tbuckley/cabot-search huggingface dataset:
Preventive Medicine: Principles of Prevention in the Occurrence and Progression of Disease.
Journal: Annals of Internal Medicine (1965)

not to accept the offer because of his age of 63 years.This was no doubt a very difficult thing for Dr. Richardson to do because there could not have been anything that he would rather have had happen to him, if only it could have come at a better time in his life.Another point of interest is the vehemence with which he expresses his dislike
VEGF and AMD3100-Induced Rapid Mobilization of C-Kit/Sca-1 Positive Murine Bone Marrow Cells and of Gr-1+/CD-11b+ Myeloid Cells Is Impaired in Urokinase (uPA) and Urokinase Receptor (uPAR) Deficient Mice.
Authors: Mohammad Dehghani, Damla Olcaydu, Pavel Uhrin, Bernd Binder, Johannes Breuss
Journal: Blood (2008)
Regarding ‘Frontal fibrosing alopecia: possible association with leave-on facial skincare products and sunscreens; a questionnaire study’
Authors: A. Dhana, F. Gumedze, N.P. Khumalo
Journal: British Journal of Dermatology (2016)

Using a matched case-control study design, Aldoori et al (2016) report a possible association between frontal fibrosing alopecia (FFA) and the regular use of sunscreens and facial skin care products.1 We commended the authors for drawing attention to potential environmental causes of this disfiguring condition. However, several methodological limitations drew our attention.

First, we are concerned about selection bias. Control subjects were selected from hospital staff through advertisements and from friends and family of the authors. Ideally, controls should be randomly sampled from the source population that gave rise to cases.

This article is protected by copyright. All rights reserved.
Quality of Life in a 2-Year Follow-up: Signs of PNP Predicting Cognitive Functioning in Survivors Treated in the HD10–12 Trials of the German Hodgkin Study Group (GHSG).
Authors: Teresa Halbsguth, Horst Mueller, Hans-Henning Flechtner, Corinne Brillant, Karolin Behringer, Thomas Schober, Hiltrud Nisters-Backes, Andreas Engert, Peter Borchmann
Journal: Blood (2008)
Efficacy and safety of the SQ house dust mite sublingual immunotherapy tablet in Japanese adults and adolescents with house dust mite–induced allergic rhinitis
Authors: Kimihiro Okubo, Keisuke Masuyama, Toru Imai, Kazuhiro Okamiya, Brian Sonne Stage, Dorthe Seitzberg, Akiyoshi Konno
Journal: Journal of Allergy and Clinical Immunology (2016)
Tacrolimus Metabolism and Risk of Acute Graft Versus Host Disease
Authors: Mary Christa Krupski, Andrew Bodiford, Kathryn Culos, Adetola A. Kassim, Brian G. Engelhardt, John P. Greer, Bipin N. Savani, Wichai Chinratanalab, Madan Jagasia
Journal: Blood (2015)
THU0362 Adverse Pregnancy Outcomes and Associated Factors in Patients with Systemic Lupus Erythematosus
Authors: Z. Zhan, D. Chen, Y. Yang, L. Liang
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Compared to the general population, pregnant women with systemic lupus erythematosus (SLE) tended to suffer a higher risk of adverse pregnancy outcomes (APOs). Since SLE often affected women of reproductive age, pregnancy outcomes and the associated factors had always been a major concern. <h3>Objectives</h3> To investigate the maternal and fetal outcomes among pregnant patients with SLE, and to evaluate the clinical predictors of adverse pregnancy outcomes. <h3>Methods</h3> We collected the clinical data from 251 SLE patients with 263 pregnancies between Jan 2001 to Dec 2015 and then conducted retrospective analysis. APOs included pregnancy loss (spontaneous or therapeutic abortion, fetal death, and neonatal death), adverse fetal outcomes [fetal malformation, preterm delivery, and neonatal lupus erythematosus (NLE)], obstetrical complications [pregnancy induced hypertension (PIH), intrauterine growth retardation (IUGR), and fetal distress]. Associated factors for APOs were analyzed by Logistic regression model. <h3>Results</h3> The mean age of patients was 28.6±3.9 yrs, apart from newly diagnosed ones, the mean duration was 5.8±4.0 yrs. Of all the 263 pregnancies, 188 were from previously diagnosed SLE patients and 75 were from newly diagnosed (during pregnancy or puerperium) patients. Successful delivery and pregnancy loss occurred in 71.5% (188/263) and 29.5% (75/263), respectively. Pregnancy loss included therapeutic abortion in 60 (22.8%), spontaneous abortion in 6 (2.3%), fetal death in 7 (2.7%), and neonatal death in 2 (0.8%). Adverse fetal outcomes included 4 cases (1.5%) with fetal malformation, 56 (21.3%) with premature and 12 (4.6%) with NLE. Obstetrical complications included 35 cases (13.3%) with PIH, 32 (12.2%) with IUGR, 21 (8.0%) with fetal distress. Pregnancy loss in newly diagnosed SLE patients was significantly higher than those in previously diagnosed ones (45.3% vs. 21.8%; P&lt;0.001). In multivariate analysis, hypocomplementemia (OR=3.60, 95%CI 1.30–9.94, P=0.01), hypoproteinemia (OR=3.21, 95%CI 1.23–8.30, P=0.02), antiphospholipid antibodies positivity (OR=8.393, 95%CI 1.73–40.84, P=0.01), anti-DNP antibody positivity (OR=5.64, 95%CI 1.24–28.36, P=0.03), and hypertension (OR=14.597, 95%CI 1.51–141.60, P=0.02) were independent risk factors for APOs. Usage of hydroxychloroquine (OR=0.27, 95%CI 0.11–0.73, P=0.01) during pregnancy was a protective factor for APOs. <h3>Conclusions</h3> The rate of APOs is still high in SLE patients complicated with pregnancy. Pregnancy loss in newly diagnosed SLE patients is significantly higher than those in previously diagnosed ones. Hypocomplementemia, hypoproteinemia, antiphospholipid antibodies positivity, anti-DNP antibody positivity and hypertension are important risk factors for APOs. Usage of hydroxychloroquine during pregnancy is protective. <h3>Disclosure of Interest</h3> None declared
Targeting Histone Deacetylase 6 and the Aggresome Pathway in Acute Lymphoblastic Leukemia Cells.
Authors: Augustin Rodriguez-Gonzalez, James Ch’ng, Alan K. Ikeda, Tara Lin, Bita Bahrami, Ralph Mazitschek, James E. Bradner, Cecilia Fu, Kathleen M. Sakamoto
Journal: Blood (2007)
Pallidal Deep Brain Stimulation for the Treatment of Levodopa-Responsive Juvenile Dystonia and Parkinsonism Secondary to <i>SPG11</i> Mutation
Authors: Adolfo Ramirez-Zamora, Lucy Gee, Youngwon Youn, Damian S. Shin, Julie G. Pilitsis
Journal: JAMA Neurology (2016)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Neurology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Neurology journal
SAP (SH2D1A), the Immunomodulator Deficient in X-Linked Lymphoproliferative Syndrome (XLP), Is Profoundly Decreased in Aplastic Anemia: An Immunologic Link between Constitutional and Acquired Bone Marrow Failure.
Authors: Elena E. Solomou, Valeria Visconte, Federica Gibellini, Neal S. Young
Journal: Blood (2006)
Comparison of Intensive Chemotherapy (CHT), Allogeneic (ALLO) or Autologous (AUTO) Stem Cell Transplantation (SCT) as Post-Remission Treatment for Children with Very High-Risk Acute Lymphoblastic Leukemia (VHR-ALL). Final Results of the PETHEMA ALL-93 Trial.
Authors: Josep-Maria Ribera, Juan-Jose Ortega, Albert Oriol, Pilar Bastida, Carlota Calvo, Jose-María Perez-Hurtado, Maria-Elvira González-Valentin, Vicky Martin-Reina, Antonio Molines, Fernando Ortega-Rivas, Maria-Pilar Queipo, Concepción Rivas, Izaskun Egurbide, Inmaculada Heras, Concepción Poderos, Eva Martínez-Revuelta, Jose-Maria Guinea, Eloy del Potro, Guillermo Deben
Journal: Blood (2005)
PTH-150 Improving Early Diagnosis of Oesophago-Gastric Cancers; A DGH Experience Pre and Post ‘Be Clear On Cancer’ Campaign
Authors: MA Alam, A Sajjad, A Dixon, D Das, M Kasimanickam
Journal: Gut (2016)

<h3>Introduction</h3> Public health England launched a national campaign to raise awareness of oesophago-gastric cancers from 26 Jan – 22 Feb 2015. This was based on seven local projects across England between April – July 2012 which showed 26% statistically significant increase in 2 WW (Two week wait) referrals for suspected upper gastro-intestinal cancers Vs 16% increase in control area, 20% increase in oesophageal cancer diagnoses, 9% increase in overall diagnoses of Upper GI cancers with a small decrease in conversion rate. Our study looked at effect of this campaign in a DGH setting. <h3>Methods</h3> To analyse the impact we collected data of all patients undergoing Upper GI endoscopy following 2 WW referrals from March to August 2015 (post campaign) and compared with the same time previous year 2014 (pre campaign) by identifying through electronic endoscopic reporting (Adam). We looked at indication, age, sex, endoscopic finding and histological confirmation reports. <h3>Results</h3> 524 patients referred in 2015 on 2 WW pathway compared to 329 patients during the same time of year in 2014 resulting in 59% increase in endoscopy load. 50% increase in diagnoses of any upper GI cancer (24 Vs 16) and 7.7% increase in oesophageal cancer (14 Vs 13). Interestingly 10 gastric cancers were identified compared to 3 in 2014. Conversion rate of 5% was seen resulting in diagnoses of any upper GI cancer compared to 4.9% in 2014. 2.7% of referrals for suspected upper GI cancer resulted in diagnoses of oesophageal cancer in 2015 compared to 4% in 2014. <h3>Conclusion</h3> Positive impact of campaign on early diagnoses of upper GI cancer with statistically significant increase in endoscopy burden. There were marginal raise in detection of oesophageal cancer and phenomenal increase in gastric cancer while the conversion rate decreased. <h3>Disclosure of Interest</h3> None Declared
SAT0449 The Relationship between The Articular Surface Projection and Radiologic Laxity of The Trapeziometacarpal Joint
Authors: H.S. Gong
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> The etiology of trapeziometacarpal joint (TMCJ) osteoarthritis is not yet clearly confirmed. Laxity of the TMCJ is considered as one of the causes of osteoarthritis. Previous studies evaluated the relationship between the bony morphology and TMCJ laxity mainly in osteoarthritic TMCJs. It is unclear, however, whether there is such relationship in non-arthritic TMCJ. <h3>Objectives</h3> We aimed to determine whether the articular surface projection was associated with laxity of the TMCJ. <h3>Methods</h3> We measured the trapezial tilt and the first metacarpal base articular slope in radiographs of 108 women without thumb TMCJ osteoarthritis. The mean age was 57 years (range, 32 to 79 years). The trapezial tilt (TT) was defined as the angle formed by the intersection of a tangent to the middle third of the distal trapezial articular surface and a line parallel to the longitudinal axis of the index metacarpal in the posteroanterior radiograph of the trapezium (α in Fig 1A). The metacarpal articular slope (MS) was defined as the angle between the dorsal cortex and the articular surface of the first metacarpal base in a true lateral view of the thumb metacarpal (β in Fig 1B). We evaluated the radiologic laxity of the TMCJ using subluxation ratio (SR) in the TMCJ stress view radiograph (RS (radial subluxation)/AW (articular width) in Fig 1C). We divided the subjects into four subsets according to the TT and MS, and compared the mean SR between the upper and lower quartile groups. <h3>Results</h3> There was a statistically significant difference in the mean SR between those in the upper and lower quartiles of the MS (0.24 vs 0.32, P=0.013). However, there was no difference in the SR with regard to the TT (P=0.189). <h3>Conclusions</h3> This study suggests that a steeper articular slope of the first metacarpal base could be associated with radiologic laxity of the TMCJ. Further longitudinal studies are necessary to determine whether this anatomic difference represent a risk factor for later development of TMCJ osteoarthritis. <h3>Disclosure of Interest</h3> None declared
Pilot/Feasibility Metrics, Real-Time Remote Monitoring, and Inter-Observer Agreement on Veno-Occlusion in a National Multicenter Randomized Controlled Trial of Pediatric Venous Thromboembolism: Findings from the Pilot/Feasibility Phase of the Kids-DOTT Trial
Authors: Neil A Goldenberg, Thomas C. Abshire, Jonathan L Halperin, William R. Hiatt, Craig M. Kessler, John M Kittelson, Marilyn J. Manco-Johnson, Alex Spyropoulos, Phillipe Gabriel Steg, Alexander G.G. Turpie, Sam Schulman
Journal: Blood (2014)
High Resolution Epigenomic Mapping of Myelodysplastic Syndrome Reveals a High Level of Functionally Important Methylation.
Authors: Li Zhou, Joanna Opalinska, Davendra Sohal, Simrit Parmar, Perry Pahanish, Iris Isulfi, Kenny Ye, Maria Figueroa, John Greally, Ari Melnick, Amit Verma
Journal: Blood (2006)
Herpesvirus Viremia and Engraftment Status of Umbilical Cord Blood in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplant
Authors: Ibrahim Al_Harbi, Yvonne Yau, Upton Allen, Tal Schechter, Wendy Lau, Astrid Petrich, Adam Gassas, Elizabeth McDougall, John J Doyle
Journal: Blood (2011)
AB0506 Systemic Lupus Erythematosus: Neuropsychiatric Manifestations
Authors: S. Monov, D. Monova, R. Rashkov, R. Shumnalieva
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by autoantibody production, complement activation and deposition of immune complexes in tissues and organs. According to different authors about 25–79% of the SLE patients have neuropsyhiatric involvement (NPSLE) at same point of the disease course. The latter could be the only and single disease manifestation but often NPSLE is present in patients with active disease. <h3>Objectives</h3> Our objective is to present the results from our study about the neuropsychiatric manifestations in patients with SLE. Based on its results we propose a new set of criteria for NPSLE. The use of these criteria for the last 5 years in Bulgarian patients with SLE proved their high sensitivity and specificity. <h3>Methods</h3> In order to determine the type and incidence of nervous system (NS) damages clinical, laboratory, and instrumental examinations were performed in a total number of 225 patients with SLE for a total period of 9 years. Depending on the specific features of the clinical course the patients were divided into three groups: with clinically manifested NS damages, without clinically manifested NS damages and with incomplete SLE. Patients with rheumatoid arthritis and healthy controls matched for age and gender were used as control groups. <h3>Results</h3> The study showed high percentage (64,44%) of neuropsychiatric manifestations in the SLE patients. Cognitive dysfunctions were found in 49,33% of the SLE patients. According to this set of criteria the NPSLE diagnosis should be made in the presence of at least one indicator from the first group of criteria (seizures, psychosis, cerebrovascular event, lesion of cranial nerves, motor disturbances, quantitative alterations of consciousness) and at least two indicators from the second group of criteria (cognitive dysfunction, headache due to lupus, peripheral neuropathy, MRI changes, EEG changes, ENMG changes, positive aRPA, positive aPL) after excluding other causes than SLE for their occurrence. <h3>Conclusions</h3> The use of the proposed criteria of NPSLE with high specificity and sensitivity is of practical value allowing earlier detection of NS damages and introduction of adequate pathogenic treatment. <h3>Disclosure of Interest</h3> None declared
Review: In adults with diabetes, aspirin does not prevent CV events compared with placebo
Authors: Harvey J. Murff
Journal: Annals of Internal Medicine (2016)

Source Citation Kunutsor SK, Seidu S, Khunti K. Aspirin for primary prevention of cardiovascular and all-cause mortality events in diabetes: updated meta-analysis of randomized controlled trials. Diabet Med. 2016. [Epub ahead of print]. 27086572
P292 Pilot study to assess bronchodilator response during an acute exacerbation of copd using a vibrating mesh nebuliser versus jet nebuliser for bronchodilator delivery
Authors: B Cushen, A Alsaid, A Abdulkareem, RW Costello
Journal: Thorax (2016)

<h3>Introduction</h3> Recovery from COPD exacerbation is associated with increases in respirable lung volume. Accelerating these changes through improved bronchodilator delivery could hasten recovery. <h3>Hypothesis</h3> Vibrating mesh nebuliser (Aerogen® Ultra) results in greater change in lung physiology compared to standard small volume jet nebuliser. <h3>Methods</h3> Patients with an exacerbation of COPD were randomised to receive combined salbutamol 2.5 mg/ipratropium bromide 0.5mg via vibrating mesh (Active group) or standard hospital jet nebuliser (Control) on one occasion between day 2–7 of hospitalisation. Spirometry, body plethysmography and impulse oscillometry were performed pre-bronchodilator and at 1 hour post. Borg breathlessness score was measured. <h3>Results</h3> Thirty-one patients have been recruited to date, 16 to the active group and 15 control group. Mean FEV<sub>1</sub> was 48 ± 18% predicted. Baseline demographics were comparable between groups. Both groups had significant improvements in FEV<sub>1</sub> and Inspiratory Capacity post-bronchodilator, with greater increases in FVC in the active group (0.40 ± 0.39 L vs 0.19 ± 0.19 L, p = 0.06). Significant changes in operating lung volumes and airway impedance were seen in both groups. There was no significant difference in Borg score. <h3>Conclusion</h3> Bronchodilator administration, during a COPD exacerbation, results in significant improvements in spirometry, lung volume and airway impedance. Drug delivery by vibrating mesh nebuliser results in greater absolute increases in FVC. Further studies will assess whether this translates into accelerated exacerbation recovery.
AB0943 Reliability of Musculoskeletal Ultrasound To Detect Elementary Lesions in Juvenile Idiopathic Arthritis
Authors: C. Hernández Díaz, L. Ventura-Ríos, L. De la Cruz Becerra, L. Barzola, A. Rodríguez García, G. Sanchez Bringas, E. Faugier, J. Roth
Journal: Annals of the Rheumatic Diseases (2016)

<h3>Background</h3> Clinical evaluation has limitations to detect inflammation in JIA. Musculoskeletal ultrasonography (MSKUS) is a useful tool to detect inflammation in various arthropathies, but in children has not been validated for detection of elementary lesions such as synovitis [effusion (SE) and synovial hypertrophy (SH)], erosions, tenosynovitis (TNS) and cartilage damage. <h3>Objectives</h3> To evaluate the reliability of MSKUS to detect carpal and metacarpal joint synovitis in patients with JIA. <h3>Methods</h3> Seven patients with JIA diagnose according to ILAR criteria were included; they were evaluated by MSKUS for 5 ultrasonographers to evaluate synovitis, erosions, TNS and cartilage in the carpal joint, 2nd and 3rd metacarpophalangeal joints bilaterally; in 2 rounds in one day. Intra- and interobserver variability was established with Cohen9s kappa, according to Landis and Koch classification. <h3>Results</h3> The mean age of the children was 9 years old; disease duration of 5 years. The inter-observer DS, HS, TNS and erosions agreement was good to excellent (k=.88 0.5889–1.0 95%, p=0.0000) and moderate for cartilage (k=0.43, 95% CI 0.0545 to 0.8964, p=0). The intra-observer variability was good (0.71, IC95% from 0.591 to 0.8498, p=0.0000). <h3>Conclusions</h3> The US is reliable for assessing the presence of synovitis, tenosynovitis, erosion and cartilage in hands, in patients with JIA. <h3>Disclosure of Interest</h3> None declared
PTH-037 The Shock Index: A Novel and Useful Predictor of Mortality and Morbidity in Upper Gastrointestinal Bleeds?
Authors: N Jawad, S Horlick, A Robbins, E Seward
Journal: Gut (2016)

<h3>Introduction</h3> The aim of this study was to evaluate the usefulness of the Shock Index (heart rate/systolic blood pressure), a widely used measure of haemodynamic stability in trauma and sepsis, in triaging patients with suspected upper gastrointestinal (UGI) bleeds. Compliance with assigning Blatchford and Pre-Rockall scores, the current risk assessment scores for UGI bleeds, is poor despite being mandated by national guidelines. We therefore wished to assess whether the Shock Index, a quick and easy measure, was as accurate at triaging these patients in determining the severity of the bleed. <h3>Methods</h3> Data from 46 patients who underwent oesophago-gastro-duodenoscopies (OGD) between January and October 2015 was retrospectively analysed and the Blatchford, Pre-Rockall and Shock Index scores calculated. In our cohort, 19 patients were admitted via A&amp;E and there was only one incidence of variceal bleeding and an additional case of cirrhosis. Sensitivity and specificity were calculated and Fischer's Exact Test was performed to ascertain which of the scores was most correlated with adverse outcome (defined as needing transfusion). The cutoff point for an abnormal Shock index score was defined as &gt;0.7, as used in the 2015 NCEPOD report. <h3>Results</h3> Of the 46 patients reviewed, 17 had adverse outcomes indicating a severe UGI bleed. The Shock Index was raised in 8/17 of these patients (sensitivity 47.1%) whereas the Blatchford score was elevated (&gt;0) in 16/17 (sensitivity 94.1%) and the Pre-Rockall score was raised (&gt;0) in 15/17 (sensitivity 88.4%). However, of the 29 patients without a severe UGI bleed, the Shock index was &lt;0.7 in 16/29 (specificity 55.2%) while 19/29 had a raised Blatchford score in the absence of a severe bleed (specificity 34.2%) and 17/29 had a raised Pre-Rockall (specificity 41.3%). Fischer's Exact Test showed that the Blatchford and Rockall scores were correlated with severe outcomes with p values of 0.0356 and 0.0487 respectively, the Shock Index had a p value of 0.8834 demonstrating a non significant correlation with bleed severity. <h3>Conclusion</h3> The Shock Index, a novel tool to assess the severity of UGI bleeds, lacks the sensitivity of the Blatchford and Pre-Rockall scores but is a better differentiator of those with mild UGI bleeds, as reflected in its greater specificity. The 2015 NCEPOD study demonstrated a sensitivity of 64.2% for the shock index when looking at patients requiring 4 or more units of blood, suggesting that it is better at identifying more serious bleeds. The role of the shock index could be as a useful adjunct to the more widely used Blatchford and Pre-Rockall scores and have a role in stratifying patients in which these scores are raised. <h3>Disclosure of Interest</h3> None Declared
Rational design of protamine nanocapsules as antigen delivery carriers
Authors: José Vicente González-Aramundiz, Elena Presas, Inmaculada Dalmau-Mena, Susana Martínez-Pulgarín, Covadonga Alonso, José M Escribano, María J. Alonso, Noemi Stefánia Csaba
Journal: Journal of Controlled Release (2016)
Hyperglycemia during Neutropenia Was Associated with the Risk of Infection and Organ Dysfunction in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation (HSCT).
Authors: Shigeo Fuji, Sung-Won Kim, Shin-ichiro Mori, Shigemi Kamiya, Takahiro Fukuda, Satoshi Yamazaki, Ryuji Tanosaki, Kensei Tobinai, Yoichi Takaue
Journal: Blood (2006)