tbuckley/cabot-search huggingface dataset:
AB1241-HPR Static and Dynamic Pedobarographic Assessment in Patients with Juvenile Idiopathic Arthritis
Authors: S.N. Arman, E. Tarakci, O. Aydogan, K. Barut, O. Kasapcopur
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in childhood and adolescence and may generate short-term and long-term disability (1). The disease causes pain that may lead to posture and movement modifications and arouses muscular imbalance with reduced range of motion in the affected joints. Foot problems attributable to JIA include synovitis, tenosynovitis, enthesitis, pain, stiffness, and deformity (2). There is limited study about the foot impairments of patients with JIA. <h3>Objectives</h3> The aim of this study was to investigate foot problems of JIA patients with pedobarographic assessment. Pedobarography is an objective, functional method that could be used in the diagnosis and treatment of foot disorders. <h3>Methods</h3> 15 patients (10 female, 5 male) with JIA were enrolled in the study. Patients were included if they had a documented history of joint involvement affecting either two large lower limb joints, foot joint involvement or widespread polyarthritis as recorded by the physiotherapist. Plantar pressure assessment during walking and standing was used for Sensor Medica Pedobarographic System. Pedobarographic assessments as static (Forefoot loading, Rearfoot loading, Total loading, Maximum peak pressure - p.max) and dynamic (p. max, Loading in gait phases) were performed. <h3>Results</h3> Mean age was 12.26±3.62 years. Parameters of static and dynamic pedobarographic assessment are shown in Tables 1 and 2. It was found difference for almost all parameters between affected and unaffected lower extremity but this difference was not significant. Only, it was found significant difference for pressure rate in loading response phase. It was found difference for almost all duration of gait phases between affected and unaffected lower extremity but this difference was not significant. <h3>Conclusions</h3> Decreased duration of gait phases and impairment of plantar pressure distribution and was found in lower extremity affected patients with JIA in this study. Plantar pressure impairment and variation of duration in gait phases may cause increased energy consumption, fatigue and decreased functional ability in patient with JIA. We suggested that pedobarographic evaluation is important to reduce functional limitations and choose the appropriate orthosis in lower extremity affected patients with JIA. <h3>References</h3> Ravelli A, Martini A. Juvenile idiopathic arthritis. Lancet 2007;369:767–78. Hendry GJ, Turner DE, Lorgelly PK, Woodburn J. Room for improvement: patient, parent, and practitioners9 perceptions of foot problems and foot care in juvenile idiopathic arthritis.Arch Phys Med Rehabil. 2012 Nov;93(11):2062-7. <h3>Disclosure of Interest</h3> None declared
Correction: Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1
Authors: Jean-Sébastien Joyal, Ye Sun, Marin L Gantner, Zhuo Shao, Lucy P Evans, Nicholas Saba, Thomas Fredrick, Samuel Burnim, Jin Sung Kim, Gauri Patel, Aimee M Juan, Christian G Hurst, Colman J Hatton, Zhenghao Cui, Kerry A Pierce, Patrick Bherer, Edith Aguilar, Michael B Powner, Kristis Vevis, Michel Boisvert, Zhongjie Fu, Emile Levy, Marcus Fruttiger, Alan Packard, Flavio A Rezende, Bruno Maranda, Przemyslaw Sapieha, Jing Chen, Martin Friedlander, Clary B Clish, Lois E H Smith
Journal: Nature Medicine (2016)
A Novel Algorithm for Finding Interspersed Repeat Regions
Authors: Dongdong Li, Zhengzhi Wang, Qingshan Ni
Journal: Genomics Proteomics & Bioinformatics (2004)

Abstract The analysis of repeats in the DNA sequences is an important subject in bioinformatics. In this paper, we propose a novel projection-assemble algorithm to find unknown interspersed repeats in DNA sequences. The algorithm employs random projection algorithm to obtain a candidate fragment set, and exhaustive search algorithm to search each pair of fragments from the candidate fragment set to find potential linkage, and then assemble them together. The complexity of our projection-assemble algorithm is nearly linear to the length of the genome sequence, and its memory usage is limited by the hardware. We tested our algorithm with both simulated data and real biology data, and the results show that our projection-assemble algorithm is efficient. By means of this algorithm, we found an un-labeled repeat region that occurs five times in Escherichia coli genome, with its length more than 5,000 bp, and a mismatch probability less than 4%.
Sleep disorders in the elderly
Authors: M G Moran, T L Thompson, A S Nies
Journal: American Journal of Psychiatry (1988)

In their own practices and in consultation, requests to psychiatrists to evaluate and treat sleep disorders in the elderly are common. The five million elders in this country receive 35%-40% of the sedative-hypnotics prescribed, despite the fact that they represent only 12% of the population. Since their sleep disturbances are usually secondary to medical, psychiatric, pharmacologic, or environmental causes, they should receive a thorough evaluation and differential diagnostic approach. Before prescribing a sedative-hypnotic, one should consider nonpharmacologic interventions and education about normal sleep changes due to aging. As a foundation for the judicious prescribing of sedative-hypnotics, the pharmacokinetic changes associated with aging are discussed.
Cancer claims and registry data: A California linkage for quality measurement.
Authors: Dolores Yanagihara, Mahil Senathirajah, Marilyn Novich
Journal: Journal of Clinical Oncology (2016)

296 Background: Breast and colon are 2 of the most prevalent cancers in California according to the California Cancer Registry (CCR). Health claims data contains a wealth of information on diagnoses and treatment but lacks clinical information critical for evaluating care. Registry data contains key clinical information, but often does not contain the complete treatment regimen. This project aims to assess the feasibility of linking commercial claims data to population-based cancer registry data, and to use the linked data to examine variation in quality measures at the regional and physician organization (PO) levels. Methods: Nine NQF endorsed breast and colon cancer measures were selected and measure specifications with code sets were developed. Data on members identified with a diagnosis of breast and/or colon cancer in claims (2009-2012) from 4 commercial HMO health plans was linked with CCR data. Results were generated at the regional and PO levels. Results: The feasibility test was a success; CCR and claims data was linked for 8,757 individuals, and the data sets proved complementary. Rates relying on the linked dataset were typically higher than when either data source was used alone. For example, see the Table. Performance was strong across 8 of 9 measures with scores ranging from 80-98%. The 9 th measure, which relied only on CCR data, was 51%. PO level measurement was limited by small sample sizes, but where sample size was adequate, a significant amount of variation in performance across POs was found. Conclusions: The project showed that linkage of claims and registry data is feasible and that the linked dataset supports more robust assessment of the quality of cancer care. Further, the data dictionary and programmable code sets that were developed are available to other entities interested in creating linkages. With larger sample size, robust benchmarks could be established. Linked registry and claims data could be used for additional research in areas such as compliance with clinical guidelines and examining patterns of treatment. [Table: see text]
Value and Efficacy of Sentinel Lymph Node Diagnostics in Patients With Penile Carcinoma With Nonpalpable Inguinal Lymph Nodes
Authors: Ulf Lützen, Maaz Zuhayra, Marlies Marx, Yi Zhao, Stephanie Knüpfer, Christian Colberg, Klaus-Peter Jünemann, Carsten Maik Naumann
Journal: Clinical Nuclear Medicine (2016)

Purpose Sentinel lymph node biopsy (SLNB) has been described as a minimally invasive method for lymph node staging in patients with a penile carcinoma and nonpalpable inguinal nodes in national and international guidelines of involved professional societies. However, this method is rarely used. The aim of this study was to validate reliability and morbidity of this method and to discuss radiation exposure of persons involved. Methods Twenty-eight patients with histologically negative sentinel lymph nodes in 47 groins with nonpalpable inguinal lymph nodes were included in this study (17 T1(a/b)-, 8 T2- and 3 T3-stages). We recorded prospectively all cases of lymph node recurrence and complications in patients with initially nonpalpable inguinal lymph nodes and histologically negative sentinel lymph nodes. False-negative findings and morbidity were calculated as qualitative criteria. Inguinal regions with palpable lymph nodes and/or evidence of metastases were not considered in accordance with the guidelines. Results During a median follow-up of 68 (4–131) months, we observed one case of bilateral lymph node recurrence and one case of prolonged inguinal lymphorrhea, which could be managed conservatively. Per inguinal region, false-negative rate was 4.25%, and morbidity rate was 2.12%; seen per patient, the rates were both 3.57%. Conclusions Sentinel lymph node biopsy under use of radioactive tracers is a reliable method of lymph node staging in patients with penile carcinoma and nonpalpable inguinal lymph nodes. The methodical complexity is justified by high reliability and low radiation exposure for both patient and medical staff and low morbidity rates.
Multiple Sclerosis
Authors: Dale E. McFarlin, Henry F. McFarland
Journal: New England Journal of Medicine (1982)

(First of Two Parts)The lesions of multiple sclerosis were probably described as early as 1838,1 but it was Charcot in 18682 who recognized the characteristic clinical and pathologic features of the disease. Since that time, the disorder has been studied extensively. Numerous distinguished, even renowned physicians and scientists have investigated various aspects of multiple sclerosis. Although much has been learned and many theories have emerged, the cause and pathogenesis of this disease remains unknown. No preventive measures or definitive therapies exist. The purpose of this article is to review the classic clinical and pathologic aspects of the disease and . . .
Extension of remission in acute nonlymphocytic leukemia.
Authors: J P Dutcher, P H Wiernik
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.11.1783 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3054006 Extension of remission in acute nonlymphocytic leukemia. J P DutcherxJ P DutcherSearch for articles by this author , P H WiernikxP H WiernikSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.11.1783 PDF "Extension of remission in acute nonlymphocytic leukemia.." Journal of Clinical Oncology, 6(11), pp. 1783–1784© 1988 by American Society of Clinical Oncology
Soundings: This tablet may save your life
Authors: Trisha Greenhalgh
Journal: BMJ (2000)

A good way to sell a dubious product is to slap a label on it saying, “this could save your life.” If you surf the internet for long enough you can find such claims made for anything from megavitamins for the over 50s to gulp sized oxygen cylinders for stressed executives. What is extraordinary is that the claim is rarely made for drugs that could and do save lives.

A friend of mine recently telephoned in a panic on a Sunday morning. His mother had collapsed with central chest pain. The ambulance was on its way, but what could they do while waiting?

I asked some brief questions to confirm a likely heart attack, and gave some first aid advice, to which my friend was very receptive. Instructions to reposition the patient and loosen tight clothing were exactly what you might expect from a doctor in an emergency. I next quizzed him about contraindications to aspirin. He was surprised at these questions and needed to be told twice to seek the relevant information from his mother. There was a bottle in the bathroom cupboard, and I advised him to give her a single tablet.

“Look,” he said, “I don't think you understand what kind of pain she's in. Even two or three aspirin are not going to touch it. In any case it's probably better to wait till we get to hospital. I don't want to do anything until she's seen the doctor.”

The point of this story is that when the life of his nearest and dearest was hanging in the balance my friend was in no state to accommodate a lesson on the thrombolytic efficacy of low dose aspirin—a drug he still categorised as an old fashioned and rather dangerous painkiller.

My suggestion is simple: pharmaceutical companies should be encouraged to produce brightly packaged single dose aspirin tablets emblazoned with a red cross or other first aid symbol and the evidence based slogan, “This tablet could save your life if taken as soon as possible during a heart attack” along with a tick list of important contraindications.With a focused advertising campaign, the “miracle cure” will soon find its place next to the triangular sling in every family first aid kit. More importantly, patients and doctors can debate the potential benefits of such treatment at a time when their decision making faculties are appropriately tuned.
The alcoholic physician: a survey
Authors: L Bissell, R W Jones
Journal: American Journal of Psychiatry (1976)

The authors conducted interviews with 98 recovered alcoholic physicians, all of whom had been entirely abstinent for a minimum of one calendar year. Psychiatry was the only specialty clearly overrepresented. A disproportionate number of subjects reported high standing in their medical school classes. Nearly half of the sample had experienced difficulty with drugs other than alcohol. While legal sanctions and admission to health care and correctional institutions were common among this group, relatively little formal response of a disciplinary nature from colleagues or medical organizations was reported.
THU0477 Serum Levels of Resistin and Interleukin-17 are Associated with Increased Cartilage Defects and Bone Marrow Lesions in Patients with Knee Symptomatic Osteoarthritis
Authors: K. Wang, J. Xu, J. Cai, Z. Shuang, X. Yang, C. Ding
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Osteoarthritis (OA) is a disease characterized by a number of structural changes including cartilage loss and subchondral bone abnormalities. Metabolic triggered inflammation has been implicated in the pathogenesis of OA. Serum resistin levels increase with obesity in humans and the specific functions of resistin and IL-17 are still unknown in the development of knee OA. <h3>Objectives</h3> To investigate cross-sectional associations between serum levels of resistin and interleukin-17 and cartilage defects and bone marrow lesions in patients with knee symptomatic osteoarthritis (OA). <h3>Methods</h3> 194 randomly-selected patients with knee symptomatic OA (mean 55.4 years, range 34 to 74, 87% females) were included in Anhui Osteoarthritis (AHOA) Study. Knee cartilage defects and bone marrow lesions were determined at medial and lateral tibial, femoral and patellar sites using T2-weighted fat-suppressed fast spin echo MRI. Serum resistin and IL-17 levels were measured using ELISA. <h3>Results</h3> Serum resistin was positively associated with cartilage defects at lateral femoral (OR: 1.23, 95%CI 1.12 to 1.35), lateral tibial (OR: 1.14, 95%CI 1.04 to 1.24) and medial tibial (OR: 1.13, 95%CI 1.03 to 1.23) sites after adjustment for covariates. The significant associations were also present with bone marrow lesions at lateral femoral (OR: 1.19, 95%CI 1.09 to 1.30) and tibial sites (OR: 1.13, 95%CI 1.02 to 1.24) after adjustment for covariates. All these associations remained significant after further adjustment for IL-17. In patients with highest quartiles of hs-CRP (&gt;2.45 pg/ml), IL-17 was significantly associated with total cartilage defect score (r=0.267, p=0.001) and cartilage defects at nearly all sites (except for medial tibial) after adjustment for covariates. These significant associations decreased in magnitude and became non significant at medial femoral, lateral tibial and patellar sites after further adjustment for resistin. Similarly, IL-17 was significantly associated with BMLs at lateral and medial femoral sites after adjustment for covariates, and the association at lateral femoral site became non significant after further adjustment for resistin. <h3>Conclusions</h3> Serum levels of resistin are independently and consistently associated with cartilage defects and BMLs in patients with knee OA. In addition, the associations of serum IL-17 with cartilage defects and BMLs in patients with a higher inflammatory status are largely mediated by resistin suggesting resistin may play a key role in cartilage loss and bone abnormalities in patients with knee OA. <h3>Disclosure of Interest</h3> None declared
18F-FDG PET/CT in a Patient With Glomus Vagale Paraganglioma and Eisenmenger Syndrome
Authors: Charlie Chia-Tsong Hsu, Dalveer Singh, Gigi Nga Chi Kwan, Sandeep Bhuta
Journal: Clinical Nuclear Medicine (2015)

There is emerging evidence linking cyanotic heart disease and pheochromocytoma-paraganglioma through a proposed hypoxia pathway. We present a 59-year-old woman with known Eisenmenger syndrome secondary to delayed diagnosis of ventricular septal defect, in whom F-FDG PET/CT provided comprehensive evaluation of both an F-FDG-avid left glomus vagale paraganglioma and also increased right ventricular myocardial glucose metabolism in response to severe pulmonary hypertension in the chronic shunting state.
Wernicke's Encephalopathy
Authors: M C Lindberg, R A Oyler
Journal: New England Journal of Medicine (1985)

Wernicke's encephalopathy should be considered as a possible diagnosis in comatose and hypothermic patients. The classic triad of confusion, ophthalmoplegia (or nystagmus) and ataxia may be absent, and the history of alcohol abuse or other causes of thiamine deficiency may be unknown. Left untreated, acute Wernicke's encephalopathy has a 17 percent mortality rate. Since the morbidity from Wernicke's encephalopathy is potentially reversible with parenteral thiamine, and large doses of thiamine can be given without documented ill effects, it is recommended that all comatose or hypothermic patients, as well as those with more classic presentations of Wernicke's encephalopathy, be given parenteral thiamine before administration of glucose.
AB1058 Echocardiographic and Humoral Parametres in Systemic Sclerosis and MCTD in Relation to Pulmonary Hypertension
Authors: J. Vymetal, A. Smrzova, M. Hutyra, P. Horak, M. Skacelova, K. Langova
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Echocardiography at our department is performed routinely in all patients with connective tissue diseases, where a suspicion or diagnosis of pulmonary hypertension is found by screening in lower percentage of patients only. <h3>Objectives</h3> The aim of our study is to evaluate the importance of deformation analysis of right vectricle free wall using 2D strain by speckle trackinkg and other parametres of systolic function of the right ventricle (fractional area change, FAC) from the point of view of their predictive potential for early phase pulmonary hypertension detection in patient with systemic sclerosis and related diseases. <h3>Methods</h3> From april 2013 to september 2014 we examined by echocardiography total 74 patients, 63 patients with systemic sclerosis and 11 patients with mixed connective tissue disesase. Except routine left and right ventricle assessment and pulmonary pressure estimation, the FAC of the right ventricle and 2D strain of right ventricle free wall were evaluated and further NT-proBNP, Troponin T were measured. In addition all patients had determined DLCO and selected patients underwent right heart catheterization. Measured parametres were correlated and their predictive potential was calculated. <h3>Results</h3> Pulmonary hypertension (PH) was found as unlikely in 59 patients (79,7%), possible in 10 patients (13,5%) and probable in 5 patient (6,7%). Statistical significant relation was found for PASP and RV free wall middle segment strain (rs =0,292, p=0,012), for PASP and NT-proBNP (rs =0,436 p=0,001) and further for PASP and FAC (rs 0,320, p 0,005). No correlation of pulmonary artery pressure with left ventricle sytolic function parametres was found in these patients. <h3>Conclusions</h3> Presence of pulmonary hypertension is important finding influencing prognosis in patient with systemic sclerosis and related diseases and active search for PH is necessary to select patient indicated to invasive investigation an possible specific treatment. <h3>References</h3> Lefèvre G, Dauchet L, Hachulla E et al. Survival and prognostic factors in systemic sclerosis -associated pulmonary hypertension: a systematic review and meta-analysis. Arthritis Rheum. 2013 Sep; 65(9):2412-23. Rudski LG, Lai WW, Afilalo J, et al. Guidelines for the echocardiographic assessment of the right heart in adults: a report from the American Society of Echocardiography endorsed by the European Association of Echocardiography, a registered branch of the European Society of Cardiology, and the Canadian Society of Echocardiography. J Am Soc Echocardiogr. 2010;23(7):685-713. Spethmann S, Dreger H, Schattke S et al. Two-dimensional speckle tracking of the left ventricle in patients with systemic sclerosis for an early detection of myocardial involvement. Eur Heart J Cardiovasc Imaging. 2012 Oct;13(10):863-870. <h3>Disclosure of Interest</h3> None declared
First joint meeting of three European tuberculosis networks
Authors: M J van der Werf, C Erkens, A Gebhard, F Voitzwinkler, M Dara
Journal: Eurosurveillance (2013)

On 29 May 2013 three European tuberculosis (TB) networks met for the first time to discuss TB prevention, control and care in the World Health Organization (WHO) European Region including the European Union (EU). This meeting, which took place in The Hague, the Netherlands, provided a unique opportunity to discuss progress with the implementation of the Berlin Declaration on TB [1], the European Centre for Disease Prevention and Control (ECDC) Framework Action Plan to fight tuberculosis in the EU [2,3], and the Consolidated Action Plan to prevent and combat multidrug- and extensively drug-resistant tuberculosis (M/XDR-TB) in the WHO European Region [4]. Surveillance focal points, laboratory experts, and National TB Programme Managers (NTPs) exchanged lessons learned and discussed next steps to reach the targets defined in the plans.
Late Breaking News: NIH Appropriations Bills Moving Through House, Senate
Authors: C. Vanchieri
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Late Breaking News: NIH Appropriations Bills Moving Through House, Senate Get access Cori Vanchieri Cori Vanchieri Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 15, 7 August 1991, Page 1059, https://doi.org/10.1093/jnci/83.15.1059 Published: 07 August 1991
Cytotoxic T Lymphocyte Antigen 4 (CTLA4) Single Nucleotide Polymorphisms Do Not Impact Outcomes After Unrelated Donor Transplant: A Center For International Blood and Marrow Transplant Research Analysis
Authors: Tao Wang, Stephanie J. Lee, Michael D. Haagenson, Stephen Spellman, Mbs, Marcelo A. Fernandez Viña, Carlheinz R. Muller, Michael R. Verneris, Bipin N. Savani, Madan Jagasia
Journal: Blood (2013)