tbuckley/cabot-search huggingface dataset:
First World Conference on Medical Education
Authors: L H BAUER
Journal: BMJ (1953)

One of the aims of the World Medical Association is the improvement of medical education. At the fourth General Assembly of the association in New York, in 1950, preliminary thought was given to the holding of the first World Conference on Medical Education. At the fifth General Assembly in Stockholm in 1951, it was definitely determined to hold such a conference. To quote Dr. Hugh Clegg, 1 the editor of the British Medical Journal , After all, medical education is fundamental to our professional life and work. Without medical education the people of the world would still be at the mercy of the witch-doctor and the cultist; many of them, of course, still are. Perhaps it is because the subject is so vast that doctors have so far fought shy of staging an international discussion on it.  Again Dr. Clegg 1 said, Now, then is the time to take stock. Medicine,
Abstract P6-03-19: Rs1008805 polymorphism in the CYP19A1 gene is related to the prognosis of stage I–II and operable stage III breast cancer
Authors: X Shao, Y Zheng, L Shi, Y Huang, X Wang
Journal: Cancer Research (2016)

Abstract Purpose Aromatase, encoded by CYP19A1 gene, is a rate-limiting enzyme in the conversion of androgens into estrogens. It has been demonstrated that genetic polymorphisms in CYP19A1 gene were significantly correlated with altered hormone levels in urine and serum, providing an explication for an elevated risk for progression in relation with increasing estrogen exposure. Consequently, it is biologically plausible that CYP19A1 gene polymorphisms may be related to the prognosis of breast cancer. Methods CYP19A1 gene rs1008805 polymorphism were genotyped on 406 Chinese Han women with stage I-II and operable stage III breast cancer. Associations were evaluated between CYP19A1 rs1008805 genotypes and disease-free survival (DFS). Results Totally, there were 200 (49.3%) patients with AA genotype, 169 (41.6%) with AG variant, and 37 (9.1%) carrying GG variant. No significant differences were found in DFS among the whole population with these three genotypes. However, postmenopausal women with GG variant had a poorer DFS when compared with those carrying AG or AA genotype (13.7 months versus 56.3 months; HR, 2.462; 95 % CI, 1.310-4.628; P = 0.004). And what's more, being adjusted by patients features in multivariate analyses, GG genotype remained an independent prognostic factor for DFS (HR, 2.706; 95 % CI, 1.393-5.257; P = 0.003). Premenopausal women with GG variant had a marginally improved DFS when compared with those carrying AG or AA genotypes (87.0 months versus 48.7 months; HR, 0.544; 95% CI, 0.295-1.003; P = 0.051). However, this difference was not confirmed by multivariate analyses. Conclusions The present study indicated that GG genotype of rs1008805 SNP in the first exon of CYP19A1 gene was significantly related to a worse DFS in postmenopausal women with early breast cancer. This founding is novel, if confirmed, CYP19A1 rs1008805 genotypes may turn to be a prognostic biomarker for early breast cancer. Citation Format: Shao X, Zheng Y, Shi L, Huang Y, Wang X. Rs1008805 polymorphism in the CYP19A1 gene is related to the prognosis of stage I–II and operable stage III breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P6-03-19.
Reply: Risk Factors for Deep Venous Thrombosis of the Upper Extremities
Authors: Ida Martinelli
Journal: Annals of Internal Medicine (1997)

Letters15 December 1997Reply: Risk Factors for Deep Venous Thrombosis of the Upper ExtremitiesIda Martinelli, MD, Marco Cattaneo, MD, and Pier Mannuccio Mannucci, MDIda Martinelli, MDIRCCS Ospedale Maggiore; Milano, ItalySearch for more papers by this author, Marco Cattaneo, MDIRCCS Ospedale Maggiore; Milano, ItalySearch for more papers by this author, and Pier Mannuccio Mannucci, MDIRCCS Ospedale Maggiore; Milano, ItalySearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-127-12-199712150-00019 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Pandita and colleagues suggest that patients with unusual sites of venous thrombosis, such as the upper extremities, should be screened for factor XII deficiency, which they consider to be a rare but important cause of thrombophilia. In our study, we showed that the prevalence of several causes of thrombophilia is not increased in patients with deep venous thrombosis of the upper extremities; the most frequent and important risk factor for this condition is a recent history of strenuous exercise of muscles of the affected extremity. In light of our findings, thrombophilic states of any kind should not be ...References1. von Kanel R, Wuillemin WA, Furlan M, Lammle B. Factor XII clotting activity and antigen levels in patients with thromboembolic disease. Blood Coagul Fibrinolysis. 1992; 3:555-61. Google Scholar2. Lammle B, Wuillemin WA, Huber I, Krauskopf M, Zurcher C, Pflugshaupt R, et al. Thromboembolism and bleeding tendency in congenital factor XII deficiency. A study on 74 subjects from 14 Swiss families. Thromb Haemost. 1991; 65:117-21. Google Scholar3. Rodeghicro F, Castaman G, Ruggeri M, Tosetto A. Thrombosis in subjects with homozygous and heterozygous factor XII deficiency. Thromb Haemost. 1992; 67:590. Google Scholar4. Winter M, Gallimore M, Jones DW. Should factor XII assay be included in thrombophilia screening? [Letter] Lancet. 1995; 346:52. Google Scholar Author, Article, and Disclosure InformationAffiliations: IRCCS Ospedale Maggiore; Milano, Italy PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 December 1997Volume 127, Issue 12Page: 1129KeywordsAnticoagulantsBlood plasmaDeep vein thrombosisMedical risk factorsMusclesPartial thromboplastin timeStrenuous exercise Issue Published: 15 December 1997 CopyrightCopyright © 1997 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...
Final results of the second prospective AIEOP protocol for pediatric intracranial ependymoma
Authors: Maura Massimino, Rosalba Miceli, Felice Giangaspero, Luna Boschetti, Piergiorgio Modena, Manila Antonelli, Paolo Ferroli, Daniele Bertin, Emilia Pecori, Laura Valentini, Veronica Biassoni, Maria Luisa Garrè, Elisabetta Schiavello, Iacopo Sardi, Armando Cama, Elisabetta Viscardi, Giovanni Scarzello, Silvia Scoccianti, Maurizio Mascarin, Lucia Quaglietta, Giuseppe Cinalli, Barbara Diletto, Lorenzo Genitori, Paola Peretta, Anna Mussano, Annamaria Buccoliero, Giuseppina Calareso, Salvina Barra, Angela Mastronuzzi, Carlo Giussani, Carlo Efisio Marras, Rita Balter, Patrizia Bertolini, Ermanno Giombelli, Milena La Spina, Francesca R Buttarelli, Bianca Pollo, Lorenza Gandola
Journal: Neuro-Oncology (2016)

This prospective study stratified patients by surgical resection (complete = NED vs incomplete = ED) and centrally reviewed histology (World Health Organization [WHO] grade II vs III). WHO grade II/NED patients received focal radiotherapy (RT) up to 59.4 Gy with 1.8 Gy/day. Grade III/NED received 4 courses of VEC (vincristine, etoposide, cyclophosphamide) after RT. ED patients received 1–4 VEC courses, second-look surgery, and 59.4 Gy followed by an 8-Gy boost in 2 fractions on still measurable residue. NED children aged 1–3 years with grade II tumors could receive 6 VEC courses alone. From January 2002 to December 2014, one hundred sixty consecutive children entered the protocol (median age, 4.9 y; males, 100). Follow-up was a median of 67 months. An infratentorial origin was identified in 110 cases. After surgery, 110 patients were NED, and 84 had grade III disease. Multiple resections were performed in 46/160 children (28.8%). A boost was given to 24/40 ED patients achieving progression-free survival (PFS) and overall survival (OS) rates of 58.1% and 68.7%, respectively, in this poor prognosis subgroup. For the whole series, 5-year PFS and OS rates were 65.4% and 81.1%, with no toxic deaths. On multivariable analysis, NED status and grade II were favorable for OS, and for PFS grade II remained favorable. In a multicenter collaboration, this trial accrued the highest number of patients published so far, and results are comparable to the best single-institution series. The RT boost, when feasible, seemed effective in improving prognosis. Even after multiple procedures, complete resection confirmed its prognostic strength, along with tumor grade. Biological parameters emerging in this series will be the object of future correlatives and reports.
Cardiac sinus node dysfunction during lithium treatment
Authors: S P Roose, J I Nurnberger, D L Dunner, D K Blood, R R Fieve
Journal: American Journal of Psychiatry (1979)

Lithium treatment has been associated with a wide range of cardiac complications. The authors report three additional cases of cardiac sinus node dysfunction due to lithium. Two of the three cases were documented to be lithium dependent by the use of Holter monitoring of cardiac rhythm. On the basis of this finding as well as other reports in the literature the authors recommend careful monitoring of the pulse of patients taking lithium as well as ECG monitoring of patients who are over the age of 50 or who have a history of cardiac disease.
Treatment Options for Veterans With Posttraumatic Stress Disorder
Authors: Barbara O. Rothbaum
Journal: JAMA Psychiatry (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Relation Between Genotype and Left-Ventricular Dilatation in Patients With Marfan Syndrome
Authors: Peter Van Tintelen, Lilian J. Meijboom, Jan D. Jongbloed, Gerard Pals, Janneke Timmermans, Julie de Backer, Robert M. Hofstra, Barbara J. Mulder, Maarten P. van den Berg
Journal: Circulation (2009)
Covalent Binding to Protein of the K-Region Oxide of Benzo[a]pyrene Formed by Microsome Incubation2
Authors: C. R. Raha, C. H. Gallagher, P. Shubik, S. Peratt
Journal: JNCI Journal of the National Cancer Institute (1976)

Incubation of 20,000 × g supernatant proteins of rat liver with benzo[a]pyrene (BP) and appropriate cofactors produced metabolites of BP covalently bound at the 4,5- position to protein. After being incubated, protein samples were freed from noncovalently bound metabolites and hydrolyzed chemically or both enzymatically and chemically. All steps were performed under minimum exposure to light and air; benzene extracts were prepared during hydrolysis. Chemical hydrolysis released the K-region metabolite BP-4,5-dihydrodiol (identified by UV and mass spectra) and BP. Hydrolysis with trypsin and pronase gave products with the characteristic UV spectrum of substituted chrysene. Chemical hydrolysis of these products released BP and BP-4,5-dihydrodio.
Dynamic Changes in Renal Function Are Associated With Major Cardiovascular Events in Patients With Type 2 Diabetes
Authors: Stéphanie Ragot, Pierre-Jean Saulnier, Gilberto Velho, Elise Gand, Astrid de Hauteclocque, Yousri Slaoui, Louis Potier, Philippe Sosner, Jean-Michel Halimi, Philippe Zaoui, Vincent Rigalleau, Frederic Fumeron, Ronan Roussel, Michel Marre, Samy Hadjadj
Journal: Diabetes Care (2016)

The pattern of renal function decline prior to cardiovascular (CV) events in type 2 diabetes is not well known. Our aim was to describe the association between renal function trajectories and the occurrence of a CV event.We considered patients with type 2 diabetes from the SURDIAGENE (Survie, Diabete de type 2 et Genetique) study (discovery cohort) and the DIABHYCAR (Non-Insulin-Dependent Diabetes, Hypertension, Microalbuminuria or Proteinuria, Cardiovascular Events, and Ramipril) study (replication cohort). Global patterns of estimated glomerular filtration rate (eGFR) (Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI]) and serum creatinine (SCr) prior to a major CV event (MACE) or last update were determined using a linear mixed-effects model and annual individual slopes computed by simple linear regression.In the 1,040 participants of the discovery cohort, establishment of global patterns including 22,227 SCr over 6.3 years of follow-up showed an annual eGFR decline and an annual SCr increase that were significantly greater in patients with MACE compared with patients without (-3.0 and -1.7 mL/min/1.73 m(2)/year and +10.7 and +4.0 μmol/L/year, respectively; P < 0.0001 for both). Median annual individual slopes were also significantly steeper in patients with MACE, and adjusted risk of MACE was 4.11 times higher (3.09-5.45) in patients with rapid decline in eGFR (change less than -5 mL/min/1.73 m(2)/year). Consideration of renal function trajectories provided significant additive information helping to explain the occurrence of MACE for both SCr and eGFR (PIDI < 0.0001 and P = 0.0005, respectively). These results were confirmed in the replication cohort.Renal function decline was associated with a higher risk of MACE. The pattern of renal function decline, beyond baseline kidney function, is an independent factor of CV risk.
Vaccination Against Smallpox
Authors: C. W. Dixon
Journal: BMJ (1962)

No immunization procedure is of advantage in itself.Vaccination can have value only when there is a finite risk of smallpox and it is weighed against the risk of complications of the procedure.Used the right way and having regard to its limitations, vaccination is one of the soundest operations in preventive medicine.Jenner believed that vaccination always gave lifelong immunity, which is quite untrue, and many who followed him believed that every vaccinated person always had an advantage over the unvaccinated-but this also is not true.A vaccinated person, particularly one vaccinated in infancy, may well die of smallpox or have a severe unmodified attack.Although previous vaccination may not give an individual any advantage, a group of vaccinated persons will suffer a lower mortality rate than an unvaccinated group.logical control posts at seaports and airports, and(2) to ensure that the traveller is immunized sufficiently BRn
Prevalence of Doctor-Diagnosed Arthritis at State and County Levels — United States, 2014
Authors: Kamil E. Barbour, Charles G. Helmick, Michael Boring, Xingyou Zhang, Hua Lu, James B. Holt
Journal: MMWR Morbidity and Mortality Weekly Report (2016)

Doctor-diagnosed arthritis is a common chronic condition that affects approximately 52.5 million (22.7%) adults in the United States and is a leading cause of disability (1,2). The prevalence of doctor-diagnosed arthritis has been well documented at the national level (1), but little has been published at the state level and the county level, where interventions are carried out and can have their greatest effect. To estimate the prevalence of doctor-diagnosed arthritis among adults at the state and county levels, CDC analyzed data from the 2014 Behavioral Risk Factor Surveillance System (BRFSS). This report summarizes the results of that analysis, which found that, for all 50 states and the District of Columbia (DC) overall, the age-standardized median prevalence of doctor-diagnosed arthritis was 24% (range = 18.8%-35.5%). The age-standardized model-predicted prevalence of doctor-diagnosed arthritis varied substantially by county, with estimates ranging from 15.8% to 38.6%. The high prevalence of arthritis in all counties, and the high frequency of arthritis-attributable limitations (1) among adults with arthritis, suggests that states and counties might benefit from expanding underused, evidence-based interventions for arthritis that can reduce arthritis symptoms and improve self-management.
Case of whistleblower whose career was “destroyed” prompts review of law
Authors: Clare Dyer
Journal: BMJ (2016)

The UK government has promised to look again at a gap in whistleblower protection for junior doctors, after a judgment of the Employment Appeal Tribunal in March laid bare a gap in the law.

The appeal tribunal threw out a case brought by the junior doctor Chris Day, who claimed that Health Education England (HEE), the body that oversees the training of doctors in England, treated him unfairly and destroyed his career after he questioned serious understaffing at Lewisham and Greenwich NHS Trust, where he was working.

Mr Justice Langstaff ruled that HEE, although it arranges junior doctors’ training placements, pays a substantial part of their salary, and reviews their progress in training, does not employ them …
Early influenza in Europe and SARS escaping from high security laboratories !
Authors: J C Desenclos
Journal: Eurosurveillance (2003)

In this issue, Radun et al report a retrospective investigation of SARS in 21 German guests who stayed at Hotel 'M' in Hong Kong between 21 February and 3 March 2003 (1). They were able to identify retrospectively an unrecognized case of SARS in a patient who stayed on the ninth floor on the night of 21-22 February (the same floor as the symptomatic physician who had acquired SARS in Guangdong province, China).
What Brexit would mean for employment of doctors
Authors: Anne Gulland
Journal: BMJ (2016)

Anne Gulland assesses how leaving the EU would affect working conditions

The European Working Time Directive is the key piece of European Union legislation affecting doctors’ working hours, limiting the working week to 48 hours. The regulations were implemented in 1998, but all junior doctors were not included until 2009.

Some specialties, particularly surgeons, have been concerned that the 48 hour week limits training. Doctors can opt out of the 48 hour limit, and a Royal College of Surgeons (RCS) review of the directive called for more widespread use of the opt-out.1 The UK is one of the few EU countries to use the opt-out.

Jason Heyes, professor of employment relations at the University of Sheffield, believes that the working time regulations, the UK law enacting the EU directive, is one of the employment laws most likely to be repealed or reformed if we leave the EU.

“The regulations are a particular bugbear as they’re seen by many Conservative politicians as an unnecessary and damaging burden …
Ergometrine with Hyaluronidase
Authors: A. H. Labrum
Journal: BMJ (1958)

Uterine anomalies are relatively uncommon and go undiagnosed in many cases. Ectopic pregnancies have been reported in such patients, although rarely, in the non-communicating rudimentary horns of unicornuate uteri. However, the case presented is of an ectopic pregnancy in the rudimentary fallopian tube related to an undescended ovary in a patient with an isolated unicornuate uterus, a phenomenon which is extremely rare.
Discrepancy between clinical symptoms and Tc-99m MDP bone scan findings before and after strontium-89 therapy for metastatic bone pain of prostate carcinoma.
Authors: S S Sun, S C Tsai, J F Hsieh, J K Lee, C H Kao
Journal: Clinical Nuclear Medicine (2001)

SUN, SHUNG-SHUNG M.D.*; TSAI, SHIH-CHUAN M.D.†; HSIEH, JIH-FANG M.D.‡; LEE, JONG-KANG M.D.*; KAO, CHIA-HUNG M.D.§ Author Information
Phenomenology associated with depressed moods in adolescents
Authors: S C Inamdar, G Siomopoulos, M Osborn, E C Bianchi
Journal: American Journal of Psychiatry (1979)

The authors studied phenomenology associated with depressed moods in 30 adolescents within a semi-structured interview format using defined symptom items. The results suggest that while there is some symptomatic similarity between adolescent depression and depression in adults, there are many differences that warrant more cautious comparison and further study.
THE LACRYMAL GLAND IN SURGICAL ANAESTHESIA
Authors: L. T. Rutherford
Journal: BMJ (1913)

IMECDICAL JOURXNArl 3 ether and strychnine, she died about fifty minutes after the spinal injection.Permission to make a formal post-mortemi examination was refuse(d, hut the right kidney aind the heart were examined tljroug,h the operation wounid.There was no haemorrhage into the wound.The kidnev was hydro-nephrotic, containied clculi.and its cortex was tihin.Thie heart was fatty, and its mu*sculature very soft.IRcflecting, on this case it is difficult to say what
Levels of 3-Methylcholanthrene and 7,12-Dimethylbenz[&lt;italic&gt;a&lt;/italic&gt;]anthracene in Rat Mammary Fat Pads After Intragastric Administration, and Relationships to Carcinogenic Response&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;
Authors: R. Wieder, D. Thatcher, M. B. Shimkin
Journal: JNCI Journal of the National Cancer Institute (1967)

Levels of fluorescence-detectable 3-methylcholanthrene (MCA) and 7,12-dimethylbenzlalanthracene (DMBA) in mammary fat pads after gastric instillation of single and multiple dosages were determined in female and male Wistar and Sprague-Dawley rats. Peak levels for MCA were higher than those for DMBA. Levels in females were higher than in males and higher in inguinal tissue than in axillary tissue. Fluorescence-detectable DMBA disappeared from mammary fat pads more rapidly than MCA. Greatest uptake of MCA occurred with the use of digestible lipid vehicles. Repeated daily doses of MCA did not increase uptake levels beyond those of comparable single administrations. The data do not show any simple relationships between carcinogen levels as measured fluoro-metrically in mammary fat pads and carcinogenic response, but reveal several fruitful directions for further studies in pharmacodynamics and mechanism of action of carcinogens.
Therapy-related acute nonlymphocytic leukemia of FAB type M4 or M5 with early onset and t(9;11) (p21;q23) or a normal karyotype: a separate entity?
Authors: J Pedersen-Bjergaard, P Philip, V Ravn, S W Hansen, N I Nissen
Journal: Journal of Clinical Oncology (1988)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1988.6.2.395 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 3276828 Therapy-related acute nonlymphocytic leukemia of FAB type M4 or M5 with early onset and t(9;11) (p21;q23) or a normal karyotype: a separate entity? J Pedersen-BjergaardxJ Pedersen-BjergaardSearch for articles by this author , P PhilipxP PhilipSearch for articles by this author , V RavnxV RavnSearch for articles by this author , S W HansenxS W HansenSearch for articles by this author , N I NissenxN I NissenSearch for articles by this author https://doi.org/10.1200/JCO.1988.6.2.395 First Page PDF © 1988 by American Society of Clinical Oncology