tbuckley/cabot-search huggingface dataset:
Multicenter, randomized, phase II, double-blind trial of a combination of anthocyanins and curcumin for colon cancer prevention in subjects with colorectal adenoma. The MIRACOL study
Authors: M. Petrera, M. Puntoni, A. Parodi, G. Coccia, C. Crosta, N. Provinciali, A. De Censi
Journal: Annals of Oncology (2015)
The significance of past mania or hypomania in the course and outcome of major depression
Authors: W Coryell, N C Andreasen, J Endicott, M Keller
Journal: American Journal of Psychiatry (1987)

Patients with primary major depression (N = 372) were followed for 2 years to determine the prognostic importance of past manic or hypomanic episodes. While bipolar I and bipolar II patients were more likely to relapse and bipolar I patients were more likely to attempt suicide, these patients resembled nonbipolar depressed patients in likelihood of recovery and psychosocial impairment in various areas. Compared to nonbipolar patients, those with bipolar I depression were much more likely to develop mania, while bipolar II patients were more likely to develop hypomania. Cycling during the index episode predicted a relatively low likelihood of recovery for bipolar I patients but had no apparent prognostic significance for patients with bipolar II illness.
EUS-guided Celiac Plexus Neurolysis - Technique and Indication
Authors: N.  Schmulewitz, R.  Hawes
Journal: Endoscopy (2003)

Celiac plexus blockade (CPB) has been used in the management of pancreatic pain for the better part of a century. Until very recently, access to the celiac ganglia had been restricted to the surgeon, anesthesiologist and the radiologist. Advances in endoscopic ultrasound (EUS), and, most specifically, experience with fine-needle aspiration have allowed EUS-guided CPB to become a viable alternative to the more cumbersome techniques that preceded it. Although the precise role of CPB in patients with chronic upper abdominal pain stills needs to be defined, EUS promises to be a major factor in the future of this form of treatment.
REEVALUATION OF COMMON UTERINE OPERATIONS
Authors: S ABEL
Journal: JAMA (1952)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
An Evaluation of Some Genetic Factors Influencing Irradiation Protection by Bone Marrow
Authors: Delta E. Uphoff, L. W. Law
Journal: JNCI Journal of the National Cancer Institute (1959)

A study of the genetic factors influencing the grafting of bone marrow in lethally irradiated mice revealed that a single gene difference at the H-2 locus provided sufficient basis for the severe reaction of the secondary phase of the irradiation syndrome. The H-1 locus provided a variable reaction, while the H-3 locus produced no reaction. In the testing of 27 inbred-strain combinations, no combination was found in which good long-term survival was observed when the strains were of different H-2 phenotypes. Nine inbred-strain combinations in which the marrow donor and the recipient were of the same H-2 phenotype, either H-2b or H-2d, were found to be compatible. Hybrids of the genotype H-2d/H-2k were tested against strain A and gave further evidence that an immune response of the graft against the host was responsible for the secondary phase. A gene-dosage effect was proposed as a working hypothesis to explain the variability in response observed in F1 hybrids treated with parental-strain marrow in contrast to the response found among different inbred-strain combinations. Evidence for a threshold effect in antigen-antibody response of F1 hybrid mice treated with parental-strain marrow was discussed.
The Orphan Nuclear Receptor Nr4a1 Specifies Long-Term, Myeloid-Biased HSCs and Responds To PGE2
Authors: Anna Rayne, Ashley Vanderbeck, Trevor Barlowe, Sophie Eiger, Undergraduate, Shwetha Manjunath, Matthew Gross, Nicole Cunningham, Stephen G. Emerson, Jenni A. Punt
Journal: Blood (2013)
QOL-08PATIENT RELEVANT OUTCOMES IN RECURRENT GLIOBLASTOMA: A SYSTEMATIC LITERATURE REVIEW
Authors: James Signorovitch, Nanxin Li, Soomi Kim, Homa Dastani, James W. Shaw, Lucinda Orsini
Journal: Neuro-Oncology (2015)

BACKGROUND: This study was designed to systematically identify and summarize findings from studies reporting quality of life (QoL), neurocognitive function (NCF), or overall survival (OS) in patients with recurrent glioblastoma. METHODS: English-language articles published between 01/2005 and 10/2014 were identified using EMBASE, MEDLINE, and the Cochrane Library. Data were extracted by two reviewers, with discrepancies resolved by consensus. RESULTS: Fifty publications reporting clinical outcomes were identified. Median OS ranged from 3.4–24.5 months across all study arms. Eight studies reported QoL or NCF outcomes in patients with recurrent glioblastoma. Patient-reported outcome assessments included measures of general health-related QoL (SF-36), general cancer-related QoL (FACT-G, EORTC QLQ-C30) and brain cancer-specific QoL (FACT-BR, EORTC QLQ-BN20); NCF instruments assessed learning, memory, attention, visuomotor function, mental flexibility, executive function, and lexical fluency (eg, Hopkins Verbal Learning Test-Revised, Trail-Making Test, Controlled Oral Word Association Test). Most studies included instruments validated for use in patients with brain cancer but not specifically tailored for glioblastoma. Baseline QoL and NCF among patients with recurrent glioblastoma were generally worse compared to both the general population and patients with other cancers. Treatments either had no impact on QoL or led to worse QoL. QoL was maintained after radiotherapy and alternating electric field therapy; targeted therapies, (ie, sunitinib, temozolomide, and lomustine) were associated with worse QoL, potentially due to treatment-related toxicities. No studies reported treatment benefits for NCF, however better tumor responses were associated with improved or stable NCF during treatment with bevacizumab +/- chemotherapy. Better measures of emotional and functional well-being were correlated with lower risks of progression and death, respectively. CONCLUSIONS: QoL and NCF are severely impaired in recurrent glioblastoma, reflecting aggressive disease progression and poor survival associated with this tumor. Novel treatment approaches are needed to improve survival and overall functioning.
Interest of the CD148, CD180 and CD200 Combination in Flow Cytometry Analyses for Mature B-Cell Neoplasms Diagnosis
Authors: Laurent Miguet, Caroline Mayeur-Rousse, Sarah Lennon, Luc Fornecker, Carine Gervais, Antoine Ittel, Anne-Cécile Galoisy, Alice Eischen, Jean-francois Lesseve, Veronique Latger-Cannard, Raoul Herbrecht, Sarah Cianferani, Laurent Mauvieux
Journal: Blood (2014)
Schizophrenic thought disorders: bizarre associations and intermingling
Authors: M Harrow, M Prosen
Journal: American Journal of Psychiatry (1979)

The authors assessed bizarre verbalizations elicited from 37 schizophrenic and 16 nonschizophrenic patients. Interviews with subjects indicated that much bizarre schizophrenic language results from patients intermingling material from past and current experiences into their verbalizations. This intermingled material comes from many different problem areas rather than one central emotional complex. It does not arise from emotional overresponsiveness, overinvolved thinking, or delusional ideation. Two factors hypothesized as responsible for bizarre schizophrenic language are the schizophrenic's monitoring problems and difficulty maintaining perspective about his own behavior.
808 nm Light-triggered and hyaluronic acid-targeted dual-photosensitizers nanoplatform by fully utilizing Nd3+-sensitized upconversion emission with enhanced anti-tumor efficacy
Authors: Zhiyao Hou, Kerong Deng, Chunxia Li, Xiaoran Deng, Hongzhou Lian, Ziyong Cheng, Dayong Jin, Jun Lin
Journal: Biomaterials (2016)
Dendritic Polymers for Theranostics
Authors: Yuan Ma, Quanbing Mou, Dali Wang, Xinyuan Zhu, Deyue Yan
Journal: Theranostics (2016)

Dendritic polymers are highly branched polymers with controllable structures, which possess a large population of terminal functional groups, low solution or melt viscosity, and good solubility. Their size, degree of branching and functionality can be adjusted and controlled through the synthetic procedures. These tunable structures correspond to application-related properties, such as biodegradability, biocompatibility, stimuli-responsiveness and self-assembly ability, which are the key points for theranostic applications, including chemotherapeutic theranostics, biotherapeutic theranostics, phototherapeutic theranostics, radiotherapeutic theranostics and combined therapeutic theranostics. Up to now, significant progress has been made for the dendritic polymers in solving some of the fundamental and technical questions toward their theranostic applications. In this review, we briefly summarize how to control the structures of dendritic polymers, the theranostics-related properties derived from their structures and their theranostics-related applications.
Abstract A46: Cellular apoptosis susceptibility (CAS) regulates integrin-beta1 and is required for tumor cell migration and invasion in hepatocellular carcinoma (HCC)
Authors: Juliane Winkler, Carsten Sticht, Amanda DiGuilio, Eva Maria Eiteneuer, Kerstin Holzer, Stephanie Rössler, Norbert Gretz, Kai Breuhahn, Peter Schirmacher, Alessandro Ori, Stephan Singer
Journal: Cancer Research (2016)

Abstract Nuclear transport is an essential, highly selective process in eukaryotic cells which guarantees the bidirectional communication between the nucleus and the cytoplasm. Emerging evidence suggests that aberrant expression of nuclear transport factors may contribute to cancer formation and progression. We could recently show that the nuclear exporter Cellular apoptosis susceptibility (CAS) is overexpressed in hepatocellular carcinoma (HCC), the functional implications of which remain, however, not completely understood. Here, we integrated proteomics, transcriptomics and functional assays with patient data to further characterize the role of CAS in HCC. We found that CAS depletion in HCC cells led to deregulation of integrins, particularly integrin-beta1, and resulted in reduced cell migration and invasion. Moreover, we determined that high expression levels of CAS in HCC cases were associated with macroangioinvasion and poorer patient outcome. Our data indicate that CAS is linked to integrin signaling and correlates with an aggressive HCC phenotype. Citation Format: Juliane Winkler, Carsten Sticht, Amanda DiGuilio, Eva Maria Eiteneuer, Kerstin Holzer, Stephanie Rössler, Norbert Gretz, Kai Breuhahn, Peter Schirmacher, Alessandro Ori, Stephan Singer. Cellular apoptosis susceptibility (CAS) regulates integrin-beta1 and is required for tumor cell migration and invasion in hepatocellular carcinoma (HCC). [abstract]. In: Proceedings of the Fourth AACR International Conference on Frontiers in Basic Cancer Research; 2015 Oct 23-26; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2016;76(3 Suppl):Abstract nr A46.
Abstract B12: GABP selectively binds and activates the mutant TERT promoter across multiple cancer types
Authors: Robert J.A Bell, H. Tomas Rube, Alex Kreig, Andrew Mancini, Shaun F. Fouse, Raman P. Nagarajan, Serah Choi, Chibo Hong, Daniel He, Melike Pekmezci, John K. Wiencke, Margaret R. Wrensch, Susan M. Chang, Kyle M. Walsh, Sua Myong, Jun S. Song, Joseph F. Costello
Journal: Cancer Research (2015)

Abstract Reactivation of telomerase reverse transcriptase (TERT) expression enables cells to overcome replicative senescence and escape apoptosis, fundamental steps in the initiation of human cancer. Multiple cancer types, including up to 83% of glioblastomas (GBM), harbor highly recurrent mutations in the TERT promoter specific to two nucleotide positions. The common mutation sites, G228A and G250A, may create de-novo ETS family transcription factor binding sites, but the precise mechanism of how these mutations confer increased TERT expression has been elusive. Here, we demonstrate the de-novo ETS motif to be critical for mutant TERT activation by site directed mutagenesis. A focused siRNA screen of the many ETS transcription factors expressed in GBM identifies GABPA as the single ETS factor to selectively regulate the mutant but not the wild type TERT promoter. Single molecule binding assays and ChIP-qPCR analysis reveal that GABPA is exclusively recruited to the mutant allele in vitro and in vivo respectively. Furthermore, this allelic recruitment is consistent across four tested cancer types, highlighting a shared mechanism underlying mutant TERT promoter activation. Tandem flanking native ETS motifs critically cooperate with these mutations to activate TERT, likely by facilitating GABP heterotetramer binding. GABP thus directly links TERT promoter mutations to aberrant expression and may provide a novel therapeutic target for multiple cancers. Citation Format: Robert J.A Bell, H. Tomas Rube, Alex Kreig, Andrew Mancini, Shaun F. Fouse, Raman P. Nagarajan, Serah Choi, Chibo Hong, Daniel He, Melike Pekmezci, John K. Wiencke, Margaret R. Wrensch, Susan M. Chang, Kyle M. Walsh, Sua Myong, Jun S. Song, Joseph F. Costello. GABP selectively binds and activates the mutant TERT promoter across multiple cancer types. [abstract]. In: Proceedings of the AACR Special Conference: Advances in Brain Cancer Research; May 27-30, 2015; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2015;75(23 Suppl):Abstract nr B12.
Mutagenicity for Salmonella typhimurium of Urine Obtained From Humans Receiving Nitrofurantoin2
Authors: Ching Yung Wang, Ralph C. Benson, George T. Bryan
Journal: JNCI Journal of the National Cancer Institute (1977)

Urine samples from 12 humans receiving oral therapeutic doses of nitrofurantoin were mutagenic for Salmonella typhimurium strain TA 100 and non mutagenic for strain TA 100-FR1. Mutagenic activity of the urine was not increased by treatment with β-glucuronidase. Spot mutation assay of the chromatogram of urine revealed that the mutagenic activity of the urine was mainly due to unmetabolized nitrofurantoin.
Current perspectives on childhood depression: an overview
Authors: J H Kashani, A Husain, W O Shekim, K K Hodges, L Cytryn, D H McKnew
Journal: American Journal of Psychiatry (1981)

The rapidly increasing research interest in childhood depression indicates that it has become a recognized disorder. The authors review the literature on depression in children, focusing on epidemiology, various diagnostic criteria, classification schemes, assessment instruments, and intervention studies that have been applied to childhood depression. Given that there are many etiological factors, it will be important to study the disorder from various conceptual frameworks, including biochemical, genetic learned helplessness, life stresses, cognitive distortion, behavioral reinforcement, and sociological models.
Single-molecule detection and tracking of RNA transcripts in living cells using phosphorothioate-optimized 2′-O-methyl RNA molecular beacons
Authors: Dan Zhao, Yantao Yang, Na Qu, Mingming Chen, Zhao Ma, Christopher J. Krueger, Mark A. Behlke, Antony K. Chen
Journal: Biomaterials (2016)

Molecular Beacons (MBs) composed of 2′-O-methyl RNA (2Me) and phosphorothioate (PS) linkages throughout the backbone (2Me/PSFULL MBs) have enabled long-term imaging of RNA in living cells, but excess PS modification can induce nonspecific binding, causing false-positive signals. In this study, we evaluate the intracellular stability of MBs composed of 2Me with various PS modifications, and found that false-positive signals could be reduced to marginal levels when the MBs possess a fully PS-modified loop domain and a phosphodiester stem (2Me/PSLOOP MB). Additionally, 2Me/PSLOOP MBs exhibited uncompromised hybridization kinetics, prolonged functionality and >88% detection accuracy for single RNA transcripts, and could do so without interfering with gene expression or cell growth. Finally, 2Me/PSLOOP MBs could image the dynamics of single mRNA transcripts in the nucleus and the cytoplasm simultaneously, regardless of whether the MBs targeted the 5'- or the 3′-UTR. Together, these findings demonstrate the effectiveness of loop-domain PS modification in reducing nonspecific signals and the potential for sensitive and accurate imaging of individual RNAs at the single-molecule level. With the growing interest in the role of RNA localization and dynamics in health and disease, 2Me/PSLOOP MBs could enable new discoveries in RNA research.
Comment on American Diabetes Association. Approaches to Glycemic Treatment. Sec. 7. In <i>Standards of Medical Care in Diabetes—2016</i>. Diabetes Care 2016;39(Suppl. 1):S52–S59
Authors: Dario Giugliano, Maria Ida Maiorino, Giuseppe Bellastella, Katherine Esposito
Journal: Diabetes Care (2016)

The Standards of Medical Care in Diabetes—2016 (1) released by the American Diabetes Association in the classic January issue supplement made no relevant change for insulin therapy in type 2 diabetes—an issue that probably concerns about 6 million U.S. adults using diabetes medication (2). Although we agree that the basal insulin regimen is a convenient way to start insulin therapy when needed for most patients, we have some concerns about advancing to combination injectable therapy to cover postprandial glucose excursions.

At the level of two injections per day, three options are offered after basal insulin failure: adding a glucagon-like peptide 1 (GLP-1) receptor agonist (GLP-1-RA), adding a mealtime insulin injection, or transitioning to …
Abstract P5-05-03: Targeting hypoxia-induced cancer cell metabolism in breast cancer
Authors: DA Cavazos, A Gruslova, M Garcia, AJ Brenner
Journal: Cancer Research (2016)

Abstract Rational: Hypoxia contributes to high tumor grade in human breast cancer and is associated with resistance to radiation and chemotherapy. Hypoxia is generally encountered in perinecrotic regions throughout the heterogeneous tumor microenvironment and may be due to rapid tumor grow, insufficient neovascularization or as a result of antiangiogenic and chemoradiation therapies which cause acute vascular thrombosis. Cancer stem-like cells residing within these hypoxic zones compensate for the low concentration of oxygen through alterations in metabolism that favor aerobic glycolysis and de novo fatty acid synthesis. These metabolic derangements are known to enhance proliferation and survival, although the contributing molecular mechanisms are not fully understood. Here we evaluate a panel of FDA approved azole drugs for alternative use as glycolytic inhibitors with and without the fatty acid synthase (FASN) inhibitor, TBV-3166. TVB-3166 is currently in phase II clinical trials and is the first FASNi approved for human testing. METHODS: IC50 values of single or combined agents were determined by MTT under conditions of normoxia and hypoxia using sister plates of estrogen receptor positive or triple negative breast cancer cells, MCF-7, SKBR3 and MDA-MB-231. RESULTS: Because the combination of Itraconazole and TVB-3166 displayed a synergistic enhancement in cell death at a low nanomolar concentrations in MCF-7 cells, we next assessed the efficacy of these drugs in an in vivo xenograft model of breast cancer. Here, 3.6 million MCF-7 cells were implanted into the right flanks of (n=16) athymic nude mice, which were then randomized by tumor volume into 4 groups. Itraconazole and TVB-3166 were administered at 60 mg/kg daily by oral gavage as single agents or combined throughout the duration of the study. After three weeks, mice treated with combined inhibitors exhibited best response with a statistically significant decrease in tumor volume compared to the vehicle control group. CONCLUSION: Given the significant tumor response to the combination of metabolic inhibitors, further studies that evaluate the radiosensitizing effects under conditions of hypoxia are warranted. By targeting hypoxia-induced metabolic pathways during radiotherapy, we may enhance cancer stem-like cell death to dramatically improve patient outcome. Citation Format: Cavazos DA, Gruslova A, Garcia M, Brenner AJ. Targeting hypoxia-induced cancer cell metabolism in breast cancer. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr P5-05-03.
HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR EXTRANODAL NK/T-CELL LYMPHOMA, NASAL-TYPE: THE JAPAN SOCIETY FOR HEMATOPOIETIC CELL TRANSPLANTATION (JSHCT) LYMPHOMA WORKING PARTY
Authors: Suzumiya J, Sakamaki H, Endo T, Shinagawa K, Ito T, Izutsu K, Hyo R, Kako S, Suzuki R
Journal: Annals of Oncology (2011)
Urological Surgeons in Conference
Authors: J M R THOMAS
Journal: BMJ (1948)

The British Association of Urological Surgeons held a meeting in London, under the presidency of Mr. Clifford-Morson, from June 24 to 26.The principal subjects of discussion were the surgery of urethral stricture and the aetiology and treatment of renal and ureteral calculi ; but many miscellaneous papers were read and films shown, and operating sessions and demonstrations were arranged at ten London hospitals. Surgery of Urethral StrictureThe visitors were the guests of the Section of Urology of the Royal Society of Medicine for a discussion on the surgery of urethral stricture.It was opened by Mr. H.L. Attwater, who referred to the slow onset of such strictures.The initial causes