tbuckley/cabot-search huggingface dataset:
Combination chemotherapy with docetaxel and gemcitabine in patients with metastatic or locally advanced pancreatic carcinoma: results of a multicenter phase II study
Authors: J. Fahlke, K. Ridwelski, C. Schmidt, P. Stübs, M. Weber, K. Eichelmann, E. Kettner, A. Hribaschek, H. Lippert
Journal: Journal of Clinical Oncology (2004)

4101 Background: Single-agent gemcitabine for palliative chemotherapy in pancreatic carcinoma results in low tumor response rates and minor prolonged survival. Results may be improved by a combination of gemcitabine with other cytotoxic agents. This multicenter study investigated the efficacy of a combination of gemcitabine (G) and docetaxel (D) for locally advanced or metastatic pancreatic cancer (LAMPC) in terms of response rate and survival. Methods: Of 55 enrolled patients (pts) with LAMPC: 24 were female, the median age was 61 years (range: 39–72), 33 had primary metastatic disease, 17 had primary locally advanced inoperable disease, and 5 had relapsed or developed metastases post surgery. Pts received optimal doses of both drugs from a previous dose-finding study: weekly G 1000 mg/m2and D 35 mg/m2on Days 1, 8, and 15, followed by 7 days rest. Cycles were repeated every 4 weeks (Day 29). Tumor response was assessed by ultrasonography (and computed tomography, if necessary), chest X-ray, tumor markers, and clinical examination. Quality of life (QoL) was recorded with the EORTC QoL questionaire, QLQ-C 30. Results: A total of 195 therapy cycles were administered to 55 pts (median, 3; range: 1–11) and an overall response of 20% was achieved: 1 pt (1.8%) had a complete response, 10 (18.2%) had partial responses, 28 (50.9%) had stable disease, and 14 (25.5%) had disease progression. One pt was untreated, while another refused therapy and was excluded from the study. With 4 pts alive, median survival is 8.1 months and 1-year survival, 29% (16 of 55 pts). Toxicity was low and QoL was acceptable. Conclusions: Docetaxel plus gemcitabine is well tolerated and markedly increases response rate in pts with metastatic pancreatic carcinoma. Current evidence supports testing this chemotherapy protocol in a phase-III setting. No significant financial relationships to disclose.
246 LABILE IRON POOL (LIP) ASSOCIATED TO ACTIVATED MACROPHAGES PLAYS A CENTRAL ROLE IN IRON MEDIATED TOXICITY IN ACLF WITH MULTI-ORGAN FAILURE
Authors: J.S. Maras, H.C. Harsha, N.T. Pati, C.K. Kumar, D.K. Kumar, A. Pandey, S.K. Sarin
Journal: Journal of Hepatology (2012)
A comparative analysis of plastic biliary stenting on demand or every 3 months for irretrievable bile duct stone disease
Authors: Yucel Ustundag, Ulku Saritas
Journal: Endoscopy (2014)

We read with interest the article by Di Giorgio et al. titled “Endoscopic plastic stenting for bile duct stones: stent changing on demand or every 3 months. A prospective comparison study” [1]. In this article, the authors studied the rate of stone clearance and cholangitis in 78 patients with irretrievable stones in the common bile duct treated with endoscopic plastic biliary stenting. The primary aim of this study was to compare the rate of cholangitis in patients for whom two different strategies were applied for biliary plastic endoprosthesis implantation. The authors stated that the group of patients with stent changing every 3 months (group A) had a significantly lower cholangitis rate than the patient group with stent changing on demand (group B) (29 % vs. 36 %, P = 0.03). Nevertheless, the authors found similar rates of stone clearance in patients with stent changing on demand as compared with every 3 months (61.5 % vs. 53.8 %, respectively, P > 0.05).
AB1103 Multidisciplinary rehabilitation in chronic lumbar pain: Long-term effect on work status
Authors: M. Norberg, C. Schindler
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Chronic lumbar pain rests an expensive condition including direct and indirect costs. The most costly patients are them with a long sick-leave for more than 6 months, and with increasing time it is more and more difficult it is to bring them back to work. In this situation, several treatment possibilities exist, but with long standing work absences a multidisciplinary group program has the best possibilities to function. When treating on the deconditioning situation there should be an increase of the return to work. <h3>Objectives</h3> The aim of this study is to analyze the return to work, considering the psychological changes and the work status. <h3>Methods</h3> We have studied the results of 300 of our patients that have accomplished a multi-disciplinary program and that have been followed over 24 months. The program contained physical training, occupational work hardening the hole in a cogntivo-comportemental approach. We have analyzed the relationship between to the work capacity and its correlation with different pain questionnaires (VAS, Oswestry; Roland –Morris, Dallas pain questionnaire; SF-36, HADS and FABQ). <h3>Results</h3> The first and most important parameter was the work capacity, comparing it before inclusion and at 24 months after completing the program. There was a clear increase, from 48% to 80.4% (p&lt;0.01). Associated with this work capacity, we saw a real decrease in apprehensions and pain functioning. There were a positive relationship between on pain questionnaires, with an Oswestry going from 36 to 14% at 24 months. The return to work was not associated to an increase in physical performances but in an increase in apprehension. <h3>Conclusions</h3> In chronic low back patients, with repeated work absences, a multidisciplinary rehabilitation program, with 72% that returned to work, with a global work capacity of 80.4%. The correlation was presented on the psychological part, with less apprehension and also increased global SF 36 values. Then an increase in body confidence rests the important factor in these functional programs. <h3>Disclosure of Interest</h3> None Declared
Abstract 1425: Dasatinib reverses the phenotype of cancer associated fibroblasts (CAFs) to a normal fibroblast (NAF) like phenotype
Authors: Jens O. Schmid, Silke Haubeiss, Thomas E. Mürdter, Godehard Friedel, Heiko van der Kuip, Walter E. Aulitzky
Journal: Cancer Research (2010)

Abstract Cancer associated fibroblasts (CAFs) show a molecular and functional phenotype that is different from their normal counterparts (normal fibroblasts, NAFs). It is a well established phenomenon that these modified and activated fibroblasts possess permissive and promoting properties for epithelial tumor cells and therefore play a central role in tumor progression, metastasis, and probably also in sensitivity to antitumor agents. We asked whether CAFs could be reverted back pharmacologically to normal homeostasis by inhibiting PDGFR signalling. We therefore evaluated the efficacy of the FDA approved PDGFR inhibitor Dasatinib on proliferation and gene expression profile of CAF strains isolated from different lung carcinoma specimens. Dasatinib significantly reduced proliferation without inducing cell death in all 40 CAF strains investigated. Genome-wide microarray analysis of 9 CAF strains cultivated in presence or absence of Dasatinib identified 491 genes whose expression was significantly changed at least twofold. 104 of these encoded cell cycle related proteins with a great majority of 97 being down-regulated by Dasatinib. To determine the relevance of the differentially regulated genes in Dasatinib treated cells, we compared the Dasatinib expression signature to the previously described signatures of NAFs and CAFs derived from breast cancer patients (Sadlanova et al., 2008). Importantly, 102 of the 491 genes regulated by Dasatinib were also shown to be differentially expressed in CAFs versus NAFs. The expression of 72 of the genes we identified as down-regulated by Dasatinib was also reduced in NAFs compared to CAFs (p&amp;lt;0.0001 in Fisher's exact analysis). In addition, 30 genes identified as up-regulated by Dasatinib were also found to be elevated in NAFs compared to CAFs (p&amp;lt;0.0001 in Fisher's exact analysis). In summary, our data suggest that Dasatinib may reverse the cancer-activated phenotype of CAFs to a normal fibroblast like phenotype. Dasatinib treatment may therefore also reverse the tumor-promoting properties of CAFs. Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 1425.
Gene Therapy Centers Poised to Proliferate
Authors: E. Blume
Journal: JNCI Journal of the National Cancer Institute (1994)

Journal Article Gene Therapy Centers Poised to Proliferate Get access Elaine Blume Elaine Blume Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 86, Issue 2, 19 January 1994, Pages 80–81, https://doi.org/10.1093/jnci/86.2.80 Published: 19 January 1994
GMC drops cases against doctors who worked at Stafford Hospital
Authors: C. Dyer
Journal: BMJ (2013)

The General Medical Council has dropped cases against four doctors who were in management jobs at Mid Staffordshire NHS Foundation Trust between 2005 and 2009 when inquiries found that patients received “appalling” care and there were hundreds of excess deaths.

The GMC investigated four doctors who held management positions at Stafford Hospital—John Gibson, Valerie Suarez, David Durrans, and Diarmuid Mulherin—and interviewed 26 witnesses. But the regulator has accepted a barrister’s advice that the prospect of proving that their fitness to practise was impaired through misconduct or deficient professional performance was “almost nil.”

Tom Kark QC, who was leading counsel to the public inquiry into failings at the trust, advised the GMC, “The overwhelming preponderance of [witness] evidence is supportive of the defendant doctors. It provides a picture of …
Diffuse replacement of pancreatic parenchyma by intraductal papillary mucinous neoplasm
Authors: Stuart Amateau, Martine McManus, Barish Edil
Journal: Endoscopy (2013)

A 63-year-old insulin-dependent diabetic woman presented to our multidisciplinary group for evaluation and management of multifocal cystic lesions of the pancreas found incidentally by computed tomography during an evaluation of diverticulitis. Initial assessment included endoscopic ultrasound (EUS) with fine-needle aspiration (FNA) by curved linear array echoendoscope. Near-total replacement of the pancreatic parenchyma by innumerable cysts of various size and character was demonstrated, involving all regions of the pancreas ([Fig. 1]; [Video 1]). Several cysts exhibited features that gave cause for concern, including size well over 30 mm, thickened walls, and thickened septations, as well as round, mobile solid structures suggestive of mucin balls ([Fig. 2 a]). Moreover, the main pancreatic duct appeared to communicate with the cysts in the regions of the head and neck ([Video 1]). The minimally spared parenchyma was heterogeneous without lobularity. The major vessels of the abdomen were unremarkable and without abnormality, nor was there evidence of other regional disease or lymphadenopathy. FNA was performed to recover fluid contents from a larger cystic component, and a second pass was performed to confirm the mobility and benign nature of a suspected mucin ball ([Fig. 2 b]).
Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest
Authors: Peter J. Kudenchuk, Siobhan P. Brown, Mohamud Daya, Thomas Rea, Graham Nichol, Laurie J. Morrison, Brian Leroux, Christian Vaillancourt, Lynn Wittwer, Clifton W. Callaway, James Christenson, Debra Egan, Joseph P. Ornato, Myron L. Weisfeldt, Ian G. Stiell, Ahamed H. Idris, Tom P. Aufderheide, James V. Dunford, M. Riccardo Colella, Gary M. Vilke, Ashley M. Brienza, Patrice Desvigne-Nickens, Pamela C. Gray, Randal Gray, Norman Seals, Ron Straight, Paul Dorian
Journal: New England Journal of Medicine (2016)

Antiarrhythmic drugs are used commonly in out-of-hospital cardiac arrest for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, but without proven survival benefit.
P352 THE NATURAL HISTORY OF AUTOIMMUNE HEPATITIS (AIH) PRESENTING WITH JAUNDICE
Authors: O.J. Froud, V. Panayi, L. Vine, P. Laurent, K. Woolson, J.G. Hunter, R.G. Madden, C. Miller, B. Stableforth, I.A. Murray, J. Palmer, N. Harris, J. Mathew, H.R. Dalton
Journal: Journal of Hepatology (2014)
Abstract 132: MicroRNA expression profiling in tumorigenic prostate cancer cells and tumor suppressive functions of let-7
Authors: Can Liu, Kevin Kelnar, Alexander Vlassov, David Brown, Dean Tang
Journal: Cancer Research (2012)

Abstract Most human tumors contain a small population of cells with stem cell properties, called cancer stem cells (CSCs), which are believed to be responsible for tumor initiation, metastasis, resistance to clinical therapy and relapse. It's crucial to understand the regulatory mechanisms unique to CSCs, so that we may design CSC-specific therapeutics. Recent discoveries of microRNA (miRNA) have provided a new avenue in understanding the regulatory mechanisms of cancer. In our previous studies, we have showed miR-34a under-expression in prostate CSC populations, and its critical role in negatively regulating prostate tumor development and metastasis. However, detailed profiling process was not presented due to space limit. Here, we presented the detailed miRNA expression profiling process and results, together with functional studies of let-7. By quantitative RT-PCR, we dicovered miRNA expressions profiles specific to the prostate cancer (PCa) stem/progenitor populations, i.e., CD44, CD133, α2β1 and side population from thee prostate xenograft models (LAPC9, LAPC4, and Du145). Functional annotation of let-7, one of the commonly under-expressed miRNAs in PCa stem/progenitor populations, showed that over-expression of let-7 inhibited proliferation and clonal expansion of prostate cancer cells in vitro. In addition, over-expression of let-7 by a lentiviral vector suppressed tumor development in mice. To further understand how these miRNAs are differentially expressed in the stem/progenitor population of PCa cells, we took miR-34a as an example, and explored p53 and c-Myc regulation in the CD44+ and CD44- populations, but failed to draw a connection. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 132. doi:1538-7445.AM2012-132
Mutations of the Cystic Fibrosis Gene in Patients with Chronic Pancreatitis
Authors: Nicholas Sharer, Martin Schwarz, Geraldine Malone, Andrea Howarth, John Painter, Maurice Super, Joan Braganza
Journal: New England Journal of Medicine (1998)

The pancreatic lesions of cystic fibrosis develop in utero and closely resemble those of chronic pancreatitis. Therefore, we hypothesized that mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene may be more common than expected among patients with chronic pancreatitis.We studied 134 consecutive patients with chronic pancreatitis (alcohol-related disease in 71, hyperparathyroidism in 2, hypertriglyceridemia in 1, and idiopathic disease in 60). We examined DNA for 22 mutations of the CFTR gene that together account for 95 percent of all mutations in patients with cystic fibrosis in the northwest of England. We also determined the length of the noncoding sequence of thymidines in intron 8, since the shorter the sequence, the lower the proportion of normal CFTR messenger RNA.The 94 male and 40 female patients ranged in age from 16 to 86 years. None had a mutation on both copies of the CFTR gene. Eighteen patients (13.4 percent), including 12 without alcoholism, had a CFTR mutation on one chromosome, as compared with a frequency of 5.3 percent among 600 local unrelated partners of persons with a family history of cystic fibrosis (P<0.001). A total of 10.4 percent of the patients had the 5T allele in intron 8 (14 of 134), which is twice the expected frequency (P=0.008). Four patients were heterozygous for both a CFTR mutation and the 5T allele. Patients with a CFTR mutation were younger than those with no mutations (P=0.03). None had the combination of sinopulmonary disease, high sweat electrolyte concentrations, and low nasal potential-difference values that are diagnostic of cystic fibrosis.Mutations of the CFTR gene and the 5T genotype are associated with chronic pancreatitis.
Mammographic Features and Breast Cancer Risk: Effects With Time, Age, and Menopause Status
Authors: C. Byrne, C. Schairer, J. Wolfe, N. Parekh, M. Salane, L. A. Brinton, R. Hoover, R. Haile
Journal: JNCI Journal of the National Cancer Institute (1995)

Journal Article Mammographic Features and Breast Cancer Risk: Effects With Time, Age, and Menopause Status Get access Celia Byrne, Celia Byrne Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer InstituteBethesda, MD Correspondence to present address : Celia Byrne, Ph.D., Channing Laboratory, 180 Longwood Ave., Boston, MA 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar Catherine Schairer, Catherine Schairer Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer InstituteBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar John Wolfe, John Wolfe J. Wolfe (deceased September 1993), Department of Radiology, Hutzel Hospital Search for other works by this author on: Oxford Academic PubMed Google Scholar Navin Parekh, Navin Parekh Department of Radiology, Hutzel HospitalDetroit, MI Search for other works by this author on: Oxford Academic PubMed Google Scholar Martine Salane, Martine Salane Department of Radiology, Hutzel HospitalDetroit, MI Search for other works by this author on: Oxford Academic PubMed Google Scholar Louise A. Brinton, Louise A. Brinton Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer InstituteBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Hoover, Robert Hoover Environmental Epidemiology Branch, Division of Cancer Etiology, National Cancer InstituteBethesda, MD Search for other works by this author on: Oxford Academic PubMed Google Scholar Robert Haile Robert Haile Department of Epidemiology. University of CaliforniaLos Angeles , School of Public Health Search for other works by this author on: Oxford Academic PubMed Google Scholar JNCI: Journal of the National Cancer Institute, Volume 87, Issue 21, 1 November 1995, Pages 1622–1629, https://doi.org/10.1093/jnci/87.21.1622 Published: 01 November 1995 Article history Received: 10 May 1995 Revision received: 08 August 1995 Accepted: 16 August 1995 Published: 01 November 1995
The Relationship between Epicardial Adipose Tissue and ST-segment Resolution in Patients with Acute ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Authors: Ertuğrul Zencirci, Aycan Esen Zencirci, Aleks Değirmencioğlu, Gültekin Karakuş, Sabahattin Gündüz, Aysun Erdem, Kıvılcım Özden, Yalçın Velibey, Metin Çağdaş, Ahmet Ekmekçi, Hatice Betül Erer, Seden Çelik, Ahmet Akyol
Journal: Journal of the American College of Cardiology (2013)
P251 Flow cytometric detection of intracellular activation markers of pulmonary cells during acute lung injury
Authors: A. C. Waite, K. P. O'Dea, M. R. Wilson, M. Takata
Journal: Thorax (2010)

<h3>Background</h3> Activation of intracellular signalling cascades such as mitogen-activated protein (MAP) kinase pathways has been implicated in various animal models of acute lung injury. However, such data rely almost exclusively on measurements within whole lung homogenate samples, so little information is available regarding cell type specific processes. In order to address this, we have developed a flow cytometric technique to identify discrete pulmonary cell populations and examine their early activation in terms of phosphorylation of intracellular MAPkinase pathway intermediates (ERK, p38 and its downstream target MK2). <h3>Methods</h3> Anaesthetised C57BL6 mice were given an intratracheal 20 μg dose of lipopolysaccharide (LPS). Mice were sacrificed at various time points, their lungs were removed, immersed in a buffer to fix and permeabilise cells, and a single cell suspension was produced by mechanical disruption. After incubation at 37°C the cell suspension was washed and centrifuged. Samples were stained at room temperature in the dark with antibodies to identify alveolar macrophages (AM) and epithelial cells (AEC), and to measure the intracellular levels of active phosphorylated forms of ERK, p38 and MK2. Finally the cells were washed and resuspended for flow cytometric analysis. <h3>Results</h3> AM showed a rapid increase in levels of phosphorylated MK2 (see Abstract P251 Figure 1) as well as p38 and ERK on stimulation by intraalveolar LPS. As MK2 showed the most robust response, we determined its phosphorylation in AEC. Those AEC expressing low levels of surface ICAM-1 (likely type II pneumocytes) showed a pattern of increased MK-2 phosphorylation, while ICAM-1 high expressing AEC (type I pneumocytes) did not show a clear response to LPS stimulation. <h3>Conclusion</h3> We have developed a method of investigating activation of individual cells within the lung using flow cytometry, in terms of intracellular MAPkinase phosphorylation. Our data show that AM are rapidly activated upon stimulation by intraalveolar LPS, whereas AEC show signs of delayed activation with type II pneumocytes more responsive than type I cells. Applying this technique to other models, in which alternative cell types and/or pathways may be involved, will enhance our understanding of cellular activation and interactions during acute lung injury.
SHORT AND LONG TERM PROGNOSTIC VALUE OF 256-SLICE CORONARY CT ANGIOGRAPHY IN EMERGENCY DEPARTMENT PATIENTS WITH ACUTE CHEST PAIN
Authors: Ronen Rubinshtein, Yuval Shenkar, Tamar Gaspar, Basheer Karkabi, Salim Halabi, Sharbel Hashoul, Nathan Peled, David Halon
Journal: Journal of the American College of Cardiology (2015)
DURABILITY OF TRANSCATHETER BALLOON-EXPANDABLE AORTIC VALVE: RELATION WITH FRAME DEPLOYMENT ASSESSED WITH MULTIDETECTOR COMPUTED TOMOGRAPHY STUDY
Authors: Frank Van Der Kley, Spiros Katsanos, Philippe Van Rosendael, Vasileios Kamperidis, Jeroen Bax, Martin Schalij, Nina Ajmone Marsan, Victoria Delgado
Journal: Journal of the American College of Cardiology (2015)