tbuckley/cabot-search huggingface dataset:
Failure to find evidence for linkage or association between the dopamine D3 receptor gene and schizophrenia
Authors: O Sabaté, D Campion, T d'Amato, M P Martres, P Sokoloff, B Giros, M Leboyer, M Jay, F Guedj, F Thibaut
Journal: American Journal of Psychiatry (1994)

This study was performed to assess the possible involvement of the dopamine D3 receptor gene (DRD3) in the etiology of schizophrenia. The authors' approach included a population study and a family study using both parametric (lod score) and nonparametric (affected pedigree member) methods of linkage analysis.Two different DNA markers were studied at the DRD3 locus. The family study included 35 multiplex families of schizophrenic subjects for the linkage analyses. The population study involved 50 unrelated schizophrenic subjects and 50 normal comparison subjects from the same ethnic and geographic origin.Whichever clinical classification was used to define the pathological phenotype (schizophrenia or schizophrenia spectrum), the results of the lod score and affected pedigree member studies did not provide any evidence of linkage of the DRD3 gene to the illness. The negative results of the association study reinforce these results.The hypothesis that the DRD3 gene has a predisposing role in schizophrenia was not supported by these population and family studies. However, the possibility that this gene has a role in the etiology of the disease cannot be definitely excluded because of the intrinsic limitations of the methods of analysis and the number of subjects studied.
Gastrin
Authors: John H. Walsh, Morton I. Grossman
Journal: New England Journal of Medicine (1975)

Gastrin in Human DiseaseHypergastrinemia without Gastric HypersecretionPernicious anemia; atrophic gastritis. Serum gastrin concentrations are increased in patients with atrophic gastritis. The increase is especially marked in gastritis that spares the antrum and is associated with circulating parietal-cell antibodies. In some patients with this type of gastritis pernicious anemia develops as a result of loss of intrinsic-factor secretion.126 Approximately three fourths of the patients with pernicious anemia were found to have increased fasting serum gastrin concentrations, and about one third were in the hypergastrinemic range characteristic of Zollinger-Ellison syndrome.127 Chronic hypochlorhydria apparently leads to . . .
Syphilis
Authors: Carolyn J. Hildreth
Journal: JAMA (2009)

Syphilis Syphilis, a disease caused by the Treponema pallidum bacterium continues to be an important public health problem.Syphilis is a sexually transmitted infection (STI) and can be transmitted by all types of intimate contact including genital, oral, and anal sex.Use of a condom during all sexual activity can reduce the risk of infection.Individuals who are infected with the human immunodeficiency virus (HIV) are particularly susceptible to contracting and spreading syphilis and are often unaware of either diagnosis.Treatment at any stage is important because untreated syphilis can result in life-threatening illness.The February 18, 2009, issue of JAMA includes an article about treatment of syphilis.
Psychotherapy and pharmacotherapy: conceptual lenses
Authors: J P Docherty, S R Marder, D P Van Kammen, S G Siris
Journal: American Journal of Psychiatry (1977)

Of the many difficulties in maintaining an integration of psychotherapeutic and pharmacotherapeutic treatment, one of the most important is "the problem of bimodal relatedness", that is, the distinction between relating to the patient as a diseased organ or object of study and as a disturbed person. The authors identify the forces that act to inappropriately emphasize one mode or the other and discuss major difficulties that arise because of failure to maintain a bimodal relatedness. In a setting of combined therapy, maintaining and safeguarding the optimal relationship of collaborative subject-subject relatedness can prevent the emergence of problem destructive to effective psychiatric treatment and research.
Alternating combination of alkylating agents and vincristine, doxorubicin, and dexamethasone in multiple myeloma.
Authors: C Lejeune, J J Sotto, J G Fuzibet, J F Rossi, G Lepeu, R Bataille
Journal: Journal of Clinical Oncology (1991)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1991.9.6.1090 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2033423 Alternating combination of alkylating agents and vincristine, doxorubicin, and dexamethasone in multiple myeloma. C LejeunexC LejeuneSearch for articles by this author , J J SottoxJ J SottoSearch for articles by this author , J G FuzibetxJ G FuzibetSearch for articles by this author , J F RossixJ F RossiSearch for articles by this author , G LepeuxG LepeuSearch for articles by this author , R BataillexR BatailleSearch for articles by this author https://doi.org/10.1200/JCO.1991.9.6.1090 PDF "Alternating combination of alkylating agents and vincristine, doxorubicin, and dexamethasone in multiple myeloma.." Journal of Clinical Oncology, 9(6), pp. 1090–1091© 1991 by American Society of Clinical Oncology
Metabolism of Serum Triglycerides and Free Fatty Acids by Myocardium
Authors: A GOUSIOS, J M FELTS, R J HAVEL
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Use of magnetic resonance imaging in psychiatry [published erratum appears in Am J Psychiatry 1988 Apr;145(4):540]
Authors: H J Garber, J B Weilburg, F S Buonanno, T C Manschreck, P F New
Journal: American Journal of Psychiatry (1988)

The authors report four cases in which magnetic resonance imaging (MRI) provided diagnostic information not apparent by X-ray CAT in clinical investigations of patients with neuropsychiatric disorders. The relative capabilities and contraindications for MRI and CAT are reviewed. The authors suggest that MRI is indicated 1) instead of CAT when there is suspicion of neuropathology that is better visualized by MRI because of its type or location and 2) after CAT when an atypical psychiatric symptom or presentation has not been definitively evaluated by means of CAT.
FRI0547 Comparison Between Shoulder Injections and Parenteral Administration of Corticoids in Superespinatus Tendinitis
Authors: C.A. Guillen Astete, J. Bachiller Corral, A.L. Boteanu
Journal: Annals of the Rheumatic Diseases (2015)

<h3>Background</h3> Meta-analyses on management of shoulder pain suggest that corticoids perijoint injection or its intramuscular administration has equivalent results in terms of relieve of symptoms. However, most of those meta-analyses include studies which do not distinguish among the different kinds of tendonitis, presence or absence of calcifications and if the puncture was or was not guided by ultrasonography. <h3>Objectives</h3> The aim of this study is to compare the effect of intramuscular corticoids administrations and perijoint injection in patients diagnosed by superspinatus tendinosis. <h3>Methods</h3> Observational study based on common clinical practice (protocols of shoulder pain follow-up of the Unit of rheumatologic and musculoskeletal urgencies). We included patients who were assessed due to shoulder pain in our A&amp;E department with diagnosis of superspinatus tendinosis with or without calcifications. All patients fulfilled a follow-up card with data related to their pain level (Visual analogic scale from 0 to 10) and were assessed again three weeks after. In this second visit data were collected. Main variable was the pain level at 7th and 21st days. Corticoid used was triamcinolone (40mg). Shoulder injections included also 2ml of 2% Mepivacaine. <h3>Results</h3> 35 patients with calcifications and 54 patients without calcifications were included. 31/54 Patients without calcifications underwent a conventional shoulder injection by posterior access, rest of them received an intramuscular dose. In patients with calcifications, 15/35 underwent a conventional shoulder injection by posterior access, 11/35 by lateral access guided by ultrasonography and 9/35 received intramuscular treatment. Pain level change did not show statistical differences in patients with calcifications regardless the way of corticoids administration. In patients with calcifications the change in pain level was significant higher in patients who underwent a guided shoulder injection than the conventional puncture and the intramuscular administration at the first week (3.1, 5.3 and 5.4 respectively; <i>P</i>&lt;0.0001) and 21st day (2.2, 5.8 and 6.0 respectively; <i>P</i>&lt;0.0001). Figure 1 details our findings. <h3>Conclusions</h3> Our results are aligned with previous studies demonstrating that intramuscular or perijoint injection of corticoids are equally efficient in pain control, however, benefit of ultrasonographic guidance in patients with a superspinatus calcification is clinically relevant and measurable since the first week. We recommend performing ultrasonographic-guided corticoids injections in patients with superespinatus calcifications. <h3>Disclosure of Interest</h3> None declared
Anterior Uveitis in Children
Authors: R Witmer
Journal: JAMA (1963)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Staphylococci in a Community Hospital
Authors: Wei-Ping Loh, Russell B. Street
Journal: New England Journal of Medicine (1957)

THE frequent occurrence of antibiotic-resistant staphylococci from hospitalized patients has been repeatedly reported in the recent literature.1 2 3 4 5 It is thought that this phenomenon is related to the high carrier rate of hospital personnel. This view has been supported by the studies of Gould and Allen,6 who, by carrying out antibiotic-sensitivity testing and bacteriophage typing, established the fact that staphylococcal infections in hospitalized patients were derived from hospital nasal carriers. It has been further supported by the recent work of Brodie et al.,7 who reported that residence in the hospital for a week resulted in an increase in the nasal-carrier rate . . .
The European Community Strategy Against Antimicrobial Resistance
Authors: S Bronzwaer, A Lönnroth, R Haigh
Journal: Eurosurveillance (2004)

In 2001 the European Commission presented a 'Community strategy against Antimicrobial Resistance'. In previous years, the problem was addressed through an increasing number of isolated measures, but in this strategy the Commission outlined a comprehensive European Community approach across all sectors. The strategy consists of fifteen actions in four key areas: surveillance, prevention, research and product development, and international cooperation. An important part of this strategy is the 'Council Recommendation on the prudent use of antimicrobial agents in human medicine'. The Recommendation provides a detailed set of public health actions to contain antimicrobial resistance. This paper presents the eleven points of action of the strategy that are directly related to human medicine, and discusses related European Community activities. Under the new public health programme as well as under the research programme of the European Union, antimicrobial resistance is a key priority.
Prolonged psychosis attributed to phencyclidine: report of three cases
Authors: J M Rainey, M K Crowder
Journal: American Journal of Psychiatry (1975)

After ingesting street drugs sold as "PCP," "THC," and "methadone," three young men developed schizophreniform psychoses, analgesia, anesthesia, and amnesia for the psychotic state. Except for their unusually long duration of 2 to 4 weeks, these reactions resembled phencyclidine psychoses. The authors are aware of other phencyclidine-related hospital admissions but could find no information on phencyclidine in recently published handbooks on drug abuse.
Chronic Lymphocytic Leukemia Cells: Rosette Formation and Adherence to Nylon Fiber Columns2
Authors: Alan C. Aisenberg, John C. Long, Barbara Wilkes
Journal: JNCI Journal of the National Cancer Institute (1974)

Journal Article Chronic Lymphocytic Leukemia Cells: Rosette Formation and Adherence to Nylon Fiber Columns Get access Alan C. Aisenberg, Alan C. Aisenberg Search for other works by this author on: Oxford Academic PubMed Google Scholar John C. Long, John C. Long Search for other works by this author on: Oxford Academic PubMed Google Scholar Barbara Wilkes Barbara Wilkes Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 52, Issue 1, January 1974, Pages 13–17, https://doi.org/10.1093/jnci/52.1.13 Published: 01 January 1974 Article history Received: 06 July 1973 Accepted: 26 September 1973 Published: 01 January 1974
Development of an online database for diphtheria molecular epidemiology under the remit of the DIPNET project
Authors: T Dallman, S Neal, J Green, A Efstratiou
Journal: Eurosurveillance (2008)

The Diphtheria Surveillance Network (DIPNET), launched on 1 November 2006, is a 38-month programme bringing together 25 European Union partner countries (24 Member States and Turkey) and collaborating countries beyond Europe in a global dedicated surveillance network for diphtheria and related infections caused by Corynebacterium diphtheriae and C. ulcerans [1].
Abstract 640: Probing the tumorigenic properties of two pore potassium channels using inhibitory anti-KCNK9 mAbs
Authors: Han Sun, Liqun Luo, Bachchu Lal, John Laterra, Min Li
Journal: Cancer Research (2015)

Abstract Ion channels are important portals that facilitate ionic passage across membranes in all organisms. KCNK9, a member of the family of two-pore domain potassium K+ channels, mediates “leak” currents critical to maintaining cell resting membrane potentials. Since its identification, KCNK9 has been implicated in various human disorders including cancer. KCNK9 overexpression has been observed in melanoma, colorectal, breast and lung tumors and KCNK9 has been found to promote tumor survival and growth, by increasing resistance to hypoxia and apoptosis. However, KCNK9's underlying pathophysiologic mechanisms have been elusive due to the absence of specific inhibitors. Here, we describe the development of novel monoclonal antibodies directed against the KCNK9 extracellular domain and their molecular/cellular effects on KCNK9-expressing cells. Murine monoclonal IgG1 antibodies were raised against recombinant KCNK9 extracellular domains expressed in a mammalian system. 40 monoclonal antibodies were generated and demonstrated channel subtype-specific recognition of human KCNK9. Among them, 1 antibody designated Y4-mAb displayed sub-nanomolar binding affinity and inhibited KCNK9 channel conductance by up to 30% when tested in a fluorescent ion-influx assay. Through confocal microscopic analysis, channel inhibition was found to result from antibody-induced internalization and endocytosis of cell-surface channels. Y4-mAb induced up to 30∼40% reduction in cell viability and increased cell death in BEN non-small cell lung carcinoma cells and BT-549 and 410.4 breast cancer cells. In addition to “direct cell killing”, this antibody activated complement, resulting in complement-dependent cancer cell cytotoxicity in vitro. Initial experiments in vivo showed that systemic Y4-mAb inhibited the capacity of BEN non-small cell lung carcinoma cells to propagate subcutaneous tumor xenografts in nude mice (p&amp;lt;0.05). In conclusion, we have generated a high affinity KCNK9-specific monoclonal antibody that perturbs KCNK9 function and inhibits tumor cell survival and xenograft formation. Anti-KCNK9 antibodies have the potential to be valuable research tools and may lead to novel therapeutics. Moreover, our strategies should be generally applicable to studying the functions of other ion channels in cancer. Citation Format: Han Sun, Liqun Luo, Bachchu Lal, John Laterra, Min Li. Probing the tumorigenic properties of two pore potassium channels using inhibitory anti-KCNK9 mAbs. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 640. doi:10.1158/1538-7445.AM2015-640
IFNγ regulates Δ4BAFF alternative splicing
Authors: Gabriel J Tobón, Laurent Corcos, Pierre Youinou, Jacques-Olivier Pers
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> The B cell activating factor (BAFF) is a potent survival factor involved in the pathogenesis of autoimmune diseases. Recently, the authors reported the discovery of a new transcript for BAFF, Δ4BAFF - lacking exon 4 - mainly detected in autoimmune diseases. Δ4BAFF acts as a transcription factor of its own gene. However, the mechanisms implicated in Δ4BAFF induction and up-regulation remain unknown. the analysed the mechanisms of induction and regulation of Δ4BAFF. <h3>Materials and methods</h3> First, the authors tested if Δ4BAFF could be regulated by non-sense mediated decay (NMD) mechanisms, by blocking de novo protein synthesis. Secondly, the authors examined the effects of IFNγ on Δ4BAFF expression in different cell lines. Finally, to study the mechanisms implicated in the alternative splicing of exon 4, the authors transfected a minigene construct, centered on exon 4, into RAMOS cells. <h3>Results</h3> Δ4BAFF is not subjected to NMD-dependent degradation, despite the theoretical prediction, indicating that the transcript is stable. Incubation of cell lines with IFNγ showed induction of Δ4BAFF transcript. The induction of Δ4BAFF increased the expression of membrane-bound and soluble forms of BAFF. The effects of IFNγ on Δ4BAFF induction were confirmed using a minigene functional analysis of splicing. <h3>Conclusion</h3> Collectively, these results demonstrated that IFNγ induces Δ4BAFF, leading to an increase of BAFF. Our study provides an expanded conceptual view of BAFF gene regulation, and contributes to a better understanding of the mechanisms involved in BAFF up-regulation in autoimmunity. The authors expect to identify the proteins implicated in the control of <i>BAFF</i> exon 4 alternative mRNA splicing in these diseases.
Essential Tremor
Authors: Elan D. Louis
Journal: New England Journal of Medicine (2001)

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.A 66-year-old woman presents with tremor of the hands. She first noticed a mild tremor six years earlier, but the tremor has been worsening for the past two years. It occurs when she is using her hands, interfering with some activities of daily living. For example, she can no longer eat soup without spilling, put in her contact lenses, or apply lipstick. A writer, she is no longer able to write in longhand or type her manuscripts and must dictate them. The tremor causes a great deal of embarrassment in social situations. How should this patient be evaluated and . . .
The management of abdominal aortic aneurysms
Authors: Sachin Sule, Wilbert S Aronow
Journal: BMJ (2011)

Patients with symptomatic abdominal aortic aneurysms (AAAs) should undergo repair, regardless of AAA diameter, whereas guidelines for asymptomatic patients suggest repair for AAAs > or = 5.5 cm in diameter. For most patients with medium-sized AAAs, regular surveillance and intensive medical therapy are appropriate. Patients with an AAA should undergo intensive risk factor modification including cessation of smoking, treatment of hypertension, statins, beta-adrenergic blocking drugs, and angiotensin-converting enzyme inhibitors.
Course of premenstrual syndrome symptom severity after treatment
Authors: E W Freeman, K Rickels, S J Sondheimer
Journal: American Journal of Psychiatry (1992)

Patients from a randomized, double-blind, placebo-controlled study of progesterone suppository treatment for premenstrual syndrome (PMS) were followed up to determine poststudy PMS symptom levels and medication use.An average of 1 year after the end of the treatment study, 129 subjects were contacted for telephone interviews. All subjects met criteria for PMS before the progesterone suppository treatment, and their symptoms were confirmed by daily symptom reports throughout the study. The outcome measure at follow-up was the patient's global assessment of symptom severity, which was also rated by the subjects during the treatment study. The ratings at enrollment, end of study, and follow-up were compared.Only 27% of the subjects (N = 35) were taking medications for PMS at follow-up. Symptom severity at follow-up was less than at enrollment but greater than at the end of the study.Some of the improvement gained during treatment was maintained, but overall the subjects remained moderately symptomatic. Validation of the PMS condition, education, and support and caring may account for the symptom decreases during treatment, and the end of treatment and withdrawal of these conditions may account for the moderate return of symptoms.
Is more better?
Authors: W M Hryniuk
Journal: Journal of Clinical Oncology (1986)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1986.4.5.621 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3517239 Is more better? W M HryniukxW M HryniukSearch for articles by this author https://doi.org/10.1200/JCO.1986.4.5.621 PDF "Is more better?." Journal of Clinical Oncology, 4(5), pp. 621–622© 1986 by American Society of Clinical Oncology