tbuckley/cabot-search huggingface dataset:
AB0826 Does Etanercept Influence Tweak Modulation of Inflammation During Psoriatic Arthritis?
Authors: S. Guis, P. Berbis, D. Stephan, N. Balandraud, N. Lesavre, N. Bonnet, S. Desplat-Jego
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> TWEAK (TNF weakly inducer of apoptosis) is a type II-transmembrane protein, member of the TNF ligand superfamily that can be cleaved to function as a soluble cytokine. Depending on target cell type and micro-environmental conditions, TWEAK triggers multiple cellular responses ranging from modulation of inflammation to cell death. Various data support that TWEAK produced by synovial macrophages may contribute to synovitis in human chronic inflammatory arthritis especially in psoriatic arthritis (PsoA). In PsoA, anti-TNF therapy has been successful in agreement with the key role of TNF in the pathogenesis of this disease and the generation by psoriatic patients of neutralizing anti-TNF autoantibodies referred as “beneficial autoimmunity to pro-inflammatory mediators”. However, the role of TNF-alpha in the regulation of TWEAK modulation of inflammation during PsoA remains unknown. <h3>Objectives</h3> To assess if anti-TNF therapy affects TWEAK modulation of inflammation during PsoA by evaluating if i) levels of serum soluble TWEAK and ii) levels of anti-TWEAK auto-antibodies generated by PsoA patients are influenced by etanercept therapy. <h3>Methods</h3> Serum samples from 13 patients with PsoA were collected before and at two time points during etanercept therapy (weeks 12 and 24). Serum samples of 53 healthy blood donors (HBD) were also collected and analyzed. Serum TWEAK concentrations were evaluated with a commercially available ELISA kit and circulating anti-TWEAK auto-antibodies were detected by a homemade-western blot. Disease activity was assessed according to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). <h3>Results</h3> Patients with PsoA had significantly higher serum levels of TWEAK compared with controls (respective Means (±SEM) were 645 pg/ml (64) and 467 pg/ml (23); (p=0.006)) but serum soluble TWEAK levels were not correlated with BASDAI (Spearman9s coefficients &lt;0.003, p&gt;0.05). Our study showed that soluble TWEAK levels were not modulated by etanercept therapy (respective Means (±SEM) were 645 pg/ml (64)(week 0), 605 (94) (week 12) and 744 (97) (week 24) pg/ml; (p&gt;0.23)). Anti-TWEAK autoantibodies were detected in 9/13 (69.2%) PsoA patients at inclusion and only in 3/53 (5.7%) HBD (p&lt;0.0001). These circulating antibodies were persistent in PsoA patients and detected at similar levels during etanercept therapy. <h3>Conclusions</h3> We showed here for the first time that during PsoA a significant elevation of TWEAK serum levels and a production of circulating anti-TWEAK autoantibodies occurred. Our data indicated that these two parameters were not significantly modified by anti-TNF therapy. <h3>Acknowledgements</h3> This work was supported by a grant by Pfizer (Pfizer WS 1797055). We thank Françoise Couranjou for her helpful contribution to this work. <h3>Disclosure of Interest</h3> None declared
Long-Term Survival in Malignant Melanoma With Special Reference to Age and Sex as Prognostic Factors&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: M Thörn, H O Adami, U Ringborg, R Bergström, U B Krusemo
Journal: JNCI Journal of the National Cancer Institute (1987)

A total of 12,353 (97.5%) of all patients with a first malignant melanoma newly diagnosed in Sweden during the period 1960-82 were subjected to a complete computerized follow-up with respect to survival through December 31, 1982. Calculation of relative survival rates (RSs) revealed a consistently more favorable course in women than in men, the 5-year RSs being 80.8 and 68.0% and the 10-year RSs being 75.0 and 61.8%, respectively. Prolonged follow-up and analyses of annual excess mortality showed, in addition, that men surviving about 10 years constituted an apparently cured fraction, whereas among women there was an excess mortality throughout the observation period. The prognosis was increasingly more favorable at younger ages in males, whereas no regular age trend emerged in the female group of patients. A multivariate analysis indicated that the findings were not confounded by temporal trends in RSs or by differences in tumor location between the groups compared and also that the relative hazard was significantly higher for men than for women only during the first 8 years after diagnosis.
AB0676 Sexual Dysfunction in Patients with Systemic Sclerosis
Authors: I. Uçar, O. Kucuksahin, M. Turgay, A. Ateş, G. Kınıklı, N. Düzgün
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Systemic Sclerosis (SSc) is a chronic autoimmune disease characterized by abnormal fibrotic processes, inflammation and microvascular damage. Changes associated with SSc such as skin tightening, muscle weakness, joint pain, deformity and decreased physical function can have a negative impact on female sexuality and sexual functioning <h3>Objectives</h3> We aimed to investigate the effect of systemic sclerosis on quality of life and sexual function in female patients. <h3>Methods</h3> Sexually active 30 female patients with SSc and 30 healthy control were included in the study. Female sexual index and SF-36 form filled out and detailed madical and sexual history was taken from both the control subjects and patients. <h3>Results</h3> The mean age of patients with SSc were 45,03±9,22 and the mean age of control group was 44,6±11,52. The age difference between study groups was not statistically significant. In patient group; 16 patients (%53,3) had dcSSc and 14 patients (%46,7) had lcSSc. 15 patients (%50) had pulmoner involvement. Thirthy patients (%100) were with ANA positive, 14 (%46,7) were with anti-Scl-70 antibody positive, 10 (%33,3) were with anti-centromer antibody positive. SF-36 scores in patient group was significantly lower than the control group (physical functioning (p=0,001), role-physical (p=0,0001), role-emotional (p=0,004), bodily pain (p=0,001), vitality (p=0,001), social functioning (p=0,03), mental health (p=0,0001), general health (p=0,0001)). Female sexual dysfunction was diagnosed in 26 of 30 (%86,6) SSc patient and 6 of 30 (%20) healthy control group. The difference was statically significant (p=0,0001). There was statistically significant difference betsen sexual desire (p=0.002), arousal (p=0.0001), lubrication (p=0.0001), orgasm (p=0.0001), satisfaction (p=0.0001) and pain (p=0,0001) domain scores. There was no statically significant relationship between disease subgroups, disease duration, pulmoner involvement and FSFI scores in patient group. <h3>Conclusions</h3> Sexual disfunction and lower health quality is a usual problem in female patients with systemic sclerosis <h3>References</h3> Schouffoer, A., et al., Impaired sexual function in women with systemic sclerosis: A cross-sectional study. Arthritis Care &amp; Research, 2009. 61(11): p. 1601-1608. <h3>Disclosure of Interest</h3> None declared
Diabetes Mellitus and Exercise
Authors: G L Landry, D B Allen
Journal: Diabetes Care (1995)

Physical exercise is traditionally considered beneficial in the treatment of IDDM. Attainment and maintenance of ideal body weight, improvement in self-image, and decreases in hypertension and lipid-related cardiovascular risk factors can all be achieved by the diabetic patient who exercises. Although the value of exercise in improving long-term glycemic control remains controversial, athletic participation by individuals with IDDM is encouraged to achieve the same health benefits enjoyed by exercising nondiabetic individuals. Knowledge of the metabolic responses to exercise in IDDM patients is required for appropriate guidance and management. Careful monitoring and adjustment of insulin doses and nutrition plans can then make possible the safe and successful participation of IDDM patients in virtually any athletic activity.
MULTIPLE PRIMARY CARCINOMA.
Authors: F T H'DOUBLER, A D VAIL
Journal: JAMA (1999)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Trazodone in depressed outpatients
Authors: K Rickels, W G Case
Journal: American Journal of Psychiatry (1982)

The authors compared the nontricyclic antidepressant trazodone with amitriptyline and placebo in a double-blind study of 202 unipolar depressed outpatients. Trazodone's clinical efficacy was similar to that of amitriptyline, with both active drugs producing significantly more clinical improvement than placebo. The incidence of anticholinergic side effects was lower for the patients taking trazodone than for those taking amitriptyline.
Expressed emotion and glucose control in insulin-dependent diabetes mellitus
Authors: H W Koenigsberg, E Klausner, D Pelino, P Rosnick, R Campbell
Journal: American Journal of Psychiatry (1993)

To clarify the meaning of the expressed emotion construct by testing its generalizability beyond psychiatric disorders, the authors measured family expressed emotion and glucose control in 35 diabetic patients. The critical comments component of expressed emotion significantly predicted glucose control, suggesting that the expressed emotion construct is not specific to psychiatric patients.
Prognostic impact of bone marrow fibrosis in primary myelofibrosis. A study of the AGIMM group on 490 patients
Authors: Paola Guglielmelli, Giada Rotunno, Annalisa Pacilli, Elisa Rumi, Vittorio Rosti, Federica Delaini, Margherita Maffioli, Tiziana Fanelli, Alessandro Pancrazzi, Lisa Pieri, Rajmonda Fjerza, Daniela Pietra, Daniela Cilloni, Emanuela Sant'Antonio, Silvia Salmoiraghi, Francesco Passamonti, Alessandro Rambaldi, Giovanni Barosi, Tiziano Barbui, Mario Cazzola, Alessandro M. Vannucchi
Journal: American Journal of Hematology (2016)

The prognostic significance of bone marrow (BM) fibrosis grade in patients with primary myelofibrosis (PMF) is still debated. A fibrosis grade greater than 1 was shown to associate with higher risk of death, and addition of fibrosis grade to IPSS score resulted in a more accurate prediction of survival. The aim of this study was to analyze the prognostic impact of BM fibrosis in 490 patients with PMF, evaluated at diagnosis, molecularly annotated and with extensive follow-up information. We found that fibrosis grade 2 and greater on a 0-3 scale was associated with clinical characteristics indicative of a more advanced disease, such as anemia, leukopenia, thrombocytopenia, constitutional symptoms, larger splenomegaly and a higher IPSS risk category. Patients with higher grade of fibrosis were also more likely to have additional somatic mutations in ASXL1 and EZH2, that are prognostically adverse. Median survival was significantly reduced in patients with grade 2 and 3 fibrosis as compared with grade 1; this effect was maintained when analysis was restricted to younger patients. In multivariate analysis, fibrosis grade independently predicted for survival regardless of IPSS variables and mutational status; the adverse impact of fibrosis was noticeable especially in lower IPSS risk categories. Overall, results indicate that higher grades of fibrosis correlate with unique clinical and molecular aspects and represent an independent adverse variable in patients with PMF; these observations deserve confirmation in prospectively designed series of patients. Am. J. Hematol. 91:918-922, 2016. © 2016 Wiley Periodicals, Inc.
Endoscopic ultrasound-guided drainage of a pancreatic fluid collection using a novel lumen-apposing metal stent complicated by stent occlusion
Authors: Pietro Capone, Maria Petrone, Emanuele Dabizzi, Alberto Mariani, Paolo Arcidiacono
Journal: Endoscopy (2016)

Endoscopic ultrasound (EUS)-guided transenteric drainage of pancreatic fluid collections (PFCs) is a well-established procedure. Recently a novel lumen-apposing, fully covered self-expanding metal stent (SEMS) has been developed to overcome the limitations of conventional SEMS for EUS-guided transenteric interventions [1] [2] [3].
THU0379 Dichotomy in FC Gamma Receptor IIB Deficiency and Autoimmune-Prone Slam Haplotype Reveals the Role of Slam Haplotype in Monocytosis and the Significant Effect of FC Gamma Receptor IIB Deficiency in Yaa-Related Lupus Nephritis
Authors: K. Nishikawa, Q. Lin, H. Tsurui, S. Kawano, K. Kojo, H. Amano, T. Shirai, S. Hirose
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> The inhibitory FcγRIIb-deficient mice develop autoimmune diseases, such as lupus nephritis, rheumatoid arthritis, and vasculitis with inflammatory cell infiltration [1,2]; however, the incorporation of FcγRIIb-linked autoimmune-prone SLAM haplotype in these gene targeting mice makes it difficult to isolate the role of FcγRIIb deficiency from SLAM haplotype in these diseases. <h3>Objectives</h3> In the present study, we genetically dissected the role of FcγRIIb deficiency and SLAM haplotype for these autoimmune diseases. <h3>Methods</h3> By extensively backcrossing 129-based FcγRIIb-deficient mice to B6 mice, three congenic mouse strains were established, the first with FcγRIIb deficiency and 129-derive autoimmune-prone SLAM haplotype (KO1), the second with FcγRIIb deficiency and B6 SLAM haplotype (KO2), and the third with wild-type FcγRIIb and 129 SLAM haplotype (SLAM<sup>129</sup>). <h3>Results</h3> Lupus nephritis did not develop in KO1, KO2, and SLAM<sup>129</sup>; however, KO1 and SLAM<sup>129</sup> showed age-associated monocytosis and perivascular inflammatory cell infiltration. When introducing <i>Yaa</i> mutation, KO1.<i>Yaa</i> and KO2.<i>Yaa</i> mice developed severe nephritis. In contrast, SLAM<sup>129</sup>.<i>Yaa</i> mice developed mild form of lupus nephritis with the increased serum level of IgM, but not IgG, class autoantibodies. <h3>Conclusions</h3> Monocytosis was shown to be one of the characteristic features in murine models of lupus nephritis [3]. Our study suggests that autoimmune-prone SLAM haplotype plays a pivotal role for monocytosis and resulting perivascular inflammatory cell infiltration; however, SLAM<sup>129</sup> alone is not enough for the development of lupus nephritis. FcγRIIb deficiency alone was not enough for both monocytosis and lupus nephritis. In the presence of <i>Yaa</i>, FcγRIIb deficiency plays a significant role for the development of lupus nephritis with isotype switch of autoantibodies from IgM to pathogenic IgG class. Mild form of lupus nephritis in SLAM<sup>129</sup>.<i>Yaa</i> mice may be due to the deposition of IgM autoantibodies in glomeruli, which results in the up-regulation of chemokine production by activated mesangial cells and resultant inflammatory cell infiltration to glomeruli because of the high frequencies of monocytes in periphery. <h3>References</h3> Bollans S. and Ravetch JV. Immunity 13:277-285, 2000. Sato-Hayashizaki A, et al. Arthritis Rheum. 63:2930-2938, 2011. Wofsy D, et al. J. Exp. Med. 159:629-634, 1984. <h3>Disclosure of Interest</h3> None declared
Two waves of pandemic influenza A(H1N1)2009 in Wales – the possible impact of media coverage on consultation rates, April – December 2009
Authors: M Keramarou, S Cottrell, M R Evans, C Moore, R E Stiff, C Elliott, D R Thomas, M Lyons, R L Salmon
Journal: Eurosurveillance (2011)

In the United Kingdom, the influenza A(H1N1)2009 pandemic had a distinct two-wave pattern of general practice consultations for influenza-like illness (ILI). We describe the epidemiology of the influenza pandemic in Wales between April and December 2009 using integrated data from a number of independent sources: GP surveillance, community virology surveillance, hospital admissions and deaths, and media enquiries monitoring. The first wave peaked in late July at 100 consultations per 100,000 general practice population and attracted intensive media coverage. The positivity rate for the A(H1N1)2009 influenza did not exceed 25% and only 44 hospitalisations and one death were recorded. By contrast, the second wave peaked in late October and although characterised by lower ILI consultation rates (65 consultations per 100,000 general practice population) and low profile media activity, was associated with much higher positivity rates for pandemic influenza A(H1N1)2009 (60%) and substantially more hospital admissions (n=379) and deaths (n=26). The large number of ILI-related consultations during the first wave in Wales probably reflected the intensive media activity rather than influenza virus circulating in the community. Data from community surveillance schemes may therefore have considerably overestimated the true incidence of influenza. This has implications for the future interpretation of ILI surveillance data and their use in policy making, and underlines the importance of using integrated epidemiological, virological and hospital surveillance data to monitor influenza activity.
Family influence in the recruitment of schizophrenic research subjects
Authors: R Ketai, R E Minter, M A Brandwin, M Brode
Journal: American Journal of Psychiatry (1981)

While seeking research subjects to test the effect of hemodialysis on schizophrenia, the authors noted that the relatives of schizophrenic patients tried to involve themselves excessively in the selection process. Of 27 patients referrals meeting diagnostic criteria for schizophrenia, only one contact was initiated by the patient; the rest were initiated by family members. In more than half of the family-initiated contacts relatives attempted to become excessively involved in the patient's decision making. The authors discuss these observations in light of family theories of schizophrenia. They urge caution in selecting subjects for research that attempts to test other researchers' earlier claims which may have stimulated premature hope of improvement.
Ventricular Excitation in Experimental Bundle-Branch Block
Authors: ROBERT V. ERICKSON, ALLEN M. SCHER, ROLFE A. BECKER
Journal: Circulation Research (1957)

Multipolar recording apparatus has been used to study the pattern of ventricular excitation in experimental bundle-branch block. After block, the wave of activation spreads uniformly from the contralateral ventricle across the septum to the free wall of the homolateral ventricle. Septal activation consumes more time than in the normal. Changes occur in the site and extent of early endocardial activity in the blocked ventricle. Alterations in both septal and mural depolarization contribute to QRS changes. Endocardial depolarization is described during recovery from transient bundle-branch block.
IMPAIRMENT OF THE ANTIGENICITY OF A PROTEIN ANTIGEN FOLLOWING ITS INJECTION INTO RABBITS
Authors: Philip D. McMaster, Joshua L. Edwards
Journal: The Journal of Experimental Medicine (1957)

The findings presented in this paper indicate that 60 gm. of liver tissue, taken from adult donor rabbits 2 weeks after injecting them with large amounts of bovine gamma-globulin, and transferred to the peritoneal cavities of recipient rabbits prepared for a secondary reaction, contain enough of the antigen to induce the formation of detectable amounts of precipitin in the recipient rabbits. On the other hand, liver taken from donors 21 and 28 days after injecting them with the same antigen fails to bring about a similar effect. The findings outlined in the paper suggest that the antigen is degraded after the 2nd week to such an extent that it fails to engender the formation of complete antibody in the recipient animals, although previous work has shown (2-4) that the transfer of liver tissue from similar donor rabbits to mice renders the recipient mice anaphylactically sensitive to the antigen, bovine gamma-globulin. The implications of the findings are discussed.
Sphingolipids As a Novel Target For The Treatment Of Multiple Myeloma
Authors: Jagadish Kummetha Venkata, Robert K Stuart, Luciano J Costa, Ningfei An, Houjian Cai, Woodrow J. Coker, Jin Song, Kiwana Gibbs, Terri Matson, Charles D Smith, Yubin Kang
Journal: Blood (2013)
&lt;italic&gt;Historical Note:&lt;/italic&gt; Roscoe Roy Spencer (1888–1982)
Authors: M B Shimkin
Journal: JNCI Journal of the National Cancer Institute (1984)

Journal Article Historical Note: Roscoe Roy Spencer (1888–1982) Get access Michael B. Shimkin Michael B. Shimkin Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 72, Issue 5, May 1984, Pages 969–971, https://doi.org/10.1093/jnci/72.5.969 Published: 01 May 1984 Article history Received: 19 December 1983 Accepted: 30 December 1983 Published: 01 May 1984
PWE-163 The changing demographic of the bariatric patient in the UK – the experience of a high through put bariatric unit: Abstract PWE-163 Table 1
Authors: JMH Bennett, W Carr, N Jennings, S Balupuri, K Mahawar, PK Small
Journal: Gut (2015)

<h3>Introduction</h3> With the publication of the 3 year NBSR results a key statement is the increasing age and weight of the average Bariatric surgical patient. This has been coupled with an increase in surgery for male patients across the UK. With this has come a larger burden of associated co-morbid conditions. We examined our bariatric practice to further consider this change. <h3>Method</h3> Analysis of a prospective database of all bariatric seminar attendances which includes demographic and weight data. Data is presented from 2008–2014. <h3>Results</h3> Overall we have seen an increase in attendance at our seminar and progression to surgery, tempered by the delay caused by the introduction of Tier 3 (Table 1). Over the 6 year period assessed the average BMI at both seminar and surgery has decreased. The proportion of the sexes has remained constant. A trend of increasing age at seminar and surgery is seen, although the increase is less in operated patients. The average BMI at surgery decreased from 52 to 49Kgm<sup>2</sup>for males but increased for women from 42 to 45 Kgm<sup>2</sup>. <h3>Conclusion</h3> Mean BMI has deceased for both male and female patients over time for both the seminar attendance and patients proceeding to surgery, contra to the data published by the NBSR. This may reflect a shift in the targeting of surgery in our centre towards patients with the maximum potential gain in terms of co-morbidity resolution and extended life span. It may also reflect a greater appreciation of the prevalence of morbid obesity and options for treatment leading to earlier referral from general practice. <h3>Disclosure of interest</h3> None Declared.