tbuckley/cabot-search huggingface dataset:
Iodine-123 BMIPP and Ga-67 Scintigraphy in Liposarcoma
Authors: Y Yamamoto, Y Nishiyama, Y Ono, K Fukunaga, K Satoh, M Ohkawa, I Hamamoto, M Tanabe
Journal: Clinical Nuclear Medicine (1998)

A patient with recurrent retroperitoneal liposarcoma had multiple suspected metastases. I-123 BMIPP imaging showed areas of increased uptake due to accumulation in the myxoid components of the liposarcoma. Ga-67 showed accumulation in the undifferentiated components. The well-differentiated components showed little accumulation of either I-123 BMIPP or Ga-67. Differences in the accumulation of these radionuclides may reflect differences in cell densities, fatty acid metabolism, and the degree of malignancy. I-123 BMIPP and Ga-67 scintigraphy may be useful in determining the prognosis of liposarcoma.
OC-072 Use Of A Novel Self-expanding Metal Stent To Allow For Endoscopic Drainage And Necrosectomy Of Pancreatic Fluid Collections
Authors: MT Huggett, KW Oppong, SP Pereira, V Mitra, RM Charnley, MK Nayar
Journal: Gut (2014)

<h3>Introduction</h3> Post-inflammatory peri-pancreatic fluid collections are frequent sequelae of severe acute pancreatitis. Collections are at risk of suppurative infection complicated by pancreatic necrosis. Over the last decade there has been an increasing emphasis on minimally invasive drainage procedures, including EUS-guided cyst-gastrostomy, and these approaches seem to be associated with lower morbidity and mortality. Access to the necrosis cavity has however been severely limited by having to maintain the tract with small diameter plastic stents. Recently, a novel flanged fully covered self-expanding metal stent (FCSEMS; NAGI stent, Taewoong Medical, Korea) has been developed to allow for better drainage of infected necrosis and easier endoscopic access into the cavity. <h3>Setting</h3> A non-randomised prospective multicentre phase II study to determine the safety and efficacy of FCSEMS endoscopic cyst-gastrostomy in the management of complex/infected pancreatic fluid collections. <h3>Methods</h3> Patients were included if they had evidence of a pancreatic fluid collection which was deemed to be amenable for EUS-guided drainage after discussion at a HPB multidisciplinary meeting. Patients selected for EUS-guided drainage had cross sectional imaging (MR or CT) performed within 2 weeks of the procedure and then an EUS assessment was made of the necrotic component. The collection was punctured using a cystotome and the FCSEMS inserted over a guidewire with fluoroscopic control. Repeat procedures were performed as necessary. <h3>Results</h3> A total of 11 patients (8 male, 3 female) were included in the study. Median age was 57.3 years. The aetiology of the collection was gallstones in 6 patients, idiopathic in 3, ischaemic in 1 and drug-induced in 1. Ten patients had evidence of at least 30% necrosis within the collection. Mean diameter of the collection was 15 cm and EUS-guided puncture was initially performed in all patients. The tract was dilated with a balloon in 6 patients. Stent insertion was either with a 20 mm (7 patients) or 30 mm (4 patients) length FCSEMS. Ten patients underwent endoscopic necrosectomy, with a median of 3 procedures (range 1–10). Significant reduction in the size of collection was achieved in all patients. Adverse events included stent migration in 3 (2 spontaneously and 1 during necrosectomy). Two patients died of complications of severe acute pancreatitis. <h3>Conclusion</h3> FCSEMS insertion is feasible and safe for drainage of pancreatic fluid collections. It allows repeated through the stent necrosectomy procedures and appears to be a major advance in the management of infected pancreatic necrosis. <h3>Disclosure of Interest</h3> None Declared.
A Comparison of Diets with and without Oats in Adults with Celiac Disease
Authors: Esko K. Janatuinen, Pekka H. Pikkarainen, Tarja A. Kemppainen, Veli-Matti Kosma, Ritva M.K. Järvinen, Matti I.J. Uusitupa, Risto J.K. Julkunen
Journal: New England Journal of Medicine (1995)

Wheat, rye, and barley damage the small-intestinal mucosa of patients with celiac disease; maize and rice are harmless. The effects of a diet containing oats are uncertain.
AB0504 Salivary Interleukin 6 in Primary Sjoegren's Syndrome Mo
Authors: A. Knopf, E. Drecoll, K. Becker, M. Bas, N. Mansour, B. Hofauer
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Primary Sjoegren9s syndrome (pSS) represents the most important rheumatic disease affecting the head and neck. Therapeutic regimes usually focus on a supportive therapy using saliva analogues. The progressive clinical course resulting in local complications as bacterial sialadenitis/abscesses, caries, parodontosis or severe dysphagia requires phase dependent therapeutic approaches. Literature lacks detailed assessment of potential biological markers that are able to monitor and modulate disease activity in pSS. <h3>Objectives</h3> To assess interleukin 6 (IL-6) as molecular marker to monitor disease activity and to analyze its molecular capacity in disease progression. <h3>Methods</h3> 70 patients were diagnosed with pSS according to the AECG criteria. All patients underwent major or minor salivary gland biopsy. IL-6 and related molecules were analyzed using ELISA and Luminex® magnetic bead technology for unstimulated saliva and by immunohistology for formalin fixes samples. Experimental data was related to subjective symptom score and objective clinical parameters that were obtained from all patients. <h3>Results</h3> Elevated IL-6 levels were diagnosed in pSS patients while serum IL-6 was regular. Analysis of subjective symptoms revealed a correlation among salivary IL-6 levels and xerostomia (p&lt;0.001) and dysphagia (p=0.038). Objective parameters as gustation test (p=0.001), Schirmer test (p=0.002), unstimulated whole saliva (p&lt;0.039) and lymphatic tissue infiltration (p=0.033) correlated with salivary IL-6 levels. Histological samples identified elevated IL-6 tissue infiltration for serous glandular parenchyma when compared with mixed glandular parenchyma. Patients with clinical disease progression showed rising salivary IL-6 levels and IL-6 levels levelled off during therapy. <h3>Conclusions</h3> IL-6 represents an unspecific but sensitive marker of glandular involvement in pSS that reliably monitors subjective and objective disease activity. Our data suggest IL-6 being a key molecule in molecular disease progression. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.5877
AB0015 Association between bdnf, ntrk2 and creb1 gene polymorphisms and fibromyalgia
Authors: S.-S. Nah, S. S. Jeong, S.-K. Kim, S.-H. Kim, Y.-A. Lee, J. H. Lee, S.-J. Hong, H.-S. Kim, H.-S. Lee, H. A. Kim, C.-I. Joung, H.-I. Yang, J.-W. Hur, S. H. Kim, S.-S. Lee
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Studies over the past 20 years have shown that fibromyalgia (FM) is a pain amplification disorder with clear evidence for a pathogenesis within the central nervous system. Brain-derived neurotrophic factor (BDNF) signaling pathway participates in plasticity mechanisms and serves as a neurotransmitter modulator. The pathway includes cyclic adenosine monophosphate response element-binding protein 1 (CREB1), BDNF, and its receptor (neurotrophic tyrosine kinase receptor, type 2 [NTRK2]). The variations of the genes were known to be associated with human neuropsychiatric disorders. <h3>Objectives</h3> We proposed to determine whether these BDNF-NTRK2-CREB1 pathway gene single nucleotide polymorphisms (SNPs) were associated with FM and/or any of its clinical variables. <h3>Methods</h3> Patients with FM (N = 422) and age-sex matched healthy normal controls (HNC, N = 410) were studied. Patients were carefully diagnosed by well trained rheumatologists at 13 tertiary hospitals. The SNPs were determined using Taq-Man analysis. In this study, three SNPs of <i>BDNF</i> (rs6265), <i>NTRK2</i> (rs1187323), and <i>CREB1</i> (rs2253206) genes were selected for the analysis. The patients and control groups were compared using case-control association analysis. The χ2 test was used to estimate the Hardy-Weinberg equilibrium (HWE). Allele frequency was defined as the percentage of the individuals carrying the allele among the total number of the individuals. Logistic regression analyses were used to calculate odds ratios (95% confidence interval). A P-value of less than 0.05 was considered to indicate statistical significance. <h3>Results</h3> Of the SNPs, <i>CREB1</i> gene SNP (rs2253206) is statistically associated with the susceptibility of FM. The <i>CREB1</i> SNP distribution was 150 (36%) GG, 204 (48%) GA, and 68 (16%) AA for HNC and 173 (42%) GG, 187(46%) GA, and 50 (12%) AA for HNC, respectively (<b>Table 1)</b>. <h3>Conclusions</h3> This is the first study to associate the BDNF-NTRK2-CREB1 pathway gene polymorphisms with FM and its subgroup phenotype. <h3>References</h3> Castren E, Voikar V, Rantamaki T (2006): Role of neurotrophic factors in depression. Curr Opin Pharmacol 7:18 –21. Duman RS, Monteggia LM (2006): A neurotrophic model for stressrelated mood disorders. Biol Psychiatry 59:1116 –1127. Carlson PJ, Singh JB, Zarate CA Jr, Drevets WC, Manji HK (2006): Neural circuitry and neuroplasticity in mood disorders: Insights for novel therapeutic targets. NeuroRx 3:22– 41. <h3>Disclosure of Interest</h3> None Declared
SP0016 A nurse led osteoarhtritis clinic in specialist care
Authors: S.M. Oliver
Journal: Annals of the Rheumatic Diseases (2013)

This presentation will outline the experiences of running a nurse led osteoarthritis clinic. A brief outline of the steps undertaken to prepare an appropriate business case will be outlined together with the challenges experienced in implementing the service in the UK healthcare system. This presentation will describe the benefits to the patients of providing a community based nurse led service as well as some of issues that must be considered for a successful and safe service. <h3>Disclosure of Interest</h3> None Declared
A case of Primary Duodenal Carcinoma which could be diagnosed presurgically by EUS-FNA
Authors: Ishikawa Hideki
Journal: Endoscopy (2011)

Background: Primary duodenal carcinoma is very rare, which has been experienced about almost 0.3% of total gastro-intestinal cancer in Japan. We experienced a case of primary duodenal cancer diagnosed through endoscopic ultrasound-guided fine needle aspiration biopsy (EUS-FNA) presurgically. EUS-FNA proved to be a safe and minimally invasive method to obtain a cyto logical and historogical diagnosis.
Time Trends in Incidence of Brain and Central Nervous System Cancers in Connecticut
Authors: A P Polednak
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Time Trends in Incidence of Brain and Central Nervous System Cancers in Connecticut Get access Anthony P. Polednak Anthony P. Polednak * * Correspondence to: Anthony P. Polednak, Ph.D., Department of Epidemiology and Public Health, Yale School of Medicine, 60 College St., P.O. Box 3333, New Haven, CT 06510. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 22, 20 November 1991, Pages 1679–1681, https://doi.org/10.1093/jnci/83.22.1679 Published: 20 November 1991 Article history Received: 08 May 1991 Revision received: 12 August 1991 Accepted: 28 August 1991 Published: 20 November 1991
Paradoxical cerebral embolism during endoscopic esophageal stenting in a patient with esophageal cancer
Authors: H. Kim, D. Kim, J. Hwang, W. Bae, S. Cho, Y. Joo, K. Choi, I. Chung, H. Shim
Journal: Endoscopy (2012)

A 77-year-old man with a recurrent esophageal cancer presented with progressive dysphagia. Computed tomography of the chest, esophagogastroscopy, and pharyngesophagography showed an approximately 8.3-cm long malignant stricture in the mid-esophagus ([Fig. 1]). A 10-cm long, esophageal self-expanding metallic stent (SEMS) was deployed under conscious sedation ([Fig. 2]). The patient's level of consciousness deteriorated immediately following the procedure, with left hemiparesis, decreased mentation, and dysarthria. Magnetic resonance imaging of the brain revealed acute cortical infarction ([Fig. 3]). Transcranial Doppler ultrasound with an agitated saline test demonstrated a patent foramen ovale (PFO). It was concluded that during the procedure the patient had a paradoxical tumor embolism via the PFO, causing multifocal cerebral infarction [1]. The patient was discharged with no improvement in his symptoms.
BENDAVIA (MTP-131), A NOVEL MITOCHONDRIA-TARGETING PEPTIDE, IMPROVES ACTIVITIES OF MITOCHONDRIA COMPLEX-I AND COMPLEX-IV IN LEFT VENTRICULAR MYOCARDIUM OF DOGS WITH ADVANCED HEART FAILURE
Authors: Hani N. Sabbah, Ramesh C. Gupta, Sharad Rastogi, Mengjun Wang, Kefei Zhang, Paula Mohyi, Kristina J. Szekely
Journal: Journal of the American College of Cardiology (2014)
P764 ANALYSIS OF THE EFFECT OF CYCLOPHILIN INHIBITOR ALISPORIVIR ON THE INTERFERON RESPONSE IN HCV-INFECTED CELLS AND PATIENTS
Authors: M. Bobardt, J. Baugh, P. Gallay, S. Ma, S. Kaiser, N. Hartmann, M. Letzkus, F. Staedtler, A. Riva, S. Chokshi, N.R. Nirmala, K.J. Johnson, C.A. Brass, N.V. Naoumov, B. Li
Journal: Journal of Hepatology (2014)
FRI0241 Association of gastroesophageal factors and progression of interstitial lung disease in the canadian scleroderma research group (CSRG); a large, multi-center database:
Authors: X.J. Zhang, A. Bonner, M. Baron, M. Hudson, J.E. Pope
Journal: Annals of the Rheumatic Diseases (2012)

<h3>Background</h3> Interstitial lung disease (ILD) is a common complication of systemic sclerosis (SSc) and is a leading contributor to mortality in SSc patients. Once lung fibrosis occurs, lung function disease course may become stable or progressively decline. While some demographic and SSc-related factors have been associated with development of ILD, little is known about what contributes to progression. We studied the clinical manifestations of SSc-gastroesophageal (GE) involvement in relation to ILD status to determine associations between GE involvement and ILD progression in SSc. <h3>Objectives</h3> To determine if GE reflux and dysphagia are associated with progressive ILD as measured by PFTs over three years. <h3>Methods</h3> Canadian Scleroderma Research Group (CSRG), a multi-center database of adult SSc patients, annually evaluates and collects patient information including demographics, skin manifestations, internal organ involvement and function assessment data. Using indicators of GE involvement and annual pulmonary function test results from the CSRG database, comparisons were made between no ILD, stable ILD and progressive ILD groups based on FVC% predicted. Univariate and multivariate analysis were used to determine association between GE factors and ILD development and progression. <h3>Results</h3> The study included data of 1043 SSc patients with mean age of 55.7 years and mean disease duration of 10.8 years. Among the variables of interest, physician indicators such as esophageal dysmotility (P=0.009) and post-esophageal dilatation (P=0.041) along with patient indicators such as difficulty swallowing (P=0.016), waking up choking (P=0.026) appeared to significantly increase risk of developing ILD. In comparing progressive vs. stable ILD patients, early satiety (p=0.018) a combination term composed of post-dilatation*choking (p=0.042) increased risk of ILD progression. <h3>Conclusions</h3> Indicators of esophageal dysmotility and GERD studied appear to be associated with ILD in SSc, with some factors specifically related to progressive ILD. Further, the strong association of an interaction term of both dysmotility and GERD with progressive ILD illustrates a potential dose-response phenomenon. These results hold important implications for management of ILD in SSc. <h3>Disclosure of Interest</h3> X. Zhang Grant/Research support from: Canadian Scleroderma Research Group Summer Studentship, CIHR Net Training Grant, A. Bonner: None Declared, M. Baron: None Declared, M. Hudson: None Declared, J. Pope Grant/Research support from: CIHR, Scleroderma Society of Canada, Scleroderma Society of Ontario
IM-06 * A BIOINFORMATICS EVALUATION OF TUMOR-ASSOCIATED MACROPHAGES ACROSS 2 BRAIN TUMOR TYPES
Authors: W.-Y. Teo, S. Karthik, S. V. Pratap, X. Li, J. Shen, M. T. Elghetany, K.-M. Hui, C. C. Lau
Journal: Neuro-Oncology (2015)

BACKGROUND: CD163, the membrane form of a M2 macrophage marker, is exclusively expressed on alternatively activated or M2 macrophages. In some tumors such as neuroblastoma, CD163+ tumor-associated macrophages (TAMs) were shown to correlate with metastatic disease, age and outcome. Recently, the presence of TAMs has been demonstrated in some brain tumors, with evidence of origins from monocyte-derived macrophages from peripheral blood, and not brain resident microglial. AIM: (1) To evaluate CD163 expression using gene expression data, in 2 brain tumor types, medulloblastoma (MB) and glioblastoma multiforme (GBM); (2) To correlate CD163 expression with prognostic outcome in MBs and GBMs. METHODS: We analyzed CD163 gene expression in MBs (n = 60, Affymetrix U133 plus 2.0 platform) from Texas Children's Cancer Center and GBMs from TCGA dataset (n = 168, RNA sequencing). RESULTS: Previously, we provided evidence that the quantitative expression of CD163, indicative of CD163+ TAMs infiltration, was distinct among molecular subtypes of MBs, Sonic-Hedgehog-activated tumors were the most enriched (p = 0.006). We further discovered that CD163 expression was also distinct among molecular subtypes of GBMs, with Mesenchymal subtype being most enriched (p = 0.0006). CONCLUSIONS: These findings highlight the therapeutic implications on the pathogenesis role and therapeutic targeting aspects of CD163+ macrophages in different molecular subtypes of 2 brain tumor types. M2 macrophages serve a greater regulatory function than effector killing function associated with classically activated macrophages. IL10 secreted by M2 macrophages are also implicated in angiogenesis necessary for tumor growth and proliferation. In addition, TAMs cross-present tumor-derived endogenous ligands and can be specifically recognized and killed by natural-killer-T-cells.
PWE-083 Distinguishing Between Possible Mental Health Disorders And Psychological Distress By Screening For Acceptance And Adjustment Issues
Authors: N Swart, D Wellsted, K Friedli, G Wood, T Price, K Lithgo, M Johnson
Journal: Gut (2014)

<h3>Introduction</h3> A recent study indicated that 30% of IBD patients suffer from psychological distress, and that poor acceptance and adjustment is a predictor of distress (Swart <i>et al</i>. 2013). Psychological distress encompasses the symptoms of depression, anxiety, emotional difficulty and poor adjustment, but is not the same as mental illnesses such as Major Depressive Disorder or Generalised Anxiety Disorder. Early indications suggest IBD patients are particularly susceptible to adjustment disorders, which may be the cause of much distress. <h3>Methods</h3> As part of a service evaluation, 2400 IBD patients in the Luton and Dunstable catchment area were invited to participate in a web-based psychological and quality of life assessment. The “Acceptance and Action Questionnaire” (AAQ-II) was used for acceptance/adjustment, as well as the “Patient Health Questionnaire” (PHQ-9) for depression, and the “Generalised Anxiety Disorder Questionnaire” (GAD-7) for anxiety. <h3>Results</h3> 360 patients completed the assessment (45% male, mean age = 53; SD = 17). 31% of patients scored highly on the PHQ-9; 27% of patients scored highly on the GAD-7; and 27% of patients also scored highly on the AAQ-II. Linear regression, after taking account of relevant clinical factors, showed that poor acceptance was associated with high depression and anxiety. Cross tabulation indicated 20% of patients showed high depression and poor acceptance, and 11% of patients showed high depression and good acceptance/adjustment. Anxiety sees a similar picture with 18% high anxiety and poor acceptance/adjustment, and 8% high anxiety and good acceptance/adjustment. <h3>Conclusion</h3> The self-report prevalence rates of depression and anxiety we found are typical of chronic illness poplations, however the cross-tabulation results suggest a more complex picture. While further research is needed, theory suggests those 20% are struggling with depression which stems from their acceptance and adjustment issues. Similarly, those 11% with high depression and good acceptance are likely to have a mental health disorder like Major Depressive Disorder – 11% is a similar prevalence rate found when using diagnostic interviews. These groups of patients would likely benefit most from different treatment paths. Specifically, severe depressive symptoms stemming from acceptance/adjustment issues would likely benefit more from Acceptance and Commitment Therapy than standard procedures for treatment of depression with antidepressants and Cognitive Behavioural Therapy. <h3>Reference</h3> Swart N, Wellsted D, Lithgo K, Price T, Johnson MW. PWE-110 acceptance and adjustment in a district general cohort of inflammatory bowel disease patients: findings and implications. <i>Gut </i>2013;62:A175–A176 <h3>Disclosure of Interest</h3> None Declared.
Abstract 3358: 1α,25-dihydroxyvitamin D3 inhibits the proliferation of cultured glioblastoma multiforme cells
Authors: Justine M. Pinskey, Robert J. Winn
Journal: Cancer Research (2012)

Abstract Glioblastoma multiforme (GBM) is a common, aggressive type of brain tumor with a median survival of only fifteen months. Brain tumor stem cells (BTSCs) within GBM tumors resist standard treatments, initiate recurrence, and pose a significant challenge for GBM treatment. This study examined Gli1 expression and proliferation of GBM cells in vitro to evaluate the effects of 1α,25-dihydroxyvitamin D3 (vitamin D3). Vitamin D3 is a safe, natural inhibitor of the hedgehog signaling pathway–a mechanism essential to BTSC function. Immunocytochemistry demonstrated that both established GBM cell lines and GBM-derived BTSCs expressed Gli1, indicating hedgehog signaling pathway activity within the cell populations. Vitamin D3 treatment significantly reduced cell proliferation, both in GBM cell lines and GBM-derived BTSCs. Because of active vitamin D3's environmental instability, an in vivo model might provide a better indication of its anti-tumor effects. Ultimately, vitamin D3 may enhance standard GBM treatments by inhibiting hedgehog-expressing cells. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3358. doi:1538-7445.AM2012-3358
Comparison of in vitro apoptosis induction by alpha-irradiation versus gamma-irradiation in B-CLL
Authors: Fritz Offner, Filip De Vos, K Vandenbulcke, Ann Janssens, R Molinet, C Apostolidis, W Janssens, T Nikula, Christophe Lahorte, B Brans, Guido Slegers, Hubert Thierens, Rudi Dierckx, Jan Philippé
Journal: Blood (2001)
649 A PROSPECTIVE COHORT STUDY OF MULTIPLE RISK FACTORS AND AGE AT ONSET OF HEPATOCELLULAR CARCINOMA IN HEPATITIS B VIRUS CARRIERS
Authors: Y.-C. Hung, C.-L. Lin, C.-J. Liu, C.-J. Chen, Y.-F. Liaw, H.-C. Chang, S.-M. Lin, S.-D. Lee, P.-J. Chen, M.-W. Yu
Journal: Journal of Hepatology (2013)
Judah Leon Morris
Authors: D. Skehan, M. Skehan
Journal: BMJ (2011)

Judah Leon Morris lived in South Africa, where he qualified at the age of just 21. After early training he came to London for periods of radiology training and returned permanently in 1957, disillusioned by the sociopolitical situation in South Africa. He took up consultant practice in Woolwich and then at The London Hospital to concentrate …