tbuckley/cabot-search huggingface dataset:
In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
Authors: Mario Iurlaro, Gordon R. McInroy, Heather E. Burgess, Wendy Dean, Eun-Ang Raiber, Martin Bachman, Dario Beraldi, Shankar Balasubramanian, Wolf Reik
Journal: Genome biology (2016)

Genome-wide methylation of cytosine can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes. TET is able to oxidise 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TDG can excise the oxidative products 5fC and 5caC, initiating base excision repair. These modified bases are stable and detectable in the genome, suggesting that they could have epigenetic functions in their own right. However, functional investigation of the genome-wide distribution of 5fC has been restricted to cell culture-based systems, while its in vivo profile remains unknown. Here, we describe the first analysis of the in vivo genome-wide profile of 5fC across a range of tissues from both wild-type and Tdg-deficient E11.5 mouse embryos. Changes in the formylation profile of cytosine upon depletion of TDG suggest TET/TDG-mediated active demethylation occurs preferentially at intron-exon boundaries and reveals a major role for TDG in shaping 5fC distribution at CpG islands. Moreover, we find that active enhancer regions specifically exhibit high levels of 5fC, resulting in characteristic tissue-diagnostic patterns, which suggest a role in embryonic development. The tissue-specific distribution of 5fC can be regulated by the collective contribution of TET-mediated oxidation and excision by TDG. The in vivo profile of 5fC during embryonic development resembles that of embryonic stem cells, sharing key features including enrichment of 5fC in enhancer and intragenic regions. Additionally, by investigating mouse embryo 5fC profiles in a tissue-specific manner, we identify targeted enrichment at active enhancers involved in tissue development.
An Evaluation of the Antiproteolytic Reaction of Serum as a Test for Malignant Neoplasia&lt;xref ref-type="fn" rid="fn1"&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/xref&gt;&lt;xref ref-type="fn" rid="fn2"&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/xref&gt;
Authors: Eugene E. Cliffton, M. D.
Journal: JNCI Journal of the National Cancer Institute (1950)

An Evaluation of the Antiproteolytic Reaction of Serum as a Test for Malignant Neoplasia Get access Eugene E. Cliffton, M. D. Eugene E. Cliffton, M. D. Department of Surgery (Oncology), Yale University School of Medicine, New Haven, Conn. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 11, Issue 1, August 1950, Pages 33–50, https://doi.org/10.1093/jnci/11.1.33 Published: 01 August 1950 Article history Received: 22 March 1950 Published: 01 August 1950
Neprilysin Inhibitors: Emerging Therapy for Heart Failure
Authors: Anjali Tiku Owens, Susan Brozena, Mariell Jessup
Journal: Annual Review of Medicine (2016)

Biologically active natriuretic peptides (NPs) are an integral part of cardiac homeostasis as they help to maintain sodium and fluid balance. When homeostasis is perturbed by neurohormonal activation in heart failure, levels of NPs rise in response. Neprilysin (NEP) is a naturally occuring enzyme that breaks down NPs. Scientists have recently discovered a novel pharmacologic agent that combines a NEP inhibitor and an angiotensin receptor blocker. In a large clinical trial, this new drug was found to reduce hospitalization and mortality in systolic heart failure. The challenges of implementing this therapy include patient selection, cost, and risk of side effects including angioedema and Alzheimer's disease.
Desipramine and methylphenidate combination treatment for depression: case report
Authors: E J Drimmer, M J Gitlin, H E Gwirtsman
Journal: American Journal of Psychiatry (1983)

The authors successfully treated a chronically depressed man with a combination of desipramine and methylphenidate. Methylphenidate did not change his serum desipramine level, and the authors speculate that its ability to potentiate tricyclic responsiveness may be due to its dopaminergic activity.
Minimal Renal Toxicity after Rituximab DHAP with a Modified Cisplatin Application Scheme in Patients with Relapsed and Refractory Diffuse Large B-Cell Lymphoma
Authors: Katharina Lisenko, Fabienne McClanahan, Tilman Schöning, Mark-Alexander Schwarzbich, Martin Cremer, Tobias Dittrich, Anthony D. Ho, Mathias Witzens-Harig
Journal: Blood (2015)
Changes in Insurance Coverage Among Hospitalized Nonelderly Adults After Medicaid Expansion in Michigan
Authors: Matthew M. Davis, Achamyeleh Gebremariam, John Z. Ayanian
Journal: JAMA (2016)

Expanded insurance coverage through the Affordable Care Act (ACA) may reduce the burden of uncompensated care for hospitals.2][3][4] However, no peer-reviewed publications have assessed statewide trends in coverage with ACAsponsored expansion and also examined between-hospital differences in coverage trends.Methods | Michigan expanded Medicaid coverage in 2014 under the ACA. 5 We compared insurance coverage for hospitalized patients during initial implementation of the Healthy Michigan Plan in April-December 2014 with corresponding months in 2012 and 2013.We also examined patterns at the level of individual hospitals to ascertain whether the consequences of expanded coverage were uniform across institutions.The Michigan Inpatient Database is compiled by the Michigan Health and Hospitals Association from a complete census of discharge data reported by acute care hospitals in Michigan.In this study, the "uninsured" coverage category included discharges listing the primary payer as "self-pay" or "no charge."Analyses of payer categories (uninsured, Medicaid, Medicare, private, other) were performed for adults aged 18 through 64 years to correspond with coverage expansion provisions for nonelderly adults sponsored by the ACA.Discharges with missing payer status (<0.2% in all years) were excluded.The University of Michigan Medical School institutional review board declared this study of deidentified data as not regulated for human subjects review.Results | Among 130 hospitals in Michigan that provide acute care, 454 658 discharges occurred for nonelderly adults in April-December 2012, 443 861 in April-December 2013 (2-year mean, 449 260), and 445 161 in April-December 2014.In April-December, uninsured patients represented 5.8% in 2012 and 6.0% in 2013 of nonelderly adult discharges compared with 2.0% in 2014 (Table ).The proportion of discharges for nonelderly adults with Medicaid increased from 22.9% in 2012 and 23.8% in 2013 to 29.9% in 2014.The changes in proportions of discharges with private coverage and Medicare over the same period were smaller.Most of the changes in the proportions of uninsured and Medicaid discharges occurred in the first quarter of Medicaid expansion and remained stable for the rest of 2014 (quarters 1, 2, 3, 4: uninsured, 5.7%, 2.4%, 2.0%, 1.8%; Medicaid, 25.5%, 29.4%, 30.1%, 30.0%).
Sex differences and hormonal effects on gut microbiota composition in mice
Authors: Elin Org, Margarete Mehrabian, Brian W. Parks, Petia Shipkova, Xiaoqin Liu, Thomas A. Drake, Aldons J. Lusis
Journal: Gut Microbes (2016)

We previously reported quantitation of gut microbiota in a panel of 89 different inbred strains of mice, and we now examine the question of sex differences in microbiota composition. When the total population of 689 mice was examined together, several taxa exhibited significant differences in abundance between sexes but a larger number of differences were observed at the single strain level, suggesting that sex differences can be obscured by host genetics and environmental factors. We also examined a subset of mice on chow and high fat diets and observed sex-by-diet interactions. We further investigated the sex differences using gonadectomized and hormone treated mice from 3 different inbred strains. Principal coordinate analysis with unweighted UniFrac distances revealed very clear effects of gonadectomy and hormone replacement on microbiota composition in all 3 strains. Moreover, bile acid analyses showed gender-specific differences as well as effects of gonodectomy, providing one possible mechanism mediating sex differences in microbiota composition.
Glutathione and Glutathione Utilizing Enzymes Are Key Determinants in the Sensitivity of Myeloma Cells to Arsenic Trioxide as Well as Its Mechanism of Action.
Authors: Delia Gutman, Alejo Morales, Jennifer M. McCafferty, Emilio Volz, Tatiana Eguizabal, Kelvin P. Lee, Lawrence H. Boise
Journal: Blood (2005)
Androgen deprivation therapy (ADT) plus docetaxel (D) versus ADT alone for hormone-naïve metastatic prostate cancer (PCa): Long-term analysis of the GETUG-AFU 15 phase III trial.
Authors: Gwenaelle Gravis, Jean-Marie Boher, Florence Joly, Stephane Oudard, Laurence Albiges, Franck Priou, Igor Latorzeff, Remy Delva, Ivan Krakowski, Brigitte Laguerre, Frederic Rolland, Christine Theodore, Gael Deplanque, Jean-Marc Ferrero, Damien Pouessel, Loic Mourey, Philippe Beuzeboc, Muriel Habibian, Michel Soulie, Karim Fizazi
Journal: Journal of Clinical Oncology (2015)

140 Background: ADT is standard treatment for metastatic PCa. Recently, the E3805 trial reported a survival benefit for (ADT+D) in high volume disease (HVD) patients, whereas the GETUG-15 trial did not demonstrate a survival improvement among a less selected group of patients (pts) with hormone-naïve metastatic PCa. We report an updated analysis of overall survival (OS) of the GETUG 15 trial and aligned the definition of HVD and low volume disease (LVD) subgroups. Methods: Long-termOS was analyzed in the intention-to-treat population (n=385 pts). Additionally, we retrospectively assessed the tumor volume as defined per E3805criteria in all patients enrolled in GETUG 15. Results: See Table. With a median follow-up of 82.9 months (95%CI [80.5-84.3]) (vs 50 months (95%CI [80.5-84.3] in the original analysis), 212 patients (55%) have died. The median OS is 46.5 [39.1-60.6] and 60.9 months [46.1-71.4] in the ADT and in the ADT + D arms, respectively (HR: 0.9 [95%CI: 0.7-1.2]). In HVD patients (n=183, 47.5%), median OS rates were 35.1 months [29.9-44.2] in the ADT alone arm and 39 months [28-52.6] in the ADT+D arm (HR: 0.8 [0.6-1.2]). Conclusions: With longer follow-up, the addition of docetaxel to ADT did not significantly improve OS in patients with hormone-naïve metastatic prostate cancer. In the retrospective analysis using aligned definition of volume of metastasis as E3805, the HVD outcomes were similar to E3805 for ADT alone and there was a non-significant 4 months increase in OS with ADT+D, in this underpowered subset. Clinical trial information: 00104715. [Table: see text]
Outcome of Patients With Recurrent Osteosarcoma Enrolled in Seven Phase II Trials Through Children's Cancer Group, Pediatric Oncology Group, and Children's Oncology Group: Learning From the Past to Move Forward
Authors: Joanne P. Lagmay, Mark D. Krailo, Ha Dang, AeRang Kim, Douglas S. Hawkins, Orren Beaty, Brigitte C. Widemann, Theodore Zwerdling, Lisa Bomgaars, Anne-Marie Langevin, Holcombe E. Grier, Brenda Weigel, Susan M. Blaney, Richard Gorlick, Katherine A. Janeway
Journal: Journal of Clinical Oncology (2016)

The use of radiographic response as the primary end point in phase II osteosarcoma trials may limit optimal detection of treatment response because of the calcified tumor matrix. We performed this study to determine if time to progression could be used as an end point for subsequent studies.We performed a retrospective analysis of outcome for patients with recurrent/refractory osteosarcoma enrolled in one of seven phase II trials conducted by the Children's Oncology Group and predecessor groups from 1997 to 2007. All trials used RECIST or WHO radiographic response criteria and the primary end point of response rate. The following potential prognostic factors-age, trial, number of prior chemotherapy regimens, sex, and race/ethnicity-were evaluated for their impact on event-free survival (EFS). We used data from a phase II study (AOST0221) of patients with osteosarcoma who were given inhaled granulocyte-macrophage colony-stimulating factor with first pulmonary recurrence who had an EFS as well as biologic end point to determine the historical disease control rate for patients with fully resected disease.In each included trial, the drugs tested were determined to be inactive on the basis of radiographic response rates. The EFS for 96 patients with osteosarcoma and measurable disease was 12% at 4 months (95% CI, 6% to 19%). There was no significant difference in EFS across trials according to number of prior treatment regimens or patient age, sex, and ethnicity. The 12-month EFS for the 42 evaluable patients enrolled in AOST0221 was 20% (95% CI, 10% to 34%).The EFS was uniformly poor for children with recurrent/refractory osteosarcoma in these single-arm phase II trials. We have now constructed baseline EFS outcomes that can be used as a comparison for future phase II trials for recurrent osteosarcoma.
A Successful Model To Decrease Early and Preventable Deaths In Acute Promyelocytic Leukemia (APL) Through The Use Of a Simplified Algorithm and Expert Support In Experienced As Well As Smaller Leukemia Treatment Centers In The US
Authors: Anand P. Jillella, Ravindra B. Kolhe, Farrukh Awan, Kavita Natrajan, Vamsi Kota
Journal: Blood (2013)
Atopic dermatitis, atopic eczema, or eczema? A systematic review, meta‐analysis, and recommendation for uniform use of ‘atopic dermatitis’
Authors: R. Kantor, J. P. Thyssen, A. S. Paller, J. I. Silverberg
Journal: Allergy (2016)

Abstract Background The lack of standardized nomenclature for atopic dermatitis ( AD ) creates unnecessary confusion for patients, healthcare providers, and researchers. It also negatively impacts accurate communication of research in the scientific literature. We sought to determine the most commonly used terms for AD . Methods A systematic review of the MEDLINE , EMBASE , and LILACS (1945–2016) for the terms AD , atopic eczema ( AE ), and multiple other eczematous disorders. Results In MEDLINE , 33 060 were identified, of which 21 299 (64.4%) publications used the term ‘ AD ’, 15 510 (46.9%) ‘eczema’, and only 2471 (7.5%) AE . Most of these publications used the term AD (82.0%) or eczema (70.8%) without additional nomenclature; only 1.2% used AE alone. Few publications used the terminology ‘childhood eczema’, ‘flexural eczema’, ‘infantile eczema’, ‘atopic neurodermatitis’, or ‘Besnier's prurigo’. AD was rarely used until the late 1970s, after which it became the most commonly used of the three terms and continuously increased until 2015. Atopic eczema decreased between 2008 and 2015. Atopic dermatitis was the most commonly used term in studies across almost all publication types, languages, and journals. Conclusion Atopic dermatitis is the most commonly used term and appears to be increasing in popularity. Given that eczema is a nonspecific term that describes the morphological appearance of several forms of dermatitis, we strongly suggest the use of a more specific term, AD, in publications, healthcare clinician training, and patient education. Support from researchers, reviewers, and editors is key to success.
P-172 Initial experience of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for treatment of peritoneally disseminated gastric cancer
Authors: V. Khomyakov, A. Ryabov, L. Bolotina, A. Ivanov, V. Cheremisov, I. Kolobaev, A. Chayka, D. Sobolev, A. Utkina
Journal: Annals of Oncology (2016)
THE DIAGNOSTIC SIGNIFICANCE OF HEMOPTYSIS.
Authors: T LAES
Journal: JAMA (1897)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Comparison of Standard and Steerable Catheters for Bile Duct Cannulation in ERCP
Authors: H-U Laasch, A Tringali, L Wilbraham, A Marriott, R E England, M Mutignani, V Perri, G Costamagna, D F Martin
Journal: Endoscopy (2003)

Background and Study Aims: The aim of the study was to compare two steerable endoscopic retrograde cholangiopancreatography (ERCP) catheters with regard to speed and safety in cannulating the common bile duct. Patients and Methods: A standard cannula, a short-nosed sphincterotome, and a bendable catheter were used. At two tertiary centres, a total of 312 patients were randomly assigned to receive treatment with one of three catheters and either by a trainee or an expert endoscopist. When cannulation failed, a further attempt was made with a different catheter. If this failed, a change in operator or other manoeuvres followed. The following were assessed: time to cholangiography and deep cannulation, number of attempts and success rates of cannulation, number of pancreatic duct injections, success of catheter cross-over, and complication rates. Results: Both steerable catheters were significantly better for the initial cholangiogram than the standard catheter (standard catheter 75 %, bendable catheter 84 %, sphincterotome 88 %; P = 0.038), with no significant differences between the bendable catheter and the sphincterotome. Both were also better for deep cannulation of the bile duct (standard cannula 66 %, bendable catheter 69 %, sphincterotome 78 %; P = 0.15). When the standard catheter failed, a steerable catheter succeeded in 26 % of cases. Trainees experienced greater benefit from using steerable catheters. For experts, the bendable catheter was the quickest to achieve cholangiography and deep cannulation. Further manoeuvres had an 85-90 % success rate in allowing biliary access. Twenty of 23 needle-knife papillotomies (87 %) were successful when other methods had failed. The overall ERCP success rate was 97 %. Pancreatitis occurred in 5.3 % of cases. Conclusions: Steerable catheters allow faster access and can succeed when a standard catheter fails. If cannulation is difficult, changing the catheter should be considered at an early stage. Needle-knife papillotomy is a successful technique in expert hands.
ANGINA PECTORIS, CARDIAC ARRHYTHMIAS, AND ADRENERGIC BLOCKING DRUGS
Authors: O E AUFRANC, W N JONES, W H HARRIS
Journal: JAMA (1964)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
New techniques of on-line biological sample processing and their application in the field of biopharmaceutical analysis
Authors: Jie Peng, Fang Tang, Rui Zhou, Xiang Xie, Sanwang Li, Feifan Xie, Peng Yu, Lingli Mu
Journal: Acta Pharmaceutica Sinica B (2016)

Biological sample pretreatment is an important step in biological sample analysis. Due to the diversity of biological matrices, the analysis of target substances in these samples presents significant challenges to sample processing. To meet these emerging demands on biopharmaceutical analysis, this paper summarizes several new techniques of on-line biological sample processing: solid phase extraction, solid phase micro-extraction, column switching, limited intake filler, molecularly imprinted solid phase extraction, tubular column, and micro-dialysis. We describe new developments, principles, and characteristics of these techniques, and the application of liquid chromatography–mass spectrometry (LC–MS) in biopharmaceutical analysis with these new techniques in on-line biological sample processing.
The Mir-17~92 Cluster Enhances Cell Growth and Resistance to Chemotherapy in Mantle Cell Lymphoma by Down-Regulating PTEN, PHLPP2 and BIM
Authors: Enyu Rao, Timothy McKeithan, Chunsun Jiang, Ming Ji, Javeed Iqbal, George Wright, Louis M. Staudt, Yong Zhao, Wing C. Chan, Kai Fu
Journal: Blood (2008)
Time to Eliminate the Step 2 Clinical Skills Examination for US Medical Graduates
Authors: Lydia A. Flier, Christopher R. Henderson, Carolyn L. Treasure
Journal: JAMA Internal Medicine (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal