tbuckley/cabot-search huggingface dataset:
TCTAP A-152 Impact of Final Kissing Balloon Inflation After Simple Stent Implantation for the Treatment of Non-left Main True Coronary Bifurcation Lesions in Patients with Acute Coronary Syndrome
Authors: Tae-Hoon Kim, Hyun Jong Lee, Ho-Jun Jang, Je Sang Kim, Jin Sik Park, Rak Kyeong Choi, Young Jin Choi, Won-Heum Shim, Young Moo Ro, Cheol Woong Yu, Sung Woo Kwon
Journal: Journal of the American College of Cardiology (2014)
PREDICTION OF FLUOROSCOPY ANGULATION AND CORONARY SINUS LOCATION BY COMPUTED TOMOGRAPHY IN THE CONTEXT OF TRANSCATHETER MITRAL VALVE IMPLANTATION
Authors: Philipp Blanke, Danny Dvir, Jian Ye, Anson Cheung, Robert Boone, David Wood, Pascal Thériault Lauzier, Nicolo Piazza, John Webb, Jonathan Leipsic
Journal: Journal of the American College of Cardiology (2015)
Solitary Breast Metastasis From Recurrent Gallbladder Carcinoma Simulating a Second Primary on 18F-FDG PET/CT
Authors: Bangkim Chandra Khangembam, Punit Sharma, Niraj Naswa, Manas Kumar Sahoo, Rakesh Kumar
Journal: Clinical Nuclear Medicine (2013)

Gallbladder carcinoma is characterized by poor prognosis. It spreads by direct, lymphatic, vascular, neural, intraperitoneal, and intraductal routes. The most commonly involved organ is the liver followed by regional lymph nodes. Extra-abdominal metastases are comparatively rare. We present a case of solitary breast metastasis from recurrent gallbladder carcinoma mimicking a primary breast cancer in (18)F-FDG PET/CT.
AB0632 Paraneoplastic Myositis: the Features of Debut, Clinic Tendency, and Responsiveness to Steroid Therapy
Authors: O. Antelava, A. Khitrov, N. Chichassova, E. Nasonov, A. Khelkovskaya-Sergeeva
Journal: Annals of the Rheumatic Diseases (2014)

<h3>Background</h3> Similarity of muscle and skin symptoms during idiopathic polymyositis/dermatomyositis (DM/PM) and paraneoplasic myositis (PNM) makes clear the clinical tendencies of PNM. <h3>Objectives</h3> To determine the clinical tendencies of PNM. <h3>Methods</h3> We investigated 139 patients with PM/DM and 22 patients with PNM (4 males, 18 females). Laboratory investigation included definition of liver ferments, erythrocyte sedimentation rate (ESR), antibodies to Jo-1, creatinkinase (CK). The manual muscle testing (MMT) was performed according to IMACS recommendations. <h3>Results</h3> Duration of PNM was 8,68±11,6 months at the moment of investigation. Duration of investigation was 36,5±21,2 months. The mean age of patients with debut of PNM was 55,9 years. The tumor was diagnosed in 10 patients before the clinical manifestations of myositis, and in 12 (54,5%) patients after manifestation. Tumor localization was in ovaries (10 patients (45%)), breast (4 patients (18%)), lungs (4 patients (18%)), uterus (2 patients (10%)), colon (1 patient (4,5%)), and stomach (1 patient (4,5%)). Clinical presentation in debut of PNM included skin erythema (8 patients (81%)), ulcer vasculitis (3 patients (13,6%)), muscle syndrome (3 patients (13,6%)), and fever (1 patient (4,5%)). Dysphagia was determined in 19 patients (86,4%). MMT in patients with PNM before and the year after steroid therapy was similar to the patients with DM/PM. All patients with PNM were Jo-1 antibodies and interstitial lung disease negative. CK level in patients with PNM was lower to compare with patients with DM/PM (1893±1846 vs 3704±3916, p≤0,027); opposite, ESR level in patients with PNM was higher to compare with patients with DM/PM (31,65±15,16 vs 17,35+10,9, p≤0,0001). Levels of CK and ESR were the same after 12 months of steroid therapy. During the period of investigation 9 patients died, 9 patients survived. 4 patients had 5 years survival rate. The fate of 4 patients is unknown. 16 (72,7%) patients had skin erythema and 2 (9,09%) patients had ulcer vasculitis in period of normalized muscle power. The aggravation of PNM in 50% of patients was related to metastasis. <h3>Conclusions</h3> PNM occurs in 9,9% patients with DM/PM. Most of the patients are older 50 years. PNM has clinical features of DM. The main features are Jo-1 antibodies and interstitial lung disease negative, the high level of dysphagia, increasing of muscle power during steroid therapy, and not sufficient effect of steroid concerning skin syndrome. <h3>Disclosure of Interest</h3> None declared <h3>DOI</h3> 10.1136/annrheumdis-2014-eular.3641
Abstract 3028: Peroxisome proliferator-activated receptor ≤ (PPARδ) reveals a critical role in promoting the TGFβ-induced EMT and metastasis of non-small cell lung cancer cell (H460)
Authors: Li-Chiung Lin, Shih-Lan Hsu, Chieh-Liang Wu, Chi-Mei Hsueh
Journal: Cancer Research (2012)

Abstract Although transforming growth factor ≤ (TGFβ) is anti-cancer identified, it was also known to promote tumor malignancy by enhancing the growth, epithelial to mesenchymal transition (EMT), tissue invasion and metastasis in a variety of cancer cells, including non-small cell lung cancers (NSCLCs). The aim of this study was to know the contribution of peroxisome proliferator-activated receptor ≤ (PPARδ) to TGFβ-promoted EMT and metastasis in NSCLCs. The degree of EMT, cell scattering, migration and invasion, and protein expression of PPARδ were first analyzed and compared between H460 and CH27 cells with or without TGFβ treatment (both are NSCLC cell lines). Chemical or shRNA blocking assay was also utilized to further confirm the importance of PPARδ in promoting TGFβ-induced tumor metastasis. Finally, signaling pathway(s) responsible for TGFβ/PPARδ-mediated metastasis was evaluated. The results demonstrated that TGFβ can effectively triggered the EMT, cell scattering, migration and invasion in H460 cell, but only a slight EMT was seen in TGFβ-treated CH27 cell. Meanwhile, PPARδ expression was induced by TGFβ in H460 cells but remained unchanged in CH27 cell. This indicated that PPARδ may involve in TGFβ-mediated metastasis. Co-treatment of TGFβ with GW9662 (a specific PPARδ inhibitor) significantly blocked TGFβ-promoted metastasis of H460 cell indicating the presence of PPARδ was indeed critical for TGFβ-attributed tumor metastasis. TGFβ appeared to act through P38 signaling pathway to trigger the expression of PPARδ and the subsequent activation of epidermal growth factor receptor (EGFR)/c-mesenchymal-epithelial transition factor (c-MET) signaling pathway and the reduction of E-cadherin that eventually led to the EMT and metastasis of H460 cell. Additionally, TGFβ also act through P38 to trigger the expression of β-catenin which could bind to and up-regulate the expression of PPARδ. Blocking of β-catenin activity, however, did not interfere with the metastasis indicating β-catenin may not play a direct role in promoting the metastasis of H460 cell. Nevertheless, we can not preclude the possibility that β-catenin may still act through PPARδ to regulate the metastasis of H460 cell, indirectly. In summary, TGFβ-induced EMT and metastasis in H460 cell was PPARδ-dependent and GW9662 revealed a therapeutical value in the control of NSCLCs (H460). Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3028. doi:1538-7445.AM2012-3028
Effect of Cortisone in Sarcoidosis
Authors: Maurice Sones, Harold L. Israel, Mary B. Dratman, Jesse H. Frank
Journal: New England Journal of Medicine (1951)

ALTHOUGH sarcoidosis is commonly considered a benign condition, it may occasionally be a serious illness, resulting in blindness, respiratory insufficiency or death. In a search for an effective therapeutic agent, many substances have been tried. Fowler's solution and x-ray therapy have been found ineffective.1 More recently, benefit has been reported from the use of calciferol (vitamin D2),2 nitrogen mustard,3 and urethane,4 but in our experience neither these agents nor antibiotics have given consistent results.Because it tends to involve many organs, sarcoidosis bears a clinical resemblance to certain of the disseminated collagen diseases. The hyperglobulinemia characteristic of sarcoidosis is also . . .
FRI0174 Pain assessment for subcutaneous injection of biologics in the treatment of rheumatoid arthritis
Authors: M. Sato, M. Takemura, R. Shinohe
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Biologics have dramatically changed the treatment of rheumatoid arthritis (RA). In recently years, several biologics have become available, and about half of these drugs are delivered by subcutaneous (s.c.) injections. However, the pain caused by s.c. injection may become a problem in some cases. <h3>Objectives</h3> We aimed to evaluate the severity of s.c. injection-related pain in patients receiving biologics via these injections. <h3>Methods</h3> The visual analogue scale (VAS) scale was used to assess the impact of the s.c. injection-related pain. The VAS is a 10-cm horizontal line with pain descriptors. Patients indicated the magnitude of injection-associated pain by allocating a score ranging from 0 (no pain) to 100 (most intolerable pain). Each patient gave assessments for a maximum of 4 types of s.c. injections. Etanercept (ETN), adalimumab (ADA), and golimumab (GOL) were the selectable drugs that the patients received at present and/or in the past, and s.c. of influenza vaccination (IV) was used as a control. <h3>Results</h3> A total of 123 RA patients (mean age, 59 years; range, 30-84 years) participated in this study. There were 104 women (84.6%). The number of patients who provided VAS scores for IV, ETN, ADA, and GOL injections was 123, 70, 60, and 17, respectively. The VAS scores (median, IQR) were as follows: IV, 26, 15-46; ETN, 41, 22.5-57; ADA, 59, 30-82.7; and GOL, 35, 27-41. After adjustment using the VAS ratio (each biologics/IV), the VAS ratio (median, IQR) for the selectable drugs were as follows: ETN/IV, 1.140, 0.736-2.189; ADA/IV, 1.627, 0.973-3.898; and GOL/IV, 0.949, 0.800-1.125. The VAS score of GOL was about the same as that of IV, and s.c. injections of GOL seemed to be the least painful (GOL vs. ADA, p = 0.0052 and ETN vs. ADA, p = 0.0060). However, most of the patients answered that the insertion of the biologic drugs, not the sting of the needle, caused the maximum discomfort. <h3>Conclusions</h3> Patient-orientated evaluations of pain caused by s.c. injections showed that injections of GOL caused less pain than those of the other biologics. Although evaluations of injection-associated pain differ with each patient, more comfortable s.c. injections are necessary to improve patient convenience and increase compliance with RA treatment. <h3>Disclosure of Interest</h3> None Declared
Bloc biopsy by tunneling method using endoscopic submucosal dissection for an upper gastrointestinal submucosal tumor
Authors: H. Kobara, H. Mori, S. Fujiwara, N. Nishiyama, M. Kobayashi, T. Masaki
Journal: Endoscopy (2012)

Minimally invasive local resection techniques such as hybrid natural orifice transluminal endoscopic surgery (NOTES) are becoming established in the treatment of upper gastrointestinal submucosal tumor (UGISMT), especially gastrointestinal stromal tumor (GIST) [1]. However, the tissue obtained from UGISMTs by techniques such as endoscopic ultrasound (EUS)-guided biopsy is occasionally insufficient to make a diagnosis [2]. Therefore, we devised a safe and reliable technique for bloc biopsy by a tunneling method [3] [4] using endoscopic submucosal dissection (ESD) [5]. Here, we describe the methodology of this technique.
P48 Vitamin D Levels Are Not Associated with Markers of Inflammation and Disease Severity in Acute Tuberculosis: Abstract P48 Table 1
Authors: FM Perrin, E Togun, S Stephens, O Sewo, RD Barker
Journal: Thorax (2012)

<h3>Background</h3> There is considerable evidence that patients with clinical tuberculosis in the UK have low levels of circulating Vitamin D<sup>1</sup>. It has been suggested that acquired Vitamin D deficiency impairs immune function and therefore allows patients to transform from latent to clinical tuberculosis. Sceptics have suggested that the low Vitamin D levels seen in clinical tuberculosis are a result of disease activity rather than a cause of it. We examined whether Vitamin D levels were associated with blood markers of inflammation and disease severity inpatients newly diagnosed with tuberculosis. <h3>Methods</h3> All patients diagnosed with tuberculosis at an inner London teaching hospital since 2000 were eligible for inclusion in the study although systematic measurement of Vitamin D levels has only been attempted in recent years. Vitamin D levels were classified as deficient &lt;=10ng/ml, insufficient&gt;10 to &lt;30ng/ml and sufficient &gt;=30ng/ml.2 The date treatment started was recorded. The first blood measurement of Vitamin D, Haemoglobin, Neutrophil count, c-reactive protein(CRP), erythrocyte sedimentation rate (ESR) and albumin taken within two weeks of treatment starting were recorded. All variables were assessed for correlation with one another using Pearson’s correlation coefficient in SPSS. <h3>Results</h3> One thousand four hundred and twenty two patients were identified of whom 262 had a measurement of Vitamin D. 151 (58%) were Vitamin D deficient and a further 96 (37%), Vitamin D insufficient. Data availability ranged from 1266 patients with a serum albumin to 222 patients with an ESR. Blood markers of disease severity and inflammation were significantly correlated but Vitamin D levels did not correlate with any of the other variables. <h3>Discussion</h3> These data do not support the hypothesis that low Vitamin Dlevels in acute tuberculosis are a result of disease activity or severity. It would be reasonable to consider the prevention of Vitamin D deficiency as a means to reduce the conversion of latent to clinical tuberculosis. <h3>References</h3> Sita-Lumsden A, Lapthorn G, Swaminathan R, Milburn HJ. Reactivation of tuberculosis and vitamin D deficiency: the contribution of diet and exposure to sunlight. <i>Thorax</i> 2007; 62(11):1003–7. Rosen CJ. Vitamin D Insufficiency. <i>New EnglandJournal of Medicine</i> 2011; 364(3):248–54.
Hypertensive crisis after endoscopic ultrasound-guided fine-needle aspiration of the right adrenal gland
Authors: Annemarie de Vries, Jan-Werner Poley
Journal: Endoscopy (2014)

A 51-year-old man was referred for endoscopic ultrasound (EUS)-guided fine needle aspiration (FNA) of a suspected adrenal metastasis of lung cancer. Computed tomography (CT) scans disclosed persistent pleural thickening of the right upper lobe after an episode of pneumonia, and an enlarged right adrenal gland ([Fig. 1]). At positron emission tomography CT (PET-CT) scan, both sites showed increased fluorodeoxyglucose (FDG) uptake. EUS with the patient under conscious sedation with midazolam and fentanyl demonstrated an enlarged, heterogeneous right adrenal gland of 50 mm diameter, with a hypoechogenic center ([Fig. 2]). Transduodenal FNA was performed twice with a 25-gauge needle (Echotip Ultra, Cook Endoscopy). During post-procedure monitoring for 2 h, only mild symptoms of nausea were observed and the patient was subsequently discharged.
MB-01 * NOTCH1 PROMOTES MYC MEDULLOBLASTOMA METASTASIS, INITIATION AND MAINTENANCE
Authors: S. Kahn, R. Nitta, K. Wang, S. Gholamin, T. Azad, M. Zhang, Y.-J. Cho, M. Taylor, S. Mitra, I. Weissman, S. Cheshier
Journal: Neuro-Oncology (2015)

Medulloblastoma (MB) is a malignant brain tumor that originates in the cerebellum in children and spreads via the cerebrospinal fluid to the leptomeningeal spaces of the brain and spinal cord. MB is stratified into four distinct groups, according to genetic and clinical features, and patients from group 3 (also known as c-Myc-amplified) have the highest risk of developing metastatic disease and, consequently, poor prognosis. Treatment protocols involve surgery, craniospinal radiation, and high-dose chemotherapy, which frequently cause disabling neurotoxic effects in long-term survivors. We used MB cell lines and primary cells isolated from patients from the c-Myc-amplified group as tools to understand the cellular determinants of leptomeningeal dissemination. Cells isolated from metastatic tumors express 10 times more NICD1 (Notch1 Intracellular Domain), the active form of Notch1, than cells isolated from primary sites (as quantified by western blot and imunohistochemistry), what implies the upregulation of Notch1 signaling pathway in MB metastasis. Moreover, flow cytometry analyses revealed that the cells isolated from metastatic sites express higher levels of full-length Notch1 when compared to cells from primary sites. These differences occur because of the enrichment in the cancer stem cell population at the metastatic sites, as we observed that MB cells isolated from metastatic tumors exhibit higher self-renewal potential than cells from primary tumor sites.
Abstract 3722: Ovarian suppression with gonadotropin-releasing hormone analogues (Gn-RH) in high risk premenopausal breast cancer patients (PM-HR-BC): decrease of T regulatory cells (T-regs) and of vascular endothelial growth factor (VEGF)
Authors: Francesco Recchia, Giampiero Candeloro, Stefano Necozione, Giovambattista Desideri, Maurizio S. D'Andrea, Cornelia O.C. Recchia, Silvio Rea
Journal: Cancer Research (2010)

Abstract Background: In a previous phase II study we have shown an improvement of disease-free survival and overall survival of 180 premenopauseal high-risk early breast cancer patients (PM-HR-BC) treated with ovarian suppression with Gn-RH and a chemotherapy tailored to the peculiar clinical situation. Aim of this study was the evaluation of VEGF and T-regs in a group of PM-HR-BC patients treated with the above mentioned therapy. Methods: From 01/2006 to 12/2008 54 patients with PM-HR-BC were entered into this study. At baseline, one week before chemotherapy, patients received a Gn-RH analogue which was continued for five years. Tailored adjuvant chemotherapy, included anthracycline and taxane based regimens. 11 patients with triple negative tumors, received a platinum-based consolidation high-dose chemotherapy with (n. 7) or without (n. 4) autologous peripheral blood progenitor cell transplantation, respectively. Radiation therapy was administered to all patients that had received breast conserving surgery. Patients received a strong psychological support, biphosphonates, and after the end of chemotherapy, estrogen receptor positive (ER+) patients received an aromatase inhibitor. Results: Characteristics of patients. Median age was 41 years (range, 26-44 yrs). 79% of patients were ER+, while 21% were estrogen receptor negative. Total number of positive nodes was 145, with a mean of 2,7 for each patient (range 0-25). G3 tumors were observed in 33% of patients, C-erB-2 status (FISH) was positive in 17% of patients, while mean Ki-67 value was 27%. Serum estradiol was suppressed to values &amp;lt; 40 pg/mL in all patients. After six months and one year, a statistically significant decrease was observed in T-regs number (p&amp;lt; 0.005) and VEGF (p&amp;lt; 0.005) with respect to baseline values. No impairement of cognitive function was observed with respect to baseline conditions. After a median follow-up of 26 months, 4 years progression-free survival and overall survival rate were 97% and 100%, respectively. Conclusions: These data show that ovarian suppression with a Gn-RH analogue decreases T-regs and VEGF, and seems to improve the expected outcome of PM-HR-BC patients through immunologic mechanisms. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3722.
SAT0332 Non-Tuberculous Septic Arthritis : a Study of 51 Cases
Authors: I. Cherif, H. Sahli, R. Tekaya, L. dridi, O. Saidane, I. mahmoud, L. abdelmoula, R. Zouari
Journal: Annals of the Rheumatic Diseases (2013)

<h3>Background</h3> Septic arthritis may cause damage and inflammation in short period of time and may also be a serious cause of mortality. Only early diagnosis and treatment can allow good prognosis. <h3>Objectives</h3> Our objective is to describe the cases of non tuberculosis septic arthritis, which were reported and confirmed in our hospital. <h3>Methods</h3> This a retrospective study which included medical records of patients treated for non tuberculosis septic arthritis during the ten past years [2002-2012]. Epidemiologic, clinical, biologic and therapeutic data were recorded and analysed. <h3>Results</h3> Fifty one cases of non tuberculosis septic arthritis were treated during the ten past years. The mean age was 52,8 years (range 22 to 90 years) with a female to male ration 1.1. The predisposing conditions were present in 50% of cases: diabetes mellitus (8 cases), renal failure (8 cases), rheumatoid arthritis (2 cases), psoriatic arthritis (1 case), osteoarthritis (3 cases) and hepatic cirrhosis (2 cases), high-dose corticosteroid intake (1 case) and arthroscopy (1 case). The median duration from the onset of symptoms to the diagnosis of septic arthritis was 20 days (1 range to 75days). Fever was observed in 97% of cases an average value of 38,3(37,9-40,5). Anorexia and weight loss were present in 7 cases. Mono-arthritis were noted in 43 cases (84%), localized in knees (24 cases), hips (6 cases), elbow (5 cases), Shoulders (3 cases), ankles (2 cases), sternocostal joint (1 case), manubriosternal joint (1 case) and sternoclavicular joint (1 case). Oligo-arthritis were noted in 4 cases and polyarthritis in 6 cases. Biological inflammatory tests were rised in all cases. Hyperleucocytosis was noted in 43% of cases and leucopenia in 3 cases. Radiographies schowed soft tissueabnormalities (8 cases), joint narrowing (17 cases) and joint destructions (7 cases). The germ has been identified in 52% (26 cases) of the cases and recovered in the joint in 17.6% of cases. <i>Staphylococcus was the most common (10 cases)</i>. The other germs were: Streptococcus (4 cases), Pseudomonas (2 cases), Gonococcus (1 case), E.Coli (6 cases), Proteus mirabilis (2 cases) and a combination of two microorganisms in one case. The treatment associated parental use of two antibiotics for 6 weeks except for for gonococcal arthritis. Joint washing was indicated in all cases. Surgical treatment was performed in 5 cases. We noted a good outcome in most cases with only a flessum in 4 cases. Nevertheless, 3 patients with diabetes died. <h3>Conclusions</h3> Septic arthritis should be evocated in front of any arthritis, especially if it is acute, with fever and in presence of predisposing factors. The predominant germ is the staphylococcus and the treatment must be urgent to avoid complications. <h3>Disclosure of Interest</h3> None Declared
ALTERED UMBILICAL ARTERIAL BLOOD FLOW IN THE 3RD TRIMESTER AND ITS ASSOCIATION WITH CLINICAL AND NEURODEVELOPMENTAL OUTCOMES IN CHILDREN WITH HYPOPLASTIC LEFT HEART SYNDROME
Authors: Dora Gyenes, Joseph Atallah, Charlene M.T. Roberston, Gwen Y. Alton, Winnie Savard, Irina Dinu, Fahimeh Moradi, Lisa Hornberger
Journal: Journal of the American College of Cardiology (2016)
ASSESSMENT OF LEFT VENTRICULAR FUNCTION AFTER PERCUTANEOUS CORONARY INTERVENTION OF CHRONIC TOTAL OCCLUDED CORONARY ARTERY BY SPECKLE TRACKING AND CARDIAC MAGNETIC RESONANCE
Authors: Elena Rodríguez González, Susana Mingo, Vanesa Belen Monivas Palomero, Jesús González Mirelis, Josebe Goirigolzarri Artaza, Blanca Zorita Gil, Jose Antonio Fernandez Diaz, María Alejandra Restrepo Córdoba, Jorge Vázquez López-Ibor, Javier Goicolea Ruigomez
Journal: Journal of the American College of Cardiology (2016)