tbuckley/cabot-search huggingface dataset:
OC-071 Dysphagia Patients with Normal Oesophageal High Resolution Manometry: Assessing The Diagnostic Value of Bread Swallows
Authors: I Miah, T Orton, G Sui, T Wong, J Jafari
Journal: Gut (2016)

<h3>Introduction</h3> High resolution manometry (HRM) is currently the gold standard technique to investigate oesophageal motility in patients with dysphagia. However, with routine HRM procedure and use of Chicago classification, a group of patients with dysphagia are considered as being normal and dysphagia remains unexplained. The aim of this study is to assess the diagnostic value of solid bolus swallows in patients with dysphagia and normal HRM. <h3>Methods</h3> Patients having dysphagia and normal HRM studies during January-October 2015 were selected. Solid bolus swallows of bread (1cm<sup>3</sup> single bread swallows and/or a sandwich meal) followed the routine water swallows on HRM. Patients with a double high pressure zone, oesophageal diverticulum or history of antireflux surgery were excluded. The patients were categorised to symptomatic and asymptomatic groups based on having dysphagia reproduced on bread swallows. Hospital odynophagia and dysphagia questionnaire (HODQ) score, integrated relaxation pressure (IRP), distal contractile integration (DCI), distal latency (DL) and peristaltic abnormality during water swallows were investigated and compared between groups. ROC curve was used to identify the optimum level of sensitivity and specificity of the significant parameters in identifying patients who have a meaningful abnormality on bread swallows. Student t-test is used to compare significance of differences. P value &lt;0.05 was considered as significant. <h3>Results</h3> 72 patients referred with dysphagia and diagnosed with normal HRM were selected. In the asymptomatic group, 7/22 patients showed abnormality on bread swallows and in the symptomatic group, 45/50 showed abnormal motility (P = 0.0001). ROC analysis showed that having &gt;33.3% abnormal bread swallows has sensitivity of 72%, specificity of 90.91% and likelihood ratio of 7.9 to detect patients who may have abnormal motility and dysphagia on bread swallows. Analysis of water swallow parameters comparing the asymptomatic group against the symptomatic group with abnormal motility on bread swallows did not reveal any significant difference in HODQ score (P = 0.2), IRP (P = 0.17), DL (P = 0.3) and peristaltic abnormalities (P = 0.4). <h3>Conclusion</h3> Performing solid swallows on HRM can explain dysphagia in a considerable number of patients with dysphagia and normal routine HRM. This complementary test is readily available, and avoids the need for Barium swallowing and radiation exposure. <h3>Disclosure of Interest</h3> None Declared
Human Monoclonal Antibodies to TRAIL Receptors R1 and R2 Effectively Induce Apoptosis in Human Myeloma Cells.
Authors: Shuji Ozaki, Etsuko Sekimoto, Yoichi Tanaka, Takashi Ohshima, Hironobu Shibata, Toshihiro Hashimoto, Masahiro Abe, Kazuhiro Motoki, Isao Ishida, Shiro Kataoka, Toshio Matsumoto
Journal: Blood (2004)
Klippel–Trenaunay syndrome: endoscopic findings
Authors: Sandra Barbeiro, Rita Brásio, Catarina Atalaia-Martins, Pedro Marcos, Cláudia Gonçalves, Paulo Alves, Nuno Rama
Journal: Endoscopy (2016)

A 44-year-old man with no relevant past medical history was referred for colonoscopy because of recurrent hematochezia and iron deficiency anemia. He reported no abdominal pain or weight loss. He had been on oral therapy with ferrous sulfate. A hypertrophic lower left limb was seen on physical examination. Colonoscopy ([Video 1]) revealed ectasia and congestion of the submucosal and mucosal vessels and hemangiomas with a continuous pattern, affecting the rectum and the left colon, with normal vessels in the transverse colon ([Fig. 1]). These vascular lesions were not bleeding actively at the time of endoscopy, but were the likely cause of the gastrointestinal bleeding.
FRI0410 Ultrasonic Follow Up Half A Year Etanercept Treatment for Early Spondyloarthropathy Induced Peripheral Enthesitis
Authors: D.F. Lin, M.J. Zhao, J.Y. Cao, J.R. Gu
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Mardird sonographic enthesis index (MASEI) was one of the most wide used scoring systems for peripheral enthesitis. A report ever observed the efficacy of Sulfasalazine for peripheral enthesitis in Ankylosing Spondylitis. However, no reports followed up biological agents treatment for early axial spondyloarthropathy (SpA) by MASEI method so far. <h3>Objectives</h3> Our study is to find out whether MASEI is suitable for accurately reflecting the therapy effect of biological agents like Etanercept for early axial SpA. <h3>Methods</h3> Ultrasound was performed by 2 observers blinded to the other examinations and the final diagnosis once per 3-months and it is planned to carry on for a year. All cases were diagnosed as early axial SpA fulfilling 2009 classification criteria but not 1996 New York Criteria with sacroilliac X-ray and MRI.US examination referred to MASEI related regions. The count of swollen joint, the count of tender joints, ESR, CRP, PGA, PhGA, BASDI, BASFI, BASMI, MASES, ASDAS were employed to assess disease activity. <h3>Results</h3> 1) 95 early axial SpA subjects were finally enrolled in the program. All of them finished 24-week follow up, and 33 of them finished 48-week follow up until now. Mean age was 25.0±5.9 years old, female-male ratio was 0.48:1, and disease duration was 36.3months. Only 2 were negative HLA-B27. 2) The response for Etanercept was pretty good with the evidence of all the indexes above had prominent progress both in 12 week and 24 week except the count of swollen joint between 0w and 12w (paired Wilcoxon test, sig&lt;0.05) 3) The good response for Etanercept was also well reflected by the ultrasonic scores: average sum scores (0w:12w:24w = 26.51:13.57:9.57,), tendon thickness scores (0w:12w:24w = 0.88:0.50:0.58, 12w:24w sig=0.11), structure disturbance scores (0w:12w:24w = 5.94:3.13:2.04), bone erosion scores (0w:12w = 6.49:6.52:6.42), calcification scores (0w:12w:24w = 6.45:3.09:1.98), bursitis scores (0w:12w:24w = 1.44:0.46:0.30), Power Doppler scores (0w:12w:24w = 5.32:1.87:1.25). All the scores above were significantly decreased except tendon thickness score between 12week and 24week and bone erosion scores during half a year. 4) There are no correlations between US scores and all the disease activity indexes at baseline, 12 week or 24 week visit point in early axial SpA perhaps due to the peripheral enthesitis might not reflect the axial circumstance. <h3>Conclusions</h3> Though the trial was still carried on for the last half a year, our study proved MASEI assessment is a good tool to supervise the effect of Etanercept for peripheral enthesitis in early SpA. <h3>Disclosure of Interest</h3> None declared
Outcomes and Treatments of Relapsed AL Amyloidosis Following Stem Cell Transplant
Authors: Rahma Warsame, Soo-Mee Bang, Shaji K. Kumar, Martha Q Lacy, Francis K Buadi, David Dingli, Suzanne R Hayman, John A Lust, Stephen Russell, Thomas E. Witzig, Robert A. Kyle, Nelson Leung, Steven R Zeldenrust, S. Vincent Rajkumar, Morie A Gertz, Angela Dispenzieri
Journal: Blood (2012)
Aplidin Cardiac Safety Analysis.
Authors: Arturo Soto-Matos, Sergio Szyldergemajn, Javier Gomez, Sonia Extremera, Bernardo Miguel-Lillo, Vicente Alfaro, Cinthya Coronado, Pilar Lardelli, Elena Roy, Claudia S. Corrado, Alejandro Yovine, Carmen Kahatt
Journal: Blood (2009)
Thiazide diuretics seem to protect against fracture
Authors: Jacqui Wise
Journal: BMJ (2016)

Thiazide diuretics are associated with a reduced risk of hip and pelvic fractures compared with treatment with other antihypertensive drugs, according to a randomised trial reported in JAMA Internal Medicine .1

The secondary analysis of the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) found a 21% lower risk of hip and pelvic fractures associated with chlorthalidone compared with either …
Calcitonin A Genotype Is Associated with Risk of Acute Graft-Versus-Host Disease Following Allogeneic Bone Marrow Transplantation for Children with Acute Myeloid Leukemia in First Remission.
Authors: Rakesh K. Goyal, Liane Fairfull, Robert B. Gerbing, Todd A. Alonzo4, Soheil Meshinchi4, Beverly J. Lange4, William J. Woods4, Robert E. Ferrell
Journal: Blood (2005)
Expanding Payment Reform in Medicare
Authors: Zirui Song, Daniel M. Blumenthal
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
FRI0289 Multicenter Registry on Inflammatory Myopathies in Madrid (REMICAM): Mortality Analysis
Authors: L. Nuño, M.J. García, B. Joven, V. Maldonado, I. Llorente, C. Barbadillo, P. García de la Peña, L. Ruiz, H. Moruno, T. Cobo, R. Almodovar, L. Lojo, F.J. Lόpez Longo
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Classically the prognosis of idiopathic inflammatory myopathies (IIM) has improved in recent decades, but can still be poor in certain subgroups or in the presence of some clinical factors. <h3>Objectives</h3> To analyze survival, causes of death and poor prognosis factors in a cohort of patients diagnosed with IIM. <h3>Methods</h3> A multicenter retrospective study from REMICAM<sup>1</sup> myositis study group was performed. All patients were diagnosed with IIM according to Bohan and Peter<sup>2</sup> criteria and were classified into 5 different clinical subgroups: primary dermatomyositis (DM), primary polymyositis (PM), juvenile dermatomyositis (JuvM), cancer associated myositis (CAM) and overlap myositis (OM). <h3>Results</h3> 478 IIM cases were included. 74% of the cases were women, with an age at diagnosis of 43.7±22.6 ys. and a mean follow-up of 9.7±8.3 ys. During the follow-up period there were a total of 114 deaths (24%), the main causes were infections (24%), cancer (24%), and cardiovascular events (22%). Factors associated with poor prognosis were CAM (HR 15.4) and OM subgroups (HR 4.55), older age at diagnosis (HR 1.05), shorter time of disease (HR 1.30), serious infections (HR 4.57), cancer (HR 3.07), systemic symptoms (HR 1.64), heart (HR 2.52) and haematological manifestations (HR 1.53), ESR/CRP elevation at baseline (HR 3.05) and chronic renal failure (HR 2.41). The clinical characteristics that showed a protective effect were arthralgia (HR 0.68), typical skin lesions (HR 0.62), drug use (HR 0.53) and female sex (HR 0.5). In multivariate analysis the independent variables associated with mortality were CAM (HR 8.83) and OM (HR 5.17) subgroups, severe infections (HR 3.42), older age at diagnosis (HR 1.03), shorter course of the disease (HR 1.34), thrombocytopenia (HR 2.93) and elevated ESR/CRP (HR 2.47). <h3>Conclusions</h3> In our REMICAM registry on inflammatory myopathies 24% of patients died, mainly due to infections, cancer and cardiovascular events. The independent predictors of mortality were belonging to the subgroups of paraneoplastic myopathies or overlap syndrome, the presence of severe infections, thrombocytopenia, elevated ESR/CRP at baseline, shorter course of the disease and older age at onset. <h3>References</h3> REMICAM: Registry on inflammatory myopathies in Madrid Bohan A, Peter JB. N Engl J Med 1975 Feb 13;292(7):344–7. <h3>Disclosure of Interest</h3> L. Nuño Grant/research support from: SORCOM-MSD grant for myositis study, M. J. García: None declared, B. Joven: None declared, V. Maldonado: None declared, I. Llorente: None declared, C. Barbadillo: None declared, P. García de la Peña: None declared, L. Ruiz: None declared, H. Moruno: None declared, T. Cobo: None declared, R. Almodovar: None declared, L. Lojo: None declared, F. J. Lόpez Longo: None declared
Association Between Genetic Polymorphism in DNA Repair Genes and Acute Myeloid Leukemia.
Authors: Hee Nam Kim, Nan young Kim, Li Yu, Huong Thi Thanh Tran, Yeo-Kyeoung Kim, Il-Kwon Lee, Deok-Hwan Yang, Je-Jung Lee, Hee-Je Kim, Woo-Sung Min, Moo-Rim Park, Deog Yeon Jo, Jong Ho Won, Jae-Yong Kwak, Hyeoung-Joon Kim
Journal: Blood (2009)
Treatment with Ruxolitinib (INCB018424) Induced Changes of Microrna Expression in Granulocytes of Patients with Polycythemia Vera and Essential Thrombocythemia,
Authors: Paola Guglielmelli, Lisa Pieri, Enrico Tagliarico, Roberta Zini, Ruggiero Norfo, Alberto Bosi, Kris Vaddi, Timothy Burn, Nancy Contel, Srdan Verstovsek, Rossella Manfredini, Alessandro M. Vannucchi
Journal: Blood (2011)
Use of endoscopic septotomy for the treatment of late staple-line leaks after laparoscopic sleeve gastrectomy
Authors: Mati Shnell, Nathan Gluck, Subhi Abu-Abeid, Erwin Santo, Sigal Fishman
Journal: Endoscopy (2016)

<b>Background</b> Staple-line leak following laparoscopic sleeve gastrectomy is a dire adverse event. While the treatment of acute and early leaks is well established, there is still dispute regarding late and chronic leaks. We describe an endoscopic approach combining septotomy and sleeve stricture dilation for treating late/chronic leaks. <b>Methods</b> Ten consecutive patients with late/chronic proximal leaks were treated at our center. The septum separating the sleeve lumen from the perigastric cavity was progressively dissected over several sessions and the downstream stricture was pneumatically dilated. The technical and clinical success rates were evaluated. <b>Results: </b>All ten patients were treated successfully. Eight patients had sleeve strictures that were dilated in conjunction with septotomy. A mean of five sessions over the course of 43 days was needed to complete treatment. In two patients with a small perigastric cavity and no stricture, septotomy was achieved with through-the-scope balloon dilation of the fistula. No adverse events were encountered. <b>Conclusions</b> Septotomy accompanied by stricture dilation seems highly effective and safe in late and chronic leaks following sleeve gastrectomy.
Intensive vs Standard Blood Pressure Control for Older Adults
Authors: Christopher Karayiannis, Thanh G. Phan, Velandai Srikanth
Journal: JAMA (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
OP0031 Risk Factors for Malignancies Synchronous To The Onset of Systemic Sclerosis in Patients Positive for Anti- RNA Polymerase III Antibodies: A Eustar Multicentre Study
Authors: M.G. Lazzaroni, I. Cavazzana, E. Colombo, O. Distler, R. Dobrota, J. Hernandez, R. Hesselstrand, L. Czirjak, C. Varju, G. Nagy, V. Smith, P. Caramaschi, V. Riccieri, E. Hachulla, K. Romanowska-Prochnicka, A. Balbir-Gurman, E. Chatelus, A.C. Araùjo, Y. Allanore, P. Airò
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Patients with anti-RNA polymerase III antibodies (anti-RNAP) have an increased risk of malignancies synchronous to the onset of Systemic Sclerosis (SSc). In a multicentre EUSTAR case-control study, however, only moderate odd ratio was observed (OR 3.85, 95%CI 1.3–10.9), except than for breast cancer (OR 20.2, 95%CI 1.4–355) (1). Defining clinical and demographic features characteristic of anti-RNAP+ SSc patients who suffer from simultaneous malignancy would be useful to individuate risk factors who can guide the clinicians in every-day practice to screen anti-RNAP+ SSc patients for cancer. <h3>Objectives</h3> To individuate risk factors for malignancies synchronous to the onset of SSc in anti-RNAP+ patients. <h3>Methods</h3> EUSTAR centers were asked to participate to this study, providing data on malignancy history of their anti-RNAP+ patients in a dedicated form. <h3>Results</h3> Among 158 anti-RNAP+ SSc patients collected from 13 EUSTAR centers, 14 cases of malignancies synchronous to the onset of SSc were identified. When compared with the other 144 anti-RNAP+ patients, patients with synchronous malignancies had an older mean age at SSc onset (65.3 yrs (SD 10.0) vs 49.3 (SD13.3); p&lt;0.001) and an increased proportion of diffuse cutaneous subset (96% vs 56%; p:0.008; OR: 10.5 95%CI 1.33–82.6). A trend for increased proportion of males was also observed (43% vs 21%; p:0.06). In particular, the risk of non-breast cancer synchronous with SSc was greatly higher in male than in female patients (43% vs. 0.8%; p&lt;0.001; OR 95.2 95%CI 10.2–890). <h3>Conclusions</h3> Anti-RNAP+ SSc patients of older age, and with diffuse cutaneous subset, are particularly at risk for malignancies synchronous to the onset of SSc. The risk of malignancies other than breast cancers is greatly increased in male patients. These risk factors may help in the screening for cancer in these patients. <h3>References</h3> M.G. Lazzaroni et al. Anti-RNA Polymerase III Antibodies in Patients with Systemic Sclerosis: A Eustar Multicenter Collaborative Study. Ann Rheum Dis 2015;74:Suppl 2 88 doi:10.1136/annrheumdis-2015-eular.1728 <h3>Disclosure of Interest</h3> None declared
A Significant Fraction of ADAMTS13 Activity Is Associated with Activated Platelets and Their Microparticles (PMP): Implication for Regulating ADAMTS13 Activity.
Authors: Wenche Jy, Andrew Lin, Loreta Bidot, Jaehoon Bang, Eugene Ahn, Lawrence L. Horstman, Joaquin J. Jimenez, Carlos J. Bidot, Yeon-Soong Ahn
Journal: Blood (2006)
Apolipoprotein Α-IV Is a Novel Ligand of Platelet αIIbβ3 Integrin and an Endogenous Thrombosis Inhibitor: Measurement of Single-Molecular Interactions By Biomembrane Force Probe
Authors: Xiaohong Xu, Christopher M. Spring, Lining Ju, Yiming Wang, Adili Reheman, Hong Yang, Joseph Wuxun Jin, Xi Lei, Yan Yang, Emily C. Reddy, Yunfeng Chen, Pingguo Chen, Guangheng Zhu, Patrizia Marchese, Alessandro Zarpellon, Hailong Zhang, YiMin She, Terry Cyr, Cheng Zhu, John Freedman, Patrick Tso, Sean Davidson, Zaverio M. Ruggeri, Heyu Ni
Journal: Blood (2014)
SP0024 Type I Interferonopathies
Authors: Y. Crow
Journal: Annals of the Rheumatic Diseases (2016)

Dissection of the genetic basis of Aicardi-Goutières syndrome has highlighted a fundamental link between nucleic acid metabolism and type I interferon induction, leading to the concept of the human interferonopathies, a broader set of Mendelian disorders where disease pathology relates to a primary upregulation of type I interferon activity. Here we discuss the clinical phenotypes associated with these novel inborn errors of immunity, their pathological basis, and strategies for their treatment. <h3>Disclosure of Interest</h3> None declared
Molecular Classification of Bone Marrow Failure Syndromes: Protein Signatures As Surrogate Biomarker for Accurate Diagnosis of Severe Aplastic Anemia, Hypoplastic Myelodysplastic Syndrome and Paroxysmal Nocturnal Hemoglobinuria Patients
Authors: Ayodele Alaiya, Hazza A Alzahrani, Zakia Shinwari, Tarek Owaidah, Fahad Al Mohareb, Fahad Al Sharif, Randa Al Nounou, Naeem A. Chaudhri, Ghuzayel Aldawsari, Amr Hanbali, Marwan Shaheen, Feras Alfraih, Syed Osman Ahmed, Mahmoud Aljurf
Journal: Blood (2015)
Open Wards in Psychiatric Clinics and Compulsory Psychiatric Admissions—Reply
Authors: Mark H. de Jong, Astrid M. Kamperman, Cornelis L. Mulder
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal