Therese Southgate
Journal: JAMA (2007)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal