tbuckley/cabot-search huggingface dataset:
THU0277 Absence of radiographic progression at two years in a cohort of patients with non- radiographic axial spondyloarthritis treated with TNFA blockers
Authors: J.G. Lopez Velandia, M. Almirall, J. Perez Ruiz, J. Maymό Guarch, M.P. Lisbona, A. Pàmies, I. Silvia, J. Carbonell
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> An inhibitory effect of TNFa blockers on radiographic progression at two years has not been demonstrated until now in patients with Ankylosing Spondylitis. Moreover, in studies evaluating the structural progression of non-radiographic axial Spondylarthritis patients did not receive biological therapy or a small percentage of them did. <h3>Objectives</h3> To assess radiographic progression in the spine and sacroiliac joints at two years in a cohort of patients with non-radiographic axial Spondyloarthritis treated with TNFa blockers. <h3>Methods</h3> After systematic review of clinical registries, nineteen patients with non-radiographic axial Spondyloarthritis were selected for this analysis based on availability of spinal (cervical and lumbar) and anteroposterior pelvic radiographs at baseline and after two years of follow-up with the same treatment with TNFa blocker. Nineteen patients fulfilled ASAS classification criteria for axial Spondyloarthritis but did not fulfil radiological criterion of the modified New York criteria for Ankylosing Spondylitis (bilateral sacroiliitis of at least grade 2 or unilateral grade 3-4). Spinal radiographs were scored by two trained readers (LJ and AM) according to the Stoke Ankylosing Spondylitis Spine Score (mSASSS) system and sacroiliac joints according to the New York criteria scoring system, in a chronological order (at baseline and after two years with the same treatment). <h3>Results</h3> The nineteen patients fulfilled ASAS classification criteria for axial Spondyloarthritis and six had active inflammation demonstrated by MRI. Twelve patients received Adalimumab, two received Infliximab and five received Etanercept. mSASSS score was zero at baseline and after two years of treatment in all patients (none of the patients developed structural damage in spine). There was not radiological progression in sacroiliac joints in none of the patients. None of the nineteen patients fulfilled the modified New York criteria for Ankylosing Spondylitis at two years with TNFa blockers therapy. <h3>Conclusions</h3> None of the patients of our cohort with non-radiographic axial Spondylarthritis showed radiographic progression in the spine or sacroiliac joints at two years of treatment with TNFa blockers. <h3>Disclosure of Interest</h3> None Declared
AB0117 Peptidyl-Arginine Deiminase (PAD) Activity and the Citrullination of Soluble Blood Proteins in Relation with Periodontal Activity, P. Gingivalis and Clinical Activity of Rheumatoid Arthritis Patients. Preliminary Study
Authors: D. Xibille-Friedmann, J.-I. Martinez-Rivera, M. de la Garza-Ramos, J. Rodriguez-Amado, C. BustosRivera-Bahena, M. Sandoval-Rios, J.-L. Montiel-Hernandez
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Although several studies have suggested the association between periodontitis, infection by <i>Porphyromona gingivalis</i> and elevated Rheumatoid Arthritis disease activity, its relationship with oral and plasma peptidyl-arginine deiminase (PAD) activity and citrullination of soluble blood proteins remains still poorly known. <h3>Objectives</h3> To evaluate the relationship between periodontal activity, <i>P. gingivalis</i> infection, PAD activity and clínical disease activity of Rheumatoid Arthritis (RA) patients. <h3>Methods</h3> All RA patients included in the present study fulfilled the ACR 2010 criteria, signed an informed consent form and were followed at the rheumatology clinic for one year. Periodontal evaluation and oral and peripheral blood samples were obtained the same day as the rheumatology evaluation by the periodontal screening recording index (PSR). PAD-activity was performed using a colorimetric assay employing as substrate BAEE (Sigma) and as positive control recombinant human PAD4 (Cayman Chem). Citrullination was evaluated by WB of immunoprecipitated saliva and blood fibrinogen, employing polyclonal anti-citrulline antibody (Millipore). Plasma pro-inflammatory cytokines and aCCP levels were evaluated by ELISA. Descriptive statistics were employed to evaluate differences between groups and Spearman correlation was used to associate them with clinical parameters. <h3>Results</h3> A preliminar analysis was done in 48 RA patients whose mean age (41.2 vs. 43 years), BMI (26.8 vs. 27.2) and time since onset of disease (8.5±10.9 vs. 5.44±3.8) were statistically similar between those with high disease activity (DAS28 &gt;3.4) and low disease activity (DAS28 ≤3.4). In contrast to other studies, high disease activity patients were significant associated with a low index of periodontitis (1.57±1.06; p&lt;0.02), while high disease activity patients were associated with severe periodontitis (3.0±1.23). Otherwise, high disease activity patients showed a mean decrease of 1.5 DAS28 units after one year of follow-up, while low disease activity RA patients showed a lower therapeutic response (change of &lt;0.5 DAS28 units). Evaluation of <i>P. gingivalis</i>, PAD activity, fibronectin citrullination are currently performed <h3>Conclusions</h3> Preliminarly, our results suggest that high RA disease activity is negatively associated with severe periodontitis, although the same patients showed a higher therapeutic response after one year of follow up, in comparison to low disease activity RA patients. <h3>Acknowledgements</h3> This work was supported by a grant from SEP/CONACYT CB-2010 (#155392). <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3922
THU0060 Risk factors of interstitial lung disease in patients with rheumatoid arthritis
Authors: J. Kur-Zalewska, M. Tlustochowicz, W. Tlustochowicz
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Objectives</h3> The aim of the study was to determine risk factors of interstitial lung disease (ILD) in patients with rheumatoid arthritis (RA). <h3>Methods</h3> 111 unselected patients (94 women and 17 men) with RA, as defined by the 1987 ARA criteria, were included in the study. The diagnosis of ILD was based on high resolution computed tomography (HRCT) of the chest. The following risk factors of RA related ILD (RA-ILD) were evaluated: –demographic: age and gender, –smoking status: current, former and cigarette pack-year, –RA related: disease duration, Steinbrocker radiological stage, presence of atlanto-axial subluxation; presence of extra-articular manifestations (vasculitis, Sjögren syndrome, amyloidosis and subcutaneous rheumatoid nodules); activity indices assessed by both patient and rheumatologist (morning stiffness, tender and swollen joint counts, DAS28, VAS-pain, VAS-activity, HAQ, Steinbrocker functional class); laboratory test results (ESR, CRP, Hgb, PLT), serological markers (RF, ACPA, ANA, ENA) –treatment related: methotrexate (MTX) use, duration of MTX use, MTX dose (current, cumulative and yearly; yearly MTX dose was defined as cumulative MTX dose/year of RA duration), prednisone use, cumulative dose of prednisone, other synthetic and biological DMARDs use. <h3>Results</h3> The mean age was 60.7 years. Median duration of RA was 7 years. Abnormalities consistent with ILD were found in 53 patients (47,8%). Univariate analysis revealed significantly increased risk ofRA-ILD in patients with older age (per 5 years: OR 1,41; 95% CI 1,16-1,73; p- 0,001), presence of atlanto-axial subluxation (OR 4,39; 95% CI 1,33-14,46; p- 0,02), higher Steinbrocker functional class (OR 2,96; 95% CI 1,39-6,32; p- 0,01) and higher serum RF level (per 100 IU/ml: OR 1,22; 95% CI 1,05-1,41; p- 0,01). Cyclosporine A use (OR 0,31; 95% CI 0,12-0,79; p- 0,01), infliximab use (OR 0,12; 95% CI 0,01-0,99; p- 0,05) and treatment with higher current (per 5mg/week: OR 0,7; 95% CI 0,57-0,88; p- 0,002), cumulative (per 1000 mg: OR 0,74; 95% CI 0,58-0,95; p- 0,02) and yearly MTX dose (per 100 mg/1 year of RA: OR 0,74; 95% CI 0,62-0,88; p- 0,001) were associated with a significantly lower ILD risk. Multivariate analysis showed following risk factors ofRA-ILD: age, serum RF level and yearly MTX dose. The risk of RA-ILD significantly increased with older age (per 5 years: OR 1,35; 95% CI 1,001-1,68; p- 0,007) and higher serum RF level (per 100 IU/ml: OR 1,16; 95% CI 1,001-1,36; p- 0,05), while higher yearly MTX dose significantly decreased the risk of RA-ILD (per 100 mg/1 year of RA: OR 0,74; 95% CI 0,61-0,9; p- 0,003). <h3>Conclusions</h3> The independent risk factors of ILD in patients with RA were older age, higher serum RF level and treatment with lower MTX dose. <h3>Disclosure of Interest</h3> None Declared
Abstract 98: Differential methylation of promoters in ductal adenocarcinoma and cancers of the ampulla vateri of the pancreas
Authors: Christian Pilarsky, Katja Biewusch, Marie Heyne, Robert Grützmann, Hans Detlev Saeger
Journal: Cancer Research (2011)

Abstract Background: Prognosis for patients with pancreatic carcinoma (PDAC) remains poor. Despite of increasing knowledge about the molecular basis of PDAC neither a specific marker for early diagnosis nor a target protein for a new therapeutic approach have been identified so far. Determination of DNA methylation events is a promising technology for the early detection and classification of cancer. We were therefore interested to elucidate the significance of DNA methylation to distinct between ductal adenocarcinoma and cancers of the ampulla vateri (AVT) of the pancreas. Methods: DNA isolation using the Qiamp mini kit and modification using the Zymo EZ DNA Methylation-Gold system was performed. Primers for methylation specific PCR (MSP) for RELN, ADAMTS8, SFRP1, BNIP3, ID4 and TFPI2 were selected from the literature and tested for their performance on bisulfite modified fully methylated human DNA. After successfully establishing the assays, DNA samples isolated from formalin fixed and paraffin embedded tissue from patients with diagnosed ductal adenocarcinoma (n = 14) and tumors of the ampulla vateri (n=7) were investigated. MSP was performed and the amount of produced fragment was scored semiquantitatively using agarose gelelectrophoresis. Results: MSP analysis of the bisulfite modified DNA showed methylation differences in RELN (PDAC: 63%, AVT: 37%), ADAMTS8 (PDAC: 37%, AVT: 14%), BNIP3 (PDAC: 85%, AVT: 50%), SFRP1 (PDAC: 84%, AVT: 100%) and ID4 (PDAC: 93%, AVT: 62,5). Interestingly, for TFPI2 both tumors types showed nearly the same incidence of methylation events (PDAC: 86%; AVT: 87%). Conclusion: Detection of DNA methylation is able to indentify differences between tumors of the pancreas. This might resemble crucial changes during tumor development, which are also reflected in gene expression and histopathologic appearance. For the establishment of a methylation-based discrimination of tumors further samples and promoters have to be tested. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 98. doi:10.1158/1538-7445.AM2011-98
DISPARITIES IN LIPID MANAGEMENT IN PATIENTS WITH PERIPHERAL ARTERY DISEASE VERSUS CORONARY ARTERY DISEASE: COMPARISON BETWEEN ATP III AND 2013 AHA/ACC GUIDELINES
Authors: Vinodh Jeevanantham, Suresh Sharma, Rashmi Thapa, Taylor Myers, James Vacek, Buddhadeb Dawn, Kamal Gupta
Journal: Journal of the American College of Cardiology (2015)
SAT0174 CCR5DELTA32 is associated with class IV nephritis in systemic lupus erythematosus
Authors: J.S. Schauren, T.D. Veit, O.A. Monticielo, R.M. Xavier, J.C.T. Brenol, J.A.B. Chies
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Systemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease that involves many organs and systems. CCR5 is an important chemokine receptor involved in inflammation. It is mainly expressed on the surface of cells that participate in the inflammatory process, such as lymphocytes and activated Th1 memory cells, monocytes, macrophages, dendritic cells and neutrophils. The <i>CCR5</i> gene is located on chromosome 3p21.3-p24, and the CCR5Delta32 allelic variant generates a truncated protein that does not reach the cell surface, altering the response of these cells during inflammation. <h3>Objectives</h3> To analyze the allelic and genotypic frequencies of the CCR5Delta32 polymorphism in systemic lupus erythematosus (SLE) patients from southern Brazil and to investigate a possible association of this allele variant with SLE susceptibility and clinical outcomes. <h3>Methods</h3> We analyzed 367 SLE patients and 360 controls by PCR genotyping. <h3>Results</h3> No association of this variant with susceptibility to SLE was observed. However, we observed that a majority of SLE patients diagnosed with nephritis that carried the CCR5Delta32 allele had been classified as class IV (67%). Patients carrying the CCR5Delta32 allele presented an odds ratio of 5.37 (1.77 – 15.25) for the development of class IV nephritis in relation to non-carrier patients. After stratifying by ethnic origin, African-derived carriers presented an odds ratio of 16.00 (1.87-188.93) in relation to non-carriers from the same ethnicity, whereas all European-derived patient carriers of the CCR5Δ32 allele who had biopsy proven nephritis had been classified as class IV. A multivariate analysis controlling the presence of the CCR5Delta32 allele, anti-DNAds antibodies, ethnicity, sex and age at diagnosis of SLE yielded a 2.96 times greater relative risk for a patient with the CCR5Delta32 allele to develop class IV nephritis in our cohort. <h3>Conclusions</h3> Our data suggest that the CCR5Delta32 allele is an important modifier in SLE and could be considered a susceptibility factor to class IV nephritis, and that in African-derived, perhaps due to higher genetic susceptibility, this factor is more evident. <h3>References</h3> Martens H.A., et al. Lack of association of C-C chemokine receptor 5 Δ32 deletion status with rheumatoid arthritis, systemic lupus erythematosus, lupus nephritis, and disease severity. J Rheumatol. 2010 Nov;37(11):2226-31. Martens H.A., et al. Role of CCR5 Delta32 bp deletion in RA and SLE. Autoimmunity. 2009 May;42(4):260-2. Mamtani M., et al. CCL3L1 gene-containing segmental duplications and polymorphisms in CCR5 affect risk of systemic lupus erythaematosus. Ann Rheum Dis, 2008;67:1076-83. Aguilar F., et al. Chemokine receptor CCR2/CCR5 polymorphism in Spanish patients with systemic lupus erythematosus. J Rheumatol. 2003 Aug;30(8):1770-4. <h3>Disclosure of Interest</h3> None Declared
Cancer Inceidence in Seattle Women's Health Trial Participants by Group and Time Since Randomization
Authors: Maureen M. Henderson, Emily White, Robert S. Thompson
Journal: JNCI Journal of the National Cancer Institute (1991)

Journal Article Cancer Inceidence in Seattle Women's Health Trial Participants by Group and Time Since Randomization Get access MAUREEN M. HENDERSON, MAUREEN M. HENDERSON Search for other works by this author on: Oxford Academic PubMed Google Scholar EMILY WHITE, EMILY WHITE Search for other works by this author on: Oxford Academic PubMed Google Scholar ROBERT S. THOMPSON ROBERT S. THOMPSON Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 83, Issue 17, 4 September 1991, Pages 1260–1261, https://doi.org/10.1093/jnci/83.17.1260 Published: 04 September 1991
Abstract LB-46: Advocacy &amp; Action
Authors: Katherine E. McIntyre
Journal: Cancer Research (2012)

Abstract These powerful core statements communicate our purpose and express the heart and soul of all we do, and why we do it. Mission Rooted in God's love; we treat illness and promote wellness for all people. Vision Our vision is to set the standards of excellence in delivery of health care throughout the regions we serve. Values The following values are represented by the six brush strokes preceding our name in the logo. They serve as a reminder to ourselves and our community that our values precede-literally and figuratively-everything we do. - Compassion: Showing empathy and concern for everyone and responding with kindness, and sensitivity. - Quality: Optimizing talents, skills and abilities to achieve excellence in meeting and exceeding our patients’ expectations - Integrity: Adhering without compromise to high moral principles of honest, loyalty, sincerity and fairness - Courtesy: Demonstrating polite, cooperative and respectful behavior; showing consideration and care for each person - Accountability: Using material good wisely; being conscious of the environment; being accountable for prudent use of our talents and financial resources. -Team Work: Working together to accomplish task and goals; recognizing the interdependence of one another and cache person's unique gifts. Navigators Three patient navigators are employed at Lewis Cancer &amp; Research Pavilion. The LCRP also employs patient resource navigators (social workers). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr LB-46. doi:1538-7445.AM2012-LB-46
Abstract 114: Study of the high-grade ovarian cancer precursors in the oviduct
Authors: In Young Hwang, Ju Yuan, Gang Ning, Seok Wei Tay, Yusuke Yamamoto, Francesca Menghi, Edison Liu, Christopher P. Crum, Frank McKeon, Wa Xian
Journal: Cancer Research (2012)

Abstract The discovery that many high-grade ovarian cancers originate in the oviduct has generated a paradigm shift in the field of ovarian cancer. The description of new entities in the oviduct that signify early phases of ovarian carcinogenesis, including both serous tubal intraepithelial carcinomas and their precursors the p53 signatures, has provided a tangible sequence of events leading to malignancy that can be linked to DNA damage and p53 mutations. However, it has become clear that other pathway disturbances also play a critical role in the early development of ovarian cancer. We hypothesize that molecular alterations present in morphologically normal oviductal epithelium from ovarian cancer patients reflect the earliest events in ovarian carcinogenesis and may be markers of increased cancer risk as well as targets for risk reduction. Whole-genome transcriptome analysis of laser microdissected oviductal epithelium from histologically normal ovarian cancer patients and controls was performed. We identified a set of aberrantly expressed genes in the oviductal epithelium from women who developed high-grade ovarian cancer and demonstrated some of these genes are also abnormally expressed in the ovarian cancers due to the genomic alterations. We further examined the function of these genes using three-dimensional cell culture system and mouse models. Our work demonstrates the synergistic effects of defective p53 pathway and other newly found pathways in driving early steps of ovarian cancer development. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 114. doi:1538-7445.AM2012-114
Preparing to be punched: Prediction may not always require inference of intentions
Authors: Helene Kreysa
Journal: Behavioral and Brain Sciences (2013)

Abstract Pickering &amp; Garrod's (P&amp;G's) framework assumes an efference copy based on the interlocutor's intentions. Yet, elaborate attribution of intentions may not always be necessary for online prediction. Instead, contextual cues such as speaker gaze can provide similar information with a lower demand on processing resources.
Intrathoracic Stomach Causing a Pitfall on Thyroid Imaging
Authors: RECEP BEKİŞ, HATİCE DURAK
Journal: Clinical Nuclear Medicine (1998)

A 35-year-old woman underwent thoracic esophagectomy because of esophageal cancer, during which the stomach had been pulled up through the esophageal bed. She had also undergone subtotal thyroidectomy 5 years earlier because of nodular goiter. Focal uptake was seen at the level of the incisura sternalis on the control Tc-99m pertechnetate thyroid image, indicating ectopic thyroid tissue. On thoracic images taken after she drank water to exclude salivary activity in the esophagus, the uptake at the level of the incisura sternalis was shown to be related to the intrathoracic stomach. The surgery resulting in intrathoracic stomach may cause a false appearance of ectopic or retrosternal thyroid tissue.
Why the National Institutes of Health should create an institute of positive biology
Authors: Colin Farrelly
Journal: Journal of the Royal Society of Medicine (2012)

The National Institutes of Health (NIH) is the largest source of funding for medical research in the world. With an annual budget currently over $31 billion, the NIH awards more than 50,000 competitive grants to thousands of researchers working in the USA and around the world. The NIH is composed of 27 distinct institutes and centers, many of which are institutes for specific diseases, such as the National Cancer Institute (NCI), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Allergy and Infectious Diseases (NIAID) and the National Institute of Neurological Disorders and Stroke (NINDS), just to name a few.