tbuckley/cabot-search huggingface dataset:
Endometriosis Under Estradiol Stimulation Imaged Using 18F-FDG and Its Control After Estradiol Cessation and Progesterone Hormonal Replacement
Authors: Frédéric Arsenault, Éric Turcotte
Journal: Clinical Nuclear Medicine (2015)

Endometriosis is a frequent and benign cause of disabling abdominal pain, for which a diagnosis suspicion is clinically raised, but its confirmation necessitates a surgical exploration by laparoscopy. Foci of endometriosis proliferate under estrogen stimulation, like normal endometrium. We present a patient under estradiol stimulation for a history of endometrial cancer who underwent a PET/CT scan to assess an abdominal lesion showing a high F-FDG uptake, which normalized under progesterone hormonal replacement and cessation of estradiol. Two consecutive biopsies confirmed endometriosis. F-FDG evaluation of endometriosis under estrogen stimulation could be a promising approach to refractory endometriosis assessment.
Diagnosis of antisocial personality disorder in two prison populations
Authors: R D Hare
Journal: American Journal of Psychiatry (1983)

The author presents data on the incidence and reliability of the DSM-III diagnosis of antisocial personality disorder in 246 male inmates of two prisons, comparing this diagnosis with assessment procedures that have proven useful in the study of psychopathy. He found good agreement between the diagnosis of antisocial personality disorder and assessments of psychopathy, although DSM-III did not readily identify individuals who fit the classic picture of psychopathy but avoided early contact with the judicial system. Nevertheless, DSM-III may be useful for differential diagnosis in criminal populations.
A comparison of videotaped and live patient interview examinations and written examination in psychiatry
Authors: D H Naftulin, G H Wolkon, F A Donnelly, R W Burgoyne, F M Kline, H E Hansen
Journal: American Journal of Psychiatry (1977)

The authors scored the examination performance of 28 psychiatrists who were tested after conducting an interview with a real patient and after seeing a videotaped interview with an actor playing the role of either a psychotic or a neurotic patient. The also scored the performance of 15 of the same examinees who completed a written examination. Eighty-five percent of the examinees reported that the videotaped interview examination was a useful learning experience, and 81% said that it was a useful testing experience. The examiners' feelings varied regarding the use of the standardized videotaped format for certification and recertification of psychiatrists.
M.D. Anderson Tribute: Texas' World Class Cancer Center Builds on First 50 Years
Authors: G McBride, J Waalen
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article M.D. Anderson Tribute : Texas' World Class Cancer Center Builds on First 50 Years Get access JNCI: Journal of the National Cancer Institute, Volume 83, Issue 10, 15 May 1991, Pages 671–675, https://doi.org/10.1093/jnci/83.10.671 Published: 15 May 1991
Benefits of, and barriers to, reactivating dormant trials
Authors: Ruth Gilbert, Katie Harron, Lorraine Dearden
Journal: BMJ (2015)

The UK should follow Ontario and reactivate its treasure trove of dormant trials to generate new science through linkage with administrative data.1 Many groups stand to benefit. For example, drug regulators could encourage linkage of dormant and new trials to administrative data to monitor long term safety of drugs.2 Linkage would also lead to better evidence on the long …
Brexit—not EU membership—threatens the NHS, 60 eminent doctors say
Authors: Zosia Kmietowicz
Journal: BMJ (2016)

Sixty eminent doctors have warned that citizens of the UK will lose out in terms of health and welfare if the country votes to leave the European Union (EU) next week, with their health and the future of the NHS at risk.1

In a letter to the Times , the former presidents and chairs of medical royal colleges and the BMA set out …
Non-Transplant Therapy for Older Adults with Acute Myeloid Leukemia
Authors: Mikkael A. Sekeres
Journal: Journal of the National Comprehensive Cancer Network (2006)

Acute myeloid leukemia is a disease of older adults, with a median age at diagnosis of 68 years. This group represents a high-risk population, because inherent disease characteristics predict for resistance to chemotherapy and advanced age is accompanied by high treatment-related mortality. Standard remission-induction and postremission therapy can result in a median disease-free survival of 10 months and rare long-term survival. Efforts to improve outcomes have not made a major impact on complete remission rates of 40% to 60%, or on overall survival. Newer therapies, divided into aggressive and nonaggressive approaches, focus on targeting the disease biology specific to older adults and on maximizing quality of life. Clinical trials should be considered at every stage of treatment in this group of patients.
RO-12CRANIOSPINAL IRRADIATION IN CHILDREN WITH HIGH-RISK MEDULLOBLASTOMA: HAEMATOLOGICAL TOXICITY AND RISK FACTORS
Authors: Francois-Georges Riet, Stéphanie Bolle, Caroline Brard, Anne Beaudre, Anais Jouin-Bortolotti, Bernard Coche-Dequeant, Anne Laprie, Laetitia Padovani, Marc-André Mahe, Christelle Dufour
Journal: Neuro-Oncology (2016)
Evaluation of predictive biomarkers of response and prognosis in patients with high-grade extrapulmonary neuroendocrine carcinomas treated with platin-based chemotherapy.
Authors: Juliana Florinda De Mendonga Rego, Raphael Salles S. Medeiros, Maria Ignez Freitas Melro Braghiroli, Joao Evangelista Bezerra Neto, Rodrigo Ramella Munhoz, Juliana Mariotti Guerra, Lidia Kimura, Suely Nonogaki, Tulio Eduardo Flesch Pfiffer, Breno Galvao, Paulo Marcelo Hoff, Duilio Rocha Filho, Frederico Costa, Rachel Pimenta Riechelmann
Journal: Journal of Clinical Oncology (2015)

e15183 Background: High-grade extrapulmonary neuroendocrine carcinomas (EPNEC) comprise a rare, aggressive and heterogeneous group of neoplasms. Most patients (pts) are metastatic and have shorter survival compared with others neuroendocrine tumors. Tissues markers could help tailoring systemic therapy to improve response rate (RR) to chemotherapy (Cx) and overall survival (OS). Methods: We conducted a retrospective analysis of pts with advanced high-grade EPNECs treated with platinum-based chemotherapy. Pts had their paraffin-embedded tumor tissues tested for Ki67, ERCC-1, BCL2 and Lin-28a by immunohistochemistry (IHC). All samples were reviewed by the same pathologist (R.S.S.M.). A final H-score was obtained multiplying the intensity of positive staining (0-3) by the percentage of positive cells (0-100), ranging 0-300. A H-score > = 200 was considered positive. Biomarkers were analyzed as both categorical and continuous variables. A cut of 55% was used to test Ki67 expression as a categorical variable. RR was measured by RECIST 1.1. OS was defined as the time from the first cycle of Cx until death and estimated with the Kaplan-Meier method. Association between biomarkers expression and RR was assessed using chi-square or Fisher’s exact test for categorical variables and simple logistic regression for continuous variables. Results: From July 2006 to July 2014, 60 pts were identified: N = 34 (56.7%) were males, the median age was 55 yo (23-81), with 45 (75%) being of gastrointestinal origin. The median Ki67 was 50% (20-95%). At baseline N = 45 (75%) had an ECOG-PS 0 or 1. Pts received a median of 5 cycles (1-10). The median OS was 12.3 months. Among 56 patients who were evaluable for response, the RR was 44.6%. Bcl-2, ERCC1 and Lin28a were IHC positive in N = 17 (28.3%), N = 49 (81.7%), and N = 35 (59.3%) cases, respectively. Neither biomarker, including ki67, was prognostic or predictive of response to Cx. Conclusions: Despite prior evidence that ERCC1, Lin28a, BLC2 and ki67 influenced the response to Cx in many solid tumors, we could not identify any predictive or prognostic role of these markers in EPNECs pts treated with platin-based chemotherapy.
Reverse transcriptase-polymerase chain reaction and islet cell carcinoma: not antagonist, but complementary tools.
Authors: J Benhattar, L Perey, R Peters, S Leyvraz
Journal: Journal of Clinical Oncology (1998)

Article Tools Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.1998.16.2.806 Journal of Clinical Oncology - published online before print September 21, 2016 PMID: 9469379 Reverse transcriptase-polymerase chain reaction and islet cell carcinoma: not antagonist, but complementary tools. J BenhattarxJ BenhattarSearch for articles by this author , L PereyxL PereySearch for articles by this author , R PetersxR PetersSearch for articles by this author , S LeyvrazxS LeyvrazSearch for articles by this author https://doi.org/10.1200/JCO.1998.16.2.806 PDF "Reverse transcriptase-polymerase chain reaction and islet cell carcinoma: not antagonist, but complementary tools.." Journal of Clinical Oncology, 16(2), pp. 806–807© 1998 by American Society of Clinical Oncology
Frequency of Tobacco Use Among Middle and High School Students — United States, 2014
Authors: Linda J. Neff, René A. Arrazola, Ralph S. Caraballo, Catherine G. Corey, Shanna Cox, Brian A. King, Conrad J. Choiniere, Corinne G. Husten
Journal: MMWR Morbidity and Mortality Weekly Report (2015)

The use of tobacco products during adolescence increases the risk for adverse health effects and lifelong nicotine addiction. In 2014, an estimated 4.6 million middle and high school students were current users of any tobacco product, of whom an estimated 2.2 million were current users of two or more types of tobacco products. Symptoms of nicotine dependence are increased for multiple tobacco product users compared with single-product users. CDC and the Food and Drug Administration (FDA) analyzed data from the 2014 National Youth Tobacco Survey (NYTS) to determine how frequently (the number of days in the preceding 30 days) U.S. middle school (grades 6–8) and high school (grades 9–12) students used cigarettes, e-cigarettes, cigars, and smokeless tobacco products. Among current users (≥1 day during the preceding 30 days) in high school, frequent use (≥20 days during the preceding 30 days) was most prevalent among smokeless tobacco users (42.0%), followed by cigarette smokers (31.6%), e-cigarette users (15.5%), and cigar smokers (13.1%); a similar pattern was observed for those who used during all 30 days. Among current users in middle school, frequent use was greatest among smokeless tobacco users (29.2%), followed by cigarette smokers (20.0%), cigar smokers (13.2%) and e-cigarette users (11.8%). Current use of two or more types of tobacco products was common, even among students who used tobacco products 1–5 days during the preceding 30 days: 77.3% for cigar smokers, 76.9% for cigarette smokers, 63.4% for smokeless tobacco users, and 54.8% for e-cigarettes users. Preventing youths from initiating the use of any tobacco product is important to tobacco use prevention and control strategies in the United States. Monitoring the frequency and patterns of tobacco use among youths, including the use of two or more tobacco products, is important to inform evidence-based interventions to prevent and reduce all forms of tobacco use among youths.
Prevalence of chronic liver disease and cirrhosis by underlying cause in understudied ethnic groups: The multiethnic cohort
Authors: Veronica Wendy Setiawan, Daniel O. Stram, Jacqueline Porcel, Shelly C. Lu, Loïc Le Marchand, Mazen Noureddin
Journal: Hepatology (2016)

Chronic liver disease (CLD) and cirrhosis are major sources of morbidity and mortality in the United States. Little is known about the epidemiology of these two diseases in ethnic minority populations in the United States. We examined the prevalence of CLD and cirrhosis by underlying etiologies among African Americans, Native Hawaiians, Japanese Americans, Latinos, and whites in the Multiethnic Cohort. CLD and cirrhosis cases were identified using Medicare claims between 1999 and 2012 among the fee‐for‐service participants (n = 106,458). We used International Classification of Diseases Ninth Revision codes, body mass index, history of diabetes mellitus, and alcohol consumption from questionnaires to identify underlying etiologies. A total of 5,783 CLD (3,575 CLD without cirrhosis and 2,208 cirrhosis) cases were identified. The prevalence of CLD ranged from 3.9% in African Americans and Native Hawaiians to 4.1% in whites, 6.7% in Latinos, and 6.9% in Japanese. Nonalcoholic fatty liver disease (NAFLD) was the most common cause of CLD in all ethnic groups combined (52%), followed by alcoholic liver disease (21%). NAFLD was the most common cause of cirrhosis in the entire cohort. By ethnicity, NAFLD was the most common cause of cirrhosis in Japanese Americans, Native Hawaiians, and Latinos, accounting for 32% of cases. Alcoholic liver disease was the most common cause of cirrhosis in whites (38.2%), while hepatitis C virus was the most common cause in African Americans (29.8%). Conclusions: We showed racial/ethnic variations in the prevalence of CLD and cirrhosis by underlying etiology; NAFLD was the most common cause of CLD and cirrhosis in the entire cohort, and the high prevalence of NAFLD among Japanese Americans and Native Hawaiians is a novel finding, warranting further studies to elucidate the causes. (H epatology 2016;64:1969‐1977)
EPN-38RELAPSE PATTERNS IN PEDIATRIC INTRACRANIAL EPENDYMOMA: A CANADIAN EXPERIENCE
Authors: Tanya Brown, Tamir Ailon, Uri Tabori, Lucie Lafay-Cousin, Beverly Wilson, Daniel McNeely, Shayna Zelcer, Donna Johnston, Marianna Silver, Anne-Sophie Carret, David Eisenstat, Katrin Scheinemann,, Nada Jabado, Tami Yamashita, Cynthia Hawkins, Karen Goddard, Christopher Dunham, Juliette Hukin
Journal: Neuro-Oncology (2016)
LG-57LOW GRADE GLIOMA (LGG) IN ADOLESCENTS. EXPERIENCE FROM ONE CENTER
Authors: Ewa Swieszkowska, Monika Drogosiewicz, Marta Perek-Polnik, Iwona Filipek, Agnieszka Brozyna, Wieslawa Grajkowska, Marcin Roszkowski, Bozenna Dembowska-Baginska
Journal: Neuro-Oncology (2016)
Case 21-1970
Authors: Richard C. Cabot, Benjamin Castleman, Betty U. McNeely, Simeon Locke, Joel Umlas
Journal: New England Journal of Medicine (1970)

Presentation of CaseA nineteen-year-old man was admitted to the hospital for evaluation of a progressive neuropathy.He had been well until twenty months previously, when there was the onset of muscular weakness and intermittent swelling and cyanosis in the left hand, and one month later blisters appeared on the left hand. Seventeen months before admission the left fingers began to assume a flexed position. Three months later he burned both hands on a hot pan, without awareness of pain. At that time he experienced sharp pain in the soles of both feet while walking. During the succeeding months the . . .
Zika Virus Disease in Colombia — Preliminary Report
Authors: Oscar Pacheco, Mauricio Beltrán, Christina A. Nelson, Diana Valencia, Natalia Tolosa, Sherry L. Farr, Ana V. Padilla, Van T. Tong, Esther L. Cuevas, Andrés Espinosa-Bode, Lissethe Pardo, Angélica Rico, Jennita Reefhuis, Maritza González, Marcela Mercado, Pablo Chaparro, Mancel Martínez Duran, Carol Y. Rao, María M. Muñoz, Ann M. Powers, Claudia Cuéllar, Rita Helfand, Claudia Huguett, Denise J. Jamieson, Margaret A. Honein, Martha L. Ospina Martínez
Journal: New England Journal of Medicine (2016)

Colombia began official surveillance for Zika virus disease (ZVD) in August 2015. In October 2015, an outbreak of ZVD was declared after laboratory-confirmed disease was identified in nine patients.Using the national population-based surveillance system, we assessed patients with clinical symptoms of ZVD from August 9, 2015, to April 2, 2016. Laboratory test results and pregnancy outcomes were evaluated for a subgroup of pregnant women. Concurrently, we investigated reports of microcephaly for evidence of congenital ZVD.By April 2, 2016, there were 65,726 cases of ZVD reported in Colombia, of which 2485 (4%) were confirmed by means of reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay. The overall reported incidence of ZVD among female patients was twice that in male patients. A total of 11,944 pregnant women with ZVD were reported in Colombia, with 1484 (12%) of these cases confirmed on RT-PCR assay. In a subgroup of 1850 pregnant women, more than 90% of women who were reportedly infected during the third trimester had given birth, and no infants with apparent abnormalities, including microcephaly, have been identified. A majority of the women who contracted ZVD in the first or second trimester were still pregnant at the time of this report. Among the cases of microcephaly investigated from January 2016 through April 2016, four patients had laboratory evidence of congenital ZVD; all were born to asymptomatic mothers who were not included in the ZVD surveillance system.Preliminary surveillance data in Colombia suggest that maternal infection with the Zika virus during the third trimester of pregnancy is not linked to structural abnormalities in the fetus. However, the monitoring of the effect of ZVD on pregnant women in Colombia is ongoing. (Funded by Colombian Instituto Nacional de Salud and the Centers for Disease Control and Prevention.).
Green Tea Catechin-Based Complex Micelles Combined with Doxorubicin to Overcome Cardiotoxicity and Multidrug Resistance
Authors: Tangjian Cheng, Jinjian Liu, Jie Ren, Fan Huang, Hanlin Ou, Yuxun Ding, Yumin Zhang, Rujiang Ma, Yingli An, Jianfeng Liu, Linqi Shi
Journal: Theranostics (2016)

Chemotherapy for cancer treatment has been demonstrated to cause some side effects on healthy tissues and multidrug resistance of the tumor cells, which greatly limits therapeutic efficacy.To address these limitations and achieve better therapeutic efficacy, combination therapy based on nanoparticle platforms provides a promising approach through delivering different agents simultaneously to the same destination with synergistic effect.In this study, a novel green tea catechin-based polyion complex (PIC) micelle loaded with doxorubicin (DOX) and (-)-Epigallocatechin-3-O-gallate (EGCG) was constructed through electrostatic interaction and phenylboronic acid-catechol interaction between poly(ethylene glycol)-block-poly(lysine-co-lysine-phenylboronic acid) (PEG-PLys/PBA) and EGCG.DOX was co-loaded in the PIC micelles through π-π stacking interaction with EGCG.The phenylboronic acid-catechol interaction endowed the PIC micelles with high stability under physiological condition.Moreover, acid cleavability of phenylboronic acid-catechol interaction in the micelle core has significant benefits for delivering EGCG and DOX to same destination with synergistic effects.In addition, benefiting from the oxygen free radicals scavenging activity of EGCG, combination therapy with EGCG and DOX in the micelle core could protect the cardiomyocytes from DOX-mediated cardiotoxicity according to the histopathologic analysis of hearts.Attributed to modulation of EGCG on P-glycoprotein (P-gp) activity, this kind of PIC micelles could effectively reverse multidrug resistance of cancer cells.These results suggested that EGCG based PIC micelles could effectively overcome DOX induced cardiotoxicity and multidrug resistance.
On the Factor of Age in the Production of Subcutaneous Sarcomas in Mice by 20-Methylcholanthrene
Authors: Erkki A. Saxén, M.D.
Journal: JNCI Journal of the National Cancer Institute (1953)

On the Factor of Age in the Production of Subcutaneous Sarcomas in Mice by 20-Methylcholanthrene Get access Erkki A. Saxén, M.D. Erkki A. Saxén, M.D. Research Fellow National Cancer Institute,3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 14, Issue 3, December 1953, Pages 547–569, https://doi.org/10.1093/jnci/14.3.547 Published: 01 December 1953 Article history Received: 08 June 1953 Published: 01 December 1953
Histogenetic Classification of Induced Gastric Sarcomas in Mice
Authors: Erkki A. Saxén, Harold L. Stewart
Journal: JNCI Journal of the National Cancer Institute (1952)

Histogenetic Classification of Induced Gastric Sarcomas in Mice Get access Erkki A. Saxén, Erkki A. Saxén Search for other works by this author on: Oxford Academic PubMed Google Scholar Harold L. Stewart Harold L. Stewart Laboratory of Pathology, National Cancer Institute3Bethesda, Md. Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 13, Issue 3, December 1952, Pages 657–679, https://doi.org/10.1093/jnci/13.3.657 Published: 01 December 1952 Article history Received: 16 July 1952 Published: 01 December 1952
The Chromosomes and Transplantability of Tumors. II. Chromosome Duplication and the Loss of Strain Specificity in Solid Tumors
Authors: L SACHS, R GALLILY
Journal: JNCI Journal of the National Cancer Institute (1956)

Journal Article The Chromosomes and Transplantability of Tumors. II. Chromosome Duplication and the Loss of Strain Specificity in Solid Tumors Get access Leo Sachs, Leo Sachs Department of Experimental Biology, Weizmann Institute of Science, Rehovoth, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar Ruth Gallily Ruth Gallily Department of Experimental Biology, Weizmann Institute of Science, Rehovoth, Israel Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 16, Issue 4, February 1956, Pages 803–841, https://doi.org/10.1093/jnci/16.4.803 Published: 01 February 1956 Article history Received: 28 June 1955 Published: 01 February 1956
A memorable patient: Miss Fortitude
Authors: David Scarfe
Journal: BMJ (2005)

When I took her on as my patient, she made it clear that she did not hold the medical profession in high regard. She had worked for many years in a medical students' hostel and had seen us with our youthful exuberance and excesses. She now lived alone on the 10th floor of a tower block, and I always ended my visits to her going to the window to admire the magnificent view over the city.

Her body was crumbling: she was confined to a chair with an osteoporotic spine, and her neck seemed to have collapsed so that her head apparently sprouted from her upper chest at a crazy angle. Yet her mind remained as sharp as a pin: she was constantly pointing out my mistakes or omissions, much to my embarrassment. Our discussions about her treatment and conditions felt more like discussions with a colleague rather than with a patient.

The only family was a nephew in another town, represented by a photograph from the 1970s, the colours taking on strange hues as the event it depicted faded into the past. I was curious to know why she hadn't married, but it would have been inappropriate to ask and I never did.

I had respect and affection for her. Despite her isolation and frailty, she never complained. She rarely bothered us at the surgery, and if she requested a visit I was pleased to go, knowing that it was justified. On her 90th birthday, I took her a card—something I have never done before or since for a patient—knowing that few others would be celebrating that great achievement.

One day, while working for the out of hours service, I received a request to visit. On my arrival it was clear that she was seriously ill and barely comprehensible. There was only one place for her. As I spoke to the admitting doctor on the telephone, I noticed a movement from the corner of my eye. Her arm was moving slowly from a flexed to an almost extended position. Then her body was motionless. After checking her, I told the admitting officer that I would not be sending her in after all.

I felt honoured to have been present with this remarkable woman, my patient and friend, when her life ebbed away.