tbuckley/cabot-search huggingface dataset:
Serologic Evidence of Occupational Psittacosis in Poultry-Plant Workers
Authors: Mila E. Rindge, Erwin L. Jungherr, John H. Scruggs
Journal: New England Journal of Medicine (1959)

PSITTACOSIS has been recognized for a number of years as an occupational hazard in some poultry-processing establishments. The outbreak in Faroe Islanders due to the processing of young fulmar petrels for food, reported by Rasmussen in 1939, is the first recorded example of psittacosis as an occupational disease.1 Outbreaks of psittacosis in turkey-processing plants in Texas,2 New Jersey,3 Iowa3 and Oregon4 have since been described.Although many millions of chickens are raised and processed annually in the United States, no outbreaks of psittacosis in chicken-processing plants have been described. However, sporadic cases due to contact with chickens have occurred. Meyer, . . .
1195 TEMPORAL DYNAMIC OF MUTATIONS ASSOCIATED WITH HCV PROTEASE INHIBITORS RESISTANCE IN NATURAL STRAINS OF HIV/HCV COINFECTED INDIVIDUALS
Authors: E. Messina, S. Bagaglio, M. Merli, L. Porrino, A.R. Pignataro, E. Boeri, H. Hasson, A. Lazzarin, A. Carbone, G. Morsica, C. Uberti-Foppa
Journal: Journal of Hepatology (2012)
SAT0070 Towards Adipokine Inhibition in Rheumatoid Arthritis: Is Adiponectin Inhibition Expected to Enhance Cardiovascular Metabolic Risk and Atherosclerosis?
Authors: P. H. Dessein, G. Norton, A. Woodiwiss, A. Solomon
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Leptin and particularly adiponectin are likely involved in the pathophysiology of rheumatoid arthritis (RA) and therefore potential new therapeutic targets. In the general population, leptin enhances and adiponectin reduces cardiovascular metabolic risk. Hence, adiponectin inhibition would be expected to result in increased cardiovascular disease risk<sup>1</sup>. However, whereas the presence of autoimmunity can impact on adipokine-cardiovascular risk relationships, it is unknown whether RA changes the influence of adipokines on cardiovascular metabolic risk. <h3>Objectives</h3> We determined whether RA impacts on the relationships of circulating leptin and adiponectin concentrations with cardiovascular risk factors and atherosclerosis. <h3>Methods</h3> We evaluated circulating adipokine concentrations by solid-phase sandwich enzyme-linked immunosorbant assays, metabolic risk factors and ultrasound determined carotid intima-media (cIMT) in 277 black Africans from a developing population; 119 had RA. Associations will determined in comprehensively adjusted mixed regression models. <h3>Results</h3> RA impacted on the relationships of adiponectin concentrations with lipid concentrations and blood pressure, independent of confounders including adiposity (interaction <i>P</i> &lt;0.05). This translated into an association of adiponectin concentrations with more favorable lipid variables including HDL cholesterol (partial R=0.335, <i>P</i>=0.0005), non-HDL cholesterol (partial R=-0.263, <i>P</i>=0.007) and triglyceride (partial R=-0.271, <i>P</i>=0.005) concentrations and total cholesterol-HDL cholesterol (partial R=-0.363, <i>P</i>=0.0002) and triglycerides-HDL cholesterol (partial R=-0.347, <i>P</i>=0.0003) ratios and, higher systolic (partial R=0.331, <i>P</i>=0.0006), diastolic (partial R=0.280, <i>P</i>=0.0004) and mean blood pressure (partial R=0.329, <i>P</i>=0.0007) in patients with RA. No independent associations between adiponectin concentrations and cardiovascular metabolic risk factors were observed in non-RA subjects. Leptin concentrations were not associated with metabolic risk after adjustment for adiposity in either RA or non-RA subjects. The cIMT did not differ by RA status and adipokine concentrations were unrelated to atherosclerosis. <h3>Conclusions</h3> This study suggests that upon adiponectin inhibition, cardiovascular risk factors and especially lipid profiles would require close monitoring. Nevertheless, neither adiponectin nor leptin inhibition are expected to alter overall cardiovascular risk and disease and should therefore be safe in RA. <h3>References</h3> Frommer KW et al. Ann Rheum Dis 2012; 71: 1724-32. <h3>Acknowledgements</h3> This study was supported by a South African Medical Research Council grant and the National Research Foundation. <h3>Disclosure of Interest</h3> None Declared
ACUTE KIDNEY INJURY FOLLOWING PRIMARY PERCUTANEOUS CORONARY INTERVENTIONS FOR ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION: TRENDS IN THE PAST FIFTEEN YEARS
Authors: Arie Steinvil, Hector Garcia Garcia, Toby Rogers, Sarkis Kiramijyan, Edward Koifman, Smita Negi, Sang Yeub Lee, Rebecca Torguson, Augusto Pichard, Lowell Satler, Itsik Ben-Dor, Ron Waksman
Journal: Journal of the American College of Cardiology (2016)
Medical Knowledge and Theatrical Interpretation
Authors: K. Wildenthal
Journal: JAMA (1967)

<h3>To the Editor:—</h3> The theater benefits when actors bring to the stage principles of modern medicine and psychiatry, as illustrated in Leon J. Saul's interesting paper (Othello: Projection in Art,<i>JAMA</i><b>200</b>:39-40, 1967). Lawrence Olivier's presentation of an Oedipal Hamlet, reflecting the Ernest Jones analysis of the play, is an example of new insight into characterization being stimulated by 20th-century psychiatry. Olivier has also provided a legitimate medical etiology for the otherwise arbitrary fourth-act swoon of Othello by giving him a dramatically effective hyperventilation syndrome. The Shakespeare character most in need of fresh appraisal has been King Lear. His words in the storm scenes are those of a senile, paranoid, and depressed old man without delusions of grandeur ( eg, "Here I stand your slave, a poor, infirm, weak and despised old man." "The little dogs and all... see, they bark at me.") Yet he is commonly
Abstract 1575: Zebrafish embryos as a model for studying the role of estrogen receptor β in cancer metastasis.
Authors: Ruixin Hao, Christoforos Thomas, Prasenjit Dey, Anders Ström, Catherine W. McCollum, Fotis Nikolos, Maria Bondesson, Jan-Ake Gustafsson
Journal: Cancer Research (2013)

Abstract Estrogen receptor β (ERβ) has been reported to impede cancer metastasis while estrogen receptor α (ERα) can promote cancer metastasis. Several splice variants of ERβ exist in humans and they may have different functions in different tissues, but the role of these differently spliced isoforms in cancer metastasis has not been well studied. Various model systems such as xenografting of cancer cells in mice and dogs have been used to study cancer metastasis. However, difficulties in monitoring living cancer cell metastasis in large non-transparent animals have been a limitation in these studies. Zebrafish embryos are transparent and their immune system is not fully developed until several days after post fertilization. These features make zebrafish a useful model for xenografting cancer cells and monitoring their migration. In addition, the large number of offspring and small size of the embryos make the zebrafish model amendable for high throughput screening and anti-metastasis drug discovery. In our studies, we co-microinjected breast cancer cell lines bearing ERβ constructs or control constructs, expressing fluorescent proteins of different colors, into zebrafish embryos at 48 hours post fertilization (hpf). After 2 hours recovery, fish embryos with cells circulating in the blood system were removed. Embryos that contained cells only in the original injection sites were incubated at 32°C to monitor the cancer cell migration daily using a fluorescence microscope. We found that ERβ expressing breast cancer cells were less migratory than the control cells and they remained at the original injection site to a large extent. We also examined the metastasis of prostate cancer cell lines expressing ERβ splice variants in our zebrafish xenograft model and found that cells with different ERβ splice variants exhibited different migration patterns. In conclusion, zebrafish embryos work as an effective model for studying the role of ERβ and its splice variants for cancer metastasis of diverse cancer cell lines. Citation Format: Ruixin Hao, Christoforos Thomas, Prasenjit Dey, Anders Ström, Catherine W. McCollum, Fotis Nikolos, Maria Bondesson, Jan-Ake Gustafsson. Zebrafish embryos as a model for studying the role of estrogen receptor β in cancer metastasis. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1575. doi:10.1158/1538-7445.AM2013-1575
Primary malignant melanoma involving the whole esophagus: a rare case with rarer presentation
Authors: Narendra Choudhary, Rajesh Puri, Ruchika Goel, Randhir Sud
Journal: Endoscopy (2014)

A 50-year-old man presented with a 2-month history of dysphagia and weight loss. A gastroscopy was done and showed an irregular submucosal bulge with a blue-black hue along the whole length of the esophagus ([Fig. 1] and [Fig. 2]). An endoscopic ultrasound was performed to look for vascularity, and showed a solid lesion with intraluminal and extraluminal growth limited to the serosa ([Fig. 3]). A computed tomography (CT) chest scan was done and this showed a solid lesion involving the whole length of the esophagus, loss of planes to the posterior trachea and aorta, and multiple bony lesions ([Fig. 4]). Endoscopic biopsies showed malignant cells arranged in sheets with moderate cytoplasm and moderately pleomorphic nuclei ([Fig. 5]), and a coarse brown granular pigment with Masson-Fontana stain. Immunohistochemistry results were as follows: CK negative, HMB-45, S-100, and Vimentin positive, suggestive of malignant melanoma. Primary malignant melanoma of the esophagus arises from melanin cells of the mucosal epithelial basal layer. It is a rare disease with extremely poor prognosis owing to its high metastatic potential. It represents 0.1 % to 0.2 % of all esophageal malignant tumors and generally presents with dysphagia (80 % cases), retrosternal or epigastric discomfort or pain [1] [2]. The lower third of the esophagus is the most common site followed by the middle and upper esophagus [1]. Our patient had involvement of the whole esophagus which makes it a rarer presentation. Diagnosis can be suspected during endoscopy if the mass has a black or dark brown pigment [2]. Positive immunohistochemistry for S-100, and HMB-45 helps in diagnosis [2]. Surgery is the mainstay of treatment when possible [1] [3].
NF-kB Complex Activation and Association of αB-Crystallin and Vimentin with Poor Prognosis in Primary Breast Cancer.
Authors: R. Sreseli, P. Quinlan, R. Quinlan, S. Bray, D. Kellok, L. Baker, L. Jordan, C. Purdie, A. Thompson
Journal: Cancer Research (2009)

Abstract Background: Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) is a protein complex found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, free radicals, cytokines et.c. NF-kB plays a key role in regulating the immune response and incorrect regulation of NF-kB has been linked to the development of cancer, several inflammatory and autoimmune diseases. The role of NF-kB, its subunits and pathways in breast cancer and in the surrounding stromal tissues remains uncertain. αB-crystallin is a heat shock protein, which function as stress-induced molecular chaperones to inhibit the aggregation of denatured proteins. Previous studies have identified αB-crystallin as a marker of poor prognosis for breast cancer and have suggested that it is an excellent marker for tumours of basal origin. The aim of this study is to examine, for the first time, NF-kB and αB-crystallin, vimentin and HSPs in the same set of breast cancers and stroma and relate this to clinical parameters including outcome.Methods: Tissue Micro Arrays of 0.6mm cores of 246 breast cancers were stained with antibodies to αB-crystallin, vimentin, HSP27 (antibody ERD5) and HSP27 82P and 12 subsequent antibodies for NF-kB (IKKa, Ser276, Ser32/36, 180/181, P52, 1kkygmma, P65, RELB, P100/P52, IkBa, cREL, and P50) and scored using the Quick Score Method.Results: Positive associations have been found between αB-crystallin and IKBA (P=0.001 Fishers exact test (FET)), RELB (P&amp;lt;0.001 (FET)) and SER32/36 (P=0.03 (FET)) whereas Vimentin was positively associated IKBA (P=0.003 (FET)), IKKA (P=0.001 (FET)), P50 (P=0.002 (FET)), RELB (P&amp;lt;0.001 (FET)) and SER32/36 (P=0.01 (FET)). Positive associations have also been found between HSP27 and P50 (P=0.002 (FET)), SER32/36 (P&amp;lt;0.001 (FET)). Antibodies such as 180/181 (P=0.04 Kaplan Meier Log Rank (KM), cREL (P=0.03 (KM)), IKBA (P=0.03 (KM)) and IKKA (P=0.01 (KM)) was associated with good survival and P50 (P=0.002 (KM)) and P65 (P=0.01 (KM)) to poor survival. Expression of αB-crystallin was associated with vimentin (P&amp;lt;0.001 (FET)). Its expression was linked to a low expression of the estrogen receptor. Vimentin expression was associated with estrogen receptor (ER) negative cancers and poor survival (P &amp;lt;0.001 (FET)), P=0.002 (KM Log Rank) respectively). In contrast to αB-crystallin, low expression of HSP27 was associated with low ER and progesterone receptor (PGR).Conclusions: Associations were found between various antibodies within the NF-kB pathway as well as the heat shock proteins αB-crystallin, vimentin and HSP27 with varying implications for overall survival. We aim to clarify the mechanisms to prevent the aggregation of stress-accumulated misfolded proteins and apoptosis resulting better survival. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 2143.
STATIN USE AND TITRATION PATTERNS IN THE FIRST YEAR FOLLOWING A CARDIOVASCULAR EVENT IN MEDICARE BENEFICIARIES
Authors: Katherine Mues, Yi Peng, Suying Li, Jill Hardin, Deborah Kim, Anne Beaubrun, Brian Bradbury, Keri Monda, Paul Muntner, Robert Rosenson, Charles Herzog
Journal: Journal of the American College of Cardiology (2016)
GW25-e4525 Upregulation of CXCR7 Expression Contributes to Increased Reendothelializaton Capacity of Early Endothelial Progenitor Cells from Patients with Essential Hypertension
Authors: Zhang Xiaoyu, Hui Zhi, Xin-Zhu Tong, Bin Zhang, Wen-Li Xie, Jun Tao
Journal: Journal of the American College of Cardiology (2014)
A Serologic Marker of Paraneoplastic Limbic and Brain-Stem Encephalitis in Patients with Testicular Cancer
Authors: Raymond Voltz, S. Humayun Gultekin, Myrna R. Rosenfeld, Elizabeth Gerstner, Joseph Eichen, Jerome B. Posner, Josep Dalmau
Journal: New England Journal of Medicine (1999)

In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a paraneoplastic disorder. Paraneoplastic limbic or brain-stem encephalitis occurs more frequently with testicular cancer than with most other cancers. We sought antineuronal antibodies that might be used in a diagnostic test for this syndrome.Immunohistochemical and immunoblotting techniques were used to detect serum and cerebrospinal fluid antibodies. Serologic screening of a complementary DNA library and Northern blotting were used to clone the target antigen and determine which tissues expressed it.Of 13 patients with testicular cancer and paraneoplastic limbic or brain-stem encephalitis (or both), 10 had antibodies in serum and cerebrospinal fluid against a 40-kd neuronal protein. These antibodies were used to clone a gene that we call Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a "brain-testis-cancer" gene related to other paraneoplastic syndromes and tumors.The serum of patients with subacute limbic and brain-stem dysfunction and testicular cancer contains antibodies against a protein found in normal brain and in testicular tumors. Detection of these antibodies supports the paraneoplastic origin of the neurologic disorder and could be of diagnostic importance.
Forced Vital Capacity in Idiopathic Pulmonary Fibrosis — FDA Review of Pirfenidone and Nintedanib
Authors: Banu A. Karimi-Shah, Badrul A. Chowdhury
Journal: New England Journal of Medicine (2015)

In 2014, the FDA approved two drugs for idiopathic pulmonary fibrosis that posed a regulatory challenge: the primary efficacy variable studied was the change in forced vital capacity, which hadn't been established as a surrogate for clinically meaningful benefit.
Telemedicine Creeping Into Use, Despite Obstacles
Authors: Kate Nagy
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Telemedicine Creeping Into Use, Despite Obstacles Get access Kate Nagy Kate Nagy Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 21, 2 November 1994, Pages 1576–1578, https://doi.org/10.1093/jnci/86.21.1576 Published: 02 November 1994
FRI0159 Progression of Early Axial Spondyloarthritis to Ankylosing Spondylitis after 6-Years Follow-Up
Authors: A. Bochkova, A. Levshakova, O. Rumyantseva, A. Smirnov, S. Erdes
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Early axial spondyloarthritis may resolve spontaneously, remain undifferentiated, or progress to ankylosing spondylitis or another spondyloarthritis. There are a need for improving the early diagnosis of ankylosing spondylitis (AS) and other spondyloarthritis (SpA). <h3>Objectives</h3> To assess the level of agreement between a SpA at baseline and 6 years later in cohort of patients with recent-onset axial spondyloarthritis. <h3>Methods</h3> Patients with duration of inflammatory back pain less than 2 years (between 2006 and 2008) were included. Patients followed-up in our department during about 6 years. And in patients who not followed-up in our department physician was contacted by phone to determine the final diagnosis. <h3>Results</h3> Diagnosis at baseline and 6 years later was known for 50 patients. At baseline all patients were diagnosed as axial SpA by ESSG, mean age 23.9 years, mean duration IBP 17 month, MRI sacroiliitis - 44% patients, HLA B27 positive were 96% patients, and peripheral arthritis/enthesitis have 28% patients. Mean follow-up was 5.9 years, and in the end of 2013 year 56% patients have AS; 20% patients have nr-axSpA (ASAS2009): 1 patient associated with psoriasis, 1 patients associated with IBD; 4% patients have peripheral SpA (ASAS 2012), 20% patients were healthy or have full remission. At baseline rise erythrocyte sedimentation rate (ESR) observed more frequently in patients with outcome to AS. Sacroiliitis is seen on MRI was a good predictor of future AS (likelihood ratio [LR] 3,0; specificity 67,6%) but not HLA–B27 positivity (LR 1,0; specificity 6,7%) <h3>Conclusions</h3> Only 56% nr-axSpA patients became AS after 6 years follow-up. MRI sacroiliitis and high erythrocyte sedimentation rate were predictors of future ankylosing spondylitis. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3324
P521 PROPOSAL FOR A NEW, STEPWISE ALGORITHM COMBINING LIVER AND SPLEEN STIFFNESS AND LOK SCORE FOR DIAGNOSIS OF LARGE ESOPHAGEAL VARICES IN PATIENTS WITH LIVER CIRRHOSIS
Authors: H. Stefanescu, B. Procopet, M. Platon Lupsor, A. Maniu, C. Radu
Journal: Journal of Hepatology (2014)
P03.07 * RESVERATROL ENHANCES RADIATION EFFECTS ON CLONOGENIC SURVIVAL IN HUMAN MEDULLOBLASTOMA CELL LINES
Authors: I. Patties, R. Kortmann, A. Glasow
Journal: Neuro-Oncology (2014)

BACKGROUND AND OBJECTIVE: In recent years, the natural plant polyphenol resveratrol (RV) attracted an increasing attention in tumor therapy. Currently, clinical trials for colon cancer and multiple myeloma have been completed. RV has to been shown to exhibit tumor preventive as well as anticancer effects. These are of particular interest for the therapy of pediatric medulloblastoma (MB), as low-risk MB patients (5-year survival up to 95 %) require a therapy focused on the reduction of late adverse effects (i.e. neurological and endocrine disorders), whereas patients belonging to the high-risk group (i.e. such owning MYC amplification; 5-year survival 13 %) urgently need a more intensive therapy to improve survival. In the present study, we analyzed RV-mediated changes on the clonogenic survival and proliferation of irradiated medulloblastoma cells. Furthermore, we investigated if RV may induce double-strand breaks (DSB), and if combined RV/irradiation (IR) treatment affects the number of potential tumor stem cells (TSC). METHODS: Three MB cell lines were treated with RV doses ranged from 9.5 µM to 40 µM (based on preliminary experiments examining metabolic activity or clonogenic survival of each cell line) for three or six days. 2 Gy IR was applied immediately before RV (3 d treatment) or after three days (6 d treatment). Clonogenic assays were conducted at the end of treatment time. DSB were measured by γH2AX assay 1 h and 24 h after IR or RV. To quantify potential TSC, we detected vital CD15+ and CD133+ cells by flow cytometry three days after IR and RV treatment. Effects on proliferation were measured flow cytometrically in CSFE-labeled cells. RESULTS: The post-treatment of irradiated MB cells with RV for three days significantly decreased the clonogenic survival 1.8-fold (DAOY) to 36-fold (MEB-Med8a). The longer RV treatment period reached stronger effects decreasing the clonogenic survival by up to 900-fold in irradiated D283-Med cells. Both, IR and RV alone, induced DSB. An increase of residual, unrepaired IR-induced DSB was observed after RV treatment in two-out-of-three MB cell lines (DAOY, MEB-Med8a). Examining the number of potential TSC, we revealed an enrichment of CD15+ and CD133+ cells after RV or IR alone, which was slightly enhanced by combination of both. We found no differences in proliferation rates between TSC and non-TSC. Therefore, we assume that the enrichment of TSC is caused by a higher treatment resistance of potential TSC compared to non-TSC. CONCLUSION: RV may enhance the radiation effects on clonogenic survival of human MB cells, possibly through an increased induction of additional DSB. Further studies in animal MB models are warranted to clarify if the observed in vitro effects translate into improved survival rates in vivo.
CORRELATION OF COREVALVE IMPLANTATION ‘TRUE COVER INDEX’ WITH SHORT AND MID-TERM AORTIC REGURGITATION: IMPLANTATION DEPTH REALLY MATTERS
Authors: Manolis Vavuranakis, Konstantinos Kalogeras, Myrsini Stasinopoulou, Mary Lavda, Abgelos-Michail Kolokathis, Dimitrios Vrachatis, Maria Kariori, Carmen Moldovan, Evangelia Bei, Sophia Vaina, Gerasimos Siasos, Evangelos Oikonomou, Dimitris Tousoulis
Journal: Journal of the American College of Cardiology (2016)
Donors should be tougher on poor countries that don't engage in health programmes
Authors: R. Coombes
Journal: BMJ (2011)

Donor agencies could be doing “more harm than good” by fully funding disease programmes in low income countries without expecting governments to make any financial contribution, a conference on global health has heard.

Speaking at the Global Health 2011 conference at the BMA in London, David Heymann, chairman of the UK Health Protection Agency, said, “Agencies need to be strong enough to say, ‘We are going to make you sweat’ [for the funding]. Recipient countries need to play a greater role in procurement. Why can’t some of the African countries who can afford it be buying the …