tbuckley/cabot-search huggingface dataset:
PWE-104 The Financial Impact Of A Nurse-led Ibd (inflammatory Bowel Disease) Telephone Advice Service, In A Large District General Hospital
Authors: S Squires, A Boal, G Naismith
Journal: Gut (2014)

<h3>Introduction</h3> It has become increasingly recognised that outpatient management is more cost effective in IBD.<sup>1</sup> IBD Standards (Revised 2013) recommend telephone advice for patients with regards to symptoms and medication management. This report attempts to quantify the net financial impact of this service at our hospital since it was introduced in August 2013. <h3>Methods</h3> The Royal Alexandra Hospital in Paisley is a District General Hospital with a catchment population of 200,000<sup>2</sup> with approximately 2500 IBD patients. Data relating to the use of the Telephone Advice service was prospectively recorded on a daily basis for a period of 5 months. We Documented reasons for calling and the likely action taken by the patient had the telephone advice line not been available. Cost savings based on alternative outcomes were made in accordance the Department of health figures.<sup>3</sup> <h3>Results</h3> The mean calls per month was was 88 [IQR 24] – (Mean calls which were deemed Non-IBD issues was, was 30 calls per month [IQR 8.0]) The mean cost of staffing the IBD advice line with an IBD Clinical Nurse Specialist was £482.00 per month [IQR 195.5]. The mean time spent on calls per month was 28.5 h [IQR 11.5]. Cost Savings over 5 months for avoidance of GP consultation was £3408.00. Savings for avoidance of a consultant appointment made over the 5 month period was £27454.00. Savings made from patients avoiding either an A+E or Hospital Admission were £540.00 and £11488.00 respectively over the 5 month period. The net saving was £42890.00. <h3>Conclusion</h3> A Nurse-Led telephone advice line appears to be a cost effective intervention. It may prevent patients from unnecessary hospital attendance. Savings can be made to both primary and secondary care. Overall, it appears that the advice line is providing a highly valuable service, not just in terms of accessible treatment decisions and guidance for patients, but cost savings when Specialist Nurse time is compared to General Practitioners, Consultants or hospital facilities. <h3>References</h3> Park KT, Bass D. Inflammatory bowel disease‐attributable costs and cost‐effective strategies in the United States: A review. <i>Inflammatory Bowel Diseases, </i>2011 – Wiley Online Library NHSGGC (National Health Service, Greater Glasgow and Clyde) – Consultation document 2006-2012 http://www.nhsggc.org.uk Department of Health reference Costs 2011–2012 https://www.gov.uk <h3>Disclosure of Interest</h3> None Declared.
Abstract 617: Small molecule that simultaneously inhibits Myc oncoprotein and activates HIF1A
Authors: Chengyuan Xue, Leanna Cheung, Murray D. Norris, Michelle Haber, Catherine Burkhart, Natalia Fedtsova, Andrei Gudkov, Sergei S. Makarov
Journal: Cancer Research (2011)

Abstract Aberrant expression of Myc oncoproteins is a major causal factor in a large proportion of human cancer. In particular, MYCN oncogene amplification is one of the most powerful prognostic markers identified in the childhood cancer neuroblastoma and, as such, represents a valuable therapeutic target for the development of novel treatment approaches. A diverse chemical library of small molecules was screened using a cell-based assay to identify inhibitors of MYCN. Among a number of molecules identified as potential Myc inhibitors, M606 was found to reduce protein expression of MYCN and its downstream target genes in the MYCN-amplified neuroblastoma cell line BE(2)-C. A similar effect was also observed in a number of c-Myc over-expressing tumor cell lines. Analysis of signalling pathways affected by M606 using FACTORIAL™ technology (Attagene Inc.) indicated that this small molecule inhibited Myc mediated transcription in a dose-dependent manner. Interestingly, hypoxia inducible factor 1 alpha (HIF1A) was induced ∼100 fold. Consistently, we observed HIF1A protein accumulation and nuclear translocation post-M606 treatment under normoxic conditions accompanied by activation of transcription of the HIF1A target, VEGF. siRNA-mediated knockdown of c-Myc or HIF1A in HepG2 cells followed by M606 treatment demonstrated that downregulation of c-Myc and upregulation of HIF1A by M606 are two independent events. Furthermore, inhibition of HIF1A prolyl hydroxylases by dimethyloxalylglycine (DMOG) resulted in downregulation of c-Myc protein independent of any HIFA upregulation. These results suggest that the same molecular mechanism, targeted by M606 and presumably involving inhibition of prolyl hydroxylases, can affect both HIF1A and Myc but in opposite ways. Further development of this compound may be useful in the treatment of cancers in which Myc oncoproteins are overexpressed as well as in the treatment or prevention of ischemic injury since recent studies suggest HIF1A activation may protect against ischemia-reperfusion injury. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 617. doi:10.1158/1538-7445.AM2011-617
Pose de prothèse métallique expansive dans le cancer colorectal en occlusion: résultats d'une série prospective monocentrique
Authors: A Attar, A Nuzzo, M Ferron, F Bretagnol, Y Bouhnik, Y Panis
Journal: Endoscopy (2012)

La pose de prothèse métallique expansive est utilisée pour lever l'occlusion en cas de cancer colique ou rectal mais avec des résultats controversés à long terme.
Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer
Authors: Stephan Braun, Klaus Pantel, Peter Müller, Wolfgang Janni, Florian Hepp, Christina R.M. Kentenich, Stephan Gastroph, Artur Wischnik, Thomas Dimpfl, Günter Kindermann, Gert Riethmüller, Günter Schlimok
Journal: New England Journal of Medicine (2000)

Cytokeratins are specific markers of epithelial cancer cells in bone marrow. We assessed the influence of cytokeratin-positive micrometastases in the bone marrow on the prognosis of women with breast cancer.
Treatment of Cushing's Disease
Authors: T. Eugene Temple, Douglas J. Jones, Grant W. Liddle, Richard N. Dexter
Journal: New England Journal of Medicine (1969)

In four patients with Cushing's disease given the adrenocorticolytic agent o,p′DDD, the therapeutic objective of reducing cortisol secretion without producing aldosterone deficiency was achieved after several months of treatment. To avoid gastrointestinal intolerance, low doses (about 3 gm per day) were used. Patients with subnormal plasma 17-hydroxycorticosteroids were given dexamethasone, 0.5 mg daily, as a safeguard against glucocorticoid deficiency. Aldosterone secretion rates were normal or slightly elevated, and the patients adapted to sodium deprivation with virtually complete renal conservation of sodium. Electron microscopy revealed degenerative changes in the mitochondria of the zona fasciculata, with sparing of the zona glomerulosa. Plasma ACTH concentrations were originally elevated and remained so. Adrenal responsiveness to the infusion of ACTH was greatly reduced.
Relationship Between Serious Wheat Allergy Caused By Cutaneous Sensitization and Mutations in the Filaggrin Gene
Authors: Akiko Yagami, Emiko Noguchi, Mayumi Tamari, Tomomitsu Hirota, Zenichiro Kato, Hirohisa Saito, Kayoko Matsunaga
Journal: Journal of Allergy and Clinical Immunology (2016)
Lysyl oxidase-like 2 promoter hypermethylation in mid-dermal elastolysis
Authors: T. Gambichler, M. Skrygan, L. Reininghaus, H.-J. Schulze, J. Schaller, S. Hessam, C. Colato, G. Girolomoni, E. Heitzer
Journal: British Journal of Dermatology (2016)
Familial Recurring Polyserositis Simulating Acute Surgical Condition of the Abdomen
Authors: Robert K. Nixon, Robert J. Priest
Journal: New England Journal of Medicine (1960)

VARIOUS designations have been given to a disease of unknown etiology characterized by recurring acute inflammation of single or multiple serous membranes, usually accompanied by fever and limited almost exclusively to people of Armenian, Jewish or Arab origin. Because of the predominant occurrence of abdominal findings, the condition has been termed "benign paroxysmal peritonitis" by Siegal1 , 2 and "periodic peritonitis" by Reimann et al.3 Reports in the French literature have appeared under the title "La Maladie Periodique"4 5 6 7 8 9 10 11 12 13 and more recently Heller, Sohar and Sherf14 have introduced the term "familial Mediterranean fever." In Lebanon the disease is referred to as "Armenian disease." . . .
DIFFERENTIAL REGULATION OF INFLAMMATORY ADHESION MOLECULES DURING ENDOTHELIAL REGENERATION AFTER PERMANENT VERSUS BIORESORBABLE POLYMER DES IMPLANTATION
Authors: Hiroyoshi Mori, Kazuyuki Yahagi, Tobias Koppara, Oscar Sanchez, Frank Kolodgie, Qi Cheng, Eduardo Acampado, Renu Virmani, Michael Joner
Journal: Journal of the American College of Cardiology (2015)
Benign Intrapulmonary Schwannoma
Authors: Michel Gonzalez, John O Prior, Samuel Rotman, Hans-Beat Ris, Thorsten Krueger
Journal: Clinical Nuclear Medicine (2011)

A 75-year-old man, with no significant symptoms, was referred after the incidental finding of a left hilar pulmonary mass of 30 × 30 × 50 mm on a chest CT. F-18 fluorodeoxyglucose (FDG) PET/CT demonstrated a heterogeneous, moderate radiotracer uptake in the mass (SUV 3.5 g/mL). Bronchoscopy revealed a discrete extrinsic compression of the superior bronchus without endobronchial lesion. Endobronchial fine-needle biopsies could not deliver a final diagnosis. The patient underwent upper lobectomy by thoracotomy. Histopathology revealed a benign intrapulmonary schwannoma. Although rare, intermediate FDG uptake in the settings of a pulmonary mass should include schwannoma in the differential diagnosis.
CNS Vasculitis in Systemic Lupus Erythematosus Complicated by Antiphospholipid Antibody Syndrome: Temporal Evaluation of Stroke by Repeated Tc-99m HMPAO SPECT
Authors: ELMER C. SAN PEDRO, JAMES M. MOUNTZ
Journal: Clinical Nuclear Medicine (1998)

A unique case is presented of a 39-year-old woman with systemic lupus erythematosus (SLE) complicated by antiphospholipid antibody syndrome who had two cerebral infarctions during a 2-week period. She was admitted because of a left-sided hemiparesis and visual disturbance. Tc-99m HMPAO brain SPECT scans showed the diversity of stages in infarction as demonstrated by regional cerebral blood flow perfusion defects and luxury perfusion. Cerebral angiogram revealed a classic "beading" pattern consistent with vasculitis. CT scan evaluation showed the cerebral infarctions that were identifiedon SPECT. Tc-99m HMPAO SPECT was able to show multiple sequential infarctions characteristic of antiphospholipid antibody syndrome.
Abstract 1650: CYC065, a novel CDK2/5/9 inhibitor: detailed mechanistic studies, determinants of sensitivity and synergistic combinations
Authors: Chiara Saladino, Sheelagh Frame, Susan Davis, David Blake, Daniella Zheleva
Journal: Cancer Research (2015)

Abstract Background: CYC065 is a novel, second generation aminopurine inhibitor highly selective for CDK2, CDK5 and CDK9 over other CDKs and non-CDK enzymes. CYC065 has completed IND-directed drug development and is ready for FIH studies. The unique target profile of CYC065 can be exploited in cyclin E-overexpressing tumors, including a trastuzumab-resistant Her2+ breast cancer model (Scaltriti et al, PNAS 2011; 9:3761). The aim of this study was to gather key dosing information for this compound in advance of FIH studies, and provide understanding of the compound mechanism of action in additional key target indications. CDK9 is a key regulator of mixed lineage leukemia (MLL)-driven leukemogenesis and Mcl-1-dependent survival and therefore represents a potential therapeutic target for AML and MLL leukaemia. Methods: A panel of acute leukemia cell lines with different MLL status (WT, MLL translocations and MLL PTD) was used in this study. Resazurin and flow cytometry-based annexin V assays were used to determine cell viability and apoptosis induction. PI staining was used to examine cell cycle distribution. Protein levels were quantified by Western blotting and quantitative imaging. Combinations were studied using the Chou and Talalay method. The in vivo activity of CYC065 was studied in murine xenograft models. Results: CYC065 rapidly decreased phosphorylation of Ser2 -RNAP II and expression of proteins involved in cell cycle control, survival and leukemogenesis (such as Mcl-1, Cyclin E, PNUTS, Hoxa9 and Meis 1), leading to robust and early induction of apoptosis (within 4 h). Time- and dose-dependent studies indicated that 6 h pulse treatment at 0.5-1 μM CYC065 was sufficient to cause ≥ 90% cell death in sensitive cell lines. Cell lines with MLL rearrangements were highly sensitive to CYC065, whilst sensitivity of AML cell lines with WT MLL correlated with the level of Bcl-2 family proteins. Cell lines with reduced sensitivity to CYC065 could be effectively targeted by exposure to longer, 10 h pulse treatments with CYC065, or in combination with short pulses of Bcl-2 inhibitors. In vivo, CYC065 achieved &amp;gt;90% TGI at well tolerated dose levels in HL60 (WT MLL) and EOL-1 (MLL PTD) xenograft models. Conclusion: CYC065 has therapeutic potential for AML and MLL leukemia. MLL status and the levels of Bcl-2 family proteins might be useful patient stratification markers for predicting sensitivity/resistance. Citation Format: Chiara Saladino, Sheelagh Frame, Susan Davis, David Blake, Daniella Zheleva. CYC065, a novel CDK2/5/9 inhibitor: detailed mechanistic studies, determinants of sensitivity and synergistic combinations. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1650. doi:10.1158/1538-7445.AM2015-1650
Adenoviral Vectors with E1A Regulated by Tumor-Specific Promoters Are Selectively Cytolytic for Breast Cancer and Melanoma
Authors: Lixin Zhang, Hakan Akbulut, Yucheng Tang, Xueyuan Peng, Giuseppe Pizzorno, Eva Sapi, Sebastian Manegold, Albert Deisseroth
Journal: Molecular Therapy (2002)

We have previously demonstrated that a truncated form of the L-plastin promoter can confer tumor-specific patterns of expression on replication-incompetent adenoviral vector reporter and therapeutic transcription units. In this report, a 2.5-kb truncated version of the L-plastin promoter was placed 5′ to the E1A gene of a wild-type adenovirus. The vector generated (Ad-Lp-E1A) was directly cytotoxic to established breast and ovarian cancer cell lines and to primary explant cultures derived from ovarian cancer, but was not cytotoxic to explant cultures of normal mammary epithelial cells. This vector was not cytotoxic to cell lines in which the L-plastin E1A transcription unit was not expressed, whereas the same cell lines were sensitive to the cytotoxic effect of a replication-competent adenoviral vector in which the cytomegalovirus (CMV) promoter drove E1A expression. When the tyrosinase promoter/enhancer was placed 5′ to the E1A gene in the adenoviral backbone, the resulting vector (Ad-Tyr-E1A) was selectively toxic to melanoma cells and one percent as toxic to explants of ovarian cancer cells as the Ad-Lp-E1A vector. Injection of these vectors (Ad-Lp-E1A and Ad-Tyr-E1A) into nodules derived from the MCF-7 and MDA-MB-468 human breast cancer cell lines and the TF-2 human melanoma cell line, respectively, which were growing subcutaneously in severe combined immunodeficiency (SCID) mice, induced regression of these tumors. Such vectors may therefore be useful in cancer treatment.
A case study in innovative outreach--combining training, research, and technology transfer to address real-world problems.
Authors: D P Chang
Journal: Environmental Health Perspectives (1998)

Outreach, training, technology transfer, and research are often treated as programmatically distinct activities. The interdisciplinary and applied aspects of the Superfund Basic Research Program offer an opportunity to explore different models. A case study is presented that describes a collaborative outreach effort that combines all of the above. It involves the University of California's Davis and Berkeley program projects, the University of California Systemwide Toxic Substances Research and Teaching Program, the U.S. Navy's civilian workforce at the former Mare Island Naval Shipyard, Vallejo, California (MINSY), a Department of Defense (DoD) Environmental Education Demonstration Grant program, and the Private Industry Council of Napa and Sonoma counties in California. The effort applied a Superfund-developed technology to a combined waste, radium and polychlorinated biphenyl contamination, stemming from a problematic removal action at an installation/restoration site at MINSY. The effort demonstrates that opportunities for similar collaborations are possible at DoD installations.
Complexing of amino acids to DNA by chromate in intact cells.
Authors: V Voitkun, A Zhitkovich, M Costa
Journal: Environmental Health Perspectives (1994)

Using o-pthaldialdehyde (OPT) fluorescence, the amino acids associated with DNA were studied following exposure of intact Chinese hamster ovary cells to chromate. Rigorous extraction with EDTA, acid, or base was required to release the amino acids cross-linked to the DNA isolated from control or chromate-treated cells by standard procedures (i.e., proteinase K, phenol, etc.). Amino acids resisting extraction from DNA were not studied since analysis was limited to those that could be released by these procedures. There was a chromate dose-dependent increase in amino acids complexed with the DNA that could be released by EDTA, acid, and base, and these amino acids were separated by HPLC and identified. Substantial increases in cysteine, glutamine, glutamic acid, histidine, threonine, and tyrosine were found as a function of increasing concentrations of chromate. There was also a time-dependent increase in complexing of these amino acids to the DNA by chromate. The amino acids found complexed to DNA in intact cells by chromate were thought to originate from reactions of free amino acids or small peptides with the DNA rather than being proteolytic products derived from larger proteins that were cross-linked to the DNA. This was supported by a number of experiments: a) free amino acids or bovine serum albumin (BSA) were cross-linked by chromium to DNA in vitro and the DNA was isolated by standard procedures.(ABSTRACT TRUNCATED AT 250 WORDS)
Stat Bite U.S. Trends in Melanoma Incidence and Mortality
Authors: C. Frey, A. Hartman
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Stat Bite U.S. Trends in Melanoma Incidence and Mortality Get access Carolin Frey, Ph.D., Carolin Frey, Ph.D. Search for other works by this author on: Oxford Academic PubMed Google Scholar Anne Hartman Anne Hartman Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 23, 4 December 1991, Page 1705, https://doi.org/10.1093/jnci/83.23.1705 Published: 04 December 1991
Toxic Effects of Levamisole in a Cocaine User
Authors: Trevor T Muirhead, Melody J Eide
Journal: New England Journal of Medicine (2011)

A 54-year-old woman presented with a 2-day history of a painful, enlarging rash over her face (Panel A), ears (Panel B), breasts, and extremities. Laboratory studies revealed neutropenia (neutrophil count, 1070 per cubic millimeter) and lymphopenia (lymphocyte count, 680 per cubic millimeter); the detection of antineutrophil cytoplasmic antibodies (ANCA) by immunofluorescence testing showed the perinuclear pattern (p-ANCA) and the cytoplasmic pattern (c-ANCA), and an enzyme-linked immunosorbent assay revealed a proteinase-3 antibody titer of 1:320. Toxicologic screening of the urine was positive for cocaine and opiates. The urine levamisole level 2 days after admission was positive at 920 ng per milliliter. . . .
OP03 * BORDER TRANSITION ACROSS THE INVASIVE MARGIN OF GLIOBLASTOMAS DO NOT PROVIDE MEASURES OF TUMOUR INVASION: A DIFFUSION TENSOR STUDY
Authors: C. Zhang, A. Frary, N. R. Bonzaier, T. Larkin, S. J. Price
Journal: Neuro-Oncology (2014)

INTRODUCTION: Invasion is a cardinal feature of glioblastomas - diffusely invasive tumours have worse prognosis than less invasive gliomas. Diffusion tensor imaging (DTI) provides a non-invasive method of studying the invasive margin. Studies measuring diffusion changes across the tumour margin, a measure of changes of cellularity, suggest it may be a marker of invasiveness. In this study we have assessed isotropic diffusion changes across the DTI defined tumour margin. METHOD: 47 patients with glioblastomas were studied before 5-ALA guided resection of these tumours before starting chemoradiotherapy. Imaging included anatomical imaging and DTI - which was processed into isotropic (p) and anisotropic (q) components. The area with the largest separation of the p and q was selected as the most invasive region and a line drawn across the border of p (the margin between invasive tumour and normal brain). The transition was quantified by the border transition gradient measured from the slope of point either side of the margin as well as whether the p values were more than12% above normal brain at the margin. These values were compared with time to progression (TTP). RESULTS: There was no correlation between the border transition gradient across the margin and TTP (r= 0.3, P = 0.85). There was an increased TTP where the p values were below threshold at the margin, but this was not significant (424 days vs. 326 days; P = 0.74). CONCLUSION: Transitional measurements across the DTI defined invasive margin do not provide information on the invasive nature of tumours and the time to progression.