tbuckley/cabot-search huggingface dataset:
The Age Factor in the Treatment of Glioblastoma
Authors: Stephen W. Clark
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis
Authors: An Tran-Duy, Bart Spaetgens, Arno W. Hoes, Niek J. de Wit, Coen D.A. Stehouwer
Journal: Clinical Gastroenterology and Hepatology (2016)
Multiple apocrine hidrocystomas successfully treated with botulinum toxin A
Authors: J.R. Bordelon, N. Tang, D. Elston, G. Niedt, T. Lazic Strugar
Journal: British Journal of Dermatology (2016)

Apocrine hidrocystomas, while rare, present predominantly as solitary papules occurring in the periocular region of the face. Various treatment modalities for these lesions exist depending on their size and location, but the management of multiple hidrocystomas can be more challenging. Recent reports illustrate that multiple eccrine hidrocystomas have been successfully treated with botulinum toxin A. Herein we describe the effective use of botulinum toxin A in a 29‐year‐old man with multiple facial apocrine hidrocystomas, which, to our knowledge, has not yet been reported in the English‐language literature.
Prognostic assessment in node-negative breast cancer patients.
Authors: R Holland, A L Verbeek
Journal: Journal of Clinical Oncology (1990)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1990.8.9.1451 Journal of Clinical Oncology - published online before print September 22, 2016 PMID: 2391555 Prognostic assessment in node-negative breast cancer patients. R HollandxR HollandSearch for articles by this author , A L VerbeekxA L VerbeekSearch for articles by this author Show More University of Nijmegen, The Netherlands. https://doi.org/10.1200/JCO.1990.8.9.1451 First Page PDF © 1990 by American Society of Clinical Oncology
Abstract PR06: Metastatic latency and immune evasion mediated by autocrine WNT inhibition
Authors: Srinivas Malladi, Danilo G. Macalinao, Xin Jin, Lan He, Joan Massague
Journal: Cancer Research (2016)

Abstract Metastasis frequently develops years after the removal of a primary tumor, from a minority of disseminated cancer cells that survived as latent entities through unknown mechanisms. We isolated latency competent cancer (LCC) cells from early-stage human lung and breast carcinomas and defined the mechanisms that prevent the outgrowth, support the long-term survival, and maintain the tumor-initiating potential of these cells during the latent metastasis stage. LCC cells show stem cell-like characteristics and express Sox transcription factors, which are essential for their survival in host organs under restrictive conditions and for metastatic outgrowth under permissive conditions. Through WNT inhibition, LCC cells self-impose a slow cycling state and evade immune clearance. By expressing a Sox-dependent stem-like state and actively silencing WNT signaling, LCC cells can enter quiescence and evade innate immunity to remain latent for extended periods. Citation Format: Srinivas Malladi, Danilo G. Macalinao, Xin Jin, Lan He, Joan Massague. Metastatic latency and immune evasion mediated by autocrine WNT inhibition. [abstract]. In: Proceedings of the AACR Special Conference on Tumor Metastasis; 2015 Nov 30-Dec 3; Austin, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(7 Suppl):Abstract nr PR06.
Case 48-1979
Authors: Richard C. Cabot, Robert E. Scully, James J. Galdabini, Betty U. McNeely, Carl A. Olsson, William R. Welch
Journal: New England Journal of Medicine (1979)

Presentation of CaseA 40-year-old woman, para 3, gravida 3, was admitted to the hospital because of left ureteral obstruction.She was well until six years earlier, when a urinary-tract infection developed. An intravenous pyelographic examination in Portugal was reported to be negative. She experienced dyspareunia, and repeated urinary-tract infections occurred during the next few years. Four years before admission another intravenous pyelographic examination was reported to show an abnormality of the left ureter. Twenty-six months before entry, shortly after immigration to this country, she was first seen at this hospital, where examination revealed that the blood pressure was 180/120 . . .
Oxygen Toxicity in Man
Authors: Richard E. Barber, Joseph Lee, William K. Hamilton
Journal: New England Journal of Medicine (1970)

To investigate possible pulmonary oxygen toxicity in man, 10 patients who had suffered irreversible brain damage received ventilation with air (five patients) or pure oxygen (five patients) until death. Measurements of arterial-blood gases, cardiac output, intrapulmonary shunt, ratio of dead space to tidal volume and lung-thorax compliance were made periodically. At autopsy, gross condition and total weight of the lungs were noted. The oxygen group demonstrated significantly greater impairment of lung function than the air group. The most sensitive indicator of impaired lung function was a decrease in arterial oxygen tension during breathing of pure oxygen. After 30 hours' ventilation this value declined more sharply in the oxygen group than the air group. After 50 hours it averaged above 400 torr in the air group but only 120 torr in the oxygen group. Intrapulmonary shunt and ratio of dead space to tidal volume also became significantly greater in the oxygen group. Radiographic changes and total lung weight supported these physiologic findings. Microscopical examination of lung tissue failed to reveal noteworthy differences between the two groups.
Correlation of Anxiety and Hostility With Adrenocortical Function
Authors: Theodore Wohl, Leon J. Sholiton, Emile E. Werk
Journal: JAMA (1963)

DURING THE COURSE of their disease, patients with bronchogenic carcinoma manifest adrenocortical hyperfunction as measured by several parameters. One of the most notable indices of this hyperactivity appears to be the concentration of morning plasma unconjugated 17-hydroxycorticosteroids (17-OHCS) which increase as the disease progresses and the interval to death shortens. Although several metabolic aspects might be suspected of influencing the adrenocortical status of these seriously ill patients, a possible factor to be considered is their emotional state, as numerous studies of patients with cancer have indicated a wide range of emotional response. Of the many emotional factors to be considered, anxiety has been most closely associated with changes in adrenocortical function,<sup>1, 2</sup>probably through neuroendocrine pathways affecting corticotrophin release. The purpose of the present study has been to explore this possible relationship by correlating plasma 17-OHCS levels with anxiety in patients with and without lung cancer. The factor
Systemic AAV9-IFNβ gene delivery treats highly invasive glioblastoma
Authors: Dwijit GuhaSarkar, Qin Su, Guangping Gao, Miguel Sena-Esteves
Journal: Neuro-Oncology (2016)

Complete surgical removal of all glioblastoma (GBM) cells is impossible due to extensive infiltration into brain parenchyma that ultimately leads to tumor recurrence. The current standard of care affords modest improvements in survival. New therapeutic interventions are needed to prevent recurrence. Local AAV-hIFNβ gene delivery to the brain was previously shown to eradicate noninvasive orthotopic U87 tumors in mice. However, widespread CNS gene delivery may be necessary to treat invasive GBMs. Here we investigated the therapeutic effectiveness of systemically infused AAV9-hIFNβ against an invasive orthotopic GBM8 model. Mice bearing human GBM8 brain tumors expressing firefly luciferase (Fluc) were treated systemically with different doses of scAAV9-hIFNβ vector. Therapeutic efficacy was assessed by sequential bioluminescence imaging of tumor Fluc activity and animal survival. Brains were analyzed post mortem for the presence and appearance of tumors. Two transcriptionally restricted AAV vectors were used to assess the therapeutic contribution of peripheral hIFNβ. Systemic infusion of scAAV9-hIFNβ vector induced complete regression of established GBM8 tumors in a dose-dependent manner. The efficacy of this approach was also dependent on the stage of tumor growth at the time of treatment. We also showed that peripherally produced hIFNβ contributed considerably to the therapeutic effect of scAAV9-hIFNβ. A comparative study of systemic and unilateral intracranial delivery of scAAV9-hIFNβ in a bilateral GBM8 tumor model showed the systemic route to be the most effective approach for treating widely dispersed tumors. Systemic delivery of AAV9-IFNβ is an attractive approach for invasive and multifocal GBM treatment.
Abstract 5469: PPAR{delta} Agonist Decreases Inflammatory Burden of Abdominal Fat by Reducing Adipose Macrophage Levels and Chemotaxis in Humans
Authors: Lea Sarov-Blat, Barbara Kozac, Lisa Cass, Gengqian Cai, Jeffrey Gimble, Dennis Sprecher, Steven Smith
Journal: Circulation (2008)
Abstract B60: Identification of an ovarian tumor:stromal HH:BMP4 signaling loop critical to ovarian cancer growth and chemotherapy resistance.
Authors: Lan G. Coffman, Yunjung Choi, Karen Mclean, Marina Pasca di Magliano, Benjamin Allen, Ronald J. Buckanovich
Journal: Clinical Cancer Research (2016)

Abstract The ovarian tumor microenvironment is critical to ovarian cancer growth, spread, and survival. We recently identified a novel host cell component of the tumor microenvironment, human ovarian carcinoma-associated mesenchymal stem cells (CA-MSCs). CA-MSCs are of particular interest as they are multi-potent and can differentiate to create many components of the tumor microenvironment including fibroblasts, myofibroblasts and adipocytes. CA-MSCs, compared to normal MSCs, express high levels of BMP proteins and promote tumor growth by increasing numbers of cancer stem-like cells (CSCs). We now define a CA-MSC BMP4: ovarian tumor cell Hedgehog (HH) positive feedback loop critical to the cancer promoting functions of CA-MSCs. We demonstrate that CA-MSC expression of BMP4 is induced by ovarian tumor cell-secreted Hedgehog (HH). Reciprocally, CA-MSC-derived BMP4 increases ovarian tumor cell HH expression creating a positive feedback loop. Interruption of this loop with either a HH pathway inhibitor (IPI-926 or LDE-225) or BMP4 blocking antibody decreases the induction of CA-MSC-derived BMP4 and tumor-derived HH. This signaling loop is critical to the pro-tumorigenic effects of CA-MSCs as HH inhibition blocked CA-MSC-mediated tumorigenesis and reduced the number of CSCs. Additionally, HH inhibition reversed CA-MSC -induced chemotherapy resistance leading to significant cisplatin response in established platinum-resistant tumors. Collectively, we define a critical positive feedback loop between CA-MSC-derived BMP4 and ovarian tumor cell-secreted HH providing further support for clinical targeting of the HH pathway, particularly in combination with platinum-based chemotherapy, in ovarian cancer. Citation Format: Lan G. Coffman, Yunjung Choi, Karen Mclean, Marina Pasca di Magliano, Benjamin Allen, Ronald J. Buckanovich. Identification of an ovarian tumor:stromal HH:BMP4 signaling loop critical to ovarian cancer growth and chemotherapy resistance. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Ovarian Cancer Research: Exploiting Vulnerabilities; Oct 17-20, 2015; Orlando, FL. Philadelphia (PA): AACR; Clin Cancer Res 2016;22(2 Suppl):Abstract nr B60.
Adverse Drug Interactions
Authors: S K Bhattacharya
Journal: JAMA (1972)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
High Transcription Levels Of S100A8 and S100A9 In Acute Myeloid Leukemia Are Predictors For Poor Overall Survival
Authors: Shao-yan Hu, Ming-ying Zhang, Shui-yan Wu, Dong Wu, Neetika Ashwani, Jian Pan, Hai-long He, Jian-nong Cen, Zi-Xing Chen, Chien-Shing Chen
Journal: Blood (2013)
Joint admission as a treatment modality for problem drinkers: a case report
Authors: T J Paolino, B S McCrady
Journal: American Journal of Psychiatry (1976)

Joint hospital admission of a married alcoholic and his/her spouse can facilitate treatment of the problem drinker. A case report illustrates the advantages of this approach in giving the staff an opportunity to observe and provide the couple with feedback about their patterns of interaction and to provide specific therapeutic interventions during the joint admission.
Prostate Lymphoma Complicated With Prostatorectal Fistula and Multifocal Infection After Chemotherapy
Authors: Pan-Fu Kao, Juey-Hong Weng, Pei-Ching Hsiao, Yu-Lin Kao
Journal: Clinical Nuclear Medicine (2015)

A 67-year-old man with a biopsy proving prostate diffuse large B-cell lymphoma was referred for an 18F-FDG PET/CT scan for postchemotherapy treatment monitoring. The FDG PET/CT scan revealed a significant reduction of prostate lymphoma and a prostatorectal fistula formation. The patient developed Klebsiella pneumoniae sepsis, and a follow-up FDG PET/CT 3 months later revealed multifocal lung, bone, and muscle infection. The FDG PET/CT scans of this patient not only demonstrated the effectiveness of chemotherapy for prostate lymphoma but also the complications of a prostatorectal fistula and multiple infectious foci.
Is Emphysema a Disease Predominantly of the White Male?
Authors: Richard E. Murphy
Journal: JAMA (1962)

THE INCIDENCE of emphysema is increasing, and with it has come a steady expansion of literature on the subject. To be sure, the increase may be relative, through better diagnosis, or it may be real, due to conditions both known and unknown. There are now more elderly people; industrialization has advanced; smog is on the increase; and smoking (local smog) has reached an all-time high. These factors are, no doubt, contributing to the alarming rise in emphysema. One facet in the etiology of emphysema has not received adequate recognition—the racial incidence. Impressed by the observation that diffuse obstructive emphysema was relatively uncommon in the Negro, we decided to test its validity. Method Included in this evaluation were only those patients with generalized, diffuse, obstructive emphysema. Excluded were patients with emphysema secondary to known underlying pulmonary disorders such as tuberculosis, pneumonoconiosis, bronchiectasis, and sarcoidosis. The patient material considered was gathered from
P0711 : Genome-wide association study of response to sofosbuvir-ribavirin treatment in GT2/3 HCV patients
Authors: S.E. Kleinstein, T.J. Urban, N. Long, A. Thompson, E.J. Gane, S. Zeuzem, Z. Jiang, D. Ge, M.S. Paulson, R.H. Hyland, D.M. Brainard, A. Gaggar, G. Mani Subramanian, J.G. McHutchison, A. Muir, M. Sulkowski, E. Lawitz, D.B. Goldstein
Journal: Journal of Hepatology (2015)
Incidental Diagnosis of Prostate Cancer by F-18 FDG PET/CT
Authors: Antoine Monet, Bertrand Merino, Régine Lupo
Journal: Clinical Nuclear Medicine (2009)

A 67-year-old man underwent whole-body F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) for lymphoma screening. The results demonstrated no evidence of lymphoma recurrence, but a focal increased uptake of F-18 FDG in the prostate. There was no history of urinary symptoms. A biopsy diagnosed a prostatic adenocarcinoma. Incidentally, focal intense FDG uptake in the prostate gland should always require further investigations to confirm the presence of prostate cancer.
Marine ω-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells
Authors: Mingyang Song, Reiko Nishihara, Yin Cao, Eunyoung Chun, Zhi Rong Qian, Kosuke Mima, Kentaro Inamura, Yohei Masugi, Jonathan A. Nowak, Katsuhiko Nosho, Kana Wu, Molin Wang, Edward Giovannucci, Wendy S. Garrett, Charles S. Fuchs, Shuji Ogino, Andrew T. Chan
Journal: JAMA Oncology (2016)

<h3>Importance</h3> Marine ω-3 polyunsaturated fatty acids (PUFAs), including eicosapentaenoic acid, docosahexaenoic acid, and docosapentaenoic acid, possess potent immunomodulatory activity and may protect against cancer development. However, evidence relating marine ω-3 PUFAs to colorectal cancer (CRC) risk remains inconclusive. <h3>Objective</h3> To test the hypothesis that marine ω-3 PUFA intake may be associated with lower risk of CRC subsets characterized by immune infiltrate. <h3>Design, Setting, and Participants</h3> This prospective cohort study was conducted among participants in the Nurses' Health Study (1984-2010) and Health Professionals Follow-up Study (1986-2010). <h3>Exposures</h3> Intake of marine ω-3 PUFAs. <h3>Main Outcomes and Measures</h3> Incidence of CRC characterized by CD3<sup>+</sup>, CD8<sup>+</sup>, CD45RO (PTPRC)<sup>+</sup>, or FOXP3<sup>+</sup>T-cell densities in tumor tissue, measured by immunohistochemical and computer-assisted image analysis. <h3>Results</h3> Among 173 229 predominantly white participants, 125 172 with 2 895 704 person-years of follow-up provided data about marine ω-3 PUFA intake every 4 years through a validated food frequency questionnaire and followed up for incident CRC evaluation. Of 2504 CRC cases, we documented 614 (252 men, 362 women) from which we could assess T-cell infiltration in the tumor microenvironment. The inverse association of marine ω-3 PUFAs intake with CRC risk differed according to FOXP3<sup>+</sup>T-cell infiltration: compared with intake of less than 0.15 g/d of marine ω-3 PUFAs, intake of at least 0.35 g/d was associated with a multivariable hazard ratio (HR) of 0.57 (95% CI, 0.40-0.81;<i>P</i> &lt; .001 for trend) for FOXP3<sup>+</sup>T-cell-high tumors. In contrast, the HR for FOXP3<sup>+</sup>T-cell-low tumors was 1.14 (95% CI, 0.8-1.60) (<i>P</i> = .77 for trend;<i>P</i> = .01 for heterogeneity). No statistically significant differential association was found for high-density tumors (compared with low-density tumors) according to CD3<sup>+</sup>, CD8<sup>+</sup>, or CD45RO<sup>+</sup>cell density (<i>P</i> ≥ .34 for heterogeneity for all comparisons). In functional assays, the suppressive activity of regulatory T cells was approximately 2-fold lower (T-effector-cell proliferation, ≥64% vs 38%) when preincubated with docosahexaenoic acid at 50μM, 100μM, and 200μM concentrations than without docosahexaenoic acid (<i>P</i> &lt; .001 for all comparisons). <h3>Conclusions and Relevance</h3> High marine ω-3 PUFA intake was associated with lower risk of CRC with high-level, but not low-level, FOXP3<sup>+</sup>T-cell density, suggesting a potential role of ω-3 PUFAs in cancer immunoprevention through modulation of regulatory T cells.
Current status of calcium channel-blocking drugs after Q wave and non-Q wave myocardial infarction.
Authors: Gibson Rs
Journal: Circulation (1989)

The calcium channel blockers are useful in treating many cardiovascular disorders. Due to their anti-ischemic and spasmolytic properties, the cardioprotective effects of these agents have been studied in the setting of acute myocardial infarction. This paper will review this application with respect to limitation of infarct size, reduction of mortality, and incident morbidity rates. Of the agents currently available for clinical use, nifedipine has been studied most extensively. This agent shows no beneficial effects and its use can, in fact, be harmful in this setting. Of the few trials that have been conducted with verapamil, none have shown a preventive effect on death, reinfarction, or postinfarction angina. Both verapamil and diltiazem might limit infarct size although further confirmation is required. At the present time, diltiazem is the only agent shown to have short- and long-term benefits on clinical outcome in patients with acute myocardial infarction. The success of prophylactic diltiazem is, however, critically dependent on proper patient selection. In particular, those patients with non-Q wave infarction, normal left ventricular function, or both can be expected to derive the greatest benefit in terms of reduced mortality and incident morbidity.
Lyme borreliosis in Europe
Authors: A Rizzoli, H C Hauffe, G Carpi, G I Vourc’h, M Neteler, R Rosà
Journal: Eurosurveillance (2011)

Despite improvements in prevention, diagnosis and treatment, Lyme borreliosis (LB) is still the most common arthropod-borne disease in temperate regions of the northern hemisphere, with risk of infection associated with occupation (e.g. forestry work) and certain outdoor recreational activities (e.g. mushroom collecting). In Europe, LB is caused by infection with one or more pathogenic European genospecies of the spirochaete Borrelia burgdorferi sensu lato, mainly transmitted by the tick Ixodes ricinus. Recent surveys show that the overall prevalence of LB may be stabilising, but its geographical distribution is increasing. In addition, much remains to be discovered about the factors affecting genospecific prevalence, transmission and virulence, although avoidance of tick bite still appears to be the most efficient preventive measure. Uniform, European-wide surveillance programmes (particularly on a local scale) and standardisation of diagnostic tests and treatments are still urgently needed, especially in the light of climate change scenarios and land-use and socio-economic changes. Improved epidemiological knowledge will also aid development of more accurate risk prediction models for LB. Studies on the effects of biodiversity loss and ecosystem changes on LB emergence may identify new paradigms for the prevention and control of LB and other tick-borne diseases.